bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Hubungan Kemampuan Metakognisi dengan Kemampuan Pemecahana Masalah pada saat Pandemi Covid 19
Authors: Aldiono M. , Muharrami Laila Khamsatul , Rosidi Irsad , Ahied Mochammad
Published: June 2022

Penelitian ini bertujuan untuk mengetahui hubungan kemampuan metakognisi terhadap kemampuan pemecahan masalah pada saat pandemi Covid 19. Jenis penelitian ini adalah penelitian kuantitatif dengan metode korelasi Product Moment. Penelitian ini dilakukan di Desa Tamberu Barat dengan jumlah sampel 8 siswa laki-laki dan 8 siswa perempuan. Pengumpulan data menggunakan angket MAI (Metacognitive Awarenes Inventory) untuk kemampuan metakognisi dan soal tes pemecahan masalah untuk kemampuan pemecahan masalah. Teknik analisis data menggunakan uji korelasi pearson. Berdasarkan hasil penelitian menunjukkan signifikansi sebesar 0,033 0,05, nilai rhitung sebesar 0,534 ttabel  = 0,3494 yang artinya H0 ditolak dan H1 diterima sehingga terdapat hubungan antara kemampuan metakognisi terhadap kemampuan pemecahan masalah pada saat pandemic Covid 19
Peran Resiliensi, Positive Social Relationships, dan Health Belief terhadap Kesejahteraan Emosi Pasien Hemodialisis
Authors: Istiqomah Nur , Hadjam M. Noor Rochman , Yuniarti Kwartarini Wahyu , Paramastri Ira , Thaha Mochammad
Published: June 2022

Individu didiagnosis dengan penyakit ginjal stadium akhir dan harus menjalani perawatan hemodialisis memiliki implikasi bahwa menjadi tergantung pada pengobatan seumur hidup. Sejumlah studi melaporkan pasien hemodialisis mengalami beban simtom dan terganggunya well-being akibat penyakit maupun perawatan hemodialisis. Penelitian ini bertujuan untuk menguji peran resiliensi, positive social relationships, dan health belief terhadap emotional well-being pasien hemodialisis. Subjek penelitian yaitu pasien penyakit ginjal stadium akhir yang menjalani hemodialisis secara rutin di Instalasi Hemodialisis RSU Dr. Soetomo, Surabaya yang dipilih melalui purposive sampling, artinya dipilih berdasarkan pertimbangan kriteria tertentu dan kesediaan berpartisipasi. Penelitian ini melibatkan pasien hemodialisis sejumlah 55 orang terdiri dari 34 laki-laki dan 21 perempuan, berusia 26 – 60 tahun. Menggunakan metode kuantitatif dengan melakukan survei, pengumpulan data dilakukan menggunakan lima Skala yakni Scale of Positive and Negative Experience (SPANE) dan Satisfaction with Life Scale (SWLS), 10-Item Connor-Davidson Resilience Scale (10-Item CD-RISC), Medical Outcomes Study Social Support Survey (MOS-SSS), dan Skala Health Belief. Analisis data dilakukan dengan analisis statistik uji regresi ganda. Hasil uji regresi ganda menunjukkan bahwa hipotesis ditolak, artinya resiliensi, positive social relationships, dan health belief secara simultan tidak dapat memprediksi emotional well-being pasien hemodialisis (F = 2,363, p 0,05). Secara parsial, berdasarkan nilai t diketahui hanya resiliensi memberi kontribusi signifikan terhadap emotional well-being (t = 2,342, p 0,05), sementara positive social relationships dan health belief masing-masing memberi kontribusi tidak signifikan terhadap emotional well-being. Penelitian berikutnya diharapkan dapat membantu meningkatkan coping resources yakni resiliensi yang bermanfaat mendorong perkembangan emosi positif, serta dapat membantu memberi edukasi terkait penyakit ginjal dan hemodialisis sehingga pasien memiliki pemahaman, respon permasalahan, dan belief yang lebih positif.Kata kunci: emotional well-being, pasien hemodialisis
Impelementasi Pengembangan Kecerdasan Kinestetik Melalui Kegiatan Senam Irama di TK Islam Al Madina Sampangan Semarang
Authors: Kumala Hena Safira Endah , Rahmania Neila Ulfa , Purnama Sigit
Published: June 2022

Kecerdasan kinestetik anak usia dini bisa distimulasi menggunakan aktivitas sederhana dan diminati anak. Senam irama ialah aktivitas yang tepat untuk memberi stimulasi pada anak, karena anak menyukai gerak, apalagi jika diiringi musik dan lagu ceria. Penelitian ini bertujuan untuk mengetahui pengembangan kecerdasan kinestetik melalui kegiatan senam irama di TK Islam Al Madina Sampangan Semarang. Peneliti menerapkan penelitian kualitatif deskriptif, yang mana datanya diperoleh dari pengamatan, interview, dan dokumentasi. Data yang diperoleh akan dianalisis menggunakan analisis deskriptif kualitatif. Senam irama di TK Islam Al Madina dilaksanakan setiap hari sabtu, sebelum kegiatan dimulai anak berbaris, lalu melafalkan ikrar pagi dan asmaul husna, setelah itu anak merentangkan kedua tangannya dan melaksanakan pemanasan bersama. Sarana prasarana yang disiapkan berupa peralatan yang dibutuhkan untuk mendukung terlaksananya aktivitas senam irama. Pengembangan kecerdasan kinestetik pada kelompok B melalui kegiatan senam irama di TK Islam Al Madina terlaksana dengan baik, ditunjukkan melalui rencana, pelaksanaan, dan evaluasi oleh guru pada kegiatan pembelajatan senam irama.
Civil-Military Cooperation in Disaster and Emergency Response: Practices, Challenges, and Opportunities
Authors: Bollen Myriame , Kalkman Jori Pascal
Published: June 2022

Civilian authorities increasingly request military involvement in national emergencies and (inter)national disasters. This article aims to contribute to our understanding of these new civil-military interactions. The authors first reflect on three themes: (1) guidelines, principles, and goals of civil-military cooperation; (2) domain consensus through civil-military agreement on the allocation of areas of responsibility; and (3) militarization processes. The authors describe how these themes feature in traditional, expeditionary civil-military cooperation and in these new civil-military partnerships. Next, the authors consider the effects of the growing military role in emergencies and disasters on civil-military relations. The article concludes with some recommendations and a research agenda.
PLAN E: A Grand Strategy for the Twenty-first Century Era of Entangled Security and Hyperthreats
Authors: Boulton Elizabeth G.
Published: June 2022

A transdisciplinary research project investigated the idea of framing climate and environmental change (CEC) as a new type of threat: a hyperthreat. Traditional military analytical methods were used to assess the hyperthreat and its context and develop ideas about how an adequate response could be conceived. This approach contrasts to prior literature and longstanding geopolitical discourse that identify the risks of taking a securitization approach. Instead, the author argues that it is now riskier not to consider CEC within a mainstream geopolitical and nation-state security strategy. When the hyperthreat of CEC is centered as the main threat to be contained, and its relationship to other threats is analyzed, startling new pathways to stability emerge. The research developed a new theoretical approach called “entangled security” to develop an initial new “grand narrative” and “grand strategy” (PLAN E). This article offers a vision of how military theory can be reimagined to support new policy directions and security priorities.
Implications from the Guard’s Extensive Use: A Cautionary Tale of 2020
Authors: Anderson Michael G.
Published: June 2022

From 2020–22, the National Guard saw extensive use domestically to respond to a wide variety of crises, including natural disasters, civil unrest, pandemics, and border security in addition to overseas deployments. As these emergencies perpetuate, balancing the National Guard’s use domestically and overseas is critical to preserving a sustainable and capable force. It is important for a broader understanding across local, state, and federal governments of the sustainability of these cumulative effects on this force.
The German Military Response to National Disasters and Emergencies: A Case Study of the Flooding in the Summer of 2021
Authors: Juling Dominik
Published: June 2022

In the summer of 2021, a flood of unprecedented intensity occurred in Western Europe. This article describes the German crisis response mechanism to natural disasters with a focus on the deployment and tasks of the German Armed Forces and analyzes challenges and controversies connected with the internal use of the military in Germany after the flood.
Online Monitoring of Inner Deposits in Crude Oil Pipelines
Authors: Giro Riccardo , Bernasconi Giancarlo , Giunta Giuseppe , Cesari Simone
Published: June 2022

The formation of deposits is a very common issue in oil and gas pipeline transportation systems. Such sediments, mainly wax and paraffine for crude oil, or hydrates and water for gas, progressively reduce the free cross-sectional area of the pipe, leading in some cases to the complete occlusion of the conduit. The overall result is a decrease in the transportation performance, with negative economic, environmental, and safety consequences. To prevent this issue, the amount of inner deposits must be continuously and accurately monitored, such that the corresponding cleaning procedures can be performed when necessary. Currently, the former operation is still dictated by best-practice rules pertaining to preventive or reactive approaches, yet the demand from the industry is for predictive solutions that can be deployed online for real-time monitoring applications. The paper moves toward this direction by presenting a machine learning methodology that leverages pressure measurements to perform online monitoring of the inner deposits in crude oil trunklines. The key point is that the attenuation of pressure transients within the fluid is dependent on the free cross-sectional area of the pipe. Pressure signals, collected from two or more distinct locations along a pipeline, can therefore be exploited to estimate and track in real time the presence and thickness of the deposits. Several statistical indicators, derived from the attenuation of such pressure transients between adjacent acquisition points, are fed to a data-driven regression algorithm that automatically outputs a numeric indicator representing the amount of inner pipe debris. The procedure is applied to the pressure measurements collected for one and a half years on discrete points at a relative distance of 40 and 60 km along an oil pipeline in Italy (100 km length, 16-in. inner diameter pipes). The availability of historical data prepipe and postpipe cleaning campaigns further enriches the proposed data-driven approach. Experimental results demonstrate that the proposed predictive monitoring strategy is capable of tracking the conditions of the entire conduit and of individual pipeline sections, thus determining which portion of the line is subject to the highest occlusion levels. In addition, our methodology allows for real-time acquisition and processing of data, thus enabling the opportunity for online monitoring. Prediction accuracy is assessed by evaluating the typical metrics used in the statistical analysis of regression problems.
Novel method to remove bilirubin from the blood of jaundiced rats: a preliminary study
Authors: Hao Jie , Yang Li-Fei , Wan Yong , Yu Jia-Wei , Ren Lu , Zhang Xu-Feng , Lv Yi , Lu Qiang , Ding Hong-Fan
Published: June 2022

BACKGROUNDThe removal of bilirubin from serum is the primary method for treating hyperbilirubinemia. However, currently used treatment methods have several limitations. This study was designed to introduce a novel method to remove bilirubin from the blood of jaundiced rats.METHODSThis novel therapy involved cross-circulation of blood between a rat liver preserved in vitro and a rat with hyperbilirubinemia. All model animals were randomly divided into two groups based on whether they received the novel therapy. Serum samples were collected at different time points. The levels of serum transaminase and bilirubin were detected and compared between different groups. Long-term survival was compared by Kaplan-Meier analysis between different groups.RESULTSAcross different hyperbilirubinemia models, serum total bilirubin level was significantly improved (24.8 ± 1.2 vs. 17.4 ± 1.2 µmol/L, P < 0.05), despite a rise serum transaminase levels after treatment (AST: 4612 ± 382 vs. 5144 ± 390 U/L, P>0.05; ALT: 5051 ± 722 vs. 5488 ± 707 U/L, P<0.05). No necrosis was found in the preserved liver tissue after treatment. This novel treatment significantly raised the long-term survival rates of jaundiced rats (P < 0.05).CONCLUSIONThis novel method could safely and effectively help eliminate bilirubin from the blood of jaundiced rats.
A systematic review of economic evaluations of supervised injection and consumption facilities for people who use drugs: A study protocol.
Authors: Jozaghi Ehsan
Published: June 2022

Background:There are now more than 100 supervised injection facilities (SIFs) operating in numerous jurisdictions, including Australia, Canada and Western Europe. However, despite the increasing prevalence of people who use or abuse illegal drugs, including those who inject drugs, there are currently no operating SIFs in Africa, Asia, Central and South America and Eastern Europe. With the exception of Canada in North America, no sanctioned facility currently operates in the United Mexican States or the United States of America. This is the first study to systematically synthetizes the overall benefits and cost-effective ratios associated with operating SIFs, hypothetical SIFs, or drug consumption sites in different jurisdictions. Methods and Analysis:In this systematic review, through relying on five electronic scientific data bases, the peer-reviewed studies, reports, and theses that have evaluated the cost and benefits of supervised injection or consumption facilities will be identified. Based on the inclusion criteria, all initial articles will be identified and screened via title and abstract. All the articles collected through the initial search will be additionally screened to extract further information and data related to costs, benefits, programs, or services. The final data analysis will include the average cumulative benefits, costs, and ratios associated with operating SIFs. Discussion:This review has the potential to provide evidence-based knowledge related to the cost-savings of public health interventions implemented via harm reduction approaches for marginalized populations. However, it is important to emphasize that SIFs are an integral part of health care system for the marginalized populations and their establishments should not be based on health care costs, rather based on human rights. Systematic review registration: PROPSERO CRD42018100324
Prevalence and Postpartum Screening Practice for Type 2 Diabetes following GDM in King Abdulaziz Medical City: A 3-Years Retrospective Cohort Study.
Authors: Alzahrani Abdullah , Alfitni Daniyah , Aqeel Maysaa , Alsulami Ebtesam
Published: June 2022

Aim
GDM patients were associated to develop T2DM but mostly failed to undergo screening after delivery. This study aims to examine the practice of T2DM screening and prevalence of developing T2DM among women who had GDM in King Abdulaziz Medical City (KAMC), Saudi Arabia.
Methods
Retrospective study involving 642 pregnant women with GDM. Medical records on screenings conducted, delivery mode, GDM and diabetes family history were collected and investigated. Statistical analysis was conducted. Frequencies and percentages were used for categorical variables while means and SD for continuous. Chi-square and t-test were used to establish relationship of categorical and comparing two group means, respectively.
Results
Patients were 98.8% Saudi nationals, mean weight, height, parity and number of pregnancies were 76.96 kg, 2.74 m, 3.37 and 1.35, respectively. Majority were obese (56.9%), SVD (56.4%) mode of delivery and good lifestyle (91.4%) as management practice. OGTT was used for screening T2DM with 0 hr fasting and 2-hrs after consuming 75g of glucose, physician ordered 6 weeks after delivery. Only 20% had screening for T2DM and 3.9% developed postpartum diabetes with high number of women not returning for ordered OGTT screening (65.6%). Significant predictors identified were parity and mode of delivery for development of T2DM, while only mode of delivery for both screening for T2DM and management of GDM.
Conclusion
Low prevalence of developing T2DM but high number of women failed to follow the ordered OGTT screening. Effort on the implementation of OGTT screening for T2DM needs improvement.
How to engage health care workers in the evaluation of hospitals: development and validation of BSC-HCW - a cross-sectional study
Authors: Amer Faten , Hammoud Sahar , Khatatbeh Haitham , Alfatafta Huda , Alkaiyat Abdulsalam , Nour Abdulnaser Ibrahim , Boncz Imre , Endrei Dóra
Published: June 2022

Organizations worldwide utilize the balanced scorecard (BSC) for their performance evaluation (PE). This research aims to provide a tool that engages HCWs in BSC implementation (BSC-HCW). Additionally, it seeks to translate the BSC-HCW to Arabic and validate it at Palestinian hospitals. A cross-sectional study, 454 questionnaires were retrieved from 14 hospitals. The composite reliability (CR), interitem correlation (IIC), and corrected item total correlation (CITC) were evaluated. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used. In both EFA and CFA, the scale demonstrated a good level of model fit. All the items had loadings greater than 0.50. All factors passed the discriminant validity. Although certain factors’ convergent validity was less than 0.50, their CR, IIC, and CITC were adequate. The final best fit model had nine factors and 28 items in CFA. The BSC-HCW is the first self-administered questionnaire to engage HCWs in assessing the BSC dimensions following all applicable rules and regulations. The findings revealed that this instrument’s psychometric characteristics were adequate. Therefore, the BSC-HCW can be utilized to evaluate BSC perspectives and dimensions. It will help managers highlight which BSC dimension predicts HCWs’ satisfaction and loyalty and examine differences depending on HCWs’ and hospital characteristics.
The Transient Deformation of Timoshenko’s Plate
Authors: Serdyuk Dmitry Olegovich , Fedotenkov Grigory Valer'evich
Published: June 2022

In this paper we will present an approach to constructing of dynamical spatial Green’s function (elementary solutions, dominant function) for a thin infinite elastic plate of constant thickness. The plate material is anisotropic with a single plane of symmetry, geometrically coinciding with plate’s middle plane. The Timoshenko theory was used for describing the plate movement. Transient spatial Green’s functions for normal displacements and angles of orthogonal alteration to middle surface before deformation of material fiber are built in the Cartesian coordinate system.To construct the Green’s function direct and inverse Laplace and Fourier integral transformations are applied. The originals of Laplace Green’s functions were analytically found with the theorem of residues. To construct Fourier originals a specific method was used based on Fourier series transformation inversion integral connection with Fourier series on a variable interval.Green’s function found for normal displacement made it possible to represent the normal transient function as threefold convolution of Green function with distant load function. The functions of normal distant displacements were constructed in case of the impact of transient total loads concentrated and distributed across rectangular courts. The numerical method of rectangles was used to calculate the convolution integrals. The influence of the concentrated load speed on transient normal displacements of the anisotropic plate was analyzed. As a verification of constructed transient spatial Green’s functions the results of numerical solutions were compared with the results found using known transient Green’s functions for isotropic thin elastic rectangular simply supported Timoshenko’s plate which solutions are constructed using Laplace integral transformation in time and its decomposition into Fourier TS on coordinates. Besides, its confidence was proved analyzing the nature of waves in anisotropic, orthotropic and isotropic plate, found in the process of numerical calculations. The results are represented as diagrams. Examples of calculations are given.
Population attributable fractions for risk factors and disability burden of dementia in Jiangxi Province, China: A cross-sectional study
Authors: Wu Yuhang , Zheng Huilie , Xu Fenfei , Guo Jin , Liu Zhitao , Wang Shengwei , Chen Xiaoyun , Cao Yu , Zou Wei , Hu Songbo
Published: June 2022

Background: In view of the fact that there is no effective treatment for dementia, the number of years that dementia patients have to live with dementia will gradually increase for the rest of their lives, and the disability loss caused by dementia will increase. It is urgent to study the influence of risk factors on dementia by making use of the potential of prevention. The purpose of this study is to quantify the burden of dementia disability attributable to risk factors by assessing the population attributable fractions (PAFs) in Jiangxi Province, which is one of the regions of moderate aging process of China.Methods: The prevalence data of nine risk factors were obtained through the Sixth National Health Service Survey in 2018, which covered 2713 older people. Levin’s formula was used to calculate the PAF for each risk factor for dementia. We adjusted the PAF for communality between risk factors, and used these values to calculate overall weighted PAFs and the years lived with disability (YLDs), which were attributable to nine risk factors.Results: The number of dementia cases and their proportions that can theoretically be prevented by nine identified risk factors were 111636 (99595-120877) and 66.8% (59.6-72.3), respectively. The total YLDs of dementia were estimated to be 61136 (46463-78369) (males: 36434 [24100-49330], females: 23956 [14716-34589]). Physical inactivity (11639 [8845-14920]), low social contact (9324 [7086-11952]), and hearing loss (5668 [4307-7265] were the top three contributors to dementia.Conclusions: The moderate aging areas represented by Jiangxi Province have great potential in the prevention of dementia. Targeted interventions and management of risk factors can effectively reduce the disability burden of dementia.
Recurrent Closed Loop Bowel Obstruction in Third Trimester of Pregnancy: Case Report and Review of Literature
Authors: Araji Tarek , Wang Stephanie , Kandalaft Nadeem , Estroff Jordan , Ahmadzia Homa K.
Published: June 2022

Intestinal obstruction in pregnancy is an uncommon event. It is a high-risk emergency for both the mother and fetus. Diagnosis of obstruction in pregnancy is often delayed due a multitude of reasons including the nonspecific presentation of symptoms, normal laboratory values and hesitancy to perform necessary imaging studies. Closed loop bowel obstruction (CLBO) is a rare type of intestinal obstruction that compromises blood flow, and it is a surgical emergency that requires prompt intervention. We present of case of CLBO in a pregnant patient at 27 weeks of gestation. Unique to her situation was this diagnosis was the second time in the same pregnancy. Our patient had a necrotic bowel segment removed via an open laparotomy. The remainder of her pregnancy was uncomplicated, and she delivered at term a viable male via planned cesarean delivery.
Finishing of grazing crossbred steers supplemented with detoxified castor bean meal (Ricinus communis L.) in the rainy-dry transition period
Authors: Melgar Osman Ronaldo Aguilar , Silva Robério Rodrigues , Silva Fabiano Ferreira da , Santos Laize Viera , Lima Antônio Carlos Ribeiro , Machado Silvia Layse Mendes , Duenez Wbeimar Yamit Sanchez , Santos Marceliana da Conceição , Devia Diana Carolina Cediel , Paixão Tarcísio Ribeiro , Silva João Williams Dias , Costa Gabriel Dallapicola Da , de Carvalho Gleidson Giordano Pinto
Published: June 2022

This study examined different levels of replacement of soybean meal with detoxified castor bean meal in the finishing of crossbred steers on Brachiaria brizantha cv. Marandu pasture during the rainy-dry transition period. Forty Holstein-Zebu crossbred steers with an average initial weight of 395.93 ± 10 kg were randomly allocated to four treatment groups that were supplemented with concentrate containing different levels of castor bean meal replacing soybean meal (0, 30, 60, or 90%; at 0.4% body weight [BW]). The experimental period was 112 days. A completely randomized experimental design was adopted; with regression analysis conducted using the Statistical and Genetic Analysis System (SAEG). Intake and digestibility of dry matter (DM) and nutrients and animal performance were evaluated. The replacement of soybean meal with castor bean meal did not influence (P>0.05) the intakes of DM (kg day-1), organic matter (OM, kg day-1), neutral detergent fiber (NDF, kg day-1 and %BW), non-fibrous carbohydrates (NFC, kg day-1), or total digestible nutrients (kg day-1). However, the intakes of crude protein (CP) and ether extract (EE, kg day-1) decreased as the replacement levels were increased (P<0.05). The digestibility of DM, OM, NDF, and EE did not change, whereas CP digestibility decreased linearly and NFC digestibility increased linearly (P<0.05). The replacement levels did not affect (P>0.05) final live weight, average daily gain, feed conversion, or carcass yield. Detoxified castor bean meal can replace up to 90% of soybean meal in the composition of the supplement without compromising the production performance of steers on Brachiaria brizantha cv. Marandu pasture during the rainy-dry transition period.
ATG5 promotes head and neck squamous cell carcinoma by regulating translation and cell cycle
Authors: Weng Junquan , Liu Huijuan , Zhang Hui , Tang Su , Fan Haidong
Published: June 2022

IntroductionHead and neck squamous cell carcinoma (HNSCC) is the most prevalent malignant tumor of the maxillofacial area. ARGs (autophagy-related genes) are involved in the cell cycle and translation, which will fuel carcinogenesis. Material and methodsTCGA data for ARGs in HNSCC were analyzed. The functional role of the ATG5 in HNSCC was investigated through ATG5 knockdown cell lines.ResultsAccording to the TCGA data, ATG5 was shown to be an adverse prognostic marker. Regardless of tumor stage, grade, or clinical characteristics, HNSCC patients with high ATG5 expression had a poorer survival rate. ATG5 knockdown suppressed the malignant features of HNSCC cell lines. The mechanism study demonstrated ATG5 knockdown could prevent the malignant phenotype of HNSCC by reversing the cell cycle and translation. One of the systems influencing cell cycle control in ATG5-dependent ways might include HDAC2, TTK, and CDK1. MRPL18, MRPL13, and MRPS14 might all be implicated in ATG5-dependent translation regulation.Discussion and conclusion The current research suggests that ATG5 is a key player in cell cycle and translation regulation, as well as poor prognosis in HNSCC.
Pre-training Protein Models with Molecular Dynamics Simulations for Drug Binding
Authors: Wu Fang , Zhang Qiang , Radev Dragomir , Wang Yuyang , Jin Xurui , Jiang Yinghui , Li Stan Z. , Niu Zhangming
Published: June 2022

The latest biological findings discover that the motionless 'lock-and-key' theory is no longer applicable and the flexibility of both the receptor and ligand plays a significant role in helping understand the principles of the binding affinity prediction. Based on this mechanism, molecular dynamics (MD) simulations have been invented as a useful tool to investigate the dynamical properties of this molecular system. However, the computational expenditure prohibits the growth of reported protein trajectories. To address this insufficiency, we present a novel spatial-temporal pre-training protocol, PretrainMD, to grant the protein encoder the capacity to capture the time-dependent geometric mobility along MD trajectories. Specifically, we introduce two sorts of self-supervised learning tasks: an atom-level denoising generative task and a protein-level snapshot ordering task. We validate the effectiveness of PretrainMD through the PDBbind dataset for both linear-probing and fine-tuning. Extensive experiments show that our PretrainMD exceeds most state-of-the-art methods and achieves comparable performance. More importantly, through visualization, we discover that the learned representations by pre-training on MD trajectories without any label from the downstream task follow similar patterns of the magnitude of binding affinities. This strongly aligns with the fact that the motion of the interactions of protein and ligand maintains the key information of their binding. Our work provides a promising perspective of self-supervised pre-training for protein representations with very fine temporal resolutions and hopes to shed light on the further usage of MD simulations for the biomedical deep learning community.
Comparison of Three Different Biomaterials Used In In Vitro Molar Apexification Models
Authors: DUMAN Canan , Kalaoglu Elif Ece , CAPAN Belen SIRINOGLU , OCAK Mert , BILECENOGLU Burak
Published: June 2022

Objectives: New biomaterials had some advantages such as mixing and easier application as compared to traditional MTA in single-step apexification method. This study aimed to compare the three biomaterials used in the apexification treatment of immature molar teeth in terms of the time spent, the quality of the canal filling and the number of x-rays taken to complete the process.Methods: The root canals of the extracted thirty molar teeth were shaped with rotary tools. To obtain the apexification model, ProTaper F3 was used retrograde. The teeth were randomly assigned into three groups based on the material used to seal the apex; Group 1:Pro Root MTA, Group 2:MTA Flow, Group 3: Biodentine. The amounts of the filling, the number of radiographs taken until treatment completion and the treatment duration were recorded. Then teeth were fixed for micro computed tomography imaging for quality evaluation of canal filling.Results: Biodentine was superior than the other filling materials according to time. MTA Flow provided greater filling volume than the other filling materials in the rank comparison for the mesiobuccal canals. MTA Flow had greater filling volume than ProRoot MTA in the palatinal/distal canals(p=0.039). Biodentine had greater filling volume more than MTA Flow in the mesiolingual/distobuccal canals(p =0.049).Conclusions: MTA Flow was found as a suitable biomaterial according to the treatment time and quality of root canal fillings.
Assessment of Carbon Emission Reduction Contribution of Chinese Power Grid Enterprises Based on MCS-GA-ELM Method
Authors: Li Jinchao , Sun Zihao , Lu Shiqiang
Published: June 2022

To achieve China's "double carbon" goal, it is necessary to make quantitative evaluation of the power grid enterprises’ contribution to carbon emission reduction. This paper analyzes the contribution of power grid enterprises to carbon emission reduction from three points: power generation side, power grid side and user side. Then, PLS-VIP method is used to screen the key influencing factors of carbon emission reduction contribution of power grid enterprises from three aspects: consumption of clean energy emission reduction, reduction of line loss emission reduction and substitution of electric energy. Based on GA-ELM combined machine learning algorithm, we establish an intelligent evaluation model of power grid enterprises’ carbon emission reduction contribution. Furthermore, according to the distribution law of key influencing factors, this paper uses Monte Carlo method to calculate the contribution of power grid enterprises to carbon emission reduction by scenario, so as to evaluate the contribution of power grid enterprises to carbon emission reduction. Finally, combined with the relevant data of power grid enterprises from 2003 to 2019, this paper makes an empirical study on the completion of carbon emission reduction contribution and the promotion path.
Glucocorticoid Receptor Regulated KCNA5 Mediates Cell Proliferation in Human Fetal Membranes
Authors: Cunningham Sarah J , Barrera Alejandro , Sankaranarayanan Laavanya , Allen Terrence K , Reddy Timothy E
Published: June 2022

Preterm birth is a major public health issue, affecting approximately 10% of pregnancies in the United States. A major identifiable cause of preterm birth is preterm premature rupture of membranes (PPROM). PPROM is a pregnancy complication in which the amnion and chorion weaken and rupture prior to 37 weeks of pregnancy and before contractions have begun. PPROM is responsible for 30–40% of preterm birth cases. Recently, PPROM has been closely linked to maternal stress, leading us to hypothesize that glucocorticoid signaling may contribute to PPROM. We measured the gene expression effects of glucocorticoids in primary amnion cells using RNA-seq. KCNA5 emerged as a potential GR regulated gene. To measure the effects of KCNA5 on cell proliferation in primary amnion epithelial cells, we used siRNA to reduce KCNA5 expression and Cas9-based epigenome editing to increase KCNA5 expression in HEK293T cells; followed by cellular assays to measure effects of proliferation and apoptosis. KCNA5 knockdown significantly increased cell proliferation without appearing to impact apoptosis. CRISPR-mediated over expression of endogenous KCNA5 significantly decreased cell proliferation. Decreases in amnion epithelial proliferation could impair the ability of these cells to repair microfractures in the membrane and lead to overall membrane weakening consistent with PPROM.
Pathogenomic analysis of Macrococcus caseolyticus Strain DaniaSudan
Authors: Ali Dania , Bakrye Afar Al , Nasri Hind , Khaier Mona
Published: June 2022

This study pathogenomic to gain genetic characterizations of the first pathogenic strains of Macrococcus caseolyticus, obtained from the donkey in Sudan. The in-silico analysis revealed that a total of (714 genes) were associated with carbohydrate metabolism (187 genes), amino acid and derivatives (138 genes), protein metabolism (163 genes), cofactors, vitamins, prosthetic groups, pigments (103 genes), membrane transport (26 genes), RNA metabolism (37 genes) and stress response (29 genes). In addition, (31 genes) identified in the strain were involved in virulence, disease, and defense. Multiple antibiotic resistances were revealed (13gens) including methicillin resistance (mecI, mecA, mecR1) penicillin binding (PonA, pbpA, pbpH, pbpF and pbpB), Multidrug resistance (mdtH_1, ykka, ykkc and mdtH_2), Tetracycline resistance (tetA, tet38), multidrug export (emrB), multidrug efflux pump (sdrM, sepA) and putative multidrug resistance (emrK). Also, stress responses were (yug1_1, yug1_2, ydaG, ysnF, ydaD and ysnF) and cold shocks were (cspA_1, cspA_2 and cspG). Furthermore, hemolysin (HyA), staphylococcal secretory antigen (ssaA2, ssaA) and (7) seven Murein hydrolase regulation and cell death were identified. The organism consists of Tetracycline resistance gene in the plasmid and Three CRISPRs dan_contig_1, dan_contig_14 and dan_contig_27. The probability of being a human pathogen is 0.253 (PathogenFinder algorithm). Strain DaniaSudan is the first pathogenic strain of Macrococcus caseolyticus isolated from animal.
Fate of Non-Recyclable Plastic Wastes: Material Flow Analysis, Leakage Hotspot Modelling, and Management Strategies
Authors: Rinasti Aprilia Nidia , Ibrahim Indradhi Faisal , Gunasekara Kavinda , Koottatep Thammarat , Winijkul Ekbordin
Published: June 2022

Low priority on waste management has impacted the complex environmental issue, where this study found out up to 24.3% of waste generation in Jakarta and Bandung is emitted to the waterway due to the high intensity of human activity in the urban area. In this study, we investigated the viable integration between material flow analysis and leakage hotspot modelling to improve the management strategy of the plastic pollution in the water system and open environment. Using the multi-criteria assessment through the plastic leakage from its management, a material flow analysis has developed on the city scale. Comprehensively identifying using potent identification and hydrological characterization, plastic waste from Jakarta city has occasionally estimated 2603 ton discarded to Ciliwung River while the plastics from Bandung Area has contributed to 1547 ton, addressing Cikapundung River as the main tributary of Citarum mainstream in annual basis.
Horizontal, random, and vertical structuring of cellulose nanofibres by one-pot electrophoretic and electrochemical deposition
Authors: Kasuga Takaaki , Saito Tsuguyuki , Koga Hirotaka , Nogi Masaya
Published: June 2022

Biomimicry and the development of sophisticated materials can derive inspiration from the nanoscale component orientation and hierarchical structures found in living organisms. Herein, a simple and flexible strategy to construct a sophisticated hierarchical structure based on electrophoretic and electrochemical deposition is reported. Cellulose nanofibres (CNFs), which were used as model materials, were deposited on anode in an aqueous dispersion and fixed in an oriented state, which could be seamlessly altered from horizontal to vertical orientation relatively to the electrodes depending on the applied voltage between the electrodes. The oriented CNF hydrogels not only exhibited anisotropic mechanical properties but also formed complex orientations and hierarchical structures, such as cartilage- and plant stem-like configurations upon varying the electrode shape and applied voltage. This electrophoretic and electrochemical approach was also applied to achieve control over the drying-related shrinkage of the CNF hydrogels, which enabled the fabrication of highly functional dried moulded materials made of rigid CNFs. This simple and flexible technology has the potential to be applied to various materials and thus is expected to contribute to a wide range of fields, such as biomimicry, the formation of highly functional materials made of nanomaterials, and the production of sustainable and functional mouldings.
Experimental study on injection of ferrous sulphate for remediation of a clayey soil contaminated with hexavalent chromium
Authors: Hu Guang , He Yong , Zhu Kao-fei , Zhang Zhao , Lou Wei , Zhang Ke-neng , Chen Yong-gui , Wang Qiong
Published: June 2022

In-situ remediation of the Cr(Ⅵ) contaminated clayey soil remains challenging due to the low hydraulic conductivity and high ion adsorption capacity of the clays. In this study, the injection tests of ferrous sulphate (FeSO4) for a clayey soil contaminated with hexavalent chromium (Cr(Ⅵ)) were performed to explore the feasibility of FeSO4 solution for remediation of Cr(Ⅵ) contaminated soil under different injection pressures. The results show that the injection of FeSO4 solution under the pressure of 30 kPa, 70 kPa, and 100 kPa caused the hydraulic conductivities of the specimens to decrease by 36.5%, 38.7% and 32.2%, respectively. This phenomenon could be attributed to the formation of the mixed iron(Ⅲ)/chromium(Ⅲ) hydroxide, a process for which scanning electron microscopy with energy-dispersive X-ray microanalysis provided direct evidence. Moreover, the mobility capacity of Fe(Ⅱ) was stronger under high pressure (70 kPa, 100 kPa) as indicated by Fe profiles in specimens after remediation under different injection pressures. The range of iron increment at 100 kPa was 3.2–11.9 (g/kg). However, the maximum iron increment at 30 kPa was only 5 (g/kg) and the migration of Fe(Ⅱ) was limited, which was less than 2.5 cm. In addition, the injection pressure of 70 kPa was the most efficient for remediation of Cr(Ⅵ) contaminated soil under the experimental condition in present work, which the remediation efficiency was 87.43%-95.12%. As injection pressure increased, Cr(Ⅵ) leaching increased. Therefore, these experimental results can be used as a reference for remediation of chromium contaminated soil by in-situ injection.
Mitral paravalvular leak 3D printing from 3D-transesophageal echocardiography – proof of concept and preparation flowchart
Authors: Jędrzejek Marek , Kozłowski Michał , Jadczyk Tomasz , Peszek-Przybyła Ewa , Pysz Piotr , Wojakowski Wojciech , Smolka Grzegorz
Published: June 2022

Paravalvular leaks (PVLs) can be detected in almost 15% of patients after mitral valve prosthesis implantation. This complication can result in congestive heart failure and hemolysis. Despite advancements in non-invasive imaging, percutaneous closure of PVLs is not always successful. Therefore, efforts are made to improve treatment outcomes by using 3D-printed models of defects as pre-procedural support for interventional cardiologists. Retrospectively, 3D-TEE recordings of 8 patients with clinically significant mitral PVLs were analysed. Qlab Software was used to export DICOM images of each PVL channel, including surrounding tissue. Image segmentation was performed in 3D Slicer, a free, open-source software package used for imaging research. Models were printed to actual size with the polyjet Stratasys Objet 30 printer with a transparent, rigid material. Duration of model preparation and printing, as well as total cost were calculated. Mean total time of model preparation was 430,5 ± 196 min. 3D-printing from 3D-TEE is technically feasible. Both shape and location of PVLs are preserved during model preparation and printing. It remains to be tested if 3D-printing would improve outcomes of percutaneous PVL closure.
Regulation of human trophoblast gene expression by endogenous retroviruses
Authors: Branco Miguel , Frost Jennifer , Amante Samuele , Okae Hiroaki , Jones Eleri , Ashley Brogan , Lewis Rohan , Cleal Jane , Arima Takahiro , Maffucci Tania , Caley Matthew
Published: June 2022

The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate genetic variation and affect host gene regulation, may have helped to define species-specific trophoblast gene expression programmes. Here, we assessed the contribution of transposable elements to human trophoblast gene expression as enhancers or promoters. Using epigenomic data from primary human trophoblast and trophoblast stem cell lines, we identified multiple endogenous retrovirus families with regulatory potential that lie close to genes with preferential expression in trophoblast. These largely primate-specific elements are associated with inter-species gene expression differences, and are bound by transcription factors with key roles in placental development. Using genetic editing we demonstrated that several elements act as transcriptional enhancers of important placental genes, such as CSF1R and PSG5. We also identified an LTR10A element that regulates ENG expression, affecting secretion of soluble ENG, with potential implications for preeclampsia. Our data show that transposons have made important contributions to human trophoblast gene regulation, and suggest that their activity may affect pregnancy outcomes.
Global research trends on diseases in the elderly population: a visualization analysis
Authors: Zhao Lei , Zhao Min
Published: June 2022

Background
Currently, populations around the world are rapidly ageing. Hence, the number of scientific publications on diseases in the elderly population (aged 60 and over) has been expanding.
Objective
This study aimed to use bibliometric analysis method to illustrate the global research trends over the past 20 years and to summarize the research hotspots that are likely to be addressed in future studies.
Methods
A literature search for medical publications on diseases in the elderly population in the period from 2000 to 2021 was conducted in the Web of Science Core Collection on April 20, 2022. Visualization analysis was performed using VOSviewer software (version 1.6.16).
Results
A total of 12,108 publications of the period from 2000 to 2021 were retrieved. The annual publication output grew gradually from 177 in 2000 to 1,236 in 2021. Articles (n = 10,264, 84.77%) were the most common type of documents. The USA issued the largest number of publications (n = 3,632, 30.00%) and had the most citations (citations = 141,230), with the United States Department of Health and Human Services making the largest contribution (n = 1,904, 15.73%). The Lancet had the most citations (citations = 28,548). A total of 545 meaningful topics were identified and further classified into 5 different clusters. The keywords ‘COVID-19’, ‘muscle mass’, ‘depression’ and ‘non-alcoholic fatty liver disease’ have drawn substantial attention in recent years, indicating that these areas will be the centre of attention in future studies on the elderly population.
Conclusions
This study provides an unbiased visualization analysis of this topic in a scale-efficient manner and includes directions for further research.
Non-covalent immobilized sultone based protic ionic liquids on nano silica sulfuric acid as novel heterogeneous catalysts for the efficient synthesis of tetrazolopyrimidines
Authors: Taib Layla A. , Keshavarz Mosadegh
Published: June 2022

In this research work, a novel strategy for the heterogenization of sultone based acidic ionic liquids via their non-covalent immobilization on nano silica sulfuric acid is reported and the catalytic ability of the prepared heterogeneous catalysts for the synthesis of tetrazolopyrimidines derivatives is investigated. The physicochemical properties of the prepared catalysts were studied using thermal and spectroscopic techniques such as 1H and 13C NMR, FTIR, SEM, TEM, TGA, EDX and BET. In the following, tetrazolopyrimidine derivatives were synthesized in the presence of the prepared heterogeneous supported acidic ionic liquids on nano silica sulfuric acid in a three-component reaction of aromatic aldehydes, 5-aminotetrazole and active methylene compounds. The obtained results showed that the supported protic ionic liquids have better catalytic activity than their non-supported forms. Moreover, the recoverability, reusability and thermal stability of the acidic ionic liquids were also significantly improved by immobilization on nano silica sulfuric acid.
The Association Between Dietary Calcium Intake and Hyperuricemia Among Chinese Adults
Authors: Zhang Huanxiang , Gu Xia , Wang Shanjie , Sui Xiaofang , Qiu Hongbin , Zhang Yiying
Published: June 2022

Background
Previous studies demonstrated that dietary nutrients intake is associated with the risk of hyperuricemia. Calcium, acting as an essential nutrient in human body, therefore, may be associated with hyperuricemia. However, until now, no studies have independently assessed the association between dietary calcium intake.
Methods
7,606 participants aged 18–94 years from the China Health and Nutrition Survey (CHNS) in 2009 were extracted. Three consecutive 24 dietary recalls were used to assess all dietary intake. Multivariable logistic regression and restricted cubic spline (RCS) was performed to evaluate the relationship between dietary calcium intake and hyperuricemia after adjustment for confounders.
Results
The crude prevalence of hyperuricemia was 15.67% (20.51% for male, 11.66% for female). A positive association between dietary calcium intake and risk of hyperuricemia even in the fully adjusted model. Compared with the lowest quintile, the odds rations for hyperuricemia were 1.130 [95% confidence interval (CI): 0.885–1.441], 1.257 (95% CI: 0.987–1.600), 1.309 (95% CI: 1.020–1.680), and 1.552 (95% CI: 1.180–2.041) for the second to highest quintiles of dietary calcium intake, respectively (P for trend = 0.015), and a positive dose-response relationship was observed.
Conclusions
Higher dietary calcium intake is associated with an increased risk of hyperuricemia independent of some major confounding factors.