bluuebunny/crossref_metadata_2025 huggingface dataset:
New Perspectives in Colorectal Cancers Treatment, the Role of MicroRNAs
Authors: Belova Victoria A. , Spirina Liudmila V. , Avgustinovich Alexandra V. , Afanas'ev Sergey G. , Volkov Maxim Y. , Azovsky Daniil I. , Volkov Alexander M. , Klyushina Tatyana S.
Published: July 2024

:

The main epidemiological and clinical data on colorectal cancer, as well as the features
of molecular pathology, are discussed in the literature review. Efforts are being putto identify
promising targets, particularly small non-coding nucleotide sequences, which can lead to new
treatments for this disease.

:

The discovery of significant mutations that contribute to the development of colorectal tumors is a
major step in the advancement of molecular oncology, as these mutations give rise to heterogeneous
tumors that differ in their origin. These mutations play a significant role in the progression
of the disease and are now being targeted for treatment. The prognosis for a disease is influenced
by the patient's sensitivity to antitumor therapy. However, new approaches to finding effective targets
for antitumor treatments face new fundamental challenges due to clinical issues. These issues
include the epigenetic regulation of markers of oncogenesis, which allows for the development of
new therapeutic strategies.

:

RNA interference, in particular, has been linked to non-copying RNA sequences such as microRNAs.
These microRNAs are associated with certain processes that can influence all aspects of
oncogenesis. The diversity of microRNAs allows for a differentiated approach when treating tumors
in various locations.
Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells
Authors: Zhang Lin , Guo ShuXian , Chang ShuYing , Jiang Guan
Published: July 2024

:

Oncolytic Viruses (OVs) have emerged as a promising treatment option for cancer thanks to their
significant research potential and encouraging results. These viruses exert a profound impact on the tumor microenvironment,
making them effective against various types of cancer. In contrast, the efficacy of Chimeric antigen
receptor (CAR)-T cell therapy in treating solid tumors is relatively low. The combination of OVs and CAR-T cell
therapy, however, is a promising area of research. OVs play a crucial role in enhancing the tumor-suppressive
microenvironment, which in turn enables CAR-T cells to function efficiently in the context of solid malignancies.
This review aims to provide a comprehensive analysis of the benefits and drawbacks of OV therapy and CAR-T
cell therapy, with a focus on the potential of combining these two treatment approaches.
Current Status of Research on Fill Mining Systems
Authors: Wang Wei , Zhang Rui , Huang Qiujiao , Liu Siyu , Liu Yu
Published: July 2024

Background:

With the rapid development of society, the demand for coal in production
and daily life has been growing at an unprecedented rate. However, extensive coal mining has led to
various environmental and safety issues. The gradual depletion of shallow mineral resources, the
increasing depth of mining operations leading to more challenging mining environments, the severe
pollution caused by the accumulation of large amounts of mining waste on the surface, and the continuous
emphasis on green, environmentally friendly, and sustainable development concepts have
necessitated effective solutions. In response to these challenges, the adoption of backfill mining
technology has emerged as a viable approach.

Objective:

This paper offers a comprehensive overview and classification of the methods and mechanical
systems utilized in backfill mining within coal mines. It provides a succinct explanation of
the implementation of diverse backfilling methods in mining activities and the present state of various
backfilling mechanical systems. This information can assist researchers and businesses in understanding
the evolution of filling technology and serve as a crucial foundation for future research and
innovation.

Methods:

An evaluation of Backfill Mining Method Patents and Backfill Mechanical System Patents
and an Introduction to the Advantages and Disadvantages of Different Backfill Methods have
been analyzed.

Results:

Through the analysis and comparison of existing backfill methods, we can summarize the
typical characteristics of each technique. Finally, we discuss the future development trends of backfill
mining.

Conclusion:

Backfill mining can effectively support rock strata, control ground pressure activity,
and protect surface flora and fauna. It can also improve the stress state of mining pillars and maximize
resource recovery. Furthermore, it enables efficient handling of solid waste, reduces production
costs, and achieves green and sustainable development. Each backfill mining system has its advantages
and disadvantages, therefore, it is necessary to consider multiple factors comprehensively in
order to choose the appropriate method.
Lexicosyntactic analysis of fused compounds in Yoruba
Authors: Adekunle Basirat Omolola
Published: July 2024

Compounding is one of the productive word formation processes in human languages due to its eclectic means of formation. This paper focuses on the fused compounding process in Yorùbá. The aim of this study is to analyse the lexicosyntactic process involved in deriving fused compounds in Yorùbá. The paper states the possible combinations of fused compounding in Yoruba; it examines the different processes that can occur at the syntactic level of compounding; and it analysed the processes which occur at the syntactic level of compounding. Data for this study were gathered from the introspection of the researcher since the researcher is a native speaker of the language of the study. Data gathered were validated by other native speakers for accuracy and authentication. Also, data were obtained from previous related literature. The theoretical framework adopted for this study is the weak lexicalist hypothesis. This study found that assimilation, vowel elision and coalescence are the possible alterations which occur at the syntactic level of fused compounding in Yorùbá. This study concludes that fused compounding only surfaces in Noun + Noun (N+N) Noun + Noun + Noun (N+N+N), Affix + Verb + Noun (AFX+V+N) and Verb + Noun (V+N) combinations in the language.
Linguistic and country studies aspect of teaching chinese language to bachelors (using the example of gastronomic culture)
Authors: Kartashova V. N. , Weihan Zhang
Published: July 2024

Summary. The article examines the theoretical and technological aspects of the linguistic and cultural approach to teaching pedagogical students studying Chinese.

The purpose of this article is to describe a strategy for studying the topic of Chinese gastronomic culture in practical classes, the features of its influence on the Chinese language from the perspective of linguistic and regional studies. The authors explain the difficulties of learning the Chinese language, list the main problems that students have in the lexico-grammatical, phonemic and cultural terms of mastering the Chinese language. Particular attention is paid to the linguistic and cultural aspect of language acquisition. Modern linguistics considers language not just as a means of communication, but also as a “cultural code of a nation.” By studying a foreign language, the student also studies the culture of the people speaking this language, mastering not only the word, but also a typified image in the national consciousness of the people - the bearer of the language and culture.

During the research process general scientific methods of cognition (analysis, synthesis, generalization) were used. A selection, analysis and synthesis of theoretical and practical publications on the technological aspects of the linguistic and regional approach to teaching a foreign language was carried out.

The article presents the organization of students' mastery of cultural content within the framework of studying the topic of Chinese gastronomic culture in language practice classes. The authors emphasize that for the linguistic and professional training of a future bachelor it is very important to build the process of teaching Chinese correctly from a linguistic and methodological position. In the linguistic aspect, students’ awareness and mastery of realities, skills in operating these units and non-verbal means of communication in the process of foreign language interaction when organizing a dialogue of cultures is significant. In methodological terms, a carefully constructed teaching strategy is required, embedded in the aspect of a linguistic and cultural approach for a better understanding of the mentality, way of life of the Chinese people, their culture and history.

In conclusion it is noted that the thematic content has been determined, the existing teaching experience on this issue has been systematized, and the main types of tasks in teaching the Chinese language to students in the linguistic and cultural aspect have been identified.
Artificial Intelligence as a Potential Catalyst to a More Equitable Cancer Care
Authors: Garcia-Saiso Sebastian , Marti Myrna , Pesce Karina , Luciani Silvana , Mujica Oscar , Hennis Anselm , D'Agostino Marcelo
Published: July 2024

As we enter the era of digital interdependence, artificial intelligence (AI) emerges as a key instrument to transform health care and address disparities and barriers in access to services. This viewpoint explores AI's potential to reduce inequalities in cancer care by improving diagnostic accuracy, optimizing resource allocation, and expanding access to medical care, especially in underserved communities. Despite persistent barriers, such as socioeconomic and geographical disparities, AI can significantly improve health care delivery. Key applications include AI-driven health equity monitoring, predictive analytics, mental health support, and personalized medicine. This viewpoint highlights the need for inclusive development practices and ethical considerations to ensure diverse data representation and equitable access. Emphasizing the role of AI in cancer care, especially in low- and middle-income countries, we underscore the importance of collaborative and multidisciplinary efforts to integrate AI effectively and ethically into health systems. This call to action highlights the need for further research on user experiences and the unique social, cultural, and political barriers to AI implementation in cancer care.
The Impact of Digital Technology on the Physical Health of Older Workers: Protocol for a Scoping Review
Authors: Spijker Jeroen J A , Barlın Hande , Grad Diana Alecsandra , Gu Yang , Klavina Aija , Korkmaz Yaylagul Nilufer , Kulla Gunilla , Orhun Eda , Ševčíková Anna , Unim Brigid , Tofan Cristina Maria
Published: July 2024

Background

Digital technologies have penetrated most workplaces. However, it is unclear how such digital technologies affect the physical health of older workers.

Objective

This scoping review aims to examine and summarize the evidence from scientific literature concerning the impact of digital technology on the physical health of older workers.

Methods

This scoping review will be conducted following recommendations outlined by Levac et al and will adhere to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews) guidelines for reporting. Peer-reviewed papers written in English will be searched in the following databases: MEDLINE, Cochrane, ProQuest, Web of Science, Scopus, APA PsycInfo, and ERIH PLUS. The web-based systematic review platform Covidence will be used to create a data extraction template. It will cover the following items: study and participant characteristics, health measures, digital tool characteristics and usage, and research findings. Following the Population, Concept, and Context (PCC) framework, our review will focus on studies involving older workers aged 50 years or older, any form of digital technology (including teleworking and the use of digital tools at work), and how digital technologies affect physical health (such as vision loss, musculoskeletal disorders, and migraines). Studies that focus only on mental health will be excluded. Study selection based on title and abstract screening (first stage), full-text review (second stage), and data extraction (third stage) will be performed by a group of researchers, whereby each paper will be reviewed by at least 2 people. Any conflict regarding the inclusion or exclusion of a study and the data extraction will be resolved by discussion between the researchers who evaluated the papers; a third researcher will be involved if consensus is not reached.

Results

A preliminary search of MEDLINE, Epistemonikos, Cochrane, PROSPERO, and JBI Evidence Synthesis was conducted, and no current or ongoing systematic reviews or scoping reviews on the topic were identified. The results of the study are expected in April 2025.

Conclusions

Our scoping review will seek to provide an overview of the available evidence and identify research gaps regarding the effect of digital technology and the use of digital tools in the work environment on the physical health of older workers.

International Registered Report Identifier (IRRID)

PRR1-10.2196/59900
Connecting Female Entertainment Workers in Cambodia to Health Care Services Using mHealth: Economic Evaluation of Mobile Link (Preprint)
Authors: Avanceña Anton L V , Brody Carinne , Chhoun Pheak , Tuot Sovannary , Yi Siyan
Published: July 2024

BACKGROUND

Mobile Link is a mobile phone–based intervention to increase access to, and use of, health care services among female entertainment workers in Cambodia who face higher risks for specific diseases and gender-based violence. A multisite randomized controlled trial showed that Mobile Link connected female entertainment workers with outreach workers for information and escorted referrals after 6 months but did not lead to statistically significant improvements in HIV and sexually transmitted infection testing, contraceptive use, and condom use.

OBJECTIVE

This study aims to conduct a 3-part economic evaluation of Mobile Link to understand its costs, value, and affordability.

METHODS

We conducted cost, cost-effectiveness, and budget impact analyses of Mobile Link using cost and outcomes data from the Mobile Link trial and other sources. For the cost analysis, we estimated the total, per-person, and incremental costs of Mobile Link compared with usual care. Using probabilistic decision-analytic models, we estimated the 1-year cost-effectiveness of Mobile Link from payer and combined payer and patient perspectives by converting selected primary and secondary outcomes from the trial to disability-adjusted life years (DALYs) averted. Finally, we estimated the financial costs of scaling up Mobile Link’s messaging and outreach services to 70% of female entertainment workers in 5 years.

RESULTS

The incremental costs of Mobile Link were US $199 from a payer perspective and US $195 per person from a combined payer and patient perspective. With an average of 0.018 (95% predicted interval –0.088 to 0.126) DALYs averted, Mobile Link’s cost-effectiveness was US $10,955 per DALY from a payer perspective (US $10,755 per DALY averted from a payer and patient perspective). The costs of Mobile Link would have to decrease by 85%, or its effectiveness would have to be 5.56 times higher, for the intervention to meet the upper limit of recommended cost-effectiveness thresholds in Cambodia (US $1671 per DALY averted). The 5-year cost of scaling Mobile Link to 34,790 female entertainment workers was estimated at US $1.64 million or US $46 per person per year.

CONCLUSIONS

This study provided a comprehensive economic evaluation of Mobile Link. We found that Mobile Link is not likely to be cost-effective unless its costs decrease or its effectiveness increases. Scaling up Mobile Link to more female entertainment workers is estimated to cost less than the costs of the trial. Given the importance of linking female entertainment workers to essential services, future research should focus on enhancing the effectiveness of Mobile Link or developing new mobile health interventions for this population.

CLINICALTRIAL

ClinicalTrials.gov NCT03117842; https://clinicaltrials.gov/study/NCT03117842
Assessing ChatGPT-4's Proficiency in English College Entrance Examinations Using Web Raschonline: A Comparative Study (Preprint)
Authors: Chow Julie Chi , Yeh Yu-Tsen , Chou Willy
Published: July 2024

BACKGROUND

ChatGPT, developed by OpenAI, is a state-of-the-art large language model that has demonstrated exceptional performance in various specialized applications. Despite the growing popularity and efficacy of artificial intelligence (AI), there is a lack of comprehensive studies assessing ChatGPT's competence, particularly ChatGPT-4V for images and text, on English tests for college entrance examinations using Rasch analysis.

OBJECTIVE

This study aims to (1) showcase the utility of the Rasch analysis website, RaschOnline, and (2) determine the grade achieved by ChatGPT-4V by evaluating its ability to handle questions involving both images and text, in comparison to a typical sample

METHODS

ChatGPT's capability was evaluated using 46 multiple-choice questions (MCQs) from the English tests conducted for Taiwan's college entrance examinations in 2024. Using a Rasch model, 300 simulated students with normal distributions were generated to compare with ChatGPT's responses. RaschOnline was used to create six visual presentations: item-difficulty plot, differential item functioning (DIF), item characteristic curve (ICC), performance plot, Wright map, and KIDMAP, to address the research objectives.

RESULTS

The findings revealed the following: (1) ChatGPT-4V's capacity was shown on the Wright Map, with 4.05 logits and a correct response rate of 0.98, resulting from the item 35 incorrectly answered during the visual identification of a comprehensive reading; (2) Item 35 was the most difficult (correct response rate=22%=67/301, with 1.59 logits on the item-difficulty plot); (3)An aberrant response with Zscore=-3.42 (<2.0, P<.05) on item 35 for ChatGPT-4V was shown on KIDMAP; (4) No DIF or capacity differences were observed between the two groups (P>.05 and P=.454, respectively), but significant in strata; (5) ChatGPT-4V uniquely classified as Grade A, standing out at the top on the performance plot when compared to other counterparts; (6) Item 35 displayed an good fit to the Rasch model with the infit mean square error (MNSQ) of 0.99.

CONCLUSIONS

Using RaschOnline, this study provides evidence that ChatGPT-4V possesses the ability to achieve a grade A when compared to a typical sample. After discussing the correct answer to item 35 with ChatGPT-4V, a 100% correct response rate was then achieved by either ChatGPT-4V or ChatGPT 4.0. ChatGPT-4V's excellent proficiency in answering MCQs with images and text from the English tests conducted in 2024 for Taiwan's college entrance examinations was evident.
A Comparison of Speech Biosignatures of Traumatic Brain Injury and Neurodegeneration (Preprint)
Authors: Rubaiat Rahmina , Templeton John Michael , Schneider Sandra L. , Silva Upeka De , Madanian Samaneh , Poellabauer Christian
Published: July 2024

BACKGROUND

Changes in various speech features have been linked to various neurological and mental health-related pathologies; these changes can often be detected years before a definitive clinical diagnosis. With the growing interest in using speech analysis for detecting a myriad of health conditions and the growing number of patients with multiple health problems, it will be increasingly important to demonstrate that speech analysis can differentiate between these conditions, to provide reliable and accurate diagnosis and assessment.

OBJECTIVE

Toward this end, this study takes a first step in this direction by examining the speech biosignatures of two common neurological conditions: (1) mild traumatic brain injuries (such as concussions) and (2) neurodegenerative diseases, particularly focusing on amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD).

METHODS

Further, this study utilizes two specific types of speech tests well-known to and frequently used by speech-language pathologists: a diadochokinetic test (“PaTaKa test”) and a sustained vowel test. This work investigates data from over 230 participants and examines 25 temporal and 12 spectral features of sound. We trained classification models using four popular machine learning algorithms including Support Vector Machine, Decision Tree, Random Forest, and Extreme Gradient Boosting (XGBoost) with three speech feature sets selected considering statistical significance based on the analysis of variance (ANOVA).

RESULTS

The results show that out of these 37 features, over 20 show statistical significance in differentiating between concussions, neurodegenerative diseases, and healthy controls. The paper further compares the performance of different classification models using these features. For the PaTaKa test, when the entire speech feature set was used, Decision Tree obtained the highest F1 score of 0.98 among the four classifiers. When the most significant speech feature set that has ANOVA p-values less than 0.05 was used, the highest F1-score (0.95) was obtained using XGBoost. A maximum F1-score of 0.93 was obtained with both Random Forest and XGBoost when the top statistically significant 5 features were used in model training. None of the classifiers could achieve an F1-score over 0.7 with speech features obtained through sustained vowel test.

CONCLUSIONS

This study demonstrated that the speech signatures of individuals with concussions, individuals with neurodegenerative conditions, and healthy controls differ in a way that allows us to identify unique patterns in speech associated with each condition, providing opportunities for the development of speech-based biomarkers for early detection and more accurate diagnosis. The findings of this study also indicate that it is feasible to use speech analysis to detect multiple different health conditions within the same person.
Strengthening the Backbone: Government-Academic Data Collaborations for Crisis Response (Preprint)
Authors: Yang Rick , Yang Alina
Published: July 2024

UNSTRUCTURED

This letter to the editor responds to a recent commentary highlighting the need for robust government-academic data infrastructures for public health crisis response. While there is agreement with the call for enhanced government-academic collaborations to improve data sharing during emergencies, an emphasis is placed on the need for deeper discussion on practical challenges and limitations. The letter underscores the critical role of data sharing in managing public health crises, noting the logistical and ethical challenges, particularly in maintaining data privacy and security. The COVID-19 pandemic showcased the difficulties in keeping sensitive health data confidential while ensuring timely research access. Thus, developing comprehensive data governance policies is highlighted as a crucial first step for successful collaborations. In addition, the integration of academic researchers into the public health response framework is supported but requires careful consideration of institutional inertia and bureaucratic resistance. Government entities follow rigid protocols, meanwhile academic institutions, accustomed to methodological rigor and peer-reviewed processes, may struggle with the urgent timelines required during crises. The letter calls for a realistic approach to maintaining sustained partnerships, addressing the need for ongoing funding, dedicated personnel, and continuous training. They stress the importance of actionable solutions for securing long-term funding and suggest leveraging academic expertise in data analysis while fostering bidirectional learning and capacity building. Finally, the letter advocates for standardized protocols for data collection and processing across sectors, investing in technologies that facilitate data harmonization and interoperability. The authors urge a nuanced analysis addressing data governance, institutional resistance, resource allocation, bidirectional learning, and data standardization to build sustainable government-academic collaborations for effective public health emergency responses.
Revealing the Economic Challenges on Adaptive Sacred Water Management in Balinese Community
Authors: Saraswaty Amrita Nugraheni
Published: July 2024

Abstrak
Studi ini membahas tantangan ekonomi yang dihadapi masyarakat lokal dalam mengelola sumber air, khususnya sumber air untuk kebutuhan ritual atau sakral, dengan fokus pada studi kasus di wilayah SARBAGITA, Bali. Penelitian ini menggunakan analisis kualitatif untuk menyelidiki interpretasi masyarakat Bali terhadap pengelolaan air adaptif pada sumber daya air suci. Dari analisis yang dilakukan, terlihat bahwa tantangan ekonomi pengelolaan sumber air suci masyarakat Bali dipengaruhi oleh ketidaksesuaian sistem tata kelola air dan kekuatan ekonomi industri pariwisata, yang keduanya saling berinteraksi sehingga berdampak pada menurunnya kualitas dan kuantitas sumber daya air, di sisi lain masyarakat Bali sangat bergantung pada air untuk praktik keagamaan. Pengambilan keputusan oleh perwakilan adat diperlukan karena pengelolaan adaptif diwujudukan dalam diri masyarakat adat melalui kearifan lokal. Memahami pengetahuan dan nilai-nilai air tradisional sangat penting untuk mengatasi tantangan ekonomi guna mencapai pengelolaan sumber daya air yang efektif.
Kata kunci: tantangan ekonomi; pengetahuan tradisional; pengelolaan adaptif; sumber air suci
Abstract
This study discusses the economic challenges that local communities face when managing water sources with ritual or sacred purposes, with a focus on the Balinese case study, especially in the SARBAGITA area. This study uses qualitative analysis to investigate the Balinese interpretation of adaptive water management of sacred water resources. According to the results of the analysis, the economic challenges of managing sacred water sources in the Balinese community are influenced by unsuitable governance systems and the economic power of the tourism industry, both of which interact to affect declining water resource quantity and quality. Meanwhile, the Balinese community relies heavily on water for religious practices. Decision-making by customary representatives is required because adaptive management is manifested in indigenous peoples through local wisdom. Understanding traditional water knowledge and values is critical for overcoming economic challenges and accomplishing effective water resource management.
Keywords: economic challenge; traditional knowledge; adaptive management; sacred water resource
Proactive Identification of Live Cyber Threats in IoT-Enhanced Security Systems
Authors: Kulkarni Dr. Sapna B
Published: July 2024

Abstract: A computer network may be impacted by malicious software, computer viruses, and other hostile attacks. A crucial element of network security is intrusion detection, which is an active defensive system. Traditional intrusion detection systems suffer from problems including poor accuracy, poor detection, a high rate of false positives, and an inability to handle novel forms of intrusions. To address these issues, we propose a deep learning-based novel method to detect cybersecurity vulnerabilities and breaches in cyber-physical systems. The proposed framework contrasts the unsupervised and deep learningbased discriminative approaches. We presents a generative adversarial network to detect cyber threats in IoT-driven IICs networks. The results demonstrate a performance increase in terms of accuracy, reliability, and efficiency in detecting all types of attacks. The output of well-known state-of-the-art DL classifiers achieved the highest true rate (TNR) and highest detection rate (HDR) when detecting the following attacks such as BruteForceXXS, BruteForceWEB, DoS_Hulk_Attack, and DOS_LOIC_HTTP_Attack on the three data sets namely NSL-KDD, KDDCup99, and UNSW-NB15 datasets. It also maintained the confidentiality and integrity of users’ and systems’ sensitive information during the training and testing phases
Model Pendidikan Kewarganegaraan Sebagai Pembelajaran Moral Dan Karakter
Authors: Nurdiansyah Edwin , Aulia Novemy Dhita
Published: July 2024

Citizenship education which is often identified with moral and character education is very interesting to study, especially regarding appropriate learning models to be applied in the learning process. This study aims to provide an argumentative description of civics education as a way of learning morals and character. This research was carried out using a qualitative approach through literature studies. Data analysis focused on data reduction, data display and drawing conclusions. The results of this study indicate that moral and character learning must be carried out by prioritizing critical thinking skills, one of which can be through Habermas' emancipatory questions, that is why civics education must be carried out with a dialogical approach through critical pedagogy so can make realize moral and character actions in accordance with which are expected.
The problem of locating the battle of 1223 between the Mongols and the Volga Bulgars
Authors: Stavitsky Vladimir V. ,   Penza State University
Published: July 2024

Research objectives: To clarify the localization and circumstances of the battle that took place in 1223 between the Mongols and the Volga Bulgars. Research materials: Data from the Complete History of Ibn al-Asir, Russian chronicles, archaeological materials of Zolotarevsky settlement are analyzed, hypotheses of Russian historians are considered: A.Kh. Khalikov, L.N. Gumilev, I.L. Izmailov and others. Research results and scientific novelty: The 800 years since the battle of Volga Bulgars with Mongols is celebrated this year. Direct information about the battle is contained only in the work of Ibn al-Asir. Geographical coordinates of the battle are absent; it is only recorded that it took place when the Mongols approached the city of Bulgar. A.Kh. Khalikov suggested that the battle took place in the Volga region, near Samarskaya Luka. L.N. Gumilev believed that the Mongols were defeated at the crossing of the Volga, but this point of view does not agree with the data provided by Ibn al-Asir. I.L. Izmailov came to the conclusion that the battle took place on the, Upper Sura in the vicinity of the Zolotarev settlement where a significant collection of elite Mongol armament was gathered. The settlement was on a trade way from Bulgar to Kiev. Therefore, if the Mongols went from the territory of the Don region, they could hardly pass it. However, according to Chinese and Old Russian sources, the main goal of the Mongols was to defeat the Cumans. In pursuit of them they had to go to Saksin and only from there turn to the north. In the message of Ibn al-Asir there is a figure of 4 thousand Mongol warriors. A number of historians believe that it refers only to the number of troops who retreated to Saksin, but more likely is the assumption that this is the number of those who died in the battle. In this connection, only the vanguard detachment pursuing the Polovtsians was defeated in the battle.
Medieval Settlement “Samar”: on the Issue of Analysis and Interpretation of Sources
Authors: Galimov Shamil Kh. ,   Samara Regional Tatar National-Cultural Autonomy
Published: July 2024

The purpose of the study: To analyze well-known materials and introduce published sources and works of researchers into a wide scientific circulation, indicating the possibility of the appearance of Samara in the Golden Horde era. Research materials: “Nogai affairs”. “Piskarevsky Chronicler”, the works of domestic and foreign researchers of the 19th century and the post-revolutionary period. Results and scientific novelty of the study: According to the current historiographical theory, the time and circumstances of the emergence of the town (fortress) of Samara are defined as being in 1586 and are associated with the construction of a new Russian fortress in the tract at the confluence of the Samara and Volga rivers on the southeastern borders of the Moscow state. In establishing and recognizing this fact by the main part of researchers (and especially in the practice of promoting historical knowledge), a certain mythologization of the event played an important role when, as is found in well-known historical documents, a settlement with the same name was founded in the middle of the 14th century in the area of the current city of Samara. In most scientific and popular scientific publications, sources that could contribute to a more comprehensive and objective disclosure of the topic are rejected without sufficient argumentation. Therefore, official historiography continues to adhere to the point of view that, firstly, the well-known maps of Pizigani in 1367 and Fra Mauro in 1459 incorrectly reflect the geography of Eastern Europe and, secondly, if the said settlement of Samar existed at that time, it cannot be considered a forerunner of the current city of Samara. Meanwhile, historical documents and a detailed analysis of the works of researchers of the 19th century with their complex use, at least, allow us to question these categorical statements and raise new questions about the events preceding the inclusion in the 16th century of the Middle Volga as part of the Russian state.
STRATEGY TO IMPROVE THE QUALITY OF ISLAMIC SERVICES TO CUSTOMERS AT INDONESIA SHARIA BANK (BSI) IN JAMBI
Authors: Kurnia Arya Aji , Rafidah
Published: July 2024

This study aims to find out how the strategy is to improve the quality of Islamic services contained in Indonesia Sharia Bank for its customers during the Covid-19 period in Jambi. The research method was field research using qualitative in nature, data collection used three techniques, namely observation, interviews, and documentation and was carried out on December 13, 2021 at Indonesia Sharia Bank, Jambi. The results of the research strategy to improve the quality of Islamic services to customers of Indonesia Sharia Bank in Jambi and in accordance with the concept of Ultimate Service as Business Acceleration have been running optimally in accordance with the 6 dimensions of service quality described by Othman and Owen known as the CARTER method, (Compliance, Assurance, Responsiveness, Tangible, Empathy and Reliability). Principles of Islamic law do not cheat and always provide financial solutions.
National clinical practise guidelines - prevention and treatment of uncomplicated urinary tract infections
Authors: Dimkovic Nada , Lezaic Visnja
Published: July 2024

Uncomplicated urinary tract infections occur in persons with morphologically and functionally normal lower and upper urinary tract, normal kidney function, and a competent immune system. They are one of the leading reasons of antibiotics misuse. There is much controversy regarding the screening, diagnosis, and treatment of urinary tract infection. This article summarizes the most common urinary tract infections and those that cause the most doubts in daily clinical practice. The goal is to stimulate physicians in using the latest recommendations of the national guidelines that may help them in daily clinical practice.
Teacher professional learning community and interdisciplinary collaborative teaching path under the informationization basic education model
Authors: Li Gen , Jamil Hazri
Published: July 2024

The construction of a learning community cannot be separated from the participation of information technology. The current teacher learning community has problems of low interaction efficiency and insufficient enthusiasm for group cooperative teaching. This study adopts the Latent Dirichlet allocation method to process text data generated by teacher interaction from the evolution of knowledge topics in the learning community network space. At the same time, the interaction data of the network commu-nity learning space is used to extract the interaction characteristics between teachers, and a collaborative teaching group is formed using the K-means clustering algorithm. This study verifies the management effect of Latent Dirichlet allocation and K-means algorithm in learning community space through experiments. The experiment showed that the Latent Dirichlet allocation algorithm had the highest F1 value at a K value of 12, which is 0.88. It collaborated with the filtering algorithm on the overall F1 value. At the same time, there were a total of 4 samples with incorrect judgments in Latent Dirichlet allocation, with an accuracy of 86.7%, which is higher than other algorithm models. The results indicate that the proposed Latent Dirichlet allocation combined with K-means algorithm has superior performance in the management of teacher professional learning communities, and can effectively improve the service level of teacher work.
Waste Management Concerns and Sustainable Urban Environment: Lessons from the Location of the Rumueme Ultramodern Abattoir
Authors: I Brown
Published: July 2024

Location and waste management are crucial issues in the development of abattoirs in an urban environment. The study explored the locational and waste management implications of Rumueme Abattoir to improve sustainability within the urban environment of Port Harcourt City. The study adopted a quantitative approach using a descriptive research design. An impact zone of a 1.5km radius was delineated in the area of study using purposive and simple random sampling techniques to select studied communities and respondents of the study. Taro Yamane formula was employed to determine the sample size for the study at a 5% precision level. A total of 396 respondents were sampled to obtain relevant information for the study. The study found that there are both positive and negative implications for the location of the abattoir in the community. The positive implications highlighted were the growth of the local economy, employment opportunities, proper waste disposal, use of renewable energy, electricity and water supply and social networking. The negative implications were an increase in rents, pollution levels, security challenges, dust particles, indiscriminate dumping of waste, loss of biodiversity and deforestation if the positive implications are not handled properly. The study further revealed that the extent of the waste management methods employed implications positively were adjudged beneficial while the negative implications if the methods employed are not used will have very high negative implications. However, to address these findings, the study recommended that infrastructure and services such as electricity and water supply should be given priority consideration in the environment of the facility, and all stakeholders including government, residents and communities should be involved in the operational process for proper implementation of regulations and standards, a special purpose vehicle should be provided monitor activities within the environment and wastes should be treated before final disposal.
Pengaruh Ketersediaan Amenitas pada Wisata Malam terhadap Kenyamanan Aksesibilitas Masyarakat Kampung Prawirotaman
Authors: Kuncoro Devanda Dana , Pramitasari Diananta
Published: July 2024

Kampung Prawirotaman merupakan salah satu kampung yang dijadikan destinasi wisata di Kota Yogyakarta. Dahulunya Kampung Prawirotaman dikenal sebagai kampung batik. Seiring berjalannya waktu kini dikenal sebagai kampung turis. Berkembangnya kegiatan pariwisata yang berlangsung di Kampung Prawirotaman mengakibatkan meningkatnya pembangunan kegiatan wisata yang semakin didominasi oleh kegiatan wisata malam seperti café, restoran, dan bar yang berada pada koridor jalan sekunder. Pembangunan wisata malam yang tidak diimbangi dengan ketersediaan amenitas menimbulkan beberapa konflik antara pengusaha dan masyarakat setempat. Penelitian ini bertujuan mengetahui kenyamanan masyarakat dari aspek aksesibilitas setelah adanya amenitas khususnya area parkir pada setiap tempat wisata malam yang ada di Kampung Prawirotaman. Metode yang digunakan dalam penelitian ini adalah metode kualitatif eksploratif. Analisis hasil data hasil dari pengisian kuesioner oleh 51 responden menggunakan metode analisis deskriptif. Hasil dari penelitian ini menyimpulkan bahwa hanya 2 dari 16 wisata malam yang memiliki amenitas area parkir memadai, sehingga titik-titik wisata malam masih menimbulkan  ketidaknyamanan dalam aspek aksesibilitas bagi penduduk lokal, yaitu pada indikator kepadatan lalu lintas. Sedangkan pada indikator penggunaan ruas untuk pejalan kaki mayoritas responden masih merasa nyaman. Sebagai tambahan, adanya wisata malam hingga larut malam membuat masyarakat lokal merasa aman. Hal ini disebabkan karena terdapat banyak orang yang beraktivitas pada malam hari.
Reconciliation of Spatial and Functional Transformation - Lokananta and Rumah Atsiri Adaptive Reuse
Authors: Saika Raisa Maranta , Maheswari Kirana Zhafirah , Agustiananda Putu Ayu Pramanasari , Sinaga Bryan Putra Parsada
Published: July 2024

Buildings are constructed for a variety of different purposes according to the human activities within them. However, with the changing times, the function of buildings can become out of line with current needs. As a result, some buildings are abandoned, becoming neglected, or even damaged. Adaptive reuse can be one of the strategies to 'revive' abandoned buildings. This strategy is an important process in maintaining historic buildings because it can maintain, repair, replace, change, add to dismantle building elements while still avoiding damage to parts that have important value. This process is influenced by several factors, including the cultural integrity and architectural integrity of the building. Therefore, the purpose of this research is to understand the concept of adaptive reuse, in terms of spatial and functional adjustments based on the cultural and architectural integrity of a building. In this research, two museums, namely Lokananta and Rumah Atsiri became case studies. The research method used is the qualitative comparative method, which is to collect data based on existing data and direct observation such as documentation, interviews, and questionnaires. The results of the data from these two buildings were then analyzed by comparing the buildings before and after adaptive reuse to determine the effect of cultural and architectural integrity on changes in space and building functions.
Identifikasi Pencahayan Alami untuk Mendukung Aktivitas Pengguna pada Vila Wukirsawit Di Jatiyoso
Authors: Saputra Arif Enggal , Nugrahaini Fadhilla Tri
Published: July 2024

Salah satu aspek perancangan bangunan yang perlu dipertimbangkan adalah konsep konservasi energi pada sistem pencahayaan. Sistem pencahayaan alami yang optimal dapat memberikan kenyamanan visual dan mereduksi hingga 20% energi listrik akibat penggunaan cahaya buatan. Standar Intensitas Cahaya berdasarkan SNI 03-2396 2001 memiliki rentang antara 120-250 lux. Bukaan pada ruangan berpengaruh terhadap distribusi cahaya pada ruangan. Semakin besar dimensi bukaan maka distribusi cahaya semakin besar. Vila Wukirsawit terletak di Jatiyoso, Karanganyar dengan luas bangunan 253,8 m2 dan memiliki 8 ruang dengan bukaan yang variatif, pemilihan vila wukirsawit dikarenakan menurut penulis belum banyak penelitian pencahayaan alami pada dataran tinggi sehingga penelitian ini mampu memberikan inovasi baru untuk penelitian pencahayaan alami. Penelitian bertujuan untuk mengukur intensitas cahaya pada Vila Wukrisawit dan memberikan alternatif agar intensitas pencahayaan pada ruangan lebih optimal. Identifikasi dilakukan pada 8 titik ruang menggunakan Luxmeter yang berlangsung selama 3 hari.  Hasil penelitian menunjukkan bahwa 7 dari 8 ruang dengan intensitas cahaya melampaui standar yang disebabkan oleh dimensi bukaan yang terlalu besar dan beberapa ruang berhadapan langsung dengan arah lintasan matahari sehingga terdistribusi cahaya berlebih.  Alternatif berupa pengurangan dimensi bukaan menunjukkan penurunan intensitas cahaya hingga 56% pada 3 ruang dan dilakukan relayout pada 4 ruang dengan intensitas cahaya berlebih. Agar terciptanya ruang dengan intensitas cahaya yang optimal, diperlukan alternatif lain berupa penambahan shading pada bagian atas bukaan hingga penggunaan material yang sesuai dengan kondisi pencahayaan ruangan.
Bioinformatics Techniques for Developing Molecular Detection Methods for the HIV-1 Gag Gene
Authors: Asryadin Asryadin , Yuniati Nilasari Indah , Khasanah Nur Aini Hidayah , Aqwam Adhi , Khairunnisa Rizka , Endang Hetti Koes , Nurhidayah Jumratul , Wahyono Daniel Djoko , Yuniaty Alice
Published: July 2024

The HIV-1 Gag gene, which plays an essential role in HIV replication, can be detected accurately using qRT-PCR. The quality of qRTPCR analysis is determined by the primers and probes used for DNA amplification. This research aims to use bioinformatics techniques to design primer pair sequences and qRT-PCR probes for HIV detection using the HIV-1 Gag gene. HIV-1 Gag gene sequences were obtained from HIV-1 isolates and serotypes, downloaded from the National Center for Biotechnology Information (NCBI) GenPeptd nucleotide database. Sequences were then examined using the ClustalW algorithm of the Bioedit sequence alignment editor version 7.2.5.0. through gene alignment using multiple sequence alignment (MSA) with conserved regions. The primer pair sequences of the Gag-HIV 1 gene were obtained, namely, forward 5'-CAGTACAATGTGCTTCCACAGGG-3 and reverse 3'-CGGGATAGAGATTCAGTCTAGG-5' with the probe sequence 5'-GGATCACCAGCAATATTTCAGGGAACG-3'. The primer sequence has a length of 23 bases (forward), 22 bases (reverse), GC content of 52% (reverse), 50% (forward), and the same forward and reverse melting temperature (Tm) of 66°C. The probe sequence is 27 bases long, with a GC content of 48% and a Tm of 67.3°C. No hairpin loops and dimers were formed in the primer pair or probe, and the gag gene had 100% homology with HIV-1. It was concluded that the primer and probe pair sequences met the requirements and could be used to amplify the HIV-1 Gag gene using qRT-PCR.
THE ROLE OF INDONESIAN YOUTH IN PROMOTING ECOTOURISM POLICY: A POLITICAL SOCIOLOGY REVIEW
Authors: Pikardo Ronaldo , Zhan Fuzy Firda , Ruspandi Alvein , Asy’ari Asy’ari
Published: July 2024

The ecotourism development strategy is not only the responsibility of the central and regional governments but also all levels of society, including the younger generation. This research aims to examine the role of Indonesian youth in pushing ecotourism policy from a political sociology perspective. Through qualitative descriptive methods with data obtained from literature studies, this research found that youth play a role in destination management, promotion via social media, and support for ecotourism policies. Youth also play a social control role and support participation in policy meetings. Apart from that, it is also known that social and political factors influence the role of youth in ecotourism development, namely social factors and political factors. However, challenges such as lack of promotion and participation of local communities need to be addressed. Therefore, collaborative efforts are required between youth, government, and society to overcome these obstacles and maximize the potential of ecotourism in Indonesia.