bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Posisi Pemangkasan Daun Jagung Dalam Sistem Tumpang Sari Terhadap Pertumbuhan dan Hasil Kedelai
Authors: Mapegau Mapegau , Hayati Islah , Nizori Addion , Lestari Ardiyaningsih Puji , Marlina Marlina
Published: December 2022

This study aims to determine the effect of corn leaf pruning on soybean growth and yield in an intercropping system. This research was carried out on farmers' land in Simpang Village, Berbak District, Tanjung Jabung Timur Regency from July - October 2020. This research was carried out using a Randomized Block Design (RBD) with 5 replications. Pruning treatments based on the position of the leaves on the stem were : without pruning (control/p0), pruning 3 leaves at a position near the soil surface (p1), pruning 3 leaves at a position below the cob (p2), and pruning 3 leaves at a position above the cob (p3). The variables observed included soybean plant height (cm), number of pods per plant, number of filled pods per plant, weight of 100 dry seeds (g), and soybean dry seed yield. The results showed that the highest soybean plant height was obtained without pruning and pruning 3 corn leaves near the soil surface, but produced the lowest number of pods per plant, number of filled pods, and the lowest soybean dry seed yield. The number of pods per plant, the number of containing per plant, and the highest soybean dry seed yield were obtained at pruning of 3 leaves under the cob and 3 leaves of corn above the cob. In corn, the highest yield was obtained by pruning 3 leaves below the cob and 3 leaves above the cob. The diversity of soybean dry seed yields in this study was determined jointly by the diversity of the number of pods per plant, the number of filled pods per plant, and the weight of 100 dry seeds. Partially, only the number of pods contained per plant and the weight of 100 dry seeds significantly played a role in determining the amount of dry soybean yield, while the number of pods per plant had no significant role in determining the diversity of dry seed yields. Land use with corn and soybean intercropping system can increase land productivity so that it is more efficient with LER value > 1 in all positions of corn leaf pruning. Keywords: pruning, intercropping corn, soybean
THE INFLUENCE OF SHARIA HOTEL INDICATORS TOWARDS ITS COMPETITIVE ADVANTAGE AND GUEST INTENTION TO STAY: AN APPRAISAL
Authors: Hadiasali Abisag Elladora , Wijaya Serli , Widjaja Deborah C. , Jaolis Ferry
Published: December 2022

Indonesia, the country with the largest Muslim population in the world, showed an increase in the development of sharia hotels that apply sharia laws and regulations as their operating system. This study aims to explore both hotel executives' and consumers’ perceptions of sharia hotels and the impact on creating the hotel’s competitive advantage, which will affect guest intention to stay. In-depth interviews were completed with hotel executives of sharia and non-sharia hotels as one group and with sharia and non-sharia hotels guests as the other group. In-depth interviews and thick narratives nuance the research processes and inductive data reduction. The interview data were processed using thematic analysis. Two major themes were revealed from the interviews: governments are relatively slow in certifying standard regulations for sharia hotels and there is still a discrepancy concerning the perceptions among hotel executives and customers about what constitutes a sharia hotel. A clear and comprehensive definition of the sharia concept will make public perceptions, both in terms of hotel executives and hotel consumers, stand on the same ground. A conceptual model has been proposed based on the study findings, expected to enrich the body of literature regarding sharia hotel indicators that need to be taken into account by management to build its competitive advantages. Further research employing a quantitative approach is suggested to validate the underlying factors in the model that influence consumers' intentions to stay at sharia hotels.
Etika Periklanan, Studi Kasus pada Iklan Grab Bike
Authors: Hardi Nugraha Tunggele Hardi
Published: December 2022

Advertising is a medium used to offer products to consumers. The great benefits of advertising in attracting consumers make companies compete to create creative advertisements. However, it is possible that the advertisements serve to violate ethics. This research analyzes the ethical values in the #SelectAman advertisement from the Grab Bike company with a critical approach. The perspective used is the ethical dimension by Tanya Robertson, with descriptive qualitative research methods. The selection of the descriptive qualitative method is based on the object of the material being studied and the level of adaptability of this method. The results of the study show that the #PilihAman ad from Grab Bike is a negative and unethical advertisement because it gives a bad picture of competing products
Decision Making Empowerment Among Women With And Without Microcredit Coverage
Authors: Ferdousi Nigar , Islam Md Ziaul , Sultana Sadia , Jahan Nur Wa Bushra
Published: December 2022

Background: Women of Bangladesh, especially rural women experience adverse situations in terms of socioeconomic inequality and gender disparity. This study compared the decision making empowerment among women with and with microcredit coverage.
Methods: The study design was a cross sectional study in two sample situation. Total 258 women, 129 with microcredit coverage and 129 without microcredit, was selected by convenience sampling technique from Pakdy and Thantoly of Madaripur district in Bangladesh. Data were collected by face to face interview with the help of a semistructured questionnaire. Data were analyzed by SPSS software. Quality control and ethical issues were maintained strictly.
Results: The study revealed that mean (±SD) age of women with microcredit coverage was 30.27(±9.62) years and women without microcredit coverage was 30.78(±8.98) years. Mean (±SD) score of decision making empowerment was significantly higher among women with microcredit (34.02±3.92) than without microcredit (17.89±5.20) (p<0.01). Mean (±SD) score of household related decision making empowerment among women with microcredit 14.22 (±1.96) was significantly higher (p<0.01). Mean (±SD) score of physical movement related decision making empowerment among women with microcredit (9.39±1.57) was significantly higher (p<0.01). Mean (±SD) score of economic decision making empowerment was significantly higher among women with microcredit coverage (10.50±1.324) (p<0.01). There were significant positive relationships between age of women with microcredit coverage and decision making empowerment (r=0.133). There were significant positive relationships between age (r=0.375) and monthly family income (r=0.308) of women without microcredit coverage and decision making empowerment.
Conclusion: This study revealed that rural women had enhanced their decision making empowerment by participating in microcredit programmes.
JOPSOM 2021; 40(2):1-8
Practice of Nurses on Patient Record Management In Tertiary Level Hospitals
Authors: Corraya Elezabeth , Akhtar Khursheda , Azizi Shajeda
Published: December 2022

Background: Patient record prescribed further state of health of the patient and determines the diagnosis of diseases by exerting the history. The study was conducted to assess the practice of patient record management among nurses in a selected government hospital, Dhaka, Bangladesh.
Methods: A descriptive type of cross-sectional study was done among 214 respondents following convenient methods of sampling from Shaheed Suhrawardy Medical College Hospital (ShSMCH), Dhaka, Bangladesh from January to December 2020. Data were collected through face-to-face interview by using a pretested semi-structured questionnaire.
Results: The study revealed that about 27% of the respondents were belonging to the 26-30 age groups and the mean ± SD of age was 35.16 ± 6.93. Most of the respondents 48% were diploma in nursing. Out of 214 respondents, the pattern of nursing documentation was always filled up by about 97%, documentation practice was taken manually by 55%, management of missing files was done by 33% of respondents, and confidentiality record kept access for authorized ones was mentioned by 58%. Keeping patient records after death was made by 34.2% of respondents and preservation of medico-legal files was stored on papers narrated by 90% of the respondents. The majority of the respondents 73.4% mentioned inadequate working knowledge as a barrier in medical history training.
Conclusion: Practice of Nurses on patient record management may help the authority to identify any error in the patient care, self-evaluation, and assure the quality of care. The study has an immense value if it’s possible to develop the electronic data record-keeping system in every government hospital.
JOPSOM 2021; 40(2): 38-43
STRATEGI PEMASARAN DALAM MEMPERTAHANKAN EKSISTENSI BISNIS OLEH-OLEH KHAS LOMBOK DITENGAH PANDEMI COVID 19 ( Studi Kasus Pada Toko Oleh-Oleh Sasak Maiq)
Authors: Septika Baiq Herdina , Krisnahadi Tama , Aryani Menik
Published: December 2022

Abstract: This study aims to determine the marketing strategy implemented by Sasak Maiq SMEs during the Covid 19 pandemic, especially related to the marketing mix. This study uses a qualitative method, namely a case study that produces descriptive data set out in words. Sources of data in this study using purposive sampling and data collection techniques in this study the authors made a direct visit to UKM Sasak Maiq to conduct personal interviews with the main director, employees and several consumers. The strategy carried out by Sasak Maiq to be able to survive in the midst of the Covid 19 Pandemic is the Bauran 4P (Product, Promotion, Price and Place) mix. Based on the research that has been done, the researcher concludes that there are several strategies used related to the Marketing Mix, namely the product strategy, namely food innovation, the promotion strategy, namely participating in major events related to MSME product exhibitions and sales through social media, the price strategy, namely price discounts, and the marketing strategy. place, namely flexibility in product delivery. Even though there are financial constraints, Sasak Maiq can still find solutions and alternatives, namely by managing finances, namely by product innovation, maximizing social media and maximizing delivery services. Keywords: Marketing Strategy, Marketing MixAbstrak: Penelitian ini bertujuan untuk mengetahui strategi pemasaran yang diterapkan UKM Sasak Maiq selama pandemi Covid 19 khususnya  terkait dengan bauran pemasaran (Marketing Mix). Penelitian ini menggunakan metode kualitatif, yaitu studi kasus yang menghasilkan data- data deskriptif yang dituangkan dalam kata-kata. Sumber data pada penelitian ini menggunakan teknik Purposive Sampling dan teknik pengumpulan data pada penelitian ini penulis melakukan kunjungan langsung ke UKM Sasak Maiq untuk melakukan wawancara pribadi dengan Direktur utama, karyawan-karyawan dan beberapa konsumen. Strategi yang dilakukan oleh Sasak Maiq untuk bisa tetap bertahan ditengah Pandemi Covid 19 yaitu Bauran 4P (Product, Promotion, Price and Place).  Berdasarkan penelitian yang sudah dilakukan maka peneliti menyimpulkaan ada beberapa strategi yang digunakan terkait dengan Marketing Mix yaitu strategi product yaitu inovasi makanan, strategi promotion yaitu mengikuti event-event besar terkait pameran produk UMKM dan penjualan melalui sosial media, strategi price yaitu potongan harga, dan strategi place yaitu fleksibilitas dalam pengiriman produk. Meskipun ada kendala keuangan tetapi Sasak Maiq masih bisa menemukan solusi dan alternatifnya yaitu dengan mengelola keuangan  yaitu  dengan inovasi produk, memaksimalkan media sosial dan memaksimalkan layanan antar atau delivery.  Kata Kunci : Strategi Pemasaran, Bauran Pemasaran
ANALISIS KINERJA GURU MENGGUNAKAN TEKNOLOGI INFORMASI DALAM PEMBELAJARAN DI SEKOLAH DASAR 44 MATARAM
Authors: Anam M Chairul
Published: December 2022

Abstrak: Penelitian ini bertujuan untuk mendeskripsikan keterampilan guru menggunakan teknologi informasi dalam pembelajaran di sekolah dasar. Metode penelitian yang digunakan adalah metode penelitian deskriptif kualitatif dengan langkah-langkah pendahuluan, lapangan dan analisis data. Sumber data seluruhnya adalah 8 orang di SDN 44 Mataram, 3 guru laki-laki dan 5 guru perempuan. Teknik pengumpulan data yang digunakan adalah observasi. Lembar analisis dan lembar observasi kinerja guru dijadikan sebagai alat penelitian. Teknik analisis data dilakukan dengan menggunakan teknik analisis data kualitatif. Hasil penelitian menunjukkan bahwa keterampilan guru untuk mengintegrasikan laptop, internet dan Infocus di pendidikan dasar berada pada tingkat menengah. Sebagian besar guru sudah memahami penggunaan teknologi informasi dalam pembelajaran dan dapat merancang presentasi dan menampilkan materi pembelajaran dengan mudah, tetapi mereka juga menggunakan teknologi informasi untuk mengembangkan media pembelajaran dan merancang pembelajaran online.Keterampilan menggunakan fungsi-fungsi masih rendah. Kesimpulan dari penelitian ini adalah keterampilan guru dalam menggunakan teknologi informasi dalam pembelajaran di sekolah dasar berada pada kategori sedang. Mengembangkan media pembelajaran dan meningkatkan keterampilan  dalam menggunakan fitur desain pembelajaran online memerlukan bimbingan dan dukungan ahli.Kata kunci: Guru; Keterampilan; Pembelajaran; Sekolah dasar; Teknologi informasi.Abstract: This study aims to describe the skills of teachers using information technology in learning in elementary schools. The research method used is descriptive qualitative research method with preliminary steps, field and data analysis. Sources of data are 8 people at SDN 44 Mataram, 3 male teachers and 5 female teachers. The data collection technique used is observation. The analysis sheet and the teacher's performance observation sheet were used as research tools. The data analysis technique was carried out using qualitative data analysis techniques. The results showed that the teacher's skills in integrating laptops, internet and Infocus in basic education were at the secondary level. Most teachers already understand the use of information technology in learning and can design presentations and display learning materials easily, but they also use information technology to develop learning media and design online learning. Skills in using functions are still low. The conclusion of this study is that the skills of teachers in using information technology in learning in elementary schools are in the medium category. Developing learning media and improving skills in using online learning design features requires expert guidance and support.Keywords: Teachers; Skills; Learning; Elementary school; Information technology.
SOLUSI REALITAS DALAM MENDESAIN PARADIGMA PENDIDIKAN MASA DEPAN
Authors: Ardiansyah Vendra , Nuraini Novi , Panjianum Andi
Published: December 2022

Abstract : The purpose of this study is to identify and describe the reality solutions in designing the future educational paradigm. The method used in this research is a literature study and is included in qualitative descriptive research. The researcher tries to examine various literatures about reality solutions in designing future educational paradigms that are sourced from various scientific journal articles and other book sources. This study was carried out through stages, starting with a literature search and then organizing the study followed by a Content Analytic analysis in order to understand reality solutions in designing future educational paradigms. The results of this study are in the form of descriptions of solutions in solving problems faced by future educational paradigms in terms of two aspects of education, namely traditional education and modern education. Keywords: Solution, Paradigm, Traditional and Modern EducationAbstrak : Tujuan penelitian ini ialah untuk mengetahui dan mendeskripsikan solusi realitas dalam mendesain paradigm pendidikan masa depan. Metode yang digunakan dalam penelitian ini  ialah  kajian studi literature dan termasuk kedalam penelitian deskriptif kualitatif. Peneliti berusaha mengkaji dari berbagai literature tentang solusi realitas dalam mendesain paradigma pendidikan masa depan yang bersumber dari berbagai artikel jurnal ilmiah maupun sumber buku lainnya. Kajian ini dilakukan melalui tahapan tahapan yakni dimulai dari pencarian literature lalu pengorganisasian kajian disambung dengan menganalisis secara Content Analytic guna memahami solusi realitas dalam mendesain paradigma pendidikan di masa depan. Hasil penelitian ini berupa uraian dari solusi dalam pemecahan masalah yang dihadapi paradigam pendidikan masa depan yang ditinjau dari dua aspek pendidikan yakni pendidikan tradisional dan pendidikan modern.Kata Kunci: Solusi, Paradigma, Pendidikan Tradisional dan Modern
IMPLEMENTASI SISTEM PENDIDIKAN NON FORMAL SANTRIWATI YANG BERSEKOLAH MADRASAH ALIYAH DI PONDOK PESANTREN ANWARUL HALIMY SESELE LOMBOK BARAT
Authors: Kholisussa`di Kholisussa`di , Fahmi Agus , Purmadi Ary
Published: December 2022

Abstract: Abstract: Non-formal education is education that can be carried out in stages but is not official and the material is strengthening in formal educational institutions, such as educational units for courses, packages A, B, and C. Islamic non-formal education includes Islamic boarding schools. The focus of the problem is how to implement the non-formal education system for female students. The purpose of the study was to determine the implementation of the non-formal education system "santriwati" who attended Madrasah Aliyah at the Anwarul Halimy Sesele Islamic boarding school, West Lombok. The research method used in this study is a qualitative research method, namely an approach whose research findings are not obtained through statistical procedures or other forms of calculation. The results showed that the Anwarul Halimy Islamic boarding school applied the same learning method as other Islamic boarding schools throughout Indonesia and abroad in general and the materials and books taught or presented were the same as the standards of Islamic boarding schools throughout Indonesia and elsewhere. abroad, because basically the study books discussed have the same reference source.  Keywords: Santriwati Non Formal Education System  Abstrak: Pendidikan non formal adalah pendidikan yang dapat dilakukan secara berjenjang tapi tidak bersifat resmi dan materinya bersifat penguatan pada lembaga pendidikan formal, Seperti satuan pendidikan kursus-kursus, paket A, B, dan C. Pendidikan non formal Islam diantaranya Pesantren. Fokus masalahnya adalah bagaimana Implementasi sistem pendidikan Non Formal santriwati. tujuan penelitian adalah untuk mengetahui Implementasi sistem pendidikan  Non Formal “santriwati” yang bersekolah Madrasah Aliyah di pondok pesantren Anwarul Halimy Sesele Lombok Barat. Metode penelitian yang digunakan pada penelitian ini adalah metode penelitian kualitatif yaitu pendekatan yang temuan-temuan penelitiannya tidak diperoleh melalui prosedur statistik atau bentuk perhitungan lainnya. Hasil penelitian menunjukkan bahwa pondok pesantren Anwarul Halimy menerapkan metode pembelajaran yang sama dengan pembelajaran pondok pesantren lainnya yang ada di seluruh indonesia maupun luar negeri pada umumnya dan materi-materi beserta kitab-kitab yang diajarkan atau disajikan sama dengan standar pondok pesantren di seluruh indonesia maupun di luar negeri, karena pada dasarnya kitab-kitab kajian yang dibahas sumber refrensinya sama.  Kata Kunci: Sistem Pendidikan Non Formal Santriwati
Pear rust in Belarus because of fungus Gymnosporangium sabinae (Dicks.) G. Winter invasion
Authors: Poliksenova Valentina D.
Published: December 2022

Pear rust in Belarus was first registered in 2007, and after 12 years the disease acquired the character of epiphytosis. A map of the distribution of pear rust in the republic has been compiled. The symptoms of damage to pear and juniper, spores of the causative agent (fungus Gymnosporangium sabinae (Dicks.) G. Winter) are described and illustrated. It has been shown that aecio- and teliospores overwintered in the shoots do not germinate in the next growing season. The teliospores of the current year on juniper germinate not only with phragmobasidia with basidiospores, but also with mycelium, which probably ensures the re-infection of this host plant. The high infectious potential of both pear (up to 15 mln aeciospores per 1 cm2 ) and juniper (2 mln teliospores per 1 cm2 ) was determined. The death due to rust of annual shoots of pear and individual plants of the Cossack juniper was ascertained. The invasion of G. sabinae on the territory of Belarus coincides with the wide introduction of susceptible species of juniper into landscaping.
Hemolymph osmolality in mollusk Lymnaea stagnalis during acute experimental hyperglycemia
Authors: Sidorov Alexander V.
Published: December 2022

It has been established that the development of hyperglycemia, accompanied by a multiple increase in the hemolymph glucose content (up to 4.0 – 4.5 mmol/L), doesn’t lead to any significant changes in Lymnaea’ s hemolymph osmolality. Incubation of mollusks in 100 mmol/L aqueous solution of polyethylene glycol 200 for 2 h causes a 1.4-fold increase in hemolymph osmolality (up to 210 mosmol/kg) compared to the control level.
A Stage-Based Approach to the Management of Small Fetuses
Authors:   Department of Obstetrics and Gynecology, CHU Saint-Pierre, Brussels, Belgium., Yannick Hurni , Sara Marcenaro ,   Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland., Caroline Gounongbé ,   Department of Obstetrics and Gynecology, CHU Saint-Pierre, Brussels, Belgium., Giulia Garofalo ,   Department of Obstetrics and Gynecology, CHU Saint-Pierre, Brussels, Belgium.
Published: December 2022

Objective: To analyze data concerning pregnancies with fetal smallness managed with the stage-based management protocol proposed by Figueras and Gratacós in 2014 at a single tertiary center in Belgium.
‘Informal Infrastructure’ of Prototyping: Practicing Organisation by Performing Materiality
Authors: García Sandra Fernández , Valle Francisco Sánchez
Published: December 2022

In recent years, sheltered by the so-called ‘ontological turn’ in the social sciences, organisational analysis has paid special attention to artefacts. Nevertheless, there is still a dominant account grounded in a dichotomist view of the subject-object relationship either in teleological (mind-body) or in hylomorfic (form-matter) terms when analysing organising practices. On the contrary, our argument is based on non-dualistic approaches in an attempt to foreground relational aspects of practices.

From a practice-based approach, the article addresses the role of three ‘prototypes’ aimed at the management of the ‘air’ by citizenship, in the re-configuration of bodies, technics and ethical-political engagement. Specifically, it focuses on the normative dimensions of organising by which knowledges, materials and values converge in the open-ended process of prototyping. The argument is deployed by relying on qualitative research based on multi-sited ethnographic fieldwork, developed both at different workshops and by online ethnography.

The main aim of the article is to show how bodies and artefacts are mutually in/trans/formed when negotiating the social implications for the ontological category of ‘air’. In doing so, the concept of ‘informal infrastructure’ is proposed to account for those practices (which appear somewhat contingent, mundane or, at best, taken for granted) by which agents do not only commit to a particular ethical implication embedded in the category of ‘air’, as a symbolic result, but also to distinctive ways of practicing organisation as a political process of performing materiality. To this end, adopting the analytical concept of ‘informal infrastructure’ allows to simultaneously consider both the formal and informal aspects that emerge in these collaboration-driven practices, as well as to address their effects on the maintenance within and expansion into other networks.
PREDİYABET HASTALARINDA TOTAL BİLİRUBİN VE İSKEMİ MODİFİYE ALBÜMİN İLİŞKİSİ
Authors: POYRAZER Mehmet , KAPLAN EFE Fatma , AKSOY YILMAZ Büşragül , ERTEN Rıdvan , GÜRSOY Gül
Published: December 2022

AMAÇ: Prediyabet (PDM) diyabetin kendisi gibi enflamatuar bir süreçtir. Bu çalışmada PDM hastalarında endojen nonenzimatik antioksidan olan total bilirubin ile kardiak iskemi ve enflamasyon markırı olan iskemi modifiye albümin arasındaki ilişkinin değerlendirilmesi amaçlandı.
MATERYAL-METOD: Çalışmaya kronik hastalıkları olmayan sigara ve alkol kullanmayan ve rutin biyokimyasal analizleri için başvuran 100 olgu dahil edildi. 50 olgu yeni tanı PDM, 50 olgu kontrol grubu olarak belirlendi. Olguların açlık kan örnekleri alındı. 4000 RPM de santrifüj edildi ve plazma kısmı -80 ° C’de saklandı. IMA absorbansı ise Bar-Or’un spektrofotometrik metoduyla analiz edildi. Çalışmamızda IMA düzeyleri bireylerin albümin sonuçlarına göre düzeltildi.
BULGULAR: İskemi modifiye albümin (IMA) ve albümine göre düzeltilmiş İskemi modifiye albümin (D-IMA) PDM hastalarında kontrol grubuna göre istatiksel anlamlı olarak yüksekti Total bilirubin ve IMA ve D-IMA arasında korelasyon saptanmadı. IMA ve D-IMA albümin dışında diğer metabolik parametreler ile de korelasyon saptanmadı. Albümin ile D-IMA ve IMA arasında negatif korelasyon saptandı.
SONUÇ: IMA ve D-IMA düzeylerinin prediyabetik grupta daha yüksek olması prediyabetik hastaların hem aterosklerotik risk faktörleri hem de oksidatif stres açısından kontrol grubuna göre daha fazla risk altında oldugunu düsündürmektedir.
Perbandingan imbuhan awalan kata kerja Bahasa Bajau Kota Belud dan Bajau Semporna
Authors: Mahali Saidatul Nornis , Ismail Mohd Afis
Published: December 2022

Makalah ini bertujuan mendeskripsi awalan kata kerja bahasa Bajau dari daerah Kota Belud dan Semporna, Sabah. Data diperoleh melalui temu bual tidak berstruktur. Kaedah temu bual secara bersemuka dan secara santai dilakukan sambil membuat rakaman terhadap semua aktiviti harian. Aktiviti harian tersebut melibatkan kegiatan ekonomi dan sosial para informan. Analisis menunjukkan terdapat pelbagai bentuk imbuhan dalam kedua-dua bahasa Bajau, namun imbuhan-imbuhan berkenaan memperlihatkan perbezaan ketara antara satu sama lain. Malah, dapatan juga memperlihatkan perbezaan dengan hasil kajian Omar (1983). Bagaimanapun, makalah ini hanya berfokus kepada imbuhan awalan kata kerja m(N) dalam bahasa Bajau Kota Belud yang mempunyai tiga alomorf, iaitu m-, n- dan ng-, dan imbuhan a(N) dalam bahasa Bajau Semporna yang juga memiliki tiga alomorf, iaitu an-, am- dan ang-. Kedua-dua imbuhan awalan tersebut boleh diimbuh dengan semua fonem vokal dan fonem konsonan /p, b, t, d, k, g, h, l, r, dan s/. Didapati juga bahawa imbuhan awalan dalam kedua-dua bahasa ini merupakan imbuhan yang sangat produktif dan boleh diimbuh dengan tiga jenis kata, iaitu kata nama, kata kerja dan kata adjektif.
A critical response to Moshe Chaichian and colleagues on mass dimension one fields, and related matters
Authors: Ahluwalia Dharam , Lee Cheng-Yang
Published: December 2022

In a recent article published in EPJC, Moshe Chaichian and colleagues have presented an overarching critique of mass dimension one fields and related matters. In this Letter we show without ambiguity where these authors go wrong.
Robust automatic hexahedral cartilage meshing framework enables population-based computational studies of the knee
Authors: Gibbons Kalin D. , Malbouby Vahid , Alvarez Oliver , Fitzpatrick Clare K.
Published: December 2022

Osteoarthritis of the knee is increasingly prevalent as our population ages, representing an increasing financial burden, and severely impacting quality of life. The invasiveness of in vivo procedures and the high cost of cadaveric studies has left computational tools uniquely suited to study knee biomechanics. Developments in deep learning have great potential for efficiently generating large-scale datasets to enable researchers to perform population-sized investigations, but the time and effort associated with producing robust hexahedral meshes has been a limiting factor in expanding finite element studies to encompass a population. Here we developed a fully automated pipeline capable of taking magnetic resonance knee images and producing a working finite element simulation. We trained an encoder-decoder convolutional neural network to perform semantic image segmentation on the Imorphics dataset provided through the Osteoarthritis Initiative. The Imorphics dataset contained 176 image sequences with varying levels of cartilage degradation. Starting from an open-source swept-extrusion meshing algorithm, we further developed this algorithm until it could produce high quality meshes for every sequence and we applied a template-mapping procedure to automatically place soft-tissue attachment points. The meshing algorithm produced simulation-ready meshes for all 176 sequences, regardless of the use of provided (manually reconstructed) or predicted (automatically generated) segmentation labels. The average time to mesh all bones and cartilage tissues was less than 2 min per knee on an AMD Ryzen 5600X processor, using a parallel pool of three workers for bone meshing, followed by a pool of four workers meshing the four cartilage tissues. Of the 176 sequences with provided segmentation labels, 86% of the resulting meshes completed a simulated flexion-extension activity. We used a reserved testing dataset of 28 sequences unseen during network training to produce simulations derived from predicted labels. We compared tibiofemoral contact mechanics between manual and automated reconstructions for the 24 pairs of successful finite element simulations from this set, resulting in mean root-mean-squared differences under 20% of their respective min-max norms. In combination with further advancements in deep learning, this framework represents a feasible pipeline to produce population sized finite element studies of the natural knee from subject-specific models.
Large-conductance Ca2 +-activated K+ channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells
Authors: Wang Meili , Li Shuanglei , Liu Hongshan , Liu Mingyuan , Zhang Jin , Wu Yang , Xiao Cangsong , Huang Haixia
Published: December 2022

Background

Vascular smooth muscle cells (VSMCs) phenotype switching is very important during the pathogenesis and progression of vascular diseases. However, it is not well understood how normal VSMCs maintain the differentiated state. The large-conductance Ca2+-activated K+ (BKCa) channels are widely expressed in VSMCs and regulate vascular tone. Nevertheless, there is limited understanding of the role of the BKCa channel in modulation of the VSMC phenotype.

Methods and results

We assessed BKCa channel expression levels in normal and injured carotid arteries from rats of the balloon-injury model. A strong decrease of BKCa-β1 was seen in the injured carotid arteries, accompanied by a parallel decrease of the VSMC contractile markers. BKCa-β1 in primary rat aortic VSMCs was decreased with the increase of passage numbers and the stimulation of platelet-derived growth factor (PDGF)-BB. Conversely, transforming growth factor β upregulated BKCa-β1. Meanwhile, the BKCa-β1 level was positively associated with the levels of VSMC contractile proteins. Intravenous injection of PDGF-BB induced downregulation of BKCa-β1 expression in the carotid arteries. Knockdown of BKCa-β1 favored VSMC dedifferentiation, characterized by altered morphology, abnormal actin fiber organization, decreased contractile proteins expression and reduced contractile ability. Furthermore, the resultant VSMC dedifferentiated phenotype rendered increased proliferation, migration, enhanced inflammatory factors levels, and matrix metalloproteinases activity. Studies using primary cultured aortic VSMCs from human recapitulated key findings. Finally, protein level of BKCa-β1 was reduced in human atherosclerotic arteries.

Conclusion

BKCa-β1 is important in the maintenance of the contractile phenotype of VSMCs. As a novel endogenous defender that prevents pathological VSMC phenotype switching, BKCa-β1 may serve as a potential therapeutic target for treating vascular diseases including post-injury restenosis and atherosclerosis.
Impact of turbulence on magnetic alignment in sediments
Authors: Philippe Édouard G. H. , Valet Jean-Pierre , St-Onge Guillaume , Egli Ramon
Published: December 2022

Rapidly deposited layers (RDL) such as turbidites or hyperpycnites are mostly studied for their sedimentological properties, but are carefully avoided in paleomagnetic studies due to the disturbances caused by such sudden and rapid sediment accumulation. Therefore, these layers can also be seen as potential indicators of sediment parameters susceptible of affecting the alignment of magnetic grains and ultimately the acquisition of the natural remanent magnetization (NRM). We have compiled 13 Holocene rapidly deposited layers from core MD99-2222 in the Saguenay Fjord, eastern Canada (St-Onge and al., 2004) with varying thicknesses (from 7.1 cm to 1,510 cm) and 4 Quaternary turbidites of different origins, to document the influence of sedimentary and magnetic parameters on natural remanent magnetization acquisition. We found a logarithmic relationship between rapidly deposited layers thickness on the one hand, and the amplitude of inclination changes and magnetic grain sizes on the other. Inclination and magnetic grain sizes are themselves correlated to each other by a logarithmic law. As there is no relationship between inclination deviation and stratigraphic depth, compaction alone cannot account for such large effects on inclination. Flocculation is grain size sensitive, but it is expected to affect mainly the natural remanent magnetization intensity, rather than its direction. Turbulence that prevails during the rapid deposition of sediments during such events is most likely the dominant factor.
Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review
Authors: Perez Luis C. , Perez Laura T. , Nene Yash , Umpierrez Guillermo E. , Davis Georgia M. , Pasquel Francisco J.
Published: December 2022

Background

Brown adipose tissue (BAT) plays a role in modulating energy expenditure. People with obesity have been shown to have reduced activation of BAT. Agents such as β-agonists, capsinoids, thyroid hormone, sildenafil, caffeine, or cold exposure may lead to activation of BAT in humans, potentially modulating metabolism to promote weight loss.

Methods

We systematically searched electronic databases for clinical trials testing the effect of these agents and cold exposure on energy expenditure/thermogenesis and the extent to which they may impact weight loss in adults.

Results

A total of 695 studies from PubMed, Web of Science, and Medline electronic databases were identified. After the removal of duplicates and further evaluation, 47 clinical trials were analyzed. We observed significant heterogeneity in the duration of interventions and the metrics utilized to estimate thermogenesis/energy expenditure. Changes observed in energy expenditure do not correlate with major weight changes with different interventions commonly known to stimulate thermogenesis. Even though cold exposure appears to consistently activate BAT and induce thermogenesis, studies are small, and it appears to be an unlikely sustainable therapy to combat obesity. Most studies were small and potential risks associated with known side effects of some agents such as β-agonists (tachycardia), sibutramine (hypertension, tachycardia), thyroid hormone (arrhythmias) cannot be fully evaluated from these small trials.

Conclusion

Though the impact of BAT activation and associated increases in energy expenditure on clinically meaningful weight loss is a topic of great interest, further data is needed to determine long-term feasibility and efficacy.
Occupational and domestic physical activity and diabetes risk in adults: Results from a long-term follow-up cohort
Authors: Wang Jialu , He Liyun , Yang Na , Li Ziyi , Xu Lingling , Li Wei , Ping Fan , Zhang Huabing , Li Yuxiu
Published: December 2022

Background

Physical activity (PA) has been associated with decreased incidence of diabetes. However, few studies have evaluated the influence of occupational and domestic PA on the risk of diabetes with a long-term follow-up. We aimed to examine the association between occupational and domestic PA and the risk of diabetes in a long-term prospective cohort of Chinese adults.

Methods

A total of 10,343 adults who were followed up in the China Health and Nutrition Survey from 1997 to 2015 were included in our analysis. Occupational and domestical PA were collected with detailed seven-day data and were converted into metabolic equivalents values. Total PA included occupational, domestic, transportation, and leisure time PA. Diabetes cases were identified by self-reported doctor/health professional diagnosis of diabetes, fasting blood glucose ≥7.0 mmol/L, and glycosylated hemoglobin (HbA1c) ≥6.5%. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI).

Results

During up to 18 years of follow-up (median 10 years), there were 575 diabetes cases documented. Occupational PA accounted for the majority of total PA (68%) in Chinese population, followed by domestic PA (25%). With adjustments for possible covariates, the highest quartiles of total PA (HR, 0.728 [95% CI, 0.570–0.929]) and occupational PA (HR, 0.765 [95% CI, 0.596–0.982]) were significantly associated with a lower risk of diabetes compared with lowest quartiles. The association between domestic PA and the risk of diabetes was insignificant (P >0.05).

Conclusion

Higher levels of occupational PA were associated with a decreased risk of diabetes risk in the Chinese population. Domestic PA was not associated with the incidence of diabetes.
The cryopreservation process induces alterations in proteins associated with bull sperm quality: The equilibration process could be a probable critical control point
Authors: Arunkumar Ramasamy , Kumaresan Arumugam , Sinha Manish Kumar , Elango Kamaraj , Ebenezer Samuel King John Peter , Nag Pradeep , Karuthadurai Thirumalaisamy , Baithalu Rubina Kumari , Mohanty Tushar Kumar , Kumar Rakesh , Datta Tirtha Kumar
Published: December 2022

The present study quantitatively characterized the proteomic changes in bull spermatozoa induced by the cryopreservation process. We performed high-throughput comparative global proteomic profiling of freshly ejaculated (before cryopreservation), equilibrated (refrigerated storage; during cryopreservation), and frozen (ultralow temperature; after cryopreservation) bull spermatozoa. Using the liquid chromatography–mass spectrometry (LC-MS/MS) technique, a total of 1,692, 1,415, and 1,286 proteins were identified in fresh, equilibrated, and cryopreserved spermatozoa, respectively. When the proteome of fresh spermatozoa was compared with equilibrated spermatozoa, we found that 166 proteins were differentially expressed. When equilibrated spermatozoa were compared with cryopreserved spermatozoa, we found that 147 proteins were differentially expressed between them. Similarly, we found that 156 proteins were differentially expressed between fresh and cryopreserved spermatozoa. Among these proteins, the abundance of 105 proteins was lowered during the equilibration process itself, while the abundance of 43 proteins was lowered during ultralow temperature preservation. Remarkably, the equilibration process lowered the abundance of sperm proteins involved in energy metabolism, structural integrity, and DNA repair and increased the abundance of proteins associated with proteolysis and protein degradation. The abundance of sperm proteins associated with metabolism, cGMP-PKG (cyclic guanosine 3′,5′-monophosphate-dependent protein kinase G) signaling, and regulation of the actin cytoskeleton was also altered during the equilibration process. Collectively, the present study showed that the equilibration step in the bull sperm cryopreservation process was the critical point for sperm proteome, during which a majority of proteomic alterations in sperm occurred. These findings are valuable for developing efficient protocols to minimize protein damage and to improve the quality and fertility of cryopreserved bull spermatozoa.
Clinical outcome analysis of frozen-thawed embryo transfer on Day 7
Authors: Liu Xinmi , Lou Hua , Zhang Junwei , Du Mingze , Du Yulin , Wu Shanshan , Guan Yichun , Liu Jing
Published: December 2022

Objective

To investigate the clinical outcomes of Day 7 (D7) frozen-thawed embryo transfer (FET) and to provide a reference value for clinical work.

Methods

This was a retrospective cohort study. Patients undergoing FET cycles in the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University between December 2015 and January 2021 were included. According to the developmental stage of the embryos at transfer, the embryos were divided into three groups: Day (D) 5, D6 and D7 blastocysts. Group D7 was compared with Groups D5 and D6. Simultaneously, the preimplantation genetic testing (PGT) and non-PGT cycles in Group D7 were analyzed and compared. The main outcomes were the clinical pregnancy, live birth and miscarriage rates. The secondary outcomes were the implantation and euploidy rates.

Results

In total, 5945, 4094 and 137 FET cycles were included in the D5, D6 and D7 groups, respectively. The clinical pregnancy rate was significantly lower in Group D7 than in Groups D5 (13.9% vs 62.9%, P <0.001) and D6 (13.9% vs 51.4%, P <0.001). Additionally, the live birth rate was significantly lower in Group D7 than in Groups D5 (7.3% vs 50.7%, P <0.001) and D6 (7.3% vs 40.5%, P <0.001). However, the miscarriage rate was significantly higher in Group D7 than in Groups D5 (47.4% vs 18.2%, P =0.001) and D6 (47.4% vs 20.6%, P =0.004). The clinical pregnancy and live birth rates for D7 blastocysts were significantly higher in the PGT group than in the non-PGT group (41.7% vs 13.9%, P=0.012; 33.3% vs 7.3%, P =0.003).

Conclusions

D7 blastocyst transfer can yield a live birth rate that is lower than that for D5 and D6 blastocysts but has value for transfer. PGT for D7 blastocysts may reduce the number of ineffective transfers and improve the outcome of D7 blastocyst transfer, which can be performed according to a patient’s situation.
Bibliometric and visualization analysis of literature relating to diabetic erectile dysfunction
Authors: Meng Fanchao , Liao Xiaoxing , Chen Haimin , Deng Sheng , Wang Lu , Zhao Mengjie , Li Haibin , Liu Dong , Gao Guojing , Li Haisong , Wang Jisheng
Published: December 2022

Introduction

Diabetic erectile dysfunction (DMED) refers to erectile dysfunction secondary to diabetes. Erectile dysfunction is characterized by a persistent inability to achieve and maintain an erection sufficient to permit satisfactory sexual activity.

Methods

Based on the Web of Science core collection database, we firstly analyzed the quantity and quality of publications in the field of DMED, secondly profiled the publishing groups in terms of country, institution, author’s publication and cooperation network, and finally sorted out and summarized the hot topics of research.

Results

From 2001 to 2022, a total of 1,403 articles relating to this topic were published in 359 journals. They represent the global research status, potential hotspots, and future research directions. The number of DMED-related publications and citations has steadily increased over the few past decades. Academic institutions from Europe and the United States have played a leading role in DMED research. The country, institution, journal, and author with the most publications were the United States (294), INHA University (39), the Journal of Sexual Medicine (156), and Ryu, Ji-Kan (29), respectively. The most common keywords were erectile dysfunction (796), men (256), diabetes (254), diabetes mellitus (239), prevalence (180), corpus cavernosum (171), dysfunction (155), mellitus (154), nitric-oxide synthase (153), and expression (140). The main keyword-based research topics and hotspots in the DMED field were oral sildenafil, smooth muscle relaxation, nitric oxide synthase, gene therapy, metabolic syndrome, cavernous nerve injury, stem cell, and penile prosthesis.

Discussion

The terms oral sildenafil, smooth muscle relaxation, nitric oxide synthase, gene therapy, metabolic syndrome, cavernous nerve injury, stem cell, and penile prosthesis will be at the forefront of DMED-related research.
Epidemiological trends in the presentation of diabetic ketoacidosis in children newly diagnosed with type 1 diabetes from 2011 to 2017 in Kuwait
Authors: Al-Abdulrazzaq Dalia , Othman Fouzeyah , Qabazard Sarah , Al-Tararwa Abeer , Ahmad Dina , Al-Sanae Hala , Al-Kandari Hessa
Published: December 2022

Background

Monitoring the trends in the presentation of T1D over decades cannot be underestimated as it provides a rich source of information on diabetes-related complications like DKA. DKA represents a medical emergency, with potentially fatal outcome, and thus the prevention of DKA is a priority in diabetes care. The aim of this study is to report on trends in the presentation of DKA in children newly diagnosed with T1D in Kuwait.

Material and methods

This study is based on a retrospective review of children newly diagnosed with T1D aged 14 years or less at three Governmental Hospitals representing three health sectors out of the total six health sectors in the country during the period 2011-2017.

Results

A total of 799 children (376 males and 423 females) were newly diagnosed with T1D. 287 children presented with DKA (35.9%) with only 73 children (9.1%) classified as severe. During the years 2011 to 2017, we note that the percentage of children older than 6 years of age presenting with severe DKA has decreased significantly (p=0.022). Unfortunately, this has not been replicated in children younger than 6 years.

Conclusion

This study highlights the importance of continued monitoring of clinical characteristics of children at diagnosis of T1D specifically presenting with DKA to enable diabetes care professionals to appreciate the multifaceted aspects of T1D, in particular the importance of raising awareness of the early signs of the onset of T1D with special attention to DKA and its severe consequences.