bluuebunny/crossref_metadata_2025 huggingface dataset:
sobrerrepresentación de los estudiantes pertenecientes a minorías culturales y lingüísticas en itinerarios de educación especial: una revisión de la literatura en Europa
Authors: Chieppa Maria Antonietta , Sandoval Marta
Published: January 2022

El texto se propone revisar la literatura europea publicada entre 2000 y 2020, sobre la cuestión de la sobrerrepresentación de los alumnos de minorías culturales y lingüísticas (MCL) que son diagnosticados y etiquetados por las administraciones educativas como alumnos con discapacidad, o con Necesidades Educativas Especiales (NEE). Las búsquedas, que se realizaron en las bases de datos ERIC, SCOPUS y Web of Science, se centraron en los enfoques teóricos y metodológicos de estos estudios. Los artículos analizados se han categorizado en cuatro tipos de aportaciones según el enfoque temático: a) la organización escolar y el rendimiento académico de los estudiantes; b) los sesgos profesionales; c) los procedimientos de diagnóstico y etiquetado; y d) la relación entre las desigualdades estructurales y la sobrerrepresentación. Una de las principales conclusiones de este estudio indica que, a pesar de que en muchos casos se ha adoptado una perspectiva uniaxial como clave para comprender el fenómeno, con una atención enfocada en factores individuales como el prejuicio de profesionales, el rendimiento escolar, la naturaleza de las pruebas de diagnóstico, en los últimos años se está produciendo un cambio en la forma en que la investigación sobre la sobrerrepresentación está abordando el tema.
Inovação em tecnologias submarinas na exploração oceânica: passado e presente
Authors: Corrêa Fernanda das Graças
Published: January 2022

O objetivo neste texto é analisar, ao longo da história, inovações em tecnologias submarinas desde as invenções de Leonardo Da Vinci aos dias de hoje e a multiplicidade de seus empregos na exploração da última fronteira: o mar.
Formação do conflito palestino-israelense
Authors: Caitano Sérgio Nunes
Published: January 2022

Este trabalho busca estudar como se deu o surgimento do atual conflito palestino-isralense, as origens, e para tanto, utiliza registros cartográficos. Busca compreender como no jogo de poder anterior, na constância, e após a Primeira Guerra Mundial, se deu a delimitação do espaço geográfico na Palestina e a legitimação do povo judeu e palestino social e politicamente. A razão para a escolha do tema é a ideia de que, sem se estudar os fundamentos, as memórias, que levaram ambos os povos a se legitimarem como senhores daquele espaço geográfico, não há entendimento, nem solução para o impasse.
Ensino e inclusão acadêmica
Authors: Silva Sandoval Alves da , Siqueira João Renato Rodrigues , Silva Dhennifer Nunes da
Published: January 2022

O presente artigo é fruto de uma pesquisa sobre a educação superior e as práticas de ensino dos professores realizada em uma turma de Direito Processual Civil do curso de Direito da Universidade Federal do Pará, no âmbito do programa de iniciação à docência denominado monitoria. Essa pesquisa tem como objetivo geral demonstrar a necessidade, ainda nos dias de hoje, de vencer a chamada “educação bancária”, por meio da aplicação da educação libertadora iniciada por Paulo Freire e complementada por José Carlos Libâneo. Ao longo do artigo, mostra-se que é necessário modificar a metodologia da narração, da transferência e da padronização do conhecimento adotada pelo professor em sala de aula, levando-o a olhar para os alunos com uma atenção maior e a tomar ciência de que o seu papel não se limita a transferir o conhecimento, sendo mais importante motivar a construção do conhecimento, para que os alunos deixem de ser meros receptores sem voz e tornem-se integrantes do processo de ensino. O método de pesquisa foi exploratório, explicativo, descritivo e qualitativo. A aplicação direta em sala de aula das obras Pedagogia do oprimido e Pedagogia da indignação, de Paulo Freire, e da obra Didática, de José Carlos Libâneo, teve como resultados positivos a motivação, o rendimento educacional e a criação de consciências próprias nos alunos. Confirma-se, na conclusão, que ainda hoje há a necessidade de substituição da metodologia bancária utilizada pelo docente em sala de aula.
O conceito de cidade internacional aplicado à Jerusalém: questões históricas e correntes
Authors: S. Cantuária Christian Leonardo , Cardoso Squeff Tatiana
Published: January 2022

Como parte do Plano da Organização das Nações Unidas para Partilha da Palestina, Jerusalém se tornou uma cidade internacional em 1947, sendo eventualmente anexada por israelenses. A iniciativa de Trump, em seu primeiro ano de governo, de mudar a embaixada dos Estados Unidos em Israel, de Tel Aviv para Jerusalém, não apenas agravou o conflito árabe-israelense que se mantém desde o Plano da ONU, como também deu início a uma disputa acerca da legalidade da decisão à luz do Direito Internacional, inclusive, diante da Corte Internacional de Justiça, especialmente, em função do statusde Jerusalém. Nesse passo, visando apontar a ilegalidade nas ações de Trump e seus impactos na condição de corpus separatum de Jerusalém é que se desenvolve a presente pesquisa. Entende-se que, por meio da Convenção de Viena sobre Relações Diplomáticas, a transferência estadunidense então almejada é ilegal visto que Jerusalém não pertence oficialmente a algum Estado. Apesar disso, consoante o histórico da região, nota-se que o direito internacional e suas instituições mostram-se enquanto verdadeiras ferramentas de dominação dos países centrais, como os EUA, incentivando a adoção de medidas semelhantes por Estados periféricos. Portanto, a partir deste estudo, conclui-se que não apenas o governo Trump agiu de forma ilegal, como contribuiu para desestabilizar as frágeis relações entre Israel e Palestina. Ademais, que mesmo após a sua saída, a situação permanece inalterada pelo que se observa do governo de Joe Biden, porquanto as políticas segregacionistas do governo israelense contra palestinos persistem sendo apoiadas, sendo possível afirmar que Trump deixa como legado a impossibilidade de um processo de paz benéfico para ambas as partes no Oriente Médio.
Social big data, sociología y ciencias sociales computacionales
Authors: Gualda Estrella
Published: January 2022

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Entrevista a Guillermo Rendueles Olmedo, psiquiatra
Authors: Terrón Bañuelos Aida
Published: January 2022

Al hilo de la biografía profesional del psiquiatra Guillermo Rendueles, se hace un recorrido por la España de las últimas décadas del siglo pasado y las primeras del actual. Se tratan asuntos como la  situación de la formación universitaria, la conflictividad política, las luchas por un nuevo sistema de formación de los médicos residentes, el movimiento por la reforma del manicomio y la deriva de la Salud Mental en la España democrática.
De los cursos de puericultura a la educación maternal: el papel de las matronas en la preparación para el nacimiento en España a lo largo del siglo XX
Authors: Ruiz Berdún Dolores
Published: January 2022

Uno de los factores que se ha considerado históricamente más im¬portantes para luchar contra la mortalidad infantil ha sido la educación de las madres. Entre las estrategias utilizadas para mejorarla se encuentra la educación grupal, que hoy es una competencia casi exclusiva de las ma¬tronas. Pero no siempre fue así. Este artículo está centrado en el análisis del papel de estas profesionales en la educación de las embarazadas en España, que comenzó con los cursos para madres ofertados por la Escue¬la Nacional de Puericultura. En 1955 empezaron a popularizarse los cur¬sos para embarazadas destinados a difundir los métodos para el control del dolor en el parto. Los dos primeros libros publicados en España sobre el tema vieron la luz de la mano de una matrona y un médico respectiva¬mente, formados en el extranjero en dichas técnicas. Inicialmente fueron los médicos los más interesados en la difusión, entre las embarazadas, de estas técnicas del control del dolor, llegando a crearse unidades específicas en las grandes residencias sanitarias del tardofranquismo. Algunos ayun-tamientos también incorporaron la «preparación al parto» en su cartera de servicios. Pero la auténtica generalización de la educación maternal llegó de la mano de la incorporación de las matronas a los Centros de Atención Primaria de Salud a finales de los años ochenta.
LUIS MIGUEL LÁZARO LORENTE. La «Nueva Atenas» del Mediterráneo. Vicente Blasco Ibáñez, cultura y educación populares en Valencia (1890-1931)
Authors: Davila Balsera Pauli
Published: January 2022

Reseña
El compromiso ideológico y político en la crítica cinematográfica de Silvia Mistral
Authors: Barrera Velasco Patricia
Published: January 2022

En este artículo se aborda la dedicación de Silvia Mistral a la crítica cinematográfica, ámbito en el que destacó dentro del ejercicio de su labor periodística, en revistas como Popular Film, Films Selectos, Proyector o Nuevo Cinema —de la que fue también secretaria—, donde fue responsable de numerosas crónicas cinematográficas y reportajes sobre el mundo del celuloide y sus protagonistas. La figura de esta escritora ha sido merecedora de la atención de los críticos, que se han centrado fundamentalmente en las obras que publicó en el exilio, en México, pero falta todavía destacar su papel como pionera de la crítica de cine. Este trabajo pone una primera piedra en este sentido y contribuye a dar valor a un autora polifacética y comprometida política y socialmente.
MITOLOGÍA Y CIENCIA FICCIÓN: EL CASO DE MYTHS OF THE NEAR FUTURE DE JAMES G. BALLARD
Authors: VARO ZAFRA Juan
Published: January 2022

La relación entre mitología y ciencia ficción es paradójica: si, teóricamente, la ciencia ficción se presenta como opuesta del mito; en su producción narrativa recurre frecuentemente a personajes y esquemas míticos, materializando su dimensión prospectiva a través de la actualización evemerista o alegórica de mitos. Este trabajo revisa críticamente los presupuestos teóricos que escinden la literatura de ciencia ficción de los relatos míticos y la literatura fantástica. A continuación, analizaremos el modo en que James G. Ballard afronta esta cuestión en su narrativa breve, particularmente en Myths of the Near Future, que sobrepasa estas diferencias y plantea un nuevo marco teórico común entre literatura fantástica y mítica y la ciencia ficción.
Abstract: The relationship between mythology and science fiction is paradoxical: if, theoretically, science fiction is presented as the opposite of myth; in its narrative production, science fiction frequently resorts to mythical characters and schemes, materializing their prospective dimension through the evemerist or allegorical updating of myths. This work critically reviews the theoretical assumptions that divide science fiction literature from mythical stories and fantasy fiction. Next, it analyzes the way in which James G. Ballard addresses this question in his short narrative, particularly in Myths of the Near Future, which goes beyond these differences and raises a new common theoretical framework between fantasy and mythical literature and science fiction.
EL DISCURSO SUBVERSIVO DE PATRICIA ESTEBAN ERLÉS EN EL CONTEXTO DE LO FANTÁSTICO FEMINISTA
Authors: ÁLVAREZ MÉNDEZ Natalia
Published: January 2022

La poética fantástica de Patricia Esteban Erlés (Zaragoza, 1972) constituye una contestación al ideario conservador asumido por nuestro imaginario cultural. Así lo demuestran características relativas a la selección y el tratamiento de los personajes, la temática, la construcción y la significación del espacio narrativo, el modo de abordar la monstruosidad derivada de la realidad sexista, las propuestas formales y la apuesta por el hibridismo genérico. Su análisis estará imbricado con reflexiones sobre la consolidación de esta línea de lo fantástico feminista en las últimas décadas en el ámbito de la narrativa en español y sobre la posible existencia de un canon de autoras, tanto en español como en otras lenguas, que haya podido influir en esa fragua de lo fantástico escrito por mujeres con una clara perspectiva política, en la que lo no mimético se convierte en una herramienta ideológica de denuncia social y genérica. 
Abstract: Born Zaragoza, 1972, Patricia Esteban Erlés’s poetics of fantastic represents a contestation to the conservative ideology assumed by our cultural imaginary. This is demonstrated by some characteristics related to the selection and treatment of characters, the subject, the construction and the signification of the narrative space, the approach to monstrosity as derived from sexist reality, the formal proposals and the inclination towards generic hybridism. Its analysis will be interweaved with reflections on the consolidation of this trend of the feminist fantastic in the last decades in the Spanish narrative panorama and the possible existence of a female writers canon, both in Spanish and other languages, that could have influenced the forging of the fantastic written by women with a clear political perspective in which non-mimetic genres have become an ideological tool for gender and social denunciation.
Los hermanos Moreno Galván
Authors: Pérez Castillo María Regina
Published: January 2022

Los hermanos Moreno Galván suponen uno de los ejemplos más sólidos de compromiso político y estético durante el franquismo. Mientras Francisco Moreno Galván componía letras flamencas que criticaban, de un modo metafórico y soterrado, la falta de libertades e injusticias sociales que se vivían en España, su hermano José María elaboraba una teoría del arte en la que sostenía que el flamenco es una construcción popular, vinculada al concepto unamuniano de “intrahistoria”, y que, al igual que otras manifestaciones plásticas, experimenta una renovación estética. Las Reuniones de Cante Jondo de La Puebla de Cazalla (Sevilla), de las que Francisco es padre, acabarían convirtiéndose en mítines políticos “cantados” o interpretados que encontrarían eco en la teoría estética y el periodismo de su hermano José María.
La creatividad en el proceso formativo del profesorado. Acercamiento a las experiencias creadoras en el profesorado novel de música
Authors: Arriaga Crisitna , De Alba Eguiluz Baikune , Ibarmia Urruzola Gorka
Published: January 2022

El desarrollo de la creatividad es una de las principales premisas de la educación musical. Sin embargo, el profesorado de música, formado frecuentemente dentro de una educación tradicional, encuentra dificultades para llevar a cabo propuestas creativas en el aula de música. El objetivo principal de este estudio es identificar los factores implicados en el desarrollo de las competencias relacionadas con la creatividad en la formación inicial del profesorado de educación primaria. Para ello se ha recogido la experiencia de un docente novel de música a través de una entrevista en profundidad, y se ha analizado la información obtenida aplicando la técnica del análisis de contenido. Los resultados reflejan la importancia de reforzar los aspectos creativos en la formación musical y en la formación inicial del profesorado de música, ofreciendo a los futuros docentes espacios donde poner en práctica y con confianza propuestas creativas que contribuyan a su enriquecimiento personal y a fomentar su autonomía.
Editorial 31
Authors: Vernia Carrasco Ana Mercedes
Published: January 2022

Tras una nueva ley educativa y la cercana re- forma o propuesta de ley de enseñanzas artís- ticas, la educación vuelve a ser centro de aten- ción y reivindicaciones por parte de diferentes ámbitos y sectores. En este sentir, la educación musical, la educación artística, la educación humanística, vuelve a relegarse a puestos se- cundarios, a pesar de que numerosas investi- gaciones ponen en valor y muestran evidencias de la importancia de las artes en la construc- ción del ser humano. ARTSEDUCA, recoge en su núm. 31 investigaciones relacionadas con la calidad educativa, la formación docente y discente, así como experiencias didácticas, sin descuidar la atención especial a los Objetivos de Desarrollo Sostenible (ODS).
Reconstruction of large facial defects using a combination of forehead flap and other procedures
Authors: Kim Ryuck Seong , Yi Changryul , Kim Hoon Soo , Jeong Ho Yoon , Bae Yong Chan
Published: January 2022

Background: Reconstruction of large facial defects is challenging as both functional and cosmetic results must be considered. Reconstruction with forehead flaps on the face is advantageous; nonetheless, reconstruction of large defects with forehead flaps alone results in extensive scarring on the donor site. In our study, the results of reconstruction using a combination of forehead flaps and other techniques for large facial defects were evaluated.Methods: A total of 63 patients underwent reconstructive surgery using forehead flaps between February 2005 and June 2020 at our institution. Reconstruction of a large defect with forehead flaps alone has limitations; because of this, 22 patients underwent a combination of procedures and were selected as the subjects of this study. This study was retrospectively conducted by reviewing the patients’ medical records. Additional procedures included orbicularis oculi musculocutaneous (OOMC) V-Y advancement flap, cheek advancement flap, nasolabial V-Y advancement flap, grafting, and simultaneous application of two different techniques. Flap survival, complications, and recurrence of skin cancer were analyzed. Patient satisfaction was evaluated using questionnaires.Results: Along with reconstructive surgery using forehead flaps, nasolabial V-Y advancement flap was performed in nine patients, local advancement flap in three, OOMC V-Y advancement flap in two, grafting in five, and two different techniques in three patients. No patient developed flap loss; however, cancer recurred in two patients. The overall patient satisfaction was high.Conclusion: Reconstruction with a combination of forehead flaps and other techniques for large facial defects can be considered as both functionally and cosmetically reliable.
Chansons madécasses, modernisme et érotisme
Authors: Lazzaro Federico
Published: January 2022

L’utilisation passe-partout du concept d’exotisme pour décrire la musique se référant directement à un « autre » géographique est particulièrement problématique dans le cas de Maurice Ravel. Étant donné la présence prépondérante de l’« autre » dans sa musique (qu’il s’agisse d’un autre géographique, chronologique ou stylistique), il est indispensable de différencier cas par cas l’attitude et les choix compositionnels du compositeur. En suivant notamment les réflexions de Ralph P. Locke au sujet de l’exotisme musical et en s’interrogeant sur la perception des topoï musicaux, cet article propose une lecture des Chansons madécasses qui va au-delà de leur exotisme. Nous analysons les choix de Ravel par rapport aux textes et soulignons la portée moderniste et expressive (notamment érotique) davantage qu’« exotique » de ses choix musicaux.
Quels liens établir entre la philosophie praxialiste de David Elliott et le programme de formation de niveau primaire du Ministère de l’Éducation au Québec (PFEQ) dans le domaine de la musique ?
Authors: Daigle Véronique
Published: January 2022

En 1995, David J. Elliott publie Music Matters. A New Philosophy of Music Education. À travers cet ouvrage, l’auteur propose une nouvelle philosophie de l’éducation musicale appelée praxialisme. Cet essai vise à mettre en exergue les liens pouvant être établis entre la philosophie praxialiste d’Elliott et le programme de formation de niveau primaire du Ministère de l’éducation au Québec (PFEQ) dans le domaine de la musique. Cet essai présente les fondements et lignes directrices du praxialisme, notamment en relation avec l’élaboration de programmes de formation. Il s’attache également, afin d’obtenir un portrait éclairé de cette philosophie, aux pour et contre reliés au praxialisme. Enfin, cet essai décrit les points essentiels du PFEQ et met en lumière les différents liens qui peuvent être établis entre la philosophie praxialiste et le PFEQ.
HUMAN RIGHTS AND MIGRATIONS IN THE AMERICAS: REVISITING THE DORZEMA ET AL VS DOMINICAN REPUBLIC CASE
Authors: Duhaime Bernard , Lafontaine Catherine
Published: January 2022

This article first reviews the principles developed by the Inter-American institutions regarding the human rights of migrants. It also discusses the historical and socio-economic phenomenon of discrimination that prevails in the Dominican Republic against Haitians or Dominicans of Haitian origin, and in which the Case Nadège Dorzema took place. The text then discusses the strategy and legal arguments submitted to the Inter-American Commission and the Court of Human Rights by the victims' representatives to demonstrate how the State violated the former’s right to equality. Finally, the authors analyse the Court's findings on these issues and address the difficulties anticipated regarding the implementation of the judgment.
Le leadership conscient au profit d’un engagement individuel et collectif bienveillant
Authors: Mercier Sylvie , Vallières Annie
Published: January 2022

Les multiples changements, le rythme et les exigences liées au travail sont de grands défis actuels pour les gestionnaires et les employés de diverses organisations. Pour aider les gestionnaires à naviguer à travers les défis qu’ils doivent relever, le développement d’habiletés liées au leadership conscient est une voie prometteuse vers de nouvelles pratiques managériales[26]. La pleine conscience, traduction française de Mindfulness, signifie faire attention d’une manière particulière, délibérément, au moment présent et sans jugements de valeur[1,8]. À cet égard, le leader conscient est davantage ancré dans le moment présent et il crée un environnement et un climat de confiance par la qualité de présence et d’écoute, la capacité à prendre du recul et la justesse dans la prise de décision[2,10]. Ce type de leadership se développe en s’offrant des moments de recul et d’arrêt au cours desquels on apprivoise la tranquillité et le silence afin de pouvoir faire le vide et prendre une saine distance avec notre environnement[3]. Par conséquent, le gestionnaire est en mesure d’observer concrètement ce qui se passe, percevoir clairement les enjeux de l’instant présent pour avoir une perspective plus claire. De plus, ce leadership est bénéfique pour l’organisation, car il engendre un sentiment de sécurité et de confiance propice à un engagement individuel et collectif, de même qu’à une performance accrue[1]. On dira du leader conscient qu’il est un leader humaniste, bienveillant, qui use d’un leadership transformationnel, qui fait preuve d’authenticité et qui sait être au service de son équipe et de son organisation et qui soutient une performance durable[2,5,11].
Tentative d’épuisement d’un flux parisien
Authors: David Sylvain , Marcotte Sophie
Published: January 2022

Le roman Écoute (2018) de Boris Razon a pour sujet le téléphone intelligent. Il met en scène, sous prétexte d’une surveillance policière, les flux de données émis par une foule de passants anonymes à Paris. Ce texte est présenté par son auteur comme une reprise fictionnelle de Tentative d’épuisement d’un lieu parisien (1975) de Georges Perec. L’écart entre les deux versions permet de réfléchir aux enjeux soulevés par la représentation romanesque d’Internet et des réseaux socionumériques.
L’histoire de la philosophie et le discours indirect
Authors: Panaccio Claude
Published: January 2022

L’examen des conditions d’adéquation du discours indirect est nécessaire à la compréhension du travail historique en philosophie, la notion centrale ici étant celle d’« équivalence sémantique ». On montre, à partir de là, pourquoi une pluralité de reformulations bien différentes est en principe admissible pour une même doctrine selon le contexte et les intérêts de l’historien.
Applaudissements, remerciements, moyens de bien faire leur travail, qu’attendent les agents hospitaliers comme signes de reconnaissance ?
Authors: Baret Christophe , Kornig Cathel , Recotillet Isabelle
Published: January 2022

La reconnaissance au travail est un des facteurs essentiels de la qualité de vie au travail. Alors que la littérature a mis en évidence la dégradation des conditions de travail à l’hôpital cet article a pour objectif d’étudier les relations entre les conditions de travail et la perception des pratiques de reconnaissance au travail. Nous adoptons l’approche de la reconnaissance en 4 dimensions (existentielle, de la pratique de travail, de l’investissement au travail et des résultats du travail) définie par Brun et Dugas (2005) pour identifier les dimensions qui sont les plus impactées par la transformation des conditions de travail. Nous avons interrogé en entretiens semi-directifs 16 personnels tirés au sort et 5 experts dans un centre hospitalier universitaire français au cours de l’année 2018. Les résultats montrent que la plupart des catégories de personnel regrettent le manque de moyens matériels et humains mis à disposition par la direction pour réaliser un travail de qualité. Ce manque de moyens est perçu comme un manque de reconnaissance de la qualité du travail de la part de la direction de l’établissement. En raison du manque d’effectif, de nombreux personnels accroissent leur investissement pour malgré tout produire des soins de qualité au patient, ils regrettent alors une non reconnaissance de leur investissement au travail. Seules les catégories de personnel les moins qualifiées expriment des attentes de reconnaissance existentielle.
Le dialogue social : un puissant outil régulateur du processus de RSE des entreprises : étude de trois cas en Tunisie
Authors: Bouderbala Amel
Published: January 2022

L’objectif de cette étude qui a eu lieu dans le contexte tunisien est de comprendre le rôle que peuvent jouer le syndicat et le comité d’entreprise dans le processus de responsabilité sociale de l’entreprise (RSE). La position épistémologique adoptée est interprétativiste et la méthodologie est qualitative, moyennant l’étude de trois cas d’entreprises. Pour mener à bien cette recherche compréhensive, trois outils de collecte de données ont été utilisés : les notes d’observation, les entretiens semi-directifs et les rapports de RSE de l’entreprise.

Les principaux résultats montrent comment, d’un cas à l’autre, les types de RSE, les motifs d’engagement de RSE et les types de régulations diffèrent. La règle qui est inhérente au mode pratique et de pilotage de la RSE conditionne le type de régulation. Les résultats permettent de conclure que, dans tous les cas de figure, le syndicat et le comité d’entreprise constituent une partie prenante primordiale en matière de RSE par leur capacité mobilisatrice et divers types de régulation qui renforcent ou affaiblissent le processus de RSE. Le dialogue social en ressort comme un puissant levier pour légitimer et développer les pratiques de RSE dans une action collective co-construite. Il agit comme un outil de RSE à la fois robuste et pragmatique qui régule ce processus et qui réifie les aspirations des acteurs autour de ce construit (RSE).
Dermoscopy of pilomatricoma: A case report with a review of the literature
Authors: Chakiri Radia , Bouhajeb Youssef
Published: January 2022

Pilomatricoma is a benign tumor originating from hair follicle matrix cells and characterized by the presence of cutaneous and subcutaneous nodules up to 3.0 cm in diameter, usually on the head, neck, and upper extremities, rarely on the trunk and lower extremities. An eleven-year-old female with a painless, erythematous-purplish tumor of the back. A dermoscopic examination revealed irregular linear vessels, white structures, and structureless grayish-blue areas. Histological examination after excision confirmed the diagnosis of pilomatricoma. Dermoscopy may be a useful tool for improving the clinical recognition of pilomatricoma.
A relapse of pemphigus vulgaris in pemphigus herpetiformis or a phenotypic “switch”
Authors: Belmourida Siham , Meziane Meriame , Ismaili Nadia , Benzekri Laila , Hassam Badreddine , Senouci Karima
Published: January 2022

Sir, Pemphigus herpetiformis (PH) was originally described by Jablonska et al. in 1975. Clinically, PH presents itself as a herpetiform dermatitis with immunopathological characteristics of pemphigus [1,2]. We report an exceptional case of typical pemphigus vulgaris (PV) relapsing after 36 years in PH. A 65-year-old patient, followed for PV for 36 years and treated with corticosteroid therapy with a remission for more than thirty years, consulted for pruriginous lesions evolving for the previous eight months. A dermatological examination revealed urticariform pruriginous ring lesions surmounted by small peripheral vesicles spread throughout the body (Fig. 1), sparing the mucous membranes, and without Nikolsky’s sign. After two non-specific skin biopsies, the histological examination revealed an intraepidermal bubble with acantholytic cells and eosinophilic spongiosis (Figs. 2a and 2b). Direct immunofluorescence confirmed the diagnosis of pemphigus and indirect immunofluorescence was at the upper limit. The diagnosis of a PV relapse in PH was retained and a dapsone-based treatment was initiated at a dose of 150 mg/day and stopped seven days later when met with hemolytic anemia. Oral corticosteroid therapy involving prednisone at a dose of 1 mg/kg/day was initiated but, given the persistence of the pruritus, the decision was to combine methotrexate at a dose of 12.5 mg/week. A good evolution and a decline within eight months were observed. An improved pruritus and the disappearance of the skin lesions were achieved after one month of treatment. PV and PH are two different anatomical and clinical entities of the autoimmune disease pemphigus, with distinct clinical, histopathological, and immunopathological characteristics [1,2]. Our observation documents a complete phenotypic “switch” of pemphigus with a transition from PV to PH both clinically, histologically, and immunologically. Several rare cases of PV switching to superficial pemphigus (SP) (“phenotypic switch”) have, since 1991, been reported, with a higher frequency this direction than otherwise; the transition period varies from six months to twenty years [3]. To the best of our knowledge, no case has been described of a progression from PV to PH. Having observed one firsthand, we are first to describe the case of a complete phenotypic switch from PV to PH. The mechanism of such a transition remains poorly understood and is often observed during a relapse. Some authors suggest that the effect of immunosuppressants on the desmoglein DSG3 more marked than on DSG1 could explain the relapse of PS in PH [3,4]. Future studies on the immunological factors and predictors of PV relapses after the discontinuation of treatment would be useful to better understand the mechanisms of a relapse in pemphigus, with or without a phenotypic transition.
CD8+ mycosis fungoides: A wolf in sheep’s clothing?
Authors: Abdelmouttalib Asmae , Sialiti Sanae , Hamich Soumaya , Znati Kawtar , Meziane Mariame , Ismaili Nadia , Benzekri Leila , Senouci Karima
Published: January 2022

Sir, CD8+ mycosis fungoides (MF) is a rare form of MF with an indolent course. Herein, we report a rare case of CD8+ fungoid mycosis preceded by lymphomatoid papulosis type D with an aggressive course. A 36-year-old female presented with several papular lesions on the trunk and extremities with a relapsing–remitting course. Histopathology and an immunohistochemical study confirmed CD8-positive lymphomatoid papulosis type D and methotrexate at 25 mg/week was initiated. After a temporary clinical improvement, the lesions worsened, became infiltrated, and grouped as vaguely annular and angular patches with serpiginous borders (Fig. 1). A second scalp biopsy was performed and a diagnosis of CD8+ MF was established. An extension workup was normal, and MF was classified as stage IB. PUVA therapy was started with acitretin at 25 mg/day. After four weeks from the beginning of treatment, the patches completely disappeared but with the concomitant appearance of four subcutaneous tumors. The evolution was spectacular in fifteen days, with the tumors rapidly increasing in size, becoming ulcerative and necrotic, and one being localized in the left cervical area compressing the upper respiratory tract (Fig. 2). A subsequent biopsy revealed massive epidermal and dermal large cell infiltration (Fig. 3a); the tumor cells were positive for CD3, CD8, and CD7 (Fig. 3b) and negative for CD4, CD5, CD3, CD2, and CD30. Antigen Ki-67 was expressed by more than 80% of T-cells (Fig. 3c). A cerebral and thoraco-abdominal CT scan revealed multiple axillary lymph nodes with hypermetabolism on a PET scan. An osteomedullar biopsy was normal, and lactate dehydrogenase (LDH) was increased to 358 U/L. Chemotherapy was performed, but the patient died after two cycles of CHOEP. In contrast to classical CD4+ mycosis fungoides, CD8+ MF is a rare cytotoxic phenotype constituting about 5% of all cases of MF [1]. It belongs to the first group of primary cytotoxic cutaneous lymphomas (PCCL) with a good prognosis, an indolent course, and a slow progression of the lesions over several years [2]. However, rare cases with a more aggressive course have been reported in the literature [3]. The main differential diagnosis of aggressive CD8+ MF is an aggressive epidermotropic cutaneous CD8+ lymphoma that is a rare cutaneous lymphoma with a poor prognosis due to rapid extracutaneous dissemination [4]. The prognosis of the CD8+ subtype of mycosis fungoides (MF) is controversial. More studies are necessary to clarify this subject.
Pulse dye laser therapy and superficial cryotherapy as a novel combination treatment for hypertrophic scars and keloids
Authors: Bukhari Iqbal A.
Published: January 2022

Background: Hypertrophic scars are benign and fibrotic skin lesions caused by defects in the regulation of cellularity during the wound-healingprocess, in which there is higher collagen production and less degradation. Genetic predisposing factors and different skin injuries may play a role in developing these types of lesions. On the other hand, keloids are overgrowths of fibrous tissue outside the original boundaries of trauma, yet these may also occur spontaneously. There are numerous treatment options for both conditions, including silicone gel sheeting, pressure therapy, intralesional triamcinolone acetonide, radiation, laser therapy, cryosurgery, interferon, 5-fluorouracil, and surgical excision as well as a multitude of extracts and topical agents. Objective: The objective was to evaluate the effectiveness of pulse dye laser (PDL) therapy and superficial cryotherapy as a combination treatment for hypertrophic scars and keloids. Method: Four Arabic female patients were seen at the outpatient clinic of the Department of Dermatology at the King Fahd Hospital of the University in Khobar, Saudi Arabia. The patients had keloids and hypertrophic scars. Treatment with cryotherapy every week for three weeks followed by one session of pulsed dye laser was administered rotationally for three to six months until the lesions displayed remarkable physical improvement or complete resolution. Results: All patients experienced significant improvement, showing a reduction in the size, erythema, pliability, and pruritus. None of the hypertrophic scars or keloids deteriorated during the one year of treatment. No complications were noted during the treatment period. Conclusion: Sequential PDL therapy combined with superficial cryotherapy may be an option for treating hypertrophic scars and keloids.
Zoster infection after vaccination with the AstraZeneca COVID-19 vaccine: A case report
Authors: Dupoirieux Laurent
Published: January 2022

Herein, we present the case of a 55-year-old patient who developed a severe zoster reaction after receiving the AstraZeneca COVID-19 vaccine. Although zoster reactivation has already been observed with various vaccines, the extent and length of this reaction raise serious concerns. Hopefully, the outcome of this patient was favorable. The case of this patient, who could have only received a single dose of the vaccine, suggests that immunity after this type of vaccine vanishes rapidly and booster shots will be of crucial importance in the future.
Estimasi Biaya dan Evaluasi Program Intervensi Pemberian Pangan Olahan untuk Keperluan Medis Khusus (PKMK) untuk Perbaikan Status Gizi di Banyumas, Jawa Tengah
Authors: Hasnur Hanifah , Presilawati Febyolla
Published: January 2022

Pemerintah Banyumas telah melaksanakan suatu intervensi Pemberian Pangan Olahan untuk Keperluan Medis Khusus (PKMK) dengan suplementasi nutrisi 1.5 kcal/mL pada tahun 2019. Namun, belum pernah dilakukan evaluasi baik dari segi luaran maupun biaya intervensi. Sehingga, penelitian ini diperlukan guna memberikan gambaran awal mengenai sumber daya yang dibutuhkan untuk perumusan perencanaan intervensi pada masa yang akan datang. Penelitian ini bertujuan untuk mengetahui estimasi biaya yang dibutuhkan untuk intervensi PKMK dan mengetahui luaran dari intervensi. Evaluasi ekonomi dilakukan secara parsial dengan menghitung biaya dari perspektif institusi pelaksana program dan hasil luaran dari intervensi berupa peningkatan BB dan TB. Sampel penelitian sebanyak 40 balita yang telah dipilih berdasarkan skrining gizi balita yang tidak mampu mengkonsumsi makanan yang ada dan memiliki asupan nutrisi yang inadekuat. Hasil studi menunjukkan total biaya intervensi sebesar Rp.219.817.000 untuk 40 anak (Rp.5.495.438 per anak) di mana untuk suplementasi nutrisi 1.5 kcal/mL per anak sebesar Rp.1.395.850. Terjadi peningkatan rata-rata berat dan tinggi anak sebesar 0.64-kilogram dan 0.47-centimeter dalam 28 hari setelah program selesai. Estimasi biaya dari hasil studi ini dapat lebih rendah pada intervensi selanjutnya apabila peralatan yang ada digunakan kembali. Studi ini dapat dijadikan referensi untuk pelaksanaan intervensi PKMK dengan lingkup cakupan / kriteria subjek yang sama atau dalam skala yang lebih luas.
Exploring Educative Components to Conceptualize an Effective Implementation of Reading Discipline Curricula in Pre-service Teacher-Education Program
Authors: Mirza Nida , Razak Rafiza Abdul , Salleh Umi Kalsum Mohd
Published: January 2022

The curriculum implementation literature has recently focused more on identifying and measuring the key components of the innovative curriculum needed to achieve desired outcomes. However, most of this work centers on curriculum implementation external to the field of teacher education.
In this article, we report on our identification of the educative components that form one component of the framework for conceptualizing the implementation of newly developed reading curricula for a Bachelor of Education Elementary program. The results suggest that prerequisite knowledge
about reading instruction and knowledge of the entire reading program are necessary for an effective implementation of curriculum change in the discipline of reading.
The Design of Curriculum in Human Education Through Daisaku Ikeda Children’s Stories
Authors: Kuo Nai-Cheng , Ramsey Jennifer
Published: January 2022

Human education teaches students that everyone has value, and each person should embrace their uniqueness, knowing diversity creates richness, not conflict, in the world. It is essential to show teachers concrete examples about how to create an environment where students can practice
dialogue skills, develop global citizens’ character, and embrace their individuality. In this regard, our instructional design on human education may help teachers and researchers see the practicability of connecting humanity with K-12 curricula as well as develop a newfound respect
for the need for human education.
Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
Authors: Ambrosi Giulia , Voloshanenko Oksana , Eckert Antonia F , Kranz Dominique , Nienhaus G Ulrich , Boutros Michael
Published: January 2022

Wnt signaling plays important roles in development, homeostasis, and tumorigenesis. Mutations in β-catenin that activate Wnt signaling have been found in colorectal and hepatocellular carcinomas. However, the dynamics of wild-type and mutant forms of β-catenin are not fully understood. Here, we genome-engineered fluorescently tagged alleles of endogenous β-catenin in a colorectal cancer cell line. Wild-type and oncogenic mutant alleles were tagged with different fluorescent proteins, enabling the analysis of both variants in the same cell. We analyzed the properties of both β-catenin alleles using immunoprecipitation, immunofluorescence, and fluorescence correlation spectroscopy approaches, revealing distinctly different biophysical properties. In addition, activation of Wnt signaling by treatment with a GSK3β inhibitor or a truncating APC mutation modulated the wild-type allele to mimic the properties of the mutant β-catenin allele. The one-step tagging strategy demonstrates how genome engineering can be employed for the parallel functional analysis of different genetic variants.
Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease
Authors: Shabir Osman , Pendry Ben , Lee Llywelyn , Eyre Beth , Sharp Paul S , Rebollar Monica A , Drew David , Howarth Clare , Heath Paul R , Wharton Stephen B , Francis Sheila E , Berwick Jason
Published: January 2022

Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including dementia. In this study, we examined cortical haemodynamics in mouse preparations that modelled Alzheimer’s disease (J20-AD) and atherosclerosis (PCSK9-ATH) between 9 and 12 m of age. We report novel findings with atherosclerosis where neurovascular decline is characterised by significantly reduced blood volume, altered levels of oxyhaemoglobin and deoxyhaemoglobin, in addition to global neuroinflammation. In the comorbid mixed model (J20-PCSK9-MIX), we report a 3 x increase in hippocampal amyloid-beta plaques. A key finding was that cortical spreading depression (CSD) due to electrode insertion into the brain was worse in the diseased animals and led to a prolonged period of hypoxia. These findings suggest that systemic atherosclerosis can be detrimental to neurovascular health and that having cardiovascular comorbidities can exacerbate pre-existing Alzheimer’s-related amyloid-plaques.
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
Authors: Tsai Kaitlyn , Stojković Vanja , Noda-Garcia Lianet , Young Iris D , Myasnikov Alexander G , Kleinman Jordan , Palla Ali , Floor Stephen N , Frost Adam , Fraser James S , Tawfik Dan S , Fujimori Danica Galonić
Published: January 2022

Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the peptidyl transferase center, resulting in the C-8 methylation of A2503 (m8A2503). Acquisition of cfr results in resistance to eight classes of ribosome-targeting antibiotics. Despite the prevalence of this resistance mechanism, it is poorly understood whether and how bacteria modulate Cfr methylation to adapt to antibiotic pressure. Moreover, direct evidence for how m8A2503 alters antibiotic binding sites within the ribosome is lacking. In this study, we performed directed evolution of Cfr under antibiotic selection to generate Cfr variants that confer increased resistance by enhancing methylation of A2503 in cells. Increased rRNA methylation is achieved by improved expression and stability of Cfr through transcriptional and post-transcriptional mechanisms, which may be exploited by pathogens under antibiotic stress as suggested by natural isolates. Using a variant that achieves near-stoichiometric methylation of rRNA, we determined a 2.2 Å cryo-electron microscopy structure of the Cfr-modified ribosome. Our structure reveals the molecular basis for broad resistance to antibiotics and will inform the design of new antibiotics that overcome resistance mediated by Cfr.
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Authors: López-Hernández Tania , Takenaka Koh-ichiro , Mori Yasunori , Kongpracha Pornparn , Nagamori Shushi , Haucke Volker , Takamori Shigeo
Published: January 2022

Neurotransmission is based on the exocytic fusion of synaptic vesicles (SVs) followed by endocytic membrane retrieval and the reformation of SVs. Conflicting models have been proposed regarding the mechanisms of SV endocytosis, most notably clathrin/adaptor protein complex 2 (AP-2)-mediated endocytosis and clathrin-independent ultrafast endocytosis. Partitioning between these pathways has been suggested to be controlled by temperature and stimulus paradigm. We report on the comprehensive survey of six major SV proteins to show that SV endocytosis in mouse hippocampal neurons at physiological temperature occurs independent of clathrin while the endocytic retrieval of a subset of SV proteins including the vesicular transporters for glutamate and GABA depend on sorting by the clathrin adaptor AP-2. Our findings highlight a clathrin-independent role of the clathrin adaptor AP-2 in the endocytic retrieval of select SV cargos from the presynaptic cell surface and suggest a revised model for the endocytosis of SV membranes at mammalian central synapses.
Genetic basis and dual adaptive role of floral pigmentation in sunflowers
Authors: Todesco Marco , Bercovich Natalia , Kim Amy , Imerovski Ivana , Owens Gregory L , Dorado Ruiz Óscar , Holalu Srinidhi V , Madilao Lufiani L , Jahani Mojtaba , Légaré Jean-Sébastien , Blackman Benjamin K , Rieseberg Loren H
Published: January 2022

Variation in floral displays, both between and within species, has been long known to be shaped by the mutualistic interactions that plants establish with their pollinators. However, increasing evidence suggests that abiotic selection pressures influence floral diversity as well. Here, we analyse the genetic and environmental factors that underlie patterns of floral pigmentation in wild sunflowers. While sunflower inflorescences appear invariably yellow to the human eye, they display extreme diversity for patterns of ultraviolet pigmentation, which are visible to most pollinators. We show that this diversity is largely controlled bycis-regulatory variation affecting a single MYB transcription factor, HaMYB111, through accumulation of ultraviolet (UV)-absorbing flavonol glycosides in ligules (the ‘petals’ of sunflower inflorescences). Different patterns of ultraviolet pigments in flowers are strongly correlated with pollinator preferences. Furthermore, variation for floral ultraviolet patterns is associated with environmental variables, especially relative humidity, across populations of wild sunflowers. Ligules with larger ultraviolet patterns, which are found in drier environments, show increased resistance to desiccation, suggesting a role in reducing water loss. The dual role of floral UV patterns in pollinator attraction and abiotic response reveals the complex adaptive balance underlying the evolution of floral traits.