bluuebunny/crossref_metadata_2025 huggingface dataset:
Breaking the silence: The role of extracellular vesicles in unraveling the diagnosis and treatment of endometriosis
Authors: Utkarsh Kumar , Srivastava Namita , Papayannakos Christopher , Nayyar Ashima , Khan Azhar , Haque Shabirul
Published: December 2023

Cell-to-cell communication is believed to be facilitated by membrane-bound vesicles called extracellular vesicles (EVs), which are released by cells. Protein, lipids, and nucleic acids are major cargo of EVs and are transported in these vesicles. Depending on the parent and recipient cell types, they can affect a wide variety of biological processes in the tissues to which they are delivered. EVs are essential for embryo implantation and endometriosis, and they are located in the uterine cavities of different species, where they promote blastocyst and endometrial preparation for implantation. This review focuses on what is currently understood regarding pathologic and diagnostic characteristics, and the potential therapeutic value of EVs in the context of endometriosis, where they can be used for drug delivery and targeted therapy due to their ability to carry bioactive molecules to specific cells or tissues. The findings of this review highlight the potential for a wide range of clinical applications that involve endometrial EVs in the areas of treatment, such as surgical and pharmacological, diagnostic biomarker development, and drug delivery systems, all with the ultimate goal of improving pregnancy success rates.
Targeting KIR as a novel approach to improve CAR-NK cell function
Authors: Graham Lara V. , Fisher Jack G. , Khakoo Salim I. , Blunt Matthew D.
Published: December 2023

Chimeric antigen receptor (CAR) NK cells are demonstrating promising activity in clinical trials and possess a favorable safety profile compared to CAR-T cells. The Killer cell Immunoglobulin-like Receptors (KIR) have a critical role in the control of NK cell function, and recently, this family of activating and inhibitory receptors have been targeted to improve CAR-NK function. These strategies include the utilisation of inhibitory KIR to reduce trogocytosis-associated NK cell fratricide, the downregulation of inhibitory KIR on CAR-NK cells to alleviate HLA mediated suppression, the selection of CAR-NK cell donors enriched for activating KIR, and the use of activating KIR intracellular domains within novel CAR constructs. These pre-clinical studies demonstrate the potential utility of targeting the KIR to improve CAR-NK cell efficacy and patient outcomes.
KEANEKARAGAMAN PLANKTON DAN HUBUNGANNYA DENGAN KUALITAS AIR SUNGAI SEKITAR PABRIK KELAPA SAWIT (STUDI KASUS DI ASAM-ASAM, JORONG KABUPATEN TANAH LAUT)
Authors: Dzikrina Dhia , Rahman Mijani , Akbar Arief R. M. , Yunita Rizmi
Published: December 2023

The Asam-Asam  River is one of the waters located in Tanah Laut Regency and is in an oil palm plantation area which is very close to the Palm Oil Mill (PKS). The Asam-Asam  River has an important role for the surrounding community who use these waters as a source of water for the community around fishing activities, domestic activities such as washing clothes and supplying water for oil palm plantations. Water from PKS activities is thought to have changed the condition of the waters of the Asam-Asam  river, therefore identification of plankton diversity in the Asam-Asam  River was carried out and data collection of water quality parameters (pH, temperature, DO, BOD, COD, Nitrate and Phosphate) as supporting data for the identification results plankton. This research was conducted in August 2021. Observation points and water sampling were carried out at 2 stations in the Asam-Asam  River. The supporting parameters observed were pH, temperature, DO, BOD, COD, nitrate and phosphate. Station II had the highest abundance of phytoplankton because the presence of the genera Oscillatoria, Tablelaria and Spirogyra was much higher than Station I. In the results of the two observation stations, the class Bacillariophyceae was the most common.
IDENTIFIKASI, EVALUASI DAN REKOMENDASI LAYANAN LUMPUR TINJA DI KOTA BANJARBARU KALIMANTAN SELATAN
Authors: Maimunah Maimunah , Mahreda Emmy Sri , Prihatini Nopi Stiyati , Mahmud Mahmud
Published: December 2023

The feces waste treatment installation (IPLT) pond capacity of Banjarbaru is 20 M3/ day, while the maximum amount per month in 2022 is only 11 M3 of household fecal waste that goes into IPLT. This shows that the excrement that enters the IPLT is below the IPLT capacity of Banjarbaru because currently, the sludge service has yet to be scheduled and is still using the on-call system. Meanwhile, Banjarbaru Regional Regulation No. 1 of 2021 regarding scheduled sludge services in Banjarbaru already exists. This study aims to identify and evaluate the existing conditions of the sludge service in Banjarbaru and develop recommendations for improving the sludge service in Banjarbaru. The method used in this research is a descriptive method using a questionnaire and conducting interviews with people who have used sludge services in 2022. Calculation of the results of the questionnaire uses a Likert scale, validity, and reliability tests. The results of the identification through the questionnaire revealed that the IPLT had been actively carried out with the on-call system; if implementing the scheduled feces sludge service (LLTT), several processes had to be improved, and the results of the evaluation stated that the community did not agree with the fees charged for the LLTT. Recommendations for sludge services are increasing the number of fleets, promoting sludge services, and improving the administration system.
ANALISIS ESTIMASI LAJU EROSI DI DAS MALUKA PROVINSI KALIMANTAN SELATAN DENGAN MODEL E30
Authors: Ilmi Zainal , Badaruddin Badaruddin , Suyanto Suyanto , Fithria Abdi
Published: December 2023

Problems in the Maluka watershed such as flood disasters are an indication that the management of the Maluka watershed still needs continuous and targeted improvement, one indication of the cause of the flood problem is the high rate of erosion in the Maluka watershed, several studies have been conducted in parts of the Maluka watershed area, but comprehensive erosion rate data in the Maluka watershed area still does not exist so that this Erosion Rate Estimation research with the E30 Model can be an answer and will produce data in the form of Geospatial data that can be a reference for watershed management information systems,  The research method uses the E30 Model which only requires three parameters, namely NDVI data obtained from Sentinel 2-MSI Imagery, slope data obtained from DEM data and sample data of the miminum erosion rate and maximum erosion rate in the Maluka watershed at a slope of 30 degrees taken during one year, from field sample data shows a minimum erosion rate of 29.23 mm/year and a maximum erosion rate of 83.67 mm/year, analysis of erosion rate estimation with the E30 model in the Maluka watershed shows the highest erosion rate in the Maluka watershed 1. 000- 1,299.72 tonnes/ha/year covering 128 hectare, 0.15% of the Maluka watershed area.  The smallest erosion rate in the Maluka watershed is 0-15 tonnes/ha/year covering 8,180 hectare, 9% of the Maluka watershed area.  Very severe Erosion Hazard Level (IV-SB) is located in the upper area of the Maluka watershed which is dominated by steep slopes, especially in the Banyu irang sub-watershed which does have a higher slope level than the Bati-bati sub-watershed.  The erosion rate of 180-480, which indicates Severe Erosion Hazard Level (III-B), is spread over more gentle areas, while Moderate Erosion Hazard Level (III-S) dominates in the middle and lower reaches of the Maluka watershed.
EVALUASI PELAKSANAAN REVEGETASI PADA LAHAN PASCATAMBANG BATUBARA (STUDI KASUS DI PT. X DI KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN)
Authors: Fathurrahman Fathurrahman , Kissinger Kissinger , Achmad Basir , Abidin Zainal
Published: December 2023

Coal mining company in PT. X, in Tanah Bumbu District, South Kalimantan Province, uses the open-pit mining method, causing the initial vegetation loss of an area. PT. X has rehabilitated areas affected by mining by reclamation and revegetation to comply with government regulations. The types of vegetation that grew in the post-mining land revegetation area in the planting years 2012, 2014 and 2016 were acacia (Acacia mangium WILLD), trambesi (Samanea saman), sea sengon (Paraserianthes falcataria), and woody and fruit plants such as mahogany (Swietenia macrophylla), agarwood (Aquilaria moluccensis), meranti (Shorea Spp.), sungkai (Peronema canescens), rubber (Hevea brasiliensis), durian (Durio zibethinus), jackfruit (Artocarpus heterophylla), cashew (Anacardium occidentale), mango (Mengifera indica) and galam (Melaleuca cajuputi). Land characteristics have a steep slope of 35° in 2012 and range from 5°-20° in 2014 and 2016 The drainage system for planting years 2012, 2014 and 2016 looks good no erosion strains, planting years 2014 sites are flooded. The results of soil analysis are pH 4.48 - 4.97; the value of C-organic compounds 0.20% (very low) - 1.33% (medium); P2O5 1.89 mg/100g-1 (very low) - 40.10 mg/100g-1 (high);  K2O with values of 8.57 mg/100g-1 (low) - 15.50 mg/100g-1 (medium), 0.20 me/100g-1 (very low) – 19.59 me/100g-1 (low); Mg-exchange at a value of 0.10 me/100g-1 (very low) - 0.20 me/100g-1 (low); Na-exchange of 0.05 me/100g-1 - 0.10 me/100g-1 is low; K-exchange with a value of 0.03 me/100g-1 - 0.05 me/100g-1 is very low, CEC 27.85 me/100g-1 - 52.48 me/100g-1 is low, saturation 0.95% (very low) - 41.56 (high). Based on the success rate of reclamation with revegetation parameters according to the Regulation of the Minister of Forestry No.P.60/Menhut-II/2009, it can be concluded that the success of revegetation obtained for the overall value with an overall value of 24 out of the target value of 50 with a percentage of plant growth of 27%, then the success value of revegetation is categorized as low.
ANALISIS KARAKTERISTIK SPASIAL DAN TEMPORAL HOTSPOT DI TAMAN NASIONAL SEBANGAU PROVINSI KALIMANTAN TENGAH
Authors: Qadri Muhammad Shaa Imul , Rusmayadi Gusti , Priatmadi Bambang Joko , Adriani Dewi Erika
Published: December 2023

Sebangau National Park, in Central Kalimantan Province, is a wetland conservation area. In 2015, forest and land fires resulted in 455 hectares being burned. The identification of hotspots in this study is based on the number and distribution of hotspots based on satellite imagery data from the Moderate Resolution Imaging Spectroradiometer (MODIS) in 2001–2020. This study identifies hotspots by looking at the influence of rainfall and ENSO (El Nino Southern Oscillation) conditions. The method used is the method of spatial and temporal analysis. The aim of this study was to determine the characteristics of the hotspot distribution pattern in Sebangau National Park, Central Kalimantan Province, both spatially and temporally. There is a similarity between the temporal and spatial characteristics of hotspots in the number of significant additions to the number of hotspots in August, September, and October. The influence of monsoonal rainfall types and climates such as ENSO (El Nino Southern Oscillation) greatly influences the occurrence of hotspot events in Sebangau National Park, Central Kalimantan Province. The distribution pattern of hotspots in Sebangau National Park, Central Kalimantan Province, peaked in October, and the worst addition to the number of hotspots occurred in 2015, when these conditions occurred during the dry season and when the ENSO index (El Nino Southern Oscillation) showed +2.6, where these conditions included strong El Nino categories.
OPTIMASI PROSES PENETRALAN AIR ASAM TAMBANG PADA SETTLING POND PT DARMA HENWA TBK JOBSITE PT ARUTMIN INDONESIA SITE ASAM-ASAM
Authors: Maulana Tri Okta , Mirwan Agus , Heryani Hesty , Mizwar Andy
Published: December 2023

One of method which ussualy used in neutralizing Acid Mine Drainage using neutralizing agents is Settling Pond. This treatment process requires adding neutralizing agents to the waters or through a mixing system and allowing deposits to form in the pond. Many factors and process mechanisms can affect the effluent quality of an Acid Mine Drainage processing system. The purpose of this study is to evaluate the effectiveness and optimize the Acid Mine Drainage neutralization process carried out in Settling Pond 19. The research method used is to make theoretical simulations both modeling using PHREEQC and calculations to simulate various neutralization process options. The results showed that the neutralization process was affected by the quality of the neutralizing agent, the number of doses, the saturation index (precipitation) limit, the dissolution process of the neutralizing agent, the duration of dosing, and the duration of neutralization. According to modeling and theoretical calculations, the technical recommendations for optimizing the Acid Mine Drainage neutralization process to produce effluent quality that meets wastewater quality standards are the duration interval to inject neutralizer from every 60 minutes to every 13.6 minutes with a continuous dosing mechanism; The use of a maximum dose of limestone of 0.22 g/L to avoid oversaturated events, and the use of a limestone dissolution mechanism before the injection process is carried out to reduce the need for retention time for 216 seconds.
STATUS MUTU AIR DAERAH ALIRAN SUNGAI DI KABUPATEN BERAU PROVINSI KALIMANTAN TIMUR
Authors: Rizal Muhammad Syamsur , Sofia Leila Ariyani , Asmawi Suhaili , Suyanto Suyanto
Published: December 2023

The watershed in Berau Regency is used as an economic route and means of transportation of goods from mining, plantations, and agriculture as well as a source of raw materials for making drinking water. the water quality of the Berau watershed based on the value of the River Water Pollution Index in Berau Regency includes light pollution. This is a concern to conduct research in the Berau watershed, where this study aims to analyze the status of water quality according to the IP (Pollution Index) method and the economic value of watersheds in Berau Regency for the people of Berau Regency and compile recommendations for pollution control and watershed utilization in Berau Regency.The calculation uses the Pollution Index (IP) method of watershed quality status in Berau Regency consisting of Segah River, Kelay River, and Sungi Berau is in Light Pollution condition with a value of (1.75 ≤ IP ≤ 4.97) with a tendency for Berau River to have a greater pollution burden.
SIFAT AIR LINDIAN DAN TANAH SERTA RESPON TANAMAN PADA MODIFIKASI TEKSTUR, TEHNIK PENGAIRAN DAN APLIKASI LIMBAH PERIKANAN PADA TANAH LAHAN BASAH GARAMAN DARI DESA PANTAI HARAPAN TANAH LAUT KALIMANTAN SELATAN UNTUK PRODUKSI BAWANG MERAH DAN SAWI SISTEM POT
Authors: Fachruzi Ismed , Tony Frans
Published: December 2023

The nature of the soil is massive and saline, not fertile for horticultural crops such as shallots and mustard greens. The soil properties of Tidal Wetland Type-A (direct), the soil sample mentioned above, is known from the analysis results to have an EC value of 153.5 ds/m (very high), Na (1 NH4Oac) 1.21 me/ 100 g soil (very high), pH (1: 5 H2O) 6.74 (neutral), C-organic (Walkley-Black) 2.08% (medium), clay soil texture (clay 76%) and massive structure, Such land is very difficult for agricultural plants such as horticulture to grow, because it is difficult for the soil to pass water and salt which poisons plants. The application of sand, irrigation methods, and organic materials can change the properties of the soil and support the growth of shallots and mustard greens.
Consistency Examination of a Systematic Review and Data Analysis Report for a Social Justice Study—A Mixed Research Model
Authors: Zhang Zhidong , Smith David
Published: December 2023

This study aimed to investigate an approach for assessing the quality of doctoral dissertations, specifically focusing on the consistency between essential elements, namely the literature review and quantitative analysis results. To accomplish this, a mixed-methods design was employed.The qualitative data were analyzed using semantic network and thematic analysis techniques, while the quantitative data were processed using SPSS procedures.The study's findings demonstrated that this mixed-methods model effectively facilitates the examination of dissertation quality and consistency among key elements, such as the literature review and data analysis results. By integrating qualitative and quantitative approaches, researchers gain a comprehensive understanding of the dissertation's quality and the alignment between its different components.
Certification for Teachers and Lecturers and Its Implications For Staff Development
Authors: Madya Suwarsih
Published: December 2023

The improvement of quality and relevancy,of education with the societal needs has been one of the big educational issues in Indonesia. It has been one of the considerations for the decision to adopt Education Act No. 20/2003 on National Education System. With its quality being improved, education will fulfill well its function, which is "to develop the capability, character, and civilization of the nation for enhancing its intellectual capability" (Education Act No.20/2003, Article 3).The enhancement of the intellectual life of the nation is in fact one of the four aims of our independence in 1945, as stated in the fourth paragraphs of the Preamble of the 1945 Constitution.The quality and relevancy of our national education will certainly contribute to the achievement of the god of our national education stated in Article 4 of the 2003 Education Act, which is "developing learners potentials so that they become persons-imbued with human values who are faithful and pious to one and only God; who possess morals and noble character; who are healthy, knowledgeable,-competent, creative; independent; and as citizens are democratic and responsible.".Since formal education is the main stream and it process-mostly takes place in classrooms in which teachers and lecturers play their various roles, the quality of teachers and lecturers is the one of the determining  factor in solving the problem of quality and relevancy. Related to this was the promulgation of "Teachers as Professionals" on 2 December 2005 by President Susilo Bambang Yudhoyono. in the same year. Law No."14/2005 on Teachers and Lecturers was declared valid.Certification is related to the needs for ensuring that teachers and lecturers as professionals possess the qualities which can contribute to the success in achieving quality education which is relevant for society needs which change with the developments resulting from the advancements of science and technology. This paper will explore aspects of certification and its implications for-teacher education, especially EFL teacher education, both pre-service and in-service.
A busca pelo sentido em psicologia transpessoal: a espiritualidade como dimensão constitutiva humana
Authors: Cazelli Felipe Ribeiro
Published: December 2023

A Psicologia Transpessoal é uma abordagem em Psicologia que se constrói sobre uma compreensão de ser humano que considera como constitutiva da psique a dimensão da espiritualidade. O objetivo do presente artigo é explicitar os pressupostos dessa visão, com base em uma análise bibliográfica e dialógica das influências que esse paradigma recebe do pensamento de dois de seus precursores: Abraham H. Maslow e Carl G. Jung. Ambos concordam que o ser humano tende à saúde, que pode ser realizada quando o indivíduo se lança à transcendência, que preenche a vida humana de sentido. Assim, a Psicologia Transpessoal se mostra como uma perspectiva que, através da experiência da espiritualidade, auxilia o indivíduo no alcance da autorrealização, possibilitando uma vida realizada e feliz.
O número sete em Apocalipse 4,1-11,19: simbologia e estrutura do texto
Authors: Souza Carolina Bezerra de , Marcio Ferreira de Araujo
Published: December 2023

O Apocalipse é um livro que inspira, causa temores e curiosidade nas pessoas que o leem atualmente. Há resistência à leitura, devido a interpretações de escatologia futurista. Recentemente, a abordagem literária do Apocalipse vem se apresentando cada vez mais relevante, pois visa compreender a natureza e o processo de significação de sua linguagem e gênero. Como gênero literário, o Apocalipse apresenta uma complexa trama narrativa marcada pelo uso de diversas simbologias. A interpretação dos números na Bíblia é um desafio dentro da exegese, com interpretações variando entre o sentido quantitativo literal ou um sentido figurado em leitura simbólica dos números. Buscaremos, neste artigo, levantar uma discussão sobre a compreensão dos números simbólicos no Apocalipse, por meio de uma aproximação exegética dos capítulos 4 ao 11. Enfatizaremos a análise do número simbólico sete e seu papel na composição literária joanina.
Good Life according to Rubem Alves
Authors: Malheiros Isaac
Published: December 2023

This paper will examine Rubem Alves' concept of “good life”, through a literature review. Alves' eudaimonistic ethics can be found in his theology of human hope and, in a sparse way, in his late theopoetic texts. After his disenchantment with the great political utopias, Alves started to develop insights on how to live a good life in a way, at the same time, aware of the pain and, even so, hopeful. This research will consider the different phases of Alves' thinking and how he dialogues with other thinkers on three major themes: the meaning of life, suffering and the virtues necessary to live a meaningful life. This article shows how Alves tries to balance the perception of the transience and harshness of life with the concept that life needs to be lived with pleasure and desire, but without falling into hedonism.
A espiritualidade cristã como caminho para uma vivência dialogal e prática
Authors: Thiago Braga
Published: December 2023

A espiritualidade cristã envolve uma dimensão de perspectiva experiencial pessoal e comunitária com Cristo.  Nessa dissertação propomos que ela deve ser vista como caminho para uma vivência dialogal e prática, o que representa entender tal espiritualidade como necessariamente aberta ao diálogo inter-religioso, como reflexo de um Deus que se fez de todos e para todos. Para tal, partimos primeiramente de algumas conceituações, definições e correlações entre a espiritualidade cristã e a religiosidade; abordando também a percepção bíblica imprescindível para descrever esse “cristão”, como traço dessa espiritualidade que não se porta indiferente principalmente aos mais necessitados, sendo a verdadeira religião declarada por Tiago (1,27) - essa espiritualidade do cuidado, do acolhimento e da busca pelos mais frágeis e desprezados.
Contribuições de pessoas sem religião com crença sobre espiritualidade e religião
Authors: Claudia Danielle de Andrade Ritz
Published: December 2023

Este artigo é parte integrante da pesquisa de doutorado que versou sobre os sem religião com crença. Como aspecto importante na compreensão da identificação pessoal “eu sou sem religião com crença”, objetivamos apresentar os dados referentes ao significado das designações religião e espiritualidade, para esses indivíduos. Para tanto, iniciamos pela apresentação da palavra que melhor se associa ao termo religião para as pessoas sem religião. Posteriormente avançamos para as contribuições acerca do significado da designação religião e da designação espiritualidade, enquanto conceitos dotados de sentido simbólico. A metodologia utilizada foi mista, composta por pesquisas bibliográfica e de campo, por meio de questionário estruturado digital com discentes da graduação e da pós-graduação da PUC Minas. Concluímos, a partir dos dados, que para as pessoas sem religião com crença, religião e espiritualidade não são interdependentes em significado e tampouco são sinônimas. A religião é sobretudo associada com a Instituição, com as formalidades das doutrinas, dos ritos, das tradições religiosas. Por outro lado, a espiritualidade é descrita como preponderantemente do indivíduo, embora possa facultativamente transcorrer ou ser cultivada em uma instituição religiosa.
Geopolitika straha u Hrvatskoj
Authors: Lučev Josip , Zorko Marta
Published: December 2023

Turizam u doba pandemija postaje gotovo nemoguća djelatnost. S jedne strane, pojedinci ne putuju zbog straha, dok s druge strane države koriste mehanizme obrane poput zatvaranja granica i onemogućavanja kretanja. Takvi mehanizmi imaju geografska obilježja i geopolitički utemeljene posljedice pa geografski faktor postaje važan, a geopolitička analiza neizbježna. Zatvaranje granica u pandemiji imalo je dvostruk negativan efekt. Prvi se negativan efekt odnosi na potencijalno kršenje ljudskih prava u vidu ograničavanja prava na kretanje. U razmatranom slučaju, širenje virusa nije zaustavljeno – zaustavljeno je kretanje građana. Drugi negativan efekt odnosi se na potencijalne gubitke u gospodarstvu. U ovom slučaju zatvaranje granica utjecalo je na gospodarstvo na dva načina: prekidanjem transporta i opskrbe te zaustavljanjem turističke djelatnosti. U fokusu ovog istraživanja su mehanizmi obilježavanja prostora sigurnim odnosno nesigurnim i s time povezana geopolitika straha, koji su, uz mehanizme zatvaranja granica, ostavili trag na turizam u Hrvatskoj za vrijeme pandemije COVID-19. Analiza mjera vezanih uz zatvaranje granica te usporedna analiza podataka i noćenja u 2020. i 2021. godini ukazuju na uzorke kretanja za vrijeme pandemije, ali i potencijalne posljedice po turizam uz važnost geografskog faktora. Rad kroz promišljanja o propusnosti granica na primjeru Hrvatske i Slovenije ukazuje na tri isprepletene strategije definiranja pandemijskog prostora – zatvaranje države u obrnutu karantenu, širenje sigurnogprostora i definiranje nesigurnog prostora na koji se primjenjuje klasična karantena.
Ekonomska sigurnost osoba s odobrenom međunarodnom zaštitom u Hrvatskoj
Authors: Selo Šabić Senada , Bužinkić Emina , Butković Hrvoje
Published: December 2023

Ovaj članak analizira položaj osoba s odobrenom međunarodnom zaštitom, s ‎posebnim osvrtom na iskustvo njihova zapošljavanja, odnosno stjecanja ekonomske sigurnosti. Ekonomska sigurnost i neovisnost pretpostavka su i temelj ‎uspješne integracije osoba s odobrenom međunarodnom zaštitom u društvo. ‎Ipak, unatoč mogućnostima predviđenima zakonskim rješenjima, rijetki slučajevi zapošljavanja i nedostatna ekonomska sigurnost osoba s međunarodnom zaštitom među ključnim su problemima u njihovoj integraciji. Ovaj članak donosi pregled relevantne literature u području zapošljavanja izbjeglica, ‎studiju slučaja integracijskog programa jedne nevladine organizacije, preporuke koje se tiču unaprjeđenja politike zapošljavanja izbjeglica te daje doprinos raspravi o donošenju useljeničke politike s naglaskom na socio-ekonomska prava i prilike za kvalitetnu integraciju izbjeglica i migranata‎‎
Demographic Characteristics of Pre-Vaccinated Asymptomatic and Symptomatic SARS-CoV-2 Cases in Barwon South West Victoria, Australia
Authors: Tobin-Salzman Shinae C , Cooper Darcie , McNamara Bridgette J , Athan Eugene , Bennett Catherine M
Published: December 2023

We investigated 328 SARS-CoV-2 cases in Barwon South West Victoria, Australia, in the 2020 pre-vaccination period, comparing infections with symptoms to those that remained asymptomatic. De-identified self-reported data from three sequential questionnaires on case characteristics and symptom progression were examined. Multivariable logistic regression were used to model associations between demographic profile and symptoms. Asymptomatic cases were more than three times as likely to be from ethnic minority groups [OR 3.2, 95% CI 1.5 – 6.7, p<0.01], and approximately seven times more likely to be seniors (≥ 65 years) [OR 7.3, 95% CI 1.0 – 50.1] after adjusting for sex and occupation. The overrepresentation of ethnic minority groups among asymptomatic infections is suggestive of genetic haplotype variability by ethnic group, conferring greater cross protection from other coronaviruses in the early stages of the COVID-19 pandemic. This research should be repeated post-vaccination to reassess symptom expression according to ethnicity, and better comprehend case ascertainment impacts of cultural biases in testing and infection reporting, and the reliance on symptoms to trigger testing. These findings may in part reflect differences in testing patterns by ethnicity and true differences in disease expression, both important for appropriate transmission prevention strategies, and tailoring testing messaging towards ethnic minority communities.
Switching to Vortioxetine in Patients with Poor- Tolerated Antidepressant-Related Sexual Dysfunction in Clinical Practice: A 3-Month Prospective Real-Life Study
Authors: Montejo Angel L. , Sanchez-Sanchez Froilan , De Alarcón Rubén , Matías Juan , Cortés Benjamin , Matos Claudia , Martín-Pinto Tomás , Rios Peñitas , González-García Nerea , Acosta José María
Published: December 2023

Treatment-emergent sexual dysfunction (TESD) is one of the most frequent and persistent adverse effects of antidepressant medication. Sexual dysfunction (SD) secondary to SSRIs occurs in >60% of sexually active patients and >80% of healthy volunteers, with this causing treatment discontinuation in >35% of patients. However, this factor is rarely addressed in routine examinations, and only 15%-30% of these events are spontaneously reported. A strategy of switching to a different non-serotonergic antidepressant could involve a risk of relapse or clinical worsening due to a lack of serotonergic activity. Vortioxetine appears to have less impact on sexual function due to its multimodal mechanism of action. No studies have been published on the effectiveness of switching to vortioxetine in patients with poorly tolerated long-term antidepressant-related SD at naturalistic settings.
Study objectives: To determine the effectiveness of switching to vortioxetine due to SD in a routine clinical practice setting.
Methodology: observational pragmatic and naturalistic study to determinate the effectiveness of the switch to vortioxetine (mean dosage 13.11±4.03) in 74 patients aged 43.1 ± 12.65 ( 54% males) at risk of discontinuing treatment due to sexual dysfunction. The SALSEX Scale was applied at two moments: baseline visit and after 3 months of follow-up.
Results. The global Sexual Dysfunction (SD) measured with the SALSEX Scale, decreased significantly from baseline visit (10.32; SD 2.73) to follow-up visit (3.78; SD 3.68) p<0.001. There was a significant improvement ( p<0.001) at the endpoint including decreased libido, delay of orgasm, anorgasmia and arousal difficulties in both sexes. After switching to Vortioxetine, 83.81% of patients experienced sexual function improvement (43.2% felt greatly improved). Most patients (83.3%) who switched to vortioxetine continued treatment after the follow-up visit. 58.1% of patients showed an improvement in depressive symptoms from baseline visit. Conclusion. Switching to vortioxetine is an effective and reliable strategy to treat patients with poor tolerated previous antidepressant -related sexual dysfunction in the real-life clinical settings.
A Hybrid Method for Calculating the Chemical Composition of Steel with the Required Hardness After Cooling from the Austenitizing Temperature
Authors: Trzaska Jacek , Sitek Wojciech
Published: December 2023

The article presents a hybrid method for calculating the chemical composition of steel with the required hardness after cooling from the austenitizing temperature. Artificial neural networks and genetic algorithms were used to develop the model. Based on 550 diagrams of continuous cooling transformation (CCT) of structural steels available in the literature, a dataset of experimental data was created. Artificial neural networks were used to develop a hardness model describing the relationship between the chemical composition of the steel, the austenitizing temperature, and the hardness of the steel after cooling. A genetic algorithm was used to identify the chemical composition of the steel with the required hardness. The value of the objective function was calculated using the neural network model. The developed method for identifying the chemical composition was implemented in a computer application. Examples of calculations of mass concentrations of steel elements with the required hardness after cooling from the austenitizing temperature are presented. The model proposed in this study can be a valuable tool to support chemical composition design by reducing the number of experiments and minimizing research costs.
Three-Dimensional Cultures for Collecting CNS and PNS Glial Secreted Factors, Vesicles and Scaffolds Free of Animal Serum Components
Authors: Cocola Cinzia , Mohamed Tasnim , Piscitelli Eleonora , Pelucchi Paride , Abeni Edoardo , Mosca Ettore , Petro Guiseppina De , Porta Giovanni , Kehler James , Götte Martin , Zucchi Ileana , Magnaghi Valerio , Reinbold Rolland
Published: December 2023

Glial cells provide physical and chemical support and protection for neurons. Secreted neurotrophic factors, scaffolds and vesicles regulate in addition to normal homeostasis, repair following neural tissue injury or degeneration. We previously demonstrated that human CNS glia have revascularization capacity by inducing endothelial cell sprouting and microchanneling driven by glial cell secreted components. The clinical potential of using secreted factors and vesicles generated by glial cells in conditioned media was shown by their re-normalization of pathological blood vessels and 3D tissue wound healing and remodeling capacity. To identify secreted components of glial cells and how CNS and PNS glial cells differentially regulate neural tissue homeostasis, disease and injury response, we developed a novel culture method for various types of glial cells that allow for isolating and characterizing secreted glial components, free of animal factors and contaminants normally associated with serum-based culture conditions. Our culture method will enable to identify secreted components using ultrasensitive RNA, glycoconjugate and protein analysis technologies. The characterization of glial secreted factors involved microchanneling may help in development of new clinical therapies for glial and neural cells or axons to migrate and reform connections.
Efficient Indexing of Meta-Data (Extracted From Educational Videos)
Authors: Kumbham Shalika , Debnath Abhijit
Published: December 2023

Video lectures are becoming more popular and in demand as online classroom teaching is becoming more prevalent. Massive Open Online Courses (MOOCs), such as NPTEL, have been creating high-quality educational content that is freely accessible to students online. A large number of colleges across the country are now using NPTEL videos in their classrooms. So more video lectures are being recorded, maintained, and uploaded. These videos generally contain information about that video before the lecture begins. We generally observe that these educational videos have metadata containing five to six attributes: Institute Name, Publisher Name, Department Name, Professor Name, Subject Name, and Topic Name. It would be easy to maintain these videos if we could organize them according to their categories. The indexing of these videos based on this information is beneficial for students all around the world to efficiently utilise these videos. In this project, we are trying to get the metadata information mentioned above from the video lectures.
Fast Synthesis of Fine Boron Carbide Powders using Electromagnetic Induction Synthesis Method
Authors: Gubarevich Anna V. , Yoshida Katsumi
Published: December 2023

Boron carbide (B4C) powders with defined stoichiometry, high crystallinity, minimal impurity content, and a fine particle size are imperative for realizing the exceptional properties of this compound in advanced high-technology applications. Nevertheless, achieving the desired stoi-chiometry and particle size using traditional synthesis methods, which rely on prolonged, high-temperature processes, can be challenging. The primary objective of this study is to syn-thesize fine B4C powders characterized by high crystallinity and a sub-micron particle size, em-ploying a fast, and energy-efficient method. B4C powders are synthesized from elemental boron and carbon in a high-frequency induction heating furnace using the Electromagnetic Induction Synthesis (EMIS) method. The rapid heating rate achieved through contactless heating promotes the ignition and propagation of the exothermic chemical reaction between boron and carbon. Additionally, electromagnetic effects accelerate atomic diffusion, allowing the reaction to be completed in an exceptionally short timeframe. The grain size and crystallinity of B4C can be finely tuned by adjusting various process parameters, including the post-ignition holding temperature and the duration of heating. As a result, fine B4C powders can be synthesized in under 10 minutes. Moreover, these synthesized B4C powders exhibit high resistance to oxidation when exposed to air.
Validation of a Severe Acute Respiratory Syndrome Coronavirus 2 Microneutralization Assay for Evaluation of Vaccine Immunogenicity
Authors: Hamilton Stephanie , Zhu Mingzhu , Clark Shane Cloney , Mayes Penny , Fenner Jen , Cui Leah , Cai Rongman , Kalkeri Raj , Fries Louis F , Pryor Melinda , Plested Joyce
Published: December 2023

As variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge, assessment of vaccine immunogenicity remains a critical factor to support continued vaccination. To this end, an in vitro microneutralization (MN50) assay was validated to quantitate SARS-CoV-2 neutralizing antibodies against ancestral and variant strains (Beta, Delta, Omicron BA.1, Omicron BA.5 and XBB.1.5) in human serum. For ancestral strain, the MN50 assay met acceptance criteria for inter-/intra-assay precision, specificity, linearity, and selectivity. The assay was robust against changes to virus/serum incubation time, cell seeding density, virus content per well, cell passage number, and serum interference. Analyte in serum samples was stable up to 5 freeze/thaw cycles and for up to 12 months of storage at –80 ± 10 °C. Similar results were observed for the variant-adapted MN50 assays. The conversion factor to convert assay result units to WHO international standard units (IU/mL) was determined to be 0.62 for the ancestral prototype strain. This MN50 assay will be useful for vaccine immunogenicity analyses in clinical trial samples, enabling assessment of vaccine immunogenicity for ancestral and variant strains as variant-adapted vaccines are developed.
A Real-time Comparative Study of Sliding Mode and State Feedback Control for the Centrifugal Motor Pump in an Ultraviolet Water Treatment System Using the Bond Graph Approach
Authors: Riahi Said , Zitouni Naoufel , Abidi Hsen , Mami Abdelkader
Published: December 2023

The purpose of water treatment through ultraviolet (UV) radiation is to interrupt the development and multiplication of microorganisms by preventing their growth and reproduction.Ultraviolet treatment has become a very affordable solution to produce clean water of optimal quality in regions where access to drinking water is essential. The experimental water treatment unit is powered by a photovoltaic (PV) source. It incorporates a discharge lamp used to generate ultraviolet radiation, which is harnessed to address bacteriological issues related to water quality. This lamp is continuously powered by a photovoltaic (PV) source through an inverter and an electronic ballast. The water treatment system also includes a motor pump designed to draw contaminated water from the input reservoir, a flow control valve to adjust flow rates as needed, and a filter aimed at enhancing the quality of the contaminated water. The water circulates between the input reservoir (contaminated water) and the output reservoir (treated water) through the UV lamp. The relationship between the intensity of the UV lamp and the water flow rate can ensure an adequate water quality.
Unraveling the Tapestry: Immune Imprinting Amidst a Spectrum of Challenges for modRNA COVID-19 Vaccines
Authors: palacios castrillo Ronald
Published: December 2023

Among the number of hurdles that the vaccines based in modRNA platforms have been facing, there is now another critical one: immune imprinting which decreases even more the effectiveness of the modRNA Covid vaccines.
Tangles with k Ropes and 2k Hands
Authors: Hari Aashna , Li Emma , Liu Rachel
Published: December 2023

This paper will explore analogs of groups formed by the transformations of two ropes as presented by Minh-Tam Quang Trinh.1 The two operations acting on these ropes are T and S, defined as twists and clockwise turns, respectively. These actions intertwine the ropes, creating tangles. T and S also have the ability to untangle the rope when used in certain combinations. In the two-rope case, these actions expressed as a group presentation were shown to be isomorphic to SL2(Z). We explored the analog of these opera- tions, T and S, and conjectured the corresponding group to which they are isomorphic. Partial proofs for this conjecture are included and future work would include proving our conjecture as well as generalizing results to k ropes.
Project-based Digital Science Module (DSM) An Analysis of Students' Self-regulated learning and Scientific Writing Ability
Authors: Mukhid Abd. , Harianto Rony , Rufii Rufii
Published: December 2023

Learning today continues to lead to digitalization, including in higher education. The demands of students as academics must be able to produce scientific work independently, for this reason, the purpose of this study is to analyze the self-regulated learning and the ability to write scientific papers of students after learning with the Project-Based Digital Science Module (DSM). This research is a mixed methods by analyzing quantitatively and qualitatively. The research instrument used to obtain data is using a product assessment sheet and a self-regulated learning questionnaire. Data analysis uses N-Gain to determine the increase in self-regulated learning scores and student scientific writing skills scores, and uses linear regression analysis to determine the effect of self-regulated learning on student scientific writing skills. In addition, based on the results of data analysis, it can be seen that there is an influence of self-regulated learning on the ability to write scientific papers of students after learning using the Project-Based Digital Science Module (DSM).
Achievement of Food Waste Recycling Law in Japan With Reference to SDG12.3
Authors: Okayama Tomoko , Watanabe Kohei
Published: December 2023

SDG target 12.3 calls for halving food waste at retail, food service, and household by 2030. The food waste index for this purpose includes parts attached to food that are usually removed intentionally ("unavoidable food waste") and allows counting the conversion to animal feed and utilisation as biomaterial as means of reduction. In Japan, the "Food Waste Recycling Law" which has been in effect since 2001, promotes the recycling of food waste generated from businesses, designating feed conversion as top priority. On the other hand, based on the more recent "Food Loss Reduction Promotion Act" of 2019, the government is currently promoting the reduction of avoidable food waste, as to meet the SDG target. Based on statistical sources and interviews with Ministry officers, this paper explains the history and achievements of Japan's 23-year policy based on the Food Recycling Law, as well as the tension between the two legislations.
Cardiometabolic Morbidity (Hypertension and Obesity) in PTSD: Treatment Implications for the Predictive Validity of Two Structures of the Impact of Event Scale-Revised
Authors: Ali Amira Mohammed , Al-Dossary Saeed A. , Laranjeira Carlos , Atout Maha , Khatatbeh Haitham , Selim Abeer , Alkhamees Abdulmajeed A. , Aljaberi Musheer A. , Pakai Annamária , Al-Dwaikat Tariq
Published: December 2023

Posttraumatic stress disorder (PTSD) and/or specific PTSD symptoms may evoke disordered eating and unhealthy lifestyles, resulting in adverse cardiometabolic events (e.g., hypertension and obesity) in certain groups, which may implicate the treatment of this complex condition. The diagnostic criteria of PTSD have lately expanded beyond the three common symptoms (intrusion, avoidance, and hyperarousal). Simultaneously, four-, five-, and six-dimensional structures of the Impact of Event Scale-Revised (IES-R), a popular PTSD measure, seem to be more robust than the original three-dimension structure. Within the context of COVID-19, this instrumental study used a convenience sample of 58 dental healthcare workers (HCWs) from Russia (mean age = 44.1±12.2 years, 82.8% females) to examine the criterion and predictive validity of two IES-R structures: the IES-R3 and the IES-R6 (with the added symptoms of numbing, sleep disturbance, and irritability). The subscales of the two IES-R structures expressed good internal consistency, strong correlations with the PTSD Symptom Scale (PSS), hypertension diagnosis, and high body mass index (BMI). In receiver-operating characteristic (ROC) curve analysis, all IES-R models perfectly predicted the PSS (all area under the curve (AUC) >0.9, p values <0.001). The IES-R, both hyperarousal subscales, and the IES-R3 intrusion subscale significantly predicted high BMI. Both avoidance subscales and the IES-R3 intrusion subscale, not the IES-R, significantly predicted hypertension. In conclusion, both IES-R structures can reliably measure PTSD symptoms. The IES-R, hyperarousal, and intrusion may be credible criterion variables for predicting high BMI within PTSD while the intrusion and avoidance subscales may reflect the cardiovascular consequences associated with PTSD more reliably than the IES-R itself. The IES-R subscales may predict cardiometabolic adversities in PTSD, signifying a need for proper assessment of lifestyle and the application of dietary and exercise interventions in order to lower physical morbidity in PTSD. Replicating the study in larger samples, which comprise different physical and mental conditions from heterogenous cultural contexts is pivotal to validate the results (e.g., in specific groups such as those with confirmed traumatic exposure and comorbid mood dysfunction).
Survey of Veterinarians’ Experiences and Perceptions of the Diagnosis of Spironucleosis in Game Birds
Authors: Hylands Matthew , Hands Natasha , Clark Michael , Elsheikha Hany
Published: December 2023

Spironucleosis is considered one of the most significant enteric infectious diseases in young and growing game birds. Despite its importance diagnosing spironucleosis in game birds remains a continuing problem as no 'gold standard' test exists and there is no consensus for the use of the available methods for the diagnosis of spironucleosis in game birds. In this study we describe veterinarians’ perceptions of the adoption of existing methods for the diagnosis of spironucleosis in game birds and identify implications for the development of diagnostic guidelines. A questionnaire was used to evaluate participants’ familiarity with and use of existing diagnostic methods for spironucleosis, and to assess their perceptions of the adoption of these methods in their geographic regions. We surveyed veterinarians in practices in East Anglia (EA) and Northern Ireland (NI), UK with expertise or involvement in the treatment and/or diagnosis of spironucleosis in game birds. Of the 261 participants surveyed, 15 EA and 13 NI veterinarians (10.7%) responded to the questions on existing diagnostic methods. The study results indicate an overall insufficient knowledge and skills in the diagnosis and treatment of spironucleosis among veterinarians surveyed. These findings highlight the need for improved training of veterinarians in the diagnosis of spironucleosis.