bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of the medicine «Vizk'yu» in treatment of exudative form of age-related macular degeneration on the example of a clinical case
Authors:   Surgut State University, Vasilyev A.R. , Santoro E.Y. ,   Surgut State University, Gramatikopolo E.O. ,   Surgut State University
Published: June 2022

Purpose. To evaluate the effectiveness of treating a patient with exudative form of age-related macular degeneration (AMD) by intravitreal injection of the medicine “Vizk'yu”. Material and methods. The results of the injection of medicine “Vizk'yu” were analyzed. To assess the effectiveness of the medicine, the patient underwent visometry and optical coherence tomography (OCT) using the Optopol SOCT Copernicus device. Results. Patient R., male, 61 years old, diagnosed with exudative AMD in the right eye received a treatment in the form of an intravitreal injection of “Lucentis” into the right eye from December 12, 2020, the initial tomography data are shown in fig. 1. Patient received three loading injections, then the treatment was continued in a proactive mode. From December 2020 to January 2022 he received 7 injections of “Lucentis”. In the course of treatment, an insufficient effect in the suppression of neovascularization was revealed (November 23, 2021), which was expressed in the presence of subretinal fluid and intraretinal fluid, which is shown in the results of OCT in fig. 2. In connection with this, it was decided to transfer the patient from “Lucentis” therapy to “Vizk'yu” therapy. “Vizk'yu” therapy was started on January 11, 2022 with monthly boot injections. So far, 3 injections have been made. After changing the therapy, there is a positive trend (fig. 4–5), which is expressed in a significant decrease in the amount of intraretinal and subretinal fluids, as well as in the stabilization of visual acuity (fig. 3). Conclusion. The use of “Vizk'yu” on a patient with exudative form of AMD led to an improvement in the morphological state of the retina, to resorption of subretinal and intraretinal fluids, contributed to a persistent decrease in the retinal thickness in fovea, and also stabilized visual acuity. Keywords: “Vizk'yu”, “Lucentis”, age-related macular degeneration, macular edema, OCT.
Clinical cases of cataract phacoemulsification in patients with extreme degrees of ametropia
Authors:   S.N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health, Moscow, Grigoryeva Y.V. , Tsikarishvili N.R ,   S.N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health, Moscow, Khliyan K.G. ,   S.N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health, Moscow
Published: June 2022

Purpose. To evaluate the features of the phacoemulsification technique with IOL implantation and clinical and functional results in patients with extreme eyeball length. Material and methods. There were 2 patients under observation: a 70-year-old patient with a diagnosis of OU: Complicated cataract. High myopia. Amblyopia moderate. Primary open-angle glaucoma 2A. Visual acuity at admission vis OD = 0.001 n.c.; vis OS = 0.04 sph +2.00 D cyl –2.50 D ax 105° = 0.1. The second patient, aged 65, was diagnosed with OU: Complicated cataract. Hyperopia of a high degree. Amblyopia moderate. Primary open-angle glaucoma 1A, operated. Visual acuity at admission OD = 0.01 sph +11.00 D cyl +1.50 D ax 110° = 0.2; OS = 0.01 sph +11.00 D cyl +1.00 D ax 105 = 0.1. Both patients underwent phacoemulsification with Asphina IOL implantation (Carl Zeiss Meditec AG, Germany): the right eye of patient N 1 and the left eye of patient N 2. Results. A month after the operation, the uncorrected visual acuity in the first patient was Vis OD = 0.15. In the second patient, a month after the operation, visual acuity was Vis OS = 0.04 sph (+) 11.0 D = 0.2. Both patients are subjectively satisfied with the obtained visual functions. Conclusion. Thus, this clinical case demonstrates a very successful implementation of cataract phacoemulsification with IOL implantation in patients with extreme eyeball length. Keywords: microphthalmos, high myopia, high degree ametropia, complicated cataract, cataract phacoemulsification.
Acquired facial angioedema and the periorbital region. Clinical case
Authors:   Kirov state ophthalmology hospital, Krupinina V.S. , Demakova L.V. ,   Kirov state ophthalmology hospital,   FSBEI HE Kirov SMU MOH Russia, Plotnikova Y.A. ,   Kirov state ophthalmology hospital,   FSBEI HE Kirov SMU MOH Russia, Kudyavtseva Y.V. ,   Kirov state ophthalmology hospital,   FSBEI HE Kirov SMU MOH Russia
Published: June 2022

The purpose of the work was to analyze the features of differential diagnosis of acquired angioedema of the face and periorbital region on the example of a clinical case. Material and methods. A 62-year-old patient with complaints of edema of the upper and lower eyelids, zygomatic region and cheeks, decreased vision of the left eye applied for a consultative appointment at the polyclinic. The patient underwent a comprehensive examination, on the basis of which Waldenstrom's macroglobulinemia was diagnosed. Results. In the presented patient, ocular manifestations of the disease revealed such manifestations of the disease as macroglobulinemic retinopathy, persistent angioedema of the paraorbital region and soft tissues of the face. Conclusion. Non-inflammatory edema of the eyelids is a manifestation of both ophthalmological and systemic pathology, which creates the need for a thorough differential diagnosis and requires an interdisciplinary approach to identify the cause of the disease. Keywords: Waldenstrom's macroglobulinemia, angioedema.
Implantation of myoring for correction of high myopia in a patient with nystagmus
Authors:   S.Fyodorov Eye Microsurgery Federal State Institution, Ministry of Health of the Russian Federation, Cheboksary, Russian Federation, Kulikova I.L. ,   SAI of APE of the Chuvash Republic “Institute for Advanced Training of Doctors” of Ministry of Health of the Chuvash Republic, Cheboksary, Russian Federation, Terentyeva A.E. ,   S.Fyodorov Eye Microsurgery Federal State Institution, Ministry of Health of the Russian Federation, Cheboksary, Russian Federation, Sinitsyn M.V. ,   S.Fyodorov Eye Microsurgery Federal State Institution, Ministry of Health of the Russian Federation, Cheboksary, Russian Federation,   SAI of APE of the Chuvash Republic “Institute for Advanced Training of Doctors” of Ministry of Health of the Chuvash Republic, Cheboksary, Russian Federation
Published: June 2022

Purpose. Analysis of clinical and functional results and quality of life after implantation of MyoRing in a patient with high myopia and nystagmus. Material and methods. Patient M., 29 years old, was implanted a myoRing using a femtosecond laser to correct high myopia. Uncorrected visual acuity (UCVA) on the operated eye before surgery was 0.03, corrected visual acuity (CVA) 0.5, spherical refractive component –10.25 D, cylindrical component –4.00 D. Keratometry OD 41.5 × 45.25 × 174°. Corneal hysteresis (CH) was 7.3 mm Hg and corneal resistance factor (CRF) was 6.6 mm Hg. The thickness of cornea in center was 513µm. The data on higher-order aberrations were in line with the generally accepted norm. Observation period – 2 years. Results. 2 years after the operation, visual acuity without correction at OD 0.6, with correction – 0.7. The spherical component was 0.75 D, cylindrical component was –1.25 D. Keratometry OD 30.5 × 31.5 × 171°. Corneal hysteresis was 8.5 mm Hg, corneal resistance factor was 6.9 mm Hg. The thickness of cornea in center was 518µm. All higher-order aberrations decreased, except for vertical Coma (Z3/–1), which increased by 0.35µm, horizontal Coma (Z3/+1), which increased by –0.06µm. According to the results of the questionnaire, the patient noted a significant improvement in visual functions in the period from 3 to 12 months. Problems with the quality of vision in conditions of reduced contrast and complaints of halos were present only in the first months (3–4 months) after surgery. Conclusion. The MyoRing implantation method for correction of high myopia in a patient with nystagmus is highly effective, safe, providing a refractive effect on the spherical and cylindrical component of refraction and enhancing the biomechanical properties of cornea. Keywords: myopia and complex myopic astigmatism, thin cornea, MyoRing ring, femtosecond laser.
Traumatic retinopathy of purcher. Clinical case
Authors:   S.N. Fedorov NMRC «MNTK «Eye Microsurgery», Volgograd Branch, Purshak S.M. , Melikhova I.A. ,   S.N. Fedorov NMRC «MNTK «Eye Microsurgery», Volgograd Branch
Published: June 2022

Purpose. To present a rare clinical case of Purcher's retinopathy after a closed head injury. Material and methods. Patient R., 56 years old, after a traumatic brain injury with complaints of a sharp decrease in vision in both eyes. Performed optical coherence tomography with the function of angiography to identify specific markers of the disease, diagnosed with Purcher's retinopathy. Results. The patient was prescribed treatment with glucocorticosteroids, non-steroidal anti-inflammatory drugs and diuretics. Angio- and neuroprotective therapy was also carried out. A week later, the patient noted a positive trend from the treatment. Vision increased to VOD = 0.5 does not correct, VOS = 0.5 does not correct. On the fundus, complete resorption of hemorrhages and Purcher's spots. On the images of optical coherence tomography with the function of angiography, there are no areas of ischemia, the edema was stopped. Conclusion. The presented clinical case of Purcher's retinopathy proves the possibility of developing acute vascular pathology in the fundus, against the background of a closed craniocerebral injury, without direct impact on the eyeball. Optical coherence tomography with angiography function helps in making the correct diagnosis with the identification of all specific markers of the disease, such as ischemic edema, Purcher's spots and retinal hemorrhages. Keywords: retinopathy of Purcher, Purcher's spots, retinal hemorrhages, optical coherence tomography with the function of angiography.
Efficacy and safety of myopia correction by transfrk method in combination with the use of therapeutic ml impregnated with dexamethasone 0.1 % Solution
Authors:   Ophthalmological Clinic “Sphere”, Moscow, Russian Federation, Movsesian M.H. , Parshina V.A. ,   Ophthalmological Clinic “Sphere”, Moscow, Russian Federation, Eskina E.N. ,   Ophthalmological Clinic “Sphere”, Moscow, Russian Federation,   Academy of Postgraduate Education of the Federal State Budgetary Institution “Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies” of the Federal Medical and Biological Agency, Moscow, Russian Federation
Published: June 2022

Purpose. To evaluate the efficacy and safety of myopia correction by the TransPRK method using therapeutic soft contact lens (SCL) impregnated with a 0.1 % dexamethasone solution Material and methods. A prospective, controlled study included 32 patients (64 eyes). The left eyes were combined into the “With DEX” study group, the right ones into the “Without DEX” control group. After the TransPRK was performed, SCL soaked with dexamethasone was put on the eyes of the “With DEX” group. The same SCL without impregnation was put on the eyes of second group “Without DEX”. Results. 1 and 3 months after, the operation there were no significant differences in UDVA between the groups. Mean UDVA 3 months after the operation in the group “With DEX” was 1.0 ± 0, in the group “Without DEX” 1.0 ± 0.1 (p-value = 0.625). There were no significant differences in the rate of formation of the refractive result, its predictability and stability. After 1 month in the “Without DEX” group, the difference in the level of UDVA before surgery and CDVA after was the same (without loss of the number of lines read) in 44 %, in the “With DEX” group, in 67 % (p-value = 0.607). The same picture was observed after 3 months, in the group "With DEX" – in 83 %, “Without DEX” – in 61 % (p-value = 0.607). The difference is not statistically significant, but there was a trend towards an accelerated recovery of UDVA in the “With DEX” group. The pain syndrome was significantly less in the “With DEX” group (p-value = 0.021). There were no significant differences in the epithelialization time between groups, as well as subepithelial fibroplasia. Conclusion. According to the results obtained, TransPRK with therapeutic SCL impregnated with dexamethasone can be considered as an effective and safe method, which also makes possible to reduce pain in the early postoperative period without delaying epithelialization. Keywords: dexamethasone, corneal syndrome, photorefractive keratotomy, therapeutic lens.
Сonceptual approach to diagnostics and treatment of ophthalmic rosacea
Authors:   Center for the development of professional qualifications medical workers, Uzbekistan, Tashkent, Abdullaev S.R. , Babakhanova D.M ,   Center for the development of professional qualifications medical workers, Uzbekistan, Tashkent, Maksudova L.M ,   Center for the development of professional qualifications medical workers, Uzbekistan, Tashkent, Khudoiberganov A.R. ,   Center for the development of professional qualifications medical workers, Uzbekistan, Tashkent
Published: June 2022

The aim of the work is to study the variety of clinical manifesta-tions, the effectiveness of the treatment of ophthalmic rosacea with the use of anti-bacterial, antiparasitic, desensitizing drugs of general and local action, lubricants. An important aspect is the elimination of chronic foci of infection, the treatment of concomitant diseases, the restoration of the immune and endocrine status. Keywords: ophthalmic rosacea, clinical types, diagnostics and treatment.
Macular retinal blood flow in patients with normal tension glaucoma
Authors:   Bashkir State Medical University, Ufa, Arslanova A.I. ,   Hospital 8, Ufa, Nugmanova A.R. ,   Bashkir State Medical University, Ufa
Published: June 2022

Purpose. To study the blood flow of the macular area of the retina in the superficial and deep choroid plexuses using the OCTA method in patients with newly diagnosed normal tension glaucoma. Material and methods. 29 patients (50 eyes) with newly diagnosed normal pressure glaucoma aged 45 to 65 years with initial (28.0 %), advanced (42 %) and advanced (30 %) stages of the disease were examined. Results and discussion. The OCTA method revealed changes in the indicators of microcirculation of the macular zone of the retina in the fovea and parafovea. The index of vessel density in patients with different stages of the disease was significantly reduced in the superficial and deep vascular plexuses and by sector in the eyes with different stages of the disease. Conclusion. In patients with normal tension glaucoma, according to OCTA data, microcirculation disorders of the macular area of the retina at the levels of the superficial and deep vascular plexuses were revealed, increasing with the progression of the disease. Keywords: normal pressure glaucoma, primary open angle glaucoma, optical coherence tomography with angiography, microcirculation.
Comparative analysis of electrophysiological and perimetric parameters in patients with suspected glaucoma
Authors:   Republican Specialized Scientific and Practical Medical Center of Eye Microsurgery, Uzbekistan, Zakirkhodjayeva M.A. , Karimova M.K. ,   Republican Specialized Scientific and Practical Medical Center of Eye Microsurgery, Uzbekistan, Soliyev T.Y. ,   Republican Specialized Scientific and Practical Medical Center of Eye Microsurgery, Uzbekistan
Published: June 2022

Purpose. To compare electrophysiological and perimetric parameters in patients with suspected glaucoma. Materials and methods. 42 patients (84 eyes) with a diagnosis of suspected glaucoma were examined in the RSNPCMG. Visual acuity of patients with ametropia correction was 0.9–1.0. Refractive errors did not exceed 3.0 diopters, concomitant visual analyzer disorders were not detected. None of the examined patients received local drug hypotensive therapy at the time of diagnosis. The average age of the patients was 50.5 ± 2.5 years. The comparison group consisted of 20 people without changes in visual functions of the corresponding gender and age. Electrophysiological and perimetric methods were used: blue-yellow threshold static perimetry, color-component blue-yellow electroretinography of the study of the visual organ to assess the functional state of the visual system with standard methods of examination of the visual organ. Results. The results of standard and color-component methods of perimetry research, as well as electrophysiological indicators were processed using the applied package of research methods Statistica 6.0. When analyzing the main functional perimetric indices and the nature of the topography and depth of defects of the central field of vision (MD, PSD, CPSD), a significant change in the thresholds of light sensitivity of the blue-yellow perimetry relative to the standard method of investigation was noted. When conducting electrophysiological studies, the criteria that have the greatest similarity in damage to the S-cone system of the retina were selected: PERG, oscillatory potentials, synecolumbular electroretinography (S-CON ERG). Conclusion. 1. The developed complex of functional research methods makes it possible to identify the presence of changes in the visual system at the early preclinical stages of the development of glaucoma optic neuropathy. 2. The proposed method of separation of light and color component channels of the visual analyzer increases the sensitivity and specificity of the lesion of the retina of the optic nerve in the development of glaucoma changes. 3. Indicators of oscillatory potentials of ERG are a predictor of ischemic retinal changes in glaucoma. 4. The results of the studies indicate the presence of specific S-cone channels and the effectiveness of detecting damage to retinal ganglion cells using the coniocellular retinal response system. Key words: oscillator potentials, glaucomatous optic neuropathy, blue cone ERG, retinal ganglion cells.
Comparison of early results and safety of different methods of retinal inner limiting membrane peeling in the surgical treatment of diabetic retinopathy
Authors:   FGBNU “Scientific Research Institute of Eye Diseases” of the Ministry of Education and Science of Russia, Moscow, Russia, Filippov V.M. , Petrachkov D.V. ,   FGBNU “Scientific Research Institute of Eye Diseases” of the Ministry of Education and Science of Russia, Moscow, Russia
Published: June 2022

Relevance. Surgical treatment (VRS) of diabetic retinopathy (DR) is the method of choice in the development of its complications and in combination of DR with other vitreoretinal diseases. The procedure of the retinal inner limiting membrane (ILM) peeling is a debatable stage of the VRS, there is no single concept for its application, and the analysis of its results provides conflicting data. The purpose of the study was a comparative analysis of various methods of retinal ILM peeling in terms of safety, functional and anatomical results in the early postoperative period (up to 3 months). Material and methods. A randomized study was conducted on three comparable groups of patients with proliferative DR (PDR). All patients underwent comparable VRS treatment, the groups differed only in the stage of ILM peeling: in group 1, ILM peeling was not performed, in group 2, it was performed within the inter-arcade space, in group 3, dosed center-sparing ILM peeling was performed. Results. ILM peeling methods were comparable in terms of safety. However, in group 2, a lamellar macular hole (LMH) formation was noted in two cases. Also intraoperatively among patients of group 2, five cases of transient retinal neuroepithelial detachment (tNED) associated with ILM peeling were detected. Functional and anatomical results in the groups were comparable and did not differ significantly. A possible predictive role of the central macular volume in the prognosis of postoperative diabetic macular edema (DME) was revealed. A relationship between tNED and the risks of developing DME and LMH after surgery has been established. Conclusion. In the early postoperative period, the results of treatment using different methods of ILM peeling are comparable. Their further study and analysis of long-term results are required. Keywords: diabetic retinopathy, diabetic macular edema, vitreoretinal surgery, ILM peeling, dosed center-sparing ILM peeling, optical coherence tomography, lamellar macular hole.
Kinerja Tenaga Pendamping Desa Dalam Pembangunan Desa Di Kabupaten Bungo Provinsi Jambi (Studi Di Desa Koto Jayo Dan Desa Tanah Tumbuh Kecamatan Tanah Tumbuh)
Authors: Adriansah Muhammad , Sartika Ika , Ony Andi
Published: June 2022

This thesis is entitled Implementation of Labour Policy in Bekasi Regency which raises the issue of how the implementation of labour policy in Bekasi Regency is seen from its dimensions and determinants and how to improve labour services in order to increase job opportunities in the Bekasi Regency area. The theory used as an analytical knife in writing this thesis is the theory of policy implementation model according to Muchlis Hamdi (2014) which explains the description of the movement dynamics of policy implementation, namely the dimensions of productivity, linearity and efficiency and the factors that can affect the success of policy implementation, namely the determinants of policysubstance, behavior of implementing tasks, network interactions, target group participation and resources. The method used is a qualitative approach, data collection techniques are interviews, document review, observation, and triangulation. Based on the data and analysis of the implementation of labour policies in Bekasi Regency, seen from the dimensions and determinants, some results are obtained that the implementation of labour policies in Bekasi Regency has been going quite well which can be seen from the achievement of performance targets and SPM increased from 2018 and can meet the target in 2019, the use of funds, infrastructure and implementing officers in supporting employment services is quiteefficient, the contents of employment policies, especially employment services with other policies are aligned , the level of performance and ability to make the initiative of implementing officers is quite good, the interaction of the network of implementing officers is quite harmonious, the participation of the target group both job seekers and company on the implementation of labour policies in Bekasi Regency is quite high, resource support is good, adequate funds,availability of implementers and the availability of equipment for the implementation of labor policies in Bekasi Regency is quite good. However, in order to improve employment services in the context of increasing job opportunities, apartfrom optimizing things that are already going well, it is necessary to make efforts, including the preparation ofstandard operating procedures (SOPs) in overall employment services, drafting Regent regulations to regulate technical implementation guidelines. Bekasi Regency regional regulation number 4 of 2016 concerning Employment, increasing competence for functional officers who are equal to work delivery results, increasing network interaction with employees of the labour inspector Office of West Java Province, increasing the competence and skills of local job seekers in Bekasi Regency and the use of information technology and communication in employment services.
Kırsal Kalkınmada Etkili Sosyo-Ekonomik Değişkenlerin Analizi ve Mekânsal Farklılaşması
Authors: ÖZDEN Fatih
Published: June 2022

Araştırmanın temel amacı araştırma kapsamındaki köylerin hanehalkı düzeyindeki sosyo-ekonomik değişkenlerinin mekânsal olarak nasıl farklılaştığını ortaya koymak ve hanehalkı gelir grupları üzerine etki eden değişkenleri belirlemektir. Bu temel amaç çerçevesinde Küçük Menderes Havzasında İzmir ili sınırlarında bulunan beş ilçenin her birinden ikisi ovada, ikisi de dağ-yamaç bölgede konumlanmış dört köy belirlenmiştir. Böylece toplam 20 köyde, oransal örnek hacmi yöntemine göre % 95 güven aralığı ve % 7,5 hata payı ile belirlenen 171 hanehalkı temsilcisiyle görüşülmüştür. Verilerin analizinde tanımlayıcı istatistiklerden yararlanılmış, parametrik ve parametrik olmayan testler kullanılmıştır. Ayrıca hanehalkı gelir grupları arasında geçişkenliğe etki eden faktörler lojistik regresyon analiziyle tespit edilmiştir. Analiz sonuçları dağ-yamaç köylerinin ova köylerine göre sosyo-ekonomik parametreler açısından dezavantajlı durumda olduğunu göstermektedir. Eğitim, hanedeki birey sayısı, toplam işlenen alan, büyükbaş hayvan sayısı ve tarım dışı gelir gibi değişkenlerin gelir grupları üzerinde istatistiksel olarak anlamlı bir etkiye sahip oldukları bulunmuştur. Kırsal kalkınmanın sağlanabilmesi adına sosyo-ekonomik ve kültürel yatırımların artırılması gerekmektedir. Ayrıca kırsal kalkınmanın, kaynakların daha etkin kullanımını sağlayacak şekilde, kırsal alanların fiziksel ve beşeri kalkınmasını içeren çok boyutlu özellikleri ile bölgeler arası ve bölge içi gelişmişlik farklarının dikkate alınarak planlaması önem taşımaktadır.
Query Rewriting for DL-Lite with n-ary Concrete Domains (Extended Version)
Authors: Baader Franz , Borgwardt Stefan , Lippmann Marcel
Published: June 2022

We investigate ontology-based query answering (OBQA) in a setting where both the ontology and the query can refer to concrete values such as numbers and strings. In contrast to previous work on this topic, the built-in predicates used to compare values are not restricted to being unary. We introduce restrictions on these predicates and on the ontology language that allow us to reduce OBQA to query answering in databases using the so-called combined rewriting approach. Though at first sight our restrictions are different from the ones used in previous work, we show that our results strictly subsume some of the existing first-order rewritability results for unary predicates.
Using Ontologies to Query Probabilistic Numerical Data (Extended Version)
Authors: Baader Franz , Koopmann Patrick , Turhan Anni-Yasmin
Published: June 2022

We consider ontology-based query answering in a setting where some of the data are numerical and of a probabilistic nature, such as data obtained from uncertain sensor readings. The uncertainty for such numerical values can be more precisely represented by continuous probability distributions than by discrete probabilities for numerical facts concerning exact values. For this reason, we extend existing approaches using discrete probability distributions over facts by continuous probability distributions over numerical values. We determine the exact (data and combined) complexity of query answering in extensions of the well-known description logics EL and ALC with numerical comparison operators in this probabilistic setting.
Terminological knowledge aquisition in probalistic description logic
Authors: Kriegel Francesco
Published: June 2022

For a probabilistic extension of the description logic EL⊥, we consider the task of automatic acquisition of terminological knowledge from a given probabilistic interpretation. Basically, such a probabilistic interpretation is a family of directed graphs the vertices and edges of which are labeled, and where a discrete probabilitymeasure on this graph family is present. The goal is to derive so-called concept inclusions which are expressible in the considered probabilistic description logic and which hold true in the given probabilistic interpretation. A procedure for an appropriate axiomatization of such graph families is proposed and its soundness and completeness is justified.
Carrier Gas Triggered Controlled Biolistic Delivery of DNA and Protein Therapeutics from Metal-Organic Frameworks
Authors: Wijesundara Yalini H. , Herbert Fabian C , Trashi Orikeda , Trashi Ikeda , Brohlin Olivia R. , Kumari Sneha , Howlett Thomas , Benjamin Candace E. , Shahrivarkevishahi Arezoo , Diwakara Shashini D. , Perera Sachini D. , Cornelius Samuel A. , Vizuet Juan P , Balkus Kenneth J. , Smaldone Ronald A. , De Nisco Nicole J , Gassensmith Jeremiah
Published: June 2022

Abstract: The efficacy and specificity of protein, DNA, and RNA-based drugs have made them popular in the clinic; however, their susceptibility to environmental stressors adds significant challenges to formulating biomacromolecules into delivery systems where the kinetics of release can be tuned. Further, these drugs are often delivered via injection, which requires skilled medical personnel and produces biohazardous waste. Here, we report an approach that allows for the controlled delivery of DNA and protein therapeutics to allow for either burst or slow-release kinetics without altering the formulation; further, we show we can deliver these materials into the tissues of very different organisms without the use of needles. We show that biomaterials encapsulated within the highly porous metal-organic Framework ZIF-8 are stable as a powder formulation that can be shot into tissue with a low-cost gas-powered “MOF-Jet” for direct delivery into living tissues of plants and animals and the release of the biomaterials can be controlled by judiciously choosing the compressed gas used in the gun. Many MOFs, including ZIF-8, are acid labile and readily dissolve at low pH. When CO2 is used as the carrier gas to shoot MOFs into moist tissue, we show that we can create a transient and weakly acidic local environment that causes the near-instantaneous release of the biomolecules. Conversely, when air is used, the MOF is delivered into tissue and degrades slowly over a week, releasing biomolecules. This innovation represents the first example of biolistic-mediated controlled delivery of biomolecules with ZIF-8 and provides a powerful tool for fundamental and applied plant and animal sciences research.
Impact of the current density on paramagnetic NMR properties
Authors: Franzke Yannick J. , Holzer Christof
Published: June 2022

Meta-generalized gradient approximations (meta-GGAs) and local hybrid functionals generally depend on the kinetic energy density τ. For magnetic properties, this necessitates generalizations to ensure gauge invariance. In most implementations, τ is generalized by incorporating the external magnetic field. However, this introduces artifacts in the response of the density matrix and does not satisfy the iso-orbital constraint. Here, we extend previous approaches based on the current density to paramagnetic NMR shieldings and EPR g-tensors. The impact is assessed for main-group compounds and transition-metal complexes considering 25 density functional approximations. It is shown that the current density leads to substantial improvements—especially for the popular Minnesota and SCAN functional families. Thus, we strongly recommend to use the current density generalized τ in paramagnetic NMR and EPR calculations with meta-GGAs.
Mixed-Reference Spin-Flip Time-Dependent Density Functional Theory for Accurate X-ray Absorption Spectroscopy
Authors: Park Woojin , Alías-Rodríguez Marc , Cho Daeheum , Lee Seunghoon , Huix-Rotllant Miquel , Choi Cheol Ho
Published: June 2022

It is demonstrated that the challenging core hole-particle (CHP) orbital relaxation for core electron spectra can be readily achieved by the mixed-reference spin-flip (MRSF)-TDDFT. With the additional scalar relativistic effects on K-edge excitation energies of 24 second- and 17 third-row molecules, the particular ∆CHP-MRSF(R) exhibited near perfect predictions with RMSE ∼ 0.5 eV, featuring a median value of 0.3 and and an interquartile range of 0.4. Overall, the CHP effect is 2 ∼ 4 times stronger than relativistic ones, contributing more than 20 eV in the cases of sulfur and chlorine third-row atoms. Such high precision allows to explain the splitting and spectral shapes of O, N and C atom K-edges in the ground state of thymine with atom as well as orbital specific accuracy. The same protocol with a double hole particle relaxation also produced remarkably accurate K-edge spectra of core to valence hole excitation energies from the first (nO8π∗) and second (ππ∗) excited states of thymine, confirming the assignment of 1s → n excitation for the experimentally observed 526.4 eV peak. Regarding both accuracy and practicality, therefore, MRSF-TDDFT provides a promising protocol for core electron spectra both of ground and excited electronic states alike.
Simultaneous neutron and X-ray tomography for ex-situ 3D visualization of graphite anode degradation in extremely fast-charged lithium-ion batteries.
Authors: Yusuf Maha , LaManna Jacob M. , Paul Partha P. , Agyeman-Budu David N. , Cao Chuntian , Dunlop Alison R. , Jansen Andrew N. , Polzin Bryant J. , Trask Stephen E. , Tanim Tanvir R. , Dufek Eric J. , Thampy Vivek , Steinrück Hans-Georg , Toney Michael F. , Weker Johanna Nelson
Published: June 2022

Extreme fast charging (XFC) of commercial lithium-ion batteries (LIBs) in ≤10-15 minutes will significantly advance the deployment of electric vehicles globally. However, XFC leads to considerable capacity fade, mainly due to graphite anode degradation. Non-destructive three-dimensional (3D) investigation of XFC-cycled anodes is crucial to connect degradation with capacity loss. Here, we demonstrate the viability of simultaneous neutron and X-ray tomography (NeXT) for ex-situ 3D visualization of graphite anode degradation. NeXT is advantageous because of the sensitivity of neutrons to Li and H and X-rays to Cu. We combine the neutron and X-ray tomography with micron resolution for material identification and segmentation on one pristine and one XFC-cycled graphite anode, thereby underscoring the benefits of the simultaneous nature of NeXT. Our ex-situ results pave the way for the design of NeXT-friendly LIB geometries that will allow operando and/or in-situ 3D visualization of graphite anode degradation during XFC.
Surface Characterization of PEKK Modified by stron-tium–hydroxyapatite coating as implant material Via the magnetron sputtering Deposition technique
Authors: Jani Ghasak H , Fatalla Abdalbseet A
Published: June 2022

Background: The best material for dental implants is polyetherketoneketone (PEKK). However, this substance is neither osteoinductive nor osteoconductive, preventing direct bone apposition. Modifying the PEKK with bioactive elements like strontium hydroxyapatite is one method to overcome this (Sr-HA). Due to the technique's capacity to provide better control over the coating's properties, RF magnetron sputtering has been found to be a particularly useful technique for deposition.

Materials and methods : With specific sputtering conditions, the RF magnetron technique was employed to provide a homogeneous and thin coating on Polyetherketoneketone substrates.. the coatings were characterized by Contact angle, adhesion test, X-ray diffraction (XRD), atomic force microscope and Elemental Analysis with Energy Dispersive X-Ray (EDX)

Results : indicated that strontium hydroxyapatite had successfully deposited onto the surface with significant improvement in the wettability value to provide a suitable environment for cell attachment, spreading, proliferation, and differentiation

Conclusion: Coating PEKK with RF magnetron sputtering can provide homogeneous surfaces laying the groundwork for improving PEKK's potential bioactivity, such as surface wettability. Wetting qualities are critical in implantable materials and are used to predict future osseointegration success.
Effects of various analgesics on pain perception and rate of tooth movement: a randomized controlled clinical study
Authors: Abdaljawwad Asem A , Al-Groosh Dheaa H
Published: June 2022

Background: Pain is one of the most reported side effects of orthodontic treatment despite the advanced technology in orthodontics. Many analgesics have been introduced to control orthodontic pain including acetaminophen and selective and nonselective nonsteroidal anti-inflammatory drugs. The great concern about these drugs is their adverse effect on rate of teeth movement. Aims: The purpose of this study was to evaluate and compare the effect of acetaminophen, ibuprofen and etoricoxib on pain perception and their influence on the rate of teeth movement during leveling and alignment stage. Methods: Forty patients were evenly and randomly distributed in a blinded way to one of four groups: placebo (starch capsules), acetaminophen 500mg thrice daily, ibuprofen 400mg thrice daily, and etoricoxib 60mg once daily. The drugs were given one hour before bonding and archwire placement and continued for three days. A visual analogue scale was used to express pain levels before and after archwire placement, on the first, second, third, and seventh day. Little’s irregularity index was measured before bonding and at every activation visit until the end of the alignment and leveling stage. Results: All three drugs showed a lower pain level than placebo at the bonding and first activation visits. Etoricoxib showed the least pain level among other drugs followed by ibuprofen. No statistically significant differences were found between the drug groups and the placebo at the second and third activation visits. No statistically significant differences were detected between the 4 experimental groups concerning the rate of teeth movement. Conclusions: The three drugs were only effective in controlling pain during the first two visits of orthodontic treatment; and etoricoxib 60mg/day was the best. All three drugs had no influence on rate of teeth movement when used in their least recommended dose.
Assessment of salivary immunoglobulin A, interleu-kin-6 and C-reactive protein in chronic kidney dis-ease patients on hemodialysis and on conservative treatment
Authors: Salim Ithar K , Diajil Ameena R
Published: June 2022

Background: Chronic kidney disease is a gradual loss of kidney function with diabetes and hypertension as the leading cause. Chronic kidney disease is one of these systemic diseases that can affect salivary contents. Aims: This study aimed to assess salivary immunoglobulin A, interleukin-6 and C- reactive protein in chronic kidney disease patients on hemodialysis and those on conservative treatment in comparison with control subjects. Materials and methods: Ninety subjects were included in this study divided into three groups: 30 patients with chronic kidney disease on hemodialysis for at least 6 months ago; 30 patients with chronic kidney disease on conservative treatment and 30 healthy control subjects. Secretory immunoglobulin A, interleukin-6 and C- reactive protein in saliva samples were measured by enzyme-linked immunosorbent assay ELISA. Results: No significant difference in salivary immunoglobulin A level among study groups was seen. A significant increase in salivary interleukin-6 and C- reactive protein in both chronic kidney disease patients on hemodialysis and those on conservative treatment compared to the control group. While, no significant salivary IL-6 and CRP differences were seen between both patient groups, on hemodialysis and conservative treatment. Conclusions: There was no significant difference among chronic kidney disease patients on hemodialysis, on conservative treatment and control healthy subjects regarding to salivary IgA while Salivary interleukin -6 and C- reactive protein was significantly higher in chronic kidney disease patients on hemodialysis and those on conservative treatment compared to healthy subjects.
Big Data y su importancia en la actualidad
Authors: Guerrero Luzuriaga Aura del Cisne
Published: June 2022

El universo digital ha ido evolucionando desde hace varias décadas. Desde 1948, cuando Claude Shannon creó la palabra byte para denominar la medida de una unidad de información, la sociedad a nivel mundial inició su incursión en este ámbito. Desde entonces, el camino ha sido largo, difícil, pero lleno de satisfacciones que van en beneficio del conocimiento y la automatización de procesos. En esta trayectoria se han gestado varios términos como big data, cloud computing, dataset, entre otros; todos ellos con un fin común, hablar sobre el manejo de grandes cantidades de información.
Land Tenure in Kerala and the Communist Agrarian Reform of 1958
Authors: Ajayan Thankappannair
Published: June 2022

Prior to its formation in 1956, the State of Kerala was divided into three regions: Malabar in the north, Cochin in the center, and Travancore in the south. These regions presented different types of land tenures and tenant conditions were worse in Malabar, which pertained to the British Empire, than in Cochin and Travancore. When Kerala became a State, most of the land was in the hands of a select few and tenants were frequently evicted. The Kerala Agrarian Relations Bill, piloted by the first communist ministry, sought to prevent this concentration and redistribute land to landless farmers. This legislation disproportionately affected Kerala’s major land-owning community of Nairs, and Mannath Padmanabhan, the leader of the Nair Service Society, organized a liberation movement to overthrow the Government. He worked in close collaboration with other aggrieved community organizations, including the Catholic Congress. In 1959, the struggle culminated with the dismissal of the communist ministry in Kerala by the Union Government, under Article 356 of the Constitution of India. Thus, the first-ever elected communist government in Asia came to an end.
Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
Authors: Pleininger Sonja , Indra Alexander , Golparian Daniel , Heger Florian , Schindler Stefanie , Jacobsson Susanne , Heidler Stefan , Unemo Magnus
Published: June 2022

We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia. Recommended treatment with ceftriaxone (1 g) plus azithromycin (1.5 g) possibly failed. Worryingly, this is the second strain in an Asian Neisseria gonorrhoeae genomic sublineage including high-level azithromycin-resistant strains that developed ceftriaxone resistance by acquisition of mosaic penA-60.001. Enhanced resistance surveillance and actions are imperative to prevent spread.
Yaşar Kemal’in Yer Demir Gök Bakır romanında mekânsal gösterim
Authors: GÜVEN Meriç , BAĞÇEVAN İsmail
Published: June 2022

Mekân dilbilimde zaman, kip, kişi gibi temel bir anlamsal kategoriyi ifade eder. Uzamsal varlıklar mekân içinde Gestalt psikolojideki şekil-zemin ilişkisine benzer bir ilişki aracılığıyla konumlanır veya yer değiştirirler. Şekil durumundaki somut varlıklar, merkezdeki konuşucunun yakınından uzağına doğru yayılan mesafelerde, mekânsal gösterime dayalı sistem aracılığıyla konumlanabilir. Mekânsal gösterimin merkezinde, zemin durumundaki konuşucu “ben” bulunur. Şekil durumundaki somut varlıklara işaret eden mekânsal gösterimler konuşucunun konumu ve kimliğine göre değişir. Bu değişimden dolayı konuşma olayının cereyan ettiği edimbilimsel bağlam mekânsal bilginin tayininde önem kazanır. Kurmaca bir metinde mekânsal gösterimi dilbilimsel yöntemlerle ele alan araştırmaların sayısı azdır. Dilsel ve dil-dışı bağlamın kesişim alanında yer alan mekânsal gösterim nedir? Mekânsal gösterim kodları nelerdir ve ne sıklıkla kullanılır? Türkçede dilbilgisel bir kategori olarak mekânsal gösterim nasıl kodlanır? Çalışmada bu ve benzeri sorulara cevap bulmak, literatüre kavramsal katkı sunmak ve tipolojik çalışmalara veri sağlamak amaçlanmaktadır. Bunun için Yaşar Kemal’in Yer Demir Gök Bakır adlı romanından seçilen, mekânsal gösterim içeren dört yüz on bir (n=411) maddelik örneklem incelenmiş ve sonuçlar betimlenmiştir. Buna göre, “kaynak”tan “hedef”e yönelik hareketi karşılayan gösterimsel fiiller iki yüz otuz (n=230) maddede ve merkeze yakın/uzak anlamlarını veren gösterimsel nominaller yüz seksen bir (n=181) maddede tespit edilmiştir. Mekânsal adlar hâl ekleri, iyelik ekleri ve son-edatlarla öbekleşebilir. Mekânsal gösterim bilgisi yalnızca sözcük, öbek ya da tümcelerden değil; daha yoğun ve doğru şekilde sözbirimlerden çıkarılır. Bu nedenle mekânsal gösterim üzerine yapılacak dilbilimsel çalışmalarda iletişim ortamının edimbilimsel bağlamına ve sözcelerdeki metindilbilimsel gönderimlere dikkat edilmelidir.
A growing dilemma: English speaking anxiety-in-EFL classrooms: A review of research
Authors: HÖL Devrim , KASIMİ Yusuf
Published: June 2022

The current study aims to discuss the current situation of research on speaking anxiety of EFL learners through some variables. The journals indexed in various databases were searched and 59 studies were selected for the review by considering (a) the participant selection process of the studies (b) the main causes of speaking anxiety in EFL classrooms (c) whether there is any difference according to some variables including level of proficiency, gender, and English learning background (d) how the participants perceive themselves in terms of speaking anxiety. It was found that the number of studies on speaking anxiety has been on the increase in the last decade. When it comes to the causes of speaking anxiety in the bunch of studies, the foremost and most reported cause of speaking anxiety is learners’ fear of making mistakes, being compared by others, proficiency level and gender type. As speaking one of the four skills to communicate in any language, it is important to find solutions to these questions and enhance the development of the EFL learners’ speaking skills. The findings yield important insights on Turkish EFL learners speaking anxiety in English for all the stakeholders ranging from teachers and learners. In addition, it is hoped that, from the sociological perspective, this paper will pave a way to rethink and criticize the local context in countries which do not include oral exams in their national standardized testing system and mandate receptive skills.
Video-accompanied vs. handout-accompanied assignments: Effects on EFL learners’ descriptive paragraphs
Authors: VALİZADEH Mohammadreza
Published: June 2022

This study compared the effects of videos and handouts, accompanied by the paragraph assignments, on the quality of English language learners’ written descriptive paragraphs. The study was quasi-experimental and quantitative. It had a pretest-treatment-posttest design. As the treatments, either videos or handouts were accompanied by descriptive paragraph assignments which the participating students were required to write. The purpose of accompanying either videos or handouts was providing the learners with additional guides to help them write appropriate and accurate descriptive paragraphs. The study was conducted during the Covid-19 crisis. The participants were 56 Turkish learners of English as a Foreign Language (EFL) at pre-intermediate level of proficiency. They were receiving virtual education due to school closures because of the Covid-19 pandemic. The participants were assigned to two groups, each of which included 28 learners. One group was provided with educational videos, relevant to the given assignment. The other group was given similar information via handouts. The results of the independent samples t-test indicated that the group that received videos significantly outperformed the one that received handouts. Consequently, the study highly recommends EFL teachers utilize this technique in their classrooms.