bluuebunny/crossref_metadata_2025 huggingface dataset:
AN OBSERVATIONAL STUDY OF CLINICAL AND HEMATOLOGICAL PROFILE OF CIRRHOSIS OF LIVER
Authors: BEHERA BIBHU PRASAD , Dash Manoranjan
Published: May 2020

Objective: Efforts can be made to normalize the hematological parameters so that the morbidity and mortality in these patients could be effectively reduced.

Methods: This observational study was carried out among 69 cirrhosis patients that fulfills the inclusion and exclusion criteria, attended the medicine outpatient department, and admitted in medicine ward of PRM Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India, from June 2018 to January 2019.

Results: In our study, we had 59 male and 10 female patients with an average age of 49.8±13.19 years. About 92.75% of the patients were alcoholic. Abdominal distension (92.75%) and ascites (84.06%) were the most common presenting complaints. Pallor was present in 42 (60.87%) cases. Splenomegaly was present in 35 (50.72%) cirrhotic patients. Renal dysfunction was present in 23 (33.33%) cases. Sixty-six (95.65%) patients had anemia and 47 (68.12%) patients had thrombocytopenia.

Conclusions: From this study, we can conclude that, in cirrhosis of liver patients, various hematological changes are very common which need to be identified and corrected early to reduce morbidity and mortality.
REVERSAL OF CISPLATIN-INDUCED MEMORY IMPAIRMENT BY GALLIC ACID IN EXPERIMENTAL RAT MODEL
Authors: Patel Sucharita , HM Chandan , KL Krishna , HS Nandini , Ghosh Abhinav Raj , AN Bhooshitha
Published: May 2020

Objective: The objective of the study was to evaluate the protective effect of gallic acid on cisplatin-induced memory impairment (MI) in the rat model.

Methods: Five groups of Wistar albino rats (n=6) were employed and the duration of the study was 22 days, excluding the pre-treatment period. Animals were pretreated with gallic acid for a period of 5 days and continued daily (200 mg/kg) for 22 days. The cisplatin (3 mg/kg) was given once in a week for 3 consecutive weeks to induce MI, whereas donepezil was used as standard. The evaluation was done by a change in body weight, memory activity by Morris water maze (MWM), locomotor activity by actophotometer, antioxidant activity by thiobarbituric acid reactive substance (TBARS), glutathione (GSH), and estimation of acetylcholinesterase (AChE) activity in brain homogenate.

Results: Administration of cisplatin has induced MI by increasing in escape latency time, decrease in time spent in the target quadrant in the MWM task and it was reversed by gallic acid treatment. Decreased locomotor activity by cisplatin was also increased by gallic acid when tested by actophotometer. Cisplatin administration has induced oxidative stress by increasing TBARS and decreasing GSH levels. Gallic acid due to its proven antioxidant activity reversed the effects of cisplatin. The AChE level was significantly increased in the control group, whereas treatment groups have shown a decrease in AChE level.

Conclusion: Gallic acid may serve as a primary agent to treat the cognitive impairment and oxidative stress associated memory dysfunctions. However, more extensive studies are needed before utilization in the clinical trial.
A REVIEW NOVEL CORONAVIRUS
Authors: PARAMESHWAR KONDAPURAM , PAMU SAGAR , SANDEEP KOSIKA , SURESH CHINDAM
Published: May 2020

Coronaviruses (CoVs), incorporated positive-sense RNA diseases, are depicted by the club-like spikes that adventure from their surface, an abnormally huge RNA genome, and a specific replication technique. CoVs cause a selection of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory sickness in chickens too possibly deadly human respiratory diseases. Here, we provide a quick presentation to CoVs talking about their replication and pathogenicity, and current avoidance and treatment techniques. We likewise mention the episodes of the profoundly pathogenic severe acute respiratory syndrome CoV (SARS-CoV) and thus the recently identify Middle Eastern respiratory syndrome CoV (MERS-CoV).
OPTIMIZATION OF DRUG SOLUBILITY USING ASPEN PLUS: ACETYLSALICYLIC ACID (ASPIRIN) SOLUBILITY – A SECOND CASE STUDY
Authors: AL-MALAH KAMAL I
Published: May 2020

Objective: The objective of the study is to optimize the solubility of a drug or a drug-like molecule using Aspen Plus simulation platform. Aspirin (solute) was taken as the second case study. The following solvents were used in our dry (virtual) laboratory experiment: Water, acetone, ethanol, and ethylene-glycol-mono-propyl-ether (PROPGLYC).

Methods: A simplified process flow sheet made of a single mixing tank where it has five feed streams, representing the solute, the water, and the set of three organic solvents, and one product stream where aspirin is either solubilized (liquid solution) or remains as solid crystal. Minimization of the molar Gibbs free energy of mixing, ΔGmix, was used as an objective function from an optimization point of view. The Non-random Two-liquid property method was used to analyze the solution properties.

Results: Using the molar Gibbs free energy of mixing, ΔGmix, as a criterion of solution thermodynamic stability, it was found that the most stable solution is the quinary mixture made of 24.42% aspirin, 10.22% water, 21.08% acetone, 19.51% ethanol, and 24.77 mole % PROPGLYC.

Conclusions: Exploiting Aspen Plus can be extended to handle the solubility of a new drug-like molecule once it is defined within its molecular editor with a little knowledge such as density and/or melting point.
VIRTUAL SCREENING OF STILBENE ANALOGUE AND INSILICO, IN VITRO ANTIPROTOZOAL EVALUATION OF LEAD MOLECULES
Authors: Lalasa G. , Vijayaraj S. , Thamizhvanan K. , Chaithanyaveena K.
Published: May 2020

Objective: The objective of present study is the virtual screening of stilbene analogues followed by the in silico and in vitro evaluation for its anti protozoal activity.Methods: The method of virtual screening selected is the structure-based virtual screening using ChEMBL database. The in silico analysis was performed using auto dock tools 4.2. The docking was performed using 1T5F (Arginase I-OH complex) as the binding proteins which are drawn from the protein data bank.Results: The stilbene analogues from virtual screening are allowed to dock with the proteins the binding energies and docking positions were determined using auto dock tools 4.2. The in vitro evaluation of anti protozoal activity was performed.Conclusion: The stilbene analogues are capable of producing the antiprotozoal activity.
PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY EFFECT OF THE AQUEOUS EXTRACT OF TABERNAEMONTANA DIVARICATA FLOWER IN WISTER RATS
Authors: Garga Deepankar , Das Trishna
Published: May 2020

Objective: To determine the phytochemical analysis and anti-inflammatory effect of the aqueous extract of Tabernaemontanadivaricata flower in Wister Rats.Methods: The aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae) were prepared and analyzed for phytochemical constituents using standard methods. The anti-inflammatory activity of the plant extracts was examined with the help of rat models by taking diclofenac as a standard drug against T. divericata oil extract by using carrageenan induced rat paw edema method with the help of the instrument plethesmometer.Results: The present experiment shows the phytochemical analysis, anti-inflammatory activity of the aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae). Various phytochemical analysis revealed the presence of saponins, flavonoids, glycosides, steroids, proteins, phenols, amino acids and tannins. The oil extract of the plant showed much effective anti-inflammatory activity against the standard drug.Conclusion: It can be concluded aqueous extract of the flower of the plant Tabernaemontanadivaricata (family-Apocyanaceae) contain the high presence of phytochemicals. This extract was found to possess promising antimicrobial activity when compared with the standards.
FORMULATION DEVELOPMENT AND EVALUATION OF NASAL IN-SITU GEL OF FLUTICASONE PROPIONATE
Authors: Saudagar R. B. , Khandbahale Sarika V.
Published: May 2020

Objective: Over a few decades, advances in the in-situ gel technologies have spurred development in may medical and biomedical applications including controlled drug delivery. For locally acting intra nasal drugs, an extended residence time in the nasal cavity is desirable and related to a prolonged effect. The aim of the present work was to design a nasal delivery system with improved mucoadhesive properties that could provide prolonged retention time for the treatment of the allergic rhinitis.Methods: A 32 factorial design was used to investigate the effect of the amount of Poloxamer 188 and carbopol 934 as independent variables. % drug release and mucoadhesive strength were taken as dependent variables. The formulations were tested for gelation study, viscosity study, gel strength, mucoadhesion study, drug content and stability study. Gelation was determined by physical appearance, viscosity study of solution and gel formulations indicated that increase in polymer concentration increase the viscosity.Results: Gel strength was found in the range of 0.55-2.36 sec. The mucoadhesive force in terms of detachment stress increase with an increase in the concentration of carbopol 934. A stability study for optimized formulation as per ICH guideline for 90 d showed no change in pH, drug content and viscosity.Conclusion: The developed in-situ gelling system for Fluticasone Propionate using poloxamer188 in combination with carbopol 934 with improved mucoadhesive properties that could provide prolonged retention time for the treatment of allergic rhinitis.
PRELIMINARY PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND MUSCLE RELAXANT ACTIVITY OF THE ETHANOLIC EXTRACT OF THE LEAVES OF MIRABILIS JALAPA
Authors: Bharali Deepsikha , Saha Dipankar
Published: May 2020

Objective: The aim and objectives of the present work is to determine pharmacological activity upon ethnopharmacological survey. The present study deals with phytochemical screening and analgesic as well as muscle relaxant activity of leaves of Mirabilis jalapa.Methods: The present study is aimed at phytochemical screening and evaluating the analgesic and muscle relaxant activities of ethanolic leaf extract of Mirabilis jalapa by using hot plate method and rota rod method respectively [1, 2]. The Phytochemical screening of the extract was done according to the standard procedures to reveal the presence of the active constituents like Alkaloids, flavonoids, phenols, glycosides, tannins, saponins, steroids, carbohydrates etc [3-5].Results: The analgesic and muscle relaxant activity study were dose dependent. The EEMJ extracts (100 mg/kg, 200 mg/kg, 500 mg/kg) and the standard drug Diclofenac sodium (25 mg/kg) shows significant increase in the reaction time when compared with control at 30 min, 60 min, 90 min and 120 min and the effect of standard was found to be highest during the study. Another study was designed to evaluate the skeletal muscle relaxant properties of ethanolic extract of leaves of Mirabilis jalapa. Linn by taking the EEMJ extracts (100 mg/kg, 200 mg/kg, 500 mg/kg) and standard drug Lorzepam (10 mg/kg). Both the extracts and standard drug show decrease in the fall of time in a dose dependent manner when compared with control at 15 min, 30 min, 45 min respectively. Conclusion: Therefore, from the above study it is revealed that Mirabilis jalapa showing better pharmacological activities (Analgesic and Muscle relaxant) in dose dependent manner.
ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF THE LEAF EXTRACTS OF EUCALYPTUS GLOBULUS
Authors: Abirami Subramanian , Nishanthini Kannan , Poonkothai Mani
Published: May 2020

Objective: To investigate the antimicrobial activity and phytochemical analysis of Eucalyptus globulus leaves.Methods: The antimicrobial activity of the leaves of E. globulus extracted with acetone, ethanol and petroleum ether was studied using well diffusion method against the selected bacterial and fungal isolates. The antimicrobial susceptibility of the bacteria and fungi to various concentrations of the extract was evaluated by the micro broth dilution method. The preliminary phytochemical screening was performed in the acetone extract of E. globulus. The presence of functional groups in the acetone extract of the leaves of E. globulus was determined by Fourier to transform infrared (FT-IR) spectroscopy.Results: Results suggested that the acetone extract exhibited maximum antimicrobial activity against the tested bacteria and fungi when compared with ciprofloxacin and fluconazole respectively (standard antibiotics). Minimum inhibitory concentration (MIC) showed that the wells containing a concentration of 12.5 mg/ml and 6.25 mg/ml of acetone extract inhibited the bacteria and fungi effectively. Phytochemical screening of acetone extract of E. globulus showed the presence of alkaloids, flavonoids, phenols, tannins, quinones, glycosides, steroids, terpenoids and leucoanthocyanides. FT-IR spectral analysis of the leaf extract of E. globulus showed the presence of functional groups such asâ€“OH,-NH, C=O andâ€“COOH.Conclusion: Thus to conclude, different plants and their formulations have been used in ayurveda to cure diseases for several decades. The findings of the study indicate the potential to exploit the leaves of Eucalyptus globulus in the treatment of microbial diseases.
EFFECTIVE MANAGEMENT OF ODONTOGENIC INFECTIONS THROUGH CONTROLLED FASHION BY POLYMERIC DEVICE CONTAINING MOXYFLOXACIN
Authors: P. Gorle A. , V. Mahale H. , S. Patil C.
Published: May 2020

Objective: Present work demonstrates the use of film that releases the drug at a pre-programmed manner. Several methods have been explored for management of moxifloxacin in dealing of Odontogenic infections which are mainly caused by necrotic pulp or by bacterial invasion from the periodontal tissue. These are usually mixed bacterial infections, and they penetrate mostly into the soft and bony oromaxillofacial tissues to produce submucosal infiltrates and abscesses.Methods: The films were developed with the intention to minimize the dose of a drug, to deliver definite concentration and to preserve dosage at its site for a longer period by this means gets a better patient compliance. Moxifloxacin films were prepared by solvent casting technique using gellan gumÂ at different concentrations and PEG 400 as plasticizers. Compatibility study such as FT-IR and DSC also performed to check the interaction between drug and excipients used. The formulations were evaluated for their thickness, weight uniformity, folding endurance, content uniformity, surface pH, In vitro drug release. Optimized formulations were subjected to in vitro antibacterial activity and stability studies to assess the effectiveness of the formulations.Results: Formulations shown the good uniformity of drug content, there was no any kind of effect on moisture loss test. Weight and thickness of the films were found to be uniform. Plasticizer like PEG400 was found to influence their effect on drug release as well as characteristics of films.Conclusion: In vitro studies revealed that the formulations provide the best alternative to prolong drug release at the end of 10 h and formulations remained stable with intact at ambient conditions.Â
QUANTIFICATION OF PHYTOCHEMICAL CONSTITUENTS AND IN VITRO ANTIOXIDANT ACTIVITY IN THE LEAVES OFCITRUS MEDICA
Authors: Patil Mayavatis
Published: May 2020

Objective: In the present investigation, phytochemical assay and in vitro antioxidant activity of ethanol (70%), methanol, ethyl acetate and hexane extract of Citrus medica leaves were carried out.Methods: The quantification of total phenolic and alkaloid contents were estimated by taking gallic acid and atropine as standard. Inâ€“vitro antioxidant activity of extracts was evaluated by using different free radicals (DPPH, superoxide and free radicals).Results: Ethanol extract of leaves have more phenolic and alkaloid contents than other extracts. The selected plant extract was produced concentration dependent percentage inhibition of different free radicals and produced maximum activity at a concentration of 1000Âµgm/ml, and there after percentage inhibition was raised gradually to its maximum level with higher concentrations. HPLC analysis revealed the presence of Gallic acid, Catechein, Rutin, Chlorgenic acid, Queracetine and some unknown components which need to be e identified.Conclusion: Among the four extracts, ethanol extract of C. medica showed good antioxidant activity.Â
PHARMACOLOGICAL EVALUATION OF ANTIANXIETY ACTIVITY OF DESMOSTACHYA BIPINNATA LEAVES IN ANIMAL MODELS
Authors: I. Veena Rani , G. Kiranmai , Pulla Ravi Pratap
Published: May 2020

Objective: Anxiety is a widespread psychiatric disorder affecting around 5% of the population. Furthermore, it is difficult to predict patientâ€™s response to any given treatment. In the traditional systems of medicine, many plants have been used to treat anxiety and depression for thousands of years. Desmostachyabipinnata belongs to the family Poaceae, have pharmacological actions like dysenteryÂ andÂ menorrhagia, and as aÂ diuretic. The present study was designed to evaluate the antianxiety activity of the alcoholic and aqueous extracts of Desmostachyabipinnata leaves in rodents.Methods: Antianxiety activity was screened by different methods like elevated plus maze model and actophotometer.Results: The results infer that reduced aversion fear elicits anti-anxiety activity.Conclusion: It was concluded that alcoholic and aqueous extracts of Desmostachyabipinnata leaves are having anti-anxiety activity among which alcoholic extract of Desmostachyabipinnata leaves showing more significant activity over the aqueous extract.Â
EVALUATION OF ETHANOLIC ROOT EXTRACT OF PARTHENIUM HYSTEROPHORUS LINN FOR ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY
Authors: Lohumi Pankaj , Kumar Tirath , Nogai Lipi
Published: May 2020

Objective: The work is aimed to draw out the health beneficial properties of a weed (Parthenium hysterophorus Linn). The present work is organized to evaluate the antioxidant and anti-inflammatory activity of the ethanolic root extract of Parthenium hysterophorus Linn.Methods: In the present work the ethanolic extract was determined by using soxhlet apparatus. The antioxidant scavenging activity of this extract was determined by applying three different assay methods: (1) DPPH (1, 1-diphenyl-2-picryl hydrazyl) free radical method. (2) Nitric oxide scavenging assay and (3) Reducing power method. The anti-inflammatory activity was determined by in vivo method i.e. Carrageenan induced rat paw edema.Results: DPPH radical scavenging activities of the standard antioxidant and extracts were found to be increased in dose dependent manner. The percentage inhibition increases from 4.19% to 97.09% within the concentration range of 10Âµg/ml to 160Âµg/ml. Parthenium hysterophorus Linn effectively reduced the generation of nitric oxide radicals from sodium nitroprusside solution in a concentration dependent manner and percentage inhibition increases from 3.53% to 55.21% within the concentration range 10Âµg/ml to 160Âµg/ml. All the concentrations of extract significantly showed higher absorbance than the absorbance of control reaction (0.9705) in reducing power assay. A Higher absorbance indicates high reducing power due to the formation of reduced intermediates. Parthenium hysterophorus Linn showed highly significant anti-inflammatory activity at a dose of 200 mg/kg and the lesser effect was observed at 100 mg/kg with the percentage change in paw volume at 0 min, 30 min, 60 min, 90 min and 120 min.Conclusion: Thus, from above experimental observations, it can be stated that Parthenium is a natural antioxidant and bearing anti-inflammatory activity.Â
MICROSCOPIC, PHYSICOCHEMICAL AND PHYTOCHEMICAL SCREENING OF CRATEVA MAGNA (LOUR) DC. (LEAF)
Authors: J. Abirami , G. Jothi , P. Brindha
Published: May 2020

Objective: Preliminary screening of phytochemicals is a valuable step, in the detection of the bioactive principles present in medicinal plants and subsequently may lead to drug discovery and development. In the present study, the identity, purity and strength of Crateva magna (Lour) DC. (Leaf), HPTLC, LC MS and phytochemical screening were analysed.Methods: Tests for Identity, Purity, and Strength of Crateva magna (Lour) DC. (Leaf) Botanical standards, Physicochemical constants such as Foreign matter, Total ash, moisture content, Acid insoluble ash, and water soluble ash and Extractive value such as Hexane, Chloroform, Ethyl acetate, Alcohol were determined. The Preliminary Phytochemical Analysis of various extracts was also determined. HPTLC, LCMS ANALYSIS was analysed.Results: Microscopic studies T S of Crateva magna leaf shows the presence of prominent midrib, upper and lower epidermis and lamina. Preliminary phytochemical analysis of dry powder and aqueous extracts of Crateva magna (Lour) DC. (Leaf) showed the presence of flavones, steroids, glycosides, sugar, alkaloids, quinones, phenols, coumarin and lignin. HPTLC of an Aqueous extract of the Crateva magna (Lour) DC. (Leaf). LC MS spectrum indicates may be the presence of bioactive compounds.Conclusion: The results revealed that aqueous extract of Crateva magna (Lour) DC. (Leaf) has suitable for anti ulcer study.
Peranan Bendesa dalam Penyelesaian Sengketa Tanah Waris di Desa Adat Buduk
Authors: Widyantara I Gede Suka , Sukadana I Ketut , Sudibya Diah Gayatri
Published: May 2020

Abstract-In the inheritance system, people in Bali have a system of inheritance that originates from the male kinship system which causes the relationship to be emphasized more according to the husband's lineage. Generally, any inheritance disputes do not have to end in court, because disputes about inheritance involve adat law in their resolution. Moreover, if the inheritance land dispute is still a family dispute, then the settlement should also be settled amicably through the active role of the Bendesa as the Leader in Pakraman Village. The formulation of the problem in this study is: How is the regulation of inheritance in Pakraman Buduk Village ?, What is the role of Bendesa in the settlement of inheritance land disputes in Pakraman Buduk Village? The problems discussed are examined from an empirical point of view. The results showed that the inheritance arrangement in Pakraman Buduk Village was in accordance with the contents of awig-awig Pakraman Buduk village contained in Palette 4 Pawos 75 to Pawos 78 which included inheritance, heirs, heir obligations, inheritance distribution, and loss of rights to be heir. The role of adat Bendesa in the settlement of inheritance land disputes in Desa Pakraman Buduk as a mediator.

Keywords: Inheritance, Bendesa, Dispute Resolution

Abstrak-Dalam sistem kewarisan, masyarakat di Bali memiliki sistem kewarisan yang bersumber dari sistem kekerabatan laki-laki yang menyebabkan pertalian hubungan lebih dititikberatkan menurut garis keturunan suami. Umumnya pada setiap sengketa tanah waris tidak harus berakhir di pengadilan, karena sengketa tentang waris melibatkan hukum adat dalam penyelesaiannya. Apalagi kalau sengketa tanah waris tersebut masih merupakan sengketa yang bersifat kekeluargaan, maka penyelesaiannya pun seharusnya diselesaikan secara kekeluargaan melalui peranan aktif dari pihak Bendesa selaku Pemimpin di Desa Pakraman. Rumusan masalah dalam penelitian ini adalah Bagaimana pengaturan warisan di Desa Pakraman Buduk ?, Bagaimana peranan Bendesa dalam penyelesaian sengketa tanah waris di Desa Pakraman Buduk ?. Permasalahan yang dibahas dikaji berdasarkan sudut pandang empiris. Hasil penelitian menunjukkan, bahwa Pengaturan warisan di Desa Pakraman Buduk sesuai dengan isi awig-awig Desa Pakraman Buduk termuat dalam Palet 4 Pawos 75 sampai dengan Pawos 78 yang mencakup tentang harta warisan, ahli waris, kewajiban ahli waris, pembagian warisan, dan kehilangan hak untuk menjadi ahli waris. Peranan Bendesa adat dalam penyelesaian sengketa tanah waris di Desa Pakraman Buduk sebagai mediator.

Kata Kunci: Warisan, Bendesa, Penyelesaian sengketa
Ekstradisi Sebagai Upaya Pencegahan Dan Pemberantasan Kejahatan Internasiona
Authors: Dewi Dwi Melia Nirmalananda , Sepud I Made , Sutama I Nyoman
Published: May 2020

Abstract-The presence of a person to a country to escape resulted in the creation of many criminal crimes on an international scale, this requires special treatment, such as the existence of an international agreement, one of which is Extradition. Then it must be reviewed in advance regarding regulation and then move on to understanding the practice of extradition in preventing and combating international crime. The problems in this study are first, how is the regulation of extradition in preventing and combating international crime, second, how is the practice of extradition between countries in preventing and combating international crime. The research method used is a type of Normative research by using a statutory approach, conceptual approach and case approach which are analyzed using systematic techniques by being presented descriptively-analytically assisted with primary, secondary and tertiary legal sources which are collected and then interpreted. Focused on understanding and fulfilling the principles and procedures for compliance with international laws and conventions governing extradition and also focusing on cooperation between interested countries, in collaboration with ICPO-INTERPOL and NCB-INTERPOL who are competent in carrying out extradition.

Keywords: Between Countries, Extradition, International Crime.

Abstrak-Kehadiran seseorang ke suatu negara untuk melarikan diri mengakibatkan terciptanya banyak kejahatan-kejahatan pidana dengan skala internasional, ini membutuhkan penanganan khusus, seperti adanya perjanjian internasional salah satunya Ekstradisi. Maka wajiblah dikaji terlebih dahulu mengenai pengaturan lalu beranjak ke pemahaman praktek ekstradisi dalam mencegah dan memberantas kejahatan internasional. Adapun permasalah yang didapat dalam penelitian ini pertama, bagaimanakah pengaturan ekstradisi dalam mencegah dan memberantas kejahatan internasional, kedua, bagaimanakah praktek ekstradisi antar negara dalam mencegah dan memberantas kejahatan internasional. Metode penelitian yang digunakan merupakan tipe penelitian Normatif dengan melakukan pendekatan perundang-undangan, pendekatan konseptual dan pendekatan kasus yang dianalisis menggunakan teknik bersifat sistematis dengan disajikan secara deskriptif-analitis dibantu dengan sumber bahan hukum primer, sekunder dan tersier yang dikumpulkan lalu ditafsirkan. Difokuskan kepada pemahaman dan pemenuhan prinsip-prinsip serta tatacara pelaksanaan sesuai Undang-Undang dan konvensi Internasioal yang mengatur tentang Ekstradisi dan difokuskan pula kepada kerjasama antar negara yang berkepentingan, bekerjasama dengan ICPO-INTERPOL dan NCB-INTERPOL yang berkompeten dalam melaksanakan ekstradisi.

Kata Kunci: Antar Negara, Ekstradisi, Kejahatan Internasional.
FATORES DE RISCO E IDEAÇÃO SUICIDA EM PESSOAS COM TENTATIVA DE SUICÍDIO, FORTALEZA, CEARÁ, BRASIL
Authors: Oliveira Maria Ivoneide Veríssimo , Bezerra Filho José Gomes , Feitosa Regina Fátima Gonçalves , Sousa José Edir Paixão
Published: May 2020

Considerado um problema de saúde pública pela crescente prevalência, o suicídio é uma das maiores causas de mortalidade no mundo, especialmente entre jovens. Anualmente, um milhão de pessoas cometem suicídio. No Brasil, a análise do perfil epidemiológico do suicídio tem demonstrado crescimento nas últimas décadas. Entre os estados brasileiros com as maiores taxas estão Rio Grande do Sul, Santa Catarina, Paraná, São Paulo e Goiás. Fortaleza é a sétima capital em suicídios. Este artigo visa descrever os fatores de risco associados à ideação suicida entre pessoas com história de tentativas de suicídio atendidas em unidades públicas de saúde de Fortaleza, Ceará, Brasil. Trabalhou-se com amostra por conveniência com 360 vítimas, nos centros de atenção psicossocial geral, álcool/drogas e infantil; adolescente, Instituto Doutor José Frota e Projeto Apoio à Vida da Universidade Federal do Ceará. A abordagem foi quantitativa com utilização de um questionário com perguntas estruturadas e escala de ideação suicida de Beck. Na análise estatística, usou-se como desfecho presença de ideação suicida, associado às variáveis independentes. Na análise multivariada mantiveram significância estatística: sentir-se rejeitado, RC = 1,99 (IC95%:1,21-2,57), p = 0,006; não seguir recomendações religiosas, RC = 1,82 (IC95%:1,10-3,0), p = 0,019; fazer tratamento para o problema de saúde, RC = 2,43 (IC95%:1,41-4,19), p = 0,001; e presença de depressão, RC = 1,096 (IC95%:1,07-1,12), p = 0,001. Necessariamente, novos estudos devem melhor explorar os resultados ora relatados e assim contribuir com ações e planejamento para a saúde mental de Fortaleza.

Palavras-chave: Fatores de risco. Ideação suicida. Tentativa de suicídio. Depressão. Saúde mental.
AS PRÁTICAS INTEGRATIVAS E COMPLEMENTARES EM SAÚDE E SUA RELAÇÃO COM AS EPISTEMOLOGIAS DO SUL
Authors: Silva Cleyton Cézar Souto , Medeiros Soraya Maria de
Published: May 2020

Este trabalho é um ensaio crítico ancorado nas epistemologias do Sul e nas possibilidades que as práticas integrativas e complementares trazem quando ocorrem como política pública a fim de discutir a importância da (co)existência de saberes, conhecimento e práticas na saúde. Partimos da compreensão de que tais práticas são potentes por possibilitarem tanto o encontro real como simbólico dos saberes e das diferenças. As epistemologias do Sul tornam-se uma alternativa reflexiva para o cuidado em saúde pois são uma forma de constatar as dominações e limitações do paradigma dominante da ciência moderna e de suas relações desiguais de saber e poder. Desta forma, a prática e o cuidado em enfermagem podem se reinventar visando à superação dos paradigmas, efetivando uma postura mais abrangente em relação a saúde, doença e terapêutica que ultrapasse o modelo biomédico centrado no aspecto tecnomecanicista da ciência.

Palavras-chave: Terapias complementares. Saúde pública. Epistemologias do sul.
Ichthyofauna of Düzce Province (Turkey): Population and Habitat Evaluation
Authors: Güçlü Salim Serkan
Published: May 2020

This study aimed to analyze the distribution, endemism-conservation status, habitat features of inland water fish species and some threats in Düzce inland water systems. Fish samples were collected using electrofishing equipment, gill nets, fyke nets, and cast nets between April-October 2016. We have identified 17 fish taxa belonging to 9 families (Salmonidae (1 taxa), Acheilognothidae (1 taxa), Cyprinidae (2 taxa), Gobionidae (1 taxa), Leuciscidae (7 taxa), Tincidae (1 taxa), Cobitidae (1 taxa), Percidae (1 taxa), Gobiidae (2 taxa)). As a result of field observations conducted in Düzce province inland water, we determined 4 endemic (Gobio baliki, Squalius pursakensis, Alburnoides coskuncelebii and Cobitis splendens) and 2 invasive species (Carassius gibelio, Oncorhynchus mykiss). Endemic species were observed in narrow areas and small populations. Fish fauna and habitats were observed to be under the influence of drying, water and sand extraction, dam and pond building, pollution, mining and invasive species pressure.
A evolução do conceito de trabalho e sua relação com o desenvolvimento econômico
Authors: Queiroz Francisco Alves , Souza Laumar Neves de
Published: May 2020

O presente artigo tem como objetivo analisar historicamente as relações da categoria trabalho e desenvolvimento econômico, a evolução do conceito de trabalho, bem como a transição do trabalho escravo para o assalariado. Para tanto, realizou-se um estudo bibliográfico que descreve os aspectos conceituais do trabalho fundamentado no prisma marxista. A pesquisa parte da premissa de que a capacidade produtiva da sociedade está aliada ao uso do trabalho como mercadoria e que a classe burguesa produz riqueza via exploração do trabalhador. O investimento no trabalhador não acompanha o processo de incorporação de progresso tecnológico às máquinas e equipamentos, e isso promove um desequilíbrio estrutural na sociedade. O acúmulo de riqueza ocorreu, primeiramente, entre a nobreza e o clero, depois, na classe burguesa capitalista. A sociedade e o Estado devem se empenhar em produzir um mercado de trabalho menos fragmentado, com a ampliação das relações assalariadas, sujeitas à proteção social e à homogeneização das condições de trabalho. Segundo a pesquisa, um dos fatores principais para o efetivo desenvolvimento é a criação de emprego, com remuneração que permita a manutenção das condições essenciais à vida.
Características dos peritos contadores judiciais do estado de Pernambuco
Authors: Souza Vitória Regina Alves de , Santos Josaias Santana dos , Junior Florisvaldo Cunha Cavalcante
Published: May 2020

A perícia contábil é um ramo da contabilidade que visa elaborar uma prova pericial ou laudo pericial. Trata-se de uma forma de garantir a veracidade das informações apresentadas pelas partes envolvidas em um processo judicial. Assim, a problemática deste artigo é investigar quais as particularidades da profissão de peritos contadores e o objetivo geral é caracterizar o perfil dos peritos contadores nas esferas judiciais do estado de Pernambuco. Realizou-se a coleta de dados por meio de questionário misto aplicado entre os peritos constantes no Cadastro Nacional de Peritos Contadores (CNPC) até 31 de dezembro de 2017. Os questionários foram enviados por e-mail para todos os cadastrados e foram obtidas 25 respostas, o que representa 18,65% do universo. A análise dos dados classifica-se como quantitativa e o método utilizado foi o Survey.  Não obstante a área civil proporcionar uma remuneração maior, a atividade que apresentou maior demanda foi a área trabalhista. A obtenção de documentos necessários para a realização de perícia é a principal dificuldade citada pelos peritos. Constatou-se que as principais dificuldades dos peritos para se inserir no mercado de trabalho são: a obtenção de documentos necessários para a realização do processo, baixa remuneração, tempo para realização da perícia, nomeação por partes de juízes e apoio das partes envolvidas. De modo geral, os referidos profissionais estão satisfeitos com a profissão e participam de cursos de educação continuada duas vezes a cada seis meses.
Entre ausências e emergências, genocídios e epistemicídios: notas sobre metrópole e “espacialidades enegrecidas”
Authors: Azevedo Felipe Taumaturgo Rodrigues
Published: May 2020

Este trabalho é uma proposição alternativa às condições quase sempre imutáveis dos estudos que se debruçam sobre o urbano na Geografia. O interesse parte de um pressuposto que ratifique a necessária reconstrução e o enaltecimento da ciência geográfica enquanto materialidade indiscutivelmente potente, mas ainda indolente no que se refere a corpos de homens e mulheres negras que se especializam pela metrópole. Para além do apontamento de perspectivas problemáticas para o desenvolvimento da vida desses sujeitos, o artigo tenta valorizar o profícuo nascituro de postulados epistemológicos que podem surgir a partir disso. Por meio do diálogo com os debates relativos à analítica da colonialidade, sobretudo mediante sua relação com o corpo e o espaço, tentamos prostrar essa crítica.
RESEPSI KOMODIFIKASI HALAL PADA IKLAN JILBAB ZOYA
Authors: Lestari Juri , Adnani Kamila
Published: May 2020

Giving halal certification for many products is a guarantee that products is safe for consumption by a Muslim people. But media tend to using religion value to get a big commodity that profitable for company, or change the using value of religion to economic value. This research is a study about audience of television advertisement with the reception approach. This research is for knowing how are the Solo Hijabers community members meaning to Zoya Hijab advertisement. This research is using a qualitative method. Data analysis that using is Reception by Stuart Hall (encoding-decoding) with using three kind of analysis, dominant hegemonic position, negotiated position, and oppositional position. The result that researcher get is just showing two types, that is hegemonic dominant and negotiation. While the opposite position not happen to Hijabers Solo Community. In this research also found interesting something, although informant nothing have an attitude, meaning, and act the same way. They are still agree of hijab Zoya distribution in the market. Even they want to buy or using that hijab. Without they realize, they agree halal value to the Zoya hijab advertisement is a form of commodification.
MEDIA RELATIONS DINAS KOMUNIKASI DAN INFORMATIKA (DISKOMINFO) KABUPATEN KARANGANYAR DALAM SOSIALISASI PROGRAM PEMERINTAH
Authors: Rohmana Nur Laili Puspa , Pratiwi Rhesa Zuhriya Briyan
Published: May 2020

The importance of media relations conducted by a number of PRs in Government Agencies has implications for government policies in accordance with the information needs of the community. One of them is at the Office of Communication and Information (Diskominfo) Karanganyar Regency related to the issue of government program socialization. This study aims to describe the media relations strategy used by the Karanganyar Regency Office of Communication and Information in the socialization of government programs. The type of research used is descriptive qualitative. Data collection techniques using observation, interviews, and documentation. The results of the study, Diskominfo Karanganyar Regency uses media relations strategies by managing relations, developing strategies, and developing networks with the media to optimize each role of each section in Diskominfo for the benefit of the socialization of government programs for the community.
Determinants of Underpricing in Islamic and Non-Islamic Shares on IPO
Authors: Setya Vabila Ananta , Supriani Indri , Fianto Bayu Arie
Published: May 2020

This study aims at investigating the factors affecting the share’s underpricing in service companies of the Initial Public Offering (IPO) on the Indonesia Stock Exchange (IDX) covering the period from 2011 to 2017. Compared to the precedent studies, this study provides an empirical comparison between Islamic and non-Islamic shares on 22 underpricing stock samples from 44 IPOs in Islamic service shares and 21 underpricing samples from 32 IPOs in non-Islamic service shares. This study adopts a multiple linear regression analysis and an independent sample t-test method. It is revealed that the underwriter's reputation and auditor's reputation have a significant effect on the underpricing of IPO on IDX, both in Islamic and non-Islamic service companies. The result of independent samples t-test indicates that Islamic service shares companies have better financial performance compared to non-Islamic service shares companies. Predicated upon the results, this study implicatively insinuates that companies based on Shariah compliance could anticipate the underpricing level more expeditiously since the Shariah principles are in line with the decreasing level of underpricing.
Sharia Firm Value: The Role of Enterprise Risk Management Disclosure, Intellectual Capital Disclosure, and Intellectual Capital
Authors: Pratama Bima Cinintya , Sasongko Karin Maharani , Innayah Maulida Nurul
Published: May 2020

This present study aims to determine the effect of enterprise risk management disclosure, intellectual capital disclosure, and intellectual capital towards firm value. The population in this study is sharia commercial banks in Indonesia from 2010 through 2018. This research employs the purposive sampling technique to obtain a sample of 106 companies that met the criteria. Multiple regression analysis using the SPSS program was employed as the data analysis technique. The results of this study revealed that enterprise risk management disclosure has a positive effect on firm value. Moreover, the intellectual capital disclosure variable has negatively related to firm value. The intellectual capital variable, however, does not affect the firm value. The results of this study imply that sharia commercial banks are encouraged to optimize their risk management through the application of enterprise risk management. Moreover, the results further suggest that the sharia banks should also improve their intellectual capital performances to create a competitive advantage for the banks, and therefore it brings higher values for the banks.
Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells
Authors: Wang Kai , Dai Xiaozhen , He Junhong , Yan Xiaoqing , Yang Chengkui , Fan Xia , Sun Shiyue , Chen Jing , Xu Jianxiang , Deng Zhongbin , Fan Jiawei , Yuan Xiaohuan , Liu Hairong , Carlson Edward C. , Shen Feixia , Wintergerst Kupper A. , Conklin Daniel J. , Epstein Paul N. , Lu Chaosheng , Tan Yi
Published: May 2020

Diabetes-induced oxidative stress is one of the major contributors to dysfunction of endothelial progenitor cells (EPCs) and impaired endothelial regeneration. Thus, we tested whether increasing antioxidant protein metallothionein (MT) in EPCs promotes angiogenesis in a hind limb ischemia (HLI) model in endothelial MT transgenic (JTMT) mice with high-fat diet– and streptozocin-induced diabetes. Compared with littermate wild-type (WT) diabetic mice, JTMT diabetic mice had improved blood flow recovery and angiogenesis after HLI. Similarly, transplantation of JTMT bone marrow–derived mononuclear cells (BM-MNCs) stimulated greater blood flow recovery in db/db mice with HLI than did WT BM-MNCs. The improved recovery was associated with augmented EPC mobilization and angiogenic function. Further, cultured EPCs from patients with diabetes exhibited decreased MT expression, increased cell apoptosis, and impaired tube formation, while cultured JTMT EPCs had enhanced cell survival, migration, and tube formation in hypoxic/hyperglycemic conditions compared with WT EPCs. Mechanistically, MT overexpression enhanced hypoxia-inducible factor 1α (HIF-1α), stromal cell–derived factor (SDF-1), and vascular endothelial growth factor (VEGF) expression and reduced oxidative stress in ischemic tissues. MT’s pro-EPC effects were abrogated by siRNA knockdown of HIF-1α without affecting its antioxidant action. These results indicate that endothelial MT overexpression is sufficient to protect against diabetes-induced impairment of angiogenesis by promoting EPC function, most likely through upregulation of HIF-1α/SDF-1/VEGF signaling and reducing oxidative stress.
m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β Cells
Authors: Admin Ada , Wang Yanqiu , Sun Jiajun , Lin Zhen , Zhang Weizhen , Wang Shu , Wang Weiqing , Wang Qidi , Ning Guang
Published: May 2020

m6A RNA
modification is essential during embryonic development of various organs; however,
its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA
methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+
endocrine progenitors (Mettl3/14nKO)
developed hyperglycemia and hypo-insulinemia at 2 weeks after birth. We
found that Mettl3/14 specifically regulated both functional maturation and mass
expansion of neonatal β cells
before weaning. Transcriptome and m6A methylome analyses provided m6A-dependent
mechanisms in regulating cell identity, insulin
secretion and proliferation in neonatal β cells.
Importantly, we found that Mettl3/14 were dispensable for β cell differentiation,
but directly regulated essential transcriptional factor MafA expression at least partially via modulating its mRNA
stability and failure to maintain this modification impacted the ability to fulfill
β cell functional maturity. In both diabetic db/db mice and type 2 diabetes patients,
decreased Mettl3/14 expression in β cells were
observed, suggesting its possible role in type 2 diabetes. Our stud­­­­­­­­­y
unraveled the essential role of Mettl3/14 in neonatal β cell development and functional
maturation, both of which determined functional β cell mass and glycemic
control in adulthood.
Investigation on the melt ejection and burr formation during laser fusion cutting of stainless steel
Authors: Stoyanov S. , Petring D. , Arntz-Schroeder D. , Günder M. , Gillner A. , Poprawe R.
Published: May 2020

When the melt is ejected from the cut kerf by an assist gas during laser fusion cutting, a fraction of it may adhere to the lower cut edge and form a burr. Adjusting the process parameters to minimize burr formation is a challenging task that becomes more and more difficult as sheet thickness increases. The burr length has significant relevance when the quality of a cut is evaluated, but the underlying mechanisms that control its formation are still not fully understood. In this paper, new results of an experimental investigation focused on identifying characteristic melt ejection regimes are presented. The experiments were conducted on 6 mm thick stainless steel sheets using a disk laser at a power of up to 10 kW. The melt flow exiting the kerf channel and the temporal formation of burr were analyzed using two high-speed cameras. The dependency of melt ejection regimes from process parameters as well as their influence on burr formation is discussed. Furthermore, the authors demonstrate that melt ejection forming a compact and stable threefold outflow is a characteristic property of a burrfree cut.
Identifikasi Rumah Indekos Berbasis Syariah di Jalan Menco VII (Penekanan pada Pola Tata Ruang)
Authors: Romdloni Erlina , Priyatmono Alpha Febela
Published: May 2020

Dewasa ini rumah indekos telah berubah fungsi utamanya sebagai tempat tinggal menjadi sebuah industri indekos yang lebih berorientasi pada materi saja sehingga transformasi akan nilai-nilai yang ada dalam masyarakat cenderung terabaikan. Hal ini berakibat tidak menutup kemungkinan munculnya suatu perilaku menyimpang atau pelanggaran yang dilakukan oleh penghuni indekos, misalnya terjadi pergaulan bebas di lingkungan indekos. Universitas Muhammadiyah Surakarta yang merupakan kampus berbasis Islami memiliki tanggung jawab atas permasalahan yang ada di lingkungan sekitarnya, termasuk perilaku penyimpangan yang terjadi di kalangan civitas akademi. Tanggungjawab ini guna menghormati adab bermasyarakat dan menghasilkan generasi penerus bangsa yang baik. Permasalahan ini perlu diangkat untuk dicari penyebabnya, terutama sebab dari segi arsitektural, meliputi pola tata ruang yang berpengaruh pada kegiatan penghuni indekos dan Zonasi ruang indekos. Penelitian ini bertujuanuntuk mengetahui indekos dengan konsep pola tata ruang syariah yang mengedepankan nilai-nilai Islam sehingga permasalahan yang terjadi bisa diminimalisir. Obyek penelitian dilakukan di Jalan Menco Raya dimana terdapat berbagai jenis rumah indekos untuk mahasiswa. Sampel diambil secara acak di Jalan Menco VII yang terdapat lima indekos khusus puteri. Metode penelitian menggunakan diskriptif kualitatif melalui teknik observasi dan wawancara. Hasil penelitian menemukan bahwa keberadaan zona public berupa ruang tamu, dapat meminimalisir terjadinya pergaulan bebas, karena tamu tidak dapat masuk ke kamar indekos (putri). Disamping penyelesaian arsitektural, keberadaan penjaga indekos sebagai elemen non-arsitektural penting juga untuk menjamin keamaan penghuni indekos.