bluuebunny/crossref_metadata_2025 huggingface dataset:
Los mapas atestiguan… Impacto de las leyes de tierras coloniales en Argelia: 1830–1950
Authors: Benmati Hamani Ménouba
Published: July 2023

Durante tres siglos, los otomanos no importaron de forma masiva población turca ni “turquificaron” la tierra de la Regencia de Argel. Se contentaban con ocupar las mejores tierras agrícolas alrededor de las ciudades y recaudar impuestos de las tribus aliadas o vasallas. Las represiones y las guerras intertribales marcaron sin duda los tres siglos de presencia otomana, pero se estableció un cierto equilibrio dinámico en este territorio fundamentalmente pastoril y agrícola. A partir de 1830, los diferentes tipos de colonización se sucedieron, se entrelazaron, se solaparon y se opusieron, pero todos se apoyaron en un arsenal jurídico abusivo, un arma letal bien pensada e ineludible que se adaptaba a las necesidades del momento. Así se sucedieron leyes, decretos, órdenes, ordenanzas… para organizar la colonización agraria. Dos textos legislativos fundamentales tuvieron un impacto profundo y duradero en el territorio argelino: el Sénatus-Consulte de 1863 y la Ley Warnier de 1873. Estas dos leyes aparentemente opuestas fueron los instrumentos más eficaces en el proceso de desintegración de las comunidades rurales. ¿Cuál fue el impacto del Sénatus-Consulte en el territorio? ¿Cuál fue el impacto de las leyes que organizaron la colonización oficial? ¿Qué territorios fueron ampliamente ocupados? ¿Y los abandonados por el hecho colonial? ¿Qué territorios se vieron afectados por esta nueva política?
Proposta de marcação dupla em dicionários escolares
Authors: Bertonha Fábio Henrique de Carvalho
Published: July 2023

Ao estudarmos o léxico de um sistema linguístico, podemos ter uma compreensão sobre a realidade sócio-histórico-político-cultural de um povo, a qual é evidenciada pelo emprego das marcas de uso (HAUSMANN, 1977 apud WELKER, 2004) nos dicionários. À vista disso, a presente pesquisa se concentra em uma perspectiva analítico-reflexiva sobre obras escolares inseridas no Programa Nacional do Livro Didático (PNLD), mais precisamente na ramificação intitulada “PNLD 2012: Dicionários”, subdividida em quatro grupos de dicionários voltados ao Ensino Fundamental e Médio. Baseando-nos em Fajardo (1997), Strehler (1998), Garriga Escribano (2003), Welker (2004) e Gutiérrez Cuadrado (2011), analisamos as marcas de uso existentes nesse corpus. Constatamos uma não padronização da etiquetagem, o que, a nosso ver, pode gerar controvérsias durante a busca de um sentido dicionarizado por um consulente. Pretendendo contribuir para essa questão lexicográfica, propusemos um sistema de marcação dupla. Como resultado, inserimos nossa proposta em dez verbetes, tencionando sugerir algumas melhorias para futuras inclusões de marcas de uso nos dicionários escolares. (Apoio: CAPES – DS/CNPq – PD 2).
Etnobotánica de los criollos del Chaco Subhúmedo argentino I: Correspondencias botánico-fitonímicas y caracterización general de un nuevo complejo biocultural
Authors: Scarpa Gustavo F.
Published: July 2023

The general aim of this work is to distinguish and identify the Creole of the Argentine Subhumid Chaco as a new bio-cultural complex, to describe the botanical correspondences of their phytonymy, and to carry out a general characterization of their ethnobotany. Six field works were carried out between October 2017 and March 2022 in the center-north of Chaco Province. Classic ethnobotanical methodology was applied. This consisted of interviews and the collection of herbarium material with 51 collaborators from the area. A total of 541 matches between 369 botanical taxa and 457 types of vernacular names were obtained from 2075 reports; 1625 Criollos’ plant uses or meanings were registered. This refers to a total of 420 taxa throughout 4290 reports or mentions. Results from quantitative comparisons with Criollos’ phytonymic correspondences registered in neighboring areas of the Subhumid Chaco allow us to infer that the latter belong to the same bio-cultural complex proposed here. If we added these phytonyms to those obtained in the field it makes a total of 837 correspondences among 662 types of vernacular names assigned to 537 plant taxa, and three mushrooms. On the other hand, results of the quantitative comparisons between this phytonymy and those found in ethnobotanical investigations with Criollos from the Humid and Semiarid Chaco allow us to infer substantial differences between them, which reaffirms the condition of the Criollos of the Subhumid Chaco as a new bio-cultural complex.
Altered collagen I and premature pulmonary embryonic differentiation in patients withOItypeII
Authors: Storoni S. , Celli L. , Breur M. , Micha D. , Verdonk S. J. E. , Maugeri A. , van den Aardweg J. G. , Riminucci M. , Eekhoff E. M. W. , Bugiani M.
Published: July 2023

Pulmonary hypoplasia and respiratory failure are primary causes of death in patients with osteogenesis imperfecta (OI) type II. OI is a genetic skeletal disorder caused by pathogenic variants in genes encoding collagen type I. It is still unknown if the collagen defect also affects lung development and structure, causing lung hypoplasia in OI type II. The aim of this study was to investigate the intrinsic characteristics of OI embryonic lung parenchyma and to determine whether altered collagen type I may compromise airway development and lung structure. Lung tissue from nine fetuses with OI type II and six control fetuses, matched by gestational age, was analyzed for TTF‐1 and collagen type I expression by immunohistochemistry, to evaluate the state of lung development and amount of collagen. The differentiation of epithelium into type 2 pneumocytes during embryonic development was premature in OI type II fetuses compared to controls (p < 0.05). Collagen type I showed no significant differences between the two groups. However, the amount of alpha2(I) chains was higher in fetuses with OI and the ratio of alpha1(I) to alpha2(I) lower in OI compared to controls. Cell differentiation during lung embryonic development in patients with OI type II is premature and impaired. This may be the underlying cause of pulmonary hypoplasia. Altered cell differentiation can be secondary to mechanical chest factors or a consequence of disrupted type I collagen synthesis. Our findings suggest that collagen type I is a biochemical regulator of pulmonary cell differentiation, influencing lung development.
Caracterización molecular de la nueva entidad clínica relacionada con la hiperplasia suprarrenal congénita, síndrome CAH-X en población española
Authors: Martínez Figueras Laura , Muñoz Pacheco Rafael , García González Dolores , Arriba Domènech María , Ezquieta Zubicaray Begoña
Published: July 2023

Objetivos

La recombinación entre CYP21A2-TNXB y sus respectivos pseudogenes (CYP21A1P-TNXA) da lugar a quimeras responsables del síndrome CAH-X (SCAH-X). Los pacientes con este síndrome presentan manifestaciones clínicas de hiperplasia suprarrenal congénita (HSC) y síndrome de Ehlers-Danlos (SED). La descripción del SCAH-X es reciente y es limitado el número de estudios disponibles. El objetivo de este trabajo es poner a punto un abordaje para la detección de todos los tipos de quimeras CAH-X, determinar su frecuencia y la distribución en población española así como valorar la expresividad clínica en un grupo de pacientes.

Métodos

se seleccionaron 186 pacientes candidatos al estudio molecular CAH-X. Dicho abordaje molecular incluyó la técnica MLPA, detección de heterodímeros por electroforesis en gel capilar y secuenciación de exones 40, 41 y 43 de TNXB. La revisión de historias clínicas y la evaluación de signos y síntomas SED se ha llevado a cabo en 20 pacientes de tres Hospitales de referencia.

Resultados

Setentaiocho pacientes HSC presentaron quimeras CAH-X (41,9 %). Se detectaron 46 quimeras CH1 (24,7 %), 24 CH2 (12,9 %) y 8 CH3 (4,3 %), con una distribución geográfica no homogénea. Siete de los 20 portadores de quimera CAH-X valorados clínicamente (35 %) presentaron manifestaciones clínicas asociadas a SED.

Conclusiones

La implementación del abordaje molecular descrito en este trabajo ha permitido determinar el impacto del SCAH-X en población española. La expresividad clínica detectada y la considerable prevalencia del SCAH-X hacen recomendable el diagnóstico temprano de esta entidad para realizar un adecuado seguimiento de las manifestaciones clínicas que lo caracterizan.
Western Studies on the Sovietization of Eastern Europe
Authors: Zhu Xiaozhong
Published: July 2023

This paper reviews the studies of Western scholars on the Sovietization of Eastern Europe. Internationally, Sovietization was a significant component of the Soviet Union’s strategy in Eastern Europe after 1945. The Sovietization of Eastern Europe involved regulating international relations, defining the boundaries of these countries, determining the ethnic makeup of these countries through expulsion and population transfer, participating in the drafting of these countries’ constitutions, and deciding the composition of their governments. It is believed that Sovietization aimed to change all aspects of human experience and fundamentally rebuild cultural life, making the Soviet official ideology the guiding ideology of individual life in Eastern European countries. In the view of Western scholars, Sovietization led to two consequences. Firstly, it enabled the Soviet Union to hijack Eastern European countries to form the Eastern Bloc, and through COMECON and the Warsaw Pact, the Soviet Union long controlled Eastern European countries, causing the majority of them to become one side of the Cold War, to deviate from their original socio-economic development trajectory, and to become “The Other” of Europe. Secondly, Sovietization was incompatible with the historical, political, and economic traditions of Eastern European countries in many ways, resulting in Eastern European countries seeking development paths that were in line with their national characteristics and interests in different ways since the mid-1950s, and ultimately leading to dramatic changes in Eastern European politics from 1989 to 1991, completely abandoning the Soviet model and returning to the Western political and economic development models that existed in these countries between the two World Wars.
Optimization of hydrogel composition for effective release of drug
Authors: Pannala R. K. Pavan Kumar , Juyal Ujjwal , Kodavaty Jagadeeshwar
Published: July 2023

Hydrogels are possible materials that could be useful in medication delivery systems. Diverse release mechanisms are used when drug molecules embedded in the hydrogel structure need to be released. Both case I and case II of transport refer to the release of the medication during the intermolecular arrangement because of swelling. Numerous mathematical models have been proposed that only include one form of transport; nevertheless, both transport pathways are required for the entire release of a drug from a gel matrix. The case I transport during swelling and the case II transport during the fully swollen condition are both displayed by crosslinked hyaluronic acid hydrogel systems. The methodology put out in this paper enables for the selection of suitable gel compositions while attempting to account for both transit instances. In the Data Envelopment Analysis coupled with principal component analysis approaches are enable the optimization and selection of gel compositions that account for both transport situations.
Russian-Speaking Families and Public Preschools in Luxembourg: Cultural Encounters, Challenges, and Possibilities
Authors: Kanevskaya Daria
Published: July 2023

In the twenty-first century, multicultural encounters have become an experience that is familiar even to the youngest. In superdiverse trilingual Luxembourg, over 50% of the population are foreigners, and many of them do not speak the titular language of the country. Multicultural classrooms are studied very closely, but Russian-speaking students, a new but exponentially growing addition to the cultural mix, have not been studied yet in their journey of school integration. There is a gap between the parents and the teachers regarding perception of the content of the studies and family aspirations. Instruction in the Luxembourgish language, usually unfamiliar to Russian families, is not the only obstacle for a child to make good progress at school. The Slavic family group and the Cyrillic alphabet, different holiday calendar and traditions, as well as differences in behavioural patterns and educational models complicate the perception of implicit school rules both for the children and their parents. In this short ethnographic study, based on five in-depth semi-structured interviews with parents, qualitative data were analysed in order to single out the main challenges that Russian-speaking families face while adapting to the public Luxembourgish preschool, the first contact with Luxembourgish language and community life.
Leucaena leucocephala oil-based poly malate-amide nanocomposite coating material for anticorrosive applications
Authors: Al-Otaibi Wejdan , Alandis Naser M. , Alam Manawwer
Published: July 2023

This article describes the synthesis of polyesteramide (PEA) resin from Leucaena leucocephala oil (LLO) obtained from seeds of L. leucocephala tree, locally grown in King Saud University Campus. LLO was transformed into amide diol by based catalyzed amidation reaction, followed by esterification reaction with malic acid (MA), that resulted in LLO-based PEA (LPEA). The synthesis was performed without using any solvent or catalyst. Fourier-transformation infrared spectroscopy and nuclear magnetic resonance confirmed the formation of LPEA by the introduction of amide and ester moieties. LPEA was further reinforced with nano graphene oxide (GO) and fabricated into nanocomposite corrosion protective coatings (LPEA/GO). LPEA/GO coatings obtained were tough, flexibility retentive and showed good corrosion resistance performance toward 3.5 w/w% NaCl medium. Thermogravimetric analysis confirmed good thermal stability of coatings with safe usage up to 200°C.
粤港澳国际新闻语言特征计量对比研究
Authors: 许蕾  , 杜青
Published: July 2023

本文自建粤港澳国际新闻语料库，借鉴道格拉斯·拜伯的多特征方法，通过多种计量工具对《广州日报》《文汇报》《澳门日报》的标准型/次比、高频词、低频词、词型覆盖率、词长、词汇密度、词类分布、句长等进行统计分析。结果表明，三地媒体国际新闻语言在高频词、词型覆盖率、词长、词类分布等方面存在一定共性，在标准型/次比、词汇密度、句长等层面存在较大差异，而《文汇报》的语言区别性特征更加突出。
自然口语中两岸模糊限制语的比较
Authors: 张 晶
Published: July 2023

提要

模糊限制语是言语交际的重要语用策略, 然而鲜有研究去探讨汉语模糊限制语运用的地域差异。因此本文以两岸汉语的口语会话语料为依据, 实证调查了两岸青年人模糊限制语使用的异同。结果发现, 除间接缓和语和范围变动型模糊限制语外,其他类型模糊限制语的使用频率和具体用法均存在较明显的两岸差异。但由于密切的语言接触, 有些两岸原来有差异的模糊限制语已经出现用法上的趋同, 这在一定程度上反映了两岸汉语逐渐融合的趋势。
The characteristics of spelling difficulties for Chinese students
Authors: Zhao Ningning , Li Yanhua , Li Ping , Zhong Kunlin , Desoete Annemie , Zhang Qiuling
Published: July 2023

The study explored the characteristics of students with spelling difficulties in China. According to the international classification of diseases and related health problems Tenth Edition (ICD-10) on the spelling difficulties, there were 7 students with spelling difficulties (means of age = 107.71 months old) selected from total 146 students (means of age = 107.59 months old). The results showed that, spelling difficulties group had more no response errors than the typical speller group. And the SD group and TS group had the same patterns in the no response answers considering the orthographic structure. But the SD group could not make use of the implicitly orthographic structure for the detail while TS group could do. The results confirmed that the SD group had deficit in orthographic-phonographic connections and the information of orthographic structure might work in the whole characters level for SD group. It gave some suggestions for the impairment for the SD group.
The punishment is the reward – why elite Chinese students take supplementary Chinese literacy tutoring despite viewing it as ineffective
Authors: (雨婷 张)  , (小颖 许)
Published: July 2023

Reward and punishment are basic concepts in psychology. To survive better, humans and animals often need to maximize rewards and minimize punishments and threats. The human brain makes judgments about rewards and punishments based on distinguishing among complex environmental factors and makes decisions about future actions accordingly. Chinese students have spent more than a decade of primary and secondary school education with purposeful, fine-grained time management learning with the goal of success on the college entrance exam (Gaokao). The relationship between rewards and punishments for literacy tutoring at the primary and secondary school levels and the decision-making behavior of students and parents is therefore a question worth exploring. The purpose of this paper is to explore the decision-making mechanisms of elite Chinese students’ participation in or withdrawal from literacy tutoring in Chinese and the factors behind the reward and punishment mechanisms through grounded method analysis. The results show that most elite students and their parents do not believe that language literacy tutoring will significantly improve their chances for better college entrance exam scores, but there is a complex relationship between their decision-making behavior in tutoring and the reward and punishment mechanisms. Literacy improvement, emotional values, parent-child support obligations and even face-saving culture all contribute to students’ and parents’ decision-making behaviors. Choosing tutoring that is not seen as likely to improve test scores is a common phenomenon, which suggests that the punishment itself provides the reward that drives decisions to pursue literacy tutoring.
Investigating the effects of varying Accelerative Integrated Method instruction on spoken recall accuracy: a case study with junior primary learners of French
Authors: Carey Michael D. , Rugins Ojars , Grainger Peter R.
Published: July 2023

This study investigated the effect of using the Accelerative Integrated Method (AIM), with or without additional revision and video-guided practice, on junior primary students’ spoken recall accuracy in French. The same beginner AIM French activities were taught by a language specialist to 12 classes in four junior primary levels. Three different conditions of instruction were used each week: (1) one session of AIM instruction, (2) one session of AIM instruction plus one session of revision, and (3) one session of AIM instruction, plus one session of revision, and three sessions of video input. The instruction and revision sessions were facilitated by a language teacher, whereas the video sessions were played by the main class teacher. A two-way ANOVA revealed that Year 1 students benefited from a revision session with the language teacher, but Prep and Year 1 did not benefit from further video exposure. Conversely, the Years 2 and 3 students did not benefit from extra revision with the language teacher, but they did benefit from additional video exposure. Direct observation of the student response to the AIM suggested that the pace of the program needed to be slower for the younger learners.
Modulation of glucose metabolism-related genes in diabetic rats treated with herbal synthetic anti-diabetic compound (α-HSA): insights from transcriptomic profiling
Authors: Khurana Nikhil , Sharma Suman Bala
Published: July 2023

Objectives

Eugenia jambolana is a medicinal plant traditionally used for treating diabetes. The bioactive compound FIIc, which is derived from the fruit pulp of E. jambolana, has been identified and purified as α-HSA. Previous studies have demonstrated that administration of α-HSA for 6 weeks improved glycemic index and dyslipidemia in rats with T2D. This study investigated the molecular mechanism underlying the potential therapeutic effects of α-HSA in experimentally induced diabetic rats.

Methods

Male Wistar rats were divided into four groups: diabetic control, diabetic treated with FIIc, diabetic treated with α-HSA, and diabetic treated with glibenclamide. Over a 6-week experimental period, transcriptomic analysis was conducted on liver, skeletal, and pancreatic tissue samples collected from the rats.

Results

The study findings revealed significant upregulation of genes associated with glucose metabolism and insulin signaling in the groups treated with FIIc and α-HSA, compared to the diabetic control group. Moreover, pro-inflammatory genes were downregulated in these treatment groups. These results indicate that α-HSA has the potential to modulate key metabolic pathways, improve glucose homeostasis, enhance insulin sensitivity, and alleviate inflammation.

Conclusions

This study provides compelling scientific evidence supporting the potential of α-HSA as a therapeutic agent for diabetes treatment. The observed upregulation of genes related to glucose metabolism and insulin signaling, along with the downregulation of pro-inflammatory genes, aligns with the pharmacological activity of α-HSA in controlling glucose homeostasis and improving insulin sensitivity. These findings suggest that α-HSA holds promise as a novel therapeutic approach for managing diabetes and its associated complications.
Dynamic response of a two-story steel structure subjected to earthquake excitation by using deterministic and nondeterministic approaches
Authors: Dows Mustafa Qasim , Al-Baghdadi Hayder A.
Published: July 2023

An earthquake is a random phenomenon in its intensity and frequency content. Since the earthquake is a signal that contains a band of frequencies, each frequency has a different energy. This means that the response of buildings to earthquakes depends not only on the intensity of the earthquake but on its frequency content as well. In this study, two different approaches have been used: deterministic approach which is the time history analysis to show how the intensity of earthquakes affects the building response, and the nondeterministic random vibration approach, which is to clarify the response in the frequency domain and to show the effect of dominant frequencies of the earthquake. Both a prototype and a 1:6 scaled model was used to simulate a two-story steel building. In the experiential part, a shaking table was used to simulate a 1:6 scaled El-Centro 1940 NS earthquake as a base excitation with different intensities (0.05, 0.15, and 0.32g). In the theoretical part, Abaqus software was adopted to simulate the numerical model of the building. The results showed that the deterministic approach may be a non-conservative approach.
Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
Authors: Duan Qi , Wu Junxia
Published: July 2023

Dihydroartemisinin (DHA) has been found to inhibit the expression of von Willebrand factor (VWF), a marker of endothelial cell injury, but its mechanism in cerebral ischemia/reperfusion (I/R) injury remains obscure. In this study, I/R model was constructed through middle cerebral artery occlusion (MCAO) in rats, followed by DHA administration. The effect of DHA on rat cerebral I/R injury was investigated by 2,3,5-triphenyltetrazolium chloride staining, hematoxylin and eosin staining, TUNEL staining, and Western blot. Brain microvascular endothelial cells (BMVECs) isolated from newborn rats were exposed to oxygen–glucose deprivation/reoxygenation (OGD/R), and then treated with DHA. The results showed that MCAO treatment induced infarction, nerve cell apoptosis, and brain tissue impairment in rats, which was mitigated by DHA. OGD/R inhibited viability and accelerated apoptosis of BMVECs, which was alleviated by DHA. I/R procedures or OGD/R up-regulated expressions of VWF, ATG7, Beclin1, and LC3-II/LC3-I ratio, while down-regulating Occludin, Claudin-5, ZO-1, P62, SIRT1, and FOXO1 expressions in vivo and in vitro; however, these effects of I/R procedures or OGD/R were offset by DHA. VWF overexpression reversed the above effects of DHA on OGD/R-induced BMVECs. In summary, DHA ameliorates cerebral I/R injury in rats by reducing VWF level and activating autophagy-mediated SIRT1/FOXO1 signaling pathway.
Production of high content of N-methyldiethanolamine di-ester via heterogeneous transesterification
Authors: Aziz Haliza Abdul , Yusoff Rozita , Cheng Ngoh Gek , Idris Zainab , Syahirah Ramli Nur Aainaa
Published: July 2023

A heterogeneous transesterification over a Zn-doped CaO catalyst was developed as a new alternative route to conventional homogeneous catalysis for the production of N-methyldiethanolamine-based esterquats. In this study, the optimum heterogeneous transesterification conditions for the production of N-methyldiethanolamine di-ester, a precursor of esterquats, in high yield were determined. At a temperature of 143 °C, a vacuum of 288 mbar, a molar ratio of 2:1 (methyl ester:N-methyldiethanolamine) and a catalyst dosage of 6 %, a maximum N-methyldiethanolamine di-ester yield of 83 % was obtained. The reused catalyst showed consistent activity in three consecutive runs, demonstrating the robustness of the Zn-doped CaO catalyst in the transesterification process. This route can reduce production costs due to the reusability of the catalyst and the elimination of water consumption in the neutralisation process for catalyst removal.
ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein
Authors: Szabo Leonora , Cummins Nadia , Paganetti Paolo , Odermatt Alex , Papassotiropoulos Andreas , Karch Celeste , Götz Jürgen , Eckert Anne , Grimm Amandine
Published: July 2023

Abnormal tau protein impairs mitochondrial function, including transport, dynamics, and bioenergetics. Mitochondria interact with the endoplasmic reticulum (ER) via mitochondria‐associated ER membranes (MAMs), which coordinate and modulate many cellular functions, including mitochondrial cholesterol metabolism. Here, we show that abnormal tau loosens the association between the ER and mitochondria in vivo and in vitro. Especially, ER‐mitochondria interactions via vesicle‐associated membrane protein‐associated protein (VAPB)—protein tyrosine phosphatase‐interacting protein 51 (PTPIP51) are decreased in the presence of abnormal tau. Disruption of MAMs in cells with abnormal tau alters the levels of mitochondrial cholesterol and pregnenolone, indicating that conversion of cholesterol into pregnenolone is impaired. Opposite effects are observed in the absence of tau. Besides, targeted metabolomics reveals overall alterations in cholesterol‐related metabolites by tau. The inhibition of GSK3β decreases abnormal tau hyperphosphorylation and increases VAPB–PTPIP51 interactions, restoring mitochondrial cholesterol and pregnenolone levels. This study is the first to highlight a link between tau‐induced impairments in the ER‐mitochondria interaction and cholesterol metabolism.
The Existence of Pyong Pyong Band in Semarang
Authors: Dananjaya Muhammad Fajar Aji , Muttaqin Moh
Published: July 2023

Pyong Pyong Band is a pop punk band from Semarang formed on December 8, 1999. The purpose of this research was to describe and discuss the existence and the efforts of Pyong Pyong band to maintain its existence. This study used a phenomenological approach and qualitative methods. Data collection techniques were carried out through the stages of observation, interviews and documentation. Based on the results of the research and discussion, it was concluded that Pyong Pyong Band still exists today. This is evidenced by the increasing recognition by the public of the works of Pyong Pyong Band, including the number of Instagram followers which reached 3,806. Furthermore, to maintain its existence, Pyong Pyong Band makes efforts through activities by continuing to work in music, collaborating, and utilizing various social media in establishing communication with their fans as well as a medium to popularize his works.
Microglia-Mediated Neuroinflammation in Parkinson’s Disease
Authors: Bulls Vila
Published: July 2023

Parkinson’s disease (PD) is an age-related neurodegenerative disease, and its main pathological feature is the specific reduction of dopamine neurons in the substantia nigra of the midbrain and α-synuclein aggregates. However, the specific molecular mechanism of the degeneration of dopamine neurons in the substantia nigra is still not fully understood. Neuroinflammation is involved in the development of PD, and microglia-mediated neuroinflammation plays an important role in the degeneration of dopamine neurons. This article will review the mechanism of microglia-mediated neuroinflammation in the pathological process of PD, and provide new understanding for the molecular mechanism and treatment of PD.
Evaluation of Science Teachers’ Exam and High School Entrance Exam Science Questions Based on the Revised Bloom Taxonomy
Authors: Koman Ismail , Bayrakceken Samih , Oktay Ozlem , Canpolat Nurtac
Published: July 2023

This study aims to evaluate exam questions set by science teachers for eighth grade students and science questions from a central high school entrance exam (HSEE) according to the Revised Bloom’s Taxonomy (RBT). In this study, document analysis technique was employed, as one of the recognized methods of qualitative research. The HSEE science questions and the teacher-prepared exam questions were evaluated separately in the dimensions of knowledge and cognitive process, and the frequency and percentage distribution of the questions were examined according to the RBT. The science teachers’ exam questions were found to be the most suitable for factual knowledge in the RBT knowledge dimension, and the most appropriate for the remembering and understanding levels of the cognitive process dimension. It was determined that the HSEE science questions were the most suitable for conceptual and procedural types of knowledge in the RBT knowledge dimension, and for the understanding and analyzing levels in the cognitive process dimension. Both the questions prepared by teachers and the HSEE science questions were not homogeneously distributed in terms of the RBT. It was determined that while the science teachers’ exam questions were at the lower level of the cognitive process, the HSEE science questions were at a level higher than those prepared by the teachers.
Industrieportfoliooptimierung
Authors: Auer Benjamin R.
Published: July 2023

Wird durch die Verteilung von Investitionskapital auf Aktien verschiedener Industrien der Fokus auf einzelne Industriesektoren aufgegeben, lassen sich Investitionsergebnisse (im Hinblick auf Risiko und Risikoprämie) oft entscheidend verbessern. Die aktuelle Grafik illustriert das Ausmaß derartiger Verbesserungseffekte, die ideale Kapitalauf­teilung in Industriekombinationen und die Wirkung typischer praktischer Restriktionen (wie zum Beispiel Leerverkaufsverbote) in diesem Kontext.
El utilitarismo y la subjetividad moderna
Authors: Trucco Ignacio
Published: July 2023

El utilitarismo constituye la filosofía moral de base sobre la que se levanta la teoría económica marginalista, la más aceptada en el campo disciplinar. Diferentes perspectivas han objetado su validez negando que el utilitarismo refleje adecuadamente la realidad intersubjetiva que se pone en actividad a la hora de producir fenómenos económicos. Sin embargo, resulta menos conocida la crítica que puede deducirse del sistema filosófico de Hegel, en particular, de su filosofía del espíritu subjetivo. Este trabajo compara estas dos filosofías morales tomando como eje articulador la tensión entre deseo, cultura y libertad y sus consecuencias para las investigaciones económicas.
Modeling of Cyber Threats Related To Massive Power Outages and Summary of Potential Countermeasures
Authors:   G.E. Pukhov Institute for Modelling in Energy Engineering  National Academy of Sciences of Ukraine, Kyiv, Drahuntsov R. , Zubok V. ,   G.E. Pukhov Institute for Modelling in Energy Engineering  National Academy of Sciences of Ukraine, Kyiv
Published: July 2023

During the Russian-Ukrainian war, mass power outages occurred in Ukraine, caused by Russian attacks on civilian infrastructure, namely on the generating and distribution capacities of the power system. The risks associated with such outages cover not only the issue of uninterrupted operation of the economy directly, but also more complex aspects related to cyber security. The impact of such outages on the cyber security of information and communication systems is con-sidered, namely, the second-order effects, such as interruptions with information observability, violation of the integrity of the protection infrastructure, overloading of monitoring teams and response to false alarms. All these factors alter the threat landscape for the system and must be considered in security policy and during the threat modeling process accor¬dingly. An analysis of hidden cyber security risks arising in connection with massive power outages was conduct-ed. Possible approaches to taking such risk factors into account when modeling threats, as well as methods of countermeasures, are given.
Metachromatic, tryptase- and ghrelin-positive mast cells in the blood vessels of rat’s lung
Authors: Ivanova I. G.
Published: July 2023

Mast cells and the mediators they release play a major role in the pathogenesis of lung diseases. They regulate the function of the smooth muscle layer of the pulmonary airways and the same layer of the blood vessels. There are no data about the distribution of metachromatic and tryptase-positive mast cells in the blood vessels’ wall as well as on the content of ghrelin in mast cell granules in rat’s lung. The aim of this research was to present an analysis of the number and localisation of tryptase-positive, ghrelin-positive and metachromatic mast cells in the blood vessels (arteries, capillaries, venules and veins) in rats of different age. Six male Wistar rats were used for each age group - 20 days, 3 months and 1 year. Tissue slices for histochemical examination were taken from the caudal lobe of the left lung and stained with toluidine blue. Immunohistochemical reactions were then performed to indicate the expression of tryptase and ghrelin, allowing comparing the presence of tryptase-, ghrelin-positive and metachromatic mast cells in the wall of the blood vessels of different diameters. The light microscopical study showed that in all types of blood vessels from the three age groups, the number of ghrelin positive cells was the largest, followed by tryptase-positive and metachromatic mast cells. The observed differences in the distribution of these cells are important for maintaining the lung homeostasis and can be used as reference values in experimental studies in order to obtain accurate results.
Computational wind analysis of an open air-inflated membrane structure
Authors: Pool-Blanco Sherly Joanna , Hincz Krisztián
Published: July 2023

The current research aimed to obtain mean pressure distribution over an air-inflated membrane structure using Computational Wind Engineering tools. The steady-state analysis applied the Reynolds-Averaged Navier-Stokes equations with the standard turbulence model. The pressure coefficients were compared with former experimental results to validate the numerical solution. Significant errors were detected close to the critical flow separation points when comparing the numerical results with the wind tunnel tests. However, these errors are local, and the numerical methodology provides accurate results in those areas with minor turbulence motion influence. In general, the numerical solution provided good approximation of the pressure coefficient fields.
Genome mining reveals chitin degradation potential of \(\textit{Streptomyces parvulus}\) VCCM 22513
Authors: Ngoc Tung Quach , Thu An Nguyen Thi , Hanh Nguyen Vu Thi , Quyet Tien Phi
Published: July 2023

The genus Streptomyces is not only known as a natural producer of antibiotics but also a prolific source of chitinolytic enzymes that digest recalcitrant chitin to chitooligosaccharides. However, only a few reports have used whole-genome sequencing to study chitin degradation of Streptomyces to date. In the present study, out of 22 Streptomyces strains, Streptomyces parvulus VCCM 22513 produced the highest chitinase activity. Time courses of incubation revealed that the maximum chitinase (0.91 ± 0.04 U/mL) of this strain was observed after 96 hours in the yeast extract salts medium supplemented with 10.0 g/L colloidal chitin. Additional genomic analysis of VCCM 22513 was also conducted to discover the genomic information related to chitin degradation. The VCCM 22513 genome consists of 341 CAZy genes divided into 6 families including glycoside hydrolase (134 genes), carbohydrate-binding module (88 genes), glycosyl transferase (87 genes), carbohydrate esterase (18 genes), polysaccharide lyase (7 genes), and auxiliary activity (7 genes). Further genome mining revealed the presence of 10 chitinases, 4 lytic polysaccharide monooxygenases, and 14 β-N-acetylhexosaminidases, which mainly contribute to the degradation of chitin polymers. This is the first report revealing the mechanism underlying the chitin degradation of S. parvulus. Further investigations are required to characterize chitinolytic enzymes found in this study for the bioeconomic production of high-quality chitooligosaccharides from chitin food wastes.
Implementasi Blue Economy di Wilayah Pesisir Kenjeran Surabaya
Authors: Mukaromah Hani , Rahmawati Lilik
Published: July 2023

This study aims to explain the implementation of the blue economy concept in the Kenjeran coastal area of ​​Surabaya. This research uses a descriptive method with a qualitative approach. The type of data used is primary and secondary data. Primary data obtained from observation and interviews with informants. Secondary data comes from literature reviews on official government websites, previous research journals, scientific papers, and other literacy sources. The results of the study reveal that of the 4 principles and indicators that serve as a reference for implementing the blue economy concept in the Kenjeran coastal area of ​​Surabaya, there are 3 principles that have been implemented and 1 principle in the pursuit stage.
Factors Influencing Consumer Attitude Towards Luxury Perfumes in Kolkata
Authors: Sengupta Angshuja , Sadhu Nilabha
Published: July 2023

Luxury, in its most basic form can be described as a complicated phenomenon based on the human impulse to satisfy one's desire for aesthetic pleasure and self-expression while also wishing to be appreciated and respected by others. It might vary based on the individual, the product,
and the situation. When it comes to luxury brand consumption, customers can express themselves (through the value-expressive function) as well as display themselves (via the social-adjusted function) in front of others (via the social-adaptive function). The focus of this investigation is
on perfumes or scents. Fragrances are featured in the portfolios of all luxury brands, and they are utilized as part of their strategy for brand extension. In this backdrop this study will mainly focus on four major factors namely uniqueness, status, hedonic value and materialism on consumer
attitude in Kolkata, India market towards luxury perfume. The objectives of this study are firstly to explore the factors that influence attitude towards purchasing luxury perfumes and secondly to measure the impact of factors of attitude towards purchasing luxury perfumes.
Exploring Consumer Purchase Intention Towards Green Electrical Equipment With Special Reference To Green Electrical Fan
Authors: Dutta Baivab , Das Soumika , Khan Poushali , Souvik  , Bhattacharya Anala , Chattaraj Dibyendu
Published: July 2023

Purpose: To study the consumer perception on green electrical equipment and to know consumer perception on overall experience towards green electrical equipment and further investigate the moderating effects of green brand knowledge. to study the green purchase intention and
green positioning.Methods: The Non-Probability Judgemental Sampling, considering the limitations of time, financial supports, and other resources.Findings: From this study it is implicated that consumers purchase intention towards green electrical equipment. This study
statistically proved that consumers are aware about the green products and it results in willingness to try green products. At the same results investigated that consumers using green products are more conscious than the consumers using traditional products.Implications: Throughout
the world, "new technology business models" that are tied to clean technologies offer consumers and investors competitive returns while addressing global concerns (UNEP, 2021). Research study observed positive and favourable purchase intention of consumers towards green fans.Originality:
Today, most people shy away from making a change in their lives without knowing how beneficial it is to them. When you adopt an environmentally-mindful lifestyle, it offers several benefits.
Discrimination of different Citronella essential oil samples depending on citronellal using QCM based Sensor
Authors: Kundu Sumit , Gangopadhyay Deepam , Moulick Madhurima , Bhattacharyya Banerjee Mahuya , Roy Runu Banerjee
Published: July 2023

Citronella oil derived from the leaves and stems of various Cymbopogon species (lemongrass) finds widespread application in the soap, candles, incense, perfumery, cosmetic, and flavouring industries worldwide. It is also used as insect repellent and non-toxic bio pesticide. The present
study employs a QCM-based sensor to discriminate different samples of citronella essential oil depending on the content of citronellal present in each sample. Citronellal is the main component and has the highest concentration in citronella essential oils. Aside from citronellal, the oil also
contains citronellol and geraniol. For the development of the sensing film Methyl Acrylate, Acrylic acid, Divinyl Benzene and Tung oil are used. The analytical performance of the sensor found reasonably good with sensitivity 0.075Hz/ppm. Principal component analysis (PCA) was used to distinguish
between four varieties of citronella essential oil. The PCA plot revealed a satisfactory clustering separability of the four different samples.
COMPARISON OF THE SPECIFIC IMPULSE CALCULATED WITH THE ISPBKW CODE AND TWO DIFFERENT EMPIRICAL RELATIONSHIPS ENCODED INTO THE RESEARCH OUTPUT SOFTWARE FOR ENERGETIC MATERIALS BASED ON OBSERVATIONAL MODELING (ROSEBOOM): THE ROSEROCKET UPDATE
Authors: Wahler Sabrina , Klapötke Thomas M.
Published: July 2023

In this study, we compared the specific impulses of the ISPBKW code to two empirical models. The ISPBKW code can be easily accessed using the RoseBoom© application programming interface. For example, it took less than 3 minutes to generate all of the results presented in this paper.
Bearing characteristics of model piled raft foundations supported by sheet piles
Authors: Xiong Xi , Guo Wentao , Matsumoto Tatsunori , Ishihara Yukihiro
Published: July 2023

Recently, with the development of new piling methods, steel sheet piles can be penetrated into various types of ground with high quality and precision. Although pipe piles are used for piled raft foundations, sheet piles could become an alternative. Thus, the aim of this research study is to demonstrate the possibility of using sheet piles for piled raft foundations. In this study, a series of model tests was carried out first to investigate the load transfer behaviours of model piled raft foundations supported by three types of piles in an air-dried sand ground. Two of them were composed of sheet piles, called plate piles and box piles, respectively, and the other was composed of conventional pipe piles for comparison. Both vertical and horizontal load tests were carried out, and the load sharing between the raft and piles was carefully investigated. As the plate pile foundation (PPF) exhibited outstanding behaviours, numerical analyses were carried out using finite-element methods to investigate the foundation–soil interaction in PPFs. According to test and calculated results, a piled raft foundation supported by sheet piles would be a promising alternative to a conventional pipe pile foundation, especially in highly seismic areas.
ISOLATION AND PURIFICATION OF ISOPRENE FROM CYCLOPENTADIENE
Authors: Shevlyakov Fedor B. , Kildibekova Karina R. , Terechshenko Nikita V. , Litvyakov Ivan S. , Samarkina Aleksandra B.
Published: July 2023

Isoprene is a basic monomer in the petrochemical industry. It is used in the synthetic rubber production for the manufacture of rubber products for the electrical, aviation and engineering industries, for the manufacture of food and medical products. In the Republic of Bashkortostan, Sintez-Kauchuk OJSC (Sterlitamak) produces isoprene by the two-stage dehydrogenation of isopentane with an annual product output of hundreds of thousands of tons. The disadvantage of this technology for producing isoprene is the significant content of impurities in raw isoprene, which seriously affect the kinetics of polymerization and the quality of the final product. Of all the impurities present in the monomer, cyclopentadiene is the most detrimental to the stereoregular polymerization process. Its content in isoprene should not exceed 0.0001 % wt. Due to the urgency of the problem, a technical solution was developed to remove cyclopentadiene impurities from monomers.Currently, there is a problem of accumulation of cyclopentadiene in the system of purification and treatment of isoprene at the operating production. The paper proposes to purify isoprene from cyclopentadiene before the stage of extractive distillation. This purification method allows to reduce the content of cyclopentadiene in the isoprene-isoamylene fraction from 0.10 % wt. to 0.00014 % wt, which reduces its concentration in all recycle flows of the isoprene isolation and purification system. To implement this solution, laboratory experiments were carried out to purify the isoamylene-isoprene fraction formed at the second stage of isopentane dehydrogenation. In order to assess the energy efficiency of the studied method for reducing cyclopentadiene, a computer model of the isoprene isolation and purification process was built in the Honeywell Unisim Design software environment.
APPLICATION OF THE RN-GEOSIM SOFTWARE PACKAGE IN HIGHER EDUCATION ESTABLISHMENTS
Authors: Krasnoperova Svetlana A. , Karimova Elena N. , Antonov Maxim S. , Volkov Maksim G.
Published: July 2023

The article discusses the practical use of the PH-GEOSIM corporate software package in the educational process on the example of higher educational establishments. This complex was developed as part of import substitution in RN-BashNIPIneft LLC, the corporate institute of Rosneft. It is designed to build and maintain geological models of oil and gas fields, contains modern visualization tools that help the geologist-modeler in his work and display the components of the geological model in 1D (correlation scheme), 2D projections, 3D view. The RN-GEOSIM software package, which has all the necessary functionality for working with digital geological models, will allow students to develop general professional competencies of educational programs in accordance with their specialization at a basic and advanced level.
Examination of EPGBU model proposed for academically gifted student with structural equation model
Authors: SAVAŞ Baran , GÖĞEBAKAN YILDIZ Derya , TORTOP Hasan Said
Published: July 2023

The fact that gifted education programs have certain standards, include evaluation, and are based on theoretical foundations ensure that these programs are real programs. Therefore, it is necessary to test the effectiveness of the programs put forward for gifted education and to determine their social validity. The Education Program for Gifted Bridge with University (EPGBU), developed by Tortop (2013), is a university-based program aimed at raising gifted students in the academic field. This research is in a descriptive survey model, and the characteristics of gifted students studying at the Science and Art Center in Turkey in the components of the EPGBU model were analyzed with the Structural Equation Model (SEM). EPGBU model values; χ2=4.328, df=5, p=.000; RMSEA, 0.000; χ2/df=,866; NFI=.951; CFI=.50; GFI=0.983; PCLOSE= .000 was found. Accordingly, it is seen that the EPGBU model is a fit model.