bluuebunny/crossref_metadata_2025 huggingface dataset:
IL-10-modulated dendritic cells from birch pollen- and hazelnut-allergic patients facilitate Treg-mediated allergen-specific and cross-reactive tolerance
Authors: Heinl Patricia Vanessa , Graulich Edith , Weigmann Benno , Wangorsch Andrea , Ose Robert , Bellinghausen Iris , Scheurer Stephan , Vieths Stefan , Saloga Joachim , Steinbrink Kerstin
Published: November 2023

Background Approximately 70 % of individuals allergic to birch
pollen (Bet v 1.01 [Bet]) develop a secondary food allergy (e.g.
hazelnut: Cor a 1.04 [Cor]), due to allergen cross-reactivity.
However, standard immunotherapy for type I allergies often does not
improve the food allergy sufficiently. We analyzed the allergen-specific
and cross-reactive suppressive capacity of primary human regulatory T
cells (Treg) induced by autologous IL-10-modulated dendritic cells
(IL-10 DC) in vitro and in vivo. Methods CD4
T cells of patients with birch pollen and associated
hazelnut allergies were differentiated into Bet-specific or non-specific
induced Treg (iTreg). After Bet- or Cor- specific restimulation the
phenotype, proliferation and suppressive capacity of iTreg subsets were
analyzed. iTreg function was further investigated in humanized mouse
models of airway and intestinal allergy, generated by engraftment of
peripheral blood mononuclear cells from allergic donors into
immunodeficient animals. Results After IL-10 DC priming and
allergen-specific restimulation (Bet or Cor) non-specific control iTreg
remained anergic, whereas Bet-specific iTreg proliferated extensively
and exhibited a regulatory phenotype (enhanced expression of CTLA-4,
PD-1, TNFR2, IL-10). Accordingly, activated Bet-specific iTreg displayed
a high capacity to suppress Bet- and Cor-induced responder T
2 cell responses in vitro, indicating induction
of both allergen-specific (birch) and cross-reactive tolerance
(hazelnut). In vivo, the beneficial effect of Bet-specific iTreg
was verified in humanized mouse models of allergic airway and intestinal
inflammation, resulting in reduced allergen-induced clinical symptoms
and immune responses. Conclusion Human IL-10 DC-induced iTreg
facilitate allergen-specific and cross-reactive tolerance. Therefore,
they are potential candidates for regulatory cell therapy in allergic
and autoimmune diseases.
The impact of highly effective CFTR modulator therapy on utilization of antibiotics at a single pediatric cystic fibrosis care center
Authors: Elson E. , Duehlmeyer Stephanie , Herigon Joshua C. , Wirtz Ann L. , Burns Alaina , Oermann Christopher M. , Lee Brian Robert
Published: November 2023

Objective: Describe antibiotic utilization pre- and
post-widespread utilization of highly effective CFTR modulator therapy
at a single pediatric CF center. Design: In October 2019, the
United States Food and Drug Administration approved
elexacaftor/tezacaftor/ivacaftor (ETI), a highly effective CFTR
modulator therapy, for people with CF (pwCF). We performed a
single-center, retrospective review of PO and IV antibiotics prescribed
for pulmonary exacerbations (PEx) between 1/1/2017 and 12/31/2022.
Results: Of the 193 pwCF included, 69 (36%) received a course
of IV antibiotics in the pre-ETI period compared to 44 (23%) in the
post-period. Oral antibiotic courses decreased from 174 (90%) to 141
(73%) individuals. The median combined IV and PO treatment courses per
individual decreased from 3 to 2. The percent of individuals treated for
resistant organisms including methicillin-resistant Staphylococcus
aureus (46% to 32%) and Pseudomonas aeruginosa (40% to 28%)
also decreased from the pre- and post-ETI period. Conclusions:
This single center experience indicates a dramatic decrease in PO and IV
antibiotics used to treat PEx among pwCF in the post-ETI period.
Direct Synthesis of Layer-Tunable and Transfer-Free Graphene on Device-Compatible Substrates Using Ion Implantation
Authors: Wang Bingkun , Jiang Jun , Baldwin Kevin , Wu Huijuan , Zheng Li , Gong Mingming , Ju Xuehai , Wang Gang , Ye Caichao , Wang Yongqiang
Published: November 2023

Direct synthesis of layer-tunable and transfer-free graphene on
technologically important substrates is highly valued for various
electronics and device applications. Here, we report a novel synthesis
approach combining ion implantation for a precise graphene layer control
and dual-metal smart Janus substrate for a diffusion-limiting graphene
formation, to directly synthesize layer-tunable graphene on arbitrary
substrates without the post-synthesis layer transfer process. C ion
implantation was performed on Cu-Ni film deposited on a variety of
device-relevant substrates. Upon thermal annealing to promote Cu-Ni
alloying, the pre-implanted C-atoms in the Ni layer are pushed towards
the Ni/substrate interface by the top Cu layer due to the poor
C-solubility in Cu. As a result, the expelled C-atoms precipitate into
graphene structure at the interface facilitated by the Cu-like alloy
catalysis. After removing the alloyed Cu-like surface layer, the
layer-tunable graphene on the desired substrate is directly realized.
ReaxFF was performed to elucidate the graphene formation mechanisms in
this novel synthesis approach. Three ordinary devices using
as-synthesized graphene were fabricated on Si, SiO2, and glass
substrates to demonstrate the graphene quality of our layer-tunable and
transfer-free synthesis approach and the excellent performance
characteristics of these low-cost manufacturing devices: field-effect
transistors, heating devices, and near-infrared photodetectors.
An NTRK1-associated Genes Classification Predicts Prognosis in Pediatric Sarcoma Cases
Authors: Yu Lianyuan , HE Lejian
Published: November 2023

Introduction: NTRK-rearranged spindle cell neoplasm is an
emerging tumor entity. The genetic mechanisms and prognostic
implications of this entity are mainly unknown. The corresponding
targeting therapy strategies have been widely developed.
Method: In this study, we summarized the immunohistochemistry
(IHC) and fluorescence in situ hybridization (FISH) characteristics.
Also, we have explored the genetic mechanisms and prognostic
implications of this entity. Results: We identified two
NTRK1-associated gene sub types by consensus clustering. Besides, we
established an NTRK1-associated gene prognostic model that predicted the
survival of Sarcoma (SARC) based on the TCGA dataset. Two
NTRK1-associated genes are related to the prediction of clinical
outcomes. Discussion/Conclusion: A new classification system of
SARC based on NTRK1-associated gene signatures has been established.
Profiling of urinary steroids by lithium ion adduction-based UPLC-MS/MS
Authors: Takao Toshifumi , Pan Yue , Wang Qiuyi , Chen Mengyao
Published: November 2023

RATIONALE: Urine contains free and conjugated steroids. Total
and free steroids were comprehensively quantified; UPLC-MS/MS based on
Li adduction allowed for detecting thirteen 3-OH-containing steroids,
two of which were detected in human urine for the first time.
METHODS: Free urinary steroids were isolated by solid-phase
extraction (SPE) with 80% acetonitrile. The total steroids were
prepared by enzymatic treatment of urine with a cocktail of sulfatase
and glucronidase, protein precipitation, and separation with the above
SPE. The free and total steroids were separately analyzed by UPLC-MS/MS
with and without introduction of Li solution. The
steroids were quantified by two standard curves created using product
ion transitions derived from MH and [M+Li]
. RESULTS: Two groups of human urine, male
and female urine, were analyzed. The absolute amount of each steroid was
determined based on creatinine levels. The differences between the male
and female groups are clearly attributable to sex steroids. 7-OH P5 and
7-OH DHEA were, for the first time, quantified in the total steroids of
female urine, and the latter was identified in both female and male
urine. CONCLUSIONS: By combining UPLC-MS/MS based on lithium
ion incorporation with conventional UPLC-MS/MS, a total of 29 steroids
were identified in human urine containing two newly found steroids.
Do I Belong on TikTok? Algorithimography and Self-Making
Authors: Cerretani James Francis
Published: November 2023

Building on works in digital anthropology, belonging, and self-making, this article delves into physiological aspects of digital lifeworlds. Through collaborative ethnography the author worked with their sibling and the TikTok Ethnography Collective (TEC) to explore TikTok’s utility as a site of self-discovery and learning. From the processes which unfold during the collaboration, a fledgling methodology of algorithmography emerges and is developed through the article. The use of digital ethnographic methods mediated the relationship between the author and their sibling, opening an exploration into self-making practices on TikTok. Building on recent literature around TikTok and self-making, (Bimo and Bhandari 2022), and through “Tik-Talks'' with the author’s sister which centre on multiple forms of diagnoses with Hypermobile Ehlers-Danlos Syndrome (HEDS), this article examines TikTok’s capacity and shortcomings as a place where one can learn to belong against the grain of neoliberal and capitalist cultures.
Main Characters in Search of an Audience: How Institutions used #LearnOnTikTok to Perform Authenticity
Authors: Smout Jennifer
Published: November 2023

#LearnOnTikTok was a 2020 initiative from the social media company which invited accounts to facilitate audience education during the first wave of the COVID-19 pandemic. As previous digital marketing and storytelling strategies can rarely be successfully transposed from other social media platforms to TikTok, organisations must create (and recreate) their own form of entertaining education. TikTok may become a classroom, but that does not guarantee there will be students. A new form of pedagogy must encompass the technological and cultural specificities of TikTok to reach, and then retain, the desired audience. Drawing from my own professional experience as a social media manager, I will examine how the materiality of TikTok videos shape a performance-based memetic culture, and how this in turn, transforms the pedagogic relationship between the institution and the audience. Using examples from DuoLingo and Planet Money, I will show how engaging in TikTokâ€™s culture in a manner that is read as â€œauthenticâ€ by potential students is fundamental to an institutionâ€™s performance as â€œthe Main Characterâ€, which is essential to their capacity to educate on the social media platform.
From Habbo Hotel to TikTok: Navigating Through Complexities of Online Identity and Struggles of Belonging.
Authors: Fahim Hasina
Published: November 2023

In this reflective piece, I explore my experience with different social media platforms and how they have shaped my identity as a first-generation Afghan immigrant in Finland. Using autoethnographic methods, I draw from personal memories and experiences to examine how each platform has influenced my online identity and aided me in navigating the intricacies of online behaviour. Through this intimate exploration, I question the relationship between algorithmic identity and personal identity, offering a personal perspective on the impact of social media in the lives of individuals with close relationships to online platforms.
Longin’s icon from Sofia
Authors: Vojvodic Dragan , Zivkovic Milos
Published: November 2023

The paper discusses an icon of the enthroned Mother of God with Christ, St.
Nicholas, and St. John the Baptist in the National Archaeological Institute
with Museum - Bulgarian Academy of Sciences (NAIM - BAS) in Sofia. The icon
was previously dated to the fifteenth-sixteenth or fourteenth century. We
propose its attribution to Longin, a renowned Serbian painter from the
second half of the sixteenth century. This attribution is explained by the
striking similarities of the stylistic characteristics and most iconographic
elements of the Sofia icon with those of the painter?s signed works. The
icon must have made its way to Sofia from the southern parts of Kosovo and
Metohija, where it was probably created.
Association between Hidradenitis Suppurativa and Abnormalities in Semen Parameters and Sexual Function: A Pilot Study
Authors: Lotan Paz , Taieb Yossef Haim , Barmatz ‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬ Shira , Fisch-Gilad Shira , Dalal Adam , Barak-Levitt Jen , Stein Anat , Altman Eran , Baniel Jack , Golan Shay , Hodak Emmilia , Diment Alexander , Atar Eli , Shoshany Ohad , Shufaro Yoel , Sherman Shany
Published: November 2023

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting patients of reproductive age. Although HS shares risk factors with male infertility, only 1 epidemiological study has evaluated this association. To further evaluate this potential association, findings on semen and hormonal analysis, testicular ultrasound, and the International Index of Erectile Function (IIEF-15) were compared between 28 men attending a tertiary HS clinic during the period April 2019 to April 2021, and 44 healthy controls, spouses of infertile women undergoing semen evaluation before in vitro fertilization. Patients with HS were divided based on the absence or presence of gluteal and genital lesions. Patients with HS were younger than controls (median 27 vs 34 years, p < 0.0004) and had a higher proportion of smokers (86% vs 33%, p < 0.0001). Semen parameters in patients with gluteal-genital lesions, specifically those with severe scrotal involvement necessitating surgery, were lower than the WHO reference values and significantly lower than in patients without gluteal-genital lesions and controls. Erectile dysfunction was reported by 93% of patients with HS. These findings suggest that spermatogenesis and sexual function may be impaired in young men with HS. Therefore, multidisciplinary management of HS should include their evaluation to identify patients who might benefit from semen cryopreservation and sexual treatment.
An Updated Role of Anastrozole in Male Factor Infertility for Avoidance of Need for Assisted Reproductive Technology (ART): A Short Communication
Authors: KK Kaur
Published: November 2023

Male factor infertility causes infertility in about 50% couples. Aromatase hampering agents, like anastrozole restricts the transformation of testosterone (T) to estradiol (E2), minimize negative hampering on pituitary accessibility, and escalate endogenous Gn generation. Aromatase hampering agents have been offered historically to patients with a T: E2 ratio <10. Anastrozole, a more selective hampering agent in contrast to prior agents, has been illustrated to decrease serum E2 quantities and improvement of semen parameters in men with a low T: E2 ratio . Despite, escalated utilization of anastrozole for the treatment of infertile men with escalated peripheral estrogen, it is uncertain if a broader cohort may benefit also from therapy. For corroborating that Naelitz BD, et al. revealed in a multi institutional retrospective cohort study with regards to infertile men with the objective to evaluate the anticipative factors for World Health Organization -sperm concentration category (WHO-SCC)upgrade in case of male patients receiving anastrozole treatment. Their observations were that anastrozole Initiation was correlated with decreased serum estradiol (E2), escalated serum gonadotropin (Gn) quantities, and clinical improvement of semen paradigms in approximately 50% of infertile men. Baseline generation of sperms and greater T: LH ratios anticipated an upgrade of WHO-SCC. E2 quantities, E2: T ratio, and BMI revealed poor anticipative power in this cohort. Men with pretreatment azoospermia displayed poor response to anastrozole needing other treatment modalities. Non-azoospermic infertile men with a T-LH ratio ≥100 (in addition to a lesser degree those with a ratio <100) might gain advantage from treatment with anastrozole and get counseled regarding the anticipated probability of a clinically significant enhancement in semen paradigm. This might expand the availability of different therapies to couples who present with male factor infertility also aid in a trial of lesser invasive / costly fertility treatments.
Review Article on Prevention and Treatment of Gallstones
Authors: HZ Soe
Published: November 2023

Cholecystitis (inflammation of the gallbladder) is mainly caused by gallbladder stones which are common with prevalence as high as 60 % to 70% in American Indians and 10% to 15% in white adults of developed countries and more prevalent in females. It is caused by high content of cholesterol or bilirubin in bile and gallbladder being unable to empty well. It causes no symptoms sometimes, but severe pain and if left untreated gallbladder perforation occurs leading to peritonitis/sepsis and even death in 5 – 50 % of cases. It can be mainly prevented by maintaining normal bodyweight, eating healthy foods mostly fruits and vegetables and doing regular exercises. Its common treatment for symptomatic cases is by three methods of cholecystectomy (surgical removal of gallbladder) out of which laparoscopic cholecystectomy is a standard and minimally invasive method and most people treated go home same day and soon return to normal activities
Democracia y cultura política en México: la opinión de los jóvenes con base en la ENCUCI, 2020
Authors: Mendieta Ramírez Angélica , Estrada Rodríguez José Luis
Published: November 2023

Esta investigación tiene como objetivo conocer la cultura política y las prácticas ciudadanas de tres grupos etarios: a) 15 a 24 años, b) 25 a 34 años, y c) 45 a 54 años, que fueron seleccionados de la Encuesta Nacional de Cultura Cívica (ENCUCI) realizada en 2020. Para alcanzar esta meta, se diseñó una investigación no experimental, de corte transversal. Los resultados generaron un índice de satisfacción democrática que muestra los siguientes hallazgos: a mayor edad de los jóvenes y adultos participantes, disminuye la satisfacción de los ciudadanos por la democracia y se incrementa la preocupación por los temas prioritarios para el país. Estos datos sirven como base para elaborar propuestas que permitan construir políticas públicas e involucrar más a los jóvenes en los procesos de participación y prácticas cívicas que contribuyan a mejorar la calidad de la democracia en México.
Student visual learning style activities in javanese script writing learning
Authors:   Pendidikan Bahasa dan Sastra Jawa, Universitas Negeri Semarang, Iryani Evi
Published: November 2023

The learning activities undertaken by students are essential to be known as the basis for teachers to determine suitable teaching methods and media according to the characteristics of the students. The implication of this research is that teachers can create effective learning experiences by aligning teaching methods and media with the visual learning preferences of students. The research subjects were eighth-grade students at SMP Darussalam Bergas who have a visual learning style. The data for the research included all activities of students with a visual learning style. Data analysis was conducted using Miles and Huberman's data analysis model, which includes data reduction, data presentation, and drawing conclusions. The data analysis results revealed that the characteristics of visual learning style predominantly dominated the students' learning preferences. The activities of visual learners include the following: they find it easier to comprehend what they see rather than what they hear, pay attention to PowerPoint presentations, are more organized and neat, prefer reading to being read to, are meticulous and detail-oriented, have good spelling skills, tend to doodle without specific meaning, are not easily distracted by noise but may be disrupted if the visual display is unclear, visual learners tend to copy everything written by the teacher on the chalkboard, and they prefer to sit near the front of the classroom to have a clear view. Keywords: learning activities, Javanese script, visual learning style
Aboveground Phenology of Tectona philippinensis Benth. & Hook.f.: Insights into Its Adaptive Mechanisms
Authors: Hernandez Jonathan Ogayon
Published: November 2023

The present study investigated the leaf flushing, leaf shedding, flowering, and fruiting cycles in Tectona philippinensis Benth. & Hook.f., shedding light on its adaptation mechanisms for reproductive success and survival. A plotless inventory of tree individuals was undertaken from pre-determined observation points from January 2022 to February 2023 in Lobo, Batangas. All 430 sampled trees exhibited leaf shedding and leaf flushing, while flowering and fruiting events were observed in only 201 and 133 trees, respectively. Major leaf flushing of trees was observed in mid-October, and they generally shed in summer (peak: March). Trees bloomed in early May and reached its peak in June. Fruiting occurred in the wet season (early July to September). There was a general pattern of leaf shedding, flushing, and varying flowering and fruiting cycles, indicating adaptability to environmental changes. The species also exhibited a significant time lag (7–8 months) between leaf flushing and shedding, potentially serving as adaptive features to promote reproductive success and survival in response to changing environmental conditions. Thus, the aboveground phenology of T. philippinensis may vary depending on environmental conditions. The findings are relevant for developing in-situ conservation strategies for the species.
Keywords: flowering, flushing, Lamiaceae, phenological inventory, Shedding
PENINGKATAN PENGETAHUAN SANTRI PONDOK PESANTREN TENTANG PEMBUATAN PAVING BLOK DENGAN CAMPURAN BAHAN LIMBAH PLASTIK
Authors: Usman Kristianto , Kusumastuti Dyah Indriana , Wahono Endro P , Zakaria Ahmad
Published: November 2023

Pondok pesantren (ponpes) Darul Muttaqin diperuntukkan bagi santri pria dan wanita yang sedang menempuh pendidikan agama Islam pada jenjang tertentu. Ponpes ini terletak di desa Kesumadadi, Bekri, Lampung Tengah. Ponpes ini memiliki beberapa sarana belajar mengajar dan asrama untuk para santri. Permasalahan yang dihadapi oleh ponpes, yang dikelola para ustad lulusan dalam dan luar negeri ini, adalah terbatasnya prasarana penunjang, yaitu paving block di area sarana dan asrama. Oleh karena itu, inisiasi untuk meningkatkan pengetahuan santri dalam pembuatan paving block, diharapkan dapat menjadi solusi yang efektif, produktif, dan ramah lingkungan (environmentally friendly), serta berkelanjutan (sustainability). Kandungan limbah plastik dalam paving block akan meningkatkan keandalannya dan dapat menjadi alternatif dalam pengurangan jumlah sampah plastik di lingkungan sekitar ponpes. Peningkatan pengetahuan untuk para santri dan ustad di Ponpes Darul Muttaqin, dilakukan melalui penjelasan teori dan praktek langsung (konsep learning by doing) di lapangan yang meliputi: 1) pengenalan campuran material (job mix), yang terdiri dari campuran pasir, semen, dan limbah plastik dengan perbandingan tertentu, serta target kuat tekan tertentu, misal K-175 (kuat tekan=175 kg/cm2). 2)pengenalan berbagai bentuk cetakan (moulding) paving block. 3)praktek pencampuran material. 4)praktek pencetakan paving block. 5)praktek pengeringan diiringi penyiraman untuk menjaga kadar air optimal paving block (curing process), hal ini dilakukan untuk mencegah susut berlebih (excessive shrinkage) yang dapat menyebabkan retak dan mutu di bawah standar.
REFORMULASI PENGETAHUAN MASYARAKAT DESA KILUAN NEGERI KABUPATEN TANGGAMUS AKIBAT CORONAVIRUS DISEASE (COVID-19)
Authors: Aida Neli , Darmawan Arif , Hermawan Endri
Published: November 2023

Desa Kiluan Negeri dalam beradaptasi dengan kebiasaan baru (New Normal) dan dalam mempertahankan kelangsungan hidup mereka. Terus berkembangnya situasi dan kondisi terkait Coronavirus Disease 2019 (COVID-19) memaksa Pemerintah Daerah untuk mengeluarkan kebijakan yang mengharuskan masyarakat berada dan bekerja dirumah (Work From Home / WFH). Hal ini tentunya jelas mengaharuskan masyarakat untuk beradaptasi serta mencari alternatif atau Mereformulasi penghasilan dalam berjalannya cash flow perekonomian dalam pemenuhan kebutuhan masyarakat desa Kiluan Nageri Kabupaten Tanggamus. Tujuan pengabdian ini adalah terwujudnya Value Added produk olahan hasil tangakapan nelayan menjadi olahan ikan asap yang tahan lama dan bernilai jual yang tinggi untuk pemenuhan kehidupan masyarakat, serta terbukanya pengetahuan masyarakat dalam menghadapi permasalahan kepasrahan dan kebimbangan berusaha pariwisata dan nelayan melalui peningkatan kemampuan masyarakat dalam memanfaatkan inovasi. Hal ini ditunjukkan dengan meningkatnya fasilitas wisata yang mengikuti protokol kesehatan serta pengolahan hasil tangkapan ikan yang tahan lama dan memiliki nilai tambah. Karenanya, metode yang digunakan dalam menjawab masalah tersebut adalah metode Two in One, terutama tentang penguatan kemampuan masyarakat dan sinergitas.  Integrasi penanganan penyediaan protokol kesehatan dan pengasapan ikan  dalam  iringan pendampingan dari UNILA diharapkan bisa memberi nuansa baru yang menyenangkan dalam kegiatan pemberdayaan masyarakat, khususnya di desa Kiluan Negeri Kabupaten Tanggamus.
Pelatihan Pengolahan Minyak Goreng Bekas (Minyak Jelantah) Menjadi Sabun Padat Bagi UMKM dan IRT di Desa Sidosari, Kecamatan Natar, Kabupaten Lampung Selatan
Authors: Ginting Simparmin , Hanif Muhammad , Damayanti Sri , Hermida Lilis
Published: November 2023

This community service aims to help the UMKM engaged in the food industry in Sidosari Village, Natar District, South Lampung Regency (partners). Partners never replace used cooking oil (waste cooking oil) with new ones, but only add new oil to used cooking oil for frying the next food. Partners consider that using used cooking oil from branded cooking oil will be safe to use many times, thereby saving on expenses without knowing the consequences. This understanding is due to the partner's low level of awareness. Therefore, the community service (PkM) is very appropriate for understanding partners about the dangers of waste cooking when used repeatedly without ever being replaced with a new one. The methods used in this service include: socialization, training, and direct practice of processing and making eco-friendly handmade solid laundry soap from used cooking oil. Socialization has been explained the dangers of using cooking oil for health and the environment. Training and practice were provided to partners on how to process and make eco-friendly handmade solid laundry soap made from used cooking oil and bath soap from new oil for household use and even for sale. After participating in this service, residents and the UMKM in particular no longer used cooking oil repeatedly to fry their products to increase product quality. They are enthusiastic to continuously make solid soap from used cooking oil for washing purposes and even make it from new oil for bath soap purposes. Thus, it will save the cost of shopping for laundry soap and bath soap reduce dependence on manufacturer's soap so that the environment is not polluted by detergent waste. It can even be an additional income for those who are serious about getting into the business of making this laundry soap and environmentally friendly homemade bath soap.
SOSIALISASI DAN PENYEDIAAN INSTALASI CUCI TANGAN HIGENIS DI SEKOLAH DASAR
Authors: Werena Rosalia Dwi , Widyawati Ratna
Published: November 2023

Indonesia saat ini tengah menghadapi masa pandemi COVID-19, termasuk Provinsi Lampung. Berdasarkan data Dinas Kesehatan Provinsi Lampung, hingga bulan Maret 2021 terdapat 12.385 kasus suspek COVID-19 dan lebih dari 630 orang diantaranya meninggal dunia. Protokol yang diterbitkan oleh Kementrian Kesehatan  berisi tentang panduan hidup di masa pandemi COVID-19 diantaranya jaga jarak, penggunaan masker, cuci tangan, dll. Dalam praktek di masyarakat khususnya di lingkungan pendidikan dasar (SD), penerapan protokol pencegahan COVID-19 mengalami beberapa permasalahan, khususnya terkait fasilitas cuci tangan. Pemahaman dan pelaksanaan kebiasaan cuci tangan di tingkat SD penting untuk ditingkatkan. Pada beberapa SD, fasilitas cuci tangan kurang memperhatikan faktor higienis. Fasilitas cuci tangan yang tersedia saat ini mengharuskan pemakai   untuk menyentuh keran air secara bergantian, sehingga keran air tersebut berpeluang dalam penyebarluasan COVID-19. Berdasarkan permasalahan tersebut, dibutuhkan desain fasilitas cuci tangan yang mampu menghindarkan pemakai untuk menyentuh secara langsung dan bergantian. Fasilitas cuci tangan yang dikembangkan dalam PkM ini memindahkan operasional keran air dan sabun cair menggunakan kaki, sehingga fasilitas cuci tangan lebih higienis. Pada usulan PkM ini, Program Studi Teknik Kimia Unila merencanakan sosialisasi dan penyediaan 2 Buah unit instalasi cuci tangan higienis yang akan  diberikan  kepada  UPT SD Negeri  2 Sukoharjo I, Pringsewu. Dengan pelaksanaan PkM ini diharapkan kualitas pelaksanaan protokol COVID-19 di tingkat pendidikan dasar Kota Bandarlampung dapat meningkat.
IMPLEMENTASI PERSONAL HYGIENE TERHADAP PENINGKATAN KUALITAS HIDUP BERSIH DI PONDOK PESANTREN NIDHOMUDDIN, DESA NEGARA RATU NATAR, LAMPUNG SELATAN
Authors: Anwar Hasrul , Ulya M. Ridho , Mayasari Rizka , Dzakwan Akhmad
Published: November 2023

Personal hygiene adalah cara perawatan diri manusia untuk memelihara kesehatan mereka secara fisik dan psikis. Pemenuhan personal hygiene diperlukan untuk kenyamaan, keamanan, dan kesehatan individu dan lingkungan. Pondok Pesantren Nidhomuddin, Desa Negara Ratu Natar, Lampung Selatan membina kurang lebih 140 santri yang terdiri dari 60 santri pria dan 80 santri perempuan. Terdapat fasilitas pondok pesantren seperti 1 mesjid, 7 kelas masing- masing untuk santri laki-laki dan perempuan, 10 kamar mandi santri laki-laki dan 18 kamar mandi santri perempuan. Berdasarkan permasalahan di atas, kegiatan ini dilakukan untuk memberikan solusi terhadap permasalahan yang dihadapi warga santri di lingkungan Pondok Pesantren Nidomuddin. Kegiatan pengabdian ini di lakukan di Pondok Pesantren Nidhomuddin, Desa Negara Ratu Natar, Lampung Selatan. langkah-langkah kegiatan pengabdian yang dilakukan yaitu studi pendahuluan dan survey lokasi, memetakan permasalahan terkait personal hygiene, kegiatan  dan pendampingan materi mengenai personal hygiene. Materi yang disampaikan dalam kegiatan worshop yaitu terkait apa itu personal hygiene dan sanitasi lingkungan, tujuan personal hygiene, jenis-jenis personal hygiene, dan implementasi dari  personal hygiene, dan terakhir adalah memberikan kuesioner di awal dan akhir kegiatan workshop untuk mengevaluasi kegiatan pengabdian. Berdasarkan hasil kuesioner yang diberikan kepada para peserta sosialisasi, terjadi peningkatan pengetahuan para santri mengenai personal hygiene dan sanitasi lingkungan. Diharapkan penerapan personal hygiene para santri di Pondok Pesantren Nidhomuddin dapat meningkatkan pemahaman dan kesadaran para santri dalam menerapkan personal hygiene di lingkungan pondok pesantren.

 

Kata kunci:, Pengabdian, personal hygiene, sanitasi, lingkungan
Penguatan Kapasitas Badan Permusyawaratan Desa (BPD) Di Kecamatan Kalianda Kabupaten Lampung Selatan
Authors: Marta Andrimarta , Priangga Piping Setia , Dwijono Aman Toto
Published: November 2023

Secara umum dapat dilihat bahwa peran BPD dalam ketiga fungsi yang ada pada UU No 6 Tahun 2014 Tentang Desa tidak berjalan dengan optimal. Pada prosesnya fungsi BPD sebagai pihak yang ikut membahas dan menyepakati rancangan Peraturan Desa (Perdes), BPD tidak proaktif dibandingkan dengan kepala desa. Rancangan Peraturan desa lebih banyak di ajukan oleh kepala desa dan BPD tidak pernah di ajak membahas rancangan peraturan desa tersebut hanya BPD diminta langsung persetujuan kepala desa dalam hal rancangan peraturan desa tersebut, meskipun rancangan peraturan desa tersebut bisa saja dari BPD tetapi rancangan peraturan desa lebih banyak datang dari pihak kepala desa. Kondisi ini mengakibatkan desa kurang produktif dalam membuat peraturan desa selain peraturan desa yang rutin dibuat selama ini yaitu tentang Perdes tentang Rencana Pembangunan Jangka Menengah Desa (RPJM Desa), Anggaran Pendapatan dan Belanja Desa (APB Desa), dan Rencana Kerja Pemerintah Desa (RKP Desa). Berkaitan dengan penguatan kapasitas perangkat BPD salah satunya dapat ditempuh melalui pemberian pelatihan kepada perangkat BPD. Pelatihan (training) merupakan salah satu alternatif untuk pengembangan sumber daya aparatur desa sangat perlu dilaksanakan secara intensif dan segera dilakukan sebagai konsekuensi perubahan kelembagaan Pemerintah Desa dalam rangkan penguatan kapasitas perangkat desa terutama BPD yang tentunya bermuara pada pemenuhan harapan masyarakat terhadap pelayanan yang memuaskan. Kondisi objektif lainnya yang menjadi pertimbangan penting pelaksanaan pengabdian pada masyarakat ini adalah sebagian besar ketua BPD dan anggota BPD di Kabupaten Lampung Selatan, Kecamatan Kalianda merupakan ketua BPD yang baru terpilih dan menjabat. Sehingga secara nyata membutuhkan pembinaan dalam hal bagaimana praktek penyelenggaraan pemerintahan desa yang lebih baik dan berkualitas. Kegiatan PKM ini telah meningkatkan pengetahuan anggota BPD tentang peraturan dan fungsi kedudukan desa selain itu dalam PKM ini anggota BPD sudah memiliki pengetahuan dan pemahaman tentang pembuatan peraturan desa hingga proses pengawasan kepala desa dan jajarannya dalam menjalankan fungsi pemerintahan yang

ada di desa. Dari hasil evaluasi diketahui bahwa sebelum diadakan PKM ini pengetahuan anggota BPD beserta jajaran berkisar 30% dan meningkat menjadi 80% pemahaman dari tugas dan fungsi BPD tersebut. Kegiatan PKM ini merupakan wujud nyata dari Unila dalam menguatkan fungsi BPD dalam proses penyelenggaraan pemerintahan yang ada di desa.
Facial composition of the deposits of the productive strata based on qualitative interpretation of the log data
Authors: Kerimova K.A. , Samadzadeh A.A.
Published: November 2023

As is known, most of the discovered oil and gas fields in Azerbaijan are associated with terrigenous deposits; thus, the successful discovery of new fields largely depends on determining the genesis of terrigenous formations.

Determining the genesis of reservoir deposits allows apetroleum geologist to more accurately predict the reservoir’sshape and change its main parameters in both lateral and vertical directions.This information also allows us to choose a rational drilling operationsystem in the field. Comprehension of the genesis of the productive stratum deposits is also important in developing oil and gas fields.

The research of the genesis of deposits of productive series is of great interest given the acceleration of exploration and evaluation of their oil and gas potential. In this regard, using the ««qualitative logging facies models» proposed by V.S. Muromtsev in the article, the sections of the wells of the Garbi Absheron, Shimali Absheron, Khazri, and Arzu structures of the North Absheron zone of the uplift PS suites «Fasila», «Upper Kirmaky Clayey» (UKC) and on the sedimentary rocks of the «Upper Kirmaky Sandy» (UKS) formation, a lithofacial analysis of sedimentary rocks was carried out, the genesis of sedimentary rocks was established, and an explanation of the results obtained was given.

Geophysical logging data of the borehole potential curve of intrinsic polarisation were used to build spatial models and 3D models. The constructed models allow us to attribute various shapes of the well potential curve (WP) to deposits of a defined facies composition.

In the research work, the total thickness of facies for the UKC and UKS suites was calculated, three-dimensional spatial models were built considering the variation in their thickness by structuresof the North Absheron zone of the uplift, and 3D models were built by the structures located on them.The facies composition of the sediments of the layers in the «Fasila», «UKC» and «UKS» formations was determined based on created models selected by their appearance and forms of display from WP diagrams of well sections in the Garbi Absheron, Shimali Absheron, Khazri, and Arzu structures.

These models are major for accurately calculating oil and gas reserves in the area, for drilling and designing new wells, and refining the operation scheme.
Ophiolite complex of Piedmont-Ligurian basin (Northern Apennines)
Authors: Yegorova T. , Murovskaya A.
Published: November 2023

The Northern Apennines contain remnants of the Piedmont-Ligurian Basin (PLB) or ocean, which during the Late Mesozoic time (mainly in the Jurassic) separated the paleo-Europe (Iberian plate) from the southern paleocontinent Adria at the Africa promontory. The closure of the PLB and subsequent collision of Europe/Adria in Cretaceous-Cenozoic time led to the exhumation of the ophiolite complex of Northern Apennines in the Ligurian units. The paper gives information obtained by the authors during several field trips on the composition of the ophiolite complex of the Northern Apennines, representative of the composition and structure of the oceanic lithosphere. The latter, absent in the territory of Ukraine, is a key question to understanding the evolution of the oceanic crust, subduction processes, and formation of accretion wedges in the transitional zones to the continents. The Ligurian ophiolites of the PLB constitute an accessible and unique window to track the opening and evolution of the slow-spreading oceanic lithosphere. The Internal Ligurian ophiolites consist of km-scale gabbroic bodies intruded into depleted mantle peridotites and bear remarkable structural and compositional similarities to oceanic lithosphere from slow and ultra-slow spreading ridges. The External Ligurian ophiolites, associated with continental crust material and transition zone between the oceanic and continental crust, include mantle sequences retaining a subcontinental lithospheric origin. The gabbro-peridotite associations from the Internal Ligurian ophiolites were explored in the Bracco-Levanto ophiolite massif, which includes a km-scale gabbroic body, recalling the oceanic core complexes from modern spreading centres, intruded into the mantle peridotites. The peridotites and the gabbros from these ophiolites record a composite history involving deformation and alteration from high temperature to seafloor conditions. The top of the peridotites is covered by tectono-hydrothermal breccias (ophicalcites), radiolarites, and sedimentary breccias that testify to the exposure of peridotites at the seafloor. This succession is then covered by basalts pillow-lavas. Thus, the almost full section of the ophiolite complex is represented here.
IS SILENCE GOLDEN? CONVERSATIONS OF NATIVE SPEAKERS OF RIMI IN SINGIDA- TANZANIA
Authors: Choyo Musa Ibrahim
Published: November 2023

This paper provides an empirical examination of the perception of silence as a communicative act in a Rimi cultural context. Four casual conversations with Rimi native speakers were examined.  Silence in conversation was determined using a turn-taking framework in Conversation Analysis previously described by Sacks et al. (1974) as a turn-taking organization.  Native speakers of Rimi like people in other cultures have beliefs and myths regarding silence. However, these cultural artifacts are often hardly reflected in their real conversation practice. Rimi's belief regarding the value of silence dictates avoidance of silence because they consider it a danger and veiled bad intentions. Despite this cultural orientation regarding silence, in some contexts, Rimi native speakers give it a positive value. The findings show that silence can be used for terminating a topic, showing agreement, and indicating emotions such as sadness. Silence therefore can lead to either harmonious or troubled conversation at the same time. Many prolific studies have shown that Eastern cultures appreciate silence while the Western cultures silence is attributed to incompetence and lack of willingness to participate in communication. This cultural dichotomy regarding the perception of silence between Western and Eastern cultures gives an impression that cultures can either perceive silence positively or negatively. Data from this study show that this understanding is faulty. The data indicate that silence cannot be described categorically as solely positively or negatively perceived in a particular culture; instead, it should be viewed as a variable entity within a single cultural group.
Definition of the crime against the security of humanity (genocide) in international criminal law and the obligation to punish it
Authors: Zamryha A.
Published: November 2023

The relevance of this research topic in today's conditions is of great interest and lies in the fact that genocide is one of the most serious crimes against humanity, and although responsibility for it is officially established, this does not prevent new manifestations of genocide.

In this scientific article, the author made another attempt to consider the theoretical basis of the emergence of the term "genocide" in international law. It is noted that despite the rather long existence of genocide in the world, it was only after the Second World War that genocide was qualified as the most serious crime against humanity. It was analyzed that despite the fact that the UN Convention on the Prevention and Punishment of the Crime of Genocide was signed, its adopted norms could not prevent a new manifestation of this crime. The article gives known historical examples of terrible genocides. It was determined that responsibility for genocide is stipulated by the UN Convention of 1948 "On the Prevention of the Crime of Genocide and its Punishment", which formulates the composition of the crime and its forms. It was also found that the Convention does not directly refer to the responsibility of states, but only indirectly.

The concept of international criminal respon­sibility of the state for genocide is revealed and conclusions are drawn that this concept is controversial.

The judicial practice of the states regarding prosecution for the crime of genocide in accordance with the UN Convention on the Prevention and Punishment of the Crime of Genocide has been analyzed. Conclusions were made about the application by national courts of the Genocide Convention itself, or the national legislation, which contained the definition of the crime of genocide in accordance with the Convention.

The article also reveals current events, namely that the crimes committed by the Russians during the full-scale aggression fall under the articles of the 1948 Genocide Convention, and Ukraine is working to bring Russian criminals to justice for the genocide of the Ukrainian people.

It was concluded that the crimes of the Russians in Ukraine are genocide by all indications and that Russia should bear responsibility for the genocide of the Ukrainian people.
Outer Space Public Law: the 1958-1963 period. Part 2
Authors: Marinich V.K. , Myklush M.I. , Yara O.S.
Published: November 2023

This is the fourth article in the study related to analyzing the process of regulation of space activities.

Considering the results of previous studies of documents adopted by the international community during the 1958-1963 period in the regulation of space activities, this article continues the presentation of the study of the process of Outer Space Public Law development.

The article describes the initiatives of the international community (including the UN General Assembly) connected with the regulation of relations among States in matters of the use of outer space and celestial bodies.

First of all, it describes the process of gradual formation of one of the most important international principles of Public Space Law, which can be attributed to the group of General Principles of Space Activities, namely, "The Principle of a Useful Cosmos”. Also, legal conflicts and difficulties that arose at the initial stage of the formation of this principle as well as the consequences to which they could lead are described.

In addition, the article describes the process of formation of another very important principle of Public Space Law that can also be included in the group of General Principles of Space Activity, namely, "The Principle of Space Traffic”, which at that time already consisted of three special principles formed under the influence of specific international initiatives. Thus, the initiative to streamline space vehicle launches into outer space formed "The Principle of launch registration”. The initiative to organize interaction among States regarding astronauts and space vehicles launched into space formed "The Principle of mutual assistance” In turn, the initiative to organize the safety of space activities formed "the Principle of Responsibility”.

At the same time, all these principles were developed only in the form of Conventionalis stipulatio, which were mainly set out in the Resolutions and Declarations of the UN General Assembly.

Considering the above, it is necessary to pay attention again to the fact that the researcher should not expect from the "Outer Space Law” the form in which this "Law” is accustomed to consider, due to the exclusivity of the environment to which this new "Law” was formed.
Development of cooperation in the space industry: from 1959 to 1962
Authors: Pіddubnyі O. , Pushkar M. , Golovko L.
Published: November 2023

The article reveals the main aspects of the or­ganization of cooperation in space activities at the initial stage of its development when the fiercest space race between the Union of Soviet Socialist Republics and the United States of America was taking place. The main goals of the international community concerning joint research and develop­ment of outer space and celestial bodies, as well as the circumstances that influenced the formation of such cooperation at this stage, are explained and analyzed.

In addition, the article is also concerned with the issue of the international bodies establishment related to the organization and control of joint space activity, the issue of the organization of in­terstate cooperation in outer space in the direction of creating communication accessible to the pop­ulation of the entire planet with the help of satel­lites, the issue of legal regulation of joint activity in outer space and on celestial bodies, as well as the issue of creating an international network of space­ports for launching sounding rockets by all interest­ed participants in space activities (in particular, to make it possible for non-state organizations to take part in space activities).

Considering the modern competition among states in the struggle for dominance in outer space and on celestial bodies and the dangers that such a competition brings, the study returns to the origins of space activity to identify and analyze the factors that influenced the formation of international cooperation in space (both negatively and positively).

The main focus is on international documents adopted by the United Nations General Assembly between 1959 and 1962.

Specifically, the results of the study of the three main Resolutions adopted by the General Assembly of the United Nations in this period regarding international cooperation in the use of outer space for peaceful purposes are presented.