bluuebunny/crossref_metadata_2025 huggingface dataset:
The 5-HTTLPR genotype, early life adversity and cortisol responsivity to psychosocial stress in women
Authors: Aleknaviciute Jurate , Tulen Joke H. M. , de Rijke Yolanda B. , van der Kroeg Mark , Kooiman Cornelis G. , Kushner Steven A.
Published: June 2018

Background

The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has previously been associated with hypothalamus–pituitary–adrenal axis function. Moreover, it has been suggested that this association is moderated by an interaction with stressful life experiences.

Aims

To investigate the moderation of cortisol response to psychosocial stress by 5-HTTLPR genotype, either directly or through an interaction with early life stress.

Method

A total of 151 women, 85 of which had personality psychopathology, performed the Trier Social Stress Test while cortisol responsivity was assessed.

Results

The results demonstrate a main effect of genotype on cortisol responsivity. Women carrying two copies of the long version of 5-HTTLPR exhibited stronger cortisol responses to psychosocial stress than women with at least one copy of the short allele (P = 0.03). However, the proportion of the variance of stress-induced cortisol responsivity explained by 5-HTTLPR genotype was not further strengthened by including early life adversity as a moderating factor (P = 0.52).

Conclusions

Our results highlight the need to clarify gender-specific biological factors influencing the serotonergic system. Furthermore, our results suggest that childhood maltreatment, specifically during the first 15 years of life, is unlikely to exert a moderating influence of large effect on the relationship between the 5-HTTLPR genotype and cortisol responsivity to psychosocial stress.

Declaration of interest

None.
Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions
Authors: Bangash M.A. , Alles Sascha R.A. , Santana-Varela Sonia , Millet Queensta , Sikandar Shafaq , de Clauser Larissa , ter Heegde Freija , Habib Abdella M. , Pereira Vanessa , Sexton Jane E. , Emery Edward C. , Li Shengnan , Luiz Ana P. , Erdos Janka , Gossage Samuel J. , Zhao Jing , Cox James J. , Wood John N.
Published: June 2018

Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression using microarrays in mouse models related to human chronic pain.

Methods: Six different pain models were studied in male C57BL/6J mice: (1) bone cancer pain using cancer cell injection in the intramedullary space of the femur; (2) neuropathic pain using partial sciatic nerve ligation; (3) osteoarthritis pain using mechanical joint loading; (4) chemotherapy-induced pain with oxaliplatin; (5) chronic muscle pain using hyperalgesic priming; and (6) inflammatory pain using intraplantar complete Freund’s adjuvant. Microarray analyses were performed using RNA isolated from dorsal root ganglia and compared to sham/vehicle treated controls.

Results: Differentially expressed genes (DEGs) were identified. Known and previously unreported genes were found to be dysregulated in each pain model. The transcriptomic profiles for each model were compared and expression profiles of DEGs within subsets of DRG neuronal populations were analysed to determine whether specific neuronal subsets could be linked to each of the pain models. 

Conclusions: Each pain model exhibits a unique set of altered transcripts implying distinct cellular responses to different painful stimuli. No simple direct link between genetically distinct sets of neurons and particular pain models could be discerned.
Geographical distribution of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) and genetic diversity of invading population of Ae. albopictus in the Republic of the Congo
Authors: Kamgang Basile , Wilson-Bahun Theodel A. , Irving Helen , Kusimo Michael O. , Lenga Arsene , Wondji Charles S.
Published: June 2018

Background:The arbovirus vector,Aedes albopictus,originating from Asia, has recently invaded African countries, including the Republic of the Congo, where it was associated with a chikungunya outbreak. Up until now, little was known about its distribution in relation to the nativeAedes aegyptiand how the invasion will modify the epidemiology of arboviral diseases. Here, we assessed the current distribution ofAe. albopictusandAe. aegyptiin the Republic of the Congo and explored the genetic diversity of the invading species,Ae. albopictus.

Methods:Immature stages ofAedeswere collected in nine locations in the Republic of the Congo in 2017 following a north-south transect and reared to adult stage. Adults were morphologically identified, counted and grouped according to species and location. Genetic diversity ofAe. albopictuswas assessed by analyzing the cytochrome oxidase I (COI) gene.

Results:Ae.albopictusandAe. aegyptiwere found together across the country in all the locations investigated. The invasive species is predominant over the native species in all locations except Brazzaville, suggesting thatAe. albopictusis displacingAe. aegyptiacross Congo. When comparing the species distributions across the two largest cities, Brazzaville and Pointe Noire,Ae. albopictuswas more prevalent thanAe. aegyptiin the suburbs whereas the opposite situation was reported in the city centre. Mitochondrial DNA analysis revealed very low genetic diversity ofAe. albopictuswith only three haplotypes recorded across the country supporting the recent introduction of this species in the Republic of the Congo. Phylogenetic tree analysis revealed thatAe. albopictusfrom Congo originated from other tropical Asian countries such as China, likely as a result of increasing trade links.

Conclusion:These findings are important for the implementation of vector control strategies and can serve as a foundation for further research on these vectors in the country.
Cross-sectional study among medical students in Latvia: Differences of mental symptoms and somatic symptoms among Latvian and international students
Authors: Rueckert Kamiar-Kersten , Ancane Gunta
Published: June 2018

Introduction. This research aims to determine the prevalence of mental symptoms (depressive symptoms, anxiety and adjustment disorders) and somatic symptoms among medical students at Riga Stradins University in Latvia, as well as to display the differences between local and international medical students.

Methods. A cross-sectional study was conducted by means of onlinebased questionnaires among medical students in their 1st, 4th and 6th years studying in Riga, Latvia, during March 2017. The mental and somatic symptoms were screened with the PHQ-D Option C (PHQ-15, PHQ-9, GAD-7). Symptoms of adjustment disorder were obtained by the ADNM-6. Medical students were divided into three groups according to their answers of the PHQ-D: Group A: no symptom, group B: a single symptom, group C: multiple symptoms. A general questionnaire and a questionnaire regarding stressful life events over the past half-year were distributed additionally.

Results. 67 (40.1%) participants were Latvian students; 100 (59.9%) were international students. 23 (34.3%) Latvian students were in group A, 20 (29.9%) in group B, 24 (35.8%) in group C. 51 (51%) international students were in group A, 34 (34%) in group B, 14 (14%) in group C. Latvians displayed statisti cally significantly more health-related symptoms (0.003). 11 (11%) international students who reported a stressful life event over the last half-year were in group C. 21 (31.3%) of Latvian students who reported a stressful life event over the last half-year were in group C. 73 (43.7%) of all students had experienced stressful life events and displayed troubles adjusting to them. 65 (63.1%) students of the two groups with a stressful life found the event to have a great burden on them, 63 (61.2%) were wondering whether it could happen again, and 73 (70.9%) tried to suppress their feelings.

Conclusion. Medical students in Latvia have a high prevalence of healthrelated symptoms. Latvian medical students display more health-related symptoms and symptoms of adjustment disorder. Further research needs to be performed to investigate whether Latvians have a lower threshold for stressors or whether they are exposed to more stressors than international students. The high prevalence of symptoms of adjustment disorder may impact the prospective patient-doctor relationship and the treatment outcome.
Height and weight norms and somatotypic height-weight classification of Estonian schoolchildren aged 7–18 years
Authors: Kaarma Helje , Veldre Gudrun , Saluste Liidia , Lintsi Mart , Kasmel Jaan , Tiit Ene-Margit , Stamm Raini , Toomsalu Maie , Salm Erik , Käärik Ene , Arend Andres
Published: June 2018

Relying on regularities of Estonian schoolchildren’s body build, height and weight norms and a somatotypic height-weight classification were created for Estonian schoolchildren aged 7–18 years.
On preservation and development of Estonian as a research language in anthropology – the role of the Yearbooks of the Estonian Anthropometric Register (1998–2002) in it. Part II
Authors: Kasmel Jaan , Kasmel Tiiu
Published: June 2018

On 18 July 2018, the Centre for Physical Anthropology at the University of Tartu will mark its 25th anniversary. The specialists of different research areas from whole Estonia who had gathered around this Centre also considered it necessary to preserve and develop Estonian as a research language in anthropo logy. When cooperation was established with the Estonian Anthropometric Register (founded in 1995), it became possible to publish the Estonian-language Yearbook of the Estonian Anthropometric Register (YEAR), the first of which was published in 1998, i.e. 20 years ago.

The article will deal with the YEARs published in 1998–2002 – who were the authors who decided to publish their research papers on anthropology in in Estonian in this serial, how many of them there were, in which towns and institutions they worked?

The first part of the overview [6] briefly described the publications by researchers of anthropology originating in Estonia, starting with publications in Latin and finishing with English as the main present-day language of research. Table 1 provided a general characterisation of the five yearbooks and Table 2 the distribution of the published articles according to the number of authors.

Tables 3–7 in the second part of the overview present the distribution of articles over the years according to their first authors. Table 8 presents the distribution of articles between Tartu and Tallinn and the institutions and their subunits in these towns according to the first authors of the articles.
The link of diet and exercise habits of the inhabitants of Pärnu city with body mass index
Authors: Õun Kandela , Übner Monika
Published: June 2018

This article gives an overview of the health behaviour survey of the adult population of the city of Pärnu, which was conducted in 2016. The results of the survey were used for compiling of the city health profile. The funder was the Pärnu city government. The authors focused on the links between the body mass index, diet and physical activity. The survey was carried out among the residents of the city of Pärnu aged 16–64 years. The questionnaire was filled by 506 respondents. Such a large survey had not been carried out in the city of Pärnu previously. In 2011 and 2014 two studies involving whole Estonia were conducted, in which the percentage of the respondents from Pärnu was too small to make further conclusions.

The study results revealed that 65% of respondents ranked their health good or very good, and that was an improvement compared to the previous survey made five years ago. Breakfast was important for respondents, and 86% of them had it every morning or on most days. 49% of respondents were of normal weight by body mass index and 47% were overweight or obese, and these numbers showed a 20% change for better health compared to the previous study. From April to September, 45% of respondents rode a bicycle to work. In their free time, 60% did it for at least 15 minutes per day. Women walked to the workplace more often than men. Men were more overweight and ate more white bread than women. Underweight respondents ate an average of one slice of white bread per day, while others consumed it twice less on average. There was a significant but small correlation between age and BMI (r=0.31), respondents with vocational education had the highest average BMI. Obese persons and respondents with poor physical fitness were less active than normal-weight persons.
Medea and Argonautics: Medicine, pharmacy, toxicology
Authors: Shengelia Ramaz
Published: June 2018

According to mythical heritage, Medea, a daughter of the king of Colchis (Western Georgia, 13th century BC), famous for her beauty, was very wise and closely associated with plant lore, concoction of medicines, and medical activities. She knew various forms of remedies for internal and external use, respiratory, and so forth. In her therapeutic arsenal, there were medical remedies for a variety of uses: for treatment of various diseases, soporifics, poisons, ointments, miraculous and magical substances as well.

Medea prepared the poisons by using special processing of medical remedies – extraction, infusion/tincture, thermal, mechanical, or chemical exposure, or concentration. The principle, according to which the modern medicine is developing, is contraria contrariis curantur (CCC), or contraries are cured, or allopathic medicine. At present, the priority still belongs to CCC. This is the direction that modern medicine and pharmacy throughout the world are following today.

The way of effective realization of this principle is a strong chemical source. The stronger the source, the more effective the result. This thesis is based on two major ways of realization of the CCC principle – suppressing and compensating therapy where achieving an effect without a potent substance would not be possible.

Toxicology and pharmacy were formed in the Roman Empire at the beginning of our era and are associated with the King of Pontus, a descendant of Colchis – Mithridates VI Eupator. Such a notion as the medicine/drug appeared in the Roman period. The authors do not describe the plant, animal or mineral resources but the product – the characteristics of the drug.

Thus, Medea is not only considered a pioneer of cosmetics, hematology, surgery, toxicology, and other areas but also the founder of the way for effective implementation of the main principle of modern medicine and the donor of word root medicine. Afterwards, the term acquired a broader generalization and consequently become a synonym of medical art.
SPECIAL ASPECTS OF TRAINING MATHEMATICS IN THE UNIVERSITIES OF ECONOMICS
Authors: Ряйсянен Татьяна , Ryaysyanen Tatyana , Уленгова Татьяна , Ulengova Tatyana
Published: June 2018

The arlicle covers on the development of educational process and professional skills improvement. Mathematical concepts application used for solution of economical applied problems help build neccesary profeccional skills. Skills of dividing problem-solving into several steps are fully developing during the process of training. In addition students are to estimate the value and analyze the results
Evaluation of the Possibility of Approval of the Audit of the Consolidated Financial Statements
Authors: Резвых И. , Rezvyh I.
Published: June 2018

Th is article is devoted to the peculiarities of the audit of the consolidated fi nancial statements, as well as the consideration of the initial stage of the audit — the possibility of accepting the task for audit. Th e article discusses the audit procedures that need to be carried out, proposed forms of working documentation of the auditor to refl ect the results of the procedures.
Convergence Problems of the Cash Flows Statement Preparation Methods Under the Russian and International Financial Reporting Standards
Authors: Калачева Ольга , Kalacheva Olga , Смелова С. , Smelova S.
Published: June 2018

The problem of convergence of the disclosure order in accounting (financial) reporting of information on cash flows by Russian and international standards is disclosed in the article. The authors emphasize that the integration of the Russian Federation into the world community requires from Russian organizations the provision of fi nancial statements according IFRS. However, most Russian companies are legally required to provide both IFRS fi nancial statements and RAS financial statements. In this regard, the Cash Flow Statement, as one of the obligatory statement of companies, is represented in this article as a tool for eff ectively assessing the organization’s ability to attract and use cash in the economic life.
Fregean Description Theory in Proof-Theoretical Setting
Authors: Indrzejczak Andrzej
Published: June 2018

We present a proof-theoretical analysis of the theory of definite descriptions which emerges from Frege’s approach and was formally developed by Kalish and Montague. This theory of definite descriptions is based on the assumption that all descriptions are treated as genuine terms. In particular, a special object is chosen as a designatum for all descriptions which fail to designate a unique object. Kalish and Montague provided a semantical treatment of such theory as well as complete axiomatic and natural deduction formalization. In the paper we provide a sequent calculus formalization of this logic and prove cut elimination theorem in the constructive manner.
AMBIENTE VIRTUAL DE APRENDIZAGEM: ELEMENTOS E FERRAMENTAS QUE INFLUENCIAM A INTERAÇÃO ONLINE
Authors: Cavalcante de Oliveira Josefa Kelly
Published: June 2018

Este estudo tem como objetivo analisar as interações e interatividade no ambiente virtual de aprendizagem -AVA Moodle de uma disciplina do curso de Pedagogia - UAB da Universidade Federal de Alagoas, bem como identificar a concepção que alunado possui sobre a influência da interação no processo de ensino aprendizagem. Partindo do conceito que aprender envolve interação e participação de todos e que na EAD a mediação acontece por meio do AVA. A questão norteadora é a seguinte: O que motiva o aluno a interagir no AVA e quais as ferramentas e elementos disponíveis no AVA que influenciam a interação virtual? O estudo teórico tem como base Behar (2013), Illera (2010), Mattar (2011), Silva (2017) entre outros autores que serviram de fundamentação teórica/bibliográfica para este estudo. O percurso metodológico envolveu coleta de dados por meio de questionários aplicados a alunos do curso de Pedagogia EAD. Os resultados permitiram perceber que os alunos compreendem a interação como elemento importante para a construção colaborativa do conhecimento e que as principais ferramentas de interação é o email, fórum e os espaços de postagem de atividades que servem como meio para troca de conhecimentos.
ENSINAR E APRENDER COM AS TECNOLOGIAS DIGITAIS EM REDE: POSSIBILIDADES, DESAFIOS E TENSÕES
Authors: De Oliveira Julio Lucas
Published: June 2018

Este artigo é centralizado em discutir as dificuldades do corpo docente na utilização das Tecnologias da Informação e Comunicação (TICs) na prática pedagógica. O objetivo principal da pesquisa é identificar os problemas que causam a falta de preparo, de orientação, de investimento e, até, de interesse por parte dos educadores. A pesquisa traz à tona as questões do despreparo e das barreiras que os professores encontram na utilização das TICs e os receios que os mesmos têm em usá-las, além de buscar explicações para a baixa aplicação de recursos pelo governo, local onde serão realizadas as pesquisas que buscarão responder às questões aqui elencadas e soluções para o desafio de unir tecnologia e educação.
Hypnic headache: pathophysiology, differential diagnosis and management
Authors: Camilo Rita Teresa Silva
Published: June 2018

Headache is one of the commonest reasons for patients to see a GP and to consult a neurologist. Hypnic headache (HH) is a rare type of short-lasting primary headache. It is sometimes called ‘alarm clock headache’ or ‘clockwise headache’, as it tends to wake people up from sleep around the same time each night—from a couple of nights a week to every single night. It was first described by Neil Raskin, a US neurologist, in 1988, and the diagnostic criteria have been further refined in the updated version of the International Classification of Headache Disorders (ICHD-3ß). This article will discuss the pathophysiology of HH, its clinical features and presentation, expanding on differential diagnosis and management suggestions, with reference to a patient case report. The aim is to draw nursing attention to this rare but often debilitating headache condition.
Ataxia and coenzyme Q10: an overview
Authors: Mantle David , Hargreaves Iain P
Published: June 2018

This article focuses on the hereditary ataxias, resulting from defects in specific genes, which include the spinocerebellar ataxias (SCAs), Friedreich's ataxia, and ataxia resulting from coenzyme Q10 (CoQ10) deficiency. CoQ10 is a vitamin-like substance that plays a key role in the biochemical process within mitochondria, supplying all cells with the energy required for normal functioning; CoQ10 is also important as an antioxidant, protecting cells (and particularly mitochondria) from free radical-induced oxidative damage. Oxidative stress, mitochondrial dysfunction and cellular energy depletion have been implicated in the pathogenesis of the hereditary ataxias; this provides a rationale for dietary supplementation with CoQ10 in these disorders. The authors have therefore reviewed clinical evidence for the potential benefit of oral supplementation with CoQ10 in the hereditary ataxias. Some categories of hereditary ataxia patients have demonstrated remarkable clinical improvement following CoQ10 supplementation, especially when administered at an early stage of disease. In particular, a number of studies have demonstrated significant symptomatic benefit in patients with ataxia resulting from primary CoQ10 deficiency, following oral supplementation with CoQ10. Although there is no consensus as to the dosage of CoQ10 to be used in ataxia management, clinical studies have typically used dosages in the range 300 to 3000 mg/day. With regard to safety, CoQ10 is generally well tolerated, with no significant adverse effects reported in long-term use.
Factors influencing implementation of cognitive and behavioural screening in motor neurone disease
Authors: Hodgins Faith , Bell Steve , Abrahams Sharon
Published: June 2018

Changes in cognition and behaviour occur in approximately 50% of people with amyotrophic lateral sclerosis (ALS), the most common form of motor neurone disease (MND). The aim of this study was to explore current factors influencing the implementation of cognitive and behavioural screening in MND care in the UK. Semi-structured interviews with healthcare professionals working in a range of settings were conducted and data were analysed thematically. In most of the settings included, a pathway to screening and neuropsychological intervention had not yet been established. Factors identified as barriers included: limited number of staff trained to administer screen; limited time available during outpatient clinic hours; and limited or no links with neuropsychological services. Screening was implemented routinely in one setting where there was support from a clinical neuropsychologist working within the MDT. Support from neuropsychological services was suggested to be necessary for interpretation of screening results and advice on intervention.
Informed consent: how much information should we give patients?
Authors: Smith Angela
Published: June 2018

Gaining valid consent from patients is an area of law that has developed over time. It is acknowledged that for adult patients, provided they have capacity and consent is given without duress, then they can give or refuse permission to treatment. However, the third aspect of valid consent, i.e. that of how much information should be provided to patients prior to them consenting, is an area that has been subject to much debate in recent years. In this article, Angela Smith looks at how the law has changed in recent years, and the impact the case of Montgomery v Lanarkshire Health Board [2015] UKSC 11 has had for health-care professionals.
What is the DPO's remit?
Authors: Walton Beth
Published: June 2018

The introduction of General Data Protection Rules means that all schools must enlist the services of a data protection officer and work with them to ensure compliance.
Being taken for a ride
Authors: Hart Karen
Published: June 2018

Karen Hart tries out a new coach hire service and discovers how its reliable service is supporting schools with their days out, providing an enjoyable journey for everyone.
Barriers and Pathways to Providing Long‐Acting Reversible Contraceptives in Massachusetts Community Health Centers: A Qualitative Exploration
Authors: Janiak Elizabeth , Clark Jill , Bartz Deborah , Langer Ana , Gottlieb Barbara
Published: June 2018

CONTEXT

Structural barriers to the provision of long‐acting reversible contraceptive (LARC) methods at community health centers have been identified in quantitative research, but the processes and behaviors by which center staff respond to these barriers are poorly understood.

METHODS

Focus group discussions were conducted with clinical, support and administrative staff at three Massachusetts community health centers between April 2014 and January 2015. The centers were purposively selected to constitute a sample with diverse characteristics. Overall, 57 individuals participated in seven focus groups. Data were analyzed inductively using a modified grounded theory approach, and typical pathways to obtaining LARC methods were identified.

RESULTS

Community health center staff provided contradictory descriptions of their facilities’ protocols and practices. Patients’ pathways to obtaining LARC methods were idiosyncratic and clinician‐dependent, and resulted in patients’ waiting between one week and three months to receive their preferred method. Providers’ individual comfort with and perceived competence in contraceptive counseling often shaped patients’ pathways to care. Overall, staff did not consider same‐day insertion of LARC methods a feasible goal. Counseling protocols, insurance verification practices and logistical challenges in ordering and stocking devices were identified as major barriers to timely placement.

CONCLUSIONS

Efforts to improve LARC provision at community health centers should include the education of staff in how expeditious placement constitutes clinical best practice and the implementation of infrastructural changes to support staff in efficiently counseling patients, scheduling placements and procuring LARC devices regardless of patients’ insurance coverage.
Genome-Wide Analysis of Circulating Cell-Free DNA Copy Number Detects Active Melanoma and Predicts Survival
Authors: Silva Shobha , Danson Sarah , Teare Dawn , Taylor Fiona , Bradford James , McDonagh Andrew J G , Salawu Abdulazeez , Wells Greg , Burghel George J , Brock Ian , Connley Daniel , Cramp Helen , Hughes David , Tiffin Nick , Cox Angela
Published: June 2018

BACKGROUND

A substantial number of melanoma patients develop local or metastatic recurrence, and early detection of these is vital to maximise benefit from new therapies such as inhibitors of BRAF and MEK, or immune checkpoints. This study explored the use of novel DNA copy-number profiles in circulating cell-free DNA (cfDNA) as a potential biomarker of active disease and survival.

PATIENTS AND METHODS

Melanoma patients were recruited from oncology and dermatology clinics in Sheffield, UK, and cfDNA was isolated from stored blood plasma. Using low-coverage whole-genome sequencing, we created copy-number profiles from cfDNA from 83 melanoma patients, 44 of whom had active disease. We used scoring algorithms to summarize copy-number aberrations and investigated their utility in multivariable logistic and Cox regression analyses.

RESULTS

The copy-number aberration score (CNAS) was a good discriminator of active disease (odds ratio, 3.1; 95% CI, 1.5–6.2; P = 0.002), and CNAS above or below the 75th percentile remained a significant discriminator in multivariable analysis for active disease (P = 0.019, with area under ROC curve of 0.90). Additionally, mortality was higher in those with CNASs above the 75th percentile than in those with lower scores (HR, 3.4; 95% CI, 1.5–7.9; P = 0.005), adjusting for stage of disease, disease status (active or resected), BRAF status, and cfDNA concentration.

CONCLUSIONS

This study demonstrates the potential of a de novo approach utilizing copy-number profiling of cfDNA as a biomarker of active disease and survival in melanoma. Longitudinal analysis of copy-number profiles as an early marker of relapsed disease is warranted.
Praxis matemática: reflexiones sobre la cognición que la hace posible
Authors: Núñez Rafael
Published: June 2018

La matemática forma un cuerpo único de conocimiento. Entre otras cosas, es abstracta, exacta, eficaz, simbolizable y proporciona sorprendentes aplicaciones al mundo real. En el campo de la filosofía de la matemática el estudio de la práctica matemática ha devenido gradualmente una importante área de investigación. ¿Qué aspectos de la mente y el cuerpo humano hacen posible la particular práctica matemática? En este artículo, reviso brevemente algunas dimensiones cognitivas que juegan un papel crucial en la creación y consolidación de la matemática.
Putnam’s indispensability argument revisited, reassessed, revived
Authors: Bueno Otávio
Published: June 2018

Crucial to Hilary Putnam’s realism in the philosophy of mathematics is to maintain the objectivity of mathematics without the commitment to the existence of mathematical objects. Putnam’s indispensability argument was devised as part of this conception. In this paper, I reconstruct and reassess Putnam’s argument for the indispensability of mathematics, and distinguish it from the more familiar, Quinean version of the argument. Although I argue that Putnam’s approach ultimately fails, I develop an alternative way of implementing his form of realism about mathematics that, by using different resources than those Putnam invokes, avoids the difficulties faced by his view.
Influence of Auditing on Financial Performance of Secondary Schools: A Case Study of Goromonzi District; Zimbabwe
Authors: Zhuwau Charles , Shumba Milton
Published: June 2018

Auditing, an internal financial control with high adoption in private sector has of late received great attention of the community in Zimbabwe calling for its adoption in public institutions. This is due to poor Corporate Governance practises not only parastatals, but in public schools as misappropriation of school funds scandals rock the nation since 2008. With the wake of 2015 government schools audit exercise, the research seeks an explanation of the relationship between auditing and financial performance of Goromonzi district secondary schools. With the absence of theory to explain the relationship in Zimbabwean education sector, the research aimed to establish the frequency schools need to be audited. Quantitatively, primary data were collected using questionnaires and personal interviews directed to government appointed and parent-elected School Development Committees (SDC) members, respectively. Secondary data from existing literature complemented primary data. Chi-square tests were used to analyse data to establish relationships existing between diverse variables. Carried tests indeed validated the existence of positive positive relationship between education attained by SDC members and their comprehension of auditing. Similar results were observed between audit frequency and performance of schools measured by standards improvement. Finally the research recommended how auditing can be implemented in schools as well as various strategies which can be adopted to ensure positive financial performance of schools.
Semmelweis Ignác és az Orvosi Hetilap
Authors: Kiss László
Published: June 2018

Abstract:

Ignác Semmelweis did not publish his discovery in Vienna – i.e., that the puerperal fever may be prevented by careful washing of the hand in chlorine solution (asepsis) – for ten years. The Medical Weekly started its publications edited by Lajos Markusovszky in Pest in 1857. Semmelweis as a professor of theoretical and practical obstetrics at the University of Pest published a study about puerperal fever in the first volume, and Hungarian physicians became familiar with Semmelweis’ opinion from this medical journal. Semmelweis was not only an author of the Medical Weekly, but he also edited a supplement of the Medical Weekly entitled Gynaecology and Paediatry. The Medical Weekly published regular accounts of the work of the clinic written by lecturers of Semmelweis and articles describing the most interesting cases of the clinic. Orv Hetil. 2018; 159(26): 1065–1070.
Práticas de Sustentabilidade e Resource Based View – RBV: estudo na rede Senac de Santa Catarina
Authors: Bortoluzzi Citania Aparecida Pilatti , Sehnem Simone , Petry David Rodrigo , Carvalho Carlos Eduardo , Santos Junior Silvio
Published: June 2018

O presente estudo analisa a relação entre práticas sustentáveis, recursos organizacionais e desempenho na Rede SENAC Santa Catarina. Trata-se de uma pesquisa do tipo survey que foi respondida por 113 colaboradores das 26 unidades do SENAC Santa Catarina, com a finalidade de identificar o nível de conhecimento sobre os assuntos pertinentes a gestão da sustentabilidade, por meio de 140 questões, em sua maioria medida por escalas. Para apresentação e análise dos resultados, serviu-se da utilização de médias escalares e da análise multivariada com aplicação das técnicas de correlação e regressão facilitando assim, a condensação e compreensão dos dados. Os resultados da pesquisa mostram que existem ações relacionadas às práticas sustentáveis e que as Unidades do SENAC, buscam incorporar práticas sustentáveis no seu dia a dia. Dos resultados é possível inferir que o desempenho das unidades do SENAC Santa Catarina é função de vários fatores, entre as quais as dimensões Gestão Estratégica de Resultados e Recursos e Capacidades Inimitáveis, compostas por dez variáveis cada uma, são as mais relevantes para o desempenho da Rede SENAC, representando 55% da variância do desempenho das unidades do SENAC Santa Catarina.
Plano de Logística Sustentável – PLS: Um estudo comparativo em Universidades Federais da Região Metropolitana de São Paulo
Authors: Pereira Raquel Da Silva , Barbosa Gebel Eduardo Mendonça
Published: June 2018

Desde a Convenção Internacional Rio+20 (2012), o Brasil avançou em termos de desenvolvimento sustentável, publicando o Decreto Federal n° 7.746/2012, que determina a implementação de um Plano de Logística Sustentável (PLS) em órgãos públicos federais. Nesse contexto enquadram-se as Universidades Federais. Assim, nesta pesquisa objetivou-se analisar e comparar os PLS de Universidades Federais na Região Metropolitana de São Paulo (RMSP): da Universidade Federal do ABC (UFABC) e da Universidade Federal de São Paulo (UNIFESP), evidenciando semelhanças e diferenças entre eles. Utilizou-se, estudo de cunho qualitativo e exploratório, com pesquisa documental, consubstanciada por entrevistas com pessoasdiretamente envolvidas na elaboração dosrespectivosplanos. Os dados foram analisados sob a ótica da análise de conteúdo. Os resultados permitem concluir que, apesar de a base normativa ser única quanto ao direcionamento construtivo do PLS, os referidos Institutos de Ensino Superior - IES adotaram formas distintas na orientação, estruturação e composição de esforços para a consecução do referido Plano.
La escritura como téchne del cuerpo (acotaciones históricas y evolución)
Authors: Godínes Juan Carlos Valdés
Published: June 2018

El trabajo presentado es un ensayo que establece la relación entre las categorías tecnología-cuerpo-escritura y la forma en que los cambios en la tecnología (digital) transforman las relaciones entre ellas. El objetivo consiste en construir referentes teóricos que permitan a la pedagogía contemporánea plantear y explorar procesos educativos alternativos surgidos a partir de los usos de la tecnología digital. El método utilizado es principalmente el reflexivo-analítico que permite el establecimiento de relaciones entre las categorías para realizar construcciones y deconstrucciones de planteamientos pedagógicos tradicionales; el trabajo representa una propuesta de como realizar análisis deconstructivos de categorías pedagógicas tradicionales para comprender su surgimiento, evolución y posibilidades a partir de la diversidad de prácticas educativas con las tecnologías digitales.
O processo de apropriação das tecnologias digitais móveis: uma experiência na formação continuada do professor de matemática
Authors: Prado Maria Elisabette Brisola Brito , Dias Fátima Aparecida da Silva , Padilha Willian Rocha
Published: June 2018

Este artigo tem por objetivo compreender como um grupo de professores de matemática de uma escola pública pensa e se apropria das Tecnologias Digitais Móveis (TDM), mais especificamente do tablet durante o processo de formação continuada. A pesquisa de natureza qualitativa envolveu a participação de seis professores que atuam no Ensino Fundamental da rede pública. A análise dos dados enfatizou quatro momentos, o primeiro contato para saber o que pensam os professores sobre o uso pedagógico das TDM, a Oficina com o uso das TDM, a prática com os alunos e a reflexão sobre a prática vivenciada. Os resultados mostraram que o processo de apropriação tecnológica é particular, situado e se dá de forma contínua.  Portanto, é necessário propiciar a formação do professor tendo como foco a reconstrução do conhecimento profissional na perspectiva do TPACK.
Reflexões sobre o ensino híbrido: uso da sala de aula invertida em cenários inovadores com TV Digital e múltiplas tela
Authors: Beserra Vagner , Quaglio Alexandre Marcondes , Falandes Carolina Gois
Published: June 2018

Neste artigo, busca-se descrever o contemporâneo cultural e social a partir da problematização das novas tecnologias e sua integração aos processos de ensino-aprendizagem. É dada a ênfase às metodologias ativas e híbridas dos dias atuais, sobretudo a de sala de aula invertida, para discutir a necessidade de criação de cenários inovadores para o campo. Para o desenvolvimento deste manuscrito de caráter teórico-conceitual, optou-se pela realização de uma pesquisa bibliográfica. Ao fim da reflexão, observa-se como conceitos e práticas de ensino híbrido e de sala de aula invertida alinham-se diretamente com as possibilidades técnicas da TV Digital e das múltiplas telas, tão integradas ao cotidiano dos indivíduos.
A vivência da metodologia da problematização na formação docente
Authors: Hessel Ana Maria Di Grado , Portella da Costa Marina Moretzsohn , Montenssanti Mathias Maria Otilia José
Published: June 2018

O texto relata uma pesquisa referente ao uso da Metodologia da Problematização com o Arco de Maguerez, como método de ensino, desenvolvido em duas disciplinas do curso de Pedagogia da PUC/SP. O objetivo da pesquisa foi refletir sobre o ensino e aprendizagem, junto aos alunos do curso, os quais vivenciaram uma experiência didática. É uma pesquisa qualitativa de caráter exploratório. A experiência foi avaliada pelos alunos por meio de fichas avaliativas, postadas no ambiente Moodle. Esse ambiente também serviu como suporte para o desenvolvimento e acompanhamento das diferentes etapas da metodologia de problematização.  As respostas oriundas das avaliações discentes subsidiaram a análise e interpretação dos dados que revelaram as aprendizagens concretizadas bem como as contribuições para a formação docente crítica e reflexiva.Palavras-chave: Metodologia da Problematização. Método de Ensino. Formação Docente.
Educomunicación, televisión y valores. Análisis de la programación desde una óptica publicitaria
Authors: Zambrano Rodrigo Elías , Jiménez-Marín Gloria , Medina Irene García
Published: June 2018

Compreender a televisão como uma mera entidade de entretenimento é um conceito obsoleto. A definição tradicional da mídia com um propósito informativo também é pequena. No século XXI, damos um passo adiante: afirmamos que, além de informar e divertir, a mídia e, no caso que nos interessa, a televisão, forma. Educa. Portanto, começamos a partir da revisão da literatura existente, a partir de uma perspectiva de publicidade, para fazer uma análise da grade focada em alguns casos concretos comparáveis na televisão espanhola. E observamos como isso afeta à estratégia dos meios publicitários.
Undrained cyclic shear behaviour of weathered tephra
Authors: Kluger M. O. , Kreiter S. , Moon V. G. , Orense R. P. , Mills P. R. , Mörz T.
Published: June 2018

Weathered tephra is prevalent across volcanic islands like the North Island of New Zealand and is composed of volcanic airfall materials that have been subjected to various soil processes. Understanding their undrained response to cyclic loading is essential for geotechnical engineering applications in these regions because of frequently occurring local earthquakes. The authors describe for the first time the cyclic undrained behaviour of a weathered, clay-rich and highly sensitive tephra through triaxial tests. The weathered tephra experiences brittle failure and exhibits higher friction than sedimentary clays. Cyclic contour diagrams, covering the whole compressional and extensional range of stress conditions, are used to compare the cyclic shear strength of Pahoia tephra with those derived for sedimentary clays. It is found that weathered tephra: (a) is more resistant to small cyclic loading; (b) fails within a smaller range of cyclic shear stresses; and (c) exhibits a cyclic shear strength that peaks at zero average shear stress, in contrast to sedimentary clays where cyclic shear strength peaks at small compressive average stress.
Predicting relative humidity of early-age concrete under sealed and unsealed conditions
Authors: Shen Dejian , Zhou Baizhong , Wang Mingliang , Chen Ying , Jiang Guoqing
Published: June 2018

The decrease of internal relative humidity (IRH) in early-age concrete induces autogenous shrinkage. Autogenous shrinkage usually increases the risk of cracking if the concrete is restrained from shrinking freely at an early age. Predicting autogenous shrinkage of early-age concrete requires knowledge of IRH. Therefore, investigation of IRH is fundamental to evaluate cracking resistance. Although investigations of IRH in hardened concrete have been conducted, a prediction model for IRH in early-age concrete that considers the water/cement ratio (w/c) is still lacking. Therefore, experimental studies and analysis of IRH in early-age concrete with different values of w/c were conducted. Results showed that: (i) the IRH in concrete at 28 d after casting increased with increasing w/c under sealed and unsealed conditions; (ii) the average rate of IRH decrease in early-age concrete decreased with increasing w/c; (iii) the critical time of IRH (the length of the water-vapour saturated stage with 100% IRH) in early-age concrete increased with increasing w/c. Models for early-age IRH are proposed in consideration of w/c, critical time and age of concrete under sealed and unsealed conditions.
Hz. Lokman’ın Öğütleri ve Antik Mısır’ın Sebayt Metinleri
Authors: MERAL Yasin
Published: June 2018

Hz.

Lokman’ın Kur’an’daki öğütleri Türkçe ve yabancı dillerde pek çok çalışmaya konu olmuştur. Araştırmacılar, Hz. Lokman’ı farklı medeniyetlerdeki muhtelif bilgelerle özdeşleştirirken öğütleri de bu medeniyetlerdeki bilgelik literatürü içerisinde değerlendirmişlerdir. Bu makalede Hz. Lokman

ve öğütleri, araştırmacıların göz ardı ettiği Antik Mısır ve Sebayt metinleri çerçevesinde ele alınacaktır. Bu çerçevede bu makale, Hz. Lokman’ın Mısırlı bir bilge olabileceğini ve öğütlerinin de Antik Mısır’ın bilgelik literatürü olarak bilinen Sebayt metinlerinde aranabileceğini

iddia etmektedir.
Türk Mitolojisine Ait ‘Kutsal Ana’ İmgesinin Siyasal Antropoloji Bağlamında Değerlendirilmesi
Authors: BAŞTÜRK Efe
Published: June 2018

Mitoloji, bir toplumun kolektif hafızasının

bilinçaltını oluşturur. Mitolojik göstergeler, yalnızca destansı özellikler

taşımaz; onlar ayrıca bir toplumun politik ve hukuki anlamda nasıl

örgütlendiğine ilişkin ipucu sunarlar. Bu bakımdan bir toplumun politik

örgütlenmesi, kolektif bilinci yapılandıran arketipler vasıtasıyla

anlaşılabilir. Bu çalışma, arketiplerin mitolojik varyantlarına odaklanarak

Eski Türk toplumlarındaki “kutsal Ana” imgesine değinecektir. Eski Türk

toplumlarında kutsal Ana imgesine yüklenen animist anlam, kendisini, anahanlı

politik sistemde göstermektedir. Anahanlık, arkaik Türk toplumunun, bir

taraftan doğa ile bütüncül ilişkisini, diğer taraftan ise bu bütüncül ilişkiden

kaynaklanan siyasal[lık] düzeyini yansıtmaktadır. Anahanlı bir siyasal sistem,

doğa ile kurulan ilişkinin hem imgesel-arketipsel düzeyini, hem de tüm bu

süreçler yoluyla inşa edilen politik-hukuki bir yapıyı işaret eder. Türk

toplumunun arkaik varoluş biçimi olarak anahanlık, kadın imgesine yüklenen

“kutsallık” anlamını, “farklılaşmamış” (doğa ile bütüncül varoluş) bir siyasal

sistem vasıtasıyla kurar. Bu çalışma, siyasal antropoloji perspektifine

dayanarak arkaik Türk toplum yaşamını ilgili arketipler üzerinden tartışmayı

amaçlamaktadır.
Ekrem Sarıkçıoğlu, Kanonik-Apokrif İncillere Göre Hz. İsa Ha-yatı ve Mesajı
Authors: BAKIŞGAN Muhammed Hanifi
Published: June 2018

İnsanlık tarihinde krallar, bilim adamları, kahramanlar, komutan-lar, din kurucuları ve daha sayamadığımız birçok ünlü sima gelip geçmiştir. Şüphesiz bunlar arasında gerek yaşadıkları dönem içeri-sinde gerekse kendilerinden sonra devasa kitleleri etkileyen kişiler-den söz edilebilir. Bahsettiğimiz bu kimseler, din kurucularından başkaları değildir.
Dependence of the Result on the Effectiveness of Performance in the World Women’s Handball Championship 2016
Authors: Križan M. , Mikulič M.
Published: June 2018

The aim of the thesis was to analyze selected indicators of the game performance of the representative team in the defensive and offensive phases of the Slovak cadets’ game, depending on the result of the match.

Materials and methods. In the thesis, we assumed that we would find a statistically significant relationship between the observed performance indicators and the result of the match. To obtain the research data, we used indirect observation of seven World Championship cadet matches of 2016. We used Hianik (2010) to diagnose game performance. We analyzed selected indicators of the game performance of the representative team of Slovak cadets (n=18), depending on the result of the match.

Results. We found out that the result of the match is influenced by the game performance of the team in the defensive and offensive phases of the game. Furthermore, we have drawn the conclusion that the game result is also influenced by the performance of the goalkeeper (p<0.01).

Conclusions. The thesis highlighted the importance of the game performance of the team both in the defensive and the offensive phases of the game as well as the performance of the goalie in the match. The results obtained showed statistical significance (p<0.01) and proved that the outcome of the match is influenced by the successful team play in attack and defense. Also, the result of the match depends on the goalkeeper’s performance. We recommend using the computer program Hianik (2010) to evaluate the game performance of the team in the game.
NCT03171688 - clinical protocol v1
Authors: Magalhães Nunes Guimarães Gabriel
Published: June 2018

A single prospective cohort of women submitted to cesarean section who received spinal anesthesia will be assessed for the proposed risk factors and the incidence of nausea or vomiting will be observed during the first 48 hours.