bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relevance of Critical Thinking from the Perspective of Professional Training
Authors: Mihail Rarita
Published: June 2022

In today's complex world, influenced by information bombardment and rapid technological development, professional training cannot remain limited to the idea of passing knowledge. There is a need to shift the students’ view towards the true spirit of research, which targets the scientific thought on certain social phenomena, and to form critical thinking skills to produce effective individuals in the current labour market, who not only receive information, but go further and analyze problems in the workplace, presenting solutions to identified problems and applying these solutions in concrete situations. For this reason, critical thinking is considered a top skill, being highly appreciated by the business world and organizations. But to think critically is a capacity that does not develop by itself, it must be practiced and encouraged in a correct learning environment. Critical thinking has become one of the most important educational goals, which must be achieved by the different educational institutions through all the programs studied by students in the different educational cycles, but also by students in the university environment. Starting from this, this article analyses the types of specific actions which target the introduction of the abilities of critical thinking in the training activities in Romania, and in society in its entirety, by identifying the setbacks encountered, and the limits of such an endeavour.
Intimacy scale of the emotional dimension: construct validation
Authors: Immanuel Euckie
Published: June 2022

This work is interested in emotional intimacy, and hereby reports on the construct validation of the Intimacy Scale of the Emotional Dimension (ISOTED). Two hundred and ninety-nine persons participated in the validation study, aged 17-56. Two other scales were used for various aspects of the construct validation process. They included that The Dyadic Communication Assessment Scale and the Simple Screening Instrument for Substance Abuse. Exploratory Factor analysis revealed 14 items, two factors – Emotional congruence, alpha = .97, and Emotional Vacuum, alpha = .92. Confirmatory Factor Analysis confirmed the two factors with good indices, giving credence to the factorial validity of the ISOTED. Further, the ISOTED has convergent, as well as criterion-related validity. Therefore, the ISOTED is a valid and reliable scale with robust psychometric properties. It promises to be useful in clinical and research contexts for assessing intimate relationships.
 
Keywords: Emotional Intimacy; Scale; Reliability; Validity; Relationship;
Massive perspective: Lived experiences of obese and overweight students in Cainta Senior High School Rizal, Philippines
Authors: Martos Gerald S.
Published: June 2022

A growing body of literature is pointing out that obese and overweight adolescents are subjected to serious and prevalent physical, social, medical, and psychological consequences. To provide richer literature about the lived experiences of obese and overweight students, this qualitative study was conducted.  This phenomenological study aims to explore the lived experiences of obese and overweight students (OOS) in Cainta Senior High School. A semi-structured questionnaire was used to gather data from eight purposively-chosen respondents. Collaizi’s seven-step method was then utilized to analyze the data collected from focus group discussion (FGD).  Data explicitation revealed the development of four themes. It may be helpful to educate individuals involved in stigma reduction interventions such as teachers, friends, and/or family members. Establishing a Fitness Club which will involve OOS to ensure the adequacy of physical activities in school is imperative. For future researchers, a qualitative study must also be done on why losing weight is difficult. 
 
Keywords: Lived experiences; obese; overweight; phenomenology.
CURRENT PROBLEMS OF PROVIDING FREQUENCY AND POWER REGULATION RESOURCES TO IPS OF UKRAINE
Authors: Olefir D. , Babich V. , Blinov I.
Published: June 2022

The main requirements for the volume of ancillary services in the IPS of Ukraine are considered. In particular, the requirements for the frequency maintenance reserve and frequency recovery reserves. The influence of renewable energy sources (RES) on the balance of production and consumption of electricity is shown. The place of hydroelectric power plants in the modern conditions of functioning of the IPS of Ukraine and the structure of the ancillary services market  is considered. It is shown that in fact, according to the existing structure of production facilities in the IPS of Ukraine, only HPP and HPSP units are able to balance the fast-changing load schedule of renewable energy sources due to their high maneuverability. Features of operation of HPP units in normal and emergency modes are given. Prospects for the development of ancillary services in the IPS of Ukraine are identified. The need to update the regulatory framework was noted according to the results of the analysis of the peculiarities of the functioning of the IPS of Ukraine,. It is noted that it is necessary to clarify the Transmission System Code in terms of updating the requirements for the minimum required reserves for frequency control in the IPS of Ukraine given the growing share of unregulated RES in the structure of production capacity. Some measures are proposed to increase the level of operational security of regimes in the conditions of further development of RES and plans for synchronization of UES of Ukraine with ENTSO-E energy systems.
TRANSIENT ANALYSIS IN THREE-PHASE ELECTRICAL CIRCUITS WITH DISTRIBUTED PARAMETERS AND INTERFACIAL CONNECTION ON THE EXAMPLE OF HIGH-VOLTAGE CABLE LINE
Authors: Lobodzinskiy V. , Chybelis V.
Published: June 2022

The analysis of transients in three-phase electric circuits is carried out, which allowed to consider changes of transient components of currents and voltages of each phase of three-phase cable power line and to estimate the level of overvoltage and amplitude of short-circuit currents in screens taking into account transposition. Using the MatLab/Simulink program, software tools and methods for numerical calculation of transient electromagnetic processes in the designed 330 kV cable line were developed to analyze the level of voltages on the screens and currents in the cable cores at different switching modes. The calculations of a specific 330 kV cable line with a length of 13 km, laid for the first time in Ukraine for the power supply of the electric steel complex, were carried out. The calculation of the emerging transient electromagnetic processes in such a line under different conditions of its connection to the three-phase power supply network is carried out. Many types of switching overvoltages are subject to limitation. Feasibility studies of overvoltage protection measures include assessment of statistical characteristics of damage due to damage, simple or extraordinary repair of electrical equipment of the cable line, as well as due to violation of the technological process by consumers. The above determines the relevance of modeling and analysis of electromagnetic processes that occur when connecting and switching cable lines in ultra-high-voltage three-phase electrical circuits. This allows us to recommend the results of work to develop methods for determining the allowable and emergency modes of similar three-phase cable transmission lines and the choice of rational circuit design solutions in their design. Analyzing the transients in the mode of single-phase short circuit, we can conclude that to select the optimal lengths of the transposition sections of cable screens, it is necessary to consider single-phase short circuit mode, as in this mode there are unacceptable overvoltages on cable screens and currents in three-phase cable lines.
COMPLEX ESTIMATION OF THE POWER CONSUMPTION EFFICIENCY IN INDUSTRY
Authors: Bratkovska K. , Shram A.
Published: June 2022

The peculiarities of mathematical models’ application of electricity consumption for estimation of energy use efficiency in enterprises which provides operation of energy efficiency control systems by comparing actual energy consumption with planned ones are analyzed. Differentiated unit consumption rates were calculated by the chief power engineer's department of the enterprise based on calculated data received from the energy services of the divisions. These rates were used to identify factors that affect electricity consumption. At the same time, the existing equipment in the workshop, its capacity, load and working time were taken into account to fulfill the given production plan, including account repairs, maintenance and the implementation of energy-saving measures. It is determined that in the analysis of energy consumption by individual divisions of the enterprise for each factor enterprises do not always take into account the interconnection of processes taking place in different departments, and as a result, the effectiveness of using mathematical models for both forecasting electricity consumption and assessing consumption efficiency is reduced. Taking into account the factors that are considered as important in determining the electricity consumption of individual units according to the observations of the Department of Chief Energy (taking into account their mutual influence), the regression equation was found and evaluated. It was established that the use of refined mathematical models with a narrowed confidence interval expands the potential for energy saving of the enterprise and prompts a more detailed analysis, the search for additional controlled and uncontrolled factors of influence on the efficiency of electricity consumption.

An analysis of mathematical models of power consumption of the catching workshop and the boiler turbine workshop as the main consumers showed that the factors affecting electricity consumption are uncontrolled. By changing them it is possible to achieve a decrease in electricity consumption, but not an increase in its efficiency. The main disadvantage of mathematical models of electricity consumption used in the enterprise to forecast the volume of electricity consumption and estimate the efficiency of energy use is their additivity for various departments. It resulted in a regression model of electricity consumption to estimate the relationship between the energy consumption value and their defining parameters (coke production, coke gas, steam production, electricity). The estimation of the electricity consumption model, using the coefficient of determination, has done.
DETERIORATION OF THE HEALTH OF SCHOOL AND PRESCHOOL CHILDREN BY CHANGING THE TECHNOGENIC LOAD ON THE TERRITORY OF SCHOOLS AND KINDERGARTENS
Authors: Chepel A. , Kofanova О. , Pidgornyy А.
Published: June 2022

The paper analyzes the state of the car fleet of Ukraine and provides statistical numbers of cars in 2020. The aim of the work is to assess the contamination of heavy metals in soils located on the territory of children's educational institutions in Kyiv, near highways, and to calculate the health risk from exposure to heavy metals. The structure of the housing stock of Ukraine by years of construction is shown. The influence of heavy metals on human health is given. Soil samples taken on the territory of the city of Kyiv at playgrounds for the content of pollutants were studied. A study has been conducted on the health risks of school and preschool children from the effects of soil contamination with heavy metals in the surrounding areas near educational institutions, where children spend most of their lives. The hydrogen index of aqueous extracts was determined, the sulfate-chloride content was analyzed, and the presence of basic cations and anions was determined. The urgency of the work lies in the problem of soil contamination in schools and kindergartens, which requires constant review. It is important to constantly monitor the soil cover within the surrounding areas, to take samples from the surface layer and at depths. It is also important to consider this issue when designing and building new facilities.
Aromatic maturity is a cornerstone of terroir expression in red wine
Authors: Van Leeuwen Cornelis , Barbe Jean-Christophe , Darriet Philippe , Destrac-Irvine Agnès , Gowdy Mark , Lytra Georgia , Marchal Axel , Marchand Stéphanie , Plantevin Marc , Poitou Xavier , Pons Alexandre , Thibon Cécile
Published: June 2022

Harvesting grapes at adequate maturity is key to the production of high-quality red wines. Viticulturists, enologists, and wine makers define several types of maturity, including physiological maturity, technological maturity, phenolic maturity, and aromatic maturity. Physiological maturity is a biological concept. Technological maturity and phenolic maturity are relatively well documented in the scientific literature, being linked to quantifiable compounds in grape must. Articles on aromatic maturity are scarcer. This is surprising, because aromatic maturity is, probably, the most important of the four in determining wine quality and typicity, including terroir expression, i.e.  the identifiable taste of wine in relation to its origin. Optimal terroir expression can be obtained when technological, phenolic, and aromatic maturity are reached at the same time, or within a short time frame. This is more likely to occur when the ripening takes place under mild temperatures, neither too cool, nor too hot.Aromatic expression in wine can be driven, in order from low to high maturity, by green, herbal, spicy, floral, fresh fruit, ripe fruit, jammy fruit, dried fruit, candied, or cooked fruit aromas. Green and cooked fruit aromas are not desirable in red wines, while the levels of other aromatic nuances contribute to the typicity of the wine in relation to its place of origin. Wines produced in cool climates, or on cool soils in temperate climates, are likely to express herbal or fresh fruit aromas, while wines produced under warm climates, or on warm soils in temperate climates, may express ripe fruit, jammy fruit, or candied fruit aromas.This article reviews the state of the art of compounds underpinning the aromas of wines obtained from grapes harvested at different stages of maturity. Advances in the understanding of how aromatic maturity shapes terroir expression and how it can be manipulated by variety choices and management practices, under current and future climatic conditions, are shown. Early ripening varieties perform better in cool climates and late ripening varieties in warm climates. Additionally, maturity can be advanced or delayed by different canopy management practices or training systems. Timing of harvest also impacts aromatic expression of the produced wine. Gaps in the literature are highlighted to guide future directions of research.
Local influence of climate on grapevine: an analytical process involving a functional and Bayesian exploration of farm data time series synchronised with an eGDD thermal index
Authors: Laurent Cécile , Le Moguédec Gilles , Taylor James , Scholasch Thibaut , Tisseyre Bruno , Metay Aurélie
Published: June 2022

Climate influence on grapevine physiology is prevalent and this influence is expected to increase with climate change. Climate influence on grapevine physiology can vary depending on the terroir. A better understanding of these local terroir variations is likely to be achieved with analyses that use local data; i.e., farm/vineyard data. Thus, the challenge lies in exploiting farm data to enable grape growers to understand their own terroir and consequently adapt their practices to the local conditions. In such a context, this article proposes an analytical process to site-specifically study climate influence on grapevine physiology by focusing on time series of the weather data often contained in farm data sets. This article focuses on temperature and precipitation influence on yield in the form of a case study. The analytical process includes the Extended Growing Degree Days (eGDD) and the Bayesian functional Linear regression with Sparse Steps functions (BLiSS) methods in order to detect site-specific periods of strong climate influence on grapevine yield. It uses data from three commercial vineyards situated in the Bordeaux region (France), California (USA) and Israel. In general, the periods of climate influence on grapevine yield detected for the three vineyards identified the same stages of yield development, which have already been studied in the scientific literature. However, some vineyard differences were observed, including: i) different periods of influence associated with a given stage of yield development between the vineyards, ii) different influential weather variables between the three vineyards for a given period, and iii) differing duration of the period of influence associated with a given stage of yield development between the vineyards. These results show the potential of the proposed analytical process for analysing the time series of farm weather data in order to extract site-specific climate indicators of grapevine yield.
Between tough voyages and empowering tourism: Can Muslim Bugis seafarers tackle the maritime-sector crises in Indonesia?
Authors: Rozaki Abdur
Published: June 2022

This paper explores the shift in commercial sailing by the Muslim coastal community of the ethnic Bugis—from their past focus on inter-island and international commerce to maritime tourism that is limited to the Eastern Indonesian region for domestic and foreign tourists. Using historical and phenomenological approaches, this paper explains a series of arduous crises to show the dignity and prosperity of the great maritime tradition among commercial seafarers, who, during the Islamic empire from the 15th to 17th century, experienced glory for being able to control and manage maritime commerce. Ever since the presence and success of the Europeans, especially the Dutch, in controlling Nusantara (the Indonesian archipelago), the glory of Muslim seafarers’ trade voyages has dwindled and narrowed, both in terms of the number of ships, types, and tonnage of cargo, as well as their cruising range. Although the Indonesian government has not systematically and comprehensively formulated policies to restore the glory in the maritime sector so far, tourism development policies have been welcomed by the Muslim Bugis seafarers as a new opportunity to empower the family economy.
Use of Procalcitonin as a Biomarker for Sepsis in Pediatric Burns
Authors: Oncul Ummuhan , Dalgıç Nazan , Demir Mesut , Karadeniz Pınar , Karadağ Çetin Ali
Published: June 2022

Introduction: Infection and sepsis continue to be the leading cause of morbidity and death in burn injuries. Diagnosing sepsis in burns is challenging as signs and symptoms of sepsis are not specific and overlap with those related to the burn injury. While use of procalcitonin (PCT) as a biomarker is recommended for diagnosing sepsis in burns, evidence for children with burns is scarce. In this study, we aimed to investigate the role of PCT for distinguishing sepsis in pediatric burns.Methods: A prospective observational study was conducted in a single pediatric burn unit. Children hospitalized with burns ≤30% of total body surface area were included while patients with chemical burn, inhalation injury or concomitant chronic disease were excluded. Patients were classified into three groups for sepsis, systemic inflammatory response syndrome (SIRS) or controls using the American Burn Association (ABA) criteria. Predictive role of C-reactive protein (CRP) and PCT was investigated for distinguishing sepsis.Results: Seventy-two patients were included in the study. Median total body surface area (TBSA) size was 12% (2.0-28.5%) and median abbreviated burn severity index (ABSI) score was 3 (2-7). Median length of burn unit stay was 9.5 days (1-59 days). Sepsis was diagnosed in 11 patients (15.2%) and SIRS was present in 23 patients (40.0%), whereas 38 patients (52.8%) had neither SIRS nor sepsis (control group). Receiver operating characteristic analysis revealed that CRP and PCT levels distinguished sepsis patients from non-sepsis patients while PCT had a higher positive predictive value (64.3% vs 47.6%). Optimal cut-off values of CRP and PCT for distinguishing sepsis were 66.75 mg/L and 2.54 ng/mL. Conclusions: PCT levels could distinguish sepsis in children with burn injuries, performing better than CRP levels. Confirmatory studies are needed to evaluate the development of sepsis and role of PCT for diagnosing sepsis in pediatric burn patients.
Valuation of vulnerable European and barrier options under uncertain stock model driven by Liu process
Authors: Mehrdoust Farshid , Noorani Idin
Published: June 2022

Stock markets around the world are growing rapidly and vulnerability created by default risk of option holders has become a serious issue. In such circumstances, this paper suggests the pricing of vulnerable European and barrier options when the underlying asset follows the uncertain stock model. According to the uncertainty theory, we present closed-form analytic formulas of these options prices and use the residuals method to estimate the uncertain stock model parameters. Ultimately, based on the estimated parameters, we evaluate the effect of the vulnerable option parameters on its price.
Effective waste water management in colouration of polyester using Bio-shell microcapsules
Authors: Mishra Leena , Basu Gautam
Published: June 2022

The present work aimed at efficient utilization of resources viz., water, dyes and chemicals (without using any supportive chemical) for colouration of polyester. Disperse dye microcapsules were prepared using the method of complex coacervation. Bio-shell coated microcapsules of disperse dyes were analyzed for their resource efficient auxiliary chemicals free colouration on polyester (PET) over conventionally dyed one. The remnant liquor recovered from colouration of polyester was recycled for subsequent four colouration cycles (without treatment) showing acceptable shade difference. The remnant liquor obtained from fourth colouration cycles treated with basic primary water treatments and was found to be translucent, neutral in pH and low effluent load (TDS > 231 ppm, BOD > 114 mg/l, and COD > 469 mg/l). The solids recovered from bath were analyzed and found to be nontoxic (LD50,> 8000) as well. Cost involved in microencapsulated colouration (USD $ 6.48) is lower than that of conventional process of colouration (USD $ 8.40). Thus, microencapsulated colouration is easily adoptable in existing process line of polyester colouration, which leads to small liquid discharge of low.
A systematic review of skin ageing genes reveals a pleiotropic landscape where skin colour genes and chromosomal band 16q24.3 genes may drive skin ageing
Authors: NG Jun Yan , CHEW Fook Tim
Published: June 2022

Skin ageing is the result of intrinsic genetic and extrinsic lifestyle factors. However, there is no consensus on skin ageing phenotypes and ways to quantify them. In this systematic review, we first carefully identified 56 skin ageing phenotypes from multiple literature sources and sought the best photo-numeric grading scales to evaluate them. Next, we conducted a systematic review on all 44 Genome-wide Association Studies (GWAS) on skin ageing published to date and identified genetic risk factors (2,349 SNPs and 366 genes) associated with skin ageing. We identified 19 promising SNPs found to be significantly (p-Value < 1E-05) associated with skin ageing phenotypes in two or more independent studies. Here we show, using enrichment analyses strategies and gene expression data, that 1) pleiotropy is a recurring theme among skin ageing genes, 2) SNPs associated with skin ageing phenotypes are mostly located in a small handful of 44 pleiotropic and hub genes (mostly on the chromosome band 16q24.3) and 32 skin colour genes, 3) genes traditionally identified to contribute to skin colour have more than just skin pigmentation roles, and 4) further progress towards understand the development of skin pigmentation requires understanding the contributions of genes on the chromosomal band 16q24.3. We anticipate our systematic review to serve as a hub to locate primary literature sources pertaining to the genetics of skin ageing and to be a starting point for more sophisticated work examining pleiotropic genes, hub genes, and skin ageing phenotypes.
Ecological, flexible and transparent cellulose-based substrates without post-production treatment for organic electronic devices
Authors: Carneiro Martina , Neves Matheus F. F. das , de Muniz Graciela I. B. , Filho Marco A. S. C. , Oliveira Camilla K. , Roman Lucimara S.
Published: June 2022

In the past few decades, technological advances have aroused the interest of industries and consumers for flexible electronic devices. However, the substrates currently used, such as glass and polyethylene terephthalate (PET), present problems regarding their performance and destination, since the first is difficult to handle and the second comes from non-renewable sources. Common properties required in substrates to provide their use in organic electronics are flexibility, stability and sufficient transparency. Therefore, as a sustainable and efficient alternative, the present study aimed to develop a totally cellulose-based substrate, a natural abundant polymer that presents thermal stability, mechanical strength, recyclability and is biodegradable. It was produced different substrates using microfibrils from Eucalyptus sp. A pure microfiber substrate weighing 25 g m-² was obtained by the vacuum filtration method and paper-forming machine. The other four substrates were obtained by the casting method containing cellulose acetate matrix and freeze-dried microfibrils reinforcement at different concentrations. In addition, a substrate containing 1.0 % of the suspended microfibrils as reinforcement in the cellulose acetate matrix was produced. A conductive thin film of Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) was deposited by air-brush technique as an electrode to evaluate the electrical performance of the substrates. The obtained films were characterized by their optical, thermal and morphological properties, showing a great potential to be used as substrate in organic electronic devices.
A comprehensive intervention package including an egg- and milk-based snack improves the linear growth and dietary diversity of children under two years children in rural Bangladesh: A community-based cluster randomized controlled trial
Authors: Ara Gulshan , Sanin Kazi Istiaque , Khanam Mansura , Sarker Shafiqul Alam , Tofail Fahmida , Nahar Baitun , Chowdhury Imran Ahmed , Boitchi Anika Bushra , Gibson Sarah , Afsana Kaosar , Askari Sufia , Ahmed Tahmeed
Published: June 2022

Approximately one-third of children under-five in developing countries are stunted and many are micronutrient-deficient. We aimed to compare the effect of an intervention package including egg and milk-based snacks on linear growth and dietary diversity of children of 6‒12 months in rural Bangladesh. It was a community-based cluster randomized controlled longitudinal trial where 412 mother-infant dyads were allocated to receive either regular government health communication only (control; n = 206) or food vouchers (including eggs, semolina, milk, sugar, and oil) monthly to prepare egg and milk-based snacks, along with multiple micronutrient powder (MNP), child feeding and handwashing counseling for one year (treatment; n = 206). The difference in length gain and dietary diversity of the children was respectively the primary and secondary outcomes of the study. The intervention was tested using a generalized linear regression model. At baseline, the mean weight and length of the children did not significantly differ between groups. Around ninety percent of the children in both groups were breastfed. At endpoint, the mean length of children was (83.52 and 80.89 cm; difference: 2.62, p<0.001); LAZ score (Cof: 0.38, CI: 0.24, 0.51, p<0.001); rate of stunting (IRR: 0.39, CI: 0.22, 0.67, p<0.001); and dietary diversity were significantly better in the treatment group. This comprehensive intervention package improved the growth and dietary diversity of children in ultra-poor Bangladeshi households; scaling up this intervention within resource-poor settings should be considered. Trial registration: It was registered retrospectively at ClinicalTrials.gov as NCT03641001, 21/8/2018
Central Venous Pressure Estimation with Force-coupled Ultrasound of the Internal Jugular Vein
Authors: Jaffe Alex , Goryachev Ivan , Sodini Charles , Anthony Brian
Published: June 2022

We estimate central venous pressure (CVP) with force-coupled ultrasound imaging of the internal jugular vein (IJV). We acquire ultrasound images while measuring force applied over the IJV by the ultrasound probe imaging surface. We record collapse force, the force required to completely occlude the vein, in 27 healthy subjects. We find supine collapse force and jugular venous pulsation height (JVP), the clinical noninvasive standard, have a linear correlation coefficient of r2 = 0.89 and an average absolute difference of 0.23 mmHg when estimating CVP. We perturb our estimate negatively by tilting 16 degrees above supine and observe decreases in collapse force for every subject which are predictable from our CVP estimates. We perturb venous pressure positively to values experienced in decompensated heart failure by having subjects perform the Valsalva maneuver while the IJV is being collapsed and observe an increase in collapse force for every subject. Finally, we derive a CVP waveform with an inverse three-dimensional finite element optimization that uses supine collapse force and segmented force-coupled ultrasound data at approximately constant force.
Gene Expression and Radiation Response of Two Distinct Neuroblastoma Cell Lines
Authors: Ritner Carissa , Popovic Jelena , Abouzeid Aushra , Li Ya , Paunesku Tatjana , Papineni Rao , Woloschak Gale
Published: June 2022

Background: External beam radiation is infrequently used for treatment of pediatric cancer such as neuroblastoma, typically reserved for palliative care in patients with aggressive metastatic disease who fail to respond to alternative treatments. Understanding effects of radiation on neuroblastoma cells could improve efficacy of this final means of therapy to decrease tumor burden and stabilize the disease. Methods: In this study, clonogenic assays were used to establish radiation responses for SK-N-AS and SK-N-DZ cell lines; cells were then irradiated at doses that cause 90% cell killing based on clonogenic assay and their RNA isolated and subjected to microarray analysis. In addition, cells were transfected with pre-miRNA constructs that led to overexpression of microRNAs miR-34a and miR-1228 in combination with radiation exposure to determine possible miRNA regulation of radiation response. Results: Statistically significant differences were detected for expression of several thousands of genes when the two cell lines were compared with each other. In contrast, radiation led only to minor gene expression differences of less than two-fold between irradiated and non-irradiated cultures in both cell lines. Overexpression of miR-34a and miR-1228 in either cell line did not change this outcome. Conclusion: Neuroblastoma cell lines SK-N-AS and SK-N-DZ are phenotypically diverse and gene expression differences between them are extensive. However, the regulation of gene expression in both of these cell lines is in a stable equilibrium even when exposed to stressors such as radiation.
Metal nanoparticles/carbon nanosheets-derived from covalent organic frameworks for electrochemical sensing furazolidone, dopamine and uric acid
Authors: Xiong Jianhui , Yang Yuxi , Wang Linyu , Chen Shouhui , Du Yan , Song Yonghai
Published: June 2022

Covalent-organic frameworks (COFs) are a kind of porous crystalline materials that are boned together by covalent bonds. Abundant functional sites and adjustable pore structure make COFs become potential precursors to prepare metal nanoparticles (MNP)/heteroatoms-doped carbon nanosheets with well-ordered micropores (CN) nanozymes for electrochemical sensors. In this work, a new two-dimensional COFTD with double chelating sites were prepared by using 1,3,5-tris(4- aminophenyl)benzene and 2,6-dihydroxynaphthalene-1,5-diformaldehyde. The COFTD was used as a precursor to load Cu2+, Fe3+, Co2+ and Ni2+. By carbonizing, the COFTD was transformed into CN and metal ions were reduced into 5–10 nm MNP loaded on CN uniformly (CuNPs/CN, FeNPs/CN, NiNPs/CN and CoNPs/CN). These MNP/CN nanocomposite materials were used for electrochemical detection of both dopamine and uric acid at the same time. The electrochemical sensors based on MNPs/CN nanozymes have good detection performance. Finally, CuNPs/CN was also used to construct a furazolidone sensor. The furazolidone electrochemical sensor has excellent performance with a linear range of 61.5 nM-200 µΜ and a detection limit of 20.1 nM. At the same time, it also has good reproducibility and repeatability.
Differentially expression analyses of cultivated and wild species of grape and peach
Authors: Huang Weijian , Li Meng , Zhang Huangwei , Wu Juyou , Zhang Shaoling
Published: June 2022

Through agronomic traits and sequencing data, the cultivated and wild varieties of grapes and peaches were analyzed and compared in terms of fruit size, fruit flavor, fruit resistance, and fruit color. Cultivated grapes and peaches have advantages in fruit size, soluble sugar content, sugar and acid ratio, etc. Wild grapes and peaches have utility value in resistance. The results showed that there were 878 and 301 differentially expressed genes in cultivated and wild grapes and peaches in the three growth stages, respectively based on the next-generation sequencing study. Ten and twelve genes related to the differences between cultivated and wild grapes and peaches were found respectively. Among them, 3 genes exist in both cultivated and wild grapes and peaches, including: chalcone synthase (CHS), glutathione S-transferase (GST) and malate dehydrogenase (MDH1) genes.
Early Intelligent Fault Diagnosis of Rotating Machinery Based on IWOA-VMD and DMKELM
Authors: Jin Zhenzhen , He Deqiang , Lao Zhenpeng , Wei Zexian , Yin Xianhui , Yang Weifeng
Published: June 2022

The effect of early fault vibration signals from rotating machinery is weak and easily drowned out by intensive noise. Thus, it is still a great challenge to perform early fault diagnosis. An intelligent early fault diagnosis method for rotating machines is proposed based on Variational Mode Decomposition (VMD) parameter optimization and Deep Multi-Kernel Extreme Learning Machine (DMKELM). First, the iterative chaotic mapping, nonlinear convergence factor and inertia weight are introduced into the whale optimization algorithm (WOA). Then, an improved WOA (IWOA) is presented and utilized to optimize VMD parameters. The optimized VMD (OVMD) combined with the sampling entropy is used to denoise and reconstruct the signals. Finally, the mish function is served as the activation function. Meanwhile, the radial basis kernel function (RBF) and polynomial kernel (PK) are introduced to construct the mixed kernel function. The mixed kernel assignment is applied to replace the random assignment, and the DMKELM is presented to enhance the classification performance and generalization capability of the model, and DMKELM is used for early intelligent fault diagnosis. Two experiments on bearings and gears demonstrated that the fault diagnosis accuracy is 99% and 98.5%, respectively, and the fault diagnosis accuracy is high. It shows that this method has great superiority in early fault diagnosis of rotating machinery.
A Novel Approach on Cognitive Radio Sensor Networks for Efficient Data Transmission
Authors: M Sudha , Kandasamy Ravisankar , Kumar S.Satheesh
Published: June 2022

Data Transmission plays an important role in the digital world. This transfer occurs via point-to-point data streams or channels. These channels may previously have been in the form of copper wires but are now much more likely to be part of a wireless network. In here, We are using Cognitive Radio(CR) a concept on Wireless Sensor Networks(WSN) which is being used as an intelligent wireless Communication Technology having unique Capabilities of monitoring spectrum bands and detecting available channels to enable the usage of statically allocated spectrum. Furthermore, by dynamically adjusting its operating parameters, it can utilize available channels and to attack the upcoming spectrum crunch issue. Cognitive Radios can be used to find unused licensed spectrum and it can be utilized by secondary users without causing any interference to licensed users. Some of the existing techniques used in Cognitive Radio include spectrum sensing using energy detection, spectrum database, and pilot channel. In here we are using Momentum Search Algorithm technique is functioning on momentum conservation law and kinetic energy conservation law. The data to be transferred will be dynamically split and they will be scheduled for transferring. And the selection of channel will change accordingly for higher efficiency channel selection to transfer the data without loss and the transmission of data packets having higher size will have higher efficiency and the data packet consists of 8-bit for the address of data packets. It is used to Bring down the errors and damages in the data packets. Using Momentum Search Algorithm rule the user can utilize the same degree of interference as Primary users(PU) and to transfer Higher size of data packets on higher efficiency. This proposal shows the way out in achieving the first-rate performance of Data Transmission using Cognitive Radio Network based on Momentum Search Algorithm.
CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer’s disease
Authors: Qiang Qiang , Skudder-Hill Loren , Toyota Tomoko , Wei Wenshi , Adachi Hiroaki
Published: June 2022

Objective：To test whether cerebrospinal fluid (CSF) growth-associated protein 43 (GAP-43) concentration is elevated in Alzheimer’s Disease (AD) dementia and its associations with other hallmarks of AD.Methods: We examined the CSF GAP-43 measurements of 787 participants (245 cognitively normal (CN), 415 individuals with mild cognitive impairment (MCI) and 127 individuals with AD dementia from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. Associations were investigated between CSF GAP-43 and clinical diagnosis, Aβ/tau/neurodegeneration (AT(N)) status, CSF and blood biomarkers of AD, cognitive measurements and brain neuroimaging findings. Results: CSF GAP-43 levels were increased in patients with AD dementia (mean, 6331.05 pg/ml) compared with the CN (mean, 5001.05 pg/ml) and MCI (mean, 5118.8 pg/ml) (P < 0.001) groups. CSF GAP-43 correlated with CSF phosphorylated tau 181(p-tau) (r = 0.768, P < 0.001), and had high diagnostic accuracy in differentiating tau positive status vs. tau negative status (area under the receiver operating characteristic curve, 0.8606). CSF GAP-43 was particularly elevated among individuals with tau positive status. High CSF GAP-43 was associated with longitudinal deterioration of cognitive scores and brain neuroimaging findings. Conclusions: CSF GAP-43 was associated with a clinical diagnosis of AD dementia and with an individual’s tau status, cognitive measurements and findings from neuroimaging. This study implies that CSF GAP-43 as a biomarker of synaptic dysfunction could predict the disease progression of AD patients.
High-intensity interval training ameliorate diabetes-induced disturbances in Alzheimer's-related factors in the hippocampus through adiponectin signaling
Authors: khoramipour kayvan , Bejeshk Mohammad Abbas , Rajizadeh Mohammad Amin , Najafipour Hamid , Dehghan Padideh
Published: June 2022

Objectives: Alzheimer’s disease (AD) is closely related to type 2 diabetes (T2D). This study investigated the impact of High-intensity interval training (HIIT) on diabetes-induced disturbances in AD-related factors (including AMP-activated protein kinase (AMPK), Glycogen synthase kinase-3β (GSK3β), and Tau protein) in the hippocampus, with the main focus on adiponectin signaling. Methods: 40 male Wistar rats at the age of 8 weekd were randomly assigned to four groups: control (Con), type 2 diabetes (T2D), HIIT (Ex), and type 2 diabetes + HIIT (T2D+Ex). T2D was induced by high-fat diet plus a single dose of Streptozotocin (STZ). Rats in Ex and T2D+Ex groups performed eight weeks of HIIT (running at 80-95% of Vmax, 4-10 intervals). Insulin and adiponectin levels in serum and hippocampus were measured along with hippocampal expression of insulin and adiponectin receptors, AMPK, GSK3β, and Tau. Homeostasis model assessment for Insulin Resistance (HOMA-IR), Homeostasis model assessment for Insulin Resistance Beta (HOMA-β), and quantitative insulin sensitivity check index (QUICKI) were calculated to assess insulin resistance and sensitivity. Results: T2D decreased insulin and adiponectin levels in serum and hippocampus as well as the hippocampal levels of insulin and adiponectin receptors and AMKP but increased GSK3β and Tau in the hippocampus. HIIT reversed diabetes-induced impairments and consequently decreased Tau accumulation in the hippocampus of diabetic rats. HOMA-IR, HOMA-β, and QUICKI were improved in Ex and T2D+Ex groups. Conclusion: Overall, our results confirmed that T2D has undesirable effects on the levels of some Alzheimer's-related factors in the hippocampus and HIIT could ameliorate these impairments in the hippocampus.
Performance analysis of all optical based quantum internet circuits
Authors: Sharma Amit Kumar , Sharma Ritu , Sharma Shishir Kumar
Published: June 2022

A Quantum dot implanted within double-sided optical microcavity is explained and established as a critical component for all optical-based quantum internets. Due to the duality as the photonic quantum transistor and gate, the QD cavity system presents a sturdy base for the future photonic quantum network. With the help of the analytical investigation and review presented in this paper, a quantum dot cavity unit can be developed for implementing deterministic quantum gates and transistors. The maximum fidelity observed for quantum diode, router, and storage is 95.24%, 62.06%, and 90.42% without considering a noisy environment, respectively, and 62.12%, 60.36%, and 43.66% under a noisy environment, respectively. Fidelity is also calculated with varying coupling conditions (strong and weak coupling), and optimized cavity parameters are calculated. The paper also reports the work done by various researchers till date.
Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS
Authors: Belzen Ianthe A.E.M. van , Cai Casey , Tuil Marc van , Badloe Shashi , Strengman Eric , Janse Alex , Verwiel Eugène T. , Leest Douwe F.M. van der , Kester Lennart , Molenaar Jan J. , Meijerink Jules , Drost Jarno , Peng Weng Chuan , Kerstens Hinri H.D. , Tops Bastiaan B.J. , Holstege Frank C.P. , Kemmeren Patrick , Hehir-Kwa Jayne
Published: June 2022

BackgroundGene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection. Recent developments show RNA sequencing (RNA-seq) is promising for genome-wide detection of fusion products but hindered by many false positives that require extensive manual curation and impede discovery of pathogenic fusions. MethodsWe developed Fusion-sq to overcome existing disadvantages of detecting gene fusions. Fusion-sq integrates and “fuses” evidence from RNA-seq and whole genome sequencing (WGS) using intron-exon gene structure to identify tumor-specific protein coding gene fusions. Fusion-sq was then applied to the data generated from a pediatric pan-cancer cohort of 129 patients by WGS and RNA sequencing. ResultsIn a pediatric pan-cancer cohort of 129 patients, we identified 155 high confidence tumor-specific gene fusions and their underlying structural variants (SVs). This includes all clinically relevant fusions known to be present in this cohort (30 patients). Fusion-sq distinguishes healthy-occurring from tumor-specific fusions and resolves fusions in amplified regions and copy number unstable genomes. A high gene fusion burden is associated with copy number instability. We identified 27 potentially pathogenic fusions involving oncogenes or tumor-suppressor genes characterized by underlying SVs, in some cases leading to expression changes indicative of activating or disruptive effects. ConclusionsOur results indicate how clinically relevant and potentially pathogenic gene fusions can be identified and their functional effects investigated by combining WGS and RNA-seq. Integrating RNA fusion predictions with underlying SVs advances fusion detection beyond extensive manual filtering. Taken together, we developed a method for identifying candidate gene fusions that is suitable for precision oncology applications. Our method provides multi-omics evidence for assessing the pathogenicity of tumor-specific gene fusions for future clinical decision making.
Effect of silver variation on Ag-TiO2 nanocomposite synthesized by sol-gel
Authors: Mohammed Ban K. , zamel rafid s. , Khlaief Jabbar H.
Published: June 2022

The simple sol-gel technique was utilized to prepare pure nanocomposite TiO2 and Ag\TiO2. The structure, surface as well as optic features of the pure nanocomposite TiO2 and Ag\TiO2 were verified by adding different concentrations of Ag to TiO2 at (0, 2, 4, and 6 mol%), respectively and annealed at temperatures of 450oC for 2h. The XRD diffraction patterns show anatase stage within pure TiO2, while in state of Ag\TiO2 nanocomposite there is a stage for Ag cubic corresponding to high concentrations of Ag content. The optical properties reveal the absorption band induced by surface plasmon resonance (SPR) in the visible area, which is the hallmark of Ag Nanoparticles. The FTIR analysis confirms the formation functional groups due to the interaction of TiO2 with Ag species. The surface morphology of pure TiO2 and Ag\TiO2 nanocomposite powder was distinguished through FESEM (field emitting scan electron microscopy). In state of higher Ag content, the Ag\TiO2 nanocomposite is formed with less aggregation and smaller size compared with pure TiO2.
Household disinfection practices by women living in Egypt during the 2020 COVID-19 lockdown and the association of information sources and suspected bleach toxicity
Authors: Farid Maha , Talaat Rania , Pacino Valerie , Tak Hyo Jung , ElRayes Wael
Published: June 2022

The spread of contradictory health information was a hallmark of the early COVID-19 pandemic. Because of a limited understanding of the disease, its mode of transmission, and its pathogenicity, the public turned to easily accessible and familiar sources of information. Some of these sources included wrong or incomplete information that could increase health risks and incidents of toxicity due to improper information about the usage of disinfectants. In this study, 452 adult women living in Egypt were surveyed through a self-administered online questionnaire in Arabic. The questionnaire collected data about their household cleaning and disinfection practices to prevent the spread of the SARS-CoV-2 virus and protect their families during the lockdown that started in Egypt in March 2020. The study found that 88.1 percent of participants reported increased use of disinfectants during the lockdown. Women who chose social media as their primary source of information to learn about disinfection practices reported an increased frequency of respiratory symptoms associated with bleach toxicity, followed by women who depended on relatives and friends as the primary source of information. This study showed that social media is a powerful tool that can act as a primary source for individuals seeking medical information. Restrictions and regulations may help limit the harms caused by the misinformation and disinformation spread by these popular modes of communication, particularly in times of uncertainty and upheaval.