bluuebunny/crossref_metadata_2025 huggingface dataset:
Relation between Polygenic Risk Score, Vitamin D Status and BMI-for-Age z Score in Chinese Preschool Children
Authors: Peng Luolan , Liu Tingting , Han Chao , Shi Lili , Chen Chen , Zhao Jinpeng , Feng Jing , Wang Mengyao , Zhuo Qin , Huo Junsheng , Li Yan , Gong Zhaolong
Published: March 2024

Background: Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age z score (zBMI) in Chinese preschool children. Methods: A total of 1046 participants aged 3.7 to 6.6 years old from the Long-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack (LHEAPITNP) were included in this study. The polygenic risk score (PRS) was established based on 55 BMI-related single nucleotide polymorphisms (SNPs) derived from a published genome-wide association study (GWAS) for BMI. Serum 25(OH)D was used as an index of vitamin D status and measured with liquid chromatography-tandem mass spectrometry (LC/MS-MS) assay. The Wilcoxon test or Kruskal–Wallis test was used to compare the differences of variables between different groups and Spearman correlation analysis was used for analyzing the correlations between the PRS, 25(OH)D levels, and zBMI. Results: The PRS showed a positive relation to zBMI (rs = 0.0953, p = 0.0022) and 25(OH)D showed a negative relation to zBMI (rs = −0.1082, p = 0.0005) in the full-adjustment model. In addition, the differences in zBMI at different vitamin D statuses in the low-risk PRS group and the intermediate-risk PRS group were both statistically significant (plow = 0.0308, pintermediate = 0.0121), the median zBMI was both higher at vitamin D insufficiency status. And the difference in zBMI between different genetic risk groups was also statistically significant at vitamin D sufficiency status (p = 0.0077). Furthermore, genetic risk showed a positive relation to zBMI at vitamin D sufficiency status, and the p for trend was 0.0028. Conclusions: Our findings suggested that vitamin D was related to zBMI negatively in Chinese preschoolers and maintaining adequate vitamin D levels may only contribute to lower the zBMI in preschoolers with low and intermediate genetic susceptibility.
The Impact of Education Level on Weight Loss in a Primary Care-Anchored eHealth Lifestyle Coaching Program in Denmark: A Randomized Controlled Trial
Authors: Shahin Luma , Olesen Thomas Bastholm , Olsen Michael Hecht , Laursen Ditte Hjorth , Christensen Jeanette Reffstrup , Brandt Carl J.
Published: March 2024

In a randomized controlled trial including 340 people living with obesity, with and without type 2 diabetes, digital coaching has induced significant long-term weight loss compared to the usual methods of care. We investigated whether education level influenced this weight loss and which lifestyle changes supported the digital lifestyle coaching program. The intervention consisted of a 1 h face-to-face motivational interview followed by digital coaching using behavioral change techniques. At 6 months, the weight loss in the intervention group was significantly larger in participants with short education (6.0 vs. 2.2 kg, p < 0.01) (p = 0.006). Participants with long education experienced initially a modest weight loss, but the effect was maintained, leading to the largest weight loss at 24 months (5.06 [−11.98–1.86] kg), even though there were fewer coaching sessions in the maintenance period. In multiple regression analyses, the greater weight loss in the intervention group was associated with short education (β = 1.81, p = 0.02), improvements in everyday physical activity (β = 2.60, p = 0.014) and improvements in dietary habits (β = 3.84, p = 0.013). In conclusion, at 6 months, the effect of the intervention was more pronounced in people with short education through improvements in everyday physical activity and dietary habits. However, participants with long education sustained their weight loss at 24 months.
Unveiling the Dual Threat: How Microbial Infections and Healthcare Deficiencies Fuel Cervical and Prostate Cancer Deaths in Africa
Authors: Abdul-Nasir Sofian , Lee Hyungdon , Rahman Md. Habibur , Bajgai Johny , Lee Kyu-Jae , Kim Cheol-Su , Kim Soo-Ki
Published: March 2024

Cervical and prostate cancer account for 7.1 and 7.3 deaths per 100,000 people globally in 2022. These rates increased significantly to 17.6 and 17.3 in Africa, respectively, making them the second and third leading cause of cancer deaths in Africa, only surpassed by breast cancer. The human papillomavirus is the prime risk factor for cervical cancer infection. On the other hand, prostate cancer risks include ageing, genetics, race, geography, and family history. However, these factors alone cannot account for the high mortality rate in Africa, which is more than twice the global mortality rate for the two cancers. We searched PubMed, Embase, Scopus, and Web of Science to select relevant articles using keywords related to microorganisms involved in cervical and prostate cancer and the impact of poor healthcare systems on the mortality rates of these two cancers in Africa by carrying out a detailed synopsis of the studies on microbial agents involved and the contributory factors to the deteriorating healthcare system in Africa. It became apparent that the developed countries come first in terms of the prevalence of cervical and prostate cancer. However, more people per capita in Africa die from these cancers as compared to other continents. Also, microbial infections (bacterial or viral), especially sexually transmitted infections, cause inflammation, which triggers the pathogenesis and progression of these cancers among the African population; this has been linked to the region’s deficient health infrastructure, making it difficult for people with microbial infections to access healthcare and hence making infection control and prevention challenging. Taken together, untreated microbial infections, primarily sexually transmitted infections due to the deficient healthcare systems in Africa, are responsible for the high mortality rate of cervical and prostate cancer.
Effect of Acute Ketamine Treatment on Sympathetic Regulation Indexed by Electrodermal Activity in Adolescent Major Depression
Authors: Kovacova Veronika , Macejova Andrea , Tonhajzerova Ingrid , Visnovcova Zuzana , Ferencova Nikola , Mlyncekova Zuzana , Kukucka Tomas , Farsky Ivan , Nosal Slavomir , Ondrejka Igor
Published: March 2024

Ketamine is a potential rapid-onset antidepressant characterized by sympathomimetic effects. However, the question of ketamine’s use in treating adolescents’ major depressive disorder (MDD) is still discussed. Thus, we aimed to study the acute effect of ketamine infusion treatment on sympathetic regulation using electrodermal activity (EDA) in addition to an assessment of depressive symptomatology in MDD adolescents. Twenty hospitalized adolescent girls with MDD (average age: 15.0 ± 1.46 yrs.) were examined before and two hours after a single intravenous infusion of ketamine. EDA was continuously recorded for 6 min, and depressive symptoms were assessed before and two hours after ketamine administration. The evaluated parameters included skin conductance level (SCL), nonspecific electrodermal responses (NS-SCRs), MADRS (questions no. 1–10, total score), and CDI (items A–E, total score). EDA parameters showed no significant changes after the ketamine treatment, and depressive symptoms were significantly reduced after the ketamine infusion. The analysis revealed a significant negative correlation between index SCL and CDI-A, CDI-E, and the total CDI score and between index NS-SCRs and MADRS no. 4 before the ketamine treatment. In conclusion, ketamine improved depressive symptomatology without a significant effect on EDA, indicating its potential safety and efficiency as an acute antidepressant intervention in adolescent MDD.
Five-Membered Nitrogen Heterocycles Angiotensin-Converting Enzyme (ACE) Inhibitors Induced Angioedema: An Underdiagnosed Condition
Authors: Papapostolou Niki , Gregoriou Stamatios , Katoulis Alexander , Makris Michael
Published: March 2024

Angiotensin-converting enzyme (ACE) inhibitors are used primarily in the treatment of hypertension, heart failure, and in the acute phase of myocardial infarction. Lisinopril [N2-[(1S)-1-car-boxy-3-phenylpropyl]-L-lysyl-L-proline], enalapril [(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline] and ramipril [2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid] are all five-membered heterocycles and three of the most prevalent ACE inhibitors in clinical use worldwide. ACE inhibitor-induced angioedema (AE) is clinically characterized by self-limited edema of the dermis and subcutaneous lipid tissue, localized on face skin, oral mucosa and tongue in most cases. However, severe episodes of intestinal AE misdiagnosed as acute appendicitis and laryngeal AE requiring incubation have been reported. The pathophysiology of ACE inhibitor-induced angioedema is attributed to the accumulation of bradykinin, which is a potent vasodilator with proinflammatory activity that is normally degraded by angiotensin-converting enzyme (ACE) and aminopeptidase P; however, a small proportion of treated patients is affected. Given that patients do not respond to anti-H1 antihistamines and steroids, early clinical recognition and discontinuation of the ACE inhibitors are the treatments of choice for the long-term management of ACE inhibitor- induced angioedema. The search period of the present review was set up until November 2023, and its aim is to shed light on the broader context of ACE inhibitor-induced angioedema, exploring aspects such as clinical presentation, pathophysiology, and therapeutic considerations in this potentially life-threatening condition. The exploration of alternative drug options such as angiotensin II receptor blockers, the potential association of coadministration of DPP-4 inhibitors with ACE inhibitors, the presentation of angioedema and the significant clinical importance of this condition are also discussed. By focusing on the chemical structure of ACE inhibitors, specifically their nitrogen-based heterocycles—an attribute shared by over 880 drugs approved by the FDA within the pharmaceutical industry—this review emphasizes the pivotal role of nitrogen scaffolds in drug design and underscores their relevance in ACE inhibitor pharmacology.
Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde
Authors: Olayiwola Yusuff , Gollahon Lauren
Published: March 2024

Globally, breast cancer is not only the most frequently diagnosed cancer but also the leading cause of cancer death in women. Depending on breast cancer histotype, conventional breast cancer treatment options vary greatly in efficacy and accompanying side effects. Thus, there is a need for more effective and safer strategies that impact breast cancer at all stages. Plant-based natural products are easily available, with them proving effective and inexpensive. Two such phytochemicals are chlorogenic acid and cinnamaldehyde. Studies have shown their efficacy against different molecular subtypes of breast cancers in vitro and in vivo. In this review, we discuss their current status in anticancer research with specific emphasis on chlorogenic acid and cinnamaldehyde. We describe their multiple mechanisms of action in destroying breast cancer cells, their potential uses, and the need for translational applications. We also include future directions for investigations to progress chlorogenic acid and cinnamaldehyde research from bench to bedside.
Enhanced Skin Permeation of 5-Fluorouracil through Drug-in-Adhesive Topical Patches
Authors: Kim Sangseo , Youssef Souha H. , Lee Kyung Min Kirsten , Song Yunmei , Vaidya Sachin , Garg Sanjay
Published: March 2024

5-fluorouracil (5-FU), commercially available as a topical product, is approved for non-melanoma skin cancer (NMSC) treatment with several clinical limitations. This work aimed to develop 5-FU-loaded topical patches as a potential alternative to overcome such drawbacks. The patches offer accurate dosing, controlled drug release and improved patient compliance. Our study highlights the development of Eudragit® E (EuE)-based drug-in-adhesive (DIA) patches containing a clinically significant high level of 5-FU (approximately 450 µg/cm2) formulated with various chemical permeation enhancers. The patches containing Transcutol® (Patch-TRAN) or oleic acid (Patch-OA) demonstrated significantly higher skin penetration ex vivo than their control counterpart, reaching 5-FU concentrations of 76.39 ± 27.7 µg/cm2 and 82.56 ± 8.2 µg/cm2, respectively. Furthermore, the findings from in vitro permeation studies also validated the superior skin permeation of 5-FU achieved by Patch-OA and Patch-TRAN over 72 h. Moreover, the EuE-based DIA patch platform demonstrated suitable adhesive and mechanical properties with an excellent safety profile evaluated through an inaugural in vivo human study involving 11 healthy volunteers. In conclusion, the DIA patches could be a novel alternative option for NMSC as the patches effectively deliver 5-FU into the dermis layer and receptor compartment ex vivo for an extended period with excellent mechanical and safety profiles.
Metformin-Mediated Improvement in Solubility, Stability, and Permeability of Nonsteroidal Anti-Inflammatory Drugs
Authors: An Qi , Xing Cheng , Wang Zhipeng , Li Shuang , Wang Wenwen , Yang Shiying , Kong Linglei , Yang Dezhi , Zhang Li , Du Guanhua , Lu Yang
Published: March 2024

Nonsteroidal anti-inflammatory drugs (NSAIDs) are class II biopharmaceutics classification system drugs. The poor aqueous solubility of NSAIDs can lead to limited bioavailability after oral administration. Metformin (MET), a small-molecule compound, can be used in crystal engineering to modulate the physicochemical properties of drugs and to improve the bioavailability of orally administered drugs, according to the literature research and preliminary studies. We synthesized two drug–drug molecular salts (ketoprofen–metformin and phenylbutazone–metformin) with NSAIDs and thoroughly characterized them using SCXRD, PXRD, DSC, and IR analysis to improve the poor solubility of NSAIDs. In vitro evaluation studies revealed that the thermal stability and solubility of NSAIDs-MET were substantially enhanced compared with those of NSAIDs alone. Unexpectedly, an additional increase in permeability was observed. Since the structure determines the properties, the structure was analyzed using theoretical calculations to reveal the intermolecular interactions and to explain the reason for the change in properties. The salt formation of NSAIDs with MET could substantially increase the bio-absorption rate of NSAIDs, according to the in vivo pharmacokinetic findings, which provides an experimental basis for developing new antipyretic and analgesic drugs with rapid onset of action.
A New Algorithm Integrating Molecular Response, Toxicity, and Plasma Level Measures for Ponatinib Dose Choice in Patients Affected by Chronic Myeloid Leukemia
Authors: Galimberti Sara , Abruzzese Elisabetta , Luci Giacomo , Baratè Claudia , Luciano Luigia , Iurlo Alessandra , Caocci Giovanni , Morganti Riccardo , Stefanelli Fabio , Di Paolo Antonello
Published: March 2024

Ponatinib may be effective in chronic myeloid leukemia (CML) patients after failure of first/second line therapies. Although its efficacy for minimum plasma concentrations (Cmin) is >21.3 ng/mL (equal to 40 nM), ponatinib may cause adverse events (AE) that require dose optimization. The present study was aimed at investigating any possible correlations among ponatinib dose, plasma concentration, molecular response (MR), and tolerability in a real-world setting. Clinical and laboratory records (including MR and drug plasma concentrations) of 32 CML patients treated with ponatinib were harvested and analyzed. Twenty-seven patients (71%) had ponatinib Cmin values > 21.3 ng/mL, but Cmin values > 10.7 ng/mL (considered efficacious in BCR-Abl unmutated patients) were achieved by 80% of the patients receiving ≥30 mg/day and 45% of the subjects treated with 15 mg/day. No significant correlations were identified among clinical efficacy, tolerability, daily dose, and plasma concentration. Notably, patients who underwent dose tapering for tolerability or safety reasons did not experience treatment failure. In a real-world setting, adjustment of ponatinib daily doses lower than those registered may maintain therapeutic efficacy while reducing the risk of vascular events and improving tolerability. Further studies are warranted to confirm the present results in a larger cohort of patients.
Weekly Oral Tenofovir Alafenamide Protects Macaques from Vaginal and Rectal Simian HIV Infection
Authors: Massud Ivana , Nishiura Kenji , Ruone Susan , Holder Angela , Dinh Chuong , Lipscomb Jonathan , Mitchell James , Khalil George M. , Heneine Walid , Garcίa-Lerma J. Gerardo , Dobard Charles W.
Published: March 2024

Pre-exposure prophylaxis (PrEP) with a weekly oral regimen of antiretroviral drugs could be a suitable preventative option for individuals who struggle with daily PrEP or prefer not to use long-acting injectables. We assessed in macaques the efficacy of weekly oral tenofovir alafenamide (TAF) at doses of 13.7 or 27.4 mg/kg. Macaques received weekly oral TAF for six weeks and were exposed twice-weekly to SHIV vaginally or rectally on day 3 and 6 after each dose. Median TFV-DP levels in PBMCs following the 13.7 mg/kg dose were 3110 and 1137 fmols/106 cells on day 3 and 6, respectively. With the 27.4 mg/kg dose, TFV-DP levels were increased (~2-fold) on day 3 and 6 (6095 and 3290 fmols/106 cells, respectively). Both TAF doses (13.7 and 27.4 mg/kg) conferred high efficacy (94.1% and 93.9%, respectively) against vaginal SHIV infection. Efficacy of the 27.4 mg/kg dose against rectal SHIV infection was 80.7%. We estimate that macaque doses of 13.7 and 27.4 mg/kg are equivalent to approximately 230 and 450 mg of TAF in humans, respectively. Our findings demonstrate the effectiveness of a weekly oral PrEP regimen and suggest that a clinically achievable oral TAF dose could be a promising option for non-daily PrEP.
A Theoretical Investigation of an Ultrawide S-, C- and L-Band-Tunable Random Fiber Laser Based on the Combination of Tellurite Fiber and Erbium-Doped Fiber
Authors: Chen Lu , Li Yang , Liang Houkun , Wu Han
Published: March 2024

In this paper, we present a new scheme to generate ultrawide tunable random fiber lasers (RFLs) covering the S-, C- and L-band by combining the broadband Raman gain in tellurite fibers and the active gain in erbium-doped fibers. A numerical simulation based on the power-balance model is conducted to verify the feasibility of the ultrawide tunable random fiber lasing generation. Pumped by a 1450 nm laser, the tunable random Raman fiber laser in the ranges of 1480–1560 nm and 1590–1640 nm can only be realized with a tellurite fiber. To further fill in the emission gap in the range of 1560–1590 nm, the erbium-doped fiber is incorporated in the cavity, which can provide efficient erbium-doped gain in the C- and L-band. By combining a 100 m long tellurite fiber and an 8 m long erbium-doped fiber, an ultrawide tunable RFL based on hybrid erbium–Raman gain can be realized with a wavelength tuning range (1480 nm–1640 nm) covering the S-, C- and L-band at 3.5 W pump power. Such a widely tunable RFL is of great importance in applications such as optical communication, sensing and imaging.
Physiological Responses of a Grapefruit Orchard to Irrigation with Desalinated Seawater
Authors: Navarro Josefa M. , Imbernón-Mulero Alberto , Robles Juan M. , Hernández-Ballester Francisco M. , Antolinos Vera , Gallego-Elvira Belén , Maestre-Valero José F.
Published: March 2024

Desalinated seawater (DSW) has emerged as a promising solution for irrigation in regions facing water scarcity. However, adopting DSW may impact the existing cultivation model, given the presence of potentially harmful elements, among other factors. A three-year experiment was carried out to assess the short-term effects of four irrigation waters—freshwater (FW), DSW, a mix 1:1 of FW and DSW (MW), and DSW with low boron (B) concentration (DSW–B)—on a ‘Rio Red’ grapefruit orchard. These irrigation waters exhibited varying levels of phytotoxic elements, some potentially harmful to citrus trees. Sodium (Na+) and chloride (Cl−) concentrations exceeded citrus thresholds in all treatments, except in DSW−B, whilst B exceeded toxicity levels in DSW and MW treatments. Leaf concentrations of Cl− and Na+ remained low in all treatments, whereas B approached toxic levels only in DSW and MW–irrigated trees. The rapid growth of the trees, preventing excessive accumulation through a dilution effect, protected the plants from significant impacts on nutrition and physiology, such as gas exchange and chlorophyll levels, due to phytotoxic elements accumulation. Minor reductions in photosynthesis in DSW–irrigated trees were attributed to high B in leaves, since Cl− and Na+ remained below toxic levels. The accelerated tree growth effectively prevented the substantial accumulation of phytotoxic elements, thereby limiting adverse effects on tree development and yield. When the maturation of trees reaches maximal growth, the potential accumulation of phytotoxic elements is expected to increase, potentially influencing tree behavior differently. Further study until the trees reach maturity is imperative for comprehensive understanding of the long-term effects of desalinated seawater irrigation.
Function of FT in Flowering Induction in Two Camellia Species
Authors: Wang Xiong , Li Jiyuan , Yin Hengfu , Li Xinlei , Liu Weixin , Fan Zhengqi
Published: March 2024

FLOWERING LOCUS T (FT), belonging to the FT/TFL1 gene family, is an important gene regulating the flowering transition and inflorescence architecture during plant development. Given its importance to plant adaptation and crop improvement, FT has been extensively studied in related plant research; however, the specific role and underlying molecular mechanisms of FT in the continuous flowering of perennial plants remains elusive. Here, we isolated and characterized homologous FT genes from two Camellia species with different flowering-period phenotypes: CaFT was isolated from Camellia azalea, a precious species blooming in summer and flowering throughout the year, and CjFT was isolated from C. japonica, which blooms in winter and spring. The major difference in the genes between the two species was an additional five-amino acid repeat sequence in C. japonica. FT showed high expression levels in the leaves in both species from January to August, especially in April for C. japonica and in May for C. azalea. CaFT was expressed throughout the year in C. azalea, whereas CjFT was not expressed from September to December in C. japonica. The expression levels of FT in the floral buds were generally higher than those in the leaves. Overexpression of CaFT and CjFT in Arabidopsis indicated that both genes can activate downstream genes to promote flowering. Transgenic callus tissue was obtained by introducing the two genes into C. azalea through Agrobacterium-mediated transformation. Transcriptome and quantitative real-time polymerase chain reaction analyses indicated that both florigen FT genes promoted the expression of downstream genes such as AP1, FUL, and SEP3, and slightly up-regulated the expression of upstream genes such as CO and GI. The above results indicated that CaFT and CjFT played a role in promoting flowering in both camellia species. The expression pattern of CaFT in leaves suggested that, compared to CjFT, CaFT may be related to the annual flowering of C. azalea.
Biochemical Characterization of the Seed Quality of a Collection of White Lupin Landraces from Southern Italy
Authors: Spina Alfio , De Benedetti Stefano , Heinzl Giuditta Carlotta , Ceravolo Giulia , Magni Chiara , Emide Davide , Castorina Giulia , Consonni Gabriella , Canale Michele , Scarafoni Alessio
Published: March 2024

Lupin species provide essential nutrients and bioactive compounds. Within pulses, they have one of the highest contents of proteins and fibers and are among the poorest in carbohydrates. The Mediterranean region is an important cradle area of the origin and domestication of cultivated white lupin (Lupinus albus L.). In this work, we present the characterization of 19 white lupin landraces collected from several sites in southern Italy, characterized by different pedoclimatic conditions. The protein contents and electrophoretic patterns, total polyphenols, phytic acid, lipids and phosphorous content, and reducing and anti-tryptic activities have been determined for each landrace. The relationships of the compositional characteristics, the area of origin of landraces and between compositional characteristics and thermo-pluviometric trends that occurred in the genotype comparison field during the two-year period between 2019 and 2020 are compared and discussed. From a nutritional point of view, some of the analyzed landraces differ from the commercial reference. The panel of molecular analyses performed can help in building an identity card for the grain to rapidly identify those varieties with the desired characteristics.
Analysis of the Anisotropy of Sound Propagation Velocity in Thin Wooden Plates Using Lamb Waves
Authors: Faktorová Dagmar , Stanciu Mariana Domnica , Krbata Michal , Savin Adriana , Kohutiar Marcel , Chlada Milan , Năstac Silviu Marian
Published: March 2024

The objective of the study was to analyze the influence of coating treatments on sound propagation speeds in thin boards, along the longitudinal and radial directions of resonance wood. The samples studied were thin boards made of spruce and maple wood with dimensions of 240 mm × 80 mm × 4 mm (length × width × thickness) subjected to different coating treatments (oil-based varnish and alcohol varnish) as well as unvarnished samples, exposed to radiation UV, and specimens treated in the saline fog. The test method consisted of evaluating the propagation speeds of Lamb waves applied to thin plates, according to a semicircular test model, so that the results highlighted both the acoustic response in the longitudinal and radial directions as well as the variation in the anisotropy of the samples with the change in the sound propagation direction relative to wood fibers. Based on the statistical analysis, sound propagation speed profiles were obtained in each of the 38 directions analyzed for all wood samples. The results highlighted that the oil-based varnish led to a decrease in the speed of propagation in the radial direction, compared to the alcoholic varnish, whose major effect was in the longitudinal direction, on the spruce wood. On maple wood, increasing the number of varnish layers, regardless of the type of varnish, led to a decrease in the anisotropy ratio between the longitudinal and radial directions.
Rhodamine B-Containing Chitosan-Based Films: Preparation, Luminescent, Antibacterial, and Antioxidant Properties
Authors: Khubiev Omar M. , Egorov Anton R. , Semenkova Daria I. , Salokho Darina S. , Golubev Roman A. , Sikaona Nkumbu D. , Lobanov Nikolai N. , Kritchenkov Ilya S. , Tskhovrebov Alexander G. , Kirichuk Anatoly A. , Khrustalev Victor N. , Kritchenkov Andreii S.
Published: March 2024

In this study, Rhodamine B-containing chitosan-based films were prepared and characterized using their mechanical, photophysical, and antibacterial properties. The films were synthesized using the casting method and their mechanical properties, such as tensile strength and elongation at break, were found to be dependent on the chemical composition and drying process. Infrared spectroscopy and X-ray diffraction analysis were used to examine the chemical structure and degree of structural perfection of the films. The photophysical properties of the films, including absorption spectra, fluorescence detection, emission quantum yields, and lifetimes of excited states, were studied in detail. Rhodamine B-containing films exhibited higher temperature sensitivity and showed potential as fluorescent temperature sensors in the physiological range. The antibacterial activity of the films was tested against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli, with Rhodamine B-containing films demonstrating more pronounced antibacterial activity compared to blank films. The findings suggest that the elaborated chitosan-based films, particularly those containing Rhodamine B can be of interest for further research regarding their application in various fields such as clinical practice, the food industry, and agriculture due to their mechanical, photophysical, and antibacterial properties.
Nanocomposites of Conducting Polymers and 2D Materials for Flexible Supercapacitors
Authors: Zhu Haipeng , Xu Ruiqi , Wan Tao , Yuan Wenxiong , Shu Kewei , Boonprakob Natkritta , Zhao Chen
Published: March 2024

Flexible supercapacitors (FSCs) with high electrochemical and mechanical performance are inevitably necessary for the fabrication of integrated wearable systems. Conducting polymers with intrinsic conductivity and flexibility are ideal active materials for FSCs. However, they suffer from poor cycling stability due to huge volume variations during operation cycles. Two-dimensional (2D) materials play a critical role in FSCs, but restacking and aggregation limit their practical application. Nanocomposites of conducting polymers and 2D materials can mitigate the above-mentioned drawbacks. This review presents the recent progress of those nanocomposites for FSCs. It aims to provide insights into the assembling strategies of the macroscopic structures of those nanocomposites, such as 1D fibers, 2D films, and 3D aerogels/hydrogels, as well as the fabrication methods to convert these macroscopic structures to FSCs with different device configurations. The practical applications of FSCs based on those nanocomposites in integrated self-powered sensing systems and future perspectives are also discussed.
Evaluate the Structural and Physicochemical Properties of Exopolysaccharides Produced by Bacillus halotolerans Isolated from Locally Sourced Vegetables
Authors: Dai Yutian , Xu Min , Zhou Zhijiang , Han Ye
Published: March 2024

In this study, a Bacillus halotolerans (B. halotolerans) strain DT1 capable of producing exopolysaccharides (EPS) was isolated from dried cabbages of Tianjin, a local fermented vegetable product. Three distinct polysaccharide fractions were isolated from the fermentation broth of DT1, namely, DT1-0, DT1-2, and DT1-5. The structural composition and properties of these fractions were investigated. The predominant EPS, DT1-0, was identified as a novel heteropolysaccharide composed of fructose and glucose with branched structures. The repeating unit was determined to be [4)-α-D-Glcp-(1→6)-α-D-Glcp-(1→6)-β-D-Fruf-(2→6)-β-D-Fruf-(2→6-)-β-D-Fruf-(2→], with fructose and glucose connected by β-(2→1) and α-(1→4) glycosidic linkages between the third fructose and the first glucose, respectively. The molecular weight (Mw) was estimated to be 4.253 × 103 Da. DT1-0 presented a smooth and porous surface structure as observed through SEM and exhibited a water-holding capacity of 504 ± 5.3%, maximum thermal stability at 245 °C, and an oil-holding capacity of 387 ± 1.9% for coconut oil. DT1-2 was identified as a fructooligosaccharide. DT1-5 was characterized as a polysaccharide composed of glucose and fructose. In conclusion, these findings provide substantial support for the further application of B. subtilis strain DT1 and its EPS fractions, DT1-0, DT1-2, and DT1-5, as potential alternatives for functional food additives or ingredients.
Investigation of the Reaction between a Homemade PEEK Oligomer and an Epoxy Prepolymer: Optimisation of Critical Parameters Using Physico–Chemical Methods
Authors: Stampfer Léopold , Bouilhac Cécile , Mérian Tiphaine , Chabert France , Djilali Toufik , Nassiet Valérie , Habas Jean-Pierre
Published: March 2024

Several researchers have examined the interest in using a thermoplastic to increase thermoset polymers’ shock resistance. However, fewer studies have examined the nature of the mechanisms involved between both kinds of polymers. This was the objective of our work, which was carried out using a gradual approach. First, we describe the synthesis of a poly(ether ether ketone) oligomer (oPEEK) with hydroxyl terminations from the reaction of hydroquinone and 4,4′-difluorobenzophenone in N-methyl-2-pyrrolidone. Then, the main physicochemical properties of this oligomer were determined using different thermal analyses (i.e., differential scanning calorimetry (DSC), thermogravimetric (ATG), and thermomechanical analyses) to isolate its response alone. The chemical characterisation of this compound using conventional analytical chemistry techniques was more complex due to its insolubility. To this end, it was sulfonated, according to a well-known process, to make it soluble and enable nuclear magnetic resonance (NMR) and size exclusion chromatography (SEC) experiments. Additional information about the structural and chemical characteristics of the oligomer and its average molecular weight could thus be obtained. The synthesis of an oligoPEEK with α,ω-hydroxyl end-groups and a molecular weight of around 5070 g/mol was thus confirmed by NMR. This value was in accordance with that determined by SEC analysis. Next, the reaction of oPEEK with an epoxy prepolymer was demonstrated using DSC and dynamic rheometry. To this end, uncured mixtures of epoxy prepolymer (DGEBA) with different proportions of oPEEK (3, 5, 10 and 25%) were prepared and characterised by both techniques. Ultimately, the epoxy-oPEEK mixture was cured with isophorone diamine. Finally, topological analyses were performed by atomic force microscopy (AFM) in tapping mode to investigate the interface quality between the epoxy matrix and the oPEEK particles indirectly. No defects, such as decohesion areas, microvoids, or cracks, were observed between both systems.
A Study of Deployable Structures Based on Nature Inspired Curved-Crease Folding
Authors: Dutta Gaurab Sundar , Meiners Dieter , Ziegmann Gerhard
Published: March 2024

Fascinating 3D shapes arise when a thin planar sheet is folded without stretching, tearing or cutting. The elegance amplifies when the fold/crease is changed from a straight line to a curve, due to the association of plastic deformation via folding and elastic deformation via bending. This results in the curved crease working as a hinge support providing deployability to the surface which is of significant interest in industrial engineering and architectural design. Consequently, finding a stable form of curved crease becomes pivotal in the development of deployable structures. This work proposes a novel way to evaluate such curves by taking inspiration from biomimicry. For this purpose, growth mechanism in plants was observed and an analogous model was developed to create a discrete curve of fold. A parametric model was developed for digital construction of the folded models. Test cases were formulated to compare the behavior of different folded models under various loading conditions. A simplified way to visualize the obtained results is proposed using visual programming tools. The models were further translated into physical prototypes with the aid of 3D printing, hybrid and cured-composite systems, where different mechanisms were adopted to achieve the folds. The prototypes were further tested under constrained boundary and compressive loading conditions, with results validating the analytical model.
Characterization of Radiation Shielding Capabilities of High Concentration PLA-W Composite for 3D Printing of Radiation Therapy Collimators
Authors: Velásquez José , Fuentealba Melani , Santibáñez Mauricio
Published: March 2024

This work evaluates the radiation shielding capabilities of the PLA-W composite for MV energy photons emitted by a linear accelerator and the feasibility of manufacturing a clinically-used collimator grid in spatially fractionated radiotherapy (SFRT) using the material extrusion (MEX) 3D printing technique. The PLA-W filament used has a W concentration of 93% w/w and a green density of 7.51 g/cm3, characteristics that make it suitable for this purpose. Relevant parameters such as the density and homogeneity distribution of W in the manufactured samples determine the mass attenuation coefficient, directly affecting the radiation shielding capacities, so different printing parameters were evaluated, such as layer height, deposition speed, nozzle temperature, and infill, to improve the protection performance of the samples. Additionally, physical and mechanical tests were conducted to ensure structural stability and spatial variability over time, which are critical to ensure precise spatial modulation of radiation. Finally, a complete collimator grid measuring 9.3 × 9.3 × 7.1 cm3 (consisting of 39 conical collimators with a diameter of 0.92 cm and center-to-center spacing of 1.42 cm) was manufactured and experimentally evaluated on a clinical linear accelerator to measure the radiation shielding and dosimetric parameters such as mass attenuation coefficient, half-value layer (HVL), dosimetric collimator field size, and inter-collimator transmission using radiochromic films and 2D diode array detectors, obtaining values of 0.04692 cm2/g, 2.138 cm, 1.40 cm, and 15.6%, respectively, for the parameters in the study. This shows the viability of constructing a clinically-used collimator grid through 3D printing.
The Relationship between Religiosity Level and Emotional Responses to Artificial Intelligence in University Students
Authors: Kozak Jaroslaw , Fel Stanislaw
Published: March 2024

This article aims to analyze the correlations between the level of religiosity and emotional responses to artificial intelligence (AI). In these times marked by the growing penetration of artificial intelligence into people’s everyday lives, it is important to identify the sociocultural determinants of attitudes towards this increasingly dynamically developing technology. A significant element of society’s cultural mosaic is religiosity, and, as such, it undoubtedly has an effect on emotional responses to AI. This is a reason to investigate how religions and religiosity impact attitudes towards AI. The study used Welch’s analysis of variance (ANOVA) to compare university students’ emotional reactions to AI across religiosity levels, which allowed for identifying significant differences in the levels of emotions such as fear, sadness, and anger between irreligious, religious, and indifferent groups. Significant differences in emotional responses to AI were found between individuals with different religiosity levels. Compared to irreligious and indifferent students, the religious ones more often showed intense emotions, such as fear and anger. The results indicate the need to include the issues of religion and religiosity in the process of designing and implementing AI. This may contribute to a greater acceptance of this technology in a society of individuals with different levels of religiosity. Understanding the effect of religiosity on the response to AI is also of considerable importance for the development and implementation of ethically responsible AI solutions, which should take account of the diversity of individuals’ beliefs and value systems.
Cross-Parallel Attention and Efficient Match Transformer for Aerial Tracking
Authors: Deng Anping , Han Guangliang , Zhang Zhongbo , Chen Dianbing , Ma Tianjiao , Liu Zhichao
Published: March 2024

Visual object tracking is a key technology that is used in unmanned aerial vehicles (UAVs) to achieve autonomous navigation. In recent years, with the rapid development of deep learning, tracking algorithms based on Siamese neural networks have received widespread attention. However, because of complex and diverse tracking scenarios, as well as limited computational resources, most existing tracking algorithms struggle to ensure real-time stable operation while improving tracking performance. Therefore, studying efficient and fast-tracking frameworks, and enhancing the ability of algorithms to respond to complex scenarios has become crucial. Therefore, this paper proposes a cross-parallel attention and efficient match transformer for aerial tracking (SiamEMT). Firstly, we carefully designed the cross-parallel attention mechanism to encode global feature information and to achieve cross-dimensional interaction and feature correlation aggregation via parallel branches, highlighting feature saliency and reducing global redundancy information, as well as improving the tracking algorithm’s ability to distinguish between targets and backgrounds. Meanwhile, we implemented an efficient match transformer to achieve feature matching. This network utilizes parallel, lightweight, multi-head attention mechanisms to pass template information to the search region features, better matching the global similarity between the template and search regions, and improving the algorithm’s ability to perceive target location and feature information. Experiments on multiple drone public benchmark tests verified the accuracy and robustness of the proposed tracker in drone tracking scenarios. In addition, on the embedded artificial intelligence (AI) platform AGX Xavier, our algorithm achieved real-time tracking speed, indicating that our algorithm can be effectively applied to UAV tracking scenarios.
A Spatial Downscaling Method for Solar-Induced Chlorophyll Fluorescence Product Using Random Forest Regression and Drought Monitoring in Henan Province
Authors: Zhang Zhaoxu , Li Xutong , Qiu Yuchen , Shi Zhenwei , Gao Zhongling , Jia Yanjun
Published: March 2024

Drought is a frequent global phenomenon. Solar-induced chlorophyll fluorescence (SIF), an electromagnetic signal, has been proven to be an efficient tool for monitoring and assessing gross primary productivity (GPP) and drought. To address the issue of the sparse resolution of satellite-based SIF, researchers have developed different downscaling algorithms. Recently, the most frequently used SIF products had a spatial resolution of 0.05 degrees. However, these spatial resolution SIF data are not conducive to regional agricultural drought monitoring. In this study, we utilized the global ‘OCO-2’ solar-induced fluorescence (GOSIF) products along with normalized difference vegetation index (NDVI) and land surface temperature (LST) products. With the powerful advantages offered by Google Earth Engine (GEE), we could conveniently acquire the necessary data. Additionally, employing the random forest (RF) method, we successfully acquired downscaled SIF data at an enhanced spatial resolution of 1 km. Using those downscaled SIF results with 1 km resolution, an SIF anomaly index was established and calculated to monitor drought. Results showed that the RF-based downscaled SIF result followed the same trend as the GOSIF value. Subsequently, correlation coefficients between SIF and GPP were calculated. The downscaled SIF demonstrated a higher correlation with GPP from MODIS compared to 0.05-degree GOSIF, with coefficients of 0.74 and 0.68 in May 2018, respectively. Moreover, the SIF anomaly index showed positive correlations with crop yield; the correlation coefficients were 0.93 for wheat and 0.89 for maize. The drought index had a negative correlation with areas affected by drought, with a correlation coefficient of −0.58. Finally, the SIF anomaly index was used to monitor drought from 2001 to 2020 in Henan Province. The 1 km SIF results obtained through the RF-based downscaled method were deemed reliable, thereby establishing the suitability of the SIF anomaly index for drought monitoring at a regional scale.
A Review of Remote Sensing of Atmospheric Profiles and Cloud Properties by Ground-Based Microwave Radiometers in Central China
Authors: Xu Guirong
Published: March 2024

Thermodynamic and liquid water profiles can be retrieved by a ground-based microwave radiometer (MWR) in nearly all weather conditions, which is useful for detecting mesoscale phenomena. This paper reviews the advances in remote sensing of atmospheric profiles and cloud properties by MWR in central China. Comparative studies indicate that MWR retrieval accuracy is different under various skies, especially those that decay under precipitation. The off-zenith method is proven to be capable of reducing the impact of precipitation and snow on MWR retrieval accuracy. Application studies demonstrate that MWR retrievals are helpful for early warning of rainstorms, hailstorms, and thunderstorms. Moreover, MWR retrievals provide a way to study cloud properties. The temporal variations of cloud occurrence frequency (COF) and liquid water path (LWP) are different for low, middle, and high clouds, and the vertical distribution of COF is also different in autumn and other seasons. Note that MWR can infer valid retrievals over the eastern Tibetan Plateau due to the weak precipitation over there. Also, cloud properties over the eastern Tibetan Plateau present differences from those over central China, and this is related to the different characteristics of atmospheric water vapor between these two regions. To bring more benefits for mechanism study and early warning of severe weather and numerical weather prediction, the decayed accuracy of MWR zenith retrievals under precipitation should be resolved. And combining MWR with other instruments is necessary for MWR application in detecting multi-layer clouds and ice clouds.
Evaluating the Point Cloud of Individual Trees Generated from Images Based on Neural Radiance Fields (NeRF) Method
Authors: Huang Hongyu , Tian Guoji , Chen Chongcheng
Published: March 2024

Three-dimensional (3D) reconstruction of trees has always been a key task in precision forestry management and research. Due to the complex branch morphological structure of trees themselves and the occlusions from tree stems, branches and foliage, it is difficult to recreate a complete three-dimensional tree model from a two-dimensional image by conventional photogrammetric methods. In this study, based on tree images collected by various cameras in different ways, the Neural Radiance Fields (NeRF) method was used for individual tree dense reconstruction and the exported point cloud models are compared with point clouds derived from photogrammetric reconstruction and laser scanning methods. The results show that the NeRF method performs well in individual tree 3D reconstruction, as it has a higher successful reconstruction rate, better reconstruction in the canopy area and requires less images as input. Compared with the photogrammetric dense reconstruction method, NeRF has significant advantages in reconstruction efficiency and is adaptable to complex scenes, but the generated point cloud tend to be noisy and of low resolution. The accuracy of tree structural parameters (tree height and diameter at breast height) extracted from the photogrammetric point cloud is still higher than those derived from the NeRF point cloud. The results of this study illustrate the great potential of the NeRF method for individual tree reconstruction, and it provides new ideas and research directions for 3D reconstruction and visualization of complex forest scenes.