bluuebunny/crossref_metadata_2025 huggingface dataset:
Corrosion behaviors of the UNS N10003 alloy in Fenton's reagent
Authors: Zhou Yuying , Yin Huiqin , Wang Xueliang , Cao Mingpeng , Yang Xu , Wu Yanping , Wu Boheng , Yan Long
Published: January 2020

The corrosion behavior of the UNS N10003 alloy in Fenton's reagent was investigated at room temperature for 600 hr by the static immersion method. The results showed that the alloy suffered obvious pitting corrosion. The lattice parameter of this alloy has a slight decrease after corrosion. This is mainly attributed to the depletion of Mo‐rich carbides dissolving into solution caused by the hydroxyl radical with strong oxidization, which is very different from the result of the UNS N10003 alloy under the molten salt condition. The results provide an insight into the corrosion of the alloy under hydroxyl radical conditions (i.e., Fenton's reagent), and will offer a realistic instruction in related fields.
Electrical Properties of Magnetoactive Boron‐Organo‐Silicon Oxide Polymers
Authors: Monkman Gareth J. , Striegl Birgit , Prem Nina , Sindersberger Dirk
Published: January 2020

The electrical properties of rheopectic magnetoactive composites comprising boron‐organo‐silicon oxide dielectric matrices containing carbonyl iron microparticles are presented for the first time. The increase in interfacial magnetocapacitance is seen to greatly exceed that experienced when using conventional elastomeric matrices such as polydimethylsiloxane. In addition to the increase in capacitance, a simultaneous and sharp decrease in the parallel electrical resistance over several orders of magnitude is also observed. The effects are time dependent but repeatable. Potential applications include magnetically controlled frequency dependent devices, magnetic sensor systems, weighting elements for neural networks, etc.
Seeking attention versus seeking approval: How conspicuous consumption differs between grandiose and vulnerable narcissists
Authors: Neave Lydia , Tzemou Effy , Fastoso Fernando
Published: January 2020

Narcissism, a personality trait characterized by entitlement and conceit, is increasingly prevalent in society. Two subtypes of narcissism exist: grandiose narcissism (characterized by arrogance and dominance) and vulnerable narcissism (characterized by social insecurity and overreliance on others’ feedback). We posit that both narcissistic subtypes will engage in ostentatious, showy purchases, that is, conspicuous consumption. Since the two subtypes differ so profoundly in their self‐esteem regulation strategies, we further posit that their motivations to consume conspicuously may vary. Specifically, we hypothesize that grandiose narcissists’ conspicuous consumption will be driven by their need‐for‐uniqueness, whilst that of vulnerable narcissists by their need to avoid social disapproval. We test our hypotheses using data obtained from 382 participants. Our results support our expectations that both narcissism subtypes predict conspicuous consumption and that the relationship between grandiose narcissism and conspicuous consumption is mediated by their need‐for‐uniqueness. Meanwhile, we find that approval‐seeking (AS) is only a marginally significant mediator of vulnerable narcissism and conspicuous consumption in females. We discuss theoretical and managerial implications.
Genomic integration of unclonable gene expression cassettes in Saccharomyces cerevisiae using rapid cloning‐free workflows
Authors: Cataldo Vicente F. , Salgado Valeria , Saa Pedro A. , Agosin Eduardo
Published: January 2020

Most DNA assembly methods require bacterial amplification steps, which restrict its application to genes that can be cloned in the bacterial host without significant toxic effects. However, genes that cannot be cloned in bacteria do not necessarily exert toxic effects on the final host. In order to tackle this issue, we adapted two DNA assembly workflows for rapid, cloning‐free construction and genomic integration of expression cassettes in Saccharomyces cerevisiae. One method is based on a modified Gibson assembly, while the other relies on a direct assembly and integration of linear PCR products by yeast homologous recombination. The methods require few simple experimental steps, and their performance was evaluated for the assembly and integration of unclonable zeaxanthin epoxidase expression cassettes in yeast. Results showed that up to 95% integration efficiency can be reached with minimal experimental effort. The presented workflows can be employed as rapid gene integration tools for yeast, especially tailored for integrating unclonable genes.
Exosomes secreted by prostate cancer cells under hypoxia promote matrix metalloproteinases activity at pre‐metastatic niches
Authors: Deep Gagan , Jain Anil , Kumar Ashish , Agarwal Chapla , Kim Susy , Leevy W. Matthew , Agarwal Rajesh
Published: January 2020

Approximately, 30 000 men die from prostate cancer (PCa) every year in the United States, mainly due to the metastasis. Thus, the key events associated with PCa metastasis are under rigorous investigation, with recent studies showing that preparation of pre‐metastatic niches (PMN) in distant organs is an important step. However, the molecular basis for PMN preparation is still unclear. Hypoxia in primary tumors promotes aggressiveness; however, its precise role in metastasis is not clear. We recently reported that exosomes secreted by PCa cells under hypoxia promote stemness and invasiveness in naïve PCa cells; however, whether these extracellular vesicles also influence PMN remains unknown. In the present study, we isolated exosomes from human PCa PC3 cells under normoxic (21% O2, exosomes secreted under normoxic condition [ExoNormoxic]) and hypoxic (1% O2, exosomes secreted under hypoxic condition [ExoHypoxic]) conditions, and characterized their effect (10 µg exosomes, intraperitoneal (IP) treatment every 48 hours for 4 weeks) on key biomarkers associated with PMN in nude mice. Whole animal fluorescence imaging showed that ExoHypoxic treatment promotes matrix metalloproteinases (MMPs) activity in several putative metastatic sites. Histological studies confirmed that ExoHypoxic treatment enhanced the level of MMP2, MMP9, and extracellular matrix proteins (fibronectin and collagen) as well as increased the number of CD11b+ cells at selective PMN sites. Furthermore, proteomic profiling of exosomes by liquid chromatography/mass spectrometry identified cargo proteins in ExoNormoxic and ExoHypoxic as well as distinct canonical pathways targeted by them. These results suggest that exosomes secreted by PCa cells under hypoxia plausibly remodel distant PMN, and thus, could be a potential target to control metastatic PCa.
Proteomic Atomics Reveals a Distinctive Uracil‐5‐Methyltransferase
Authors: Pramanik Subrata , Thaker Manisha , Perumal Ananda Gopu , Ekambaram Rajasekaran , Poondla Naresh , Schmidt Markus , Kim Pok‐Son , Kutzner Arne , Heese Klaus
Published: January 2020

Carbon (C), hydrogen (H), nitrogen (N), oxygen (O), and sulfur (S) atoms intrigue as they are the foundation for amino acid (AA) composition and the folding and functions of proteins and thus define and control the survival of a cell, the smallest unit of life. Here, we calculated the proteomic atom distribution in >1500 randomly selected species across the entire current phylogenetic tree and identified uracil‐5‐methyltransferase (U5MTase) of the protozoan parasite Plasmodium falciparum (Pf, strain Pf3D7), with a distinct atom and AA distribution pattern. We determined its apicoplast location and in silico 3D protein structure to refocus attention exclusively on U5MTase with tremendous potential for therapeutic intervention in malaria. Around 300 million clinical cases of malaria occur each year in tropical and subtropical regions of the world, resulting in over one million deaths annually, placing malaria among the most serious infectious diseases. Genomic and proteomic research of the clades of parasites containing Pf is progressing slowly and the functions of most of the ∼5300 genes are still unknown. We applied a ‘bottom‐up’ comparative proteomic atomics analysis across the phylogenetic tree to visualize a protein molecule on its actual basis – i. e., its atomic level. We identified a protruding Pf3D7‐specific U5MTase, determined its 3D protein structure, and identified potential inhibitory drug molecules through in silico drug screening that might serve as possible remedies for the treatment of malaria. Besides, this atomic‐based proteome map provides a unique approach for the identification of parasite‐specific proteins that could be considered as novel therapeutic targets.
Measurement of the hydrodynamic radii of PEE‐G dendrons by diffusion spectroscopy on a benchtop NMR spectrometer
Authors: McCarney Evan R. , Breaux Carol J. , Rendle Phillip M.
Published: January 2020

Benchtop nuclear magnetic resonance (NMR) spectroscopy is a useful tool for the rapid determination of the self‐diffusion coefficient and the hydrodynamic radius of dendrons. The self‐diffusion coefficients of the first four generations of poly ethoxy ethyl glycinamide (PEE‐G) dendrons are measured by diffusion‐ordered spectroscopy (DOSY) on a benchtop NMR equipped with diffusion gradient coils. The hydrodynamic radii of the dendrons are calculated via the Stokes–Einstein equation. The effects of solvent and pH are determined with the hydrodynamic radius increasing with generation and decreasing upon neutralization of an acidic solution. These measurements provide valuable information for biological and pharmaceutical applications of dendrons.
A method for extending a general constitutive model to consider the electro‐chemo‐mechanical phenomena of mineral crystals in expansive soils
Authors: Kyokawa Hiroyuki , Ohno Shintaro , Kobayashi Ichizou
Published: January 2020

The mechanical behavior of expansive soils varies according to the chemical composition of the pore fluid. It is well known that electrochemical phenomena on the surface of clay mineral crystals considerably affect their macrostructural behavior. In particular, a change in the pore fluid composition causes osmotic consolidation or swelling. In this study, a model is constructed to describe the characteristic behavior of expansive soils by coupling the interlaminar behavior of clay mineral crystals and the soil skeleton behavior. The interlaminar behavior is derived from the electro‐chemo‐mechanical coupling equilibrium of mineral crystals, and the soil skeleton behavior is given by a general elastoplastic constitutive model for soils. This modeling approach extends a general model to consider the electro‐chemo‐mechanical phenomena of mineral crystals. Oedometer tests with the replacement of the cell fluid and the swelling pressure and deformation tests on expansive clays are simulated with the proposed model. The simulation results indicate that the proposed method can reasonably represent the typical behavior of expansive soils.
Consensus document on the multidisciplinary management of neurogenic lower urinary tract dysfunction in patients with multiple sclerosis
Authors: Medina‐Polo José , Adot José María , Allué Marta , Arlandis Salvador , Blasco Pedro , Casanova Bonaventura , Matías‐Guiu Jorge , Madurga Blanca , Meza‐Murillo Edwin‐Roger , Müller‐Arteaga Carlos , Rodríguez‐Acevedo Breogán , Vara Jesús , Zubiaur María Carmen , López‐Fando Luis
Published: January 2020

Aim

Neurogenic lower urinary tract dysfunction (NLUTD) is very common in multiple sclerosis (MS) patients. Early diagnosis and treatment are crucial to avoid irreversible damage and improve quality of life. Our aim was to develop recommendations to improve NLUTD identification in MS patients, along with their referral and management.

Methods

A multidisciplinary group of 14 experts in the management of patients with MS and NLUTD (nine urologists, three neurologists, and two rehabilitators) was selected. A comprehensive review of the literature was undertaken and a set of recommendations was generated and submitted to a Delphi panel of 114 experts. Recommendations were presented according to the grade of agreement (GA).

Results

Early diagnosis in asymptomatic patients with risk factors for complications is recommended (GA 94%). Postvoid residual volume should be measured if changes in urinary symptoms (GA 87%), preferably ultrasound‐guided (GA 86%). Early referral to urologist is recommended if urinary incontinence (GA 91%), significant post‐void residual volume (94%), quality of life impairment (GA 98%) and recurrent urinary infections (GA 97%). The initial evaluation should include physical examination (GA 99%) and urodynamics including cystometry (GA 89%), pressure‐flow study (90%) and electromyography (GA 70%). The panel recommends multidisciplinary collaboration (GA 100%) with a rehabilitation specialist and trained nurses in the management of NLUTD (GA 99%).

Conclusions

Multidisciplinary management for patients with NLUTD due to MS is advised, including urologists, neurologists, rehabilitation, and nurses. Panel recommends early diagnosis with post‐void residual volume in symptomatic patients before referring to urologist and urodynamics when referred.
Case of pulp stones and dental wear in a Mesolithic (5900 ± 100 BC) individual from Woźna Wieś (Poland)
Authors: Tomczyk Jacek , Myszka Anna , Regulski Piotr , Olczak‐Kowalczyk Dorota
Published: January 2020

The present study will focus on the analysis of pulp stones and dental wear of an adult (26–30 years old) individual from Woźna Wieś, dated from the Mesolithic period (5900 ± 100 BC). The dental material included 14 permanent teeth. Cone beam computed tomography was used in the identification of pulp stones. Pulp stones were classified by location and volume. The scores for mechanical dental wear were based on the scales proposed by Smith and Scott.

The anterior teeth showed an advanced stage of mechanical dental wear. The first molars exhibit higher wear scores than the second and third molars. The pulp stones were diagnosed in 10 teeth (10/14, 71%). Generally, these calcified structures were found in the pulp chamber (10/14, 71%). The relationship between the stages of dental wear and the presence of pulp stones turned out to be statistically significant (p = .012). The correlation coefficients between tooth wear and pulp stones in the pulp chambers and root canals were .434 and .327, respectively. The pulp stones occur most frequently on the teeth with advanced dental wear. However, we also cannot rule out the dietary factor. It can be supposed that this individual's diet did not lack products with high calcium content.
Benefits of Home‐Based Respiratory Muscle Training from the Perspectives of Individuals Who Had a Stroke: Qualitative Study
Authors: de Menezes Kênia Kiefer Parreiras , Nascimento Lucas Rodrigues , Avelino Patrick Roberto , Teixeira‐Salmela Luci Fuscaldi
Published: January 2020

Background

Although the significance of respiratory muscle training has been established in the literature, there is a need to understand the participantsʼ perceptions of the benefits of this intervention.

Objective

To understand how individuals who had a stroke perceive changes in their body functions and structures, activities, and participation after a high‐intensity respiratory muscle training intervention and to understand their perceptions of the benefits and limitations of a home‐based intervention.

Design

Qualitative study.

Setting

Community‐dwelling patients.

Patients

Fifteen individuals who had a stroke.

Methods

For this qualitative study, interviews were conducted using a semistructured questionnaire about topics related to participation in a home‐based respiratory muscle training intervention. The interviews were transcribed and analyzed using thematic content analysis.

Results

Fifteen participants were interviewed. Most of the participants reported positive perceptions of body functions and structures, grouped into two thematic categories (breathing and speech); activity, also grouped into two thematic categories (walking and domestic activities); and participation, grouped into one thematic category (community‐leisure activities). Answers about the benefits of a home‐based intervention were grouped into three thematic categories (no need to leave home, commitment to training, and comfort). All participants reported that they would recommend the intervention to other stroke patients and that they were either satisfied or very satisfied with the intervention. Most (80%) participants did not consider the intervention difficult to perform.

Conclusion

Individuals who had experienced a stroke perceived the benefits of high‐intensity home‐based respiratory muscle training in all components of function.
They just don't take their medicines: Reframing medication adherence in asthma from frustration to opportunity
Authors: De Keyser Heather Hoch , Ramsey Rachelle , Federico Monica J.
Published: January 2020

Assessing and addressing suboptimal adherence to asthma medications is a key component in the treatment of all children with asthma, particularly those with difficult‐to‐treat asthma. However, parents often overreport adherence to asthma medications. Increased medication adherence could lead to improved outcomes in the form of better asthma control and decreased asthma exacerbations, as well as decreased healthcare utilization costs. Yet there are many complex factors that affect medication adherence, and barriers are often different in each family. Social determinants of health, complex healthcare relationships, and patient‐related factors may all affect medication adherence. Multicomponent patient‐centered strategies, as well as strategies that utilize technology and habit formation strategies may be helpful in improving medication adherence. Further study is needed to reliably and sustainably improve medication adherence in children with asthma across the broader population; in some populations, alternate diagnoses, adjusting therapy, and other intervention may be required to improve asthma control and health.
Bringing semantics to multicloud service compositions
Authors: Ghazouani Souad , Mezni Haithem , Slimani Yahya
Published: January 2020

Over the last decade, cloud computing has emerged as a new paradigm for delivering various on‐demand virtualized resources as services. Cloud services have inherited not only the major characteristics of web services but also their classical issues, in particular, the interoperability issues and the heterogeneous nature of their hosting environments. This latter problem must be taken into account when composing various cloud services, in order to answer users' complex requirements. Moreover, leading cloud providers started to offer their services across multiple clouds. This adds a new factor of heterogeneity, as composition engines must take into consideration the heterogeneity not only at the service level (eg, service descriptions) but also at the cloud level (eg, pricing models, security policies). In this context, the semantics of multicloud actors must be incorporated into the multicloud service composition (MCSC) process. However, most existing approaches have treated the semantic service composition in traditional single‐cloud environments. The few works in multicloud settings have ignored the semantics of cloud zones and resources. Moreover, they often focus on the general aspect of MCSC (eg, horizontal or vertical compositions). Even the few researchers who have addressed both vertical and horizontal service compositions, conducted their research studies in the context of single‐ cloud environments, which were proven to be unrealistic and offer limited quality of service (QoS) and security support. To ensure a high interoperability when composing services from multiple heterogeneous clouds and to enable a horizontal/vertical semantic service compositions, we take advantage of a standardized and semantically enriched generic service description, including all aspects (technical, operational, business, semantic, contextual) and supporting different cloud service models (SaaS, PaaS, IaaS, etc). We also incorporate Semantic Web Rule Language into the MCSC process to enable not only rule‐based reasoning about various composition constraints (eg, QoS constraints, cloud zones constraints) but also to provide accurate semantic matching of cloud services' capabilities. Conducted experiments have proven the ability of our approach to combine high‐quality services from the optimal number of clouds.
Solvent accessibility limitation by plant matrix compounds in extraction of rutin from Solanum lycopersicum
Authors: Lück Manuel , Bergs Frederik , Jupke Andreas
Published: January 2020

Extraction procedures for plant‐based secondary metabolites are mainly influenced by choice of solvent, particle size and solvent to feed ratio. For developing an extraction protocol design‐of‐experiments or model‐based approaches have widely been used. Botanical aspects such as the influence of side compounds are less investigated. Either for analytical or preparative purposes, knowledge of the underlying extraction mechanisms is required to improve the process development. In this work, we demonstrate the mechanism of accessibility limitation of rutin by side compounds depending on the solvent to feed ratio. Extraction yields of target and side compounds are analyzed to derive correlations. The role of side compounds as limiting factors for target compound accessibility is demonstrated by performing two extraction steps using three different plant species. The maximum extraction yield of rutin is reached using a solvent to feed ratio of at least 300 for all three investigated plant species, while side compounds in liquid state generally affect the extractability of rutin. Phosphatidylcholines are identified as possible accessibility‐limiting compounds. In conclusion, the yields of target and side compounds strongly depend on the solvent to feed ratio, while side compounds cover the target compound in dry matter, reducing its accessibility.
Improving the wind‐induced human comfort of the Beijing Olympic Tower by a double‐stage pendulum tuned mass damper
Authors: Chen Xin , Li Aiqun , Zhang Zhiqiang , Hu Liang , Sun Peng , Fan Zhong , Liu Xianming
Published: January 2020

With five sub towers and a maximum height of 246.8 m, the Beijing Olympic Tower (BOT) is a landmark of Beijing. The complex structural properties and slenderness of the BOT render it prone to wind loading. As far as the wind‐induced performance of this structure is concerned, this paper thus aims at a tuned mass damper‐based mitigation system for controlling the wind‐induced acceleration response of the BOT. To this end, the three‐dimensional wind loading of various wind directions are simulated based on the fluctuating wind force obtained by the wind tunnel test, by which the wind‐induced vibration is evaluated in the time domain by using the finite element model. A double‐stage pendulum tuned mass damper (DPTMD), which is capable of controlling the long period dynamic response and requires only a limited space of installation, is optimally designed at the upper part of the tower. Finally, the wind‐induced response of the structure with and without DPTMD is compared with respect to various wind directions and in both the time and frequency domains. The comparative results show that the wind‐induced accelerations atop the tower with the wind directions of 45, 135, 225, and 315° are larger than those with the other directions. The DPTMD significantly reduces the wind‐induced response by the maximum acceleration reduction ratio of 30.05%. Moreover, it is revealed that the control effect varies noticeably for the five sub towers, depending on the connection rigidity between Tower1 and each sub tower.
Impact of different forest densities on atmospheric boundary‐layer development and wind‐turbine wake
Authors: Adedipe Taiwo A. , Chaudhari Ashvinkumar , Kauranne Tuomo
Published: January 2020

The aim of this work is to investigate the atmospheric boundary‐layer (ABL) flow and the wind turbine wake over forests with varying leaf area densities (LAD). The forest LAD profile used in this study is based on a real forest site, Ryningsnäs, located in Sweden. The reference turbine used to model the wake is a well‐documented 5‐MW turbine, which is implemented in the simulations using an actuator line model (ALM). All simulations are carried out with openFOAM using the Reynolds averaged Navier‐Stokes (RANS) approach. Twelve forest cases with leaf area index (LAI) ranging from 0.42 to 8.5 are considered. Results show that the mean velocity decreases with increasing LAI within the forest canopy, but increases with LAI above the hub height. Meanwhile, the turbulent kinetic energy (TKE) varies nonmonotonically with forest density. The TKE increases with forest density and reaches to its maximum at an average LAI of 1.70, afterwards, it decreases gradually as the density increases. It is also observed that the forest density has a clear role in the wake development and recovery. Comparisons between no‐forest and forest cases show that the forest characteristics help in damping the added turbulence from the turbine. As a consequence, the forest with the highest upstream turbulence has the shortest wake downstream of the turbine.
Disturbance observer‐based integral sliding mode control for wind energy conversion systems
Authors: Suleimenov Kanat , Sarsembayev Bayandy , Duc Hong Phuc Bui , Do Ton Duc
Published: January 2020

Recently, wind power production has been under the focus in generating power and became one of the main sources of alternative energy. Generating of maximum power from wind energy conversion system (WECS) requires accurate estimation of aerodynamic torque and uncertainties presented in the system. The current paper proposed the generalized high‐order disturbance observer (GHODO) with integral sliding mode control (ISMC) for extraction of maximum power via variable speed wind turbine by accurate estimation of wind speed. The assumption in previous works that considers the aerodynamic torque as slow‐varying is not applicable for the real system. Therefore, the high‐order disturbance observers were designed for precise estimation of uncertainties with fast‐changing behavior. A robust control system was designed to control the speed of the rotor at the optimal speed ratio. The obtained simulation results have shown the better performance characteristics than conventional linear quadratic regulator (LQR) approach. The stability of the proposed algorithm was proven by Lyapunov stability anaysis. Simulations results were obtained in Matlab/Simulink environment.
Investigations on Tetragonally Distorted Sodium Thallide NaTl‐tI8
Authors: Tiefenthaler Susanne M. , Schlosser Marc , Pielnhofer Florian , Shenderovich Ilya G. , Pfitzner Arno , Gärtner Stefanie
Published: January 2020

In‐depth investigations of the long‐time known Zintl phase NaTl revealed a phase transition of tetragonal NaTl‐tI8 [I41/amd; a = 5.2268(9) Å, c = 7.539(1) Å, V = 205.97(9) Å3] to Zintl's cubic NaTl‐cF16 [Fd3m; a = 7.4697(6) Å, V = 416.79(5) Å3] between 351 and 355 K. This phase transformation was observed for NaTl prepared by two different synthetic routes including Zintl's original procedure. An excess of sodium applied during the synthesis in liquid ammonia also resulted in the formation of NaTl‐tI8. DSC measurements suggest a first order phase transition. In addition to in‐situ temperature dependent powder X‐ray diffraction experiments, DSC measurements and solid‐state NMR investigations, we also performed theoretical DOS and band structure calculations for the cubic and tetragonal phase, respectively. The results suggest Na‐Tl interactions in the second coordination sphere being responsible for the observed tetragonal distortion of Zintl's cubic NaTl.
An alternative to diagrams for the critical O(N) model: dimensions and structure constants to order 1/N2
Authors: Alday Luis F. , Henriksson Johan , van Loon Mark
Published: January 2020

Abstract

We apply the methods of modern analytic bootstrap to the critical O(N) model in a 1/N expansion. At infinite N the model possesses higher spin symmetry which is weakly broken as we turn on 1/N. By studying consistency conditions for the correlator of four fundamental fields we derive the CFT-data for all the (broken) currents to order 1/N, and the CFT-data for the non-singlet currents to order 1/N2. To order 1/N our results are in perfect agreement with those in the literature. To order 1/N2 we reproduce known results for anomalous dimensions and obtain a variety of new results for structure constants, including the global symmetry central charge CJ to this order.
The holographic dual of the entanglement wedge symplectic form
Authors: Kirklin Josh
Published: January 2020

Abstract

In this paper, we find the boundary dual of the symplectic form for the bulk fields in any entanglement wedge. The key ingredient is Uhlmann holonomy, which is a notion of parallel transport of purifications of density matrices based on a maximisation of transition probabilities. Using a replica trick, we compute this holonomy for curves of reduced states in boundary subregions of holographic QFTs at large N, subject to changes of operator insertions on the boundary. It is shown that the Berry phase along Uhlmann parallel paths may be written as the integral of an abelian connection whose curvature is the symplectic form of the entanglement wedge. This generalises previous work on holographic Berry curvature.
Leading multi-stress tensors and conformal bootstrap
Authors: Karlsson Robin , Kulaxizi Manuela , Parnachev Andrei , Tadić Petar
Published: January 2020

Near lightcone correlators are dominated by operators with the lowest twist. We consider the contributions of such leading lowest twist multi-stress tensor operators to a heavy-heavy-light-light correlator in a CFT of any even dimensionality with a large central charge. An infinite number of such operators contribute, but their sum is described by a simple ansatz. We show that the coefficients in this ansatz can be determined recursively, thereby providing an operational procedure to compute them. This is achieved by bootstrapping the corresponding near lightcone correlator: conformal data for any minimal­ twist determines that for the higher minimal-twist and so on. To illustrate this procedure in four spacetime dimensions we determine the contributions of double- and triple-stress tensors. We compute the OPE coefficients; whenever results are available in the literature, we observe complete agreement. We also compute the contributions of double-stress tensors in six spacetime dimensions and determine the corresponding OPE coefficients. In all cases the results are consistent with the exponentiation of the near lightcone correlator. This is similar to the situation in two spacetime dimensions for the Virasoro vacuum block.
Peak Ground Motions and Site Response at Anza and Imperial Valley, California
Authors: Fletcher Jon B. , Boatwright John
Published: January 2020

Power spectra of shear-waves for eighteen earthquakes from the Anza-Imperial Valley region were inverted for source, mid-path Q, site attenuation and site response. The motivation was whether differences in site attenuation (parameterized ast*, r/cQ,whereris distance along ray path near the site,cis shear velocity andQis the quality factor that parameterizes attenuation) and site response could be correlated with residuals in peak values of velocity or acceleration after removing the affect of distance-dependent attenuation. We decomposed spectra of S-waves from horizontal components of 18 earthquakes from 2010 to 2018 into a common source for each event with ω−2spectral fall-off at high frequencies and then projected the residuals onto path and site terms following the methodology of Boatwright et al. (Bull Seismol Soc Am 81:1754–1782, 1991). The site terms were constrained to have an amplification at a particular frequency governed by VS30at two of the sites which had downhole shear-wave logs. The 18 events, 3 < M < 4, had moments between approximately 1020and 1022 dyne-cm, and stress drops between 1 and 100 bars. Average mid-crust attenuation had a Q of 844 reflecting the average path through the crystalline rock of the San Jacinto Mountains.t*for each station corresponded to the geologic environment such that stations on hard rock had lowt*(e.g. stations KNW, PFO and RDM) a station in the San Jacinto fault zone (station SND) had a moderatet*of 0.035 s and stations in the Imperial Valley usually had highert*s. Generallyt*correlated with average amplification suggesting that sites characterized by low surface velocities and higher attenuation also have more amplification in the 1–6 Hz band. Residuals of peak values were determined by subtracting the prediction of Boore and Atkinson (2008). There is a correlation between average amplification and peak velocity, but not peak acceleration. Interestingly, there is less scatter at high values of amplification although there is also less data. Scatter in values of peak velocity and peak acceleration are higher at shorter compared to longer durations. When using a frequency-dependent form forQ, variances are higher, sometimes much higher; the dataset does not support frequency-dependentQ, which is not similar to results from the Imperial Valley and northeastern North America.
Correction to: Multiple model synchronizationwith multiary delta lenses with amendment andK-Putput
Authors: Diskin Zinovy , König Harald , Lawford Mark
Published: January 2020

Owing to a production error, the reference in footnote
Real-time atmospheric extinction variation analysis with the Photometric Telescope at Xinglong Observatory
Authors: Zhao Yong , Fan Zhou , Ge Liang , Ren Juanjuan , Tian Jianfeng , Wang Jianfeng , Qiu Peng , Jiang Xiaojun
Published: January 2020

We present the Photometric Auxiliary System (PAS) attached to the 25-cm Photometric Telescope (PT) at Xinglong Observatory of National Astronomical Observatories, Chinese Academy of Sciences (NAOC). This PAS can provide real-time atmospheric extinction for other telescopes at the same station for flux calibration via observing standard stars, e.g. the 2.16-m reflector and 1-m telescope. Moreover, the real-time atmospheric extinction could act as a useful reference for other local telescopes regarding the adjustment of observing strategies, such as changing the exposure time, which is important for the observers. This PAS has been operated since February 2012, and we have obtained the $r$r-band atmospheric extinction of Xinglong Observatory from February 2012 to March 2018. With these data, we have analyzed the atmospheric extinction of Xinglong Observatory in detail.
Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study
Authors: von Stemann Jakob H. , Pedersen Ole B. , Hjalgrim Henrik , Erikstrup Christian , Ullum Henrik , Thørner Lise W. , Larsen Margit AH. , Burgdorf Kristoffer S. , Sørensen Erik , Hansen Morten B. , Ostrowski Sisse R.
Published: January 2020

The presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected pathologies. However, the overall influence of c-aAb on immunocompetence remains largely unknown. In this paper, we performed a large-scale investigation of c-aAb association with infection risk. A cohort of healthy Danish blood donors was screened for c-aAb against IL-1α, IL-6, IL-10, IFNα, and GM-CSF using a Luminex-based multiplex assay, and results were linked to data from the Danish National Prescription Registry. The filing of an antimicrobial prescription following c-aAb measurement was used as a proxy for impaired immunocompetence. We found that c-aAb against pro-inflammatory cytokines IFNα and GM-CSF tended to associate with increased risk of prescription filings in women, whereas antibodies against anti-inflammatory IL-10 were associated with a lower predicted risk of antimicrobial prescriptions, as well as higher self-perceived health scores. We also observed an association of cumulative c-aAb presence with prescription risk. Our data show that cytokine autoantibodies in healthy individuals associate with various proxies for immunomodulation, with the exact association dependent on the pattern of pro- or anti-inflammatory cytokines targeted. This suggests that c-aAb may express cytokine-modulatory properties in healthy individuals and may be critical to further investigate as biomarkers of immunodeficiency.
Mental Health in the UK Police Force: a Qualitative Investigation into the Stigma with Mental Illness
Authors: Edwards Ann-Marie , Kotera Yasuhiro
Published: January 2020

Police work is a high-risk profession that can cause mental health conditions. With increasing sickness levels and falling police numbers, it is essential prompt mental health treatment be implemented. The study aims to explore institutional negativity and stigma in the police force towards mental ill health. Semi-structured interviews attended by five police officers with thematic analysis captured (i) police culture, (ii) the stigma of mental illness, (iii) disclosure of mental illness and (iv) breaking down barriers. Findings indicate police culture and attitudes to mental health may contribute to the causes of psychological illness, rather than the nature of the job itself. Increased education and awareness surrounding mental health have been shown to be fundamental in how an officer reacts to stress, but change is needed at a managerial level. Future research needs to explore the effects of mental health stigma on ethnicity and gender in the police force.
Type of cancer treatment and cognitive symptoms in working cancer survivors: an 18-month follow-up study
Authors: Ehrenstein Johanna K. , van Zon Sander K.R. , Duijts Saskia F.A. , van Dijk Boukje A.C. , Dorland Heleen F. , Schagen Sanne B. , Bültmann Ute
Published: January 2020

Purpose

Cognitive symptoms are reported to affect cancer survivors’ functioning at work. However, little is known about the type of cancer treatment and cognitive symptoms in working cancer survivors. We examined the longitudinal association between type of cancer treatment and cognitive symptoms in cancer survivors post return to work, and whether the course of cognitive symptoms over 18 months differed per type of cancer treatment.

Methods

Data from the Dutch longitudinal “Work-Life after Cancer” study were used. The study population consisted of 330 working cancer survivors who completed questionnaires at baseline, and 6, 12, and 18 months follow-up. Cognitive symptoms were assessed with the cognitive symptom checklist-work and linked with cancer treatment data from the Netherlands Cancer Registry. Data were analyzed using generalized estimating equations.

Results

Cancer survivors who received chemotherapy reported comparable memory symptom levels (b: − 2.3; 95% CI = − 7.1, 2.5) to those receiving locoregional treatment. Executive function symptom levels (b: − 4.1; 95% CI = − 7.8, − 0.4) were significantly lower for cancer survivors who received chemotherapy, compared with those receiving locoregional treatment. In cancer survivors who received other systemic therapy, memory (b: 0.4; 95% CI = 0.1, 0.7) and executive function symptom levels (b: 0.4; 95% CI = 0.0, 0.7) increased over time. In cancer survivors who received chemotherapy and locoregional treatment, memory and executive function symptom scores were persistent during the first 18 months after return to work.

Conclusions

The contradictory finding that cancer patients receiving chemotherapy report fewer cognitive symptoms warrants further research.

Implications for Cancer Survivors

Working cancer survivors may have cognitive symptom management needs irrespective of the type of cancer treatment they received.
Complete remission of disseminated Langerhans cell sarcoma after stem cell transplantation
Authors: Schlintl Verena , Schlick Konstantin , Russ Gudrun , Gampenrieder Simon Peter , Monzo Fuentes Claudia , Kos Tea , Renneberg Felix , Rettenbacher Lukas , Gradl Johann , Sotlar Karl , Hoffmann Alexander , Greil Richard
Published: January 2020

With fewer than 100 cases described in the English literature so far, Langerhans cell sarcoma represents an orphan malignant disease deriving from histiocytic cells. Clinical course is extremely aggressive and associated with poor survival rates, especially in disseminated condition. Herein, we describe the case of a young patient with fulminant development of metastatic Langerhans cell sarcoma, who achieved persistent remission after polychemotherapy and subsequent high-dose chemotherapy with autologous stem cell transplantation.
Evaluation of NDVI Estimation Considering Atmospheric and BRDF Correction through Himawari-8/AHI
Authors: Seong Noh-Hun , Jung Daeseong , Kim Jinsoo , Han Kyung-Soo
Published: January 2020

Satellite-based vegetation indices are an essential element in understanding the Earth’s surface. In this study, we estimated the normalized difference vegetation index (NDVI) using Himawari-8/Advanced Himawari Imager (AHI) data and analyzed the sensitivity of products to atmospheric and surface correction. We used the Second Simulation of a Satellite Signal in the Solar Spectrum (6S) radiative transfer model for atmospheric correction, and kernel-based semi-empirical bidirectional reflectance distribution function (BRDF) model to remove surface anisotropic effects. From this, top-of-atmosphere, top-of-canopy, and normalized NDVIs were produced. A sensitivity analysis showed that the normalized NDVI had the lowest number of missing values compared with the others and almost no low peaks during the study period. These results were validated by Terra and Aqua/Moderate Resolution Imaging Spectroradiometer (MODIS) and Project for On-Board Autonomy/Vegetation (PROBA) NDVI product, showing the root mean square error (RMSE) and bias of 0.09 and + 0.04 (MODIS) and 0.09 and − 0.04 (PROBA), respectively. These results also satisfied the FP7 Geoland2/BioPar project-defined user requirements (threshold: 0.15; target: 0.10).
The limits of replicability
Authors: Guttinger Stephan
Published: January 2020

Discussions about a replicability crisis in science have been driven by the normative claim that all of science should be replicable and the empirical claim that most of it isn’t. Recently, such crisis talk has been challenged by a new localism, which argues a) that serious problems with replicability are not a general occurrence in science and b) that replicability itself should not be treated as a universal standard. The goal of this article is to introduce this emerging strand of the debate and to discuss some of its implications and limitations. I will in particular highlight the issue of demarcation that localist accounts have to address, i.e. the question of how we can distinguish replicable science from disciplines where replicability does not apply.
Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B
Authors: Grover Anita , Crippen-Harmon Danielle , Nave Lacey , Vincelette Jon , Wait Jill C. M. , Melton Andrew C. , Lawrence Roger , Brown Jillian R. , Webster Katherine A. , Yip Bryan K. , Baridon Brian , Vitelli Catherine , Rigney Sara , Christianson Terri M. , Tiger Pascale M. N. , Lo Melanie J. , Holtzinger John , Shaywitz Adam J. , Crawford Brett E. , Fitzpatrick Paul A. , LeBowitz Jonathan H. , Bullens Sherry , Aoyagi-Scharber Mika , Bunting Stuart , O’Neill Charles A. , Pinkstaff Jason , Bagri Anil
Published: January 2020

BMN 250 is being developed as enzyme replacement therapy for Sanfilippo type B, a primarily neurological rare disease, in which patients have deficient lysosomal alpha-N-acetylglucosaminidase (NAGLU) enzyme activity. BMN 250 is taken up in target cells by the cation-independent mannose 6-phosphate receptor (CI-MPR, insulin-like growth factor 2 receptor), which then facilitates transit to the lysosome. BMN 250 is dosed directly into the central nervous system via the intracerebroventricular (ICV) route, and the objective of this work was to compare systemic intravenous (IV) and ICV delivery of BMN 250 to confirm the value of ICV dosing. We first assess the ability of enzyme to cross a potentially compromised blood–brain barrier in the Naglu−/− mouse model and then assess the potential for CI-MPR to be employed for receptor-mediated transport across the blood–brain barrier. In wild-type and Naglu−/− mice, CI-MPR expression in brain vasculature is high during the neonatal period but virtually absent by adolescence. In contrast, CI-MPR remains expressed through adolescence in non-affected non-human primate and human brain vasculature. Combined results from IV administration of BMN 250 in Naglu−/− mice and IV and ICV administration in healthy juvenile non-human primates suggest a limitation to therapeutic benefit from IV administration because enzyme distribution is restricted to brain vascular endothelial cells: enzyme does not reach target neuronal cells following IV administration, and pharmacological response following IV administration is likely restricted to clearance of substrate in endothelial cells. In contrast, ICV administration enables central nervous system enzyme replacement with biodistribution to target cells.
Correction to: Food Vendor Beware! On Ordinary Morality and Unhealthy Marketing
Authors: Tempels Tjidde , Blok Vincent , Verweij Marcel
Published: January 2020

The title of the article in the initial online publication was mixed up with copy editing information. The original article has been corrected.
Would you like to shop via mobile app technology? The technology acceptance model, social factors and purchase intention
Authors: Vahdat Arash , Alizadeh Ali , Quach Sara , Hamelin Nicolas
Published: January 2020

This study investigates how technology acceptance model (TAM) factors and social factors determine customer purchase intention. Although previous studies on mobile apps have investigated TAM, critical social factors have been neglected, thus, reinforcing the need to study the latter’s contribution to consumer purchase intention. Accordingly, this study examines social influence and peer influence in the TAM and collects 777 questionnaires from Digikala app users. Data were then analysed using structural equation modelling by AMOS. The findings indicate that perceived usefulness does not have a significant effect on attitude towards mobile app use. However, perceived ease of use, social and peer influence, and intention to purchase were shown to exhibit positive effects on attitude in this regard. The results also demonstrate that attitude towards mobile app use is a full mediator on three paths of the model. Finally, moderation analysis showed that only age has a mediating effect on the path from perceived usefulness to attitude towards mobile app use.