bluuebunny/crossref_metadata_2025 huggingface dataset:
Is There a Relationship between Pressure Gradients through Contemporary Oxygenators and Immune Cell Proliferation during Cardiopulmonary Bypass? A Pilot Study
Authors: Stanzel Roger D.P. , Henderson Mark
Published: July 2023

There have been many advances in the perfusion equipment used for cardiopulmonary bypass (CPB) surgery. A key component, the membrane oxygenator, has had a number of modifications in recent years and a recent clinical evaluation demonstrated disparity in various aspects of device performance. One difference among oxygenators, which to-date has received little attention, was the impact on the patient’s immune cells, with some oxygenators producing a significantly greater increase in immune cell numbers after cross clamp. Such increases in immune cell proliferationmaycontribute to the development of a systemic inflammatory response (SIR), which has been demonstrated to have a negative impact on patient outcomes. Although factors contributing to immune cell proliferation during CPB are recognized to be multi-factorial, the goal of the current communication was to perform an ad hoc analysis of these raw data for evidence that pressure gradients through an oxygenator contributes to this outcome. Despite the observation that higher-pressure gradient oxygenators appeared to associate with increased immune cell proliferation, no correlation was detected in this analysis. This finding, however, provides further evidence for the complex nature of inflammation during CPB, which deserves ongoing discussion and investigation.
Cerebral Oximetry and Autoregulation during Cardiopulmonary Bypass: A Review
Authors: Vranken Nousjka P.A. , Weerwind Patrick W. , Sutedja Nadia A. , Ševerdija Ervin E. , Barenbrug Paul J.C. , Maessen Jos G.
Published: July 2023

Postoperative neurological complications (PNCs) following cardiac surgery with cardiopulmonary bypass (CPB) is a detrimental complication, contributing to increased mortality rates and health care costs. To prevent intraoperative cerebral desaturations associated with PNC, continuous brain monitoring using near-infrared spectroscopy has been advocated. However, clear evidence for a defined desaturation threshold requiring intervention during CPB is still lacking. Since cerebral oximetry readings are nonspecific, cerebral tissue oxygenation values need to be interpreted with caution and in the context of all available clinical information. Therefore, maintaining an intact autoregulatory activity during CPB rather than solely focusing on regional cerebral oxygen saturation measurements will collectively contribute to optimization of patient care during CPB.
The Influence of Intraoperative Autotransfusion on Postoperative Hematocrit after Cardiac Surgery: A Cross-Sectional Study
Authors: Stasko Andrew J. , Stammers Alfred H. , Mongero Linda B. , Tesdahl Eric A. , Weinstein Samuel
Published: July 2023

Utilization of intraoperative autotransfusion (IAT) during cardiac surgery with cardiopulmonary bypass (CPB) has been shown to reduce allogeneic red blood cell transfusion. Previous research has emphasized the benefits of using IAT in the intraoperative period. The present study was designed to evaluate the effects of using IAT on overall hematocrit (Hct) drift between initiation of CPB and the immediate postoperative period. We reviewed 3,225 adult cardiac procedures occurring between February 2016 and January 2017 at 84 hospitals throughout the United States. Data were collected prospectively from adult patients undergoing cardiac surgery with CPB, and stored in the SpecialtyCare Operative Procedural rEgistry (SCOPE), a large quality improvement database. Patients receiving allogeneic transfusion and those with missing covariate data were excluded from analysis. The effect of IAT volume returned to patients on the primary endpoint, hematocrit change from CPB initiation to intensive care unit (ICU) entry, was assessed using a multivariable linear mixed effects regression model controlling for patient demographics, operative characteristics, surgeon, and hospital. Descriptive analysis showed greater positive hematocrit change with increasing autotransfusate volume returned. Those patients with no IAT volume returned saw a median hematocrit change of +2.00%, whereas those with more than 380 mL/m2BSA had a median Hct drift of +5.00% (p< .001). After controlling for known confounds, our regression estimate of the effect of IAT volume returned on Hct drift was +.0045% per 1 mL/m2BSA (p< .001). For a patient with the median autotransfusate volume returned (273 mL/m2BSA), and all other covariate values at their respective medians, this translates to a predicted hematocrit change of +3.6% (95% CI +3.1 to +4.1). These findings lend further support to the notion that autotransfusate volume is positively associated with increases in postoperative hematocrit.
Colloid Oncotic Pressure, Monitoring its Effects in Cardiac Surgery
Authors: Chores Jeffrey B. , Holt David W.
Published: July 2023

Hemodilution is a common perioperative practice. The deleterious effects of excessive hemodilution and subsequent edema formation have been well documented by numerous authors. Colloid oncotic pressure (COP) is a reliable clinical indicator of hemodilution in cardiac surgery. The intent of this study is to determine if a correlation exists between COP and various patient outcome variables. It would also be helpful to know if there is a particular COP value to avoid preventing or limiting patient morbidity. Blood samples from 61 adult patients (mean age = 70 years old) undergoing cardiopulmonary bypass surgery were collected for COP calculation and comparison. Sample collection was performed before heparinization, during cardiopulmonary bypass, at the conclusion of cardiopulmonary bypass, and in the intensive care unit. The resultant values obtained were used to generate a calculated COP. The lowest sustained COP was then compared with various patient outcome variables such as fluid balance, post-operative weight gain, post-operative blood loss, extubation time, length of stay, and blood products administered. A statistically significant difference (p < .05) was found between the COP and each of the monitored continuous variables. The data also suggest that maintaining a patient’s COP at or above 15 mmHg could be desirable. Frequent monitoring of a patient’s COP can provide a potential benefit to clinical decision making.
An In-Vitro Study Comparing the GME Handling of Two Contemporary Oxygenators
Authors: Gisnarian Carl J. , Hedman Angela , Shann Kenneth G.
Published: July 2023

Gaseous microemboli (GME) are a potential complication of cardiopulmonary bypass (CPB). Though it is difficult to prove that GME is the only major cause of neurological deficits, it may increase the chance of post-operative cognitive dysfunction if not removed. The objectives of this research were to compare LivaNova-Sorin Inspire (Inspire) oxygenator with a Medtronic arterial filter to the Medtronic Fusion (Fusion) oxygenator with and without a Medtronic arterial filter based on each system’s ability to handle GME. The Inspire and Fusion systems were evaluated in vitro. GME handling was observed by introducing air in the sampling manifold connected to the venous return at a 60 mL bolus or 1 liter per minute (LPM). The emboli detection and classification (EDAC) system measured GME preand post-oxygenator/arterial filter. The Inspire with a filter was able to remove a statistically significant greater amount of total emboli per second during the 60 mL bolus and 1 LPM tests than the Fusion with and without an arterial filter. The Inspire with an arterial filter was more efficient in removing GME during a 60 mL bolus and 1 LPM than the Fusion and Fusion with an arterial filter. However, the Fusion with an arterial filtered performed better than the Fusion system without the arterial filter.
Synthetic Approaches to the 2019–2020 New Agrochemicals
Authors: Lamberth Clemens , Jeanmart Stephane , Edmunds Andrew J. F. , Pouliot Martin , Morris James A.
Published: July 2023

This review outlines the synthesis of the ten novel agrochemicals that received an International Standardization Organization (ISO) common name during 2019 and 2020. These agrochemicals will be used to control a wide range of weeds, insects and plant pathogens and their syntheses represent significant advances in the field of crop protection. The broad variety of different reactions, reagents and intermediates used to discover and produce this latest generation of agrochemicials is impressive.

1 Introduction

2 Fungicides and Virucides

3 Herbicides

4 Insecticides, Acaricides and Nematicides

5 Conclusion
Comparison of Outcomes of Less Invasive Surfactant Administration in Prematurely Born Infants in the Delivery Suite and the Neonatal Unit
Authors: Shetty Sandeep , Tolentino Donna , Kulkarni Anay , Duffy Donovan , Greenough Anne
Published: July 2023

Objective This study aimed to compare outcomes of infants who received less invasive surfactant administration (LISA) in the delivery suite (LISA-DS) with those who received LISA on the neonatal unit (LISA-NNU).

Study Design A prospective cohort study was undertaken of all infants who received LISA in a single center. Clinical outcomes included admission temperature, the need for intubation, durations of invasive and noninvasive ventilation, length of hospital stay and the incidences of bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and requirement for home oxygen were compared between the two groups as were complications of the procedure.

Results The 54 LISA-DS infants had similar gestational ages and birth weights to the 26 LISA-NNU infants (p = 0.732, 0.928, respectively). There were no significant differences between the admission temperatures (median [range]: 36.8 [36–38.7] vs. 36.8°C [36.4–37.7]; p = 0.451) or need for intubation in less than 72 hours of birth (28 vs. 23%, p = 0.656). The durations of invasive ventilation (median: 2 [0–65] vs. 1 [0–35] days; p = 0.188) and noninvasive ventilation (median: 37 [24–81] vs. 37 [3–225] days; p = 0.188) and the incidences of BPD (p = 0.818), IVH (p = 0.106), ROP (p = 0.526), and home oxygen requirement (p = 0.764) were similar. The percentage of successful first attempts with LISA (63 vs. 70%, p = 0.816) or associated with hypoxia episodes (32 vs. 42%, p = 0.194) did not differ significantly by site of administration.

Conclusion The outcomes of LISA performed on the DS were similar to those of LISA performed on the NNU.

Key Points
Fado, urban popular song, and intangible heritage: perceptions of authenticity and emotions in TripAdvisor reviews
Authors: Carvalho Inês , Madeira Arlindo , Monteiro Anabela , Lopes Sofia , Palrão Teresa
Published: July 2023

Intangible cultural heritage, such as music, often becomes the symbol of urban spaces. One example is fado, a music genre that originated in Lisbon, Portugal. With the increasing prominence of fado as a cultural heritage, an increasing number of tourists are attracted to fado shows. In this context, this study seeks to answer the following research question: “How do emotion and authenticity relate to visitors’ overall satisfaction in fado venues?”. Based on mixed methods research (descriptive statistics, inferential statistics, and content analysis), 2653 TripAdvisor reviews of four fado venues in Lisbon were analyzed. We conclude that although both authenticity and emotion are highly associated with overall satisfaction, lack of authenticity was not markedly associated with dissatisfaction. The most recent fado house is perceived as the most authentic one.
Chimera states in a large laterally coupled laser array with four different waveguide structures
Authors: Gu Shuangquan , Fang Qi , Zhou Pei , Li Nianqiang
Published: July 2023

Chimera states are rich and fascinating phenomena existing in many networks, where the identical oscillators self-organize into spatially separated coexisting domains of coherent and incoherent oscillations. Here, we report these states in the large laterally coupled laser array with four different waveguiding structures, with which a variety of chimera patterns can be revealed. We present the bifurcation diagrams giving birth to them and find that the chimeras exist in the boundary of the steady state and multi-period oscillation solutions, which applies to all the prevalent waveguiding structures considered. We also find that the waveguiding structures play an important role in the chimera states, e.g., the array composed of the index antiguiding with gain-guiding has a wider chimera region compared to other waveguides considered. Additionally, the effects of the crucial parameters including the laser separation ratio, pump rate, frequency detuning, and linewidth enhancement factor on the observed phenomena are discussed. Our analysis shows that the frequency detuning between lasers and the linewidth enhancement factor affects the lifetime and pattern of chimeras. The results could guide the design of laser arrays or introduce more insight into a new understanding of the dynamical behaviors of networks.
EUV debris mitigation using magnetic nulls
Authors: Israeli B. Y. , Smiet C. B. , Simeni Simeni M. , Diallo A.
Published: July 2023

Next generation EUV sources for photolithography use light produced by laser-produced plasmas (LPP) from ablated tin droplets. A major challenge for extending the lifetime of these devices is mitigating damage caused by deposition of tin debris on the sensitive collection mirror. Especially difficult to stop are high energy (up to 10 keV) highly charged tin ions created in the plasma. Existing solutions include the use of stopping gas, electric fields, and magnetic fields. One common configuration consists of a magnetic field perpendicular to the EUV emission direction, but such a system can result in ion populations that are trapped rather than removed. We investigate a previously unconsidered mitigation geometry consisting of a magnetic null by performing full-orbit integration of the ion trajectories in an EUV system with realistic dimensions and optimize the coil locations for the null configuration. The magnetic null prevents a fraction of ions from hitting the mirror comparable to that of the perpendicular field, but does not trap any ions due to the chaotic nature of ion trajectories that pass close to the null. This technology can potentially improve LPP-based EUV photolithography system efficiency and lifetime and may allow for a different, more efficient formulation of buffer gas.
Molecular dynamics study on the interfacial properties of mixtures of monomers of polyvinylpyrrolidone (PVP)-based battery binders on graphene and graphite surfaces
Authors: Gutiérrez Alberto , Aparicio Santiago , Pekarovicova Alexandra , Wu Qingliu , Atilhan Mert
Published: July 2023

This study investigates the behavior of two different mixtures of monomers of polyvinylpyrrolidone (PVP)-based battery binders, polyvinylpyrrolidone:polyvinylidene difluoride (PVP:PVDF) and polyvinylpyrrolidone:polyacrylic acid (PVP:PAA), at graphene and graphite interfaces using classical molecular dynamics simulations. The aim is to identify the best performing monomer binder blend and carbon-based material for the design of battery-optimized energy devices. The PVP:PAA monomer binder blend and graphite are found to have the best interaction energies, densification upon adsorption, and more ordered structure. The adsorption of both monomer binder blends is strongly guided by the higher affinity of PVP and PAA monomeric molecules for the surfaces compared to PVDF. The structure of adsorbed layers of PVP:PVDF monomer binder blend on graphene and graphite develops more quickly than PVP:PAA, indicating faster kinetics. This study complements a previous density functional theory study recently reported by our group and contributes to a better understanding of the nanoscopic features of relevant interfacial regions involving mixtures of monomers of PVP-based battery binders and different carbon-based materials. The effect of a blend of commonly used monomer binders on carbon-based materials is essential for obtaining tightly bound anode and cathode active materials in lithium-ion batteries, which is crucial for designing battery-optimized energy devices.
A physics investigation on impedance matching theory in microwave absorption film—Part I. Theory
Authors: Liu Ying , Drew Michael G. B. , Liu Yue
Published: July 2023

The mechanism for microwave absorption in a film has previously been numerically verified from the theoretical formula for RL and attributed to angular and amplitude effects with a simple geometrical representation from energy conservation unique to the film. Starting from the case where |RL| = 0, using basic transmission-line theory and mathematics, it is confirmed theoretically here that the mechanism for absorption mechanism in a film, responsible for the minima of the reflection loss RL/dB, is best explained by wave cancelation theory rather than by impedance matching theory. This theoretical proof also reveals that the mechanisms for a film and material are different. The flaws of neglecting the phase effects of interfaces in a film in quarter-wavelength theory are also quantitatively discussed from transmission-line theory. Contrary to the theory held currently, the reported minima of RL/dB originate from phase effects in the film rather than from the resonance peaks for the intrinsic frequencies of a material.
Analyzing the buckling of FGCNT-reinforced sandwich microshells in heart pacemakers: The impact of thickness stretching on third-order shear deformation
Authors: Mohammed Layth , Biglari Hasan , Vakili-Tahami Farid
Published: July 2023

This study focuses on the buckling behavior of composite microshells inside pacemakers to select the most durable material. Due to the strong electromagnetic forces encountered by pacemaker microshells, comprehensive research is needed to identify suitable materials. This study analyzes the buckling behavior of a porous sandwich cylindrical microshell attached to electrodes, which is supported by an elastic foundation and reinforced with functionally graded carbon nanotubes. Three porosity models are considered for the core material, and the equilibrium equations are derived using Hamilton’s principle based on third order shear deformation theory. This study compares the critical buckling loads with those from the literature and examines the effects of various parameters, such as thickness stretching and non-stretching. The findings indicate that the thickness stretching effect has a significant influence on the critical buckling load. In addition, a lower functionally graded power index and higher porosity volume fraction result in higher critical buckling loads. These results are relevant for micro-electromechanical systems and can aid in the selection of appropriate materials for pacemaker microshells to improve their durability and performance.
Deep reservoir computing based on self-rectifying memristor synapse for time series prediction
Authors: Wang Rui , Liang Qi , Wang Saisai , Cao Yaxiong , Ma Xiaohua , Wang Hong , Hao Yue
Published: July 2023

Herein, a self-rectifying resistive switching memristor synapse with a Ta/NbOx/Pt structure was demonstrated for deep reservoir computing (RC). The memristor demonstrated stable nonlinear analog switching characteristics, with a rectification ratio of up to 1.6 × 105, good endurance, and high uniformity. Additionally, the memristor exhibited typical short-term plasticity and dynamic synaptic characteristics. Based on these characteristics, a deep memristor RC system was proposed for time series prediction. The system achieved a low normalized root mean square error (NRMSE) of 0.04 in the time series prediction of the Henon map. Even at 90 °C, deep RC retains good predictive power with an NRMSE of only 0.07. This work provides guidance for efficient deep memristive RC networks to handle more complex future temporal tasks.
Demonstration of thermal limit mean transverse energy from cesium antimonide photocathodes
Authors: Kachwala Alimohammed , Saha Pallavi , Bhattacharyya Priyadarshini , Montgomery Eric , Chubenko Oksana , Karkare Siddharth
Published: July 2023

The mean transverse energy (MTE) of electrons emitted from cathodes is a critical parameter that determines the brightness of electron beams for applications, such as x-ray free electron lasers, particle colliders, and ultrafast electron scattering experiments. Achieving a MTE close to the thermal limit is a key step toward realizing the full potential of electron sources in these applications. Cesium antimonide (Cs3Sb) is a technologically important material with a long history of use in photon detection and electron sources. The smallest MTE of electrons photoemitted from Cs3Sb has always been appreciably greater than the thermal limit and was attributed to surface non-uniformities. In this work, we present comprehensive measurements of the photoemission electron energy spectra (PEES), quantum efficiency, and MTE from Cs3Sb in a wide photoexcitation energy range from 1.5 to 2.3 eV. Our PEES measurements demonstrate a notably low photoemission threshold of around 1.5 eV, which is in contrast with the previously perceived threshold of 1.8–2.0 eV. Moreover, we show that the MTE at this threshold of 1.5 eV nearly converges to the thermal limit at 300 K. At 1.8 eV, the MTE measured is 40 meV, which is comparable to the previously reported value. We conclude that this MTE value at 1.8 eV photon energy is not due to surface roughness effects as previously believed, but is a direct consequence of the excess energy.
Applied semantics and climate communication
Authors: Bromhead Helen , Goddard Cliff
Published: July 2023

This paper explores ways in which applied semantics (coming out of Natural Semantic Metalanguage approach) can inform effective communicative strategies for action on climate change. After framing discussion, it presents three case studies, which are intentionally disparate in nature: contrastive semantics of the expressions ‘climate crisis’, ‘climate emergency’, and ‘climate catastrophe’; a semantically-enhanced examination of how public inquiries into extreme weather events help shape climate discourse in Australia; the semantics of ‘the economy’ in everyday English and the implications for climate change discourse. We argue that climate action communication is clearer, more resonant, and more effective when it uses or builds on ordinary words and local meanings.
Questions for Translation Studies
Authors: Robinson Douglas
Published: July 2023

This is a book in the classical Quaestiones genre, like the Tusculanae Quaestiones (“Tusculan questions”) of Cicero (around 45 BCE) and the Quæstiones disputatæ de Veritate (“disputed questions on truth”) of St. Thomas Aquinas (1256-1259). It seeks to ask seven series of questions about key theoretical approaches to the study of translation: three on equivalence theories (semantic equivalence, dynamic equivalence, and deverbalization), three on Descriptive Translation Studies (norms, Toury’s laws, and the translator’s narratoriality), and one on the translator’s visibility. Each “Question” (chapter) charts a circuitous course through past answers to new questions and new answers, drawing especially on the theoretical traditions of hermeneutics, phenomenology, and 4EA cognitive science. The book will guide both veteran and novice scholars of translation deep into the complexities besetting the seven keywords.
Lived experiences of coloniality in third space
Authors: Tavares Bernardino , Vieira Aleida
Published: July 2023

This paper discusses the interactions of the so-called lusophone migrants in ‘third space’ (Bhabha, 1994) i.e., outside the Portuguese geographical colonial matrix. Part of a larger project interested in studying whether new solidarities or old hierarchies replay when all lusophones meet and struggle in a new context, the paper examines traces of whatMignolo (2005)has termed of ‘coloniality of being’ i.e., everyday remnants of colonial modes and hierarchies. It draws from postcolonial theory and sociolinguistic ethnography to examine how coloniality perdures in intersubjective relations among lusophones, by exploring the narrative of two Cape Verdean retirees who (re)migrated to Luxembourg in 1971 and 1981. The paper uses narrative analysis to examine how they report coloniality in lusophone interactions being challenged or perpetuated at workplaces and social encounters, via stereotyping jokes, naming, and language use. It fosters a critical understanding of lusophone subjects’ interactions, marked by language and their colonial history, beyond Portuguese-speaking states.
On the manifestness of assumptions
Authors: Maillat Didier
Published: July 2023

Right from the outset, relevance theory (Sperber and Wilson 1986/1995) tried to define interpretation as a process of context elaboration. Interpretation is seen as a path of least effort leading to the selection of a set of most accessible assumptions. One of the central aspects of this context elaboration process lies in the fact that contextual assumptions are not randomly scattered in the hearer’s cognitive environment. Instead, relevance theory claims that there are some organising principles ordering contextual assumptions and determining which will be accessed first and, therefore, which will be retained as part of the optimally relevant interpretation.

The main organising principle is captured by the notion of manifestness, which combines two distinct properties of contextual assumptions: their accessibility and their strength in the cognitive environment. Sperber and Wilson (1986/1995) define them as a function of the processing history of an assumption for the former and the confidence with which an assumption is held for the latter.

In this paper, I will explore the explanatory potential of manifestness by putting the notions of strength and accessibility to work on two current trends in pragmatic research, namely commitment (Ifantidou 2001; Boulat and Maillat 2017, 2023; Mazzarella et al. 2018; Bonalumi et al. 2020) and emotion (Moeschler 2009; Dezecache et al. 2013, 2015; Wharton and Strey 2019; Wilson and Carston 2019; Saussure and Wharton 2020; Wharton et al. 2021). My goal will be to show how these two dimensions of manifestness, as they were developed in the very early days of RT, can provide us with new theoretical insights in the study of human communication. In this paper, I will argue that, beyond their usefulness in providing a guiding principle for the comprehension procedure, the strength and accessibility of contextual assumptions can also advantageously shed light on other phenomena like commitment and emotions.
Phase transitions in the driven lattice gas (TASEP) with repulsive energies
Authors: Baumgaertner A , Narasimhan S L
Published: July 2023

We report on non-equilibrium phase transitions in the driven lattice gas model totally asymmetric exclusion processes caused by nearest-neighbor (NN) repulsions between particles,ɛ > 0, employing extensive Monte Carlo simulations and mean-field calculations. The diagra of phase regimes has five different regimes which are separated by distinct boundaries. We discuss the density of particles and the current which depend differently in the various regimes on the system’s entry and exit rates of particles,αandβ, respectively. The steady state can be described by quasi-particles called ‘soft dimerons’, where each dimeron consists of a particle dragging an empty NN site on its left. The asymptotic state of dimerons atε→∞is equivalent to the state of hard dimers atɛ = 0. Since the model is a uni-directional fluid, it has an internal hydrodynamic pressure which increases with increasing inter-particle repulsionɛ. This leads to a collective effect which causes phase transitions between high and low densities of particles at certain critical pointsɛc.
A guided light system for agile individual addressing of Ba+ qubits with 10−4 level intensity crosstalk
Authors: Binai-Motlagh Ali , L Day Matthew , Videnov Nikolay , Greenberg Noah , Senko Crystal , Islam Rajibul
Published: July 2023

Trapped ions are one of the leading platforms for quantum information processing, exhibiting the highest gate and measurement fidelities of all contending hardware. In order to realize a universal quantum computer with trapped ions, independent and parallel control over the state of each qubit is necessary. The manipulation of individual qubit states in an ion chain via stimulated Raman transitions generally requires light focused on individual ions. In this manuscript, we present a novel, guided-light individual addressing system for hyperfine Ba+ qubits. The system takes advantage of laser-written waveguide technology, enabled by the atomic structure of Ba+, allowing the use of visible light to drive Raman transitions. Such waveguides define the spatial mode of light, suppressing aberrations that would have otherwise accumulated in a free-space optics set up. As a result, we demonstrate a nearest neighbor relative intensity crosstalk on the order of 10−4, without any active aberration compensation. This is comparable to or better than other previous demonstrations of individual addressing. At the same time, our modular approach provides independent and agile control over the amplitude, frequency, and phase of each channel; combining the strengths of previous implementations.
Influence of surface effect on post-buckling behavior of piezoelectric nanobeams
Authors: Yang Fan , Song Xianlai , Wang Xuyang , Chen Zengtao , Yang Weilin
Published: July 2023

Piezoelectric nanobeams with excellent mechanical, thermal and electrical properties are important components in micro-nano electromechanical systems, which are widely used as sensors, brakes and resonators. Based on the Euler–Bernoulli beam model, the influence of surface effect on the post-buckling behaviour of piezoelectric nanobeams is analysed. According to the surface elasticity theory and the ‘core–shell’ model, the surface energy model is used to introduce the influence of surface effect. The governing equations and boundary conditions of the post-buckling of piezoelectric nanobeams under the influence of surface effect are derived by the principle of minimum potential energy. The analytical solution of post-buckling is obtained by the eigenvalue method. The influence of surface effect on the post-buckling configuration, post-buckling path, amount of induced charge and critical load of piezoelectric nanobeams with different external constraints and cross-sectional dimensions are discussed. The results show that surface effect has a significant influence on the post-buckling of piezoelectric nanobeams. Considering surface effect, the effective elastic modulus and critical load of piezoelectric nanobeams are increased, and the post-buckling configuration, post-buckling path and amount of induced charge are reduced. These findings contribute to the study of micro-nano electromechanical systems based on nanobeam structures and provide a theoretical basis for the design and manufacture of nanodevices.
A biology-driven deep generative model for cell-type annotation in cytometry
Authors: Blampey Quentin , Bercovici Nadège , Dutertre Charles-Antoine , Pic Isabelle , Ribeiro Joana Mourato , André Fabrice , Cournède Paul-Henry
Published: July 2023

Cytometry enables precise single-cell phenotyping within heterogeneous populations. These cell types are traditionally annotated via manual gating, but this method lacks reproducibility and sensitivity to batch effect. Also, the most recent cytometers—spectral flow or mass cytometers—create rich and high-dimensional data whose analysis via manual gating becomes challenging and time-consuming. To tackle these limitations, we introduce Scyan https://github.com/MICS-Lab/scyan, a Single-cell Cytometry Annotation Network that automatically annotates cell types using only prior expert knowledge about the cytometry panel. For this, it uses a normalizing flow—a type of deep generative model—that maps protein expressions into a biologically relevant latent space. We demonstrate that Scyan significantly outperforms the related state-of-the-art models on multiple public datasets while being faster and interpretable. In addition, Scyan overcomes several complementary tasks, such as batch-effect correction, debarcoding and population discovery. Overall, this model accelerates and eases cell population characterization, quantification and discovery in cytometry.
Covariate-adjusted log-rank test: guaranteed efficiency gain and universal applicability
Authors: Ye Ting , Shao Jun , Yi Yanyao
Published: July 2023

Nonparametric covariate adjustment is considered for log-rank-type tests of the treatment effect with right-censored time-to-event data from clinical trials applying covariate-adaptive randomization. Our proposed covariate-adjusted log-rank test has a simple explicit formula and a guaranteed efficiency gain over the unadjusted test. We also show that our proposed test achieves universal applicability in the sense that the same formula of test can be universally applied to simple randomization and all commonly used covariate-adaptive randomization schemes such as the stratified permuted block and the Pocock–Simon minimization, which is not a property enjoyed by the unadjusted log-rank test. Our method is supported by novel asymptotic theory and empirical results for Type-I error and power of tests.
Secukinumab for Netherton syndrome: a Malaysian experience
Authors: Ting Ingrid Pao Lin , Lee Tyan Shin , Teo Hock Gin , Albela Henrietta , Tang Min Moon , Leong Kin Fon
Published: July 2023

We described three patients with Netherton syndrome in Malaysia treated with secukinumab with variable outcomes. To date, there have only been reports of about eight patients being treated with secukinumab globally with this condition, with good outcomes. We hope our observation will add to the existing global pool of information about Netherton syndrome treated with secukinumab.
Defining Magnetic Resonance Imaging Treatment Response and Remission in Crohn’s Disease: A Systematic Review
Authors: Caron Bénédicte , Jairath Vipul , Laurent Valérie , Stoker Jaap , Laghi Andrea , D’Haens Geert R , Danese Silvio , Peyrin-Biroulet Laurent
Published: July 2023

Background

Magnetic resonance imaging is increasingly used to assess treatment response in Crohn’s disease clinical trials. We aimed to describe the definition of MRI response and remission as assessed by magnetic resonance enterography [MRE] to evaluate treatment efficacy in these patients.

Methods

Electronic databases were searched up to May 1, 2023. All published studies enrolling patients with inflammatory bowel disease and assessment of treatment efficacy with MRE were eligible for inclusion.

Results

Eighteen studies were included. All studies were performed in patients with Crohn’s disease. The study period ranged from 2008 to 2023. The majority of studies used endoscopy as the reference standard [61.1%]. MRE response was defined in 11 studies [61.1%]. Five scores and nine different definitions were proposed for MRE response. MRE remission was defined in 12 studies [66.7%]. Three scores and nine different definitions for MRE remission were described. The MaRIA score was the most frequent index used to evaluate MRE response [63.6%] and remission [41.7%]. MRE response was defined as MaRIA score <11 in 63.6% of studies using this index. In 60% of studies using the MaRIA score, MRE remission was defined as MaRIA score <7. In addition, 11 different time points of assessment were reported, ranging from 6 weeks to years.

Conclusion

In this systematic review, significant heterogeneity in the definition of MRE response and remission evaluated in patients with Crohn’s disease was observed. Harmonization of eligibility and outcome criteria for MRE in Crohn’s Disease clinical trials is needed.
Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn’s Disease and Interact with Regulatory Variants for TAP2
Authors: Kim Kwangwoo , Oh Shin Ju , Lee Junho , Kwon Ayeong , Yu Chae-Yeon , Kim Sangsoo , Choi Chang Hwan , Kang Sang-Bum , Kim Tae Oh , Park Dong Il , Lee Chang Kyun
Published: July 2023

Background and Aims

Crohn’s disease [CD] has a complex polygenic aetiology with high heritability. There is ongoing effort to identify novel variants associated with susceptibility to CD through a genome-wide association study [GWAS] in large Korean populations.

Methods

Genome-wide variant data from 902 Korean patients with CD and 72 179 controls were used to assess the genetic associations in a meta-analysis with previous Korean GWAS results from 1621 patients with CD and 4419 controls. Epistatic interactions between CD-risk variants of interest were tested using a multivariate logistic regression model with an interaction term.

Results

We identified two novel genetic associations with the risk of CD near ZBTB38 and within the leukocyte immunoglobulin-like receptor [LILR] gene cluster [p < 5 × 10−8], with highly consistent effect sizes between the two independent Korean cohorts. CD-risk variants in the LILR locus are known quantitative trait loci [QTL] for multiple LILR genes, of which LILRB2 directly interacts with various ligands including MHC class I molecules. The LILR lead variant exhibited a significant epistatic interaction with CD-associated regulatory variants for TAP2 involved in the antigen presentation of MHC class I molecules [p = 4.11 × 10−4], showing higher CD-risk effects of the TAP2 variant in individuals carrying more risk alleles of the LILR lead variant (odds ratio [OR] = 0.941, p = 0.686 in non-carriers; OR = 1.45, p = 2.51 × 10−4 in single-copy carriers; OR = 2.38, p = 2.76 × 10−6 in two-copy carriers).

Conclusions

This study demonstrated that genetic variants at two novel susceptibility loci and the epistatic interaction between variants in LILR and TAP2 loci confer a risk of CD.
An augmented reality–based method to assess precordial electrocardiogram leads: a feasibility trial
Authors: Serfözö Peter Daniel , Sandkühler Robin , Blümke Bibiana , Matthisson Emil , Meier Jana , Odermatt Jolein , Badertscher Patrick , Sticherling Christian , Strebel Ivo , Cattin Philippe C , Eckstein Jens
Published: July 2023

Aims

It has been demonstrated that several cardiac pathologies, including myocardial ischaemia, can be detected using smartwatch electrocardiograms (ECGs). Correct placement of bipolar chest leads remains a major challenge in the outpatient population.

Methods and results

In this feasibility trial, we propose an augmented reality–based smartphone app that guides the user to place the smartwatch in predefined positions on the chest using the front camera of a smartphone. A machine-learning model using MobileNet_v2 as the backbone was trained to detect the bipolar lead positions V1–V6 and visually project them onto the user’s chest. Following the smartwatch recordings, a conventional 10 s, 12-lead ECG was recorded for comparison purposes. All 50 patients participating in the study were able to conduct a 9-lead smartwatch ECG using the app and assistance from the study team. Twelve patients were able to record all the limb and chest leads using the app without additional support. Bipolar chest leads recorded with smartwatch ECGs were assigned to standard unipolar Wilson leads by blinded cardiologists based on visual characteristics. In every lead, at least 86% of the ECGs were assigned correctly, indicating the remarkable similarity of the smartwatch to standard ECG recordings.

Conclusion

We have introduced an augmented reality–based method to independently record multichannel smartwatch ECGs in an outpatient setting.
Confounding adjustment in observational studies on cardiothoracic interventions: a systematic review of methodological practice
Authors: Velders Bart J J , Boltje J W Taco , Vriesendorp Michiel D , Klautz Robert J M , Le Cessie Saskia , Groenwold Rolf H H
Published: July 2023

OBJECTIVES

It is unknown which confounding adjustment methods are currently used in the field of cardiothoracic surgery and whether these are appropriately applied. The aim of this study was to systematically evaluate the quality of conduct and reporting of confounding adjustment methods in observational studies on cardiothoracic interventions.

METHODS

A systematic review was performed, which included all observational studies that compared different interventions and were published between 1 January and 1 July 2022, in 3 European and American cardiothoracic surgery journals. Detailed information on confounding adjustment methods was extracted and subsequently described.

RESULTS

Ninety-two articles were included in the analysis. Outcome regression (n = 49, 53%) and propensity score (PS) matching (n = 44, 48%) were most popular (sometimes used in combination), whereas 11 (12%) studies applied no method at all. The way of selecting confounders was not reported in 42 (46%) of the studies, solely based on previous literature or clinical knowledge in 14 (16%), and (partly) data-driven in 25 (27%). For the studies that applied PS matching, the matched cohorts comprised on average 46% of the entire study population (range 9–82%).

CONCLUSIONS

Current reporting of confounding adjustment methods is insufficient in a large part of observational studies on cardiothoracic interventions, which makes quality judgement difficult. Appropriate application of confounding adjustment methods is crucial for causal inference on optimal treatment strategies for clinical practice. Reporting on these methods is an important aspect of this, which can be improved.
Does orthodontic treatment improve the Oral Health-Related Quality of Life when assessed using the Malocclusion Impact Questionnaire—a 3-year prospective longitudinal cohort study
Authors: Peter Elbe , Monisha J , Edward Benson Philip , Ani George Suja
Published: July 2023

Objectives

To assess the change in Oral Health-Related Quality of Life (OHRQoL) following orthodontic treatment using the Malocclusion Impact Questionnaire (MIQ) and to test the responsiveness of MIQ to treatment-associated changes.

Methods

A longitudinal prospective cohort study, in an orthodontic postgraduate centre, Kerala, India. Patients under 18 years were invited to complete the MIQ before the start of treatment (T0) and 1 month after treatment completion (T1). TheIndex of Orthodontic Treatment Need and Peer Assessment Rating (PAR) scores were assessed at both time periods as well as a global transition judgement at T1.

Results

Two hundred and ten participants were recruited and 162 completed both questionnaires (45.1% males; 54.9% females; age = 12–18 years, mean = 16.8; SD = 1.7). There was large reduction in MIQ scores from T0 (mean = 28.1, SD = 6.1) to T1 (mean = 3.7, SD = 2.6). 53% reported a large improvement in oral health and related life quality after treatment, 32% minimal change, and 15% no change. None reported worsening in OHRQoL at T1. There was a significant positive correlation between change in MIQ score and change in PAR score (r = 0.358), pretreatment aesthetic component (rho = 0.467) and dental health component (rho = 0.491) of the index of orthodontic treatment (IOTN-DHC), and treatment time (rho = 0.502). Regression analysis revealed the change in PAR score and pretreatment IOTN-DHC to be independent predictors of change in MIQ score. Standardized effect size (4.0) and standardized response mean (2.9) were large and the minimal important difference was 7.7. Receiver operating characteristic analysis reported a high diagnostic accuracy of MIQ.

Conclusions

There was a significant improvement in OHRQoL following orthodontic treatment when assessed using a condition-specific measure for malocclusion. MIQ was found to be responsive to changes associated with orthodontic treatment.
Psychosocial adaptation profiles in young and middle-aged patients with acute myocardial infarction: a latent profile analysis
Authors: Xiong Jia-ming , Su Jin , Ke Qi-qi , Li Yao-xia , Gong Ni , Yang Qiao-hong
Published: July 2023

Aims

We sought to explore the latent classifications of psychosocial adaptation in young and middle-aged patients with acute myocardial infarction (AMI) and analyse the characteristics of different profiles of AMI patients.

Methods and results

A cross-sectional study was performed in 438 Chinese young and middle-aged patients with AMI. The investigation time was 1 month after discharge. Three different self-report instruments were distributed to the participants, including the Psychosocial Adjustment to Illness Scale, the Perceived Stress Scale, and the Social Support Rating Scale. The seven dimensions of the Psychosocial Adjustment to Illness Scale were then used to perform a latent profile analysis. All participants signed informed consent forms in accordance with the ethical principles of the Declaration of Helsinki. Finally, a total of 411 young and middle-aged AMI patients were enrolled. Three distinct profiles were identified, including the ‘well-adapted group’ (44.8%), ‘highlight in psychological burdens group’ (25.5%), and ‘poorly adapted group’ (29.7%). The influencing factors included stress perception, social support, occupational type, and marital status (P < 0.05).

Conclusion

The psychosocial adaptation of young and middle-aged AMI patients can be divided into three profiles. Clinical nurses can carry out individualized psychological interventions according to the characteristics of patients in different potential profiles to improve the psychosocial adaptation of patients and the prognosis of their disease.
Occupational radiation exposure of electrophysiology staff with reproductive potential and during pregnancy: an EHRA survey
Authors: Adeliño Raquel , Malaczynska-Rajpold Katarzyna , Perrotta Laura , Manninger Martin , Vanduynhoven Philippe , Nesti Martina , Goanță Emilia-Violeta , Waldmann Victor , Pavlovic Nikola , Farkowski Michal M , Guerra Jose M , Penela Diego , Boveda Serge , Chun Julian K R
Published: July 2023

Aims

Electrophysiology (EP) is a growing field in cardiology, with an increasing involvement of young people. Nevertheless, concerns about radiation exposure and its impact on reproduction and pregnancy may discourage the choice of an EP career. The study is aimed at investigating the level of awareness and main sources of concern about the effects of radiation on reproductive potential and pregnancy, exploring the safety measures adopted in different EP labs, and verifying the adherence to the current guidelines.

Methods and results

An online survey was conducted using the European Heart Rhythm Association (EHRA) infrastructure from April to June 2022. A total of 252 EP personnel (42% women) participated, from 50 countries and different professional roles. Most participants expressed concerns regarding the effects of radiation on reproductive capacity (67.1%) and offspring diseases (68.2%). Only 37.9% of participants were aware of the EHRA 2017 consensus document about occupational radiation exposure. Most participants (80.9%) considered that occupational radiation during pregnancy is not safe. EP female staff were not allowed to work in the EP lab during pregnancy in 48.1% of cases. Zero-fluoroscopy was the preferred choice to continue working in the EP lab during pregnancy.

Conclusion

EP staff, including both men and women, have concerns about the effects of radiation on reproductive capacity. Despite the recommendations issued by international bodies, implementation of the policies regarding pregnancy and occupational radiation exposure is heterogeneous. Zero-fluoroscopy is the preferred approach to ensure safety during pregnancy in the EP lab.