bluuebunny/crossref_metadata_2025 huggingface dataset:
A Tool for Performing Automatic Kinematic Analysis on Rock Outcrops
Authors: Taboni Battista , Tagliaferri Iuri Dino , Umili Gessica
Published: November 2022

The assessment of rock outcrops’ predisposition to the main possible kinematisms represents the preliminary step of stability analysis: Markland’s tests for sliding and toppling constitute a milestone due to the ease of use and interpretation of results. Orientation and friction angles of the main discontinuity sets and orientation of rock faces are required as input to perform the test on a stereonet graphically. However, for natural outcrops, the orientation of rock faces could vary significantly, and the test should be performed assuming all the representative ones. To speed up this process, the authors set up an automatic procedure based on the GIS environment working principles and developed it in Matlab language. Main discontinuity sets orientation and relative friction angles, along with slope and aspect data representing the rockface orientation of the considered outcrop, are the input data. The slope and aspect data are in GeoTIFF format, the most common format for georeferenced raster files employed in a GIS environment. The Matlab code performs Markland’s tests for planar and wedge sliding and flexural toppling, considering all the possible sets or intersections of sets, and provides the output with the same extent and georeferencing of the input data. The outputs are a series of GeoTIFF raster files describing the result for each kinematism separately and globally, which can be imported directly into GIS. The global results can also be used to map source areas for 3D rockfall numerical simulations. The code was validated through a case study by comparing its results with those obtained by performing the conventional tests singularly on a number of significant rock faces. The results obtained in the case study show that the algorithm produces reliable results consistent with those provided by traditional methods.
Learning Curves in Pediatric Robot-Assisted Pyeloplasty: A Systematic Review
Authors: Pakkasjärvi Niklas , Krishnan Nellai , Ripatti Liisi , Anand Sachit
Published: November 2022

Background: Robot-assisted surgery demands a specific skillset of surgical knowledge, skills, and attitudes from the robotic surgeon to function as part of the robotic team and for maximal utility of the assistive surgical robot. Subsequently, the learning process of robot-assisted surgery entails new modes of learning. We sought to systematically summarize the published data on pediatric robot-assisted pyeloplasty (pRALP) to decipher the learning process by analyzing learning curves. Methods: This review followed the PRISMA guidelines. PubMed, EMBASE, Web of Science, and Scopus databases were systematically searched for ‘learning curve’ AND ‘pediatric pyeloplasty’. All studies presenting outcomes of learning curves (LC) in the context of pRALP in patients < 18 years of age were included. Studies comparing LC in pRALP versus open and/or laparoscopic pyeloplasty were also included; however, those solely focusing on LC in non-robotic approaches were excluded. The methodological quality was assessed using the Newcastle and Ottawa scale. Results: Competency was non-uniformly defined in all fifteen studies addressing learning curves in pRALP. pRALP was considered safe at all stages. Proficiency in pRALP was reached after 18 cases, while competency was estimated to demand 31 operated cases with operative duration as outcome variable. Conclusions: Pediatric RALP is safe during the learning process and ‘learning by doing’ improves efficiency. Competencies with broader implications than time must be defined for future studies.
PRAME Immuno-Expression in Cutaneous Sebaceous Carcinoma: A Single Institutional Experience
Authors: Cazzato Gerardo , Colagrande Anna , Ingravallo Giuseppe , Lettini Teresa , Filoni Angela , Ambrogio Francesca , Bonamonte Domenico , Dellino Miriam , Lupo Carmelo , Casatta Nadia , Resta Leonardo , Maiorano Eugenio , Cascardi Eliano , Marzullo Andrea
Published: November 2022

Background: In recent years, great research interest has been directed to the diagnostic, therapeutic and marker role of Preferentially expressed Antigen in Melanoma (PRAME) in the setting of various human neoplasms. Although it has been extensively studied mainly in the differential diagnosis setting of melanocytic pigmented lesions, still very few papers have analyzed the usefulness or otherwise of PRAME in the context of other non-melanoma skin cancers (NMSC). (2) Methods: In this paper, we report the data of our experience of 21 cases of sebaceous carcinoma (SC) classified in the three WHO grade and collected in the period between January 2005 and 31 October 2022, on which immunostaining for PRAME was performed; Non-parametric Mann–Whitney test for non-normally distributed values was performed. A comparison was made of the means between the three study groups (grade I, II and III). A value of p ≤ 0.05 was set as statistically significant (3) Results: Only seven cases (33.3%) were positive with an immunoscore of 2+/3+ for intensity and 1+/2+ for percentage cells positivity, while 14 cases (66.6%) were totally or nearly totally negative for PRAME with a few of sebaceous-like cells positive with an immunoscore of 1+. Eight cases of SC grade I were immunostaining for PRAME, a level of the cytoplasm of foci of sebaceous differentiation with a significant statical value (p < 0.0001) with respect to ten cases of SC grade II; furthermore, the eight cases of grade I were positive for PRAME in the same areas respect the 3 cases of SC grade III (p = 0.0303). There were no statistical significance between the 10 cases of grade II and 3 cases of grade III (p = 0.2028); (4) Conclusions: PRAME not seems to add particular information in the case of histopathological diagnostics of SC where other markers, including adipophylline, can be quite indicative. It seems, on the other hand, that PRAME can be useful in the subclassification setting of sebaceous carcinoma in grades I–II–III according to the directives of the latest WHO 2018, highlighting the foci of mature sebaceous differentiation most present in grades 1–2 and almost completely absent in grade 3 of the SC.
Reduction of Ischemic Stroke Associated Disability in the Population: A State-Wide Stroke Registry Analysis over a Decade
Authors: Foerch Christian , Schaller-Paule Martin A. , Steinmetz Helmuth , Misselwitz Björn , Bohmann Ferdinand O.
Published: November 2022

(Background): Effective prevention strategies and acute therapies have been established and distributed in recent years to reduce the global burden of stroke. However, beyond randomized clinical trials, limited data exist on the real-world impact of these measures. Our goal was to analyze whether the stroke-associated disability in the population decreased over time based on a state-wide stroke registry analysis. (Methods): Consecutive data from a state-wide inpatient stroke registry covering the entire federal state of Hesse, Germany, were obtained. The clinical data of 141,287 patients with ischemic stroke (ICD-10: I63) admitted between 2010 and 2019 were included. The primary outcome was the odds ratio for a change of modified Ranking Scale (mRS) at discharge over time, estimated by ordinary logistic regression and adjusted for age and sex. The secondary outcome was the odds ratio for a lower National Institutes of Health Stroke Scale (NIHSS) score at hospital admission. (Results): The absolute number of severely disabled (mRS 4–5) stroke patients at discharge decreased over time (2010: 3223 (equivalent to 53/100,000 population); 2019: 2429 [39/100,000 population]). The odds at hospital admission for a higher mRS at discharge decreased significantly by 3.7% per year (OR 0.963 (95% CI 0.960–0.966), p < 0.001). The absolute number of severely affected stroke patients (NIHSS > 15) at admission declined over time (2010: 1589 [26/100,000]; 2019: 1185 [19/100,000]; p < 0.001). The odds for a higher NIHSS score at admission to hospital decreased by 3.8% per year (OR 0.962 (95% CI 0.959–0.965), p < 0.001). Trends were most prominent for patients aged 80 years and older and for patients with atrial fibrillation but absent in patients <60 years. (Conclusions): Stroke-associated disability in the population steadily decreased between 2010 and 2019. The improved prevention of severe strokes in elderly patients may be a major driver of this observation.
Evaluation of Internet-Connected Real-Time Remote Auscultation: An Open-Label Randomized Controlled Pilot Trial
Authors: Ito Takahiro , Hirosawa Takanobu , Harada Yukinori , Kakimoto Shintaro , Shimizu Taro
Published: November 2022

The utility of remote auscultation was unknown. This study aimed to evaluate internet-connected real-time remote auscultation using cardiopulmonary simulators. In this open-label randomized controlled trial, the physicians were randomly assigned to the real-time remote auscultation group (intervention group) or the classical auscultation group (control group). After the training session, the participants had to classify the ten cardiopulmonary sounds in random order as the test session. In both sessions, the intervention group auscultated with an internet-connected electronic stethoscope. The control group performed direct auscultation using a classical stethoscope. The total scores for correctly identified normal or abnormal cardiopulmonary sounds were 97/100 (97%) in the intervention group and 98/100 (98%) in the control group with no significant difference between the groups (p > 0.99). In cardiac auscultation, the test score in the control group (94%) was superior to that in the intervention group (72%, p < 0.05). Valvular diseases were not misclassified as normal sounds in real-time remote cardiac auscultation. The utility of real-time remote cardiopulmonary auscultation using an internet-connected electronic stethoscope was comparable to that of classical auscultation. Classical cardiac auscultation was superior to real-time remote auscultation. However, real-time remote cardiac auscultation is useful for classifying valvular diseases and normal sounds.
Conducting Heritage Tourism-Led Urban Renewal in Chinese Historical and Cultural Urban Spaces: A Case Study of Datong
Authors: Lei Hao , Zhou Youmei
Published: November 2022

Heritage tourism-led urban renewal and regeneration has recently become a critical way of creating a city brand, designing tourism destinations, and attracting property developers and investors to cities. However, current practice points to a lack of proper understanding and consideration in preserving and interpreting elements of authentic identity in the Chinese historic urban landscape. In this study, we used the ancient city of Datong, China, under urban regeneration as a case study to explore how urban history and cultural resources are manifested in preserving and reconstructing historic urban landscapes. The methods included in-depth interviews with multiple stakeholders and groups, integrated with the analysis of planning documents and field observations. By categorising and evaluating the research data, we developed a new conceptual framework with applicable measures, contributing to heritage-tourism urban regeneration and shaping place identity in both theoretical and practical aspects. The conceptual framework and its corresponding concepts and measures developed from this research could provide guidelines for academics and practitioners to explore more potential aspects and concepts that focus on the research and development of Chinese cities with historic urban landscapes.
CRISPR-Based Tools for Fighting Rare Diseases
Authors: Li Qingyang , Gao Yanmin , Wang Haifeng
Published: November 2022

Rare diseases affect the life of a tremendous number of people globally. The CRISPR-Cas system emerged as a powerful genome engineering tool and has facilitated the comprehension of the mechanism and development of therapies for rare diseases. This review focuses on current efforts to develop the CRISPR-based toolbox for various rare disease therapy applications and compares the pros and cons of different tools and delivery methods. We further discuss the therapeutic applications of CRISPR-based tools for fighting different rare diseases.
Quantitative Assessment of Asbestos Fibers in Normal and Pathological Peritoneal Tissue—A Scoping Review
Authors: Caraballo-Arias Yohama , Zunarelli Carlotta , Caffaro Paola , Roccuzzo Francesco , Nocilla Mattia Roberto , Imperiale Maria Chiara , Romano Clara , Boffetta Paolo , Violante Francesco Saverio
Published: November 2022

Peritoneal tissue is the second most affected site by malignant mesothelioma linked to asbestos exposure. This scoping review aims to summarize the findings of the studies in which asbestos fibers in the peritoneum were quantified by electron microscopy, occasionally associated with spectroscopy, both in neoplastic and non-neoplastic tissue. The 9 studies selected comprised 62 cases, out of whom 100 samples were analyzed. Asbestos fibers were detected in 58 samples (58%). In addition, 28 cases had diagnosis of peritoneal mesothelioma. For 32 cases, a lung tumor sample was available: 28/32 samples analyzed presented asbestos fibers; 18/32 reported amphiboles with a range from not detected to 14.2 million fibers per gram of dry tissue (mfgdt); 18/32 reported chrysotile, with a range of 0 to 90 mfgdt. The studies were heterogeneous for type of samples, analytical technology, and circumstances of exposure to asbestos. To evaluate asbestos fibers in the peritoneum and to better understand the association between asbestos exposure and malignant peritoneal mesothelioma, it is desirable that the search for asbestos fibers becomes a routine process every time peritoneal tissue is accessible.
Categorization of Cytochrome P4502D6 Activity Score by Urinary Amphetamine/Methamphetamine Ratios
Authors: Chaichana Jatuporn , Khamenkhetkarn Manee , Sastraruji Thanapat , Monum Tawachai , O’Brien Timothy E. , Amornlertwatana Yutti , Jaikang Churdsak
Published: November 2022

Methamphetamine (MA) level in urine has been used for judgment in MA consumption. Metabolism and intoxication of MA are correlated with the activity of cytochrome P450 2D6 (CYP2D6). The activity score (AS) is a potential tool for predicting exposure and personalized dose of drugs metabolized by CYP2D6. Prediction of the CYP2D6 activity score might be described as MA intoxication. The objective of this study was to categorize the CYP2D6 activity score using the urinary amphetamine (AM)/MA ratio. Urine samples (n = 23,258) were collected. The levels of MA and AM were determined by a gas chromatography–nitrogen–phosphorus detector. The log AS was calculated by an AM/MA ratio and classified into four groups following the percentile position: lower than the 2.5th, the 2.5th–the 50th, the 50th–97.5th, and greater than the 97.5th percentile, respectively. The AS value for males presented was less than 0.024, 0.024–0.141, 0.141–0.836, and greater than 0.836. Meanwhile, the AS values were revealed to be lower than 0.023, 0.023–0.148, 0.148–0.850, and higher than 0.850 for females. The AS value of CYP2D6 can be applied to describe the toxicity of MA in forensic crime scenes and relapse behavior.
The Nexus of Diet, Gut Microbiota and Inflammatory Bowel Diseases in Dogs
Authors: Rhimi Soufien , Kriaa Aicha , Mariaule Vincent , Saidi Amel , Drut Amandine , Jablaoui Amin , Akermi Nizar , Maguin Emmanuelle , Hernandez Juan , Rhimi Moez
Published: November 2022

Canine inflammatory bowel diseases (IBD) are of increasing interest in veterinary medicine. They refer to complex and debilitating conditions of dogs’ gastrointestinal tract. Although little evidence for causal inferences is currently available, it is believed that IBD pathophysiology entails intricate interactions between environmental factors, the intestinal immune system, and the microbial communities that colonize the gut. To better understand the mechanisms underlying these disorders, leveraging factors associated with the development of these diseases is imperative. Of these factors, emerging evidence supports the role of dietary patterns as key players influencing the composition and function of gut microbes, with subsequent effects on health and disease. In this review, we particularly focus on addressing IBD in dogs and discuss how specific nutrients may elicit or relieve gut inflammation. Gaining mechanistic insights into such interplay and the underpinning mechanisms is key to inferring dietary recommendations, and setting up new and promising therapeutics.
Status of Coal-Based Thermal Power Plants, Coal Fly Ash Production, Utilization in India and Their Emerging Applications
Authors: Yadav Virendra Kumar , Gacem Amel , Choudhary Nisha , Rai Ashita , Kumar Pankaj , Yadav Krishna Kumar , Abbas Mohamed , Khedher Nidhal Ben , Awwad Nasser S. , Barik Debabrata , Islam Saiful
Published: November 2022

Both fossil and renewable fuel sources are used widely to produce electricity around the globe. The dependency on fossil fuels for energy leads to the depletion of reserves and various forms of pollution. Coal fly ash (CFA) is one of the most burning issues in the whole world due to its large amount of production in thermal power plants. Every year a million tons (MTs) of CFA are generated globally of which almost half is utilized in various forms, while the remaining half remains unused, leading to various types of pollution. Hence, there is an immediate requirement for CFA management approaches for the efficient and sustainable use of fly ash. In the present review, the authors emphasize the status of energy and its supply and demand. A detailed description of coal fly ash-based thermal power plants, fly ash production, and utilization is provided. Moreover, the current and emerging applications of CFA are also provided.
Molecular Dynamics Simulations of the Mechanical Properties of Cellulose Nanocrystals—Graphene Layered Nanocomposites
Authors: Zhang Xingli , Chen Zhiyue , Lu Liyan , Wang Jiankai
Published: November 2022

Cellulose nanocrystals (CNCs) have received a significant amount of attention due to their excellent physiochemical properties. Herein, based on bioinspired layered materials with excellent mechanical properties, a CNCs-graphene layered structure with covalent linkages (C-C bond) is constructed. The mechanical properties are systematically studied by molecular dynamics (MD) simulations in terms of the effects of temperature, strain rate and the covalent bond content. Compared to pristine CNCs, the mechanical performance of the CNCs-graphene layered structure has significantly improved. The elastic modulus of the layered structure decreases with the increase of temperature and increases with the increase of strain rate and covalent bond coverage. The results show that the covalent bonding and van der Waals force interactions at the interfaces play an important role in the interfacial adhesion and load transfer capacity of composite materials. These findings can be useful in further modeling of other graphene-based polymers at the atomic scale, which will be critical for their potential applications as functional materials.
Micro and Nano Interdigitated Electrode Array (IDEA)-Based MEMS/NEMS as Electrochemical Transducers: A Review
Authors: Kosri Elyana , Ibrahim Fatimah , Thiha Aung , Madou Marc
Published: November 2022

Micro and nano interdigitated electrode array (µ/n-IDEA) configurations are prominent working electrodes in the fabrication of electrochemical sensors/biosensors, as their design benefits sensor achievement. This paper reviews µ/n-IDEA as working electrodes in four-electrode electrochemical sensors in terms of two-dimensional (2D) planar IDEA and three-dimensional (3D) IDEA configurations using carbon or metal as the starting materials. In this regard, the enhancement of IDEAs-based biosensors focuses on controlling the width and gap measurements between the adjacent fingers and increases the IDEA’s height. Several distinctive methods used to expand the surface area of 3D IDEAs, such as a unique 3D IDEA design, integration of mesh, microchannel, vertically aligned carbon nanotubes (VACNT), and nanoparticles, are demonstrated and discussed. More notably, the conventional four-electrode system, consisting of reference and counter electrodes will be compared to the highly novel two-electrode system that adopts IDEA’s shape. Compared to the 2D planar IDEA, the expansion of the surface area in 3D IDEAs demonstrated significant changes in the performance of electrochemical sensors. Furthermore, the challenges faced by current IDEAs-based electrochemical biosensors and their potential solutions for future directions are presented herein.
Effects of Different Parts of the Okra Plant (Abelmoschus esculentus) on the Phytosynthesis of Silver Nanoparticles: Evaluation of Synthesis Conditions, Nonlinear Optical and Antibacterial Properties
Authors: Deen G. Roshan , Hannan Fatima Al , Henari Fryad , Akhtar Sultan
Published: November 2022

In this work, stable and spherical silver nanoparticles (AgNPs) were synthesized in situ from silver salt (silver nitrate) using the aqueous extract of the okra plant (Abelmoschus esculentus) at room temperature and ambient pH conditions. The influences of different parts of the plant (such as the leaves, stems, and pods) on the chemical-reducing effectiveness of silver nitrate to silver nanoparticles were investigated. The aqueous extract of the leaves was found to be more effective in the chemical reduction of silver nanoparticles and in stabilizing them at the same time. The silver nanoparticles produced were stable and did not precipitate even after storage for 1 month. The extract of the stem was less effective in the reduction capacity followed by the extract of the pods. The results indicate that the different amounts of phytochemicals present in the leaves, stems, and pods of the okra plant are responsible for the chemical reduction and stabilizing effect. The silver nanoparticles were characterized by UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX). The surface plasmon resonance (SPR) peak at 460 nm confirmed the formation of silver nanoparticles. The nanoparticles were spherical with an average size of 16 nm and polycrystalline with face-centered cubic (fcc) structures. The z-scan technique was used to study the nonlinear refraction and absorption coefficients of AgNPs at wavelengths of 488 and 514 nm under C.W. mode excitation. The nonlinear refraction index and nonlinear absorption coefficients were calculated in the theoretical equations in the experimental data. The antibacterial properties of the nanoparticles were evaluated against Gram-positive and Gram-negative bacteria.
Enhanced Photoluminescence of Gd3Al4GaO12: Cr3+ by Energy Transfers from Co-Doped Dy3+
Authors: Zhang Yu , Li Xiang , Hu Dahai , Sa Qier , Wang Xinran , Wang Fengxiang , Wang Kaixuan , Zhou Xuelian , Song Zhiqiang , Liu Yongfu , Chao Kefu
Published: November 2022

LEDs for plant lighting have attracted wide attention and phosphors with good stability and deep-red emission are urgently needed. Novel Cr3+ and Dy3+ co-doped Gd3Al4GaO12 garnet (GAGG) phosphors were successfully prepared through a conventional solid-state reaction. Using blue LEDs, a broadband deep-red emission at 650–850 nm was obtained due to the Cr3+ 4T2 → 4A2 transition. When the Cr3+ concentration was fixed to 0.1 mol, the crystal structure did not change with an increase in the Dy3+ doping concentration. The luminous intensity of the optimized GAGG:0.1Cr3+, 0.01Dy3+ was 1.4 times that of the single-doped GAGG:0.1Cr3+. Due to the energy transfer from Dy3+ to Cr3+, the internal quantum efficiency reached 86.7%. The energy transfer from Dy3+ to Cr3+ can be demonstrated through luminescence spectra and fluorescence decay. The excellent properties of the synthesized phosphor indicate promising applications in the agricultural industry.
Green Synthesis of Silver Nanoparticles Using Randia aculeata L. Cell Culture Extracts, Characterization, and Evaluation of Antibacterial and Antiproliferative Activity
Authors: Bernabé-Antonio Antonio , Martínez-Ceja Alejandro , Romero-Estrada Antonio , Sánchez-Carranza Jessica Nayelli , Columba-Palomares María Crystal , Rodríguez-López Verónica , Meza-Contreras Juan Carlos , Silva-Guzmán José Antonio , Gutiérrez-Hernández José Manuel
Published: November 2022

The demand for metallic nanoparticles synthesized using green methods has increased due to their various therapeutic and clinical applications, and plant biotechnology may be a potential resource facilitating sustainable methods of AgNPs synthesis. In this study, we evaluate the capacity of extracts from Randia aculeata cell suspension culture (CSC) in the synthesis of AgNPs at different pH values, and their activity against pathogenic bacteria and cancer cells was evaluated. Using aqueous CSC extracts, AgNPs were synthesized with 10% (w/v) of fresh biomass and AgNO3 (1 mM) at a ratio of 1:1 for 24 h of incubation and constant agitation. UV-vis analysis showed a high concentration of AgNPs as the pH increased, and TEM analysis showed polydisperse nanoparticles with sizes from 10 to 90 nm. Moreover, CSC extracts produce reducing agents such as phenolic compounds (162.2 ± 27.9 mg gallic acid equivalent/100 g biomass) and flavonoids (122.07 ± 8.2 mg quercetin equivalent/100 g biomass). Notably, AgNPs had strong activity against E. coli, S. pyogenes, P. aeruginosa, S. aureus, and S. typhimurium, mainly with AgNPs at pH 6 (MIC: 1.6 to 3.9 µg/mL). AgNPs at pH 6 and 10 had a high antiproliferative effect on cancer cells (IC50 < 5.7 µg/mL). Therefore, the use of cell suspension cultures may be a sustainable option for the green synthesis of AgNPs.
Chitosan-Mediated Environment-Friendly Synthesis of Gold Nanoparticles with Enhanced Photonic Reactivity
Authors: Cazacu Ana , Dobromir Marius , Chiruță Ciprian , Ursu Elena-Laura
Published: November 2022

We developed a very simple, efficient and environment-friendly synthesis method for the manufacturing of high-performance chitosan-capped gold nanoparticles that could be used for biosensing applications. Gold nanoparticles were prepared through the spontaneous reduction of chloroauric acid by chitosan, which was used as both a reducing and a stabilizing agent. The samples were heated to a temperature of 60 °C under ultrasonic conditions. The composite system made of chitosan as a matrix and gold nanoparticles demonstrated a high stability in an aqueous buffer solution. The nanoparticles displayed an enhancement in photonic performance compared with the same property of individual components as a result of surface plasmon resonance at the interface between the structural phases of the hybrid structure. The enhanced photonic reactivity of the hybrid nanostructure may offer new insights for future possible biosensing applications.
Iron Status Affects the Zinc Accumulation in the Biomass Plant Szarvasi-1
Authors: Kolberg Flóra , Tóth Brigitta , Rana Deepali , Arcoverde Cerveira Sterner Vitor , Gerényi Anita , Solti Ádám , Szalóki Imre , Sipos Gyula , Fodor Ferenc
Published: November 2022

Thinopyrum obtusiflorum (syn. Elymus elongatus subsp. ponticus) cv. Szarvasi-1 (Poaceae, Triticeae) is a biomass plant with significant tolerance to certain metals. To reveal its accumulation capacity, we investigated its Zn uptake and tolerance in a wide range: 0.2 to 1000 µM Zn concentration. The root and shoot weight, shoot length, shoot water content and stomatal conductance proved to be only sensitive to the highest applied Zn concentrations, whereas the concentration of malondialdehyde increased only at the application of 1 mM Zn in the leaves. Although physiological status proved to be hardy against Zn exposure, shoot Zn content significantly increased in parallel with the applied Zn treatment, reaching the highest Zn concentration at 1.9 mg g−1 dry weight. The concentration of K, Mg and P considerably decreased in the shoot at the highest Zn exposures, where that of K and P also correlated with a decrease in water content. Although the majority of microelements remained unaffected, Mn decreased in the root and Fe content had a negative correlation with Zn both in the shoot and root. In turn, the application of excessive EDTA maintained a proper Fe supply for the plants but lowered Zn accumulation both in roots and shoots. Thus, the Fe-Zn competition for Fe chelating phytosiderophores and/or for root uptake transporters fundamentally affects the Zn accumulation properties of Szarvasi-1. Indeed, the considerable Zn tolerance of Szarvasi-1 has a high potential in Zn accumulation.
Ulosarcina terrestrica gen. nov., sp. nov., a New Ulvophycean Sarcinoid Alga from the Russian Far East
Authors: Gontcharov Andrey A. , Nikulin Arthur Yu. , Nikulin Vyacheslav Yu. , Allaguvatova Rezeda Z. , Bagmet Veronika B. , Abdullin Shamil R.
Published: November 2022

Many filamentous and sarcinoid terrestrial or freshwater green algae that were previously assigned to the Chlorophyceae are members of lineages belonging to the class Ulvophyceae. One of these lineages is the Planophila-clade (Ulotrichales). Some genera in this clade share similar morphology: cell packages forming branched pseudofilaments, uniseriate or sometimes biseriate filaments, often embedded in common mucilage. During a study on soil algal diversity in the temperate monsoon climate zone in Russia (Primorsky Territory, Vladivostok), we isolated a strain of sarcinoid green alga and examined it using an integrative approach. SSU and ITS rDNA sequence data, morphological characteristics, and life cycle features differentiated this strain from closely related genera of the order Ulotrichales and led us to describe it as Ulosarcina terrestrica gen. et sp. nov.
Creativity and Social Capital: The Pillars of Venice’s Success in the New European Bauhaus Programme
Authors: Busacca Maurizio , Paladini Roberto
Published: November 2022

This article explores six craft-based urban social innovation initiatives implemented in Venice between 2014 and 2021, considered decisive for the candidature of the city in the New European Bauhaus programme. Adopting a qualitative approach based on multiple case study methods, it reconstructs how the promotion of traditional craft enterprises entered the local policy agenda through mechanisms that strengthen the embeddedness of the issue. The article emphasises the polycentrism of social innovation initiatives and highlights the importance of creativity as a tool to trigger co-design processes, of the projects as contexts for knowledge and information sharing, and of events and happenings as contexts for strengthening social capital and increasing its accessibility. In the final part of the paper, some limitations that are emerging and new research lines for the future are suggested.
NLP-Based Application for Analyzing Private and Public Banks Stocks Reaction to News Events in the Indian Stock Exchange
Authors: Dogra Varun , Alharithi Fahd S. , Álvarez Roberto Marcelo , Singh Aman , Qahtani Abdulrahman M.
Published: November 2022

This is an effort to analyze the reaction of stock prices of Indian public and private banks listed in NSE and BSE to the announcement of seven best case news events. Several recent studies have analyzed the correlation between stock prices and news announcements; however, there is no evidence on how private and public sector Indian bank stocks react to important news events independently. We examine these features by concentrating on a sample of banking and government news events. We classify these news events to create a group of negative and a group of positive tone of announcements (sentiments). The statistical results show that the negative banking news announcements had a one-month impact on private banks, with statistically significant negative mean CARs. However, with highly statistically substantial negative mean CARs, the influence of the negative banking news announcements on public banks was observed for two months after the news was published. Furthermore, the influence of the positive banking news on private banks persisted a month after the news was published. Positive banking news events had an influence on public banks for five days after they were published. The study concludes that public bank stocks react more to negative news announcements than positive news announcements in the same manner as the sentimental polarity of the news announcements as compared to private bank stocks. First, we retrieved the news articles published in prominent online financial news portals between 2017 and 2020, and the seven major news events were extracted and classified using multi-class text classification. The Random Forest classifier produced a significant accuracy of 94% with pre-trained embeddings of DistilBERT, a neural network model, which outperformed the traditional feature representation technique, TF-IDF. The training data for the classifier were balanced using the SMOTE sampling technique.
Epidemiologia, biologia, resistência a antifúngicos e virulência do fungo emergente Candida auris
Authors: Pereira Creidvani Martins , De Barros Neuza Biguinati , Martins Tamara Silva
Published: November 2022

Introdução: A Candida auris é uma nova espécie de patógeno fúngico altamente resistente e emergente que causa infecções invasivas graves. O objetivo desse estudo é realizar um levantamento sobre o gênero Candida, destacando características gerais, fatores de risco, epidemiologia e tratamento, bem como os mecanismos de resistência aos medicamentos antifúngicos. A epidemiologia das infecções invasivas por C. auris sofreu mudanças dramáticas, assim estabeleceu como um importante causa de morbidade e mortalidade afetando adultos e crianças com uma variedade de fatores de riscos que representa uma nova ameaça nosocomial que exigirá um controle de infecção aprimorado em diversos ambientes de saúde e comunitários. Para combater infecções por C. auris novos métodos de terapia, drogas e ferramentas estão sendo testados como uma demanda urgente. A prevalência de C. auris atinge anualmente números preocupantes, a incidência é prejudicada por estar relacionada as contrariedades na identificação correta. Por isso, estima-se que o número de casos de C. auris seja muito maior do que os dados relatados. Essa informação se justifica devido a gravidade do fungo ser multirresistente e com a complexidade de transmissão e do alto número de pacientes imunocomprometidos suscetíveis ao contágio e desenvolvimento das formas mais graves da doença.
Reconhecimento e manejo clínico de vítimas de violência sexual infantil na atenção primária à saúde: revisão de literatura
Authors: De Melo Andrea Calyane Neves Ferreira , Saraiva Gisele Sampaio , Figueiredo Ariagnes Queiroz , De Souza Filho João Bosco , Santana Jullie de Queiroga , Alencar Mifran Cabral , Albano Ana Caroline Pires Braga , Pereira Wanderson de Almeida
Published: November 2022

A violência sexual infantil reveste-se de singular importância em virtude das consequências para o crescimento e desenvolvimento da criança e do adolescente, além da possibilidade de construção da matriz de reprodução da violência para gerações futuras, a partir da aprendizagem quanto às atitudes violentas. O objetivo do estudo foi analisar o reconhecimento e o manejo clínico das crianças e adolescentes vítimas de violência sexual (VS) na Atenção Primária à Saúde (APS). A metodologia empregada foi a revisão integrativa da literatura, tendo a busca sido efetuada na Scientific Electronic Library Online (SciELO) e na Biblioteca Virtual em Saúde (BVS). Utilizaram-se os descritores, em português e inglês, devidamente indexados conforme os Descritores em Ciências da Saúde: abuso sexual na infância; atenção primária à saúde; childhood sexual abuse; primary health care. Os critérios de inclusão foram: (1) artigos originais; (2) artigos de revisão; (3) artigos redigidos em língua portuguesa ou inglesa; (4) e que disponibilizavam o resumo nas bases de dados. A busca inicial resultou em 123 estudos. Excluídos os que não preencheram os critérios, os que não respondiam à pergunta da pesquisa e as duplicidades, resultaram oito artigos. Poucos estudos clínicos foram encontrados quando comparados aos ensaios teóricos e às revisões de literatura. Os achados recomendam a obtenção de uma história clínica, realização de exame físico e aquisição de exames laboratoriais apropriados. Além disso, são essenciais: determinar a necessidade de reportar a suspeita do abuso; avaliar as consequências físicas, emocionais e comportamentais do VS; fornecer informação aos pais sobre como apoiar seus filhos; e, dependendo de cada caso, encaminhar os pacientes a outros profissionais. Constata-se, portanto, a importância dos médicos e profissionais de saúde familiarizar-se com o tema, podendo, assim, reconhecer precocemente os casos suspeitos e, então realizar o acompanhamento longitudinal das vítimas de abuso sexual infantil.
High Order Thinking Skill in Pre-Service Teachers’ Lesson Plan
Authors: Sa'adah Lailatus , Anjarwati Rosi
Published: November 2022

The preparation and implementation of the Lesson Plan is a reflection of the preparation and process of learning activities. The success of the preparation and implementation of lesson plans will greatly affect student learning outcomes. With the change in the curriculum and its approach that leads to High Order Thinking Skills, the preparation and implementation of lesson plans need to be investigated more deeply so that the quality of lesson plans can meet the expectations of learning objectives in particular and national education goals in general. This study intends to find out more clearly about the quality of the preparation and implementation of lesson plans for students who have taken Lesson Plan and Micro Teaching courses. In addition, this study will also analyze the approach used by students in the preparation and implementation of their lesson plans. Using qualitative methods, this research is content analysis because the purpose of this study is to determine the quality of the preparation of student lesson plans. The results indicate that some students’ Lesson Plan has applied HOTS-based with good quality of completeness aspect.
University Students’ Preferences and Recognition: British English Vs. American English
Authors: Yoestara Marisa , Wahyuni Juwita
Published: November 2022

British English (BrE) or American English (AmE) are two common English varieties known and used in Indonesia in almost all level of formal education, including in university. This study was intended to find out two folds, which are; (1) the varieties of English the university students prefer to use in spelling and pronunciation; and (2) their ability to recognize the differences between these varieties in vocabulary. The design of this study was a descriptive design which involved 30 students of the English Department at the University of Serambi Mekkah from various semesters but with an average level of English capability. Questionnaire and oral test were used as the instruments to find out the students’ preferences of English varieties in spelling and pronunciation; while, written test is used to find out the students’ ability to recognize the difference of vocabulary within the two varieties. The result of the questionnaire and oral test was analysed by using percentage formula to find out which variation was more dominant in both spelling and pronunciation. Meanwhile, the written test result was checked for its true and false answer in order to decide how far the students could recognize the difference of vocabulary between BrE and AmE. The result showed that more than half of the students preferred to use American English variety in terms of spelling and pronunciation, 55.3% and 60.1% respectively. The results of this study also revealed that 65.2% of the university students had the ability to recognize the differences between BrE and AmE in terms of vocabulary.
Inpatient and Outpatient Satisfaction Comparison of Radiology Installation Service Quality at Private Hospital
Authors: Fatimah Mustika , Putri Utami Muslimah , Septi  , Erista Yola , Yayank Lewinsca Maurend
Published: November 2022

The challenge faced by a hospital during undercontrolled the Covid-19 pandemic is to continue to provide health services quality, in this case, radiology installation service, with patient outcomes being satisfied with the existing services. The purpose of this study was to analyze inpatient and outpatient satisfaction comparison of radiology installation service quality at private hospital. Methods: This analytic survey research used a cross sectional approach. The samples were taken by total sampling method on as many as 30 inpatients and 30 outpatients in private hospital. Statistical data analysis using SPSS Independent T Test for satisfaction comparison and Mann Whitney U Test for various dimensions of service comparison. Results: There was no significant difference in satisfaction (Sig. value 0.136) and various dimensions such as reliability, responsiveness, assurance, empathy, and tangibles of service (Sig. value 0.945; 0.267; 0.134; 0.516; 0.163) between inpatients and outpatients at private hospital. Conclusion: Hospital must improve the quality of all dimensions of radiology installation service to increase all patients satisfaction, not only inpatient but also outpatient satisfaction.
Experienced Lecturers’ Reasoning behind Grammar Feedback Practices in EFL Writing Teacher Education
Authors: Cabot Michel Alexandre
Published: November 2022

Little is known about feedback practices and the reasoning behind grammar feedback in English as a foreign language (EFL) teacher education. This article presents a study based on the interview data of 12 experienced EFL lecturers in Norway. The analysis suggests that the lecturers predominantly use metalinguistic and indirect feedback, while global, focused, oral and elicitative feedback are used far less. Their strategy choices are influenced by multifaceted personal and contextual factors. The personal factors are negative beliefs about elicitations and positive beliefs about metalanguage and autonomy-promoting strategies. The contextual factors include feedback-providing and feedback-receiving situations, formal and informal contexts and the use of common marking code systems. This study contributes to the discussions about how context-dependent and personal factors can shape and improve grammar feedback practices in teacher education. As such, this study highlights a clear need for best practice recommendations specific to EFL writing teacher education.
A Matter of Extreme Indelicacy: Neo-Victorian Critical Memory in Kind Hearts and Coronets (1949)
Authors: Oyarzun Eduardo Valls
Published: November 2022

Critical assessments of Robert Hamer’s Kind Hearts and Coronets (1949) more often than not aim solely at discussing a larger cultural phenomenon, to wit, the Ealing Comedies and their impact on post-war Britain. Readings outside this paradigm are scarce. The film, however, engages with several issues the recent phenomena of neo-Victorian fiction and film consistently address. These are the relationship between the past and the present (as well as the capital role memory plays in it), nostalgia as the underlining desire for the new recasting of Victoriana, the reassessment of history through marginal and/or alternative identities, as well as the blatantly post-modern continuous deferral of meaning. This article explores these issues in order to inscribe the film within neo-Victorian aesthetics, not only to update the critical discourse about the film, but also to reveal what the film has to say about neo-Victorian culture.
ESTIMASI PARAMETER DISTRIBUSI BINOMIAL NEGATIF MENGGUNAKAN METODE INFERENSI BAYESIAN
Authors: Laidat Laura Erlinda , Ginting Keristina Br , Putra Ganesha Lapenangga
Published: November 2022

Estimasi parameter merupakan salah satu bentuk dari statistik inferensial. Estimasi parameter terdiri atas estimasi parameter titik dan estimasi parameter interval. Pada penelitian ini akan dilakukan estimasi parameter titik dan interval dari distribusi Binomial Negatif dengan metode Bayes. Metode Bayes dalam penelitian ini memanfaatkan distribusi Beta selaku prior konjugat, distribusi Uniform selaku prior non-konjugat, dan metode Jeffrey selaku prior non-informatif. Untuk mengevaluasi penduga terbaik, metode yang digunkan ialah dengan melihat nilai yang terkecil dari varian posterior dan lebar credible interval bayes. Dalam studi simulasi menggunakan pemrograman R, diperoleh penduga terbaik ialah prior konjugat Beta, sebab memiliki nilai varian posterior yang terkecil dan lebar credible interval Bayes yang terkecil dibandingkan dengan prior non-konjugat Uniform dan prior non-informatif Jeffrey.
PENERAPAN PEWARNAAN GRAF PADA PENJADWALAN WORK FROM HOME (STUDI KASUS KANTOR PENGAWASAN DAN PELAYANAN BEA DAN CUKAI TIPE MADYA PABEAN C BLITAR)
Authors: Hida Amaliya Asyraful , Robby Rizka Rizqi
Published: November 2022

Virus Corona telah mewabah di Indonesia sejak awal Maret dan menyebar luas hampir ke seluruh provinsi di Indonesia yang mengakibatkan perubahan dalam berbagai aspek kehidupan manusia. Berbagai kebijakan telah dikeluarkan untuk meminimalisir penyebaran COVID-19 salah satunya adalah diberlakukannya PSBB (Pembatasan Sosial Berskala Besar), dengan diberlakukannya PSBB, hal ini mengakibatkan terganggunya aktifitas masyarakat karena adanya pembatasan dalam berbagai hal salah satunya kegiatan bekerja. Kantor Bea Cukai Blitar menerapkan Work From Home (WFH) dengan aturan minimal 50 persen orang yang melaksanakan Work From Home (WFH). Penyusunan jadwal WFH (Work From Home) merupakan sebuah contoh penjadwalan yang harus dilakukan oleh KPPBC TMP C Blitar, untuk memecahkan masalah penjadwalan tersebut akan dilakukan analisis menggunakan teori graff yaitu pewarnaan, dan diolah dengan Algoritma Welch-Powell. Algoritma Welch-Powell dapat digunakan untuk mewarnai sebuah graf G secara efisien. Dari penelitian yang dilakukan dengan menggunakan algoritma Welch-Powell untuk mewarnai penjadwalan WFH menghasilkan penyusunan jadwal yang lebih efektif. Didapatkan hasil bahwa pewarnaan titik pada Subbagian Umum dihasilkan empat warna dengan bilangan kromatik 4, pewarnaan titik pada Seksi Penindakan dan Penyidikan menghasilkan empat warna dengan bilangan kromatik 4, pewarnaan  titik pada Seksi Perbendaharaan menghasilkan 5 warna dengan bilangan kromatik 5, pewarnaan titik pada Seksi KIP menghasilkan 4 warna dengan bilangan kromatik 4, serta pewarnaan titik pada Seksi PKCDT menghasilkan empat warna dengan bilangan kromatik 4.
PLATÃO E A RELIGIÃO ARCAICA: CONSIDERAÇÕES SOBRE AS INFLUÊNCIAS PITAGÓRICA, ÓRFICA E DOS MISTÉRIOS ORACULARES
Authors: Curbani Weriquison Simer
Published: November 2022

O estudo tem como proposta apresentar a filosofia (φιλοσοφια) de Platão sob a ótica da influência da tradição religiosa da Grécia arcaica, levando em conta a herança de elementos herdados do pitagorismo, do orfismo, dos poetas antigos, assim como, do culto ao sagrado oriundo dos oráculos. A partir dessa perspectiva, buscaremos mostrar esse viés metafísico do pensamento platônico e sua relação com o divino. Para isso, passaremos por passagens de obras como o Fedon, Fedro, República, Timeu, entre outras, que retratam bem esta vinculação com a sabedoria (σοφια) divina. Passaremos, também, pela questão da doxa (δόξα) e da episteme (έπιστήμη) ilustrando como se dá esse trajeto que vai da ignorância ao conhecimento iniciático.
Que Deus morreu?
Authors: Lopez Jesus Manuel
Published: November 2022

Este artigo examinou o niilismo, que tanto questiona o religioso como abre novos paradigmas para o Ocidente: a superação e morte da metafisica greco-judaico-cristã. Para tal, conhecemos perifericamente o aforismo 125 da obra “A Gaia Ciência”, onde se declara: “Deus morreu”. Procuraremos entender o alcance desta afirmação, tratando elucidar qual Deus morreu. Isto se fez em conexão com a afirmação bíblica “Eu sou”, encontrada em Êxodo 3,14, que indicou o Nome de Deus judeu e cristão. Esta análise é clara em Santo Agostinho, realizando a imbricação do Nome de Deus no encontro cultural judaico-cristão-helênico. Palavras-chave: Metafísica, morte de Deus, Niilismo.