bluuebunny/crossref_metadata_2025 huggingface dataset:
The conditions for the young teachers’ professional development in the space of a pedagogical university
Authors:   Altai State Pedagogical University, Shamarina Elena Vladimirovna
Published: December 2021

Contemporary challenges of the education system cause the growth of professional difficulties for the young teachers, reduce the effectiveness of their adaptation and consolidation in the educational institutions. The monitoring of professional deficient conditions of the young teachers allows these difficulties to be leveled on time, thereby improving the quality of their adaptation, consolidation, and professional self-identification. The theory and methodology of minimizing professional difficulties have been studied by scientists, but each region has its own specifics of the development of the education system and the peculiarity of supporting the professional development of young specialists. This makes it possible to conceptually define a methodology for identifying professional difficulties of the young teachers of Altai Krai and develop a mechanism for implementing individual educational routes. The purpose of this work is to identify the conditions for the young teachers’ professional development in the space of a pedagogical university. Methods. The methodological basis consists of a systematic approach as the basis for diagnosing professional difficulties of the young teachers; a competence-based approach as the basis for structuring professional difficulties. The research uses the method of collecting primary information, the method of analysis, generalization, information processing, and the design method. The results of the study are the following. The technology of the annual career guidance event «The Job Fair» with the involvement of employers as active participants is described. Questionnaires are developed for employers and young specialists to identify professional difficulties of a group of young teachers. The monitoring of the young teachers’ deficient conditions was carried out. Twelve additional professional training programs are developed for the young teachers of Altai Krai. A mechanism for building and implementing of a professional development individual trajectory has been made. The results of employers’ diagnostics and a list of professional development programs are presented.
Analysis of the results of the performance of participants of the regional stage of the All-Russian Olympiad of schoolchildren on the subject of "Physical culture"
Authors:   Novosibirsk State Pedagogical University, Trifonov Evgeny Yurievich
Published: December 2021

The introduction presents the structure of the All-Russian Olympiad for schoolchildren, its stages. Some difficulties in its organization and attitude towards it in comparison with other subject Olympiads are noted. The purpose of the article is to analyze the dynamics of the performance of participants in the regional stage of the All-Russian Olympiad for schoolchildren in the subject “Physical culture” in the Novosibirsk region from 2017 to 2021 in order to draw attention to the weaknesses in the performance and plan targeted preparation for the Olympiad, achieving results at the final stage. Materials and methods. In the period 2017-2021, on the basis of the Novosibirsk Pedagogical University, the regional stage of the All-Russian Olympiad for schoolchildren in the subject “Physical culture” was held. Observation, comparative analysis of the results of the performance of schoolchildren made it possible to reveal the presence of interest on the part of the younger generation of Russians in such a subject as “Physical culture”, as well as to reveal weaknesses in the organization and preparation for this event. Research results. Monitoring of the total number of schoolchildren, as well as the average score, which was shown in the theoretical, methodological and practical rounds among boys and girls, as expected, showed the interest and better preparation of boys in this subject. Conclusion. The materials of the article will help to plan targeted preparation for the All-Russian Olympiad in order to achieve high results in the final stage of the Olympiad.
Giant Aortic Aneurysm in Child with Cutis Laxa Syndrome: Unusual Presentation, New Surgical Technique
Authors: Shamsaldeen Faden Mazen , Ahmed Noaman Nada , Osman Osama Osman Osama , Elassal Ahmed Abdelrahman , Al-ghamdi Arwa Mohammed , Debis Ragab
Published: December 2021

Ascending thoracic aortic aneurysms are rare in childhood and typically are seen in the setting of connective tissue defect syndromes. These aneurysms may lead to rupture, dissection, or valvular insufficiency, so root replacement is recommended. Here, we present a 17-month-old girl who presented with fever, cough, and pericardial effusion. Initially, we suspected this could be a COVID-19 case, so a nasopharyngeal swap was performed. An ascending aorta aneurysm involving the aortic arch was confirmed by echo, and urgent ascending aorta and arch replacement were done by utilizing the descending aorta as a new arch. The final diagnosis came with cutis laxa syndrome. In similar cases, good outcomes can be achieved with accurate diagnosis and appropriate surgical management.
Fibrin Sealant Patch for the Management of Intractable Bleeding From an LVAD Apex Cannula
Authors: Penov Kiril , Radakovic Dejan , Karimli Seymur , Aleksic Ivan
Published: December 2021

Background: Intractable bleeding from the apical cannulation site of a left ventricular assist device (LVAD) is a dreaded complication.
Case report: A 52-year-old male suffering from dilative cardiomyopathy (DCM) with fixed pulmonary hypertension underwent reoperative LVAD implantation after previous mitral valve surgery. The patient underwent three rethoracotomies for bleeding from the apex cannulation site without achieving hemostasis. Conventional techniques and application of fibrin sealants and polymeric sealing devices did not fix the problem. The bleeding stopped after application of the EVARREST® Fibrin Sealant Patch (FSP), and he needed no further transfusions.
Conclusion: This patch might become a useful tool for intractable bleeding problems in LVAD surgery.
Modified Mini-Maze for Atrial Fibrillation with Interruption of Inferior Vena Cava
Authors: Xu Bijun , He Fan , Wang Shiqiang , Chen Huaidong , Zhang Weimin
Published: December 2021

A 57-year-old female with paroxysmal atrial fibrillation and an interrupted inferior vena cava (IVC) was referred to our hospital for radiofrequency ablation. Transseptal puncture and left atrium ablation failed through a standard IVC approach via the femoral vein due to intrahepatic interruption of IVC. We performed a modified mini-maze procedure in this patient through the left thoracic cavity under video-assisted thoracoscopic surgery (VATS). We can successfully complete pulmonary vein (PV) isolation, left atrium box isolation, cardiac ganglia ablation, Marshall ligament ablation, and coronary sinus epicardium ablation using this technique.
The Self-Inflicted Multiple Organs Injury with Nail Gun
Authors: Fang Xiaorong , Yu Changjiang , He Fan
Published: December 2021

We report the case of a patient with injuries to multiple organs as a result of attempted suicide with a nail gun. The patient shot 12 nails into his chest, causing damage to multiple organs, including the heart, lungs, and stomach. With timely emergency surgery, we successfully removed all the nails, and the patient was discharged from the hospital two weeks after surgery.
Electronic structure and Thermoelectric Properties of Hybrid Organic-Inorganic Perovskites [NH3-(CH2)3-COOH]2CdCl4
Authors: Ouaaka Elmustafa , Kassou Said , Ettakni Mahmoud , Sayouri Salaheddine , Khmou Ahmed , Khechoubi El Mostafa
Published: December 2021

In this work, we conducted the first principle calculation of electronic structure and transport properties of [NH3-(CH2)3-COOH]2CdCl4 (Acid-Cd). The generalized gradient approximation is used in structural optimization and electronic structure. The theoretical band gap value found is in good agreement with experimental. Electronic thermal conductivity, electrical conductivity, Seebeck coefficient (S) and figure of merit (ZT) have been calculated using semi-local Boltzmann theory to predict the thermoelectric characteristic of the studied materials.
The Way of the Increasing Two Times the Efficiency of Silicon Solar Cell
Authors: Gulomov Jasurbek , Aliev Rayimjon
Published: December 2021

Increase of the efficiency of the solar cells which are produced in industry, is important. Increase of efficiency of solar cells was identified, when nanoplasmonics phenomenon was formed in solar cell. So, in this article, influence of nanoparticles Pt, Au, Ag and Cu on properties of silicon based solar cell has been studied. When nanoparticle Pt was inclused in silicon based solar cell, its efficiency increased 2.31 times. Optimal radius of nanoparticule Pt was identified to be between 15-25 nm.
Reduction of drug-drug interaction and inappropriate prescription in polymedicated elderly who consult in the ambulatory
Authors: A Fajreldines
Published: December 2021

Introduction: Older adults or elderly people over 64 years of age are patients more vulnerable to suffering adverse events related to medication, and this can generate states of both physical and psychological discomfort, loss of autonomy, mental disorders, etc. Objectives: To analyze the drug-drug interaction and inappropriate prescription of drugs in the outpatient setting in the elderly and implement barriers to reduce this problem. Materials and methods: Quasi-experimental study, of the before after type. The Beers 2019 criteria were used to assess inappropriate drug prescribing. The Uptodate definition of drug-drug interactions and their classification were used. Results: 203 polypathological, sarcopenic elderly patients were studied. These patients attended the outpatient consultation during the 2016-2018 period. 99 patients participated in the pre-intervention and 104 in the post-intervention. The distribution by sex was: 110 (54.2%) women and 93 (45.8%) men. The mean age was 77.3 + 13.3 years. In the total sample analyzed before the intervention, 33 (33.3%) showed inappropriate prescription of drugs criteria. Drug interactions in the pre-intervention were present in 51 patients (51.5%). After the intervention that consisted of training doctors with the Beers criteria and editing a list with clinically relevant interactions in the elderly, which can cause adverse events, inappropriate prescription was reduced to 26 patients (25%), p = 0.05, and clinically relevant interactions were reduced from 51 (51.51%) to 12 (11.53%), p = 0.003. The association between inappropriate prescription and clinically relevant interactions is OR: 3.23 (95% CI 1.91-3.88). Conclusions: The proportion of patients with inappropriate prescription is within the ranges published by various authors as well as drug interactions, the intervention was good to reduce the two problems in this sample of patients.
Osteoarthritis and fear
Authors: Marks Ray
Published: December 2021

Osteoarthritis, a largely intractable health condition with incalculable health and financial and social costs and ramifications among many older adults remains an essentially intractable condition. Commonly instructed to exercise to combat pain, the role of fear is seldom discussed as an enormously influential exercise impediment in this regard. This mini review highlights aspects of the research that imply consideration of fears rather than exercise prescription alone may be more helpful than not in efforts to allay the enormous suffering experienced by most older adults diagnosed as having osteoarthritis of one or more joints.
Underutilized horse chestnut (Aesculus indica) flour and its utilization for the development of gluten-free pasta
Authors: Insha Rafiq Syed , Muzaffar Khalid , Mansha Rafiq Syed , Saxena DC , Dar BN
Published: December 2021

There has been a growing demand for the production of gluten-free products due to increased occurrence of celiac disease. Thus, different research groups have been investigating the use of various available materials for the development of these functional products to fulfill customer’s needs. Horse Chestnut (Aesculus indica) seeds are underutilized, low-cost, and gluten-free, found in hilly areas of the Himalayan region of Kashmir valley, India. To determine their potential as an alternative to conventional food grains, an investigation was conducted to determine the physicochemical, functional, pasting, and thermal properties of Horse Chestnut (HCN) flour and its compatibility for the development of gluten-free pasta. HCN flour comprised 73.34% carbohydrate, 11.36% protein, 6.34% crude fiber, 3.27% fat, 3.16% ash, 3.15g/g oil absorption capacity, and 4.65% water absorption index. HCN flour showed 505 cp peak, 354 cp trough, 151 cp breakdown, 472 cp final viscosity, and 66.05°C pasting temperature. Transition temperatures (onset, peak, and conclusion) and enthalpy change (ΔH) were 60.12°C, 69.90°C, 81.53°C, and 10.56 J/g, respectively. Pasta prepared from HCN flour using guar gum (0, 0.5, and 1%) was analyzed for color, cooking qualities, and textural and sensory analysis. The present results showed that HCN flour possesses good nutritional quality and has properties comparable to conventional wheat flour. Therefore, HCN-flour-based pasta can act as a nutritious alternative to conventional gluten-free pasta and add variety to the diet of people suffering from celiac disease.
INVESTIGATING CROSS CONGRUENCE BETWEEN BUTTERFLY TAXA AND ECOLOGICAL COMMUNITY WITHIN THE FRAMEWORK OF SYSTEMATIC CONSERVATION PLANNING: A CASE STUDY FROM LESSER CAUCASUS ECOREGION OF TURKEY
Authors: Kaya özdemirel Banu
Published: December 2021

Cross taxa congruence was investigated between butterfly taxa and ecological community for fine spatial scale (10 × 10 km² UTM grids) in north-eastern part of Turkey. The study area was evaluated within the scope of systematic conservation planning, and analyses were performed for sets of priority protected areas composed using complementarity-based site selection software Marxan. Cross taxa congruence was subsequently examined both in species richness and ecologic complementarity. Accordingly, it has been observed that the cross-taxon congruence between butterfly taxa and ecological community was relatively better than the results of previous studies. Another remarkable finding is that ecological community was a more robust surrogate than butterfly taxa. Although the results are valuable for conservation studies, they highlight the fact that a simple surrogate-based site selection would be inadequate to represent overall biodiversity.  The weakness of congruence patterns among surrogates would also lead to gaps in biodiversity conservation. These findings therefore draw attention to the necessities of incorporating surrogates of distinct ecology or some other surrogates like environmental parameters into conservation planning. Otherwise, there may be mistakes regarding species representation and the vast majority of species may be misrepresented in protected areas and protected area plans. At this point, it should be emphasized that understating cross taxa congruence and/or relationships is a key component for efficient biodiversity conservation.
LIFE HISTORY STAGES of THREE UNIVERSITIES GRADUATE (To the 100th anniversary birth of the Academician N.N. Yanenko)
Authors:   Tomsk State University (Tomsk, Russian Federation), Bertsun V.N. , Kosova E.S. ,   Tomsk State University (Tomsk, Russian Federation)
Published: December 2021

The article presents the main stages of scientific activity of an outstanding Soviet mathematician and mechanic, Academician Nikolai Nikolaevich Yanenko, graduate of the Faculty of Mechanics and Mathematics of Tomsk University, Honored Activist of Socialist Labor, winner of three USSR State Prizes.
ROTATIONS OF TORI IN A LIQUID CRYSTAL STRUCTURE
Authors:   Tomsk State University (Tomsk, Russian Federation), Bubenchikov A.M. , Bubenchikov M.A ,   Tomsk State University (Tomsk, Russian Federation), Mamontov D.V. ,   Tomsk State University (Tomsk, Russian Federation), Kaparulin D.S. ,   Tomsk State University (Tomsk, Russian Federation), Lun-Fu A.V. ,   OOO Gazprom Transgaz Tomsk
Published: December 2021

Liquid crystals are a collection of flattened molecules. On the one hand, they have a welldefined structure, on the other hand, this structure is deformable, since its elements can change their position in space. In columnar structures, consisting of disks, plates, and tori, the fluid lines and cords are distinguished. In the case of tori and circular disks, a hexagonal structure of the arrangement of molecules is observed in a combination of the cord. The aim of this work is to obtain the stability of tori positions in an elementary fragment of a liquid crystal and to analyze their rotations in a self-consistent field of the surrounding toroidal molecules. To solve this problem, the method of mathematical modeling was used, based on classical models of molecular dynamics. The calculation is carried out on the basis of the model of cross-atom-atom interactions for molecular tori. The minimal fragment of the cord is selected, which makes it possible to determine the characteristic dynamic state of the central torus in the fragment. To describe the motion of the molecular tori, the equations of motion for their centers of mass and the Euler equations for their angular displacements are used. The minimal fragment of the material contains twenty-nine tori. The equations for displacements of the centers of mass of the tori are initially represented as ordinary differential equations of the second order. However, by introducing fictitious points into the consideration of velocities, they can be reduced to a system of first-order equations with a doubled number of lower-order equations. The resulting system of the first-order differential equations is integrated numerically using a highorder accuracy step-by-step scheme. All calculations are performed with a constant time step. The accuracy of the obtained numerical results is verified in terms of the balance of total energy of the system. Calculations show that the central torus of the presented fragment executes angular oscillations around its main axis with amplitude of more than one revolution. Thus, the performed calculations show that a representative fragment of the liquid crystal structure of molecular tori can be used as a generator of high-frequency mechanical vibrations.
ALLOWANCE FOR THE EFFECT OF CONDENSED PARTICLES ON BALLISTIC PARAMETERS OF A SHOT
Authors:   Tomsk State University (Tomsk, Russian Federation), Burakov V.A. , D'yachkovskiy A.S. ,   Tomsk State University (Tomsk, Russian Federation), Ishchenko A.N. ,   Tomsk State University (Tomsk, Russian Federation), Kasimov V.Z. ,   Tomsk State University (Tomsk, Russian Federation), Rogaev K.S. ,   Tomsk State University (Tomsk, Russian Federation), Samorokova N.M. ,   Tomsk State University (Tomsk, Russian Federation)
Published: December 2021

A mathematical model of the shot fired from a powder propellant setup is developed. An arbitrary number of powder particles of various types are supposed to be in a propellant charge, which are different in size, shape, energy characteristics, and layer-by-layer burning velocity. The products of their combustion represent a mixture of non-viscous non-heat conductive gases with known equations of state. These gases are generated during combustion of the powder particle of a corresponding type. Some condensed particles may occur in the mixture of combustion products during the burning of powder particles. The motion of the polydispersed mixture of combustion products along a varying-cross-section channel is described by the laws of conservation of mass, momentum, and energy. When formulating these laws, the mass, momentum, and energy exchange between gas and condensed phases is taken into account. The formulation is universal and allows one to use the laws for modelling a wide range of internal ballistic phenomena. In this paper, a theoretical parametric research is shown as an example, which is aimed at estimating the effect of quantity of the occurring condensed particles on basic ballistic characteristics of a shot.
ON THE VARYING BRACHISTOCHRONE SHAPE WITH ALLOWANCE FOR CHUTE LOADING LIMITATION
Authors:   Moscow Aviation Institute, Gladkov S.O. , Bogdanova S.B. ,   Moscow Aviation Institute
Published: December 2021

first time. Here, the dynamic equations for the motion of the material body rolling down the chute are formulated neglecting the friction forces. It is shown that if the stress limit for the chute material is taken into account, the shape of the chute varies greatly as a function of the parameter. Four possible cases are analyzed when the parameter is: equal to zero, more than unity, less than unity, and equal to unity. It is found that if the parameter is more than unity, the chute shape represents almost horizontal and vertical segments of a trajectory, which is clear from a physical point of view, since for this type of the trajectory the chute is least affected by the body moving along. If the parameter is equal to unity, the chute takes a specific loop-like shape. If the parameter is equal to zero, the system of equations describes a classical brachistochrone. The solution to the problem is applicable in practice for predicting the shape of the chute withstanding high loads when the stress limit for the material is known.
[RETRACTED] Best Health Keto Amanda Holden UK Reviews v1
Authors: Health Keto UK Best
Published: December 2021

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Authors: not provided vikkisinghhh
Published: December 2021

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[RETRACTED] Veromin CBD Gummies United Kingdom v1
Authors: not provided Ukveromincbdgummies
Published: December 2021

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BrADseq for DNA v1
Authors: Thomas Kelly S. , not provided tsuneo.hakoyama , Kumaishi Kie , Okuda-Yabukami Haruka , Kato Sachi , Hayashi Makoto , Minoda Aki , Ichihashi Yasunori
Published: December 2021

The amount of input DNA available to prepare next-generation sequencing (NGS) libraries is often limited, which can lead to GC content bias and enrichment of specific genomic regions with currently available protocols. In this study, we used breath capture technology to incorporate sequencing adapters into DNA to develop a novel cost-effective protocol for the preparation of genomic DNA libraries. We performed a benchmarking experiment comparing our protocol with common commercially available kits for genomic DNA library preparation with input DNA amount in the range of 1 to 50 ng. Our protocol can generate high-quality genomic sequence data with a marked improvement in coverage breadth and low GC bias, in contrast to standard protocols. Further, our protocol reduces sample handling time and reagent costs, and requires comparatively fewer enzymatic steps relative to other protocols, making it suitable for a range of genomics applications.
JORNAL O PIRACAIENSE UM RESGATE HISTÓRICO DE CEM ANOS
Authors: Gradiz Ana Catharina , Tosin Giuliano , Dias Osni
Published: December 2021

Resultado de uma pesquisa de iniciação científica desenvolvida no Centro de Estudos, Pesquisas e Extensão (CEPE) da UNIFAAT. Este trabalho aborda o jornal “O Piracaiense”, que existiu no século passado, na cidade de Piracaia. Apresenta uma contextualização histórica da cidade e do próprio veículo de imprensa nas primeiras décadas do século XX, período dos exemplares sobre os quais se concentra o presente estudo. Além da descrição do conteúdo do jornal, que retrata o cotidiano da cidade na época, este artigo propõe um resgate da memória coletiva local, preservando e valorizando a história regional através do patrimônio cultural jornalístico.
OS DESAFIOS DA PRÁTICA DOCENTE NA APLICAÇÃO DA LEI 10.639/03 NOS 4º E 5º ANOS DO ENSINO FUNDAMENTAL I NAS ESCOLAS MUNICIPAIS DE PIRACAIA/SP
Authors: Moreira Ana Carolina Saviolo , Maioli Cátia Grassetti , Pinto Andréa Alves , Nishimura Pryscilla Karla M. Oliveira
Published: December 2021

Este trabalho é resultado de uma pesquisa que abordou a obrigatoriedade do ensino da história e cultura afro-brasileira e africana na Educação Básica brasileira (Lei 10.639/03), tendo procurado identificar desafios que dificultam a aplicação dessa legislação. Utilizou-se de análise focada em documentos escolares (Projeto Político Pedagógico e Plano de Gestão), assim como da aplicação de questionário aos professores e gestores de escolas que atendem estudantes de 4º e 5º anos do Ensino Fundamental da rede municipal da cidade de Piracaia – SP. Procurou-se observar em que medida as escolas conseguem realizar a transposição didática da lei em salas de aula e no cotidiano escolar de modo geral, sendo que, ao final, verificou-se que a aplicação da lei demonstra ser insuficiente, tendo sido apurado que dentre os principais problemas estão, de um lado, a não presença de temáticas relacionadas a história e cultura afro-brasileira nos documentos que orientam a gestão da escola e, de outro, o fato de a maioria dos professores declararem que não conhecem a lei e que não se sentem preparados para aplicá-la adequadamente.
TÜRKİYE’DE GEOMETRİK DÜŞÜNME ÜZERİNE YAPILAN ARAŞTIRMALARA İLİŞKİN BİR META-SENTEZ
Authors: Saraçoğlu Mehtap , Aşılıoğlu Bayram
Published: December 2021

Bu araştırmanın amacı, Türkiye’de ilköğretim, ortaöğretim ve lisans öğrencilerinin geometrik anlama seviyelerinin mevcut durumunu, yapılan araştırma sonuçlarından yola çıkarak, meta-sentez yöntemi ile ortaya koymaktır. Bu araştırmada 1999-2014 yılları arasında Türkiye’de tüm öğretim kademelerinde “Van Hiele Geometrik Düşünme Düzey Belirleme Testi” içeren, dahil edilme ve hariç tutulma işlemleri çerçevesinde bu meta-sentez çalışmanın amacına hizmet edebilecek, nitel veya nicel araştırma yöntemlerini kullanarak hazırlanmış 36 yüksek lisans ve doktora tezi, 20 bilimsel makale araştırma kapsamına alınmıştır. Çalışmada ele alınan tüm örneklemlerdeki öğrencilerin Van Hiele geometrik düşünme düzeylerinin oldukça düşük seviyede olduğu görülmektedir. İlköğretim, ortaöğretim ve lisans öğrencilerinin sahip olmaları gereken geometrik düşünme düzeylerine ulaşamadıkları tespit edilmiştir. Farklı öğretim kademeleri ve yaş grupları üzerinde yapılan çalışma bulguları, öğrencilerin geometri düşünme düzeylerinin yaşa veya olgunlaşmaya bağlı olmayabileceğini, daha çok geometri deneyimlerine bağlı olabileceğini göstermektedir.
Propranolol significantly reduced DNA polymerase β expression in patients with essential tremor
Authors: Kandemir Nefise , Kenanoglu Sercan , Gultekin Murat , Gokce Nuriye , Akalin Hilal , Taşçıoğlu Nazife , Mirza Meral , Koseoglu Emel , Dundar Munis
Published: December 2021

Background Essential tremor (ET) is the most common movement disorder. Propranolol is a first-line medication for ET. We aimed to evaluate the effect of propranolol on the expression of poly (ADP-ribose) polymerase 1 (PARP1) and DNA polymerase beta (POLB) genes, which are known to be related to neurodegenerative diseases, in patients with ET.
MethodsThirty-five healthy volunteers and thirty-five patients followed up with essential tremors were included in a non-randomized control experimental study. Expressions of PARP1 and POLB genes were compared between the control group and the patient group. In addition, pre- and post-treatment gene expression levels and Fahn-Tolosa-Marin tremor scale values of the patient group were compared after 8 weeks of propranolol treatment. The Wilcoxon rank and Mann Whitney U tests were used to analyze the data.
ResultsAt baseline, PARP1 expression was significantly lower in the ET group than in the control group. (p<0.001). POLB gene expression was significantly higher in the pre-treatment ET group than in the controls (p<0.05). There was no significant difference in PARP1 expression levels before and after 8 weeks of propranolol treatment. POLB gene expression was significantly higher in the pre-treatment group than in the post-treatment group (p<0.001).
ConclusionPropranolol significantly decreased POLB gene expression but there was no significant difference in PARP1 gene expression levels in the patient group, after 8 weeks of propranolol treatment.
Detection of immunogenic protein from salivary gland of Aedes albopictus
Authors: Oktarianti Rike , Khasanah Rochmatul Nuryu , Wathon Syubbanul , Senjarini Kartika
Published: December 2021

BackgroundDengue virus is transmitted by several species of Aedes mosquitoes, with Aedes albopictus as secondary vector. During blood feeding, these vectors inject saliva into the vertebrate hosts. The saliva contains anticoagulant, anti-inflammatory and immunogenic factors. The objective of this research was to detect immunogenic proteins from Ae.albopictus salivary glands reacting with sera of people living in dengue endemic areas.
MethodsThe identification of immunogenic proteins of Ae. albopictus salivary gland used one-dimensional gel electrophoresis (sodium dodecyl sulfate polyacrylamide gel electrophoresis), and western blot analysis, respectively. To determine the immunogenic nature of the candidate proteins, the antigens from the salivary gland of Ae. albopictus were reacted with sera from healthy persons, dengue hemorrhagic fever (DHF) patients, and neonates, each of the groups comprising 10 samples.
ResultsThe protein profiles of Ae. albopictus salivary glands showed 13 bands with molecular weights from 16 kDa up to 97 kDa, i.e. 16, 17, 26, 28, 31, 32, 45, 55, 60, 67, 73, 76, and 97 kDa. According to western blot analysis result, the 31 kDa proteins were recognized in all endemic population sera, both in DHF patients and healthy persons. In contrast, protein bands of 47 and 67 kDa were only recognized by the sera of DHF patients.
ConclusionThree immunogenic proteins of 31, 47 and 67 kDa were detected from Ae. albopictus salivary glands. These immunogenic proteins may be developed as candidate biomarkers for bite exposure to Ae. albopictus and as vector-based DHF vaccines.
Viral load as a risk factor of reverse transcriptase inhibitor drug resistance mutation in antiretroviral-treated people living with HIV/AIDS
Authors: Hutapea Hotma Martogi Lorensi , Kridaningsih Tri Nury , Prasetyo Khoirul Huda , Antwi Milton Boaheng
Published: December 2021

Background The human immunodeficiency virus type 1 (HIV-1) is a major contagion faced by the population of Indonesia. The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). The aim of this study was to determine the association between CD4 count, CD4 count changes, viral load, adherence to therapy, and therapy history in the presence of DRM in people living with HIV/AIDS (PLWHA).
MethodsThis was a cross-sectional study involving 269 adults who underwent antiretroviral (ARV) therapy for at least 6 months. The frequencies of DRM and polymorphisms were measured by partial amplification of the reverse transcriptase (RT) gene using RT-nested PCR on samples with viral loads of >1000 copies/mL. Sequencing was performed using the Sanger method, and edited by BioEdit. The edited sequences were submitted to http://hivdb.stanford.edu for DRM determination. Respondents’ medical data, CD4 count, viral load, and DRM were analyzed by simple and multiple logistic regression.
ResultsThe multiple logistic regression analysis showed a significant association of CD4 count (aOR=12.47; 95% CI: 1.45 -107.39; p=0.023) and viral load at the time of study (aOR=29.56; 95% CI: 3.47-251.52; p=0.002) with the presence of DRM in respondents. ARV substitution history was not associated with the presence of DRM. There were 17 respondents (6.3%) carrying HIV-1 DRM, with M184V/I (11 sequences) as the most frequent pattern of NRTI resistance, and K103 (9 sequences) as that of NNRTI resistance.
ConclusionThis study demonstrated that viral load at the time of the study was the most influential determinant factor for the presence of DRM in PLWHA.
Applications of the Sub Equation Method for the High Dimensional Nonlinear Evolution Equation
Authors: DURAN Serbay , KAYA Doğan
Published: December 2021

In this article, Generalized (3+1)-dimensional Shallow Water-Like (SWL) equation is taken into consideration and exact solutions have been constructed of the SWL equation using sub equation method. This method is an easier and efficient method for finding analytic solutions of nPDEs. The method appears to be easier and faster for symbolic computation. Moreover 2D, 3D and contour graphical representation of the obtained results of the specified equation is made using ready-made package program for certain values and thus the conformity of the founded results has been demonstrated.
Daily Flow Modeling With Random Forest and K-Nearest Neighbor Methods
Authors: DALKILIÇ Hüseyin Yildirim , YEŞİLYURT Sefa Nur , SAMUİ Pijush
Published: December 2021

Water is an indispensable natural resource for living life. Therefore, protection and control of water resources are of great importance. Since river flow estimation and modeling are very important in cases such as the management of water resources, irrigation, it is included in the literature as an issue that needs constant research and development. A large number of techniques are being used for estimation and modeling; thus, the estimation results are gradually improving with the development of the studies carried out, the comparison of techniques, and the determination and removal of the shortcomings. In this study, Random Forest and K-Nearest Neighbors nonlinear regression models, which are two of the machine learning methods, were used to evaluating the estimation results, to find the better estimation method, and to determine the advantages and disadvantages of these methods. In addition, Random Search and Grid Search methods were used to make the hyperparameter selection and comparison for the Random Forest model. In this study, in which daily flow data of 1981-2011 of the two stations in the Euphrates were used, and, when compared to other models, it was observed that better results were obtained when Random Search was applied to determine the hyperparameters of the Random Forest model.
Notes on Recent Achievements in Proving Stability using KeYmaeraX
Authors: Baar Thomas , Schulte Horst
Published: December 2021

KeYmaeraX is a Hoare-style theorem prover for hybrid systems. A hybrid system can be seen as an aggregation of both discrete and continuous variables, whose values can change abruptly or continuously, respectively. KeYmaeraX supports only variables having the primitive type bool or real. Due to the mixture of discrete and continuous system elements, one promising application area for KeYmaeraX are closed-loop control systems. A closed-loop control system consists of a plant and a controller. While the plant is basically an aggregation of continuous variables whose values change over time accordingly to physical laws, the controller can be seen as an algorithm formulated in a classical programming language. In this paper, we review some recent extensions of the proof calculus applied by KeYmaeraX that make formal proofs on the stability of dynamic systems more feasible. Based on an example, we first introduce to the topic and prove asymptotic stability of a given system in a hand-written mathematical style. This approach is then compared with a formal encoding of the problem and a formal proof established in KeYmaeraX. We also discuss open problems such as the formalization of asymptotic stability.
Medical Sciences’ Students Responses During the Late Phase of the COVID-19 Pandemic in Iran: A Comprehensive Investigation of the Risk Perception and Information Exposure
Authors: Shafie Mahan , Mayeli Mahsa , Hosseini Hamed , Ashoorkhani Mahnaz
Published: December 2021

COVID-19 pandemic obligated applying population-level behavioral modifications to effectively prevent the spread of the disease. This necessitated investigating those measures that determine population behavior. Herein we have studied risk perception and information exposure that are among those determinants in Iran. 402 cases from medical sciences students were enrolled during the last week of September 2020. Using an online questionnaire, risk perception and sources of information about COVID-19 were investigated. Although most students considered COVID-19 preventable, merely a few considered the disease curable. A higher risk was perceived concerning the families compared to themselves. Moreover, most of them believed the prognosis good even in high-risk patients. Social media was the most informative source used; however, health professionals were considered the most reliable. The risk perception was equal between those diagnosed with COVID-19 or had a family member diagnosed compared to those without such exposure in most questions. Also, no significant difference was observed in risk perception between those students with serious underlying medical conditions and those without one regarding most items. Lastly, major and grade were the most significant demographic contributors to the risk perception. Moderate risk was perceived overall among the cases in which major and grade were the only remarkable demographic contributors. Unexpectedly, underlying medical history was not significantly correlated with the perceived risk. Lastly, previous COVID-19 exposure merely altered the curability and preventability perception.
Comparison of the Prophylactic Effect of Propofol, Dexamethasone and Ondansetron on Post-Operative Nausea and Vomiting in Elective Cesarean Section Under Spinal Anesthesia
Authors: Hassani Ebrahim , Karami Nazli , Hassani Asma , Hassani Leila , Ashraf Veghar
Published: December 2021

Nausea, and vomiting are common complications in women undergoing cesarean section with spinal anesthesia. This study aimed to compare the propofol, dexamethasone, and ondansetron effects on nausea and vomiting. In this double-blind, randomized clinical trial study, 120 women aged 15 to 35 years candidates for cesarean section under spinal anesthesia were enrolled. Patients were randomly divided into four groups (three-drug groups and control group). Patients received 0.05 mg/kg ondansetron (group O), 0.1 mg/kg dexamethasone (group D), 0.2 mg/kg propofol (group P) and normal saline in controls (group C). Nausea and vomiting in recovery and 6 hours after surgery compared between groups. In recovery and 6 hours after surgery, both nausea and vomiting were the highest in group C while they were lowest in group O. the frequency of nausea was 11(36.7%) in both recovery and 6 hours after surgery, and the frequency of vomiting was 12(40%) and 10(33.3%) in the recovery and 6 hours after surgery respectively. Among three drug groups, nausea and vomiting were higher in group D in both the recovery room and 6 hours after surgery. The frequency of vomiting was 10 (33.3%) and 5 (16.7%) in recovery and 6 hours after surgery in group D, respectively. These differences were statistically significant between the four groups (P<0.05). The preventive effect of dexamethasone is not very useful in both periods. Therefore, it can be recommended that in the short period after surgery, propofol has a beneficial effect in preventing postoperative nausea and vomiting.
Sexual Dysfunction in Postmenopausal Women
Authors: Karimi Fateme Zahra , Pourali Leila , Hasanzadeh Elahe , Nosrati Hadiabad Seyede Fateme , Pouresmaeili Nasim , Abdollahi Mahbubeh
Published: December 2021

Nowadays, women have a longer menopausal duration due to the worldwide dramatic life expectancy increase. Sexual dysfunction is one of the most prevalent problems during menopause that affect women`s quality of life, mental health, and interpersonal relationship. This study aimed to investigate sexual dysfunction and its contributing factors amongst married postmenopausal women. This cross-sectional study was conducted among 164 postmenopausal women who attended the menopause clinic of the academic hospitals in Mashhad during 2017-2018. Data were collected using a checklist that included demographic and reproductive information and the validated Persian version of the Female Sexual Function Index questionnaire (FSFI). The mean age of participants was 53.55±6.25 years. The mean FSFI score was 20.06±6.66, and 65.2% of women had sexual dysfunction. The most disturbed sexual domains were; desire (86%, n: 141), arousal (82.3%, n: 135), lubrication (71.3%, n: 117) and sexual satisfaction (70.1%, n: 115), respectively. The partner`s age (P=0.01), time since menopause onset (P=0.01), age at marriage (P=0.02), and frequency of sexual intercourse (P˂0.0001) had a significant relationship with sexual function. The sexual function of postmenopausal women in this study was highly deteriorated. The associated factors were; older age of the spouse, younger age at marriage, longer time since menopause onset, and lower frequency of sexual intercourse. It is important to determine perimenopausal women who are at potential risk of sexual dysfunction and consult them for preventive programs and strategies.
The Effect of Circuit Resistance Training With Varying Intensity on Selected Inflammatory Markers in Obese Men
Authors: Emamdoost Saeid , Abbassi Daloii Asieh , Barari Alireza , Saeidi Ayoub
Published: December 2021

Obesity and associated chronic inflammation lead to insulin resistance. The aim of this study was to evaluate the effect of varying intensity circuit resistance training on metabolic and inflammatory markers in obese men. In a semi-experimental trial, 44 obese men were selected and randomly divided into four groups, including 1) Control (n=11), 2) Low-intensity circuit resistance training (n=11), 3) Moderate-intensity circuit resistance training (n=11), and 4) High-intensity circuit resistance training (n=11). Resistance training was performed at different intensities, including 1) High-intensity circuit resistance training (80% 1RM), 2) Moderate-intensity circuit resistance (60% 1RM), and 3) Low-intensity circuit resistance training (40% 1RM), three sessions per week for 12 weeks. Serum levels of Dectin-1, TLR2, TLR4, MyD88 were measured using an ELISA kit. Data were analyzed with covariance analysis at P<0.05. Twelve weeks of moderate and high-intensity circuit resistance training significantly reduced weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR (P=0.001). The reduction of weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR were significant in obese men in the high-intensity training group compared to low-intensity training (P=0.001). It seems that circuit resistance training, especially high-intensity circuit resistance training, can be used as an option to reduce the inflammatory and metabolic complications associated with obesity.
Daytime Hypersomnolence in COVID-19: A Case Report and Literature Review
Authors: Shabani Mahya , Rahimi Besharat , Mehrabi Nejad Mohammad Mehdi , Erfanian Reza , Najafi Arezu
Published: December 2021

Coronavirus infectious disease 2019 (COVID-19) is confirmed to develop neurocognitive complications. In the present paper, we describe two patients with laboratory-confirmed COVID-19 and excessive daytime sleepiness. In the present study, we reported two laboratory-confirmed cases of COVID-19 with excessive daytime sleepiness. Patients had drowsiness and mild confusion on presentation. In both cases, CNS infections, including meningitis and encephalitis, were ruled out. Both patients’ symptoms remarkably improved following the therapeutic course indicating the direct effect of SARS-CoV2 in sleep modulating centers on the brain. COVID-19 should be considered in patients with excessive daytime sleepiness and drowsiness in the current outbreak.
Evaluation of Professors’ Satisfaction with a Short-Term Course of Medical Education in Birjand University of Medical Sciences During the COVID-19 Pandemic
Authors: Akbari Narjes , Abedi Farshid , Shahabinia Zahra , Mohammady Yahya , Zarei Afagh , Ramazanzade Khaironnesa , Sadr Ehsan , Salehiniya Hamid
Published: December 2021

Background: The aim of this study was to investigate the satisfaction of professors with the short-term course of medical education at Birjand University of Medical Sciences during the COVID-19 pandemic.
Methods: Initially, needs assessment was conducted for the content of the course; after determining the content, the course was held online through Adobe Connect system and offline through Navid system. Following completing the course, evaluation was performed, and finally, satisfaction with the course was assessed based on a 34-item questionnaire whose validity and reliability were established. In total, 44 participants in the course answered the questionnaire. The data were analyzed using t-test and correlation coefficient by SPSS, version 18.
Results: The mean age of the participants was 36.34 ± 5.64 years, and 56.8% (25 people) were female. In terms of academic rank, 75% were assistant professors. The average score of satisfaction was equal to 140.48, which indicates a high score of satisfaction with the course. In general, the score of satisfaction was higher than average in all fields. The average score of satisfaction in men was significantly lower than in women (P < 0.001). There was no significant relationship between satisfaction and degree, academic rank, age, and working experience (P > 0.05).
Conclusions: Professors’ satisfaction with the online and offline medical education courses in the relevant systems is at a high level. Thus, it is suggested that combined in-person and online empowerment courses should be held in the post-COVID-19 era.
COVID-19 Fear Association with Depression, Anxiety, and Insomnia: A National Web-Based Survey on the General Population
Authors: Akbarpour Samaneh , Nakhostin-Ansari Amin , Sadeghniiat Haghighi Khosro , Etesam Farnaz , Banafsheh Alemohammad Zahra , Aghajani Faezeh , Najafi Arezu
Published: December 2021

Objective: COVID-19 pandemic has influenced almost every country worldwide. Being in a pandemic situation can cause psychological distress to people, which can lead to sleep disorders. The present study aimed to assess prevalence of depression, anxiety, and insomnia among Iranian people and their relations with COVID-19 fear in the early stages of COVID-19 pandemic.
Method: A cross-sectional and population-based online study was designed. We created an online form and used Fear of COVID-19 scale (FCV-19), Generalized Anxiety Disorder 2 scale (GAD-2), Patient Health Questionnaire-2 (PHQ-2), and Insomnia Severity Index (ISI), to assess fear of COVID-19, anxiety, depression, and insomnia, respectively. We sent the link to the online survey to Iranians interested in participating in the study via social media, and 1223 Iranian completed the form.
Results: A total of 1223 individuals with a mean age of 39.82 ± 10.75 years participated in the study. Prevalence of insomnia, depression and anxiety among our participants were 55.2%, 61.5%, and 50.9%, respectively. The mean FCV-19 score among the participants was 19.70 ± 5.08. Insomnia was more common among those who were 50 years or older. Fear of COVID-19 was related to a more risk of progression toward depression, anxiety, and insomnia.
Conclusion: Fear of COVID-19 has a considerable association with depression, anxiety, and insomnia in the pandemic, and strategies to reasonably decrease people’s fears can help to reduce incidence of psychological issues during the pandemic.