bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence Versus Practice: Operative Treatment Preferences in Hallux Valgus
Authors: Noback Peter C. , Trofa David P. , Vosseller J. Turner
Published: December 2018

Background:

There is substantial variability in the operative treatment of hallux valgus despite the existence of high quality evidence to guide treatment decisions. The purpose of this study was to determine the current trends in the treatment of mild, moderate, and severe hallux valgus and if greater degrees of consensus correlate with the presence of higher-level evidence.

Methods:

Members of the American Orthopaedic Foot & Ankle Society completed a 14-item survey. A total of 131 (14%) of 922 members completed the survey. Three cases representing 3 stages of HV were presented, and respondents selected their preferred treatment. Preferred forms of proximal and distal metatarsal osteotomies, as well as mode of fixation for each, were inquired.

Results:

In the treatment of mild hallux valgus without second metatarsalgia, 80% of those surveyed chose a distal metatarsal osteotomy, while, if second metatarsalgia was present, 56% chose a distal metatarsal osteotomy with a second metatarsal-shortening osteotomy. In the treatment of moderate hallux valgus, there was generally less consensus, while, in the treatment of severe hallux valgus, a majority of those surveyed chose a Lapidus procedure, with the addition of a second metatarsal-shortening osteotomy in the presence of second metatarsalgia. The most popular distal and proximal metatarsal osteotomies, respectively, were chevron osteotomy (80%) and opening wedge osteotomy (33%). The presence of Level I evidence did not significantly correlate with higher degrees of consensus.

Conclusion:

Despite the existence of high-quality evidence supporting the use of certain procedures in the treatment of HV, there exists an apparent lack of consensus among surgeons about the choice of surgical procedures. Moreover, higher-level evidence was not correlated with greater consensus in hallux valgus.

Level of Evidence:

Level II.
Development of inverse replica fixture for nano-finishing of knee joint using R-MRAFF process
Authors: Nagdeve Leeladhar , Jain V. K. , Ramkumar J.
Published: December 2018

Rotational-Magnetorheological Abrasive Flow Finishing (R-MRAFF) process is a technique of nano-finishing in general and free-form/sculptured surfaces in particular. Knee joint is one such example of free-form surface which is used by orthopedic surgeons. Knee joints are usually made of cobalt chromium alloy which is bio-compatible material, and it is difficult to finish. The present work deals with the development of an inverse replica for a knee joint. This inverse replica is used as a fixture so that the fluid can flow with constant velocity within the confined gap between the workpiece and inner surface of the fixture in order to achieve uniform nano-level finish. Using this technique, variation in the surface roughness ( Ra) over the knee joint surface can be minimized and productivity can be enhanced. The finishing efficiency of the R-MRAFF process depends on the input parameters such as extrusion pressure, number of finishing cycles, rotational speed of the magnet, etc. These parameters should be controlled and optimized for precision finishing which is the main objective of the present research work. The minimum average Ra of 52 nm is achieved from the initial average Ra of 194 nm on the knee joint surface. The percentage change in Ra (73.20%) was achieved using the proposed method.
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer
Authors: Dobrovolsky Dennis , Wang Eric S. , Morrow Sara , Leahy Catharine , Faust Tyler , Nowak Radosław P. , Donovan Katherine A. , Yang Guang , Li Zhengnian , Fischer Eric S. , Treon Steven P. , Weinstock David M. , Gray Nathanael S.
Published: December 2018

The covalent Bruton tyrosine kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies. However, it is not selective for BTK, and multiple mechanisms of resistance, including the C481S-BTK mutation, can compromise its efficacy. We hypothesized that small-molecule–induced BTK degradation may overcome some of the limitations of traditional enzymatic inhibitors. Here, we demonstrate that BTK degradation results in potent suppression of signaling and proliferation in cancer cells and that BTK degraders efficiently degrade C481S-BTK. Moreover, we discovered DD-03-171, an optimized lead compound that exhibits enhanced antiproliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1, and IKFZ3 as well as efficacy against patient-derived xenografts in vivo. Thus, “triple degradation” may be an effective therapeutic approach for treating MCL and overcoming ibrutinib resistance, thereby addressing a major unmet need in the treatment of MCL and other B-cell lymphomas.
Pulmonary hypertension in chronic lung disease and hypoxia
Authors: Nathan Steven D. , Barbera Joan A. , Gaine Sean P. , Harari Sergio , Martinez Fernando J. , Olschewski Horst , Olsson Karen M. , Peacock Andrew J. , Pepke-Zaba Joanna , Provencher Steeve , Weissmann Norbert , Seeger Werner
Published: December 2018

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Haemodynamic evaluation of PH severity should be contextualised within the extent of the underlying lung disease, which is best gauged through a combination of physiological and imaging assessment. Who, when, if and how to screen for PH will be addressed in this article, as will the current state of knowledge with regard to the role of treatment with pulmonary vasoactive agents. Although such therapy cannot be endorsed given the current state of findings, future studies in this area are strongly encouraged.
The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model
Authors: Meir Michal , Bifani Pablo , Barkan Daniel
Published: December 2018

Treating M. abscessus infection is challenging due to the potent β-lactamase BlaMab (Beta-lactamase of M. abscessus). Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit BlaMab. We tested whether avibactem can render piperacillin effective against M. Abscessus. In-vitro, avibactam enhanced the activity of piperacillin by 16–32 fold, with no significant effect on meropenem. In an in-vivo Galleria mellonella model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect.
Effective Q-compensated reverse time migration using new decoupled fractional Laplacian viscoacoustic wave equation
Authors: Li Qingqing , Fu Li-Yun , Zhou Hui , Wei Wei , Hou Wanting
Published: December 2018

Seismic waves are attenuated and distorted during propagation because of the conversion of acoustic energy to heat energy. We focus on intrinsic attenuation, which is caused by [Formula: see text], which is the portion of energy lost during each cycle or wavelength. Amplitude attenuation can decrease the energy of the wavefields, and dispersion effects distort the phase of seismic waves. Attenuation and dispersion effects can reduce the resolution of image, and they can especially distort the real position of interfaces. On the basis of the viscoacoustic wave equation consisting of a single standard linear solid, we have derived a new viscoacoustic wave equation with decoupled amplitude attenuation and phase dispersion. Subsequently, we adopt a theoretical framework of viscoacoustic reverse time migration that can compensate the amplitude loss and the phase dispersion. Compared with the other variable fractional Laplacian viscoacoustic wave equations with decoupled amplitude attenuation and phase dispersion terms, the order of the Laplacian operator in our equation is a constant. The amplitude attenuation term is solved by pseudospectral method, and only one fast Fourier transform is required in each time step. The phase dispersion term can be computed using a finite-difference method. Numerical examples prove that our equation can accurately simulate the attenuation effects very well. Simulation of the new viscoacoustic equation indicates high efficiency because only one constant fractional Laplacian operator exists in this new viscoacoustic wave equation, which can reduce the number of inverse Fourier transforms to improve the computation efficiency of forward modeling and [Formula: see text]-compensated reverse time migration ([Formula: see text]-RTM). We tested the [Formula: see text]-RTM by using Marmousi and BP gas models and compared the [Formula: see text]-RTM images with those without compensation and attenuation (the reference image). [Formula: see text]-RTM results match well with the reference images. We also compared the field data migration images with and without compensation. Results demonstrate the accuracy and efficiency of the presented new viscoacoustic wave equation.
Uniaxial Cyclic Tests on Reinforced Concrete Members with Lap Splices
Authors: Tarquini Danilo , Almeida João P. , Beyer Katrin
Published: December 2018

This data paper presents the quasi-static uniaxial cyclic tests of 24 reinforced concrete members, of which 22 feature lap splices and 2 are reference units with continuous reinforcement. The objective of the experimental program is to investigate the influence of lap splice length ( ls), confining reinforcement, and loading history on the behavior of lap splices. Particular attention is placed on the measurement of local deformation quantities, such as lap splice strains and rebar-concrete slip. Details of the geometry and reinforcement layout of the specimens as well as the employed test setup, instrumentation, and loading protocols are provided. The global behavior of the test units, including the observed crack pattern and failure modes, are discussed. The organization of the experimental data, which are made available for public use under DOI: 10.5281/zenodo.1205887, is outlined in detail.
Cytokine, Chemokine, and Cytokine Receptor Changes Are Associated With Metabolic Improvements After Bariatric Surgery
Authors: Wolf Risa M , Jaffe Andrew E , Steele Kimberley E , Schweitzer Michael A , Magnuson Thomas H , Wolfe Andrew , Wong G William
Published: December 2018

Context

Altered cytokine levels and chronic low-grade inflammation contribute to metabolic dysfunction in obesity. The extent of cytokine changes and their impact on metabolic improvements after bariatric surgery have not been fully explored.

Objective

To compare 76 circulating cytokines, chemokines, and secreted cytokine receptors in subjects with obesity and lean subjects and determine how these cytokines are altered by bariatric surgery.

Design, Setting, and Participants

A total of 37 patients with obesity and 37 lean patients in a cross-sectional study at an academic medical center. We also investigated cytokine changes in 25 patients with obesity after bariatric surgery.

Intervention

Bariatric surgery (Roux-en-Y gastric bypass and vertical sleeve gastrectomy).

Main Outcome Measures

Quantification of 76 circulating cytokines, chemokines, and secreted cytokine receptors.

Results

A total of 13 cytokines were significantly higher, and 4 lower, in patients with obesity relative to lean controls. Soluble vascular endothelial growth factor receptor 2 (sVEGFR2), soluble TNF receptor (sTNFR) 1, and sTNFR2 were positively correlated, and soluble receptor for advanced glycation end-products was inversely correlated, with weight and body mass index. sTNFR2 was positively correlated with fasting glucose, homeostatic model assessment of insulin resistance, and hemoglobin A1c. After bariatric surgery, adiponectin increased, and leptin decreased. Elevated sVEGFR2 levels in patients with obesity were decreased (P = 0.01), whereas reduced chemokine (C-X-C motif) ligand (CXCL) 12 levels in patients with obesity increased (P = 0.03) after surgery. Patients with higher soluble interleukin receptor (sIL) 1R2 and sIL-6R levels before surgery had greater weight loss after surgery (P < 0.05).

Conclusions

We demonstrate that chemokine (C-C motif) ligand (CCL) 14, sVEGFR2, and platelet-derived growth factor BB are elevated in obesity, and CXCL12, CCL11, and CCL27 are lower in obesity. We found clinically concordant directionality between lean and patients with obesity and before vs after surgery for six cytokines, suggesting that bariatric surgery shifted the cytokine profiles of patients with obesity toward that of lean controls.
A survey of quality of life indicators in the Romanian Roma population following the ‘Decade of Roma Inclusion’
Authors: Powell Doherty Rebecca , Telionis Pyrros A. , Müller-Demary Daniel , Hosszu Alexandra , Duminica Ana , Bertke Andrea , Lewis Bryan , Eubank Stephen
Published: December 2018

Background: This study explores how the Roma in Romania, the EU’s most concentrated population, are faring in terms of a number of quality of life indicators, including poverty levels, healthcare, education, water, sanitation, and hygiene. It further explores the role of synthetic populations and modelling in identifying at-risk populations and delivering targeted aid.

Methods: 135 surveys were conducted across five geographically diverse Romanian communities. Household participants were selected through a comprehensive random walk method. Analyses were conducted on all data using Pandas for Python. Combining land scan data, time-use survey analyses, interview data, and ArcGIS, the resulting synthetic population was analysed via classification and regression tree (CART) analysis to identify hot-spots of need, both ethnically and geographically.

Results: These data indicate that the Roma in Romania face significant disparities in education, with Roma students less likely to progress beyond 8 th grade. In addition, the Roma population remains significantly disadvantaged with regard to safe and secure housing, poverty, and healthcare status, particularly in connection to diarrheal disease. In contrast, however, both Roma and non-Roma in rural areas face difficulties regarding full-time employment, sanitation, and water, sanitation, and hygiene infrastructure. In addition, the use of a synthetic population can generate information about ‘hot spots’ of need, based on geography, ethnicity, and type of aid required.

Conclusions: These data demonstrate the challenges that remain to the Roma population in Romania, and also point to the myriad of ways in which all rural Romanians, regardless of ethnicity, are encountering hardship. This study highlights an approach that combines traditional survey data with more wide-reaching geographically based data and CART analysis to determine ‘hot spot’ areas of need in a given population. With the appropriate inputs, this tool can be extrapolated to any population in any country.
PROFILE OF BRONCHIAL INFLAMMATION AND CLINICAL FEATURES OF MILD BRONCHIAL ASTHMA
Authors: Пирогов Алексей , Pirogov Aleksey , Перельман Юлий , Perelman Yuliy , Приходько Анна , Prikhodko Anna , Ульянычев Николай , Ulyanychev Nikolay
Published: December 2018

Heterogeneity of respiratory tract inflammation determines the clinical course and control of mild asthma. The aim of the research was to study the relationship between clinical and functional parameters and the form of bronchial inflammation in patients with mild persistent asthma against the background of standard basic anti-inflammatory therapy. In 198 patients with mild asthma (the mean age was 41.5±0.7 years old) against the background of maintenance therapy with low doses of inhaled glucocorticosteroids (ICS at a dose ≤500 mcg/day by beclomethasone dipropionate), there were determined the level of asthma control according to the questionnaire Asthma Control Test (ACT), lung function, airway reaction to 3-minute isocapnic hyperventilation with cold (-20ºC) air; there was done the collection of induced sputum (IS). The content of cells in cytograms of IS was assessed. The activity of myeloperoxidase (MPO) (in pixels) was measured by cytochemical method in neutrophilic and eosinophilic granulocytes. Group 1 (n=43; 22%) included patients with the eosinophilic pattern of bronchial inflammation, group 2 (n=155; 78%) included patients with mixed pattern of inflammation. In group 2, unlike the patients of group 1, in the inflammatory profile of infiltrate against the background of high neutrophil content (34.6±1.1 and 10.8±0.5%, respectively; p=0.000001), there was found an increased level of eosinophils (17.0±1.1 vs. 21.2±1.8%, respectively; p=0.048), and there was revealed a higher intragranular deposition of MPO (85.8±3.5 vs. 77.0±3.2 pixels, respectively; p=0.057). The mixed type of inflammation with the dominant neutrophil component and the greatest activity of MPO was associated with more pronounced clinical symptoms of the disease and low level of asthma control (16.0±0.7 vs. 18.7±0.4 ACT points, respectively; p=0.004), lung function decrease (FEV1 was 89.4±1.4 vs. 97.9±2.2%, respectively; p=0.005) and degree of FEV1 drop in response to bronchial provocation by cold air (-10.1±1.1 vs. -3.4±1.1%, respectively; p=0.002), due to insufficient anti-inflammatory effect of the used controller therapy. A discriminant equation is proposed, which can serve as an additional criterion for the effectiveness of anti-inflammatory therapy.
EFFICIANCY OF IMMUNOTHERAPY IN PATIENTS WITH PERSISTENT ALLERGIC RHINITIS
Authors: Антонюк Марина , Antonyuk Marina , Сулейманов С , Suleymanov S , Гвозденко Татьяна , Gvozdenko Tatyana , Новгородцева Татьяна , Novgorodtseva Tatyana
Published: December 2018

The dynamics of parameters of cytokine status in patients with allergic rhinitis in view of efficiency of allergen-specific immunotherapy (ASIT) was studied in this work. 62 subjects with moderate persistent rhinitis at the age of 18-40 years old were included in the study. For specific diagnosis and treatment there we used standard allergens. ASIT was performed by the classical scheme. The concentrations of IL-4, IL-5, IL-6, IL-8 in the blood serum were measured by the enzyme immunoassay. A good or excellent effect of treatment with ASIT was achieved in 62.9% of cases, and satisfactory one in 37.1% of cases. The analysis of the dynamics of IL-4, IL-5, IL-6, IL-8 concentrations showed that the efficiency of ASIT in patients with allergic rhinitis depends on the ability of the immune system to activation by low doses of the allergen, quite fast suppression of proinflammatory cytokines induced by them, and active functioning of the system of anti-inflammatory cytokines.
THE ROLE OF LUNGS IN BALANCE OF THE HEMOSTASIS SYSTEM IN THE CHRONIC EXPOSURE TO AIR POLLUTANTS
Authors: Голубкина Е , Golubkina E , Дюкарева О , Dyukareva O , Тризно Н , Trizno N , Удочкина Л , Udochkina L , Тризно М , Trizno M
Published: December 2018

The aim of the study is to determine the nature of the consequences of non-respiratory lung function disorders and their influence on the hemostatic system in chronic inhalation of industrial hydrogen sulfide gas (HS). There were studied the parameters of hemostasis system (the number and function of platelet, total clotting time, level of soluble fibrin-monomer complex and D-dimer, speed of XIIa-dependent euglobulin lysis, the activity of Willebrand factor and factors VIII, protein C and inhibitor of tissue plasminogen activator-1 (TPA-1), the content of antithrombin III and plasminogen) in 146 white laboratory male rats taking into account the artery-venous difference. Blood collection was carried out from the abdominal aorta (pars abdominalis aortae) ("after the lungs") and from the posterior vena cava (vena cava caudalis) ("to the lungs", that excludes the influence of the liver). The rats were divided into 9 groups: four groups were experimental, which were exposed to HS for one month (20 animals), two months (20 animals), three months (19 animals) and four months (19 animals). HS was fed into chambers at a concentration of 70±2.34 mg/m3 by static method (once). Inhalation of rats with gas lasted for 4 hours a day, 5 days a week. The control groups were rats placed in cells with a normal air composition in a similar mode for a period of one, two, three and four months (12 individuals each). The reference parameters of the hemostatic system were determined before the experiment in a group of 20 rats. It was found that the artery-venous difference in the indicators of soluble fibrin-monomer complex (p<0.05), the content of antithrombin III (p<0.05), the activity of protein C (p<0.01) is more pronounced in the groups of the 1st month of exposure to HS. Increased activity of platelets (p<0.05), of Willebrand factor (p<0.05) and TPA-1 (p<0.001), as well as slowing of fibrinolysis (p<0.05) indicates the damage to the endothelium of pulmonary capillaries by the 4th month of HS inhalation and the decrease of ability of the lungs to regulate hemostasiological balance.
MORPHOMETRIC FEATURES OF TERMINAL VILLI IN PRETERM PLACENTA
Authors: Островская Ольга , Ostrovskaya Olga , Кожарская Ольга , Kozharskaya Ol'ga , Супрун Стефания , Suprun Stefaniya , Мусатов Денис , Musatov Denis , Обухова Виктория , Obuhova Viktoriya , Ивахнишина Наталья , Ivakhnishina Natalya , Наговицына Елена , Nagovitsyna E , Власова Марина , Vlasova Marina , Лебедько Ольга , Lebedko Olga
Published: December 2018

In this study, morphometric features of terminal villi in term and preterm placentas were compared. Placentas of 13 patients whose pregnancy ended in premature birth and placentas of 35 women with physiological pregnancy and delivery at term were studied. Morphometric assessment was made with Carl Zeiss Axio Imager microscope using an image analysis software package. The number of capillaries in terminal villi of preterm placentas was found to be decreased, while the vessels-to-syncytiotrophoblast distance was found to be increased. These result in a decreased gas exchange between maternal blood and placental tissue, hypoxia and can cause early termination of pregnancy. Mean values of cross-sectional area, vertical dimension and perimeter of terminal villi in preterm placentas are found to be greater than those in term placentas, which contributed to an increase in gas exchange area and can be regarded as a compensatory reaction at a tissue level.
UNUSUAL COURSE OF THE GOODPASTURE SYNDROME IN THE ELDERLY PATIENT (THE CASE FROM PRACTICE)
Authors: Круглякова Людмила , Kruglyakova Lyudmila
Published: December 2018

Goodpasture syndrome belongs to infrequent diseases and is shown by a hemorrhagic pulmonitis and glomerulonephritis (is more often proliferative), and extremely adverse course (the lethal outcome comes within 6 months – 1.5 years). Children and people of young age have this pathology mainly. We show a casuistic case of a long course (about 3 years) of Goodpasture syndrome in the person of 65 years old.
La arbitrabilidad subjetiva en el contrato de fiducia en Colombia.
Authors: Ortegón Obando Sebastián
Published: December 2018

El objetivo del presente artículo es hacer una reflexión práctica sobre los problemas alrededor de los pactos arbitrales en materia de contratos de fiducia. En particular, sobre los problemas que pueden surgir para los no signatarios del pacto arbitral. La metodología empleada para la elaboración del presente estudio fue el análisis dogmático de casos jurisdiccionales, así como de la doctrina nacional e internacional sobre la materia. En primer lugar, se revisan detenidamente las diferentes aproximaciones teóricas que se han realizado con el fin de caracterizar lo que este artículo cataloga como 2 tendencias en la materia: rígida y flexible. Posteriormente se estudian algunas hipótesis prácticas que pueden surgir dada la estructura del contrato, para demostrar que las figuras que en la actualidad son utilizadas pueden redundar en la violación de los derechos de terceros.
Los contratos normativos y los contratos marco en el derecho privado contemporáneo
Authors: Castro de Cifuentes Marcela
Published: December 2018

La libertad de configuración contractual permite a los particulares diseñar los instrumentos jurídicos que regirán su relación negocial. Las partes bien pueden utilizar los tipos establecidos en el ordenamiento o pueden crear un acuerdo a su medida que refleje la operación específica que se proponen. También pueden establecer una metodología y unas etapas en la formación del contrato, que vayan desde las primeras conversaciones hasta la conclusión y perfeccionamiento del negocio.El “contrato normativo” y el “contrato marco” son instrumentos empleados con frecuencia en la contratación contemporánea. Por su importancia, han sido objeto de estudio en el ámbito del derecho, pero no hay consenso alrededor de su concepto, su naturaleza y sus efectos. El presente documento presenta los elementos fundamentales que nutren los contratos normativos y los contratos marco, analiza sus principales problemáticas y finalmente plantea unas preguntas de reflexión al respecto.
Los acuerdos prematrimoniales en Derecho Internacional Privado español
Authors: Antón Juárez Isabel
Published: December 2018

Los acuerdos prematrimoniales son una figura cada vez más frecuente en el tráfico jurídico internacional. Atrás quedó la concepción de que se trata de un negocio jurídico relegado a ricos y estrellas del cine. En la actualidad debido a la movilidad de las personas, los matrimonios en los que los cónyuges no comparten nacionalidad son bastantes frecuentes. Sin embargo, igual que la frecuencia en su celebración es habitual también que acaben en divorcio. Con este motivo, muchos de ellos deciden regular mediante un acuerdo prematrimonial los efectos de una posible ruptura. El objeto de nuestro estudio es el análisis de estos pactos desde un punto de vista internacional privatista. Como consecuencia de los diferentes elementos extranjeros que pueden presentar estos pactos resulta necesario determinar qué derecho resulta de aplicación para saber si son válidos. Para llegar a tal derecho es necesario tener en cuenta las normas de Derecho internacional privado. En particular, centraremos el estudio en el art. 9.3 del código civil español.
Preliminares
Authors: Socio-Jurídicos Estudios
Published: December 2018

...
Wasserstein Distance and the Distributionally Robust TSP
Authors: Carlsson John Gunnar , Behroozi Mehdi , Mihic Kresimir
Published: December 2018

One of the most common strategies used in large-scale logistics problems is districting, in which one divides a service region into smaller pieces. This is particularly useful when one does not know the true locations of demand, but has only limited information such as a probability distribution or a small set of sample data. In “Wasserstein Distance and the Distributionally Robust TSP,” Carlsson et al. show how to partition a region so as to balance the traveling salesman tours of a set of unknown points, using a distributionally robust method defined by a bound on the Wasserstein distance to a set of landmark points.
Associação entre adesão ao tratamento anti-hipertensivo e integralidade no atendimento de enfermeiros
Authors: Sousa Antônia Sylca de Jesus , Moreira Thereza Maria Magalhães , Machado Ana Larissa Gomes , Silva Ana Zaira da
Published: December 2018

Objetivo: verificar a associação entre nível de adesão dos clientes ao tratamento anti-hipertensivo e a integralidade no atendimento de enfermeiros. Método: pesquisa de abordagem quantitativa, desenvolvida na cidade de Fortaleza-CE, com 602 hipertensos atendidos em um Centro de Saúde de Atenção Secundária. Para identificar a presença ou não da adesão, aplicou-se o Teste de Morisky-Green e a presença da integralidade na assistência foi obtida por um check-list baseado nos pressupostos da Starfield (acessibilidade, acolhimento, vínculo e enfoque familiar). Foi realizado um entrecruzamento das variáveis por meio do teste estatístico Quiquadrado de Pearson (X2). O presente estudo foi aprovado pelo Comitê de Ética em Pesquisa. Resultados: não houve associação entre adesão e integralidade no atendimento de enfermeiros (p=0,758). Conclusão: verifica-se a necessidade de se realizar um cuidado de enfermagem centrado na integralidade da assistência, de forma a buscar cada vez a adesão dos pacientes hipertensos ao tratamento.
Significado das ações educativas na consulta de enfermagem para clientes renais crônicos e familiares
Authors: Menezes Harlon França de , Rosas Ann Mary Machado Tinoco Feitosa , Camacho Alessandra Conceição Leite Funchal , Souza Flávia Silva de , Rodrigues Benedita Maria Rêgo Deusdará , Da Silva Richardson Augusto Rosendo
Published: December 2018

Objetivo: compreender o significado das ações educativas na consulta de enfermagem para clientes renais crônicos em tratamento conservador e seus familiares. Método: estudo orientado pela Fenomenologia Social. Entre novembro de 2015 e abril de 2016, realizaram-se entrevistas com 12 clientes renais crônicos de um ambulatório de nefrologia de um hospital universitário e seus familiares, localizado no estado do Rio de Janeiro, Brasil, após aprovação dos Comitês de Ética em Pesquisa da instituição proponente e coparticipante. As entrevistas foram transcritas e submetidas à análise de acordo com a literatura relacionada. Resultados: emergiram duas categorias: Expectativas ao ir à consulta de enfermagem e Cuidando do outro para enfrentar as adversidades impostas pela doença. Conclusão: o estudo permitiu compreender que, no cotidiano desses indivíduos, eles adquirem habilidade e prática para lidar com suas limitações. As relações que possuem possibilitam subsídios para o reconhecimento dos valores não apenas da clínica como do valor enfocado no cuidado relacional.
Anemia ferropriva e o uso do sulfato ferroso: facilidades e dificuldades na prevenção
Authors: Henrique Nayara Cristina Pereira , Wolkers Paula Carolina Bejo , Furtado Maria Cândida De Carvalho , Toriyama Aurea Tamami Minagawa , Mello Débora Falleiros de
Published: December 2018

Objetivo: Apreender os saberes de mães/cuidadores com relação à anemia ferropriva e o uso preventivo do sulfato ferroso, com ênfase nos elementos que facilitam e dificultam a prevenção da enfermidade. Método: Estudo exploratório qualitativo com análise temática indutiva dos dados, realizado por meio de entrevistas com 12 mães/cuidadores de crianças entre seis meses e 11 meses e 29 dias de idade, em acompanhamento em unidade de saúde da família de um município brasileiro. Resultados: A alimentação saudável foi apontada como elemento facilitador na prevenção da anemia ferropriva. Fragilidades nos conhecimentos sobre a enfermidade e o sulfato ferroso como estratégia preventiva, falhas na prescrição do medicamento e uso cotidiano, e poucas orientações foram os elementos que dificultam a prevenção da doença. Conclusão: Práticas educativas em saúde na prevenção da anemia ferropriva são essenciais, sinalizando informações sobre a enfermidade e o monitoramento da suplementação profilática, fortalecendo o cuidado da saúde da criança.
Lobbying practices in Israel’s advocacy groups
Authors: Mano Rita
Published: December 2018

This paper assesses the degree to which the Libby Lobbying Model (LLM) describes the lobbying practices of advocacy groups in Israel. We conclude that the model is useful in describing advocacy activities in Israel, yet deviations from the model are evident as well. We propose that Israeli organisations could usefully adopt a modified version of the LLM, adapted to their own specific conditions, in order to strengthen the planning and evaluation of their lobbying activity.
La amplificación retórica de la fábula del asno y la raposa en el ms. 6513 de la Biblioteca Nacional de España
Authors: Pérez Custodio Violeta
Published: December 2018

El manuscrito 6513 de la Biblioteca Nacional de España contiene una extensa colección de textos producidos en escuelas jesuitas durante los siglos XVI y XVII.Entre estos materiales se encuentra una amplificación retórica de la fábula esópica del asno que, disfrazado con una piel de león, fue descubierto por una raposa. En el presente artículo se edita y analiza esta breve pieza, a fin de mostrar que el texto se inspira en la fábula del león y la raposa incluida en los progymnasmata publicados por Bartolomé Bravo, S. I.
COELHO, Maria Helena da Cruz, e REBELO, António Manuel Ribeiro, D. Pedro e D. Inês. Diálogos entre o Amor e a Morte. “Sermão das Exéquias de D. Inês de Castro” de D. João de Cardaillac. Edição crítica, tradução e comentário filológico, Coimbra
Authors: De Nazaré Castro Soares Nair
Published: December 2018

Recensão
When results matter: reliable creatinine concentrations in hyperbilirubinemia patients
Authors: Roelofsen-de Beer Roseri J.A.C. , van Zelst Bertrand D. , Vroling Aram B. , de Rijke Yolanda B. , Ramakers Christian
Published: December 2018

Background

Failure to report a creatinine concentration, especially in icteric patients who are eligible for a liver transplant, can result in a life-threatening situation. We assessed the influence of bilirubin interference on several creatinine assays and investigated ways to circumvent icteric interference without interfering with our normal automated sample logistics.

Methods

Using icteric patient sera (total bilirubin >255 μmol/L) we determined creatinine concentrations using an enzymatic and Jaffé assay (Roche Diagnostics) in both normal (i.e. undiluted) and decreased mode (i.e. diluted) as well as an enzyme-coupled amperometric assay on a Radiometer ABL837 FLEX analyzer. Creatinine concentrations from the five methods were compared with an in-house developed LC-MS/MS method. Passing and Bablok (proportional and constant bias) as well as difference plot parameters (bias and 95% limits of agreement [LoA]) were calculated. Interferograph-based regression analysis of the enzymatic and Jaffé results was used to investigate if such an approach could be used to report corrected creatinine concentrations in icteric patient sera.

Results

In icteric patient sera the enzyme-coupled amperometric assay was hardly influenced by icteric interference as shown by a difference plot bias of −1.5% (95% LoA −11.6 to +8.5%). The undiluted Jaffé method had a bias of −1.4% with a very broad 95% LoA (−35.1 to +32.2%) emphasizing the poor specificity of this method. The undiluted enzymatic method had the largest bias (−13.4%, 95% LoA −35.8 to +9.0%). Diluting sera in the enzymatic method did not improve the bias (−10.5%, 95% LoA −25.4 to 4.4%), while diluting the Jaffé method resulted in a bias increase (+11.4%, 95% LoA −14.7 to 37.5%). Using interferograph-based regression analysis we were able to reliably correct enzymatic creatinine concentrations in 97 out of 100 icteric patient sera.

Conclusions

Analytically, quantifying creatinine in icteric sera using the Radiometer ABL837 FLEX analyzer is the method of choice within our laboratory. However, not all laboratories are equipped with this method and even if available, the limited number of highly icteric patient sera makes this method costly. For those laboratories using the Roche enzymatic method, mathematically correcting an icteric creatinine concentration using an interferograph based on an LC-MS/MS reference method is a suitable alternative to report reliable creatinine results in icteric patients.
A Diffusion Cell for the Mass Transfer Investigation in the Solid Porous Media
Authors: Zhokh Alexey , Trypolskyi Andrey , Strizhak Peter
Published: December 2018

A diffusion cell for the mass transfer investigation of the gases through the solid porous media is developed. The diffusion cell may be configured in two different ways. One configuration corresponds to the reflecting boundary condition, whereas another configuration satisfies the absorbing boundary. The mass balance equations for different cell configurations are provided. The mass balance equations are applicable for the calculations of the diffusate quantity decays. The latter are suitable for the mass transfer parameters estimation using the solutions of the transport equations, obtained for the boundary conditions that correspond to the diffusion cell configurations. Accounting for the impact of the apparatus function of the diffusion cell on the experimental data is also revisited. In addition, the practical use of the diffusion cell based on the installation of the cell into the gas chromatograph for the investigation of the methane transport through the porous silica pellet as an example is demonstrated.
Why bother: usefulness and effect of young surgeon committees in surgical societies
Authors: Lutz Brigitta M. , Braun Benedikt J. , Blank Beate , Mutschler Manuel
Published: December 2018

Work-time constraints during surgical residency along with managing a private life usually take up the majority of the time of young surgeons. For many, work with a surgical society seems like something neither generally promising nor personally worthwhile, thus raising the question, why bother? This article sets out to show examples of the effects that surgical societies and young surgeon committees can have on surgery and residency training. Additionally, we highlight the personal side of being active on a committee. Our aim is to raise interest in participating in societal work by showing the rewarding general effects as well as personal benefits. While this article is based primarily on experiences made in Germany, we believe that aspects can be transferred to other medical systems.
Structural Performance of Concrete Beams with Micro-reinforcement Strengthened with GFRP Laminates under Monotonic Loading
Authors: Rex L. K. , Premalatha P. V.
Published: December 2018

The behavior of structural elements under different loading conditions decides the performance of the built structures. Fiber-reinforced concrete and fiber-reinforced polymers (FRPs) have received increasing attention in recent years for many structural applications. Steel fibers, when added into concrete as micro-reinforcement, impart a bridging effect, resulting in enhanced mechanical properties. FRPs are most commonly composed of glass, aramid, or carbon fibers in a polymeric matrix and can be tailor-made to provide a large variety of material properties to suit the prerequisites of the engineer. This article presents an experimental investigation of steel fiber reinforced concrete beams externally strengthened with glass fiber reinforced polymer (GFRP) laminates to study their static flexural behavior and failure modes. The experimental program consisted of six concrete beams strengthened with GFRP laminates, and one concrete beam was left unstrengthened to serve as the control beam. The beams were designed for under-reinforced conditions and cast with different fiber volume fractions (Vf) and GFRP laminate thickness (tf). The beams were tested under monotonic loading until failure. The experimental results showed that the strengthened beams exhibit significantly improved performance compared with the control beams in terms of strength, deformation, ductility, and crack resistance under monotonic loads.
A Kinematic Calibration Method of the Articulated Arm Coordinate Measuring Machine Using Niching Chaos Optimization Algorithm
Authors: Rim Cholmin , Rim Chang-Hyon , Chen Gang , Sin Yongchol , Kim Kukchol
Published: December 2018

Articulated arm coordinate measuring machine (AACMM) is a kind of portable coordinate measuring equipment, which employs a series of rotating joints. In order to improve the measuring accuracy and repeatability of AACMM, it is essential to calibrate the kinematic parameters of AACMM. The calibration process is a kind of nonlinear optimization problem and can be solved by employing various optimization algorithms most including Levenberg–Marquardt algorithm (LMA) and trust region algorithm. Recently, evolutionary computation (EC) has been extensively studied and applied to many engineering problems, since they have some positive features such as easy implementation, broad applicability and robust mechanism of escaping from the local optimum. Chaos optimization algorithm (COA) is one of the evolutionary computation, which utilizes chaotic numerical sequences. In this article, a new kinematic calibration approach for AACMM is proposed by using niching chaos optimization algorithm (NCOA). A hybrid objective function for kinematic calibration is proposed that reflects the various performance tests including single-point articulation performance test, effective diameter performance test and volumetric performance test. Levenberg–Marquardt algorithm and niching chaos optimization algorithm are applied for calibrating the kinematic parameters. Niching chaos optimization algorithm shows competitive calibration performance to Levenberg–Marquardt algorithm. The experimental results demonstrate that the measurement accuracy calibrated using NCOA has been better than that of using LMA in terms of the root-mean-square deviation. The experimental results demonstrate that the measurement accuracy calibrated using NCOA has been better than that of using LMA in terms of the root-mean-square deviation.
Pensiones de Jubilación a la luz del Acto Legislativo 01 de 2005
Authors: Castellanos Ávila Luis Eduardo
Published: December 2018

El proyecto de investigación presenta una aplicación de una metodología analítica que estudia constitucionalmente el tema central, que tiene como objeto el procurar demostrar cómo el referido Acto Legislativo No. 01 del 2005 modificatorio del artículo 48 de la Constitución Política, además de contrariar disposiciones que consagra la misma Carta Política, en materia del derecho de asociación sindical y negociación colectiva por la restricción que se estableció al ejercicio del derecho a la negociación colectiva, artículo 55 de la C.P., derecho este cuyo arraigo en esencia tiene origen en el derecho fundamental de la asociación sindical, consagrado en el artículo 39 de la Constitución Política, desconociendo lo señalado en los Convenios Internacionales del Trabajo, particularmente el Convenio 87 y 98 (OIT), disposiciones calificadas por la doctrina constitucional como parte integral del denominado Bloque de Constitucionalidad, en virtud del inciso 2° del artículo 93 de la Constitución Política, característica reforzada por lo determinado en el inciso 4° del artículo 53 de la Constitución Política. De la misma manera, la enmienda constitucional por la cual se reformó el artículo 48 de la Constitución Política deja ver ostensiblemente cómo se desconoce el derecho a la propiedad privada y a la libertad de empresa al prohibir la negociación colectiva entre particulares, chocando de contera con lo establecido en el artículo 58 de la Constitución Política y lo dispuesto en el artículo 333 constitucional, que garantiza el derecho a la propiedad y el reconocimiento a los derechos adquiridos conforme a la ley, al igual que el derecho a la libertad de empresa bajo una función social determinada.El análisis del trabajo determinó que la exclusión a la restricción de la negociación colectiva que estableció el Acto Legislativo No. 01 de 2005 en materia pensional configura una antinomia constitucional, que lesiona en forma grave el mecanismo de concertación por medio de la negociación colectiva, que tienen los trabajadores para acordar y mejorar las condiciones mínimas del trabajo previstas en la normativa legal.
Caracterización de los signos clínicos del Síndrome Combinado de Kelly en el hogar geriátrico de la ciudad de Bucaramanga
Authors: Blanco Villamizar Ligia Lizeth , Capacho Vera Wilmer Francisco , Picón Peña Jairo Fernando
Published: December 2018

Objetivo: establecer la frecuencia de los signos del Síndrome Combinado de Kelly (SCK) de un hogar geriátrico de la ciudad de Bucaramanga.Materiales y métodos: se realizó un estudio observacional descriptivo de corte transversal. La muestra la constituyeron 79 personas a quienes se les aplicó un instrumento y posteriormente fueron evaluados mediante un examen clínico intraoral para determinar la presencia de los signos según los criterios del instrumento. El análisis estadístico se realizó en el programa Stata/MP 14.0 que comprendió un análisis descriptivo y bivariado donde se ejecutaron pruebas como Chi2 y el test exacto de Fisher, según correspondiera, con el fin de estudiar la relación de las variables.Resultados: se encontró que el 52,7% de los participantes presentaron cinco signos del SCK.Conclusión: más de la mitad de los participantes presentaron signos del SCK, encontrádose como factores asociados la presencia de prótesis total en el maxilar superior, la ausencia de prótesis en el maxilar inferior y el edentulismo parcial en el maxilar inferior.
Contaminación cruzada por el uso de tubos de resinas compartidos en las clínicas odontológicas de la Universidad Santo Tomás, Floridablanca
Authors: Niño Duarte David Felipe , Niño Ortiz Melissa Tatiana , Ortega Torres Paula Andrea , Peña Hernández Jairo Andrés , Picón Peña Jairo Fernando
Published: December 2018

Objetivo: determinar la contaminación cruzada producida por el uso de tubos de resina condensable compartidos entre pacientes por los estudiantes en las Clínicas Odontológicas de la Universidad Santo Tomás Campus Floridablanca.Materiales y métodos: estudio observacional In vitro, en el que se usaron 39 tubos de resina 3M del sector posterior de referencia (P60), con disponibilidad de los colores B2, A2 y A3 utilizados entre pacientes en las Clínicas Odontológicas de la Universidad Santo Tomás Campus Floridablanca, de séptimo a décimo semestre durante el segundo período del año 2014. Estos tubos están distribuidos: 13 por cada piso y se tomaron muestras de la resina que contenían para luego ser analizados mediante pruebas de laboratorio con el fin de establecer la presencia de microorganismos, además de identificar los microorganismos encontrados causantes de la contaminación.Resultados: el 50% de las muestras resultaron contaminadas con 15 microorganismos principales y tres secundarios.Conclusión: el porcentaje de muestras contaminadas es significativo, lo que indica que existe contaminación al momento de manipular las resinas.
Tomografía computarizada de haz cónico, una imagen diagnóstica de alta resolución en endodoncia
Authors: Duarte Martha Lucely , Blanco Bibiana Yorley
Published: December 2018

La tomografía computarizada de haz cónico es un examen diagnóstico que utiliza un scanner para obtener imágenes en tercera dimensión, los parámetros más relevantes que se deben tener en cuenta en el equipo son: el tamaño del campo visual, tiempo de exposición, voltaje de corriente del tubo y grados de rotación del cabezote alrededor del paciente. Esta técnica permite observar imágenes en tres planos, reduciendo la superposición de estructuras anatómicas, identificando con detalle la morfología interna del diente, alteraciones como perforaciones, zonas de reabsorción, lesiones periapicales, fracturas radiculares y la identificación de lesiones de origen no odontogénico. Entre sus desventajas se encuentra resolución espacial baja, dispersión y endurecimiento del haz por la presencia de estructuras metálicas como coronas, implantes y núcleos intrarradiculares. Es importante resaltar que una imagen en tres dimensiones brinda mayor fiabilidad y seguridad para el diagnóstico, tratamiento y pronóstico del tratamiento de endodoncia.