bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Anti-SARS-CoV-2 IgA Response in Tears of Vaccinated COVID-19 Subjects
Authors: Soffritti Irene , D’Accolti Maria , Gallenga Carla , De Giorgio Roberto , Guarino Matteo , Maritati Martina , Bini Francesca , Mazziga Eleonora , Contini Carlo , Caselli Elisabetta
Published: January 2023

Secretory IgA (sIgA), which may play an important role in the early defense against SARS-CoV-2 infection, were detected in the eye of COVID-19 patients. However, an evaluation of the sIgA response in the tears of vaccinated or non-vaccinated COVID-19 subjects is still lacking. Aimed at characterizing sIgA mucosal immunity in the eye, this study analyzed tear samples from 77 COVID-19 patients, including 63 vaccinated and 14 non-vaccinated subjects. The groups showed similar epidemiological features, but as expected, differences were observed in the percentage of asymptomatic/pauci-symptomatic subjects in the vaccinated vs. non-vaccinated cohort (46% and 29% of the total, respectively). Consistent with this, ocular sIgA values, evaluated by a specific quantitative ELISA assay, were remarkably different in vaccinated vs. non-vaccinated group for both frequency (69.8% vs. 57.1%, respectively) and titer (1372.3 U/mL vs. 143.7 U/mL, respectively; p = 0.01), which was significantly differently elevated depending on the type of administered vaccine. The data show for the first time significant differences of available vaccines to elicit sIgA response in the eye and suggest that quantitative tear-based sIgA tests may potentially serve as a rapid and easily accessible biomarker for the assessment of the development of a protective mucosal immunity toward SARS-CoV-2.
Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines
Authors: Szeto Jason , Beharry Aruun , Chen Tricia , Zholumbetov Eric , Daigneault Emilie , Ming Marin , Lounsbury Iain , Eng Nelson , Thangavadivel Nemika , Jin Robbie , Denis-Jacquot Aurélie , Azad Bahram Behnam , Li Meili , Keizner Diana , Liu Marcus , Lee Sophia S. F. , He Kai , Gajewska Beata
Published: January 2023

There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present ethical concerns. The development of relevant in vitro assays is part of the solution. Using pertactin (PRN) antigen as an example in DTaP-IPV (diphtheria, tetanus, acellular pertussis, and inactivated poliovirus) vaccines, a PRN antigenicity ELISA was developed using two monoclonal antibodies with a high affinity to unique PRN epitopes, relevance to human immune responses, and evidence of functionality. The ELISA measured consistent PRN antigenicity between the vaccine lots and was validated to demonstrate its accuracy, precision, linearity, and specificity. Notably, the PRN antigenicity ELISA was more sensitive than the mouse-based potency test and could more effectively differentiate between degraded and intact vaccine lots compared to the in vivo test. From these studies, the PRN antigenicity ELISA is proposed as an in vitro replacement for the in vivo potency test for PRN in DTaP-IPV-based formulations. Important considerations in this study included comprehensive antibody characterization, testing of multiple vaccine lots, method validation, and comparison to animal-based potency. Together, these factors form part of an overall strategy that ensures reliable and relevant in vitro assays are developed to replace animal tests.
The Influence of Booster Shot and SARS-CoV-2 Infection on the Anti-Spike Antibody Concentration One Year after the First COVID-19 Vaccine Dose Administration
Authors: Swadźba Jakub , Anyszek Tomasz , Panek Andrzej , Chojęta Agnieszka , Piotrowska-Mietelska Anna , Martin Emilia
Published: January 2023

This study pictures the humoral response of 100 vaccinees to Pfizer/BioNTech COVID-19 vaccine over a year, with particular focus on the influence of a booster shot administered around 10 months after the primary immunization. The response to the vaccination was assessed with Diasorin’s SARS-CoV-2 TrimericSpike IgG. Abbott’s SARS-CoV-2 Nucleocapsid IgG immunoassay was used to identify SARS-CoV-2 contact, even asymptomatic. In contrast to the gradual decline of the anti-spike IgG between 30 and 240 days after the first dose, an increase was noted between days 240 and 360 in the whole cohort. However, a statistically significant rise was seen only in boosted individuals, and this effect of the booster decreased over time. An increase was also observed in non-boosted but recently infected participants and a decrease was reported in non-boosted, non-infected subjects. These changes were not statistically significant. On day 360, a percentage of new SARS-CoV-2 infections was statistically lower in the boosted vs. non-boosted subgroups. The booster immunization is the most efficient way of stimulating production of anti-spike, potentially neutralizing antibodies. The response is additionally enhanced by the natural contact with the virus. Individuals with a low level of anti-spike antibodies may benefit the most from the booster dose administration.
Immunogenicity and SARS-CoV-2 Infection following the Fourth BNT162b2 Booster Dose among Health Care Workers
Authors: Shachor-Meyouhas Yael , Dabaja-Younis Halima , Magid Avi , Leiba Ronit , Szwarcwort-Cohen Moran , Almog Ronit , Mekel Michal , Weissman Avi , Hyams Gila , Gepstein Vardit , Horowitz Nethanel A. , Cohen Saban Hagar , Tarabeia Jalal , Halberthal Michael , Hussein Khetam
Published: January 2023

Introduction: The fourth SARS-CoV-2 vaccine dose was found to protect against infection and more importantly against severe disease and death. It was also shown that the risk of symptomatic or severe disease was related to the antibody levels after vaccination or infection, with lower protection against the BA.4 BA.5 Omicron variants. The aim of our study was to assess the impact of the fourth dose on infection and perception of illness seriousness among healthcare workers (HCWs) at a tertiary health care campus in Haifa, Israel, and to investigate the possible protective effect of antibody levels against infection. Methods: We conducted a prospective cohort study among fully vaccinated HCWs and retired employees at Rambam Healthcare Campus (RHCC), a tertiary hospital in northern Israel. Participants underwent serial serological tests at 1, 3, 6, 9, 12 and 18 months following the second BNT162b2 vaccine dose. Only a part of the participants chose to receive the fourth vaccine. A multivariable logistic regression was conducted to test the adjusted association between vaccination, and the risk of infection with SARS-CoV-2. Kaplan–Meier SARS-CoV-2 free “survival” analysis was conducted to compare the waning effect of the first and second, third and fourth vaccines. Receiver Operating Characteristic (ROC) curve was plotted for different values of the sixth serology to identify workers at risk for disease. Results: Disease occurrence was more frequent among females, people age 40-50 years old and those with background chronic lung disease. The fourth vaccine was found to have better protection against infection, compared to the third vaccine; however, it also had a faster waning immunity compared to the third vaccine dose. Antibody titer of 955 AU/mL was found as a cutoff protecting from infection. Conclusions: We found that the fourth vaccine dose had a protective effect, but shorter than the third vaccine dose. Cutoff point of 955 AU/mL was recognized for protection from illness. The decision to vaccinate the population with a booster dose should consider other factors, including the spread of disease at the point, chronic comorbidities and age, especially during shortage of vaccine supply.
Perceived Barriers and Intentions to Receive COVID-19 Vaccines: Psychological Distress as a Moderator
Authors: Nga Ngo Thi Viet , Xuan Vu Ngoc , Trong Vu Anh , Thao Pham Huong , Doanh Duong Cong
Published: January 2023

A high vaccination uptake degree is crucial to achieve herd immunity to COVID-19 and restrict the spread of the COVID-19 pandemic. However, little is known about the antecedents that reduce or contribute to shaping the intention to receive COVID-19 vaccines, as well as how psychological distress—a mental health problem—can reinforce or dampen the translation from antecedents into intention to receive COVID-19 vaccines. The objective of this study was to explore the effects of perceived clinical and access barriers, self-efficacy, and attitudes towards COVID-19 vaccines on the intention to receive COVID-19 vaccines. Simultaneously, the moderation effects of psychological distress on this relationship were also examined. Using a sample of 2722 Vietnamese adults and structural equation modeling (SEM), this study illustrated that self-efficacy and attitudes towards COVID-19 vaccines were significantly interrelated with intention to receive COVID-19 vaccines. Self-efficacy, attitudes towards COVID-19 vaccines, and intention to receive COVID-19 vaccines were negatively influenced by perceived access barriers but were positively associated with perceived clinical barriers. Importantly, our study reported that when psychological distress was higher, the link between self-efficacy and intention to receive COVID-19 vaccines will become weaker, but the effect of perceived clinical barriers on intention to receive COVID-19 vaccines will be reinforced. Moreover, self-efficacy and attitudes towards COVID-19 vaccines served as mediators in the linkages between perceived barriers and intention to receive COVID-19 vaccines. Besides providing contributions to the extant COVID-19 vaccine literature, this study provides useful recommendations for practitioners and policymakers to foster adults’ COVID-19 vaccine acceptance.
Prevalence and Motivators of Getting a COVID-19 Booster Vaccine in Canada: Results from the iCARE Study
Authors: Léger Camille , Deslauriers Frédérique , Gosselin Boucher Vincent , Phillips Meghane , Bacon Simon L. , Lavoie Kim L.
Published: January 2023

Studies have shown that the protection afforded by COVID-19 vaccines against hospitalization and death decreases slowly over time due to the emergence of new variants and waning immunity. Accordingly, booster doses remain critical to minimizing the health impacts of the pandemic. This study examined the prevalence rate, sociodemographic determinants, and motivators of getting a COVID-19 booster vaccine within the Canadian population. We recruited a representative sample of 3001 Canadians aged 18+ years as part of the iCARE study using an online polling form between 20 January and 2 February 2022. Participants self-reported their booster status and were dichotomized into two groups: those who did vs. did not receive at least one booster dose. A total of 67% of participants received a booster dose. Chi-square analyses revealed that older age (p < 0.001) and having a chronic disease diagnosis (p < 0.001) were associated with being more likely to get a booster. Boosted individuals reported motivators tied to efficacy and altruism, whereas non-boosted individuals reported motivators tied to efficacy and safety. Results suggest that messaging will require careful tailoring to address the identified behavioral motivators among non-boosted individuals who emphasize safety and efficacy of additional vaccine doses.
The Development of Surface-Modified Liposomes as an Intranasal Delivery System for Group A Streptococcus Vaccines
Authors: Yang Jieru , Boer Jennifer C. , Khongkow Mattaka , Phunpee Sarunya , Khalil Zeinab G. , Bashiri Sahra , Deceneux Cyril , Goodchild Georgia , Hussein Waleed M. , Capon Robert J. , Ruktanonchai Uracha , Plebanski Magdalena , Toth Istvan , Skwarczynski Mariusz
Published: January 2023

Intranasal vaccine administration can overcome the disadvantages of injectable vaccines and present greater efficiency for mass immunization. However, the development of intranasal vaccines is challenged by poor mucosal immunogenicity of antigens and the limited availability of mucosal adjuvants. Here, we examined a number of self-adjuvanting liposomal systems for intranasal delivery of lipopeptide vaccine against group A Streptococcus (GAS). Among them, two liposome formulations bearing lipidated cell-penetrating peptide KALA and a new lipidated chitosan derivative (oleoyl-quaternized chitosan, OTMC) stimulated high systemic antibody titers in outbred mice. The antibodies were fully functional and were able to kill GAS bacteria. Importantly, OTMC was far more effective at stimulating antibody production than the classical immune-stimulating trimethyl chitosan formulation. In a simple physical mixture, OTMC also enhanced the immune responses of the tested vaccine, without the need for a liposome delivery system. The adjuvanting capacity of OTMC was further confirmed by its ability to stimulate cytokine production by dendritic cells. Thus, we discovered a new immune stimulant with promising properties for mucosal vaccine development.
Water Harvesting in the Garmian Region (Kurdistan, Iraq) Using GIS and Remote Sensing
Authors: Aziz Shvan F. , Abdulrahman Kawa Z. , Ali Salahaldin S. , Karakouzian Moses
Published: January 2023

Rainwater harvesting (RWH) is one of the essential alternative sources of water that may be used. However, finding potential RWH locations on a broad scale has always been challenging, requiring further research. The effectiveness of RWH structures depends on their design and the selection of suitable sites. This study aimed to select potential sites for rainwater harvesting in the Garmian region of Kurdistan-Iraq, using GIS and Remote Sensing (RS) techniques. Two multicriteria analysis (MCA) techniques: the analytical hierarchal process (AHP) and Fuzzy analytical hierarchal process (FAHP) were used for comparison purposes to identify potential RWH sites. A suitability map of potential RWH systems was then generated following the weighted linear combination (WLC) and the Fuzzy Gamma methods. The outcomes showed that, unlike most recent studies, which relied on the minimum and maximum local rainfall values, a minimum agreed-upon rainfall depth should be used as a benchmark when classifying rainfall to obtain realistic results. The findings also showed that 9.7%, 43.4%, 33.6%, and 13.3% of the sites have very high, high, moderate, and low suitability for rainwater harvesting, respectively, depending on the suitability map produced by the WLC method. However, the outcome of the Fuzzy Gamma technique appeared more realistic and revealed that 10.6%, 15.6%, 26.6%, 21.9%, and 25.3% of the sites have very high, high, moderate, low, and very low appropriateness for rainwater harvesting, respectively. The methods adopted in this study can be helpful for researchers in the field of RWH to achieve reliable results. Also, this study’s findings can assist in well-organized water resource management planning to ensure sustainable water development in the Garmian region.
Stream Slope as an Indicator for Drowning Potential at Low Head Dams
Authors: Poff Jason W. , Hotchkiss Rollin H.
Published: January 2023

With the increasing availability of low head dam inventories for the United States, the next challenge is discovering how to determine what dams pose the greatest risk to public safety, preferably before a death occurs. Submerged hydraulic jumps create the dangerous current that drowns roughly 50 recreationists each year, and high tailwater is a key element in its formation. Using a simplified approach based on the Manning equation, flat downstream slopes can be a predictor of high tailwater. Stream slopes at low head dams in Colorado, Idaho, Indiana, Maryland, New Mexico, North Carolina, and Pennsylvania were collected from the NHDPlus HR, and dams with recorded fatalities were compared to stream slopes at low head dams with no recorded fatalities. Using the Mann–Whitney U test, there was not enough evidence to reject the null hypothesis that there is no statistically significant difference between the two populations. Until more fatality data are compiled and more low head dam locations are verified, individual testing of dams is recommended to establish each respective flow range that is likely to pose a risk to public safety.
Removal of Chromium Species from Low-Contaminated Raw Water by Different Drinking Water Treatment Processes
Authors: Konradt Norbert , Dillmann Saskia , Becker Jennifer , Schroden Detlef , Rohns Hans-Peter , Wagner Christoph , Müller Uwe , Konradt Daniel , Janknecht Peter , Hobby Ralph , ElSherbiny Ibrahim M. A. , Panglisch Stefan
Published: January 2023

The occurrence of Cr (VI) in drinking water resources in low but toxicologically relevant concentrations requires the development of reliable and industrially applicable separation processes in drinking water treatment. There is little information in the literature on the removal of chromium species at concentrations below 10 µg/L. Therefore, in this study, the removal of chromium in the concentration range ≤10 µg/L was investigated using three separation processes, activated carbon filtration (ACF), reduction/coagulation/filtration (RCF) and low-pressure reverse osmosis (LPRO), in both laboratory- and pilot-scale tests. In ACF treatment, Cr (III) was removed by deep bed filtration over 1.5 m of anthracite at a pH of 7.5 (which was used as a prefilter prior to ACF), while Cr (VI) was removed up to 75% via ACF at a filter bed depth of 2.5 m. Fresh activated carbon (AC) exhibited the highest adsorption capacity for Cr (VI), while reactivated AC had a significantly lower capacity for Cr (VI), which was attributed to calcium and iron deposits. In technical filters, where multiple reactivated activated carbon is used, this led to a low removal rate for Cr (VI). Using the RCF process with Fe (II) dosing in a continuous flow reactor at a specific coagulant dosing ratio, high Cr (VI) removal, down to a concentration of 0.1 µg/L, was achieved within minutes. The subsequent anthracite filtration ensured the complete removal of Fe (III) and Cr (III) precipitates. The RCF process was limited by the oxygen side reaction with Fe (II), which dominated at Cr (VI) concentrations below 1 µg/L. In addition, a four-step LPRO process with concentrate recycling showed effective removal (>99%) of both Cr (III) and Cr (VI) species in raw water as well as a negligible effect of pH in the testing pH range of 5.6 to 8.3 on the Cr (VI) removal. Nevertheless, the water hardness and pH of the LPRO permeate must be increased to make it available as drinking water. The three separation processes were found to be able to meet the expected more stringent future regulations for Cr (VI) level in drinking water. The most suitable technology, however, can be selected with respect to the raw water quality/characteristics, site-specific conditions and the already existing equipment.
Appraisal of Groundwater Vulnerability Pollution Mapping Using GIS Based GOD Index in Tiruchendur, Thoothukudi District, India
Authors: Sekar Selvam , Kamaraj Jesuraja , Poovalingam Sivasubramanian , Duraisamy Radhika , Senapathi Venkatramanan , Sang Yong Chung
Published: January 2023

Recently, groundwater resources have become the main freshwater supply for human activities worldwide, especially in semi-arid regions, and groundwater pollution from anthropological events is one of the chief environmental problems in built-up and industrial coastal areas. Many researchers around the world have conducted studies to evaluate the impact of groundwater management. For this study, GIS based GOD vulnerability models were used to assess the intrinsic impact and risk of pollution of coastal and irrigated areas in Tiruchendur Taluk, Thoothukudi district in Tamil Nadu. Here, GOD stands for G—Groundwater hydraulic confinement, O—Overlying aquifer strata, and D—Depth to groundwater. The parameters of G, O, and D show that 70% of the study area consists of an unconfined aquifer whose central part often consists of sandstone and fine to medium clay with sand along the coast that acts as an aquifer. The recorded value was 1–28 mbgl. The map of vulnerability using the GOD method shows that 32% of the medium vulnerabilities are located in the almost northern part of the study area, where the main source of pollution is from agricultural land and anthropological activities. A total of 39 groundwater samples were collected from different types of aquifers and used to validate the pollution map, using the EC concentration (230 to 15,480 µs/cm with an average of 2758 µs/cm) and NO3− concentration (2 to 120 mg/L with an average of 46 mg/L) in groundwater as indicators of pollution. Finally, we measured how the EC and NO3− parameters represent the medium vulnerability zone of the GOD model based on the pattern of their concentrations in groundwater. Therefore, the GIS with GOD model is the best model among these models for predicting groundwater vulnerability in Tiruchendur Taluk.
Preparation of Sulfhydryl Functionalized MCM-48 and Its Adsorption Performance for Cr(VI) in Water
Authors: Li Heng , Wang Shijing , Li Ranran , Zhang Yan , Wang Hao
Published: January 2023

In this study, we modify the Mobil Composition of Matter No. 48 (MCM-48) silica material (MCM-48-SH) using Mercapto. The preparation conditions of MCM-48-SH are then explored, its structural characteristics are analyzed using characterization, and it is used to adsorb Cr(VI) from wastewater. A series of experiments are then designed to adsorb Cr(VI) in experimental water, and the influence of solution environment changes (such as time, temperature, pH, and coexisting ions) on the adsorption effect was explored. The experimental data showed that the MCM-48-SH material not only retained the basic structure of MCM-48 but also successfully grafted the functional group -SH. The adsorption of Cr(VI) on MCM-48-SH followed the Langmuir isotherm model and the kinetic adsorption was fitted with a pseudo-second-order kinetic model. Under these conditions, the adsorption capacity of MCM-48-SH (17.9 mg/g) on Cr(VI) was much larger than that of unmodified MCM-48 (4.0 mg/g) and amino-modified MCM-48-NH2 (0.5 mg/g). The adsorption effect was the most obvious when the pH = 2 but the adsorption effect was not good under alkaline conditions. Other competitive ions in the solution had an influence on the adsorption effect, among which anions had a great influence. Within 3 d, when the concentration of Cr(VI) was 80 mg/L, the maximum adsorption capacity reached 17.9 mg/g and the maximum removal rate reached 93.45%. In the comparative adsorption experiment, the adsorption effect of MCM-48-SH (17.9 mg/g) on Cr(VI) was notably better than that of the other two common adsorbents: coconut shell activated carbon (9.2 mg/g) and bentonite (1.2 mg/g). In summary, MCM-48-SH can be used to effectively eliminate Cr(VI) in waste water.
Radial Oxygen Loss of Three Plants under Hydroponic Culture and Its Relationships with Pollution Removal
Authors: Wei Yulu , Li Chaokun , Han Liu , Xi Hui , Tian Yinqiang , Yeo Kanfolo Franck Hervé , Wang Wendong
Published: January 2023

The growth status, root exudates, radial oxygen loss, and sewage purification effect of plants acclimated with sewage and cultured with a nutrient solution were studied by selecting Acorus gramineus Aiton, Pistia stratiotes L., and Eichhornia crassipes (Mart.) Solms with the same individual size. The results showed that the root oxygen secretion rate of the Acorus gramineus Aiton was higher in light and dark conditions. For a single plant species, the oxygen secretion rate under light conditions was much higher than that under dark conditions. The root oxygen secretion rate of Acorus gramineus Aiton was the highest (2.03 µmol O2/h/plant), followed by Pistia stratiotes L. (1.68 µmol O2/h/plant), and the root oxygen secretion rate of Eichhornia crassipes (Mart.) Solms was the lowest (1.15 µmol O2/h/plant). After a period of adaptation, plants showed strong removal effects on COD, NH3-N, TN, and TP. The removal intensity was in the order of Acorus gramineus Aiton > Pistia stratiotes L. > Eichhornia crassipes (Mart.) Solms; the higher the temperature, the bigger the removal rate. These results were consistent with Acorus gramineus Aiton‘s organic matter secretion and radial oxygen loss, which were better than those of Pistia stratiotes L. and Eichhornia crassipes (Mart.) Solms. Three kinds of plants had better COD removal effects in an acidic environment and better TP removal effects in an alkaline environment. The results show that using the Acorus gramineus Aiton can achieve better remediation of polluted water bodies.
Effect of Potassium Dihydrogen Phosphate Combined with Thermally Activated Nano Serpentine and Thermally Activated Nano Zeolite on Cadmium in Soil
Authors: Wang Xiuli , Liu Hongdou , Zou Hongtao
Published: January 2023

The combined application of potassium dihydrogen phosphate (KH2PO4) and thermally activated nano serpentine and KH2PO4 and thermally activated nano zeolite could immobilize cadmium (Cd) in contaminated soils by increasing soil pH value. The results showed that adding nPS700-2.0 (KH2PO4 and thermally activated nano serpentine activated at 700 °C, 2% addition) exhibited better performance under the same treatment condition; it reduced DTPA-Cd by 57.8% and exchangeable Cd by 48.76%. Adding nPF700 (KH2PO4 and thermally activated nano zeolite activated at 700 °C) reduced DTPA-Cd by 35.49–44.17% and exchangeable Cd by 35.89–42.57%, respectively. The increase of active adsorption points and the surface area of thermally activated nano serpentine reduced the bioavailability of Cd in soil, indicating that the combined application of phosphate and thermally activated nano serpentine has great potential for the immobilization of Cd in soil.
Hydrodynamic Decontamination of Groundwater and Soils Using ZVI
Authors: Antia David D. J.
Published: January 2023

Polluted aquifers can be decontaminated using either ZVI (zero valent iron) permeable reactive barriers (PRB) or injected ZVI. The placement of ZVI within the aquifer may take several decades to remediate the contaminant plume. Remediation is further complicated by ZVI acting as an adsorbent to remove some pollutants, while for other pollutants, it acts as a remediation catalyst. This study investigates an alternative aquifer decontamination approach to PRB construction or n-Fe0 injection. The alternative approach reconstructs the potentiometric surface of the aquifer containing the contaminant. This reconstruction confines the contaminant plume to a stationary, doughnut shaped hydrodynamic mound. Contaminated water from the mound is abstracted, decontaminated, and then reinjected, until all the water confined within the mound is decontaminated. At this point, the decontaminated mound is allowed to dissipate into the surrounding aquifer. This approach is evaluated for potential use in treating the following: (i) immiscible liquid plumes; (ii) miscible contaminant and ionic solute plumes; (iii) naturally contaminated aquifers and soils; and (iv) contaminated or salinized soils. The results indicate that this approach, when compared with the PRB or injection approach, may accelerate the decontamination, while reducing the overall amount of ZVI required.
Study on Suitable Rice Planting Scale Based on Balance of Groundwater Recharge and Discharge in Sanjiang Plain
Authors: Guo Hui , Sun Qingyan , Wu Zhenjiang , Lu Chuiyu , Qin Zidong
Published: January 2023

In addition to implementing active water resource allocation measures to solve the serious groundwater overexploitation problem caused by large-scale rice planting in the Sanjiang Plain, the reasonable adjustment of rice planting areas is another method of doing so. From the perspective of groundwater recharge and discharge balance, this paper carries out a novel assessment of suitable rice planting areas in the Sanjiang Plain, which is expected to provide a new method for the implementation of land exploitation according to water resource conditions. The technical scheme is as follows: by adjusting the water resource allocation data and rice spatial distribution data in the surface water–groundwater coupled model (baseline model with dynamic land use) in the Sanjiang Plain, static land-use models under different rice planting scales were established. Through simulation and comparison, the rice area that could achieve the balance of groundwater recharge and discharge was considered the suitable rice planting scale in the Sanjiang Plain. The results showed that the average annual change in groundwater storage from 2000 to 2014 simulated by the baseline model was −0.313 billion m3, indicating that there was space for further optimization and adjustment of the rice planting scale in the Sanjiang Plain. By comparing the static land-use models of each year under the current water resource allocation pattern, the rice area of 1.021 million hm2 in 2005 could effectively realize the balance of groundwater recharge and discharge. Under the new water resource allocation pattern of 2035, the water resource conditions in the Sanjiang Plain will be greatly improved, which can support a rice planting scale of 3.058 million hm2 on the basis of ensuring the balance of groundwater recharge and discharge. Our research results can provide a reference for water resource allocation and land-use optimization regulation in the Sanjiang Plain.
Hazards in Seafood Notified in the Rapid Alert System for Food and Feed (RASFF) in 1996–2020
Authors: Pigłowski Marcin
Published: January 2023

Seafood covering fish, crustaceans, molluscs and cephalopods is broadly recognised for its nutritional value and popularity, but it can pose some hazards to health to the potential consumer. The aim of the study was to analyse Rapid Alert System for Food and Feed (RASFF) notifications for seafood over the period 1996–2020 by hazard, year, product, notifying country, country of origin, notification type, notification basis, distribution status and action taken. The research applied cluster analysis using the joining and two-way joining methods. The main reported hazards were micro-organisms (Listeria, Salmonella, Escherichia coli, Vibrio, norovirus, mesophiles, Enterobacteriaceae and histamine), heavy metals (mercury and cadmium), veterinary products (nitrofuran, chloramphenicol and leucomalachite green), controls (poor temperature control and hygienic state), parasites (Anisakis) and additives/allergens (sulphite). The reported seafood products originated mainly from European and Asian countries and were notified on the basis of official or border controls, respectively. In order to minimize or eliminate risks, it is important to have the right activity of control authorities, appropriate legislation at the European and national levels and awareness at the different stages of the food chain.
Dijital Öykü Çalışmalarının Dil Becerilerine Yansımaları
Authors: DEMİRKOL Sarenur , GİRMEN Pınar
Published: January 2023

Bu çalışmanın amacı, dijital öykü çalışmalarının dil becerilerine yansımalarını ortaya koymaktır. Araştırmada, temel nitel araştırma yaklaşımından yararlanılmıştır. Araştırmanın çalışma grubunu, 2005-2021 yılları arasında yapılmış, bulguları arasında temel dil becerilerine katkısı bulunan dijital öykü çalışmaları ve yurt içinde sınıf eğitimi alanında, dijital öykü konusunda lisansüstü tez yazmış 7 araştırmacı oluşturmaktadır. Araştırmanın verileri, doküman incelemesi ve yarı yapılandırılmış görüşmeler aracılığıyla elde edilmiştir. Verilerin çözümlemesinde, betimsel analizden yararlanılmıştır. Gerçekleştirilen analizler sonucunda araştırma bulguları Dinleme, Konuşma, Okuma ve Yazma Becerisi olarak 4 ana tema etrafında toplanmıştır. Araştırmacılarla yapılan görüşmeler sonunda, dijital öykü çalışması yapacak araştırmacılar için ön hazırlık çalışmasının yapılması gerektiği, teknolojik okuryazarlığın ve teknolojik altyapının önemli olduğu belirlenmiştir. Araştırmanın sonunda, dijital öykü etkinliklerinin dinleme, okuduğunu anlama ve yazma stratejilerini, konuşma motivasyonunu olumlu yönde desteklediği sonucuna ulaşılmıştır.
2018-2021 LGS Fen Sorularının Bloom Taksonomisine Göre İncelenmesi
Authors: OĞUZTEKİN Eda , BEKTAS Oktay
Published: January 2023

Bu araştırmada 2018-2021 LGS fen sorularının Bloom taksonomisine göre incelenmesi amaçlanmıştır. Bu kapsamda belirtilen yıllarda LGS sınavında yer alan toplam 80 fen bilimleri sorusu incelenmiştir. Çalışma nitel araştırma desenlerinden durum çalışmasına göre yapılandırılmış olup veri toplama aracı olarak doküman incelemesinden yararlanılmıştır. Veriler ise betimsel analizine göre analiz edilmiştir. Çalışma sonucunda elde edilen bulgular frekans ve yüzde şeklinde sunulmuştur. İnceleme sonucunda yıllara göre soruların en çok analiz basamağında (%61,25) yer aldığı belirlenmiştir. Daha sonra sırasıyla kavrama (%18,75), değerlendirme (%11,25) ve uygulama (%8,75) basamaklarından soruların yer aldığı sonucuna ulaşılmıştır. Sınavda bilgi basamağından hiçbir sene soru sorulmaması dikkat çeken bir diğer sonuç olmuştur. Araştırmadan elde edilen sonuçlar ışığında, taksonomik açısından soruların bütün basamaklara hitap edebilecek düzeyde ve dengeli bir şekilde dağıtılması gerektiği öneri sunulmuştur.
Türkiye’de Sosyal Bilgiler Eğitiminde Müze Eğitimi ile İlgili Yapılan Araştırmalara Yönelik Bir Meta-Sentez Çalışması
Authors: SAĞLAMGÖNCÜ Ahmet
Published: January 2023

Müzeler, sosyal bilgiler dersinde yararlanılabilecek okul dışı öğrenme ortamlarından biridir. Sosyal bilgiler dersinde okul dışı öğrenme kapsamında müzelerden etkili bir biçimde yararlanmak için bu konuda yapılan bilimsel çalışmalar ilgili alanyazına önemli katkılar sağlamaktadır. Sosyal bilgiler eğitiminde müze eğitimi ile ilgili çalışmaların incelenmesi bu çalışmalardan elde edilen sonuçlardan daha etkili bir biçimde yararlanmayı sağlayacaktır. Bu araştırmada Türkiye’de sosyal bilgiler eğitiminde müze eğitimine yönelik yapılan çalışmaların meta-sentez yöntemiyle değerlendirilmesi amaçlanmıştır. Araştırmada 2010-2021 yılları arasında yayımlanan sosyal bilgiler eğitiminde müze eğitimine yönelik nitel bulguları olan iki yüksek lisans tezi ve 17 araştırma makalesi incelenmiştir. İncelenen çalışmalara Yükseköğretim Kurulu (YÖK) Tez Veri Tabanı, TR Dizin, EBSCOhost ve Google Akademik veri tabanlarından ulaşılmıştır. Araştırma kapsamında yer alan her bir çalışma amaç, araştırma deseni, çalışma grubunun seçimi, veri toplama araçları, sonuç ve öneriler başlıkları çerçevesinde analiz edilerek incelenmiştir. Veriler betimsel analiz tekniğiyle çözümlenmiştir. Türkiye’de sosyal bilgiler eğitiminde müze eğitimine yönelik yapılan çalışmalar genel olarak incelendiğinde, çalışmaların katılımcı görüşlerini almaya yönelik olduğu, yöntem kapsamında daha çok olgubilim deseninde yürütüldüğü, çalışmalarda veri toplama aracı olarak en çok görüşme formunun kullanıldığı, araştırmaların çoğunda çalışma gruplarını öğrencilerin ve öğretmen adaylarının oluşturduğu ve çalışma grubu belirleme yöntemine yer verilmediği görülmüştür. İncelenen çalışmalarda sosyal bilgiler eğitiminde müze eğitiminin zorluklarına ve yararlarına ilişkin benzer sonuçlar bulunmaktadır. Yine incelenen çalışmaların öneriler bölümünde sosyal bilgiler eğitiminde müze eğitimine yönelik görev yapan öğretmenlerin eğitimine, öğretmen adayı eğitimine, araştırma konusuna ve müze ile eğitim sürecine ilişkin öneriler sunulmuştur. Araştırma sonuçlarına dayalı olarak, sosyal bilgiler eğitiminde müze eğitimine yönelik uygulamaya dayalı çalışmaların yapılması ve araştırmaların yöntem bölümünde verilen bilgilerin detaylandırılması biçiminde çeşitli öneriler sunulmuştur.
Sınıf Öğretmeni Adaylarının Çocuk Kitaplarına İlişkin Farkındalıkları
Authors: ÇETİNKAYA ÖZDEMİR Ezgi , KAYA ÖZGÜL Bengisu
Published: January 2023

Bu çalışmada, Sınıf Eğitimi Anabilim Dalında seçmeli bir ders olan Çocuk Edebiyatı dersini alan ve almayan sınıf öğretmeni adaylarının çocuk kitaplarına ilişkin farkındalıklarını ortaya koymak amaçlanmıştır. Nitel araştırma desenlerinden biri olan “durum çalışması” yaklaşımı benimsenen çalışmanın katılımcıları, iki farklı devlet üniversitesinin Eğitim Fakültelerinde Sınıf Eğitimi Anabilim Dalında 2. sınıfta öğrenimlerine devam eden toplam 113 öğretmen adayıdır. Çalışmada veri toplama aracı olarak araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu kullanılmıştır. Veriler 2020 yılı ocak ayından önce toplandığı için etik kurul izni bulunmamaktadır. Verilerin analizinde, nitel veri analiz tekniklerinden içerik analizi kullanılmıştır. Araştırma bulguları incelendiğinde, Çocuk Edebiyatı dersi alan sınıf öğretmeni adaylarının; çocuk kitaplarının eğitsel olarak taşıması gereken özellikler, kitap önerisinde bulunurken göz önüne alınacak nitelikler, kitapların taşıması gereken biçimsel ve içerik özellikleri ile ilgili iyi düzeyde bir farkındalığa sahip oldukları tespit edilmiştir. Dersi almayan sınıf öğretmeni adaylarının söz konusu kriterler bakımından farkındalık düzeylerinin ise beklenenin üzerinde olduğu görülmüştür. Bu noktada okumayı sevme ve okuma alışkanlığı kazanmada büyük rol oynayan çocuk kitaplarının seçilmesinde ve çocuklara önerilmesinde, anne-babalara ve özellikle öğretmenlere önemli sorumluluklar düşmektedir. Bu nedenle gerek öğretmenlerin gerekse öğretmen adaylarının nitelikli çocuk kitaplarının taşıması gereken özellikleri bilmesi ve öğrencilere kitap önerebilecek seviyede bir farkındalığa sahip olması oldukça önem taşımaktadır. Bununla birlikte Çocuk Edebiyatı dersinin seçmeli ders yerine zorunlu ders olarak programda yer alması önerilmektedir.
Ascorbic Acid Enhances the Metabolic Activity, Growth and Collagen Production of Human Dermal Fibroblasts Growing in Three-dimensional (3D) Culture
Authors: DİKİCİ Serkan
Published: January 2023

Tissue engineering (TE) enables the development of functional synthetic substitutes to be replaced with damaged tissues and organs instead of the use of auto or allografts. A wide range of biomaterials is currently in use as TE scaffolds. Among these materials, naturally sourced ones are favorable due to being highly biocompatible and supporting cell growth and function, whereas synthetic ones are advantageous because of the high tunability on mechanical and physical properties as well as being easy to process. Alongside the advantages of synthetic polymers, they mostly show hydrophobic behavior that limits biomaterial-cell interaction and, consequently, the functioning of the developed TE constructs. In this study, we assessed the impact of L-Ascorbic acid 2-phosphate (AA2P) on improving the culture conditions of human dermal fibroblasts (HDFs) growing on a three-dimensional (3D) scaffold made of polycaprolactone (PCL) using emulsion templating. Our results demonstrated that AA2P enhances the metabolic activity and growth of HDFs as well as collagen deposition by them when supplemented in their growth medium at 50 µg/mL concentration. It showed a great potential to be used as a growth medium supplement to circumvent the disadvantages of culturing human cells on a synthetic biomaterial that is not favored in default. AA2P's potential to improve cell growth and collagen deposition may prove an effective way to culture human cells on 3D PCL PolyHIPE scaffolds for various TE applications.
THE NEED TO INTRODUCE DIGITAL PASSPORTS FOR INDUSTRIAL ENTERPRISES
Authors: Slesarenko G.V.
Published: January 2023

In the modern world, in order to produce competitive products, it is no longer enough to remain at the same level. Modern challenges of the economy involve the introduction of new technologies in the production process, ensuring the introduction of new technological solutions, the process of managing the industrial and human potential of the organization. To this end, the national project «Digital Transformation» is being implemented, the implementation of which is ensured by the Strategy for Digital Transformation of the Manufacturing Industries. As part of this strategy, industrial enterprises create a digital passport, which should ensure the process of monitoring innovation activities, the timely provision of the necessary state support, as well as the exchange of modern advanced technologies for digital transformation. On the GISP information portal, the Ministry of Industry and Trade will monitor and analyze import substitution and the implementation of the best available domestic solutions, assess the level of digitalization and publish information on best practices and advanced solutions. The use of a digital passport will allow enterprises to receive additional funding for the production of new competitive and high-precision products. The need to create a digital passport and a common digitalization system is obvious, however, it will take a lot of time and effort to implement the project. The article provides a rationale for the main aspects of the introduction of modern technologies.
Deposits of Funnel Beaker culture vessels in wells
Authors: Żurkiewicz Danuta
Published: January 2023

This article presents the extraordinary discoveries of ceramic vessel deposits in wells of the Funnel Beaker culture (FBC). Such a custom is observed in all groups of this community but is of particular importance in the Eastern group of the FBC. In central Poland (Kuyavia) specifically, there are many objects of this type compared to older materials of the Linear Pottery culture. The analysis of the local contexts of these finds allows for the hypothesis that the two communities are closely related to be proposed.
Tyčinkové náramky v hrobech únětické kultury v Čechách
Authors: Limburský Petr , Vélová Lucie , Půlpánová-Reszczyńska Agnieszka , Koštová Nikola
Published: January 2023

Při analýze pohřebiště ze starší doby bronzové ve Vliněvsi (střední Čechy, okr. Mělník) byla zkoumána variabilita typů milodarů v hrobech různého pohlaví a věku. Krom jiného se ukázalo téměř výhradní zastoupení tyčinkových náramků v dětských hrobech. Rozborem všech dostupných nálezů tyčinkových náramků v hrobech únětické kultury v Čechách se tato vazba ukázala jako nenáhodná. Autoři diskutují hypotézu o spojení náramků s obdobím nedospělosti a s ním souvisejícími přechodovými rituály, případně ochrannou funkci těchto předmětů.
PENGEMBANGAN LITERASI, NUMERASI, ADAPTASI, TEKNOLOGI, OLEH KAMPUS MENGAJAR ANGKATAN III DI SMP SWASTA HARAPAN BUNUT
Authors: Gurning Maria Rahayu
Published: January 2023

The Independent Learning Campus Independent Program (MBKM) is one of the programs organized by the Ministry of Education and Culture. The Campus Teaching Program is one of the programs in the Merdeka Learning Campus Merdeka Program which aims to teach, assist technology, and assist school administration and teachers. One of the schools targeted for the Teaching Campus program is the Harapan Bunut Private Junior High School which is located in West Bunut, West Kisaran sub-district, Kisaran District, Asahan Regency.The purpose of student participation in the Teaching Campus program is a process of adding relationships, adding experiences outside the world of lectures, developing students' insight, character and soft skills, encouraging and spurring national development by fostering student motivation to participate in development, as well as increasing the role and the real contribution of universities and students in the development of education in Indonesia. The results of this study, students’ motivation tu read increases, and becomes more confident to appear in front of the class. And the level of students’ understanding of numeracy is better than before, both in multiplication, addition, and division. This is in accordance with the achievements containend in the objectives of the Teaching Campus Program.
Magnetic domain control and its dependence on aspect ratio and thickness in Ni nanolayer patterns for nanowire spintronic devices
Authors: Gu Zhe-Rui , Hara Shinjiro
Published: January 2023

We investigate the aspect ratio and thickness dependence of magnetic domain formation in multiple types of ferromagnetic Ni nanolayer electrode patterns. Controlling magnetic domains is critical for spintronic devices using a group IV semiconductor, e.g. Si and Ge, nanowire as the electrodes with magnetic tunnel junction require parallel and anti-parallel magnetization configurations. Single magnetic domains are obtained in the Ni nanolayer electrode patterns on SiO2/Si substrate with an aspect ratio of 20 and a thickness of 40 nm even under the as-deposition condition, while other electrode patterns are mostly showing multiple magnetic domains. The results obtained by magnetic force microscopy also show that the magnetization switching is observed in the electrode pattern with a single magnetic domain. The results in this study show that the suitable design of the dimensions of nanolayer patterns is key to constructing a single magnetic domain in a ferromagnetic electrode for nanowire spintronic devices.
Red emission from InGaN active layer grown on nanoscale InGaN pseudosubstrates
Authors: Cai Wentao , Wang Jia , Park Jeong-Hwan , Furusawa Yuta , Cheong Heajeong , Nitta Shugo , Honda Yoshio , Pristovsek Markus , Amano Hiroshi
Published: January 2023

We demonstrated nanoplatelet In
x
Ga1−x
N pseudosubstrates with In content varying from 0 to 0.3 on low-dislocation-density GaN substrates. These nanoplatelets efficiently relax in-plane strain, thus allowing for the use of a thick active layer to reduce built-in polarization. The 15 nm thick InGaN active layers grown under the same conditions on these nanoplatelets showed a remarkable cathodoluminescence redshift from 460 to 617 nm, suggesting enhanced In incorporation efficiency in InGaN nanoplatelets with higher In content. Moreover, the 617 nm-emitting sample presented an imperceptible blueshift under excitation-power-dependent photoluminescence, indicating a weak polarization field introduced by the high-In-content pseudosubstrates and the thick active layer.
DFT-D3 study of two-dimensional polymerization of C60 crystal under high pressure
Authors: Murata Hidenobu
Published: January 2023

The high-pressure behavior of a monomer and 2D polymerized C60 crystals were investigated using DFT-D3 calculations. Although covalent bonds were not observed in monomer

P
a

3
¯

upon simple compression, C60 moieties in two-dimensional polymer phases (Immm and

R

3
¯

m

phases) exhibited intermolecular electron density, which indicates the formation of covalent bonds between C60 moieties. The C60 crystals were highly compressed under high pressure; however, small compression was observed at the C60 moieties. Both internal energies and PV terms contributed similarly to enthalpy. The deformation of crystals prevented polymerization. These results suggested a different behavior from that of typical inorganic materials.
Gouty Tophus at Unusual Site Presenting As Soft Tissue Mass Diagnosed By Fine Needle Aspiration Cytology with Review of Literature
Authors: Garg Monika , Gupta Malika , Singal Poonam , Nirola Sachin
Published: January 2023

Fine needle aspiration cytology (FNAC) is becoming a popular clinical practice in diagnosis of soft tissue nodules. We present a case of 58 years old male with bilateral, painless sub cutaneous nodules near the elbow without any clinical and radiological features of arthritis. Serum uric acid levels were found to be marginally high. Fine needle aspiration revealed negatively birefringent needle shaped crystals consistent with monosodium urate crystals in amorphous granular debris. Diagnosis of gouty tophi was given. FNAC is a valuable diagnostic tool for the diagnosis of periarticular nodules and pathologists should be aware of cytological features of gouty tophi, particularly in cases of unusual presentation.