bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone Turnover Markers Changes Induced by Plateletpheresis May Be Minimized with Oral Supplementation of Calcium, Minerals, and Vitamin D before the Procedures: A Non-Randomized, Controlled Study
Authors: Barrientos-Galeana Edgar , Tolentino-Dolores Mari Cruz , Morales-Hernández Rosa María , Sámano Reyna , Chico-Barba Gabriela , Fernández-Sánchez Emmanuel , Zamora-Sánchez Lizbeth Jazmín , Alonso-López Alma Delia , López-Martínez Heriberto , Alba-Rosales Tania , Sánchez-Guerrero Sergio Arturo
Published: December 2022

Apheresis allows the collection of specific blood components but changes serum calcium (Ca), magnesium (Mg), copper (Cu), zinc (Zn), and hormones involved in bone metabolism due to citrate infusion. We assessed the effect of oral supplementation of calcium, vitamin D, and minerals as pills or an enriched diet before plateletpheresis donation on levels of divalent cations, hormones, and bone turnover markers that may prevent metabolic changes. Methods: Non-randomized controlled study including 134 donors. Serum parathyroid hormone (PTH), Ca, Mg, Zn, Cu, osteocalcin (OC), vitamin D, and type-1 collagen C-terminal telopeptide (CTX-1) levels were measured at baseline and post-procedure. Donors were divided into four groups: supplemented with calcium carbonate and vitamin D (cal + vitd); those receiving calcium, minerals, and vitamin D (cal + vitd + min); those receiving a calcium-rich diet (diet) and a control group (control). Results: PTH levels increased >1-fold, whereas tCa, tMg, Zn, Cu, iCa, iMg, and vitamin D levels decreased immediately after apheresis amongst donors of any group; when these levels were measured two weeks later, donors in the calcium-vitd and cal + vitd + min groups returned to basal values; donors in the cal + vitd + min group were the only group that kept their levels of OC and CTX unchanged at the different study times. Conclusions: Bone turnover markers changes induced by plateletpheresis may be minimized with oral supplementation of calcium, minerals, and vitamin D two days before the procedures.
Device Selection for Transcatheter Aortic Valve Implantation
Authors: Granger Camille , Guedeney Paul
Published: December 2022

Twenty years after the first implantation by Alain Cribier and his team, transcatheter aortic valve implantation (TAVI) has demonstrated its efficacy and safety in patients with symptomatic severe aortic stenosis with high, intermediate, and even low surgical risk [...]
Post-Acute Sequelae of COVID-19: The Potential Role of Exercise Therapy in Treating Patients and Athletes Returning to Play
Authors: Cavigli Luna , Fusi Chiara , Focardi Marta , Mandoli Giulia Elena , Pastore Maria Concetta , Cameli Matteo , Valente Serafina , Zorzi Alessandro , Bonifazi Marco , D’Andrea Antonello , D’Ascenzi Flavio
Published: December 2022

Post-acute sequelae of coronavirus disease 19 (COVID-19) (PASC) describe a wide range of symptoms and signs involving multiple organ systems occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, representing a growing health problem also in the world of sport and the athletic population. Patients with PASC have new, returning, or persisting symptoms four or more weeks after the infection. Among the most frequent symptoms, patients complain of fatigue, dyspnea, exercise intolerance, and reduced functional capacity that interfere with everyday life activity. The role of exercise programs in PASC patients will be identified, and upcoming studies will establish the magnitude of their benefits. However, the benefits of exercise to counteract these symptoms are well known, and an improvement in cardiopulmonary fitness, functional status, deconditioning, and quality of life can be obtained in these patients, as demonstrated in similar settings. Based on this background, this review aims to summarise the current evidence about the PASC syndrome and the benefit of exercise in these patients and to provide a practical guide for the exercise prescription in PASC patients to help them to resume their functional status, exercise tolerance, prior activity levels, and quality of life, also considering the athletic population and their return to play and sports competitions.
Prevalence of Herpesvirus DNA in Corneal Transplant Recipients
Authors: Bu Julia Bing , Grabitz Stephanie D. , Pfeiffer Norbert , Wasielica-Poslednik Joanna
Published: December 2022

Purpose: Graft failure after penetrating keratoplasty (PK) is a serious complication, especially in eyes with herpetic keratitis (HK). This study evaluated the prevalence and graft survival of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in recipient corneas during PK. Methods: The retrospective study was performed at the Department of Ophthalmology at University Hospital in Mainz, Germany. We analyzed data from every patient who underwent PK between January 2020 and June 2021. According to our clinical routine, we performed HSV-1 and VZV polymerase chain reaction (PCR) on all excised corneal buttons regardless of the primary clinical diagnosis. Results: We included 112 eyes of 112 consecutive patients who underwent PK. At the time of PK, 91 (81.25%) patients had no history of HK and 21 (18.75%) patients did. The recipient corneas of 91 patients without a history of HK tested positive for HSV-1 DNA in 12 (13.2%) eyes, for VZV DNA in 3 (3.3%) eyes, and for HSV-1 and VZV DNA simultaneously in 2 (2.2%) eyes. The recipient corneas of 21 patients with a preoperative history of HK tested positive for HSV-1 DNA in 13 (61.9%) eyes and VZV DNA in 1 (4.8%) eye. All patients with positive herpes DNA and no history of HK prior to PK received antiherpetic treatment and had a 100% graft survival rate after 1 year. Conclusions: We found herpesvirus DNA in 18.7% of recipient corneas without clinical suspicion or history of herpes keratitis. This suggests the need of routine HSV-1 and VZV PCR testing in all explanted corneas regardless of clinical suspicion, to detect, treat and prevent possible recurrence of herpes infection in corneal grafts and support graft survival.
Improvement in Glucocorticoid-Induced Osteoporosis on Switching from Bisphosphonates to Once-Weekly Teriparatide: A Randomized Open-Label Trial
Authors: Nanki Toshihiro , Kawazoe Mai , Uno Kiyoko , Hirose Wataru , Dobashi Hiroaki , Kataoka Hiroshi , Mimura Toshihide , Hagino Hiroshi , Kono Hajime
Published: December 2022

This randomized, open-label, multicenter, parallel study imitating real-world clinical practice assessed the effect of switching to weekly teriparatide in patients with glucocorticoid-induced osteoporosis (GIO) with a lumbar spine/proximal femur bone mineral density (BMD) T-score ≤ −2.0 or ≤−1.0 and a fragility fracture. Forty-four patients were randomized. The mean durations of the corticosteroid and bisphosphonate administrations were 90.0 and 51.3 months. The baseline BMD at L1–L4 was 0.828 and 0.826 g/cm2 in Groups B (bisphosphonate) and T (teriparatide); at the femur (total), these values were 0.689 and 0.661 g/cm2. The mean change in BMD was numerically higher with teriparatide vs. bisphosphonate but not statistically significant. The mean percentage changes from baseline in BMD at L1–L4 after a 72-week treatment were 0.5% and 4.1% in Groups B and T. The incidence of new fractures was higher in the patients taking bisphosphonates vs. those receiving once-weekly teriparatide at 72 weeks (18.2% vs. 11.8%) and 144 weeks (22.7% vs. 17.6%). The mean percentage change in femur (trochanter) BMD (0.035 [0.007–0.063]; p = 0.02) was significantly greater with teriparatide vs. bisphosphonates. Adverse events (AEs) were more frequent with teriparatide vs. bisphosphonates. Switching to once-weekly teriparatide tended to increase lumbar spine BMD and reduce the occurrence of new fractures vs. bisphosphonates.
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review
Authors: Hu Yingkun , Huang Jinghuan , Chen Chunying , Wang Yi , Hao Zhuowen , Chen Tianhong , Wang Junwu , Li Jingfeng
Published: December 2022

Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance between bone resorption and bone formation. The regulation of physiological bone remodeling by a complex system that involves multiple cells in the skeleton is closely related to bone homeostasis. Loss of bone mass or repair of bone is always accompanied by changes in bone homeostasis. However, due to the complexity of bone homeostasis, we are currently unable to identify all the mechanisms that affect bone homeostasis. To date, bone macrophages have been considered a third cellular component in addition to osteogenic spectrum cells and osteoclasts. As confirmed by co-culture models or in vivo experiments, polarized or unpolarized macrophages interact with multiple components within the bone to ensure bone homeostasis. Different macrophage phenotypes are prone to resorption and formation of bone differently. This review comprehensively summarizes the mechanisms by which macrophages regulate bone homeostasis and concludes that macrophages can control bone homeostasis from osteoclasts, mesenchymal cells, osteoblasts, osteocytes, and the blood/vasculature system. The elaboration of these mechanisms in this narrative review facilitates the development of macrophage-based strategies for the treatment of bone metabolic diseases and bone defects.
Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope
Authors: Ahmad Mohammad Zaki , Mohammed Abdul Aleem , Algahtani Mohammed S. , Mishra Awanish , Ahmad Javed
Published: December 2022

Psoriasis is a typical dermal condition that has been anticipated since prehistoric times when it was mistakenly implicit in being a variant of leprosy. It is an atypical organ-specific autoimmune disorder, which is triggered by the activation of T-cells and/or B-cells. Until now, the pathophysiology of this disease is not completely explicated and still, many research investigations are ongoing. Different approaches have been investigated to treat this dreadful skin disease using various anti-psoriatic drugs of different modes of action through smart drug-delivery systems. Nevertheless, there is no ideal therapy for a complete cure of psoriasis owing to the dearth of an ideal drug-delivery system for anti-psoriatic drugs. The conventional pharmacotherapy approaches for the treatment of psoriasis demand various classes of anti-psoriatic drugs with optimum benefit/risk ratio and insignificant untoward effects. The advancement in nanoscale drug delivery had a great impact on the establishment of a nanomedicine-based therapy for better management of psoriasis in recent times. Nanodrug carriers are exploited to design and develop nanomedicine-based therapy for psoriasis. It has a promising future in the improvement of the therapeutic efficacy of conventional anti-psoriatic drugs. The present manuscript aims to discuss the pathophysiology, conventional pharmacotherapy, and contemporary research in the area of nanoscale topical drug delivery systems for better management of psoriasis including the significance of targeted pharmacotherapy in psoriasis.
Antibacterial Electrodeposited Copper-Doped Calcium Phosphate Coatings for Dental Implants
Authors: Pierre Camille , Bertrand Ghislaine , Pavy Iltaf , Benhamou Olivier , Rey Christian , Roques Christine , Combes Christèle
Published: December 2022

Dental implants provide a good solution for the replacement of tooth roots. However, the full restoration of tooth functions relies on the bone-healing period before positioning the abutment and the crown on the implant, with the associated risk of post-operative infection. This study aimed at developing a homogeneous and adherent thin calcium phosphate antibacterial coating on titanium dental implants by electrodeposition to favor both implant osseointegration and to limit peri-implantitis. By combining global (XRD, FTIR-ATR, elemental titration) and local (SEM, Raman spectroscopy on the coating surface and thickness) characterization techniques, we determined the effect of electrodeposition time on the characteristics and phases content of the coating and the associated mechanism of its formation. The 1-min-electrodeposited CaP coating (thickness: 2 ± 1 μm) was mainly composed of nano-needles of octacalcium phosphate. We demonstrated its mechanical stability after screwing and unscrewing the dental implant in an artificial jawbone. Then, we showed that we can reach a high copper incorporation rate (up to a 27% Cu/(Cu+Ca) molar ratio) in this CaP coating by using an ionic exchange post-treatment with copper nitrate solution at different concentrations. The biological properties (antibiofilm activity and cytotoxicity) were tested in vitro using a model of mixed bacteria biofilm mimicking peri-implantitis and the EN 10993-5 standard (direct contact), respectively. An efficient copper-doping dose was determined, providing an antibiofilm property to the coating without cytotoxic side effects. By combining the electrodeposition and copper ionic exchange processes, we can develop an antibiofilm calcium phosphate coating on dental implants with a tunable thickness and phases content.
A Fully-Differential CMOS Instrumentation Amplifier for Bioimpedance-Based IoT Medical Devices
Authors: Corbacho Israel , Carrillo Juan M. , Ausín José L. , Domínguez Miguel Á. , Pérez-Aloe Raquel , Duque-Carrillo J. Francisco
Published: December 2022

The implementation of a fully-differential (FD) instrumentation amplifier (IA), based on indirect current feedback (ICF) and aimed to electrical impedance measurements in an Internet of Things (IoT) biomedical scenario, is presented. The IA consists of two FD transconductors, to process the input signal and feed back the output signal, a summing stage, used to add both contributions and generate the correcting current feedback signal, and a common-mode feedback network, which controls the DC level at the output nodes of the circuit. The transconductors are formed by a voltage-to-current conversion resistor and two voltage buffers, which are based on a super source follower cell in order to improve the overall response of the circuit. As a result, a compact single-stage structure, suitable for achieving a high bandwidth and a low power consumption, is obtained. The FD ICF IA has been designed and fabricated in 180 nm CMOS technology to operate with a 1.8-V supply and provide a nominal gain of 4 V/V. Experimental results show a voltage gain of 3.78 ± 0.06 V/V, a BW of 5.83 MHz, a CMRR at DC around 70 dB, a DC current consumption of 266.4 μA and a silicon area occupation of 0.0304 mm2.
Effects of Water Masses and Circulation on the Surface Water Partial Pressure of Carbon Dioxide in Summer in Eastern Beibu Gulf, China
Authors: Ma Yu , Li Tuanjie , Xia Huayong , Li Ruixiang , Cao Yonggang , Shi Huaming , Xu Xin , Zhang Jinshang , Zhang Weijie , Su Xibao
Published: December 2022

A gulf is a typical ecological zone where carbon cycle is jointly affected by complex environmental factors and strong human activities, and the Beibu Gulf has complex water masses and circulation structures. In this study, we used underway, continuous observational data of the surface water partial pressure of carbon dioxide (pCO2), temperature (SST), salinity (SSS), dissolved oxygen (DO), and chlorophyll α along with vertical profile observations of temperature, salinity, carbonate system parameters and nutrients to determine the spatiotemporal variations and research effects of water masses and circulation on summer pCO2 in the eastern part of Beibu Gulf. In the summers of 2011 and 2014, the mean pCO2 in the eastern part of Beibu Gulf was 417 μatm and 405 μatm, respectively, and the mean sea–air CO2 flux was 3.3 mmol m−2 d−1 and 1.6 mmol m−2 d−1, respectively. In the summer of 2011, the northern part of the Beibu Gulf was controlled by a cyclonic circulation, and pCO2 at the center of the cyclonic circulation increased by more than 15 μatm to a mean value of more than 10 μatm above that of the surrounding waters. The southern part of the Beibu Gulf was affected by an anticyclonic circulation and western coastal water masses, with a high temperature, low salinity, low pCO2, and downwelling surface waters. In the summer of 2011, the mean pCO2 was approximately 17 μatm lower than that in the surrounding waters, and no clear downwelling was observed in summer 2014. The eastern part of Beibu Gulf was a source of atmospheric CO2 in the summer, only the region affected by the northern coastal water in the eastern part of Beibu Gulf was a sink of atmospheric CO2, and pCO2 had distinctly different spatiotemporal distributions under the influence of complex water masses and circulation structures.
Optimization of Blade Position on an Asymmetric Pre-Swirl Stator Used in Container Ships
Authors: Jin Woo-Seok , Kim Moon-Chan , Kang Jin-Gu , Shin Yong-Jin , Lee Kyuong-Wan
Published: December 2022

Owing to environmental regulations, ships are equipped with a pre-swirl stator (PSS), which is one of the most effective energy-saving devices (ESDs) that is widely applied to various kinds of ships. It improves energy efficiency by recovering the rotational kinetic energy of the propeller with the aid of a PSS placed in front of the propeller. In this study, an asymmetric PSS system is applied to the 2500 TEU eco-friendly liquefied natural gas (LNG) fuel feeder container ship, aimed at optimizing the position of stator blades, using a potential-based program. Additionally, a parametric study was conducted for evaluating the optimum pitch angle and blade spacing. STAR-CCM+ was used for validating the efficiency of the final design. The Samsung towing tank and large cavitation tunnel were also utilized to verify the improvement in the performance of the proposed PSS. Although the efficiency gain is not largely affected by blade position optimization, the cavitation and pressure fluctuation issues are addressed by improving the in-flow to the propeller. Therefore, blade spacing optimization of the stator is important for container ships whose cavitation performance is very significant, especially the relatively high-speed commercial vessels.
System Reliability of a Semi-Submersible Drilling Rig Considering the Effects of the Main Nodes
Authors: Ye Qian , Jin Wei-liang , Bai Yong
Published: December 2022

In this paper, structural systems reliability analysis was used to estimate the system reliability of a typical semi-submersible based on the characteristic structure failure mechanisms under extreme wave loads. First, a three-dimensional simulation model was created for the chosen semi-submersible platform using an elastic-perfectly plastic material model, neglecting the effect of the strain hardening assumption. Then, under design wave conditions, and characteristic structural failure mechanisms of a semi-submersible platform were examined, and a system reliability model was developed based on the failure mechanism of the chosen platform. Finally, system reliability methods were used to determine the platform’s system reliability. It was discovered that the main node’s system reliability makes a significant contribution to the overall structure reliability, so it is strongly advised that the reliability of the main nodes be taken into account when determining the overall structure’s reliability. This research aims to apply reliability theory in offshore engineering and, ideally, to encourage the reliability-based design of semi-submersible platforms and other similar structures.
Screening of Antibacterial Activity of Some Resupinate Fungi, Reveal Gloeocystidiellum lojanense sp. nov. (Russulales) against E. coli from Ecuador
Authors: Jaramillo-Riofrío Andrea , Decock Cony , Suárez Juan Pablo , Benítez Ángel , Castillo Gabriel , Cruz Darío
Published: December 2022

Bacterial resistance to antibiotics is a serious public health problem that needs new antibacterial compounds for control. Fungi, including resupinated fungi, are a potential source to discover new bioactive compounds efficient again to bacteria resistant to antibiotics. The inhibitory capacity against the bacterial species was statistically evaluated. All the species (basidiomata and strains) were molecularly characterized with the ITS1-5.8S-ITS2 barcoding marker. The strains Ceraceomyces sp., Fuscoporia sp., Gloeocystidiellum sp., Oliveonia sp., Phanerochaete sp., and Xenasmatella sp. correspond to resupinate Basidiomycetes, and only the strain Hypocrea sp. is an Ascomycete, suggesting contamination to the basidiome of Tulasnella sp. According to the antagonistic test, only the Gloeocystidiellum sp. strain had antibacterial activity against the bacterial species Escherichia coli of clinical interest. Statistically, Gloeocystidiellum sp. was significantly (<0.001) active against two E. coli pathotypes (O157:H7 and ATCC 25922). Contrarily, the antibacterial activity of fungi against other pathotypes of E. coli and other strains such as Serratia sp. was not significant. The antibacterial activity between 48 and 72 h increased according to the measurement of the inhibition halos. Because of this antibacterial activity, Gloeocystidiellum sp. was taxonomically studied in deep combined morphological and molecular characterization (ITS1-5.8S-ITS2; partial LSU D1/D2 of nrDNA). A new species Gloeocystidiellum lojanense, a resupinate and corticioid fungus from a tropical montane rainforest of southern Ecuador, with antibacterial potential against E. coli, is proposed to the science.
Phylogenesis of the Functional 1-Aminocyclopropane-1-Carboxylate Oxidase of Fungi and Plants
Authors: Li Yanan , Qi Man , Zhang Qi , Xu Zhixu , Zhang Yan , Gao Yuqian , Qi Yuancheng , Qiu Liyou , Wang Mingdao
Published: December 2022

The 1-aminocyclopropane-1-carboxylic acid (ACC) pathway that synthesizes ethylene is shared in seed plants, fungi and probably other organisms. However, the evolutionary relationship of the key enzyme ACC oxidase (ACO) in the pathway among organisms remains unknown. Herein, we cloned, expressed and characterized five ACOs from the straw mushroom (Volvariella volvacea) and the oyster mushroom (Pleurotus ostreatus): VvACO1-4 and PoACO. The five mushroom ACOs and the previously identified AbACO of the button mushroom contained all three conserved residues that bound to Fe(II) in plant ACOs. They also had variable residues that were conserved and bound to ascorbate and bicarbonate in plant ACOs and harbored only 1–2 of the five conserved ACO motifs in plant ACOs. Particularly, VvACO2 and AbACO had only one ACO motif 2. Additionally, VvACO4 shared 44.23% sequence identity with the cyanobacterium Hapalosiphon putative functional ACO. Phylogenetic analysis showed that the functional ACOs of monocotyledonous and dicotyledonous plants co-occurred in Type I, Type II and Type III, while putative functional gymnosperm ACOs also appeared in Type III. The putative functional bacterial ACO, functional fungi and slime mold ACOs were clustered in ancestral Type IV. These results indicate that ACO motif 2, ACC and Fe(II) are essential for ACO activity. The ACOs of the other organisms may come from the horizontal transfer of fungal ACOs, which were found ordinarily in basidiomycetes. It is mostly the first case for the horizontal gene transfers from fungi to seed plants. The horizontal transfer of ACOs from fungi to plants probably facilitates the fungal-plant symbioses, plant–land colonization and further evolution to form seeds.
Assessing the Efficacy of Anastomosis between Ansa Cervicalis and Facial Nerve for Patients with Concomitant Facial Palsy and Peripheral Neuropathy
Authors: Balaci Georgeta Magdalena , Oṣlobanu Aurel , Major Zoltán Zsigmond , Dávid Réka Emma , Iepure Maria , Hancu Daniela , Popa Adina Mihaela , Florian Ioan Ṣtefan
Published: December 2022

Background: For decades, patients with facial asymmetry have experienced social interaction difficulties, leading them to seek treatment in the hope of restoring facial symmetry and quality of life. Researchers evaluated numerous surgical techniques, but achieving results remains a significant hurdle. Specifically, anastomosis between the ansa cervicalis (AC) and facial nerve (FN) can hinder the patient’s physical appearance. Objective: Our study goal was to examine the efficiency of anastomosis between AC and FN for facial motor function recovery even in the presence of peripheral neuropathy. Materials and Methods: Four patients diagnosed with facial palsy grade VI on the House & Brackmann Scale (HB) after vestibular schwannoma (VS) resection (Koos grade IV) via the retrosigmoid approach underwent AC and FN anastomosis. Outcomes were related to tumor grade, previous therapy, and the time between postoperative facial palsy and anastomosis. Images and neurophysiological data were evaluated. Results: After vs. resection, all four patients demonstrated HB grade VI facial palsy for an average of 17 months. During the follow-up program, lasting between 6 and 36 months, two patients were evaluated as having HB grade III facial palsy; the other two patients were diagnosed with grade IV HB facial palsy. None of the patients developed tongue atrophy, speech disorder, or masticatordys function. Conclusions: Anastomosis between the AC and FN is a safe and effective treatment for facial paralysis after cerebellopontine tumor resection. Nerve reanimation may be feasible even for patients with peripheral polyneuropathy. This study also offers a new option for patients with a progression-free status.
Is Cemented Dual-Mobility Cup a Reliable Option in Primary and Revision Total Hip Arthroplasty: A Systematic Review
Authors: Ciolli Gianluca , Mesnard Guillaume , Deroche Etienne , Gunst Stanislas , Batailler Cécile , Servien Elvire , Lustig Sébastien
Published: December 2022

Background: Instability is a common complication following total hip arthroplasty (THA). The dual mobility cup (DMC) allows a reduction in the dislocation rate. The goal of this systematic review was to clarify the different uses and outcomes according to the indications of the cemented DMC (C-DMC). Methods: A systematic review was performed using the keywords “Cemented Dual Mobility Cup” or “Cemented Tripolar Cup” without a publication year limit. Of the 465 studies identified, only 56 were eligible for the study. Results: The overall number of C-DMC was 3452 in 3426 patients. The mean follow-up was 45.9 months (range 12–98.4). In most of the cases (74.5%) C-DMC was used in a revision setting. In 57.5% DMC was cemented directly into the bone, in 39.6% into an acetabular reinforcement and in 3.2% into a pre-existing cup. The overall dislocation rate was 2.9%. The most frequent postoperative complications were periprosthetic infections (2%); aseptic loosening (1.1%) and mechanical failure (0.5%). The overall revision rate was 4.4%. The average survival rate of C-DMC at the last follow-up was 93.5%. Conclusions: C-DMC represents an effective treatment option to limit the risk of dislocations and complications for both primary and revision surgery. C-DMC has good clinical outcomes and a low complication rate.
Comparison of the Effectiveness of Palonosetron and Ramosetron in Preventing Postoperative Nausea and Vomiting: Updated Systematic Review and Meta-Analysis with Trial Sequential Analysis
Authors: Kim Hyo Jin , Ahn EunJin , Choi Geun Joo , Kang Hyun
Published: December 2022

This updated systematic review and meta-analysis with trial sequential analysis aimed to compare the efficacy of the perioperative administration of palonosetron with that of ramosetron in preventing postoperative nausea and vomiting (PONV). A total of 17 randomized controlled trials comparing the efficacy of the perioperative administration of palonosetron to that of ramosetron for preventing PONV were included. The primary outcomes were the incidences of postoperative nausea (PON), postoperative vomiting (POV), and PONV, which were measured in early, late, and overall phases. Subgroup analysis was performed on the basis of the administration time of the 5-HT3 receptor antagonist and divided into two phases: early phase and the end of surgery. A total of 17 studies with 1823 patients were included in the final analysis. The incidence of retching (relative risk [RR] = 0.525; 95% confidence interval [CI] = 0.390 to 0.707) and late POV (RR = 0.604; 95% CI = 0.404 to 0.903) was significantly lower in the palonosetron group than in the ramosetron group. No significant differences were demonstrated in the incidence of PON, PONV, complete response, use of antiemetics, and adverse effects. Subgroup analysis showed that palonosetron was superior to ramosetron in terms of early PON, late PON, overall POV, and use of rescue antiemetics when they were administered early; in terms of retching, regardless of the timing of administration. Ramosetron was superior to palonosetron in terms of early PON when they were administered late. The prophylactic administration of palonosetron was more effective than that of ramosetron in preventing the development of retching and late POV. In this meta-analysis, no significant differences in PONV prevention between the two drugs were demonstrated. Further studies are required to validate the outcomes of our study.
Robustness of Radiomics in Pre-Surgical Computer Tomography of Non-Small-Cell Lung Cancer
Authors: Belfiore Maria Paola , Sansone Mario , Monti Riccardo , Marrone Stefano , Fusco Roberta , Nardone Valerio , Grassi Roberto , Reginelli Alfonso
Published: December 2022

Background: Radiomic features are increasingly used in CT of NSCLC. However, their robustness with respect to segmentation variability has not yet been demonstrated. The aim of this study was to assess radiomic features agreement across three kinds of segmentation. Methods: We retrospectively included 48 patients suffering from NSCLC who underwent pre-surgery CT. Two expert radiologists in consensus manually delineated three 3D-ROIs on each patient. To assess robustness for each feature, the intra-class correlation coefficient (ICC) across segmentations was evaluated. The ‘sensitivity’ of ICC upon some parameters affecting features computation (such as bin-width for first-order features and pixel-distances for second-order features) was also evaluated. Moreover, an assessment with respect to interpolator and isotropic resolution was also performed. Results: Our results indicate that ‘shape’ features tend to have excellent agreement (ICC > 0.9) across segmentations; moreover, they have approximately zero sensitivity to other parameters. ‘First-order’ features are in general sensitive to parameters variation; however, a few of them showed excellent agreement and low sensitivity (below 0.1) with respect to bin-width and pixel-distance. Similarly, a few second-order features showed excellent agreement and low sensitivity. Conclusions: Our results suggest that a limited number of radiomic features can achieve a high level of reproducibility in CT of NSCLC.
A Novel Pyroptosis-Related Gene Signature for Prediction of Disease-Free Survival in Papillary Thyroid Carcinoma
Authors: Jiang Kecheng , Lin Bei , Zhang Yu , Lu Kaining , Wu Fan , Luo Dingcun
Published: December 2022

Background: The incidence and recurrence rate of papillary thyroid carcinoma (PTC) are high. Thus, it is critical to accurately identify patients at high risk of recurrence. Pyroptosis is a type of programmed cell death closely related to the progression and prognosis of cancer. However, the role of pyroptosis in PTC remains unclear. Methods: Transcriptome data for PTC patients were obtained from The Cancer Genome Atlas database. The expression level of pyroptosis-related genes (PRGs) in PTC and normal tissues was identified. Based on these differentially expressed genes, a risk score model of disease-free survival (DFS) was established using least absolute shrinkage and selection operator Cox regression. In-cluster and quantitative real-time PCR validations were carried out. A nomogram, in combination with clinical factors, was also established. In addition, its relationship with immune characteristics and tumor gene mutations is discussed. Results: A risk score model with four PRGs, including CASP6, CASP9, IL-18, and NOD1, was established. The samples were divided into high- and low-risk clusters, according to the risk score, revealing significant differences in DFS between the two clusters. A nomogram was established combining age, lymph node metastasis and extrathyroidal extension. The area under the curve (AUC) of predicting one-, five-, and 10-year DFS in PTC patients was 0.745, 0.801, and 0.803, respectively. The low-risk cluster showed higher levels of immune infiltration and immune checkpoint gene expression, while the high-risk cluster demonstrated a higher tumor mutation burden. Conclusion: A predictive DFS model was established, based on PRGs, which may aid in identifying patients at high risk of recurrence. The present study helps to better understand the role of pyroptosis in the progression and prognosis of PTC.
Prostate Artery Embolization: Challenges, Tips, Tricks, and Perspectives
Authors: Moulin Benjamin , Di Primio Massimiliano , Vignaux Olivier , Sarrazin Jean Luc , Angelopoulos Georgios , Hakime Antoine
Published: December 2022

Prostatic artery embolization (PAE) consists of blocking the arteries supplying the prostate to treat benign prostate hypertrophia (BPH). Its effectiveness on both urinary symptoms and flowmetric parameters has now been amply demonstrated by around a hundred studies, including several randomized trials. The main advantage of this procedure is the very low rate of urinary and sexual sequelae, including ejaculatory, with an excellent tolerance profile. The arterial anatomy is a key element for the realization of PAE. Its knowledge makes it possible to anticipate obstacles and prevent potential complications related to nontarget embolization. Nontarget embolization can occur with a small intraprostatic shunt or reflux and has no consequences except some local inflammation symptoms that resolve in a couple of days. Nevertheless, some situations with large arterial shunts arising from the prostatic artery must be recognized (accessory rectal, bladder, or pudendal branches), and must imperatively be protected before embolization, at the risk of exposing oneself to otherwise ischemic complications that are more severe, such as bladder necrosis and skin or mucosal necrosis. This article offers a step-by-step review of the various anatomical and technical key points to ensure technical and clinical success, while avoiding the occurrence of adverse events.
Genetic Approaches for the Treatment of Giant Axonal Neuropathy
Authors: Shirakaki Satomi , Roshmi Rohini Roy , Yokota Toshifumi
Published: December 2022

Giant axonal neuropathy (GAN) is a pediatric, hereditary, neurodegenerative disorder that affects both the central and peripheral nervous systems. It is caused by mutations in the GAN gene, which codes for the gigaxonin protein. Gigaxonin plays a role in intermediate filament (IF) turnover hence loss of function of this protein leads to IF aggregates in various types of cells. These aggregates can lead to abnormal cellular function that manifests as a diverse set of symptoms in persons with GAN including nerve degeneration, cognitive issues, skin diseases, vision loss, and muscle weakness. GAN has no cure at this time. Currently, an adeno-associated virus (AAV) 9-mediated gene replacement therapy is being tested in a phase I clinical trial for the treatment of GAN. This review paper aims to provide an overview of giant axonal neuropathy and the current efforts at developing a treatment for this devastating disease.
Effects of Using Barbed Suture in Myomectomy on Adhesion Formation and Adverse Pregnancy Outcome
Authors: Won Seyeon , Choi Su Hyeon , Lee Nara , Shim So Hyun , Kim Mi Kyoung , Kim Mi-La , Jung Yong Wook , Yun Bo Seong , Seong Seok Ju
Published: December 2022

Background: There is still concern regarding postoperative adhesion formation and adverse effects on pregnancy outcomes caused by barbed suture (BS) after myomectomy. The aim of this study was to compare the postoperative adhesion and pregnancy outcomes between conventional suture (CS) and BS after minimally invasive myomectomy (MIM) by robotic myomectomy (RM) or laparoscopic myomectomy (LM). Methods: The medical records of 94 women who had undergone MIM with CS and 97 who had undergone MIM with BS and achieved pregnancy were reviewed. Postoperative adhesion was evaluated following cesarean section. Results: The number of removed myomas was greater (5.3 ± 4.6 vs. 3.5 ± 3.1, p = 0.001) and the size of the largest myoma was larger (7.0 ± 2.2 vs. 5.8 ± 2.7 cm, p = 0.001) in the BS group relative to the CS group. A total of 98.9% of patients in the CS group and 45.4% in the BS group had undergone LM (p < 0.001), while the others underwent RM. There was no significant difference in the presence of postoperative adhesion at cesarean section between the BS and CS groups (45.5 vs. 43.7%, p = 0.095). Additionally, there were no intergroup differences in pregnancy complications such as preterm labor, placenta previa, accrete or abruption. Note also that in our logistic regression analysis, the suture type (BS or CS) was excluded from the independent risk factors regarding postoperative adhesion formation. Conclusions: Our data indicated that the incidence of postoperative adhesion after MIM with BS was similar when compared with CS. Also it seems that the suture type does not have a significant effect on pregnancy outcomes.
How Does the Heterogeneity of Family Structure Affect the Area of Land Transferred Out in the Context of Rural Revitalization?—Experience from CHIP 2013
Authors: Zhang Huaquan , Jin Ruijia , Ankrah Twumasi Martinson , Xiao Shishun , Chandio Abbas Ali , Sargani Ghulam Raza
Published: December 2022

Using the sample data of rural households in China’s income survey (CHIP 2013), this paper divides the family structure into elite and incomplete families and analyzes the impact of family structure’s heterogeneity on land transferred out. The Tobit and Ordinary Least Squares (OLS) models are applied to achieve the study’s objectives. The results show that the elite family has a significant positive impact on the paid land subcontract area, while the incomplete family is not significant. After further refining the elite families, it is found that the influence of the families with the political status of Party members (non-grassroots cadres) on the land transfer area is more significant, while the influence of the families with the status of grassroots cadres on the land transfer area is less significant. Then, the formation mechanism of the difference between these two is discussed, which may be explained by the heterogeneity of their endowment structure, functions, and livelihood attributes. After a series of robustness tests, the results still show that elite families significantly positively impact the area of land transferred out. Finally, based on the differences in land transfer areas and the consequences of different resource endowments, the corresponding countermeasures and suggestions are put forward from the aspects of strengthening grassroots governance, legal awareness, and establishing and improving the protection mechanism of vulnerable rural groups.
Flood Risk Assessment and Management in Urban Communities: The Case of Communities in Wuhan
Authors: Pan Wenyan , Yan Mengwei , Zhao Zhikun , Gulzar Muhammad Awais
Published: December 2022

The likelihood and uncertainty of severe rains and flooding in the middle basin of the Yangtze River have grown due to global warming and growing urbanization. A flood risk assessment index system is built based on resilience theory to assess community flood risk in a significantly changing environment, with communities serving as the primary body to manage flood risk in cities. The flood risk level of communities in Wuhan from 2011 to 2020 was assessed using the Analytic Hierarchical Process (AHP) and Dempster–Shafer (DS) evidence theory, utilizing an example of the typical Wuhan community. The findings indicate that: (1) The weight of hazard-causing factors is the largest and has the greatest influence on the risk of flooding in the community. (2) When looking at time series, the risk of hazard-causing factors gradually rises, while the risks associated with systemic governance, protective works, and community vulnerability steadily decline. Building resilient communities and enhancing flood risk management capability should be priorities for the government, local communities, and citizens.
Poorer Regions Consume More Undeveloped but Less High-Quality Land Than Wealthier Regions—A Case Study
Authors: Kirschner Vlaďka , Franke Daniel , Řezáčová Veronika , Peltan Tomáš
Published: December 2022

Despite the efforts of developed countries to protect undeveloped land, development continues to expand beyond urban boundaries. High-quality land needed for food production is often consumed. This study aims to verify possible causes of undeveloped land and high-quality land consumption within regions (NUTS3) using a new approach to building growth monitoring. It investigates residential (RBs) and commercial buildings (retail and industrial buildings, RIBs). The development between 2006 and 2016 in the Czech Republic, a country in Central Europe, is used as a case study. Population growth and gross domestic product per capita (GDP) within regions are considered two potential causes of land consumption; this hypothesis is verified using a linear regression model. Only GDP showed statistically significant results. It correlated negatively with RBs and RBs + RIBs built on undeveloped land and positively with RBs + RIBs and either RBs or RIBs built on high-quality land. Based on the results, we recommend that land protection policies be differentiated according to regional specifics to be more effective. Regions with lower GDPs should obtain more support in protecting undeveloped land against residential development. The protection of high-quality land should be emphasized by supporting residential and commercial development on brownfield sites in regions with higher GDPs.
Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
Authors: Emran Talha Bin , Islam Fahadul , Nath Nikhil , Sutradhar Hriday , Das Rajib , Mitra Saikat , Alshahrani Mohammed Merae , Alhasaniah Abdulaziz Hassan , Sharma Rohit
Published: December 2022

The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. The higher glutathione/oxidized glutathione ratio in 3-NP-induced rats is attributed to the ability of naringin to reduce hydroxyl radical, hydroperoxide, and nitrite. However, although progress has been made in treating these diseases, there are still global concerns about how to obtain a solution. Thus, natural compounds can provide a promising strategy for treating many neurological conditions. Possible therapeutics for neurodegenerative disorders include naringin and naringenin polyphenols. New experimental evidence shows that these polyphenols exert a wide range of pharmacological activity; particular attention was paid to neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, as well as other neurological conditions such as anxiety, depression, schizophrenia, and chronic hyperglycemic peripheral neuropathy. Several preliminary investigations have shown promising evidence of neuroprotection. The main objective of this review was to reflect on developments in understanding the molecular mechanisms underlying the development of naringin and naringenin as potential neuroprotective medications. Furthermore, the configuration relationships between naringin and naringenin are discussed, as well as their plant sources and extraction methods.
The Ameliorative Effect of Thymoquinone on Vincristine-Induced Peripheral Neuropathy in Mice by Modulating Cellular Oxidative Stress and Cytokine
Authors: Alenezi Sattam Khulaif
Published: December 2022

Thymoquinone (TQ), an active constituent of Nigella sativa, has been reported to exert a broad spectrum of pharmacological effects, including neuroprotective, anticancer, anti-inflammatory, antidiabetic, antiepileptic, antioxidant, and other modulatory roles in inflammation in experimental studies. The present study aims to evaluate the potential effects of TQ on vincristine-induced neuropathy in mice, as well as the possible role of oxidative stress, and pro- and anti-inflammatory cytokine in neuropathy development. A Swiss strain of male albino mice were randomly divided into seven groups, comprising of five animals each. Vincristine sulfate (0.1 mg/kg, i.p.) was administered for 10 consecutive days for the induction of peripheral neuropathy. The animals received their respective treatment of TQ (2.5, 5, and 10 mg/kg, p.o.) and pregabalin (10 mg/kg, p.o.) concurrently with vincristine for 10 days followed by 4 days post treatment. The animals were assessed for pain and related behavior on day 7 and 14 using hot and cold plates, and a rotarod test. TQ preventive treatment attenuated vincristine induced neuropathy in a dose dependent manner evidenced as a significant (p < 0.001) increase in reaction time on the hot plate and the cold plate, and a fall off time on the rotarod test. Further, TQ preventive treatment resulted in a significant (p < 0.001) reduction in the number of flinches and duration of paw elevation in a formalin test. Preventative treatment with TQ abolished the vincristine-induced rise in malondialdehyde and glutathione depletion in sciatic nerve tissue, as well as the blood IL-6 levels. In conclusion, TQ at 2.5, 5, and 10 mg/kg dose produced significant attenuation of neuropathic pain induced by vincristine which may be due to its antinociceptive, antioxidant, and anti-proinflammatory activity.
Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis
Authors: Ashruf Omer S. , Ansari Mohammad Yunus
Published: December 2022

Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability. There is no disease-modifying drug available for the treatment of OA. An ideal drug is expected to stop cartilage ECM degradation and restore the degenerated ECM. The ECM primarily contains type II collagen and aggrecan but also has minor quantities of other collagen fibers and proteoglycans. In OA joints, the components of the cartilage ECM are degraded by matrix-degrading proteases and hydrolases which are produced by chondrocytes and synoviocytes. Matrix metalloproteinase-13 (MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs 4 and 5 (ADAMTS5) are the major collagenase and aggrecanase, respectively, which are highly expressed in OA cartilage and promote cartilage ECM degradation. Current studies using various in vitro and in vivo approaches show that natural compounds inhibit the expression and activity of MMP-13, ADAMTS4, and ADAMTS5 and increase the expression of ECM components. In this review, we have summarized recent advancements in OA research with a focus on natural compounds as potential therapeutics for the treatment of OA with emphasis on the prevention of cartilage ECM degradation and improvement of joint health.