bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Epic Electronic Health Record System for Health Care Research: Scoping Review (Preprint)
Authors: Chishtie Jawad , Sapiro Natalie , Wiebe Natalie , Rabatach Leora , Lorenzetti Diane , Leung Alexander A , Rabi Doreen , Quan Hude , Eastwood Cathy A
Published: July 2023

BACKGROUND

Electronic health records (EHRs) enable health data exchange across interconnected systems from varied settings. Epic is among the 5 leading EHR providers and is the most adopted EHR system across the globe. Despite its global reach, there is a gap in the literature detailing how EHR systems such as Epic have been used for health care research.

OBJECTIVE

The objective of this scoping review is to synthesize the available literature on use cases of the Epic EHR for research in various areas of clinical and health sciences.

METHODS

We used established scoping review methods and searched 9 major information repositories, including databases and gray literature sources. To categorize the research data, we developed detailed criteria for 5 major research domains to present the results.

RESULTS

We present a comprehensive picture of the method types in 5 research domains. A total of 4669 articles were screened by 2 independent reviewers at each stage, while 206 articles were abstracted. Most studies were from the United States, with a sharp increase in volume from the year 2015 onwards. Most articles focused on clinical care, health services research and clinical decision support. Among research designs, most studies used longitudinal designs, followed by interventional studies implemented at single sites in adult populations. Important facilitators and barriers to the use of Epic and EHRs in general were identified. Important lessons to the use of Epic and other EHRs for research purposes were also synthesized.

CONCLUSIONS

The Epic EHR provides a wide variety of functions that are helpful toward research in several domains, including clinical and population health, quality improvement, and the development of clinical decision support tools. As Epic is reported to be the most globally adopted EHR, researchers can take advantage of its various system features, including pooled data, integration of modules and developing decision support tools. Such research opportunities afforded by the system can contribute to improving quality of care, building health system efficiencies, and conducting population-level studies. Although this review is limited to the Epic EHR system, the larger lessons are generalizable to other EHRs.
Implementation of fraud triangle theory: A systematic literature review
Authors: Suryandari Ni Nyoman Ayu , Yadnyana I Ketut , Ariyanto Dodik , Erawati Ni Made Adi
Published: July 2023

Fraud triangle theory popularized by Cressey (1953) and adopted by Statement of Auditing Standards No. 99, states that fraud occurs when there are three elements, namely: pressure, opportunity, and rationalization. This theory is criticized because it is considered unable to describe all the motivations of fraud perpetrators. This study aimed at developing Homer (2020) research, expanding it with criticism and developing variables in the fraud triangle. This research did not only focus on types of fraud based on the fraud tree but also added academic fraud. Methodologically, this research was a systematic literature review using six steps in determining the samples. This study summarized 25 Scopus articles using at least one element of the fraud triangle. From the 25 included studies, 80 percent reviewed the three elements of the fraud triangle in their research. As much as 60 percent of research results supported that the three elements of the fraud triangle can increase fraud motivation. Although the fraud triangle theory has received much criticism, researchers are trying to develop the fraud triangle theory by adding other variables and with theoretical support. This review recommends filling the research gap in developing the fraud triangle theory by looking at previous researches.
Intermediate Transfer Rates and Solid-State Ion Exchange are Key Factors Determining the Bifunctionality of a Tandem CO2 Hydrogenation Catalyst
Authors: Mahnaz Fatima , Mangalindan Jasan , Vito Jenna , Lin Yu-Ting , Akbulut Mustafa , Shetty Manish
Published: July 2023

Probing the interaction between different active sites and transfer of reaction intermediates in bifunctional catalysts for tandem hydrogenation of CO2 is crucial for optimal catalyst design that maximize synergy to achieve high rates and product selectivity. Herein, thermocatalytic conversion of CO2 to hydrocarbon (HC) via a methanol (CH3OH) intermediate was investigated by modulating the placement of In2O3 and HZSM-5 in bifunctional admixtures at temperatures between 350 to 450 °C and 500 psig, to probe the key factors that drive synergy in these bifunctional systems. Analysis of the intermediate CH3OH transfer rates showed that although a millimeter scale placement of In2O3 and HZSM-5 yields a simple tandem reaction with a total HC and methanol CH3OH space-time yield of 8×10-6 molCgcat-1min-1, a microscale placement exhibits a ten-fold increase in catalytic activity with a total HC and CH3OH space-time yield of 8×10-5 molCgcat-1min-1 (at 400 °C) due to a faster advective and diffusive transfer rate of CH3OH. A combination of reactivity, spectroscopy with Raman, X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (PXRD) patterns, microscopy with scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and control experiments on methanol to hydrocarbons (MTH) revealed that further enhancing the reaction intermediate transfer at a nanoscale placement was counteracted by solid-state ion exchange (SSIE) between Brønsted acid sites (H+) of the HZSM-5 with the Inδ+ ions from In2O3, and that the formation of CH4 at the nanoscale placement was likely through CH3OH hydrogenolysis and not CO2 methanation at these intimate distances. Overall, our data showed the interconnected and subtle ways through which bifunctionality of catalysts could be regulated and paves the way for the development of design principles for designing more effective bifunctional catalysts for tandem CO2 hydrogenation.
Simultaneous Electrochemical Exfoliation and Functionalization of 2H-MoS2
Authors: Zhuo Yuling , Kinloch Ian , Bissett Mark
Published: July 2023

MoS2 is a promising semiconducting material that has been widely studied for applications in catalysis and energy storage. The covalent chemical functionalization of MoS2 can be used to tune the optoelectronic and chemical properties of MoS2 for different applications. However, 2H-MoS2 is typically chemically inert and difficult to functionalize directly and thus requires pre-treatments such as a phase transition to 1T-MoS2 or argon plasma bombardment to introduce reactive defects. Apart from being inefficient and inconvenient, these methods can cause a degradation of the desirable properties and introduce unwanted defects. Here, we report a facile and scalable procedure of fabricating functionalized thin (~4 nm) MoS2 layers. We demonstrate that 2H-MoS2 can be simultaneously electrochemically exfoliated and functionalized. The aryl diazonium salts used for functionalization have not only been successfully grafted onto the 2H-MoS2, as verified by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy, but also aid the exfoliation. Electrochemical characterization of MoS2 supercapacitors revealed that the specific capacitance of electrodes produced using this material was increased by 25% when functionalized. This electrochemical functionalization technique could possibly be extended to other types of transition metal dichalcogenides (TMDs), which are also chemically inert, with different functional species to adjust to specific applications.
Challenges and opportunities for exploiting the role of zeolite confinements for the selective hydrogenation of acetylene
Authors: Vito Jenna , Shetty Manish
Published: July 2023

Zeolites, with their ordered crystalline porous structure, provide a unique opportunity to confine metal catalysts, whether single atoms (e.g., transition metal ions (TMIs)) or metal clusters when used as a catalyst support. The confined environment has been shown to provide rate and selectivity enhancement across a variety of reactions via both steric and electronic effects such as size exclusion and transition state stabilization. In this review, we provide a survey of various zeolite confined catalysts used for the semi-hydrogenation of acetylene highlighting their performance, defined by ethylene selectivity at full acetylene conversion, in relationship to the synthesis technique employed. Synthesis methods that ensure confinement with catalyst transition metal location in the extra-framework positions are observed to have the report the highest selectivity to ethylene. However, the underlying molecular factors responsible for selective catalysis within confinement remains elusive due to the difficulty of deconvoluting individual effects. Through the careful use of a combination of characterization and spectroscopic methods, insights into the relationship between the properties of zeolite confined catalysts and their performance have been explored in other works for a variety of reactions. More specifically, operando spectroscopy studies have revealed the dynamic behavior of zeolite confined catalysts under various conditions implying that the structure and properties observed ex-situ do not always match those of the active catalyst under reaction conditions. Applying this type of analysis to acetylene semi-hydrogenation, a simple gas phase reaction, can help elucidate the structure-function relationship of zeolite confined catalysts allowing for more informed design choices and consequently their application to a wider variety of more complex reactions such as the liquid phase hydrogenation of alkynols where solvent effects must also be considered in addition to those of confinement.
The COVID-19 pandemic in Greenland, epidemic features and impact of early strict measures, March 2020 to June 2022
Authors: Noahsen Paneeraq , Faber Louise Lohmann , Isidor Silvia , Fonager Jannik , Rasmussen Morten , Hansen Henrik L
Published: July 2023

Background

The COVID-19 pandemic was of major concern in Greenland. There was a high possibility of rapid transmission in settlements, and an increased risk of morbidity and mortality because of comorbidities in the population and limited access to specialised healthcare in remote areas.

Aim

To describe the epidemiology of the COVID-19 pandemic in Greenland and evaluate the effects of a strict COVID-19 strategy until risk groups were immunised.

Methods

We studied the epidemiology during March 2020 to June 2022. We describe the non-pharmaceutical interventions (NPIs), PCR-confirmed COVID-19 cases and vaccination coverage with data from the registries of the Greenlandic health authority.

Results

We found 21,419 confirmed cases per 100,000 inhabitants (54% female, 46% male), 342 per 100,000 were hospitalised and 16 per 100,000 were admitted to the intensive care unit. The COVID-19 mortality rate was 39 per 100,000, all those affected were aged above 65 years. No excess overall mortality was observed. The vaccination coverage by June 2022 was 71.67 and 41% for one, two and three doses, respectively.

Conclusion

SARS-CoV-2 circulation in Greenland was low, given strict restrictions until all eligible inhabitants had been offered immunisation. The main impact of the pandemic was from May 2021 onwards with increasing numbers of confirmed cases. This occurred after introduction of the vaccine programme, which may have had an influence on the severity of the associated morbidity and mortality experienced. Halting community transmission of SARS-CoV-2 with NPIs until the majority of the population had been immunised was a successful strategy in Greenland.
Influence of Native Saccharomyces cerevisiae Strains on Malvasia aromatica Wines
Authors: Crespo Julia , García Margarita , Arroyo Teresa , Romero Valeria , Cabellos Juan M.
Published: July 2023

Background: In the search of tools to deal with climate change-related effects along with the aim of avoiding the loss of aromatic typicity in wine, two native yeasts strains of Saccharomyces cerevisiae (CLI 271 and CLI 889) were evaluated to determine their influence on white Malvasia aromatica wines aroma composition and sensory characteristics. Methods: The strains were tested versus a commercial yeast strain (LSA). The fermentations were performed on grape must of the Malvasia aromatica variety previously macerated. Wine quality was studied by analysis of oenological parameters together with volatile aroma components using gas chromatography coupled to flame ionization detector (GC-FID) to quantify major volatiles compounds and headspace-solid phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS) to determine terpenoids and C13-norisoprenoids. Sensorial analysis was also realized by an experienced taster panel. Results: Wines from locally-selected yeasts strains used had lower volatile acidity levels and higher concentration of aromatic compounds compared to the commercial strain ones. The yeast strain S. cerevisiae CLI 271 provided wines with a higher concentration of esters related to fruity attributes, especially isoamyl acetate. The tasting panel highlighted the strong floral character of wines from S. cerevisiae CLI 889 fermentation. Conclusions: The use of microorganisms well adapted to climatic conditions can be used to produce quality wines of the Malvasia aromatica variety.
Iron Deficiency Might Impair the Recovery of Left Ventricular Function after Surgical Revascularization in Diabetic Patients: A Retrospective Study
Authors: Nan Yifeng , Tiemuerniyazi Xieraili , Song Yangwu , Chen Liangcai , Yang Ziang , Zhang Shicheng , Feng Wei
Published: July 2023

Background: Iron deficiency (ID) is one of the most common micronutrient deficiencies affecting public health. Studies show that ID affects the prognosis of patients with heart disease, including heart failure, coronary artery disease and myocardial infarction. However, there is limited information regarding the impact of ID on patients undergoing cardiac surgery. This study aimed to evaluate the influence of preoperative ID on the prognosis of type 2 diabetes mellitus (T2DM) patients undergoing coronary artery bypass grafting (CABG). Methods: In the Glycemic control using mobile-based intervention in patients with diabetes undergoing coronary artery bypass to promote self-management (GUIDEME) study, patients with T2DM undergoing CABG were prospectively recruited. In this study, only those patients with preoperative iron metabolism results were enrolled. Patients were grouped based on the presence of preoperative ID. The primary endpoint was defined as the significant improvement of follow-up ejection fraction (EF) compared to postoperative levels (classified according to the 75th percentile of the change, and defined as an improvement of greater than or equal to 5%). Univariable logistic regression was performed to explore the potential confounders, followed by multiple adjustment. Results: A total of 302 patients were enrolled. No deaths were observed during the study period. A higher incidence of the primary endpoint was observed in the ID group (25.4% vs 12.9%, p = 0.015). The postoperative and follow-up EF were similar beween the two groups. In the regression analysis, ID was noticed to be a strong predictor against the significant improvement of EF in both univariable (odds ratio [OR]: 0.44, 95% confidence interval [CI]: 0.22–0.86, p = 0.017) and multivariable (OR: 0.43, 95% CI: 0.24–0.98, p = 0.043) logistic regression. In the subgroup analysis, ID was a predictor of significant improvement of EF in age ≤60 years, male, EF ≤60%, and on-pump CABG patients. Conclusions: In T2DM patients undergoing CABG, ID might negatively affect the early recovery of left ventricular systolic function in terms of recovery of EF 3–6 months after surgery, especially in patients age ≤60 years, males, EF ≤60% and in those undergoing on-pump CABG.
MATHEMATICAL MODELS ONTOLOGY OF TECHNOLOGICAL OBJECTS FOR INDUSTRIAL ENTERPRISES. PART 2. ONTOLOGY IMPLEMENTATION AND VERIFICATION
Authors: Omelchenko О. , Lutska N. , Vlasenko L.
Published: July 2023

The article proposes the implementation of an applied ontology of mathematical models of technological objects for the design of a subsystem of decision-making support, which issues recommendations for the mathematical apparatus in relation to the development goals for the automated management of a food enterprise. It consists of 46 entities with corresponding relationships, attributes, and axioms, and is also implemented in the OWL language by the Protege open platform tools, taking into account existing standards and recommendations. In the structure of the ontology, the mathematical model is represented as branches of subclasses with the corresponding sets of attributes, characterized by their relationship to the higher-level model. Within this ontology, 17 types of relationships are presented. Applied ontology passed two stages of verification: structural - based on generally accepted estimates; logical - by testing queries and manually checking the correctness of the results. In particular, examples of model selection using an ontology for virtual sensors are given. The use of the proposed ontology in the structure of the management decision support subsystem increases the efficiency of these decisions, the validity of management actions and the efficiency of the technological component of the enterprise. Also, the ontology can be integrated into the ontology of industrial enterprises tasks or other domain ontologies.
Accumulation of Heavy Metals in Associated Irrigated Water, Soil and Production of Tomato around the Export Processing Zone of Bangladesh
Authors: Barua Prabal , Islam Md. Mazharul , Mitra Anisa
Published: July 2023

Present study assesses the uptake and allotment of heavy metals in irrigated water, soil and tomato (Lycopersicones culentum) at the export processing zone of Bangladesh. The elemental distributions of the heavy metals in the plant organs and fruits were determined after the harvesting stage. The uptake and distribution of the three heavy metals Cd, Cr and Pb were found in the several organs of tomato in reducing pattern of green tomato>plant shoot> leaf> ripen tomato> plant root; leaf> ripen tomato> plant shoot> plant root> green tomato and plant shoot> leaf> ripen tomato> plant root> green tomato while Ni has more toxic metal in Plant root but less in ripe tomato. This outline of distribution in the plant organ showed the typical pattern of a prohibited plant with a higher concentration of metals accumulated in the plant parts than in the fruits. The reducing pattern of the bio-concentration factor (BCF) showed that the ability of tomato fruits to accumulate heavy metals was reduced as the level of contamination in plant parts.
Laboratory Evaluation of Stabilising Components for Effective Treatment of Expansive Soil
Authors: Kanagarathinam L. , Govindaraj Venkatesan , Gokul V. , Muthukumaran V. , Sai Yalam Nikhil
Published: July 2023

The experimental study is to understand the mix ratio of fly ash and GGBS (ground granulated blast-furnace slag) in improving the shrink-swell characteristic of soil. The strength of the soil improved considerably after the addition of these stabilisers. In this study, experiments were conducted to observe the influence of the soil stabilisers in the improvement of the strength of the subgrade in expansive soil regions. This influential study will reveal the percentage of Flyash and GGBS mixture. Then the Standard Proctor Compaction test is used to determine the optimum moisture content required to compact the soil with Flyash and GGBS to attain the maximum dry density. The soil’s California Bearing ratio (CBR) was computed to understand the behaviour of improved soil if used as a subgrade. Hence the existing soil can be used as a subgrade with effective treatment of soil.
Comparison of Brain Amyloid Deposition and Cortical Glucose Metabolism Between Clinic- and Community-Based Cohort
Authors: Yabuuchi Kenichi , Kimura Noriyuki , Masuda Teruaki , Matsubara Etsuro
Published: July 2023

Background:

The differences in positron emission tomography (PET) imaging among older adults with mild cognitive impairment (MCI), according to the recruitment source, remain unclear.

Objective:

To investigate the differences in brain amyloid deposition and cortical glucose metabolism according to recruitment source among older adults with MCI.

Methods:

Participants in the clinic-based MCI cohort, who were referred to Oita University Hospital for cognitive decline, consisted of 90 adults with MCI. The community-based MCI cohort, which participated in a prospective cohort study, consisted of 118 adults with MCI. Participants underwent cognitive function evaluation, 11C-Pittsburgh compound B (PiB)-PET, and 18F-fluorodeoxyglucose (FDG)-PET. The prevalence of amyloid positivity and mean PiB and FDG uptake values were compared between the cohorts. Moreover, a voxel-by-voxel group study was performed to determine the areas with significant differences between the clinic- and community-based MCI cohorts.

Results:

The prevalence of amyloid positivity and mean PiB uptake value in the clinic-based MCI cohort were significantly higher than those in the community-based MCI cohort ( p < 0.001 and p < 0.001, respectively). The mean FDG uptake value in the clinic-based MCI cohort was significantly lower than that in the community-based MCI cohort ( p < 0.001). SPM 8 analysis showed significantly increased PiB uptake in the precuneus and parietotemporal lobe and significantly decreased FDG uptake in the posterior cingulate in the clinic-based MCI cohort compared to the community-based MCI cohort.

Conclusion:

The prevalence and severity of amyloid pathology in older adults with MCI varied depending on the recruitment source.
Generative adversarial network based data augmentation and quantum based convolution neural network for the classification of Indian classical dance forms
Authors: Jhansi Rani Challapalli , Devarakonda Nagaraju
Published: July 2023

The study addresses the challenges of human action recognition and analysis in computer vision, with a focus on classifying Indian dance forms. The complexity of these dance styles, including variations in body postures and hand gestures, makes classification difficult. Deep learning models require large datasets for good performance, so standard data augmentation techniques are used to increase model generalizability. The study proposes the Indian Classical Dance Generative Adversarial Network (ICD-GAN) for augmentation and the quantum-based Convolutional Neural Network (QCNN) for classification. The research consists of three phases: traditional augmentation, GAN-based augmentation, and a combination of both. The proposed QCNN is introduced to reduce computational time. Different GAN variants DC-GAN, CGAN, MFCGAN are employed for augmentation, while transfer learning-based CNN models VGG-16, VGG-19, MobileNet-v2, ResNet-50, and new QCNN are implemented for classification. The study demonstrates that GAN-based augmentation outperforms traditional methods, and QCNN reduces computational complexity while improving prediction accuracy. The proposed method achieves a precision rate of 98.7% as validated through qualitative and quantitative analysis. It provides a more effective and efficient approach compared to existing methods for Indian dance form classification.
A decision-making framework for classroom teaching quality evaluation of college badminton training with 2-tuple linguistic neutrosophic numbers
Authors: Chen Fu
Published: July 2023

How to guarantee the quality of college physical education (PE) teaching and reverse the declining trend of college students’ physique year by year has become a hot topic for the research of higher education and school PE workers. The quality assurance of higher education in China should give full play to the role of colleges in teaching quality assurance activities, constantly improve the level of school running and improve the efficiency of school running. Because colleges themselves are the main body of higher education and teaching activities, they have the most power, qualification and responsibility to explain the quality of higher education. The classroom teaching quality (CTQ) evaluation of college badminton training is regarded as multi-attribute decision-making (MADM). The 2-tuple linguistic neutrosophic sets (2TLNSs) which the truth-membership, indeterminacy-membership and the falsity-membership are assessed by using the 2-tuple linguistic term sets is an appropriate form to express the indeterminate decision-making information in the classroom teaching quality (CTQ) evaluation of college badminton training. In this paper, the Hamy mean (HM) and the power average (PA) are connected with 2-tuple linguistic neutrosophic sets (2TLNSs) to propose the 2-tuple linguistic neutrosophic numbers weighted power HM (2TLNWPHM) operator. Then, use the 2TLNWPHM operator to handle MADM with 2TLNS. Finally, taking the CTQ evaluation of college badminton training as an example, the proposed method is explained. The main contributions of this study are summarized: the establishment of the 2TLNWPHM operator; (2) The 2TLNWPHM operator was developed to handle MADM with 2TLNS; (3) Through the empirical application of the CTQ evaluation of badminton training in universities, the proposed method is validated; (4) Some comparative studies have shown the rationality of the 2TLNWPHM operator.
Studies related to employment of persons with intellectual disability: A systematic review
Authors: Jacob Udeme Samuel , Pillay Jace
Published: July 2023

BACKGROUND: There are still a lot of countries that do not provide employment opportunities to people with intellectual disability (ID). Ten years after the UN passed the Convention on the Rights of Persons with Disabilities, it is important to review existing studies on the employment of individuals with intellectual disabilities. OBJECTIVE: In this study, researchers reviewed studies that examined the employment of people with intellectual disability. METHOD: A thorough search of various bibliographic databases identified 1005 academic papers. Ten studies on the employment of persons with intellectual disabilities met the criteria for in-depth analysis. RESULTS: Employment is vital for individuals with intellectual disability, but predetermined employment options and parent-related factors may limit their access to the labour market. Efforts must be made to ensure a seamless progression from school to work. Lack of support makes bridging the gap between individual capacity and societal demands challenging. For people with intellectual disability to increase employment opportunities, stakeholders must work together. CONCLUSION: An intervention to support and follow up on older employees with intellectual disability will be greatly appreciated.
Facilitators and barriers of employment among transition-age Hispanic youth with disabilities
Authors: Castruita Rios Yazmin , Lee Beatrice , Umucu Emre , Estala-Gutiérrez Veronica , Kim Jaeyoung , Tansey Timothy
Published: July 2023

BACKGROUND: Prior research has examined the associations between demographic variables and employment outcomes in transition-age youth with disabilities, yet little is known about the supports and services that provide pathways to employment among transition-age Hispanic youth with disabilities. OBJECTIVE: The purpose of the study was to identify variables associated with employment for transition-age Hispanic youth VR participants. Among them, demographic factors, barriers to employment, services associated with exiting in competitive integrated employment and associated weekly earnings. METHODS: We used descriptive analysis to examine the demographic characteristics of the study’s sample. Variables were then dichotomized, except for age at application, to be analyzed via logistic regression and a stepwise forward regression analysis was performed to assess the association between different levels of independent variables and selected dependent variables. RESULTS: Findings were consistent with previous findings examining the relationships between sociodemographic variables, vocational rehabilitation (VR) related variables, and employment outcomes in transition-age youth with disabilities. Our findings revealed that there are several positive and negative sociodemographic and VR-related variables associated with employment and weekly earnings for transition-age Hispanic youth VR participants. CONCLUSION: Besides supporting transition-age Hispanic youth with disabilities, understanding familial perspectives and needs would also be critical in facilitating a successful employment experience.
The effectiveness of the model of occupational self-efficacy in improving the quality of life and self-efficacy beliefs in individuals living with schizophrenia: A pre- and post-intervention pilot study
Authors: Soeker Mogammad Shaheed , Abbas Iesrafeel , Karachi Farhana
Published: July 2023

BACKGROUND: Individuals diagnosed with schizophrenia often experience major limitations in returning to work despite participating in rehabilitation programs. OBJECTIVE: The aim of the study was to determine whether individuals who were diagnosed with schizophrenia experienced improved return to work rates, quality of life and self-efficacy beliefs after participating in an intervention program that utilizes the Model of Occupational Self-Efficacy (MOOSE). METHOD: Nine (n = 9) individuals who were diagnosed with schizophrenia participated in the study. The research study specifically utilized a pre- and post-intervention research design. In order to gather data from the participants, the WHO Quality of Life Questionnaire and Self-Efficacy Questionnaires were used to determine whether the individual living with schizophrenia’s quality of life and self-efficacy beliefs improved after participating in a vocational rehabilitation program. RESULTS: All participants in this study presented with an improvement in Return-to-Work Rates, Self-Efficacy Beliefs and Quality of Life scores. The results of the study revealed a 100% return to work rate, a statistically significant effect of the intervention (i.e., MOOSE) on Self-Efficacy beliefs, measured using the Generalized Self-Efficacy Scale, F(1, 8) = 6.606, p = 0.03.*. CONCLUSION: The findings of this study indicated that MOOSE is a useful model to facilitate the return to work of individuals living with schizophrenia. It is also suggested that cognitive rehabilitative activities, life skills and work skills training in a real work environment be included as part of the vocational rehabilitation program.
The usefulness of the Model of Occupational Self Efficacy (MOOSE) in returning stroke survivors to work in a rural community in Cape Town, South Africa
Authors: Soeker Mogammad Shaheed , Smith Melissa , Hess April Lucia
Published: July 2023

BACKGROUND: Individuals diagnosed with stroke have a poor return to work rate, particularly in rural communities. OBJECTIVE: The aim of the study is to describe the experiences and perceptions of individuals diagnosed with stroke about the usefulness of the Model of Occupational Self Efficacy (MOOSE) in assisting them in returning to their worker role. METHODS: The study utilized an explorative, descriptive, qualitative research design, furthermore the data was analyzed using thematic analysis, resulting in three themes. Seven stroke survivors and one key informant participated in the study. RESULTS: Theme one: Obstacles that affect the return to work of stroke survivors in a rural community. Theme two: Re-establishing a strong belief in functional ability through participation in occupation. Finally, theme three: The MOOSE enables transition to the worker role in a rural context. CONCLUSION: The findings indicate that the MOOSE is a useful model in facilitating the return to work of individuals diagnosed with a stroke. The participants struggled to return to work not only due to their loss of abilities but also their lack of knowledge with regard to how to return to work and their diagnosis of a stroke.
Guidelines to conduct research in computer-prompt software studies to decrease sedentary behaviors and increase physical activity in the workplace
Authors: Taylor Wendell C.
Published: July 2023

BACKGROUND: Computers are ubiquitous in the workplace and facilitate prolonged sitting, which has adverse health consequences. Various computer-prompt software programs are designed to decrease sedentary behaviors and increase physical activity in the workplace. However, specific guidelines that would improve research in this area have not been published. OBJECTIVE: The objective of this article is to present recommendations for improving computer-prompt software research, to decrease sedentary behaviors and increase physical activity in the workplace. METHODS: Ten domains were identified based on deficiencies in the current literature combined with quality assessment tools to reduce the risk for bias. The ten domains include composition of the research team, behavioral sciences theoretical frameworks, research design, alert types, outcome measures, confounding factors, intervention duration, carryover effects, racial/ethnic composition, and organizational culture. RESULTS: Specific recommendations are presented for each domain. The research team should include all stakeholders contributing as copartners in designing the intervention. For theory, a systems science framework was presented. Clustered randomized controlled trials were recommended, rather than randomization at the individual level. Distinct types of alerts (visual, auditory, or both) and frequency of alerts (hourly, randomly generated, or based on prolonged sitting patterns) are described. Outcome measures include average duration of sitting bouts, longest sitting bout, and number of sitting bouts. CONCLUSION: Prolonged sitting and physical inactivity at work lead to major health problems. Adherence to the recommendations presented here should facilitate high-quality research and improve the health of desk-based workers by decreasing sedentary behaviors and increasing physical activity.
ANALYSIS OF WAGE LEVELS DYNAMICS IN UKRAINE AND THE EU COUNTRIES AS A COMPONENT RESEARCH OF THE LABOUR MARKET CONDITIONS
Authors: Shevchuk Vladyslava
Published: July 2023

At the present stage of deepening the processes of Ukraine's European integration, studies of the state and prospects of development of the labour markets of Ukraine and the European Union countries are becoming increasingly relevant, since in recent years, according to some indicators of the labour market functioning, there has been a process of their separation (structural divergence), which has disintegration potential. In particular, one of the structural factors of their divergence is the imbalance in the field of remuneration.The article is devoted to the study and analysis of the dynamics of wages in Ukraine and the European Union as one of the components of the labour market research process. To achieve this goal, the author used a number of general scientific andspecial research methods interrelated and consistently applied in the work: the method of abstraction, theoretical generalisation, analysis and synthesis, induction, graphical and analytical method (graphs of dynamic changes in indicators).Based on a review of the minimum wages in the European Union, it is determined that in 2022 the EU countries will be divided into three groups: with a national minimum wage of more than EUR 1,500 per month; with a national minimum wage above EUR 1,000 but below EUR 1,500 per month; and with a national minimum wage below EUR 1,000 per month.It is established that the EU labour market has gender and cross-country imbalances in remuneration, while the Ukrainian labour market has gender and regional imbalances. It is determined that there are a number of global problems in the labour market. In the area of remuneration, these include low levels of minimum and average wages, excessive differentiation in remuneration in different regions and sectors of the economy, high and growing wage arrears, lack of connection between wages and the level of employee's qualifications and performance, and the existence of shadow remuneration schemes. The labour market conditions in Ukraine are of a falling type, as they are characterised by an excess of demand over supply (a decrease in vacancies and an increase in the number of unemployed) and a decrease in market prices (the real wage index)
STRATEGIC PLANNING OF THE DEVELOPMENT OFINLAND WATERWAY TRANSPORT ENTERPRISESBY DEVELOPING ANETWORK OF PORT HUBS
Authors: Boniar Svitlana , Budnyk Viktoriia
Published: July 2023

The purpose of the work was to form the principles of strategic planning for the development ofinland waterway transport enterprises by building a network of port hubs on the inland waterways of Ukraine.As a strategic goal in the system of strategic management of the activities of inland water transport enterprises of Ukraine, it is proposed to consider the creation of an effective logistics system of transportation and processing of goods by inland waterways as a result of the development of a network of multifunctional port hubs, terminal complexes and multimodal logistics centers on the basis of the integration of the efforts of all interested parties, namely: the state, shipowners and transport operators, river ports and owners of port terminals, as well as customers of services of inland waterway transport enterprises.The study systematizes the factors that characterize the advisability, attractiveness and efficiency of the participation of inland waterway transport enterprisesand producers of products transported and processed on inland waterways in the development of a network of river port hubs.The principles of strategic planning for the development of inland waterway transport enterprises as port hubs on the inland waterways of Ukraine were also formed, the main of which are: consideration of the functioning of the port hub as a whole as an object of strategic management; solidarity of the participants of the port hub's activities in order to achieve a common strategic goal; achieving a balance of the interests of the participants of the port hub regarding the amount of financing for the development of the hub, the level of prices and tariffs for services provided during transshipment and transportation of goods by inland waterways, and other aspects of the provision of services within the port hub.The use of the developed approaches to the strategic management of the development of the network of port hubs on the inland waterways of Ukraine will contribute to the attraction of cargo flows, the harmonization of the interests of both inland water transport enterprises and customers of cargo transportation and processing services, and the creation of conditions for ensuring the needs of the state economy and the ecologization of transportation
Myricetinin LNCaP Androjen Bağımlı Prostat Kanseri Hücreleri Üzerine Etkisinin Araştırılması
Authors: CESUR GÜNAY Özlem , SEÇME Mücahit
Published: July 2023

Prostat kanseri dünyada erkekler arasında en sık görülen ikinci kanser türüdür. Prostat kanserinin morbidite ve mortalitesi son zamanlarda artmıştır. Tedavisi için birçok alternatif yaklaşımlar geliştirilmeye çalışılsa da, prostat kanseri hala kötü prognoz sergilemekte ve yüksek ölüm oranları ile karşılaşılmaktadır. Myricetin, antikanser özelliği ile ilgi çeken doğal bir flavonoid bileşiktir. Yapılan in vitro ve in vivo çalışmalar myricetinin çeşitli mekanizmalar yoluyla prostat kanserini etkili bir şekilde inhibe ettiğini göstermektedir. Bu çalışmanın amacı artan dozlarda myricetin uygulamasının androjen reseptör bağımlı insan prostat kanser hücre hattı olan LNCaP hücrelerinin canlılığı üzerindeki etkilerini belirlemek ve apoptozla ilişkili BAX ve BCL2 genlerinin ekspresyon seviyelerini tespit etmektir. LNCaP hücreleri myricetinin 10 μM, 25 μM, 50 μM, 100 μM, 150 μM’lık konsantrasyonları ile 24 ve 48 saat süresince inkübe edilmiş ve hücre canlılığındaki değişimler 2,3-bis-(2-metoksi-4-nitro-5-sulfofenil)-2Htetrazolyum-5-karboksanilid (XTT) yöntemiyle belirlenerek IC50 değerleri hesaplanmıştır. BAX ve BCL2 gen ifadelerindeki değişimler ise Real-Time PCR metoduyla belirlenmiş ve elde edilen verilerin analizinde ΔΔCT metodu kullanılmıştır. Myricetinin uygulanan bütün dozlarda kontrole göre LNCaP hücre canlılığını azalttığı gösterilmiş olup IC50 değeri 24. saat için 123.76 μM, 48. saat için ise 84.79 μM olarak tespit edilmiştir. Ayrıca, myricetin uygulamasının apoptoz ilişkili BAX gen ifadesini istatistiksel olarak anlamlı bir düzeyde artırırken BCL2 gen ifadesini ise azalttığı görülmüştür. Myricetinin LNCaP hücrelerindeki antiproliferatif ve apoptotik etkileri daha detaylı olarak araştırılmalıdır.
Kronik Üveit Hastalığı Olan Çocuk ve Ailelerinin Hastalık ve Tedavi Sürecine İlişkin Yaşam Deneyimleri
Authors: Yanardağ Rauf , Özkan Yasemin , Yalçındağ F. Nilüfer
Published: July 2023

Bu araştırmanın amacı, kronik üveit hastalığı olan çocuklar ve ailelerinin hastalık tanısı, tedavi süreci ve yaşadıkları sorunlar hakkında anlatılarını incelemektir. Nitel yöntemin kullanıldığı bu araştırmanın çalışma grubu, 13 çocuk, 20 aile üyesi ve 13 sağlık profesyonelinden oluşmaktadır. Veriler her üç katılımcı grubuyla yapılan derinlemesine görüşmelerden elde edilmiştir. Verilerin çözümlenmesinde, Maxqda nitel veri analiz programı, teknik olarak da içerik ve tematik analiz tekniği kullanılmıştır. Bulgularda, çocukların eğitimlerinin aksadığı, fiziksel ve psiko-sosyal alanlarda sorunlar yaşadıkları, bir bütün olarak çocuk ve ailesinin iyilik halinin ve yaşam kalitesinin olumsuz etkilendiği öne çıkmıştır. Aile üyelerinin, çocuklarının görme yetisini kaybetme kaygısını yaşadıkları, psikososyal ve ekonomik olarak tükendikleri, bakım ve tedavi olanaklarına erişim, tedaviyi uygulama, toplumsal yaşamdan izole olma alanlarında sorunlar yaşadıkları tespit edilmiştir. Aile üyelerinin tüm bu sorunlarla baş etme stratejilerinde başta kadere sığınma, yaşananları imtihan olarak değerlendirme olmak üzere, sosyoeokonomik seviye, hasta yakınları arasında deneyim paylaşma, aynı gemide olma duygusu ön plana çıkmıştır. Sonuç olarak bir ailede kronik hastalığı olan bir bireyin olması, tüm aile sisteminin, rollerin, dengelerin değişmesine, sosyal ve ekonomik yaşamın derinden etkilenmesine, yani aile yapısının ve sosyal ilişkilerin yeniden yapılanmasına neden olmaktadır.
Case Report: Immune checkpoint inhibitor–induced multiorgan vasculitis successfully treated with rituximab
Authors: Qureshi Sehrish , Arani Naszrin , Parvathareddy Vishnu , Tchakarov Amanda , Abdelrahim Maen , Suarez-Almazor Maria , Zhang Jianjun , Gibbons Don Lynn , Heymach John , Altan Mehmet , Abudayyeh Ala
Published: July 2023

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. ICIs have a unique side effect profile, generally caused by inflammatory tissue damage, with clinical features similar to autoimmune conditions. Acute kidney injury from ICIs has been well studied; incidence ranges from 1% to 5%, with higher incidence when combination ICI therapies are used. Although the overall reported incidence of ICI-associated glomerulonephritis is less than 1%, vasculitis is the most commonly reported ICI-related glomerulonephritis. Other biopsy findings include thrombotic microangiopathy, focal segmental glomerulosclerosis, minimal change disease, and IgA nephropathy with secondary amyloidosis. We report a case in which a woman previously treated with the PD-L1 inhibitor durvalumab for locally advanced non-small cell lung cancer with pre-existing antineutrophil cytoplasmic (anti-PR3) antibody who later developed multi-organ vasculitis after ICI exposure, which was successfully treated with rituximab, with continued cancer remission for 3 years.
Allograft nephrectomy vs. no nephrectomy for failed renal transplants
Authors: McDonald Michelle
Published: July 2023

The role of allograft nephrectomy (AN) in failed renal transplants is a topic of debate, owing to controversial results reported in the literature and the fact that most of the studies are limited by a retrospective design and small numbers of participants. Allograft nephrectomy is most likely of benefit in the patient with recurrent allograft intolerance syndrome (AIS) following pulse steroids. Immunosuppression weaning in the presence of clinical signs related to a chronic inflammatory state is also reasonable grounds to pursue AN. Studies are mainly inconclusive but suggest that AN has no overall benefit for allograft survival after retransplant. This topic is still of interest in the transplant field and is particularly relevant for patients who are likely to require retransplantation within their lifetime. Further assessment is needed in the form of randomized controlled trials that control for various AN indications and immunosuppression regimens, and have clearly defined survival outcomes.
Factors explaining seasonal variation in energy intake: a review
Authors: Fujihira Kyoko , Takahashi Masaki , Wang Chunyi , Hayashi Naoyuki
Published: July 2023

Maintaining a balance between energy intake and expenditure is crucial for overall health. There are seasonal variations in energy intake, with an increase during spring and winter as well as a decrease during summer. These variations are related to a combination of environmental factors, including changes in temperature and daylight hours; social factors, including events and holidays; and physiological factors, including changes in physical activity and emotions. Accordingly, this review aimed to summarize the environmental, social, and physiological factors that contribute to seasonal variations in energy intake. A review of the current literature revealed that changes in temperature and daylight hours may affect eating behavior by altering homeostatic responses and appetite-related hormones. Additionally, increased participation in events and frequency of eating out, especially during winter vacations, may contribute to increased energy intake. Notably, these findings may not be generalisable to all populations since environmental and social factors can vary significantly depending on the local climatic zones and cultural backgrounds. The findings of the present review indicate that seasonal climate, events, and associated hormonal changes should be taken into account in order to maintain adequate energy intake throughout the year.