bluuebunny/crossref_metadata_2025 huggingface dataset:
Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe
Authors: Nowotny Hanna , Neumann Uta , Tardy-Guidollet Véronique , Ahmed S Faisal , Baronio Federico , Battelino Tadej , Bertherat Jérôme , Blankenstein Oliver , Bonomi Marco , Bouvattier Claire , Brac de la Perrière Aude , Brucker Sara , Cappa Marco , Chanson Philippe , Claahsen-van der Grinten Hedi L , Colao Annamaria , Cools Martine , Davies Justin H , Dörr Helmut-Günther , Fenske Wiebke K , Ghigo Ezio , Giordano Roberta , Gravholt Claus H , Huebner Angela , Husebye Eystein Sverre , Igbokwe Rebecca , Juul Anders , Kiefer Florian W , Léger Juliane , Menassa Rita , Meyer Gesine , Neocleous Vassos , Phylactou Leonidas A , Rohayem Julia , Russo Gianni , Scaroni Carla , Touraine Philippe , Unger Nicole , Vojtková Jarmila , Yeste Diego , Lajic Svetlana , Reisch Nicole
Published: March 2022

Objective

To assess the current medical practice in Europe regarding prenatal dexamethasone (Pdex) treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency.

Design and methods

A questionnaire was designed and distributed, including 17 questions collecting quantitative and qualitative data. Thirty-six medical centres from 14 European countries responded and 30 out of 36 centres were reference centres of the European Reference Network on Rare Endocrine Conditions, EndoERN.

Results

Pdex treatment is currently provided by 36% of the surveyed centres. The treatment is initiated by different specialties, that is paediatricians, endocrinologists, gynaecologists or geneticists. Regarding the starting point of Pdex, 23% stated to initiate therapy at 4–5 weeks postconception (wpc), 31% at 6 wpc and 46 % as early as pregnancy is confirmed and before 7 wpc at the latest. A dose of 20 µg/kg/day is used. Dose distribution among the centres varies from once to thrice daily. Prenatal diagnostics for treated cases are conducted in 72% of the responding centres. Cases treated per country and year vary between 0.5 and 8.25. Registries for long-term follow-up are only available at 46% of the centres that are using Pdex treatment. National registries are only available in Sweden and France.

Conclusions

This study reveals a high international variability and discrepancy in the use of Pdex treatment across Europe. It highlights the importance of a European cooperation initiative for a joint international prospective trial to establish evidence-based guidelines on prenatal diagnostics, treatment and follow-up of pregnancies at risk for CAH.
Biallelic POC1A variants cause syndromic severe insulin resistance with muscle cramps
Authors: Mericq Veronica , Huang-Doran Isabel , Al-Naqeb Dhekra , Basaure Javiera , Castiglioni Claudia , de Bruin Christiaan , Hendriks Yvonne , Bertini Enrico , Alkuraya Fowzan S , Losekoot Monique , Al-Rubeaan Khalid , Semple Robert K , Wit Jan M
Published: March 2022

Objective

To describe clinical, laboratory, and genetic characteristics of three unrelated cases from Chile, Portugal, and Saudi Arabia with severe insulin resistance, SOFT syndrome, and biallelic pathogenic POC1A variants.

Design

Observational study.

Methods

Probands’ phenotypes, including short stature, dysmorphism, and insulin resistance, were compared with previous reports.

Results

Cases 1 (female) and 3 (male) were homozygous for known pathogenic POC1A variants: c.649C>T, p.(Arg217Trp) and c.241C>T, p.(Arg81*), respectively. Case 2 (male) was compound heterozygous for p.(Arg217Trp) variant and the rare missense variant c.370G>A, p.(Asp124Asn). All three cases exhibited severe insulin resistance, acanthosis nigricans, elevated serum triglycerides and decreased HDL, and fatty liver, resembling three previously reported cases. All three also reported severe muscle cramps. Aggregate analysis of the six known cases with biallelic POC1A variants and insulin resistance showed decreased birth weight and length mean (s.d.): −2.8 (0.9) and −3.7 (0.9) SDS, respectively), severe short stature mean (s.d.) height: −4.9 (1.7) SDS) and moderate microcephaly (mean occipitofrontal circumference −3.0 (range: −4.7 to −1.2)). These findings were similar to those reported for patients with SOFT syndrome without insulin resistance. Muscle biopsy in Case 3 showed features of muscle involvement secondary to a neuropathic process.

Conclusions

Patients with SOFT syndrome can develop severe dyslipidaemic insulin resistance, independent of the exonic position of the POC1A variant. They also can develop severe muscle cramps. After diagnosis, patients should be regularly screened for insulin resistance and muscle complaints.
Improving Pneumococcal Vaccination Rates in High-risk Children in Specialty Clinics
Authors: Harris Julia G. , Harris Luke A. , Olarte Liset , Elson E. Claire , Moran Rachel , Blowey Douglas L. , El Feghaly Rana E.
Published: March 2022

BACKGROUND AND OBJECTIVES

Pediatric patients with immunocompromising or certain chronic medical conditions have an increased risk of acquiring invasive pneumococcal disease (IPD). The 23-valent pneumococcal polysaccharide vaccine (PPSV23) is recommended for patients ≥2 years at high risk for IPDs. The aim of this project was to improve PPSV23 vaccination rates for children at high risk for IPD who were seen in 3 specialty clinics from ∼20% to 50% over a 12-month period.

METHODS

The project team included quality improvement champions from the divisions of rheumatology, infectious diseases, and pulmonology in addition to leaders from our population health management subsidiary. Several initiatives were implemented, starting with review of patient inclusion criteria per the vaccination recommendations, that led to the design and deployment of an automated weekly previsit planning report. Additionally, we implemented a process to stock pneumococcal vaccines and shared best practices among the divisions. We monitored improvement through times series and run charts of PPSV23 vaccination rates.

RESULTS

The initial PPSV23 vaccination rate for applicable high-risk patients was ∼20%. There was an increase in vaccination rate to ∼60%. All 3 divisions showed improvements in their individual PPSV23 vaccination rates.

CONCLUSIONS

Using quality improvement methodology, we increased PPSV23 vaccination rates in 3 pediatric specialty clinics, and this improvement was sustained. We will continue to identify best practices and actively recruit additional divisions because we have the opportunity to reach >9000 high-risk patients.
DETECCIÓN Y CARACTERIZACIÓN MOLECULAR DEL POTATO VIRUS B (PVB) EN CULTIVOS DE PAPA CRIOLLA (Solanum phureja) EN ANTIOQUIA
Authors: GIRALDO RAMÍREZ SUSANA , SIERRA MEJÍA ANDREA , OSPINA ORTIZ MARIA ISABELLA , HIGUITA VALENCIA MÓNICA , GALLO GARCÍA YULIANA , GUTIÉRREZ SÁNCHEZ PABLO ANDRÉS , Marín Montoya Mauricio Alejandro
Published: March 2022

La papa criolla (Solanum phureja Juz. & Bukasov) es uno de los principales productos agrícolas de la región Andina de Colombia. Su siembra ocurre principalmente en pequeñas parcelas con deficiencias técnicas y bajos rendimientos. Las enfermedades de origen viral son una de las principales limitantes de este cultivo, siendo los virus PYVV, PVS, PLRV y PVV algunos de los más importantes. El nivel de conocimiento que se tiene del viroma de la papa criolla en Colombia es incipiente. En este estudio utilizando técnicas moleculares como secuenciación de alto rendimiento (HTS) y RT-PCR en tiempo real (RT-qPCR), a partir de muestras de tejido foliar de plantas procedentes de diferentes lotes de papa criolla en Antioquia (Colombia), se detectó por primera vez para el país la infección del Potato virus B (PVB), un nepovirus hasta ahora sólo registrado en Perú. Mediante análisis bioinformáticos fue posible el ensamblaje de la mayor parte del genoma de PVB, consistente de dos segmentos de 7.126 nt (ARN1) y 4.298 nt (ARN2) que codifican para dos poliproteínas (P1 y P2). Con las secuencias obtenidas se diseñaron primers específicos para la detección del PVB por RT-qPCR y RT-PCR convencional. Los resultados indicaron niveles medios de prevalencia (35%) del PVB en los cultivos de papa criolla evaluados y su ausencia en las 20 muestras evaluadas de S. tuberosum var. Diacol-Capiro. Con las técnicas aquí empleadas, se sugiere el establecimiento de un programa de seguimiento epidemiológico de PVB en Colombia y otros países andinos.
Consideraciones para la visibilidad estadística de la población trans* en el sistema educativo costarricense
Authors: Jiménez Asenjo Wendy
Published: March 2022

Se considera que la visibilidad estadística de la población trans* es necesaria para el reconocimiento efectivo de los derechos humanos. Por lo tanto, es menester revisar la manera en la que actualmente se construyen las variables e indicadores de género. Lo anterior, con el fin de analizarlas a la luz de algunas discusiones teóricas que deben considerarse para contribuir a una nueva propuesta que dé cuenta de la diversidad de género presente en los centros educativos de Costa Rica. Se concluye que en el sistema educativo aún se utiliza la variable sexo (hombre-mujer) como parte de las formas de clasificación del estudiantado. Por lo anterior, es necesario contar con la definición de nuevas variables e indicadores que contribuyan al diseño de una política educativa dirigida a respetar y reconocer a una población que, históricamente, ha sido excluida del sistema en razón de su identificación de género.
Factors Influencing Depression in Older Adults According to Family Structure (Older Adults Living with Adult Children, a Spouse, or Alone): Data from the 2020 National Older Koreans Data
Authors: Yun Kyoungsun , Lee Yu-Jin
Published: March 2022

Purpose: This descriptive research study aimed to identify the factors that influence depression according to household type (older adults who live with a spouse, adult children, or alone).Methods: A total of 9,790 older adults were selected and analyzed using the 2020 National Older Koreans data. A Rao-Scott x2 test was conducted to evaluate the differences in the individual, health-behavior, and mental-health factors according to family structure. A complex samples logistic regression was used to analyze the factors that influence depression according to family structure.Results: Depression according to family structure was in the order of older adults who live alone, with adult children, or a spouse (p<.001). Total income, number of chronic diseases, hospitalization, exercise, and suicide ideation were identified as depressive factors for older adults who live with adult children. Employment, subjective health status, number of chronic diseases, hospital visitation, hospitalization, drinking, suicide ideation, economic status satisfaction, and cultural life satisfaction were depressive factors for older adults who live with a spouse. Employment, subjective health status, hospitalization, drinking, suicide ideation, and cultural life satisfaction were depressive factors (p<.05) for older adults who live alone.Conclusion: It is necessary to detect depression early and operate a mental health program considering the family structure of older adults.
Person-Centered Care Experience of Nursing Home Workers: A Qualitative Meta-Synthesis Study
Authors: Kim Eun Young , Chang Sung Ok
Published: March 2022

Purpose: To systematically review the qualitative research related to the person-centered care experience of nursing home workers, and synthesize the results to integrate understanding.Methods: Noblit and Hare’s meta-ethnography method was applied. Seven databases were used to search the literature: PubMed, Web of Science, EMBASE, CINAHL, RISS, National Assembly Library, and Korea Citation Index (KCI).Results: Eight qualitative studies were included for the review. Three themes were synthesized: “Comprehensive understanding of nursing home residents”, “Narrowing the psychological distance with residents”, and “Moving towards the provision of tailored care”.Conclusion: Through this study, it was possible to improve the understanding of person-centered care experienced by nursing home workers. The results of this study suggest a direction for the development of person-centered care in elderly care facilities, and provide evidence for further research.
Colony PCR for screening transgenic Ostreococcus tauri v1
Authors: Adhikari Shikha , Losbanes Faith , Karthikaichamy Anbarasu
Published: March 2022

Colony PCR protocol for screening transgenic Ostreococcus tauri
[RETRACTED] Premium Jane CBD Gummies Review 100% Safe Benefits, Side-Effects |Update 2022| v1
Authors: Jane CBD Gummies Premium
Published: March 2022

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[RETRACTED] 7 Secrets IRON MAXXX Male Enhancement Reviews -What are Customers Saying? Know the Truth! v1
Authors: not provided officialironmax
Published: March 2022

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Published: March 2022

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Published: March 2022

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Language of Violence in Social Media: A Linguistic Cognitive Study
Authors: Al-Tamimi Jinan
Published: March 2022

Language is not a fixed structure, but a changeable group whose contents the violence. First, we do not choose our native language. Second, we do not choose the concepts prevailing in our culture. However, we have neither the capacity nor the choice to escape the power of language. This research presumes the existence of the phenomenon of language violence in dialogue with the other, in dialogue with oneself, as well as hidden violence in language. It also presumes that this phenomenon has cognitive dimensions through which violence structures are built into general concepts, which are feared to be physically realized in reality. What arises within the language may be processed within the language before it appears in reality. This study examines the cognitive dimensions of language violence and its recent manifestations of social networking by analyzing selected models of social media by taking advantage of cognitive linguistic data to figure out the cognitive images of language violence used by social media dialogists/interlocutors. In other words, it is an attempt to reveal how words and compositions are used as a weapon by which the speaker attacks the dialogist. This study does not abide by strict time limits but adheres to the study of the phenomenon in models of expressions currently used on social media. On the other hand, it discusses the roots of violence in models of expressions in the Arab heritage in the past. All these contexts are in peace, not war.
On the Awakening of Female Consciousness in It Happened One Night
Authors: Yao Shuo
Published: March 2022

In the 1930s, the United States was at the beginning of the Great Depression, while at the same time its film industry was booming. The screwball comedy as a new type of film became popular. One of the most representative and successful screwball comedies, It Happened One Night by Frank Capra in 1934, which not only won five awards of the Seventh Oscar, but also saved the Columbia Pictures from bankruptcy, can be called a miracle in the history of American film. As a pioneering work of the screwball comedy, the film's theme, narrative and other aspects have exerted profound influences on the subsequent films of this kind. Among the many advantages of this film, it is worth noting that the image of the heroine breaks people's traditional idea about women, which is ahead of its time. Besides, we can see her gradual awakening of female consciousness. Therefore, combining with the social and historical background at that time and the characteristics of the screwball comedy, this paper attempts to reveal the female image of the heroine Ellie and give a general view of the course of her consciousness awakening by analyzing lens language of the film, including shots, lighting and sound, together with the narrative.
The Application of Translation Procedures in Translating Five Public Signs in Ubud
Authors: Ariani Ni Made , Artawa Ketut
Published: March 2022

This study analyzes five public signs in English found in the area of Ubud, Bali, Indonesia. The purposes of this research are to identify the grammatical errors in the process of translating the information conveyed on these five public signs and to understand the translation procedures applied in the translation process. The first finding of this study is that grammatical errors are found on the first, second and fifth public signs. Meanwhile, the second finding of this study is four translation procedures are applied, which are Modulation, Transposition, Literal Translation and Calque. Another interesting finding, which can be found in this research, is the fact that the application of these translation procedures plays a very crucial role in determining the quality of the translation product as well as in contributing the occurrence of the grammatical errors.
Factors Affecting EMI Attitudes of Engineering and Nursing Students
Authors: Wilang Jeffrey Dawala , Nupong Supasinee
Published: March 2022

The internationalization of higher education has led to the increasing number of English as a Medium of Instruction (EMI) programs in contexts where English is not the first language nor the medium of communication, including Thailand. The introduction of EMI programs, however, is not without challenges. Therefore, a survey questionnaire was used to investigate the attitudes of engineering and nursing students toward EMI. Differences of attitudes based on the program of study, gender, nationality, year level, number of years studying English, the language of instruction in high school, Common European Framework of Reference for Languages (CEFR) level, and perceived proficiencies in speaking, reading, writing, and listening were explored. In addition, factors affecting the students’ EMI attitudes were known using exploratory factor analysis. Findings have shown significant differences in various aspects of EMI based on the program of study, CEFR level, and perceived proficiencies of the four macro language skills. Also, eight factors were elicited, including difficulties of the English language, availability of resources and opportunities, personal goals in life, limitations of time when studying content courses in English, providing activities to improve English language proficiency, enhancement of career goals, supports needed, and motivation and intercultural ability. Finally, implications were outlined to support the implementation of EMI, dubbed as an “unstoppable train”, in similar contexts like Thailand.
Addition With Reference to the Arabic Translation of “The Sniper”
Authors: Albainy Ramez , Jabak Omar
Published: March 2022

The present study aimed to highlight addition as a translation strategy adopted by literary translators. It also aimed to examine addition with reference to an Arabic translation of the short story “The Sniper” written by O’Flaherty (1923). The researchers adopted the translation-by-addition strategy proposed by Dickins et al (2017) as the theoretical framework for their study. They also conducted a contrastive analysis and developed a taxonomy of types of addition which were identified as per the analysis. The findings revealed that the Arabic translation exhibited numerous examples of addition some of which did not change the meaning, some slightly changed the meaning and others changed the meaning. Based on the findings, the researchers recommend that further research be done on addition as a translation strategy followed by literary and non-literary translators to confirm or challenge the findings of this study.
English Education and Large Classes: Unpacking the Challenges and Coping Strategies
Authors: Erlina Dian , Marzulina Lenny , Harto Kasinyo , Holandyah Muhammad , Wulandari Bunga Ayu , Fauzan Muhammad , Fridiyanto Fridiyanto , Mukminin Amirul
Published: March 2022

The purposes of our study were to explore the perceptions of English teachers’ on the challenges and the strategies in teaching large classes. Our participants were English teachers. We investigated the case in two large classes through a qualitative case study. We employed observations and interviews to collect the data. To analyze the qualitative data from observations and interviews, the thematic analysis was used. We analyzed the data first by putting all the data into computer files and the filed folders after transcribing the raw data into texts. Then, we began making codes for all of data and themes that are related to our research questions. The last, we presented the table of themes and codes into the findings and results. Based on the data analysis, we found seven important challenges encountered by our participants in teaching large classes including poor class conditions, difficulties or problems in controlling/monitoring the discipline of their students, the equality of attention to students, difficulties or problems in evaluating their students, ineffectiveness or uselessness of learning processes, deficient interest in learning English, the dominant use of local languages. In terms of strategies, we found six important strategies employed by our participants in dealing with the challenges including punishment, variety of games, quiz, pair work or group work, supporting media, and speaking test. In conclusion, our participants faced teaching challenges while they also found some approaches or methods to deal with the problems.
Pupils’ and Parents’ Perspectives Towards Using Smartphone Strategies to Improve Reading Skills
Authors: Sulaiman Suher , Mohamad Maslawati , Mansor Azlin Norhaini , Alias Bity Salwana , Aziz Azlina Abdul
Published: March 2022

In this 21st century, reading skill is one of the most essential skills to achieve language literacy. On this basis, an early introduction to proper reading strategies shall develop good attitudes towards reading. Based on a study conducted by the Malaysia National Library in 2015, the rate of reading is lower among Malaysians, with only 15 to 20 books on average per year. Due to this, the researchers conducted a reading workshop, “Using Smartphone to Improve English Skills” in three districts in three different states. This qualitative study was embarked to explore the perception of workshop participants (pupils and parents) towards the reading workshop. Despite the pupils’ and parents’ perceptions towards the workshop which generally are positive, however, some suggestions are given to further improve the reading workshop. The participants in this study consisted of 79 people of different ages, races and socioeconomic statuses. The pupils are from primary schools with the ages of 10 to 12 years old (Year 4 to Year 6) and the parents are from the ages of 25 to 50 years old. They are residents of the Southern region of Malaysia which are Negeri Sembilan, Melaka and Johor. The research instruments employed were field notes, open-ended interview responses from Google Form and semi-structured interview responses. The findings suggested that the majority of the students and parents agreed that the various reading strategies introduced using smartphones are both interesting and exciting and may serve as the focus of future studies. The study implies that the smartphone reading strategy workshops should be carried out at different locations to enhance the pupils’ reading skills in reading English materials. Both parents and their children should participate in this workshop to ensure the strategies could be practiced effectively at home.
Increasing Reading Speed and Comprehension of EFL Undergraduate Students at a Saudi Arabian University Using Speed Increasing Software
Authors: Abdul-Rab Salahud D. , Alward Mohammed A. , Abdul-Hamid Samsiah
Published: March 2022

Students’ reading speed in the English Department at a Saudi University is low, which, in turn, slows down their general proficiency in English. This research aims to show how and to what degree using a reading speed increasing software (the ‘7 Speed Reading’ program) could be a decisive factor in upgrading the reading speed of EFL-major students of KKU while maintaining their former level of comprehension. This study uses a pre-test, post-test quasi-experimental design. The study sample comprised two groups (a control group and a test group), each consisting of 30 students from the third year of the EFL undergraduate program. The methodology incorporates comprehension tests to analyse the sample for reading speed and comprehension toward the study’s start. Training in increasing reading speed was extended to the test group students using the ‘7 Speed Reading’ software. Towards the end of the training, both the groups were tested again for reading speed and comprehension. The study illustrated essential outcomes in the form of increased reading speed and better comprehension.
A Comparable Corpus-Based Study of Cross-Strait Varieties: The Case of 注意 Zhùyì and 專心 Zhuānxīn
Authors: Liu Jiexiu , Chen Yingying
Published: March 2022

Chinese Word Sketch (CWS) provides a tool to identify the semantic distinctions of the Chinese near synonyms in the natural language use situation. This study has the case of 注 意 Zhùyì and 專 心 Zhuānxīn, with Gigaword_CNA and Gigaword_XIN, two of the main sub-corpora in CWS, as the corpora for the research. Based on the comparison of senses and part of speech (POS) from Chinese Word Net and dictionaries, it is found that there are some disagreements of the POS between the ones prescribed by dictionary and in actual language use. What is more, some similarities and differences have been revealed based on the common and only patterns in the two sub-corpora. The study aims to reveal the variations of the two keywords in Taiwan Mandarin and Mainland Mandarin, which will contribute to the revision of the dictionary and facilitate a better understanding of cross-strait communication.
Resistance Through Language Appropriation to Create a Reality for Oneself in the Postcolonial Nigeria
Authors: Brown Magdelene H. , S. Patchainayagi
Published: March 2022

the paper explores the reasons behind appropriating the English Language to carry the native's experiences and the strategies deployed by the authors of Nigeria to reconstruct Africa's taunted imageries and cultures through their use of language. This article also examines the pattern that has been documented in Nigeria and re-evaluates some of the identified resistant strains that authors consciously or unconsciously integrate to ensure that their works are authentic. Author/Character/community or a nation is built through an indigenous choice of vocabularies that reflect the meanings of native society. Creative authors, especially with the postcolonial attitude, employ narrative strategies by using indigenous phrases and other signifiers to deviate from the standard variety to foreground the indigenized realities of the marginalized. Appropriations in the English Language help the colonized reconstruct their culture and history's lost and hidden truths. These strategies give the text an authentic identity representing the bare realities of the indigenous community. The indigenized medium of expression is also considered a form of resistance towards Eurocentric linguistic hegemony. The colonized writers articulate their native ideologies and beliefs without depending on the medium of a foreigner. The collection of criticisms in this paper will enable the upcoming writers to know and discover the elegance and inestimable elements in their native Nigerian literature than foreign literature with an alien culture that is hardly incomprehensive. The work also confirms the mimetic nature of Language and its interdependence with society.
The Role of Cultural Reservation Center (BPCB) Jambi In Preserving History Site: Situs Bukit Siguntang
Authors: Andi Andi , Gunawan Rudy , Utami Nadia , Rizki Ainul , Azzahra Hana Fatimah
Published: March 2022

Palembang is the oldest city in Indonesia, a historic city, and a city that is respected with the greatness of the glory of the Srivijaya kingdom. Various events have become important historical traces for the local and general public, one of the historical traces is historical sites. The many historic sites in Indonesia make the central government make laws about cultural heritage that must be preserved. One of the famous sites in Palembang is the Siguntang Hill Site. The management of the Bukit Siguntang Site is entered into the regional government and overseen by the BPCB. The purpose of this study was to determine the role of the BPCB Jambi on the Bukit Siguntang Site and the local government that included the community in the preservation of the Siguntang Hill Site. Data collected through a qualitative approach by exploring and interviewing participants accompanied by a review of various literature. The results of this study are that Jambi BPCB has a sufficient role especially in zoning the Bukit Siguntang Site area which is divided into three zones, namely: the core zone, the buffer zone, and the development zone. The regional government develops and utilizes the Siguntang Hill Site by building various supporting facilities to become historical attractions. The conclusion is that the BPCB Jambi has a role in preserving the Bukit Siguntang Site through supervision and monitoring as well as activities that involve collaboration with the local regional government.
Peranan Penting Sejarah Lokal sebagai Objek Pembelajaran untuk Membangun Kesadaran Sejarah Siswa
Authors: Syahputra Muhammad Afrillyan Dwi , Sariyatun Sariyatun , Ardianto Deny Tri
Published: March 2022

Kajian ini bertujuan untuk menganalisis peranan penting sejarah lokal sebagai objek pembelajaran sejarah untuk membangun kesadaran sejarah yang rumusan masalahnya meliputi : (1) Bagaimana sejarah lokal dapat menjadi objek pembelajaran sejarah? (2) Bagaimana sejarah lokal dapat membentuk kesadaran sejarah? Untuk menjawab permasalahan di atas, penulis menggunakan metode studi literatur dengan mengumpulkan beberapa artikel dari hasil penelitian yang sesuai dengan tema kajian penelitian serta sumber-sumber tertulis lainnya. Hasil penelitian menunjukkan bahwa sejarah lokal sangat beperan penting sebagai pembentuk kesadaran sejarah terutama  di era  digital. Sejarah lokal disuatu daerah dapat diimplementasikan pada pembelajaran sejarah di sekolah maupun di perguruan tinggi. Pemanfaatan sejarah lokal ini di anggap efektif membentuk kesadaran sejarah peserta didik dan bahkan masyarakat karena sejarah lokal merupakan media atau sarana sebagai pembentuk identitas bangsa melalui kesadaran sejarah, serta sebagai acuan tepat bagi tenaga pendidik untuk memperkenalkan peserta didik tentang sejarah lokal yang ada di lingkungan sekitar mereka dengan menyajikan peninggalan-peninggalan sejarah sebagai wujud budaya. Dengan memanfaatkan peninggalan sejarah disekitar kita dapat lebih menumbuhkan kesadaran sejarah yang berujung kepada timbulnya rasa cinta tanah air serta mengokohkan identitas Indonesia sebagai bangsa yang besar dan bangsa yang tidak akan pernah melupakan sejarahnya.
The Effect of Using Digital Concept Cartoons in Science Lesson on Students’ Achievement
Authors: Şanlıtürk Arda Danıştay , Zeybek Gülçin
Published: March 2022

In the digital age we live in, electronic teaching materials can effectively increase students' participation in the learning and teaching process. In addition, it is known that using visual materials in science education has a positive effect on learning in this direction. The study aims to determine the effect of digital concept cartoons in the sixth-grade science course on the academic achievement of students and the retention of what is learned in the lesson and to determine the students' views on the concept cartoons applied in the lesson. This research was carried out with sequential mixed design, one of the mixed designs in which quantitative and qualitative research methods are used. The quantitative dimension of the study was conducted with a random experimental design with the pretest-posttest control group, and the qualitative dimension was carried out with a case study design to support the quantitative data and make an in-depth analysis of the data. A significant difference in favor of the experimental group was found between the post-test and retention test mean scores of the experimental and control group students participating in the study. Based on these findings, it can be said that the use of digital concept cartoons in the sixth-grade science course "reproduction, growth, and development in plants and animals" unit is effective in ensuring academic achievement and the retention of what is learned in the lesson. This finding of the study is parallel with qualitative findings
Comparing Effects of Two Different Explicit–Reflective Instructions on Pre-School Prospective Teachers’ View about Nature of Science and Scientific Knowledge
Authors: Metin Mustafa
Published: March 2022

This study aims to compare the effect of formative assessment with explicit-reflective instruction and explicit-reflective on pre-school prospective teachers' views about the nature of science and scientific knowledge. In this study, it was used a pretest-posttest nonequivalent control group design and the sample of the study consists of 66 pre-school prospective teachers in the 2nd grade. There are 33 of them were assigned control group and the others were assigned as the experimental group. Since the students could not be randomly grouped in the study, a quasi-experimental design was used. In this study, the nature of science scale (NOSS) and the attitude scale towards scientific knowledge (SKS) were used as pre-test, post-test and retention test.  In order to teach the students by using nature of science (NOS) and scientific knowledge (SK), open-reflective instruction was used in the control group, and open-reflective instruction and embedded formative assessment were applied in the experimental group. NOSS and SKS were used as a pre-test, post-test and retention-test in this study. In order to teach the students NOSS and SK, while Explicit-reflective instruction was applied in the control group, formative assessment embedded with Explicit-reflective instruction was applied experimental group.As a result of the study, it was determined that the formative assessment embedded with Explicit-reflective instruction was more positively and permanently changed on pre-school prospective teachers' view about NOS and SK than the other method
The scientific and technological revolution and the formation of ecological thinking among doctors
Authors: Chikin S. Ya.
Published: March 2022

The scientific and technological revolution and social progress have led to the development of productive forces in many countries, including our own, but at the same time have had consequences that have had a deleterious effect on nature and all living things.

According to WHO, improving the environment is a task that is beyond the capacity and power of health authorities. Such a conclusion is quite logical. Many bodies should be involved in this problem, and the goal is that they should effectively make a difference in improving human health while using the resources at their disposal.
Causes of occupational injuries in the dairy industry
Authors: Nushtaev I. A.
Published: March 2022

All the causes of occupational traumatism can be grouped into three groups: technical, sanitary-hygienic and organizational-personal (subjective).The study of occupational traumatism at the dairy industry enterprises of the Saratov region in 1967-1976 and in 1977-1986 showed that during the first observation period the organizational-personal (subjective) causes amounted to 48.1%, sanitary-hygienic causes to 17.4%, technical causes to 19.6%, and other causes to 14.9%. In the second observation period, the ratio of causes was different: technical causes accounted for 9.4%, sanitary and hygienic causes for 23.8%, and subjective causes for 66.8%.
Analysis of the effectiveness of counter-cycling treatment of peptic ulcer patients with blood products and traditional methods
Authors: Pirozhnik L. A. , Sinitsyna G. M. , Testoyedova T. A.
Published: March 2022

The problem of gastric and duodenal ulcer treatment, in spite of many proposed methods and means, remains far from being solved until now. In the modern concept of ulcerogenesis some researchers in the development of peptic ulcer disease attach great importance to biogenic amines, in particular to histamine, which, affecting the lining cells, stimulates the secretion of gastric juice of high acidity, changes capillary blood circulation and acts on trophic processes in the mucosa of gastroduodenal zone. It has been found that in patients with peptic ulcer disease the content of histamine in the blood is increased, especially during exacerbation of the disease; at the same time in patients the processes of binding and inactivation of histamine are disrupted.
Dependence of clinical manifestations of neuroendocrine syndromes and treatment results on the severity of endocraniosis
Authors: Mikhailov M. K. , Mindubaeva F. Z.
Published: March 2022

The high frequency of neuroendocrine disorders in gynecology requires elucidation of their pathogenetic mechanisms in order to develop effective methods of treatment and further rehabilitation of patients. In women with neuroendocrine disorders, endocraniosis in various manifestations is often revealed. The radiological picture of endocraniosis is quite diverse and includes different types of hyperostoses of the bones of the cranial roof and skull base, calcifications of the dura mater and certain brain areas. The most pronounced manifestation of endocraniosis is hyperostosis of the inner lamina of the cranial vault bones - frontal, parietal, and occipital.
Psychopathological features of acute intoxication with xenobiotics with central cholinolytic action in patients with substance abuse
Authors: Vagin N. A. , Sarkisov S. A. , Chudin A. S. , Grushin V. V.
Published: March 2022

Clinical symptomatology of acute poisoning by drugs with central cholinolytic action is little known to practitioners. Drug dependence due to systematic intake of drugs is accompanied by tolerance to them and loss of control over intake, the consequence of which is often acute poisoning.
Orthostatic iliopsoas-lumbar spasm in torsional dystonia and parkinsonism
Authors: Esin R. G. , Ivanichev G. A. , Popelyansky Ya. Yu.
Published: March 2022

In the study of the pathogenesis of muscular dystonic syndromes, it is very important to identify the role of central and peripheral factors and their correlation in the formation of the disease pattern. It is known that the peripheral focus often plays a significant role in the inversion of pathological mechanisms in conditions of decreased activity of the central ones. The correlation of these factors can be illustrated by the recently described clinical picture of iliopsoas lumbar spasm, which is not so rare in the practice of a neurologist.
Principles of intensive therapy for rhinogenic orbital and intracranial complications
Authors: Svatko L. G. , Petushkov E. V.
Published: March 2022

Patients with rhinogenic orbital and intracranial complications require urgent care and treatment involving various specialists. On the basis of the clinical material for 35 years including 347 orbital and 33 intracranial complications the modern rational tactics of their emergency therapy at inflammatory diseases of the paranasal sinuses was developed. Treatment of patients with orbital and intracranial rhinogenic complications requires timely wide scale surgical intervention and vigorous medication therapy. Urgent surgical intervention on all affected paranasal sinuses with revision of the orbit or cranial cavity is mandatory. X-ray examination of the paranasal sinuses, puncture of the maxillary sinuses and trepanopuncture of the frontal sinuses, EEG, ECHO-EG, REG data help in determining the volume of surgical intervention. As a rule, it is necessary to open all affected sinuses on one side or even switch to the other side. In rare cases, it is necessary to open all perinasal sinuses on both sides. When performing a radical operation of the frontal sinus, it is necessary to perform mandatory revision of the other sinus through the intercorporal septum.
Bacterial endotoxins and diseases of the digestive system
Authors: Shenkman B. Z. , Gracheva N. V.
Published: March 2022

For many years, researchers have been interested in the question: do bacterial endotoxins penetrate the intestinal barrier intact? Despite the abundance of factual data obtained in clinical and experimental studies, this question still remains open.
Application of the acetylcholine test to study the effect of air pollution on respiratory function
Authors: Sabirova Z. F.
Published: March 2022

In the literature there are no data on the use of acetylcholine test to study changes caused by the effects of air pollution in the respiratory system of healthy children. Given the significantly higher level of respiratory system diseases, including allergic etiology, among children living in areas with a high degree of air pollution, these studies seem to be very relevant.
Hypertrophic cardiomyopathy
Authors: Galyavich A. S. , Oslopov V. N. , Khasanov Z. Sh. , Nefyodova A. I. , Zagainova E. N.
Published: March 2022

Hypertrophic cardiomyopathy is due to a so-called primary myocardial lesion. In typical cases, the interventricular septum is hypertrophied to a greater extent than the free wall of the left ventricle. Another variation of this disease is uniform concentric myocardial hypertrophy with a significant increase in heart mass. Although the etiology of hypertrophic cardiomyopathy is unknown, it is thought to be genetically determined by autosomal dominant transmission with a high degree of penetrance. The burdened heredity and familial nature of the disease occur in almost 60% of these patients, so the examination of their close relatives is of particular interest.
Results of treatment of female genital diseases in the balneo-physiotherapeutic association of the complex of sanatoriums-preventoriums
Authors: Gimadiyeva S. R.
Published: March 2022

The organization of the balneo-physiotherapy association (BFO) of the complex of sanatoriums-preventoriums of Kuibyshev Regional Council of Trade Unions made it possible to concentrate the efforts of doctors and nurses transferred from sanatoriums-preventoriums and to organize a powerful therapeutic base. BFO works in two shifts from 8 to 21 hours, serves 14-15 visits each sanatorium-preventorium. Treatment is provided with and without a break from work. The complex of sanatoriums annually treats 23-24 thousand people.
Long-term results of treatment of polymorphic salivary gland adenomas
Authors: Lepilin A. V. , Shashkov P. F. , Zavrazhnova A. I. , Serova T. A.
Published: March 2022

We analyzed the clinical course of polymorphic salivary gland adenomas, distant results of their treatment, morphological features of the course of tumors and their recurrences.
Clinical thinking style in screening research settings
Authors: Tetenev F. F.
Published: March 2022

When performing diagnostic actions in everyday life, the doctor does not think about why he does it so and not otherwise. The researcher is forced to think about his thinking style when the need arises to change it due to the objective processes of clinical diagnostic development. Among these we can mention the following: 1) intensification of examination (diagnosis is becoming more morphological); 2) increasing role of the functional component of clinical diagnosis, which plays a crucial role in the diagnosis of pre-disease and so-called borderline conditions; 3) formation of a new type of medical examination - screening; 4) use of the computer in diagnostics.
On the use of coenzyme therapeutic complex in patients with idiopathic Abramov-Fiedler myocarditis
Authors: Mazurec A. F.
Published: March 2022

Insufficient effectiveness of cardiotonic therapy in patients with Abramov-Fiedler myocarditis is largely due to profound metabolic changes in the affected heart muscle. These disturbances concern primarily the mechanisms of enzyme regulation of myocardial protein-synthetic and energy metabolism. The action of a number of coenzyme preparations synthesized in recent years is aimed at correction of these metabolic shifts. As a metabolic therapy we chose pyridoxalphosphate, a multifunctional biological agent that participates as a prosthetic group of transaminases, decarboxylases and other enzymes in reactions of synthesis of amino acids, purine and pyrimidine bases.
Experience of using the "Lenta MT" cardiocomplex
Authors: Galyavich A. S. , Nefyodova A. I. , Saitova R. A. , Akhmetova F. M.
Published: March 2022

The aim of this work was to study the experience of using the domestic cardiac complex "Tape MT" to record ECG during 16 hours on a magnetic tape in a cardiology dispensary. Since June 1987, 161 ECG recordings on magnetic tape were performed for different diseases of cardiovascular system.
Changes in serum immunoglobulin content during correction of congenital heart disease under conditions of artificial circulation
Authors: Medvedev V. N. , Kharitonov G. I. , Valeev R. A.
Published: March 2022

In patients with congenital heart disease, the dynamics of immunoglobulins during AIC surgeries are not reflected in the available literature. The study of these indices seems important, since the data concerning patients with acquired heart defects cannot be fully extended to patients with congenital pathology. This is due, firstly, to the fact that in acquired malformations patients' immunological reactivity is significantly altered by rheumatic process and chroniosepsis and, secondly, to the fact that the duration of artificial circulation in valve replacement is significantly longer than in the correction of congenital heart disease.
Viral immunodeficiencies. Mechanisms of postinfectious immunopathology
Authors: Pozdeev O. K. , Rakhmatullin I. M.
Published: March 2022

It is known that the development of viral infections is often accompanied by nonspecific modulation of the immune response to various antigens. The genera of viruses with immunomodulatory properties are rather broad: more than 40 species belonging to 15 different families cause changes in humoral and cellular responses [5]. The formation of an immune response to viral antigens is subject to all the rules of immunological response. Its main focus is related to the suppression of virus multiplication rather than its rapid elimination.
Training aids to optimize the educational process in perinatology
Authors: Benediktov I. I.
Published: March 2022

A group of scientists from the Kurashov Kazan Order of the Red Banner of Labor Medical Institute and the Kursk and Voronezh Medical Institutes over 12 years have developed a number of textbooks for obstetrician-gynecologists, pediatricians, subordinate students and interns, which soon after their publication found a very favorable response among readers. The textbooks are devoted to current problems of perinatology and are recognized to play a role in reducing perinatal morbidity and mortality.
Letter to the Editor. Vol. 70, No. 5 (1989)
Authors: Vakhitov Sh. M.
Published: March 2022

Dear Editor!In the process of implementing the program of diabetes mellitus prevention in TASSR, it became necessary to analyze the possible links between this disease and a number of indicators characterizing the activity of medical and preventive institutions (MPI), the provision of the population with health care resources and the intensity of their use.