bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling oxygen (18O, 17O, 16O) and hydrogen (2H, 1H) water isotopes in the coupled numerical climate model iLOVECLIM (version 1.1.5)
Authors: Extier Thomas , Caley Thibaut , Roche Didier M.
Published: July 2023

Abstract. Stable water isotopes are used to infer changes in the hydrological cycle for different climate periods in climatic archive and numerical climate models. Following previous developments of δ18O in the intermediate complexity model iLOVECLIM, we present here the implementation of the δ2H and δ17O water isotopes in the different components of this coupled numerical climate model, and calculate the d-excess and 17O-excess. Results of a 5,000 years equilibrium simulation under preindustrial conditions are analysed and compared to observations for the atmosphere and the ocean components. In the atmospheric component, the model correctly reproduces the first order global distribution of the δ2H and d-excess as observed in the data, even if local differences are observed. The latitudinal gradient is also correctly reproduced in our model and fits previous water isotopes enabled General Circulation Models simulations despite a simplified atmospheric component in iLOVECLIM. One exception is observed in Antarctica where the model does not correctly estimate the water isotope composition, consequence of the non-conservative behaviour of the advection scheme at very low moisture content. For the ocean, the model also simulates adequate isotopic composition in comparison to the observations, except for local areas such as in the surface Arabian Sea, a part of the Arctic and West equatorial Indian ocean. Data-model evaluation also presents a good match for the δ2H over the entire water column in the Atlantic Ocean, reflecting the influence of the different water masses. Modelled δ17O and 17O-excess are also evaluated against measurements for the two components of the model and compare to another General Circulation Model.
Hybrid-Lambda: A low specific rating rotor concept for offshore wind turbines
Authors: Ribnitzky Daniel , Berger Frederik , Petrovic Vlaho , Kühn Martin
Published: July 2023

Abstract. We introduce an aerodynamic rotor concept for an offshore wind turbine which is tailored for an increased power feed-in at low wind speeds by a substantial increase of the rotor diameter while maintaining the rated power. The main objective of the conceptual design is to limit the quasi-steady loads (blade flapwise root bending moment (RBM) and thrust) to the maximum values of a reference turbine. The outer part of the blade (i.e. outer 30 % span) is designed for a higher design tip speed ratio (TSR) and a lower axial induction than the inner part. By operating at the high TSR in light winds, the slender outer part fully contributes to the increased power capture. In stronger winds the TSR is reduced and the torque generation is shifted to the inner section of the rotor. Moreover, the blade design efficiently reduces the power losses when the flapwise RBM is limited through peak shaving, below rated wind speed. This is of high importance, given the wind speed distribution at offshore sites. The characteristics of the rotor are first investigated with stationary blade element momentum simulations and further analyzed with aeroelastic simulations, considering the flexibility of blades and tower to show that a structural design is feasible even for a blade of this size and complexity. The economic revenue and the cost of valued energy of the turbine is estimated and compared to the IEA 15 MW offshore reference turbine, considering a fictitious wind speed-dependent feed-in price. Our results for the turbine concept with an increase of rotor diameter by 36 % show that the revenue can be increased by 30 % and the cost of valued energy can be reduced by 16 % compared to the reference turbine.
Herméneutique et phénoménologie. Tensions autour de la religion
Authors: Camilleri Sylvain
Published: July 2023

Cet article interroge les tensions entre phénoménologie et herméneutique telles qu’elles se cristallisent dans le propos de Ricœur sur la religion, en particulier dans un texte tardif qui a connu plusieurs versions et qui est peut-être le seul où le philosophe aborde aussi directement les questions méthodologiques que soulève une phénoménologie de la religion. Nous tentons de montrer que Ricœur considère en quelque sorte cette dernière avec des œillères, au profit d’une herméneutique de la religion qui, pour modeste et prudente qu’elle soit, se voit forcée de renoncer à prendre en charge l’élucidation de la constitution originaire de l’expérience religieuse.
Prediction of Adherence through Illness Appraisal of Individuals with Diabetes: Role of Experiential Avoidance
Authors: Fayyaz Amna , Yusuf Shazia
Published: July 2023

In chronic diseases, illness appraisal and adherence to the treatment go hand in hand. Diabetes is a silent killer, and most of the time, the experiential avoidance of the patient leads to drastic consequences. The present study was conducted to investigate the relationship between illness appraisal and adherence, and the mediating role of experiential avoidance in this relationship among individuals with diabetes. For this purpose, the data was collected from 150 individuals with Type-I diabetes (n=71) and Type-II diabetes (n=79), recruited from hospitals in Islamabad using a cross-sectional research design. To assess illness appraisal, Brief Illness Perception Questionnaire (Broadbent et al., 2015); for adherence, General Medication Adherence Scale (Naqvi et al., 2018) and for experiential avoidance, Brief Experiential Avoidance Questionnaire (Gámez et al., 2013) were administered. It was hypothesized that 1) there is a negative relationship between adherence, illness appraisal, and experiential avoidance among individuals with diabetes. 2) Illness appraisal predicts adherence among individuals with diabetes. 3) Experiential avoidance mediates the relationship between illness appraisal and adherence among individuals with diabetes. Results indicated a significant negative relationship between adherence, illness appraisal, and experiential avoidance among individuals with diabetes. Results also highlighted that illness appraisal significantly predicted adherence among individuals with diabetes. Furthermore, experiential avoidance significantly mediated the relationship between illness appraisal and adherence among individuals with diabetes. Study results have important implications in clinical settings to improve the treatment process and consider all the other factors impacting adherence.
Didática da Geografia Progressiva: sentidos, racionalidade e linguagem
Authors: Nobre Carneiro Rosalvo , Lenilde de Araújo Raimundo
Published: July 2023

Fala-se em Didática na área de Geografia, ao menos, desde a primeira metade do século XX, ainda que, no tempo presente, não tenha se constituído como um campo temático sistematizado de estudo. Neste contexto, objetiva-se compreender os sentidos de Didática na Geografia Progressiva ou Moderna que se desenvolveu até 1970 aproximadamente. Especificamente, busca-se identificar se há a predominância do sentido instrumental de Didática e o lugar que ocupa, nela, a linguagem. Optou-se pela pesquisa bibliográfica, mediante a análise de artigos e manuais, publicados, entre 1950 e 1960, em bases de pesquisa e em periódicos. Este estudo está associado ao projeto de pós-doutorado junto ao Programa de Pós-Graduação em Geografia da Universidade Federal do Piauí. Os achados indicam que nem sempre se verifica o sentido manifesto de Didática nos estudos e propostas didáticas em Geografia. Além disso, a concepção de Didática se relaciona à racionalidade e à ação instrumental. A linguagem, em sua função de entendimento, não é referida nos estudos analisados. Conclui-se que há confusões entre Didática e Metodologia, que os elementos da Didática da Geografia são variáveis e que a linguagem não ocupa centralidade nas Didáticas da Geografia produzidas no período.
Ինչո՞ւ է դանդաղել Հայաստանի գյուղատնտեսության աճը. խնդիրներ և լուծումներ / LICY
WHY DID THE GROWTH OF AGRICULTURE SLOW DOWN IN ARMENIA?
PROBLEMS & SOLUTIONS
Authors: AVETISYAN Samvel , AVETISYAN Ashot
Published: July 2023

The economic growth of agriculture in Armenia has been very low for a long time. Even comprehensive measures of state support do not give the expected results. There are many reasons for this phenomenon, but the main reason is the small size of farms and the fragmentation of plots. As a result, the possibilities of digitalization, complex mechanization, the introduction of efficient irrigation systems and intensive agricultural technologies are limited.
The absence of the Ministry of Agriculture and the weakening of service infrastructures also have a negative impact on the production activities of the sector. As a result, even if the year is favorable, the producer regularly faces sharp fluctuations in the financial market, difficulties in selling the crop, lack of irrigation water, the spread of diseases and pests, and other problems. The geopolitical tensions and conflicts of recent years also affect the development of agriculture, foreign trade in food products and
means of production and aggravate the problem of food security.
This article presents the state of agriculture in Armenia in recent years, assesses the reasons for the slowdown in economic growth and proposes measures to overcome them.
Թանգարանային զբոսաշրջության զարգացման միտումներն աշխարհում և Հայաստանում / MUSEUM TOURISM DEVELOPMENT TRENDS IN THE WORLD AND IN ARMENIA
Authors: TOVMASYAN Gayane
Published: July 2023

Museum tourism is a type of cultural tourism whereby tourists visit museums to get acquainted with certain values of historical and cultural heritage. Museum tourism market estimated at 20 billion US dollars in 2022. According to UNESCO, currently there are approximately 104,000 museums in the world, with the largest number of museums being located in the USA, totaling 33,082 museums. Among the best museums in the world are: Louvre, Metropolitan Museum of Art, Hermitage, Vatican Museums, Uffizi Gallery, Orsay, Prado, British Museum, and others. This paper presents the world's best museums, as well as unique museums, types of museum visitors, museum tourism development trends in the world in recent years, the main marketing tools used by museums to attract visitors. The analysis extends to the museum sector in the RA offering insights into necessary steps for the development of museum tourism.
OPTIMASI MPPT PANEL SURYA SERIES-PARALLEL MODEL UNTUK MENGATASI PARTIAL SHADING CONDITION DENGAN METODE P&O
Authors: Hajah M.Sohibul
Published: July 2023

Optimasi Maximum Power Point Tracking (MPPT) merupakan aspek penting dalam pengembangan sistem fotovoltaik (PV) untuk memaksimalkan pengambilan daya dari panel surya. Dalam penelitian ini, kami memfokuskan pada optimasi MPPT pada sistem PV yang terhubung secara series-paralel menggunakan metode Perturb and Observe (P&O). Kami mengidentifikasi bahwa sistem PV series-paralel menghadapi tantangan yang berbeda dibandingkan dengan sistem PV yang terhubung secara individu. Ketidakcocokan daya dan kondisi kerja yang berbeda di antara modul PV yang terhubung secara seri dan paralel dapat mengurangi kinerja MPPT secara keseluruhan. Oleh karena itu, kami mengusulkan strategi optimasi yang memperbaiki masalah ini. Strategi optimasi yang diusulkan menggabungkan teknik penyesuaian skala daya dan algoritma kontrol adaptif. Teknik penyesuaian skala daya digunakan untuk mengkompensasi perbedaan daya antara modul PV yang terhubung secara seri dan paralel, sehingga mencapai kesetimbangan yang optimal. Algoritma kontrol adaptif digunakan untuk mengoptimalkan langkah perturbasi agar mencapai kestabilan dan akurasi yang lebih baik dalam melacak titik daya maksimum. Kami melakukan simulasi dengan membangun model sistem PV series-paralel yang mempertimbangkan karakteristik fisik dan elektrik dari modul PV serta variasi intensitas cahaya matahari. P&O dibangun menggunakan Simulink matlab 2020b dengan boost converter. Pada penelitian ini P&O memiliki kecepatan tracking 850.2 ms dengan akurasi 99.95%. Penelitian ini memiliki implikasi penting dalam pengembangan teknologi PV yang lebih efisien dan dapat diterapkan dalam skala besar. Metode optimasi MPPT yang diusulkan dapat menjadi landasan untuk pengembangan sistem PV series-paralel yang handal dan efektif dalam memaksimalkan penyerapan daya dari panel surya. Selain itu, pendekatan ini dapat menjadi dasar untuk penelitian lanjutan dalam mengoptimalkan MPPT pada sistem PV dengan kondisi yang lebih kompleks dan dinamis
IMPACT OF MORTGAGE LENDING AND STATE FINANCING PROGRAMS ON THE CONSTRUCTION INDUSTRY OF KAZAKHSTAN
Authors: Омарова А.Т. , Баткеева Д.Р. , Сапарова Б.С. , Сраилова Г.Н. , Batkeeva D. , Omarova A. , Saparova B. , Srailova G.
Published: July 2023

В статье рассматривается влияние ипотечного кредитования и госпрограмм финансирования на строительную отрасль Казахстана. В ходе исследования авторами была выдвинута гипотеза о дальнейшем росте показателей ипотечного кредитования в строительном секторе Республики Казахстан в условиях трансформации геополитической и экономической ситуации в мире с использованием методов математического моделирования и прогнозирования и применения регрессионного анализа. Помимо своей социальной значимости, развитие ипотечного кредитования способствует сбалансированному развитию финансовой системы страны и сохранению ее стабильности, а также стимулирует развитие строительного сектора экономики, способствуя окупаемости проектов за счет увеличения спроса на жилье среди населения. На основе полученных результатов был сделан вывод о том, что ипотечное кредитование играет важную роль в развитии строительной отрасли Республики Казахстан, поэтому необходимо уделять большое внимание таким фактам, как различные кредитные инструменты и государственное финансирование программ. Результаты исследования имеют теоретическое и практическое значение и подтверждают гипотезу автора о дальнейшем росте показателей ипотечного кредитования в строительном секторе Республики Казахстан и развитии программ государственного финансирования этой отрасли.

The article examines the impact of mortgage lending and state financing programs on the construction industry of Kazakhstan. In the course of the study, the authors put forward a hypothesis about the further growth of mortgage lending indicators in the construction sector of the Republic of Kazakhstan in the context of the transformation of the geopolitical and economic situation in the world using mathematical modeling and forecasting methods and the use of regression analysis. In addition to its social significance, the development of mortgage lending contributes to the balanced development of the country's financial system and maintaining its stability, as well as stimulates the development of the construction sector of the economy, contributing to the payback of projects by increasing the demand for housing among the population. Based on the results obtained, it was concluded that mortgage lending plays an important role in the development of the construction industry of the Republic of Kazakhstan, therefore, it is necessary to pay great attention to such facts as various credit instruments and state financing of programs. The results of the study have theoretical and practical significance and confirm the author's hypothesis about the further growth of mortgage lending indicators in the construction sector of the Republic of Kazakhstan and the development of public financing programs for this industry.
Service Demand and Employee Benefits Provision in Local Governments
Authors: Jong Jaehee
Published: July 2023

Researchers who study organization-environment adaptation argue that organizations adapt to demanding situations in their environment to maintain sustainability. Along these lines, when local governments face increased service responsibilities and needs, they generally attempt to adjust their managerial practices in order to enhance organizational outcomes. Drawing insights from two theoretical perspectives—organizational adaptation and resource-based view—the current study identifies service demand as an environmental factor that influences organizations’ managerial practices and employee benefits provision as an organizational adaptation. Using survey data from officials (n = 225) who work for township governments in Illinois in the U.S. and U.S. census data, the analysis found that benefit provision was related to service demand increases, suggesting that organizations facing high levels of service demand may seek ways to retain current staff or attract new staff, such as providing additional employee benefits programs, in order to meet the increasing service demand.
Public Participation and Trust in Government: Results From a Vignette Experiment
Authors: Campbell Jesse W.
Published: July 2023

Securing the trust of citizens can facilitate the delivery of high-quality public services and government has a duty to act in a trustworthy manner. However, even if public service quality is high and policy sound, if decisions are made without accountability, trust in government may suffer. Public participation can contribute to the legitimacy of the exercise of government power. Using a two-by-two vignette-based experiment embedded in a survey conducted in South Korea, I test the impact on trust in government of public participation in the policymaking process under conditions of both good and poor policy performance. The results suggest that participatory policymaking marginally increases citizen trust in government. However, they also suggest that performance is the critical factor, and that participation alone cannot reverse the trust-damaging effect of poor performance. Although this research has limitations, it also has practical implications for public managers considering involving the public in the policymaking process, particularly when the costs of doing so are non-trivial.
Rotary File Systems Designed Exclusively for Pediatric Patients: A Literature Review
Authors: Kaushik Himani , Singhal Ruchi , Kakram Anisha
Published: July 2023

Pulpal treatment in deciduous teeth is done to maintain the tooth in position for proper function including mastication, phonation and preserving the arch length until the permanent teeth erupt. Pulpectomy is a conservative treatment approach in which pulp chamber and canals are accessed for cleaning and debridement followed by filling with a suitable material. Root canals in primary teeth are different from permanent teeth in being short, slender and more divergent with multiple accessory canals and continuously shifting apical foramen due to resorption. Therefore, the technique is sensitive in primary teeth. Conventional hand files were used initially then rotary system was introduced. NiTi rotary file system provide some of the advantages like short instrumentation time, cost-effective and consistent obturations along with improving patient’s cooperation. But there were various limitations of using adult rotary files in children because of larger file length and taper which causes lateral perforations and over-instrumentation. Hence, NiTi rotary files were designed for children. Kedo-S file system was the first file system to be introduced. After that, many systems have evolved specifically for children. The present literature review will discuss various rotary file systems available for children.

Key words: Pediatric endodontics, Pediatric NiTi rotary files, Pulpectomy.
Anatomical Variations of Renal Artery Studied by Computed Tomography in a Tertiary Care Center in Nepal
Authors: Paudyal Sudil , Kumar Gupta Manish , Adhikari Deepak
Published: July 2023

Background: Each kidney is normally supplied by a single renal artery originating from the abdominal aorta. A lot of renal surgeries are routinely done nowadays, so it has become increasingly necessary for surgeons to understand the abnormalities and variations in the renal vasculature. The aim of this study was to determine anatomical variations of renal arteries in the Nepalese population.
Materials and methods: This cross-sectional study was performed in the Department of Radiology and Imaging on a total of 125 patients (57 male and 68 female) of age range 18-65 years who underwent Contrast Enhanced Computed Tomography (CECT) of the abdomen from November 2020 to April 2021.
Results: Renal artery variations were found in 49.6% of the patients. Among them, 24% individuals had early hilar division of renal artery, 8.8% individuals had aberrant renal artery and 21.6% individuals had accessory renal artery. In early hilar division of renal artery, 13.6% individuals had right sided early hilar division, 7.2% individuals had left sided early hilar division and 3.2% individuals had bilateral early hilar division. In aberrant renal artery, 6.4% individuals had aberrant renal artery on right side and 2.4% individuals had aberrant renal artery on left side. In accessory renal artery, 8% individuals had accessory renal artery on right side, 11.2% individuals had accessory renal artery on left side and 2.4% individuals had bilateral accessory renal artery. The difference in prevalence of aberrant renal artery in males and females was statistically significant (p=0.05).
Conclusion: Renal artery variations are very common. Most common variations found in this study included early hilar division of renal artery, aberrant and accessory renal artery. The incidence of early hilar division of renal artery was more common than aberrant and accessory renal artery in our study population.

Key words: Anatomical variations, Computed tomography, CECT, Renal Arteries.
Concepções de criança, infância, educação infantil e contextualização da educação: o que dizem as professoras de escolas no\do campo.
Authors:   , Rodrigues Fernandes Josilene
Published: July 2023

Esta pesquisa vinculase ao Curso de Especialização em Educação Contextualizada para Convivência com o Semiárido da Universidade Federal de Campina Grande, Campus Sumé, e tem como objeto de pesquisa a concepção das professoras da Educação Infantil no\do campo sobre Infância, Educação Infantil e Contextualização. O objetivo geral do estudo foi o de Compreender as concepções de infância, educação infantil e contextualização das professoras da Educação Infantil no Campo no Município de São João do Cariri, e como objetivos específicos buscamos: identificar a relação entre o discurso normativo e as concepções expressas pelas professoras e identificar se, e quais os referenciais teóricos e práticos que na concepção das professoras influenciam na sua prática na Educação Infantil. A pesquisa teve um cunho qualitativo utilizando do procedimento bibliográfico para revisão da literatura e construção do referencial teórico sobre Infância: Ariès (1981), Heywood (2004), Kuhlmann. Jr (2004), Sarmento (2007), e Kramer (1984;1999;2009); Contextualização da Educação: a análise documental auxiliou na compreensão dos referencias legais da política educacional, nos quais buscamos identificar a conceituação, princípios e fundamentos da Educação Infantil. Para identificar as concepções das professoras sobre a temática, e quais os referenciais teóricos que influenciam sua prática docente utilizamos um questionário semiestruturado, que após sua tabulação e organização dos principais indicadores, realizamos uma roda de conversa online para aprofundamento dos núcleos de significação que emergiram do material. Como resultados do estudo identificamos um grupo em sua maioria jovem, com menos de doze anos de prática na Educação Infantil, que colocam o gostar de trabalhar com essa faixa etária como central no seu trabalho, que muito recentemente passaram a ter formação continuada para atuação nesta etapa, e que, portanto, passaram a se apropriar no que está previsto nas diretrizes da educação. A visão da Infância na perspectiva cronológica e biológica ainda é muito presente no grupo, embora já comecem a perceber que existem diferentes infâncias, e que, portanto, a criança como um sujeito histórico, ativo e criativo também constrói infâncias. A legislação específica da Educação Infantil ainda necessita ser melhor conhecida pelo grupo, bem como o aprofundamento nos referenciais teóricos que tratam sobre a Educação Infantil no\do Campo. A contextualização da Educação é algo muito novo na sua reflexão teórica, e consideram que não se encontra presente em suas práticas, assim, sinalizam que os principais referenciais para seu trabalho são provenientes da troca de experiência e discussões com as colegas nos momentos de estudos e planejamentos e atualmente da Base Nacional Curricular da Educação Infantil.
“Eu num disse a tu que não era só filme”: o audiovisual no processo de ensino-aprendizagem da sociologia no ensino médio.
Authors:   , Araújo de Souza Alanny
Published: July 2023

O presente trabalho teve como objetivo principal discutir sobre os impactos causados pelo uso do audiovisual, esta linguagem/recurso (filme) onde as informações/conteúdos estão dispostos de forma dinâmica, nas aulas de Sociologia no Ensino Médio. Como objetivos específicos buscamos investigar como os recursos audiovisuais são usados nas aulas de Sociologia; analisar de que forma esses recursos contribuem para o processo de ensino aprendizagem e propôr estratégias pedagógicas utilizando o audiovisual. O referido estudo/intervenção pedagógica foi desenvolvido na Escola Estadual de Ensino Fundamental e Médio Maria Balbina Pereira, localizada no distrito de Santa Luzia do Cariri, município de Serra Branca, com alunos do 1°, 2° e 3° ano do Ensino Médio. A metodologia adotada contou com a abordagem qualitativa-observação participante elegendo como instrumentos de coleta de dados e de intervenção os seguintes: 1) observação na sala de aula, 2) entrevista baseada no grupo focal, 3) diálogo com os alunos sobre os temas sociológicos, escolha e exibição dos filmes. Para análise dos dados adotamos o método de análise de conteúdo de Bardin (ANO). O estudo fundamentou-se principalmente nas teorias dos autores Galetti (2013), Kenski (2007), Ferreira (2010), Rosalia Duarte (2009), Adriana Fresquet (2017), Libanêo, (2013), entre outros que contribuíram significativamente para compor o aporte teórico deste trabalho, assim como, para o nosso entendimento sobre a importância do uso dos recursos audiovisuais para o ensino de Sociologia no Ensino Médio. Ao final da experiência apontamos que a linguagem/recurso audiovisual contribui no processo de ensino aprendizagem, bem como, na socialização dos sujeitos e na sua capacidade de apreender frações do real nas narrativas audiovisuais aguçando, portanto, o olhar crítico e a lógica de perceber, problematizar e interferir no mundo social.
Untreated Major Depression During Gestation: The Physical and Mental Implications in Women and Their Offspring
Authors: Quiñones Felipe , Winters Carlynn , Hu Lydia , Suvarnakar Advait
Published: July 2023

While postpartum depression has been extensively studied and is a concern surrounding major depression in women, the effects of major depression during pregnancy alone should also be considered. The purpose of this review article was to explore in longitudinal fashion, from neonate to adulthood, the lasting physical and mental implications that depression during gestation can present in offspring. Consideration of various sources pulled from the OVID Medline database yielded findings consistent with negative associations between gestational depression and offspring outcomes. In mothers, gestational depression presents with physical implications, such as preeclampsia and preterm delivery, leading to low birth weight and neurodevelopmental complications in neonates. As the children grow older, these complexities manifest as socioemotional, behavioral, and linguistic development delays presenting as increased incidence in attention-deficit/hyperactivity disorder diagnoses, parental attachment issues, and lower emotional and verbal IQ. Research regarding adolescents and adults is sparse in comparison with that of earlier stages, but there are studies that examine the developmental outcomes of certain mood disorders, such as generational depression, in the offspring of birthing parents with prenatal depression. This review presents an extended timeline of the effects of gestational major depression in offspring, and it provides suggestions for future research regarding underlying biological explanations and certain risk outcomes.
RP-HPLC Method Development and Validation for Simultaneous Estimation of Rutin and Quercetin in Morus alba L. leaf extract
Authors: Garg Sarita , Chahal Rubal , Kaushik Deepak , Kumar Rakesh , Mittal Vineet
Published: July 2023

Mulberry, which pertains to the Moraceae family and the genus Morus,has been used in medicine for ages because of its chemical composition and pharmacological action. The plant is recognized in traditional Chinese medicine for its antiphlogistic, diuretic, expectorant, and antidiabetic characteristics. The mulberry leaf is high in flavonoids, which have a variety of biological functions, including antioxidant potential. Quercetin, isoquercetin, rutin, isoquercitrin, quercitrin, luteolin, chlorogenic acid, and other flavonoids can be found in their leaves. The major constituents of total flavones in mulberry leaf extract are rutin and quercetin. The goal of the RP-HPLC approach was to design and validate a method for identifying these elements. HPLC (Shimadzu Technologies LC series) with UV-visible detector at 259nm and C18 column (250mm 4.6mm, 5µm particle size) was used to achieve chromatographic separation (Phenomenex Luna). Solvents (acetonitrile and 0.1 percent v/v solution of glacial acetic acid) were used in the isocratic elution mode. The run time was 10 minutes. The column temperature was 37 degrees Celsius with sample insertion volume 20µl and the flow velocity was 1ml/min. For quercetin and rutin, the devised method produced strong linearity, high accuracy, high precision, high repeatability, high robustness, and high ruggedness. For quercetin and rutin, the LOD and LOQs values were determined to be within acceptable levels.
Development and validation of UPLC method for simultaneous estimation of Darunavir, Cobicistat, Emtricitabine and Tenofovir alafenamide in bulk drug and pharmaceutical dosage form
Authors: Dadi Vamsi , Sowjanya G.
Published: July 2023

The main objective of the present study was to develop and validate a multicomponent analysis of Darunavir, Cobicistat, Emtricitabine and Tenofovir alafenamide in bulk drug and pharmaceutical dosage form by ultra-performance liquid chromatography (UPLC). The drugs were separated using HSS C18 (100mm × 2.1mm, 1.8µ particle size) column with mobile phase consisting of potassium dihydrogen phosphate, pH adjusted to 5.4 and acetonitrile in the composition of 60:40 %v/v operated in isocratic mode at a flow rate of 0.3 ml/min. The column temperature maintained at 30˚C and detection wavelength used was 260 nm. The retention time for Darunavir was found to be 1.04min, for Cobicistat it was 1.82 min, for Emtricitabine it was 2.28 min and for Tenofovir it was found to be 1.39min. The developed method was validated in accordance to the ICH guidelines. The method obeyed Beer’s law in the concentration range of 50 µg/ml- 300µg/ml for Darunavir, 7.5 µg/ml – 45 µg/ml for Cobicistat, 25µg/ml - 150µg/ml for Emtricitabine and 0.625 µg/ml – 3.75µg/ml for Tenofovir alafenamide, with correlation coefficient of 0.999. The % relative standard deviation for all the drugs was found to be less than two indicating the method to be precise. The mean % recovery was found to be within the limits for all the drugs indicating that the method to be accurate. The method was also found to be specific, robust and stable. From the forced degradation studies, it was concluded that the drugs were found to be stable when exposed to different stress conditions as the net degradation was found within the acceptance criteria. The developed method for the multicomponent analysis of Darunavir, Cobicistat, Emtricitabine and Tenofovir alafenamide using UPLC can be used for quality control and routine analysis in bulk drug and pharmaceutical dosage form.
Picroside-1-Phytovesicle: A novel approach for Antihepatotoxic activity
Authors: Vyas Amber , Singh Chauhan Nagendra , Jain Tripti , Singhai A.K. , Jain Vishal
Published: July 2023

Picroside-I, the irridoid glycoside component obtained from Picrorhiza kurroa Royal Ex. Benth. extract was stoichiometrically complexed with phospholipids to form Phytosome. These complexes were characterized by IR and 1H-NMR spectroscopy. The efficacy of phytosome formulation was determined by in vitro GIT absorption study which indicates greater absorption from gastrointestinal tract, resulted in higher plasma levels. The hepatic protection offered by phytosomes was studied against CCl4 induced hepatotoxicity and compared with picroside-I, by measuring bio-chemical parameters in terms of SGOT and SGPT enzyme levels. Phytosomes exhibited appreciable greater hepatoprotection than that of picroside-I alone. Therefore, phytosome can advantageously be used in acute and chronic liver disease of varying origin.
Clinical Study of Paediatric Ocular Trauma and its Assessment with Paediatric Ocular Trauma Score
Authors: Shirke D.B. , Karambelkar V. H. , Joshi B.S. , P. Bhattad Chirag , Jarag R. J.
Published: July 2023

The study aimed to evaluate and estimate the visual prognosis of paediatric ocular trauma using the Paediatric Ocular Trauma Score (POTS). The results showed that the most common causes of ocular injuries in children were during sports and play, followed by firecracker injuries. It is recommended that preventive measures, such as proper supervision and the use of safety gear, should be taken to avoid such injuries. The study suggests the use of mass media to promote safety procedures and the development of a standardised documentation system to facilitate research and improve emergency care services. The loss of vision can have a profound impact on a child's life, and health education about eye protection should be provided at schools, educational health centres, and sports academies. Ultimately, preventing and managing ocular trauma in paediatric patients requires a collaborative effort between parents, teachers, and doctors.
Oxiditive Stress biomarkers levels in blood sample of Iraqi Breast cancer patients
Authors: Saeed Hadi Hadeel , Abdulzahra Abbas Shaymaa
Published: July 2023

Background: Breast cancer is a malignant tumor arising from epithelial cells of glandular lacteferons ducts or terminal ductilobular unit (TDLM) of the breast which is affected by the oxidative stress and the defensive mechanisms against it. Objective: to reveal the correlation between the levels of superoxide dismutase (CuZn SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GR), reduced glutathione (GSH) and sulfhydryl groups (SH) with breast cancer with/without metast. Methods: A case control study was performed on 30 female patients with metastasized breast cancer, 30 female patients with non- metastasized breast cancer and 30 female patients with benign breast tumor. All patients were recruited from Al-Karama teaching hospital at Wasit city in Iraq, for the period from October 2021 to February 2022. Results: The levels of GSH-PX, GR, GSH, and sulfhydral groups were significantly reduced in breast cancer patients in comparison with healthy controls whereas SOD levels were upregulated in breast cancer patients in comparison with healthy controls subjected to the current study. Conclusions: It is concluded that the activities of superoxide dismutase (CuZn SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GR), as well as concentrations of reduced glutathione (GSH) and sulfhydryl groups (SH) have a significant impact on the pathogenisis and progression of breast cancer.
Development of Efficient Analytical method for the multicomponent analysis of Pravastatin Sodium and Nebivolol Hydrochloride in Bulk Drug by RP-HPLC
Authors: Sharma Shivani , Deep Ankalgi Amar , Devi Arti , Singh Ashawat Mahendra
Published: July 2023

Cardiovascular diseases are managed through multi drug regimens. For better patient compliance and cost effectiveness, desired therapeutic efficacy is achieved through combination of more than two drugs in single dosage form. Nebivolol Hydrochloride is β1 receptor blocker and Pravastatin sodium exhibits its pharmacological action through inhibition of cholesterol synthesis. Both drugs are therapeutically compatible and can be administered in single dose formulation. A review of the literature found that there was no effective strategy for the selected drug combination. As a result, an attempt was made to establish a simple, efficient, sensitive, specific, and rapid method for simultaneously estimating Pravastatin sodium and Nebivolol hydrochloride in bulk drugs using RP-HPLC.Column C-18 (Shim-pack) 250 x 4.6 mm, particle size 5 m, mobile phase acetonitrile and water in the ratio 20:80 at 257 nm were found to be the optimal chromatographic conditions. Pravastatin sodium and Nebivolol hydrochloride had retention times of 2.092 and 3.623 minutes, respectively, with average percentage recovery of 99.38% and 99.54%, respectively.The proposed technique was found to be in accordance with the guidelines of the International Conference on Harmonization (ICH).
Vitamin D and its Influence on Oral Health: A Literature Review
Authors: K. P Indumathi. , Sibyl S.
Published: July 2023

Vitamin D is a steroid hormone that has long been recognized for its function in calcium and phosphorus regulation and bone mineralization. As dentists, we are well aware of the role it plays in tooth growth and mineralization. Vitamin D, in addition to supporting calcium homeostasis, appears to control a variety of physiologic processes. Vitamin D deficiency though appears as a single element deficiency its impact on the entire human body is tremendous. It is a growing health issue but still awareness and the importance of maintaining adequate levels in the body is not known by most of the population. Vitamin D deficiency affects individuals of all ages, including those born to aged adults. In this article, we will be focusing on the function physiological action, and pharmacology of vitamin D. We will also review how vitamin D insufficiency affects dental caries, child oral health, periodontium, orthodontic tooth movement, and oral cancer.
Thực trạng và biện pháp xây dựng văn hóa nhà trường ở các trường tiểu học tại thị xã Chơn Thành, tỉnh Bình Phước
Authors: Nguyễn Văn Diễn
Published: July 2023

Văn hóa nhà trường có vai trò quan trọng và ảnh hưởng mạnh mẽ đến chất lượng của một cơ sở giáo dục. Việc xây dựng văn hóa nhà trường góp phần rèn luyện kỹ năng sống của học sinh, giúp các em thích nghi với xã hội, thích nghi với hoàn cảnh và ứng xử phù hợp với cuộc sống xung quanh. Trong tất cả các trường học, văn hóa được xây dựng trên các mối quan hệ như quan hệ giữa con người, thiên nhiên và cảnh vật; quan hệ giữa người với người; trong đó, mối quan hệ giữa giáo viên và học sinh đóng vai trò quan trọng nhất. Bài viết tập trung nghiên cứu thực trạng xây dựng văn hóa nhà trường và đề xuất một số biện pháp nhằm nâng cao chất lượng quản lý hoạt động xây dựng văn hóa nhà trường ở các trường Tiểu học tại thị xã Chơn Thành, tỉnh Bình Phước.
Ultravaluations and their Applications in Classical Propositional Logic
Authors: Krawczyk Krzysztof A.
Published: July 2023

The talk will be devoted to the notion of ultravaluation introduced in our recent paper published in Logica Universalis. We will focus on its applications for CPL which are analogous to the basic results in FOL achieved with the use of the well-known ultraproduct construction.
Guided bone regeneration in reconstruction of the jaw and role tissue engineering in dental membrane, a review of literature
Authors: Maryam Masoudi Rad  , Maedeh Banki  , Nikoo Ghadimi
Published: July 2023

Tooth loss can significantly impact the quality of human life, affecting overall well-being, appearance, and nutrition. In advanced dentistry, implant therapy has become a popular option for restoring edentulous regions. Guided Bone Regeneration (GBR) is a bone grafting technique that utilizes a protective barrier membrane to prevent soft tissue penetration. This study aims to review various GBR methods, focusing on topics such as bone resorption in the edentulous jaw, different types of GBR techniques, indications for GBR, and limitations associated with this approach.
THE ECONOMIC PAMPHLETEER: Agri-food corporations are not real people; why does it matter?
Authors: Ikerd John
Published: July 2023

First paragraph: Corporations are not real people. This may seem obvious, but for more than a hundred years the U.S. Supreme Court has recognized corporations as legal persons with many of the same constitutional rights as real people (Torres-Spelliscy, 2014). Why does it matter? Because corporations can do things that real people can’t and yet are immune to legal liabilities that real people must consider. The lack of economic com­petitiveness in agri-food markets is one conse­quence of treating corporations as real people. So is the lack of government protection of farm and food workers from exploitation and the natural environment from extraction and pollution. Recent examples include concerns about corporate price gouging following the COVID-19 pandemic (Reich, 2022) and the weakening of the Environ­mental Protection Agency’s authority to restrict corporate pollution (Feldscher, 2022). . . .
Internal fixator vs external fixator in the management of unstable pelvic ring injuries: A prospective comparative cohort study
Authors: Abo-Elsoud Mohamed , Awad Mostafa I , Abdel Karim Mahmoud , Khaled Sherif , Abdelmoneim Mohamed
Published: July 2023

Shoulder pain is a common musculoskeletal complaint, and rotator cuff (RC) pathologies are one of the main causes. The RC undergoes various tendinopathic and avascular changes during the aging process. Other degenerative changes affecting its healing potential make it an appealing target for biological agents. Platelet-rich plasma (PRP) has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators, and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle, ligaments, and tendinous cells. This review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical evidence. Due to the different characteristics and conflicting outcomes, clinicians should use PRP with moderate expectations until more consistent evidence is available. However, it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate healing. Its autologous origin makes it a safe treatment, and its characteristics make it a promising option for treating RC tendinopathy, but the efficacy has yet to be established.
Rezension von: Kuhn, Elmar L.; Renz, Peter (Hrsg): Geschichten aus Oberschwaben
Authors: Schwarzbauer Franz
Published: July 2023

Elmar L. Kuhn und Peter Renz (Hg): Geschichten aus Oberschwaben. Tübingen: Klöpfer & Meyer 2009; 400 S., 19,90 EUR
Rezension von: Prange, Melanie, Der Konstanzer Domschatz
Authors: Leistenschneider Eva , Prange Melanie
Published: July 2023

Der Konstanzer Domschatz. Quellentexte zu einem verlorenen Schatzensemble des Mittelalters und der Frühen Neuzeit (Veröffentlichungen der Kommission für geschichtliche Landeskunde in Baden-Württemberg. Reihe A, Quellen 56). Bearbeitet von Melanie Prange. Stuttgart: W. Kohlhammer Verlag 2012; 221 S., 14 Abb., geb., 22,00 EUR
Rezension von: Jasbar, Gerald, Faszination Holzschnitt
Authors: Schöllkopf Wolfgang , Jasbar Gerald
Published: July 2023

Gerald Jaspar: Faszination Holzschnitt. Illustrierte Wiegendrucke aus dem Tresor der Stadtbibliothek Ulm (Veröffentlichungen der Stadtbibliothek Ulm 24). Ulm: Süddeutsche Verlagsgesellschaft 2013; 123 S., zahlr. farb. Abb., geb., 25,50 EUR
Rezension von: Hoffmann, Andrea, Schnittmengen und Scheidelinien
Authors: Spohr Marc , Hoffmann Andrea
Published: July 2023

Andrea Hoffmann: Schnittmengen und Scheidelinien. Juden und Christen in Oberschwaben (Untersuchungen des Ludwig-Uhland-Instituts der Universität Tübingen im Auftrag der Tübinger Vereinigung für Volkskunde 110). Tübingen: Tübinger Vereinigung für Volkskunde e.V. 2011; 327 Seiten, 22,00 EUR
Revisiting the construction process of SUS: In search of a decolonial practice
Authors: Lemos Eliana de Jesus de Souza , Bezerra Teresa Christina da Cruz , Pereira Ester Miranda da Silva , Corrêa Sérgio Roberto Moraes , Bentes José Anchieta de Oliveira , Oliveira Ivanilde Apoluceno de , Sá Pedro Franco de
Published: July 2023

This article aims to revisit the process of building the Unified Health System (Sistema Único de Saúde - SUS) and analyze how it has been constructed and established as a decolonial practice, from its implementation to the present day. In this sense, we highlight some concepts presented by Maldonado-Torres (2018) as the basis for the present work, such as colonialism, modern colonialism, coloniality, decolonization, and decoloniality. Thus, analyzing SUS as a decolonial action implies observing a change in attitude throughout its history, a fundamental condition of antagonistic engagement with coloniality and in favor of decoloniality as a project. In this sense, decolonial action is essential to the decolonial project, and vice versa. To this end, the historical antecedents of the creation of SUS were analyzed, as well as its principles as practices of decoloniality. We observe, therefore, that the implementation of SUS can be considered a significant advancement. Even though it may be progressing slowly, it represents a decolonial strategy and action, especially by raising the need for an attitudinal change and listening to the one who has always been considered a secondary element in healthcare: the patient themselves.
CFD Simulation of isothermal upward two-phase flow in a vertical annulus using interfacial area transport equation
Authors: Ceravolo Flavio Eduardo , Rocha Marcelo da Silva , Mesquita Roberto Navarro de , Andrade Delvonei Alves de
Published: July 2023

This work presents a numerical simulation of a vertical, upward, isothermal two-phase flow of air bubbles and water in an annular channel applying a Computational Fluid Dynamics (CFD) code. For this, the Two-Fluid model is applied considering interfacial force correlations, namely: drag, lift, wall lubrication, turbulent dispersion, and virtual mass. The turbulence k-ε model effects and the influence of One-group Interfacial Area Transport Equation (IATE) are taken into account, in this case, the influence of two source term correlations for the bubble breakup and coalescence IATE is analysed. The work assesses whether the code properly represents the physical phenomenon by comparing the simulation results with experimental data obtained from the literature. Six flow conditions are evaluated based on two superficial liquid velocities and three void fractions in the bubbly flow regimen. The annular channel adopted has an outer pipe with an internal diameter of 38.1 mm and an inner cylinder of 19.1 mm. To represent this geometry, a three-dimensional mesh was generated with 160,000 elements, after a mesh sensitivity study. The void fraction distribution, taken radially to the flow section, is the main parameter analysed as well as interfacial area concentration, interfacial gas velocity, and bubble sizes distribution. The CFD model implemented in this work demonstrates satisfactory agreement with the reference experimental data but indicates the need for further improvement in the phase interaction models.