bluuebunny/crossref_metadata_2025 huggingface dataset:
Intracranial Pressure Monitoring in Patients With Traumatic Brain Injury: An Umbrella Review of Systematic Review and Meta-Analysis
Authors: Florez-Perdomo William A , Mishra Rakesh , Moscote-Salar Luis Rafael , Cincu Rafael , Maurya Ved Prakash , Agrawal Amit
Published: April 2024

Background: The objective of this study is to summarize the evidence in Cochrane and non-Cochrane systematic reviews, the effects, and the benefits of monitoring intracranial pressure (ICP) in patients with head trauma with an indication of ICP monitoringMethods: The process of preparing this overview followed the guidelines established by the Joanna Briggs Institute (JBI) for umbrella reviews. Two independent reviewers evaluated the quality of reporting, bias risk, methodologies, and evidence using three different tools: the Risk of Bias in Systematic Reviews (ROBIS) instrument, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and A Measurement Tool to Assess Systematic Reviews (AMSTAR 2). Results: A total of five papers met the criteria for inclusion in the study. These papers consisted of 49 primary research studies and 19 unique primary research studies. One of the SRs indicated that using intracranial pressure (ICP) monitoring led to a reduction in mortality. Two of the SRs had mixed results with temporal variation, while two found no significant difference in mortality with ICP monitoring. It is important to note that the quality of the SRs varied, with some being of higher quality than others.Conclusion: There was no conclusive evidence that ICP monitoring reduces mortality in TBI patients. There was high heterogeneity in included primary research studies. Future research should aim to address the limitations of these studies and provide more conclusive evidence regarding the effectiveness of ICP monitoring in reducing mortality in patients with traumatic brain injury.
ОЦІНКА ЕФЕКТИВНОСТІ АГРОПРОМИСЛОВИХ ЛАНЦЮГІВ ДОДАНОЇ ВАРТОСТІ У КРАЇНАХ З РИНКОВОЮ ТА ПЕРЕХІДНОЮ ЕКОНОМІКОЮ
Authors: Гуцул Тетяна , Суліма Наталія , Романов Андрій
Published: April 2024

Стаття присвячена темі формуванню ланцюгів доданої вартості в агропромисловому комплексі. Глобальні ланцюги доданої вартості (надалі ГЛДВ) тепер стали важливою частиною глобалізованої світової економіки. Враховуючи, що глобальні ланцюги мають значний вплив не лише на окремі компанії та транснаціональні корпорації, а й на цілі країни, важливо проаналізувати вплив на агропромисловий сектор кожної країни, що існує на глобальному рівні. Щоб ефективно працювати в цих умовах, компаніям необхідно змінити свої організаційні структури, аби підвищити гнучкість та формалізувати бізнес-процеси, особливо ті, що пов’язані з ланцюжком створення вартості. Мета статті – продемонструвати особливості формування ланцюгів доданої вартості під час виробництва продукції із сировини, отриманої в сільському господарстві. З огляду на можливості, які надають ланцюги доданої вартості країнам, що розвиваються, державні органи й агенції з розвитку розробили і впровадили різноманітні стратегії та програми з інтеграції ланцюгів доданої вартості, незважаючи на численні ризики та побоювання. Одні компанії зосереджені на розвитку ринку, інші – на вдосконаленні організаційної структури та підвищенні продуктивності, треті – на створенні мереж, іноземних інвестиціях, передаванні технологій і розвитку навичок. Активна участь у ГЛДВ дала змогу знизити бар’єри для входу на нижні ланки ланцюга створення вартості й інтеграції української промислової продукції до світового експорту, сприяла інтеграції української промислової продукції до світового експорту. З огляду на зміну географічних і продуктових векторів вітчизняного експорту, варто зазначити, що подальша участь України в міжнародній торгівлі залежить від зміцнення конкурентоспроможності вітчизняного ланцюга доданої вартості. Подальші дослідження мають бути спрямовані на розробку ефективних інструментів підтримки української промисловості в контексті сучасних торговельних угод.
RESEARCH STREAMS IN THE DOMAIN OF OMNICHANNEL IN MARKETING MANAGEMENT: BIBLIOMETRIC REVIEW
Authors: Жалінська Ірина
Published: April 2024

Omnichannel is viewed as a new approach to the company’s marketing activity in an integrated environment that combines online and offline channels. For now, the omnichannel environment is actively transforming. The article has outlined the extant areas of omnichannel research in marketing management to form a whole view of omnichannel. To achieve this goal, a bibliometric performance analysis provided by the SCOPUS database, scientific mapping utilizing the VOSviewer program, and exploring the most cited papers have been conducted. Based on a study of 1125 documents regarding omnichannel within the 2013–2023 period, the bibliometric field of omnichannel research has been conducted and visualized, including total documents produced, subject areas, most productive sources, most impactful authors, top relevant institution affiliations, production of papers by country, thematic clustering, and review of the most cited articles. The scientific interest in the omnichannel issue appeared in 2013, and since then it has been steadily increasing maintaining “Business, Management and Accounting” as the top position. The majority of docs were published in the USA, China, and India. There has not been identified a strong concentration of publications at any university as well as the most productive source. Six high-ranking thematic clusters have been identified, i.e. managing sales online and offline, dimension of marketing and marketing strategy, commerce, retailing, customer experience and satisfaction. The earliest topic is related to commerce, and the latest one is connected to customer satisfaction. The issues of competition in the omnichannel environment, impact of the omnichannel on retail operations, metrics for monitoring omnichannel marketing, creating a positive service experience, and logistics as an off-topic have been highlighted in the most cited articles. The obtained results allow substantiating the modern agenda of omnichannel issues and the most priority areas of its research, to determine the sources of its scientific and methodological support on the way to further development.
ЗАСТОСУВАННЯ ВЕЛИКИХ ДАНИХ ТА АНАЛІТИКИ ДЛЯ ОПТИМІЗАЦІЇ БІЗНЕС-ПРОЦЕСІВ І ЗНИЖЕННЯ ВИТРАТ
Authors: Овандер Наталія , Катуніна Ольга , Дідур Ганна
Published: April 2024

У нинішньому конкурентному бізнес-середовищі організації шукають інноваційні підходи для підвищення ефективності, скорочення витрат і отримання конкурентних переваг. Використання великих даних та аналітики стало ключовою стратегією у досягненні цих цілей. Мета статті – розглянути трансформаційний потенціал великих даних і аналітики в оптимізації різних бізнес-процесів у різних галузях, з’ясувати, як використання цих технологій може призвести до значного скорочення витрат, підвищення операційної ефективності та конкурентних переваг для організацій. У статті розглянуто актуальну проблему, пов’язану з необхідністю використання великих даних та аналітики, щоби залишатися конкурентоспроможними та розвиватися в цифрову епоху. Використовуючи величезні обсяги даних, отриманих з різних джерел, включно із взаємодією з клієнтами, операційними процесами та ринковими тенденціями, організації отримують корисну інформацію про свою діяльність та приймають обґрунтовані рішення. У цьому дослідженні розглянуто, як компанії різних галузей застосовують великі дані та аналітику для оптимізації процесів, виявлення недоліків та економії коштів у різних секторах економіки. Завдяки детальному аналізу тематичних досліджень і галузевих прикладів висвітлюються ключові стратегії та найкращі практики впровадження аналітики великих даних, що демонструють відчутні переваги, які отримують організації. Проаналізовані результати свідчать про значне покращення операційної ефективності, використання ресурсів і скорочення витрат, досягнуте завдяки впровадженню рішень на основі великих даних та аналітики. Використовуючи передові методи аналітики, такі як прогнозне моделювання, машинне навчання та візуалізація даних, компанії можуть проактивно виявляти можливості для оптимізації та зменшувати ризики. Розглянуто також виклики та обмеження, пов’язані з впровадженням великих даних і аналітики, зокрема, проблеми конфіденційності даних, нестача навичок та складнощі інтеграції. Водночас у статті наголошується на важливості подолання цих перешкод за допомогою стратегічних інвестицій у технології, розвиток персоналу та управління організаційними змінами. Зроблені висновки підкреслюють трансформаційний вплив великих даних і аналітики на сучасні бізнес-операції, акцентуючи їхню роль як каталізатора інновацій та конкурентоспроможності. Організації, які ефективно використовують силу інсайтів на основі даних, отримують стійку перевагу на сучасному ринку.
The Role of the Government's Self- Depth in Bearing Financial Pressures in Iraq for the Period (2006-2022)
Authors: Abdulkareem Abdulhussein Shatha , Mohammed Ali Abdullatif Emad
Published: April 2024

This study aimed at analyzing the government's self-financing depth in withstanding financial pressures in Iraq during the period (2006-2022). The study assumed that increasing government's financial capacity was having a positive impact on facing financial pressures of public expenditure burdens and economic non-stability in Iraq. The study relied on the inductive and data analysis method to verify the hypothesis of the study and access to results. With reference to the use of the ratio of oil revenues to GDP as deputy for self- financing depth due to the Iraqi government's heavy reliance on oil revenues to finance the general budget. It also used the following indicators as deputy financial pressure: the ratio of public expenditure, consumption, investment, and public debt to gross domestic product, tax effort index, monetary stability coefficient index and exchange rate discipline index. The study found that the financial capacity of the Iraqi government relied heavily on volatile self-financing depending on the volatility of oil revenues in financing current expenditures, which reduced the financial capacity to stand financial pressure. It’s reflected in the government's high financial burden and the existence of economic non-stability (inflation pressure, external debt pressure, foreign currency exchange pressure) in Iraq.
Paper type: Research paper.
Exploring Brand Loyalty in Online Shopping: The Context of Vietnam's Household Appliances Market
Authors: Dong Tan* Thai
Published: April 2024

In the dynamic e-commerce landscape, where online shopping has become a fundamental aspect of consumer behavior, a profound comprehension of the factors influencing brand loyalty is imperative for businesses striving to excel in the digital marketplace.This study aims to investigate the factors influencing brand loyalty of consumers in Viet Nam, with a specific focus on household appliance brands. Additionally, it seeks to elucidate the mediating role of customer satisfaction and brand trust in influencing brand loyalty. The study provides valuable information for developing effective brand strategies, helping strengthen customer loyalty, and increasing market share for home appliance brands. The research will employ a qualitative and quantitative approach, gather primary data through a structured questionnaire survey. The data analysis will be conducted using Smart PLS 4 and SPSS 26. The results of the study indicate that there are several factors influencing brand loyalty, including brand image, brand indentification, brand awareness, brand trust, and customer satisfaction. This underscores the importance of applying the research findings to optimize brand management and marketing strategies.
 
 
Paper type Research paper
A Diagnosis of the Local Administration Performance According to Satisfaction of the Local Citizens: A Case Study in Diyala Province – Iraq
Authors: Matook Abood Al-Mahdi* Mohammed
Published: April 2024

Paper type: Research paper
The purpose of this research is to diagnose the reality of the provided local performance by the local government and its impact on the local citizens' satisfaction in one of the Iraqi provinces (Diyala Province). The problem of this research was most local citizens that were not satisfied with the local performance of local governments in providing public services in most Iraqi provinces. The research methodology was the descriptive analytical approach by knowing the views and opinions of a sample of the local citizens that contained 1200 participants, where the research conducted the questionnaire as the main instrument. The data were analyzed by using appropriate statistical methods such as frequencies, percentages, and simple regression coefficients through the statistical program (SPSS. V.26). Several significant results address the gap between the local performance and citizens' satisfaction, where the critical result was the level of public satisfaction with the local performance of the local government is extremely weak, and most of the citizens are unsatisfied. The practical and social implications of the research may improve and develop the skills and abilities of the members of local governments by enrolling them in programs and workshops, particularly in public relations, public administration, non-profit, strategic planning, and local administration to build stronger communication and interaction between members of the government and the local community with specialist universities and institutes could lead to raising the level of the local performance and public satisfaction.
Designing a platform/adaptive randomised controlled trial for peripheral arterial disease (PAD) – The PAEDIS international platform trial development project
Authors: Saratzis Athanasios ,   PAEDIS development award consortium
Published: April 2024

Background Peripheral artery disease (PAD) is a common health problem. There are several technologies, medications, and interventions that aim to improve or treat PAD in people with symptomatic disease. Most of these technologies, however, have been untested in high-quality randomised studies assessing effectiveness and their interactions remain unknown. We developed a proposed design for an international randomised controlled trial assessing multiple PAD treatments. Methods Over the course of 11 months (2023) several workshops and reviews of the literature took place. More specific, the proposed platform trial was designed with 44 people with PAD and 112 experts from across the world, in five work packages. The most relevant PAD treatment with unproven effectiveness were identified and key trial components as well as success criteria were defined. With input from five clinical trials units, the final format of a potential platform PAD trial in primary and secondary care was then proposed for funding. Results The proposed platform PAD randomised trial involved two major multi-arm multi-stage randomised studies, assessing PAD treatments in the community setting (1st package) and then secondary care (2nd package). The 1st package involved people with claudication and the 2nd package involves people with chronic limb threatening ischaemia (CLTI). Conclusions A platform PAD trial involves many challenges in terms of both design and delivery. The proposed design involving both people with claudication and CLTI will hopefully act as a blueprint for future work in this area.
La mediación en el Ecuador, desafíos y oportunidades para la resolución de conflictos
Authors: León González Paola Elizabeth , Calle Masache Nube Catalina
Published: April 2024

Introducción: Este artículo académico examina el desarrollo y la relevancia de la mediación en Ecuador, resaltando su transformación desde la Ley de Mediación y Arbitraje de 1997. Se destaca la distinción que existe entre mediación y transacción, haciendo un enfoque en la legislación ecuatoriana que reconoce la transacción como un contrato para resolver aquellas disputas extrajudiciales. Se compara la experiencia de la mediación en México y España, resaltando las características y regulaciones que son específicas de cada país. Se concluye destacando perfiles de mediadores similares en México y España, subrayando la mediación como una herramienta valiosa para la resolución pacífica y eficiente de conflictos suscitados en el contexto ecuatoriano e internacional. Este enfoque integral proporciona una visión panorámica de la mediación, destacando su contribución a la construcción de un sistema de justicia accesible en Ecuador. Objetivos: analizar la mediación en el Ecuador, desafíos y oportunidades para la resolución de conflictos a través de la investigación descriptiva. Metodología: se realiza por medio del empleo de una metodología cualitativa y descriptiva. Resultados: los resultados de esta investigación se ven reflejados al aplicar la fórmula del ganar-ganar, ya que las partes que acuden a este proceso de mediación restablecen sus vínculos de forma ágil y menos engorrosa. Conclusiones: la mediación brinda un empoderamiento a las partes para resolver el conflicto, al ser autocompositiva se rige en la voluntad de las partes para llegar a un acuerdo y poder resolverlo. Área de estudio general: Derecho. Área de estudio específica: La mediación.
Perceptions On Nurses' Preparedness For Flooding Disasters: A Qualitative Study
Authors: Purnomo Edi , Gayatri Dewi , Setiawan Agus , Hamid Achir Yani S
Published: April 2024

Preparedness is a series of activities carried out to anticipate disasters through organization and through appropriate and effective measures with the expected result being a significant reduction in the risk and losses caused by disasters. This study aims to explore nurses' perceptions regarding readiness to respond to disasters, nurses' preparedness in facing disasters, the role of nurses in disasters, obstacles and support in providing disaster nursing services. A descriptive qualitative approach was used in this study. Purposive sampling was used to select 10 nurses for focus group discussions and four nurses for in-depth interviews. Data were collected from January to February 2024 and analyzed using content analysis. Readiness to respond to disasters includes two subcategories: disaster experience and reasons to immediately respond to disasters. Health workers' preparedness in facing disasters consists of four subcategories: early warning, collaboration, resources, development of specific training. The role of health workers in disasters consists of two subcategories: preparedness stage and response stage. In addition, obstacles and support in providing disaster services consist of two subcategories: obstacles experienced and support needed in providing nursing services when a disaster occurs. The findings of this study can serve as a basis for developing disaster preparedness enhancement programs for nurses and other health professionals. The results of the study can also be used as important evidence to encourage disaster health service policies in an effort to reduce risks caused by disasters with the involvement of stakeholders.
Anemia and Fatigue in Patients with Chronic Kidney Failure
Authors: Maisyaroh Arista , Maslufin M , Fibriyanti Dwi Ochta , Widianto Eko Prasetya , Kurnianto Syaifuddin
Published: April 2024

Chronic renal failure results in impaired kidney function, effectively eliminating metabolic waste and regulating fluid and electrolyte balance. The accumulation of waste metabolites is thought to impact the occurrence of anemia and fatigue. However, no research has shown a correlation between the incidence of anemia and fatigue in sufferers of chronic kidney failure. This study aimed to evaluate the relationship between hemoglobin levels and the degree of fatigue experienced by individuals diagnosed with chronic kidney disease. This research uses a cross-sectional study approach. The study population consisted of patients with chronic kidney failure at one of the hospitals in Lumajang Regency who were identified by the indicator of high BUN values. The sample size for this research was 50 people selected through purposive sampling. The data type used is primary data, with the independent variable being the Hb value, while the dependent variable is the level of fatigue in chronic kidney failure patients. The results of the Pearson correlation test in this study showed that there was a significant relationship between the percentage of hemoglobin levels in the blood and the level of fatigue in chronic kidney failure patients (p-value = <0,000; α = 0.05), with a strength of relationship 0,6092 which means the level Hemoglobin in the blood and the level of fatigue have a perfect degree of correlation. In patients with chronic renal failure and low hemoglobin levels, their fatigue levels will become more severe. Insufficient hemoglobin levels lead to a reduced count of red blood cells, causing a decline in the body's capacity to transport oxygen. This inadequate oxygen supply hampers the oxidation process and energy production in the form of ATP within the body's cells. Consequently, patients with chronic renal failure may undergo a substantial decrease in energy levels and experience significant tiredness.
The Effect of Muscle Energy Technique on Pain and Range of Motion in Patient with Knee Osteoarthritis
Authors: Komalasari Dwi Rosella , Handayani Tri Mukti
Published: April 2024

Osteoarthritis (OA) is a progressive degenerative joint disorder characterised by pain, stiffness, and limited range of motion (ROM). According to the World Health Organization (WHO), OA is one of the main causes of decreased quality of human life worldwide. Muscle Energy Technique (MET) is a treatment used to treat OA. This study aimed to determine the effect of MET on pain and ROM in knee OA patients. This research used a type of pra experimental research. The research group consisted of 15 patients with knee OA by purposive sampling who received the MET technique once a week for 4 weeks. Pain was measured by the Numeric Rating Scale (NRS), while a goniometer was used for evaluating the ROM of knee flexion and extension. There was a significant decrease in the average pain score before (4.7/10) and after (3.4/10) MET administration. LGS knee flexion increased by 7 degrees, while LGS knee extension decreased by 1.4 degrees. Statistically, MET positively reduces pain and increases ROM in knee OA (p<0.05). MET is one of the recommended techniques for health workers and physiotherapists in particular, in the management of reducing pain and increasing ROM for patients with knee OA
KONTRIBUSI KECEPATAN TENDANGAN, KEKUATAN OTOT TUNGKAI, KOORDINASI MATA DAN TANGAN TERHADAP SERANGAN ATLET PENCAK SILAT TAPAK SUCI SUMEDANG
Authors: Mahardika Willy Fitra
Published: April 2024

Penelitian ini bertujuan untuk 1) mengetahui pengaruh  kecepatan tendangan terhadap kombinasi serangan Atlit Pencak Silat Tapak Suci Sumedang.; 2) mengetahui engaruh  kekuatan otot tungkai terhadap kombinasi serangan Atlit Pencak Silat Tapak Suci Sumedang; 3) mengetahui  pengaruh yang diberikan kecepatan tendangan melalui koordinasi mata dan tangan terhadap kombinasi serangan Atlit Pencak Silat Tapak Suci Sumedang; 4) mengetahui pengaruh yang diberikan kekuatan otot melalui koordinasi mata dan tangan terhadap kombinasi serangan Atlit Pencak Silat Tapak Suci Sumedang; 5) mengetahui pengaruh yang diberikan keepatan tendangan dan kekuatan otot tungkai melalui koordinasi mata dan tangan terhadap kombinasi serangan Atlit Pencak Silat Tapak Suci Sumedang.  Metode penelitian yang digunakan adalah penelitian kuantitatif dengan pendekatan korelasi asosiatif. Penelitian ini tergolong pada jenis penelitian kuantitatif yang menggunakan teknik Analisis Jalur (Path Anaylisis). Yang dijadikan sampel dalam penelitian ini adalah Atlet Remaja Putra Pencak Silat Tapak Suci Sumedang yang berjumlah 64 orang.  Data yang diambil dalam penelitian ini menggunakan data primer dan sekunder. Data primer, merupakan data yang diperoleh atau di ambil secara langsung oleh peneliti melalui tes dan pengukuran terhadap variabel yang terdapat dalam penelitian. Data sekunder, merupakan data yang diperoleh berupa daftar nama atlet yang di dapat dari dokumen atau arsip. Teknik analisis data yang digunakan adalah menggunakan analisis Path atau analisis jalur. Hasil penelitian menemukan (1) Terdapat pengaruh langsung yang signifikan kecepatan tendangan terhadap koordinasi pukulan dan tendangan Atlet Pencak Silat Tapak Suci Sumedang ditunjukkan dengan koefisien r sebesar 0,681, dan signifikansi hubungan variabel X1 dengan variable Y dapat dilihat nilai t hitung sebesar 2.113 > dengan t tabel sebesar 1.701. Besar pengaruh kecepatan tendangan terhadap koordinasi pukulan dan tendangan pencak silat atlet tapak suci Sumedang adalah sebesar 46,31%.  (2) Terdapat pengaruh langsung yang signifikan kekuatan otot tungkai terhadap koordinasi pukulan dan tendangan pencak silat atlet tapak suci Sumedang ditunjukkan dengan koefisien r sebesar 0,759 dan signifikansi hubungan variabel X2 dengan variabel Y dapat dilihat nilai t hitung sebesar 2,309 > dengan t table sebesar 1,701. Besar pengaruh langsung Kekuatan otot tungkai terhadap Koordinasi pukulan dan tendangan Atlet Pencak Silat Tapak Suci Sumedang adalah sebesar 42,40%. (3) Terdapat pengaruh langsung yang signifikan koordinasi mata kaki terhadap Koordinasi pukulan dan tendangan Atlet Pencak Silat Tapak Suci Sumedang ditunjukkan dengan koefisien r sebesar 0,664, dan signifikansi hubungan variabel X3 dengan variable Y dapat dilihat nilai t hitung sebesar 1,997 > dengan t table sebesar 1,701. Besar  pengaruh koordinasi mata kaki terhadap Koordinasi pukulan dan tendangan Atlet Pencak Silat Tapak Suci Sumedang adalah sebesar 54,70%.
Neck pain among russian students
Authors: Naprienko M. V. , Zharashueva L. A. , Smekalkina L. V. , Chugunnikova S. M. , Alferova E. A. , Popovskaya E. A.
Published: April 2024

Objective. This study aims to analyze the prevalence and developmental factors of neck pain among students of Russian higher education institutions, with an emphasis on the impact of this pain on quality of life, academic activities, and overall well-being of students.

Materials and Methods. The study is based on data obtained from 780 students through a survey conducted on the Google Forms platform. Descriptive statistics and correlational analysis methods were applied, utilizing SPSS software for data processing.

Results. A high prevalence of neck pain among students (75.4 %) was identified. The analysis revealed a connection between neck pain and various aspects of life, including physical activity, stress, the use of mobile devices, and levels of physical activity. A correlation between neck pain and the psychosocial health of students was also established, particularly with anxiety and depression.

Conclusions. The study underscores the necessity of a comprehensive approach in the prevention and treatment of neck pain among students. The development of programs aimed at improving the physical and psychological health of students is recommended, including exercises for neck and back, lifestyle modification, and psychological support.
Open-label observational study of effectiveness and tolerability of ipidacrine in treatment of patients with diabetic polyneuropathy (DIAMANT study)
Authors: Samartsev I. N. , Zhivolupov S. A. , Markova M. N. , Chernoknizhnaya S. S.
Published: April 2024

Diabetic polyneuropathy (DPN) is one of the most common complications of diabetes mellitus, leading to the development of flaccid paresis, neuropathic pain syndrome, sensitive ataxia, as well as trophic disorders in the distal parts of the lower extremities.

The purpose of the randomized, open-label, comparative, prospective study was to evaluate the effectiveness and tolerability of ipidacrine in the complex treatment of patients with DPN.

Materials and methods. Patients with DPN (n = 60) were randomized into 2 groups. Both groups received basic therapy (alpha-lipoic acid, B vitamins, gabapentin); in the treatment of patients of the main group (n = 30), in addition, ipidacrine was used (Ipidacrine-SZ, North Star Co., Russia). We have analyzed the intensity of pain syndrome (VAS-P), the average daily dosage of gabapentin, and the results of the neuropathic dysfunctional scale (modified version, NDSm), Pittsburgh Sleep Quality Index, PSQI), Global Rating of Change Scale (GROC), the results of electroneuromyography (ENMG). The total duration of the observation and treatment period was 2 months.

Results. After 2 months of therapy in the main group of patients, compared with the control group, there was significantly more complete pain control (VAS-P: 3.0 ± 0.9 vs 3.6 ± 0.8), a decrease in the average daily dosage of gabapentin (390 vs 500 mg/day), reduction in the severity of clinical manifestations of polyneuropathic syndrome (NDSm: 4.4 ± 1.0 vs 4.9 ± 1.0 points) and improvement in sleep quality (PSQI: 6.8 ± 1.3 vs 7.9 ± 1.7). According to ENMG data, patients in the main group showed a significant improvement in the neurophysiological parameters of both motor and sensory fibers, which was significantly more pronounced compared to the control group. A significantly larger proportion of patients in the main group assessed the improvement from the therapy as ‘pronounced’ (GROC: 10/33.3 % vs 6/20.0 %).

Conclusions. The use of ipidacrine in complex therapy of patients with DPN can significantly reduce the clinical manifestations of disease and improve the neurophysiological parameters of the peripheral nerves of the lower extremities. Ipidacrine can be considered as a basic drug for the treatment of patients with neurological complications of diabetes mellitus.
Rhythmic transcranial magnetic stimulation in speech therapy correction in patients with autism spectrum disorder and delayed psychospeech development
Authors: Levunina E. S. , Kanshina D. S. , Badamshina E. V. , Krasilnikova E. V.
Published: April 2024

The relevance of the joint use of rhythmic transcranial magnetic stimulation (rTMS) and speech therapy correction in children with autism spectrum disorder (ASD) and delayed psycho–speech development (PSRR) is associated with the high frequency of occurrence of these nosologies. The work highlights the experience of a therapeutic multidisciplinary approach in the correction of delayed psychomotor and psychorechological development in children with (ASD) and (ZPRR).The combined use of rTMS and speech therapy classes turned out to be more effective in the group of children with (ASD) in terms of reducing psycho-emotional reactions, which made it possible to achieve a greater effect in impressive speech.
Some features of vitamin D content in arterial hypertension in patients with and without osteoarthritis of the knee joints
Authors: Tikhomirova N. Yu. , Eliseeva L. N. , Zhdamarova O. I. , Baste Z. A.
Published: April 2024

The aim of the study was to assess the relationship of serum vitamin D concentration with impaired cardiometabolic profile in hypertension in patients with and without osteoarthritis of the knee joints.

Materials and methods. The results of the examination of 196 patients aged 54.06±9.4 years with arterial hypertension (AH) were analyzed, who were divided into groups depending on the presence of osteoarthritis of the knee joints (OA KS): 1st–patients with AH (n=153) and 2nd–patients with AH+OA KS (n=43).All patients were assessed for the level of 25 (OH) D, biochemical parameters of blood plasma (total cholesterol, low and high density lipoproteins, triglycerides, creatinine), cardiac morphometry using ECHOCG.

Results. The proportion of people with adequate vitamin D levels was 1.2 times higher among patients with AH+OA CS (32.6 % vs. 26.1 %, p0.05). Additional vitamin D supplementation was significantly more common in the group of patients with AH+OA (0 % vs. 44 %, p<0.001).The subgroup with vitamin D deficiency in patients with hypertension without OA CS had the most unfavorable «cardiometabolic» profile (they had significantly high BMI, total cholesterol, and LVH).

Conclusions. In people with arterial hypertension (without OA CS), violations of vitamin D levels (deficiency or insufficiency) are associated with an unfavorable «cardio-metabolic» profile – they need additional testing of vitamin D levels in the blood and correction of the detected violations. The presence of pathology of the musculoskeletal system (OA CS) in patients with arterial hypertension, it had no effect on the level of vitamin D and the frequency of its individual disorders. However, in this cohort of patients (AH+OA), the use of vitamin D supplements was significantly more common (0 % vs. 44 %, p<0.001). The assessment of the effect of vitamin D supplementation on cardiometabolic status deserves further investigation. Patients with arterial hypertension and its combination with comorbid pathology have, on average, vitamin D levels classified as insufficiency.
Efficiency of the use of coordination training in the program of medical rehabilitation of patients after reverse shoulder endoprosthesis
Authors: Chugreev I. A. , Fesyun A. D. , Styazhkina E. M. , Rozhkova E. A.
Published: April 2024

The goal of this study. The goal is to evaluate the effectiveness of using upper limb coordination training after reverse shoulder arthroplasty.

Material and methods. 30 patients were examined in Federal State Budgetary Institution «National Medical Research Center for Rehabilitation and Balneology» of the Ministry of Health of the Russian Federation. They were examined in a long-term period after reverse shoulder arthroplasty (in 3–4 months) and were divided into two groups: the main and the comparison groups. All patients were similar in terms of gender and age. Their clinical and functional parameters of the shoulder joint were also comparable. The patients in the comparison group were treated with laser therapy, electrotherapy, massage, group exercises to train the upper limb and mechanotherapy. The patients in the main group additionally underwent coordination training with biological feedback to the shoulder joint.

The results of the study were evaluated according to the pain syndrome, functional activity of the shoulder joint, shoulder joint flexion angle and values of dynamic strength of the shoulder muscles. After the course of medical rehabilitation, the patients in both groups showed improvement of all clinical and functional parameters of the shoulder joint. There was a statistically significant improvement in the dynamic strength of the shoulder joint and reduction of pain syndrome in the patients in the main group.

Conclusions. The inclusion of shoulder coordination training allows to improve the rehabilitation results for the patients who undergo reverse shoulder joint arthroplasty.
Benign paroxysmal positional vertigo: case developed with hyperparathyreoidism and vitamin D deficiency
Authors: Bedenko A. S.
Published: April 2024

The most common cause of spinning vertigo is benign paroxysmal positional vertigo (BPPV). Most cases are related to idiopathic BPPV, which pathogenesis is still not fully understood. In this manuscript the clinical case of recurrent benign paroxysmal positional vertigo is depicted. BPPV in this case was occurred primary in menopausal period. A clinical feature of this case is its combination not only with vitamin D deficiency and postmenopausal osteopenia (confirmed according to osteodensitometry), but also with secondary hyperparathyroidism, laboratory confirmed. The literature has accumulated data to link the development and recurrence of BPPV with vitamin D deficiency and osteoporosis, but few comprehensive studies of all crucial indicators of calcium-phosphorus metabolism in these patients have been published. Meanwhile, according to the author, a comprehensive endocrinological study of calcium-phosphorus metabolism in a patient with newly diagnosed BPPV can help optimize therapy for this category of patients.
Regional aspects of autism morbidity in the Kabardino-Balkar Republic
Authors: Attaeva L. Zh. , Makarov I. V.
Published: April 2024

The article presents the results of a comprehensive scientific comparative analysis of the results of the study of statistical and epidemiological indicators of autism incidence in the population of the Kabardino-Balkar Republic for 2019–2021, which is of practical importance in describing the diverse manifestations of autism incidence dynamics on the territory of a separate region of the Russian Federation. The results of the study of the probable relationship of age, sex, place of residence and social everyday features with the prevalence of autism in the population of the Kabardino-Balkar Republic showed that autism is more prevalent among the child population of the Kabardino-Balkar Republic. The leading position among the identified cases of autism is in male children under 14 years of age living in urban settings. Any peculiarities in the change of living conditions were not revealed. This suggests a connection between autism and demographic indicators, with no connection with social features of residence in the region.
THE RELATIONSHIP BETWEEN PARENTING PRACTICES AND SLEEP HABITS OF SCHOOL AGE CHILDREN IN THE COVID-19 PROCESS
Authors: Koç Elif Simay , Kadiroğlu Türkan
Published: April 2024

ABSTRACT
This study was conducted to examine the relationship between parenting practices and sleep habits in school-age children. A cross-sectional, descriptive study was conducted between June - August 2021, with parents who have children 6–12 years old. The research group consisted of 352 parents. The study data was collected using a Personal Information Form, the Parenting Practices Scale, and the Children's Sleep Habits Scale. The average age of the parents was 35.95±5.99, and 71.9% were female. The average age of the children was 8.61±2.07, and 51.4% were girls. Parents scored a total of 164.98±16.03 points from the Parenting Practices Scale and 44.64±7.55 points from the Children's Sleep Habits Scale. A statistically significant, and negative correlation existed between the scores for the Parenting Practices and the Children's Sleep Habits (r:-0.409; p<0.01). As negative parenting practices increased, children's sleep problems increased. Nurses should educate parents regarding positive and negative parenting practices and their effects on children’s sleep habits.
Raising the bar: genus-specific nested PCR improves detection and lineage identification of avian haemosporidian parasites
Authors: Musa Sandrine , Hemberle Theo , Bensch Staffan , Palinauskas Vaidas , Baltrūnaitė Laima , Woog Friederike , Mackenstedt Ute
Published: April 2024

Avian haemosporidian parasites are useful model organisms to study the ecology and evolution of parasite-host interactions due to their global distribution and extensive biodiversity. Detection of these parasites has evolved from microscopic examination to PCR-based methods, with the mitochondrial cytochrome b gene serving as barcoding region. However, standard PCR protocols used for screening and identification purposes have limitations in detecting mixed infections and generating phylogenetically informative data due to short amplicon lengths. To address these issues, we developed a novel genus-specific nested PCR protocol targeting avian haemosporidian parasites. The protocol underwent rigorous testing utilizing a large dataset comprising blood samples from Malagasy birds of three distinct Passeriformes families. Furthermore, validation was done by examining smaller datasets in two other laboratories employing divergent master mixes and different bird species. Comparative analyses were conducted between the outcomes of the novel PCR protocol and those obtained through the widely used standard nested PCR method. The novel protocol enables specific identification of Plasmodium, Haemoproteus (Parahaemoproteus), and Leucocytozoon parasites. The analyses demonstrated comparable sensitivity to the standard nested PCR with notable improvements in detecting mixed infections. In addition, phylogenetic resolution is improved by amplification of longer fragments, leading to a better understanding of the haemosporidian biodiversity and evolution. Overall, the novel protocol represents a valuable addition to avian haemosporidian detection methodologies, facilitating comprehensive studies on parasite ecology, epidemiology, and evolution.
Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice
Authors: Maejima Yuko , Yokota Shoko , Yamachi Megumi , Misaka Shingen , Ono Tomoyuki , Oizumi Hiroaki , Mizuno Keita , Hidema Shizu , Nishimori Katsuhiko , Aoyama Masato , de Wet Heidi , Shimomura Kenju
Published: April 2024

The high prevalence of obesity has become a pressing global public health problem and there exists a strong association between increased BMI and mortality at a BMI of 25 kg/m2 or higher. The prevalence of obesity is higher among middle-aged adults than among younger groups and the combination of aging and obesity exacerbate systemic inflammation. Increased inflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha (TNFα) are hallmarks of obesity, and promote the secretion of hepatic C-reactive protein (CRP) which further induces systematic inflammation. The neuropeptide oxytocin has been shown to have anti-obesity and anti-inflammation effects, and also suppress sweet-tasting carbohydrate consumption in mammals. Previously, we have shown that the Japanese herbal medicine Kamikihito (KKT), which is used to treat neuropsychological stress disorders in Japan, functions as an oxytocin receptors agonist. In the present study, we further investigated the effect of KKT on body weight (BW), food intake, inflammation, and sweet preferences in middle-aged obese mice. KKT oral administration for 12 days decreased the expression of pro-inflammatory cytokines in the liver, and the plasma CRP and TNFα levels in obese mice. The effect of KKT administration was found to be different between male and female mice. In the absence of sucrose, KKT administration decreased food intake only in male mice. However, while having access to a 30% sucrose solution, both BW and food intake was decreased by KKT administration in male and female mice; but sucrose intake was decreased in female mice alone. In addition, KKT administration decreased sucrose intake in oxytocin deficient lean mice, but not in the WT lean mice. The present study demonstrates that KKT ameliorates chronic inflammation, which is strongly associated with aging and obesity, and decreases food intake in male mice as well as sucrose intake in female mice; in an oxytocin receptor dependent manner.
Shady solar: understanding barriers and facilitators to residential solar adoption for low- and moderate-income homeowners in New York City
Authors: Bansal Aditi , Dean Casey , Kahn Ellie , Sanchez Daphany Rose , Hernández Diana
Published: April 2024

Low- and moderate-income (LMI) households face substantial barriers in accessing solar energy despite incentives at the local, state, and federal levels. Notwithstanding the rapid deployment of resources, there is still much to understand and address from a program design and implementation perspective to effectively realize an equitable energy transition. This qualitative study, which draws on interviews with policymakers, implementers, and LMI homeowners, provides novel insights into barriers and facilitators surrounding the inclusive adoption of solar energy. Our findings underscore the substantial differences and frequent misalignments in perspectives among these stakeholders. We find that both implementers and LMI homeowners encounter economic and administrative burdens, though the specific ways these factors hinder solar adoption differ between the groups. We leverage the viewpoints and experiences of policymakers, implementers, and LMI homeowners to guide evidence-based recommendations to overcome the many hurdles that actively impede equitable and inclusive solar adoption.
Comparative analysis of multi-directional long-distance pollution transport effects on heavily polluted weather in the Liaoning region
Authors: Su Hang , Ren Kejin , Wang Jinhu , Lu Zhongyan , Lu Jinglong , Wang Dongdong , Wang Yuhao
Published: April 2024

In recent years, although the air quality in the Liaoning region has improved, heavy pollution weather is still caused by external pollution transportation. In order to study the influence of multi-directional long-distance pollution on the heavily polluted weather in Liaoning, this paper analyzes three types of transport channel (northerly, northwesterly, and southwesterly transport corridors) by combining ground observations, airborne observations, AQI and the concentration data of atmospheric pollutants such as PM2.5, PM10 and so on. The results show that both northerly and southwesterly winds caused widespread fog and haze in the Liaoning region. The PM2.5 concentration reached the second-highest value on record (1479 μg/m3) during the pollution period caused by northwesterly wind transport. Wind and sand transported from the northwest mainly caused dusty weather in Liaoning, with PM10 concentration reaching up to 1200 μg/m3 during the pollution period. Northeasterly and northwesterly wind transport mainly led to the accumulation of pollutants in high places to high pollution values. Convergence of winds due to southwesterly wind transport led to prolonged accumulation of pollutants in the Liaoning region, resulting in severe pollution. Long-distance pollution transport is now one of the main sources of heavy pollution in the Liaoning region.
Transcriptome analysis revealed potential mechanisms of channel catfish growth advantage over blue catfish in a tank culture environment
Authors: Wang Haolong , Su Baofeng , Zhang Ying , Shang Mei , Wang Jinhai , Johnson Andrew , Dilawar Hamza , Bruce Timothy J. , Dunham Rex A. , Wang Xu
Published: April 2024

Channel catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus) are two economically important freshwater aquaculture species in the United States, with channel catfish contributing to nearly half of the country’s aquaculture production. While differences in economic traits such as growth rate and disease resistance have been noted, the extent of transcriptomic variance across various tissues between these species remains largely unexplored. The hybridization of female channel catfish with male blue catfish has led to the development of superior hybrid catfish breeds that exhibit enhanced growth rates and improved disease resistance, which dominate more than half of the total US catfish production. While hybrid catfish have significant growth advantages in earthen ponds, channel catfish were reported to grow faster in tank culture environments. In this study, we confirmed channel fish’s superiority in growth over blue catfish in 60-L tanks at 10.8 months of age (30.3 g and 11.6 g in this study, respectively; p < 0.001). In addition, we conducted RNA sequencing experiments and established transcriptomic resources for the heart, liver, intestine, mucus, and muscle of both species. The number of expressed genes varied across tissues, ranging from 5,036 in the muscle to over 20,000 in the mucus. Gene Ontology analysis has revealed the functional specificity of differentially expressed genes within their respective tissues, with significant pathway enrichment in metabolic pathways, immune activity, and stress responses. Noteworthy tissue-specific marker genes, including lrrc10, fabp2, myog, pth1a, hspa9, cyp21a2, agt, and ngtb, have been identified. This transcriptome resource is poised to support future investigations into the molecular mechanisms underlying environment-dependent heterosis and advance genetic breeding efforts of hybrid catfish.