bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilization of Diagnostic Testing for Renal Anomalies and Congenital Heart Disease in Patients with Microtia
Authors: Ramprasad Vaibhav H. , Shaffer Amber D. , Jabbour Noel
Published: January 2020

Objective

Congenital ear anomalies are associated with congenital cardiac and renal defects. Renal ultrasounds, electrocardiogram, and echocardiogram can be utilized for diagnosis of these concurrent defects. No standard of care exists for the workup of patients with microtia. The goals of this study were to describe the utilization of diagnostic testing for cardiac and renal anomalies and to identify their prevalence in patients with microtia.

Study Design

Case series with chart review.

Setting

Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center.

Subjects and Methods

This study is an Institutional Review Board–approved retrospective review of consecutive patients born between 2002 and 2016 who were diagnosed with microtia and seen in the otolaryngology clinic at a tertiary care children’s hospital. Demographics, sidedness and grade of microtia, comorbid diagnoses, and details of renal and cardiovascular evaluations were recorded. Factors associated with retroperitoneal ultrasound and cardiac testing were assessed with logistic regression.

Results

Microtia was present in 102 patients, and 98 patients were included as they received follow‐up. Microtia was associated with craniofacial syndrome in 34.7% of patients. Renal ultrasound was performed in 64.3% of patients, and 12.9% of patients with ultrasounds had renal aplasia. Cardiac workup (electrocardiogram or echocardiogram) was completed in 60.2% of patients, and of this subset, 54.2% had a congenital heart defect.

Conclusion

Diagnostic testing revealed renal anomalies and cardiac defects in patients with isolated microtia at a higher rate than in the general population. This suggests the need for further evaluation of the role of routine screening in patients with microtia.
A Surgical Simulator for Tympanostomy Tube Insertion Incorporating Capacitive Sensing Technology to Track Instrument Placement
Authors: Vaitaitis Vilija J. , Dunham Michael E. , Kwon Yong‐Chan , Mayer Wyatt C. , Evans Adele K. , Baker Amari J. , Walker Kyla D. , Cespedes Gabriel D. , Stanley Abishek , Opiri Michelle
Published: January 2020

We describe a device engineered for realistic simulation of myringotomy and tympanostomy tube insertion that tracks instrument placement and objectively measures operator proficiency. A 3‐dimensional computer model of the external ear and cartilaginous external auditory canal was created from a normal maxillofacial computed tomography scan, and models for the bony external auditory canal and tympanic cavity were created with computer‐aided design software. Physical models were 3‐dimensionally printed from the computer reconstructions. The external auditory canal and tympanic cavity surfaces were coated with conductive material and wired to a capacitive sensor interface. A programmable microcontroller with custom embedded software completed the system. Construct validation was completed by comparing the run times and total sensor contact times of otolaryngology faculty and residents.
Abnegation, accommodation and affirmation: Three discursive modes for the institutional construction of independence among national news agency executives in Europe
Authors: Rantanen Terhi , Kelly Anthony
Published: January 2020

The relationship between the ownership form of news agencies and their independence has long figured centrally in debates about the quality of news agency operations. Drawing on a discursive institutional framework, this article explores how national news agency executives in Europe perform a narrated role in the discursive construction of their organizations’ internal and external independence. We set out the concept of independence discourse, which we define as the variety of ways in which news agency executives use claims about the economic independence and the internal and external autonomy of their organizational operations. Based on a discourse analysis of elite semi-structured interviews with 20 European news agency executives, we identify three discursive modes for the institutional construction of independence: (1) abnegation, (2) accommodation and (3) affirmation. These discursive modes represent a set of public and private approaches to discursively negotiating the power of both state/government and shareholders/owners. We conclude by arguing for an expanded concept of independence, one which offers an account of the complex array of forces shaping news agency operations today.
A Regression Discontinuity Design for Studying Divided Government
Authors: Kirkland Patricia A. , Phillips Justin H.
Published: January 2020

The regression discontinuity design (RDD) is a valuable tool for identifying causal effects with observational data. However, applying the traditional electoral RDD to the study of divided government is challenging. Because assignment to treatment in this case is the result of elections to multiple institutions, there is no obvious single forcing variable. Here, we use simulations in which we apply shocks to real-world election results in order to generate two measures of the likelihood of divided government, both of which can be used for causal analysis. The first captures the electoral distance to divided government and can easily be utilized in conjunction with the standard sharp RDD toolkit. The second is a simulated probability of divided government. This measure does not easily fit into a sharp RDD framework, so we develop a probability restricted design (PRD) which relies upon the underlying logic of an RDD. This design incorporates common regression techniques but limits the sample to those observations for which assignment to treatment approaches “as-if random.” To illustrate both of our approaches, we reevaluate the link between divided government and the size of budget deficits.
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions
Authors: Yoshida Noriaki , Shigemori Kay , Donaldson Nicholas , Trevisani Christopher , Cordero Nicolas A. , Stevenson Kristen E. , Bu Xia , Arakawa Fumiko , Takeuchi Mai , Ohshima Koichi , Yoda Akinori , Ng Samuel Y. , Weinstock David M.
Published: January 2020

Adult T-cell leukemia/lymphoma (ATLL) in Japan presents at a median age of 70 years and only 5% of patients are <50 years of age. We conducted RNA and targeted DNA sequencing of 8 ATLLs from Japanese patients <50 years of age and identified 3 (37.5%) with both CTLA4-CD28 and inducible costimulator (ICOS)-CD28 fusions. Mutations of PLCG1, PRKCB, and STAT3, which were frequent in other ATLL-sequencing studies, were not identified. Differential expression analysis identified the negative checkpoint molecule LAG3 as the most downregulated gene among cases with the fusions. Immunohistochemistry demonstrated expression of CD80 and CD86, the ligands for CTLA4 and CD28, on ATLL cells and tumor-associated macrophages, respectively. Expression of CTLA4-CD28 in Ba/F3 cells conferred cytokine-independent growth when cocultured with Raji cells that express CD80 and CD86. Growth was associated with recruitment of the p85 subunit of phosphatidylinositol 3-kinase to CTLA4-CD28 and phosphorylation of AKT and extracellular signal-regulated kinase. A CTLA4-blocking antibody reduced cytokine-independent growth in a dose-dependent manner. Together, these results suggest that young Japanese ATLL cases have a unique biology dependent on cell-nonautonomous interactions that drive CD28 signaling. Assessment for CD28 fusions and treatment with CTLA4 blockade should be considered in younger patients with relapsed/refractory ATLL.
Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations
Authors: Pangallo Joseph , Kiladjian Jean-Jacques , Cassinat Bruno , Renneville Aline , Taylor Justin , Polaski Jacob Tyler , North Khrystyna Dilai , Abdel-Wahab Omar , Bradley Robert K
Published: January 2020

Genes encoding the RNA splicing factors SF3B1, SRSF2, and U2AF1 are subject to frequent missense mutations in clonal hematopoiesis and diverse neoplastic diseases. Most "spliceosomal" mutations affect specific hotspot residues, resulting in splicing changes that promote disease pathophysiology. However, a subset of patients carry spliceosomal mutations that affect non-hotspot residues, whose potential functional contributions to disease are unstudied. Here, we undertook a systematic characterization of diverse rare and private spliceosomal mutations to infer their likely disease relevance. We utilized isogenic cell lines and primary patient materials to discover that 11 of 14 studied rare and private mutations in SRSF2 and U2AF1 induced distinct splicing alterations, including partially or completely phenocopying the alterations in exon and splice site recognition induced by hotspot mutations or driving "dual" phenocopies that mimicked two co-occurring hotspot mutations. Our data suggest that many rare and private spliceosomal mutations contribute to disease pathogenesis and illustrate the utility of molecular assays to inform precision medicine by inferring the potential disease relevance of newly discovered mutations.
Progressive or Relapsed Burkitt Lymphoma or Leukemia in Children and Adolescents after BFM-type First-line Therapy
Authors: Woessmann Wilhelm , Zimmermann Martin , Meinhardt Andrea , Mueller Stephanie , Hauch Holger , Knörr Fabian , Oschlies Ilske , Klapper Wolfram , Niggli Felix , Kabickova Edita , Attarbaschi Andishe , Reiter Alfred , Burkhardt Birgit
Published: January 2020

Children with refractory or relapsed Burkitt lymphoma have a poor chance to survive. We describe characteristics, outcome, re-induction and transplantation-approaches and evaluate risk factors among children with progression of a Burkitt lymphoma/leukemia included in NHL-BFM studies between 1986 and 2016. Treatment recommendation was re-induction including rituximab from the early 2000s followed by blood stem cell transplantation. The 3-year survival of the 157 children was 18.5{plus minus}3%. Survival significantly improved from 11{plus minus}3% before to 27{plus minus}5% after 2000 (p<.001) allowing for risk factor analyses among the latter 75 patients, of whom 28 had disease progressive during initial therapy. Survival of 14 patients with relapse after initial therapy for low risk disease (R1/R2) was 50{plus minus}13% compared to 21{plus minus}5% for 61 patients progressing after R3/R4-therapy (p<.02). 25 of 28 patients with progression during first-line therapy, 31 of 32 with progression during re-induction, 15 of 16 not reaching a complete remission before transplantation, 9 of 10 treated with rituximab front-line and all 13 patients not receiving rituximab during re-induction died. 46 patients received stem cell transplantation (20 autologous, 26 allogeneic). Survival after a regimen combining Rituximab with continuous-infusion chemotherapy followed by allogeneic transplantation was 67{plus minus}12% compared to 18{plus minus}5% for all other regimen and transplantations (p=.003). Patients with relapsed Burkitt lymphoma/leukemia have a poor chance to survive after current effective front-line therapies. Progression during initial or re-induction chemotherapy and initial high-risk disease are risk-factors in relapse. Time-condensed continuous-infusion re-induction followed by stem cell transplantation forms the basis for testing new drugs.
Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: a propensity score matching analysis
Authors: Minoda Yosuke , Chinen Takatoshi , Osoegawa Takashi , Itaba Soichi , Haraguchi Kazuhiro , Akiho Hirotada , Aso Akira , Sumida Yorinobu , Komori Keishi , Ogino Haruei , Ihara Eikichi , Ogawa Yoshihiro
Published: January 2020

Background

Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the gold standard for diagnosing gastric subepithelial lesions, alternative open biopsy procedures, such as mucosal incision-assisted biopsy (MIAB) has been reported useful. The aim of this study is to evaluate the efficacy of MIAB for the diagnosis of gastric SELs compared with EUS-FNAB.

Methods

We retrospectively analyzed medical records of 177 consecutive patients with gastric SELs who underwent either MIAB or EUS-FNAB at five hospitals in Japan between January 2010 and January 2018. Diagnostic yield, procedural time, and adverse event rates for the two procedures were evaluated before and after propensity-score matching.

Results

No major procedure-related adverse events were observed in either group. Both procedures yielded highly-accurate diagnoses once large enough samples were obtained; however, such successful sampling was more often accomplished by MIAB than by EUS-FNAB, especially for small SELs. As a result, MIAB provided better diagnostic yields for SELs smaller than 20-mm diameter. The diagnostic yields of both procedures were comparable for SELs larger than 20-mm diameter; however, MIAB required significantly longer procedural time (approximately 13 min) compared with EUS-FNAB.

Conclusions

Although MIAB required longer procedural time, it outperformed EUS-FNAB when diagnosing gastric SELs smaller than 20-mm diameter.
Risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease
Authors: Yu Xindi , Chen Maolin , Liu Xu , Chen Yiwei , Hao Zedong , Zhang Haibo , Wang Wei
Published: January 2020

Background

The aim of our study was to analyze the risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease (CHD).

Methods

We performed a retrospective cohort study, and children with CHD who underwent open-heart surgeries at Shanghai Children’s Medical Center from January 1, 2012 to December 31, 2018 were included. The baseline characteristics of these patients of different ages, including neonates (0–1 months old), infants (1–12 months old) and children (1–10 years old), were analyzed, and the association of risk factors with postoperative nosocomial infection were assessed.

Results

A total of 11,651 subjects were included in the study. The overall nosocomial infection rate was 10.8%. Nosocomial infection rates in neonates, infants, and children with congenital heart disease were 32.9, 15.4, and 5.2%, respectively. Multivariate logistic regression analysis found age (OR 0798, 95%CI: 0.769–0.829;P < 0.001), STS risk grade (OR 1.267, 95%CI: 1.159–1.385; P < 0.001), body mass index (BMI) <5th percentile (OR 1.295, 95%CI: 1.023–1.639;P = 0.032), BMI >95th percentile (OR 0.792, 95%CI: 0.647–0.969;P = 0.023), cardiopulmonary bypass (CPB) time (OR 1.008, 95%CI: 1.003–1.012;P < 0.001) and aortic clamping time (OR 1.009, 1.002–1.015;P = 0.008) were significantly associated with nosocomial infection in CHD infants. After adjusted for confounding factors, we found STS risk grade (OR 1.38, 95%CI: 1.167–1.633;P < 0.001), BMI < 5th percentile (OR 1.934, 95%CI: 1.377–2.715;P < 0.001), CPB time (OR 1.018, 95%CI: 1.015–1.022; P < 0.001), lymphocyte/WBC ratiocut off value (OR 1.546, 95%CI: 1.119–2.136;P = 0.008) were significantly associated with nosocomial infection in CHD children.

Conclusion

Our study suggested STS risk grade, BMI, CPB duration, low lymphocyte/WBC or high neutrophil/WBC ratio were independently associated with nosocomial infection in CHD infant and children after cardiac surgery.
Mindfulness for pain, depression, anxiety, and quality of life in people with spinal cord injury: a systematic review
Authors: Hearn Jasmine Heath , Cross Ainslea
Published: January 2020

Background

Populations with reduced sensory and motor function, such as spinal cord injury (SCI) are at increased risk of depression, anxiety, pain, and poorer quality of life (QoL). Mindfulness-Based Interventions (MBIs) have been developed with the aim of improving outcomes for people with SCI. To understand the value of MBIs, a systematic review was conducted pertaining to the use of MBIs, and interventions including elements of mindfulness, with people with SCI.

Methods

Databases were reviewed from 1996 to October 2018 (updated January 2020). Eligibility criteria included the assessment of at least one of the common secondary consequences of SCI (i.e. risk of depression, anxiety, pain, and QoL), describe the use of mindfulness training as a component part of an intervention, or as the whole intervention. The Cochrane Collaboration Risk of Bias and The Effective Public Health Practice Project Quality Assessment Tools were utilised for quality appraisals. Two assessors appraised the studies and demonstrated good agreement (Cohen’s k = .848, p < .001).

Results

Five papers met the inclusion criteria, and demonstrated a range of results of interventions delivered individually, in a group format, in person, and online. Only one study reported significant reductions in pain-related outcomes (with moderate effect sizes), with the remaining studies (n = 4) demonstrating no change. Four studies described reductions in depressive symptoms and three reported reductions in anxiety. Despite the importance of good QoL as a goal for people with SCI, few studies (n = 2) assessed this as an outcome with no improvements reported. Study quality ranged from high to low/weak.

Conclusions

The findings in this review provide mixed support for the use of mindfulness to improve outcomes after SCI. In particular, findings indicate that mindfulness may be particularly effective for improving symptoms of depression and anxiety. This review highlights the requirement for more rigorous, high-quality research, particularly larger randomised-controlled trials with long-term follow-up, in this area. The small number of studies included in the present review mean that conclusions drawn are preliminary and thus reflects the paucity of the research in the area to date.
Correction to: Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation
Authors: Kindermann Anke , Binder Leonore , Baier Jan , Gündel Beate , Simm Andreas , Haase Roland , Bartling Babett
Published: January 2020

Following publication of the original article [1], the authors flagged that the article had published with an error in ‘Table 1’.
Correction to: The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR
Authors: Phommasone Koukeo , van Leth Frank , Imwong Mallika , Henriques Gisela , Pongvongsa Tiengkham , Adhikari Bipin , Peto Thomas J. , Promnarate Cholrawee , Dhorda Mehul , Sirithiranont Pasathorn , Mukaka Mavuto , Peerawaranun Pimnara , Day Nicholas P. J. , Cobelens Frank , Dondorp Arjen M. , Newton Paul N. , White Nicholas J. , von Seidlein Lorenz , Mayxay Mayfong
Published: January 2020

Following publication of the original article [1], it was brought to the authors’ attention that one of the names in the author list had been provided with the incorrect spelling.
Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts
Authors: Kovács Dávid , Igaz Nóra , Marton Annamária , Rónavári Andrea , Bélteky Péter , Bodai László , Spengler Gabriella , Tiszlavicz László , Rázga Zsolt , Hegyi Péter , Vizler Csaba , Boros Imre M. , Kónya Zoltán , Kiricsi Mónika
Published: January 2020

Background

Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth and metastatic dissemination, therapeutic strategies targeting tumour stroma are still not common in the clinical practice. Metal-based nanomaterials have been shown to exert excellent cytotoxic and anti-cancerous activities, however, their effects on the reactive stroma have never been investigated in details. Thus, using feasible in vitro and in vivo systems to model tumour microenvironment, we tested whether the presence of gold, silver or gold-core silver-shell nanoparticles exerts anti-tumour and metastasis suppressing activities by influencing the tumour-supporting activity of stromal fibroblasts.

Results

We found that the presence of gold-core silver-shell hybrid nanomaterials in the tumour microenvironment attenuated the tumour cell-promoting behaviour of CAFs, and this phenomenon led to a prominent attenuation of metastatic dissemination in vivo as well. Mechanistically, transcriptome analysis on tumour-promoting CAFs revealed that silver-based nanomaterials trigger expressional changes in genes related to cancer invasion and tumour metastasis.

Conclusions

Here we report that metal nanoparticles can influence the cancer-promoting activity of tumour stroma by affecting the gene expressional and secretory profiles of stromal fibroblasts and thereby altering their intrinsic crosstalk with malignant cells. This potential of metal nanomaterials should be exploited in multimodal treatment approaches and translated into improved therapeutic outcomes.
HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients
Authors: Basmaeil Yasser S. , Algudiri Dana , Alenzi Reem , Al Subayyil Abdullah , Alaiya Ayodele , Khatlani Tanvir
Published: January 2020

Background

Preeclampsia is a common obstetric syndrome affecting women in their first pregnancy and characterized by hypertension and proteinuria, which appears after 20 weeks of gestation. It is characterized by high blood pressure and occasional damage to another organ system most often the liver and kidneys. Currently, the etiology and pathogenesis of this syndrome are not fully understood. Since mesenchymal stem cells/stromal cells (MSCs) are intimately associated with endothelial cells that line vessel walls in the decidua they may play some role in the pathogenesis of this syndrome. In this study, we have partly, unveiled the mechanism of preeclampsia pathogenesis at the stem cells level.

Methods

We have isolated and characterized MSCs from decidua basalis of preeclampsia placenta (PE-DBMSCs) and showed their decreased functionality in terms of proliferation, migration, adhesion and clone formation potential as compared to MSCs isolated from decidua region of normal placentae (DBMSCs). The cells were preconditioned with H2O2 and the functional characteristics were evaluated. Differentially expressed genes were analyzed using mass spectrometry. Immunoblotting confirmed the expression of these proteins.

Results

Pre-conditioning with H2O2 restored the functional outcome of PE-DBMSCs. Mass spectrometry (MS) analysis of differentially expressed proteins revealed HMOX1 as one of the major candidates missing in PE-DBMSCs. HMOX1 inhibition by tin protoporphyrin (SnPP) in normal DBMSCs resulted in a reduction in proliferation, migration, adhesion, and clone formation processes as compared to the untreated controls. mRNA and protein analyses of PE-DBMSCs preconditioned with H2O2 at lower doses showed upregulation of HMOX1 expression.

Conclusions

We hereby show for the first time that loss of function of stem cells/stromal cells isolated from the patients with preeclampsia may contribute towards the disease exacerbation. Our results suggest that HMOX1 may be partially responsible for the loss of functionality in PE-DBMSCs and contribute significantly towards the pathophysiology of preeclampsia. However, further investigation is required to decipher its exact role in the development and onset of the disorder.
Alternative application approach on black bean: hair coloring product
Authors: Inman Chiraporn , Lourith Nattaya , Kanlayavattanakul Mayuree
Published: January 2020

Background

Black bean is one of the important beans as the second most consumed bean globally after soybean. It has been reported as a sustainable source of anthocyanins, important natural colorants used in food and consumer products. However, industrial uses of black bean anthocyanins in pharmaceutics and cosmetics have rarely been explored. Thus, here, a black bean anthocyanin extract was prepared, quality controlled and developed into an efficient hair coloring product.

Results

Black bean was macerated in hydrochloric ethanol to produce a dark-reddish 1.85 ± 0.04% dry extract with total anthocyanin content (TAC) of 1.24 ± 0.48 µg/ml cyanidin-3-glucoside. The extract was readily dissolved in propylene glycol (25%), giving a reddish to red-brownish solution at pH of 4.00–7.00. The addition of antioxidant significantly (p = 0.000) enhanced the stability of the extract in an accelerated stability test (90.34 ± 5.32 from 67.83 ± 3.45% TAC remaining). Three base hair gels containing different thickeners were developed to yield clear gels with a viscosity of 101,666.67–447,333.33 cps and a pH of 4.80–4.97. The gel base with the best hair application properties was chosen to mix with 8, 10 and 12% black bean extract to produce similar visually assessed red-brown gels (L* = 33.25–33.76, a* = 0.06–0.09, b* = − 0.45–0.38 and h* = 277.54–283.31) at 73,733.33–99,666.67 cps and a pH of 5.00–5.01. All of the black bean hair coloring gels were stable under the accelerated test. The 10% hair gel was tested for its hair staining efficacy. The black bean hair coloring gel was found to efficiently color hair, and the color was maintained through four washings.

Conclusions

An alternative application approach of using black bean as a natural colorant is presented here, including its basic requirements for preparation and quality control from an industrial aspect. The efficient semi-permanent hair coloring product containing black bean is an innovative natural product and is considered as one progress towards a sustainable bio-based economy using a readily available industrial crop, black bean.
Herbal medicines: a cross-sectional study to evaluate the prevalence and predictors of use among Jordanian adults
Authors: El-Dahiyat Faris , Rashrash Mohamed , Abuhamdah Sawsan , Abu Farha Rana , Babar Zaheer-Ud-Din
Published: January 2020

Introduction

Understanding why adults resort to herbal medicine can help in planning interventions aimed at increasing awareness regarding herbal use. This study sought to investigate the prevalence and to determine factors for predicting the use of herbal medicine among Jordanian adults.

Methods

A cross-sectional study was conducted involving 378 older adults who were randomly selected from two different areas of Jordan. A questionnaire was used to gather data and validation criteria for validity and reliability of the content were tested by content and face validity in a panel of experts.

Results

From a total of 500 invited participants, 378 completed the questionnaire. The prevalence of the use of of herbal products in this study was high at 80.2%. Herbal medicines use was not associated with any demographic factors other than age (p < 0.05). Moreover, the only associated health-related characteristic was the patient’s disease state including, notably, hypertension (p < 0.05). Reasons for not using herbal medicines as reported by nonusers included mainly a lack of belief in their efficacy (52.2%). Another two important reasons were that the individuals believed themselves to healthy and have no need for their use (31.3%) and the unavailability of enough information about the herbal medicines (29.7%). Finally, the most common side effects as reported by patients in this study were nausea and vomiting (9.3%), and, to a lesser extent, skin rash (2.1%).

Conclusion

There is a high rate of use of herbal medicines in Jordan, especially among hypertensive patients. Therefore, there is a need to establish effective herbal medicine policies and health education programs to discuss the benefits and risks of herbal medicine use, with the aim of maximizing patient-desired therapeutic outcomes.
Correction to: A case of intracoronary and endovenous levosimendan as a rescue therapy for refractory cardiac arrest
Authors: Ferro B. , Tofani R. , Vegnuti L. , Borelli G. , Gargani L. , Roncucci P.
Published: January 2020

After publication of this supplement [1], it was brought to our attention that the author ‘L. Vegnuti’ has been erroneously omitted from the author list of the following abstract.
Recent Applications of Amorphous Alloys to Design Skeletal Catalysts
Authors: Salinas-Torres David , Nozaki Ai , Navlani-García Miriam , Kuwahara Yasutaka , Mori Kohsuke , Yamashita Hiromi
Published: January 2020

Amorphous alloys are still attracting great attention in the field of catalysis despite the fact that they have been investigated since the 1950s. One of the reasons why amorphous alloys have been in the spotlight until now, are their physical and chemical properties, which would make them suitable materials to be used as catalysts at industrial scale. This review deals with the recent research on applications of amorphous alloys for catalysis. These investigations were addressed to elucidate the relationship between the structural changes (morphology, surface-exposed metal sites, etc.) and the catalytic activity for representative reactions such as hydrogenations, oxidations and hydrogen production from hydrogen carrier molecules. Furthermore, the impact of the combination of an amorphous alloy with another kind of material (MOF and CeO2) and the introduction of a third metal was also discussed.
Introduction of Professional Standards in the Organization Human Resources Management System
Authors: Zaharov D. , Kashtanova YEkatyerina
Published: January 2020

This article discusses the implementation of professional standards in an organization. The author studies the prerequisites for the implementation of professional standards, the legislative framework to be followed, the methodological steps and the results of implementation. It is described that the implementation of professional standards in the organization requires the following steps: determining the list of posts, familiarizing employees, analyzing internal documents (labor contracts, job descriptions), posting information on a corporate website, creating personal training programs, conducting qualifi cation assessments and adjusting programs advanced training of employees. One of the results of the implementation of professional standards is the improvement of the quality of knowledge, skills and abilities of employees, as well as their eff ective placement in the organization. In addition, the article systematizes a plan for further work with professional standards.
Ant (Hymenoptera: Formicidae) diversity in savanna ecosystem: a comparison of sampling methods and seasons

Authors: MAGAGULA CEBISILE N.
Published: January 2020

One of the most important means of obtaining biodiversity information in natural ecosystems is surveying and collection of biological specimen using appropriate sampling methods. This study was carried out to determine the most appropriate sampling method for ants in a savanna ecosystem during two distinct seasons. Pitfall trapping, direct search and litter extrac­tion produced significantly different species lists, with each method having unique species and seasons also showed the same trend. A total of 53 species were collected from both conservation areas during the study, with Pheidole sp.4, Crematogaster amita and Monomorium albopilosum being the three most dominant species. Generalised Myrmicinae and opportunists were the functional groups with the highest species richness in all methods and seasons, with pitfall trapping having the highest richness. While pitfall trapping and direct search were deemed to be the most efficient methods in this savanna, results also suggest that varied sampling methods are necessary to ensure sampling of all microhabitats within a specific locality. Ad­ditionally, utilisation and testing of sampling methods is essential for each geographic region.Key words: Sampling, biodiversity assessment, species list, insects, Formicidae, ants, savanna
Effect of GNAQ alteration on RANKL-induced osteoclastogenesis in human non-small-cell lung cancer
Authors: Choi Ji-Yoon , Lee Yun Sun , Shim Da Mi , Seo Sung Wook
Published: January 2020

Aims

Receptor activator of nuclear factor-κB ligand (RANKL) is a key molecule that is expressed in bone stromal cells and is associated with metastasis and poor prognosis in many cancers. However, cancer cells that directly express RANKL have yet to be unveiled. The current study sought to evaluate how a single subunit of G protein, guanine nucleotide-binding protein G(q) subunit alpha (GNAQ), transforms cancer cells into RANKL-expressing cancer cells.

Methods

We investigated the specific role of GNAQ using GNAQ wild-type cell lines (non-small-cell lung cancer cell lines; A549 cell lines), GNAQ knockdown cell lines, and patient-derived cancer cells. We evaluated GNAQ, RANKL, macrophage colony-stimulating factor (M-CSF), nuclear transcription factor-κB (NF-κB), inhibitor of NF-κB (IκB), and protein kinase B (Akt) signalling in the GNAQ wild-type and the GNAQ-knockdown cells. Osteoclastogenesis was also evaluated in both cell lines.

Results

In the GNAQ-knockdown cells, RANKL expression was significantly upregulated (p < 0.001). The expression levels of M-CSF were also significantly increased in the GNAQ-knockdown cells compared with control cells (p < 0.001). GNAQ knockdown cells were highly sensitive to tumour necrosis factor alpha (TNF-α) and showed significant activation of the NF-κB pathway. The expression levels of RANKL were markedly increased in GNAQ mutant compared with GNAQ wild-type in patient-derived tumour tissues.

Conclusion

The present study reveals that the alterations of GNAQ activate NF-κB pathway in cancers, which increase RANKL and M-CSF expression and induce osteoclastogenesis in cancers. Cite this article: Bone Joint Res. 2020;9(1):29–35.
Maria Dolors Orriols, (auto)traductora [CAT.]
Authors: Bacardí Montserrat
Published: January 2020

Maria Dolors Orriols (1914-2008) forma part de la primera generacióde novel·listes de la postguerra, al costat de Maria AurèliaCapmany, Teresa Pàmies o Cèlia Suñol, que sovint van donar aconèixer les seves obres tardanament. En tots els casos, les circumstànciesvitals van influir poderosament en les seves creacionsi, com ha estat assenyalat, van conrear una narrativa de base autobiogràfica.La reelaboració de l’escriptura pròpia és a l’origend’algunes autotraduccions d’Orriols, mentre que en altres s’intueixun desig de traspassar fronteres a la recerca de nous lectors. Delfrancès al català va traduir textos inquietants i subversors deFranz Kafka (a la revista Aplec, que ella va editar), o de GeorgesBernanos, a part de fragments del Kalevala. Gairebé totes les sevestraduccions i autotraduccions romanen inèdites.
EL ENFOQUE FEMINISTA DE LA TRADUCCIÓN E INTERPRETACIÓN: UNA VENTAJA COMPETITIVA
Authors: Reimóndez María
Published: January 2020

Tradicionalmente, la investigación nos ha presentado la práctica de latraducción feminista como un espacio de conflicto, algo que no animaa jóvenes profesionales a trabajar desde esta perspectiva ética. Si bienes cierto que un enfoque feminista ante la vida implica un cierto nivelde oposición y conflicto, también es cierto que la parte positiva de seruna traductora feminista no ha sido estudiada y por lo tanto permaneceinvisible. Este artículo se centra en las ventajas de ser traductorae intérprete feminista en el mercado y cómo este enfoque es fundamentalpara una labor realmente profesional.
EL UNIVERSO EDUCATIVO DE IDA BACCINI: PASIÓN, COMPROMISO Y PERSONALIDAD
Authors: Bartolotta Salvatore , Giordano Paredes María Angélica
Published: January 2020

La obra y la personalidad de Ida Baccini se funden en un universo variopinto de ideas, instrucción y reclamos innovadores, en un marco sociopolítico liderado por cambios e importantes reformas. En ese momento de transición histórica, la nueva Italia unida, necesitaba un modelo de sociedad cuya ejemplaridad creara los pilares de una nación fuerte e instruida. A esa llamada acude la maestra, escritora, periodista e inquieta idealista para marcar los inicios de una buena formación académica y dejar su huella, totalmente innovadora, en los manuales escolares y en sus cuentos infantiles y juveniles que contribuirían enormemente al desarrollo de la educación italiana; aunque, lamentablemente, se haya quedado en el olvido y sus obras no tengan eco más allá de las fronteras. A este rescate contribuiremos en el presente artículo.
HE AQUÍ LA VIDA DE UNA MUJER LITERATA.1 TRADUCCIÓN Y GÉNERO EN LAS POLÍTICAS EDITORIALES EN GALICIA (2011-2018)
Authors: Buján Otero Patricia
Published: January 2020

A partir del análisis del catálogo de traducciones escritas porautoras y publicadas en gallego entre 2011 y 2018, y ante lasperspectivas que permite vislumbrar el panorama editorial reciente,queremos observar si se está produciendo una ruptura del estado de triple marginalidad (traducción, género y lengua) al quese ven sometidas en el sistema literario gallego las publicacionesde traducciones al gallego de obras originales escritas por mujeres.
TRADUCCIONES ESPAÑOLAS DE LA OBRA DE ANNA DE NOAILLES
Authors: Lafarga Francisco
Published: January 2020

Este trabajo, que pretende contribuir a un mejor conocimiento dela recepción española de escritoras francesas del rico periodoliterario del fin de siglo y el primer tercio del siglo XX, se centra enla figura de Anna de Noailles (1876-1933, de soltera Anna BibescoBassarava de Brancovan). Tras poner de manifiesto el papel degran figura social y literaria que jugó en la Francia de su tiempo,se pasa al estudio de su recepción en España, básicamente graciasa testimonios en la prensa de la época, y se insiste en particular enlas traducciones de su obra, gran parte de ellas diseminadas enprensa y en antologías, aunque también en forma de libro, debidasprincipalmente a Tomás Borrás (1931), Rosa Chacel (1948) y MiriamAlonso Ribeiro (2011).
LA CORRESPONDENCIA EN FEMENINO DE GEORGE SAND: LA MARCA DEL GÉNERO GRAMATICAL EN LA TRADUCCIÓN DEL FRANCÉS AL ESPAÑOL
Authors: Maturana García Andrea
Published: January 2020

La traducción al español de la correspondencia de George Sand,una escritora con una identidad andrógina que oscila entre elgénero masculino y femenino, presenta las problemáticas de unlenguaje sexista y excluyente. El problema traductológico surgecuando esta mujer, próxima al género masculino a fin de obtenersu lugar en el mundo literario, muestra su cambio de identidad nosolo en sus acciones y su vestimenta, sino también en su lenguaje.Ahora bien, contrariamente a lo que André Maurois asegura al decirque, desde el día en que Aurore Dudevant se convirtió enGeorge Sand, “empezó a utilizar el masculino en todos los adjetivosque se referían a ella” (1952: 147), su correspondencia demuestracómo hace uso alterno del masculino y del femenino parareferirse a su persona. Tratando de mantenerme fiel a laalternancia e incluso a la ausencia de género en francés medianteel uso de sustantivos epicenos y de construcciones parafrásticasen español, esta traducción demuestra las limitaciones dellenguaje a la hora de representar la alternancia entre ambosgéneros y la ausencia de un género específico.
LA EVOLUCIÓN DE LA IMAGEN DE LA MUJER EN EL CÓMIC ITALIANO Y SU RECEPCIÓN EN ESPAÑA
Authors: Romano Martín Yolanda
Published: January 2020

Este trabajo pretende mostrar una panorámica de los personajes femeninos de las viñetas italianas que se han conocido en España. Desde sus inicios, la historia del cómic italiano nos ha ofrecido una gran variedad de mujeres de todas las edades y en roles diversos: desde la heroína, la villana, el ama de casa pasando por la damisela inocente, la radical feminista o la bomba sexy. Muchos son los arquetipos que conforman una gran gama de estereotipos femeninos en el mundo del cómic y cada uno de ellos encuentra su explicación en los fundamentos sociológicos y de análisis de la cultura de masas. Veremos de qué manera han ido apareciendo en España y cómo ha sido su recepción entre la crítica y los lectores.
LA FEMINIZACIÓN DEL EJERCICIO PROFESIONAL DE LA TRADUCCIÓN EDITORIAL: ENTRE LA PRECARIEDAD Y EL ENTUSIASMO
Authors: Francí Ventosa Carmen
Published: January 2020

Por causas diversas, en el mundo editorial español se estáproduciendo una feminización progresiva de la profesión detraductor literario. Analizados los datos por franjas de edad, seobserva que en breve será mucho mayor la proporción detraductoras que la de traductores. En este sentido cabe preguntarsesi esta feminización va acompañada de algún tipo de techode cristal en relación con el prestigio de las obras traducidas, lastarifas o los ingresos. Y si, como resultado de lo dicho, lastraductoras se ven sujetas a la doble invisibilidad derivada de lacondición femenina y la inherente a una profesión consideradasubalterna.
PRESENTACIÓN. “BEING A TRANSLATED BEING”: MUJER Y TRADUCCIÓN
Authors: Camps Assumpta
Published: January 2020

TRADUCIR EN FEMENINO: PRÁCTICAS TEXTUALES Y POLÍTICAS Edición de Assumpta Camps; Laura Carlucci; Daniele Cerrato; Ana Luna; Áurea Fernández Isabel Serra
How many photons are needed for FRET imaging?
Authors: Esposito Alessandro
Published: January 2020

Förster resonance energy transfer (FRET) imaging is an essential analytical method in biomedical research. The limited photon-budget experimentally available, however, imposes compromises between spatiotemporal and biochemical resolutions, photodamage and phototoxicity. The study of photon-statistics in biochemical imaging is thus important in guiding the efficient design of instrumentation and assays. Here, we show a comparative analysis of photon-statistics in FRET imaging demonstrating how the precision of FRET imaging varies vastly with imaging parameters. Therefore, we provide analytical and numerical tools for assay optimization. Fluorescence lifetime imaging microscopy (FLIM) is a very robust technique with excellent photon-efficiencies. However, we show that also intensity-based FRET imaging can reach high precision by utilizing information from both donor and acceptor fluorophores.
Modulating trap properties by Nd3+- Eu3+ co-doping in Sr2SnO4 host for optical information storage
Authors: Wang Caiyan , Zheng Zhehan , Zhang Ying , Liu Qian , Deng Mingxue , Xu Xiaoke , Zhou Zhenzhen , He Huan
Published: January 2020

We report a novel Nd3+ and Eu3+ co-doped Sr2SnO4 (SSONE) phosphor showing the capability of “write-in” and “read-out” in optical information storage. As-prepared phosphors exhibit a dominant emission (PL) band centered at 596 nm under UV excitation, closely identical with its photo-stimulated luminescence (PSL) spectrum center (595 nm) upon near-infrared (NIR) light and thermal-stimulated luminescence (TSL) spectrum center (595 nm) under heat source. Remarkably, compared with Eu3+ single-doped phosphors, the co-doping strategy enhances the deep traps and also separates the deep traps with shallow traps, which are very crucial factors for optical information storage in electron trapping materials. Further, a demonstration confirmed the optical information storage capacity by photo- and thermal-stimulating the prepared phosphors filled in the designed patterns.
Sub-Nyquist computational ghost imaging with deep learning
Authors: Wu Heng , Wang Ruizhou , Zhao Genping , Xiao Huapan , Wang Daodang , Liang Jian , Tian Xiaobo , Cheng Lianglun , Zhang Xianmin
Published: January 2020

We propose a deep learning computational ghost imaging (CGI) scheme to achieve sub-Nyquist and high-quality image reconstruction. Unlike the second-order-correlation CGI and compressive-sensing CGI, which use lots of illumination patterns and a one-dimensional (1-D) light intensity sequence (LIS) for image reconstruction, a deep neural network (DAttNet) is proposed to restore the target image only using the 1-D LIS. The DAttNet is trained with simulation data and retrieves the target image from experimental data. The experimental results indicate that the proposed scheme can provide high-quality images with a sub-Nyquist sampling ratio and performs better than the conventional and compressive-sensing CGI methods in sub-Nyquist sampling ratio conditions (e.g., 5.45%). The proposed scheme has potential practical applications in underwater, real-time and dynamic CGI.
Silicon microparticles as handles for optical tweezers experiments
Authors: Moura T. A. , Andrade U. M. S. , Mendes J. B. S. , Rocha M. S.
Published: January 2020

We study the behavior of silicon microparticles in a 1064 nm Gaussian-beam optical tweezers, showing that this semiconductor can be used to perform different types of optical manipulation experiments. Depending on the focal position and the laser power used, the particles can present an oscillatory dynamics in the tweezers or can be stably 3D-trapped with a trap stiffness that allows the application of femtoNewton forces with accuracy. A new, to the best of our knowledge, interpretation based on the photoexcitation of electrons in the valence band is proposed to explain the oscillations, and the quantities associated with such dynamics (e.g., amplitude, period, etc.) were characterized as a function of relevant parameters to optical tweezers setups.
Infrared photodetector based on GeTe nanofilms with high performance
Authors: Zhao Yiqun , Tang Libin , Yang Shengyi , Seng Teng Kar , Ping Lau Shu
Published: January 2020

GeTe is an important narrow band gap semiconductor material, which has found application in the fields of thermoelectricity, phase change storage as well as switch. However, it has not been studied for application in the field of photodetectors. Here, GeTe thin films were grown by magnetron sputtering and their material structure, optical and electrical properties were compared before and after annealing. High-performance photodetectors with detectivity of

∼

10

13

Jones at 850 nm light were demonstrated. Thus the novel, to the best of our knowledge, application of GeTe in optoelectronic devices is reported in this work.
High-resolution, large-dynamic-range multimode interferometer sensor based on a suspended-core microstructured optical fiber
Authors: Zheng Yu , Shum Perry Ping , Luo Yiyang , Zhang Yanan , Ni Wenjun , Wang Guanghui , Wu Zhifang , Dinh Xuan Quyen , Auguste Jean-Louis , Humbert Georges
Published: January 2020

The performance of sensors, including optical fiber sensors, is commonly limited by the tradeoff between a large dynamic range and a high resolution. In this Letter, in order to optimize both, we propose an inline multimode interferometer sensor based on a suspended-core microstructured optical fiber. Due to the existence of multiple pairs of mode interferences, the transmission spectrum of the interferometer consists of dense fringes modulated by a lower envelope. Since these mode interferences take place in the uniform material with the same length, the dense fringes and the lower envelope have an identical sensing response without crosstalk. Hence, the sensor integrates the large dynamic range of the lower envelope and the high resolution of the dense fringes. Strain-sensing performance is investigated to validate the characteristic of the large dynamic range and the high resolution of the proposed sensor. The dynamic range, theoretically 0–9200 µɛ, is 12 times larger than for the dense fringes, and the resolution is 17.5 times higher than for the lower envelope.