bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution of the meta-neurosurgeon: A systematic review of the current technical capabilities, limitations, and applications of augmented reality in neurosurgery
Authors: Sharma Nikhil , Mallela Arka N. , Khan Talha , Canton Stephen Paul , Kass Nicolas Matheo , Steuer Fritz , Jardini Jacquelyn , Biehl Jacob , Andrews Edward G.
Published: April 2024

Background:

Augmented reality (AR) applications in neurosurgery have expanded over the past decade with the introduction of headset-based platforms. Many studies have focused on either preoperative planning to tailor the approach to the patient’s anatomy and pathology or intraoperative surgical navigation, primarily realized as AR navigation through microscope oculars. Additional efforts have been made to validate AR in trainee and patient education and to investigate novel surgical approaches. Our objective was to provide a systematic overview of AR in neurosurgery, provide current limitations of this technology, as well as highlight several applications of AR in neurosurgery.

Methods:

We performed a literature search in PubMed/Medline to identify papers that addressed the use of AR in neurosurgery. The authors screened three hundred and seventy-five papers, and 57 papers were selected, analyzed, and included in this systematic review.

Results:

AR has made significant inroads in neurosurgery, particularly in neuronavigation. In spinal neurosurgery, this primarily has been used for pedicle screw placement. AR-based neuronavigation also has significant applications in cranial neurosurgery, including neurovascular, neurosurgical oncology, and skull base neurosurgery. Other potential applications include operating room streamlining, trainee and patient education, and telecommunications.

Conclusion:

AR has already made a significant impact in neurosurgery in the above domains and has the potential to be a paradigm-altering technology. Future development in AR should focus on both validating these applications and extending the role of AR.
Redefining cerebellar assessment: A comprehensive review of the cerebellum’s cognitive and affective roles and the efficacy of CCAS scales
Authors: Alan Albert , Ennabe Michelle , Alsarafandi Muath , Malik Noor , Laws Edward R. , Weinand Martin
Published: April 2024

Background:

Emerging research expands our understanding of the cerebellum beyond motor control to include cognitive, emotional, and autonomic functions. This review examines the cerebellum’s complex role, spotlighting Schmahmann’s syndrome, or cerebellar cognitive affective syndrome (CCAS), which impairs executive functions, language, and spatial processing. It emphasizes advancements in diagnosing CCAS and the imperative of developing superior diagnostic tools for managing cerebellar pathologies effectively.

Methods:

A comprehensive literature search was performed using databases such as PubMed, OVID Embase, and OVID Medline. Using the keywords “cerebellar cognitive, affective syndrome” and “Schmahmann syndrome,” the search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines for systemic review, in which the selection process narrowed down an initial set of 54 articles to 12, focusing on the impact of the CCAS scale on diagnosing and understanding Schmahmann’s syndrome.

Results:

The review’s analysis confirms the cerebellum’s roles in motor and cognitive functions and underscores the CCAS scale as a significant advancement in detecting cerebellar deficits, surpassing traditional assessments such as the mini-mental state examination and Montreal cognitive assessment.

Conclusion:

This review emphasizes the importance of understanding the cerebellum’s involvement in cognition and emotion and the crucial role of the CCAS scale for identifying cerebellar impairments. It calls for better diagnostic tools to assess CCAS accurately and suggests enhancing the CCAS Scale to reflect cultural and educational diversity. This will improve the diagnosis and treatment of cerebellar disorders, promoting a comprehensive neurological perspective on the cerebellum’s functions.
АНАЛИЗ ГЕОЭКОЛОГИЧЕСКОГО СОСТОЯНИЯ ТЕРРИТОРИИ В ЗОНЕ ДОБЫЧИ ГАЗА
Authors: Сарапулова Г.И. , Пыжьянов Д.И.
Published: April 2024

Выполнен геоэкологический анализ территории в зоне промплощадки нефтегазоконденсатного месторождения на основе ключевых параметров почвы. Выявлено закисление почвенного слоя (рН =4.2), а также значительное превышение содержание марганца. Изучены источники поступления загрязняющих веществ на почвы исходя из наличия промузлов.
ОПТИЧЕСКИЕ ИЗМЕРЕНИЯ В ПРОЦЕССЕ ПРОИЗВОДСТВА: КОНЦЕПЦИИ ТОЧНОЙ, БЫСТРОЙ И НАДЕЖНОЙ ОПТИЧЕСКОЙ МЕТРОЛОГИИ ДЛЯ СЛОЖНЫХ ИЗМЕРИТЕЛЬНЫХ СИТУАЦИЙ
Authors: Базарова А.М.
Published: April 2024

По состоянию на сегодняшний день оптическая метрология является важным элементом многочисленных производственных сфер. Лучше всего если подобные измерения осуществляются непосредственно во время производства, в соответствии со скоростью самого производственного процесса. При этом не имеет значения, насколько сложную форму имеют изготавливаемые детали и насколько они труднодоступны. Задачей современной оптической метрологии в процессе производства является создание способов проведения точных, быстрых и одновременно надежных измерений, независимо от сложности геометрической формы. Отдельные методы таких измерений можно наглядно продемонстрировать на примере тетраэдра оптических измерений. В зависимости от области применения, возможно использование методов, основанных на интерферометрии или геометрической оптике. В настоящей статье основное внимание уделяется важности повышения комплексности и надежности методов измерения.
Direct enthalpy measurement for hydrogenation of liquid organic hydrogen carriers by Differential Scanning Calorimetry under H2 pressure
Authors: D'Ambra Florian , Faucheux Vicent , Nicolas Emmanuel , Cantat Thibault , Gebel Gerard , HAJIYEV Parviz
Published: April 2024

In this contribution, we report the hydrogenation enthalpy direct measurement of well-studied Liquid Organic Hydrogen Carriers (LOHC) (Dibenzyltoluene, N-Ethylcarbazole, 2-Octanone) and of a new LOHC (Acetophenone) by differential scanning calorimetry (DSC) under H2 pressure. The obtained hydrogenation enthalpies showed good correspondence with DFT predictions and the literature. Moreover, multistep hydrogenation processes were investigated, evidencing that transfer hydrogenation occurred during the reaction. The study of bifunctional LOHC such as acetophenone and its derivatives showcased the potential of direct enthalpy measurement for rapid LOHC screening. Besides, a DFT correction factor for this specific bifunctional LOHC class was experimentally obtained, enabling more precise DFT predictions for similar systems. Kinetic parameters such as the activation energies for the catalytic Ru/Al2O3 system were also determined to be in the 45-60 kJ/mol range, compatible with the H2 adsorption on the Ru surface. The detrimental effect of steric hinderance was also observed. Finally, the reaction order in H2 was experimentally estimated to ~1 for all of the studied LOHCs.
Aliphatic Ketone Claisen Rearrangement: Troubleshooting the Transetherification Step by Identifying a Stable Acid Catalyst
Authors: Bruce Veera , Farshadfar Kaveh , Rolig Aino , Laasonen Kari , Pihko Petri
Published: April 2024

After optimization for catalyst stability, 4-chlorobenzoic acid emerged as the optimal catalyst for the aliphatic ketone Claisen rearrangement. The protocol enables a one-pot, metal-free, catalytic protocol from allylic alcohols to γ,δ-unsaturated ketones. The optimized process tolerates a range of substrates, including substituents with acid-labile protecting groups. Reaction monitoring and DFT studies of the aliphatic ketone Claisen process agree that the ultimate rearrangement step typically has the highest activation barrier.
Hyper-crosslinked polyphosphines as microporous macroligands for catalytic CO2 hydrogenation – a systematic study on structure-activity relations
Authors: Nisters Arne , Schleuning Steffen , Buntkowsky Gerd , Gutmann Torsten , Rose Marcus
Published: April 2024

Hyper-crosslinked polymers (HCPs) enable the tailored synthesis of functionalized materials and open up a versatile design strategy for porous macroligands. Based on the prototypical triphenylphosphine (PPh3) monomer, we investigate the roles of the involved crosslinking reagents on the formation of polyphosphines and evaluate structure-activity-relations for application in the catalytic CO2 hydrogenation: namely by varying the Friedel-Crafts catalyst, the crosslinker unit and the degree of crosslinking. The examination of the monomeric reactivities states the insufficient activation of the phosphine through iron chloride catalyzed crosslinking and the requirement for the stronger aluminum chloride to ensure PPh3 incorporation. Applying aromatic crosslinker units introduces porosity and promotes the accessibility of ligating centers for the immobilized ruthenium species. The thus formed solid catalysts exhibit excellent performances in the hydrogenation of CO2 to formic acid in the aqueous phase and are studied over consecutive recycling runs. The partial structural degradation of the frameworks during catalysis is addressed by adjusting higher degrees of crosslinking, leading to an improved stabilization of the catalyst. Overall, this study highlights crosslinking strategies for the tailored crafting of phosphine-based HCPs and the design of stable macroligands under catalytic conditions.
FragHub: A mass spectral libraries data integration workflow
Authors: Dablanc Axel , Hennechart Solweig , Perez Amélie , Cabanac Guillaume , Guitton Yann , Jamin Emilien , Lyan Bernard , Paulhe Nils , Giacomoni Franck , Marti Guillaume
Published: April 2024

Open mass spectral libraries (OMSL) are critical for metabolite annotation and machine learning, especially given the rising volume of untargeted metabolomic studies and the development of annotation pipelines. Despite their importance, the practical application of OMSLs is hampered by the lack of standardized file formats, metadata fields, and supporting ontology. Current libraries, often restricted to specific topics or matrices such as natural products, lipids, or the human metabolome, may limit the discovery potential of untargeted studies. FragHub addresses these challenges by integrating multiple OMSLs into a single comprehensive database, supporting various data formats and harmonizing metadata. It also proposes some generic filters for mass spectrum using a graphical user interface. Additionally, a workflow to generate in-house libraries compatible with FragHub is proposed. FragHub dynamically segregates libraries based on ionization modes and chromatography techniques, thereby enhancing data utility in metabolomic research. The FragHub Python code is publicly available under a MIT license, at the following repository: https://github.com/eMetaboHUB/FragHub. Generated data can be accessed at https://doi.org/10.5281/zenodo.11057687.
Automated exploration of the conformational degrees of freedom along reaction profiles - driving a FASTCAR
Authors: Gayraud Oscar , Courbière Bastien , Guégan Frédéric
Published: April 2024

This publication aims at presenting a Python-based workflow designed to enable a fully automatised and exhaustive exploration of the conformational degrees of freedom within the calculation of reaction paths in molecular systems. The proposed strategy focuses on effectively representing the lowest energy conformers for intricate, highly rotatable, and non-intuitive transition states, reagents and products, using existing computational tools. The article presents a workflow that is demonstrated through the application of three chemical reactions: a Diels-Alder reaction involving 4,4-dimethyl-3-methylenepent-1-ene and (E)-dec-5-ene, a diastereoselective intramolecular acid-catalysed cyclization reaction of an polycyclic azocane derivative and an enantioselective organo-catalysed Black rearrangement of benzofuran derivatives, which prove to be challenging to study "by hand". The proposed methodology is expected to be of a great help in the modelling of state-of-the art organic chemistry reactions, whose complexity is ever increasing.
Prevalence of denture induced oral mucosal lesions in removable denture wearers
Authors: Muhammad Fatah , Layla , Mahmud Saleh , Mahabad , S. Khalid , Sura , F. Alzubadee Ali
Published: April 2024

Background: Dentures can cause pathological problems to the oral tissues known as denture-induced mucosal lesions; the most common type is denture stomatitis.
Objective: To estimate the frequency of denture-induced mucosal lesions among denture wearer patients attending oral diagnosis clinic /Faculty of Dentistry in Tishk International University.
Patients and Methods: A patient who uses either removable partial or complete dentures was included. The patient’s gender and age, denture-related data, and oral lesions induced by dentures were evaluated. The data were statistically analyzed using chi-square and multivariate logistic regression.
Results: Oral lesions (23.5%) were more common in males; the lesions found include denture stomatitis, denture hyperplasia, traumatic ulcers, and angular cheilitis. Denture stomatitis was the most common type (7%). The correlation between vertical dimension state and oral lesions was very highly significant.
Conclusion: The major cause of denture-induced mucosal lesions was a change in denture vertical dimension and mostly a reduction in vertical dimension.
Book Review: ABD Hegemonyasına Meydan Okuma: Türk Dış Politikasında Otonomi Arayışı (1964-75)
Authors: Hazar Ayşe
Published: April 2024

Hüsna Taş Yetim tarafından yazılan ve 2023 yılında Lejand Kitap Yayın tarafından yayınlanan “ABD Hegemonyasına Meydan Okuma: Türk Dış Politikasında Otonomi Arayışı (1964-75)” başlıklı kitap, Türkiye-ABD arasında İkinci Dünya Savaşı sonrasında Sovyet tehdidi etrafında kurulan ve 1950’li yıllarda güçlü bir müttefiklik formu oluşturan ikili ilişkilerin, 1964-75 döneminde neden bir kriz evresine girdiğine ve Türkiye’nin bu kriz evresinde dış politikada otonomisini artırma yönündeki motivasyonlarının ne olduğuna yeni bir teorik bakış açısıyla açıklama sunar. 1950’lerde zirve yapan Türkiye-ABD ilişkileri, 1964 ve 1974’teki Kıbrıs Sorunu, 1967’deki haşhaş ekimi meselesi ve 1975’te ABD’nin silah ambargosu gibi olaylar nedeniyle 1964-75 döneminde bir dizi krizle karşı karşıya kaldı. Bu krizlerin hem bir nedeni hem de bir sonucu olarak Türkiye, 1975-78 yılları arasında ABD’nin üslerini kullanmasına kısıtlama getirdi ve dış politikasında otonomisini artıracak bazı kararlar aldı. Taş Yetim’in temel hedefi, ilgili tarih aralığında Türkiye-ABD ikili ilişkilerinde yaşanan krizlerin ve Türkiye’nin dış politika otonomisini arttırmaya yönelik girişimlerinin nedenlerini, hâkim literatüre göre yeni bir teorik bakış açısıyla analiz etmektir. Bu amaçla yazar, yakın zamanda uluslararası ilişkiler disiplinine dahil olan hiyerarşi teorisini temel alır ve bu teoriyi ittifak teorileri, dış politika analizi ve birey, devlet ve sistem düzeylerine odaklanan farklı teoriler ile destekler. Bu noktada odağına aldığı soru “Hiyerarşik bir düzenin muktedi devleti (subordinate state) neden dış politika otonomisini artırmaya yönelir?” (s.15) sorusudur. Soruyu Türkiye özelinde yeniden ifade etmek gerekirse, yazarın deyişiyle “1950’ler boyunca dış politika otonomisinin bir kısmını ABD’ye devreden Ankara, 1964-75 döneminde neden otonomisini artırmaya yöneldi? (s.25). Dolayısıyla Taş Yetim, teorileri harmanlayarak oluşturduğu üç ana hipotez ve dokuz alt hipotezle, hem 1950’lerde sıkı bir müttefiklik ilişkisi sergileyen Türkiye-ABD ilişkilerinin, 1960’lardan itibaren neden bir kriz döngüsüne girdiğini hem de Türkiye’nin dış politikada özerklik kazanmaya yönelik adımları neden attığını açıklar.
Fibroid uterus: A case study
Authors: Regitha Jales S.
Published: April 2024

Fibroid uterus, also known as Uterine leiomyoma, represents a common gynecological disorder affecting women, particularly those in their reproductive years. This paper presents a case study focusing on the clinical manifestation, diagnosis, management, and nursing care of a 43-year-old woman with fibroid uterus. Fibroids, benign neoplasms of the uterine wall, are classified based on their location within the uterus. Risk factors for fibroid development include early puberty, obesity, genetic predisposition, and oral contraceptive use. Diagnosis often involves ultrasound imaging, revealing characteristic features such as heterogeneous hypoechoic lesions. Management options range from medical to surgical interventions, with considerations for patient age, fertility preservation, and symptom severity. Surgical procedures like myomectomy and hysterectomy may be necessary, while non-surgical alternatives such as uterine artery embolism and myolysis offer alternatives. Nursing care focuses on pain management, nutritional support, infection prevention, and patient education. Early detection and appropriate management are essential to mitigate the risk of complications and preserve fertility in affected women.
Detection of genetically modified organisms by genetic markers in the local
market of Al-Muthanna Province-Iraq
Authors: Mandal A.M. , Alhasnawi A.N. , Jasim H.M. , Nurul S.M.T.
Published: April 2024

Genetically altered plants also called genetically modified organisms or GMOs, are
contentious subjects concerning food regulation. There are several challenges concerning
the potential dangers of GMOs' toxic, allergenic and dietary interactions. In this context,
sixty-seven food specimens were evaluated soybeans (Glycine max L. Merr), barley
(Hordeum vulgare L.), rice cereals (Oryza sativa L.), tomato (Lycopersicum esculentum
L.), Corn chips, maize (Zea mays L.), and potato (Solanum tuberosum L.) for GMO
content; these samples were obtained from Iraq, and DNA extraction was performed using
a test kit. DNA amplification was conducted using polymerase chain reaction (PCR);
subsequently, agarose gel and four primers were used to perform electrophoresis to
establish the presence of augmented GMO sequences. Experimental outcomes of 67
specimens indicated that 15 specimens tested positive; they comprised three samples each
of corn chips, rice, and maize, four soybean samples, and one sample for tomato and corn
seed using four primers. These results showed that GMO screening is a suitable technique
for detecting transgenic plants, testing and monitoring food specimens and controlling GM
levels in foods.
Strategy to reduce salt consumption in millennial generations using potato stick
snack as a food model: a study case in Indonesia
Authors: Fibri D.L.N. , Safira A.N. , Setiowati A.D. , Putro A.W.
Published: April 2024

High salt intake indicates high sodium consumption behavior in someone's diet then
possibly increases the risk of hypertension. The strategy needed to reduce salt
consumption by maintaining palatability and consumer acceptance in low-salt food.
Mushroom broth, an umami substance, is used as an alternative to improve the sensory
characteristics of lower salt products. In this study, a survey of salt consumption behavior
to identify the correlation between salt consumption with knowledge of salt and individual
characteristics (n=435) was carried out. Fifty panelists were recruited for sensory tests to
determine the threshold of salt concentration using snack as a food model. The hedonic
and palatability test using four samples with different levels of salt, each added with 0.5%
mushroom broth was carried out to evaluate the consumer acceptance of the mushroom
broth in a salt-reduced product. The results showed that there was no correlation (p>0.05)
in age, sex, body mass index, and knowledge of salt between salt consumption using the
Kendall Tau B test. Reducing salt up to a level of 25% in potato stick snacks was
achievable, without the panelists detecting a difference in taste and was still preferred.
Using 0.5% mushroom broth as a source of umami flavor was accepted by consumers to
replace the role of salt in food so it can act as an alternative strategy to reduce salt
consumption.
Antioxidant polypeptides derived from pigeon pea (Cajanus cajan (L) Mill sp.)
by enzymatic hydrolysis
Authors: Siriporn B. , Thongkorn P. , Waraporn S. , Wiriyaporn S. , Sinee S. , Chiramet A. , Aluko R.E.
Published: April 2024

Pigeon pea (Cajanus cajan (L) Mill sp.) seeds are rich sources of protein in the legume
family and their consumption has been associated with the prevention of noncommunicated diseases, which is attributable to their content of bioactive components.
Antioxidant protein hydrolysates were produced from pigeon pea protein isolate (PPI) by
enzymatic hydrolysis using pancreatin and flavourzyme. The hydrolysates were analyzed
for their physicochemical, molecular weight, amino acid composition, and in vitro
antioxidant activities. The molecular weights of polypeptides in the hydrolysates were 8,
20, 25 and 48 kDa, which were determined after pancreatin or flavourzyme hydrolysis of
the protein isolate for 4 h. Pancreatin-hydrolyzed pigeon pea protein (PPHP) contained
high hydrophobic amino acids, especially isoleucine, leucine and valine, which were
related to the high content of aromatic amino acids. The hydrolysates obtained from
flavourzyme hydrolysis of pigeon pea proteins (PPHF) presented significantly higher
capacities to scavenge ABTS˙+
and reduce Fe3 + better than that of PPI, while the PPI
exhibited strong DPPH scavenging (98.4 mg trolox equivalent antioxidant capacity). The
results indicated that the partial hydrolysis for PPI provided medium to high molecular
weight of peptides. Therefore, PPHF could be a promising source of bioactive peptides
and a potential ingredient for the formulation of functional foods against oxidative stress
Determinants of the Quality of the Accounting Information System at Pt Pegadaian (Persero) Se-Kab Bima
Authors: Hidayah Nur , Nurabiah
Published: April 2024

Purpose: This research aims to examine the determinants of the quality of the accounting information system at PT Pegadaian (Persero) in Bima Regency in an objective way.
Design/Methodology/Approach: The associative type with a quantitative approach is the one used in this research. This research was carried out in 30 Pegadaian (Persero) branches throughout Bima Regency. Primary data in this study was collected directly from respondents using a questionnaire survey. The partial least squares (PLS) method is a method tool used using SmartPLS software.
Findings: The results of this research show that there is an influence between organizational structure, organizational culture, and user competence on the quality of the accounting information system, but there is no influence between information technology on the quality of the accounting information system.
Implications/Originality/Value: These results provide an understanding of the factors that can improve the quality of information systems in companies.
Effectiveness of Public-Private Partnership Projects During the COVID-19 Pandemic
Authors: Fedorova E. A. , Gubanov A. A.
Published: April 2024

The purpose of the study is to assess the effectiveness of public-private partnership (PPP) projects during the COVID-19 pandemic, taking into account the specificities of the industry. The empirical research base included the main characteristics (contract price, federal district of the project, customer, general contractor, project start period, project start year, project deadlines, price reduction during project implementation, application security, contract security and type of activity) of 144 regional investment projects. The research methodology included mathematical modeling using the DEA (Data Envelopment Analysis) data convolution method, on the basis of which an efficiency index was assigned to each PPP project from 0 to 1. The study concluded that prior to the COVID-19 pandemic, regional investment projects received more funding; after the start of the COVID-19 pandemic, the implementation time of regional investment projects has increased, the contract value more often changes downwards during the project implementation; and the average support for a project application has increased. The efficiency of implementation of regional investment projects, calculated using the DEA method, was reduced. The results obtained will be useful to private investors and government authorities when implementing joint projects to improve their efficiency.
DAYAQ-HƏRƏKƏT APARATININ FUNKSİONAL VƏZİYYƏTİNİN DİNAMİKASI
Authors: Kh.H. Orujov  , R.M. Baghirova  , T.K. Hasanly
Published: April 2024

Dayaq-hərəkət sistemindəki pozğunluqların öyrənilməsi məqsədilə idmançılarda dayaq-hərəkət aparatının pozğunluqlarının bərpası üçün reabilitasiya proqramı işlənib hazırlanmış və elmi əsaslandırılmış, idmançılarda morfofunksional vəziyyətin yaratdığı dəyişikliklərə elmi əsas verilmişdir.
Sübut edilmişdir ki, dayaq-hərəkət sistemindəki pozğunluqların korreksiyası idmançılara erkən mərhələdə böyük təsir göstərir, çünki onun aradan qaldırılmasının gecikməsi bir çox hallarda dayaq-hərəkət aparatının disfunksiyasına səbəb olan geri dönməz vəziyyətlərə gətirib çıxarır. Nəticədə idmançıların dayaq-hərəkət sistemində əzələ və sümüklərdə struktur dəyişiklikləri, davamlı deformasiyalar və patoloji proseslər stimullaşdırılır. Dayaq-hərəkət aparatının pozğunluqları olan eksperimen-tal qrup idmançılarında onurğanın hərəkətliliyi, arxa və qarın əzələlərinin güc dözümlülüyü göstəriciləri baxımından motor sisteminin funksional vəziyyətinin dinamikası daha aydın nəzərə çarpır. Dayaq-hərəkət aparatının terapevtik tədbirlərindən sonra reabilitasiyada tətbiq olunan metodlar ənənəvi daha effektli olduğu məlum olmuşdur.
HЕYDƏR ƏLİYЕV АZƏRBАYCАNDА АLİ HƏRBİ TƏHSİLİ SİSTЕMİNİN YАRАDICISIDIR
Authors: E.S. Jabbarov  , E.K. Mеhdiyеv
Published: April 2024

. Аzərbаycаn xаlqının böyük mənəvi dəyərinə, ümid və аnd yеrinə çеvrilən xеyirxаh, vətənpərvər, yаrаdıcı, millətinin tərəqqisini hər şеydən ucа tutmаğı bаcаrаn, həyаtının hər аnı xаlqının tаlеyinə bаğlı оlаn, biоlоji yоxluğu mənəvi vаrlığı ilə əvəzlənən Ümummilli lidеr Hеydər Əliyеvin bütün sаhələrdə оlduğu kimi, оrdu quruculuğu sаhəsindəki xidmətləri də əvəzsizdir. Vətən mühаribəsindəki rəşаdətli qələbəsi ilə hərb tаrixinə öz аdını qızıl hərflərlə yаzаn qüdrətli Аzərbаycаn Оrdusunun qurucusu məhz Ulu öndər оlmuşdur: 70-ci illərdən bаşlаyаrаq bu istiqаmətdə аpаrdığı məqsədyönlü siyаsət, hərbi lisеyin və аli hərbi məktəbin yаrаdılmаsınа nаil оlmаsı, hərbi kаdrlаrın hаzırlаnmаsı sаhəsində görülən titаnik işlər, qаzаnılаn hərbi uğurlаr məhz оnun аdı ilə bаğlıdır. Qürurvеrici hаldır ki, bu gün Аzərbаycаn Silаhlı Qüvvələri yаlnız ərаzilərimizin qоrunmаsındа dеyil, həm də bеynəlxаlq təhlükəsizliyin təmin оlunmаsındа fəаl iştirаk еdir, оrdumuzun uğurlа həyаtа kеçirdiyi əməliyyаtlаr аpаrıcı dövlətlərin hərbi mütəxəssisləri tərəfindən təhlil еdilir, öyrənilir.
Desafíos y retos de la movilidad sustentable en el mundo contemporáneo
Authors: de la Cultura División de Extensión
Published: April 2024

En un sentido filosófico, la movilidad se soporta en el liberalismo clásico definido como la tradición ética, política, legal y económica, que coloca a la libertad individual al centro y la concibe como el derecho de cada individuo de disponer de su persona, acciones y posesiones, para realizar sus elecciones dentro del marco legal del lugar en donde se encuentra, sin estar sujeto a la arbitrariedad de alguien más (Palmer, 2010).
Üniversite Öğrencilerinde Anne-Baba Bağışlama Algısı ve Kişisel Bağışlama Düzeyleri İlişkisi
Authors: Erdemir Nuri , Durmuş Emine
Published: April 2024

Amaç: Bu çalışmada, algılanan anne baba bağışlama düzeyinin, bireylerin bağışlama alt boyutları; kendini bağışlama, başkalarını bağışlama, durumu bağışlama düzeyleri arasındaki ilişki incelenmiştir.
Yöntem: Araştırmanın verileri Heartland Affetme ölçeği ile ve kişisel bilgi toplama formu ile elde edilmiştir. Bu araştırmada yöntem olarak ilişkisel tarama yöntemi kullanılmıştır. Araştırmanın örneklemini katılmayı kabul eden gönüllü 325 kadın (%71,9) ve 127 erkek (%28,1) olmak üzere toplam 452 üniversite öğrencisi oluşturmaktadır.
Bulgular: Cinsiyet ile kendini, başkalarını ve toplam bağışlama ölçeği puanları arasındaki fark anlamlı bulunmamıştır. Fakat cinsiyetin durumu bağışlama üzerinde test puan ortalamaları arasındaki fark anlamlıdır. Algılanan anne bağışlama ifadeleri puanına göre bağışlama ölçeği puanları arasındaki fark anlamlı bulunmamıştır. Algılanan baba bağışlama ifadeleri puanına göre bağışlama ölçeği puanları arasındaki fark anlamlı bulunmamıştır. Ayrıca araştırmada algılanan anne baba bağışlama ifadelerinde bireylerin anneleri daha bağışlayıcı babaları ise daha az bağışlayıcı buldukları dikkat çekmiştir.
Sonuçlar ve Öneriler: Benzer bir çalışma, başka örneklem grupları ile yapılabilir ve araştırma sonuçları karşılaştırılabilir. Algılanan anne baba bağışlama düzeyleri ile bireysel bağışlama düzeylerinin araştırılması yerine anne baba bağışlama düzeyi ile bireysel bağışlama düzeyleri araştırılabilir.
Registro de miembros de la Asociación de Pacientes con Angioedema Hereditario de Perú
Authors: Calderón LLosa Oscar Manuel , Muñoz Campos Danny , Olivares Gómez Margarita
Published: April 2024

Introduction:Hereditary Angioedema (HAE) is a rare disease characterized by episodes of swelling, HAE crisis could cause death by suffocation, also affect the quality of life in these patients, In Perú there are 33 million inhabitants, according to the worldwide prevalence (1:50,000) it is estimated that there could be approximately 700 patients with HAE C1-Inhibitor.Our main objective is to report the registry of the HAE Peruvian patient’s association.Material and methods: We used the questionnaire of the Latin American HAE committee. Consent was requested from the patient’s association to report the data.Results: We report data of 63 patients, 51 Female, 12 Male, range age between 6 to 74 years. Nine under 18 years old, 5/9 between 6 to 13 years. Forty-five HAE C1-INH type I, 12 HAE-FXII, 5 HAE UNK, 1 AAE. Symptoms onset average age in 56/62 HAE patients was 16.8. In a group of 50/62 adult HAE patients the average diagnostic delay approximately was 19.3 years.Laboratory tests: we can perform C4 complement C1-inhibitor antigenic and functional tests.Treatments: The patients have access to tranexamic acid (TA) and attenuated androgens. We do not have registered specific long-term prophylaxis treatments. We used moderate/high doses of TA, in most patients up to 6 gr i.v./in 24 hours, we start with the treatment immediately the HAE acute crisis is beginning, it helps to the HAE attacks are less symptomatic, resolves in a few days and decrease the frequency.
Conclusions: We present 63 members of the Association of Patients with Hereditary Angioedema of Perú. We have improved blood test for HAE diagnosis. Moderate and high doses of Tranexamic Acid are used for prophylaxis and acute crisis respectively, with acceptable response. No deaths have been reported due to HAE crisis in the patient's association.
Frecuencia de sensibilización a camarón con inmunoterapia a ácaros con extractos polimerizados
Authors: Giraldo Paola , Diez Susana , Lopera Maria , Alzate Leidy , Villarreal Gilma , Caraballo Ana Lorena , Carmona Sandra , Osorio Laura , Yepes Maria , Sanchez Jorge
Published: April 2024

This work corresponds to one of the abstracts of the XIV Colombian Congress of Allergy, Asthma and Immunology and the VI Meeting of the Colombian Association of Immunology.
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Authors: Ahumada Velky , Peña Nayelys , Herrera Nestor , Urrego Juan
Published: April 2024

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Medición de citoquinas mediante una técnica multiplex por citometría espectral: aplicación en el estudio de la inmunobiología de la ascariasis
Authors: Lozano Ana , Sánchez-Marrugo Carolina , Llinás-Caballero Kevin , Barrios Carlos , Acevedo Nathalie , Zakzuk Josefina , Caraballo Luis
Published: April 2024

Introduction: The multiplex technique for cytokine measurement using flow cytometry offers the advantage of lower sample requirements than other methods such as enzyme-linked immunosorbent assay (ELISA). Although most of these assays are standardized on specific cytometers and software, it is important to assess their applicability to other equipment and open-source software, such as R, to expand their usage.
Objectives: To quantify the production of Th1/Th2/Th17 cytokines induced by Ascaris lumbricoides antigens in peripheral blood mononuclear cells (PBMCs) using a multiplex technique.
Methods: PBMCs were cultured from individuals with mild A. lumbricoides infection (n = 20) and uninfected individuals (n = 21) and stimulated with A. lumbricoides extract (ExtAscaris), a mix of anti-CD2/CD3/CD28 (CDmix) as a positive control, and only medium (negative control). Cytokines in the supernatants were measured using the BD™ Cytometric Bead Array Human Th1/Th2/Th17 kit, to identify IFN-γ, TNF, IL-10, IL-6, IL-4, IL-2, and IL-17A. Readings were taken on a spectral cytometer (Northern Lights, Cytek, USA), and analysis was performed using R software with packages "tidyverse," "beadplexr," "flowCore," and "arsenal." Cytokine concentrations were calculated using a 5-parameter logistic curve. The t-test was used to compare cases and controls, and statistical significance was set at p < 0.05. The study was approved by the Ethics Committee of the University of Cartagena and the participants provided informed consent. This study was financially supported by the Colombian Sistema General de Regalías under the BPIN2020000100405 - BPIN2020000100364.
Results: Efficient fluorescence intensity extraction for each cytokine was achieved using detection channel R8 and the "mclust" clustering model (Figure 1). No significant differences were found in the levels of the seven cytokines between cases and controls (Figure 2). Although the IFN-γ response to ExtAscaris was higher in cases than in controls (252.5 ng/mL vs. 173.1 ng/mL), the difference was not significant. IL-17A (detection limit: 18.9 pg/mL) was more detectable in cases than controls (5 cases, 23% vs. 2 controls, 9.5%). IL-4 was only detected in the supernatants from CDmix-stimulated cultures but not with the Ascaris extract (Figure 2).
Conclusions: The multiplex technique using spectral flow cytometry combined with open-source software analysis proved applicable for quantifying cytokines induced by A. lumbricoides antigens in PBMCs. However, a more sensitive method is needed to evaluate IL-4 response in the context of ascariasis. The results did not reveal significant differences in cytokine production between cases and controls for the evaluated stimuli.
Nuevos epítopes B y T, consenso de tropomiosina involucradas en reactividad cruzada entre diez especies diferentes. Un estudio in silico
Authors: Fang Luis , Martínez Dalgys , Meza-Torres Catherine , Moreno-Woo Ana , Pereira-Sanandres Nicole , Domínguez-Vargas Alex , Garavito Gloria , Egea Eduardo
Published: April 2024

Introduction: tropomyosin is a pan-allergen that shows cross-reactivity between different species. In tropical countries, allergy to arthropods (mites, shrimp, cockroaches, mosquitoes) or nematodes (Ascaris spp) is common. IgE epitopes of tropomyosin may be the source of sensitization and the development of allergic symptoms. However, T epitopes (MHC-II) polarize the Th2 response.
Objective: This study aimed to identify by in silico methods tropomyosin consensus B and T epitopes of shrimp species, house dust mites, insects, and nematodes associated with allergic diseases in tropical countries.
Methods: in silico analysis included tropomyosin from mites (Der p 10, Der f 10, Blo t 10), insects (Aed a 10, Per a 7, Bla g 7), shrimp (Lit v 1, Pen m 1, Pen a 1), and nematode (Asc l 3); all sequences were taken from the UniProt database. Linear IgE epitopes were predicted with AlgPred 2.0 and validated with BepiPred 3.0. MHC-II binding T cell epitopes were predicted using the IEDB server, which implements nine predictive methods (consensus method, combinatorial library, NN-align-2.3, NN-align-2.2, SMM-align, Sturniolo, NetMHCIIpan -3.1, and NetMHCIIpan -3.2) these predictions focused on 10 HLA-DR and 2 HLA-DQ alleles associated with allergic diseases. Subsequently, consensus B and T epitopes present in all species were identified. 
Results: we identified 12 sequences that behaved as IgE-epitopes and B-cell epitopes, three of them: 160RKYDEVARKLAMVEA174, 192ELEEELRVVGNNLKSLEVSEEKAN215, 251KEVDRLEDELV261 were consensus in all species. Eleven peptides (T-epitopes) showed strong binding (percentile rank ≤ 2.0) to HLA-DRB1*0301, *0402, *0411, *0701, *1101, *1401, HLA- DQA1*03:01/DQB1*03:02, and HLA- DQA1*05:01/DQB1*02:01. Only two T-epitopes were consensus in all species: 167RKLAMVEADLERAEERAEt GEsKIVELEEELRV199, and 218EEeY KQQIKT LTaKLKEAEARAEFAERSV246. Subsequently, we identified 2 B and T epitope sequences and reached a consensus between species 167RKLAMVEA174 and 192ELEEELRV199.
Conclusions: These data describe three sequences that may explain the IgE cross-reactivity between the analyzed species. In addition, the consensus B and T epitopes can be used for further in vitro investigations and may help to design multiple-epitope protein-based immunotherapy for tropomyosin-related allergic diseases.
EPIDEMIOLOGIA DOS ACIDENTES COM SERPENTES NO BRASIL
Authors: Costa Antonio Samuel Da Silva , Carvalho Mateus De Oliveira , Oliveira João Gabriel dos Santos , Andrade Micássio Fernandes de
Published: April 2024

Trata-se de um resumo simples que aborda a epidemiologia dos acidentes com serpentes no Brasil, que utiliza o dados do DATASUS como fonte. Nesse sentido foram utilizados os dados a partir de 2018.
Desafio na intervenção precoce e gerenciamento de emergências dermatológicas graves; Necrólise epidérmica tóxica e Stevens-Johnson
Authors: Schmidt Rosana Maciel , Barboza Nicoly de Oliveira , Possobon Mariana da Silva , Zago Matheus , Daumichen Cinthia Sousa , Silva Natalia Magagnin , Teixeira Maycon Gabriel Duarte , Campagnolo Orley Alvaro , Hoss Louise Etienne , Santos Karoline Mieczikowski Dos
Published: April 2024

A síndrome de Stevens-Johnson (SSJ) e a necrólise epidérmica tóxica (NET) são reações mucocutâneas, potencialmente fatais, desencadeadas habitualmente por medicamentos, como sulfonamidas e anticonvuls
I Will Meet You There, and We Can Be Anxious Together: The Lived Experiences of College Students with Anxiety Disorders
Authors: Dickerson Whitney , Nelson Timothy Reid
Published: April 2024

The purpose of this qualitative transcendental phenomenological study was to understand the essence of the shared lived experiences of undergraduate college students with anxiety disorders at two universities in the Southeastern United States. Ellis’s cognitive theory, rational emotive behavior therapy, guided the study which took place at a mid-sized, public nonsectarian university and a small, private liberal arts college. The central research question elicited rich data regarding the shared lived experiences of the study participants. The four research sub-questions address participants’ perceptions regarding the impact of their disorders on their lifestyles and academic performance. A purposeful criterion sample was used to select the participants who completed a questionnaire, open-ended individual interviews, a single focus group interview, and participant journals. Phenomenological reduction was used to create a composite integration of meaning and the essence of the lived experience of the participants. Data results identified five themes: (a) social fears, (b) stressor issues, (c) generational issues, (d) academic performance barriers, and (e) institutional education and accommodation preferences.
Temephos Resistance Status of Aedes aegypti Populations From Havana, Cuba
Authors: Piedra Luis A. , Martinez Yanisley , Camacho Eric , Garcia Israel , Rodriguez Dayana , Vanlerberghe Veerle , Marquetti Maria Del Carmen
Published: April 2024

Aedes aegypti chemical control remains an indispensable alternative to prevent dengue, Zika, and chikungunya outbreaks in Havana, Cuba. The city of Havana requires constant surveillance because of its bioecological characteristics that favor the proliferation of mosquito vectors of these viruses, which constitutes a high risk to the health of its inhabitants. The goal of this study was to determine the impact of the stopping of temephos applications during the 2 years of the COVID-19 pandemic on the level of susceptibility of Ae. aegypti in 5 municipalities of Havana, Cuba. Larval susceptibility was evaluated by bioassays as described by the World Health Organization. All Ae. aegypti populations tested showed high resistance to temephos. The National Control Program of Ae. aegypti in Cuba will need to promote insecticide rotation policies to prevent the evolution of temephos resistance in Havana.
Unorthodox: Muhalif Bir Tipin Kimlik Arayışı Üzerine Sosyolojik Değerlendirme
Authors: Ayhan Döne
Published: April 2024

Gündelik hayatın kalıplarını ve değerlerini farklı tipolojiler üzerinden görmek mümkündür. Bu noktada toplumsal yapının dinamiklerini anlamak ve anlamlandırmak için görsel sosyoloji önemli ip uçları sunmaktadır. Film ve dizilerde kullanılan görsel imgeler top-lumsal arka planın anlaşılmasında işlevseldir. Toplumsal yapının görselleşmesinde mekan ve kültür değişimi, toplumsal tipolojiler, kimlik süreçleri ve zamansal öğeler sıklıkla konu edilmektedir. Toplum analizinde en hızlı ve kolay yol çoğu zaman tipolojilerin kavranmasından geçmektedir. Çünkü toplumsal tipolojiler bir toplumun kültürel baki-yesini aksettirmektedir. Toplumun sosyalleşme pratiklerinin anlaşılmasında toplumsal tipolojiler yadsınamaz bir gerçekliktir. Alışılmışın dışında bir kimlik ve zihniyeti temsil eden “muhalif” toplumsal tipolojisinin izlerinin anlaşılmaya çalışıldığı bu çalışmada, Un-orthodox dizisi özelinde muhalif bir tipin kimlik inşa sürecinin incelenmesini amaçlanmak-tadır. Muhalif bir tipolojinin gündelik hayatı anlamlandırması ve kültürel izleri çalışmanın odağıdır. Muhalif tipolojisinin var oluş sürecinin anlaşılması adına değişim pratikleri keşfedilmeye çalışılmıştır. Nitel araştırma yöntemiyle ele alınan çalışmada doküman inceleme veri toplama yöntemi kullanılarak betimsel analizle değerlendirilmiştir. Muhalif tipi ve kimlik kapsamına girebilecek “aile ve cemaate karşı kadının duruşu”, “muhalif tipolojisinin görünümü”, “aidiyet arayışı” ve “kimlik inşa süreci” gibi temalar bulunmuştur. Bu çerçevede muhalifin sosyokültürel ve mekânsal ilişkiler ekseninde analiz edilmiştir. Kural ve sınırlara uymayan bir kültür ve zihniyeti gerekli kılan muhalifin sosyal ilişki form-ları ve kimlik edinme stratejisi yeniden üretilmektedir.
Heavy metal content in dumpsite soils and vegetables: A case study of Ondo Town, Nigeria
Authors: Abata Emmanuel Orimisan  , Adunbi John Olarewaju  , Babafemi Raphael Babaniyi  , Ajayi Olubode Olumuyiwa
Published: April 2024

The investigation scrutinized the levels and distribution of five heavy metals (iron, cadmium, copper, lead, and nickel) at two dumpsites (Site A and Site B) and a control zone in Ondo Town, Nigeria. Moreover, the examination assessed the presence of these heavy metals in vegetable plants (Talinum triangulare and Chromolaena odorata) commonly encountered in these areas, employing atomic absorption spectrophotometry (Buck AAS 210 VGP). Conventional methodologies were utilized to evaluate specific soil physicochemical characteristics. In the control region, minimal levels of each metal were identified, with the exception of nickel. The quantities of metals varied, with lead at 0.02 mg/kg in the control area and iron at 3.54 mg/kg in Site A. The metal levels in both soil and vegetables investigated generally remained below the maximum thresholds established by the World Health Organization (WHO) for soil and vegetables, except for cadmium in Site A. The dumpsites and the associated vegetables displayed elevated levels of the heavy metals in comparison to the control area, suggesting a gradual accumulation of these metals in the vegetable flora. Hence, the consumption of vegetables cultivated near the examined sites and the use of these areas for agricultural activities should be discouraged.
Gaming habits, cognitive flexibility and sleep quality among gamers
Authors: Jeslin Elsa Jose  , Sampreeti Das
Published: April 2024

In the modern era, gaming has emerged as a predominant recreational activity among young adults, prompting an examination into its impact on cognitive flexibility and sleep quality. The aim of the study was to assess the impact of gaming habits on cognitive flexibility and sleep quality among gamers and to understand the relationship between them. The study was conducted among individuals ranging from 18-26 of age range. The study used a convenient sampling method and data from 150 gamers were collected and analyzed utilizing statistical methodologies such as Spearman’s correlation and Simple Linear Regression using IBM SPSS. The study uncovered significant correlations between gaming habits and both cognitive flexibility and sleep quality. Furthermore, it revealed a positive association, indicating that gaming habits have a positive influence on both cognitive flexibility and sleep quality. These findings provide valuable insights for taking initiatives aimed at promoting balanced gaming behaviors and enhance awareness about the importance of maintaining optimal sleep hygiene practices in gaming communities.
Overview of Dengue Fever (DHF) incidence based on population density in Indonesia
Authors: Hildah Awalussiyam  , Lucia Yovita Hendrati
Published: April 2024

Dengue fever (DHF) is an infectious disease caused by the dengue virus, with Aedes aegypti and Aedes albopictus mosquitoes as vectors. The prevalence of DHF globally has increased significantly, and the infection has become endemic in many regions including Indonesia. The purpose of this study was to determine the relationship between population density and the incidence of Dengue Hemorrhagic Fever (DHF) in Indonesia. This research uses a descriptive method with a population correlation study. Descriptive analysis in this study utilized the Health Mapper version 4.3.0.0 application while the population correlation test used the SPSS data processing application with the Spearman bivariate test. The population in this study is provinces in Indonesia. The independent variable in this study is population density in provinces in Indonesia, while the dependent variable in this study is the incidence of Dengue Fever (DHF) in Indonesia in 2020, 2021, and 2022. The results showed that DHF cases are directly proportional to the high population density in a province. The correlation test on dengue cases and Indonesia's population density in 2020 showed a correlation coefficient of 0.811. The correlation test between DHF cases and Indonesia's population density in 2021 showed a correlation coefficient of 0.766. The correlation test between dengue cases and Indonesia's population density in 2022 showed a correlation coefficient of 0.741. This study concluded that there is a very strong relationship between dengue fever cases and population density in various regions in Indonesia.