bluuebunny/crossref_metadata_2025 huggingface dataset:
Students’ Mathematics-Related Beliefs and Academic Performance
Authors: Hidayatullah Achmad
Published: February 2025

Az elmúlt évszázad során drámai mértékben megnőtt a tanulók matematika-tanulási teljesítményének hátterében álló tényezőkre vonatkozó kutatások száma. Bár nincs egyetlen válasz a matematikai teljesítmény mögött meghúzódó tényezők magyarázatára, kimutatták, hogy a matematikával kapcsolatos nézetek erős tényezők a diákok matematikai teljesítménye mögött. További kérdések merülnek fel azonban a tanulók nézeteivel és a matematikai teljesítményével kapcsolatban. (1) A személyes ismeretelméleti nézetek inkább tartalomspecifikusak vagy -általánosak? (2) Összefüggenek-e a tanulók matematikával kapcsolatos nézetei további személyes tényezőikkel? (3) Hogyan segítik elő a tanulók matematikai nézetei a matematika tanulása iránti elkötelezettségüket? (4) Hogyan hatnak egymásra a tanulók nézetei és hogyan határozzák meg egymást a matematika tanulásának egyéb nem kognitív tényezőivel? (5) Megjósolják-e a matematikai hiedelmek a tanulók matematikai tanulásban való részvételét? Ezekből a kérdésekből kiindulva az empirikus tanulmányaink a nézetek tartalomspecifikusságának és -általánosságának kérdését igyekeztek megközelíteni. Ezenkívül disszertációnk azt vizsgálta, hogy a matematika oktatásával kapcsolatos nézetek hogyan magyarázzák meg a többi nem kognitív tényezőt és a tanulók matematikai eredményeit. Az első vizsgálatot bemutató tanulmányunk empirikus bizonyítékot szolgáltat a tudásról alkotott nézetek különbségeire a különböző tartalmi területeken. A második vizsgálat empirikus bizonyítékot szolgáltatott a diákok matematikával kapcsolatos nézetrendszer-kérdőíveinek stabilitásáról és megbízhatóságáról indonéz kontextusban, és ez a tanulmány feltárta, hogy a diákok a matematikával kapcsolatos nézeteik tekintetében hogyan különböznek személyes tényezőik, például etnikai hovatartozásuk alapján. A harmadik vizsgálat feltárta, hogy a matematikai hiedelmek megmagyarázhatják a matematikai elkötelezettséget. A negyedik tanulmány feltárta, hogy a matematikával kapcsolatos nézetek és a szülők iskolai végzettsége hogyan függenek össze a matematikai eredmények meghatározásában a motivációval és attitűddel. Az ötödik vizsgálat feltárta, hogy Indonéziában a legtöbb diák hallgatólagosan úgy gondolja, hogy minden szöveges feladat megoldható rutinműveletek elvégzésével. E tanulmányok eredményei empirikus bizonyítékot szolgáltatnak arra vonatkozóan, hogyan lehet javítani a matematikaoktatás minőségét Indonéziában.
Neural network based clinical decision support system for the calculation the initial continuous subcutaneous insulin infusion settings
Authors: Laptev D. N. , Sorokin D. Y.
Published: February 2025

BACKGROUND: Despite existing recommendations for the initial calculation of insulin pump settings, the process is largely subjective and depends on the physician’s personal experience.

AIM: Development of a clinical decision support system (CDSS) that determines the initial settings of the insulin pump, which would have satisfactory agreement with the expert opinion of physicians.

MATERIALS AND METHODS: Neural network model developed using data (continuous subcutaneous insulin infusion (CSII) settings, age, weight, total daily dose, and HbA1c) from 2850 children with T1D who were switched to CSII and achieved optimal glycemic control according to glucose levels. CDSS utilizing the model implemented as a computer program in Python.

A prospective assessment of the agreement between the recommendations of the CDSS and the physician conducted on 35 data sets of children with T1D (median age 9.3 years [6.4, 11.5]), and 840 points for decisions were analyzed. 4 degrees of agreement were used: complete consistency, when the physicians agreed with the CDSS recommendations; partial consistency, when the physicians didn’t agree with the CDSS recommendations, but the difference was in the range of ±15%; complete inconsistency — the difference more than ±15%; acceptable consistency is the sum of full and partial consistency (± 15% error is clinically acceptable). The null hypothesis of the study was the absence of difference in consistency/inconsistency between physicians and the CDSS.

RESULTS: The frequency of full consistency between CDSS and physician recommendations for initiating insulin pump therapy is 29.8-43.8%, and inconsistency is 33.7-41.1%. Acceptable consistency is 58.9–66.3%. There were no significant differences in mean insulin pump parameters between CDSS and physicians.

CONCLUSION: The results obtained are consistent with previous studies. Proposed model demonstrates acceptable performance regarding initial CSII settings, without significant deviations between various parameters.
Clinical, bio­chemical and genetic characteristics of familial forms of type 1 diabetes
Authors: Zufarova I. M. , Laptev D. N. , Minniahmetov I. R. , Khusainova R. I. , Popov S. V. , Titovich E. V. , Eremina I. A. , Peterkova V. A.
Published: February 2025

BACKGROUND: Familial clustering of type 1 diabetes (T1D) highlights the importance of genetic and environmental factors in the pathophysiology of diabetes mellitus (DM). It could be the key to understanding of new immunological and genetic characteristics of T1D.

AIM: To study the clinical, biochemical, immunological and genetic characteristics of children with familial forms of T1D.

MATERIALS AND METHODS: A single-center cross-sectional study included 267 patients with familial T1D and 681 patients with sporadic T1D. Clinical and metabolic characteristics, beta cell autoantibodies and HLA class II genetics from patients with T1D hospitalized to Endocrinology Research Centre Moscow between 2016 and 2023 were analyzed.

RESULTS: The median age of onset of DM was significantly lower in children with familial T1D (5,2 [3,0; 8,0] vs 6,4 [3,6; 9,2], p<0,001). Children with sporadic T1D had diabetic ketosis or diabetic ketoacidosis (DKA) at presentation more frequently (90,3% vs 74%, p<0,001). Among the sib-pair groups 50,5% of first-affected siblings and 19,5% of second- and third-affected siblings had DKA at presentation, while in children from parent-offspring subgroup DKA episodes were observed in 21% of patients (p<0,001). IAA and GAD antibodies were more frequent in familial cases (p<0,013, p<0,003). In our groups, no significant differences in metabolic compensation of the T1D were found. HLA haplotypes associated with an increased disease risk DRB1*04-DQA1*03:03-DQB1*03:02 and DRB1*07-DQA1*02:01-DQB1*02:02 were more common in children with familial T1D (p<0.001 and p<0.001), while the protective haplotype DRB1*08-DQA1*04:01-DQB1*04:02 was more frequent in sporadic forms.

CONCLUSION: Due to our study familial forms of T1D are characterized by an earlier age of onset, a smaller risk of DKA at presentation, as well as features of the immunological profile and predisposing and protective HLA haplotypes presentation. We believe more studies are required in the future to look for risk factors and pathogenesis unserstanding.
Therapy of chronic skin ulcers in patients with diabetes mellitus using gene modifications of cell transplant
Authors: Abakushina E. V. , Vorobyova I. G. , Stepanova I. A. , Roumiantsev S. A.
Published: February 2025

In patients with diabetes mellitus (DM), systemic disorders in the body can cause a number of complications. One of the main complications is the disruption of wound healing processes, which can lead to the development of a diabetic foot ulcer (DFU) and subsequent amputation of the limb. Modified mesenchymal stem cells (GM-MSCs) - as a means of treating chronic wounds, reduce homing, have increased proliferative potential, therapeutic antitumor and pancreas-supporting properties. Native and genetically modified cells from allogeneic or autologous sources are studied for the treatment of DFU. The review presents the world experience of using stem cells in therapy in preclinical and clinical studies, collects data on the proposed technologies for the treatment of diabetic ulcers using GM-MSCs: combined transplantation of GM-MSCs with pancreatic islets, regulation of migration processes by changing the expression of integrins, blocking estrogen signals, increased expression of a number of genes, such as SDF-1α, c-JUN, MALAT1, to increase the viability and stimulate the proliferation of mesenchymal stem cells. Cells temporarily carrying therapeutic genetically engineered constructs show high efficiency of their use in preclinical trials.
Postprandial secretion of insulin and peptide YY when taking erythritol and sucrose
Authors: Silina N. V. , Mazurina N. V. , Ershova E. V. , Komshilova K. A. , Nikankina L. V. , Pershina-Milutina A. P. , Antonova K. V. , Troshina E. A.
Published: February 2025

AIM. To study the effect of the non-calorie sweetener erythritol and the combination of erythritol and sucrose on postprandial secretion of insulin and peptide-YY (PYY).

MATERIALS AND METHODS. A comparative study was conducted to assess the effect of erythritol, sucrose and a combination of erythritol and sucrose on postprandial glucose, IRI and PYY levels. The participants were selected from among healthy volunteers, aged 18 to 35 years. If the participants met the selection criteria, further stages of the study were carried out. During the study, each participant took a solution of sucrose 75 g, erythritol 75 g or a mixture of sucrose and erythritol (75 g and 25 g, respectively). Further determination of glucose and insulin was carried out every 30 minutes, so glucose, insulin and PYY values were determined initially and at the 30th, 60th, 90th and 120th minutes.

RESULTS. Data were obtained confirming the absence of the effect of erythritol on postprandial secretion of insulin and glucose. In our work, we also demonstrated a decrease in postprandial glycemia when taking sucrose and erythritol together. Sucrose and erythritol equally stimulated PYY secretion.

CONCLUSION. Our data show that erythritol can be considered as an optimal sugar substitute in people with impaired carbohydrate metabolism and obesity.
“Além do olhar petrificante"
Authors: Zukoski Ana Maria Soares , Esteves Natacha dos Santos , Coqueiro Wilma dos Santos
Published: February 2025

O presente estudo, partindo do romance O olhar petrificante: a história de Medusa (2023), de Nathalie Haynes, apresenta uma revisitação ao mito da Antiguidade Clássica e uma perscrutação sobre como foi criado o monstro Medusa. Tendo como corpus de análise uma obra contemporânea, cuja premissa básica é humanizar e evidenciar como a personagem foi vítima de diversas violências, o corrente estudo desnuda a influência do patriarcalismo na criação do arquétipo de monstro e, assim, convida ao questionamento sobre quem são, de fato, os monstros.
Barrier properties of film eco-materials based on emulsions loaded with sodium alginate
Authors:   South Ural State University, Malinin Artem , Tsaturov Aram ,   South Ural State University, Chemek Marouane ,   South Ural State University, Entonu Moses Edache ,   South Ural State University
Published: February 2025

Environmental problems associated with household waste today do not lose their relevance. All over the world, scientists are developing formulations and technologies for produc-ing biodegradable materials alternatives to plastics, including from plant waste, but there is no ready-made solution. The main conditions for the effective replacement of plastics with biode-gradable materials (films) are: high barrier properties combined with plasticity and safety during biodegradation in compost systems for the environment. To improve the barrier properties of an organic biodegradable film, our research proposes the use of direct oil-in-water emulsions loaded with sodium alginate in the material matrix, which determined the purpose of the study. Direct oil-in-water emulsions based on sodium alginate obtained from brown Arctic algae kelp of different concentrations (0.5; 1.0; 1.5 %) on the barrier properties of biodegradable composite packaging (film). As part of the study, 4 film samples were prepared. During the study, film samples were as-sessed for such indicators as thickness, water content, water solubility, opacity, vapor permeability and water absorption and determination of the migration of components into food simulants. As a result of processing experimental data from samples of biodegradable eco-material, the best per-formance was established for samples with the addition of an emulsion loaded with sodium algi-nate in an amount of 1.5 %. The developed biodegradable material can be used to create composite packaging materials and non-durable products to solve environmental problems.
Ozonated water treatment for sustaining quality attributes and prolonging shelf life in grapes
Authors: Chinnasamy K , Balachandran A , Borthakur P , Venkatachalam S , Kolandasamy P
Published: February 2025

Grapes (Vitis vinifera), a subtropical fruit crop, are highly valued for their nutritional composition and global economic importance, both as fresh consumption and processed forms. However, postharvest quality loss, primarily caused by grey mould (Botrytis cinerea), microbial decay and physiological weight loss, poses a significant challenge to grape storage and marketability. This experiment was designed to evaluate the efficacy of postharvest ozonated water treatment on quality attributes and extending the shelf life of grapes. Grape bunches were subjected to four treatments: control (no dip) and immersion in 0.3 ppm ozonated water for 5, 10 and 15 min, followed by storage at 4±2°C and 90 % relative humidity (RH). Results indicated significant improvements in key quality parameters for grapes treated with ozonated water, particularly with the 15 min treatment (T4). These bunches exhibited higher titratable acidity (0.24 %), ascorbic acid content (1.81 mg/100 g), and firmness (4.80 N) while exhibiting 21.82 % lower physiological weight loss compared to the control. Ozonated water treatment also minimized berry abscission (3.77 %) and maintained sensory properties. The sugar-acid ratio was highest (84.72) in 5 min treatment group (T2) on the 36th day of storage, enhancing flavour attributes. Significantly, T4 extended the shelf life of grapes to 39.84 days, nearly five days longer than the untreated grapes. This study demonstrated the potential of ozonated water as an eco-friendly, residue-free technology for postharvest preservation, offering a safer alternative to chemical fumigation. The findings support the integration of ozonated water treatments into grape postharvest management practices to enhance quality, storability and consumer acceptability.
A method for MRI‐guided bronchoscopy to identify obstructed airway segments
Authors: Mummy David G. , McIntosh Marrissa J. , Carey Katherine J. , Kehoe Shannon , Esnault Stephane , Johansson Mats W. , Evans Michael D. , Sorkness Ronald L. , Schiebler Mark , Jarjour Nizar N. , Denlinger Loren C. , Fain Sean B.
Published: February 2025

Bronchoscopy is not conventionally guided by prior knowledge of segmental airway obstruction. Hyperpolarized gas magnetic resonance imaging (MRI) ventilation abnormalities and computed tomography (CT) air trapping are related to lung function and asthma severity but have not been used to target segmental inflammation and remodeling. We evaluate the feasibility of using bronchoscopy guided by 3He MRI and CT to reveal differences in inflammatory response, morphology, and cellular activity in poorly‐ (defect) versus well‐ventilated (control) lung regions. Eleven participants (5 female; age, 22.8 ± 3.4 years; 9 asthma) who experienced a cold with increased lower airway symptoms underwent 3He MRI and/or CT at least 6 weeks after recovery. Differences between defect and control regions were compared. In defect as compared to control sites, bronchoalveolar lavage neutrophils (p = 0.06) and granulocytes (p = 0.08) trended towards an increase; inflammatory mediators (i.e., 15‐epi‐LXA4, LXA4) were also significantly different (p < 0.05) between sites. Correlations were observed between macrophages, neutrophils, and eosinophils with inflammatory mediators (i.e., 15‐epi‐LXA4, LXA4, LTB4). Correlations were observed for macrophages and neutrophils with 15‐epi‐LXA4, and eosinophils with LXA4 and leukotriene B4. Basement membrane wall thickness was similar for defect versus control sites (p = 0.9). These results support the feasibility of image‐guided methods to identify airway obstruction phenotypes.
A corpus-based behavioral profile analysis of polysemy and antonymy: the case of the ancient Greek size adjectives mikrós and mégas
Authors: Georgakopoulos Thanasis , Lavda Marialena
Published: February 2025

This article explores the semantic relationships between the antonymous adjectives mikrós (‘small’/‘little’) and mégas (‘big’/‘large’) in Classical Greek. Adopting a cognitive and usage-based perspective, the study applies the Behavioral Profile approach to investigate the polysemy of these adjectives and to assess the strength of their antonymic relationship. Specifically, it aims to determine whether the functional similarity among antonymous words is greater or lesser than that found within the senses of polysemous words. By focusing on how antonymous senses of different lexemes cluster together in a joint network, the study examines the extent to which antonymy, rather than polysemy, governs the organization of these senses. The analysis points to an upgraded role of antonymy in semantic structure.
The necessity of construct and external validity for deductive causal inference
Authors: Esterling Kevin M. , Brady David , Schwitzgebel Eric
Published: February 2025

The Credibility Revolution advances internally valid research designs intended to identify causal effects from quantitative data. The ensuing emphasis on internal validity, however, has enabled a neglect of construct and external validity. We show that ignoring construct and external validity within identification strategies undermines the Credibility Revolution’s own goal of understanding causality deductively. Without assumptions regarding construct validity, one cannot accurately label the cause or outcome. Without assumptions regarding external validity, one cannot label the conditions enabling the cause to have an effect. If any of the assumptions regarding internal, construct, and external validity are missing, the claim is not deductively supported. The critical role of theoretical and substantive knowledge in deductive causal inference is illuminated by making such assumptions explicit. This article critically reviews approaches to identification in causal inference while developing a framework called causal specification. Causal specification augments existing identification strategies to enable and justify deductive, generalized claims about causes and effects. In the process, we review a variety of developments in the philosophy of science and causality and interdisciplinary social science methodology.
Role of Phase Change Material in Implementing Renewable Energy for Small Scale Residential Cooling Appliances
Authors: Aslam Jamal , Santhaappan Joseph Sekhar
Published: February 2025

One of the main solutions to energy and environmental problems is to offer cooling using renewable energy sources (RES). However, in the utilization of RES, appropriate energy storage systems are required to overcome the intermittency issues of RES. Phase change materials (PCMs) play a vital role in implementing RES in low-temperature cooling applications, and several studies have reported their advantages and limitations. This review article aims to provide a comprehensive evaluation of current studies on PCM selection, applications, advantages, and the scope of further research to effectively utilize RES for cooling applications. We reviewed recent articles related to theoretical, numerical, and experimental studies on PCM-based solar cooling systems, including transport refrigeration, food outlet chilling, and commercial building cooling. A rigorous examination and summarization of the literature provides a comprehensive overview of the PCM's involvement in enhancing the performance of refrigeration systems. Compared to conventional systems, the inclusion of PCH enhances off-time temperature maintenance by more than six times, reduces pulldown time by up to 78%, and results in energy savings of up to 18.5%. Furthermore, PCM allows the refrigerators to work at the required temperature even after sunshine hours with 8–15% less energy consumption and without battery storage. However, further studies using the recently developed PCMs can determine the performance of system components and their potential application in various sectors of the refrigeration industry in the coming years.
Vehicle-to-Vehicle Communication: A Review of Efficiency, Communication Medium and Action Signal
Authors: Anaz Anizan Nur Izzati , Ahmat Ruslan Fazlina , Abdul Razak Noorfadzli , Abdul Aziz Mohd Azri , Johari Juliana
Published: February 2025

In an era marked by rapid advancement in technology, transportation systems are experiencing a revolutionary transformation. Vehicle-to-Vehicle (V2V) communication stands at the forefront of this transformative movement, with the potential to significantly change the ways how vehicles interact with one another and their surrounding environment. This newly developed technology has the capacity to significantly improve road safety, traffic efficiency, and every aspect of the driving experience. Thus, a review of V2V communication based on its safety, efficiency of traffic on the road, the medium of communication and the action signal have been made. The purpose of the review on this technology is to examine the possibility of enhancing safety measures that may include walking, motorcyclists, cyclists, and drivers on the road. A comprehensive review of publications about safety, technology for communication, and signal reception in vehicles was conducted, along with an analysis of the articles that followed. Notably, the quest encompassed three prominent databases – IEEE Xplore, ScienceDirect, and Web of Science – covering the period from 2002 to 2023. These repositories were deemed adequately comprehensive to envelop our literature review. Through the application of predefined criteria for inclusion and exclusion, a total of 125 articles were curated. Among this compilation, a majority (63 out of 125) were dedicated to studies centered around V2V communication systems. Furthermore, a significant subset (44 out of 125) revolved around tangible endeavors directed at the advancement of V2V communications. The remaining fraction (18 out of 125) comprised articles offering comprehensive assessments and survey analyses. Multiple investigations were conducted with a focus on automating the detection of V2V communications and their respective subcategories, all geared towards the enhancement of detection accuracy. Therefore, this systematic review is intended to provide pathways for researchers and encourage their motivation to address the identified problems and gaps.
Iatrogenic Obturator Hernia with Ureter as Content – a Case Report
Authors: Alagappan Alamelu , Nayak Manoj Kumar , Tripathy Sambit , Sahoo Biswajit , Sahani Debabrata
Published: February 2025

A male in his early 70s presented with complaints of bilateral flank pain for seven months, hematuria for 2 days along with the passage of clots associated with an increased frequency of urination and nocturia. The patient had a history of deep vein thrombosis and was on anticoagulation. On ultrasound, multiple calculi with posterior acoustic shadowing were seen in bilateral kidneys, corroborated by Computed Tomography (CT) urography. Laser lithotripsy with DJ stent placement was conducted. The follow-up CT urography showed an inferiorly displaced DJ stent within the right distal ureter and the DJ stent herniating through the right obturator foramen. The right-sided DJ stent was removed after a month. For obturator hernia, the patient is being kept in the follow-up. This case report reviewed the literature and discussed the diagnosis and complications associated with the obturator hernia with the ureter as the content.
П’єзоелектричний відгук полі (L-молочної кислоти) α-форми на механічно напружений стан
Authors: Zadorozhnyi V.M. , Balabai R.M. , Bondarenko O.O.
Published: February 2025

У роботi дослiджено п’єзоелектричнi ефекти в полiмерi (L-молочна кислота) при механiчному впливi методами теорiї функцiонала густини та псевдопотенцiалу на основi власного програмного коду. Розраховано просторовi розподiли густини валентних електронiв, густини електронних станiв, кулонiвських потенцiалiв у рiзних напрямках фрагмента полiмеру PLLA та зарядових станiв його окремих атомiв. Встановлено, що лише один фрагмент полiмерного ланцюга дозволяє визначити характер зарядової поляризацiї валентних електронiв та iонiв при механiчнiй деформацiї.
Ґратки острівців електронно-діркової рідини в дихалькогенідах при оптичному накачуванні
Authors: Chernyuk A.A.
Published: February 2025

Виконано чисельне моделювання формування електронно-дiркової рiдини у випадку однорiдного свiтлового опромiнення дихалькогенiдiв перехiдних металiв типу MoS2 та MoTe2. Дослiджено кiнетику захоплення екситонiв острiвцями та обчислено розподiл густини екситонiв навколо острiвцiв, враховуючи кореляцiю в положеннях острiвцiв у газi екситонiв та межовi умови при рiзнiй формi однорiдного накачування. Оцiнено розмiри острiвцiв електронно-дiркової рiдини. Встановлено оптимальне просторове розмiщення острiвцiв електронно-дiркової рiдини та залежнiсть утвореної структури вiд параметрiв системи.
Direct Oral Anticoagulant Use in Older Adults with Atrial Fibrillation: Challenges and Solutions
Authors: Bhandari Monika , Pradhan Akshyaya , Vishwakarma Pravesh , Di Renzo Laura , Iellamo Ferdinando , Ali Wahid , Perrone Marco Alfonso
Published: February 2025

AF is the most common arrhythmia in clinical practice, with a large preponderance in the older (>75 years) adult population. Stroke is the most feared complication of AF, with huge corresponding morbidity and mortality. Anticoagulation is the mainstay for stroke prevention in AF, but is commonly underutilised in clinical practice due to the fear of intracerebral bleeding. Bleeding is the primary concern in older patients with conventional vitamin K antagonist use. Direct oral anticoagulants (DOACs) have been used for a decade in clinical practice and have been found to reduce major bleeds. The advantages of DOAC use in older patients include obviating the need for intermittent international normalised ratio monitoring, fewer drug interactions and reduction in intracerebral haemorrhage. The disadvantages of DOAC use include older patients having to take multiple doses per day and a lack of a universal antidote, as opposed to vitamin K antagonists. However, a lack of head-to-head trials among DOACs and specific randomised controlled trials in older patients preclude a definite conclusion regarding the ideal DOAC that should be used in the older population. Factor XI inhibition is an emerging approach for oral anticoagulation that holds promise for dissociating thrombosis from haemostasis. This provides an additional avenue for reducing bleeding in the older adult population.
Antioxidant effects of sorghum 3-deoxyanthocyanin on chilled pork meat
Authors: Zang L. , Jin X.-P. , Xu Y. , Zhang D. , Liang R.-R. , Wu Y.-Y.
Published: February 2025

Sorghum is rich in phenolic compounds, such as phenolic acids, flavonoids, and anthocyanins. Among them, 3-deoxyanthocyanin (3-DXA) is a rare subclass of anthocyanins, which has not only antioxidant, anti-inflammatory, and anti-cancer functions, but also good thermal stability, colouring effect, as well as unique properties of acid and alkali resistance. In this study, we extracted 3-DXA from sorghum grains and analysed its composition. Component analysis indicated that the purified 3-DXA mainly contained apigenin and luteolin, with the contents of 1.46 μg g−1 and 1.38 μg g−1, respectively. The antioxidant activity of 3-DXA in vitro was between vitamin C (Vc) and rutin based on 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) radical scavenging rate and Fe3+ reducing power. Different concentrations of purified 3-DXA were applied to pork meat stored at 4 °C. After 11 days of storage, physiological and biochemical indices related to antioxidant and meat quality were determined. The results showed that 0.02% 3-DXA had the best antioxidant effects on pork meat within 11 days of storage at 4 °C based on a* value, pH value, purge loss, TBARS value, and total number of bacteria. The results in this study are helpful for the application of 3-deoxyanthocyanin to maintain the quality of pork meat and prolong the storage time at 4 °C.
Creation of a general mathematical model of Torsen T-2 differential units for kinematical analysis, geometric design and CAD modelling
Authors: Bodzás Sándor , Tiba Zsolt
Published: February 2025

The power can be taken from the ICE crankshaft is a function of the continuously changing adhesion coefficient between the tire and the road surface and the normal force of the wheel. In order to maximize vehicle dynamic performance, Torsen differentials were developed change the power transmission ratio between the wheels or axles depending on the tractive force can be transmitted. The Torsen T-2 differential having internal kinematic ratio i = −1, can be used both as a front and rear as well as a central differential. The torque ratio between the axles connected via Torsen T-2 differential is ensured by the high internal mechanical friction, can be derived from the axial tooth force component of the helical gear drive applied.

The aim of this study is to create a general mathematical model of the Torsen T-2 standard construction. Using this model enables to perform a detailed kinematic analysis of the operation of the entire mechanism. This model will be created by the motion of the gears since coordinate systems are ordered to each moving gears. Based on the Connection I statement the conjugated gear profiles of the gear pairs can be determined by mathematical and computational ways. After that, the CAD models of the gears can be created using 3D software for further finite element analysis. These CAD models are also required for computer-aided manufacturing (CAM) and CNC programming. We prove the usefulness of the model in the case of creating a concrete geometric facility produced by 3D printing.
Applied analysis of the legal and economic context of freedom of contract – A case study
Authors: Török Éva
Published: February 2025

This paper examines a civil law legal institution, contractual freedom, from an economic perspective in connection with economic freedom. The paper investigates the following cases, as the economic freedom of a given national economy is measured in four main areas: the size of government, legal system and property rights, sound money, freedom to trade internationally and regulation of credit, labour markets and business life. In the Economic Freedom of the World 2022 Annual Report, Hungary ranked 55th in the global ranking with an overall score of 7.12, compared to 44th in 2000, with a score of 7.03. Neither the change in score nor the ranking is significant. However, the fact that the country has fallen further behind in this international ranking is not encouraging.
Eviscerações são evitáveis?
Authors: TOMASI JULIO FERNANDES , TOLFO FABIELLE MENEZES , CONSTANTINO LAIS MADEIRA , CACCIATORI FELIPE ANTÔNIO
Published: February 2025

RESUMO Introdução: A incidência de eviscerações é de 3,5% na literatura. O uso de telas profiláticas em pacientes com alto risco de evisceração tem sido estudado. O objetivo deste estudo é avaliar as características dos pacientes submetidos à ressutura da parede abdominal devido evisceração e verificar o benefício do uso de tela profilática nesta amostra. Métodos: Trata-se de estudo retrospectivo do tipo coorte, que analisou os prontuários de pacientes submetidos ao procedimento de ressutura de parede abdominal entre janeiro de 2010 e dezembro de 2023 em um hospital terciário. Os critérios de inclusão foram pacientes submetidos à ressutura de parede abdominal no hospital de estudo, com cirurgia índex no mesmo hospital e acesso mediano. Pacientes menores de 18 anos, pacientes submetidos a cirurgias videolaparoscópicas e acessos não medianos foram excluídos. O escore de risco para deiscência de aponeurose de Rotterdam, modificado por Lima, foi utilizado como parâmetro. Resultados: A amostra final de 252 pacientes foi composta por 74,2% de homens. A mediana de idade foi de 64 anos e a mediana de IMC foi de 24,3kg/m2. A mediana do intervalo de dias entre a cirurgia e a ressutura foi de 8 dias. A hemoglobina mediana foi de 11,1g/dL. A prevalência, na amostra, de neoplasia, tabagismo e DPOC foi de 47,2%, 32,1% e 13%, respectivamente. Cirurgias eletivas foram 58,8%. Conclusão: Concluiu-se que, utilizando o escore de Rotterdam modificado, dos 227 pacientes, 164 (72,2%) teriam recebido tela profilática, o que, potencialmente, teria evitado a evisceração.
Are eviscerations preventable?
Authors: TOMASI JULIO FERNANDES , TOLFO FABIELLE MENEZES , CONSTANTINO LAIS MADEIRA , CACCIATORI FELIPE ANTÔNIO
Published: February 2025

ABSTRACT Introduction: The incidence of eviscerations is 3.5% in the literature. The use of prophylactic meshes in patients at high risk of evisceration has been studied. The objective of this study is to evaluate the characteristics of patients undergoing abdominal wall resuturing due to evisceration and verify the benefit of using prophylactic mesh in this sample. Methods: This is a retrospective cohort study, which analyzed the medical records of patients who underwent abdominal wall resuturing procedures between January 2010 and December 2023 in a tertiary hospital. The inclusion criteria were patients who underwent abdominal wall resuturing in the study hospital, with index surgery in the same hospital and median access. Patients under 18 years of age, patients undergoing laparoscopic surgery and non-median access were excluded. The Rotterdam risk score for aponeurosis dehiscence, modified by Lima, was used as a parameter. Results: The final sample of 252 patients was made up of 74.2% men. The median age was 64 years and the median BMI was 24.3kg/m2. The median number of days between surgery and resuturing was 8. The median hemoglobin was 11.1g/dL. The incidence of neoplasia, smoking and COPD was 47.2%, 32.1% and 13% respectively. Elective surgeries were 58.8%. Conclusion: It was concluded that, using the modified Rotterdam score, of the 227 patients, 164 (72.2%) would have received prophylactic mesh, which potentially would have prevented evisceration.
História Medieval e Ciência de Dados: A inovação na produção de conhecimento histórico auxiliada pelas tecnologias da informação
Authors: RIBEIRO DA SILVA THIAGO JUAREZ , DINIZ MÁRCIO AUGUSTO
Published: February 2025

RESUMO O artigo visa demonstrar como a interconexão entre História Medieval e Ciência de Dados pode contribuir para o avanço dos estudos históricos. Para tanto, apresentaremos os produtos resultantes da pesquisa de Pós-Doutorado intitulada “O pobre e a pobreza na Alta Idade Média (séculos VI-IX): estudo linguístico e histórico”, acerca da pobreza entre os séculos VI e IX no Ocidente continental europeu: i) um banco de dados sobre o léxico da pobreza na Alta Idade Média, disponibilizado para consulta pública online em https://thirisi.github.io/Projeto-PaupeR/; ii) o programa PaupeR, uma nova ferramenta desenvolvida em linguagem R, para geração e consolidação dos dados de forma que os tornem possíveis de ser explorados em diferentes perspectivas estatísticas; e iii) um repositório público com todas as informações geradas por esta pesquisa, onde os visitantes podem acessá-las, baixá-las e copiá-las, disponível no seguinte endereço eletrônico: https://github.com/thirisi/Projeto-PaupeR. Com isso, esperamos contribuir não somente para a compreensão do tema da pobreza no período recortado, mas também lançar bases para novas explorações dos dados, novas interpretações e novas metodologias de análise.
Desodorante tópico de oxibutinina para hiperidrose axilar: efeito local ou sistêmico? Fundamentação e desenho do estudo de fase II today
Authors: Neves Samantha , Volpiani Giuliano Giova , Paganotti Alexia , Menegueti Felipe , Boix Ricardo Sanchez , Caffaro Roberto Augusto , Santos Vanessa Prado dos , Ramacciotti Eduardo
Published: February 2025

Resumo Os anticolinérgicos melhoram a qualidade de vida com redução da sudorese em pacientes com hiperidrose, mas permanece incerto se a aplicação tópica exerce efeitos locais ou sistêmicos. O objetivo principal deste estudo é avaliar o impacto da oxibutinina tópica na hiperidrose axilar. Vinte pacientes com hiperidrose axilar serão randomizados em três grupos. O Grupo A receberá 2,5 mg de oxibutinina oral com diferentes posologias do primeiro ao 35º dia. O Grupo B receberá um placebo tópico na forma de spray, e o Grupo C receberá um spray de oxibutinina a 10%, com duas borrifadas em cada axila duas vezes ao dia por 35 dias (produto em investigação). O desfecho primário será a avaliação da eficácia do spray tópico de oxibutinina, avaliada pelo número de pacientes que apresentam melhora na gravidade da condição. O estudo TODAY mostrará evidências sobre os efeitos da oxibutinina tópica, avaliando seu impacto na hiperidrose axilar.
Effects of co-culture with multipotent endometrial stromal cells during in vitro production of bovine embryos
Authors: Camargo G.C. , Janini L.C.Z. , Cintra L.N. , Maciel A.P. , Sudano M.J. , Lobo A.C.M. , Landim-Alvarenga F.C.
Published: February 2025

ABSTRACT In vitro embryo production (IVP) protocols generally use supplementation with fetal bovine serum (FBS) in its culture media. Although it contains essential nutrients and growth factors for the embryo, exposure to serum can affect embryonic morphology and biochemistry, in addition to being possibly related to increased fetal weight at birth. In this sense, multipotent stromal cells (MSCs), given the wide range of secreted factors, could help improve IVP protocols. This study verified whether cell proliferation factors secreted by multipotent stromal cells obtained from endometrial tissue (eMSCs) stimulate the development and production of better quality embryos. For that purpose, bovine embryos produced in vitro were co-cultured with eMSCs and evaluated for cleavage index and blastocyst formation, as well as total cell count, trophoblast cell count and apoptotic cell count. It is concluded that the production of bovine embryos associated with co-culture with eMSCs presented similar results to the use of traditional media, showing an improvement regarding the total number of cells, in which the embryos cultivated in the presence of eMSCs and absence of FBS presented a higher number of total cells than those cultured in the absence of eMSCs and FBS.
Carbohydrate fractionation and nitrogen compounds, mineral status, and gas production in arboreal cotton and cactus silages
Authors: Araújo C.A. , Lima R.S. , Oliveira G.F. , Nascimento D.B. , Campos F.S. , Gois G.C. , Silva T.G.F. , Magalhães A.L.R. , Araújo G.G.L.
Published: February 2025

ABSTRACT The aim of this study was to evaluate the fractionation of carbohydrates and nitrogen compounds, mineral status, and in vitro gas production of arboreal cotton silages combined with different cactus levels (0, 150, 300, 450 and 600g.kg-1 on dry matter basis), distributed in a completely randomized design with 5 treatments and 4 replicates. For carbohydrate fractionation, there was an increase in fraction B2, and a decrease in fraction C (P<0.05). In nitrogen compounds, there was a decrease in B3 and C fractions (P<0.05). A quadratic effect was observed on mineral matter, crude protein, nitrogen, potassium and latency phase (P<0.05). Under the experimental conditions, the use of cactus in arboreal cotton silages increases the levels of minerals, carbohydrates and gas production in the silage, however, it reduces the protein content in the silages when cactus levels above 150 g.kg are inserted in arboreal cotton silages.
Patient-centered factors associated with orthodontic treatment success: a scoping review
Authors: Santana Lucas Garcia , Gatti-Reis Luisa , Paiva Saul Martins , Ramos-Jorge Maria Letícia , Marques Leandro Silva
Published: February 2025

Abstract The aim of this systematic review was to synthesize the available literature on pretreatment factors, from a patient-centered perspective, that predict successful orthodontic treatment. Systematic and unrestricted searches were conducted across the electronic MEDLINE, Embase, Web-of-Science, Scopus, Cochrane Library, and LILACS/Bireme databases. Grey literature was also searched to identify potential studies. Qualitative assessments of the role of patient-centered pretreatment factors in orthodontic treatment success (adherence, satisfaction, and discontinuation rates) were evaluated and synthesized. Study selection and data extraction were performed independently by two reviewers. A total of sixteen studies were included. Three main domains related to the patient emerged as positive predictors of orthodontic treatment success: previous patterns of social behavior, attitudes of parents/caregivers, and reasonable motivation. Certain personality traits were associated with both positive and negative levels of adherence and treatment satisfaction. The evidence did not support the notion that the impact of malocclusion on aesthetic self-perception could serve as an indicator of cooperation, satisfaction, or discontinuation rates related to orthodontic treatment. Positive social behavior patterns and parental/caregiver attitudes, along with realistic prior motivation toward treatment goals, were found to be reliable predictors of orthodontic treatment success. Additionally, some personality traits were found to be associated with successful treatment outcomes. However, the evidence did not support the impact of malocclusion on self-perceived aesthetics as an indicator of compliance and satisfaction levels with orthodontic treatment.
Structural equation modeling of the association between oral health literacy and dental caries in children
Authors: LIMA Larissa Chaves Morais de , NEVES Érick Tássio Barbosa , PERAZZO Matheus França , BERNARDINO Veruska Medeiros Martins , SILVA Samara Ellen da , PAIVA Saul Martins de , FERREIRA Fernanda de Morais , GRANVILLE-GARCIA Ana Flávia
Published: February 2025

Abstract The aim of this study was to explore the association between oral health literacy (OHL) and dental caries in children, evaluating the direct and indirect effects of brushing frequency, obesity, and socioeconomic factors. A cross-sectional study was conducted with 739 schoolchildren aged eight to ten years and their parents/caregivers who answered a questionnaire addressing sociodemographic characteristics and oral hygiene habits as well as the OHL – Adult Questionnaire. Cavitated dental caries in the schoolchildren was evaluated using International Caries Detection and Assessment System criteria. Descriptive analysis was performed, followed by structural equation modeling into the theoretical model (95% CI). Goodness-of-fit indices were considered satisfactory (root mean square error of approximation < 0.06; comparative fit index > 0.90–0.95; standardized root mean square residual < 0.10 and Tucker-Lewis Index > 0.90–0.95). Mother’s age (standardized coefficient [SC]: -0.08; p < 0.01), caregiver’s schooling (SC: -0.22; p < 0.01), obesity (SC: 0.13; p < 0.01), and brushing frequency (SC: -0.09; p < 0.01) had a direct effect on dental caries, whereas OHL had an indirect influence on the outcome. Mother’s age, caregiver’s schooling, brushing frequency, and obesity directly affected the occurrence of cavitated carious lesions in children in the mixed dentition phase, whereas OHL had an indirect effect on this clinical outcome.
Bone mineral density in patients using aromatase inhibitors: a clinical, nutritional, and quality of life assessment
Authors: SOUZA Alessandra Figueiredo de , BARRA Sâmila Gonçalves , ROCHA Amanda Leal , BEMQUERER Larissa Marques , OLIVEIRA Sicilia Rezende , CARVALHO Larissa Nayane , AMARAL Tânia Mara Pimenta , BRASILEIRO Claudia Borges , COSTA Fernando Oliveira , SOUZA Leandro Napier , CAMARGOS Bruno Muzzi , LIMA Enaldo Melo de , FERREIRA Adaliene Versiani Matos , HEREDIA Joyce Elisa , OLIVEIRA Marina Chaves de , MACARI Soraia , ABREU Lucas Guimarães , MESQUITA Ricardo Alves , SILVA Tarcília Aparecida
Published: February 2025

Abstract The use of aromatase inhibitors (AIs) leads to an imbalance in bone remodeling and can cause osteoporosis. This study aimed to identify clinical, periodontal, nutritional, and biochemical determinants of bone mineral density (BMD) changes in patients using AIs. The sample consisted of 40 women using AIs and 32 controls. BMD was assessed by dual X-ray absorptiometry (DXA). Data on nutritional, anthropometric, oral and periodontal status, and oral health-related quality of life (OHRQoL) were collected. Cytokines and adipokines were quantified in saliva and serum. Thirty-nine of the 72 women had low BMD, with a similar distribution in the control and AIs groups. BMD was lower in older women using AIs (p = 0.009) and in smokers (p = 0.034). Anthropometric assessment demonstrated that women with low BMD who used AIs had lower weight (p = 0.028). Although the frequency of periodontitis was similar in all groups, higher IL-6 (p = 0.004), IL-1β (p = 0.002), and IL-33 (p = 0.006) levels were associated with poor periodontal status. Women who used AIs were 1.18 times more likely to report better OHRQoL than controls. While advanced age, smoking, and lower weight are factors associated with low BMD, the use of antiresorptive agents was a protective factor for maintaining BMD in women using AIs.
NOVOS TESTES DE CULTIVO DE FUNGOS UTILIZADOS EM CONTROLE BIOLÓGICO USANDO MEIOS DE CULTURA NATURAIS LÍQUIDOS
Authors: Alvarenga Ana R. M. , Cruz B. P. Bastos , Oliveira D. A. , Silveira A. P. , Bulisani E. A.
Published: February 2025

RESUMO O estudo foi realizado com o objetivo de comparar o desenvolvimento e a esporulação dos fungos Metarhizium anisopliae (Metsch.) Sorokin), Beauveria bassiana (Bals.) Vuill. e Hansfordia pulvinata (Berk & Curt.) Hughes, em meios de cultura obtidos por maceração de sementes de três variedades de feijão de mesa (Carioca, Carioca 80 e Jalo) e de feijão Guandú, soja e grão de bico. Os substratos foram obtidos usando 50 g de matéria prima para 500ml de água destilada. A esterilização foi feita em autoclave por 30 minutos. Foi constatado que os fungos M. anisopliae e B. bassiana alcançaram maiores índices de esporulação que H. pulvinata em GuandÚ e grão de bico. Carioca 80 ofereceu boa produtividade de conídios para os três fungos. Jalo teve destaque somente para H. pulvinata.
CONTRIBUIÇÃO AO ESTUDO DE HYPOTHENEMUS HAMPEI (FERRARI, 1867)
Authors: Batista Filho A. , Abrahão J. , Cruz B. P. Bastos
Published: February 2025

RESUMO Estudando a broca de café Hypothenemus hampei, foram realizados em março de 1988, no município de Caconde SP, levantamentos populacionais que evidenciaram a importância da manifestação tardia da praga (16% dos frutos). Para tal, foram instaladas duas armadilhas de etanol, testado como atraente, que permitiram a captura de 112 insetos. Posteriormente o fungo Beauveria bassiana foi também colocado nas armadilhas. Diariamente, metade das brocas capturadas eram liberadas no campo como agente de epizootias e a outra metade conduzida ao laboratório para comprovação da eficiência do patÓgeno (100% mortalidade). Amostras do microrganismo, após 15 dias, mantiveram os conídios com poder germinativo de 98%. Em laboratório foi observado que: 1) Frutos de café tratados com B. bassiana e espalhante adesivo, fornecidos a indivíduos da broca, causaram 90% de mortalidade; 2) Exemplares do coleóptero foram alimentados com dois tipos de dietas artificiais, sendo que uma delas favoreceu a reprodução e o desenvolvimento das formas imaturas.