bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant
Authors: Correia Alexandra , Alves Pedro , Fróis-Martins Ricardo , Teixeira Luzia , Vilanova Manuel
Published: June 2022

Neospora caninum is an obligate intracellular protozoan responsible for abortion and stillbirths in cattle. We previously developed a mucosal vaccination approach using N. caninum membrane proteins and CpG adjuvant that conferred long-term protection against neosporosis in mice. Here, we have extended this approach by alternatively using the carbomer-based adjuvant Carbigen™ in the immunizing preparation. Immunized mice presented higher proportions and numbers of memory CD4+ and CD8+ T cells. Stimulation of spleen, lungs and liver leukocytes with parasite antigens induced a marked production of IFN-γ and IL-17A and, less markedly, IL-4. This balanced response was also evident in that both parasite-specific IgG1 and IgG2c were raised by immunization, together with specific intestinal IgA. Upon intraperitoneal infection with N. caninum, immunized mice presented lower parasitic burdens than sham-immunized controls. In the infected immunized mice, memory CD4+ T cells predominantly expressed T-bet and RORγt, and CD8+ T cells expressing T-bet were found increased. While spleen, lungs and liver leukocytes of both immunized and sham-immunized infected animals produced high amounts of IFN-γ, only the cells from immunized mice responded with high IL-17A production. Since in cattle both IFN-γ and IL-17A have been associated with protective mechanisms against N. caninum infection, the elicited cytokine profile obtained using CarbigenTM as adjuvant indicates that it could be worth exploring for bovine neosporosis vaccination.
Immunological Study of Combined Administration of SARS-CoV-2 DNA Vaccine and Inactivated Vaccine
Authors: Meng Ziyan , Ma Danjing , Duan Suqin , Zhang Jingjing , Yue Rong , Li Xinghang , Gao Yang , Li Xueqi , Zeng Fengyuan , Xu Xiangxiong , Jiang Guorun , Liao Yun , Fan Shengtao , Niu Zhenye , Li Dandan , Yu Li , Zhao Heng , Xu Xingli , Wang Lichun , Zhang Ying , Liu Longding , Li Qihan
Published: June 2022

Objective: We constructed two DNA vaccines containing the receptor-binding domain (RBD) genes of multiple SARS-CoV-2 variants and used them in combination with inactivated vaccines in a variety of different protocols to explore potential novel immunization strategies against SARS-CoV-2 variants. Methods: Two DNA vaccine candidates with different signal peptides (namely, secreted and membrane signal peptides) and RBD protein genes of different SARS-CoV-2 strains (Wuhan-Hu-1, B.1.351, B.1.617.2, C.37) were used. Four different combinations of DNA and inactivated vaccines were tested, namely, Group A: three doses of DNA vaccine; B: three doses of DNA vaccine and one dose of inactivated vaccine; C: two doses of inactivated vaccine and one dose of DNA vaccine; and D: coadministration of DNA and inactivated vaccines in two doses. Subgroups were grouped according to the signal peptide used (subgroup 1 contained secreted signal peptides, and subgroup 2 contained membrane signal peptides). The in vitro expression of the DNA vaccines, the humoral and cellular immunity responses of the immunized mice, the immune cell population changes in local lymph nodes, and proinflammatory cytokine levels in serum samples were evaluated. Results: The antibody responses and cellular immunity in Group A were weak for all SARS-CoV-2 strains; for Group B, there was a great enhancement of neutralizing antibody (Nab) titers against the B.1.617.2 variant strain. Group C showed a significant increase in antibody responses (NAb titers against the Wuhan-Hu-1 strain were 768 and 1154 for Group C1 and Group C2, respectively, versus 576) and cellular immune responses, especially for variant B.1.617.2 (3240 (p < 0.001) and 2430 (p < 0.05) for Group C1 and Group C2, versus 450); Group D showed an improvement in immunogenicity. Group C induced higher levels of multiple cytokines. Conclusion: The DNA vaccine candidates we constructed, administered as boosters, could enhance the humoral and cellular immune responses of inactivated vaccines against COVID-19, especially for B.1.617.2.
The Role of Healthcare Providers in Promoting Human Papillomavirus Vaccines among Men Who Have Sex with Men: A Scoping Review
Authors: Chin Kok-Yong , Ekeuku Sophia Ogechi , Hamzah Muhammad Rafie
Published: June 2022

Background: The uptake of human papillomavirus vaccines (HPVV) among men who have sex with men (MSM) remains unsatisfactory. Healthcare providers play a crucial role in improving HPVV acceptability and uptake among MSM. This scoping review aims to provide an overview of (1) the perceived role of healthcare providers by MSM, and (2) the knowledge, beliefs and practices of healthcare providers themselves in promoting HPVV uptake. Methods: A literature search was performed with PubMed and Scopus databases using a specific search string. The relevant original research articles on this topic were identified, and the major findings were charted and discussed. Results: The literature search identified 18 studies on the perceived role of healthcare providers by MSM, and 6 studies on the knowledge, beliefs and practices of healthcare providers in promoting HPVV uptake among MSM. Recommendations by healthcare providers and disclosure of sexual orientation were important positive predictors of higher HPVV acceptability and uptake. Sexual healthcare providers were more confident in delivering HPVV to MSM clients compared to primary practitioners. Conclusion: Recommendation from, and disclosure of sexual orientation to healthcare providers are important in promoting HPVV uptake among MSM. The competency of healthcare providers in delivering HPVV to MSM can be improved by having clearer guidelines, education campaigns and better incentives.
Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination
Authors: Kimura Motoya , Niwa Jun-Ichi , Doyu Manabu
Published: June 2022

Rhabdomyolysis is a well-known clinical syndrome of muscle injury. Rhabdomyolysis following coronavirus disease 2019 (COVID-19) vaccination has recently been reported. The patients’ weakness gradually subsided and did not recur. Rhabdomyolysis associated with COVID-19 vaccination has not been assessed by repeated magnetic resonance imaging (MRI) within a short time. We report a rare case of an older woman who developed recurring weakness with rhabdomyolysis after COVID-19 vaccination. A 76-year-old woman presented with myalgia 2 days after receiving a third dose of the COVID-19 vaccine. A physical examination showed weakness of the bilateral iliopsoas muscles. Her creatine kinase concentration was 9816 U/L. MRI showed hyperintensity of multiple limb muscles. She was treated with intravenous normal saline. Her symptoms disappeared within 3 days. However, MRI on day 4 of hospitalization showed exacerbation of the hyperintensity in the left upper limb muscles. On day 5 of hospitalization, weakness of the left supraspinatus and deltoid muscles appeared. MRI on day 8 of hospitalization showed attenuation of the hyperintensity in all muscles. Her weakness and elevated creatine kinase concentration disappeared by day 10. Repeated MRI over a short time may be useful to predict potential weakness and monitor the course of COVID-19 vaccine-induced rhabdomyolysis.
Antibody- and T Cell-Dependent Responses Elicited by a SARS-CoV-2 Adenoviral-Based Vaccine in a Socially Vulnerable Cohort of Elderly Individuals
Authors: Moya Martin , Marrama Marcela , Dorazio Carina , Veigas Florencia , Manselle Cocco Montana N. , Dalotto Moreno Tomas , Rabinovich Gabriel A. , Aleksandroff Ariel
Published: June 2022

Background: In spite of compelling evidence demonstrating safety and immunogenicity of adenoviral-based SARS-CoV-2 vaccines in the general population, its effects in socially vulnerable elderly individuals are poorly understood. Here we aimed to investigate the efficacy of two doses of combined vector vaccine, the Gam-COVID-Vac (Sputnik-V vaccine), at 14, 42, and 180 days after immunization, in a nursing home for underprivileged population and homeless individuals. Methods: A phase 3, open-label clinical trial involving administration of two adenoviral vectors (Ad26-Ad5) vaccine, in elderly individuals over the ages of 60 years was performed. SARS-CoV-2 Spike RBD-specific IgG antibodies at days 21-, 42- and 180 post-vaccination was analyzed in sera of individuals receiving two doses of the Sputnik-V vaccine with an interval of 21 days. SARS-CoV-2-specific CD8+ T cell responses, measured by intracellular tumor necrosis factor (TNF) was determined by flow cytometry following antigen-specific cultures. Results: A total of 72 elderly adults with a mean age of 72.6 ± 9.5 years-old was selected after applying the inclusion criteria, all corresponding to an underprivileged population. Two-doses vaccination with Sputnik-V vaccine elicited an antibody-mediated immune response (revealed by quantitative detection of SARS-CoV-2-specific IgG antibodies, CMIA) 70% at day 21, 90% at day 42, and 66.1% at day 180. Fully vaccinated individuals had robust SARS-CoV-2-specific T cell responses, evidenced by TNF production in CD4+ and CD8+ T cells in all time periods analyzed. Conclusion: Six months after receipt of the second dose of the Gam-COVID-Vac vaccine, SARS-CoV-2-specific IgG levels declined substantially among the tested population, whereas CD4+ and CD8+ T-cell-mediated immunity remained at high levels. These data suggest that two doses of combined adenoviral-based vaccine elicits a considerable level of SARS-CoV-2 immune responses in elderly individuals, highlighting its safety and immunogenicity in this highly vulnerable population.
Sputnik V Effectiveness against Hospitalization with COVID-19 during Omicron Dominance
Authors: Shkoda Andrey S. , Gushchin Vladimir A. , Ogarkova Darya A. , Stavitskaya Svetlana V. , Orlova Olga E. , Kuznetsova Nadezhda A. , Keruntu Elena N. , Pochtovyi Andrei A. , Pukhov Alexander V. , Kleymenov Denis A. , Krzhanovsky Vasyli G. , Vasina Daria V. , Shkuratova Nataliya V. , Shidlovskaya Elena V. , Gorbunov Alexey L. , Kustova Daria D. , Mazurina Evgeniya A. , Kozlova Sofya R. , Soboleva Alexandra V. , Grigoriev Igor V. , Pankratyeva Lyudmila L. , Odintsova Alina S. , Belyaeva Elizaveta D. , Bessonova Arina A. , Vasilchenko Lyudmila A. , Lupu Igor P. , Adgamov Ruslan R. , Tkachuk Artem P. , Tokarskaya Elizaveta A. , Logunov Denis Y. , Gintsburg Alexander L.
Published: June 2022

Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave of COVID-19 has been ongoing since the end of 2021. It is caused by a virus variant B.1.1.529, also known as “Omicron” and its descendants. The effectiveness of major vaccines against Omicron is not known. The purpose of this study is to evaluate the efficacy of the Sputnik V vaccine. The main goal is to assess its protection against hospitalization in the period of Omicron dominance. We conducted our study based on a large clinical center in Moscow (Russia) where 1112 patients were included. We used the case-population method to perform the calculations. The data we obtained indicate that the Omicron variant causes at least 90% of infections in the studied cohort. The effectiveness of protection against hospitalization with COVID-19 in our study was 85.9% (95% CI 83.0–88.0%) for those who received more than one dose. It was 87.6% (95% CI 85.4–89.5%) and 97.0% (95% CI 95.9–97.8%) for those who received more than two or three doses. The effectiveness in cases of more severe forms was higher than for less severe ones. Thus, present study indicates the high protective efficacy of vaccination against hospitalization with COVID-19 in case of Omicron lineage.
Increasing Uptake of COVID-19 Vaccination and Reducing Health Inequalities in Patients on Renal Replacement Therapy—Experience from a Single Tertiary Centre
Authors: Poulikakos Dimitrios , Chinnadurai Rajkumar , Anwar Saira , Ahmed Amnah , Chukwu Chukwuma , Moore Jayne , Hayes Emma , Gorton Julie , Lewis David , Donne Rosie , Lamerton Elizabeth , Middleton Rachel , O’Riordan Edmond
Published: June 2022

Background: COVID-19 vaccination has changed the landscape of the COVID-19 pandemic; however, decreased uptake due to vaccine hesitancy has been observed, particularly in patients from minority ethnic backgrounds and socially deprived areas. These patient characteristics are common in patients on Renal Replacement Therapy (RRT), a population at extremely high risk of developing serious illness from COVID-19 and who would thus benefit the most from the vaccination programme. We designed a bespoke COVID-19 vaccination programme for our RRT population with the aim of decreasing health inequalities and increasing vaccination uptake. Methods: Key interventions included addressing vaccine hesitancy by deploying the respective clinical teams as trusted messengers, prompt eligible patient identification and notification, the deployment of resources to optimise vaccine administration in a manner convenient to patients, and the timely collection and analysis of local safety and efficacy data. First, COVID-19 vaccination data in relation to ethnicity and social deprivation in our RRT population, measured by the multiple deprivation index, were analysed and compared to uptake data in the total regional adult clinically extremely vulnerable (CEV) population in Greater Manchester (GM). Univariate logistic regression analysis was used to explore the factors associated with not receiving a vaccine. Results: Out of 1156 RRT patients included in this analysis, 96.7% received the first dose of the vaccination compared to 93% in the cohort of CEV patients in the GM. Age, gender, ethnicity, and a lower index of multiple deprivation were not identified as significant risk factors for poor first dose vaccine uptake in our cohort. Vaccine uptake in Asian and Black RRT patients was 94.9% and 92.3%, respectively, compared to 93% and 76.2% for the same ethnic groups in the reference CEV GM. Vaccine uptake was 96.1% for RRT patients in the lowest quartile of the multiple deprivation index, compared to 90.5% in the GM reference population. Conclusion: Bespoke COVID-19 vaccination programmes based on local clinical teams as trusted messengers can improve negative attitudes towards vaccination and reduce health inequalities.
Path Planning and Guidance Laws of a Formula Student Driverless Car
Authors: Santos Solange D. R. , Azinheira José Raul , Botto Miguel Ayala , Valério Duarte
Published: June 2022

Autonomous driving has been a topic of great interest in several areas, of which motor racing is no exception. The aim of this work is the autonomous control of the future Formula Student Lisboa vehicle, by implementing different strategies for control and path planning, with the purpose of minimising race lap times. These strategies are tested in simulation, using a realistic model of the prototype. The approach followed involves the decoupling of the lateral and longitudinal subsystems and obtaining the reference path using artificial potential fields, combined with a two-pass algorithm developed to generate a speed profile. In this way, a sub-optimal solution is reached that adequately portrays the expected behaviour of a human driver while respecting traction conditions. The process of generating the speed reference requires prior knowledge of the track layout. This assumption is then eased for obstacle avoidance, i.e., for a scenario where, in addition to the track limits, unknown static obstacles are present. A decoupled control approach is followed controlling each of the two subsystems individually.
Evaluation of a Back-up Range Extender and Other Heavy-Duty BEV-Supporting Systems
Authors: Zander Lennarth , Svens Pontus , Svärd Henrik , Dahlander Petter
Published: June 2022

Electric powertrains in terms of battery electric vehicles (BEV) are considered to be very interesting for heavy truck transportations. The challenge is the need for very large onboard energy and batteries. Long-term fuel cells (FCs) are considered an interesting support system for heavy-duty BEV, but in the short term, a range extender (REX) is also interesting. A heavy-duty BEV with 970 kWh batteries installed can handle 27% of all possible missions for the Scania fleet considering daily recharging. The back-up range extender (BUREX) can expand this figure to 55% utilized 20 days per year. If a customer has a few very energy-demanding use cases each year and does not want to pay for all the batteries needed, the BUREX may be an especially good option. The BUREX reduces life-cycle CO2 emissions, irrespective of the generation mix of the grid supplying the electricity used in vehicle manufacturing and battery charging. The BUREX reuse of the existing electric components of the BEV powertrain enables the installation of a 10% larger battery pack while being 80% less costly. The BUREX also adds redundancy to the BEV concept while recharging infrastructure improves, especially in rural places. These results indicate that the BUREX concept is a powerful short-term solution that could enable greater use of HD FC and BEV trucks while charging infrastructure and FC technologies gradually become more mature.
Epidemiological Monitoring of COVID-19 in a Brazilian City: The Interface between the Economic Policies, Commercial Behavior, and Pandemic Control
Authors: de Brito Veronica Perius , Carrijo Alice Mirane Malta , Martins Marcos Vinicius Teixeira , de Oliveira Stefan Vilges
Published: June 2022

The new Coronavirus disease (COVID-19) pandemic was responsible for one of the worst public health crises in Brazil, which led to the implementation of economic policies to keep social distance. Our aim is to perform an epidemiological analysis of the COVID-19 pandemic in Uberlândia, Minas Gerais, in 2021, highlighting the impact of government commercial policies on pandemic control. This is an epidemiological, observational, and analytical study with secondary data. We constructed a regression for count data using the Poisson model. Data adherence to the regression was verified by Cameron & Trivedi and the Likelihood Ratio tests. According to the Poisson model, there was a statistically significant association (p < 0.001) between the adoption of rigid commercial interventions and the drop in deaths. Moreover, we revealed a consistency between the economic policies and the number of screening tests applied, which may have contributed to the deaths behavior. This study shows the importance of institutionalizing economic policies and their positive impacts on pandemic control; however, it raises the discussion about the serious repercussions of these measures on population vulnerability.
A Variety of Leptospira Serovar Distribution in Bullfighting Cattle in Southern of Thailand
Authors: Ngasaman Ruttayaporn , Chanchayanon Baramee , Kaewnoi Domechai , Kamyingkird Ketsarin
Published: June 2022

Bullfighting cattle are selected from domestic cattle (Bos indicus) that demonstrate good performance in Thai bullfighting without a matador [...]
ИСТОРИКО-КУЛЬТУРНЫЕ ОСОБЕННОСТИ КЫРГЫЗОВ КИТАЙСКОЙ НАРОДНОЙ РЕСПУБЛИКИ
Authors: Алиев К.
Published: June 2022

В статье рассматривается историко-культурная специфика кыргызов, как одного из национальных меньшинств Китайской Народной Республики. Материалы основаны главным образом на китайских, российских, кыргызских источниках, охватывающих значительный период с древности по настоящее время. Основное внимание уделялось районам компактного проживания кыргызов в Синьцзяне – Кызылсу-Кыргызском автономном округе. Несмотря на общность культуры, языка, традиций и осознание самоидентичности кыргызского народа, у кыргызов Китая имеется и ряд особенностей в историко-культурном аспектах. Китай превратился в мощный полюс мировой экономики и теперь нацеливается на лидерство в мировой политике, обусловленные глобальными планами Пекина. Кыргызстан имеет обширную границу с Китаем и этнические кыргызы исторически проживают на территории соседнего государства. В этом контексте, изучение истории и культуры кыргызов КНР все более становится актуальной.
Бул макалада Кытай Эл Республикасынын аз улуттарынын бири катары кыргыздардын тарыхый жана маданий өзгөчөлүктөрүн көрсөтүү. Материалдар негизинен кытай, орус, кыргыз булактарына таянып, байыркы доордон азыркы учурга чейинки олуттуу мезгилди камтыган. Негизги көңүл Синьцзяндагы кыргыздар компакттуу жашаган аймактарга – Кызылсуу-Кыргыз автономиялуу областына бурулган. Кыргыз элинин маданиятынын, тилинин, каада-салттарынын жана өзүн-өзү таануусунун жалпылыгына карабастан, кытайлык кыргыздар да тарыхый-маданий аспектиде бир катар өзгөчөлүктөргө ээ. Кытай дүйнөлүк экономиканын кубаттуу уюлуна айланды жана Пекиндин глобалдык пландарынан улам азыр дүйнөлүк саясатта лидерликке умтулууда. Кыргызстан Кытай менен кеңири чек арага ээ жана кыргыздар тарых улап коңшу мамлекеттин аймагында жашашат. Мындай шартта Кытайдагы кыргыз элинин тарыхын жана маданиятын изилдөө актуалдуу болуп барат.
The purpose of this article is to show the historical and cultural specifics of the Kyrgyz, as one of the national minorities of the People’s Republic of China. The materials are based mainly on Chinese, Russian, Kyrgyz sources, covering a significant period from antiquity to the present. The main attention was paid to the areas of compact residence of the Kyrgyz in Xinjiang - the Kyzylsu-Kyrgyz Autonomous prefecture. Despite the commonality of culture, language, traditions and awareness of the self-identity of the Kyrgyz people, the Kyrgyz of China also have a number of features in the historical and cultural aspects. China has become a powerful pole of the world economy and is now aiming for leadership in world politics, due to Beijing’s global plans. Kyrgyzstan has an extensive border with China and ethnic Kyrgyz historically live in the territory of the neighboring state. In this context, the study of the history and culture of the Kyrgyz people of China is becoming increasingly relevant.
ЭКСПЛИКАЦИЯ ЭТНОКУЛЬТУРНЫХ ЦЕННОСТЕЙ В РУССКОМ И КЫРГЫЗСКОМ ГЕНДЕРНОМ КОММУНИКАТИВНОМ ПОВЕДЕНИИ
Authors: Камбаралиева У. , Стернин И.
Published: June 2022

Статья посвящена контрастивной характеристике национально-специфических особенностей
коммуникативного поведения представителей русской, кыргызской лингвокультуры с позиции типологии организационных культур Г. Хофстеда. Человеческое общение впервые обозначено термином «коммуникативное поведение» И.А.Стерниным (1989 г). «Гендер» - комплекс понятий, появившийся под влиянием постструктурализма, фемининистской лингвистики и образующий научное направление - «гендерные исследования». Термин раньше использовался для характеристики различных аспектов «женских» проблем в сравнении с «мужскими». Выявлено, что маскулинность, феминининность рассматриваются как категории, присутствующие в каждой лингвокультуре и влияющие на формирование этнокультурных ценностей. Они имеют разные степени выраженности и представлены в качестве подразумеваемых нормативных стереотипов, поскольку в одной и той же лингвокультуре обнаруживаются феминининные и маскулинные признаки.
Макала орус, кыргыз лингвомаданиятынын өкүлдөрүнүн коммуникациялык жүрүм-турумунун өзгөчөлүктөрүн Герт Хофстеддин уюмдук маданияттар типологиясынын өӊүтүнөн контрасттык мүнөздөөгө арналды. Адамдын баарлашуусу «коммуникациялык жүрүм-турум» термини менен (1989-ж. И.А.Стернин тарабынан) аталган. «Гендер» - постструктурализм менен фемининисттик лингвистиканын таасиринен пайда болгон жана «гендердик изилдөөлөр» аталышындагы илимий багытты түзгөн түшүнүктөрдүн комплексин камтыйт. Алгач термин «аялдардын» жана «эркектердин проблемаларынын» ар кандай аспектилерин салыштыруу үчүн пайдаланылган. Маскулиндүүлүк, феминининдүүлүк ар бир лингвомаданиятта орун алган, этномаданий баалуулуктардын калыптанышына таасир эткен категориялар катары каралары ачыкталды. Аталган категориялар лингвомаданияттын типтерине байланыштуу ар кандай даражада байкалып, алар коомдо алдын ала белгилүү ченемдик стереотиптер катары көрсөтүлөт, анткени бир лингвомаданияттан феминининдик, маскулиндик белгилер табылышы мүмкүн.
The article is devoted to the contrastive characterization of the national-specific features of the communicative behavior of representatives of the Russian, Kyrgyz linguoculture from the standpoint of the typology of organizational cultures of G. Hofstede. Human communication was first designated by the term "communicative behavior" by I.A. Sternin (1989). "Gender" is a set of concepts that appeared under the influence of poststructuralism, feminist linguistics and forms a scientific direction - "gender studies". The term was previously used to characterize various aspects of "female" problems in comparison with "male" ones. It is revealed that masculinity and femininity are considered as categories present in every linguistic culture and influencing the formation of ethno-cultural values. They have different degrees of expression and are presented as implied normative stereotypes, since feminine and masculine signs are found in the same linguistic culture.
УПРАВЛЕНЧЕСКИЙ АНАЛИЗ КОНСАЛТИНГОВЫХ УСЛУГ КАК ЭЛЕМЕНТ ИНФРАСТРУКТУРЫ ПРОФЕССИОНАЛЬНОЙ ПОДДЕРЖКИ БИЗНЕСА
Authors: Молдошева А. , Савин В.
Published: June 2022

Успех современных бизнес структур зависит во многом от их возможности адаптироваться под постоянно меняющиеся условия внутренней и внешней среды. Не каждая компания или предприниматель обладают необходимым набором знаний и соответствующих компетенций, чтобы справиться с возникающими проблемами. Одним из методов решения данного вопроса является привлечение консалтинговых компаний, имеющих достаточный интеллектуальный потенциал и опыт необходимый в решении управленческих задач по организации бизнес-процессов предприятия. Задачи являются достаточно сложными и комплексными, потому что изменение экономических условий, обусловленных конкурентной борьбой, схожесть новых игроков определяют потребность в разработке корпоративных стандартов, модернизацию финансового учета и планирования, анализ финансово-экономических показателей, составление и адаптацию таких бизнес-планов, которые обеспечат бесперебойную работу организации и достижение оптимального уровня доходности.
Заманбап бизнес-түзүмдөрдүн ийгилиги көбүнчө алардын ар кандай факторлор менен шартталган ички жана тышкы чөйрөнүн тынымсыз өзгөрүп туруучу шарттарына ыңгайлашуу жөндөмдүүлүгүнөн көз каранды. Ар бир компания же ишкер пайда болгон көйгөйлөр менен күрөшүү үчүн керектүү билимге жана тиешелүү компетенцияга ээ эмес. Бул маселени чечүүнүн ыкмаларынын бири ишкананын бизнес-процесстерин уюштуруу үчүн башкаруу милдеттерин чечүүдө зарыл болгон жетиштүү интеллектуалдык потенциалы жана тиешелүү тажрыйбасы бар консалтингдик компанияларды тартуу болуп саналат. Айтылган милдеттер кыйла татаал жана татаал, анткени атаандаштыктан улам өзгөргөн экономикалык шарттар, жаңы оюнчулардын окшоштугу корпоративдик стандарттарды иштеп чыгуу, финансылык эсепти жана пландаштырууну модернизациялоо, финансылык-экономикалык көрсөткүчтөрдү талдоо, мындай бизнес-пландарды түзүү жана ылайыкташтыруу зарылчылыгын аныктайт. бул уюмдун үзгүлтүксүз иштешин жана рентабелдүүлүктүн оптималдуу деңгээлине жетишүүнү камсыз кылат.
The success of modern business structures depends largely on their ability to adapt to the constantly changing conditions of the internal and external environment caused by various factors, which to one degree or another with a certain degree of frequency arise depending on the phase of the organization’s life cycle. Not every company or entrepreneur has the necessary set of knowledge and relevant competencies to cope with emerging problems. The tasks voiced are quite complex and complex, because the changing economic conditions caused by competition, the similarity of new players determine the need to develop corporate standards, modernize financial accounting and planning, analyze financial and economic
ДИНАМИКА И СТРУКТУРА ЭКСПОРТА И ИМПОРТА ВО ВНЕШНЕТОРГОВОМ ОБОРОТЕ КЫРГЫЗСКОЙ РЕСПУБЛИКИ С КИТАЕМ
Authors: Сманова А.
Published: June 2022

В данной статье автор рассматривает проблему глоболизации, которая коснулась и экономики Кыргызстана. Автор статьи акцентирует внимание на внешнеторговых отношениях Кыргызстана и Китая. На сегодняшний день Кыргызстан в системе международного сотрудничества, являясь небольшой страной, имеет свои преимущества в богатстве природных ресурсов, которые являются большим потенциалом для агропромышленности. Следует отметить такие природные ресурсы Кыргызстана как водные, являющиеся двигателями гидроэнергетики. Наша страна имеет огромные запасы золоторождения, которые используются в сфере металлургии и обрабатывающей промышленности Кыргызской Республики. Автор считает, что эти сферы все еще нуждаются в улучшении, так как модернизация сферы обрабатывающей промышленности даст возможность нашей стране конкурировать с другими странами мира.
Бүгүнкү күндө Кыргызстан эл аралык кызматташтык системасында чакан өлкө болуу менен агроөнөр жай үчүн чоң потенциалга ээ болгон жаратылыш ресурстарынын байлыгы боюнча өзүнүн артыкчылыктарына ээ. Кыргызстандын гидроэнергетикасынын кыймылдаткычы болгон суу сыяктуу жаратылыш ресурстарын белгилей кетүү керек, биздин өлкөдө алтындын эбегейсиз запастары бар, алар металлургия тармагында колдонулат, Кыргыз Республикасынын кайра иштетүү өнөр жайы дагы эле өркүндөтүлүшү керек. . Өндүрүш өнөр жайын өркүндөтүү менен өлкөбүз башка мамлекеттер менен атаандаша алат. Бул макалада бүгүнкү күндө дүйнө глобалдашуу процесстерине жана бизнести эл аралык деңгээлде киргизүүгө чоң көңүл буруп жаткан учурда эмнелер талкууланат. Бул макалада эки өлкөнүн, Кыргызстан менен Кытайдын тышкы соода мамилелери каралат.
Today Kyrgyzstan in the system of international cooperation, being a small country, has its own advantages in the richness of natural resources, which are of great potential for the agro-industry. It should be noted such natural resources of Kyrgyzstan as water, which are the engines of hydropower, our country has huge reserves of gold of birth, which are used in the field of metallurgy, the processing industry of the Kyrgyz Republic still needs to be improved. By improving the manufacturing industry, our country will be able to compete with other countries. This article discusses what today, when the world pays great attention to the processes of globalization and the introduction of business at the international level. This article examines the foreign trade relations of the two countries, Kyrgyzstan and China.
Circuitos alternativos de comercialización en pandemia. Actores, dispositivos y procesos de adaptación. El caso de La Plata (Argentina)1
Authors: Fernández Lisandro , Clara Craviotti
Published: June 2022

El presente artículo se propone identificar y analizar la dinámica de los circuitos alternativos de comercialización (CAC) de la agricultura familiar hortícola, durante el aislamiento por pandemia de COVID-19, en el partido de La Plata. En primer lugar, se caracterizan las diferentes experiencias seleccionadas en base al tipo de estructura organizacional que las sustentan. En segundo lugar, se analizan sus dispositivos y procesos de adaptación, para culminar con el planteo de algunas reflexiones acerca de las condiciones y posibilidades para la continuidad de los CAC.

 

 

 

 

 

1 El presente artículo se inscribe en el PICT (2019-02650) “La construcción de circuitos alimentarios alternativos (CAA): Actores sociales y dispositivos".
Represión, género y sexualidad: abordajes para la historia reciente en Sudamérica
Authors: D´Antonio Débora
Published: June 2022

Más de tres décadas de un interés constante e inalterado de amplios sectores de la sociedad civil por esclarecer lo sucedido durante los años de las dictaduras de seguridad nacional en el Cono Sur, resultó ser el impulso más destacado e importante para profundizar el conocimiento y renovar las preguntas sobre esos fenómenos históricos. Contribuyó, además, con ello, sobre todo en los casos de Argentina y Chile, el desarrollo de juicios por delitos de lesa humanidad en los que se desplegaron sistemáticamente nuevas líneas de indagación que permitieron conocer en mejor grado los mecanismos de estructuración y de funcionamiento de los aparatos represivos de los Estados dictatoriales. Fue en este marco que las investigaciones abocadas al pasado reciente desde las Ciencias Sociales y Humanas produjeron diversos hallazgos interpretativos. Los mismos pueden identificarse en la multiplicación de los objetos de estudio, en su reencuadre a partir de las escalas de análisis locales y transnacionales que han dejado al descubierto coordinaciones represivas bilaterales y regionales, por ejemplo, en el ajuste de las metodologías para comprender ese “pasado que no pasa” o en la reconsideración de las periodizaciones en las que se sitúan a los autoritarismos en procesos históricos de más larga duración y en los que se busca enhebrar continuidades y rupturas.
“Las hijas del trueno”. Algunas notas sobre el carácter sexuado de la represión en Mendoza (1976)
Authors: Rodríguez Agüero Laura ´
Published: June 2022

Este trabajo se propone ahondar en las características sexo genéricas y de clase de los dispositivos represivos estatales que actuaron en Mendoza durante 1976. En esa dirección, en primer lugar analizaremos ciertas especificidades que tuvieron las prácticas represivas cuando las víctimas fueron mujeres que estuvieron secuestradas en los CCD D2 y Casino de Suboficiales. En segundo lugar estudiaremos el accionar específico de las policías y el Ejército en las dinámicas represivas en clave sexo genérica, y en tercer lugar intentaremos abordar el carácter de clase –en articulación con el de género- de ciertos dispositivos represivos que actuaron en la provincia durante el primer año de la dictadura. También realizaremos una breve descripción de las prácticas de solidaridad desarrolladas por mujeres en los espacios de encierro analizados.Los interrogantes planteados serán abordados partiendo de la idea de que el combate a la denominada “subversión” estuvo inscripto en la relación asimétrica entre los géneros sexuales, hecho que se plasmó en el carácter diferenciado de la represión hacia varones y mujeres por parte de los dispositivos represivos tanto estatales como paraestatales.
Crónicas de la barbarie. Categorías y formas de organización de la política nativa chaqueña, analizadas y narradas por la Compañía de Jesús
Authors: Cargnel Josefina G. , Paz Carlos D.
Published: June 2022

La barbarie fue una importante figura en la retórica misional jesuítica, desde ella se construyó la imagen de un buen salvaje “domesticado” que moraba en las fronteras y en espacios reduccionales, que pueden ser concebidos como civitas. El objetivo de este trabajo es realizar un aporte al conocimiento de la historiografía jesuítica, del siglo XVIII, ponderando la figura de la barbarie que se hace presente en la literatura ignaciana, centrados en la lectura de dos obras La Descripción Chorographica del Gran Chaco Gualamba [1733] de Pedro Lozano, SJ y la Historia de los Abipones [1783] de Martín Dobrizhoffer, SJ; partiendo de la base que estos dos escritos marcan un jalón dentro de la literatura jesuítica.
Procesos de especialización económica en la porción central de Tandilia durante la segunda mitad del siglo XVIII: el caso de las parcialidades pampas-serranas
Authors: Dátola Carla
Published: June 2022

A partir de la colonización del continente americano por parte de la Corona española, las sociedades indígenas vieron trastocada su identidad étnica. Ello se debió a que se dinamizaron los procesos de cambio en torno a la etnicidad y territorialidad indígena. Para el caso de las parcialidades pampa-serranas del sur y suroeste bonaerense, estas venían atravesando desde tiempos pre-hispánicos una serie de cambios internos, en torno a su dieta, herramientas, modo de vida, etc., que incluso se nutrieron de los vínculos entablados con diversos grupos étnicos de un lado y otro del cordón cordillerano andino y que luego se potenciaron en el marco de la Araucanización de las Pampas.La introducción de especies animales europeas, pautas de consumo, hábitos y la participación en los circuitos mercantiles del mundo occidental lejos de ser un obstáculo para el desarrollo de los grupos nativos de las Pampas, se volvió un factor crucial para la emergencia de un núcleo pastoril indígena articulado a los mercados transcordilleranos y a la frontera bonaerense. Este se convertiría en una expresión de las relaciones interétnicas entabladas con los hispanocriollos y a la vez en un desafío a la hora de competir por los recursos.
La construcción de la identidad nacional palestina
Authors: Martinelli Martín
Published: June 2022

En el presente artículo analizaremos las narrativas contrastantes de la identidad palestina que podemos ubicar entre el terreno religioso: judío, cristiano y musulmán; y el ámbito nacionalista: palestina e israelí. Estas dos últimas se imbricaron a través de sus historiografías y sus mitos fundacionales. Por un lado, el nacionalismo palestino afrontó impedimentos inusitados a los que respondió con diversas formas de resistencia. Por otra, el estado israelí ejerció la dominación a través del lenguaje puesto que modificó el nombre de muchos lugares con el fin de hebraizar la toponimia palestina.Por último, la dominación a través del nombramiento y del lenguaje resultó central en este proceso. En el nombramiento, hallamos el objetivo de ocultar a los “otros”, de subordinarlos a la dominación israelí. La erradicación de los nombres fue acompañada por una expropiación de la memoria territorial. Desde la narrativa israelí a partir de 1967, Cisjordania pasó a designarse en la documentación oficial de Israel como Judea y Samaria. Mientras tanto, emplearon el término “árabe” para disociar a los palestinos de su identidad, según el contexto los llamaron: “refugiados árabes”, “árabes de Israel” o “árabes de los Territorios”.
Acromegalia
Authors:   , Escaray Oscar Pedro
Published: June 2022

Sumario: Hipófisis - Anatomia - Embriologia - Histologia - Biologia - Fisiologia Caso clinico Acromegalia
Tamamlanmamış Bir Modernleşme Projesi Olarak Mersin
Authors: DÖNMEZ Benan
Published: June 2022

Modernleşme, temas ettiği noktada 'yıkımlar' ile 'olanaklar'ı eş zamanlı olarak meşrulaştıran döngüsel bir zemindir. Mimarlık üzerinden mekanı ve kenti etkilediği halinde ise, karşılıklı bir başkalaşım eylemi üzerinden dinamik bir süreci tetikleyici konumuyla anlam kazanır. Çalışma da, bir 19. yüzyıl kenti üzerinden modernleşmenin anlamını keşfetmeye girişirken, doğrudan modernitenin kendisinin kurduğu bir kent olarak Mersin'i ele almaktadır. Kentleşme süreci üzerinden bir anlatının gerçekleştirildiği noktada ise, tartışmanın merkezine 'doğa' kavramı konumlandırılmakta, modernleşmenin uzantısında 'doğa'nın dönüşen anlamı bir argüman olarak sorunsallaştırılmaktadır. 19. yüzyıl içerisinde, gündelik hayatın dinamikleri ile kendiliğinden (serüvenci) bir modernleşme gösteren süreçteki kentleşme yaklaşımlarının ve doğanın gücünün keşfedilerek 'birlikte gelişme' üzerine kurulu anlamının, 20. yüzyıl ve sonrasında kaybolarak yerini planlı (rutin) bir modernleşme süreciyle birlikte doğanın ele geçirilmesi, temsili hale indirgenmesi ve tüketilmesi üzerine kurulu anlamına devretmesi üzerinden bir tartışma görünür kılınmaktadır. Dolayısıyla, mevcut durumundaki çıkmazlarıyla Mersin kenti "tamamlanmamış bir modernleşme projesi" olarak görülmekte, geleceğe dair inanç ve vaadini, geçmişinin dinamikleriyle yüzleşerek onları anlama aracılığıyla oluşturmaya niyetlenmektedir.
Retiro de elementos de osteosíntesis en trauma maxilofacial
Authors: Pedemonte Christian , Bravo Maximiliano , Yañez Nicolás , Vargas Ilich , González Edgardo
Published: June 2022

Objetivo: Analizar la prevalencia y los factores en la remoción de elementos de osteosíntesis (OTS) de pacientes tratados quirúrgicamente debido a fracturas maxilofaciales.Materiales y métodos: Estudio retrospectivo descriptivo, donde fueron incluidos todos los pacientes con diagnóstico de fractura maxilofacial y tratados mediante reducción abierta y fijación interna rígida en un intervalo de 10 años, en el Servicio de Cirugía Oral y Maxilofacial en el Hospital Clínico Mutual de Seguridad.Resultados: En un total de 807 pacientes intervenidos, con un rango etario entre 22-66 años, fueron utilizados 2421 OTS. Entre ellos, 58 pacientes (7,2%) fueron sometidos a un segundo procedimiento quirúrgico, retirándose un total de 129 OTS (5,3%). La principal causa de retiro de OTS fue infección (41,1%), comúnmente de carácter tardío. El tercio inferior facial fue el más afectado, específicamente, la zona parasinfisiaria. El 39% fue retirado antes de los 12 meses de posicionados.Conclusiones: El retiro de OTS posterior a trauma maxilofacial tiene una baja prevalencia, el sitio más afectado es el hueso mandibular y la mayoría se retira dentro de los primeros 12-24 meses. La etiología es variable, sin embargo, la infección se mantiene como una de las principales. Los hallazgos sugieren que no sería recomendable realizar este procedimiento de forma universal para todos los pacientes.
Ordinal Pattern-Based Dissimilarity Measure for Slow Cortical Potential Training in Stroke
Authors: Shi Wenbin , Zhang Chuting , Yeh Chien-Hung , Liu Heng
Published: June 2022

Biological signals, such as EEG and ECG, generate complex fluctuations in correspondence with the underlying system dynamics. In this study, we propose a dissimilarity quantification, which is an improvement of information-based similarity for capturing the features of underlying dynamics from positivity or negativity trials in the neurofeedback training of chronic stroke patients. Simulated Gaussian white and pink noises are used to evaluate the validity of this measure by different embedding dimensions, time delays, and data lengths. Then, the method is applied to slow cortical potentials of chronic stroke patients. The results imply that the proposed dissimilarity measure characterizes the unique dynamical patterns of SCP signals. The dissimilarity measure is capable of capturing the underlying dynamics of SCPs that belong to positivity or negativity trials. Besides, as the session progressed, the dissimilarity showed an increasing trend.
Effect of stoichiometry on the spin Hall angle of the half-Heusler alloy topological semimetal YPtBi
Authors: Shirokura Takanori , Kondo Tsuyoshi , Hai Pham Nam
Published: June 2022

We investigated the effect of stoichiometry on the spin Hall angle of the half-Heusler alloy topological semimetal YPtBi by changing the composition ratio r of Y/Pt from 0.5 to 1.9. We confirmed that YPtBi with high C1 ordering can be deposited by co-sputtering at r = 0.5–1.5, and a large effective spin Hall angle

θ

SH

eff

of 1.7 was achieved in a junction with Pt/Co/Pt at the exact stoichiometry r = 1.0. The

θ

SH

eff

–conductivity relationship is similar to that observed in samples with exact stoichiometry, indicating that the spin Hall effect in YPtBi is robust against the change of its stoichiometry.
Realization of flexible AlGaN/GaN HEMT by laser liftoff
Authors: Alam Md Didarul , Hussain Kamal , Mollah Shahab , Simin Grigory , Khan Asif , Chandrashekhar MVS
Published: June 2022

We demonstrate fully fabricated AlGaN/GaN high electron mobility transistors (HEMTs) transferred from sapphire to copper tape on flexible polyethylene terephthalate using 193 nm excimer laser liftoff (LLO). The heterojunction is structurally intact after LLO, leading to preserved electron mobility

μ

n

∼1630 cm2 V−1 s−1 and carrier concentration

n

s

∼1013 cm−2. The maximum drain saturation current decreased by ∼18% after transfer, which is a lower reduction than other reported transfer methods. The drain current of this flexible HEMT increased monotonically under tensile stress applied using a convex-shaped plate, while the threshold voltage shifted more negative in quantitative agreement with the expected piezoelectric charge for an intact heterojunction.
Characteristics of the great bustard (Otis tarda) (Otididae, Aves) habitats in the Trans-Volga region according to food availability during the chick rearing period
Authors: Oparina O. S. , Oparin M. L. , Kudryavtsev A. Yu. , Oparina A. M.
Published: June 2022

The results of our studies of potential nesting sites for bustards in the Saratov Trans-Volga region are presented. Characteristics of plant communities, as well as the quantitative and qualitative composition of arthropods in these areas, are given. Specific materials obtained in 2017–2021 at 6 plots are given, namely: crops of winter wheat, millet, and sunflower; fallows of various ages; and young (2nd stage) and old virgin lands. The obtained results are compared with the data of previous years. The obtained results on the state of the forage base of bustards allow us to conclude that loss of nesting habitats by birds of this species has actually occurred. Those areas, where, despite the decrease in the abundance of insects, there are still enough of them to feed the chicks, are not used by bustards as nesting stations. These are fallows of various ages and virgin lands. The lack of a sufficient number of arthropods necessary for feeding chicks in those places where bustards prefer to nest, namely, cereals crops, leads to catastrophic consequences for reproduction, and, consequently, the survival of the species. The numbers of large orthoptera and beetles in winter crops, reflecting biomass indicators, have decreased by 10 times compared to 2000, during the period of extensive agriculture. The intensification of agricultural production, the use of pesticides on various crops, as well as the change in the structure of crop rotation are the main causes for the insufficient food supply during the period of rearing chicks. The results obtained give grounds to believe that the number of bustards will continue to decline due to the inability to raise their offspring as a result of the lack of food supply.
Work Safety Risk Analysis Using Hirarc Method In Iron Production Area PT. Java Rakindo
Authors: Novtantino Bagas
Published: June 2022

HIRARC (Hazard Identification, Risk Assessment and Risk Control) is a series of processes to identify hazards that can occur in routine or non-routine activities in the company, then carry out a risk assessment of these hazards and then create a hazard control program so that the risk level can be minimized to a lower level. with the aim of preventing accidents. The implementation of K3 begins with good planning including, identification of hazards, assessment and risk control which are part of risk management. HIRARC is what determines the direction of K3 implementation in the company. This study aims to determine the risk analysis of occupational safety and health in the work production section of PT. Java Rakindo This type of research is a quantitative study using a descriptive approach. The population in this study were all workers in the work environment at PT. Java Rakindo with a total sampling technique that is as many as 25 respondents who are in the iron production section. The data were analyzed using univariate to describe the respondent's characteristics and to analyze each variable. K3 risk analysis using the HIRARC method obtained an assessment that the most dominant K3 hazard is substitution hazard of 72% (high). K3 risk assessment with a moderate level of risk category (Medium) of 84%. Administrative control of 92% and control of PPE by 100% so that it can be said that it has not been fully implemented (50%-90%).

 