bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-valent Titanium Induced Reductive Coupling of Diaryl Diselenides with Acid Chlorides or Acid Anhydrides: Facile Synthesis of Selenoesters
Authors: Zhou Long-Hu , Zhang Yong-Min
Published: June 2021

Selenoesters have been prepared in good yield by reaction of diaryl diselenides with acid chlorides or acid anhydrides induced by the TiCl4–Sm–THF system under mild reaction conditions.
Nitriding of 304 Steel by a Nitrogen Plasma: Increasing Corrosion Resistance
Authors: Bellakhal N. , Draou K. , Brisset J. L.
Published: June 2021

Exposure of a 304 stainless steel sample to an inductively coupled low pressure radio frequency (RF) nitrogen plasma leads to the formation of a nitriding layer. The protective properties of this layer are investigated by electrochemical methods. The corrosion potential of the steel in an aqueous solution depends on the working parameters of the plasma such as the time exposure and the distance between the steel sample and the high voltage (HV) coil of the treatment reactor.
Syntheses and Antibacterial Activities of Tizoxanide, an N-(Nitrothiazolyl)salicylamide, and its O-Aryl Glucuronide
Authors: Rossignol Jean-François , Stachulski Andrew V.
Published: June 2021

Mild hydrolysis of the broad-spectrum anaerobic antibacterial and antiparasitic agent nitazoxanide 1 affords tizoxanide 2, which is a major metabolite of 1 retaining most of its activity; further metabolism of 2 leads to the O-aryl glucuronide 3, efficiently synthesised in four steps from benzyl salicylate and showing slight antibacterial activity.
Insertion of N=N and O=O Bonds in Tin and Lead Allyl Bonds in Metalloene Reactions Catalysed by Lithium Perchlorate
Authors: Kinart Wojciech J. , Tylak Izabela , Kinart Cezary M.
Published: June 2021

A new example of catalysis by lithium perchlorate of metalloene reactions with singlet oxygen and diethyl azodicarboxylate is reported in which the insertion of N=N and O=O bonds in Sn and Pb allyl bonds is possible.
13C and 1H NMR Spectra of Synthetic (25R)-5α-Spirostanes
Authors: Arteaga Martín A. Iglesias , Martinez Carlos S. Pérez , Gil Roxana Pérez , Manchado Francisco Coll
Published: June 2021

The assignment of 13C and 1H NMR signals of synthetic (25 R)-5α-spirostanes is presented; the main effects on chemical shifts due to substitution at C-23 are briefly discussed.
Synthesis and Characterization of Organochromium Complexes fac-Cr(CO)3(dppe)(η2-C60), fac/mer-Cr(CO)3(dppe)(η2-C60) and fac-Cr(CO)3(L)(dppe) (L = PPh3, 4-MeC5H4N)
Authors: Song Li-Cheng , Zhu Ying-Huai , Hu Qing-Mei
Published: June 2021

Reaction of fac-Cr(CO)3(MeCN)(dppe) [dppe = 1,2-bis(diphenylphosphino)ethane] or Cr(CO)4(dppe) with fullerene C60 afforded a single isomer fac-Cr(CO)3(dppe)(η2-C60) and an isomeric mixture of fac/mer-Cr(CO)3(dppe)(η2-C60), whereas the isomer fac-Cr(CO)3(dppe)(η2-C60) reacted with Ph3P or 4-methylpyridine to give single isomers fac-Cr(CO)3(Ph3P)(dppe) and fac-Cr(CO)3(4-MeC5H4N) (dppe), respectively.
A Reversed-phase HPLC Study of the Complexation of Benzene Derivatives Guest Molecules with 5,17-bis(N-Tolyliminomethyl)-25,27-dipropoxycalix[4]arene in Acetonitrile–Water Solution
Authors: Kalchenko O. I. , Solovyov A. V. , Lipkowski J. , Kalchenko V. I.
Published: June 2021

Stability constants of the host–guest complexes of 5,17-bis( N-tolyliminomethyl)-25,27-dipropoxycalix[4]arene with benzene derivatives were determined by reversed-phase HPLC in acetonitrile–water solution.
Thermally Unstable 5-(9-Anthrylmethyl)-10-methyl-5,10-dihydrophenazine
Authors: Sugimoto Akira , Matsumoto Keisuke , Maruyama Hideyuki , Mizuno Kazuhiko , Uehara Kaku
Published: June 2021

The title compound in refluxing toluene decomposed to 9-anthrylmethyl derivatives and phenazine as major products upon cleavage of the N–CH2 bond; the orbital interaction of which with π-orbitals of the aromatic ring was suggested by the X-ray crystal structure analysis.
Synthesis and Reactivity of 3-Alkylthio-5-cyanomethyl-4-phenyl-1,2,4-triazoles
Authors: Mekheimer Ramadan A. , Shaker Rafat M.
Published: June 2021

Phenyl isothiocyanate reacts with 2-cyanoacetohydrazide (1) to yield the corresponding 1-cyanoacetyl-4-phenylthiosemicarbazide (3), via acid hydrolysis of the intermediate 2 whereas cyclization of 3 gave the 1,2,4-triazoles 4, 1,3,4-thiadiazoles 7 and 1,3,4-thiadiazine-5-ones 9; compound 4a was reacted with phenyl isothiocyanate, dicyandiamide, sulfanylacetic acid and benzaldehyde to afford 11, 13, 14 and 15, respectively.
Evaluation of Transannular Interaction of [2.3] Metacyclophane-diazonium Tetrafluoroborate and its Dediazoniated Derivatives
Authors: Moriguchi Tetsuji , Yasutake Mikio , Sakata Kazunori , Tsuge Akihiko
Published: June 2021

Transannular interactions of [2,3] metacyclophane-diazonium tetrafluoroborate and its dediazoniated derivatives have been evaluated by 1H NMR, IR, UV and stability constant determination.
Synthesis of Bridged Oligophenylenes from Fluorene. Part 2.1 Quinquiphenyls to Deciphenyls
Authors: Kelley Charles J. , Ghiorghis Alem , Qin Yuanxi , Kauffman Joel M. , Novinski John A. , Boyko Walter J.
Published: June 2021

Organometallic derivatives of aryl bromides 2a–10a have been coupled with aryl dihalides 11–16 in the presence of PdCI2(dppb) catalyst to produce symmetrical bridged oligophenylenes 17–31 and 33 that contain five to ten conjugated benzene rings with one to four dialkylmethylene bridges; these products show useful solubility, high quantum efficiency of fluorescence and good photochemical stability.
Experiments towards the Synthesis of the Ergot Alkaloids and Related Structures. Part 7.1 Novel Syntheses of some 4-Acyl-2,3,4,4a,5,6-hexahydrobenzo[f]quinolin-2-ones
Authors: Bowman Mark A. E. , Bowman Ralph E.
Published: June 2021

Reaction of the N-formyl enol-lactone 4 and the corresponding N-acetyl 10 and N-methoxycarbonyl 11 derivatives with bis(trimethylsilyl)potassiomalonate in THF at 60°C followed by treatment with aqueous sodium hydrogen carbonate and cyclisation as above, yielded the 4-formyl-, 4-acetyl- and 4-methoxycarbonyl-tricyclic ketones 7, 13 and 14 in yields of 31, 35 and 36%, respectively.
A Convenient Synthesis of (±)-3-Methoxybenzodioxane-4,9,9-triol Neolignan, and Methyl Ethers of Isoamericanol A and Isoamericanin A
Authors: She Xuegong , Gu Wenxin , Wu Tongxing , Pan Xinfu
Published: June 2021

The (±)-3-methoxybenzodioxane-4,9,9′-triol neolignan 9, and methyl ethers of isoamericanol A 8 and isoamericanin A 7 were synthesized from the readily available materials caffeic acid and ferulic acid, using a coupling reaction as a key step.
n-Butyltriphenylphosphonium Peroxodisulfate (BunPPh3)2S2O8: An Efficient and Inexpensive Reagent for the Cleavage of Carbon–Nitrogen Double Bonds under Non-aqueous and Aprotic Conditions
Authors: Mohammadpoor-Baltork Iraj , Hajipour Abdol Reza , Haddadi Reza
Published: June 2021

An efficient and convenient conversion of oximes, phenylhydrazones, p-nitrophenylhydrazones and semicarbazones to the corresponding carbonyl compounds with n-butyltriphenylphosphonium peroxodisulfate is reported.
Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents
Authors: Granero Gladys E. , de Bertorello María M. , Briñón Margarita C.
Published: June 2021

The synthesis of three new isoxazolylnaphthoquinones with an ethyl group on the isoxazole ring is reported.
A Facile One-pot Synthesis of Pyrido[2,3-d]-pyrimidines and Pyrido[2,3-d:6,5-d‘]dipyrimidines
Authors: Youssif Shaker , El-Bahaie Said , Nabih Esam
Published: June 2021

The reactions of enaminones (6-aminouracils) 1a–c and 4 with cyano olefins 2a–b and 5a–f led to the formation of pyrido[2,3- d]pyrimidines. 3a–f and 6a–f in good yield, while the treatment of 4-amino-2-thiouracil 4 with aromatic aldehydes afforded pyridodipyrimidines 7a–c.
Solvent-assisted Carboxylation of Alkali Metal Phenoxide with Carbon Dioxide
Authors: Kosugi Yoshio , Takahashi Kazufumi , Imaoka Yoshio
Published: June 2021

The carboxylation of alkali metal phenoxide with carbon dioxide gives not only ortho- but also para-hydroxybenzoic acids at room temperature, unlike the well-known Kolbe–Schmitt reaction.
Oxidation of 2-Alkylcycloalkanones with Iodine–Cerium(IV) Salts in Alcohols
Authors: He Liangyou , Kanamori Miyuki , Horiuchi C. Akira
Published: June 2021

The reaction of 2-alkylcycloalkanones with iodine–cerium(IV) salts in alcohols (methanol, ethanol, propan-1-ol or propan-2-ol) gave the respective oxo ester in 28–98% yields.
Chiral β-Sulfinylamines as Ligands for Enantioselective Addition of Diethylzinc to Benzaldehyde
Authors: Chan Wing Hong , Lee Albert W. M. , Lin Jing
Published: June 2021

Chiral β-sulfinylamines 4a, 6a, 6b, 8a, 8b and 9b were synthesized and assessed in the enantioselective addition of diethylzinc to benzaldehyde.
Zinc(II)-driven Fluorescence Quenching of a Pyrene-labelled Bis-2,2′-bipyridine Ligand
Authors: Sohna Jean-Ernest Sohna , Jaumier Pascale , Fages Frédéric
Published: June 2021

The title compound has been synthesized and its fluorescence emission is quenched upon complexation of the Zn2+ in methanol solution.
Triethylamine-promoted Elimination from (R,R)-PhCHORCHCICO2Me (R = MeCO, PhCO, 4-MeC6H4, 4-MeOC6H4, MeSO2 and 4-MeC6H4SO2) in Various Solvents
Authors: Montani Rosana S. , Gil Elisabet , Cabaleiro Mercedes C.
Published: June 2021

The rates and stereochemistry of elimination from a number of ( R,R)-PhCHORCHCICO2Me (R = MeCO, PhCO, 4-MeC6H4, 4-MeOC6H4, MeSO2 and 4-MeC6H4SO2) with triethylamine in tetrahydrofuran, acetone, methanol, dimethylformamide and acetonitrile as solvents led to the conclusion that the elimination process occurs through an (E1cB)l mechanism.
Synthesis of α-Phenylthioacylmethylene Triphenylarsoranes and their Wittig-type Reactions
Authors: Deng Gui-Sheng , Huang Zhi-Zhen , Yu Xiao-Chun , Huang Xian
Published: June 2021

α-Phenylthio acylmethylene triphenylarsoranes, the first stable α-thiyl arsonium ylides, are prepared by phenylsulfenylation–transylidation reaction of the corresponding acylmethylene triphenylarsoranes with phenylsulfenyl chloride; Wittig reactions are carried out under mild reaction conditions on the arsonium ylides to provide α-phenylthio-α,β-unsaturated ketones.
Kinetic Isotope Effects in the Chromium(VI) Oxidation of Bicyclic Alcohols
Authors: Markgraf J. Hodge , Dubow Jordan S. , Charland Jessica A. , Sohn Elliott H.
Published: June 2021

Pseudo first-order rate constants are determined for the oxidation of a series of secondary alcohols and their monodeutero analogues by ammonium chromate in aqueous acidic solution at several temperatures; the relative rates and activation parameters are consistent with a cyclic, symmetrical transition state.
Correlation of the Rates of Solvolysis of Methyl Chloroformate with Solvent Properties
Authors: Kevill Dennis N. , Kim Jong Chul , Kyong Jin Burm
Published: June 2021

The specific rates of solvolyis of methyl chloroformate are very well correlated by the extended Grunwald–Winstein equation over a wide range of solvents; the pathway is believed to be predominantly addition–elimination, except that a positive deviation for solvolysis in 90% 1,1,1,3,3,3-hexafluoropropan-2-ol suggests an 80% contribution from an ionisation mechanism.
Microwave-assisted Efficient Synthesis of Alliodorin and (±)-Curcuhydroquinone
Authors: Kad Goverdhan L. , Khurana Anupam , Singh Vasundhara , Singh Jasvinder
Published: June 2021

Terpenoids 1 and 2 have been synthesized from readily available starting materials using Li2CuCI4-catalysed coupling of Grignard reagents with alkyl/aryl bromides and microwave-assisted oxidation of allylic methyl groups, using SeO2/ButOOH adsorbed over SiO2 as key steps.
Sodium Periodate Epoxidation of Alkenes Catalysed by Manganese Porphyrins
Authors: Mohajer Daryoush , Tayebee Reza , Goudarziafshar Hameed
Published: June 2021

Epoxidation of alkenes with different electronic and steric properties has been performed with high selectivity by sodium periodate in the presence of acetatotetraarylporphinatomanganese(III) complexes containing electron releasing or withdrawing groups at the ortho positions of the aryl rings, in a two-phase (CH2CI2–H2O) medium at 24 ± 2 °C.
Kinetics and Mechanism of Oxidation of Aliphatic Aldehydes by Benzyltrimethylammonium tribromide
Authors: Goswami Garima , Kothari Seema , Banerji Kalyan K.
Published: June 2021

The oxidation of aliphatic aldehydes by benzyltrimethylammonium tribromide involves the formation of an intermediate complex and its subsequent decomposition in the rate-determining step to the corresponding carboxylic acid.
Kinetics and Mechanism of Oxidation of Diols by Hexamethylenetetramine-bromine
Authors: Gangwani Hemlata , Sharma Pradeep K. , Banerji Kalyan K.
Published: June 2021

The oxidation of vicinal diols by hexamethylenetetramine-bromine (HABR) proceeds by a glycol-bond fission via an intermediate complex whereas non-vicinal diols behave like monohydric alcohols towards HABR.
1,3-Dipolar Cycloaddition of Four Hydrazonoyl Chlorides to β-Diketones and α,β-Unsaturated Ketones
Authors: Albar Hassan A.
Published: June 2021

The 1,3-dipolar cycloaddition of four hydrazonoyl chloride derivatives with the sodium salt of unsymmetrical β-diketones (benzoylacetone) offers a versatile method for the regioselective synthesis of 2 H-pyrazoles in a similar fashion to the cycloaddition of the nitrilimides with α,β-unsaturated ketones and esters; the structures of the prepared isomeric pyrazole and pyrazoline derivatives are established by spectroscopic and chemical methods.
Reactions with Hydrazonoyl Halides. Part 21. Reinvestigation of the Reactions of Hydrazonoyl Bromides with 1,1-Dicyanothioacetanilide
Authors: Abdelhamid Abdou O. , Zohdi Hussein F. , Rateb Nora M.
Published: June 2021

The reaction of C-(benzoyl) -N- (phenyl) formohydrazonoyl bromide with 1,1-dicyanothioacetanilide was reinvestigated. The product was elucidated on the basis of elemental analysis, spectral data and alternative synthesis. Also, reaction of hydrazonoyl halides with different thioanilides were investigated.
Palladium(II)-catalysed Intramolecular Oxypalladation/Functionalisation of Carbohydrate-derived Cyclic Alkenes. Regioselective Formation of Substituted Di- and Tetra-hydropyrans
Authors: Holzapfel Cedric W. , Marais Lizel
Published: June 2021

A palladium (II)-promoted domino process converts easily prepared pseudoglycals into highly functionalised, chiral di-and tetra-hydropyran structures in high yields.
The Reaction of 3,4-Epoxy-5-hydroxyandrostanes with Hydrobromic Acid
Authors: Baldwin Derek , Hanson James R. , Uyanik Cavit
Published: June 2021

The formation of aromatic and ketonic products from the treatment of 17β-acetoxy-3α,4α-epoxy-5α-hydroxyandrostane and its 3β,4β-epoxy-5β-hydroxy isomer with hydrobromic acid in glacial acetic acid is discussed in the context of the diaxial and diequatorial opening of the epoxide.
Synthesis and Photoreactivity of a 2-Pivaloylcyclohex-2-enone
Authors: Ferrer Leticia Oliveira , Margaretha Paul
Published: June 2021

2-Pivaloylcyclohex-2-enone 4, obtained from 2,2-dimethylcyclohexanone in three steps in 70% yield, is converted into tetrahydrobenzo[ c]furan-4-one 6 on irradiation (254 nm) in propan-2-ol.
Polymer Supported Chromium Peroxide Complexes for the Selective Oxidation of Alcohols
Authors: Lakouraj M. Mansour , Keyvan A.
Published: June 2021

Poly(2-vinylpyridine)(I) and poly(4-vinylpyridine)(II) supported chromium peroxide reagents are readily prepared and used as mild, efficient, selective and easy to handle oxidizing agents for oxidation of benzylic and allylic alcohols.
Reactions of Sodium Salts of 3-(Hydroxymethylene)alkan-2-ones with Enamines: Synthesis of Polysubstituted Pyridines
Authors: Elgemeie Galal H. , Metwally Nadia H.
Published: June 2021

Reactions of sodium salts of 3-(hydroxymethylene)alkan-2-ones with enamines afford 3-cyano-2-(disubstituted-methylene) -1,2-dihydropyridines.
Reduction of Arylsulfonyl Derivatives with the Sm/Cp2TiCl2 System. A Novel Method for Preparation of Disulfides
Authors: Huang You , Guo Hongyun , Zhang Yongmin , Wang Yulu
Published: June 2021

The Sm/Cp2TiCI2 system reduces arylsulfonyl derivatives to the corresponding disulfides in good yield in refluxing THF.
Synthesis of Danielone (α-Hydroxyacetosyringone)
Authors: Luis Javier G. , Andrés Lucía S.
Published: June 2021

An efficient simple three step synthesis of the phytoalexin danielone (α-hydroxyacetosyringone) from acetosyringone is described.
Synthesis, Reactivity and Crystal Structure of a Novel Cluster [Co3(CO)9(μ3-C)C(O)OCH2]2
Authors: Zhang Ji , Chen Xue-Nian , Ding Er-Run , Yuan-Qi-Yin  , Sun Jie
Published: June 2021

The higher-nuclearity cluster compound [Co3(CO)9(μ3-C)C(O)OCH2]2 1 has been isolated from the reaction of [CI3CC(O)OCH2]2 and Co2(CO)8, and its metal exchange reaction with Na[M(CO)3{Sex5-C5H4C(O)C6H4C(O)OMe}] (M = Mo or W) has been discussed together with its structure determination by single-crystal X-ray diffraction methods.
Structure and (Hyper)polarizabilities of Five-membered Heterocycles C4H4XH2 (X=C, Si, Ge, Sn)
Authors: Millefiori Salvatore , Alparone Andrea , Millefiori Arcangelo
Published: June 2021

Calculated HF/POL and B3LYP/POL linear and quadratic polarizabilities of C4H4XH2 (X=C, Si, Ge, Sn) increase remarkably with the atomic number of X.
Organic Synthesis with Anion Exchange Resins: Synthesis of α-Imino Nitriles from Nitrones
Authors: Konwar Dilip , Goswami Birendra Nath , Borthakur Naleen
Published: June 2021

Nitrones react with amberlite IRA 400 [CN-] in acetonitrile to produce α-iminonitriles in good yield.
Vilsmeier Reaction on Carbazole: Theoretical and Experimental Aspects
Authors: Das Gourab Kanti , Choudhury Bijali , Das Kalpita , Das Basudeb Prasad
Published: June 2021

The pathway of the Vilsmeier reaction on carbazole has been studied by AM1 semiempirical MO calculations, which includes the characterization of the various transition structures; an experimental study of the actual reaction shows the formation of diformyl derivative along with a monoformyl derivative.
The Preparation and Microbiological Hydroxylation of the Sesquiterpenoid Nootkatone
Authors: Arantes Simone F. , Farooq Afgan , Hanson James R.
Published: June 2021

The sesquiterpenoid nootkatone has been prepared from valencene by copper (I) iodide catalysed oxidation with tert-butyl hydroperoxide and hydroxylated at C-9 by Mucor plumbeus and Cephalosporium aphid/cola.
Interesting Synthetic Approaches towards [1] Benzopyrano[4,3-b]quinolines via Intramolecular Reaction of Nitrilium Salts
Authors: Ibrahim Yehia A. , Moustafa Ahmed H.
Published: June 2021

The o-allyloxybenzanilides 2a,b,d and o-propargyloxybenzanilides 3a–f are prepared and converted to the corresponding dihydro[1]benzopyrano[4,3- b]quinolinium hexachloroantimonate 6a and [1] benzopyrano[4,3- b] quinolines 9a–e, 10 upon treatment with PCI5 followed by SbCI5.
Preparation of Cyclopentenones by Benzeneseleninic Anhydride Oxidation of Cyclopentanones
Authors: Dragojlovic Veljko
Published: June 2021

Cyclopentanones are treated with benzeneseleninic anhydride in refluxing benzene and the corresponding cyclopentenones are obtained in moderate to good yields.
8-Mesityl-8-borafluorazene: A BN-heterocyclic Benzopentalene
Authors: Albrecht Karsten , Kaufmann Dieter E.
Published: June 2021

8-Mesityl-8-borafluorazene, a formally anti-aromatic benzopentalene, is prepared by cyclization of 2,2′-dilithio-1-phenylpyrrole with dimethoxymesitylborane.
Preparation of tert-Butyl 6-Aminopenicillanate and its 6-Oxo and 6-Diazo Derivatives
Authors: Veinberg Grigory , Vorona Maxim , Musel Dan , Grigan Nora , Lukevics Edmunds
Published: June 2021

A 1:1 1,4-dioxane– tert-butyl acetate mixture and BF3 etherate were used for an effective 6-aminopenicillanic acid conversion into the tert-butyl ester (64 ± 3% yield) which could be easily transformed into tert-butyl 6-oxo- and 6-diazo-penicillanates.
A Stereoselective Synthetic Route to (Z)-1-Arylthio Vinylstannanes
Authors: Huang Xian , Zhong Ping
Published: June 2021

Acetylenic stannanes react with Cp2Zr(H)CI (Cp = η5-C5H5) to give organozirconium(IV) complexes, which are trapped with arylsulfenyl chloride to afford ( Z)-l-arylthio vinylstannanes.
Preparation of α-Heteroatom Substituted Allylic Alcohols by Reaction of (E)-α-Selanylvinylzirconiums or (E)-α-Trimethylsilylvinylzirconiums with Aldehydes
Authors: Huang Xian , Sun Ai-Ming
Published: June 2021

Both ( E)-α-selanylvinylzirconium and ( E)-α-trimethylsilylvinylzirconium complexes undergo AgClO4-catalyzed reactions with aldehydes to give α-seleno- or α-trimethylsilyl-substituted allylic alcohols, respectively.
Copper(II) Chloride Dihydrate: A Catalytic Agent for the Deprotection of Tetrahydropyranyl Ethers (THP Ethers) and 1-Ethoxyethyl Ethers (EE Ethers)
Authors: Wang Jianbo , Zhang Chao , Qu Zhaohui , Hou Yihua , Chen Bei , Wu Peng
Published: June 2021

Tetrahydropyranyl ethers (THP groups) and 1-ethoxyethyl ethers (EE groups) are removed upon refluxing in 95% EtOH or Me2CO–H2O (95:5) in the presence of a catalytic amount of copper(II) chloride dihydrate (2–5 mol%).
Oxidation of Nickel(II) Cyclam and Tetraglycine Complexes by Dissolved Oxygen in the Presence of Sulfur(IV). Synergistic Effects of Manganese(III) and Cobalt(III)
Authors: Pezza Helena Redigolo , Bonifácio Rodrigo Leandro , Coichev Nina
Published: June 2021

The autoxidation of [NiII(cyclam)]2+ (cyclam = 1,4,8,11 -tetraazacyclotetradecane) and NiIItetraglycine, accelerated by SIV, is studied spectrophotometrically by following the formation of NiIII complexes.
Acid-catalysed Condensation of Ethyl 5-Acetoxymethyl-4-acetyl-3-methylpyrrole-2-carboxylate and its Analogues with Aromatic Substrates
Authors: Chunchatprasert Laddawan , Shannon Patrick V. R.
Published: June 2021

The 5-acetoxy-4-acetylpyrrole 1 and its derivatives show a range of reactivity towards various aromatic substrates giving pyrroloindoles and pyrrolo [3,2- b] carbazoles amongst other products.
Neighbouring Group Participation in the Methanolysis of a Vicinal Diepoxide
Authors: Hanson James R. , Hitchcock Peter B. , Kiran Ismail
Published: June 2021

The tetracyanoethylene catalysed methanolysis of 17β-acetoxy-4β,5β:6α,7α-diepoxyandrostane afforded 17β-acetoxy-4α,7α-oxido-5β-hydroxy-6β-methoxyandrostane in which the methanolysis product of the 6α,7α-epoxide has participated in the cleavage of the 4β,5β-epoxide; the reaction is modified however by an adjacent 3β-hydroxy group.
1,3-Dipolar Cycloadditions of Some Nitrilimines and Nitrile Oxides to 3-N,N-Dimethylamino-1 -oxopropene Derivatives
Authors: Al-Zaydi Khadijah Mohamed , Hafez Ebtisam Abdel Aziz
Published: June 2021

An efficient synthesis of some novel pyrazoles 8a-j, 13a-e, 18a,b, isoxazoles 26a-g, pyrazolo[3,4- d]pyridazines 9a-d and isoxazolo[3,4- d]pyridazines 27a-d via 1,3-dipolar cycloaddition reactions is reported.
Bromination of Naphthalene. Preparation of 1,3-Dibromonaphthalene
Authors: Cakmak Osman
Published: June 2021

Photobromination of naphthalene with molecular bromine gives only one stereoisomer α,2β,3χ,4β-tetrabromo-1,2,3,4-tetrahydronaphthalene (yield 90%); dehydrobromination of which results in the formation of 1,3-dibromonaphthalene in 88% yield.
A New and Efficient One-pot Synthesis of Trialkyl 6-tert-Butylamino-2H-pyran-2-one-3,4,5-tricarboxylates
Authors: Yavari Issa , Esmaili Abbas Ali , Asghari Sakineh , Bijanzadeh Hamid Reza
Published: June 2021

The highly reactive 1:1 intermediate produced in the reaction between tert-butyl isocyanide and dialkyl acetylenedicarboxylates is trapped by dialkyl 2-bromomalonates to yield the title compounds in fairly high yields.
Hydrotalcite Clay-catalysed Air Oxidation of Thiols
Authors: Hirano Masao , Monobe Hiroyuki , Yakabe Sigetaka , Morimoto Takashi
Published: June 2021

Hydrotalcite is an efficient catalyst for air oxidation of a variety of aromatic, aliphatic and alicyclic thiols in hexane, affording the corresponding disulfides in excellent to quantitative yields under mild and neutral conditions.
Ring-Chain Tautomerism of the 1,4-Oxathiane S,S-Dioxide Anion
Authors: Hammad Nashwa , Sutherland Alan G.
Published: June 2021

The ring-chain tautomer of the α-sulfonyl anion of 1,4-oxathiane S,S-dioxide can be trapped by addition of alkoxides to the vinyl sulfone; the scope of this reaction is explored.
Simple Synthesis of 2-Acetyl-5,8-dimethoxy-3,4-dihydronaphthalene: A Key Intermediate for the Synthesis of 4-Demethoxydaunomycinone
Authors: Chavan Subhash P. , Subbarao Y. Tripura , Gopal Chittiboyina Amar
Published: June 2021

2-Acetyl-5,8-dimethoxy-3,4-dihydronaphthalene is prepared by using a 1,3-dipolar cycloaddition of nitrile oxide to the corresponding dihydronaphthalene.
Novel Synthesis of 5-Amino-1-arylsulfonyl-4-pyrazolin-3-ones as a New Class of N-Sulfonylated Pyrazoles
Authors: Elgemeie Galal H. , Metwally Nadia H.
Published: June 2021

A novel synthesis of 5-amino-1-arylsulfonyl-4-pyrazolin-3-ones via intramolecular cyclization of cyanoaceto- N-arylsulfonylhydrazides is reported and the synthetic potential of the method is demonstrated.
Hypervalent Iodine in Synthesis Part 39. Palladium-catalyzed Carbonylative Coupling of lodonium Salts and Potassium Aryltrifluoroborates by Carbon Monoxide
Authors: Xia Min , Chen Zhenchu
Published: June 2021

Diaryl ketones and chalcones are obtained in good yields by palladium-catalyzed carbonylative coupling of diaryliodonium salts and ( E)-phenylethenyl(phenyl)iodonium tetrafluoroborates with potassium aryltrifluoroborates in an atmosphere of carbon monoxide under mild conditions.
A Simple Synthetic Route to Pterosin F and Other Pterosins
Authors: Finkielsztein Liliana M. , Alesso Elba N. , Lantaño Beatriz , Aguirre José M. , Iglesias Graciela Y. Moltrasio
Published: June 2021

A simple method for the preparation of pterosin F is described in which the key step involves a tandem reaction of Friedel–Crafts acylation–cycloalkylation between 2,6-dimethylphenethyl chloride and ethyl methacrylate
Efficient One Step Transformation of Carboxylic Acids to Nitriles with the Carbon Chain Shortened by One Carbon Atom
Authors: Smushkevich Y. I. , Smushkevich V. Y. , Usorov M. I.
Published: June 2021

Nitrozation of ω-substituted alkanoic acids of the general formula X(CH2) nCO2H (X = CI, CO2H, CO2Me, PhthN), bulky substituted alkanoic acids, arylacetic acids containing electron withdrawing substituents in the aromatic ring, o-tosylhydroxyphenylacetic acids and N-phtaloilaminophenylacetic acids yield nitriles with the carbon chain shortened by one (or two for dicarboxylic acids) carbon atom.
C–H/N–H Tautomerism of Tetrakis-(2-benzothiazolyl)ethane
Authors: Boga Carla , Bonamartini Anna Corradi , Forlani Luciano , Mezzina Elisabetta , Pompa Andrea , Sgarabotto Paolo , Spinelli Domenico , Todesco Paolo E.
Published: June 2021

C–H and N–H tautomers of the title compound are obtained and their structural properties determined by 1H and 13C NMR spectroscopy and X-ray diffraction; solvent and base effects on the rate of the C–H to N–H transformation are investigated.
Evidence of the Existence of 2:1 Guest–Host Complexes between Diclofenac and Cyclodextrins in D2O Solutions. A 1H and 13C NMR Study on Diclofenac/β-Cyclodextrin and Diclofenac/2-Hydroxypropyl-β-cyclodextrin Systems
Authors: Mucci Adele , Schenetti Luisa , Vandelli Maria A. , Ruozi Barbara , Forni Flavio
Published: June 2021

The interaction of diclofenac sodium salt (DCFNa) and two cyclodextrins, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD), studied in D2O solution with different NMR techniques (1H, 13C NMR, ROESY experiments, NMR titrations), shows the existence of multiple equilibria involving 1:1 and 2:1 guest–host complexes.
The First Example of a Structurally Characterized Monomeric Bismuth Selenolate
Authors: Mugesh G. , Singh Harkesh B. , Butcher Ray J.
Published: June 2021

The reaction of intramolecularly coordinating 2-(4,4-dimethyloxazolino)phenyl selenolate ligand with anhydrous BiCl3 (3:1 equivalents) produces the monomeric, air stable, homoleptic bismuth(III) selenolate complex.
Synthesis and Characterisation of Nickel(II) Diphenylalkenylphosphine Complexes
Authors: Coles Simon J. , Faulds Paul , Hursthouse Michael B. , Kelly David G. , Ranger Georgia C. , Walker Neil M.
Published: June 2021

Nickel(II) phosphine complexes are prepared with a series of diphenylalkenylphosphine ligands and characterised by single crystal X-ray diffraction and spectroscopic techniques.
Hypervalent Iodine in Synthesis. Part 42: A General Method for Stereospecific Synthesis of S-Vinyl Dithiocarbonates
Authors: Yan Jie , Chen Zhen-Chu
Published: June 2021

S-Vinyl dithiocarbonates are prepared by the reaction of potassium dithiocarbonates with vinyl (phenyl)iodonium tetrafluoroborates in THF in good yields.
Thermal Stabilities and Kinetics of Desolvation of Related Inclusion Compounds of trans-9,10-Dihydroxy-9,10-diphenyl-9,10-dihydroanthracene
Authors: Coetzee Anita , Nassimbeni Luigi R. , Su Hong
Published: June 2021

The kinetics of desolvation of the inclusion compounds formed between the diol host and 2-, 3- and 4-methylcyclohexanones show a compensation effect in their Arrhenius parameters.
Synthesis of Novel Ferrocene–Naphthalimide Dyads
Authors: Wang Zhaohui , Zhu Jingwei , Chen Kongchang , Tian He
Published: June 2021

The synthesis of some novel ferrocene–naphthalimide dyads is described.
Trinuclear Comlexes of Palladium(II) Containing Bridging Thiolate and Pyrazolate Ligands
Authors: Singhal Anshu , Jain Vimal K.
Published: June 2021

Trinuclear palladium(II) complexes of the type [Pd3X2(μ-Y)2(μ-pz)2(PR3)2] [X = CI or Ph; Y = CI, SPh, SC6F5 or SC6H4C1-4; PR3 = PPh3 or P(tol)3] are prepared and characterised by elemental analyses, NMR (1H and 31P-{1H}) and FAB mass spectral data.
Circular Dichroic Properties of Flavan-3-ols
Authors: van Rensburg Hendrik , Steynberg Petrus J. , Burger Johann F. W. , van Heerden Pieter S. , Ferreira Daneel
Published: June 2021

CD data of all four diastereoisomers of the permethylaryl ether 3- O-acetyl derivatives of a series of flavan-3-ols permit assignment of the absolute configuration at the stereocentres of the heterocyclic ring.
Dimerisation of Knoevenagel Condensation Products obtained from Simple Unconjugated and α,β-Unsaturated Ketones
Authors: O'Callaghan Conor N. , McMurry T. Brian H.
Published: June 2021

The reaction of 3-acetyl-2 H-1-benzopyran-2-ones with malononitrile affords dicyanomethylene derivatives which dimerise to 1-amino-3,5,5-bis(2-oxo-2 H-1-benzopyran-3-yl)-5-methyl-1,3-cyclohexadiene-2,6,6-tricarbonitrile derivatives and related dimeric intermediate products.
Bimolecular Reactions of Mutagenic N-Acyloxy-N-alkoxybenzamides with Aromatic Amines
Authors: Campbell John J. , Glover Stephen A.
Published: June 2021

Mutagenic N-acyloxy- N-alkoxybenzamides undergo SN2 reactions at the amide nitrogen with N-methylaniline and ring-substituted anilines in reactions modelling the possible mode of interaction between the mutagens and nucleic acids and which may be responsible for their biological activity.
Synthesis of Bis-THF Compounds from D-Glucose
Authors: Sukkari Hanadi El , Renoux Brigitte , Bertrand Philippe , Gesson Jean-Pierre
Published: June 2021

Starting from diacetone-D-glucose, four diastereomeric bis-THF compounds related to annonaceous acetogenins are prepared using two strategies.
Preparation and Characterization of Complexes formed by the Reaction of Bis(4-hydroxyphenyl)-1,4-diazabuta-1,3-diene with Zinc, Cadmium and Mercury Chlorides
Authors: Farnia Morteza F. , Abedini Mansour , Pazukian Mohammad Ali
Published: June 2021

Complexes of bis(4-hydroxyphenyl)-1,4-diazabuta-1,3-diene with ZnII, CdII and HgII chlorides are synthesized; the complexes of ZnII and CdII are mononuclear with the ligand as a chelate, whereas the HgII complex is dinuclear with the ligand bridging two Hg nuclei.
Density Functional Theory and Complete Basis Set Ab Initio Computational Study of Five-, Six-, Seven- and Eight-hydrogen Coordinated Carbon Cations
Authors: Jursic Branko S.
Published: June 2021

High level ab initio and density functional theory studies are performed on highly protonated methane species.
Reactions of 1-(Benzotriazol-1-yl)-1-phenoxyalkane and (Benzotriazol-1-yl)ethoxy-phenylmethane Anions with Nitroarenes: A New Approach to Alkyl and Aryl p-Nitroaryl Ketones
Authors: Katritzky Alan R. , Chassaing Christophe , Toader Dorin , Gill Katherine
Published: June 2021

p-Nitroaryl alkyl ketones and p-nitroaryl aryl ketones are prepared regioselectively by reactions of non-functionalized nitroarenes and benzotriazole stabilized carbanions.
An Efficient One Pot Synthesis of Bicyclic Dienones
Authors: Rezgui Farhat , Gaïed Mohamed Moncef El
Published: June 2021

Bicyclic dienones 4 are prepared in a one pot process from the reaction of 2-(acetoxymethyl)cyclohex-2-enone 1 with 1,3-dicarbonyl compounds 2 in the presence of K2CO3 in refluxing absolute ethanol.
Synthesis and Characterization of Novel Acyclic Polyethers Containing Two Tetrahedral Cluster Moieties as Terminal Groups
Authors: Song Li-Cheng , Guo Dian-Shun , Hu Qing-Mei
Published: June 2021

Five novel acyclic cluster polyethers η5-C5H4CH2(CH2OCH2) nCH2C5H4-η5][MFeCoS(CO)8]2(M = Mo, W; n = 2,3; M = Mo, n = 4) are synthesized through double isolobal displacement reaction of (μ3-S)FeCo2(CO)9 with [η5-C5H4CH2(CH2OCH2) nCH2C5H4-η5][(CO)3MNa]2 and characterized by elemental analysis and spectroscopic techniques.
Preparation of a Series of N-Aryl-S,S-diphenylsulfilimines by Nucleophilic Attack of S,S-Diphenyl-sulfilimine on Activated Halogenoaromatic Compounds
Authors: Claridge Robert P. , Millar Ross W. , Sandall John P. B. , Thompson Claire
Published: June 2021

Some N-aryl- S,S-diphenylsulfilimines, most of which are novel compounds, are prepared and characterised, using a method based on nucleophilic attack of diphenylsuifilimine on activated aryl halides, especially polyhalogenated heterocyclic aromatic compounds.
Cyclen Phosphine Oxide: Hydrogen Bonding and Transannular N→P Interaction
Authors: Oget N. , Chuburu F. , Handel H. , Toupet L.
Published: June 2021

The crystal structure of cyclen phosphine oxide demonstrates the existence of an N→P interaction in the crystalline state.
Preparation of some Dihalogenodihydronaphthopyrans and Derivatives
Authors: Derrick Ian A. R. , Iqbal Muhammad , Livingstone Robert , McGreevy Bruce J.
Published: June 2021

The preparations of 3,4-dihalogeno-3,4-dihydro-2 H-naphtho[1,2- b]pyrans and 1,2-dihalogeno-2,3-dihydro-1 H-naphtho[2,1- b]pyrans and their conversion into some related naphthopyran derivatives are described.
Acylation of Heterocyclic Ketene Aminals with Benzoyl Chloride
Authors: Wang Jian-Chao , Wang Li-Ben , Huang Zhi-Tang
Published: June 2021

Heterocyclic ketene aminals 1 or 2 react with benzoyl chloride to give the regiospecifically mono- N-benzoylated products 5 or 6, while N-methyl heterocyclic ketene aminals 3 or 4 react under the same conditions, to give a more complex mixture of products.
Utility of 3-Aminocrotononitrile in the Synthesis of New Methyl 1,4-Dihydropyridine, Methylquinoline and Thiophene Derivatives: Reactivity of the Methyl Function in Alkyl 1,4-Dihydropyridine and Methyl Quinoline Derivatives towards Some Electrophilic Reagents
Authors: Hafiz Ibrahim Saad Abdel , Darwish Elham Sayed , Mahmoud Fivian Farouk
Published: June 2021

The methyl function in some newly prepared methyl 1,4-dihydropyridine and methyl quinoline derivatives proves to be highly active towards some electrophiles.
Boron Trifluoride-assisted Reactions of 1-Benzothiophen-3(2H)-one with Various Ketones: A Convenient Entry to 2-Methylene-1 -benzothiophen-3(2H)-one and/or 6H-Di[1]benzothieno[3,2-b:2,3-e]pyran Derivatives
Authors: Fraleoni Alessandro , Zanirato Paolo
Published: June 2021

The title compounds are obtained in moderate to high yields by BF3-assisted reaction of 1-benzothiophen-3(2 H)-one with nine ketones in diethyl ether at room temperature; the relative amounts of pyran 1 and ylidene 2 prove to be dependent upon electronic and steric factors.
1,4-Addition of N,N-Disubstituted Phenylacetamides to 2-Arylmethylene-1,4-butanolides
Authors: Cholakova Tzvetanka P. , Dobrev Alexander A. , Kanchev Assen B. , Mikhailova Petja P.
Published: June 2021

The 1,4-addition reaction of lithium derivatives of N,N-disubstituted phenylacetamides with 2-arylmethylene-1,4-butanolides gives the corresponding N,N-disubstituted 2-(1-aryl-2-carbamoyl-2-phenylethyl)-1,4-butanolides 3a–f as diastereoisomeric mixtures with 40–68% yields.
Inner-sphere Reduction of Tris(pyridine-2-carboxylato)manganese(III) by Glycolaldehyde in Sodium Picolinate–Picolinic Acid Buffer Medium
Authors: Gupta Kalyan Kali Sen , Begum Bilkis Ara
Published: June 2021

The reduction of tris(pyridine-2-carboxylato)manganese(III) by glycolaldehyde (GA) in sodium picolinate–picolinic acid buffer medium takes place by an inner-sphere mechanism
Synthesis of Cluster Derivatives Containing the MRuCoSe (M = Mo or W) Core
Authors: Zhang Yu-Hua , Wu Shu-Lin , Li Qing-Shan , Yin Yuan-Qi , Huang Xiao-Ying
Published: June 2021

The new clusters [MRuCo(CO)8(μ3-Se){η5-C5H4C(O)O Et}](M = Mo 2 or W 3) are isolated from the reaction of [RuCo2(CO)9(μ3-Se)] 1 and [M(CO)3{η5-C5H4C(O)OEt]-(M = Mo or W), and the structure of cluster 2 has been established by single crystal X-ray diffraction methods.
Aldol Condensation of Cycloalkanones with Aromatic Aldehydes Catalysed with TiCl3(SO3CF3)
Authors: Iranpoor N. , Zeynizadeh B. , Aghapour A.
Published: June 2021

Efficient cross-aldol condensation of cyclopentanone, cyclohexanone and 1-indanone with various aromatic aldehydes is catalysed with TiCl3(SO3CF3) at room temperature in excellent yields.
Regeneration of Aldehydes from Bisulfite Addition Products in the Solid State using Montmorillonite KSF Clay under Microwave Irradiation
Authors: Mitra Alok Kumar , De Aparna , Karchaudhuri Nilay
Published: June 2021

Microwave irradiation of bisulfite addition products with montmorillonite KSF clay under solvent-free conditions provides a fast, efficient and simple method for regeneration of aldehydes in excellent yields.
A Convenient and Mild Procedure for the Synthesis of Hydrazones and Semicarbazones from Aldehydes or Ketones under Solvent-free Conditions
Authors: Hajipour Abdol Reza , Mohammadpoor-Baltork Iraj , Bigdeli Mansour
Published: June 2021

Hydrazone and semicarbazone derivatives are readily prepared from the corresponding aldehydes or ketones, hydrazine derivatives and semicarbazides under solvent-free conditions.
Separation and Spectrophotometric Determination of Uranium in Caspian Sea Water
Authors: Amoli H. Salar , Rajabi M. , Mohanazadeh F.
Published: June 2021

Samples of Caspian sea water (from the Islamic Republic of Iran) were collected from a range of depths, up to 400 m, at 10 stations; uranium is successfully separated using a flotation technique and determined spectrophotometrically at 650 nm using arsenazo(III) as complexing reagent.
Synthesis of N-Phosphoamino Acids with Long Dialkoxy Chains
Authors: Deng Chang-Hui , Yan-Mei Li , Xu Ning , Zhao Yu-Fen
Published: June 2021

N-phosphoamino acids with long dialkoxy chains are synthesized and spectral data given.
Synthesis of Polyfunctional Aromatic Imines with Zwitterionic Character
Authors: Coen Serge , Martinet-Reboul Laurence , Périchaud Alain
Published: June 2021

Polyfunctional aromatic imines with a zwitterionic character involving sulfonic acid and N,N-dimethylamino functionalities are synthesized by oxidative condensation of 5-aminonaphthalene-2-sulfonic acid (Cleve's β-acid) and N,N-dimethyl- p-phenylenediamine.
Reductive Self Coupling of 4-Oxo-4H-1-benzopyran-3-carboxaldehyde
Authors: Bandyopadhyay Chandrakanta , Kumar Sur Ranabir , Das Hemanta Kumar
Published: June 2021

The title aldehyde 1 gives the bischromones 2, 3 and disalicyloylbenzene 5 with sodium naphthalenide; a mixture of 3 and chromanone 22 with zinc in methanol; 3, carbinol 6 and diol 8 with zinc in acetic acid; and acetates 7 and 9 with Zn-Ac2O-AcONa.
Bishomoisomandapamate, a New Tetracyclic Diterpenoid from a New Species of the Sinularia Genus of the Indian Ocean
Authors: Anjaneyulu Ammanamanchi S. R. , Sarada Putcha
Published: June 2021

Bishomoisomandapamate, a bishomologue of isomandapamate, has been isolated from a new species of Sinularia genus of the Indian Ocean and its structure elucidated.
Transannular Interactions and Reactions of the Dithia[3.3]metacyclophanediazonium Salt
Authors: Moriguchi Tetsuji , Sakata Kazunori , Tsuge Akihiko
Published: June 2021

The transannular interaction between two aromatic rings of the dithia[3.3]metacyclophanediazonium salt is evaluated by several spectral measurements and the dediazoniation of the salt preferentially affords the biphenyl compound.
AM1 Study of the Conformational Properties of (Z,Z)-Cyclonona-1,3-diene
Authors: Yavari Issa , Norouzi-Arasi Hassan , Fallah-Bagher-Shaidaei Hossain
Published: June 2021

The unsymmetrical boat-chair BC conformation of ( Z,Z)-cyclonona-1,3-diene is calculated to be 5 kJ mol−1 more stable than the axial-symmetrical twist-boat-chair TBC form; while the calculated energy barrier for limited pseudorotation of BC and TBC is only 10.2kJ mol−1, ring inversion of BC via plane-symmetrical boat geometry requires 24.4 kJ mol−1.
Improved Preparation of 6,13-Dichlorotriaryldioxazines using (Diacetoxyiodo)benzene
Authors: Xia Min , Ye Chunfang
Published: June 2021

6,13-Dichlorotriaryldioxazines (DCITADO) 1 have been synthesized from 2,5-bis(arylamino)-3,6-dichloro-1,4-benzoquinones (BADCIBQ) 2 by oxidation with (diacetoxyiodo)benzene (DIB) under mild conditions in good yields.
Hydroaminomethylation of Styrene with Morpholine catalysed by a Rhodium Complex with a Phosphino Amino Alcohol Ligand
Authors: Kostas Ioannis D.
Published: June 2021

Hydroaminomethylation of styrene with morpholine catalysed by a cationic rhodium complex with a P,N ligand possessing a hydroxy group and the influence of the temperature on the chemo- and regio-selectivity are described.
Synthesis of Convolutamydine A from Isatin
Authors: Jnaneshwar G. K. , Deshpande V. H.
Published: June 2021

Synthesis of the marine alkaloid convolutamydine A is described starting from commercially available isatin.
Synthesis of α, β-Unsaturated Selenoesters by the Reaction of Acylzirconene Chlorides with ArSeBr
Authors: Huang Xian , Liang Chun-Gen
Published: June 2021

α, β-Unsaturated selenoesters are prepared in good yields by the reaction of ArSeBr with acylzirconene chlorides.
Thienopyrimidines. Part III. Synthesis of Novel Substituted Thieno[2,3-d]pyrimidinone Derivatives and their Condensed Products with Molluscicidal and Larvicidal activities
Authors: Hosni Hanaa M. , Basyouni Wahid M. , El-Nahas Hanan A.
Published: June 2021

A range of novel substituted thieno[2,3- d]pyrimidinones are synthesized and screened for malluscicidal and larvicidal biological activity.
Benzotriazol-1-yl-Acetone as a Building Block in Heterocyclic Chemistry: A Route to Benzotriazolylpyridazines, Benzotriazolylphthalazines and Benzotriazolylpyrazolo[5,1-c]-1,2,4-triazines
Authors: Al-Naggar Abdul Aziz , Abdel-Khalik Mervat Mohammed , Elnagdi Mohammed Hilmy
Published: June 2021

Benzotriazolylacetone is coupled with aromatic diazonium salts to yield arylhydrazones, which can be condensed with ethyl cyanoacetate yielding pyridazinones whose reactivity towards activated double bond systems is investigated.
Synthesis of New Azoloazine Derivatives: New Routes to 1,2,4-Triazolo[4,3-a]pyrimidines, Pyrazolo[1,5a]pyridines and Pyrazolo [3,4-b]-pyridinones
Authors: Al-Saleh Balkis , Abdel-Khalik Mervat Mohammed , Al-Enzy Amal , Elnagdi Mohammed Hilmy
Published: June 2021

Azoloazines are produced via the reaction of aminoazoles with enaminones, enaminonitriles and ethyl alkylidene cyanoacetate.
Bicyclic Organophosphorus Amides. Nucleophilic Cleavage of 1-Oxo-2,3-benzo-10-phenyl-4,7,10-triaza-1λ5-phosphabicyclo-[5.3.0]decane and its p-Anisyl Analogues
Authors: He Zhengjie , Modro Tomasz A.
Published: June 2021

Methanolysis of the title substrates leads to different products depending on the conditions: in the presence of HCI both P–N bonds are broken yielding a non-cyclic phosphonic diester while the MeO- ion reacts selectively breaking the P–N(Ar) bond and yielding a cyclic, seven-membered phosphonic amidoester.
A Stereoselective Synthesis of (E)-Arylvinyl Selenides via Coupling of (E)-Vinylseleno Zirconocenes and Diaryliodonium Salts
Authors: Wang Jun-Hua , Xu Qing , Huang Xian
Published: June 2021

( E)-Arylvinyl selenides are prepared by coupling of ( E)-vinylseleno zirconocenes and diaryliodonium salts.
A Facile Synthesis of Symmetrical Dimeric Steroid-pyrazines
Authors: Şotowski Zenon , Gryszkiewicz Agnieszka , Borowiecka Jolanta B. , Nikitiuk Agnieszka , Morzycki Jacek W.
Published: June 2021

The reaction of steroidal 2α-bromo-3-ketones ( e.g. 2α-bromocholestan-3-one 2) with ammonia followed by hydrolysis and air-oxidation affords the easily separable mixture of the trans and cis dimeric steroid-pyrazines (3 and 4, respectively).
A Convenient One-pot Synthesis of Pyrimido[4,5-b]quinolines as 5-Deaza Non-classical Antifolate Inhibitors
Authors: Naby Hisham A. Abdel , Mekheimer Ramadan A. , Abd-Elhameed Afaf M. , Sadek Kamal U.
Published: June 2021

A convenient one-pot synthesis of pyrimido[4,5- b]quinolines as non-classical 5-deaza antifolate inhibitors by the reaction of 6-amino-4-oxo-2-thioxotetrahydropyrimidine 1 with aromatic aldehydes and dimedone is reported.
A Novel Synthesis of Unsymmetrical α-Amino Sulfides via the Sm/ZnCI2 System in THF-Water
Authors: Zheng Yunfa , Lu Genliang , Zhang Yongmin
Published: June 2021

Unsymmetrical α-amino sulfides are synthesized in moderate to good yields via the reactions of 1-(α-aminoalkyl)benzotriazoles with sodium alkylthiosulfates promoted by the Sm/ZnCl2 system in THF–water.
The Chemistry of the Hydrazine–Hydroxylamine–Nitric Acid System at High Temperatures
Authors: Bourke Gerard C. M. , Stedman Geoffrey
Published: June 2021

The kinetics of decomposition of hydrazine and hydroxylamine in concentrated nitric acid at 70 °C establish a critical concentration [hydrazine] ≍ 5 × 10−4 mol dm−3 below which a rapid autocalalytic decomposition of hydroxylamine occurs; this corresponds to the rate of nitrite scavenging by hydrazine balancing the rate of N2O4 formation.
Synthesis of Substituted Glycerol Selenide Ethers under Microwave Irradiation
Authors: Wang Jin-Xian , Wu Xiaowei , Hu Yulai , Zhao Kai , Liu Zhanxiang
Published: June 2021

Substituted glycerol selenide ethers are rapidly obtained in high yields and good regioselectivities by reducing dialkyl diselenides with sodium tetrahydroborate in a basic environment followed by reaction with glycidyl sulfide ether under microwave irradiation conditions.
The Epoxidation of Androstane and Pregnane 2,4-Dienes
Authors: Hanson James R. , Kiran Ismail
Published: June 2021

The epoxidation of 6β-acetoxyandrosta-2,4-diene-17-one, 6β-acetoxypregna-2,4-diene-20-one and the corresponding 6-ketones with m-chloroperbenzoic acid is shown to give, unexpectedly, the 4α,5α-monoepoxides.
New Routes for Novel Pyrazolo[3,4-b][1,6]-naphthyridine, Pyrazolo[3,4-b]pyridine and Pyrazolo[3,4:2,3]pyrido[6,1-a]benzimidazole Derivatives
Authors: Abd El Latif Fawi M. , Barsy Magda A. , Elrady Eman A. , Hassan M.
Published: June 2021

Pyrazolo[3,4- b] [1,6] naphthyridine, pyrazolo[3,4- b] pyridine and pyrazolo[3,4:2,3] pyrido [6,1 -a] benzimidazole derivatives are synthesized starting from the isomeric 3-substituted 5-chloro-1-phenylpyrazole-4-carbaldehyde.
Steroidal Aphidicolin Analogues Derived from Pregnenolone
Authors: Hanson James R. , Yildirim Kudret
Published: June 2021

The conversion of pregnenolone into the 3β,5α-, 3α,5α-, 4β,5α-, 3α,4α-, 3α,4β- and 3α,4α-dihydroxy derivatives of 17β-hydroxymethyl-5β-androstane as steroidal analogues of the diterpenoid DNA polymerase α inhibitor, aphidicolin, is described.
Synthesis and Visible Spectral Behaviour of Some New Photosensitizers: Monomethine, Dimethine, Trimethine, Styryl and Mixed Cyanine Dyes
Authors: Shindy Hassan A.
Published: June 2021

The new photosensitizers, monomethine, dimethine, trimethine, styryl and mixed cyanine dyes incorporating pyrazolo/oxazole(thiazole) nuclei are prepared; the visible absorption spectra for all the synthesized cyanines were examined in 95% ethanol; structural confirmation is carried out by elemental analysis, IR and 1H NMR spectroscopy.