bluuebunny/crossref_metadata_2025 huggingface dataset:
ЗАЩИТА АВТОРСКИХ ПРАВ НА ФОРМАТ ОНЛАЙН-ШОУ
Authors: ВАРТАНОВ Артем Сергеевич
Published: June 2024

В статье рассмотрена крайне актуальная в последние годы проблема защиты авторских прав на онлайн-шоу, или трансляций в сети интернет. Проведен сравнительный анализ информационного и авторского права, рассмотрено место онлайн-шоу в этих отраслях. Обосновыван правовой статус онлайн-шоу как аудиовизуального произведения. Проанализированы зарубежный опыт и судебная практика, в результате чего даны рекомендации по внесению изменений в часть четвертую ГК РФ.
Patient education about subclinical hypothyroidism in preconception and early pregnancy
Authors: Anastasia Navitski , Rebecca Joseph , Alexandria Riedel , Kaitlyn Kennedy , Christian Reinhardt , Larisa Gavrilova-Jordan
Published: June 2024

Introduction: The diagnosis and treatment of Subclinical Hypothyroidism (SCH) in preconception and early pregnancy has been an area of debate. The challenge of managing SCH further lies in often suboptimal patient understanding of the condition given its asymptomatic state. This study aimed to assess whether patient education materials could improve patient knowledge about SCH and encourage compliance with clinical management. Furthermore, we reviewed the current recommendations for the diagnosis and treatment of SCH in preconception and pregnancy. Methods: Patients who presented to the Reproductive Medicine and Infertility Clinic, Augusta University, Georgia, USA between July 2023 and February 2024, who were attempting to conceive or in early pregnancy, and who met the SCH diagnostic criteria were invited to participate in this prospective cohort study. The study participants completed a pre-education and demographic questionnaire, underwent a brief consultation with a provider who reviewed the SCH information sheet, and then completed the post-education questions. Paired Wilcoxon rank-sum tests of significance were used to evaluate the change in pre- and post-education scores. Results: Thirteen patients completed the survey. There was a range of pre-existing knowledge about SCH in our study population. Most patients acquired knowledge about SCH diagnosis (Q1: P = 0.013) during the counseling. Patient education improved their attitudes about the treatment of SCH with levothyroxine (Q3: P = 0.029). Conclusion: While the clinical guidelines on diagnosis and treatment of SCH in preconception and early pregnancy continue to evolve as more research becomes available, patient education can significantly improve their knowledge about the condition and encourage compliance with treatment if indicated.
JEAN JACQUES ROUSSEAU’NUN EĞİTİM ANLAYIŞINA GÖRE ÇOCUK GELİŞİMİNİN DEĞERLENDİRİLMESİ
Authors: Dağdelen Mücahit , Şeker Ömer Faruk
Published: June 2024

Düşünce tarihi içinde önemli bir kaldırım taşı ve potansiyel zemini temsil eden Aydınlanma Dönemi, kendinden sonraki dönemler için önemli bir projeksiyon görevi görür. Bu görevin işlevi halen günümüz için de devam etmektedir. Söz konusu önemin başat aktörü ve temsilcisi de eğitime önemli bir katkı yapan J. J. Rousseau’dur. Rousseau, “Emile” adlı kitabında çocuk eğitimini dönemine göre başka ve o zaman kadar bilinmeyen açılardan ele alarak değerlendirmiştir. Bu değerlendirme biçiminde çağın mevcut pozitivist eğitim sistemine önemli eleştiriler yöneltilmiştir. Döneminde kabul görmemiş ve çeşitli cephelerin hedefi olmuştur. Yaşadığı döneme göre özgün ve orijinal olan ve günümüzde de en çok referans gösterilen “Emile” de, “Doğa eğitimi”, ki, bu yaklaşım biçimi onun eğitim felsefesinin temellerini oluşturur, çocuklar için etkin bir öğrenme başlangıcı demektir. Ancak Rousseau eserinde çoğunlukla erkek çocuklarının eğitimine değinmiş, kız çocuklarının eğitimi ile ilgili kısıtlı sayılabilecek öneriler sunmuştur. Erkek çocukların başta doğacılık anlayışına göre şekillendirdiği eğitimle başlayıp, özerkliği kazanan bireyin zihinsel, ahlaki, cinsel ve dini gelişimlerini bu açıdan inceleyerek düşüncelerini yansıtmıştır. Kız çocuklarının da bu anlayışla büyüyen “Eş”e uyum sağlayacağı düşüncesi hakimdir. Çalışmalarında verilen örnekler ve sonradan yapılan araştırmalar neticesinde eleştirilen yanları olsa da döneminin etkili ve etkileyen filozofudur. Bu çalışmada Rousseau’nun eğitim anlayışı, çeşitli eğitim felsefeleri, çocuk gelişimine dair görüşleri ve katkısı incelenmiştir.
MODERNIST EXPERIMENTS AND NARRATIVE INNOVATIONS IN JAMES JOYCE’S NOVELS
Authors: Mikleadze Diana
Published: June 2024

The presented paper underscores the enduring relevance of Joyce's works within the scientific literary community. The work meticulously reviews, analyzes and evaluates James Joyce's innovative narrative technique in close connection with modernist literature. The relevance of the issue raised in the paper is confirmed, first of all, by the fact that Joyce's trace in modernist literature remains one of the main centers of scientific literary studies. The primary reason of this is the powerful influence of Joyce's work on literary evolution. Concrete examples are used to show the innovativeness of Joyce's work and the literary methods by which the author deviated from the established literary standards. The work delves into the themes of Joyce's works, which revolved around alienation, dislocation, disillusionment, and existential issues Each of these issues are discussed from the perspective of the era, on the basis of which it was determined that modernism was a kind of reaction to the socio-political and cultural events of the 20th century. The work generally tries to bring the very innovative linguistic experiments that made Joyce's modernist literature. Joyce's modernist works such as "Ulysses" or "A Portrait of the Artist as a Young Man" are full of radical departures from classical literary standards. His complex narrative techniques, including even stream-of-consciousness and linguistic experiments, continue to pose a significant challenge to the modern scientific community, whose research focuses on the limits of literary expression and the inherent possibilities in language.
Protocolo de coleta de amostras para eDNA metabarcoding usando filtros Sterivex - LGC PUC Minas v1
Authors: Antônio Mendes Gabriel , Costa Berger Guilherme , O Hilário Heron , Cardoso de Carvalho Daniel
Published: June 2024

O objetivo deste protocolo é orientar sobre a coleta de amostras de água para empregar a técnica de DNA ambiental (eDNA) metabarcoding. Nesta metodologia empregamos os filtros Sterivex, que permitem uma filtragem no local de coleta, com fácil manuseio, menor risco de contaminação e uma melhor preservação de DNA ambiental nas amostras. Este protocolo foi desenvolvido pelo Laboratório de Genética da Conservação - PUC Minas, e está em constante aprimoramento. Conheça nosso grupo e linhas de pesquisa: https://sites.google.com/view/lgcpucminas
Brain Tissue RNA Extraction -- University of Minnesota TMCs v1
Authors: A Bernlohr David , Martell Martinez Hector
Published: June 2024

RNA extraction protocol from snap frozen tissues and/or cell pellets adapted from PureLink RNA Mini Kit and PureLink with TRIzol Reagent protocols (attached). Protocol here used with neurological tissues prior to Bulk RNA sequencing.
La fortaleza de Guarros (Paterna del Río, Almería):
Authors: Rouco Collazo Jorge , Abellán Santisteban José , Martínez Carrillo Cristina , Martín Civantos José Mª
Published: June 2024

This paper aims to present the constructive evolution of the fortress of Guarros (Paterna del Río, Almería) and the discovery of a metallurgical production area. This fortification was occupied between the 8th and 13th centuries. This work analyses in detail the evolution of the fortress through building archaeology. It relates it to the mining possibilities of the surrounding territory to contextualise the metallurgical production area. The results show that this production is limited to the early medieval period and seems to correspond to the Late Antique and Early Medieval production models documented on the northern side of Sierra Nevada, with small workshops far from the extraction areas. This is an important advance in our knowledge of medieval mining and metallurgy on the southern face of Sierra Nevada, practically unknown until now.
El cerro de la Judería de Atienza: primera aproximación arqueológica
Authors: Mattei Luca , González Ballesteros José Ángel , Eiroa Jorge A. , García-Contreras Ruiz Guillermo , García García Marcos , Medina Cuesta Ana , Pluskowski Aleks G.
Published: June 2024

The archaeological excavations carried out in the medieval Jewish quarter of Atienza (Guadalajara) in 2022 constitute the first comprehensive approach to the archaeological site of the walled quarter in which this religious minority resided. Although there are numerous reports from written sources of the presence of an important Jewish community in Atienza during the late medieval centuries, until now there had only been a few superficial approaches to its archaeological remains. The planned archaeological excavation summarised here, carried out as part of a wider territorial study project, has documented a 13th and 14th century domestic context in the central sector of the Jewish quarter. The analysis of the exhumed structures and the archaeological materials found in context, especially ceramics and archaeozoology, allows us to establish relevant considerations regarding the processes of occupation and abandonment of the quarter and about the central question of the archaeological identification of the late medieval Jewish communities. The site is also an exceptional space for the collection of archaeobiological samples, whose potential for advancing the study of the relationship between these medieval communities and the natural environment has barely been glimpsed.
Direct Replication in Experimental Communication Science: A Conceptual and Practical Exploration
Authors: Vermeulen Ivar , Masur Philipp K. , Beukeboom Camiel J. , Johnson Benjamin K.
Published: June 2024

Replication is generally considered a keystone of the scientific enterprise. Unfortunately, in communication science, there is a lack of clarity on what a replication actually entails, and to what extent replicators may deviate from original studies. In order to support researchers in conducting, evaluating, and justifying the setup of replications of communication science experiments, we provide a taxonomy of replication types. We argue that researchers almost always need to adapt some elements of an original communication study to meaningfully replicate it. The extent to which deviations—ranging from mere updates to deliberate deviations and additions—are permissible, however, depends on the motivation behind conducting a replication study. We distinguish three basic motivations: verification of an original study’s findings, testing the generalizability of an original study (which we further differentiate into the generalizability of study outcomes vs. theoretical claims), and extending an original study beyond the original goals. We argue that these motivations dictate what types of deviations are permissible and thereby determine the type of replication (i.e., direct, modified, and conceptual). We end with concrete recommendations for replicators: to specify the motivation to conduct a replication study and clearly label and justify any deviations from the original study for all study elements. 
Are We Replicating Yet? Reproduction and Replication in Communication Research
Authors: Breuer Johannes , Haim Mario
Published: June 2024

The replication crisis has highlighted the importance of reproducibility and replicability in the social and behavioral sciences, including in communication research. While there have been some discussions of and studies on replications in communication research, the extent of this work is significantly lower than in psychology. The key reasons for this limitation are the differences between the disciplines in the topics commonly studied and in the methods and data commonly used in communication research. Communication research often investigates dynamic topics and uses methods (e.g., content analysis) and data types (e.g., media content and social media data) that are not used, or, at least, are much less frequently used, in other fields. These specific characteristics of communication research must be considered and require a more nuanced understanding of reproducibility and replicability. This thematic issue includes commentaries presenting different perspectives, as well as methodological and empirical work investigating the reproducibility and replicability of a wide range of communication research, including surveys, experiments, systematic literature reviews, and studies that involve social media or audio data. The articles in this issue acknowledge the diversity and unique features of communication research and present various ways of improving its reproducibility and replicability, as well as our understanding thereof.
Review of the II Annual Scientific and Practical Conference in hybrid format “Diagnosis, treatment, and legal aspects in care for patients with oncohematological and orphan diseases”
Authors: Shuvaev V. A.
Published: June 2024

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Alveolo-dental trauma: Epidemiological, clinical and therapeutic aspects at Centre Hospitalier Universitaire Yalgado Ouédraogo
Authors: Guiguimdé Wendpouiré Patrice Laurent , Jocelyne Garé Wendkuni Valérie , Patrice Bayala Jean , Désiré Kaboré Wendpouloumdé Aimé , Tarcissus Konsem
Published: June 2024

: TAD constitutes one of the most frequent and urgent reasons in the stomatology and maxillofacial surgery (S/CMF) department. This study aimed to contribute to improving the management of alveolar-dental trauma at CHU-YO.

This was a retrospective case series study, based on the clinical files of patients who underwent TAD and admitted to the S/CMF department of the CHU-YO during the period of study from July 1, 2022 to June 30, 2023. Data were collected from collection sheets and patient files during this period.

100 cases of TAD were collected in the S/CMF department of the CHU-YO. These TADs were relatively frequent. The age group of 15 to 30 years was the most affected (51%). Male predominance was clear (64%). ACRs were the greatest providers of alveolar-dental trauma (84%). Dislocations were predominant (51%) and the elective site was the upper jaw (61%). Medical treatment consisted mainly of antibiotics (100%), analgesics (97%), anti-inflammatories (71%) and topical uses of oral antiseptics (100%). The most commonly performed surgical treatment was soft tissue sutures. Restraints using Duclos arch ligatures were the subject of the majority of cases of orthopedic treatment (46%). Evolution was good in 84% of cases. Dental mobility (4%) and alveolitis (4%) dominated the table of complications.

: Reducing ACR, which involves significant road prevention, would undoubtedly contribute to reducing the incidence of alveolar-dental trauma. Strengthening the technical platform and interdisciplinary collaboration of the department of odontostomatology and maxillofacial surgery could improve patient care at the CHU-YO.
Odontogenic cysts in the maxillary sinus: A case series
Authors: Ashok Anakha , George Eldhose K , Steaphen Paul , Abraham Sumary
Published: June 2024

In this article, we present a series of three patients who reported to the department with different chief complaints. The patients underwent the necessary basic and advanced radiological investigations which showed presence of cysts along with impacted teeth in the maxillary sinus, following which all the patients were subjected to cyst enucleation under GA and the surgical specimens were sent for histopathological examination for definitive diagnosis.
Navigating neurofibroma: A clinical case report
Authors: Chakraborty Dipanwita , Ghatke Malashri N , Vibha Miriyala Satyashree , Tayi Shilpa Ravishankar
Published: June 2024

Spindle cell neoplasm is an unusual bimorphic malignant tumor that typically affects the upper aero-digestive tract mucosa but can potentially arise elsewhere in the body. A diverse range of benign and malignant tumors, including those with neural, fibroblastic, vascular, myofibroblastic, myogenic, and epithelial origins, are together referred to as soft tissue spindle cell neoplasms. The average age of occurrence is 51 years for men and 67 years for women, with a predominance of men. There is limited information in the literature about the symptoms of spindle cell neoplasms. These tumors typically have a polypoid form, with a high concentration of dysplastic spindle cell components. They are composed of surface epithelial alterations ranging from mild epithelial dysplasia to invasive carcinoma. The article provides insight into a case of neurofibromatous variant of spindle cell neoplasm.
Odontogenic myxoma: A dual affliction in maxilla and mandible - A case report
Authors: Agrawal Saloni Santosh , Parihar Ajay , Tosh Sujata , Yadav Nidhi
Published: June 2024

The odontogenic myxoma (OM) is a locally invasive benign odontogenic tumour of the jaws, thought to originate from the mesenchymal portion of the tooth germ. It commonly manifests in individuals during their second or third decade of life.

Females experience a higher frequency of occurrences compared to males, and there is a greater inclination for odontogenic myxoma to affect the mandible rather than the maxilla. In most cases, OM manifests as an asymptomatic swelling. Due to its non-capsulated and aggressive nature, there is a notable high recurrence rate reported.

Small myxomas are typically addressed through curettage, but it is crucial to conduct thorough follow-up examinations for a minimum of 5 years. The standard treatment for myxoma typically involves surgical resection.

Our article highlights two instances of odontogenic myxoma occurring in separate locations. The emphasis is on summarizing distinctive clinical and radiological behaviour of these lesions manifesting in the maxilla and mandible.
Oral melanoacanthoma: A new entity in 2022 WHO
Authors: Rawat Garima , Aiyer Hema Malini
Published: June 2024

: To highlight the occurrence of Melanoacanthoma in oral cavity.

Melanoacanthoma of the oral cavity is rare benign reactive pigmented lesion. It has been recently considered as a distinct entity in the World Health Organization (WHO) classification. Oral melanoacanthomas are reactive and not related to seborrheic keratosis unlike their cutaneous counterparts which are variant of pigmented seborrheic neoplastic in nature. These lesions are characterized by hyperplasia of dendritic melanocytes dispersed throughout an acanthotic epithelium with buccal mucosa being the most common location.

An 81-year-old female presented to us with complaint of blackish patch on hard palate. The patient underwent biopsy and the histopathological diagnosis of Melanoacanthoma was given.

To the best of our knowledge this is first such case of Melanoacanthoma on the hard palate in Indian subcontinent.

: Awareness about these lesions is important for apt diagnosis and preventing under diagnosis.
Family Lack of Awareness and Conflict Leads to Abuse and Exploitation at the Workplace
Authors: programme CLARISSA
Published: June 2024

The Adult Entertainment Sector (AES) is a relatively new and growing sector in Kathmandu, developing rapidly after international aid and trade relations led to the growth of a consumer economy and the development of a consumer culture. The AES employs women and girls in a context where alternative work opportunities are limited. The sector is included by CLARISSA as one of the worst forms of child labour (WFCL) due to the nature of forced labour, slavery, and commercial sexual exploitation of children inside the sector. During the CLARISSA life story analysis, many children from this area emphasised poor family relationships and the majority of children from this settlement are engaged in some sort of child labour. This is a report of the Action Research Group in this location, which covered two themes: (1) lack of awareness and family conflict leading to abuse and exploitation at the workplace, and (2) social norms around voices of children not being important in relation to family matters.
Розробка предметно-орієнтованих інноваційних програмних продуктів на основі систем штучного інтелекту
Authors: Стенін О. , Пасько В. , Лісовиченко О. , Польшакова О. , Солдатов В.
Published: June 2024

Відомо, що знання про об'єкт, що розробляється, в даному випадку інноваційному програмному продукті, визначають структуру системи управління його розробкою. Це справедливо системи управління розробкою більшості об'єктів різноїфізичної природи та його призначення. Однак програмні продукти мають важливу особливість: знання про них мають відносно велику динамічну складову, настільки велику, що її часто доводиться враховувати навіть у оперативному управлінні. Високий рівень обґрунтованості інноваційних рішень у процесі управління розробкою інноваційного програмного продукту може бути досягнутий без сильних когнітивних здібностей розробника стосовно програмного продукту. Це з еволюцією знань у предметної області. У статті пропонується інфологічна модель процесу управліннярозробкою інноваційного програмного продукту. Сутність запропонованого підходу у тому, що розробка інноваційного програмного продукту сприймається як інформаційний об'єкт, який змістовно і структурно змінюється у його створення. Запропоновано структуру інтелектуальної системи підтримки прийняття рішень, що дозволяє приймати інноваційні рішення на кожному етапі процесу розробки інноваційного програмного продукту.
Бібл. 19, іл. 7
Оперативне керування інженерними мережами міста на основі систем штучного інтелекту
Authors: Стенін О. , Пасько В. , Солдатова М. , Дроздович І.
Published: June 2024

Функціонування сучасного міста базується на комплексі різноманітних засобів забезпечення життєдіяльності громадян і роботи організацій, у тому числі міських інженерних мереж (МІС), які забезпечують централізоване постачання електроенергії, тепла, газу, води тощо. Різним аспектам діяльності МІС присвячено досить багато робіт. Проте перспективи інтелектуалізації управління МІС з урахуванням наявності та розвитку інформаційно-телекомунікаційних технологій (ІТКТ) залишаються недостатньо вивченими. З розвитком сучасних інформаційних технологій стало можливим створювати інтелектуальні системи підтримки прийняття рішень (ІСППР), здатні виконувати завдання управління такими великими системами, як інженерні мережі. У статті розглядається підхід до побудови ІСППР МІСситуаційного типу на основі нечіткої ситуаційної мережі. Такий підхід є універсальним і може слугувати потужним стимулом для створення інтелектуальних інформаційних технологій та розробки ефективних систем управління різними видами інфраструктурних об’єктів на території муніципального утворення. Наведений у статті алгоритм ситуаційного нечіткого керування базується на експертному методі формування та оцінки альтернатив управлінських рішень та структурній спільності орієнтованого графа нечіткої ситуаційної мережі.
Бібл. 18, іл. 5
Еволюція програмного забезпечення із перспективи систем
Authors: Ліневич О. , Лісовиченко О.
Published: June 2024

Об’єктами дослідження є методи розробки, які прискорюють еволюцію ПЗ. У статті зроблено огляд широковикористовуваних методів розробки і нового універсального методу, визначено причини довгої і непердбачуваної за часом еволюції систем, а також переваги нового методу для пришвидшення еволюції. Всьогобуло проаналізовано 8 методів, які включають метод абстракції, DDD, TDD, BDD, API Design First, RUP, гібридний і новий універсальний методи. Метою роботи є пришвидшення процесу еволюції ПЗ. Для досягнення мети пропонується новий метод, який аналізує дані і процеси варіантів використання як окремі системи і послідовно поєднуєза допомогою загальної теорії систем.
Бібл. 13, іл. 3, табл. 8
Аналіз електромагнітних процесів в перетворювачі з двадцятичотирьохзонним регулюванням напруги
Authors: Михайленко В. , Чуняк Ю. , Прудніков М.
Published: June 2024

У статті проведено аналіз електромагнітних процесів в електричних колах з напівпровідниковими комутаторами. Створено математичну модель перетворювача з дванадцятизонним регулюванням вихідної напруги для аналізу електромагнітних процесів у напівпровідникових перетворювачах з широтно-імпульсним регулюванням. Наведенографіки, що відображають електромагнітні процеси у електричних колах. Математична модель напівпровідникового перетворювача також використовується для дослідження перехідних процесів у напівпровідникових перетворювачах з активно-індуктивним навантаженням. Розвинуто метод багатопараметричних функцій, які входять до алгорит-мічних рівнянь аналізу усталених і перехідних процесів у розгалужених електричних колах з напівпровідниковими комутаторами і реактивними елементами, в напрямку урахування особливостей використання фазних і лінійних напруг мережі електроживлення. Розроблено нову математичну модель усталених і перехідних процесів у електричних колах напівпровідникових перетворювачів модуляційного типу з багатоканальним зоннимвикористанням фазних напруг трифазної мережі живлення без урахування втрат електроенергії у комутаторах для швидкої оцінки впливу параметрів навантаження на характеристики регульованих синусоїдних і постійних напруг. Результати цієї роботи можна використати для розвитку методу багатопараметричних модулюючих функцій дляспрощення аналізу перехідних процесів у електричних колах без врахуванням втрат у ключових елементах.
Бібл. 4, іл. 3
Тривимірні нейроні мережі у завданнях кластеризації
Authors: Паладієв О. , Лісовиченко О.
Published: June 2024

У даній роботі досліджуються можливості та ефективність застосування тривимірних нейронних мереж у задачах кластеризації. Автори розробили архітектуру тривимірної нейронної мережі та оцінили її здатність до кластеризації задопомогою індексу Данна. Результати дослідження показують високу ефективність запропонованої моделі порівняно з традиційними методами кластеризації, такими як K-середніх та ієрархічна кластеризація. Особливу увагу приділено аналізу просторових даних, де тривимірні нейронні мережі демонструють значні переваги у виявленні складних структур та формуванні чітких кластерів. Також розглянуто вплив різних параметрів мережі, включаючи кількість шарів та нейронів, на якість кластеризації. Запропонована модель може знайти широке застосування в різних областях, таких як медична діагностика, обробка зображень та аналіз соціальних мереж, де важливо ефективно групувати великі обсяги просторових даних.
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Identificationand Characterization of Proteus Species from Urine Samples in Federal Medical Center (FMC) Yenagoa, Bayelsa State, Nigeria
Authors: O Alade Tolulope , Raphael E. Mbam Omonibo E. F.
Published: June 2024

Urinary tract infections has remained a public health challenge and Proteus species have been implicated as the second commonest cause after Escherichia coli and Klebsiella species. Proteus species belong to the family of Enterobacteriaceae. Pathogenicity of Proteus mirabilis is enhanced by their possession of unique virulence factors which it uses to colonize the host urinary tract, including urease and stone formation, adhesions/fimbria, toxins, and hemolysin. The aimed at identifying and characterizing Protues species from urine samples of patients attending Federal Medical Center Yenagoa (FMCY). A total of 50 urine samples were collected and analyzed using standard phenotypic and 16S rRNA amplification techniques. Of the 50 urine samples collected, 18(36%) were collected from males while 32(64%) from females. Four (4) bacterial isolates were analyzed by 16S rRNA gene sequencing, and the phylogenetic tree was constructed to ascertain Proteus species to its species level. The antimicrobial susceptibility pattern showed that out of the 7(14%) isolates of Proteus species 3(42.86%), 7(100%), 6(85.71%), 1(14.29%), 5(71.43%), 7(100%), 0, 0, 6(85.71%) and 2(28.57%) were resistant to (Sulfamethaxozole-trimethoprim), (Chloramphenicol), (Sparfloxacin), (Ciprofloxacin), Ampicillin, (Augmentin), (Gentamicin), Perfloxacin, (Tarivid), and (Streptomycin). Results from the study showed that the molecular characterization confirmed the identity of the organism as was obtained from the phenotypic characterization of the isolates. The study revealed widespread resistance to most routine antimicrobials, which calls for proper surveillance against Proteus species.
Black Cumin (Nigella sativa L.) Variety Adaptation Trial at Bule Hora, West Guji zone, Ethiopia
Authors: Itana Taera , Ejigu Ijara Dejene Temesgen , Idos Gutema
Published: June 2024

Black cumin (Nigella sativa L.) is one of the most important spices and cash crops in Ethiopia. Despite its significance, the national average black cumin yield is low due to many constraints, including the unavailability of improved varieties for each growing and potential area. This research was conducted to evaluate the adaptability and yield potential of the released black cumin varieties. It was conducted at Bule Hora during the 2020–2022 cropping season, and six black cumin varieties were evaluated using a CRBD with three replications. The results of the analysis of variance showed the presence of significant variations among years for all traits and among varieties for traits like the number of primary branches, the number of pods per plant, and grain yield. However, no significant difference was observed for traits like days to flowering, days to maturity, plant height, and thousand seed weights among varieties and their interaction with the year. The highest seed yield was recorded for Kena (875.26 kg ha1), followed by Silingo (692.1 kg ha1), whereas the lowest grain yield was recorded for Darbera (570.4 kg ha1), followed by Kenani (628.14 kg ha1). Accordingly, Kena and Silingo black cumin varieties were selected based on their yield performance. The two selected varieties should be demonstrated and promoted in order to create demand among the farmers so as to produce black cumin in the area.
Diseases Susceptibility with Irritable Bowel Syndrome
Authors: Rani Jyoti , Karmakar Rimpa , Saini Sakshi
Published: June 2024

IBS is one of the most well-known functional bowel disorders, with more than 10% of the global adult population reporting symptoms consistent with the illness in population-based studies. In standard clinical practice, an IBS diagnosis is obtained based on common symptoms.3 Investigations are frequently limited to a chosen panel of tests that aid in the exclusion of established organic disorders with comparable symptoms, such as inflammatory bowel disease or celiac disease. The actual etiology of IBS is unknown, however anomalies in the gut-brain axis, increased gastrointestinal sensitivity, and dysregulation of gut motility and sensation are thought to have a role. There is evidence that people with IBS are more likely to have fibromyalgia, chronic fatigue syndrome, and depression than the general population. Furthermore, autoimmune illnesses such as rheumatoid arthritis and inflammatory bowel disease are more commonly associated with IBS. The precise processes causing this relationship are unknown, however it is thought that shared genetic, environmental, and neurological variables may contribute to both IBS and other disorders. Understanding this link is critical for effectively managing and treating both IBS and related comorbidities, potentially leading to more complete care plans for affected individuals. Diet has a substantial impact on susceptibility to Irritable Bowel Syndrome (IBS), a common gastrointestinal condition marked by stomach pain, bloating, and changes in bowel movements. Certain dietary components have been identified as triggers for IBS symptoms, which exacerbates the condition in sensitive individuals. Diet does not directly cause IBS, but it can have a substantial impact on illness susceptibility and symptom severity. Adopting a balanced diet high in soluble fiber, probiotics, and nutrient-dense foods while avoiding recognized trigger foods may help to control IBS symptoms and improve overall gastrointestinal health.
Energy Renormalization in a Berry Geometrical Phase: Low-Energy Perturbations of the Strong Interaction and the QCD Mass Gap
Authors: Gibbons Mark
Published: June 2024

A Berry geometrical phase is identified in a strongly metastable system containing dynamically responsive clathrate hydrate structures within a crystal-fluid material. High energy degeneracy in the associated chemistry produces local stability and false vacuum conditions that lead to non-extensive and non-additive contributions in the fundamental thermodynamic relation. Application of Ginzburg-Landau theory and the scaling laws reveals a coherence length and a penetration depth for a macro-scale dual superconductor. The coherence length determines non-extensive volume changes whilst its inverse gives the Higgs mass. The penetration depth determines the extent of QCD vacuum suppression whilst its inverse gives the vector boson mass together with indirect manifestation as non-additive hyperbolic curvature. Simultaneous emergence of the Ginzburg-Landau superconducting phase transition is consistent with gauge-invariant coupling of the scalar field to the Yang-Mills action in QCD. The discovery of an energy gap in the gradient energy term of the system Lagrangian is associated with a critical correlation length revealed in the transition from a gapped to a gapless superconducting state. Together with the emergence and absorption of the Higgs-like scalar field, a mechanism for describing a renormalized QCD mass gap arises.
SSR Markers-Based DNA Fingerprinting for Varietal Identification in Mango Cultivars
Authors: Ashraf Muhammad Aleem , Iqbal Javed , Shahid Imran , Kashif Muhammad , Li Yufeng , Kong Yu , Yu Naitong
Published: June 2024

Mango (Mangifera indica L.) is an allotetraploid (2n = 4X= 40) drupe fruit and has high nutritional value belongs to genus Mangifera and family Anacardiaceae. Mango cultivars are used with worldwide acceptance to pharmacological, ethnomedical, and phytochemical industries. Assessment of the genetic distinctiveness of a cultivar through morphological descriptors is an important tool for both the registration and the protection. New mango genotypes have been improved using valuable diverse germplasm resources to ensure food security. DNA fingerprinting based simple sequence repeats (SSR)-markers have been the most broadly used, effective and accurate in evaluation of genetic characterization of a cultivar. Molecular breeding is an effective source of genetic gain after improvement of fruit trees using marker assisted genomic selection. Total genomic DNA (gDNA) was generated using CTAB method from each cultivar. The most effective 50 hyper-variable SSR markers were selected. Highly specific DNA fingerprints were identified in the candidate line ‘Azeem Chaunsa’ compared with three standard cultivars using SSR-PCR. An agglomerative hierarchical clustering method was used to construct dendrogram based on the UPGMA clustering method. Cultivar identification diagram (CID) was constructed to evaluate association among standard cultivars and Azeem Chaunsa. Our results showed that SSR markers could efficiently assess genetic diversity in mango. The genetic similarity coefficients were recorded between the cultivars of mango ranged from 0.49 to 0.67. CID results concluded that cultivar ‘Azeem Chaunsa’ varied significantly from the check cultivar, Sindhri (46.2%), S.B Chaunsa (45%) and Sufaid Chaunsa (46.7%). The results obtained in this study will orient cultivar identification strategies for a successful future.
Prevalence of Anxiety in COPD Patients. Usefulness of the HADS Test for Establishing the Diagnostic Suspicion of Anxiety Through the Collaboration Between Primary Care, Pulmonology, and Psychiatry Services
Authors: Barrueco Enrique , HERNÁNDEZ-MEZQUITA Miguel Ángel , HIDALGO-SIERRA VANESA , CORDOVILLA ROSA , Olivera-Pueyo Javier , Galan Javier
Published: June 2024

Anxiety disorders, characterized by excessive fear and anxiety, are increasingly recognized as significant comorbidities in chronic diseases such as Chronic Obstructive Pulmonary Disease (COPD). This study aimed to evaluate the prevalence of anxiety in COPD patients referred from primary care centers to pulmonology services and identify predictive factors for anxiety. Conducted as a multicentric, observational, and prospective study, 293 COPD patients were recruited, undergoing comprehensive respiratory and smoking histories, spirometry, and anxiety assessments using the Hospital Anxiety and Depression Scale (HADS). These results show: a diagnosis of suspected anxiety in in 85 patients (29.0%): 17 possible and 68 with a strong suspicion. The study found significant associations between anxiety and factors such as gender (women showed a risk 3.5 times higher than men), weight, and body mass index (BMI). Disease severity, smoking status, and clinical manifestations did not significantly influence anxiety prevalence. The findings underscore the need for systematic psychological evaluations in COPD management, advocating for the use of simple diagnostic tools like the HADS to facilitate referrals to mental health services. Addressing anxiety in COPD patients could potentially improve their quality of life and disease outcomes. The study highlights the importance of a multidisciplinary approach involving family medicine, pulmonology, and psychiatry to optimize COPD patient care and suggests future research should focus on the impact of anxiety treatment on COPD progression. These insights call for integrating psychological assessments into routine clinical practice for comprehensive COPD management.
Mathematical Modeling and Sensitivity Analysis of Glioblastoma Growth and Dissemination: Insights from a Comprehensive Computational Framework
Authors: Montgomery Richard
Published: June 2024

Glioblastoma is a highly aggressive brain tumor characterized by rapid growth, extensive infiltration, and poor prognosis. Understanding the complex interplay of biological processes driving glioblastoma progression is crucial for developing effective therapeutic strategies. In this study, we present a comprehensive mathematical model that incorporates key aspects of glioblastoma growth and dissemination, including tumor cell diffusion, angiogenesis, nutrient availability, molecular signaling pathways, and blood-brain barrier (BBB) interactions. The model is based on a system of coupled partial differential equations (PDEs) and ordinary differential equations (ODEs) that capture the spatiotemporal dynamics of tumor cell density, nutrient concentration, signaling molecule concentrations, and BBB integrity. We employ numerical simulation techniques, such as the finite difference method and the Runge-Kutta method, to solve the model equations and visualize the evolution of tumor growth and its associated biological processes. The model parameters are estimated using experimental data from the literature, and the model is validated against clinical observations. Furthermore, we perform a comprehensive sensitivity analysis to identify the key parameters that significantly influence tumor growth, diffusion, and dissemination. The sensitivity analysis reveals the relative importance of each parameter in driving glioblastoma progression and highlights potential targets for therapeutic interventions. Our computational framework provides a powerful tool for understanding the complex dynamics of glioblastoma growth and offers valuable insights into the underlying biological mechanisms. The model can be used to test hypotheses, predict tumor response to various treatment strategies, and guide the design of targeted therapies. The findings from this study contribute to the ongoing efforts in developing personalized treatment approaches for glioblastoma patients and improving their clinical outcomes.
Sustainability and Stability: Asymmetric Time–Frequency Connectedness and Risk Spillovers Among EU–China ETSs, Clean Energy, Precious Metals, and Green Bonds
Authors: Yu Poshan , Chen Jianing , Xu Haoran
Published: June 2024

Emission trading schemes (ETSs) have become vital tools in striving toward global emission reduction objectives and promoting a sustainable economy. This paper empirically investigates the impact of market conditions on interconnectedness within precious metals, clean energy, green bonds, and carbon markets, focusing on China and the EU ETSs as the study subjects. A TVP-VAR-based asymmetric connectedness approach is adopted to capture the evolving relationships between the variables of interest in the time–frequency domain. The empirical findings reveal that: First, time-varying asymmetric connectedness and spillover effects among clean energy, precious metals, green bonds, and carbon markets are identified in both time and frequency domains under diverse market conditions, with long-term connectedness asymmetry being particularly sensitive, although spillovers exhibit variations. Second, the role and intensity of net transmitters or receivers vary across market conditions and frequency domains, indicating the complex and nuanced nature of market interactions. The EU ETS demonstrates a higher level of connectivity with global markets for clean energy, precious metals, and green bonds when compared to the Chinese ETS. However, it also shows greater susceptibility to fluctuations in market conditions. These results have significant implications for both investors striving to build sustainable diversified portfolios and regulators endeavoring to craft effective policies for risk regulation and sustainable development.
Lindernia dubia (L.) Pennel as an Alien Weed in Central Spain: A Case Study
Authors: Curt María Dolores , Sánchez Gema , Aguado Pedro Luis , Santín-Montanyá Inés
Published: June 2024

Lindernia dubia (L.) Pennell is a species with invasive behavior outside of its native range of distribution (North America), linked mainly to aquatic habitats. This annual species has been acknowledged as a weed in rice paddies in Europe and Asia. Due to the impacts of this invasive plant, some authors have even listed this species as a global invader. The present work focused on spontaneous plant species occurring in cattail seedlings grown in central Spain for the establishment of constructed wetlands. Weed inventory revealed the presence of L. dubia as a dominant spontaneous species in this crop environment. A suite of mesocosm experiments were designed to study the distribution of L.dubia versus the distribution of the other dominant plant species, and to determine traits associated with its weedy potential. Results showed that L.dubia presents competitive attributes such as morphological variability, early flowering, long seeding time, short growth cycle, small and light seeds and high seed production and germination rate (25 ⁰C), meaning a high reproductive capacity in a cycle of about three months, in non-limiting conditions for plant growth. Data from this work provide a basis for understanding the weedy potential of L.dubia, and for management decisions of a potentially invasive species, little investigated in Europe
Geological Insights from Porosity Analysis for Sustainable Development of Santos Basin’s Pre-Salt Carbonate Reservoir
Authors: Vásconez Garcia Richard Guillermo , Mohammadizadeh SeyedMehdi , Avansi Michelle Chaves Kuroda , Basilici Giorgio , Bomfim Leticia da Silva , Cunha Oton Rubio , Soares Marcus Vinícius Theodoro , Mesquita Áquila Ferreira , Mahjour Seyed Kourosh , Vidal Alexandre Campane
Published: June 2024

Carbonate reservoirs, influenced by depositional and diagenetic processes and characterized by features like faults and vugs that impact storage capacity, require more than traditional Borehole Imaging logs (BHI) for accurate porosity data. This data is essential for geological assessments, production forecasting, and reservoir simulations. This work aims to address this limitation by developing methods to measure and monitor the sustainability of carbonate reservoirs and exploring the application of sustainability principles to their management. The study integrates BHI and conventional logs from two wells to classify porosity-based facies within the Barra Velha Formation (BVF) in the Santos Basin. The methodology involves four steps: (i) analyzing conventional logs; (ii) segmenting BHI logs; (iii) integrating conventional and segmented BHI logs using Self-Organizing Maps (SOM); and (iv) interpreting the resulting classes. Matrix porosity values and non-matrix pore sizes categorize the porosity into four facies (A to D). Facies A has high non-matrix porosity with 14,560 small megapores, 5,419 large megapores, and 271 gigapores (71.9%, 26.76%, and 1.34% of the 20,250 pores, respectively). Facies B shows moderate non-matrix porosity with 8,669 small megapores, 2,642 large megapores, and 33 gigapores (76.42%, 23.29%, and 0.29% of the 11,344 pores, respectively) and medium matrix porosity. Facies C exhibits low non-matrix porosity with 7,749 small megapores, 2,132 large megapores, and 20 gigapores (78.27%, 21.53%, and 0.20% of the 9,901 pores, respectively) and medium matrix porosity. Facies D has low non-matrix porosity with 9,355 small megapores, 2,346 large megapores, and 19 gigapores (79.82%, 20.02%, and 0.16% of the 11,720 pores, respectively) and low matrix porosity. The novelty of this work lies in integrating data from two sources to classify porosity across the Pre-Salt reservoir interval, serving as a proxy for preliminary litho-facies identification without core data. This study advances our understanding of carbonate reservoir sustainability and heterogeneity, offering valuable insights for robust, sustainable reservoir characterization and management in the context of global environmental and geological changes.
Enhancing Dendritic Cell Cancer Vaccination: The Synergy of Immune Checkpoint Inhibitors in Combined Therapies
Authors: Zanotta Serena , Galati Domenico , De Filippi Rosaria , Pinto Antonio
Published: June 2024

Dendritic cell (DC) cancer vaccines are a promising therapeutic approach, leveraging the immune system to fight tumors. These vaccines utilize DCs' ability to present tumor-associated antigens to T cells, triggering a robust immune response. DC vaccine development has progressed through three generations. The first generation involved priming DCs with tumor-associated antigens or messenger RNA outside the body, showing limited clinical success. The second generation improved efficacy by using cytokine mixtures and specialized DC subsets to enhance immunogenicity. The third generation uses blood-derived DCs to elicit a stronger immune response. Clinical trials indicate that cancer vaccines have lower toxicity than traditional cytotoxic treatments. However, achieving significant clinical responses with DC immunotherapy remains challenging. Combining DC vaccines with immune checkpoint inhibitors (ICIs) such as anti-cytotoxic T-lymphocyte Antigen 4 and anti-programmed Death-1 antibodies has shown promise by enhancing T cell responses and improving clinical outcomes. These combinations can transform non-inflamed tumors into inflamed ones, boosting ICIs' efficacy. Current research is exploring new checkpoint targets like LAG-3, TIM-3, and TIGIT, considering their potential with DC vaccines. Additionally, engineering T cells with chimeric antigen receptors or T cell receptors could further augment the anti-tumor response. This comprehensive strategy aims to enhance cancer immunotherapy, focusing on increased efficacy and improved patient survival rates.