bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
Authors: Peixoto Vanessa Giffoni M. N. P. , Azevedo Julianna P. , Luz Kleber G. , Almondes Katie M.
Published: April 2022

Background

Chikungunya fever is a disabling articular disease caused by chikungunya virus (CHIKV). In the past decade it has affected millions of people across America, Africa, Asia, and Europe, turning this infection into a public health concern. The acute phase of chikungunya infection is usually self-limiting, characterized by severe arthralgia, fever, chills, myalgia, headache, and rash. CHIKV neurovirulence is evident and seems to be higher among elders. Considering their susceptibility to cognitive decline and dementia, the aim of our study was to investigate whether CHIKV infection might cause long-term cognitive impairment in aged people.

Methods

A cross-sectional study was conducted with volunteers aged from 60 to 90 who had been affected by chikungunya and also with healthy controls. A structured questionnaire was used to record demographic and clinical data, functional status, and depression. Global cognitive function was assessed through MoCA. A comprehensive neuropsychological battery was performed to assess specific cognitive functions.

Results

Subjective memory complaints were present in 70% of subjects with previous chikungunya. This group had a poorer performance in MoCA (p = 0.000) and specific cognitive tests: Semantic (p = 0.05) and Phonemic Verbal Fluency (p = 0.003), 5-Digit (choice, reading, counting and alternance, p = 0.003, p = 0.014, p = 0.021, and p = 0.021, respectively), Stroop test (time, errors and interference, p = 0.000, p = 0.027 and p = 0.015, respectively), and RAVLT (word total session p = 0.05). These tests reflect performance on general executive functions, cognitive flexibility, inhibitory control, processing speed, semantic memory and episodic memory.

Conclusion

Our data suggest that CHIKV infection may cause long-term cognitive decline in aged people and might be a risk factor for future dementia in this population.
Export Expansion May Increase Adult Illness and Injury: A Quasi-Natural Experiment on China's Accession to the World Trade Organization
Authors: Chen Hongwen , Xu Junbing , Liu Jianzheng
Published: April 2022

Purpose

Exports can boost the economy, but may also cause harm to health through, for example, increased pollution and working hours. Although academic research extensively covers the impact of trade on health, few studies examine the mechanisms through which export expansion affects adult illness or injury within the past 4 weeks (illness/injury).

Method

We utilized China's entry into the World Trade Organization (WTO) as a quasi-natural experiment to investigate the relationship between export expansion and adult illness/injury. We explored the possible mechanisms and the heterogeneity of these associations. Our methodology was based on the analysis of China's Health and Nutrition Survey data, Chinese Customs databases, and China's Statistical Yearbook.

Results

Export expansion, induced by China's accession to the WTO, has a significantly positive effect on adult illness/injury [average effect (AE): 1.83%; 95% CI: 0.38–3.28%]. Our results remain robust following a series of robustness tests. Moreover, the effects of export expansion on adult illness/injury are more pronounced among urban residents (AE: 5.32%; 95% CI: 2.46–8.18%), women (AE: 2.68%; 95% CI: 0.57–4.80%), and higher-income groups (AE: 5.90%; 95% CI: 2.53–9.27%).

Conclusions

We find a statistically significant and positive effect of export expansion on adult illness/injury.
Health-Related Quality of Life and Its Related Factors in Survivors of Stroke in Rural China: A Large-Scale Cross-Sectional Study
Authors: Mei Yong-xia , Zhang Zhen-xiang , Wu Hui , Hou Jian , Liu Xiao-tian , Sang Sheng-xiang , Mao Zhen-xing , Zhang Wei-hong , Yang Dong-bin , Wang Chong-jian
Published: April 2022

Background

Stroke is a major health threat and the leading cause of mortality and disability in China. The aims of this study were to identify the possible influencing factors of health-related quality of life (HRQoL) and its domain-specific contents in stroke patients in rural areas in China.

Methods

A total of 1,709 stroke patients aged 36–79 years from the baseline data of Henan Rural Cohort study (n = 39,259) were included in the cross-sectional study. The Chinese version of the European Quality of Life Five Dimension (including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) Five Level Scale (EQ-5D-5L) and visual analog scale (VAS) were used to evaluate HRQoL in stroke patients. Tobit regression models, generalized linear models and binary logistic regression models were constructed to determine potential influencing factors of the EQ-5D utility index, as well as influencing factors of each domain and VAS score.

Results

The mean utility index and VAS scores of stroke patients were 0.885 (SD, 0.204), and 68.39 (SD, 17.31), respectively. Pain/discomfort (PD, 35.2%) and mobility (MO, 30.4%) were the most frequently reported issues. Regression models revealed that illiterate; a low monthly income; low physical activity intensity; and diabetes, anxiety, depression, or poor sleep quality were significantly associated with lower utility index and VAS scores among stroke patients. In addition, patients with stroke who were older, female, drinking, smoking, and consuming a high-fat diet, had a higher BMI, and lived with a stroke for a longer time, were also significantly associated with different dimensions of the EQ-5D.

Conclusion

Patients with stroke in rural areas in China had a low HRQoL. Factors associated with the EQ-5D utility index as well as each domain and VAS score, need to be considered by health providers in rural areas. Patients with stroke in rural areas need to be included in national basic public medical services and managed systematically by medical institutions.
Price Policy and Taxation as Effective Strategies for Tobacco Control
Authors: Felsinger Richard , Groman Ernest
Published: April 2022

Objective

Only 13% of the world's population are living in countries imposing appropriate tobacco tax-rates. This study aims to promote the implementation of price policy measures as a striking tobacco control strategy in Austria and to encourage other countries to further increase their taxes to WHO best-practice levels.

Method

This study used the yearly economic data from Austria from 1997 to 2015. Applying a model for regression analysis, the price elasticity of total tobacco consumption was estimated.

Results

Between 1997 and 2015 the price elasticity of demand for tobacco products (including cigarettes, cigars, and other tobaccos) was −0.661, however, the result is statistically insignificant. When excluding 2 anomalous years and removing a variable of the regression model the elasticity was −0.691 and statistically significant, indicating that a 1% increase in tobacco prices will result in a 0.691% decrease of tobacco consumption.

Conclusion

The responsiveness of Austrian smokers to price changes has increased during the last decades. Because other activities showed no significance in the analysis, this study should encourage countries world-wide to use price policy and taxation more intensively in order to reduce smoking rates effectively.
The COVID-19 Pandemic Related Lived Experiences of Individuals With a Spinal Cord Injury/Disease
Authors: Simpson Ethan , Miller William C. , Schmidt Julia , Borisoff Jaimie , Mortenson W. Ben
Published: April 2022

Introduction

COVID-19 related restrictions and recommendations have impacted everyone. Those living with a disability, such as individuals with a spinal cord injury (SCI), may have had pandemic related changes made yet more challenging by societal failures to accommodate their mobility, physical abilities, and health care needs. To better understand participants experiences we drew upon Heidegger's phenomenology and the mobilities paradigm. The objective of this study was to explore COVID-19 pandemic related lived-experiences of individuals with an SCI.

Materials and Methods

This study used an interpretive phenomenological methodology. Semi-structured interviews were the primary means of data collection. These were conducting in May and June of 2020, roughly 2–3 months into the pandemic. Transcript data were analyzed using a phenomenological methodology.

Results

We interviewed 22 participants with SCI, the mean age was 54 years, and nine were females. We identified three themes: (1) Experiencing changes to mobility and daily life described how new rules had impacted everyday life and usual routines, particularly in regard to mobility. (2) Struggling with new challenges explored some of the negative experiences of the pandemic. (3) Being resilient in the face of a new normal conveyed the resilience participants exhibited despite challenges.

Conclusion

Although our findings indicate some positive changes and highlight the strengths that many individuals with SCI have, they also accentuate issues with ableism within the medical system. Certain changes were made primarily because people without disabilities needed them, and several COVID-19 changes were made without consulting individuals with disabilities. With physical movement restricted, our findings emphasize the importance of the movement of information and a need for increased dialogue with people in the SCI community about their ongoing pandemic related needs.
Adaptive Centipede Walking via Synergetic Coupling Between Decentralized Control and Flexible Body Dynamics
Authors: Yasui Kotaro , Takano Shunsuke , Kano Takeshi , Ishiguro Akio
Published: April 2022

Multi-legged animals such as myriapods can locomote on unstructured rough terrain using their flexible bodies and legs. This highly adaptive locomotion emerges through the dynamic interactions between an animal’s nervous system, its flexible body, and the environment. Previous studies have primarily focused on either adaptive leg control or the passive compliance of the body parts and have shown how each enhanced adaptability to complex terrains in multi-legged locomotion. However, the essential mechanism considering both the adaptive locomotor circuits and bodily flexibility remains unclear. In this study, we focused on centipedes and aimed to understand the well-balanced coupling between the two abovementioned mechanisms for rough terrain walking by building a neuromechanical model based on behavioral findings. In the behavioral experiment, we observed a centipede walking when part of the terrain was temporarily removed and thereafter restored. We found that the ground contact sense of each leg was essential for generating rhythmic leg motions and also for establishing adaptive footfall patterns between adjacent legs. Based on this finding, we proposed decentralized control mechanisms using ground contact sense and implemented them into a physical centipede model with flexible bodies and legs. In the simulations, our model self-organized the typical gait on flat terrain and adaptive walking during gap crossing, which were similar to centipedes. Furthermore, we demonstrated that the locomotor performance deteriorated on rough terrain when adaptive leg control was removed or when the body was rigid, which indicates that both the adaptive leg control and the flexible body are essential for adaptive locomotion. Thus, our model is expected to capture the possible essential mechanisms underlying adaptive centipede walking and pave the way for designing multi-legged robots with high adaptability to irregular terrain.
Solar Energy Modeling and Mapping for the Sustainable Campus at Monash University
Authors: Radosevic Nenad , Liu Gang-Jun , Tapper Nigel , Zhu Xuan , Sun Qian (Chayn)
Published: April 2022

An increase in energy demands and positive public acceptance of clean energy resources have contributed to a growing need for using solar energy in cities. Solar photovoltaic (PV) deployment relies on suitable locations with high solar energy potential. In the urban context, building rooftops are often considered one of the most available locations for solar PV installation. This work demonstrates a new geospatial-method for spatiotemporal modeling and mapping solar energy potential based on a high-resolution (0.2 m) digital surface model (DSM) and solar radiation dataset. The proposed method identifies building rooftops with a high solar energy potential by using the Solar Analyst (SA) model. The results show that 93.5% of the rooftop area has high solar energy potential in the study area. The annual averaged sum of solar irradiation values is estimated to be 1.36 MWh/m2. In addition, the study showed that sloped rooftops facing to the north received up to 30% more incoming solar radiation than other rooftops with different geometry and orientation. The results are validated using recorded energy output data from four existing solar PV systems in the study area. The return on the initial investment of PV systems installation is estimated to be from four to five years.
RETRACTED: Safety Evaluation of Antituberculosis Drugs During Pregnancy: A Systematic Review and Meta-Analysis
Authors: Zhou Xiaomei , Fang Guoying , Xie Yaqing , Wei Anqi , Huang Feixiang
Published: April 2022

Background

Pregnant women are a common group of people with tuberculosis,especially in patients infected with HIV at the same time. Antituberculosis drug prophylaxis is effective in reducing tuberculosis infection in pregnant women and fetuses after pregnancy, but its safety is still worthy of in-depth discussion. In this study, we conducted a systematic review and meta-analysis of reports on the use of antituberculosis drugs during pregnancy in recent years to provide evidence for clinical diagnosis and treatment.

Methods

The PubMed, Embase, Web of Science databases, Ovid, and clinicaltrials.gov were searched. Search for clinical randomized controlled studies and cohort studies on the use of antituberculosis drugs during pregnancy published in the databases from January 2000 to September 2021 was performed using the Stata 16.0 software after screening qualified bodies of literature.

Results

On the basis of the initial search of 408 articles, this study included a total of 8 articles and 2,563 patients after screening; meta-analysis results showed that preventive treatment with antituberculosis drugs did not increase the incidence of serious maternal adverse events [RR = 0.99, 95% CI (.88, 1.12), Z = −0.108, P = 0.914], did not increase drug hepatotoxicity [RR = 1.13, 95% CI (.9, 1.43), Z = 1.071, P = 0.284], did not increase the incidence of peripheral nerve disease [RR = 1.52, 95% CI (.85, 2.71), Z = 1.412, P = 0.158], did not increase maternal mortality [RR = 0.67, 95% CI (.27, 1.7), Z = −0.84, P = 0.401], and could significantly reduce adverse pregnancy outcomes [RR = 0.78, 95% CI (0.68, 0.89), Z = −3.581, P < 0.0001].

Discussion

The use of antituberculosis drugs for preventive treatment during pregnancy is safe and can obtain better pregnancy outcomes.
Case Report: Bordetella bronchiseptica Meningoencephalomyelitis in a Dog
Authors: Rylander Helena , Djani Dylan M. , Cameron Starr
Published: April 2022

A 15-month-old male neutered Wirehaired Pointer mixed-breed dog presented with fever and cervical pain. Cerebrospinal fluid (CSF) analysis showed neutrophilic pleocytosis with intracellular bacteria, and culture of CSF grew Bordetella bronchiseptica. The patient became non-ambulatory 3 days after CSF collection. He was treated with low-dose prednisone for 3.5 months and doxycycline for 1 year. Recheck CSF analysis 1 month after diagnosis showed reduction of inflammation and 3 months after diagnosis revealed only increased protein. The patient improved neurologically over several months and was weakly ambulatory 5 months and fully ambulatory 7 months after diagnosis. Whole genome sequencing of the bacterial isolate and a live modified intranasal vaccine similar to the one the dog had been vaccinated with 7 weeks before diagnosis was similar but not an exact match. Bacterial meningitis should be considered, and culture of CSF is recommended, in cases of neutrophilic pleocytosis of CSF.
Co-Detection of VEGF-A and Its Regulator, microRNA-181a, May Indicate Central Nervous System Involvement in Pediatric Leukemia
Authors: Egyed Bálint , Horváth Anna , Semsei Ágnes F. , Szalai Csaba , Müller Judit , Erdélyi Dániel J. , Kovács Gábor T.
Published: April 2022

Central nervous system (CNS) involvement is a leading cause of therapy-refractory pediatric acute lymphoblastic leukemia (pALL), which is aggravated by underdiagnosing CNS disease with the currently used cell-based approach of cerebrospinal fluid (CSF) diagnostics. Our study focused on developing novel subcellular CNS leukemia indicators in the CSF and the bone marrow (BM) of patients with pALL. Serial liquid biopsy samples (n = 65) were analyzed by Elisas to measure the level of essential proteins associated with blast cell CNS trafficking, vascular endothelial growth factor A (VEGF-A) and integrin alpha 6 (ITGA6). In CSF samples from early induction chemotherapy, VEGF-A concentration were uniformly elevated in the CNS-positive group compared to those patients without unambiguous meningeal infiltration (9 vs Nine patients, Δc = 17.2 pg/ml, p = 0.016). Expression of miR-181a, a VEGFA-regulating microRNA which showed increased level in CNS leukemia in our previous experiments, was then paralleled with VEGF-A concentration. A slight correlation between the levels of miR-181a and VEGF-A indicators in CSF and BM samples was revealed (n = 46, Pearson’s r = 0.36, p = 0.015). After validating in international cohorts, the joint quantification of miR-181a and VEGF-A might provide a novel tool to precisely diagnose CNS involvement and adjust CNS-directed therapy in pALL.
Comparison of medial tibial stress syndrome and its severity in regular runners vs treadmill runners
Authors: Shafiq Faiza , Sultan Tayyaba , Nadeem Khushboo , Khalid Amna , Mazhar Bisma
Published: April 2022

Medial Tibial Stress Syndrome (MTSS) usually known as shin splints is an exercise related overuse injury of lower extremity. It mostly affects athletes and military recruits. The incidence of MTSS is 16-44% in a variety of sports, such as field events and long-distance running. Contributing factors for MTSS are female gender, increased BMI, increased navicular drop, poor running kinematics and previous history of MTSS. Most common symptom in MTTS is pain across the posteromedial border of the tibia which is increased by activity and relieved through rest. It can be reliably diagnosed with a history and clinical examination. MRI and CT scan are used to rule out other conditions which have similar symptoms. The severity of condition is determined through MTSS score. Management of MTSS includes rest, icing, massage, acupuncture, leg braces and modalities; whereas surgery is reserved for refractory cases.
Association of body mass index with fitness index among male and female physical therapy students in Lahore
Authors: Mahmood Tahir , Maqsood Umer , Raza Shah Zaib , Zaka Hashim , Aziz Asad , Saleem Nadia
Published: April 2022

Background: Body Mass Index is an important predictor of physical fitness that needs to be addressed in job-related work in physical therapy profession. Objectives: To determine the association of BMI with fitness Index among physical therapy students. Methods: This was a cross-sectional associational study. The Sample of 156 undergraduate students between the ages of 20 to 30 years was included. By using a convenient sampling technique, data was collected from Azra Naheed Medical College and the Institute of Child Health and Children Hospital Lahore after ethical approval on 30th January 2018 from Azra Naheed Medical College. Harvard Step Index was used for measuring Fitness Index and Body Mass Index was measured using height and weight. SPSS 22 version was used for the analysis of outcomes of interest. Results: In our study 85 (54.4%) females and 71 (45.51%) males students with mean age of 25.4+4.6 participated. In male physiotherapy students, 11 (17.18%) out of 64 were excellent in physical fitness, 12 (18.75%) were good, 4 (6.25%) were average, 4 (6.25%) were low average and 54 (57.44%) were poor. While in female physiotherapy students only 6 (6.59%) out of 91 were excellent, 18 (19.78%) were good, 5 (5.49%) above average, 2 (2.19%) were low average and 40 (43.95%) were poor. Regarding BMI and Fitness Index, 47 (30.12%) had poor, while 28 (17.94%) had good and 14 (8.94%) had excellent fitness level. Conclusion: The study concluded that Physical therapy students were not having good fitness level. The male students were found fit compared to females, but they were also not to optimum required level of fitness. P value calculated through chi square test was 0.00 showed BMI and physical fitness was associated to each other.
Analysis of Management, Labor and Economics of Milking Systems in Intensive Goat Farms
Authors: da Borso Francesco , Kic Pavel , Kante Jasmina
Published: April 2022

Dairy goat farms are growing in the world, but their technological level and, particularly, milking equipment are less developed than those of dairy cow farms. This study aims to evaluate milking parlors in the current situation in modern goat farms and suggest possible solutions or improvements. Ten goat farms located in various municipalities of the Friuli-Venezia Giulia region (Northeast Italy) adopting different milking systems (parallel milking parlors, milking carts, and milking buckets) were monitored. The mathematical model developed originally for the evaluation of milking parlors for dairy cows was modified and adapted to goat milking systems. Time for milking and final specific direct costs are the main parameters that enable evaluation and choice of suitable milking parlor; neglect or promotion of only one of the mentioned criteria may lead to an uneconomic investment or impaired operation of a farm. The research results showed that the modern milking systems, with a greater number of stalls and milking clusters, have a greater capacity and require less time for milking a goat than bucket and cart systems. The study also demonstrated that increasing the capacity of dairy goat farms enables a reduction of the final specific costs for milking.
New Alternative to Control Stenoma impressella (Lepidoptera: Elachistidae) Using Bacillus thuringiensis Commercial Formulations in Oil Palm Crops
Authors: Montes-Bazurto Luis Guillermo , Bustillo-Pardey Alex Enrique , Morales Anuar
Published: April 2022

Using chemical insecticides in IPM is possible and could be sustainable. To find a sustainable alternative to control S. impressella, we assessed the biological activities of five commercial formulations of Bacillus thuringiensis. First, these formulations were evaluated under laboratory conditions. No differences were observed between the commercial formulations Bt_A_1, BT_K_2, and Bt_K_3. Then, the three formulations were compared in further experiments. This bioassay was performed under field conditions in palms naturally infested by S. impressella, and differences in larval mortality rates were observed between commercial formulations. The mortality rates caused by Bt_A_1 and BT_K_3 did not significantly differ. The third step evaluated different doses of Bt_A_1 and BT_K_3 formulations (250, 500, 750, and 1000 g/Ha) under field conditions. Seven days after spraying, differences were only observed between Bt_A_1 and BT_K_3 and the control. Finally, these two formulations were evaluated under field conditions. The mortality rates caused by Bt_A_1 and BT_K_3 were 77.2% and 85.3%, respectively. These findings show that commercial formulations of B. thuringiensis subsp. aizawai (Bt_A_1) and B. thuringiensis var. aizawai (BT_K_3) exhibit high biological activities against S. impressella larvae and can be included in the integrated management of S. impressella.
Effects of Fermented Manure Bedding Thickness on Bulls’ Growth, Behavior, and Welfare as Well as Barn Gases Concentration in the Barn
Authors: Niu Kaifeng , Zhang Xinxin , Chen Chao , Yang Liguo
Published: April 2022

Providing clean, comfortable bedding is essential for the growth and welfare of bulls. This study was aimed to investigate the effects of bedding thickness on growth performance, behavior, and welfare of bulls as well as gases concentration in the barn. Thirty-six healthy Simmental bulls (7–9 months old) were randomly divided into three groups and raised on 0 cm (concrete floor, CF), 15 cm (shallow fermented bedding, SFB), and 30 cm (deep fermented bedding, DFB) fermented manure bedding. The results showed that the DFB group exhibited the optimal ADG (average daily gain), F/G (ratio of feed to gain), hoof health, body hygiene, and lying time, followed by the SFB group and the CF group (p < 0.05). As for the barn gas environment, the contents of ammonia and carbon dioxide were the lowest in the DFB group, followed by the SFB group, and they were the highest in the CF group at the same time points (p < 0.01). In summary, fermented manure bedding significantly improves the growth performances, behavior, and welfare of bulls as well as gases concentration, and the improvement effect achieved by deep fermented bedding is more obvious than by shallow fermented bedding.
Effect of TMR Briquettes on Milk Production, Nutrient Digestibility, and Manure Excretions of Dairy Cows in the Dry Zone of Sri Lanka
Authors: Karunanayaka Wishma , Nayananjalie Deepthi , Appuhamy Ranga , Adikari Jayantha , Weerasingha Viraj , Kumari Amali , Somasiri Sharini , Liyanage Ridma , Mangalika Priyani , Sundarabarathy Thenmoli
Published: April 2022

We showed previously that TMR briquettes made with a variety of forages and industrial by-products had higher crude protein and energy concentrations than the conventional diet including fresh-cut Guinea grass and commercial cattle pellet (CTL). The study objective was to determine to what extent the nutritional advantages of TMR briquettes would be translated into the milk production of dairy cows in the dry zone of Sri Lanka. Nine Jersey × Sahiwal cows were assigned to CTL or two TMR briquettes in a 3 × 3 Latin square design with three periods each including 14 d for production measurement and 7 d for total faeces and urine collection. The TMR briquettes tended to increase milk yield (5.55 to 6.59 kg/d, p = 0.092), milk protein yield (0.170 vs. 0.203 kg/d, p = 0.091) and DMI (6.50 to 7.16 kg/d, p = 0.070), and decreased milk urea nitrogen (13.0 to 10.5 mg/dL, p < 0.006). The TMR briquettes had a higher organic matter and neutral detergent fibre digestibility (p < 0.001), and lower urinary N excretions as a % of N intake (p = 0.149). In conclusion, the TMR briquettes can improve forage digestibility, milk production and environmental sustainability of dairy cows in the dry zone of Sri Lanka.
Gelidiales Are Not Just Agar—Revealing the Antimicrobial Potential of Gelidium corneum for Skin Disorders
Authors: Matias Margarida , Pinteus Susete , Martins Alice , Silva Joana , Alves Celso , Mouga Teresa , Gaspar Helena , Pedrosa Rui
Published: April 2022

In recent decades, seaweeds have proven to be an excellent source of bioactive molecules. Presently, the seaweed Gelidium corneum is harvested in a small area of the Portuguese coast exclusively for agar extraction. The aim of this work was to fully disclosure Gelidium corneum as a sustainable source of antimicrobial ingredients for new dermatological formulations, highlighting its potential to be explored in a circular economy context. For this purpose, after a green sequential extraction, these seaweed fractions (F1–F5) were chemically characterized (1H NMR) and evaluated for their antimicrobial potential against Staphylococcus aureus, Staphylococcus epidermidis and Cutibacterium acnes. The most active fractions were also evaluated for their effects on membrane potential, membrane integrity and DNA damage. Fractions F2 and F3 displayed the best results, with IC50 values of 16.1 (7.27–23.02) μg/mL and 51.04 (43.36–59.74) μg/mL against C. acnes, respectively, and 53.29 (48.75–57.91) μg/mL and 102.80 (87.15–122.30) μg/mL against S. epidermidis, respectively. The antimicrobial effects of both fractions seem to be related to membrane hyperpolarization and DNA damage. This dual mechanism of action may provide therapeutic advantages for the treatment of skin dysbiosis-related diseases.
Systemic Antibiotic Prophylaxis in Maxillofacial Trauma: A Scoping Review and Critical Appraisal
Authors: Goormans Femke , Coropciuc Ruxandra , Vercruysse Maximilien , Spriet Isabel , Willaert Robin , Politis Constantinus
Published: April 2022

Infection after maxillofacial trauma remains an important complication, with a significant socio-economic impact. While consensus exists that systemic antibiotic prophylaxis reduces the risk of infection in the management of maxillofacial fractures, the type, and duration remain controversial. Therefore, the purpose of this scoping review was to provide an overview of the current evidence that supports the use of prophylactic antibiotics in the treatment of maxillofacial fractures. A comprehensive literature search on 1 January 2022, in PubMed, Web of Science, Embase, and Cochrane, revealed 16 articles. Most studies focused on the duration of systemic antibiotic prophylaxis and compared a one-day to a five-day regimen. Included studies showed considerable variability in design and research aims, which rendered them difficult to compare. Furthermore, a variety of antibiotic regimens were used, and most studies had a short follow-up period and unclear outcome parameters. This scoping review demonstrates the lack of well-constructed studies investigating the type and duration of systemic antibiotic prophylaxis in the treatment of maxillofacial trauma. Based on the included articles, prolonging antibiotic prophylaxis over 24 h for surgically treated fractures does not appear to be beneficial. Furthermore, there is no evidence for its use in conservatively treated fractures. These results should be interpreted with caution since all included studies had limitations.
Antibiotic Therapy for Prosthetic Joint Infections: An Overview
Authors: Le Vavasseur Benjamin , Zeller Valérie
Published: April 2022

Prosthetic joint infection (PJI) is a severe complication after arthroplasty. Its management combines surgical intervention, whose type depends on the clinical situation, and prolonged high-dose antibiotics adapted to the responsible microorganism(s) and the patient. Antibiotics are only one part of the therapeutic regimen and are closely related to the surgical strategy. Their efficacy depends to a large extent on the choice and quality of the surgical procedure, and the quality of the microbiological diagnosis. Although guidelines have been published, many aspects of antibiotic therapy remain poorly established. Choosing the optimal agent(s) is one aspect, with others being optimization of drugs’ pharmacokinetic/pharmacodynamic parameters, the choice of administration route, use of monotherapy or combination regimens, therapeutic drug-monitoring and patient education to improve compliance and tolerance. Herein, we address PJI management based on recent literature data, guidelines and the experience of our referral center for complex bone-and-joint infections.
Bovine Respiratory Disease: Conventional to Culture-Independent Approaches to Studying Antimicrobial Resistance in North America
Authors: Andrés-Lasheras Sara , Jelinski Murray , Zaheer Rahat , McAllister Tim A.
Published: April 2022

Numerous antimicrobial resistance (AMR) surveillance studies have been conducted in North American feedlot cattle to investigate the major bacterial pathogens of the bovine respiratory disease (BRD) complex, specifically: Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. While most bacterial isolates recovered from healthy cattle are susceptible to a repertoire of antimicrobials, multidrug resistance is common in isolates recovered from cattle suffering from BRD. Integrative and conjugative elements (ICE) have gained increasing notoriety in BRD-Pasteurellaceae as they appear to play a key role in the concentration and dissemination of antimicrobial resistant genes. Likewise, low macrolide susceptibility has been described in feedlot isolates of M. bovis. Horizontal gene transfer has also been implicated in the spread of AMR within mycoplasmas, and in-vitro experiments have shown that exposure to antimicrobials can generate high levels of resistance in mycoplasmas via a single conjugative event. Consequently, antimicrobial use (AMU) could be accelerating AMR horizontal transfer within all members of the bacterial BRD complex. While metagenomics has been applied to the study of AMR in the microbiota of the respiratory tract, the potential role of the respiratory tract microbiome as an AMR reservoir remains uncertain. Current and prospective molecular tools to survey and characterize AMR need to be adapted as point-of-care technologies to enhance prudent AMU in the beef industry.
Phytochemical Profile and Antioxidant Activity of Lavandula angustifolia and Lavandula x intermedia Cultivars Extracted with Different Methods
Authors: Dobros Natalia , Zawada Katarzyna , Paradowska Katarzyna
Published: April 2022

Lavender is a valuable perennial plant from the Lamiaceae family. It is grown mainly for its essential oil, but it also contains polar bioactive compounds such as polyphenols and coumarins. Their level depends on the species, cultivars, geographical origin, climatic conditions, harvest time and extraction method. The authors investigated the effect of several extraction procedures (maceration, decoction and ultrasound-assisted extraction) applied to three cultivars of Lavandula angustifolia (Betty’s Blue, Elizabeth, Hidcote) and two cultivars of Lavandula x intermedia (Grosso, Gros Bleu) on the yield of the polyphenolic compounds and antioxidant activity. HPLC analysis showed the presence of rosmarinic acid (2.52–10.82 mg/g), ferulic acid glucoside (2.94–8.67 mg/g), caffeic acid (1.70–3.10 mg/g), morin (1.02–13.63 mg/g), coumarin (1.01–5.97 mg/g) and herniarin (1.05–8.02 mg/g). The content of phenolic acids and flavonoids was higher in lavender, while the content of coumarins was higher in lavandin in all types of extracts. The antioxidant activity was determined by DPPH-EPR assay for antiradical properties (104.58–206.77 μmol Trolox/g) and FRAP assay for reducing properties (79.21–203.06 μmol Trolox/g). The obtained results showed that the cultivar is the dominant factor differentiating the samples. Still, the extraction method plays an important role in the final bioactive substances content and antioxidant properties of obtained extracts.
The Protective Effect of Sericin on AML12 Cells Exposed to Oxidative Stress Damage in a High-Glucose Environment
Authors: Jing Feng-Ya , Weng Yu-Jie , Zhang Yu-Qing
Published: April 2022

Two types of sericin peptides with high molecular weight (HS) and low molecular weight (LS) were obtained by the green water boiling ultrasonic method and the Ca(OH)2 ultrasonic method, respectively. In this experiment, a high-glucose medium was used to simulate a high-glucose environment in the body, and appropriate concentrations of normal alpha mouse liver 12 (AML12) hepatocytes were exposed to a series of concentrations of HS and LS. The effects of the two sericin peptides on AML12 cells in a high-glucose environment were investigated in detail in terms of oxidative stress and inflammatory factor expression in cells. HS and LS-groups reduced the levels of oxidative stress, inflammation, and tumor necrosis factor (TNF), and the latter significantly reduced the levels of TNF-α, interleukin (IL)-6, and nuclear factor (NF)-κB in AML12 cells. Additionally, it significantly reduced the oxidative stress damage caused by the high-glucose environment compared with normal AML12 cells. These results indicate that sericin may be an antioxidant recovered from industrial waste, and has potential and for use in the reduction of environmental pollution and the development of functional foods with antioxidation and antihyperglycemic effect.
Water Hardness Can Reduce the Accumulation and Oxidative Stress of Zinc in Goldfish, Carassius auratus
Authors: Choi Cheol Young , Li Zhongze , Song Jin Ah , Park Young-Su
Published: April 2022

We investigated the changes in toxicity stress in goldfish, Carassius auratus, under exposure to different concentrations of Zn and water hardness for 14 days. We analyzed the changes in water hardness and Zn accumulation after exposure. To investigate the stress levels, the expression of metallothionein, caspase-3 activity, NO activity, and total antioxidant capacity were detected. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were also performed to measure apoptosis in the liver. The results showed that compared to the control group, a more significant difference in the accumulation of Zn in body stress markers (metallothionein, caspase-3 activity, NO activity, and total antioxidant capacity) were observed with increasing Zn concentration and exposure time. Notably, at the same Zn concentration and exposure time, lower stress levels were discovered in the samples under harder water conditions. Finally, the TUNEL assay showed that Zn accumulation caused apoptosis and high water hardness could reduce the apoptosis. In conclusion, we found that high water hardness can influence the absorption of Zn, and alleviating the hardness levels can reduce the toxicity stress caused by Zn.
Serious Games and Mixed Reality Applications for Healthcare
Authors: Condino Sara , Gesi Marco , Viglialoro Rosanna Maria , Carbone Marina , Turini Giuseppe
Published: April 2022

Serious games are games in which the main goal is not entertainment, but a serious purpose ranging from the acquisition of knowledge to interactive training, to name just a few [...]
Shallow Water Waves and Conservation Laws with Dispersion Triplet
Authors: Biswas Anjan , Coleman Nyah , Kara Abdul H. , Khan Salam , Moraru Luminita , Moldovanu Simona , Iticescu Catalina , Yıldırım Yakup
Published: April 2022

This paper secures solitary waves and conservation laws to the familiar Korteweg–de Vries equation and Gardner’s equation with three dispersion sources. The traveling wave hypothesis leads to the emergence of such waves. The three sources of dispersion are spatial dispersion, spatio–temporal dispersion and the dual-emporal–spatial dispersion. The conservation laws are enumerated for these models, evolved from the multiplier approach. The conserved quantities are computed with the solitary wave solutions that were recovered.
A 19 ps Precision and 170 M Samples/s Time-to-Digital Converter Implemented in FPGA with Online Calibration
Authors: Zhang Mengdi , Zhao Ye , Han Zhengsheng , Zhao Fazhan
Published: April 2022

This paper presents a 19 ps precision and 170 M samples/s time-to-digital converter (TDC) in FPGA. Through the direct count method and tapped delay line method, the coarse count and fine count can be extracted, respectively. The direct count is realized by the 350 M clock and the tapped delay line is constructed by the CARRY4 block. The ones-counter encoder is used to convert the thermometer code with bubble errors into binary code, which is applicable to all the FPGA chips. This work not only explains the schematic of the ones-counter encoder, but also shows how to configure it. Owing to the inconsistency of delay elements caused by process, bin-by-bin calibration is utilized to improve the differential nonlinearities (DNL) and integral nonlinearities (INL) of the TDC. A novel method was developed to compensate the influence of voltage and temperature. As the delay elements vary with voltage and temperature, a frequency counter is used to extrapolate and compensate its effect on the delay line. All of the above strategies use online calibration and improve the precision and sampling rate of TDC. The experimental results show the least significant bit (LSB) achieves 17.4 ps, the DNL is within [−0.90, 1.67] LSB, and the INL is in the range of [−1.90, 3.31] LSB.
A Place to Be? Use of Winter Gardens with and without Automatic Enrichment Devices by Laying Hens
Authors: Riedel Anna , Rieke Lorena , Kemper Nicole , Spindler Birgit
Published: April 2022

Since the abolition of beak trimming in laying hens in Germany, the importance of adequate enrichment material to help reduce feather pecking and cannibalism has grown. Here we tested an automatic enrichment device dosing grain via rough-coated pecking plates (PPs) on an organic farm, comparing its offer in four winter gardens (WGs). Winter garden (WG) 1 served as the control area without an automatic enrichment device, while WGs 2–4 offered different quantities of PPs, with WG 2 offering double the amount of PPs as WGs 3 and 4. The number of laying hens (Lohmann Brown Lite) per m² and close to the enrichment device (one hen‘s body length around) was determined using photo records. The usage behavior of the hens differed in the four WGs and with the animals’ age. Over the whole husbandry period (60 weeks), on average, 1.48 hens/m² were detected in the control area (WG 1), and a mean of 2.27 hens/m² in the enriched WGs. Compared to WG 1, the number of hens per m² was higher in WG 2 (2.43 hens/m²) and WG 3 (2.59 hens/m²) (p < 0.05), but similar in WG 4 (1.79 hens/m²). At the end of the husbandry period, fewer animals (mean of all WGs: 1.43 hens/m²) used the WGs than from beginning to the middle of the laying period (mean of all WGs: 2.05–2.15 hens/m²; p < 0.05). Our data indicate that the automatic enrichment device positively influences the animals’ use of the WG.
Mapping Server Collaboration Architecture Design with OpenVSLAM for Mobile Devices
Authors: Song Jooeun , Kook Joongjin
Published: April 2022

SLAM technology, which is used for spatial recognition in autonomous driving and robotics, has recently emerged as an important technology to provide high-quality AR contents on mobile devices due to the spread of XR and metaverse technologies. In this paper, we designed, implemented, and verified the SLAM system that can be used on mobile devices. Mobile SLAM is composed of a stand-alone type that directly performs SLAM operation on a mobile device and a mapping server type that additionally configures a mapping server based on FastAPI to perform SLAM operation on the server and transmits data for map visualization to a mobile device. The mobile SLAM system proposed in this paper mixes the two types in order to make SLAM operation and map generation more efficient. The stand-alone type of SLAM system was configured as an Android app by porting the OpenVSLAM library to the Unity engine, and the map generation and performance were evaluated on desktop PCs and mobile devices. The mobile SLAM system in this paper is an open-source project, so it is expected to help develop AR contents based on SLAM in a mobile environment.
Preliminary Evaluation of Derived Concentration Guideline Level for Surface Soil at Wolsong NPP Site Using RESRAD-ONSITE Code
Authors: Kwon Chung-Gi , Ahn Seokyoung , Lee Jun-Yeop
Published: April 2022

A preliminary derived concentration guideline level (DCGL) was calculated for the soil of the Wolsong nuclear power plant (NPP) (the first commercial pressurized heavy water reactor in South Korea) site using the RESRAD-ONSITE computational code. In total, fourteen selected radionuclides were analyzed after considering the preliminary evaluation information of radionuclides observed in the pressure tube specimen in the Wolsong Unit 1 heavy water reactor and previous NPP decommissioning cases. Furthermore, a geological structure model of the Wolsong NPP site was established according to the safety analysis report of the Wolsong NPP. In addition, the distribution coefficients (Kd) of various radionuclides were derived using the JAEA-SDB and the pH information of the groundwater around the Wolsong NPP site. The DCGL for surface soil of the Wolsong NPP site was derived via the application of criteria for the site release to facilitate unrestricted reuse. Moreover, preliminary dose evaluation and relevant analysis were performed according to the Wolsong NPP site resident scenario. The novelty of this study lies in the first calculation of the preliminary DCGL values for the case of the pressurized heavy water reactor (Wolsong NPP) site. It is expected that further reliable DCGL results might be achievable if more precise radionuclide information and site-specific parameters with respect to the Wolsong NPP site are secured and applied in the future.
Special Issue on “Computational Modeling and Simulation of Solids and Structures: Recent Advances and Practical Applications”
Authors: Kim Jin-Gyun , Lim Jae Hyuk , Persson Peter
Published: April 2022

Computational modeling and simulation are essential to solid and structural mechanics [...]
Microemulsions and Nanoemulsions in Skin Drug Delivery
Authors: Souto Eliana B. , Cano Amanda , Martins-Gomes Carlos , Coutinho Tiago E. , Zielińska Aleksandra , Silva Amélia M.
Published: April 2022

Microemulsions and nanoemulsions are lipid-based pharmaceutical systems with a high potential to increase the permeation of drugs through the skin. Although being isotropic dispersions of two nonmiscible liquids (oil and water), significant differences are encountered between microemulsions and nanoemulsions. Microemulsions are thermodynamically stable o/w emulsions of mean droplet size approximately 100–400 nm, whereas nanoemulsions are thermodynamically unstable o/w emulsions of mean droplet size approximately 1 to 100 nm. Their inner oil phase allows the solubilization of lipophilic drugs, achieving high encapsulation rates, which are instrumental for drug delivery. In this review, the importance of these systems, the key differences regarding their composition and production processes are discussed. While most of the micro/nanoemulsions on the market are held by the cosmetic industry to enhance the activity of drugs used in skincare products, the development of novel pharmaceutical formulations designed for the topical, dermal and transdermal administration of therapeutic drugs is being considered. The delivery of poorly water-soluble molecules through the skin has shown some advantages over the oral route, since drugs escape from first-pass metabolism; particularly for the treatment of cutaneous diseases, topical delivery should be the preferential route in order to reduce the number of drugs used and potential side-effects, while directing the drugs to the site of action. Thus, nanoemulsions and microemulsions represent versatile options for the delivery of drugs through lipophilic barriers, and many synthetic and natural compounds have been formulated using these delivery systems, aiming to improve stability, delivery and bioactivity. Detailed information is provided concerning the most relevant recent scientific publications reporting the potential of these delivery systems to increase the skin permeability of drugs with anti-inflammatory, sun-protection, anticarcinogenic and/or wound-healing activities. The main marketed skincare products using emulsion-based systems are also presented and discussed.
Densification: Hyaluronan Aggregation in Different Human Organs
Authors: Stecco Antonio , Cowman Mary , Pirri Nina , Raghavan Preeti , Pirri Carmelo
Published: April 2022

Hyaluronan (HA) has complex biological roles that have catalyzed clinical interest in several fields of medicine. In this narrative review, we provide an overview of HA aggregation, also called densification, in human organs. The literature suggests that HA aggregation can occur in the liver, eye, lung, kidney, blood vessel, muscle, fascia, skin, pancreatic cancer and malignant melanoma. In all these organs, aggregation of HA leads to an increase in extracellular matrix viscosity, causing stiffness and organ dysfunction. Fibrosis, in some of these organs, may also occur as a direct consequence of densification in the long term. Specific imaging evaluation, such dynamic ultrasonography, elasto-sonography, elasto-MRI and T1ρ MRI can permit early diagnosis to enable the clinician to organize the treatment plan and avoid further progression of the pathology and dysfunction.