bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA Expression Profiles Analysis in Sperm Reveals hsa-mir-191 is an Auspicious Omen of in Vitro Fertilization
Authors: Xu Hua , Wang Xin , Wang Zhikai , Li Jianhui , Xu Zhiming , Miao Maohua , Chen Guowu , Lei Xiangdong , Wu Jun , Shi Huijuan , Wang Ke , Zhang Tiancheng , Sun Xiaoxi
Published: November 2019

Background: MicroRNAs (miRNAs) are a class of noncoding small RNAs that play important roles in many physiological processes by regulating gene expression. Previous studies have shown that the expression levels of total miRNAs increase during mouse embryonic development, and some miRNAs control the regulatory network in development progression. However, few studies have focused on the effects of miRNAs on early human embryonic development. The relationship between miRNAs and early human embryogenesis is still unknown. Results: In this study, sperm samples from 102 patients with a normal sperm index but treated with assisted reproductive technology (ART) were collected for small RNA sequencing, and the relationships between differentially expressed small RNAs and the fertilization rate (FR), blastocyst rate and high-quality embryo rate (HQER) were analyzed. The sperm samples with high hsa-mir-191 expression had a higher FR, effective embryo rate (EER) and HQER. hsa-mir-191 was used as a single indicator to predict the HQER. The receiver operating characteristic (ROC) curve had an area under the ROC curve (AUC) of 0.686. We also found that hsa-mir-191 expression is correlated with an abnormal sperm rate (cor = 0.29, p< 0.01). We also evaluated the relationship between hsa-mir-34c and early human embryo development in these 102 sperm samples and obtained negative results. Conclusions: These findings suggest that high hsa-mir-191-5p expression in sperm is associated with early human embryonic quality and that hsa-mir-191-5p could be used as a potential marker to screen high-quality sperm to improve the success rates of in vitro fertilization (IVF). Keywords: miRNA, hsa-mir-191, hsa-mir-34c, RNA-Seq, Embryonic development
Association between the elevation of tumor-infiltrating lymphocytes in different subtypes of primary breast tumors and prognostic outcomes: A meta-analysis
Authors: He Lin , Wang Yaling , Wu Qian , Song Yuhua , Ma Xuezhen , Wang Haiji
Published: November 2019

Purpose To investigate the impact of the elevation of tumor-infiltrating lymphocytes (TILs) in different molecular subtypes of primary breast cancer, i.e. a 10% increment of TILs in tumor and lymphocyte-predominant breast cancer (LPBC), on long-term survival and pathological complete response (pCR) and to compare the presentation of high-level TILs across these molecular subtypes.Methods Citation retrieval was performed in the PubMed, Cochrane Library, Embase and Web of Science databases. All statistical calculations were performed by the software of StataSE version 12.0.Results Twenty-two eligible clinical trials including 15676 unique patients were included for meta-analysis. The 10% increment of TILs in human epidermal growth factor receptor 2 (HER2)-overexpression (pooled Hazard ratio (HR), 0.92; 95% CI, 0.89-0.95) and triple-negative (TN) (pooled HR, 0.90; 95% CI, 0.89-0.92) breast tumors significantly improved overall survival (OS) but in Luminal tumor subtype was inert to improve that (pooled HR, 1.06; 95% CI, 0.99-1.13). It was also associated with an increased pCR rate in breast cancers (pooled Odds ratio (OR), 1.27; 95% CI, 1.19-13.5). LPBC was significantly related with a higher pCR rate (OR, 2.73; 95% CI, 2.40-3.01) than non-LPBC. This significant difference was also shown in different molecular subtypes of LPBC compared with those of non-LPBC. HER2-amplified (OR, 3.14; 95% CI, 1.95-5.06) and TN (OR, 4.09; 95% CI, 2.71-6.19) phenotypes of breast cancers expressed significantly elevated high-level TILs than Luminal tumor subtype, although the presentation of those between the former two subsets was not significantly different (OR, 1.30; 95%CI, 0.83-2.04).Conclusion The elevation of TILs in breast tumors predicts promising prognostic outcomes, particularly in the HER2-overexpression and TN subtypes. These benefits in Luminal tumor subtype need to be warranted.
Understanding the meaning of conformity to feminine norms in lifestyle habits and health: A cluster analysis.
Authors: Esteban-Gonzalo Sara , Ho Petula Sik Ying , Aparicio-García Marta Evelia , Esteban-Gonzalo Laura
Published: November 2019

Background: Gender roles impact different spheres of life and lead women to behavioral patterns and lifestyle habits associated with femininity, generating important differences between men and women in health. The present study analyzed relationships between conformity to the feminine norms and different lifestyle indicators: educational level, marital status, alcohol consumption, tobacco consumption, sleeping hours, social support and physical activity. Additionally, cluster analysis was developed in order to identify different patterns of gender role conformity. Methods: The sample was made up of 347 women age 18-70 from Spain. Data collection was conducted during 2014. Results: Multiple logistic regression analyses produced odds ratios showing that women with lower feminine role conformity were more likely to use tobacco and alcohol, but less likely to share their lives with someone. Cluster analysis found four different profiles of gender role conformity, related to different patterns of alcohol consumption and marital status. Conclusions: Conformity to feminine norms was associated with basic affective conditions such as sharing life with others and with alcohol and tobacco consumption, but not with physical activity, social support and sleep duration. While tobacco and alcohol use has important health implications, public health systems should pay attention to gender related variables in order to design and implement specific prevention programs.
Estimating Optimal Dynamic Treatment Strategies Under Resource Constraints Using Dynamic Marginal Structural Models
Authors: Caniglia Ellen , Murray Eleanor , Hernan Miguel , Shahn Zach
Published: November 2019

Background: Existing methods for estimating the optimal treatment or monitoring strategy typically assume unlimited access to resources. However, when a health system has resource constraints, such as limited funds, access to medication, or monitoring capabilities, medical decisions must balance impacts on both individual and population health outcomes. That is, decisions should account for competition between individuals in resource usage. A simple solution is to estimate the (counterfactual) resource usage under the possible interventions and choose the optimal strategy for which resource usage is within acceptable limits. Methods: We propose a method to identify the optimal dynamic intervention strategy that leads to the best expected health outcome accounting for a health system's resource constraints. We then apply this method to determine the optimal dynamic monitoring strategy for people living with HIV when resource limits on monitoring exist using observational data from the HIV-CAUSAL Collaboration. In our example, we identify the optimal CD4 cell count at which to decrease monitoring frequency from every 3-6 months to every 9-12 months among the subset of strategies that satisfy a hypothetical constraint on monitoring. We find the resource constrained dynamic strategy (RCDS) that minimizes the risk of virologic failure given a hypothetical resource constraint where individuals can only be monitored on average every 6 months. Results: Given the hypothetical resource constraint, the optimal monitoring strategy is `monitor CD4 cell count and HIV-RNA every 3-6 months when CD4 is below 320 cells/ml and every 9-12 months when CD4 is above 320 cells/ml.' Conclusions: We describe and and apply a method to identify the optimal RCDS given a hypothetical resource constraint. Similar applications may be useful in settings with limited availability of or capacity for monitoring individuals living with HIV or other chronic diseases.
Height predict incident non-alcoholic fatty liver disease in a general adult population, independent of body mass index and metabolic syndrome
Authors: Kumari Shubham , Wang Xuena , Gu Yeqing , Huang Yuhan , Zhang Qing , Liu Li , Meng Ge , Wu Hongmei , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Wang Guolin , Song Kun , Niu Kaijun
Published: November 2019

Background Early-life hormonal and nutritional factors can greatly influence the risk of non-alcoholic fatty liver disease (NAFLD). Adult height is a simple marker for these factors. We aimed to evaluate adult height as a predictor of NAFLD.Methods We performed a prospective cohort study of 35, 994 participants recruited from 2010 to 2016 in Tianjin, China. NAFLD was diagnosed by ultrasound. Adjusted Cox proportional hazards regression models were conducted in 2019 to assess the gender-specific association between the quintiles of height and the incidence of NAFLD.Results Participants were followed up for 5.5 years with a mean follow-up of 2.6 years. During the follow-up period, 6,245 of 35,994 participants developed NAFLD. The multiple-adjusted hazard ratios (95% confidence interval) of NAFLD for increasing quintiles of height were 1.00 (reference), 0.90 (0.81, 0.99), 0.97 (0.87, 1.07), 0.86 (0.78, 0.96), and 0.84 (0.75, 0.94) ( P for trend < 0.01) in males and 1.00 (reference), 0.97 (0.86, 1.09), 0.98 (0.86, 1.11), 0.93 (0.81, 1.06), and 0.84 (0.73, 0.96) ( P for trend = 0.02) in females, respectively.Conclusions The study is the first to demonstrate adult height is a new, simple and inexpensive marker for ultra-early prediction of NAFLD.
Prevalence and causes of needlestick injuries among dental care providers: A systematic review and meta-analysis
Authors: Pournaghi-Azar Fatemeh , Mohseni Mohammad , Ghojazadeh Morteza , Derakhshani Naser , Azami-Aghdash Saber
Published: November 2019

Background The objective of this systematic review and meta-analysis was to identify the prevalence and causes of NeedleStick Injuries (NSI) among dental care providers.Methods Data collection was carried out through searching the following key words: needlestick injuries, percutaneous injuries, epidemiology, prevalence, occurrence, etiology, risk factors. The following databases were searched: Google Scholar, PubMed, Scopus, MagIran, Iranian Scientific Information Database (SID) and IranMedex. Moreover, some relevant journals and websites were searched manually and the reference lists of the selected articles were checked. In the final stage of the literature review, we searched the gray literature and contacted the experts whenever needed.Results From 765 articles reviewed, 31 cases were included in the study. In total, the needlestick injury history of 6,737 people (4,402 dentists, 1,000 Dental Health Care Workers (DHCWs) and 1,335 students) had been reported. The overall prevalence of NSI was 48% at an average of 11.1 months. About 69% of NSI cases were not reported. About 79% of the different groups of DHCWs had been vaccinated for the hepatitis B virus (HBV). The most important factors affecting the occurrence of NSI were categorized into two groups of individual factors (lapse in concentration, stress, lack of adequate trainings, and not using safety precautions) and patient-related factors (unexpected patient movements, anxious and uncooperative patients). The occurrence of NSI during treatment procedure (40.1 mean propotion), doing injections (34.2 mean propotion) and recapping (30 mean propotion) were the most important procedures causing NSI among dentists.Conclusion Results of the study show thatprevalence of NSI among DHCWs is high, incidence report of NSI is low and vaccination rate for prevention of bloodborne diseases is inadequate. In this regard it’s recommended to design and implemented comprehensive preventive measures to reduction of NSI prevalence, increase reporting of NSI and vaccination rate
NAC transcription factors in autopolyploid Saccharum spontaneum: genome-wide identification, expression pattern and a ‘Dry’ orthologous gene
Authors: Wang Hengbo , Wang Yongjun , Xiao Naiyan , Hua Xiuting , Zhang Muqing , Ming Ray , Zhang Jisen
Published: November 2019

Background: The NAC acronym originates from these three genes (NAM, ATA1/2 and CUC2), and were proved to participate in plant development, sugar accumulation and stress tolerance. However, little information is available regarding these genes in sugarcane. The newly published sugarcane genome provided an opportunity to identify the SsNAC transcription factors. Results: In this study, a total of 151 NAC genes including 327 alleles were identified in the autopolyploid S. spontaneum genome and were distributed unevenly on eight chromosomes with the majority located on Chr 5(54, 16.51%), Chr 1(51, 15.60%) and Chr 2(51, 15.60%). 71.6%(234) and 12.53%(41) of SsNAC genes were mainly derived from segmental duplication and tandem duplication. Phylogeny analysis of NAC TF proteins by comparing NAC between sugarcane and Arabidopsis thaliana suggested that the NAC family can be divided into 15 subgroups with one subgroup unclassified. RNA-seq data analysis revealed that 82 SsNAC were expressed in 15 segments of the developmental gradient of the leaf and 74 SsNAC were presented in 12 different developmental stages, respectively. Remarkably, SsNAC genes of the ATAF subgroup presented the highest expression levels among the subgroups, and seven of eight SsNAC genes from the ATAF subgroup excluding SsNAC30 were present at much higher expression levels in the developmental gradient of the leaf than those in different developmental tissues types, indicating that the ATAF subgroup may have significant roles and participate in leaf growth and development and photosynthesis. Importantly, the NAC1 subgroup SsNAC91 gene, being orthologous to Sobic.006G147400 ( Dry gene ), displayed significantly higher expression levels in premature and mature stems of the low sucrose and low water content species S. spontaneum as opposed to the orthologous gene in the high sugar and high water content species S. officinarum . This suggests that the SsNAC91 gene may also play important roles in cellulose biosynthesis and water transport in sugarcane as it does in sorghum. Conclusions: This study provided the basis for the comprehensive genomic study of the SsNAC gene family and thus established a good foundation for the functional analyses of SsNAC genes which can be utilized to breed new varieties of sugarcane.
Exposure Assessment To Inhalable And Respirable Dust In The Post-Earthquake Construction Sites In The City Of L’aquila
Authors: Mastrantonio Riccardo , Civisca Angela , Lippolis Tamara , Inglese Enrica , Siciliano Eugenio , Pompei Domenico , Cococcetta Lucio , Scatigna Maria , Fabiani Leila
Published: November 2019

Following an earthquake occurred in the middle Italy in 2009, the involved territory hosted in ten years thousands of construction sites. The aim of this study is to assess the chemical exposure of the construction workers involved in the reconstruction of the city. To assess the exposure we collected 91 air samples to quantify the occupational exposure to airborne dusts and free crystalline silica dusts.
Six construction companies joined the study and hosted the air sampling activities. We identified 4 work tasks: bricklayer and similar; scaffolder and carpenter; manual demolition; other tasks. Personal air sampling was performed by using the SKC AirCheck XR5000 sample pumps. Respirable dust and respirable crystalline silica dusts were collected by using a GS-3 Cyclones and 25 mm PVC filters; inhalable dust was collected by using a I.O.M. sampler and 25 mm PVC filters. The analyses were carried out by using gravimetric determination. Sampling time varied from 4 to 8 hours.
The geometric mean values of inhalable dust concentration for the work tasks was: 3,65 mg/m 3 for scaffolder and carpenter; 18,16 mg/m 3 for manual demolition workers; 8,76 mg/m 3 for bricklayer and similar; 6,33 mg/m 3 for other work tasks.
The geometric mean values of respirable dust concentration for the work tasks was: 0,67 mg/m 3 for scaffolder and carpenter; 0,92 mg/m 3 for manual demolition workers; 0,72 mg/m 3 for bricklayer and similar; 0,45 mg/m 3 for other work tasks.
About the Crystalline Free Silica dust exposure, the average concentration in mg/m 3 was: 0,0038 for manual demolition workers, 0,0057 for scaffolder and carpenter, 0,004 for bricklayer and similar, 0,0035 for other tasks.
The comparison of the results shows that manual demolition workers are exposed to considerably high levels of inhalable dusts, exceeding the ACGIH TLV-TWA limit of 10 mg/m 3 .
About the respirable dust concentration, none of the work tasks dust concentration exceeded the ACGIH TLV-TWA limit of 3 mg/m 3 .
Measurements of crystalline silica dust have shown levels below the threshold limit value of 0,025 mg/m 3 . This is in line with the average concentrations of respirable dust.
DEKRYMINALIZACJA POSIADANIA I UŻYWANIA NARKOTYKÓW WEDŁUG DOUGLASA HUSAKA. PERSPEKTYWA POLSKA
Authors: Wyciechowski-Kuchta Gniewomir
Published: November 2019

Artykuł przedstawia teorię kryminalizacji Douglasa Husaka, która aspiruje do bycia normatywnym miernikiem zasadności regulacji prawnokarnych. W przeglądzie dorobku naukowego i publicystycznego profesora Husaka ukazane jest, jak konkretyzuje się ona w przypadku zakazu posiadania i zażywania narkotyków. W drugiej części artykułu przedstawione są dokonania polskiej doktryny na tym polu oraz przeprowadzona jest analiza porównawcza teorii Husaka i polskiej nauki. Artykuł zwieńczony jest omówieniem wyroku Trybunału Konstytucyjnego dotyczącego kryminalizacji posiadania oraz uprawy marihuany w świetle postulatów amerykańskiego naukowca.
Physical Fitness and Long-term Blood Pressure Variability in Young Male Military Personnel
Authors: Lin Gen-Min , Tsai Kun-Zhe , Lin Chin-Sheng , Han Chih-Lu
Published: November 2019

Aims:

The aim of this study is to investigate the association of physical fitness with longterm
Blood Pressure Variability (BPV) in young male adults.

Methods:

1,112 healthy military males, aged 18-40 years (mean age, 32 years), in Taiwan were
included for the current analysis. Resting blood pressures were measured over the right upper arm
in a sitting position every two years from 2012 to 2018 (2012-14, 2014-15, 2015-16, 2016-18).
Long-term BPV by Standard Deviation (SDSBP and SDDBP) and Average Real Variability (ARVSBP
and ARVDBP) were assessed across 4 visits during the study period. Aerobic fitness was evaluated
by the time taken for a 3000-meter run test, and anaerobic fitness was evaluated by the number of
2-minute sit-ups and 2-minute push-ups.

Results:

After adjusting the systolic and diastolic blood pressure, the time for a 3000-meter run was
associated with ARVSBP, SDSBP, and SDDBP (β [SE]: 0.007 [0.002], 0.004 [0.002], and 0.005
[0.002], respectively, all p <0.05) but not with ARVDBP. In addition, the number of 2-minute sit-ups
was inversely associated with ARVSBP (β [SE]: -0.041 [0.017], p =0.01) but not with ARVDBP,
SDSBP, and SDDBP. There was no association of the number of 2-minute push-ups with the BPV
indexes. After additionally adjusting the age, body mass index, and other covariates, all the associations
were found to be not significant.

Conclusion:

It was found that there was no association of physical fitness with long-term BPV in
young male military personnel. Previous studies have shown no association with cardiorespiratory
fitness in the elderly. This study further increased the knowledge of a null association between anaerobic
fitness and long-term BPV.
Social Media Use in Cardiovascular Imaging
Authors: Parwani Purvi , Lee James , Khalique Omar K. , Bucciarelli-Ducci Chiara
Published: November 2019

:

Social Media is a rising influence in the global world of cardiovascular medicine, allowing
for a dynamic approach to physician education, research dissemination and collaborative discussion.
The visual nature of social media platforms, particularly Twitter, lends itself particularly
well to the tremendous advances and stunning visuals of cardiac imaging. The hashtag “#cardiotwitter”
provides around the clock, asynchronous, ubiquitous, free education. It allows connection
among cardiac imagers across the world to share ideas and discuss contemporary issues pertaining
to multimodality imaging. This review highlights the role of social media in advancing the practice
of cardiac imaging and provides guidance on gaining visibility in the social media imaging community.
Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH
Authors: de Carvalho Hayalla Corrêa , Ieque Andressa Lorena , Valverde Tamires Leite , Baldin Vanessa Pietrowski , Meneguello Jean Eduardo , Campanerut-Sá Paula Aline Zanetti , Vandresen Fábio , Ghiraldi Lopes Luciana Dias , Passos Souza Mariana Regina , Santos Nathally Claudiane de Souza , Dias Siqueira Vera Lucia , Caleffi-Ferracioli Katiany Rizzieri , Lima Scodro Regiane Bertin , Cardoso Rosilene Fressatti
Published: November 2019

Background:

For more than 60 years, the lack of new anti-tuberculosis drugs and the
increase of resistant Mycobacterium tuberculosis lineages exhibit a therapeutic challenge, demanding
new options for the treatment of resistant tuberculosis.

Objective:

Herein, we determined the (i) activities of (-)-camphene and its derivatives and (ii)
combinatory effect with pyrazinamide (PZA) against Mycobacterium tuberculosis in acidic pH and
(iii) cytotoxicity on VERO cells.

Methods:

The activity of (-)-camphene and its 15 derivatives was determined in M. tuberculosis
H37Rv in culture medium at pH 6.0 by Resazurin Microtiter Assay Plate (REMA). The activity and
combinatory study of three (-)-camphene derivatives with PZA was carried out on seven multidrugresistant
(MDR) clinical isolates by REMA and Checkerboard, respectively. The assay of 3-(4,5-
dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) bromide in VERO cells was used to determine
the derivatives’ cytotoxicity.

Results:

Four (-)-camphene derivatives, (4), (5a) (5d) and (5h), showed a reduction in the MIC
value at pH 6.0 compared to the MIC detected at pH 6.8 in M. tuberculosis H37Rv and multidrug
resistant clinical isolates. Three (-)-camphene derivatives, (4), (5d) and (5h), showed synergistic
effect (FICI ≤ 0.5) combined with PZA and were more selective for M. tuberculosis than VERO
cell (selective index from 7.7 to 84.2).

Conclusion:

Three (-)-camphene derivatives have shown to be promising anti-TB molecule scaffolds
due to their low MIC values in acidic pH against MDR M. tuberculosis clinical isolates, synergism
with PZA and low cytotoxicity.
New Patent on Electrospinning for Increasing Rutin Loading in Nanofibers
Authors: Li Na , Qian Yongfang , Zhang Zhen , Wang Ying , Lve Lihua , Wei Chunyan
Published: November 2019

Background:

The electrospinning and the bubble electrospinning provide facile ways for
the fabrication of functional nanofibers by incorporating rutin/hydroxypropyl-β-cyclodextrin inclusion
complex (RT/HP-β-CD-IC) in Polyvinyl Alcohol (PVA). Few patents on incorporation of rutin and cyclodextrin
in nanofibers has been reported.

Objective:

The study aimed at increasing the loading amount of rutin in the electrospun nanofibers to
obtain ultraviolet resistant property.

Methods:

Rutin was encapsulated in the cavity of RT/HP-β-CD and formed an inclusion complex.
Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimeter (DSC) was
used to verify the formation of inclusion complexes.

Results:

The results showed that the inclusion between rutin and HP-β-CD had been successfully
formed. The surface morphologies of nanofibrous membranes were characterized by Scanning Electron
Microscope (SEM), which indicated that adding RT/HP-β-CD inclusion complexes had little influence
on the morphologies and diameters of the fibers. Ultraviolet resistant results also confirmed the
inclusion complex had increased the loading amount in the final nanofibrous mats, and thus had good
ultraviolet resistant properties.

Conclusion:

The formed inclusion complexes had obviously enhanced the loading amount of rutin in
electrospun PVA nanofibers, indicating that encapsulation of rutin in the cavity of HP-β-CD is a good
way to increase the loading amount.
An Investigation of the Anti-Parkinsonism Potential of Co-enzyme Q10 and Co-enzyme Q10 /Levodopa-carbidopa Combination in Mice
Authors: Onaolapo Olakunle J. , Odeniyi Ademola O. , Jonathan Stephen O. , Samuel Moyinoluwa O. , Amadiegwu Deborah , Olawale Ajoke , Tiamiyu Aisha O. , Ojo Folusho O. , Yahaya Hameed A. , Ayeni Oluwadamilare J. , Onaolapo Adejoke Y.
Published: November 2019

Background:

Despite decades of research, neurodegenerative disorders like Parkinson’s
disease remain a leading cause of disability worldwide, due to the insufficient reduction of disease
burden by available medications. Recently, the benefits of dietary supplements like co-enzyme Q10
in neurodegenerative diseases have been reported.

Aim:

The protective effects of supplemental co-enzyme Q10 (CQ10) and possible additive benefits
of CQ10/Levodopa-Carbidopa (LD) in Chlorpromazine (CPZ)-induced Parkinsonism-like changes
in mice were investigated.

Methods:

Male mice were assigned to ten groups of 30 mice each. Groups included: Vehicle control
(fed Standard Diet (SD), and given intraperitoneal ip plus oral saline), LD group (fed SD, and given
ip saline plus oral LD), two groups fed CQ10-supplemented diet (at 60 and 120 mg/kg of feed), and
given ip plus oral saline, CPZ group (fed SD, and given ip CPZ plus oral saline), CPZ/LD group (fed
SD, and given ip CPZ plus oral LD), two groups fed CQ10-supplemented diet (at 60 and 120 mg/kg of
feed) and given ip CPZ plus oral saline, and another two groups fed CQ10-supplemented diet (at 60
and 120 mg/kg of feed) and given ip CPZ plus oral LD. The total duration of study was 21 days, and
treatments were administered daily. Bodyweight and food intake were measured weekly, while neurobehavioural
and biochemical tests were assessed at the end of the experimental period.

Results:

CQ10-supplementation was protective against CPZ-induced parkinsonism-like changes including,
reduction in mortality, the reversal of retardation of open-field behaviours and reduction of
catalepsy, increase in dopamine levels and decreased oxidative stress. CQ10 also showed significant
improvements in these parameters when co-administered with LD. CQ10 (in groups administered
CPZ/CQ10 60) showed greater benefit over LD on anxiety-related behaviours and also had additive
benefits on working-memory.

Conclusion:

Dietary CQ10-supplementation was associated with demonstrable benefits in CPZinduced
Parkinsonism-like changes in mice.
Entrustable Professional Activities in Oral Health for Primary Care Providers Based on a Scoping Review
Authors: Goodell Kristen H. , Ticku Shenam , Fazio Sara B. , Riedy Christine A.
Published: November 2019

Despite advances in oral health care, inequalities in oral health outcomes persist due to problems in access. With proper training, primary care providers can mitigate this inequality by providing oral health education, screening, and referral to advanced dental treatment. Diverging sets of oral health competencies and guidelines have been released or endorsed by multiple primary care disciplines. The aim of this study was to transform multiple sets of competencies into Entrustable Professional Activities (EPAs) for oral health integration into primary care training. A scoping review of the literature between January 2000 and December 2016 was conducted according to PRISMA methodology to identify all existing sets of competencies. The following primary care disciplines were included in the search: allopathic/osteopathic medical schools and residency programs in family medicine, internal medicine, and pediatrics; physician assistant programs; and nurse practitioner programs. Competencies were compared using the Health Resources and Services Administration Integration of Oral Health and Primary Care Practice competencies as the foundational set and translated into EPAs. The resulting EPAs were tested with a reactor panel. The scoping review produced 1,466 references, of which 114 were selected for full text review. Fourteen competencies were identified as being central to the integration of oral health into primary care. These were converted to seven EPAs for oral health integration into primary care and were mapped onto Accreditation Council for Graduate Medical Education residency competency domains as well to the Association of American Medical Colleges EPAs for graduating medical students. The resulting EPAs delineate the essential, observable work required of primary care providers to ensure that oral health is treated as a critical determinant of overall health.
Improving the Awareness of Musculoskeletal Disorder Risks Among Dental Educators
Authors: Partido Brian B. , Henderson Rebecca P. , Kennedy Meredith
Published: November 2019

Prolonged and static postures among dental workforce personnel may lead to work‐related musculoskeletal disorders (WMSDs). The aim of this study was to determine whether feedback involving photography and self‐assessment would improve dental educators’ postures and accuracy of ergonomic self‐assessment. This study used a randomized control design. The Modified‐Dental Operator Posture Assessment Instrument (M‐DOPAI) was used for all ergonomic evaluations over a four‐week period at one U.S. dental school. At week 1, all 30 participating dental educators were photographed and completed an M‐DOPAI without viewing the photographs. In weeks 2 and 3, the educators in the control group (N=15) completed an M‐DOPAI without any additional photographs. The educators in the training group (N=15) had additional photographs taken and used the photographs to complete an ergonomic self‐assessment with the principal investigator. From week 1 to week 4, the ergonomics training utilizing photography resulted in improvements in the dental educators’ ergonomic scores but not the accuracy of their ergonomic self‐assessments. All participants strongly agreed it was important for both dental students and dentists to understand proper ergonomics, properly apply proper ergonomics, and have accurate ergonomic self‐assessment skills in clinical practice. Although these dental educators valued ergonomic principles, they lacked training in applying these principles with dental students. Without additional training in ergonomics and self‐assessment, the development of these skills in dental students will be affected.
A Cross‐Sectional Study of Empathy Among Dental Students at King Abdulaziz University
Authors: Naguib Ghada H. , Sindi Amal M. , Attar Moaz H. , Alshouibi Ehab N. , Hamed Mohamed T.
Published: November 2019

Empathy is the fundamental substructure of moral behavior. Skillful clinicians may not necessarily be successful dentists if they do not have sufficient empathy. The aim of this study was to assess the level of empathy among dental students at King Abdulaziz University with an emphasis on the effect of gender and study level. A cross‐sectional study was carried out among third‐ to sixth‐year dental students of King Abdulaziz University in Jeddah, Saudi Arabia. A validated, self‐administered Jefferson Scale of Empathy‐Health Care Provider Student Version was distributed in academic year 2016‐17 to all 380 students in the third to sixth years. A total of 300 students responded, for a response rate of 78.9%. The results showed that the students’ mean empathy score was 84.84±11.28 on a range from 20 to 140. The fifth‐ and sixth‐year students had higher scores than the third‐ and fourth‐year students although the differences were not statistically significant. The mean empathy score of women students was significantly higher (p<0.001) than that of men students, and the women demonstrated significantly better perspective‐taking (p<0.001) than the men. This study found that the students were empathetic and had a sense of moral obligation although their mean empathy score was not as high as expected. Integrating empathic, ethical, and professional elements into the dental curriculum is needed.
Impact of HPV Immunization Training on Dental Hygiene Students’ Attitudes and Confidence Regarding HPV Preventive Education
Authors: Cotter Jane C. , Wilson Kendra J. , Mallonee Lisa F.
Published: November 2019

Human Papilloma Virus (HPV)‐related oropharyngeal cancers (OPC) have increased significantly despite availability of the HPV vaccine. HPV‐positive oropharyngeal cancer is becoming more prevalent than tobacco‐related OPC. Dental professionals screen for OPC and risk factors, but many are not prepared to address HPV immunization and prevention with patients. The aim of this study was to implement and assess a training module on HPV to increase dental providers’ knowledge, promote confidence in their ability to provide effective prevention interventions, and instill a positive attitude about recommending HPV immunization to their patients. The study used a pretest‐posttest design. Participants were dental hygiene students in one U.S. dental hygiene program in 2017. The students completed the pretest, then viewed the online training module, and completed the posttest one week later. Of the 40 students who participated in the module, 37 completed both pretest and posttest, for a response rate of 93%. From pretest to posttest, the respondents showed a significant increase (CI=0.5, p<0.001) in knowledge of HPV prevention with mean scores increasing from 8.75 to 13.32 on a 15‐point scale. The students demonstrated an increase (p<0.05) in confidence and comfort in providing HPV immunization counseling on the posttest, as well as an increase (p<0.05) in positive attitudes about recommending HPV immunization. This study found that the participants’ knowledge and confidence regarding HPV, HPV‐related OPC, and HPV immunization increased after the module, suggesting that effective education and preparation for HPV counseling can be accomplished through modular‐based education. This education would be beneficial in an institutional or professional setting.
Impact of Blended Learning on Dental Students' Performance and Satisfaction in Clinical Education
Authors: Qutieshat Abubaker S. , Abusamak Mohammad O. , Maragha Tala N.
Published: November 2019

The aim of this study was to evaluate the effectiveness of a blended learning model with a flipped classroom approach in a clinical dental education setting based on student performance and perceptions. Comparisons were made between blended learning and traditional methods for all fourth‐year dental students in two consecutive cohorts in a conservative dentistry course at a dental school in Jordan. The 2016‐17 cohort (control group) consisted of 364 students taught with conventional methods. The 2017‐18 cohort (study group) consisted of 253 students taught with blended learning using a flipped classroom method. Performance measures were two exams (online and written), two assignments, inclinic quizzes, and clinical assessment. The study also assessed the number of posts made by students in the study group on an online discussion forum. The results showed that the study group students had significantly better performance on all assessments than the control group students. The students’ overall grades in the blended learning cohort were an average 7.25 points higher than in the control cohort. Students who participated in the online forum also had better performance in the course: one participation correlated with 0.697 standard deviations higher score. Overall, students’ perceptions were positive and supported the adoption of a blended learning model in the course. These results showing improved student performance provide support for blended learning and use of an online discussion forum.
Validation of Vis-Screen Mobile Application for Easy Vision Test by General Public: A pilot study
Authors: Abdul Rahman Siti Nor Aishah , Mutalib Abdul , Baig Atif Amin , Noor Syed Hatim
Published: November 2019

Visual impairment and blindness is a serious global concern. Poor awareness and late detection are significant factors contributing to the vast number of visually impaired people worldwide. The ubiquitous use of smartphone devices enables the general public to access various services provided easily. Our Vis-Screen mobile application is developed based on the necessity for early detection of any vision problem to avoid further vision loss. Simple built-in algorithm and user-friendly features of this application suits any laypersons to do vision testing among themselves with only minimal training needed, therefore promoting the importance of healthy vision within the community.Keywords: visual acuity; mobile application; vision screening; blindnesseISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1893
Mapping Isolated Places in School in Concurrence with Bullying Possibility Elements
Authors: Abdul Wahab Azna , Md Sakip Siti Rasidah
Published: November 2019

This study aims to indicate isolated places in school in concurrence with bullying specific environments and elements. Observation student's density was conducted in the school and analysed using the Geographic Information System (GIS). A thorough observation conducted at the isolated areas using CPTED element checklist. The results of the study reveal that the CPTED element which triggers the isolated places mostly cause by maintenance condition on window and wall. Rather than that, shrubs and decorative sculpture could block the sight in isolated areas. These results may help the school's authorities to optimise existing features to decrease the possibility of bullying.Keywords: CPTED; physical environment, bullyingeISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1913
Predicting Inpatient Falls Using Natural Language Processing of Nursing Records Obtained From Japanese Electronic Medical Records: Case-Control Study (Preprint)
Authors: Nakatani Hayao , Nakao Masatoshi , Uchiyama Hidefumi , Toyoshiba Hiroyoshi , Ochiai Chikayuki
Published: November 2019

BACKGROUND

Falls in hospitals are the most common risk factor that affects the safety of inpatients and can result in severe harm. Therefore, preventing falls is one of the most important areas of risk management for health care organizations. However, existing methods for predicting falls are laborious and costly.

OBJECTIVE

The objective of this study is to verify whether hospital inpatient falls can be predicted through the analysis of a single input—unstructured nursing records obtained from Japanese electronic medical records (EMRs)—using a natural language processing (NLP) algorithm and machine learning.

METHODS

The nursing records of 335 fallers and 408 nonfallers for a 12-month period were extracted from the EMRs of an acute care hospital and randomly divided into a learning data set and test data set. The former data set was subjected to NLP and machine learning to extract morphemes that contributed to separating fallers from nonfallers to construct a model for predicting falls. Then, the latter data set was used to determine the predictive value of the model using receiver operating characteristic (ROC) analysis.

RESULTS

The prediction of falls using the test data set showed high accuracy, with an area under the ROC curve, sensitivity, specificity, and odds ratio of mean 0.834 (SD 0.005), mean 0.769 (SD 0.013), mean 0.785 (SD 0.020), and mean 12.27 (SD 1.11) for five independent experiments, respectively. The morphemes incorporated into the final model included many words closely related to known risk factors for falls, such as the use of psychotropic drugs, state of consciousness, and mobility, thereby demonstrating that an NLP algorithm combined with machine learning can effectively extract risk factors for falls from nursing records.

CONCLUSIONS

We successfully established that falls among hospital inpatients can be predicted by analyzing nursing records using an NLP algorithm and machine learning. Therefore, it may be possible to develop a fall risk monitoring system that analyzes nursing records daily and alerts health care professionals when the fall risk of an inpatient is increased.
Formation of hexamethylbenzene: chloranil charge transfer nanocrystals
Authors: Bennett Caswell R. , Khatib Aisha , Sierchio Justin M. , Van Keuren Edward
Published: November 2019

The nucleation and growth of nanoparticles can be induced using the reprecipitation method, in which a solution is rapidly mixed with a miscible non-solvent. This method has been used to create a wide variety of organic nanoparticles, including those comprised of polymers or of small molecules. Here we demonstrate the formation of charge transfer nanocrystals of the electron donor hexamethylbenzene and electron acceptor chloranil using the reprecipitation method. We achieve the rapid mixing needed for nanoparticle formation in a number of ways: using a 3D printed vortex micro-mixer, a double impinging jet mixer or direct jet injection of the solution into the non-solvent. The crystal formation kinetics are characterized over times scales from 10 ms to tens of minutes using UV-Vis absorption spectroscopy and dynamic light scattering.
Metamateriales nanoestructurados: avances en el cálculo de sus propiedades ópticas
Authors: Meza Ulises R. , Mendoza Bernardo S. , Mochán W. L.
Published: November 2019

Este artículo tiene como objetivo presentar el trabajo realizado en los últimos años en el campo de metamateriales nanoestructurados. Se muestran principalmente los trabajos realizados en el Centro de Investigaciones en Óptica A. C. en conjunto con el Instituto de Física de la UNAM.  Estos trabajos se  han centrado en el desarrollo de nuevos modelos teóricos que permitan explicar las propiedades ópticas de sistemas nanoestructurados. Además, dichos modelos se han implementado dentro de paquetes computacionales de alto rendimiento, lo cual ha posibilitado la realización de cálculos numéricos precisos, mismos que permiten conocer las cantidades físicas con las que se puede caracterizar un material; en este caso, metamateriales nanoestructurados. Mayoritariamente, dichos cálculos numéricos se han centrado en el cómputo de la función dieléctrica y la susceptibilidad no lineal, siendo de suma importancia poder predecir su valor de forma precisa por ser dos cantidades fundamentales en el entendimiento de la interacción de la luz con la materia. Además de este desarrollo teórico-numérico, se muestran algunos resultados importantes obtenidos a lo largo de este tiempo, donde se puede observar la versatilidad y flexibilidad de los cálculos así como la importancia de contar con dichas metodologías en la predicción, descripción y diseño de materiales “a la medida” de las necesidades. Por último, se presentan las perspectivas a futuro de esta investigación, así como algunos de los retos más importantes al respecto.
Las agendas estatales de innovación en México: ¿gobernanza científica discrecional o de mercado?
Authors: Anzaldo Mónica
Published: November 2019

El establecimiento de prioridades de investigación e innovación es una preocupación permanente en la gobernanza de la ciencia y la tecnología, debido a que permea la definición de los objetos de estudio, la asignación de recursos por parte del Estado y la apropiación social de los resultados. Este artículo analiza las Agendas Estatales de Innovación en México, un programa impulsado por el gobierno mexicano para definir prioridades de innovación en la escala estatal. Analíticamente, el estudio se conduce a partir de la tipología de modos de gobernanza de Hagendijk & Irwin (2006) con el objetivo de examinar en qué medida este instrumento muestra avances en la democratización de la gobernanza de la ciencia en el país. Metodológicamente, se sistematizó la información de las agendas y se realizaron entrevistas semiestructuradas a actores clave. Se concluye que las agendas coinciden con los modos de gobernanza de mercado y discrecional, pues los temas prioritarios representan los intereses de la élite empresarial y gobernante del país. Se plantea como hipótesis que en las agendas están presentes varios elementos que apuntan la orientación de la ciencia hacia una lógica de mercado alineada con el neoextractivismo, que se expande en la región latinoamericana.
SOSIALISASI DAN PELATIHAN SAFETY HOUSE DI KECAMATAN CIBOGO KABUPATEN SUBANG PROVINSI JAWA BARAT
Authors: Ekawandani Nunik , Faujiyah Firdhani , Rum Avid Inang
Published: November 2019

ABSTAKKesehatan dan keselamatan adalah aspek penting dalam kehidupan manusia, baik dalam bekerja ataupun dalam kehidupan sehari-hari. Hal tersebut memberikan dampak negatif bila tidak diperhatikan karena kesehatan dan kseselamatan memberikan rasa aman dan nyaman pada kita pada setiap kegiatan. Setiap pekerjaan atau tindakan selalu mempunyai risiko sekecil apapun, apalagi bila pekerjaan yang memang benar-benar mempunyai risiko yang tinggi seperti bekerja di bidang manufaktur atau di bidang migas. Kesehatan dan keselamatan di rumah tinggal pun tak kalah pentingnya, seorang ibu rumah tangga ataupun pembantu rumah tangga mempunyai risiko kegiatan yang tinggi seperti kegiatan di dapur adanya tabung gas, api  dari kompor yang menyala, minyak panas, alat rumah tangga bertenaga listrik, bahan kimia yang digunakan saat membersihkan kamar mandi, mencuci, obat anti serangga dan lainnya. Karena prinsipnya dalam K3 yang harus diamankan terlebih dahulu adalah lingkungannya (safe condition) barulah dilakukan pengamanan dalam tindakan (safe act). Kegiatan ini disajikan dalam bentuk workshop, praktik, diskusi, tanya jawab dan tugas mandiri. Hasil evaluasi kegiatan pada awal masih peserta masih sangat awam dengan istilah K3 atau safety house, namun setelah selesai kegiatan ini peserta dapat memahami dan menunjukan sikap safety di rumah dan lingkungan sekitar. Seperti halnya mereka dapat  mengidentifikasi berbagai macam bahaya dan mulai menata ulang kembali rumah tinggal mereka.ABSTRACTHealth and safety are important aspects of human life, both at work and in everyday life. This has a negative impact if it is not considered because health and safety provide us with a sense of security and comfort in every activity. Every job or action always has the slightest risk, especially if the work really does have a high risk such as working in manufacturing or in the oil and gas sector. Health and safety at home is equally important, a housewife or housemaid has a high risk of activities such as activities in the kitchen with gas cylinders, fire from burning stoves, hot oil, electric-powered household appliances, chemicals that used when cleaning bathrooms, washing, insect repellent and others. Because the principle in K3 that must be secured first is the environment (safe condition), then safeguards are carried out. This activity is presented in the form of workshops, practices, discussions, question and answer and independent assignments. The results of the activity evaluation at the beginning were that participants were still very unfamiliar with the term K3 or safety house, but after completing this activity the participants could understand and show safety attitudes at home and the surrounding environment. Just as they can identify various kinds of hazards and start rearranging their homes.