bluuebunny/crossref_metadata_2025 huggingface dataset:
Diarrhoea in Patients with COVID-19
Authors: Sheptulin A. A.
Published: January 2021

Aim. Revision of possible causes of diarrhoea in patients with the COVID-19 infection.Key points. Apart from respiratory symptoms, patients with the COVID-19 infection may also express gastrointestinal complaints, more frequently of diarrhoea (2–40% incidence rate). The causes of diarrhoea may relate to the virus direct interaction with the angiotensin-converting enzyme 2 (ACE2) receptors in mucosa, its impact on the intestinal microbiota and therapeutic side eﬀects. The possible occurrence of diarrhoea as a leading clinical manifestation of the coronavirus infection hampers its timely diagnosis. Published evidence on the impact of diarrhoea on the course of COVID-19 is contradictory.Conclusion. Epidemiological and clinical aspects of this problem require further research.
Deprescribing and Optimal Selection of Proton Pump Inhibitors (Contributions of the 26th United Russian Gastroenterology Week)
Authors: Ivashkin V. T. , Maev I. V. , Trukhmanov A. S. , Sheptulin A. A. , Simanenkov V. I. , Lapina T. L. , Khlynov I. B. , Dekhnich N. N. , Lopina O. D. , Alekseeva O. P. , Korochanskaya N. V. , Osipenko M. F. , Pavlov P. V. , Pirogov S. S. , Tarasova G. N. , Uspenskiy Yu. P. , Andreev D. N. , Rumyantseva D. E.
Published: January 2021

Aim. Presentation of the Forum “Deprescribing and optimal selection of proton pump inhibitors” held in Moscow on 29 September 2020 during the 26th United Russian Gastroenterology Week.Key points. The Forum was aimed at discussing issues associated with improving the proton pump inhibitor (PPIs) therapy in treatment and prevention of acid-related diseases and upper gastrointestinal tract (GIT) disorders induced by non-steroidal anti-inﬂammatory drugs (NSAIDs) and antiplatelet medications. Deprescribing is considered to be an eﬀective strategy of a motivated reduction of the PPI dosage, duration of therapy and the patient’s transfer from a regular to on-demand intake regimen. The choice of PPI may condition an optimal therapy for acid-related diseases.Conclusion. PPIs prevail in therapies for acid-related diseases and NSAID-induced upper GIT lesions. PPI deprescribing should be a strategy of choice if medically indicated. A non-enzymatic metabolism, high acid suppression, stable antisecretory eﬀect from day 1 of therapy and cytoprotective action justify the application of rabeprazole (Pariet®) for optimising therapies for acid-related diseases and implementing the deprescribing strategy.
Beyond the COVID-19 Pandemic: The Urgent Need to Expand Primary Care and Family Medicine
Authors: Geyman John P.
Published: January 2021

abstract: The COVID-19 pandemic, together with its resultant economic downturn, has unmasked serious problems of access, costs, quality of care, inequities, and disparities of US health care. It has exposed a serious primary care shortage, the unreliability of employer-sponsored health insurance, systemic racism, and other dysfunctions of a system turned on its head without a primary care base. Fundamental reform is urgently needed to bring affordable health care that is accessible to all Americans. Over the last 40-plus years, our supposed system has been taken over by corporate stakeholders with the presumption that a competitive unfettered marketplace will achieve the needed goal of affordable, accessible care. That theory has been thoroughly disproven by experience as the ranks of more than 30 million uninsured and 87 million underinsured demonstrates. Three main reform alternatives before us are: (1) to build on the Affordable Care Act; (2) to implement some kind of a public option; and (3) to enact single-payer Medicare for All. It is only the third option that can make affordable, comprehensive health care accessible for our entire population. As the debate goes forward over these alternatives during this election season, the likelihood of major change through a new system of national health insurance is becoming increasingly realistic. Rebuilding primary care and public health is a high priority as we face a new normal in US health care that places the public interest above that of corporate stakeholders and Wall Street investors. Primary care, and especially family medicine, should become the foundation of a reformed health care system.
O PLANEJAMENTO DE ENSINO PARA ALÉM DOS ELEMENTOS ESTRUTURANTES DE UM PLANO DE AULA
Authors: Brisolla Lívia Santos , De Assis Renata Machado
Published: January 2021

Este artigo tem por objetivo apresentar, do ponto de vista teórico, as concepções, as contribuições e os elementos de uma organização didática da aula que fundamentam o planejamento de ensino, por meio dos resultados de uma revisão integrativa de literatura. Assim, propõe-se repensar sua relevância para a organização do trabalho pedagógico da escola e da sala de aula a fim de recuperar o seu espaço no âmbito educacional. Defende-se o planejamento de ensino como um processo contínuo de reflexão, previsão e decisão acerca do trabalho pedagógico com vistas a aproximar escola e realidade social. Na discussão, aponta-se para a necessidade de transcender a atividade de planejamento que se apresenta burocrática, fragmentada e instrumental para percebê-la como um processo participativo, reflexivo, flexível, integrador e contínuo. Portanto, conclui-se a necessidade de repensar o planejamento de ensino para além dos elementos estruturantes de um plano de aula, que integre a escola e o contexto social na contramão da fragmentação do conhecimento, dos processos e das relações.
DIRETRIZES CURRICULARES DE ARTE (2008) E CREP-ARTE (2020)
Authors: Souza Alinne Martins de , Poroloniczak Juliana Aparecida
Published: January 2021

O trabalho aborda a implementação da Base Nacional Comum Curricular (BNCC) no Paraná e o abandono das Diretrizes Curriculares de Arte e, consequentemente, da Pedagogia Histórico-Crítica na Rede Estadual de Educação Básica, enquanto fundamentação teórico-metodológica da disciplina, repercutindo na fragilização e esvaziamento dos conteúdos do currículo de Arte. A proposta de mudança de grade curricular ocorre a partir de 2020, com a imposição do Currículo da Rede Estadual Paranaense (CREP). Tendo como base a problemática apresentada, traçamos primeiras impressões sobre este Currículo e apontamos possíveis consequências para a disciplina de Arte. As fontes documentais utilizadas na pesquisa são as Diretrizes Curriculares de Arte do Paraná (2008), o Referencial Curricular do Paraná (2018), o Currículo da Rede Estadual Paranaense (2019) e a BNCC (2017). Buscamos encontrar nos três últimos documentos citados suas conexões com o neoprodutivismo, neoescolanovismo, neoconstrutivismo, neotecnicismo, bem como o alinhamento destes com a reforma de cunho empresarial da educação. Nas Diretrizes Curriculares de Arte procuramos destacar as contribuições da Pedagogia Histórico-Crítica para a disciplina. Para fundamentar esta análise foram adotados autores como Saviani (2013; 2016), Duarte (2013), Zanotto e Sandri (2018) e Freitas (2018). Após a análise dos dados, constatamos que a disciplina de Arte concebida no CREP tende a descaracterizar a arte em seu potencial de humanização, transformando-a em mero instrumento para o desenvolvimento de habilidades e competências objetivadas na necessidade do mercado.
CONSELHO NACIONAL DE SECRETÁRIOS DE EDUCAÇÃO - CONSED
Authors: Thiesen Juares da Silva
Published: January 2021

O objetivo, no trabalho, é identificar o perfil do Conselho Nacional de Secretários de Educação – CONSED e relações de aproximação da entidade com racionalidades da internacionalização dos currículos, sobretudo no que tange ao Ensino Médio. Nesse sentido, apresentam-se aspectos da trajetória de atuação e protagonismos do Conselho, sua composição técnica e política e apontam-se elementos de alinhamento institucional com movimentos pela internacionalização. A exploração dos dados primários é feita pelo acesso a textos disponíveis em sites institucionais e documentos que discutem, de alguma forma, tópicos relacionados aos objetivos e projetos da referida entidade. Conclui-se que o CONSED se mostra comprometido com a perspectiva da internacionalização, atuando de braços dados com setores privados.
CURRÍCULO DE LETRAS (PORTUGUÊS-ESPANHOL)
Authors: Lazaro Rafael dos Santos , Miranda Claudia
Published: January 2021

O ensino do Espanhol como Língua Estrangeira (E/LE) se converteu em possibilidade de rupturas, em um contexto marcado pelo isolamento do Brasil com relação aos países do entorno. Os movimentos culturais que se constituíram na contramão do ethos colonial, têm mostrado alternativas para se estabelecer vínculos com diferentes áreas de pesquisa da América Latina (AL) e Caribe. Com essas orientações, tem sido possível vislumbrarmos ambientes formativos mais plurais, e menos unívocos. No presente artigo, indagamos o currículo de Letras (UFRRJ) para E/LE acerca de outras interconexões privilegiando, dessa vez, as afrolatinidades e o espaço curricular que ocupam.
O CONCEITO DE CRIATIVIDADE DOCENTE
Authors: Vieira Camila , Coimbra Silvia Gabrielle Braz
Published: January 2021

O conceito de criatividade docente e a imposição para uma reinvenção da escola e de seus profissionais no contexto atual é o ponto de partida deste artigo. Na primeira parte, será apresentado o conceito de criatividade docente como espaço de escuta e reflexão, constructo teórico parte do produto da tese de doutoramento de uma das autoras, o qual busca compreender os processos autoformativos docentes e de que forma a criatividade docente se vê favorecida quando este vivência espaços de formação nos quais a escuta e reflexão se fazem presentes. Na segunda parte, será discutido o contexto educacional pandêmico, vivido em escala mundial no ano de 2020 e as demandas oriundas pela reinvenção da escola e de seus docentes. Serão abordadas as estratégias para sua continuação a partir de modelos virtualizados/ não presenciais já existentes bem como do recém criado ensino remoto emergencial. Serão evidenciados alguns pontos de tensão em relação às novas estruturas gestadas e nas ressignificações oriundas do que se entende aqui como virtualidade da sala de aula e do trabalho docente. A necessidade de ser professor, mesmo que na adversidade, gestou espaços de criação muitas vezes pouco favoráveis para muitos docentes. A busca por respostas criativas desses profissionais, que muitas vezes se apresentam como “gambiarras pedagógicas” despontam como fatores que comprovam a urgência da discussão acerca da criatividade como temática formativa docente. Como finalização das análises, levantam-se maneiras de a criatividade estar presente mesmo quando em contextos adversos.
ESTUDOS SOBRE GÊNERO
Authors: Santos Mayra Silva
Published: January 2021

No texto Gênero: uma categoria útil de análise histórica, a autora traz algumas considerações sobre os estudos de gênero, enfatiza nessa perspectiva, as vertentes teóricas que embasam esses estudos no sentido de explicar o uso desse termo no decorrer dos séculos. Ao longo do texto, a autora vai tecendo discussões teóricas, explicando que o uso do termo gênero foi sendo construindo como forma de designar as relações sociais entre os sexos. Como uma importante teórica nos estudos sobre gênero, Scott considera o termo como uma categoria importante nos estudos sobre as diferenças sociais que foram construídas entre homens e mulheres. Defende nessa perspectiva, a teoria de Foucault sobre poder, no sentido de enfatizar que o termo pode ser compreendido por meio do entendimento sobre as relações de poder como redes dispersas e desiguais dotadas de intencionalidade e subjetividades. Estuda portanto, o gênero como categoria de análise em uma perspectiva histórica.
“PROFESSOR POSSO INVENTAR QUALQUER HISTÓRIA?”
Authors: Castro Bruno Fernando , Lopes Alice Casimiro
Published: January 2021

A pergunta provocadora presente no título, evocada a partir de uma experiência de aula, é o ponto de partida e de chegada da leitura apresentada sobre políticas curriculares em uma perspectiva pós-fundacional, a partir de textos recentes de Lopes e Macedo. Defendemos que pensar respostas para essa pergunta é importante para o contexto que vivemos de negacionismo e disputa de verdades. Sem defender uma verdade, queremos pensar a sala de aula como espaço para privilegiar processos de subjetivação resultantes de práticas de significação habitados pela indecidibilidade. Tentando responder à pergunta do título, apresentamos leituras desconstrucionistas em defesa do espaço escolar e da sala de aula como contextos que possibilitem a criação do sujeito que ainda não foi inventado e, ainda assim, assumam constantemente a contingência constituinte do mundo e que explicitem toda ação como prática falha de atribuição de sentidos, porque constituída pela diferença e suplementação de significados, que não possuem origem nem possibilidade de fechamento, mas que demandam respostas e hiperpolitizam os processos educacionais.
PESQUISA EM CURRÍCULO E DIFERENÇA
Authors: Ribeiro William , Ivenicki Ana , Honorato Rafael Ferreira de Souza
Published: January 2021

Temos com este dossiê o objetivo de alargar o sentido de diferença, não apenas em termos de pertencimentos variados, mas de formas de pensar, de ser e de se produzir conhecimentos sobre o mundo, o que pode nos ajudar na difícil tarefa de reconstruirmos caminhos multiculturais. Conforme Ivenicki (2018), pensar na formação de professores para o respeito à diversidade cultural e o desafio a preconceitos tem sido o foco do multiculturalismo para esta formação. Distintos esforços no âmbito da pesquisa, especialmente considerando a produção em educação, demonstram uma pluralidade de pretensões de rompimento com a herança violenta como temos lidado com a alteridade; produzindo novos léxicos, debates e contextos que põem em xeque, a despeito das distinções epistemológicas, bases pretensamente homogeneizadoras. Assim, este trabalho coletivo apresenta iniciativas diversas: multi/ interculturalismo crítico; pós/ de/ des colonialismo; pós-estruturalismo, estudos raciais, surdos, de gênero ou queer.
NOVAS TECNOLOGIAS NA CONDIÇÃO DO PÓS-MÉTODO
Authors: Borges Jadson de Carvalho , Ferreira Álex de Carvalho , Carvalho Eliane Gomes Oliveira de
Published: January 2021

Apresentamos nesse artigo uma visão dialogada entre a importância das novas tecnologias no ensino e as perspectivas da condição do pós-método (KUMARAVADIVELU, 2008). Embasado nos estudos de letramento digital (RIBEIRO, 2009; SOARES, 2002) e considerando a evolução da cibercultura, discutimos sobre a diversidade de métodos e modelos de ensino-aprendizagem, a fim de propor uma discussão sobre a emergência de desafios diversos no ensino e apontar caminhos para a convergência de abordagens que contemplem as demandas da sociedade da informação. Ao final desse artigo apresentamos as orientações para a pesquisa com novos letramentos propostas por Lankshear e Knobel (2013), que podem servir como parâmetro para os trabalhos com novas tecnologias na condição do pós-método.
POLÍTICAS PÚBLICAS PARA A EDUCAÇÃO INFANTIL: UM DEBATE SOBRE A EXPANSÃO DA OFERTA E A FORMAÇÃO DOS PROFESSORES
Authors: Souza Jorsinai de Argolo , Rios Jane Adriana Vasconcelos Pacheco , Oliveira Rosemary Lapa de
Published: January 2021

O artigo versa sobre relações entre políticas públicas de expansão da oferta da Educação Infantil e condições favoráveis para o processo de ensino e aprendizagem, incluindo a formação de professores. Discute desafios dessa etapa associados à infraestrutura física das escolas, às questões didático-pedagógicas e o financiamento, ampliando o debate sobre o papel e formação do professor no cenário político, econômico e social. Apresenta o processo de revogação das Diretrizes Curriculares Nacionais para a Formação de Professores (DCNFP) e a implantação das Diretrizes Curriculares Nacionais para a Formação Inicial de Professores para a Educação Básica que institui a Base Nacional Comum para a Formação Inicial de Professores da Educação Básica-BNC Formação. Evidencia que há distância entre a política de acesso e a garantia de condições para o processo de ensino e aprendizagem nas instituições de Educação Infantil e propõe a efetivação do sistema de colaboração entre União, Estados e Municípios e a revisão de novas fontes de financiamento para a educação, além do Fundo de Manutenção e Desenvolvimento da Educação Básica e de Valorização dos Profissionais da Educação (FUNDEB). Objetiva sinalizar a mobilização de entidades, sindicatos e educadores contra o desmonte da educação pública e garantir direitos educacionais e profissionais conquistados.
CONSTITUIÇÃO DA IDENTIDADE PROFISSIONAL E DOS SABERES DOCENTE: TERRITÓRIOS DA EXPERIÊNCIA
Authors: Bezerra Paloma Oliveira
Published: January 2021

O presente artigo apresenta uma análise sobre identidade profissional e saberes docentes na perspectiva do saber da experiência. Essa discussão tem como finalidade compreender como se dá a constituição da identidade profissional docente, articulando a construção/mobilização dos saberes a concepção de experiência. A opção metodológica adotada é definida como qualitativa, dado o seu caráter interpretativo. A construção dos dados tornou-se possível por meio de entrevista narrativa e da análise de conteúdo como técnica de análise dos dados. Observou-se que para os sujeitos da pesquisa, é na relação inextricável entre o eu pessoal e o profissional que o professor vai construindo sua identidade. Desse modo, apontamos a importância de despertar, nos professores, a vontade de refletir sobre os seus percursos profissionais, sobre a forma como sentem a articulação entre o profissional e o pessoal, sobre a constituição da identidade e os saberes próprios do exercício docente, sobre a identidade profissional e os saberes docentes em constate (trans)formação.
Immune Responses in Mice Vaccinated with Virus-Like Particles of Western Equine Encephalitis Virus from an Insect Cell-Based Expression System
Authors: Ma Jinzhu , Wang Hualei , Zheng Xuexing , Wu Hongxia Wu , Yang Songtao , Xia XIanzhu
Published: January 2021

Western equine encephalitis virus (WEEV) can cause lethal encephalitis
in humans and equines and represents a serious public health threat in
many countries. Therefore, development of efficient vaccines against
WEEV remains an important challenge in the field of disease control.
This study described for the first time successful production of WEEV
virus-like particles (VLPs) in insect cells using recombinant
baculoviruses. This well-established expression system is very suitable
for production of WEEV VLPs. The immune experiment herein in mice showed
that the VLPs formulated with 206-adjuvant were responsible for the
stronger-VLP-specific cellular immune response, and were able to induce
the secretion of IL-2, IL-4, IFN-γ and production of high titer
antibodies that can effectively neutralize the WEEV pseudoviruses. The
WEEV VLPs from insect cells could provide a new, safe, non-replicating
and effective vaccine candidate against WEEV infections.
Evaluation of fetal condition in uncomplicated pregnancies at 40 weeks and beyond by calculation of amniotic fluid indexes and Doppler in the middle cerebral artery.
Authors: semenova elvira , Rukhliada Nikolai , Klicenko Olga
Published: January 2021

Objective. The aim of our data is to reveal the method of prognosis
abnormal perinatal outcome, using combination US and Doppler results in
uncomplicated pregnancies at 40 weeks and beyond. Design.1020
uncomplicated pregnant women at 40 weeks and beyond were examined 48
hours before delivery. We analyzed fetus’s condition during labor and
just after. Setting. According these dates all women were divided into 3
groups after amniotic index(AI)and pulsatility indices(PI) in the middle
cerebral artery(MCA). Population.260 women were included in the study
because they met the inclusion criteria. Methods.All women were divided
into 3 groups (group 1 - PI>0.835, any value of AI, group
2-AI >85, PI ≤ 0.835, group 3- AI ≤ 85 and PI ≤ 0.835).We
analyzed fetus’s condition during labor and just after delivery (Apgar
score <=7 and >7 on the 1st minute). Result.
We’ve got trigger level for pulsatility index (PI) as 0.835, if we had
PI less than that threshold cases of emergency cesarean section
increases in 2,12 times, if PI less than 0,835 in combination with
Amniotic Index(AI) 85 and less in 5,28 times. If PI =<0,835
risk of newborns having Apgar 7 and less increases in 1,18, but in
combination with AI =<85 in 4,72 times. Conclusion. In results
we found out the following data: low PI in the MCA may be parameter
which cans prognoses fetus distress. Combination of PI reduce with low
AI increases its specific and can use in practical ways to avoid hypoxic
brain damage during labor.
REAL-WORLD CLINICAL OUTCOMES ASSOCIATED WITH CANAGLIFLOZIN IN PATIENTS AGED 65 YEARS AND OLDER WITH TYPE 2 DIABETES MELLITUS IN SPAIN: THE OLD REAL-WECAN STUDY.
Authors: GARGALLO-FERNANDEZ MANUEL , Sanz-Pastor Alba Galdón , Antón-Bravo Teresa , BRITO-SANFIEL MIGUEL , Wong-Cruz Jaime , GORGOJO-MARTINEZ JUAN JOSE
Published: January 2021

Abstract Objectives The observational REAL WECAN study showed that
canagliflozin 100 mg (CANA100) as add-on therapy, and canagliflozin 300
mg (CANA300), switching from prior SGLT-2i therapy, significantly
improved several cardiometabolic parameters in patients with T2DM. The
aim of this sub-analysis was to assess the effectiveness and safety of
canagliflozin in patients aged >65 years. The primary
outcome of the study was the mean change in HbA1c over the follow-up
time. Materials and Methods 583 patients met the inclusion criteria
(39.5% > 65 years), 279 in the CANA100 cohort (36.9 %
> 65 years, mean HbA1c 8.05%) and 304 in the CANA300
cohort (41.8 % > 65 years, mean HbA1c 7.51%). Results In
the CANA100 cohort, older patients showed significant reductions in
HbA1c (-0.78%) and weight (-4.5 kg). Patients aged >65
years switching to CANA300 experienced a significant decrease in HbA1c
(-0.27%) and weight (-2.1 kg). There were no significant differences in
HbA1c and weight reductions when the cohorts of patients <65
and >65 years were compared in a multiple linear regression
model. The safety proﬁle of canagliﬂozin was similar in both age groups.
Conclusion These ﬁndings support canagliﬂozin as an effective
therapeutic option for older adults with T2DM
AN ADAPTIVE DISCONTINUOUS GALERKIN METHOD FOR A STOKES/BIOT FLUID-POROELASTIC STRUCTURE INTERACTION MODEL
Authors: HOUEDANOU Wilfrid
Published: January 2021

The paper presents an a posteriori error estimator for a (piecewise
linear) nonconforming finite element approximation of the problem
defining the interaction between a free fluid and poroelastic structure.
The free fluid is governed by the Stokes equations, while the flow in
the poroelastic medium is modeled using the Biot poroelasticity system.
Equilibrium and kinematic conditions are imposed on the interface. The
approach utilizes the same nonconforming Crouzeix-Raviart element
discretization on the entire domain [Houédanou Koffi Wilfrid, Results
in Applied Mathematics 7 (2020) 100127, Elsevier]. For this
discretization, we derive a residual indicator based on the jumps of
normal derivative of the nonconforming approximation. Lower and upper
bounds form the main results with minimal assumptions on the mesh.
Off Pump Coronary Artery Bypass in patients with severe LV dys-function. Is it really more challenging?
Authors: Sarris-Michopoulos Panagiotis , Markell Evan , Macias Alejandro , Magarakis Michael
Published: January 2021

CABG (Coronary Artery Bypass Grafting) has been the treatment of choice
for coronary artery disease for over 50 years and is the most common
cardiac surgery procedure performed. Traditionally CABG was performed
with the use of cardiopulmonary bypass and the use of cardioplegia to
allow the surgeon to operate on a stable field. In the mid-1990s,
interest emerged in performing CABG without the use of cardiopulmonary
bypass - off pump CABG. This invited commentary focuses on sharing our
experience with Low Ejection fraction off-pump CABG and why this
approach could be beneficial to this patient population.
Placenta accreta after postpartum tubal sterilisation and Novasure® endometrial ablation
Authors: Igbokwe Nnadozie , Glackin Kevin , Kaur Harpreet
Published: January 2021

A case of a 42-year-old woman, Para 3 who had an unplanned pregnancy
despite bilateral tubal ligation for contraception, and Novasure®
endometrial ablation for persistent Heavy Menstrual Bleeding (HMB). The
pregnancy was complicated by missed miscarriage at 14 weeks and placenta
accreta. This is an uncommon event.
Prenatal diagnosis of partial absence of the tricuspid valve with conoventricular septal defect - The utility of prenatal 4-Dimensional Spatiotemporal Image Correlation Rendering.
Authors: Karmegaraj Balaganesh , Manickavasagam Madhubala , Ibrahim Syed , Syed Mohamed Razeen , Srimurugan Balaji
Published: January 2021

First described in 1965 by Johnson and Wilcox, partial absence of the
tricuspid valve (TV) associated with a ventricular septal defect(VSD) is
a very rare malformation.(1) Heart failure secondary to severe TV
regurgitation results in-utero fetal compromise. (2) We present here a
fetus with partial absence of the tricuspid valve with conoventricular
septal defect.
Existence results for some fractional differential equations related to A ∈ B(L2[a, b])
Authors: Bayati Eshkaftaki
Published: January 2021

In this paper we define the (generalized) linear Volterra integral operator
on L2[a, b]. Then the problem of existence and uniqueness of solutions of
the second kind Volterra integral equations, corresponding to this operator,
will be answered. Finally, some applications of this work to the existence
of solutions of some fractional differential equations, are given.
Parabolic local Campanato estimates for commutators of parabolic fractional maximal and integral operators with rough kernel
Authors: Gürbüz Ferit
Published: January 2021

In this paper, the author introduces parabolic generalized local Morrey
spaces and parabolic local Campanato spaces, respectively and also
establishes parabolic local Campanato estimates for commutators of parabolic
fractional maximal and integral operators with rough kernel on parabolic
generalized local Morrey spaces.
Galois connection of stabilizers in residuated lattices
Authors: Rasouli Saeed
Published: January 2021

The paper is devoted to introduce the notions of some types of stabilizers in
non-commutative residuated lattices and to investigate their properties. We
establish a connection between (contravariant) Galois connection and
stabilizers of a residuated lattices. If A is a residuated lattice and F be
a filter of A, we show that the set of all stabilizers relative to F of a
same type forms a complete lattice. Furthermore, we prove that ST - F?l,
ST - Fl and ST - Fs are pseudocomplemented lattices.
The convex properties and norm bounds for operator matrices involving contractions
Authors: Li Yuan , Cui Mengqian , Hu Shasha
Published: January 2021

In this note, the norm bounds and convex properties of special operator
matrices ~H(m)n and ~S(m)n are investigated. When Hilbert space K is
infinite dimensional, we firstly show that ~H(m)n = ~H(m)n+1 and ~S(m) n
= ~S(m)n+1, for m, n = 1,2,.... Then we get that ~H(m) n is a convex
and compact set in the ?* topology. Moreover, some norm bounds for ~H(m) n and ~S(m)n are given.
Crossed products of Hom-Hopf algebras
Authors: Lu Daowei , Li Yizheng , Guo Shuangjian
Published: January 2021

Let (H,?) be a Hom-Hopf algebra and (A,?) be a Hom-algebra. In this paper
we will construct the Hom-crossed product (A#?H???), and prove that the
extension A ? A#?H is actually a Hom-type cleft extension and vice versa.
Then we will give the necessary and sufficient conditions to make (A#?H???)
into a Hom-Hopf algebra. Finally we will study the lazy 2-cocycle on (H,?).
Viscosity explicit midpoint methods for nonexpansive mappings in Hadamard spaces
Authors: Preechasilp Pakkapon
Published: January 2021

In this paper, the viscosity explicit midpoint method for nonexpansive
mappings in Hadamard spaces is introduced. Under certain appropriate
conditions on the sequence of parameters, it is proved that the limit of the
approximating sequence generated by proposed method converges strongly to a
fixed point of T which solves some variational inequalities. Moreover, we
give an application to the equilibrium problem.
Description of the statistical variations of the measured strength for brittle ceramics: A comparison between two-parameter Weibull distribution and normal distribution
Authors: Deng Bin , Wang Xingang , Jiang Danyu , Gong Jianghong
Published: January 2021

It is generally assumed that the measured strength of brittle ceramics
follows a Weibull distribution. However, there seems to be few sound and
direct evidences to support this assumption. Several previous studies have
shown that other distributions, such as normal distribution and log-normal
distribution may describe more appropriately the strength data than Weibull
distribution. In this paper, the efficiency of using a normal distribution
to describe the strength which follows a Weibull distribution is examined
based on Monte-Carlo simulations. It was shown that there exist strong
correlations between the parameters of normal distribution and those of
Weibull distribution. For the designed fracture probability not lower than
0.01, analyses based on both normal distribution and Weibull distribution
may give nearly identical predictions for the applicable stress levels. For
lower fracture probabilities, the differences between the predictions of
both distributions are not significant. It was suggested that, if there is
no evidence to confirm that the measured strength follows a certain
distribution, normal distribution and Weibull distribution seem to have the
same efficiency in analysing the statistical variations in the measured
strength of ceramics.
Influence of wet chemical processing conditions on structure and properties of magnetic hydroxyapatite nanocomposites
Authors: Jakab Miklos , Enisz-Bódogh Margit , Makó Éva , Kovács Kristóf , Orbán Szabolcs , Horváth Barnabás
Published: January 2021

Nanostructured composites containing iron oxide and hydroxyapatite (m-HA)
were prepared by two wet chemical methods (single-step and double-step
process) having different order of magnetite and HA precipitations. The phase
composition, crystal size and lattice constants of the prepared composites
were determined by XRD, the functional groups by FTIR and the structure,
morphology and elemental composition by TEM. The magnetic susceptibility
values and the colour indexes of each composite were also determined.
Biocompatibility testing was performed in simulated body fluid. The results
show that the composites produced by different (single-step and double-step)
co-precipitating methods show different chemical and phase composition,
average particle size, and therefore different superparamagnetic properties
and bioactivities, with possibilities for different applications.
COVID-19 in everyday life: Contextualizing the pandemic
Authors: Ristic Dusan , Pajvancic-Cizelj Ana , Cikic Jovana
Published: January 2021

This paper provides an overview and findings of the research on the social
aspects of COVID-19 pandemic in Serbia. We aimed to investigate the
immediate impact of the COVID-19 pandemic on everyday life. The general
hypothesis was that it contributed to changes in common rituals and
routines, especially in the areas we focused on: family and housework,
trust, the Internet use, and food practices. The study involved an online
survey on the sample of 685 respondents, adult citizens of the Republic of
Serbia. The main criterion for the selection of respondents was their legal
age. The research was conducted during April 2020. We present and discuss
the findings, give preliminary conclusions, and contextualize them within
the current studies on the COVID-19 outbreak. The general research
hypothesis has only been partially confirmed. Our findings suggest that the
pandemic outbreak has disrupted people?s habitual established practices and
strategies for managing daily life in the sense of either intensification or
the absence of certain routines.
Upper Blepharoplasty
Authors: Ballard Tiffany N , Gilman Robert H
Published: January 2021

This article is intended to provide the practitioner with the basics of upper lid blepharoplasty. We discuss the normal anatomy of the upper eyelid and its relationship to facial aesthetics. We also discuss the evaluation for upper eyelid surgery and surgical planning. We present the author’s preferred operative technique and talk about some variations in approach. We also discuss potential postoperative complications and patient outcomes. The illustrations and photographs are supplemented with video materials.
 
This review contains 6 figures, 12 videos and 25 references
Key Words: blepharochalasis, green forceps, lacrimal duct, lacrimal gland, levator palpebrae, levator  aponeurosis, Müller’s muscle, orbital fat, orbicularis oculi, orbital septum, preseptal, postseptal, ROOF, tarsal fold, tarsal plate, skin-pinch technique
Neurobiology of Personality Disorders
Authors: Costales Theresa , Goodman Marianne , Kapil-Pair Kalpana , Marin Lea , Pier Katherine , Wilsnack Jaime
Published: January 2021

Personality disorders affect an estimated 9.1% of the general population, including 25 to 50% of psychiatric outpatients and up to 80% of inpatients. They constitute heterogeneous clinical presentations characterized by interpersonal deficits owing to disturbances in self and interpersonal functioning. Personality disorders frequently co-occur with other psychiatric conditions and tend to be refractory to traditional pharmacologic treatments, and patients with these disorders have a reduced quality of life and carry significant risk of death by suicide. Research over the last 25 years has advanced our understanding of the neurobiology, neurochemistry, physiology, genetics, and epigenetics that contribute to these complex presentations. A review of the neurobiological basis of personality disorders demonstrates that, in most cases, personality pathology represents a confluence of traits that are on a spectrum with normal personality functioning and other mental disorders. Schizotypal personality disorder, borderline personality disorder, antisocial personality disorder, avoidant personality disorder, and obsessive-compulsive personality disorder are among the disorders with sufficient evidence to support their conceptualization as discrete nosologic entities. Functional neuroimaging and connectivity studies, as well as genetic and epigenetic research, have highlighted structural, neurochemical, environmental, and behavioral targets that hold promise for treatment.
This review contains 6 figures, 6 tables, and 116 references.
Key words: antisocial, avoidant, borderline, connectivity, functional magnetic resonance imaging, heritability, obsessive-compulsive, personality, personality disorder, schizotypal
Inflammation, Coagulation, and Fibrinolysis in Venous Thrombosis
Authors: Diaz Jose A. , Wakefield Thomas W.
Published: January 2021

Deep vein thrombosis (DVT) refers to the formation of one or more thrombi within the deep veins, most commonly in the lower limbs. In the acute phase, DVT may result in significant morbidity in the affected extremity due to obstruction of venous outflow and may be life threatening as a consequence of pulmonary embolism (PE). Together DVT and PE are collectively referred to as venous thromboembolism (VTE). In 2008, the surgeon general’s call to action to prevent DVT and PE stated that “the disease disproportionately affects older Americans, and we can expect more suffering and more deaths in the future as the population ages—unless we do something about it,” inviting multiple stakeholders to come together in a coordinated effort to reverse this dramatic projected trend. Thus, VTE is not only a health issue but also a serious socioeconomic problem that needs to be fully understood to be addressed. This review presents the epidemiology and the current information regarding molecules and cells involved in the pathogenesis of venous thrombosis (VT), including lessons learned from animal models on VT. A table outlines risk factors for the development of VTE. Illustrations depict acute and chronic VT, and statins preventing VT.
This review contains 2 figures, 1 table, and 137 references.
Clinical Impact of Residual C-Peptide Secretion in Type 1 Diabetes on Glycemia and Microvascular Complications
Authors: Jeyam Anita , Colhoun Helen , McGurnaghan Stuart , Blackbourn Luke , McDonald Timothy J , Palmer Colin N A , McKnight John A , Strachan Mark W J , Patrick Alan W , Chalmers John , Lindsay Robert S , Petrie John R , Thekkepat Sandeep , Collier Andrew , MacRury Sandra , McKeigue Paul M
Published: January 2021

Objective: To quantify the
relationship of residual C-peptide secretion to glycemic outcomes and
microvascular complications in type 1 diabetes.

Design
and Methods: C-peptide was measured in an untimed
blood sample in the SDRNT1BIO cohort of 6076 people with type 1 diabetes
followed for an average of 5.2 years.

Results:
In regression models adjusted for age at onset and
duration, effect sizes for C-peptide ≥200 versus <5 pmol/l were as follows:
insulin dose at baseline 27% lower (p=2×10−39), HbA1c
during follow-up 4.9 mmol/mol lower (p=3×10−13), hazard
ratio for hospital admission for diabetic ketoacidosis during follow-up 0.44
(p=0.0001), odds ratio for incident retinopathy 0.51 (p=0.0003). Effects on risk of serious hypoglycemic
episodes were detectable at lower levels of C-peptide, and the form of the
relationship was continuous down to the limit of detection (3 pmol/l). In regression models contrasting C-peptide 30
to <200 with <5 pmol/l, the odds ratio for self-report of at least one
serious hypoglycemic episode in the last year was 0.56 (p=6×10−8),
and the hazard ratio for hospital admission for hypoglycemia during follow-up
was 0.52 (p=0.03).

Conclusion:
These results in a large representative cohort
suggest that even minimal residual C-peptide secretion could have clinical
benefit in type 1 diabetes, in contrast to a follow-up study of the DCCT
intensively-treated cohort where an effect on hypoglycemia was seen only at
C-peptide levels ≥130 pmol/l. This has
obvious implications for design and evaluation of trials of interventions to
preserve or restore pancreatic islet function in type 1 diabetes.
Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes among Normoglycemic Chinese Adults: Findings From the 4C Study
Authors: Lu Jieli , Wang Shuangyuan , Li Mian , Gao Zhengnan , Xu Yu , Zhao Xinjie , Hu Chunyan , Zhang Yi , Liu Ruixin , Hu Ruying , Shi Lixin , Zheng Ruizhi , Du Rui , Su Qing , Wang Jiqiu , Chen Yuhong , Yu Xuefeng , Yan Li , Wang Tiange , Zhao Zhiyun , Wang Xiaolin , Li Qi , Qin Guijun , Wan Qin , Chen Gang , Xu Min , Dai Meng , Zhang Di , Tang Xulei , Wang Guixia , Shen Feixia , Luo Zuojie , Qin Yingfen , Chen Li , Huo Yanan , Li Qiang , Ye Zhen , Zhang Yinfei , Liu Chao , Wang Youmin , Wu Shengli , Yang Tao , Deng Huacong , Li Donghui , Lai Shenghan , Mu Yiming , Chen Lulu , Zhao Jiajun , Xu Guowang , Bi Yufang , Ning Guang , Wang Weiqing
Published: January 2021

OBJECTIVE

Comprehensive
assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We aim to examine
the association of serum BA profile and co-regulation with the
risk of developing type 2 diabetes (T2DM) among normoglycemic Chinese adults.

RESEARCH
DESIGN AND METHODS

We tested 23 serum BA species in subjects with
incident diabetes (n=1707) and propensity score (including age, sex, BMI and fasting glucose)–matched controls (n=1707) from
the China Cardiometabolic Disease and Cancer Cohort(4C) Study, which was composed of 54807 normoglycemic Chinese adults with a median follow-up
of 3.03 years. Multivariable-adjusted odds
ratios(ORs) for associations of BAs with T2DM were estimated using conditional
logistic regression.

RESULTS

In multivariable-adjusted logistic regression analysis, per
SD increment of unconjugated primary and secondary BAs were inversely associated
with incident diabetes, with the OR (95% CI) of 0.89(0.83-0.96) for cholic acid,
0.90(0.84-0.97) for chenodeoxycholic acid and 0.90(0.83-0.96) for deoxycholic
acid (P<0.05 and FDR<0.05). On the other hand, conjugated primary BAs (glycocholic
acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic
acid and sulfated glycochenodeoxycholic acid) and secondary
BA (tauroursodeoxycholic acid) were positively related with incident diabetes,
with ORs ranging from 1.11 to 1.19(95% CIs ranging between 1.05 and 1.28). In fully adjusted model additionally adjusted for
liver enzyme, HDL, 2 hour-postload glucose, HOMA-IR and waist
circumference, the risk estimates are similar. Differential correlation network
analysis revealed that perturbations in intra-class (i.e. primary and
secondary) and interclass (i.e. unconjugated and conjugated) BAs co-regulation preexisted before diabetes
onset.

CONCLUSIONS

These findings reveal
novel changes in BA exist prior to incident type 2 diabetes and support a potential
role of BA metabolism in the pathogenesis of diabetes.
Generation of Bessel-beam arrays for parallel fabrication in two-photon polymerization
Authors: Cheng He , Xia Chun , Kuebler Stephen M. , Golvari Pooria , Sun Mingman , Zhang Meng , Yu Xiaoming
Published: January 2021

Microfabrication based on two-photon polymerization (TPP) is typically achieved by scanning a focal spot point-by-point. This is a type of serial processing that significantly limits fabrication speed. Bessel beams known for their nondiffracting property are suitable for the fabrication of high-aspect-ratio microstructures without scanning the beams. The zero-order Bessel beam generated by an axicon or a spatial light modulator (SLM) has been used to fabricate such structures as polymer fibers with an aspect ratio exceeding 500:1. However, the fabrication speed is still limited by the serial exposure of a single Bessel beam. In this paper, the authors explore a method for parallel fabrication of high-aspect-ratio microstructures using an array of high-order Bessel beams. An optics system is built in which high-order and superposed high-order Bessel beams generated by an SLM are demagnified and relayed to the photopolymer. These beams retain the same nondiffracting property as the zero-order beam while expanding the exposure light field to arrays of beams. Beam profiles are characterized and compared with theoretical predictions. The power efficiency of the system is measured and analyzed. The influence of off-axis illumination on the SLM is studied. Combined with suitable photopolymer and exposure parameters, this method could be useful for high-speed, volumetric fabrication in TPP.
Murders in the German Sex Trade: 1920 to 2017
Authors:   Sex Industry Kills Research Project, Germany, Schon Manuela , Hoheide Anna ,   Sex Industry Kills Research Project, Germany
Published: January 2021

This research report is the result of collecting and evaluating data on cases of homicides and attempted homicides in the German sex trade from 1920-2017. The findings show violence against prostituted women and the attitudes of the sex buyers who commit most of the violent acts against the women. The report discusses the media coverage of murder cases, complication of cases, and a critique of methods of criminal evaluation by the police. From 1920 to 2017, 272 victims of murder and attempted murder were identified. Liberalization of prostitution occurred in 2002. From then until 2017, there is a decrease in the number of victims who died, the number of victims of attempted murder dramatically increased. It appears that victims were more likely to survive an attempted murder. Profiles of the victims are included as well as the locations (indoors v outdoors) of the murders. The authors conclude that legalization of prostitution does not eliminate the murders or attempted murders of women in the sex trade in Germany.
Skriving i naturfag: En analyse av nettbaserte undervisningsressurser fra to nasjonale sentre
Authors: Lorentzen Vibeke , Igland Mari-Ann , Solheim Randi
Published: January 2021

Denne artikkelen er basert på en studie av et utvalg ressurser om skriving i naturfag, hentet fra nettsidene til Skrivesenteret og Naturfagsenteret. I Læreplanverket for Kunnskapsløftet inngår skriving som grunnleggende ferdighet i alle fag, som en gjennomgående og tverrfaglig kompetanse. De nasjonale sentrene skal, ifølge sine mandat, støtte skolene i arbeidet med å implementere de grunnleggende ferdighetene. Spørsmålet vi søker svar på i denne artikkelen, er hvordan fagrelevant skriving og skriveopplæring er forstått og formidlet i nettressurser fra de to sentrene. Analysene viser at faginnhold og faglige uttrykk vektlegges på ulike måter, noe som kan knyttes til ulike syn på faglig literacy. Mens Naturfagsenterets skrivedidaktiske ressurser primært presenterer fagovergripende perspektiver på skriving i naturfag, legger Skrivesenteret i større grad vekt på fagspesifikke språktrekk og uttrykksmåter. Disse funnene blir drøftet i lys av literacy-forskning og utdanningspolitiske endringer.
English abstract
English title: Writing in science education: An analysis of web-based resources from two national centres
This article is based on a study of web-based resources for writing in science education, published by The Norwegian Centre for Science Education and the Norwegian Centre for Writing Education and Research. The Norwegian Curriculum includes writing as a basic skill in all subjects, as a comprehensive and interdisciplinary competence. The national centres should, according to their mandates, support schools in their efforts to implement the statutory basic skills. The question we seek answer to in this article, is how disciplinary writing and writing education is understood and communicated in the two centres’ web resources. The analysis shows that subject content and subject discourse are emphasized in different ways. This can be related to different perspectives on academic literacy. While the Norwegian Centre for Science Education’s writing resources primarily present generic perspectives on writing, the Writing Centre places greater emphasis on linguistic and textual features of scientific texts. These findings are discussed against a backdrop of literacy research and educational policies.
Aktivitas dan Hasil Belajar Peserta didik pada Implementasi Online Discovery Learning
Authors: Sumendra Made Yasa
Published: January 2021

Tujuan penelitian ini adalah untuk: (1) Meningkatkan aktivitas belajar dan hasil belajar peserta didik Kelas XI Akuntansi 1 semester I tahun pelajaran 2020/2021 SMK Negeri 2 Seririt dengan model pembelajaran Online Discovery Learning; (2) Mendeskripsikan tanggapan peserta didik terhadap implementasi Online Discovery Learning kelas XI Akuntansi 1 semester I tahun pelajaran 2020/2021 SMK Negeri 2 Seririt. Penelitian ini merupakan jenis penelitian tindakan kelas, diimplementasikan dalam dua siklus. Data yang dikumpulkan dan dianalisis berupa nilai aktivitas belajar dan hasil belajar. Berdasarkan hasil dan pembahasan maka dapat disimpulkan: (1) implementasi model pembelajaran Online Discovery Learning dapat meningkatkan aktivitas belajar dan hasil belajar peserta didik kelas XI Akuntansi 1 pada semester I tahun pelajaran 2020/2021 SMK Negeri 2 Seririt; (2) implementasi model pembelajaran Discovery Learning dapat mengakomodasi peningkatan tingkat kepuasan peserta didik dalam belajar.