bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative performance of regression and the Markov based approach in the prediction of the future condition of a water distribution pipe network amidst data scarce situations: a case study of Kampala water, Uganda
Authors: Sempewo Jotham Ivan , Kyokaali Lydia
Published: November 2019

Globally, water utilities are grappling with the challenge of predicting the condition of deteriorating pipe network infrastructure amidst financial constraints and data-scarce scenarios. As a result, new innovative approaches such as statistical regression and Markov-based approaches have been introduced to aid water distribution pipe renewal decision making. However, comparison of the performance of these models under limited data has not been undertaken so far. In addition, the models have been applied elsewhere, in different environments and data availability scenarios. This paper addresses therefore the mentioned research gap and compares the performance of statistical regression and Markov models in the prediction of a condition of a pipe in a developing country. In addition, the criticality analysis of a block is studied. The data used for assessment is from Kampala water, the largest area in the National Water and Sewerage Corporation, Uganda. The results show that 78.26% of the prediction of the regression model is accurate in comparison to 88.4% for the Markov model. This means that the Markov-based approach is more superior than a regression model in a data scarce scenario. The approach will go a long way in helping water utilities in development of water decision pipe renewal plan amidst a limited budget and in data scarce scenarios.
Globalización y pobreza: propulsores de las migraciones internacionales contemporáneas
Authors: Herrera-Llamas Jorge Antonio , Alvarado-De Lima José Alejandro , Herrera-Aguilar Liceth
Published: November 2019

En las postrimerías del siglo XX la pobreza y el desencanto en la promesa de un mundo mejor, inmerso en el paradigma de la globalización como resultado de los adelantos en las telecomunicaciones y en el transporte, estimularon los flujos migratorios nacionales, regionales e internacionales. En consecuencia, se aceleró el crecimiento de las ciudades sin ninguna planificación, desarrollándose una nueva forma de vida periurbana marcada por el encuentro de diferentes etnias y formas de vida diversas que definen las principales áreas metropolitanas del mundo. La presente investigación analiza los factores económicos y sociales que encarna la migración como resultados de la pobreza y de la globalización. Desde el punto de vista epistemológico, se utiliza el método analítico que permite examinar las diferentes variables y sus relaciones de asociación en un contexto global; la frustración en la modernidad y el funcionalismo tecnológico, como esperanza de progreso económico y social, se manifiestan en la brecha entre el mundo rico y el mundo pobre; el éxodo constituye una salida ante la fallida globalización que no dio/da los resultados esperados en materia de reducir la desigualdad en profundidad con mujeres mames, así como con organizaciones sociales e instituciones.
Caribe más que moderno-occidental
Authors: Martínez Dueñas William Andrés
Published: November 2019

Es difícil definir si la categoría Caribe, en su enfoque explícitamente político, pretende convocar las fuerzas de un heterogéneo grupo de comunidades imaginadas o si por el contrario proyecta homogeneizar, neutralizar y capturar la multiplicidad de identidades cambiantes e híbridas que comparten el Mar Caribe y las cuencas continentales que a él llegan. La estrategia geopolítica se articula con el (los) proceso(s) de construcción de identidad; estos procesos de identificación Caribe no escapan a la dialógica representacional nosotros/otros, cuya expresión más popular es la dicotomía Occidente/El Resto. Para el caso Caribe, estas dicotomías también son múltiples, por ejemplo para el caso colombiano se ha construido, quizá recientemente, la dicotomía Caribe/Andes que implica una constante discusión sobre dónde comienza y termina la una y la otra y quién es y no es Caribe, donde las dos representaciones son igualmente monolíticas y reduccionistas; pero si miramos fuera de Colombia encontramos la pareja Caribe/Atlántico Norte, donde Caribe puede ser entendido como una construcción de la imaginación de individuos del Atlántico Norte, que se naturalizó y produjo una modernidad alternativa aún por etnografíar y entender (Trouillot, 2011); así mismo en algunas versiones el Caribe se construye como el lugar idílico del eterno verano litoral (cf. Guerrón-Montero, 2011) en contraposición al paisaje urbano industrial. Por otro lado, en la ficción el Caribe es visto como el lugar de la aventura, habitado por salvajes y excluidos, en contraste con los espacios civilizados de los imperios del siglo XVI.
El mercado laboral en el Caribe y las desigualdades socio-laborales (1890-1930) Los trabajadores calificados de la UFCO y de la Northern Railway Company a las puertas de la crisis de 1929
Authors: Sánchez Lovell Adriana
Published: November 2019

En este escrito se hace referencia a las transformaciones en el mercado laboral en la Región Caribe de Costa Rica Costa Rica. El objetivo consiste en comprender cambios en la composición de la fuerza laboral y en las condiciones laborales, en lo que respecta a la producción agroexportadora así como a la construcción de infraestructura ferroviaria, en un periodo comprendido desde 1890 hasta 1930. Para establecer las conexiones, se discuten las relaciones comerciales entre Costa Rica, Panamá y Jamaica, las migraciones laborales entre las mismas, y las investigaciones sobre la United Fruit Company en Cuba, que además, son tomadas como referente comparativo. La bibliografía consultada, consiste en publicaciones relativas a la historia del trabajo de las multinacionales bananeras en Centroamérica y el Caribe ístmico e insultar. Las fuentes comprenden los Censos Nacionales de 1891 y 1927, así como el Fondo Northern, disponible en el Archivo Nacional de Costa Rica (ANCR).

Palabras Clave: historia del trabajo, mercado laboral, ferrocarriles, caribe.
Matemática y complejidad
Authors: Polanía Quiza Luis Arturo , Ovalle Cerquera Daniel Enrique , Cárdenas Lis Juan David
Published: November 2019

En este trabajo se presentan algunos elementos relacionados con el enfoque o filosofía de la complejidad y su integración con la matemática. Se describen las particularidades de los sistemas dinámicos no-lineales como sistemas complejos, hecho raíz de la noción de ver a las matemáticas como una disciplina unificadora de la ciencia: una disciplina transdisciplinar. Además, se entiende el Teorema de Incompletud de Kurt Gödel, como una de las más significativas razones que puede argumentar la insuficiencia teórica de la lógica clásica a partir de fundamentos matemáticos, ajustándose a la noción de indecidibilidad de Murray Gell-Man, y así, abrir las puertas a las lógicas no clásicas, en particular, a la lógica del tercero incluido como la lógica de la complejidad.

Palabras Clave: Complejidad; Transdisciplina; Sistemas Dinámicos no-lineales; Lógica No-Clásica; Indecidibilidad; Sistemas Complejos
Evaluaciones de impacto social. Los antropólogos en la elaboración de proyectos de la Comisión Federal de Electricidad en México
Authors: Silvia Salazar Patiño Janeth , Arriaga Ornelas José Luis
Published: November 2019

En México el servicio de energía eléctrica es prestado de manera casi-monopólica por la Comisión Federal de Electricidad (CFE), que es en una "empresa productiva del Estado" y presenta tendencias de crecimiento sostenidas, lo cual le lleva a emprender proyectos de infraestructura permanentemente. El nuevo marco normativo para realizar esos proyectos le obliga a realizar Evaluaciones de Impacto Social previas. En este trabajo se describe la inclusión de algunos antropólogos para colaborar en las primeras evaluaciones, se comparte la vivencia directa en algunos de ellos y se reflexiona sobre el tipo de rol que se le pide jugar. Se expone cómo se están llevando a cabo las evaluaciones y se ofrecen datos recabados durante proyectos de subestaciones y nuevas líneas de transmisión en la región de Silao, Guanajuato, en donde se documentó que la gente se resiste, ya sea por desconfianza o como estrategia para obtener la mejor ganancia. Finalmente se reflexiona sobre la posición del antropólogo, las limitaciones que ahora se le imponen en este tipo de estudios y las potencialidades que tendría como mediador y evaluador de los proyectos, sin soslayar la disyuntiva deontológica al colaborar en proyectos e influir en las decisiones que orienten las acciones planificadas de la CFE.

 

Palabras clave: Evaluación de impacto social; antropología; energía eléctrica; Comisión Federal de Electricidad.
Should we Try to Alleviate Immunosenescence and Inflammaging - Why, How and to What Extent?
Authors: Witkowski Jacek M. , Bryl Ewa , Fulop Tamas
Published: November 2019

With advancing age, immune responses of human beings to external pathogens, i.e., bacteria, viruses, fungi and parasites, and to internal pathogens - malignant neoplasm cells - become less effective. Two major features in the process of aging of the human immune system are immunosenescence and inflammaging. The immune systems of our predecessors co-evolved with pathogens, which led to the occurrence of effective immunity. However, the otherwise beneficial activity may pose problems to the organism of the host and so it has builtin brakes (regulatory immune cells) and - with age - it undergoes adaptations and modifications, examples of which are the mentioned inflammaging and immunosenescence. Here we describe the mechanisms that first created our immune systems, then the consequences of their changes associated with aging, and the mechanisms of inflammaging and immunosenescence. Finally, we discuss to what extent both processes are detrimental and to what extent they might be beneficial and propose some therapeutic approaches for their wise control.
In Vitro Investigation Demonstrates IGFR/VEGFR Receptor Cross Talk and Potential of Combined Inhibition in Pediatric Central Nervous System Atypical Teratoid Rhabdoid Tumors
Authors: Obaid Halah , Kannappan Sunand , Gupta Mehul , Ruan Yibing , Zhang Chunfen , Bose Pinaki , Narendran Aru
Published: November 2019

Background:

Atypical teratoid rhabdoid tumor of the central nervous system (CNS
ATRT) is a malignancy that commonly affects young children. The biological mechanisms contributing
to tumor aggressiveness and resistance to conventional therapies in ATRT are unknown. Previous
studies have shown the activity of insulin like growth factor-I receptor (IGF-1R) in ATRT tumor
specimens and cell lines. IGF-1R has been shown to cross-talk with other receptor tyrosine
kinases (RTKs) in a number of cancer types, leading to enhanced cell proliferation.

Objective:

This study aims to evaluate the role of IGF-1 receptor cross-talk in ATRT biology and the
potential for therapeutic targeting.

Methods:

Cell lines derived from CNS ATRT specimens were analyzed for IGF-1 mediated cell
proliferation. A comprehensive receptor tyrosine kinase (RTK) screen was conducted following
IGF-1 stimulation. Bioinformatic analysis of publicly available cancer growth inhibition data to
identify correlation between IC50 of a VEGFR inhibitor and IGF-1R expression.

Results:

Comprehensive RTK screen identified VEGFR-2 cross-activation following IGF-1 stimulation.
Bioinformatics analysis demonstrated a positive correlation between IC50 values of VEGFR
inhibitor Axitinib and IGF-1R expression, supporting the critical influence of IGF-1R in modulating
response to anti-angiogenic therapies.

Conclusion:

Overall, our data present a novel experimental framework to evaluate and utilize receptor
cross-talk mechanisms to select effective drugs and combinations for future therapeutic trials in
ATRT.
Herbal medicine: current progress, and challenges
Authors: Barkat Abul , Goyal Anjali , Harshita Abul , Pottoo Faheem Hyder , Beg Sarwar , Ahmad Farhan J
Published: November 2019

:

Phytomedicine or herbal medicines have played an important role in disease treatment because of high therapeutic potential and better patient compliance. Although the practice of phytomedicne greatly affected during the dawn of the scientific era, there is a revival of interest in its potential by late 20th century, especially in the search of new drugs. Herbal drugs and its derivatives represent more than 50% of entire drugs in modern healthcare system. Because of the low success rate and huge capital investment hinders the further application of phytomedicine in disease treatment. In recent time, an increase of interest in the herbal meidicine has been observed by pharmaceutical industry to search novel phytotherapeutics. In the search of new phytomedicine there are several challenges identified like-the reproducibility of pharmacological activity of herbal extracts, toxicity and adverse effects, adulteration and contamination, herb–drug interactions issues; poor scientific and regulatory standards. In this review, we illustrated a short overview on herbal medicine history, current clinical perspective, pharmaceutical and regulatory challenges as well as its clinical presence. Moreover, problems encountered in drug discovery from herbal resources and its possible solutions are described.
An LC-MS/MS Method for Determination of Triple Drugs Combination of Valsartan, Amlodipine and Hydrochlorothiazide in Human Plasma for Bioequivalence Study
Authors: Said Rana , Arafat Basel , Arafat Tawfiq , Mallah Eyad
Published: November 2019

Background:

Current guidelines for the treatment of hypertension recommend combination
therapy, which intends to control blood pressure and enhance cardiovascular protection.

Materials and Methods:

A sensitive, reliable and selective tandem mass spectrometry (LC-MS/MS)
method has been developed for simultaneous quantification of amlodipine (AML), valsartan (VAL)
and hydrochlorothiazide (HCTZ) in human plasma. The chromatographic system was equipped with
ACE 5 C8 (50 X 2.1 mm) column and utilized a mobile phase composition of 0.5 mM Ammonium
Chloride & 0.04% FA-Methanol (45:55% v/v). The method used three internal standards; AML-D4,
HCTZ-D2 C13 and VAL-D3 with 10% intra- and inter-day precision, and 6% bias for all the analytes.

Results:

The assay was found to be linear with R-2 > 0.998, and the limits of quantification for AML,
VAL and HCTZ were 0.2, 50.0 and 2.0 ng/mL, respectively. The analytes were found to be stable in
plasma samples over short and long term storage.

:

The developed method is rapid with a run time of 3.5 min and cost-effective since the simple sample
preparation method is adopted. This method was successfully applied for the bioequivalence study of
AML, VAL, and HCTZ in human plasma after administration of the fixed-dose combination tablet of
(10/160/25 mg). Pharmacokinetic parameters (Cmax and AUC0-72) for AML and (Cmax, AUC0-t, AUC0-∞)
for VAL and HCTZ were used for bioequivalence assessment. These were determined by noncompartmental
analysis of concentration data.

Conclusion:

The result showed 90% confidence intervals (obtained by ANOVA) which were within
the predefined ranges. As a consequence, this method can be successfully applied for measuring and
quantifying a large number of samples.
Development of Fast and Simple LC-ESI-MS/MS Technique for the Quantification of Regorafenib; Application to Pharmacokinetics in Healthy Rabbits
Authors: Ravi Yatha , Bhikshapathi Darna , Cheruku Shankar , Rajkamal Bigala
Published: November 2019

Background:

A simple quantification technique by liquid chromatography electrospray ionization-
tandem mass spectrometry (LC-ESI-MS/MS) is required for regorafenib in biological matrices
with bioavailability studies in healthy rabbits, when compared with reported techniques.

Objective:

The main aim of the research work was to develop a validated LC-ESI-MS/MS technique
for the quantification of regorafenib and application to bioavailability studies in healthy rabbits.

Methods:

Chromatographic separation was achieved with hypersil-C18 analytical column (50mm×4.6 mm,
4μm) and mobile phase composition of acetonitrile and 5mM ammonium acetate in the proportion of
70:30. The mobile phase was infused into the column with high pressure to get a 0.7 ml/min flow rate.
The total retention time of the analyte is promising when compared with the existed methods for
regorafenib. Quantitation was processed by monitoring transitions of m/z -483.0/262.0 and 450.0/260.0
for regorafenib and internal standard respectively in multiple reaction monitoring.

Results:

The linearity equation and correlation coefficient (R2) findings were y =0.9948x+2.6624 and
0.998 respectively. The intra and inter-day precision of the developed technique was found between
1.00 – 8.50% for the QC-samples (2, 4, 240 and 480ng/ml). From bioavailability study, the drug was
shown Tmax of 3.688 ± 0.754; average AUC0→α and AUC0→t were 6476.81 ± 259.59 and 6213.845 ±
257.892 respectively and Cmax was found to be 676.91 ± 22.045 in healthy rabbits.

Conclusion:

The developed technique was validated and successfully applied in the pharmacokinetic
study of the drug (40 mg tablet) administered through the oral route in healthy rabbits.
Health Beneficial Potential of Pectolinarigenin on Human Diseases: An Updated Review of Medicinal Importance and Pharmacological Activity
Authors: Patel Kanika , Patel Dinesh Kumar
Published: November 2019

Medicinal Plants are valuable source of phytochemicals which have been used in the medicine
as source of raw material since very ancient time in the world. Flavonoids are one of the important
classes of phytochemical basically present in the fruits, vegetables, grains, wine, tea etc. Flavonoids
also play an important role in the defense mechanism of plants and produce different colours
in the plants. Pectolinarigenin is a natural flavonoidal compound having molecular formula
C17H14O6 and molecular weight 314.28. Pectolinarigenin is present in various plants and examples
are Clerodendrum phlomidis, Eupatorium odoratum, Cirsium chanroenicum, Cirsium japonlcum,
Chromolaena odorata, Cirsium setidens, and Trollius chinensis. Pectolinarigenin acts as an anticancer
agent against various types of human malignancies, such as lung cancer, melanoma, hepatocellular
carcinoma and colorectal adenocarcinoma. It has also anti-inflammatory, anti-allergy, cytotoxic
and hepatoprotective properties. Pectolinarigenin gained attention from researchers and clinicians
due to their anticancer properties and in future it could be the best choice for cancer treatment. The purpose
of this review paper is to summarize all the pharmacological properties of pectolinarigenin on
cancer and other disorders, describe the mode of action and possible pathways for cellular level action.
The present review initially highlights the current status of flavonoids and their pharmaceutical importance,
role of pectolinarigenin in human disorders, and in later section, summarizes analytical techniques
of pectolinarigenin as lead molecules. This review will support all the ongoing research of pectolinarigenin
through out world for their beneficial properties in all the scientific discipline.
Design and Optimization of Itraconazole Loaded SLN for Intranasal Administration Using Central Composite Design
Authors: Rana Sarvjeet S. , Bhatt Shailendra , Kumar Manish , Malik Anuj , Sharma Jai B. , Arora Deepshi , Saini Vipin
Published: November 2019

Introduction:

Solid Lipid nanoparticles (SLN) are comprising of a solid lipid core with
a mean diameter between 50 and 1000 nm. SLN is an advanced carrier system to traditional colloidal
carriers such as emulsion, liposomes, and polymeric microparticles.

Objective:

The objective of this study was to formulate SLN of Itraconazole (ITZ) for intranasal
administration.

Methods:

ITZ-loaded SLN were prepared by high pressure homogenization technique using the
Central Composite Design (CCD). The concentration of surfactant (X1) and drug to lipid ratio
(X2) was considered as independent variables, whereas particle size (Y1) and percentage entrapment
efficiency (Y2) were considered as a response. The compatibility of ingredients with the drug
was tested using differential scanning calorimetry. SLN were characterized for their particle size,
entrapment efficiency, transmission electron microscopy, in vitro drug release, and ex vivo study.

Results:

The solid lipid nanoparticles were successfully prepared using high pressure homogenization
technique and glyceryl monostearate was used as solid lipid. The lipid ratio significantly increases
the particle size as well as entrapment efficiency. The particle size and (%) entrapment efficiency
of optimized formulation were found to be 29 nm and 78.9%, respectively. The differential
scanning calorimetry confirmed that the drug existed in amorphous form. Nasal histopathology
study on sheep mucosa revealed that the developed SLN was non-toxic and safe to use for intranasal
administration. The results of ex vivo study showed that the Higuchi pattern of drug release
was followed. The in vitro release studies showed the significant difference in drug release from
ITZ-loaded SLN compared to plain ITZ-solution.

Conclusion:

ITZ-loaded SLN were successfully prepared and validated. The best batch was selected
based on the desired particle size, and EE which is an important characteristic for SLN formulations.
The developed formulations were nontoxic as determined by histo-pathological studies.
A Strategic Imperative for Promoting Hospital Branding: Analysis of Outcome Indicators
Authors: Shieh Gow-Jen , Wu Shi-Liang , Tsai Che-Fu , Chang Chi-Sen , Chang Tsung-Hung , Lui Ping-Wing , Yao Yuh , Sheu Wayne Huey-Herng
Published: November 2019

Background

Optimizing the use of social media to promote hospital branding is important in the present digital era. In Taiwan, only 51.1% of hospitals have official Facebook fan pages. The numbers of likes for these hospitals are also relatively low.

Objective

Our objective was to establish a special branding team for social media operation, led by top administrators of our hospital. Here we present our strategic imperative for promoting hospital branding as well as an analysis of its effectiveness.

Methods

Led by top administrators, the branding team was formed by 11 divisions to create branding strategies. From 2016 to 2018, the team implemented action plans. All information unique to the hospital was posted on Facebook, as well as on the hospital’s official website. To determine the plans’ efficiencies, we obtained reference data from Google Analytics, and we compared Facebook Insights reports for 2016 with those for 2017 and 2018.

Results

One of the branding team’s main missions was to establish branding strategies and to integrate segmental branding messages. In each quarter we regularly monitored a total of 52 action plan indicators, including those for process and outcome, and discussed the results at team meetings. We selected 4 main performance outcome indicators to reflect the effectiveness of the branding efforts. Compared with 2016, the numbers of likes posted on the Facebook fan page increased by 61.2% in 2017 and 116.2% in 2018. Similarly, visits to the hospital website increased by 4.8% in 2017 and 33.1% in 2018. Most Facebook fan page and website viewers were in 2 age groups: 25 to 34 years, and 35 to 44 years. Women constituted 60.42% (14,160/23,436) of Facebook fans and 59.39% (778,992/1,311,605) of website viewers. According to the Facebook Insights reports, the number of likes and post sharing both increased in 2017 and 2018, relative to 2016. Comment messages also increased from 2016 to 2018 (P=.02 for the trend). The most common theme of posts varied over time, from media reports in 2016, to innovative services in both 2017 and 2018. Likes for innovative services posts increased from 2016 through 2018 (P=.045 for the trend). By the end of 2018, we recorded 23,436 cumulative likes for posts, the highest number among medical centers in Taiwan.

Conclusions

We achieved the largest number of Facebook fans among all medical centers in Taiwan. We would like to share our experience with other hospitals that might be interested in engaging in social media for future communications and interactions with their patients.
A Data-Driven Social Network Intervention for Improving Organ Donation Awareness Among Minorities: Analysis and Optimization of a Cross-Sectional Study
Authors: Murphy Michael Douglas , Pinheiro Diego , Iyengar Rahul , Lim Gene , Menezes Ronaldo , Cadeiras Martin
Published: November 2019

Background

Increasing the number of organ donors may enhance organ transplantation, and past health interventions have shown the potential to generate both large-scale and sustainable changes, particularly among minorities.

Objective

This study aimed to propose a conceptual data-driven framework that tracks digital markers of public organ donation awareness using Twitter and delivers an optimized social network intervention (SNI) to targeted audiences using Facebook.

Methods

We monitored digital markers of organ donation awareness across the United States over a 1-year period using Twitter and examined their association with organ donation registration. We delivered this SNI on Facebook with and without optimized awareness content (ie, educational content with a weblink to an online donor registration website) to low-income Hispanics in Los Angeles over a 1-month period and measured the daily number of impressions (ie, exposure to information) and clicks (ie, engagement) among the target audience.

Results

Digital markers of organ donation awareness on Twitter are associated with donation registration (beta=.0032; P<.001) such that 10 additional organ-related tweets are associated with a 3.20% (33,933/1,060,403) increase in the number of organ donor registrations at the city level. In addition, our SNI on Facebook effectively reached 1 million users, and the use of optimization significantly increased the rate of clicks per impression (beta=.0213; P<.004).

Conclusions

Our framework can provide a real-time characterization of organ donation awareness while effectively delivering tailored interventions to minority communities. It can complement past approaches to create large-scale, sustainable interventions that are capable of raising awareness and effectively mitigate disparities in organ donation.
International ResearchKit App for Women with Menstrual Pain (Development, Access, and Engagement): Pragmatic Randomized Control Trial
Authors: Wang Jiani , Rogge Alizé A , Armour Mike , Smith Caroline A , D’Adamo Christopher R , Pischke Claudia R , Yen Hung-Rong , Wu Mei-Yao , Moré Ari Ojeda Ocampo , Witt Claudia M , Pach Daniel
Published: November 2019

Background

Primary dysmenorrhea is a common condition in women of reproductive age. A previous app-based study undertaken by our group demonstrated that a smartphone app supporting self-acupressure introduced by a health care professional can reduce menstrual pain.

Objective

This study aims to evaluate whether a specific smartphone app is effective in reducing menstrual pain in 18- to 34-year-old women with primary dysmenorrhea in a self-care setting. One group of women has access to the full-featured study app and will be compared with 2 control groups who have access to fewer app features. Here, we report the trial design, app development, user access, and engagement.

Methods

On the basis of the practical implications of the previous app-based study, we revised and reengineered the study app and included the ResearchKit (Apple Inc) framework. Behavior change techniques (BCTs) were implemented in the app and validated by expert ratings. User access was estimated by assessing recruitment progress over time. User evolution and baseline survey respondent rate were assessed to evaluate user engagement.

Results

The development of the study app for a 3-armed randomized controlled trial required a multidisciplinary team. The app is accessible for the target population free of charge via the Apple App Store. In Germany, within 9 months, the app was downloaded 1458 times and 328 study participants were recruited using it without external advertising. A total of 98.27% (5157/5248) of the app-based baseline questions were answered. The correct classification of BCTs used in the app required psychological expertise.

Conclusions

Conducting an innovative app study requires multidisciplinary effort. Easy access and engagement with such an app can be achieved by recruitment via the App Store. Future research is needed to investigate the determinants of user engagement, optimal BCT application, and potential clinical and self-care scenarios for app use.

Trial Registration

ClinicalTrials.gov NCT03432611; https://clinicaltrials.gov/ct2/show/NCT03432611 (Archived by WebCite at http://www.webcitation.org/75LLAcnCQ).
Precourse Preparation Using a Serious Smartphone Game on Advanced Life Support Knowledge and Skills: Randomized Controlled Trial (Preprint)
Authors: Phungoen Pariwat , Promto Songwoot , Chanthawatthanarak Sivit , Maneepong Sawitree , Apiratwarakul Korakot , Kotruchin Praew , Mitsungnern Thapanawong
Published: November 2019

BACKGROUND

In the past several years, gamified learning has been growing in popularity in various medical educational contexts including cardiopulmonary resuscitation (CPR) training. Furthermore, prior work in Basic Life Support (BLS) training has demonstrated the benefits of serious games as a method for pretraining among medical students. However, there is little evidence to support these benefits with regard to Advanced Life Support (ALS) training.

OBJECTIVE

We compare the effects of a brief precourse ALS preparation using a serious smartphone game on student knowledge, skills, and perceptions in this area with those of conventional ALS training alone.

METHODS

A serious game (Resus Days) was developed by a Thai physician based on global ALS clinical practice guidelines. Fifth-year medical students were enrolled and randomized to either the game group or the control group. Participants in both groups attended a traditional ALS lecture, but the game group was assigned to play Resus Days for 1 hour before attending the lecture and were allowed to play as much as they wished during the training course. All students underwent conventional ALS training, and their abilities were evaluated using multiple-choice questions and with hands-on practice on a mannequin. Subject attitudes and perceptions about the game were evaluated using a questionnaire.

RESULTS

A total of 105 students participated in the study and were randomly assigned to either the game group (n=52) or the control group (n=53). Students in the game group performed better on the ALS algorithm knowledge posttest than those in the control group (17.22 [SD 1.93] vs 16.60 [SD 1.97], P=.01; adjusted mean difference [AMD] 0.93; 95% CI 0.21-1.66). The game group’s pass rate on the skill test was also higher but not to a statistically significant extent (79% vs 66%, P=.09; adjusted odds ratio [AOR] 2.22; 95% CI 0.89-5.51). Students indicated high satisfaction with the game (9.02 [SD 1.11] out of 10).

CONCLUSIONS

Engaging in game-based preparation prior to an ALS training course resulted in better algorithm knowledge scores for medical students than attending the course alone.

CLINICALTRIAL

Thai Clinical Trials Registry HE611533; https://tinyurl.com/wmbp3q7
The Use of Text Messaging to Improve Clinical Engagement for Individuals With Psychosis: Systematic Review (Preprint)
Authors: D'Arcey Jessica , Collaton Joanna , Kozloff Nicole , Voineskos Aristotle N , Kidd Sean A , Foussias George
Published: November 2019

BACKGROUND

Individuals experiencing psychosis are at a disproportionate risk for premature disengagement from clinical treatment. Barriers to clinical engagement typically result from funding constraints causing limited access to and flexibility in services. Digital strategies, such as SMS text messaging, offer a low-cost alternative to potentially improve engagement. However, little is known about the efficacy of SMS text messaging in psychosis.

OBJECTIVE

This review aimed to address this gap, providing insights into the relationship between SMS text messaging and clinical engagement in the treatment of psychosis.

METHODS

Studies examining SMS text messaging as an engagement strategy in the treatment of psychosis were reviewed. Included studies were published from the year 2000 onward in the English language, with no methodological restrictions, and were identified using 3 core databases and gray literature sources.

RESULTS

Of the 233 studies extracted, 15 were eligible for inclusion. Most studies demonstrated the positive effects of SMS text messaging on dimensions of engagement such as medication adherence, clinic attendance, and therapeutic alliance. Studies examining the feasibility of SMS text messaging interventions found that they are safe, easy to use, and positively received.

CONCLUSIONS

Overall, SMS text messaging is a low-cost, practical method of improving engagement in the treatment of psychosis, although efficacy may vary by symptomology and personal characteristics. Cost-effectiveness and safety considerations were not adequately examined in the studies included. Future studies should consider personalizing SMS text messaging interventions and include cost and safety analyses to appraise readiness for implementation.

CLINICALTRIAL
25 лет официальному представительству LECO Corporation в России и странах СНГ
Authors: Чиркин Д.Б.
Published: November 2019

Рассказывает директор по продажам ЗАО «ЛЕКО ЦЕНТР-М»
Дмитрий Борисович Чиркин
Корпорация LECO известна во всем мире как производитель широкого спектра высокотехнологичного аналитического оборудования для различных отраслей производства и исследовательской деятельности. Продукция компании всегда отвечала растущим потребностям современного общества. Первые приборы – ​анализаторы различных элементов – ​предназначались для работы на предприятиях тяжелой промышленности, сегодня LECO предлагает ряд инновационных решений, идеально подходящих для исследований в области фармацевтики, метаболомики, криминалистики, токсикологии, анализа ароматов и др. методами хроматографии и масс-спектрометрии. Четверть века на российском рынке активно и плодотворно работает представительство корпорации LECO. Об истории компании, особенностях оборудования, а также успехах и перспективах работы мы расспросили директора по продажам ЗАО «ЛЕКО ЦЕНТР-М» Дмитрия Борисовича Чиркина.
JULABO – четверть века на российском рынке
Authors: Зубко И.
Published: November 2019

Рассказывает менеджер по продажам компании JULABO Игорь Зубко
Более пяти десятилетий компания JULABO является одним из мировых лидеров в производстве термостатирующего оборудования. Продукция компании устанавливает новые стандарты на мировом рынке систем температурного контроля. Залог успешной работы компании – ​квалифицированные сотрудники, профессиональная система управления производством, качество продукции и высокий уровень сервисного обслуживания. Одно из инновационных направлений, активно развиваемых компанией, – ​термостатирование на основе жидких теплоносителей. В 1994 году компания JULABO прошла сертификацию по DIN EN ISO 9001, продукция соответствует европейским и интернациональным стандартам.
О новинках, представленных на выставке analytica в Мюнхене, корреспондент журнала побеседовал с менеджером по продажам Игорем Зубко.
Verder Scientific на рынке лабораторного оборудования
Authors: Рееве С.
Published: November 2019

Рассказывает инженер по продажам компании Verder Scientific Скотт Рееве
Компания Verder Scientific, являющаяся подразделением холдинга Verder Group, специализируется в области высокотехнологичного научного оборудования для контроля качества, исследований и разработок твердых материалов. Численность персонала компаний, объединенных брендом Verder Scientific, составляет около 800 человек, которые занимаются разработкой и производством лабораторного оборудования для пробоподготовки для материаловедения и металлографии, подготовки проб измельчением и гомогенизацией, термической обработки (физические испытания материалов), определения размеров и формы частиц сыпучих материалов, измерения твердости, а также элементного состава. Оборудование выпускается фирмами ATM, Carbolite, Carbolite Gero, ELTRA, Retsch, Retsch Technology и QNESS.
На выставке analytica 2018 Verder Scientific показала целый ряд новинок, представляющих большой интерес, в том числе и для российских потребителей. О некоторых самых востребованных экспонатах рассказал инженер по продажам компании Скотт Рееве.
27-я Российская конференция по электронной микроскопии. 5-я Молодежная школа РКЭМ – 2018
Authors: Авилов А.С. , Васильев А.Л.
Published: November 2019

Продолжен рассказ о 27-й Российской конференции по электронной микроскопии (РКЭМ) «Современные методы электронной и зондовой микроскопии в исследованиях органических, неорганических наноструктур и нанобиоматериалов», которая проходила с 26 по 30 августа 2018 года в Черноголовке (Московская область). В рамках конференции прошла 5-я молодежная школа, в которой приняли участие приглашенные докладчики и их молодые коллеги. На школе прозвучали доклады, посвященные различным методам электронной микроскопии и микроанализа, а также их применению в различных областях: медицине, биологии, материаловедении, в исследованиях предметов культурного наследия и т. д.
Масс-спектрометрия для исследования коррозионных процессов на поверхностях конструкционных материалов
Authors: Буряк А.К. , Платонова Н.П. , Пыцкий И.С. , Ульянов А.В.
Published: November 2019

Для исследования продуктов коррозии на поверхности конструкционных материалов предложен комплекс методов, состоящий из термодесорбционной масс-спектрометрии, хромато-масс-спектрометрии, газовой хроматографии – масс-спектрометрии, высокоэффективной жидкостной хроматографии – масс-спектрометрии и активированной матрицей/поверхностью лазерной десорбцией/ионизацией. С помощью выбранных методов можно одновременно анализировать все классы органических и неорганических соединений в широком диапазоне их молекулярных масс на поверхностях разного типа. На примере сплавов АМг-6 и Aд-0, контактировавших с коррозионно-активными компонентами ракетного топлива, отработана методика и показаны преимущества и эффективность совместного использования комплекса методов.
Определение следов стабилизаторов химической стойкости бездымных порохов методом тандемной газовой хромато-масс-спектрометрии
Authors: Ладонин А.В. , Тузков Ю.Б.
Published: November 2019

Предложен способ высокочувствительного одновременного определения стабилизаторов химической стойкости бездымных порохов – дифениламина, централита I (N,N’-диэтил-N,N’-дифенилмочевины) и централита II (N,N’-диметил-N,N’-дифенилмочевины) методом газовой хроматографии – тандемной масс-спектрометрии. Оптимизированы параметры детектирования аналитов в режиме мониторинга выбранных реакций, подобраны условия их эффективного разделения на неполярной колонке TG-5MS. Установлены пределы детектирования, разработан метод количественного анализа с использованием внутреннего стандарта.
Использование вторичных мишеней в энергодисперсионных рентгено-­флуоресцентных спектрометрах Genius IF
Authors: Каменщиков А.Е. , Лавренов И.В. , Фомин В.Е.
Published: November 2019

Рентгенофлуоресцентный анализ (РФА) – один из лучших аналитических методов элементного анализа самых различных проб: твердых веществ, жидкостей и порошков. Описан принцип работы аппаратуры для энергодисперсионного (ЭД) РФА. Обсуждаются способы увеличения чувствительности путем улучшения эффективности регистрации сигнала рентгеновской люминесценции с помощью применения фильтров и вторичных мишеней. Проведены эксперименты при прямом возбуждении образца, а также с применением фильтров и вторичных мишеней. Продемонстрированы примеры практического применения, в которых наблюдается значительное увеличение соотношения сигнал / шум при использовании вторичных мишеней во всем спектральном диапазоне при соответствующем выборе материала мишени. Экспериментально показано влияние материала мишени на интенсивность линий аналитов.
Economía del Ave María: El modelo teórico detrás de las políticas monetarias no convencionales
Authors: Rochon Louis-Philippe , Vallet Guillaume
Published: November 2019

 

Si bien la era de las tasas de interés negativas no parece haber terminado, al menos por el momento, sigue siendo un tema sobre el que vale la pena reflexionar, especialmente en un intento por comprender sus raíces teóricas, y particularmente a la luz de una posible desaceleración en la actividad económica en Estados Unidos y en otras geografías (al momento de escribir este artículo). Este documento examina la evolución de la política monetaria desde la crisis y se centra en las llamadas políticas no convencionales como la flexibilización cuantitativa (QE) y las tasas de interés negativas, argumentando que desde una perspectiva teórica, aunque neoclásica, ambas políticas están relacionadas y basadas en el mismo modelo de multiplicador de dinero.

 
Analisis Derajat Kepatuhan Wajib Pajak (UKM) terhadap Tax Amnesty
Authors: Setu Setyawan Setu
Published: November 2019

Penelitian ini bertujuan untuk menganalisis derajat kepatuhan wajib pajak terhadap tax Amnesty.  Kepatuhan wajib pajak diproxikan dengan kesadaran, pengetahuan peraturan perpajakan, persepsi atas efektivitas sistem perpajakan, dan kepercayaan kepada pemerintahan. Tujuan penelitian ini untuk membuktikan secara empiris sejauh mana derajat kepatuhan  wajib pajak atas kebjiakan tax amnnesty yang diprogramkan oleh pemerintah. Obyek penelitian adalah wajib pajak orang pribadi pelaku UKM di Malang Raya. Data diperoleh dengan membagikan kuesioner kepada 96 pemilik UKM sebanyak 96 respoden. dengan teknik convenience sampling. Analisis data menggunakan regresi linier berganda, dan untuk menentukan hipotesis digunakan uji F, dan uji t. Hasil analisis menunjukkan bahwa variabel kesadaran dengan nilai beta sebesar 0.289, pengetahuan peraturan perpajakan  dengan nilai beta sebesar 0.320, dan Derajat kepercayaan kepercayaan kepada pemerintah nilai beta sebesar 0.392, ketiga variabel tersebut berpengaruh positif dan signifikan terhadap tax amnesty  pajak wajib pajak Pelaku UKM. Sedangkan pengetahuan peraturan perpajakan dengan nilai beta sebesar 0.176 berpengaruh negatif dan tidak signifikan terhadap tax amnesty. Kata kunci: kepatuhan; wajib pajak; tax amnety
Pemberdayaan dan Budaya Organisasi Pada Home Industri Produk Kreatif di Bangil
Authors: Ambarwati Titiek
Published: November 2019

Research objectives: (1) to analyze the empowerment of creative home industry products in Bangil. (2) to analyze the organizational culture in the home industry of creative products in Bangil. This research was conducted at home creative product industry in Bangil, the type of research used in this research is descriptive qualitative because the research is used to study a phenomenon in the object of research. While the object in the study of employees in the home industry creative products in Bangil. The method of data collection used in this research is the use of interview techniques and questionnaires (Questionnaire). Determination of the sample in this study was conducted by using the census method or total sampling with the number of respondents as many as 28 employees, especially the embroidery. Data analysis tool using Range Scale analysis to analyze employee empowerment and analyze organizational culture. The results of the research are as follows: for employee empowerment tendency on the dimension of access (opportunity) is high, the dimensions of participation tendency enough, the dimensions of decision making tendency and dimension of courage to take the risk of low tendency so that the average for employee empowerment done tendency is enough low. As for the organizational culture tendency in the dimensions of innovation is enough, the dimensions of openness tendency strong and the dimensions of cooperation tendency is enough so that it can be concluded the average organizational culture that applied cederung strong enough.
ANALISIS FAKTOR-FAKTOR YANG MEMEPENGARUHI MINAT MAHASISWA BERWIRAUSAHA
Authors: Saputri Novitasari Agus
Published: November 2019

The purpose of this study is to determine the factors that influence student interest in entrepreneurship. This study uses qualitative research, the sample used is accounting students who have entrepreneurship both in the fields of services, trade and manufacturing. The results of this study indicate that there are four factors that influence student interest in entrepreneurship. These factors are profit generated, freedom in work, personal dreams and independence.
Indeks Saham Syariah Indonesia: Pergerakan Harga dari Perspektif Asimetri Informasi
Authors: Utami Yuni
Published: November 2019

Penelitian ini bertujuan untuk mengetahui dan menganalisis konten asimetri informasi saham pada Indeks Harga Saham Syariah Indonesia (ISSI). Sampel dalam penelitian ini mencakup semua emiten yang masuk indeks ISSI ketika indeks pertama kali diterbitkan yaitu 214 perusahaan emiten. Metode penelitian yang digunakan adalah studi peristiwa dengan alat analisis menggunakan t-Test dan ordinary least squares. Periode jendela yang digunakan mencakup periode 15 hari sebelum dan sesudah pengumuman indeks ISSI. Hasil penelitian menunjukkan bahwa tidak ada perubahan harga saham di sekitar tanggal masuknya saham di indeks ISSI. Hal ini dimungkinkan karena saham yang membentuk indeks ISSI adalah saham yang termasuk dalam Daftar Efek Syariah. Hasil analisis menunjukkan bahwa masuknya saham dalam indeks ISSI tidak mempengaruhi abnormal return. Hal ini disebabkan oleh penerbitan laporan rutin sehingga meminimalisir asimetri informasi.
Struktur Kemiskinan Indonesia: Berapa Besar Pengaruh Kesehatan, Pendidikan dan Kelayakan Hunian?
Authors: Zahra Afifatuz , Fatin A Aulia , Afuwu Hanifah , Auliyah R Rintan
Published: November 2019

Kemiskinan merupakan salah satu indikator untuk melihat keberhasilan pembangunan di suatu negara. Sejak tahun 2015, jumlah penduduk miskin di Indonesia semakin menurun. Penurunan secara signifikan terjadi pada tahun 2017. Ini merupakan pertanda yang baik, sehingga pemerintah perlu mengetahui faktor-faktor apa saja yang dapat menurunkan tingkat kemiskinan di Indonesia. Penelitian ini bertujuan untuk memodelkan struktur kemiskinan di Indonesia dengan SEM-PLS dan mengidentifikasi faktor-faktor yang berpengaruh secara signifikan terhadap kemiskinan di Indonesia pada tahun 2017. Data yang digunakan dalam penelitian ini diperoleh dari publikasi Badan Pusat Statistik. Berdasarkan hasil pemodelan, terdapat pengaruh signifikan dari variabel ekonomi, kondisi hunian, kesehatan, dan pendidikan terhadap kemiskinan di Indonesia.