bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic Epstein-Barr viral infection in children: a clinical case
Authors: Kokoreva S. P. , Kotlova V. B. , Razuvaev O. A.
Published: November 2021

The urgency of Epstein-Barr virus infection is explained by wide circulation of Epstein-Barr virus among children and adults, its tropism to immunocompetent cells with lifelong persistence after primary infection and polymorphism of clinical manifestations from subclinical forms, infectious mononucleosis to formation of oncological, autoimmune hematological diseases.

Persistence of Epstein - Barr virus Leads to suppression of cellular immunity, decreased production of interferons and nonspecific protection factors, which contributes to reactivation of persistent infection, most often without mononucleosis-like syndrome, and the appearance of atypical mononuclears in blood with the formation of lymphoproliferative, intoxication, astheno-vegetative syndrome, long-term subfebrile condition, which dictates the need for immunocorrective therapy. This article presents a clinical case describing and analyzing the course of a chronic Epstein-Barr virus infection in a preschool child (5 years 8 months) with a pre-morbid background. Episodes of reactivation of chronic persistent infection occurred under the mask of acute respiratory infection with lymphoproliferative syndrome, purulent tonsillitis, purulent adenoiditis. Therapy, including antibiotics, short-course antiviral agents, bacterial lysates, and physiotherapy, had a temporary and short-lived effect. meglumine acridonacetate. The described clinical case demonstrates the effectiveness of the inclusion of meglumine acridonacetate, which has antiviral, immunomodulatory and anti-inflammatory effects, in the complex treatment of Epstein-Barr virus infection, This allowed to obtain fairly rapid positive clinical dynamics of relieving intoxication and febrile and lymphoproliferative syndromes in the acute period, and subsequently - astheno-vegetative syndrome and achieve the transition of active chronic Epstein - Barr virus infection into a latent form.
Management of children with allergic rhinitis in the practice of a local pediatrician
Authors: Koltuntceva I. V. , Gaiduk I. M. , Sakhno L. V. , Bairova S. V.
Published: November 2021

Due to the increase in the weight of allergic diseases in the general pathology of childhood, the diagnosis and treatment of allergic rhinitis in children and the management of these patients at the outpatient stage have not lost their relevance. The period of preschool and school age is characterized by a high frequency of acute respiratory diseases of the upper respiratory tract, especially acute rhinitis, rhinopharyngitis, rhinosinusitis. This daily poses to the district pediatrician the tasks of differential diagnosis of allergic rhinitis and acute rhinitis with a prolonged course. Allergic rhinitis most often does not require hospitalization and, with timely diagnosis, does not lead to serious consequences. It is known that children who are prone to allergies suffer from acute respiratory viral infections more often and more severely than their peers. An integrated approach to the diagnosis and treatment of such children with the participation of an allergist, an otorhinolaryngologist, under the constant supervision of a district pediatrician, the rational use of drug therapy can reduce the duration of the disease, improve the quality of life of the patient.

The article presents generalized principles of management of patients with allergic rhinitis from the point of view of domestic and international recommendations, describes in detail the rules of life for children with allergic rhinitis, emphasizes the role of the district pediatrician in teaching parents to ensure a hypoallergenic environment of the child. The authors present a clinical example of the effective use of a combined decognensant and an antihistamine for the treatment of acute respiratory viral infections in a child with allergic rhinitis.
Osteogenesis imperfecta: a literature review and a clinical case of a perinatal-lethal type of disease
Authors: Klimov L. Ya. , Vdovina T. M. , Pechenkina V. A. , Zhelezniakova T. V. , Zakharova I. N. , Dolbnya S. V. , Kuryaninova V. A. , Kastarnov A. V. , Shmalko D. A. , Tsutsaev R. O. , Bykov Yu. V.
Published: November 2021

The article presents the modern views of clinicians and geneticists on one of the most severe genetic disorders of skeletal and connective tissues - osteogenesis imperfecta. The review provided the literature data that showed the incidence rates, genetic heterogeneity of osteogenesis imperfecta, as well as the role of some proteins involved in the construction of bone tissue, as well as a clinical classification of the main types of the disorder. The authors described a clinical case: a girl with typical clinical and radiological manifestations of the rarest of all types of osteogenesis imperfecta - type II (perinatal-lethal, congenital osteogenesis imperfecta, Vrolik’s syndrome). The child’s diagnosis was verified by a parallel DNA sequence analysis which showed a heterozygous mutation in exon 29 (c.1966G> A) of COL1A1 gene not previously described in the literature. It caused the substitution of glycine for serine at position 656. The role of antenatal diagnostics and the importance of medical genetic counselling of the family before planning the next pregnancy due to the existing risk of re-birth of a sick child is outlined. Due to the fact that majority of the patients with the most prognostically unfavourable type II osteogenesis imperfecta, as a rule, die in utero, the described case of observation of the girl with typical clinical and X-ray signs of the disorder for almost 3 months of postpartum period is extremely rare and highly indicative. The detection of the heterozygous mutation in exon 29 (c.1966G > A) of COL1A1 gene by a parallel DNA sequence analysis which was not previously described in the literature gives an additional significance to the described observation.
Infant colic: where is the line between norm and pathology, the role of disruption of the intestinal microbiome
Authors: Panova L. D.
Published: November 2021

Infant colic is one of the most common functional disorders of the gastrointestinal tract in children of the first year of life, worsening the condition of both the child himself and the psychological climate in the family. Infant intestinal colic is a multifactorial symptom complex that requires differential diagnosis between norm and pathology. Until now, there is no clear understanding of the criteria for the need for dietary and drug correction of this condition. The article presents an analysis of the modern literature on the problem of intestinal colic in infants The pathogenesis of functional intestinal colic is determined by a combination of reasons, including the immaturity of the central nervous system, hypothalamic-pituitary system, regulation of the intestinal innervation and the enzymatic system, a certain dependence on psychosocial factors has also been identified, the intestinal microflora has a great influence. H. Kianifar et al. (2014) in the findings of a study noted that a multiprobiotic (seven strains of probiotics and fructooligosaccharides) significantly improved colic symptoms, in particular a reduction in crying time, (82.6%) compared with placebo (35.7%) on day 7 of intake (p < 0.005). On day 30, treatment success was 87% and 46% in the synbiotics and placebo groups, respectively (p < 0.01). The results of a domestic study by I.N. Zakharova et al. (2016) multiprobiotic, which showed that after the use of a multistrain probiotic, intestinal colic remained in 3 (10%) children of the main group and in all children in the placebo group. After taking the probiotic, 80% of children showed normalization of stool, and in the placebo group, stool disorders (loose, watery stools or no stool with the need to empty after an enema) were recorded in 87% of children. Cases from clinical practice with experience of using a multistrain probiotic for colic are shown.
Hypercholesterolemia in children and adolescents: focus on the familial variant
Authors: Zakharova I. N. , Osmanov I. M. , Pshenichnikova I. I. , Tvorogova T. M. , Kholodova I. N. , Berezhnaya I. V. , Skorobogatova E. V. , Kholodov D. I. , Bocharova T. I. , Koba Yu. V.
Published: November 2021

Familial hypercholesterolemia is characterized by a significant increase in serum low-density lipoprotein cholesterol concentration, which even in the absence of other risk factors leads to the development of atherosclerotic vascular lesions beginning in childhood. With significant prevalence in the population, familial hypercholesterolemia is rarely diagnosed in time due to the Long absence of clinical manifestations. Today the urgent task is to develop and implement programs of primary detection of familial hypercholesterolemia in children and adolescents. Early detection of patients with familial hypercholesterolemia and timely initiation of adequate lipid-lowering therapy will curb the rate of atherosclerosis progression, which will significantly reduce disability and mortality from cardiovascular diseases in older age groups. There are four types of screening: cascade, targeted, opportunistic and universal. Cascade screening is currently considered the most effective and cost-effective way to identify new patients with familial hypercholesterolemia among relatives of an index patient, the patient with the established diagnosis. Targeted screening is based on searching for individuals with familial hypercholesterolemia among groups of patients with the early development of atherosclerotic vascular lesions, for example, in cardiology or neurology hospitals. Opportunistic screening is a non-systematic, sporadic determination of cholesterol levels in patients seeking medical care for any reason. It is most applicable in primary care health care settings. Universal screening is a mass screening of certain age groups and is a highly effective way of early diagnosis, especially in combination with reverse cascade screening of parents, siblings, and other relatives of the index patient. Implementation of programs of early childhood detection of familial hypercholesterolemia, setting up systems of adequate routing of patients, timely prescription of effective lipid-lowering therapy will contribute to health preservation and prolongation of working age, development, and preservation of labor potential of the country.
Possibilities of inhalation bacteriophage therapy in treatment of children with acute tonsillitis
Authors: Turdieva Sh. T. , Nasirova G. R. , Ganiyeva D. K.
Published: November 2021

Introduction. At the same time, in the last decade, pediatricians have increased interest in the study of the therapeutic effect of bacteriophages in infectious diseases of rhinolaryngological organs.

Objective. The analysis of results of the use of inhalation bacteriophage therapy in children with acute tonsillitis, on an outpatient basis.

Materials and methods. Examined 212 children from 4 to 15 years old with acute tonsillitis. Conducted general clinical research, pharyngoscopy, bacteriological examination of a smear of tonsils. Bacteriophage therapy carried out using the Pyobacteriophage complex liquid (PCL).

Results. In the course of an objective clinical analysis, on the day of seeking outpatient care, patients noted asthenovegetative disorders in all patients (100%), in the form of general weakness (96.8%), loss of appetite (94.8%), and headache (92.5%). During the examination, cervical lymphadenopathy (98.6%), tonsil hyperemia and hyperplasia (98.1%), and exudates (48.1%) noted. It revealed that the main causative agents of acute tonsillitis in children were the bacteria Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae, with different relative proportions (from 24.2% to 59%). Inhalation bacteriophage therapy carried out from the first days of the disease. Against the background of therapy, it was noted - a decrease in swelling in the tonsils by 2-3 days with a decrease in general intoxication signs. On the 6th day from the beginning of bacteriophage therapy, asthenovegetative disorders stopped 2.2 times faster in relation to patients who did not receive bacteriophage therapy, against the background of a decrease in the manifestation of objective clinical signs of the disease.

Conclusion. The use of inhalation bacteriophage therapy as part of the conservative treatment of acute tonsillitis in children contributes 1.4 times to the fastest relief of the acute period and an improvement in the subjective assessment of well-being is 25% higher concerning the comparison group.
İNGİLİZCE ÖĞRETMENLERININ İNGİLİZCE DERSİ EĞİTİM PROGRAMINA İLİŞKİN ALGILARININ METAFORLAR YOLUYLA İNCELENMESİ
Authors: Yıldız Hatice , Korkmazgil Sibel
Published: November 2021

Bu araştırma, İngilizce öğretmenlerinin İngilizce dersi eğitim programına (İDEP) ilişkin algılarını metaforlar aracılığıyla tespit etmek amacıyla yapılmıştır. Araştırmaya İç Anadolu Bölgesi’nin bir ili merkez ilçesinde görev yapan 59 İngilizce öğretmeni katılmıştır. Araştırmaya katılan öğretmenlere İDEP’e ilişkin algılarını ortaya koymaları için açık uçlu bir anket formu uygulanmıştır. Anket formunda öğretmenlerden “İngilizce eğitim programı … gibidir; çünkü …” cümlesini tamamlamaları istenmiştir. Öğretmenlerin İDEP’e ilişkin düşünceleri içerik analizi tekniği ile çözümlenmiştir. Araştırma sonucunda öğretmenlerin İDEP’e ilişkin olarak toplam 54 adet metafor ürettikleri görülmüştür. Öğretmenler tarafından en çok üretilen metaforlar “hayat, hedefe ulaştıran yol, iskelet ve yemek”tir. Öğretmenlerin ürettikleri metaforlardan; zaruri/gerekli olarak program, sistematik bir yapı olarak program, araç/vasıta olarak program, kaynak olarak program, rehber olarak program, gelişim olarak program, çeşitlilik sunan bir yapı olarak program, kararsız ve sürekli değişen bir yapı olarak program ve yararsız olarak görülen program olmak üzere toplam 9 kategori oluşturulmuştur.
Abstracts of the 11th Congress of the African Association of Nephrology (Dakar, 16th-19th February 2011)
Authors: Assounga Alain
Published: November 2021

Dakar, 16th-19th February 2011
Editorial note
Authors: Assounga Alain
Published: November 2021

In this issue of The African Journal of Nephrology (AJN Vol 17 No1) we publish an important editorial sponsored by the International Society of Nephrology.
Editorial note
Authors: Assounga Alain
Published: November 2021

As the official journal of the African Association of Nephrology (AFRAN), the African Journal of Nephrology (AJN) publishes research on kidney diseases by African and other researchers. AJN has reached a significant milestone in this first issue of Volume 20. This is the first issue which was prepared and published using our new web-based platform. We wish to take this opportunity to thank the editorial board, the reviewers and the authors for their role in the successful migration to the new platform. To mark this milestone, and to coincide with the March 2017 AFRAN/AFPNA Congress in Cameroon, we are delighted to publish a special article on the history of AFRAN by Professor Rashad Barsoum, one of the co-founders of AFRAN. Contributions to the success of AFRAN by the International Society of Nephrology, and by colleagues from Europe, America and Africa, are acknowledged. This is an illustrated story of our association told by its founding president, which is now immortalised in AJN. This issue also features an original article reporting on malignant kidney tumours in Port Harcourt, Nigeria. Nephroblastoma and renal cell carcinoma remain the leading kidney malignancies, as also reported worldwide. Finally, two interesting case reports conclude this issue: a case of IgG4-related nephropathy and a successful pregnancy in a patient on chronic haemodialysis.
Correction: South African Renal Registry Annual Report 2015 - kidney transplants in KwaZulu-Natal
Authors: Hariparshad Sudesh
Published: November 2021

This correction serves to update the reported numbers of new kidney transplants performed annually since 2012 in the public sector in the province of KwaZulu-Natal.
Diffuse infiltrative lymphocytosis syndrome presenting as renal failure in South African HIV-positive individuals: a single-centre case series
Authors: McMullen Kate , Borkum Megan , Botha Francois CJ , Duffield Maureen , Wearne Nicola
Published: November 2021

Diffuse infiltrative lymphocytosis syndrome (DILS) in human immunodeficiency virus (HIV) infection presented most commonly with parotidomegaly and sicca symptoms in the pre-antiretroviral era. However, numerous clinical manifestations are possible due to the multi-organ nature of the CD8+ lymphocytic infiltration. Renal involvement is infrequently described, but common characteristics of a renal syndrome associated with DILS have been identified. This case series describes four South African HIV-positive patients with DILS, in whom renal failure was the sole clinical manifestation. As DILS responds well to antiretroviral and corticosteroid therapy, this series highlights the importance of considering this syndrome as a cause of renal failure in an HIV-positive patient.
Hyperprolactinaemia in a patient with kidney failure
Authors: Parak Amirah , Daya Reyna , Bulbulia Saajidah , Seedat Faheem , Bayat Zaheer
Published: November 2021

Hyperprolactinaemia is a common endocrine abnormality in patients with kidney failure. A 43-year-old female, known with kidney failure on maintenance haemodialysis, was referred with symptomatic hyperprolactinaemia. Biochemical investigations revealed a markedly elevated serum prolactin level. Magnetic resonance imaging of the brain (without gadolinium) demonstrated a pituitary macroadenoma. The patient was started on cabergoline therapy. This case discusses hyperprolactinaemia in kidney failure and highlights the importance of investigating markedly elevated prolactin levels. In cases where patients have galactorrhoea, headaches and/or visual disturbances, clinicians should be alert to the possibility of a prolactin-secreting pituitary tumour.
Assessment transition of exercise and dietary habit of athletes before and during Ramadan in the pandemic of Covid-19
Authors: Kurniawan Toni , Mustar Yetty Septiani , Hariyanto Agus , Susanto Indra Himawan , Noordia Anna
Published: November 2021

This study aims to identify the training transitions and dietary habits of volleyball athletes' before and during Ramadan in the Covid-19 pandemic. The research design used is descriptive quantitative with a sample of 12 male junior volleyball athletes in the academy Sidoarjo volleyball. The results showed that most athletes experienced a decrease in the frequency of exercise during the month of Ramadan, especially during the COVID-19 pandemic. A total of 33.3% of athletes maintained their exercise frequency, and 66.7% experienced a decrease in exercise frequency. Furthermore, during Ramadan and Covid-19, there was an increase in the frequency of eating 1-2 times a day (58.4%), snack consumption (50%), fruit and vegetables (75%), fried foods 4-7 times a week (8.4%), instant noodles 1-3 times a week (25%) and fast food 1-3 times a week (8.4%) in athletes. Concerning this, it is imperative to revitalize the program and monitor the athlete's training periodically, which is adjusted to the conditions of the COVID-19 pandemic and provide a dietitian to regulate the athlete's diet to obtain a balanced nutritional intake following the exercise portion.Assessmen transisi latihan dan pola makan atlet sebelum dan saat ramadan di masa pandemi Covid-19AbstrakTujuan dari penelitian ini adalah untuk mengidentifikasi transisi latihan dan pola makan atlet bola voli sebelum dan saat ramadan di masa pandemi Covid-19. Desain penelitian yang digunakan yaitu deskriptif kuantitatif dengan sampel 12 atlet laki-laki bola voli junior yang masih aktif dalam menjalani pemusatan latihan di Akademi Bola Voli Indomaret Sidoarjo. Hasil penelitian menunjukkan bahwa mayoritas atlet mengalami penurunan frekuensi latihan saat ramadan khususnya di masa pandemi covid-19. Sebanyak 33,3% yang mampu mempertahankan frekuensi latihan dan 66,7% mengalami penurunan frekuensi latihan. Selanjutnya, saat ramadan dan Covid-19 terjadi peningkatan frekuensi makan 1-2 sehari (58,4%), konsumsi camilan (50%), buah dan sayuran (75%), gorengan 4 – 7 kali dalam seminggu (8,4%), mie instant 1 – 3 kali dalam satu minggu (25%)  serta makanan cepat saji  1 – 3 kali dalam seminggu (8,4%) pada atlet. Berdasarkan hal ini, maka sangat penting untuk melakukan revitalisasi program dan pemantauan latihan atlet secara berkala yang disesuaikan dengan masa pandemi covid-19 dan menyediakan dietisien untuk pengaturan makan atlet agar dapat memperoleh asupan gizi seimbang sesuai dengan porsi latihannya.
The Profile of Task Performances for Cognitive-communicative Intervention in the Oldest-Old
Authors: Lee Mi Sook
Published: November 2021

Purpose: The “oldest-old” is the heterogeneous population compared with the younger-old in several cognitive-communication aspects. Accordingly, it is necessary to intervene in them discriminately. This study aimed to suggest the performance profiles by cognitive-communication tasks for intervention in oldest-old.Methods: Sixty-four oldest-old subjects aged 80 or older years performed 16 subtasks for the five cognitive-communication domains. And the performance profiles of group I (84.00 ± 2.62 years) and II (93.38 ± 1.61 years) were analyzed.Results: The main findings were as follows. Firstly, two groups had significant differences in performances of most tasks including working memory, reasoning, word fluency, and subjective communication. Secondly, five communication tasks were significantly correlated with all cognitive tasks and were predicted by the reasoning tasks like similarity in group I. Thirdly, word fluency and pragmatic expression tasks were significantly correlated with all cognitive tasks. Tasks including verbal problem solving were found to be the best predictors of confrontation naming in group II.Conclusion: Current study provides evidence-based information to support cognitive-communication intervention for the oldest-old. These results also can contribute to increase the efficacy of the cognitive-communicative intervention.
The Noise Level Measurements of Children’s Sound Books
Authors: Joo Seok-Hee , Shin Eun-Yeong
Published: November 2021

Purpose: It was intended to measure the sound intensity of children's sound books and to compare them with the standards of Korea and the International Standards Organization (ISO).Methods: The loudness of 15 children’s sound books was measured at a distance of 25 cm (child’s arm length), and 2.5 cm length of external auditory canal. Measurements taken three times with each book were performed, and the overall sound intensity of the sound books and the sound intensity of each button were measured and compared.Results: Compared with the Korean standard, all the buttons of all books exceeded the standard for the sound volume of the children’s book measured at a distance of 2.5 cm. When comparing the maximum sound intensity measured at a distance of 25 cm with 85 LAmax, a total of 168 buttons of these, 25 (14.88%) were recorded as exceeding the maximum loudness. According to the standards of the ISO, all buttons in all books were below the standard 85 LAeq.Conclusion: Several children’s books are loud enough to cause noise-induced hearing loss, especially when they are placed close to the ear. Strict standards for sound children’s books are required, and it is important to put a warning on the cover of the book. It is expected that the sound intensity of the children’s sound book presented in this study can be referenced when referring to the loudness during hearing rehabilitation in children.
Hearing Aid Selection: Closed- versus Open-canal Fitting Hearing Aids
Authors: Lee Sangyeon , Oh Soo Hee , Lee Kyoungwon
Published: November 2021

To select hearing aid is an essential process for successful hearing rehabilitation. The purpose of this study is to review hearing aid selection considerations between receiver in-the-canal (RIC) and custom hearing aid (CHA) in order to guide appropriate selection of the hearing aid. This study discussed three key factors in the hearing aid selection including physical, acoustic and electroacoustic characteristics and other aspects. Advantages of RIC types are comfort to wear, reduction of the occlusion effect, presence of directional microphones, on-site fit, easy connectivity with other devices, and use of rechargeable batteries. On the other hand, the CHA types have their advantage in terms of being comfort to wear with masks, proper insertion and placement, reduction of the acoustic feedback, good approximation of frequency response curve, improvement of speech in noise perception, expanded hearing aid candidacy with varying hearing thresholds, and easy telephone use. We concluded that appropriate selection of the hearing aid would contribute to successful hearing rehabilitation, if considering physical, psycho-social, and acoustical characteristics.
Coronavirus Disease 2019 Vaccination during Pregnancy
Authors: Lee Seong Hyeon , Ahn Ki Hoon
Published: November 2021

Several vaccines have been developed to combat the coronavirus disease 2019 (COVID-19), including messenger Ribonucleic acid (mRNA, Pfizer-BioNtech, and Moderna) and viral vector (AstraZeneca and Janssen) types. Unfortunately, reports of COVID-19 exposure during pregnancy are scarce, as pregnancy and breastfeeding were among the exclusion criteria in the efficacy and safety studies of major COVID-19 vaccines. The U.S. Centers for Disease Control and Prevention recently included pregnancy as a risk factor for severe COVID-19 infection, although the absolute risk is low. Previous experience in pregnant women with mRNA vaccines is lacking despite such vaccines not using live viruses, being unable to cause disease, not interacting with an individual's DNA, and being unable to cause genetic mutations. In addition, previous studies in animals have not revealed any safety issues with such vaccine types for female reproduction or fetal development. Vaccine-induced antibody titers were equivalent in pregnant and lactating women versus non-pregnant women. Given the data on increased mortality and morbidity associated with COVID-19 during pregnancy, it may be unethical to withhold vaccinations based on a theoretical risk and a lack of clinical research in this population. Additionally, a careful review of the vaccination recommendations for pregnant women by the academic community and government through additional efficacy and safety studies tailored to the situation in Korea is needed.
Digital Companion Choice to Support Teachers’ Stress Self-management: Systematic Approach Through Taxonomy Creation
Authors: Manning Julia B , Blandford Ann , Edbrooke-Childs Julian
Published: November 2021

Background

There are thousands of digital companions designed for emotional well-being and stress, including websites, wearables, and smartphone apps. Although public evaluation frameworks and ratings exist, they do not facilitate digital companion choice based on contextual or individual information, such as occupation or personal management strategies.

Objective

The aim of this study is to establish a process for creating a taxonomy to support systematic choice of digital companions for teachers’ stress self-management.

Methods

We used a 4-step study design. In step 1, we identified the dimension of stress self-management and strategic classifications. In step 2, we identified the dimension of the digital techniques and conceptual descriptions. In step 3, we created 6 criteria for the inclusion of digital companions. In step 4, we used the taxonomy framework created by steps 1 and 2 and populated it with digital companions for stress self-management, as identified in step 3.

Results

First, in the dimension of stress self-management, we identified four classes of strategies: educational, physiological, cognitive, and social. Second, in the digital techniques dimension, we derived four conceptual descriptions for the digital companions’ mechanisms of action: fostering reflection, suggesting treatment, peer-to-peer support, and entertainment. Third, we created six criteria for digital companion inclusion in the taxonomy: suitability, availability, evaluation, security, validity, and cost. Using the taxonomy framework and criteria, we populated it with digital companions for stress management ahead of presentation to teachers in a stress study workshop.

Conclusions

The elements of our approach can be generalized as principles for the creation of taxonomies for other occupations or conditions. Taxonomies such as this could be a valuable resource for individuals to understand which digital companion could be of help in their personal context.
Clinical application of interactive monitoring of indicators of health in professional dancers (Preprint)
Authors: Keay Nicola , Lanfear Martin , Francis Gavin
Published: November 2021

BACKGROUND

Dancers can be at risk of developing intentional and/or unintentional relative energy deficiency in sport (RED-S). Early identification of those at risk is important in prevention.

OBJECTIVE

The purpose of this study was to assess the effectiveness of interactive monitoring of professional dancer health with a variety of subjective and objective monitoring methods and delivering swift personalised clinical advice.

METHODS

Dancers from a ballet company completed a published, online dance-specific health questionnaire. Over the study period, dancers recorded wellbeing and training metrics, with menstrual cycle tracking and capillary blood testing for the recognised indicators of low energy availability. At regular, virtual clinical discussions with each dancer, findings were discussed and personalised advice given.

RESULTS

Twenty dancers participated in the study (mean age 26.2 years, SD 3.7), comprising 14 females (mean age 25.5 years, SD 3.7) and 6 males (mean age 27.7 years, SD 2.4). Ten of the female and all the male dancers recorded positive scores on the dance health questionnaire, suggesting a low risk of relative energy deficiency in sport (RED-S). Two female dancers were taking hormonal contraception. Apart from one, all female dancers not on hormonal contraception reported current eumenorrhoeic status. Blood testing confirmed the low risk of insufficient energy availability across the group, apart from female dancers with negative questionnaire scores. The initiative of monitoring menstrual cycles and on demand virtual clinical support was well received by dancers, healthcare and artistic staff.

CONCLUSIONS

Multimodal monitoring facilitated delivery of prompt personalised clinical medical feedback specific for dance. This interactive strategy permitted the early identification and swift management of emergent clinical issues. Dancers highly rated the new monitoring modalities and opportunity to discuss health and well-being, in confidence, with a doctor conversant in dance.
Statistical partitioning of Ki-67 distribution can refine Molecular Classifica-tion of invasive Breast Carcinoma (Preprint)
Authors: Laila Akhouayri , Regragui Meriem , benayad samira , Bennani Guebessi Nisrine , Marnissi Farida , chiorino giovanna , karkouri mehdi
Published: November 2021

BACKGROUND

Breast carcinoma is one of the most common histological types of Breast Cancer, exploring a new approach that allows to do a quantitative description in order to characterize its heterogeneity and refine its classification is one of the main interests for pathologists.

OBJECTIVE

The purpose of our study is to explore further statistically significant subdivisions beyond breast cancer molecular classification that is routinely established in pathology departments.

METHODS

We conducted a 5-year retrospective study on 1266 invasive breast carcinomas of moroccan pa-tients, collected at the Pathology Department of Ibn-Rochd University Hospital in Casablanca, and followed at King MohammedVI National Centre for the Treatment of Cancers. We elaborated an Estimation-Maximization clustering, based on the main Breast cancer prognosis biomarkers: Ki-67, HER2, oestrogen and progesterone receptors, evaluated by Immunohistochemistry.

RESULTS

Each molecular subgroup could be partitioned into two further subdivisions: Cluster1, with average Ki-67 of 16.26%(±11.9) across all molecular subgroups and higher frequency within luminal sub-groups, and Cluster2, with average Ki-67 of 68.8%(±18) across all molecular subgroups; and higher frequency in HER2 as well as in triple negative subgroups. Overall Survival of the two clusters was significantly different, with 5-year rates of 52 and 37 months for Cluster1 and Cluster2, respectively (p=0.000001). Moreover, patient survival within the same molecular subgroup varied remarkably depending on cluster membership. Three independent datasets (Algerian, TCGA-BRCA and METABRIC) were also analysed to assess the reproducibility of this new “2-clusters partition” through several clustering methods and validation measures. Two different al-gorithms to evaluate the prognostic importance, VSURF and MinimalDepth, confirmed that this new subdivision is able to predict patient survival better than several histoprognostic features.

CONCLUSIONS

Our results highlight a new refinement of the breast cancer molecular classification and provide a simple and improved way to classify tumors that could be applied in low to medium income countries. This is the first study of its kind addressed in an African context.
A Web-Based Communication Tool for Postoperative Follow-up and Pain Assessment at Home After Primary Knee Arthroplasty: Feasibility and Usability Study (Preprint)
Authors: Rian Torbjørn , Sand Kari , Skogvoll Eirik , Klepstad Pål , Wik Tina S
Published: November 2021

BACKGROUND

We report the use of an electronic tool, Eir (Eir Solutions AS, Norway), for symptom registration at home after knee arthroplasty. This electronic tool was used in a randomized controlled trial (RCT) comparing 3 different analgesic regimens with respect to postoperative pain and side effects.

OBJECTIVE

The aim of this substudy was to investigate this electronic tool for symptom registrations at home with respect to usability (ie, how easy it was to use) and feasibility (ie, how well the tool served its purpose).

METHODS

To assess the tool's usability, all participants were invited to fill out the 10-item System Usability Scale (SUS) after using the tool for 8 days. To assess feasibility, data regarding the participants' ability to use the tool with or without assistance or reminders were collected qualitatively on a daily basis during the study period.

RESULTS

A total of 134 patients completed the RCT. Data concerning feasibility of the web-based tool were collected from all 134 patients. The SUS was completed by 119 of the 134 patients; 70.2% (94/134) of the patients managed to use the tool at home without any technical support. All technical challenges were related to the login procedure or internet access. The mean SUS score was 89.6 (median 92.5; range 22.5-100).

CONCLUSIONS

This study showed high feasibility and high usability of the Eir web tool. The received reports gave the necessary information needed for both research data and clinical follow-up.

CLINICALTRIAL

ClinicalTrials.gov NCT02604446; https://www.clinicaltrials.gov/ct2/show/NCT02604446
High Pass Filter Application to Reduce Voice Communication Delays on IP Phones
Authors: Atmadja Martono Dwi
Published: November 2021

Abstract: VoIP technology is equipped with several functions, namely, the signalling function, meaning the VoIP is in charge of receiving the network from the caller, after which the conversation delivered. This technology is capable to pass voice traffic in the form of packets over an IP network. Packets of sound undergo a long process or delay to get to the destination it can damage the voice’s quality being heard. It happened because there is continuous delay in the communication between IP phone set on VoIP technology that causes echo in the receiver’s voice. Echo can occur during communication with IP phone set with average delay capacity above 5ms. The delay on the delivery and reception as in the results of communication between telephones can be adjusted for sound frequency of 300 Hz to 1000 Hz as a cut off by adding High Pass Filter (HPF) application. HPF filter application is able to stabilize the amplitude of about -21 dBm from the set of transmission test on the receiver when there is weakening at low frequencies, but when the frequency is raised to 1500-2250 Hz the amplitude strengthens to -12,2 dBm or increases the value of about 8.8 dB. Meanwhile, for the lower frequency such as 300 – 950 Hz, the filter would not pass it since the frequency is designed to be cut-off at 1000 Hz. The value of delay is narrower to 0.08ms by HPF application at the frequency of sound upper limit received by any 1000-3400 Hz telephone set. Keywords: VoIP technology, echo cancelling, HPF filter, delay, voice quality
The Initial Stage of Developing Translation Competence
Authors: Isroilovna Absamadova Munira
Published: November 2021

Abstract: The article outlines the basic principles of teaching translation in the professional field of communication. The main focus is on the formation of basic skills in translation, allowing students to competently carry out the main stages of work on the text. Various methods of teaching professional translation techniques are analyzed. Particular attention is paid to working with dictionaries and reference books. Keywords: translation, translation studies, competence-based approach, translation competence, speech communication, translation transformation.
Improving the hygiene of jamu sellers in Malang through the provision of appropriate technology
Authors: Nurwidodo N. , Mulyono M. , Fauzi Ahmad
Published: November 2021

Jamu (herbal medicine) is included in traditional health drinks that its processing is often less hygienic. The purpose of this community service program is to improve the cleanliness of the herbal medicine-making process in the herbal medicine group in Malang through the provision of hygienic herbal medicine processing machines. Community service activities were carried out in 2018 by involving herbal medicine groups in Tegalgondo and Jetis Villages, Malang. The community service activities included analyzing the conditions and needs of partners, designing herbal medicine machines as needed, as well as assisting the use of machines. The implementation methods in this service program were discussion and training. The result of this service activity was an increase in partner knowledge regarding the importance of hygiene and the use of appropriate technology in herbal medicine processing. After the training was carried out, service partners began to be moved to process jamu more hygienically. Furthermore, assistance and technology-based marketing training activities also need to be carried out.
Improving teacher quality through classroom action research
Authors: Amalia Nur , Wilis Fitni
Published: November 2021

Classroom Action Research Training for Aisyiyah PAUD Central Java Teachers to Improve the Quality of Learning delivered by the Principal and Teacher Training of PAUD 'Aisyiyah PWA Central Java, this activity aims to: 1) instill awareness in PAUD 'Aisyiyah teachers on the importance of Classroom Action Research 2) improve skills prepare proposals for Classroom Action Research 3) provide assistance related to Classroom Action Research, 4) train teachers to be able to provide treatment to the subjects studied, so that they experience positive changes. The methods used in this training are presentations, discussions, case studies. This training activity was attended by 142 teachers from PAUD 'Aisyiyah in Central Java. The results of the service are theoretically successful, this can be seen from the enthusiasm of the training participants who actively ask questions about the problems they encounter related to the steps of preparing the CAR proposal, but judging from the practice of preparing the proposal the results have not been satisfactory, because only 15% of participants can prepare a CAR proposal properly. and 33% is considered sufficient, while 52% of participants have not succeeded in compiling a CAR proposal. It is not easy to write CAR, it requires independent effort training from the teacher concerned to solve the problems faced in PBM. In general, PAUD 'Aisyiyah Central Java teachers need further assistance in writing Classroom Action Research.
Pengaruh pertumbuhan ekonomi dan tingkat pendidikan terhadap kemiskinan dengan pengangguran sebagai variabel intervening di Provinsi Jambi 2004-2018
Authors: Alwi Ahmad Afwan , Syaparuddin Syaparuddin , Hardiani Hardiani
Published: November 2021

This research aims to determine the effect of economic growth and education level towards poverty, with unemployment as an intervening variable in Jambi Province from 2004-2018 data based. This type of research is quantitative, using secondary data taken from the Central Bureau of Statistics, such as economic growth data, education levels, unemployment, and poverty during 2004 - 2018. Data processing in this research used SPSS software. 22 and using Path Analysis as a test tools analysis. The results of this research are that there is no significant effect of economic growth and education levels toward unemployment. Still, a significant impact existed of economic growth toward poverty, and there is no significant effect from education toward poverty. There is a significant effect of unemployment on poverty. Unemployment is the intervening variable of economic growth toward poverty because the unemployment variable increases the impact on poverty. Besides, unemployment is not an intervening variable because it does not increase the effect of education level toward poverty.
Keywords: Economic growth, education level, unemployment, Poverty
Pengaruh belanja modal dan penanaman modal dalam negeri terhadap pertumbuhan ekonomi di Kabupaten/Kota Provinsi Jambi
Authors: Fitrah Haikal Redho , Syaparudin Syaparudin , Emilia Emilia
Published: November 2021

This study aims to: 1) analyze the development of Capital Expenditure, PMDN and Regency and City Economic Growth in Jambi Province; 2) To find out and analyze the effect of Capital Expenditures and Domestic Investment on the Regency and City Economic Growth in Jambi Province. The research analysis tool uses panel data regression analysis tools. Based on the regression test results, the data of the simultaneous data shows that capital expenditure and PMDN have a significant effect on the economic growth of regencies/cities in Jambi Province. While partially leading the two independent variables, only PMDN affects economic growth in Jambi Province districts/cities, while capital expenditure does not affect economic growth in Jambi Province districts/cities during 2011-2017.
Keywords: Capital expenditure, PMDN, Economic growth
Improving genetic counseling access for parents of newborns who screen positive for cystic fibrosis: consensus guidelines
Authors: Langfelder-Schwind Elinor , Raraigh Karen , Parad Richard
Published: November 2021

Introduction A risk associated with cystic fibrosis newborn screening
(CFNBS) is parental misunderstanding of genetic information generated by
the over 6,600 positive screens reported annually in the US. CFNBS
algorithms incorporating DNA analysis can generate genetic information
that requires clinical interpretation and has significance for the
newborn, parents, and other relatives. Engagement between CF care
centers and trained genetic counseling providers, such as licensed
and/or certified genetic counselors (GCs), is variable and limited in
providing information to CFNBS positive (CFNBS+) families. Methods Using
a modified Delphi process, a workgroup of CF experts developed
recommendations for engagement of genetic counseling services in CF care
centers where CFNBS+ diagnostic evaluations are performed. Statements
were assessed over three rounds of surveys, one face-to-face meeting,
and through public feedback. Results Seventeen statements achieved
>80% consensus (range: 82-100%). The workgroup affirmed
prior CFF policy statements recommending genetic counseling for parents
of infants with CFNBS+. The remaining statements addressed
infrastructure and logistics of genetic counseling services, including
defining appropriate training for genetic counseling providers and
counseling content, establishing a path to equal access to genetic
counseling providers across CF care centers, and setting a standard for
client-centered CFNBS genetic counseling that is respectful of diverse
patient needs and autonomy. Conclusions Implementation of
client-centered genetic counseling for CFNBS+ families in CF care
centers by providers with expertise in both CF and genetic counseling
will require efforts to further define core concepts, enhance education
of providers, and develop opportunities for access via telemedicine.
Long-term trends and drought: spatiotemporal variation in juvenile sex ratios of North American ducks
Authors: Ellis Sage , Lohman Madeleine , Sedinger James , Williams Perry , Riecke Thomas
Published: November 2021

Sex ratios affect population dynamics and individual fitness, and
changing sex ratios can be indicative of shifts in sex-specific survival
at different life stages. While climate- and landscape-change alter sex
ratios of wild bird populations, long-term, landscape scale assessments
of sex ratios are rare. Further, little work has been done to understand
changes in sex ratios in avian communities. In this manuscript, we
analyse long-term (1961-2015) data on five species of ducks across five
broad climatic regions of the United States to estimate the effects of
drought and long-term trends on the proportion of juvenile females
captured at banding. As waterfowl have a 1:1 sex ratio at hatch, we
interpret changes in sex ratios of captured juveniles as changes in
sex-specific survival rates during early life. Seven of twelve
species-region pairs exhibited evidence for long-term trends in the
proportion of juvenile females at banding. The proportion of juvenile
females at banding increased for duck populations in the western United
States and typically declined for duck populations in the eastern United
States. We only observed evidence for an effect of drought in two of the
twelve species-region pairs, where the proportion of females declined
during drought. As changes to North American landscapes and climate
continue and intensify, we expect continued changes in sex-specific
juvenile survival rates. More broadly, we encourage further research
examining the mechanisms underlying long-term trends in juvenile sex
ratios in avian communities.
Mathematical model of solute transfer in a permeable channel with effect of variable viscosity
Authors: Merugu Varunkumar
Published: November 2021

This paper describes a mathematical model of solute transfer in fluid
flow across a permeable channel with variable viscosity, with
applications to glomerular capillary blood flow. Solute transfer through
the glomerular capillary wall is controlled by the difference in
transcapillary hydrostatic pressure and the analogous difference in
colloid osmotic pressure (Starling’s law). Using appropriate analytical
and numerical approaches, the solutions of coupled equations regulating
fluid flow and solute transport are found. The current study’s
hydrostatic and osmotic pressure curves are qualitatively in excellent
agreement with the experimental data. The effects of variable viscosity
on velocity profiles, concentration profiles, and total solute clearance
are seen to be substantial, and the findings are graphically depicted.