bluuebunny/crossref_metadata_2025 huggingface dataset:
Translocator protein agonist Ro5-4864 alleviates neuropathic pain and promotes remyelination in the sciatic nerve
Authors: Ma Bingjie , Liu Xiaoming , Huang Xuehua , Ji Yun , Jin Tian , Ma Ke
Published: December 2017

Our previous study reported the translocator protein to play a critical role in neuropathic pain and the possible mechanisms in the spinal cord. However, its mechanism in the peripheral nervous system is poorly understood. This study was undertaken to explore the distribution of translocator protein in the dorsal root ganglion and the possible mechanisms in peripheral nervous system in a rat model of spared nerve injury. Our results showed that translocator protein was activated in dorsal root ganglion after spared nerve injury. The translocator protein signals were primarily colocalized with neurons in dorsal root ganglion. A single intrathecal (i.t.) injection of translocator protein agonist (7-chloro-5–4-chlorophenyl)-1,3-dihydro-1-methyl-2-H-1,4-benzodiaze-pine-2) (Ro5-4864) exerted remarkable analgesic effect compared with the spared nerve injury group ( P < 0.01). After i.t. administration of 2 µg Ro5-4864 on day 3, the expression of translocator protein in ipsilateral dorsal root ganglion was significantly increased on day 7( P < 0.01) but decreased on day 14 ( P < 0.05) compared with the same point in time in the control group. The duration of translocator protein activation in dorsal root ganglion was remarkably shortened. Ro5-4864 also inhibited the activation of phospho-extracellular signal-regulated kinase 1(p-ERK1) ( P < 0.01), p-ERK2 (D7: P < 0.01, D14: P < 0.05), and brain-derived neurotrophic factor ( P < 0.05) in dorsal root ganglion. Meanwhile, i.t. administration of 2 µg Ro5-4864 on day 3 further accelerated the expression of myelin protein zero(P0) and peripheral myelin protein 22 (PMP22). Our results suggested Ro5-4864 could alleviate neuropathic pain and attenuate p-ERK and brain-derived neurotrophic factor activation in dorsal root ganglion. Furthermore, Ro5-4864 stimulated the expression of myelin regeneration proteins which may also be an important factor against neuropathic pain development. Translocator protein may present a novel target for the treatment of neuropathic pain both in the central and peripheral nervous systems.
The ATTEND trial: An alternative explanation with implications for future recovery and rehabilitation clinical trials
Authors: Winstein Carolee
Published: December 2017

Over the past decade, ATTEND is one of only a handful of moderate to large-scale nonpharmacologic stroke recovery trials with a focus on rehabilitation. While unique in some respects, its test of superiority for the experimental intervention returned negative/neutral results, with no differences in outcome between the experimental intervention and an appropriate control group – a result not uncommon to the majority of moderate to large stroke rehabilitation intervention trials (i.e. six out of eight conducted in the past decade). The authors offer a number of potential explanations for the negative outcome, all of which have merit. We choose not to dwell on these possibilities, but rather offer a radically different explanation, one which has implications for future rehabilitation clinical trials. Our premise is that the process of neurorehabilitation is complex and multifaceted, but most importantly, for success, it requires a genuine collaboration between the patient and the clinician or caregiver to effect optimal recovery. This collaborative relationship must be defined by the unique perspective of each patient. By doing so, we acknowledge the importance of the individual patient’s values, goals, perspectives, and capacity. Rehabilitation scientists can design what arguably is a scientifically sound intervention that is evidence-based and even with preliminary data supporting its efficacy, but if the patient does not value the target outcome, does not fully engage in the therapy, or does not expect the intervention to succeed, the likelihood of success is poor. We offer this opinion, not to be critical, but to suggest a paradigm shift in the way in which we conduct stroke recovery and rehabilitation trials.
Effects of cough-jet on airflow and contaminant transport in an airliner cabin section
Authors: Yang Lin , Li Xiangdong , Yan Yihuan , Tu Jiyuan
Published: December 2017

The goals of this study were to investigate the effect of cough-jet on local airflow and contaminant transport in a typical cabin environment by using computational fluid dynamics. A fully occupied airliner cabin section was employed as the computational domain. Contaminants were released through coughing passengers from different locations inside the cabin. Numerical results in terms of contaminant transport characteristics were examined and compared. It can be concluded that cough-jet has significant effects on air flow in front of cough passenger in a short period of time. Also, it was found that, without considering the cough-jet model, the simulation results could not be a precise representation of the transport and distribution of cough-generated airborne contaminants.
Examining the Status of Transition-Focused Content Within Educator Preparation Programs
Authors: Morningstar Mary E. , Hirano Kara A. , Roberts-Dahm L. Danielle , Teo Natalie , Kleinhammer-Tramill P. Jeannie
Published: December 2017

Almost two decades since the last study of how educator preparation programs (EPPs) offer transition-related content to preservice teachers, this study sought to understand if the educator preparation landscape has changed. Given the impact of well-prepared secondary educators on student transition outcomes, reexamining the status of transition-related content within teacher education was warranted. Thus, the primary purpose of this study was to query a national sample of EPPs regarding the specific transition content provided and methods for conveying transition content to preservice teacher education students. Results indicated that small changes have occurred over time, with most programs reporting positive perspectives regarding the level of preparation among program graduates. However, the capacity of EPPs to offer high quality and evidence-based transition content appears to be inconsistent. This study emphasizes the need for future research, as well as improved practice within EPPs.
A Systematic Analysis of Transition Coursework Required for Special Education Licensure
Authors: Williams-Diehm Kendra L. , Rowe Dawn A. , Johnson Margaret C. , Guilmeus Jean Francois
Published: December 2017

The field of secondary special education and transition has long advocated for quality training at the preservice level. However, transition-focused coursework is not required for all special education licensure programs. Licensure programs requiring this coursework do not cover all transition-related knowledge and skills needed for teachers to implement effective planning and instruction. This article details results from an analysis of syllabi of transition coursework required for licensure sampled from institutions of higher education (i.e., named in 2015 U.S. News & World Report, 2014 National Council on Teacher Quality report). Results found 35% of universities sampled required a transition course for initial special education licensure. Courses identified covered roughly 85% of the subdomains identified in the Taxonomy for Transition Programming 2.0.
Land, Agriculture and Livelihood of Scheduled Tribes in North-East India
Authors: Marchang Reimeingam
Published: December 2017

Land is collectively owned and governed by the community among the Scheduled Tribe (ST) in the north-eastern region. As a result, households without land were less prominent among the ST households, than all-social groups, particularly in the ST-population-dominated states. Private land ownership has also evolved in recent times. Land is the basic resources and agriculture, especially shifting cultivation, is the primary means of livelihood for majority of them. ST households mostly cultivated a small and medium size of land rendering to a subsistence economy. Recently, a gradual relinquish from the dependence of agriculture for employment and livelihood is evident. Concurrently, agricultural income has significantly declined. Ironically, the region continues to produce inadequate food grains production that is insufficient to cater the rapidly growing population. Economy of STs revolves around a subsistence agricultural economy. Nevertheless, ST means of livelihood has converged towards diversified modern market-oriented employment and economy.
Relocation Models for Public Housing Redevelopment Programs
Authors: Kaplan E H
Published: December 2017

The rehabilitation of large public housing projects requires the relocation of project tenants during construction. This paper formulates scheduling models for this relocation problem. A basic model for homogeneous tenant populations is studied in detail, and a promising approximation is discussed. The model is generalized to heterogeneous tenant populations and successfully applied to an actual public housing redevelopment program.
Long-term macrolides in diffuse interstitial lung diseases
Authors: Faverio Paola , Bini Francesco , Vaghi Adriano , Pesci Alberto
Published: December 2017

In the present review we provide currently available evidence for the use of macrolides in the treatment of diffuse interstitial lung diseases (ILDs). Up to now, research on macrolides has mainly focused on three areas. First, macrolides have shown some promising results in cellular models and case reports as antifibrotic agents, by promoting autophagy and clearance of intracellular protein aggregates and acting as regulators of surfactant homeostasis. Secondly, macrolides have an immunomodulatory effect, which has been applied in some organising pneumonia cases. In particular, macrolides have been tested in association with systemic corticosteroids as steroid-sparing agents and alone as either first-line agents in mild cases or second-line agents where steroids were poorly tolerated or had failed. Thirdly, a recent area of research concerns the possible role of macrolides as modulators of lung microbiota and the host–microbiota interaction. This function has been particularly studied in idiopathic pulmonary fibrosis patients, in whom changes in microbiota have been proved to be associated with disease progression. However, the lack of high-quality studies makes the application of macrolide therapy in ILDs a field in which research should be conducted on a large scale.
Sentinel Lymph Node Biopsy Pathology and 2-Year Postsurgical Recurrence of Breast Cancer in Kenyan Women
Authors: Brand Nathan R. , Wasike Ronald , Makhdomi Khalid , Chauhan Rajendra , Moloo Zahir , Gakinya Samuel M. , Neugut Alfred I. , Zujewski Jo Anne , Sayed Shahin
Published: December 2017

Purpose

The goal of this study was to describe the pathologic findings and early follow-up experience of patients who underwent a sentinel lymph node biopsy (SLNB) at Aga Khan University Hospital (AKUH) between 2008 and 2017.

Patients and Methods

We performed a retrospective analysis of women with breast cancer who underwent an SLNB at AKUH between 2008 and 2017. The SLNB was performed on patients with stage I and stage II breast cancer, and identification of the sentinel lymph node was made by radioactive tracer, blue dye, or both, per availability and surgeon preference. Demographic, surgical, and pathologic data, including immunohistochemistry of the surgical sample for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, were abstracted from the patient records. Follow-up data were available for a subset of patients.

Results

Between 2008 and 2017, six surgeons performed SLNBs on 138 women, 129 of whom had complete records and were included in the study. Thirty-one of 129 (24%) had a positive SLNB, including 10 of 73 (14%) with stage I and 21 of 56 (38%) with stage II disease. Seventy-eight patients (60%) received systemic adjuvant chemotherapy and 79 (62%) received radiation therapy, and of the 102 patients who were estrogen receptor positive, 86 (85%) received endocrine therapy. Seventy-nine patients were observed for > 2 years, and, of these, four (5.1%) had a regional recurrence.

Conclusion

The SLNB positivity rates were similar to those of high-income country (HIC) cohorts. However, preliminary data suggest that recurrence rates are elevated at AKUH as compared with those of HIC cohorts, perhaps because of a lower use of radiotherapy and chemotherapy at AKUH compared with HIC cohorts or because of differences in the characteristics of the primary tumor in patients at AKUH as compared with those in HICs.
Oxytocin and Naltrexone Successfully Treat Hypothalamic Obesity in a Boy Post-Craniopharyngioma Resection
Authors: Hsu Eugenie A , Miller Jennifer L , Perez Francisco A , Roth Christian L
Published: December 2017

Context

Hypothalamic obesity, a treatment-resistant condition common to survivors of craniopharyngioma (CP), is strongly associated with a poor quality of life in this population. Oxytocin (OT), a hypothalamic neuropeptide, has been shown to play a role in the regulation of energy balance and to have anorexigenic effects in animal studies. Naltrexone (NAL), an opiate antagonist, has been shown to deter hedonic eating and to potentiate OT’s effects.

Design

In this parent-observed study, we tested the administration of intranasal OT for 10 weeks (phase 1), followed by a combination of intranasal OT and NAL for 38 weeks (phase 2) in a 13-year-old male with confirmed hypothalamic obesity and hyperphagia post-CP resection. Treatment resulted in 1) reduction in body mass index (BMI) z score from 1.77 to 1.49 over 10 weeks during phase 1; 2) reduction in BMI z score from 1.49 to 0.82 over 38 weeks during phase 2; 3) reduced hyperphagia during phases 1 and 2; 4) continued hedonic high-carbohydrate food-seeking in the absence of hunger during phases 1 and 2; and 5) sustained weight reduction during decreased parental monitoring and free access to unlocked food in the home during the last 10 weeks of phase 2.

Conclusion

This successful intervention of CP-related hypothalamic obesity and hyperphagia by OT alone and in combination with NAL is promising for conducting future studies of this treatment-recalcitrant form of obesity.
Classification of breast cancer in ultrasound imaging using a generic deep learning analysis software: a pilot study
Authors: Becker Anton S , Mueller Michael , Stoffel Elina , Marcon Magda , Ghafoor Soleen , Boss Andreas
Published: December 2017

Objective:

To train a generic deep learning software (DLS) to classify breast cancer on ultrasound images and to compare its performance to human readers with variable breast imaging experience.

Methods:

In this retrospective study, all breast ultrasound examinations from January 1, 2014 to December 31, 2014 at our institution were reviewed. Patients with post-surgical scars, initially indeterminate, or malignant lesions with histological diagnoses or 2-year follow-up were included. The DLS was trained with 70% of the images, and the remaining 30% were used to validate the performance. Three readers with variable expertise also evaluated the validation set (radiologist, resident, medical student). Diagnostic accuracy was assessed with a receiver operating characteristic analysis.

Results:

82 patients with malignant and 550 with benign lesions were included. Time needed for training was 7 min (DLS). Evaluation time for the test data set were 3.7 s (DLS) and 28, 22 and 25 min for human readers (decreasing experience). Receiver operating characteristic analysis revealed non-significant differences (p-values 0.45–0.47) in the area under the curve of 0.84 (DLS), 0.88 (experienced and intermediate readers) and 0.79 (inexperienced reader).

Conclusion:

DLS may aid diagnosing cancer on breast ultrasound images with an accuracy comparable to radiologists, and learns better and faster than a human reader with no prior experience. Further clinical trials with dedicated algorithms are warranted.

Advances in knowledge:

DLS can be trained classify cancer on breast ultrasound images high accuracy even with comparably few training cases. The fast evaluation speed makes real-time image analysis feasible.
Recent advances in the management of non-small cell lung cancer
Authors: Shojaee Samira , Nana-Sinkam Patrick
Published: December 2017

Lung cancer is the number one cause of cancer-related death in both men and women. However, over the last few years, we have witnessed improved outcomes that are largely attributable to early detection, increased efforts in tobacco control, improved surgical approaches, and the development of novel targeted therapies. Currently, there are several novel therapies in clinical practice, including those targeting actionable mutations and more recently immunotherapeutic agents. Immunotherapy represents the most significant step forward in eradicating this deadly disease. Given the ever-changing landscape of lung cancer management, here we present an overview of the most recent advances in the management of non-small cell lung cancer.
The emerging landscape of in vitro and in vivo epigenetic allelic effects
Authors: Gregg Christopher
Published: December 2017

Epigenetic mechanisms that cause maternally and paternally inherited alleles to be expressed differently in offspring have the potential to radically change our understanding of the mechanisms that shape disease susceptibility, phenotypic variation, cell fate, and gene expression. However, the nature and prevalence of these effects in vivo have been unclear and are debated. Here, I consider major new studies of epigenetic allelic effects in cell lines and primary cells and in vivo. The emerging picture is that these effects take on diverse forms, and this review attempts to clarify the nature of the different forms that have been uncovered for genomic imprinting and random monoallelic expression (RME). I also discuss apparent discrepancies between in vitro and in vivo studies. Importantly, multiple studies suggest that allelic effects are prevalent and can be developmental stage- and cell type-specific. I propose some possible functions and consider roles for allelic effects within the broader context of gene regulatory networks, cellular diversity, and plasticity. Overall, the field is ripe for discovery and is in need of mechanistic and functional studies.
Uterine fibroids – what’s new?
Authors: Williams Alistair R.W.
Published: December 2017

Uterine fibroids are the commonest benign tumours of women and affect all races with a cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy economic burden of treatment, fibroids have received remarkably little attention compared to common female malignant tumours. This article reviews recent progress in understanding the biological nature of fibroids, their life cycle and their molecular genetic origins. Recent progress in surgical and interventional management is briefly reviewed, and medical management options, including treatment with selective progesterone receptor modulators, are also discussed.
New records and noteworthy lichens and lichenicolous fungi from Pasvik Reserve, Murmansk Region, Russia
Authors: Urbanavichus Gennadii , Urbanavichene Irina
Published: December 2017

Sixteen species of lichens, five lichenicolous fungi and two non-lichenized fungi are reported for the first time for Pasvik Reserve (NW Murmansk Region). Clypeococcum hypocenomycis, Protoparmelia ochrococca and Xylographa vermicularis are new to the Murmansk Region and Xylographa vermicularis is new to Europe. Ten species are rarely recorded for Murmansk Region, European Russia or Russia: Arctoparmelia subcentrifuga, Chaenothecopsis debilis, Lathagrium undulatum, Merismatium nigritellum, Microcalicium disseminatum, Phaeophyscia nigricans, Placynthium asperellum, Protothelenella leucothelia, Stereocaulon capitellatum and Stigmidium leprariae. Fourteen species are new to the biogeographic province of Lapponia petsamoënsis. Two species, Arctoparmelia subcentrifuga and Stereocaulon capitellatum, are included in the Red Data Book of the Murmansk Region. Brief notes, mainly on habitats and distribution, are provided for all species listed.
Further new or interesting lichens and lichenicolous fungi from La Palma (Canary Islands, Spain)
Authors: Boom Pieter P.G. van den , Clerc Philippe
Published: December 2017

Forty-five taxa of lichens and lichenicolous fungi are recorded from La Palma for the first time. Twelve are new to the Canary Islands archipelago. One further species, Didymocyrtis canarienis, is described as new for science. The total number of known taxa from the island La Palma has raised to 874. An alphabetical annotated species list of all taxa with collection localities, substrate and occasional further annotations is presented.
New Estonian records: mosses
Authors: Vellak Kai , Ingerpuu Nele , During Heinjo , Flatberg Kjell Ivar , Leis Mare , Ehrlich Loore , Kannukene Leiti , Kupper Tiiu
Published: December 2017

In 2016 four species new to Estonia have been identified, mainly by checking earlier collections in different herbaria. This addition raises the total number of bryophyte species registered in Estonia up to 598. One species, which was evaluated as extinct in Estonia, has been found in a new locality. Also a variety new for Estonia has been found.
Eva Nilson 07.05.1941–27.07.2017 in memoriam
Authors: Randlane Tiina
Published: December 2017

Estonian lichenologist and ecologist, Ph.D. (dissertation “Biogeochemical ecology of epiphytic lichens in the conditions of pollution” defended in 1989).
Environmental Assessment for Soil Cover of Urban Recreational Objects (Using the Example of Novosibirsk)
Authors: Благодатнова Анастасия , Blagodatnova Anastasiya
Published: December 2017

In this paper has been presented an environmental assessment for the soil cover of Novosibirsk city’s one of the largest recreational objects — culture and recreation park “Zaeltsovsky”. Has been analyzed dynamics of such soil indicators as medium reaction (water and salt soil extracts), hydrolytic acidity, total absorbed bases, soil organic matter, solid residue of soil’s aqueous extract, dry matter’s mass fraction, moisture content and phytotoxicity. An analysis of above mentioned soil’s parameters dynamics has been carried out taking into account a digression stage for ecosystems in recreational facility’ territory. A negative correlation is observed between the ecosystem state and such soil indicators as amount of organic matter and moisture content. A positive correlation is observed between the ecosystem digression stage and soil phytotoxicity indicators. Revealed trends of changing in the soil’s physical-chemical and biological properties give an idea of the ecosystem digression relationship with the above mentioned indicators.
Impacts of Environmental and Biological Factors on Complex Technical Systems
Authors: Лаптев А. , Laptev A. , Бугай Д. , Bugay D. , Александров Анатолий , Aleksandrov Anatoliy , Ларионов Валерий , Larionov Valeriy
Published: December 2017

The analysis of climate change in the Russian Federation has been carried out. It has been shown that the major climate change is occurring in the Arctic zone — increased emissions of carbon dioxide and methane, deep permafrost thawing. Due to the change of climatic conditions, improvement of the ecological situation and wide use of biological cleaning systems for a treatment of industrial and household effluents a change of biological systems is taking place. Natural selection of microorganisms capable to use as a nutritious substratum such previously inert materials as polyethylene and polypropylene is intensified. The change of climatic conditions in which complex technical systems are operated, and the impact of biological and ecological factors on these systems dictate the need for revision of approaches to creation, design and operation of appropriate technical means. Actions for standardization of procedure for products climatic qualification taking into account the influence of newly forming climatic, ecological and biological conditions will allow considerably reduce economic losses from corrosion, aging and biodeterioration of complex technical systems. The work has been carried out in the frame of implementation of complex research area 18 “Climatic Tests for Safety Provision and Protection from Corrosion, Aging and Biodeterioration of Materials, Constructions and Complex Technical System in Natural Environments” (“Strategic Areas for Development of Materials and Their Treatment Technologies for the Period until 2030”).
Estimation of Burning Coal Dumps’ Contribution to Radio-Ecological Situation in the Kemerovo Region
Authors: Тимофеева Светлана , Timofeeva Svetlana , Луговцова Н. , Lugovcova N.
Published: December 2017

The statistical analysis of ionizing radiation sources has been carried out in this paper. It has been revealed that the greatest radiation dose is produced by emission of radon as the main source of natural radiation. It has been determined that the average radiation dose per inhabitant in the Kemerovo region is 4.28 mSv / year, which is close to the irradiation level’s threshold value. The study of radon emission from a burning dump’s surface has been carried out. The contribution of burning coal dumps to the general radiation situation of Kuzbass has been shown.
Urea Using in Piston Engines’ Exhaust Gases Treatment Systems
Authors: Марков В. , Markov V. , Мягков Л. , Myagkov L. , Маластовский Н. , Malastovskiy N. , Блинов А. , Blinov A.
Published: December 2017

Development and updating of systems for internal-combustion engines’ exhaust gases treatment under tightened limits for toxics emissions continues to be an urgent issue. The usage of computational fluid dynamics methods in the design of such systems presents a significant practical value. In this work has been considered and realized a calculation procedure for evaporation and thermal decomposition of urea in SCR-systems based on ANSYS Fluent. The calculated results have been compared with existing experimental data. It has been concluded that the developed calculation procedure can be used for efficiency estimation of SCRsystems for internal-combustion engines’ exhaust gases.
Efficiency of Cold Accumulation and Chilling Machine Usage
Authors: Синцов А. , Sintsov A.
Published: December 2017

This is continuation of author’s works in energy saving area; the work’s aim is to identify opportunities for energy cost reducing when cold producing by vapor compression chilling machine with variable cooling load. Have been considered schemes, in which the stored cold compensates the cooling load’s peaks. Have been presented the results of thermodynamic calculations, which show the possible ranges of chilling machine performance changing while working together with a cold accumulator. As a device for cold reserve storage have been considered an ice accumulator having short, not exceeding a day “charge-discharge” cycle, and a seasonal cold accumulator charged during the winter.
Technical Regulation of Industrial Facilities’ Safety: Decision-Making and Risk Management
Authors: Грановский Э. , Granovskiy E.
Published: December 2017

Two approaches to decision-making for ensuring the safety of an industrial facility are considered: safety requirements have been defined by normative documents and are controlled by the state; safety requirements are accepted by those who create and operate a hazardous object based on its system analysis and risk assessment. Has been performed the system analysis together with determining an impact on the risk of some decisions, regulated by normative documents. It has been shown that these decisions practically do not influence the technological system’s risk and safety, and expenses for their implementation are unjustified. Decisions based on the technological system’s danger analysis with subsequent choice of systems fulfilling safety functions, and requirements for their efficiency and reliability, ensuring a risk reduction to acceptable values, allow ensure safety as the absence of unacceptable risk with optimization of expenses for the safety achieving.
Method for Urban Environmental Safety’s Integral Assessment with the Usage of Logical-Probabilistic Approach
Authors: Плуготаренко Н. , Plutogarenko N. , Долгополова А. , Dolgopolova A.
Published: December 2017

The work has been devoted to development of method for integral assessment of an industrial city’s level of ecological security using the logical-probabilistic approach. The basic methods for integral assessment of negative factors’ impact on industrial cities’ environment and such cities’ population health. Have been developed a logical-probabilistic model for an industrial city’s ecological safety evaluation to predict this city’s development, and method for integrated assessment of industrial city’s ecological safety using logical-probabilistic approach.
Extensão universitária em Relações Internacionais: ditadura e transição à democracia na América do Sul | Science outreach in the field of International Relations: dictatorship and transitional justice in South America
Authors: Dri Clarissa , Da Silva Andressa Caroline Molinari , De Andrade Marina Lazarotto
Published: December 2017

Este artigo traz o relato e a discussão de uma iniciativa de extensão universitária e educação popular promovida no âmbito do curso de Relações Internacionais da Universidade Federal de Santa Catarina. Trata-se de analisar a implementação e os resultados do projeto de extensão “Pedro e o Capitão”, que levou a discussão sobre ditaduras militares e transição à democracia na América do Sul para escolas públicas de ensino médio da grande Florianópolis. A arte foi o método escolhido para dialogar sobre direitos humanos com os jovens, sendo a encenação da peça teatral “Pedro y el Capitán”, de Mario Benedetti, a principal base para a interação. Após análise de conteúdo dos debates com as turmas, conclui-se que o diálogo social sobre o período ditatorial ainda é escasso, o que alimenta a desinformação e opiniões pré-concebidas sobre práticas de violência de Estado.ABSTRACT This paper reports and discusses an initiative of social interaction and popular education organized within the undergraduate career of International Relations of Federal University of Santa Catarina. It analyzes the implementation and the results of the project “Pedro and the captain”, which discussed military dictatorships and democratic transition in South America in secondary public schools in Florianopolis. Art served as a method for human rights dialogue with students, for the play “Pedro y el Capitán”, by Mario Benedetti, was the main basis for interaction. The content analysis of debates among student groups reveals that social dialogue in Brazil on the authoritarian period is still rare, which accounts for lack of information and pre-conceived opinions on State violence. Palavras-chave: Transição democrática. América do Sul. Extensão universitária.Keywords: Democratic transition. South America. University social projects.Recebido em 30 de Julho de 2016 | Aceito em 15 de Setembro de 2017Received July 30, 2016 | Accepted on September 15, 2017DOI: 10.12957/rmi.2016.24898
Daróz, Carlos. O Brasil na Primeira Guerra Mundial: a longa travessia. São Paulo: Editora Contexto, 2016, 208 p. ISBN: 978-85-7244-952-6
Authors: Espósito Neto Tomaz
Published: December 2017

O presente texto examina o livro “O Brasil na Primeira Guerra Mundial: a longa travessia”, de Carlos Daróz, que analisa a atuação brasileira na Primeira Guerra Mundial no período de 1917 a 1919.ABSTRACTThis text examines the book “O Brasil na Primeira Guerra Mundial: a longa travessia” (Brazil in the First World War: a long crossing), by Carlos Daróz, which analyses Brazilian actions in the First World War in the period from 1917 to 1919. Palavras-chave: Política Externa Brasileira; Primeira Guerra Mundial; História das Relações Internacionais.Keywords: Brazilian Foreign Policy; First World War; History of International Relations.Recebido em 03 de Fevereiro de 2017 | Aceito em 11 de Novembro de 2017Received on February 3, 2017 | Accepted on November 11, 2017DOI: 10.12957/rmi.2016.27252
Embaixador Sérgio Tutikian: um pioneiro no Oriente Médio | Ambassador Sérgio Tutikian: a pioneer in the Middle East
Authors: Goldfeld Monique Sochaczewski
Published: December 2017

Sérgio Tutikian é um pioneiro por dois motivos: por um lado é dos primeiros diplomatas de origem armênia nos quadros do Ministério das Relações Exteriores e por outro é o primeiro a de fato ter servido nos postos-chave do Oriente Médio, dominando muitas de suas línguas, aspectos culturais e sensibilidades políticas. O depoimento em questão é uma entrevista de História Oral, do tipo história de vida, em que o entrevistado conta sobre a história da chegada da sua família ao Brasil, no contexto das perseguições porque os armênios passaram no Império Otomano em sua fase final, perpassa o estabelecimento da mesma no Rio Grande do Sul, sua escolha não óbvia pela carreira diplomática, e centra-se então em seus testemunhos sobre passagens no Irã, Iraque e Kuwait, entre outras localidades médio-orientais. ABSTRACTSérgio Tutikian is a pioneer for two reasons: on the one hand, he is one of the first diplomats of Armenian origins in the Brazilian Ministry of Foreign Affairs, and on the other hand he is the first one to have served in the key posts of the Middle East, mastering many local languages, cultural aspects and political sensitivities. The testimony here is an Oral History interview, in which the deponent shares the story of the arrival of his family in Brazil -  in the context of persecutions the Armenians suffered in the last phase of the Ottoman Empire -, their settlement in Rio Grande do Sul, his non obvious choice for the diplomatic career, and then focuses his testimony on events he witnessed in Iran, Iraq and Kuwait, among other Middle Eastern places.Palavras-chave: Diplomacia; Armênios; Diáspora; Oriente Médio.keywords: Diplomacy; Armenians; Diaspora; Middle East.Recebido em 09 de Novembro de 2017 | Aceito em 11 de Novembro de 2017Received on November 9, 20017 | Accepted on November 11, 2017DOI: 10.12957/rmi.2016.31421
Bauman, Zygmunt. Estranhos à nossa porta. Rio de Janeiro: Zahar, 2017, 117P. ISBN 978-85-378-1610-3
Authors: De' Carli Camila
Published: December 2017

O texto traz uma breve resenha do livro Estranhos à nossa porta, do sociólogo e filósofo polonês Zygmunt Bauman, publicado no Brasil pela editora Zahar em 2017. O autor analisa as origens e o impacto do pânico moral gerado pelos intensos fluxos migratórios para a Europa nos últimos anos, assim como o processo de desumanização que envolve os recém-chegados ao continente, que tem transformado as migrações de tema moral em uma questão de segurança.ABSTRACTThis short review examines the book Strangers at our door, written by the sociologist and philosopher Zygmunt Bauman and published in Brazil by Zahar (2017). The author analyzes the origins and the impact of the moral panic generated by the intense migratory flows to Europe in recent years, as well as the process of dehumanization involving the newcomers, wich has made migrations become a matter of security rather than a moral issue.Palavras-chave: Europa, migrações, refugiados.Keywords: Europe, migration, refugees.Recebido em 27 de Novembro de 2017 | Aceito em 29 de Novembro de 2017.Received on November 27, 2017 | Accepted on November 29, 2017.DOI: 10.12957/rmi.2016.31471
APRESENTAÇÃO | PRESENTATION
Authors: Internacional Mural
Published: December 2017

DOI: 10.12957/rmi.2016.31558
Theoretical and analytical study of the phase transition of 1x1-CrN/GaN multilayer
Authors: Espitia R. Miguel J. , Diaz Forero John Hernan , Salcedo Parra Octavio Jose
Published: December 2017

We perform theoretical and analytical study using density functional theory to
investigate the structural stability, structural and electronics properties of the 1x1-
CrN/GaN multilayer in the phases rock-salt, zincblende and wurtzite. Our
calculations indicate that the most stable phase for the multilayer is the hexagonal
wurtzite type, whit possibility of growing in the rock salt by the application external
pressure, we found that the pressure transition is ~ 13,5 GPa. We found that the
multilayer presents a metallic behavior produced by the hybrid orbitals d-Cr and Np
that cross level Fermi.
Propagation of probabilistic uncertainty: the simplest case (a brief pedagogical introduction)
Authors: Kosheleva Olga , Kreinovich Vladik
Published: December 2017

The main objective of this text is to provide a brief introduction
to formulas describing the simplest case of propagation of probabilistic
uncertainty â for students who have not yet taken a probability course.
From bullfighter’s lover to female matador: The evolution of Madonna’s gender displays in her music videos
Authors: Tortajada Iolanda , Araüna Núria , Willem Cilia
Published: December 2017

Throughout her artistic career, Madonna has been notorious for her provocative gender displays. Academic literature has highlighted the ambivalence of many of her performances in this regard: although she occupies masculine spaces and roles, she often adopts positions that are in line with a traditional kind of femininity or with representation patterns that are part of and reinforce patriarchal discourse. Our analysis of Madonna’s music videos reveals the transformation that takes place in the artist’s gender displays. In this analysis we pay special attention to postfeminist features such as self-sexualization and the use of violence. Through three of the artist’s videos that employ the bullfighting metaphor, we see how the representation of femininity embodied by Madonna is transformed – within the framework of a sexual and affective relationship – from her position as a victim and passive female to that of aggressor.
ON THE NEW RECORD OF Lithoselatium kusu Schubart, Liu and Ng, 2009 FROM INDONESIA (CRUSTACEA: BRACHYURA: SESARMIDAE)
Authors: Widyastuti Ernawati , Rahayu Dwi Listyo
Published: December 2017

Lithoselatium kusu Schubart, Liu and Ng, 2009 previously known from Singapore and surrounding areas, in this paper reported for the first time from Indonesia. The specimens for this study were collected from under rocks and coral rubble around mangrove areas in Lingga, Indonesia. The morphological characteristics and differences of the three known species of this genus are presented.
Evolving state grammar for modeling DNA and RNA structures
Authors: Kumar Ajay , Kalra Nidhi , Garhwal Sunita
Published: December 2017

In this paper, we represent bio-molecular structures (Attenuator, Extended Pseudoknot Structure, Kissing Hairpin, Simple H-type structure, Recursive Pseudoknot and Three-knot Structure) using state grammar. These representations will be measured using descriptional complexity point of views. Results indicate that the proposed approach is more succinct in terms of production rules and variables over the existing approaches. Another major advantage of the proposed approach is state grammar can be represented by deep pushdown automata, whereas no such automaton exists for matrix ins-del system.
Editorial (volumen 12, N.° 2): La interfaz “formación de docentes - ejercicio de la docencia”
Authors: Stipcich Silvia
Published: December 2017

Expresiones del saber popular tales como “en la pista se ven los pingos” o “el movimiento se demuestra andando” son representativas de la creencia en que el saber hacer es lo que cuenta en un contexto específico, lo cual, ciertamente, es razonable. La preocupación de los empleadores por la distancia que media entre la formación de los profesionales y su capacidad para ejecutar la profesión aprendida crece constantemente. Esta preocupación también es compartida por los formadores de docentes, los directivos de las instituciones educativas y los propios estudiantes (es decir, los futuros docentes).
The Democratic Theory of the Early Marx
Authors: Raekstad Paul
Published: December 2017

This article presents a novel reading of Marx’s early, pre-1844, democratic theory, and its connection with his early views on alienation. It argues, contra established readings, that Marx had a properly developed theory of alienation prior to his famous
Filling in the Facts
Authors: Vertegaal Alexander
Published: December 2017

This article explores the use of  sign sequences (
BGU I 174 + 189: An Early Roman Contract from Soknopaiou Nesos
Authors: Claytor W. Graham
Published: December 2017

Edition of two fragments from the first volume of BGU, which together form a nearly complete loan drawn up through the writing office of Soknopaiou Nesos in 7 CE.
O.Bankes 50+23 Quittung für unspezifizierte Umlagesteuern
Authors: Reiter Fabian
Published: December 2017

A new edition of two ostraca from Elephantine which belong to one and the same tax-receipt for the payment of unspecified merismoi.
P.Oxy. VIII 1080 A Fresh Edition and Textual Notes on a Miniature Codex of the Apocalypse
Authors: Malik Peter
Published: December 2017

This is an updated edition of P.Oxy. VIII 1080, a miniature codex of the Johannine Apocalypse. Besides further the discussion of the manuscript' s palaeographical and codicological features, it also includes a brief analysis of its text and corrections.
Some Corrections on Egyptian Anthroponyms in Greek Transcription
Authors: Torres Ana Isabel Blasco
Published: December 2017

Some corrections to Egyptian anthroponyms in Greek transcription: anthroponyms misread by editors, ghost names due to printing errors and proper names written in Verschleifung
Integrating Genomic and Proteomic Data: The Integr8 Project
Authors: Pruess Manuela , Kersey Paul , Apweiler Rolf
Published: December 2017

Integr8 (http://www.ebi.ac.uk/integr8/) has been developed to provide an integration layer for the exploitation of genomic and proteomic data. High-quality databases from major bioinformatics centres in Europe are included, and some core data and the relationships of biological entities to each other and to entries in other databases are stored. Thus, a framework exists that allows for new kinds of data to be integrated, and an entity-centric view of complete genomes and proteomes is offered. Integr8 is an automatically populated database, providing different entry points to the data, depending on the user’s entity of interest. The Proteome Analysis database for statistical analysis and the Genome Reviews for annotated genome information are the main developments within the Integr8 project. With the BioMart application, an interactive querying tool for performing customisable proteome analysis and data mining is offered. Future developments will especially focus on the Genome Reviews, including mapping not yet annotated protein sequences onto their corresponding genomes, generating new predictions for non-coding RNA genes, and generally extending the scope to lower metazoan organisms.
Gene prediction by multiple syntenic alignment
Authors: Adi Said S. , Ferreira Carlos E.
Published: December 2017

Given the increasing number of available genomic sequences, one now faces the task of identifying their functional parts, like the protein coding regions. The gene prediction problem can be addressed in several ways. One of the most promising methods makes use of similarity information between the genomic DNA and previously annotated sequences (proteins, cDNAs and ESTs). Recently, given the huge amount of newly sequenced genomes, new similarity-based methods are being successfully applied in the task of gene prediction. The so-called comparative-based methods lie in the similarities shared by regions of two evolutionary related genomic sequences. Despite the number of different gene prediction approaches in the literature, this problem remains challenging. In this paper we present a new comparative-based approach to the gene prediction problem. It is based on a syntenic alignment of three or more genomic sequences. With syntenic alignment we mean an alignment that is constructed taking into account the fact that the involved sequences include conserved regions intervened by unconserved ones. We have implemented the proposed algorithm in a computer program and confirm the validity of the approach on a benchmark including triples of human, mouse and rat genomic sequences.
Dynamic Network Reconstruction from Gene Expression Data Describing the Effect of LiCl Stimulation on Hepatocytes
Authors: Zellmer Sebastian , Schmidt-Heck Wolfgang , Gaunitz Frank , Baldysiak-Figiel Alicja , Guthke Reinhardt , Gebhardt Rolf
Published: December 2017

Wnt/β-catenin signalling plays an important role in zonation of liver parenchyma and in patterning of hepatocyte heterogeneity. A characteristic marker of this heterogeneity is glutamine synthetase, which is expressed only in a subset of pericentrally located hepatocytes. To investigate, whether and how the Wnt/β-catenin signalling pathway is involved a culture of hepatocytes was stimulated by LiCl. This resulted in an increase in the specific GS activity, indicating that the Wnt/β-catenin pathway may participate in regulating GS levels. Affymetrix GeneChip oligonucleotide arrays were used to monitor the gene expression changes during a period from 2 to 24 hours after stimulation by LiCl. Samples from a cultivation without stimulation were used as controls. Based on the gene expression profiles a hypothetic signal transduction network was constructed by a reverse engineering algorithm. The network robustness was tested and the most stable structure was identified.
3D image and graph based Computation of Protein Surface
Authors: Ranganath Aruna , Shet K.C. , Vidyavathi N.
Published: December 2017

The accessible surface of a macromolecule is a significant determinant of its action. The interaction between biomolecules or protein-ligand is dependent on their surfaces rather than their bulk properties. Identifying these local properties of bimolecular surfaces plays a vital role in the area of biomedicine. For example, identifying binding sites, docking etc. In this paper we describe an algorithm for computing the molecular surface of protein. The algorithm considers the 3D structure of the protein as a 3D image. The algorithm constructs a 3D graph corresponding to the size of 3D image data volume; the graph nodes correspond to image voxels.The idea is drawn from the cost minimization in a graph developed by Thedens and Fleagle[1]. The algorithm uses a Dynamic Programming Technique to avoid combinatorial explosion of the legal local surface.