bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary intake, physical activity and sedentary behavior and association with BMI during the transition to parenthood: a prospective dyadic study
Authors: Versele Vickà , Stas Lara , Aerenhouts Dirk , Deliens Tom , Matthys Christophe , Gucciardo Leonardo , Devlieger Roland , Clarys Peter , Bogaerts Annick
Published: June 2023

Introduction

Little is known on how diet, physical activity (PA) and sedentary behavior (SB) changes during pregnancy and after childbirth in primiparous couples. Moreover, it is unclear how potential behavioral changes are associated with changes in BMI. This study examined changes in diet, PA and SB, and their association with changes in BMI in couples transitioning to parenthood.

Methods

Dietary intake (FFQ), PA, SB (both Actigraph GT3X accelerometers) and BMI of women and men were assessed at 12 weeks of gestation, 6 weeks and 6 months postpartum. Data were analyzed using dyadic longitudinal data analyses techniques.

Results

In women, a decrease in fruit intake, an increase in alcohol intake, an increase of light-intensity PA, and a decrease in SB were observed from the beginning of pregnancy up to 6 months postpartum. Decreases in fruit intake between 6 weeks and 6 months postpartum was associated with increases in BMI. Men did not show significant dietary changes, while an increase in light-intensity PA and a decrease in moderate-to-vigorous PA (MVPA) was observed at 6 months postpartum when compared to 12 weeks of gestation. Paternal increases in “avoidance food group” intake were associated with increases in BMI between baseline and 6 weeks postpartum. No associations of changes in BMI and changes in PA and SB were found.

Discussion

Not only mothers but also fathers experienced unfavorable changes in lifestyle during the transition to parenthood, with impact on BMI changes. This highlights the need to monitor unhealthy changes in lifestyle and body weight in both parents when expecting a child and after childbirth.

Clinical trial registration

Clinicaltrials.gov, NCT03454958.
Native opportunities to stop hypertension: study protocol for a randomized controlled trial among urban American Indian and Alaska Native adults with hypertension
Authors: Sinclair Ka’imi , Nguyen Cassandra J. , Wetherill Marianna S. , Nelson Katie , Jackson Alexandra M. , Taniguchi Tori , Jernigan Valarie Blue Bird , Buchwald Dedra
Published: June 2023

Introduction

American Indian and Alaska Native (AI/AN) adults experience disproportionate cardiovascular disease (CVD) morbidity and mortality compared to other races, which may be partly attributable to higher burden of hypertension (HTN). Dietary Approaches to Stop Hypertension (DASH) is a high-impact therapeutic dietary intervention for primary and secondary prevention of CVD that can contribute to significant decreases in systolic blood pressure (BP). However, DASH-based interventions have not been tested with AI/AN adults, and unique social determinants of health warrant independent trials. This study will assess the effectiveness of a DASH-based intervention, called Native Opportunities to Stop Hypertension (NOSH), on systolic BP among AI/AN adults in three urban clinics.

Methods

NOSH is a randomized controlled trial to test the effectiveness of an adapted DASH intervention compared to a control condition. Participants will be aged ≥18 years old, self-identify as AI/AN, have physician-diagnosed HTN, and have elevated systolic BP (≥ 130 mmHg). The intervention includes eight weekly, tailored telenutrition counseling sessions with a registered dietitian on DASH eating goals. Intervention participants will be provided $30 weekly and will be encouraged to purchase DASH-aligned foods. Participants in the control group will receive printed educational materials with general information about a low-sodium diet and eight weekly $30 grocery orders. All participants will complete assessments at baseline, after the 8-week intervention, and again 12 weeks post-baseline. A sub-sample of intervention participants will complete an extended support pilot study with assessments at 6- and 9-months post-baseline. The primary outcome is systolic BP. Secondary outcomes include modifiable CVD risk factors, heart disease and stroke risk scores, and dietary intake.

Discussion

NOSH is among the first randomized controlled trials to test the impact of a diet-based intervention on HTN among urban AI/AN adults. If effective, NOSH has the potential to inform clinical strategies to reduce BP among AI/AN adults.

Clinical trials registration

https://clinicaltrials.gov/ct2/show/NCT02796313, Identifier NCT02796313.
A global analysis of COVID-19 infection fatality rate and its associated factors during the Delta and Omicron variant periods: an ecological study
Authors: Thi Hong Nguyen Nhi , Ou Tsong-Yih , Huy Le Duc , Shih Chung-Liang , Chang Yao-Mao , Phan Thanh-Phuc , Huang Chung-Chien
Published: June 2023

Background

The Omicron variant of SARS-CoV-2 is more highly infectious and transmissible than prior variants of concern. It was unclear which factors might have contributed to the alteration of COVID-19 cases and deaths during the Delta and Omicron variant periods. This study aimed to compare the COVID-19 average weekly infection fatality rate (AWIFR), investigate factors associated with COVID-19 AWIFR, and explore the factors linked to the increase in COVID-19 AWIFR between two periods of Delta and Omicron variants.

Materials and methods

An ecological study has been conducted among 110 countries over the first 12 weeks during two periods of Delta and Omicron variant dominance using open publicly available datasets. Our analysis included 102 countries in the Delta period and 107 countries in the Omicron period. Linear mixed-effects models and linear regression models were used to explore factors associated with the variation of AWIFR over Delta and Omicron periods.

Findings

During the Delta period, the lower AWIFR was witnessed in countries with better government effectiveness index [β = −0.762, 95% CI (−1.238)–(−0.287)] and higher proportion of the people fully vaccinated [β = −0.385, 95% CI (−0.629)–(−0.141)]. In contrast, a higher burden of cardiovascular diseases was positively associated with AWIFR (β = 0.517, 95% CI 0.102–0.932). Over the Omicron period, while years lived with disability (YLD) caused by metabolism disorders (β = 0.843, 95% CI 0.486–1.2), the proportion of the population aged older than 65 years (β = 0.737, 95% CI 0.237–1.238) was positively associated with poorer AWIFR, and the high proportion of the population vaccinated with a booster dose [β = −0.321, 95% CI (−0.624)–(−0.018)] was linked with the better outcome. Over two periods of Delta and Omicron, the increase in government effectiveness index was associated with a decrease in AWIFR [β = −0.438, 95% CI (−0.750)–(−0.126)]; whereas, higher death rates caused by diabetes and kidney (β = 0.472, 95% CI 0.089–0.855) and percentage of population aged older than 65 years (β = 0.407, 95% CI 0.013–0.802) were associated with a significant increase in AWIFR.

Conclusion

The COVID-19 infection fatality rates were strongly linked with the coverage of vaccination rate, effectiveness of government, and health burden related to chronic diseases. Therefore, proper policies for the improvement of vaccination coverage and support of vulnerable groups could substantially mitigate the burden of COVID-19.
Deep learning-based left ventricular segmentation demonstrates improved performance on respiratory motion-resolved whole-heart reconstructions
Authors: Yang Yitong , Shah Zahraw , Jacob Athira J. , Hair Jackson , Chitiboi Teodora , Passerini Tiziano , Yerly Jerome , Di Sopra Lorenzo , Piccini Davide , Hosseini Zahra , Sharma Puneet , Sahu Anurag , Stuber Matthias , Oshinski John N.
Published: June 2023

Introduction

Deep learning (DL)-based segmentation has gained popularity for routine cardiac magnetic resonance (CMR) image analysis and in particular, delineation of left ventricular (LV) borders for LV volume determination. Free-breathing, self-navigated, whole-heart CMR exams provide high-resolution, isotropic coverage of the heart for assessment of cardiac anatomy including LV volume. The combination of whole-heart free-breathing CMR and DL-based LV segmentation has the potential to streamline the acquisition and analysis of clinical CMR exams. The purpose of this study was to compare the performance of a DL-based automatic LV segmentation network trained primarily on computed tomography (CT) images in two whole-heart CMR reconstruction methods: (1) an in-line respiratory motion-corrected (Mcorr) reconstruction and (2) an off-line, compressed sensing-based, multi-volume respiratory motion-resolved (Mres) reconstruction. Given that Mres images were shown to have greater image quality in previous studies than Mcorr images, we hypothesized that the LV volumes segmented from Mres images are closer to the manual expert-traced left ventricular endocardial border than the Mcorr images.

Method

This retrospective study used 15 patients who underwent clinically indicated 1.5 T CMR exams with a prototype ECG-gated 3D radial phyllotaxis balanced steady state free precession (bSSFP) sequence. For each reconstruction method, the absolute volume difference (AVD) of the automatically and manually segmented LV volumes was used as the primary quantity to investigate whether 3D DL-based LV segmentation generalized better on Mcorr or Mres 3D whole-heart images. Additionally, we assessed the 3D Dice similarity coefficient between the manual and automatic LV masks of each reconstructed 3D whole-heart image and the sharpness of the LV myocardium-blood pool interface. A two-tail paired Student’s t-test (alpha = 0.05) was used to test the significance in this study.

Results & Discussion

The AVD in the respiratory Mres reconstruction was lower than the AVD in the respiratory Mcorr reconstruction: 7.73 ± 6.54 ml vs. 20.0 ± 22.4 ml, respectively (n = 15, p-value = 0.03). The 3D Dice coefficient between the DL-segmented masks and the manually segmented masks was higher for Mres images than for Mcorr images: 0.90 ± 0.02 vs. 0.87 ± 0.03 respectively, with a p-value = 0.02. Sharpness on Mres images was higher than on Mcorr images: 0.15 ± 0.05 vs. 0.12 ± 0.04, respectively, with a p-value of 0.014 (n = 15).

Conclusion

We conclude that the DL-based 3D automatic LV segmentation network trained on CT images and fine-tuned on MR images generalized better on Mres images than on Mcorr images for quantifying LV volumes.
The beneficial effects of curcumin supplementation on blood lipid levels among patients with metabolic related diseases in Asia area: a systematic review and meta-analysis of randomized controlled trials
Authors: Deng Zhifang , Yang Ke , Cai Xiaonan , Mei Hong , Xiao Han , Gao Wenqi
Published: June 2023

Objective

Published studies suggest that the effects of curcumin on blood lipids in adults are controversial, and it is unclear whether there is a dose response to lipid changes following curcumin supplementation. Therefore, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of curcumin on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) in the Asian populations with metabolic diseases.

Methods

We systematically searched four electronic databases, including Web of Science, PubMed, Google Scholar, and Cochrane Library, for randomized controlled trials (RCTs) of the effects of curcumin on TG, TC, LDL, and HDL in the Asian populations with metabolic diseases. Mean difference (MD) indicates effect size with combined 95% confidence interval (95% CI). Heterogeneity among studies was assessed by I2. Subgroup analyses were performed to explore potential sources of heterogeneity.

Results

Evidence from 23 RCTs for TG, 21 RCTs for TC and LDL, and 22 RCTs for HDL showed that curcumin supplementation significantly reduced TG (MD: −18.07 mg/dL, 95% CI: −30.30, −5.85, P < 0. 01), TC (MD: −13.29 mg/dL, 95% CI: −20.43, −6.16, P < 0.01), and LDL (MD: −10.44 mg/dL, 95% CI: −16.87, −4.00, P < 0.01), but no effect on HDL (MD: 1.66 mg/dL, 95% CI: −0.13, 3.44, P = 0.07). In the non-linear dose-response analysis, we observed a significant effect of curcumin supplementation dose on TG levels (P-non-linearity = 0.022).

Conclusion

In conclusion, curcumin may be beneficial in reducing TG, TC, and LDL levels in the Asian populations with metabolic diseases. The dose of curcumin intervention may be an underlying factor influencing TG levels.
Key performance indicators used by dairy consultants during the evaluation of reproductive performance during routine visits
Authors: Armengol Ramon , Fraile Lorenzo , Bach Alex
Published: June 2023

Dairy farms need thorough and efficient reproduction control. Consultants specialized in reproduction use key performance indicators (KPI) to monitor the reproductive performance of farms and must be able to decipher between the approach in a first visit and routine visits. A total of 49 consultants specialized in dairy reproduction from 21 countries responded to an online survey conducted to determine the most suitable parameters during routine visits every 2 to 4 weeks. The survey was comprised of 190 questions, 178 of them rated from 0 (irrelevant) to 10 (maximum importance) points. The questions were divided into five sections: (1) consultant and farm model, (2) general data of the farm, (3) cow reproduction, (4) postpartum and metabolic disease, and (5) heifer reproduction. The median, interquartile range, minimum and maximum values, and 95% confidence interval were determined for each question. Afterward, a multivariate analysis, using between-group linkage via Ward's hierarchical clustering was conducted to generate clusters of consultants according to their response pattern. Finally, a chi-square test was conducted to assess the association between years of experience of the consultant and farm size within the clusters generated in each section of the questionnaire. The majority of the consultants considered 34 parameters to be highly important (rated 8–10) to analyze during routine visits. The consultants used several KPI (in variable quantitative range) to evaluate any of the presented sections and considered that all the five sections are critical to control. They are aware of using KPI that reflect heat detection, fertility, and farming efficiency as well as KPI that can provide information on reproductive efficiency in the near future for cows, such as postpartum and metabolic diseases. However, parameters that are relatively old and ineffective, in terms of reproductive performance control, are still highly regarded by the majority of consultants in a routine-visit scenario. Farm size and years of experience of the consultant did not influence the type or number of parameters chosen as KPI during routine visits. The parameters rated with the highest importance (rate 10) that could be considered for an easy, fast, and universal use in routine visits to assess the reproductive status were: First service CR (%), Overall pregnancy rate (%) for cows, and age at first calving (d) for heifers.
Ventralex™ ST Hernia Patch Repair for Small Umbilical Hernia is Safe and Effective: A Retrospective Cohort Study
Authors: Hiekkaranta Juha M. , Ahonen Mirella , Mäkäräinen Elisa , Ohtonen Pasi , Saarnio Juha , Rautio Tero
Published: June 2023

Background: Hernia patches for umbilical hernia repair have gained popularity due to their short operation time and ease of use. However, up to 10% re-operation and 8% recurrence rates at 2-year follow-up have been published. This retrospective cohort study presents the long-term results of the hernia patch technique for umbilical hernia repair.

Methods: All adult patients who underwent a primary umbilical hernia repair at Oulu University Hospital hernia surgery units during 2014–2018 were included in the study. The primary outcome measure was recurrence rate. Secondary outcomes were complications and re-operation rate.

Results: A total of 619 elective primary umbilical hernia repairs were performed during 2014–2018. The major technique used was Ventralex™ ST hernia patch repair (79.0%, 488/619) for small hernias with a mean width of 1.8 (SD 0.79) cm. Most of the patches (84.7%, 414/488) were placed in the preperitoneal space. Hernia recurrence rate of patient operated on using Ventralex™ ST hernia patch was 2.5% (12/488) during a mean follow-up time of 68 (SD 16, 43–98) months. Re-operation rate for another reason than recurrence was 1.6% (8/488). Clavien-Dindo complications ≥3 occurred in 4.1% (20/488) of cases and surgical site infection rate was 3.3% (16/488).

Conclusion: Umbilical hernia repair using a Ventralex™ ST hernia patch placed in preperitoneal space have acceptable results in terms of recurrence and re-operations in this cohort study.
Delayed spontaneous remission of acquired factor V inhibitor refractory to immunosuppressive therapy with pregnancy-associated improvement
Authors: Ceglédi Andrea , Dolgos János , Fekete Mónika , Gopcsa László , Várkonyi Andrea , Vilimi Beáta , Mikala Gábor , Bodó Imre
Published: June 2023

Introduction: Acquired factor V inhibitor (AFVI) is a rare autoimmune bleeding disorder. The treatment of AFVI is challenging, and patients often require both bleeding control and inhibitor eradication.

Methods: We conducted a retrospective analysis of the medical records of a 35-year-old Caucasian woman who presented with severe AFVI-induced bleeding and subsequent immunosuppressive therapy.

Results: To provide haemostasis, rFVIIa was given with good efficacy. The patient was treated with various combinations of immunosuppressive regimens over the course of 2.5 years, including plasmapheresis plus immunoglobulins, dexamethasone + rituximab, cyclophosphamide + dexamethasone + rituximab + cyclosporine, cyclosporin + sirolimus + cyclophosphamide + dexamethasone, bortezomib + sirolimus + methylprednisolone, and sirolimus + mycophenolate mofetil. Although these treatment modalities resulted in intermittent partial reversals of AFVI over 2.5 years, eventually the inhibitor became therapy-resistant. However, following the discontinuation of all immunosuppressive therapy, the patient experienced a partial spontaneous remission, which was followed by a pregnancy. During the pregnancy, the FV activity increased to 54% and the coagulation parameters returned to normal levels. The patient underwent Caesarean section without any bleeding complications and delivered a healthy child.

Discussion: The use of an activated bypassing agent for bleeding control is effective in patients with severe AFVI. The presented case is unique because the treatment regimens included multiple combinations of immunosuppressive agents. This demonstrates that AFVI patients may undergo spontaneous remission even after multiple courses of ineffective immunosuppressive protocols. Additionally, pregnancy-associated improvement of AFVI is an important finding that warrants further investigation.
A Novel Disturbance-Free-Payload Satellite Design for High-Precision Collaborative Observation
Authors: Deng Yifan , Zhou Jiaxing , Chen Xiang , Yao Youxin , Huang Qixuan
Published: June 2023

High-precision collaborative observation is urgently needed due to the increasing demands of space science missions. Based on a conventional DFP (disturbance-free-payload) configuration, this paper presents a novel DFP that has great potential to deal with collaborative observation missions. The novel DFP system is developed, in which two or more payloads are installed via a non-contact unit and installed parallel configuration. Thus, the novel design is a multibody dynamics system. With the incorporation of the dynamics of the flexible umbilical between the PMs (payload modules) and SM (support module), the six-degrees-of-freedom multibody rigid–flexible dynamics of the whole system are derived. To verify the effectiveness of the novel DFP design in a collaborative observation mission, a multi-loop controller is designed for an inertial Earth collaborative observation mission. Simulation studies are conducted, which indicate that the proposed design can complete collaborative observation and achieve high precision.
Study of a Regional Turboprop Aircraft with Electrically Assisted Turboshaft
Authors: Habermann Anaïs Luisa , Kolb Moritz Georg , Maas Philipp , Kellermann Hagen , Rischmüller Carsten , Peter Fabian , Seitz Arne
Published: June 2023

Hybrid-Electric Propulsion (HEP) could be part of the solution to decrease emissions associated with regional commercial aviation. This study presents results for the aircraft level fuel reduction potential of a regional turboprop concept with an HEP architecture and Entry-Into-Service (EIS) in 2035+. The configuration specifically tackles the elaborated challenges of introducing an additional electrical energy source to the configuration by employing a twofold electrical assistance to a turboshaft engine in combination with an innovative thermal management concept. Relevant components and disciplines were modeled and incorporated into an integrated aircraft design environment. The behavior and interaction of the HEP architecture with the aircraft was thoroughly investigated. A best-performing configuration was derived and compared with a conventional reference configuration following a State-of-the-Art (SoA) reference aircraft approach. For a typical mission with 200 nmi range, a block fuel reduction of 9.6% was found. However, the assumed battery performance characteristics limited the reduction potential and led to a fuel burn increase for the 600 nmi design mission. Furthermore, sourcing the non-propulsive subsystems directly from the on-board battery was detrimental. The innovative Thermal Management System (TMS) located in the propeller slipstream showed a synergistic effect with the investigated configuration.
Disturbance Attenuation and Pointing Control System Design for an Improved Disturbance-Free Payload Spacecraft
Authors: Jin Ting , Kang Guohua , Cai Jian , Jia Shaoxia , Yang Jinghua , Zhang Xinghua , Zhang Zhenhua , Li Long , Liu Fangfang
Published: June 2023

The low-frequency disturbances transmitted by flexible cables are difficult to be attenuated for a novel disturbance-free payload spacecraft, which decreases the payload’s pointing accuracy and stability. In this research, a new spacecraft configuration with a high-precision inertial reference unit composed of capacitive sensors and a spherical test mass is proposed. The disturbance attenuation and pointing control system is subdivided into four interconnected control loops. The payload can be isolated from disturbances in the all-frequency band by the active vibration isolation control loop and the drag-free control loops, and its high-precision pointing requirement can be satisfied with the attitude pointing control loop and the attitude tracking control loop. An integrated control strategy is proposed, and the control system is decoupled into 12 single-input single-output control loops by pre-compensating, which lays the foundation for feedback design. Through the amplitude-frequency response analysis, the control bandwidth is designed according to the Proportional-Integral-Differentive control algorithm. The numerical simulations show that the disturbance attenuation performance is better than −20 dB in the all-frequency band, and the pointing accuracy and the pointing stability are better than 10−6 deg and 10−7 deg/s, respectively. The new spacecraft configuration and the disturbance attenuation and pointing control system provide a general technical solution for payloads with high-precision and high-stability requirements.
A Novel Zero-Truncated Katz Distribution by the Lagrange Expansion of the Second Kind with Associated Inferences
Authors: Shibu Damodaran Santhamani , Chesneau Christophe , Monisha Mohanan , Maya Radhakumari , Irshad Muhammed Rasheed
Published: June 2023

In this article, the Lagrange expansion of the second kind is used to generate a novel zero-truncated Katz distribution; we refer to it as the Lagrangian zero-truncated Katz distribution (LZTKD). Notably, the zero-truncated Katz distribution is a special case of this distribution. Along with the closed form expression of all its statistical characteristics, the LZTKD is proven to provide an adequate model for both underdispersed and overdispersed zero-truncated count datasets. Specifically, we show that the associated hazard rate function has increasing, decreasing, bathtub, or upside-down bathtub shapes. Moreover, we demonstrate that the LZTKD belongs to the Lagrangian distribution of the first kind. Then, applications of the LZTKD in statistical scenarios are explored. The unknown parameters are estimated using the well-reputed method of the maximum likelihood. In addition, the generalized likelihood ratio test procedure is applied to test the significance of the additional parameter. In order to evaluate the performance of the maximum likelihood estimates, simulation studies are also conducted. The use of real-life datasets further highlights the relevance and applicability of the proposed model.
End-to-End 3D Liver CT Image Synthesis from Vasculature Using a Multi-Task Conditional Generative Adversarial Network
Authors: Xiao Qianmu , Zhao Liang
Published: June 2023

Acquiring relevant, high-quality, and heterogeneous medical images is essential in various types of automated analysis, used for a variety of downstream data augmentation tasks. However, a large number of real image samples are expensive to obtain, especially for 3D medical images. Therefore, there is an urgent need to synthesize realistic 3D medical images. However, the existing generator models have poor stability and lack the guidance of prior medical knowledge. To this end, we propose a multi-task (i.e., segmentation task and generation task) 3D generative adversarial network (GAN) for the synthesis of 3D liver CT images (3DMT-GAN). To the best of our knowledge, this is the first application for a 3D liver CT image synthesis task. Specifically, we utilize a mask of vascular segmentation as the input because it contains structural information about a variety of rich anatomical structures. We use the semantic mask of the liver as prior medical knowledge to guide the 3D CT image generation, reducing the calculation of a large number of backgrounds, thus making the model more focused on the generation of the region of the liver. In addition, we introduce a stable multiple gradient descent algorithm (MGDA) reconstruction method into our model to balance the weights of the multi-task framework. Experiments were conducted on a real dataset, and the experimental results show that the segmentation task achieves a Dice similarity coefficient (DSC) of 0.87, while the synthesis task outperforms existing state-of-the-art methods. This study demonstrates the feasibility of using vascular images to synthesize images of the liver.
Augmented Reality and the Dematerialization of Experiential Art
Authors: Schuld Dawna
Published: June 2023

One of the most compelling effects of digitally enhanced and digitally enabled immersive exhibitions is their paradoxical dematerialization of “analog” experience. What leads exhibition visitors to accept that immersion is a state achieved only through technological mediation? Are we not already perceptually immersed in the world, as the phenomenologists asserted? This essay explores how digital enhancement disengages self-awareness by masquerading as immersion. In contrast, contemporary artists Karin Sander, Janet Cardiff, and Chris Salter employ desynchronizing and dislocating tactics to challenge naïve notions of what comprises an aesthetic experience, in order to requaint viewers with their own perceptual and ethical agency.
Impact of Spheroidization of Natural Graphite on Fast-Charging Capability of Anodes for LIB
Authors: Fischer Steffen , Doose Stefan , Müller Jannes , Höfels Christian , Kwade Arno
Published: June 2023

Despite numerous research on new active materials for anodes, graphite remains the most commonly used material in Li-ion batteries. The spherical shape of the graphite particles has proven to be beneficial for application in electric vehicles, especially for fast charging. So far, the spheroidization of natural flake graphite is conducted by a rigid and inefficient cascade process. In this work, a scalable classifier system was used for spheroidization, and it was demonstrated that a spheroidization time of 15 min is sufficient to improve material properties and enhance electrochemical performance while maintaining high process yields of 55%. Insights into the influence of the morphology on the intrinsic and structural properties of the graphite particles and manufactured electrodes are provided. Spheroidization creates a more efficient pore network in the coating layer while reducing the internal resistance and increasing the surface area of the particles by a factor of 1.8. We demonstrate that the spherical shape improves the discharge rate capability by 1.8, and the specific charge capacity could be enhanced by more than 237% at a C-rate of 3. An additional carbon coating could significantly decrease the specific surface area and increase the specific capacity at high C-rates.
MOF–Derived N–Doped C @ CoO/MoC Heterojunction Composite for Efficient Oxygen Reduction Reaction and Long-Life Zn–Air Battery
Authors: Yin Ruilian , Ma Suli , Ying Jiaping , Lu Zhentao , Niu Xinxin , Feng Jinxiu , Xu Feng , Zheng Yifan , Liu Wenxian , Cao Xiehong
Published: June 2023

The high activity and reliability of bifunctional oxygen catalysts are imperative for rechargeable metal–air batteries. However, the preparation of bifunctional non–noble metal electrocatalysts with multiple active sites remains a great challenge. Herein, an MOF–derived N–doped C–loaded uniformly dispersed CoO/MoC heterojunction catalyst for high–performance dual function was prepared by a simple “codeposition–pyrolysis” method. Experimental investigations revealed that the formation of the heterojunction can tailor the valence of Co and Mo sites, which impressively modulates the electronic properties of the active sites and promotes the electrocatalytic processes. The optimal catalyst reveals a high–wave half potential (E1/2 = 0.841 V) for ORR and a low overpotential (E10 = 348 mV) for OER. The NCCM–600–based Zn–air battery displays a high peak power density of 133.36 mW cm−2 and a prolonged cycling life of more than 650 h. This work provides avenues for the development of functional materials with enhanced properties in a variety of practical energy applications.
Synergistic Effect of Zn–Co Bimetallic Selenide Composites for Lithium–Sulfur Battery
Authors: Li Deng , Pan Huinan , Lin Zhonghai , Qiu Xiulian , Zhao Xinyu , Yang Wei , Zheng Wenzhi , Ren Fengming
Published: June 2023

Compared with monometallic selenides, heterogeneous bimetallic selenides have rich phase boundaries and superior electrical conductivity. ZnSe/CoSe2 composites were prepared by introducing Zn metal and using ZIF-8/67 as the precursor through the synergistic effect between Zn and Co after selenification. The electrocatalytic conversion of polysulfide is accelerated by ZnSe through chemical adsorption and the catalytic effect. The conductive CoSe2 surface provides a rapid diffusion path for lithium ions, accelerating the conversion of the polysulfide. On the basis of their individual strengths, ZnSe and CoSe2 can jointly promote the smooth adsorptive–diffuse–catalytic conversion process of polysulfide and induce the growth of lithium sulfide around its heterogeneous interface, thus enhancing the electrochemical performance of the lithium–sulfur battery cathode materials. The ZnSe/CoSe2–S electrode, at the optimal Zn-to-Co ratio of 1:1, has a 790.06 mAh g−1 initial specific capacity at 0.2 C and excellent cycling stability at 1 C. After 300 cycles, the final capacity is 300.85 mAh g−1, and the capacity retention rate reaches 82.71%.
Privacy-Enhancing Digital Contact Tracing with Machine Learning for Pandemic Response: A Comprehensive Review
Authors: Hang Ching-Nam , Tsai Yi-Zhen , Yu Pei-Duo , Chen Jiasi , Tan Chee-Wei
Published: June 2023

The rapid global spread of the coronavirus disease (COVID-19) has severely impacted daily life worldwide. As potential solutions, various digital contact tracing (DCT) strategies have emerged to mitigate the virus’s spread while maintaining economic and social activities. The computational epidemiology problems of DCT often involve parameter optimization through learning processes, making it crucial to understand how to apply machine learning techniques for effective DCT optimization. While numerous research studies on DCT have emerged recently, most existing reviews primarily focus on DCT application design and implementation. This paper offers a comprehensive overview of privacy-preserving machine learning-based DCT in preparation for future pandemics. We propose a new taxonomy to classify existing DCT strategies into forward, backward, and proactive contact tracing. We then categorize several DCT apps developed during the COVID-19 pandemic based on their tracing strategies. Furthermore, we derive three research questions related to computational epidemiology for DCT and provide a detailed description of machine learning techniques to address these problems. We discuss the challenges of learning-based DCT and suggest potential solutions. Additionally, we include a case study demonstrating the review’s insights into the pandemic response. Finally, we summarize the study’s limitations and highlight promising future research directions in DCT.
Additive Manufacturing of Bioactive Glass and Its Polymer Composites as Bone Tissue Engineering Scaffolds: A Review
Authors: He Lizhe , Yin Jun , Gao Xiang
Published: June 2023

Bioactive glass (BG) and its polymer composites have demonstrated great potential as scaffolds for bone defect healing. Nonetheless, processing these materials into complex geometry to achieve either anatomy-fitting designs or the desired degradation behavior remains challenging. Additive manufacturing (AM) enables the fabrication of BG and BG/polymer objects with well-defined shapes and intricate porous structures. This work reviewed the recent advancements made in the AM of BG and BG/polymer composite scaffolds intended for bone tissue engineering. A literature search was performed using the Scopus database to include publications relevant to this topic. The properties of BG based on different inorganic glass formers, as well as BG/polymer composites, are first introduced. Melt extrusion, direct ink writing, powder bed fusion, and vat photopolymerization are AM technologies that are compatible with BG or BG/polymer processing and were reviewed in terms of their recent advances. The value of AM in the fabrication of BG or BG/polymer composites lies in its ability to produce scaffolds with patient-specific designs and the on-demand spatial distribution of biomaterials, both contributing to effective bone defect healing, as demonstrated by in vivo studies. Based on the relationships among structure, physiochemical properties, and biological function, AM-fabricated BG or BG/polymer composite scaffolds are valuable for achieving safer and more efficient bone defect healing in the future.
Proteomic and Global DNA Methylation Modulation in Lipid Metabolism Disorders with a Marine-Derived Bioproduct
Authors: Martínez-Iglesias Olaia , Naidoo Vinogran , Corzo Lola , Carrera Iván , Seoane Silvia , Rodríguez Susana , Alcaraz Margarita , Muñiz Adriana , Cacabelos Natalia , Cacabelos Ramón
Published: June 2023

Dyslipidemia is a significant risk factor for cardiovascular disease and stroke. Our recent findings showed that RCI-1502, a bioproduct derived from the muscle of the European S. pilchardus, has lipid-lowering effects in the liver and heart in high-fat diet (HFD) fed mice. In the present follow-up study, we investigated the therapeutic potential of RCI-1502 on gene expression and DNA methylation in HFD-fed mice and in patients with dyslipidemia. Using LC-MS/MS, we identified 75 proteins in RCI-1502 that are primarily involved in binding and catalytic activity and which regulate pathways implicated in cardiovascular diseases. In HFD-fed mice, RCI-1502 treatment significantly reduced the expression of cardiovascular disease-related genes, including vascular cell adhesion molecule and angiotensin. RCI-1502 also decreased DNA methylation levels, which were elevated in HFD-fed mice, to levels similar to those in control animals. Furthermore, peripheral blood leukocyte DNA from dyslipidemic patients exhibited higher DNA methylation levels than healthy individuals, suggesting a potential association with cardiovascular risk. Serum analysis also revealed that RCI-1502 treatment regulated cholesterol and triglyceride levels in patients with dyslipidemia. Our findings appear to suggest that RCI-1502 is an epigenetic modulator for the treatment of cardiovascular diseases, specifically in individuals with dyslipidemia.
Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview
Authors: Crafa Andrea , Cannarella Rossella , Barbagallo Federica , Leanza Claudia , Palazzolo Roberto , Flores Hunter Ausley , La Vignera Sandro , Condorelli Rosita A. , Calogero Aldo E.
Published: June 2023

Vitamin D deficiency (VDD) and erectile dysfunction (ED) heavily burden the male population. The higher prevalence of both conditions in the elderly suggests a possible relationship between the two conditions. In addition, in vitro, animal, and human studies have revealed several mechanisms that may relate VDD to ED. The main mechanism by which vitamin D might exert its action on sexual function appears to be through the regulation of endothelial function. Indeed, VDD correlates with several markers of endothelial function. The action of vitamin D on the endothelium would be exercised both indirectly through its intervention in inflammatory processes and through the production of oxygen free radicals, and directly through the regulation of vascular stiffness, the production of nitric oxide, and the regulation of vessel permeability. Furthermore, the ubiquitous distribution of the vitamin D receptor in the human body means that this hormone can also exert a beneficial effect on erectile function by interfering with those comorbidities significantly associated with ED, such as hypertension, diabetes mellitus, hypercholesterolemia, chronic kidney disease, and hypogonadism. In this review, we thoroughly and carefully presented the evidence and mechanisms that would appear to relate vitamin D levels to erectile function. Furthermore, we have summarized the meta-analytic evidence for and against this association to provide a true representation of this topic. Data published to date suggest that low levels of vitamin D could contribute to worsening erectile function through several mechanisms. Therefore, vitamin D levels should be measured in patients with ED and maintained at adequate levels by specific supplementation in case of deficiency. However, the low quality and heterogeneity of clinical trials evaluating the effects of vitamin D administration on erectile function and ED-associated comorbidities do not allow for a univocal conclusion, and indicate the need for further studies to analyze these aspects.
An Energy-Saving and Efficient Deployment Strategy for Heterogeneous Wireless Sensor Networks Based on Improved Seagull Optimization Algorithm
Authors: Cao Li , Wang Zihui , Wang Zihao , Wang Xiangkun , Yue Yinggao
Published: June 2023

The Internet of Things technology provides convenience for data acquisition in environmental monitoring and environmental protection and can also avoid invasive damage caused by traditional data acquisition methods. An adaptive cooperative optimization seagull algorithm for optimal coverage of heterogeneous sensor networks is proposed in order to address the issue of coverage blind zone and coverage redundancy in the initial random deployment of heterogeneous sensor network nodes in the sensing layer of the Internet of Things. Calculate the individual fitness value according to the total number of nodes, coverage radius, and area edge length, select the initial population, and aim at the maximum coverage rate to determine the position of the current optimal solution. After continuous updating, when the number of iterations is maximum, the global output is output. The optimal solution is the node’s mobile position. A scaling factor is introduced to dynamically adjust the relative displacement between the current seagull individual and the optimal individual, which improves the exploration and development ability of the algorithm. Finally, the optimal seagull individual position is fine-tuned by random opposite learning, leading the whole seagull to move to the correct position in the given search space, improving the ability to jump out of the local optimum, and further increasing the optimization accuracy. The experimental simulation results demonstrate that, compared with the coverage and network energy consumption of the PSO algorithm, the GWO algorithm, and the basic SOA algorithm, the coverage of the PSO-SOA algorithm proposed in this paper is 6.1%, 4.8%, and 1.2% higher than them, respectively, and the energy consumption of the network is reduced by 86.8%, 68.4%, and 52.6%, respectively. The optimal deployment method based on the adaptive cooperative optimization seagull algorithm can improve the network coverage and reduce the network cost, and effectively avoid the coverage blind zone and coverage redundancy in the network.
DNA Data Storage
Authors: Buko Tomasz , Tuczko Nella , Ishikawa Takao
Published: June 2023

The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption. Therefore, there is a need for a new, long-lasting data storage medium with high capacity, high data density, and high durability against extreme conditions. DNA is one of the most promising next-generation data carriers, with a storage density of 10¹⁹ bits of data per cubic centimeter, and its three-dimensional structure makes it about eight orders of magnitude denser than other storage media. DNA amplification during PCR or replication during cell proliferation enables the quick and inexpensive copying of vast amounts of data. In addition, DNA can possibly endure millions of years if stored in optimal conditions and dehydrated, making it useful for data storage. Numerous space experiments on microorganisms have also proven their extraordinary durability in extreme conditions, which suggests that DNA could be a durable storage medium for data. Despite some remaining challenges, such as the need to refine methods for the fast and error-free synthesis of oligonucleotides, DNA is a promising candidate for future data storage.
Effect of Re Addition on the Water–Gas Shift Activity of Ni Catalyst Supported by Mixed Oxide Materials for H2 Production
Authors: Lomonaco Jessica Gina , Sesuk Thanathon , Charojrochkul Sumittra , Tepamatr Pannipa
Published: June 2023

Water–gas shift (WGS) reaction was performed over 5% Ni/CeO2, 5% Ni/Ce-5% Sm-O, 5% Ni/Ce-5% Gd-O, 1% Re 4% Ni/Ce-5% Sm-O and 1% Re 4% Ni/Ce-5% Gd-O catalysts to reduce CO concentration and produce extra hydrogen. CeO2 and M-doped ceria (M = Sm and Gd) were prepared using a combustion method, and then nickel and rhenium were added onto the mixed oxide supports using an impregnation method. The influence of rhenium, samarium and gadolinium on the structural and redox properties of materials that have an effect on their water–gas shift activities was investigated. It was found that the addition of samarium and gadolinium into Ni/CeO2 enhances the surface area, reduces the crystallite size of CeO2, increases oxygen vacancy concentration and improves Ni dispersion on the CeO2 surface. Moreover, the addition of rhenium leads to an increase in the WGS activity of Ni/CeMO (M = Sm and Gd) catalysts. The results indicate that 1% Re 4% Ni/Ce-5% Sm-O presents the greatest WGS activity, with the maximum of 97% carbon monoxide conversion at 350 °C. An increase in the dispersion and surface area of metallic nickel in this catalyst results in the facilitation of the reactant CO adsorption. The result of X-ray absorption near-edge structure (XANES) analysis suggests that Sm and Re in 1% Re 4% Ni/Ce-5% Sm-O catalyst donate some electrons to CeO2, resulting in a decrease in the oxidation state of cerium. The occurrence of more Ce3+ at the CeO2 surface leads to higher oxygen vacancy, which alerts the redox process at the surface, thereby increasing the efficiency of the WGS reaction.
Strengthening Equitable Access to Care and Support for Children with Cerebral Palsy and Their Caregivers
Authors: Jawed Aysha , Mowry Michelle
Published: June 2023

Cerebral palsy is one of the most prevalent groups of motor disorders affecting children and adults across the world. As increasingly more children with cerebral palsy are living longer into adulthood, it is ever more crucial to ensure access to timely and needed early intervention from the onset of diagnosis, on a continuum, to optimize medical, developmental, socio-emotional, and academic outcomes for these children over time. The American Academy of Pediatrics (AAP), in collaboration with the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM), substantially revised the clinical practice guidelines for cerebral palsy in 2022, after their prior publication of the guidelines in 2006. The revised guidelines account for a range of considerations that are in line with the biopsychosocial, risk and resilience, and family-centered care models as well as promote a more strengths-based approach to care. Furthermore, there is increased emphasis in the guidelines on promoting equitable access to care as part of contributing towards health equity for all children with cerebral palsy. In addition, the 2022 guidelines clearly present recommendations for earlier diagnosis of cerebral palsy, potentially as early as infancy, as the basis for activating access to early intervention services for children that can bolster their neuroplasticity and global development from an earlier age onward. We consolidate the existing literature on caregiver perceptions, beliefs and concerns surrounding earlier diagnosis of cerebral palsy and connect them to the recommendations in the revised guidelines. We also delineate several considerations surrounding education for healthcare providers and caregivers of children in navigating the chronicity of cerebral palsy in both community and healthcare contexts. There is a scant amount of literature on cerebral palsy across traditional and nontraditional sources of media in published studies, which we also review. Lastly, we present a wealth of recommendations for further research and practice that account for the revised 2022 guidelines, caregiver preferences and acceptability of care, and health equity as the bases for strengthening equitable access to care for children with cerebral palsy on a continuum as they transition into adulthood.
Object Play and Autism Spectrum Disorders Symptoms in Toddlers Aged 12–37 Month at Risk of Developmental Disorders
Authors: Kawa Rafał
Published: June 2023

Various studies have shown a relationship between the development of language and object play in children. Children with Autism spectrum disorder (ASD) show difficulties in both of these areas of functioning. But the knowledge about the relationships between the severity of ASD symptoms and object play in children at risk of developmental disorders remains limited. To explore these relationships, 44 children aged 13–37 months took part in this study. Object play and ASD symptoms were assessed in two age groups (13–18 months and 24–37 months). The results show that ASD symptom intensity is related to object play complexity in children at risk of developmental disorders. However, these relationships are different depending on the age of the children.