bluuebunny/crossref_metadata_2025 huggingface dataset:
Endophytic fungi from Dichrocephala integrifolia: Diversity, antifungal properties, enzymatic activities, and plant growth promotion
Authors: NONGTHOMBAM KISTU SINGH , MUTUM SHYAMKESHO SINGH , PANDEY RADHA RAMAN
Published: October 2024

Dichrocephala integrifolia is a wild medicinal plant utilised in traditional healing and Ayurveda to cope up with several health issues by various groups of people around the world. Medicinal plants are associated with diverse fungal endophytes with potential bioactive properties. In this investigation, 26 fungal endophytes were isolated from D. integrifolia and three sterile forms using the Petri plate culture method. The endophytic isolation rate was highest for inflorescence (35.97%) and lowest for stem (15.61%). The highest colonization frequency was shown by F. solani (8.37%) and the lowest by Sterile morphotype 3 (1.36%). Out of the four plant parts, inflorescence was found to be highly infected, displaying an infection rate of 93.43% and the least infection occurred in the stem with 45%. The maximum number of isolated endophytic fungi belongs to the class Sordariomycetes, with a relative occurrence (%) of 71.72%. The Simpson’s diversity index reveals that the leaf endophytes were more diverse (0.94). Qualitative antifungal activity of the sporulating isolates against Curvularia lunata has shown that the maximum number of endophytes possessed Class 3 antagonism. Four isolates were selected based on screening of their antagonistic activity and their antifungal inhibition was calculated against nine fungal phytopathogens. Maximum inhibition (100%) was shown by Trichoderma sp. 2 (S2B2) against Alternaria alternata, A. brassicicola, Colletotrichum capsici, C. lunata, and Ustilaginoidea virens and least inhibition by Gliocladium sp. 1 (19.78%) against C. lunata. The four isolates were found to produce protease, lipase, amylase and cellulase enzymes. The isolates produced ammonia and hydrogen cyanide, but none of the isolates could solubilize phosphate. Potent biocontrol agents are much needed to replace synthetic chemicals and restore soil microflora.
Exploration of three native strains of entomopathogenic fungi against rice yellow hairy caterpillar, Psalis pennatula (Lepidoptera: Lymantriidae): An emerging pest of rainfed rice in Assam
Authors: SAHA NIKITA , DAS PURNIMA , USHASRI BANNA , SAIKIA P. , DAS K.
Published: October 2024

Rice yellow hairy caterpillar Psalis pennatula Fabricius (Lepidoptera: Lymantriidae) is an emerging pest of rice and an increased incidence is expected in different rice-growing areas of Assam in the coming years. The caterpillar is a voracious leaf feeder and can consume the whole leaves within a day. Keeping this in view, an attempt was made to evaluate the bio-efficacy of three important native isolates of entomopathogenic fungal strains viz. Beauveria bassiana (KR855715), Cordyceps javanica (OM321438) and Isaria fumosorosea (MH414514) against P. pennatula larvae under laboratory conditions during the Sali season of rice. All three EPF strains at different conidial dilutions (1x103, 1x105,1x107, 1x108 and1x109 conidia/ml) were found to be pathogenic to the 3rd instar larvae of P. pennatula. Among the tested fungal strains, the strain Isaria fumosorosea (MH414514) showed the highest mortality (100%) at 1x107 conidia/ml and Cordyceps javanica (OM321438) showed the lowest mortality (51%) at 1x107conidia/ml at 10th day of post-treatment. The tested fungal isolates could play a vital role as microbial biopesticides in suppressing the P. pennatula population in Assam and could be incorporated into IPM strategies.
Validation of molecular markers linked to bruchid resistance in green gram (Vigna radiata)
Authors: SURYA M. , JAYAMANI P. , MANJU DEVI S.
Published: October 2024

The pulse beetle, Callosobruchus spp., poses a threat to legumes by consuming the protein content of the grain, resulting in potential losses in storage ranging from 12 to 30%. Molecular marker technology helps to mitigate the breeding constraint in the development of bruchid resistance in green gram breeding programmes. In the present study, validation of locus-specific STSbr1 and STSbr2 markers linked with bruchid resistance was done using fifteen genotypes viz., VBN (Gg) 2 (susceptible) and Vigna radiata var. sublobata/2 (resistant), F1 hybrid, two susceptible and ten resistant RILs derived from the above parents. The marker STS br1 behaved as a dominant marker and produced an approximate allele size of 225 bp in the resistant parent, F1 hybrid and resistant RILs and absent in susceptible parent and susceptible RILs, which showed cent per cent co-segregation with bruchid resistance locus. Hence, it is concluded that STS br1 is linked with bruchid-resistant genes. The marker STS br2 behaved as a co-dominant marker and produced an approximate allele size of 470 bp in all the 15 genotypes evaluated (monomorphic) and did not differentiate the resistant and susceptible genotypes. The marker STS br1 could be used in marker-assisted selection to develop bruchid-resistant varieties and to screen the germplasm to identify bruchid-resistant donors in green gram.
Carbon monoxide refines ovarian structure changes and attenuates oxidative stress via modulating of heme oxygenase system in a rat model of polycystic ovary syndrome: An experimental study
Authors: Asadi Bahareh , Rakhshan Kamran , Ranjbaran Mina , Abdi Arash , Vaziripour Maryam , Seifi Behjat
Published: October 2024

Background: Carbon monoxide (CO), influences ovarian function, pregnancy, and placental health. Heme oxygenase (HO)-1 and its products, including CO, exhibit protective and anti-inflammatory properties.
Objective: This study investigates the protective effects of CO released by the carbon dioxide-releasing molecule (CORM)-2 against oxidative stress, functional and structural changes of the ovaries, and HO-1 expressions in female rats suffering from polycystic ovary syndrome (PCOS).
Materials and Methods: In this experimental study, 24 Rattus norvegicus var. Albinus female rats (180–200 gr, 8 wk) were randomly divided into 4 groups (n = 6/each): control, CORM-2 (10 mg/kg), PCOS (induced by 4 mg/kg, intramuscular injection and a single dose of estradiol valerate), PCOS + CORM-2. Ovary histological changes were evaluated by crystal violet staining. Malondialdehyde (MDA) level and superoxide dismutase (SOD) activity of ovarian tissue were assessed using enzyme-linked immunosorbent assay. HO-1 expression was evaluated using Western blot.
Results: Corpus luteal formation significantly decreased in the PCOS group and was significantly restored with CORM-2 administration compared to the control group (p < 0.05). The expression of ovarian HO-1 protein was reduced in the PCOS group compared to controls (p < 0.01), and administration of CORM in PCOS rats significantly increased its expression (p < 0.0001). In addition, CORM administration markedly reduced ovarian MDA levels and restored SOD activity (p < 0.0001).
Conclusion: CORM-2 administration to PCOS rats created protective effects by reducing oxidative stress (reducing MDA level and restoring SOD activity) and increasing ovarian HO-1 protein.
Key words: PCOS, Rat, Oxidative stress, Heme oxygenase, CORM.
Prolegómenos acerca de la idea de los estereotipos en diseño
Authors: Matarrese Marina , Vilchis Esquivel Luz del Carmen
Published: October 2024

En el presente Cuaderno del Centro de Estudios en Diseño y Comunicación, reflexionamos acerca de la relación entre los estereotipos y los diseños.
El constructo social de los estereotipos femeninos dentro de los campos laborales de las diseñadoras mexiquenses
Authors: Villar García María-Gabriela , Maldonado Reyes Ana Aurora , Mora Cantellano María del Pilar Alejandra
Published: October 2024

Este trabajo pretende generar un diálogo sobre la construcción social de los estereotipos femeninos en los ámbitos laborales de las diseñadoras gráficas e industriales, particularmente en el Estado de México, para distinguir cómo el imaginario creado históricamente está arraigado en la cultura como un constructo social que deviene de una tradición compartida.
La construcción de imágenes mentales y de estereotipos en el acto de diseñar. Formas de vinculación entre diseñadores y no diseñadores
Authors: Ceja Bravo Liliana , Ceja Bravo Leobardo Armando
Published: October 2024

Los estereotipos son construcciones de imágenes mentales que los individuos crean unos de otros.
El mensaje masónico de Le Corbusier
Authors: Dradi Serena
Published: October 2024

La presente investigación indaga en el discurso de Charles Édouard Jeanneret Gris (1887-1965)
Habitar, Construir y Narrar Mundos Virtuales. Construcción de Narrativas en Minecraf
Authors: Gregor Noelia Soledad
Published: October 2024

El presente artículo explora la intersección entre el diseño arquitectónico, el diseño de experiencias y la semiótica en el contexto del videojuego Minecraf.
Pantallas en transición: del discurso analógico a lo digital en los estereotipos del envejecimiento femenino
Authors: Marenco Lucas
Published: October 2024

El artículo examina cómo el discurso televisivo ha evolucionado en la generación de estereotipos edadistas sobre la mujer
Usos de los archivos fotográficos históricos en la enseñanza básica regular en Perú post pandemia
Authors: Segovia Rojas Rita
Published: October 2024

Como parte de las capacitaciones de formación continua desde la Facultad de Educación de la Pontificia Universidad Católica del Perú (PUCP)
“Este auto no está en venta”: historia, agencia y biografía de un Volkswagen escarabajo
Authors: Torres Rebaza Licia , Juárez Li Jorge
Published: October 2024

El presente estudio se centra en la biografía de un objeto, un Volkswagen modelo escarabajo, cuya popularidad tuvo su auge en las décadas de 1980 y 1990 en el Perú y parte de un marco antropológico de la cultura material y el diseño.
Effect of Bypass Fat on Genital Status and Blood Biochemical Profiles in Pubertal Swamp Buffalo Heifers and Puerperal Swamp Buffalo Cows
Authors: Deka N. , Nath K.C. , Bhuyan M. , Saikia B.N. , Das G.C. , Dutta L.J. , Deka R.
Published: October 2024

Background: The interaction between nutrition and reproduction has long been known to have important implications for the reproductive performance in animal.The present study highlights the effect of by-pass fat supplementation on genital changes and blood biochemical profile in pubertal swamp buffalo heifers and puerperal swamp buffalo cows. Methods: 24 heifers of 2-2.5 years of age and 24 puerperal cows on the day of parturition, irrespective of parity were used as experimental animal. The analytical method was based on the treatment protocols of 3 groups in both heifers and cows (n=8 in each group) viz., treated with oral bypass fat alone (I), oral bypass fat, mineral mixtures and injectable phosphorus (II) and control (III) respectively. Genital status, metabolic hormone (leptin, Ghrelin and IGF-1), reproductive hormone (estrogen and progesterone) and mineral constituents (calcium, phosphorus, zinc and copper) were analyzed on day 0, day 15 and day 30 in heifers and day 15, day 30 and day 45 in cows respectively. Result: Feeding of bypass fat alone or bypass fat fortified with minerals and injectable phosphorus was not found to induce significant genital changes in heifers and cows. The serum leptin and IGF-1 levels were increased significantly (p less than 0.05) in heifers at day 30 in Group I and II. However, a significant rise (p less than 0.05) of leptin was recorded at day 45 in group I and II cows. IG1-1 level was recorded increased significantly only in cows treated with fortified bypass fat (Group II). With the progression of treatment the serum phosphorus level was increased significantly (p less than 0.05) in Group I and II cows. Serum estrogen levels were increased in both heifers and cows with progression of treatment in both Group I and II. However, serum progesterone levels were increased significantly only in heifers of Group I and II with progression of treatment.
suscetibilidade às inundações em extremos climáticos
Authors: Veiga Maria Eduarda Barbosa da , Simões Matheus Batista , Barros Filho Mauro Normando Macêdo , Galvão Carlos de Oliveira
Published: October 2024

A urbanização crescente, quando desarticulada do planejamento do uso e ocupação do solo e associada a eventos extremos de precipitação decorrentes das mudanças climáticas, pode levar a desastres como inundações e alagamentos. Este artigo propõe a utilização de análise multicriterial para produção do mapa de suscetibilidade às inundações e aos alagamentos com base em métricas de morfologia urbana, com o objetivo de compreender como as diversas métricas morfológicas influenciam a geração do escoamento. O método é aplicado em uma bacia urbana com padrões morfológicos heterogêneos, localizada na cidade de Campina Grande, Paraíba. O mapa final produzido, validado por simulação hidrológica de um evento extremo, demonstrou que as métricas da morfologia urbana podem ser consideradas na formulação das estratégias de adaptação às mudanças climáticas.
Calidad Higiénica De Ventas Informales De Queso Fresco Artesanal En El Mercado Público De Barranquilla, Colombia
Authors: Navas Guzman Norleyn Maria , De la Rosa Barrios Laura , Ruiz Arrieta Milena , Ballesta Rodríguez Ingrid , Peluffo Rivera Angélica
Published: October 2024

El queso fresco artesanal es producido a partir de leche cruda bajo condiciones que favorecen la contaminación microbiana y comercializado en puntos de venta ubicados en la vía pública en los cuales se presentan deficiencias en las prácticas de higiene representando un riesgo de transmisión de enfermedades alimentarias. El objetivo de este estudio fue evaluar la calidad higiénica de ventas informales de queso fresco artesanal en el mercado público de Barranquilla. Se evaluaron 22 puestos de ventas aplicando un perfil sanitario basado en la Resolución 604 de 1993 del Ministerio de Salud. Se determinó Escherichia coli y Staphylococcus aureus en muestras de queso. Se evidenció vestimenta inadecuada, ausencia de lavado de manos, presencia de animales, basuras en los alrededores, aguas estancadas y rompimiento de la cadena de frio en el almacenamiento. El 90.9% y 100% de las muestras de queso presentaron valores aceptables para Escherichia coli y Staphylococcus aureus respectivamente.
Anillo no local inmerso en producto de cuerpos
Authors: Granados Pinzón Claudia , Contreras-Mendoza Astrid L. , Olaya-Le´on Wilson
Published: October 2024

En este artículo estudiamos la inmersión de R, un anillo conmutativo con unidad no local, en un productodirecto de cuerpos. En el producto de los cuerpos cocientes de R dados por sus ideales maximales. Elhomomorfismo ϕ de R en el producto directo de cuerpos cocientes está definido por la propiedad universaldel producto y su núcleo es Kerϕ = J (R), donde J (R) es el radical de Jacobson de R. Si J (R) = {0},el homomorfismo es inyectivo en el caso infinito, y en el caso finito probaremos que ϕ es un isomorfismo.Además, consideramos el caso donde R es un anillo total de fracciones con un número finito de idealesmaximales y mostraremos que el homomorfismo de R en el producto de sus localizados es inyectivo. Másaún, si R es de la forma Zn, con n ̸= 0, o R es una K−álgebra finita, con K un cuerpo, tenemos que estehomomorfismo es un isomorfismo.
Control De Spodoptera Frugiperda Mediante Insecticida Aplicado Con Drones Y Aguilón Fumigador
Authors: Zhiminaicela Cabrera Jonathan Bladimir , Herrera-Reyes Sayda , España Valencia Paola
Published: October 2024

En este estudio se evaluaron diferentes tratamientos y métodos de aplicación para el control de plagas en el cultivo de maíz. Se analizaron variables como el porcentaje de incidencia de la plaga, el grado de infección del cultivo según la escala DAVIS y el número de larvas a diferentes días de aplicación. Los resultados mostraron que los tratamientos con dosis de 200 cc/ha, ya sea aplicados mediante DRON o de forma convencional, fueron los más efectivos en términos de incidencia de la plaga y grado de infección del cultivo. A los 5 días de aplicación, se observó una disminución significativa en el número de larvas en los tratamientos con dosis de 200 cc/ha aplicados mediante DRON. Sin embargo, a los 7 y 10 días, se registró un incremento moderado en el número de larvas en todos los tratamientos. Además, se encontró que la aplicación mediante DRON permitió una mejor dispersión del producto y una mayor cobertura en el área tratada. Estos hallazgos resaltan la importancia de considerar la dosis y el método de aplicación para lograr un control eficaz de las plagas en el cultivo de maíz.
Resiliencia socioecológica en agro-ecosistemas agrícolas en Sumapaz Cundinamarca
Authors: Fonseca Carreño Nelson Enrique , Fonseca Carreño Jorge Armando
Published: October 2024

Se evalúo la resiliencia socio-ecológica en 20 agroecosistemas en Sumapaz Cundinamarca mediante la tipificación de indicadores de Amenaza, Vulnerabilidad y Capacidad de respuesta, según las prácticas de base agroecológica que allí se implementan. Se utilizó el concepto de Índice Holístico de Riesgo, para evaluar el nivel de resiliencia socio-ecológica bajo criterios biofísicos y socioeconómicos y el Test de Wilcoxon para contrastar diferencias entre sistemas agroecológicos y convencionales donde valores p < 0.05 muestran la diferencia. Por lo tanto, el grado de resiliencia se estimó a través de 21 indicadores, se presentan 8 con valores > 1 que no favorecen condiciones de resiliencia y 13 =< 1 que son favorables. El índice de riesgo presenta sistemas agroecológicos con valores 3.1 ± 5.0 y convencionales con valores de 0.7 ±1.9, lo que demuestra una alta vulnerabilidad. {\displaystyle {\overline {x}}}Se concluye que existe una transición hacia sistemas agroecológicos que reducen energía, recursos y resisten a perturbaciones y alteraciones de tipo antrópico.
PRODUCTION OF A PROTEIN ISOLATE FROM BOYACENSE QUINOA FLOUR (Chenopodium quinoa) BY COMBINED METHODS
Authors: Niño bernal Ivan
Published: October 2024

La quinua es un pseudocereal que es conocido por su alto contenido de proteína vegetal. El presente estudio se enfocó en obtener un aislado proteico, utilizando diferentes metodologías de extracción. La caracterización inicial de la harina de quinua en base seca (QF) mostró un contenido de proteína del 16 % y de almidón del 53 %. Se establecieron los mejores valores de pH, a través de curvas de solubilidad, y se llevaron a cabo extracciones en soluciones 0 % y 1 % de NaCl, obteniendo un rendimiento del 38 % de proteína. Posteriormente, se empleó una extracción fraccionada, lo que permitió aumentar el rendimiento proteico al 42 %. Por último, se aplicó una hidrólisis enzimática del almidón presente en la harina, que actúa como interferente en la extracción proteica. El uso combinado de la hidrólisis enzimática y la extracción fraccionada permitió obtener un aislado proteico con un alto porcentaje de pureza (~55 %). Este estudio demostró que la combinación de diferentes metodologías de extracción puede mejorar significativamente el rendimiento y pureza del producto final.
Numfracpy, Técnicas del C´álculo Fraccionario en Python
Authors: López Melo Jorge Hernán
Published: October 2024

En este trabajo se introduce una librería en el lenguaje Python que implementa técnicas propias del cálculofraccionario. Este tipo de cálculo ha visto un incremento notable de sus aplicaciones en diversas áreas delas ciencias en las últimas décadas. Sin embargo, el tipo de cálculos que se necesitan para su desarrollo noson simples y no hay muchas ayudas computacionales para su implementación, especialmente en Python.Numfracpy se encuentra disponible al público en el índice de paquetes PyPI (Python Package Index) eimplementa diversos conceptos del cálculo fraccionario como lo son: La integral y la derivada de Riemann-Liouville, la derivada de Caputo, la derivada de Grünwald-Letnikov, las funciones de Mittag-Leffler, lasolución numérica de un tipo de ecuación diferencial en derivadas fraccionarias y un sistema de talesecuaciones diferenciales. En este trabajo se presentan varios algoritmos implementados y los resultadosobtenidos se comparan con aquellos reportados en la literatura, encontrando una buena aproximación en losdiferentes ejemplos ilustrados.
Aprender a bailar tango:
Authors: Montero González Martha Soledad , Duarte López Ilusión Rita María , Cifuentes Medina José Eriberto , Ríos Padilla Joséphine Aruma , Córdoba Reyes Fabián , Sierra Jerónimo Manuel , Diego Juan
Published: October 2024

El Grupo de investigación Filosofía, Educación y Pedagogía avalado por la Universidad Pedagógica y Tecnológica de Colombia – UPTC, con sede en la ciudad de Tunja, departamento de Boyacá, convocó, a través, de la línea de Estética y Educación artística a la comunidad de la Región Andina Colombiana, entre los años 2016 y 2021, por fuera del aula de clase, sin distinción de edad, sexo, religión, raza, género, ideología y proveniencia social o económica a participar en el proceso de aprender a bailar tango, con el objetivo de experimentar el baile del abrazo por el baile mismo, y lo que este es capaz de hacer sobre cuerpos colectivos y en pareja transportando sensaciones que se vuelven movimiento y sonoridad.Los objetivos específicos correspondientes a cada una de las cuatro fases estructurantes del proceso tenían que ver, en primer lugar, con aprender a bailar por el baile mismo del tango; en segundo lugar, poner en relación personas de distintas generaciones y experimentar el abrazo en el aprendizaje del baile sin caer en el estereotipo, en tercer lugar, construir una obra y, en cuarto lugar, reconstruir el proceso de experimentación para la apropiación social del conocimiento, las cuales, se presentan a lo largo de este libro resultado de investigación con el objeto de extraer del proceso de experimentación una determinada manera de aprender a bailar. Esto es, iniciar y continuar con la construcción de un proceso de enseñanza y de aprendizaje que tuvo como punto de partida el esfuerzo por desarrollar la experiencia colectiva e individual en el recorrido mismo.Por lo anterior, para presentar lo que pasó en este proceso de aprender, se acude a organizar el libro en tres capítulos, para dar cuenta del resultado de las variaciones que trazaron la trayectoria de cada pieza que los produjo, y que orientó la reconstrucción escrita del proceso al romper con la idea y la creencia de que sabemos lo que pueden los cuerpos cuando se abrazan. Este proceso tuvo como punto de partida, el esfuerzo por construir la experiencia de innovación social, colectiva e individual, para potenciar en la dirección que señala Spinoza, lo que el hombre puede, es decir, aquello, que es capaz de hacer y qué pruebas puede soportar en la perspectiva de crear una obra inédita y colectiva de teatro-danza, más allá del aprender virtuoso y profesional del tango como espectáculo.El proceso del aprender en términos metodológicos se aleja de investigaciones cualitativas y cuantitativas, de corte científico y de medición, para privilegiar la experimentación y la experiencia propia en el proceso mismo de apropiación, cuyo resultado final es la reconstrucción de tal proceso único.
Implementation of mutual insurance “against fire” of buildings of the ecclesiastical department in Russia in 1910-1917 (based on materials from the Ust-Sysolsk Uyezd of the Vologda province)
Authors: Rozhina A.
Published: October 2024

The paper deals with the study of the pre-revolutionary experience of mutual insurance against fires of real estate of the Russian Orthodox Church. Based on financial and office documents of the Ust-Sysolsk Uyezd of the Vologda province, the process of practical implementation of insurance of buildings of the ecclesiastical department on the principles of reciprocity is recreated.
The regulatory framework for mutual insurance was based on the legislative act of 1904, but the insurance assessment of buildings was carried out only in 1910. Information is provided on the structure of insurance documents, cases of fires and payments for damage “from fire” from sources deposited in the funds of the Russian State Historical Archive. By January 1, 1911, diocesan buildings in the Russian Empire were insured for over 800 million rubles, in the Ust-Sysolsk Uyezd – for over 859 thousand rubles. Information on the number of insured buildings and their insurance assessment, the amount of annual premiums and compensations for insurance cases in the Ust-Sysolsk Uyezd is systematized. The analyzed materials made it possible to correlate insurance premiums and insurance business costs, to access both the negative aspects and the benefits of mutual insurance for policyholders.
The author comes to the conclusion that the practices of mutual real estate insurance, organized by the Holy Synod, demonstrate valuable experience in finding solutions to eliminate material damage “from fire”, when fire losses were compensated through small contributions. Insurance on the principles of rerciprocity was most important for regional parishes, that did not have large incomes and were often unable to independantly restore destroyed buildings. Due to compensations, it was possible to repair and restore many buildings of the ecclesiastical department. Despite bureaucratic, travel, and clerical expenses for insurance business, the remaining funds allowed to form a “reserve capital”, that performed the function of a reserve fund.
The Role of Sharia Financial Inclusion in MSME Development in Sumenep (Study at BPRS Bhakti Sumekar)
Authors: Angraini Yeni , Zakik
Published: October 2024

This research is intended to identify and evaluate the contribution of Sharia financial inclusion at Sharia People's Financing Bank Bhakti Sumekar to the development of MSMEs in Sumenep Regency with the dimensions of accessibility, use of products and services, and service quality. This study determined sample size followed the Roscoe formula. At least 40 MSMEs were customers of Sharia People's Financing Bank Bhakti Sumekar were obtained. To collect data, a combination of interview methods and questionnaire distribution were used. The data was analyzed using SPSS for instrument testing, descriptive statistics, multiple linear regression, classical assumption testing, and hypothesis testing. Results showed that simultaneously, the variables of accessibility, use of products and services, and service quality have a significant impact on the development of MSMEs. However, partial use of products and services does not have a big impact on the development of MSMEs. This is partly due to the limited public awareness regarding Sharia financing, as well as the frequent misuse of credit financing. The implications of this research can provide direct benefits of Islamic financial inclusion, such as easier access to financing, better financial management, and increased business capacity. This will ultimately contribute to improved MSME performance, regional economic growth, and community welfare.
Assessing the 9G Technology Blood Test for Predicting Lung Cancer in Patients with CT-Detected Lung Nodules: A Multicenter Clinical Trial
Authors: Kim So Yeon , Park Young Sik , Kim In Ae , Kim Hee Joung , Lee Kye Young
Published: October 2024

Lung nodules detected by chest computed tomography (CT) often require invasive biopsies for definitive diagnosis, leading to unnecessary procedures for benign lesions. A blood-based biomarker test that predicts lung cancer risk in CT-detected nodules could help stratify patients and direct invasive diagnostics toward high-risk individuals. In this multicenter, single-blinded clinical trial, we evaluated a test measuring plasma levels of p53, anti-p53 autoantibody, CYFRA 21-1, and anti-CYFRA 21-1 autoantibody in patients with CT-detected lung nodules. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated, and subgroup analyses by gender, age, and smoking status were performed. A total of 1,132 patients who had CT-detected lung nodules, including 885 lung cancer cases and 247 benign lesions, were enrolled from two academic hospitals in South Korea. The test demonstrated a sensitivity of 78.4% (95% CI: 75.7-81.1) and specificity of 93.1% (95% CI: 90.0-96.3) in predicting lung cancer in CT-detected nodules. The PPV was 97.6%, and the NPV was 54.6%. Performance was consistent across gender (sensitivity 79.3% in men and 76.8% in women) and age groups, with a specificity of 93.4% in men and 92.7% in women. Stage I lung cancer was detected with a sensitivity of 80.6%. The lung cancer test based on 9G technology presented here offers a non-invasive method for stratifying lung cancer risk in patients with CT-detected nodules. Its integration into clinical practice could reduce unnecessary interventions and foster earlier detection.
Superior Adsorption of Chlorinated VOC by Date Palm Seed Biochar: A Two-Way ANOVA Comparative Analysis with Activated Carbon
Authors: Remmani Rania , Papini Marco Petrangeli , Amanat Neda , Canales Antonio Ruiz
Published: October 2024

This study investigates biochar (BC) derived from date palm seeds as a high-performance ad-sorbent for trichloroethylene (TCE) and tetrachloroethylene (PCE) removal from aqueous solu-tions, comparing its efficacy to commercial activated carbon (AC). The optimized BC exhibits a high BET surface area of 654.79 m²/g and a unique nanotube morphology. Kinetic studies indicate that the pseudo-second-order model best describes the adsorption process, with BC achieving capacities of 86.68 mg/g for TCE and 85.97 mg/g for PCE, significantly outperforming AC. Isotherm analysis suggests a complex adsorption mechanism involving both multilayer and monolayer adsorption. Two-way ANOVA confirms the significant superiority of BC over AC (p < 0.0001) for both CVOCs. The enhanced performance of BC is attributed to its high surface area, well-developed microporosity, and advanced surface chemistry. This study highlights the promise of date palm seed-derived biochar as a sustainable, high-performance adsorbent for eco-friendly water treatment solutions, potentially reducing operational costs and environmental impact in real-world applications.
Natural History and Risk Factors of Hymenoptera Venom Allergy in Dogs
Authors: Chapman Edwin , West Erin Ashley , Kosnik Mitja , Fischer Nina Maria , Favrot Claude , Beeler Leo , Rostaher Ana
Published: October 2024

Hymenoptera, which includes honeybees, wasps, bumblebees, and hornets, is an order of the class Insecta whose venom can induce anaphylactic reactions in dogs. While several studies have investigated the natural histories and risk factors of Hymenoptera venom allergy (HVA) in humans, only limited information is available on canine patients. Therefore, the aim of this study was to identify risk factors leading to severe systemic reactions (SSR) and to explore the natural history of these patients. This was achieved with an inquiry into the case histories of 178 dogs that were stung by Hymenoptera between 2018 and 2022. Dogs under two years old, dogs that weighed under 10kg, purebred dogs and dogs that were stung in the oral cavity were at a greater risk of developing SSR. Almost two thirds of patients with SSR experienced the same or worse symptoms after subsequent stings and > 40% of patients with local reactions developed SSR when stung again. Next to providing valuable clinical information of HVA in dogs, these findings strongly support the recommendation of venom immunotherapy (VIT) for patients with HVA.
Introducing the Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations. I: Mathematical Framework
Authors: Cacuci Dan Gabriel
Published: October 2024

This work introduces the mathematical framework of the novel “First-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations” (1st-FASAM-NODE). The 1st-FASAM-NODE methodology produces and computes most efficiently the exact expressions of all of the first-order sensitivities of NODE-decoder responses with respect to the parameters underlying the NODE’s decoder, hidden layers, and encoder, after having optimized the NODE-net to represent the physical system under consideration. Building on the 1st-FASAM-NODE, this work subsequently introduces the mathematical framework of the novel “Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations (2nd-FASAM-NODE).” The 2nd-FASAM-NODE methodology yields and computes most efficiently the exact expressions of the second-order sensitivities of NODE decoder-responses with respect to the NODE parameters. Since the physical system modeled by the NODE-net necessarily comprises imprecisely known parameters that stem from measurements and/or computations subject to uncertainties, the availability of the first-and second-order sensitivities of decoder responses to the parameters underlying the NODE-net are essential for performing sensitivity analysis and quantifying the uncertainties induced in the NODE-decoder responses by uncertainties in the underlying uncertain NODE-parameters.
Novel Calcitonin Gene-Related Peptide (CGRP) Interfering Migraine Therapies and Stroke – A Review
Authors: Eller Michael Thomas , Frank Florian , Kaltseis Katharina , Karisik Anel , Knoflach Michael , Broessner Gregor
Published: October 2024

Migraine and stroke are neurological disorders with significant global prevalence and impact. Recent advances in migraine therapy have focused on calcitonin gene-related peptide (CGRP) pathway. This review examines the shared pathomechanisms between migraine and stroke, with emphasis on the role of CGRP. We analyze current literature on CGRP's functions in cerebrovascular regulation, edema formation, neuroinflammation, and neuroprotection. CGRP acts as a potent vasodilator and plays a crucial role in trigeminovascular activation during migraine attacks. In stroke, CGRP has demonstrated neuroprotective effects by improving collateral circulation and reducing ischemia-reperfusion injury. Concerns have been raised about the potential impact of CGRP inhibsitors on stroke risk and outcomes. Studies in animals suggest that CGRP receptor antagonists may worsen cerebral ischemia by impairing collateral flow. We discuss the implications of these findings for the use of CGRP-targeting therapies in migraine patients, especially those at increased risk of stroke. Additionally, we explore the complex interplay between CGRP, endothelial function, and platelet activity in both conditions. This review highlights the need for further research to elucidate the long-term cerebrovascular safety of CGRP pathway inhibitors and to identify potential subgroups of migraine patients who may be at higher risk of adverse cerebrovascular events with these novel therapies.
A Fully-Autonomous on-Board GNC Methodology for Small-Body Environments Based on Convolutional Neural Network (CNN) Image Processing and Model Predictive Control (MPC)s
Authors: Peñarroya Pelayo , Escalante Alfredo , Frekhaug Thomas , Sanjurjo Manuel
Published: October 2024

The increasing need for autonomy for space exploration missions is becoming more and more relevant in the design of missions to small bodies. The long communication latencies and sensitivity of the system to unplanned environment perturbations pose autonomous methods as a key design block for this type of mission. In this work, a fully autonomous gnc methodology is introduced. This methodolody relies on published cnn-based techniques for surface recognition and pose estimation and on also existing mpc-based techniques for the design of a trajectory to perform a soft landing on an asteroid. Combining hda with relative navigation systems, a gsm is built on-the-fly as images are acquired. These gsms provide the gnc system with information about feasible landing spots and populate a longitude-latitude map with safe/hazardous labels that are later processed to find an optimal landing spot based on mission requirements and a distance-from-hazard metric. The methodology is exemplified using Bennu as the body of interest and a gsm is built for an arbitrary reconnaissance orbit.
Is Celiac Trunk Revascularization Necessary after High-Flow Pancreaticoduodenal Arterial Arcades Aneurysm Retrograde Embolization?
Authors: Jazzar Mohamed Salim , Kobeiter Hicham , Ghosn Mario , Amar Raphael , Zaarour Youssef , Galletto Pregliasco Athena , Desgranges Pascal , Tacher Vania , El Hajjam Mostafa , Derbel Haytham
Published: October 2024

Background: High-flow pancreaticoduodenal artery (PDA) aneurysms secondary to celiac trunk occlusion or stenosis have a high risk of rupture. Embolization offers a less invasive alternative to surgery. Objective: To evaluate the effectiveness and safety of retrograde embolization via the superior mesenteric artery of high-flow PDA aneurysms without celiac trunk revascularization. Methods: This retrospective bicentric study included patients who underwent embolization of high-flow PDA aneurysms due to significant celiac trunk stenosis or occlusion. All patients underwent pre-interventional dynamic contrast-enhanced computed tomography. Retrograde embolization was performed using microcoils and/or liquid agents without celiac trunk revascularization. Follow-up involved clinical and radiological assessment at one month. Technical and clinical success were evaluated, and complications were categorized as minor or major. Results: Twenty-three patients (mean age: 65 ±14 years; 52% male) were included. Emergency embolization was required in 12 patients (52%). The technical success rate was 100%. Patients were monitored for a median of 16 months. Clinical success was 87%. No hemorrhagic recurrences were observed. Minor complications occurred in two cases. One major complication involved splenic infarction due to glue migration, requiring splenectomy and intensive unit care admission. Conclusion: Retrograde embolization of high-flow PDA aneurysms is effective and safe without needing celiac trunk revascularization.
Innovative Diagnostic Solutions in Hemostasis
Authors: Favaloro Emmanuel J , Pasalic Leonardo
Published: October 2024

Hemostasis describes the process of blood clotting homeostasis. Hemostasis reflects a balance of procoagulant and anticoagulant mechanisms that aim to prevent both bleeding and thrombosis. If hemostasis is disrupted, and bleeding or thrombosis occur, then laboratory testing may ensue to either diagnose the reason for bleeding or thrombosis, or to manage patients under therapy or treatment for bleeding or thrombosis. A wide range of tests of hemostasis are available to laboratories and to clinicians from routine coagulation assays like prothrombin time (PT) and activated partial thromboplastin time (APTT) to specialized assays for von Willebrand factor (VWF) and platelet function. In the current narrative review, we highlight some of the history of innovative diagnostic solutions such as the integration of chemiluminescence and flow cytometry in the hemostasis diagnostic armamentarium, as well as providing a glimpse to the possible future of diagnostic hemostasis testing. This review also emphasizes the importance of harmonization and standardization in hemostasis testing to reduce variability and improve diagnostic accuracy. Future directions include the potential for artificial intelligence in diagnostics, the development of more global test systems that can assess both primary and secondary hemostasis, and the innovations required to follow continuous evolution of therapies requiring precise monitoring. This review underscores the ongoing need for innovation to enhance the diagnostic landscape of hemostasis, ensuring better patient outcomes through more accurate and efficient diagnostic methods.
Association of IDH1 Mutation and MGMT Promotor Methylation with Clinicopathological Parameters in Adults with Gliomas in England
Authors: Wanis Hiba A , Moller Henrik , Ashkan Keyoumars , Davies Elizabeth Anne
Published: October 2024

Background - Molecular profiles can predict which patients will respond to current standard treatment and new targeted therapy regimens. Using data from a highly diverse population of approximately three million in Southeast London and Kent, this study aims to evaluate the prevalence of IDH1 mutation and MGMT promotor methylation in the gliomas diagnosed in adult patients and to explore correlations with patients’ clinicopathological characteristics.
Methods - Anonymised data on 749 adult patients diagnosed with a glioma in 2015-2019 at King’s College Hospital were extracted. Univariable and multivariable logistic regressions were used to estimate odds ratios (ORs) for expressing IDH1 mutation and MGMT promotor methylation, based on each patient’s age, sex, ethnicity, histology, tumour location and extent of excision. The Kaplan-Meier method was used to estimate the overall survival functions.
Results - 19.5% of cases were IDH1 mutated. Being 39 years and younger (OR 5.48, 95% CI 3.17-9.47), from Asian/Asian British background (OR 3.68, 95% CI 1.05-12.97), having MGMT methylation (OR 15.92, 95% CI 7.30-34.75), an oligodendroglioma diagnosis (OR 7.45, 95% CI 2.90-19.13) and receiving a gross total/total microscopic excision (OR 1.95, 95% CI 1.24-3.08) were each univariately correlated with IDH1 mutation. MGMT methylation association persisted on adjustment (OR 14.13, 95% CI 3.88-51.43). MGMT promotor methylation was seen in 54.3 % of gliomas. In the univariate adjusted ORs, being younger than 39 years (OR 2.56, 95% CI 1.48-4.43), female (OR 1.52, 95% CI 1.11-2.08), having IDH1 mutation (OR 15.92, 95% CI 7.30-34.75) and an oligodendroglioma diagnosis (OR 6.20, 95% CI 1.33-28.88) were associated with MGMT methylation. Being female (OR 1.75, 95% CI 1.22-2.51) and having an IDH1 mutation (OR 15.54, 95% CI 4.73-51.05) persisted after adjustment for age, sex, ethnicity, histology, tumour location and extent of excision. IDH1 mutant and MGMT methylated gliomas were associated with frontal lobe location. Survival analysis showed that patients with both IDH1 mutation and MGMT methylation had a significantly better survival than those with either molecular marker alone. Over a 3-year period, women with unmethylated MGMT promotor generally had a better survival than men with unmethylated MGMT.

Conclusion - This study showed that the molecular markers IDH1 mutation and MGMT promotor methylation were associated with age, sex, Asian/Asian British Ethnic Group, tumour histology, anatomical location and extent of excision. This study has demonstrated the importance of assessing glioma molecular markers in the clinical setting, and the need to stratify patients according to their clinicopathological characteristics.
MEGF11 Activates RAD52‐Dependent ALT through the NELL2‐PAX7 Transcriptional Cascade during Malignant Transformation of MPNSTs
Authors: Lee Jungwoo , Kim Eunji , Kim HyoJu , Kim Young-Joon , Kim Seung Hyun
Published: October 2024

Backgroud
In eukaryotes with a double-stranded linear DNA genome, the loss of terminal DNA during replication is inevitable due to an end-replication problem and telomeres serve as a buffer against DNA loss. Cumulative telomere attrition leads to replicative senescence and the Hayflick limit. Thus, activation of the telomere maintenance mechanism (TMM) is a prerequisite for malignant transformation. We show that extracellular, but not intracellular, signals activate RAD52-dependent alternative lengthening of telomeres (ALT) during malignant transformation of malignant peripheral nerve sheath tumors (MPNSTs).
Methods
We compared neurofibroma (NF, benign) and MPNST occurring in the same patient with type-1 neurofibromatosis, where each NF-MPNST pair shares the same genetic background and differentiation lineage minimizing genetic bias and contrasts only changes related to malignant transformation.
Results
We found that the MEGF11 and the MEGF11-dependent ephrin signaling pathways (EFNA5-EPHPA6-PDZD9/PARD6B) activate the NELL2-PAX7 transcriptional cascade, which sequentially activates RAD52, the recombinase of RAD52-dependent ALT, resulting in telomere elongation, metastasis, and poor prognosis. In contrast, H2AFX, a DNA damage marker and intracellular signal, activates RAD51-dependent ALT to determine the MPNST grade.
Conclusions
We demonstrated the extracellular signals that activate RAD52-dependent ALT and distinguished the biological and clinical manifestations of RAD51 and RAD52-dependent ALT during malignant transformation of MPNSTs.
Impact of Selected Eutectic Solvents on the Volatile Composition of Citrus Lemon Essential Oil
Authors: Petretto Giacomo Luigi , Mele Andrea , Pintore Giorgio , Mannu Alberto
Published: October 2024

The development of new materials for the controlled release of molecules represents a topic of primary importance in medicine as well as in food science. Herein, three eutectic systems respectively composed by choline chloride and ethylene glycol (1:2 molar ratio), methyltriphenylphosphonium bromide and ethylene glycol (molar ratio 1:5), and choline chloride and glycerol (molar ratio 1:1.5) were tested as materials for the controlled release of an essential oil derived from citrus lemon leaves.
The Future of Telemedicine: Overcoming Barriers to Widespread Adoption
Authors: ZUMANI KEBBY
Published: October 2024

Telemedicine has emerged as a transformative tool in modern healthcare, particularly during the COVID-19 pandemic, which catalyzed its rapid expansion. Despite its demonstrated potential in enhancing remote patient monitoring, AI-driven diagnostics, and telepsychiatry, widespread adoption of telemedicine remains constrained by persistent barriers. This review examines the current state of telemedicine, identifying major advancements alongside key challenges that impede its full integration into global healthcare systems. These barriers include the digital divide, regulatory inconsistencies across regions, and patient concerns about data security and the quality of virtual care. Addressing these issues requires a coordinated multi-sectoral approach, emphasizing infrastructure development, regulatory harmonization, patient education, and the incorporation of emerging technologies such as AI, blockchain, and virtual reality. By overcoming these challenges, telemedicine can be established as a cornerstone of equitable, accessible, and patient-centered healthcare worldwide.
Vertical Jump Height Estimation using Low-Sampling IMU in Countermovement Jumps: A Feasible Alternative to Motion Capture and Force Platforms
Authors: Villa Giacomo , Bonfiglio Alessandro , Galli Manuela , Cimolin Veronica
Published: October 2024

Vertical jump height is a reliable measure of lower limb functionality for countermovement jumps. Motion capture systems and force platforms are considered gold standards to assess athletes’ performance during these motions, however their use in ecological settings is limited by high costs and lack of portability. This study aimed to evaluate the feasibility of low-sampling rate Inertial Measurement Units as an alternative to gold standard systems. The validity of three computational methods for IMU-based data—Numerical Double Integration, Take-Off Velocity and Flight Time—was assessed using data from 18 healthy subjects who performed five bilateral and ten unilateral countermovement jumps. Data were simultaneously collected from an IMU positioned at the L5 level, a motion capture system, and two force platforms. Comparisons revealed that the Numerical Double Integration method exhibited the highest correlation (0.87), the lowest bias (2.5 cm) compared to gold standards, and excellent reliability (0.88). Although the Take-Off Velocity and Flight Time methods demonstrated comparable performance for bilateral jumps, their accuracy in unilateral jumps was reduced. Overall, low-sampling rate IMU with Numerical Double Integration method proves to be a reliable and portable alternative for field-based CMJs assessment, warranting future investigation across diverse populations and jump modalities.