bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of depression, anxiety and Quality of life among North Indian Polycystic ovary syndrome Women: Evidence from a prospective observational study
Authors: Habib Sana , Anwar Arifa , Hoda Farazul , Verma Rishabh , Akhtar M. , Najmi Abul Kalam
Published: November 2021

Background: Polycystic ovary syndrome (PCOS) is a common heterogeneous gynaecological endocrine disorder characterized by clinical features including oligo-amenorrhea/ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology. PCOS increases the risk of depression and anxiety which leads to poor quality of life. Aim of the study were to determine the prevalence of anxiety and depression among women suffering from PCOS and to determine the quality of life (QOL) in PCOS women.Methods: The study was prospective, observational, non-interventional and questionnaire-based. 192 women with PCOS voluntarily helped in filling the questionnaires consisting of questions using PHQ-9 for depression, GAD-7 for anxiety, SF-12 for general health and PCOSQ-50 for disease-specific domains. All data were recorded in pre-designed case record forms and analysis of data was done using different statistical methods.Results: Majority of PCOS women were either overweight or obese. Based on PHQ-9 20% of women was suffering with major depression and based on GAD-7, 25% with major anxiety. It is found that psychosocial and emotional domain and coping domain of PCOSQ-50 is significant in patients with major depression and major anxiety. Significant effects were seen on their general health as per SF-12 domain. Lack of physical exercise was found in 83% of women.Conclusions: PCOS is a complex disease which decreases the overall quality of life. Therefore, treatment of PCOS women should include psychological counselling along-with with medication, especially in obese PCOS women. Women should be educated with the benefits of lifestyle modification in PCOS.
Podcasts as emerging tool for medical education: a critical perspective
Authors: Vijay Radhika , Gupta Namita
Published: November 2021

Background: Podcasts have started knocking the educational doors after setting their feet strong in entertainment grounds. There has always been a trend to welcome and introduce new ideas and innovative ways in medical education for the benefit of students. No doubts, they are an emerging tool for education. The study aims to know and evaluate critically the students’ perspective about the novel aural technology and its relevance to be included in the curriculum.Methods: A sample size of 110 undergraduate medical students enrolled in two private post graduate coaching centres in metropolitan regions of Delhi was taken to conduct the study. A semi structured pen and paper questionnaire was created and made to be filled by the participants.Results: Aware students actively participated in the survey and shared their preferences and opinions, but many lacked knowledge and interest in the newly introduced and conveyed audio technology. This was a direct result of their surroundings, friends and family circle. Generally, there was a welcome response towards podcasts being in trend and to be included as a supplementary teaching tool along with present ongoing modes of education.Conclusions: Students’ opinion taken over from time to time is of great value to introduce modern educational reforms. Podcasts are a very effective add-on tool if introduced in medical education. There still exists a wide room for research and evidence-based use of this technology and much work needs to be done to actually add a new brick in the current structure of medical education.
Toward Environment Theory: Post-Optimality and the Pragmatics of Affordance Design
Authors: Testov Dmitry
Published: November 2021

This article, devoted to the problems of the environment and intra-environmental processes, investigated various modes of interaction and interdependence of a living creature and the environment in which it lives. For these purposes, the conceptual apparatus of such theorists as G. Bateson, J. von Uexküll, J. Gibson, J. Deleuze and F. Guattari is used. Based on the analysis of a number of design and architectural projects the authors show that the processes of perception and action are not determined by the subject-object disposition. On the contrary, they emerge in the course of manifestation of the territorial assemblage. Such an assemblage consists of the environment and the organism, and is formed by the limitations, affordances and perceptual abilities of all its components. Within this framework the conceptual foundations of the design of the environment are proposed, based on the principle of economy. Applying the concept of "predictive mind" to modeling the information aspect of the relationship of the organism with the environment, the authors identify some characteristics of environment that could enhance and weaken the ability of the mind distributed in the environment to minimize errors predictions. Environment design is thus positioned as a practice of transforming oneself, and in contrast to optimal and friendly environments, the concept of a post-optimal environment is considered; such an environment is conducive to hacking and transformation. Through this notion of provocation to transformation the specificity and the conceptual significance of assistive technologies is revealed, transforming the relationship between people with disabilities and their environment.
Paternalistic orientations of russian students: political and psychological analysis
Authors: Turkov Egor
Published: November 2021

According to Russian researchers, paternalism is one of the "core" dominants of the Russian political culture and is its archetypal part, which, to some extent, still determines political thinking and behaviour of Russians. Meanwhile, in Russian political science the ideas about the essence of paternalism are simplified and do not take into account the fact that it is determined by specific needs, ideas, ideals and expectations that have political and cultural specifics. This work is aimed at a partial solution of this problem and contains the results of a political and psychological definition and an empirical study of the paternalistic orientations of Russian youth. The obtained data allow us to detect the actualized state of the paternalistic orientations of young Russians, expressed in high expectations from the state. The analysis of visual data also revealed an ambiguous, but mostly negative assessment of the state as a counterparty to Russian youth. Young people perceive the state as a stronger and older "person" who does not satisfy their request for protection, love and care. As a result, the mood of "disappointed paternalism", a desacralized image of the state and, to a lesser extent, the president are fixed in the mentality of young Russians. The state's performance of the functions of a "father" can become a promising tool for establishing effective and constructive interaction between state institutions and young Russians.
Dynamic Impact Analysis of Integrating a 6 MW Solar Photovoltaic Power Plant into Medium Voltage Distribution Network
Authors: Mohmmedali Abbas F.G. , Hamouda Messaoud , Touhami Ghaitaoui
Published: November 2021

In this paper, the impact of integrating a 6MW solar PV plant installed in Zaouiet Kounta (Wilaya Adrar), in southwest Algeria into a medium voltage network during transient conditions is analyzed. This network is fed by two sources, either a grid source or a conventional power plant if a grid source is not available. Three different transient circumstances are considered in this analysis. The impact on voltage and frequency at the network’s main busbar as well as generator rotor angle is investigated. The analysis is carried out on the network by using ETAP software. The analysis results showed that the integration of this PV plant has an adverse effect on network performance during transient conditions when a Conventional power plant is used to feed network. Moreover, it has a slight effect on main busbar voltage when a grid source is used to feed network.
Проблема физического воспитания и формирования здорового образа жизни подростков
Authors: Гафиятуллин Д.М. , Хайруллин И.Т.
Published: November 2021

В статье рассмотрены проблемы физического воспитания. Причины медленного формирования здорового образа жизни подростков. Влияние прогрессирующего мира на физическое воспитание ребенка. Отношение взрослого поколения к проблеме, а так же способы ее решения. Основные понятия и важность здорового образа жизни, его роль в формировании подростка.
Информационно-профессиональная компетентность в образовательном процессе
Authors: Косенюк И.А. , Гулякин Д.В.
Published: November 2021

В статье рассматриваются аспекты формирования информационно-профессиональной компетентности в образовательном процессе.
Развитие музыкально-ритмических способностей подростков с помощью технологии «body percussion» в условиях дополнительного образования
Authors: Котлова М.В.
Published: November 2021

В статье поставлена задача развития музыкально-ритмических способностей подростков в условиях дополнительного образования. Описано понятие музыкально-ритмических способностей, выделены компоненты музыкально-ритмической компетенции применительно к обучающимся подросткового возраста. В качестве технологии развития музыкально-ритмических способностей подростков предложено использовать технологию бодиперкуссия (body percussion). Описаны возможности применения бодиперкуссии в музыкальном образовании, систематизированы данные о ее продуктивности в развитии музыкально-ритмических способностей. Сформулированы педагогические условия применения данной технологии в дополнительном музыкальном образовании.
Экспериментальная проверка эффективности педагогических условий инновационного развития организаций начального общего образования в Республике Ингушетия
Authors: Султыгова Л.М. , Лезина В.В.
Published: November 2021

Предлагаемая широкой педагогической общественности статья содержит материалы экспериментальной проверки эффективности педагогических условий инновационного развития организаций начального общего образования в Республике Ингушетия. Такие условия включили: 1) повышение эффективности управления инновационной деятельностью организаций начального общего образования, 2) развитие творческой активности субъектов инновационной деятельности в названных организациях. В результате серии экспериментальных мероприятий (интервью с директором ГБОУ гимназии «Марем» г.Магаса, на базе которой проводился эксперимент, количественного и качественного анализа, наблюдения, аттестации педагогов на квалификационную категорию, творческого задания) была доказана эффективность названных условий.
How to Improve the Protection of Employees-Whistleblowers in Slovenia by Implementing the EU Whistleblower Protection Directive
Authors: Senčur Peček Darja
Published: November 2021

Workers and public employees reporting unlawful or harmful conduct in Slovenia are granted special protection only by specific acts, whereas they also enjoy general labour-law protection as employees. The paper addresses the state of their protection as provided by the applicable sectoral legislation relating to the prevention of corruption and to reporting of irregularities in banking and financial sectors, as well as by general labour legislation. Based on the analysis of the material and personal scope of the existing protection, the regulation of reporting channels, the possibility of public disclosure, the legally defined protective measures, and the institutional framework, the author adopts a position on the possibility to update this protection by proper implementation of the EU Directive 2019/1937.
Protection of Whistleblowers under Czech Law within the Context of the Directive on the Protection of Persons Who Report Breaches of Union law (2019/1937)
Authors: Morávek Jakub , Pichrt Jan
Published: November 2021

The chapter is focused on the protection of whistleblowers under Czech law within the context of the Directive on the protection of whistleblowers for persons who report breaches of Union law (2019/1937). Specifically, the chapter deals with all seven previous and current proposals for legal regulation of whistleblower protection. The authors provide a detailed discussion of the current draft of law to transpose Directive 2019/1937. The authors deal with the definition of the scope of the bill, retaliation measures, breadth of the obligation to implement a notification system, status of the responsible/concerned person in the notification system, absence of motivational measures and problematic aspects of public control.
Challenges in the Field of Whistleblower Personal Data Protection in Polish Law Compared to European Solutions
Authors: Bielak-Jomaa Edyta
Published: November 2021

In this chapter, the author presents the problem of the protection of whistleblowers’ personal data in the workplace in connection with the processing of their data in the channels for reporting breaches in the context of the transposition of the Directive on the protection of persons who report breaches of Union law into Polish law. The existing regulations ensure limited protection for employees and other individuals against retaliation or violation of privacy. The author postulates the necessity to develop comprehensive whistleblower legislation. The purpose of the legislation will be to oblige the employer to develop and implement solutions that will guarantee genuine confidentiality and protection of whistleblowers’ personal data.
Slovak Whistleblowing Law after Revision – a Step Forward?
Authors: Varga Peter , Zoričáková Veronika
Published: November 2021

In this chapter, the authors try to analyse the main aspects of the new Slovak Act on whistleblower protection No. 54/2019 Coll. Firstly, the authors highlight the fact that although Slovakia has a specialized Act regulating whistleblowing, other applicable legislation exists, as well. As it turns out, the antidiscrimination legislation still plays an important role, as the new Slovak Act does not cover all cases of whistleblowing protection. Furthermore, the authors analyse the personal and material scope of the provided protection and contemplate the connection between the definition of the whistleblower and the protection provided pursuant to the new Act. With regards to the material scope of protection, the act distinguishes between two kinds of anti-social activities depending on their severity. As it turns out, protection pursuant the new Act is provided only to whistleblowers reporting more serious anti-social activities. In other cases, the antidiscrimination legislation is the only platform for protection of such notifiers. Lastly, the new Act establishes both internal and external channels for reporting anti-social activities, with the new established Office for the Protection of Whistleblowers playing an important role. Although the Office is more or less only an administrative and monitoring body, it also grants specialized ex ante and ex post protection directly in labour law employer-employee relations and closely cooperates with relevant authorities competent for investigating criminal or administrative offences.
La creación de la marca de outsider como estrategia: Julio Guzmán en las elecciones presidenciales 2016
Authors:   , García Alarcón, Silvana Lucía
Published: November 2021

El objetivo principal del estudio es analizar la construcción de la marca de outsider del candidato a la presidencia del Perú Julio Guzmán como estrategia para consolidar la imagen de un líder político. Los líderes políticos deben tener en cuenta que la imagen personal no solo transmite mensajes, sino que también influye en las emociones del público. Este artículo se propone explicar la importancia de la creación de una marca como una estrategia dentro de los escenarios de la comunicación política. Asimismo, la presente investigación resalta el valor de la marca personal de un líder político y demuestra que ésta puede generar una identificación con el público, siendo capaz de transmitir ideas y emociones que ayudan a influir en el electorado. Con ayuda de un análisis cualitativo esta investigación se propuso demostrar la existencia de una relación entre la marca personal de outsider creada por Julio Guzmán y su plan comunicacional a través de la comunicación no verbal a la hora de transmitir su mensaje político.
Estudio y modelamiento hídrico de geomanta e hidrosiembra como reemplazo de los emboquillados en la carretera Lima-Canta
Authors:   , Mazco Cahuana Diana Elizabeth , Lecussan Urteaga Kriss Stephanie
Published: November 2021

La presente investigación consiste en evaluar y verificar la eficiencia anti-erosiva del revestimiento denominado geomanta e hidrosiembra como reemplazo de los emboquillados de piedra, presentes en las alcantarillas ubicadas en la carretera Lima - Canta. La primera metodología es de enfoque cualitativo, elaborada en campo mediante la recolección de datos mediante fichas, las cuales describen las características de 30 alcantarillas y la verificación del tipo de suelo. Seguidamente, se procesó la información recolectada donde se identificó 08 alcantarillas que presentaban problemas de erosión debido a la falla del emboquillado, posteriormente se procedió a obtener los caudales de diseño y se verifico su dimensionamiento. La segunda metodología presenta un enfoque cuantitativo, donde se determinaron los parámetros de velocidad y esfuerzo cortante generados por el flujo en la descarga de las alcantarillas, dichos valores fueron obtenidos mediante la aplicación de modelos hidráulicos en los programas HEC-RAS e IBER. Con la finalidad de proporcionar la solución adecuada que permita asegurar la estabilidad de la estructura, los valores de velocidades y esfuerzo cortante obtenidos fueron comparados con la resistencia brindada por el emboquillado y la geomanta. Los resultados permiten determinar que el emboquillado no presenta una resistencia adecuada para la protección en la descarga de las alcantarillas a media ladera. Finalmente, se recomienda el uso de geomanta e hidrosiembra para la protección de taludes de fuerte pendiente donde descarguen alcantarillas, en lugar de emboquillados los cuales no presentan resistencias adecuadas ante las velocidades y esfuerzos de corte producidas por el flujo de agua.
Funciones de fragilidad analíticas mediante análisis dinámico incremental para estimar la vulnerabilidad sísmica del pabellón frontal del Hospital Casimiro Ulloa
Authors:   , Aguilar Gonzales Ashily Gabriel , Gonzales Mejia George Hamiltong
Published: November 2021

El Perú, debido a su ubicación geográfica en el Cinturón de Fuego del Pacífico, es un país con alta sismicidad; lo que hace que nuestras edificaciones se encuentren experimentando la ocurrencia de sismos con mucha frecuencia. A lo largo de los años, dichos eventos no habrían liberado la energía sísmica acumulada en su totalidad, por lo que el país se encuentra en un silencio sísmico, a la espera de un sismo de gran magnitud. Asimismo, existen muchas edificaciones esenciales, tales como hospitales, que fueron construidos antes de la emisión de la primera norma de Diseño Sismorresistente en 1970; siendo diseñadas posiblemente solo considerando cargas de gravedad. Es por esta razón que se tiene la incertidumbre de cuán preparadas están dichas edificaciones esenciales ante la ocurrencia de próximos eventos sísmicos de gran magnitud Este estudio presenta una serie de metodologías de tratamiento de registros sísmicos, modelamiento no lineal de una estructura de albañilería artesanal y su calibración con resultados experimentales, aplicación del análisis dinámico incremental (IDA) y proceso estadístico de los resultados. Todo ello para generar funciones de fragilidad analíticas que permitan estimar la probabilidad de exceder cada estado de daño para una determinada demanda sísmica. Los resultados muestran que las funciones de fragilidad analíticas son una herramienta útil para estimar la vulnerabilidad sísmica, puesto que se obtuvo altas probabilidades de colapso en ambas direcciones ortogonales.
Somut Olmayan Kültürel Mirasın Eğitim Programlarına Yansıması: Hayat Bilgisi Öğretimi
Authors: YILDIRIM Gülsüm
Published: November 2021

Bu araştırmada 2018 hayat bilgisi öğretim programının kazanımları ile 2020-2021 öğretim yılında Milli Eğitim Bakanlığı onayı ile uygulanan ders ve çalışma kitaplarında yer alan metin ve görsellerin somut olmayan kültürel mirasa dönük ögelerinin incelenmesi amaçlanmıştır. Araştırmada doküman incelemesi yöntemiyle 2020- 2021 öğretim yılında bir, iki ve üçüncü sınıf hayat bilgisi ders ve çalışma kitabı olarak kullanılmasına karar verilen kitaplar ve 2018 hayat bilgisi öğretim programı kazanımları incelenmiştir. Araştırma sonucunda; birinci ve ikinci sınıf kazanımları ele alındığında sadece iki kazanımın, üçüncü sınıf için ise yalnızca bir kazanımın somut olmayan kültürel mirasın kazandırılabileceğine dair açıklamaları yer aldığı görülmektedir. Birinci sınıf için hazırlanan ders ve çalışma kitaplarındaki metin ve görsellerde halk bilgisi, toplumsal uygulamalar ve gösteri sanatlarına yer verilirken, ikinci sınıf için hazırlanan el sanatları ve sözlü anlatımlara dönük metin ve görseller bulunmaktadır. Bununla birlikte üçüncü sınıfta somut olmayan kültürel mirasa dönük metin veya görsele çok az yer verilmekle birlikte halk bilgisi, sözlü anlatımlar ve toplumsal uygulamalar bulunmaktadır.
Seedling physiological responses from Ceiba glaziovii (Kutze) K. Skum. to intermittent drought events
Authors: Oliveira Maria Fernanda da Costa , Santos Júnior José Laurindo dos , Freitas Rafael Silva , Silva Elizamar Ciríaco da
Published: November 2021

The Brazilian Dry Tropical Forest, called Caatinga, has several environmental conditions limiting plant growth and development, requiring the plants that inhabit this phytogeographic domain, physiological and morphological traits to guarantee the perpetuation and survival of the species. The objective of the present work was to evaluate the growth parameters in Ceiba glaziovii, a tree species that occurs in the Caatinga, submitted to intermittent drought. For such seedling of C. glaziovii were subjected to different cycles of irrigation suspension [Control- daily irrigation, S7- irrigation every seven days and SS - total suspension of irrigation until signs of wilt appear]. Height, number of leaves, stem diameter, dry matter of the various organs, root / shoot ratio, leaf area, and the index of plasticity were evaluated. The prolongation of intermittent drought had a significant reducing effect on the growth rates, dry matter production and leaf area of stressed C. glaziovii seedlings compared to daily watering ones. Plant height and stem diameter were the most plastic traits found (IP>0,8). Thus, watering intervals above seven days may severely compromise the production of C. glaziovii seedlings, affecting the growth rates until the accumulation of dry matter. These results demonstrate that this species does not show great tolerance to drought stress during the initial period of its development, suggesting for cultivation of seedlings an adequate water availability or an interval of up to seven days between watering.
Secagem de toras de clones de Eucalyptus urograndis em estufa solar
Authors: Silva Matheus Alexandrino José da , Brito Dáfilla Yara Oliveira de , Souza Jaltiery Bezerra de , Gomes João Paulo Silva , Nunes Lucas Jean , Ucella-Filho João Gilberto Meza , Azevêdo Tatiane Kelly  Barbosa de
Published: November 2021

A secagem é uma etapa importante no processo da industrialização da madeira, tendo como finalidade melhorar a qualidade do material. Porém, é um processo oneroso havendo a necessidade da redução dos seus custos, por meio de métodos que demandem menos investimento. Desse modo, os objetivos deste estudo foram avaliar a eficiência de estufa solar na secagem de toras de clones de Eucalyptus urograndis instalada no município de Macaíba, estado do Rio Grande do Norte, com o intuito de verificar se a região é adequada para esta prática; e ii) avaliar a influência de diferentes classes de diâmetro das toras no processo de secagem. Foram seccionadas toras de 1,50m e separadas em função de quatro classes de diamétricas. Em seguida foram pesadas e acondicionadas em estufa solar, sendo realizado medições diárias da temperatura e umidade relativa do ar e pesagens quinzenais durante o período de observação até que atingissem o ponto de saturação das fibras. Os dados foram submetidos a análise de regressão, aplicando-se o procedimento de seleção de variáveis. Aos 35 dias, todas as toras já haviam atingido o PSF. Entretanto, as medidas do diâmetro não afetaram significativamente na secagem, que se demonstrou eficiente quando comparada aos métodos convencionais e naturais. Portanto a secagem de toras em estufa solar torna-se um método viável para região.
Study of the composition of mango pulp and whey for lactic fermented beverages
Authors: Maldonado Rafael Resende , Buosi Roberto Elias , Avancini Neto Octávio , Araújo Ramon dos Santos , Deziderio Marcela Aparecida , Aguiar de Oliveira Elizama , Petrus Rodrigo Rodrigues , Kamimura Eliana Setsuko
Published: November 2021

Fermented lactic beverages have high sensory acceptance and may present probiotic microorganisms that are able to promote well-being. Milk is the primary substrate for this type of fermentation. However, more and more, consumers have been requesting for alternative formulations with lower (or absent) milk content. Two nutritional components can allow the reduction of milk in formulations: cheese whey (CW) and fruit pulps. Thus, this study aimed to investigate, with the aid of the experimental design tool and sensory analysis, the best formulations between mango pulp (MP), CW and whole milk (WM) to develop lactic beverages fermented by Lactobacillus acidophilus La-5 at 37 °C for up to 72 h. The results indicated that the increase in MP proportion associated with a decrease in WM elevated the sensory acceptance. Three formulations, with 24 h of fermentation, containing 55 – 100 % (w/w) of MP and 0 – 45 % (w/w) of CW were the best formulations and presented pH of 3.5 – 4.0, cell count >108 CFU/mL and 82 – 88 % of global acceptance. These results suggest MP or MP with CH as substrates for lactic fermentation replacing milk.
Análise fitoquímica e avaliação da atividade antioxidante do extrato foliar de Cariniana estrellensis
Authors: Ribeiro Antonio Vycttor de Pádua , Leite Filho César Auladino Leite Filho , Garcia Jordana Lucio , Silva João Victor Morais , Aguiar Aline Aires
Published: November 2021

A variedade dos metabólitos secundários que constituem as plantas, principalmente os com ação  antioxidante, são de suma importância para o uso de seus extratos e moléculas isoladas na prevenção de doenças. Devido à ação antioxidante de compostos secundários, como os fenólicos e os cumarínicos, presentes nos extratos de muitas plantas, há uma relação com a redução dos danos oxidativos celulares originados por espécies reativas de oxigênio e nitrogênio, sendo a Cariniana estrellensis, que é também popularmente conhecida como jequitibá-branco, rica em fitocompostos do metabolismo secundário. Trata-se de uma espécie arbórea climática neotropical, predominante no cerrado brasileiro, na qual tem uso medicinal recomendada para inflamações de mucosas e faringite. Este trabalho teve como objetivos determinar e caracterizar os compostos químicos presentes nas folhas de C. estrellensis e avaliar a atividade antioxidante delas. Na avaliação da atividade antioxidante, foi utilizado o método de sequestro do radical livre DPPH (1,1-Difenil-2-picril-hidrazil). O conteúdo fenólico total foi quantificado pelo método de Folin-Ciocalteu em conjunto com o método de precipitação da caseína. Com os percentuais dos compostos secundários, principalmente os de ação antioxidante, e a capacidade de sequestro de hidrogênio , demonstrou-se que o extrato foliar de Cariniana estrellensis tem efeito análogo ao do ácido ascórbico, um potente antioxidante encontrados em frutas cítricas.
Principais cadeias produtivas para o desenvolvimento da agroenergia no Norte do Brasil: limitações e perspectivas
Authors: Souza Micaele Rodrigues de , Oliveira Gabriel Duarte de , Sousa Rosinete Nogueira de , Almeida Tamyres Siglya Sousa de , Santos Ana Elisa Esteves dos , Ságio Solange Aparecida
Published: November 2021

Pesquisas voltadas para a bioenergia foram intensificadas na tentativa de cumprir as metas definidas pelo Protocolo de Kyoto (1997). Os biocombustíveis representam um dos ramos da bioenergia e entre os elos da cadeia produtiva dos biocombustíveis, o elo agrícola se destaca por ser o principal componente da formulação do preço final do combustível, havendo assim a necessidade de se buscar matérias-primas que colaborem para a redução dos preços, além de possibilitar a descentralização da produção. A região Norte do Brasil, especificamente, detém uma ampla variedade de espécies, que se apresentam como opções viáveis para a redução da dependência de combustíveis fósseis. Desta forma, trabalhos voltados para o estudo das cadeias do biodiesel e do etanol, principalmente desses elos, são essenciais, a fim de verificar fatores limitantes, bem como suas potencialidades. Portanto, objetivou-se elaborar uma revisão bibliográfica sobre a cadeia produtiva do biodiesel e etanol, visando apontar os principais fatores limitantes, potenciais e perspectivas para o desenvolvimento da agroenergia na região Norte. Sendo possível concluir que as perspectivas são positivas para o desenvolvimento da agroenergia na região Norte, por meio das culturas descritas. No entanto, fatores contribuem para a limitação de gargalos que demandam desenvolvimento tecnológico, planejamento e incentivo governamental, a fim de expandir a cadeia produtiva de biocombustíveis na região Norte.
Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O
Authors: Hamdi Najlaa , Chaouch Souad , da Silva Ivan , Ezahri Mohamed , Lachkar Mohammed , Alhasan Rama , Abdin Ahmad Yaman , Jacob Claus , Bali Brahim El
Published: November 2021

A novel hybrid cobalt phosphite, (H2DAB)[Co(H2PO3)4]·2H2O, has been synthesized by using slow evaporation method, in the presence of cobalt nitrate, phosphorous acid and 1,4- dia-minobutane (DAB= 1,4- diaminobutane) as a structure-directing agent. Single crystal X-ray diffraction analysis showed that the compound crystallizes in the P-1(n.2) triclinic space group, with the following unit cell parameters (Å, °) a = 5.4814 (3), b = 7.5515 (4), c = 10.8548 (6), α = 88.001 (4), β = 88.707 (5), γ = 85.126 (5), and V= 447.33 (4) Å3. The crystal structure was built up from cor-ner-sharing [CoO6] octahedra, forming chains parallel to [001], which are interconnected by H2PO3 pseudo-tetrahedral units. The deprotonated cations, residing between the parallel chains, interacted with the inorganic moiety via hydrogen bonds leading thus to the formation of the 3D crystal structure. The Fourier transform infrared spectrum showed characteristic bands corresponding to the phosphite group and the organic amine. The thermal behavior of the compound consisted mainly of the loss of its organic moiety and the water molecules. The biological tests exhibited significant activity against Candida albicans and Escherichia coli strains in all used concentrations, while less inhibitory activity was pronounced against Staphylococcus epidermidis and Saccharomyces cerevisiae, and in the case of multi-cellular organisms, no activity against the nematode model Steinernema feltiae was detected.
Extraction of the Relations between Significant Pharmacological Entities in Russian-Language Internet Reviews on Medications
Authors: Sboev Alexander , Selivanov Anton , Moloshnikov Ivan , Rybka Roman , Gryaznov Artem , Sboeva Sanna , Rylkov Gleb
Published: November 2021

Nowadays, an analysis of virtual media to predict society’s reaction to any events or processes is a task of great relevance. Especially it concerns meaningful information on healthcare problems. Internet sources contain a large amount of pharmacologically meaningful information useful for pharmacovigilance purposes and repurposing drug use. An analysis of such a scale of information demands developing the methods that require the creation of a corpus with labeled relations among entities. Before, there have been no such Russian language datasets. This paper considers the first Russian language dataset where labeled entity pairs are divided into multiple contexts within a single text (by used drugs, by different users, by the cases of use, etc.), and a method based on the XLM-RoBERTa language model, previously trained on medical texts to evaluate the state-of-the-art accuracy for the task of indication of the four types of relationships among entities: ADR–Drugname, Drugname–Diseasename, Drugname–SourceInfoDrug, Diseasename–Indication. As shown based on the presented dataset from the Russian Drug Review Corpus, the developed method achieves the F1-score of 81.2% (obtained using cross-validation and averaged for the four types of relationships), which is 7.8% higher than the basic classifiers.
On the Emergence of Spacetime and Matter from Model Sets
Authors: Amaral Marcelo , Fang Fang , Aschheim Raymond , Irwin Klee
Published: November 2021

Starting from first principles and the mathematics of model sets we propose a framework where emergence of spacetime and matter can be addressed.
Radiosensitizer Effect of β-Apopicropodophyllin Against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis
Authors: Lee Na-Gyeong , Kwon Jin-Hee , Kang A-Ram , Song Jie-Young , Hwang Sang-Gu , Um Hong-Duck , Kim Joon , Park Jong Kuk
Published: November 2021

β-apopicropodophyllin (APP), a derivative of podophyllotoxin (PPT), has been identified as a potential anti-cancer drug. This study tested whether APP acts as an an-ti-cancer drug and can sensitize colorectal cancer (CRC) cells to radiation treatment. APP had an anti-cancer effect against the CRC cell lines HCT116, and DLD-1, SW480 and COLO320DM with IC50 values of 7.88 nM, and 8.22 nM, 9.84 nM and 7.757 nM, respec-tively induction of DNA damage. Colonogenic and cell counting assays indicated that the combined treatment of APP and γ-ionizing radiation (IR) showed greater retardation of cell growth than either alone, suggesting that APP sensitizes CRC cells to IR. Annexin V-propidium iodide (PI) assays and immunoblot analysis showed that the combined treatment of APP and IR increased apoptosis in CRC cells compared with either APP or IR alone. Results obtained from the xenograft experiments also indicated that the combination of APP and IR enhanced apoptosis in in vivo animal model. Apoptosis induction by the combined treatment of APP and IR resulted from reactive oxygen species (ROS). Inhibition of ROS by N-acetylcysteine (NAC) restored cell viability and decreased the induction of apoptosis by APP and IR in CRC cells. Taken together, these results indicate that a combined treatment of APP and IR might promote apoptosis by inducing ROS in CRC cells.
Telomere Targeting Approaches in Cancer: Over the Length Maintenance.
Authors: Vertecchi Eleonora , Rizzo Angela , Salvati Erica
Published: November 2021

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. Telomere length homeostasis is critical for cancer development then telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere’s dysfunction impinges on intracellular signalling pathways, in particular DNA damage signalling and repair affecting cancer cell survival and proliferation. This review summarizes and discusses about the recent findings in anti-cancer drug development targeting different “telosome” components.
Assessing the Acceptability of a Co-produced Long COVID Intervention in an Underserved Community in the UK
Authors: Fowler-Davis Sally , Young Rachel , Maden-Wilkinson Tom , Hameed Waqas , Dracas Elizabeth , Hurrell Eleanor , Bahl Romila , Kilcourse Elisabeth , Robinson Rebecca , Copeland Robert
Published: November 2021

Background: The COVID-19 pandemic has disproportionately affected people from more deprived communities. The experience of Long Covid is similarly distributed but very few investigations have concentrated on the needs of this population. The aim of this project was to co-produce an acceptable intervention for people with Long Covid, living in communities recognised as more deprived. Methods: The intervention was based on a multi-disciplinary team using approaches from sport and exercise medicine and functional rehabilitation. The co-production process was undertaken with a stakeholder advisory group and patient public involvement representation. This study identified participants by postcode and the indices of multiple deprivation (IMD); recruitment and engagement were supported by an existing health and wellbeing service. A virtual ‘clinic’ was offered with a team of professional practitioners who met participants three times each; to directly consider their needs and offer structured advice. The acceptability of the intervention was based on the individual’s participation and their completion of the intervention. Results: Ten participants were recruited with eight completing the intervention. The partnership with an existing community health and wellbeing service was deemed to be an important way of reaching participants. Two men and six women ages ranging from 38 to 73 were involved and their needs were commonly associated with fatigue, anxiety and depression with overall de-conditioning. None reported serious hardship associated with the pandemic although most were in self-employment/part-time employment or were not working due to retirement or ill-health. Two older participants lived alone, and others were single parents and had considerable challenges associated with managing a household alongside their Long Covid difficulties. Conclusions: This paper presents the needs and perspectives of eight individuals involved in the process and discusses the needs and preferences of the group in relation to their support for self- managed recovery from Long Covid.
Mast Cell Response to Leishmania mexicana and Sand Fly Salivary Proteins is Modulated by Androgens
Authors: Sánchez-García Laura , Perez-Torres Armando , Muñoz-Cruz Samira , Morales-Montor Jorge , Becker Ingeborg
Published: November 2021

Mast cells (MCs) play a crucial role during infections with Leishmania, that is transmitted through the bite of an infected sand fly that injects saliva together with the parasite. Sand fly saliva is a complex fluid that modulates the host immune response. In addition, hormonal factors modulate the host immune response, impacting the susceptibility to infections. Thus, to assess the impact of androgens and salivary proteins of sand fly vectors on the mast cell (MC) response to Leishmania infections, we infected orchiectomized male mice with the parasite in the presence or absence of sand fly salivary proteins and analyzed the inflammatory response of MCs. Our results showed a differential MC response to the parasite and to vector salivary proteins in mice deprived of gonadal hormones, as compared to sham-operated mice. Orchidectomy induced a different pattern of activation in MC of animals infected with Leishmania and vector-salivary proteins. Our results show that during Leishmania infection, androgens modulate the innate immunity response against the parasite and salivary proteins of the sand fly vector.
Kepatuhan Pengobatan Terhadap Indeks Glikemik Kontrol Pada Pasien Diabetes Melitus Tipe II di Rumah Sakit Islam Sultan Agung Semarang
Authors: Sa’dyah Nur Anna Chalimah , Sabiti Farroh Bintang , Susilo Sandra Thertianing
Published: November 2021

Diabetes Melitus ialah penyakit yang ditandai dengan nilai kadar HbA1c >7%. Hampir 80% pasien Diabetes Mellitus Tipe II mengalami kematian. Kepatuhan dalam meminum obat merupakan peran penting bagi penderita penyakit Diabetes Melitus tipe II. Perlu adanya peningkatan kepatuhan dalam penggunaan obat sehingga keberhasilan dalam pengobatan tercapai serta nilai kadar indeks glikemik yang terkontrol. Tujuan penelitian ini adalah untuk mengetahui hubungan kepatuhan penggunaan obat dengan indeks glikemik kontrol pada pasien Diabetes Melitus di Rumah Sakit Islam Sultan Agung Semarang. Penelitian ini merupakan penelitian pra-eksperimental dengan rancangan The one Group Pretest-Posttes dilakukan secara cross sectional. Sampel sebanyak 96 pasien yang diberikan kuisioner kepatuhan ARMS diambil di Rumah Sakit Islam Sultan Agung Semarang Pengambilan data dilakukan pada periode Agustus-Oktober 2020 di Rumah Sakit Islam Sultan Agung Semarang. Penelitian ini didapatkan hasil 0,000 yang dikatakan terdapat indeks glikemik kontrol HbA1c pada pasien Diabetes Melitus type II di Rumah Sakit Islam Sultan Agung Semarang menunjukan nilai p 0,000 (p < 0,05) bahwa terdapat hubungan kepatuhan penggunaan obat dengan Indeks glikemik kontrol kadar HbA1c.
Tensile Failure and Fracture Width of Partially Permeable Wellbores with Applications in Lost Circulation Material Design
Authors: Nguyen Kien , Mehrabian Amin , Santra Ashok , Phan Dung
Published: November 2021

Estimation of near-wellbore fracture widths remains central to designing the particle size distribution (PSD) and composition of lost circulation material (LCM) blends. Although elastic rock models are often used for this purpose, they fall short in capturing the substantial effect of pore fluid pressure on the fracture width. The problem is addressed in this paper by incorporating the poroelastic back stress in width estimation of axial fractures nearby an inclined wellbore. The poroelastic back stress is caused by a nonideal drilling fluid filter cake allowing for fluid pressure communication between the wellbore and pore space of the rock surrounding the wellbore. In this aspect, a proper definition of the filter-cake efficiency is made in terms of the wellbore pressure, far-field pore fluid pressure, and pore fluid pressure of the rock surrounding the wellbore. The value of this parameter is estimated from the standard drilling fluid filtration test results, as well as the formation rock permeability. The filter-cake efficiency is next used to develop the long-time, asymptotic analytical solution for the poroelastic stress of an inclined wellbore. By accounting for the obtained poroelastic back stress, an improved estimation of the wellbore tensile limit that depends on the filter-cake efficiency parameter is developed. For wellbore pressures beyond the wellbore tensile limit, the width of the near-wellbore fractures is estimated. The fracture width estimation is made through an analytical, dislocation-based fracture mechanics solution to the integral equation describing the nonlocal stress equilibrium along the fracture faces. The commonly practiced scheme for geometric design of LCM blends is enhanced by using the presented improvement in estimation of the near-wellbore fracture width. A case study is used to demonstrate the substantial effect of drilling fluid filtration properties and the resulting poroelastic back stress on the wellbore tensile limit, estimated fracture width, and consequently, composition of the recommended LCM blend.
A New Analytical Approach To Calculate a Slippage inside a Progressing Cavity Pump with a Metallic Stator Using a Middle Streamline and a Structural Periodicity
Authors: Om Il Lyong , Han Un Chol , Ryo Song Il , Kim Chun Yong , Sol Yong Nam
Published: November 2021

Simplified and 3D models have been studied to predict the performance of progressing cavity pumps (PCPs). Simplified models were mainly made for metallic stator PCP performance. Their purpose was to represent the relationship between pump flow rate and differential pressure. Previous studies proposed to solve the system of mass conservation equations. In these studies, the geometry of the gap area was not clearly represented by neglecting the curvatures of stator and rotor. In addition, only frictional loss was considered, but local loss by gradual contraction or expansion of the gap area was not considered.

In this study, we present a new analytical approach considering curvature and local loss. The depth of the gap area and local loss could be calculated analytically by a middle streamline and a curvature. On the basis of periodicity of distribution of cavities, simplified calculation for a slippage was possible without a system of mass conservation equations. Therefore, this model represents clearer geometry and a more simplified approach. The results show that this model shortens the calculating time and facilitates programing; in addition, the model validation is good in matching with experimental data.
Mass spectrometry-based proteomic analysis of NSCLC tumor and biopsy samples
Authors: Lehtiö Janne , Arslan Taner , Siavelis Ioannis , Pan Yanbo , Socciarelli Fabio , Berkovska Olena , Umer Husen M. , Mermelekas Georgios , Pirmoradian Mohammad , Jönsson Mats , Brunnström Hans , Brustugun Odd Terje , Purohit Krishna Pinganksha , Cunningham Richard , Asl Hassan Foroughi , Isaksson Sofi , Arbajian Elsa , Aine Mattias , Karlsson Anna , Kotevska Marija , Hanson Carsten Gram , Haakensen Vilde Drageset , Helland Åslaug , Tamborero David , Johansson Henrik J. , Branca Rui M. , Planck Maria , Staaf Johan , Orre Lukas M.
Published: November 2021

The associated publication reports proteogenomic analysis of non-small cell lung cancer, where we identified molecular subtypes with distinct immune evasion mechanisms and therapeutic targets, and validated our classification method in separate clinical cohorts. This protocol describes the sample preparation and mass spectrometry (MS)-based in-depth and rapid proteomic analyses of tumor and biopsy samples. We deployed single-pot solid-phase-enhanced sample preparation (SP3). For the in-depth analysis, we used TMT labeling, followed by high-resolution isoelectric focusing (HiRIEF) prefractionation and LC-MS with data-dependent acquisition (DDA). The reported protocol achieved analytical depth of close to 14,000 quantified proteins and almost 10,000 across the entire cohort of 141 samples. The rapid analysis was label-free, based on LC-MS with data-independent acquisition (DIA). The median number of identified proteins was 3,967 and 3,552 in two independent cohorts of tumor samples (n = 141 and 208, respectively), and 2,494 in another cohort of biopsy material (n = 84).
The Gaming Problem: A Latent Class Analysis of DSM-5 Criteria For Internet Gaming Disorder In A Non-Clinical Sample
Authors: Raybould Jodie N. , Watling Dylan C. , Larkin Michael M. , Tunney Richard J.
Published: November 2021

Background: We aimed to test whether suggested DSM-5 criteria for Internet Gaming Disorder (IGD) share a similar latent structure to formally recognised addiction. Methods: To do this we used latent class analysis on a dichotomous measure of IGD. The data was collected from a convenient general population sample (500) and a targeted gaming forum sample (236). Results: We found a four or six-class model to be most appropriate, ranging from ‘casual/non-gamer’ to ‘potentially disordered’ with increasing symptom severity. The majority of ‘potentially disordered’ gamers (5+ criteria) were found to be 18-30 years old, and no ‘potentially disordered’ gamers were over 42. Conclusion: The results suggest that gaming may share a similar latent structure to established addictions, with adolescents and young adults being more at risk. Studies replicating these results would be beneficial, with further emphasis on a critical evaluation of the criteria and symptom cut-off point.