bluuebunny/crossref_metadata_2025 huggingface dataset:
Steady Radiating Gravity waves: An Exponential Asymptotics Approach
Authors: Kataoka Takeshi , Akylas T. R.
Published: January 2024

The radiation of steady surface gravity waves by a uniform stream $$U_{0}$$

U
0

over locally confined (width $$L$$
L
) smooth topography is analyzed based on potential flow theory. The linear solution to this classical problem is readily found by Fourier transforms, and the nonlinear response has been studied extensively by numerical methods. Here, an asymptotic analysis is made for subcritical flow $$D/\lambda > 1$$

D
/
λ
>
1

in the low-Froude-number ($$F^{2} \equiv \lambda /L \ll 1$$

F
2

≡
λ
/
L
≪
1

) limit, where $$\lambda = U_{0}^{2} /g$$

λ
=

U

0

2

/
g

is the lengthscale of radiating gravity waves and $$D$$
D
is the uniform water depth. In this regime, the downstream wave amplitude, although formally exponentially small with respect to $$F$$
F
, is determined by a fully nonlinear mechanism even for small topography amplitude. It is argued that this mechanism controls the wave response for a broad range of flow conditions, in contrast to linear theory which has very limited validity.
Evaluation of C/N0 raw observation positioning by smartphone based on indoor asynchronous pseudolite
Authors: Lu Xiangchen , Chen Liang , Shen Nan , Jiang Jiahui , Dai Yue , Chen Ruizhi
Published: January 2024

With the rapid development of the economy and information services, there is an increasing demand for indoor positioning. However, Global Navigation Satellite System (GNSS) signals face difficulties in penetrating buildings, making indoor positioning challenging. As a complementary solution to outdoor GNSS signals, pseudolites have shown promising results in various scenarios, and have become one of the research hotspots in the field of indoor positioning. Previous studies on indoor positioning with pseudolites have focused on issues such as initial position determination and carrier phase ambiguity resolution. However, most of these studies have remained in the research stage due to data post-processing and complex calculations. To overcome the limitations associated with the aforementioned factors, this paper proposes a real-time indoor positioning method that utilizes only a smartphone equipped with a built-in GNSS chip. By effectively obtaining pseudolite signal information, the smartphone establishes a simple model based on the distance and received power between the pseudolite and the smartphone. Kalman filtering is employed to mitigate the effects of multipath and occlusion. This simple and low-complexity model enables fast estimation of the user's distance from the pseudolite, thereby facilitating indoor positioning services. In this paper, the effectiveness and low complexity of the method are verified through data collection and experiments in the actual scene of the underground garage. The valuation results show that the root mean square error (RMSE) of its navigation and positioning is better than 3 m, which can meet the needs of daily life applications.
Private Citizens of the World and Frontier Expansion
Authors: Antunes Madeira da Silva Filipe
Published: January 2024

In her analysis of James Lorimer's The Institutes of the Law of the Nations (1883), Karen Knop called on public international lawyers to explore the potential of Lorimer's figure of the “private citizens of the world” to illuminate the position of the individual in international law.1 She argued that focusing on the individual's private law dimension revealed hidden understandings and manifestations of the international. This focus, she observed, might even clarify the structural role that nonstate actors and their legal interactions play in shaping sovereign states and their relations.2 This essay builds on Knop's insight to reflect on the role of actors involved in frontier expansion in international law. I examine the settlement of land deemed desert in South America at the turn of the nineteenth century, as private actors used law to incorporate new territories and resources into a capitalist order. Drawing on the work of Argentinian jurist Carlos Calvo, and analyzing specific cases of settlement in the Amazon, I explain how these actors and their legal practices participated in the consolidation of a territorial order of states. Following Knop's prompt, I explore how examining the role of individuals and their private allegiances sharpens our view of how international law exercises power and distributes resources around the world. Combined with efforts to decentralize the history of international law, Knop's private lens shows how individuals seeking to expand the capitalist frontier make international law, not only at the core, but also on the margins and in the interactions between the two.
Glacier thickness and volume estimation in the Upper Indus Basin using modeling and ground penetrating radar measurements
Authors: Romshoo Shakil Ahmad , Abdullah Tariq , Ameen Ummer , Bhat Mustafa Hameed
Published: January 2024

In the Himalaya, ice thickness data are limited, and field measurements are even scarcer. In this study, we employed the GlabTop model to estimate ice reserves in the Jhelum (1.9 ± 0.6 km3) and Drass (2.9 ± 0.9 km3) sub-basins of the Upper Indus Basin. Glacier ice thickness in the Jhelum ranged up to 187 ± 56 m with a mean of ~24 ± 7 m, while the Drass showed ice thickness up to 202 ± 60 m, with a mean of ~17 ± 5 m. Model results were validated using Ground Penetrating Radar measurements across four profiles in the ablation zone of the Kolahoi glacier in the Jhelum and nine profiles across the Machoi glacier in the Drass sub-basin. Despite underestimating ice-thickness by ~10%, the GlabTop model effectively captured glacier ice-thickness and spatial patterns in most of the profile locations where GPR measurements were taken. The validation showed high correlation coefficient of 0.98 and 0.87, low relative bias of ~ −13% and ~ −3% and a high Nash–Sutcliffe coefficient of 0.94 and 0.93 for the Kolahoi and Machoi glaciers, respectively, demonstrating the model's effectiveness. These ice-thickness estimates improve our understanding of glacio-hydrological, and glacial hazard processes over the Upper Indus Basin.
Research through co-design
Authors: Busciantella-Ricci Daniele , Scataglini Sofia
Published: January 2024

Research Through Design (RTD) needs to reconsider the meaning of “designing” in the research process of “through design.” We propose Research Through Co-design (RTC) as a new application of Control System Theory (CST) that includes a research problem assigned to a co-design process in RTD. It embeds the participatory paradigm through collaborative design practice and makes the research a collaborative process for learning from all the participants. To sustain the RTC theory, we present a cognitive model of RTC. It is a “model for” – rather than a “model of” – describing how the co-design, as a neural network process, works through its nodes’ collaboration to find co-designed solutions and the research answer. Diversity increases as non-experts and non-designers with different backgrounds participate. This is valuable for the RTC learning system. The discussions highlight the possibility of considering (i) the RTC model as useful for describing a robust RTD process through CST; (ii) RTC as a cognitive model for explaining the value of co-design in research processes; and (iii) RTC as a strategy for applying the participative paradigm in formal research. Finally, new insights and implications are highlighted, including using RTC as a predictive tool through artificial intelligence.
Are Metaphors Ethically Bad Epistemic Practice? Epistemic Injustice at the Intersections
Authors: Sibbald Kaitlin
Published: January 2024

The COVID-19 pandemic brought the debate about the ethics of metaphors to the fore. In this article, I draw on blending theory—a theory of cognition—and theories of epistemic injustice to explore both the epistemic and ethical implications of metaphors. Beginning with a discussion of the conceptual alterations that may result from the use of metaphors, I argue that the effects these alterations have on available hermeneutical resources have the potential to result in a type of hermeneutical injustice distinct from the “lacuna” described by Miranda Fricker (Fricker 2007). Following, I examine how metaphors may therefore be considered “ethically bad epistemic practice,” as described by Rebecca Mason, because of how they may contribute to perpetuating an inequitable epistemic status quo (Mason 2011). Yet these same features may be used to promote epistemic justice in the context of intersectional power relationships. Situating the effects of metaphors within an inequitable yet dynamic epistemic system, I argue that foregrounding intersectional power dynamics enables us to interrogate the ethics of metaphors with consideration of both the epistemic and material consequences that may occur. I conclude by providing guidance for how, given that metaphors do epistemic work, we may use them to do ethical epistemic work.
Vortices over bathymetry
Authors: LaCasce J.H. , Palóczy A. , Trodahl M.
Published: January 2024

There are numerous examples of long-lived, surface-intensified anticyclones over submarine depressions and troughs in the ocean. These often co-exist with a large-scale cyclonic circulation. The latter is predicted by existing barotropic theory but the anticyclone is not. We extend one such theory, which minimizes enstrophy while conserving energy, to two fluid layers. This yields a bottom-intensified flow with cyclonic circulation over a depression. The solution is steady, an enstrophy minimum and stable. When the Lagrange multiplier,

$\lambda$

, is near zero, the total potential vorticity (PV) becomes homogenized, in both layers. For positive

$\lambda$

, the surface PV is anticyclonic and strongest at intermediate energies. In quasi-geostrophic numerical simulations with a random initial perturbation PV, the bottom-intensified cyclonic flow always emerges. Vortices evolve independently in the layers and vortex mergers are asymmetric over the depression; cyclones are preferentially strained out at depth while only anticyclones merge at the surface. Both asymmetries are linked to the topographic flow. The deep cyclones feed the bottom-intensified cyclonic circulation while the asymmetry at the surface is only apparent after that circulation has spun up. The result of the surface merger asymmetry is often a lone anticyclone above the depression. This occurs primarily at intermediate energies, when the surface PV predicted by the theory is strongest. Similar results obtain in a full complexity ocean model but with a more pronounced asymmetry in surface vortex mergers and, with bottom friction, significant bottom flow beneath the central anticyclone.
Sex work and gendered tax imaginaries
Authors: Crowhurst Isabel
Published: January 2024

By exploring how the taxation of sex work is interpreted and explained, this article aims to expand theoretical and empirical understandings of tax imaginaries – the collectively formed meanings ascribed to taxes, taxpaying, and the purposes they serve – and how gender is mobilised in their construction. It argues that tax imaginaries created and circulated through online expert commentaries on the taxation of prostitution in Italy discredit sex workers through well-established stigmatising gendered tropes, trivialise the predicaments that they face as taxpayers, and ignore or dismiss systemic ambiguities and discriminations that disadvantage sex workers as citizens. Old prejudices against sex workers are thus reinforced and new ones constituted through these tax imaginaries, while the social inequality and marginalisation experienced by sex workers is obscured.
Study of iodine transport and thyroid hormone levels in the human placenta under different iodine nutritional status
Authors: Fu Min , Ren Zhiyuan , Gao Yuanpeng , Zhang Haixia , Guo Wenxing , Zhang Wanqi
Published: January 2024

Iodine and thyroid hormones (TH) transport in the placenta are essential for fetal growth and development, but there is little research focus on the human placenta. The research aimed to investigate iodine and TH transport mechanisms in the human placenta. The placenta was collected from sixty healthy pregnant women. Urinary iodine concentration (UIC), serum iodine concentration (SIC), placenta iodine storage (PIS) and the concentration of serum and placenta TH were examined. Five pregnant women were selected as insufficient intake (II), adequate intake (AI) and above requirements intake (ARI) groups. Localisation/expression of placental sodium/iodide symporter (NIS) and Pendrin were also studied. Results showed that PIS positively correlated with the UIC (R = 0·58, P < 0·001) and SIC (R = 0·55, P < 0·001), and PIS was higher in the ARI group than that in the AI group (P = 0·017). NIS in the ARI group was higher than that in the AI group on the maternal side of the placenta (P < 0·05). NIS in the II group was higher than that in the AI group on the fetal side (P < 0·05). In the II group, NIS on the fetal side was higher than on the maternal side (P < 0·05). Pendrin was higher in the II group than in the AI group on the maternal side (P < 0·05). Free triiodothyronine (r = 0·44, P = 0·0067) and thyroid-stimulating hormone (r = 0·75, P < 0·001) between maternal and fetal side is positively correlated. This study suggests that maternal iodine intake changes the expression of NIS and Pendrin, thereby affecting PIS. Serum TH levels were not correlated with placental TH levels.
Nutrients or processing? An analysis of food and drink items from the UK National Diet and Nutrition Survey based on nutrient content, the NOVA classification and front of package traffic light labelling
Authors: Dicken Samuel J. , Batterham Rachel L. , Brown Adrian
Published: January 2024

UK front of package labelling (FOPL) informs consumers on the nutrient content of food. However, FOPL does not consider food processing, and with the UK government being urged to act on ultra-processed food (UPF), whether UPF should be added to FOPL is unclear. This study compared food and drink in the UK National Diet and Nutrition Survey (NDNS) Intake24 database based on FOPL, nutrient content and NOVA classification, to understand whether UPF are covered by dietary recommendations for foods high in fat, salt and sugar. NDNS items were coded into minimally processed food (MPF), processed culinary ingredients, processed food and UPF according to the NOVA classification and FOPL traffic lights. UPF contained greater energy, fat, saturated fat (SF), total sugar (TS) and salt than MPF. UPF had a greater odds of containing red FOPL and an unhealthier overall FOPL score (OR:4·59 (95 % CI: 3·79, 5·57); OR:7·0 (95 % CI: 6·1, 8·2), respectively) and lower odds of containing green FOPL (OR:0·05 (95 % CI: 0·03, 0·10)), compared with MPFs. For items with no red FOPL, UPF still contained greater energy, fat, SF, TS and salt than MPF. However, several UPF have healthier FOPL scores. UPF had an unhealthier nutritional profile and FOPL score than MPF. For items with no red FOPL, UPF still had an unhealthier profile than MPF, with a higher energy density. Importantly, not all UPF were unhealthy according to FOPL. These results indicate partial overlap between FOPL, nutrient content and NOVA classification of UK food and drink products, with implications for UK food and drink labelling.
Fish oil supplement use modifies the relationship between dietary oily fish intake and plasma n-3 PUFA levels: an analysis of the UK Biobank
Authors: Aldoori Joanna , Zulyniak Michael A. , Toogood Giles J. , Hull Mark A.
Published: January 2024

Observational evidence linking dietary n-3 PUFA intake and health outcomes is limited by a lack of robust validation of dietary intake using blood n-3 PUFA levels and potential confounding by fish oil supplement (FOS) use. We investigated the relationship between oily fish intake, FOS use and plasma n-3 PUFA levels in 121 650 UK Biobank (UKBB) participants. Ordinal logistic regression models, adjusted for clinical and lifestyle factors, were used to quantify the contribution of dietary oily fish intake and FOS use to plasma n-3 PUFA levels (measured by NMR spectroscopy). Oily fish intake and FOS use were reported by 38 % and 31 % of participants, respectively. Increasing oily fish intake was associated with a higher likelihood of FOS use (P < 0·001). Oily fish intake ≥ twice a week was the strongest predictor of high total n-3 PUFA (OR 6·7 (95 % CI 6·3, 7·1)) and DHA levels (6·6 (6·3, 7·1). FOS use was an independent predictor of high plasma n-3 PUFA levels (2·0 (2·0, 2·1)) with a similar OR to that associated with eating oily fish < once a week (1·9 (1·8, 2·0)). FOS use was associated with plasma n-3 PUFA levels that were similar to individuals in the next highest oily fish intake category. In conclusion, FOS use is more common in frequent fish consumers and modifies the relationship between oily fish intake and plasma n-3 PUFA levels in UKBB participants. If unaccounted for, FOS use may confound the relationship between dietary n-3 PUFA intake, blood levels of n-3 PUFAs and health outcomes.
Ingestion of a variety of non-animal-derived dietary protein sources results in diverse postprandial plasma amino acid responses which differ between young and older adults
Authors: van der Heijden Ino , West Sam , Monteyne Alistair J. , Finnigan Tim J. A. , Abdelrahman Doaa R. , Murton Andrew J. , Stephens Francis B. , Wall Benjamin T.
Published: January 2024

Whole-body tissue protein turnover is regulated, in part, by the postprandial rise in plasma amino acid concentrations, although minimal data exist on the amino acid response following non-animal-derived protein consumption. We hypothesised that the ingestion of novel plant- and algae-derived dietary protein sources would elicit divergent plasma amino acid responses when compared with vegan- and animal-derived control proteins. Twelve healthy young (male (m)/female (f): 6/6; age: 22 ± 1 years) and 10 healthy older (m/f: 5/5; age: 69 ± 2 years) adults participated in a randomised, double-blind, cross-over trial. During each visit, volunteers consumed 30 g of protein from milk, mycoprotein, pea, lupin, spirulina or chlorella. Repeated arterialised venous blood samples were collected at baseline and over a 5-h postprandial period to assess circulating amino acid, glucose and insulin concentrations. Protein ingestion increased plasma total and essential amino acid concentrations (P < 0·001), to differing degrees between sources (P < 0·001), and the increase was further modulated by age (P < 0·001). Postprandial maximal plasma total and essential amino acid concentrations were highest for pea (2828 ± 106 and 1480 ± 51 µmol·l−1) and spirulina (2809 ± 99 and 1455 ± 49 µmol·l−1) and lowest for chlorella (2053 ± 83 and 983 ± 35 µmol·l−1) (P < 0·001), but were not affected by age (P > 0·05). Postprandial total and essential amino acid availabilities were highest for pea, spirulina and mycoprotein and lowest for chlorella (all P < 0·05), but no effect of age was observed (P > 0·05). The ingestion of a variety of novel non-animal-derived dietary protein sources elicits divergent plasma amino acid responses, which are further modulated by age.
PRISCE, IVBES (PLINY, EP. 6.15)
Authors: Panegyres Konstantine
Published: January 2024

In the famous exchange between Passennus Paulus and Javolenus Priscus at Plin. Ep. 6.15, it has not been previously recognized that Priscus’ reply is metrical and carries on the hexameter begun by Paulus. This opens up some interesting new possibilities for the interpretation of the letter.
Reptiles and their conservation in south-west Ukraine
Authors: Oskyrko Oleksandra , Lysenko Roman , Obikhod Daryna , Yakovliev Maksym , Haidash Oleksandr
Published: January 2024

Knowledge of the spatial distribution of reptiles is essential for decision-making in conservation under future climate change scenarios. We present a new compilation of reptile records for Odesa Oblast (i.e. province), south-west Ukraine. We compiled 662 records: 200 from our own research during 2012–2022, 362 from the published literature, 73 from public databases and 27 from museum collections. Fourteen native species of reptile (one species of Emydidae, four of Lacertidae, one of Anguidae, six of Colubridae and two of Viperidae) have been recorded in Odesa Oblast but the distribution of several are poorly known and/or records have rarely been published. We also report four introduced reptile species (one each of Emydidae, Gekkonidae, Lacertidae and Anguidae). We present the data in a grid of 462 10 × 10 km cells covering the oblast. In this compilation we did not record any new species, but our records include previously unreported localities for some species. Species richness was highest in the areas along the Black Sea, in protected areas. The main threats to the reptiles in Odesa Oblast are the alteration and degradation of habitats, military action, uncontrolled pressure from infrastructure projects and the presence of invasive species.
The complete mitochondrial genome of 3 species of allocreadiids (Digenea, Allocreadiidae): characterization and phylogenetic position within the order Plagiorchiida
Authors: Solórzano-García Brenda , Hernández-Mena David I. , Choudhury Anindo , Pérez-Ponce de León Gerardo
Published: January 2024

Trematodes of the family Allocreadiidae are primarily found in the intestines of freshwater fishes around the world. The family includes 15 genera and c. 130 species. The last 2 decades have witnessed an increase in the genetic library of its species. Molecular data have been crucial for species delimitation and species description within Allocreadiidae and for understanding their evolutionary and biogeographical history and classification. Here, the mitogenomes of 3 species of allocreadiids were obtained using high throughput sequencing methods. Mitogenomes were compared with other members of the order Plagiorchiida to determine their molecular composition, gene rearrangement and phylogenetic interrelationships. The complete circular mitogenomes of Allocreadium lobatum, Creptotrematina aguirrepequenoi and Wallinia mexicana were 14 424, 13 769 and 13 924 bp long respectively, comprising 12 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes and 2 non-coding regions. Gene arrangements were identical to other Xiphidiatan trematodes. Phylogenetic analyses using the mitogenomes revealed Allocreadiidae as a monophyletic group closely related to other members of the suborder Xiphidiata; A. lobatum was yielded as the sister taxon of C. aguirrepequenoi + W. mexicana. Our study increases the complete mitochondrial genome library of trematodes and strengthens our understanding of the phylogenetic relationships and classification of this parasite group.
Economic games for the study of peace
Authors: Böhm Robert , Columbus Simon
Published: January 2024

Economic games provide models of real-world contexts in which researchers can probe dispositional and structural determinants of intergroup relations. Most intergroup games focus on determinants of aggression between groups and constrain the possibilities for peace. However, paradigms such as the intergroup parochial and universal cooperation game allow for peaceful intergroup relations and can be adapted for the study of peace.
The evolution of (intergroup) peace hinges on how we define groups and peace
Authors: Pisor Anne C. , Smith Kristopher M. , Deminchuk Jeffrey P.
Published: January 2024

Glowacki defines peace as harmonious relationships between groups maintained without the threat of violence, where groups can be anything from families to nation states. However, defining such contentious concepts like “peace” and “groups” is a difficult task, and we discuss the implications of Glowacki's definitions for understanding intergroup relationships and their evolutionary history.
Disobedient Children, Hybrid Filiality: Negotiating Parent–Child Relations in Local Legal System in Republican China, 1911–1949
Authors: Han Shumeng , Ren Xiangyi
Published: January 2024

The principle of filial piety underpinned both parent–child relations and, more broadly, Qing legal and social order. Entering the turbulent years of the Qing–Republic transition, filial piety went through substantial changes. Drawn from the local legal archives in Jiangjin county, Sichuan, this research traces the transformation of filial piety in legal practice during the first half of the twentieth century. It argues that two overlapping processes—legal reforms and nation-state building—synergized to restructure the meaning of filial piety from a largely integrated principle in Qing, which bridged the gaps between filiality and loyalty to the emperor and between personalized morality and imperial state legitimacy, to divergent new interpretations of filial piety, including the individualist filial piety, nationalist filial piety, legal filial piety, and sentimental filial piety. Each new interpretation inherits only part of its original meaning and incorporates newly introduced legal knowledge of legal equality and property ownership. The article concludes that various, sometimes contradictory interpretations of filial piety indicate the Republican legal reforms as an in-between, dynamic spectrum of legal change with vigorous negotiations among different legal actors and knowledge regimes.
“Three Cheers for the United Aggregate Tribunal!”: Confronting Anti-Union Discourse, Then and Now
Authors: McAdams Ruth M.
Published: January 2024

In this piece, I discuss Charles Dickens's Hard Times (1855) in the context of my experience as one of the lead organizers of the successful campaign to unionize Skidmore College's non-tenure-track faculty. Dickens's novel outlines several claims that directly comprise modern anti-union discourse and that I saw straightforwardly rehearsed in 2022 as we sought to unionize. As an organizer and a Victorianist, I argue that we have ethical obligations in studying and teaching texts like Hard Times in light of the afterlives of their anti-union rhetoric. The Victorian industrial novel needs to be studied (and taught) from an explicitly pro-union perspective, by unionized workers. This paper contributes to that project.
Gaskell, Ghosts, and the Common Good
Authors: Betensky Carolyn , Schaffer Talia
Published: January 2024

How can tenure-track allies to adjunct workers contribute in our new era of anti-tenure attacks and surging labor activism? Two of the founders of Tenure for the Common Good find guidance in Elizabeth Gaskell's representations of class relations. Gaskell reveals the pervasive entrapment of exploitative systems and suggests ways that privileged participants can serve as intermediaries, amplifying the voices of those who need to be heard. Drawing on servant relations in Cranford and laborer relations in the North and South, we find warrant for a new visibility in the fight against adjunctification.
“What I Did at Vassar Stayed with Me”: Victorian Studies and Activism, a Case Study
Authors: Murdoch Lydia , Zlotnick Susan
Published: January 2024

Vassar College was one of the few North American undergraduate institutions to offer a concentration in Victorian studies. From 1970 until 2021, when the program transformed into Global Nineteenth-Century Studies, nearly ninety majors and minors passed through the program. Drawing on surveys and interviews with the program's graduates, the essay contends that Vassar's Victorian studies program engendered certain mental habits as well as specific approaches to activism, which the essay broadly defines to include activist scholarship and journalism, working for change within institutions, and reimagining family life and child-rearing. The Vassar alums who participated in the surveys and interviews made direct links between their activist commitments and an undergraduate education that emphasized primary-source research as well as multidisciplinarity.
Introduction
Authors: Ablow Rachel
Published: January 2024

Although not focused on the Victorian period, John Guillory's recent Professing Criticism: Essays on the Organization of Literary Study (2022) might seem to provide a bracing counter to the premise of this special issue. According to Guillory, framing our scholarly projects in political terms may ultimately be delusional, for whatever our aspirations or intentions, scholarship is rarely politically impactful. “Surely the political well-being of our society,” he writes, “is better served by producing one informed, insightful, and habitual reader than by the publication of any number of scholarly essays and books, however devastating these might be as criticisms of society” (78). For Guillory, claiming political significance for our scholarship amounts to an “overstatement of aim,” something he describes as “the principal form of professional deformation resulting from uncertainty about the social effects of literary study” (79).
Rumination and altered reactivity to sensory input as vulnerability factors for developing post-traumatic stress symptoms among adults with autistic traits
Authors: Dell’Osso Liliana , Amatori Giulia , Giovannoni Federico , Massimetti Enrico , Cremone Ivan Mirko , Carpita Barbara
Published: January 2024

Objective

Recent literature has suggested that individuals with autism spectrum disorder (ASD) or autistic traits (ATs) would be more likely to encounter traumatic events in their lifetime and to develop post-traumatic stress disorder (PTSD). However, the nature of this relationship has not yet been fully elucidated. The aims of this study were to evaluate the relationship between AT and PTSD and to investigate which specific autistic dimension was more associated with trauma and stress-related symptoms.

Methods

A total of 68 subjects with ASD and 64 healthy controls (HCs) were assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Trauma and Loss Spectrum (TALS) questionnaires. Statistical analyses included Mann–Whitney U test, chi-square test, calculation of Spearman’s coefficients, and logistic regression analysis.

Results

Patients with significant AT reported a 30% rate of PTSD and higher TALS total and domain scores than HCs, among whom no PTSD was found instead. Significant positive correlations were reported between AdAS Spectrum and TALS-SR scores in the whole sample. AdAS Spectrum total scores were statistically predictive of the presence of PTSD. High scores at AdAS Spectrum Hyper-Hyporeactivity to sensory input and Restrictive interest and rumination domains were identified as positive predictors of a probable PTSD.

Conclusion

Compared to HCs, subjects with significant AT are more likely to present symptoms of PTSD. In particular, AT related to ruminative thinking, narrow interests, and sensorial reactivity would seem to predict the presence of post-traumatic stress symptomatology.
Metamemory and executive function mediate the age-related decline in memory
Authors: Yeung Michael K.
Published: January 2024

Objective:

Although the effect of aging on episodic memory is relatively well studied, little is known about how aging influences metamemory. In addition, while executive function (EF) is known to mediate the age-related decline in episodic memory, the role of metamemory in aging-related memory differences beyond EF remains unknown. This study aimed to elucidate the effect of aging on metamemory and to clarify the role of metamemory in the age-related decline in memory.

Method:

One hundred and four adults aged 18–79 years (50 M, 54 F) performed several EF tasks, as well as a face-scene paired-associate learning task that required them to make judgments of learning, feeling-of-knowing judgments, and retrospective confidence judgments.

Results:

Aging was significantly associated with poor metamemory accuracy and increased confidence across metamemory judgment types, even after controlling for EF and memory performance. A parallel mediation analysis indicated that both confidence of learning and EF performance had significant partial mediation effects on the relationship between aging and memory, albeit in different ways. Specifically, poor EF explained the age-related decline in memory, whereas increased confidence of learning served to compensate for this memory decline.

Conclusions:

Aging is associated with general changes (i.e., poor inferences from cues) rather than specific changes (i.e., declined activation or utilization of certain cues) in metamemory monitoring. Also, changes in confidence of learning and in EF ability contribute to the preservation and decline of memory during aging, respectively. Therefore, boosting confidence during encoding and enhancing EF skills might be complementary memory intervention strategies for older adults.
Operational Risk Working Party - Validating Operational Risk Models
Authors: Kelliher Patrick O. J. , Acharyya Madhu , Couper Andrew J. , Maguire Edward N. V. , Pang Choong A. , Smerald Christopher M. , Sullivan Jennifer K. , Teggin Paul M.
Published: January 2024

Operational Risk is one of the most difficult risks to model. It is a large and diverse category covering anything from cyber losses to mis-selling fines; and from processing errors to HR issues. Data is usually lacking, particularly for low frequency, high impact losses, and consequently there can be a heavy reliance on expert judgement. This paper seeks to help actuaries and other risk professionals tasked with the challenge of validating models of operational risks. It covers the loss distribution and scenario-based approaches most commonly used to model operational risks, as well as Bayesian Networks. It aims to give a comprehensive yet practical guide to how one may validate each of these and provide assurance that the model is appropriate for a firm’s operational risk profile.
Measuring the intangible resources caregivers need to provide nurturing care during the complementary feeding period: a scoping review in low- and lower-middle-income countries
Authors: Martin Stephanie L , Zongrone Amanda A , Craig Hope C , Litvin Kate , Fort Peyton , Cooper Stephanie , Haller Mia , Dickin Katherine L
Published: January 2024

Objective:

Caregivers require tangible (e.g. food and financial) and intangible resources to provide care to ensure child health, nutrition and development. Intangible resources include beliefs and knowledge, education, self-efficacy, perceived physical health, mental health, healthy stress levels, social support, empowerment, equitable gender attitudes, safety and security and time sufficiency. These intangible caregiver resources are included as intermediate outcomes in nutrition conceptual frameworks yet are rarely measured as part of maternal and child nutrition research or evaluations. To facilitate their measurement, this scoping review focused on understudied caregiver resources that have been measured during the complementary feeding period in low- and lower-middle-income countries.

Design:

We screened 9,232 abstracts, reviewed 277 full-text articles and included 163 articles that measured caregiver resources related to complementary feeding or the nutritional status of children 6 months to 2 years of age.

Results:

We identified measures of each caregiver resource, though the number of measures and quality of descriptions varied widely. Most articles (77 %) measured only one caregiver resource, mental health (n 83) and social support (n 54) most frequently. Psychometric properties were often reported for mental health measures, but less commonly for other constructs. Few studies reported adapting measures for specific contexts. Existing measures for mental health, equitable gender attitudes, safety and security and time sufficiency were commonly used; other constructs lacked standardised measures.

Conclusions:

Measurement of caregiver resources during the complementary feeding period is limited. Measuring caregiver resources is essential for prioritising caregivers and understanding how resources influence child care, feeding and nutrition.
Boosted Poisson regression trees: a guide to the BT package in R
Authors: Willame Gireg , Trufin Julien , Denuit Michel
Published: January 2024

Thanks to its outstanding performances, boosting has rapidly gained wide acceptance among actuaries. Wüthrich and Buser (Data Analytics for Non-Life Insurance Pricing. Lecture notes available at SSRN. http://dx.doi.org/10.2139/ssrn.2870308, 2019) established that boosting can be conducted directly on the response under Poisson deviance loss function and log-link, by adapting the weights at each step. This is particularly useful to analyze low counts (typically, numbers of reported claims at policy level in personal lines). Huyghe et al. (Boosting cost-complexity pruned trees on Tweedie responses: The ABT machine for insurance ratemaking. Scandinavian Actuarial Journal. https://doi.org/10.1080/03461238.2023.2258135, 2022) adopted this approach to propose a new boosting machine with cost-complexity pruned trees. In this approach, trees included in the score progressively reduce to the root-node one, in an adaptive way. This paper reviews these results and presents the new BT package in R contributed by Willame (Boosting Trees Algorithm. https://cran.r-project.org/package=BT; https://github.com/GiregWillame/BT, 2022), which is designed to implement this approach for insurance studies. A numerical illustration demonstrates the relevance of the new tool for insurance pricing.
Recusal as Remedy: Disincentivizing Donors
Authors: Edelstein Benjamin D. , Benesh Sara C.
Published: January 2024

As judicial elections become increasingly expensive, recusal has emerged as a way to address concerns about the impartiality of judges who receive contributions from lawyers or potential litigants. While it is unclear if strict recusal rules are the best remedy for conflicts of interest created by contributions, they may disincentivize potential donors from investing in judicial campaigns by negating their potential goal of influencing decisions. We consider whether donor behavior in judicial campaigns – especially for those donors most likely to be interested in specifically currying favor with judges – responds to differences in recusal standards. Using data from 219 state supreme court races in 22 states from 2010 to 2020, we find that states with stricter recusal rules attract fewer campaign donations to judicial races, and states with more lax rules attract more overall and, most especially, for attorney donors.
Sport- und Bewegungstherapie in der Behandlung psychischer Störungen bei Kindern und Jugendlichen
Authors: Kauczor-Rieck Katja , Allroggen Marc , Gradl-Dietsch Gertraud
Published: January 2024

Zusammenfassung: Psychische Störungen gehören in Deutschland und weltweit zu den häufigsten chronischen Erkrankungen im Kindes- und Jugendalter. Die gesundheitlichen Vorteile eines sportlich aktiven Lebenswandels in der Kindheit und Jugend sind gut belegt. Es besteht zudem ein Zusammenhang zwischen regelmäßiger körperlicher Aktivität und psychischer Gesundheit sowie emotionalem Wohlbefinden. Auch scheint Sport das Risiko für die Entwicklung psychischer Erkrankungen zu reduzieren. Bewegungs- und sporttherapeutische Angebote nehmen daher in der klinischen Kinder- und Jugendpsychiatrie einen hohen Stellenwert ein. Die beschriebenen Effekte sollten in randomisiert-kontrollierte Studien mit ausreichend hohen Fallzahlen noch besser evaluiert werden.
Genotype imputation methods for whole and complex genomic regions utilizing deep learning technology
Authors: Naito Tatsuhiko , Okada Yukinori
Published: January 2024

The imputation of unmeasured genotypes is essential in human genetic research, particularly in enhancing the power of genome-wide association studies and conducting subsequent fine-mapping. Recently, several deep learning-based genotype imputation methods for genome-wide variants with the capability of learning complex linkage disequilibrium patterns have been developed. Additionally, deep learning-based imputation has been applied to a distinct genomic region known as the major histocompatibility complex, referred to as HLA imputation. Despite their various advantages, the current deep learning-based genotype imputation methods do have certain limitations and have not yet become standard. These limitations include the modest accuracy improvement over statistical and conventional machine learning-based methods. However, their benefits include other aspects, such as their “reference-free” nature, which ensures complete privacy protection, and their higher computational efficiency. Furthermore, the continuing evolution of deep learning technologies is expected to contribute to further improvements in prediction accuracy and usability in the future.
Are probiotics effective in reducing the metabolic side effects of psychiatric medication? A scoping review of evidence from clinical studies
Authors: Mötteli Sonja , Vetter Stefan , Colla Michael , Hotzy Florian
Published: January 2024

The psychopharmacological treatment of patients with schizophrenia or depression is often accompanied by serious side effects. In particular, the clinical findings of weight gain are worrying, as this side effect can lead to various medical sequelae in the future. However, the treatment of metabolic changes in psychiatric patients is often neglected or unsuccessful. An improved knowledge of possible therapeutic approaches is needed. The aim of this study was to provide an overview of the utilisation and effectiveness of probiotics in reducing weight gain in patients with severe mental illness. A scoping review of studies published until 15 June 2022 was conducted to identify studies using probiotics in people with schizophrenia or depression. We systematically searched the databases EMBASE, PubMed (MEDLINE), Web of Science and SCOPUS with a predefined search string. In addition, reference lists of relevant publications were examined for additional studies. The studies were assessed by two reviewers. The primary outcomes were weight-related measurements. The secondary outcomes were metabolic blood parameters and gut microbiota. Four studies ultimately met the inclusion criteria. Two studies in which probiotics were administered did not find significant effects on pharmacologically induced weight gain. The other two studies examined the effects of synbiotics (a combination of probiotics and prebiotics). Interestingly, less weight gain was observed in individuals with this combined intervention. Adjustments in diet can be helpful and are generally well-accepted interventions in the fight against pharmacologically induced weight gain. The clinical use of probiotics and prebiotics (or synbiotics) as dietary interventions may represent a promising additional strategy in this regard. However, the few studies available showed no clear conclusions.
USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons
Authors: Okarmus Justyna , Agergaard Jette Bach , Stummann Tina C. , Haukedal Henriette , Ambjørn Malene , Freude Kristine K. , Fog Karina , Meyer Morten
Published: January 2024

Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by PARK2) and the ubiquitin-specific protease 30 (USP30) have both been reported to regulate the ubiquitination of outer mitochondrial proteins and thereby mitophagy. Loss of E3 ligase activity is thought to be pathogenic in both sporadic and inherited Parkinson’s disease (PD), with loss-of-function mutations in PARK2 being the most frequent cause of autosomal recessive PD. The aim of the present study was to evaluate whether mitophagy induced by USP30 inhibition provides a functional rescue in isogenic human induced pluripotent stem cell-derived dopaminergic neurons with and without PARK2 knockout (KO). Our data show that healthy neurons responded to CCCP-induced mitochondrial damage by clearing the impaired mitochondria and that this process was accelerated by USP30 inhibition. Parkin-deficient neurons showed an impaired mitophagic response to the CCCP challenge, although mitochondrial ubiquitination was enhanced. USP30 inhibition promoted mitophagy in PARK2 KO neurons, independently of whether left in basal conditions or treated with CCCP. In PARK2 KO, as in control neurons, USP30 inhibition balanced oxidative stress levels by reducing excessive production of reactive oxygen species. Interestingly, non-dopaminergic neurons were the main driver of the beneficial effects of USP30 inhibition. Our findings demonstrate that USP30 inhibition is a promising approach to boost mitophagy and improve cellular health, also in parkin-deficient cells, and support the potential relevance of USP30 inhibitors as a novel therapeutic approach in diseases with a need to combat neuronal stress mediated by impaired mitochondria.
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function
Authors: Zhu Yue , Wang Qinqin , Xie Xinyu , Ma Cuihong , Qiao Yuemei , Zhang Yu , Wu Yanjun , Gao Yuan , Jiang Jing , Liu Xin , Chen Jianfeng , Li Chen , Ge Gaoxiang
Published: January 2024

Hepatocarcinogenesis is a multi-step process. However, the regulators of hepatocellular carcinoma (HCC) initiation are understudied. Adult liver-specific gene expression was globally downregulated in HCC. We hypothesize that adult liver-specific genes, especially adult liver-enriched transcription factors may exert tumor-suppressive functions in HCC. In this study, we identify ZBTB7B, an adult liver-enriched transcription factor as a permissive regulator of HCC initiation. ZBTB7B is highly expressed in hepatocytes in adult livers, compared to fetal livers. To evaluate the functions of ZBTB7B in hepatocarcinogenesis, we performed hepatocyte-specific ZBTB7B knockout in hydrodynamic oncogene transfer-induced mouse liver cancer models. Hepatocyte-specific knockout of ZBTB7B promotes activated Akt and N-Ras-induced HCC development. Moreover, ZBTB7B deficiency sensitizes hepatocytes to a single oncogene Akt-induced oncogenic transformation and HCC initiation, which is otherwise incompetent in inducing HCC. ZBTB7B deficiency accelerates HCC initiation by down-regulating adult liver-specific gene expression and priming livers to a fetal-like state. The molecular mechanism underlying ZBTB7B functions in hepatocytes was investigated by integrated transcriptomic, phosphoproteomic, and chromatin immunoprecipitation-sequencing analyses. Integrative multi-omics analyses identify c-Jun as the core signaling node in ZBTB7B-deficient liver cancer initiation. c-Jun is a direct target of ZBTB7B essential to accelerated liver cancer initiation in ZBTB7B-deficient livers. Knockdown of c-Jun expression or dominant negative c-Jun expression delays HCC development in ZBTB7B-deficient livers. In addition, ZBTB7B competes with c-Jun for chromatin binding. Ectopic ZBTB7B expression attenuates the tumor-promoting functions of c-Jun. Expression of ZBTB7B signature, composed of 140 genes co-regulated by ZBTB7B and c-Jun, is significantly downregulated in early-stage HCCs compared to adjacent normal tissues, correlates to liver-specific gene expression, and is associated with good prognosis in human HCC. Thus, ZBTB7B functions as a permissive regulator of HCC initiation by directly regulating c-Jun expression and function.