bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-awareness as the key to successful adherence to antiretroviral therapy among people living with HIV in Indonesia: A grounded theory study
Authors: Yona Sri , Edison Chiyar , Nursasi Astuti Yuni , Ismail Rita
Published: April 2023

Background: Adherence to antiretroviral therapy (ART) continues to pose a significant challenge for people living with HIV (PLWH). Non-adherence to ART can have far-reaching implications for patient well-being, particularly in increasing the risk of opportunistic infections when medication is not taken as prescribed.
Objective: This study aimed to develop a theoretical model that explains how PLWH in Indonesia adhere to their ART regimen and the strategies they follow to maintain adherence.
Methods: The study used a grounded theory approach. Data were collected through face-to-face in-depth interviews with 21 PLWH who had been taking ART for six months or more at a non-governmental organization (NGO) in Jakarta, Indonesia, between July 2019 and November 2019. Theoretical sampling was used, and the data analysis method of Corbin and Strauss was utilized, including open coding, axis coding, and selective coding.
Results: Three stages were identified as a process of adherence to the ART regimen: 1) initiating ART, 2) missing the connection, and 3) taking control. Self-awareness was identified as the central core theme describing the ART adherence process.
Conclusion: Having adequate self-awareness to take ART regularly is crucial to improving adherence to ART. Moreover, social support from one’s spouse and family members can help patients maintain adherence. Therefore, self-awareness and support systems should be included as components in nursing interventions when starting ART therapy. In addition, nurses can help identify potential support persons and provide information related to ART therapy.
Exploring the tuberculosis medication program in Indonesia as perceived by patients and their families: A qualitative study
Authors: Ritonga Imelda Liana , Setyowati Setyowati , Handiyani Hanny , Nursasi Astuty Yuni
Published: April 2023

Background: Tuberculosis (TB) remains a significant public health challenge in Indonesia, with the country experiencing one of the highest numbers of lost cases in TB management. Therefore, there is a need to identify the underlying reasons for this problem.
Objective: This study aimed to explore the experiences of TB-diagnosed patients and their families during the time of diagnosis and while undergoing the TB medication program.
Methods: This study employed a qualitative descriptive-interpretive approach. The study was conducted in government community health centers (CHC) from May 2022 to July 2022. A total of 22 participants, consisting of 12 TB-diagnosed patients and ten family members, were included in the study. Data were collected through focus group discussions and analyzed thematically.
Results: Five themes were developed: (1) Delay in tuberculosis diagnosis, (2) Delay in starting TB treatment, (3) High willingness of patients and their families to recover, (4) Understanding that TB is an infectious disease, and (5) Factors affecting patient recovery.
Conclusion: The study findings might contribute to the National TB elimination program. It is recommended that all health workers practicing in the community should be involved in the TB program to improve its management. Collaboration between multiple sectors in the community can also provide an advantage in solving TB problems by increasing new case detection. Additionally, it is suggested that all nurses working with TB patients establish rapport with health cadres and patients’ families to enhance medication adherence in patients.
Investigating the complex relationships between leadership, psychological safety, intrinsic motivation, and nurses’ voice behavior in public hospitals using PLS-SEM
Authors: Jaaffar Thuraisyah , Samy Naresh Kumar
Published: April 2023

Background: Voice behavior among nurses in public hospitals lacks profound disclosure despite knowing its imperatives. This situation needs to be continuously studied, and the best practices discovered, disclosed, and implemented in hospitals that are serious in curbing unprofessional conduct while advancing healthcare requirements for the benefit of humanity.
Objective: This empirical research investigated the significant implications of psychological safety and intrinsic motivation in the mostly uncultivated link concerning the empowering leadership style and leader-member exchange (LMX) constructs and the practice of voice behavior among nurses in the selected Malaysian public hospitals.
Methods: Primary data of the study were from nurses employed in the selected large public hospitals within the Klang Valley, also known as the Greater Kuala Lumpur of Malaysia. A total of 366 complete and valid responses were collected with the help of head nurses via a self-administered survey in February 2020. The SmartPLS 4 for Windows software generated the standard partial least squares structural equation modeling (PLS-SEM) to estimate associations between research variables and evaluate the model’s strength in explaining the proposed constructs.
Results: This research disproved the indirect effects of psychological safety on the connection explorations between empowering leadership-voice behavior (β = 0.015, t-value = 0.300, 95% CI [-0.090, 0.110]) and LMX-voice behavior (β = 0.002, t-value = 0.285, 95% CI [-0.014,0.020]). Intrinsic motivation partially mediates the link between empowering leadership-voice behavior (β = 0.214, t-value = 7.116, 95% CI [0.160, 0.279]) and LMX-voice behavior (β = 0.114, t-value = 4.669, 95% CI [0.071, 0.168]) of the nurses.
Conclusion:  Patients, non-governmental organizations, volunteers, nurses, and other hospital staff are vested in how voice behavior signifies in the healthcare context. Essential factors for nurses to become more outspoken are discovered in this study, providing nurse managers and other leaders with numerous recommendations for encouraging vocal behavior and bolstering psychological safety and intrinsic motivation. More competent nurses will improve workplace culture, deliver superior healthcare services, and manage publicly financed hospitals with an overall sense of trust, but only after a substantial effort to execute reforms.
Indicators of Microbiological Research in Mandibular Fracture
Authors: Apyshev Sh. , Alymbaeva A.
Published: April 2023

The state of the microflora in case of mandibular fractures was studied according to the data of the Department of Surgical Dentistry of the KSMA for 2021. A total of 34 patients were examined. In conclusion, it was concluded that the microbial flora is represented mainly in associations — 59.0% and 41.0% of cases - in monoculture. The most common microorganisms are Streptococcus constellatus, Actinobacillus actinomycetemcomitans, Staphylococcus hyicus. The isolated cultures of microorganisms were the most sensitive to gentamicin, amoxiclav, cefotoxime.
Features of Infusion Therapy
Authors: Satkeeva A.
Published: April 2023

The choice of life support parameters and maintaining the optimal intravascular volume of fluid, maintaining hemodynamic function during infusion therapy are one of the main components of the optimal therapeutic effect of an anesthesiologist-resuscitator. An analysis of the scientific literature has shown that for more than thirty years, disputes about the amount of fluid administered and the types of solutions during infusion therapy have not stopped. Until now, the question of the optimal intake of fluid, the volume of which will not lead to hypovolemia and impaired organ perfusion, remains open. The issue of generally accepted parameters and norms for “limited”, “dry” administration or “overload”, as well as the definition of parameters of central hemodynamics, remains under discussion. The question of recommendations on the choice between colloids and crystalloids still remains open. The main research methods were targeted analysis, comparison and generalization of information related to the optimization of diagnostic and treatment-and-prophylactic tactics in infusion therapy. The article presents an analysis of the problems of conducting infusion therapy. To date, recommendations on accounting for the volume of fluid administered during infusion therapy during thoracic and abdominal operations are contradictory. In the article, the author suggests options for the use of the quantitative and qualitative composition of the infusion during a planned operation, during the perioperative period, during abdominal operations, during thoracic operations, as well as features of infusion therapy in children and features of infusion therapy in obstetrics. The criteria for choosing colloids or crystalloids, formed on the basis of the correct interpretation of indicators corresponding to a specific clinical situation, are considered.
C-reactive Protein, Glomerular Filtration Rate, and Echocardiographic Parameters in Individuals With Different Cardiovascular Risk Categories
Authors: Murkamilov I. , Raimzhanov Z. , Sabirova A. , Duisheeva G. , Zhunusova D. , Satarova A. , Gasanov K. , Zakirov O. , Batyrbekov I. , Sabirov I. , Yusupov F. , Aidarov Z.
Published: April 2023

Despite the emergence of modern biomarkers, innovative methods of examination and treatment, the problems of cardiovascular risk in clinical medicine are still quite relevant. Widespread cardiovascular risk factors and high mortality from diseases of the circulatory system are observed in all countries of the world, including the Kyrgyz Republic thicknesses, relative LV wall thickness, LV myocardial mass, LV myocardial mass index, r. Aim of the study. To study the clinical and functional values of CRP and its relationship with cardiovascular risk factors in patients with chronic non-communicable diseases. Material and methods. The single-center open study included 290 people with different categories of cardiovascular risk, of which 150 men (51.7%), women - 140 (48.3%). All participants were analyzed hemodynamic parameters, indicators of clinical and biochemical parameters. The excretory function of the kidneys was assessed by the level of serum cystatin C. The glomerular filtration rate (GFR) was calculated according to the method of F. Hoek. The size of the left atrium (LA), the linear dimensions of the left ventricle (LV) were taken into account with an assessment of the structural modification of the myocardium. Depending on the concentration of CRP, two groups were formed: 1A and 1B. Results. In patients with high CRP levels, mean age, body mass index, heart rate, platelet, leukocyte, glucose, and cystatin C blood levels were significantly higher, and mean HDL cholesterol and GFR were significantly lower. Left atrial size, LV end-diastolic size, ventricular septal and posterior wall right ventricular E/A ratio, DT (deceleration time) LV, DT (deceleration time) of the right ventricle were significantly higher in the group of individuals with high levels of blood CRP. In patients with normal (1A) and elevated (1B) levels of CRP in the structure of changes in LV geometry, an eccentric variant of LV hypertrophy was significantly more often detected (74.9% and 66.0%, respectively). The blood CRP concentration was positively associated with the size of the left atrium and LV wall thickness, and negatively with the rate of GFR. Conclusion. In individuals with high and very high cardiovascular risk, elevated CRP levels are associated with more pronounced cardiovascular risk factors. In the group of patients with a high level of CRP, structural modification of the myocardium is represented significantly more often by an eccentric variant of LV hypertrophy.
Features of the Organization of Transportation of Goods by Rail From the Countries of the Pacific Region to Russia
Authors: Vydashenko L.
Published: April 2023

Currently, none of the modes of transport alone can satisfy all customer requests. For example, without the use of road transport, it will not be possible to deliver goods “from door to door”. An increase in the volume of multimodal transportation allows reducing the imbalance between different modes of transport and optimizing the transport system. Transportation from the Pacific region is especially relevant at the present time, since this region is a reliable partner of Russia during the introduction of new sanctions by the European Union. And the active development of the Pacific region. In this paper, the transportation of goods in containers will be considered, since the container transportation market shows a positive trend every year. The purpose of this work was to develop an optimal route for transportation from India.
Dynamics of Development of the Agricultural Sector of the Russian Economy in 2022
Authors: Smirnov V.
Published: April 2023

The article presents an analysis of the state of the agricultural sector of the Russian economy, which showed growth to record values. The maximum share in the agricultural sector is accounted for by the production of grain and leguminous crops. The leaders in production are the Krasnodar Territory, the Rostov Region and the Stavropol Territory.
Implementation of the Standards of the International Conventions Regarding Child Labor Into Uzbekistan Laws
Authors: Kallibekov T. , Berdimuratova G.
Published: April 2023

In this article, children defined in the Conventions on the Minimum Age for Employment adopted by the International Labor Organization on June 26, 1973 and on the Worst Forms of Child Labor adopted on June 17, 1999 the implementation of labor regulations into the Labor Code of the Republic of Uzbekistan is discussed. Article has the high scientific and practical value as is modern attempt of consideration of an actual problem. The article deals with the formation and implementation of legislative and implementation guarantees and mechanisms for the prevention and prevention of child labor in the Republic of Uzbekistan.
Ways of Educational Sector Legal Development in the Kyrgyz Republic
Authors: Shookumova D. , Paraidin u.Sh. , Mamatova A. , Amirova K. , Utanov K. , Ibraimov B.
Published: April 2023

The study of legal development ways of education sector in the Kyrgyz Republic is an urgent task in the recent time. Research objectives: analysis and study of legal development ways of the education sector in the Kyrgyz Republic. Research materials and methods: a literary review was made on legal aspects and regulatory laws in the development of the education sector in the Kyrgyz Republic. Research results:legal acts containing administrative and legal norms regulating relations in the field of higher education interact with each other in accordance with general patterns. Conclusions:there is a need to correct domestic legislation by introducing amendments and additions to the laws governing administrative relations in the field of education and science.
Definition of the Concept and Signs of Prostitution: Problematic Aspects in Theory and Legal Practice
Authors: Minster M. , Pavlovsky I.
Published: April 2023

The article discusses the definition of the concept of “prostitution” and the characteristics of some signs that allow to distinguish prostitution from other sexualized forms of deviant behavior. Based on the results of the research of scientific works in modern criminology and criminal law, as well as the analysis of the criminal legislation of the Russian Federation and judicial practice, the following conclusions are made. The problems of understanding this term are that the law does not establish a clear definition of it, and for legal practice it is important, because in Russian legislation, the concept of “prostitution” is used in the construction of several dispositions of the norms of the Criminal Code of the Russian Federation and the Administrative Code of the Russian Federation and delineation from other elements of crimes and criminally non-punishable actions. In addition, the features of the subject of prostitution and its specific perception by the legislator in the problematic aspect are considered. In the conclusion of the article, taking into account the essence and signs of prostitution, a definition of the concept of “prostitution” is developed and a two-tier classification of signs of prostitution is formulated.
Personal and Social Balance as a Result of Self-understanding of “I-Identity”
Authors: Kamchybek uulu M.
Published: April 2023

This article is devoted to the analysis of research and study of self-understanding in psychology. New approaches to this problem are highlighted and a theoretical analysis of the self-understanding of “I-Identity” is reflected. It also examines the methodological foundations and problems of studying self-understanding both within the Western and Russian traditions of studying the phenomenon of “self-understanding”, a comparative analysis of these definitions is carried out, with the allocation of the category of “I” (I as a construct) and the phenomenon of “Self” / “Selbst” / self and self (English / German / Russian as a pronoun and as a noun) in order, based on the conditional differentiation of the concepts of “I” and “Myself”, to theoretically substantiate and meaningfully reveal the integral phenomenon of “self-understanding of Self-Identity” as a result of finding a balance between personal and social identities of a person in modern society.
Universal Human Values in When the Mountains Fall Novel by Chinghiz Aitmatov and Their Pedagogical Analysis
Authors: Baitokova A.
Published: April 2023

The article reveals one of the urgent problems of teaching and shaping the current young generation in the right direction. In particular, the article considers the issue of When Mountains Fall novel by Ch. Aitmatov, which notes the importance of values and their place in human life in the context of globalization. The great thinker’s novel describes in detail the changes in values in people's lives with the advent of a market economy. As society develops, the character and consciousness of people change, and at the same time spiritual values are pushed aside. This issue is not limited to the review of literature, but a pedagogical analysis of the values in the novel is proposed using the method of content analysis within the framework of scientific pedagogy. The relevance lies in the fact that, especially at the present time, it is necessary to carefully and attentively address the issues of upbringing and education of the younger generation.
Methods of Drawing Portrait Genre in Fine Arts
Authors: Mammadova A.
Published: April 2023

Art is one of the forms of social expression, and it was created as a result of visualizing the images created in human thinking, emotions and abstract thought by means of images. The images created as a result of the impact of the external world surrounding a person, the processes and events occurring in it on feelings and thinking are the basis of image creation. Portrait painting, which reflects a person’s inner world, feelings and emotions through facial expressions, lines, likeness and mimicry, eyes and gaze, which are considered as a mirror of mood, is considered a very complex genre of fine art and painting. The portrait genre, which is one of the main genres of painting and graphics, has taken a very wide place in fine arts. As in other genres, portrait works take their content from public life and reflect public existence through specific artistic images and influence public life. Therefore, the portrait artist is not satisfied with giving only external signs of a person in his works, such as external resemblance, pose, movement and facial expressions. At the same time, the tries to show the spiritual world, psychological characteristics and what kind of character the person he paints.
Interrelation of Creative Competence and the Process of Analysis of Literary Text in Lessons of Literary Reading
Authors: Mamyrova A. , Kurbanalieva G.
Published: April 2023

The main goal of teaching literature is to prepare a creative reader, and for this, the work of analyzing each text should be aimed at solving these problems. This article presents the relationship between the theoretical concept of creativity, creative competence and the analysis of a literary text. The significance of pedagogical experience lies in the fact that today it is necessary to harmoniously combine educational activities, within which basic knowledge, skills and abilities are formed, with creative activities associated with the development of individual inclinations of students, their cognitive activity. In the last decade, interest in the literary education of younger schoolchildren has increased significantly. A new view of the initial link has taken root in the pedagogical community, it is now rightly considered not only as a preparatory stage preceding secondary education, but also as an age that is characterized by meaningful cognitive activity. Literary artistic text is one of the main means of improving the creativity of students, so special attention is paid to the work on text analysis. The relevance of the article lies in the fact that for the first time it considers the problem of developing the creative competence of students in the process of analyzing a literary text. The ideas presented in the article will help to improve the technology of teaching primary school teachers in the lessons of literary reading.
Pedagogy of Higher Professional Education in Kyrgyzstan and Methodological Principles of Formation of Students’ Career-oriented Identity
Authors: Bekmatova Zh. , Toktosunova Z.
Published: April 2023

The article discusses the methodological principles of teaching necessary for the successful implementation of communication skills in English by mathematics students. Currently, relevant views that play an important role in the development of professional communication skills of mathematics students have found a place in the newly adopted standard of higher mathematical professional education in Kyrgyzstan, and the goal of its implementation is proposed as a direct methodological principle. in the learning process can be analyzed. The article convincingly explains with examples what methodological principles should be based on in order to achieve the desired result in teaching English. It is reliably interpreted that the questions necessary for the proper organization of professional communication in English by mathematics students will be effective only if they are formulated on the basis of methodological principles derived from many years of experience.
Study of Stable Social Relations in the Family in the Works of Eastern Thinkers
Authors: Yulchieva D.
Published: April 2023

In this article, since ancient times, advanced persons in society, scientists, scholars and sages have paid particular attention to the issues of family and marriage. Abu Raikhan Beruni, Abu Ali ibn Sina, Abu Nasr Farabi, Yusuf Khos Hajib, Kaykovus, Alisher Navoi, Abdullah Avloni, Abdurauf Fitrat, many great scholars and scientists of the East left behind many scientific and practical ideas about raising a well-rounded person in their family and family social relations. These ideas are great importance for modern science and practice. Eastern thinkers of the past emphasized the importance of the family and family education in the maturity and development of a well-rounded person. In particular, they paid special attention to the fact that interpersonal relations in the family, the moral formation of the father and mother have a special place in the upbringing of the child, that the integrity and harmony of the family depend on all the family members. The Avesta, a book of Zoroastrianism written 2700 years earlier, states that the family is a sacred place, and that husbands and wives are equally responsible for the stability of family relations, especially in raising children. The following is said about what depends on the peace and well-being of the family: “Porso, if a person restore a house and allocates a place for fire, his family, his wife and children, if his house is filled with good things and his wife and children live comfortably, if there is faith, constant fire, and other things in abundance in his house, that address is respectable”. At the same time, it is explained that what should be paid special attention to ensure positive and stable relations in the family. According to the Avesta, it is better for the father to be the leader in the family.
Pronouns in the Communicative-Discursive Aspect as an Object of Study in a Modern Language University
Authors: Atakulova M. , Abdykadyrova S. , Tashieva N.
Published: April 2023

The purpose of this work is to briefly characterize the features of the functioning of some personal pronouns in the Kyrgyz language from the point of view of a communicative approach to speech. The authors of this work made an attempt to consider the linguistic problems of the pronouns of the Kyrgyz language and present them in the descriptions of the pronominal words of the Kyrgyz language. The study states that each pronoun has a lexical meaning, which is fixed lexicographically. The categorical-grammatical meaning of pronominal words is egocentrism, around which the entire demonstrative field is grouped. In the work, egocentrism is defined as the categorical meaning of pronominal lexemes. Their semantics is abstract. And objectivity and distinction are the exclusive categorical meanings of pronominal lexemes that characterize their types and subspecies.
Some Issues of the Study of Language Gaps in the Field of Kyrgyz Linguistics
Authors: Karataeva G.
Published: April 2023

The article deals with some issues related to one of the important problems in the field of translation theory, namely the theory of gaps. In particular, some concepts proposed by linguists in the field of Kyrgyz linguistics regarding theoretical models and methods for adequate translation of non-equivalent vocabulary are considered. At the same time, the problems associated with the principles of classification of lacunae, which remain little studied problems to date, are analyzed. In accordance with the theoretical problems under consideration, language illustrations were given, in which there are gaps, which were translated from Kyrgyz into Russian, by using different methods. In particular, on the example of specific linguistic facts, such methods of translating lacunae as elimination, compensation, transcription, transliteration, tracing, descriptive translation, creation of analogue correspondences, concretization and generalization are considered.
Russian Native - Maga Rahmani: The First Female Writer of Afghanistan and Her Tadhkirats
Authors: Tuychiyeva O.
Published: April 2023

This article discusses about Maga Rahmani who native Russian woman from Afghanistan was and who wrote very meaningful tadhkirats. Maga Rahmani was very first woman scholar who got involved in creative research. Her works contain much valuable information and facts concerned with the system of government in Mavarannahr, Iran, Afghanistan, and India. Also, some of her tadhkiras is an important source in studying the issues related to the Baburid period and the role of princesses in public policy and literature. The information provided by Maga Rahmani serves as an important source in covering the reforms carried out to improve the governance of the period, and in evaluating the poetry and art of the period under study. In her tadhkirat, Maga Rahmani focuses on the Baburids, mainly on the life and work of Akbarshah, Jahangir Mirza, Shah Jahan, and the queens of that period, Gulbadan Begim, Nurjahon Begim, and Zebunniso Begim. In turn, the tadhkirat of “Pardaneshinone suhanguy” is very valuable in studying the role of Baburi and Timurid princesses in public policy. This article research about life, works, activities of Maga Rahmani as well as the information can be obtained or felt about the political system, economical condition and cultural lifestyle of Afghanistan in XX century’s first half part.
Representasi Keindahan dan Keheningan dalam Wajah Iklan Pariwisata Indonesia di Era Pandemi Covid-19: Analisis Retorika Visual
Authors: Hartanto Arief
Published: April 2023

AbstrakDampak dari pandemi covid-19 pada sektor pariwisata telah terjadi krisis multi dimensi baik secara materiil dan non materiil. Keberadaan iklan bisa menjadi media komunikasi visual untuk merespon kondisi yang terjadi. Tujuan penelitian pada artikel ini untuk menggali makna dan pesan dari iklan pariwisata Indonesia, serta untuk mengetahui respon audien terhadap iklan tersebut yang ada di media Youtube. Penelitian ini menggunakan metode kualitatif. Pengambilan data melalui observasi visual, dokumentasi dan menggunakan aplikasi daring netlytic untuk mengambil data respon audien yang terdapat di iklan tersebut. Analisis menggunakan teori perspektif retorika visual dari Foss, dan menggunakan aplikasi daring netlytic untuk melakukan analisis teks dari respon audien. Hasil penelitiannya yaitu diketahui bahwa secara keseluruhan bentuk visual yang dihadirkan pada iklan ini berupa visual yang diam dan menghadirkan visual tentang keindahan objek pariwisata alam yang dimiliki Indonesia. Bentuk visual ini merepresentasikan keindahan dan keheningan yang kemudian merujuk pada peristiwa dan kondisi krisis yang sedang dihadapi. Audien juga mengapresiasi secara kualitas dari iklan pariwisata Indonesia ini baik secara teknis pengerjaan dan materi visual yang ada. Kata kunci: analisis teks, covid 19, iklan, pariwisata, retorika visual                AbstractThe impact of the Covid-19 pandemic on the tourism sector has resulted in a multi-dimensional crisis, materially and non-materially either. The existence of advertising can be a medium of visual communication to respond to the occurring conditions. The research purpose of this article is to explore the meaning and the message of Indonesian tourism advertisements as well as find out the audience's response to these advertisements on YouTube media. This study uses a qualitative method. Data was collected through visual observation, documentation, and then using the netlytic online application to retrieve audience response to the data contained in the advertisement. The analysis uses Foss theory of visual rhetorical perspective and the netlytic online application to carry out text analysis of audience responses. The results of his research are shown that overall the visual form presented in this ad is the form of a still visual and presents the visual beauty of Indonesia's natural tourism objects. This visual form represents beauty and serenity which then refers to the events and conditions of the crisis being faced. The audience also appreciates the quality of this Indonesian tourism advertisement technically and in the existing visual materials either. Keywords: advertising, covid-19, texts analysis, tourism, visual rhetoric
Koherensi Lintas Moda sebagai Upaya untuk Meningkatkan Kualitas Buku Digital Dwibahasa Budhara (Borobudur Dalam Hamparan Cerita)
Authors: Mulatsih Sri , Nugroho Raden Arief , Suryaningtyas Valentina Widya , Soerjowardhana Aloysius , Muqoddas Ali , Udayanti Erika Devi
Published: April 2023

Abstrak Sebagai upaya untuk meningkatkan kualitas informasi pariwisata Candi Borobudur dan Kawasan Cagar Budaya Borobodur, para peneliti membuat sebuah buku digital yang dinamai Budhara (Borobudur dalam Hamparan Cerita). Budhara dikembangkan dengan menggunakan metode Multimedia Development Life Cycle (MDLC). Buku digital ini dilengkapi dengan fitur-fitur, seperti navigasi, manipulasi, kontrol, pencarian, dan dialog.  Karena adanya perbedaan perilaku berwisata antara wisatawan lokal dan mancanegara, tim peneliti membedakan visual atau gambar di halaman Budhara berbahasa Indonesia dan Inggris. Terlepas dari perbedaan tersebut, tim peneliti harus mempertahankan koherensi informasi visual dan teks tulisnya dari buku digital ini, karena hal ini dapat mempengaruhi indeks kepuasan wisatawan. Kata Kunci: Budhara, Buku Digital, Candi Borobudur, Koherensi Lintas Moda, Pariwisata  AbstractAs an effort to improve the quality of tourism at Borobudur Temple and Borobudur Cultural Heritage Area (Kawasan Cagar Budya Borobudur), the researchers designed a digital book entitled Budhara (Borobudur dalam Hamparan Cerita). Budhara was designed using Multimedia Development Life Cycle method (MDLC). This digital book is equipped with features, such as navigation, manipulation, control, search, and dialog. Due to dissimilar travel behavior between domestic and international tourists, the researchers differentiate the visualization or pictures in Budhara’s Indonesian and English pages. Apart from the difference, the researchers must employ cross-modal coherence of Budhara’s visual information and its written one, in view of the fact that it can impact the tourist satisfaction index.  Keywords: Budhara, Digital Book, Borobudur Temple, Cross-modal Coherence, Tourism
Network Pharmacology-Based Validation of Traditional Therapeutic Claim of Momordica Charantiain Alleviating Diabetic Nephropathy
Authors: Gautam Gaurav
Published: April 2023

For centuries, medicinal plants have been playing an important role in the alleviation of various diseases, traditionally. Momordica charantia L. (M. charantia) is a folk medicinal herb belong to the Cucurbitaceae family, used as the folk medicinal regime for the treatment of diabetes or diabetic nephropathy (DN), traditionally. Due to the lack of scientific evidence based on its molecular mechanism for treating DN, the study is aimed to investigate the molecular mechanism of M. charantia metabolites using a network pharmacology approach. Furthermore, ADME analysis was performed to determine the lipophilicity and the drug-likeness response of the metabolites. The network pharmacology results showed a multi-mechanistic and therapeutic role of the metabolites present M. charantia by regulating several genomes involved in the pathophysiology of DN. Mean while, M. charantia ameliorates endothelial dysfunction, fatty liver disease, diabetes mellitus, acute kidney injury, fibrosis, hypertensive disease, obesity, etc. furthermore, it was also found that the targets potentially play an essential role in the regulation of oxidative stress, inflammation, and oxidative stress-induced inflammation. In ADME analysis, each selected molecule of M. charantia exhibited good gastrointestinal (GI) absorption, lipophilicity and bioavailability response. Hence, it can be demonstrated that M. charantiapossesses several metabolites including polyphenols which exhibit an important role in the treatment of DN via regulation of several genomes such as AKTs, CASPs, MAPKs, ILs, NOs, etc, responsible for its pathophysiology. Furthermore, the generated evidence validates the traditional claim of M. charantia for alleviating DN.
Adverse Childhood Experiences: Piloting a Group Therapy Program Using Psychoeducation, Music Therapy, and the Creative Arts for Adults with Complex Concurrent Disorders in an Inpatient Setting
Authors: Kirkland Kevin
Published: April 2023

Research shows a significant correlation between adverse childhood experiences (ACEs) and later adult mental health and addiction issues. There is currently no literature on therapeutic interventions to begin to redress their complex issues. Mental health, psychiatric, and addiction treatment centers often avoid tackling the manifold roots of dysfunction in clients' lives. We present the implementation of group therapy for clients with significant ACE histories, inspired by an initial in-service for clients on the subject of ACEs in mental health and addictions. Establishing group therapy for a broad spectrum of adverse childhood events proved to be an ambitious yet rewarding task. We discuss developing a comprehensive curriculum with a psychoeducational focus, a trauma-informed lens to support symptom management and resilience, and expressive elements by incorporating music therapy and the creative arts because of emerging evidence of the need for trauma recovery to engage in expressive and embodied outlets. Group observations and anecdotal evidence from clients' evaluations of the group support the urgent need for moving from research findings on ACEs to the implementation of group therapy.
Vem får skriva?
Authors: Edberg Anna
Published: April 2023

Hej! Jag är en student på kandidatprogrammet Språk, litteratur och medier från Linköpings Universitet som gör ett projektarbete om den etniska mångfalden bland Sveriges bästsäljande författare!
Mångfald och inkludering pratas det mycket om i samhället, på arbetsplatser och inom litteratur. Ett viktigt arbete som fortfarande har långt att gå. Jag har sett över hur den svenska bokmarknaden har sett ut 2022 och kunde snabbt se att mångfaldsarbetet inte verkar ha nått författaryrket.
Som del av mitt arbete har jag skapat bloggen “Vem får skriva?” för att redogöra för situationen idag. Det har jag gjort genom statistik, representationens betydelse för samhället och en reflektion över mina egna läsvanor.
Sympathetic and hemodynamic responses to exercise in heart failure with preserved ejection fraction
Authors: Manabe Kazumasa , D’Souza Andrew W. , Washio Takuro , Takeda Ryosuke , Hissen Sarah L. , Akins John D. , Fu Qi
Published: April 2023

Excessive sympathetic activity during exercise causes heightened peripheral vasoconstriction, which can reduce oxygen delivery to active muscles, resulting in exercise intolerance. Although both patients suffering from heart failure with preserved and reduced ejection fraction (HFpEF and HFrEF, respectively) exhibit reduced exercise capacity, accumulating evidence suggests that the underlying pathophysiology may be different between these two conditions. Unlike HFrEF, which is characterized by cardiac dysfunction with lower peak oxygen uptake, exercise intolerance in HFpEF appears to be predominantly attributed to peripheral limitations involving inadequate vasoconstriction rather than cardiac limitations. However, the relationship between systemic hemodynamics and the sympathetic neural response during exercise in HFpEF is less clear. This mini review summarizes the current knowledge on the sympathetic (i.e., muscle sympathetic nerve activity, plasma norepinephrine concentration) and hemodynamic (i.e., blood pressure, limb blood flow) responses to dynamic and static exercise in HFpEF compared to HFrEF, as well as non-HF controls. We also discuss the potential of a relationship between sympathetic over-activation and vasoconstriction leading to exercise intolerance in HFpEF. The limited body of literature indicates that higher peripheral vascular resistance, perhaps secondary to excessive sympathetically mediated vasoconstrictor discharge compared to non-HF and HFrEF, drives exercise in HFpEF. Excessive vasoconstriction also may primarily account for over elevations in blood pressure and concomitant limitations in skeletal muscle blood flow during dynamic exercise, resulting in exercise intolerance. Conversely, during static exercise, HFpEF exhibit relatively normal sympathetic neural reactivity compared to non-HF, suggesting that other mechanisms beyond sympathetic vasoconstriction dictate exercise intolerance in HFpEF.
The student response on the use of renewable energy graphical interface simulator in learning environment
Authors: Gopabala Krishnan Lavaniya , Albani Aliashim , Segar Yogesswary , Ridzuan Abdul Rahim , Ismail Mohd Khairi , Musa Mohd Azlan , Gunaseelan Khemaalatha , Subramaniam Tamil Selvan , Ibrahim Mohd Zamri
Published: April 2023

Introduction

The purpose of this study is to evaluate students’ responses regarding the usefulness of a graphical user interface (GUI) tool in the context of their respective learning environments. The Energy Computator GUI (EC-GUI) helps to simplify the STEM student’s learning processes. The EC-GUI serves as a simulator that can assist in computing formulas, designing graphs, acting as a unit converter, and automatically deriving parameters.

Methodology

Furthermore, a survey, which included closed and open questions, was carried out on a selection of students majoring in STEM subjects at Universiti Malaysia Terengganu (UMT) who were enrolled in the Renewable Energy course. A total of 54 respondents participated in the survey and 90.8% of them expressed satisfaction with the EC-GUI provided. The research involved using two distinct kinds of analysis: a parametric analysis, the paired sample t-test, and a non-parametric analysis, the Wilcoxon signed-rank test.

Results

The study findings indicated that the majority of the respondents felt that the difficulty level of the subjects did not change after using the EC-GUI. However, it helped to simplify the learning process for students in STEM fields. The p-value of the appropriate teaching aid tool was less than 0.05, indicating that the results were significant both before and after using the EC-GUI.

Conclusion

The study suggests that a similar GUI tool could be implemented in Malaysia’s teaching and learning processes as it is easy to build and use.
Metaverse for education – Virtual or real?
Authors: Hussain Sajjad
Published: April 2023

Metaverse is considered an extension of the Internet that is expected to revolutionize our social and economic lives by offering seamless interactions in the virtual worlds. Some believe that the Metaverse is one of those technologies that are destined to fail while others envisage Metaverse as part and parcel of future life, same as the Internet in today’s world. While the jury is still out on whether the Metaverse would eventually be materialized to its full potential, billions have been invested into to the development of the Metaverse and its related technologies by the technology giants such as Meta, Microsoft, and Apple. The Metaverse promises to bring a step change in every walk of life and Education sector is no exception. A true realization of the Metaverse will make the geographical boundaries disappear making the education accessible to the least privileged communities. At the same time, the virtual worlds with immersive experiences of usually less accessible resources would provide at-scale resource sharing throughout the world. The Metaverse would enable seamless access of Stanford labs, for instance, to someone in Africa to do collaborative experiments in the virtual worlds. This Perspective presents the status of the Metaverse in Education. It describes the future of Education sector with the integration of the Metaverse. In the end it presents the author’s perspective on the practicalities and challenges of the Metaverse in Education. The author believes that despite all the hype created around Metaverse, it will take a pandemic-like disruption for the academic world to truly embrace and integrate the Metaverse in Education sector.
Predictive model of diabetes mellitus in patients with idiopathic inflammatory myopathies
Authors: Nie Qiong , Qin Li , Yan Wei , Luo Qiang , Ying Tao , Wang Han , Wu Jing
Published: April 2023

Objectives

Cardiovascular diseases are the common cause of death in patients with idiopathic inflammatory myopathies (IIMs). Diabetes mellitus was associated with higher cardiovascular mortality, but few studies focused on the risk of diabetes mellitus in IIMs patients. Our study is aimed at developing a predictive model of diabetes mellitus in IIMs patients.

Methods

A total of 354 patients were included in this study, of whom 35 (9.9%) were diagnosed as new-onset diabetes mellitus. The predictive nomogram was drawn based on the features selected by least absolute shrinkage and selection operator (LASSO) regression, univariate logistic regression, multivariable logistic regression, and clinical relationship. The discriminative capacity of the nomogram was assessed by C-index, calibration plot, and clinical usefulness. The predictive model was verified by the bootstrapping validation.

Results

The nomogram mainly included predictors such as age, gender, hypertension, uric acid, and serum creatinine. This predictive model demonstrated good discrimination and calibration in primary cohort (C-index=0.762, 95% CI: 0.677-0.847) and validation cohort (C-index=0.725). Decision curve analysis indicated that this predictive model was clinically useful.

Conclusions

Clinicians can assess the risk of diabetes mellitus in IIMs patients by using this prediction model, and preventive measures should be taken early for high-risk patients, ultimately reducing the adverse cardiovascular prognosis.
Hyperglycemia-induced oxidative stress and epigenetic regulation of ET-1 gene in endothelial cells
Authors: Binjawhar Dalal Nasser , Alhazmi Alaa T. , Bin Jawhar Wejdan Nasser , MohammedSaeed Walaa , Safi Sher Zaman
Published: April 2023

Introduction: Hyperglycemia-induced endothelial dysfunction and the subsequent increase of oxidative stress could lead to aberrant regulation of various genes which are responsible for a range of functions. This study aims to find out how hyperglycemia affect oxidative stress and then the expression and methylation of endothelin 1 (ET-1) gene in in human umbilical vein endothelial cells (HUVEC).

Methods: Cells were cultured in growth medium and exposed to low and high glucose concentrations to mimic normal and diabetic condition respectively. Computational analysis were performed using UCSC genome browser and eukaryotic promoter database (EPD). The expression of ET-1 gene was investigated by real time PCR. Cytotoxicity and oxidative stress were determined by MTT and DCFH-DA assays respectively. Promoter methylation was assessed by the bisulfite sequencing method.

Results: DCFH-DA assay showed that hyperglycemia can significantly increase the regulation of reactive oxygen species synthesis. The relative expression of ET-1 gene was increased due to exposure to high glucose concentration. MTT assay revealed reduced viability of cells due to the glucose induced damage. Methylation analysis revealed hypomethylation of the promoter of ET-1 however the difference was not significant. Out of 175 CpGs at 25 CpG sites, only 36 CpGs were methylated (20.5% methylation) in cell treated with normal glucose. Upon exposure to high glucose only 30 CpGs were methylated in 175 CpGs at 25 CpG sites (17.1% methylation).

Discussion: Our study concludes a significantly high expression of ET-1 gene in response to high glucose exposure in HUVECs. It also reports that hyperglycemic condition leads to elevated oxidative stress. No significant change was found in methylation when cells were treated with high and low glucose concentrations.
Immune correlates of protection for SARS-CoV-2, Ebola and Nipah virus infection
Authors: Escudero-Pérez Beatriz , Lawrence Philip , Castillo-Olivares Javier
Published: April 2023

Correlates of protection (CoP) are biological parameters that predict a certain level of protection against an infectious disease. Well-established correlates of protection facilitate the development and licensing of vaccines by assessing protective efficacy without the need to expose clinical trial participants to the infectious agent against which the vaccine aims to protect. Despite the fact that viruses have many features in common, correlates of protection can vary considerably amongst the same virus family and even amongst a same virus depending on the infection phase that is under consideration. Moreover, the complex interplay between the various immune cell populations that interact during infection and the high degree of genetic variation of certain pathogens, renders the identification of immune correlates of protection difficult. Some emerging and re-emerging viruses of high consequence for public health such as SARS-CoV-2, Nipah virus (NiV) and Ebola virus (EBOV) are especially challenging with regards to the identification of CoP since these pathogens have been shown to dysregulate the immune response during infection. Whereas, virus neutralising antibodies and polyfunctional T-cell responses have been shown to correlate with certain levels of protection against SARS-CoV-2, EBOV and NiV, other effector mechanisms of immunity play important roles in shaping the immune response against these pathogens, which in turn might serve as alternative correlates of protection. This review describes the different components of the adaptive and innate immune system that are activated during SARS-CoV-2, EBOV and NiV infections and that may contribute to protection and virus clearance. Overall, we highlight the immune signatures that are associated with protection against these pathogens in humans and could be used as CoP.