bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of pathogenic CFTR gene variants in CF patients with negative neonatal screening
Authors: Петрова Н.В. , Каширская Н.Ю. , Кондратьева Е.И. , Шерман В.Д. , Воронкова А.Ю. , Васильева Т.А. , Зинченко Р.А.
Published: November 2020

Особенностями спектра патогенных вариантов гена CFTR у пациентов с отрицательным результатом по неонатальному скринингу на муковисцидоз по сравнению с пациентами с положительным результатом являются более высокая доля генотипов, ассоциированных с остаточной функцией поджелудочной железы, более высокая частота варианта 3849+10kbC>T и более низкая доля гомозигот по варианту F508del.

Features of the spectrum of pathogenic CFTR gene variants in CF patients with negative neonatal screening compared to positive screening CF patients include a significantly higher frequency of genotypes associated with residual pancreatic function, a higher frequency of 3849+10kbC>T, and a lower frequency of F508del variant homozygotes.
Diagnosis of milder forms of phenylketonuria in the population of the Sverdlovsk region
Authors: Дерябина С.С. , Лагутина О.В. , Беляева Т.И. , Никитина Н.В. , Подолина В.К. , Николаева Е.Н.
Published: November 2020

В работе представлены результаты расширенного генетического исследования 39 детей, наблюдавшихся в КДЦ «Охрана здоровья матери и ребенка» (г. Екатеринбург) с диагнозом «гиперфенилаланинемия». Анализ результатов обследования детей (у 13-ти пробандов наличие варианта R408W в гетерозиготном состоянии) показал, что поиск рекуррентных вариантов гена с использованием панели для ДНК-диагностики не дает ожидаемой верификации диагноза и требует дополнительного тестирования. Прямое секвенирование гена PAH позволило подтвердить диагноз «фенилкетонурия» (ФКУ) у 35 пробандов (89,8%) - у них обнаружено по 2 измененных аллеля. Еще у 4-х пациентов обнаружен только один патогенный вариант. Исследование ДНК родителей и сибсов указало на семейный вариант наследования всех выявленных мутаций. В результате проведенного исследования спектр патологии гена PAH, характерный для популяции Свердловской области, претерпел существенные изменения, что требует нового подхода к генодиагностике данной наследственной патологии в регионе.

The paper presents the results of an extended genetic study of 39 children observed in the MC “Health Care of Mother and Child” (Ekaterinburg) with a «hyperphenylalaninemia». An analysis of the previously known results of the study in these patients (the p. R408W variant in the heterozygous in 13 probands) showed that the search for recurrent gene variants using the panel does not give the expected proving of the diagnosis and requires additional testing. Applying the «gold standard» of diagnosis - direct sequencing of the PAH gene, the diagnosis of phenylketonuria (PKU) was confirmed in 35 probands (89.8%) - 2 altered alleles were found in them, one pathogenic variant was found in 4 others. A study of the DNA of parents and siblings indicated a families’ variants of inheritance for all identified mutations. As a result of the study, the pathology spectrum of the PAH gene, currently in use for the population of the Sverdlovsk region, has undergone significant changes, which require a new approach to the genetic diagnosis of this hereditary pathology in the region.
Molecular genetic characteristics of phenylketonuria in the population of Kazakhstan
Authors: Салимбаева Д.Н.
Published: November 2020

Целью исследования было изучение спектра и выявление этнических особенностей мутаций гена РАН у пациентов с ФКУ в Казахстане. В статье представлены результаты молекулярно-генетического обследования 88 пациентов с ФКУ из неродственных семей, из них 36 пациентов казахской национальности, 44 русских, 5 уйгуров и 3 узбека. Наиболее частой мутацией в гене РАН у казахов была мутация p.243Q (с частотой 0,250), у русских, уйгур и узбеков - мутация p.R408W с частотой 0,545, 0,400 и 0,333 соответственно. Только у казахов были выявлены следующие мутации в гене РАН: IVS4+5G>T, IVS10-14C>G (0,028), p.V230I (0,028), p.A300S (0,014), p.W187X (0,014), p.R158Q (0,014), p.Y387H (0,014), p.I65N (0,014), p.R243L (0,014), p.Val399= (0,014), c.326e>G (0,014), p.P119S (0,014). Мутации IVS7-3C>A и p.E390G гена РАН были обнаружены только у русских. Для пациентов уйгурской национальности этнически специфичной оказалась мутация p.R413P, для узбеков - мутации p.R261X, G188D, p.R252Q, c.826-829 ins/del4?. Полученные результаты позволили описать спектр и этнические особенности мутаций гена РАН в Казахстане.

The aim of the study was to study the spectrum and identify ethnic characteristics of mutations of PAH gene in patients with PKU in Kazakhstan. The article presents the results of molecular genetic examination of 88 patients with PKU from unrelated families, including 36 patients of Kazakh nationality, 44 Russians, 5 Uighurs and 3 Uzbeks. The most frequent mutation in the PAH gene in Kazakhs was p.243Q mutation (with a frequency of 0.250), in Russians, Uighurs and Uzbeks p.R408W mutation with a frequency of 0.545, 0.400 and 0.333, respectively. Only in Kazakhs, following mutations were identified in PAH gene: IVS4 + 5G> T, IVS10-14C> G (0.028), p.V230I (0.028), p.A300S (0.014), p.W187X (0.014), p.R158Q (0.014), p.Y387H (0.014), p.I65N (0.014), p.R243L (0.014), p.Val399 = (0.014), c.326e> G (0.014), p.P119S (0.014). Mutations IVS7-3C> A and p.E390G in PAH gene were found only in Russians. For patients of Uyghur nationality, mutation p.R413P turned out to be ethnically specific; for Uzbeks, the mutations p.R261X, G188D, p.R252Q, c.826-829 ins/del4?. The results obtained allowed us to describe the spectrum and ethnic characteristics of mutations of PAH gene in Kazakhstan.
Pharmacological chaperones glucocerebrosidase as treatment of Gaucher disease
Authors: Копытова А.Э. , Николаев М.А. , Богданова Д.А. , Сенкевич К.А. , Байдакова Г.В. , Большакова О.И. , Саранцева С.В. , Рычков Г.Н. , Чеблоков А.А. , Ибатуллин Ф.М. , Милюхина И.В. , Захарова Е.Ю. , Пчелина С.Н. , Емельянов А.К.
Published: November 2020

Мутации в гене лизосомного фермента глюкоцереброзидазы (GBA), приводящие к дисфункции фермента глюкоцереброзидазы (GCase), в гомозиготном состоянии вызывают болезнь Гоше (БГ), а в гетерозиготном состоянии повышают риск развития болезни Паркинсона (БП). Обсуждается использование фармакологических шаперонов (ФШ) GСase для терапии как БГ, так и GBA-ассоциированной БП (GBA-БП). Используя ФШ амброксол мы показали увеличение ферментативной активности GCase и снижение концентрации лизосфинголипидов HexSph в культуре первичных макрофагов пациентов с БГ и GBA-БП. Впервые проведена оценка эффективности новых химических соединений, модификаций ранее описанного аллостерического ФШ.

Gaucher disease (GD), caused by GBA mutations, encodes lysosomal enzyme glucocerebrosidase (GCase). Pharmacological chaperones could potentially enhance GCase activity and treat GD and PD linked to mutations in the GBA gene (GBA-PD). Using ABX as pharmacological chaperone for macrophages derived from GD and GBA-PD patients we observed significantly enhanced GCase activity and decrease of HexSph concentration. For the first time was evaluated the effectiveness of chemical modifications of the previously described allosteric pharmacological chaperone.
It’s like gossip. Problems and ethical challenges in sociological qualitative research on relations between adult siblings
Authors: Dębska Katarzyna
Published: November 2020

In research on family relations (between mothers and daughters, intimate partners etc.) various research methods are used (individual interviews with family members, dyads, focused group interviews, ethnographic observation) in order to learn the variety of perspectives and experiences of family members. Such an approach enables a researcher to analyze the problem in a more multidimensional way in comparison with a situation when the research is conducted only with one of the family members. However, engaging more research participants, who are often tied to each other with complicated emotional bonds, creates various ethical and methodological challenges. Considering this issue, I refer to my experience in conducting research on the dynamics and forms of adult siblings’ relations through their life course. I conducted interviews with 41 women and 14 men (in 7 cases more than one sibling from a family took part in my research). In the rest of the cases my interviewees rejected the possibility of my contacting their siblings. In this article I discuss issues concerning the recruitment of research participants belonging to the same family, managing data confidentiality when individuals who know each other are interviewed, and the dynamics of power relations between the researcher and the research participants.
Sculpin Cottus cf. poecilopus Heckel, 1837 in Baikal Lake Basin: First Findings
Authors:   Irkutsk State University, Andreev R. S. , Matveev A. N. ,   Irkutsk State University, Samusenok V. P. ,   Irkutsk State University, Yuriev A. L. ,   Irkutsk State University, Vokin A. I. ,   Irkutsk State University, Samusenok I. V. ,   Irkutsk State University, Alekseyev S. S. ,   Koltzov Institute of Developmental Biology RAS,   A.N. Severtsov Institute of Ecology and Evolution RAS
Published: November 2020

For the first time for the Baikal Lake basin, evidence of the existence of populations of sculpin Cottus cf. poecilopus Heckel (alpine bullhead) characteristic of the adjacent Lena River basin in large northern Baikal tributaries, the Verkhnaya (Upper) Angara and the Kichera is provided. In June 2009 during the study of the lower reaches of the Kholodnaya River (Kichera-Baikal system), 8 individuals of sculpin aged from 3 to 5 years and in August 2009 5 more specimens aged from 4 to 6 were caught. All fish were fertile with the gonads in maturity stage III. In August 2010 33 individuals aged from 4 to 6 were collected in the main channel of the Upper Angara near Novy Uoyan settl.. At about the same time C.poecilopus was registered in stomachs of Arctic charr from Lake Amut (Churo-Upper Angara-Baikal system) near the divide with the Pravaya (Right) Mama (Mama-Vitim-Lena system). In August 2010 17 specimens aged from 1 to 4 were caught in the Upper Angara near the mouth of its large left tributary the Yanchui River. Sculpins from the rivers Kholodnaya, Upper Angara and Yanchui have higher growth rate as compared to the ones from mountain lakes of the upper Lena basin. About 90 % of males and females matured at the age of 3 years. Absolute fecundity of two females from the Upper Angara River was 149 and 556 (with a mean of 352,5) eggs and of two females from the Kholodnaya River, 223 and 305 (with a mean of 264) eggs. This exceeds the fecundity of sculpins from mountain lakes in the Lena part of Baikal rift zone, which averages less than 150 eggs. Sculpins spawn in the Kholodnaya River in the 1st half of June. The diet of C. cf. poecilopus all over the Baikal basin as well as in adjacent sites in the Lena basin was basically composed of larvae of amphibious insects (trichopterans, ephemeropterans, chironomids and plecopterans). The discovery of the third species from the Lena basin in the Baikal basin following the findings of Arctic charr Salvelinus alpinus and grayling Thymallus baicalolenensis evidences the absence of differences in the structure of ichthyofaunas of the upper parts of both neighboring basins. Sculpins permeate along the streams to mountain lakes more easily than other species and colonize the most elevated ones in lake cascades within the northern part of Baikal rift zone. Their dispersal across the divide could proceed in two ways: via headwater captures or via flattened passes between converging upper reaches of adjacent streams.
小瞳孔超声乳化白内障摘除23例临床分析
Authors: 程 世明 , 陈 明洪
Published: November 2020

目的：探讨小瞳孔白内障超声乳化手术的操作经验及疗效。方法：23例23只眼小瞳孔白内障3~4级核病人纳入观察，其中男性13例，女性10例；年龄53~78岁；全部患者瞳孔都小于4mm且药物不能散大，有5例虹膜后粘连；一律采用爱尔康laureate型超乳机（蠕动泵）超声乳化摘除，术中灵活掌控流量、负压和能量参数，并借助辅助器械和粘弹剂完成每一个关键动作；术后随访1~3个月，观察视力、瞳孔、眼压、眼底、人工晶体位置等情况，以末次随访为疗效判定时间点。结果：手术后视力达0.6以上者16只眼，0.4~0.5者5只眼，0.2和0.1各1只眼；眼压低于10mmhg者1只眼，后发障1只眼，黄斑囊样水肿1只眼；囊袋内人工晶体脱入睫状沟1只眼。结论：只要术者在术中充分运用自己的临床经验，谨慎操作，在辅助器械及粘弹剂的帮助下，小瞳孔白内障超乳手术一样能获得成功。
腹腔镜辅助改良Swenson术式治疗小儿先天性巨结肠效果
Authors: 肖 志华 , 梁 坤兰 , 岑 君 , 黎 兆攀 , 潘 日芳 , 吴 海英
Published: November 2020

目的：探讨腹腔镜辅助改良Swenson术式在常见型小儿先天性巨结肠中治疗效果及价值。方法：选取接受腹腔镜辅助改良Swenson术式或腹腔镜辅助Soave术式的103例常见型先天性巨结肠患儿，根据手术方式分为Swenson组（63例）、Soave组（40例）。比较两组手术指标、术后短期恢复情况、并发症发生情况。随访1年以上，观察患儿生活质量评分、肛门功能评分、远期并发症发生率。结果：两组在术后留置尿管时间、术后进食时间差异无统计学意义（P＞0.05），Swenson组术中出血量低于Soave组，手术时间短于Soave组，术后排便频率低于Soave组，术后肠蠕动恢复时间、术后住院时间短于Soave组，差异有统计学意义（P＜0.05）。两组术后短期内吻合口瘘、盆腔感染、尿潴留发生率差异无统计学意义（P＞0.05），而Swenson组术后便秘、小肠结肠炎、粪污、吻合口狭窄、肛周皮炎发生率低于Soave组，差异有统计学意义（P＜0.05）。随访1年以上，两组术后便秘、小肠结肠炎、粪污、吻合口狭窄、肛周皮炎发生率差异无统计学意义（P＞0.05）。随访1年以上，两组生活质量及肛门功能优良率均较高，组内差异无统计学意义（P＞0.05）。结论：在常见型小儿先天性巨结肠治疗中，腹腔镜辅助改良Swenson术式与Soave术式相比，在术中出血方面及术后恢复、短期内术后并发症发生率等方面更具优势
中国新疆尖果沙枣果实中总生物碱和总皂苷的含量测定及其分析
Authors: 开赛尔 买买提明特肯 , 古丽仙 阿布萨迪尔 , 玛依拜尔 艾则孜
Published: November 2020

目的：通过乙醇提取法分析和定量研究采用乙醇提取法对尖果沙枣的总皂苷的含量。方法：采用75％乙醇和95％乙醇回流加热-超声提取法提取沙枣果实中的生物碱和皂苷，测定其含量。结果：75％乙醇对生物碱和皂苷的提取率较高。当用75％乙醇提取物测定生物碱和皂苷时，生物碱和皂苷的含量分别为5.173（mg/100ml）和2.163。结论：生物碱和皂苷的提取率随乙醇浓度的增加而降低。当进行抗氧化时，样品的浓度和取样量是重要的。最佳生物碱和总皂苷提取溶剂为75％乙醇。
临床中创伤后脑缺血的相关治疗方法及进展
Authors: 陈 磊 , 高 永军
Published: November 2020

创伤后脑缺血是神经外科临床工作中常见的一种伴发性疾病，其极可能带来致残、致死等严重后果，及时有效治疗抑制脑缺血性损害是临床工作的一项重要内容。近年来，随着科学的进步，创伤后脑缺血的治疗效果已有极大进步，论文针对其临床中的诊断和治疗方法及相关研究进展进行综述。
单纯前后位透视下经皮穿刺椎体成形术的临床应用
Authors: 崔 智慧
Published: November 2020

目的：探讨单纯前后位透视下经皮穿刺椎体成形术的可行性与安全性。方法：选取2011年9月-2015年9月在我院接受经皮穿刺椎体成形术的胸腰椎单节段骨质疏松性压缩性骨折患者100例，其中采用单纯前后位透视下经皮穿刺椎体成形术的患者 50例（观察组），采用正、侧位透视下经皮穿刺椎体成形术的患者50 例（对照组）。术前在CT 横断面影像上测量患者 T11~L2 椎体的左侧椎弓根长度，作为穿刺深度的参考。比较两组患者手术的穿刺时间和穿刺过程中的射线暴露时间、放射线暴露剂量，术后常规拍摄正侧位X线片以明确骨水泥注入的准确性。结果：100例患者均成功接受手术，无与穿刺相关的神经、血管等并发症，观察组患者穿刺时间和射线暴露时间、放射线暴露剂量均少于对照组，差异具有统计学意义（P＜0.05）。结论：单纯前后位透视下经皮穿刺椎体成形术安全、操作简单、射线辐射量少，是一种值得推广的穿刺方法。
离心力、离心时间对凝血四项检测结果的影响
Authors: 柳 金明 , 马 金珠 , 李 杰 , 田 静 , 杨 健 , 黄 黎会
Published: November 2020

目的：分析在2300g、1500g相对离心力（RCF）下得到的血浆用于检测活化部分凝血酶时间（APTT）、凝血酶原时间（PT）、血浆凝血酶时间（TT）和血浆纤维蛋白原（FIB）含量时检测结果是否有统计学意义，用以缩短实验室检测凝血四项时的离心时间。方法：随机抽取2020年1月-2020年2月我院门诊、住院患者及健康体检者凝血标本50例，将每例标本分成两份，其中一份以1500gRCF离心15分钟作为对照组，另一份以2300gRCF离心5分钟作为实验组。离心后分别检测每份血浆中的血小板浓度及APTT、PT、TT和FIB结果，分析检测结果。结果：此两种离心方法得到的血小板浓度均低于10×109/L，实验组和对照组的PT、APTT、TT和FIB的检测结果比较，差异无统计学意义（P＞0.05）。结论：测凝血四项时标本可采用2300g的RCF离心5min后进行检测。
Conflitos entre criadores da raça Moxotó e animais silvestres no Semiárido pernambucano
Authors: De Medeiros Rosália Barros Nascimento , Arandas Janaina Kelli Gomes , Alves Ângelo Giuseppe Chaves , Alves Rômulo Romeu Nóbrega , Ribeiro Maria Norma
Published: November 2020

Este artigo tem como objetivos identificar conflitos existentes entre criadores de caprinos da raça Moxotó e os predadores naturais dos seus animais, no município de Ibimirim, Pernambuco, bem como descrever as formas locais de prevenção aos ataques e suas implicações para conservação de raças caprinas e espécies silvestres. As informações foram obtidas através de entrevistas com questionários semiestruturados, complementadas com listas-livres. Foram entrevistados nove criadores, considerados especialistas locais. Foram identificadas 13 espécies selvagens como as principais causadoras de danos para as criações de caprinos da região. As espécies citadas foram carcará (Caracara plancus), gato-mourisco (Puma yagouaroundi), conhecido e designado na região pelos criadores como gato-do-mato azul e vermelho, jiboia (Boa constrictor), urubu (Coragyps atratus), cão doméstico (Canis familiaris), raposa (Cerdocyon thous), cascavel (Crotalus durissus), morcego (Desmodus rotundus), jararaca (Bothropoides erythromelas), onça-parda (Puma concolor) e gavião (espécie não-identificada), em ordem decrescente de importância.  O conflito entre criadores de caprinos e os animais silvestres se deve aos prejuízos econômicos causados pelos ataques. Os criadores diferenciam as espécies predadoras principalmente pela forma e intensidade dos ataques. Em geral, a caça ainda é a principal forma de prevenção dos ataques, porém, registraram-se formas locais de defesa para algumas espécies. É necessário que se estabeleça um diálogo constante entre os criadores e os órgãos ambientais responsáveis pelas políticas públicas com o objetivo de desenvolver estratégias para a conservação das raças locais, como a raça Moxotó, e espécies silvestres.
Ocorrência de Listeria spp. em salame tipo Italiano comercializados em supermercados do bairro de Casa Amarela, Recife-PE
Authors: Pessoa Camila Araújo Sousa de Sá , Aragão Breno Bezerra , Costa Caio Alves da , Santos Haliny Cristina Silva , Silva Maria Goretti Varejão da , Moura Andrea Paiva Botelho Lapenda de
Published: November 2020

Atualmente, os alimentos prontos para consumo têm se popularizado. Isto se deve ao fato da conveniência e propriedades nutricionais encontradas nesses produtos. Embora sofram processamento tecnológico na fabricação, falhas higiênico-sanitárias podem se tornar um sério risco à saúde do consumidor devido à veiculação de patógenos. Dentre estes, destaca-se o gênero Listeria que tem importância para a indústria de alimentos e saúde pública. Assim, objetivou-se neste estudo a detecção de Listeria spp. em salames tipo Italiano fatiados, embalados a vácuo e comercializados em supermercados do bairro de Casa Amarela, Recife-PE. Foram coletadas 22 amostras de salames tipo Italiano fatiados, embalados a vácuo das três principais marcas brasileiras, estas foram analisadas de acordo com a metodologia da Instrução Normativa de nº62/2003 do Ministério da Agricultura Pecuária e Abastecimento.  Dentre as amostras estudadas foi detectada uma ocorrência de 13,64% (3/22), este dado revela possíveis falhas na elaboração do alimento estudado, além de evidenciar a presença de Listeria spp. em salames tipo Italiano fatiados e embalados a vácuo.
Ocorrência de Giardia spp. em praças públicas de municípios do sul do estado do Rio Grande do Sul, Brasil
Authors: Ferraz Alexsander , Evaristo Tainá Ança , Pires Bruna Dos Santos , Pinto Diego Moscarelli , Nizoli Leandro Quintana
Published: November 2020

O objetivo deste estudo foi avaliar a presença de cistos de Giardia spp. em fezes de cães coletadas em praças de seis municípios do sul do estado do Rio Grande do Sul, Brasil. Entre os meses de setembro de 2017 a março de 2018 foram coletadas 20 amostras mensais em cada município estudado, totalizando 120 amostras mensais e 840 no total. As fezes foram processadas pelo método de Faust (1938). Das amostras analisadas, 153/840 (18,2%) continham cistos deste parasito. O município que apresentou maior percentual de amostras positivas foi Cerrito, com um total de 22,9% (32/140). Os municípios de Pelotas, São Lourenço, Rio Grande, Cassino e Pedro Osório apresentaram 16,4%, 16,4%, 17,9%, 18,6% e 17,1%, respectivamente. Pelo fato de serem locais públicos e Giardia apresentar potencial zoonótico, é necessário adotar medidas que visem à diminuição da contaminação dos animais e consequentemente do ambiente, diminuindo a exposição a este protozoário.
Impactos do vírus Schmallenberg na produção de ruminantes: revisão de literatura
Authors: Denadai Daniela Scantamburlo , Mendes Luiz Claudio Nogueira
Published: November 2020

Objetivou-se reunir informações relevantes sobre o Schmallenberg, uma doença viral emergente no continente europeu, que foi identificada pela primeira vez na Alemanha. Abortos, malformações fetais e mortes perinatais também estão associados ao vírus, observando-se principalmente artrogripose e alterações no sistema nervoso central. A transmissão pode ocorrer através de um vetor Culicoides spp., do sêmen ou por via transplacentária. O diagnóstico é realizado através de transcrição reversa seguida de reação em cadeia da polimerase (RT-PCR) com kits comerciais disponíveis, ou através de exames sorológicos de imunofluorescência indireta e prova de virusneutralização. Como ainda não existe um tratamento eficaz, torna-se importante as medidas de prevenção e controle, atuando no combate de vetores ou na vacinação do rebanho. Devido à importância desta doença no cenário mundial, é relevante o incentivo em pesquisas neste tema, além de conscientização das pessoas envolvidas na produção de ruminantes no Brasil.
Damaging Similarities in Highly Skilled Signature Simulations - Their Detection and Authorship
Authors: C. Joshi Mahesh , Singh Mohinder , Joshi Trilochan
Published: November 2020

Questioned document examination is a highly specialized and challenging field of study, because of the variety and complexity of problems that are referred to document examiners. Detection and identification of practiced simulated forgeries is an area of forensic science which requires the professional skill, capability and acumen of an examiner, every time he (or she) is called upon to examine and report a case of this nature. This is because firstly, the practiced simulations bear a striking semblance to the copied model and usually contains the handwriting features of the writers, the real person as well as the forger, though in varying degrees.Secondly, the skilled forger rarely leaves his own imprint in the forgery he committed. Most authorities on the subject have advised that the identification of authorship, in such cases, may be considered as an exception rather than the rule. Besides discussing and reviewing the work done in this regard, the authors have also presented and illustrated an intricate case study where the authorship of simulated signatures could be associated with the known handwriting of the suspected forger
Succession of Dipteran Fly Maggots on Poisoned Pig Cadavers at Nnamdi Azikiwe University, Awka, Nigeria
Authors: C. Abajue Maduamaka , C. Ewuim Sylvanus , A. Uhuo Cosmas
Published: November 2020

Dipteran maggots found on a cadaver are used to estimate its time of death but the time may be incorrect if death occurred due to ingestion of poison. Decomposition of a zinc phosphide intoxicated and strangulated pigs (Sus scrofa Linn.) were evaluated in this study.
They were deposited in a forest during the rainy season and repeated during the dry season at Awka, Nigeria. Decomposition duration and stages of decay of the pig cadavers were recorded. Maggots found on the cadavers were collected, reared to adulthood and were identified. Similar maggot samples were assessed for residues of zinc and phosphorus with an Atomic Absorption Spectrophotometer.
Both pig cadavers completely decomposed within 10 and 14 days during the rainy and dry seasons, respectively. Appearance and emergence of three dipteran maggot families were observed on the cadavers in a successional pattern. Zinc and phosphorus residues were detected in the maggots from the poisoned cadavers while they were not detected in the maggots from the strangled cadavers.
The three dipteran maggot families are recommended as a valuable tool in forensic entomology for the estimation of elapsed time of a questionable death and the dipteran bodies would also be useful for toxicological analysis.
Construindo o círculo na Geometria do taxi: uma proposta de insubordinação criativa
Authors: Cavalcante Raimundo Nonato Barbosa , Oliveira Jobson de Queiroz
Published: November 2020

A geometria é um ramo da Matemática cujos conceitos trabalham as formas, tamanho e posição de figuras relacionadas aos espaços, apresentando tipos diferentes. Nesse ramo alguns conceitos diferenciam as características do objeto, como o círculo, dependendo de qual tipo de geometria pretende-se trabalhar. O objetivo desse estudo foi apresentar a forma do círculo na geometria do táxi, desenvolvida por Hermann Minkowski, também baseada no plano cartesiano, utilizando o sistema de coordenadas cartesianas, mas com características próprias. O conteúdo não fazia parte do currículo escolar, assim, o pesquisador utilizou da Insubordinação Criativa, na busca em romper paradigmas curriculares, e introduziu o conceito de geometria do táxi. Para conduzir essa exploração, foram utilizadas oficinas como metodologia de ensino onde mostrou-se, através de atividades contextualizadas, as diferenças entre a distância na geometria euclidiana e na geometria do táxi, concluindo com a obtenção da figura do círculo a partir da definição já conhecida. Através das atividades, foram apresentados tópicos relevantes desse estudo despertando o aluno à reflexão acerca de conteúdos matemáticos já estabelecidos como possibilidade a novas descobertas e melhor compreensão da realidade.
Pengembangan Perangkat Pembelajaran IPA Berbasis Guided Inquiry
Authors: Nur’aini Nur’aini , Danial Muhammad , Sugiarti Sugiarti
Published: November 2020

This study is development research, which aims at producing guided inquiry-based IPA (Natural Sciences) learning tools in energy and life system subject which is valid, practical, and effective, discovering the level of validity, practicality, and effectiveness of guided inquiry-based IPA learning tools in energy and life system subject developed. The development of learning tools employed Thiagarajan (Four-D) model which consists of four stages, namely defining, design, development, and dissemination. The test of learning tools was conducted to the students of grade VII.1 at SMPN 36 Makassar of academic year 2018/2019. Data collecting employed observation sheet and questionnaire. The data were then analyzed by using descriptive analysis technique. The products produce in this study are the lesson plan (RPP), student’s worksheet (LKPD), and student’s textbook (BAPD). The results of the validation on the learning tools developed, it is obtained the mean score based on the assessors which met the valid criteria and all of the components of learning tools are valued as reliable. The result of the field test on the practicality of learning tools developed shows that there is consistency between the result of experts’ perceptions and observers’, which is both gave high criteria or good. The learning tools are also effective to be applied because the result of the field test indicates that there is consistency between the result of experts’ perceptions and observers’. The result of experts perceptions gave the effectiveness result with high criteria or good. The result of observation on four indicators of effective criteria were all met.
Analisis Miskonsepsi Peserta Didik Menggunakan Certainty of Response Index (CRI) pada Materi Stoikiometri
Authors: Wiwiana Wiwiana , Hasri Hasri , Husain Halimah
Published: November 2020

Many students are misconception, so the researchers do research with the aims to analyze the level of understanding of the participants’ concept students and the factors causing students’ misconceptions on the subject matter stoichiometry. Data collection uses open-ended diagnostic tests with a scale CRI with 18 numbers and interviews. The results showed the percentage of understanding concepts of 21% with a low percentage category, understand the concept but not sure at 7%, with the low category, the percentage of misconceptions of 12% with low categories and percentage do not understand the concept of 61% with a high category. Factors that cause misconception include a) students; c) how to teach.
Project Based Learning Model in Teaching Deutsch FÅ±r Tourismus for Foreign Language Students
Authors: Anwar Muhammad , Yusri Yusri , Angreany Femmy , Syaputra Arlian Fachrul , Hasmawati Hasmawati
Published: November 2020

This study aims to determine the effectiveness of the application of PBL (Project Based Learning) learning models in Deutsch fÃ¼r Tourismus courses in foreign language majors. This research is an experimental study using one group design as an experimental group without involving the control group. Respondents in this study were 30 students who were programming the Deutsch fuer Tourismus course. Student speaking skills data were measured using assessment rubrics with intervals of 1 to 9. This assessment rubric was adapted from assessments in the IELTS test specifically in aspects of speaking skills. The intervention given was in the form of implementing the PBL model for 6 meetings, where each meeting was 2 hours long. Data analysis techniques used are descriptive statistics and inferential statistics. There are 4 types of advantages of the PBL model that are felt by students when implemented in the learning process namely 1) can trigger students to find and explore ideas or ideas that they want to express when speaking. 2) train students to work in groups to solve a problem. 3) This model produces products that are self-developed by students. 4) The PBL model requires students to read a lot, so that it can have a positive effect in increasing student reading interest.Â Keywords: Learning Model; Project Based Learning; Deutsch fÃ¼r Tourismus; Speaking Skills
Influences of Price, Promotion, and Service quality on Communitiesâ€™ Interest in Choosing Vocational High School
Authors: Kasmad Kasmad , Mustakim Masran , Sunarsi Denok
Published: November 2020

This study aims at investigating the influence of price, promotion, and service quality on the societiesâ€™ interest to register their children in the Vocational High School in South Tangerang. This study employed the explanatory research method by involving 96 respondents. Data were analyzed using statistical analysis methods including regression test, correlation test, determination test, and hypothesis test. The findings showed that price significantly influences the communitiesâ€™ interest (32,4%) and the hypothesis test got the significance level at 0.000 < 0.05. Promotion is significantly influential at 36.9% and the hypothesis test showed a score of 0.000 < 0.05. The quality of the service is simultaneously significantly influential on the interest in Vocational High School at 30.2 % and the hypothesis test shows the significance score of 0,000 < 0,05. This indicates that price, promotion, and service quality can trigger societiesâ€™ interest to register their children into the Vocational High School. Thus, these three components can be solutions to increase the number of students in Vocational High Schools.
ANALISIS SURVIVAL DALAM MEMODELKAN SISWA PUTUS SEKOLAH
Authors: Hidayat Rahmat , Hastuti Yuli
Published: November 2020

Salah satu kendala dalam meningkatkan kuantitas dan kualitas pendidikan di Indonesia adalah masih tingginya angka anak putus sekolah usia wajib belajar. Metode yang dapat digunakan untuk memodelkan data tersebut adalah Analisis Survival. Penelitian ini memodelkan data usia anak putus sekolah di Kota Palopo dengan menggunakan Bayesian Analisis Survival. Hasil penelitian menunjukkan bahwa, tingkat pendidikan orangtua yang rendah dan jumlah anggota rumah mengakibatkan tingginya resiko putus sekolah siswa di Kota Palopo.
UJI APLIKASI BERBAGAI TINGKAT DOSIS PUPUK ZA TERHADAP PRODUKTIVITAS DAN MUTU JAGUNG
Authors: Tabri Fahdiana , Aqil M. , Efendi Roy
Published: November 2020

This  study aims to see the effect of optimal dosage of ZA fertilizer on maize productivity and quality. The results showed that the treatment without urea, in the treatment of NPK 300 / kg + ZA 100 kg / ha fertilizer dosage will decrease the yield from 10.8 tons / ha to 9.1 tons / ha, and BC Ratio 2.34 to 2, 08. Further treatment without urea (NPK + Urea) has the highest production of NPK fertilizer 300 kg / ha + ZA 200 kg / ha with profit rate Rp. 20.435.000, - and B-C Ratio 2.21. Furthermore the addition of ZA fertilizer doses will actually reduce the production and B-C Ratio
INSTRUMEN TES POTENSI AKADEMIK VISUALISASI SPASIAL/LOGIKA GAMBAR MODEL TIMBUL SEBAGAI INOVASI TEPAT GUNA UNTUK DIFABEL NETRA
Authors: Fathurrohmah Arditya Galih , Ratnasari Devi
Published: November 2020

is to validate the quality of the new instrument for a blind candidate college student. The result of our research is a potential academic test instrument for geometry logical test which is printed by an emboss technic. This instrument arises to effectively improve the ability to understand the meaning of the problem by students with disabilities. This is evidenced by the percentage of right answer to the 100% disabled when performing the matter in a way that is palpably independent, with minimal companion intervention.
Pengaruh Biaya Promosi terhadap Profitabilitas pada PT. Simpatik Cabang Gowa
Authors: Ardin Ardin
Published: November 2020

The aims of the research are 1) To analyze the influence of cost promotion consisted of advertisement, sale promotion, Personal Sale and the publicity of the profitability of Simpatik in Gowa branch, and 2) To analyze the influence of the most dominant variable on the profitability of Simpatik in Gowa branch. The research was conducted by the same of population and sample taken from three years lately included thirty-six months by financing corporation data in Gowa branch. The method used was analyzes of classic method and doubled linear regression by using SPSS. 20.  The result research through simultaneous testing showed that advertisement, sale promotion, personal sale and publicity variable gave the positive and significant influenced toward the profitability. Testing by partial way, the promotion and sale personality variable created negative influence and gave return equivalent toward the corporation of sale of Simpatik in Gowa branch. Next, in partial way, advertisement variable showed the most dominant influence toward profitability on the three of the others independent variable.
Pendekatan Perspektif Weber terhadap Tindakan Rasionalisme Pembuatan Perahu Pinisi
Authors: Dwi Hastuti Diah Retno , Mardia Mardia , Nuryanti Dewi Marwati , Ali Muhammad Saleh , Demmalino Eymal B. , Rahmadanih Rahmadanih
Published: November 2020

Indonesia's maritime triumph from history to being written in a song lyric is not a question, especially its reliability in making Pinisi boats whose processes are full of local wisdom and cultural values reflected in everyday life. The research conducted in Bira Village, Bontobahari Sub-district, Bulukumba District in            May 2018 aims to examine the rationalism of making pinisi boats with Weber's perspective approach. The aim is to use qualitative methods with Weber's approach in the verstehen perspective. The findings show that the making of the Pinisi boat is still filled with mystical nuances of religion ranging from the determination of the day of manufacture to its launch in the sea even though the elements of modernization began to come in to streamline time and streamline costs as a form of rationality in acting, as in Weber's perspective, zwerk rational, werk rational, affectual action, and traditional actions
Pengaruh Penerapan Studi Kasus terhadap Pengetahuan Pelanggaran Kode Etik Profesi Bidang IT bagi Mahasiswa Otomasi Sistem Permesinan
Authors: Rahmawati Nur Asmi
Published: November 2020

This study was conducted to determine the effect of the application of case studies on knowledge of violations of the professional code of ethics in the IT field for students majoring in Mechanical Systems Automation. The research method used was an experiment with the design of "one shot case study". The study was conducted on students who program Professional Ethics courses majoring in Mechanical Systems Automation.  The results of this study indicate that the value of students after doing a case study has increased. This shows that the case study method in this learning is appropriate to use.
Kemandirian dan Motivasi Belajar Siswa Terhadap Prestasi Belajar Program Keahlian Akuntansi Di SMK Negeri 1 Sidenreng Rappang
Authors: Sahade Sahade
Published: November 2020

This study aims to determine the effect of independence and learning motivation on student achievement in accounting expertise program at SMK Negeri 1 Sidrap. The population in this study were 66th grade students of the Accounting Skills Program, amounting to 66 students. Data analysis used descriptive analysis, classic assumption test, instrument test and hypothesis test with non-parametric statistics. The results of this study indicate that learning independence and motivation influence student achievement with a significant level < 0.05. The coefficient of determination (R2) is 0.538 or 53.8 percent. This means that students who have high independence and motivation to learn in accounting subjects will be able to improve student learning achievement itself by 53.8 percent while the remaining 46.2 percent is influenced by other factors beyond observation in this study. The increase in student achievement is dominated by learning independence with a coefficient of determination of 0.471 or 47 percent
Strategi Pengembangan Sumber Daya Manusia Melalui Pendidikan dan Pelatihan pada Kantor Dinas Tenaga Kerja Kota Makassar
Authors: Nirwan Putri Anna
Published: November 2020

This study aims to determine the strategy of developing human resources through education and training at the Makassar City Manpower Office. Using a qualitative descriptive approach. The main instrument in this study is the researcher himself using a cellphone, and using a field note that is by recording data related to research found in the field. Data collection was carried out by using observation, interview, and documentation techniques. Analysis of the data used is data reduction, data presentation and conclusions. The results showed that the strategy of developing human resources through education and training at the Makassar City Manpower Office was in a fairly good category, seeing the focus in this study, namely: 1) determining needs has been determined quite well, 2) determining targets that are in in the good enough category, 3) the determination of the program content is in the good enough category, 4) the principles of learning get pretty good results, 5) the implementation of the program gets pretty good results, 6) identification of the benefits of getting pretty good results, and 7 ) the evaluation of program implementation got quite good results
The Implication of Sustainable Career Development Implementation (PKB) On Teachers’ Career Management in an Education Unit
Authors: Nurhayati Yuli , Permana Johar , Herawan Endang , Aedi Nur
Published: November 2020

This study aims to examine the implications of the implementation of the Pengembanagan Keprofesian Berkelanjutan (PKB) policy on teacher career management in junior high schools in Bandung.  The implication is seen in Penilaian Kinerja Guru  (PKG) planning where the teacher explores her career needs, in the implementation of PKB where the teacher tries her career strategy, and in the evaluation where the teacher reflects on PKB. Teacher career management appears in the aspects of planning, implementation, and evaluation of  PKB
Effect of Promotion and Price on Customers' Purchase Interests at PT Sumber Cipta Multiniaga, South Jakarta Branch
Authors: Juhaeri Juhaeri
Published: November 2020

This study aims to determine the effect of promotion and price on customer buying interest at PT. Sumber Cipta Multiniaga South Jakarta Branch. The method uses explanatory research and hypothesis testing with survey techniques, by distributing questionnaires using a saturated sampling technique of 100 respondents. The analytical tool used is descriptive and verification analysis or inverential with the test instruments and classical assumptions. The statistical analysis uses multiple regression tests, correlation coefficient values, coefficient of determination and hypothesis testing. The results of the study are promotion and a significant positive effect with a correlation of 0.576 and determination of 33.2%. Hypothesis testing obtained ρ value 0,000 <0.05. Price has a positive and significant effect on customer buying interest, with a correlation value of 0.645 and a determination of 41.6%. Hypothesis testing obtained ρ value 0,000 <0.05. Promotion and price simultaneously have a positive and significant effect on customer buying interest with a correlation value of 0.695 and a determination of 48.3% while the remaining 53.1% is influenced by other factors not examined. Hypothesis testing obtained ρ value 0,000 <0.05.This study aims to determine the effect of promotion and price on customer buying interest at PT. Sumber Cipta Multiniaga South Jakarta Branch. The method uses explanatory research and hypothesis testing with survey techniques, by distributing questionnaires using a saturated sampling technique of 100 respondents. The analytical tool used is descriptive and verification analysis or inverential with the test instruments and classical assumptions. The statistical analysis uses multiple regression tests, correlation coefficient values, coefficient of determination and hypothesis testing. The results of the study are promotion and a significant positive effect with a correlation of 0.576 and determination of 33.2%. Hypothesis testing obtained ρ value 0,000 <0.05. Price has a positive and significant effect on customer buying interest, with a correlation value of 0.645 and a determination of 41.6%. Hypothesis testing obtained ρ value 0,000 <0.05. Promotion and price simultaneously have a positive and significant effect on customer buying interest with a correlation value of 0.695 and a determination of 48.3% while the remaining 53.1% is influenced by other factors not examined. Hypothesis testing obtained ρ value 0,000 <0.05.
Implementation of the Supervision Function on Public Sector Employees (Study at PT. PLN's South Sulawesi, Southeast Sulawesi and West Sulawesi Regions)
Authors: Rivai Nur Ilmiah
Published: November 2020

Good supervision is needed at the Office of PT. PLN (Persero) in the South Sulawesi, Southeast Sulawesi and West Sulawesi Regions so that employees can work effectively and produce optimal work. The purpose of this study, is to analyze the supervisory function carried out at PT. PLN (Persero) South Sulawesi, Southeast Sulawesi and West Sulawesi Regions. This research method uses quantitative research with descriptive research type. Data collection techniques using questionnaires in the form of a checklist and using descriptive analysis techniques. The results of the study showed that the direct supervision conducted was quite good, while the direct supervision was quite good.
The Effect of Placement and Career Development on Employee Performance of PT. Mandiri Karya in Jakarta
Authors: Muslimat Ade
Published: November 2020

This study aims to determine the effect of career placement and development on employee performance at PT. Mandiri Karya in Jakarta. The method used is explanatory research with analytical techniques using statistical analysis with regression testing, correlation, determination and hypothesis testing. The results of this study the placement of a significant effect on employee performance by 41.6%, the hypothesis test obtained t count> t table or (8,133> 1,986). Career development has a significant effect on employee performance by 43.8%, the hypothesis test is obtained t count> t table or (8.508> 1.986). Career placement and development simultaneously have a significant effect on employee performance by 52.6%, the hypothesis test is obtained F count> F table or (51.106> 2,700).
Analisis Kemampuan Pemecahan Masalah Matematika Siswa Melalui Soal Kelas II SDN 1 Selabintana
Authors: Nuraulia Novi , Uswatun Din Azwar , Nurrochmah Andi
Published: November 2020

This study aims to describe the students' mathematical problem solving abilities and the factors that influence the mathematical problem solving abilities of students in grade II of SDN 1 Selabintana. This type of research uses qualitative methods with a descriptive approach. Data collection techniques in this study were through observation and in-depth interviews. The data source of this research was in the form of data from interviews with grade II teachers of SDN 1 Selabintana. The data analysis technique uses the Miles and Huberman analysis model which is done interactively and continuously until it is complete so that the data is saturated. The results of this study indicate that the ability to solve mathematical problems through Class II questions SDN 1 Selabintana include: Ability to understand questions, ability to plan problem solving, the ability to answer and solve problems, and the ability to check the results of answers. As well as the factors that influence the mathematical problem solving ability of students in grade II SDN 1 Selabintana include: Learning difficulties, concentration, motivation, critical thinking skills, learning enthusiasm, learning media, and professional educators.
Strategi Dalam Pembelajaran Bahasa Indonesia Di Sekolah Dasar Daerah Terpencil Nusa Tenggara Timur (NTT)
Authors: Wabang Rince Jalla , Adam Lenny Nofriyani
Published: November 2020

Bahasa is one of the important materials taught in Indonesian schools for the important roles in our daily lives. The aim of this study is to determine the effectiveness of learning in a remote island in Flores. The method used is qualitative descriptive with a naturalistic approach and case study. This research was conducted in several places in a remote area on the island of Flores, East Nusa Tenggara. The result shows that Bahasa language learning in the remote area of Flores island is not maximal enough. Primary school teachers are still applying the conventional learning techniques and they do not want to be role models for the teaching-learning process.
Penerapan Brain Gym Terhadap Hasil Belajar Peserta Didik Pada Mata Pelajaran IPS Kelas V SD
Authors: Damayanti Refi , Hosnan M , Jamaludin Ujang
Published: November 2020

This study aims to determine the application of the Brain Gym in improving student learning outcomes in social studies lessons in class V. The research was conducted at SDN Kebaharan 1, Serang City 2019/2020. This research method uses a quasi-experimental Nonequivalent Control Grop Design. The population studied was grade V SD students. The sample was taken by using the purposive sampling technique. This research uses to test and non-test instruments. The tests are in the form of a pretest and posttest. Based on pretest data processing, it was obtained that the average value of learning outcomes in social studies subjects in the control class was 40.71% in the experimental class of 32.20%. Thus the learning outcomes of students before being given treatment were not different. After being given the treatment and given the posttest, based on data processing, the average value of student learning outcomes in the control class was 72.90% and the experimental class was 80.46%. After being treated the experimental class learning outcomes were better than the control class. Based on the research results it can be concluded that the application of the Brain Gym can improve the social studies learning outcomes of students in class V SD.
Pengembangan Media Pembelajaran Pop Up Book Pada Pembelajaran IPS Di Kelas IV SD
Authors: Apriliani Elyta , Nurhasanah Ana , Hakim Zerri Rahman
Published: November 2020

In the learning process in the classroom, students often find it difficult to understand the material being taught because the use of learning media is not optimal. This study aims to develop pop-up book learning media and to determine the feasibility of the developed pop-up book learning media. The type of research used is Research and Development (R&D) with research and development procedures from Borg and Gall. The instrument used was a questionnaire sheet for expert validation and student responses. Based on the data analysis, the material expert's assessment was 95.6% in the "Very Good" category; the linguist's assessment of 87.5% is categorized as "Very Good"; the media expert's assessment of 94.3% is categorized as "Very Good" and the assessment of the response of students in class IV SD Negeri Secang by 99% is categorized as "Very Good". So that the pop-up book meets the criteria to be used as a learning medium.