bluuebunny/crossref_metadata_2025 huggingface dataset:
Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations
Authors: Schallschmidt Tanja , Lebek Sandra , Altenhofen Delsi , Damen Mareike , Schulte Yvonne , Knebel Birgit , Herwig Ralf , Rasche Axel , Stermann Torben , Kamitz Anne , Hallahan Nicole , Jähnert Markus , Vogel Heike , Schürmann Annette , Chadt Alexandra , Al-Hasani Hadi
Published: October 2018

To identify novel disease genes for type 2 diabetes (T2D) we generated two backcross populations of obese and diabetes-susceptible New Zealand Obese (NZO/HI) mice with the two lean mouse strains 129P2/OlaHsd and C3HeB/FeJ. Subsequent whole-genome linkage scans revealed 30 novel quantitative trait loci (QTL) for T2D-associated traits. The strongest association with blood glucose [12 cM, logarithm of the odds (LOD) 13.3] and plasma insulin (17 cM, LOD 4.8) was detected on proximal chromosome 7 (designated Nbg7p, NZO blood glucose on proximal chromosome 7) exclusively in the NZOxC3H crossbreeding, suggesting that the causal gene is contributed by the C3H genome. Introgression of the critical C3H fragment into the genetic NZO background by generating recombinant congenic strains and metabolic phenotyping validated the phenotype. For the detection of candidate genes in the critical region (30–46 Mb), we used a combined approach of haplotype and gene expression analysis to search for C3H-specific gene variants in the pancreatic islets, which appeared to be the most likely target tissue for the QTL. Two genes, Atp4a and Pop4, fulfilled the criteria from our candidate gene approaches. The knockdown of both genes in MIN6 cells led to decreased glucose-stimulated insulin secretion, indicating a regulatory role of both genes in insulin secretion, thereby possibly contributing to the phenotype linked to Nbg7p. In conclusion, our combined- and comparative-cross analysis approach has successfully led to the identification of two novel diabetes susceptibility candidate genes, and thus has been proven to be a valuable tool for the discovery of novel disease genes.
Performing Parentage Analysis in the Presence of Inbreeding and Null Alleles
Authors: Huang Kang , Mi Rui , Dunn Derek W , Wang Tongcheng , Li Baoguo
Published: October 2018

Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a population, and/or nonrandom mating, usually leads to a genetic structure and results in genotypic frequencies deviating from those expected under the Hardy-Weinberg equilibrium (HWE). In addition, in the presence of null alleles, an observed genotype represents one of several possible true genotypes. The true father of a given offspring may thus be erroneously excluded in parentage analyses, or may have a low or negative LOD score. Here, we present a new mathematical model to estimate parentage that includes simultaneously the effects of inbreeding, null alleles, and negative amplification. The influences of these three factors on previous model are evaluated by Monte-Carlo simulations and empirical data, and the performance of our new model is compared under controlled conditions. We found that, for both simulated and empirical data, our new model outperformed other methods in many situations. We make available our methods in a new, free software package entitled parentage. This can be downloaded via http://github.com/huangkang1987/parentage.
Neurodevelopmental Consequences of Preterm Isolated Cerebellar Hemorrhage: A Systematic Review
Authors: Hortensius Lisa M. , Dijkshoorn Aicha B.C. , Ecury-Goossen Ginette M. , Steggerda Sylke J. , Hoebeek Freek E. , Benders Manon J.N.L. , Dudink Jeroen
Published: October 2018

CONTEXT:

The effect of neonatal cerebellar hemorrhage on neurodevelopmental outcome (NDO) in the absence of supratentorial injury is still largely unknown.

OBJECTIVE:

To evaluate the influence of isolated neonatal cerebellar hemorrhage on cognitive, motor, language, and behavioral NDOs and assess the effect of location and size on outcome.

DATA SOURCES:

Embase, Medline, and Scopus were searched from inception to September 30, 2017.

STUDY SELECTION:

Studies in which a diagnosis of isolated cerebellar hemorrhage was reported in preterm infants (<32 weeks’ gestation) with a standardized NDO at ≥12 months of age were included.

DATA EXTRACTION:

Patient characteristics, location, and size of bleeding and NDO (defined as severe [yes or no] on the basis of given cutoff points) in 4 domains were extracted.

RESULTS:

Of the 1519 studies identified, 8 were included in final analyses. Of infants with isolated cerebellar hemorrhage, 128 were described (cumulative incidence: 2.3%). The incidence of severe delay in cognition, motor, language, and behavioral development was 38%, 39%, 41%, and 38%, respectively. The overall incidence of severe neurodevelopmental delay in ≥1 domain ranged from 43% to 75% and was most seen in infants with vermis involvement (87%–93%) and with large bleeds (46%–82%).

LIMITATIONS:

Different neurodevelopmental scales lead to data heterogeneity, and reporting of data on a group level limited possibilities for an outcome description on an individual level.

CONCLUSIONS:

Of infants with isolated cerebellar hemorrhage, 43% to 75% were severely delayed in cognition, motor, language, and/or behavioral development, with the highest incidence with vermis involvement and with large bleeds.
A contrastive overlook at Asian literature in the Americas: two examples
Authors: Suárez José I.
Published: October 2018

This paper will critically explore and compare East Asian perspectives and adaptation modes in the Americas as well as self-perception within the realm of “the Other” through two novels: Yawara! A Travessia Nihondin-Brasil (Yawara! The Nihondin-Brazil Journey 2006) by Júlio Miyazawa, a Nipo-Brazilian (Nisei), and Yellow on the Outside, Shame on the Inside: Asian Culture Revealed by the Sino-American Anson Chi (Web published). ***Um olhar contrastivo sobre a literatura asiática nas Américas: dois exemplos***O presente artigo explora e compara criticamente as perspectivas do Leste Asiático e seus modos de adaptação nas Américas, bem como a autopercepção no âmbito do “Outro” em dois romances: Yawara! A travessia Nihondin-Brasil (2006), de Júlio Miyazawa, um nipo-brasileiro (nissei), e Yellow on the Outside, Shame on the Inside: Asian Culture Revealed (Amarelo por fora, vergonha por dentro: cultura asiática revelada), do sino-americano Anson Chi (publicado na Web).Palavras-chave: Nissei; Emigração; Outro; Cultura asiática.
Memory and the written testimony: the actresses of the public theatre in Calcutta in the 19th & 20th century
Authors: Gooptu Sarvani
Published: October 2018

Modern theatrical performances in Bengali language in Calcutta, the capital of British colonial rule, thrived from the mid-nineteenth century though they did not include women performers till 1874. The story of the early actresses is difficult to trace due to a lack of evidence in contemporary sources. So though a researcher is vaguely aware of their significance and contribution to Indian theatre, they have remained shadowy figures – nameless except for those few who have left a written testimony of their lives and activities. It is my intention through the study of this primary material and the scattered references to these legendary actresses in vernacular journals and memoirs, to recreate the stories of some of these divas and draw a connection between testimony and lasting memory. ***Memória e testemunho escrito: as atrizes do teatro público em Calcutá nos séculos XIX e XX***As representações teatrais modernas na língua bengali em Calcutá, a capital do governo colonial britânico, prosperaram a partir de meados do século XIX, embora não incluíssem mulheres até 1874. É difícil traçar a história das primeiras atrizes devido à falta de evidências em fontes contemporâneas. Dessa forma, embora o pesquisador tenha uma vaga consciência de sua contribuição e importância para o teatro indiano, elas permaneceram obscuras – anônimas, com exceção daquelas que deixaram um testemunho escrito de suas vidas e atividades. Por meio do estudo desse material primário e das referências esparsas a essas lendárias atrizes em diários e memórias na língua vernácula, pretendo recriar as histórias de algumas dessas divas e estabelecer uma conexão entre testemunho e memória duradouraPalavras-chave: Atrizes; Teatro bengali; Párias sociais; Representação e produção criativa; Memória e testemunho escrito.
The Factors Influencing the Non-Performing Assets in the Indian Banking Sector: An Economic Analysis
Authors: .N Bhaarathi , Thilagavathi M.
Published: October 2018

Non-Performing Assets are a burning topic of concern for the public sector banks, as managing and controlling NPA is very important. The current paper with the help of secondary data, from RBI website, tried to analyse the 8 years, (2010-2018) net non-performing asset data of 26 public sector banks, by using Hausman test statistics, and with the help of Stata software. The main objective of the study is to find out the factors influencing the Non-Performing Assets in the Indian Banking Sector. This paper also focuses on the reason behind the NPA and its impact on banking operations.
The nature of renaissance antiquarianism: History, methodology, definition*
Authors: Acciarino Damiano
Published: October 2018

The aim of this work is to provide a possible definition for Renaissance antiquarianism. This cultural pathway, which influenced the way the past was interpreted between the fourteenth and seventeenth centuries, represented a methodological perspective which involved the cross-referencing of heterogeneous sources, strongly linked to mankind’s perception of time and that helped shape a renewed historical consciousness. Focus will be devoted to a possible history of the phenomenon and a general explanation of its methodology.
Einsatz von Bisphosphonaten beim Pferd – eine Literaturübersicht
Authors: Düsterdieck-Zellmer Katja
Published: October 2018

Tiludronsäure bzw. Clodronsäure führt bei einigen Pferden mit Podotrochlosesyndrom zur Linderung der Lahmheit. Der Therapieeffekt tritt meist 2–6 Monate nach Gabe des Medikaments ein. Bei Pferden ohne Verbesserung der Lahmheit kann eine Folgebehandlung doch noch die Lahmheit verringern. Pferde mit einer Erkrankungsdauer von weniger als 6 Monaten haben eine bessere Chance auf Behandlungserfolg. Bisphosphonate (BP) können Nierenschäden hervorrufen, weshalb es sich empfiehlt, die Nierenfunktion vor und nach der Behandlung zu untersuchen. Pferde mit Nierenschäden sollten nicht mit BP behandelt werden, weil diese Substanzen eine weitere Beeinträchtigung der Nierenfunktion verursachen können. Deshalb sollen BP auch nicht zusammen mit nichtsteroidalen Antiphlogistika oder anderen nephrotoxischen Medikamenten verabreicht werden. Eine der häufigsten Nebenwirkungen nach BP-Applikation ist Kolik. Eine konservative Behandlung mit Führen im Schritt reicht meist aus. Falls eine medikamentöse Behandlung nötig wird, sollte diese mit N-Butylscopolamin, Xylazin, Detomidin oder Butorphanol (möglicherweise auch in Kombinationen) erfolgen. Die Verabreichung nichtsteroidaler Antiphlogistika wird nicht empfohlen. Bei Auftreten von Muskelfaszikulationen sollten die Plasmaelektrolytwerte bestimmt werden. Die Verabreichungsweise von BP-Produkten sollte den Empfehlungen der Herstellerfirmen folgen. Lokale Applikationen wie intraartikuläre Injektionen oder Verabreichung per Stauungsinfusion an den distalen Gliedmaßen sind möglicherweise schädlich und zurzeit nicht zu empfehlen.
Feldstudie zum freien Abferkeln im Kaltstall
Authors: Erhard Michael , Kickstein Janina , Bergmann Shana , Klein Sandrina , Patzkéwitsch Dorian
Published: October 2018

Ziel dieser Feldstudie war, in einem nach den BIO-AUSTRIA-Produktionsrichtlinien wirtschaftenden ökologischen Ferkelerzeugerbetrieb von Sommer 2015 bis Sommer 2017 das vorhandene freie Abferkel-system hinsichtlich der Praxistauglichkeit zu überprüfen, vor allem aber die Ferkelverluste und deren Ursachen zu erfassen. Die sogenannte „Ethobox” (HAKA, Josef Häufele GmbH & Co. KG, Erbach-Dellmensingen, Deutschland) war in zwei Kaltställen mit Ausläufen installiert. Material und Methoden: Die Reproduktionsrate wurde routinemäßig über Stallkarten erfasst. Ferkelverluste wurden in erdrückte Ferkel oder sonstige Verluste eingeteilt und der Zeitpunkt des Verlusts vermerkt. Ergebnisse: Die Datenerfassung erstreckte sich auf 490 Würfe (Sau: Deutsches Edelschwein x Deutsche Landrasse; Eber: Pietrain/Pietrain x Duroc; durchschnittliche Wurfnummer: 2,5 ± 1,3; durchschnittliche Anzahl lebend geborener Ferkel: 10,5 ± 2,8; durchschnittliche Anzahl tot geborener Ferkel: 0,8 ± 1,7). Im Mittel wurden 0,72 Ferkel pro Wurf erdrückt. Die sonstigen Ferkelverluste lagen bei 0,58 Ferkeln pro Wurf. Die Gesamtferkelverlustrate betrug 12,4 %. In der 1. Lebenswoche wurden 98,6 % der Verluste durch Erdrücken dokumentiert. Die sonstigen Verluste machten in diesem Zeitraum einen Anteil von 53,1 % aus. Schlussfolgerung und klinische Relevanz: Die Studie bestätigt, dass die 1. Lebenswoche als “kritische Lebensphase” der Ferkel in Bezug auf Erdrückungsverluste anzusehen ist. Nach den Resultaten hat sich die untersuchte freie Abferkelbucht für den Betrieb als praxistauglich erwiesen. Vor allem die niedrige Anzahl lebend geborener Ferkel dürfte in Bezug auf die vergleichsweise geringen Ferkelverluste eine wesentliche Rolle spielen.
Intradermale versus intramuskuläre Impfstoffapplikation bei Saugferkeln
Authors: Göller Manuel , Fels Michaela , Gerdts Wiebke-Rebekka , Kemper Nicole
Published: October 2018

Ziel dieser Studie war, eine intradermale Impfmethode gegen Mycoplasma hyopneumoniae bei Saugferkeln im Hinblick auf Hautreaktionen, Leistungsparameter und arbeitstechnische Gesichtspunkte mit einer konventionell durchgeführten intramuskulären Impfung wissenschaftlich zu vergleichen und mögliche Konsequenzen für das Wohlbefinden der Tiere abzuleiten. Material und Methoden: Unter Feldbedingungen wurden insgesamt 672 Saugferkel aus drei Durchgängen geimpft, davon 338 intradermal und 334 intramuskulär. Neben einer umfassenden Bonitur wurde die lokale Hautreaktion an der Impfstelle bonitiert, indem die Größe der Schwellung (Scoring 0–5) sowie die Rötung und Krustenbildung (Scoring 0–3) benotet wurden. Die Ferkel wurden am Tag vor der Impfung und 8 Tage später einzeln gewogen. Ferner erfolgten eine Messung und Dokumentation der für die jeweilige Impfung benötigten Zeit. Ergebnisse: Am 1. Tag nach der Impfung zeigten 71,3 % der intramuskulär geimpften Ferkel und 2,7 % der intradermal geimpften Ferkel keine Schwellung an der Impfstelle. Diese Unterschiede nivellierten sich mit zunehmendem zeitlichem Abstand zur Impfung. Die tägliche Gewichtszunahme der Ferkel differierte zwischen der intradermal (248 g) und der intramuskulär (258 g) geimpften Gruppe nicht signifikant. Die intradermale Impfung benötigte pro Ferkel im Schnitt 11 Sekunden, die intramuskuläre Impfung 17 Sekunden. Schlussfolgerungen und klinische Relevanz: In dieser ersten Studie konnten keine nachteiligen Effekte der intradermalen Impfung auf Leistungsparameter und keine länger anhaltenden Hautreaktionen bei Saugferkeln nachgewiesen werden. An den Hautreaktionen zeigte sich sehr gut die bei der intradermalen Impfung gewünschte Immunantwort an der Impfstelle, die nach 7 Tagen aber nicht mehr offensichtlich war. Darüber hinaus stellte sich der arbeitstechnische Vorteil der intradermalen Impfung klar heraus. Um letztendlich mögliche Vorteile hinsichtlich der Auswirkungen auf das Wohlbefinden von Saugferkeln zu evaluieren, sind weitere Analysen anhand von Videobeobachtungen erforderlich.
METHODOLOGY OF DETERMINING THE PARAMETERS OF TRACTION ELECTRIC MOTOR FAILURES WHEN OPERATING TROLLEYBUSES
Authors: Pavlenko T. P. , Shavkun V. M. , Scurihin V. I. , Lukashova N. P.
Published: October 2018

Purpose. The work is aimed to study the change in parameters of traction electric motors of trolleybuses during operation and improvement of the technical state control system, using modern diagnostic methods. Methodology. Solution of the scientific problem is based on the control of technical state and change in the parameters of traction electric motors in the process of operation. For analysis of operational factors, we used the method of mathematical statistics and probability theory. Mathematical modelling and design of experiment, multifactor regression analysis provides an assessment of the reliability of the electric traction motor elements. Physical and statistical methods provide for research and detection of patterns of influence of the factors that accelerate the wear of parts. This allows us to generate models of system reliability that take into account the influence of operational factors on the reliability. Findings. As a result of the studies we obtained quantitative characteristics of the reliability of commutator and established that the failures of traction motors make up 20% of all failures of electrical equipment. We analysed the operation conditions of traction electric motors and determined the failure distribution law N{mx,sx}, which allows assessing the progression between gradual failures. We obtained a mathematical model characterizing the object operation. A generalized equation of the failure rate of elements for traction electric motor (TEM) was found. We improved the estimation methods of reliability of TEM element base that makes it possible to determine the ETM lifetime taking into account the features of each trolleybus. We established the failure rate of commutators using physical and statistical methods. Originality. For the first time, the choice of physico-statistical methods of simulation and reliability calculation was substantiated. We determined the regularities of change in parameters of the trolleybus traction electric motor elements, which makes it possible to control the processes of their wear in the operation conditions. We developed a mathematical model for estimating the traction electric motor reliability, based on a system analysis of the probabilities of failures of subsystems to be diagnosed. Practical value. Based on the results of the study, we developed practical recommendations for rational choice of diagnostic parameters of traction motors. Their implementation at the enterprises of electric transport will increase reliability of electric motors in general up to 10%. It is proposed to use the results of the work in the educational process and in the research work of students at the Department of Electric Transport of the O.M. Beketov National University of Urban Economy in Kharkiv. The developed methodology for determination of parameters of traction electric motors when operating trolleybuses allows assessing the reliability of any type of trolleybus traction motor.
SENSITIVITY OF STRESSES TO THE FORCES ACTING ON THE CAST PARTS OF FREIGHT-CAR BOGIE
Authors: O. G. Reidemeister  , O. A. Shykunov
Published: October 2018

Purpose. To determine the effect of the force components acting in the axle box and the central spring suspension on the stresses occurring in the solebar of the three-piece bogie. Methodology. To assess the effect of the forces acting on the solebar on the stresses in it, we developed a finite element model of the solebar. After that, we carried out an assessment of its stress-strain state under loading conditions corresponding to the І and ІІІ design modes. According to the results obtained, we determined the stress concentration points in the construction, which are selected as check ones for further studies. Also, as checkpoints we took the points corresponding to the sensor locations when estimating the stresses in the solebar during the tests. At the next stage, we applied unit loads in sequence at the interaction points of the solebar with the boxes and the central spring group. To obtain a more accurate result, the unit forces were balanced by the corresponding forces and moments of inertia. With each loading variant, tensors of stresses arising from the action of unit loads were obtained at checkpoints. On the basis of the stress tensors obtained, we determined the corresponding equivalent stresses - the sensitivity coefficients. Findings. The paper determines the stress sensitivity coefficients in the three-piece bogie solebar to external loads acting on the solebar from the side of axle box and central spring group. Based on the results of the assessment of the coefficients obtained, we determined the forces having the greatest influence on individual sections of the solebar. We estimated the possibility of using the obtained results in optimizing the parameters of the bogie spring suspension to increase the strength and durability of the solebar. Originality. For the first time, the effect of individual components of the forces acting on the solebar on the stresses in it has been estimated. Practical value. The obtained result can be used in the design and optimization of three-piece bogies, to improve the solebar durability. The stress tensors obtained can be used to estimate the effect of complex loading on the solebar strength and durability.
From Religion to Pragmatism: Habayit Hayehudi’s Attitude toward Judea and Samaria
Authors:   University of Wroclaw (Poland), Pokrzywiński Paweł
Published: October 2018

Judea and Samaria became a really important element in Israeli right-wing and religious debate following the Six Day War because the State of Israel began to control it militarily and politically and started settling in this area. Nonetheless, Judea and Samaria had a deeper meaning within Religious Zionist ideology and its main representative Mafdal (NRP). After 1967 Religious Zionists were also influenced by the Messianic ideology, thus biblical territories accelerate Redemption. Hence, the NRP insisted on creating and developing Jewish settlements in Judea and Samaria, both in leftist and rightist governments. The situation has changed since the Oslo Accords and Sharon’s disengagement from Gaza. Both were shocking for the Religious Zionism camp, the state was no longer a steady defender of Jewish settlements. In 2008 the Mafdal was absorbed by the newly created Habayit Hayehudi (the Jewish Home) which was treated as a hope for Religious Zionism to restore its former glory. The head of the Jewish Home – Naftali Bennett – called his party a real right-wing camp. He is thought to be a representative of settlers but he also tries to widen his electorate with secular citizens. Habayit Hayehudi is the best example of a party which wants to achieve ideas of Religious Zionism in the new political reality after Oslo. The article will analyze the attitude of the Jewish Home party towards Judea and Samaria and the party’s ideological course.
Matrilineality as a Historical and Cultural Context of Ethical Reflection on the Use of In Vitro Fertilization in Israel
Authors:   Wrocław University of Science and Technology (Poland), Marcinów Teresa
Published: October 2018

On one hand, Israel is a leader in the field of high-tech industry, but on the other, it remains a country focused on traditions. In Vitro Fertilization (IVF) is one of the most common treatments among many possibilities which were created in the field of assisted reproductive technology (ART). Indeed, the number of Jewish women as intensive consumers of IVF has increased in the past few years. Due to the great importance of motherhood and raising families in Jewish tradition, Israel strongly supports health care procedures assisting Jewish adults in becoming parents. There is no doubt that for Jews life is the most precious value in its religious and political meaning, however, they are quite flexible in accommodating modern technologies in order to serve life. The State has historically focused on increasing birthrates and nowadays a woman’s biological clock is an important element not only in the context of matrilineal descent and for the answer to the question of Jews identity but it is also intervening as a part of the reproductive industry.
Fabián Gandini y la est(ética) de la fisura
Authors:   Universidad Nacional de San Martín, Vallejos Juan Ignacio
Published: October 2018

During 2015, I collaborated with the Argentine choreographer Fabian Gandini in the production of his last work “En la boca de la tormenta [In the mouth of the storm]”. Gandini is among the first artists to develop the “non-dance” choreographic movement in Buenos Aires, the city where he has lived and worked since 2004. My purpose in this paper will be to describe and analyze Gandini’s artistic practice in terms of a “Aesth-ethics of Fissure” linked not only to a poetical singularity but also to a critic of local dance productive practices. By using the temporal perception and the stilling of movement as dramaturgical resources, Gandini tends to subvert a strong legacy of expressionism. I would like to argue that his choreographic work embodies a political statement in the institutional context of Buenos Aires’ contemporary dance by exposing a specific form of “performative fragility” that establishes itself at the frontier of theatrical fiction.
Ritualizar la muerte. Identidades latinoamericanas en las prácticas conceptuales de Alfredo Portillos
Authors:   Universidad de Buenos Aires, Universidad Nacional del Arte, Universidad Nacional de Tres de Febrero, Pérez Juan Pablo
Published: October 2018

How to reinterpret Latin American identity discourses which were present in the artistic and political practices of the 1970s? How to revaluate their achievements and reinterpret them in the neo-liberal and globalized world of the 1990s, based on selected aesthetic propositions of an Argentinian artist, Alfredo Portillos? How are the emancipatory powers of such practices reactivating and functioning in the contemporary context? The proposed theoretical reflection on the artistic activity of Alfredo Portillos aims at reinterpreting the processes of circulation, valorisation and reception of some works which were omitted during creation of a historiographic account of “Grupo de los Trece” and then CAyC (Buenos Aires). The proposed reflections refer to different scopes of regional aesthetics in search for identity in Latin America and their connections with various political contexts. The narrative identity was accepted by the artist for the first time in 1973, when during the fourth edition of “Salón Premio Paolini”, he presented a work showing an acrylic hermitage. A title of the work, which appeared in the catalogue of “Funerary urn of those who died for liberation of Latin America” (Urna funeraria de los caídos por la Liberación Latinoamericana), was very meaningful. This first semantic and conceptual proposition, including curiosity of matter characteristic of folk religiosity has become an element present in all the rituals presented by Alfredo Portillos (also in the latest one).
Teatro y posdictadura: La Organización Negra y sus modos de intervenir el espacio público en clave performática
Authors:   Universidad de Buenos Aires, González María Laura (Malala)
Published: October 2018

This article investigates about two temporal space coordinates: Buenos Aires in the Postdictatorship. It dates from the Argentine democratic oncoming of December 1983, when that socio-cultural landscape of the city warned against changes and modifications respect to its previous period. Expanding into a multiplicity of artistic micropoetics, several theatre groups and collectives emerged in unconventional and peripheral areas of the city, attempting to reclaim the acceptance of stifled expression that existed during the previous years of the military dictatorship (1976-1983). The Organización Negra is one of these groups. In this article, we intend to address some aspects of its centripetal trajectory (1984-1992), which began in the margins of the theatrical field and culminated with the group’s admission into a space belonging to the official theatrical circuit. At each stage, we intend to investigate the different modes of production, circulation and consumption of their practices. In other words, we observe the procedural aspects that –in pursuit of strengthening and generating their own poetics– were kept (or not) even when the spaces of action have been modified; and we analyze the intersections between art, politics, and the city that were established depending upon each historical moment. Thus, this study aims to record The Organización Negra’s theatrical work, but also to establish its connections with contemporary poetics.
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis
Authors: Branco Luciana Prats , Adoni Tarso , Apostolos-Pereira Samira Luisa , Brooks Joseph Bruno Bidin , Correa Eber Castro , Damasceno Carlos Augusto , Eboni Audred Cristina Biondo , Fezer Leticia , Gama Paulo Diniz da , Goncalves Marcus Vinicius Magno , Gomes Sidney , Grzesiuk Anderson Kuntz , Mendes Maria Fernanda , Morales Rogerio Rizo , Muniz Andre , Parolin Monica Fiuza Koncke , Pimentel Maria Lucia Vellutini , Ribeiro Marlise de Castro , Santos Gutemberg Augusto Cruz dos , Sato Henry Koiti , Scherpenhuijzen Simone Batista , Scorcine Claudio , Siquineli Fabio , Sousa Nise Alexandra de Carvalho , Varela Daniel Lima , Winckler Tereza Cristina Avila , Fragoso Yara Dadalti
Published: October 2018

ABSTRACT Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by the reactivation of the John Cunningham virus (JCV). Objective: To identify the serologic profile of JCV in patients with MS. Methods: Data on serum antibodies for JCV were obtained using the enzyme-linked immunosorbent assay provided by the STRATIFY-JCV program. Results: A total of 1,501 blood tests were obtained from 1,102 patients with MS. There were 633 patients (57.1%) who were positive for antibodies for JCV and 469 patients who were negative (42.9%). Twenty-three patients became positive after initially having negative JCV antibody status. The rate of seroconversion was 18.5% over 22 months. Conclusion: The JCV serologic profile and seroconversion in Brazilian patients were similar to those described in other countries.
Is self-report sleepiness associated with cognitive performance in temporal lobe epilepsy?
Authors: Vascouto Helena Dresch , Thais Maria Emília Rodrigues de Oliveira , Osório Camila Moreira , Ben Juliana , Claudino Lucia Sukys , Hoeller Alexandre Ademar , Markowitsch Hans J. , Wolf Peter , Lin Katia , Walz Roger
Published: October 2018

ABSTRACT Sleepiness and cognitive impairment are common symptoms observed in patients with epilepsy. We investigate whether self-reported sleepiness is associated with cognitive performance in patients with refractory mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Seventy-one consecutive patients with MTLE-HS were evaluated with the Stanford Sleepiness Scale (SSS) before neuropsychological evaluation. Their mean SSS scores were compared with controls. Each cognitive test was compared between patients with (SSS ≥ 3) or without sleepiness (SSS < 3). Imbalances were controlled by regression analysis. Patients reported a significantly higher degree of sleepiness than controls (p < 0.0001). After multiple linear regression analysis, only one test (RAVLT total) remained associated with self-reported sleepiness. Conclusion: Self-reported sleepiness was significantly higher in MTLE-HS patients than controls, but did not affect their cognitive performance. If confirmed in other populations, our results may have implications for decision making about sleepiness screening in neuropsychological settings.
Anxiety and knowledge of patients before being subjected to orthognathic surgery
Authors: Barel Pâmella Simões , Sousa Cristina Silva , Poveda Vanessa de Brito , Turrini Ruth Natalia Teresa
Published: October 2018

ABSTRACT Objective: to verify the correlation between anxiety level and degree of knowledge in patients before they are subjected to orthognathic surgery. Method: Descriptive cross-sectional study with 40 patients in the preoperative period before orthognathic surgery of a private clinic in the city of São Paulo. Results: IDATE-trait anxiety levels feature prevalence of medium-level anxiety with 72.5% (n=29), followed by low-level anxiety with 72.5% (n=29) and high-level level anxiety with 10% (n=4). In the pre-operative period, transitory IDATE-state anxiety levels feature medium-level anxiety with 65% (n=26), followed by high-level anxiety with 22.5% (n=9) and low-level anxiety with 10% (n=4). Pearson’s correlation coefficient resulted in negative r (−0.2) for anxiety-trait (p 0.197) and in negative r (−0.1) for anxiety-state (p 0.417). Conclusion: The data shows a weak correlation in which greater knowledge about the surgical procedure reduces levels of anxiety that may be related to the absence of appropriate guidance about the surgical procedure.
Indicators of burnout in Primary Health Care workers
Authors: Garcia Gracielle Pereira Aires , Marziale Maria Helena Palucci
Published: October 2018

ABSTRACT Objective: to analyze the indicators of burnout peculiar to health workers from units of Primary Health Care. Method: integrative review of the literature structured in the stages: guiding question; search; categorization of studies; assessment; discussion; and interpretation of results, and synthesis of knowledge. Search for original articles and reviews published from 2000 to 2016, in Portuguese, English and Spanish, in the main databases of the health area. Descriptors used: Nursing, Burnout and Primary Health Care. Results: 14 articles met the proposed inclusion criteria, six (42.85%) presented a sample of nurses and eight (57.15%) health professionals. Conclusion: Primary Health Care workers are exhausted due to inadequate working conditions characterized by the lack of human and physical resources that leads to work overload, workplace violence and difficulty with teamwork, despite being satisfied with the work environment.
Experiencing suicide in the family: from mourning to the quest for overcoming
Authors: Dutra Kassiane , Preis Lucas Corrêa , Caetano Jaqueline , Santos José Luís Guedes dos , Lessa Greice
Published: October 2018

ABSTRACT Objective: to understand the family’s experience of losing a family member by suicide. Method: study with qualitative approach with reference of the Constructivist Grounded Theory. The theoretical sample consisted of 20 participants, among health professionals and family members of people who committed suicide. Data were collected through intensive and coded interviews from initial and focused coding. Results: three categories were obtained: Being in a “state of shock”; Living with the suffering and effects of the loss of the family member; and, Rebuilding life. From the articulation of these categories emerged the phenomenon: “Experiencing the loss of a family member by suicide: from mourning to the quest for overcoming”. Final considerations: each category represents a stage in the family’s experience of losing a family member by suicide. The results provide support for suicide prevention and postvention actions developed by health professionals.
Ombudsman’s experience in Psychosocial Care Centers for alcohol/drugs
Authors: Bittencourt Marina Nolli , Oliveira Diúlia Cristina Pantoja de , Souza Ruan Patrick de Oliveira , Pena José Luís da Cunha , Pantoja Paulo Victor das Neves , Pereira Maria Odete
Published: October 2018

ABSTRACT Objective: The objective of the study was to analyze criticisms, compliments and suggestions of users, family and workers, placed in an Ombudsman of a Centro de Atenção Psicossocial para Álcool e outras Drogas (Psychosocial Care Centers for Alcohol and Other Drugs- CAPS ad). Method: A study carried out in the CAPS ad of Macapá-AP from August to December 2016, through the thematic content analysis of the files deposited in the ombudsman, recently introduced in the service, containing criticisms, compliments and suggestions from users, family members, and CAPS ad. Results: It was observed the dissatisfaction with the infrastructure of the CAPS ad, and with the relationships built between users and professionals, in addition, suggestions were given of workshops, and improvement in the development of the Projeto Terapêutico Singular (freely translated as Unique Therapeutic Project). Final considerations: It is concluded that the multidisciplinary team needs to put in practice the real psychosocial care in the service, and that the management helps in the improvement of the service’s place, and in the proposal of qualifications to this team.
Night beds in psychosocial attention care centers for alcohol and drugs: analysis and characterization
Authors: Boska Gabriella de Andrade , Oliveira Márcia Aparecida Ferreira de , Claro Heloísa Garcia , Araujo Thalita Silva Gomes de , Pinho Paula Hayasi
Published: October 2018

ABSTRACT Objective: To analyze and characterize the use of night beds in a Psychosocial Attention Care Center for Alcohol and Drugs (Centro de Atenção Psicossocial Álcool e Drogas – CAPS ad). Method: It is a quantitative, documental, descriptive and retrospective study. Data were gathered from 565 medical records. An analysis of continuous variables was performed. Results: When admitted to the beds, most users (87.6%) consumed multiple substances daily and were vulnerable, specially in street situation (68.3%). These users were admitted on an average of two times, undergoing a previous evaluation by the nurse (85.8%), usually for detoxication or due to the vulnerable condition. They stayed in the center for an average of seven days and 31.1% did not finish what was proposed. For a few cases, hospital support was needed. Overall, discharges were planned, but the return happened without booking. Conclusion: Social issues cut through the use of night beds, however, it is a therapeutic resource that meets significant demands and is present in the daily lives of vulnerable users as a comprehensive care.
“Um lugar fora de lugar”: a mulher e o sertão em Maria Valéria Rezende
Authors: Santini Juliana
Published: October 2018

Resumo Este trabalho propõe uma reflexão sobre o deslocamento da personagem feminina no romance Outros cantos, de Maria Valéria Rezende. O objetivo é problematizar de que modo a representação do sertão articula-se, na narrativa, à composição de uma protagonista que, sendo mulher, narra sua própria viagem e coloca em perspectiva presente e passado. Entra em questão, nesse caso, não apenas a figura feminina, mas também os significados atribuídos ao sertão na ficção brasileira contemporânea.
Ante el teatro, en el museo, desde el archivo: modos escénicos (y autorales) del arte contemporáneo
Authors: Pinta María Fernanda , Garbatzky Irina
Published: October 2018

Resumen En la exhibición Mínimo teatral (Museo Macro, Rosario, 2017) trabajamos, en tanto curadoras, sobre las resonancias del teatro en el arte contemporáneo, explorando distintos modos de apropiación de la teatralidad y la puesta en escena. Teníamos la intención de propiciar un diálogo entre artes visuales y escénicas, aún cuando los intercambios no se produjeran en términos de referencia y/o comentarios de uno con respecto al otro. Al mismo tiempo, no pretendíamos formular una historia del arte (historia del campo visual y teatral, historia de sus conversaciones, historia de sus desencuentros), aunque hiciéramos una pregunta por los usos del archivo y sus efectos en una posible conceptualización del tiempo. El presente trabajo busca tramar un relato y una reflexión sobre aquella experiencia. Las preguntas son: ¿Qué zonas (sensibles, sociales, productivas) abre el pensamiento del teatro? ¿Cuáles son los efectos del montaje y del archivo teatral en el museo? ¿Cuáles serían los efectos sobre la conceptualización y los usos del tiempo? Y finalmente, qué implicancias sobre la curaduría arrojó la investigación y las hipótesis arriesgadas para la muestra, tanto en lo concerniente al diálogo teatro/artes como al punto de vista adoptado respecto del archivo.
No meio do caminho tinha um CAPSAD: centralidade e lógica assistencial da rede de atenção aos usuários de drogas
Authors: Costa Pedro Henrique Antunes da , Ronzani Telmo Mota , Colugnati Fernando Antonio Basile
Published: October 2018

Resumo O presente estudo objetiva avaliar, através da Análise de Redes Sociais (ARS), o papel do Centro de Atenção Psicossocial - Álcool e outras Drogas (CAPSad) sobre a rede de atenção aos usuários de drogas. Trata-se de uma pesquisa exploratória, de corte transversal e abordagem quantitativa na rede de Juiz de Fora, Minas Gerais. Nela, foram identificados 187 serviços assistenciais no município. A coleta de dados foi feita a partir de questionário com profissionais destes dispositivos. A análise levou em consideração métricas de coesão e centralidade da ARS, bem como a confecção de sociogramas da rede. Constatou-se uma centralidade da rede no CAPSad, em conformidade com as políticas e o modelo assistencial preconizado na área, nomeada de “CAPSolização”. A centralização neste dispositivo, ainda em número insuficiente e com problemas estruturais e na dinâmica de trabalho, influi para um baixo poder de resiliência da rede e indica a necessidade de modificação da lógica assistencial, ainda pautada pelo cuidado especializado, de urgência, em detrimento de perspectivas territorializadas/comunitárias e contínuas.
Governança regional do sistema de saúde no Brasil: configurações de atores e papel das Comissões Intergovernamentais
Authors: Albuquerque Mariana Vercesi de , Lima Luciana Dias de , Oliveira Ricardo Antunes Dantas de , Scatena João Henrique Gurtler , Martinelli Nereide Lucia , Pereira Adelyne Maria Mendes
Published: October 2018

Resumo O foco da análise é o papel exercido pelas Comissões Intergestores Regionais, considerando a diversidade de atores que influenciam a política de saúde em contextos regionais específicos. A pesquisa envolveu a realização de cinco estudos de caso em cada uma das macrorregiões brasileiras, com aplicação de 128 questionários a gestores, prestadores e representantes da sociedade civil, entre agosto de 2015 e agosto de 2016. Adotou-se a perspectiva comparada, considerando três eixos de análise: configurações de atores (governamentais e não governamentais; públicos e privados) nas decisões e conflitos regionais, dinâmica de funcionamento e atuação, e contribuições das comissões para a política e a organização do sistema de saúde. Verificou-se a diversidade de atores com alto grau de influência nas regiões e a função das Comissões Intergestores Regionais na coordenação das políticas e na resolução de conflitos. Estas favorecem a negociação intergovernamental e a organização do Sistema Único de Saúde frente à estrutura federativa brasileira. Contudo, possuem atuação limitada como espaço de governança regional da saúde, sendo incapazes de incorporar as diversas configurações de atores públicos e privados com poder e influência sobre as decisões de saúde.
Entre o suporte e o controle: a articulação intersetorial de redes de serviços
Authors: Avelar Mariana Rossi , Malfitano Ana Paula Serrata
Published: October 2018

Resumo Redes sociais, especificamente de articulação entre serviços das políticas sociais, são incentivadas como forma de aumento da efetividade das ações, podendo promover maior suporte social, devendo ser implementadas pela gestão pública. Contudo, elas podem também produzir controle da vida dos pobres. Objetivou-se mapear as redes sociais em Campinas-SP, e investigar a estratégia de articulação entre os serviços das políticas de assistência social, educação e saúde como possível instrumento de suporte social. Para tanto, foram entrevistados 13 dos 15 coordenadores distritais das políticas sociais, aplicado questionários com terapeutas ocupacionais, com a colaboração de 47,2% (n = 17) das profissionais municipais e realizada observação de duas redes por quatro meses. Foram mapeadas 78 redes, com predominância no setor da saúde. Foram discutidas as categorias: O que é rede? Quem realiza as ações em rede? Quais as atribuições da rede? Suporte social ou controle? Conclui-se que há um distanciamento entre discurso e prática. Por um lado, há consenso em torno da necessidade das redes; por outro, não se possibilita mudanças institucionais para sua efetivação. Além de sua função parecer ser ambivalente, uma vez que procuram garantir suporte, são também dispositivos de controle.
Governança e suporte da rede social secundária na atenção à saúde de crianças e adolescentes com doenças crônicas
Authors: Nóbrega Vanessa Medeiros da , Souza Maria Helena do Nascimento , Santos Mariana Matias , Silva Maria Elizabete de Amorim , Collet Neusa
Published: October 2018

Resumo Estudo de abordagem qualitativa com o objetivo de analisar as características estruturais dos sistemas de governança e suporte ofertado pela rede social secundária na atenção à saúde de crianças e adolescentes com doença crônica. Pesquisa realizada em unidades da Estratégia Saúde da Família, ambulatório especializado e hospital público pediátrico de João Pessoa - PB, de fevereiro a outubro de 2013, por meio de entrevista semiestruturada e grupo focal. Participaram do estudo: 06 gestores, 14 profissionais de saúde e 12 familiares cuidadores de crianças ou adolescentes com doenças crônicas. Os dados foram analisados seguindo-se os princípios da análise temática de conteúdo. Na atenção à saúde das crianças e adolescentes com doenças crônicas evidenciou-se o sistema de governança do tipo colaborativo, bem como limitações da governança pública do tipo gerencial, que fragilizam a rede social secundária com repercussões no suporte oferecido aos familiares e na articulação entre os serviços. Conclui-se que essa realidade pode apresentar impacto negativo na qualidade e efetividade do cuidado prestado às crianças e adolescentes em condição crônica, por não atender as reais necessidades dessa população.
Movimento social de mulheres com HIV/AIDS: uma experiência entre cidadãs “posithivas” do Rio de Janeiro, Brasil
Authors: Cajado Luciana Corrêa de Sena , Monteiro Simone
Published: October 2018

Resumo Diante do papel histórico da sociedade civil organizada nas respostas sociais à aids e na governança global em saúde, o artigo analisa a biografia de mulheres com HIV/aids, integrantes do Movimento Nacional das Cidadãs Posithivas (MNCP), uma rede nacional de mulheres soropositivas. Utilizou-se abordagem qualitativa, com observações das ações do MNCP no Rio de Janeiro e entrevistas individuais com oito integrantes do MNCP, sobre suas motivações e experiências no movimento. A maioria das entrevistadas tinha mais de 50 anos e foi diagnosticada na década de 1990. Suas biografias foram marcadas por desigualdades sociais e de gênero. A entrada no MNCP resultou da necessidade de suporte pós-diagnóstico do HIV e do pouco acolhimento nos serviços de saúde. O movimento contribuiu para reconstrução da identidade social, acesso a informação sobre cuidado e apoio social. Segundo os achados, as ações do movimento não priorizam pautas do movimento feminista e o enfrentamento do estigma da aids e das condições de vulnerabilidade ao HIV. Frente ao atual contexto, global e nacional, de recrudescimento de intervenções biomédicas nas políticas de aids e da redução de recursos para o movimento social, o estudo fomenta reflexões sobre os desafios da sociedade civil organizada nas respostas sociais locais a epidemia de aids.