bluuebunny/crossref_metadata_2025 huggingface dataset:
The Reproducibility of Reference Landmarks in the External Acoustic Meatus (EAM) on Cone Beam Computed Tomography (CBCT) Images
Authors: Sanders-Mello Fernanda , Jonkman Ronald E. G. , Baltussen Ynke , Rozema Frederik R. , Koolstra Jan Harm
Published: July 2024

Objective: The aim of the present study is to identify a more reliable reference point in three-dimensional cephalometric analysis to replace the Porion point used in two-dimensional analysis, enhancing the accuracy of assessments. Methods: The methodology assessed potential alternative landmarks for three-dimensional cephalometric analysis. Utilizing a segmenting technique, anatomical landmarks were accurately pinpointed from the external acoustic meatus of 26 Cone Beam Computed Tomography (CBCT) scans. These landmarks were chosen for their clear and unambiguous detectability. To assess reproducibility, each landmark was replicated twice with a one-week interval by a master’s student. Reproducibility was quantitatively evaluated by analyzing the absolute difference per axis. Results: Five possible candidate landmarks were identified: the most anterior, posterior, superior, and inferior points of the external acoustic meatus (EAM) and a notch delineating the epitympanic recess. The reproducibility of pinpointing these landmarks ranged from 0.56 mm to 2.2 mm. The absolute mean differences between measurements were 0.46 mm (SD 0.75) for the most anterior point, 0.36 mm (SD 0.44) for the most posterior point, 0.25 mm (SD 0.26) for the most superior point, 1.11 mm (SD 1.03) for the most inferior point, and 0.78 mm (SD 0.57) for the epitympanic notch. Conclusions: The most superior point of the EAM might successfully replace the Porion as an anatomical reference.
Whole Body Vibration Training Has No Effect on Vascular Endothelial and Inflammatory Markers in Young Healthy Women
Authors: Gattner Halina , Adamiak Justyna , Czerwińska-Ledwig Olga , Mętel Sylwia , Kępińska-Szyszkowska Magdalena , Piotrowska Anna
Published: July 2024

Background: The aim of the study was to comparatively assess the impact of single and repeated whole body vibration training (WBVT) and training without vibration on changes in the concentration of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and high-sensitivity C-reactive protein (hsCRP) in healthy, young, non-training women. Methods: The study involved 46 women (age 20.48 ± 1.72 years), who were divided into three groups: the experimental group participating in WBVT (EVG, n = 17); the comparison group performing the same exercises but without the vibration factor (EXG, n = 12); and the control group, which did not participate in any training (CON, n = 17). The program included participation in 36 training sessions conducted over 12 weeks, with a frequency of 3 times per week. In the EVG and EXG groups, venous blood was collected before and after the first and last training sessions, while in the CON group, blood was collected twice at a 3-month interval. Results: No significant changes were observed in the concentrations of the studied markers either after a single or repeated training session in both experimental groups (p > 0.05). Conclusions: The proposed WBVT protocol appears to be a safe form of exercise that does not induce negative inflammatory reactions. The applied vibration stimulus combined with physical exercises did not initiate pro-angiogenic processes or stimulate eNOS activity in healthy women, suggesting that similar studies should be conducted in individuals with circulatory problems or chronic inflammatory diseases.
Predelivery Haemostatic Biomarkers in Women with Non-Severe Postpartum Haemorrhage
Authors: de Moreuil Claire , Pan-Petesch Brigitte , Mehic Dino , Kraemmer Daniel , Schramm Theresa , Albert Casilda , Trémouilhac Christophe , Lucier Sandy , Galinat Hubert , Le Roux Liana , Gebhart Johanna , Couturaud Francis , Wolberg Alisa S. , Ay Cihan , Pabinger Ingrid
Published: July 2024

Background: Postpartum haemorrhage (PPH) is a frequent complication of childbirth that is difficult to predict. Predelivery coagulation biomarkers may help to guide preventive strategies. Our objective was to evaluate the association of predelivery haemostatic biomarkers with non-severe PPH. Methods: A nested case-control study was conducted within the « Study of Biological Determinants of Bleeding Postpartum » in order to compare different haemostatic biomarkers in plasma from pregnant women with non-severe PPH (cases) and controls without PPH matched for age, body mass index, term, and mode of delivery. Blood was collected at entry in the delivery room. Global haemostatic assays (thrombin generation assay (TGA) and plasmin generation assay (PGA)) were then performed on freshly thawed aliquots of platelet-poor plasma. Results: A total of 370 pregnant women (185 cases and 185 controls) were included. Median [interquartile range] predelivery platelet count was lower in PPH cases than in controls (217 [181–259] versus 242 [196–280] G/L). TGA and PGA parameters were similar between cases and controls. In a subset analysis of vaginal deliveries (n = 144), median predelivery TGA thrombin peak was lower, and median predelivery PGA lag phase was longer in cases compared to controls. In multivariable analysis, only predelivery platelet count was independently associated with non-severe PPH. Conclusions: Predelivery platelet count is associated with non-severe PPH. Differences in other haemostatic parameters are tenuous, questioning their usefulness in predicting non-severe PPH.
Intrauterine Contraceptive Device Migrated in the Urinary Tract: Case Report and Extensive Literature Review
Authors: Varlas Valentin Nicolae , Meianu Andreea Ioana , Rădoi Andra Ioana , Balescu Irina , Bacalbasa Nicolae , Varlas Roxana Georgiana
Published: July 2024

The migration or translocation of an intrauterine device (IUD) in the urinary tract is a rare event. Here, we present the case of a 55-year-old woman who accidentally discovered the ectopic presence of an IUD following a radiological examination for pelvic pain caused by a lumbar discopathy. Over the years, the patient had several IUDs inserted without being able to specify which one had migrated. The removal of the IUD was performed laparoscopically with the minimum resection of the bladder wall and the subsequent cystorrhaphy. The evolution of the patient was favorable. To better analyze these events, we conducted an all-time extensive electronic search of the PubMed database and identified 94 eligible articles, with a total of 115 cases. The literature analysis on the IUD migrations shows either the simultaneous existence of the second IUD or of a maximum number of up to two IUD insertions during the life of patients. Thus, in the presented case, we identified five IUD insertions over time, which explained the chronic inflammatory process by forming an important mass of adherents that included the urinary bladder, uterus, omentum, sigmoid colon, and abdominal wall. Therapeutic management must be adapted to each case depending on the intra/extravesical location of the migrated IUD evaluated by imaging.
Sex Differences in Aortic Stenosis: From the Pathophysiology to the Intervention, Current Challenges, and Future Perspectives
Authors: Springhetti Paolo , Abdoun Kathia , Clavel Marie-Annick
Published: July 2024

Calcific aortic stenosis (AS) is a major cause of morbidity and mortality in high-income countries. AS presents sex-specific features impacting pathophysiology, outcomes, and management strategies. In women, AS often manifests with a high valvular fibrotic burden, small valvular annuli, concentric left ventricular (LV) remodeling/hypertrophy, and, frequently, supernormal LV ejection fraction coupled with diastolic dysfunction. Paradoxical low-flow low-gradient AS epitomizes these traits, posing significant challenges post-aortic valve replacement due to limited positive remodeling and significant risk of patient–prosthesis mismatch. Conversely, men present more commonly with LV dilatation and dysfunction, indicating the phenotype of classical low-flow low-gradient AS, i.e., with decreased LV ejection fraction. However, these distinctions have not been fully incorporated into guidelines for AS management. The only treatment for AS is aortic valve replacement; women are frequently referred late, leading to increased heart damage caused by AS. Therefore, it is important to reassess surgical planning and timing to minimize irreversible cardiac damage in women. The integrity and the consideration of sex differences in the management of AS is critical. Further research, including sufficient representation of women, is needed to investigate these differences and to develop individualized, sex-specific management strategies.
Evaluating Long-Term Outcomes in STEMI Patients with New Left Bundle Branch Block: The Impact of Modifiable Risk Factors
Authors: Anghel Larisa , Tudurachi Bogdan-Sorin , Tudurachi Andreea , Benchea Laura-Cătălina , Clement Alexandra , Zanfirescu Răzvan-Liviu , Sascău Radu Andy , Stătescu Cristian
Published: July 2024

Background/Objectives: Coronary artery disease, a leading global cause of death, highlights the essential need for early detection and management of modifiable cardiovascular risk factors to prevent further coronary events. Methods: This study, conducted at a major tertiary academic PCI-capable hospital in Romania from 1 January 2011 to 31 December 2013, prospectively analyzed 387 myocardial infarction with ST-segment elevation (STEMI) patients to assess the long-term management of modifiable risk factors. This study particularly focused on patients with new-onset left bundle branch block (LBBB) and compared them with a matched control group without LBBB. Results: During median follow-up periods of 9.6 years for LBBB patients and 9.2 years for those without LBBB, it was found that smoking, obesity, and dyslipidemia were prevalent in 73.80%, 71.42%, and 71.42% of the LBBB group, respectively, at baseline. Significant reductions in smoking were observed in both groups, with the LBBB group’s smoking rates decreasing significantly to 61.90% (p = 0.034). Patients with LBBB more frequently achieved low-density lipoprotein cholesterol (LDLc) target levels during the follow-up period (from 71.42% to 59.52%; p = 0.026) compared to the control group (from 66.67% to 71.42%; p = 0.046). Prescription rates for dual antiplatelet therapy (DAPT), angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARBs), beta-blockers, and statins were initially high but then decreased by the follow-up. Statin use was reduced from 97.62% to 69.04% (p = 0.036) in the LBBB group and from 100% to 61.90% (p = 0.028) in the non-LBBB group. This study also highlighted moderate correlations between obesity (r = 0.627, p = 0.040) and subsequent coronary reperfusion in the LBBB group, while dyslipidemia and smoking showed very strong positive correlations across both groups (dyslipidemia: r = 0.903, p = 0.019 for LBBB; r = 0.503, p = 0.048 for non-LBBB; smoking: r = 0.888, p = 0.035 for LBBB; r = 0.517, p = 0.010 for non-LBBB). Conclusions: These findings underscore the crucial need for targeted management of modifiable risk factors, particularly focusing on dyslipidemia and smoking cessation, to improve subsequent coronary reperfusion outcomes post-STEMI, especially in patients with complicating factors like LBBB.
Harmonized Pan-European Time Series for Monitoring Soil Sealing
Authors: Sannier Christophe , Ivits Eva , Maucha Gergely , Maes Joachim , Dijkstra Lewis
Published: July 2024

The European Copernicus Land Monitoring Service (CLMS) has been producing datasets on imperviousness every 3 years since 2006. However, for 2018, the input for the production of the imperviousness dataset was switched from mixed inputs to the Sentinel constellation. While this led to an improvement in the spatial detail from 20 m to 10 m, this also resulted in a break in the time series as the 2018 update was not comparable to the previous reference years. In addition, the European CLMS has been producing a new dataset from 2018 onward entitled CLC+ Backbone, which also includes a sealed area thematic class. When comparing both datasets with sampled reference data, it appears that the imperviousness dataset substantially underestimates sealed areas at the European level. However, the CLC+ dataset is only available from 2018 and currently does not include any change layer. To address these issues, a harmonized continental soil sealing combined dataset for Europe was produced for the entire observation period. This new dataset has been validated to be the best current dataset for monitoring soil sealing as a direct input for European policies with an estimated total sealed area of 175,664 km2 over Europe and an increase in sealed areas of 1297 km2 or 0.7% between 2015 and 2018, which is comparable to previous time periods. Finally, recommendations for future updates and the validation of imperviousness degree geospatial products are given.
Assessment of Rainstorm Waterlogging Disaster Risk in Rapidly Urbanizing Areas Based on Land Use Scenario Simulation: A Case Study of Jiangqiao Town in Shanghai, China
Authors: Xu Hui , Gao Junlong , Yu Xinchun , Qin Qianqian , Du Shiqiang , Wen Jiahong
Published: July 2024

The impact of flooding on cities is becoming increasingly significant in the context of climate change and rapid urbanization. Based on the analysis of the land use changes and rainstorm waterlogging inundation scenarios of Jiangqiao Town from 1980 to 2020, a scenario analysis was conducted to simulate and assess the rainstorm waterlogging disaster risk in 2040 under three land use scenarios (a natural development scenario, Scenario ND; an economic growth scenario, Scenario EG; and an ecological development priority scenario, Scenario EP) and three rainstorm scenarios with return periods of 10, 50, and 100 years. The following results were found: (1) Land use change is a significant factor in the risk of urban rainstorm waterlogging disaster caused by surface runoff and inundation depth change. In particular, the resultant increase in impermeable surfaces such as residential land and industrial land and the decrease in farmland during urbanization would lead to an increase in urban rainstorm waterlogging disaster risk. (2) Under three rainstorm scenarios, the future land use exposure elements and losses are consistent in terms of spatial distribution; from 10-year to 100-year return periods, they manifest as an expansion from the south to the surroundings, especially to the central region of the study area. The locations at risk are mainly distributed in the central and southern regions of Jiangqiao Town. (3) The economic losses are different in different land use scenarios and rainstorm scenarios. In the context of rainstorm scenarios with return periods of 10, 50, and 100 years, the total losses in land use scenario ND are CNY 560 million, CNY 890 million, and CNY 1.07 billion; those in land use scenario EG are CNY 630 million, CNY 980 million, and CNY 1.19 billion; and those in land use scenario EP are CNY 480 million, CNY 750 million, and CNY 910 million. The total losses of land use EP are the lowest by comparison. So, the influence of land use change on the rainstorm waterlogging disaster risk shows obvious differences among different rainstorm scenarios. This study has important reference value for decision making on land use management and flood disaster risk management in rapidly urbanizing areas.
Spatial Identification and Evaluation of Land Use Multifunctions and Their Interrelationships Improve Territorial Space Zoning Management in Harbin, China
Authors: Zhao Yafang , Liu Jiafu , Zhang Jie , Zhang Xiaonan , Li Hongbo , Gao Fengjie , Zhan Yucheng
Published: July 2024

Quantitative assessment and trade-off/synergy analysis of land use multifunctions can effectively identify regional conflicts and dominant functions, providing decision support for promoting sustainable socio-economic and land use development. However, current research in this field still faces challenges due to coarse scale of studies and limited availability of accurate data. Taking Harbin City as a research case, this research employed an improved mutation level method, Pearson correlation analysis, and a multi-scale geographically weighted regression model to comprehensively investigate the profiling of land use multifunctions and their trade-off /synergy relationships. The comparative advantage theory was adopted to identify dominant functional zones using the NRCA index at a grid scale, in order to achieve a territorial spatial functional zoning delineation. The results showed that there were intricate trade-off/synergy relationships among production–living–ecology functions. Moreover, the types and intensity of trade-off/synergy evolved continuously with socio-economic development and regional resource endowment disparities. Due to its exceptional resource endowment, the agricultural dominated, urban dominated, and ecological dominated functional areas accounted for a significant proportion of 29%, 7%, and 26%, respectively. However, owing to the intricate trade-offs/synergies inherent in land use multifunctions, only a mere 2% (agricultural), 1% (urban), and 1% (ecological) of the area were identified as Optimization Guidance Zones. Conversely, Remediation Improvement Zones constituted the largest share at 63% of the total area, with agricultural, urban, and ecological Remediation Improvement Zones accounting for approximately 33%, 12%, and 18%, respectively. Based on the results of the type and intensity of trade-off/synergy among production–living–ecological functions, as well as the dominant zones and the integrated territorial spatial functional zoning delineation, this article provided targeted recommendations for the sustainable development of the region. These recommendations took into account both resource endowment and socio-economic development characteristics specific to the study area. The study aims to contribute to related research gaps, while providing valuable insights for other regional studies.
Preliminary Results of Developing Imaging Complexity Biomarkers for the Incidence of Severe Radiation Pneumonitis Following Radiotherapy in Non-Small Cell Lung Cancer Patients with Underlying Idiopathic Pulmonary Fibrosis
Authors: Hwang Jeongeun , Kim Hakyoung , Kim Sun Myung , Yang Dae Sik
Published: July 2024

Background: Idiopathic pulmonary fibrosis (IPF) has the potential to cause fatal pulmonary toxicity after radiotherapy and can increase the morbidity and mortality of non-small-cell lung cancer (NSCLC) patients. In this context, we aimed to develop imaging complexity biomarkers to predict the incidence of severe pulmonary toxicity in patients with NSCLC who have underlying IPF and are treated with radiotherapy. Methods: We retrospectively reviewed the medical records of 19 patients with NSCLC who had underlying IPF and were treated with radiotherapy at the Korea University Guro Hospital between March 2018 and December 2022. To quantify the morphometric complexity of the lung parenchyma, box-counting fractal dimensions and lacunarity analyses were performed on pre-radiotherapy simulation chest computed tomography scans. Results: Of the 19 patients, the incidence of grade 3 or higher radiation pneumonitis was observed in 8 (42.1%). After adjusting for age, sex, smoking status, histology, and diffusing capacity of the lung for carbon monoxide, eight patients with a lower fractal dimension showed a significantly higher hazard ratio of 7.755 (1.168–51.51) for grade 3 or higher pneumonitis than those with a higher fractal dimension. Patients with lower lacunarity exhibited significantly lower hazards in all models, both with and without adjustments. The lower-than-median lacunarity group also showed significantly lower incidence curves for all models built in this study. Conclusions: We devised a technique for quantifying morphometric complexity in NSCLC patients with IPF on radiotherapy and discovered lacunarity as a potential imaging biomarker for grade 3 or higher pneumonitis.
Phytochemical Analysis of Centaurea calcitrapa L. Aerial Flowering Parts Serial Solvent Extracts and Its Antibacterial and Antioxidant Activities
Authors: Mekky Alsayed E. , Saied Ebrahim , Abdelmouty Eslam S. , Haggag Muhammad I. , Khedr Mohamed , Khalel Ashjan F. , Al-Habibi Mahmoud M. , Metwally Shimaa A. , El Askary Ahmad , Mohammad Abeer Mahmoud , Alshehri Wafa A. , Sharahili Ahmed I. , Khairy Nehal M. , Abdelaziz Ahmed E. M. , Mahmoud Nashaat N.
Published: July 2024

To evaluate the phytochemical composition, antibacterial, and antioxidant activity of successive extracts of Centaurea calcitrapa L. (C. calcitrapa) aerial flowering parts, they were assessed in vitro. Using a spectrophotometer, the sample absorbance at 517 nm was used to quantify the scavenging activity. The negative control was DPPH. In the current study, the diffusion using agar wells technique was adapted to measure antimicrobial activity. Phytochemical analysis was performed using the recommended standard procedures. The methanol extract of C. calcitrapa exhibited high levels of total phenolic acids expressed as gallic acid (GA), measured as (97.25 ± 0.73 mg GAE/g) content compared to the chloroform, acetyl acetate, and aqueous extracts (27.42 ± 0.29, 64.25 ± 0.96, and 17.25 ± 0.73 mg GAE/g), respectively. Additionally, the methanol extract had a higher total tannin (27.52 ± 0.53 mg TAE/g) content compared to the chloroform, ethyl acetate, and aqueous extracts (12.02 ± 0.55, 26.01 ± 0.81, and 7.35 ± 0.56 mg TAE/g), respectively, while the aqueous extract contains a lower percentage of flavonoids (141.10 ± 1.31 mg RTE/g) compared to the higher content achieved by the methanol extract (425.93 ± 1.27 mg RTE/g). The hydroxyl groups of the flavonoid and the phenolic compounds found in C. calcitrapa are essentially scavenging free radicals. Radical scavenging activity was highest in the methanol extract (IC50 = 2.82 μg/mL), aqueous extract (IC50 = 8.03 μg/mL), ethyl acetate extract (IC50 = 4.79 μg/mL), and chloroform extract (IC50 = 6.33 μg/mL), as compared to the standard scavenging activity (IC50 = 2.52 μg/mL). The antibacterial properties of C. calcitrapa against Gram-negative bacterial strains Klebsiella pneumoniae, Escherichia coli, Enterobacter aerogenes, and Acinetobacter baumanii, in addition to Gram-positive strains Staphylococcus haemolyticus, Enterococcus faecalis, and Staphylococcus aureus, revealed inhibition zone diameter. The findings of this investigation establish that the aerial flowering parts of C. calcitrapa have substantial antibacterial action against human infections, and the plant can serve as a significant antioxidant that can be employed to prevent and treat severe degenerative diseases brought on by oxidative stress. qPCR showed that C. calcitrapa extracts elevate both SOD1 and SOD2 (cellular oxidation markers) with remarkable folds (1.8-fold for SOD1 and SOD2) with ethyl acetate plant extract against ascorbic acid as a control. This result reflects that C. calcitrapa extracts have remarkable antioxidant activity.
Genetic Diversity of Trypanosoma cruzi in the United States of America: The Least Endemic Country for Chagas Disease
Authors: Llovera Arnau , Abras Alba , Fernández-Arévalo Anna , Ballart Cristina , Heras Sandra , Muñoz Carmen , Gállego Montserrat
Published: July 2024

Chagas disease (CD), caused by Trypanosoma cruzi and endemic in Latin America, has become an emergent health problem in non-endemic countries due to human migration. The United States (US) is the non-Latin American country with the highest CD burden and cannot be considered as non-endemic, since triatomine vectors and reservoir animals have been found. Populations of T. cruzi are divided into genetic subdivisions, which are known as discrete typing units (DTUs): TcI to TcVI and TcBat. Autochthonous human T. cruzi infection in the US is sporadic, but it may change due to environmental factors affecting the geographic distribution of triatomines. We aimed to perform a literature review of the genetic diversity of T. cruzi in triatomine vectors and mammalian hosts, including human cases, in the US. The 34 analyzed studies revealed the presence of T. cruzi in 18 states, which was mainly concentrated in Texas, Louisiana and New Mexico. TcI and TcIV were the principal DTUs identified, being TcI the most genotyped (42.4%; 917/2164). This study represents a first attempt to compile the molecular epidemiology of T. cruzi in the US, which is fundamental for predicting the progression of the infection in the country and could be of great help in its future management.
Optimal Investment Consumption Choices under Mispricing and Habit Formation
Authors: Shi Ailing , Sun Jingyun , Liu Botao
Published: July 2024

This paper studies the optimal consumption and investment for an agent, considering statistical arbitrary opportunities caused by mispriced stocks. The agent exhibits consumption habit formation and has access to a risk-free asset, a market index, and a pair of mispriced stocks. The optimization problem is to find the optimal consumption and investment strategies to maximize the expected utility from consumption and terminal wealth. The utility of consumption stems from the difference between the consumption and habit levels. Based on the dynamic programming method, a verification theorem is provided, and the analytical solution of the optimization problem is obtained. The numerical results show the behaviors of our formulas and are used to make practical recommendations. By studying the sensitivity of consumption and investment strategies to habit formation, mispricing, and a delta-neutral arbitrage strategy, we uncover and analyze the behaviors of the agent. Meanwhile, we define and discuss the wealth-equivalent utility loss in three cases, including ignoring habit formation, ignoring mispricing, and adopting the delta-neutral arbitrage strategy.
A Working Conditions Warning Method for Sucker Rod Wells Based on Temporal Sequence Prediction
Authors: Zhang Kai , Yin Chengzhe , Yao Weiying , Feng Gaocheng , Liu Chen , Cheng Cheng , Zhang Liming
Published: July 2024

The warning of the potential faults occurring in the future in a sucker rod well can help technicians adjust production strategies in time. It is of great significance for safety during well production. In this paper, the key characteristic parameters of dynamometer cards were predicted by a temporal neural network to implement the warning of different working conditions which might result in failures. First, a one-dimensional damped-wave equation was used to eliminate the dynamic loads’ effect of surface dynamometer cards by converting them into down-hole dynamometer cards. Based on the down-hole dynamometer cards, the characteristic parameters were extracted, including the load change, the position of the valve opening and closing point, the dynamometer card area, and so on. The mapping relationship between the characteristic parameters and working conditions (classification model) was obtained by the Xgboost algorithm. Meanwhile, the noise in these parameters was reduced by wavelet transformation, and the rationality of the results was verified. Second, the Encoder–Decoder and multi-head attention structures were used to set up the time series prediction model. Then, the characteristic parameters were predicted in a sequence-to-sequence way by using historical characteristic parameters, date, and pumping parameters as input. At last, by inputting the predicted results into the classification model, a working conditions warning method was created. The results showed that noise reduction improved the prediction accuracy significantly. The prediction relative error of most characteristic parameters was less than 15% after noise reduction. In most working conditions, their F1 values were more than 85%. Most Recall values could be restored to over 90% of those calculated by real parameters, indicating few false negative cases. In general, the warning method proposed in this paper can predict faulty working conditions that may occur in the future in a timely manner.
Stability Analysis, Modulation Instability, and Beta-Time Fractional Exact Soliton Solutions to the Van der Waals Equation
Authors: Qawaqneh Haitham , Manafian Jalil , Alharthi Mohammed , Alrashedi Yasser
Published: July 2024

The study consists of the distinct types of the exact soliton solutions to an important model called the beta-time fractional (1 + 1)-dimensional non-linear Van der Waals equation. This model is used to explain the motion of molecules and materials. The Van der Waals equation explains the phase separation phenomenon. Noncovalent Van der Waals or dispersion forces usually have an effect on the structure, dynamics, stability, and function of molecules and materials in different branches of science, including biology, chemistry, materials science, and physics. Solutions are obtained, including dark, dark-singular, periodic wave, singular wave, and many more exact wave solutions by using the modified extended tanh function method. Using the fractional derivatives makes different solutions different from the existing solutions. The gained results will be of high importance in the interaction of quantum-mechanical fluctuations, granular matters, and other applications of the Van der Waals equation. The solutions may be useful in distinct fields of science and civil engineering, as well as some basic physical ones like those studied in geophysics. The results are verified and represented by two-dimensional, three-dimensional, and contour graphs by using Mathematica software. The obtained results are newer than the existing results. Stability analysis is also performed to check the stability of the concerned model. Furthermore, modulation instability is studied to study the stationary solutions of the concerned model. The results will be helpful in future studies of the concerned system. In the end, we can say that the method used is straightforward and dynamic, and it will be a useful tool for debating tough issues in a wide range of fields.
Radii of γ-Spirallike of q-Special Functions
Authors: Kazımoğlu Sercan
Published: July 2024

The geometric properties of q-Bessel and q-Bessel-Struve functions are examined in this study. For each of them, three different normalizations are applied in such a way that the resulting functions are analytic in the unit disk of the complex plane. For these normalized functions, the radii of γ-spirallike and convex γ-spirallike of order σ are determined using their Hadamard factorization. These findings extend the known results for Bessel and Struve functions. The characterization of entire functions from the Laguerre-Pólya class plays an important role in our proofs. Additionally, the interlacing property of zeros of q-Bessel and q-Bessel-Struve functions and their derivatives is useful in the proof of our main theorems.
Barriers against Implementation of European Society of Gastrointestinal Endoscopy Performance Measures for Colonoscopy in Clinical Practice
Authors: Gibiino Giulia , Frazzoni Leonardo , Anderloni Andrea , Fuccio Lorenzo , Lacchini Alessandro , Spada Cristiano , Fabbri Carlo
Published: July 2024

Background and Objectives: The implementation and monitoring of the European Society of Gastrointestinal Endoscopy (ESGE) performance measures for colonoscopy are suboptimal in clinical practice. Electronic reporting systems may play an important role in data retrieval. We aimed to define the possibility of systematically assessing and monitoring ESGE performance measures for colonoscopy through reporting systems. Materials and Methods: We conducted a survey during a nationwide event on the quality of colonoscopy held in Rome, Italy, in March 2023 by a self-administered questionnaire. Analyses were conducted overall and by workplace setting. Results: The attendance was 93% (M/F 67/26), with equal distribution of age groups, regions and public or private practices. Only about one-third (34%) and 21.5% of participants stated that their reporting system allows them to retrieve all the ESGE performance measures, overall and as automatic retrieval, respectively. Only 66.7% and 10.7% of respondents can systematically report the cecal intubation and the adenoma detection rate, respectively. The analysis according to hospital setting revealed no significant difference for all the items. Conclusions: We found a generalized lack of systematic tracking of performance measures for colonoscopy due to underperforming reporting systems. Our results underline the need to update reporting systems to monitor the quality of endoscopy practice in Italy.
The Complex Role of Mast Cells in Head and Neck Squamous Cell Carcinoma: A Systematic Review
Authors: Tzorakoleftheraki Sofia-Eleni , Koletsa Triantafyllia
Published: July 2024

Background and Objectives: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous malignancy influenced by various genetic and environmental factors. Mast cells (MCs), typically associated with allergic responses, have recently emerged as key regulators of the HNSCC tumor microenvironment (TME). This systematic review explores the role of MCs in HNSCC pathogenesis and their potential as prognostic markers and therapeutic targets. Materials and Methods: A systematic search was conducted in the PubMed, Scopus and ClinicalTrials.gov databases until 31 December 2023, using “Mast cells” AND “Head and neck squamous cell carcinoma” as search terms. Studies in English which reported on MCs and HNSCC were included. Screening, data extraction and analysis followed PRISMA guidelines. No new experiments were conducted. Results: Out of 201 articles, 52 studies met the inclusion criteria, 43 of which were published between 2020 and 2023. A total of 28821 HNSCC and 9570 non-cancerous tissue samples had been examined. MC density and activation varied among normal tissues and HNSCC. Genetic alterations associated with MCs were identified, with specific gene expressions correlating with prognosis. Prognostic gene signatures associated with MC density were established. Conclusions: MCs have arisen as multifaceted TME modulators, impacting various aspects of HNSCC development and progression. Possible site-specific or HPV-related differences in MC density and activation should be further elucidated. Despite conflicting findings on their prognostic role, MCs represent promising targets for novel therapeutic strategies, necessitating further research and clinical validation for personalized HNSCC treatment.
Tracking Metabolite Variations during the Degradation of Vegetables in Rice Bran Bed with Intact-State Nuclear Magnetic Resonance Spectroscopy
Authors: Ito Kengo , Yamamoto Ryusei , Sekiyama Yasuyo
Published: July 2024

Fermentation—a process of compound degradation by microorganisms—is a traditional food processing method utilized worldwide for the long-term preservation of fresh foods. In recent years, fermented foods have gained attention as health foods. Fermentation increases the nutritional value of ingredients, producing complex flavors and aromas. To identify unknown components in fermented foods, it is necessary to analyze compounds and conditions nondestructively and comprehensively. We performed intact-state nuclear magnetic resonance (NMR) spectroscopy using intermolecular single quantum coherence (iSQC) to detect the degradation of vegetables directly and nondestructively. We used two types of vegetables and a rice bran bed (nukazuke), which is used for traditional vegetable fermentation in Japan. Major metabolites such as saccharides, organic acids, and amino acids were identified in iSQC-sliced spectra. Comparing NMR signal intensities during degradation revealed the transition of metabolites characteristic of lactic acid fermentation. A pathway-based network analysis showed pathways involved in amino acid metabolism and lactic acid fermentation. Our analytical approach with intact-state NMR spectroscopy using iSQC demonstrated that it may be effective in other experimental systems, allowing for the evaluation of phenomena that have been conventionally overlooked in their true state.
Bilirubin Levels in Infancy and Their Associations with Body Weight, Levels of Iron-Related Parameters and Steroid Hormone Levels
Authors: Grosse-Thie Charlotte , Vogel Mandy , Baber Ronny , Ceglarek Uta , Kiess Wieland
Published: July 2024

It is assumed that bilirubin is hormonally regulated and influences weight development by preventing weight gain. However, studies in healthy infants are limited. The present study established reference values for bilirubin and investigated whether bilirubin levels are significantly associated with body weight, levels of ferritin and transferrin as well as steroid hormone levels in a study population of three- and six-month-old healthy infants. Data from a total of 411 study visits from the LIFE Child study (Leipzig, Germany) were analyzed. Associations were examined using linear regression analyses. Besides laboratory parameters, anthropometric data were gathered. We found statistically significant associations between body weight and bilirubin levels. In girls, we observed additional associations between bilirubin levels and both ferritin and transferrin concentrations at three months of age. At six months, steroid hormone levels were significantly associated with concentrations of total and indirect bilirubin, with effects differing by sex. Our study thus confirms associations already reported from animal studies and studies in adult populations. Furthermore, we showed that these associations already exist in the first year of life, are influenced by sex and age and, further, depend on the bilirubin type. Our results provide reference values for bilirubin and assist, therefore, in interpreting bilirubin levels in infancy.
Oat Brewery Waste Decreased Methane Production and Alters Rumen Fermentation, Microbiota Composition, and CAZymes Profiles
Authors: Malik Pradeep Kumar , Trivedi Shraddha , Mohapatra Archit , Kolte Atul Purshottam , Mech Anjumoni , Victor Tsuma , Ahasic Elena , Bhatta Raghavendra
Published: July 2024

The transformation of oat brewery waste (OBW) into livestock feed could be a potential replacement for the expensive concentrate and one of the effective approaches for avoiding health hazards due to the accumulation of oat brewery waste in the environment. To explore the potential of OBW as a methane (CH4) mitigating agent, an in vitro study was undertaken to investigate the effect of graded replacement of concentrate with OBW on CH4 production, microbiota, feed fermentation, and CAZymes. A total of five treatments with variable proportions of OBW were formulated. The results indicated a linear decrease in the total gas production and a 38–52% decrease in CH4 production with a 60 and 100% replacement of concentrate with OBW. The inclusion of OBW also affected the abundance of microbes such as Firmicutes, Euryarchaeota, Methanobrevibacter, and protozoa numbers. This study demonstrated that OBW can partially replace the concentrate and effectively mitigate CH4 production; however, the concurrent decrease in fermentation cautioned for the partial replacement of concentrate with OBW at an appropriate level at which the fermentation remains unaffected while decreasing CH4 production. Therefore, waste from oat breweries can contribute to curtailing the accumulation of greenhouse gases (GHGs) in the atmosphere.
Efficient Removal of Methylene Blue Dye from Aqueous Media Using Facilely Synthesized Magnesium Borate/Magnesium Oxide Nanostructures
Authors: Al-Wasidi Asma S. , Hegazey Raed M. , Abdelrahman Ehab A.
Published: July 2024

Methylene blue dye in water sources can pose health risks to humans, potentially causing methemoglobinemia, a condition that impairs the blood’s ability to carry oxygen. Hence, the current study investigates the synthesis of novel magnesium borate/magnesium oxide (Mg3B2O6/MgO) nanostructures and their efficiency in removing methylene blue dye from aqueous media. The nanostructures were synthesized using the Pechini sol–gel method, which involves a reaction between magnesium nitrate hexahydrate and boric acid, with citric acid acting as a chelating agent and ethylene glycol as a crosslinker. This method helps in achieving a homogeneous mixture, which, upon calcination at 600 and 800 °C, yields Mg3B2O6/MgO novel nanostructures referred to as MB600 and MB800, respectively. The characterization of these nanostructures involved techniques like X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, N2 gas analyzer, and field-emission scanning electron microscope (FE-SEM). These analyses confirmed the formation of orthorhombic Mg3B2O6 and cubic MgO phases with distinct features, influenced by the calcination temperature. The mean crystal size of the MB600 and MB800 samples was 64.57 and 79.20 nm, respectively. In addition, the BET surface area of the MB600 and MB800 samples was 74.63 and 64.82 m2/g, respectively. The results indicated that the MB600 sample, with its higher surface area, generally demonstrated better methylene blue dye removal performance (505.05 mg/g) than the MB800 sample (483.09 mg/g). The adsorption process followed the pseudo-second-order model, indicating dependency on available adsorption sites. Also, the adsorption process matched well with the Langmuir isotherm, confirming a homogeneous adsorbent surface. The thermodynamic parameters revealed that the adsorption process was physical, exothermic, and spontaneous. The MB600 and MB800 nanostructures could be effectively regenerated using 6 M HCl and reused across multiple cycles. These findings underscore the potential of these nanostructures as cost-effective and sustainable adsorbents for methylene blue dye removal.
Physical and Functional Properties of Powders Obtained during Spray Drying of Cyani flos Extracts
Authors: Lisiecka Katarzyna , Dziki Dariusz , Karaś Monika
Published: July 2024

Edible flowers are a potential source of bioactive ingredients and are also an area of scientific research. Particularly noteworthy are Cyani flos, which have a wide range of uses in herbal medicine. The below study aimed to investigate the influence of selected soluble fiber fractions on the selected properties of physical and biochemical powders obtained during spray drying a water extract of Cyani flos. The drying efficiency for the obtained powders was over 60%. The obtained powders were characterized by low moisture content (≤4.99%) and water activity (≤0.22). The increase in the addition of pectin by the amount of 2–8% in the wall material resulted in a decrease in hygroscopicity, water solubility, and protection of flavonoids and anthocyanins both before and after digestion in the tested powders in comparison to the sample with only inulin as a carrier. Additionally, it was noted that all samples were characterized by high bioaccessibility when determining antioxidant properties and xanthine oxidase inhibition.
An Evaluation of the Corrosion Inhibition Performance of Chitosan Modified by Quaternary Ammonium Salt for Carbon Steel in Stone Processing Wastewater
Authors: Xiang Jingjing , Mo Chaofan , Peng Chao , Yang Lin , Wan Tingtao , Song Yuntian , Lei Xuanhui , Liu Pu , Gao Bo , Ren Dajun , Zhao Chong , Huang Yanjun , Wang Yi , Zhang Lei
Published: July 2024

Chitosan was used as the raw material. A quaternization reaction was carried out between 2,3-epoxypropyltrimethylammonium chloride and water-soluble chitosan to prepare quaternary ammonium salt water-soluble chitosan (QWSC), and its corrosion inhibition performance against the corrosion of carbon steel in stone processing wastewater was evaluated. The corrosion inhibition efficiencies of QWSC on carbon steel in stone processing wastewater were investigated through weight loss, as well as electrochemical and surface morphology characterization techniques. The results show that QWSC has superior corrosion inhibition performance for A3 carbon steel. When an amount of 60 mL·L−1 is added, the corrosion inhibition efficiency can reach 59.51%. Electrochemical research has shown that a QWSC inhibitor is a mixed-type corrosion inhibitor. The inhibition mechanisms of the QWSC inhibitor revealed that the positive charge on the surface of carbon steel in stone wastewater was conducive to the adsorption of Cl− in the medium, which produced an excessive negative charge on the metal’s surface. At the same time, the quaternary ammonium cation and amino cation formed in QWSC in stone processing wastewater can be physically absorbed on the surface of A3 carbon steel, forming a thin-film inhibitor to prevent metal corrosion.
Adverse Events during Prone Positioning of Patients with COVID-19 during a Surge in Hospitalizations—Results of an Observational Study
Authors: Radovanović Nataša , Krajnc Mateja , Gorenjak Mario , Strdin Košir Alenka , Markota Andrej
Published: July 2024

This study aimed to determine the prevalence of adverse events in mechanically ventilated adults with COVID-19 who have undergone prone positioning. A total of 100 patients were included retrospectively; 60% were males, the mean age was 64.8 ± 9.1 years, and hospital mortality was 47%. In all, we recorded 118 removals of catheters and tubes in 66 patients; 29.6% were removals of a nasogastric tube, 18.6% of an arterial line, 14.4% of a urinary catheter, and 12.7% of a central venous catheter. Reintubation or repositioning of a tracheotomy tube was required in 19 patients (16.1%), and cardiopulmonary resuscitation in 2 patients (1.7%). We recorded a total of 184 pressure ulcers in 79 patients (on anterior face in 38.5%, anterior thorax in 23.3% and any extremity anteriorly in 15.2%). We observed that body weight (p = 0.021; β = 0.09 (CI95: 0.01–0.17)) and the cumulative duration of prone positioning (p = 0.005; β = 0.06 (CI95: 0.02–0.11)) were independently associated with the occurrence of any adverse event. The use of prone positioning in our setting was associated with a greater number of adverse events than previously reported. Body weight and cumulative duration of prone positioning were associated with the occurrence of adverse events; however, other factors during a COVID-19 surge, such as working conditions, staffing, and staff education, could also have contributed to a high prevalence of adverse events.
Histopathological and Virological Findings of a Penile Papilloma in a Japanese Stallion with Equus Caballus Papillomavirus 2 (EcPV2)
Authors: Uchida-Fujii Eri , Kato Yusei , Ueno Takanori , Numasawa Yasuko , Yusa Shigeki , Haga Takeshi
Published: July 2024

Equus caballus papillomavirus 2 (EcPV2) is known to cause genital neoplasms in horses. However, reports on EcPV2 in Japan and Asia are limited. Herein, we present the histopathological and virological findings of the first reported case of an EcPV2-associated penile mass in Japan. The patient was a 22-year-old stallion with a history of breeding in Japan and abroad. Histopathological examination contained RNA in situ hybridization targeting the E6/E7 region and an immunohistochemical approach, and whole-genome sequencing was conducted within the viral examination. Proliferating epidermal cells were observed, and EcPV2 E6/E7 mRNA was detected within the epidermis, which was interpreted as viral papilloma. The detected EcPV2 virus was genetically close to foreign strains and different from the strain previously reported from a Japanese mare. This suggests that various types of EcPV2 might already exist among horses in Japan. Although the mass reported herein was not malignant based on histopathological findings and the absence of recurrence, its presence on the penis would be an obstacle to breeding. These results provide a better understanding of the pathogenesis and diversity of EcPV2.