bluuebunny/crossref_metadata_2025 huggingface dataset:
m6A reader IGF2BP1 accelerates apoptosis of high glucose-induced vascular endothelial cells in a m6A-HMGB1 dependent manner
Authors: Liang Anru , Liu Jianyu , Wei Yanlin , Liao Yuan , Wu Fangxiao , Ruan Jiang , Li Junjun
Published: March 2023

Emerging evidence indicates that N6-methyladenosine (m6A) plays a critical role in vascular biological characteristic. In diabetes mellitus pathophysiology, high glucose (HG)-induced vascular endothelial dysfunction is associated with diabetes vascular complications. Nevertheless, the underlying mechanism of high glucose (HG)-related m6A regulation on vascular endothelial cells is still unclear. Results indicated that m6A reader insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) was up-regulated in HG-treated human umbilical vascular endothelium cells (HUVECs) comparing to normal group. Functionally, results indicated that IGF2BP1 knockdown recovered the proliferation of HUVECs inhibited by HG-administration. Besides, IGF2BP1 knockdown reduced the apoptosis induced by HG-administration. Mechanistically, IGF2BP1 interacted with HMGB1 mRNA and stabilized its expression of m6A-modified RNA. Therefore, these findings provided compelling evidence demonstrating that m6A reader IGF2BP1 contributes to the proliferation and apoptosis of vascular endothelial cells in hyperglycaemia, serving as a target for development of diabetic angiopathy therapeutics.
Some Thoughts on the Teaching Reform of Tourism and Hotel Management Specialty
Authors: Peifeng Zhu
Published: March 2023

Tourism and hotel management are two disciplines that have seen significant growth over the years. With the rise in the tourism industry and an increased demand for hospitality services, the need for qualified professionals in the field has also increased. However, the traditional teaching methods used in these disciplines have been challenged in recent times. The aim of this thesis is to analyze the current state of tourism and hotel management education, identify the limitations of the traditional teaching methods and suggest possible solutions for teaching reform. This thesis argues that tourism and hotel management education need to incorporate more practical and experiential learning methods to better prepare students for the real world. This can be achieved through partnerships with industry stakeholders, more hands-on learning opportunities, and the integration of technology in the curriculum. By implementing these reforms, we can ensure that future graduates are better equipped to meet the evolving demands of the tourism and hospitality industry.
Abordagens JIT e MRP com aplicações complementares no ambiente de produção
Authors: Pacheco Diego Júlio , Maciel Felipe Ramos , Pacheco Livia Júlio
Published: March 2023

A gestão produtiva possui grande relevo para a eficiência do uso de recursos assim como na eficácia do atendimento ao cliente. No presente trabalho, são analisadas as características e as práticas que envolvem dois dos principais sistemas de planejamento e controle da produção: Manufacturing Resource Planning (MRP) e Just in Time (JIT). Comumente, as empresas empregam uma das abordagens para gerenciar o processo produtivo, no entanto se verificou que as diversas vantagens e desvantagens apresentadas por cada mecanismo podem interagir positivamente no mesmo ambiente organizacional e gerar benefícios significativos. Através de um levantamento realizado na literatura, o trabalho elenca seis abordagens não excludentes que demonstram como MRP e JIT podem coexistir e cooperar no sentido de reforçar seus pontos positivos e minimizar os efeitos negativos, proporcionando melhorias à atividade de administração da produção.
Geração de ideias para desenvolvimento de novos produtos: estudo de caso em uma indústria de papel
Authors: Wittmann Anderson Luiz , Merigo Adriana Terezinha Lorenzetti , Castilho Sandro , Angnes Juliane Sachser
Published: March 2023

A inovação contínua é chave para o progresso das organizações. Para tanto, neste estudo de caso, identificou-se quais são os fatores motivacionais para colaboradores de uma indústria de papel elaborarem novas ideias para o desenvolvimento de produtos. O processo metodológico para consecução do objetivo proposto deu-se por meio das técnicas de grupo focal e análise documental. Os resultados apontaram que os elementos não financeiros têm maior impacto na motivação dos funcionários, por meio do reconhecimento na organização e disponibilização de um ambiente adequado para a inovação de produtos, através da maior tolerância a riscos e disponibilização de recursos, como diretrizes, tempo e informações. Como forma de reconhecimento financeiro, identificaram-se fatores como valorização e qualificação dos profissionais, através de visitas a feiras, outras empresas e cursos de especialização com alto potencial para a motivação, especialmente para os funcionários que são intrinsecamente motivados para inovar.
Análise dos elementos estruturais físicos, pedagógicos e metodológicos de escolas ribeirinhas amazônicas
Authors: Souza Edney Costa , De Andrade Rafael Ademir Oliveira , Dos Santos Jean Carlo Silva , Da Silva Roxane Dias , De Menezes Elisangela Ferreira , Da Silva Rodrigo César Moreira , Martins Letícia Nunes Nascimento
Published: March 2023

A construção de usinas hidrelétricas nos leitos dos rios amazônicos tornou-se uma saída para o déficit energético no Brasil, porém para que fossem sanadas as deficiências energéticas algumas ações causaram impactos decorrentes de suas construções, com destaque para o remanejamento, comumente decorrente do alagamento que surge às margens dos rios onde populações tradicionais geralmente habitam. Sendo assim, este artigo busca analisar os elementos: estruturais físicos e pedagógicos metodológicos, utilizados pelos professores de escolas localizadas em comunidades ribeirinhas amazônicas atingidas pela construção de usinas hidrelétricas. Destacamos que o cenário educacional da Amazônia, não abrange apenas a mudança da estrutura física das escolas; implica, as estruturas pedagógicas e metodológicas desenvolvidas pelos professores. O estudo ainda busca contextualizar o cenário amazônico onde situam-se escolas ribeirinhas amazônicas que foram atingidas pela construção de usinas do Madeira, com isso, identificando os elementos estruturais pedagógicos e metodológicos relacionados a ambientes educacionais ribeirinhos. Vale salientar que a educação na Amazônia precisa de visibilidade, para que seja tratada de forma particular, dadas as suas singularidades, onde as maiores mudanças atingem a conjuntura humana, especialmente, o processo educativo.
Programa Nota MT: reflexos da cidadania fiscal sob a ótica da teoria institucional
Authors: Da Silva Tania Favalessa , Dos Santos Josiane Silva Costa , Lira Thais Alves , Kruly Laís Beatriz , Musial Nayane Thais Krespi
Published: March 2023

A utilização de programas que facilitam e promovem a divulgação de informações vem transformando o relacionamento entre governo e sociedade, ampliando a transparência e desburocratizando determinados procedimentos, como é o caso do Programa Nota MT. Este estudo buscou analisar os reflexos da cidadania fiscal fomentada pelo Programa Nota MT sob a ótica da Teoria Institucional. A pesquisa é descritiva, com abordagem quantitativa e, quanto ao procedimento, documental. A população é composta por todos os usuários cadastrados dos 141 municípios do Estado do Mato Grosso/Brasil. A análise compreendeu os anos de 2018 a 2021 e foi realizada com base em documentos como relatórios e boletins do aplicativo do Nota MT da Secretaria de Estado de Fazenda de Mato Grosso – SEFAZ/MT, esclarecimentos via e-mail e na legislação estadual. O tratamento estatístico dos dados obtidos foi realizado por meio do software SPSS 25, (Statistic Packpage Social Science). Dentre os principais resultados, identificou-se que não houve alteração estatística significativa das adesões ao Programa Nota MT, fato que pode ter relação com a pandemia de Covid-19, a qual influenciou o padrão de consumo da população e dificultou as campanhas de divulgação e sorteios. Todavia, comparando-se o início do ano de 2019 com o final de 2021, foi possível identificar a alteração do comportamento populacional ao observar aumento (52%) na quantidade de notas fiscais emitidas com CPF. Sob o prisma da Teoria Institucional, tal resultado indica que o processo de institucionalização do programa foi legitimado pela população no Estado do Mato Grosso.
O pragmatismo filosófico no conhecimento administrativo e na formação do administrador
Authors: Meller-da-Silva Fabrizio , Hernandes Cláudio Aurélio , Atamanczuk Mauricio João
Published: March 2023

Este ensaio tem por objetivo fazer uma análise epistemológica da Administração enquanto conjunto organizado de conhecimentos e da formação de administradores no contexto dessa Ciência. Assim, o trabalho está dividido em três partes: na primeira são apresentados argumentos acerca da teoria do conhecimento, na segunda, discute-se a trajetória da formação da Administração como área de conhecimento e na terceira aborda-se o ensino da Administração em cursos superiores de graduação considerando a proposição de posicionamento epistemológico do conhecimento administrativo e abordado uma ferramenta de ensino-aprendizagem: o método do caso, como um mecanismo do instrumento pragmatista. Deste modo, concluiu-se que o pragmatismo é a parte mais evidente e marcante da identidade desse campo de conhecimento. Embora haja críticas quanto à atuação de administradores e organizações no que concerne a práticas dissociadas do bem comum, esses se alinham com a proposta inicial da Administração: resolver problemas organizacionais práticos; apesar da tentativa de legitimação de novas abordagens em substituição à unidimensionalidade do mercado, como de Guerreiro Ramos, ainda os princípios pragmatistas se configuram como paradigma predominante na Ciência da Administração.
Impacto do CPC 06(r2) no preço das ações das empresas da Bovespa
Authors: Morais Maria Auxiliadora de Oliveira , Prado Alexsandro Gonçalves da Silva , Melo Lyana Glecia Gurgel , Da Silva Filho Roosevelt Bezerra , Martins Joana Darc Medeiros , Mota Renato Henrique Gurgel , de Moura Rosalynn Rebouças , Batista Júnior Antonio
Published: March 2023

Em 2017 o CPC editou a norma CPC 06 (R2), alinhada ao IFRS 16, com a finalidade de disciplinar a contabilização da operação do arrendamento mercantil e minimizar os efeitos provocados pela assimetria de informação contábil para os investidores. Portanto, o objetivo desse estudo é verificar se a aprovação do CPC 06 (R2) causou alguma alteração no valor das ações das empresas listadas na Bovespa. Trata-se de um estudo quantitativo, documental. Usou-se a técnica de estudo de eventos para analisar os retornos anormais dos ativos antes do evento e após o evento. A coleta de dados deu-se por meio do banco de dados Economatica. Os resultados mostraram que a publicação do CPC 06 (R2) não alterou o preço da ação das empresas com leasing operacional listadas na Bovespa.
Percepção dos contadores do médio oeste potiguar sobre ordem cronológica de pagamentos
Authors: Pereira Thalyta Paula Gomes , Da Silva Taynara Milene , Morais Maria Auxiliadora de Oliveira , De Moura Rosalynn Rebouças , Batista Júnior Antônio , Holanda Sandra de Souza Paiva , Do Nascimento José Shirley Pessoa , Sampaio Francisco Jean Carlos de Souza
Published: March 2023

A ordem cronológica de pagamentos é objeto de discussão desde a promulgação da Lei 8.666/93. No entanto, tornou-se necessária a sua regulamentação nos municípios jurisdicionados pelo Tribunal de Contas do RN, mediante a resolução 032/2016. De modo geral, esta normativa visa promover o equilíbrio no fluxo processual, bem como a garantia de um tratamento isonômico e impessoal para com os credores da Administração Pública. A partir disso, o estudo objetivou analisar a percepção dos contadores quanto à observância da ordem cronológica de pagamentos em municípios do Médio Oeste Potiguar. A pesquisa, se caracteriza como bibliográfica, estudo de campo e descritiva. A coleta de dados ocorreu por meio de questionário. Os resultados analisados revelam que os contadores em sua totalidade, deparam-se com limitações ao cumprir a ordem de pagamentos, em função do desiquilíbrio financeiro entre receitas e despesas, especificamente ao que se refere à ausência de planejamento nos municípios.
Matrizes curriculares de contabilidade nas universidades públicas Norte-Rio-Grandenses e o Currículo Mundial
Authors: de Sousa Raiane Oliveira , Da Silva Taynara Milene , Morais Maria Auxiliadora de Oliveira
Published: March 2023

Esta pesquisa teve como objetivo analisar e comparar o índice de conformidade das matrizes curriculares dos cursos de Ciências Contábeis disponibilizados nas universidades públicas norte-rio-grandenses, em comparação ao Currículo Mundial (CM), proposto pelo Intergovernmental working group on experts on international Standards on accounting and reporting (ISAR). A pesquisa se caracteriza como exploratória, documental, quanto à abordagem do problema se define como quali-quantitativa. os dados foram coletados nos portais eletrônicos dos cursos de graduação em Ciências Contábeis. O estudo se limitou em analisar apenas a nomenclatura de cada disciplinas não se estendendo aos conteúdos estudados. Os resultados mostraram que o nível de adequação entre as Universidades e Currículo Mundial apresentado pela ONU/UNCTAD/ISAR apresentam um baixo nível de adequação uma média de 22,72% de semelhança, e que isso pode influenciar de maneira negativa na formação acadêmica dos graduandos.
Contabilidade de custos: caso de uma indústria de temperos pauferrense
Authors: Morais Maria Auxiliadora de Oliveira , Prado Alexsandro Gonçalves da Silva , Melo Lyana Glecia Gurgel , Da Silva Filho Roosevelt Bezerra , Martins Joana Darc Medeiros , Mota Renato Henrique Gurgel , De Moura Rosalynn Rebouças , Batista Júnior Antonio
Published: March 2023

Com a evolução da contabilidade de custos a mesma tornou-se uma dessas ferramentas que contribui para a continuidade da empresa, pois fornece informações que tem por finalidade auxiliar na tomada de decisão. Considerando esses aspectos esse estudo teve como objetivo averiguar o uso da contabilidade de custos como ferramenta gerencial em uma Indústria de tempero da cidade de Pau dos Ferros/RN. Para o alcance do objetivo e desenvolvimento do trabalho foi realizada uma pesquisa de campo, onde foi aplicado um questionário formado de 12 questões fechadas e abertas a gerente financeira da Indústria de temperos da cidade de Pau dos Ferros/RN, a fim de conhecer se essa empresa usa a contabilidade de custos em sua gestão. Os resultados da pesquisa mostraram que a empresa estudada utiliza a contabilidade de custos e considera a mesma como uma ferramenta gerencial para auxiliar o gestor na tomada de decisão.
Perception of Medical Faculty about Online Teaching During COVID-19 Pandemic, Telangana, India: A Cross-sectional Study
Authors: Latha T Suma , Samala Niveditha , Sirikonda Primala
Published: March 2023

Introduction: The recent Coronavirus Disease (COVID) pandemic disturbed the medical education and training all over the world. Online education program is increasing rapidly, and the faculty need to be more competent for better student outcome. Faculty may be reluctant to embrace different forms of online teaching due to fear of change, concerns about reliability of technology, skepticism about outcome. Aim: To determine the perceptions of medical faculty about online teaching during pandemic and to identify the barriers faced by them. Materials and Methods: It was a cross sectional study , carried out at Osmania Medical College, Hyderabad, Telangana, India, between March 2021 to August 2021. The faculty involved in regular online teaching, were given pre- validated questionnaire consisting of 15 questions through Google forms . A Total of 80 faculty members responded to the questionnaire. The data was entered in Microsoft Excel and responses were recorded in terms of frequency and percentages. Results: Amongst the total 80 participants of the study, it was observed that 74 (92.5%) felt that technical training is needed prior to online teaching, 70 (87.5%) agree that absence of face to face interaction with students is a disadvantage of online teaching and 60 (75%) disagree that online teaching can replace traditional teaching in future. Conclusion: Online teaching demands more technical training for medical faculty. There is more apprehension and anxiety in faculty members towards technical issues and more time is required for online class preparation.
Hydrocele of Canal of Nuck In an Adult Female: A Case Report
Authors: Chitrambalam Tharun Ganapathy , George Nidhi Mariam , Selvamuthukumaran Sundeep , Reddy Lokesh , Christopher Pradeep Joshua
Published: March 2023

Hydrocele of the canal of Nuck is a rare abnormality, developing in the protruded part of the parietal peritoneum within the inguinal canal in a female. It is homologous to the processus vaginalis in males and obliterates from the seventh month of gestation to one year of age. Failure of obliteration, results in Nuck hydrocele or herniation of intra-abdominal contents through the patent Canal of Nuck. These are usually detected and repaired in young girls within the first five years of life. Reports of Canal of Nuck hydrocele in adults are sparse. Most of these patients are misdiagnosed on clinical examination and correctly diagnosed intraoperatively during surgery for suspected ‘inguinal hernia’. Here, this case is about a 25-year-old female, who presented with swelling in the right groin for one month. Computed Tomography of the abdomen showed features suggestive of a hydrocele within the Canal of Nuck. She underwent laparoscopic hydrocelectomy and laparoscopic hernia repair via the transabdominal preperitoneal approach. This case report highlights the novel approach of laparoscopic management of this rare case.
Role of DCE and DWI in Differentiating between Benign and Malignant Breast Masses using 3T MRI: A Cross-sectional Study
Authors: Pavithra A , Arasu P Sabari , Jayaprakash N , Kumar S Arun
Published: March 2023

Introduction: Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) imaging is the mainstay of breast MRI techniques in characterising breast masses. Diffusion-weighted Imaging (DWI) is an adjunct MRI technique to differentiate between benign and malignant breast masses. Aim: To evaluate the diagnostic efficacy of breast MRI by combining DCE-MRI and DWI to differentiate benign from malignant breast masses and compare it with histopathology. Materials and Methods: The present cross-sectional study was conducted in the Department of Radiology and Imaging, Bharat Scans private limited, Chennai, India, from July 2013 to April 2015. A total of 51 patients with suspicious breast masses detected by mammography and/or ultrasonography were evaluated by DCE-MRI and DWI using General Electric (GE) 3 Tesla Magnetic Resonance Imaging. The results were compared with histopathology. Sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Values (NPV) were calculated for DCE-MRI and for the combined method using DCE-MRI with DWI. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software version 17.0 and Open Epi software. A p-value <0.05 was considered statistically significant. Results: Out of the 51 masses, 26 were benign and 25 were malignant on histopathology. DCE-MRI showed a type I curve in 17 masses, type II curve in 11, and type III curve in 18, with a sensitivity of 88% and specificity of 73.08% in differentiating benign from malignant masses. In DWI, 26 masses showed diffusion restriction with a mean Apparent Diffusion Coefficient (ADC) value of 1.108×10-3 mm2/s and 25 masses showed the absence of diffusion restriction with a mean ADC value of 1.656x10-3 mm2/s. In the combined evaluation (DCE-MRI+DWI), 27 masses were classified as malignant and 24 masses were classified as benign with improved sensitivity of 96% and specificity of 88.46% as compared with DCE-MRI or DWI alone. Conclusion: Dynamic contrast-enhanced magnetic resonance imaging has high sensitivity in differentiating benign from malignant breast masses, but has low specificity. Multiparametric MRI combining DWI with DCE-MRI increases the sensitivity and specificity, hence improving the diagnostic efficacy for breast mass evaluation.
Use of TWIST Score and BAL Score in Diagnosing Testicular Torsion in Children with Acute Scrotum: A Retrospective Study
Authors: Joseph Liya
Published: March 2023

Introduction: Early diagnosis and management of Torsion Testis (TT) in children is challenging. To improve the reliability of diagnosis, various clinical scoring systems have been proposed. Testicular Workup for Ischaemia and Suspected Torsion (TWIST) score and Boettcher Alert (BAL) score have been used for the diagnosis of TT in children with acute scrotum. Aim: To find the utility of TWIST and BAL score for diagnosing testicular torsion in children with acute scrotum. Materials and Methods: This was a retrospective recordbased study that included medical records of children with acute scrotum who underwent surgery between January 2019 and December 2021 in a tertiary care hospital. A total of 112 patients were included in the study. TWIST and BAL scores were calculated, retrospectively. Univariate analysis of the clinical features were done using Chi-square test. Sensitivity, specificity, Positive Predicitive Value (PPV) and Negative Predicitive Value (NPV) for scoring systems were calculated. Results: There were 73 patients in TT group and 39 in Non Torsion Testis (NTT) group. The mean age was 4.5±2.98 years in torsion group and 5.2±2.2 years in non torsion group. Among the components of TWIST and BAL score, absent cremasteric reflex, hard testicle, high riding testis, nausea/vomiting and pain duration <24 hours were found to be statistically significant. PPV and specificity of TWIST score ≥5 were 98.15% and 97.44%, respectively whereas NPV and sensitivity of BAL score ≥2 group was 100%. Conclusion: TWIST and BAL scores are reliable bedside and easy to perform clinical diagnostic tools for TT. These scores can help in early detection and plan surgical intervention to reduce ischaemia time of TT.
Urinary Myiasis in a Child Caused by Psychoda Species- A Rare Case
Authors: Kumar M Ravish , Harshangi Sandeep , Prashant Parandekar
Published: March 2023

Human myiasis is infestation of human living tissue with dipterous larvae. Urinary myiasis is quite rare, because the fly has to bypass the clothing/reach the inaccesable site (genitals) to lay egg, larva has to hatch and migrate to urinary bladder. It may occur in immunocompromised individuals and in people who maintain poor personal hygiene. Authors hereby, present a case of 10-year-old female child with complaints of passing of small worm like structures in urine for one month. The structure of worm was examined macroscopically and microscopically, and was identified as larvae of Psychoda species. She was started with tablet ivermectin and passage of worms was stopped. The present study highlighted the importance of awareness of clinicians about urinary myiasis condition as well as its management. Maintenance of good personal hygiene is important in prevention of such infestation.
Measuring Female Leadership Competencies of SMEs
Authors: Aisyah Esy Nur , Prajawati Maretha Ika , Setiani .
Published: March 2023

Small and medium enterprises’ (SME) success, performance, and growth are highly dependent on the competence of entrepreneurs.  Competency theory is based on studying successful leaders by researching their behavior, attitudes, and skills into measurable aspects and looking for ways to bring them together to create individuals who demonstrate superior performance. Research related to competence is motivated by the aspiration to achieve excellent performance and business success. Female leadership competencies are performances of women’s competence in leading a business. This study aims to evaluate the validity and reliability of the instrument measuring Female Leadership Competencies based on the concept of Cong & Thu (2020). The dimensions used as a reference in measuring tools consist of Strategic Visions, Operations Management, Professional Knowledge, Hands-on Experience, and Relationship Building in running a business. The respondents of this study were 100 women entrepreneurs in Batu City; the sample size was determined using the Slovin technique. This instrument was prepared using a Likert scale with five scales and Confirmatory Factor Analysis (CFA) techniques. The analysis showed that the measurement of Female Leadership Competencies was valid and reliable, with a Cronbach alpha score of 0.894. However, from the 29 items compiled, six items still need to be completed.
Implementation of the Free Senior High School Policy in Ghana: Five Years on; Major Benefits and Challenges
Authors: Shamo Anteson Daniel
Published: March 2023

The main purpose of the study was to explore the inherent benefits and challenges regarding the implementation of the free Senior High School policy in Ghana and how it is affecting teaching and learning in Senior High Schools in the Effutu Municipality of the Central Region of Ghana. The target population for the study were leadership of school heads within the Effutu Municipality. A qualitative research approach and a case study design was employed. Purposive sampling technique was used to select five head teachers. Semi-structured interview guide was used to collect data for the study. Thematic analysis approach was used to analyse the data. It was discovered through the respondents’ comments that the policy is a very good initiative, has led to increase school population, reduced financial burden on parents and payment of intervention allowance to teachers. Findings also indicate that inadequate infrastructure, inadequate funding from government, unstable school calendar and increase in teachers’ workload were means by which implementation of the policy has affected teaching and learning. Therefore, the Ghana Education Service should consider this paper as means of reviewing and revising the free Senior High School policy five years after its implementation taking into consideration key findings and recommendations of the study. Government should consider cost sharing with parents to ease pressure on its revenue since the policy is taking a substantial part of government’s budgetary allocation to the Ministry of Education. In addition, the government should increase the intervention allowance for teachers and pay it regularly in order to motivate teachers likewise seeking financial support from international donor agencies and other local financial institutions to provide adequate infrastructure in all schools.
Effect of Varieties and Spacing on Growth and Yield of Green Gram (Vigna radiata L.)
Authors: Gavali Yuvraj D. , Jaiswal Vaishnavi , Ghatak Ruhidas , Gawali Kevin
Published: March 2023

Aim: This research was conducted to evaluate the effect of varieties and spacing on growth and yield of green gram (Vigna radiate L.)

Study Design: Split Plot Design.

Place and Duration of Study: The experiment was conducted during season of 2021 at G.H. Raisoni University Student Research Farm, Saikheda.

Methodology: The experiment consisted of three main treatments varieties Kopargaon (V1), Sindhu (NVL-605) (V2) and PDM-139 (Samrat) (V3) and four sub treatments spacing 30 cm x 10 cm (S1), 30 cm x 15 cm (S2),45 cm x 10 cm (S3) and 45 cm x 15 cm (S4). Number of branches per plant, leaves per plant, pods per plant, pod length, grains per pod, test weight, seed and stover yield per hectare, protein content.

Results: Number of branches per plant (8.60), leaves per plant (21.00), pods per plant (15.53), pod length (8.55 cm), grains per pod (9.80), test weight (37.66 g), seed (9.06q/ha) and stover yield (18.49 q/ha), protein content (22.78%)

Conclusion:  green gram variety PDM-139 (Samrat) sown spacing of 30 cm x 10 cm recorded significantly higher growth and yield parameters.
Composition of Bioactive Carotenoid, Flavonoid, and Terpene compounds in Selected Fruits: A Mini Review
Authors: Nimita Grandhi N. V. G. K. S. , Vikanksha . , Singh Jatinder
Published: March 2023

Bioactive substances are secondary metabolites that are produced by plants to protect their body; yet, such substances are able to control metabolic functions and have beneficial effects on the human body. Vitamins, minerals, phenolics, antioxidants,     flavonoids, carotenoids, and micronutrients and fiber appear to be responsible for beneficial health effects such as curing diabetics, cardiac ailments, etc. Fruit-extracted/isolated bioactive components are considered to have antioxidant, anti-inflammatory, antibacterial, cardioprotective, and neuroprotective activities, according to research data from a variety of in vitro and in vivo studies. As a result, fruits have the potential to be turned into medications and functional foods that may be used to avoid or alleviate a variety of chronic issues. The nutritional and phytochemical composition of fruits is determined by their maturation level, variety, environmental conditions, agricultural practices, and post-harvest handling and processing. This review aims to describe the importance of different fruits as a significant source of phytocompounds, which are being studied in clinical trials to create drugs for curing various human ailments, such as obesity, diabetes, cardiac, and cancer conditions. The vast and varied wealth of fruits may yet include undiscovered and extremely strong bioactive chemicals, which require more investigation.
Assessment of Growth Rate and Instability of Groundnut Production in Odisha, India: A Statistical Modelling Approach
Authors: Dash Abhiram , Kishan Madhuchhanda , Mishra S. N. , Bhol Nirakar
Published: March 2023

Oilseeds in Odisha has a major contribution in increasing the income of farmers which is due to their greater economic value. The important oilseed crops grown in Odisha are groundnut, mustard, sunflower, sesamum and castor. Groundnut shares 34% of total area under oilseeds in Odisha and 64% of total production of oilseeds in the state. The present makes an attempt   to explore the best fit model on area, productivity and production of groundnut in Odisha and use the selected best fit model to estimate the growth rate of the variables. The instability of area, productivity and production of groundnut in Odisha is also studied with help of coefficient of variation.

Data from 1970-71 to 2019-20 have been used to estimate the growth rate and instability by dividing the whole period of study in two periods - pre-liberalisation period (1970-71 to 1995-96) which is referred as period I and post-liberalisation (1996-97 to 2019-20) which is referred as period II. Models considered in the analysis are linear model, logarithmic model, quadratic model, compound model and power model. Durbin-Watson test, Shapiro-wilk’s test and park’s test are used for testing error assumption. By testing the significance of parametric coefficient, residual diagnostics and the model fit statistics, the best fit model for the variable have been selected. Using the best fit model, the growth rate of area, productivity and production of groundnut in Odisha has been estimated. The measure of instability of area, productivity and production of groundnut is given by Coefficient of Variation.

The study reveals that different models have been found to be the best fit for different variables in different periods. The study of growth rate using the best fit model reveals that area and production of groundnut decrease in post-liberalisation period than pre-liberalisation period. The growth rate of productivity of groundnut increases in post-liberalisation period as compared to pre-liberalisation period. The situation is reverse with respect to instability. The study comes with the conclusion that as compared to pre-liberalisation period, the productivity performance of groundnut in Odisha has enhanced in post-liberalisation period. The poor performance in area under groundnut results in poor performance in production of groundnut during post-liberalisation period as compared to pre-liberalisation period. The appropriate model building technique helps in depicting a proper scenario of groundnut production in the state of Odisha.
Comparative Study of Mathematical Model Applications on the Amount of N-P-K Fertilizer Absorbed to Meet the Best Yield Data of Paddy (Rice) Cultivation
Authors: Dash Jyotirmayee , Kuila Mamata
Published: March 2023

Soil-based test studying prevailing to so many crops in Vindhyan alluvial plains from 2001 to 2004 has shown result of production on special rice crop (IR-36) by testing leveraging on soil stoichiometric testing and recommended balanced fertilizers and organic matter amelioration by application for the niche area of impact to targeted yield of paddy crop. The results confirm that soil micro-flora and micro-organisms speed up aeration, drainage, and the best crumby structures, resulting in embryonic fertility and support for crop plants' profuse and vigorous growth through the best soil texture under various agro-climatological divisions in particular. Preliminary and secondary data are calculated after administration of research questionnaire, structure, queue, flow and research objectives, first hand data fulfilment through field tour and experimental block designs under study in paddy-based ecosystem of control and treatment blocks. Nutrients and fertilizers are required for specific accelerated productivity of paddy crop by using control and treatment with specific fertilisers, which is organized in the old mathematical model of [CF (%)] and [CS (%)] gradient.  Data in relation to studies of nutrient percentage recommended model development through incursion into stoichiometric trends, analysis, models, algorithms, principles/procedures and quantisation. Regression formulae support the experimental design blocks. Studies by experimental design of blocks replication and finding of experimentations on different mathematical models led to outcome of best efficient recommended fertilizers dose to enrich/replenish the gap of inadequate fertilizers to the paddy (rice) crop to touch our targeted yield of rice crops. Analytical   trends and comparison experimentation sheet led to the effort for how much quantity fertilizers are actually needed for paddy crop growth by applying mathematical quantization and qualitative. Under experimental controls, originality of this innovative findings, this research supports systems approach for simplicity, spirituality and sustainability. We have used different mathematical models and three methods and comparing it with traditional method to show the better result of yield data of paddy crop.
Knowledge and Perception of COVID-19 Infection among the Diabetes Mellitus Patients in Nigeria: A Cross-Sectional Survey
Authors: Olugbemide Orebowale A. , Alabi Adewumi O. , Emorinken Airenakho , Dic-Ijiewere Mercy O. , Adunbiola Patrick O. , Akhuemokhan Kennedy I. , Otaigbe Osahon I.
Published: March 2023

Aim: This study aimed to assess the knowledge of coronavirus disease 2019 (COVID-19) and the perception of care among diabetes mellitus patients during the COVID-19 pandemic.

Methods: This was a cross-sectional study among 173 diabetes mellitus patients over 12 weeks in the endocrinology outpatient clinic. An interviewer-administered questionnaire was used to acquire data on socio-demographic and clinical characteristics, as well as questions to assess COVID-19 knowledge and perception of care. The data acquired were analyzed using SPSS, and a p-value less than 0.05 was considered significant.

Results: A total of 173 diabetes mellitus patients participated in the study, and there were more females than males (59% vs. 41%). The participants' mean age was 55.8 ± 14.9 years. The mean knowledge score was 12.42 ± 6.01, and the majority (51.4%) of the participants had poor knowledge of COVID-19 while 11.0% had good knowledge of COVID-19. Higher levels of education and monthly income were significantly associated with higher mean knowledge scores (P-value < 0.001). Increasing monthly income was the only significant predictor of higher knowledge scores (P-value < 0.001).

Conclusion: The majority of diabetes mellitus patients had poor overall knowledge of COVID-19. It is therefore imperative that patients with diabetes mellitus are well informed as new trends in COVID-19 unfold.
The effects of pharmacomechanical thrombolysis treatment administered to patients with iliofemoral deep vein thrombus
Authors:   Erzincan Binali Yıldırım University Mengücek Gazi Training and Research Hospital, Department of Cardiovascular Surgery, Erzincan, Türkiye, Onk Oruc Alper
Published: March 2023

Aim: In this study, the mid-term results of the pharmacomechanical thrombolysis treatment administered in patients with iliofemoral acute-subacute (patients with symptoms less than 21 days old whose DVT was diagnosed with physical examination and duplex ultrasonography) deep vein thrombus (DVT) were investigated. The cases were evaluated in terms of disease-related quality of life, and the presence of post-thrombotic syndrome (PTS) which occurred in patients after previous DVT and treatment, and if present, its severity was determined. Material and Methods: Disease-related status of 40 patients (24 males, 16 females; mean age 44; age interval 20-80 years) treated due to iliofemoral acute-subacute DVT with interventional method between July 2013 and January 2017 were retrospectively analyzed two years after the interventional treatment. These patients were considered as mid-term patients. The patients were evaluated with VEINES-QOL/Sym quality of life scale and the Villalta scale. The occurrence and severity of PTS, the presence of venous ulcer, and the diameter difference between legs were evaluated. Results: No venous ulcer was present in our cases. In the evaluation made with Villalta scale, PTS was not observed in 20 out of 40 cases, mild PTS was found in 15, moderate PTS in 4, and severe PTS was observed in 1 case. Conclusion: We have concluded that pharmacomechanical thrombolysis treatment administered in well-selected patients reduced the severity of PTS and increased the quality of life associated with disease in DVT treatment.
Hybrid management of lower limb huge pseudoaneurysm with arteriovenous fistula presenting 8 years after gunshot injury
Authors:   Department of Cardiovascular Surgery, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, Turkey, Engin Mesut , Guvenc Orhan , Aydin Ufuk ,   Kalp ve Damar Cerrahisi Kliniği, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Bursa, Ata Yusuf ,   Kalp ve Damar Cerrahisi Kliniği, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Bursa
Published: March 2023

All over the world, except during the war period, firearm injuries are encountered in daily life at varying rates depending on the region and country. In addition, late-term vascular complications may occur in injuries with a less traumatic appearance. In this present case report, we aimed to evaluate the hybrid treatment of giant pseudoaneurysm and arteriovenous fistula (AVf) in the left superficial femoral artery (SFA), which developed in a patient who had a pellet shot on his left thigh eight years ago. Postsurgical management was straightforward; the patient received antibiotherapy with ampicillin and sulbactam acid for 7 days, acetylsalicylic acid 100mg per day, and anticoagulant treatment with low molecular weight heparin for 1 month. The patient was examined in the cardiovascular surgery polyclinic on the 5th day after discharge uneventfully. Although endovascular treatment methods are widely used today in the treatment of vascular injuries, surgery still maintains its importance. In some special patient groups, a combination of these two treatment methods may be preferred.
Early outcomes of mantis pharmacomechanical thrombectomy system combined with catheter-directed thrombolysis for treatment of acute iliofemoral deep vein thrombosis
Authors:   Department of Cardiovascular Surgery, Ankara City Hospital, Ankara, Turkey, Yiğit Görkem
Published: March 2023

Aim: The purpose of this research was to investigate the early outcomes of pharmacomechanical thrombectomy (PMT) with the Mantis device and adjunctive catheter-directed thrombolysis (CDT) for the treatment of acute iliofemoral deep vein thrombosis (IFDVT). Material and Methods: Twenty patients with symptomatic acute IFDVT were successfully treated with the Mantis rotational thrombectomy device and CDT, between August 2020 and March 2021. Patients' demographical, clinical and follow-up data were obtained and analysed retrospectively. Villalta and Pain Severity scores were utilized to assess the patients for the occurrence of post-thrombotic syndrome (PTS). Results: The procedural success rate was 100%. All cases presented early clinical improvement. No device related complications were encountered. Reocclusion was observed in 3 (15%) patients. Pre-procedural median pain score was 7 (range: 6–8) and 1 (range: 0–7) at 12-month following thrombectomy (P < .001). Pre-procedural median Villalta score was 7 (range: 3–11) and 1 (range: 0–13) at 12-month following thrombectomy (P<.001). At 12-month follow-up, no PTS was reported in 15 (75%) patients, mild PTS was reported in 2 (10%) patients, moderate PTS was reported in 2 (10%) patients and no severe PTS was observed. Conclusion: The Mantis PMT system with CDT seems to be an efficient treatment approach for acute IFDVT with encouraging early results.
AI-Generated Medical Advice—GPT and Beyond
Authors: Haupt Claudia E. , Marks Mason
Published: March 2023

This Viewpoint describes medical applications of generative pretrained transformers (GPTs) and related artificial intelligence (AI) technologies and considers whether new forms of regulation are necessary to minimize safety and legal risks to patients and clinicians.
Brugada Pattern, Tall Peaked T Waves, Absence of P Waves, and Broad QRS Complexes
Authors: Zhuang Ziming , Lin Yangyi
Published: March 2023

This case report presents the electrocardiogram findings of a patient in their 70s with chest tightness and shortness of breath for 5 hours and loss of consciousness for 10 minutes.
Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock
Authors: Bosch Nicholas A. , Teja Bijan , Law Anica C. , Pang Brandon , Jafarzadeh S. Reza , Walkey Allan J.
Published: March 2023

Importance

Patients with septic shock may benefit from the initiation of corticosteroids. However, the comparative effectiveness of the 2 most studied corticosteroid regimens (hydrocortisone with fludrocortisone vs hydrocortisone alone) is unclear.

Objective

To compare the effectiveness of adding fludrocortisone to hydrocortisone vs hydrocortisone alone among patients with septic shock using target trial emulation.

Design, Setting, and Participants

This retrospective cohort study from 2016 to 2020 used the enhanced claims-based Premier Healthcare Database, which included approximately 25% of US hospitalizations. Participants were adult patients hospitalized with septic shock and receiving norepinephrine who began hydrocortisone treatment. Data analysis was performed from May 2022 to December 2022.

Exposure

Addition of fludrocortisone on the same calendar day that hydrocortisone treatment was initiated vs use of hydrocortisone alone.

Main Outcome and Measures

Composite of hospital death or discharge to hospice. Adjusted risk differences were calculated using doubly robust targeted maximum likelihood estimation.

Results

Analyses included 88 275 patients, 2280 who began treatment with hydrocortisone-fludrocortisone (median [IQR] age, 64 [54-73] years; 1041 female; 1239 male) and 85 995 (median [IQR] age, 67 [57-76] years; 42 136 female; 43 859 male) who began treatment with hydrocortisone alone. The primary composite outcome of death in hospital or discharge to hospice occurred among 1076 (47.2%) patients treated with hydrocortisone-fludrocortisone vs 43 669 (50.8%) treated with hydrocortisone alone (adjusted absolute risk difference, −3.7%; 95% CI, −4.2% to −3.1%; P < .001).

Conclusions and Relevance

In this comparative effectiveness cohort study among adult patients with septic shock who began hydrocortisone treatment, the addition of fludrocortisone was superior to hydrocortisone alone.
Intensity of Lipid-Lowering Therapy Among Patients With Polyvascular Disease
Authors: Peterson Benjamin E. , Bhatt Deepak L. , Ballantyne Christie M. , de Lemos James A. , Rosenson Robert S. , Kosiborod Mikhail N. , Cannon Christopher P. ,   GOULD Investigators
Published: March 2023

This cohort study assesses patterns in treatment of low-density lipoprotein cholesterol using lipid-lowering therapy among patients with and without polyvascular disease.
Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids
Authors: Li Hongyu , Gao Lixiong , Ye Zi , Du Jinlin , Li Wen , Liang Liqing , Zeng Quan , Xi Jiafei , Yue Wen , Li Zhaohui
Published: March 2023

Prenatal alcohol exposure‐induced fetal alcohol syndrome (FAS) can lead to serious maldevelopment in many organ systems, including the eyes. In the present study, the effects of alcohol exposure on early development of the human retina and the therapeutic effects of resveratrol on alcohol‐induced neural retinal damage were observed for the first time in an in vitro retinal organoid model. We report that the number of proliferating and apoptotic cells decreased and increased, respectively, following ethanol treatment. In addition, the number of PAX6+ cells and migrating TUJ1+ cells decreased after ethanol exposure. However, pretreatment with resveratrol prevented all of these negative effects. Using RNA sequencing and immunofluorescence, we identified activation of the PI3K‐AKT signalling pathway as the possible mechanism through which resveratrol protects the retina from alcohol‐induced damage. These results suggest that while ethanol exposure can restrict the growth of the human retina and impede the development of specific retinal cells, pretreatment with resveratrol may be a feasible method for preventing these effects.
Study on the relationship between the seated area features and floor plan compositions of open reading spaces in public libraries in Japan
Authors: Kojima Yuki , Komatsu Hisashi
Published: March 2023

This study aimed to clarify the relationship between the seated area features and floor plan compositions of open reading spaces found in 55 Japanese public libraries completed since 2000. These elements were approached from the viewpoints of floor plan forms, bookshelf area arrangement, seated areas, and seating arrangements in seated areas. As the result of the statistical analyses of 792 seated areas—based on the nature of users' coexistence with the sociopetal, sociofugal, and side‐by‐side viewpoints—eight types of seating arrangement in seated areas and the relationship between seating arrangement types and floor plan types were found.