bluuebunny/crossref_metadata_2025 huggingface dataset:
Management Considerations for Patients With Primary Refractory and Early Relapsed Diffuse Large B-Cell Lymphoma
Authors: Duarte Cassandra , Kamdar Manali
Published: April 2023

Most patients with diffuse large B-cell lymphoma (DLBCL) will be cured with up-front chemoimmunotherapy, but 30%-40% of patients will experience relapsed disease. Historically, salvage chemotherapy followed by autologous stem-cell transplant (ASCT) was the mainstay of treatment for these patients. However, research has demonstrated that patients with primary refractory or early relapsed (R/R; high-risk) DLBCL do not benefit from ASCT, prompting investigation into other options. With the advent of chimeric antigen receptor (CAR) T-cell therapy, treatment of R/R DLBCL has changed dramatically. With positive outcomes in the TRANSFORM and ZUMA-7 trials with manageable toxicity profiles, approval was obtained for lisocabtagene maraleucel (liso-cel) and axicabtagene ciloleucel (axi-cel) as second-line therapies for high-risk R/R DLBCL. However, these trials required patients to be medically fit for ASCT. In PILOT, liso-cel was deemed a reasonable treatment option for R/R transplant-ineligible patients. We recommend either axi-cel or liso-cel for fit patients with high-risk R/R DLBCL or liso-cel for unfit R/R patients as a second-line therapy. If CAR T-cell therapy is not an option, we recommend consideration of either ASCT if the patient has chemosensitive disease and is fit or clinical trial if the patient is unfit or has chemoresistant disease. If trials are not an option, alternative treatments are available. With the advent of additional therapies such as bispecific T-cell–engaging antibodies, the treatment landscape of R/R DLBCL may be upended. There continue to be many unanswered questions in the management of patients with R/R DLBCL, but given the promise of cellular therapies, outcomes are more optimistic in this group with historically dismal survival.
Child of the Cranes
Authors: Bennett Steffani
Published: April 2023

The monk-painter Sesshū Tōyō (1420–ca. 1506) is among the most heralded of Japanese artists. This reputation is due in large part to his heroization in art-historical texts of the early modern period. Earlier scholarly emphasis on Sesshū's artistic individualism has obscured our understanding of the professional nature of his activity as a painter in service to a regional military clan. This article reexamines Sesshū's career through consideration of the pair of folding screens known as Birds and Flowers of the Four Seasons. As the only firmly attributed painting in this format in the painter's oeuvre, Birds and Flowers offers illuminating insight into the ways in which Sesshū performed the role of painter-in-attendance for the Ōuchi clan. Sesshū's travel to China as part of an official diplomatic delegation in the fifteenth century was the most defining experience of the painter's career. In style and subject matter, Birds and Flowers provides insight into Sesshū's encounter with imperial painting at the Ming academy during this time. This symbolic analysis also offers a fresh approach to deciphering the heretofore mysterious patronage context surrounding the screens.
Rescaling Falconer's The Shipwreck: Time, Labor, and the Problem of Immersion
Authors: Edson Michael
Published: April 2023

Reading, like sailing, is a durational experience: reading takes place in time and, if a poem is lengthy enough, reading can thwart absorption and make one notice time passing. Reading time therefore offered William Falconer in The Shipwreck (1762) an overlooked resource for tactfully impressing on non-sailors in his readership what is perhaps the central experience of sea travel in the sailing age: the dull passage of vast stretches of time against an unvaried backdrop of sea and sky. This essay considers how Falconer narrativizes the voyage in his poem and balances the competing demands of truthfully conveying the sailors’ experience, including the vast timescales of sea travel, with the engaging of nonspecialists uninterested in the narration of uneventful voyage durations. Close attention to the later authorial editions shows Falconer expanding his descriptions, adding epic similes, and relocating episodes in ways that reveal an effort to make readers view reading time as a proxy experience for voyage time.
The current role of nuclear medicine in breast cancer
Authors: Vaz Sofia C. , Oliveira Carla , Teixeira Ricardo , Arias-Bouda Lenka M. Pereira , Cardoso Maria João , de Geus-Oei Lioe-Fee
Published: April 2023

Breast cancer is the most common cancer in females worldwide. Nuclear medicine plays an important role in patient management, not only in initial staging, but also during follow-up. Radiopharmaceuticals to study breast cancer have been used for over 50 years, and several of these are still used in clinical practice, according to the most recent guideline recommendations.

In this critical review, an overview of nuclear medicine procedures used during the last decades is presented. Current clinical indications of each of the conventional nuclear medicine and PET/CT examinations are the focus of this review, and are objectively provided. Radionuclide therapies are also referred, mainly summarising the methods to palliate metastatic bone pain. Finally, recent developments and future perspectives in the field of nuclear medicine are discussed. In this context, the promising potential of new radiopharmaceuticals not only for diagnosis, but also for therapy, and the use of quantitative imaging features as potential biomarkers, are addressed.

Despite the long way nuclear medicine has gone through, it looks like it will continue to benefit clinical practice, paving the way to improve healthcare provided to patients with breast cancer.
Επιπτώσεις των ήπιων μορφών τουρισμού σε αγροτικές και ορεινές περιοχές
Authors: Αλεξίου Σπυρίδων
Published: April 2023

Η διατριβή διερευνά τις επιπτώσεις των ήπιων μορφών τουρισμού σε αγροτικές και ορεινές περιοχές στην Στερεά Ελλάδα, και συγκεκριμένα στην Περιφερειακή Ενότητα Ευρυτανίας, αγροτική περιοχή η οποία ικανοποιεί πλήρως το κριτήριο της ορεινότητας (100%). Εντάσσεται στο επιστημονικό πεδίο του Σχεδιασμού και της Πολιτικής για την Ανάπτυξη Τουριστικών προορισμών, με έμφαση στις ήπιες μορφές τουρισμού. Οι αγροτικές και ορεινές περιοχές χαρακτηρίζονται από αναπτυξιακές αδυναμίες, από ιδιαιτερότητες ως προς την πληθυσμιακή τους συρρίκνωση, την περιορισμένη παραγωγική τους βάση, τις κλιματολογικές συνθήκες, την πρόσβαση, την υστέρηση σε τεχνολογικές υποδομές κ.ά., με αποτέλεσμα την απομόνωση, την υποβάθμιση και τη διεύρυνση της ανισότητας σε σχέση με τον εθνικό μέσο όρο. Ο τουρισμός έχει θεωρηθεί ως ένα αναπτυξιακό εργαλείο το οποίο μπορεί, υπό προϋποθέσεις, να συμβάλλει στην ενίσχυση της τοπικής οικονομίας, στην ενδυνάμωση της κοινωνίας και του πληθυσμού και στην άμβλυνση των ανισοτήτων. Αποτελείται από δύο μέρη: Στο πρώτο μέρος αναπτύσσεται το θεωρητικό υπόβαθρο της διατριβής, και στο δεύτερο το μεθοδολογικό υπόβαθρο και η έρευνα. Η παρούσα έρευνα υιοθετεί μία μεικτή μέθοδο («τριγωνοποίηση») η οποία περιλαμβάνει επισκόπηση δεδομένων δευτερογενούς έρευνας, εμπειρική έρευνα με ερωτηματολόγιο και ημιδομημένη συνέντευξη. Στα ευρήματα της έρευνας αποτυπώνονται τόσο οι επιπτώσεις που καταγράφηκαν στον προορισμό στους βασικούς τομείς μιας αναπτυξιακής διαδικασίας (οικονομία, κοινωνία, πολιτισμό, περιβάλλον), όσο και ορισμένες κρίσιμες πτυχές της οι οποίες επηρέασαν (και επηρεάζουν) την εξέλιξη της τουριστικής ανάπτυξης της Ευρυτανίας, τη δυναμική αλλά και τις σημαντικές αδυναμίες ως απόρροια του τρόπου με τον οποίο πραγματοποιήθηκε η προώθηση και η διαχείριση του τουρισμού.
The interaction between brain-based learning strategies and patterns of infographics and its influence on the development of information concepts among Saudi undergraduate cybersecurity students
Authors: Mohammed Yasser Shabaan Abdelaziz , Daif-Allah Ayman Sabry
Published: April 2023

The study reported in this paper investigates the impact of the interaction between brain-based learning strategies (spaced repetition and distributed practice - mental models) and patterns of infographics (static/animated) in e-learning environments and its impact on the development of informational concepts among cybersecurity students. The quantitative data were collected by means of Information Concept Test to determine the levels of information concepts according to the Frayer model (1969). The research sample consists of 80 male and female undergraduate students in Qassim University, who were classified into four quasi-experimental groups according to their preferred patterns in the infographic. Quantitative analysis of findings from this study shows an effect for the interaction between the variables of brain-based learning strategies (spaced repetition and distributed practice - mental models) and patterns of infographics (static/animated) in e-learning environments in the test scores of information concepts in the post-administration, where the significance level (.011) is less than the significance level (0.05). Findings also revealed that the repetition of information at increasing intervals of time using the infographics is effective to learning concepts in an organized manner and to improving short memory. Furthermore, the mental model’s strategy also helped to retain information. The study recommends encouraging the use of brain-based learning strategies and patterns of infographics (static/animated) in e-learning environments to explore the relationships between different scientific concepts, to expand students’ knowledge, and to discover inter-relationships between different subject elements. The study provides a platform for further research to employ different brain-based learning strategies within e-learning environments to acquire higher-order thinking skills and improve students' memory and mental capacity with the use of modern technological techniques that achieve learning quality.
Prevalence and risk factors of posttraumatic stress disorder in COVID-19
Authors: Medina-Ortiz Oscar , Oses-Gil Alejandro , Arenas-Villamizar Vivian Vanessa , Ortega Angel , Rojas Milagros , Chávez-Castillo Mervin , Araque-Castellanos Franlet
Published: April 2023

Posttraumatic stress disorder (PTSD) has a prevalence of 2%–5% in the general population. COVID-19 is regarded as a traumatic agent that can increase the prevalence of this disorder to up to 30%. A documentary review was thus conducted, which included 13 studies on the presence of PTSD in patients who have survived COVID-19 infection and the possible associated factors. Female and young age, as well as other aspects associated with economic losses or living alone, could influence the appearance of this psychological sequela. A preventive mental healthcare program could be implemented during infection in such patients with COVID-19 who show the characteristics described in most studies.
Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis
Authors: Scemama Alice , Tailor Artysha , Di Cio Stefania , Dibble Matthew , Gautrot Julien , Biddle Adrian
Published: April 2023

Metastasis occurs when cancer cells leave the primary tumour and travel to a secondary site to form a new lesion. The tumour microenvironment (TME) is recognised to greatly influence this process, with for instance the vascular system enabling the dissemination of the cells into other tissues. However, understanding the exact role of these microenvironmental cells during metastasis has proven challenging. Indeed, in vitro models often appear too simplistic, and the study of the interactions between different cell types in a 3D space is limited. On the other hand, even though in vivo models incorporate the TME, observing cells in real-time to understand their exact role is difficult. Horizontal compartmentalised microfluidic models are a promising new platform for metastasis studies. These devices, composed of adjacent microchannels, can incorporate multiple cell types within a 3D space. Furthermore, the transparency and thickness of these models also enables high quality real-time imaging to be performed. This paper demonstrates how these devices can be successfully used for oral squamous cell carcinoma (OSCC) metastasis studies, focusing on the role of the vascular system in this process. Conditions for co-culture of OSCC cells and endothelial cells have been determined and staining protocols optimised. Furthermore, several imaging analysis techniques for these models are described, enabling precise segmentation of the different cell types on the images as well as accurate assessment of their phenotype. These methods can be applied to any study aiming to understand the role of microenvironmental cell types in cancer metastatic dissemination, and overcome several challenges encountered with current in vitro and in vivo models. Hence, this new in vitro model capable of recapitulating important aspects of the cellular complexity of human metastatic dissemination can ultimately contribute to replacing animal studies in this field.
Insurance Automated Information System and Its Importance for the Financial Market
Authors: Smirnov E.
Published: April 2023

Improving insurance legislation in the interests of solving the problems of the national financial market, the Rus-sian Parliament at the end of 2022 adopted Federal Law No. 594-FZ, which provides for the creation of an automated insurance information system (hereinafter referred to as AIS insurance).
CATEGORIZAÇÃO DE PAÍSES EM FUNÇÃO DAS VARIÁVEIS QUE COMPÕEM O BETTER LIFE INDEX
Authors: Costa Helder Gomes , Azevedo Glaucia Da Costa , De Souza Luciano Azevedo , Eufrazio Edilvando Pereira
Published: April 2023

O Better Life Index (BLI) é um respeitado indicador desenvolvido pela Organization for Economic Cooperation and Development (OECD) para avaliar o bem-estar dos países voltado para decisões organizacionais, governamentais ou mesmo pessoais. Os países são analisados segundo 24 variáveis organizadas em 11 dimensões, as quais são agregadas no BLI calculado individualmente pra cada país. Uma lacuna existente neste contexto é a falta de agrupamento dos páises em acordo com as métricas do BLI, de forma a permitir o planejamento de ações para “pacotes” de países. O objetivo do presente estudo é contribuir para suprir essa carência por meio da aplicação de método de método de clusterização aos dados do BLI. Foi desenvolvido e implementado um código python que utilizou o algoritmo de clusterização kmeans, disponibilizado no pacote scikitlearn para aplicações desenvolvidas em python. Ainda como parte da codificação python, foi utilizado o pacote folium para a plotagem dos dados em um gráfico do tipo mapa-mundi.. A clusterização obtida possibilita a visualiazação em um mapa as classificações obtidas, o que fornece subsídios visuais para a tomada de decisões e políticas.
A polissemia do item lexical ‘cartão’ na ótica da Linguística Cognitiva e suas redes de sentido inerentes
Authors: Oliveira Guilherme Delgado
Published: April 2023

Este trabalho insere-se na perspetiva da Linguística Cognitiva sob o descurtino da polissemia. Tem como finalidade analisar a polissemia do vocábulo ‘cartão’ em termos lexicográficos e da linguagem em uso. Por isso, através de um corpus linguístico, primeiramente, dicionarístico, discutem-se os sentidos enformadores do item a partir do seu protótipo.  De seguida, tenta-se examinar através das primeiras 1000 ocorrências da plataforma CETEMPúblico os mútiplos sentidos que a palavra encerra numa ótica da linguagem experiencialista. Serve-se das análises empreendidas para a elaboração de duas propostas de redes de sentido das quais concluímos  categoricamente que (i) a análise lexicográfica é mais restritiva enquanto a da linguagem em uso é mais produtiva e dinâmica; (ii) dois são os principais mecanismos concetuais envolvidos na construção desses sentidos múltiplos – a metáfora e a metonímia, sendo a primeira por similaridade e a segunda por contiguidade.
Linguagem, Cultura e Cognição: da Filosofia pela Linguística Antropológica à Linguística Cultural
Authors: Schröder Ulrike
Published: April 2023

Neste artigo, discorremos sobre o desenvolvimento de abordagens focalizadas na relação entre linguagem, cultura e cognição no decorrer de três séculos. Começamos com o crescimento de um interesse mais sucinto pela relação entre língua e pensamento no século dezoito junto ao empirismo, ao qual, pouco a pouco, se juntou o terceiro elemento, a cultura, na transição do idealismo para o romantismo até que, a partir do século vinte, iniciaram-se as primeiras pesquisas empíricas na interface da Antropologia e da Linguística no terreno norte-americano. Logo, quase duas décadas após o surgimento da Linguística Cognitiva, na segunda metade dos anos noventa, nasceu a Linguística Cultural como uma corrente que visa a unir as questões da Linguística Cognitiva àquelas da Linguística Antropológica ao propor conceitos específicos na interface desses dois campos de atuação. Após ter apresentado as premissas e os conceitos centrais da Linguística Cultural, direcionaremos nosso olhar para os temas que estão em foco atualmente, tais como inglês como língua franca, comunicação intercultural, fala-em-interação multimodal, World Englishes e línguas pluricêntricas a partir de pesquisas baseadas em corpora.
Functional Outcome of Unstable Intertrochanteric Femur Fracture Patients Treated with Trochanteric Fixation Nail
Authors: Mahale Yashwant J , Kadu Vikram Vilasrao
Published: April 2023

Introduction: Intertrochanteric fractures are disabling injuries that most commonly affect the elderly population. These fractures have a tremendous impact on both the health-care system and society in general. These fractures can be managed by conservative methods, but mal-union and complications of prolonged immobilization are the result. Thus, surgery by internal fixation is the ideal choice. Dynamic hip screw was the gold standard treatment for intertrochanteric fractures before intramedullary devices were developed. These devices have the advantage of being an intramedullary fixation device, shorter lever arm of devices causing less tensile strain on the implant, controlled fracture impaction due to the incorporation of sliding hip screw, shorter operative duration, and less soft tissue dissection. In view of these consideration, this study of management of unstable intertrochanteric fractures using trochanteric fixation nail (TFN) is taken up to assess the outcome in terms of adequacy of fixation and results. Methods: In a retrospective controlled study, 40 patients of unstable intertrochanteric fracture were treated by TFN. Mean age group of the patient was 61.78 years. 26 cases showed union at 3 months, 13 cases showed union at 4 months, and 1 case showed union at 5 months duration. Results: Functional results were assessed in the 40 cases available for follow-up. Excellent results were noted in 10 cases, good in 27 cases, fair in 3 cases, and none had poor result. Anatomical results were assessed by presence or absence of shortening and range of movements. 37 cases had good results and 3 had poor result. Conclusion: At present, we consider that the TFN is a good minimally invasive implant for unstable intertrochanteric fracture when closed reduction is possible. Technical and mechanical complications were mostly related to the operative technique and the type of fracture and pre-operative reduction of the fracture. Keywords: Shortening, trochanteric fixation nail, unstable intertrochanteric fractures.
A Rare Case of Simultaneous Bilateral Elbow Dislocation in a 25 year old Lady following a Simple Fall – An Unusual Mode of Injury
Authors: Nekkanti Supreeth , Vijay C , Theja Sujana , Shankar R Ravi , Patel Ishani
Published: April 2023

Introduction: Bilateral elbow dislocation is a rare injury, with only a small number of case reports in the literature. The majority of these reports describe associated ligamentous injuries only. Simultaneous bilateral radial head fracture in association with bilateral elbow dislocation has only been described on two occasions previously. Case Report: We report an extremely rare case of simultaneous bilateral elbow dislocation in a 25 years woman following self-fall. Bilateral elbow dislocation with bilateral radial head fractures was confirmed radiographically. Closed reduction under sedation was performed in the emergency room. The patient was immobilized for 5 weeks. The patient was mobilized and had good function of bilateral elbow at 8-month follow-up. Conclusion: The purpose of this report was to describe a very rare injury pattern, to present the treatment approach chosen for this case, and to emphasize the importance of early mobilization following bilateral elbow dislocation. Keywords: Bilateral elbow dislocation, female, rare case report, simultaneous.
Comparison of Various Modalities of Treatment for Tibia Plateau Fracture
Authors: Herode Prafulla , Shroff Abhijeet , Sadaria Mohan , Patel Jeegar , Uchale Satish
Published: April 2023

Background: Tibial plateau fractures are quite challenging for orthopaedic surgeons,and earlier, most of tibial plateau fractures were treated conservatively which resulted in joint line incongruity, early osteoarthritis, and knee stiffness. Now, treatment of these fractures has changed. We did this study to compare the outcome of different modalities of treatment in tibial plateau fractureswith advantages and disadvantages. Materials and Methods: During 2 years from April 2015 to May 2017, 30 patients were treated for closed tibial plateau fractures, of which 4 patients were treated by conservative methods, and 26 patients were treated by surgical methods. Results: Result showed the higher involvement of young, middle-aged males than older females with maximum Type I fractures. Operative results were better in complicated fractures which treated with buttress plate where there was no much difference in the outcome of simple TypesI and II fractures, and hence, we preferred conservative modality for them. Conclusion: The correct method of management of tibial condylar fractures depends on good clinical judgment. If rational treatment is to be instituted, the surgeon must have sound knowledge of the pattern of the injury and a clear understanding of the knee examination and imaging studies and must be familiar with a variety of techniques available at present for treating tibial condyle fractures. Keywords: Tibial plateau, conservative, cannulated cancellous screw, buttress plate.
Two Staged Management Of Proximal Tibial Fractures With Impending Compartment Syndrome By Temporary External Stabilisation And Fasciotomy And Delayed Definative Fixation
Authors: Qureshi M. Shoaib , Panat Mangesh , Israni Pratik
Published: April 2023

Introduction: High energy proximal tibia fractures with soft tissue involvement presenting with dicolored patches over the leg and severe swelling, compound wounds, blisters with tight compartments and absent or feeble dorsalis pedis or posterior tibial arteries warrant to go in for a staged procedure. In patients with multiple injuries, an external fixator can be applied quickly with minimal blood loss for unstable periarticular fractures around the knee. Two-stage procedures involve (1) early joint spanning external fixators with fasciotomy for the medial and posterior compartments, (2) and late definitive fixation with plates or nails and with skin grafting. Materials and Methods: In our study, we present a short series of 15 proximal tibial fractures with impending compartment syndrome. Patients selected for this study were (1) closed proximal tibia fracture intra- and peri-articular and metaphysis diaphysis junction communited and noncommunited fractures (2) impending compartment syndrome evaluated based on excessive swelling, tight compartments, blisters over skin, feeble or absent dorsalis pedis or posterior tibial pulsations, color Doppler suggestive of severe subcutaneous edema associated with monophasic or absent flow over distal arteries. Exclusion criteria: (1) Low energy proximal tibia fracture without soft tissue insult and compound wounds over the proximal tibia fractures, (2) associated popliteal artery injuries. Conclusion: With the initial application of a bridging external fixator followed by delayed internal fixation protocol for pilon fractures has been successful in reducing the historically high rates of wound complications associated with these high-energy injuries. As well this protocol allows the use of minimally invasive plate osteosynthesis technique which is based on a combination of the principles of stability, restoration of anatomy and early motion while eliminating the need for excessive soft tissue dissection. Keywords: Proximal Tibial fractures, External fixators, Fasciotomy, Definitive fixation.
Percutaneous Release of Trigger Finger: A Safe And Cost Effective Procedure
Authors: Nair Vinod , Chaudhary Amit , Desouza Clevio , Hurkat Harshal , George Shiju
Published: April 2023

Introduction: Trigger finger is a common cause of pain and disability of the hand. Trigger finger (or thumb) arises either from thickening of the flexor tendon sheath (which occurs following tenosynovitis of infective, traumatic or rheumatolgical origin) or from nodular thickening of the flexor tendon itself which may be congenital. Percutaneous release results in earlier functional recovery and patient satisfaction. This is a cost-effective and rapid method which saves a surgical procedure and results in a better functional outcome. KeyWords: Trigger finger, percutaneous release, outpatient treatment, cost-benefit analysis.
With the POUM International volunteers on the Aragon Front (1936-1937)
Authors: Durgan Andy
Published: April 2023

Mentre que la història de les Brigades Internacionals està ben documentada, es coneix poc sobre els centenars de voluntaris estrangers que van lluitar amb les milícies obreres. Aquest article proporciona un resum dels orígens i característiques dels mes o menys sis-cents milicians internacionals que lluitaven amb el POUM durant els primers deu mesos de la Guerra Civil. Es contrast seva experiència amb la versió trobada en Homenatge a Catalunya de George Orwell, examinant tant el seu paper militar com la seva subseqüent destí després de la il·legalització del partit al juny 1937 i la dissolució de les seves milícies. Calumniats com «agents del feixisme», dotzenes d’aquests voluntaris van ser detinguts. No obstant això altres seguien lluitant amb altres unitats, incloent les Brigades Internacionals. Finalment, l’article examina la sort d’alguns d’aquests voluntaris com a combatents i víctimes a la Segona Guerra Mundial.
La batalla de la Fatarella, 1938. Museografia, iconografia, recreació i memòria. Un model transversal de recerca didàctica
Authors: Sospedra Rafel , Feliu Maria , Wilson Ann Elisabeth , Sebares Gemma , Hernàndez Mar
Published: April 2023

El combat de Raïmats, succeït el darrer dia de la batalla de l’Ebre (15 de novembre de 1938) ha estat investigat des de diverses òptiques per part del grup de recerca DIDPATRI en una perspectiva interdisciplinar i transversal. La recerca va començar amb una petició de l’associació cívica Lo Riu el 2013 a la Universitat de Barcelona que van aconduir a una intensa campanya arqueològica en una clara dinàmica de recerca pública. En els anys posteriors i fins el 2018 les accions sobre Raïmats s’han multiplicat incorporant experiències sobre museografia a l’aire lliure;  visites escolars; turisme de camps de batalla; recreació històrica i generació d’iconografia didàctica. Tot plegat la dinàmica no exhaurida, es contextualitza també en una dinàmica pedagògica d’investigació acció en la qual els plantejaments didàctics assoleixen protagonisme. L’experiència transversal de Raïmats incorpora també una vessant explícita de memòria en tant que el lloc s’ha convertit en un referent significatiu de la batalla de l’Ebre.
Xarli, el soldat que va morir dues vegades
Authors: Hernàndez Cardona Francesc Xavier
Published: April 2023

La tardor del 2011 investigadors del CSIC i del grup de recerca DIDPATRI de la Universitat de Barcelona, van estar excavant a la zona de Raïmats, un dels escenaris dels darrers combats de la batalla de l’Ebre. En els treballs es van localitzar les restes esquelètiques d’un soldat que havien quedat colgades just en el lloc on havia mort. En conèixer la troballa el Departament de Governació i Relacions Institucionals invocant la Llei de Fosses es va emparar de les restes del soldat i de resultes es va generar una important polèmica sobre el paper de l’administració en les polítiques de memòria.
Les rutes de l’exili del MUME: una dècada connectant espais de memòria a la Catalunya transfronterera
Authors: González David
Published: April 2023

Els espais de memòria del territori català transfronterer es reparteixen a nord i sud dels Pirineus i estan lligats a la història i la memòria de l’exili republicà, així com a d’altres episodis històrics relacionats com els fugits de la Segona Guerra Mundial, les fortificacions militars de frontera, o la mateixa Guerra Civil espanyola en directa relació amb el territori.Des de la seva apertura al públic al febrer de l’any 2008, el Museu  Memorial de l’Exili – MUME de La Jonquera s’ha convertit en l’equipament cultural catalitzador de gairebé totes les iniciatives per a la recuperació i divulgació de la memòria de l’exili republicà. La presentació d’una solvent exposició permanent, una dinàmica programació d’exposicions temporals, la participació activa en activitats relacionades amb la recerca, així com un servei educatiu amb accions cada cop més consolidades, han fet arrelar al MUME dins el teixit social i cultural del país. D’entre totes les activitats dutes a terme de manera regular, les rutes de l’exili, nucli de l’oferta del museu a través del seu servei educatiu, són l’autèntic eix comunicadordel MUME amb el territori. Aquest article abordarà, de manera sintètica, l’anàlisi de les diferents rutes existents en el territori català transfronterer al voltant de la temàtica de l’exili. Des dels seus orígens com a proposta pedagògica a nivell universitari fins l’actual oferta consolidada del servei educatiu del MUME, es mostraran aquells espais establerts com a nodes, així com també seran mencionades les diferents narratives sorgidesde l’execució de les diverses rutes existents. El cas particular aquí analitzat referma la capacitat de les rutes per exercir com una eina molt valuosa per tal d’encetar diferents dinàmiques de valorització del patrimoni.
«Fugint de les bombes. De la Barceloneta a la zona alta, 1937-1939»
Authors: Gallego Laia
Published: April 2023

«Fugint de les bombes. De la Barceloneta a la zona alta, 1937-1939»(Centre Cívic Barceloneta, 1-24 de febrer de 2018)
La España de Franco: la limpieza de la cultura y la resistencia de los romanceros
Authors: Pagès i Blanch Pelai
Published: April 2023

El inicio de la guerra civil española propició el estallido de un fenómeno cultural sin precedentes en la historia de España: la aparición de los Romanceros como forma de lucha política e ideológica. Desde la Alianza de Intelectuales Antifascistas —con poetas como José Bergamín y Rafael Alberti— hasta no pocos escritores y poetas anónimos se propició la aparición de romanceros, cuya temática era enormemente variada: desde romances que exhortaban la valentía del pueblo hasta los burlescos contra los militares insurrectos, la variedad de temas tratados era muy grande, hasta tal punto que ponen de relieve que los romanceros se acabaron utilizando en la España republicana como arma de lucha y resistencia.
Arqueologia pública, iconografia didàctica i memòria de la batalla de l’Ebre
Authors: Gonzàlez Sanz Myriam , Sebares Valle Gemma , Hernandez Pongiluppi Mar , Boj Cullell Isabel
Published: April 2023

La Batalla de l’Ebre (1938) va ser el darrer gran combat de la Guerra Civil espanyola. Al llarg de 116 dies, soldats i màquines es van enfrontar assajant noves tècniques, tecnologies i tàctiques de combat que tindrien un paper principal en el conflicte mundial imminent. La utilització de trinxeres, tancs i aviació amb nous criteris va fer capgirar les concepcions quan a manera de fer la guerra. El present treball recull la experiència del grup de recerca DIDPATRI (Didàctica del Patrimoni) entre el 2009 i el 2019 a l’entorn de la Batalla de l’Ebre tot assajant enfocaments de recerca transversal i holística a l’entorn de la història, l’arqueologia i l’antropologia, amb una praxis de socialització dels sabers generats a partir de la museografia i la iconografia didàctica, i amb una voluntat paral·lela de promoure accions de memòria democràtica
El compromís artístic de Joan Commeleran amb Catalunya durant la guerra civil (1936-1939)
Authors: Santacreu Soler José Miguel
Published: April 2023

Commeleran és un dels nombrosos artistes plàstics catalans oblidats per la tradició acadèmica. El seu compromís artístic amb Catalunya durant la guerra civil encara no ha rebut el reconeixement que mereix. Els seus dibuixos constitueixen una visió vigorosa i personal del temps viscut, motiu pel qual li dediquem el present article. L’objectiu és recuperar i donar a conèixer les seues creacions artístiques més significatives dels temps de guerra; perquè són una documentació gràfica de les vivències de les persones no combatents durant la guerra a Catalunya, d’algunes activitats culturals organitzades per la Generalitat de Catalunya i de la pràctica per part dels catòlics d’un intimisme religiós en la rereguarda republicana
Recreació UB Didpatri. Compromís amb la didàctica de la història i el patrimoni
Authors: Miró Serra Oriol , Sospedra Roca Rafael
Published: April 2023

El grup de recreació UB-DIDPATRI, estabilitzat a partir de 2016, centrat en la Guerra Civil espanyola es un dels pocs existents amb perfil universitari. En la seva breu trajectòria ha aconseguit la vinculació al món de la recreació de nombrosos estudiants i llicenciats i no ha parat de créixer quant a activitats i projecció.
The red International of Labour Unions (RILU), 1920-1937. Reiner Tosstorff (1920)
Authors: Zoffmann Rodríguez Arturo
Published: April 2023

The red International of Labour Unions (RILU), 1920-1937.Reiner Tosstorff (1920)
Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC
Authors: Cheramangalam Rajit Narayanan , Anand Tarana , Pandey Priyanka , Balasubramanian Deepa , Varghese Reshmi , Singhal Neha , Jaiswal Sonal Nagarkar , Jaiswal Manish
Published: April 2023

Cells under mitochondrial stress often co-opt mechanisms to maintain energy homeostasis, mitochondrial quality control and cell survival. A mechanistic understanding of such responses is crucial for further insight into mitochondrial biology and diseases. Through an unbiased genetic screen in Drosophila, we identify that mutations in lrpprc2, a homolog of the human LRPPRC gene that is linked to the French-Canadian Leigh syndrome, result in PINK1-Park activation. While the PINK1-Park pathway is well known to induce mitophagy, we show that PINK1-Park regulates mitochondrial dynamics by inducing the degradation of the mitochondrial fusion protein Mitofusin/Marf in lrpprc2 mutants. In our genetic screen, we also discover that Bendless, a K63-linked E2 conjugase, is a regulator of Marf, as loss of bendless results in increased Marf levels. We show that Bendless is required for PINK1 stability, and subsequently for PINK1-Park mediated Marf degradation under physiological conditions, and in response to mitochondrial stress as seen in lrpprc2. Additionally, we show that loss of bendless in lrpprc2 mutant eyes results in photoreceptor degeneration, indicating a neuroprotective role for Bendless-PINK1-Park mediated Marf degradation. Based on our observations, we propose that certain forms of mitochondrial stress activate Bendless-PINK1-Park to limit mitochondrial fusion, which is a cell-protective response.
Factors influencing adoption of oral health promotion by antenatal care providers in Moyo district, North-Western Uganda
Authors: Lulu Patrick Madrama , Nanyingi Miisa
Published: April 2023

Background

Oral health promotion (OHP) during pregnancy is an important global public health and basic human right issue related to quality of life. Several statements and guidelines have been published emphasizing the need for improved oral health care of pregnant mothers, prenatal care providers have missed this critical opportunity. In this study, we assessed factors influencing adoption of oral health promotion by antenatal care providers.

Materials and methods

A descriptive cross-sectional study design that employed both quantitative and qualitative data collection methods and analysis. 152 samples determined using Yamane’s 1967 and stratified sampling technique was used. Three FGDs and six KI interviews were held. Univariate, bivariate and multivariate analyses were done using SPSS (20.0) and ATLAS Ti for qualitative analysis.

Results

Adoption of OHP was low 28% (42). Factors influencing adoption were age of respondents (OR = 0.066, 95%CI = 0.009–0.465, p = 0.006*), level of care of health facility (OR = 0.050, 95%CI = 0.008–0.322, p = 0.002*), good understanding between dentists and ANC providers (OR = 0.283, 95%CI = 0.084–0.958, p = 0.042*), availability of practice guideline for OHP in ANC (OR = 0.323, 95%CI = 0.108–0.958, p = 0.043*), number of years at work (p = 0.084), being knowledgeable (OR = 2.143, 95%CI = 0.864–5.311, p = 0.100), having skills to advance OHP(OR = 0.734, 95%CI = 0.272–1.984, p = 0.542), Management being good at influencing new practices (OR = 00.477.734, 95%CI = 0.227–2.000, p = 0.477). More emphasis on national and local of oral health issues, continuous staff training on oral health, dissemination of National oral health policy (NOHP) were some of key issues that emerged from the qualitative results.

Conclusion

Adoption of OHP was low. This was attributed to age, number of years spent at work, level of health facility, having good understanding between dentists and ANC providers, availability of practice guidelines, dissemination of National oral health policy, continuous staff training. We recommend the current NOHP to be reviewed, develop prenatal OHC guidelines, enhance the capacity of ANC providers through training, collaboration with dentists and launch official adoption of OHP.
Increased malaria incidence following irrigation practices in the Endorheic Rift Valley Basin of Sidama Region, Ethiopia
Authors: Hawaria Dawit , Kibret Solomon
Published: April 2023

Background

Water resource development practice such as irrigation is key to ensuring economic growth and food security in developing countries. However, unintended public health problems such as malaria linked to such development projects have been a concern. This study aimed to determine the impact of irrigation on malaria incidence and vector mosquito abundance in southern Ethiopia.

Methods

Eight years’ malaria morbidity data were extracted from the medical registers of health facilities in both irrigated and non-irrigated settings. Additionally, adult and larval malaria vector surveys were carried out in both irrigated and non-irrigated villages. The trend of malaria incidence, case distribution across age and sex, seasonality, parasite species proportion, and mosquito density were analyzed and compared between irrigated and non-irrigated villages.

Results

The result showed that annual mean malaria incidence was 6.3 higher in the irrigated (95% CI: 0.7–33.6) than in the non-irrigated villages (95% CI: 1.2–20.6). Although a remarkable declining trend in malaria incidence was observed for four successive years (2013–2017), a significant resurgence between 2018 and 2020 was noted following the introduction of irrigation schemes. The densities of adult Anopheles mosquitoes were 15-fold higher in the irrigated compared to non-irrigated villages. Of the total potential mosquito-breeding habitats surveyed, the majority (93%) were from irrigated villages.

Conclusion

Higher malaria incidence, adult Anopheles density, and mosquito-breeding habitat were recorded in the irrigated villages compared to non-irrigated villages. These observations have important implications for the effectiveness of existing malaria interventions. Environmental management could help reduce the breeding of malaria vector mosquitoes around irrigation schemes.
Race Against the Clock: An Atypical Cause of Abdominal Pain
Authors: Panagos Katherine , Clinton Joe , Ji Byung , Canakis Andrew , George Lauren
Published: April 2023

Aortoenteric fistula is a rare medical emergency that carries a high risk of mortality. In cases that present without gastrointestinal bleeding, it can be difficult to accurately diagnose and, therefore, properly manage. This case depicts a patient who presented with diffuse abdominal pain and obstipation. After imaging, esophagogastroduodenoscopy, and surgery, he was found to have an aortoduodenal fistula with an infected graft. Our case highlights the importance of maintaining a high index of suspicion for an aortoenteric fistula in a patient with vague abdominal symptoms and a significant history of vascular grafts.
Diálogo en Gadamer y conformación de comunidad de vida humana en las sociedades democráticas contemporáneas
Authors: Cuchumbé Holguín Nelson Jair
Published: April 2023

Desde el planteamiento de Gadamer sobre diálogo se muestra que cuando los interlocutores efectúan la conversación en armonía con el proteger el derecho de opi-nión y el reconocer de modo recíproco los límites de los puntos de vista arriesgados, es factible configurar comunidad de vida humana en la mutua estima y aprobar la validez de otros juicios como respuestas que ayudan con el proceso interhumano de entendimiento común. Y en este realizar el diálogo así tiene lugar una creación nueva de sentido que con la participación de la pluralidad lleva a cabo simultáneamente la actualización del habitual modo de efectuar la formación de comunidad de vida. En la medida en que los interlocutores ejercen el entender sus opiniones en relación con la pregunta orientadora del diálogo y reconocen la finitud de sus puntos de vista como posibilidades entre otras, se contribuye con el establecimiento de comunidad de vida humana en un sentido completamente distinto trasformando con ello de un modo u otro las prácticas habituales de relación e integración social. En primer lugar, se explica el vínculo entre experiencia comprensible y conversación; y, en segundo lugar, se establece el modo como Gadamer describe el presupuesto hermenéutico de la pertenencia y su relación con la creación de un nuevo sentido que incumbe a la experiencia comprensible del entendimiento interhumano en la conversación
De la “humaneidad no-incrementada” al “humanismo real de lo no-humano”: la polémica de Walter Benjamin con el Übermensch
Authors: López Nicolás
Published: April 2023

El presente artículo se propone mostrar que la idea de una “humaneidad no-incre-mentada”, que define el concepto de lo político de Walter Benjamin a principios de la década de 1920, se continúa subrepticiamente en lo que, en los apuntes preparatorios a su ensayo sobre Karl Kraus de 1931, llama “humanismo real de lo no-humano”. Las discrepancias que en cada caso Benjamin establece con la célebre noción de Übermensch acuñada por Friedrich Nietzsche será el hilo conductor que permite vincular ambos momentos. A partir de ello, se muestra cómo emerge en los escritos de Benjamin una singular política de lo (post)humano.
Crystal structure of baryte from Mine du Pradet (France)
Authors: Paulsen Christian , Galéa-Clolus Valérie , Pöttgen Rainer
Published: April 2023

BaSO4, orthorhombic, Pnma (no. 62), a = 8.8806(8) Å, b = 5.4539(5) Å, c = 7.1570(7) Å, V = 346.64(6) Å3, Z = 4, Rgt
(F
2) = 0.0141, wRref
(F
2) = 0.0329, T = 293 K.
A ESCOLA COMO ESPAÇO DA (IN) DIFERENÇA?
Authors: Teixeira Barrios Simone , Helena Lima Nunes Georgina
Published: April 2023

Este artigo tem como objetivo, fazer uma discussão com alguns/mas autores/as que trabalham com as categorias de gênero, raça e deficiência, de forma a refletir sobre a escola enquanto possibilidade de concretizar-se como espaço de respeito às diferenças. Sob esse direcionamento, o trabalho se remete a uma proposta de pesquisa acadêmica em construção, cuja presença da mulher negra com deficiência na escola ao ser campo de estudo, possa favorecer práxis sociais que possibilitem refazer percursos que se oponham àqueles que sustentam a colonização das mentes e de corpos fora do padrão hegemônico. O texto apresentado traz uma análise interseccionada dos demarcadores de gênero, raça, deficiência e também de geração. Neste sentido, procura-se compreender como as opressões interseccionadas podem ser observadas de modo a engendrar sentimentos de acolhimento, contrários, portanto, aos de preconceitos e discriminações de qualquer natureza. Sabemos que, a escola e a sociedade, estão sustentadas em uma perspectiva hegemônica que confere “normalidade” e “poder” àqueles/as representados/as pela masculinidade, supremacia branca e hierarquias sócio-econômicas. Tal concepção aponta a memória e a história da civilização sob a égide do colonizador ou de uma colonização que se perpetua sob a forma de colonialidade[1]. Defendemos[2] nessa escrita, que a escola pode ser um espaço fundamental e transformador de relações sociais pautadas em intolerâncias, por isso, violentas. Cabe ressaltar, que a problematização proposta decorre de uma experiência concreta que irá balizar uma investigação de doutoramento, com isso, abre-se a oportunidade de dialogar com a literatura existente e anunciar outras possibilidades de compreensão e mudança no que diz respeito às atitudes políticas, pedagógicas e epistêmicas que se contrapõem ao machismo, capacitismo e racismo.
RUNX3: A Location-oriented Genome Coordinator
Authors: Xu Tianshu , Liang Yancan , Huang Zhiquan , Huang Zixian
Published: April 2023

Transcription factors are key components in gene expression and are associated with various diseases. Transcription factors maintain the stability of gene transcription and cell function. Among the transcription factors, the Runt-related transcription factor (RUNX) family regulates growth and development in a tissue-specific manner and is involved in tumorigenesis. The function of an important member of the RUNX family, RUNX3, was shown to be closely related to its subcellular localization. Normally, RUNX3 promotes or represses gene transcription in the nucleus; however, when RUNX3 is restricted in the cytoplasm, RUNX3 fails to function and only has a minor effect o gene expression. Hence, the risk of tumorigenesis cannot simply be equated with the level of RUNX3 expression, which makes the diagnosis and treatment of cancer more complicated. The cytoplasmic localization of RUNX3 has been shown to be associated with a variety of tumors. Herein we have summarized the current information on RUNX3 mis-localization and RUNX3 promotion of tumorigenesis, thus providing new insight for future investigations to elucidate the mechanisms by which RUNX3 regulates tumorigenesis.