bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis
Authors: Gu Jia , Qin Gang , Jiang Liang , Xu Wei , Wang Yuanyuan , Liao Jiangxue , Pan Hongzhu , Liang Zhuoping
Published: February 2023

Background
As a newly described member of interleukin (IL)-1 superfamily, IL-36 has become a hot spot and frontier in inflammation and immunity research. However, whether IL-36 is correlated with the subjective and objective assessment results of allergic rhinitis (AR) and then affects the severity of AR remains unknown. So, this study aimed to investigate the correlations between their concentration levels and subjective and objective assessment results, and to further analyze their possible mechanisms in the development of AR.
Methods
An enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration levels of the IL-36 family cytokines IL36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 in the peripheral blood of patients with AR. The condition of patients with AR was assessed by 22-item sino-nasal outcome test (SNOT-22) score, visual analogue scale (VAS) scores for disease severity, and serum inhalant allergen immunoglobulin E (IgE) detection. Correlations between IL-36 family cytokines and subjective and objective assessment results in patients with AR were analyzed.
Results
The concentration level of IL-36α in the peripheral blood of patients with AR was the highest, and the concentration level of IL-36β was the lowest. The concentration level of IL-36α was higher in juvenile patients than in adult patients, and there was a difference in IL-36Ra level between the perennial allergen group and the seasonal allergen group. There was a positive correlation between IL-36α level and IL-36γ, IL-36γ level and IL-36Ra, IL-36Ra level and IL-38, and IL-36β level was positively correlated with IL-36Ra and IL-38. IL-36α level was positively correlated with VAS score for nasal congestion symptom, and IL-36β level was positively correlated with VAS scores for ocular itching and eye pain symptoms. However, there was no correlation between the concentration levels of all cytokines in the IL-36 family and SNOT-22 score, total VAS score for severity of illness, the number of positive inhalant allergens, or the highest positive intensity of allergen specific IgE (sIgE).
Conclusion
Peripheral blood IL-36 family cytokines play an important role in the disease of AR, and the concentration levels of IL-36α and IL-36β were related to the severity of symptoms in patients with AR.
Modulatory influence of exercise training against Cisplatin inveigled inflammatory markers and dyslipidemia in rats
Authors: Parastesh Mohammad , Aria Behzad , Abbasi Yusef , Yousefvand Zahra
Published: February 2023

Background and objective: Cisplatin treats some cancers, but its side effects have questioned its use. It seems that exercise activity can reduce its side effects. The present study aimed to investigate the impact of two types of exercise training on some inflammatory markers and dyslipidemia induced by Cisplatin in rats.
Methods: 24 Sprague Dawley rats were divided into four groups: Healthy control (HC), Cisplatin control (CC), Cisplatin moderate-intensity continuous training (C-MICT), and Cisplatin high-intensity interval training (C-HIIT). Intraperitoneal injection induced irradiation at a 5‏mg/kg dose dissolved in normal saline. The exercise training lasted ten weeks.
Results: Cisplatin significantly increased Interleukin-6 (IL-6; p<0.05) and tumor necrosis factor-alpha (TNF-α; p<0.05) in the cisplatin control group. However, there was no difference between IL-6 in the HC, C-MICT, and C-HIIT groups. The TNF-α in the two training groups was higher than the healthy control group (p<0.05) but lower than the Cisplatin control group (p<0.05). Also, the two training groups observed no significant difference between serum levels of IL-6 and TNF-α (p>0.05). Total cholesterol (TC), Triglycerides (TG), and Low-density lipoprotein cholesterol (LDL-C) were significantly higher in CC than in other groups (p<0.05) but High-density lipoprotein cholesterol (HDL-C) was lower(p<0.05). Both types of exercise training caused a significant decrease in LDL, TC, and TG(p<0.05), and a significant increase in HDL-C (p>0.05). Finally, there was no difference between the two types of exercise training on lipoproteins(p>0.05).
Conclusion: It seems that MICT and HIIT can reduce inflammatory responses and improve blood lipids profile in rats induced by Cisplatin.
Evolutionary Algorithm for Optimized CNN Architecture Search Applied to Real-Time Boat Detection in Aerial Images
Authors: Zerrouk Ilham , Moumen Younes , Khiati Wassim , Habchi Ali El , Berrich Jamal , Bouchentouf Toumi
Published: February 2023

When processing the detection of boats on aerial images by neural networks, we have always been concerned about the execution time of these networks in the equipment on board the Unmanned AerialVehicle (UAV). The UAV, throughout its mission, will capture images that must be processed in realtime. For this, an execution time optimized network is essential. This article proposes a method for searching for optimized detection networks, for a given dataset, using an evolutionary algorithm. The search uses mutations as a mechanism of evolution that affect the structure of the network and the hyper-parameters of its layers. Its fitness function allows the choice of architectures that are not very greedy in terms of operations favoring small networks whose advantages are to be fast and quick to train and thus to accelerate the search algorithm. Thanks to this method we were able to obtain detection networks with performance similar to the initial network (parent) but with much fewer operations allowing considerable gains in terms of execution times in an environment embedded on a drone.
The role of structural distortions in triggering the metal to insulator transition in NdNiO3
Authors: Gomes Mariana , Balagopalan Manjunath , Vilarinho Rui , Bassou Abderrazzak Ait , Silva Bruna , Oliveira João , Almeida Bernardo , Almeida Abílio , Kreisel Jens , Tavares Pedro , Íñiguez Jorge , Moreira Joaquim
Published: February 2023

The role of the structural distortions on the metal to insulator transition (MIT) of NdNiO3 is still a controversial topic. NdNiO3 ceramic, 260 nm and 110 nm thin films deposited onto (001)-oriented LaAlO3 substrates were studied to unravel the effect of structural symmetry breaking on the electronic phase transition. Resistivity measurements evidence the coexistence of metallic and insulating states below the TMI, while magnetization measurements confirm the expected TMI = TN for all samples. The structural symmetry was investigated across the MIT, through Raman scattering spectroscopy, with the orthorhombic Pnma phase being found at high temperatures, but the emergence of the monoclinic P21/n phase only occurring well below TMI, which is an unexpected experimental result since the structural transition has been understood as a necessary trigger for the MIT. These experimental results, which are noticeably independent of the sample type/quality, imply a temperature difference between the structural and electronic/magnetic ordering, thus contrasting with current theoretical models.
Analyses of natural okra extracts as corrosion inhibitors on mild steel in acidic medium
Authors: Sulaimon Aliyu Adebayo , Murungi Pearl Isabellah , Tackie-Otoo Bennet Nii , Nwankwo Princess Christiana , Bustam Mohamad Azmi
Published: February 2023

Plant extracts have been shown to effectively inhibit the corrosion of metals. Using the Box-Behnken, gravimetric, and electrochemical techniques, analyses were designed to investigate the anti-corrosion potential of okra in a 1M HCl medium. The inhibition performances derived from the various methods were in good agreement, demonstrating that physio-chemisorption was effective and adhered to the Langmuir isotherm. The efficiency of okra mucilage powder was 96% at a much lower concentration, compared to 91.2% and 88.4% for the unsieved extract and gelly-okra filtrate, respectively. FTIR results showed the presence of several functional groups that promoted adsorption, and TGA analysis revealed that the extract had high thermal stability. The FESEM analysis also revealed evidence of adsorption. It was determined that corrosion inhibition by okra mucilage extract was primarily influenced by temperature, followed by extract concentration, with immersion time having the least effect. From the model optimization goal, 200ppm, 60°C, and 24h for 89.98% IE gave a high desirability. The results showed the high capacity of okra as an efficient biodegradable corrosion inhibitor.
Mediterranean Diet and Associations with the Gut Microbiota and Pediatric-Onset Multiple Sclerosis: a Trivariate Analysis
Authors: Mirza Ali , Zhu Feng , Knox Natalie , Black Lucinda , Daly Alison , Bonner Christine , Domselaar Gary Van , Bernstein Charles , Marrie Ruth Ann , Hart Janace , Yeh Eluen Ann , Bar-Or Amit , O’Mahony Julia , Zhao Yinshan , Hsiao William , Banwell Brenda , Waubant Emmanuelle , Tremlett Helen
Published: February 2023

The interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We conducted a case-control study to assess an interrelationship between diet, the gut microbiota, and MS by including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food-frequency questionnaire ≤ 21-years of age, and 59 also provided a stool sample. A 1-point increase in a Mediterranean diet score was associated with 37% reduced MS odds (95%CI: 10–53%). Higher fiber and iron intakes were also associated with reduced MS odds. Diet, not MS, explained inter-individual gut microbiota variation. Several gut microbes abundances were associated with both the Mediterranean diet score and MS presence, and these microbes were potential mediators of the protective associations of a healthier diet. Findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.
Perceived stigma of COVID-19 patients in Shanghai, China, in the third year of the pandemic: A cross-sectional social impact survey
Authors: Deng Ziru , Bernot Ausma , Davies Sara E.
Published: February 2023

Introduction
Social stigma associated with Covid-19 infection has been reported around the world. This paper investigates the level of self-reported perceived stigma among people infected with COVID-19 in Shanghai, China, in the third year of the pandemic to determine changes in perceived stigma and individual level variables associated with perceived stigma.
Methods
We conducted a self-reported two-part online survey (n = 144 responses) by employing a convenience sampling method of COVID-19 patients in Shanghai. The first part of the survey collects sociodemographic information of the respondents and the second part outlines 24 items of the Social Impact Scale (SIS), which measures social rejection, financial insecurity, internalized shame, social isolation. We ran Wilcoxon signed-ranks test, Kruskal-Wallis test, and linear regression analysis to assess the levels of perceived stigma differences.
Results
The study finds that the overall level of self-reported stigma during the COVID-19 lockdowns in Shanghai in 2022 was moderate, and lower than that compared to the self-reported perceived stigma study in Wuhan in 2020. In Shanghai, the severity of the disease and hospitalization times had most impact on financial insecurity and feelings of social isolation. These experiences were not gendered. Recovery measures, including economic considerations, need to pay particular attention to those who experienced severe disease.
Dual inhibition of thioredoxin 1/ glutathione induces ferroptosis in chronic myeloid leukemia cells
Authors: Cao Peng , Sun Xiaoyan , Zhang Chunli , Fan Bo , Liu Qingyu , Wang Shuxia , Chen Ting , Cai Xueting , Wang Xiaoqing , Hu Chunping , Sun Han-Dong , Wen Zhongpei , Puno Pematenzin
Published: February 2023

Ferroptosis is an iron-dependent cell death induced by the oxidation of polyunsaturated fatty acids. In recent years, ferroptosis has garnered tremendous potential in cancer therapy. However, the significance pathways of ferroptosis in chronic myeloid leukemia (CML) therapy are still poorly understood. Here, we investigated the role of a critical antioxidant protein, thioredoxin 1 (Trx1), in regulating ferroptosis in CML cells. First, we showed that Trx1 expression was higher in patients with CML than in healthy controls. Specifically, Trx1 knockdown suppressed cell growth and slowed tumor progression in xenograft models. Pharmacological inhibitors of Trx1 also attenuated cell growth, reduced colony formation, and caused CML cell death. Second, we showed that decreased Trx1 expression enhanced the cytotoxicity of the glutathione (GSH) biosynthesis inhibitor buthionine sulfoximine. Mechanistically, the combined inhibition of Trx1 and GSH synthesis disrupted the homeostasis of cellular reactive oxygen species as evidenced by increased ROS and malondialdehyde; and decreased GSH. Importantly, inhibition of Trx1 significantly resentisized GSH-depletion induced ferroptosis in CML cells. Finally, targeting Trx1 and GSH synthesis with small-molecule inhibitors caused a synergic effect on CML cells both in vitro and in vivo.Together, these results highlight an critical role of Trx1 in GSH-depletion induced ferroptosis and provide clues for dual inhibition of the Trx1 and GSH system as a combinatorial strategy for CML therapy.
Cellular Schwannoma of the Kidney: a case report and review of the literature
Authors: Liu Jiong , An Xiaojing , Yang Bin , Zhang Wei , Dong Xiaoxia
Published: February 2023

Background: Cellular schwannomas (CS) are uncommon tumors derived the schwan cell of peripheral nerve,which are rare in the kidneys, and only individual cases have been reported. Because there are no typical clinical symptoms and imaging features, CS is usually misdiagnosed as synovial sarcoma or malignant peripheral nerve sheath tumor (MPNST) resulting in overtreatment.
Case presentation: A 68-year-old woman presented to hospital without clinical symptoms, who was incidentally found to have an renal-occupying lesion during physical examination. Abdominal computed tomography and magnetic resonance imaging revealed a solid lesion in the middle of the left kidney. The lesion was 5.7 × 3.6cm2.
Conclusions: CS was diagnosed depend on the combination of pathomorphology, immunohistochemistry and molecular. The patient underwwent surgery. Follow-up data were available and no recurrence or metastasis found.
Neural encoding with unsupervised spiking convolutional neural network
Authors: Wang Chong , Yan Hongmei , Huang Wei , Sheng Wei , Wang Yuting , Fan Yun-Shuang , Liu Tao , Zou Ting , Li Rong , Chen Huafu
Published: February 2023

Accurately predicting the brain responses to various stimuli is big challenge in neuroscience. Although recent fMRI studies have made significant breakthroughs in neural encoding using convolutional neural networks (CNNs), there remains critical gaps between the computational rules of traditional artificial neurons and real biological neurons. Here, we present a spiking CNN (SCNN)-based framework to accomplish neural encoding in a more biologically plausible way. The framework extracts visual features of the image stimuli using the unsupervised SCNN and predicts fMRI responses from the SCNN features using a receptive field-based regression algorithm. Experimental results on both handwritten characters and natural images demonstrate that our approach can achieve surprisingly good encoding performance and be used for realizing “brain reading” tasks such as image reconstruction and image identification. Our work suggests that SNN can serve as a promising tool for neural encoding.
Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder
Authors: Lu Yi , Xiong Ying , Karlsson Robert , Song Jie , Kowalec Kaarina , Rück Christian , Sigstrom Robert , Jonsson Lina , Clements Caitlin , Andersson Evelyn , Boberg Julia , Lewis Cathryn , Sullivan Patrick , Landén Mikael
Published: February 2023

Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed to derive a stringent definition of treatment resistance and to investigate genetic overlap between treatment response and resistance in MDD. Using electronic medical records on the use of antidepressants and electroconvulsive therapy (ECT) from Swedish registers, we derived the phenotype of treatment-resistant depression (TRD) within ~ 4 500 individuals with MDD in three Swedish cohorts. Considering antidepressants and lithium are first-line treatment and augmentation used for MDD, respectively, we generated polygenic risk scores of antidepressant and lithium response for individuals with MDD, and evaluated their associations with treatment resistance by comparing TRD with non-TRD. Among 1 778 ECT-treated MDD cases, nearly all (94%) used antidepressants before first ECT, and the vast majority had at least one (84%) or two (61%) antidepressants of adequate duration, suggesting these MDD cases receiving ECT were resistant to antidepressants. We found that TRD cases tend to have lower genetic load of antidepressant response than non-TRD, although the difference was not significant; furthermore, TRD cases had significantly higher genetic load of lithium response (OR = 1.10–1.12 under different definitions). The results support evidence of heritable components in treatment-related phenotypes and highlight the overall genetic profile of lithium-sensitivity in TRD. This finding further provides a genetic explanation for lithium efficacy in treating TRD.
Using Free Online Readings to Teach Introduction to American Government
Authors: Kaufman Chelsea
Published: February 2023

Several studies have examined using electronic textbooks as compared to print textbooks, or open educational resources (OER) compared to commercial textbooks. Fewer studies, however, examine the use of free or low-cost online readings that are not an OER textbook or assigned in conjunction with a textbook. In my introductory American Government course, all assigned course readings were items that students could access for free online or through the university library. The use of these free or low-cost materials should have provided similar benefits to students as the adoption of an OER textbook typically would, namely cost savings. At the same time, they could have drawbacks similar to OERs and electronic textbooks, such as students having difficulty finding information within the text or accessing materials if they do not have home Internet access. Furthermore, this approach required more preparatory work for the instructor. Based on a survey of my students in the course, I found that students had positive evaluations of the course materials and recommended that they be used in future courses. As expected, their overall assessments were similar to those of electronic textbooks and OERs.
Food Insecurity and Dental Caries in Rural Mexican Populations
Authors: Romo-Sáenz César Iván , Chavez-Reyes Erika Marlene , Gomez-Flores Ricardo , González-Flores María Norma , Sosa-Martínez Ricardo , Cruz-Fierro Norma , Elizondo-Elizondo Jose , Garza-Ramos Myriam Angelica
Published: February 2023

Objectives
Food insecurity (FI) is a priority for government and health organizations. Over 95% of the world's population has a carious lesion or will develop one before death. This study evaluated the association between FI and oral health in two rural communities in Chiapas, Mexico.
Materials and methods
The study was conducted with patients attending an oral health campaign for dental check-ups. Data were collected between April and August of 2017 using the Latin-American and Caribbean Scale of Food Security (ELCSA) and the International Caries Detection and Assessment System (ICDAS). We included 209 participants from the communities of Siltepec and Huehuetan, Mexico; 67% were women.
Results
The results of the ELCSA were mild FI in 43% (n = 91), moderate FI in 22% (n = 45), and severe FI (n = 6) in 3%; 32% had food security. The ICDAS results were initial decay with a mean of 6.22, moderate decay with a mean of 1.81, and extensive decay with a mean of 1.77.
Conclusions
In this study, the FI level was lower than in other rural populations in Mexico. The level of dental caries found was expected for this population.
Clinical Relevance
Food insecurity is associated with dental caries. Food insecure individuals have a higher probability of severe dental caries. Identifying these individuals and addressing the factors related to food insecurity can be useful in rural communities.
Hold It Close: Male Octopus Hold Their Hectocotylus Closer to Their Body
Authors: Weertman Willem , Scheel David
Published: February 2023

The right third arm of the male octopus is the hectocotylized arm. This arm is modified by anatomy specialized to hold and transfer sperm packets to the female, and lacks suckers at the distal end. Male octopus may be distinguished by the skilled eye from their habit of holding their hectocotylus closer to their body in a protective manner, although this observation has never been described quantitatively. We utilized a three-step process of data annotation, pose estimation model training, and model inference to show that this common observation is true of Octopus rubescens. In 2338 images, the eyes, mantle tip, and arm tips of 2 male (n = 1152) and 3 female (n = 1085) octopuses were annotated by an experimenter. These images were then used to train a DeepLabCut pose estimation model which achieved a RMSE of 1.78 cm. This model was then used to annotate 11.4 hours (n = 408985 images) of 4 female and 8 male octopuses moving across the middle of a large aquarium. We then compared the human annotated data, and the model inference data separately. In both datasets we compared the arm tip to eye centered point distances, as well as the octopus centric arm tip 90% kernel density estimation area. In both the training dataset and the model inference datasets we found a common result. Male O. rubescens hold their third to the right arm closer to their body than all seven other arms while the females do not.
Fabrication of a Uniform Chromate Conversion Coating on Zn Alloy for Improved Corrosion Resistance in Humid Environments
Authors: Ha Seonghye , Eun Jakyung , Choi Changhoon , Cho Soohyoun , Jeon Sangmin
Published: February 2023

We developed a facile method to produce a uniform chromate conversion (CC) coating on zinc alloy-plated steel substrates (ZS). When an acidic CC solution is applied to ZS (C-ZS), zinc is dissolved and chromium ions are reduced to form a chromate coating. In localized areas where zinc is excessively dissolved, zinc hydroxide particles are formed, which hinders the formation of a uniform chromate film, leaving the areas vulnerable to further corrosion (i.e., the formation of dark spots) when exposed to high humidity conditions. To suppress the excessive dissolution of zinc, the ZS surface was pretreated with thiolated polyethylene oxide to form a hydrophilic self-assembled monolayer. A more uniform protective CC coating was obtained on the pretreated ZS, resulting in superior corrosion resistance under high humidity conditions.
Organic Dots-PVA as a Platform for Wound Dressing
Authors: Afkhami Hamed , Oskouie Iman Menbari , Mohammadi Leili , Dezfuli Amin Shiralizadeh
Published: February 2023

We utilize a new nanocomposite material to give a report about a new platform for wound dressing. It is worth mentioning synergistic mixing graphene quantum dots (as a type of organic dots (ODs)) and polyvinyl alcohol (PVA) are materials participating in fabrication of the nanocomposite mentioned. We brought staphylococcus aureus as a gram-positive bacterium and pseudomonas aeruginosa as a gram-negative bacterium into play to optimize their antibacterial activity. We evaluated Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for OD/PVA nanocomposite. Our optimizations resulted as a persistent level against methicillin-resistant staphylococcus aureus (MRSA) in higher ratios of OD. Vitro studies and MTT assay were used for determination the optimum ratio of OD to PVA. We quantified burned wound infection models and the colony forming units CFUs in the burn wound which were in vivo studies by a standard colony counting method. Finally, the results show the mechanism of antibacterial activity of nanocomposite described as a contact mediated oxidative stress induction.
Early Prediction of Sepsis in Intensive Care Patients Using the Machine Learning Algorithm NAVOY® Sepsis, a Prospective Randomized Clinical Validation Study
Authors: Persson Inger , Macura Andreas , Becedas David , Sjövall Fredrik
Published: February 2023

Background

The objective of this study was to prospectively validate, in an ICU setting, the prognostic accuracy of the machine learning sepsis prediction algorithm NAVOY® Sepsis. The algorithm uses, on an hourly basis, 4 hours of input for up to 20 routinely collected vital parameters, blood gas values, and lab values, to predict the development of sepsis in the coming hours.

Methods

Patients aged 18 years or older admitted to the ICU at Skåne University Hospital Malmö from December 2020 to September 2021 were recruited in the study, with all available ICU beds monitored with the algorithm NAVOY® Sepsis. A total of 304 patients were randomized into one of two groups: Algorithm group with active sepsis alerts, or Standard of care. NAVOY® Sepsis made silent predictions in the Standard of care group, in order to evaluate its performance without disturbing the outcome. The study was blinded, i.e., study personnel did not know to which group patients were randomized. The healthcare provider followed standard practices in assessing possible development of sepsis and intervening accordingly. The patients were followed-up in the study until ICU discharge.

Results

In this study, NAVOY® Sepsis could predict the development of sepsis, according to the Sepsis-3 criteria, three hours before sepsis onset with high performance: accuracy 0.79; sensitivity 0.80; and specificity 0.78. The primary analysis was performed on all patients from the Standard of care group that had enough data for the algorithm to make a prediction 3 hours before sepsis onset (n = 85).

Conclusions

The accuracy, sensitivity, and specificity were all high, validating the prognostic accuracy of NAVOY® Sepsis in an ICU setting, including Covid-19 patients.

Trial registration

Registered at ClinicalTrials.gov September 30, 2020; NCT04570618.
A concept of computerized accelerometers
Authors: Xu Peiliang
Published: February 2023

Accelerometers are supposed to be physical instruments for measuring the acceleration of a moving object. Although huge technological advance is made in hardware of accelerometers over more than one century, accelerometers have been persistently designed and fabricated mechanically under the framework of forward problems of damped mass-spring systems. However, accelerometers are essentially inverse ill-posed source problems from the mathematical point of view, implying that small measurement errors of equivalent displacements are inherently amplified significantly such that accelerations output from accelerometers can become extremely noisy, numerically incorrect and physically meaningless in the case of high sampling rates. The ill-posedness of accelerometers cannot be rigorously solved mechanically but is always implicitly circumvented approximately. As a result, accelerometers theoretically can only produce approximate outputs of acceleration. Here we present the concept of computerized accelerometers in distinguishment of mechanical ones by applying regularization to compute accelerations from equivalent displacements. The acceleration is rigorously reconstructed mathematically as a solution to the inverse ill-posed source problem of acceleration. The concept of computerized accelerometers theoretically warrants precise measurement of acceleration without approximation, is valid for nonlinear damping as well and provides a turning point for accelerometers from a mechanical approximation to a fully rigorous computerized instrument.
WITHDRAWN: Keratinized epithelium, an indication of provisional matrix formation and early implant placement in the aesthetic area: An animal study
Authors: ren chengyan , chen weihui , chen jiangpin , mao chuanqing , liao caiyu , liu jianan
Published: February 2023

Objective: This study aimed to determine the relationship between provisional matrix (PM) and keratinized epithelium (KE) and to treat KE as an indication for early implant placement according to its healing process. In addition, a healing pattern when an implant was inserted into the PM was illustrated.
Material and Methods: Male ICR mice (n=6) were sacrificed at d1, d2, d3, d4 and d6 after left upper incisor extraction. The extraction sockets were subjected to clinical, histological and immunohistochemistry evaluation and statistical analysis. Afterward, an implant was inserted into the PM according to previous result.
Result: Sockets were occupied mainly by PM with the highest expression of osteocalcin (OC, P<0.05) and relatively high levels of CD34 and Runx2 when KE reached its fusion on sockets. The coverage of KE was positively correlated with OC and Runx2 expression (P<0.05). The PM surrounding the implant surface continued to heal, which made the process of osteointegration faster when compared to staged implant placement in previous studies.
Conclusion: The fusion of KE on the extraction socket, dominated by high bioactive PM, could be treated as an indication of early implant placement.
Clinical Relevance: This indication can be applied in clinical situation. The sufficient KE and formation of PM are helpful for primary wound closure and quicker osteointegration.
Evaluation of maternal anxiety and depression levels in pregnancies with fetal anomalies
Authors: Koc Bergen Laleli , Ersak Duygu Tugrul , Elmas Burak , Can Kazım Cihan , Kara Ozgur , Sahin Dilek
Published: February 2023

Purpose
This study aimed to document depression and anxiety levels in pregnant women with intrauterine fetal anomalies based on objective measurement inventories, raise awareness of this issue and provide the necessary support to patients.
Methods
Forty pregnant women between the ages of 18–41 who were diagnosed with a major fetal anomaly, and decided their pregnancy to continue were included in the study group. Forty pregnant women with a healthy fetus and gestational week and maternal age matched with the study group were included as the control group. The Beck Depression Inventory (BDI) and the Spielberger State-Trait Anxiety Inventory (STAI) were applied to pregnant women.
Results
Anxiety and depression levels were compared between pregnant women diagnosed with an intrauterine fetal anomaly and the control group. The mean BDI score was statistically significant in the study group (P = 0.008). In the STAI scoring, the mean state anxiety level (P<0.001) and the mean trait anxiety score was (P = 0.001) and found to be statistically significant in the study group.
Conclusion
The depressive symptom scores and the state and trait anxiety levels of pregnant women with the intrauterine fetal anomaly, increased compared to the healthy pregnant women. These women should be provided with professional psychological support and necessary medical assistance during this difficult period.
Curcumin Loaded Mesoporous Silica Nanoparticles: A Novel Therapeutic Strategy for Neurochemical Disorders
Authors: Pathak Adarsh Kumar , Singh Bhuwanendra
Published: February 2023

Background: Curcumin is extracted from the rhizomes of Curcuma longa and is an ideal candidate to treat neurological disorders. We aim to design a molecule containing curcumin-loaded mesoporous silica nanoparticles for brain delivery. Curcumin-loaded mesoporous silica nanoparticles are synthesized and evaluated via physiochemical properties, Fourier transform infrared analysis, ultraviolet, scanning electron microscopy, and X-ray diffraction analysis.
Results: Curcumin-loaded mesoporous silica nanoparticles outperformed standard in terms of physiochemical properties. Fourier transform infrared analysis confirms curcumin's successful incorporation into the mesoporous silica cells, where the quaternary carbon has an absorption band at 1521.22 cm-1 and CH2 at 2858.4 cm-1. Also, the drug loading was confirmed through scanning electron microscopy and particle size determination techniques because the sizes of unloaded and loaded particles are different from each other. So, the result is clear evidence of the loading of curcumin onto the prepared nanoparticle. X-ray diffraction analysis confirms drug entrapment within the silica nanoparticle: there is no additive peak of the drug in the final hexagonal channel of the loaded nanoparticle.
Conclusions: Curcumin-loaded mesoporous silica nanoparticles for brain delivery were successfully synthesized, and afterward they were able to treating neurological disorders.
18 F-FDG-PET/CT based deep learning model for fully automated prediction of pathological grading for pancreatic ductal adenocarcinoma before surgery
Authors: Zhang Gong , Bao Chengkai , Liu Yanzhe , Wang Zizheng , Du Lei , Zhang Yue , Wang Fei , Xu Baixuan , Zhou S. Kevin , Liu Rong
Published: February 2023

Background ：The determination of pathological grading has a guiding significance for the treatment of pancreatic ductal adenocarcinoma（PDAC）patients. However, there is a lack of an accurate and safe method to obtain pathological grading before surgery. The aim of this study is to develop a deep learning（DL）model based on 18F-FDG-PET/CT for a fully automatic prediction of preoperative pathological grading of pancreatic cancer.
Results ：A total of 370 PDAC patients from January 2016 to September 2021 were collected retrospectively. All patients underwent 18F-FDG-PET/CT examination before surgery and obtained pathological results after surgery. A DL model for pancreatic cancer lesion segmentation was first developed using 100 of these cases and applied to the remaining cases to obtain lesion regions. After that, all patients were divided into training set, validation set and test set according to the ratio of 5:1:1. A predictive model of pancreatic cancer pathological grade was developed using the features computed from the lesion regions obtained by the lesion segmentation model and key clinical characteristics of the patients. Finally, the stability of the model was verified by 7-fold cross-validation.The Dice score of the developed PET/CT based tumour segmentation model for PDAC was 0.89. The area under curve (AUC) of the PET/CT-based DL model developed on the basis of the segmentation model was 0.74, with an accuracy, sensitivity, and specificity of 0.72, 0.73, and 0.72, respectively. After integrating key clinical data, the AUC of the model improved to 0.77, with its accuracy, sensitivity, and specificity boosted to 0.75, 0.77, and 0.73, respectively.
Conclusion ：To the best of our knowledge, this is the first deep learning model to end-to-end predict the pathological grading of PDAC in a fully automatic manner, which is expected to improve clinical decision making.
Sonographic evaluation of axillary lymph node status in newly diagnosed breast cancer patients: A prospective study
Authors: Dawood Shawnam Nasih , Jamal Aska Faruq
Published: February 2023

Background: Accurate assessment of axillary lymph node status is important for breast cancer staging and treatment. Sonography can detect metastatic lymph nodes with varying degrees of sensitivity and specificity, while its routine use in the preoperative assessment of axillary lymph nodes remains controversial. The aim of this study was to assess the diagnostic accuracy of pretreatment axillary sonography in our clinical setting and to determine whether sonographic evaluation of the axilla as a tool for regional staging of breast cancer should be performed routinely in all cases.
Methods: The study recruited 185 women with histologically confirmed breast cancer from September 2021 to December 2022. Axillary ultrasound was performed on all patients to assess lymph node status using predetermined criteria. The ultrasound findings were compared to the histopathology results.
Results: Axillary sonography had 94.1% sensitivity, 87.7% specificity, 95.5% positive predictive value, 96.0% negative predictive value, and 92.4% accuracy in detecting metastatic lymph nodes in newly diagnosed breast cancer patients. In comparison to benign axillae, malignant axillae were significantly more likely to meet the lymph node criteria for "lobulated or irregular margin," "round or irregular shape," "focal or eccentric cortical thickening ≥3 mm," "totally replaced cortex," and "non-hilar blood flow" (p < 0.001).
Conclusions: Pretreatment sonography of the axilla had a high accuracy rate and a good outcome in the evaluation of lymph node status in newly diagnosed breast cancer patients, and it should be performed routinely in all cases.
Trial registration: Not applicable
The influence of the preoperative albumin to alkaline phosphatase ratio on OS in postradical colorectal cancer and the construction of a nomogram prediction model
Authors: Jiang Wenliang , Li Zhenchi , Xun Feng , Xia Yong , Hu Haoran , Liu Yujun , Zhao Zhibin , Wang Honggang
Published: February 2023

Objective
The albumin to alkaline phosphatase ratio (AAPR) is a newly developed blood biomarker that has been reported to have prognostic value in several types of cancers. The aim of this study was to investigate the predictive value of AAPR in overall survival after radical colon cancer surgery in patients with stage I-III colorectal cancer (CRC).
Methods
The clinical data of 221 eligible patients with stage I ~ III CRC were retrospectively analysed. A series of survival analyses were performed to assess the prognostic value of AAPR. Univariate and multifactorial Cox analyses were performed to identify independent risk factors. Columnar graph prediction models were further constructed based on independent risk factors such as AAPR, and their predictive properties were validated.
Results
The optimal cutoff value of preoperative AAPR for postoperative OS in patients undergoing laparoscopic radical CRC was 0.495 as shown by univariate and multifactorial Cox regression analysis. The factors of age ≤ 65 years, TNM stage I-II, tumour grading (high/medium differentiation), CEA ≤ 5 and AAPR ≥ 0.495 were associated with better OS (P < 0.05).
Conclusions
Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR < 0.495 was an independent risk factor for decreased postoperative OS.
Study of process of removing burrs from group holes in TC4 titanium alloy plate by non-synchronous rotation
Authors: Jiao Anyuan , liu Jie , Yang Ziyu , Zhang Yulong , Zhang Jialong
Published: February 2023

It is very important to remove the entrance and exit burrs of group holes in TC4 titanium alloy plate. In order to improve the efficiency, a novel method of removing burrs by non-synchronous rotation of opposite rotating magnetic pole is proposed by magnetic abrasive finishing (MAF). The influence of force change on the abrasive particles, magnetic field intensity and magnetic field gradient on the burrs removal under the relative rotation angle were studied. Meanwhile, the parameters are optimized through the experiment of non-synchronous rotation, which are magnetic pole speed, abrasive particle size and abrasive filling amount by response surface methodology (RSM). By using the method of non-synchronous rotation, the constant magnetic field distribution is improved, and the renewal of the cutting edge of magnetic abrasive particles is accelerated. Based on the investigation of rotating grinding of opposite four magnetic poles, when the rotation speed of magnetic pole I is 600r/min, the best process parameters are obtained as follows: the rotating speed of magnetic pole II is 800 r/min, and the particle size is 250 µm, abrasive filling amount is 30g. The exit burrs height decreased from 200.4 µm to 14.5 µm by 92.7%, and the entrance burrs height decreased from 180.5 µm to 10.5 µm by 94.2%. The analysis of the experiment results shows that the relative speed of the magnetic pole is faster, the splashing of abrasive particles is easier, and the lower the grinding efficiency. On the contrary, if the relative speed is smaller, the burrs removal will be more difficult. However, the impact of size of abrasive particles and the amount of abrasive filling on the burrs height is insignificant. In the process of non-synchronous rotation grinding, the entrance and exit burrs are removed at the same time, so the removal amount is greatly increased, and the grinding efficiency is improved. According to numerical simulation and experimental analysis, non-synchronous rotation grinding technology is verified, which provides a theoretical basis for the burrs removal technology.
Electric Vehicle in Smart Grid Integrated Photovoltaic Environment with Storage System
Authors: MANISSEGARANE SUVEDHA , RAJAN CHRISTOBER ASIR
Published: February 2023

This research introduces a novel hybrid sliding mode controller integrated with the artificial neural network (SMC-ANN) used for purpose of real power exchange using Intelligence Power Management System (IPMS). This paper's purpose is to explore the transient and steady state voltage, transient current, transient power of EV, along with the EV torque and EV speed. In giving a nonlinear signal that simulates the network to "glide" across a cross-section of its normal behavior, sliding mode control is a nonlinear control strategy that affects a dynamic of a nonlinear system. The setup consists of utility grid, integrated Photovoltaic source (PV) energy with Battery Storage System (BSS). A high gain DC/DC boost converter is implemented to interface BSS to the DC-bus. The Power Conditioning System receives the DC output voltage from the PV panel (PCS). These converters' bidirectional nature offers the benefit of power transfer between storage systems, loads, and PV systems. The results obtained using newly developed algorithm is compared with the conventional sliding mode controller (SMC) and it is seen that the a newly developed algorithm produced better outcomes than the conventional one. Simulation is performed using MATLAB software.
National Survey on the Availability of Oncology Palliative Care Services at Tertiary General and Cancer Hospitals in China
Authors: Li XiaoMei , Wang Xin Shelley , Huang Haili , Liu Miao , Wu YiNan , Qiu JiaoJiao , Zhang Boran , Hui David
Published: February 2023

Purpose: The nationwide survey studied the level of palliative care (PC) access for Chinese patients with cancer among cancer care providers either in tertiary general hospitals or cancer hospitals in China.
Methods:Using a probability-proportionate-to-size method, local tertiary general hospitals with oncology departments were identified to match cancer hospitals. A PC program leader or a designee per hospital reported the PC services, including staffing, inpatient and outpatient services, education, and research, based on questions adapted from a previous national survey on PC. The primary outcome was availability of a PC service.
Results: From responders, most hospitals reported that some type of PC service was available (84.3% of tertiary general hospitals, 82.8% of cancer hospitals), although named as “comprehensive cancer care”, “pain and symptom management” or “supportive care”. However, cancer hospitals were significantly more likely than tertiary general hospitals to have a PC department or specialist (34.1% compared with 15.5%, p<0.001). The most popular services were pain consultation (>92%), symptom management (>77%), comprehensive care plans (~60%), obtaining advanced directives and do-not-resuscitate (DNR) orders (~45%), referrals to hospice (>32%), and psychiatric assessment (>25%). Cancer hospitals were also more likely than tertiary general hospitals to report having inpatient beds for PC (46.3% compared with 30.5%; p=0.010), outpatient PC clinics (28.0% compared with 16.8%; p=0.029), educational programs (18.2% compared with 9.0%, p=0.014), and research programs (17.2% compared with 9.3%, p<0.001).
Conclusion: Cancer hospitals have greater availability of PC than do tertiary general hospitals in China. Our findings highlight opportunities to further increase the PC capacity in Chinese hospitals.
The Examination of Fetal Myocardium and Maternal and Fetal Features of Pregnancy Complicated by Gestational Diabetes Mellitus
Authors: Pál Zoltán , Kádas Zsófia , Németh Gábor , Surányi Andrea
Published: February 2023

Purpose:
We examined the morphological factors affecting the growing foetus’ heart, the fetal and maternal relations of pregnancies complicated by diabetes mellitus. We seaked the severity of myocardium hyperplasia is in correlation with infant respiratory distress syndrome and cardiac failure. Our study was a prospective case- control study of pregnancies complicated by diabetes mellitus produce fetal myocardium hyperplasia.
Methods:
Two ultrasound examinations were carried out on 84 pregnant women, in accordance with the selection criteria (different types of diabetes mellitus and controll cases).
The first ultrasound examination was carried out between the 24-28th weeks, the second between the 33-38th weeks of pregnancy. During the examinations we measured and averaged the fetal sizes, the estimated fetal weight, the quantity of amniotic fluid and the thickness of the ventricles and interventricular septum. Besides, we collected data from pregnant women in connection with the symptoms of diabetes mellitus, plus followed the outcome of these pregnancies. We compared these data against the our control group and a literature reference group.
Results:
Regarding the fetal myocardium and the interventricular septum, significantly higher values were registered compared to the control group, and 21% of the infants are macrosomic, 16% of them were born with intrauterine growth restriction.
Conclusions:
Based on the examinations we concluded that more complications occurred to foetuses and infants of obese pregnant women and those with diabetes mellitus than in the control groups. Thus, following the fetal myocardium’s parameters in the perinatal outcome of the mother’s glucose system’s discrepancies can be a well-applicable filtering method.