bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Laparoscopic and Open Surgery for Women With Early-Stage Epithelial Ovarian Cancer
Authors: Ran Xuting , He Xinlin , Li Zhengyu
Published: April 2022

Objective

This study evaluated the oncologic outcomes of laparoscopy and laparotomy in the management of early-stage ovarian cancer patients.

Methods

We conducted an observational study of women diagnosed with International Federation of Gynecology and Obstetrics (FIGO) 2014 stage I ovarian cancer who underwent surgery at the West China Second University Hospital from 2012 to 2020. Patients who received adjuvant chemotherapy before surgery, those with non-epithelial histopathological types, or those with insufficient data were excluded. Using propensity score matching, data from consecutive laparoscopic patients treated by laparoscopy were matched 1:2 with a cohort of patients undergoing open surgery. The operative and survival outcomes among the matched cohorts were examined using the Kaplan–Meier method.

Results

Among 200 eligible patients, 74 patients undergoing laparoscopy were compared with a cohort of 126 patients undergoing open surgery. Baseline characteristics were similar between groups after matching. Patients who had laparoscopy had a shorter operative time (P = 0.001), a shorter hospital stay (P <0.001), and lower blood loss (P = 0.001) than patients who had open surgery. The median (range) follow-up period was 43.0 (38.8–47.2) and 45.0 (36.0–54.0) months for cases and controls, respectively (P <0.001). There are no significant differences in progression-free survival (P = 0.430, log-rank test) and overall survival (P = 0.067, log-rank test) between the two groups.

Conclusions

There is no difference in prognosis between laparoscopic and open surgery in women with stage I epithelial ovarian cancer. Laparoscopic treatment of early-stage ovarian cancer is safe and feasible for stage I epithelial ovarian cancer patients.
Survival Impacts of Perineural Invasion on Patients Under Different Radical Hysterectomies Due to Early Cervical Cancer
Authors: Wei Wei-wei , Wang Huihui , Zheng Hong , Chen Jiming , Shi Ru-xia
Published: April 2022

Objective

Cervical cancer is a common gynecological malignancy. In addition to the open radical hysterectomy (ORH) and laparoscopic radical hysterectomy (LRH), laparoscopic nerve-sparing radical hysterectomy (LNSRH) could be another treatment option since it could preserve urinary, colorectal, and sexual functions. However, LNSRH might result in early cancer metastasis and recurrence due to inadequate tumor resection. Additionally, whether LNSRH should be considered based on perineural invasion (PNI) status remains controversial. To assess different types of hysterectomy on the outcome of early cervical cancer with PIN.

Methods

A retrospective study was performed in early cervical cancer patients who received ORH, LRH, or LNSRH between January 2012 and December 2019. Age, FIGO cancer stages, histopathological types, tumor size, histological grade, invasion depth, lymph node metastasis, lymphovascular space invasion, and PNI were documented. Disease-free survival (DFS) and overall survival (OS) were recorded.

Results

A total of 174 patients were included, with 33, 69, and 72 patients received LRH, ORH, and LNSRH, respectively. Twenty-one patients (12.1%) had PNI. DFS (P = 0.000) and OS (P = 0.022) periods were shortened in positive PNI patients than in negative PNI patients (P = 0.000 and 0.022, respectively). In patients with positive PNI, lymph node metastasis, but not the surgery type, was an independent risk factor for DFS and OS (P = 0.000).

Conclusion

Early cervical cancer patients with PNI had shorter postoperative DFS and OS periods. In these patients, lymph node metastasis, but not the type of hysterectomy, was independently associated with DFS and OS.
Smilax china L. Polysaccharide Alleviates Oxidative Stress and Protects From Acetaminophen-Induced Hepatotoxicity via Activating the Nrf2-ARE Pathway
Authors: Wang Kaiping , Yang Linlin , Zhou Jing , Pan Xianglin , He Zihao , Liu Junxi , Zhang Yu
Published: April 2022

The alleviation of oxidative stress is considered an effective treatment for acetaminophen (APAP)-induced acute liver injury (AILI). However, it remains unknow whether the potential antioxidant Smilax china L. polysaccharide (SCLP) protects against AILI. In this study, in vitro and in vivo experiments were conducted to verify the hepatoprotective effect of SCLP against AILI and explore the potential mechanism. We found that SCLP relieved liver histopathological changes; reversed the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA) and reactive oxygen species (ROS); reversed the change in liver myeloperoxidase (MPO) activity; and enhanced liver antioxidant (GSH, GSH-Px, and t-SOD) levels in APAP-treated mice, thereby significantly reducing APAP-induced liver toxicity. SCLP rescued the cell viability and alleviated oxidative stress in H2O2-treated mouse AML12 (Alpha mouse liver 12) hepatocytes. The results of the mechanistic studies showed that SCLP upregulated nuclear factor E2 related factor (Nrf2) expression, promoted Nrf2 nuclear translocation, and enhanced the ability of Nrf2 to bind antioxidant response elements (AREs). Furthermore, SCLP activated Nrf2-ARE pathway, thus upregulating the expression of oxidative stress-related proteins heme oxygenase 1(HO-1), NAD(P)H quinone dehydrogenase 1(NQO-1) and glutamic acid cysteine ligase catalytic subunit (GCLC). In conclusion, this study confirmed the close correlation between liver protection by SCLP upon exposure to APAP and activated of the Nrf2-ARE pathway. These findings suggest that SCLP is an attractive therapeutic candidate drug for the treatment of AILI.
Generation of High Peak Power Pulses With Controllable Repetition Rate in Doubly Q-Switched Laser With AOM/SnSe2
Authors: Xia Jingxuan , Dong Xu , Yuan Hanming
Published: April 2022

By simultaneously employing self-made SnSe2 saturable absorber (SA) and an acous-to-optic modulator (AOM), a dual-loss-modulated Q-switched Nd:YVO4 laser with short pulse width, high peak power and adjustable pulse repetition rate is presented. The maximum pulse peak power of 37.57 KW with the minimum pulse duration of 5.52 ns were obtained under the pump power of 8 W and the pulse repetition rate of 5 kHz. The experimental results demonstrate that the dual-loss modulation technology with AOM and SnSe2 SA is a simple and efficient method to generate short pulses with high peak power and adjustable low repetition rates.
A Review on Metamaterial Absorbers: Microwave to Optical
Authors: Abdulkarim Yadgar I. , Mohanty Ayesha , Acharya Om Prakash , Appasani Bhargav , Khan Mohammad S. , Mohapatra S. K. , Muhammadsharif Fahmi F. , Dong Jian
Published: April 2022

Metamaterials (MM) are artificially designed materials that possess unique properties due to their geometrical design. They also display some peculiar properties, such as negative refractive index, Snell’s law reversal, Doppler effect reverse, and left-handed behavior. MMs are used in a myriad of applications, including invisibility cloaking, perfect lensing, perfect absorption, and sensing. In this review article, the property of electromagnetic absorption by structures known as metamaterial absorbers (MMAs) is discussed. An MMA is a composite made up of many layers of metallic patterns separated by dielectric. This novel device helps in achieving near-unity absorption by various mechanisms, which are investigated in this article. The MMAs are classified based on their absorption characteristics, such as polarization tunability, broadband operation, and multiband absorption, in different frequency regimes.
Recent Developments in Mouse Trauma Research Models: A Mini-Review
Authors: Gihring Adrian , Gärtner Fabian , Schirmer Melanie , Wabitsch Martin , Knippschild Uwe
Published: April 2022

The urgency to investigate trauma in a controlled and reproducible environment rises since multiple trauma still account for the most deaths for people under the age of 45. The most common multiple trauma include head as well as blunt thorax trauma along with fractures. However, these trauma remain difficult to treat, partially because the molecular mechanisms that trigger the immediate immune response are not fully elucidated. To illuminate these mechanisms, investigators have used animal models, primarily mice as research subjects. This mini review aims to 1) emphasize the importance of the development of clinically relevant murine trauma research, 2) highlight and discuss the existing conflict between simulating clinically relevant situations and elucidating molecular mechanisms, 3) describe the advantages and disadvantages of established mouse trauma models developed to simulate clinically relevant situations, 4) summarize and list established mouse models in the field of trauma research developed to simulate clinically relevant situations.
Effects of Crowding and Water Flow on Golden Shiners Notemigonus crysoleucas, Held in a Flow Tank
Authors: Kaimal Sindhu , Haukenes A. H. , Renukdas Nilima N. , Kelly Anita M.
Published: April 2022

Split-pond systems (SPS) such as those used for catfish are being considered for raising baitfish. When using these systems for baitfish such as golden shiners Notemigonus crysoleucas, an important factor to be considered is how well the species can tolerate crowding, as the design mandates fish be confined to a smaller portion of the pond. Another aspect of the SPS design is the water flow between the two units for at least 10–14 h each day. SPS can be successfully implemented for other species if factors such as crowding, and water flow do not affect growth. Two laboratory studies were conducted each using 12, 40-L tank flow-through system to observe the growth and physiological performance of golden shiners held for 28 days at three crowding densities: 600; 1,200, and 2,400 fish/m3, keeping water flow at 1 cm/s (Experiment 1) and using three flow rates: 1, 2, and 4 cm/s at similar densities (600 fish/m3) (Experiment 2). At the end of the experiments, fish were subject to acute 1-min confinement stress and whole-body cortisol was measured at 30 min intervals for up to 2 h to monitor the secretion pattern and recovery. Results from experiments showed no difference in the final weight, length, feed conversion, and survival among treatment groups; survival rates were lower in the flow study because of columnaris Flavobacterium covae infections. Baseline cortisol was also not different among the treatments. Cortisol increased 30 min after the acute stress and returned to near baseline in 2 h in the crowding study suggesting acclimation to the chronic stressor. However, in the flow study, cortisol remained elevated even after 2 h, and hence a compromised pathophysiological response. Crowding and water flow do not impair feed intake, growth, or survival in golden shiners, and in these aspects may be a suitable species for SPS.
Muscle Shear Elastic Modulus Provides an Indication of the Protection Conferred by the Repeated Bout Effect
Authors: Chalchat Emeric , Siracusa Julien , Bourrilhon Cyprien , Charlot Keyne , Martin Vincent , Garcia-Vicencio Sebastian
Published: April 2022

Background: The neuromuscular system is able to quickly adapt to exercise-induced muscle damage (EIMD), such that it is less affected by subsequent damaging exercise, a phenomenon known as the repeated bout effect (RBE). The objective was to determine whether the mechanical properties of the quadriceps, as evaluated by shear wave elastography (SWE), were less affected when a second bout of eccentric-biased exercise was performed 2 weeks later. It was hypothesized that the first bout would confer protection against extensive muscle damage through an adaptation of the muscle stiffness before the second bout (i.e., higher muscle stiffness).

Methods: Sixteen males performed two identical bouts of downhill walking separated by 2 weeks (45 min at 4.5 km.h−1; gradient: 25%; load: 30% of the body mass). Rectus femoris (RF) and vastus lateralis (VL) resting shear elastic modulus (µ) and EIMD symptoms were measured before and up to 7 days following the exercise bouts. Changes in neuromuscular function was evaluated by maximal voluntary contraction torque, voluntary activation level, evoked mechanical response to single and double (10 and 100 Hz doublets) electrical stimulation. An index of protection (IP) was calculated for EIMD symptoms to assess magnitude the RBE.

Results: EIMD symptoms were less affected after the second than the first exercise bout. RF and VL-µ increased (p < 0.001) only after the first exercise. RF µ was elevated up to 2 weeks after the end of the first exercise (p < 0.001) whereas VL µ was only increased up to 24 h. The increase in µ observed 2 weeks after the end of the first exercise was correlated with the IP; i.e., attenuation of alterations in muscle µ, 10 Hz-doublet amplitude and rate of torque development after the second exercise bout (p < 0.05).

Conclusion: We showed that muscle µ assessed by SWE was sensitive to the RBE, with a differential effect between VL and RF. The persistent increase in µ was associated with the attenuation of neuromuscular impairments observed after the second bout, suggesting that the increased muscle stiffness could be a “protective” adaptation making muscles more resistant to the mechanical strain associated to eccentric contractions.
Pigment Dispersing Factor Is a Circadian Clock Output and Regulates Photoperiodic Response in the Linden Bug, Pyrrhocoris apterus
Authors: Kotwica-Rolinska Joanna , Damulewicz Milena , Chodakova Lenka , Kristofova Lucie , Dolezel David
Published: April 2022

Daily and annually cycling conditions manifested on the Earth have forced organisms to develop time-measuring devices. Circadian clocks are responsible for adjusting physiology to the daily cycles in the environment, while the anticipation of seasonal changes is governed by the photoperiodic clock. Circadian clocks are cell-autonomous and depend on the transcriptional/translational feedback loops of the conserved clock genes. The synchronization among clock centers in the brain is achieved by the modulatory function of the clock-dependent neuropeptides. In insects, the most prominent clock neuropeptide is Pigment Dispersing Factor (PDF). Photoperiodic clock measures and computes the day and/or night length and adjusts physiology accordingly to the upcoming season. The exact mechanism of the photoperiodic clock and its direct signaling molecules are unknown but, in many insects, circadian clock genes are involved in the seasonal responses. While in Drosophila, PDF signaling participates both in the circadian clock output and in diapause regulation, the weak photoperiodic response curve of D. melanogaster is a major limitation in revealing the full role of PDF in the photoperiodic clock. Here we provide the first description of PDF in the linden bug, Pyrrhocoris apterus, an organism with a robust photoperiodic response. We characterize in detail the circadian and photoperiodic phenotype of several CRISPR/Cas9-generated pdf mutants, including three null mutants and two mutants with modified PDF. Our results show that PDF acts downstream of CRY and plays a key role as a circadian clock output. Surprisingly, in contrast to the diurnal activity of wild-type bugs, pdf null mutants show predominantly nocturnal activity, which is caused by the clock-independent direct response to the light/dark switch. Moreover, we show that together with CRY, PDF is involved in the photoperiod-dependent diapause induction, however, its lack does not disrupt the photoperiodic response completely, suggesting the presence of additional clock-regulated factors. Taken together our data provide new insight into the role of PDF in the insect’s circadian and photoperiodic systems.
Glia-Neurons Cross-Talk Regulated Through Autophagy
Authors: Damulewicz Milena , Szypulski Kornel , Pyza Elzbieta
Published: April 2022

Autophagy is a self-degradative process which plays a role in removing misfolded or aggregated proteins, clearing damaged organelles, but also in changes of cell membrane size and shape. The aim of this phenomenon is to deliver cytoplasmic cargo to the lysosome through the intermediary of a double membrane-bound vesicle (autophagosome), that fuses with a lysosome to form autolysosome, where cargo is degraded by proteases. Products of degradation are transported back to the cytoplasm, where they can be re-used. In the present study we showed that autophagy is important for proper functioning of the glia and that it is involved in the regulation of circadian structural changes in processes of the pacemaker neurons. This effect is mainly observed in astrocyte-like glia, which play a role of peripheral circadian oscillators in the Drosophila brain.
Eutrema EsMYB90 Gene Improves Growth and Antioxidant Capacity of Transgenic Wheat Under Salinity Stress
Authors: Li Chuanshun , Zhao Yaoyao , Qi Yuting , Duan Chonghao , Zhang Hengyang , Zhang Quan
Published: April 2022

The ectopic expression of the EsMYB90 transcription factor gene from halophytic Eutrema salsugineum has been reported to enhance the level of anthocyanin and other flavonoid metabolites in transgenic tobacco. In this study, the wheat JW1 overexpressing EsMYB90 showed longer roots and higher fresh weight than that in wild type (WT) under salt stress. In addition, the transgenic wheat plants displayed significantly higher peroxidase (POD) and glutathione S-transferase (GST) activity, as well as markedly lower malondialdehyde (MDA) content than that of the WT during salt stress conditions. The analysis of histochemical staining and H2O2 level indicated that the accumulation of reactive oxygen species (ROS) was significantly lower in the roots of transgenic wheat plants compared to the WT under salt stress. Transcriptome analysis revealed that the EsMYB90 gene affected the expression of considerable amounts of stress-related genes that were involved in phenylpropanoid biosynthesis and antioxidant activity in transgenic plants subjected to NaCl treatment. Importantly, the significantly upregulated expression genes in transgenic wheat under salt stress were mainly associated with the antioxidative enzymes POD and GST encoding genes compared with the WT. Furthermore, EsMYB90 is suggested to bind with the MYB-binding elements of pTaANS2 and pTaDFR1 by dual luciferase assay, to activate the transcription of TaANS2 and TaDFR1 genes that are encoding key enzymes of anthocyanin biosynthesis in transgenic wheat plants. All the results indicated that, under salt stress, the EsMYB90 gene plays a crucial role in preventing wheat seedlings from oxidative stress damage via enhancing the accumulation of non-enzymatic flavonoids and activities of antioxidative enzymes, which suggested that EsMYB90 is an ideal candidate gene for the genetic engineering of crops.
CBL-Interacting Protein Kinase OsCIPK18 Regulates the Response of Ammonium Toxicity in Rice Roots
Authors: Sun Tong , Wang Ting , Qiang Yalin , Zhao Gangqing , Yang Jian , Zhong Hua , Peng Xiaojue , Yang Jing , Li Yangsheng
Published: April 2022

Ammonium (NH4+) is one of the major nitrogen sources for plants. However, excessive ammonium can cause serious harm to the growth and development of plants, i.e., ammonium toxicity. The primary regulatory mechanisms behind ammonium toxicity are still poorly characterized. In this study, we showed that OsCIPK18, a CBL-interacting protein kinase, plays an important role in response to ammonium toxicity by comparative analysis of the physiological and whole transcriptome of the T-DNA insertion mutant (cipk18) and the wild-type (WT). Root biomass and length of cipk18 are less inhibited by excess NH4+ compared with WT, indicating increased resistance to ammonium toxicity. Transcriptome analysis reveals that OsCIPK18 affects the NH4+ uptake by regulating the expression of OsAMT1;2 and other NH4+ transporters, but does not affect ammonium assimilation. Differentially expressed genes induced by excess NH4+ in WT and cipk18 were associated with functions, such as ion transport, metabolism, cell wall formation, and phytohormones signaling, suggesting a fundamental role for OsCIPK18 in ammonium toxicity. We further identified a transcriptional regulatory network downstream of OsCIPK18 under NH4+ stress that is centered on several core transcription factors. Moreover, OsCIPK18 might function as a transmitter in the auxin and abscisic acid (ABA) signaling pathways affected by excess ammonium. These data allowed us to define an OsCIPK18-regulated/dependent transcriptomic network for the response of ammonium toxicity and provide new insights into the mechanisms underlying ammonium toxicity.
Bio-Insecticidal Nanoemulsions of Essential Oil and Lipid-Soluble Fractions of Pogostemon cablin
Authors: Manjesh Keerthiraj , Kundu Aditi , Dutta Anirban , Saha Supradip , Neelakanthaiah Bhagyasree Sira
Published: April 2022

The present study aimed to develop nanoemulsions (NEs) of essential oil (EO) and lipid-soluble extract (HE) of Pogostemon cablin leaves using biosurfactant, saponin. Hydro-distilled EO and fat-soluble HE were analyzed using GC-MS, which revealed 38.7 ± 2.7% and 37.5 ± 2.1% patchoulol, respectively. EO and HE were formulated with saponin to prepare corresponding coarse emulsions (CEs); furthermore, high-speed homogenization for 2 min was followed by ultrasonication for 3 min with constant frequency of 50 kHz. of the CEs resulted in respective NEs. NEs were characterized for the physico-chemical properties such as emulsion intrinsic stability, particle size distribution, polydispersity index (PDI), and transmission electron microscopy (TEM) for morphology and accurate nanodroplet diameters. CEs and NEs were investigated for insecticidal efficacy against adults of Tetranychus urticae and larvae of Spodoptera litura. Stable NEs of EO and HE at 500 μg mL−1 concentration exhibited corresponding average particle size of 51.7 and 89.9 nm, while TEM image revealed spherical-shaped droplets with the average droplet diameters of 15.3 and 29.4 nm, respectively. NEs of EO and HE displayed highest efficacy in contact toxicity (LC50 43.2 and 58.4 μg mL−1) after 48 h and fumigant toxicity (LC50 9.3 and 13.6 μg mL−1) after 24 h against T. urticae. In addition, NEs of EO showed considerable antifeedant and feeding deterrent action (AI 99.21 ± 0.74 and FI 99.73 ± 1.24) against S. litura larvae.
Psychosocial Effects of COVID-19 in the Ecuadorian and Spanish Populations: A Cross-Cultural Study
Authors: Chocho-Orellana Ángela Ximena , Samper-García Paula , Malonda-Vidal Elisabeth , Llorca-Mestre Anna , Zarco-Alpuente Alfredo , Mestre-Escrivá Vicenta
Published: April 2022

The world's population is currently overcoming one of the worst pandemics, and the psychological and social effects of this are becoming more apparent. We will present an analysis of the psychosocial effects of COVID-19: first, a cross-sectional study in an Ecuadorian sample (n = 301) and second, a comparative study between two samples from the Ecuadorian and Spanish populations (n = 83 each one). Participants completed an online survey to (1) describe how they felt (depression, anxiety, and stress) before and after confinement; (2) analyze which emotional and behavioral variables predict depressive symptoms, anxiety, and stress perceived after the confinement; (3) carry out a comparative study in a sample of Ecuadorian and Spanish surveys. Results indicate, first, that Ecuadorians experience significantly more depressive symptoms, anxiety, and stress after confinement. Second, variables which predict depressive symptoms and anxiety are greater public prosocial tendency, less stress as a challenge, and greater stress as a threat, as well as an empathetic tendency that implies greater emotional regulation. Experienced stress after confinement was predicted by a greater public prosocial tendency, as well as an empathetic tendency. Finally, scores for depression, anxiety, and stress are higher after confinement in both countries. However, results reveal the similarity of the psychosocial effects that are being experienced, regardless of the country, and the differences in the variables that can help explain these effects. This can contribute to the constitution of intervention plans which aim to soften and alleviate the effects produced by a situation such as that experienced with COVID-19.
High-Performance Work Practices and Interpersonal Relationships: Laissez-Faire Leadership as a Risk Factor
Authors: Salin Denise , Baillien Elfi , Notelaers Guy
Published: April 2022

Although high-performance work practices (HPWPs) have been shown to increase organizational performance and improve employee attitudes, it still remains unclear how they impact interpersonal relations in the workplace. While some argue that HPWPs lead to better interpersonal relations, others fear that HPWPs may increase competition and uncivil and abusive behaviors. In response to this, our aim is to examine whether and when HPWPs are associated with increased levels of competition and thereby more incivility. Given recent interest in how HR practices and leadership may interact to produce certain outcomes, we study laissez-faire leadership as a possible moderator. A survey was conducted in Belgium (n = 374), and a mediated moderation analysis using SEM performed using Mplus. The results suggest that in the absence of laissez-faire leadership, HPWPs are associated with less incivility, thus suggesting better interpersonal relations. However, the results also show that HPWPs may lead to increased competition and thereby somewhat more incivility, under conditions of laissez-faire leadership. The results thus point to the importance of studying interactions between HR practices and leadership in trying to understand employee outcomes. In terms of practical implications, the results suggest that investing in HPWPs may reduce incivility and thereby improve relationship wellbeing. However, HPWPs need to be combined with active leadership to avoid undesirable negative consequences.
“I Think Friendship Over This Lockdown Like Saved My Life”—Student Experiences of Maintaining Friendships During COVID-19 Lockdown: An Interpretative Phenomenological Study
Authors: Maloy Amy , Main Annischa , Murphy Claire , Coleman Lauren , Dodd Robson , Lynch Jessica , Larkin Donna , Flowers Paul
Published: April 2022

COVID-19 lockdown presented a novel opportunity to study the experiences of people attempting to maintain friendships in the context of worldwide, government-enforced physical distancing and lockdown. Here we report on an experiential, idiographic qualitative project with a purposive sample of Scottish students. Data was collected via one-to-one on-line interviews with nine student participants (N = 9). Data was transcribed and analyzed using Interpretative Phenomenological Analysis (IPA). Analysis highlighted three group-level experiential themes (GETs) and associated subthemes. Participants’ shared experiences of maintaining friendships were reflected in a dynamic process by which (1) ‘changes to communication’ were associated with experiences of (2) ‘effort and balance’ across friendships. Participants reported becoming particularly aware of the psychological processes involved in maintaining friendships, in turn, this was associated with (3) ‘reflection and growth.’ These experiential findings resonate well with several longstanding classic theories; however, they also speak to the particularities of the context in which the study was conducted. They suggest the need for a pandemic psychology that moves beyond the typical focus on the direct impacts of infectious disease to address the wider psychosocial impacts with equal vigor.
Semantic Working Memory Predicts Sentence Comprehension Performance: A Case Series Approach
Authors: Horne Autumn , Zahn Rachel , Najera Oscar I. , Martin Randi C.
Published: April 2022

Sentence comprehension involves maintaining and continuously integrating linguistic information and, thus, makes demands on working memory (WM). Past research has demonstrated that semantic WM, but not phonological WM, is critical for integrating word meanings across some distance and resolving semantic interference in sentence comprehension. Here, we examined the relation between phonological and semantic WM and the comprehension of center-embedded relative clause sentences, often argued to make heavy demands on WM. Additionally, we examined the relation between phonological and semantic WM and the comprehension of transitive and dative active and passive sentences, which may also draw on WM resources depending on the number of propositions that must be maintained and the difficulty of processing passive clauses. In a large sample of individuals with aphasia (N = 56), we assessed whether comprehension performance on more complex vs. simpler active-passive or embedded relative clause sentences would be predicted by semantic but not phonological WM when controlling for single word comprehension. For performance on the active-passive comprehension task, we found that semantic WM, but not phonological WM, predicted comprehension of dative sentences when controlling for comprehension of transitive sentences. We also found that phonological WM, but not semantic WM, predicted mean comprehension for reversible active-passive sentences when controlling for trials with lexical distractors. On the relative clause comprehension task, consistent with prior results, we found that semantic WM, but not phonological WM, predicted comprehension of object relative clause sentences and relative clause sentences with a passive construction. However, both phonological WM and semantic WM predicted mean comprehension across all relative clause types for reversible trials when controlling for trials with lexical distractors. While we found evidence of semantic WM’s role in comprehension, we also observed unpredicted relations between phonological WM and comprehension in some conditions. Post-hoc analyses provided preliminary evidence that phonological WM maintains a backup phonological representation of the sentence that may be accessed when sentence comprehension processing is less efficient. Future work should investigate possible roles that phonological WM may play across sentence types.
Influence of Organizational Learning and Dynamic Capability on Organizational Performance of Human Resource Service Enterprises: Moderation Effect of Technology Environment and Market Environment
Authors: Chen Shuilin , Zheng Jianguo
Published: April 2022

This study aims to explore the influence of organizational learning and dynamic capability on organizational performance of human resource service enterprises with the moderating role of technology environment and market environment. Data were gathered from 360 human resource service enterprises, and applied the hierarchical linear regression method and structural equation model to test the hypotheses. We found that organizational learning has a significantly positive impact on resource integration capability, as well as has a significantly positive impact on resource reconfiguration capability of human resource service enterprises. Resource integration capability and resource reconfiguration capability have a significantly positive impact on organizational performance. Moreover, results indicated that the resource integration capability and resource reconfiguration capability partially mediate in the relationship between organizational learning and organizational performance. Furthermore, technology environment and market environment have positive moderation effect between resource integration capability and organizational performance of human resource service enterprises, as well as have positive moderation effect between resource reconfiguration capability and organizational performance of human resource service enterprises. The current study contributes to a better understand the impact mechanism of organizational learning on organizational performance from the perspective of organizational learning theory and dynamic capability theory. In addition, this study provides implications for human resource service enterprises and managers to improve organizational performance.
Research Trends in Individuals at High Risk for Psychosis: A Bibliometric Analysis
Authors: Lee Tae Young , Lee Soo Sang , Gong Byoung-gyu , Kwon Jun Soo
Published: April 2022

The study of clinical high risk for psychosis (CHR-P) has progressed rapidly over the last decades and has developed into a significant branch of schizophrenia research. Organizing the information about this rapidly growing subject through bibliometric analysis enables us to gain a better understanding of current research trends and future directions to be pursued. Electronic searches from January 1991 to December 2020 yielded 5,601 studies, and included 1,637 original articles. After processing the data, we were able to determine that this field has grown significantly in a short period of time. It has been confirmed that researchers, institutions, and countries are collaborating closely to conduct research; moreover, these networks are becoming increasingly complex over time. Additionally, there was a shift over time in the focus of the research subject from the prodrome, recognition, prevention, diagnosis to cognition, neuroimaging, neurotransmitters, cannabis, and stigma. We should aim for collaborative studies in which various countries participate, thus covering a wider range of races and cultures than would be covered by only a few countries.
Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice
Authors: Yi Sha-sha , Zou Jun-jie , Meng Long , Chen Hou-minji , Hong Zhong-qiu , Liu Xiu-fang , Farooq Umar , Chen Mo-xian , Lin Zheng-rong , Zhou Wei , Ao Li-juan , Hu Xi-quan , Niu Li-li
Published: April 2022

Increasing evidence indicates that inflammatory responses may influence brain neurochemical pathways, inducing depressive-like behaviors. Ultrasound stimulation (US) is a promising non-invasive treatment for neuropsychiatric diseases. We investigated whether US can suppress inflammation and improve depressive-like behaviors. Mice were intraperitoneally injected with lipopolysaccharide to induce depressive-like behaviors. Ultrasound wave was delivered into the prefrontal cortex (PFC) for 30 min. Depressive- and anxiety-like behaviors were evaluated through the forced swimming test (FST), tail suspension test (TST), and elevated plus maze (EPM). Biochemical analyses were performed to assess the expression of inflammatory cytokines in the PFC and serum. The results indicated that US of the PFC significantly improved depressive-like behaviors in the TST (p < 0.05) and FST (p < 0.05). Anxiety-like behaviors also improved in the EPM (p < 0.05). Furthermore, the lipopolysaccharide-mediated upregulation of IL-6, IL-1β, and TNF-α in the PFC was significantly reduced (p < 0.05) by US. In addition, no tissue damage was observed. Overall, US of PFC can effectively improve lipopolysaccharide-induced depressive-like behaviors, possibly through the downregulation of inflammatory cytokines in the PFC. US may be a safe and promising tool for improvement of depression.
Machine Learning-Based Prediction Models for Depression Symptoms Among Chinese Healthcare Workers During the Early COVID-19 Outbreak in 2020: A Cross-Sectional Study
Authors: Zhou Zhaohe , Luo Dan , Yang Bing Xiang , Liu Zhongchun
Published: April 2022

Background

The 2019 novel coronavirus (COVID-19)-related depression symptoms of healthcare workers have received worldwide recognition. Although many studies identified risk exposures associated with depression symptoms among healthcare workers, few have focused on a predictive model using machine learning methods. As a society, governments, and organizations are concerned about the need for immediate interventions and alert systems for healthcare workers who are mentally at-risk. This study aims to develop and validate machine learning-based models for predicting depression symptoms using survey data collected during the COVID-19 outbreak in China.

Method

Surveys were conducted of 2,574 healthcare workers in hospitals designated to care for COVID-19 patients between 20 January and 11 February 2020. The patient health questionnaire (PHQ)-9 was used to measure the depression symptoms and quantify the severity, a score of ≥5 on the PHQ-9 represented depression symptoms positive, respectively. Four machine learning approaches were trained (75% of data) and tested (25% of data). Cross-validation with 100 repetitions was applied to the training dataset for hyperparameter tuning. Finally, all models were compared to evaluate their predictive performances and screening utility: decision tree, logistics regression with least absolute shrinkage and selection operator (LASSO), random forest, and gradient-boosting tree.

Results

Important risk predictors identified and ranked by the machine learning models were highly consistent: self-perceived health status factors always occupied the top five most important predictors, followed by worried about infection, working on the frontline, a very high level of uncertainty, having received any form of psychological support material and having COVID-19-like symptoms. The area under the curve [95% CI] of machine learning models were as follows: LASSO model, 0.824 [0.792–0.856]; random forest, 0.828 [0.797–0.859]; gradient-boosting tree, 0.829 [0.798–0.861]; and decision tree, 0.785 [0.752–0.819]. The calibration plot indicated that the LASSO model, random forest, and gradient-boosting tree fit the data well. Decision curve analysis showed that all models obtained net benefits for predicting depression symptoms.

Conclusions

This study shows that machine learning prediction models are suitable for making predictions about mentally at-risk healthcare workers predictions in a public health emergency setting. The application of multidimensional machine learning models could support hospitals' and healthcare workers' decision-making on possible psychological interventions and proper mental health management.
A Bibliometric Analysis of Personal Protective Equipment and COVID-19 Researches
Authors: Zhang Yu , Hu Man , Wang Junwu , Wang Pingchuan , Shi Pengzhi , Zhao Wenjie , Liu Xin , Peng Qing , Meng Bo , Feng Xinmin , Zhang Liang
Published: April 2022

COVID-19, which occurred at the end of December 2019, has evolved into a global public health threat and affects every aspect of human life. COVID-19's high infectivity and mortality prompted governments and the scientific community to respond quickly to the pandemic outbreak. The application of personal protective equipment (PPE) is of great significance in overcoming the epidemic situation. Since the discovery of severe acute respiratory coronavirus 2 (SARS-CoV-2), bibliometric analysis has been widely used in many aspects of the COVID-19 epidemic. Although there are many reported studies about PPE and COVID-19, there is no study on the bibliometric analysis of these studies. The citation can be used as an indicator of the scientific influence of an article in its field. The aim of this study was to track the research trends and latest hotspots of COVID-19 in PPE by means of bibliometrics and visualization maps.
Crowdsourced Data for Physical Activity-Built Environment Research: Applying Strava Data in Chengdu, China
Authors: Yang Linchuan , Yu Bingjie , Liang Pengpeng , Tang Xianglong , Li Ji
Published: April 2022

The lack of physical activity has become a rigorous challenge for many countries, and the relationship between physical activity and the built environment has become a hot research topic in recent decades. This study uses the Strava Heatmap (novel crowdsourced data) to extract the distribution of cycling and running tracks in central Chengdu in December 2021 (during the COVID-19 pandemic) and develops spatial regression models for numerous 500 × 500 m grids (N = 2,788) to assess the impacts of the built environment on the cycling and running intensity indices. The findings are summarized as follows. First, land-use mix has insignificant effects on the physical activity of residents, which largely contrasts with the evidence gathered from previous studies. Second, road density, water area, green space area, number of stadiums, and number of enterprises significantly facilitate cycling and running. Third, river line length and the light index have positive associations with running but not with cycling. Fourth, housing price is positively correlated with cycling and running. Fifth, schools seem to discourage these two types of physical activities during the COVID-19 pandemic. This study provides practical implications (e.g., green space planning and public space management) for urban planners, practitioners, and policymakers.
Testing the Stochastic Convergence of Ecological Indicators in BRICS in the Perspective of Public Health
Authors: Wu Jinshun
Published: April 2022

This paper assesses the stochastic convergence of relative per capita ecological footprints within BRICS countries over the period 1961–2017 in the field of Public Health. Our initiatives have targeted ecological Indicator and health behaviors. Using the local Whittle estimator and some of its variants we assess whether relative per capita ecological footprints are long memory processes which, although highly persistent, may revert to their mean/trend in the long run thereby indicating evidence of stochastic convergence, or divergent processes in nutshell. Furthermore, we test whether (possibly) slow convergence or the complete lack of it may be the result of structural changes to the deterministics of each of the relative per capita footprint series by means of the tests of Berkes et al. (1) and Mayoral (2). For the ease of comparison, this paper assesses the stochastic convergence of relative per capita ecological capacities for BRICS as well. Our results show relatively strong evidences against stochastic convergence of ecological footprints. Furthermore, with regard to China and Russia, our results also decisively indicate that a slow or lack of convergence is the results of a structural break in the relative per capita ecological footprint series. However, our empirical researches support stochastic convergence of relative per capita ecological capacities for BRICS. In addition, we can conclude whether the per capita ecological footprints converge or not is dependent on the level of economic development, and the stochastic convergence occurs in those rich countries more probably, indicating that public health is becoming a more serious concern in developing countries.
Trust and Cooperation
Authors: Kuipers Benjamin
Published: April 2022

We AI researchers are concerned about the potential impact of artificially intelligent systems on humanity. In the first half of this essay, I argue that ethics is an evolved body of cultural knowledge that (among other things) encourages individual behavior that promotes the welfare of the society (which in turn promotes the welfare of its individual members). The causal paths involved suggest thattrustandcooperationplay key roles in this process. In the second half of the essay, I consider whether the key role of trust exposes our society to existential threats. This possibility arises because decision-making agents (humans, AIs, and others) necessarily rely on simplified models to cope with the unbounded complexity of our physical and social world. By selecting actions to maximize a utility measure, a well-formulated game theory model can be a powerful and valuable tool. However, a poorly-formulated game theory model may be uniquely harmful, in cases where the action it recommends deliberately exploits the vulnerability and violates the trust of cooperative partners. Widespread use of such models can erode the overall levels of trust in the society. Cooperation is reduced, resources are constrained, and there is less ability to meet challenges or take advantage of opportunities. Loss of trust will affect humanity’s ability to respond to existential threats such as climate change.
Personalizing Virtual Reality for the Research and Treatment of Fear-Related Disorders: A Mini Review
Authors: Bergsnev Kamilla , Sánchez Laws Ana Luisa
Published: April 2022

This mini review presents the current state of the art in studies on the personalization of virtual reality for basic research and treatment of fear-related disorders. Of particular interest to the review are the choice of self-report measures and manipulations of contextual factors that researchers are using in their virtual reality procedures. As this mini review will show, work is starting to emerge on the area of the interaction between context and individual differences, yet this topic remains a current gap in the literature on fear learning mechanisms and therapies for fear-related disorders. Studies in this review conclude that virtual reality environments offer many advantages, as they can be adjusted to model different contexts with great precision and control of the experimental context. Virtual reality is also seen by researchers as an opportunity to decrease the translational gap that exists between the research laboratories and the practical use for therapy treatments in clinics. However, the heterogeneity of methodological approaches that have created replicability as well as comparability issues in the field of fear learning is also a concern in studies using virtual reality. Thus, another, albeit secondary, aim of this mini review will be to point out some of the methodological challenges that should be addressed in future research aimed at the personalization of virtual reality for the research and treatment of fear-related disorders. Factors that will be addressed are 1) the use of self-report measures, and 2) interactivity aspects of contextual factor design in the virtual reality environment.