bluuebunny/crossref_metadata_2025 huggingface dataset:
КОНТЕКСТИ СТРУКТУРНО-ПРОСТОРОВОГО РОЗВИТКУ ТУРИСТИЧНО-РЕКРЕАЦІЙНОЇ СФЕРИ
Authors: Романів Павло
Published: May 2024

Структурно-просторовий розвиток туристично-рекреаційної сфери описує процес формування та розподілу туристичних об'єктів та інфраструктури на певній території з урахуванням її географічних, економічних, культурних та інших характеристик, процесів та явищ. Цей процес включає в себе розробку туристичних маршрутів, створення та модернізацію готельно-ресторанної бази, розвиток транспортної інфраструктури, створення розважальних та культурно-пізнавальних об'єктів та подій тощо. Проте, аналітична складова дослідження розвитку туристично-рекреаційної сфери на нашу думку передбачає контексти, що є пререквізитами такого розвитку, особливо у мінливому середовищі за умови дії негативних факторів: війна та її наслідки, екологічні та демографічні проблеми, безпекова ситуація, доступність території тощо. Наша стаття саме присвячена розгляду таких контекстів, що згруповані за певними критеріями: об’єктно-предметними, ціннісними, функціональними, географічними, безпековими, інституційними, екологічними. Наголошуємо також на тому, що ці сенси об’єднані тим, що є комплементарними, а не взаємозамінними. Тобто, кожен окремий критерій (сенс) не може замінити відсутність чи слабкий розвиток іншого. Головне завдання дослідників – синергійно об’єднати, інтегрувати складові структурно-просторового розвитку на різних рівнях територіальної організації регіону – від територіальної громади (ТГ) чи населеного пункту до об’єднання областей чи специфічних організацій типу Destination marketing (or management) organization (DMO). Аналіз контекстів відбувається крізь призму війни в Україні, що має серйозний вплив на туризм та рекреаційну сферу, має негативний і довгостроковий ефект: екологічний, безпековий, іміджевий, через руйнування, відтік населення та робочої сили. Також важливим є екологічний контекст. Розвиток туристично-рекреаційної сфери в екологічному контексті стає дедалі більш значимим у світі, де зростає усвідомлення людьми необхідності збереження (подекуди відновлення) навколишнього середовища та його компонентів. Ефективний структурно-просторовий розвиток туристично-рекреаційної сфери сприятиме створенню стійкого та конкурентоспроможного туристичного продукту, який забезпечує економічний зріст та підвищення якості життя місцевого населення.
ІНТЕГРАЦІЯ ЗНАНЬ З БІОМЕХАНІКИ У ПРОФЕСІЙНУ ПІДГОТОВКУ МАГІСТРІВ СТОМАТОЛОГІЇ
Authors: Прохоренко Ігор Артемович
Published: May 2024

У роботі наведено результати дослідження перспектив інтеграції знань з механіки та біомеханіки в професійній підготовці майбутніх магістрів стоматології. Обґрунтовано зміст та структуру вибіркової навчальної дисципліни «Біомеханіка зубо-щелепного апарату. Фізичні основи гнатології». Впродовж останніх трьох десятиліть спостерігається відчутний прогрес у стоматології, який не обмежується технологічними новаціями, а характеризується також переналаштуванням стоматології в біофізичному, фізіологічному контексті. Значна частка стоматологічних захворювань та ускладнень пов’язана з недостатнім знанням біомеханіки опорно-рухового та зубо-щелепного апарату та розумінням багатофункціональності взаємозв’язків елементів та тканин зубо-щелепної системи в нормі та при патології, неправильним використанням цих знань у реконструктивній стоматології, діагностиці та профілактиці стоматологічних захворювань. Актуальність таких досліджень в Україні істотно посилюється через збільшення кількості пацієнтів, травмованих у війні, яку розв’язала рф на нашій території. Проаналізувавши освітньо-професійні програми та навчальні плани провідних медичних закладів вищої освіти, нами було з’ясовано, що питання інтеграції знань механіки та біомеханіки в професійній підготовці магістрів стоматології є своєчасними і актуальними та потребують системного комплексного підходу до їхнього вивчення. Було проведено обговорення у фокус-групах, до складу яких входили студенти старших курсів спеціальності 221 «Стоматологія», викладачі профільних кафедр стоматологічного факультету, практикуючі лікарі-стоматологи. У кожній з фокус-груп для обговорення було зроблено акцент на певний аспект досліджуваної проблеми: розуміння сутності основних законів біомеханіки та їх ролі для майбутньої професійної діяльності; частота звертань пацієнтів з проблемами, вирішення яких потребувало компетентностей з гнатології; потреба створення спеціальної навчальної дисципліни, її обсяг, зміст, місце в навчальному плані. Проведені дослідження, а також вивчення зарубіжного досвіду засвідчили потребу розроблення вибіркової навчальної дисципліни, яка б була базою для системної інтеграції знань з біомеханіки у професійній підготовці магістра стоматології і створили передумови для розроблення її змісту та структури.
Cladistic species definitions can lead to under-representation of biodiversity from adaptive radiations
Authors: Turner George
Published: May 2024

Many species are paraphyletic, but current taxonomic practices often do not recognise this, and attempts are made to apply a monophyletic species concept. While allowing the recognition of ecomorphologically equivalent, or even phenotypically indistinguishable allopatric taxa as species, this often leads to combining distinctive local forms (such as cave-adapted populations) or even whole adaptive radiations (often in lakes) with widespread paraphyletic species to force species monophyly. It is suggested that this has negative consequences for our documentation and understanding of biodiversity, as well as for conservation, through issues such as lack of IUCN redlisting.
REGULASI TATA KELOLA WISATA DESA BENTENG KOTA
Authors: Toni Toni , Hutapea Sintong Arion , Sarpin Sarpin
Published: May 2024

Desa Benteng Kota terletak di wilayah Kecamatan Tempilang Kabupaten Bangka Barat. Terdapat 3 potensi daerah tujuan wisata utama yang berada di Desa Benteng Kota. Pulau Semubung dan Pantai Gelam, Benteng Kota dan Festival Perang Ketupat. Pengembangan pariwisata di Desa Benteng Kota meliputi peningkatan kesadaran kepada masyarakat di Desa Benteng Kota. Disamping itu juga, basis pengembangan pariwisata wajib menggunakan nilai kearifan lokal. Diperlukan juga pembentukan badan hukum yang mewadahi pengembangan pariwisata di Desa Benteng Kota. Badan hukum ini akan bisa melakukan perbuatan hukum seperti subyek hukum.
PENDAMPINGAN IBU HAMIL DALAM PERSIAPAN MENYUSUI DAN PEMBERIAN MAKAN BAYI DAN ANAK (PMBA) USIA 6-24 BULAN DI REJOMULYO KECAMATAN JATI AGUNG KABUPATEN LAMPUNG SELATAN
Authors: Putriana Yeyen , Risneni Risneni , Sulistianingrum Lely
Published: May 2024

Masa sejak konsepsi hingga dua tahun pertama kehidupan anak merupakan periode emas yang menentukan kualitas kehidupan. Nutrisi yang adekuat selama periode tersebut menjadi dasar bagi perkembangan potensi setiap anak. WHO (World Health Organization) merekomendasikan Pemberian Makan pada Bayi dan Anak (PMBA) yang tepat meliputi Inisiasi Menyusu Dini (IMD) segera setelah lahir minimal selama 1 jam, pemberian Air Susu Ibu (ASI) eksklusif sampai usia 6 bulan, memberikan Makanan Pendamping ASI (MP-ASI) mulai usia 6 bulan, dan meneruskan pemberian ASI sampai usia 2 tahun atau lebih.Kegiatan Pengabdian masyarakat ini bertujuan untuk memberikan pendampingan dan edukasi kepada ibu hamil dan ibu menyusui di Posyandu Melati Rejomulyo, mengenai pentingnya persiapan menyusui dan pemberian makan bayi dan anak usia 6-24 bulan. Bentuk kegiatan ini dengan memberikan penyuluhan dan membagikan leaflet kepada ibu hamil dan ibu yang memiliki bayi balita di posyandu melati Rejomulyo Lampung Selatan.Metode pada pengabdian masyarakat ini dengan ceramah, tanya jawab dan pembagian leaflet. Kegiatan berjalan dengan baik dan telah dilaksanakan pada tanggal 16 Januari 2024 di Posyandu Melati Rejomulyo Lampung Selatan. Jumlah peserta  sebanyak 70 orang. Peserta mendapatkan edukasi pentingnya persiapan menyusui dan pemberian makan bayi dan anak usia 6-24 bulan.Diharapkan kegiatan ini dapat bermanfaat dan dapat memotivasi ibu  dalam persiapan menyusui dan pemberian makan bayi dan anak usia 6-24 bulan, sehingga tumbuh kembang anak optimal.
Hubungan Pengetahuan Ibu dan Dukungan Keluarga dengan Pemilihan Penolong Persalinan di Wilayah Kerja Puskesmas Pajagan Kecamatan Sajira Kabupaten Lebak
Authors: Rahmadhena Melisa Putri , Handayani Dwi Rizka Shofiana
Published: May 2024

ABSTRACT The MMR in West Java Province in 2022 was recorded at 127/100,000 live births, while the National MMR reached 189/100,000 live births, while the IMR in Banten Province was 13.8 per 1000 live births.To determine the relationship between maternal knowledge and family support and the selection of birth attendants in the work area of the Pajagan Health Center, Lebak Regency in 2023. Use analyst by designcross sectional The research population was 225 respondents in the third trimester of pregnancy at the Pajaan Community Health Center. The research sample consisted of 54 respondents.bivariate analysis eusing testShapiro Wilk Test. Test resultsShapiro wilk Test earned value 0.000 (p>0.05). So it can be concluded that there is no relationship between maternal knowledge and family support and the selection of birth attendants in the work area of the Pajagan Public Health Center, Lebak Regency. The conclusion was that there was no relationship between maternal knowledge and family support and the selection of birth attendants in the work area of the Pajagan Community Health Center, Lebak Regency. Suggestions in this research are for educational institutions, for research sites, for respondents and for future researchers. Keywords: Third Trimester Pregnant Mother, Birth Assistant  ABSTRAK AKI di Provinsi Jawa Barat tahun 2022 tercatat sebanyak 127/100.000 kelahiran hidup, Sementara AKI Nasional mencapai 189/100.000 kelahiran hidup, sedangkan AKB di Provinsi Banten di angka 13,8 per 1000 kelahiran hidup.  Mengetahui hubungan antara pengetahuan ibu dan dukungan keluarga dengan pemilihan penolong persalinan di wilayah kerja puskesmas pajagan kabupaten lebak tahun 2023. Menggunakan analitik dengan desain cross sectional Populasi penelitian adalah ibu hamil trimester III di Puskesmas Pajaan sebanyak 225 responden. Sampel penelitian berjumlah 54 responden.  analis bivariat emenggunakan uji Shapiro Wilk Test. Hasil uji Shapiro wilk Test diperoleh nilai 0,000 (p>0,05). sehingga dapat disimpulkan tidak ada hubungan antara pengetahuan ibu dan dukungan keluarga dengan pemilihan penolong persalinan di wilayah kerja puskesmas pajagan kabupaten lebak. Simpulan didapatkan tidak ada hubungan antara pengetahuan ibu dan dukungan keluarga dengan pemilihan penolong persalinan di wilayah kerja puskesmas pajagan kabupaten lebak. Disaran dalam penelitian ini untuk Institusi pendidikan, untuk tempat penelitian, untuk responden dan untuk peneliti selanjutnya. Kata Kunci: Ibu Hamil Trimester III, Penolong Persalinan
Recycling Cost formation and Profitability of foods and beverages firm: Evidence from Flour Milling Industries of Nigeria Plc (1991-2021)
Authors: Madu Ikemefuna  , Idris Mohammed Gurin  , Madu Rejoice Ezinne
Published: May 2024

Recycling is one of the most viable options to reuse the end of the product in the closed-loop supply chains (CLSC) management. The major focus of this study is to examine the influence of product recycling cost on the profitability of food and beverage firms. This study relied solely on secondary data sourced which was subjected to a mathematical model using regression analysis. It was observed that dependent and the independent variables has a strong positive relationship with r=0.741. The coefficient of determination r2=0.549 shows that 54.9% of the variation in profit can be explained by production cost at 95% level of significant while in the flour mills Nigeria plc, the dependent and the independent variables has a weak positive relationship with r=0.363. The coefficient of determination r2=0.132 shows that 13.2% of the variation in profit can be explained by the production cost at 95% level of significant. Finally in Dangote Nigeria plc, dependent and the independent variables has a weak positive relationship with r=0.174. The coefficient of determination r2=0.030 Shows that 03.0% of the variation in profit can be explained by the production cost at 95% level of significant.
Albayrak Gazetesi’ne Göre Kars Ve Iğdır’da Türk Ermeni Savaşı (1919-1920)
Authors: Ercilsin Yasin
Published: May 2024

Kars ve Iğdır coğrafyası stratejik öneminden dolayı birçok milletin hâkimiyet mücadelesine sahne oldu. Bölgede en son yaşanan kanlı savaşlardan biri de Türk-Ermeni Savaşı idi. Osmanlı İmparatorluğu’nun yönetiminde üretken milletlerden biri olan Ermeniler, 19. yüzyılda milliyetçilik akımının da etkisi ile Kafkasya ve Anadolu’da hâkimiyet kurmak istediler. Fakat başarısız oldular. Emperyalizm destekli Ermenilerin Birinci Dünya Savaşı’ndaki isyanı kanlı bir şekilde neticelendi. Ermeni Hükümeti, 30 Ekim 1918’de imzalanan Mondros Mütarekesi’nin ardından Anadolu ve Kafkasya’da Müslüman katliamına yeniden başladı. Ermeni çetelerin yürüttüğü katliamdan en çok etkilenen bölgelerden biri de Kars ve Iğdır idi. Kazım Karabekir Paşa komutasındaki 15. Kolordu 28 Eylül 1920’de başlattığı askeri harekâtının neticesinde Kars ve Iğdır çevresinde Türk hâkimiyetini sağladı. Bu çalışmanın amacı Kars ve Iğdır coğrafyasındaki askeri ve siyasi olayların Albayrak gazetesine yansımalarını arşiv belgeleri ile birlikte incelemektir.
Kastamonu Şer’iyye Sicillerine Göre: Kastamonu Kazası’nda Aile (1750-1775)
Authors: Yazıcı Fatime
Published: May 2024

Bu çalışmada, XVIII. yüzyılın ikinci yarısında Kastamonu Kazası’nda aile müessesi ele alınmıştır. 1750-1775 yıllarını ihtiva eden araştırmada, Kastamonu şer’iyye sicilleri esas alınarak Kastamonu Kazası’nda ailenin işlevi, evlenme, nikâh, mehir, çok eşlilik (poligami), boşanma, nafaka, vasi, çocuk, çocuğun genel açıdan toplumsal niteliği, kadının sosyal hayattaki yeri ve önemi, ailede ekonomik durum gibi sosyo-iktisadî olgular incelenmiştir. Ayrıca bahsedilen bu unsurlar çerçevesinde her husus kendi başlığı altında irdelenerek konu hakkında detaylı bilgi verilmiştir. XVIII. yüzyılın çalkantılı siyasi hayatı içerisinde, Osmanlı Devleti’nde çok büyük bir ehemmiyet arz eden ve içtimaî yapının temelini oluşturan ailenin konumu, Kastamonu örneği üzerinden ve büyük oranda arşiv verilerinden hareketle yola çıkılıp, araştırma eserlerden de istifade edilerek ortaya konulmuştur.
Влияние концентрации пенообразователя на смачивающую способность и кратность пены при дозировании в автоматических спринклерных установках пожаротушения
Authors: Лихоманов Алексей Олегович , Навроцкий Олег Дмитриевич , Жуковский Сергей Александрович , Камлюк Андрей Николаевич
Published: May 2024

Цель. Определить зависимость смачивающей способности и кратности пены от концентрации пенообразователя (смачивателя) для тушения пожаров, а также установить концентрационные пределы пенообразователя, при которых огнетушащий раствор соответствует требованиям технических нормативных правовых актов и технической документации производителя по кратности пены и показателю смачивающей способности. На примере модельного помещения выполнить гидравлический расчет автоматической спринклерной установки пожаротушения и проанализировать возможность поддержания необходимой концентрации пенообразователя дозирующим устройством напорного типа с шайбой.
Методы. Общая методология работы предусматривала использование теоретических (анализ, синтез, сравнение) и экспериментальных методов исследования. Смачивающая способность пенообразующего раствора и кратность генерируемой пены определялись экспериментально с использованием метода испытаний, описанного в СТБ 2459-2016. Обработка экспериментальных данных выполнена с использованием статического регрессионного анализа, а также с установлением неопределенности измерений.
Результаты. По результатам экспериментальных исследований установлено, что концентрация пенообразователей (смачивателей) ОПС-0,4 более 0,67 % и СП-01 более 0,77 % в растворе может привести к повышению кратности пены, образующейся на выходе из оросителей автоматической спринклерной установки пожаротушения (УП), более 5 и, соответственно, ухудшению эффективности работы установки при тушении пожара. По этой причине в спринклерных УП дозирующее устройство должно обеспечивать некоторый минимальный (работа одного диктующего оросителя) и максимальный расход пенообразователя для поддержания достаточной для эффективного тушения концентрации. На примере модельного помещения размером 12,5×7,7 м показано, что при использовании дозирующего устройства напорного типа с шайбой, имеющей фиксированный диаметр отверстия для ввода пенообразователя в подводящий трубопровод УП, превышение рекомендуемой производителями концентрации пенообразователя марки СП-01 более чем в 7,7 раза происходит при вскрытии трех из двадцати четырех оросителей потолочной секции УП. На основании этого необходимо сделать вывод, что при проектировании спринклерных УП следует проводить детальный расчет дозирования пенообразователя при последовательном срабатывании оросителей в секции либо применять дозирующие устройства, способные в автоматическом режиме регулировать дозирование в зависимости от расхода воды в подводящем трубопроводе.
Область применения исследований. Проектирование автоматических установок пожаротушения с применением спринклерных оросителей.
3D-моделирование и исследование напряженного состояния современных конструкций резервуаров пожарных автоцистерн объемом 5 м3 из композитного материала и высоколегированной стали
Authors: Короткевич Сергей Геннадьевич , Ковтун Вадим Анатольевич , Ковалев Павел Викторович
Published: May 2024

Цель. Расчет напряженного состояния и запаса прочности современных конструкций резервуаров пожарных автоцистерн объемом 5 м3 из композитного материала и высоколегированной стали с учетом эксплуатационных нагрузок.
Методы. Разработка 3D-моделей конструкций цистерн выполнялась в программном комплексе SolidWorks. Создание их конечно-элементных моделей и расчет проводились в модуле Static Stractural программного комплекса ANSYS Workbench.
Результаты. Проведен анализ особенностей применения композитных материалов при современном производстве пожарных автоцистерн, представлены их преимущества по сравнению со стальными. Разработаны 3D-конечно-элементные модели конструкций цистерн объемом 5 м3 из усиленного армированного волокнистого стеклопластика и высоколегированной нержавеющей стали. Для проведения сравнительного расчета выбраны наиболее нагруженные режимы и условия, характеризующие особенности движения пожарных автомобилей к месту ликвидации чрезвычайных ситуаций. Расчет позволил установить зависимости, связывающие напряженное состояние конструкций цистерн с режимами движения пожарных автомобилей, а также выявить наиболее нагруженные узлы в конструкциях. Представлены результаты расчета запаса прочности конструкций цистерн с учетом эксплуатационных нагрузок.
Область применения исследований. Пожарные аварийно-спасательные подразделения, промышленные предприятия и высшие учебные заведения.
ADMINISTRATIVE AND LEGAL ASPECTS OF ENSURING FINANCIAL AND ECONOMIC SECURITY
Authors: OSTAPENKO LEONID , PANFILOVA TETIANA , SLYVKA MARIIA , KOHUT YAROSLAV , KOZYTS’KA GALYNA , BUNDZ ROSTYSLAV
Published: May 2024

The article proposes the methodological foundations of the modern concept of economic and financial security. It is argued that, in general, the assessment of the state of economic security is carried out on the basis of the characteristics of external and internal threats, interpreted as a complex of various types of factors that create a real danger to vital national economic interests. It is specified that threats to economic security are a consequence of developing contradictions both in the internal economic space of the nation-state and beyond its borders. Particular attention is paid to the analysis of the role of FinTech in shaping the financial security landscape.
RESILIENCE OF UKRAINIANS AS A FACTOR OF NATIONAL SECURITY IN WAR CONDITIONS
Authors: SULYATYTSKYY IVAN , MATEYUK OLEG , MELNYK ANTONII , SALAMON OLEH , DROBIT LILIYA
Published: May 2024

Vectors for the study of human resiliency can be found in concepts of the life path, in models of the life world, in works devoted to the study of a person’s resistance to stress, his personal and meaningful life potentials, existential and personal crises. The paper traces evolution of resiliency concept and considers phenomenon of resiliency during war conflicts based on the example of current war in Ukraine.
INNOVATION DEFENSE CLUSTERS - AN EFFECTIVE DRIVER OF DEFENSE AND NATIONAL SECURITY OF UKRAINE
Authors: FERDMAN HENNADII , FILIPPOVA VIKTORIIA , KOZAK IVAN , PASICHNYI ROMAN , LUTSYSHYN ANDRII , AKIMOV OLEKSANDR
Published: May 2024

Today, Ukraine finds itself at a stage where there is an understanding that we significantly lag behind leaders in terms of technological and innovative solutions. There is recognition that the existing innovation system is outdated, failing to foster genius or facilitate a formal process for generating new ideas. Even if it does foster innovation, it fails to provide adequate work and compensation, leading to a brain drain of talented youth and experienced professionals abroad. As is well known, any war serves as a driving force for progress; it was during periods of war that numerous ingenious modernizations, design decisions, and inventions were made. However, despite the aggression of the Russian Federation, in Ukraine, the innovation landscape, including the defense innovation system, operates with significant slowdown, encountering barriers leading to minimal efficiency, and fails to address both the acceleration of economic development and the provision of national security for the state. After a brief analysis of the experience of leading countries around the world in utilizing innovations, an assessment of Ukraine’s innovative policies is presented. Key recommendations are provided regarding the establishment of innovative clusters for defense tailored to the specific branches of the Armed Forces of Ukraine. These clusters are designed to serve both the defense needs of the state and the broader national security interests of Ukraine.
PUBLIC SCULPTURE IN WARTIME UKRAINE AS A FORM OF THE STATE’S MEMORY POLITICS
Authors: ISYCHENKO IGOR , PROTAS MARYNA , MIRONOVA TATIANA , BOKOTEI MYKHAILO , BULAVINA NATALIIA
Published: May 2024

The authors argue that during wartime in Ukraine, public sculpture serves as a reflection of the memory politics of the contemporary Ukrainian state. As such, these politics are aimed at breaking away from the Soviet legacy that continues to exist simultaneously in the form of hidden or sometimes obvious remnants of older colonial narratives of Ukrainian history and in the form of aesthetic artifacts akin to those that can be seen in the public space of big cities, e.g. sculptures and reliefs, etc. However, in its efforts to shed the Soviet legacy, Ukraine's memory politics often uncritically adopt dominant capitalist narratives, inadvertently perpetuating another form of cultural oppression and colonization. In addition to critiquing contemporary market-driven discourse, the authors stress the importance of not overlooking the layer of mythological memory, as it constitutes one of the most fundamental elements of Europe's cultural landscape.
Enhancing Design Ability Through Experiential Learning in Textile Design Education
Authors: Xue Wenliang
Published: May 2024

The major of textile design at Donghua University is a double bachelor’s degrees program that was supported by Shanghai Academic Degrees Committee, integrating the discipline of design and textile engineering. This study presented a series of practical courses in four semesters from the sophomore year to senior year, to help undergraduate textile design students enhance their product design skills and abilities through experiential learning. The practical curriculum design, implementation process and learning outcomes are introduced in the paper. Results in the study not only reveal the method to embed experiential learning theory into practical courses, but also indicate the importance of learning-by-doing philosophy in higher-education.
The Impact of Instructional Effectiveness on Soft Skills Development among College Students: Mediating and Moderating Mechanisms
Authors: Cavender RayeCarol
Published: May 2024

Despite growing demand by employers across industries to hire employees with soft skills, a soft skill mismatch exists between skill sets that companies are seeking and those possessed by top talent. Thus, collegiate academic programs must equip students with both discipline-based knowledge and the necessary soft skills to meet industry needs and achieve success in their careers. This study investigates instructors’ role in facilitating college students’ soft skill development using two theoretical foundations. The five-scale survey instrument was refined through expert review and then disseminated at a U.S. university. The 410 respondents were students from all class levels and a range of disciplines. We used nonparametric bootstrap analysis to examine underlying mechanism of the relationship between instructional effectiveness and students’ soft skill development, through the mediating effects of career self-efficacy and career motivation, as well as the moderating role of students’ attitude toward higher education. Results and findings are discussed.
Circulation
Authors: Wadiwel Dinesh Joseph
Published: May 2024

This Chapter examines the case study of the globalised transfer of animals as living assets in the form of live animal transport. This is an example of circulation where animals are moved from one production phase to another within a value chain. Tracing the unique character of the movements of live animals, this Chapter looks at the way this circulation alters with the advent of mechanisation, in concert with attempts to make more efficient the application of human labour. However, recognition of animal labour power significantly alters how we see this circulation. Firstly, animals are required to labour if they are moved live: they must complete a metabolic labour on themselves in order to preserve the value in the raw material of their own bodies. Secondly, against a view that would see circulation as a disruption to production, the reality of animal labour makes this time “productive.” This means, for example, that producers can rely on the fact that animals can be shipped as raw materials and arrive, miraculously, as a “finished product” which is ready for slaughter.
On Being a Vegetarian in Texas: The Incongruities and Politics of Linklater’s Fast Food Nation
Authors: Parkinson Claire
Published: May 2024

A fictional adaptation of the best-selling non-fiction book of the same name written by journalist Eric Schlosser, Fast Food Nation (2006) divided critics and has been widely considered as one of director Richard Linklater’s less successful films.
Thematically, the film chimes with Linklater’s personal commitment to vegetarianism, animal rights and workers’ rights, political perspectives which are, by the director’s own admission, at odds with his Texan identity. This chapter discusses Richard Linklater through the incongruities and politics of Fast Food Nation. It argues that the film and the director harbor iconoclastic and commercial sensibilities and explores how these seemingly conflicting spheres are reconciled, or not, through Linklater’s political beliefs.
La identificación primaria y su relación con el comportamiento agresivo
Authors:   Universidad Internacional SEK, Altamirano López Lorena Fernanda , Cobo Álvarez Miguel Alejandro ,   Universidad Internacional SEK, Saltos Salazar Lenin Fabián ,   Universidad Católica de Santiago de Guayaquil
Published: May 2024

La Identificación primaria como fuente formadora de la estructura yoica constituye un tema de gran interés para la comunidad psicoanalítica y de gran revisión bibliográfica, no obstante, el proyecto a estudiarse en Ecuador es amplio. Por lo tanto, este estudio tuvo como objetivo analizar la relación entre la Identificación Primaria y el comportamiento Agresivo en 50 estudiantes de entre 14 y 17 años de la Unidad Educativa “Rumiñahui”. Para ello, se aplicaron el Test proyectivo Casa-Árbol-Persona de Buck y el Cuestionario de Agresividad de Buss y Perry. Los resultados obtenidos con estos instrumentos se usaron en un análisis de correlación, el cual mostro resultados significativos entre los niveles de Ansiedad medidos con el HTP y la presencia de conductas Hostiles en el test de agresividad. Sin embargo, no hubo resultados concluyentes sobre la relación entre otros aspectos de la Identificación Primaria y tipos de Agresividad. Los datos aportan información preliminar sobre la temática, aunque se requiere profundizar la investigación con metodologías más rigurosas para establecer hallazgos más sólidos.
El derecho de los trabajadores a la desconexión digital en la legislación laboral ecuatoriana
Authors:   Universidad Indoamérica, Molina Rubio Wilson Hernán , Silva Barrera Esthela Paulina ,   Universidad Indoamérica
Published: May 2024

El presente estudio examina la desconexión laboral en Ecuador, con un enfoque en el impacto de la tecnología en la integración de la vida laboral y personal, específicamente en el contexto del teletrabajo. Se subraya la importancia de una regulación adecuada para garantizar el derecho a la desconexión digital. El análisis evalúa las medidas normativas actuales, incluyendo la reforma al Código del Trabajo en Ecuador. Para llevar a cabo esta investigación, se realizó una revisión bibliográfica que se basó en una exhaustiva recopilación de fuentes entre 2021 y 2023, abarcando leyes, jurisprudencia y artículos académicos, con un enfoque particular en la legislación laboral ecuatoriana y normativas internacionales, excluyendo fuentes no pertinentes o no reconocidas. En los resultados y conclusiones de este estudio, se aborda la evolución del derecho de los trabajadores a la desconexión digital. Las tecnologías de la información han difuminado las fronteras entre la vida laboral y personal, destacándose la adaptación de la legislación laboral ecuatoriana a estos cambios, con especial atención en el teletrabajo. La investigación resalta cómo la tecnología ha eliminado las fronteras entre el trabajo y la vida personal, especialmente en el ámbito del teletrabajo, subrayando la necesidad de regular la desconexión digital. A pesar de la incorporación de esta normativa en la legislación ecuatoriana, se enfrenta a desafíos en su implementación.
The gut microbial composition in polycystic ovary syndrome with hyperandrogenemia and its association with steroid hormones
Authors: Li Miao , Chang Qiurong , Luo Ye , Pan Jiaping , Hu Ye , Liu Binya , Ma Mengmeng , Wang Qiaoling , Guo Yi , Wang Qian
Published: May 2024

Background: Polycystic ovary syndrome (PCOS) is characterized by excess androgens, ovulatory dysfunction, and polycystic ovaries. The mechanisms underlying ovulatory and metabolic disorders in PCOS remain elusive, hampering therapeutic development. Enhanced metabolic health correlates with increased microbiota gene content and microbial diversity. We aimed to explore the impact of gut microbiota and serum steroids on PCOS regulation associated with androgen excess.

Methods: The fecal samples of patients with hyperandrogenic PCOS (n = 14) and control group with PCOS (n = 14) were analyzed by 16S rRNA gene sequencing. The peripheral venous blood of all subjects was collected to detect serum hormones. The association between gut microbiota and serum hormones was analyzed with the R language.

Results: Our findings reveal that the hyperandrogenic PCOS group exhibits lower richness and diversity of gut microbiota compared to the control group. Characteristic genera in PCOS patients with hyperandrogenism include Bifidobacterium, Enterobacteriaceae_unclassified, Streptococcus, Saccharimonadaceae, Enterococcus, and Eubacterium_nodatum_group. Five hormones, including 5β-androsterone, deoxycorticosterone, corticosterone, 11-dehydrocorticosterone, and cortexolone, emerge as potential serum biomarkers for identifying patients with hyperandrogenic-PCOS (HA-PCOS). Furthermore, a lower vitamin D3 level may act as a susceptibility factor, suggesting that vitamin D3 supplementation could serve as a potential intervention for PCOS with hyperandrogenism.

Conclusion: Specific fecal microbiota and serum steroids may be used as characteristic markers for clinical diagnosis of hyperandrogenic-PCOS. This research enhances our understanding of the intricate interplay among hormones, gut microbiota, and hyperandrogenemia in patients with PCOS.
FIT2 proteins and lipid droplet emergence, an interplay between phospholipid synthesis, surface tension, and membrane curvature
Authors: Graff Juliette , Schneiter Roger
Published: May 2024

Lipid droplets (LDs) serve as intracellular compartments primarily dedicated to the storage of metabolic energy in the form of neutral lipids. The processes that regulate and control LD biogenesis are being studied extensively and are gaining significance due to their implications in major metabolic disorders, including type 2 diabetes and obesity. A protein of particular interest is Fat storage-Inducing Transmembrane 2 (FIT2), which affects the emergence step of LD biogenesis. Instead of properly emerging towards the cytosol, LDs in FIT2-deficient cells remain embedded within the membrane of the endoplasmic reticulum (ER). In vitro studies revealed the ability of FIT2 to bind both di- and triacylglycerol (DAG/TAG), key players in lipid storage, and its activity to cleave acyl-CoA. However, the translation of these in vitro functions to the observed embedding of LDs in FIT2 deficient cells remains to be established. To understand the role of FIT2 in vivo, we discuss the parameters that affect LD emergence. Our focus centers on the role that membrane curvature and surface tension play in LD emergence, as well as the impact that the lipid composition exerts on these key parameters. In addition, we discuss hypotheses on how FIT2 could function locally to modulate lipids at sites of LD emergence.
Recent progress in thiocarbazone metal complexes for cancer therapy via mitochondrial signalling pathway
Authors: Zheng Yunyun , An Hangyi , Qi Jinxu , Li Jiaming
Published: May 2024

Mitochondria are the energy factories of cells and are important targets for the development of novel tumour treatment strategies owing to their involvement in processes such as apoptosis, oxidative stress, and metabolic programming. Thiosemicarbazone metal complexes target mitochondria and reduce mitochondrial membrane potential. The breakdown of mitochondrial membrane potential is a key event in the early stage of apoptosis, which releases cytochrome C and other pro-apoptotic factors, activates the intracellular apoptotic enzyme cascade, and eventually causes irreversible apoptosis of tumour cells. Thiosemicarbazone metal complexes targeting the mitochondria have recently emerged as potential antitumour agents; therefore, this review describes the structural diversity of thiosemicarbazone metal [Fe(III), Cu(II), Ni(II), Zn(II), Ga(III), Pb(II), Au(III), and Ir(III)] complexes and explores their anti-tumour mechanisms that target mitochondrial pathways.
A rare case of successful treatment of peritoneal dialysis patient with Serratia marcescens peritonitis without catheter removal: case report and literature review
Authors: Xie Ruizhi , Ling Ying , Huang Yaru , Qin Lulu , Bao Kun , Qin Xindong
Published: May 2024

Serratia marcescens, as a Gram-negative opportunistic pathogen, is a rare cause of peritonitis and has worse clinical outcomes than Gram-positive peritonitis. In this case report, we describe a case of Serratia marcescens associated peritonitis that was successfully cured without catheter removal. A 40-year-old male patient with peritoneal dialysis who worked in the catering industry was admitted to the hospital for 16 hours after the discovery of cloudy peritoneal dialysate and abdominal pain. Ceftazidime and cefazolin sodium were immediately given intravenously as an empirical antibiotic regimen. After detecting Serratia marcescens in the peritoneal diasate culture, the treatment was switched to ceftazidime and levofloxacin. The routine examination of peritoneal dialysate showed a significant decrease in white blood cells, the peritoneal dialysate became clear, and the peritoneal dialysis catheter was retained. The patient was treated for 2 weeks and treated with oral antibiotics for 1 week. It is necessary to further strengthen the hygiene of work environment to prevent Serratia marcescens infection in peritoneal dialysis patients. We recommend that patients with Serratia marcescens associated peritonitis should be treated with a combination of antibiotics as early as possible empirically, and at the same time, the peritoneal dialysis fluid culture should be improved, and the antibiotic regimen should be timely adjusted according to the drug sensitivity results. For patients with clinical symptoms for more than 3 days, considering the strong virulence of Serratia marcescens, whether to use meropenem directly or not can provide a reference for clinical decision-making. Further clinical studies are needed to achieve more precise anti-infective treatment.
Object surface roughness/texture recognition using machine vision enables for human-machine haptic interaction
Authors: Lin Zixuan , Zheng Haowei , Lu Yue , Zhang Jiaji , Chai Guohong , Zuo Guokun
Published: May 2024

Tactile feedback can effectively improve the controllability of an interactive intelligent robot, and enable users to distinguish the sizes/shapes/compliance of grasped objects. However, it is difficult to recognize object roughness/textures through tactile feedback due to the surface features cannot be acquired with equipped sensors. The purpose of this study is to investigate whether different object roughness/textures can be classified using machine vision and utilized for human-machine haptic interaction. Based on practical application, two classes of specialized datasets, the roughness dataset consisted of different spacing/shapes/height distributions of the surface bulges and the texture dataset included eight types of representative surface textures, were separately established to train the respective classification models. Four kinds of typical deep learning models (YOLOv5l, SSD300, ResNet18, ResNet34) were employed to verify the identification accuracies of surface features corresponding to different roughness/textures. The human fingers' ability to objects roughness recognition also was quantified through a psychophysical experiment with 3D-printed test objects, as a reference benchmark. The computation results showed that the average roughness recognition accuracies based on SSD300, ResNet18, ResNet34 were higher than 95%, which were superior to those of the human fingers (94% and 91% for 2 and 3 levels of object roughness, respectively). The texture recognition accuracies with all models were higher than 84%. Outcomes indicate that object roughness/textures can be effectively classified using machine vision and exploited for human-machine haptic interaction, providing the feasibility of functional sensory restoration of intelligent robots equipped with visual capture and tactile stimulation devices.
To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics
Authors: Wang Lin , Li Tie , Cao Wen-Xuan , Zhao Jin-Ying , Xu Xiao-Hong , Chai Jia-Peng , Zhang Jia-Xun , Liu Jia , Wang Fu-Chun
Published: May 2024

Graphene-based warm uterus acupoint paste (GWUAP) is an emerging non-drug alternative therapy for the treatment of primary dysmenorrhea (PD), but the underlying mechanism is still unclear. SD female rats were randomly divided into control group, model group and treatment group to explore the mechanism of GWUAP in the treatment of PD. Combined with 16S rDNA and fecal metabolomics, the diversity of microbiota and metabolites in each group was comprehensively evaluated. In this study, GWUAP reduced the torsion score of PD model rats, improved the pathological morphology of uterine tissue, reduced the pathological damage score of uterine tissue, and reversed the expression levels of inflammatory factors, pain factors and sex hormones. The 16 S rDNA sequencing of fecal samples showed that the abundance of Lactobacillus in the intestinal flora of the model group decreased and the abundance of Romboutsia increased, while the abundance of Lactobacillus in the intestinal flora of the treatment group increased and the abundance of Romboutsia decreased, which improved the imbalance of flora diversity in PD rats. In addition, 32 metabolites related to therapeutic effects were identified by metabolomics of fecal samples. Moreover, there is a close correlation between fecal microbiota and metabolites. Therefore, the mechanism of GWUAP in the treatment of PD remains to be further studied.
The open ontology and information society
Authors: Naidoo Meshandren
Published: May 2024

Information, as the most elusive subject, is central to all forms of thought, governance, economic structure, science, and society. Regulation of information, especially within the healthcare field, is proving to be a difficult task globally, given the lack of a qualitative framework and understanding of the concept and properties of information (or data) itself. The presentation of the overall qualitative framework, comprising a qualitative analysis of information, data, and knowledge, will be valuable and of great assistance in delineating regulatory, ethical, and strategic trajectories. In addition, this framework provides insights (and answers) regarding (1) data privacy and protection; (2) delineations between information, data, and knowledge based on the important notion of trust; (3) a structured approach to establishing the necessary conditions for an open society and system, and the maintenance of said openness, based on the work of Karl Popper and Georg Wilhelm Friedrich Hegel; (4) an active agent approach that promotes autonomy and freedom and protects the open society; and (5) a data governance mechanism based on the work of Friedrich Hayek, which structures the current legal–ethical–financial and social society. This is insightful for questions relating to the extent of rights and duties, the extent of biological bodies and freedom, and the structure of relations in distributed networked systems. There is great value offered in this framework; furthermore, it provides critical insights and thoughts about (and uncovers the interplay between) academic culture, politics, science, society, and societal decay. Note that, in line with the ideas expressed in this manuscript, such as incorporation of personal experience (thereby mending the Kantian and Cartesian gap), a first-person perspective will be used, where relevant.
Patients with juvenile idiopathic arthritis have decreased clonal diversity in the CD8+ T cell repertoire response to influenza vaccination
Authors: Sabbagh Sara E. , Haribhai Dipica , Gershan Jill A. , Verbsky James , Nocton James , Yassai Maryam , Naumova Elena N. , Hammelev Erin , Dasgupta Mahua , Yan Ke , Gorski Jack , Williams Calvin B.
Published: May 2024

Recurrent exposures to a pathogenic antigen remodel the CD8+ T cell compartment and generate a functional memory repertoire that is polyclonal and complex. At the clonotype level, the response to the conserved influenza antigen, M158–66 has been well characterized in healthy individuals, but not in patients receiving immunosuppressive therapy or with aberrant immunity, such as those with juvenile idiopathic arthritis (JIA). Here we show that patients with JIA have a reduced number of M158–66 specific RS/RA clonotypes, indicating decreased clonal richness and, as a result, have lower repertoire diversity. By using a rank-frequency approach to analyze the distribution of the repertoire, we found several characteristics of the JIA T cell repertoire to be akin to repertoires seen in healthy adults, including an amplified RS/RA-specific antigen response, representing greater clonal unevenness. Unlike mature repertoires, however, there is more fluctuation in clonotype distribution, less clonotype stability, and more variable IFNy response of the M158–66 specific RS/RA clonotypes in JIA. This indicates that functional clonal expansion is altered in patients with JIA on immunosuppressive therapies. We propose that the response to the influenza M158–66 epitope described here is a general phenomenon for JIA patients receiving immunosuppressive therapy, and that the changes in clonal richness and unevenness indicate a retarded and uneven generation of a mature immune response.
Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody
Authors: Olia Adam S. , Prabhakaran Madhu , Harris Darcy R. , Cheung Crystal Sao-Fong , Gillespie Rebecca A. , Gorman Jason , Hoover Abigayle , Morano Nicholas C. , Ourahmane Amine , Srikanth Abhinaya , Wang Shuishu , Wu Weiwei , Zhou Tongqing , Andrews Sarah F. , Kanekiyo Masaru , Shapiro Lawrence , McDermott Adrian B. , Kwong Peter D.
Published: May 2024

The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort human leukocytes, and isolate a new VH6-1-class member, antibody L5A7, which potently neutralized diverse group 1 and group 2 influenza A strains. While its heavy chain derived from the canonical IGHV6-1 heavy chain gene used by the class, L5A7 utilized a light chain gene, IGKV1-9, which had not been previously observed in other VH6-1-class antibodies. The cryo-EM structure of L5A7 in complex with Indonesia 2005 hemagglutinin revealed a nearly identical binding mode to other VH6-1-class members. The structure of L5A7 bound to the isolating anti-idiotype antibody, 28H6E11, revealed a shared surface for binding anti-idiotype and hemagglutinin that included two critical L5A7 regions: an FG motif in the third heavy chain-complementary determining region (CDR H3) and the CDR L1 loop. Surprisingly, the chemistries of L5A7 interactions with hemagglutinin and with anti-idiotype were substantially different. Overall, we demonstrate anti-idiotype-based isolation of a broad and potent influenza A virus-neutralizing antibody, revealing that anti-idiotypic selection of antibodies can involve features other than chemical mimicry of the target antigen.
High-strength and high-elasticity silk fibroin-composite gelatin biomaterial hydrogels for rabbit knee cartilage regeneration
Authors: Ma Hebin , Xie Bowen , Chen Hongguang , Song Puzhen , Zhou Yuanbo , Jia Haigang , Liu Jing , Zhao Yantao , Zhang Yadong
Published: May 2024

Suitable hydrogel materials for cartilage tissue repair should exhibit high strength and toughness, and excellent biocompatibility. However, the mechanical properties of most hydrogels cannot meet the complex mechanical requirements of articular cartilage tissues. Given this situation, we have adopted a chemical cross-linking method using hexafluoro isopropanol to mediate the cross-linking of Silk Fibroin (SF) and deionized water (DI), which promoted the formation of β-sheets, generating “high-toughness” Silk Fibroin hydrogels. The introduction of Gelatin (Gel) served to increase the content of β-sheets and increase the tensile modulus from 24.51 ± 2.07 MPa to 39.75 ± 6.54 MPa, which significantly enhanced the flexibility of the hydrogel and meets the mechanical requirements of cartilage tissue. In addition, in vitro biological experiments have shown that the introduction of Gel promotes cell proliferation and enhances the production of cartilage extracellular matrix by chondrocytes. In vivo experiments have demonstrated that SF/Gel hydrogel promotes articular cartilage regeneration more effectively than SF hydrogel, as evidenced by improvements in gross appearance, imaging, and histology. This study has established that high-strength SF/Gel hydrogel prepared by applying the binary-solvent-induced conformation transition strategy has potential applications in cartilage tissue repair and regeneration and is a feasible biomaterial for osteochondral regeneration.