bluuebunny/crossref_metadata_2025 huggingface dataset:
Panomics reveals patient-individuality as the major driver for colorectal cancer progression
Authors: Praus Friederike , Künstner Axel , Sauer Thorben , Kohl Michael , Kern Katharina , Deichmann Steffen , Végvári Ákos , Keck Tobias , Busch Hauke , Habermann Jens K , Gemoll Timo
Published: October 2022

Colorectal cancer (CRC) is one of the most prevalent cancers, with over one million new cases. The prognosis of CRC considerably depends on the disease stage and metastatic status. As precision oncology for patients with CRC continues to improve, this study aims to integrate genomic, transcriptomic, and proteomic analyses to identify significant expression differences during colorectal progression using a unique set of paired patient samples concerning tumor heterogeneity.

We analyzed fresh-frozen tissue samples of matched healthy colon mucosa, colorectal carcinoma, and liver metastasis from same patients prepared under strict cryogenic conditions. While somatic mutations of known cancer-related genes were analyzed using Illumina’s TruSeq Amplicon Cancer Panel, the transcriptome was assessed comprehensively using Clariom D microarrays. The global proteome was evaluated by liquid chromatography-coupled mass spectrometry (LC-MS/MS) and validated by two-dimensional difference in-gel electrophoresis. Subsequent unsupervised principal component clustering, statistical comparisons, and gene set enrichment analyses were calculated using differential expression results.

While panomics revealed low RNA and protein expression of CA1, CLCA1, MATN2, AHCYL2, and FCGBP in malignant tissues compared to healthy colon mucosa, no differentially expressed RNA or protein targets were detected between tumor and metastatic tissues. Subsequent intra-patient comparisons revealed highly specific expression differences (e.g., SRSF3, OLFM4, and CEACAM5) associated with a patient-individual transcriptome and proteome.

In conclusion, the results highlight the importance of inter- and intra-tumor heterogeneity alongside the individual, patient-paired evaluation for clinical studies. Next to changes among groups reflecting colorectal cancer progression, we identified significant expression differences between patient-individual normal colon mucosa, primary tumor, and liver metastasis, which could speed up the implementation of precision oncology in the future.
Feasibility and preliminary effectiveness of behavioral activation for cancer patients with depression
Authors: Hirayama Takatoshi , Ogawa Yuko , Yanai Yuko , Shindo Akie , Tanaka Moeko , Suzuki Shin-ichi
Published: October 2022

Background

Behavioral activation (BA) is a psychotherapy that directly approaches patients’ most valued daily activities. BA may be particularly useful for treating depression in patients with cancer, but there is insufficient evidence in this population. This study aimed to verify the feasibility and preliminary effectiveness of BA for patients with depression with all types and stages of cancer.

Methods

This pre–post study without a control group was conducted in patients with cancer and depression. The program completion rate was compared with those of previous studies to verify feasibility. To examine the preliminary effectiveness of BA, outcomes were evaluated four times: before and immediately after the program, and 2 weeks and 3 months after the program ended. The primary outcome was the remission rate of depression determined using a binomial test and the 17-item version of the GRID Hamilton Rating Scale for Depression (HAMD17). Secondary outcomes were self-reported depression, anxiety, quality of life, changes in behavior, values, and perceived reward of activity and environmental factors. Pre- and post-program data were compared using paired-samples t-tests, and data obtained at four time points were analyzed using one-way repeated measures analysis of variance. Hedge’s g was computed for calculating effect sizes.

Results

Participants were recruited from February 2018 to January 2022. Of the 68 patients who were initially recruited, 32 were registered. The completion rate was 75% (24/32), which was similar to previous studies. The total HAMD17 score significantly improved after the program with large effect sizes (Hedge’s g =1.95). The remission rate of depression was 62.5% (20/32), which was above the defined threshold value (30%). All but two secondary outcomes significantly improved after the program (p<0.05).

Conclusions

This study suggested the feasibility and preliminary effectiveness of BA for patients with depression. To establish further evidence for the use of BA in patients with cancer, randomized controlled trials are needed.

Trial Registration

University Hospital Medical Information Network (UMIN CTR) UMIN000036104. Registered 6 March 2019 - Retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000041129
Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms
Authors: Poet Mallorie , Vigier Nathalie , Bouret Yann , Jarretou Gisèle , Bendahhou Saïd , Montanes Maryline , Thibon Fanny , Counillon Laurent
Published: October 2022

Lithium (Li) has a wide range of uses in science, medicine and industry but its isotopy is underexplored, except in nuclear science and in geoscience. 6Li and 7Li isotopic ratio exhibits the second largest variation on Earth’s surface and constitutes a widely used tool for reconstructing past oceans and climates. As large variations have been measured in mammalian organs, plants or marine species, and as 6Li elicits stronger effects than natural Li (~95% 7Li) a central issue is the identification and quantification of biological influence of Li isotopes distribution. We show here that membrane ion channels and Na+-Li+/H+ exchangers (NHEs), strongly fractionate Li isotopes. This systematic 6Li enrichment is driven by membrane potential for channels, and by intracellular pH for NHEs, where it displays cooperativity, a hallmark of dimeric transport. Evidencing that transport proteins discriminate between isotopes differing by one neutron, opens new avenues for transport mechanisms, Li physiology, and paleoenvironments.
OligoArchive-DSM: Columnar Design for Error-Tolerant Database Archival using Synthetic DNA
Authors: Marinelli Eugenio , Yan Yiqing , Magnone Virginie , Dumargne Marie-Charlotte , Barbry Pascal , Heinis Thomas , Appuswamy Raja
Published: October 2022

The surge in demand for cost-effective, durable long-term archival media, coupled with density limitations of contemporary magnetic media, has resulted in synthetic DNA emerging as a promising new alternative. Today, the limiting factor for DNA-based data archival is the cost of writing (synthesis) and reading (sequencing) DNA. Newer techniques that reduce the cost often do so at the expense of reliability, as they introduce complex, technology-specific error patterns. In order to deal with such errors, it is important to design efficient pipelines that can carefully use redundancy to mask errors without amplifying overall cost. In this paper, we present OligoArchive-DSM (OA-DSM), an end-to-end DNA archival pipeline that can provide error-tolerant data storage at low read/write costs. Central to OA-DSM is a database-inspired columnar encoding technique that makes it possible to improve efficiency by enabling integrated decoding and consensus calling during data restoration.
C1orf112 is a novel regulator of interstrand crosslink that decreases FIGNL1-RAD51 interaction
Authors: Pinedo-Carpio Edgar , Dessapt Julien , Villot Romain , Sacre Lauralicia , Malina Abba , Boulais Jonathan , Lavoie Elise G. , Luo Vincent , Lazaratos Ana-Maria , Côté Jean-François , Mallette Frédérick , Guarné Alba , Fradet-Turcotte Amelie , Orthwein Alexandre
Published: October 2022

Interstrand DNA crosslinks (ICLs) represent complex lesions that block essential biological processes, including DNA replication, recombination, and transcription. Several pathways have been involved in ICL repair, in particular nucleotide excision repair (NER), translesion DNA synthesis (TLS), Fanconi anemia (FA), and homologous recombination (HR). Still, the extent of factors involved in the resolution of ICL-induced DNA double-strand breaks (DSBs) remains poorly defined. Using CRISPR-based genome-wide screening, we identified the poorly characterized C1orf112 (also known as Apolo1) as a novel sensitizer to the clinically relevant ICL-inducing agent mafosfamide. Consistently, we noted that low expression of C1orf112 correlates with increased sensitivity to a series of ICL agents and PARP inhibitors in a panel of cell lines. We showed that lack of C1orf112 does not impact the initial recruitment and ubiquitylation of FANCD2 at the ICL site but rather impairs the resolution of RAD51 from ICL-induced DSBs, thereby compromising homology-directed DNA repair pathways. Our proximal mapping of C1orf112 protein neighbours coupled to structure-function analysis revealed that C1orf112, through its WCF motif, forms a complex with the N-terminal domain of the AAA+ ATPase FIGNL1 and regulates the interaction of FIGNL1 with RAD51. Our work establishes the C1orf112-FIGNL1 complex as an integral part of the HR-mediated response to ICLs by regulating the unloading of RAD51 during ICL repair.
Mitochondrial Function is Preserved Under Cysteine Starvation via Glutathione Catabolism in NSCLC
Authors: Ward Nathan P. , Yoon Sang Jun , Flynn Tyce , Sherwood Amanda , Madej Juliana , DeNicola Gina M.
Published: October 2022

Cysteine metabolism occurs across cellular compartments to support diverse biological functions and prevent the induction of ferroptosis. Though the disruption of cytosolic cysteine metabolism is implicated in this form of cell death, it is unknown whether the substantial cysteine metabolism resident within the mitochondria is similarly pertinent to ferroptosis. Here, we show that despite the rapid depletion of intracellular cysteine upon loss of extracellular cystine, cysteine-dependent synthesis of Fe-S clusters persists in the mitochondria of lung cancer cells. This promotes a retention of respiratory function and a maintenance of the mitochondrial redox state. Under these limiting conditions, we find that mitochondrial glutathione sustains the function of the Fe-S proteins critical to oxidative metabolism. This is achieved through CHAC1 catabolism of the cysteine-containing tripeptide within the mitochondrial matrix. We find that disrupting Fe-S cluster synthesis under cysteine restriction protects against the induction of ferroptosis, suggesting that the preservation of mitochondrial function is antagonistic to survival under starved conditions. Overall, our findings implicate mitochondrial cysteine metabolism in the induction of ferroptosis and reveal a novel mechanism of mitochondrial resilience in response to nutrient stress.
Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis
Authors: Tschuck Juliane , Theilacker Lea , Rothenaigner Ina , Weiß Stefanie A. I. , Akdogan Banu , Müller Constanze , Graf Roman , Brandner Stefanie , Pütz Christian , Rieder Tamara , Schmitt-Kopplin Philippe , Zischka Hans , Schorpp Kenji , Hadian Kamyar
Published: October 2022

Objective

Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. The recent decade of research has uncovered many regulators driving ferroptosis as well as cellular gatekeepers preventing ferroptosis. Yet, many processes and networks remain to be elucidated.

Methods and results

In this study, we performed a chemical screen using small molecules with known mode of action and identified two agonists (Turofexorate and Fexaramine) of the nuclear receptor Farnesoid X Receptor (FXR), also known as NR1H4, to suppress ferroptosis, but not apoptosis or necroptosis. Further, we demonstrate that in liver cells with high FXR protein levels, inhibition of FXR sensitizes cells to undergo ferroptotic cell death, while activation of FXR inhibits ferroptosis. Importantly, FXR also inhibits ferroptosis in ex vivo primary mouse hepatocytes. Activation of FXR by Turofexorate and Fexaramine significantly reduces lipid peroxidation. Mechanistically, overexpression of FXR or activation of FXR by bile acids upregulates the ferroptosis-inhibitory regulators FSP1, PPARα, GPX4, SCD1, and ACSL3 to reduce peroxidized lipids and to counteract ferroptosis.

Conclusion

In this study, we demonstrate that activation of FXR inhibits ferroptotic cell death via upregulation of a number of ferroptosis-inhibitory proteins (FSP1, PPARα, GPX4, SCD1, and ACSL3) to reduce lipid peroxidation. Hence, modulating FXR activity may be beneficial to overcome ferroptosis-mediated degenerative diseases.
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis
Authors: Feng Shuang , Manley James L.
Published: October 2022

Nucleoli are the major cellular compartments for the synthesis of rRNA and assembly of ribosomes, the macromolecular complexes responsible for protein synthesis. Given the abundance of ribosomes, there is a huge demand for rRNA, which indeed constitutes ∼80% of the mass of RNA in the cell. Thus, nucleoli are characterized by extensive transcription of multiple rDNA loci by the dedicated polymerase, RNA polymerase (Pol) I. However, in addition to producing rRNAs, there is considerable additional transcription in nucleoli by RNA Pol II as well as Pol I, producing multiple noncoding (nc) and, in one instance, coding RNAs. In this review, we discuss important features of these transcripts, which often appear species-specific and reflect transcription antisense to pre-rRNA by Pol II and within the intergenic spacer regions on both strands by both Pol I and Pol II. We discuss how expression of these RNAs is regulated, their propensity to form cotranscriptional R loops, and how they modulate rRNA transcription, nucleolar structure, and cellular homeostasis more generally.
Lorlatinib and compound mutations in ALK+ large-cell neuroendocrine lung carcinoma: a case report
Authors: Wiedemann Christiane , Kazdal Daniel , Cvetkovic Jelena , Kunz Julia , Fisch David , Kirchner Martina , Kriegsmann Mark , Sueltmann Holger , Heussel Claus-Peter , Bischoff Helge , Thomas Michael , Stenzinger Albrecht , Christopoulos Petros
Published: October 2022

Large-cell neuroendocrine lung carcinoma (LCNEC) is a high-grade neoplasm with median survival of 1 year and limited therapeutic options. Here, we report the unusual case of a 47-year-old female smoker with stage IV LCNEC featuring EML4-ALK variant 2 (E20:A20), wild-type TP53/RB1 and low tumor mutational burden of 3.91 mut/Mb. Despite early progression within 3 months under crizotinib, a durable response was achieved with alectinib. Oligoprogression in the left breast 10 months later was treated by surgery, followed by switch to ceritinib upon multifocal progression and detection of ALK:p.V1180L in the mastectomy specimen, but without success. Another rebiopsy revealed ALK:p.L1196M, but the tumor did not respond to brigatinib or carboplatin/pemetrexed, before stabilization under lorlatinib. Diffuse progression 8 months later with detection of ALK:p.L1196M/p.G1202R and p.L1196M/p.D1203N evolving from the previous p.L1196M did not respond to chemoimmunotherapy, and the patient succumbed with an overall survival (OS) of 37 months. This case illustrates the importance of molecular profiling for LCNEC regardless of smoking status, and the superiority of next-generation ALK inhibitors compared to crizotinib for ALK+ cases. Lorlatinib retained efficacy in the heavily pretreated setting, while its upfront use could possibly have prevented the stepwise emergence of compound ALK mutations. Furthermore, the disease course was more aggressive and OS shorter compared to the V2/TP53wt ALK+ lung adenocarcinoma, while crizotinib, ceritinib and brigatinib did not confer the benefit expected according to NGS results, which also underline the need for more potent drugs against ALK in the high-risk setting of neuroendocrine histology.
On the use of Hirshfeld surfaces for estimating atomic charges in ionic species: crystal structure of the natural ilmenite (Mg0.4168Fe0.5832)TiO3
Authors: Almeida Leandro Fernandes de , Rodrigues Bernardo Lages
Published: October 2022

We performed an analysis by single-crystal X-ray diffraction and scanning electron microscopy (SEM), aiming to solve and refine the structure of an ilmenite single crystal [(Fe0.5832Mg04168)TiO3] from the city of Ouvidor (Goiás, Brazil). Hirshfeld partition was used to explore the values of w(r), d
norm and curvedness that achieve complementary surfaces for neighbouring atoms in this ionic system, and the subsequent impact on the charge distribution, allowing the ionic radius and the charges of the ilmenite sample to be modelled.
Big data analytics capabilities and green supply chain performance: investigating the moderated mediation model for green innovation and technological intensity
Authors: Al-Khatib Ayman Wael
Published: October 2022

Purpose

This study investigates the impact of big data analytics capabilities on green supply chain performance. Moreover, it assesses the mediating effect of the green innovation and moderating effect of technological intensity.

Design/methodology/approach

This study is based on primary data that were collected from the food and beverages manufacturing sector operating in Jordan. A total of 420 samples were used for the final data analysis. Data analysis was performed via structural equation modeling (SEM) using SmartPLS 3.3.9.

Findings

The results of the data analysis supported a positive relationship between big data analytics capabilities and the green supply chain performance as well as a mediating effect of green innovation. It was confirmed that technological intensity moderated the relationship of green innovation on green supply chain performance.

Research limitations/implications

The study faced many limitations such as the method of collecting primary data, which relied on a questionnaire only and the use of cross-sectional data, as well as studying one context and in one country.

Practical implications

The findings can guide managers and policymakers in the Jordanian food and beverage manufacturing sector on how to manage organizational capabilities related to big data analytics to enhance green supply chain performance and improve green innovation in these firms.

Originality/value

This study developed a theoretical and empirical model to investigate the relationship between big data analytics capabilities, green innovation, technological intensity and green supply chain performance. This study offers new theoretical and managerial contributions that add value to the supply chain management and innovation literature by testing the moderated mediation model of these constructs in the food and beverages manufacturing sector in Jordan.
Circuit analysis and modeling of a soft-switching pulse power supply based on full-bridge inverter for DBD application
Authors: Tang Xiongmin , Jiang Tianhong , Chen Weizheng , Lin ZhiHong , Zhou Zexin , Yongquan Chen , Zhang Miao
Published: October 2022

Purpose

How to use a simple and classical topology to provide a high-efficiency excitation voltage for dielectric barrier discharge (DBD) loads is one of the primary problems to be solved for DBD application fields.

Design/methodology/approach

To address the issue, a set of modes that can generate a high-efficiency pulse excitation voltage in a full-bridge inverter are adopted. With the set of modes, the unique equivalent circuit of DBD loads and the parasitic parameter of the step-up transformer can be fully used. Based on the set of modes, a control strategy for the full-bridge inverter is designed. To test the performance of the power supply, a simulation model is established and an experimental prototype is made with a DBD excimer lamp.

Findings

The simulation and experimental results show that not only a high-efficiency excitation voltage can be generated for the DBD load, but also the soft switching of all power switch is realized. Besides this, with the set of modes and the proposed control strategy, the inverter can operate in a high frequency. Compared with other types of power supplies, the power supply used in the paper can fully take advantage of the potential of the excimer lamp at the same input power.

Originality/value

This work considers that how to use a simple and classical topology to provide a high-efficiency excitation voltage for DBD loads is one of the primary problems to be solved for DBD application fields.
Toward a critical technical practice in disaster risk management: lessons from designing collaboration initiatives
Authors: Lallemant David , Bicksler Rebecca , Barns Karen , Hamel Perrine , Soden Robert , Bannister Steph
Published: October 2022

Purpose

Despite decades of social science research into disasters, practice in the field continues to be informed largely from a technical perspective. The outcome is often a perpetuation of vulnerability, as narrowly defined technical interventions fail to address or recognize the ethical, historical, political and structural complexities of real-world community vulnerability and its causes. The authors propose that addressing this does not require a rejection of technical practice, but its evolution into a critical technical practice – one which foregrounds interdisciplinarity, inclusion, creativity and reflexivity, as means to question the assumptions, ideologies and delimited solutions built into the technical tools for understanding risks.

Design/methodology/approach

The authors present findings from three events they designed and facilitated, aimed at rethinking the engineering pedagogy and technical practice of disaster risk management. The first was a 2-day “artathon” that brought together engineers, artists and scientists to collaborate on new works of art based on disaster and climate data. The second was the Understanding Risk Field Lab, a 1-month long arts and technology un-conference exploring critical design practices, collaborative technology production, hacking and art to address complex issues of urban flooding. The third was a 4-month long virtual workshop on responsible engineering, science and technology for disaster risk management.

Findings

Each of these events uncovered and highlighted the benefits of interdisciplinary collaboration and reflexivity in disaster risk modeling, communication and management. The authors conclude with a discussion of the key design elements that help promote the principles of a critical technical practice.

Originality/value

The authors propose “critical technical practice” which foregrounds principles of interdisciplinarity, inclusion, creativity and reflexivity, as a means to question the assumptions, ideologies and delimited solutions built into the technical tools for understanding climate and disaster risk.
Bab Al Qasr Hotel & Residence: sustaining business while housing COVID-19 patients
Authors: Alfalasi Alyazyah , Ahmad Syed Zamberi
Published: October 2022

Learning outcomes

This case study aims to yield the following learning outcomes: understand the key performance indicators of successful human resource management (HRM) in the hospitality and tourism sector, especially during pandemics; identify the various concepts and strategies of HRM and recruitment over a short period; conceptualize the types of HRM practices such as safety and health, recruitment and promotion and rewards when facing pandemic conditions as well as the handling of hotel staff in strained times; evaluate the crisis management solutions used by human resources to lower the employee turnover rate; and develop a crisis management plan from a human resource standpoint in a pandemic situation.

Case overview/synopsis

A five-star hotel in Abu Dhabi, United Arab Emirates (UAE), Bab Al Qasr Hotel & Residence (BAQHotel) opened in October 2016. In April 2020, the hotel began accepting patients with COVID-19 in conjunction with the Abu Dhabi’s Healthcare Company (SEHA), as a support to the UAE Government, through Department of Culture and Tourism Abu Dhabi (DCTAD), to meet the local needs and sustain business during these unforeseen circumstances, which heavily impacted the whole World. Samer Majari, the Human Resource Director of BAQ hotel was responsible for recruiting and supervising delegates, while ensuring the comfort of hotel staff, arranging for their transportation, catering, safety and well-being. To combat the high staff turnover, including COVID-19-positive staff, Majari reviewed the existing staff model; divided the staff into two groups for providing services to both sides of the hotel; arranged for separate accommodations, food and transportation; and retained the existing resources and recruited new workers. This study aims to provide management solutions that concern hiring of staff from the existing UAE market and highlights ways of creating a lower staff turnover rate through incentives and compensations, while also managing staff by motivating them and also safeguarding them against COVID-19.

Complexity academic level

This case study intends to provide a context for creative solutions to human resource challenges facing organizations during a pandemic. It also involves swift responses to crises faced by HR managers and the immediate solutions required. Therefore, this case study can be used in undergraduate level courses for students pursuing a bachelor’s or a master’s degree in HRM, hospitality management, crisis management or international business studies. Moreover, this case study can be used for corporate training and to help hospitality industry staff, mid-level human resource managers and organizational development practitioners to better understand crisis management in their hotels.

Supplementary materials

Teaching notes are available for educators only.

Subject code

CSS 6: Human Resource Management
COVID-19 and service innovation strategies of tourism and hospitality SMEs in an emerging country
Authors: Bianchi Constanza
Published: October 2022

Purpose

This study aims to examine the impact of COVID-19 on tourism and hospitality small and medium-sized enterprises (SMEs) in an emerging country located in Latin America and identifies service innovation strategies adopted by these firms to survive a prolonged crisis.

Design/methodology/approach

A qualitative investigation was conducted drawing on a framework of imposed service innovation. Data were obtained from in-depth interviews with owners/managers of 20 SMEs in the hospitality and tourism sector in Chile.

Findings

Findings show that the effect of COVID-19 on SMEs includes a decline in demand due to lockdowns and restrictions, with minimal government support. Tourism and hospitality SMEs developed different service innovation strategies to confront the crisis, and several businesses were even able to exploit new opportunities for future growth.

Originality/value

The effect of COVID-19 and SMEs' service innovation strategies to confront a prolonged crisis is a topic that is largely unexplored, particularly in the tourism and hospitality sector. The findings contribute to the literature on emerging markets, crisis management and SME innovation in tourism and hospitality. The findings provide managerial implications for SME managers, governments and policymakers.
Disclosure of nonfinancial information in integrated reporting: the Brazilians professionals investors's perspective
Authors: Ribeiro Cíntia de Melo de Albuquerque , Cosenza José Paulo , Zotez Luís Perez , Vieira Neto Júlio
Published: October 2022

Purpose

This study aims to investigate the nonfinancial information related to capitals (intellectual, human, social and relationship, and natural) demanded by professional investors in their decision-making process, which can improve the usefulness of integrated reporting for this target audience.

Design/methodology/approach

A Systematic Literature Review in the Scopus, Web of Science and Google Scholar databases enabled the identification of information demanded by professional investors. This information was presented to experienced Brazilian investors participating in a focus group to align the theory on this topic with professional practice.

Findings

The results allow us to conclude that the focus group participants' perception is aligned with the international literature, both in the importance given to most of the nonfinancial information items identified and in the lack of interest in using integrated reporting in investment decisions. Nonetheless, the general perception of the focus group is not aligned with the literature procedures in terms of social and environmental information.

Research limitations/implications

A study with a larger scope and the adoption of other approaches can contribute to broaden the understanding of the perspectives of professional investors in Brazil, as well as in other regions.

Practical implications

The authors provide evidence that contributes to discussions about the information to be disclosed in integrated reports. Their results are useful to legislators, regulators, report preparers and investors.

Originality/value

The authors investigate the information demanded by professional investors in their decision-making process aiming to fill the literature gap relating the determinants of the integrated reporting disclosure and what is demanded by this target audience as a minimum content to be reported. As an additional result they offer interesting contributions to the literature providing reflections on nonfinancial information which have become important for Brazilian investors as from the COVID-19 pandemic.
How a chairperson's international experience can affect the post-entry speed of international SMEs from emerging economies: the roles of functional variety and power
Authors: Qin Linghua , Akhtar Naveed , Farooq Qamar , Gillani Syed Hussain Mustafa
Published: October 2022

Purpose

Previous research features the international experience of managers in the decisions regarding internationalisation speed. However, the vitality of the role a chairperson plays in shaping the internationalisation decisions of small and medium-sized enterprises (SMEs) from emerging economies is intriguing. Moreover, the decision-making process and leadership context of SME internationalisation are not fully understood. Drawing upon the upper echelons decision-making theory and the cognitive perspectives of decision, this paper examines the impact of a chairperson's previous experience on the post-entry speed of internationalisation, highlighting the conditioning effects of leadership contingencies – the functional variety and power of the chairperson.

Design/methodology/approach

The study uses a panel data set of Chinese SMEs active from 2010 to 2019 to test the research hypotheses. A feasible generalised least-squares estimator was applied to test the hypotheses.

Findings

The results show that the international experience of a chairperson speeds up the depth and breadth of the post-entry speed of internationalisation. However, the strength of these relationships depends on the leadership context. The chairperson's functional variety alleviates the influence of international experience, whilst the power of the chairperson reinforces its impact.

Originality/value

The results show that the international experience of a chairperson speeds up the depth and breadth of the post-entry speed of internationalisation. However, the strength of these relationships depends on the leadership context. The chairperson's functional variety alleviates the influence of international experience, whilst the power of the chairperson reinforces its impact.
The impact of global risks on supply chain performance. An empirical study on construction sector in the COVID-19 pandemic
Authors: Pham Hai Thanh , Truong Quang Huy , Sampaio Paulo , Carvalho Maria , Tran Duy Le Anh , Vo Vinh Xuan , Duong Binh An Thi
Published: October 2022

Purpose

This paper aims to identify and assess global risks in the supply chain performance.

Design/methodology/approach

First, global risks are identified and classified according to three criteria: content, probability and context. A set of supply chain performance indicators are then defined by the theory of resource-based view and balanced scorecard. Structural equation modeling is adopted to access risks in the global supply chain.

Findings

This article contributes to the supply chain risk management literature by providing a detailed operationalization of global supply chain risk constructs, e.g. natural disasters, war and terrorism, fire accidents, economic and political instability, social and cultural grievances, decease. Empirical results reveal that the supply chain is predominantly regarded as being vulnerable as the proposed model of risks can explain up to 12.6% variance of supplier performance, 25.2% innovation and learning, 23% internal business, 40.6% customer service and 32.4% finance.

Research limitations/implications

These risks are relevant contextual variables in strategic supply chain decisions. Supply chain managers should keep in mind acceptable cost/benefit tradeoffs in their firms' mitigation efforts associated with major contingency risks. This research advocates the allocation of scarce resources to adopt the supply chain strategies of avoidance, speculative and postponement.

Originality/value

The application of the strategic content/process/context to explain global supply chain performance is an interesting approach. Moreover, globalization trends and the COVID-19 perspectives are considered to be the main reasons for increasing such complex factors. Data on validating research models collected during the COVID-19 pandemic reflect the topicality of this study.
The role of universities in the inclusion of refugees in higher education and in society from the perspective of the SDGS
Authors: Finatto Carla Patricia , Aguiar Dutra Ana Regina , Gomes da Silva Camilla , Nunes Nei Antonio , Guerra José Baltazar Salgueirinho Osório de Andrade
Published: October 2022

Purpose

The purpose of this paper aims to discuss the outreach strategies of higher education institutions (HEIs) to promote the inclusion of refugees, focusing on two case studies of programs in southern Brazil.

Design/methodology/approach

This paper analyzes two outreach programs of Brazilian universities: the Welcome Program for Immigrants (Programa Acolhida ao Imigrante) of the University of South Santa Catarina, a private higher education institution and the Support Center for Immigrants and Refugees (Núcleo de Apoio ao Imigrantes e Refugiados), sponsored by the Federal University of Santa Catarina, a public university. The activities of the two institutions were compared with the targets of the sustainable development goals to discuss the outreach strategies of HEIs aimed at promoting the inclusion of refugees, through descriptive research, with a qualitative approach based on documentary and bibliographic research.

Findings

The results show that academic participation in research and outreach programs provides refugees with an education but also represents a social contribution far beyond qualifications and technical training, by mitigating local and global problems. The practice of inclusive education allows a reduction in historically existing inequalities. The findings of this study indicate that the results are much more effective when universities, government and society work together to reduce inequalities.

Originality/value

This study addressed how universities can and should ensure life quality (SDG 3), including an equitable education and fostering lifelong learning opportunities for everybody (SDG 4) and gender equality (SDG 5), to reduce unemployment (SDG 8) and inequalities among people (SDG 10), through outreach projects.
Flow characteristic analysis of a herringbone groove thrust bearing with shaft misalignment
Authors: Wang Jianping , Ran Haifeng , Dai Peng , Yan Shuping , Yao Xingjia , Wang Fengtao , Zuo Guizhong
Published: October 2022

Purpose

Herringbone groove thrust bearings are typically used in high-speed, light-load applications, such as spindle motors for hard disk drives. In the past researches, the effect of shaft misalignment was little considered. This study aims to reveal effects of shaft misalignment on the microscopic flow regime in the water-lubricated herringbone groove thrust bearing.

Design/methodology/approach

The liquid film in a thrust herringbone groove bearing was investigated by computational fluid dynamics. The effects of micro-grooves on the flow field were carefully explored. Two-dimensional liquid films at four different sites were examined for obtaining the rich flow field properties.

Findings

The distributions of pressure, temperature and water vapor volume fraction were obtained, the micro hydrodynamic effects were formed by the herringbone grooves and the effects of the shaft misalignment on lubrication and sealing performance could be found.

Originality/value

The influence of misalignment on the herringbone groove thrust bearing performance was investigated in detail. The obtained results could give the reference guideline for the bearing design.
Exploring the relationship between online review framing, pictorial image and review “coolness”
Authors: Fan-Osuala Onochie
Published: October 2022

Purpose

This study aims to investigate coolness – a hedonic attribute – in online consumer reviews (OCRs) by exploring the relationship between OCR framing, presence of pictorial images and OCR-perceived coolness. It also demonstrates how reviewers and brands can create or identify cool OCRs.

Design/methodology/approach

Two studies – one experimental and the other using archival data from an OCR platform – were used to test three hypotheses on the effect of OCR framing and pictorial images on perceived OCR coolness.

Findings

The results reveal that OCRs framed with negative words but reflecting positive views about products are perceived as cooler than OCRs framed with positive words and reflecting positive views. OCRs with pictorial images are perceived to be cooler than those without pictorial images.

Originality/value

Studies on coolness have focused on people and products but not message content. This research links a message’s framing and pictorial images to its perceived coolness in the OCR context. It provides practical suggestions to marketers, coolhunters and individuals interested in creating cool message content.
Motivations for supporting corporate social advocacy: applying the SIMCA model
Authors: Xiao Anli , Overton Holly K.
Published: October 2022

Purpose

This study examines why publics support corporate social advocacy (CSA) by looking at their support as a form of collective action that is motivated by individuals' shared group efficacy, anger and politicized identity by applying the Social Identity Model of Collective Action (SIMCA).

Design/methodology/approach

This study adopted an online survey (N = 273), sampling US adults who supported a company's CSA effort.

Findings

The survey found that shared group efficacy with the company led to higher intention to participate in CSA, engaging in positive word of mouth (PWOM) and providing financial support for the CSA cause. Individuals' identification with the company and the CSA cause also predicted intention to support CSA and PWOM. Sharing CSA cause-related anger with the company negatively predicted PWOM.

Originality/value

This study is original as it investigated why and how people support for a company's CSA initiative by applying the SIMCA model. It extends the applicability of the SIMCA model to explain support for CSA. Moreover, this study enriches our theoretical understanding of CSA as it provides implications for why publics support CSA and how corporations can play a central role in gaining publics' support while taking stances on controversial issues.
Beyond disclosure: the role of self-identity and context collapse in privacy management on identified social media for LGBTQ+ people
Authors: Yao Xinlin , Zhao Yuxiang Chris , Song Shijie , Wang Xiaolun
Published: October 2022

Purpose

While anonymous online interactions could be helpful and less risky, they are usually not enough for LGBTQ+ people to satisfy the need of expressing their marginalized identity to networks of known ties (i.e. on identified social media like Facebook, WeChat, and TikTok). However, identified social media bring LGBTQ+ people both sources and challenges like “context collapse” that flattens diverse networks or audiences that are originally separated. Previous studies focus on LGBTQ+ people's disclosure and responses to context collapse, few studies investigate how their perceptions of context collapse are shaped and their privacy management beyond regulating disclosure on social media. Drawing on identity theory and communication privacy management (CPM), this study aims to investigate how the need of LGBTQ+ people for self-identity affects their perceived context collapse and results in privacy management on identified social media.

Design/methodology/approach

Given the target population is LGBTQ+ people, The authors recruited participants through active LGBTQ+ online communities, influential LGBTQ+ activists, and the snowballing sampling. The authors empirically examined the proposed model using the PLS-SEM technique with a valid sample of 232 respondents concerning their identity practices and privacy management on WeChat, a typical and popular identified social media in China.

Findings

The results suggested that the need for expressing the self and the need for maintaining continuity of self-identity have significant influences on perceived context collapse, but vary in directions. The perceived context collapse will motivate LGBTQ+ individuals to engage in privacy management to readjust rules on ownership, access, and extension. However, only ownership management helps them regain the perceived privacy control on social media.

Originality/value

This study incorporated and highlighted the influence of LGBTQ+ identity in shaping context collapse and online privacy management. This study contributes to the literature on privacy and information communication and yields practical implications, especially on improving privacy-related interactive design for identified social media services.
Threshold effects of public debt on economic growth in South Africa: an application of a regression kink with an unknown threshold
Authors: Ndoricimpa Arcade
Published: October 2022

Purpose

South African public debt has recently increased significantly and has reached worrying levels. This study aims to examine the debt threshold effects on economic growth in South Africa, with an objective of suggesting a debt threshold as South African policymakers will seek to reduce debt to a sustainable level in the coming years.

Design/methodology/approach

The study applies a recent novel methodology advanced by Hansen (2017) that allows modelling a regression kink with an unknown threshold.

Findings

The findings of this study indicate a robust debt threshold of 37% of gross domestic product (GDP). Below this threshold, debt is growth-enhancing, but above 37% of GDP, debt is harmful to growth in South Africa.

Practical implications

Among other things, to reduce the debt-to-GDP ratio, South Africa will need a fiscal consolidation policy by undertaking reforms to state-owned companies to reduce their reliance on public funds, as well as putting in place economic measures to boost long-term growth. The country should also improve tax collection in order to realize additional tax revenue through enhancing compliance and other revenue collection measures.

Originality/value

Most of the existing studies on debt threshold effects in Africa are panel data studies, which assume parameter homogeneity, by determining a single debt threshold value applicable to all countries. This can be misleading as the debt-growth nexus is country-specific, being conditional on several factors, such as institutional quality. The present study applies a recent novel methodology, which allows to model a regression kink with an unknown threshold, for the case of South Africa. The methodology endogenously determines the debt threshold while also allowing a country-specific analysis.
Managing an ageing healthcare workforce: a systematic literature review
Authors: Kurashvili Mari , Reinhold Karin , Järvis Marina
Published: October 2022

Purpose

The aim of this paper is to review research conducted on managing the ageing healthcare workforce and identify gaps for further research.

Design/methodology/approach

A systematic literature search of studies in the English language was carried out in Scopus and Web of Science databases.

Findings

The study consists of an analysis of 75 published articles. The majority of the papers were published in recent years, indicating a growing interest in the field. The authors specified the following inclusion criteria: all years, articles/reviews, English language and full text in the Web of Science and Scopus databases. The authors of the paper illustrated seven major categories with different topics that were suggested for future research. It included: challenges of labor market in the healthcare field, age-related changes and their influence on work ability, training opportunities and lifelong learning among ageing health workforce, motives of early retirement, ageing and its relationship to Occupational Health and Safety. Longitudinal studies and case study strategy with mixed-methods approaches were suggested for future research by the authors.

Originality/value

The paper summarizes knowledge related to the management of ageing health workforce, describes topics researched and as a result, presents findings on and conclusions about the most important future implications of the ageing workforce for management in the healthcare field providing lines for further research. To the authors' knowledge, no holistic systematic literature reviews have been published in academic journals targeted specifically to ageing healthcare workers.
How organizations can benefit from entrainment: a systematic literature review
Authors: Sandra Danny , Segers Jesse , Giacalone Robert
Published: October 2022

Purpose

To provide ways of how organizations can benefit from entrainment, the purpose of this paper is to create a better theoretically grounded understanding of entrainment in organizations by reviewing the literature, describing managerial implications and identifying future research directions.

Design/methodology/approach

A systematic literature review of relevant literature based on peer-reviewed research papers published in highly ranked scientific journals.

Findings

It provides a clear understanding as to what constitutes entrainment in organizations and emphasizes its complexity. Further, six benefits of entrainment are highlighted, including the positive relationship between entrainment and organizational outcomes. The review may also provide entrepreneurs and practitioners a scientific basis for developing innovative tools to help managers’ foster entrainment in organizations.

Research limitations/implications

The review indicates that entrainment plays a much larger role in organizations than we think. Change leaders' actions may impact the emotions and actions of change recipients through entrainment. The selected keywords used in the search and the researcher's bias of including or excluding articles for this review are the major research limitations.

Originality/value

It is one of the first papers, to our knowledge, to provide a structured overview and understanding of the entrainment phenomenon in an organizational context, based on 41 peer-reviewed articles.