bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of genetic variants in a pedigree associated with epilepsy by using whole exome sequencing and whole genome sequencing
Authors: Zhang Qin-Qin , Wang Zi-Hua , Zhang Jun-Shi , Guo Jun-Nan , Lin Xu-Hong , An Lei
Published: July 2021

Epilepsy is a common heterogeneous group of neurological disorders including electroencephalographic and brain imaging. We used whole exome sequencing and whole genome sequencing to identify variants in a pedigree associated with epilepsy. Cranium CT scan showed that the lateral right parietal lobe was hyperdense, and there were no clear boundaries with brain tissue in affected cases. Using WES, one exclusive nonsynonymous mutant in gene TSC2 (Chr16:2138307; c.5240 T > G; p.Ile1747Ser) was involved in this disease. Further analysis showed that de novo variant in TSC2 was high conserved across different species. Moreover, the two affected sisters and their father had the same compound heterozygous variants in TSC2, while the father had no epilepsy but depigmentation. These variants demonstrated that variant in TSC2 may result in epilepsy with incomplete penetrance in humans, and the CNV and SV variants we identified probably be involved in this disease.
An increase in neutrophil-to-lymphocyte ratio predicts poor functional outcomes in older patients with acute ischemic stroke: a retrospective study
Authors: Xue Jie , Zhang Xiao-Guang , Jiang Hua-Yu , Cui Xian-Kai , Zhang Dong , Yao Zhi-Wen , Yue Yun-Hua
Published: July 2021

The neutrophil-to-lymphocyte ratio has emerged as a predictor of functional outcome in stroke patients. However, less is known about the value of neutrophil to lymphocyte ratio in older patients. This clinical study evaluated whether the neutrophil-to-lymphocyte ratio is associated with stroke severity and early clinical outcomes in older patients with acute ischemic stroke. This observational study included acute ischemic stroke patients aged 80 years or older. The patients were divided into three groups, and information was collected, including demographic, clinical and laboratory data. The neutrophil associations to lymphocyte ratio with stroke severity and early clinical outcomes were assessed with logistic regression. Overall, 356 older patients were enrolled in this study, with a median age of 85.0 (82.0–88.0). Split by tertiles of neutrophil-to-lymphocyte ratio, 118 patients were in the bottom tertile (<2.17), 118 patients were in the middle tertile (2.17–3.36), and 120 patients were in the top tertile (>3.36). After multivariable analysis, patients in the highest tertile were likely to have moderate to severe stroke on admission (OR 4.87, 95% CI, 1.93–12.30, P = 0.001), higher risks of primary unfavorable outcome (OR 2.70, 95% CI, 1.09–6.69, P = 0.032) and secondary unfavorable outcome (OR 2.00, 95% CI, 1.00–4.00, P = 0.050) compared to the lowest tertile. Our finding demonstrated that the neutrophil-to-lymphocyte ratio is an independent predictor of stroke severity and early clinical outcomes in older patients with acute ischemic stroke.
Prevalence of restless leg syndrome in Mongolian adults: Mon-TimeLine study
Authors: Davaadorj Anujin , Byambajav Puntsagdulam , Munkhsukh Munkh-Undral , Och Maralgua , Zorigt Sevjid , Boldbaatar Damdindorj , Jadamba Tsolmon , Byambasukh Oyuntugs , Dagvajantsan Byambasuren
Published: July 2021

We conducted an epidemiologic study based on survey neuroscience screening for restless leg syndrome in the Mongolian to determine the prevalence of restless leg syndrome. We used baseline data from the Mon-TimeLine study, a multidisciplinary, prospective, population-based cohort study. The total number of participants (n = 1572) ranged from 18 to 65 years of age. We found the prevalence of restless leg syndrome to be 6.6% (n = 103), among which 4.1% (n = 16) were males and 7.3% (n = 87) were females. The peak prevalence age for both genders was 45–55, and we found a positive correlation with body mass index (P < 0.05). Most cases were mild (44.7%) or moderate (35.9%), but 18.4% and 1% of the cases were severe or very severe, respectively. The severe groups showed a positive association with chronic kidney disease, as well as with gastritis. In conclusion, the prevalence of restless leg syndrome in Mongolia approximates that in other countries.
Meningioma genomics: a therapeutic challenge for clinicians
Authors: Moussalem Charbel , Massaad Elie , Minassian Georges B. , Ftouni Louna , Bsat Shadi , Houshiemy Mohamad N. El , Alomari Safwan , Sarieddine Rana , Kobeissy Firas , Omeis Ibrahim
Published: July 2021

Meningiomas are amongst the most commonly encountered intracranial tumors. The majority of these tumors arise intracranially, and the remaining incidents occur along the spinal cord. Meningiomas tend to grow gradually, with many tumors arising in inaccessible locations. Such sporadic behavior poses a therapeutic challenge to clinicians, causing incomplete tumor resections that often lead to recurrence. Therefore, ongoing research seeks to find alternative systematic treatments for meningiomas, with gene-based therapeutics of high interest. Subsequently, genetic studies characterized frequent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA. These genes are communally exhibited in 80% of sporadic meningiomas. In addition, other genes such as the DUSP family, the NR4 family, CMKOR, and FOSL2, have been identified as key players in spinal meningiomas. In this perspective, we aim to investigate current genetic-based studies, with the ongoing research mainly focused on the above NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA genes and their involved pathways. In addition, this perspective can serve as a potential cornerstone for future genetic analyses of meningioma cases.
Clinical tips in diagnosing idiopathic normal pressure hydrocephalus: a new concept beyond the cerebrospinal fluid tap test
Authors: Lee Seon-Min , Kwon Kyum-Yil
Published: July 2021

Accurate diagnosis of idiopathic normal pressure hydrocephalus is important to manage patients with idiopathic normal pressure hydrocephalus more appropriately. Based on the clinical features and brain magnetic resonance imaging findings, the idiopathic normal pressure hydrocephalus diagnosis is made up. However, most clinicians do not recommend the shunt operation to their patients with presumed idiopathic normal pressure hydrocephalus unless any patients with idiopathic normal pressure hydrocephalus show a considerable improvement through the cerebrospinal fluid tap test. The cerebrospinal fluid tap test is an invasive method and has some limitations to diagnose idiopathic normal pressure hydrocephalus. Therefore, we suppose that a new diagnostic approach of idiopathic normal pressure hydrocephalus is necessary. Various magnetic resonance imaging findings suggesting idiopathic normal pressure hydrocephalus have been applied to diagnose idiopathic normal pressure hydrocephalus. Besides, advances in neuroimaging techniques, including dopamine transporter imaging, and amyloid imaging may allow clinicians to exclude the potential misdiagnosis including Parkinsonian disorders and Alzheimer’s disease in patients with presumed idiopathic normal pressure hydrocephalus. Herein, we suggest a neuroimaging-supportive algorithm for the diagnosis of idiopathic normal pressure hydrocephalus. We suspect that this is the time to change the classical approach of diagnosing idiopathic normal pressure hydrocephalus.
Clinical utility of degradomics as predictors of complications and clinical outcome in aneurysmal subarachnoid hemorrhage
Authors: Bsat Shadi , Chanbour Hani , Bsat Ayman , Alomari Safwan , Moussalem Charbel , Houshiemy Mohamad Nabih El , Omeis Ibrahim
Published: July 2021

Most of the debilitating conditions following aneurysmal subarachnoid hemorrhage result from symptomatic cerebral vasospasm and delayed cerebral ischemia. Several scales are being used, but they still lack objectivity and fail to quantify complications considered essential for prognostication routine use of biomarkers to predict complications and outcomes after aneurysmal rupture is still experimental. Degradomics were studied extensively in traumatic brain injury, but there is no discussion of these biomarkers related to aneurysmal subarachnoid hemorrhage. Degradomics involve the activation of proteases that target specific substrates and generate specific protein fragments called degradomes. While the proteolytic activities constitute the pillar of development, growth, and regeneration of tissues, dysregulated proteolysis resulting from pathological conditions like aneurysmal subarachnoid hemorrhage ends up in apoptotic processes and necrosis. To our knowledge, this is the first overview that lists a panel of degradomics with cut-off values in serum and cerebrospinal fluid, where specificity and sensitivity are only found in Kallikrein 6, Ubiquitin C Terminal Hydrolase 1 and Alpha-II-Spectrin.
Surgical treatment of metastatic pheochromocytomas of the spine: a systematic review
Authors: Visani Jacopo , Mongardi Lorenzo , Cultrera Francesco , Bonis Pasquale De , Lofrese Giorgio , Ricciardi Luca , Scerrati Alba
Published: July 2021

Metastatic pheochromocytoma of the spine (MPS) represents an extremely rare and challenging entity. While retrospective studies and case series make the body of the current literature and case reports, no systematic reviews have been conducted so far. This systematic review aims to perform a systematic review of the literature on this topic to clarify the status of the art regarding the surgical management of MPS. A systematic review according to PRISMA criteria has been performed, including all studies written in English and involving human participants. 15 papers for a total of 44 patients were finally included in the analysis. The median follow-up was 26.6 months. The most common localization was the thoracic spine (54%). In 30 out of 44 patients (68%), preoperative medications were administered. Open surgery was performed as the first step in 37 cases (84%). Neoadjuvant treatments, including preoperative embolization were reported in 18 (41%) cases, while adjuvant treatments were administered in 23 (52%) patients. Among those patients who underwent primary aggressive tumor removal and instrumentation, 16 out of 25 patients (64%) showed stable disease with no progression at the final follow-up. However, the outcome was not reported in 14 patients. Gross total resection of the tumor and spinal reconstruction appear to offer good long-term outcomes in selected patients. Preoperative alpha-blockers and embolization appear to be useful to enhance hemodynamic stability, avoiding potential detrimental complications.
On clinical findings of Bickerstaff’s brainstem encephalitis in childhood
Authors: Messina Giulia , Sciuto Sarah , Fontana Alessandra , Greco Filippo , Oliva Claudia F. , Pappalardo Maria Grazia , Sapuppo Annamaria , Smilari Pierluigi , Pavone Piero , Foti Rosario
Published: July 2021

A short review on the clinical presentation of pediatrics cases of Bickerstaff brain encephalitis emphasizing the broad clinical spectrum of the disease. Cases of pediatric Bickerstaff’s brainstem encephalitis collected on three electronic medical databases (PubMed, Cochrane Library and Scopus Web of Science) are reviewed. The inclusion criteria of the cases were based on the clinical characteristics of the disorder in the pediatric age. We reviewed 20 articles on Bickerstaff’s brainstem encephalitis, identifying 40 pediatric cases focused on the clinical symptoms. We saw that the prevalence was higher in male subjects, and the median age at diagnosis was 8 years. The phenotype of pediatrics patients was similar to previously published literature. We identify three cases of overlapping forms between Bickerstaff brain encephalitis and Guillain-Barré Syndrome in patients with lower limbs weakness and typical signs of Bickerstaff brain encephalitis, suggesting a combined involvement of the central and peripheral nervous system. Although there is no defined data on incidence and prevalence in the literature, Bickerstaff’s brainstem encephalitis appears to be a rare disorder, especially in children. The incidence of Bickerstaff brain encephalitis and Guillain-Barré Syndrome, and Miller Fisher Syndrome has been underrated in the past, primarily due to an underestimation of the forms with a Peripheral Nervous System involvement. Bickerstaff brain encephalitis usually has a rapid and acute onset within 2–4 weeks, characterized by a typical picture of ophthalmoplegia, hyperreflexia, cerebellar symptoms as ataxia. The subsequent manifestations of hyperreflexia or consciousness disturbances as drowsiness, sleepiness, or coma, indicative of central involvement, suggest a Bickerstaff brain encephalitis clinical diagnosis.
Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease
Authors: Zhang Yuqi , Lu Kangrong
Published: July 2021

Astrocytes are the most abundant glia in the central nervous system that play a significant role in disease. Recently, it roles of synaptic plasticity in neuropathological damages have been questioned whether the structural and functional plasticity of synapses contributes to the pathogenesis of Parkinson’s disease. The regulation of synaptic plasticity by astrocytes has also been widely researched based on astrocytes regulate synaptic plasticity by releasing Adenosine triphosphate, glutamate, and D-serine. We discuss the possible role of astrocytes in the regulation of synaptic plasticity, which may provide a new direction to Parkinson’s disease treatment.
Thrombotic risk in patients with COVID-19
Authors: Pancaldi Edoardo , Pascariello Greta , Cimino Giuliana , Cersosimo Angelica , Amore Ludovica , Alghisi Fabio , Bernardi Nicola , Calvi Emiliano , Lombardi Carlo Mario , Vizzardi Enrico , Metra Marco
Published: July 2021

Emerging evidences prove that the ongoing pandemic of coronavirus disease 2019 (COVID-19) is strictly linked to coagulopathy even if pneumonia appears as the major clinical manifestation. The exact incidence of thromboembolic events is largely unknown, so that a relative significant number of studies have been performed in order to explore thrombotic risk in COVID-19 patients. Cytokine storm, mediated by pro-inflammatory interleukins, tumor necrosis factor α and elevated acute phase reactants, is primarily responsible for COVID-19-associated hypercoagulopathy. Also comorbidities, promoting endothelial dysfunction, contribute to a higher thromboembolic risk. In this review we aim to investigate epidemiology and clarify the pathophysiological pathways underlying hypercoagulability in COVID-19 patients, providing indications on the prevention of thromboembolic events in COVID-19. Furthermore we aim to reassume the pathophysiological paths involved in COVID-19 infection.
Revisiting pulmonary rehabilitation during COVID-19 pandemic: a narrative review
Authors: Dixit Snehil , Borghi-Silva Audrey , Bairapareddy Kalyana Chakravarthy
Published: July 2021

There has been an apparent association between the risks of complications with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with a history of existing chronic respiratory diseases during the pandemic of coronavirus disease 2019 (COVID-19). SARS-CoV-2 poses a severe risk in cardiopulmonary management. Moreover, chronic respiratory diseases may further amplify the risk of morbidity and mortality among the afflicted population in the pandemic era. The present review outlines the importance of pulmonary rehabilitation (PR) in persons with chronic respiratory diseases (Chronic obstructive pulmonary disease (COPD) and Asthma) during the COVID-19 era. In this context, amongst the population with a pre-existing pulmonary diagnosis who have contracted SARS-CoV-2, following initial medical management and acute recovery, exercise-based pulmonary rehabilitation (PR) may play a crucial role in long-term management and recovery. The energy conservation techniques will play a pragmatic role in PR of mild to moderate severity cases to counter post-COVID-19 fatigue. Moreover, there is also an urgent need to effectively address post-COVID-19 anxiety and depression, affecting the PR delivery system.
Determinants of atrial fibrillation after cardiac surgery
Authors: Qureshi Mashal , Ahmed Ammaarah , Massie Victoria , Marshall Ellenor , Harky Amer
Published: July 2021

Post-operative Atrial fibrillation (POAF) is a common complication post cardiac surgery. It can result in detrimental short- and long-term outcomes due to the increased risk of stroke, cardiac arrest and congestive heart failure in addition to prolonged intensive care and total hospital stay raising the overall healthcare cost. Accurately identifying predictors and biomarkers for POAF ensures that patients at greatest risk can be given the appropriate prophylactic measures; resources can be distributed to the groups who are most in need and where they will gain the optimum effect. Commonly recurring predictors can be investigated further to unveil the pathophysiology behind POAF, which has yet to be fully understood. This literature review aims to examine relevant studies on the proposed predictors of POAF: increased age, gender, history of atrial fibrillation, hypertension, cardiopulmonary bypass time and the use of beta blockers amongst others. This paper will discuss the significance of both the well-known and newfound risk factors to consolidate the areas that require further exploration in order to highlight those at risk and to unravel the mechanism behind POAF.
Atrioventricular synchronous leadless pacemaker: state of art and broadened indications
Authors: Mitacchione Gianfranco , Schiavone Marco , Gasperetti Alessio , Viecca Maurizio , Curnis Antonio , Forleo Giovanni B.
Published: July 2021

Leadless pacemakers (LLPMs) have become a major breakthrough in the management of bradyarrhythmia as an attractive alternative to the standard transvenous pacemakers (TV-PMs). Recently, the introduction of a second-generation LLPMs (Micra AV-MC1AVR1) has expanded pacing modes to obtain atrioventricular (AV) synchronous pacing, providing an interesting alternative in the actual scenario of leadless pacing. Nevertheless, actual reports have highlighted some concerns regarding those devices. In this review, we sought to provide an overview of this technology based on its approval studies and major reports.
Prognostic implications of atrial fibrillation in patients with stable coronary artery disease: a systematic review and meta-analysis of adjusted observational studies
Authors: Saglietto Andrea , Varbella Vittorio , Ballatore Andrea , Xhakupi Henri , Ferrari Gaetano Maria De , Anselmino Matteo
Published: July 2021

Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. Despite the frequent coexistence with coronary artery disease (CAD), the prognostic independent implication of AF in patients with stable CAD remains controversial. Our aim was to perform a pairwise meta-analysis of adjusted observational studies comparing cardiovascular outcomes in patients with stable CAD with and without concomitant AF, in search of AF-specific prognostic implications. We performed random effect meta-analysis of binary outcome events in studies comparing stable CAD patients with versus without AF providing risk estimates adjusted for confounding variables. Literature search was performed in PubMed/MEDLINE and Google Scholar. Death was the primary endpoint of the analysis, while myocardial infarction, coronary revascularization and stroke secondary endpoints. 5 studies were included in the meta-analysis, encompassing a total of 30230 stable CAD patients (2844 with AF, 27386 without AF). Stable CAD patients with AF presented an independent increased risk of death (HR 1.39, 95% CI: 1.17–1.66) and stroke (HR 1.88, 95% CI: 1.45–2.45) compared to those without AF. Instead, risk of myocardial infarction (HR 0.90, 95% CI: 0.66–1.22) and coronary revascularization (HR 0.96, 95% CI: 0.79–1.16) did not differ in stable CAD patients with and without the arrhythmia. In patients with stable CAD, AF exerts an independent negative prognostic effect, increasing the risk of death and stroke. However, the small number of eligible studies included in this analysis highlights the astonishing lack of data regarding prognostic implications of concomitant AF in patients with stable CAD.
Long term prognostic benefit of complete revascularization in elderly presenting with NSTEMI: real world evidence
Authors: Agra-Bermejo Rosa , Cordero Alberto , Veloso Pedro Rigueiro , Álvarez Diego Iglesias , Álvarez Belen Álvarez , Díaz Brais , Rodríguez Leyre Alvarez , Abou-Jokh Charigan , Álvarez Belén Cid , González-Juanatey Jose R. , Acuña Jose M García
Published: July 2021

The benefit of complete revascularization in elderly patients with non-ST elevation myocardial infarction (NSTEMI), and multivessel disease remains debated (MVD). The aim of our study was to determine the current long-term prognostic benefit of complete revascularization in this population. A retrospective cohort study of 1722 consecutive elderly NSTEMI patients was performed. Among the study participants 30.4% (n = 524) were completed revascularizated and in 69.6% (n = 1198) culprit vessel only revascularization was performed. A propensity score analysis was performed and we divided the study population into two groups: complete revascularization (n = 500) and culprit vessel only revascularization (n = 500). The median follow-up was 45.7 months, the all cause mortality (44.5% vs 30.5%, p < 0.001) (HR 0.74 (0.57–0.97); p = 0.035) and cardiovascular mortality (32.6% vs 17.4%, p < 0.001) (HR = 0.67 (0.47–0.94); p = 0.021) were significantly lower in patients with complete revascularization. In our study, we observed a long-term benefit of complete revascularization in elderly NSTEMI and MVD patients. Elderly patients should also be managed according to current guidelines to improve their long-term prognosis.
Independent predictors of in-hospital and 1-year mortality rates in octogenarians with acute myocardial infarction
Authors: Căruntu Florina , Bordejevic Diana Aurora , Buz Bogdan , Gheorghiu Alexandru , Tomescu Mirela Cleopatra
Published: July 2021

Older age is known as a negative prognostic parameter in acute myocardial infarction (AMI) patients. In this study, we aimed to explore age-associated differences in treatment protocols, in-hospital and 1-year mortality. This cohort observational study included 277 consecutive AMI patients, separated into 2 groups according to whether their age was ≥80 years or not. We found that group I patients (aged ≥80 years) had a notably lower rate of percutaneous coronary intervention (PCI) performed (P < 0.0001) and a notably higher in-hospital death rate (P < 0.003). The multivariate logistic regression analysis found that three variables were independent predictors of in-hospital mortality: age ≥80 years (P < 0.0001), LVEF <40% (P < 0.0001), and Killip class ≥3 (P < 0.0001). The 1-year death rate was again significantly higher in group I patients (P < 0.001) and was independently predicted by the triple-vessel coronary artery disease (P = 0.004) and an LVEF <40% at admission (P = 0.001). The 1-year readmission rate was superior in group I (P < 0.01) and independently predicted by an age ≥80 years (P < 0.001), and an history of congestive heart failure (P < 0.0001) or permanent atrial fibrillation (P < 0.001). We concluded that patients aged ≥80 benefit less often from a PCI and have higher rates of in-hospital mortality, as well as of 1-year readmission and mortality rates.
Expression of toll like receptors before and after coronary angiography with isomolar contrast among those with and without coronary atherosclerosis
Authors: Zare Lida , Eidi Akram , Safarian Mohammad , Arababadi Mohammad Kazemi
Published: July 2021

Angiography is a safe technique for the detection of and treatment of cardiovascular diseases. However, the effects of the technique on the molecular response of the immune system are yet to be clarified. Toll like receptors (TLRs) are the important molecule participate in the innate immunity responses and induction of inflammation. This project was designed to explore the effects of angiography on the expression of TLR1, TLR2, TLR3 and TLR4. Fifty-five participants, including three separate groups (without artery stenosis, with one artery stenosis and more than one artery stenosis), were assessed in this project. TLR1, TLR2, TLR3 and TLR4 expression levels were evaluated in peripheral blood immune cells by measuring mRNA before and after angiography using Real-Time PCR techniques. mRNA levels of TLR1, TLR2 and TLR3 were significantly increased following angiography. Expression of TLR4 did not change after angiography. Other criteria also showed no correlation on TLR expression after angiography. TLR4 mRNA levels had a positive correlation with age in the participants without artery stenosis. Angiography may induce inflammation in subjects without artery stenosis via up-regulation of TLR1, 2 and 3 which may lead to cardiovascular diseases related complications.
Paradox of Presence
Authors: Maksymchuk Anastasiya
Published: July 2021

The following work is an autoethnographic study on emotional engagement and sense of presence mediated by Internet in cases of extreme situations. This story is the one of death. In April 2020, my step-father died of lung cancer. The COVID-19 lockdown had caught him and my mother in Berlin, where my step-father had been undergoing his treatment which unfortunately turned out to be unsuccessful. Based in Lisbon, I was not able to be physically next to my parents during these hard times. However, I tried to do my best giving support via messages and videocalls. It coincided that on the night of my step-father's death, when my mother was next to him in the hospital room, I was also there, “next” to them both, but via videocall. My short film is a creative reflection on the concept of mediated presence.
Ever-Lockdown: Waiting through Times of Playbour and Pandemic in Animal Crossing
Authors: Seller Merlin
Published: July 2021

Animal Crossing: New Horizons’ (Nintendo 2020) huge popularity has previously been attributed to escapism prompted by the singularity of lockdown life (Frushtick 2020; Zhu 2020), resonating with analyses which have been quick to frame lockdown as a radical historical caesura in experiences of work and leisure (Harari 2020; Krastev 2020). However, Adam Chmielewski and Fernanda Bruno argue that lockdown can be seen in relation to continuities in neoliberalism’s alienation, isolation and hyperconnected domestic digital labour (2020; 2020) - a condition of prolonged and displaced anxiety I term ‘ever-lockdown’ - necessitating a more nuanced account of Animal Crossing’s ambivalent mix of busywork and relaxation. Rather than escapist utopia, consumerist dystopia (Chang 2019), or softened capitalism (Bogost 2020), I will consider Animal-Crossing as providing absorbing boredom in which intense interactivity can be interpassively (Pfaller, 2017) withheld in a time of demanding and destabilising crises, facilitating a subtle, affective sense of place amidst the ‘ever-lockdown.’
Transient Feelings
Authors: Xu Donnalyn
Published: July 2021

In response to the shifts of communication following the COVID-19 lockdown restrictions, this research investigates the disorienting experience of navigating loneliness and intimacy in the digital space. Creative writing is a relatively unexplored but recently emerging field of academic inquiry (Skains 2018, 84). Poetry in particular involves research into the language and textures of the world—it is a critical way of thinking that incorporates not just the signified meaning of words, but also the phonaesthetics, placement, space, and textual structure. This practice-based creative work is presented in the form of a 9-part autoethnographic prose poem that echoes the fragmented and asynchronous nature of digital communication (Bonner 2016, 11). Through stream-of-consciousness vignettes that could be read in any order, I emulate the experience of scrolling through a feed. I explore ideas of limitlessness in the face of apocalyptic endings, where our desire for more is troubled by having too much. This experimental and experiential paper is ultimately an interrogation of the tension between affective relations and isolation, where mediated bodies are troubled by longing, loneliness, and looking.
A Historical and Philological Commentary on Genesis 1:1–3
Authors:   National Pedagogical Dragomanov University, Dobrydnik Nadiia
Published: July 2021

The article examines phonetic, lexical, grammatical and mor-phological devices employed in Gen 1:1–3 in the light of the literary tra-ditions of the Middle East, in particular that of ancient Mesopotamia.
Interpretations of the Aggadah in the Commentaries of the Maharal of Prague, the Gaon of Vilna and R. Nachman of Bratslav
Authors:   Hebrew University of Jerusalem, Kasparova Natalia
Published: July 2021

This article examines three commentaries on the Aggadah story of the Talmudic sage Rabbah bar bar Hana’s incredible journeys: by the Maharal of Prague (16th cent.), the Gaon of Vilna (18th cent.) and Rabbi Nachman of Bratslav (end 18th – 19th cent.) While all three authors see the story in an allegorical vein, each one has their own focus and seems to wander away from the text proper and interpret it through the lens of their own set of ideas, be it philosophy, metaphysics, ethics, asceticism or mysticism. So Maharal of Prague sees the Haggadah as kind of philosophical and mystical treatise. He hints to the reader that this Haggadah contains the secrets of metaphysics and Kabbalah. For the Vilna Gaon the story has an ethical message. He sees the crow as talmid haham whose face is black from malnutrition and studying the Torah at night. Rabbi Nachman is the most exalted and ecstatic scholar of all three. He uses the interpretation of Haggadah as part of his mystical lessons. The topic of his lesson is Messianic Deliverance.
The Divine-Human Unity in the Context of the Hasidic Doctrine of the Tsaddik’s Power
Authors:   I.F.Kuras Institute of Political and Ethnic Studies, National Academy ofSciences of Ukraine, Turov Igor
Published: July 2021

For the founders of Hasidism, its fundamental principle is a spiritual practice that ensures an unceasing connection between the believer and his Creator. This doctrine is not purely theological: it serves as a rationale behind the societal hierarchy proposed by the Hasidim. The leader, having achieved the highest point of unity with the Lord, sets a pattern to be followed by the community members in their relationship with him as the one who rules over them, thus justifying the all-encompassing power of the Tsaddiks. The paper discusses three basic concepts of God-man unity. The essence of the first is the perception of the believer as immersing himself in the deity and dissolving there like a water drop in an ocean. The other two envision the unity as a peculiar interpersonal communication. The paper argues that within the Hasidic doctrine all three concepts are on an equal footing and shows the principles of their coexistence.
The Oldest Ashkenazi Gravestone from Ostróg (1520) and Its Destruction
Authors:   University of Wisconsin, Nosonovsky Miсhael , Fishel Alexandra ,   Institute of Oriental Manuscripts, Russian Academy of Sciences
Published: July 2021

The article reviews the history of the Jewish cemetery in Os-tróg, Ukraine, – one of the oldest Jewish cemeteries in Eastern Europe: from the earliest dated gravestones of 1445 and 1520, to the visit of Jew-ish ethnographers S. An-sky and S. Yudovin in 1912, to its destruction in 1968, and to the recent efforts of the local activist H. Arshinov to identify and restore several hundreds of the gravestones.
Jacob Brafman’s The Book of the Kahal: the Jew Who Was Afraid of Jewishness
Authors:   State University of Social Studies and Humanities, Prokhorov George
Published: July 2021

The article discusses the narrative structure and rhetorical devices of The Book of the Kahal (1869)– an influential pamphlet by the baptized Jew Jacob Brafman. The book breathes conspiracy theories and portrays the Jews as a state within a state governed by the Kahal and regulated by the Talmud, even when they try to pass themselves as a confession to fool gullible Christians. In line with the traditions of collaboration literature, the author, obsessed with the glorious Imperial might and full of disdain for all things Jewish, demands that the Jews abandon their treacherous “multifaceted” identity in favor of Russia.
The Role of Religion in Shaping Ethnic Identity in Jewish Children of Contemporary Russia
Authors:   Russian State University for the Humanities, Davydova Marina
Published: July 2021

It is commonly believed that for the majority of the Soviet-raised Russian Jews, Judaism and its practices have not played a significant part in shaping their Jewish identity. For today’s Russian Jewish children, however, the personal development is mainly defined by their families, so the religious education and practical observance of Jewish rites and customs form the very basis for their identity. Studying the specifics of this mechanism in Russian Jewish children also reveals a correlation between the parents’ religious views and their determination to raise their offspring within the Jewish tradition.
The Jewish Secular NGOs of Krasnodar: The Past and the Present
Authors:   St.Petersburg State University, Padalko Semyon
Published: July 2021

Thе paper reviews the history of two Jewish secular non-profit organizations in Krasnodar: the Cultural Center “Shalom” and the Charitable Fund “Hesed.” Founded amidst the social and economic hardships of the 1990s, they helped consolidate the local Jews into a community, fulfilling a number of functions, from cultural education and administering to the needs of the less fortunate to cooperation with the city and the Jewish religious community of Krasnodar.
A short review on different techniques used for site selection of air quality monitoring stations
Authors:   Department of Civil Engineering, National Institute of Technology Agartala, Agartala - 799046, India, Kollati Hemanth , Debnath Animesh ,   Department of Civil Engineering, National Institute of Technology Agartala, Agartala - 799046, India
Published: July 2021

Air pollution has become a serious concern across the world in the last few decades. In specific cities, the air quality index value had changed from very unhealthy to a hazardous level of health concern. Air pollution has a serious impact on daily lives in those cities. Monitoring of air pollution is becoming necessary these days. Air quality monitoring stations are installed to get the air pollution data, which indicates in the air quality index (AQI) value. In order to contain a proper air quality index (AQI) value, it is essential to locate the air quality monitoring stations in the appropriate place of the study area. Several techniques were being used for site selection of air quality monitoring stations for the last few decades. In this short review, all such techniques have been studied systematically, and comprehensive analysis has been reported for further use by the scientific community and policymakers. In this study, the methods used in the site selection of air quality monitoring stations were categorized into four groups. (1) Multi-Criteria Decision Making (MCDM) techniques; (2) Geographical Information System (GIS); (3) hybrid techniques; and (4) miscellaneous. In the site selection of air quality monitoring stations, the decision-makers should consider various parameters based on the study area. While considering various parameters, the problem solving becomes complex. At this point, MCDM techniques, GIS, and Hybrid techniques are found to be helpful tools for the decision-makers.
TUGAS JURNAL ACHMAD MUBARAK
Authors: Mubarak Achmad
Published: July 2021

Menjadi seorang pemimpin ,tentunya harus memiliki jiwa kepemimpinan, memiliki rasa nasionalisme,tidak memaksakan kehendak pribadi, tidak mengkhianati rakyat nya sendiri, tidak mendiskriminasi suatu keberagaman minoritas tubuh.
Analysis of Disaster Awareness Perception Levels of Students in Social Studies Teaching Undergraduate Program
Authors: Türksever Ömer
Published: July 2021

Disasters are known as calamities affecting all humanity on earth and have adverse impacts on human life in various ways. Although many natural disasters cannot be prevented, their adverse effects on people can be mitigated. It is important to raise the awareness of people about disasters, whether they are caused by human effects or nature. Disaster education plays an important role in raising this awareness. The study group of the study consists of 172 teacher candidates receiving education in the 1st, 2nd, 3rd and 4th grades of the department of social studies teaching in a state university located in the Central Anatolia region. In order to measure the disaster awareness of the teacher candidates, the scanning pattern included under the quantitative study method has been used. T-test and ANOVA has been utilized in the analysis of disaster awareness perception scale. As the result of the analysis; in the sub-dimensions of disaster education awareness, pre-disaster awareness, false disaster awareness and post-disaster awareness, the teacher candidates have been evaluated according to their gender, their general academic average scores, their participation in a conference or a panel and according to their homework, presentation or project preparing status. Based on the results of the research, in order for the teacher candidates to gain the right disaster awareness, it has been recommended that they should be provided with disaster awareness courses in their undergraduate curriculum, that they should take part in various research projects, and attend various symposiums, congresses related with disaster awareness.
TUGAS JURNAL NURWAHIDIN
Authors: Wahidin Nur
Published: July 2021

Negara wajib untuk memenuhi serta melindungi hak warga negaranya, termasuk hak atas status kewarganegaraan. Status tersebut akan mempermudah warga negara dalam menjalani kehidupannya, baik di negara yang memberikannya status kewarganegaraan maupun di negara lain. Tingginya mobilitas warga negara berakibat pada sekat antar negara tidak lagi terbatas jarak dan waktu. Akibatnya, status kewarganegaraan seseorang dapat berubah, baik karena kebutuhan pribadi atau kewajiban negara kedua yang mengharuskan warga negara untuk memiliki status kewarganegaraan negara tersebut. Permasalahan dalam penelitian ini adalah sejauh mana kewarganegaraan ganda dalam perspektif HAM dapat mewujudkan suatu sistem kesejahteraan?.Penelitian ini merupakan penelitian normatif dengan menggunakan pendekatan perundang-undangan, pendekatan sejarah serta pendekatan kasus. Hasil penelitian menunjukkan bahwa jaminan terhadap hak atas status kewarganegaraan merupakan bagian yang tidak dapat terpisahkan dari konsepsi hak asasi manusia yang tertuang dalam konstitusi UUD NRI 1945. Akan tetapi, dengan pesatnya arus perkembangan global menyebabkan akomodasi kewarganegaraan ganda dalam hukum kewarganegaraan Indonesia merupakan hal yang dapat diterapkan untuk kedepannya. Adanya pengakuan terhadap kewarganegaraan ganda dapat dipandang sebagai bagian dari upaya negara untuk mewujudkan kesejahteraan bagi seluruh warga negara dan melindungi hak asasi warga negara terhadap status kewarganegaraannya.
JURNAL HUKUM TATA NEGARA 10200120198
Authors: Magfira.A Nur Amalia
Published: July 2021

Pelembagaan kedaulatan rakyat dilakukan melalui perwakilan tidak langsung oleh wakilwakil rakyat yang dipilih melalui proses pemilihan umum. Proses pemilihan umum merupakan suatu usaha untuk melembagakan demokrasi agar dapat berjalan baik secara prosedural maupun substansial. Pada dasarnya pemilihan umum mempunyai empat tujuan menurut Jimly Asshiddiqie, yaitu : (a) untuk memungkinkan terjadinya rotasi peralihan kepemimpinan pemerintahan secara tertib dan damai; (b) untuk memungkinkan terjadinya pergantian pejabat yang akan mewakili kepentingan rakyat di lembaga perwakilan; (c) untuk memungkinkan terjadinya pergantian pejabat yang akan mewakili kepentingan rakyat di lembaga perwakilan; dan (d) untuk melaksanakan prinsip hak-hak asasi warga negara (Jimly Asshidiqie, 2009: 418-419).
PENGARUH PEMBERDAYAAN LEMBAGA PERKREDITAN DAN SUMBER PENDANAAN TERHADAP MANAJEMEN STRATEGI USAHA MIKRO KECIL MENENGAH (UMKM) DI KOTA BANDAR LAMPUNG
Authors: Fajri Ratu Chaterine , S Ahmad Putra Ridwan , Purnomo Agus
Published: July 2021

Usaha Kecil Mikro dan Menengah (UMKM) mempunyai peran yang strategis dalam pembangunan ekonomi nasional, yaitu berperan dalam pertumbuhan ekonomi dan juga berperan dalam pendistribusian hasil-hasil pembangunan. Penelitian ini dilakukan dengan tujuan mengetahui pengaruh pemberdayaan lembaga perkreditan dan sumber pendanaan terhadap manajemen strategi Usaha Mikro Kecil Menengah (UMKM) di Kota Bandar Lampung. Penelitian ini termasuk ke dalam penelitian kuantitatif. Populasi penelitian ini adalah semua pelaku UMKM di Kota Bandar Lampung sebanyak 3.543 UMKM dan jumlah sampel sebanyak 97 UMKM. Analisis dalam penelitian ini menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan hasil uji thitung untuk variabel pemberdayaan lembaga perkreditan sebesar 15,472 (thitung = 15,472 > ttabel =1,974) yang berarti bahwa ada pengaruh pemberdayaan lembaga perkreditan terhadap manajemen strategi Usaha Mikro Kecil Menengah (UMKM) di Kota Bandar Lampung. Hasil uji thitung untuk variabel sumber pendanaan sebesar 5,469 (thitung = 5,469> ttabel =1,974) yang berarti bahwa ada pengaruh sumber pendanaan terhadap manajemen strategi Usaha Mikro Kecil Menengah (UMKM) di Kota Bandar Lampung. Berdasarkan hasil uji F di atas, diperoleh Fhitung = 73,246 > Ftabel = 3,05 dengan signifikansi sebesar 0,014 (< α = 0,05) yang berarti bahwa ada pengaruh pemberdayaan lembaga perkreditan dan sumber pendanaan terhadap manajemen strategi Usaha Mikro Kecil Menengah (UMKM) di Kota Bandar Lampung.
Perkembangan Pasar Modal Syariah di Indonesia
Authors: Haya Nur Anni
Published: July 2021

AbstrakPerkembangan ekonomi tidak dapat dipisahkan dari pasar modal syariah. Selain sebagai sarana pengelolaan dana, masyarakat juga dapat berinvestasi di pasar modal. Investasi dilakukan untuk mengelola modal yang dapat disimpan dan digunakan di masa depan. Sedangkan pasar modal syariah adalah pasar modal yang berdasarkan prinsip syariah. Orang dapat menginvestasikan modalnya tanpa khawatir investasi tersebut mengandung riba, gharar, sifat spekulatif, dan lain-lain. Keberadaan pasar modal syariah ini dapat menarik investor yang dapat berdampak pada peningkatan pertumbuhan ekonomi di Indonesia. Penyelenggaraan pasar modal syariah juga diawasi oleh Dewan Syariah Nasional (DSN). Kendala dari pasar modal syariah ini adalah minimnya masyarakat yang memiliki pengetahuan keuangan dan fiqh muamalah di era modern ini.
tugas hukum tatanegara
Authors: Aswat Muhammad Awal
Published: July 2021

Pada tahun 2045, ketika Indonesia berusia genap 100 tahun, akan terjadi revolusi besar pada Negara ini. Kemajuan dan perkembangan terjadi di semua aspek kehidupan masyarakat. Baik bidang ekonomi, sosial, budaya, politik, pendidikan, dan masih banyak lagi. Dan jika ditinjau dari masa ini, Indonesia memiliki populasi warga Negara dengan usia produktif atau kisaran usia 15-65 tahun terbesar di dunia. Dimana dengan populasi sebanyak itu, dan potensi yang dimiliki warga Negara produktif, maka Indonesia akan mampu menjadi Negara maju pada tahun 2045 nanti. Lalu hal yang harus disiapkan oleh pendidik untuk membekali para generasi muda dalam menghadapi era revolusi industial 4.0 nanti adalah menanamkan nilai-nilai pancasila pada karakter anak bangsa sejak dini. Karena dengan mengamalkan dan mengimplementasikan nilai-nilai pancasila pada kehidupan sehari-hari, pasti generasi muda ini akan menjadi agen perubahan yang mampu bersikap jujur, adil, kritis, revolusioner, dengan berlandaskan iman dan taqwa kepada Tuhan Yang Maha Esa.Kata Kunci: Negara maju, generasi muda, revolusi industrial 4.0, nilai-nilai pancasila
Pasar Modal Syariah dan Konvensional
Authors: Ramadhona Indah
Published: July 2021

Investasi adalah sesuatu yang harus dilakukan hari ini. Investasi sendiri pada dasarnya adalah pengumpulan uang atau apa yang dapat dibandingkan dengan apa yang merupakan simpaun yang akan digunakan untuk masa depan. Saat ini kebanyakan orang berinvestasi dalam saham. Saham adalah surat berharga yang dijual di pasar modal. Pasar modal terbagi menjadi 2 (dua) jenis yaitu pasar modal konvensional dan pasar modal syariah. Dari hasil penelitian ini dapat disimpulkan bahwa: Pasar modal syariah efek yang diperdagangkan haruslah dari perusahaan yang dalam menjalankan kegiatan operasional perusahaannya tidak bertentangan dengan prinsip-prinsip syariah. Sedangkan dalam pasar modal biasa tidak ada aturan yang mengatur tentang kegiatan operasional perusahaan.Landasan hukum pasar modal syariah pada dasarnya adalah Al-Qur’an dan Hadis di pertegas dengan Fatwa Dewan Syariah Nasinonal (DSN) sedangkan pasar modal konvensional adalah Undang-Undang Pasar Modal yaitu Undang-Undang No.8 tahun 1995. Dalam pelaksanaan kegiatannya pasar modal syariah diawasi oleh DSN (Dewan Syariah Nasional), sedangkan pasar modal konvensional tidak. Indeks harga saham konvensional anatara lain IHSG, LQ45, Kompas 100 dll, dan Indeks harga saham syariah ialah JII (Jakarta Islamic Index) dan DES (Daftar Efek Syariah )
Praćenje, izvještavanje i provjera emisija co2 u pomorskom prometu
Authors: Franić Zdenko
Published: July 2021

Kao rezultat emisija ugljikovog dioksida (CO2) i drugih stakleničkih plinova (GHG) koje stvara pomorski promet negativno utječe na globalnu klimu i kvalitetu zraka. Budući da klimatske promjene uzrokuju degradaciju okoliša, što posljedično predstavlja sigurnosni rizik za zdravlje i dobrobit ljudi, moraju se poduzeti odlučne mjere za smanjenje emisija. Smanjenju emisija moraju pridonijeti svi sektori gospodarstva, uključujući međunarodni pomorski promet koji predstavlja oko 13 % ukupne emisije stakleničkih plinova iz EU-a iz prometnog sektora. U ovom radu predstavljeni su EU propisi i postupci za praćenje, izvještavanje i provjeru (MRV) emisija u pomorskom prometu, zajedno sa svim pratećim procesima, poznatim kao ciklus usklađenosti EU ETS (EU Sustav trgovanja emisijama). Smanjenje emisija stakleničkih plinova u brodskoj industriji moglo bi imati cijeli niz povoljnih učinaka: ekonomske (smanjena potrošnja goriva), socijalne (poboljšanje zdravlja ljudi zbog manje izloženosti zagađivačima), administrativne (smanjenje administrativnih prepreka) i ekološke (čišći okoliš).
Pergeseran Konteks Syair Arab pada Masa Jahiliyah Hingga Masa Awal Islam
Authors: Syaifuji Achmad , Irawan Bambang
Published: July 2021

Pada zaman Jahiliyah, kemampuan membuat syair merupakan salah satu parameter intelektualitas seseorang kala itu.  Banyak penyair-penyair handal kala itu, salah satunya disebabkan adanya pergelaran atau festival syair dan puisi Arab yang dilaksanakan di pasar-pasar. Tidak sedikit, sering terjadi konflik yang dipicu karena dendangan syair-syair yang saling menghantam antar suku, merayu para wanita serta perihal negatif lainnya yang salah satunya disebabkan karena orang-orang Jahiliyah tidak mempunyai kitab suci, tidak ada Nabi, dan tidak punya sumber hukum. Saat islam masuk, syair-syair yang bernilai negatif, diganti bahkan dibuang yang disesuaikan dengan nilai-nilai religiositas islam dan sebagai media untuk berdakwah. Hal ini menjadi pertimbangan penulis karena syair merupakan bagian dari kekayaan intelektual dari bahasa Arab itu sendiri, sehingga perlu diketahui karakteristik syair-syair pada masa pra islam hingga masuknya islam. Metode yang dilakukan dalam penelitian ini adalah metode kualitatif dengan cara analisis deskriptif dan kajian pustaka terhadap bahan-bahan dari jurnal ilmiah dan buku-buku yang membahas tentang syair-syair Arab pada masa Jahiliyah hingga awal masuknya islam