bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential regulatory mechanism of TNF-α/TNFR1/ANXA1 in glioma cells and its role in glioma cell proliferation
Authors: Zhu Xiaotian , Shi Guanhui , Lu Jinbiao , Qian Xin , Wang Donglin
Published: March 2022

The purpose of this study was to explore the regulatory mechanism of Annexin A1 (ANXA1) in glioma cells in the inflammatory microenvironment induced by tumour necrosis factor α (TNF-α) and its effects on glioma cell proliferation. CCK-8 analysis demonstrated that TNF-α stimulation promotes rapid growth in glioma cells. Changes in tumour necrosis factor receptor 1 (TNFR1) and ANXA1 expression in glioma cells stimulated with TNF-α were revealed through western blot analysis and immunofluorescence staining. Coimmunoprecipitation analysis revealed that ANXA1 interacts with TNFR1. Moreover, we found that ANXA1 promotes glioma cell growth by activating the p65 and Akt signalling pathways. Finally, immunohistochemistry analysis showed an obvious correlation between ANXA1 expression and Ki-67 in glioma tissues. In summary, our results indicate that the TNF-α/TNFR1/ANXA1 axis regulates the proliferation of glioma cells and that ANXA1 plays a regulatory role in the inflammatory microenvironment.
Statistical analysis on the radiological assessment and geochemical studies of granite rocks in the north of Um Taghir area, Eastern Desert, Egypt
Authors: Awad Hamdy A. , Abu El-Leil Ibrahim , Nastavkin Aleksey V. , Tolba Abdellah , Kamel Mostafa , El-Wardany Refaey M. , Rabie Abdalla , Ene Antoaneta , Tekin Huseyin O. , Issa Shams A. M. , Zakaly Hesham M. H.
Published: March 2022

Granite rocks are currently one of the foremost raw materials that can be used for various economic purposes such as ornamentation and building materials, because they do not possess radioactive concentrations and have good physical and mechanical properties. The granite rocks of north Um Taghir are connected to neoproterozoic rocks and integrated to the north Arabian-Nubian Shield (ANS), which lies in Northeast Africa. Inductively coupled plasma mass spectrometry (ICP-MS) and X-ray fluorescence analysis, concurrent to some statistical analysis, have been carried for major oxides and some trace elements to extract much fundamental information by following certain mathematical methods. The exposed granite rock units in north Um Taghir are classified into four rock units represented by tonalite, granodiorite, monzogranite, and alkali-feldspar granite which are cut by different types of dikes. The magma of tonalite and granodiorite is low-to-medium K calc-alkaline affinity, while the magma of monzogranite and alkali-feldspar granite is medium-to-high K calc-alkaline affinity, and of metaluminous to peraluminous nature. Granite rocks show a slightly depletion of fractionated patterns from light rare earth elements (LREEs) to heavy rare earth elements (HREEs) with slightly positive to negative Eu anomalies from tonalite to monzogranite and alkali-feldspar granites. The statistical criteria have been achieved to explore the significant differences of radiological hazard parameters among samples. It is obvious that there is no homogeneity among samples; furthermore, in Kruskal–Wallis test, Mann–Whitney test, and Pearson correlation coefficient, it can be noticed that there are significant differences between each pair of samples: tonalite, monzogranite; tonalite, alkali-feldspar granite; granodiorite, monzogranite; and granodiorite, alkali-feldspar granite. There is a strong direct relationship among granodiorite and both tonalite and alkali-feldspar granite, and among alkali-feldspar granite and tonalite and granodiorite. There is a strong inverse relationship among monzogranite and tonalite, granodiorite, and alkali-feldspar granite. As stated by all results, it can be mentioned that the granite rocks have a worthy result of mechanical and physical properties. So that they can be used for various economic purposes.
The investigation of ferro resonance voltage fluctuation considering load types and damping factors
Authors: Shemshadi Asaad , Khorampour Pourya
Published: March 2022

Background and Objectives: The occurrence of ferro resonance is a very complex phenomenon in power systems. In circuits including inductors and capacitors, if the value of zc = zl becomes, an intensification or resonance state is created in the circuit. In circuits and networks that have saturated inductors, nonlinear resonance or ferro resonance is created, Ferro resonance is a nonlinear resonance phenomenon that occurs between the network capacitor and the nonlinear inductance of the transformer during saturation. Ferro resonance at the main frequency and higher frequencies cause insulation problems and at low frequencies causes thermal problems. In the event of this phenomenon, the voltage range increases to a considerable extent and may also be distorted, which due to the structure of the winding connections in transformers can cause damage to electrical installations. Methods: In this paper, we study and simulate the phenomenon of ferro resonance and provide solutions such as using high resistance on the primary side of the transformer and the combination of resistors and inductors on the secondary side of the transformer to damp the ferro resonance in MATLAB software. Furthermore, the utilization of surge arresters is discussed in detail. Results: It is illuminated that utilization of suggested approaches has an acceptable reduction rate on the damping of ferro resonance fluctuations. Especially when using resistor and inductor simultaneously the fluctuations reduce and ferro resonance is damped immediately. Conclusion: It is important to pay attention to the transformer and the amount of capacitors in transmission lines, especially cable lines. Furthermore, asymmetric switching is another important factor. High resistance can reduce fluctuations but causes power losses in the circuit but using Resistance and inductor structure are able to create acceptable damping and reduce fluctuations without loss problems. The presence of a surge arrester can also reduce the overvoltage caused by ferro resonance to an appropriate level.
Engagementpolitik und Demokratiepolitik
Authors: Klein Ansgar
Published: March 2022

Mit dem Begriffsverständnis des „bürgerschaftlichen Engagements“ eng verbunden ist ein normatives Verständnis, in dem die politischen Gestaltungsansprüche als wesentlicher Bestandteil eines immer eigensinnigen und freiwilligen Engagements gelten. Engagement und Partizipation haben in diesem neueren Verständnis einen engen und nicht auflösbaren Zusammenhang, weil die Gestaltung der Gesellschaft im Kleinen durch Engagement die Bezüge zu den darauf gerichteten politischen Entscheidungen und zugleich Beteiligungsansprüche schafft. Daher hat Engagementpolitik immer auch enge Bezüge zur Demokratiepolitik. In der Folge der Enquete-Kommission haben sich über die Aktivitäten von Bund, Ländern und Kommunen die neuen und fragilen Politikfelder der „Engagementpolitik“ wie auch – damit eng verbunden – der „Demokratiepolitik“ entwickelt. Auf Empfehlung der Kommission wurde 2002 das Bundesnetzwerk Bürgerschaftliches Engagement (BBE) gegründet, um zu Fragen von Engagement und Zivilgesellschaft die Interessen und Problemperspektiven aus Zivilgesellschaft, Staat und Wirtschaft zu verschränken und gemeinsam fortzuentwickeln. Der Beitrag gibt einen Überblick über diese Entwicklungen.
Koalition des Aufbruchs in eine moderne Zivilgesellschaft
Authors: Fester Emilia
Published: March 2022

Emilia Fester reflektiert in ihrer Rolle als jüngste Abgeordnete des Bundestags Themen rund um Engagement und Ehrenamt. Dabei geht sie auf konkrete Meilensteine ein, die durch den Koalitionsvertrag erreicht werden konnten und setzt diese in den übergeordneten politischen Kontext. Wertschätzung von Ehrenamt, Anerkennung von Freiwilligendiensten und Respekt für eine freie Zivilgesellschaft müssen aus Sicht der GRÜNEN vielerorts neu positioniert werden. Solch angestrebte Paradigmenwechsel sollten dabei nicht zuletzt in Förderpolitiken und Haushaltserwägungen sichtbar werden, so Fester.
Demokratiepolitik – Erfolge und Herausforderungen in Deutschland
Authors: Roth Roland
Published: March 2022

Zu den demokratiepolitischen Erträgen der letzten Dekade gehört eine beachtliche Ausweitung des Handlungsrepertoires. Dies gilt vor allem für dialogische und deliberative Beteiligungsformate, aber auch für neue direktdemokratische Formen wie Bürgerfonds und Budgets. Neue Leitbilder wie „vielfältige Demokratie“ oder „Bürgerkommune“ sind entstanden und werden praktisch erprobt. Damit sind Umrisse progressiver Antworten auf Erosionen des klassischen Gefüges repräsentativer Politik und autoritäre Rückbildungen sichtbar geworden.

Eine offene Frage ist, wie eine Ausbreitung dieser demokratischen Experimente gelingen kann. Die Devise „mehr Fortschritt wagen“, mit der die neue Bundesregierung angetreten ist, hat bislang kein zureichendes demokratiepolitisches Fundament. Nur wenn die demokratiepolitischen Innovationen des letzten Jahrzehnts auch breit genutzt werden, kann sie erfolgreich sein.
Use of Circular Dichroism in the characterization of the fusion protein SARS-CoV-2 S protein (RBD)-hFc
Authors: Ruíz Ingrid , Gómez Jose A. , García Laura
Published: March 2022

From the receptor-binding domain (RBD) of the SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19), a RBD-hFc fusion protein was obtained at the Center of Molecular Immunology (Havana, Cuba). This fusion protein was used in the construction of a diagnostic device for COVID-19 called Ultramicroenzyme-Linked Immunosorbent Assay (UMELISA)-SARS-CoV-2-IgG and it is currently been used in the studies of biological activity of the Cuban vaccine Abdala (CIGB-66). In this work, Circular Dichroism (CD) is used to characterize this protein. Using Far Ultraviolet Circular Dichroism (FAR-UV CD), it was determined that the protein has a secondary structure in the form of a sheet-β fundamentally. Using this technique, a thermodynamic study was carried out and it was determined that the melting temperature (Tm) of the protein is 71.5 °C. Information about the tertiary structure of the protein was obtained using Near Ultraviolet Circular Dichroism (NEAR-UV CD) and Molecular Fluorescence; they indicates that the protein has a three-dimensional folding associated with the aromatic amino acids in its structure, where tryptophan (Trp) is located inside the folded structure of the protein while tyrosine (Tyr) is exposed to the solvent.
Facilitation of processingdarenimo‘any/everyone’ negative Japanese sentences using prosodic entrainment
Authors: Tamaoka Katsuo , Ji Yuanyuan
Published: March 2022

The present study examined how prosody affects Japanese speakers’ processing of the polarity itemdarenimo‘any/everyone’. Upward (LHHH pitch) and downward (HLLL pitch) prosody fordarenimoassociates with negative and positive polarity, respectively. In Study 1, a corpus search showed thatdarenimois more often associated with negative than positive polarity. In Study 2, subjective acceptability judgments indicated thatdarenimois also more likely to be perceived as acceptable by native Japanese speakers when used with negative polarity. In line with Study 2, Study 3 showed that upward prosody with negative polarity was more accurately and quickly processed than was downward prosody with either positive or negative polarity. These three studies showed a one-sided distribution of upward prosody with negative polarity, and further indicated that only upward prosody facilitates listeners’ processing of negation. Early heightened pitch ofdarenimoprovides a cue to predict an ending negation -naiin the head-final Japanese language, resulting in faster speed and higher accuracy for the processing of negative sentences (i.e., a facilitation effect) compared to their corresponding affirmative sentences.
Synthesis and characterization of nano-SiO2@octadecylbisimidazoline quaternary ammonium salt used as acidizing corrosion inhibitor
Authors: Liu Yunfeng , Chen Lili , Tang Yongfan , Zhang Xingde , Qiu Zhengsong
Published: March 2022

Aiming at the current situation that the existing acidizing corrosion inhibitors are difficult to apply in high temperature, high concentration acid, and other complex conditions, this article uses nano-SiO2as the core and preferably functional monomers to synthesize nano-SiO2@octadecylbisimidazoline quaternary ammonium salt (nano-SiO2@OBQA). Analytical methods such as nuclear magnetic resonance, infrared, and scanning electron microscopy were used for characterization. The corrosion inhibition performance of the N80 steel sheet by nano-SiO2@OBQA in 20% concentrated hydrochloric acid was studied using the high-temperature corrosion testing machine and adsorption isotherm model combined with quantum chemistry calculations to explore its mechanism of action. The results show that nano-SiO2@OBQA has good high-temperature resistance. When the temperature is 180℃ and the dosage of nano-SiO2@OBQA is 4%, the corrosion inhibition rate is 61.42 g·m−2·h−1. Studies have shown that the adsorption of nano-SiO2@OBQA on the surface of the N80 steel sheet follows the Langmuir isotherm adsorption model, which is spontaneous chemical adsorption.
A recursive prefix in Neasu
Authors: Gerner Matthias
Published: March 2022

Neasu (Tibeto-Burman: China) exhibits a prefix that derives new coordinators from existing ones by elaborately changing their subcategorial properties. Prefixed and unprefixed coordinators are distinguished by the complement they take (±verbal, ±CoP) and the possibility of being stacked up at least twice (±stackable). A prefixed coordinator has two of these three features switched from “−” to “+”, when compared with its unprefixed counterpart and thus see its ability to occur as the head of recursive coordination structures increased. The prefixao- is an operatorofrecursion.
Multiple Manufacturing Processing Target Value Setting Models: A Case Study on Grinding and Polishing Processes of the Electric Vehicle Motor Shaft
Authors: Chen Kuen-Suan , Hung Yung-Hsiang , Su Yuan-Tsung
Published: March 2022

Aiming to reduce the social-economic loss caused by deficient products, the processing target value setting requirements must be achieved through multiple manufacturing processes. Meanwhile, the processing target value setting for each step must properly match its own manufacturing process capability so as to lower the ratios of process scrap and rework. Consequently, the quality of the final product can be ensured to reduce social-economic loss, such as carbon emissions caused by faulty maintenance after sales. By means of the production data analysis as well as quality engineering, this study discovered the best conditions for multiple manufacturing processes and then adopted the genetic neural networks method to estimate the optimal stable-process standard deviation for each processing step. Next, according to the aforementioned optimal process standard deviation, the reasonable target value of each processing step was determined by the processing target value and the process capability set in the final product. Finally, this study provided the multiple-process capability analysis chart to evaluate the process capability after experiment. The processing of the green electric vehicle motor was taken as an example to explain the application of the reasonable processing target value setting model mentioned in this study.
EDITORIAL
Authors: Iriondo Otero Walter Ruben
Published: March 2022

A Equipe Editorial tem o prazer de apresentar um novo número da Revista Prociências, correspondente à última publicação regular da Revista para o ano 2021. As contribuições que compõem esta edição foram submetidas por investigadores do Brasil e do Exterior, notadamente, da Colômbia, México, e dos Estados brasileiros da Bahia, Espírito Santo, Pará, Rio Grande do Sul, e Santa Catarina.

Os artigos que integram o presente número apresentam resultados de pesquisas que versam sobre diversos desafios contemporâneos, na esfera do sistema educativo e no âmbito da gestão organizacional. Referente ao sistema educativo, apresentam-se investigações que abordam a aprendizagem no ensino superior baseada em problemas; a robótica educacional com foco em pessoas neurodiversas; os jogos e o transtorno do espectro autista; e a escala comum de valores em grupos de aprendizagem na educação a distância. Com respeito à abordagem direcionada às questões de gestão organizacional, incluíram-se nesta edição trabalhos que tratam da melhoria do processo de corte de tecidos na indústria têxtil; da gestão patrimonial de bens móveis; e do sistema de gerenciamento de atendimentos em instituições financeiras.

Cabe lembrar que a Revista Prociências aceita propostas da comunidade científica internacional para publicação de Edições Especiais, no formato Dossiê ou Edição Temática. Também vale mencionar que a Revista recebe contribuições em fluxo contínuo durante o ano todo, ou seja, é ininterrupto o recebimento de propostas e artigos inéditos para as próximas edições da Revista.

Assim sendo, reafirma-se o compromisso desta Equipe Editorial com a divulgação do conhecimento científico e com um projeto editorial interdisciplinar de qualidade, somado ao desejo de uma profícua leitura desta edição da Revista Prociências.

 

Walter R. Iriondo Otero

Editor
UM MAPEAMENTO SISTEMÁTICO SOBRE JOGOS PARA CONSCIENTIZAÇÃO SOBRE O TRANSTORNO DO ESPECTRO AUTISTA
Authors: De Brito Santana Beatriz , Costa Santana Kayo , Pinto Pereira Claudia
Published: March 2022

O presente trabalho visa apresentar um mapeamento sistemático elaborado como uma das etapas para a construção de um jogo sério (Vida Especial), voltado para a conscientização de pessoas neurotípicas sobre o Transtorno do Espectro Autista (TEA). Para tanto, foram levantados trabalhos em diferentes bases científicas, para verificar a abrangência desta temática e para levantar a existência de jogos com esse propósito. No total, foram analisados 202 estudos, sendo selecionados 40 trabalhos ao final das análises empregadas. Os resultados apontam que, embora existam estudos voltados para o diagnóstico, aprendizado e rotina do indivíduo com TEA, ainda há uma lacuna em tecnologias digitais voltadas para a conscientização dos indivíduos neurotípicos, sendo este um importante recurso para o fortalecimento da inclusão social de pessoas com autismo.
ALINHAMENTO OPERACIONAL DO SISTEMA DE GERENCIAMENTO DE ATENDIMENTOS EM UMA INSTITUIÇÃO FINANCEIRA
Authors: Schons Liana , Medianeira Bolzan Larissa , Iriondo Otero Walter Ruben
Published: March 2022

A unidade de análise dessa pesquisa é uma agência bancária localizada na região Sul, do Rio Grande do Sul. As agências bancárias oferecem serviços como crédito, investimento, poupança, consórcio, seguro, entre outros. Tais serviços estão-se tornando cada vez mais competitivos, e exigem que os sistemas de informação (SI) forneçam soluções para a administração do fluxo de pessoas. O trabalho teve como o objetivo alinhar operacionalmente o SI Sistema de Gerenciamento de Atendimento SAT aos processos organizacionais de uma agência bancária. O trabalho consiste em um estudo de caso, de natureza exploratória, e abordagem qualitativa com caráter descritivo. Para coleta de dados, foram utilizadas três técnicas, entrevistas semiestruturadas, observação participante, e a análise documental. Analisando o uso das funções disponíveis no SAT, foi possível verificar que, por vezes, o sistema é subutilizado. Para contornar tal problema, foram sugeridas onze mudanças no sistema de informação, de forma tal a adequar ao cliente o software adotado pela à organização.
Los Senderos del Tercer Kirchnerismo: Equilibrio Económico, Estabilización Política y Profundización Social
Authors: Barbosa Sebástian , Barros Eduardo
Published: March 2022

La política nacional en la Argentina actual puede ser caracterizada a partir del análisis de las formas de construcción y ejercicio de la hegemonía del kirchnerismo como sector de expresión del peronismo. Esta caracterización puede ser explicada en función de los desafíos, tensiones y límites del ejercicio efectivo de la propia coalición respecto a su liderazgo, sus políticas públicas y sus modalidades de ejercer el poder. En este sentido, se considera que el sendero del tercer kirchnerismo va a estar signado por el peso de la organización, la transición en el liderazgo y la dinámica interna del peronismo, el papel opositor, el rol de la economía y la “profundización” delmodelo. La forma de abordaje de estos puntos permitirá trazar un cuadro de la política nacional de los últimos años y esbozar algunas cuestiones frente al tercer período de gobierno kirchnerista.
Democracia y Populismo en Sudamérica
Authors: Lara Ignacio Fernando
Published: March 2022

El presente lavoro se plantea un doble objetivo: entender el modo en el cual se ha propuesto el estudio de las nuevas democracias latinoamericanas – los límites de dichos análisis – y clarificar la relación entre el populismo y la democracia, para poder comprender si el primero significa un retroceso en la consolidación democrática o si puede ser entendido como una mejora en la calidad de estas sociedades. Se concluidrá que la democracia se ha afirmado en términos de institucionalización de las elecciones y de las libertades políticas necesarias para el funcionamiento del régimen, mientras permanecen desafíos importantes en cuanto a los derechos sociales y civiles de los ciudadanos. A su vez, no se puede hablar de un retroceso en el proceso de consolidación democrática a causa del populismo, ya que el análisis de los regímenes populistas presentan sea progresos que desafíos para el desarrollo de la democracia, y sólo la profundización de éstos últimos podría eventualmente poner en tela de juicio la democracia.
Ectopic Fat Depots: Physiological Role And Impact On Cardiovascular Disease Continuum
Authors: Bragina Anna E. , Tarzimanova Aida I. , Osadchiy Konstantin K. , Rodionova Yulia N. , Kudryavtseva Maria G. , Jafarova Zarema B. , Bayutina Darya А. , Podzolkov Valeriy I.
Published: March 2022

Obesity is a non-infectious pandemic. The visceral distribution of adipose tissue is a significant factor in the development of cardiovascular diseases and their complications. Along with the visceral abdominal depot in omentum and subcutaneous tissue, there are other ectopic adipose tissue depots: epicardial adipose tissue (EAT), perivascular adipose tissue (PVAT) and perirenal adipose tissue. This article presents a review of the physiological role and molecular basis of the PVAT and EAT function in healthy, as well as in pathological, conditions; the interaction of adipokines and cytokines, their contribution to the development and progression of cardiovascular diseases. The review discusses well-known facts and controversial issues in this field. Comprehensive investigation of the mechanisms of vascular and myocardial pathology in obese people, along with identification of biomarkers for early prediction of cardiovascular complications, would contribute to the development of targeted preventive measures and choice of therapeutic strategies, which is consistent with the contemporary concept of personalized medicine. We have analyzed domestic and foreign literature sources in eLIBRARY and PubMed scientific libraries for the period of 2001-2020.
Functional Condition Of Inspiratory Muscles In Obstructive Sleep Apnea Patients
Authors: Miroshnichenko Anastasia I. , Kunarbaeva Adel K. , Ivanov Konstantin M. , Miroshnichenko Igor V. , Achkasov Evgeniy E. , Bondarev Sergey A. , Bezuglov Eduard N. , Popov Alexey A. , Gridin Leonid A. , Butko Dmitry Yu.
Published: March 2022

Background — Recurrent upper airway obstruction during the sleep is a key feature of obstructive sleep apnea (OSA). In patients with OSA, an intermittent upper airway obstruction yields an increase in inspiratory effort and, consequently, an augmented impact on inspiratory muscles (IM). However, the issue of IM fatigue development in OSA patients is still controversial. Objective — to investigate the functional condition of IM in patients with OSA of various degrees of severity. Material and Methods — Were examined 82 men (30-65 years old), who were distributed among four groups depending on the OSA severity. Cardiorespiratory monitoring was performed to detect OSA. IM electrical activity was detected via surface electromyography (EMG) while holding the breath (during the inhalation). Results — In the course of our study, we detected a reduction in the frequency of EMG of accessory IM, specifically sternocleidomastoid muscle (SCMM) and external intercostal muscles (EIM), accompanied by a simultaneous increase in the amplitude of EMG of SCMM, EIM, and diaphragm (D), while holding the breath (during the inhalation), in the group of patients without OSA. In patients with mild OSA, when holding the breath during the inhalation, the frequency of EMG of SCMM and EIM decreased, while the amplitude of SCMM and EIM increased. In patients with moderate OSA, when holding the breath during the inhalation, a decrease in the frequency of SCMM EMG with a simultaneous increase in the amplitude of the EIM EMG were revealed. Same maneuver in the group of patients with severe OSA yielded no significant changes in the frequency and amplitude of EMG of respiratory muscles. Conclusion — Periodic obstruction of the upper airways with OSA leads to the development of fatigue resistance in accessory IM.
Using Transcranial Magnetic Therapy In Combination With Electrostimulation For Correcting Neuroendocrine-Immune Disorders In Obese Boys
Authors: Bolotova Nina V. , Filina Natalia Yu. , Kurdiyan Margarita S. , Kompaniets Olga V. , Garifulina Lilya M. , Meshcheryakova Irina Yu.
Published: March 2022

Objective — To justify the use of low-intensity transcranial magnetic therapy (TCMT) in combination with electrostimulation (TES) for the correction of neuroendocrine-immune disorders. Material and Methods — Fifty adolescent boys with exogenous constitutional obesity 13-15 years of age were examined. The control group consisted of 30 boys aged 13-15 years without obesity and concomitant pathology. The examination included an assessment of complaints, anamnesis of the disease, life history, objective data, hormonal status, neurotransmitters and cytokines. By random sampling, the group of obese children was divided into two subgroups: subgroup 1a (n=24), who received TCMT in combination with TES, and subgroup 1b – comparison group (n=22), who received placebo therapy with disconnected electrodes. Both groups of children received identical recommendations regarding the nutrition. The effectiveness of the therapy was evaluated after 3 months. The treatment course comprised 10 procedures. Statistical processing of the obtained data was carried out using the statistical software package Statistica 8. Results — An increase in the levels of testosterone and β – endorphin as well as a decrease in estradiol and kisspeptin, which was accompanied by a decrease in body weight was observed in children of subgroup 1a (n=24) under the influence of TCMT in combination with TES. In subgroup 1b (n=22) receiving placebo therapy with disconnected electrodes, there was also a decrease in body weight, but at a much lower level. Conclusion — The use of TCMT in combination with TES led to the normalization of neuroendocrine-immune disorders and contributed to weight loss.
Water-Based Exercise Therapy And Improvement In The Motor Skills And Cognitive Function Of Children With Autism Spectrum Disorder: A Commentary
Authors: Faraji Sanaz , Najafabadi Mahboubeh Ghayour , Zandi Hassan Gharayagh , Parent-Nichols Jennifer
Published: March 2022

Background — Motor and cognitive dysfunction are common impairments experienced by children with a diagnosis of autism spectrum disorder (ASD). Objective: The main aim of this study was to present suggestions for the incorporation of water-based exercises in rehabilitation for the children with ASD. Methods — Researchers collected the current available data regarding novel methods of water-based exercise therapy for the children with ASD to address motor and cognitive function. Results — Children with a diagnosis of ASD face a number of common challenges that may be addressed by the utilization of aquatic therapy in their rehabilitation plan. Challenges commonly experienced by children with ASD may be addressed by properties of water and aquatic therapies. Presently, aquatic therapy is an underutilized resource as an intervention in the population of children with ASD. Conclusions — Water-based interventions is currently underutilized as a therapeutic intervention should be considered for individuals with a diagnosis of ASD.
Evaluating Some Parameters Of Wistar Rat Brain In Traumatic Brain Injury Model With Administration Of Proline-Containing Peptides
Authors: Kolesnikova Anna A. , Fleishman Marina Yu. , Malofey Yulia B. , Yakusheva Natalya Yu. , Tolstenok Ivan V.
Published: March 2022

Objective — To examine the morphometric parameters of neurons and the oxidative status of the Wistar rat brain tissues after administering proline-containing peptides, also known as glyprolines (Arg-Gly-Arg-Pro-Gly-Pro [RGRPGP] and Thr-Lys-Pro-Arg-Pro-Gly-Pro [WKPRPGP; Selank]), on a traumatic brain injury (TBI) model. Study subjects — Our study involved 26 mature male Wistar rats (2.5-3 mos. old, 220-300 g). The morphometric parameters of neurons and the oxidative status of animal brain tissues were studied. Material and Methods — Four experimental groups were formed. Group 1 included intact control animals. Animals in three other groups were subjected to TBI via free fall of a 50 g weight from a height of 50 cm on the second day of the experiment and received the following injections: 0.9% sodium chloride solution in Group 2; WKPRPGP peptide solution in Group 3; RGRPGP peptide solution in Group 4. Substances were administered intraperitoneally on a daily basis at a dose of 0.1 mg/kg from day 1 through day 5 of the experiment. Morphometric parameters of rat brain neurons were studied on paraffin sections stained with hematoxylin and eosin. The intensity of free radical processes in the brain tissue was investigated by chemiluminescence. Results — An analysis of morphometric parameters revealed significant increases in the neuronal cytoplasm area, nucleolar area, number of nucleoli, and nuclear-nucleolar index with the introduction of the RGRPGP peptide after TBI, compared with the WKPRPGP peptide under the same conditions. After TBI and peptide administration, we observed an oxidative stress in the neocortex of Wistar rats, and it was more pronounced in the group of animals treated with RGRPGP. Conclusion — After RGRPGP peptide administration, we observed an increase in the morphometric parameters of neurons in the closed TBI model: a larger area and a greater number of nucleoli. Chemiluminescence data implied that WKPRRPGP peptide better protected brain tissue in rats from the effects of oxidative stress caused by TBI.
Reproducing Morphological Features Of Intervertebral Disc Using Finite Element Modeling To Predict The Course Of Cervical Spine Dorsopathy
Authors: Yakovlev Evgeny V. , Ovsepyan Artur L. , Smirnov Alexander A. , Safronova Anna A. , Starchik Dmitry A. , Zhivolupov Sergey A. , Vasil’ev Yuriy L. , Dydykin Sergey S.
Published: March 2022

Study objective — To evaluate how morphological features of intervertebral disc would affect the outcomes of finite element modeling of axial load in the cervical spine, C3-C5, in order to predict the risk of occurrence and course of dorsopathies. Material and Methods — Three-dimensional models of the cervical spine vertebrae were generated from the computed tomography data of a volunteer (24 years old male without detected pathology of his neck). Intervertebral disc models were developed in two configurations. For each model, we performed a finite element investigation of the stress-strain state with the same loading conditions. The load-displacement curves were compared with the experimental data generated from the results of previously conducted in vitro experiments. Results — The maximum and mean displacement values for the isotropic model were 1.15 mm and 0.73 ± 0.45 mm, respectively. For anisotropic model, maximum and mean displacement values were 0.86 mm and 0.47 ± 0.24 mm, correspondingly. Predicted displacement values for both models matched the experimental data fairly well. Stress profiles of intervertebral discs and stress diagrams of facet joints were calculated. Conclusion — The proposed geometric and constitutive configurations of the intervertebral disc take into account specific morphological features at low computational costs, thereby facilitating the modeling of degenerative disc changes.
Fluid Retention In The Pulmonary Circulation As A Cause Of Pulmonary Vein Dilatation And Atrial Fibrillation Development In Chronic Heart Failure Patients
Authors: Kirillova Venera V.
Published: March 2022

Objective — The study objective was to perform a transthoracic echocardiographic study of the remodeling of the left atrium and the maximum and minimum diameters of pulmonary veins, as well as remodeling regression in the process of heart failure treatment, in patients with chronic heart failure (CHF) and different forms of atrial fibrillation (AF). Material and Methods — The prospective study included patients having CHF with paroxysmal AF (n=38) and permanent AF (n=36) and without arrhythmia (n=225); the patients had their maximum and minimum diameters of the pulmonary vein measured, additionally to the standard echocardiographic protocol, before and after six months of standard therapy including a loop diuretic. Results — Structural changes in the left atrium and pulmonary veins of patients with CHF having permanent atrial fibrillation were significantly more distinct than those in patients with paroxysmal AF, in patients without arrhythmia, and in the control group. A decrease in the maximum and minimum diameters of the pulmonary vein followed by termination of AF attacks within a year of observation was detected after CHF treatment with a loop diuretic in patients with paroxysmal AF and permanent AF. Conclusion — Prescribing loop diuretics to patients with pulmonary vein dilatation detected during transthoracic echocardiography in subjects with paroxysmal AF and permanent AF results in a decrease in PV diameters and termination of AF attacks in paroxysmal AF.
Numerical analysis of wake turbulence between hybrid tidal turbine and hypothetical actuator cylinder for shallow water with low velocity conditions
Authors: Dass Lakshuman , Abdul Rahman Anas , Rajendran Kumaran , Suhri Gisrina Elin
Published: March 2022

Towards  modernisation of the technological era, electricity demands have been an issue. Although the supply of electrical energy from the renewable sources are increasing, it is still not sufficient to offset the carbon production. Malaysia as a developing country needs ample of supply of electrical energy. As most of the current electrical energy for the country are being produced by non renewable sources, the Malaysian government have started looking into renewable options to produce electrical energy. There are various sources of energy that are available in Malaysia such as solar, natural gas, petroleum, ocean energy and many more. This paper is focused on the tidal energy which is an ocean energy that can produce electrical energy by using the power of tide. This research explores the hybrid turbine design which is a type of vertical-axis tidal turbine that combines two distinct type of devices, namely Savonius and H-Darrieus turbines. Hybrid turbine is useful as it helps to overcome the limitation of individual turbine and also be able to produce energy at a low water velocity. Numerical analysis is employed to investigate the wake recovery behaviour and turbulent mixing due to the positioning of the device using Ansys CFD Fluent. By understanding the general wake characteristics produced by each device, proper planning can be done to configure these devices in an array for future planning. The simulation result shows that the hybrid turbine utilising NACA0015 and NACA0018 with nested configuration demonstrates faster velocity recovery compared to NACA0021. The turbulence wake results also provides a promising output which shows the acceleration of flow at the downstream region for hybrid nested NACA0015 and NACA0018 are more narrow compared to NACA0021. The result of this simulation has also been validated with published data. In a nutshell, the NACA blade design not only affects the performance of the turbine but can also influence the velocity recovery downstream of the device.
Development of non-linear models to evaluate the NiTi SMA spring actuator
Authors: Singh Deep , Choudhury Rutupurna , Mukherjee Manidipto , Singh Yogesh
Published: March 2022

The shape memory alloy (SMA) based actuators are replacing huge and bulky actuators because of its ability to provide high work per unit mass and serves as active prismatic joint to develop precise robotic manipulators. It also helps in developing a light weight manipulators with a simple actuation process. Here, the study presents the relationship between the contraction of Nitinol SMA prings and the input variables such as current and time to effectively interpret the behavioural complexity. In addition, the response of two Shape memory alloy springs in series combination has been discussed. The finite element analysis (FEA) of the SMA wire and spring has also been carried out to predict the fatigue life of SMA wire and spring. The result showed that the contraction rate of SMA spring increases with increase in current and vice-versa. Moreover, the range of current is classified based on its significance. The relationship of current, displacement and time parameters, during the actuation of SMA spring, is a second order polynomial regression model. The applied current and time have positive impact on the contractiong rate of SMA. Several polynomial regression models were developed in order to predict the precise amount of spring actuation. This study also predicts the range of current suitable for its actuation based on its application as actuator. The FEA result shows that the SMA springs can have high endurance stress limit which makes it unique as compared to other commercially available actuators. This study enables to predict the rate of contraction and the deflection trend of SMA based actuators for precise positioning applications.
OpenRefine: An Approachable Open Tool to Clean Research Data
Authors: Miller Meg , Vielfaure Natalie
Published: March 2022

This review provides an overview of data cleaning tools and discusses why and how OpenRefine has been an effective tool in the delivery of one-shot instructional sessions on data cleaning in an academic library context.
Developing and Delivering a Comprehensive Vaccine COVID-19 Program: RapidVax
Authors: Siminoff Laura A. , VonNessen-Scanlin Susan , Wu Huanmei , Richardson Briana , Kelly Patrick , Bauerle Bass Sarah , Chansiri Karikarn
Published: March 2022

RapidVax was developed in January 2021 to provide COVID-19 vaccination across Temple University’s College of Public Health (CPH). The scale-up phase of the project was an inter-professional effort to develop specific messaging about COVID-19 vaccination and delivered vaccination to communities in Philadelphia, esepcially vaccine-hesitant individuals and marginalized groups with limiteded access to health services. Emphasizing community engagement, evidenced-based message designs, and vaccine delivery, RapidVax has resulted in 1,542 individuals within the CPH and Temple, 2,685 of the general public vaccinated, of which approximately 74.9% were people of color and 16% were homeless (total doses given to date is 7,445). RapidVax, as an interprofessional collaboration between nursing, social work, pharmacy, and public health practitioners, is a promising model to deliver vaccination and decrease disparities.
Operating Bias?: Racial and Ethnic Disparities in Surgical Specialties
Authors: Kling Sarah , Taylor George , Kuo Lindsay
Published: March 2022

Health care disparities are defined as differences in quality and rates of health, health care, morbidity, and mortality among patients of varying racial or ethnic groups. Racial and ethnic disparities are unfortunately pervasive in the surgical literature and among surgical specialties. They may result from any combination of patient, societal, system, and provider-related factors. Disparities exist in relation to health care access, treatments, and post-operative outcomes. Potential ways to better address and rectify racial and ethnic disparities are through continued research into causes of disparities, as well as establishment, implementation, and adherence to standardized, objective treatment guidelines. Significant and continued efforts are needed in order to develop better understanding of and potential solutions for reducing these disparities.
Cannon Stored in Hugo Scheu Museum in Šilutė. Analysis of Artillery Cannons According to XRF Research Data
Authors: Vasiliauskas Liudvikas
Published: March 2022

The article discusses the Swedish 3 pounds regimental cannon, produced in 1786.X-ray fluorescence (XRF) chemical element analysis data from cannon barrel alloys are also presented and discussed. As well as influence of their composition on the operation of cannons.
Influence of electromagnetic protection technology on human psychophysiological condition
Authors: KG Korotkov , EA Gavrilova , OA Churganov , JJ Machado
Published: March 2022

Objectives: This study aimed to demonstrate the beneficial effect of Noxtak electromagnetic protection technology on human psychophysiology. Design: An open, randomized, placebo-controlled trials for 30 days. Participants were measured initially, randomly divided into two groups (experimental and control), and measured 30 days later after using Noxtak technology in the experimental group and placebo in the control group. Subjects: 50 healthy athletes, age 14-25 years, men and women, randomly divided into two groups of 25 people. Randomization was based on the principle of random numbers. The ethics committee of the Federal State Budget Institution "Saint-Petersburg Scientific-Research Institute for Physical Culture," St. Petersburg, Russia, approved the study protocol. All participants signed an informed consent form, where a written and oral explanation of the research protocol was provided. Outcome measures: psychological testing, rhythmocardiography, biofield parameters analysis. Results: Participants using Noxtak electromagnetic protection for 30 days demonstrated positive changes in psychophysiology parameters, experienced growth in aerobic capacity, physical performance, energy potential, and their bodies' adaptive reserves, while physiological parameters of athletes using placebo did not change or worsened. Conclusions: Participants using Noxtak technology for 30 days demonstrated improvement of psychophysiological parameters and sleep quality, which may be related with the protection effect from electromagnetic radiation
Еffect of fullerene C60 on the diffusion of organic solvents' molecules
Authors:   Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Slisenko V.I. , Vasylkevych O.A.
Published: March 2022

The results of studying the dynamics of molecules of solutions of fullerene C60 in benzene and toluene are presented. The studies were carried out by the method of quasi-elastic scattering of slow neutrons. The following were determined: the total self-diffusion coefficient D, its collective Dcoll and single-particle Ds-p contributions, and molecule relaxation time τ0 before and after the dissolution of fullerene. It is necessary to pay attention to the fact that in our case a kind of neutron contrast experiment takes place. The significant difference (more than ten times) in the cross-sections for an incoherent scattering of neutrons by hydrogen and carbon nuclei made it possible to obtain diffusion parameters that characterize the dynamics of solvent molecules exclusively. It turned out that the intensity of diffusion movements of solvent molecules is almost ten times higher than the mobility of fullerene molecules.
Effect of additional "clean" feeding on 90Sr and 137Cs content in prussian carp (Carassius gibelio) in the Chornobyl exclusion zone
Authors:   Ukrainian Institute of Agricultural Radiology, National University of Life and Environment Sciences of Ukraine, Kyiv, Ukraine, Pavlenko P.M. , Kashparova O.V. , Levchuk S.Ye. , Hrechaniuk M.O. , Gudkov I.M. , Kashparov V.O. ,   Center for Environmental Radioactivity, Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences, Ås, Norway
Published: March 2022

Under natural conditions, in one of the most radioactively contaminated water bodies of the Chornobyl exclusion zone, lake Glyboke in 2020, experimental studies were carried out to assess the effectiveness of the use of additional "clean" feeding to reduce the levels of radioactive contamination of 90Sr and 137Cs in fish. The radiological efficiency of decreasing the 137Cs intake into the muscle tissue of fish with the use of additional "clean" feeding, mainly due to biological dilution, was 2.9 ± 0.4 times. The biological half-life of 137Cs in the muscle tissue of radioactively contaminated fish was 115 ± 25 days with the consumption of natural and additional "clean" food, which is approximately 2 times longer compared to the case when the fish consumes only clean food. In contrast to 137Cs, using additional "clean" feeding led to an increase of 90Sr content in the fish organism as compared to the control (up to 5 times) in proportion to the relative increase in the mass of fishbone tissue, which contains the bulk of strontium.
Two stages in the accumulation of 137Cs by mushroom Suillus luteus after the Chornobyl accident
Authors:   Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Zarubina N.E. , Burdo O.S. , Ponomarenko L.P. , Shatrova O.V. ,   National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", Kyiv, Ukraine,   SE “UKRMETRTESTSTANDARD”, Kyiv, Ukraine
Published: March 2022

Studies of the 137Cs content in fruit bodies of Suillus luteus in the territory of the Chornobyl exclusion zone and Kyiv region outside the zone were carried out during the period 1986 - 2020. It was found that the dynamics of 137Cs activity in the mushroom can be described as a two-stage process. The first stage since 1986 was characterized by the annual increase in levels of specific activity of 137Cs for the following 10 - 12 yrs. During the second stage, there has been a gradual decrease in concentrations of 137Cs. The ecological half-life of 137Cs in the mushroom at the second stage differs for different sampling sites. Its minimum values were noted at villages Yaniv and Novo-Shepelychy sampling sites inside the exclusion zone. The maximum of 137Cs ecological half-life in Suillus luteus was observed on the Rzhyshchiv sampling site, which is the most remote from the Chornobyl Nuclear Power Plant outside the exclusion zone.
Chromosome aberrations in human lymphocytes due to external and/or internal irradiation of blood samples by 137Cs in model experiments in vitro
Authors:   Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Kurochkina V.A. , Bezdrobna L.K. , Tsyhanok T.V. , Strilchuk M.V. , Maliuk I.A.
Published: March 2022

The linear dependence of the yield of unstable chromosomal aberrations in human lymphocytes on the dose of prolonged external and/or internal irradiation of peripheral blood samples by 137Cs in the dose range of 0.09 - 0.54 Gy in vitro is presented. The higher cytogenetic efficiency of internal 137Cs irradiation is shown in comparison with external. It is shown that the cytogenetic efficiency of 137Cs in blood contamination is caused by influence on cells not only in the mitotic rest phase but during proliferation, within intracellular radioactivity through their cultivation. It is proposed to use the presented dose dependences of the yield of chromosomal aberrations in lymphocytes in vitro for human biological dosimetry during radiation accidents associated with prolonged external exposure or 137Cs incorporation to the body as a supplement to the results of physical dosimetry.