bluuebunny/crossref_metadata_2025 huggingface dataset:
Rumansil I (Murça-do-Douro): um complexo artesanal antigo no Vale do Douro
Authors: Pereira Pedro , Silvino Tony , Sá Coixão António Do Nascimento
Published: October 2020

A zona em torno da vila de Freixo de Numão (Vila Nova de Foz Côa) é sobejamente conhecida pela historiografia clássica devido à presença de uma série de estabelecimentos rurais no seu entorno. Entre os vários sítios romanos, destaca-se Rumansil I pela variedade de atividades aí realizadas: metalurgia de ferro e chumbo, produção cerâmica, tanto de dolia como de peças finas e comuns, e produção de vinho. Os dados disponíveis não permitem a datação do início da construção deste sítio, mas fornecem indicações de que o seu abandono terá ocorrido a partir da segunda metade do século III da nossa Era, com uma ocupação limitada durante o século IV. Rumansil I situa-se num território dominado pelo granito, a poucos quilómetros a Sul do Rio Douro. O estudo deste sítio foi fundamental para compreender a rede de estabelecimentos rurais romanos em torno de Freixo de Numão, local que, aliás, durante muito tempo, se pensava ter sido a capital de um território indígena e que terá jogado um papel importante na organização do espaço rural desta zona do Douro durante a Antiguidade.
Noticia y análisis de un fragmento marmóreo con simbología judía procedente de Mérida
Authors: González Salinero Raúl
Published: October 2020

En el presente artículo se da a conocer la existencia de un nuevo vestigio material de época tardoantigua perteneciente a la comunidad judía emeritense. La singularidad de la menorá que, flanqueada por un sofar y un lulaḅ, se sitúa en el centro del fragmento marmóreo, no sólo avala su carácter genuino, sino que, en combinación con otros argumentos verificables, permite a su vez aventurar una plausible cronología de la pieza (de finales del siglo IV o pleno siglo V E.C.). Partiendo de algunos de los rasgos intrínsecos que presentan los motivos decorativos, es posible también defender la hipótesis de que el fragmento conservado formase parte integrante de una inscripción funeraria desafortunadamente perdida.
O que traz o contexto de uma cadeia produtiva: as relações socioculturais em uma cidade criativa gastronômica. O caso de Burgos, Espanha.
Authors: Junqueira Luiz Daniel Muniz , Dos Anjos Francisco Antonio , Velasco-González María
Published: October 2020

A Unesco reconheceu Burgos em 2015 como uma cidade criativa da gastronomia. Considerando esse reconhecimento, esse estudo buscou identificar características socioculturais na configuração da cadeia produtiva da gastronomia criativa. Para responder a essa proposta, a pesquisa teve como objetivo analisar a dinâmica das relações socioculturais da cadeia produtiva da gastronomia da Província de Burgos. O método adotado baseou-se na abordagem qualitativa, de caráter exploratório, obtendo os dados por meio de entrevistas com atores envolvidos na cadeia podutiva da gastronomia local e em documentos oficiais. Realizou-se, ainda, estudos bibliográficos e documentais para fundamentar a interpretação dos dados, sendo realizado por meio da análise de conteúdo. O resultado obtido identificou que na região de Burgos as relações socioculturais se evidenciam em torno do segmento cultural gastronômico e fortalecem a cadeia produtiva criativa na região.
Turismo de surf: revisión de nuevas líneas y temáticas de investigación (2012-2018)
Authors: Valencia Luis , Osorio García Maribel , Serrano Barquín Rocío Del Carmen
Published: October 2020

El turismo de surf es un fenómeno de gran relevancia a nivel mundial; millones de surfistas se desplazan a diversos destinos con la finalidad de montar la ola perfecta, mejorar sus habilidades, aprender el deporte o simplemente apreciarlo. Sin embargo, aun cuando se han reconocido las características particulares de este nicho de turismo en Iberoamérica, poca atención ha recibido como fenómeno social por parte de la Academia y, por lo tanto, la revisión de su estado de conocimiento ha sido limitada. El presente documento tiene como objetivo presentar las líneas de investigación relacionadas con el turismo de surf durante el periodo 2012-2018, a través de un análisis de contenido aplicado a artículos científicos publicados tanto en inglés como en español. Entre los principales resultados destacan cinco líneas de investigación: 1) El surfista; 2) Turismo de surf, desarrollo local y sustentabilidad; 3) Impactos del turismo de surf; 4) Identidad y género en el turismo de surf; e 5) Historia del surf y stakeholders, las cuales son descritas en este estudio. Cabe señalar que la revisión realizada también permitió identificar autores, universidades y países que han abordado temas relacionados, así como aquellos vacíos de conocimiento que aún persisten sobre este tópico de actualidad.
Informação e comunicação nos postos de turismo do Douro
Authors: Pereiro Xerardo , Sacramento Octávio
Published: October 2020

Os postos de turismo são espaços de hospitalidade, de comunicação com os visitantes e de (re)construção de imagens e experiências do destino, podendo mesmo estimular profundas ligações emocionais com o território visitado. Neste texto analisamos o seu papel de mediação comunicacional entre os visitantes e os destinos a partir de um estudo de caso na região do Douro, no Norte de Portugal. Procuramos, assim, compreender os procedimentos de informação e comunicação turística realizados através dos postos municipais de turismo. De forma complementar, é nosso intuito perceber o processo de transformação de muitos destes postos em lojas interativas de turismo, o que implicou mudanças significativas nos processos e práticas de comunicação com os turistas. Os elementos que sustentam a análise foram proporcionados por um trabalho de terreno de natureza quali-quantitiva e multimetódica, embora a abordagem qualitativa tenha assumido maior destaque. Em concreto, a pesquisa empírica foi realizada através da observação participante, de entrevistas semidirigidas, da netnografia e da pesquisa documental e estatística. Os dados apurados evidenciam a existência de constrangimentos estruturais em muitos dos postos de turismo e, por outro lado, mostram-nos a importância do fator humano nos processos de comunicação turística, o que não deixa de suscitar uma reflexão acerca das valências que estes postos deverão assumir no quadro de uma sociedade digital, atulhada em (des)informação.
Paisaje patrimonial y turismo en la zona precordillerana de Panguipulli, sur de Chile
Authors: Pilquiman Vera Marisela Jeanette , Merino Espeso Alberto , Cabrera Campos Gustavo
Published: October 2020

En la zona precordillerana lacustre del sur de Chile las prácticas culturales de las comunidades mapuche contribuyen a una gestión del paisaje de bajo impacto que ha permitido preservar la riqueza patrimonial natural y cultural de la zona. A través de un enfoque cualitativo de investigación se establece que tal bajo impacto es, en parte, resultado de la relación de convivencia que las comunidades han mantenido con el territorio que habitan. Surge de ello un paisaje patrimonial que, por su carácter y valores relevantes, merece ser objeto de reconocimiento y salvaguarda para garantizar su respeto y conservación frente a la amenaza que significa el desarrollo de una actividad turística fundada en lógicas de mercado hegemónicas que podrían alterar significativamente las características del paisaje analizado.
Microfranquicias: una modalidad de negocio inclusivo turístico para la Guajira, Colombia
Authors: Caridad Migdalia , Castellano María , Bittar Olga
Published: October 2020

El artículo tiene como objetivo analizar la relación entre los negocios inclusivos (NI) y las microfranquicias desde las oportunidades y desafíos que enfrenta la Guajira para incursionar en emprendimientos turísticos. Para este análisis se planteó un análisis descriptivo correlacional con diseño no experimental, transversal de campo. Se aplicó un cuestionario de 25 ítems a 147 sujetos, cuya validez fue aprobada por expertos en el área, mientras que su consistencia arrojó un Alfa de Cronbach de 0,761. Los resultados determinaron que los NI y las microfranquicias se hallan fuertemente asociadas, 873**. Las conclusiones destacan la viabilidad del tipo de NI como proveedores, distribuidores o productores, mientras que en menor grado el tipo de NI como socios o aliados empresariales. En cuanto a los desafíos, el énfasis se sitúa en las políticas públicas para el desarrollo de negocios y el acceso a planes de financiación empresarial. Del lado de las ventajas, el turismo es el eje articulador para que los NI bajo la modalidad microfranquicias incursione en la región Guajira, sin embargo, es necesario abordarlas con acciones que las hagan más eficaces y efectivas. Para ello, se brinda una serie de sugerencias que coadyuven a rebasarlos con el apoyo de todos. El estudio es de gran utilidad para investigadores académicos en el sector negocios y turismo permitiendo deliberar sobre el modelo de microfranquicias como un esquema viable para minimizar las condiciones de pobreza de las personas en la base de la pirámide.
African swine fever: A permanent threat to Indian pigs
Authors: Patil Sharanagouda S. , Suresh Kuralayanapalya Puttahonnappa , Vashist Vikram , Prajapati Awadhesh , Pattnaik Bramhadev , Roy Parimal
Published: October 2020

India has 9 million pigs, of which 45% are in the North eastern (NE) states of India. Viral diseases affecting pigs are a major concern of mortality causing huge loss to the pig farmers. One such disease is African swine fever (ASF) that has already knocked the porous borders of NE states of India. ASF is a highly contagious devastating disease of pigs and wild boars causing 100% mortality. The causative agent African swine fever virus (ASFV) belongs to the genus Asfivirus, family Asfarviridae. Pig is the only species affected by this virus. Soft ticks (Ornithodoros genus) are shown to be reservoir and transmission vectors of ASFV. Transmission is very rapid and quickly engulfs the entire pig population. It is very difficult to differentiate classical swine fever from ASF since clinical symptoms overlap. Infected and in contact pigs should be culled immediately and buried deep, and sheds and premises be disinfected to control the disease. There is no vaccine available commercially. Since its first report in Kenya in 1921, the disease has been reported from the countries in Europe, Russian federation, China, and Myanmar. The disease is a threat to Indian pigs. OIE published the first report of ASF in India on May 21, 2020, wherein, a total of 3701 pigs died from 11 outbreaks (Morbidity - 38.45% and mortality - 33.89%) in Assam and Arunachal Pradesh states of India. ASF is non-zoonotic.
Toward the Development of Iteration Procedures for the Interval-Based Simulation of Fractional-Order Systems
Authors: Rauh Andreas , Kersten Julia
Published: October 2020

In many fields of engineering as well as computational physics, it is necessary  to describe dynamic phenomena which are characterized by an infinitely long horizon of past state values. This infinite horizon of past data then influences the evolution of future state trajectories. Such phenomena can be characterized effectively by means of fractional-order differential equations. In contrast to classical linear ordinary differential equations linear fractional-order models have frequency domain characteristics with amplitude responses that deviate from the classical integer multiples of ±20 dB per frequency decade and, respectively, deviate from integer multiples of ±π/2 in the limit values of their corresponding phase response. Although numerous simulation approaches have been developed in recent years for the numerical evaluation of fractional-order models with point-valued initial conditions and parameters, the robustness analysis of such system representations is still a widely open area of research. This statement is especially true if interval uncertainty is considered with respect to initial states and parameters. Therefore, this paper summarizes the current state-of-the-art concerning the simulation-based analysis of fractional-order dynamics with a restriction to those approaches that can be extended to set-valued (interval) evaluations for models with bounded uncertainty. Especially, it is shown how verified simulation techniques for integer-order models with uncertain parameters can be extended toward fractional counterparts. Selected linear as well as nonlinear illustrating examples conclude this paper to visualize algorithmic properties of the suggested interval-based simulation methodology and point out directions of ongoing research.
Bolsonarismo: a necropolítica brasileira como pacto entre fascistas e neoliberais
Authors: Silva Júnior João dos Reis , Fargoni Everton Henrique Eleutério
Published: October 2020

O texto analisa as mudanças e crises no sistema político brasileiro e suas consequências na sociedade civil e produção científica com a vitória de Bolsonaro nas eleições [presidenciais] de 2018.  A partir da discussão de elementos históricos e recentes, este artigo busca compreender e debater as razões e transformações na sociedade brasileira que formaram o intento eleitoral que caracterizaram o Bolsonarismo. Mostra que este movimento é também responsável por um dos períodos mais dramáticos para a história política do país. Finaliza analisando a ruptura da estabilidade política brasileira, ataques às instituições, crise econômica e politização da ciência sob ataque ideológico por meio do pendular estreitamento do Bolsonarismo com o fascismo.
Increased Efficiency of a Current Compensating Load Modulation Based MMIC Doherty Power Amplifier Design In 0.25m GaAs pHEMT Technology
Authors: Rouhani Seyedehmarzieh , Rouhi Kasra , Abrishamifar Adib , Tayarani Majid
Published: October 2020

In this work, a premise is applied to the conventional load modulation equation of Doherty power amplifier (DPA) in 0.25 m GaAs pHEMT technology to compensate output impedance of main amplifier ( Z
out,main) variation, even in low power region. Using this modified modulation leads to the DPAs power added efficiency (PAE) increase in comparison by the case in which the load modulation revision is ignored, which is also designed in this paper. Second harmonic rejection networks are also added to both designs to play their roles as to efficiency increase. By doing so, the revised load modulation based DPA has the maximum PAE of 39.6%, maximum output power ( P
out ) of 31.61dBm, at 8 GHz. Simulation results of this DPA in higher harmonics indicate the designed DPA has the minimum second and third harmonics power of -51.7 dBm and -80 dBm, respectively. For the sake of linearity evaluation, it is depicted that 1dB-power gain compression has not occurred in the input power (P
in ) range in which the proposed DPA works.
A desigualdade entre países do Sul-Sul com relação ao direito à saúde
Authors: Zina Faz-Ver Domingos Pedro , Rosaneli Caroline Filla
Published: October 2020

A desigualdade entre países demonstra a fragilidade que a humanidade vivencia em defesa aos direitos humanos. Este texto tem o objetivo de fazer uma análise reflexiva sobre o acesso à saúde em países do sul global, especificamente uma breve análise do Brasil e Moçambique. O texto procura ponderar sobre as populações mais vulneráveis destes dois países, baseando a discussão sobre a proteção dos direitos dos povos na Declaração Universal sobre Bioética e Direitos humanos, e também como referência na defesa do Objetivos do Desenvolvimento Sustentável. Ambos países necessitam produzir padrões mais favoráveis a equidade em saúde, considerando que vidas humanas precisam ser poupadas por ações éticas e urgentes.
Mehandi in the Marketplace
Authors: Evans Jain Jessica
Published: October 2020

Henna has been an essential part of women’s traditional body art in many North Indian communities. In recent decades, professional henna artists have expanded their businesses to offer “walk-in” service along the sidewalks of urban market areas in addition to private at-home bookings. This study examines the skills acquisition and execution of Jaipur market henna artists in order to understand how they satisfy a large customer base that demands convenience, application speed, motif variety, and overall design excellence. In addition to conducting interviews with artists and customers, the author received training from and worked alongside a closed sample of artists. Collected market designs were compared to surveyed design booklets and magazines in order to identify elements of continuity and change in designs since 1948. The data revealed that customer demands require artist training that promotes constant innovation that in turn increases popular appeal and vitalizes the tradition of henna application.
The effects of sports participation on internet addiction of high school students
Authors: Aycan Ali , Üzüm Hanifi
Published: October 2020

The purpose of this study was to investigate the effects of sport participation status on internet addiction of high school students. The sample group consisted of total 430 students (220 licensed student athletes and 210 non-athletes) from 10 different high schools in Bolu center. Research data were obtained by “Young Internet Addiction Test Short Form” (YIBT-KF) which was adapted to Turkish by Kutlu Savcı, Demir ve Arslan (2016). Internal consistency of the scale was calculated as α= 0.93 in this study. The results of this study showed that a) internet addiction levels of male students were lower than female students, b) internet addiction levels of athlete students were lower than non-athlete students, c) academic success for athlete students were more positive effect in internet addiction and d) the negative effect of long-term usage a smart phone had less negative effect on internet addiction level of athlete students. ​Extended English summary is in the end of Full Text PDF (TURKISH) file.   Özet   Bu çalışmada, lise öğrencilerinin spora katılım durumlarının internet bağımlılıklarına etkisinin incelenmesi amaçlanmıştır. Bolu merkezindeki 10 farklı liseden toplam 430 öğrenci (220 lisanlı spor yapan ve 210 lisanslı olarak spor yapmayan) çalışmanın örneklem grubunu oluşmuştur. Çalışma verilerinin toplanmasında, Kutlu, Savcı, Demir ve Arslan (2016) tarafından Türkçeye uyarlanan “Young İnternet Bağımlılığı Testi Kısa Formu” (YİBT-KF) kullanılmıştır. Bu çalışma için ölçeğin Cronbach Alpha iç tutarlılık değerleri ise α=0.93 olarak hesaplanmıştır. Araştırmada,  a) spor yapan öğrencilerin internet bağımlılıklarının yapmayanlardan daha düşük olduğu sonucuna ulaşılmıştır. b) erkek öğrencilerin internet bağımlılık düzeylerinin kadın öğrencilerden daha düşük olduğu, c) spor yapanlarda yapmayanlara göre akademik başarının internet bağımlılığında daha etkili olduğu ve d) spor yapanlarda yapmayanlara göre cep telefonu kullanım yılının internet bağımlılığına etkisinin daha az olduğu sonucuna ulaşılmıştır.
Household-Level Effects of Energy Insecurity on Welfare in Southern Africa: A Malawian Case Study
Authors: Mkomba Fydess Khundi , Saha Akshay Kumar , Wali Umaru Garba
Published: October 2020

The debate of energy security has, over the past decades, centered on supply factors within the energy policy framework in the public policy discourse. Much more empirical evidence is required to fully understand  the household-level effects of energy security on development outcomes. This paper explores the  characteristics of the households that face energy insecurity and also analyze the effects of energy insecurity on household welfare using the recent data from the Malawi Fourth Integrated Household Survey(IHS4) 2016-2017. Overall, 42.58% of Malawian households were found to be  energy insecure and the study findings show that the energy insecure were a heterogenous group compared to the energy secure. The heterogeneity exist because  of differences in demographics (likely to be advanced in age, likely to be females,  less likely to have a household head  with  formal education); socioeconomic status (likely to be poor,  had low wealth  levels); geography (likely to be rural dwellers in the central and southern parts of Malawi); housing and dwelling status (less likely to be renters, less likely to be found in permanent or semi-permanent buildings that have iron sheets and cement floor). Additional results from econometric analysis showed that energy insecure households reduced their food consumption by 2.3% for each 1% unit increase in the share of the energy costs in their total household budget. Similarly, on the education outcome, the energy insecure households reduced  their education expenditure by 3.6% for each 1% unit increase in the share of the energy costs over the total household expenditure. These findings show that energy security plays a key role towards improvement of household welfare in general as this might have short term and long-term negative implications on human capital development.
JOINT DEVELOPMENT AGREEMENT SEBAGAI SOLUSI PENYELESAIAN SENGKETA WILAYAH ZONA EKONOMI EKSKLUSIF LAUT NATUNA
Authors: Andaru Djarot Dimas Achmad
Published: October 2020

Permasalahan sengketa pada perairan zona ekonomi eksklusif Laut Natuna antara Indonesia dan China merupakan bagian dari sengketa klaim wilayah Laut Natuna. China mengklaim Laut Natuna Utara atas dasar kebijakan nine-dash line. Perairan Natuna diprediksi menyimpan sumber daya alam hidrokarbon dengan kapasitas 11 billion barrel. Solusi hukum yang dapat menjadi solusi di wilayah tersebut adalah melalui pembuatan kerjasama pengembangan (joint development agreement) atau JDA. Agar terlaksana secara efektif Indonesia perlu memperhatikan beberapa aspek seperti political will, stigma domestik dan pemahaman negara terkait perancangan JDA. Dengan metode yuridis-normatif, komparatif terhadap peraturan internasional maupun kebijakan internasional beserta perundang-undangan. Artikel ini akan memberikan rekomendasi kepada Indonesia bahwa pemanfaatan sumber daya Laut Natuna dapat dilaksanakan melalui JDA dengan China walaupun berada dalam status sengketa dengan memperhatikan tetap mempertahankan status quo.
PENERAPAN KONSEP OMNIBUS LAW PADA PENGATURAN KEWENANGAN PENEGAKAN HUKUM DI LAUT
Authors: Puspitawati Dhiana
Published: October 2020

Konsep omnibus law yang dianggap dapat menjadi solusi pada permasalahan yang timbul akibat adanya pengaturan yang tumpang tindih, juga akan diterapkan pada tata kelola laut khususnya di bidang penegakan hukum di laut. Artikel ini akan menganalisis apakah penerapan konsep omnibus law tepat bila dilakukan pada aspek penegakan hukum di laut. Metode yang digunakan dalam artikel ini adalah yuridis normatif dengan pendekatan perundang-undangan. Meskipun terdapat tumpang tindih pengaturan dalam penegakan hukum di laut, penerapan konsep omnibus law dalam hal penegakan hukum tidaklah tepat. Hal ini dikarenakan adanya pengaturan UNCLOS 1982 tentang zona maritim yang mengakui hak-hak negara lain di wilayah laut, baik wilayah laut yang merupakan kedaulatan negara pantai maupun wilayah yurisdiksi negara pantai. Diperlukan harmonisasi dan revisi peraturan perundang-undangan terkait penegakan hukum di laut.
A new distributional record of Ficus altissima Blume (Moraceae) in Tripura: an occasionally confused fig species with Ficus benghalensis L.
Authors: Banik Biplab , Debbarma Smita , Majumdar Koushik , Datta Badal Kumar
Published: October 2020

The present communication is the first report of new distributional record of Ficus altissima Blume (Moraceae) in Tripura. F. altissima was found to be an important feeding and nesting habitat for forest frugivores, since the genus is very rich in diversity and is considered as a keystone species. This also possesses huge scope to understand the mechanism of interactions especially for conservation of rich avifaunal diversity. Brief description and field photographs are presented for facilitating easy identification of the species.
Культурная идентичность в процессе русско-польского перевода
Authors: Jóźwiak Jolanta
Published: October 2020

The article deals with the issue of transferring intertextual cultural elements in the process of translation from Russian into Polish. The material for analysis is the fragments of the novel The Black City by Boris Akunin and its translation into Polish by Aleksandra Okuniewska-Stronka. The aim of this article is to present and evaluate the results of transferring cultural connotations and intertextual references from one culture to another. Cultural elements play a significant role in the process of the reception of the text and its translation both by the readers of the original text ‒ native language users – and by the recipients of the translated variant, belonging to a different culture. The comparison of source units and translated target units shows how different the associative circles arising in the process of text reception are. The analysis leads to the conclusion that taking into account the associative and intertextual potential of language units in translation is a very complex process. It requires a double cultural competence from the translator, and involves not only the interpretation of language signs in terms of their cultural code, but also the assessment of the interpretative abilities and capabilities of the recipients.
Особенности образа современного русского интеллигента на примере романа Алексея Варламова Затонувший ковчег (1997)
Authors: Królikiewicz Natalia
Published: October 2020

The article focuses on the image of the modern Russian intellectual, depicted in the artistic text of Aleksey Varlamov, the Sunken Ark. Understanding the phenomenon of the Russian intelligentsia in the analysed literary work is associated with the problem of the opposition of reason and faith in the process of the personality formation of the modern intellectual. The analysis carried out in the text allows not only to trace and better understand the social processes of the crisis period in Russia, but also to notice their enormous impact on the consciousness of the main hero-intellectual Ilya Petrovich. The use of the methodology of historical and literary research in the work is adequate to the problems posed. The novel under analysis, as a kind of warning, has a deep philosophical undertone that touches upon the problems of faith, unbelief, freedom of the individual and the pursuit of moral perfection. Varlamov’s intellectual, as a typical “hero of our time”, regardless of his weakness, defenselessness and internal rupture, seems to be most needed in life.
IGF1 for the diagnosis of growth hormone deficiency in children and adolescents: a reappraisal
Authors: Ibba Anastasia , Corrias Francesca , Guzzetti Chiara , Casula Letizia , Salerno Mariacarolina , di Iorgi Natascia , Tornese Gianluca , Patti Giuseppa , Radetti Giorgio , Maghnie Mohamad , Cappa Marco , Loche Sandro
Published: October 2020

A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two children and adolescents with GHD ((63 organic/genetic (OGHD), 79 idiopathic (IGHD)) and 658 short non-GHD children (median age 10.4 years) were included in the analysis. The two groups were subdivided according to age (G1 <6, G2 6 <9, G3 9 <12, G4 ≥12) and to pubertal status. Serum IGFI was measured by the same chemiluminescence assay in all samples and expressed as age- and sex-based SDS. Receiver operating characteristic (ROC) analysis was used to evaluate the optimal IGF1 SDS cut-off and the diagnostic accuracy. Median IGF1 SDS was significantly lower in the GHD than in non-GHD patients. The area under the curve (AUC) was 0.69, with the best IGF1 cut-off of −1.5 SDS (sensitivity 67.61%, specificity 62.62%). The AUC was 0.75 for OGHD and 0.63 for IGHD. The accuracy was better in the pubertal (AUC = 0.81) than the prepubertal group (AUC = 0.64). In our cohort, IGF1 measurement has poor accuracy in discriminating GHD from non-GHD. Our findings confirm and reinforce the belief that IGF1 values should not be used alone in the diagnosis of GHD but should be interpreted in combination with other clinical and biochemical parameters.
“A Rare Creature, in Mind, in Heart, in Character” (a Relative of Dostoevsky From Siberia)
Authors: Panyukova Tatyana
Published: October 2020

The article presents the unknown facts in the biographies of people in the family circle of F. M. Dostoevsky: his sister-in-law Olga Kirillovna Snitkina and her mother Nadezhda Ivanovna Obraszhova. His first acquaintance with them belongs to the Dresden period of the writer's life (1869–1870). The sparse information that is currently available about their lives was drawn mainly from Dostoevsky's correspondence with his wife and belongs to a later period. Based on a systematic analysis of the preserved correspondence of the Snitkin family (relatives of the writer's wife), memoirs of contemporaries, genealogical and local history materials, as well as archival searches, their biographies were reconstructed, several unknown documentary sources were introduced into scientific circulation (stored in the Fund of the Department of Heraldry of the Russian State Historical Archive and in the Fund of the St. Petersburg Spiritual Consistory of the Central State Historical Archive of St. Petersburg), the exact date (May 17, 1873), and the place of birth of one of Anna Grigoryevna Dostoevskaya's nephews — Vanya Snitkin, as well as the maiden name of his mother Olga Kirillovna (née Maryina) were established. The study showed that the lineage of O. K. Snitkin and N. I. Obraszhovoy descends from Siberia and includes representatives of several famous merchant dynasties of the mid-XIX сentury. A brief textual description of the surviving correspondence between this branch of the Snitkin family and the Dostoevsky family is attached to the article.
Complete Remission of Advanced Hepatocellular Carcinoma Treated with Sorafenib and Concomitant Appearance of IgG4- related Diseases. A Case Report
Authors: Impellizzeri Giovanna , Renzulli Matteo , Azzaroli Francesco , Golfieri Rita , Mazzella Giuseppe , Marasco Giovanni
Published: October 2020

Sorafenib is currently the gold standard therapy for palliative treatment of advanced hepatocellular carcinoma (HCC) in patients with compensated liver disease. There are few cases reported in literature describing patients with HCC achieving a complete remission (CR) due to Sorafenib therapy. We report the case of a 62-year old patient who obtained CR despite single, long drug discontinuation and kept it without any maintenance therapy. Furthermore, this is the first case describing the onset of a likely IgG4-related retroperitoneal fibrosis and cholangitis during Sorafenib administration. Further studies are required to define the predictors of a good response to Sorafenib and to codify a therapeutic maintenance regimen for patients who achieve CR.
Evaluation of the Association between Programmed Cell Death-1 Gene Polymorphisms and Hepatocellular Carcinoma Susceptibility in Turkish Subjects. A Pilot Study
Authors: Demirci Abdullah Fatih , Demirtas Coskun Ozer , Eren Fatih , Yilmaz Demet , Keklikkiran Caglayan , Ozdogan Osman Cavit , Gunduz Feyza
Published: October 2020

Background and Aims: Programmed cell death-1 (PD-1) has a vital role in regulating T-cell function, and immune escape mechanism of cancer cells. It was shown that there could be a relationship between single nucleotide polymorphisms (SNPs) in the PD-1 gene and susceptibility to hepatocellular carcinoma (HCC) based on various studies. We aimed to investigate the role of three SNPs within the PD-1 gene in susceptibility to HCC in the Turkish population.

Methods: Single nucleotide polymorphisms of PD-1.1, 1.5, and 1.6 were genotyped by using TaqMan Allelic Discrimination Assays in blood samples of 137 HCC and 136 control subjects, matched for age and gender. The genotype, allele and haplotype frequencies were compared in HCC and control groups using logistic regression analysis.

Results: Genotype distributions of PD-1.1, PD-1.5 and PD-1.6 SNPs were in Hardy-Weinberg equilibrium. No significant difference was observed in the genotype distribution of PD-1.1, PD-1.5 and PD-1.6 polymorphisms among gender and age-matched HCC (M/F: 96/41; mean age: 61.4 ±11.7 years) and control group (M/F: 94/42; mean age: 61.4±10.1). In the haplotype analysis of PD-1.1/PD-1.5/PD-1.6, no significant difference was found among HCC and control group adjusted for sex and age (all p values>0.1).

Conclusion: Our findings, firstly reporting the association of PD-1.5 polymorphism with HCC, and PD-1.1 and PD-1.6 with HCC in the Turkish population, suggest that PD-1 polymorphisms are not predisposing factors for HCC development. Future studies with larger sample sizes and different ethnic populations are required to validate our findings.
Clinical and Manometric Characteristics of Patients with Achalasia: One Disease with Three Presentations or Three Diseases with One Presentation?
Authors: Surdea-Blaga Teodora , David Liliana , Pop Andrei , Tantau Marcel , Dumitrascu Dan Lucian
Published: October 2020

Background and Aims: The three manometric patterns of achalasia are considered by some authors as different stages in the evolution of the same disorder. The aims of our study were to characterize patients with achalasia, in order to find key differences supporting the idea of progression from one type to the other, and to assess the clinical evolution in time.

Methods: From 280 high resolution esophageal manometry recordings we selected unique patients with achalasia. A standardized questionnaire used prior to each manometry recorded their symptoms. Manometric parameters (resting lower esophageal sphincter (LES) pressure, 4s-integrated relaxation pressure (IRP), length of the esophagus, etc.) were recorded. Patients were contacted to establish the clinical evolution.

Results: We identified 108 new achalasia cases (mean age 48.2±16.2 years, 52.8% type I, 42.6% type II), 52 (48.1%) women. Dysphagia (98.1%), cough (64.8%), belching (60.2%) and reflux symptoms (53.7%) were frequently reported. Patients with type I achalasia reported more often that dysphagia worsened, compared to type II patients (χ2=7.3, p =0.007). Age, duration of dysphagia, body mass index (p=0.067) and esophageal length were similar in type I and type II achalasia. Resting LES pressure (64.7±22.6 mmHg vs. 54.3±21.6 mmHg, p=0.019) and 4s-IRP (45.3±17.6 mmHg vs. 38.4±15.5 mmHg, p=0.036) were higher in type II compared to type I achalasia. Overweight patients had a lower LES resting pressure and 4s-IRP compared to lean subjects. After a mean follow-up of 36.8±13.4 months, 49 (45.3%) patients responded to our follow-up, and 77.5% had an Eckardt score ≤ 3.

Conclusions: Type I achalasia was the most common in our group. Type I patients had lower BMI but similar duration of dysphagia and mean age compared to type II. Type III is seldom and present in older patients. These findings suggest low probability of progression from type III and II to type I achalasia. Patients with type II achalasia had higher resting LES pressure and 4s-IRP than type I achalasia patients.
Morphological adaptation of borrowed nouns with final -o in Ukrainian: a corpus-based study
Authors:   Kyiv National Linguistic University, Shvedova Mariiа
Published: October 2020

The paper describes the use of declined and invariable paradigms of borrowed nouns with the final –o (of the type avto ‘car’, bjuro ‘bureau, office’) exemplified by the General regionally annotated corpus of the Ukrainian language (GRAC, uacorpus.org). The texts of different styles from different regions of Ukraine and the diaspora, written from the end of the 19th to the beginning of the 21st century, are analyzed. The degree of variability and stylistic markedness of competing morphological forms are shown depending on the time and place of creation of the texts in question. The declension of borrowed words with the final –o was acceptable as an option in Ukraine until about the end of the Second World War, then practically absent in the Soviet texts of 1950–1990, and after 1991 the share of this variant again increases slightly. According to the official norm, in the post-war period in Ukraine the invariable paradigm of the borrowed nouns with the final –o, with the single exception of pal’to ‘coat’, was the only option. The inflected variants were rarely used at this time in Soviet texts, usually as a marker of colloquial style. In the language of the diaspora, the tendency to inflect the borrowed nouns with the final –o is stronger, there was no stylistic difference between the inflected and non-inflected variants. In the modern Ukrainian language in Ukraine, the inflected variants of borrowed nouns in many cases retain stylistic markedness, signalling the Western Ukrainian influence, the diaspora tradition or a sign of departure from the Soviet norm. A study of contemporary Kiev and Lviv newspapers has shown that regional differences in the use of these grammatical variants are virtually absent in nonfiction texts. Normative invariable forms prevail in both editions, therefore, the inflected forms in modern journalism can be considered a purely stylistic variant. Keywords: Ukrainian grammar, diachronic evolution, corpus, declension, morphology, borrowings.
Uzual and occasional word-formation in different style language practice
Authors:   Institute of the Ukrainian Language of National Academy of Sciences of Ukraine, Kysliuk Larysa
Published: October 2020

The article considers the manifestation of the interaction of the usual and the occasional in language practice through the transition of a text word to the system of language. Stylistic features of the functioning of occasional derivatives in journalistic, artistic, scientific texts are analyzed. A transitional zone in the functioning of usual and occasional units in the texts of mass media and fiction has been identified, which can be defined as an expansion of the derivation base of the model or as a repeated violation of the compatibility of components in the word-forming model. Such derivative units can be considered both casual and occasional. The factor of time and the spread of a phenomenon in the community influence the transition of some occasionalisms to the status of neologisms (комп’ютеризація). Peculiarities of creation and functioning of occasional derivatives in journalistic, artistic and scientific texts are analyzed. Active models in the media work to create occasionalisms that are important for the linguistic picture of society (albeit in a very short time, because they relate to a particular event or situation: ректоропад, банкопад, нафтопад). In fiction, poetry, the naming of a certain phenomenon is important primarily for the person of the author (всебезодня, всемежа in Vasyl Stus). Therefore, the word-forming model, which is a defining marker, a characteristic feature of creativity of one author, is not so important in the set of texts of the same style, and is often a random, peripheral phenomenon for usus. The phenomenon of occasional creation of terms of informatics, IT, socio-political sphere is a renewal of the tradition of “forged words” («кованих слів») in the Ukrainian language. A modern author’s innovation can spread in usus, become a terminoid and has a chance to enter in the terminological dictionaries (моментократія, застосунок). However, the conscious creation of a term on a origional basis (шкул, дошкуляч) often has no chance to be ususalized as a term as opposed to widespread internationalism (спам) due to the broad meaning of the producing verb (дошкуляти). Keywords: word-forming model, occasional word-formation, occasional word, potential word, “forged” word.
Fetal Inflammatory Response Syndrome Associated With Maternal SARS-CoV-2 Infection
Authors: McCarty Kyra L. , Tucker Megan , Lee Gene , Pandey Vishal
Published: October 2020

Amid the coronavirus disease 2019 pandemic, uncertainty exists about the potential for vertical transmission from mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the fetus in utero. In this case report, we aim to demonstrate the occurrence of a fetal inflammatory response syndrome associated with maternal SARS-CoV-2 infection resulting in neonatal morbidity. In this report we describe an infant of a SARS-CoV-2–positive mother born prematurely with late-onset fever, thrombocytopenia, and elevated levels of inflammatory markers, all of which are consistent with a systemic inflammatory response. The neonate was tested for SARS-CoV-2 by using 2 nasopharyngeal swabs 24 hours apart, and results of both were negative. The result of a full workup for additional infectious pathogens was also negative. Although initially in critical condition in the perinatal period, the infant recovered completely before discharge. We hypothesize that this systemic inflammation occurred in response to maternal viral infection in the absence of vertical transmission of the virus. During the coronavirus disease 2019 pandemic, it will be important to consider the virus as a nidus for a fetal inflammatory response syndrome and resulting morbidity, even in the setting of a negative SARS-CoV-2 testing result in the infant.
Endometrial hyperplasia (Clinical lecture)
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv, Vovk I.B. , Gorban N.Е. ,   SI Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv, Borysiuk O.Ju. ,   SI Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv
Published: October 2020

In clinical lecture presents modern views of endometrial hyperplasia in terms of practitioner gynecologist. The problems of classification, pathogenetic mechanisms of development of endometrial hyperplasia. Particular attention is paid to modern approaches to diagnosis and treatment of endometrial hyperplasia. Key words: hyperplasia, endometrium, classification, endometrial hyperplasia, endometrial intraepithelial neoplasia, hormonal therapy.
Delayed interval delivery of the second and third fetuses in multiple pregnancy triplet (Сase report)
Authors:   Dnepropetrovsk State Medical Academy, Ukraine, Dubossarskaya Y. , Padalko L. ,   РІ Dnipropetrovsk regional perinatal center with a hospital, Ukraine, Zakharchenko L. ,   РІ Dnipropetrovsk regional perinatal center with a hospital, Ukraine, Savel’eva E. ,   РІ Dnipropetrovsk regional perinatal center with a hospital, Ukraine
Published: October 2020

This article describes a clinical case of vaginal delivery in nulliparous women 24 years old delayed interval delivery of the second and third fetuses in spontaneous multiple pregnancy dichorionic triamniotic triplet in a tertiary perinatal center. After preterm delivery in 27+5 weeks of gestation the first fetus to reduce perinatal morbidity and mortality of two fetuses that are left in the uterus, with informed consent of the woman preterm delivery the second and third fetuses occurred at intervals of 38 days, in 33+1 weeks of gestation. Careful monitoring of the state of the mother and fetuses was conducted. To increase the interval between the birth of the first fetus and the second and the third fetuses, prevention of obstetric and perinatal complications used tocolysis, antibiotics, progesterone, the prevention of respiratory distress syndrome of the newborn by corticosteroids and bed rest. Three girls were born alive with a weight of 980, 1800 and 1950 grams correspondingly. Childbirth complicated second degree perineal laceration and retained portions of placenta and membranes, puerperal period was uneventful. After 1.5 months, all infants discharged with her mother in a satisfactory condition with a weight of more than 3000 grams. Key words: multiple pregnancy, triplet pregnancy, delayed interval delivery in triplet pregnancy, preterm delivery.
The role of inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy as a result of ART
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Ventskivskiy B.M. , Poladych I.V. ,   Bogomolets National Medical University, Kyiv, Ukraine, Avramenko S.O. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: October 2020

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.
Instagram w autoprezentacji politycznej. Analiza wizualna postów polskich kandydatów do europarlamentu w 2019 roku
Authors:   Instytut Nauk Socjologicznych i Pedagogiki, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Polska, Kampka Agnieszka , Molek-Kozakowska Katarzyna ,   Instytut Językoznawstwa, Uniwersytet Opolski, Polska
Published: October 2020

This article reviews currently available literature on the role of Instagram in political communication and reports on the results of the analysis of 1976 Instagram posts of the most active politicians during the 2019 European parliamentary election campaign in Poland. With the aid of quantitative thematic analysis and qualitative visual rhetorical analysis, we identify the main patterns of self-representation of candidates and compare the forms of visualization and typical strategies of building ethos and mobilizing the voters across parties. We prove that traditional representations of candidates (delivering speeches, canvassing, shaking hands) and national (rather than European) symbols tend to dominate. We conclude with observations on the increase in personalization of politics, professionalization of political campaigning, and strong communitarian identification.