bluuebunny/crossref_metadata_2025 huggingface dataset:
High Axial Myopia in Neurofibromatosis Type 1
Authors: Garg Rajiv , Madan Siddharth , Yadav Nisha , Yadav Rekha
Published: November 2023

Background:

Clinicians must be aware of phenotypic variability in neurofibromatosis type 1 (NF 1) presentations. There is perhaps a limited understanding on progression of NF 1 in prepubertal years and the subsequent threat to vision. Progressively increasing myopia may go unnoticed under a severely ptotic eyelid that gathers attention, due to a disfiguring mass in patients with NF 1. High myopia may result in recalcitrant amblyopia if not tackled early with multidisciplinary management.

Clinical Description:

A 12 year old girl had a history of progressively increasing left upper eyelid ptosis due to an upper eyelid mass, first noticed at the age of 1 year and eventually resulted in severe ptosis by the age of 5 years. However, this went unnoticed until she was diagnosed with NF 1 at the age of 12 years. Best corrected visual acuity was 6/6 (Plano) in the right eye (OD) and counting finger 2 m with − 15.0 diopter spheres in the left eye (OS). Peripheral fundus examination was normal in both eyes. Levo elevation and abduction were limited OS. Hypotropia, pulsatile proptosis, and depression of the globe were clinically attributable to enlargement of orbital tissues and lid problems. Contrast enhanced computed tomography scan revealed plexiform NF with extraconal extensions. Axial length was 21.94 mm OD and 28.92 mm OS. B scan ultrasound revealed a posterior staphyloma OS.

Management:

The patient underwent a debulking surgery of the eyelid mass which on histopathological examination confirmed plexiform NF. Surgery resulted in a cosmetic reduction in ptosis; however, any intervention was relatively too late to rehabilitate the left eye.

Conclusions:

Eye care certainly has its regional differences. High axial myopia may result in low VA and recalcitrant amblyopia that may go unrecognized and comes with management challenges to the attending ophthalmologist and allied specialties dealing with these cases of NF 1.
Kikuchi-Fujimoto Disease
Authors: Sawant Sangeeta Priyadarshi , Amin Alpa S. , Gaddam Prachi R. , Chaturvedi Uma P.
Published: November 2023

Background:

Kikuchi Fujimoto disease (KFD) is a rare, benign self-limited disease characterized by prolonged regional lymphadenopathy associated with or without systemic signs or symptoms. It is a rare diagnosis in children. Due to the lack of pathognomonic clinical symptoms/signs, KFD poses a significant challenge to the clinician. Its diagnosis is confirmed by lymph node biopsy.

Clinical Description:

A 12.5-year boy presented with chronic cervical lymphadenopathy of 6-week duration, associated with mild-moderate fever, pain, and weight loss. He had raised erythrocyte sedimentation rate, leukopenia, lymphopenia, and thrombocytopenia. Mantoux test was positive. He was managed as a case of tuberculous lymphadenopathy till the lymph node biopsy confirmed the diagnosis of KFD.

Management:

The child recovered without medications. There has been no recurrence or relapse in 1.5 years of follow-up.

Conclusion:

This case report highlights the importance of considering the diagnosis of KFD in children presenting with persistent or chronic lymphadenopathy.
Necrotizing Enterocolitis as a Possible Manifestaion of Multisystem Inflammatory Syndrome in Neonates Related to SARS-CoV-2
Authors: Kumar Chanchal , Pothala Rajeev , Bathina Sushma Poornima , Dodda Deepika
Published: November 2023

Background:

Multisystem inflammatory syndrome in neonates (MIS-N) is hypothesized to be caused either following transplacental transfer of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies or antibodies developed in the neonate after infection with SARS-CoV-2. The common clinical manifestations include fever, respiratory distress, shock, and encephalopathy. Gastrointestinal manifestations include vomiting, diarrhea, bloody stools, and gastric residues. Necrotizing enterocolitis (NEC) has not been described before in MIS-N.

Clinical Description:

We report a term neonate presenting on day 10 of life with 2 days history of fever, abdominal distension, vomiting, reduced feeding, and not passing stool. He had tachycardia, tachypnea, a distended tense and tender abdomen with absent bowel sounds, and excessive irritability. Salient investigation results were anemia, neutrophilic leukocytosis, hyponatremia, metabolic acidosis, and elevated inflammatory markers. Dilated bowel loops on abdominal radiograph and thickening of bowel wall on abdominal ultrasonography were consistent with NEC. In view of the unusual presentation of NEC, the elevated biomarkers and setting of the pandemic, MIS-N was suspected, investigated, and the diagnostic criteria were found to be satisfied.

Management:

The baby received supportive care. Methylprednisolone, intravenous immunoglobulin, aspirin, and enoxaparin were started resulting in defervescence and decline in inflammatory markers. However, he developed fixed bowel loops and underwent an exploratory laparotomy. This revealed stricture and extensive necrosis of the terminal ileum with adhesive obstruction. The affected segment was excised, and loop ileo-colostomy was done. He gradually improved and was discharged on the 11th postoperative day on enteral feeds. The infant was thriving on follow-up.

Conclusion:

NEC may be a possible manifestation of MIS-N.
Unclassified Sudden Infant Death Due to Congenital Long QT Syndrome with TRPM4 Mutation
Authors: Kaur Jasleen , Puri Ratna Dua , Mukherjee Sharmila B. , Vyas Bijal
Published: November 2023

Background:

Congenital long QT syndrome (cLQTS) are heritable disorders due to genetic mutations causing prolonged corrected QT (QTc) interval that may result in fatal arrhythmias.

Clinical Description:

A well 20-day-old, exclusively breastfed boy had an episode of unresponsiveness with no other symptoms. There was a history of four previous unexplained infantile deaths after similar complaints. General and systemic examination was normal. The differential diagnoses were neonatal apnea, seizures, and inborn errors of metabolism.

Management:

Sepsis, hypoglycemia, and electrolyte imbalance were ruled out. Electrocardiography (ECG), chest radiograph, and echocardiograph were normal. Ultrasonogram of the cranium ruled out structural abnormality and bleed. Electroencephalogram was normal. First-line metabolic investigations were normal. On day 28 of life, he had a recurrent episode of apnea. ECG evaluation during this episode revealed a prolonged QTc interval. Suspecting cLQTS, Trio Whole Exome Sequencing for mutations in the cLQTS susceptibility genes was performed in the proband and parents. A heterozygous variation, c.290C>T; p. Thr97Met in TRPM4 was identified in the symptomatic neonate and asymptomatic mother, suggesting autosomal dominant inheritance. The baby was started on oral propranolol, but succumbed at 8 weeks. The mother was referred for cardiac management and parents counseled about possible prenatal diagnosis in subsequent pregnancies.

Conclusion:

cLQTS should be suspected in neonatal apnea, when no other cause is appreciable. A normal ECG does not exclude cLQTS. If there is a strong suspicion, repeat ECGs and appropriate genetic testing should be done. Patients should be managed according to standard guidelines.
Giant Juvenile Fibroadenoma in a Young Female-A Diagnostic Dilemma
Authors: Gautam Vasu , Khanna Chetna , Meena Atul Kumar , Debnath Pinaki Ranjan
Published: November 2023

Background:

Fibroadenoma is the most common breast lesion among pediatric female population. A giant fibroadenoma is rare, characterized by a rapidly growing tumor, with a mass >5 cm diameter in greatest dimension and/or weighing more than 500 gm. Phyllodes tumor range from benign to malignant. Both have similar presentation.

Clinical Description:

An 11-year-old girl presented with rapidly progressive, painless increase in the size of the left breast over 2 months. Local examination revealed a firm nontender mass involving the upper inner and outer quadrants of the left breast along with the retro-areolar region. The mass was mobile and measured approximately 11 cm × 10 cm. The overlying skin was normal, although with dilated veins and free from underlying mass. The clinical phenotype was suggestive a phyllodes tumor in view of rapid progression and large size. However, the ultrasonogram and fine-needle aspiration cytology favored a fibroadenoma.

Management:

It was decided to perform a “Nipple-areolar complex sparing lumpectomy” with deferment of reconstructive surgery. Adequate lump excision was achieved while maintaining proper cosmesis. The histopathological findings of the excision biopsy confirmed the final diagnosis of fibroadenoma.

Conclusion:

A large breast mass in a pediatric/adolescent girl poses a diagnostic dilemma to the treating surgeon. Proper evaluation is needed to differentiate between several benign breast masses from malignant ones. The definitive diagnosis is made histologically. Total excision of the lump with conservation of nipple and areola is indicated to make a definitive diagnosis and to relieve the compression of the normal breast tissue.
Matched Unrelated Hematopoietic Stem Cell Transplant in Juvenile-Onset Krabbe's Disease
Authors: Misra Ruchira , Bhat Sunil , Shah Suhani , Hegde Anaita , Panwala Hiren , Hingwala Divyata
Published: November 2023

Background:

Krabbe's disease is a neurodegenerative condition caused by a deficiency of a lysosomal enzyme, galactocerebrosidase (GALC), found mainly in the brain. There are four variants based on the age of onset: Infantile, late infantile, juvenile, and adult. Hematopoietic stem cell transplants can be curative as the GALC-positive donor cells migrate to the brain and provide GALC, thus correcting the deficiency. However, this is most effective when performed in the asymptomatic or mildly symptomatic phase. Maximum experience is in infantile-onset disease. The types of transplants usually used are matched sibling donor transplant or umbilical cord blood transplant.

Clinical Description:

A 5-year-old girl, the only child of a nonconsanguineous marriage, presented with complaints of frequent falls and progressive visual deterioration for 2 months. After evaluation, the clinical phenotype was ascertained to be that of a juvenile-onset (>5 years) neurodegenerative disorder with neuro-axis involvement of the brain (predominantly, white motor involvement-because of gait abnormalities and visual involvement) and absence of organomegaly or any other systemic involvement. Krabbe's disease was suspected. Supportive evidence was found on neuroimaging and confirmed by a homozygous mutation in the GALC gene that was consistent with Krabbe's disease.

Management:

The patient was treated with a matched unrelated bone marrow transplant, a modality that is generally not used in the management of Krabbe's disease. The clinical, neurophysiological, and neuroradiological profiles are compared during a 2-year follow-up. Currently, 2 years' posttransplant, she has not deteriorated further neurologically, and though legally blind is attending a special school for the visually impaired and performing most activities of daily living independently.

Conclusion:

Early matched unrelated donor transplant can be beneficial in juvenile-onset Krabbe's disease.
Spectrum of Lesions in Acrokeratosis Verruciformis of Hopf
Authors: Khan Farhat , Pathave Hari , Nayak Chitra
Published: November 2023

ABSTRACT

Acrokeratosis verruciformis of Hopf (AVH) is a rare genodermatosis with an autosomal dominant mode of inheritance. It is a disorder of keratinization characterized by multiple flat-topped skin-colored or fleshy, dull-red to brown keratotic lesions resembling plane warts mainly observed on the dorsum of the hands and feet. Herein, we present a case of AVH who presented with hypopigmented and hyperpigmented macules with papular lesions and was diagnosed on histopathology.
Crazy Paving Pattern Due to Invasive Pulmonary Aspergillosis: A Rare Case Report with Literature Review
Authors: Rai Deependra K. , Kumar Prashant
Published: November 2023

ABSTRACT

The “crazy-paving” pattern at thin-section computed tomography of the lungs is characterized by ground-glass attenuation with superimposed interlobular septal thickening and intralobular lines, have various infective and non-infective causes described in literature but rarely described with aspergillus infection. We herein presented a very rare case of a crazy-paving pattern as a radiological manifestation of acute invasive pulmonary aspergillosis.
Cardiac Distress in an Infant – Giant Right Atrial Myxoma Obstructing Right Ventricular Inflow and causing Cardiac Arrest
Authors: Pawar Ranjit D. , Garg Anurag , Dolas Ashish
Published: November 2023

ABSTRACT

Cardiac myxomas are extremely rare in infants, but many times are life endangering. We report a case of giant right atrial myxoma in a 7-month-old child obstructing tricuspid valve inflow, causing severe metabolic acidosis and near cardiac arrest. The child was treated with emergency surgical excision of intracardiac myxoma saving her life.
Adjuvant Dexmedetomidine in Treatment of Alcohol Withdrawal Delirium: Case Series
Authors: Chail Amit , Ray Madhubrata , Singh Ranveer , Dhiman Mayank
Published: November 2023

ABSTRACT

Alcohol withdrawal delirium is a medical emergency with mortality rates of 20–50% without treatment. Benzodiazepines (BZDs) (gamma-aminobutyric acid receptor agonists) are the mainstay of treatment. Alcohol withdrawal delirium is associated with sympathetic hyper-activity and marked agitation, which in severe cases respond poorly to BZDs alone. Very high doses of BZDs pose risk of respiratory depression and further complications such as aspiration pneumonia which can worsen the treatment outcome. Dexmedetomidine is a selective Alpha-2 adrenergic agonist which has been approved by US Food and Drug Administration for short-term sedation of intubated and mechanically ventilated adult patients in intensive care unit settings and for sedation of non-intubated patients during invasive procedures. Its unique sedative, sympatholytic, and respiratory sparing properties can supplement and can reduce the dose requirement of BZDs while managing such cases. We present three cases of severe alcohol withdrawal delirium [delirium tremens (DT)] who responded poorly to initial BZD treatment but responded well to adjunctive dexmedetomidine infusion. Dexmedetomidine is a pragmatic adjunct to BZDs in severe delirium tremens.
Intraoperative Diagnosis of Neoplastic Lesions by Imprint Cytology and Frozen Section with Histopathological Correlation
Authors: Deoghare Saroj , Ali Syed S. , Dhawan Shrutika , Sawaimul Komal D.
Published: November 2023

ABSTRACT

Introduction:

Intraoperative consultation examinations are required by surgeons from pathologists for immediate important decisions regarding the optimal extent of surgery. Surgeons particularly want to know whether a lesion is malignant or not. Both frozen section (FS) and touch impression cytology serve this purpose well. Both provide accurate results in minutes while the patient is under anesthesia. The surgeon then modifies his surgical plan based on the intraoperative consultation from pathologist.

Objectives:

The objective of this study is to access the role of imprint cytology (IC) and FS in diagnosis of tumors of different organs, to correlate IC and FS findings with histopathological diagnosis and to determine their diagnostic accuracy.

Materials and Method:

This present prospective cross-sectional study was done in the pathology department of BKL Walawalkar Rural Medical College, Dervan, Chiplun, for a period of one and a half year. A total of 161 surgical specimens from various organs were studied using IC and FS. The results of both the techniques were compared with the gold standard histopathological diagnosis.

Results:

Statistical correlation of IC and FS with histopathology shows that true positive cases on IC are 88.7% and on FS are 85.1%. Sensitivity, specificity, and diagnostic accuracy of IC and FS are 95.7%, 81.8%, 94.7% and 93.2%, 78.9%, 92%, respectively. Combined diagnostic accuracy is 93.5%.

Conclusion:

IC and FSs are interdependable intraoperative diagnostic modalities. IC is a simple, accurate, rapid, and cost-effective diagnostic tool, intraoperatively. FS preserves crisp cellular and nuclear detail and also closely approximates permanent histopathology sections. Thus, a combination of IC and FS helps in achieving high diagnostic accuracy rates and in distinguishing benign and malignant lesions.
Revolutionizing Non–Small Cell Lung Cancer Diagnosis: Ultra-High-Sensitive ctDNA Analysis for Detecting Hotspot Mutations with Long-term Stored Plasma
Authors: Lee Ji-Young , Jeon Seyeon , Jun Ha Ra , Sung Chang Ohk , Jang Se Jin , Choi Chang-Min , Chun Sung-Min
Published: November 2023

Purpose Circulating cell-free DNA (cfDNA) has great potential in clinical oncology. The prognostic and predictive values of cfDNA in non–small cell lung cancer (NSCLC) have been reported, with epidermal growth factor receptor (EGFR), KRAS, and BRAF mutations in tumor-derived cfDNAs acting as biomarkers during the early stages of tumor progression and recurrence. However, extremely low tumor-derived DNA rates hinder cfDNA application. We developed an ultra-high-sensitivity lung version 1 (ULV1) panel targeting BRAF, KRAS, and EGFR hotspot mutations using small amounts of cfDNA, allowing for semi-quantitative analysis with excellent limit-of-detection (0.05%).Materials and Methods Mutation analysis was performed on cfDNAs extracted from the plasma of 104 patients with NSCLC by using the ULV1 panel and targeted next-generation sequencing (CT-ULTRA), followed by comparison analysis of mutation patterns previously screened using matched tumor tissue DNA.Results The ULV1 panel demonstrated robust selective amplification of mutant alleles, enabling the detection of mutations with a high degree of analytical sensitivity (limit-of-detection, 0.025%-0.1%) and specificity (87.9%-100%). Applying ULV1 to NSCLC cfDNA revealed 51.1% (23/45) samples with EGFR mutations, increasing with tumor stage: 8.33% (stage I) to 78.26% (stage IV). Semi-quantitative analysis proved effective for low-mutation-fraction clinical samples. Comparative analysis with PANAMutyper EGFR exhibited substantial concordance (κ=0.84).Conclusion Good detection sensitivity (~80%) was observed despite the limited volume (1 mL) and long-term storage (12-50 months) of plasma used and is expected to increase with high cfDNA inputs. Thus, the ULV1 panel is a fast and cost-effective method for early diagnosis, treatment selection, and clinical follow-up of patients with NSCLC.
Temporal Trend in Uptake of the National General Health Checkups and Cancer Screening Program among Korean Women with Breast Cancer
Authors: Tran Thi Xuan Mai , Kim Soyeoun , Cha Chihwan , Park Boyoung
Published: November 2023

Purpose This study assessed the temporal trends of uptake of national general health and cancer screening among women with breast cancer in Korea between 2009 and 2016.Materials and Methods We retrospectively analyzed the claims data from the Korean National Health Insurance Service database. Participants included 101,403 breast cancer patients diagnosed between 2009 and 2016. Information on participation in national screening programs, including breast cancer screening, general health, and gastric, colorectal, and cervical cancers, up to 2020 was collected. Screening participation rates within the first 2 and 5 years postdiagnosis were calculated by diagnosis year and fitted with joinpoint regression models to assess temporal trends.Results Overall, the participation rate in breast cancer screening within 2 years postdiagnosis increased from 10.9% to 14.0% from 2009-2016, with an annual percentage change (APC) of 3.7% (p < 0.05). The participation rate in breast cancer screening was lower than that in general health checkup and screening for other cancers within 2 and 5 years postdiagnosis. A steady increase in screening trends was also observed for general health, gastric, colorectal, and cervical cancers, with APC of 5.3%, 5.7%, 6.9%, and 7.6% in the 2-year postdiagnosis rate, and APC of 3.6%, 3.7%, 3.7%, and 4.4% in 5-year postdiagnosis rate, respectively. The screening rate was highest among age groups 50-59 and 60-69 in 2009 and significant upward trends were observed in all age groups for general health checkup and gastric, colorectal, and cervical cancer screening.Conclusion Among female breast cancer survivors in Korea, the uptake rate of screenings for general health and various cancers, including breast, gastric, colorectal, and cervical cancers, has shown a gradual increase in recent years.
Bredon homology of partition complexes
Authors: Arone G. Z. , Dwyer W. G. , Lesh K.
Published: November 2023

We prove that the Bredon homology or cohomology of the partition complex with fairly general coefficients is either trivial or computable in terms of constructions with the Steinberg module. The argument involves a theory of Bredon homology and cohomology approximation.
Rational torsion on the generalized Jacobian of a modular curve with cuspidal modulus
Authors: Yamazaki Takao , Yang Yifan
Published: November 2023

We consider the generalized Jacobian

\widetilde{J}_{0}(N)

of a modular curve

X_{0}(N)

with respect to a reduced divisor given by the sum of all cusps on it. When

N

is a power of a prime

\geq 5

, we exhibit that the group of rational torsion points

\widetilde{J}_{0}(N)(\mathbb {Q})_{\text{Tor}}

tends to be much smaller than the classical Jacobian.
Møller operators and Hadamard states for Dirac fields with MIT boundary conditions
Authors: Drago Nicoló , Ginoux Nicolas , Murro Simone
Published: November 2023

The aim of this paper is to prove the existence of Hadamard states for Dirac fields coupled with MIT boundary conditions on any globally hyperbolic manifold with timelike boundary once a suitable propagation of singularities theorem is assumed. To this avail, we consider particular pairs of weakly-hyperbolic symmetric systems coupled with admissible boundary conditions. We then prove the existence of an isomorphism between the solution spaces to the Cauchy problems associated with these operators – this isomorphism is in fact unitary between the spaces of

L^2

-initial data. In particular, we show that for Dirac fields with MIT boundary conditions, this isomorphism can be lifted to a

*

-isomorphism between the algebras of Dirac fields and that any Hadamard state can be pulled back along this

*

-isomorphism preserving the singular structure of its two-point distribution.
Free noncommutative hereditary kernels: Jordan decomposition, Arveson extension, kernel domination
Authors: Ball Joseph A. , Marx Gregory , Vinnikov Victor
Published: November 2023

We discuss (i) a quantized version of the Jordan decomposition theorem for a complex Borel measure on a compact Hausdorff space, namely, the more general problem of decomposing a general noncommutative kernel (a quantization of the standard notion of kernel function) as a linear combination of completely positive noncommutative kernels (a quantization of the standard notion of positive definite kernel). Other special cases of (i) include: the problem of decomposing a general operator-valued kernel function as a linear combination of positive kernels (not always possible), of decomposing a general bounded linear Hilbert-space operator as a linear combination of positive linear operators (always possible), of decomposing a completely bounded linear map from a

C^*

-algebra

\mathcal{A}

to an injective

C^*

-algebra

\mathcal{L}(\mathcal{Y})

as a linear combination of completely positive maps from

\mathcal{A}

to

\mathcal{L}(\mathcal{Y})

(always possible). We also discuss (ii) a noncommutative kernel generalization of the Arveson extension theorem (any completely positive map

\phi

from an operator system

\mathbb{S}

to an injective

C^*

-algebra

\mathcal{L}(\mathcal{Y})

can be extended to a completely positive map

\phi_e

from a

C^*

-algebra containing

\mathbb{S}

to

\mathcal{L}(\mathcal{Y}))

, and (iii) a noncommutative kernel version of a Positivstellensatz (i.e., finding a certificate to explain why one kernel is positive at points where another given kernel is strictly positive).
The pro-étale topos as a category of pyknotic presheaves
Authors: Wolf Sebastian
Published: November 2023

In this paper we will show that for a quasicompact quasiseparated scheme

X

the hypercomplete pro-étale

\infty

-topos, as introduced by Bhatt and Scholze, is equivalent to the

\infty

-category of continuous representations of the Galois category

\mathrm{Gal}(X)

of

X

with values in the

\infty

-category of pyknotic spaces. In particular this proves that internally to pyknotic spaces, the hypercomplete pro-étale

\infty

-topos of

X

is an

\infty

-category of presheaves.
The homotopy type of the topological cobordism category
Authors: Gomez Lopez Mauricio , Kupers Alexander
Published: November 2023

We define a cobordism category of topological manifolds and prove that if

d\neq 4

its classifying space is weakly equivalent to

\Omega^{\infty -1}MT\mathrm{Top}(d)

, where

MT\mathrm{Top}(d)

is the Thom spectrum of the inverse of the canonical bundle over

B\mathrm{Top}(d)

. We also give versions for manifolds with tangential structures and/or boundary. The proof uses smoothing theory and excision in the tangential structure to reduce the statement to the computation of the homotopy type of smooth cobordism categories due to Galatius–Madsen–Tillman–Weiss.
Singularities in the weak turbulence regime for the quintic Schrödinger equation
Authors: de Suzzoni Anne-Sophie
Published: November 2023

In this paper, we discuss the problem of derivation of kinetic equations from the theory of weak turbulence for the quintic Schrödinger equation. We study the quintic Schrödinger equation on

L\mathbb{T}

, with

L\gg 1

and with a non-linearity of size

\varepsilon\ll 1

. We consider the correlations

f(T)

of the Fourier coefficients of the solution at times

t=T\varepsilon^{-2}

when

\varepsilon\rightarrow 0

and

L\rightarrow\infty

. Our results can be summed up in the following way: there exists a regime for

\varepsilon

and

L

such that for

T

dyadic,

f(T)

has the form expected from the Physics literature for kinetic regimes, but such that

f

has an infinite number of discontinuity points. This discontinuity appears in the context of finite-box effects.
On superspecial abelian surfaces over finite fields
Authors: Xue Jiangwei , Yang Tse-Chung , Yu Chia-Fu
Published: November 2023

In this paper we establish a new lattice description for superspecial abelian varieties over a finite field

\mathbb F_q

of

q=p^{a}

elements. Our description depends on the parity of the exponent

a

of

q

. When

q

is an odd power of the prime

p

, we give an explicit formula for the number of superspecial abelian surfaces over

\mathbb F_q

.
Diplomatic Ukrainian-Belarusian relations in the context of a full-scale war
Authors: Lisiecka Maria Zofia
Published: November 2023

The relevance of this study and the stated problem primary lies in the fact that Ukraine has a large common border with Belarus, which is why the political and security situation within it directly affects the national security of Ukraine. It is also worth noting that this topic is not sufficiently disclosed in the works of other domestic and foreign scientists, political scientists and historians. In this regard, the purpose of this scientific work is to study the diplomatic relations between Ukraine and the Republic of Belarus, as well as the prospects for their development in the context of a full-scale war between Russia and Ukraine. In addition, the tasks of the work are to study the influence of Belarus on the Russian-Ukrainian war. The following scientific methods are the main ones in this research: analysis, induction, synthesis, comparison and graphical methods of presenting information. In the article, the concept of diplomacy is revealed, the procedure for establishing diplomatic relations between states is described. It is considered how Belarus and Ukraine implemented their foreign policy towards each other after the collapse of the Russian Empire and the declaration of independence of the young states. It has been studied the conclusion of diplomatic relations between the Republic of Belarus and Ukraine in 1991 and the course of bilateral relations between the states until 2022. It has also been considered how Belarus contributed to Russia's military aggression against Ukraine, as well as its role in this conflict. Special attention is paid to the course of the Russian-Ukrainian peace negotiations that has taken place on the territory of Belarus in 2022. The materials of the article are of practical and theoretical value for political scientists, historians and other representatives of the scientific community who are interested in the diplomatic relations between Ukraine and Belarus
Factors of the impact of Britainʼs withdrawal from the European Union on Ukraine and Europe. Ukrainian-British relations in the late 20th and early 21st centuries
Authors: Kravtsov Yury
Published: November 2023

The functioning of the union of countries with various political, economic, social, and cultural orientations is an important question, which lies in the feasibility of such a union. The United Kingdom is one of the countries that had a peculiar national development strategy that became inconsistent with the pan-European direction. Resolving the problems that have arisen within the framework of cooperation between the UK and the European Union is important to ensure the continued future existence of the EU and to maintain stability in Europe as a whole. The disadvantages and problems that resulted from Brexit could have a major impact on the EU, as the UK was one of the largest and most influential members of the EU. The purpose of this study was to examine the consequences of Britainʼs withdrawal from the EU for Ukraine and Europe as a whole. It is also possible to explore potential opportunities for further development of relations between Ukraine and the UK, given the new conditions after the UKʼs exit from the EU. The study used such scientific methods as chronological, comparative, and historical, systematisation, analysis and synthesis, generalisation, and graphical. The main results of the study of the topic are to determine the history of Britainʼs existence in the European Union, to substantiate the specific features of political behaviour in the Union, to identify the reasons and factors that influenced the countryʼs withdrawal from the European Union. One of the tasks was to investigate the direction of the UKʼs international strategy towards Ukraine. The study analysed the development of Ukrainian-British relations in the late 20th and early 21st centuries. The paper described the consequences of Britainʼs withdrawal for Europe and Ukraine. The study showed the directions of Britainʼs foreign policy towards Ukraine in 1992-2016. The problems and prospects of Ukrainian-British relations after Britainʼs withdrawal from the European Union were considered. This study can help communications professionals understand how to communicate Brexit to the general public in Ukraine and Europe. The study can also help in understanding how to interact with British colleagues working in the field of international relations and trade
Problems of researching the history of exile of Ukrainians and of the Baltic peoples in the USSR
Authors: Konieczny Marcin
Published: November 2023

This study investigated the conditions of exile and interaction between Ukrainian and Baltic prisoners in Soviet camps in the post-war period. The scientific relevance of the subject lies in the investigation of the cooperation of political prisoners of diverse national groups, which led to the camp uprisings of 1953-1954. The purpose of this study was to determine the nature of the conditions of exile and the opportunities for contacts between Ukrainian and Baltic prisoners in the context of protest formation using evidence from the camp departments of Vorkuta, specifically Rechlag. To fulfil this purpose, the methods of comparative and retrospective analysis, historical and psychological reconstruction were used. The study identified common and distinctive features inherent in the Vorkuta camps. It was found that the basis for interaction between Ukrainian and Baltic prisoners was their common situation and attempts to improve living conditions in the camp. Therewith, it was stated that the same cultural and educational level and participation in the anti-Soviet resistance improved the establishment of interethnic contacts. The socio-psychological characteristics of Ukrainian and Baltic prisoners of the postwar era distinguished them from others. It was found that the unification into national groups was facilitated by the self-identification of prisoners as captives with a national worldview and experience that opposed Soviet ideology. The main goal was to improve the conditions and release prisoners from places of captivity, and active attempts to achieve this came after Stalin’s death. It was proved that political uncertainty and chaotic actions of the camp administration became a catalyst for uprisings that accelerated the transformation of places of captivity. A key role in organising the protests belonged to strike committees representing groups of prisoners on ethnic grounds. Specifically, Ukrainian, and Baltic prisoners took an active part in them. This shows the place and role of these nations in the camp uprisings. The practical significance of this study lies in highlighting the little-studied issue of the ways in which Ukrainian and Baltic political prisoners interacted and the impact of these contacts on the fight against the Soviet repressive apparatus in prison
Finitude and woman
Authors: Pelaez Sol
Published: November 2023

This article explores the connection among woman, sex, and finitude. In stuying finitude, the argument follows the articulation of finitude with woman. In a first part, it discusses three “women” writers—Virginia Woolf, Simone De Beauvoir, and Hélène Cixous—to establish their thoughts on woman in terms of finitude. The three of them are identified as women and yet they problematized what to be a woman is. In tracing their thoughts on finitude and woman, sexual difference –the body as enjoying emerges as an issue. Thus, in a second part, it discusses two seemingly opposed positions—Lacanian psychoanalysis, with Joan Copjec, and deconstruction, with Derrida—to think further about the question of woman, sexual difference, the “two,” and finitude. This study compares the Lacanian feminine side with the movement of deconstruction and establishes the necessity of thinking a “two” beyond the binary of phallogocentrism. My thesis is that thinking finitude with woman leads us to a non-oppositional two that correlates with sexual difference. The Lacanian feminine side, and Derrida’s deconstruction aim to think these two logics, delineating two sides: a male one (comparable with phallogocentrism) and a feminine side (comparable with the movement of deconstruction). If the male side considers finitude (death) as the limit of life, the feminine side opens to death and life, and the in-finitude of the undetermined and undecidable. In thinking finitude with woman, the knowledge of what to be a woman is, becomes undetermined and undecidable.
OSNOVNI PRAVNI PROBLEMI I MOGUĆA REŠENjA U VEZI REGULISANjA POLOŽAJA PRIVATNIH VOJNIH KOMPANIJA NA MEĐUNARODNOM PLANU
Authors:   University of Kragujevac, Faculty of Law, Palević Milan
Published: November 2023

The existence and operation of private providers of military security services initiates a multitude of legal, political, moral and even practical issues. The paper presents and analyzes some of the key legal issues that arise before the doctrine and the official public in the process of regulating this relatively new area of international life. In addition to presentation and explanation, the paper refers to the possibility of applying existing legal concepts to the set problem.
The Influence of Halal Awareness, Religiusity, Brand Image , and Price on Decisions to Purchase Halal Cosmetic Products With Preference as an Intervening Variable
Authors: Farajun Rikza Ilmi , Munir Misbahul , Wadud Nafis Abdul
Published: November 2023

Understanding the concept of halal tayyiban is a predictor of consumer attitudes towards halal cosmetics so that this attitude can influence the intention to purchase halal cosmetics. In addition, it is important for producers to include halal certification/logos because both Muslim and non-Muslim consumers perceive halal-certified products as tastier, more hygienic and safer. So this shows that the more confident consumers are about the halalness of the product, the greater the consumer's liking (preference) for the product. The research stages in this journal began by distributing questionnaires directly to halal cosmetics consumers at Roxy Square Jember. The number of indicators in this research was 24 so that a sample of 120 respondents was obtained. The sampling method used in this research is non-probability sampling. Sampling used an incidental sampling approach. Data obtained from the results of distributing questionnaires will be processed and presented in quantitative form. The steps taken to convert questionnaire data into quantitative data are by giving a value to each item answered by the respondent.
Evolución de los modelos de negocios, un análisis en el contexto de la economía circular
Authors: Sornoza José Manuel Morales , Muñoz Landy Lilibeth Mora , Garrido Karol del Cisne Moscoso , Merelo Gabriela Emilia Cedeño , Almeida Adriana Gissela Molina , Aguirre Jorge Marco Litardo
Published: November 2023

Los modelos de negocios convencionales han sido la norma durante gran parte del siglo XX y se caracterizan por un enfoque lineal en la producción y el consumo. Estos modelos se han centrado principalmente en la eficiencia y la maximización de las ganancias, con menos consideración por las implicaciones sociales y ambientales de sus operaciones. En este artículo, se exploran los componentes clave de estos modelos y cómo han influido en la economía global, luego se investigan nuevos modelos de negocio en desarrollo, con enfoques circulares y se valoran las ventajas en términos económicos, ambientales y sociales que pueden derivar de este cambio. Al hacerlo, se busca destacar un tema crucial en el contexto empresarial actual y aportar al entendimiento de cómo las organizaciones pueden progresar hacia una economía que sea tanto más sostenible como circular. Como metodología de investigación se utilizó un enfoque cualitativo que involucró la recopilación y análisis de datos para una comprensión profunda de estos aspectos, se llevó a cabo una revisión exhaustiva de la literatura y fuentes secundarias.
Optimization of Ultrasound-Assisted Protein Extraction from Watermelon Seeds: Taguchi Approach
Authors: GÜLDANE Mehmet
Published: November 2023

Nowadays, there has been a growing interest in finding alternative protein sources for both the food industry and nutritional purposes. Protein experts have recently focused on investigating watermelon seeds, which are not only a food processing waste but also contain high-quality proteins. Therefore, this study aimed to achieve maximum protein extraction from watermelon seeds using an ultrasound-assisted extraction process. The study investigated the effects of pH (A; 7─11), sonication temperature (B; 30─60 °C), and sonication time (C; 5─15 min) on protein recovery to develop a Taguchi model. Through optimization, the optimal conditions for maximum protein recovery (85.81%) within the range of process variables were found to be 11 pH, 45 °C sonication temperature, and 10 min sonication time (A3B2C2). An analysis of variance (ANOVA) revealed that pH and sonication temperature significantly influenced the protein extraction process (P
Penerapan Metode Demonstrasi Guna Meningkatkan Hasil Belajar Siswa Kelas XI IPA pada Pembelajaran Pendidikan Agama Islam di SMA Muhammadiyah 2 Wuluhan
Authors: Styawan Yusril , Rofi Sofyan , Huda Hairul
Published: November 2023

This research aims to determine the improvement in students' learning outcomes through the application of the demonstration method in the subject of Islamic Religious Education, specifically the topic of Funeral Prayer (Shalat Jenazah), in class XI Science at Muhammadiyah 2 Wuluhan High School. The research method used in this study is Classroom Action Research (CAR). The research was conducted from May 10, 2023, to May 25, 2023, in class XI Science at Muhammadiyah 2 Wuluhan High School. Data collection method was a test, and the instrument used was a student test sheet. Based on the research results obtained, student engagement increased during the implementation of the demonstration method. Specifically, the percentage of learning achievement in Cycle I was 77%, and in Cycle II, it increased to 85%. The conclusion drawn from this research is that teaching the demonstration method for the Funeral Prayer material showed that the application of the demonstration learning method led to an increase in students' learning outcomes, with a percentage increase in the pre-cycle, Cycle I, and Cycle II in each meeting, successfully meeting the completion criteria.
The Land for the Community: Protection of Community Land Rights in Land Procurement for National Strategic Projects
Authors:   Faculty of Law, Diponegoro University, Indonesia, Wibawa Kadek Cahya Susila , Mahfud Muh. Afif ,   Faculty of Law, Diponegoro University, Indonesia
Published: November 2023

The government formed a policy that negated land rights for the community in Rempang. Also, They chose to side with foreign investment in national strategic projects which ultimately generated agrarian conflict. This research aims to analyze the minimal protection of community land rights in national strategic projects and the construction of community land rights protection in national strategic projects. The problem was studied through doctrinal research using statutes and a conceptual approach and analyzed using content analysis techniques. Based on the analysis, it is concluded that the government policy that negated the rights of the people on Rempang Island was not in line with the aim of the right to control the state, namely to maximize the prosperity of the people and customary law as the basis of national agrarian law which emphasizes protecting the rights of people who have lived for generations. To overcome this problem, government policy construction should emphasize the value of justice which pays attention to the weak and the social and cultural conditions of society. In making and implementing policies, public participation must also be taken into account.
Bardet-Biedl Syndrome: A Comprehensive Review of an Autosomal Recessive Ciliopathy
Authors:   Universidad Autónoma De Guadalajara, Guadalajara, Jalisco. México., Martin Francisco Vázquez , Valdez Jimenez Hector Manuel ,   Universidad Autónoma De Guadalajara, Guadalajara, Jalisco. México., l Umaña Reye Mauricio Emmanue ,   Instituto de Ciencias y Estudios Superiores de Tamaulipas, Tampico, Tamaulipas. México, Valadez García Valeria Macías ,   Universidad Autónoma de Aguascalientes, Aguascalientes. México., Vargas Rivera Ingrid Debhany ,   Instituto de Ciencias y Estudios Superiores de Tamaulipas, Tampico, Tamaulipas. México, Roselli Gutiérrez Elsa María ,   Universidad Autónoma De Guadalajara, Guadalajara, Jalisco. México.
Published: November 2023

Bardet-Biedl Syndrome (BBS) is a rare, genetically heterogeneous, and autosomal recessive ciliopathy characterized by a complex clinical phenotype. This article provides a comprehensive review of BBS, exploring its genetic underpinnings, clinical manifestations, molecular mechanisms, and emerging therapeutic strategies. BBS is associated with primary ciliary dysfunction, leading to a spectrum of clinical features, including obesity, retinal degeneration, renal abnormalities, polydactyly, and cognitive impairments. Understanding the intricate molecular pathways involved in BBS pathogenesis, such as the role of the BBSome and the ciliary transition zone, is crucial for developing targeted treatments. This review also discusses recent advances in the field, including the potential application of gene therapy and small molecule interventions. The aim of this article is to consolidate current knowledge on BBS, shedding light on the complexities of this rare genetic disorder and the potential avenues for future research and therapeutic development.
Unraveling the Mysteries of Cystic Fibrosis: Causes, Symptoms, and Treatment Strategies
Authors:   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., Gámez Acosta María Fernanda , Minguela Ingrid Pamela Rodríguez ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., López Álvarez Ivan Fernando ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., Zermeño Medina Alejandra ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., Martínez Jorge Baltazar Márquez ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., González Ana Luisa Brito ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., Oliva Arvizu Alejandro Herbert ,   Universidad de Guadalajara. Guadalajara, Jalisco, México.
Published: November 2023

In this work we present the most relevant and important data, so that the reader will be able to identify the disease "Cystic Fibrosis", regardless of the fact that in Mexico this disease is not common, thanks to the fact that in Mexico and in the world newborns are screened. In this way the rate of this disease in Mexico and the world was reduced. In Mexico, there are 350 new cases every year, said the General Director of the National Center for Gender Equity and Reproductive Health, Dr. Ricardo García Cavazos. Thanks to this data, the purpose of this work is to guide readers in the identification of this disease and in this way generate a positive and active influence in the identification of this disease. This disease is a disease that has its historical antecedents since the year 1595, when with the thought of a spell on a girl during her autopsy, the first clinical data that are characteristic of this disease were given. Being in the 70's where with the passage of time and as new knowledge came to what we know today. Cystic fibrosis is an inherited multisystem disorder of children and adults, it is the leading cause of severe chronic lung disease in children. Cystic fibrosis occurs most often in white populations in Northern Europe, North America and Australia/New Zealand and is inherited in an autosomal recessive manner.
Financial Literacy, Risk Perceptions, and Consumptive Behavior on Interest in Using Online Loans
Authors:   Faculty of Economics and Business, Dr. Soetomo University Surabaya, Indonesia, Kirana Khiba Fahlevy , Ady Sri Utami ,   Faculty of Economics and Business, Dr. Soetomo University Surabaya, Indonesia
Published: November 2023

This study aims to determine the influence of financial literacy, risk perception, and consumptive behavior on interest in using online loans in college students of the Faculty of Economics and Business, Dr. Soetomo University, Surabaya. This research is quantitative. The data sources used are primary and secondary data. Data collection techniques by distributing questionnaires and collecting literature as research reference material. Sampling using purposive sampling method and obtained samples of 50 college students. The data analysis method used in this study is a classical assumption test and multiple linear regression analysis using IBM SPSS Statistic data processing program version 25. The results showed that financial literacy negatively affects interest in using online loans, risk perception negatively affects interest in using online loans, consumptive behavior positively affects interest in using online loans, and financial literacy, risk perception, and wasteful behavior simultaneously affect interest in using online loans.