bluuebunny/crossref_metadata_2025 huggingface dataset:
First 3D Printed IH-Type Linac Structure—Proof-of-Concept for Additive Manufacturing of Linac RF Cavities
Authors: Hähnel Hendrik , Ratzinger Ulrich
Published: January 2022

Additive manufacturing (AM or “3D printing”) has become a powerful tool for the rapid prototyping and manufacturing of complex part geometries. Especially interesting for the world of particle accelerators is the process of the 3D printing of stainless steel (and copper) parts. We present a first prototype of a 433 MHz IH-type linac cavity with an internal drift tube structure manufactured by metal 3D printing. The prototype cavity has been constructed to act as a proof-of-concept for the technology. In this paper we present the concept of the cavity as well as first results of vacuum testing and materials testing.
A Propensity Score Analysis of Early and Long-Term Outcomes of Retrograde Arterial Perfusion for Endoscopic and Minimally Invasive Heart Valve Surgery in Both Young and Elderly Patients
Authors: Elhassan Hind , Abdelbar Abdelrahman , Taylor Rebecca , Laskawski Grzegorz , Saravanan Palanikumar , Knowles Andrew , Zacharias Joseph
Published: January 2022

(1) Background: Minimal invasive cardiac surgery via right anterolateral thoracotomy for heart valve surgery and other intracardiac procedures proven to have lower postoperative complications. We aim to compare the neurological complications and post-operative outcomes in two cohort groups as well as survival rates up to 5 years postoperatively; (2) Methodology: Retrospective observational study for patients who had minimally invasive cardiac valve surgery with retrograde femoral arterial perfusion between 2007 and 2021 (n = 596) and the categorized patients into two groups based on their age (≥70 years old and below 70). Propensity match analysis was conducted. The primary endpoint consisted of major postoperative complications and the secondary endpoint was the long-term survival rate. (3) Results: There was no difference between the two groups in terms of postoperative outcomes. Patients ≥ 70 years old had no increased risk for neurological complications (p = 0.75) compared with those below 70 years old. The mortality rate was also not significant between the two groups (p = 0.37) as well as the crude survival rates. (4) Conclusions: The use of retrograde femoral arterial perfusion in elderly patients is not associated with increased risk compared to the younger patients’ group for a spectrum of primary cardiac valve procedures. Hence, minimally invasive approaches could be offered to elderly patients who might benefit from it.
Emerging Technologies for Dentin Caries Detection—A Systematic Review and Meta-Analysis
Authors: Serban Christa , Lungeanu Diana , Bota Sergiu-David , Cotca Claudia C. , Negrutiu Meda Lavinia , Duma Virgil-Florin , Sinescu Cosmin , Craciunescu Emanuela Lidia
Published: January 2022

This systematic review and meta-analysis aimed at assessing the diagnostic accuracy of emerging technologies, such as laser fluorescence (LF), transillumination, light-emitting diode devices, optical coherence tomography (OCT), alternating current impedance spectroscopy, fluorescence cameras (FC), photo-thermal radiometry, and modulated luminescence technology. In vivo and in vitro results of such non-ionizing, non-invasive, and non-destructive methods’ effectiveness in non-cavitated dentin caries detection are sometimes ambiguous. Following the PRISMA guidelines, 34 relevant research articles published between 2011–2021 were selected. The risk of bias was assessed with a tool tailored for caries diagnostic studies, and subsequent quantitative uni- and bi-variate meta-analysis was carried out in separate sub-groups according to the investigated surface (occlusal/proximal) and study setting (in vivo/in vitro). In spite of the high heterogeneity across the review groups, in vitro studies on LF and FC proved a good diagnostic ability for the occlusal surface, with area under the curve (AUC) of 0.803 (11 studies) and 0.845 (five studies), respectively. OCT studies reported an outstanding performance with an overall AUC = 0.945 (four studies). Promising technologies, such as OCT or FC VistaProof, still need well-designed and well-powered studies to accrue experimental and clinical data for conclusive medical evidence, especially for the proximal surface. Registration: INPLASY202210097.
Identifying Predictive Bacterial Markers from Cervical Swab Microbiota on Pregnancy Outcome in Woman Undergoing Assisted Reproductive Technologies
Authors: Villani Annacandida , Fontana Andrea , Barone Stefano , de Stefani Silvia , Primiterra Mariangela , Copetti Massimiliano , Panebianco Concetta , Parri Cristiana , Sciannamè Natale , Quitadamo Pasqua Anna , Tiezzi Alessandra , Santana Liliana , Maglione Annamaria , D’Amato Federica , Perri Francesco , Palini Simone , Pazienza Valerio
Published: January 2022

Background and aims: Failure of the embryo to implant causes about three-fourths of lost pregnancies. Female genital tract microbiota has been associated to Assisted Reproductive Technologies (ART) outcomes. The objective of this study was to analyze the microbiota of human cervical swab and to correlate these findings with the ART outcomes. Materials and Methods: In this study, 88 cervical swabs were collected from women undergoing ART cycles, with various causes of infertility, at the beginning of the ART protocols. After microbial DNA extraction, V3–V4 variable regions of the 16S rRNA gene were amplified and sequenced on the Illumina MiSeq platform. PEnalized LOgistic Regression Analysis (PELORA) was performed to identify clusters of bacterial populations with differential abundances between patients with unfavorable and favorable pregnancy outcome groups, respectively. Results: We identified a core of microorganisms at lower taxonomic levels that were predictive of women’s pregnancy outcomes. Statistically significant differences were identified at species levels with Lactobacillus salivarius, Lactobacillus rhamnosus among others. Moreover the abundance of Lactobacillus crispatus and iners, respectively increased and decreased in favorable group as compared to unfavorable group, resulted within the core of microorganisms associated to positive ART outcome. Although the predominance of lactobacilli is generally considered to be advantageous for ART outcome, we found that also the presence of Bifidobacterium (together with the other lactobacilli) was more abundant in the favorable group. Discussion: Cervix is colonized by microorganisms which can play a role in ART outcomes as seen by an overall decrease in embryo attachment rates and pregnancy rates in both fertile and infertile women. If confirmed in a larger cohort, the abundance of these bacteria can be useful not only as a marker of unfavorable pregnancy outcome but also they may open the way to new interventional strategies based on genital tract microbiota manipulation in order to increase the pregnancy rates in woman undergoing assisted reproductive technologies.
Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw
Authors: Blatt Sebastian , Krüger Maximilian , Kämmerer Peer W. , Thiem Daniel G. E. , Matheis Philipp , Eisenbeiß Anne-Katrin , Wiltfang Jörg , Al-Nawas Bilal , Naujokat Hendrik
Published: January 2022

Background: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous platelet concentrate as a possible additive in surgical therapy to optimize vascularization and, subsequently, resolution rates. Material and Methods: A non-interventional, prospective, multicenter study was conducted, and all patients with stage I-III MRONJ, undergoing antiresorptive therapy for an oncological indication, were included. The necrosis was treated surgically without (study arm A) or with (arm B) the addition of an autologous platelet concentrate (platelet-rich fibrin, PRF). Results: After 5, 14, and 42 days postoperative, wound healing (primary outcome: mucosal integrity) as well as downstaging, pain perception, and oral health-related quality of life (secondary outcome) were assessed via clinical evaluation. Among the 52 patients included, primarily with MRONJ stage I and II, the use of PRF as an additive in surgical therapy did not display a significant advantage for wound healing (p = 0.302), downstaging (p = 0.9), pain reduction (p = 0.169), or quality of life (p = 0.9). Summary: In conclusion, PRF as an adjunct did not significantly optimize wound healing. Further, no significant changes in terms of downstaging, pain sensation, and oral health-related quality of life were found.
Evaluation of Objective and Subjective Swallowing Outcomes in Patients with Dysphagia Treated for Head and Neck Cancer
Authors: Liou Hsin-Hao , Tsai Shu-Wei , Hsieh Miyuki Hsing-Chun , Chen Yi-Jen , Hsiao Jenn-Ren , Huang Cheng-Chih , Ou Chun-Yen , Chang Chan-Chi , Lee Wei-Ting , Tsai Sen-Tien , Hung David Shang-Yu
Published: January 2022

We evaluated objective and subjective swallowing function outcomes in patients with dysphagia treated for head and neck cancer (HNC) and identified risk factors for poor swallowing outcomes. Patients undergoing videofluoroscopic swallowing studies (VFSS) between January 2016 and March 2021 were divided into four groups according to primary tumor sites; post-treatment dysphagia was assessed. The penetration–aspiration scale (PAS) and bolus residue scale (BRS) were used to objectively assess swallowing function through VFSS. The Functional Oral Intake Scale (FOIS) was used for subjective analyses of swallowing statuses. To account for potential confounding, important covariates were adjusted for in logistic regression models. Oropharyngeal tumors were significantly more likely to have poor PAS and BRS scores than oral cavity tumors, and the patients with nasopharyngeal tumors were significantly less likely to have poor FOIS scores. Old age, having multiple HNCs, and a history of radiotherapy were associated with an increased odds of poor PAS scores (for all types of swallows), poor BRS scores (for semiliquid and solid swallows), and poor FOIS scores, respectively. This indicates using only subjective assessments may not allow for accurate evaluations of swallowing function in patients treated for HNC. Using both objective and subjective assessments may allow for comprehensive evaluations.
Methodological Considerations for Setting Up Deep Brain Stimulation Studies for New Indications
Authors: Devos Jana V. P. , Temel Yasin , Ackermans Linda , Visser-Vandewalle Veerle , Onur Oezguer A. , Schruers Koen , Smit Jasper , Janssen Marcus L. F.
Published: January 2022

Deep brain stimulation (DBS) is a neurosurgical treatment with a growing range of indications. The number of clinical studies is expanding because of DBS for new indications and efforts to improve DBS for existing indications. To date, various methods have been used to perform DBS studies. Designing a clinical intervention study with active implantable medical devices has specific challenges while expanding patient treatment. This paper provides an overview of the key aspects that are essential for setting up a DBS study.
Benign Bone Tumors: An Overview of What We Know Today
Authors: De Salvo Sara , Pavone Vito , Coco Sebastiano , Dell’Agli Eleonora , Blatti Chiara , Testa Gianluca
Published: January 2022

Nonmalignant bone tumors represent a wide variety of different entities but maintain many common features. They usually affect young patients, and most can be diagnosed through imaging exams. Often asymptomatic, they can be discovered incidentally. Due to their similarities, these tumors may be challenging to diagnose and differentiate between each other, thus the need for a complete and clear description of their main characteristics. The aim of this review is to give a picture of the benign bone tumors that clinicians can encounter more frequently in their everyday work.
Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
Authors: Dziedzic Ewelina A. , Gąsior Jakub S. , Sowińska Izabela , Dąbrowski Marek , Jankowski Piotr
Published: January 2022

Coronary artery disease continues to be the leading cause of death in developed countries. Elevated mean platelet volume (MPV) is associated with an increased incidence of myocardial infarction (MI) and MI-related mortality. Vitamin D concentrations affect the level and function of platelets, which are the crucial mediator of atherothrombosis and plaque rupture. The main aim of this study was to examine the relationship of serum 25-hydroxyvitamin D (25(OH)D) levels with the platelet activity in patients with a history of an acute coronary syndrome (ACS). This prospective study recruited 268 patients with a history of MI who underwent coronary angiography due to the suspicion of another ACS. Serum 25(OH)D concentration was determined by electrochemiluminescence. Platelet activity was assessed using the MPV and platelet-large cell ratio (P-LCR) parameters. There was no significant difference in MPV and P-LCR values between patients diagnosed with subsequent MI and patients with chronic coronary syndrome (CCS). A significantly lower level of 25(OH)D was demonstrated in patients who had another MI compared to those with CCS (p < 0.05). No significant correlation of 25(OH)D concentrations with platelet activity parameters values was found. The subgroup of patients with consecutive MI was characterized by significantly lower serum vitamin D levels, but this was not related to the analyzed parameters of platelet activity.
The Rapid Implementation of Ad Hoc Tele-Critical Care Respiratory Therapy (eRT) Service in the Wake of the COVID-19 Surge
Authors: Pierce Margarete , Gudowski Steven W. , Roberts Karsten J. , Jackominic Anthony , Zumstein Karen K. , Shuttleworth Amanda , Ho Joshua , Susser Phillip , Parikh Alomi , Chandler John M. , Huffenberger Ann Marie , Scott Michael J. , Hanson C. William , Laudanski Krzysztof
Published: January 2022

A 24/7 telemedicine respiratory therapist (eRT) service was set up as part of the established University of Pennsylvania teleICU (PENN E-LERT®) service during the COVID-19 pandemic, serving five hospitals and 320 critical care beds to deliver effective remote care in lieu of a unit-based RT. The eRT interventions were components of an evidence-based care bundle and included ventilator liberation protocols, low tidal volume protocols, tube patency, and an extubation checklist. In addition, the proactive rounding of patients, including ventilator checks, was included. A standardized data collection sheet was used to facilitate the review of medical records, direct audio–visual inspection, or direct interactions with staff. In May 2020, a total of 1548 interventions took place, 93.86% of which were coded as “routine” based on established workflows, 4.71% as “urgent”, 0.26% “emergent”, and 1.17% were missing descriptors. Based on the number of coded interventions, we tracked the number of COVID-19 patients in the system. The average intervention took 6.1 ± 3.79 min. In 16% of all the interactions, no communication with the bedside team took place. The eRT connected with the in-house respiratory therapist (RT) in 66.6% of all the interventions, followed by house staff (9.8%), advanced practice providers (APP; 2.8%), and RN (2.6%). Most of the interaction took place over the telephone (88%), secure text message (16%), or audio-video telemedicine ICU platform (1.7%). A total of 5115 minutes were spent on tasks that a bedside clinician would have otherwise executed, reducing their exposure to COVID-19. The eRT service was instrumental in several emergent and urgent critical interventions. This study shows that an eRT service can support the bedside RT providers, effectively monitor best practice bundles, and carry out patient–ventilator assessments. It was effective in certain emergent situations and reduced the exposure of RTs to COVID-19. We plan to continue the service as part of an integrated RT service and hope to provide a framework for developing similar services in other facilities.
Triton Field Trials: Promoting Consistent Environmental Monitoring Methodologies for Marine Energy Sites
Authors: Eaves Samantha L. , Staines Garrett , Harker-Klimeš Genevra , Pinza Margaret , Geerlofs Simon
Published: January 2022

Uncertainty surrounding the potential environmental impacts of marine energy (ME) has resulted in extensive and expensive environmental monitoring requirements for ME deployments. Recently, there have been more ME deployments and associated environmental data collection efforts, but no standardized methodologies for data collection. This hinders the use of previously collected data to inform new ME project permitting efforts. Triton Field Trials (TFiT), created at the Pacific Northwest National Laboratory by the United States (U.S.) Department of Energy, explores ways to promote more consistent environmental data collection and enable data transferability across ME device types and locations. Documents from 118 previous ME projects or ME-related research studies in the U.S. and internationally were reviewed to identify the highest priority stressor–receptor relationships to be investigated and the technologies and methodologies used to address them. Thirteen potential field sites were assessed to determine suitable locations for testing the performance of relevant monitoring technologies. This introductory paper provides an overview of how priority research areas and associated promising technologies were identified as well as how testing locations were identified for TFiT activities. Through these scoping efforts, TFiT focused on four activity areas: collision risk, underwater noise, electromagnetic fields, and changes in habitat. Technologies and methodologies were tested at field sites in Alaska, Washington, California, and New Hampshire. Detailed information on the effectiveness of the identified methodologies and specific recommendations for each of the four focus areas are included in the companion papers in this Special Issue.
Dredged Material Decision Tool (DMDT) for Sustainable Beneficial Reuse Applications
Authors: Arreola Diana , Hernandez Julian , Vesco Valeria , Reddy Krishna R.
Published: January 2022

The Dredged Material Decision Tool (DMDT) was developed by the United States Environmental Protection Agency (USEPA) to allow project managers, stakeholders, and communities to quantify environmental, economic, and social considerations of using dredged material for beneficial purposes. Dredged material may be disposed in a confined disposal facility (CDF); however, this option is unfavorable because of the finite capacity problems these facilities pose. A more sustainable option is to use dredged materials beneficially such as construction material, for habitat restoration, or for brownfield remediation projects. This study demonstrates the applicability of the DMDT to three relevant candidate projects: (1) Dog Beach, Greenwood, and Lee Street Beaches (Evanston, IL, USA); (2) New York-New Jersey Harbor (New York/New Jersey); and (3) Poplar Island (Chesapeake Bay). The DMDT requires the project information and then completion of worksheets with each criteria (biophysical environment, economic, governance, social, and built environment) ranked, weighed, and scored. The DMDT is applied for all potential alternatives and the results are then analyzed to select the best beneficial reuse alternative. It was found that for the beaches in Evanston, the most beneficial option was on-beach placement with hydraulic dredging. The best option for the New Jersey Harbor was found to be using for brownfield and landfill remediation. The best option for Poplar Island was the lateral and vertical expansion of 50% uplands and 50% wetlands. Overall, DMDT is found to be a valuable tool to facilitate the evaluation of multi-criteria based on the project-specific data and help select the best beneficial use alternative for the dredged material.
Effects of Preparedness on Successful Emergency Response to Ship Accident Pollution Using a Bayesian Network
Authors: Zhu Yini , Ma Wenqing , Feng Hongxiang , Liu Guiyun , Zheng Pengjun
Published: January 2022

With the rapid development of international trade and the fast growth of port freight volumes, the risk of ship pollution in marine areas has significantly increased. Frequent ship pollution accidents seriously endanger marine ecosystems and are extremely unfavorable to economic development and marine environmental protection. In this study, we investigate the results of emergency responses after ship pollution accidents and analyze the factors affecting a successful emergency response. A Bayesian network model of the emergency response results of ship pollution is established, and the emergency response results of ship pollution accidents in the example of Zhoushan Port are analyzed. Based on the analysis, suggestions for strengthening the emergency preparedness of Zhoushan Port are proposed. We believe that the results of this are beneficial for improving ship pollution risk management and decision making, and that they have practical significance for marine environmental protection.
Flow Characteristics and Energy Loss of a Multistage Centrifugal Pump with Blade-Type Guide Vanes
Authors: Zhai Lulu , Lu Chao , Guo Jia , Zhu Zuchao , Cui Baoling
Published: January 2022

Multistage pumps with blade-type guide vanes are widely used in offshore oil production, the petrochemical and coal-chemical industries, and nuclear power fields for its advantages of large flow rate, high pressure, and excellent operation stability. However, the internal flow of this kind of pump is complex; in particular, the hydraulic, flow, and pressure pulsation characteristics of the different stages are quite different, which has a great impact on the design and performance predictions of this kind of pump. Thus, in this paper, the hydraulic performance, unsteady flow characteristics, evolution of vortex structures and pressure pulsation characteristics in a 10 stage centrifugal pump are investigated numerically. The results show that inverse flow, jet-wake flow, and rotor-stator interaction flow are the key factors causing energy loss and efficiency decline at every stage and in the whole pump. The vortex evolution at the rotor–stator interaction regions is actually the process that the vortex structures fall off and impact on the pressure surface at the leading edge of the guide vane blade at a frequency that equals to the impeller blade passing frequency. Furthermore, under the actions of the guide vane with confluence cavity, the pressure pulsation within the final-stage guide vane contains low-frequency components with large bandwidths, which mainly results from the confluence flow disturbance at the outlet of the cylindrical guide passage.
The Environmental Effects of the Innovative Ejectors Plant Technology for the Eco-Friendly Sediment Management in Harbors
Authors: Mikac Barbara , Abbiati Marco , Adda Michele , Colangelo Marina Antonia , Desiderato Andrea , Pellegrini Marco , Saccani Cesare , Turicchia Eva , Ponti Massimo
Published: January 2022

A sediment bypassing plant based on innovative jet pump, ejectors, has been tested in the first-of-a-kind demo application at the harbor of Cervia (Italy, Northern Adriatic Sea). The ejector is a jet pump aimed to reduce sediment accumulation in navigation channels and coastal areas. Herein we present results of the first study assessing the potential ecological effects of the ejectors plant. Sediment characteristics, benthic, and fish assemblages before and after the plant activation have been analyzed in the putatively impacted (the sediment removal and discharge) areas and four control locations, one time before and two times after plant activation. Ejectors plant operation resulted in a reduction of the mud and organic matter content in the sediment, as well as in changes in shell debris amount in the impacted areas. Abundance and species richness of benthic macroinvertebrates, initially reduced in the impacted areas, probably due to the previous repeated dredging, returned to higher values during demo plant continuous operation. Higher diversity of fish fauna was observed in the study area during plant operation period. Observed dynamics of the ecological status of the marine habitat suggest that an ejectors plant could represent an eco-friendly solution alternative to dredging operations to solve harbor siltation problems.
Ultrastructural Changes in Mitochondria in Patients with Dilated Cardiomyopathy and Parvovirus B19 Detected in Heart Tissue without Myocarditis
Authors: Pawlak Agnieszka , Gewartowska Magdalena , Przybylski Maciej , Kuffner Mateusz , Wiligórska Diana , Gil Robert , Król Zbigniew , Frontczak-Baniewicz Malgorzata
Published: January 2022

Understanding the meaning of parvovirus B19 (PB19V) in an etiology of dilated cardiomyopathy (DCM) is difficult. Viruses change the dynamics of the mitochondria by interfering with the mitochondrial process/function, causing the alteration of mitochondrial morphology. In this study, the ultrastructural changes in the mitochondria in endomyocardial biopsy (EMB) samples from patients with DCM and PB19V were determined. Methods: The PB19V evaluation was performed in EMB specimens by real-time PCR in 20 patients (age: 28 ± 6 years). The biopsy specimens were examined by histo- and immunohistochemistry to detect the inflammatory response. The ultrastructural features of the mitochondria were evaluated by electron microscopy. Results: The presence of PB19V in the heart tissue without the presence of inflammatory process, defined according to Dallas and immunohistochemical criteria, was associated with ultrastructural changes in the mitochondria. Distinctive ultrastructural pathologies were indicated, such as the presence of mitochondria in the vicinity of the expanded sarcoplasmic reticulum with amorphous material, blurred structure of mitochondria, interrupted outer mitochondrial membrane and mitophagy. Conclusions: Extending diagnostics with ultrastructural analysis of biopsy samples provides new knowledge of the changes associated with the presence of PB19V in the heart tissue. The observed changes can be a basis for searching for the damage mechanisms, as well as for new therapeutic solutions.
Global and Local Agendas: The Milan Urban Food Policy Pact and Innovative Sustainable Food Policies in Euro-Latin American Cities
Authors: Martín Diego , de la Fuente Rosa
Published: January 2022

This paper analyzes the relationship between the construction of international agendas and new sustainable local policies. Specifically, it analyzes the framework of sustainable food policy building at global and local scales. In this sense, we explore the international agreement called the Milan Urban Food Policy Pact, and its influence on the development of local and global sustainable food-related policies through different innovative methods. To this end, the process of building the international alliance of local governments for the development of sustainable food systems is analyzed first, and secondly, its locations are investigated through the public actions and programs in three cities of the Euro-Latin American region: Madrid, Quito, and Valencia. Two conclusions are clear after our qualitative study: on one hand, local policies are designed and implemented through a double strategy: the substantive construction of the policy and its inclusion in the global agenda. On the other hand, both dimensions are fundamental and reinforce each other, specifically in the case of urban sustainable food policy.
Emergence or Grammaticalization? The Case of Negation in Kata Kolok
Authors: Lutzenberger Hannah , Pfau Roland , de Vos Connie
Published: January 2022

Typological comparisons have revealed that signers can use manual elements and/or a non-manual marker to express standard negation, but little is known about how such systematic marking emerges from its gestural counterparts as a new sign language arises. We analyzed 1.73 h of spontaneous language data, featuring six deaf native signers from generations III-V of the sign language isolate Kata Kolok (Bali). These data show that Kata Kolok cannot be classified as a manual dominant or non-manual dominant sign language since both the manual negative sign and a side-to-side headshake are used extensively. Moreover, the intergenerational comparisons indicate a considerable increase in the use of headshake spreading for generation V which is unlikely to have resulted from contact with Indonesian Sign Language varieties. We also attest a specialized negative existential marker, namely, tongue protrusion, which does not appear in co-speech gesture in the surrounding community. We conclude that Kata Kolok is uniquely placed in the typological landscape of sign language negation, and that grammaticalization theory is essential to a deeper understanding of the emergence of grammatical structure from gesture.
Multi-Planar VMAT Plans for High-Grade Glioma and Glioblastoma Targeting the Hypothalamic-Pituitary Axis Sparing
Authors: Cheung Eva Y. W. , Ng Shirley S. H. , Yung Sapphire H. Y. , Cheng Dominic Y. T. , Chan Fandy Y. C. , Cheng Janice K. Y.
Published: January 2022

Background: This study aimed to identify the better arc configuration of volumetric modulated arc therapy (VMAT) for high-grade glioma and glioblastoma, focusing on a dose reduction to the hypothalamic–pituitary axis through an analysis of dose-volumetric parameters, as well as a correlation analysis between the planned target volume (PTV) to organs at risk (OAR) distance and the radiation dose. Method: Twenty-four patients with 9 high-grade glioma and 15 glioblastomas were included in this study. Identical CT, MRI and structure sets of each patient were used for coplanar VMAT (CO-VMAT), dual planar VMAT (DP-VMAT) and multi-planar VMAT (MP-VMAT) planning. The dose constraints adhered to the RTOG0825 and RTOG9006 protocols. The dose-volumetric parameters of each plan were collected for statistical analysis. Correlation analyses were performed between radiation dose and PTV-OARs distance. Results: The DP-VMAT and MP-VMAT achieved a significant dose reduction to most nearby OARs when compared to CO-VMAT, without compromising the dose to PTV, plan homogeneity and conformity. For centrally located OARs, including the hypothalamus, pituitary, brain stem and optic chiasm, the dose reductions ranged from 2.65 Gy to 3.91 Gy (p < 0.001) in DP-VMAT and from 2.57 Gy to 4 Gy (p < 0.001) in MP-VMAT. Similar dose reduction effects were achieved for contralaterally located OARs, including the hippocampus, optic nerve, lens and retina, ranging from 1.06 Gy to 4.37 Gy in DP-VMAT and from 0.54 Gy to 3.39 Gy in MP-VMAT. For ipsilaterally located OARs, DP-VMAT achieved a significant dose reduction of 1.75 Gy to Dmax for the optic nerve. In the correlation analysis, DP-VMAT and MP-VMAT showed significant dose reductions to centrally located OARs when the PTV-OAR distance was less than 4 cm. In particular, DP-VMAT offered better sparing to the optic chiasm when it was located less than 2 cm from the PTV than that of MP-VMAT and CO-VMAT. DP-VMAT and MP-VMAT also showed better sparing to the contralateral hippocampus and retina when they were located 3–8 cm from the PTV. Conclusion: The proposed DP-VMAT and MP-VMAT demonstrated significant dose reductions to centrally located and contralateral OARs and maintained the high plan qualities to PTV with good homogeneity and conformity when compared to CO-VMAT for high-grade glioma and glioblastoma. The benefit in choosing DP-VMAT and MP-VMAT over CO-VMAT was substantial when the PTV was located near the hypothalamus, pituitary, optic chiasm, contralateral hippocampus and contralateral retina.
Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization
Authors: Song Min-Young , Cho Haneul , Lee Sora , Lee Kyung Hye , Kim Weon
Published: January 2022

Dyslipidemia, the commonest cause of cardiovascular disease, leads to lipid deposits on the arterial wall, thereby aggravating atherosclerosis. DSHT (Daeshiho-tang) has long been used as an anti-dyslipidemia agent in oriental medicine. However, the anti-atherosclerotic effects of DSHT have not been fully investigated. Therefore, this study was designed to evaluate whether DSHT could exert beneficial anti-atherosclerotic effects. We fed apolipoprotein E-deficient (ApoE-/-) mice on a high-fat diet and treated them with atorvastatin (AT) or DSHT, or the combination of DSHT and AT for 12 weeks. To determine the role of DSHT, atherosclerotic lesions in the aorta, aortic root, and aortic arch; lipids and apolipoprotein levels in serum; and macrophage polarization markers in aorta tissues were examined. We show here that the DSHT decreased the atherosclerotic plaque ratio in the aortic arch, aorta, and aortic root. DSHT also regulated lipid levels by decreasing the ApoB level and increasing the ApoA1 level. Moreover, DSHT effectively regulated cholesterol metabolism by increasing the levels of PPARγ, ABCA1 and ABCG1, and the LDL receptor genes. We further found that DSHT promoted polarization to the M2 phenotype by increasing the levels of M2 macrophage (ARG1, CD163, and PPARγ) markers. Our data suggested that DSHT enhances the anti-atherosclerotic effect by regulating cholesterol metabolism through the activation of the PPARγ signaling pathway and by promoting anti-inflammatory M2 macrophage polarization.
Oxidative Phosphorus Chemistry Perturbed by Minerals
Authors: Omran Arthur , Abbatiello Josh , Feng Tian , Pasek Matthew A.
Published: January 2022

Life is a complex, open chemical system that must be supported with energy inputs. If one fathoms how simple early life must have been, the complexity of modern-day life is staggering by comparison. A minimally complex system that could plausibly provide pyrophosphates for early life could be the oxidation of reduced phosphorus sources such as hypophosphite and phosphite. Like all plausible prebiotic chemistries, this system would have been altered by minerals and rocks in close contact with the evolving solutions. This study addresses the different types of perturbations that minerals might have on this chemical system. This study finds that minerals may inhibit the total production of oxidized phosphorus from reduced phosphorus species, they may facilitate the production of phosphate, or they may facilitate the production of pyrophosphate. This study concludes with the idea that mineral perturbations from the environment increase the chemical complexity of this system.
Review on Graphene-, Graphene Oxide-, Reduced Graphene Oxide-Based Flexible Composites: From Fabrication to Applications
Authors: Razaq Aamir , Bibi Faiza , Zheng Xiaoxiao , Papadakis Raffaello , Jafri Syed Hassan Mujtaba , Li Hu
Published: January 2022

In the new era of modern flexible and bendable technology, graphene-based materials have attracted great attention. The excellent electrical, mechanical, and optical properties of graphene as well as the ease of functionalization of its derivates have enabled graphene to become an attractive candidate for the construction of flexible devices. This paper provides a comprehensive review about the most recent progress in the synthesis and applications of graphene-based composites. Composite materials based on graphene, graphene oxide (GO), and reduced graphene oxide (rGO), as well as conducting polymers, metal matrices, carbon–carbon matrices, and natural fibers have potential application in energy-harvesting systems, clean-energy storage devices, and wearable and portable electronics owing to their superior mechanical strength, conductivity, and extraordinary thermal stability. Additionally, the difficulties and challenges in the current development of graphene are summarized and indicated. This review provides a comprehensive and useful database for further innovation of graphene-based composite materials.
Experimental and Numerical Simulation of a Radiant Floor System: The Impact of Different Screed Mortars and Floor Finishings
Authors: Almeida Ricardo M. S. F. , Vicente Romeu da Silva , Ventura-Gouveia António , Figueiredo António , Rebelo Filipe , Roque Eduardo , Ferreira Victor M.
Published: January 2022

The radiant floor system market is growing rapidly because Europe is moving toward a low-carbon economy and increased awareness about environmental sustainability and energy efficiency, stimulated by the ambitious EU Energy Efficient Directive and nZEB challenge. The high growth rate of the market share is due to the involvement of homeowners in the specifications of their living commodities, so they are thus willing to invest more at the initial stage to obtain long-term benefits and lower energy exploration costs. We performed an experimental campaign over three slabs with a hydronic radiant floor system of equal dimensions, shape, and pipe pitch with different screed mortar formulations to assess their performance throughout a heating/cooling cycle. The temperature at different heights within the interior of the screed mortars and at the surface were monitored. The results revealed that an improved screed mortar has a relevant impact on the efficiency of the system. Moreover, a three-dimensional transient heat transfer model was validated using the experimental data. The model was used to evaluate the impact of different finishing materials, namely wood, cork, ceramic, and linoleum, on the floor surface temperatures. The results showed differences of 15% in the surface temperature when using different floor finishing solutions.
The Surface Conditions and Composition of Titanium Alloys in Implantology: A Comparative Study of Dental Implants of Different Brands
Authors: Tchinda Alex Pérez , Pierson Gaël , Kouitat-Njiwa Richard , Bravetti Pierre
Published: January 2022

The success of titanium dental implants depends on their osseointegration into the bone, which is determined by the composition and surface properties of the implant in close contact with the bone. There is a wide variety of implants on the market. Is it possible to identify the implant with the best composition and surface topography for optimal osseointegration? To this aim, 13 brands of dental implants from nine distinct manufacturers have been selected and their composition and surface topography determined. The obtained results show differences between these implants, in this case, the Ssk averages of the three measurements performed on each implant were positive, or 0.4 (0.1–0.8), indicating that the roughness of all implants analyzed was primarily textured and not flat. Like Sa, we found the highest Sdr for implants subjected only to sandblasting. In addition, only the ALS-active® implant had a modified microstructure on its surface. However, analysis of the NANOTITE implant surface revealed a 1.40% presence of calcium which we consider too low to have an effect on bone formation around the implant. As a result, we have also highlighted the lack of a recognized independent standard for dental implant surface conditions and the lack of independent quality control vis-à-vis manufacturers. Of all the surface types studied, none proved more satisfactory than another.
Tuning Ferromagnetism in a Single Layer of Fe above Room Temperature
Authors: Zdyb Ryszard , Palotás Krisztián , Simon Eszter , Jaroch Tomasz , Korczak Zbigniew
Published: January 2022

The crystallographic and magnetic properties of an Fe monolayer (ML) grown on 2 ML Au/W(110) substrate are studied with spin-polarized low-energy electron microscopy, density functional theory, and relativistic screened Korringa–Kohn–Rostoker calculations. The single layer of iron atoms possesses hexagonal symmetry and reveals a ferromagnetic order at room temperature. We experimentally demonstrate the possibility of tuning the Curie temperature and the magnitude of magnetization of the Fe monolayer by capping with Au. Taking into account several structural models, the calculation results mostly show ferromagnetic states with enhanced magnetic moments of Fe atoms compared to their bulk value and a further increase in their value after covering with Au. The theoretically calculated Curie temperatures are in fair agreement with those obtained in the experiments. The calculations, furthermore, found evidence for the presence of frustrated isotropic Fe–Fe exchange interactions, and a discussion of the structural effects on the magnetic properties is provided herein.
Investigation of the Robotized Incremental Metal-Sheet Forming Process with Ultrasonic Excitation
Authors: Ostasevicius Vytautas , Paulauskaite-Taraseviciene Agne , Paleviciute Ieva , Jurenas Vytautas , Griskevicius Paulius , Eidukynas Darius , Kizauskiene Laura
Published: January 2022

During the single-point incremental forming (SPIF) process, a sheet is formed by a locally acting stress field on the surface consisting of a normal and shear component that is strongly affected by friction of the dragging forming tool. SPIF is usually performed under well-lubricated conditions in order to reduce friction. Instead of lubricating the contact surface of the sheet metal, we propose an innovative, environmentally friendly method to reduce the coefficient of friction by ultrasonic excitation of the metal sheet. By evaluating the tool-workpiece interaction process as non-linear due to large deformations in the metal sheet, the finite element method (FEM) allows for a virtual evaluation of the deformation and piercing parameters of the SPIF process in order to determine destructive loads.
Influence of Moisture Content and Wet Environment on the Fatigue Behaviour of High-Strength Concrete
Authors: Abubakar Ali Mohamed , Tomann Christoph , Aldakheel Fadi , Mahlbacher Markus , Noii Nima , Oneschkow Nadja , Drake Karl-Heinz , Lohaus Ludger , Wriggers Peter , Haist Michael
Published: January 2022

The influence of a wet environment on the fatigue behaviour of high-strength concrete has become more important in recent years with the expansion of offshore wind energy systems. According to the few investigations documented in the literature, the fatigue resistance of specimens submerged in water is significantly lower compared to that of specimens in dry conditions. However, it is still not clear how the wet environment and the moisture content in concrete influence its fatigue behaviour and which damage mechanisms are involved in the deterioration process. Here the results of a joint project are reported, in which the impact of moisture content in concrete on fatigue deterioration are investigated experimentally and numerically. Aside from the number of cycles to failure, the development of stiffness and acoustic emission (AE) hits are analysed as damage inductors and discussed along with results of microstructural investigations to provide insights into the degradation mechanisms. Subsequently, an efficient numeric modelling approach to water-induced fatigue damage is presented. The results of the fatigue tests show an accelerated degradation behaviour with increasing moisture content of the concrete. Further, it was found that the AE hits of specimens submerged in water occur exclusively close to the minimum stress level in contrast to specimens subjected to dry conditions, which means that additional damage mechanisms are acting with increasing moisture content in the concrete.
Application of Ion Exchangers with the N-Methyl-D-Glucamine Groups in the V(V) Ions Adsorption Process
Authors: Burdzy Katarzyna , Chen Yi-Gong , Lv Gui-Yuan , Chen Su-Hong , Kołodyńska Dorota
Published: January 2022

The adsorption capacities of ion exchangers with N-methyl-D-glucamine (NMDG) groups (Amberlite IRA 743, Lewatit MK 51, Purolite S110 and Purolite S108) relative to V(V) ions were tested in a batch system, taking into account the influence of various parameters, such as the adsorbent mass (0.05–0.20 g), phase contact time (1–240 min), initial concentration (10–150 mg/L), and temperature (293–333 K), as well as in a column system where the variable operating parameters were initial concentration (50, 100 mg/L), bed volume (10, 100 mL) and flow rate (0.6, 6 mL/min). Pseudo-first order, pseudo-second order, intraparticle diffusion and Boyd models were used to describe the kinetic studies. The best fit was obtained for the pseudo-second order model. The Langmuir, Freundlich and Temkin adsorption models were used to describe the equilibrium data to acquire better knowledge about the adsorption mechanism. The thermodynamic parameters were also calculated, which showed that the studied processes are endothermic, spontaneous and thermodynamically favorable. The physicochemical properties of the ion exchangers were characterized by nitrogen adsorption/desorption analyses, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray photo electron spectroscopy (XPS). The point of zero charge (pHPZC) was also determined.
Dimensionality of the Superconductivity in the Transition Metal Pnictide WP
Authors: Nigro Angela , Cuono Giuseppe , Marra Pasquale , Leo Antonio , Grimaldi Gaia , Liu Ziyi , Mi Zhenyu , Wu Wei , Liu Guangtong , Autieri Carmine , Luo Jianlin , Noce Canio
Published: January 2022

We report theoretical and experimental results on the transition metal pnictide WP. The theoretical outcomes based on tight-binding calculations and density functional theory indicate that WP is a three-dimensional superconductor with an anisotropic electronic structure and nonsymmorphic symmetries. On the other hand, magnetoresistance experimental data and the analysis of superconducting fluctuations of the conductivity in external magnetic field indicate a weakly anisotropic three-dimensional superconducting phase.
Tribological Characterization of Electrical Discharge Machined Surfaces for AISI 304L
Authors: Adnan Muhammad , Qureshi Waqar , Umer Muhammad , Botto Daniele
Published: January 2022

Surface treatments are normally carried out after machining. Surface treatment is a costly and time-consuming process. Hence, it makes sense to reduce the requirement of surface treatment as much as possible. Electrical Discharge Machining (EDM) is a frequently used machining process. EDM produces a recast layer on the surface of machined components. The tribological performance of this recast layer is not very well understood. The properties of the recast layer formed as a result of EDM depend upon the discharge current, electrodes and dielectrics. This work aims to study the effects of each on the tribological performance – in terms of the wear depth, friction coefficient, friction force and contact surface temperature of recast layers. Subsequent improvement in the quality of surfaces will significantly reduce the cost and time required to treat surfaces after machining. Hence, various combinations of discharge current, dielectrics and electrodes have been used to characterize and deduce their effects. The tribo-tests are performed in the boundary lubrication regime under pin-on-disc configuration to analyze sliding friction, contact surface temperature and the wear of the recast layers formed on AISI 304L. The surface morphology of the test pins has been performed by Scanning Electron Microscopy (SEM) before and after the tests. The results show that indeed it is possible to control the tribological performance of the recast layers by varying EDM parameters. This approach promises to be a useful methodology to improve the tribological performance of the layers formed after EDM and reduce the time and costs required for surface treatments post machining.