bluuebunny/crossref_metadata_2025 huggingface dataset:
Abordagem à Infeção pelo Vírus Citomegálico em Doentes Submetidos a Transplante Alogénico de Progenitores Hematopoiéticos
Authors: Silva Fernando , Martins António , Ferraz Paula , Lopes Diogo , Bastos Juliana , Joana Araújo Joana Araújo , Trigo Fernanda , Pinto Ricardo , Silva-Pinto André
Published: July 2024

O vírus citomegálico (CMV) é um tipo de vírus de ácido desoxirribonucleico de dupla cadeia que pertence à família herpesviridae. Após uma infeção primária, o vírus torna-se latente em vários tipos de glóbulos brancos. A infeção por CMV pode permanecer latente ou tornar-se ativa, especialmente em indivíduos imunodeprimidos, como aqueles submetidos a transplantes de células progenitoras hematopoiéticas (TPH), onde a reativação do CMV pode ocorrer. Neste contexto, a infeção por CMV é comum e associada a elevadas taxas de morbilidade e mortalidade. A pneumonite é uma das complicações mais graves, com taxas de mortalidade superiores a 50%. Além disso, mesmo na ausência de doença específica do órgão, a infeção por CMV está relacionada com um aumento da mortalidade não relacionada com a recidiva da neoplasia hematológica. Dada a frequência e gravidade desta infeção em doentes submetidos a TPH, é crucial implementar estratégias eficazes de monitorização, prevenção e tratamento. Este protocolo foi desenvolvido para identificar os grupos de doentes que se beneficiam de uma abordagem sistematizada para a infeção por CMV e definir a estratégia mais adequada para cada grupo. A monitorização da carga viral de CMV no sangue periférico é fundamental, especialmente em doentes com risco moderado a elevado de infeção ativa. A profilaxia primária com letermovir (fármaco antiviral) é recomendada para reduzir a incidência de infeção ativa, especialmente em doentes com alto risco. A profilaxia secundária com valganciclovir (fármaco antiviral) é recomendada após um episódio de infeção ativa, enquanto o tratamento de antecipação e de doença é baseado na monitorização da carga viral e na resposta clínica. Este protocolo visa melhorar a abordagem da infeção por CMV em doentes submetidos a TPH, garantindo uma abordagem preventiva e terapêutica eficaz e segura.
Construção e validação de um questionário para mensurar a percepção de treinadores de judô brasileiros, quanto as regras de competição das categorias de base
Authors: Tavares Junior Antonio Carlos , Dos-Santos Júlio Wilson
Published: July 2024

Objetivo: construir e validar um questionário, para mensurar a percepção de treinadores de judô brasileiros quanto as regras de competição das categorias Sub-9, Sub-11, Sub-13 e Sub-15, considerando 4 fatores: Segurança, Especialização Esportiva Precoce, Preparação Desportiva de Longo Prazo e Alterações nas Regras. Metodologia: O questionário construído foi um Survey, com perguntas fechadas de escala Likert. A validação desse instrumento psicométrico passou por 3 etapas: validação do conteúdo, por juízes experts (cientistas da área de ciências do esporte), estudo piloto com 30 treinadores e análise da consistência interna com a participação de 166 treinadores, das 5 regiões do país. Resultados e discussão: O conteúdo foi avaliado por meio do Coeficiente de Validade de Conteúdo, com ponto de corte 0,80. A análise fatorial confirmatória foi utilizada para avaliar a consistência interna, sendo retirados os itens com carga fatorial inferior a 0,40. Conclusão: Considerando os processos de construção e validação do questionário podemos afirmar que ele atende aos objetivos de investigação sobre as regras de competição das categorias de base do judô brasileiro.
BUNNY CODE: INTERACTIVE EDUCATIONAL CODING GAMES FOR KIDS
Authors: Rahimi Muhammad Yazid Bin Noor , Rosdi Muhammad Zulhilmie Bin Mohamad , Zeki Akram M
Published: July 2024

This paper presents the analysis and design of a prototype system aimed at making coding engaging for individuals of all ages, from primary school students to seasoned learners familiar with the basics of programming. The primary objective is to enhance the accessibility and appeal of coding education across different age groups. The study begins by providing an overview of the Bunny Code project, outlining its scope and objectives. It describes the methodology employed, including the system architecture design, use case diagram, use case narratives, activity diagram, sequence diagram, and the prototype design. The comprehensive analysis and design process are detailed to provide insights into the development of an interactive coding learning platform. In addition to the technical aspects, this paper discusses the results of an online survey conducted to gather perspectives from the target user demographic. By incorporating user feedback into the design process, the study aims to ensure that the prototype system meets the needs and expectations of its intended audience. Ultimately, this research contributes to the field of educational technology by proposing innovative approaches to make coding accessible and engaging for learners of varying age groups. The findings and methodologies outlined in this paper serve as a foundation for the development of interactive and inclusive coding education tools, such as the Bunny Code platform.
Correlation of the Socio-Demographic Variables to Travel Behaviour and Mode Choice in Cities of Least Developed Countries- Case Study, Urban Neighbourhoods in Aden, Yemen
Authors: Al-Kaderi Abdulnasser Abdulla , Ali Suha Yaseen Abdulkarem
Published: July 2024

This case study focuses on the city of Aden, Yemen, where a large segment of the population relies on the semi-formal public transportation due to various sociodemographic and economic factors. The study specifically investigates the inner urban area of Al Mansoura in Aden. To understand travel behavior and mode choice in this area, the research employs a mixed methodology that combines qualitative and quantitative approaches through a case study design. Primary data about the area of interest were collected through field observations, interviews, questionnaires, GIS mapping, and street audits. In addition, a novel mapping of the semi-formal transportation lines was produced for the first time in the city. Both quantitative and qualitative data were analyzed using statistical analysis methods. The results indicate a correlation between sociodemographic variables and travel behavior and mode choice, particularly in terms of income and gender. Low-income individuals tend to use public transport, while those with higher incomes prefer private vehicles. Additionally, females generally drive less than males and generally have less mobility due to cultural and educational factors; fewer responsibilities outside the home. However, a small number of females who use private vehicles tend to work.
A Conceptual Educoach Multi-Sided Business Model: Online Tutoring Platform to Improve Career Opportunities of B40s and Unemployed Graduates as Digital Entrepreneurs
Authors: JAMALUDIN NAZURIN QAMARINA BINTI , KAMRAN ALYA AQILAH BINTI AHMAD , ABIDIN AISYAH NAJIBAH BINTI ZAINAL , SHAMSUDDIN SAKINAH BINTI , DAHLAN ABDUL RAHMAN BIN AHMAD
Published: July 2024

The paper discusses the development of EduCoach, an online tutoring platform aimed at supporting B40 university students in Malaysia, who come from families with monthly incomes below RM 4,850. EduCoach connects these students with qualified tutors for personalized, one-on-one academic assistance, aiming to enhance academic outcomes and student satisfaction. Despite competition from similar platforms, EduCoach emphasizes ensuring high-quality tutoring to stand out. It also offers tutors, especially B40 working adults and the unemployed, a chance to earn extra income and gain teaching experience, albeit with the need to manage their time effectively. Additionally, note sellers can monetize their academic materials, provided they maintain high standards of quality and organization. The platform adopts a design thinking approach to empathize with users, define problems, and prototype solutions, ensuring a user-friendly and effective service. EduCoach addresses the educational challenges faced by university students while offering flexible income opportunities for tutors and note sellers.
Review some engineering methods to facilitate basic mathematical operations
Authors: Sheet Lugen
Published: July 2024

The research reviews the most important engineering methods in basic mathematical calculations. In these methods, we will present several calculations, for example, the multiplication process and the division process between different quantities, to facilitate the arithmetic process for the primary and intermediate stages of school students. These methods are considered applied research to facilitate students’ memorization of multiplication and division tables.
HbA1c and Pulsatility Index in Middle Cerebral Artery of Patients with Acute Thrombotic Stroke
Authors: Rio Tasti Surpa Rahmat Bintan  , Sita Setyowati  , Yudhi Adrianto
Published: July 2024

Highlights:1. The findings of this study indicate that clinicians should remain vigilant, as effective glycemic control, reflected by optimal HbA1c levels, does not necessarily correlate with favorable distal cerebrovascular resistance, as measured by pulsatility index (PI).2. This study recommends that patients with acute thrombotic stroke undergo a comprehensive examination to ensure an accurate diagnosis and appropriate treatment.
 
Abstract
Stroke is the second leading cause of death and disability in the world. Diabetes mellitus is a risk factor for stroke with an increase in blood viscosity associated with hyperglycemia, and HbA1c is a well-established biomarker primarily used for the long-term monitoring of glycemic control in patients with diabetes mellitus. The Pulsatility index (PI) parameter of Trans Cranial Doppler (TCD) can measure blood vessel resistance. This study was to prove the correlation between HbA1c and PI in Middle Cerebral Artery (MCA) of acute thrombotic stroke patients. A cross-sectional study was conducted to thrombotic stroke patients treated at the neurological ward of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from March 2019 to April 2020 who met the inclusion and exclusion criteria. Data were obtained from medical records. Statistical analysis was performed using Spearman test for numerical data and Chi-square for categorical data with a significant value of p <0.05. There were 32 subjects who met the inclusion and exclusion criteria. A total of 24 subjects (75%) were males and 8 (25%) females with a mean age of 56.41±13.22 years. PI MCA results were abnormal in 14 subjects (43.75%) with an average of 1.8±0.97 and PI MCA was normal in 18 subjects (56.25%) with an average of 0.87±0.15. The average HbA1c was 6.55±1.9%. There was no statistically significant association observed between HbA1c and PI in MCA examination (r=0.07; p=0.73). In conclusion, the findings of this study indicate the lack of correlation between pulsatility index and HbA1c in patients with acute ischemic stroke. This underscores the importance of comprehensive cerebrovascular evaluation regardless of HbA1c status.
The Effects of Intermittent Fasting on the Size and Number of Subcutaneus Adipocytes in Obese Mouse Models
Authors: Veny Larasati  , Riana Sari Puspita Rasyid  , Soilia Fertilita  , Tri Suciati  , Muhammad Farhan
Published: July 2024

Highlights:1. This study helps bridge the gap between systemic effects and tissue-level changes, providing a deeper understanding of how histological analysis can be used to explore the effects of intermittent fasting on adipocytes and body weight regulation.2. This study contributes to obesity management through lifestyle modification, specifically intermittent fasting, by focusing on histological changes in adipose tissue.
 
Abstract
The accumulation of adipose tissue can have deleterious effects and lead to obesity. Intermittent fasting (IF), an approach that involves time-restricted eating, has gained popularity as an obesity treatment option because it enhances insulin sensitivity and promotes beneficial changes in glucose metabolism. This study used a time-restricted meal intake (TRM) approach to assess the effects of IF on the histological features of obese mouse models' subcutaneous inguinal adipose tissue. The investigation employed an in vivo experimental posttest-only control group design. Twenty male mice were divided into four groups: a normal control group, an obese control group, a TRM group with a high-fat diet (TRM-HF), and a TRM group with a standard diet (TRM-S). The TRM treatment was administered for fourteen days, with a fasting window from 4 p.m. to 8 a.m. The pre- and post-treatment weight analyses were conducted using the paired t-test for normally distributed data and the Wilcoxon test for non-normally distributed data (p<0.05). One-way analysis of variance (ANOVA) was employed for unpaired data on the post-treatment weight. Per field of view, there were an average of 120,500 cells (49,700–136,200) in the normal control group, 68,380±9,194 cells in the obese control group, 70,860±11,029 cells in the TRM-HF group, and 79,360±5,112 cells in the TRM-S group. The average cell sizes (Î¼m3) were 56,730.142±19,273.257 in the normal control group, 138,934.331±27,670.558 in the obese control group, 106,827.767±20,580.501 in the TRM-HF group, and 68,689.114±8,219.727 in the TRM-S group. The number of cells in each group did not differ significantly, but there were significant variations in cell size. The mice receiving TRM treatment did not exhibit substantial body weight changes, whereas the obese control group showed a significant body weight increase. In conclusion, TRM has an effect on cell size but does not affect the quantity of adipocytes in subcutaneous inguinal fat tissue.
Serological Profiles of Systemic Lupus Erythematosus in Humanized Mice and Pristane-Induced Lupus Models
Authors: Syahrul Chilmi  , Dimas Ikhsan Airlangga  , Hani Susianti  , Kusworini Handono
Published: July 2024

Highlights:1. This study compared the serological markers of pristane-induced mice to humanized mouse models of lupus achieved by transplanting stem cells from lupus patients, which is a novel method in Indonesia.2. This study will allow for more accurate research into the pathophysiology of the disease and the development of new lupus treatment strategies.
 
Abstract
More studies related to systemic lupus erythematosus (SLE) therapy are urgently needed because of the current insufficiency in treatment effectiveness. However, due to ethical limitations, researchers use experimental animals as a substitute for conducting studies on humans. Models commonly used to study lupus include the pristane-induced mouse model and the recently developed humanized mouse model. The second model involves implanting human immune cells into immunodeficient mice. This study compared the serologic profiles of lupus antibodies, the antinuclear antibodies (ANA) and anti-double stranded DNA (anti-dsDNA), in both mouse models. The aim was to determine which one is more promising for use as a lupus animal model. Thirty BALB/c mice (Mus musculus) were used as subjects and divided into three groups: K1, K2, and K3. K1 served as the control group, consisting of healthy mice that received a placebo. The K2 mice were intraperitoneally injected with 0.5 cc of pristane. The K3 mice were transplanted with stem cell cultures from SLE patients, resulting in humanized mice with immune deficiencies. The mice were observed for 16 weeks, during which the ANA and anti-dsDNA levels in their serum were obtained for analysis using the Kruskal-Wallis test (p<0.05). The comparison revealed differences in the average ANA and anti-dsDNA levels among the three groups. K3 had the highest ANA and anti-dsDNA levels, followed by K1 and K2. The Kruskal-Wallis test indicated that the differences were not significant in the mean levels of ANA (p=0.156) and anti-dsDNA (p=0.061). In conclusion, the humanized mouse model has higher ANA and anti-dsDNA antibody levels compared to the pristane-induced mouse model, albeit without a significant difference. This suggests a positive picture of the humanized mouse model of lupus, making it an invaluable tool for studying the disease and testing potential therapeutic interventions.
Effects of Minocycline as a Neuroprotective Agent for Stroke on Mmp-9 Levels, Functional Outcome, and Mortality
Authors: Ayu Imamatun Nisa  , Arlia Ayu Damayanti  , Jeffri Nagasastra  , Abdulloh Machin  , Mohammad Fathul Qorib  , Retnaningsih  , Baarid Luqman Hamidi
Published: July 2024

Highlights:1. As minocycline plays an important role in stroke microglia activation and iron chelation, it is important to further analyze its effects on stroke treatment.2. This meta-analysis revealed a significant effect of minocycline therapy, as evidenced by improved functional outcomes and inhibited matrix metalloproteinase-9 (MMP-9) activity.
 
Abstract
Stroke is the most common and devastating cerebrovascular disease. Many neuroprotective medications, such as scale and minocycline, have been developed to help the nervous system recover or regenerate after a stroke. However, it remains unclear whether minocycline provides a beneficial effect on stroke. We conducted this systematic review and meta-analysis to synthesize the effects of minocycline in stroke treatment. The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), with registration number CRD42023485168. The quality of the eligible studies was assessed using the Jadad scale. This systematic review included three ischemic stroke trials, seven intracerebral hemorrhage trials, and one study on acute stroke. There was a significant association between minocycline intervention and stroke severity according to the National Institute of Health Stroke Scale (NIHSS), with a pooled mean difference (MD) of -1.92, a 95% confidence interval (CI) of -3.39 to -0.45, and a value of p=0.01. In the subgroup of ischemic stroke, the modified Rankin Scale (mRS) was significantly lower in the minocycline treatment group compared to the control group (MD=-0.89, 95% CI=-1.54 to -0.25, p=0.007). Additionally, matrix metalloproteinase-9 (MMP-9) levels for the intracerebral hemorrhage subgroup were significantly lower in the minocycline treatment group compared to the control group (MD=-19.93, 95% CI=-36.9 to -2.96, p=0.02). The analysis revealed that minocycline intervention was not significantly associated with hematoma volume, mortality, or stroke recurrence. Our findings indicate that minocycline supplementation is a potential intervention strategy for treating ischemic stroke and intracerebral hemorrhage.
ASSISTING OF NUANSA GEMBIRA COFFEE PRODUCTS TOWARDS HALAL CERTIFICATIONS WITH THE SI-HALAL APPLICATION IN DELES VILLAGE, BATANG DISTRICT, CENTRAL JAVA
Authors: Afiati Lely , Verawati Liesta , Anwar Muhamad
Published: July 2024

A halal certificate is a legal requirement that must be fulfilled for every Micro, Small, and Medium Enterprise. Kopi Nuansa Gembira is a pure, original ground coffee business without any mixtures which still does not have halal certification. The problems faced will result in distrust and sales volumes that continue to decline if this is still ignored. This service is carried out to help Nuansa Gembira Coffee to obtain a halal certificate. The lack of understanding regarding halal products makes it necessary to provide assistance and knowledge to Kopi Nuansa Gembira. The solution offered is in the form of aid related to halal certificates and obtaining halal certificates. The stages of halal product assistance are: The preparation stage is surveying the service location to explore the problems faced by Nuansa Gembira coffee. Phase 1, the service team and the owner of Nuansa Gembira Coffee went to the Ministry of Religion office to consult regarding halal products. Stage 2 prepares all the necessary documents. 4. Sustainability Phase of issuing a halal certificate for Kopi Nuansa Gembira. The assistance results will start from January 2023, namely when the initial assistance starts from preparations for verifying problems with partners to convincing the owner of Kopi Nuansa Gembira to apply for halal certification through the halal application. The business actor then fills it out and submits it after filing and filling in the complete documents. After going through all the processes, including the verification, validation, and return processes, both by the companion and by BPJPH, on June 9, 2023, the halal certificate for Kopi Nuansa Gembira was issued.
TRAINING OF TRAINERS FOR CLASS TEACHERS TO IMPROVE STUDENTS ORAL HYGIENE IN MIN 2 KEDIRI
Authors: Khafid Mohammad , Putri Annisa
Published: July 2024

Dental caries in Indonesia is a dental health problem that still needs attention. Dental plaque accumulating in the oral cavity can increase the risk of dental caries. To date, brushing your teeth is the most effective effort to remove plaque regularly. It is known that the School Health Program (SHP) has proven effective in increasing students' knowledge, motivation, and skills in brushing their teeth. However, an active role is needed from parents and the school, especially class teachers, to support this SHP program. Therefore, training is needed for class teachers who will later become trainers for students on how to brush their teeth properly and correctly. SHP was carried out on 60 class teachers at Madrasah Ibtidaiyah Negeri (MIN) 2 Kediri in July-August 2023. Participants were given training on how to brushing teeth correctly by the dentists through Focus Group Discussion (FGD) activities and then taught the participants training materials to students in their respective classes for one week. Evaluation of the success of the program was carried out on students one week after the students were taught by their teachers. The result showed that students were able to answer the questionnaire correctly and had optimal oral hygiene. Based on the results, it can be concluded that the training of trainer program on how to brushing teeth for teachers can increase student's knowledge, motivation and ability to maintain oral hygiene.
HYPERTENSION AS A SILENT KILLER DISEASE: EDUCATION FOR AT-RISK COMMUNITIES IN PEKUWON VILLAGE
Authors: Zethira Andini Tania , Hendrati Lucia , Diyanah Khuliyah , Pawitra Aditya , Jasmine Meuthia , Syahputri Remit , Alvionita Annisa , Khaerati Mutmainah , Bratajaya Kusuma , Prabasanti Mezaluna , Suryanegara Elang , Rahayu Az-Zahra , Liviansyah Nabilla , Arif Muhammad , Siregar Fitri
Published: July 2024

Hypertension is often called a silent killer disease because it does not give symptoms to the affected person. Bojonegoro Regency in East Java is one of the areas with a high rate of non-communicable diseases, reaching 385,465 people. Pekuwon Village in Bojonegoro Regency is one of many areas with high hypertension problems. An education program is needed to increase knowledge about hypertension as a disease that can come unexpectedly. The target of this education program is the people of Pekuwon Village aged 15-59 years. The hypertension education program was carried out during the Posbindu PTM activity in Pekuwon Village which was attended by 39 participants. The speaker of the education program was a village cadre who had been trained by the community service team of the Faculty of Public Health, Universitas Airlangga. The evaluation used pre-test before giving information and post-test after giving information. The results showed an increase in knowledge from 63.63% to 97.43%. These results meet the program's success indicators, namely a 30% increase in knowledge in the Pekuwon Village community.
GOVERNMANET PUBLIC RELATIONS IN FACING POLITICAL YEAR: TRAINING FOR LOCAL GOVERNMENT OF MAGETAN
Authors: Suteja Rani Sukma Ayu , Rahayu Titik Puji , Wahyudi Irfan , Widodo Suko , Septiani Dina , Isnaini Santi , Fitranisa Intan , Puspa Ratih
Published: July 2024

The issues faced by Indonesia in the 2019 elections are likely to reemerge in the 2024 elections. In the 2019 elections, digital media became a highly effective tool for disseminating information related to politics and governance. Unfortunately, not all information available on digital media was accurate. Social media, in particular, saw a lot of misinformation and the spread of fake news (hoaxes). This led to a negative perception of the government among the public, which consequently influenced the opinions and political participation of Indonesian society. Therefore, a transformation is needed to support the formation of a positive government image. One of the strategies is maximizing government public relations. On August 8, 2023, the Communication Department at the Faculty of Social and Political Sciences, Universitas Airlangga, held a community service activity on the topic of government public relations training in Magetan Regency to address the political year. The main target of this activity was government officials in Bulukerto Subdistrict, Magetan District, Magetan Regency. The implementation mechanism consisted of three stages. In the initial stage, the community service team conducted surveys and coordinated with local government officials to gain a detailed understanding. During this stage, the Communication Department observed the involvement and performance of government public relations to obtain an initial overview of the strategies or designs used for the training. Subsequently, it was decided that the activity would be conducted through seminars and workshops covering topics such as public speaking, digital government, corporate social responsibility, and government public relations. After the activity, an evaluation was conducted to measure its success. It is hoped that this activity can serve as a foundation for improving the function of government public relations in addressing the political year and can be a supportive factor in ensuring the success of the 2024 elections.
Cathy Freeman: “one athlete, one nation, two flags” but a multi-dimensional message
Authors: Cruzin Valérie
Published: July 2024

El 25 de septiembre de 2000, Cathy Freeman ganó la final de los 400 metros en su país natal. Simbólica a dos niveles, político (Ory 2000, Nocita 2020) y social (Delporte 1991, White 2012) la imagen de esta victoria ocupó las portadas de los periódicos de todo el mundo.En efecto, el 25 de septiembre, Cathy Freeman decidió dar la vuelta de la victoria sosteniendo las dos banderas de su país -la australiana y la aborigen-, rompiendo así la regla número 50 de la Carta Olímpica. Estas dos banderas, unidas simbólicamente, mostraban al mundo su orgullo de ser aborigen y australiana. También sacaron a la luz al pueblo aborigen que había sido privado de sus derechos y tierras por el gobierno australiano desde que esta Terra Nulius fue conquistada en 1788 (Hugues 2003), en un contexto de reivindicaciones de reconciliación. Sin embargo, a pesar de algunas reacciones violentas (Hugues, 1987), el gesto de Freeman, preñado de reivindicaciones políticas e identitarias (White 2011), nunca fue castigado.¿Qué diferencias pueden establecerse entre este gesto político y el realizado treinta y dos años antes por Tommie Smith, John Carlos y Peter Norman, que fueron severamente sancionados? ¿Qué dice esta aparente clemencia sobre los Juegos Olímpicos?Al situar esta imagen en el contexto social e histórico de un país, Australia, y de un movimiento, el olimpismo, junto con un análisis semiótico de los titulares de los periódicos nacionales australianos (corpus), nos proponemos comprender mejor lo que muestra y revela sobre las cuestiones políticas y comunitarias en juego, así como las contradicciones que pone de manifiesto.
Autobiografia
Authors: Lubicz-Niezabitowski Edward
Published: July 2024

Pamiętnik Edwarda Niezabitowskiego (1863-1946), lekarza, profesora biologii Uniwersytetu Poznańskiego, ma charakter retrospektywny. Dostarcza wiedzy o życiu naukowym społeczeństwa polskiego w końcu XIX i w pierwszych dekadach XX w. Niezabitowski ukończył studia lekarskie w Krakowie. Poza medycyną interesował się biologią, paleontologią, zoologią, anatomią i botaniką. W pierwszych latach XX w. przez pewien czas pracował w stacji zoologicznej w Villefranche-sur- -Mer. Później był nauczycielem gimnazjalnym i lekarzem w Nowym Targu. Podczas I wojny światowej zorganizował szpital Czerwonego Krzyża w Nowym Targu, potem wyjechał do Mariboru, gdzie kierował austriackim szpitalem garnizonowym. Po wojnie objął Katedrę Anatomii i Histologii Zwierząt Domowych Wydziału Rolniczo-Leśnego Uniwersytetu Poznańskiego, a wkkrótce został dziekanem tego wydziału. W 1922 r. został profesorem biologii na Wydziale Lekarskim, a niebawem także dziekanem tego wydziału oraz rektorem Uniwersytetu Poznańskiego. Zmarł wkrótce po zakończeniu II wojny światowej
The September fate of the Field Hospital No. 702 of the 17th Infantry Division of the “Poznan” Army in the memoirs of a pharmacist and a physician
Authors: Waliszewski Stanisław
Published: July 2024

Przedstawione zostały dwa, uzupełniające się, wspomnienia uczestników kampanii wrześniowej 1939 r., farmaceuty Alfreda Reysnera, i lekarza Stanisława Waliszewskiego. Obaj służyli w Armii „Poznań”, w tym samym szpitalu polowym. Obaj wzięli udział w bitwie nad Bzurą, gdzie ich dywizja poniosła znaczne straty i praktycznie przestała istnieć jako zorganizowana jednostka. Charakterystyczną cechą obu wspomnień jest brak opisów działań medycznych i dominujący pesymizm oraz poczucie tragizmu.
J.M. Rektor UP, prof. dr Stefan Dąbrowski W służbie prawdy Apel do młodzieży w dniu inauguracji roku akademickiego 1945/1946
Authors: Magowska Anita
Published: July 2024

Opublikowano dokumenty wyjaśniające okoliczności, w których Wojewódzki Urząd Bezpieczeństwa Publicznego w Poznaniu doprowadził w 1946 r. do urlopowania prof. Stefana Dąbrowskiego (1877-1947) z funkcji rektora Uniwersytetu Poznańskiego. Główną przyczyną przerwania kadencji rektorskiej były jego endeckie poglądy i silne poparcie, jakiego prof. Dąbrowski udzielił zjazdowi młodzieży katolickiej zorganizowanemu w pomieszczeniach Uniwersytetu Poznańskiego. W opisywanym epizodzie życia S. Dąbrowskiego zaznaczają się cechy życia naukowego w Polsce okresu stalinowskiego. Po śmierci S. Dąbrowskiego, represje polityczne objęły jego rodzinę.
Kazimierz Hołoga (1913-1958) – wielkopolski chirurg
Authors: Bogusz Halina
Published: July 2024

Kazimierz Hołoga (1913-1958) ukończył konspiracyjne studia lekarskie w 1942 r. w Warszawie. Pracował jako chirurg w Szpitalu Elżbietanek w Poznaniu. Kiedy w okresie stalinowskim władze państwowe zlikwidowały ten szpital, Hołoga objął stanowisko dyrektora w szpitalu w Nowym Tomyślu. Był znany z wysokiego poziomu etycznego i uczciwości.
Stanisław Maeusel (1873-1919), a doctor and participant in the Wielkopolska Uprising
Authors: Pietrowicz Joanna
Published: July 2024

Stanisław Maeusel (1873-1919) studiował medycynę we Wrocławiu i Giessen. Po studiach zamieszkał w Ostrowie Wielkopolskim, gdzie wykonywał praktykę lekarską. Został powołany do wojska pruskiego po wybuchu I wojny światowej, później uczestniczył w powstaniu wielkopolskim. Po odzyskaniu przez Polskę niepodległości został naczelnym lekarzem Wielkopolskiego Okręgu Wojskowego. Zmarł jako ofiara zawodu, zarażony tyfusem od pacjenta
An epidemiological study on hepatitis C and hepatitis B infections among hemodialysis patients in the Sistan region
Authors: Shahramian I. ,   Zabol University of Medical Sciences, Zabol, Iran, Afshari M. , Tahani M. , Arefi M. , Jahanpanah A. ,   Zabol University of Medical Sciences, Zabol, Iran,   Zabol University of Medical Sciences, Zabol, Iran,   Zabol University of Medical Sciences, Zabol, Iran,   Zabol University of Medical Sciences, Zabol, Iran
Published: July 2024

Objective. Hepatitis is a systemic viral infection that mainly affects the liver. Transmission of hepatitis C virus through dialysis units is increasing worldwide, ranging from 5% in Western countries to 70% in some developing countries. The aim of this study was to evaluate the epidemiology of hepatitis C (HCV) and hepatitis B (HBV) infections among hemodialysis (HD) patients in the Sistan region. Patients and methods. In a descriptive cross-sectional study, 130 hemodialysis patients in the hemodialysis ward of the Sistan region were studied by census method. Sample information including name, sex, mortality rate, surgery, renal transplantation, underlying disease, and duration of dialysis was collected through a questionnaire. Blood samples were taken for hepatitis B antigen (HBsAg) and hepatitis C virus antibodies (Anti HCVAb) and analyzed by third-generation ELISA. Repeated positive ELISA test results of HCV, were evaluated by PCR test method. Results. Among 125 dialysis patients ranging from the age of 15 to 84 years, 15 patients (11/1%) were HBSAg positive, and 6 patients (4.4%) were HCVAb positive. All patients underwent dialysis for a minimum of two and a maximum of three sessions per week. In the year 2021, the mortality rate among dialysis patients was five. Сonclusion. The results of this study indicate the low prevalence and mortality rate of HBSAg and HCVAb among HD patients. However, the duration of dialysis can be a potential risk factor for the transmission of infectious viruses in dialysis centers. Key words: epidemiology, hemodialysis, HBV infection, HCV
Benedetto Croce. A Question of Method in the History of Philosophy
Authors: Rossius Julia ,   Institute of Philosophy, Russian Academy of Sciences
Published: July 2024

This publication presents a translation into Russian of Benedetto Croce’s essay from one of his later books “Philosophy and Historiography”. Here he raises the question of how the historian of philosophy should interpret those moments when the reasoning of a philosopher who is being studied is accidentally or deliberately not cleared up by him, or its development stops at a certain point. Considering the possible reasons for this, Croce touches on several themes to which his earlier writings were devoted and to which he returned throughout his scholarly life. Thus, he draws attention to the contradiction in the theory of knowledge of G. Vico, which consists in the application of the principle of verum-factum not only to history, but also to the mathematical sciences: on the one hand, only God can achieve truth in knowledge of nature, since he created nature, and on the other hand, truth in mathematics is available to man, since he “creates” mathematical elements and operations, and with them the method of natural science. Croce also points as an example to one of the contradictions in Hegel’s philosophy of nature, which consists in the confusion of empirical and speculative methods. It led to the endowment of the natural sciences with the status of “semi-philosophy”, to the untrue application of dialectics to the facts and concepts of the natural sciences. Convinced that the verum-factum formula can be combined with the teaching of absolute spiritualism, Croce warns against attributing such a connection to Vico himself, as this would mean incorporating later experience and a state of knowledge into his theory.
Philosophy of Historical Alternatives: “Uchronie” by Charles Renouvier
Authors: Krotov Artem ,   Lomonosov Moscow State University
Published: July 2024

The article analyzes the philosophy of the history of French neo-Kantianism school founder, the creator of the idea of Uchronia, Charles Renouvier. Attention is focused on the theoretical attitudes inherent in various stages of the creative development of Renouvier, and on their connection with «utopia in history». In his philosophy of history, Renouvier opposed the concept of predestination, the need for all events taking place. He insisted on the presence of freedom in history, on the possibility of moving along other paths of social reality, not fixed by tradition. In the alternative version of history depicted by the French thinker, Christianity triumphed not in the West, but in the East. The Crusades took place but were geographically directed in the opposite course. Progress in understanding of religion later returned Christianity to the West in a form cleared of fanaticism. Renouvier connected the future of human civilization with the republican social structure. He predicted the end of all kinds of wars. In a cautious, veiled form he criticized the Second Empire regime in France. Renouvier’s concept contained both strengths and weaknesses. It is fruitful in its call to focus in political life on the idea of the effectiveness of human free will, the idea of maximizing the moral content of the concept of the state. It is vulnerable in its intention to attach decisive importance to the intellectual factor in history.
A Two-Phase Flowback Type Curve with Fracture Damage Effects for Hydraulically Fractured Reservoirs
Authors: Zhang Fengyuan , Pan Yang , Liu Chuncheng , Yang Chia-Hsin , Emami-Meybodi Hamid , Rui Zhenhua
Published: July 2024

Type curves are a powerful tool in characterizing hydraulic fracture (HF) and reservoir properties based on flowback and production data. We propose a type-curve method to evaluate HF characteristics and their dynamics for multifractured horizontal wells (MFHWs) in hydrocarbon reservoirs using flowback production data. The type curve incorporates the HF damage effect of choked-fracture skin factor in the two-phase flow in HF and matrix domains. The type-curve method can be applied to inversely estimate choked-fracture skin factor, s, HF pore volume (PV), Vfi, and HF initial permeability, kfi, by analyzing two-phase flowback production data. By introducing the new dimensionless parameters, the nonuniqueness problem of the type-curve analysis for two-phase flow is significantly reduced by incorporating the complexity of fracture dynamics into one set of curves. The accuracy of the type curve is examined against the results obtained from numerical simulations of shale gas and oil reservoirs. The validation results demonstrate a good match of analytical type curves and numerical data plots and confirm the accuracy of the proposed method in estimating the static and dynamic fracture properties. The results show that the relative errors in Vfi, kfi, and s estimations are all <10% for the simulated cases that are presented in this work. The flexibility and robustness of the proposed method are illustrated using the field example from a shale oil MFHW. The accuracy and applicability of the proposed type curve are also validated by comparing the calculated fracture properties from the field example using straightline analysis with Vfi and kfi of 705.3 Mcf and 245.2 md, type-curve analysis method (without skin effect) with Vfi and kfi of 751.9 Mcf and 249.8 md, and the type-curve method (with the choked fracture skin considered) with Vfi and kfi of 708.7 Mcf and 252.9 md, which showed that the results of each case are very close to one another. The interpreted results from the flowback analysis of the field example offer quantitative insight into HF properties and dynamics.
Smartformer: An Intelligent Transformer Compression Framework for Time-Series Modeling
Authors: Wang Xiaojian , Wang Yinan , Yang Jin , Chen Ying
Published: July 2024

Transformer, as one of the cutting-edge deep neural networks (DNNs), has achieved outstanding performance in time-series data analysis. However, this model usually requires massive amounts of parameters to fit. Over-parameterization not only brings storage challenges in a resource-limited setting but also inevitably results in the model over-fitting. Even though literature works introduced several ways to reduce the parameter size of Transformers, none of them addressed this over-parameterized issue by concurrently achieving the following three objectives: preserving the model architecture, maintaining the model performance, and reducing the model complexity (number of parameters). In this study, we propose an intelligent model compression framework, Smartformer, by incorporating reinforcement learning and CP-decomposition techniques to satisfy the aforementioned three objectives. In the experiment, we apply Smartformer and five baseline methods to two existing time-series Transformer models for model compression. The results demonstrate that our proposed Smartformer is the only method that consistently generates the compressed model on various scenarios by satisfying the three objectives. In particular, the Smartformer can mitigate the overfitting issue and thus improve the accuracy of the existing time-series models in all scenarios.
Transcriptome-derived networks reconstruct distinct immune strategies under different iron availability between Arabidopsis and rice
Authors: Garcia-Molina Antoni , Martín-Cardoso Héctor , Ribaya María , Segundo Blanca San , Busoms Sílvia
Published: July 2024

Fe, an essential element for plants to sustain central biological functions, recently emerged as a modulator of immunity. However, our understanding of the crosstalk between Fe and defence is limited. Here, we report antagonistic immune phenotypes in Arabidopsis thaliana and Oryza sativa infected by Colletotrichum higginsianum and Magnaporthe oryzae under different Fe nutritional status. Functional and topological analysis of transcriptional networks unveiled interspecific differences in complexity and hierarchy for similar biological functions, as well as in Fe usage and distribution, to articulate defence. Mechanistically, our results are consistent with a regulatory role of Fe in the biosynthesis of the defensive metabolites glucosinolates in A. thaliana (joint effect hypothesis), whereas O. sativa uses Fe to trigger oxidative stress at infection sites (metal defence). Nevertheless, common regulatory features might differently coordinate the transcriptome responses of both species. An evolutionary interpretation of divergences in the interplay between Fe and immunity is discussed.
Validation of the interdisciplinary Norwegian vision assessment tool KROSS in stroke patients submitted to hospital or rehabilitation services
Authors: Falkenberg Helle K. , Langeggen Irene , Munthe-Kaas Ragnhild , Råen Marianne , Eilertsen Grethe , Mathisen Torgeir S.
Published: July 2024

Introduction Identifying vision problems after stroke is important for providing appropriate referral and vison rehabilitation in the healthcare services. In Norway, vision assessment is not standard routine or integrated in stroke care, due to lack of knowledge, guidelines and validated Norwegian assessment tools for healthcare professionals (HCP) without formal vision competence. This study aimed to validate and assess reliability of the KROSS vision assessment tool for identifying vision problems in stroke patients.
Methods The KROSS tool has 21 items, including symptoms, observations and assessment of visual acuity, visual field, eye movements and visual inattention. The primary outcome is to identify if a vision problem is present. Sixty-seven stroke survivors (69.8 years, 28 females)) was assessed twice. The first KROSS assessment was by an HCP without formal vision competence and compared to a reference assessment by an optometrist/KROSS specialist within two days. Sensitivity, specificity, positive and negative predictive values (PPV/NPV) and inter-rater reliability (Gwet’s AC1/Cohen’s Kappa) were calculated with 95% confidence intervals.
Results The KROSS tool demonstrated high sensitivity (98%) and specificity (83%), with excellent reliability (AC1 >0.86/Kappa >0.83) and observer agreement (93%) for the primary outcome. A vision problem was identified in 64%, where 44% reported a vision symptom. The PPV and NPV for identifying a vision problem were 0.91 and 0.95. Sensitivity scores for visual acuity, reading, and visual inattention assessments were all excellent (>80%) and specificity scores were high for all items (>70%). Most items showed excellent/substantial agreement (AC1>0.7/kappa>0.6). The lowest agreements were for motility (AC1>0.8/kappa>0.4) and peripheral visual fields (AC1>0.8/kappa>0.5).
Conclusions This study shows that the KROSS tool shows promises as a valuable tool for integrating vision assessment into stroke health services. It has high sensitivity and specificity, and excellent reliability, indicating high accuracy for identifying a vision problem. This indicates that KROSS tool can reliably be used by HCPs without formal vision competence to identify a vision problem. The fact that many stroke survivors were identified with vision problems using the KROSS tool, even if they did not complain of visual symptoms, support the significance of including structured vision assessment in stroke care.
Efficient Combinatorial Adaptor-Mediated Targeting of Acute Myeloid Leukemia with CAR T-Cells
Authors: Manz Markus , Volta Laura , Myburgh Renier , Pellegrino Christian , Koch Christian , Maurer Monique , Manfredi Francesco , Hofstetter Mara , Kaiser Anne , Schneiter Florin , Müller Jan , Buehler Marco , De Luca Roberto , Favalli Nicholas , Magnani Chiara , Schroeder Timm , Neri Dario
Published: July 2024

CAR T-cell products targeting lineage-specific cell-of-origin antigens, thereby eliminating both tumor and healthy counterpart cells, are currently clinically approved therapeutics in B- and plasma-cell malignancies. While they represent a major clinical improvement, they are still limited in terms of efficacy by e.g. single, sometimes low-expressed antigen targeting, and in terms of safety by e.g. lack of on-off activity. Successful cell-of-origin non-discriminative targeting of heterogeneous hematopoietic stem and progenitor cell malignancies, such as acute myeloid leukemia (AML), will require antigen-versatile targeting and off-switching of effectors in order to then allow rescue by hematopoietic stem cell transplantation (HSCT), preventing permanent myeloablation. To address this, we developed adaptor-CAR (AdFITC-CAR) T-cells targeting fluoresceinated AML antigen-binding diabody adaptors. This platform enables the use of adaptors matching the AML-antigen-expression profile and conditional activity modulation. Combining adaptors significantly improved lysis of AML cells in vitro. In therapeutic xenogeneic mouse models, AdFITC-CAR T-cells co-administered with single diabody adaptors were as efficient as direct CAR T-cells, and combinatorial use of adaptors further enhanced therapeutic efficacy against both, cell lines and primary AML. Collectively, this study provides proof-of-concept that AdFITC-CAR T-cells and combinations of adaptors can efficiently enhance immune-targeting of AML.
Do you get what you pay for? The influence of emotional valence and scarcity on the price-quality effect
Authors: Zhao Na , Sun Yixin , Shi Minyang , Chen Yuxin
Published: July 2024

The impact of emotions on price-quality perceptions is not well understood. We conducted for studies to explore this relationship. The results showed that positive mood had a positive impact on the price-quality effect, while negative mood did not significantly affect the relationship (Study 1). In addition, participants primed with a positive mood relied more on price when making quality judgments than those primed with a negative mood (Studies2 and 3). We also found that the sense of scarcity moderated the relationship between emotional valence and the price-quality effect (Study 4). Specifically, positive and negative moods had different impacts on the price-quality effect only among participants with a lower sense of scarcity. These findings advance our understanding of price-quality judgments and shed light on how the sense of scarcity influences the relationship between mood and the price-quality effect.