bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Economic Growth on Environmental Health: Evidence from Argentina, Equatorial Guinea, and South Korea
Authors: Akbar Ume Salma
Published: January 2024

This study investigates the influence of economic growth on CO2 emissions levels in three developed countries—Argentina, Equatorial Guinea, and South Korea—based on their status as high-income countries. We test the environmental Kuznets curve (EKC) hypothesis using the time series approaches to check the relationship and direction of causality among the variables over a sample spanning 1974–2020. The results show an inverted U-shaped short-run relationship in all three countries. In the long run, only South Korea supports the EKC hypothesis. Further, Granger causality results indicate the existence of causality. These long-run causal relationships between economic growth and emissions recommend one policy implication that wealthy governments must expand investments in renewable clean energy projects and R&D, with regulatory measures to suppress harmful environmental procedures and support environmentally friendly development.
When Luxury Brands Live Streaming to the Consumers With or Without Purchase Experience! The Role of Servicescape, consumer trust and Perceived value of luxury
Authors: Yu Jun-Ying , Gao Jing , Guo Jia-Rui
Published: January 2024

This study examines the influences of live streaming servicescape on Chinese consumers' luxury purchase intention. Interestingly, for the sample without luxury purchase experience, the mediating effect of the perceived value of luxury goods is significant but effect of consumer trust is not. For the sample with luxury purchase experience, the result of mediating effect is just the opposite. The interaction between conspicuous consumption and live streaming servicescape plays a certain role in regulating the perceived value of luxury goods. These results show that luxury brands can adopt innovation in the live streaming servicescape for different types of consumers to promote live streaming marketing. This study enriches the servicescape theory of live streaming.
Family characteristics and income: Evidence from Indonesia
Authors: Firdaus Husban Yarjuna , Satrio Aham Bagas , Fahrudin Muhammad Safli , Siregar Muhammad Adam
Published: January 2024

Balance in the form of linkages between socioeconomic aspects of a region is the key to economic stability. This economic stability is essential to achieve community welfare, so existing interventions must be considered considering that  a slight change in one aspect will affect the economic balance. With the achievement of community welfare, the economic development of a region can be said to be good, which also has implications for handling existing socioeconomic problems. However, the misalignment of education level, gender, internet access, and marital status of each district/city area triggers differences in income levels. Therefore, through this study, it is expected to be able to answer whether factors such as education level, gender, internet access, and marital status are factors that influence the magnitude of income levels, especially in DIY Provinces. By using IFLS-5 data processed through an estimat ion method using logistic regression, test results were obtained that gender and internet access factors significantly affected the amount of people's income. In contrast, the level of education and marital status did not significantly affect the income of people in DIY Province
The influence of brand image on purchase intention in social commerce TikTok Shop: The role of trust
Authors: Saktiawan Bimo , Permatasari Harnung Indah , Wulandari Trisninik Ratih
Published: January 2024

People are starting to change their habits, especially after the Covid-19 pandemic, which made them prefer shopping online. Many online shopping platforms can be used by consumers, including social media as well as e-commerce or the social commerce term TikTok Shop. The TikTok application has great potential in the e-commerce sector, including the marketing industry and online shopping media in the form of short videos. On the other hand, TikTok can provide a positive value to the brand image of a product. If the product has a positive brand image, the impact will be that people will trust and know the product well. Besides the brand image, consumer purchase intention is also based on trust. The problem is consumer trust in TikTok as a social media-based online shopping tool is still being debated. This study aims to prove the effect of brand image mediated by customer trust on purchase intention in the social commerce TikTok Shop. This research method is quantitative, and the data used is primary data from an online survey via LimeSurvey. The total number of respondents is 333 people who are spread throughout Indonesia. Next, the collected data was analyzed by SEM on SmartPLS. The results of the study show that brand image has a significant effect on customer trust and purchase intention.
Menanam Asa Kepedulian Lingkungan Pengabdian Masyarakat Desa Penatar Sewu
Authors: Faizah Ima
Published: January 2024

Puji syukur kehadirat Allah SWT yang telah melimpahkan rahmat dan hidayah-Nya sehingga kami dapat menyelesaikan tugas kami sebagai mahasiswa dalam rangka pengamalan salah satu catur dharma perguruan tinggi yaitu pengabdian masyarakat. Pengabdian masyarakat yang kami laksanakan berada di Desa Penatarsewu, Kecamatan Tanggulangin, Kabupaten Sidoarjo.
20 Hari Merintis Pengabdian di Desa Trompoasri Dusun Janganasem Tahun 2019
Authors: Untari Rahmania Sri
Published: January 2024

Puji syukur senantiasa kami panjatkan kehadirat Tuhan Yang Maha Esa yang telah memberikan rahmat dan hidayah-Nya sehingga penulis dapat melaksanakan kegiatan dan menyelesaikan buku Kuliah Kerja Nyata Terpadu Universitas Muhammadiyah Sidoarjo (KKN-T UMSIDA) yang berjudul “20 Hari Merintis Pengabdian di Dusun Janganasem Desa Trompoasri”.
Neoadjuvant Immunotherapy combined with Chemoradiotherapy VS. Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma(cStageII-III): Study Protocol For A Multi-center Prospective Randomized Clinical Trial
Authors: Huang Xu , Tang Han , Jiao Heng , Yin Jun , Wang Hao , Xu Wenyi , Yin Hao , Yang Shuyi , Wang Qingle , Zeng Mengsu , Jiang Dongxian , Hou Yingyong , Du Shisuo , Zeng Zhaochong , Li Yin , Chen Keneng , Li Zhigang , Han Yongtao , Shen Weiyu , Chen Qixun , Jiang Hongjing , Fan Hong , Jiang Bo , Liao Yongde , Tan Lijie
Published: January 2024

Background
Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been suggested as the standard treatment for locally advanced ESCC. Meanwhile, CHECKMATE-577 has suggested that immunotherapy may be effective in controlling tumor recurrence and metastasis. According to PALACE-1, Neoadjuvant radiotherapy and chemotherapy combined with immunity may be more beneficial for patients. Therefore, it is meaningful to further study whether the combination of nCRT and immunotherapy has better effects in the treatment of ESCC.
Methods
NCT04973306 is designed as a multicenter, prospective, randomized, Phase II/Phase III clinical trial discussion, investigating the safety and efficacy of nCRT plus tumor immunotherapycompared with nCRT. A total of 476 patients with locally advanced resectable ESCC (stage cII-III) are randomly assigned to neoadjuvant immunotherapy combined with chemoradiotherapy (arm A) or nCRT (arm B) with a 1:1 allocation ratio. The primary endpoint of the first phase of the study was pCR. Overall survival assessed with a minimum follow-up of 36 months served as the study's main goal during the second phase (OS). Secondary outcomes are R0 resection rate, positive lymph node rate and response, number of lymph nodes cleared, tumor regression grade (TRG) of primary tumor, and disease-free survival (DFS) between the two groups
Discussion
This trial aims to study whether nCRT plus tumor immunotherapy yields superior benefits for curative treatment of ESCC and the survival. Trial registration number is NCT04973306.
Early warnings of bee colony failure
Authors: Colin Théotime , Dakos Vasilis , Barron Andrew , Meikle William , Altmann Eduardo , Latty Tanya
Published: January 2024

How to identify ecological systems at risk of failure is a central question of modern biology and agriculture. Due to human impacts and global change, there is a growing need for early warning signals that identify when an ecological system is at risk of a state change before those changes become irreversible or extremely complex and costly to remediate. Honeybees (Apis mellifera) are an urgent case because our food crops heavily rely on them for pollination and annual bee colony losses reported by beekeepers across the globe are unsustainable. Given enough warning, beekeepers can rescue dying colonies, but early warning signals of death for individual bee colonies are lacking. Here we used early warning signals to investigate whether fluctuations and dynamical patterns in internal hive temperature can be used as an early indicator of impending colony failure. Across three distinct datasets we found that temperature regulation of failing colonies was different enough to distinguish them from healthy colonies weeks before they died. This signal comes early enough to intervene and assist colonies with standard beekeeping practices. Our study shows that early warning theory can help to identify practical signals of risk of state change even in systems that change state relatively rapidly, such as a dying bee colony, early enough to intervene and prevent losses.
A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation.
Authors: Wyneken Ursula , Yantén-Fuentes Liliana , Pizarro Matías , Rojas Carolina , Pradenas Carolina , Corvalán Katherine , Bustos Gonzalo , Luarte Alejandro , Batiz Federico , Luz-Crawford Patricia , Pino-Lagos Karina
Published: January 2024

The connection between stress-induced mood disorders and inflammatory bowel diseases has long been acknowledged. Here, we hypothesize that psychological stress may regulate intestinal inflammation under stress conditions through the release of small extracellular vesicles derived from astrocytes (AsEVs). Sprague-Dawley rats were stressed by movement restriction. In-utero electroporation was performed to express a recombinant protein (BAP-TM) in astrocytes that is exported in AsEVs. AsEVs were also obtained from primary astrocyte cultures that were stimulated with DMSO or corticosterone (to emulate a stress condition). The inflammatory status in the blood and intestine was assessed by flow cytometry and histology, respectively. We found that recombinant AsEV proteins expressed in brain astrocytes as well as AsEVs harvested from primary astrocyte cultures contain the gut homing receptor CCR9 and target the small intestine in rats. At the histological level, inflammatory parameters (such as lymph vessel diameter or cell number in them) induced by movement restriction are restored to normal levels by treatment with AsEVs derived from primary astrocytes. On the contrary, AsEVs derived from corticosterone-treated astrocytes increase stress-induced intestinal inflammation. Furthermore, AsEVs can modulate the immune balance of the GALT: while AsEVs derived from control astrocyte cultures favor an anti-inflammatory profile (i.e., increased Treg/Th17 ratio), AsEVs derived from corticosterone-treated astrocytes have an opposite action. We here reveal an entirely new brain-to-gut AsEVs-mediated communication pathway that may impact on stress-induced inflammatory bowel pathophysiology. This research paves the way for novel, cutting-edge therapeutic approaches to tackle the complex interplay between stress and intestinal inflammatory diseases.
Nonlinear resonant responses of suspended cables with a longitudinal time-delayed feedback control
Authors: Peng Jian , Li Luxin , Hu Xia , Xie Xianzhong , Lenci Stefano
Published: January 2024

In this study, the vibration control of suspended cables is achieved through the implementation of a longitudinal time delay feedback control strategy. Based on the Hamiltonian variational principle and using boundary conditions, the motion differential equations for the suspension cable under longitudinal time-delayed feedback control are derived. The delay differential equations are discretized using the Galerkin method. The fourth-order approximate solution for the primary resonance response of the suspension cable under time-delayed feedback control is obtained using the method of multiple scales. The correlation between the system response and the controlled parameters is established, and the vibration control effects under different control parameters are analyzed through numerical examples.
From Tradition to Innovation: IoT-Enabled Precision Farming Strategies for Optimal Resource Use efficiency in Tomato Crop Management
Authors: Kaliannan Nirmal , Sabapathi Naveen Latha , Ranjan Sushant , Prabhakar Varun , Salimath Mahesh
Published: January 2024

This study investigates the response of two varieties of plants, Sahoo and SVTD8323, to different fertilizer treatments. The Sahoo variety showed a quick response to the fertilizer treatments, with F1 and F2 treatments resulting in a 17% and 26% increase in plant height at 40 DAT, respectively. Both varieties showed an increase in the number of branches, with F2 treatment resulting in a 24% and 26% increase in Sahoo and SVTD8323, respectively. Both the varieties showed an increase in fruit weight, with Sahoo showing a 5.8% and 7.9% increase in fruit weight over the control at F1 and F2 treatment, respectively, while SVTD8323 showed a 2.9% and 5.5% increase in fruit weight over the control at F1 and F2 treatment, respectively. Both varieties followed a parabolic curve in yield per harvest across treatments, with Sahoo showing a 12.5% increase in yield at F1 treatment and a 13.5% increase at F2 treatment over the control treatment. Similarly, SVTD8323 showed a 12.5% increase in yield at F2 treatment over the control treatment. In a nutshell both the varieties consumed 29 to 39% lesser water and 25% lesser fertilizer than respective control treatment. The benefit to cost ratio was highest at F2 treatment in both varieties, with a ratio of 2.14 in Sahoo and 2.27 in SVTD8323, indicating that the IoT enabled precision farming profitable.
Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
Authors: Monistrol-Mula Anna , Diaz-Torres Santiago , Felez-Nobrega Mireia , Haro Josep Maria , Medland Sarah , Mitchell Brittany
Published: January 2024

Current literature suggests that people with psychiatric disorders have higher risk of SARS-CoV-2 infection and a worse prognosis of the disease. We aimed to study the genetic contribution to these associations in a range of psychiatric disorders and COVID-19, and determine whether these are unique or shared across psychiatric disorders. Using the largest available genome-wide association studies, we analysed the genetic overlap between six psychiatric disorders and COVID-19. We further identified specific regions of the genome that are shared across the psychiatric disorders and COVID-19 using pairwise GWAS, and examined which genes are present in these regions. Finally, we sought evidence for causal associations using Mendelian Randomization methods. We found a significant genetic overlap between depression and ADHD, with both COVID-19 susceptibility and severity, as well as between anxiety and COVID-19 severity. We identified specific regions of the genome shared between several psychiatric disorders and COVID-19. However, no region was common across all psychiatric disorders and COVID-19. Gene-based analysis in these genomic regions suggested possible links with immune-related pathways such as thyroid homeostasis, inflammation and stress response. Finally, we provide evidence of a potential causal relationship between ADHD and higher COVID-19 susceptibility and severity, and between depression and higher susceptibility to COVID-19. Our results support the hypothesis that the relationship between psychiatric disorders and COVID-19 risk is likely due to shared alterations in immune-related pathways and are not as a result of environmental factors alone, shedding light on potentially viable therapeutic targets.
Developing the 10-year Persian Adult Hypertension Risk Score (PAHRS) Based on Yazd YHHC Healthy Heart Cohort (YHHC) Study: A Longitudinal Study on 20-74 Year-Old Population of Yazd
Authors: Namayandeh Seyedeh Mahdieh , MohammadiMoghaddam Hossein , Fallahzadeh Hossein , Majidpoure Fatemeh , Soltani Mohammadhosein , SadrBafghi Seyed Mahmood , Ghomi Farnoosh
Published: January 2024

Introduction
Hypertension is major risk factor for cardiovascular and renal diseases and has become one of the major global challenges.To Development of a 10-year Persian Adult Hypertension Risk Score (PAHRS) based on Yazd healthy heart cohort study data. The present study is a longitudinal study as a sub study of Yazd Healthy Heart Cohort (YHHC).
Method
A total number of 1152 out of 2000 participants aged 20–74 years without hypertension at baseline were included in this study. The risk scoring system was used to predict the incidence of hypertension over a ten-year follow-up using logistic regression model. The performance of the predictive algorithm was evaluated using calibration and model discrimination. A web application was developed based on this study result and risk assessment system with link of https://survey.porsline.ir/s/2OGlwx6H.
Result
A total number of 324 patients (36.3%, mean age of 42.8 years) became hypertensive at the end of the 10-year follow up of the present study. In the multivariate logistic regression model, age, family history of hypertension, baseline systolic hypertension, history of diabetes, hyperglycemia, and obesity were identified as independent predictors of hypertension. Participants according to their ten-years hypertension risk by the point score system classified into three groups: low-risk, with a risk of < 10% in 135 participant (11.7%) and intermediate-risk,with a mean risk of 10% -20% in 319 participant (27.7%) and high-risk with a risk of > 20% in 698 participant(60.6% ). The value of C statistic for the point score system was calculated to be 0.72 and the Hosmer-Lemeshow test for the calibration was acceptable (χ2 = 3.26, P = 0.917) for ten years of incidence of hypertension in the YHHC study.
Conclusion
The Persian Adult Hypertension Risk Score (PAHRS), which was developed for the first time using Yazd native residents' data, is a simple and useful tool in hypertension risk assessment and consider prevention program based on high risk population approach.. The almost two third of the our study population was estimated to be at high risk for hypertension during ten years so using our risk scoring system can be used for health policy in primary prevention of hypertension in communities.
Evaluation of the effect of the Azadirachta indica (Margosa) leaf syrup on the control of the caterpillar in cabbage in the community of Phandira, Dunda, District of Macossa in Republic of Mozambique.
Authors: Parwez Zahid , Joaquim Boneze Nhampoca Jaime
Published: January 2024

A descriptive experimental study was carried out to have a bird eye view on the effect of the syrup made from leaves of Azadirachta (Margosa) indica A. Juss (Neem) on the control of the caterpillar (Trichoplusia ni) in cabbage seedlings, and the plot method was applied to the samples of 250 seedlings. The trial was carried out between January and May 2022 and a completely casualized block design (DBCC) was used, with 4 treatments, making a total of 15 experimental units (plots). The area was divided into 3 randomized blocks and each block with 5 plots where the sowing was carried out in lines with a 15 cm compass between lines in the same plot and the seeds were released within each line, without having a space between the seeds within the lines once dealing with a nest. Three parameters were evaluated, Population density, Infestation level and Medium attack level. The collected data were submitted to statistical processing using (SISVAR 5.6) and analysis of variance and Tukey's test at 5% of significance, however, significant differences were found for the parameters degree of infestation (GI) and number of caterpillars (NL) related to the percentage of caterpillar mortality when submitted to different doses of Neem extract application.
A bilateral four-headed brachialis muscle with variant innervation: a cadaveric report with possible clinical implications
Authors: PIAGKOU MARIA , Triantafyllou George , Koutsougeras Aggelos , Koutserimpas Christos , Katsogiannis Dimitris , Georgiev Georgi , Olewnik Lukasz , Zielinska Nicol , Tsakotos George
Published: January 2024

Purpose: Anterior compartment muscles of the arm present high morphological variability, with possible clinical significance. The current cadaveric report aims to describe a bilateral four-headed brachialis muscle (BM) with aberrant innervation. Analysis of the embryological background and possible clinical significance of the BM variant is also provided.
Methods: Classical dissection of the upper limb was performed on an 84-year-old donated male cadaver. The cadaver belonged to the Anatomy Department of the National and Kapodistrian University of Athens.
Results: On the left upper limb, the four-headed BM was supplied by the musculocutaneous and the median nerves after their interconnection. On the right upper limb, the four-headed BM received its innervation from the median nerve due to the musculocutaneous nerve absence. A bilateral muscular tunnel for the radial nerve passage was identified, between the BM accessory heads and the brachioradialis muscle.
Conclusion: BM has clinical significance, due to its proximity to important neurovascular structures and frequent surgeries at the humerus. Hence, knowledge of these variants should keep orthopedic surgeons alert when intervening in this area.
Determination of Perfluorinated Substances (Pfas) in Certain Foodstuffs According to Newly Established Eu Legislation
Authors: Pasecnaja Elina , Zacs Dzintars
Published: January 2024

Per- and polyfluorinated alkyl substances (PFAS) are compounds which exhibit unique chemical and physical properties resulting in bioaccumulation in aquatic and terrestrial food chains. Due to a global concern on the adverse health effects, European Food Safety Authority (EFSA) set tolerable weekly intake and thereafter, to ensure an efficient protection of public health, the European Commission set maximum levels for four priority components, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonic acid (PFOS), in certain foodstuffs. This study demonstrates an analytical method based on high performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) for the quantitative determination of four priority PFAS. The optimized and validated LC-Orbitrap-MS method fulfils the requirements specified in the “Guidance Document on Analytical Parameters for the Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Food and Feed” and allows a reliable analysis of PFAS in selected food products, fulfilling the requirements of Commission Regulation 915/2023, Commission Regulation (EU) 2022/1428, and Commission Recommendation (EU) 2022/1431. The method was successfully used for the compliance testing of four priority PFAS according to the newly established legislation in food samples (n=58) collected in Latvia, providing the occurrence data from the Baltic states.
Systematic review of the feasibility to spare the rectoprostatic fascia in male patients undergoing total mesorectal excision for rectal cancer
Authors: Nikolouzakis Taxiarchis , Gouvas Nikolaos , Athanasakis Elias , Mariolis-Sapsakos Theodoros , Chrysos Emmanouel , Tsiaoussis John
Published: January 2024

Background
The main purpose of this study was to identify feasibility to spare rectoprostatic fascia (RPF) in adult male cadavers and in adult male patients undergoing total mesorectal excision (TME) for rectal cancer. A secondary objective was to evaluate urogenital function following rectal cancer surgery and oncologic outcome.
Methods
Adhering to PRISMA guidelines, we performed a systematic review with a priori design to identify relevant studies using MESH terms and keywords. Research was conducted through 1st of March to 31st of July 2023 in MEDLINE, SCOPUS, Web of Science, Google Scholar and reference lists. Disagreements between individual judgments were resolved with referral to a third researcher.
Results
In total 1211 studies were identified out of which 17 were relevant to the main research question. Overall, 496 living individuals and 25 cadavers were included in whom RPF was identified and spared.
Conclusions
Despite the fact that current practice on rectal cancer surgery dictates TME to extend anterior to the RPF, based on our findings, RPF-spare TME is not only feasible but also important for preserving fair male urogenital function especially for young patients whose erectile function is a priority.
Trial registration number and date of registration:
CRD42020171188, February 2023
Prevalence of Poor Glycemic Control and Associated Factors among Adult Type 2 Diabetes Mellitus Patient at ALERT Hospital, Addis Ababa, Ethiopia, 2022
Authors: Mohammed Fuad Ahmed , Ali Aziza Abdella , Taye Tehetena Assefa
Published: January 2024

Background
Over the last fifty years, type 2 diabetes have become a significant contributor to the global disease burden, and this trend is expected to continue. The Diabetes Prevention Program and the Finnish Diabetes Prevention Study showed the value of primary diabetes prevention, and many studies emphasized the significance of strict management of plasma glucose levels in reducing complications in both type 1 and type 2 diabetes. The aim of this observational study was to assess the prevalence and the associated factors for glycemic control among adult type 2 DM patients at ALERT hospital, Addis Ababa, Ethiopia, 2022.
Method
An institutional based cross-sectional study was employed The study population was adult type 2 DM patients with or without other comorbidities who were on follow at follow up clinic at ALERT hospital. Using a single population proportion formula the final sample size for this study was 371. A systematic random sampling technique was used to select a sample size of 174 pregnant women. The data was collected by trained data collectors being under supervision by the principal investigator. Then, it was cleaned, entered and analyzed using SPSS version 26.0 statistical software and MS excel.
Result
From the 371 participants, 60.9% were male participants; 55.3% between 35 and 64 years of age and 49.1% of them were married. Overall prevalence of poor glycemic control was 89.5%. associated hypertension (p-value = 0.049, AOR = 5.850) was significantly associated with poor glycemic control. having history of hospital admission (p-value = 0.028, AOR = 0.212), recent Fast Blood Sugar of 70-130mg/dl (p-value = 0.003, AOR = 0.025) and access for Self Monitoring of Blood Glucose p-value = 0.021, AOR = 0.046) were negatively associated with poor glycemic control.
Conclusion and Recommendations:
The proportion of poor glycemic control among the type 2 diabetic patients was very high in this study. Educating and preparing methods on managing glycemic control and associated factors for diabetic patients.
Effects of high-molecular-weight glutenin subunit on hard-steamed bread quality
Authors: Zhao Jing , Wang Tianyi , Kai Mengxiang , Zhao Jiajia , Qiao Ling , Wu Bangbang , Hao Yuqiong , Ge Chuan , Wang Juanling , Feng Zhiwei , zheng Jun
Published: January 2024

Steamed bread is used as a daily food in many countries worldwide, but the relationship between high-molecular-weight glutenin (HMW-GS) and steamed bread quality is unclear. Two DH populations of common wheat were used to analyze the effects of twelve HMW-GS subunit combinations on the quality traits of steamed bread, including volume traits, physical properties, and sensory evaluation. The mechanism of trait variation was analyzed by combining the microstructure and dough rheological properties. The results showed that in terms of locus effect, the volume and physical properties of steamed bread were Glu-D1> Glu-B1> Glu-A1, and the effect of sensory score on steamed bun was Glu-B1>Glu-D1>Glu-A1. In terms of individual subunit effects, the volume, chewiness, hardness and so on physical properties indexes and sensory scores of subunit 1 steamed bread at Glu-A1locus were higher than those of subunit N, but the number of cells in subunit N steamed bread was more than subunit 1, as well as the cell diameter and wall thickness were smaller than those of subunit 1 steamed bread. The quality of 7+8 and 7+9 subunits steamed bread at the Glu-B1locus was generally better, and the chewiness, number of cells and so on physical properties indexes and sensory scores were significantly higher than those of 6+8 subunit steamed bread, as well as their physical properties indexes were less affected by moisture. The quality of subunits 2+10 and 5+12 steamed bread at the Glu-D1locus was generally better. Moreover, the specific volume, glueyness, number of cells and so on physical properties were significantly better than those of other subunit steamed bread, as well as the physical properties of subunits 2+10, 5+12 and 2+12 were also less affected by moisture. The effect of subunit combination is mainly affected by subunit, and the combination of superior subunits tends to make steamed bread have better quality traits. The subunit combinations (1,7+8,5+12), (N,7+9,2+10) and (1,7+9,5+12) had better physical properties indexes and sensory scores, and the micro-pore structure was dense, uniform and delicate, and the wall thickness was smaller. However, the combinations (N,7+8,2+12), (N,6+8,2+12) and (N,7+9,5+10) were generally lower in physical properties and sensory scores, and the stomatal structure was looser. The results of different subunits of dough rheological properties showed that the protein content, wet gluten content and stability time were the main factors affecting steamed bread's volume and physical properties. Among the rheological properties of dough, the protein content, wet gluten content and stability time of subunits 7+8, 7+9, 2+10 and 5+12 were higher. Therefore, the volume, physical properties and sensory scores of steamed bread containing these subunits were good.
Controllable Preparation of Hydrangea Shaped CoAl-LDHs@CoF2 Composite for Supercapacitor Electrode with Superior Performance
Authors: Bai Xue , Sun Fengyi , Ma LiYan , Shen Jyunhong , Jiang Zhuwu , Xu Dongdong , Pan Chuntao , Di Hongcheng , Zhang Hongyu
Published: January 2024

Exploring the method for rational design hierarchical structures such as hollow, sphere and core-shell structure is a crucial challenge for enhancing electrochemical performance of supercapacitor electrodes. In this study, we demonstrate a facile method for controllable preparation of hydrangea shaped CoAl-LDHs@CoF2 composite and used as positive electrode for supercapacitor. A series of contrast tests are performed to select optimal experiment condition. CoAl-LDHs obtained at metal ratio of 2:1, reacting 8 h with addition of NH4F, displays optimal performance associated with the hierarchical structure, where NH4F plays a vital role in regulating this uniform generation process. The fabricated working electrode shows high specific capacitance of 827.8 Fg− 1, with excellent capacitance retention of 62.8% after current density increases ten times. At last, an asymmetric supercapacitor using C2A1-8h sample as positive electrode and activated carbon as negative electrode, is assembled and delivers an outstanding energy density of 53.7 Wh kg− 1 at power density of 239.9 kW kg− 1, and energy density reaches 27.8 Wh kg− 1 at maximum power density of 12000 W kg− 1, indicating C2A1-8h is a potential candidate for energy storage and conversion systems.
A comparison of anterior reconstruction of spinal defect using nano-hydroxyapatite/polyamide 66 cage and autologous iliac bone for thoracolumbar tuberculosis: a stepwise propensity score matching analysis
Authors: Li Qiujiang , Xiu Peng , Yang Xi , Wang Lei , Liu Limin , Song Yueming
Published: January 2024

Purpose
Previous studies have confirmed the advantages and disadvantages of autogenous iliac bone and nano-hydroxyapatite/polyamide 66 (n-HA/PA66) cage. However, there is no conclusive comparison between the efficacy of the two implant materials in spinal tuberculosis bone graft fusion. The aim of this study was to analyze the mid- to long-term clinical and radiologic outcomes between n-HA/PA66 cage and autogenous iliac bone for anterior reconstruction application of spinal defect for thoracolumbar tuberculosis.
Methods
We retrospectively reviewed all patients who underwent anterior debridement and strut graft with n-HA/PA66 cage or iliac bone combined with anterior instrumentations between June 2009 and June 2014. One-to-one nearest-neighbor propensity score matching (PSM) was used to match patients who underwent n-HA/PA66 cage to those who underwent iliac bone. Clinical outcomes were assessed using the Japanese Orthopaedic Association (JOA) and visual analogue score (VAS). Radiographic evaluations included cage subsidence and segmental angle.
Results
At the end of the PSM analysis, 16 patients from n-HA/PA66 cage group were matched to 16 patients in Iliac bone group. The C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values in the n‑HA/PA66 group decreased significantly from 33.19 ± 10.89 and 46.63 ± 15.65 preoperatively, to 6.56 ± 2.48 and 9.31 ± 3.34 at the final follow‑up, respectively (P < 0.001). There were no significant differences in the CRP and ESR values between the two groups at the final follow‑up. The VAS and JOA scores in the iliac bone and n‑HA/PA66 group were significantly improved at the 3-month follow-up postoperatively (both P < 0.001). Then, improvements of VAS and JOA scores continue long at final follow-up. However, there were no significant differences in the VAS and JOA scores at any time point between the two groups (P > 0.05). Although the SA significantly increased after surgery in both groups, there was no significant difference at any time point after surgery (P > 0.05). There were no significant differences in the cage subsidence and fusion time between the two groups.
Conclusion
Overall, our data suggest that the n-HA/PA66 cage outcomes are comparable to those in the autogenous iliac bone, with a similar high fusion rate as autogenous iliac bone.
Enhancing Vernier Effect through Integrated Add-Drop Microresonator for High Sensitivity All-Optical Sensing
Authors: Azrisham Nurul Fathinah , Aman Mohammad Amirul Hairol , Noorden Ahmad Fakhrurrazi Ahmad , Bahadoran Mahdi
Published: January 2024

The Vernier effect has recently sparked a lot of interest study in high sensitivity sensing due to its ability to suppress interstitial peaks and broaden the Free Spectral Range (FSR). An analytical simulation system was constructed to incorporate an add-drop Micro Ring Resonator (MRR) waveguide with partial reflecting air holes into the bus waveguide to acquire the interferometric resonance and generate the Vernier effect. The system was developed based on the scattering matrix method and the Optical Transfer Function (OTF). A comparison analysis has been conducted between Conventional Add-Drop (CAD) MRR and Interferometric Add-Drop (IAD) MRR configurations to measure the improved sensitivity. The spectrum was analyzed based on the FSR and the wavelength shift by the change of the refractive index. Both CAD and IAD-MRR have been optimized by varying the radii of the ring and the distance between the air holes in the bus waveguide. The optimized IAD configuration demonstrates a 166.11% enhancement in FSR value and yields higher sensitivity by 17.07% via the implementation of the reflecting holes in the bus waveguide. The IAD-MRR configuration also generated a higher Q factor value of more than four times than the CAD-MRR. These findings emphasize the potential of interferometric resonance in enhancing the Vernier effect thus achieving better performance of all-optical sensing applications.
Knockout of the bread wheat CER9/SUD1 gene using CRISPR/Cas technology
Authors: Musin Khalit , Mikhaylova Elena , Galimova Aizilya , Baimukhametova Elvina , Zaikina Evgenia , Kuluev Azat , Ibragimova Zarina , Rakhmatullina Irina , Berezhneva Zoya , Kuluev Bulat
Published: January 2024

Global warming has underscored the imperative of drought tolerance as a paramount trait in bread wheat. Augmenting the cuticular wax layer on leaves and stems stands as one viable approach to enhancing plant drought tolerance. A pivotal discovery surfaced by identifying a mutation within the CER9 gene of Arabidopsis thaliana, amplifying the cuticular wax and consequently mitigating water loss, thereby fortifying drought resilience. Notably, analogous genes, termed SUD1, have been annotated in bread wheat, albeit lacking in-depth scrutiny regarding their phenotypic manifestations under the drought. Hence, our study aimed to employ CRISPR/Cas technology to knockout the CER9/SUD1 gene in bread wheat. For this, five guide RNAs were meticulously chosen and merged into a singular vector. Delivery of the CRISPR/Cas components were arranged through Agrobacterium tumefaciens, utilized for transforming immature embryos of two agricultural spring bread wheat varieties: Taya and Sigma. Among the 13 transgenic plants procured, four manifested positivity for the reporter gene GFP and Cas9 gene. Notably, substantial deletions ranging from 284 bp to 398 bp within the CER9/SUD1 gene were discerned in these plants. Additionally, two of the edited plants exhibited an absence of CER9/SUD1 transcripts, while the other two displayed a noteworthy 5.4-fold reduction in CER9/SUD1 gene expression compared to the wild type. Intriguingly, the genome-edited plants of the T1 generation showcased enhanced growth compared to the wild type under both standard and drought conditions.
Molecular Characterization of HPV Integrations in High-risk HPV- positive Women and Constructing an Integration Gene-Based Prognostic Risk Model for Cervical Cancer
Authors: Lyu Qiongying , Chen Yurou , Xiong Jiaqiang , Zhang Juan , He Xiaoyan , Wang Hairong , Wang Lihan , Zhang Wei
Published: January 2024

Background
Cervical cancer (CC) ranks fourth in global cancer incidence and represents the second leading cause of cancer deaths. HPV integration into the human genome is a key molecular event in the progression of cancer carcinogenesis.
Methods
This study utilized the high-risk HPV-positive women samples to investigate the HPV integration through the high-throughput Viral Integration Detection (HIVID). Subsequently, the expression of recurrent integration genes at both the mRNA and protein level was determined in GEIPA, and the Human Protein Atlas (HPA). Furthermore, the prognostic risk model of HPV integration genes was constructed using the univariate Cox, least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox analysis from the Cancer Genome Atlas (TCGA) datasets. Then, the prognostic risk model was evaluated with Kaplan-Meier (KM) survival curves and receiver operating characteristic (ROC) curves. The CC patients in TCGA were stratified into high and low risk groups and the differences in PI3K-AKT pathway gene enrichment and immunotherapeutic response differences were analyzed between the two subgroups. Finally, the deferentially expressed immune-related genes (immune DEGs) between the high-risk and low-risk groups were subjected to functional enrichment analysis.
Results
The overall HPV integration rate in high-risk HPV-positive women was 8.75%. We identified 467 integration sites in 82 out of 937 samples. We detected 28 recurrent genes for virus integration in 318 integration genes (reads > = 6), the most frequent were KLF5 (n = 5), LINC00392 (n = 5), BCL11B (n = 3) and TP63 (n = 3).
Impact of climatic-meteorological conditions on the Polish wooden cultural heritage: the example of wooden churches in Krakow
Authors: hu haisheng
Published: January 2024

Poland has a large number of wooden churches, which are significantly threatened by climate change. In this study, we collect geographic, land-use type, water system, climatic and meteorological data of the study area to qualitatively and quantitatively explore the impact of climatic-meteorological conditions on the Polish wooden cultural heritage, using as an example six wooden churches in Wooden Churches of Southern Małopolska (a World Heritage Site) in Kraków. We found that (i) the region rarely experiences extreme precipitation, is located at the headwaters of Polish rivers, and is on higher ground, which makes it less prone to large flood flows, and therefore the impacts of larger hydraulic shocks are rare; (ii) the core and buffer zones where most of the wooden churches are located are densely forested, with a high risk of fires; and (iii) in terms of the current climatic conditions, the year-round relative humidity in the wooden civil churches in Poland exceeds the protection of the wooden heritage or facilities, and the temperature meets the protection criteria only in summer. At the same time, we propose specific recommendations for the conservation and restoration of Polish wooden churches in terms of damp proofing, insulation and drainage, and this study is expected to provide potential data and theoretical support for future related work.
Spatial Variation in Agricultural BMPs and Relationships with Nutrient Yields Across New York State Waterways
Authors: Schewe Rebecca L. , Iavorivska Lidiia , Kelleher Christa
Published: January 2024

Agricultural nutrients nitrogen and phosphorus can subsequently be transported to waterways and are often managed through adoption of best management practices (BMPs). However, we have a poor understanding of how the use of BMPs varies spatially and how BMP adoption might be related to nutrient loads in surface waters. To address this, we performed a survey of agricultural landowners across New York State and compared this with estimates of annual incremental nitrogen and phosphorus loads of agricultural origin from the Spatially Referenced Regressions On Watershed attributes (SPARROW) model. Using these sociobehavioral data and SPARROW predictions, we perform colocation analysis to identify areas where watersheds with high nutrient yield from agriculture are collocated with non-use of agricultural BMPs. This colocation analysis offers a novel methodology for identifying areas where monitoring of waterways and promotion of best management practices could be targeted to achieve the greatest benefits.
A Hybrid Attention Based Deep Learning System for Suicidal Ideation Detection in Social Media
Authors: K SenilSeby , M Elamparithi , V Anuratha
Published: January 2024

Suicide is a critical issue in modern society. Many of the people who have the tendency to suicide share their thoughts and opinions through social media platforms. Suicidal ideation detection via online social network analysis has emerged as an essential research topic with significant difficulties in the fields of natural language processing and psychology in recent years. This paper proposes a hybrid attention-based convolution neural network and long short-term memory (HACNN-LSTM) for suicidal ideation detection of social media data. The proposed system consists of three phases, namely, data preprocessing, word embedding, and classification. To begin, the data preprocessing is carried out on the collected Reddit dataset. After that, the word embedding is performed on the preprocessed dataset by Term Frequency - Inverse Document Frequency (TF-IDF). Finally, the classification is done by using the HACNN-LSTM model, in which the hyperparameter is optimized by particle swarm optimization (PSO) algorithm. The findings proved that the proposed hybrid system achieves superior results than the existing techniques with 96.84% accuracy.
Revolutionizing Soil Remediation: Exploring the Frontiers of Bioremediation Through the Performance Evaluation of Vernonia Galamensis and Vernonia Amydalina Spices in Hydrocarbon-contaminated Soil.
Authors: JOHNSON NNADIKWE
Published: January 2024

The detrimental consequences of soil pollution caused by crude oil or petroleum products are immense, leading to land degradation, property damage, and rendering agricultural practices ineffective. Extensive research has been conducted in the field of soil remediation, but further studies are still required to explore additional details of the remedial process. As a result, this study focuses on evaluating the effectiveness of Vernonia Galamensis and Vernonia Amygdalina, commonly known as bitter leaf, in remediating hydrocarbon-contaminated soil. In the analysis of micro-organisms, it was found that the bitter leaf extracts contained three types of bacteria: Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. The leaf extracts were prepared using different methods, including sun drying, room drying, and using them in their wet form, which were then blended into the contaminated soil. The study also took into consideration three different types of soil: sandy-loamy soil, clay soil, and swamp soil. These advanced techniques and considerations are relevant to the topic of revolutionizing soil remediation, as they explore the potential of bitter leaf extracts and different soil types in effectively mitigating the effects of hydrocarbon contamination.The findings revealed that the wet blended extracts of Vernonia performed exceptionally well in the remediation process, surpassing a 50% reduction in the initial contamination levels. The study involved utilizing a quantity of bitter leaf ranging from 10g to 40g, which was added to the contaminated soils and monitored for a duration of 40 days. Remarkably, this approach led to a significant decrease in the concentration of contaminants within the soil, indicating the effectiveness of the bitter leaf extracts in the remediation process. Towards the conclusion of the study, predictive models were constructed to forecast the impact of hydrocarbon content, as well as the levels of lead, zinc, and chromium in the soil. These variables served as the dependent variables in the models, while the mass of bitter leaf, the duration of treatment, and the pH of the soil were considered as independent variables. Significantly, the models achieved a level of significance of less than 0.05, indicating their statistical validity. Furthermore, the r2 value, which represents the goodness of fit, demonstrated an appreciable level of accuracy in predicting the remediation effects. These results highlight the potential of the developed models in assessing and predicting the remedial outcomes of hydrocarbon contamination using bitter leaf extract.
Ist das Versenden von «Dick Pics» strafbar?
Authors: Thommen Marc , Stark Marvin
Published: January 2024

Mit der Verbreitung von Mobiltelefonen hat auch das Versenden von «Dick Pics» zugenommen. Der vorliegende Beitrag untersucht, wie das Versenden unerwünschter Fotos männlicher Genitalien strafrechtlich zu werten ist. In Frage kommen Exhibitionismus (Art. 194 StGB), Pornografie (Art. 197 StGB) und sexuelle Belästigung (Art. 198 StGB). Dabei wird sich zeigen, dass keiner dieser Tatbestände wirklich passt. Auch nach der Revision des Sexualstrafrechts ist das Problem nicht abschliessend gelöst.

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L'envoi de «Dick Pics» a sensiblement augmentéavec la popularisation des téléphones portables. Notre article examine comment l'envoi de photos non désirées d'organes génitaux masculins doitêtre considérédu point de vue du droit pénal. L'exhibitionnisme (art. 194 CP), la pornographie (art. 197 CP) et le harcèlement sexuel (art. 198 CP) entrent en ligne de compte. Il sera toutefois constatéqu'aucune de ces infractions n'est vraiment adaptée. Même après la révision du droit pénal en matiè re sexuelle, le problème n'est pas définitivement résolu.