bluuebunny/crossref_metadata_2025 huggingface dataset:
Charge Carrier Collection Losses in Lead‐Halide Perovskite Solar Cells
Authors: Akel Samah , Wang Yueming , Yan Genghua , Rau Uwe , Kirchartz Thomas
Published: October 2024

The collection of photogenerated charges in halide perovskite solar cells depends on the thickness of the absorber layer, with larger thicknesses leading to a reduced collection efficiency. This observation has traditionally been associated with insufficiently high electron and hole diffusion lengths in the absorber layers. However, it is shown that in the presence of low‐mobility contact layers, charge collection can be thickness‐dependent, even if the absorber layer has infinite mobility. Here, analytical equations are derived for the thickness dependence of charge collection losses in situations where recombination is bulk or interface‐limited and show how to relate these equations to voltage‐dependent photoluminescence data. The analytical equations are compared to experimental data and numerical simulations and it is observed that experimental data on triple‐cation perovskite devices with different thicknesses approximately follows the case, where bulk recombination dominates.
Decoupling the Failure Mechanism of Li‐Rich Layered Oxide Cathode During High‐Temperature Storage in Pouch‐Type Full‐Cell: A Practical Concern on Anionic Redox Reaction
Authors: Zhang Baodan , Zhang Kang , Wu Xiaohong , Zheng Qizheng , Luo Haiyan , Zhang Haitang , Chen Yilong , Zhou Shiyuan , Zhu Yuanlong , Yin Jianhua , Zou Yeguo , Liao Hong‐Gang , Jiao Wen , Liu Na , Qin Yaru , Zhang Bin‐Wei , Shen Chongheng , Qiao Yu , Sun Shi‐Gang
Published: October 2024

In addressing the global climate crisis, the energy storage performance of Li‐ion batteries (LIBs) under extreme conditions, particularly for high‐energy‐density Li‐rich layered oxide (LRLO) cathode, is of the essence. Despite numerous researches into the mechanisms and optimization of LRLO cathodes under ideal moderate environment, there is a dearth of case studies on their practical/harsh working environments (e.g., pouch‐type full‐cell, high‐temperature storage), which is a critical aspect for the safety and commercial application. In this study, using pouch‐type full‐cells as prototype investigation target, the study finds the cell assembled with LRLO cathode present severer voltage decay than typical NCM layered cathode after high‐temperature storage. Further decoupling elucidates the primary failure mechanism is the over‐activation of lattice oxidized oxygen (aggravate by high‐temperature storage) and subsequent escape of oxidized oxygen species (On−), which disrupts transition metal (TM) coordination and exacerbates electrolyte decomposition, leading to severe TM dissolution, interfacial film reconstruction, and harmful shuttle effects. These chain behaviors upon high‐temperature storage significantly influence the stability of both electrodes, causing substantial voltage decay and lithium loss, which accelerates full‐cell failure. Although the anionic redox reaction can bring additional energy, but the escape of metastable On− species would introduce new concerns in practical cell working conditions.
Electrical Tissue Adhesives for Strain‐Insensitive In‐situ Biosensing
Authors: Wong Tsz Hung , Liu Jiabin , Cheng Yijie , Xie Yilin , Anway Camryn , Lu Ruihao , Ye Chuwei , Yu Zhaohan , Wang Yuan , Liu Xinyue , Lin Shaoting
Published: October 2024

In‐situ biosensing, a rapidly evolving field that focuses on the development of biosensors capable of on‐site detection of biomolecules directly from local tissue regions, holds the potential to revolutionize medicine through real‐time monitoring, personalized diagnosis, and targeted therapies. However, interfacing rigid, nonstretchable biosensors with soft, deformable tissues presents significant challenges due to their fundamentally contradictory properties. Herein, an electrical tissue adhesive featuring an entangled adhesive polymer network interpenetrated with a sacrificial dissipative polymer network is developed, which can rapidly and robustly adhere electrochemical biosensors with biological tissues, enabling strain‐insensitive physiological monitoring. The electrical tissue adhesive achieves a high fracture toughness of up to 3000 J m−2, a low Young's modulus of around 20 kPa, superior stretchability up to 15 times its initial length, and an overall biosensor‐tissue interfacial toughness of up to 500 J m−2. Using an electrochemical glucose sensor as one example, it is demonstrated that the electrical tissue adhesive can maintain resilient glucose sensing under various stress states and stretch levels. Additionally, the application of the electrical tissue adhesive for in‐situ monitoring of exercise and diet in subjects with various BMIs is demonstrated by measuring glucose concentration in sweat.
Association Between Early‐Life and Premorbid Measurements of Body Composition and Risk of Motor Neuron Disease: A Prospective Cohort Study in the UK Biobank
Authors: Joyce Emily E. , Xu Shishi , Ingre Caroline , Potenza Rosa Luisa , Seitz Christina , Yang Huazhen , Zeng Yu , Song Huan , Fang Fang
Published: October 2024

Objective

The objective of this study was to investigate the association between developmental and premorbid body composition measurements and the risk of motor neuron disease (MND).

Methods

We performed a cohort study in the UK Biobank to assess the association of developmental body metrics and premorbid body composition measures (using 28 measurements and 7 patterns of body composition) with the risk of MND. Among participants with longitudinal measures, we compared the changes in body composition over time between individuals who later developed MND and those who remained free of MND.

Results

Among the 412,691 individuals included in this study, 549 people received an MND diagnosis during the follow‐up visit. Higher birth weight was associated with an increased risk of MND among individuals born over 4 kg (hazard ratio [HR] per kg increase = 2.21, 95% confidence interval [CI] = 1.38–3.55), and taller adult height was associated with an increased risk of MND (HR per 5 cm increase = 1.10, 95% CI = 1.03–1.17). We observed that measures of elevated fat mass were associated with a lower risk of MND more than 5 years before diagnosis. A higher “leg‐dominant fat distribution” pattern was associated with an increased risk whereas higher “muscle strength” was associated with a reduced risk of MND 5 years before diagnosis. Longitudinal analyses indicated a faster decline in measures of fat mass and muscle strength, as well as a shift in fat distribution from arm to leg dominant, among individuals who later developed MND, compared with others.

Interpretation

Body composition at early and middle age may be indicative of the risk of MND development. ANN NEUROL 2025;97:259–269
Electrothermal Conversion of Methane to Methanol at Room Temperature with Phosphotungstic Acid
Authors: Chang Jinquan , Wang Sikai , Hülsey Max J. , Zhang Sheng , Nee Lou Shi , Ma Xinbin , Yan Ning
Published: October 2024

Traditional methods for the aerobic oxidation of methane to methanol frequently require the use of noble metal catalysts or flammable H2‐O2 mixtures. While electrochemical methods enhance safety and may avoid the use of noble metals, these processes suffer from low yields due to limited current density and/or low selectivity. Here, we design an electrothermal process to conduct aerobic oxidation of methane to methanol at room temperature using phosphotungstic acid (PTA) as a redox mediator. When electrochemically reduced, PTA activates methane with O2 to produce methanol selectively. The optimum productivity reaches 29.45
with approximately 20.3 % overall electron yield. Under continuous operation, we achieved 19.90
catalytic activity, over 74.3 % methanol selectivity, and 10 hours durability. This approach leverages reduced PTA to initiate thermal catalysis in solution phase, addressing slow methane oxidation kinetics and preventing overoxidations on electrode surfaces. The current density towards methanol production increased over 40 times compared with direct electrochemical processes. The in situ generated hydroxyl radical, from the reaction of reduced PTA and oxygen, plays an important role in the methane conversion. This study demonstrates reduced polyoxotungstate as a viable platform to integrate thermo‐ and electrochemical methane oxidation at ambient conditions.
Topology of Gemini‐shaped Hexagonal Heterojunction for Efficient Stereoconvergent Transformation via Dynamic Kinetic Resolution
Authors: Mou Qi , Han Qingqing , Tai Hulin , Fang Yajun , Kim Young Yong , Mu Yingxiao , Chen Shuixia , Huang Liping , Zhang Yi , Jin Long Yi , Huang Zhegang , Lee Myongsoo
Published: October 2024

Despite recent advances in the combination of kinetic resolution and racemization for efficient stereoconvergent transformation, the poor stability and limited reaction activities of the products restrict their wide application in industrial production. To overcome these problems, Gemini‐shaped hexagons with para‐heterojunctions for one‐dimensional and two‐dimensional supramolecular polymers were designed via hydrogen‐bonding adhesion by racemization catalyst 1 and kinetic resolution 2 in this work. The polymers from the assembly of Gemini‐shaped hexagons exhibit rapid catalytic behaviour with efficient selectivity for the desired configuration in the synthesis of tertiary alcohols with contiguous stereocenters through dynamic kinetic resolution for the nanoscale heterojunctions of dissimilar catalysts. Among them, the developed 2D polymers gave outstanding enantioselectivities and diastereoselectivities (>99 % ee, 20 : 1 dr) through the cooperation of adjacent dissimilar catalysts. The heterojunctions varying dimensions and distances of dissimilar catalysts provide new insight for increasing the enantioselectivity of chiral organocatalysts.
Carbon Nanocage Supported Asymmetrically Coordinated Nickle Single‐Atom for Enhanced CO2 Electroreduction in Membrane Electrode Assembly
Authors: Lin Yingxi , Xia Chenfeng , Zhu Zhaozhao , Wang Junjie , Niu Huiting , Gong Shuning , Li Zhao , Yang Na , Song Chen Jun , Wu Rui , Xia Bao Yu
Published: October 2024

Designing efficient catalysts for operating CO2 electroreduction in membrane electrode assembly (MEA) faces significant obstacles. Herein, we propose an asymmetrically coordinated Ni single‐atom catalyst featuring axial Br coordination at NiN4Br sites anchoring onto hollow Br/N co‐doped carbon nanocages, achieved through a NaBr‐assisted confined‐pyrolysis strategy. The Ni‐NBr‐C catalyst exhibits a high CO Faradaic efficiency (FECO>97 %) over the current density range of 50 to 350 mA cm−2 in the MEA device. Furthermore, Ni‐NBr‐C shows a stable cell voltage of 2.66±0.2 V while delivering a large current density of 350 mA cm−2 over an 85‐hour long‐term operation, demonstrating its potential for industrial‐scale applications. Advanced characterization techniques and theoretical calculations reveal that the coordination and doping of Br not only enhance the intrinsic activity but also highlight that the unique pore structure improves mass transfer efficiency.
Evaluation of Antimicrobial, Antitumor, Antioxidant Activities, and Molecular Docking Studies of Some Co(II), Cu(II), Mn(II), Ni(II), Pd(II), and Pt(II) Complexes With a Schiff Base Derived From 2‐Chloro‐5‐(trifluoromethyl)aniline
Authors: Pahonțu Elena , Dinu Pîrvu Cristina Elena , Vișan Diana Carolina , Socea Laura Ileana , Apostol Teodora Venera , Oprean Camelia , Păunescu Virgil , Ungurianu Anca , Margină Denisa Marilena , Codiță Irina , Dumitrescu Silviu , Drăgănescu Doina , Lupașcu Gina
Published: October 2024

The antimicrobial, antitumor and antioxidant potential of Co(II), Cu(II), Mn(II), Ni(II), Pd(II), and Pt(II) complexes with 2‐(((2‐chloro‐5‐(trifluoromethyl)phenyl)imino)methyl)phenol HL ligand was investigated. A molecular docking study was carried out to estimate the predicted binding affinity of the compounds to protein targets involved in proliferative and bacterial activities. Fluorescence quenching studies and synchronous spectra were used to examine the metal complexes interactions with CT‐DNA and BSA protein. The DNA binding study have revealed that the complexes are capable of binding with DNA via intercalative mode. The antimicrobial activity of the ligand and metal complexes was studied against three Gram‐positive bacteria, two Gram‐negative bacteria, and three strains of fungi. The best antibacterial effect was demonstrated by the Pt(II) complex on the Staphylococcus aureus strain, and as for the inhibitory effect on fungi, it was stronger on the Candida albicans strain after treatment with the Co(II) complex. The in vitro antiproliferative activity of ligand and complexes was analyzed using MTT, Annexin V/PI, and cell cycle assays. The in vitro results showed that, except for Pd(II) complex, where slight effects were observed, the MCF‐7 line was resistant to the activity of the complexes. In the case of A549 cells, Cu(II) and Pd(II) complexes showed a dose‐dependent antitumor activity, confirmed by both the Alamar blue and the Annexin V/PI analysis. Finally, the antioxidant activity of the compounds was examined by ABTS and DPPH methods. Antioxidant investigation showed that the Ni(II) complex possesses a remarkable ability to trap the cation of the ABTS+ radical (IC50 value 9.35 μM).
Effect of the Introduction of ZnII and CdII Ions on EuIII and TbIII Emission in M2Ln2 Heterometallic Molecules With 2‐Furoic Acid Anions
Authors: Shmelev Maxim A. , Melnikov Stanislav N. , Nikolaevskii Stanislav A. , Kiraev Salauat R. , Ananyev Ivan V. , Nelyubina Yulia V. , Varaksina Evgenia A. , Korshunov Vladislav M. , Taydakov Ilya V. , Goloveshkin Alexander S. , Gogoleva Natalia V. , Sidorov Alexey A. , Eremenko Igor L. , Kiskin Mikhail A.
Published: October 2024

Heterometallic d‐4f coordination complexes are of paramount interest in modern coordination chemistry because of their potential applications in organic light‐emitting devices and spintronic materials. Here we report the synthesis and thorough investigation of Ln and MLn (M = Zn, Cd; Ln = Sm, Eu, Gd, Tb) molecular complexes based on 2‐furancarboxylic acid anion (Hfur): [Ln2(NO3)2(fur)4(DME)2] (Ln = Eu, Gd, Tb; DME is dimethoxyethane) and [M2Ln2(NO3)2(fur)8(bpy)2] (M = Zn, Cd; Ln = Eu, Gd, Tb, Sm; bpy is 2,2′‐bipyridyl). The structure and isostructural nature of compounds were determined based on the single‐crystal and powder X‐ray diffraction data. The photophysical properties of the obtained compounds were studied in detail: The energies of the triplet levels of the furoate anion and d‐blocks {M(fur)2(bpy)} (M = Zn, Cd), the relaxation times of the excited states, and the quantum yields were determined. Critical step from Ln complexes to ZnLn and CdLn (Ln = Eu, Tb) is accompanied by an increase in quantum yields, which correlates with a change in the energy of the triplet level of the aromatic part of the complexes and with the results of quantum chemical calculations indicating different schemes for the origination of triplet levels in MLn compounds.
Preparation of low‐temperature self‐crosslinking acrylic resin and its performance research
Authors: Xin Hua , Zhang Peiyi , Xu Yiyi , Gao Bo , Yuan Luoqi , Wei Minli
Published: October 2024

Acrylic resin, as a common coating and adhesive, possesses excellent heat resistance, weather resistance, and is inexpensive, making it widely used in industries related to automotive, construction, electronics, fabrics, and other sectors essential to our daily life. Traditional acrylic resin not only pollutes the environment but also poses certain health risks. Therefore, we studied the synthesis of a low‐temperature self‐crosslinking acrylic emulsions were synthesized by free radical solution polymerization using methyl methacrylate (MMA), butyl acrylate (BA), acrylic acid (AA), diacetone acrylamide (DAAM), hydroxypropyl acrylate (HPA), epoxy resin (E‐51) as the monomers, vinyltriethoxysilane (A‐51) as the coupling agent, and adipic dihydrazide (ADH) as the cross‐linking agent. This water‐based acrylic resin undergoes a crosslinking reaction between the carbonyl group of DAAM and the hydrazide group of ADH, substantially improved the drying speed and adhesion compared to unmodified versions, and also improved the thermal stability. The contact angle of the film increased from 72.8° to 86.9° with the increase of the degree of cross‐linking, and the mechanical properties were improved by 60%. This study provides a suitable formulation for preparing water‐based acrylic resins with superior performance.
A hydrogel sensor based on conic baston structure
Authors: Qi Jian , Yin Lukui , Zhang Guoliang , Li Yang , Zheng Shuxian , Gao Shuo , Huang Dake , Qi HouJun
Published: October 2024

Resistive flexible pressure sensors are extensively employed in wearable devices owing to their wide operational range and straightforward construction. This study presents a conic bastion‐structured sensor microunit to improve the sensor sensitivity. The base hydrogel is synthesized using acrylamide (AM), with Mg2+ and Na+ acting as conductive ions. The sensor is fabricated using digital light processing (DLP) 3D printing technology and is subjected to experimental evaluation. The findings indicate that the hydrogel sensor with a 50 wt% AM composition demonstrates enhanced mechanical strength and conductive properties, achieving a peak sensitivity of 0.534 kPa−1 within a pressure range of 0–0.8 kPa. Furthermore, the sensor exhibits favorable response characteristics (30 ms) and recovery characteristics (40 ms), along with stability. The proposed sensor is suitable for wearable devices and live joint angle detection. Additionally, the “handwriting fingerprint” pattern recognition and document verification proposed in this article make it applicable in scenarios, such as banking, notarization, and other handwriting and seal verification contexts.
An open‐source LED lamp for use with the LI‐6800 photosynthesis system
Authors: Vélez‐Ramírez Aarón I. , Moreno Juan de Dios , Pérez‐Guerrero Uriel G. , Juarez Antonio M. , Castillo‐Arriaga Hector , Vázquez‐Medrano Josefina , Hernández‐Morales Ilane
Published: October 2024

Premise

Controlling light flux density during carbon dioxide assimilation measurements is essential in photosynthesis research. Commercial lamps are expensive and are based on monochromatic light‐emitting diodes (LEDs), which deviate significantly in their spectral distribution compared to sunlight.

Methods and Results

Using LED‐emitted white light with a color temperature similar to sunlight, we developed a cost‐effective lamp compatible with the LI‐6800 Portable Photosynthesis System. When coupled with customized software, the lamp can be controlled via the LI‐6800 console by a user or Python scripts. Testing and calibration show that the lamp meets the quality needed to estimate photosynthesis parameters.

Conclusions

The lamp can be built using a basic electronics lab and a 3D printer. Calibration instructions are supplied and only require equipment commonly available at plant science laboratories. The lamp is a cost‐effective alternative to perform photosynthesis research coupled with the popular LI‐6800 photosynthesis measuring system.
Renewable Energy Investments, Support Schemes and the Dirty Option
Authors: De Giovanni Domenico , Iakimova Elena
Published: October 2024

In a real options framework, we analyze the behavior of a large energy producer who can invest in a portfolio of Renewable Energy Source (RES) and dirty energy source. Competitive fuel prices challenge the investments in RES. Given a budget constraint, the agent allocates the optimal capacities of both energy instalments and selects the optimal investment time. We use the model to compare the effectiveness of classical support schemes such as Feed‐in Tariffs or Green Certificate with respect to forms of taxation of dirty technology such as Carbon Taxes or Carbon Permits. This paper proposes a conceptual framework and qualitative analysis to understand which support system enhances the attractiveness of renewable energy investments.
Corn biomass as a feedstock for biorefinery: a bibliometric analysis of research on bioenergy, biofuel and value‐added products
Authors: da Rosa Rafael Gabriel , Ferreira Vanessa Cosme , Barroso Tiago Linhares Cruz Tabosa , Castro Luiz Eduardo Nochi , Forster‐Carneiro Tânia
Published: October 2024

Limited research has been dedicated to exploring the potential reuse and creation of value‐added products from corn stover. Existing gaps in current research underscore the need for waste biorefineries that adhere to the principles of a circular bioeconomy to maximize the value of corn stover. This review uses bibliometric analysis from the past decade to examine the potential and pathways for converting corn stover into energy and value‐added products within the biorefinery framework. The data were processed using the Web of Science® database and analyzed with the VosViewer® bibliometric software's, Bibliometrix package in R and Gephi, generating keyword‐based maps. A total of 2557 experimental articles and 30 reviews on corn stover research were analyzed. The bibliometric study revealed that the primary research focuses on pretreatment technologies for converting corn stover into value‐added products, bioenergy and biofuels. The main technologies employed include acid, alkaline and enzymatic hydrolysis, as well as torrefaction anaerobic digestion and steam explosion. The pretreatment processes yield sugars, xylooligosaccharides and organic acids. Additionally, the studies explored the use of corn stover biochar for soil remediation and adsorption processes. This review aims to enhance the understanding of technological pathways explored in previous research, contributing to the evaluation of sustainable processes for utilizing corn stover byproducts. Ultimately, it promotes environmentally conscious agroindustry practices that align with circular economy principles and sustainable development.
NonImmune hemolytic anemia secondary to vitamin B12 deficiency—A case report
Authors: Tamang Ashish , Sapkota Prakash , Gurung Ram Bahadur , Subedi Abiral , Sachdeva Chhavi
Published: October 2024

Key Clinical Message

This case report emphasizes the crucial need to include vitamin B12 deficiency in the differential diagnosis of hemolytic anemia, despite its rarity as a presentation. The case illustrates that non‐immune hemolytic anemia can occur secondary to severe vitamin B12 deficiency, which can be effectively treated with vitamin B12 supplementation. Early recognition and comprehensive evaluation are essential for identifying this uncommon yet significant cause of hemolysis, ensuring prompt and appropriate treatment to improve patient outcomes.
Toward a Dynamic Allocation Strategy for Deadline‐Oriented Resource and Job Management in HPC Systems
Authors: Linnert Barry , De Rose Cesar Augusto F. , Heiss Hans‐Ulrich
Published: October 2024

As high‐performance computing (HPC) becomes a tool used in many different workflows, quality of service (QoS) becomes increasingly important. In many cases, this includes the reliable execution of an HPC job and the generation of the results by a certain deadline. The resource and job management system (RJMS) or simply RMS is responsible for receiving the job requests and executing the jobs with a deadline‐oriented policy to support the workflows. In this article, we evaluate how well static resource management policies cope with deadline‐constrained HPC jobs and explore two variations of a dynamic policy in this context. As the Hilbert curve‐based approach used by the SLURM workload manager represents the state‐of‐the‐art in production environments, it was selected as one of the static allocation strategies. The Manhattan median approach as a second allocation strategy was introduced as a research work that aims to minimize the communication overhead of the parallel programs by providing compact partitions more than the Hilbert curve approach. In contrast to the static partitions provided by the Hilbert curve approach and the Manhattan median approach, the leak approach focuses on supporting dynamic runtime behavior of the jobs and assigning nodes of the HPC system on demand at runtime. Since the contiguous leak version also relies on a compact set of nodes, the noncontiguous leak can provide additional nodes at a greater distance from the nodes already used by the job. Our preliminary results clearly show that a dynamic policy is needed to meet the requirements of a modern deadline‐oriented RMS scenario.
Generation of Barcode‐Tagged Vibrio fischeri Deletion Strains and Barcode Sequencing (BarSeq) for Multiplex Strain Competitions
Authors: Burgos Hector L. , Mandel Mark J.
Published: October 2024

Vibrio fischeri is a model mutualist for studying molecular processes affecting microbial colonization of animal hosts. We present a detailed protocol for a barcode sequencing (BarSeq) approach that combines targeted gene deletion with short‐read sequencing technology to enable studies of mixed bacterial populations. This protocol includes wet lab steps to plan and produce the deletions, approaches to scale up mutant generation, protocols to prepare and conduct the strain competition, library preparation for sequencing on an Illumina iSeq 100 instrument, and data analysis with the barseq python package. Aspects of this protocol could be readily adapted for tagging wild‐type V. fischeri strains with a neutral barcode for examination of population dynamics or BarSeq analyses in other species. © 2024 The Author(s). Current Protocols published by Wiley Periodicals LLC.

Basic Protocol 1: Production of the erm‐bar DNA

Basic Protocol 2: Generation of a targeted and barcoded deletion strain of V. fischeri

Alternate Protocol: Parallel generation of multiple barcode‐tagged V. fischeri deletion strains

Basic Protocol 3: Setting up mixed populations of barcode‐tagged strains

Basic Protocol 4: Performing a competitive growth assay

Basic Protocol 5: Amplicon library preparation and equimolar pooling

Basic Protocol 6: Sequencing on Illumina iSeq 100

Basic Protocol 7: BarSeq data analysis
Improving Cover Crop Interseeding in Northern Climates
Authors: Darby Heather , Sanders Jeff
Published: October 2024

Extensive research has found that cover cropping can increase the overall health of agricultural systems by scavenging excess nutrients, increasing water infiltration, reducing surface runoff, increasing biodiversity, and building organic matter. Furthermore, cover cropping can help enhance the benefits of other farming practices such as no‐till planting, creating synergies that increase farm financial and environmental sustainability. In northern climates, there are significant challenges to establishing cover crops due to the short growing window following corn silage harvest. The authors of this article share their experiences, challenges, and successes of integrating cover crops into northern climates. Earn 0.5 CEUs in Crop Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
Effects of microRNA on the growth and targeted therapy response on lung cancer
Authors: Zhu Mengchen , Jiang Yi , Liu Lingshuang
Published: October 2024

Lung cancer represents a significant public health concern worldwide. Lung cancer typically receives a diagnosis at a late stage, leading to a generally unfavourable prognosis. Additionally, traditional treatments frequently fail in cases of metastatic lung cancer. However, targeted therapy has advanced considerably in the management of lung cancer, and overcoming drug resistance has emerged as a significant hurdle in achieving optimal treatment outcomes. As a result, there has been a new trend toward precision therapy for lung cancer based on changes at the molecular and genetic levels. On the other hand, for lung cancer, early diagnosis plays a crucial role in treatment and prognosis. Based on existing knowledge, we strongly believe that it is imperative to promptly identify innovative biomarkers. The emergence of microRNAs (miRNAs) provides new ideas. The expression profiles of miRNAs have been investigated using noninvasive blood samples to explore the regulatory mechanisms played by miRNAs during the progression and targeted therapy resistance of lung cancer. Due to the complexity of miRNA profiles, they may play the role of tumour suppressors or oncogenes. However, specific regulatory mechanisms are still a huge topic to be explored. In this Review, we summarize the latest research that has shed light on the potential regulatory mechanisms of miRNAs in driving lung cancer progression, their value for clinical application as biomarkers and their role in targeted therapy resistance.
Re‐Categorization and Risk of Malignancy of Atypical Effusions According to the International System for Reporting Serous Fluid Cytopathology (TIS): An Institutional Experience
Authors: Doğan Kutsal , Kurtulan Olcay , Onder Sevgen
Published: October 2024

Background

Serous effusion fluids serve as crucial cytological materials in diagnosing the underlying causes of fluid accumulation in various body cavities. The International System for Reporting Serous Fluid Cytopathology (TIS) outlined atypia of undetermined significance (AUS) and suspicious for malignancy (SFM) as two intermediate categories for atypical fluids.

Materials and Methods

In our study, cases diagnosed as “atypical” by an experienced cytopathologist in the Hacettepe University Department of Pathology, between 2014 and 2023, were re‐categorized according to TIS. The risk of malignancy (ROM) for AUS and SFM categories was calculated. Additionally, cases were re‐evaluated according to the 5‐tier categorical system by two observers with different level of experience.

Results

A total of 3501 effusion fluids were included in the study, evaluated between 2014 and 2023. 50.7% of the cases were male, and 49.3% were female. 55.2% of the cases were pleural fluid, 41.5% were peritoneal fluid, and 3.3% were pericardial fluid. Two hundred sixty five cases (7.6%) were non‐diagnostic, 2160 (61.7%) were negative for malignancy, 111 (3.2%) were AUS, 83 (2.4%) were SFM, and 883 (25.2%) were malignant (M). ROM calculated 27% for AUS, 49% for SFM 49%. The interobserver agreement for AUS was 46% with kappa value of 0.162, and 42% for SFM with kappa value of 0.188.

Conclusion

The differentiation of atypical cases into AUS and SFM is effective in determining the ROM. The interobserver agreement tends to be lower in intermediate categories compared to others, emphasizing the potential significance of clinical expertise in diagnosis.
Evidence to inform spatiotemporal management of a western Pacific Ocean tuna purse seine fishery
Authors: Gilman Eric , Chaloupka Milani , Posanau Nialangis , Hidalgo Marcelo , Pokajam Sylvester , Papaol Donald , Nanguromo Adrian , Poisson Francois
Published: October 2024

Fisheries can profoundly impact co‐occurring species exposed to incidental capture. Spatiotemporal fisheries management holds substantial potential to balance socioeconomic benefits with ecological costs to threatened bycatch species. This study estimated the effect of the spatial and temporal distribution of effort by a western Pacific Ocean tuna purse seine fishery on catch rates of target and at‐risk species by fitting spatially explicit generalized additive multilevel regression models within a Bayesian inference framework to observer data. Mean field prediction surfaces defined catch rate hotspots for tunas, silky sharks, rays, and whale sharks, informing the design of candidate area‐based management strategies. Due to limited sample sizes, odontocete and marine turtle catch rate geospatial patterns were summarized using simple 2D hexagonal binning. Effort could be focused in two areas within core fishing grounds to reduce overlap with hotspots for silky sharks, rays, and whale sharks without affecting target catch. Effort could be shifted outside of core fishing areas to zones with higher target tuna catch rates to reduce overlap with hotspots for at‐risk species. Sparse and small marine turtle and whale shark hotspots occurred across the fishing grounds. Results did not identify opportunities for temporally dynamic spatial management to balance target and at‐risk catch rates. Research on the economic and operational viability of alternative spatial management strategies is a priority. A small subset of sets had disproportionately large odontocete captures. Real‐time fleet communication, move‐on rules, and avoiding sets on dolphin schools might reduce odontocete catch rates. Managing set association type and mesh size present additional opportunities to balance catch rates of at‐risk and target species. Employing output controls that effectively constrain the fishery would alter the spatial management strategy to focus fishing within zones with the lowest ratio of at‐risk bycatch to target tuna catch. Findings inform the design of alternative spatial management strategies to avoid catch rate hotspots of at‐risk species without compromising the catch of principal market species.
Review on polymer electrolytes for lithium‐sulfurized polyacrylonitrile batteries
Authors: Zhang Yan , Wang Su , Li Chen , Wang Zhaokun , Ma Yue , Shi Xixi , Zhang Hongzhou , Song Dawei , Zhang Lianqi
Published: October 2024

Lithium‐sulfur (Li‐S) batteries are deemed as the next generation of energy storage devices due to high theoretical specific capacity (1675 mAh g−1) and energy density (2600 Wh kg−1). However, the commercial application has always been constrained by lithium polysulfide (LiPSs) shuttling effects and still has a long way to go. Sulfurized polyacrylonitrile (SPAN) is a promising alternative candidate to replace traditional sulfur cathode and is conducive to eliminating LiPSs by realizing “solid‐solid” direct conversion in conventional carbonate electrolytes. However, an over 25% irreversible capacity loss is exhibited inevitably in the first discharge process, the inherent structure of SPAN and the related reaction mechanism remain unclear. In this review, the structure characteristics and electrochemical behaviors of SPAN are summarized for better interpreting current knowledge and favoring the design of high performance materials. In the past few decades, many problems in traditional Li‐S batteries have been solved by improving electrolytes. Polymer electrolytes (PEs) have been widely used due to structural designability, multi‐functionality, exceptional chemical stability, and excellent processability. Surprisingly, the relevant researches on PEs compatible with SPAN remains limited currently. Therefore, the recent modification strategies of gel polymer electrolytes and solid polymer electrolytes in Li‐SPAN batteries are introduced in terms of Li+ transfer and interface engineering, the design principles are concluded, the specific challenges encountered by polymer‐based electrolytes are summarized and the instructive directions for future research on PEs are demonstrated, facilitating the commercialization of Li‐SPAN batteries.
Root puppet masters: Infauna shift trait‐productivity relationships in submerged aquatic vegetation communities
Authors: Angove Charlotte , Norkko Alf , Gustafsson Camilla
Published: October 2024

Submerged aquatic vegetation (SAV) growth can be limited by light and nutrient availability. Infauna are common inhabitants of SAV meadows. Their activity increases nutrient mobility, and they can positively affect plant growth, but we do not know their role in plant trait‐biomass production relationships. We approached this problem using a 15‐week in situ transplant experiment in the Baltic Sea with experimental additions of Macoma balthica, a sedentary bivalve, to experimental SAV communities. Experimental plant communities were tricultures with varying species composition, compiled from a pool of six different species, to create an experimental gradient of trait community weighted means that allowed us to detect changes more clearly in plant trait‐biomass production relationships in response to the M. balthica treatment. We evaluated the relationships between plant height, leaf area, maximum root length (MMRL), specific root length (SRL), and SAV biomass production, then compared M. balthica condition index (soft tissue biomass [WW, mg]/valve length [mm]) to plant community leaf tissue nutrient concentrations (N (%DW), δ15N). Community biomass production was significantly related to plant height in the control treatment, but this relationship was decoupled in the M. balthica treatment, where community biomass production was instead significantly related to MMRL and SRL. This suggested a shift in the predominant SAV growth strategy, from height‐related to root‐related community biomass production. Leaf tissue δ15N was significantly related to M. balthica condition index. The growth of one species, Potamogeton perfoliatus, was significantly inhibited by the M. balthica treatment. Our results show that infauna have an important role in the plant traits related to community biomass production, and they have the potential to shape plant community structure via selective influences on different plant species.
Of Clams and Clades: Genetic Diversity and Connectivity of Small Giant Clams (Tridacna maxima) in the Southern Pacific Ocean
Authors: Nevatte Ryan J. , Gillings Michael R. , Morejohn Kirby , Ainley Lara , Liggins Libby , Pratchett Morgan S. , Hoey Andrew S. , Doll Peter C. , Pasisi Brendon , Williamson Jane E.
Published: October 2024

Giant clams (Tridacna and Hippopus) are large marine bivalves occupying tropical and subtropical reefs in the Indo‐Pacific. Giant clam populations have declined in many areas of the Indo‐Pacific and continue to be threatened by harvesting and environmental change. The small giant clam (Tridacna maxima) occurs throughout the Indo‐Pacific and has been subject to several phylogeographic studies across its range. However, given its broad range, there are several areas where the genetic diversity and connectivity of T. maxima populations has not been characterised. Here, we analyse the mitochondrial marker cytochrome oxidase 1 (CO1) to examine the genetic diversity and connectivity of T. maxima in two regions: Australia's Coral Sea Marine Park and the Cook Islands. Samples were collected from 13 reefs within the Coral Sea Marine Park and ten islands within the Cook Islands archipelago. Tridacna maxima across the sampled region of the Coral Sea did not display any population structure, whereas significant population structure was detected for T. maxima within the Cook Islands. For the Cook Islands, most pairwise comparisons involving an island in the northern group (Manihiki) were significant, as were comparisons for Palmerston (a more centrally located island) and the southern islands, Rarotonga and Mangaia. Both regions displayed high haplotype diversities (> 0.90), indicating that they are important repositories of genetic diversity. Additional CO1 data from throughout T. maxima's distribution showed that the Coral Sea clams belonged to the clade occurring in the South‐Western Pacific Ocean, whilst those from the Cook Islands belonged to a unique clade found in the Central Pacific Ocean. This clade extended from Fiji in the west to French Polynesia in the east and the atolls of Palmyra and Tarawa (Kiribati) in the north. Our assessment of genetic diversity and population structure in these regions will assist with management decisions for the species.
Modeling the Current and Future Distribution of Indianthus virgatus (Roxb.) Suksathan & Borchs.: A Monotypic Plant Endemic to the Western Ghats‐Sri Lanka Biodiversity Hotspot
Authors: Vishnu Shreekara Bhat , Pandi Vivek , Madola Indrakheela , Gopallawa Bhathiya , Abraham Gija Anna , Gayathri Rajendiran , Yakandawala Deepthi , Muthusamy Annamalai
Published: October 2024

Species distribution modeling (SDM) is an essential tool in ecology and conservation for predicting species distributions based on species presence/absence data and environmental variables. The present study aimed to understand the distribution pattern and habitat suitability of Indianthus virgatus under current and future climate change scenarios (2050 and 2070) using MaxEnt (3.4.4) and Wallace Ecological Modeling (v2.1.2) tools. The study also intended to identify key environmental predictors of I. virgatus' distribution. Species occurrence data were collected from various sources, including herbarium (online and physical), field surveys, and online databases, yielding 105 unique locations in the Western Ghats (WG) of India and Sri Lanka. We used 19 bioclimatic variables and elevation data sourced from WorldClim for modeling. The MaxEnt and Wallace models showed excellent performance in predicting the distribution of I. virgatus, with area under the curve values of 0.958 (± 0.002) and 0.93, respectively. In MaxEnt modeling, Temperature Seasonality (bio4) was the most significant environmental parameter, followed by the Precipitation of the Coldest Quarter (bio19). In contrast, the Annual Mean Temperature (bio1), Temperature Seasonality (bio4), and Annual Precipitation (bio12) were among the key contributors in Wallace EcoMod. Both the models predicted relatively lesser areas in the species' distribution range as highly suitable habitats (HSH) in India and Sri Lanka. We found divergent trends in predicting I. virgatus distributions using MaxEnt and Wallace EcoMod, particularly for future projections. Nevertheless, both models predicted significant habitat loss under future climate change scenarios, especially under RCP85, with varying degrees of suitability across India and Sri Lanka. Overall, our findings on expected habitat loss under future climate change scenarios highlight the importance of conserving I. virgatus, which has already been declared critically endangered (CR) in Sri Lanka.
Temporal variability and predictability predict alpine plant community composition and distribution patterns
Authors: Reed William J. , Westmoreland Aaron J. , Suding Katharine N. , Doak Daniel F. , Bowman William D. , Emery Nancy C.
Published: October 2024

One of the most reliable features of natural systems is that they change through time. Theory predicts that temporally fluctuating conditions shape community composition, species distribution patterns, and life history variation, yet features of temporal variability are rarely incorporated into studies of species–environment associations. In this study, we evaluated how two components of temporal environmental variation—variability and predictability—impact plant community composition and species distribution patterns in the alpine tundra of the Southern Rocky Mountains in Colorado (USA). Using the Sensor Network Array at the Niwot Ridge Long‐Term Ecological Research site, we used in situ, high‐resolution temporal measurements of soil moisture and temperature from 13 locations (“nodes”) distributed throughout an alpine catchment to characterize the annual mean, variability, and predictability in these variables in each of four consecutive years. We combined these data with annual vegetation surveys at each node to evaluate whether variability over short (within‐day) and seasonal (2‐ to 4‐month) timescales could predict patterns in plant community composition, species distributions, and species abundances better than models that considered average annual conditions alone. We found that metrics for variability and predictability in soil moisture and soil temperature, at both daily and seasonal timescales, improved our ability to explain spatial variation in alpine plant community composition. Daily variability in soil moisture and temperature, along with seasonal predictability in soil moisture, was particularly important in predicting community composition and species occurrences. These results indicate that the magnitude and patterns of fluctuations in soil moisture and temperature are important predictors of community composition and plant distribution patterns in alpine plant communities. More broadly, these results highlight that components of temporal change provide important niche axes that can partition species with different growth and life history strategies along environmental gradients in heterogeneous landscapes.
Gastrointestinal morphology is an effective functional dietary proxy that predicts small mammal community structure
Authors: Chapman Olivia S. , McLean Bryan S.
Published: October 2024

The availability and quality of food resources can alter the intensity of competition and predation pressure within communities. Understanding species capacity to respond to global change‐driven shifts in resource distribution is therefore crucial for biodiversity conservation. Small mammal communities are often structured by competition for food resources, but understanding and monitoring these processes are currently hindered by lack of functional dietary trait information in these hard‐to‐sample systems. In this study, we collected a comprehensive suite of gastrointestinal (GI) measurements from 26 small mammal species (including some never reported), compared them with more traditional craniodental traits in predicting dietary guild, and used them in a novel way to understand how diet structures 22 small mammal communities across the Appalachian Mountains of eastern North America. As predicted, we found GI traits to be effective dietary trait proxies; they were equally or more accurate than craniodental proportions in predicting the dietary guild of individual species. Furthermore, at the community level, we found that both the mean and functional dispersion of GI length were positively correlated with latitude and measures of temperature seasonality. Our results indicate that small mammal communities in more seasonal environments are filtered to include species with longer GI tracts (on average) as well as those that can partition food resources more finely, as expected based on the lower productivity of these regions. Conversely, communities in less seasonal environments display functional redundancy from the addition of species with short to intermediate GI lengths. Proportions of the GI tract represent novel dietary traits that can illuminate community assembly processes across regional environmental gradients and in the face of changing timing and availability of resources.
Current Trends in Biophysical Modeling of eDNA Dynamics for the Detection of Marine Species
Authors: Pastor Rollan Ane , Sherman Craig D. H. , Ellis Morgan R. , Tuohey Kate , Vennell Ross , Foster‐Thorpe Cian , Treml Eric A.
Published: October 2024

Marine pest introductions continue to occur and increase at accelerated rates, threatening the marine environment and blue economy. Environmental DNA (eDNA) is a tool for determining the presence of both indigenous and nonindigenous species, via the detection of genetic material that is shed into the local environment. Although eDNA approaches have gained widespread adoption in the last decade, fundamental knowledge gaps remain around factors that can influence the probability of detection, and how to optimize eDNA sampling in aquatic environments. Here, we partition eDNA research into four major research themes: eDNA concentration (shedding and decay), transport (advection and mixing), sampling design strategies, and the modeling of these dynamics. We review current developments and challenges in each theme with a focus on field sampling strategies and the use of biophysical models for understanding the movement of modeling eDNA in complex aquatic environments. We then introduce three modeling case studies from a large embayment where we (1) quantify the spatial and temporal variability of eDNA dispersion, (2) use biophysical models to inform a field sampling strategy, and (3) demonstrate a backtracking modeling technique to identify upstream DNA sources to an existing sample (monitoring) site. We conclude by identifying specific recommendations to help improve future eDNA studies. This work highlights how biophysical models can be applied to improve early detection and informing response and management decisions.