bluuebunny/crossref_metadata_2025 huggingface dataset:
Applied Sciences: “Coastal Deposits: Environmental Implications, Mathematical Modeling and Technological Development”
Authors: Pérez-Arlucea Marta , González-Villanueva Rita
Published: December 2020

A large percentage of the world’s population lives along the coastal zones, with more than half of the world’s population living in coastal areas [...]
Triaxial Compression Performance Research of Steel Slag Concrete on the Unified Strength Theory
Authors: Deng Zhiheng , Zhou Jingkai , Chen Beiquan , Wen Xiaoyan , Liu Bing
Published: December 2020

To better explore the mechanical properties of steel slag concrete (SSC) under triaxial compression, true triaxial tests were performed on SSC with three replacement ratios (30%, 70%, 100%) by a servo-controlled setup (TAWZ-5000/3000). Through the test, failure modes, peak stress, and corresponding strain of SSC are obtained. Results show that the failure modes of SSC are plate-splitting and slant-shear. Compared with the corresponding uniaxial strength, the triaxial compressive strength of SSC is significantly improved and is influenced by the stress ratio and the replacement ratio. Finally, based on unified strength theory, the strength failure criterion formula of SSC with different replacement rates under triaxial compression is given.
A Fast Method of Visually Lossless Compression of Dental Images
Authors: Krivenko Sergey , Lukin Vladimir , Krylova Olha , Kryvenko Liudmyla , Egiazarian Karen
Published: December 2020

A noniterative approach to the problem of visually lossless compression of dental images is proposed for an image coder based on the discrete cosine transform (DCT) and partition scheme optimization. This approach considers the following peculiarities of the problem. It is necessary to carry out lossy compression of dental images to achieve large compression ratios (CRs). Since dental images are viewed and analyzed by specialists, it is important to preserve useful diagnostic information preventing appearance of any visible artifacts due to lossy compression. At last, dental images may contain noise having complex statistical and spectral properties. In this paper, we have analyzed and utilized dependences of three quality metrics (Peak signal-to-noise ratio, PSNR; eak Signal-to-Noise Ratio using Human Visual System and Masking (PSNR-HVS-M); and feature similarity, FSIM) on the quantization step (QS), which controls a compression ratio for the so-called advanced DCT coder (ADCTC). The threshold values of distortion visibility for these metrics have been considered. Finally, the recent results on detectable changes in noise intensity have been incorporated in the QS setting. A visual comparison of original and compressed images allows to conclude that the introduced distortions are practically undetectable for the proposed approach; meanwhile, the provided CR lies within the interval.
Interfacial Shearing Behavior along Xanthan Gum Biopolymer-Treated Sand and Solid Interfaces and Its Meaning in Geotechnical Engineering Aspects
Authors: Lee Minhyeong , Im Jooyoung , Cho Gye-Chun , Ryu Hee Hwan , Chang Ilhan
Published: December 2020

Recently, environment-friendly microbial biopolymer has been widely applied as a new construction material in geotechnical engineering practices including soil stabilization, slope protection, and ground injection. Biopolymer is known to exhibit substantial improvements in geotechnical properties, such as shear strength enhancement and hydraulic conductivity reduction, through the formation of direct ionic bonds with soil particles, especially clay particles. Moreover, the rheological characteristics (e.g., pseudoplasticity, shear-rate dependent thixotropy) of biopolymers render distinctive behaviors such as shear thinning and lubrication effect under a high strain condition, while recovering their viscosities and shear stiffnesses when they are at rest. To ensure the practical applicability of biopolymer-based soil treatment, it is important to understand the interfacial interaction (i.e., friction) between biopolymer-treated soil and adjoining structural members which can be constructed in a biopolymer-treated ground. Thus, in this paper, interfacial shearing behavior of biopolymer-treated soil along solid surfaces as well as internal shearing on biopolymer-soil matrix were explored via direct and interface shear test. Experimental results show a predominant effect of the soil moisture content on the interfacial shear behavior of biopolymer-treated soil which attributes to the rheology transition of biopolymer hydrogels. At low moisture content, condensed biopolymer biofilm mobilizes strong intergranular bonding, where the interfacial shear mainly depends on the physical condition along the surface including the asperity angle. In contrast, the biopolymer induced intergranular bonding weakens as moisture content increases, where most interfacial failures occur in biopolymer-treated soil itself, regardless of the interface condition. In short, this study provides an overall trend of the interfacial friction angle and adhesion variations of xanthan gum biopolymer-treated sand which could be referred when considering a subsequent structural member construction after a biopolymer-based ground improvement practice in field.
Antiviral Role of Phenolic Compounds against Dengue Virus: A Review
Authors: Loaiza-Cano Vanessa , Monsalve-Escudero Laura Milena , Filho Carlos da Silva Maia Bezerra , Martinez-Gutierrez Marlen , Sousa Damião Pergentino de
Published: December 2020

Phenolic compounds have been related to multiple biological activities, and the antiviral effect of these compounds has been demonstrated in several viral models of public health concern. In this review, we show the antiviral role of phenolic compounds against dengue virus (DENV), the most widespread arbovirus globally that, after its re-emergence, has caused multiple epidemic outbreaks, especially in the last two years. Twenty phenolic compounds with anti-DENV activity are discussed, including the multiple mechanisms of action, such as those directed against viral particles or viral proteins, host proteins or pathways related to the productive replication viral cycle and the spread of the infection.
Bacterial-Derived Plant Protection Metabolite 2,4-Diacetylphloroglucinol: Effects on Bacterial Cells at Inhibitory and Subinhibitory Concentrations
Authors: Julian William T. , Vasilchenko Anastasia V. , Shpindyuk Daniil D. , Poshvina Darya V. , Vasilchenko Alexey S.
Published: December 2020

2,4-Diacetylphloroglucinol (2,4-DAPG) is a well-known bacterial secondary metabolite, however, its mechanism of inhibitory and subinhibitory action on bacterial cells is still poorly understood. The mechanism of 2,4-DAPG action on model bacterial strains was investigated using fluorescent spectroscopy and the action of the antibiotic was found to involve a rapid increase in membrane permeability that was accompanied by a reduction in its viability in nutrient-poor medium. At the same time, antibacterial action in nutrient-rich medium developed for several hours. Atomic force microscopy demonstrated time-dependent disturbances in the outer membrane of Escherichia coli when exposed to 2,4-DAPG, while Staphylococcusaureus cells have been visualized with signs of intracellular leakage. In addition, 2,4-DAPG inhibited the metabolic activity of S. aureus and E. coli bacterial cells in mature biofilms. Observed differences in the antibiofilm activity were dependent upon antibiotic concentration. The intracellular targets of the action of 2,4-DAPG were assessed using bacterial biosensors with inducible bioluminescence corresponding to DNA and protein damage. It was unable to register any positive response from either sensor. As a result, the bactericidal action of 2,4-DAPG is believed to be associated with the destruction of the bacterial barrier structures. The subinhibitory effect of 2,4-diacetylphloroglucinol was tested on quorum-sensing mediated processes in Pectobacterium carotovorum. Subinhibitory concentrations of 2,4-DAPG were found to lower the biosynthesis of acyl-homoserine lactones in P. carotovorum in a dose-dependent manner. Further investigation elucidated that 2,4-DAPG inhibits the metabolic activity of bacteria without affecting their viability.
DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D
Authors: Pérez Raúl , Fernandez-Morera Juan , Romano-Garcia Judit , Menendez-Torre Edelmiro , Delgado-Alvarez Elias , Fraga Mario , Fernandez Agustin
Published: December 2020

Type 1 diabetes (T1D) is an autoimmune disease that leads to insulin deficiency and hyperglycemia. Little is known about how this metabolic dysfunction, which substantially alters the internal environment, forces cells to adapt through epigenetic mechanisms. Consequently, the purpose of this work was to study what changes occur in the epigenome of T1D patients after the onset of disease and in the context of poor metabolic control. We performed a genome-wide analysis of DNA methylation patterns in blood samples from 18 T1D patients with varying levels of metabolic control. We identified T1D-associated DNA methylation differences on more than 100 genes when compared with healthy controls. Interestingly, only T1D patients displaying poor glycemic control showed epigenetic age acceleration compared to healthy controls. The epigenetic alterations identified in this work make a valuable contribution to improving our understanding of T1D and to ensuring the appropriate management of the disease in relation to maintaining healthy aging.
Differential Expression of Inflammatory Markers in Hypoglycemia Unawareness Associated with Type 1 Diabetes: A Case Report
Authors: Al Zoubi Yousef , Mussa Bashair M. , Srivastava Ankita , Mohammed Abdul Khader , Abdelgadir Elamin , Bashier Alaaeldin , Awadi Fatheya Al , Abusnana Salah
Published: December 2020

The recurrence of hypoglycemic episodes leads to attenuation of the normal counter-regulatory mechanisms that are controlled by the hypothalamus, which results in hypoglycemia unawareness (HU). In this case report, we described for the first time the differential expression of TNF-α, IL-1β, IL-6, and IFN-γ in a blood sample that was taken from a 27-year-old patient with type 1 diabetes mellitus (T1DM) who was diagnosed with HU. The anti-diabetic regimen is currently based on insulin injection, but the patient is planning to start the use of an insulin pump to have better control of glucose levels. Our results showed a trend toward an increase in the expression of IL-1β, IL-6, and IFN-γ in T1DM patient with HU. However, the mRNA level of TNF-α showed a significant decrease. These observations suggest that systemic inflammation could be an underlying cause of HU.
Nonlinear Static Seismic Response of a Building Equipped with Hybrid Cross-Laminated Timber Floor Diaphragms and Concentric X-Braced Steel Frames
Authors: Roncari Andrea , Gobbi Filippo , Loss Cristiano
Published: December 2020

Simplified seismic design procedures mostly recommend the adoption of rigid floor diaphragms when forming a building’s lateral force-resisting structural system. While rigid behavior is compatible with many reinforced concrete or composite steel-concrete floor systems, the intrinsic stiffness properties of wood and ductile timber connections of timber floor slabs typically make reaching a such comparable in-plane response difficult. Codes or standards in North America widely cover wood-frame construction, with provisions given for both rigid and flexible floor diaphragms designs. Instead, research is ongoing for emerging cross-laminated-timber (CLT) and hybrid CLT-based technologies, with seismic design codification still currently limited. This paper deals with a steel-CLT-based hybrid structure built by assembling braced steel frames with CLT-steel composite floors. Preliminary investigation on the performance of a 3-story building under seismic loads is presented, with particular attention to the influence of in-plane timber diaphragms flexibility on the force distribution and lateral deformation at each story. The building complies with the Italian Building Code damage limit state and ultimate limit state design requirements by considering a moderate seismic hazard scenario. Nonlinear static analyses are performed adopting a finite-element model calibrated based on experimental data. The CLT-steel composite floor in-plane deformability shows mitigated effects on the load distribution into the bracing systems compared to the ideal rigid behavior. On the other hand, the lateral deformation always rises at least 17% and 21% on average, independently of the story and load distribution along the building’s height.
(Endo)Cannabinoids and Gynaecological Cancers
Authors: Taylor Anthony H. , Tortolani Daniel , Ayakannu Thangesweran , Konje Justin C. , Maccarrone Mauro
Published: December 2020

Gynaecological cancers can be primary neoplasms, originating either from the reproductive tract or the products of conception, or secondary neoplasms, representative of metastatic disease. For some of these cancers, the exact causes are unknown; however, it is recognised that the precise aetiopathogeneses for most are multifactorial and include exogenous (such as diet) and endogenous factors (such as genetic predisposition), which mutually interact in a complex manner. One factor that has been recognised to be involved in the pathogenesis and progression of gynaecological cancers is the endocannabinoid system (ECS). The ECS consists of endocannabinoids (bioactive lipids), their receptors, and metabolic enzymes responsible for their synthesis and degradation. In this review, the impact of plant-derived (Cannabis species) cannabinoids and endocannabinoids on gynaecological cancers will be discussed within the context of the complexity of the proteins that bind, transport, and metabolise these compounds in reproductive and other tissues. In particular, the potential of endocannabinoids, their receptors, and metabolic enzymes as biomarkers of specific cancers, such as those of the endometrium, will be addressed. Additionally, the therapeutic potential of targeting selected elements of the ECS as new action points for the development of innovative drugs will be presented.
The Influence of Chimeric Antigen Receptor Structural Domains on Clinical Outcomes and Associated Toxicities
Authors: Davey Ashleigh S. , Call Matthew E. , Call Melissa J.
Published: December 2020

Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of B cell malignancies, improving patient survival and long-term remission. Nonetheless, over 50% of patients experience severe treatment-related toxicities including cytokine release syndrome (CRS) and neurotoxicity. Differences in severity of toxic side-effects among anti-CD19 CARs suggest that the choice of costimulatory domain makes a significant contribution to toxicity, but comparisons are complicated by additional differences in the hinge and transmembrane (TM) domains of the most commonly used CARs in the clinic, segments that have long been considered to perform purely structural roles. In this perspective, we examine clinical and preclinical data for anti-CD19 CARs with identical antigen-binding (FMC63) and signalling (CD3ζ) domains to unravel the contributions of different hinge-TM and costimulatory domains. Analysis of clinical trials highlights an association of the CD28 hinge-TM with higher incidence of CRS and neurotoxicity than the corresponding sequences from CD8, regardless of whether the CD28 or the 4-1BB costimulatory domain is used. The few preclinical studies that have systematically varied these domains similarly support a strong and independent role for the CD28 hinge-TM sequence in high cytokine production. These observations highlight the value that a comprehensive and systematic interrogation of each of these structural domains could provide toward developing fundamental principles for rational design of safer CAR-T cell therapies.
Bile-Based Cell-Free DNA Analysis Is a Reliable Diagnostic Tool in Pancreatobiliary Cancer
Authors: Driescher Caroline , Fuchs Katharina , Haeberle Lena , Goering Wolfgang , Frohn Lisa , Opitz Friederike V. , Haeussinger Dieter , Knoefel Wolfram Trudo , Keitel Verena , Esposito Irene
Published: December 2020

Currently available serum biomarkers for pancreatobiliary cancers lack sensitivity and specificity and ultimate diagnosis still requires invasive procedures for histological confirmation. The detection of tumor-specific genetic aberrations with utilization of cell free DNA (cfDNA) is a less invasive approach than traditional tissue biopsies; however, it has not been implemented into clinical routine. In this study, we investigated bile as a liquid biopsy source in pancreatobiliary cancers and compared its potential as cell-free DNA source to plasma. Blood (n = 37) and bile (n = 21) samples were collected from patients affected by pancreatic ductal adenocarcinoma (PDAC) and extrahepatic cholangiocarcinoma (CCA) or with non-malignant biliary obstructions (blood n = 16; bile n = 21). Panel-based next generation sequencing (NGS) and digital droplet PCR (ddPCR) were applied for tumor mutation profiling. NGS results from matched tumor tissues (n = 29) served as comparison. Sequencing of cfDNA from bile resulted in detection of 96.2% of the pathogenic tumor mutations found in matched tissue samples. On the other hand, only 31.6% of pathogenic tumor mutations found in tissue could be detected in plasma. In a direct comparison, only half of the mutations detected in bile cfDNA were concordantly detected in plasma from the same patients. Panel NGS and ddPCR displayed comparable sensitivity. In conclusion, bile is a suitable source of cfDNA for the diagnosis of pancreatobiliary cancer and performs more reliably than plasma. Although primary diagnosis still requires histologic confirmation, bile-derived cfDNA could offer an alternative if tissue sampling is not feasible and might allow less invasive disease monitoring.
TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma
Authors: Campolo Michela , Lanza Marika , Casili Giovanna , Paterniti Irene , Filippone Alessia , Caffo Maria , Cardali Salvatore M. , Puliafito Ivana , Colarossi Cristina , Raciti Gabriele , Cuzzocrea Salvatore , Esposito Emanuela
Published: December 2020

Glioblastoma (GBM) is a brain tumor characterized by poor therapeutic response and overall survival. Despite relevant progress in conventional treatments represented by the clinical use of temozolomide (TMZ), a combination of approaches might be a possible future direction for treating GBM. Transforming growth factor-beta-activated kinase-1 (TAK1) is an essential component in genotoxic stresses-induced NF-κB-activation and mitogen-activated protein kinase (MAPK)-pathways; however, the role of TAK1 in GBM-chemoresistance remains unknown. This study aimed to verify, in GBM human cell lines, in an in vivo U87-xenograft model and in TMZ-treated-patients, the effect of TAK1 inhibition on the sensitivity of GBM cells to chemotherapy. In vitro model, using GBM cell lines, showed that 5Z-7-oxozeaenol augmented the cytotoxic effects of TMZ, blocking TMZ-induced NF-κB-activation, reducing DNA-damage and enhancing TMZ-induced apoptosis in GMB cell lines. We showed a reduction in tumor burden as well as tumor volume in the xenograft model following the treatment with 5Z-7-oxozaenol associated with TMZ. Our results showed a significant up-regulation in TAK1, p-p38, p-JNK and NF-κB in glioblastoma TMZ-treated-patients and denoted the role of 5Z-7-oxozeaenol in increasing the sensitivity of GBM cells to chemotherapy, proving to be an effective coadjuvant to current GBM chemotherapeutic regimens, suggesting a new option for therapeutic treatment of GBM.
The Nuclear Pore Complex and mRNA Export in Cancer
Authors: Borden Katherine L. B.
Published: December 2020

Export of mRNAs from the nucleus to the cytoplasm is a key regulatory step in the expression of proteins. mRNAs are transported through the nuclear pore complex (NPC). Export of mRNAs responds to a variety of cellular stimuli and stresses. Revelations of the specific effects elicited by NPC components and associated co-factors provides a molecular basis for the export of selected RNAs, independent of bulk mRNA export. Aberrant RNA export has been observed in primary human cancer specimens. These cargo RNAs encode factors involved in nearly all facets of malignancy. Indeed, the NPC components involved in RNA export as well as the RNA export machinery can be found to be dysregulated, mutated, or impacted by chromosomal translocations in cancer. The basic mechanisms associated with RNA export with relation to export machinery and relevant NPC components are described. Therapeutic strategies targeting this machinery in clinical trials is also discussed. These findings firmly position RNA export as a targetable feature of cancer along with transcription and translation.
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment
Authors: Baj Jacek , Forma Alicja , Sitarz Monika , Portincasa Piero , Garruti Gabriella , Krasowska Danuta , Maciejewski Ryszard
Published: December 2020

Gastric cancer constitutes one of the most prevalent malignancies in both sexes; it is currently the fourth major cause of cancer-related deaths worldwide. The pathogenesis of gastric cancer is associated with the interaction between genetic and environmental factors, among which infection by Helicobacter pylori (H. pylori) is of major importance. The invasion, survival, colonization, and stimulation of further inflammation within the gastric mucosa are possible due to several evasive mechanisms induced by the virulence factors that are expressed by the bacterium. The knowledge concerning the mechanisms of H. pylori pathogenicity is crucial to ameliorate eradication strategies preventing the possible induction of carcinogenesis. This review highlights the current state of knowledge and the most recent findings regarding H. pylori virulence factors and their relationship with gastric premalignant lesions and further carcinogenesis.
Kelvin/Rossby Wave Partition of Madden-Julian Oscillation Circulations
Authors: Haertel Patrick
Published: December 2020

The Madden Julian Oscillation (MJO) is a large-scale convective and circulation system that propagates slowly eastward over the equatorial Indian and Western Pacific Oceans. Multiple, conflicting theories describe its growth and propagation, most involving equatorial Kelvin and/or Rossby waves. This study partitions MJO circulations into Kelvin and Rossby wave components for three sets of data: (1) a modeled linear response to an MJO-like heating; (2) a composite MJO based on atmospheric sounding data; and (3) a composite MJO based on data from a Lagrangian atmospheric model. The first dataset has a simple dynamical interpretation, the second provides a realistic view of MJO circulations, and the third occurs in a laboratory supporting controlled experiments. In all three of the datasets, the propagation of Kelvin waves is similar, suggesting that the dynamics of Kelvin wave circulations in the MJO can be captured by a system of equations linearized about a basic state of rest. In contrast, the Rossby wave component of the observed MJO’s circulation differs substantially from that in our linear model, with Rossby gyres moving eastward along with the heating and migrating poleward relative to their linear counterparts. These results support the use of a system of equations linearized about a basic state of rest for the Kelvin wave component of MJO circulation, but they question its use for the Rossby wave component.
Preparation and Characterization of Some Sol-Gel Modified Silica Coatings Deposited on Polyvinyl Chloride (PVC) Substrates
Authors: Purcar Violeta , Rădițoiu Valentin , Rădițoiu Alina , Manea Raluca , Raduly Florentina Monica , Ispas Georgiana Cornelia , Frone Adriana Nicoleta , Nicolae Cristian Andi , Gabor Raluca Augusta , Anastasescu Mihai , Stroescu Hermine , Căprărescu Simona
Published: December 2020

Transparent and antireflective coatings were prepared by deposition of modified silica materials onto polyvinyl chloride (PVC) substrates. These materials were obtained by the sol-gel route in acidic medium, at room temperature (25 °C), using different alkoxysilanes with various functional groups (methyl, vinyl, octyl or hexadecyl). Physicochemical and microstructural properties of resulted silica materials and of thin coatings were investigated through Fourier Transforms Infrared Spectroscopy (FTIR), UV-Vis spectroscopy, Thermal Gravimetric Analysis (TGA), Dynamic Mechanical Analysis (DMA), Atomic Force Microscopy (AFM) and ellipsometric measurements. Wetting behaviors of the silica coatings were evaluated by measurement of static contact angle against water. FTIR spectra of materials confirmed the high degree of cross-linking that result from the formation of the inorganic backbone through the hydrolysis and polycondensation reactions together with the formation of the organic network. These sol-gel silica coatings showed a reduction in the reflectance (10%) compared with uncoated PVC substrate. AFM reveals that the films are uniform, and adherent to the substrate, but their morphology is strongly influenced by the chemical composition of the coating matrices. These silica coatings can be useful for potential electronic and optical devices.
Investigation of Polystyrene-Based Microspheres from Different Copolymers and Their Structural Color Coatings on Wood Surface
Authors: Liu Yi , Hu Jing
Published: December 2020

Six kinds of polystyrene (PSt)-based colloidal microspheres were synthesized by adding acrylic acid (AA), methyl methacrylate (MMA), and butyl acrylate (BA) as comonomers in styrene emulsion polymerization. The structurally colored coatings on a wood surface were self-assembled by thermally assisted gravity deposition of these microspheres. Chemical compositions and structures of microspheres and morphological characteristics of microspheres and structural color coatings, as well as optical properties of coatings and their generated structural colors, were studied. Pure PSt microspheres had a smooth surface and uniform structure, while microspheres of copolymers had core–shell morphologies and a rough surface. Only poly(styrene-acrylic acid) (P(St-AA)) microspheres had good monodispersity and the resulting coating had a well-ordered photonic crystal structure. However, other kinds of microspheres could form short ranges of ordered amorphous photonic crystal structures and they displayed structural colors. Both the reflectivity of coatings to visible light and structural colors varied with microsphere size and self-assembly temperature.
Plasma Enhanced Fluorine-Free Superhydrophobic Polyester (PET) Fabric with Ultra-Robust Antibacterial and Antibacterial Adhesion Properties
Authors: Lai Yuling , Guo Ying , Xu Liyun , Chang Xijiang , Zhang Xingqun , Xu Guangbiao , Shi Jianjun
Published: December 2020

Superhydrophobic antibacterial fabric possesses properties of antibacterial and antibacterial adhesion and shows huge demand in the field of medical textiles. However, current technologies are unable to fully address this. Hence, a simple method is highly desirable. Herein, the pristine polyester (PET) fabric is immersed into the solution containing ZnO nanoparticle and polydimethylsiloxane (PDMS), and the fiber surfaces are uniformly covered by a ZnO-PDMS layer after being treated by low pressure Ar plasma. The weight gain rate of the treated fabric is 3.5%, which is basically unchanged, and the air permeability, moisture permeability, and tensile properties of the fabric are basically not affected. It is found that the water contact angle (WCA) of the fabric is over 162.7°and sliding angle (SA) is less than 10°. The stable binding of PDMS and PET fibers induces a robust superhydrophobicity; even after 300 washing cycles and 600 friction cycles, it still remains superhydrophobic. The antibacterial rates of Escherichia coli and Staphylococcus aureus before washing were 99.89% and 99.85%, respectively, and after 100 cycles of washing, the antibacterial rates decreased to 99.36% and 99.17%, respectively. Therefore, it shows a good development prospect in the application of protecting clothing or textiles that require good antibacterial properties (such as bed sheets, duvet covers, etc.).
Assessing of the Road Pavement Roughness by Means of LiDAR Technology
Authors: De Blasiis Maria Rosaria , Di Benedetto Alessandro , Fiani Margherita , Garozzo Marco
Published: December 2020

The assessment of the road roughness conditions plays an important role to ensure the required performances related to road safety and ride comfort, furthermore providing a tool for pavement maintenance and rehabilitation planning. In this work, the authors compared the roughness index (International Roughness Index, IRI) derived from high speed inertial profilometer with two other roughness indices, one dynamic and one geometric computed on a digital elevation model (DEM) built by using mobile laser scanner (MLS) data. The MLS data were acquired on an extra-urban road section and interpolated on the nodes of a DEM with a curvilinear abscissa, coinciding with the global navigation satellite system (GNSS) track of the profilometer. To estimate the grid cell elevation, we applied two interpolation methods, ordinary kriging (OK) and inverse distance weighting (IDW), over the same data. The roughness values computed on the surface of the DEM showed a similar trend and a high correlation with those acquired by the profilometer, higher for the dynamic index than for the geometric index. The differences between the IRI values by profilometer and those computed on the DEM were small enough not to significantly affect the judgments on the analyzed sections. Moreover, the road sub-sections derived from profilometer measure that were classified as critical coincided with those derived from light detection and ranging (LiDAR) surveys. The proposed method can be used to perform a network-level analysis. In addition, to evaluate the effects of vibrations on human comfort, we input the DEMs into a dynamic simulation software in order to compute the vertical accelerations, as specified in the UNI ISO 2631 standard. The values obtained were in line and correlated with those inferred from the standard methodology for profilometer measures.
Dissimilar Friction Stir Lap Welding of Al to Mg: Characteristic Signal, Microstructure and Mechanical Properties
Authors: Zhao Yadong , Luo Yalong , Zhang Haixiao , Guo Xuefeng , Wang Shuguang , Cui Hongbao , Zhang Yangming , Wang Zhigang , Zhai Yafang
Published: December 2020

The spindle characteristic signal (forces and vibrations) at different friction stir lap welding (FSLW) parameters were studied. The result indicated that the spindle force and vibration have different trends with the change of welding parameters. For further study, the spindle dynamic performance evaluation model by means of the Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS method) was established. The model was used to calculate the relative approach degree B under different welding process parameters. The correlation between the characteristic signal and the joint properties was obtained. The model was validated by mechanical performance testing and microscopic observation. The results showed that the model evaluations were consistent with the experimental results.
Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
Authors: Wang Linyan , Ashraf Davin C. , Kinde Benyam , Ohgami Robert S. , Kumar Jyoti , Kersten Robert C.
Published: December 2020

We describe a 4-year-old boy who presented with progressive right periorbital edema and proptosis, with no systemic symptoms, who was found to have B-lymphoblastic leukemia (B-ALL). Magnetic resonance imaging (MRI) showed an enhancing mass centered in the right superolateral extraconal orbit. Orbital biopsy was consistent with B-ALL (CD99, TdT, LCA cocktail, CD34, CD79, CD10, PAX5, MIB1 positive; CD3, CD20 negative). A subsequent bone marrow aspirate confirmed a diagnosis of B-ALL with 80% blasts by flow cytometry and haploid cytogenetic findings. The patient improved clinically after chemotherapy. There are seven cases previously reported in the literature with hematogenous orbital masses at initial presentation of childhood ALL, but all with systemic symptoms or an abnormal complete blood count (CBC) at presentation. Our case is the first report in which an orbital mass preceded detectable systemic or laboratory evidence of ALL. This patient highlights the importance of differentiating benign causes of eyelid swelling from malignant ones.
Diagnostic Fine-Needle Biopsy of Small Solid Pancreatic Lesions Using a Franseen Needle during Endoscopic Ultrasound Examination
Authors: Takahashi Kosuke , Yasuda Ichiro , Hanaoka Tatsuyuki , Hayashi Yuka , Araki Yasuhiro , Motoo Iori , Kajiura Shinya , Ando Takayuki , Fujinami Haruka , Tajiri Kazuto , Minemura Masami , Takahara Terumi
Published: December 2020

Background and aim: During endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNB), Franseen needles can help collect sufficient tissue to permit histopathological assessment. However, its efficacy might be limited by the size of the targeted lesion. This study aimed to evaluate the feasibility of histopathological assessment of small solid pancreatic lesions using a 22-gauge Franseen needle during EUS-FNB. Methods: This retrospective study evaluated data from all patients who underwent EUS-FNB using a Franseen needle for solid pancreatic lesions at the University of Toyama Hospital between June 2018 and April 2020. Results: The study included 159 patients who had 152 malignant lesions and 7 benign lesions. The malignant lesions included pancreatic cancers (n = 134), neuroendocrine neoplasms (n = 15), metastatic tumors (n = 2), and a solid pseudopapillary neoplasm (n = 1). The diagnostic accuracy of EUS-FNB (combining histology and cytology) was 98.7%. However, the histopathological diagnosis was only confirmed for 64.3% of small lesions (<10 mm), relative to 97.2% for larger lesions. Multivariate analysis also revealed that lesion size of <10 mm predicted a less accurate histopathological diagnosis (odds ratio: 6.97, 95% confidence interval: 1.02–47.67; p = 0.041). Further analyses revealed a failed histological diagnosis in 4 patients with lesions of <5 mm in size and accurate diagnoses in 9 out of 10 patients with lesions of 5–10 mm in size. Conclusions: The diagnostic accuracy for small lesions (<10 mm), especially for lesions of <5 mm, based on histological examination alone, was significantly lower than that for others (>10 mm). Furthermore, multivariate analysis revealed that only lesion size was an independent predictor of histopathological diagnosis accuracy.
Explainable AI: A Review of Machine Learning Interpretability Methods
Authors: Linardatos Pantelis , Papastefanopoulos Vasilis , Kotsiantis Sotiris
Published: December 2020

Recent advances in artificial intelligence (AI) have led to its widespread industrial adoption, with machine learning systems demonstrating superhuman performance in a significant number of tasks. However, this surge in performance, has often been achieved through increased model complexity, turning such systems into “black box” approaches and causing uncertainty regarding the way they operate and, ultimately, the way that they come to decisions. This ambiguity has made it problematic for machine learning systems to be adopted in sensitive yet critical domains, where their value could be immense, such as healthcare. As a result, scientific interest in the field of Explainable Artificial Intelligence (XAI), a field that is concerned with the development of new methods that explain and interpret machine learning models, has been tremendously reignited over recent years. This study focuses on machine learning interpretability methods; more specifically, a literature review and taxonomy of these methods are presented, as well as links to their programming implementations, in the hope that this survey would serve as a reference point for both theorists and practitioners.
Mutual Coupling Reduction between Finite Spaced Planar Antenna Elements Using Modified Ground Structure
Authors: Sadiq Muhammad Shahzad , Ruan Cunjun , Nawaz Hamza , Abbasi M. Ali Babar , Nikolaou Symeon
Published: December 2020

In this paper, a modified ground structure capable of reducing mutual coupling to provide isolation between adjacent antenna elements is presented. The proposed modified ground structure is a combination of a strategically located ground slot, asymmetric partial ground and a substrate-integrated pin wall. The use of the modified ground structure causes a more than 28 dB (measured value) mutual coupling reduction. The modified ground structure has been optimized and validated with a finite spaced planar 2 × 1 antenna array operating at 4.16 GHz, intended for unmanned aerial vehicle radar altimeter applications. The patch antennas built with the MGS exhibit high gain (greater than 6 dBi throughout the operational band), along with inter-element coupling as low as −65 dB. Mutual coupling reduction at lower contours is beneficial for altimeter applications.
Geomechanics in Depleted Faulted Reservoirs
Authors: Markou Nikolaos , Papanastasiou Panos
Published: December 2020

This paper examines the impact of the effective stresses that develop during depletion of a faulted reservoir. The study is based on finite element modeling using 2D plane strain deformation analysis with pore pressure and elastoplastic deformation of the reservoir and sealing shale layers governed by the Drucker–Prager plasticity model. The mechanical properties and response of the rock formations were derived from triaxial test data for the sandstone reservoirs and correlation functions for the shale layers. A normal fault model and a reverse fault model were built using seismic data and interpretation of field data. The estimated tectonic in-situ stress field was transformed to the plane of the modeled geometry. Sensitivity studies were performed for uncertainties on the values of the initial horizontal stress and for the friction of the fault surfaces. It was found that the stress path during depletion is mainly controlled by the initial lateral stress ratio (LSR). The developed effective stresses with depletion are influenced by the fault geometry of the compartmentalized blocks. Plastic deformation develops for low LSR whereas for high values the system tends to remain in the elastic region. When plastic deformation takes place, it affects mainly the region near the fault. The reservoir deformation is dominated by vertical displacement which is higher near the fault region and nearly uniform in the remote area. The volumetric strain is dominated by compaction. More volatile conditions in relation to change of the friction coefficient and LSR were found for the normal fault geometry.
Numerical Modeling and Optimization of an Air Handling Unit
Authors: Lopes José , Silva João , Teixeira Senhorinha , Teixeira José
Published: December 2020

Concerns about the efficiency of Heating, Ventilating, and Air Conditioning systems, including Air Handling Units (AHUs), started in the last century due to the energy crisis. Thenceforth, important improvements on the AHUs performance have emerged. Among the various improvements, the control of the AHUs and the redesign of the fans are the most important ones. Although, with increasingly demanding energy efficiency requirements, other constructive solutions must be investigated. Therefore, the objective of this work is to investigate, using a computational fluid dynamics (CFD) tool, the fluid flow inside an AHU and to analyze different constructive solutions in order to improve the AHU performance. The numerical model provided a reasonable agreement with the experimental results in terms of air flow rate, despite the assumed simplifications. Regarding the constructive solution concept, the CFD results for the two different flow control units (FCUs) showed improvements in terms of fan static pressure rise. Under real conditions, improvements of 15.1% when compared with the case without the FCU were obtained. Nevertheless, it was concluded that the axial component of the air velocity, at the fan exit, can have a determinant impact on the FCU viability. Finally, an improved FCU geometry, with a new body shape, which resulted in an additional improvement of 6.1% in the fan static pressure rise.
Environmental Assessment of the Vehicle Operation Process
Authors: Mrozik Małgorzata , Merkisz-Guranowska Agnieszka
Published: December 2020

The environmental safety of a car is currently one of the most important indicators of vehicle competitiveness and quality in the consumer market. Currently, assessment of the ecological properties of vehicles is based on various criteria. In the case of combustion-powered cars, most attention is usually paid to the values characterizing their use, and in terms of environmental assessment, pollutant emissions, and operational fuel consumption are key factors. The current article considers the possibility of using the life cycle assessment (LCA) method to analyze the ecological properties of a passenger car during its operation. A simplified LCA method for vehicles, which, in strictly defined cases, can be used for the analysis of environmental impact and assessment of the energy analysis related to its operation, is presented. For this purpose, a vehicle life cycle model is developed. Data on the operation of 33 passenger cars from different manufacturers with similar operational characteristics, coming from different production periods, are analyzed in detail. The vehicle use model takes into account the environmental load due to fuel consumption and pollutant emissions from the internal combustion engine, as well as processes related to the maintenance of the car. The obtained results show that, from the point of view of a car’s impact on the environment throughout its life cycle, the phase of its operation plays the most important role. For the annual operation period, the results of the analysis lead to the conclusion that, in the assessment of energy inputs and related emissions throughout the life cycle of a passenger car, the mileage of the car, which is determined by both the periodicity of replacement of elements and materials subject to normal wear and the length of the adopted period, is of key importance. For the tested vehicles, both the energy input resulting from fuel consumption as well as CO2 and SO2 emissions constitute about 94% to 96% of the total input during the annual operation of the vehicle.
Sustainable Development of the Automobile Industry in the United States, Europe, and Japan with Special Focus on the Vehicles’ Power Sources
Authors: Shigeta Naoya , Hosseini Seyed Ehsan
Published: December 2020

In this paper, various modern power engines developed by the American, Japanese, and European automobile industries will be compared. Specific data, including the efficiency, emission rate of nitrogen oxides (NOx), fuel consumption, and electronic vehicle technology, will be developed. Since the first invention of the automobile engine in the late 19th century, companies came up with unique innovations, including its structure, control systems, and additional mechanical installations to improve efficiency and reduce emissions. Numerous companies, including Ford, Toyota, and Mercedes-Benz, compete in the automobile industry to improve their engine’s efficiency and emission rates to create a clean environment. In addition, each country has its regulations on emission rates and automobile structure. Therefore, to meet these regulations, the structure and the system of the engines vary between companies in different countries. A variety of variable valve timing (VVT) systems, which is a mechanical part installed in the engine, are being developed by several companies. The VVT controls the opening and closing of the air inlet valve and the exhaust valve, which improves the reduction of fuel consumption and thermal efficiency. Furthermore, changing the engine structure is also another method that automobile companies are developing. Changing the engine’s shape can improve the vehicle’s performance (e.g., the engine vibration while running, the power output, and the smoothness of driving). Due to the emissions caused by petrol and diesel engines, the electrified vehicles have been developing to achieve a cleaner environment. This includes battery electric vehicles, hybrid electric vehicles, plug-in hybrid electric vehicles, and fuel cell electric vehicles. By comparing these features in the engine, it is possible to understand what the companies in the US, Japan, and the European countries are working on to improve their engines and provide a clean environment.
Experimental Investigation on the Thermoacoustic Effect in Easily Accessible Porous Materials
Authors: Kajurek Jakub , Rusowicz Artur
Published: December 2020

Thermoacoustic devices are the systems which use acoustic power to transport heat through a stack in a resonance tube. The stack is one of the most important parts of the thermoacoustic systems. It can have different geometries, like parallel plates, circular pores, or pin arrays. However, the fabrication of stacks with regular geometries is sometimes impractical due to material and assembly costs. These problems can be solved by using stack fabricated with random and easily accessible porous materials. In this paper an experimental investigation on the thermoacoustic effect in easily accessible porous materials is presented. The measurements with the stacks were made in a standing wave device filled with air at atmospheric pressure. The reported results confirm that some of the materials with high porosity can be an alternative to a traditional stack geometries and materials.