bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Study of Ge-DLC Nanocomposite Biomaterials Prepared by Laser Codeposition
Authors: Jelinek Miroslav , Kocourek Tomáš , Jurek Karel , Jelinek Michal , Smolková Barbora , Uzhytchak Mariia , Lunov Oleg
Published: March 2019

This paper deals with the synthesis and study of the properties of germanium-doped diamond-like carbon (DLC) films. For deposition of doped DLC films, hybrid laser technology was used. Using two deposition lasers, it was possible to arrange the dopant concentrations by varying the laser repetition rate. Doped films of Ge concentrations from 0 at.% to 12 at.% were prepared on Si (100) and fused silica (FS) substrates at room temperature. Film properties, such as growth rate, roughness, scanning electron microscopy (SEM) morphology, wavelength dependent X-ray spectroscopy (WDS) composition, VIS-near infrared (IR) transmittance, and biological properties (cytotoxicity, effects on cellular morphology, and ability to produce reactive oxygen species (ROS)) were studied in relation to codeposition conditions and dopant concentrations. The analysis showed that Ge-DLC films exhibit cytotoxicity for higher Ge doping.
Reactivity of Atomically Functionalized C-Doped Boron Nitride Nanoribbons and Their Interaction with Organosulfur Compounds
Authors: Villanueva-Mejia Francisco , Navarro-Santos Pedro , Rodríguez-Kessler Peter Ludwig , Herrera-Bucio Rafael , Rivera José Luis
Published: March 2019

The electronic and reactivity properties of carbon doped (C-doped) boron nitride nanoribbons (BNNRs) as a function of the carbon concentration were investigated in the framework of the density functional theory within the generalized gradient approximation. We found that the main routes to stabilize energetically the C-doped BNNRs involve substituting boron atoms near the edges. However, the effect of doping on the electronic properties depends of the sublattice where the C atoms are located; for instance, negative doping (partial occupations of electronic states) is found replacing B atoms, whereas positive doping (partial inoccupation of electronic states) is found when replacing N atoms with respect to the pristine BNNRs. Independently of the even or odd number of dopants of the C-doped BNNRs studied in this work, the solutions of the Kohn Sham equations suggest that the most stable solution is the magnetic one. The reactivity of the C-doped BNNRs is inferred from results of the dual descriptor, and it turns out that the main electrophilic sites are located near the dopants along the C-doped BNNRs. The reactivity of these nanostructures is tested by calculating the interaction energy between undesirable organosulfur compounds present in oil fuels on the C-doped BNNRs, finding that organosulfur compounds prefer to interact over nanosurfaces with dopants substituted on the B sublattice of the C-doped BNNRs. Most importantly, the selective C doping on the BNNRs offers the opportunity to tune the properties of the BNNRs to fit novel technological applications.
Construction of Novel Polymerizable Ionic Liquid Microemulsions and the In Situ Synthesis of Poly(Ionic Liquid) Adsorbents
Authors: Wang Aili , Li Shuhui , Chen Hou , Liu Ying , Peng Xiong
Published: March 2019

This paper reports the successful construction of novel polymerizable ionic liquid microemulsions and the in situ synthesis of poly(ionic liquid) adsorbents for the removal of Zn2+ from aqueous solution. Dynamic light-scattering data were used to confirm the polymerization media and to illustrate the effect of the crosslinker dosage on the droplet size of the microemulsion. FTIR and thermal analysis were employed to confirm the successful preparation of the designed polymers and characterize their thermostability and glass transition-temperature value. The optimization of the adsorption process indicates that the initial concentration of Zn2+, pH, adsorbent dosage and contact time affected the adsorption performance of poly(ionic liquid)s toward Zn2+. Furthermore, our research revealed that the adsorption process can be effectively described by the pseudo second-order kinetic model and the Freundlich isotherm model.
Higher Maternal Diet Quality during Pregnancy and Lactation Is Associated with Lower Infant Weight-For-Length, Body Fat Percent, and Fat Mass in Early Postnatal Life
Authors: Tahir Muna J. , Haapala Jacob L. , Foster Laurie P. , Duncan Katy M. , Teague April M. , Kharbanda Elyse O. , McGovern Patricia M. , Whitaker Kara M. , Rasmussen Kathleen M. , Fields David A. , Jacobs David R. , Harnack Lisa J. , Demerath Ellen W.
Published: March 2019

Maternal pregnancy nutrition influences fetal growth. Evidence is limited, however, on the relationship of maternal diet during pregnancy and lactation on infant postnatal growth and adiposity. Our purpose was to examine associations between maternal diet quality during pregnancy and lactation with offspring growth and body composition from birth to six months. Maternal diet quality was serially assessed in pregnancy and at one and three months postpartum, using the Healthy Eating Index–2015 in a cohort of 354 fully breastfeeding mother–infant dyads. Infant length-for-age (LAZ), weight-for-age (WAZ), and weight-for-length (WLZ) Z-scores were assessed at birth, one, three, and six months. Infant body fat percent (BF%), fat mass (FM), and fat-free mass (FFM) were measured at six months using dual-energy X-ray absorptiometry. Higher maternal diet quality from pregnancy through three months postpartum was associated with lower infant WLZ from birth to six months (p = 0.02) and BF% at six months (p ≤ 0.05). Higher maternal diet quality at one and three months postpartum was also associated with lower infant FM at six months (p < 0.01). In summary, maternal diet quality during pregnancy and lactation was inversely associated with infant relative weight and adiposity in early postnatal life. Additional research is needed to explore whether associations persist across the life course.
Can Lycopene Impact the Androgen Axis in Prostate Cancer?: A Systematic Review of Cell Culture and Animal Studies
Authors: Applegate Catherine C. , Rowles Joe L. , Erdman John W.
Published: March 2019

First-line therapy for advanced or metastatic prostate cancer (PCa) involves the removal of tumor-promoting androgens by androgen deprivation therapy (ADT), resulting in transient tumor regression. Recurrent disease is attributed to tumor adaptation to survive, despite lower circulating androgen concentrations, making the blockage of downstream androgen signaling a chemotherapeutic goal for PCa. Dietary intake of tomato and its predominant carotenoid, lycopene, reduce the risk for PCa, and preclinical studies have shown promising results that tomato and lycopene can inhibit androgen signaling in normal prostate tissue. The goal of this systematic review was to evaluate whether mechanistic evidence exists to support the hypothesis that tomato or lycopene interact with the androgen axis in PCa. Eighteen studies (n = 5 in vivo; n = 13 in vitro) were included in the final review. A formal meta-analysis was not feasible due to variability of the data; however, the overall estimated directions of effect for the compared studies were visually represented by albatross plots. All studies demonstrated either null or, more commonly, inhibitory effects of tomato or lycopene treatment on androgen-related outcomes. Strong mechanistic evidence was unable to be ascertained, but tomato and lycopene treatment appears to down-regulate androgen metabolism and signaling in PCa.
The Association between Mineral and Trace Element Concentrations in Hair and the 10-Year Risk of Atherosclerotic Cardiovascular Disease in Healthy Community-Dwelling Elderly Individuals
Authors: Choi Hye-In , Ko Hae-Jin , Kim A-Sol , Moon Hana
Published: March 2019

This cross-sectional analysis included 137 Korean subjects aged 60–79 years. All subjects underwent anthropometric measurements and laboratory tests. Scalp hair samples were obtained from each individual, the concentrations of 36 minerals and trace elements were analyzed, and 16 ratios of elements were calculated. ASCVD risk was estimated using pooled cohort ASCVD risk assessment equations for 10-year risk profiles. The 137 subjects were divided into three risk groups: low (<5%, n = 28), intermediate (5% to <7.5%, n = 21), and high (≥7.5%, n = 88) risk groups. After adjusting for obesity (BMI ≥ 25 kg/m2) and sex, Na concentration (mg%) in hair was significantly lower in the low-risk (13.91 ± 7.02) than in the intermediate-risk (47.18 ± 8.08) and high-risk (36.76 ± 3.95) groups (p for trend = 0.024). The concentration of K (mg%) in hair was also positively associated with the severity of ASCVD risk (10.50 ± 8.37, 23.62 ± 9.63, 33.31 ± 4.71, respectively; p for trend = 0.017), but their differences were not statistically significant (p = 0.059). By contrast, the levels of Co, U, and Hg, and the Ca/P and Ca/Mg ratios, were negatively correlated with the severity of ASCVD risk (p for trend < 0.05). Mean Na concentration in hair was significantly lower in the low-risk than in the other risk groups. By contrast, Co, U, and Hg concentrations showed significant negative associations with risk severity. Further studies are needed to assess whether dietary modification for trace elements could lower the risk of ASCVD.
Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies
Authors: Heitmar Rebekka , Brown James , Kyrou Ioannis
Published: March 2019

Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.
Associations of Probiotic Fermented Milk (PFM) and Yogurt Consumption with Bifidobacterium and Lactobacillus Components of the Gut Microbiota in Healthy Adults
Authors: Redondo-Useros Noemí , Gheorghe Alina , Díaz-Prieto Ligia E. , Villavisencio Brenda , Marcos Ascensión , Nova Esther
Published: March 2019

The current study investigates whether probiotic fermented milk (PFM) and yogurt consumption (YC) are related to both the ingested bacteria taxa and the overall gut microbiota (GM) composition in healthy adults. PFM and YC habits were analyzed in 260 subjects (51% male) by specific questionnaires, and the following groups were considered: (1) PFM groups: nonconsumers (PFM-NC, n = 175) and consumers (PFM, n = 85), divided as follows: Bifidobacterium-containing PFM (Bif-PFM; n = 33), Lactobacillus-containing PFM (Lb-PFM; n = 14), and mixed Bifidobacterium and Lactobacillus-containing PFM (Mixed-PFM; n = 38); (2) PFM-NC were classified as: yogurt nonconsumers (Y-NC; n = 40) and yogurt consumers (n = 135). GM was analyzed through 16S rRNA sequencing. PFM consumers showed higher Bifidobacteria taxa levels compared to NC, from phylum through to species. Specifically, Bif-PFM consumption was related to higher B. animalis levels (p < 0.001), whereas Lb-PFM consumption was associated to higher levels of Bifidobacterium (p < 0.045) and B. longum (p = 0.011). YC was related to higher levels of the yogurt starter Streptococcus thermophilus (p < 0.001). Lactobacilli and the overall GM were not related either to YC or PFM consumption. According to these results, healthy adults might benefit from PFM intake by increasing Bifidobacterium levels.
Metabolic Abnormalities in Normal Weight Children Are Associated with Increased Visceral Fat Accumulation, Elevated Plasma Endotoxin Levels and a Higher Monosaccharide Intake
Authors: Nier Anika , Brandt Annette , Baumann Anja , Conzelmann Ina Barbara , Özel Yelda , Bergheim Ina
Published: March 2019

Being overweight has been identified as the main risk factor for the development of metabolic disorders in adults and children. However, recent studies suggest that normal weight individuals are also frequently affected by metabolic abnormalities with underlying mechanisms not yet fully understood. The aim of the present study was to determine if dietary pattern and markers of intestinal permeability, as well as inflammation, differ between normal weight healthy children and normal weight children suffering from metabolic abnormalities. In total, 45 normal weight children aged 5–9 years were included in the study, of whom nine suffered from metabolic abnormalities. Anthropometric data, dietary intake and markers of inflammation, as well as intestinal permeability, were assessed in fasting blood samples. Neither BMI nor BMI-SDS differed between groups; however, children with metabolic abnormalities had a significantly larger waist circumference (+~5 cm) and a higher leptin to adiponectin ratio. While plasma leptin levels are significantly higher in normal weight children with metabolic abnormalities, neither TNF α nor sCD14, adiponectin, PAI-1 or IL-6 plasma levels differed between groups. Despite similar total calorie and macronutrient intake between groups, mean total fructose and total glucose intake (resulting mainly from sugar sweetened beverages, fruits and sweets) were higher in children with metabolic abnormalities than in healthy children. Time spent physically active was significantly higher in healthy normal weight children whereas time spent physically inactive was similar between groups. Furthermore, bacterial endotoxin levels were significantly higher in the peripheral plasma of normal weight children with metabolic abnormalities than in healthy normal weight children. Our results suggest that metabolic disorders in normal weight children are associated with a high monosaccharide intake and elevated bacterial endotoxin as well as leptin plasma levels, the latter also discussed as being indicative of visceral adiposity.
Consumers’ Perceptions of Coffee Health Benefits and Motives for Coffee Consumption and Purchasing
Authors: Samoggia Antonella , Riedel Bettina
Published: March 2019

Coffee is popular worldwide and consumption is increasing, particularly in non-traditional markets. There is evidence that coffee consumption may have beneficial health effects. Consumers’ beliefs in the health benefits of coffee are unclear. The study aimed at analyzing consumers’ perceptions of coffee health benefits, consumption and purchasing motives of coffee consumers with positive perceptions of coffee health benefits, and willingness to pay for coffee with associated health claims. Data were collected through a face-to-face survey with consumers, resulting in a convenience sample of 250 questionnaires valid for data elaboration. Results were elaborated with factor analysis and logistic regression analysis. Findings revealed that a relevant minority of consumers believed that coffee could have positive health effects. The consumer with a positive perception of coffee health benefits is mostly male, young, works, is familiar with non-espresso-based coffee, consumes a limited amount of coffee (generally not for breakfast and often in social settings), and buys coffee at retail outlets. Consumers drink coffee for its energetic and therapeutic effects. Coffee consumption is still price-driven, but consumers are interested in purchasing coffee with associated health claims. There is the opportunity to improve the perception of coffee health benefits in consumers’ minds.
Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
Authors: Kim Seog-Young , Lee Mak-Soon , Chang Eugene , Jung Sunyoon , Ko Hyunmi , Lee Eunyoung , Lee Soojin , Kim Chong-Tai , Kim In-Hwan , Kim Yangha
Published: March 2019

Obesity is intimately related to a chronic inflammatory state, with augmentation of macrophage infiltration and pro-inflammatory cytokine secretion in white adipose tissue (WAT) and mitochondrial dysfunction in skeletal muscle. The specific aim of this study is to evaluate effects of tartary buckwheat extract (TB) on obesity-induced adipose tissue inflammation and muscle peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α/sirtulin 1 (SIRT1) pathway in rats fed a high-fat diet. Sprague-Dawley rats were divided into four groups and fed either a normal diet (NOR), 45% high-fat diet (HF), HF + low dose of TB (TB-L; 5 g/kg diet), or HF + high dose of TB (TB-H; 10 g/kg diet) for 13 weeks. TB significantly reduced adipose tissue mass with decreased adipogenic gene expression of PPAR-γ and aP2. Serum nitric oxide levels and adipose tissue macrophage M1 polarization gene markers, such as iNOS, CD11c, and Arg1, and pro-inflammatory gene expression, including TNF-α, IL-6, and MCP-1, were remarkably downregulated in the TB-L and TB-H groups. Moreover, TB supplementation increased gene expression of PGC-1α and SIRT1, involved in muscle biogenesis and function. These results suggested that TB might attenuate obesity-induced inflammation and mitochondrial dysfunction by modulating adipose tissue inflammation and the muscle PGC-1α/SIRT1 pathway.
Intra-Species and Inter-Species Differences in Cytokine Production by Porcine Antigen-Presenting Cells Stimulated by Mycoplasma hyopneumoniae, M. hyorhinis, and M. flocculare
Authors: Fourour Sarah , Marois-Créhan Corinne , Martelet Léa , Fablet Christelle , Kempf Isabelle , Gottschalk Marcelo , Segura Mariela
Published: March 2019

Mycoplasma hyorhinis and M. flocculare are commonly co-isolated with M. hyopneumoniae (primary agent of swine enzootic pneumonia) in gross pneumonia-like lesions, but their involvement in the disease process remains unknown. T cells play an immuno-pathological role during mycoplasmal infections. Dendritic cells (DCs) are major antigen-presenting cells involved in T cell activation and differentiation. In this study, we investigated cytokine (IL-6, IL-8, IL-10, IL-12, and TNF-α) production by porcine bone-marrow-derived DCs (BM-DCs) stimulated by M. hyopneumoniae, M. hyorhinis, and/or M. flocculare. Results showed that cytokine production levels were relatively homogenous for all evaluated M. hyopneumoniae strains in contrast to M. hyorhinis and M. flocculare strains. The most noteworthy inter-species differences were the overall (i) lower IL-12 production capacity of M. hyopneumoniae, and (ii) higher TNF-α production capacity of M. flocculare. Co-stimulation of BM-DCs showed that M. hyorhinis dominated the IL-12 production independently of its association with M. hyopneumoniae or M. flocculare. In addition, a decreased BM-DC production of TNF-α was generally observed in the presence of mycoplasma associations. Lastly, M. flocculare association with M. hyopneumoniae increased BM-DC ability to secrete IL-10. A higher cytotoxicity level in BM-DCs stimulated by M. hyorhinis was also observed. Overall, this study demonstrated that the combination of M. hyorhinis or M. flocculare with M. hyopneumoniae may participate to the modulation of the immune response that might affect the final disease outcome.
Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses
Authors: Bermejo Marival , Kuminek Gislaine , Al-Gousous Jozef , Ruiz-Picazo Alejandro , Tsume Yasuhiro , Garcia-Arieta Alfredo , González-Alvarez Isabel , Hens Bart , Mudie Deanna , Amidon Gregory E. , Rodriguez-Hornedo Nair , Amidon Gordon L.
Published: March 2019

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt—Using a combination of in vitro techniques and pharmacokinetic analysis. The non-bioequivalence (non-BE) tablet group achieved higher plasma Cmax and area under the curve (AUC) than the reference and BE tablets groups, with only one difference in tablet composition, which was the presence of calcium monohydrogen phosphate, an alkalinizing excipient, in the tablet core of the non-BE formulation. Concentration profiles determined using a gastrointestinal simulator (GIS) apparatus designed with 0.01 N hydrochloric acid and 34 mM sodium chloride as the gastric medium and fasted state simulated intestinal fluids (FaSSIF-v1) as the intestinal medium showed a faster rate and a higher extent of dissolution of the non-BE product compared to the BE and reference products. These in vitro profiles mirrored the fraction doses absorbed in vivo obtained from deconvoluted plasma concentration–time profiles. However, when sodium chloride was not included in the gastric medium and phosphate buffer without bile salts and phospholipids were used as the intestinal medium, the three products exhibited nearly identical concentration profiles. Microscopic examination of DKT salt dissolution in the gastric medium containing sodium chloride identified that when calcium phosphate was present, the DKT dissolved without conversion to the less soluble free acid, which was consistent with the higher drug exposure of the non-BE formulation. In the absence of calcium phosphate, however, dexketoprofen trometamol salt dissolution began with a nano-phase formation that grew to a liquid–liquid phase separation (LLPS) and formed the less soluble free acid crystals. This phenomenon was dependent on the salt/excipient concentrations and the presence of free acid crystals in the salt phase. This work demonstrated the importance of excipients and purity of salt phase on the evolution and rate of salt disproportionation pathways. Moreover, the presented data clearly showed the usefulness of the GIS apparatus as a discriminating tool that could highlight the differences in formulation behavior when utilizing physiologically-relevant media and experimental conditions in combination with microscopy imaging.
One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
Authors: Ding Jun , Chen Guilin , Chen Guofang , Guo Mingquan
Published: March 2019

Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag+ to Ag0. The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC50) against Hep G2 cells was 1.92 μg/mL, indicating a good antitumor property of the nanoparticle at low dosage.
Environmental Factors Influence Plant Vascular System and Water Regulation
Authors: Qaderi Mirwais M. , Martel Ashley B. , Dixon Sage L.
Published: March 2019

Developmental initiation of plant vascular tissue, including xylem and phloem, from the vascular cambium depends on environmental factors, such as temperature and precipitation. Proper formation of vascular tissue is critical for the transpiration stream, along with photosynthesis as a whole. While effects of individual environmental factors on the transpiration stream are well studied, interactive effects of multiple stress factors are underrepresented. As expected, climate change will result in plants experiencing multiple co-occurring environmental stress factors, which require further studies. Also, the effects of the main climate change components (carbon dioxide, temperature, and drought) on vascular cambium are not well understood. This review aims at synthesizing current knowledge regarding the effects of the main climate change components on the initiation and differentiation of vascular cambium, the transpiration stream, and photosynthesis. We predict that combined environmental factors will result in increased diameter and density of xylem vessels or tracheids in the absence of water stress. However, drought may decrease the density of xylem vessels or tracheids. All interactive combinations are expected to increase vascular cell wall thickness, and therefore increase carbon allocation to these tissues. A comprehensive study of the effects of multiple environmental factors on plant vascular tissue and water regulation should help us understand plant responses to climate change.
Synthetic Routes to Silsesquioxane-Based Systems as Photoactive Materials and Their Precursors
Authors: Dudziec Beata , Żak Patrycja , Marciniec Bogdan
Published: March 2019

Over the past two decades, organic optoelectronic materials have been considered very promising. The attractiveness of this group of compounds, regardless of their undisputable application potential, lies in the possibility of their use in the construction of organic–inorganic hybrid materials. This class of frameworks also considers nanostructural polyhedral oligomeric silsesquioxanes (POSSs) with “organic coronae” and precisely defined organic architectures between dispersed rigid silica cores. A significant number of papers on the design and development of POSS-based organic optoelectronic as well as photoluminescent (PL) materials have been published recently. In view of the scientific literature abounding with numerous examples of their application (i.e., as OLEDs), the aim of this review is to present efficient synthetic pathways leading to the formation of nanocomposite materials based on silsesquioxane systems that contain organic chromophores of complex nature. A summary of stoichiometric and predominantly catalytic methods for these silsesquioxane-based systems to be applied in the construction of photoactive materials or their precursors is given.
Transcrystallization of Isotactic Polypropylene/Bacterial Cellulose Hamburger Composite
Authors: Wang Bo , Lin Fu-hua , Li Xiang-yang , Ji Xu-ran , Liu Si-xiao , Han Xiao-jing , Yuan Zheng-qiu , Luo Jun
Published: March 2019

Isotactic polypropylene (iPP) is a commonly used thermoplastic polymer with many excellent properties. But high brittleness, especially at low temperatures, limits the use of iPP. The presence of transcrystallization of iPP makes it possible for fiber-reinforced iPP composites with higher strength. Bacterial cellulose (BC) is a kind of cellulose with great potential to be used as a new filler to reinforce iPP due to its high crystallinity, biodegradability and efficient mechanical properties. In this study, the iPP/BC hamburger composite was prepared by a simple hot press and maleic anhydride grafted polypropylene (MAPP) was used to improve the interface compatibility of iPP and BC. The polarizing microscope (POM) photograph shows that BC successfully induces the transcrystallization of iPP. The differential Scanning Calorimeter (DSC) date proves that the addition of BC could improve the thermal properties and crystallization rate of the composite. Especially, this change is more obvious of the iPP/MAPP/BC. The mechanical properties of the iPP/BC composites were greatly increased. This DSC date is higher than BC; we used BC particles to enhance the iPP in our previous research. The scanning Electron Microscope (SEM) analysis intuitively shows that the interface of the iPP/MAPP/BC is more smooth and flat than the iPP/BC. The fourier Transform infrared spectroscopy (FT-IR) analysis of the iPP/BC hamburger composites was shown that a new C=O group vibration appeared at 1743 cm−1, which indicated that the hydrogen bond structure of BC molecules was weakened and some hydroxyl groups were substituted after modification which can increase the lipophilicity of BC. These results indicated that the BC fiber can easily induce the transcrystallization of iPP, which has excellent mechanical properties. Moreover, the addition of MAPP contributes greatly to the interface compatibility of iPP and BC.
Construction of Efficient Platform Escherichia coli Strains for Polyhydroxyalkanoate Production by Engineering Branched Pathway
Authors: Jung Hye-Rim , Yang Su-Yeon , Moon Yu-Mi , Choi Tae-Rim , Song Hun-Suk , Bhatia Shashi Kant , Gurav Ranjit , Kim Eun-Jung , Kim Byung-Gee , Yang Yung-Hun
Published: March 2019

Polyhydroxyalkanoate (PHA) is a potential substitute for petroleum-based plastics and can be produced by many microorganisms, including recombinant Escherichia coli. For efficient conversion of substrates and maximum PHA production, we performed multiple engineering of branched pathways in E. coli. We deleted four genes (pflb, ldhA, adhE, and fnr), which contributed to the formation of byproducts, using the CRISPR/Cas9 system and overexpressed pntAB, which catalyzes the interconversion of NADH and NADPH. The constructed strain, HR002, showed accumulation of acetyl-CoA and decreased levels of byproducts, resulting in dramatic increases in cell growth and PHA content. Thus, we demonstrated the effects of multiple engineering for redirecting carbon flux into PHA production without any concerns regarding simultaneous deletion.
Implementation of Maximum Power Point Tracking Based on Variable Speed Forecasting for Wind Energy Systems
Authors: Zhang Yujia , Zhang Lei , Liu Yongwen
Published: March 2019

In order to precisely control the wind power generation systems under nonlinear variable wind velocity, this paper proposes a novel maximum power tracking (MPPT) strategy for wind turbine systems based on a hybrid wind velocity forecasting algorithm. The proposed algorithm adapts the bat algorithm and improved extreme learning machine (BA-ELM) for forecasting wind speed to alleviate the slow response of anemometers and sensors, considering that the change of wind speed requires a very short response time. In the controlling strategy, to optimize the output power, a state feedback control technique is proposed to achieve the rotor flux and rotor speed tracking purpose based on MPPT algorithm. This method could decouple the current and voltage of induction generator to track the reference of stator current and flux linkage. By adjusting the wind turbine mechanical speed, the wind energy system could operate at the optimal rotational speed and achieve the maximal power. Simulation results verified the effectiveness of the proposed technique.
Application of VES Acid System on Carbonate Rocks with Uninvaded Matrix for Acid Etching and Fracture Propagation
Authors: Wu Yahong , Luo Weiwei , Jia Xunan , Fang Haoqing , Wang Honggang , Yu Shuai
Published: March 2019

We investigated the performance of viscoelastic surfactant (VES) solution when applied in treatment on the uninvaded matrix using core flooding tests to analyze the impact of VES/CaCl2 concentration on fluid viscosity. In this paper, core samples from Tahe carbonate reservoir, with an average permeability less than 0.02 × 10−3 μm−2 and a small average porosity in the range of approximately 0.04–5.24% are used in the experiments. Computed tomography (CT) scanning is used to provide a detailed description of inner structure variation of cores after the acid system treatment. The results confirmed that a large pressure difference contributed to fracture propagation and the relative permeability of water increased significantly after the treatment. It was also found that higher concentrations of VES and/or Ca2+ induced higher viscosity and a stronger fracturing effect, while a lower concentration improved the reaction rates and etching effect, generating small worm holes inside the core. Foam in-situ produced during the etching process is the major contributor to the fluid viscosity enhancement. The permeability of fracture formed on the surface of the core is more sensitive to the confining pressure. These findings can help better understand the rheological properties of the acid system and etching and fracturing mechanisms during acid treatment, and which provides instructions for field implementation.
Evaluating the Factors that are Affecting the Implementation of Industry 4.0 Technologies in Manufacturing MSMEs, the Case of Peru
Authors: Huang Chung-Jen , Talla Chicoma Elisa Denisse , Huang Yi-Hsien
Published: March 2019

The micro, small, and medium enterprises (MSMEs) sector plays a very crucial role in the economic and social development of Peru. Unfortunately, the tough access to the use of technologies is one of the weaknesses of this type of enterprises, which implies a low technological intensity production, according to the new technological trends. This study analyzes the factors that are affecting the implementation of Industry 4.0 technologies in Peruvian micro, small, and medium enterprises. According to the findings from the semi-structured interviews, it has identified four factors that respond to the main question of this research—lack of advanced technology, lack of financial investment, poor management vision, and lack of skilled workers. Data from 49 enterprises from the manufacturing sector were used for the assessment. The surveys conducted on business managers were evaluated using a multi-criterion decision-making method by the analytic hierarchy process. The findings of the study generate some recommendations that could be beneficial for the sectors involved with micro, small, and medium enterprises in Peru.
Je Suis Charlie or the Fragility of the Republican Sacred: On January 11th, 2015 and Its Afterlives
Authors: Mukherjee S. Romi
Published: March 2019

Following the Charlie Hebdo attacks, the demonstrations or “public mourning” of January 11th, 2015 were heralded by many as the return of the republican sacred, the re-crystallization of a long dormant people, and the resurrection of French fraternity en vivo. However, in the saturation of these political hagiographies, a series of trenchant critiques and observations quickly sought to deconstruct the meaning and putative symbolic power of January 11th. One was struck by the homogeneity of “the people” and the ostensible absence of Arabo-Muslim voices in the somber effervescence that typified the post-Charlie ambiance. Moments of silence were mocked in the banlieue and the homage rendered to the “blasphemers” was blasphemed itself. The imperative to “be Charlie” emerged less as a totemic index of republican solidarity than a Manichean strategy which exacerbated the generally perceived “fracture française”. The result was not only a calling into question of the legitimacy of January 11th, but also a series of counter-articulations which affirmed inter alia “Je ne suis pas Charlie” or worse “Je suis Coulibaly”. January 11th also divided the French left between those who read the event as the re-enchantment of the republican sacred and the people and “liberal” missives which deemed it a simulacra of solidarity, a racist demonstration comprised of “Catholic Zombies” and “Islamophobes”. This paper examines the cleavages engendered by January 11th and its afterlives which reveal not only the fragility of the Republic as a project, but also the fragility of the political sacred that has historically girded this project. At stake is not simply the question “who is Charlie”, but rather “who are the people” and what form they can or should take in a pluralist republic plunged in the perilous entre-deux between communitarianism and the possibility of a cosmopolitan republicanism. January 11th, far from being a simple demonstration, is a metaphor, a nodal point, and a seismograph of the force and frailness of the republican sacred and its capacity to enthrall, convince, and console.
Keeping It Real: Decolonizing Christian Inter-Religious Practice as an Exercise in a Practical Theology of the Cross
Authors: McCarroll Pamela R.
Published: March 2019

“What is suffering? What is hope?” These are questions I have asked for years with classes full of students training for Christian ministry. Now, I ask these questions in classes with Buddhist, Muslim, Jewish, Christian, and ‘spiritual but not religious’ students, all in training to be spiritual care therapists. The institution where I serve is in the process of transitioning from a mono-religious Christian theological College to a centre for multi/inter-religious education. Those of us who teach in the program are disrupted continually by pedagogical challenges that both perplex and energize us. The multi-religious classroom decolonizes spaces long dominated by Christian theological discourse. Course content yields to a fluid and open-ended, interactive process. My “mastery of the field” gives way to an ongoing practice of surrender—a kenotic self-emptying—that usually leaves me shaken in overwhelming awe or angst-ridden questioning. Through a practical theological methodology that begins with lived human experience, this paper shares an autoethnographic account of my experience as a teacher in the multi-religious classroom. It presents key dimensions of the theology of the cross as an interpretive framework and closes by examining how the theology of the cross offers a practical Christian theological reflective process to empower decolonizing pedagogy.
The Bridging Activity of Multiracial Congregations
Authors: Polson Edward C. , Gillespie Rachel
Published: March 2019

The growing diversity of U.S. communities has led scholars to explore how racial/ethnic diversity effects social capital, civic engagement, and social trust. Less is known about the relationship between diversity and the work of community-based organizations (CBOs). In this study, we examine how the racial/ethnic composition of one ubiquitous type of CBO, religious congregations, is related to measures of organizational bridging social capital. Analyzing data collected through a census of congregations in one Midwestern county, we explore the relationship between racial/ethnic diversity and the bridging activity of religious congregations. We find that multiracial congregations are more likely to be involved with externally focused service programs, tend to support a larger number of programs, and report more interorganizational collaborators than other congregations. Our findings suggest that multiracial congregations can provide a valuable resource for increasingly diverse communities and civil society.
“He Who Sees Does Not Desire to Imagine”: The Shifting Role of Art and Aesthetic Observation in Medieval Franciscan Theological Discourse in the Fourteenth Century
Authors: Bychkov Oleg
Published: March 2019

In the thirteenth century, following Neoplatonic and Patristic trends, art and aesthetic experience were still treated as symbolic, as “vestiges” or “echoes” of the divine that lead us to it. However, in the early fourteenth century, attitudes to concrete sensory/aesthetic experience begin to shift and theologians adopted the model of concrete phenomenal observation of sensory experience. Concrete sensory-aesthetic experience is endowed with a much higher value: seeing something is not the same as imagining it, recalling it, or thinking about it. This new approach results in some heterodox views about our phenomenal experience and debates about the exact status of “intentional” (phenomenal) appearance. These debates lead to profound observations about the nature of aesthetic-sensory experience of art objects and a re-evaluation of the status of the artistic image, which is now seen as much more than the platonic “copy of a copy”. In other words, starting with the fourteenth century, theologians start to pay attention to concrete aesthetic (sensory) experience and use their observations to make conclusions about various cognitive and perceptual issues that could be relevant to a discussion of the divine. That is, quite separately from theoretical theological observations, art and aesthetic experience now provide independent approaches to the divine or spiritual via the experience of aesthetic wonder as a starting point. It is now our concrete experience of sensory and aesthetic objects that starts the train of thought, at times leading to some unorthodox conclusions that contradict the doctrine (such as the skeptical point of view). The intellectual shift in treating sensory and artistic objects in the fourteenth century invites some parallels with the current discussions of the experience of aesthetic wonder in “post-secular” thought.
Design Principles of Early Stone Pagodas in Ancient Korean Architecture: Case Studies on the Stone Pagodas at Chŏngnimsa and Kamŭnsa Buddhist Temples
Authors: Cha Juhwan , Kim Young Jae
Published: March 2019

Ancient books on East Asian mathematics introduced to the Korean Peninsula enrich our understanding of the arithmetic notions that mold the creative thought processes of the ancients. They believed that all objects in the universe could be composed of circles and squares and all items could be expressed in terms of geometrical profiles. Through the combination of circles and squares, the ancient East Asians expressed the order of the world and unraveled it mathematically. These principles are evident in the construction principles of early Korean stone pagodas. In particular, the square root of 2 (√2) is a very important number in the delineation represented in the consolidation of inscribed and circumscribed circles with squares. Further, the square root of 2 is applied as a design principle in the construction of the stone pagodas at the temples Chŏngnimsa and Kamŭnsa. This article demonstrates that the ancients on the continuous impact of the Jiuzhang Suanshu and the Zhoubi Suanshu constructed the pagodas complying with design principles based on the arithmetic and geometric proportional systems of √2 times, which are intended to adjust compositional proportions and the gradual decrease in length to shape the tripartite partition of the foundation, the pagoda body, and the finial in stone pagodas.
Sustainable Production and Consumption of Paper and Paper Products in Nigeria: A Review
Authors: Ezeudu Obiora B. , Agunwamba Jonah C. , Ezeasor Ikenna C. , Madu Christian N.
Published: March 2019

Paper as a consumer product offers a undisputed benefits to human society, and it has been proven to be critical in driving most sensitive needs of mankind—principally in areas of security, education, sanitation, and communication—and thus has been produced and consumed worldwide. Its sustainable production and usage is one topic that has featured prominently in many discussion fronts and more often than not ends with recommendations for an alternative source of raw material, improvement in production procedures, and ecological concerns. Paper use is an ecological concern that has triggered many paper intervention actions around the world such as the Paper Task Force in USA, Sustainable Paper Alliance in China, and Paper and Beyond in Europe. In Nigeria, however, challenges associated with paper production, consumption, and economic prospects have not been adequately tackled. This is conspicuously evident in the huge volume of paper products imported annually into the country as a result of unsustainable local production. The cumulative impact of these issues reflect negatively on the Nigeria’s paper industry and spread indirectly to the entire country’s economy in terms of high capital freight spent on importation, volatile product price, and loss of employment opportunities. This work sought to review the challenges and opportunities associated with raw material sources, energy and water consumption, environmental pollution, paper consumption, and disposal of used paper products in Nigeria. The current review also advocated for wastepaper as a variant of raw material with a sustainable potential.
A Deep Learning Integrated Lee–Carter Model
Authors: Nigri Andrea , Levantesi Susanna , Marino Mario , Scognamiglio Salvatore , Perla Francesca
Published: March 2019

In the field of mortality, the Lee–Carter based approach can be considered the milestone to forecast mortality rates among stochastic models. We could define a “Lee–Carter model family” that embraces all developments of this model, including its first formulation (1992) that remains the benchmark for comparing the performance of future models. In the Lee–Carter model, the κ t parameter, describing the mortality trend over time, plays an important role about the future mortality behavior. The traditional ARIMA process usually used to model κ t shows evident limitations to describe the future mortality shape. Concerning forecasting phase, academics should approach a more plausible way in order to think a nonlinear shape of the projected mortality rates. Therefore, we propose an alternative approach the ARIMA processes based on a deep learning technique. More precisely, in order to catch the pattern of κ t series over time more accurately, we apply a Recurrent Neural Network with a Long Short-Term Memory architecture and integrate the Lee–Carter model to improve its predictive capacity. The proposed approach provides significant performance in terms of predictive accuracy and also allow for avoiding the time-chunks’ a priori selection. Indeed, it is a common practice among academics to delete the time in which the noise is overflowing or the data quality is insufficient. The strength of the Long Short-Term Memory network lies in its ability to treat this noise and adequately reproduce it into the forecasted trend, due to its own architecture enabling to take into account significant long-term patterns.
Detection and Monitoring of Tunneling Induced Ground Movements Using Sentinel-1 SAR Interferometry
Authors: Roccheggiani Matteo , Piacentini Daniela , Tirincanti Emanuela , Perissin Daniele , Menichetti Marco
Published: March 2019

SAR interferometry is a powerful tool to obtain millimeter accuracy measurements of surface displacements. The Sentinel-1 satellite mission nowadays provides extensive spatial coverage, regular acquisitions and open availability. In this paper, we present an MT-InSAR analysis showing the spatial and temporal evolution of ground displacements arising from the construction of a 3.71 km overflow tunnel in Genoa, Italy. Underground tunneling can often modify the hydrological regime around an excavated area and might induce generalized surface subsidence phenomena due to pore pressure variations, especially under buildings. The tunnel was excavated beneath a densely urbanized area lying on upper Cretaceous marly limestone and Pliocene clays. Significant cumulative displacements up to 30 mm in the Line of Sight (LOS) direction were detected during the tunnel excavation. No displacements were recorded before until the middle of 2016. The Persistent Scatterers Interferometry (PSI) analysis reveals in high detail the areal subsidence, especially where the subsurface is characterized by clay and alluvial deposits as well as there is the presence of large building complexes. The time-series and the displacement rate cross-sections highlight a clear relation with the tunnel face advancement, responsible for the subsidence phenomena, which proceeded northward starting from the middle of 2016 to the end of 2017. The stabilization occurred in a range of five-six months from the beginning of each displacement phase. Due to the low subsidence ratio the ground settlements did not cause severe damages to the buildings.