bluuebunny/crossref_metadata_2025 huggingface dataset:
Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration
Authors: Grange Cristina , Skovronova Renata , Marabese Federica , Bussolati Benedetta
Published: October 2019

Extracellular vesicles (EVs) are membranous vesicles containing active proteins, lipids, and different types of genetic material such as miRNAs, mRNAs, and DNAs related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. In fact, several reports provide convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells (MSCs) in different kidney injury models. Described mechanisms involve the reprogramming of injured cells, cell proliferation and angiogenesis, and inhibition of cell apoptosis and inflammation. Besides, the therapeutic use of MSC-EVs in clinical trials is under investigation. This review will focus on MSC-EV applications in preclinical models of acute and chronic renal damage including recent data on their use in kidney transplant conditioning. Moreover, ongoing clinical trials are described. Finally, new strategies to broaden and enhance EV therapeutic efficacy by engineering are discussed.
Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells
Authors: Tan Yanjie , Jin Yi , Wang Qian , Huang Jin , Wu Xiang , Ren Zhuqing
Published: October 2019

: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. Reactive oxygen species (ROS), as potent oxidants in cells, have been shown to promote the development of NAFLD. Previous studies reported that for ROS-induced cellular oxidative stress, promoting lipid droplet (LD) accumulation is associated with the cellular antioxidation process. However, the regulatory role of LDs in relieving cellular oxidative stress is poorly understood. Here, we showed that Perilipin 5 (PLIN5), a key LD protein related to mitochondria–LD contact, reduced ROS levels and improved mitochondrial function in HepG2 cells. Both mRNA and protein levels of PLIN5 were significantly increased in cells with hydrogen peroxide or lipopolysaccharide (LPS) treatment (p < 0.05). Additionally, the overexpression of PLIN5 promoted LD formation and mitochondria–LD contact, reduced cellular ROS levels and up-regulated mitochondrial function-related genes such as COX and CS. Knockdown PLIN5, meanwhile, showed opposite effects. Furthermore, we identified that cellular oxidative stress up-regulated PLIN5 expression via the JNK-p38-ATF pathway. This study shows that the up-regulation of PLIN5 is a kind of survival strategy for cells in response to stress. PLIN5 can be a potential therapeutic target in NAFLD.
Cactus Mucilage for Food Packaging Applications
Authors: Gheribi Rim , Khwaldia Khaoula
Published: October 2019

Natural polymers have been widely investigated for the development of eco-friendly materials. Among these bio-polymers, cactus mucilage is attracting increasing interest regardless of the plant species or the plant organ used for extraction. Mucilage, which is a highly branched heteropolysaccharide, has been previously studied for its chemical composition, structural features, and biotechnological applications. This review highlights the mucilage application in the food packaging industry, by developing films and coatings. These cactus-based biomaterials will be discussed for their functional properties and their potential in preserving food quality and extending shelf life.
Boron and Nitrogen Co-Doped Porous Carbons Synthesized from Polybenzoxazines for High-Performance Supercapacitors
Authors: Bai Lijun , Ge Yanping , Bai Lizhong
Published: October 2019

Boron and nitrogen co-doped porous carbons (BNPC-X) were synthesized from boron-containing polybenzoxazines through carbonization and chemical activation, where X represents the weight ratio of boric acid to benzoxazine resin. The as-prepared BNPC-X were characterized by X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, element analysis and electrochemical measurements. The results show that the BNPC-0.15 possesses relatively high weight fractions of boron (2.97 wt %) and nitrogen (2.43 wt %), a homogeneous pore distribution, and remarkable electrochemical capacitive performance. It exhibits high specific capacitance (286 F·g−1 at 0.05 A·g−1), excellent rate capability (at A·g−1), and good charge–discharge stability (>92% capacitance retention after 1,000 cycles at 1.0 A·g−1) in 6 M KOH aqueous solution.
Twisted Graphene Bilayers and Quasicrystals: A Cut and Projection Approach
Authors: Aragón José L. , Naumis Gerardo G. , Gómez-Rodríguez Alfredo
Published: October 2019

In this work, a modified version of the cut and projection approach is proposed to describe the structure of graphene bilayers with twist angles. With this method, the rotation between two graphene layers is viewed as a rotation of the projection space and the resulting projected structure is interpreted as the set of points of best fit between the two rotated structures. Additionally, focus is given to the pertinence of the many algebraic and geometric tools used in grain boundaries and in quasicrystals to graphene bilayer system (or any other bilayer system, for that matter) case.
Co-Crystal with Unusual High Z′ and Z′′ Values Derived from Hexamethylenetetramine and 4-fluorophenol (1/1)
Authors: Rivera Augusto , Sadat-Bernal John , Ríos-Motta Jaime , Bolte Michael
Published: October 2019

The title co-crystal, 1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane (HMTA, 1)–4-fluorophenol (4-FP) (1/1), C6H12N4·C6H5FO, shows an unusual asymmetric unit that comprises eight independent molecules (Z′′ = 8), four for each component, with four formula units per asymmetric unit (Z′ = 4). In the molecular packing, each HMTA molecule bridges one 4-FP molecule via an O−H···N hydrogen bond to form a two-molecule aggregate. Differences can be observed between the bond lengths and angles of the independent HMTA and 4-FP molecules and those of the molecules in the aggregate. The C−N bonds exhibit different bond lengths in the tetrahedral cage-like structure of the HMTA molecules, but the largest differences between the molecular aggregates are in the bond lengths in the 4-fluorophenol ring. In the crystal, the HMTA and 4-FP molecules form two hydrogen-bonded (O−H···N, C−H···F and C−H···O) dimers of HMTA and 4-FP molecules, A···D and B···C inversion dimers, which generate enlarged R88(34) ring motifs in both supramolecular structures. In both structures, the crystal packing also features additional C−H···F and C−H···O interactions. The A···D and B···C dimers are linked by additional C−H···F and C−H···O hydrogen bonds, forming columns along the a and b axes, respectively. The importance of the C−H···F interaction to the structure and crystal packing has been demonstrated.
A New High-Pressure Phase Transition in Natural Gedrite
Authors: Yong Tommy , Bina Craig R. , Finkelstein Gregory J. , Zhang Dongzhou , Dera Przemyslaw
Published: October 2019

High-pressure diamond-anvil cell synchrotron X-ray diffraction experiments were conducted on single-crystal samples of natural orthoamphibole; gedrite; with composition; (K0.002Na0.394)(Mg2)(Mg1.637Fe2.245Mn0.004Ca0.022Cr0.003Na0.037Al1.052)(Si6.517Al1.483)O22(OH)2. The samples were compressed at 298 K up to a maximum pressure of 27(1) GPa. In this pressure regime, we observed a displacive phase transition between 15.1(7) and 21(1) GPa from the orthorhombic Pnma phase to a new structure with space group P21/m; which is different from the familiar P21/m structure of cummingtonite and retains the (+, +, −, −) I-beam stacking sequence of the orthorhombic structure. The unit cell parameters for the new phase at 21(1) GPa are a = 17.514(3), b = 17.077(1), c = 4.9907(2) Å and β = 92.882(6)°. The high-pressure P21/m phase is the first amphibole structure to show the existence of four crystallographically distinct silicate double chains. The orthorhombic to monoclinic phase transition is characterized by an increase in the degree of kinking of the double silicate chains and is analogous to displacive phase changes recently reported in orthopyroxenes, highlighting the parallel structural relations and phase transformation behavior of orthorhombic single- and double-chain silicates.
Voltage-Balancing Strategy for Three-Level Neutral Point Clamped Cascade Converter under Sequence Pulse Modulation
Authors: Yu Le , Peng Xu , Gao Shibin
Published: October 2019

In response to the unbalanced DC-port fault of three-level neutral point clamped cascaded converter (3LNPC-CC), a sequence pulse modulation (SPM) voltage-balancing strategy is proposed in this paper to balance DC-link voltage, not only within the module but also among modules. With the steps of carrier cascaded calculation and sequence pulse generator, the voltage level of cascaded modules would take a smooth transition. Then the limitation of the SPM strategy is calculated according to the law of volt-second balance and the law of energy conservation. The proposed strategy has the advantage of simple calculation and control stability. Simulation and experimental results show the superiority of the proposed strategy.
Topography Affects Tree Species Distribution and Biomass Variation in a Warm Temperate, Secondary Forest
Authors: Wang Shunzhong , Qi Guang , Knapp Benjamin O.
Published: October 2019

A thorough understanding of carbon storage patterns in forest ecosystems is crucial for forest management to slow the rate of climate change. Here, we explored fine-scale biomass spatial patterns in a secondary warm temperate deciduous broad-leaved forest in north China. A 20-ha plot was established and classified by topographic features into ridge, valley, gentle slope, and steep slope habitats. Total tree biomass varied from 103.8 Mg/ha on the gentle slope habitats to 117.4 Mg/ha on the ridge habitats, with an average biomass of 109.6 Mg/ha across the entire plot. A few species produced the majority of the biomass, with five species contributing 78.4% of the total tree biomass. These five species included Quercus mongolica Fisch. ex Ledeb (41.7 Mg/ha, 38.1%), Betula dahurica Pall. (19.8 Mg/ha, 18.0%), Acer mono Maxim. (12.6 Mg/ha, 11.5%), Betula platyphylla Suk. (7.0 Mg/ha, 6.4%), and Populus davidiana Dode. (4.8 Mg/ha, 4.4%). The five species were also associated with certain habitats; for example, Q. mongolica was positively associated with the ridge habitat and A. mono was positively associated with the valley habitat. Results from this work document the variability in forest biomass across a warm temperate forest ecosystem of north China, with implications for managing and accounting forest carbon.
Evaluating the International Competitiveness of Vietnam Wood Processing Industry by Combining the Variation Coefficient and the Entropy Method
Authors: Vu Thi Thanh Huyen , Tian Gang , Khan Naveed , Zada Muhammad , Zhang Bin , Nguyen Thanh Van
Published: October 2019

Indicators measuring industrial international competitiveness are being continuously improved. However, so far, there is no unified perfect indicator to measure the level of international competitiveness of the industry. Based on the market share index (MS), trade competitiveness index (TC), revealed comparative advantage index (RCA), and relative trade advantage index (RTA), we constructed a comprehensive international competitiveness index by combining the variation coefficient and the entropy method. This study aims to compare and evaluate the international competitiveness of the wood processing industry (ICWPI) in Vietnam using a comprehensive international competitiveness index. The data is collected from the top 22 countries and the total import and export volume of the wood processing industry from the repository of official international trade statistics (UN Comtrade) database for 2001–2017. The results found that it is more accurate to use the combined variation coefficient and the entropy method to evaluate the international competitiveness of the wood processing industry, compared to using only a single index. The growth rate of international competitiveness of Vietnam increased rapidly from 2001 to 2007 but slowed from 2008 to 2017. Vietnam has the advantages of natural resources, low labor costs and favorable geographical location. However, the low productivity gains and added industry value have led to a gradual decline in the international competitiveness growth rate of Vietnam’s wood processing industry.
Consumption of Atlantic Salmon Smolt by Striped Bass: A Review of the Predator-Prey Encounter Literature and Implications for the Design of Effective Sampling Strategies
Authors: Andrews Samuel , Hirtle Sarah , Linnansaari Tommi , Curry R.
Published: October 2019

The native striped bass (Morone saxatilis) population of the Miramichi River, New Brunswick is undergoing an unprecedented recovery while Atlantic salmon (Salmo salar) numbers within that system continue to decline. Atlantic salmon smolt depart from the Miramichi system during the striped bass spawning period and it is hypothesized that elevated striped bass abundances will increase encounter rates and predation on smolts. We summarize all available striped bass diet studies occurring within the native range of Atlantic salmon and present a review of the feeding behavior and diet preferences of striped bass before, during, and after their spawning period. The key studies vary in methodologies and interpretability. We present a standardized approach for assessing striped bass predation threats and smolt vulnerability and thus an improved understanding of the species interactions to guide future management in the Miramichi River.
On the Collective Choice among Models of Social Protection: An Experimental Study
Authors: Farina Francesco , Ottone Stefania , Ponzano Ferruccio
Published: October 2019

A real-effort experiment is conducted in order to detect preferences for one out of three different models of the Welfare State characterized by different tax-and-transfer schemes. We reproduce a small society in the lab where: Subjects are grouped in three stylized classes (the rich, the middle class and the poor) on the basis of their performance in a real-effort activity; income and risk are assigned according to the class; tax revenue is spent to refund unlucky people and to provide a public good. Experimental subjects must choose (both under and without a veil of ignorance concerning their position in the society created in the lab) among (a) a baseline proportional scheme, where the State is neutral with respect to risk heterogeneity; (b) an actuarially fair scheme where low ability and low earnings subjects bear full individual responsibility for risk exposure and (c) a progressive scheme where mutual risk insurance spreads risk across all subjects such that low ability and low earnings individuals are compensated. Our most relevant finding is that preference is motivated less by a justice principle and more by self-interested considerations on the expectations surrounding one’s own position in the society.
Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy
Authors: Urbina-Jara Laura Keren , Rojas-Martinez Augusto , Martinez-Ledesma Emmanuel , Aguilar Dione , Villarreal-Garza Cynthia , Ortiz-Lopez Rocio
Published: October 2019

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes are present in about 50% of cases of hereditary breast cancer. Proteins encoded by these genes are key players in DNA repair by homologous recombination (HR). Advances in next generation sequencing and gene panels for breast cancer testing have generated a large amount of data on gene variants implicated in hereditary breast cancer, particularly in genes such as PALB2, ATM, CHEK2, RAD51, MSH2, and BARD1. These genes are involved in DNA repair. Most of these variants have been reported for Caucasian, Jewish, and Asian population, with few reports for other communities, like those in Latin American (LA) countries. We reviewed 81 studies from 11 LA countries published between 2000 and 2019 but most of these studies focused on BRCA1/2 genes. In addition to these genes, breast cancer-related variants have been reported for PALB2, ATM, CHEK2, BARD1, MLH1, BRIP1, MSH2, NBN, MSH6, and PMS2 genes. Some of these variants are unique to LA populations. This analysis may contribute to enhance breast cancer variant characterization, and thus to find therapies and implement precision medicine for LA communities.
A Double-Edged Sword: Aneuploidy is a Prevalent Strategy in Fungal Adaptation
Authors: Tsai Hung-Ji , Nelliat Anjali
Published: October 2019

Aneuploidy, a deviation from a balanced genome by either gain or loss of chromosomes, is generally associated with impaired fitness and developmental defects in eukaryotic organisms. While the general physiological impact of aneuploidy remains largely elusive, many phenotypes associated with aneuploidy link to a common theme of stress adaptation. Here, we review previously identified mechanisms and observations related to aneuploidy, focusing on the highly diverse eukaryotes, fungi. Fungi, which have conquered virtually all environments, including several hostile ecological niches, exhibit widespread aneuploidy and employ it as an adaptive strategy under severe stress. Gambling with the balance between genome plasticity and stability has its cost and in fact, most aneuploidies have fitness defects. How can this fitness defect be reconciled with the prevalence of aneuploidy in fungi? It is likely that the fitness cost of the extra chromosomes is outweighed by the advantage they confer under life-threatening stresses. In fact, once the selective pressures are withdrawn, aneuploidy is often lost and replaced by less drastic mutations that possibly incur a lower fitness cost. We discuss representative examples across hostile environments, including medically and industrially relevant cases, to highlight potential adaptive mechanisms in aneuploid yeast.
Transcriptome-Based SNP Discovery and Validation in the Hybrid Zone of the Neotropical Annual Fish Genus Austrolebias
Authors: García Graciela , Ríos Néstor , Gutiérrez Verónica , Serra Sebastián , Loureiro Marcelo
Published: October 2019

The genus Austrolebias (Cyprinodontiformes: Rivulidae) represents a specious group of taxa following annual life cycles in the neotropical ichthyofauna. They live in temporary ponds and each generation must be completed in a few months, depending on environmental stochasticity. Annual fish survive the dry season through diapausing eggs buried in the substrate of these ponds. A hypothesized bimodal hybrid zone between two taxa of the genus, A. charrua and A. reicherti from Dos Patos Merin lagoon system, was recently proposed based on genetics and morphological analyses. However, hundreds of additional nuclear molecular markers should be used to strongly support this hypothesized bimodal pattern. In the present paper, we conducted RNA-seq-based sequencing of the transcriptomes from pools of individuals of A. charrua, A. reicherti and their putative natural hybrids from the previously characterized hybrid zone. As a result, we identified a set of 111,725 SNP (single nucleotide polymorphism) markers, representing presumably fixed allelic differences among the two species. The present study provided the first panel of 106 SNP markers as a single diagnostic multiplex assay and validated their capacity to reconstruct the patterns of the hybrid zone between both taxa. These nuclear markers combined with Cytb gene and morphological analyses detected a population structure in which some groups among the hybrid swarms showed different level of introgression towards one or the other parental species according to their geographic distribution. High-quality transcriptomes and a large set of gene-linked SNPs should greatly facilitate functional and population genomics studies in the hybrid zone of these endangered species.
Comparison of Earthquake-Triggered Landslide Inventories: A Case Study of the 2015 Gorkha Earthquake, Nepal
Authors: Meena Sansar Raj , Tavakkoli Piralilou Sepideh
Published: October 2019

Despite landslide inventories being compiled throughout the world every year at different scales, limited efforts have been made to critically compare them using various techniques or by different investigators. Event-based landslide inventories indicate the location, distribution, and detected boundaries of landslides caused by a single event, such as an earthquake or a rainstorm. Event-based landslide inventories are essential for landslide susceptibility mapping, hazard modeling, and further management of risk mitigation. In Nepal, there were several attempts to map landslides in detail after the Gorkha earthquake. Particularly after the main event on 25 April 2015, researchers around the world mapped the landslides induced by this earthquake. In this research, we compared four of these published inventories qualitatively and quantitatively using different techniques. Two principal methodologies, namely the cartographical degree of matching and frequency area distribution (FAD), were optimized and applied to evaluate inventory maps. We also showed the impact of using satellite imagery with different spatial resolutions on the landslide inventory generation by analyzing matches and mismatches between the inventories. The results of our work give an overview of the impact of methodology selection and outline the limitations and advantages of different remote sensing and mapping techniques for landslide inventorying.
Expression Profiling of Candidate Genes in Sugar Beet Leaves Treated with Leonardite-Based Biostimulant
Authors: Hajizadeh Hanifeh Seyed , Heidari Bahram , Bertoldo Giovanni , Della Lucia Maria Cristina , Magro Francesco , Broccanello Chiara , Baglieri Andrea , Puglisi Ivana , Squartini Andrea , Campagna Giovanni , Concheri Giuseppe , Nardi Serenella , Stevanato Piergiorgio
Published: October 2019

Leonardite-based biostimulants are a large class of compounds, including humic acid substances. Foliar application of biostimulants at field level improves plant growth, yield and quality through metabolic changes and stimulation of plant proton pumps. The present study aimed at identifying optimum dosage of BLACKJAK, a humic acid-based substance, which is able to modify genes involved in sugar beet growth. Thirty-three genes belonging to various biochemical pathway categories were tested in leaves of treated sugar beet (Beta vulgaris L.) samples to assess gene expression profiling in response to BLACKJAK. Seedlings of a diploid and multigerm variety were grown in plastic pots and sprayed with two dilutions of BLACKJAK (dilution 1:500–1.0 mg C L−1 and dilution 1:1000–0.5 mg C L−1). Leaf samples were collected after 24, 48, and 72 h treatment with BLACKJAK for each dilution. RNA was extracted and the quantification of gene expression was performed while using an OpenArray platform. Results of analysis of variance demonstrated that, 15 genes out of a total of 33 genes tested with OpenArray qPCR were significantly affected by treatment and exposure time. Analysis for annotation of gene products and pathways revealed that genes belonging to the mitochondrial respiratory pathways, nitrogen and hormone metabolisms, and nutrient uptake were up-regulated in the BLACKJAK treated samples. Among the up-regulated genes, Bv_PHT2;1 and Bv_GLN1 expression exerted a 2-fold change in 1:1000 and 1:500 BLACKJAK concentrations. Overall, the gene expression data in the BLACKJAK treated leaves demonstrated the induction of plant growth–related genes that were contributed almost to amino acid and nitrogen metabolism, plant defense system, and plant growth.
Disentangling Physical Activity and Sedentary Behavior Patterns in Children with Low Motor Competence
Authors: Van Kann Dave H.H. , Adank Anoek M. , van Dijk Martin L. , Remmers Teun , Vos Steven B.
Published: October 2019

Children with low motor competence (MC) are at high-risk for physical inactivity, yet little is known about their physical activity (PA) and sedentary behavior (SB) patterns throughout the day. The purpose of this study is to disentangle PA and SB patterns among children with low MC across segmented day periods taking into account differences in gender and age. Data collection took place between May and July 2017. The Athletic Skills Track was used to measure MC. PA levels were objectively measured using accelerometers (ActiGraph, GT3X+) on school days. Data were segmented for (1) time before school, (2) time during school (based on school schedules), and (3) time after school. In total, data from 117 7-to-11 years-old children with low MC were eligible for analyses (N = 58 girls; N = 59 boys). Differences in moderate-to-vigorous PA (MVPA) and SB between segmented periods, gender, and grade were analyzed by ANOVAs with post hoc tests (Tukey) and Independent Sample T-tests respectively. Time spent at school is the major contributor of time spent in SB in children with low MC. Low MC is equally distributed among gender, but large differences exist among boys and girls in both MVPA and SB, indicating low-MC girls as most inactive group. This pattern is found in all segmented periods of the school day, i.e., before, during, and after school. This study stresses the negative contribution of current school curricula on PA and SB in children with low MC, indicating the most efficient period of the day to intervene. Future school-based PA and SB interventions should particularly focus on specific high-risk populations, i.e., children with low MC, and girls in particular.
Incidence of Cellulitis Following Acupuncture Treatments in Taiwan
Authors: Lin Shun-Ku , Liu Jui-Ming , Wang Pin-Hsuan , Hung Sheng-Ping , Hsu Ren-Jun , Chuang Heng-Chang , Lin Po-Hung
Published: October 2019

Background: Cellulitis is a complication of acupuncture, but the risk factors and annualized incidence remain unclear. Objective: This study analyzed the incidence and risk factors of cellulitis related to acupuncture in a cohort of one million participants derived from Taiwan’s Longitudinal Health Insurance Database. Methods: We tracked this cohort between 1997 and 2012 and recorded all outpatient medical information including diagnosis and treatment. Patients were categorized according to age, gender, comorbidities, residential area, and number of acupuncture treatments. We compared the incidence and risk of cellulitis between different demographics and comorbidities by logistic regression analysis and adjusted odds ratio (aOR) with a 95% confidence interval (95% CI). Results: We included 407,802 patients and 6,207,378 acupuncture treatments. The incidence of cellulitis after acupuncture was 64.4 per 100,000 courses of acupuncture treatment. The most common sites of cellulitis after acupuncture were the legs, feet, and face. Comorbidity was associated with post-acupuncture cellulitis; a multivariate logistic regression analysis showed that chronic kidney disease (aOR, 1.71; 95% CI, 1.55–1.88), rheumatoid arthritis (aOR, 1.86; 95% CI, 1.21–3.60), liver cirrhosis (aOR, 1.23; 95% CI, 1.15–1.32), diabetes mellitus (aOR, 1.69; 95% CI, 1.57–1.82), stroke (aOR, 1.44; 95% CI, 1.31–1.58), varicose veins (aOR, 2.38; 95% CI, 2.17–2.84), or heart failure (aOR, 1.81; 95% CI, 1.65–1.98) significantly increased cellulitis. Repeated exposure to acupuncture treatment was associated with an increased risk of cellulitis. Conclusions: A variety of chronic diseases may increase the risk of cellulitis after acupuncture. Physicians asked about past medical history before acupuncture might help to reduce cellulitis.
Radical Hysterectomy After Neoadjuvant Chemotherapy for Locally Bulky-Size Cervical Cancer: A Retrospective Comparative Analysis between the Robotic and Abdominal Approaches
Authors: Liu Chia-Hao , Lee Yu-Chieh , Lin Jeff Chien-Fu , Chan I-San , Lee Na-Rong , Chang Wen-Hsun , Liu Wei-Min , Wang Peng-Hui
Published: October 2019

Radical hysterectomy (RH) is the standard treatment for early stage cervical cancer, but the surgical approach for locally bulky-size cervical cancer (LBS-CC) is still unclear. We retrospectively compared the outcomes of women with LBS-CC treated with neoadjuvant chemotherapy (NACT) and subsequent RH between the robotic (R-RH) and abdominal approaches (A-RH). Between 2012 and 2014, 39 women with LBS-CC FIGO (International Federation of Gynecology and Obstetrics) stage IB2–IIB were treated with NACT-R-RH (n = 18) or NACT-A-RH (n = 21). Surgical parameters and prognosis were compared. Patient characteristics were not significantly different between the groups, but the NACT-R-RH group had significantly more patients with FIGO stage IIB disease, received multi-agent-based NACT, and had a lower percentage of deep stromal invasion than the NACT-A-RH group. After NACT-R-RH, surgical parameters were better, but survival outcomes, such as disease-free survival (DFS) and overall survival (OS), were significantly worse. On multivariate analysis, FIGO stage IIB contributed to worse DFS (p = 0.003) and worse OS (p = 0.012) in the NACT-A-RH group. Women with LBS-CC treated with NACT-R-RH have better perioperative outcomes but poorer survival outcomes compared with those treated with NACT-A-RH. Thus, patients with FIGO stage IIB LBS-CC disease might not be suitable for surgery after multi-agent-based NACT.
Methods in Experimental Work Break Research: A Scoping Review
Authors: Scholz André , Wendsche Johannes , Ghadiri Argang , Singh Usha , Peters Theo , Schneider Stefan
Published: October 2019

The number of studies on work breaks and the importance of this subject is growing rapidly, with research showing that work breaks increase employees’ wellbeing and performance and workplace safety. However, comparing the results of work break research is difficult since the study designs and methods are heterogeneous and there is no standard theoretical model for work breaks. Based on a systematic literature search, this scoping review included a total of 93 studies on experimental work break research conducted over the last 30 years. This scoping review provides a first structured evaluation regarding the underlying theoretical framework, the variables investigated, and the measurement methods applied. Studies using a combination of measurement methods from the categories “self-report measures,” “performance measures,” and “physiological measures” are most common and to be preferred in work break research. This overview supplies important information for ergonomics researchers allowing them to design work break studies with a more structured and stronger theory-based approach. A standard theoretical model for work breaks is needed in order to further increase the comparability of studies in the field of experimental work break research in the future.
Identifying Influential Nodes in Complex Networks Based on Local Effective Distance
Authors: Zhang Junkai , Wang Bin , Sheng Jinfang , Dai Jinying , Hu Jie , Chen Long
Published: October 2019

With the rapid development of Internet technology, the social network has gradually become an indispensable platform for users to release information, obtain information, and share information. Users are not only receivers of information, but also publishers and disseminators of information. How to select a certain number of users to use their influence to achieve the maximum dissemination of information has become a hot topic at home and abroad. Rapid and accurate identification of influential nodes in the network is of great practical significance, such as the rapid dissemination, suppression of social network information, and the smooth operation of the network. Therefore, from the perspective of improving computational accuracy and efficiency, we propose an influential node identification method based on effective distance, named KDEC. By quantifying the effective distance between nodes and combining the position of the node in the network and its local structure, the influence of the node in the network is obtained, which is used as an indicator to evaluate the influence of the node. Through experimental analysis of a lot of real-world networks, the results show that the method can quickly and accurately identify the influential nodes in the network, and is better than some classical algorithms and some recently proposed algorithms.
Amylose Inclusion Complexes as Emulsifiers for Garlic and Asafoetida Essential Oils for Mosquito Control
Authors: Muturi Ephantus J. , Hay William T. , Behle Robert W. , Selling Gordon W.
Published: October 2019

Although the insecticidal properties of some plant essential oils are well-documented, their use in integrated pest and vector management is complicated by their high volatility, low thermal stability, high sensitivity to oxidation, and low solubility in water. We investigated the use of bio-based N-1-hexadecylammonium chloride and sodium palmitate amylose inclusion complexes as emulsifiers for two essential oils, garlic and asafoetida, known to be highly toxic to mosquito larvae. Four emulsions of each essential oil based on amylose hexadecylammonium chloride and amylose sodium palmitate inclusion complexes were evaluated for their toxicity against Aedes aegypti L. larvae relative to bulk essential oils. All emulsions were significantly more toxic than the bulk essential oil with the lethal dosage ratios ranging from 1.09–1.30 relative to bulk essential oil. Droplet numbers ranged from 1.11 × 109 to 9.55 × 109 per mL and did not change significantly after a 6-month storage period. These findings demonstrated that amylose inclusion complexes enhanced the toxicity of essential oils and could be used to develop new essential oil based larvicides for use in integrated vector management.
Record of the Emerald Ash Borer (Agrilus planipennis) in Ukraine is Confirmed
Authors: Drogvalenko Alexander N. , Orlova-Bienkowskaja Marina J. , Bieńkowski Andrzej O.
Published: October 2019

Agrilus planipennis (Coleoptera: Buprestidae) is a devastating invasive pest of ash trees. This wood-boring insect is native to Asia and established in European Russia about 20 years ago. It severely damages Fraxinus pennsylvanica plantations and quickly spreads. In 2019 we first detected A. planipennis in Ukraine. More than 20 larvae were collected from under the bark of F. pennsylvanica trees on 5 September 2019 in the Markivka District of the Luhansk Region. The coordinates of the localities of collection were 49.614991 N, 39.559743 E; 49.614160 N, 39.572402 E; and 49.597043 N, 39.561811 E. The photos of the damaged trees with larval galleries, exit holes and larvae are presented. It indicates that A. planipennis is established in the east of Ukraine. This fact is important for development of quarantine protocols to prevent or at least slow the further spread of this invasive pest in Europe.
Identification of Regulatory Host Genes Involved in Sigma Virus Replication Using RNAi Knockdown in Drosophila
Authors: Liao Jen-Fu , Wu Carol-P , Tang Cheng-Kang , Tsai Chi-Wei , Rouhová Lenka , Wu Yueh-Lung
Published: October 2019

The Drosophila melanogaster sigma virus, a member of the Rhabdoviridae family, specifically propagates itself in D. melanogaster. It contains six genes in the order of 3′-N–P–X–M–G–L-5′. The sigma virus is the only arthropod-specific virus of the Rhabdoviridae family. Sigma-virus-infected Drosophila may suffer from irreversible paralysis when exposed to a high CO2 concentration, but generally, no other symptoms are reported. A recent study reported that host gene expression in immune pathways was not changed in sigma-virus-infected Drosophila, which does not necessarily suggest that they are not involved in virus–host interactions. The present study aimed to identify host genes associated with sigma virus replication. Immune pathways JAK-STAT and IMD were selected for detailed study. The results showed that the genome copy number of the sigma virus increased after knocking down the immune pathway genes domeless and PGRP-LC in Drosophila S2 cells. The knocking down of domeless and PGRP-LC significantly up-regulated the expression of the L gene compared to the other viral genes. We propose that the immune pathways respond to sigma virus infection by altering L expression, hence suppressing viral replication. This effect was further tested in vivo, when D. melanogaster individuals injected with dsdome and dsPGRP-LC showed not only an increase in sigma virus copy number, but also a reduced survival rate when treated with CO2. Our study proved that host immunity influences viral replication, even in persistent infection. Knocking down the key components of the immune process deactivates immune controls, thus facilitating viral expression and replication. We propose that the immunity system of D. melanogaster regulates the replication of the sigma virus by affecting the L gene expression. Studies have shown minimal host–virus interaction in persistent infection. However, our study demonstrated that the immunity continued to affect viral replication even in persistent infection because knocking down the key components of the immune process disabled the relevant immune controls and facilitated viral expression and replication.
Capabilities of Terahertz Cyclotron and Undulator Radiation from Short Ultrarelativistic Electron Bunches
Authors: Bratman Vladimir , Lurie Yuri , Oparina Yuliya , Savilov Andrey
Published: October 2019

Mechanisms of coherent spontaneous cyclotron and undulator radiations of short dense bunches, in which electrons move along the same stationary helical trajectories, but have different dynamic properties, have been compared in detail. The results are based on the simplest 1D model in the form of a plane consisting of uniformly distributed synchronously moving and in-phase emitting particles, as well as numerical 3D codes developed to study the dynamics of bunches in waveguides taking into account the effects of the radiation and spatial charge fields. For cyclotron radiation under group synchronism conditions, the Coulomb expansion of a bunch occurs along the surface of a constant wave phase with the formation of an effectively radiating coherent structure. A significantly higher radiation frequency, but with a lower efficiency, can be obtained in the regime of simultaneous excitation of high-frequency (autoresonant) and low-frequency waves; in the field of the latter, stabilization of the bunch phase size can be achieved. Such a two-wave generation is much more efficient when the bunches radiate in the combined undulator and strong guiding magnetic fields under conditions of the negative mass instability, when both the Coulomb interaction of the particles and the radiation field stabilize the longitudinal size of the bunch.
Flywheel vs. Supercapacitor as Wayside Energy Storage for Electric Rail Transit Systems
Authors: Khodaparastan Mahdiyeh , Mohamed Ahmed
Published: October 2019

Energy storage technologies are developing rapidly, and their application in different industrial sectors is increasing considerably. Electric rail transit systems use energy storage for different applications, including peak demand reduction, voltage regulation, and energy saving through recuperating regenerative braking energy. In this paper, a comprehensive review of supercapacitors and flywheels is presented. Both are compared based on their general characteristics and performances, with a focus on their roles in electric transit systems when used for energy saving, peak demand reduction, and voltage regulation. A cost analysis is also included to provide initial guidelines on the selection of the appropriate technology for a given transit system.
Mitochondrial DNA Mutations and Rheumatic Heart Diseases
Authors: Wade Fatou Balla , Sall Marie Parsine , Mbaye Fatimata , Sembene Mbacké
Published: October 2019

Acute rheumatic fever (ARF) is an autoimmune disease affecting the heart-valve endocardium in its final stage. Although rare in developing countries, ARF persists in third-world countries, particularly Senegal, where rheumatic heart diseases (RHDs) are the most common pediatric cardiovascular pathology. This study aimed to investigate mutations in MT-CYB in ARF and RHD in Senegalese patients. MT-CYB was amplified from blood samples from ARF patients at the Clinical of Thoracic and Cardiovascular Surgery of Fann National University Hospital Centre, Dakar, Senegal (control group, healthy individuals) and sequenced. More than half of the MT-CYB mutations (58.23%) were heteroplasmic. Transitions (61.67%) were more frequent than transversions (38.33%), and non-synonymous substitutions represented 38.33% of mutations. Unoperated RHD patients harbored frequent MT-CYB polymorphisms (7.14 ± 14.70 mutations per sample) and accounted for 72.73% of mutations. Paradoxically, subjects undergoing valvular replacement harbored infrequent polymorphisms (1.39 ± 2.97 mutations per patient) and lacked 36 mutations present in unoperated subjects. A genetic differentiation was observed between these two populations, and the mutations in operated subjects were neutral, while those in unoperated subjects were under positive selection. These results indicate a narrow link (perhaps even causal) between MT-CYB mutations and ARF and its complications (i.e., RHDs) and that these mutations are largely deleterious.
Prediction Models for Distortions and Residual Stresses in Thermoset Polymer Laminates: An Overview
Authors: Abouhamzeh Morteza , Sinke Jos , Benedictus Rinze
Published: October 2019

This paper reviews predictive models developed for the development of residual stresses and shape distortions during the manufacturing of thermoset polymeric/composite materials. Different sources that produce residual stresses and shape changes in the laminated panels are described and reviewed. An overview is presented on the characterisation and predictions of the phenomena resulting in residual stresses. The focus will be on the models accounting for the parameters during the cure cycle of the thermoset composite materials published in the literature from 2005 until 2018. The material types covered here range from thermoset adhesives, full composites, and fibre metal laminates. Furthermore, selected works are reviewed on the reduction of the shape changes and residual stresses of composites and fibre metal laminates consisting of thermoset polymers.
Antifungal Drugs: Special Problems Treating Central Nervous System Infections
Authors: Ashley Elizabeth Dodds
Published: October 2019

Treating fungal infections in the central nervous system (CNS) remains a challenge despite the availability of new antifungal agents. Therapy is limited by poor understanding of the kinetic properties of antifungal drugs in the CNS compounded by lack of data for many agents. In some cases, clinical response rates do not correspond to data on drug concentrations in the cerebral spinal fluid and/or brain parenchyma. In order to better characterize the use of antifungal agents in treating CNS infections, a review of the essential principles of neuroPK are reviewed. Specific data regarding antifungal drug concentrations in the cerebral spinal fluid and brain tissue are described from human data where available. Alternative dosing regimens and the role of antifungal drug concentration monitoring in treating fungal infections in the CNS are also discussed. Having a better understanding of these key concepts will help guide clinicians in determining the best treatment courses for patients with these devastating infections.
Current-Induced Changes of Surface Morphology in Printed Ag Thin Wires
Authors: Sun Quan , Lu Yebo , Tang Chengli , Song Haijun , Li Chao , Zuo Chuncheng
Published: October 2019

Current-induced changes of surface morphology in printed Ag thin wires were investigated by current stressing tests and numerical simulation. The samples were printed Ag thin wires on a flexible substrate with input and output pads. Different experimentalresults were obtainedthroughchangingthe current density after current supply and the mechanism of those phenomena were investigated by numerical simulations based on the method of atomic flux divergence. Good agreement between the simulations and experimental results was reached. It was found that electromigration was the main factor that caused the change of the surface morphology. The contribution of thermal migration can be ignored, and the Joule heating lead by the supplied current had a very significant accelerating effect on electromigration. Guidelines for effectively changing the Ag thin wire surface through providing predetermined current density was proposed, which were expected to be useful for improving the electrical reliability and lifetime of printed Ag thin wires in flexible electronic devices.
Thin Slabs Made of High-Performance Steel Fibre-Reinforced Cementitious Composite: Mechanical Behaviour, Statistical Analysis and Microstructural Investigation
Authors: Soares Junior Paulo Roberto Ribeiro , Maciel Priscila Souza , Barreto Richard Rodrigues , Silva Neto João Trajano da , Siqueira Corrêa Elaine Carballo , Bezerra Augusto Cesar da Silva
Published: October 2019

The present study evaluated the mechanical behaviour of thin high-performance cementitious composite slabs reinforced with short steel fibres. For this purpose, slabs with 1%, 3% and 5% vol. of steel fibres were moulded using the slurry infiltration method. Fibres concentrated in the region subjected to traction during bending stresses. After curing for 28 days, all slabs underwent flexural testing. The slabs with 5% fibre showed significantly higher flexural strength, deflection and toughness compared to those of the control group without reinforcement. The dense fibre distribution, resulting from the production process, led to profiles with multiple random cracks in the region of failure of the slabs as the fibre content increased. The results of the statistical analysis showed the intensity of the correlation between the variables and revealed that the increase of the fibre content significantly influenced the parameters of mechanical behaviour (load, flexural strength, deflection, toughness and toughness factor). Images obtained by optical microscopy aided in understanding the fibre–matrix interface, showing the bonding surface between the constituents of the composite.
Correlation between Microstructural Alteration, Mechanical Properties and Manufacturability after Cryogenic Treatment: A Review
Authors: Razavykia Abbas , Delprete Cristiana , Baldissera Paolo
Published: October 2019

Cryogenic treatment is a supplemental structural and mechanical properties refinement process to conventional heat treatment processes, quenching, and tempering. Cryogenic treatment encourages the improvement of material properties and durability by means of microstructural alteration comprising phase transfer, particle size, and distribution. These effects are almost permanent and irreversible; furthermore, cryogenic treatment is recognized as an eco-friendly, nontoxic, and nonexplosive process. In addition, to encourage the application of sustainable techniques in mechanical and manufacturing engineering and to improve productivity in current competitive markets, cryo-treatment can be considered as a promising process. However, while improvements in the properties of materials after cryogenic treatment are discussed by the majority of reported studies, the correlation between microstructural alteration and mechanical properties are unclear, and sometimes the conducted investigations are contradictory with each other. These contradictions provide different approaches to perform and combine cryogenic treatment with pre-and post-processing. The present literature survey, mainly focused on the last decade, is aimed to address the effects of cryogenic treatment on microstructural alteration and to correlate these changes with mechanical property variations as a consequence of cryo-processing. The conclusion of the current review discusses the development and outlines the trends for the future research in this field.