bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonlinear finite element analysis of short and long reinforced concrete columns confined with GFRP tubes
Authors: Hussein Abdallah Maha , Shazly Mostafa , Mohamed Hamdy M , Masmoudi Radhouane , Mousa Ahmed
Published: March 2017

This paper presents three-dimensional nonlinear finite element models to understand the uniaxial behavior of concrete-filled fiber reinforced polymer tubes. A stress–strain confined model was introduced for the concrete, a damage criteria based on Hashin's failure model was used to model damage and failure of GFRP tubes, and steel bars were modeled based on classic metal plasticity model. A comparison between experimental results found in the literature and the finite element model was conducted regarding the load-deflection curves and the failure pattern of different test specimens. The model was found to be efficient in capturing the loads and deformations of slender concrete-filled fiber reinforced polymer tube columns. It was then used in a parametric study to understand the effect of different parameters (including fiber orientation, number of layers of (glass-fiber reinforced polymer) and steel reinforcement ratio) on the behavior of concrete-filled fiber reinforced polymer tube under axial compressive loading. It was observed that the behavior of the columns was greatly affected by the investigated analysis parameters.
The Role of Interpersonal Relations in Healthcare Team Communication and Patient Safety
Authors: Lee Charlotte Tsz-Sum , Doran Diane Marie
Published: March 2017

Patient safety is compromised by medical errors and adverse events related to miscommunications among healthcare providers. Communication among healthcare providers is affected by human factors, such as interpersonal relations. Yet, discussions of interpersonal relations and communication are lacking in healthcare team literature. This paper proposes a theoretical framework that explains how interpersonal relations among healthcare team members affect communication and team performance, such as patient safety. We synthesized studies from health and social science disciplines to construct a theoretical framework that explicates the links among these constructs. From our synthesis, we identified two relevant theories: framework on interpersonal processes based on social relation model and the theory of relational coordination. The former involves three steps: perception, evaluation, and feedback; and the latter captures relational communicative behavior. We propose that manifestations of provider relations are embedded in the third step of the framework on interpersonal processes: feedback. Thus, varying team-member relationships lead to varying collaborative behavior, which affects patient-safety outcomes via a change in team communication. The proposed framework offers new perspectives for understanding how workplace relations affect healthcare team performance. The framework can be used by nurses, administrators, and educators to improve patient safety, team communication, or to resolve conflicts.
Take Care and Care Well
Authors: Coughlin McNeil Mary
Published: March 2017

Evidence-based practice supports the patient care process by integrating patient values and preferences with clinician expertise and the best available evidence. This approach to patient care focuses on quality and safety with the aim of improving patient outcomes. Despite its obvious value, healthcare professionals struggle to integrate evidence-based best practices into their clinical practice
Increasing Ketamine Use for Refractory Status Epilepticus in US Pediatric Hospitals
Authors: Keros Sotirios , Buraniqi Ersida , Alex Byron , Antonetty Annalee , Fialho Hugo , Hafeez Baria , Jackson Michele C. , Jawahar Rachel , Kjelleren Stephanie , Stewart Elizabeth , Morgan Lindsey A. , Wainwright Mark S. , Sogawa Yoshimi , Patel Anup D. , Loddenkemper Tobias , Grinspan Zachary M.
Published: March 2017

Ketamine is an emerging therapy for pediatric refractory status epilepticus. The circumstances of its use, however, are understudied. The authors described pediatric refractory status epilepticus treated with ketamine from 2010 to 2014 at 45 centers using the Pediatric Hospital Inpatient System database. For comparison, they described children treated with pentobarbital. The authors estimated that 48 children received ketamine and pentobarbital for refractory status epilepticus, and 630 pentobarbital without ketamine. Those receiving only pentobarbital were median age 3 [interquartile range 0-10], and spent 30 [18-52] days in-hospital, including 17 [9-28] intensive care unit (ICU) days; 17% died. Median cost was $148 000 [81 000-241 000]. The pentobarbital-ketamine group was older (7 [2-11]) with longer hospital stays (51 [30-93]) and more ICU days (29 [20-56]); 29% died. Median cost was $298 000 [176 000-607 000]. For 71%, ketamine was given ≥1 day after pentobarbital. Ketamine cases per half-year increased from 2 to 9 ( P < .05). Ketamine is increasingly used for severe pediatric refractory status epilepticus, typically after pentobarbital. Research on its effectiveness is indicated.
Facing Interpersonal Violence: Identifying the Coping Profile of Poly-Victimized Resilient Adolescents
Authors: Kirchner Teresa , Magallón-Neri Ernesto , Forns Maria , Muñoz Dàmaris , Segura Anna , Soler Laia , Planellas Irina
Published: March 2017

Coping strategies are factors that mediate the relationship between interpersonal victimizations and psychological maladjustment. The objectives are as follows: (a) to establish the coping profile of adolescents according to the number of reported interpersonal victimizations; (b) to identify the most victimized adolescents (poly-victims), detecting those with psychological symptoms (nonresilient poly-victims) and those without psychological symptoms (resilient poly-victims), and then to examine any differences in coping strategies between the two groups; (c) to determine the accumulative effect of victimizations on mental health; and (d) to test the mediating role of both approach and avoidance coping between lifetime interpersonal victimizations and symptoms. Participants were 918 community Spanish adolescents (62.7% girls) aged between 14 and 18 years. Measures used were Youth Self-Report, Juvenile Victimization Questionnaire, and Adolescent Coping Orientation for Problem Experiences. The following results were reported: (a) The most victimized adolescents used to a greater degree avoidance coping strategies than nonvictimized adolescents. (b) Resilient poly-victimized adolescents were more likely to seek family support and tended to use more positive reappraisal than nonresilient poly-victimized adolescents. (c) A clear cumulative effect of victimizations on mental health was observed: 45% of the most victimized adolescents (poly-victims) reached clinical range on Youth Self-Report in front of 2% of nonvictimized adolescents. (d) Avoidance coping and more specifically Escaping and Venting feelings strategies played a mediating role between interpersonal victimizations and psychological symptoms. Approach coping had no mediating role, except for Positive reappraisal in girls. In conclusion, the possibility of identifying the coping profile of victimized adolescents may have clinical implications in terms of both prevention and intervention.
A multiobjective aerodynamic optimization design of a high-speed train head under crosswinds
Authors: Zhang Liang , Zhang Jiye , Li Tian , Zhang Yadong
Published: March 2017

In this work, a multiobjective aerodynamic optimization of a high-speed train head was performed to improve the aerodynamic performance of the high-speed train running on an embankment under crosswinds. Seven optimization design variables were selected to control five regions on the train head. The total aerodynamic drag force, aerodynamic lift force, and aerodynamic side force of the head coach were set as the optimization objectives. The optimal Latin hypercube sampling method was used to obtain the values of the design variables of the sample points. The high-speed train head was deformed using the free-form deformation approach through which the mesh morphing was performed without remodeling and re-meshing. Then, the aerodynamic performances of the high-speed trains at the sample points were calculated using the computational fluid dynamics method. A Kriging surrogate model between the design variables and their optimization objectives was constructed. Then, the multiobjective aerodynamic optimization of the high-speed train head was performed using multiobjective genetic algorithms based on the Kriging model. Based on the results of the sample points, the relationships between the optimization design variables and the optimization objectives were analyzed, and the contributions of the primary factors to the optimization objectives were obtained. After optimization, a series of Pareto-optimal head shapes were obtained. The steady and unsteady aerodynamic performances of the train with an optimal head, which was selected from the Pareto-optimal head shapes, were compared with those of the original train.
A review of evolution of electrospun tissue engineering scaffold: From two dimensions to three dimensions
Authors: Ngadiman Nor Hasrul Akhmal , Noordin MY , Idris Ani , Kurniawan Denni
Published: March 2017

The potential of electrospinning process to fabricate ultrafine fibers as building blocks for tissue engineering scaffolds is well recognized. The scaffold construct produced by electrospinning process depends on the quality of the fibers. In electrospinning, material selection and parameter setting are among many factors that contribute to the quality of the ultrafine fibers, which eventually determine the performance of the tissue engineering scaffolds. The major challenge of conventional electrospun scaffolds is the nature of electrospinning process which can only produce two-dimensional electrospun mats, hence limiting their applications. Researchers have started to focus on overcoming this limitation by combining electrospinning with other techniques to fabricate three-dimensional scaffold constructs. This article reviews various polymeric materials and their composites/blends that have been successfully electrospun for tissue engineering scaffolds, their mechanical properties, and the various parameters settings that influence the fiber morphology. This review also highlights the secondary processes to electrospinning that have been used to develop three-dimensional tissue engineering scaffolds as well as the steps undertaken to overcome electrospinning limitations.
Chimeric antigen receptor–engineered T cells for liver cancers, progress and obstacles
Authors: Li Keyu , Lan Yaliang , Wang Jiabei , Liu Lianxin
Published: March 2017

Chimeric antigen receptor–engineered T cells therapy has become the hottest topic of immunotherapy, as its great successes achieved in treating refractory hematological malignancies. These successes also paved the road to novel strategies of treating various solid tumors including liver cancer. Many specific proteins can be expressed aberrantly in liver cancers; therefore, a series of experimental and clinical researches exploring chimeric antigen receptor–engineered T cells and liver cancer are in progress, acquiring obvious antitumor effect and revealing its feasibility in treating liver cancer. However, lots of challenges and obstacles are emerging simultaneously, such as low infiltration, side effects, safety of chimeric antigen receptor–engineered T cells, and limited data of studies or clinical trials. Researchers have been working out many innovative ways to directly stroke these obstacles, theoretically or practically. This review focuses more on the progress and obstacles from chimeric antigen receptor–engineered T cells therapy to treat liver cancer, summarizing new breakthroughs in shooting those obstacles, meanwhile, hoping to provide enlightenment to this promising immunotherapeutic method.
MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer
Authors: Yang Liang , Huang Sheng , Ma Hongbin , Wu Xiaoxiong , Feng Feiling
Published: March 2017

We intended to investigate the functional role and clinical relevance of microRNA-125b in human gallbladder cancer. Quantitative real-time polymerase chain reaction was used to examine microRNA-125b expression in gallbladder cancer cell lines, and 79 pairs of gallbladder cancer and normal gallbladder clinical tissues. Clinical correlations between tumorous microRNA-125b expression and gallbladder cancer patients’ clinicopathological variances or overall survivals were statistically analyzed. In gallbladder cancer cell lines, TYGBK-8 and G-415 cells, microRNA-125b was upregulated to examine its regulatory effect on gallbladder cancer proliferation and migration in vitro. MicroRNA-125b was significantly downregulated in gallbladder cancer cell lines and human gallbladder cancer tumors. MicroRNA-125b in gallbladder cancer was significantly correlated with patients’ clinical stage, tumor differentiation, lymph metastasis, and tumor invasion. Low tumorous microRNA-125b expression was also found to be associated with poor overall survivals among gallbladder cancer patients. In vitro studies demonstrated that microRNA-125b upregulation significantly suppressed proliferation and migration in TYGBK-8 and G-415 cells. Tumorous microRNA-125b is an independent prognostic biomarker for patients with gallbladder cancer and possibly acts as a tumor suppressor in gallbladder cancer.
The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue
Authors: Li Bo , Li Bai , Sun Hongyan , Zhang Haishan
Published: March 2017

MicroRNAs are known as small, non-coding, and single-stranded RNAs which can regulate cell proliferation, differentiation, and apoptosis and involve in the development of tumors. In this study, colorectal cancer tissue morphological change in different prognosis in patients was observed by hematoxylin and eosin staining. Thereafter, differentially expressed miR-22 and TIAM1 gene were detected using quantitative polymerase chain reaction and western blot in different colorectal cancer tissues. Meanwhile, luciferase reporter gene system was used to verify the relationship between miR-22 and TIAM1. Eventually, the survival curve was plotted according to follow-up records of patients with colorectal cancer and the expression levels of miR-22 and TIAM1 in different tumor tissues. The hematoxylin and eosin results showed the poor pathological features in the 1-year survival group. The expression level of miR-22 was upregulated and TIAM1 was inhibited, correlating with the extension of patients’ survival time. Our results indicated that miR-22 and TIAM1 might play a regulatory role in the occurrence and development of colorectal cancer which were consistent with the survival curve analysis results. Furthermore, the luciferase in miR-22 co-transfected with pmiR-RB-REPORT- TIAM1 group was significantly lower than pmiR-RB-REPORT- TIAM1-mut and Si groups. Collectively, these data suggest that miR-22 may suppress the expression of its target gene TIAM1. The low miR-22 level or the high TIAM1 level will indicate the poor prognosis in colorectal cancer patients.
Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer
Authors: Kobayashi Takahiko , Ishida Junich , Shimizu Yuichi , Kawakami Hiroshi , Suda Goki , Muranaka Tetsuhito , Komatsu Yoshito , Asaka Masahiro , Sakamoto Naoya
Published: March 2017

RNA-binding motif 5 is a putative tumor suppressor gene that modulates cell cycle arrest and apoptosis. We recently demonstrated that RNA-binding motif 5 inhibits cell growth through the p53 pathway. This study evaluated the clinical significance of RNA-binding motif 5 expression in gastric cancer and the effects of altered RNA-binding motif 5 expression on cancer biology in gastric cancer cells. RNA-binding motif 5 protein expression was evaluated by immunohistochemistry using the surgical specimens of 106 patients with gastric cancer. We analyzed the relationships of RNA-binding motif 5 expression with clinicopathological parameters and patient prognosis. We further explored the effects of RNA-binding motif 5 downregulation with short hairpin RNA on cell growth and p53 signaling in MKN45 gastric cancer cells. Immunohistochemistry revealed that RNA-binding motif 5 expression was decreased in 29 of 106 (27.4%) gastric cancer specimens. Decreased RNA-binding motif 5 expression was correlated with histological differentiation, depth of tumor infiltration, nodal metastasis, tumor–node–metastasis stage, and prognosis. RNA-binding motif 5 silencing enhanced gastric cancer cell proliferation and decreased p53 transcriptional activity in reporter gene assays. Conversely, restoration of RNA-binding motif 5 expression suppressed cell growth and recovered p53 transactivation in RNA-binding motif 5–silenced cells. Furthermore, RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer.
Highlights on immune checkpoint inhibitors in non–small cell lung cancer
Authors: Shen Meng , Ren Xiubao
Published: March 2017

The treatment of advanced or refractory non–small cell lung cancer has been historically difficult owing to the lack of studies on effective systemic cure. The progress in lung cancer treatment has plateaued, necessitating new options for additional benefits. Immune checkpoint proteins are co-inhibitory factors that can diminish the antigen-specific immune responses by attenuating the regulatory role of cytotoxic T-lymphocyte-associated protein 4, programmed cell death-1, lymphocyte-activation gene 3, and T-cell immunoglobulin mucin-3. The therapeutic strategies targeting immune checkpoints mainly focus on the monoclonal antibody of these regulatory factors, which may facilitate clinical decision making. An enhanced understanding of the drug-resistance mechanisms and the therapeutic efficacy regulation will provide opportunities to improve the clinical outcomes of non–small cell lung cancer patients. Preclinical and clinical trials on these key immune-regulatory agents, which has heralded a new era in immuno-oncology in non–small cell lung cancer treatment, are currently in development.
Comparative proteomics—network analysis of proteins responsible for ursolic acid–induced cytotoxicity in colorectal cancer cells
Authors: Cai Qiaoyan , Lin Jing , Zhang Ling , Lin Jiumao , Wang Lili , Chen Daxin , Peng Jun
Published: March 2017

Ursolic acid is a key active compound present in many medicinal herbs that have been widely used in traditional Chinese medicine for the clinical treatment of various cancers. However, the precise mechanisms of its antitumor activity have been poorly understood. To identify the cellular targets of ursolic acid, two-dimensional gel electrophoresis combined with mass spectrometry was performed in this study, which identified 15 proteins with significantly altered levels in protein expression. This demonstrated that ursolic acid–induced cytotoxicity in colorectal cancer cells involves dysregulation in protein folding, signal transduction, cell proliferation, cell cycle, and apoptosis. Corresponding protein regulation was also confirmed by Western blotting. Furthermore, the study of functional association between these 15 proteins revealed that 10 were closely related in a protein–protein interaction network, whereby the proteins either had a direct interaction with each other or were associated via only one intermediary protein. In this instance, the ATP5B/CALR/HSP90B1/HSPB1/HSPD1-signaling network was revealed as the predominant target which was associated with the majority of the observed protein–protein interactions. As a result, the identified targets may be useful in explaining the anticancer mechanisms of ursolic acid and as potential targets for colorectal cancer therapy.
Silencing of bach1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells
Authors: Mohammadzadeh Reza , Saeid Harouyan Mojgan , Ale Taha Seyed Mansour
Published: March 2017

Background:

Recently experimental validation of the networks revealed bach1, a basic leucine zipper transcription factor, as the common regulator of several functional invasive genes. The expression of bach1 and its target genes was linked to the higher risk of breast cancer recurrence in patients. The aim of this study was to investigate the effect of specific bach1 small interfering RNAs, on the invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor which play a role in cancer metastasis, in MDA-MB-468 cell lines.

Methods:

Small interfering RNA transfection was performed with transfection regent. The survival effects of small interfering RNA were determined using trypan blue assay cells. The expression level of messenger RNA and matrix metalloproteinase-9 to assess cell invasion and the expression level of miR-203, miR-145, and CXCR4 receptor were measured by quantitative real-time polymerase chain reaction analysis on the MDA-MB-468 cell lines.

Results:

Transfection with small interfering RNA significantly suppressed the expression of bach1 gene in dose-dependent manner after 48 h ( p < 0.0001). A significant reduction in cell invasion and CXCR4 receptor, matrix metalloproteinase-9 expression were observed ( p < 0.0001). It was also a dramatic increase in the expression level of miR-203 and miR-145 ( p < 0.0001).

Conclusions:

Our results suggest that the bach1-specific small interfering RNA effectively decrease CXCR4 receptor, matrix metalloproteinase-9 expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR-145. Thus, these microRNAs may play a role in invasive/metastasis of carcinogenic breast cancer cells. Therefore, bach1 knockdown can be considered as a potent adjuvant in breast cancer therapy.
High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway
Authors: He Xiao-Qin , Zhang Yue-Feng , Yu Jia-Jun , Gan Yuan-Yuan , Han Na-Na , Zhang Mei-Xia , Ge Wei , Deng Jun-Jian , Zheng Yong-Fa , Xu Xi-Ming
Published: March 2017

The aim of this study was to investigate the role of G-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B virus-related hepatocellular carcinoma tissues through a hierarchical clustering analysis. With this study, we first assessed the expression pattern of G-protein signaling modulator 2 in hepatocellular carcinoma specimens and adjacent noncancerous tissues; clinical data were analyzed, along survival times, utilizing the Kaplan–Meier method. Moreover, the functions of G-protein signaling modulator 2 were examined using small-interfering RNAs in vitro. The results showed that G-protein signaling modulator 2 was clearly overexpressed in hepatocellular carcinoma tissues and cell lines and that the G-protein signaling modulator 2 expression level was related to tumor size and hepatitis B virus infection. Furthermore, G-protein signaling modulator 2 knockdown studies suggested that G-protein signaling modulator 2 accelerates cell growth, cell cycle, migration, and invasion and inhibits apoptosis, acting as an oncogene in hepatocellular carcinoma. Western blotting indicated that silencing of G-protein signaling modulator 2 in HepG2 and SMMC-7721 cells increased the expression levels of Bax, caspase-3, and E-cadherin, while notably suppressing the cyclin-dependent kinase 4, cyclin-dependent kinase 6, CyclinD1, Snail1, Vimentin, and matrix metallopeptidase 9 expression levels, compared with that in the control groups. In addition, we found that G-protein signaling modulator 2 can affect the expression of key proteins involved in protein kinase B activation. In conclusion, high expression of G-protein signaling modulator 2 was involved in the pathological processes of hepatocellular carcinoma through activation of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which may provide an attractive potential diagnostic biomarker and therapeutic target for treatment of hepatocellular carcinoma.
Trait Empathy associated with Agreeableness and rhythmic entrainment in a spontaneous movement to music task: Preliminary exploratory investigations
Authors: Bamford Joshua Michael Silberstein , Davidson Jane Whitfield
Published: March 2017

The simulation theory of empathy suggests that we use motor processing to empathise, through modelling the actions of others. Similarly, research into embodied music cognition posits that music, particularly musical rhythm, is perceived as a motor stimulus. In both cases, the human Mirror Neuron System (MNS) is put forward as a potential underlying mechanism. If this is the case, some overlap may exist between the ability to empathise with others, and the ability to perceive rhythm in music. The present study investigated this relationship indirectly, through the study of individual differences in Trait Empathy and rhythmic entrainment. Undergraduate students ( N = 237) completed a questionnaire battery including the EQ-Short, BFAS and questions about musical and dance experience. A relationship was observed between Agreeableness on the BFAS and the EQ-Short ( r = .554). Tests on a controlled sample of these participants ( n = 11) found a relationship between Trait Empathy and performance on a rhythmic entrainment task, involving spontaneous movement to a musical stimulus ( rτ = -.686). A novel measure of rhythmic entrainment was used, assessing each participant on the time taken to re-establish entrainment following an abrupt change in tempo. The findings suggest that Empathy and rhythmic entrainment may utilise similar brain regions. These regions may also be associated with the MNS, although neuroimaging data would be required to confirm this. Qualitative observations of the participants’ responses to the various musical stimuli were also recorded, and may inform future study. Furthermore, the observed relationship between Agreeableness and Trait Empathy may have implications for how these personality constructs are treated in the literature.
Complex PTSD – a better description for borderline personality disorder?
Authors: Kulkarni Jayashri
Published: March 2017

Objective:

To consider the use of the diagnostic category ‘complex posttraumatic stress disorder’ (c-PTSD) as detailed in the forthcoming ICD-11 classification system as a less stigmatising, more clinically useful term, instead of the current DSM-5 defined condition of ‘borderline personality disorder’ (BPD).

Conclusions:

Trauma, in its broadest definition, plays a key role in the development of both c-PTSD and BPD. Given this current lack of differentiation between these conditions, and the high stigma faced by people with BPD, it seems reasonable to consider using the diagnostic term ‘complex posttraumatic stress disorder’ to decrease stigma and provide a trauma-informed approach for BPD patients.
Psychometric Testing of Two Chinese-Version Scales on Attitudes Toward and Caregiving Behaviors for End-of-Life Patients and Families
Authors: Yang Luke , Liu Yung-Fang , Sun Huey-Fang , Chiang Hsien-Hsien , Tsai Yu-Lun , Liaw Jen-Jiuan
Published: March 2017

The study purpose was to examine the validities and reliabilities of the Chinese-versions Frommelt Attitudes Toward Care of the Dying Scale (Attitudes Scale) and Caregiving Behaviors Scale for End-of-Life Patients and Families (Behaviors Scale). The scales were tested in a convenience sample of 318 nurses with ≥6 months work experience at three hospitals. Cronbach’s alphas of the Attitudes and Behaviors Scales were .90 and .96, respectively. Each scale had Kaiser–Meyer–Olkin index >.85 and Bartlett’s test of sphericity >4000 ( p < .001). Attitudes Scale loaded on three factors: respecting and caring for dying patients and families, avoiding care of the dying, and involving patients and families in end-of-life care. The Behaviors Scale loaded on two factors: supporting dying patients and families, and helping families cope with grief. Factor loadings for both scales were ≥.49. Both Attitudes and Behaviors Scales are reliable and valid for evaluating nurses’ attitudes and caregiving behaviors for the dying.
Kenneth Waltz is not a neorealist (and why that matters)
Authors: LaRoche Christopher David , Pratt Simon Frankel
Published: March 2017

Faced with scepticism about the status of grand theory in International Relations, scholars are re-evaluating Kenneth Waltz’s contribution to theoretical debates in the field. Readers of Waltz have variously recast his work as structural functionalist, scientific realist and classical realist in liberal clothing. We contribute to this re-evaluation by systematically assembling misreadings of Waltz that continue to occur across all of International Relations’ schools — that his theory is positivist, rationalist and materialist — and offering a coherent synthesis of his main contributions to International Relations theory. By linking Theory of International Politics to both Man, the State, and War and Waltz’s post-1979 clarifications, we show that Waltz offers International Relations scholars a coherent vision of the worth and method of grand theory construction that is uniquely ‘international’. In particular, we focus on Waltz’s methodology of theory building and use of images, demonstrating these to be underappreciated but crucially important aspects of Waltz’s work. We finish by proposing methodological, practical and pedagogical ‘takeaways’ for International Relations scholars that emerge from our analysis.
District-level explanations for supporter involvement in political parties
Authors: Fisher Justin , Cutts David , Fieldhouse Edward , Rottweiler Bettina
Published: March 2017

Traditional analyses of grass roots involvement in political parties have focussed almost exclusively on formal members. However, recent analyses across a range of democracies have shown that non-members (supporters) are playing important roles within political parties, including election campaigning, candidate and leader selection, online policy deliberations and even policy formation. The growing literature on this topic suggests that the involvement of supporters may be a function of party structure and availability of online recruitment. Using new data collected at the 2015 British general election, this article extends the examination of supporter involvement but challenges these assumptions. It shows that supporter activity is better explained by responses to electoral factors and that the focus on online recruitment seriously underplays the enduring importance of human contact.
An m-Health system for education and motivation in cardiac rehabilitation: the experience of HeartCycle guided exercise
Authors: Salvi Dario , Ottaviano Manuel , Muuraiskangas Salla , Martínez-Romero Alvaro , Vera-Muñoz Cecilia , Triantafyllidis Andreas , Cabrera Umpiérrez Maria Fernanda , Arredondo Waldmeyer Maria Teresa , Skobel Erik , Knackstedt Christian , Liedes Hilkka , Honka Anita , Luprano Jean , Cleland John GF , Stut Wim , Deighan Carolyn
Published: March 2017

Introduction

Home-based programmes for cardiac rehabilitation play a key role in the recovery of patients with coronary artery disease. However, their necessary educational and motivational components have been rarely implemented with the help of modern mobile technologies. We developed a mobile health system designed for motivating patients to adhere to their rehabilitation programme by providing exercise monitoring, guidance, motivational feedback, and educational content.

Methods

Our multi-disciplinary approach is based on mapping “desired behaviours” into specific system’s specifications, borrowing concepts from Fogg’s Persuasive Systems Design principles. A randomised controlled trial was conducted to compare mobile-based rehabilitation (55 patients) versus standard care (63 patients).

Results

Some technical issues related to connectivity, usability and exercise sessions interrupted by safety algorithms affected the trial. For those who completed the rehabilitation (19 of 55), results show high levels of both user acceptance and perceived usefulness. Adherence in terms of started exercise sessions was high, but not in terms of total time of performed exercise or drop-outs. Educational level about heart-related health improved more in the intervention group than the control. Exercise habits at 6 months follow-up also improved, although without statistical significance.

Discussion

Results indicate that the adopted design methodology is promising for creating applications that help improve education and foster better exercise habits, but further studies would be needed to confirm these indications.
Women's voices made visible: Photovoice in visual criminology
Authors: Fitzgibbon Wendy , Stengel Camille M
Published: March 2017

The voices of women subject to the criminal justice system are often ignored and unheard. This article considers the effectiveness of photovoice, a form of participatory photography research, as a visual method of enabling and communicating marginalised women’s experiences in criminological research. By utilising the potentially empowering technique of photovoice in two research projects, the narratives of women who inject drugs in Hungary and women who have experienced supervision in England are conveyed through their own participant-generated photographs. These images convey the pains and aspirations of the participants' lives and show how photovoice is a useful method for visual criminological research and exposes the shared problems faced by two vulnerable populations across two countries in Europe.
Underground penality: The IRA’s punishment of informers
Authors: Dudai Ron
Published: March 2017

This article seeks to open a novel venue for punishment and society scholarship: the penal logics of armed groups – non-state actors engaged in direct struggle with the state agencies that normally carry out criminal justice. Though many armed groups establish penal systems, applying to their members or the communities under their influence, this issue has thus far not received adequate attention in criminological literature. In exploring this phenomenon this article introduces the concept of ‘underground penality’: organized punishment which is unlawful under state law, occurs in the context of an armed campaign against the state, and is aimed at controlling behaviour deemed deviant by those groups. The potential of research on this topic is demonstrated by interpreting the punishment of informers by the Irish Republican Army (IRA) during the Northern Ireland conflict. Three key themes emerging from the research are identified and analysed: underground penality as ‘state prefiguration’ – interpreting rebel penal practices as part of an effort to convey a state-like image; underground penality as social control – analysing direct violence against suspected informers within a broader social control system; and underground penality as ‘legitimation work’ – the effects of legitimacy considerations in constraining and shaping punishment by armed groups.
Safe and Inclusive Research Practices for Qualitative Research Involving People with Dementia: A Review of Key Issues and Strategies
Authors: Novek Sheila , Wilkinson Heather
Published: March 2017

Aim

Developing strategies to ensure the safe participation of people with dementia in research is critical to support their wider inclusion in research and to advance knowledge in the areas of dementia policy and practice.

Objectives

This literature review synthesizes and critically appraises different approaches to promote the safe participation of people with dementia in qualitative research.

Methods

Two databases were searched for articles that discuss the methodological or ethical aspects of qualitative research involving people with dementia. We did not focus on informed consent or ethical review processes as these have been reviewed elsewhere.

Findings

Key issues that impact participant safety include: language, gatekeepers, the research relationship, communication, dealing with distress, knowledge dissemination, and researcher skills.

Conclusion

By synthesizing different approaches to safety and highlighting areas of debate, we hope to advance discussion and to contribute to the development of inclusive research methods.
Commitment in College Student Persistence
Authors: Savage Matthew W. , Strom Renee E. , Ebesu Hubbard Amy S. , Aune Krystyna S.
Published: March 2017

This investigation theoretically extended Tinto’s model of student persistence by drawing on interpersonal communication research to elaborate on the role of commitment in student persistence. College student departure literature was reviewed and critiqued concerning the conceptualization and measurement of commitment within the interactionalist model of student persistence. Rusbult’s investment model was used as an exploratory theoretical frame for understanding commitment between students and institutions. Self-report measures of commitment and investment model predictors for students in higher education were included. Support was found for hypotheses using the investment model as a frame for understanding how both students’ commitment and perceptions of their institution’s commitment are relevant in understanding persistence in the higher education setting.
Kenyan girls as agents of peace: Enhancing the capacity of future women peacebuilders
Authors: Zanoni Katie
Published: March 2017

The role of women in peacebuilding efforts has been recognized through various international instruments that have advanced the ability of women to access the peace table. In order for women to act as leaders, they must possess the capacity to disrupt structural, cultural, and direct forms of violence, engage in peacemaking activities, and employ prevention strategies for sustainable peace to be secured. This paper draws on qualitative research on a leadership program called Women of Integrity, Strength, and Hope (WISH) offered at the Daraja Academy, an all-girls boarding school in Kenya. The case study is situated within the larger global context of the women’s peace movement galvanized by the United Nations to highlight the potential role women may offer as peacebuilders. The WISH program engages Kenyan girls through critical peace education pedagogy to enhance capabilities required for future female architects of sustainable peace in Kenya and in the world.
Reclaiming reconciliation through community education for the Muslims and Tamils of post-war Jaffna, Sri Lanka
Authors: Duncan Ross , Cardozo Mieke Lopes
Published: March 2017

This paper explores the possibilities and challenges for ethno-religious reconciliation through secondary school education in post-war Sri Lanka, with a specific focus on the Muslim and Tamil communities in the Northern city of Jaffna. In doing so, we position our paper within the growing field of ‘education, conflict and emergencies’ of which there has been a growing body of literature discussing this contentious relationship. The paper draws from an interdisciplinary and critical theoretical framework that aims to analyse the role of education for peacebuilding, through a multi-scalar application of four interconnected dimensions of social justice: redistribution, recognition, representation and reconciliation (or 4 R’s, Novelli, Lopes Cardozo and Smith, 2015). We apply this framework to interpret primary data collected through an ethnographic study of two under-studied communities that have been disproportionately affected by the 1983 to 2009 civil war and displacement: the Northern Sri Lankan Muslims and Northern Sri Lankan Tamils. We find that structural inequalities in society are replicated in formal secondary school education and are perceived to be perpetuating ethno-religious conflict between Muslim and Tamil; second, through a multi-scalar analysis, formal peace education is perceived by respondents not to be meeting the needs of communities; and third, we observe how in response to failings of state peace education, an ‘unofficial’ Tamil–Muslim community education incorporating a social justice-based approach has emerged. This has facilitated a process of cross-community reconciliation between Muslim and Tamil through individual (teachers, students) and community (Muslim–Tamil community based organisations) agency. The paper concludes by offering suggestions for peace education policy and future research.
Children’s conceptions of peace in two Ugandan primary schools: Insights for peace curriculum
Authors: Kagaari James , Nakasiita Kirabo , Ntare Edward , Atuhaire Richard , Baguwemu Ali , Ojok Gerald , Okumu Auma S , Kaahwa Goretti , Byamugisha Gastone , Semakula Paul , Namusoke Jane , Mayengo Nathan , Dennis Barbara , Thompson Chalmer E
Published: March 2017

Oppenheimer urged communities all over the world to study how children come to understand peace, conflict, and war. Set in various countries, their review of studies, as well as more recent examinations reveal trends in how children view these phenomena, often differing by gender, age, and extent to which they were exposed to highly dangerous and traumatizing situations, like being forced to be child soldiers or sex slaves. No such research has been published in the contemporary post-war Uganda context. Using focus group methodology, we asked: How might Ugandan primary school children’s stories about peace (traditional and otherwise) help them navigate conflict? What sorts of conflicts do these children observe in their home, school, and community, and how do they describe peace as being resolved by themselves or others? The purpose of our study was to contribute to the knowledge base on peace education in Uganda and to ultimately develop written materials that students can use as part of their learning in their respective schools. Local studies like this one are relevant to the global situation because racial and economic conditions are global phenomena. The local manifestations can speak to those racial and economic conditions as perspectives not often used to put the global situation in relief. This paper explores the findings related to the children’s overarching conceptions of peace and their ideas of peacebuilding, including activities that both hinder and encourage peace. The voices of the children speak strongly of the connection between peace and access to basic necessities in the community.
Ideology, utopia and Islam on campus: How to free speech a little from its own terrors
Authors: Scott-Baumann Alison
Published: March 2017

A dominant narrative on many British campuses is ‘Prevent’, which is part of the government’s counter-terror policy, an ideology based on fear. Muslims, in particular, are considered to be at risk of radicalisation on campus, and being under suspicion makes them self-censor. Additionally, the no-platforming student lobby creates a utopian, idealised atmosphere that seeks to reduce dissent. Self-censorship and no-platforming are reducing the diversity of opinions expressed at universities, yet there is no evidence of illegality on campus. Spinoza, JS Mill and Hannah Arendt demanded various forms of free speech for a healthy society, and the free speech issue is the key to ‘Prevent’ which suppresses opinions that are different from the dominant government narratives. The challenge now, in the tide of BREXIT and Trump, is how to free speech, even a little, from the pincer grip of establishment ideology and student utopia. Between the extremes of ideology and utopia is a vacuum that must be filled; if we do not fill it with free speech and discussion, others can colonise it with stories that inspire fear and suspicion. Similarly, a vacuum exists naturally between laws (that set norms) and state guidance on laws (application). If we do not use debate to negotiate the contents of this vacuum, it will be filled with the bureaucracy of fear and even a state of exception. A vacuum demands to be filled. In both cases, we need to actively reclaim each ‘vacuum’ for discussion, debate and questioning in order to try and understand our current cultural imagination and develop a better one.
The impact of focused echocardiography using the Focused Intensive Care Echo protocol on the management of critically ill patients, and comparison with full echocardiographic studies by BSE-accredited sonographers
Authors: Hall David P , Jordan Helen , Alam Shirjel , Gillies Michael A
Published: March 2017

Introduction

Focused echocardiography is widely used to assist clinical decision-making in critically ill patients. In the UK, the Focused Intensive Care Echo protocol is recommended by the Intensive Care Society to ensure consistency of approach and guarantee training standards. Concerns remain about the reliability of information attained by non-expert clinicians in focused echocardiography, particularly when this is used to alter clinical management.

Methods

A prospective, observational evaluation of 60 consecutive patients undergoing Focused Intensive Care Echo studies in a single ICU.

Results

A complete Focused Intensive Care Echo study was possible in 43/60 scans (72%) and new diagnostic information obtained following 41/60 scans (68%), which lead to a change of clinical management in 28/60 (47%) of cases. In 24/60 (40%) of cases, a full transthoracic study was subsequently undertaken by a fully accredited sonographer. There were no cases where the results from the full study contradicted those from the limited Focused Intensive Care Echo study; additional diagnostic information was attained following 68% of full studies.

Conclusion

Focused echocardiography using the Focused Intensive Care Echo protocol is feasible and clinically useful in a high proportion of ICU patients. However, many still require additional expert echocardiographic assessment. Focused echocardiography delivered by non-experts is clinically useful in this setting but its limitations must be understood and access to expert assessment should be available.
Impact of health education based intervention on community’s awareness of dengue and its prevention in Delhi, India
Authors: Kusuma Yadlapalli S. , Burman Deepa , Kumari Rita , Lamkang Anjana S. , Babu Bontha V.
Published: March 2017

Dengue is endemic in India. The capital, Delhi, continues to witness a higher number of cases due to urbanization-related factors. This study is intended to implement health education towards prevention of dengue, and to assess its impact on people’s knowledge and practices related to causes and prevention of dengue among urban poor in Delhi. Pre- ( n = 484) and post- ( n = 496) intervention surveys from 15 sub-clusters from five slums/slum-like settlements in Delhi were carried out. Health education based intervention was carried out through partnership with the municipal bodies and non-governmental organizations. Socio-demographic characteristics of participants were similar in both surveys. Intervention resulted in significant increase in knowledge on cause, symptom perception and mosquito behaviour in terms of breeding and biting habits. Practice of personal protection measures increased significantly. The participation of people increased during intervention compared to the routine programme. Health education based interventions are instrumental in improving people’s knowledge and behaviour. Hence, routine health educational activities as a supportive strategy in the health system need to be strengthened. New integrated approaches such as eco-bio-social approaches with community participation are to be developed and tested in endemic settings like Delhi.