bluuebunny/crossref_metadata_2025 huggingface dataset:
Pendampingan Penyajian dan Pengolahan Data Demografi Kesehatan Penduduk Aparat Desa Negeri Hutumuri Kecamatan Leitimur Selatan Kota Ambon
Authors: Bension Johan Bruiyf , Kondo Lembang Ferry , Latuihamallo Carlos Salemba , Radjid Samin , Irfanullah Asrul
Published: December 2021

ABSTRAK Negeri Hutumuri merupakan desa terpadat di wilayah Kecamatan Leitimur Selatan Kota Ambon dengan jumlah penduduk mencapai 4.657 jiwa serta kepadatan penduduk sebesar 310 jiwa setiap km2. Keberadaan profil status jumlah  penduduk yang lebih besar memungkinkan peluang munculnya berbagai persoalan kependudukan khususnya kesehatan penduduk apabila tidak dikelola dengan baik. Tujuan dari program Pengabdian Kepada Masyarakat ini adalah untuk meningkatkan pengetahuan aparat desa sebagai ujung tombak pembangunan desa terkait penyajian dan pengolahan data demografi kesehatan penduduk. Metode pelaksanaan kegiatannya meliputi pelatihan dan pendampingan tentang analisis statistik data demografi kesehatan penduduk yang meliputi pengukuran dasar data demografi kependudukan desa. Hasil dari pelaksanaan kegiatan ini, dapat menunjang pemahaman, menambah pengetahuan dan pengembangan softskill aparat desa dalam mengelola statistik demografi kesehatan penduduk yang berdampak pada peningkatan kualitas pengelolaan dan penataan data kependudukan yang dapat digunakan untuk pembangunan dan mempermudah pelayanan terhadap masyarakat desa. Kata Kunci: Demografi Kesehatan Penduduk, Penyajian dan Pengolahan Data, Softskill Aparat Desa ABSTRACT Negeri Hutumuri is the most populous village in the South Leitimur Subdistrict, Ambon City, with a population of 4,657 people and a population density of 310 people per km2. The existence of a larger population status profile allows opportunities for various population problems to arise, especially population health if it is not managed properly. The purpose of this Community Service program is to increase the knowledge of village officials as the spearhead of village development related to the presentation and processing of population health demographic data. The method of implementing its activities includes training and assistance on a statistical analysis of population health demographic data which includes basic measurement of village population demographic data. The results of the implementation of this activity can support understanding, increase knowledge and develop soft skills of village officials in managing demographic health statistics of the population which have an impact on improving the quality of management and structuring of population data that can be used for development and facilitating services to village communities. Keywords: Population Health Demographics, Data Presentation, and Processing, Soft Skills for Village Officials.
Pendidikan Kesehatan Gigi Berbasis Alat Peraga Untuk Meningkatkan Peranan Guru TK Dalam Pencegahan Karies Gigi
Authors: Pratiwi Deviyanti , Salim Richentya Feiby , Stefani Rosita , Tjandrawinata Rosalina , Iskandar Bernard O. , Nadiah Najla
Published: December 2021

ABSTRAK Masalah kesehatan gigi yang sering terjadi pada anak usia sekolah yaitu karies. Kurangnya pengetahuan mengenai kesehatan gigi menyebabkan tingginya angka karies pada anak. Anak pada usia sekolah cenderung akan mencontoh perilaku gurunya, sehingga guru dapat berperan dalam meningkatkan pengetahuan kesehatan gigi pada anak usia sekolah. Pada masa pandemi ini, terdapat keterbatasan dalam memberikan edukasi secara langsung di lingkungan sekolah. Tujuan kegiatan ini yaitu  dengan pemberian edukasi kepada guru mengenai kesehatan gigi, sehingga dapat meningkatkan pengetahuan para guru dan diharapkan para guru dapat menjadi penggerak dalam meningkatkan pengetahuan mengenai kesehatan gigi pada anak usia sekolah. Metode penyuluhan dilakukan dengan pemberian materi dalam bentuk presentasi power point secara daring melalui aplikasi zoom dan penggunaan alat peraga kesehatan gigi. Hasil penyuluhan menunjukkan adanya peningkatan pengetahuan mengenai kesehatan gigi. Setelah dilakukan penyuluhan dengan metode ini, dapat disimpulkan bahwa alat peraga dianggap efektif dalam membantu keberhasilan pendidikan kesehatan gigi serta meningkatkan pemahaman dan antusias para guru TK. Kata kunci: kesehatan gigi, alat peraga, guru TK, karies gigi  ABSTRACT A dental health problem that often occurs in school-age children is caries. Lack of knowledge about dental health causes high caries rates in children. Children at school age tend to imitate the behavior of their teachers so that teachers play a role in increasing knowledge of dental health in school-age children. During this pandemic, there are limitations to providing education directly in the school environment. The aim of this activity is to provide education to teachers about dental health. So that it can increase the knowledge of teachers and it is hoped that teachers can be a pioneer in increasing knowledge about dental health in school-age children. The method was carried out by providing material in the form of an online powerpoint presentation through zoom application and the use of dental health teaching aids. The result of this activity showed an increase in knowledge about dental health. After conducting counseling, it can be concluded that the use of teaching aids is effective in contributing to the success of dental health education and increasing the understanding and enthusiasm of kindergarten teachers.  Keywords : dental health, teaching aids, kindergarten teachers, dental caries
Pelatihan Pelaksanaan Pijat Bayi Kepada Ibu Yang Memiliki Bayi di Desa Pondok Keumuning, Pondok Kelapa dan Pondok Nias
Authors: Fazdria Fazdria , Veri Nora , Mutiah Cut , Dewita Dewita
Published: December 2021

ABSTRAK Di Indonesia, meskipun sejarah pemijatan berawal dari nenek moyang masa lampau, namun pijat bayi yang diperkenalkan bukanlah pijat tradisional yang dilakukan oleh dukun bayi atau dukun pijat yang pijatannya tidak aman. Pijat bayi yang dimasyarakatkan adalah pijat modern yang memadukan antara ilmiah (kesehatan), seni, dan kasih sayang. Pijat bayi akan membuat bayi tidur lebih lelap dan meningkatkan kosentrasi kesiagaan (alertness) atau kosentrasi. Hal ini disebabkan pijatan dapat mengubah gelombang otak. Pengubahan ini terjadi dengan cara menurunkan gelombang alpha dan peningkatan gelombang beta, serta tetha yang dapat dibuktikan dengan penggunaan EEG (electro enchephalogram). Tujuan kegiatan adalah meningkatkan pengetahuan dan keterampilan ibu dalam melakukan pijat bayi di Desa Pondok Kelapa, Pondok Nias dan Pondok Kemuning Kec. Langsa Baro Kota Langsa. Metode pengabdian yang digunakan dalam kegiatan ini adalah program pendidikan masyarakat melalui edukasi dan pelatihan pijat bayi pada ibu bayi dan balita. Hasil pengabdian kepada masyarakat yang telah dilakukan oleh Dosen Prodi D-III Kebidanan Langsa pada tanggal 30 September s/d 2 Oktober 2020 didapatkan hasil mayoritas peserta pengabdian kepada masyarakat memiliki pengetahuan yang baik tentang pijat bayi yaitu sebanyak 17 orang (56,7%) dan mayoritas terampil dalam melakukan pijat bayi yaitu sebanyak 22 orang (73,3%). Kata Kunci : Pengetahuan, Keterampilan, Pijat Bayi  ABSTRACT In Indonesia, although the history of massage dates back to the ancestors of the past, the baby massage introduced is not a traditional massage performed by a baby shaman or a massage shaman whose massage is not safe. A popularized baby massage is a modern massage that blends scientific (health), art, and compassion. Baby massage will make the baby sleep better and increase alertness or concentration. This is because massage can alter brain waves. This conversion occurs by lowering alpha waves and increasing beta waves, as well as tetha which can be proven by the use of EEG (electroencephalogram). The purpose of the activity is to improve the knowledge and skills of mothers in performing baby massage in Pondok Kelapa Village, Pondok Nias, and Pondok Kemuning Kec. Langsa Baro Langsa City. The method of devotion used in this activity is a community education program through the education and training of baby massage in infants and toddler mothers. The results of community service that has been done by Lecturers of Prodi D-III Midwifery Langsa on September 30 to October 2, 2020, obtained the results of the majority of participants of community service have good knowledge about baby massage that is as many as 17 people (56.7%) and the majority are skilled in performing baby massage that is as many as 22 people (73.3%). Keywords: Knowledge, Skills, Baby Massage
Green engineering principles and application: bioremediation
Authors: Hadibarata Tony , Voijant Tangahu Bieby
Published: December 2021

The adulteration of the environment by hazardous waste, such as heavy metals, nuclear wastes, hydrocarbons, pesticides and greenhouse gases is the major serious problem which need to be reduced. Common remediation technique such as physical, chemical and biological process are being applied. Chemical process can transform and change organic contaminant of interest which is not sufficient to clean the environment, while physical technique requires additional equipment. Thus, bioremediation exist as green approach to eliminate the hazardous waste in the environment. In this review, bioremediation is comprehensively presented. Remediation process types, challenges, limitations, mechanisms, and future suggestion has been elaborated to develop bioremediation technology for future prospect.
Hubungan Iklim dengan Kinerja Pekerja di PT. Pelabuhan Indonesia (Persero) Terminal Peti Kemas Makassar
Authors: Pitaloka Adinda , Yuliati  , Mansur Sididi
Published: December 2021

Iklim Kerja adalah kombinasi dari suhu udara, kelembaban udara, kecepatan gerakan udara, Suhu nyaman orang Indonesia pada umumnya beraklimatisasi dengan iklim tropis sekitar 29°C-30°C dengan kelembaban 85%-95%. Bekerja dibawah paparan panas dengan melebihi batas normal suhu yang ditentukan akan berdampak dengan Kesehatan dan menurunnya kemampuan dalam kinerjanya. Kinerja adalah hasil kerja secara kualitas dan kuantitas yang dicapai oleh seseorang dalam melaksanakan tugas dengan tanggung jawab yang diberikan. Penelitian ini bertujuan untuk dapat mengetahui Hubungan iklim kerja dengan kinerja pekerja di PT. Pelabuhan Indonesia. Jenis penelitian ini adalag penelitian kuantitatif dengan metode observasional analitik dengan desain cross sectional study. Populasi dalam penelitian ini seluruh pekerja lapangan dan administrasi non shift dengan sampel menggunakan teknik random sampling yaitu sebanyak 37. Hasil penelitian yaitu menunjukkan bahwa bahwa uji chi-square dengan α (0,05) diperoleh nilai p= 0,002 dimana nilai p < α menunjukkan ada hubungan antara iklim kerja dengan kinerja. Dan Uji chi-square menunjukkan dengan α (0,05) diperoleh nilai p= 0,003 dimana nilai p < α menunjukkan ada hubungan antara lama paparan dengan kinerja pada pekerja di PT. Pelabuhan Indonesia IV (PERSERO) Terminal Petikemas Kota Makassar Tahun 2020. Bagi pihak PT. Pelabuhan Indonesia IV (PERSERO) Terminal Petikemas Kota Makassar untuk lebih memperhatikan kenyamanan pekerja dalam bekerja agar dapat menmaksimalkan hasil kinerja kerjanya.
La relevancia idiosincrásica de la muerte y los cementerios. Turismo en el cementerio ochocentista de Conchada (Coimbra, Portugal): públicos, motivaciones, interpretaciones y reflexiones
Authors: Dos Reis Madeira Sara Filipa
Published: December 2021

Las visitas guiadas realizadas entre noviembre de 2019 y marzo de 2020, como parte de una ruta de Turismo de Cementerio en el Cementerio de Conchada en Coimbra, Portugal, en colaboración con entidades públicas y privadas de la ciudad y en el ámbito de la Maestría en Turismo, Territorio y Patrimonio (Facultad of Arts de la Universidad de Coimbra - FLUC), a través de la entrega de cuestionarios a los visitantes, permitió comprender sus motivaciones con respecto a la demanda turística en las áreas de cementerio. Teniendo en cuenta los datos informativos adquiridos, este texto transmite reflexiones que contribuyen a la interpretación de los cementerios del siglo XIX como lugares idiosincrásicos y pedagógicos en el contexto de la memoria cultural, social e histórica como espacios vividos en un contexto de autenticidad ética, debatiendo la necesidad de desmitificar y reinterpretar su aura de ritualización cristiana para contribuir a la percepción de la muerte como un proceso holístico en los entornos patrimoniales de los cementerios.
'Taprose Temanku Sebagai Strategi Komunikasi Pemerintahan dan Pelayanan Publik Kabupaten Tuban
Authors:   Universitas Dr. Soetomo, Surabaya Indonesia, Faizah Isnaini Kun , Soekrani Tony S. ,   Universitas Dr. Soetomo, Surabaya Indonesia, Panuju Redi ,   Universitas Dr. Soetomo, Surabaya Indonesia
Published: December 2021

This study discusses government communication using applications as public services and the Tuban government communication strategy. Tuban Government has the TapRose Temanku application which is a place for the community to submit criticisms, suggestions and questions. The focus of this research is how the strategy of the Tuban government and what kind of public services the Tuban government has done through the TapRose Temanku Application. This qualitative research uses data collection techniques, interviews, observation, and documentation. The results of this research are the TapRose Temanku application is a public service conducted by the Tuban Government and is a government communication strategy. The TapRose application, my friend, attracts the public's interest because it is packaged in a simple and easy to understand way for all ages and easily accessed.
Peta Literasi Media Pemilih Pemula di Surabaya
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Setyarinata Agatha Winda , Intan Theresian ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: December 2021

This research aims to map the level of media literacy among first voters in Surabaya. 300 first-time voters were participated in this research. They are range 17 to 20 years old. The result shows that majority of first-time voters are in technical skill level. This means that they are savvy in seeking information about election through browser (2.99) as well as in saving the webpage (3.11). They are also savvy in sharing information about election (3.04) as well as in reporting the false content (3.03). The first-time voters are also literate to content about election that spread all over the internet (critical abilities). They are able to distinguish the election news which contain hoax (3.20). They are also able to verify the credibility of the news they read (2.89). The first-time voters have remark the credible sources that they trust (2.98). Although they are savvy in technical skills level and in critical abilities level, they do not adopt the communicative abilities. This means they do not participate in creating written content (1.74) and visual/audio-visual content (1.68) about the election. They tend to not repost and add caption to a content about election (1.98).
Bentho-pelagic mismatches in intertidal sandflats in relation to seasonal upwelling: the role of endobenthic ecosystem engineering
Authors: Qwabe W , Pillay D
Published: December 2021

Allochthonous transfers are ubiquitous features of marine ecosystems. While these transfers typically subsidise recipient ecosystems and increase donor control, mismatches in allochthony and biotic recipients can also occur. However, driving processes are not well understood, particularly in the context of biotic determinants in coastal ecosystems. Using a 2 yr dataset, we show that allochthonous inputs related to seasonal offshore upwelling on the west coast of South Africa do not lead to strengthening of bottom-up regulation in intertidal lagoonal sandflat ecosystems. Despite an increase in mean phytoplankton biomass by 46.4% at benthic study sites during summer upwelling seasons, benthic primary producer (microphytobenthos) biomass did not increase proportionally, and neither did consumer (macro- and meiofauna) population metrics. Unexpectedly, levels of these response variables were greater during winter downwelling periods than upwelling phases. Correlation analyses indicated that the bentho-pelagic mismatch documented in relation to upwelling may be related to coincidental increases in densities of endobenthic burrowing sandprawnsKraussillichirus kraussi, which are key ecosystem engineers, principally due to rapid sediment reworking and destabilisation. The predominantly negative correlations recorded between benthic response variables and sandprawn density align with our past experimental work, suggesting that the suppressive effect of sandprawns on benthic primary producers and consumers evident in small-scale experiments also manifests over large temporal scales, thereby overriding potential subsidising effects of upwelling. Our findings indicate that in sandflat ecosystems, endobenthic ecosystem engineers that are rapid benthic destabilisers may be important in determining responses to marine allochthonous inputs and the degree of donor control in recipient ecosystems.
STUDY THE HARMFUL EFFECTS OF SODIUM METABISULFITE ON LIVER, TESTEs, AND LIPID PEROXIDATION IN MALE MICE, (MUS MUSCULUS)
Authors: Naureen Irum , Saleem Aisha , Nawaz Attique , Javed Mahnoor
Published: December 2021

The present study was designed to
evaluate the toxic effect of Sodium metabisulfite
(SMB) on testes and liver of 8 week- old mouse,
which were grouped as control (C) and dose
group, SM (500 mg/kg B.W SMB). The
Experimental group was injected 0.1ml SM (500
mg/g B.W + 10 ml distilled water) for twenty-one
days, while a control group was given 0.1 ml water
for the same durations. Recovered testes were
subjected to morphological, morphometric, and
histological analysis. A Hormone evaluation was
also conducted. Methods Dose group SM (500
mg/kg B.W SMB) showed morphological defects
like wrinkles on the surface, shrinkage, small size,
whereas the testes of control group appeared
normal just like control (C). Morphometric
analysis of dose group SM (500 mg/g B.W SMB)
showed significant decrease in length, width and
weight of testis as compared to control group.
Blood analysis showed significantly levels of
testosterone and glutathione reductions in dose
group SM (500 mg/g B.W SMB) as compared to
the control group. While the level of
Melanodialdehyde (MDA) increased significantly
in dose group SM (500 mg/g B.W SMB) as
compare to the control group. Histological defects
were observed in testes of dose group SM (500
mg/g B.W SMB) like deshaped somniferous
tubule, degenerated spermatids, vacuolization,
rupturing of germinal epithelium, absence of
sperms in the lumen, degenerated peritubular
myoid cells, hyalinization, cluster of degenerated
spermatozoa in lumen and absence of leydig cells.
Histology of the liver showed various defects like
mitotic cells, vacuolization, degeneration of
hepatic cells and cell shrinkage, broad suicidal
spacing, absence of bile canaliculus cells,
regenerated kuppfer cell, and interrupted sheet of
hepatocytes. Conclusion - The harmful impact of
sodium metabisulfite on the liver and
reproductive system of male mice. A Sharp
decrease in the level of testosterone was formed to
be a key factor for studied deformation in
morphology, morphometry, and histol
PERCEPTIONS OF COVID-19 INFODEMIC AND CONSPIRACY THEORIES IN AFRICA: INSIGHT FROM BENIN CITY RESIDENTS IN NIGERIA
Authors: Precious Nwaoboli Emeke
Published: December 2021

This study was an examination of the
perceptions of COVID-19 infodemic and
conspiracy theories in Africa: Insight from Benin
City residents in Nigeria. The objectives of the
study were to find out the perception of COVID19 infodemics and conspiracy theories in Africa;
find out the various COVID-19 infodemics and
conspiracy theories in Africa;and examine the
level of dorminance of COVID-19 infodemics and
conspiracy theories in Africa. The study
population was 544, 499. Four hundred copies of
questionnaire were distributed while 389 were
retrieved and found usable. Findings from the
study showed that there is still a huge dominance
and acceptance of COVID-19 infodemics and
conspiracy theories in Africa. The study therefore
recommended that Africans should learn to
always verify all COVID-19 information story
they see and hear especially on social media as
some of them are mere conspiracy theories and
infodemics.
APPRAISAL OF THE IMPLEMENTATION OF LAND-USE REGULATIONS ON COMMERCIAL PROPERTY DEVELOPMENT IN ILORIN, NIGERIA
Authors: Olasunkanmi Otunola AbdulAkeem , Adedayo Adebayo Michael
Published: December 2021

The implementation of land use regulations on
commercial property development is extremely important
because of benefits abound in it for the society. Ilorin the
capital of Kwara state, Nigeria is experiencing influx of
many residents which gave rise to series of urban
challenges. This paper appraised the implementation of
land use regulations on commercial property development
in Ilorin, Nigeria. The study adopted survey research
design and census method was adopted for the commercial
properties and Estate Surveying and Valuation firms in
the study area. Questionnaires were distributed to 26
practicing Estate firms in Ilorin Kwara State, 110 and 39
selected landlords / occupiers of commercial properties in
Gambari-Ipata-Emir’s road and Government Reserved
Area in Ilorin, Nigeria. Out of which 24 questionnaires
(92%) and 110 (100%), 36 (92 %) were returned and
found useful for the study. Data collected were analysed
using descriptive statistics of cross tabulation and
inferential statistics of Independent Sample t – Test and
test of hypothesis. The research revealed that the p-values
were all greater than 0.01 which led to the acceptance of
null hypothesis that the level of implementation of land use
regulations on commercial property development does not
vary in the study area. The study conclude that there were
hindrances to effective implementations of land use
regulations on commercial property development across
the study areas, and if not corrected will continue to affect
the welfare of the citizens, ease of commercial activities,
will lead to falling in commercial property’s rental value,
falling in urban aesthetic value, and an increase in
externalities. The study recommended proper government
intervention in providing better resources to improve the
level of monitoring and enforcement of land use
regulations on commercial property development.
HIGH STRENGTH CONCRETE USING PURIFIED FLY ASH
Authors: V. Jadhav Alankar , S. Sapkal Ajit , Nagendra M.V
Published: December 2021

For the shelter requirements of widely
spreading population civil industry also spreading
enormously. With different and advanced construction
techniques numbers of materials used in this construction
procedure are also developed and used in general practice.
Cement is base product for every type of construction. It is
made from natural material with special factory procedure.
This cement or cementitious material has strength up to 53
MPa. But while practicing higher grade concretes which
has strength more than 65 MPa we have to use some special
processed material mixture with cement. During this
material study we have to use material purified fly ash. This
fly ash possess some good qualities like extra silica
percentage, more fine and better surface area. So it is better
option than factory waste fly ash and silica fume to achieve
desired strength of concrete. With different trial mixes we
can use it in general practice.
A MACHINE LEARNING FRAMEWORK BASED ON VARIOUS NETWORK TRAFFIC CHARACTERISTICS TO IDENTIFY AND CLASSIFY THE DEFAULT BEHAVIOR OF IOT DEVICES ON A NETWORK
Authors: Bhavani Shankar Pagalla , Reddy Maramreddy Yogi , Venkata Durga Gayatri Padala S
Published: December 2021

The Internet of Things (IoT) is being
well acquire to the next era of revolutionary
generations amongst the new technologies. IoT
technology being hailed so hard we had to stop in
our society, smart homes, enterprises, and smart
cities. Dynamics of smart one’s are increasingly
being equipped with a profusion of IoT devices.
Due to the tremendous upgradation of knowledge
in various aspects impresarios of such smart
environments may not even be fully aware of
their working nature or principles of IoT devices,
assets and functioning properly safe from cyberattacks. In this paper, we addressing this
challenge by developing a robust framework for
IoT device classification using traffic
characteristics obtained at the level of network
level. As a part of robust framework, firstly, we
have a tendency to instrument a smart
environment with 28 completely different IoT
devices, spanning cameras, lights, plugs, motion
sensors, appliances and health-monitors. We
have a tendency to collect and synthesize traffic
traces from this framework infrastructure for a
period of 6 months, a type of subset of which we
release as open data for the community to use.
Second, we have to present or gifts the insights
into the underlying network traffic
characteristics using statistical and applied
mathematical attributes such as activity cycles,
port numbers, signaling patterns and cipher
suites. Third, we have a tendency to develop a
multi-stage machine learning based classification
algorithm and demonstrate its ability to identify
specific IoT devices with over 99% accuracy
based on their network flow of activity. Finally,
we have a tendency to discuss the trade-offs
between cost, speed, and performance involved in
deploying the classification network framework
in real-time. Our study paves the way for
impresarios of smart environments to monitor
their IoT devices and assets for presence,
functionality, and cyber-security without
requiring any specialized devices or protocols.
HISTORY OF NIGERIA LAND USE ACT (AN OVERVIEW)
Authors: Stephen Abatan , Lawal Musibau , Omolara Bankole , Racheal Babarinde
Published: December 2021

The 1978 Land Use Act has a provision that
vests ownership of Nigerian land in state/public sector
management (LUA). Injustice, loss of land market, lack
of fairness, transparency, and inaccessibility of land to
the urban/rural poor have all plagued the LUA's
implementation over the years. As a result, the critiques
vary from an insufficient payment of compensation to
the State's improper application of the LUA's
requirements, as well as the isolation of LG councils and
the urban poor in the execution of the LUA. These
comments are supported by the physical inspection and
contact with stakeholders in the studied area's land
rights. These comments are supported by the physical
inspection and contact with stakeholders in the studied
area's land rights. The LUA has been proven to be too
complicated for the average person to understand, to be
exceedingly expensive and oppressive, and to be geared
toward governmental needs. The study's goal is to
examine present methods in public sector land
management in Minna, Nigeria's Niger State, and to
come up with a feasible and effective solution to the
problems. Respect for existing property rights, access to
financing markets, and a favorable policy climate are all
recommended for success. The fiscal feasibility of the
current government's land reform agenda in Nigeria
must be considered.
A COMPREHENSIVE REVIEW ON GENETICS AND ITS IMPACT ON HUMAN DISEASES
Authors: Kalra Prachi
Published: December 2021

In 1866, when Mendel was carrying out his
pea plant experiments in the monastery, nobody
could predict what was to come. A genius whose
ideas were appreciated after 34 years of their
discovery, quite literally planted the seeds for the
genetics that we’re familiar with, today. The
important breakthrough was the completion of The
Human Genome Project in 2003, which meant that
scientists now had the genetic dictionary in their
hands for an in-depth review of DNA and
associated mutations. Eventually, the picture
started to become clearer and our earlier
speculation about the role of family history and
environment in genetic disorders, now had
concrete proof.
The modern-day geneticist aims to identify,
diagnose, and treat gene related conditions more
efficiently than ever. This article surveys the
different ways in which genetic disorders manifest
themselves, their causative mutations, as well as
early detection and treatment
HYBRID NEURO-WAVELET MODEL FOR SHORT TERM LOAD FORECASTING
Authors: M. Gimonkar Ravindra , Kapgate D A
Published: December 2021

- Accuracy of the electricity load forecasting is
crucial in providing better cost effective risk management
plans. This paper proposes a Short Term Electricity Load
Forecast (STLF) model with a high forecasting accuracy.
A cascaded forward BPN neuro-wavelet forecast model is
adopted to perform the STLF. The model is composed of
several neural networks whose data are processed using a
wavelet technique. The data to be used in the model is
electricity load historical data. The historical electricity
load data is decomposed into several wavelet coefficient
using the Discrete wavelet transform (DWT). The wavelet
coefficients are used to train the neural networks (NNs)
and later, used as the inputs to the NNs for electricity load
prediction. The Levenberg-Marquardt (LM) algorithm is
selected as the training algorithm for the NNs. To obtain
the final forecast, the outputs from the NNs are
recombined using the same wavelet technique.
DISTRICT WISE ANALYSIS OF COVID-19 PANDEMIC TRENDS DURING SECOND WAVE IN THE STATE ANDHRA PRADESH, INDIA USING SEIR-RGS MODEL
Authors: Subrahmanyam MSLB , Hem Kumar Vajjha
Published: December 2021

— Andhra Pradesh is one of the south Indian states in
India and having 13 districts. This is one of the most Covid-19
effected state in India during first and second waves. In India
district is the major administrative block for implementing
government policies and schemes under control of district
collector. So, estimating or forecasting trends in district level
more important than state wise or entire country wise. In this
paper we are proposing Susceptible, Exposed, Infected and
Recovered – Regression and Grid Search (SEIR-RGS) model
for analyzing Covid -19 district wise trends during second
wave. The SEIR-RGS, initially collects daily wise covid data
for each district from Department of Health, medical and
family welfare, AP and estimates the model parameters like
contact rate, incubation rate and recovery rate. To calculate
recovery rate the proposed model uses regression technique
between daily active cases vs cumulative recoveries. The
present model uses two phases for estimating contact rate and
incubation rate using grid search approach. After that the
proposed method calculates the infectious period, incubation
period and basic reproduction of infection in all 13 districts to
analyze trends in the state during second wave and also to
predict possibility of third wave in each district.
Liver Transplantation in Patients with Acute-onChronic Liver Failure: Challenging the Limits
Authors: Diaz Juan Manuel , Mauro Ezequiel , Gutierrez-Acevedo Maria Nelly , Gadano Adrian , Marciano Sebastian
Published: December 2021

Acute-on-chronic liver failure (ACLF) is one of the main causes of death on the waiting list. Liver transplantation (LT) is the only curative treatment for patients with ACLF and therefore it should be considered in all cases. However, the applicability of LT in patients with ACLF is challenging, given the scarcity of donors and the high short-term mortality of these patients. Organ allocation has traditionally been prioritised according to the model for end-stage liver disease (MELD) system. However, the accuracy of MELD score is limited in patients with ACLF. In this article, the authors review the outcomes of patients with ACLF before and after LT, highlighting its clinical course, the feasibility of LT in the sickest patients, the role of the organ allocation system, and possible indicators of futility.
Toplumsal Bilimlerde Metodolojinin Sınırları: İktisat Bağlamında Bir Tartışma
Authors: ASLAN Vedat Ulvi
Published: December 2021

Özellikle iktisatta olmak üzere, toplumsal bilimlerde nicel çözümlemelere yer verilmektedir. Ancak toplumsal ilişkilerin ve bunlardan türeyen kategorilerin nicelleştirilmesi, özünde bir soyutlamayı
gerektirmektedir. Bu soyutlama gerçek ve gerekli olmakla birlikte, soyutlamayı mümkün kılan toplumsal ilişkilerin özünün göz ardı edilmesine neden olmaktadır. Bu durumda, nicelleştirilebilir görüngüler temelinde yapılan çözümlemeye ilişkin yöntem tartışmaları, bu görüngüleri mümkün kılan ilişkileri ele alamamakta, yapılan şey toplumsal ilişkilerin değil, onun belirli bir biçiminin çözümlenmesiyle sınırlı kalmaktadır. Bu durum, metodoloji tartışmalarında yansımasını bulmakta, doğrulanabilir olmayı tek bilimsel ölçüt görme eğilimindeki çözümlemeler, gerçek soyutlamayı mümkün ve gerekli kılan ilişkileri ele alma kapasitesinden yoksun kalırken, metodoloji tartışmalarında ilişkilerin esasıyla ilgili içeriğin ele alınmadığı görülmektedir. İktisadi çözümlemede karşımıza çıkan iki örnek, ücret ve fiyat kavramlarıdır. Bu kavramlar nicel boyutlarıyla sınırlı bir çözümlemeye konu oldukları ölçüde, bunları ortaya çıkaran ilişkiler, hem çözümlemeye hem metodoloji tartışmalarına dışsal kalmaktadır.
Method for diagnosing non-alcoholic liver steatosis
Authors: Bulatova I. A. , Miftakhova A. M. , Gulyaeva I. L.
Published: December 2021

Purpose of the study.Development of a non-invasive method for the diagnosis of non-alcoholic hepatic steatosis.

Material and methods.The study involved 21 patients with confrmed non-alcoholic hepatic steatosis on ultrasound examination with an average age of 42.1 ± 10.1 years. The control group consisted of 10 apparently healthy individuals. The following indicators were determined: body mass index (BMI), the level of gamma-glutamyl transpeptidase (GGTP), vasculoendothelial growth factor (VEGF) and interleukin-6 (IL-6) in serum, and the steatosis index (IS) was calculated using the formula IS = –1.2390 + 0.0575 × BMI + 0.0064 × GGTP +0.0006 × VEGF + 0.0001 × IL-6. The index of the presence of hepatic steatosis according to liver ultrasound data was used as a dependent variable.

Results.According to the examination results, BMI and serum concentrations of GGTP, VEGF, and IL-6 in patients with steatosis were signifcantly higher than in the control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, respectively), which indicates the presence of cholestasis syndrome, signs of inﬂammation and endothelial dysfunction. The correlation coeffcient between BMI and the presence of non-alcoholic hepatic steatosis was 0.9; between GGTP and the presence of steatosis was 0.80; between VEGF and the presence of steatosis was 0.85; between IL-6 and the presence of steatosis was 0.80. The predictive value of each parameter of the model was assessed using a scale of values of the area under the ROC-curve (AUC). The model is effective (multiple correlation coeffcient R = 0.809; the share of the inﬂuence of the sum of the factors included in the model is R2 • 100 = 65.5%), statistically signifcant (criterion F = 12.318; p < 0.0001) and has excellent diagnostic characteristics.

Conclusion.The proposed non-invasive method makes it possible to diagnose hepatic steatosis with a sensitivity of 95.2% and a specifcity of 97.0%: with IS equal to 0.5 or more, the presence of non-alcoholic hepatic steatosis is diagnosed, with IS less than 0.5 is not.
Increased Arm Swing and Rocky Surfaces Reduces Postural Control in Healthy Young Adults
Authors: Mezher Cezar , Siragy Tarique , Nantel Julie
Published: December 2021

Fall-induced injuries can stem from a disruption in the postural control system and place a financial burden on the healthcare system. Most gait research focused on lower extremities and neglected the contribution of arm swing, which have been shown to affect the movement of the center of mass when walking. This study evaluated the effect of arm swing on postural control and stability during regular and rocky surface walking. Fifteen healthy young adults (age = 23.4 ± 2.8) walked on these two surfaces with three arm motions (normal, held, and active) using the CAREN Extended-System (Motek Medical, Amsterdam, NL). Mean, standard deviation and maximal values of trunk linear and angular velocity were calculated in all three axes. Moreover, step length, time and width mean and coefficient of variation as well as margin of stability mean and standard deviation were calculated. Active arm swing increased trunk linear and angular velocity variability and peak values compared to normal and held arm conditions. Active arm swing also increased participants’ step length and step time, as well as the variability of margin of stability. Similarly, rocky surface walking increased trunk kinematics variability and peak values compared to regular surface walking. Furthermore, rocky surface increased the average step width while reducing the average step time. Though this surface type increased the coefficient of variation of all spatiotemporal parameters, rocky surface also led to increased margin of stability mean and variation. The spatiotemporal adaptations showed the use of “cautious” gait to mitigate the destabilizing effects of both the active arm swing and rocky surface walking and, ultimately, maintain dynamic stability.
Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
Authors: Chen Ming , Qin Jianzhong , Lu Shijun , Zhang Feng , Zuo Baoqi
Published: December 2021

Nanofibers as elements for bioscaffolds are pushing the development of tissue engineering. In this study, tussah silk was mechanically disintegrated into nanofibers dispersed in aqueous solution which was cast to generate tussah silk fibroin (TSF) nanofiber mats. The effect of treatment time on the morphology, structure, and mechanical properties of nanofiber mats was examined. SEM indicated decreasing diameter of the nanofiber with shearing time, and the diameter of the nanofiber was 139.7 nm after 30 min treatment. These nanofiber mats exhibited excellent mechanical properties; the breaking strength increased from 26.31 to 72.68 MPa with the decrease of fiber diameter from 196.5 to 139.7 nm. The particulate debris was observed on protease XIV degraded nanofiber mats, and the weight loss was greater than 10% after 30 days in vitro degradation. The cell compatibility experiment confirmed adhesion and spreading of NIH-3T3 cells and enhanced cell proliferation on TSF nanofiber mats compared to that on Bombyx mori silk nanofiber mats. In conclusion, results indicate that TSF nanofiber mats prepared in this study are mechanically robust, slow biodegradable, and biocompatible materials, and have promising application in regenerative medicine.
A Multi-Task Deep Learning Method for Detection of Meniscal Tears in MRI Data from the Osteoarthritis Initiative Database
Authors: Tack Alexander , Shestakov Alexey , Lüdke David , Zachow Stefan
Published: December 2021

We present a novel and computationally efficient method for the detection of meniscal tears in Magnetic Resonance Imaging (MRI) data. Our method is based on a Convolutional Neural Network (CNN) that operates on complete 3D MRI scans. Our approach detects the presence of meniscal tears in three anatomical sub-regions (anterior horn, body, posterior horn) for both the Medial Meniscus (MM) and the Lateral Meniscus (LM) individually. For optimal performance of our method, we investigate how to preprocess the MRI data and how to train the CNN such that only relevant information within a Region of Interest (RoI) of the data volume is taken into account for meniscal tear detection. We propose meniscal tear detection combined with a bounding box regressor in a multi-task deep learning framework to let the CNN implicitly consider the corresponding RoIs of the menisci. We evaluate the accuracy of our CNN-based meniscal tear detection approach on 2,399 Double Echo Steady-State (DESS) MRI scans from the Osteoarthritis Initiative database. In addition, to show that our method is capable of generalizing to other MRI sequences, we also adapt our model to Intermediate-Weighted Turbo Spin-Echo (IW TSE) MRI scans. To judge the quality of our approaches, Receiver Operating Characteristic (ROC) curves and Area Under the Curve (AUC) values are evaluated for both MRI sequences. For the detection of tears in DESS MRI, our method reaches AUC values of 0.94, 0.93, 0.93 (anterior horn, body, posterior horn) in MM and 0.96, 0.94, 0.91 in LM. For the detection of tears in IW TSE MRI data, our method yields AUC values of 0.84, 0.88, 0.86 in MM and 0.95, 0.91, 0.90 in LM. In conclusion, the presented method achieves high accuracy for detecting meniscal tears in both DESS and IW TSE MRI data. Furthermore, our method can be easily trained and applied to other MRI sequences.
Biomimetic Methacrylated Gelatin Hydrogel Loaded With Bone Marrow Mesenchymal Stem Cells for Bone Tissue Regeneration
Authors: Li Jun , Wang Wenzhao , Li Mingxin , Song Ping , Lei Haoyuan , Gui Xingyu , Zhou Changchun , Liu Lei
Published: December 2021

Large-segment bone defect caused by trauma or tumor is one of the most challenging problems in orthopedic clinics. Biomimetic materials for bone tissue engineering have developed dramatically in the past few decades. The organic combination of biomimetic materials and stem cells offers new strategies for tissue repair, and the fate of stem cells is closely related to their extracellular matrix (ECM) properties. In this study, a photocrosslinked biomimetic methacrylated gelatin (Bio-GelMA) hydrogel scaffold was prepared to simulate the physical structure and chemical composition of the natural bone extracellular matrix, providing a three-dimensional (3D) template and extracellular matrix microenvironment. Bone marrow mesenchymal stem cells (BMSCS) were encapsulated in Bio-GelMA scaffolds to examine the therapeutic effects of ECM-loaded cells in a 3D environment simulated for segmental bone defects. In vitro results showed that Bio-GelMA had good biocompatibility and sufficient mechanical properties (14.22kPa). A rat segmental bone defect model was constructed in vivo. The GelMA-BMSC suspension was added into the PDMS mold with the size of the bone defect and photocured as a scaffold. BMSC-loaded Bio-GelMA resulted in maximum and robust new bone formation compared with hydrogels alone and stem cell group. In conclusion, the bio-GelMA scaffold can be used as a cell carrier of BMSC to promote the repair of segmental bone defects and has great potential in future clinical applications.
A Sequential Therapeutic Hydrogel With Injectability and Antibacterial Activity for Deep Burn Wounds’ Cleaning and Healing
Authors: Wang Sizhen , Li Jie , Ma Zhiqiang , Sun Linhong , Hou Lei , Huang Ying , Zhang Yunchang , Guo Beibei , Yang Feng
Published: December 2021

As a severe clinical challenge, escharotomy and infection are always the core concerns of deep burn injuries. However, a usual dressing without multifunctionality leads to intractable treatment on deep burn wounds. Herein, we fabricated a sequential therapeutic hydrogel to solve this problem. Cross-linked by modified polyvinyl alcohol (PVA-SH/ε-PL) and benzaldehyde-terminated F127 triblock copolymers (PF127-CHO), the hydrogel demonstrated excellent mechanical properties, injectability, tissue adhesiveness, antibacterial activity, biocompatibility, and satisfactory wound cleaning through both in vitro and in vivo assays. Additionally, based on the conception of “sequential therapy,” we proposed for the first time to load bromelain and EGF into the same hydrogel in stages for wound cleaning and healing. This work provides a strategy to fabricate a promising wound dressing for the treatment of deep burn wounds with injectability and improved patients’ compliance as it simplified the process of treatment due to its “three in one” characteristic (antibacterial activity, wound cleaning, and healing effects); therefore, it has great potential in wound dressing development and clinical application.
Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis
Authors: Lv Zi , Xiong Li-ling , Qin Xian , Zhang Hua , Luo Xin , Peng Wei , Kilby Mark D. , Saffery Richard , Baker Philip N. , Qi Hong-bo
Published: December 2021

Graphical Abstract

Lv et al. show that trophoblastic GRK2 deficiency could promote placenta dysfunction and PE-like phenotype by activating necroptosis in trophoblasts, then inducing cytokine disturbance in circulation.
A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Therapeutic Response of Gastric Cancer
Authors: Xiao Shilang , Liu Xiaoming , Yuan Lingzhi , Wang Fen
Published: December 2021

Background: Accumulating literature demonstrates that long noncoding RNAs (lncRNAs) are involved in ferroptosis and gastric cancer progression. However, the predictive value of ferroptosis-related lncRNAs for prognosis and therapeutic response is yet to be elucidated in gastric cancer (GC).

Method: The transcriptomic data and corresponding clinical information of GC patients were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) database. The association between ferroptosis-related lncRNAs and ferroptosis regulators was analyzed by Spearman correlation analysis. Then, we established a risk predictive model based on the ferroptosis-related lncRNAs using multivariate Cox regression analysis. Furthermore, we performed correlation analysis for the risk score and characteristics of biological processes, immune landscape, stromal activity, genomic integrity, drug response, and immunotherapy efficacy.

Results: We constructed a 17-ferroptosis-related-lncRNA signature via multivariate Cox analysis to divide patients into two groups: low- and high-risk groups. The low-risk group was linked to prolonged overall survival and relapse-free survival. The risk score had good predictive ability to predict the prognosis of GC patients compared with other clinical biomarkers. We found that the high-risk group was associated with activation of carcinogenetic signaling pathways, including stromal activation, epithelial-mesenchymal-transition (EMT) activation, and immune escape through integrated bioinformatics analysis. In contrast, the low-risk group was associated with DNA replication, immune-flamed state, and genomic instability. Additionally, through Spearman correlation analysis, we found that patients in the high-risk group may respond well to drugs targeting cytoskeleton, WNT signaling, and PI3K/mTOR signaling, and drugs targeting chromatin histone acetylation, cell cycle, and apoptosis regulation could bring more benefits for the low-risk group. The high-risk group was associated with poor immunotherapy efficacy.

Conclusion: Our study systematically evaluated the role of ferroptosis-related lncRNAs in t tumor microenvironment, therapeutic response, and prognosis of GC. Risk score–based stratification could reflect the characteristic of biological processes, immune landscape, stromal activity, genomic stability, and pharmaceutical profile in GC patients. The ferroptosis-related lncRNA signature could serve as a reliable biomarker to predict prognosis and therapeutic response of patients with GC.