bluuebunny/crossref_metadata_2025 huggingface dataset:
The Widowhood Effect: Explaining the Adverse Outcomes After Spousal Loss Using Physiological Stress Theories, Marital Quality, and Attachment
Authors: Ennis Jeffrey , Majid Umair
Published: June 2020

The loss of a loved one is one of the most ubiquitous life experiences. There have been multiple reviews that have found adverse health outcomes for individuals experiencing spousal loss, particularly the widowhood effect that characterizes an increased risk of mortality after loss. However, there is a lack of clarity on the relationship between physiological stress and the widowhood effect. This commentary uses the literature on stress, marital quality, and attachment to explain the widowhood effect and other adverse physical health outcomes. We discuss three points: (1) the chronic nature of stress may be the source of adverse outcomes, (2) the quality and quantity of available resources may moderate the effects of stress, and (3) the level and style of attachment may explain why these outcomes may persist many years after spousal loss.
A Rare Case of Well-Differentiated Neuroendocrine Tumor Arising From a Jejunal Pancreatic Heterotopia
Authors: Sappenfield Ryan L. , Byrnes Kathleen
Published: June 2020

Pancreatic heterotopia is a well-described entity occurring at multiple abdominal sites, most commonly the stomach and small intestine. They can develop similar disease processes as the pancreas ranging from acute pancreatitis, cyst formation, or neoplasms, most commonly ductal adenocarcinoma. Neuroendocrine tumors (NETs) arising in pancreatic heterotopias are exceedingly rare with only 3 prior published cases. In this article, we describe the first reported case of a NET arising in a jejunal pancreatic heterotopia in a 59-year-old woman presenting with abdominal pain and diarrhea. The submucosal tumor was composed of a well-differentiated NET (World Health Organization grade 1) directly intermixed with a heterotopic pancreas consisting of acinar cells, islet cells, and ducts. This case illustrates that NETs can occur in association with pancreatic heterotopias at any site. Also, the importance for pathologists to recognize that pancreatic heterotopias can give rise to a variety of neoplasms and is not limited to ductal adenocarcinoma.
The first case of fungal endogenous endophthalmitis caused by Aspergillus nidulans: Diagnostic and therapeutic challenge
Authors: Mata-Moret Lucia , Monferrer-Adsuara Clara , Hernández-Bel Laura , Hernández-Garfella Marisa , Torrecillas-Muelas Miriam , Ocete-Mochón Maria Dolores , Cervera-Taulet Enrique
Published: June 2020

Significance:

Fungal endogenous endophthalmitis is an uncommon and potentially blinding infection. Aspergillus is a causative organism in immunocompromized although is virulent enough to afflict immunocompetents. Their propensity to affect macula usually results in a dismal prognosis; thus, improving visual outcome has always been challenging to clinicians. A. nidulans has only rarely been implicated in exogenous endophthalmitis.

Purpose:

To report the first case of A. nidulans endogenous endophthalmitis.

Case report:

An asthmatic 42-year-old female presented with sudden unilateral vision loss due to a submacular abscess that progressively worsened in a matter of days. Vitreous PCR analysis after an urgent vitrectomy was positive for A. nidulans with no active systemic foci found. Oral and intravitreal Voriconazole was prescribed but multiple reactivations led to three vitrectomies in total alongside with subretinal Voriconazole, abscess aspiration, and endolaser. There was complete resolution of the infection and, although visual acuity was poor due to macular scar, enucleation was avoided.

Conclusion:

Although uncommon, we must consider Aspergillus as the causative organism in apparently immunocompetent patients with history of recent systemic corticosteroids treatment, especially if they suffer a broncopulmonary disorder. Aspergillus is an aggressive organism so a high index of suspicion along with early diagnosis and prompt treatment is the key for better outcomes. We highlight A. nidulans as the causative agent as there are no other reported cases.
Endothelium function dependence of acute changes in pulse wave velocity and flow-mediated slowing
Authors: Stoner Lee , Stone Keeron , Zieff Gabriel , Blackwell Jade , Diana Jake , Credeur Daniel P , Paterson Craig , Fryer Simon
Published: June 2020

Flow-mediated slowing (FMS), defined as the minimum pulse wave velocity (PWVmin) during reactive hyperemia, is potentially a simple, user-objective test for examining endothelial function. The purpose of the current study was to determine the effects of a known endothelial dysfunction protocol on arm PWV and PWVmin. Complete data were successfully collected in 22 out of 23 healthy adults (23.8 years [SD 4.1], 16 F, 22.8 kg/m2 [SD 2.8]). Local endothelial dysfunction was induced by increasing retrograde shear stress in the upper arm, through inflation of a distal (forearm) tourniquet to 75 mmHg, for 30 min. Pre- and post-endothelial dysfunction, PWV was measured followed by simultaneous assessment of PWVmin and flow-mediated dilation (FMD). PWV was measured between the upper arm and wrist using an oscillometric device, and brachial FMD using ultrasound. FMD (%) and PWVmin (m/s) were calculated as the maximum increase in diameter and minimum PWV during reactive hyperemia, respectively. Endothelial dysfunction resulted in a large effect size (ES) decrease in FMD (∆ = −3.10%; 95% CI: –4.15, –2.05; ES = −1.3), and a moderate increase in PWV (∆ = 0.38 m/s; 95% CI: 0.07, 0.69; ES = 0.5) and PWVmin (∆ = 0.16 m/s; 95% CI: 0.05, 0.28; ES = 0.6). There was a large intra-individual (pre- vs post-endothelial dysfunction) association between FMD and PWVmin ( r = −0.61; 95% CI: –0.82, –0.24). In conclusion, acute change in PWV and PWVmin are at least partially driven by changes in endothelial function.
Do gender, anxiety, or sleep quality predict mindfulness-based stress reduction outcomes?
Authors: Brown Megan M , Arigo Danielle , Wolever Ruth Q , Smoski Moria J , Hall Martica H , Brantley Jeffrey G , Greeson Jeffrey M
Published: June 2020

Although mindfulness-based stress reduction (MBSR) can improve health and well-being, less is known about factors that predict outcomes. This prospective observational study examined gender and baseline anxiety and sleep quality as predictors of change in emotion regulation and stress symptoms following an 8-week MBSR program. Women and men reported similar improvement in stress symptoms and cognitive reappraisal, whereas men improved more in emotion suppression. Individuals with higher anxiety and worse sleep pre-treatment benefited most in terms of decreased stress. Evaluating pre-treatment characteristics could help determine optimal candidates for MBSR training, and could optimize outcomes for both women and men.
The effects of structured input and traditional instruction on the acquisition of the English causative passive forms: An eye-tracking study measuring accuracy in responses and processing patterns
Authors: Benati Alessandro
Published: June 2020

The present study explores the effects of structured input and traditional instruction on the acquisition of English causative passive forms using online measurements (eye-tracking). Previous empirical research investigating the effects of processing instruction through offline measurements (sentence and discourse) has overall shown positive results for this pedagogical intervention. Research investigating the main factor responsible for the effectiveness of processing instruction has confirmed that it is the structured input component that is the causative factor for the positive effects of processing instruction. The main questions of this study are: (1) what are the effects of structured input and traditional instruction on accuracy when measured by an eye-tracking picture selection task? (2) would possible difference in accuracy between structured input and traditional instruction be accompanied by changes in eye-movement patterns? To provide answers to the two questions formulated in this study, one eye-tracking study was carried out. Fifty-two adult learners (aged 19–21 years) participated and were assigned to one of two groups: structured input ( n = 26) or traditional instruction ( n = 26). Neither instructional groups received explicit information. A pre and post-training design was adopted and the two groups received two different instructional treatments (structured input vs. traditional instruction). Participants were assessed through a picture selection eye-tracking task to measure accuracy and eye-movement patterns while they were processing auditory sentences. Results of the eye-tracking task indicated that the structured input group achieved significantly higher accuracy scores compared to the group receiving traditional instruction. The main findings from the present study reveal that structured input training causes a change in learners’ eye-movement patterns.
The 2009 H1N1 pandemic, vaccine-associated narcolepsy, and the politics of risk and harm
Authors: Oikkonen Venla
Published: June 2020

The article traces the emergence of a new type of vaccine injury—vaccine-associated narcolepsy—following immunization with Pandemrix vaccine during the 2009 H1N1 pandemic in Europe. The article highlights the processual nature of vaccine injury: it shows how vaccine-associated narcolepsy emerges gradually as a recognized object through epidemiological and immunological studies as well as patient organizations’ public discourses. The article argues that despite public recognition of injury, vaccine-associated narcolepsy remains an incongruous object characterized by underlying tensions. These tensions take shape in relation to the history of vaccine injury debates, on the one hand, and the connection between vaccine-associated narcolepsy and non-vaccine-related narcolepsy, on the other. The article shows how these underlying tensions enable a range of mutually incompatible framings and mobilizations through which risk, harm, responsibility, and justice are claimed and negotiated.
The Full Monty? Meaning construction and performative possibilities in media depictions of the male strip show
Authors: Pilcher Katy
Published: June 2020

This article questions the progressive potential of media depictions of male strip shows. I examine two overriding discourses within media representations, comparing these to the experiences of male dancers and female customers gleaned through ethnographic fieldwork in two strip venues. Namely, the media’s portrayal of the masculinity of male strippers as ‘fragile’; together with the construction of dancers as ‘fantasy’ subjects who know ‘what women want’. The article interrogates these constructions in relation to a critique of women’s opportunities to exercise an erotic ‘gaze’; the operation of racist and classist discourses of consuming ‘difference’ and Othering customers; and male dancers’ attempts to construct a viable sense of workplace self in the light of negative constructions of sexual labour.
Development and seismic performance of staggered and out-of-plane joints between concrete-filled steel tubular column and reinforced concrete beam
Authors: Dang Longji , Liang Shuting , Zhu Xiaojun , Yang Jian , Song Yamin
Published: June 2020

This article presents a staggered and out-of-plane connection between concrete-filled steel tubular column and reinforced concrete beam (SOC-TCB). SOC-TCB is taken from the basement roof joint of Suning center, which is a height of 341.85 m in China. In this joint system, the H-shaped steel brackets are welded with steel tube to transfer shear and moment. Moreover, the reinforcing bars are interrupted by steel tube and lapped with steel bracket. To investigate the seismic behavior of SOC-TCB, four types of SOC-TCBs were tested under reversal cyclic loading. The differences between specimens were staggered height and out-of-plane angle. Seismic performance was evaluated based on hysteretic behavior, failure mode, shear deformation, rotational deformation, and energy dissipation. The results showed that the shear deformation of joints was extremely small and the plastic hinges were formed at reinforced concrete beams. Due to insufficient anchorage length of longitudinal bars, anchoring failure was found in the reinforced concrete beams. However, SOC-TCB showed better seismic behavior as long as sufficient anchorage of longitudinal bars was ensured.
Standard versus mini-percutaneous nephrolithotomy for renal stones: a meta-analysis
Authors: Deng Jun , Li Jin , Wang Longwang , Hong Yanyan , Zheng Liangliang , Hu Jieping , Kuang Renrui
Published: June 2020

Objectives:

To compare the standard percutaneous nephrolithotomy and mini-percutaneous nephrolithotomy in order to determine the optimal tract size for patients with renal stones.

Methods:

A systematic search of Web of Science, EMBASE, Cochrane Library, and PubMed databases was conducted for articles published through 20 August 2019, reporting on a comparison of the standard percutaneous nephrolithotomy and mini-percutaneous nephrolithotomy using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Results:

Of 763 studies, 14 were considered for the evidence synthesis. A total of 1980 cases were included. Of these patients, 897 cases underwent standard percutaneous nephrolithotomy, and 1083 cases underwent mini-percutaneous nephrolithotomy. Stone-free rates were 87.6% (786 of 897 patients) for standard percutaneous nephrolithotomy and 87.8% (951 of 1083 patients) for mini-percutaneous nephrolithotomy ( p = 0.57). Tract sizes of 30F and 22–26F in standard percutaneous nephrolithotomy group shorten operation time compared with mini-percutaneous nephrolithotomy ( p = 0.02; p = 0.004; respectively). Leakage ( p = 0.04), bleeding ( p = 0.01), blood transfusion ( p < 0.00001), and renal pelvis perforation ( p = 0.02) were more common in standard percutaneous nephrolithotomy group than in mini-percutaneous nephrolithotomy group. Subgroup analysis showed only blood transfusion for 30F and 22–26F standard percutaneous nephrolithotomy group was more common than mini-percutaneous nephrolithotomy ( p < 0.0001, p = 0.005, respectively).

Conclusions:

Standard percutaneous nephrolithotomy was associated with higher leakage, bleeding, blood transfusion, and renal pelvis perforation, but had a shorter operation time. Tract size of 30F improved the stone-free rate compared with mini-percutaneous nephrolithotomy, but led to more complications. Tract size of 22–26F was no better than 30F or mini-percutaneous nephrolithotomy.
Digital pruning: Agency and social media use as a personal political project among female weightlifters in recovery from eating disorders
Authors: Hockin-Boyers Hester , Pope Stacey , Jamie Kimberly
Published: June 2020

In the past decade, a wealth of research has focused on women and social media. Typically assembled according to the logic of ‘risk’ and ‘exposure’, this extensive work tends to operate within a negative paradigm whereby women’s engagement with the digital produces harmful outcomes for wellbeing. This article makes a novel contribution to this literature by tracing the ways in which women who are in recovery from eating disorders and engaged in weightlifting strategically navigate their social media ‘worlds’ and give meaning to this process. Our data draw on 19 in-depth interviews and our findings examine 2 key themes. First, we challenge the negative paradigm that frames women’s social media use and demonstrate how the digital can support positive wellbeing for women in recovery. Second, we introduce the concept of ‘digital pruning’, a personal political project framed within the language of self-care, which involves unfollowing unhelpful or triggering content.
Assessing the thermal degradation of bonded joints in flat ceramic tiles of building facades by numerical and experimental dynamic analysis
Authors: Lopes Carla MV , Silva Luís , Sequeira Pedro , de Melo Francisco Q
Published: June 2020

Flat ceramic tiles are widely used as protective and aesthetic construction elements in urban building facades. Under the effect of extreme temperatures from the weather seasonality, bonded joints of these tiles undergo thermal cycle’s loads. In this work, a dynamic technique based on vibration metrology is implemented. This procedure consists in the analysis of accelerograms obtained in bonded ceramic tiles from low-intensity impact loads. A corresponding study carried out with finite element modelling allowed an accurate calibration of mechanical parameters of the tile/adhesive pair as well as the estimation of a vibration dissipation factor. Several test specimens subjected to a defined period of thermal cycles stressing were also analysed for the mentioned accelerogram and an expression for the ageing estimation of the mechanical properties of the bonded joints in the tiles was obtained.
Physicians’ and nurses’ decision making to encounter neonates with poor prognosis in the neonatal intensive care unit
Authors: Rafiee Zahra , Rabiee Maryam , Rafati Shiva , Rejeh Nahid , Borna Hajieh , Vaismoradi Mojtaba
Published: June 2020

Background

Decision making regarding the treatment of neonates with poor prognoses is difficult for healthcare staff working in the neonatal intensive care unit (NICU). This study aimed to investigate the attitudes of physicians and nurses about the value of life and ethical decision making when encountering neonates with poor prognosis in the NICU.

Methods

This cross-sectional study was conducted in five NICUs of five hospitals in Tehran city, Iran. The attitudes of 144 pediatricians, gynecologists and nurses were assessed using the questionnaire of attitude toward the value of life and agreement on intensive care management based on three hypothetical case scenarios of neonates with poor prognosis. Data were analyzed using descriptive and inferential statistics via the SPSS software.

Results

The negative agreement on the no initiation of intensive care measures and the discontinuation of resuscitation in neonates with poor prognosis was more than the positive agreement. Also, various factors influenced the participants’ decision making for the provision of care to neonates. Regarding the case scenarios, the participants agreed on the provision of aggressive, conservative, and palliative care with various frequencies. This study confirms the importance of healthcare providers’ perspectives and their impacts on ethical decision making. The participants favored the value or sacredness of life and agreed on the use of all therapeutic measures for saving the lives of neonates with poor prognosis.

Conclusion

More studies are required to improve our understandings of factors influencing ethical decision making by healthcare providers when encountering neonates with poor prognosis in NICUs.
Histone deacetylase-3: Friend and foe of the brain
Authors: D’Mello Santosh R
Published: June 2020

Histone deacetylases (HDACs) are a family of enzymes that deacetylate histones as well as a large number of other nuclear, cytoplasmic, and mitochondrial proteins. The deacetylation of histones transforms chromatin to a transcriptionally repressed state, whereas deacetylation of other cellular proteins regulates their functional activity through modulation of subcellular location, their interaction with other proteins, and in the case of transcription factors, their DNA-binding ability. A compelling body of evidence derived from the utilization of pharmacological inhibitors indicates that histone deacetylases are important regulators of brain development as well as the pathogenesis of neurodegenerative diseases. However, because most of the pharmacological inhibitors used are non-selective with regard to the different members of the HDAC family, the significance of individual HDAC proteins to brain development and degeneration has been difficult to delineate. This review focuses on HDAC3. Experiments conducted using more recently developed isoform selective inhibitors and molecular genetic approaches demonstrate that HDAC3 regulates different steps of neurodevelopment, including neurogenesis, gliogenesis, glial cell fate determination, and the myelination of oligodendrocytes and Schwann cells. However, specific posttranslational modifications and alterations in its binding partners transform HDAC3 from a protein that is beneficial to the brain to one that is neurotoxic. The role of HDAC3 in the promotion of neurodegeneration and the inhibition of recovery after nerve injury is reviewed. The role of HDAC3 in the regulation of memory in the adult and aging brain is also described.

Impact statement

Brain development and degeneration are highly complex processes that are regulated by a large number of molecules and signaling pathways the identities of which are being unraveled. Accumulating evidence points to histone deacetylases and epigenetic mechanisms as being important regulators of these processes. In this review, we describe that histone deacetylase-3 (HDAC3) is a particularly crucial regulator of both neurodevelopment and neurodegeneration. In addition, HDAC3 regulates memory formation, synaptic plasticity, and the cognitive impairment associated with normal aging. Understanding how HDAC3 functions contributes to the normal development and functioning of the brain while also promoting neurodegeneration could lead to the development of therapeutic approaches for neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.
KCa3.1 Impairment Is Not Just a Slow Afterthought in Epilepsy
Authors: Gross Christina
Published: June 2020

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Prostatic Artery Embolization for Benign Prostatic Hyperplasia Treatment: A Russian Multicenter Study in More Than 1,000 Treated Patients
Authors: Kamalov Armais , Kapranov Sergei , Neymark Alexander , Kurbatov Dmitry , Neymark Boris , Karpov Valery , Shaparov Boris
Published: June 2020

Benign prostatic hyperplasia (BPH) is one of the most common diseases of the genitourinary system. The prevalence of BPH increases in men with advancing age. While transurethral resection of the prostate gland entails complications such as retrograde ejaculation, urinary incontinence, hematuria, urethral strictures, bladder neck sclerosis, and other adverse events, it is necessary to apply minimally invasive surgical methods such as superselective embolization of the prostatic arteries (PAE), particularly Proximal Embolization First Then Distal Embolization (PErFecTED). The data from 1,015 BPH patients who underwent endovascular surgery demonstrate the benefits of PErFecTED treatment during 24 months after surgery. Both Quality of Life score and International Prostate Symptom Score were around three times better in the PErFecTED group and remained stable during the entire observation period. However, the technique needs to be improved due to the high risk of postembolization syndrome.
Effect of Smoking on Short-term Postoperative Complications After Elective Upper Extremity Surgery
Authors: Del Core Michael A. , Ahn Junho , Golden Ann S. , Bass Robert L. , Sammer Douglas , Koehler Daniel M.
Published: June 2020

Background: There is a paucity of literature exploring the impact of smoking on short-term complications, readmissions, and reoperations after elective upper extremity surgery using a large multicenter national database. We hypothesized that smokers will have an increased rate of complications, readmissions, and reoperations compared with a cohort of nonsmokers undergoing elective upper extremity surgery. Methods: Patient data were collected from the American College of Surgeons National Surgical Quality Improvement Program database between the years 2012 and 2017. Patients were included if they underwent elective surgery of the upper extremity using 338 predetermined Current Procedural Terminology codes. The data collected were divided into patient demographics, comorbidities, perioperative variables, and 30-day complications. Current smoking status was defined as smoking within 1 year prior to surgery. The incidence of surgical complications, reoperations, and readmissions was compared between the 2 cohorts using multivariable regression analysis. Results: Of the 107 943 patients undergoing elective surgeries of the upper extremity, 73 806 met the inclusion criteria. Of these, 57 986 (78.6%) were nonsmokers in the year prior to surgery, and 15 820 (21.4%) were current smokers. Between these groups, current smokers were younger ( P < .001), more often men ( P < .001), had lower body mass index ( P < .001), and more often underwent procedures that involved bone manipulation ( P < .001). Multivariate regression analysis defined current smoking as significantly associated with overall surgical site complications, superficial surgical site infections, deep surgical site infections, reoperation, and readmission. Conclusion: Current smoking was significantly associated with an increase in all surgical site complications, readmissions, and reoperations after elective upper extremity surgery. Surgeons should consider smoking a modifiable risk factor for postoperative complications and appropriately counsel patients on outcomes and complications given the elective nature of upper extremity surgery.
MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8
Authors: Zhang Chen , Xie Xiongxiong , Yuan Yawen , Wang Yimeng , Zhou Meijuan , Li Xiangzhi , Zhen Peilin
Published: June 2020

Background:

MiR-664 has been demonstrated to play an important role in dermal diseases. However, the functions of miR-664 in ultraviolet B (UVB) radiation-induced keratinocytes damage remain to be elucidated.

Objective:

The present study aimed to investigate the molecular mechanisms under the UVB-induced keratinocytes damage and provide translational insights for future therapeutics and UVB protection.

Methods:

HaCaT cells were transfected with miR-664, either alone or combined with UVB irradiation. Levels of messenger RNA and protein were tested by quantitative real-time polymerase chain reaction and Western blot analyses. Cell proliferation, percentage of apoptotic cells, and expression levels of apoptosis-related factors were measured by Cell Counting Kit-8 assay, flow cytometry assay, and Western blot analysis, respectively.

Results:

We found that a significant increase in miR-664 was observed in UVB-induced HaCaT cells. Overexpressed miR-664 promoted cell vitalities and suppressed apoptosis of UVB-induced HaCaT cells. Additionally, the loss/gain of armadillo-repeat-containing protein 8 (ARMC8) rescued/blocked the effects of miR-664 on the proliferation of UVB-induced HaCaT cells.

Conclusions:

Our data demonstrate that miR-664 functions as a protective regulator in UVB-induced HaCaT cells via regulating ARMC8.
Pseudo-static tests and numerical investigations of triple-tube glass fiber–reinforced polymer and steel buckling-restrained braces
Authors: Ma Jialu , Wang Jinwei , Zhang Lingxin , Zhi Xudong
Published: June 2020

Long-span spatial structures are typical city landmarks. Earthquakes can cause serious damage to these structures, leading to tremendous human injury and financial loss. Therefore, it is essential to develop effective devices to enhance the performance of spatial structures. This article proposes a new triple-tube glass fiber–reinforced polymer and steel buckling-restrained brace device for reticulated shells, which integrates the light weight and high strength advantages of the composite materials. Specimens of scaled glass fiber–reinforced polymer and steel buckling-restrained braces were designed and produced, and pseudo-static tests were performed on these specimens with an MTS machine. Mechanical performance and damages were examined and compared. An elaborate finite-element model was setup, and the accuracy of this model was verified with the test data. In addition, the model was used to investigate the effect of the Pe/ Py ratio on the performance of full-scale triple-tube glass fiber–reinforced polymer and steel buckling-restrained brace devices. Finally, the lower limit of the Pe/ Py ratio for this kind of buckling-restrained brace was obtained by theoretical derivation and numerical parametric analysis.
Synthesis, spectroscopic properties, crystal structures, DFT studies, and the antibacterial and enzyme inhibitory properties of a complex of Co(II) 3,5-difluorobenzoate with 3-pyridinol
Authors: Sertçelik Mustafa
Published: June 2020

A new complex, [Co(DFB)2(3-Pyr)2(H2O)2] (where DFB = 3,5-difluorobenzoate, 3-Pyr = 3-pyridinol), is synthesized and characterized using different techniques (elemental analysis, Fourier transform infrared spectroscopy, and single-crystal X-ray diffraction). Looking at the crystal structure of the complexes, the cobalt atom is coordinated by two nitrogen atoms from two 3-Pyr ligands, two carboxylate oxygen atoms from two DFB anions, and two oxygen atoms from two water molecules. The complex has distorted octahedral geometry around the cobalt atom center complex and crystallizes in the P21/n space group (monoclinic system). Geometry optimization, frequency analysis, and energy quantum chemical calculations on the complex are performed by Density Functional Theory [B3LYP/6-31G (d,p) basis set] to predict the molecular properties. The novel complex is tested against the metabolic isoenzymes human carbonic anhydrases I and II. The novel complex shows Ki values of 317.26 ± 23.25 µM against hCA I and 255.41 ± 48.05 µM against hCA II; the IC50 values for these isoenzymes are 274.37 and 204.33 µM.
The neoliberal Houdini who escaped from (poverty and) prison: Chapo’s narcocorridos, political communication and propaganda
Authors: Larrosa-Fuentes Juan S.
Published: June 2020

Chapo Guzmán was the leader of the Sinaloa Cartel. Although he was a well-known criminal, there is a scarcity of first-hand information about his career. This situation raises a question: how did Guzmán become a public figure without having public exposure? This communicative phenomenon is possible because drug cartels have sophisticated propaganda techniques that allow them to challenge the state not only in the military realm but also in the cultural realm. Among other media, these criminal organizations use narcocorridos, a popular music genre, as a medium for propaganda. This article studies, through a narrative analysis of 66 lyrics, how music, as a form of political communication, is used as propaganda. This study found three main narratives in the narcocorridos dedicated to Guzmán: (i) the origins of this drug dealer; (ii) the masculine features that led him to be a global kingpin; and (iii) his genius for corrupting political systems. These lyrics are propaganda because: (a) they spread knowledge in the form of stories about Guzmán; (b) they create a mythology about the kingpin and the narco-world; and (c) they distort reality by picturing Guzmán as a great man and blur reality by suppressing any reference to the drug wars.
School Nurses on the Front Lines of Healthcare: Infectious Diseases Popularized in the News
Authors: McNickle Lauren , Olympia Robert P.
Published: June 2020

School nurses may deal with students presenting with symptoms associated with infections popularized in the news. Although rare, the implications of missing or misdiagnosing these infections are potentially life-threatening and devastating. We present three students presenting with febrile illnesses associated with neurologic symptoms, a rash, and fatigue, focusing on the initial assessment and management of these students and their associated “hot topic” infection. The authors also discuss two public health organizations, Centers for Disease Control and Prevention (https://www.cdc.gov/) and the World Health Organization (https://www.who.int/), online references for the school nurse to research both emerging and common infectious diseases.
Framework for 21st Century School Nursing Practice™: Clarifications and Updated Definitions
Authors:   National Association of School Nurses
Published: June 2020

The National Association of School Nurses developed the Framework for 21st Century School Nursing Practice™ (Framework) to guide school nursing practice and help school nurses articulate their role to educators. Since its introduction, the Framework has been accepted and adopted by many. At the same time, several misunderstandings and misinterpretations of the Framework have come to light. The purpose of this article is to clarify the terminology in order to create a common understanding among practicing school nurses to be able to implement the Framework more fully and with integrity.
Gilteritinib in the treatment of relapsed and refractory acute myeloid leukemia with a FLT3 mutation
Authors: Chew Serena , Mackey Melissa C. , Jabbour Elias
Published: June 2020

Acute myeloid leukemia (AML) is a malignancy of uncontrolled proliferation of immature myeloid blasts characterized by clonal evolution and genetic heterogeneity. FMS-like tyrosine kinase 3 (FLT3) mutations occur in up to a third of AML cases and are associated with highly proliferative disease, shorter duration of remission, and increased rates of disease relapse. The known impact of activating mutations in FLT3 in AML on disease pathogenesis, prognosis, and response to therapy has led to the development of tyrosine kinase inhibitors targeting FLT3. Gilteritinib is a potent, second generation inhibitor of both FLT3 and AXL, designed to address the limitations of other FLT3 inhibitors, particularly in targeting mechanisms of resistance to other drugs. In this review, we present comprehensive data on recent and ongoing studies evaluating the role of gilteritinib in the relapsed and refractory FLT3 mutated AML setting.
Primary Care Service Utilization Among People at High Risk of Fatal Opioid Overdose: A Short Communication on an Autopsy Study
Authors: Jones Matthew , Bradshaw Ceri , Jones Jenna , John Ann , Snooks Helen , Watkins Alan
Published: June 2020

Objectives: We sought to explore the sociodemographics and primary care service utilization among people who died from opioid overdose and to assess the possibility of using this information to identify those at high risk of opioid overdose using routine linked data. Methods: Data related to decedents of opioid overdose between January 1, 2012 and December 31, 2015 were linked with general practitioner (GP) records over a period of 36 months prior to death. Results: Of n = 312 decedents of opioid overdose, 73% were male (n = 228). Average age at death was 40.72 (SD 11.92) years. A total of 63.8% of the decedents were living in the 2 most deprived quintiles according to the Welsh Index of Multiple Deprivation. Over 80% (n = 258) of the decedents were recorded as having at least 1 GP episode during the 36-month observation period prior to death. The median number of episodes per decedent was 75 [38-118]. Overall, 31.8% (n = 82) of decedents with at least 1 GP episode received a prescription for a proton pump inhibitor and 31% (n = 80) were prescribed a broad-spectrum antibiotic. According to their GP records, less than 10% were referred to or receiving specialist drug treatment (n = 24, 9.3%); or were known to be drug dependent (n = 21, 8.14%), or a drug user (n = 5, 1.94%). In all, 81% were recorded as smokers (n = 209) and 10.5% as ex-smokers (n = 27). Conclusions: The majority of decedents of opioid overdose were in contact with GP services prior to death. GPs are either often unaware of high-risk opioid use, or rarely record details of opioid use in patient notes. It is possible that GP awareness of high-risk opioid use could be increased. For example, awareness of the risks associated with opioid use, and the relationship between the sociodemographic and clinical characteristics of opioid overdose decedents could be raised using educational materials prominently displayed in waiting areas. Clinicians in primary care may be in an excellent position to intervene in problematic opioid use.
Modified Infrabrow Excision Blepharoplasty for Severity of Medial Blepharochalasia
Authors: Jung Gyu Sik
Published: June 2020

Infrabrow excision blepharoplasty can be a satisfactory and useful alternative for patients with blepharochalasia. Sixty patients underwent modified infrabrow excision blepharoplasty from March 2017 to February 2018. The design of the skin excision was modified according to the severity of the medial blepharochalasia: (1) excision up to the medial limbus was performed if there was no medial blepharochalasia, (2) excision up to the medial epicanthus was performed if there was mild medial blepharochalasia, and (3) excision with triangular back cut was performed if there was moderate-to-severe medial blepharochalasia. The surgical method included (1) skin excision, (2) orbicularis oculi muscle excision, (3) orbicularis oculi muscle closure, and (4) skin closure. The mean postoperative follow-up period was 9 months, and the photographic results were collected retrospectively and evaluated. There were no complications related to surgery in terms of the resulting scar and dysesthesia. The mean operative time was 55 minutes. Patient satisfaction was very high in terms of both aesthetic outcome and comfort. Modified infrabrow excision blepharoplasty can be an easy and satisfactory alternative in a selected group of patients.
Combining pullout suture and retrograde screw fixation for anterior cruciate ligament tibial eminence avulsion fractures: A case report
Authors: Hiranaka Takaaki , Furumatsu Takayuki , Tanaka Takaaki , Okazaki Yuki , Kodama Yuya , Kamatsuki Yusuke , Masuda Kenji , Seno Noritaka , Ozaki Toshifumi
Published: June 2020

This report describes a novel arthroscopic technique for the treatment of anterior cruciate ligament (ACL) tibial eminence avulsion fractures. A 16-year-old boy who was diagnosed with a left ACL tibial eminence avulsion fracture was treated by arthroscopic fixation. Two bone tunnels were created from the anterior tibial cortex into the fracture bed, and a strong suture passed through the ACL just above its insertion was pulled out through them for reduction and fixation. A retrograde cannulated screw fixation was added for stronger fixation. Weight-bearing and range of motion exercises were started immediately after surgery. Radiographically, bone union was obtained 6 months postoperatively. During second-look arthroscopy (24 months postoperatively), there was no loss of reduction and no subsequent meniscal or cartilage injuries. At that point, the Lysholm score was 95, and the International Knee Documentation Committee score was 96.
A Case of Idiopathic Acquired Neonatal Bell’s Palsy
Authors: Pierick Alyson R. , Jenkins Elan
Published: June 2020

Neonatal idiopathic Bell’s palsy is a very rare diagnosis with only a few previously published case reports of infants responding well to oral corticosteroid use. This trial therapy likely comes from adult data where clinical outcomes are improved following steroid use, although the data in childhood cases are equivocal. In this specific population of infants <28 days of age at presentation, the most common causes of Bell’s palsy include congenital, birth trauma, and syndromic (likely with no indication for steroid treatment). In those with noncongenital Bell’s palsy, infectious and structural causes should first be ruled out. In this article, we present the third known case report of a 16-day-old presenting with acute Bell’s palsy with negative infectious workup and normal brain imaging. He was treated with a 7-day course of oral prednisone and had eventual resolution of symptoms.
Struggles of Korean Second-Generation Leaders: Leaving the Immigrant Church
Authors: Hong Eunice
Published: June 2020

The Korean immigrant church has served as not only a religious institution but also a cultural base for the first generation of immigrants, who have a common interest in keeping their traditional values. Such an emphasis, however, has resulted in conflicts between the first and second generations. The purpose of this study is to explain the struggles of second-generation Korean American leaders that led them away from the first-generation immigrant church. Two main elements of the Asian culture emerged as the source of the intercultural identity struggle: (1) striving to maintain the honor balance and (2) struggling with due order.
High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential
Authors: Busque Lambert , Sun Maxine , Buscarlet Manuel , Ayachi Sami , Feroz Zada Yassamin , Provost Sylvie , Bourgoin Vincent , Mollica Luigina , Meisel Marlies , Hinterleitner Reinhard , Jabri Bana , Dubé Marie-Pierre , Tardif Jean-Claude
Published: June 2020

Clonal hematopoiesis of indeterminate potential (CHIP) is predictive of hematological cancers and cardiovascular diseases, but the etiology of CHIP initiation and clonal expansion is unknown. Several lines of evidence suggest that proinflammatory cytokines may favor mutated hematopoietic stem cell expansion. To investigate the potential link between inflammation and CHIP, we performed targeted deep sequencing of 11 genes previously implicated in CHIP in 1887 subjects aged >70 years from the Montreal Heart Institute Biobank, of which 1359 had prior coronary artery disease (CAD), and 528 controls did not. We assessed association of CHIP with log transformed high-sensitivity C-reactive protein (hs-CRP), a validated biomarker of inflammation. CHIP was identified in 427 of the 1887 subjects (22.6%). CHIP mutations were more frequently identified in DNMT3A (11.6%) and TET2 (6.1%), with a higher proportion of TET2 mutations occurring in controls than in patients with CAD (9.0% vs 4.9%, P < .001). CHIP carriers had 21% higher hs-CRP levels compared with their noncarrier counterparts (eβ = 1.21, 95% confidence interval [CI]: 1.08 to 1.36; P = .001). A similar effect was observed in the subgroup of patients with known CAD (eβ = 1.22, 95% CI: 1.06 to 1.41; P = .005). These findings confirm the association between inflammation and CHIP. This association may open investigational avenues aimed at documenting mechanisms linking inflammation to clonal progression and ultimately supports prevention interventions to attenuate CHIP’s impact on cardiovascular disease and cancer.
New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT
Authors: Elfeky Reem , Lucchini Giovanna , Lum Su-Han , Ottaviano Giorgio , Builes Natalia , Nademi Zohreh , Battersby Alexandra , Flood Terence , Owens Stephen , Cant Andrew J. , Young Helen , Greener Sinéad , Walsh Patrick , Kavanagh David , Annavarapu Srinivas , Rao Kanchan , Amrolia Persis , Chiesa Robert , Worth Austen , Booth Claire , Skinner Roderick , Doncheva Bilyana , Standing Joseph , Gennery Andrew R. , Qasim Waseem , Slatter Mary , Veys Paul
Published: June 2020

This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent 474 HSCTs at 2 supraregional United Kingdom centers. At a median of 153 days post-HSCT, TA-TMA occurred among 25 of 441 evaluable cases (5.6%) with no evidence of center variation. Sex, underlying disease, intensity of the conditioning, total body irradiation–based conditioning, the use of calcineurin inhibitors, venoocclusive disease, and viral reactivation did not influence the development of TA-TMA. Donor type: matched sibling donor/matched family donor vs matched unrelated donor vs mismatched unrelated donor/haplo-HSCT, showed a trend toward the development of TA-TMA in 1.8% vs 6.1% vs 8.3%, respectively. Presence of active comorbidity was associated with an increased risk for TA-TMA; 13% vs 3.7% in the absence of comorbidity. The risk of TA-TMA was threefold higher among patients who received >1 transplant. TA-TMA rates were significantly higher among patients with acute graft-versus-host disease (aGVHD) grades III to IV vs aGVHD grade 0 to II. On multivariate analysis, the presence of active comorbidity, >1 transplant, aGVHD grade III to IV were risk factors for TA-TMA (odds ratio [OR]: 5.1, 5.2, and 26.9; respectively), whereas the use of cyclosporine A/tacrolimus-based GVHD prophylaxis was not a risk factor for TA-TMA (OR: 0.3). Active comorbidity, subsequent transplant, and aGVHD grades III to IV were significant risk factors for TA-TMA. TA-TMA might represent a form of a vascular GVHD, and therefore, continuing control of aGVHD is important to prevent worsening of TA-TMA associated with GVHD.
Dickkopf-related protein 3 is a novel biomarker for chronic GVHD after allogeneic hematopoietic cell transplantation
Authors: Inamoto Yoshihiro , Martin Paul J. , Lee Stephanie J. , Momin Amin A. , Tabellini Laura , Onstad Lynn E. , Pidala Joseph , Flowers Mary E. D. , Lawler Richard L. , Katayama Hiroyuki , Hanash Samir , Hansen John A.
Published: June 2020

To identify plasma biomarkers associated with fibrotic mechanisms of chronic graft-versus-host disease (GVHD), we used multiplex mass spectrometry with pooled samples for biomarker discovery in comparing proteomic profiles between patients with newly diagnosed sclerotic chronic GVHD (n = 21), those with newly diagnosed nonsclerotic chronic GVHD (n = 33), and those without chronic GVHD (n = 20). Immunoassay was used to measure protein concentrations of individual discovery samples and 186 independent verification samples. The discovery mass spectrometry analysis identified 2 candidate proteins with at least 1.5-fold difference in sclerotic GVHD: Dickkopf-related protein 3 (DKK3) and interleukin-1 receptor accessory protein (IL1RAP). Analysis of individual discovery samples by immunoassay showed that DKK3, a modulator of the Wnt signaling pathway, was a biomarker for both sclerotic and nonsclerotic chronic GVHD. Verification analysis of 186 patients confirmed that elevated plasma DKK3 concentrations were associated with chronic GVHD, regardless of the presence or absence of sclerosis, and that the area under the receiver operating characteristic curve was 0.85 for association of DKK3 concentrations with chronic GVHD. Multiple linear regression analysis showed that chronic GVHD with or without steroid treatment and patient age were independently associated with DKK3 concentrations. Patients with high DKK3 concentrations had a higher nonrelapse mortality than those with low concentrations. The lower IL1RAP concentrations in patients with sclerotic GVHD compared with other conditions in the discovery cohort were not confirmed in the verification cohort. DKK3 is a novel biomarker for chronic GVHD. Further studies are needed to determine the biological functions of DKK3 in the pathogenesis of chronic GVHD.