bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of cardiovascular comorbidity in cancer patients and analysis of potential risk factors for cardiovascular complications of checkpoint inhibitor therapy
Authors: Kushnareva E. A. , Shuginova T. N.
Published: January 2022

Aim. To analyze the spectrum of cancer types and baseline cardiovascular comorbidity in patients receiving checkpoint inhibitor therapy.

Material and methods. We performed retrospective analysis of case records of 112 cancer patients (55 men and 57 women) who received checkpoint inhibitor therapy in St. Petersburg hospitals. We analyzed primary tumor localizations, received immunotherapy and the initial comorbid conditions in patients.

Results. The mean age of patients at the time of anticancer therapy initiation was 59,7±12,1 years for men, 57,7±14,1 years for women (p=0,249). The most common indications for immunotherapy were the following localizations: melanoma (34,8%), lungs (21,4%) and urinary system (12,5%). Among women who received checkpoint inhibitors, the lung and gynecologic cancer had the same prevalence (17,5%). The vast majority of patients (85,7%) received antiPD-1 agents, while the anti-CTLA4+anti-PD-1 combination was received by only 8,6% of patients, anti-PD-L1 monotherapy — 5,7%. Before anticancer therapy initiation, 69,6% of patients had prior CVD and/or risk factors. There were following most common comorbid conditions: hypertension — 58,9%, coronary artery disease — 36,6%, heart failure — 24,1%. At the same time, men in comparison with women were more likely to have prior stroke (12,7% vs 1,75%, respectively, p=0,024). There were no other significant sex differences between the incidence of cardiovascular diseases.

Conclusion. Based on current publications describing potential risk factors for cardiovascular complications of cancer immunotherapy with checkpoint inhibitors, among the patients included in this study, 87,5% of patients can be attributed to the high-risk group.
Optimization of blood pressure control, organ protection and metabolic disorders using a fixed-dose combination of lisinopril+amlodipine+rosuvastatin in hypertensive patients after COVID-19
Authors: Nedogoda S. V. , Ledyaeva A. A. , Chumachek E. V. , Tsoma V. V. , Salasyuk A. S. , Lutova V. O. , Popova E. A. , Vlasov D. S. , Bychkova O. I. , Labaznikova V. A. , Evdokimov K. S.
Published: January 2022

Aim. To evaluate the potential of a fixed-dose combination of lisinopril+amlodipine+rosuvastatin (Equamer®) in achieving additional vascular protection in patients with hypertension and high pulse wave velocity (PWV) after severe and very severe coronavirus disease 2019 (COVID-19), complicated by bilateral multisegmental viral pneumonia, with the use of biological therapy, who had not previously received combination antihypertensive therapy.

Material and methods. This 12-week open-label observational study included 30 patients with or without antihypertensive therapy. The patients underwent 24-hour blood pressure monitoring, applanation tonometry (determination of the augmentation index (AI) and central blood pressure (CBP)), PWV measurement, blood laboratory tests (lipid profile, fasting glucose, C-reactive protein, complete blood count, ferritin, fibrinogen, D-dimer, alanine aminotransferase, aspartate aminotransferase, creatinine, uric acid) before and after switch to a fixed-dose combination of lisinopril+amlodipine+rosuvastatin.

Results. At baseline, the patients had an increase in office blood pressure (BP) up to 152,6/89,1 mm Hg. After prescribing a fixed-dose combination of lisinopril+amlodipine+rosuvastatin, there was a decrease in systolic blood pressure (SBP) by 15,8% and diastolic blood pressure (DBP) by 12,2%. According to 24-hour blood pressure monitoring, the decrease in SBP was 15%, DBP — by 9%, PWV — by 23,8%, AI — by 9%, CBP — by 12,4% (p<0,05 for all compared to baseline values). Vascular age (VA) was initially increased to 41,9 years with a chronological age of 35,03 years. After the end of therapy, there was a significant decrease in VA to 36,5 years, low-density lipoproteins by 46,8%, triglycerides by 16,8% and an increase in high-density lipoproteins by 10,7% (p<0,05 for all compared to baseline values). In addition, the levels of C-reactive protein, fibrinogen, D-dimer, glucose, and uric acid significantly decreased.

Conclusion. The fixed-dosed combination of lisinopril+amlodipine+rosuvastatin provides better blood pressure control, improved vascular elasticity parameters (AI, PWV, CBP, decrease in VA), and also improves lipid and carbohydrate metabolism, reduces inflammation in patients with hypertension and hyperlipidemia after severe COVID-19.
Antithrombotic therapy for atrial fibrillation and comorbidities — how to choose the optimal solution?
Authors: Schlyakhto E V , Baranova E I , Ionin V A
Published: January 2022

The review discusses the problem of anticoagulant therapy for the prevention of stroke and systemic embolism in patients with atrial fibrillation and comorbidities (hypertension, heart defects, including after heart valve surgery, coronary artery disease, diabetes mellitus, chronic kidney disease, gastrointestinal diseases, anemia, cancer), as well as with a high risk of emergency operations and injuries.
Evaluation of the effect of the use of the drug ticagrelor in patients with acute coronary syndrome on achieving the target indicator “reduction of mortality from diseases of the circulatory system” in 2022-2024
Authors: Zhuravleva M. V. , Zyryanov S. K. , Paleev F. N. , Yakovlev A. N. , Marin T. V. , Gagarina Yu. V.
Published: January 2022

Aim. To evaluate the effect of the use of the double antiplatelet therapy (DAT) with ticagrelor compared to DAT with clopidogrel and antithrombotic therapy with acetyl salicylic acid (ASA) in patients with acute coronary syndrome and patients with high coronary risk on the target indicator (CP) of the state program (GP) “Development of Healthcare” and the federal project “Fight against cardiovascular diseases” — reducing mortality from diseases of the circulatory system (BSC).

Material and methods. All adult Russian patients with a diagnosis of ACS eligible for DAT were considered as the target population; in the second and third years, only patients with high coronary risk continued treatment. The calculation of the number of deaths that can be prevented using DAT ticagrelor 90 mg + ASA vs DAT of clopidogrel + ASA within 1st year from the date of diagnosis was based on the clinical efficacy data of the PLATO study. The number of deaths that can be prevented with the use of DAT ticagrelor 60 mg + ASA — instead of ASA monotherapy patients with a history of myocardial infarction was made based in the clinical efficacy results of the PEGASUS study. It was calculated what proportion of the target indicators could be achieved in 2022-24 years by using DAT with ticagrelor instead of clopidogrel or ASA monotherapy.

Results. The use of DAT with ticagrelor vs DAT with clopidogrel or ASA for the treatment of patients with ACS will prevent additional 5389, 5704 and 6012 deaths in 2022-2024, that will ensure the implementation of the CP “reduction of mortality from BSC” GP “Development of healthcare” in the Russian Federation by 36,9%, 26,0% and 20,6% respectively.

Conclusion. The use of DAT with ticagrelor for the treatment of patients with acute coronary syndrome ensure the implementation of the CP “reduction of mortality from BSC” GP “Development of healthcare” in the Russian Federation in 2024 by 20,6%.
Yiga Kaka (Cock Diagnosis)
Authors: Hamadama Aboubakar
Published: January 2022

In a small village in Northern Cameroon;  lives a respected Mboum head of the family with his many children.  The latter practices the Yiga kaka or Cockrel diagnosis where he earns his living by making the diagnosis and curing the sick through a cockrel.  This practice allows the Yiga kaka practitioner to identify what the patient is suffering from and provide care.  In this socioculture, only the initiated practitioner mastering the codes and the necessary knowledge can exercise this profession.  Despite the influence of modernity, Alim Sardi strives to perpetuate this practice.
Awoudou Ways of Seeing
Authors: Tezore Amandine
Published: January 2022

Les attaques de Boko Haram ont poussées plusieurs habitants des zones frontalières du Cameroun et du Nigeria à désertés leurs villages natal. C’est ainsi que toute la famille D’Awoudou fut décimée pendant les attaques de Boko Haram à Kolofata en 2016. Il eu la vie sauve grâce au voyage effectué ce jour pour l’achat de ses marchandises. Ainsi, cette nuit Boko Haram ôta sa dignité, sa famille, son autonomie financière et au delà de toute expérience, sa vue. « Awoudou ways of seeing » est un film sur la vie quotidienne d’Awoudou dans le camp de Zamai, Mayo Tsanaga, Cameroun. Il révèle son combat continu pour sa survie malgré les différents dilemmes. Son enthousiasme pour la survie va au delà de son handicape. Il a su créer des relations qui le lient à la population. Créant ainsi une lueur d’espoir, de joie et des épaules sur qui comptés. Malheureusement, l’appartenance à un autre groupe ethnique et religieux ne facilite pas son admission dans le camp.
When a River Becomes a Border
Authors: Layio Robi
Published: January 2022

Blangoua subdivision is the main Cameroonian window on Lake Chad. The Chari river which flows into the lake at the top of this town determines the border with Chad. The socio-cultural and economic proximity maintained by the population residing around the riverbank makes a border obsolete and unrealistic. People go freely and forth, and take advantage of these socio-ethnic corridors to sneak between the two nationalities in order to seize the opportunities presented to them. Waldiga, as many others in this region has a life on both sides. He navigates this reality in his daily life as a university student in Chad.
Married at 13, 13 Years Ago
Authors: Bako Moustapha
Published: January 2022

Synopsis (English) : 

When Ammiya was 13 years old, while in her 6th year at school, her parents sent her to marriage without her consent. As is customary in the Fulani and Muslim communities in Cameroon, no one tried to stop this marriage. Ammiya was hindered in continue her education, and to herself choose her husband. 13 years after her wedding, now divorced, she looks back and tell her story.

 

Synopsis  (French):

A 13 ans, ses parents l’envoient en mariage sans son consentement, alors qu’elle préparait le concours d’entrée en 6e et le CEPE. Comme de coutume dans la communauté peule et musulmane, aucune voix ne s’est levée pour empêcher ce mariage afin que l’adolescente Ammiya continue ses études, choisir son mari et le moment de se marier plus tard. 13 ans après son mariage, elle nous fait le bilan de ses 13 ans de mariage.
Public expenditure composition and fiscal decentralization in Brazilian local governments: an analysis through unconditional quantile regression with longitudinal data
Authors: Sousa Kleber Morais de , Monte Paulo Aguiar do
Published: January 2022

Abstract This paper investigates the effect of increasing fiscal decentralization on the composition of public expenditures of Brazilian local governments. The research is innovative, demonstrating that the heterogeneity of expenditure scale influences the correlation between fiscal decentralization and public expenditure of local governments. The sample consisted of unbalanced panel data of 5,565 municipalities for 17 years from 2000 to 2016. The analysis used unconditional quantile regression with panel data. The main findings were: (i) fiscal decentralization affects public expenditure in Brazilian local governments. However, this effect depends on local expenditure scale and fiscal decentralization strategy. For example, the median coefficient was negative in personnel expenditures, and the effect was positive for the third quartile of local governments, when fiscal decentralization was measured by the tax revenue over total revenue. On the other hand, the effects were also positive for median and third quartile regarding intergovernmental transfers per capita like proxy of fiscal decentralization; (ii) the measures (proxies) of fiscal decentralization are correlated with the composition of public expenditure; (iii) in median terms, fiscal decentralization has greater effects on investment expenditures than on current and personnel expenditures; and (iv) in median terms, the tax revenue participation promotes an increase in administrative and planning expenditures instead of expenditures in social functions. Fiscal decentralization measured by intergovernmental transfer per capita has more positive effects on social functions than on legislative and administrative functions.
Corrupção na educação superior pública? Estudo das Ifes de Minas Gerais
Authors: Oliveira Jamile Camargos de , Cruz Marcus Vinicius Gonçalves da
Published: January 2022

Resumo A corrupção na administração pública brasileira vem adquirindo maior centralidade graças aos sucessivos escândalos desvendados no país. As instituições públicas federais de ensino superior (Ifes) não passaram incólumes por esse contexto, chamando a atenção por se tratar de organizações voltadas à promoção da formação intelectual e cidadã. Este artigo analisa de que forma o ambiente organizacional se configura para o combate à corrupção por meio de um estudo de caso nas 17 Ifes de Minas Gerais. Para isso, verificam-se as características relacionadas com a corrupção em processos disciplinares administrativos (PADs), instaurados de 2015 a 2019, e entrevistam-se servidores que participavam da condução desses processos. A despeito de a maioria dos entrevistados não ter uma percepção clara do fenômeno da corrupção nas Ifes, os achados da pesquisa indicam que os principais fatores do ambiente organizacional referentes à integridade que contribuem para o combate à corrupção correspondem aos canais para manifestação de denúncia, aos mecanismos de controle externo e interno, aos instrumentos de promoção da ética e às regras de conduta, transparência e acesso à informação. Em termos de estrutura, constata-se que o corporativismo é o principal empecilho do ambiente organizacional no combate à corrupção. Para isso, sugere-se o desenvolvimento de pesquisas futuras voltadas a verificar a institucionalização das medidas da integridade nas Ifes como estratégia de combate à corrupção.
Uso não prescrito de metilfenidato por estudantes de uma universidade brasileira: fatores associados, conhecimentos, motivações e percepções
Authors: Rodrigues Laís de Aquino , Viana Nájila Aélida Oliveira , Belo Vinícius Silva , Gama Carlos Alberto Pegolo da , Guimarães Denise Alves
Published: January 2022

Resumo Introdução O metilfenidato, utilizado especialmente para tratar o Transtorno do Déficit de Atenção e Hiperatividade tem conquistado universitários que buscam melhorar o desempenho cognitivo. Objetivo Investigar conhecimentos, motivações, percepções e perfil de uso não prescrito desse medicamento por estudantes de uma Universidade Federal de Minas Gerais. Método Aplicação de questionário estruturado a 696 estudantes de Bioquímica, Enfermagem, Farmácia e Medicina, e análise descritiva e dos fatores associados ao uso, por meio de modelos de regressão logística. Resultados: Dos participantes, 96,7% afirmaram conhecer o medicamento e desses, 4,3% o utilizam/utilizavam por motivos não prescritos. O principal motivo de uso era o melhoramento cognitivo, e a universidade foi o principal local de início de uso. A maior parte dos usuários percebeu aumento na concentração e 50% relatou ocorrência de efeitos indesejados. Houve maior chance de uso não prescrito entre homens, maiores de 21 anos, envolvidos em atividades extracurriculares e menor chance de uso entre estudantes de Enfermagem. Conclusão A análise de diferentes aspectos relacionados com o uso não prescrito do metilfenidato propicia um melhor entendimento das situações vivenciadas entre universitários e aponta os riscos à saúde relacionados à busca por melhores desempenhos acadêmicos e estratégias para lidar com sobrecarga de atividades.
Revascularización endovascular compleja multinivel y multivaso a través de un bypass fémoro-poplíteo ocluído en paciente con isquemia crónica con amenaza para las extremidades inferiores
Authors: Arins Marcel Voos Budal , Alvarez Antenor
Published: January 2022

Resumen La isquemia crónica con amenaza para las extremidades inferiores (ICAEI) representa el estadio final de la enfermedad arterial periférica, un problema de prevalencia creciente que conlleva el aumento de los costos de salud en todo el mundo. La ICAEI es una enfermedad con elevada morbilidad, generando mortalidad significativa, pérdida de miembros, dolor y disminución de la calidad de vida. La principal causa de amputaciones no-traumáticas de miembros inferiores está relacionada a la diabetes y a la ICAEI. Entre un 2% y 3% de los pacientes con enfermedad arterial periférica se presentan con un caso grave de ICAEI, condición que se correlaciona con enfermedad arterial multinivel y multiarterial, calcificación y oclusiones totales crónicas. Se describieron varias estrategias técnicas para cruzar con éxito largas oclusiones en segmentos arteriales. Se puede realizar la recanalización utilizando técnicas endoluminales, subintimales y retrógradas. Relatamos un caso de revascularización endovascular compleja multinivel y multiarterial a través de un bypass fémoro-poplíteo en una paciente con ICAEI.
Resolvendo numericamente equações diferenciais fracionárias
Authors: Mendonça A. K. F. , Evangelista T. S. , Rispoli V. C. , Amorim R. G. G.
Published: January 2022

Apresentamos neste trabalho uma breve revisão sobre o cálculo fracionário e também o método de Adam-Bashforth fracionário para solução de equações diferenciais fracionárias. O método de Adam-Bashforth fracionário é devido a Diethelm et al. [1] e caracteriza-se pela sua eficiência, já que considera os efeitos de memória das derivadas fracionárias. A apresentação do tema é realizada de forma pedagógica, proporcionando a compreensão daqueles que são incipientes no assunto. Nesse contexto, exemplos são apresentados e algumas aplicações são discutidas.
Estratégia em destaque: duas décadas de produção científica do evento 3Es à luz da análise de redes sociais
Authors: Ribeiro Henrique César Melo
Published: January 2022

RESUMO Este estudo investigou o perfil e as características da produção científica divulgada no Evento 3Es durante as Edições de 2003 a 2017.Utilizou-se as técnicas bibliométricas e, predominantemente, a sociométrica enfocando as redes de 1 e 2 modos, em 929 estudos identificados. Nas redes one-mode, constataram-se redes esparsas e alta centralidade de grau e de intermediação nas duas décadas investigadas. Na rede social das instituições, ficaram em evidência USP e FGV (SP). Tendo em consideração as redes de coautoria, à luz das centralidades de grau e de intermediação nas duas décadas de estudo no 3Es, destacaram-se os pesquisadores Carlos Ricardo Rossetto, Clóvis L. Machado-da-Silva e Manuel Portugal Ferreira. No que tange a rede two-mode que enfoca os autores e os temas em conjunto neste trabalho, vislumbram-se os temas com maior número de autores vinculados a estes, ou seja, estudiosos que buscaram publicar sobre estes assuntos durante as duas décadas do evento em investigação. As temáticas foram: visão baseada em recursos, formulação de estratégia, redes inter e organizacionais, desempenho organizacional, internacionalização, empreendedorismo e inovação.
Transparência ambiental: da disponibilidade ao acesso à informação ambiental
Authors: Guerreiro Irene Costa Freitas , Vasconcellos Sobrinho Mário , Condurú Marise Teles
Published: January 2022

RESUMO Analisa a disponibilidade e o acesso de dados e informações ambientais governamentais para promoção da transparência ambiental e apresentação de elementos capazes de subsidiar o planejamento da gestão ambiental em nível municipal. Metodologicamente, numa abordagem qualitativa, tomou como objeto de estudo o Portal do Ministério do Meio Ambiente - MMA, bem como, para contraponto, o exame de potencialidades e limites do acesso às informações ambientais deste portal pelos gestores ambientais de 13 municípios localizados em diferentes regiões do Estado do Pará e níveis de autonomia e organização institucional para gestão ambiental. Esta análise revelou que o MMA apresenta limitações para transparência ambiental, permitindo duas conclusões: uma de ordem teórico-abstrata, em que a disponibilidade de informações não significa transparência e que critérios precisam ser considerados; e outro de ordem empírica, em que considerar as especificidades dos contextos subnacionais impõe ao MMA tomar como ponto de partida a Comissão Tripartite Nacional (CTN) com a finalidade de reunir os entes federados (governo federal, estados, Distrito Federal e municípios) e por meio de diálogos promover uma gestão compartilhada e descentralizada entre União, estados e municípios, e fortalecer a estrutura do Sisnama.
La experiencia vivida de la emergencia obstétrica: un estudio fenomenológico con mujeres mexicanas
Authors: Rangel-Flores Yesica Yolanda , Rincón-Zúñiga Diana Topacio , Hernández-Ibarra Luis Eduardo
Published: January 2022

Resumen Este estudio pretende profundizar en la experiencia vivida por mujeres mexicanas en la emergencia obstétrica. Para ello, se realizó un estudio cualitativo-fenomenológico por medio de entrevistas en profundidad a 15 mujeres sobrevivientes de esta experiencia que se realizaron en el periodo de enero a septiembre de 2017. La información se procesó mediante análisis fenomenológico del discurso, y para su interpretación se organizó en las cuatro dimensiones de la fenomenología de la percepción: cuerpo, tiempo, espacio y relacionabilidad. Las informantes percibieron la complicación de forma temprana, sin embargo, postergaron la atención institucional hasta que se hicieron presentes signos objetivos de complicación; la llegada puntual a los servicios de salud no implicó, desde su percepción, la certeza de manejo oportuno y adecuado, además se reportó un insuficiente apoyo de las redes formales e informales para el traslado y la atención especializada. Es necesario que sociedad y gobierno articulen estrategias que empoderen a las mujeres para la atención a las situaciones de emergencia obstétrica, acciones que promuevan su autocuidado pero garanticen también el apoyo pronto y expedito de sus redes y una atención profesional de calidad.
O papel da Santa Casa no sistema público de saúde brasileiro: o levantamento histórico de uma instituição filantrópica
Authors: Oliveira André Luiz Mendes , Sacomano Neto Mário , Donadone Júlio César
Published: January 2022

Resumo O artigo1 tem por objetivo analisar a evolução da interação entre Santas Casas e o Sistema de Saúde Público brasileiro por meio do levantamento histórico da Santa Casa de Mogi Mirim. Os procedimentos metodológicos foram de abordagem qualitativa e basearam-se em uma coleta de dados por pesquisa documental do levantamento histórico da Santa Casa em questão e do histórico dos principais marcos do sistema de saúde brasileiro. Os dados obtidos foram analisados para identificar o nível de interação entre a Santa Casa e a assistência hospitalar do sistema de saúde em vigor. O resultado desta análise histórico-comparativa demonstrou a intensificação da relação entre a Santa Casa e o sistema público de saúde, partindo de uma interação nula no início do século XIX que se transforma em uma codependência cercada de disputas e com limites muitos tênues no início do século XXI.
Sobre descrições, retificações e objetividade científica: reflexões metodológicas a partir de uma pesquisa sobre condutas sexuais e HIV/aids entre homens com práticas homossexuais
Authors: Rios Luís Felipe , Adrião Karla Galvão
Published: January 2022

Resumo Este ensaio reflete sobre a positividade de conhecimentos produzidos por abordagens etnográficas, a partir da discussão dos meandros de uma pesquisa sobre homens que se relacionam sexualmente com outros homens e vulnerabilidade ao HIV/aids. Propõe como falsa a oposição entre metodologias explicativas e compreensivas, uma vez que ambos os princípios estão presentes, em maior ou menor grau, em todas as investigações em ciências humanas e sociais. Nessa linha, põe em xeque critérios de cientificidade do “senso comum científico” que fazem o uso da matemática como o demarcador. Exemplifica como a descrição crítica do próprio ato de pesquisar e das retificações sobre os obstáculos ao conhecimento, identificados no próprio caminho, conferem objetividade aos conhecimentos produzidos. O diferencial etnográfico em relação a outras abordagens de ênfase compreensiva é a explicitação da própria experiência dos pesquisadores no campo como recurso crítico e analítico.
Calcareous seaweed flour in the diet of Japanese quails and its effects on egg conservation
Authors: SPANIVELLO Gabrielly Ribeiro , VALENTIM Jean kaique , GARCIA Rodrigo Garófallo , BURBARELLI Maria Fernanda de Castro , PRZYBULINSKI Bruna Barreto , KOMIYAMA Claudia Marie , EBERHART Bruna de Souza , CASTILHO Vivian Aparecida Rios de
Published: January 2022

ABSTRACT The aim of this study is to evaluate the influence of including levels of calcareous seaweed flour in replacement for calcite limestone on the diet under egg conservation at different storage periods. 140 Japanese quails were used in a completely randomized experiment consisting of a 4x4 factorial design. The factorial design was four inclusions of calcareous seaweed (0%, 10%, 20%, and 30%) and four storage periods (zero, seven, 14, and 21 days) with ten replications of three eggs each. The egg quality variables were evaluated. Data were subjected to analysis of variance using Tukey test and polynomial regression at a 5% significance level. There was no interaction effect between the factor's storage time and inclusion of calcareous seaweed (p>0.05). There was an increasing linear effect on shell weight and thickness in relation to inclusion levels of calcareous seaweed. There was an individual effect of egg storage time (p>0.05) on egg weight, yolk color, albumen and yolk height, yolk weight and percentage, albumen, yolk index, yolk diameter, specific gravity, and Haugh unit. The inclusion of up to 30% of calcareous seaweed in replacement for calcite limestone in the diet of Japanese quails improves the weight and thickness of eggshells but does not influence the conservation of the eggs up to 21 days of storage.
A NATUREZA DO CONHECIMENTO MATEMÁTICA E A DISCIPLINA DE ANÁLISE REAL: BREVES CONSIDERAÇÕES A PARTIR DE UMA REVISÃO SISTEMÁTICA DE LITERATURA
Authors: Lacerda Greice
Published: January 2022

Com esse ensaio proponho discutir as seguintes inquietações: quais concepções de conhecimento matemático influenciaram o desenvolvimento da disciplina de Análise Real? Essas concepções ainda influenciam seu ensino ou outras formas de pensar o conhecimento matemático fazem-se presentes em seu ensino na licenciatura em matemática? E como o objetivo geral de compreender a relação entre as principais concepções filosóficas sobre a natureza do conhecimento matemático, o surgimento da Análise real e o seu ensino na licenciatura em matemática na atualidade, apresento brevemente as principais concepções sobre a natureza do conhecimento matemático; destaco suscintamente algumas considerações sobre o desenvolvimento da Análise Real; e descrevo os procedimentos metodológicos utilizados para buscar indícios para identificar concepções ou tendencias que influenciam o ensino da Analise nos cursos de licenciatura na atualidade. Logo, a partir de uma pesquisa qualitativa bibliográfica, inspirada na metodologia de revisão sistemática de literatura e com o auxílio do software IRaMuTeq, espero enriquecer meu conhecimento das concepções sobre a natureza do conhecimento matemático e sobre o desenvolvimento da a Análise Real e contribuir com as discussões sobre o tema no campo da Educação Matemática.
Stability assessments of a triple-tunnel portal with numerical analysis (south of Turkey)
Authors: Can Asli , Baskose Yasin , Gokceoglu Candan
Published: January 2022

The Bahce–Nurdag tunnel, which is the longest railway tunnel in Turkey with approximately 10 km was planned as two tubes. During the excavation of the second tube starting from the Nurdag portal, the tunnel-boring machine (TBM) jammed at 1267 m of the excavation. The second tube was abandoned due to TBM jamming, and it was decided to build a third tube. For this construction, additional portal and tunnel excavations were needed. These excavations resulted in additional stresses. Moreover, the project was constructed in a highly seismically active region. For this purpose, the tunnel portal section was investigated numerically by finite-element analysis. Considering the results obtained from the three-dimensional (3D) numerical analysis, the existing portal was enlarged and excavation of the third tube was started. Currently, the portal construction was successfully completed, and the third tube was excavated for approximately 2200 m with the TBM. It was concluded that the suggested methodology with the excavation and support systems was found satisfactory when the analysis results were compared with in situ conditions. This study suggests that multiple tunnels and large portals to be constructed in highly seismically active regions be simulated by 3D numerical analysis for successful construction.
Review - Test
Authors: Ward Robert
Published: January 2022

Algren
Az elektromos szálhúzás technikájának bemutatása
Authors: Juhász Ákos György
Published: January 2022

The history of the electrospinning technique started a couple of centuries ago. The technique has evolved continuously and found more and more applications. As science has progressed, the physical phenomena involved in the formation of fibres have been more and more precisely defined, thus creating equipment to meet different needs. Nowadays, not only microfibres but also nanofibres can be created while using this method, making it possible to create materials suitable also for biomedical applications. The growing interest is reflected in the increasing number of publications too. This brief review concerns the main milestones of the history of electrical fibre drawing and the various fibre formation methods used today.
A transzkatéteres aorta billentyű implantáció múltja és jelene
Authors: Dékány Gábor
Published: January 2022

Calcified aortic stenosis is the most common valve disease in the developed world. Transcatheter aortic valve implantation (TAVI) represents an available treatment option in patients with severe aortic stenosis who were not suitable or at extremely high risk for traditional surgical valve replacement. The present study reviews the most important historical milestones and trials of TAVI as it is used in our days. We discuss the present role of the procedure from indication to implantation.
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Published: January 2022

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Neighborhood Planning for a Divided City: The Case of Beirut
Authors: Aouad David
Published: January 2022

This article discusses planning within Municipal Beirut, Lebanon, while focusing on the specific context of divided cities and societies, proposing a series of recommendations based on socio-economic and political science and planning theory to understand such contexts. It explores the case of Municipal Beirut that has undergone a devastating blast on August 4th, 2020, and left thousands of households in critical condition by leaving an already shattered sectarian city/society with an unforeseen planning future. By examining successful examples or frameworks in other cities and similar-context cities in history with urban/social shocks, evaluating current planning initiatives, and analyzing the case study of the recent Beirut Urban Declaration report, this article investigates neighborhood planning as a flexible framework that one must undertake to provide the divided city of Beirut a healthy and sustainable development. It argues that difference and diversity are a noteworthy feature of the city of Beirut and its society and should hence be incorporated in any planning approach even if the consequences on the ground may differ. Considering that planning could change the spatial, socio-economic, and political dimensions of a defined urban space, this article explores which of these dimensions can be used to intensify or lessen contestations over space in Beirut under the current sectarian culture reflected in both social and spatial realms. In the wake of the blast and amid all these divisions, this article will show that neighborhood planning stands out as a flexible and sustainable solution. By establishing a spatially targeted program, introducing innovative tools for neighborhood planning and management, and initiating a small-scale governance structure, neighborhood planning will create an intermediate level between the municipality, citizens, and other local actors, enhancing its social capital and leading eventually to an undivided planning strategy at a national and city scale.
Economic burden of chronic viral hepatitis C
Authors: Yakhina R. A. , Lakman I. A. , Valishin D. A. , Bakhitova R. Kh.
Published: January 2022

Background.The spread of chronic viral hepatitis C (CVHC) among the population entails significant costs for society, both direct, associated with the treatment of such patients, and indirect, associated with the shortfall in fiscal payments to the budget, due to the disability of this category of patients. Therefore, an important task remains to assess the global economic burden of the disease, taking into account the pathological conditions of the human body associated with it.Objective:to systematize studies of published sources devoted to assessing the global economic burden of chronic viral hepatitis C.Material and methods.A feature of the proposed review design is paying attention not only to the objects of assessment under study, but also to the instrumental (including mathematical) means of scenario assessment of the global burden. The study analyzed 29 sources published between 2014 and 2020 and dedicated to assessing and forecasting the global economic burden of CVHC both in individual countries and continents as a whole, and in individual regions of countries. The main criterion for the selection of studies was the availability of an estimate of the global burden of CVHC, taking into account the use of direct antiviral drugs for the treatment of hepatitis C. The search was conducted in PubMed/MEDLINE and eLibrary databases, and in the ResearchGate network.Results.Of the 29 analyzed sources, 40% of the works consider the burden for CVHC only of certain genotypes; in the overwhelming number of articles (80%), when assessing the burden, the distribution of patients by the degree of liver fibrosis is taken into account. In 50% of the studies reviewed, quality of life adjustment tools (QALY or DALY) were used to estimate the global economic burden. A third of the publications took into account both the direct costs of treating CVHC and indirect costs, including those associated with a shortfall in the contribution to the gross national product due to temporary or permanent disability of this category of patients.Conclusion.The analysis showed that interest in assessing the global burden of CVHC began to appear in recent years, when expensive directacting antivirals for the treatment appeared. This is explained by the emergence of a question about the cost of implementing a scenario in which by a certain year it will be possible to completely exclude the spread of the disease. The results of this work may be useful in conducting such studies, including the determining of their design and the use of modern mathematical modeling tools.
Evidence-Based Approach in Management: Evidence-Based Management and Policy
Authors: Semya G.V. , Stanilevsky V.V. , Gazaryan A.A. , Nekrasov A.S.
Published: January 2022

Objective. Review of the concepts of “evidence-based approach in management”, “evidence-based management”, and “evidence-based policy”. Systematization of factors that inhibit and contribute to the dissemination of evidence-based management practices in the social sphere. Identification of priority measures to support the development of an evidence-based approach in the management in the social sphere.Background. Executives in general, and also in the social sphere, are facing challenges of an increasing level of uncertainty, which brings difficulties to make reliable forecasts and make decisions with guaranteed results. At the same time, there is a systemic crisis of resources, requiring the choice of strategies and tactics that provide the highest level of performance. An additional challenge is the increasing amount of operations and the emerging need for managers to make quick management decisions. Against this background, the evidence-based approach acquires particular importance, based on the idea of the need to rely on the findings of research and expertise, providing managers with relevant data for choosing certain areas of action.Methodology. Literature review.Conclusions. The evidence-based approach in management is a range of practices with various severity of requirements, connected by the need for evidence-based and expert data for decision-making. Evidence-based management is a process of implementing an evidence-based approach within the framework of the activities of different level managers. Evidence-based policy is the implementation of evidence-based principles in making political decisions. Promotion of the evidence-based approach in management encounters several barriers such as assessment, used methodology, finance. However, some conditions can positively influence its promotion among practitioners: the involvement of senior managers, specialized training, the convergence of practitioners and researchers, and other factors. The funding of research and its accessibility remains critical.
CCT Analysis and Effectiveness in e-Business Environment
Authors: S Dr. Anasica
Published: January 2022

The priority of the business is to ensure that both the clients and staff working around the business are all safe. All the assault cases within the business will be treated with the seriousness they deserve. The rules and regulation of the business criminalizes any form of violence within the business premises. The installed security cameras will be ideal in monitoring the behavior and the conduct of all the individuals within the business. In case it is noted that someone is behaving contrary to the rules, the security team within the building needs to act fast to get such individual to the state authorities. The relationship between the staff should remain cordially, and all workers need to respect each other. The business management does not condone the use of violence against the staff members. Anybody found to use violence against a fellow staff will be interdicted and face the assault charges.
Business Security Design Improvement Using Digitization
Authors: Zellar Prof. Ivan
Published: January 2022

In this simulation study, the facilities were not crowded. The reading environment in these businesses was also observed to be promising in such a way that they were marked by good lighting, minimal noise, and adequate ventilation. Another physical aspect concerned the stock of books. In particular, the businesses displayed a state of variety whereby these books were arranged based on the broad and specific subjects to which they belonged. The use of technology was another dominant feature in the three businesses and this trend can be linked to the pressure towards keeping abreast with changing technologies and the evolution of business user demands in these institutions. Apart from the availability of books in physical form, sections of the copies were available in the soft copy and this feature was pronounced in the case of the high business center. The businesses were also different in terms of the overall physical sizes but this attribute could be attributed to the differences in the expected number of users. For example, the middle school and high school businesses were larger compared to the elementary business center visited but this outcome could be explained by the smaller number of business users in the selected elementary school. Hence, it can be inferred that the expected number of users dictates the overall and physical size of a business center.
In memory of Academician I. P. Merzheevsky
Authors: Bekhterev Vladimir M.
Published: January 2022

Today's meeting of the Psychiatric Society, in accordance with the decision of its Council, we dedicated to the memory of Academician IP Merzheevsky, who died on March 5 in Paris from a cerebral hemorrhage. Under the fresh impression of such a sad event, it is difficult to appreciate the full significance of the heavy loss that we experience along with the death of I.P. But it can be said with certainty that Russian psychiatry, in the person of I.P. The vast majority of Petersburg psychiatrists and psychiatrists in other cities, the society of psychiatrists in St. Petersburg lost in the person of I.P. lost in the face of I.P. the most handsome psychiatrist, who enjoyed great fame and the general love of his patients.
Photographic reading aloud
Authors: Osipov Viktor P.
Published: January 2022

The morbid disorder, which we characterize by the term photographic reading aloud, is so peculiar that although we have mentioned it in our work on catatonia, we nevertheless consider it proper to consider this disorder in more detail in a separate article; at a meeting of the Society of Neurologists and Psychiatrists at the Imperial Kazan University on October 22, 1907, we made a presentation on the aforementioned disorder and could exchange opinions with our comrades in the specialty about the origin of the painful phenomenon that interests us.

Here is the story of a patient who was under our supervision.
Prof. G Marinesco and I. Minea. About microscopic sympathetic hypospinal nodes. — Neurologisches Centralblatt. 1908 No. 4
Authors: Veselitsky I. A.
Published: January 2022

By chance, during the study of the spinal ganglia, the authors discovered in the neighborhood of the subganglionic part of the spinal nerves, (near the corresponding spinal ganglia), small sympathetic ganglia, inaccessible to the naked eye and visible only in microscopic sections. Some technical precautions are necessary to find these knots. Usually these nodules are located outward and downward from the corresponding spinal ganglia and never above them or in the intraarachnoid part of the spinal roots.
Prof. N. Oppenheim. To the doctrine of the periodicity of certain symptoms in nervous diseases. Neurologisches Centralblatt No. I—1908)
Authors: Veselitsky I. A.
Published: January 2022

The author draws attention to the well-known fact that nervous diseases of various types tend periodically and sometimes with remarkable regularity, at certain more or less intervals of time, to appear with particular intensity. This fact has been of interest to the author for several years, and he is trying to put it forward, to put it in line for development and discussion, without trying, on his part, to offer any theory or hypothesis for explanation.
Dr. Felix Mendel. Treatment with fibrolysin and its results. "New in Medicine". Nos. 1, 2, 3. 1908
Authors: Zhilin Ivan N.
Published: January 2022

Fibrolysin is a double compound of thiosinamine and salicylic sodium, easily soluble in water. The field of application of fibrolysin is diseases accompanied by the development of fibrous, interstitial tissue.
Sicard et Descomps. Failure of surgical treatment of Torticollis Mentale de Brissaud. (Nouvelle Iconographie de la Salpetriere. No. 6-1907)
Authors: Khudyakov A. I.
Published: January 2022

Strong man 44 y.o. after depressing family troubles, he received torticollis, which he could correct by pressing his left hand on the occipital region. According to prof. Brissaud "is an act of saving faith, because the will could never be sufficiently restrained to leave freedom for the muscles of the antagonists to be mutually conquered."
Letter to the editor
Authors: Rein F. A.
Published: January 2022

The Board of the Society of Russian Doctors in memory of N. I. Pirogov asks you to print the attached application with the draft charter of the permanent court of honor at the Pirogov Society.

The 10th Pirogov Congress of Doctors instructed the Board to "elect a commission, in which to include also comrades at will, to develop the issue of courts of honor and submit the draft for approval by the 11th Pirogov Congress."