bluuebunny/crossref_metadata_2025 huggingface dataset:
Dating App Use and Wellbeing: An Application-Based Pilot Study Employing Ecological Momentary Assessment and Objective Measures of Use
Authors: Bonilla-Zorita Gabriel , Griffiths Mark D. , Kuss Daria J.
Published: April 2023

Smartphones are part of individuals’ daily lifestyles, as are smartphone applications such as dating apps. Previous evidence suggests that high engagement in dating applications can be detrimental to some users’ wellbeing. However, much of the published research has relied on cross-sectional studies and self-report measures. Therefore, the present study aims to overcome the limitations of subjective measures in cross-sectional designs by investigating for the first time the relationship between dating app users’ wellbeing (self-esteem, craving and mood) and objective measures of their use during a one-week period. To do this, the present study employed a newly developed application, DiaryMood and utilized ecological momentary assessment (EMA), as it measured subjects’ mood, self-esteem and craving three times per day and the time spent using the dating apps per day during one week. A convenience sample of 22 online dating app users participated in the present study. Findings from a three-level multilevel analysis indicated that increased time spent on dating apps predicted craving among dating app users and that notifications led to an improved mood and higher self-esteem. The results are discussed in relation to previous online dating studies. In sum, the present study sets a precedent for the use of EMA within the scope of online dating research, which may promote further studies adopting this methodology.
Comparing Communication Methods to Increase Radon Knowledge and Home Testing: A Randomized Controlled Trial in a High-Radon City
Authors: Kim Soojung , Scheffer-Wentz Hannah , Klug Marilyn G. , Schwartz Gary G.
Published: April 2023

Introduction: Exposure to residential radon is a preventable cause of cancer. Prevention requires testing, but the percentage of homes that have been tested is small. One reason for the low testing rates may be that printed brochures fail to motivate people to obtain and return a radon test. Methods: We developed a radon app for smartphones that contained the same information as printed brochures. We conducted a randomized, controlled trial that compared the app to brochures in a population comprised largely of homeowners. Cognitive endpoints included radon knowledge, attitudes toward testing, perceived severity and susceptibility to radon, and response and self-efficacy. Behavioral endpoints were participants’ requests for a free radon test and the return of the test to the lab. Participants (N = 116) were residents of Grand Forks, North Dakota, a city with one of the nation’s highest radon levels. Data were analyzed by general linear models and logistic regression. Results: Participants in both conditions showed significant increases in radon knowledge (p < 0.001), perceived susceptibility (p < 0.001), and self-efficacy (p = 0.004). There was a significant interaction, with app users showing greater increases. After controlling for income, app users were three times more likely to request a free radon test. However, contrary to expectation, app users were 70% less likely to return it to the lab (p < 0.01). Conclusions: Our findings confirm the superiority of smartphones in stimulating radon test requests. We speculate that the advantage of brochures in promoting test returns may be due to their ability to serve as physical reminders.
Therapeutic Lymphangiogenesis Is a Promising Strategy for Secondary Lymphedema
Authors: Shimizu Yuuki , Che Yiyang , Murohara Toyoaki
Published: April 2023

Secondary lymphedema is caused by lymphatic insufficiency (lymphatic drainage failure) following lymph node dissection during the surgical treatment or radiation therapy of breast or pelvic cancer. The clinical problems associated with lymphedema are reduced quality of life in terms of appearance and function, as well as the development of skin ulcers, recurrent pain, and infection. Currently, countermeasures against lymphedema are mainly physical therapy such as lymphatic massage, elastic stockings, and skin care, and there is no effective and fundamental treatment with a highly recommended grade. Therefore, there is a need for the development of a fundamental novel treatment for intractable lymphedema. Therapeutic lymphangiogenesis, which has been attracting attention in recent years, is a treatment concept that reconstructs the fragmented lymphatic network to recover lymphatic vessel function and is revolutionary to be a fundamental cure. This review focuses on the translational research of therapeutic lymphangiogenesis for lymphedema and outlines the current status and prospects in the development of therapeutic applications.
The Epithelial Sodium Channel—An Underestimated Drug Target
Authors: Lemmens-Gruber Rosa , Tzotzos Susan
Published: April 2023

Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical pathways and as such are involved in several disease states. Dependent on site and type of mutation, gain- or loss-of-function generated symptoms occur which span from asymptomatic to life-threatening disorders such as Liddle syndrome, cystic fibrosis or generalized pseudohypoaldosteronism type 1. Variants of ENaC which are implicated in disease assist further understanding of their molecular mechanisms in order to create models for specific pharmacological targeting. Identification and characterization of ENaC modifiers not only furthers our basic understanding of how these regulatory processes interact, but also enables discovery of new therapeutic targets for the disease conditions caused by ENaC dysfunction. Numerous test compounds have revealed encouraging results in vitro and in animal models but less in clinical settings. The EMA- and FDA-designated orphan drug solnatide is currently being tested in phase 2 clinical trials in the setting of acute respiratory distress syndrome, and the NOX1/ NOX4 inhibitor setanaxib is undergoing clinical phase 2 and 3 trials for therapy of primary biliary cholangitis, liver stiffness, and carcinoma. The established ENaC blocker amiloride is mainly used as an add-on drug in the therapy of resistant hypertension and is being studied in ongoing clinical phase 3 and 4 trials for special applications. This review focuses on discussing some recent developments in the search for novel therapeutic agents.
Prominent Roles and Conflicted Attitudes of Eumelanin in the Living World
Authors: Terranova Maria Letizia
Published: April 2023

Eumelanin, a macromolecule widespread in all the living world and long appreciated for its protective action against harmful UV radiation, is considered the beneficial component of the melanin family (ευ means good in ancient Greek). This initially limited picture has been rather recently extended and now includes a variety of key functions performed by eumelanin in order to support life also under extreme conditions. A lot of still unexplained aspects characterize this molecule that, in an evolutionary context, survived natural selection. This paper aims to emphasize the unique characteristics and the consequent unusual behaviors of a molecule that still holds the main chemical/physical features detected in fossils dating to the late Carboniferous. In this context, attention is drawn to the duality of roles played by eumelanin, which occasionally reverses its functional processes, switching from an anti-oxidant to a pro-oxidant behavior and implementing therefore harmful effects.
Inflammaging and Immunosenescence as Part of Skin Aging—A Narrative Review
Authors: Pająk Justyna , Nowicka Danuta , Szepietowski Jacek C.
Published: April 2023

Inflammaging and immunosenescence are associated with aging of the human body, but there are key differences between them. Immunosenescence aims to adapt the body systems to aging, while inflammaging is considered a consequence of immunosenescence. There has been much research in the area of immunosenescence and inflammaging recently, yet our understanding of aging and the ability to develop interventions to decrease the harmful effect of aging on the human body is insufficient. This review is focused on immunosenescence and inflammaging processes in the skin. We aimed to identify factors that influence inflammaging, skin aging, and their mechanisms. We discussed the role of triggering factors (e.g., UV radiations, changes in bioavailability of nitric oxide, senescence-associated secretory phenotype factors, and reactive oxygen species) and inhibiting factors that can potentially be used as anti-aging treatments, as well as the idea of geroprotectors and senotherapeutics. We concluded that while knowledge on external factors can help people to improve their health conditions, knowledge on biochemical factors can help researchers to understand inflammaging process and develop interventions to minimize the impact of aging on the human body. Further research is needed to better understand the role of factors that can slow down or accelerate inflammaging.
Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
Authors: Abramiuk Monika , Frankowska Karolina , Kułak Krzysztof , Tarkowski Rafał , Mertowska Paulina , Mertowski Sebastian , Grywalska Ewelina
Published: April 2023

The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and peritoneal fluid levels of urocortin 1 (Ucn1) in patients with EMS and healthy women. Moreover, considering the immune background of the disease, the association between Ucn1 and several immune parameters was studied in both groups. We found that the serum Ucn1 level was significantly upregulated in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels tended to correspond with more advanced stages of the disease (p = 0.031). Receiver operating characteristic (ROC) analysis revealed that based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from among other EMS types. Together, these results indicate Ucn1 as a possible promising biomarker of EMS: however, not in isolation, but rather to enhance the effectiveness of other diagnostic methods.
Fatty Liver Disease, Metabolism and Alcohol Interplay: A Comprehensive Review
Authors: Odriozola Aitor , Santos-Laso Alvaro , del Barrio María , Cabezas Joaquín , Iruzubieta Paula , Arias-Loste María Teresa , Rivas Coral , Duque Juan Carlos Rodríguez , Antón Ángela , Fábrega Emilio , Crespo Javier
Published: April 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, and its incidence has been increasing in recent years because of the high prevalence of obesity and metabolic syndrome in the Western population. Alcohol-related liver disease (ArLD) is the most common cause of cirrhosis and constitutes the leading cause of cirrhosis-related deaths worldwide. Both NAFLD and ArLD constitute well-known causes of liver damage, with some similarities in their pathophysiology. For this reason, they can lead to the progression of liver disease, being responsible for a high proportion of liver-related events and liver-related deaths. Whether ArLD impacts the prognosis and progression of liver damage in patients with NAFLD is still a matter of debate. Nowadays, the synergistic deleterious effect of obesity and diabetes is clearly established in patients with ArLD and heavy alcohol consumption. However, it is still unknown whether low to moderate amounts of alcohol are good or bad for liver health. The measurement and identification of the possible synergistic deleterious effect of alcohol consumption in the assessment of patients with NAFLD is crucial for clinicians, since early intervention, advising abstinence and controlling cardiovascular risk factors would improve the prognosis of patients with both comorbidities. This article seeks to perform a comprehensive review of the pathophysiology of both disorders and measure the impact of alcohol consumption in patients with NAFLD.
A Review of Novel Strategies for Human Periodontal Ligament Stem Cell Ex Vivo Expansion: Are They an Evidence-Based Promise for Regenerative Periodontal Therapy?
Authors: Di Vito Anna , Bria Jessica , Antonelli Alessandro , Mesuraca Maria , Barni Tullio , Giudice Amerigo , Chiarella Emanuela
Published: April 2023

Periodontitis is a gingiva disease sustained by microbially associated and host-mediated inflammation that results in the loss of the connective periodontal tissues, including periodontal ligament and alveolar bone. Symptoms include swollen gingiva, tooth loss and, ultimately, ineffective mastication. Clinicians utilize regenerative techniques to rebuild and recover damaged periodontal tissues, especially in advanced periodontitis. Human periodontal ligament stem cells (hPDLSCs) are considered an appealing source of stem cells for regenerative therapy in periodontium. hPDLSCs manifest the main properties of mesenchymal stem cells, including the ability to self-renew and to differentiate in mesodermal cells. Significant progress has been made for clinical application of hPDLSCs; nevertheless, some problems remain, including the small number of cells isolated from each sample. In recent decades, hPDLSC ex vivo expansion and differentiation have been improved by modifying cell culture conditions, especially with the supplementation of cytokines’ or growth factors’ mix, chemicals, and natural compounds, or by using the decellularized extracellular matrix. Here, we analyzed the changes in stemness properties and differentiation potential of hPDLSCs when culturing in alternative media. In addition, we focused on the possibility of replacing FBS with human emoderivates to minimize the risks of xenoimmunization or zoonotic transmission when cells are expanded for therapeutic purposes.
Molecular Basis and Advances in Targeted Immunotherapy for Cancer
Authors: Macciò Antonio , Madeddu Clelia
Published: April 2023

Researchers have long attempted to stimulate the immune system of cancer patients as a therapeutic strategy [...]
Deciphering the Relationship between SARS-CoV-2 and Cancer
Authors: Costanzo Michele , De Giglio Maria Anna Rachele , Roviello Giovanni Nicola
Published: April 2023

Some viruses are known to be associated with the onset of specific cancers. These microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer cells by modulating the central metabolic pathways or hampering genomic integrity mechanisms, consequently inhibiting the apoptotic machinery and/or enhancing cell proliferation. Seven oncogenic viruses are known to promote tumorigenesis in humans: human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), Epstein-Barr virus (EBV), human T-cell leukemia virus 1 (HTLV-1), Kaposi sarcoma-associated herpesvirus (KSHV), and Merkel cell polyomavirus (MCPyV). Recent research indicates that SARS-CoV-2 infection and COVID-19 progression may predispose recovered patients to cancer onset and accelerate cancer development. This hypothesis is based on the growing evidence regarding the ability of SARS-CoV-2 to modulate oncogenic pathways, promoting chronic low-grade inflammation and causing tissue damage. Herein, we summarize the main relationships known to date between virus infection and cancer, providing a summary of the proposed biochemical mechanisms behind the cellular transformation. Mechanistically, DNA viruses (such as HPV, HBV, EBV, and MCPyV) encode their virus oncogenes. In contrast, RNA viruses (like HCV, HTLV-1) may encode oncogenes or trigger host oncogenes through cis-/-trans activation leading to different types of cancer. As for SARS-CoV-2, its role as an oncogenic virus seems to occur through the inhibition of oncosuppressors or controlling the metabolic and autophagy pathways in the infected cells. However, these effects could be significant in particular scenarios like those linked to severe COVID-19 or long COVID. On the other hand, looking at the SARS-CoV-2─cancer relationship from an opposite perspective, oncolytic effects and anti-tumor immune response were triggered by SARS-CoV-2 infection in some cases. In summary, our work aims to recall comprehensive attention from the scientific community to elucidate the effects of SARS-CoV-2 and, more in general, β-coronavirus infection on cancer susceptibility for cancer prevention or supporting therapeutic approaches.
Dexmedetomidine Protects Cerebellar Neurons against Hyperoxia-Induced Oxidative Stress and Apoptosis in the Juvenile Rat
Authors: Puls Robert , von Haefen Clarissa , Bührer Christoph , Endesfelder Stefanie
Published: April 2023

The risk of oxidative stress is unavoidable in preterm infants and increases the risk of neonatal morbidities. Premature infants often require sedation and analgesia, and the commonly used opioids and benzodiazepines are associated with adverse effects. Impairment of cerebellar functions during cognitive development could be a crucial factor in neurodevelopmental disorders of prematurity. Recent studies have focused on dexmedetomidine (DEX), which has been associated with potential neuroprotective properties and is used as an off-label application in neonatal units. Wistar rats (P6) were exposed to 80% hyperoxia for 24 h and received as pretreatment a single dose of DEX (5µg/kg, i.p.). Analyses in the immature rat cerebellum immediately after hyperoxia (P7) and after recovery to room air (P9, P11, and P14) included examinations for cell death and inflammatory and oxidative responses. Acute exposure to high oxygen concentrations caused a significant oxidative stress response, with a return to normal levels by P14. A marked reduction of hyperoxia-mediated damage was demonstrated after DEX pretreatment. DEX produced a much earlier recovery than in controls, confirming a neuroprotective effect of DEX on alterations elicited by oxygen stress on the developing cerebellum.
GSPE Pre-Treatment Exerts Long-Lasting Preventive Effects against Aging-Induced Changes in the Colonic Enterohormone Profile of Female Rats
Authors: Miguéns-Gómez Alba , Sierra-Cruz Marta , Blay M. Teresa , Rodríguez-Gallego Esther , Beltrán-Debón Raúl , Terra Ximena , Pinent Montserrat , Ardévol Anna
Published: April 2023

The impact that healthy aging can have on society has raised great interest in understanding aging mechanisms. However, the effects this biological process may have on the gastrointestinal tract (GIT) have not yet been fully described. Results in relation to changes observed in the enteroendocrine system along the GIT are controversial. Grape seed proanthocyanidin extracts (GSPE) have been shown to protect against several pathologies associated with aging. Based on previous results, we hypothesized that a GSPE pre-treatment could prevent the aging processes that affect the enteroendocrine system. To test this hypothesis, we treated 21-month-old female rats with GSPE for 10 days. Eleven weeks after the treatment, we analyzed the effects of GSPE by comparing these aged animals with young animals. Aging induced a greater endocrine response to stimulation in the upper GIT segments (cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1)), a decrease in the mRNA abundance of GLP-1, peptide YY (PYY) and chromogranin A (ChgA) in the colon, and an increase in colonic butyrate. GSPE-treated rats were protected against a decrease in enterohormone expression in the colon. This effect is not directly related to the abundance of microbiome or short-chain fatty acids (SCFA) at this location. GSPE may therefore be effective in preventing a decrease in the colonic abundance of enterohormone expression induced by aging.
On the Soundness of XAI in Prognostics and Health Management (PHM)
Authors: Solís-Martín David , Galán-Páez Juan , Borrego-Díaz Joaquín
Published: April 2023

The aim of predictive maintenance, within the field of prognostics and health management (PHM), is to identify and anticipate potential issues in the equipment before these become serious. The main challenge to be addressed is to assess the amount of time a piece of equipment will function effectively before it fails, which is known as remaining useful life (RUL). Deep learning (DL) models, such as Deep Convolutional Neural Networks (DCNN) and Long Short-Term Memory (LSTM) networks, have been widely adopted to address the task, with great success. However, it is well known that these kinds of black box models are opaque decision systems, and it may be hard to explain their outputs to stakeholders (experts in the industrial equipment). Due to the large number of parameters that determine the behavior of these complex models, understanding the reasoning behind the predictions is challenging. This paper presents a critical and comparative revision on a number of explainable AI (XAI) methods applied on time series regression models for PM. The aim is to explore XAI methods within time series regression, which have been less studied than those for time series classification. This study addresses three distinct RUL problems using three different datasets, each with its own unique context: gearbox, fast-charging batteries, and turbofan engine. Five XAI methods were reviewed and compared based on a set of nine metrics that quantify desirable properties for any XAI method. One of the metrics introduced in this study is a novel metric. The results show that Grad-CAM is the most robust method, and that the best layer is not the bottom one, as is commonly seen within the context of image processing.
The Process of Identifying Automobile Joint Failures during the Operation Phase: Data Analytics Based on Association Rules
Authors: Buyvol Polina , Makarova Irina , Voroshilov Aleksandr , Krivonogova Alla
Published: April 2023

The increasing complexity of vehicle design, the use of new engine types and fuels, and the increasing intelligence of automobiles are making it increasingly difficult to ensure trouble-free operation. Finding faulty parts quickly and accurately is becoming increasingly difficult, as the diagnostic process requires analyzing a great amount of information. Therefore, we propose an approach based on association rules, a machine learning technique, to simplify the defect detection process. To facilitate its use in a real repair company environment, we have developed a web service that allows a repairman to simultaneously identify nodes with a high probability of failure. We have described the structure and working principles of the developed web service, as well as the procedure for its application, which resulted in the discovery of several useful non-trivial rules. We have presented several rules resulting from the use of this interactive tool, which allow repairers to detect possible defects in the relevant components, during the diagnostic process, quickly and easily. These rules are also well supported and can be used by procurement departments to make tactical decisions when selecting the most promising suppliers and manufacturers. The methodology developed allows the evaluation of the effectiveness of changes in the design and technology for the manufacture and operation of individual vehicle components, analyzing the change in the composition of parts combinations over time.
Foraging Behavior of Two Pollen Wasp Species of the Genus Celonites Latreille, 1802 (Hymenoptera: Vespidae: Masarinae), from the Altai Mountains
Authors: Fateryga Alexander V. , Mauss Volker , Proshchalykin Maxim Yu.
Published: April 2023

Celonites kozlovi Kostylev, 1935, and C. sibiricus Gusenleitner, 2007, coexist in semi-deserts of the Altai Mountains. The trophic relationships of these pollen wasp species to flowers are largely unknown. We observed the flower visits and behaviors of wasps on flowers; pollen-collecting structures of females were studied using SEM; the taxonomic position of these two species was ascertained with the barcoding sequence of the mitochondrial COI-5P gene. Celonites kozlovi and C. sibiricus form a clade together with C. hellenicus Gusenleitner, 1997, and C. iranus Gusenleitner, 2018, within the subgenus Eucelonites Richards, 1962. Celonites kozlovi is polylectic in the narrow sense, collecting pollen from flowers of plants belonging to five families (with the predomination of Asteraceae and Lamiaceae) using diverse methods for both pollen and nectar uptake. In addition, this species is a secondary nectar robber, which has not been observed in pollen wasps before. The generalistic foraging strategy of C. kozlovi is correlated with an unspecialized pollen-collecting apparatus on the fore-tarsi. In contrast, C. sibiricus is broadly oligolectic, predominantly collecting pollen from flowers of Lamiaceae. Its specialized foraging strategy is associated with apomorphic behavioral and morphological traits, particularly specialized pollen-collecting setae on the frons, which enable indirect pollen uptake using nototribic anthers. These adaptations in C. sibiricus evolved independently of similar specializations in the Celonites abbreviatus-complex. Celonites kozlovi is re-described, and males are described for the first time.
Prognostic Impact of the Early Use of Tolvaptan in Elderly Patients with Acute Decompensated Heart Failure
Authors: Okada Tomoaki , Miyoshi Toru , Oka Akihiro , Tsushima Ryu , Sudo Yuya , Seiyama Kosuke , Takagi Wataru , Kawaguchi Tomohiro , Ozaki Masatomo , Sogo Masahiro , Ugawa Satoko , Nosaka Kazumasa , Takahashi Masahiko , Okawa Keisuke , Doi Masayuki
Published: April 2023

The number of elderly patients with acute decompensated heart failure (ADHF) is increasing, and it is often difficult to treat. This study aimed to evaluate the efficacy and safety of using tolvaptan early after hospitalization in elderly patients with ADHF and the prognosis one year after hospitalization. This study enrolled 185 patients with ADHF who were admitted for the first time. Tolvaptan was administered within 24 h after admission. These patients were assigned to two groups: over 80 years old (n = 109) and under 80 years old (n = 76). There were no significant differences between the two groups in the occurrence of MACCE within one year (25% vs. 20%, p = 0.59). All-cause mortality was significantly higher in the over-80 group (12% vs. 2%, p = 0.01). There were no significant differences in the incidence of worsening renal failure (11% vs. 7%, p = 0.46) and hypernatremia (5% vs. 9%, p = 1.0), and in the duration of hospitalization (19.2 days vs. 18.8 days, p = 0.8). Tolvaptan might be effective and safe in elderly patients with ADHF, and there was no difference in the incidence of MACCE within one year.
Mechanical Surface Treatments for Controlling Surface Integrity and Corrosion Resistance of Mg Alloy Implants: A Review
Authors: Santos Vincent , Uddin Mohammad , Hall Colin
Published: April 2023

The present paper aims to provide an overview of the current state-of-the-art mechanical surface modification technologies and their response in terms of surface roughness, surface texture, and microstructural change due to cold work-hardening, affecting the surface integrity and corrosion resistance of different Mg alloys. The process mechanics of five main treatment strategies, namely, shot peening, surface mechanical attrition treatment, laser shock peening, ball burnishing, and ultrasonic nanocrystal surface modification, were discussed. The influence of the process parameters on plastic deformation and degradation characteristics was thoroughly reviewed and compared from the perspectives of surface roughness, grain modification, hardness, residual stress, and corrosion resistance over short- and long-term periods. Potential and advances in new and emerging hybrid and in-situ surface treatment strategies were comprehensively eluded and summarised. This review takes a holistic approach to identifying the fundamentals, pros, and cons of each process, thereby contributing to bridging the current gap and challenge in surface modification technology for Mg alloys. To conclude, a brief summary and future outlook resulting from the discussion were presented. The findings would offer a useful insight and guide for researchers to focus on developing new surface treatment routes to resolve surface integrity and early degradation problems for successful application of biodegradable Mg alloy implants.
Class AB Voltage Follower and Low-Voltage Current Mirror with Very High Figures of Merit Based on the Flipped Voltage Follower
Authors: Ramírez-Angulo Jaime , Paul Anindita , Gangineni Manaswini , Hinojo-Montero Jose Maria , Huerta-Chua Jesús
Published: April 2023

The application of the flipped voltage follower to implement two high-performance circuits is presented: (1) The first is a class AB cascode flipped voltage follower that shows an improved slew rate and an improved bandwidth by very large factors and that has a higher output range than the conventional flipped voltage follower. It has a small signal figure of merit FOMSS = 46 MHz pF/µW and a current efficiency figure of merit FOMCE = 118. This is achieved by just introducing an additional output current sourcing PMOS transistor (P-channel Metal Oxide Semiconductor Field Effect Transistor) that provides dynamic output current enhancement and increases the quiescent power dissipation by less than 10%. (2) The other is a high-performance low-voltage current mirror with a nominal gain accuracy better than 0.01%, 0.212 Ω input resistance, 112 GΩ output resistance, 1 V supply voltage requirements, 0.15 V input, and 0.2 V output compliance voltages. These characteristics are achieved by utilizing two auxiliary amplifiers and a level shifter that increase the power dissipation just moderately. Post-layout simulations verify the performance of the circuits in a commercial 180 nm CMOS (Complementary Metal Oxide Semiconductor) technology.
Numerical Investigation on the Ventilated Supercavity around a Body under Free Surface Effect
Authors: Zhi Yuchang , Zhan Jiemin , Huang Renfang , Wang Yiwei , Li Ning
Published: April 2023

Reducing vessel resistance by using ventilated cavities has been a highly researched topic in the marine industry. There is limited literature on ventilated supercavities near the free surface, which indicates that their dynamic behavior is more complex than conventional ventilated cavities due to the effect of the free surface. This paper employs numerical simulations to study the dynamic behavior of the ventilated supercavity, taking into account the effect of the free surface. Numerical simulations can predict gas leakage behaviors, cavity geometry, and internal flow structures. The influence of the free surface shortens the length of the ventilated cavity and increases the diameter. The presence of the free surface mainly changes the vertical velocity distribution between the free surface and the cavity. The results show that there are two typical gas leakage mechanisms under different immersion depths: twin-vortex tube leakage mode and re-entrant jet leakage mode. The internal flow field of ventilated supercavity is classified into three regions: the internal boundary layer, the ventilation influence region, and the reverse flow region. As the distance between the free surface and the ventilated supercavity decreases, the ventilated supercavity is affected by both the free surface effect and the gravity effect.
Toward an Astrochronology-Based Age-Model for a Messinian Pre-Evaporitic Succession: The Example of Torrente Vaccarizzo Section in Sicily (Italy)
Authors: Maniscalco Rosanna , Forzese Martina , Barbagallo Viviana , Borzì Laura , D’Andrea Natale Maria , Distefano Salvatore , Giustolisi Chiara , Nádudvari Ádam , Pellegrino Alessandra Giovanna , Foresi Luca Maria , Di Stefano Agata
Published: April 2023

Tectonic, paleoenvironmental, and paleoclimatic unstable conditions preceding the onset of the Messinian Salinity Crisis (MSC) highly affected marine life. Changes in calcareous plankton association are overall registered in the Mediterranean. They consist of a general transition from abundant and well-diversified planktonic associations to strictly oligotypic assemblages that precede their total disappearance at the onset of evaporitic precipitation. In this work, an accurate quantitative analysis of calcareous plankton, both foraminifers and nannofossils, has been carried out in the Torrente Vaccarizzo Section of Sicily (southern Italy). The aim is to independently define a chronostratigraphic pattern of bioevents preceding the MSC in the absence of magnetostratigraphic or radiometric constraints. The fluctuating abundance of the genus Orbulina fits well with the 100 ky Eccentricity maxima, and it is successfully applied to build an astronomically calibrated age-model for the section. On this basis, all the biohorizons have been recalibrated and discussed with regard to the previous literature. Abundant influxes of selected species demonstrated to be of local significance since they are highly affected by paleoenvironmental and paleoclimatic conditions. A chronological sequence of foraminifer and nannofossil events marks the onset of the MSC with a derived age of 5.957 My, which agrees well with previous findings from other Mediterranean sections. This methodology and the new biostratigraphic events may be useful for future studies on pre-evaporitic successions of the Mediterranean.
Effect of Aging on Healing Capacity of Bituminous Composites Containing Polyphosphoric Acid
Authors: Li Mingxia , Fini Elham , Jia Xiaomin , Song Baiyang , Wang Yanhong
Published: April 2023

This study examines how aging affects the healing capacity of bituminous composites containing polyphosphoric acid (PPA). PPA is commonly used in bituminous composites to enhance its elasticity, however, PPA effectiveness highly depends on other constituents on the matrix and the environmental (internal and external) factors. In terms of internal factors, the interplay between PPA and various bitumen modifiers have been extensively studied. Here, we study how external factors such as exposure to ultraviolet radiation affect PPA’s efficacy, measured in terms of change in bitumen’s healing index. The study results showed that the introduction of PPA to bituminous composites significantly increases the bitumen healing index, however, the change in the healing index becomes less pronounced as aging progresses. The presence of additives such as taconite were found to affect the effect of PPA on bitumen’s healing index. For instance, bitumens containing 30% taconite showed the highest increase in their healing index in the presence of PPA among studied scenarios. Overall, bitumen containing PPA had a higher healing index than those without PPA regardless of the extent of aging and dosage of modifiers. This, in turn, indicates that PPA is highly effective for enhancing bitumen healing. This can be attributed to the role of PPA in promoting intermolecular interactions within the bitumen matrix.
On the Thermal Behavior during Spatial Anisotropic Femtoseconds Laser-DNA Interaction: The Crucial Role of Hermite Polynomials
Authors: Oane Mihai , Mihailescu Cristian Nicolae , Trefilov Alexandra Maria Isabel
Published: April 2023

A novel analytical formalism based on the quantum heat transport equation is proposed for the interaction of fs-laser pulses with deoxyribonucleic acid (DNA) strands. The formalism has the intensity of the laser beam and the interaction time between the laser and the DNA as input parameters. To this end, the thermal distribution generated in the irradiated DNA strands was introduced by splitting the laser beam into transverse Hermite-Gauss modes. To achieve this goal, a new powerful mathematical model was developed and applied. Fluctuations in laser intensity were taken into account by modeling them as superpositions of Hermite-Gauss laser modes. These analyses were carried out for a laser pulse duration of 100 fs, where a tiny heat-affected zone is expected, with positive predicted effects on the stability and repeatability of this technology. The main conclusion is that the laser beam spatial distribution intensity plays an essential role in the generation of the shape and magnitude of the thermal field at the junction of the irradiated DNA strands. The model may prove useful in modeling laser beam processing under significant intensity fluctuations. There are at least two main areas of application for the present model of heat transfer from laser to DNA: (i) the study of DNA elongation without destroying the target information (for a sample temperature variation lower than 10 K; in the case of H[1,y]); and (ii) cancer treatment (especially of skin tissue), where we should obtain a temperature variation higher than 10 K (but lower than 30 K; in the case of H[2,y], H[4,y]), in order to eradicate the diseased cells.
Biopotentials of Collagen Scaffold Impregnated with Plant-Cell-Derived Epidermal Growth Factor in Defective Bone Healing
Authors: Poudel Sher Bahadur , Bhattarai Govinda , Kwon Tae-Ho , Lee Jeong-Chae
Published: April 2023

The combination of scaffolds with recombinant human epidermal growth factor (rhEGF) protein can enhance defective bone healing via synergistic activation to stimulate cellular growth, differentiation, and survival. We examined the biopotentials of an rhEGF-loaded absorbable collagen scaffold (ACS) using a mouse model of calvarial defects, in which the rhEGF was produced from a plant cell suspension culture system because of several systemic advantages. Here, we showed a successful and large-scale production of plant-cell-derived rhEGF protein (p-rhEGF) by introducing an expression vector that cloned with its cDNA under the control of rice α-amylase 3D promoter into rice calli (Oryza sativa L. cv. Dongjin). Implantation with p-rhEGF (5 μg)-loaded ACSs into critical-sized calvarial defects enhanced new bone formation and the expression of osteoblast-specific markers in the defected regions greater than implantation with ACSs alone did. The potency of p-rhEGF-induced bone healing was comparable with that of Escherichia coli-derived rhEGF protein. The exogenous addition of p-rhEGF increased the proliferation of human periodontal ligament cells and augmented the induction of interleukin 8, bone morphogenetic protein 2, and vascular endothelial growth factor in the cells. Collectively, this study demonstrates the successful and convenient production of p-rhEGF, as well as its potency to enhance ACS-mediated bone regeneration by activating cellular responses that are required for wound healing.
High-Temperature Behaviour of Zn-Based Galvannealed Coatings on Steel
Authors: Gogola Peter , Gabalcová Zuzana , Kusý Martin , Ptačinová Jana
Published: April 2023

The potential of using a Zn-based, hot-dip coating to limit steel scale formation was investigated. The phase evolution within a pure Zn and a Zn0.1Al coating on a medium-carbon (0.5 wt.% C, 0.25 wt.% Si) steel sheet during a series of heat treatment steps was investigated. Such Zn-based coatings react with the steel substrate depending on the actual heat treatment condition. A series of expected intermetallic phases was observed via SEM/EDX and XRD techniques, such as ζ, δ and Γ phases along the η(Zn) phase. The η(Zn) phase was transformed to mainly δ and Γ phases during galvannealing (500 °C). The rapid quenching from 850 °C enabled the formation of the supersaturated α-(Fe) solid solution with increased Zn content. A continuous, intact, ~20 µm thick coating was observed after the final step of the heat treatment procedure, while signs of liquid metal embrittlement (LME) were not observed near the coating/steel interface. This will ensure reliable protection against heavy scale formation on heat-treated steel parts.
Role of Doping Effect and Chemical Pressure Effect Introduced by Alkali Metal Substitution on 1144 Iron-Based Superconductors
Authors: Huang Yi-Na , Yu Xiang-Long , Liu Da-Yong , Han Miao-Miao
Published: April 2023

CaAFe4As4 with A = K, Rb, and Cs are close to the doped 122 system, and the parent material can reach a superconducting transition temperature of 31–36 K without doping. To study the role of alkali metals, we investigated the induced hole doping and chemical pressure effects as a result of the introduction of alkali metals using density-functional-based methods. These two effects can affect the superconducting transition temperature by changing the number of electrons and the structure of the FeAs conductive layer, respectively. Our study shows that the dxz and dyz orbitals, which are degenerate in CaFe2As2, become nondegenerate in CaAFe4As4 due to two nonequivalent arsenic atoms (As1 and As2). The unusual oblate ellipsoid hole pocket at Γ point in CaAFe4As4 results from a divalent cation Ca2+ replaced by a monovalent cation A+. It shows one of the main differences in fermiology compared to a particular form of CaFe2As2 with reduced 1144 symmetry, due to the enhancement of As2-Fe hybridization. The unusual band appears in CaFe2As2 (1144) and gradually disappears in the change of K to Cs. Further analysis shows that this band is contributed by As1 and has strong dispersion perpendicular to the FeAs layer, suggesting that it is related to the peculiar van Hove singularity below the Fermi level. In addition, various aspects of CaFe2As2 (1144) and CaAFe4As4 in the ground state are discussed in terms of the influence of hole doping and chemical pressure.
Subroutine Embedding and Finite Element Simulation of the Improved Constitutive Equation for Ti6Al4V during High-Speed Machining
Authors: Liu Lijuan , Wu Wenge , Zhao Yongjuan , Cheng Yunping
Published: April 2023

The Johnson–Cook (J–C) constitutive model is not suitable for Ti-6Al-4V alloy in the high-speed cutting finite element simulation, as it has no response dynamic recrystallization softening effect under heavy impact and high temperature. In this paper, an improved constitutive model considering the recrystallization effect was established, and the parameters were fitted with the data of flow stress–strain of the Split Hopkinson Pressure Bar (SHPB) test. The relevant theories of cutting finite element simulation were studied, such as nonlinear constitutive elastic–plastic deformation, strain state, and material yield. A subroutine that included the Recht shear failure instability criterion and the improved model was coded in Fortran and embedded in the finite element simulation software AdvantEdge FEM, along with the return mapping stress integration algorithm. The simulated stress of the improved model dropped dramatically from 460 MPa to 220 MPa when the temperature rises from 950 °C to 1000 °C, and its decline reached 46.7%, while the J–C model only decreased by 10%. Comparative studies indicate that the stress change of the improved constitutive simulation is closer to the SHPB test results than the J–C constitutive, and the new one is more suitable when it expresses the high temperature and heavy impact in the high-speed milling.
A New Microarchitecture-Based Parameter to Predict the Micromechanical Properties of Bone Allografts
Authors: Xiong Zhuang , Rouquier Léa , Chappard Christine , Bachy Manon , Huang Xingrong , Potier Esther , Bensidhoum Morad , Hoc Thierry
Published: April 2023

Scaffolds are an essential component of bone tissue engineering. They provide support and create a physiological environment for cells to proliferate and differentiate. Bone allografts extracted from human donors are promising scaffolds due to their mechanical and structural characteristics. Bone microarchitecture is well known to be an important determinant of macroscopic mechanical properties, but its role at the microscopic, i.e., the trabeculae level is still poorly understood. The present study investigated linear correlations between microarchitectural parameters obtained from X-ray computed tomography (micro-CT) images of bone allografts, such as bone volume fraction (BV/TV), degree of anisotropy (DA), or ellipsoid factor (EF), and micromechanical parameters derived from micro-finite element calculations, such as mean axial strain (εz) and strain energy density (We). DAEF, a new parameter based on a linear combination of the two microarchitectural parameters DA and EF, showed a strong linear correlation with the bone mechanical characteristics at the microscopic scale. Our results concluded that the spatial distribution and the plate-and-rod structure of trabecular bone are the main determinants of the mechanical properties of bone at the microscopic level. The DAEF parameter could, therefore, be used as a tool to predict the level of mechanical stimulation at the local scale, a key parameter to better understand and optimize the mechanism of osteogenesis in bone tissue engineering.
Up to 100% Replacement of Natural Materials from Residues: Recycling Blast Furnace Slag and Fly Ash as Self-Leveling Cementitious Building Materials
Authors: Torréns-Martín David , Fernández-Carrasco Lucía J. , Blanco-Varela María Teresa
Published: April 2023

The objective of this research is to study the use in the construction industry of recycled slag (SL) and fly ash (FA) using from 0.1 to 5% calcium sulfate (wCS¯). These wastes have been used to make ternary mixture systems and evaluated in terms of technological properties as cementitious materials for building applications. Studying their micro-structure as hydration products, setting times and mechanical properties shows a way to develop new mixtures from high proportion of waste, which are alternatives to the traditional nature ternary systems: Portland cement (PC), calcium aluminate cement (CAC) and calcium sulphate (CS¯). Based on previous work with natural products, the selected SL/FA ratios were 9 and 2.3 and the sulphate contents were 0, 1 and 5%. The water/binder ratio used for these cementitious mixes was 0.4. The specimens prepared for strength determination were prisms of 10 × 10 × 60 mm. The pastes were prepared and cured at 20 °C and 98% relative humidity for 1 day and then either stored at 20 °C at 98% humidity (dry) or immersed in distilled water (wet) for 14 and 28 days. The results showed that both FA and SL mixed with CS¯ produce ettringite after 28 days of setting, and this phase was the main crystalline hydrated product in all mixes. Calcium sulphate stimulates the hydration reactions of the mixes and the strength increases when the CS¯ content is higher due to ettringite formation, while the setting time decreases, as happened in the systems prepared with natural materials.
Analysis of the Effects of an Unconventional Rolling Process under Cumulative Plastic Deformation Conditions
Authors: Pawlicki Jacek , Płachta Adam
Published: April 2023

This article presents the results of research carried out on an experimental rolling mill with axial, cyclic movement of rolls (RCMR). The device was made on the basis of an unconventional technical solution for the movement of shaping tools and equipped with a complete measuring system recording all the parameters of the process. The research was conducted on selected copper alloys CuFe2 and CuCr0.6. Rolling tests in the RCMR process were carried out for rolling speeds vr = 3.1 × 10−3, 6.3 × 10−3 and 9.4 × 10−3 m/s, which correspond to the rotational speed of the rollers at ω = 1, 2 and 3 rpm for an active diameter of the rollers = 60 mm. In testing the thermal effects of the process, the rolling speed ω = 0.7 rpm was also used. A constant value of the frequency of axial movement of the rollers f = 1 Hz and the amplitude of the displacement of the rollers A = 0.8 mm were assumed. The rolling process for the strands was carried out in six culverts using the average relative crush in the passage of Δh = 15%. Conventional rolling tests were carried out to compare rolling processes, and the obtained data formed the basis for assessing the strain intensity and identifying local deformation zones in the RCMR rolling process. The waveforms of rolling pressures, intensity and non-uniformity of deformation, and increase in the temperature of the strip surface in subsequent culverts were compared with the results obtained in the conventional rolling process.