bluuebunny/crossref_metadata_2025 huggingface dataset:
Robust tracking control in the inertia phase for generalised disturbance
Authors: Cao Guoxiang , Wang Anlin , Li Xiaotian , Xu Donghuan , Fan Xucan
Published: September 2020

To solve the problem of shift shock during the inertia phase caused by generalized disturbances in wheel loaders and other construction instruments, a robust double closed-loop tracking control method based on an improved disturbance observer (DOB) has been proposed. In this method, the inner loop robustly suppresses disturbance and the outer loop realizes trajectory tracking. The improved DOB based on a nominal disturbance value (NDV) can enhance the disturbance suppression ability of the inner loop when a large part of the generalized disturbance is determinable. The model matching method transforms the outer loop into a transfer function to meet the expected performance. A disturbance compensation controller eliminates the nominal disturbance in the system. A feedforward compensation controller eliminates the influence of reference inputs in the system. Considering the inertia phase of a fixed-axis automatic transmission of a wheel loader, the proposed method was applied to the driveline simulation platform of a specific type of wheel loader. Random loads under actual working conditions were considered as the input load of the simulation platform. The simulation results indicated that the DOB based on the NDV method has better disturbance suppression capability, more accurate tracking capability and smaller shift shock than the conventional DOB method. The proposed control method exhibits robustness under 10%, 50% and 90% of the maximum load. The highest shift shock is 4.94% of the manual shift shock and it is effectively reduced. Thus, robust and smooth inertia phase shift control of the automatic transmission can be realized. This study presents an effective method for solving robust disturbance suppression control problems and tracking control problem under large generalized disturbances.
Pattern discovery of health curves using an ordered probit model with Bayesian smoothing and functional principal component analysis
Authors: Wang Shijia , Nie Yunlong , Sutherland Jason M , Wang Liangliang
Published: September 2020

This article is motivated by the need for discovering patterns of patients’ health based on their daily settings of care to aid the health policy-makers to improve the effectiveness of distributing funding for health services. The hidden process of one’s health status is assumed to be a continuous smooth function, called the health curve, ranging from perfectly healthy to dead. The health curves are linked to the categorical setting of care using an ordered probit model and are inferred through Bayesian smoothing. The challenges include the nontrivial constraints on the lower bound of the health status (death) and on the model parameters to ensure model identifiability. We use the Markov chain Monte Carlo method to estimate the parameters and health curves. The functional principal component analysis is applied to the patients’ estimated health curves to discover common health patterns. The proposed method is demonstrated through an application to patients hospitalized from strokes in Ontario. Whilst this paper focuses on the method’s application to a health care problem, the proposed model and its implementation have the potential to be applied to many application domains in which the response variable is ordinal and there is a hidden process. Our implementation is available at https://github.com/liangliangwangsfu/healthCurveCode .
Effects of Country Risk Shocks on the South African Bond Market Performance Under Changing Regimes
Authors: Muzindutsi Paul-Francois , Obalade Adefemi A.
Published: September 2020

Country risk can significantly impact the flow of investment within a country. The bond market is particularly vulnerable to country risk shocks, as such risks affect government borrowing and lending rates. This article analysed the effect of country risk components on the South African (SA) bond market performance and stability under different market regimes. A sample period of monthly data, spanning January 1995 to December 2018, was selected to reflect South Africa’s shift towards democracy (post 1994). Two-stage Markov switching models (MSMs) were utilized to test the effect of country risk components on bond market return and yield spreads. First, the study showed that both returns and spread undergo a longer bullish trend. Second, the effect of country risks on bond returns was shown to be significant only in the bear regime in which bond returns increase with a change in political and economic risks and decrease with a change in financial risk. Third, the effect of the country risk components on yield spreads was shown to be not significant in any regime. We concluded that the response of bond market performance to country risk shocks is influenced by market cycles, and we provide evidence to support the adaptive market hypothesis (AMH) in the SA bond market.
Association Between Parity and the Age at Menopause and Menopausal Syndrome in Northwest China
Authors: Sun Xiaoyan , Zhang Rui , Wang Lirong , Shen Xiping , Lu Yongbin , An Junxia , Wang Liyan , Wang Yiqing , Luo Xiaorong , Zhu Haiying , Zhang Xuehong
Published: September 2020

This study evaluated the relationships between parity and the age at menopause and menopausal syndrome among Chinese women in Gansu. A total of 7236 women aged 40 to 55 years met study eligibility criteria. The modified Kupperman Menopausal Index scale was used to assess the severity of menopausal syndrome. Cox regression was applied to estimate hazard ratio and 95% confidence interval, and logistic regression was performed to calculate odds ratio and confidence interval. The mean age at menopause was 47.91 ± 3.31 years. There is no relationship between parity and age at menopause. Women with nulliparity or multiparity seemed to have higher risks of moderate and severe menopausal syndrome. The potential beneficial effects of one or two births on menopausal syndrome were also observed by applying the multivariable logistic regression analysis, particularly in urogenital symptoms. Women with nulliparity and multiparity appeared to be at the higher risks of menopause syndrome.
Grounded in Culture: Reflections on Sitting Outside the Circle in Community-Based Research With Indigenous Men
Authors: Waddell Candice M. , Herron Rachel V. , Gobeil Jason , Tacan Frank , De Jager Margaret , Allan Jonathan A. , Roger Kerstin
Published: September 2020

Research continues to be a dirty word for many Indigenous people. Community-based participatory research (CBPR) is a means to disrupt power dynamics by engaging community members within the research process. However, the majority of relationships between researcher and participants within CBPR are structured within Western research paradigms and they often reproduce imbalances of power. The purpose of this article is to reflect on the process of CBPR within a research project focused on Indigenous men’s masculinity and mental health. In doing so, we aim to contribute to reflexive practice in CBPR and flatten research hierarchies to facilitate more equitable knowledge sharing. Our reflections highlight the importance of prioritizing healing, centering cultural protocols, negotiating language, and creating space for Indigenous research partners to lead. These critical lessons challenge Western researchers to ground their practices in Indigenous culture while they “sit outside the circle” to facilitate more equitable and engaged partnerships.
Reliability and Predictive Validity of Dental Arch Relationships Using the 5-Year-Olds’ Index and the GOSLON Yardstick to Determine Facial Growth
Authors: Pegelow Marie , Rizell Sara , Karsten Agneta , Mark Hans , Lilja Jan , Chalien Midia Najar , Lemberger Mathias , Peterson Petra , Fitzsimons Kate , Deacon Scott , Medina Jibby , Calvert Mary , Mars Michael
Published: September 2020

Aims:

To determine reliability and predictive validity of the 5-year-olds’(5YO) Index and GOSLON Yardstick in 119 patients born with unilateral cleft lip and palate at 5, 7/8, 10, 15/16, and 19 years.

Methods:

Five hundred thirty-four dental study models were appraised by 2 teams in 2 centers, twice in each center. Intrateam and interteam reliability in scoring the models was calculated using κ. Dental arch prediction rates were calculated as the proportion of models remaining in the same category (good–scores 1 and 2; fair–score 3; poor–scores 4 and 5) over time.

Results:

Intrateam and interteam κ statistics ranged from 0.74 to 0.89 and from 0.74 to 0.81, respectively. The 5YO Index and GOSLON Yardstick at 5 years produced almost identical results. The prediction rate of 19-year-old (n = 106) outcome was >80% for those in groups 1 and 2 at 5 years, while for those in groups 4 and 5 prediction was poor (<40%). Prediction of groups 4 and 5 remained poor until 10 years when it increased to 77%. At 15/16 years prediction rate was 93% for those in groups 4 and 5. Prediction of cases in group 3 was very poor at all ages.

Conclusions:

These results question the predictive value of “poor” dental arch relationships before 10 years of age. However, the predictive value of “good” dental arch relationship scores over time is good in all age groups. This has implications for audit policies to predict facial growth outcomes.
Quarantine Life Is Stillness and Dialogue: A Reflective Autoethnography During a Global Pandemic
Authors: Zheng Shiyu (Sharon)
Published: September 2020

This reflective autoethnography uses writing, photos, and audio recordings to present my 14-day quarantine in times of COVID-19 from arriving in China, meeting my handler, developing relationships through online chats, to helping others out in a Chinese hotel. This article serves as a reference for people in quarantine to fight against the fear, frustration, and depression that can arise from being isolated. Experiencing friendliness during these struggles, especially some of the self-inspiration and encouragement that can be stimulated by friendliness, will support us to change the way we think, live, and deal with difficulties, not just now but in future.
Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics
Authors: Fiume Monice M. , Bergfeld Wilma F. , Belsito Donald V. , Hill Ronald A. , Klaassen Curtis D. , Liebler Daniel C. , Marks James G. , Shank Ronald C. , Slaga Thomas J. , Snyder Paul W. , Gill Lillian J. , Heldreth Bart
Published: September 2020

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 60 PEGylated alkyl glycerides. PEGylated alkyl glycerides are mono-, di-, and/or triglycerides that have been modified with ethylene glycol repeat units (in the starting material form as epoxide). Most of the PEGylated alkyl glycerides are reported to function as skin-conditioning agents or surfactants. The Panel reviewed the available animal and clinical data as well as data from the 1999 report for the 5 polyethylene glycol (PEG) glyceryl cocoates and the 2012 report of PEGylated oils, to determine the safety of these ingredients. The Panel concluded these ingredients are safe in the current practices of use and concentration when formulated to be nonirritating; this conclusion supersedes the 1999 conclusion issued on 5 PEG glyceryl cocoate ingredients.
Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells
Authors: Şekeroğlu Zülal Atlı , Şekeroğlu Vedat , Küçük Nihan
Published: September 2020

High telomerase activity in human breast cancer is associated with aggressive tumors resulting in decreased survival. Recent studies have shown that telomerase inhibitors may display anticancer properties in some human cancer cell lines. In the present study, we examined the effects of 4 reverse transcriptase inhibitors (RTIs), used for the treatment of HIV; Abacavir (AC), Lamivudine (LV), Stavudine (SV), and Tenofovir (TF) on proliferation, apoptosis, and migration in the normal human mammary epithelial cell line, hTERT-HME1, and the human breast cancer cell line, MCF-7. Cells were treated with AC, LV, SV, or TF alone or in combination with paclitaxel (PAC), a known drug used to treat breast cancer. Conduct of the thiazolyl blue tetrazolium bromide assay demonstrated that AC, SV, and TF had stronger cytotoxic effects on MCF-7 cells than in hTERT-HME1 cells. The combined treatment of RTIs and PAC caused high rates of cell death in MCF-7 and low rates of cell death in HTERT-HME1 by apoptosis. The percentages of apoptotic cells in the treatment of AC and SV in combination with PAC for 48 and 72 hours were higher than PAC. Significantly increased apoptosis and decreased migration levels were found in MCF-7 cells treated with AC and co-treatment of AC+PAC or SV+PAC than HME1 cells. These treatments can also prevent migration capacity more than PAC. Therefore, a combination strategy based on telomerase inhibitors such as AC or SV and anticancer drugs may be more effective in the treatment of certain breast cancers.
Effect of Changes in Land-Use Management Practices on Soil Physicochemical Properties in Kabe Watershed, Ethiopia
Authors: Assefa Fikru , Elias Eyasu , Soromessa Teshome , Ayele Gebiaw T
Published: September 2020

Change in land-use management practices such as cultivation of steep slopes, overgrazing, and no or limited fallow periods, and slope position affects the quality of soils. As a result, assessing soil physicochemical properties and subsequent implications on soil fertility is essential for understanding the influence of agro-ecosystem revolution on agricultural soil quality and efficiency. In this research, we assessed the effect of land-use management practices on selected soil properties under varying terrain slopes and with and without soil conservation measures in a highly disturbed landscape in the northern part of Ethiopia in 2016. Based on the result, for all slope positions considered—namely, lower (1%-15%), middle (15%-30%), and upper (30%-45% and above)—with and without soil conservation, soil moisture content, porosity, silt, and clay proportions were lower in the cultivated land compared with grazing and forestland-use units. Conversely, soil bulk density and the sand fraction were higher in the cultivated land than grazing and forestland units, relatively. Observing changes in a terrain slope position, sand content of forest, grazing, and cultivated land units increased from lower to upper slope position whereas silt and clay fraction generally showed a decreasing trend from lower to an upper slope positions. In all slope positions with and without conservation practice, cation exchange capacity, exchangeable K+, Ca2+, and Mg2+ showed a significant increase from cultivated land to grazing and then forestland. The mean value of pH and electrical conductivity of cultivated lands with and without soil conservation were significantly low in all slope categories. Summarizing the analysis of variance for selected soil chemical properties with different slope positions, except available phosphorous, all chemical properties considered in this study are statistically significant ( P < .05). In summary, the result confirmed that soil properties were strongly influenced by terrain slope, land use, and changes in management practice. Consequently, to conserve soil resources, policymakers need to implement appropriate land conservation strategies based on land-use structure and slope variation.
“YES it’s the Perfect Time to Quit”: Fueling Tobacco Cessation in India during COVID-19 Pandemic
Authors: Grover Shekhar , Mohanty Vikrant , Jain Swati , Anand Tanu , Aghi Mira B
Published: September 2020

Entire world is battling the Novel Coronavirus Disease (COVID-19) pandemic. India too, has undertaken stringent containment measures to combat this disease. The country is in a state of national lockdown, which has inadvertently led more than a quarter of the Indian population to not use tobacco. This paper discusses the opportunity that surfaces with unavailability of tobacco products, and advocates the need for escalation of tobacco cessation services as well as strategic management of stress to stay tobacco-free.
School performance, psychiatric comorbidity, and healthcare utilization in pediatric multiple sclerosis: A nationwide population-based observational study
Authors: Boesen Magnus Spangsberg , Blinkenberg Morten , Thygesen Lau Caspar , Eriksson Frank , Magyari Melinda
Published: September 2020

Background:

Pediatric multiple sclerosis (MS) may hamper educational achievements due to psychiatric comorbidity and cognitive impairment. Our aims were to investigate school performance, psychiatric comorbidity, and healthcare utilization following pediatric MS and to differentiate between disability in MS and that arising from a non-brain-related chronic disease.

Methods:

We included all children (<18 years) with MS onset during 2008–2015 in Denmark with a medical record–validated MS diagnosis. The control groups were children from the general population or children with non-brain-related chronic diseases. Outcomes were register-based on 9–12 grade point average, psychiatric comorbidity, and healthcare visits.

Results:

Cohorts were children with MS ( n = 92), control children matched to children with MS ( n = 920), children with non-brain-related chronic diseases ( n = 9108), and “healthy” children with neither MS nor brain-related chronic disease ( n = 811,464). School performance in grades 9–12 was similar, but children with MS compared to those with non-brain-related chronic disease had an almost doubled hazard for psychiatric comorbidity (hazard ratio = 1.87; 95% confidence interval = 1.38–2.53; p < 0.0001) and a higher rate of all hospital visits ( p < 0.0001) but a lower rate of hospital admissions ( p = 0.001).

Conclusion:

Children with MS have a seemingly standard school performance but increased psychiatric comorbidity and a high rate of healthcare utilization.
Anxiety and depression affect performance on the symbol digit modalities test over time in MS and other immune disorders
Authors: Marrie Ruth Ann , Patel Ronak , Bernstein Charles N , Bolton James M , Graff Lesley A , Marriott James J , Hitchon Carol A , Figley Chase R , Kornelsen Jennifer , Fisk John D
Published: September 2020

Background:

Longitudinal studies assessing depression and anxiety effects on cognition in multiple sclerosis (MS) are limited.

Objective:

We tested whether within-person fluctuations in symptoms of depression or anxiety over time affect cognition in persons with MS, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and a lifetime history of depression/anxiety disorders (DEP/ANX) but without an immune-mediated inflammatory diseases (IMID).

Methods:

We followed participants (MS: 255, IBD: 247, RA: 154, and DEP/ANX: 306) for 3 years. Annually, they completed the hospital anxiety and depression scale (HADS) and cognitive tests including the symbol digit modalities test (SDMT). We evaluated associations of elevated symptoms (scores ⩾ 11) of anxiety (HADS-A) and depression (HADS-D) with SDMT z-scores using multivariable linear models—estimating between-person and within-person effects.

Results:

Participants with MS performed worse on the SDMT than participants in the DEP/ANX cohort (β = −0.68; 95% CI: −0.88, −0.48). Participants with elevated HADS-A scores performed worse on the SDMT than those without elevated scores (β = −0.43; 95% CI: −0.65, −0.21), particularly those with RA. Time-varying within-person elevations in depressive symptoms were associated with worse SDMT performance (β = −0.12; 95% CI: −0.21, −0.021).

Conclusions:

Across persons, elevated symptoms of anxiety adversely affected information processing. Elevated symptoms of depression within-persons over time were associated with declines in information processing speed.
Calf muscle pump function as a predictor of all-cause mortality
Authors: Halkar Meghana , Medina Inojosa Jose , Liedl David , Wysokinski Waldemar , Houghton Damon E , Wennberg Paul W , Lin Grace , Kane Garvan , Fischer Karen , Rooke Thom W , Saadiq Rayya , Bonikowske Amanda , McBane Robert D
Published: September 2020

Calf muscle pump (CMP) promotes venous return from the lower extremity and contributes to preload and cardiac output. Impaired CMP function may reflect a measure of frailty or cumulative disease burden or may impede cardiac function. The study objective was to test the hypothesis that impaired CMP negatively impacts survival. Consecutive adult patients who underwent venous strain gauge plethysmography at the Mayo Clinic Gonda Vascular Laboratory (January 1, 1998 – December 31, 2011) were assessed for overall survival. Patients with venous incompetence, venous obstruction or unilateral calf pump dysfunction were excluded. Risk of mortality was assessed with Cox proportional hazard ratios and after adjusting for Charlson Comorbidity Index variables. Over the study period, 2728 patients were included in the analysis. Compared to patients with normal CMP, those with impaired CMP were older ( p < 0.001), predominantly female ( p = 0.01) and had higher mean Charlson scores ( p < 0.001). Patients with impaired CMP had a higher mortality rate at 5 (8.9% vs 2.4%), 10 (17.5% vs 5.9%), and 15 years (22.8% vs 8.3%) compared to those with normal CMP ( p < 0.001 for each comparison). Of patients with heart failure, those with impaired CMP had worse survival at each 5-year increment compared to those with normal CMP ( p < 0.05 at each increment). In conclusion, impaired CMP appears to be an independent predictor of poor outcomes after adjusting for variables within the Charlson Comorbidity Index. The association between impaired CMP, heart failure, and mortality may represent a negative impact on circulatory function or a surrogate measure of frailty.
Reflections in shadow: Excavating the personal archives of Paul Jacobsthal and EM Jope
Authors: Hitchcock Matthew William
Published: September 2020

The formation of archives has been a key facet of the archaeological discipline since its inception, critical in the production of knowledge from the destructive excavation that occurs in the field. The ongoing ‘archival shift’ within the humanities from archives as mere sources of secondary information to primary topics of research has presented new potential for the study of historic archaeological archives. This article explores the personal archives of two great scholars of Iron Age Celtic art, Paul Jacobsthal and EM Jope, held at the Institute of Archaeology, University of Oxford. Shedding new light on their engagement and interaction with the objects that they studied, the author explores the archive’s power to illuminate the ways in which the scholars’ methods, experiences and encounters shaped the knowledge that they produced about the past. Through presenting the archives as both primary sources of historical information and vibrant material entities, worthy of ‘excavation’ in their own right, the article advocates an assemblage-based archaeological approach to archival engagement.
Extreme value modeling of coincident lane load effects for multi-lane factors of bridges using peaks-over-threshold method
Authors: Zhou Junyong , Hu Cuimin , Chen Zhixing , Wang Xiaoming , Wang Tao
Published: September 2020

Multi-lane factor (MLF) is a probability reduction reflecting unfavorable traffic loads over multiple lanes acting simultaneously on the most adverse position of a bridge. It is one of the key components of traffic load models for bridges. The most recent research established a multi-coefficient MLF model that clearly illustrated the lane load disparity and the probability reduction of their simultaneous actions. However, it used the block maxima (BM) method for extreme value modeling, which requires a large amount of traffic data. This study aims to adopt the peaks-over-threshold (POT) method to obtain more information from short-term traffic data and model the extreme coincident lane load effects (LLEs) for multi-coefficient MLF calibration. First, the multi-coefficient MLF model was reviewed. Thereafter, the bivariate POT method for coincident LLEs modeling using generalized Pareto distribution was proposed and formulated. Critical issues such as bivariate threshold selection and parameter estimation were addressed. Numerical examples were demonstrated to verify and validate the approach. Finally, the proposed approach was applied for calibrating the MLF of an experimental site with four traffic lanes. The results indicated that the coincident LLEs modeling using the POT approach was accurate and more effective than using the BM method when applied to limited data. The calibrated MLFs from the experimental site effectively revealed the lane load disparity of traffic loads over multiple lanes, which is not involved in the traffic load models of current bridge design specifications. Furthermore, the influence of other problems such as weight restriction on coincident LLEs modeling and MLF calibration were discussed. The proposed technique provides a sound approach for multi-coefficient MLF calibration of bridge assessment with short-term site-specific traffic data.
Improving mental health in U.S. Veterans using mHealth tools: A pilot study
Authors: Latour Chase , O’Byrne Lorcan , McCarthy Margaret , Chacko Ravi , Russell Elizabeth , Price Rumi Kato
Published: September 2020

Rates of PTSD remain elevated among U.S. Veterans, highlighting a need for innovative management tools. Previous studies have shown mobile apps to have positive effects on PTSD symptoms, but few apps have been examined systematically. This pilot study evaluated the perceived effectiveness and usability of Mindset, a novel mobile app that monitors user stress level via heart rate to encourage e-therapy use. The study sample included 30 community-residing Veterans who completed baseline assessments. They used the Mindset app and associated smartwatch until their approximate 1-month follow-up. Self-reported assessments included pre- and post-deployment experiences; experience with Mindset; and standard screeners for PTSD (PCL-M), anxiety (GAD-7), depression (PHQ-9), and alcohol use problems (AUDIT). Among the 24 participants who completed follow-up interviews, a significant decrease ( p < 0.05) was found in PCL-M, PHQ-9, and modified AUDIT scores. Respondents reported moderate to high acceptance and satisfaction with Mindset features, though considerable frustration with the associated smartwatch. These findings highlight mHealth apps such as Mindset as potentially useful tools for PTSD and depression symptom management. These findings are also encouraging in the context of the current COVID-19 pandemic, which may accelerate further innovation and implementation of mHealth technologies to improve mental health self-care.
The Politics of Merely Following: Witnessing AIDS on Instagram
Authors: Griffin Hollis
Published: September 2020

Using an illustrative sample of posts to an Instagram account devoted to commemorating lives lost to AIDS, this article articulates a less-than-intense form of engagement with lesbian, gay, bisexual, transgender, and queer (LGBTQ+) politics on social media. Merely following particular accounts on social media networks enables an encounter with an Other that is shaped by the affordances of digital technologies and the specificities of particular platforms. A site of political engagement that is further contoured by hierarchies of sex, race, and gender, @theaidsmemorial offers evidence of user experiences that are less focused and intentional than those typically associated with progressive sexual politics. Nevertheless, the author argues that they are meaningful because of how they expose users to bodies, lives, and desires they may not encounter if not for social media.
Influence of Angiotensin II on cell viability and apoptosis in rat renal proximal tubular epithelial cells in in vitro studies
Authors: Piotrowska Aleksandra , Chmielewska Magdalena , Andrzejewski Waldemar , Dziegiel Piotr , Podhorska-Okolow Marzenna
Published: September 2020

Introduction:

Angiotensin II (Ang II) is multifunctional peptide that plays an important role in blood pressure regulation and maintenance electrolyte homeostasis. It shows biological effects by activating two main receptors: AT1 and AT2. The aim of the present work was to investigate the effect of Ang II on NRK-52E cells in in vitro studies. Furthermore, an attempt was made to determine the effectiveness of the AT1 and AT2 receptor blocker activity (respectively, losartan and PD123319).

Methods:

The study was carried out using adherent NRK-52E cell line. Immunofluorescence and Western Blot method were used to confirm the presence of AT1 and AT2 receptors in the cells. The SRB and MTT tests showed decrease in the viability of NRK-52E cells incubated with Ang II in comparison to the control (without Ang II).

Results:

The blockade of the AT1 receptor caused an increase in cell viability in comparison to cells incubated with Ang II only. The blockade of AT2 receptor also triggered statistically significant increase in cell viability in comparison with cells only exposed to Ang II. Combined administration of blockers for both receptors (losartan and PD123319) decreased Ang II cytotoxicity against NRK-52E cell line. The apoptosis was only observed in cells incubated with Ang II in comparison with control cells. However, simultaneous use of both blockers caused statistically significant decrease in apoptosis.

Conclusions:

The result of our study indicates that Ang II causes damaging effect on NRK-52E cells by directing them to programmed cell death. It seems that not only does the AT2 receptor itself play an important role in the induction of apoptosis, but also its interaction with AT1 receptor does as well.
Reimagining teacher subjectivity in Pacific early childhood education in New Zealand
Authors: Matapo Jacoba , Teisina Jeanne
Published: September 2020

This article presents a transnational Moana talanoa 1 between two Pacific early childhood education scholars. Calling on both Samoan and Tongan indigenous understandings that breathe life into a Moana subjectivity is inclusive of ways of knowing, relating and becoming. We turn our attention to the importance of talanoa (stories/storying) in reconstituting olaga 2 and tangata kakato 3 in the act of decolonising Pacific 4 personhood in New Zealand early childhood education. Moana, the waters that bind Pacific peoples through genealogy, relationality and cosmogony, generate intersubjectivity; a folding of past-present-futures. It is in the spirit of Moana that we bring attention to the interconnectedness of subjects in the context of early childhood education in New Zealand. By way of movement in and with Moana, the currents, depth and flows, we problematise politics of early childhood education and professional teacher identity. Such tensions require navigation and as Hawaiian scholar Meyer said: ‘How one knows, indeed, what one prioritises with regards to this knowing, ends up being the stuffing of identity, the truth that links us to our distant cosmologies, and the essence of who we are as Oceanic peoples’ (p. 125). In thinking-Moana-intersubjectivity, we call into question how the agency and subjectivity of teacher identity can be reimagined. We share our narratives through poetry and story as a mode of expression in analysing and decolonising personhood.
Special Report on the Impact of the COVID-19 Pandemic on Clinical EEG and Research and Consensus Recommendations for the Safe Use of EEG
Authors: Campanella Salvatore , Arikan Kemal , Babiloni Claudio , Balconi Michela , Bertollo Maurizio , Betti Viviana , Bianchi Luigi , Brunovsky Martin , Buttinelli Carla , Comani Silvia , Di Lorenzo Giorgio , Dumalin Daniel , Escera Carles , Fallgatter Andreas , Fisher Derek , Giordano Giulia Maria , Guntekin Bahar , Imperatori Claudio , Ishii Ryouhei , Kajosch Hendrik , Kiang Michael , López-Caneda Eduardo , Missonnier Pascal , Mucci Armida , Olbrich Sebastian , Otte Georges , Perrottelli Andrea , Pizzuti Alessandra , Pinal Diego , Salisbury Dean , Tang Yingying , Tisei Paolo , Wang Jijun , Winkler Istvan , Yuan Jiajin , Pogarell Oliver
Published: September 2020

Introduction

The global COVID-19 pandemic has affected the economy, daily life, and mental/physical health. The latter includes the use of electroencephalography (EEG) in clinical practice and research. We report a survey of the impact of COVID-19 on the use of clinical EEG in practice and research in several countries, and the recommendations of an international panel of experts for the safe application of EEG during and after this pandemic.

Methods

Fifteen clinicians from 8 different countries and 25 researchers from 13 different countries reported the impact of COVID-19 on their EEG activities, the procedures implemented in response to the COVID-19 pandemic, and precautions planned or already implemented during the reopening of EEG activities.

Results

Of the 15 clinical centers responding, 11 reported a total stoppage of all EEG activities, while 4 reduced the number of tests per day. In research settings, all 25 laboratories reported a complete stoppage of activity, with 7 laboratories reopening to some extent since initial closure. In both settings, recommended precautions for restarting or continuing EEG recording included strict hygienic rules, social distance, and assessment for infection symptoms among staff and patients/participants.

Conclusions

The COVID-19 pandemic interfered with the use of EEG recordings in clinical practice and even more in clinical research. We suggest updated best practices to allow safe EEG recordings in both research and clinical settings. The continued use of EEG is important in those with psychiatric diseases, particularly in times of social alarm such as the COVID-19 pandemic.
Electromagnetic interference shielding characteristics of a core layer-coated fabric with excellent hand-feel characteristics
Authors: Xu D , Yang WW , Jiang HM , Fan H , Liu KS
Published: September 2020

Electromagnetic shielding fabric (ESF) is a novel electromagnetic shielding product with portability, flexibility, and good mechanical properties. However, the existing ESFs suffer from poor washing fastness of coating and poor comfort performance in terms of hand-feel characteristic. In this study, a core layer-coated yarn (CLCY) was successfully spun using a carboxylic acid-functionalized multi-walled carbon nanotube/polypyrrole/Fe3O4 composite suspension with polyvinyl butyral as an adhesive agent. To better explore the properties, the original fabric and treated fabrics, viz., core layer-coated fabric (CLCF) and surface layer-coated fabric (SLCF), were characterized by several methods. Scanning electron microscopic observations revealed that the coating was on the core layer in CLCF. In addition, the Fourier-transform infrared spectroscopy and X-ray diffraction spectroscopy results revealed that the composition of the coating corresponds with that in the multi-composite suspension. Moreover, the coating of CLCY formed a conductive path with good conductivity in the core layer, but the conductivity of the coating on the surface layer of SLCF deteriorated sharply after washing. Further, compared with the original fabric and SLCF, CLCF has highest breaking strength (after 10 washes), and keeps a relatively good hand-feel characteristic. Finally, the evaluated electromagnetic interference shielding characteristics reveal that the fastness of coating affects the electromagnetic shielding effectiveness, suggesting that the wrapped protection of outside staple fibers in CLCF reduce the loss of coating in the core layer during washing. However, the coating on the surface layer in SLCF could be washed away easily.
Short-term retention of proprioceptive information
Authors: Horváth Áron , Ragó Anett , Ferentzi Eszter , Körmendi János , Köteles Ferenc
Published: September 2020

The Joint Position Reproduction test (JPR), one of the most widely used measurements to estimate proprioceptive accuracy, requires the short term storage of proprioceptive information. It has been suggested that visuospatial sketchpad plays a fundamental role in the memorization of proprioceptive information. The current study aimed to investigate this assumption. To do so, we developed and used a novel JPR protocol to measure the retention capacity with respect to sequences of different positions. Our goal was to develop the original task further to make it comparable with other widely used short-term memory measurements, in which the memory capacity was determined by the number of the items participants retain (memory span). We compared participants’ (N=39) performance in this task to that of results of Corsi block-tapping task (capacity of the visuospatial sketchpad) and Digit span task (capacity of the phonological loop). Proprioceptive memory capacity did not correlate either with spatial or verbal memory capacity. The exploratory analysis revealed that proprioceptive span correlated positively with the performance if 5 joint positions had to be retained. Further associations with verbal span for 6 or 7 positions, and spatial span for 5 positions were found. Our findings do not support the idea that visuospatial sketchpad plays a fundamental role in the storage of proprioceptive information. The independence of span measures indicates that proprioceptive information might be stored in a subsystem independent of the visuospatial sketchpad or phonological loop.
Eye movement control in Turkish sentence reading
Authors: Özkan Ayşegül , Beken Fikri Figen , Kırkıcı Bilal , Kliegl Reinhold , Acartürk Cengiz
Published: September 2020

Reading requires the assembly of cognitive processes across a wide spectrum from low-level visual perception to high-level discourse comprehension. One approach of unravelling the dynamics associated with these processes is to determine how eye movements are influenced by the characteristics of the text, in particular which features of the words within the perceptual span maximise the information intake due to foveal, spillover, parafoveal, and predictive processing. One way to test the generalisability of current proposals of such distributed processing is to examine them across different languages. For Turkish, an agglutinative language with a shallow orthography–phonology mapping, we replicate the well-known canonical main effects of frequency and predictability of the fixated word as well as effects of incoming saccade amplitude and fixation location within the word on single-fixation durations with data from 35 adults reading 120 nine-word sentences. Evidence for previously reported effects of the characteristics of neighbouring words and interactions was mixed. There was no evidence for the expected Turkish-specific morphological effect of the number of inflectional suffixes on single-fixation durations. To control for word-selection bias associated with single-fixation durations, we also tested effects on word skipping, single-fixation, and multiple-fixation cases with a base-line category logit model, assuming an increase of difficulty for an increase in the number of fixations. With this model, significant effects of word characteristics and number of inflectional suffixes of foveal word on probabilities of the number of fixations were observed, while the effects of the characteristics of neighbouring words and interactions were mixed.
To stay or not to stay: The stability of choice perseveration in value-based decision making
Authors: Senftleben Ulrike , Schoemann Martin , Rudolf Matthias , Scherbaum Stefan
Published: September 2020

In real life, decisions are often naturally embedded in decision sequences. In contrast, in the laboratory, decisions are oftentimes analysed in isolation. Here, we investigated the influence of decision sequences in value-based decision making and whether the stability of such effects can be modulated. In our decision task, participants needed to collect rewards in a virtual two-dimensional world. We presented a series of two reward options that were either quick to collect but were smaller in value or took longer to collect but were larger in value. The subjective value of each option was driven by the options’ value and how quickly they could be reached. We manipulated the subjective values of the options so that one option became gradually less valuable over the course of a sequence, which allowed us to measure choice perseveration (i.e., how long participants stick to this option). In two experiments, we further manipulated the time interval between two trials (inter-trial interval), and the time delay between the onsets of both reward options (stimulus onset asynchrony). We predicted how these manipulations would affect choice perseveration using a computational attractor model. Our results indicate that both the inter-trial interval and the stimulus onset asynchrony modulate choice perseveration as predicted by the model. We discuss how our findings extend to research on cognitive stability and flexibility.
Nitrite Scavenging and Inhibition of N-Nitrosamines Formation by Phenolic Extracts From Diospyros lotus L. Leaves and Active Ingredients
Authors: Tian YanHua , Du HuiZhi , Wang Li , Li ShiFei , Zhang Lu , Zhang LiWei
Published: September 2020

Diospyros lotus L. leaves are used as a functional tea and folk medicine in several Asian countries. This study aimed to evaluate the effects of phenolic extracts of the leaves on scavenging nitrite and inhibiting N-nitrosamines (NAs) formation and to determine the active ingredients responsible for these effects. Of the 7 fractions (Fr1-Fr7) prepared from the extract of D. lotus leaves, Fr5 contained the highest phenolic content and exhibited the strongest activity. Five active ingredients of Fr5 were discovered, and 4 of them were identified as myricitrin (Mytr), myricetin (Myt), myricetin-3- O-β-d-glucoside (Myt-Glc), and myricetin-3- O-β-d-galactoside (Myt-Gal). The content of Mytr was much higher than those of the other 3 ingredients, both in Fr5 and extracts of D. lotus leaves. Finally, Mytr and Myt were proved to have stronger activities by the 1,1-diphenyl-2-trinitrophenyl hydrazine scavenging, nitrite scavenging, and inhibition of NAs formation assays. These results indicated that Mytr was the main active ingredient of D. lotus leaves. Myt, Mytr, and Fr5 from the leaves could be used as natural agents for antioxidant, nitrite scavenging, and inhibition of NAs formation in food and the human body.
Collecting Repeated Data Over Time: Applying Experience Sampling Methodology to the Hospitality Management Context
Authors: Yu Heyao , Lee Lindsey , Madera Juan M.
Published: September 2020

While organizational and management research has implemented the use of experience sampling methods (ESM), hospitality management research has yet to reap the benefits of this method and design. ESM involves collecting data at several time points from participants as they experience organizational phenomena, measuring the variations and oscillations in attitudes, behaviors, and performance. This article seeks to define ESM for hospitality research, highlight the strengths, outline the challenges of ESM, and offer best practices by using ESM data from three hospitality industry examples. Each example compares cross-sectional data collection methods and analyses to ESM data collection methods and analyses to compare the different results of the data collection methods.
Does the economics and civic education in Germany prepare future local politicians for a mandate takeover?
Authors: Schuhen Michael , Hundhausen Andreas
Published: September 2020

In the Federal Republic of Germany, the cities and municipalities decide which streets are being refurbished, which educational services are offered, or where sewers will be laid. The cities and municipalities have financial resources at their disposal for this purpose. However, these resources are, with a view to Rhineland-Palatinate, insufficient or inadequate for these versatile tasks. The available financial resources are distributed in the municipal parliaments. The local politicians are elected representatives from the general society. Every citizen over 18 years can be elected in order to decide upon the distribution of funds. Yet, parliamentarians require economic knowledge, and a certain competence in economics matters for these decision-making processes. The aim of this study is to determine the degree to which economics and civil education in Germany is able to qualify future local politicians for a local-political mandate. In this context, it is worthy of note that our respondents ( N = 263) are not able to consider multilevel consequences of context alterations with regard to the finances of their municipality.
Inhibition of viral and bacterial trigger-stimulated prostaglandin E2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line
Authors: Lambkin-Williams Rob , Mann Alex , Shephard Adrian
Published: September 2020

Objectives:

Symptoms of sore throat result from oropharyngeal inflammation, for which prostaglandin E2 is a key mediator. Flurbiprofen is a non-steroidal anti-inflammatory that provides sore throat relief. The preliminary objective of this study was to develop an in vitro model for assessing prostaglandin E2 stimulation by viral and bacterial triggers. The primary objective was to investigate the effect of diluted flurbiprofen-containing lozenges on prostaglandin E2 concentrations in stimulated cells.

Methods:

Prostaglandin E2 production was stimulated in three epithelial cell lines (A549, HEp2, and clonetics bronchial/tracheal epithelial) with influenza A virus (4.5 log10 tissue culture infectious dose50/mL), or bacterial lipopolysaccharide (10µ g/mL) and peptidoglycan (3µ g/mL) and incubated overnight. Prostaglandin E2 levels were assessed by enzyme-linked immunosorbent assay up to 24 h after stimulation. The effect of flurbiprofen 8.75 mg lozenges (diluted to 0.44 mg/mL) on PGE2 production in stimulated cells was assessed in parallel; prior to viral/LPS/PEP stimulation of cells, 300 μL of test product or control was added and incubated for 30 s, 2 and 5 min (and 10 min for bacterial trigger). Prostaglandin E2 levels were measured following stimulation.

Results:

Viral and lipopolysaccharide/peptidoglycan infection did not consistently stimulate HEp2 cells and bronchial/tracheal epithelial cells to produce prostaglandin E2. Influenza virus, and lipopolysaccharide/peptidoglycan stimulated high prostaglandin E2 concentrations in A549: mean prostaglandin E2 concentration 106.48 pg/mL with viral stimulation vs 33.82 pg/mL for uninfected cells; 83.84 pg/mL with lipopolysaccharide/peptidoglycan vs 71.96 pg/mL for uninfected cells. Flurbiprofen produced significant reductions in virus-stimulated prostaglandin E2 vs stimulated untreated cells at 2 min (p = 0.03). Flurbiprofen produced significant reductions in lipopolysaccharide/peptidoglycan-stimulated prostaglandin E2 concentrations from 30 s (p = 0.02), and at 2, 5 and 10 min (all p < 0.005) vs stimulated untreated cells.

Conclusions:

A549 cells provide a suitable model for assessment of prostaglandin E2 stimulation by viral and bacterial triggers. Diluted flurbiprofen-containing lozenges demonstrated rapid anti-inflammatory activity in viral- and lipopolysaccharide/peptidoglycan-stimulated A549 cells.
Novel variants of MEFV and NOD2 genes in familial hidradenitis suppurativa: A case report
Authors: Jfri Abdulhadi , Litvinov Ivan V , Netchiporouk Elena , O’Brien Elizabeth
Published: September 2020

We report a two-generation Canadian family of Armenian ancestry with hidradenitis suppurativa where novel mutations in MEVF and NOD2 genes were identified. The father and both children shared a mild-to-moderate hidradenitis suppurativa phenotype together with the features of follicular occlusion (e.g. acne and scalp folliculitis). Based on our findings and previous literature, we recommend considering genetic testing with a periodic fever/autoinflammatory disorder panel in patients with a strong family history of hidradenitis suppurativa and lack of common triggers such as smoking and being overweight.