bluuebunny/crossref_metadata_2025 huggingface dataset:
Ionic liquid-supported magnetite nanoparticles as electrode modifier materials for estrogens sensing
Authors: Moreira Fernanda , Santana Edson Roberto , Spinelli Almir
Published: February 2020

This paper reports the application of a carbon paste electrode modified with magnetite nanoparticles and the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate in the electroanalytical determination of 17β-estradiol and estriol. These estrogens are potential endocrine disruptors and thus it is relevant the development of devices for their monitoring. Transmission electron microscopy, scanning electron microscopy and zeta potential techniques were applied to characterization of the modifier materials. In cyclic voltammetry experiments, irreversible oxidation peaks were observed for 17β-estradiol and estriol at +0.320 V and +0.400 V, respectively. The anodic currents obtained were approximately three times greater than those provided by the unmodified electrode due to the presence of magnetic nanoparticles and the ionic liquid, which improved the sensitivity of modified electrode. For the analysis, the parameters of the square-wave voltammetry (scan increment, amplitude and frequency) were optimized by Box-Behnken factorial design for each estrogen. For 17β-estradiol in B-R buffer pH 12.0, the calibration plot was linear from 0.10 to 1.0 μmol L−1, with a detection limit of 50.0 nmol L−1. For estriol in B-R buffer pH 11.0, the linear range was 1.0 to 10.0 μmol L−1, with a detection limit of 300.0 nmol L−1. The modified electrode was applied in the determination of 17β-estradiol and estriol in pharmaceutical formulations and the results were comparable to those obtained using UV/VIS spectrometry. Statistical tests were applied to evaluate the results and it was concluded that there was no significant difference regarding the precision and accuracy of the data provided by the two methods.
Effect of the proton irradiation on the thermally activated flux flow in superconducting SmBCO coated conductors
Authors: Choi W. J. , Ahmad D. , Seo Y. I. , Ko R. K. , Kwon Yong Seung
Published: February 2020

We investigate changes in the vortex pinning mechanism caused by proton irradiation through the measurement of the in-plane electrical resistivity for H//c in a pristine and two proton-irradiated (total doses of 1 × 1015 and 1 × 1016 cm−2) SmBa2Cu3O7-δ (SmBCO) superconducting tapes. Even though proton irradiation has no effect on the critical temperature (Tc), the resulting artificial point defect causes an increase in normal state electrical resistivity. The electrical resistivity data around Tc shows no evidence of a phase transition to the vortex glass state but only broadens with increasing magnetic field due to the vortex depinning in the vortex liquid state. The vortex depinning is well interpreted by a thermally activated flux flow model in which the activation energy shows a nonlinear temperature change $${\boldsymbol{U}}{\boldsymbol{(}}{\boldsymbol{T}},{\boldsymbol{H}}{\boldsymbol{)}}{\boldsymbol{=}}{{\boldsymbol{U}}}_{{\boldsymbol{0}}}{\boldsymbol{(}}{\boldsymbol{H}}{\boldsymbol{)}}{{\boldsymbol{(}}{\bf{1}}-{\boldsymbol{T}}{\boldsymbol{/}}{{\boldsymbol{T}}}_{{\boldsymbol{c}}}{\boldsymbol{)}}}^{{\boldsymbol{q}}}$$
U

(

T
,
H

)

=

U

0

(
H
)

(

1

−

T
/

T

c

)

q

(q = 2). The field dependence of activation energy shows a $${{\boldsymbol{U}}}_{{\bf{0}}}{\boldsymbol{ \sim }}{{\boldsymbol{H}}}^{-{\boldsymbol{\alpha }}}$$

U

0

~

H

−
α

with larger exponents above 4 T. This field dependence is mainly due to correlated disorders in pristine sample and artificially created point defects in irradiated samples. Compared with the vortex pinning due to correlated disorders, the vortex pinning due to the appropriate amount of point defects reduces the magnitude of Uo(H) in the low magnetic field region and slowly reduces Uo(H) in high magnetic fields.
Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
Authors: Grönroos Toni , Mäkinen Artturi , Laukkanen Saara , Mehtonen Juha , Nikkilä Atte , Oksa Laura , Rounioja Samuli , Marincevic-Zuniga Yanara , Nordlund Jessica , Pohjolainen Virva , Paavonen Timo , Heinäniemi Merja , Lohi Olli
Published: February 2020

Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.
A 124-plex Microhaplotype Panel Based on Next-generation Sequencing Developed for Forensic Applications
Authors: Pang Jing-Bo , Rao Min , Chen Qing-Feng , Ji An-Quan , Zhang Chi , Kang Ke-Lai , Wu Hao , Ye Jian , Nie Sheng-Jie , Wang Le
Published: February 2020

Microhaplotypes are an emerging type of forensic genetic marker that are expected to support multiple forensic applications. Here, we developed a 124-plex panel for microhaplotype genotyping based on next-generation sequencing (NGS). The panel yielded intralocus and interlocus balanced sequencing data with a high percentage of effective reads. A full genotype was determined with as little as 0.1 ng of input DNA. Parallel mixture experiments and in-depth comparative analyses were performed with capillary-electrophoresis-based short tandem repeat (STR) and NGS-based microhaplotype genotyping, and demonstrated that microhaplotypes are far superior to STRs for mixture deconvolution. DNA from Han Chinese individuals (n = 256) was sequenced with the 124-plex panel. In total, 514 alleles were observed, and the forensic genetic parameters were calculated. A comparison of the forensic parameters for the 20 microhaplotypes with the top Ae values in the 124-plex panel and 20 commonly used forensic STRs showed that these microhaplotypes were as effective as STRs in identifying individuals. A linkage disequilibrium analysis showed that 106 of the 124 microhaplotypes were independently hereditary, and the combined match probability for these 106 microhaplotypes was 5.23 × 10−66. We conclude that this 124-plex microhaplotype panel is a powerful tool for forensic applications.
PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD
Authors: Nowacka Agata , Borczyk Małgorzata , Salamian Ahmad , Wójtowicz Tomasz , Włodarczyk Jakub , Radwanska Kasia
Published: February 2020

PSD-95 is a major scaffolding protein of the post-synaptic density (PSD) of a glutamatergic synapse. PSD-95, via interactions with stargazin, anchors AMPA receptors at the synapse and regulates AMPAR currents. The expression of PSD-95 is regulated during synaptic plasticity. It is, however, unknown whether this regulation is required for induction of functional plasticity of glutamatergic synapses. Here, we show that NMDA-induced long-term depression of synaptic transmission (NMDA-LTD) is accompanied by downregulation of PSD-95 protein levels. Using pharmacologic and molecular manipulations, we further demonstrate that the NMDA-induced downregulation of PSD-95 depends on the activation of CaMKII and CaMKII-driven phosphorylation of PSD-95 serine 73. Surprisingly, neither CaMKII activity nor CaMKII-dependent phosphorylation of PSD-95 serine 73 are required for the expression of NMDA-LTD. These results support the hypothesis that synaptic plasticity of AMPARs may occur without dynamic regulation of PSD-95 protein levels.
Effects of Human Synchronous Hand Movements in Eliciting a Sense of Agency and Ownership
Authors: Hao Qiao , Ora Hiroki , Ogawa Ken-ichiro , Amano Shun-ichi , Miyake Yoshihiro
Published: February 2020

The self is built as an entity independent from the external world using the human ability to experience the senses of agency and ownership. Humans usually experience these senses during movement. Nevertheless, researchers recently reported that another person’s synchronous mirror-symmetrical movements elicited both agency and ownership in research participants. However, it is unclear whether this elicitation was caused by the synchronicity or the mirror symmetry of the movements. To address this question, we investigated the effect of interpersonal synchronization on the self-reported sense of agency and ownership in two conditions, using movements with and without mirror symmetry. Participants performed rhythmic hand movements while viewing the experimenter’s synchronous or random hand movements, and then reported their perceptions of agency and ownership in a questionnaire. We observed that agency and ownership were significantly elicited by the experimenter’s synchronous hand movements in both conditions. The results suggested that the synchronous movements of another person—rather than mirror- or non-mirror-symmetrical movements—appear to elicit the experience of a sense of agency and ownership. The results also suggested that people could experience these senses not only from their own movements but also from another person’s synchronous movements.
Systematic dissection of biases in whole-exome and whole-genome sequencing reveals major determinants of coding sequence coverage
Authors: Barbitoff Yury A. , Polev Dmitrii E. , Glotov Andrey S. , Serebryakova Elena A. , Shcherbakova Irina V. , Kiselev Artem M. , Kostareva Anna A. , Glotov Oleg S. , Predeus Alexander V.
Published: February 2020

Advantages and diagnostic effectiveness of the two most widely used resequencing approaches, whole exome (WES) and whole genome (WGS) sequencing, are often debated. WES dominated large-scale resequencing projects because of lower cost and easier data storage and processing. Rapid development of 3rd generation sequencing methods and novel exome sequencing kits predicate the need for a robust statistical framework allowing informative and easy performance comparison of the emerging methods. In our study we developed a set of statistical tools to systematically assess coverage of coding regions provided by several modern WES platforms, as well as PCR-free WGS. We identified a substantial problem in most previously published comparisons which did not account for mappability limitations of short reads. Using regression analysis and simple machine learning, as well as several novel metrics of coverage evenness, we analyzed the contribution from the major determinants of CDS coverage. Contrary to a common view, most of the observed bias in modern WES stems from mappability limitations of short reads and exome probe design rather than sequence composition. We also identified the ~ 500 kb region of human exome that could not be effectively characterized using short read technology and should receive special attention during variant analysis. Using our novel metrics of sequencing coverage, we identified main determinants of WES and WGS performance. Overall, our study points out avenues for improvement of enrichment-based methods and development of novel approaches that would maximize variant discovery at optimal cost.
Shift work and risk of skin cancer: A systematic review and meta-analysis
Authors: Yousef Einas , Mitwally Noha , Noufal Noha , Tahir Muhammad Ramzan
Published: February 2020

Shift work with circadian disruption has been considered as a carcinogenic risk factor for skin cancer. The few prior studies that investigated the association between shift work and skin cancer have inconclusive results. Our main objective was to evaluate the associations between shift work and the risks of different types of skin cancer. We systematically searched PubMed, Web of Science, Cochrane Library, EMBASE and Science Direct until October 2018 for studies that included a relationship between shift work and skin cancer. Our search yielded 193 articles and 9 studies met the criteria for our review. The included studies involved 3,579,147 participants and 17,308 skin cancer cases. Overall, ever shift work, was associated with increased risk of melanoma (RR = 1.10, 95% CI = 1.05–1.16) and a significant decrease in the risk of BCC (RR = 0.90, 95% CI = 0.88–0.93). No association between shift work and the risk of SCC was detected. Interestingly, our dose response analysis demonstrated that the risk of melanoma cumulatively increases by 2% for every year of shift work (RR = 1.02; 95% CI = 1.00–1.03). In conclusion, shift work is associated with increased risk of melanoma and deceased risk of BCC. Further studies are needed to confirm our findings and to elucidate the related potential biological mechanisms.
Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts
Authors: Cohen Clay T. , Turner Nancy A. , Moake Joel L.
Published: February 2020

Human endothelial cells (ECs) synthesize, store, and secrete von Willebrand factor multimeric strings and coagulation factor (F) VIII. It is not currently known if ECs produce other coagulation factors for active participation in coagulation. We found that 3 different types of human ECs in primary culture produce clotting factors necessary for FX activation via the intrinsic (FVIII-FIX) and extrinsic (tissue factor [TF]-FVII) coagulation pathways, as well as prothrombin. Human dermal fibroblasts were used as comparator cells. TF, FVII, FIX, FX, and prothrombin were detected in ECs, and TF, FVII, FIX, and FX were detected in fibroblasts. In addition, FVII, FIX, FX, and prothrombin were detected by fluorescent microscopy in EC cytoplasm (associated with endoplasmic reticulum and Golgi proteins). FX activation occurred on human umbilical vein EC surfaces without the addition of external coagulation proteins, proteolytic enzymes, or phospholipids. Tumour necrosis factor, which suppresses the generation of activated protein C and increases TF, augmented FX activation. Fibroblasts also produced TF, but (in contrast to ECs) were incapable of activating FX without the exogenous addition of FX and had a marked increase in FX activation following the addition of both FX and FVII. We conclude that human ECs produce their own coagulation factors that can activate cell surface FX without the addition of exogenous proteins or phospholipids.
First isolation and molecular characterization of Toxoplasma gondii strains from human congenital toxoplasmosis cases in Monastir, Tunisia
Authors: Lahmar Ibtissem , Lachkhem Arwa , Babba Oussama , Slama Darine , Trabelsi Aida , Passebosc-Faure Karine , Dardé Marie Laure , Babba Hamouda
Published: February 2020

Toxoplasma gondii is a protozoon parasite that can cause severe clinical problems such as congenital toxoplasmosis. The distribution of T. gondii genotypes varies from one geographic area to another. So far, little is known about the parasite genotypes in Tunisia, North Africa. The present study aimed isolating and genotyping T. gondii from the amniotic fluid (AF) and placenta of pregnant women in Monastir, Tunisia. Amniotic fluid and/or placenta from 80 women who acquired toxoplasma infection during pregnancy were tested by PCR and/or mouse bioassay. Genotyping of T. gondii isolates from these samples was performed with 15 microsatellite markers. Four viable T. gondii strains were isolated from either the AF or placenta of four women. Specifically, strains TUN001-MON1 and TUN002-MON2 were isolated from both the AF and placenta, TUN003-AHA from only the placenta, and TUN004-NEL from only the AF. The four viable strains were not virulent for mice. Genotyping revealed that the four strains were type II strains. This is the first report on isolation and genotyping of T. gondii from AF human samples in Tunisia. Further studies focused on T. gondii genotyping on a larger number of human cases and on animals in Tunisia are needed to improve the knowledge and epidemiology of toxoplasmosis.
Visceral Adipose Tissue Depth in Early Pregnancy and Gestational Diabetes Mellitus - a Cohort Study
Authors: Alves João Guilherme , Souza Alex Sandro Rolland , Figueiroa José Natal , de Araújo Carla Adriane Leal , Guimarães Angélica , Ray Joel Geoffrey
Published: February 2020

Some studies have suggested that abdominal visceral adipose tissue depth (VAD) measured by ultrasound in early pregnancy, may predict the future onset of gestational diabetes mellitus (GDM). Wheter this is true, independent of pre-pregnancy body mass index (BMI), has been debated, leading the current study. A prospective cohort study was completed, in which VAD was measured at around 14 weeks’ gestation. GDM was later assessed by an oral glucose tolerance test at 24 to 28 weeks, according to the IADPSG criteria. Logistic regression analysis and receiver operating curve (ROC) analysis were used to estimate the predictive value of VAD, above and beyond pre-pregnancy BMI. 627 pregnant women were enrolled, and 518 completed the study. VAD was measured at a mean of 14.4 weeks’ gestation. 87 women (16.8%) subsequently developed GDM. The unadjusted odds ratio (OR) for developing GDM was 1.99 (95% CI 1.59–2.46) per 1-cm increase in VAD. After adjusting for maternal BMI and age, the OR was 2.00 (95% CI 1.61 to 2.50). The ROC under the curve for developing GDM was higher for VAD (0.70, 95% CI 0.63 to 0.75) than for pre-pregnancy BMI (0.57 95% CI 0.50 to 0.64) (p < 0.001). In conclusion, higher VAD may better predict GDM than pre-pregnancy BMI.
Author Correction: Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals
Authors: Singh Ashok K. , Bhadauria Archana S. , Kumar Umesh , Raj Vinit , Rai Amit , Kumar Pranesh , Keshari Amit K. , Kumar Dinesh , Maity Biswanath , Nath Sneha , Prakash Anand , Saha Sudipta
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Thermodynamic Signatures of Weyl Fermions in NbP
Authors: Modic K. A. , Meng Tobias , Ronning Filip , Bauer Eric D. , Moll Philip J. W. , Ramshaw B. J.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle
Authors: Abdel-Maksoud Fatma M. , Abd-Elhafeez Hanan H. , Soliman Soha A.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Precision and safety of Multilevel Cervical Transpedicular Screw Fixation with 3D Patient-Specific Guides; A Cadaveric Study
Authors: Sallent Andrea , Ramírez Manuel , Catalá Jordi , Rodríguez-Baeza Alfonso , Bagó Joan , de Albert Matías , Vélez Roberto
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy
Authors: Chu Candice P. , Hokamp Jessica A. , Cianciolo Rachel E. , Dabney Alan R. , Brinkmeyer-Langford Candice , Lees George E. , Nabity Mary B.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Impact of next-generation vehicles on tropospheric ozone estimated by chemical transport model in the Kanto region of Japan
Authors: Hata Hiroo , Tonokura Kenichi
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy
Authors: Pan Peipei , Weisenberger Daniel J. , Zheng Siyu , Wolf Marie , Hwang David G. , Rose-Nussbaumer Jennifer R. , Jurkunas Ula V. , Chan Matilda F.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
An overview of clinical decision support systems: benefits, risks, and strategies for success
Authors: Sutton Reed T. , Pincock David , Baumgart Daniel C. , Sadowski Daniel C. , Fedorak Richard N. , Kroeker Karen I.
Published: February 2020

Computerized clinical decision support systems, or CDSS, represent a paradigm shift in healthcare today. CDSS are used to augment clinicians in their complex decision-making processes. Since their first use in the 1980s, CDSS have seen a rapid evolution. They are now commonly administered through electronic medical records and other computerized clinical workflows, which has been facilitated by increasing global adoption of electronic medical records with advanced capabilities. Despite these advances, there remain unknowns regarding the effect CDSS have on the providers who use them, patient outcomes, and costs. There have been numerous published examples in the past decade(s) of CDSS success stories, but notable setbacks have also shown us that CDSS are not without risks. In this paper, we provide a state-of-the-art overview on the use of clinical decision support systems in medicine, including the different types, current use cases with proven efficacy, common pitfalls, and potential harms. We conclude with evidence-based recommendations for minimizing risk in CDSS design, implementation, evaluation, and maintenance.
Publisher Correction: Conversion of triphenylphosphine oxide to organophosphorus via selective cleavage of C-P, O-P, and C-H bonds with sodium
Authors: Zhang Jian-Qiu , Ye Jingjing , Huang Tianzeng , Shinohara Hiroyuki , Fujino Hiroyoshi , Han Li-Biao
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Labelling primary immune cells using bright blue fluorescent nanoparticles
Authors: Belanger Maura C. , Zhuang Meng , Ball Alexander G. , Richey Kristen H. , DeRosa Christopher A. , Fraser Cassandra L. , Pompano Rebecca R.
Published: February 2020

Using nanoparticles with a bright boron-based fluorescent dye in the core allows for cell tracking across multiple short wavelength excitation sources.
Fluorescence resonance energy transfer (FRET)-based nanoarchitecture for monitoring deubiquitinating enzyme activity
Authors: Liang Yan-Yan , Zhang Jie , Cui Hui , Shao Zhen-Shu , Cheng Chen , Wang Yue-Bo , Wang Huai-Song
Published: February 2020

A novel nanoarchitecture (MSN-Tb-UbR) was prepared by modifying rhodamine B-labelled Ubs (Ub-Rs) on the surface of mesoporous silica nanoparticles (MSNs) loaded with Tb3+-complexes.
Keto–enol tautomerization drives the self-assembly of leucoquinizarin on Au(111)
Authors: Costantini Roberto , Colazzo Luciano , Batini Laura , Stredansky Matus , Mohammed Mohammed S. G. , Achilli Simona , Floreano Luca , Fratesi Guido , de Oteyza Dimas G. , Cossaro Albano
Published: February 2020

Leucoquinizarin is found to assemble on Au(111) surfaces in its keto–enolic tautomeric configuration and to form nanometric porous structures.
Iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids
Authors: Zeng Linwei , Chen Renjie , Zhang Chen , Xie Hujun , Cui Sunliang
Published: February 2020

A mild and efficient iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids has been successfully developed.
Chlorotellurate(iv) supramolecular associates with “trapped” Br2: features of non-covalent halogen⋯halogen interactions in crystalline phases
Authors: Usoltsev Andrey N. , Adonin Sergey A. , Novikov Alexander S. , Abramov Pavel A. , Sokolov Maxim N. , Fedin Vladimir P.
Published: February 2020

Reactions of chlorotellurates(iv) and Br2 afford formation of supramolecular complexes Cat2{[TeCl6](Br2)} (Cat = Me3N+ (1), PyH+ (2), 4-MePyH+ (3) and 1-MePy+ (4)) where dibromine fragments are “trapped” by [TeCl6]3−via Br⋯Cl halogen bonding.
Effects of the cooling rate on the crystallization behaviors of the CaO–Al2O3–B2O3–CaF2-based mold flux
Authors: Li Jiangling , Lai Feifei , Yao Wen , Hu Liwen , Liu Qingcai
Published: February 2020

The effects of the cooling rate on a new type CaO–Al2O3–B2O3–CaF2-based mold flux for high aluminum steel casting were investigated using CSLM and a high temperature tube furnace.
A deeper look into the photocycloreversion of a yellow diarylethene photoswitch: why is it so fast?
Authors: Jarota Arkadiusz , Pastorczak Ewa , Abramczyk Halina
Published: February 2020

The DMT photoswitch features an efficient ring-opening reaction at a sub-picosecond timescale owing to a single-channel relaxation from the S1 state which leads to a conical intersection with the ground state.
Computational approaches to studying methylated H4K20 recognition by DNA repair factor 53BP1
Authors: Li Zhendong , Bao Jingxiao , Qi Yifei , Zhang John Z. H.
Published: February 2020

Structure of H4K20me2–53BP1 complex. (a) H4K20me2 in complex with the tandem Tudor domain of 53BP1 (pdbid 2lvm). (b) and (c) Close-up view of the structure.
Interfacial tension and mechanism of liquid–liquid phase separation in aqueous media
Authors: Titus Amber R. , Ferreira Luisa A. , Belgovskiy Alexander I. , Kooijman Edgar E. , Mann Elizabeth K. , Mann J. Adin , Meyer William V. , Smart Anthony E. , Uversky Vladimir N. , Zaslavsky Boris Y.
Published: February 2020

The organization of multiple subcellular compartments is controlled by liquid–liquid phase separation.
Competition between the heavy atom effect and vibronic coupling in donor–bridge–acceptor organometallics
Authors: Eng Julien , Thompson Stuart , Goodwin Heather , Credgington Dan , Penfold Thomas James
Published: February 2020

The excited state properties and intersystem crossing dynamics of a series of donor–bridge–acceptor carbene metal-amides based upon the coinage metals Cu, Ag, Au, are investigated using quantum dynamics simulations and supported by photophysical characterisation.
Photophysics and photochemistry with Earth-abundant metals – fundamentals and concepts
Authors: Förster Christoph , Heinze Katja
Published: February 2020

This review summarizes fundamental challenges and recent advances in the design of photoactive and luminescent mononuclear transition metal complexes with Earth-abundant metal ions as sustainable alternatives to precious metal ions.
Regeneration of Cu/SAPO-34(MO) with H2O only: too good to be true?
Authors: Woo Jungwon , Bernin Diana , Ahari Homayoun , Shost Mark , Zammit Michael , Olsson Louise
Published: February 2020

Illustration of the proposed mechanism for deactivation and regeneration of Cu/SAPO-34(MO) with H2O.
NH3-Plasma pre-treated carbon supported active iron–nitrogen catalyst for oxygen reduction in acid and alkaline electrolytes
Authors: Mohan Roopathy , Modak Arindam , Schechter Alex
Published: February 2020

A new strategy in the synthesis of M–N–C type catalysts was introduced through the combination of plasma pre-treatment followed by conventional pyrolysis, which demonstrated higher ORR activity and stability than pristine M–N–C catalysts.
Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium
Authors: Adiyala Praveen Reddy , Jang Seungwook , Vishwakarma Niraj K. , Hwang Yoon-Ho , Kim Dong-Pyo
Published: February 2020

Continuous-flow visible-light-induced decarboxylative annulation using a polydimethylsiloxane microreactor containing immobilized Ru3+ has been established for the construction of fused imidazole derivatives.
Visible-light-induced decarboxylative acylation of quinoxalin-2(1H)-ones with α-oxo carboxylic acids under metal-, strong oxidant- and external photocatalyst-free conditions
Authors: Xie Long-Yong , Bai You-Shu , Xu Xiang-Qin , Peng Xia , Tang Hai-Shan , Huang Ying , Lin Ying-Wu , Cao Zhong , He Wei-Min
Published: February 2020

An eco-friendly visible-light-induced decarboxylative acylation of quinoxalin-2(1H)-ones and α-oxo carboxylic acids with air as the oxidant under external-photocatalyst-free conditions was established.
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors
Authors: Wan L. , Neumann C. A. , LeDuc P. R.
Published: February 2020

Tumor progression is significantly influenced by factors such as mechanical force, shear stress, chemotaxis, and hypoxia. Here, we reviewed recent achievements and presented potential directions for tumor-on-a-chip systems in the future.
The effectiveness of filtering glycopeptide peak list files for Y ions
Authors: Chalkley Robert J. , Medzihradszky Katalin F. , Darula Zsuzsanna , Pap Adam , Baker Peter R.
Published: February 2020

Novel software workflow for identifying additional glycopeptides in complex datasets.
Janus coordination polymer derived PdO/ZnO nanoribbons for efficient 4-nitrophenol reduction
Authors: Liu Mufei , Cui Fang , Ma Qinghai , Xu Linxu , Zhang Jiajia , Zhang Ruliang , Cui Tieyu
Published: February 2020

Bimetallic coordination polymers–Zn(MAA)2/Pd(ii) nanoribbons are prepared by employing two terminal units with distinct hard–soft properties of the smallest semi-rigid methacrylate anion to combine with two different metal ions.
A new 3D four-fold interpenetrated dia-like luminescent Zn(ii)-based metal–organic framework: the sensitive detection of Fe3+, Cr2O72−, and CrO42− in water, and nitrobenzene in ethanol
Authors: Xu Tian-Yang , Li Jia-Ming , Han Ya-Hui , Wang Ai-Rong , He Kun-Huan , Shi Zhong-Feng
Published: February 2020

A four-fold interpenetrating Zn-MOF as a multi-responsive fluorescent sensor for Fe3+, Cr2O72−, and CrO42− ions in water, and NB in ethanol is reported.
Metal–organic framework derived petal-like Co3O4@CoNi2S4 hybrid on carbon cloth with enhanced performance for supercapacitors
Authors: Han Dandan , Wei Jinhe , Zhao Yuan , Shen Ye , Pan Yifan , Wei Yen , Mao Liucheng
Published: February 2020

Starting from 2D Co-based metal-organic frameworks, novel petal-like core-shell Co3O4@CoNi2S4 nanowall arrays are synthesized on carbon cloth using a facile two-step method and investigated as promising electrode materials for supercapacitors.
The role of urea in the solubility of cellulose in aqueous quaternary ammonium hydroxide
Authors: Walters Mikayla G. , Mando Albaraa D. , Matthew Reichert W. , West Christy W. , West Kevin N. , Rabideau Brooks D.
Published: February 2020

We examine the role of water and urea in cellulose solubility in tetrabutylammonium hydroxide (TBAH).
Zinc(ii)-based coordination polymer encapsulated Tb3+ as a multi-responsive luminescent sensor for Ru3+, Fe3+, CrO42−, Cr2O72− and MnO4−
Authors: Wu Yuandi , Liu Dongyang , Lin Meihua , Qian Jing
Published: February 2020

A composite, Tb3+@Zn-CP, for sensing Ru3+, Fe3+, CrO42−, Cr2O72− and MnO4− with fast response times was reported.
An alternating multilayer architecture boosts ultrahigh energy density and high discharge efficiency in polymer composites
Authors: Zhang Tao , Dan Zhenkang , Shen Zhonghui , Jiang Jianyong , Guo Mengfan , Chen Bin , Lin Yuanhua , Nan Ce-Wen , Shen Yang
Published: February 2020

Poly(vinylidene fluoride) (PVDF)-based polymers with excellent flexibility and high breakdown strengths are desirable compared to the traditional bulk ceramic in dielectric material applications.
A unimolecular DNA fluorescent probe for determination of copper ions based on click chemistry
Authors: Qin Yingfeng , Li Ming , Yang Yingying , Gao Zhiying , Zhang Huaisheng , Zhao Jingjin
Published: February 2020

A homogenous fluorescence method was constructed for Cu2+ detection by employing DNA-templated click chemistry and exonuclease reaction.
A solid-state integrated photo-supercapacitor based on ZnO nanorod arrays decorated with Ag2S quantum dots as the photoanode and a PEDOT charge storage counter-electrode
Authors: Solís-Cortés D. , Navarrete-Astorga E. , Schrebler R. , Peinado-Pérez J. J. , Martín F. , Ramos-Barrado J. R. , Dalchiele E. A.
Published: February 2020

A new structural configuration of a two electrode photocapacitor using ZnO nanorods decorated with Ag2S quantum dots as photoelectrode.
Pressure effects on sulfide electrolytes for all solid-state batteries
Authors: Doux Jean-Marie , Yang Yangyuchen , Tan Darren H. S. , Nguyen Han , Wu Erik A. , Wang Xuefeng , Banerjee Abhik , Meng Ying Shirley
Published: February 2020

All-solid-state batteries exhibit good performance even at low operating stack pressure when soft electrode materials are used.
Low-temperature interfacial engineering for flexible CsPbI2Br perovskite solar cells with high performance beyond 15%
Authors: Yang Xia , Yang Hanjun , Hu Xiaotian , Li Wenting , Fang Zhimin , Zhang Kaifeng , Huang Rui , Li Jinming , Yang Zhou , Song Yanlin
Published: February 2020

High-efficiency flexible CsPbI2Br PSCs are designed by introducing Al-doped ZnO as an electron-transport layer and tert-butyl cyanoacetate as a hole passivation layer. The optimized PSC exhibits outstanding stability and a champion PCE of 15.08%.
Potentiating bisphosphonate-based coordination complexes to treat osteolytic metastases
Authors: Quiñones Vélez Gabriel , Carmona-Sarabia Lesly , Rodríguez-Silva Waldemar A. , Rivera Raíces Alondra A. , Feliciano Cruz Lorraine , Hu Tony , Peterson Esther , López-Mejías Vilmalí
Published: February 2020

The phase-inversion hydrothermal synthesis of alendronate and Ca(ii) promotes the formation of a coordination complex whose solid-state, stability, particle size and cytotoxicity were assessed and optimized to potentiate its biomedical applications.
A flexible and capsular polypyrrole nanotubular film-based pseudo-capacitive electrode with enhanced capacitive properties enabled by Au nanoparticle doping
Authors: Li Zhenyu , Lei Zhen , Wang Yongbin , Wu Yuanpeng , Guo Meiling , He Yi , Chen Jingyu , Wang Jinfeng
Published: February 2020

The capacitive properties of a polypyrrole nanotubular film-based electrode were significantly enhanced by doping with Au.
Metal oxide resistive memory with a deterministic conduction path
Authors: Lee Sunghwan , Seo Shem , Lim Jinho , Jeon Dasom , Alimkhanuly Batyrbek , Kadyrov Arman , Lee Seunghyun
Published: February 2020

In this study, a Ge–Sb–Te ternary chalcogenide layer that functions as a conductive lead is added to a HfO2-based RRAM layer to improve the memory switching reproducibility and reduce HRS/LRS variations.
Gold and hypervalent iodine(iii): liaisons over a decade for electrophilic functional group transfer reactions
Authors: Banerjee Somsuvra , Bhoyare Vivek W. , Patil Nitin T.
Published: February 2020

Building on mechanistic perspective, the review intends to demonstrate how the uniqueness of Au-catalysts has realized a myriad of electrophilic functional group transfer reactions with the use of hypervalent iodine(iii) reagents over the last decade.
Synthesis, structure, magnetic and luminescence properties of two dysprosium single-molecule magnets based on phenoxide dye ligands
Authors: Long Jérôme , Selikhov Alexander N. , Mamontova Ekaterina , Lyssenko Konstantin A. , Guari Yannick , Larionova Joulia , Trifonov Alexander A.
Published: February 2020

We report two dysprosium complexes based on phenoxide dye ligands and showing slow relaxation of their magnetization.
Correction: Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst
Authors: Jiang Hongshuo , Mao Guijie , Wu Hongfeng , An Qi , Zuo Minghui , Guo Weihao , Xu Chunzhao , Sun Zhizhong , Chu Wenyi
Published: February 2020

Correction for ‘Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst’ by Hongshuo Jiang et al., Green Chem., 2019, 21, 5368–5373.
Modifying the nanostructures of PEDOT:PSS/Ti3C2TX composite hole transport layers for highly efficient polymer solar cells
Authors: Hou Chunli , Yu Huangzhong
Published: February 2020

PEDOT:PSS/Ti3C2TX composite hole transport layers with fine-tuned nanostructures are facilely fabricated, which shows obviously higher efficiency and stability than that of the control device with pure PEDOT:PSS as HTL.
Bonding similarities and differences between Y–Sb–Te and Sc–Sb–Te phase-change memory materials
Authors: Zhou Yuxing , Sun Liang , Zewdie Getasew M. , Mazzarello Riccardo , Deringer Volker L. , Ma Evan , Zhang Wei
Published: February 2020

The bonding contrast between Y–Sb–Te and Sc–Sb–Te phase-change memory materials, rendering the two alloys for different types of memory applications, is clarified through orbital-based chemical bonding analyses and structural similarity kernels.
PUConv: Upsampling convolutional network for point cloud semantic segmentation
Authors: Lu Jian , Cheng Haozhe , Luo Maoxin , Liu Tong , Zhang Kaibing
Published: February 2020

Due to the issue of disorder, it is difficult to directly utilise a 2D convolutional neural networks to process 3D point clouds. Recently, PointNet can directly use 3D point sets as the input of convolutional neural networks and complete the processing of point clouds with multi‐layer perceptron (MLP) and symmetric functions. However, the use of MLP to compute the weight function ignores the problem of non‐uniformity sampling caused by the density of point set data. To address the above problem, based on the PointNet++ structure, a kernel density estimation based method is proposed to calculate the density level of the local point sets region under the optimal bandwidth selection principle, and the density re‐weighting of the weight function is developed to better fit the structure of local point clouds. In addition, the authors utilise the upsampling convolution operation to avoid duplicate storages and calculations, making the point cloud reconstruction more efficient. The experiments carried out the semantic segmentation on both the synthetic data and the real indoor scenes show that the proposed method is capable of obtaining promising semantic segmentation results.
Enhancement of axial ratio‐beamwidth of X‐band composite microstrip patch antenna with conical ground plane
Authors: Narke S. , Ananthakrishnan S. , Bhattacharya C.
Published: February 2020

A single‐feed circularly polarised (CP) composite microstrip patch antenna (MPA) with a 3D conical ground plane at X‐band is presented here to meet the requirements of wide beamwidth for on‐board antenna structures of highly rotating bodies in projectile motion. The results of the measurement for fabricated antenna in the anechoic chamber show that a half power beamwidth and axial ratio (AR) beamwidth are achieved for right‐hand CP radiation pattern in both the xoz and yoz planes with a gain of . The AR at the resonating frequency of 10.28 GHz has a low figure of 0.46 dB producing nearly smooth CP foot print with a wide AR beamwidth. The measured reflection coefficient () of CP–MPA is at 10.28 GHz with an impedance bandwidth that is 8.75% of the resonant frequency. The figure of merit for cross‐polarisation in the fabrication is , i.e. achieved at the zenith of co‐polarisation.
Voltage‐mode hysteretic control techniques for high‐current single‐inductor multiple‐output switching regulators
Authors: Huang Cheng , Lee Sangwon
Published: February 2020

In this Letter, two comparator‐based voltage‐mode hysteretic controller designs are proposed to enhance dynamic response for single‐inductor multiple‐output (SIMO) switching converters to minimise over‐/under‐shoot voltages due to self‐ and cross‐regulations in fast load transients, especially with high output power and large current steps. The proposed converters are designed and simulated in a 65 nm CMOS process with standard I/O devices. With the proposed techniques, the output voltage fluctuations, including steady‐state voltage ripples and over‐/under‐shoot voltages due to self‐ and cross‐regulations during a 1.8 A load transient in 1 ns, are kept within 60 mV. The proposed converter delivers more than 3 A maximum load current per output and a maximum total output power above 6 W, with a peak efficiency above 90%. Compared to state‐of‐the‐art SIMO converters, this work achieves a significantly higher output power capacity and faster dynamic response thus smaller self‐ and cross‐regulations within 0.033 mV/mA.
Twice fine‐tuning deep neural networks for paraphrase identification
Authors: Ko Bowon , Choi Ho‐Jin
Published: February 2020

In this Letter, the authors introduce a novel approach to learn representations for sentence‐level paraphrase identification (PI) using BERT and ten natural language processing tasks. Their method trains an unsupervised model called BERT with two different tasks to detect whether two sentences are in paraphrase relation or not. Unlike conventional BERT, which fine tunes the target task such as PI to pre‐trained BERT, twice fine‐tuning deep neural networks first fine tune each task (e.g. general language understanding evaluation tasks, question answering, and paraphrase adversaries from word scrambling task) and second fine tune target PI task. As a result, the multi‐fine‐tuned BERT model outperformed the fine‐tuned model only with Microsoft Research Paraphrase Corpus (MRPC), which is paraphrase data, except for one case of Stanford Sentiment Treebank ‐ 2 (SST‐2). Multi‐task fine‐tuning is a simple idea but experimentally powerful. Experiments show that fine‐tuning just PI tasks to the BERT already gives enough performance, but additionally, fine‐tuning similar tasks can affect performance (3.4% point absolute improvement) and be competitive with the state‐of‐the‐art systems.
A multiplicity study of transiting exoplanet host stars
Authors: Bohn A. J. , Southworth J. , Ginski C. , Kenworthy M. A. , Maxted P. F. L. , Evans D. F.
Published: February 2020

Context. Many main-sequence stars are part of multiple systems. The effect of stellar multiplicity on planet formation and migration, however, is poorly understood.

Aims. We study the multiplicity of stars hosting known transiting extra-solar planets to test competing theories on the formation mechanisms of hot Jupiters.

Methods. We observed 45 exoplanet host stars using the infrared dual imaging spectrograph of the Spectro-Polarimetric High-Contrast Exoplanet Research (SPHERE) instrument at the Very Large Telescope to search for potential companions. For each identified candidate companion we determined the probability that it is gravitationally bound to its host by performing common proper motion checks and modelling of synthetic stellar populations around the host. In addition, we derived contrast limits as a function of angular separation to set upper limits on further companions in these systems. We converted the derived contrast into mass thresholds using AMES-Cond, AMES-Dusty, and BT-Settl models.

Results. We detected new candidate companions around K2-38, WASP-72, WASP-80, WASP-87, WASP-88, WASP-108, WASP-118, WASP-120, WASP-122, WASP123, WASP-130, WASP-131, and WASP-137. The closest candidates were detected at separations of 0.′′124±0.′′007 and 0.′′189±0.′′003 around WASP-108 and WASP-131; the measured K-band contrasts indicate that these are stellar companions of 0.35 ± 0.02 M⊙ and 0.62−0.04+0.05 M⊙, respectively. Including the re-detection and confirmation of previously known companions in 13 other systems, we derived a multiplicity fraction of 55.4−9.4+5.9%. For the representative sub-sample of 40 hot Jupiter host stars among our targets, the derived multiplicity rate is 54.8−9.9+6.3%. Our data do not confirm any trend that systems with eccentric planetary companions are preferably part of multiple systems. On average, we reached a magnitude contrast of 8.5 ± 0.9 mag at an angular separation of 0.′′5. This allows us to exclude additional stellar companions with masses higher than 0.08M⊙ for almost all observed systems; around the closest and youngest systems, this sensitivity is achieved at physical separations as small as 10 au.

Conclusions. Our study shows that SPHERE is an ideal instrument for detecting and characterising close companions to exoplanetary host stars. Although the second data release of the Gaia mission also provides useful constraints for some of the systems, the achieved sensitivity provided by the current data release of this mission is not good enough to measure parallaxes and proper motions for all detected candidates. For 14 identified companion candidates further astrometric epochs are required to confirm their common proper motion at 5σ significance.
Lösungsmöglichkeiten bei fehlgeschlagenen Osteosynthesen an Schulter und Schultergürtel
Authors: Plecko Michael
Published: February 2020

Die Behandlung von fehlgeschlagenen Osteosynthesen an Schulter und Schultergürtel stellt oft eine große Herausforderung an das Behandlungsteam dar. Am häufigsten gibt es Fehlschläge am proximalen Humerus und am Schlüsselbein, die eine auf den Einzelfall abgestimmte individuelle Behandlung erfordern. Neben der konservativen symptomorientierten Therapie sind in manchen Fällen die Reosteosynthese mit oder ohne Knochenaugmentation bzw. Spongiosaplastik oder der endoprothetische Ersatz zu bevorzugen. Wichtig für die Erzielung eines guten Ergebnisses ist neben einer exakten Ursachenanalyse ein frühzeitiges Einschreiten, um Vernarbungen, Kontrakturen bzw. fortgeschrittene Muskelatrophien zu vermeiden. Bei adäquater rechtzeitiger Therapie kann i. d. R. ein zufriedenstellendes Ergebnis erzielt werden.
Destabilization of FoxM1 and Inhibition of Topoisomerase I Contribute to Cytotoxicity of Prenylated Xanthones Isolated from Metaxya rostrata
Authors: Mittermair Eva , Schueffl Hemma , Heffeter Petra , Krenn Liselotte , Marian Brigitte
Published: February 2020

We recently isolated the prenylated xanthones 2-deprenyl-rheediaxanthone B (XB) and 2-deprenyl-7-hydroxy-rheediaxanthone B (OH-XB) from the South American tree fern Metaxya rostrata. This study explores the mechanisms underlying the FoxM1 downregulation induced by both xanthones. Analysis of cell viability and cell-death induction in SW480, HCT116, Caco-2, DLD1 and HT29 exposed to xanthones found cell-loss and activation of caspase in all cell lines except HT29 that do not have high FoxM1 protein levels. To determine the cellular mechanism of xanthone-induced FoxM1 loss, protein stability was analyzed by cycloheximide-chase experiments and showed reduction of FoxM1 stability by XB but not OH-XB. Destabilization was prevented by inhibiting proteasome activity using MG-132 and moderately by the lysosomal inhibitor bafilomycin A1 (baf A1). OH-XB had a stronger impact than XB on FoxM1 mRNA expression by qRT-PCR, and MG-132 positively affected FoxM1 protein level in
OH-XB exposed cells even though no decrease in protein abundance had been induced by the xanthone. Additionally, the compound inhibited topoisomerase I causing DNA DSB and early cell cycle arrest. This may reduce FoxM1 gene expression, which may in turn compromise DNA repair and enhance xanthone-induced cell death. With regard to xanthone-induced cell death, MG-132 protected cultures from cell loss induced by both compounds, and baf A1 was active against these XB-induced effects. In summary, both destabilization of FoxM1 protein and topoisomerase I inhibition contribute to both XB and OH-XB cytotoxic activity albeit at different ratios.
One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imi­dazo[1,2-a]indoles
Authors: Zhou Bingwei , Liu Yunkui , Jin Hongwei , Liu Daohong
Published: February 2020

A copper-catalyzed multicomponent reaction of sulfonyl azides, alkynes, and allylamines affording 2,3-dihydro-1H-imidazo-[1,2-a]indoles in moderate yields is reported. Four C–N bonds are constructed­ by way of azide-alkyne cycloaddition (CuAAC) and double Ullmann-type coupling reactions in a one-pot process.