bluuebunny/crossref_metadata_2025 huggingface dataset:
Theileria infection in bullfighting cattle in Thailand
Authors: Rakwong Pirayu , Keawchana Narissara , Ngasaman Ruttayaporn , Kamyingkird Ketsarin
Published: December 2022

Background and Aim: An apicomplexan protozoan parasite, namely, Theileria, primarily causes theileriosis in cattle worldwide. The virulence of the disease has been neglected because of it's low pathogenicity. However, the disease can have a substantial effect, depending on the virulence of the species, low host immunity, and coinfection. In Thailand, the molecular detection of Theileria infection in bullfighting cattle and its hematological alterations have not been reported. Thus, this study aimed to identify Theileria species in bullfighting cattle in Thailand.

Materials and Methods: Blood samples were collected from bullfighting cattle presented at the Prince of Songkla University Animal Hospital and were determined on the basis of hematological evaluation and DNA extraction. Molecular detection using the 18s rRNA and merozoite surface antigen genes was conducted for Theileria spp. and Theileria orientalis, respectively. In addition, bidirectional sequencing of the positive samples was performed. Hematological alterations between Theileria infected and uninfected groups were statistically evaluated.

Results: The levels of Theileria spp. and T. orientalis infection in bullfighting cattle were 44.62% (58/130) and 41.54% (54/130), respectively. Theileria orientalis, Theileria sinensis, and Theileria spp. infections were identified in bullfighting cattle samples. Hematological evaluation indicated that the red blood cell (RBC) level was significantly lower in Theileria-infected cattle.

Conclusion: This study was the first to use molecular techniques in the identification of Theileria infection in bullfighting cattle in Thailand, with nearly one-half of the study population infected. Theileria infection in bullfighting cattle altered the RBC level, resulting in anemia. Therefore, tick control measures should be promoted.
Anti-tyrosinase Activities of Curcumin-Chitosan Gold
Nanoparticles Synthesized from Beetle (Oryctes rhinoceros)
Authors: Zainol Abidin N. Alyani , Kormin F. , Zainol Abidin N. Akhma , Abu Bakar M.F. , Iwansyah Ade Chandra
Published: December 2022

A breakthrough in cosmeceuticals by utilizing insects as major ingredients in cosmetic products is
gaining popularity. Therefore, the interest in rare sources of ingredients, for instance, from the Oryctes
rhinoceros beetle, can bring huge benefit in turning pest to wealth. In this study, curcumin was chosen
as the active ingredient loaded into chitosan-gold nanoparticles (CCG-NPs). However, curcumin is
unstable, has poor absorption, a high rate of metabolism and high sensitivity to light. These are all
factors that contribute to the lower bioavailability of any substance to reach the target cells. Therefore,
chitosan extracted from O. rhinoceros acts as a drug carrier and incorported in gold nanoparticles are
used to overcome these problems. The CCG-NPs were successfully synthesized at 70 ºC for 60 min
under optimal conditions of reactant ratio of 2:0.5 (0.5 mM HAuCl4:0.1% curcumin). The tyrosinase
enzyme inhibition of CCG-NPs from O. rhinoceros was 66.385 ± 3.0%. Thus showing a good inhibition
trait for the anti-tyrosinase assay as it is almost double the tyrosinase inhibition percentage when
being compared to CCG-NPs from the commercial chitosan. Therefore, CCG-NPs from O. rhinoceros
has a high potential in cosmeceutical applications as whitening agent.
Synthesis, Characterization and Molecular Docking Studies of Novel Mannich
Bases of Indole Analogs as Potent Antibacterial and Anticancer Agents
Authors: Padmaja V. , Sumakanth M. , Shashikala P.
Published: December 2022

A series of a novel indole analogs (5-substituted-1-methyl/ethyl-3-((5-methyl-1-(morpholino/
piperazinmethyl)-1H-pyrazol-3-yl)-imino)indolin-2-one (5a-l) were synthesized via Schiff base and
Mannich base mechanism. The structures of synthesized compounds were confirmed by IR, 1H NMR
and mass spectral data. The antibacterial activity by was measured by agar diffusion method. Some of
the analogs (5b, 5c, 5h, 5i and 5j) showed excellent antibacterial recreation against Staphylococcus
aureus, Bacillus subtilis and Escherichia coli, Salmonella paratyphi, Pseudomonas and compounds
5f, 5g, 5i showed good activity against MCF-7 cell line through MTT assay method. The molecular
docking studies of novel indole analogs revealed that compound 5i suggests perfect dock rating of
-5.826 with glide binding strength of -38.76 Kcal/mol. Dock results of all the compounds were ranged
from -5.826 (compound 5i) to -2.792 (compound 5d).
Hydrothermal Synthesis of Copper-Decorated Titanium Dioxide
Spherulites and their Photocatalytic Activity against Reactive Dyes
Authors: Sendil G.K. , Soundarrajan E. , Ranjitha M. Roselin , Klaivani R.A. , Raghu S.
Published: December 2022

The untreated discharge of industrial dyes into water supplies is a likely occurrence that can cause a
number of dangerous scenarios that are hazardous for the ecology. Herein, a simple hydrothermal
strategy for synthesizing copper-doped titanium dioxide nanoparticles (Cu-TiO2) were presented and
investigated its ability to photocatalytically degrade dyes e.g. reactive black 5 (RB5), red 198 (RR198)
and yellow 145 dyes (RY145). Firstly, the as-synthesized Cu-TiO2 nanoparticles were characterized
using powder X-ray diffraction (PXRD), UV-diffuse reflectance spectroscopy (UV-DRS), high
resolution-scanning electron microscopy (HR-SEM) and transmission electron microscopy (TEM)
techniques. Furthermore, the photocatalysis experiments were conducted using three reactive dye
solutions at different concentrations, pH, duration, etc. The spherulitic Cu-TiO2 photocatalyst exhibited
superior catalytic activity against the dyes and was able to achieve 82, 88 and 90% efficiencies for
RB5, RR198 and RY145 dyes, respectively. The kinetics and the reusability parameters were also
elaborated with respect to the obtained results. Therefore, Cu-TiO2 spherulites are professed to be
effectual photocatalyst materials for industrial scale dye degradation.
Kinetic and Thermodynamic Analysis of Pyrolysis of Coconut Wood Residue
Authors: Nangarthody Sindhu , Sivasubramanian V.
Published: December 2022

Physico-chemical properties, kinetics and thermodynamic analysis of biomass are important in
designing an efficient pyrolysis process. The current study aims to investigate the physico-chemical
behaviour, calorific value and kinetics of thermal decomposition of coconut wood (Cocos nucifera) at
10, 15, and 25 ºC/min using the thermogravimetric analysis (TGA) technique in nitrogen atmospheres.
Kinetic parameters were estimated using the Kissinger-Akahira-Sunose (KAS), Flynn-Wall-Ozawa
(FWO), Staring, Tang, Friedman and Coats-Redfern (CR) methods. Average activation energy estimated
from Kissinger-Akahira-Sunose (KAS), Starink, Tang and Coats-Redfern (CR) methods was ≈ 100
kJ/mol. The Flynn-Wall-Ozawa (FWO) method predicted a higher value of 104 kJ/mol and Friedman a
lower value of 81 kJ/mol. Thermodynamic parameters like change in enthalpy, Gibbs free energy and
entropy have also been evaluated.
A Facile Synthesis of Thiazole Derivatives bearing
Imidazole Moiety, Schiff Bases and their O-Glucosides
Authors: Dekate Shital M. , Hatzade Kishor M. , Ghatole Ajay M.
Published: December 2022

A unique approach for the synthesis of new thiazole O-glycosides is presented in this work.
2-Amino-4-hydroxy-phenyl-1,3-thiazole-5-carboxaldehyde (3a) was reacted with phenyl glyoxal and
benzil to form 4-(4-hydroxy-phenyl)-5-(4-phenyl-1H-imidazol-2-yl)-thiazol-2-amine (4a) and
4-(4-hydroxy-phenyl)-5-(4,5-diphenyl-1H-imidazol-2-yl)-thiazol-2-amine (4b), respectively. A series
of substituted Schiff bases of 4a and 4b were synthesized reacting with various aryl aldehyde to form
2-(imino substituted benzal)-4-(4-hydroxy-phenyl)-5-(4-phenyl-1H-imidazol-2-yl)-thiazoles (5a-e) and
2-(imino substituted benzal)-4-(4-hydroxy-phenyl)-5-(4,5-diphenyl-1H-imidazol-2-yl)-thiazoles (5f-j).
Glucosylation of compounds (5a-j) have been done by using acetobromoglucose as glucosyl donor to
afford 2-(imino substituted benzal)-4-(2,3,4,6-tetra-O-acetyl-p-O-β-D-glucosidoxyphenyl)-5-(4-phenyl-
1H-imidazol-2-yl)-thiazoles (6a-e) and 2-(imino substituted benzal)-4-(2,3,4,6-tetra-O-acetyl-p-O-β-
D-glucosidoxyphenyl)-5-(4,5-diphenyl-1H-imidazol-2-yl)-thiazoles (6f-j) further on deacetylation to
produce 2-(imino substituted benzal)-4-(p-O-β-D-glucosidoxyphenyl)-5-(4-phenyl-1H-imidazol-2-yl)-
thiazoles and 2-(imino substituted benzal)-4-(p-O-β-D-glucosidoxyphenyl)-5-(4,5-diphenyl-1Himidazole-
2-yl)-thiazoles (7f-j). The synthesized compounds were characterized by elemental analyses,
FTIR, 1H & 13C NMR and electron mass spectra (EI-MS) techniques and then screened for their in
vitro antimicrobial activity.
Effect of Zr-Nanofiller on Structural and Thermal Properties of
PVDF-co-HFP Porous Polymer Electrolyte Membranes Doped with Mg2+ Ions
Authors: Kundana N. , Venkatapathy M. , Neeraja V. , Espenti Chandra Sekhar , Jeedi Venkata Ramana , Reddy V. Madhusudhana
Published: December 2022

New poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-co-HFP)/ZrO2-based nanocomposite
porous polymer membranes were prepared with doping of magnesium ions using THF as solvent.
These membranes were prepared using the solvent casting technique. The optimal nanofiller (0, 2, 4,
6, 8 and 10% Zr nanopowder) was incorporated into the PVDF-co-HFP/MgTf3/ZrO2 and the
incorporation of the nanofiller results in an increase in the porosity of the prepared membranes. The
structural, morphological and thermal properties of the nanocomposite porous polymer membranes
were also investigated. The structural investigation and the identification of functional groups were
accomplished using FTIR technique. X-ray diffraction (XRD) analysis was performed to ascertain the
phase of polymer membranes and the phase change that happens upon interaction with nanofiller and
Mg2+ ions. Assessment of the nanocomposite porous polymer membrane's morphology and porous
structure was performed using a scanning electron microscope (SEM). DSC analysis was used to
evaluate the thermal behaviour of the nanocomposite porous membranes. The electrical and dielectric
studies confirmed the structural reformation of the polymer electrolyte materials. It was found that 8%
nanofiller is the best conducting composition for maximum ionic conductivity, dielectric constant and
Mg2+ ion mobility. The incorporation of ZrO2 nanofiller predominantly increases the number of free
ions and mobility of the charge carriers in the composite polymer electrolyte systems.
Diagnosing Mild Forms of Anorectal Malformation With Anorectal Manometry: A Prospective Study
Authors: den Hollander Venla E.C. , Gerritsen Steffie , van Dijk Tonnis H. , Trzpis Monika , Broens Paul M.A.
Published: December 2022

INTRODUCTION:

Rectoperineal congenital anorectal malformations (CARMs) are diagnosed by examining the perineum, combined with electric stimulation (ES) of the anal sphincter performed under anesthesia. This procedure may be troublesome because it is based on the observed contractibility of the sphincter. We aimed to add 3-dimensional high-resolution anorectal manometry (3D-HRAM) to the procedure and to assess its value for diagnosing rectoperineal forms of CARM.

METHODS:

We prospectively included 66 patients younger than 24 months who presented with constipation and were suspected of CARM, idiopathic constipation, or Hirschsprung disease. The patients were assessed between 2015 and 2021 at University Medical Center Groningen, the Netherlands. All patients underwent 3D-HRAM, followed by the standard diagnostic procedure for either CARM or Hirschsprung disease.

RESULTS:

Of the 51 patients who underwent both 3D-HRAM and ES, we observed that patients with rectoperineal CARM revealed a pressure gap along the anterior part of the anal sphincter. Based on this observation, we diagnosed 35 patients with CARM. Subsequently, all 35 diagnoses were confirmed with ES. Sixteen patients were diagnosed as not having CARM, 100% of whom were in agreement with the gold standard—ES. Both the specificity and sensitivity of 3D-HRAM for diagnosing rectoperineal CARM were 100%.

DISCUSSION:

We consider 3D-HRAM a reliable tool for diagnosing and excluding rectoperineal CARM. Using this method in patients suspected of CARM might keep infants from undergoing unnecessary interventions requiring anesthetics, such as ES. By providing objective insight into the functional capabilities of the anal sphincter, anorectal manometry adds to the diagnosis.
The Importance of the Holistic View in Urbanism: The Role of Physical Geography in the Sustainable City of the 21st Century
Authors: Cordeiro A. M. Rochette
Published: December 2022

The need for an interdisciplinary approach to urban planning is an undeniable fact in the 21st century vision of sustainable cities. Although in geography studies urban planning has always been regarded as a field of human geography, resilience to climate change and the importance of ecosystems in increasingly populated territories offer new perspectives to physical supports, in particular in urban design and in its relevance in environmental aspects of sustainable urban planning. This study takes an integrated approach to physical geography in order to understand urban environments through urban landscapes from a socio-natural standpoint. In the last decade, both at global level, through the Sustainable Development Goals (SDGs), and at European level, through directives and environmental programmes, such as the Urban Agenda for the EU and the European Climate Law, the adaptations of urban climate, air quality, and sustainable land-use contingent to nature-based solutions brought about new challenges and perspectives to the 21st century city. In this framework, the energy efficiency and decarbonisation issues were brought into the equation, being key elements in sustainable urban development. Adapting the sub-areas of physical geography to the different mosaics in urban spaces in a holistic manner by analysing endogenous factors – “morphological system” – and exogenous factors – climate –, as well as all those interconnected thereto downstream – hydrology, natural hazards, or the different environmental management and land-use and occupation instruments provides physical geographers with opportunities for the urbanisation of nature, in a temporal matrix, showing the trajectories of transformation of urban settlements.
Inspiracje dla misyjnej działalności Kościoła w encyklikach Benedykta XVI
Authors: Adamiak Grzegorz
Published: December 2022

The analysis carried out in the article indicates the truths about the Church contained in Benedict XVI’s encyclicals, which at the same time constitute specific inspirations for the missionary work of the Church ad gentes. The Pope does not distinguish between generally separate „missionary situations” and speaks rather of a single, fundamental, inalienable mission that still stands before the Church. Sometimes, however, he evokes the activity of the Church in mission areas. He reminds and points out that the Church’s ever-present task, including the mission ad gentes, is to remind and proclaim to the contemporary world the truth about God who is love. Missionary activity is also supposed to restore hope to modern man that goes beyond the temporal order. Finally, the Church’s mission, especially in the framework of her mission ad gentes, is to care for the true progress and development of every person and of the whole human society in truth and love. The missionary activity of the community Christ’s disciples remains a special area of such presence and witness of the Church in a world which is constantly globalizing.
Polscy jezuici na ziemiach greckich od XVI do XX wieku
Authors: Homa Krzysztof
Published: December 2022

The main purpose of this article is to provide some information about missionary work of Polish Jesuits in Greece and in Constantinople from XVI to XX century. It was the period of Turkokratia and later of Independent Greece. Article is divided into four small chapters. After a general introduction to the topic, the first chapter “Constantinople” is giving us some information about 18 Jesuits, who worked in Constantinople from XVI until XIX century. Second chapter presented Polish Jesuits who worked on Islands of Aegean Sea: Syros, Tinos, Chios in the XIX century, especially Fathers: Tadeusz Kuczyński, Dominik Osmołowski and Józef Skulina. Third chapter is about Jesuits traveling and working temporarily in Greece in XIX century and in the beginning of XX century, especially Fathers: Maksymilian Ryłło and Marcin Czermiński. Last chapter presented some Jesuits working in Athens in the XX century. Article finished with bibliography and information about Polonica in the Jesuit Archive in Athens. It is not very deep research but rather a kind of signal showing new topics for historic, scientific work.
Desatero kázanie božie
Authors: Všetička František
Published: December 2022

Satirické dílo Desatero kázanie božie ze 14. století je založeno na triadickém principu, jsou zde tři ukázky drobného provinění, dílo se skládá z dvanácti architektonických celků. Skladba je prostoupena exemply a je architektonicky zarámována prologem a epilogem. Text zaznamenaný in continuo naznačuje tendenci k dílčím strofettám.
K slavení já však zrozen jsem
Authors: Harák Ivo
Published: December 2022

Ivo Harák se ve své studii zabývá básnickým dílem jednoho z nejvýraznějších představitelů české spirituelní lyriky XX. století Jana Zahradníčka. Zevrubně analyzuje jeho básnické sbírky – využívaje při tom znalosti těch nejvýznamnějších textů sekundární literatury, které jsou věnovány Zahradníčkově tvorbě. Pokouší se narýsovat vývojovou linii Zahradníčkovy tvorby od jeho básnických počátků (Pokušení smrti) po rozvinutí Zahradníčkovy poetiky do půli třicátých let XX. století. Ukazuje při tom na myšlenkové a tvárné dominanty, jež se v Z. tvorbě opakují, variují a prohlubují. Harák zde také navazuje na pozornost, již věnoval obdobným autorům (především na své monografie Básník a jeho čas o Zdeňku Rotreklovi a Básník Josef Suchý).
O mniejszości greckiej w Kaliszu
Authors: Waszak Damian
Published: December 2022

Marcin Mikołajczyk, Grecka wspólnota w Kaliszu,Kaliskie Towarzystwo Przyjaciół Nauk, Kalisz 2018, ss. 234.
Sprawozdanie z seminarium naukowego "Paradyplomacja. Stan i perspektywy polskich badań
Authors: Ksenicz Igor
Published: December 2022

Sprawozdanie z seminarium naukowego "Paradyplomacja. Stan i perspektywy polskich badań|
Ulpia Topeiros. The Imperial Nomen Gentilicum in a city-title roman Thrace
Authors: Topalilov Ivo
Published: December 2022

This paper explores the reasons why ἡ Τοπειριτῶν πόλις obtained the Trajanic nomen gentilicium Οὐλπία in its title. The question arises since it appears on the municipal coin series minted for Topeiros at a particular moment in time, specifically in 212 AD. This coincides with an imperial visit which Caracalla and his mother Julia Domna paid in the city. The author argues that by using such propaganda gimmick, the local authority sought to attract the emperor’s attention to the privileges and most probably territorial extension granted byTrajan but later delayed by Hadrian. The lands in question had originally belonged to the neighboring city of Abdera. It appears that the town leaders of Topeiros succeeded, since an in scription dated to the reign of Maximinus Thrax (235-238) shows a vast extension of the municipality’s landhold eastwards.
Teorie spiskowe na temat wojny w Ukrainie
Authors: Jankowiak Adam
Published: December 2022

Rosyjska inwazja w Ukrainie jest bezprecedensowym wydarzeniem w najnowszej historii. Od końca lutego 2022 roku walki toczą się nie tylko na terytorium Ukrainy, ale też w przestrzeni medialnej, gdzie wykorzystywane są, zwłaszcza przez Rosjan, wszelkiego rodzaju fake newsy. W rosyjskich kampaniach dezinformacyjnych ważną rolę odgrywają teorie spiskowe. Są one mniej lub bardziej prawdopodobne, jednakże nie należy lekceważyć ich wpływu na postawy społeczne, co można było zaobserwować w minionych latach na przykładzie referendum, dotyczącego BREXIT-u czy wyborów prezydenckich w Stanach Zjednoczonych. W niniejszym artykule zostaną przeanalizowane teorie spiskowe, wykorzystywane przez rosyjską propagandę w trakcie inwazji w Ukrainie oraz ich wpływ na postawy społeczeństw, a nawet na politykę państw.
The Risk of Russia Using Nuclear Weapons Due to the War in Ukraine from the American Perspective
Authors: Jureńczyk Łukasz
Published: December 2022

The paper’s subject is the risk of using nuclear weapons by Russia in the context of the war in Ukraine. The aim is to analyze and evaluate such a possibility from the American perspective. The main research problem is whether, according to American scholars and experts, is it realistic for Russia to use nuclear weapons against Ukraine or NATO countries? From the perspective of the West, such a possibility cannot be ruled out, but the great majority of researchers and analysts believe that the risk is very small. If this happens, it will likely be the use of tactical nuclear weapons against military targets in Ukraine. It is less likely that tactical nuclear weapons will be launched against elements of the infrastructure used to transport weapons from the West to Ukraine, located in the countries of NATO’s eastern flank. The research used interviews conducted by the author in Washington and New York and the expertise of American think tanks. The analysis was carried out from the perspective of the paradigm of offensive neorealism.
Silencing TLR4 using an ultrasound-targeted microbubble destruction-based shRNA system reduces ischemia-induced seizures in hyperglycemic rats
Authors: Chen Jia , Huang Fami , Fang Xiaobo , Li Siying , Liang Yanling
Published: December 2022

The toll-like receptor 4 (TLR4) pathway is involved in seizures. We investigated whether ultrasound-targeted microbubble destruction (UTMD)-mediated delivery of short hairpin RNA (shRNA) targeting the TLR4 gene (shRNA-TLR4) can reduce ischemia-induced seizures in rats with hyperglycemia. A total of 100 male Wistar rats were randomly assigned to five groups: (1) Sham; (2) normal saline (NS); (3) shRNA-TLR4, where rats were injected with shRNA-TLR4; (4) shRNA-TLR4 + US, where rats were injected with shRNA-TLR4 followed by ultrasound (US) irradiation; and (5) shRNA-TLR4 + microbubbles (MBs) + US, where rats were injected with shRNA-TLR4 mixed with MBs followed by US irradiation. Western blot and immunohistochemical staining were used to measure TLR4-positive cells. Half of the rats in the NS group developed tonic-clonic seizures, and TLR4 expression in the CA3 region of the hippocampus was increased in these rats. In addition, the NS group showed an increased number of TLR4-positive cells compared with the Sham group, while there was a decreased number of TLR4-positive cells in the shRNA, shRNA + US, and shRNA + MBs + US groups. Our findings indicate that the TLR4 pathway is involved in the pathogenesis of ischemia-induced seizures in hyperglycemic rats and that UTMD technology may be a promising strategy to treat brain diseases.
GraphML-SBGN bidirectional converter for metabolic networks
Authors: Balaur Irina , Roy Ludovic , Touré Vasundra , Mazein Alexander , Auffray Charles
Published: December 2022

Systems biology researchers need feasible solutions for editing and visualisation of large biological diagrams. Here, we present the ySBGN bidirectional converter that translates metabolic pathways, developed in the general-purpose yEd Graph Editor (using the GraphML format) into the Systems Biology Graphical Notation Markup Language (SBGN-ML) standard format and vice versa. We illustrate the functionality of this converter by applying it to the translation of the ReconMap resource (available in the SBGN-ML format) to the yEd-specific GraphML and back. The ySBGN tool makes possible to draw extensive metabolic diagrams in a powerful general-purpose graph editor while providing results in the standard SBGN format.
Implementation of 10 Gbps optical wireless link for 200 km inter-aircraft optical communications
Authors: Sudhakar Muppidi Venkata , Rajini Gaddam Kesava Reddy
Published: December 2022

The enhancements related to optical devices are highly required for high-speed compact wireless optical transmission systems. This paper focuses on development and analysis of the communication system for inter-aircraft applications. The vertical cavity surface emitting laser (VCSEL) is employed at the transmitter for generating directly modulated non-return to zero (NRZ) signal. Direct detection along with Gaussian low pass filtering is employed in the receiver. The performance of the system is examined as well as compared with and without application of filtering at the receiver. The performance of optical wireless system is analyzed in terms of BER, eye-pattern, sensitivity, SNR, and Q-factor. The data rate is enhanced by 4-fold and transmission distance is improved by 250% in comparison with earlier inter-satellite links.
Wet tropospheric correction for satellite altimetry using SIRGAS-CON products
Authors: Prado Anderson , Vieira Telmo , Pires Nelson , Fernandes Maria Joana
Published: December 2022

The wet tropospheric correction (WTC) is a required correction to satellite altimetry measurements, mainly due to the atmospheric water vapor delay. On-board microwave radiometers (MWR) provide information for WTC estimation but fail in coastal zones and inland waters. In view to recover the WTC in these areas, the Global Navigation Satellite System (GNSS)-derived Path Delay Plus (GPD+) method, developed by the University of Porto, uses Zenith Tropospheric Delays from GNSS global and regional networks’ stations combined with other sources of information, providing a WTC solution for all along-track altimeter points. To densify the existing dataset used by GPD+, it is necessary to add new GNSS stations, mainly in the southern hemisphere, in regions such as South America, Africa and Oceania. This work aims to exploit the SIRGAS-CON data and its potential for densification of the GPD+ input dataset in Latin America and to improve GPD+ performance. The results for the three analyzed satellites (Sentinel-3A, Sentinel-3B and CryoSat-2) show that, when compared with the WTC from GNSS and radiosondes, the densified GPD+ WTC leads to a reduction in the RMS of the WTC differences with respect to the non-densified GPD+ solution, up to 2 mm for the whole region and up to 5 mm in some locations.
Structural characterization of fillers of inorganic materials in bismaleimide resins
Authors: Dash Ritambhara , Kommu Parameshwar , Kumari Neha , Bhattacharyya Arnab S.
Published: December 2022

Because of its dimensional stability, minimal shrinkage, chemical and fire resistance, good mechanical qualities and high resistance to a variety of solvents, acids and water, bismaleimide (BMI) thermosetting polymers are mostly employed in aerospace applications. Corrosion prevention has also been accomplished using BMI coating. The addition of inorganic materials like metal oxides can influence the properties of BMI as an inorganic–organic composite. Ferric chloride–bismaleimide (FeCl3–BMI) and titania–bismaleimide (TiO2–BMI) composites were synthesized. Fillers of inorganic compounds like MnO2, Ni (NO3)2·6H2O and Al2(SO4)3 were synthesized as well. The structural and crystalline configuration as well as physicochemical changes were thoroughly studied by XRD and Fourier transform infrared spectroscopy (FTIR).
Effect of spraying polyvinyl alcohol solution on the surface of liquid film on the structure and antifouling properties of polyvinylidene membrane
Authors: Xu Lang , Wang Chenyang , Shuai Qi , Li Hongjun , Zhang Hongwei , Zuo Danying
Published: December 2022

Polyvinylidene fluoride (PVDF) membrane was prepared by a two-step method of surface gelation-immersion precipitation. The surface of the scraping solution film was sprayed with polyvinyl alcohol (PVA) aqueous solution to gel the film surface first, and then the liquid film was immersed in a coagulation bath for phase transformation to obtain the surface modified PVDF membrane. The effects of PVA solution with different mass fraction on the structure and properties of PVDF membrane were studied. The results showed that with the increase of spraying PVA mass fraction, the contact angle of the upper surface of PVDF membranes gradually decreased, the porosity and mean pore size of PVDF membranes gradually increased, and the crystallinity of PVDF membranes gradually decreased. The pores on upper surface of the membranes first increased and then decreased, and the finger-like macropore structure appeared inside the membranes, the water flux first increased and then decreased, and the rejection rate increased. Dynamic cycle filtration experiment of bovine serum protein (BSA) solution showed an increase in membrane flux recovery from 68.31 to 95.08% and a decrease in the irreversible fouling rate from 31.69 to 4.92%, indicating an improvement in the hydrophilicity and antifouling properties of the modified PVDF membrane.
Delivery systems in nanocosmeceuticals
Authors: Martel-Estrada Santos-Adriana , Morales-Cardona Andrea-Isabel , Vargas-Requena Claudia-Lucía , Rubio-Lara Juan-Antonio , Martínez-Pérez Carlos-Alberto , Jimenez-Vega Florinda
Published: December 2022

Today, the growth of the cosmetic industry and dramatic technological advances have led to the creation of functional cosmetical products that enhance beauty and health. Such products can be defined as topical cosmetic drugs to improve health and beauty functions or benefits. Implementing nanotechnology and advanced engineering in these products has enabled innovative product formulations and solutions. The search included organic molecules used as cosmeceuticals and nanoparticles (NPs) used in that field. As a result, this document analyses the use of organic and inorganic particles, metals, metal-oxides, and carbon-based particles. Additionally, this document includes lipid and nanoparticles solid lipid systems. In conclusion, using NPs as vehicles of active substances is a potential tool for transporting active ingredients. Finally, this review includes the nanoparticles used in cosmeceuticals while presenting the progress made and highlighting the hidden challenges associated with nanocosmeceuticals.
A Layered, Hybrid Machine Learning Analytic Workflow for Mouse Risk Assessment Behavior
Authors: Wang Jinxin , Karbasi Paniz , Wang Liqiang , Meeks Julian P.
Published: December 2022

Accurate and efficient quantification of animal behavior facilitates the understanding of the brain. An emerging approach within machine learning (ML) field is to combine multiple ML-based algorithms to quantify animal behavior. These so-called hybrid models have emerged because of limitations associated with supervised [e.g., random forest (RF)] and unsupervised [e.g., hidden Markov model (HMM)] ML models. For example, RF models lack temporal information across video frames, and HMM latent states are often difficult to interpret. We sought to develop a hybrid model, and did so in the context of a study of mouse risk assessment behavior. We used DeepLabCut to estimate the positions of mouse body parts. Positional features were calculated using DeepLabCut outputs and were used to train RF and HMM models with equal number of states, separately. The per-frame predictions from RF and HMM models were then passed to a second HMM model layer (“reHMM”). The outputs of the reHMM layer showed improved interpretability over the initial HMM output. Finally, we combined predictions from RF and HMM models with selected positional features to train a third HMM model (“reHMM+”). This reHMM+ layered hybrid model unveiled distinctive temporal and human-interpretable behavioral patterns. We applied this workflow to investigate risk assessment to trimethylthiazoline and snake feces odor, finding unique behavioral patterns to each that were separable from attractive and neutral stimuli. We conclude that this layered, hybrid ML workflow represents a balanced approach for improving the depth and reliability of ML classifiers in chemosensory and other behavioral contexts.
Derviş Hasan Medhî nin “Terceme-i Şeh-nâme-i Firdevsî” Adlı Eserinin Bilinmeyen Bir Nüshası
Authors: AKARVARDAR KOÇAK S. Zehra
Published: December 2022

Firdevsî’nin anıtsal eseri Şeh-nâme dünya klasikleri arasında mühim bir yere sahiptir. Eser, İran’ın millî destanı kabul edilmekle birlikte şöhreti bu coğrafya ile sınırlı kalmamış farklı kültür havzalarına ulaşarak tesir dairesini genişletmiştir. Şeh-nâme bu tanınırlığını müellifin birçok şaire ilham kaynağı olan üslûbunun yanında farklı dillere tercüme edilmesine borçludur. Osmanlı dönemindeki ilk Türkçe tercümesi II. Murad dönemine tekâbül eden esere padişahlar da ilgi göstermiştir. Bu padişahlardan biri olan II. Osman eserin tercüme edilmesini emretmiş ve bu vazifeyi uzun süre sarayda kıssa-hân olarak bulunan Derviş Hasan Medhî’ye vermiştir. Eser iki cilt halinde tercüme edilmiş, bir seti padişaha bir seti muhtemelen Dârüssaâde Ağası Mustafa Ağa’ya sunulmak üzere iki set şeklinde hazırlanmıştır. Bu tercümeye dair mevcut nüshalar dünyanın farklı kütüphanelerindeki üç nüshadan ibaretti. Bu çalışmada, bahse konu tercümenin tarafımızca tespit edilen dördüncü nüshası tanıtılmıştır. Nüshayı tanıtmaya başlamadan önce Şeh-nâme tercümeleri, müellifin kimliği ve eserlerinden bahsedilmiş ardından tespit edilen nüshanın özellikleri hakkında bilgi verilmiştir.
Divan Şâiri Maksadî ve Şiir Mecmûalarında Tespit Edilen Gazelleri
Authors: Yeşilbağ Semih
Published: December 2022

Osmanlı Devleti’nin 14. yüzyıldan itibaren kademeli bir ilerleyişle Rumeli ve Balkan coğrafyasında etkili olmaya başladığı bilinmektedir. Belgrat, Bosna, Filibe, Manastır, Mostar, Priştine, Prizren, Saraybosna, Serez, Sofya, Üsküp, Vardar Yenicesi gibi şehirlerde Osmanlı kültürü etkisinde oluşan edebî muhitlerde önemli sanatçılar yetişmiştir. Bu sanatçılar, Anadolu ile Balkan coğrafyası arasında gönül köprüleri kurarak ana çizgileriyle müşterek bir dünya görüşünün ve edebî anlayışın ortaya konduğu eserler vermişlerdir. Bu sanatçıların eserlerinin önemli bir kısmı bugün ilim camiasına kazandırılmış, çoğu üzerinde farklı içerikte çalışmalar yapılmıştır. Bununla birlikte yapılan yeni çalışmalarla ortaya konan eserler, hâlen hayatları ve eserleriyle ilim âlemine tanıtılmayı bekleyenler olduğunu göstermektedir. Bu bağlamda şiir mecmûalarının ilim dünyasında bilinmeyen şair ve şiirlerin tespitinde ne denli önemli olduğu, klasik edebiyatla ilgili çalışma yapanların malumudur. Bu çalışmada kaynaklarda hakkında bilgiye rastlanmadığı için ancak eserlerinden hareketle hayatı hakkında bilgi sahibi olunan ve Balkan coğrafyasının yetiştirdiği bir sanatçı olan Maksadî mahlaslı bir şairin yayımlanmamış gazelleri de şiir mecmûalarından temin edilmiştir. Makalede Maksadî’nin hayatı, sanatı ve eserlerine dair bazı hususlara değinildikten sonra şairin gazel nazım biçimindeki şiirleri çeviri yazıya aktarılarak verilmiş, çalışmaya eserden örnek sayfalar da eklenmiştir. Bu çalışma ile Maksadî’nin ve gazellerinin ilim âleminin gündemine taşınması hedeflenmiştir.
Cytosolic stress granules relieve the ubiquitin‐proteasome system in the nuclear compartment
Authors: Xu Shanshan , Gierisch Maria E , Schellhaus Anna Katharina , Poser Ina , Alberti Simon , Salomons Florian A , Dantuma Nico P
Published: December 2022

The role of cytosolic stress granules in the integrated stress response has remained largely enigmatic. Here, we studied the functionality of the ubiquitin‐proteasome system (UPS) in cells that were unable to form stress granules. Surprisingly, the inability of cells to form cytosolic stress granules had primarily a negative impact on the functionality of the nuclear UPS. While defective ribosome products (DRiPs) accumulated at stress granules in thermally stressed control cells, they localized to nucleoli in stress granule‐deficient cells. The nuclear localization of DRiPs was accompanied by redistribution and enhanced degradation of SUMOylated proteins. Depletion of the SUMO‐targeted ubiquitin ligase RNF4, which targets SUMOylated misfolded proteins for proteasomal degradation, largely restored the functionality of the UPS in the nuclear compartment in stress granule‐deficient cells. Stress granule‐deficient cells showed an increase in the formation of mutant ataxin‐1 nuclear inclusions when exposed to thermal stress. Our data reveal that stress granules play an important role in the sequestration of cytosolic misfolded proteins, thereby preventing these proteins from accumulating in the nucleus, where they would otherwise infringe nuclear proteostasis.
DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma
Authors: Taffoni Clara , Marines Johanna , Chamma Hanane , Guha Soumyabrata , Saccas Mathilde , Bouzid Amel , Valadao Ana‐Luiza Chaves , Maghe Clément , Jardine Jane , Park Mi Kyung , Polak Katarzyna , De Martino Mara , Vanpouille‐Box Claire , Del Rio Maguy , Gongora Celine , Gavard Julie , Bidère Nicolas , Song Min Sup , Pineau Donovan , Hugnot Jean‐Philippe , Kissa Karima , Fontenille Laura , Blanchet Fabien P , Vila Isabelle K , Laguette Nadine
Published: December 2022

Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP (cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used glioblastoma cells that show undetectable cGAS levels to address if alternative DNA detection pathways can promote pro‐inflammatory signaling. We show that the DNA‐PK DNA repair complex (i) drives cGAS‐independent IRF3‐mediated type I Interferon responses and (ii) that its catalytic activity is required for cGAS‐dependent cGAMP production and optimal downstream signaling. We further show that the cooperation between DNA‐PK and cGAS favors the expression of chemokines that promote macrophage recruitment in the tumor microenvironment in a glioblastoma model, a process that impairs early tumorigenesis but correlates with poor outcome in glioblastoma patients. Thus, our study supports that cGAS‐dependent signaling is acquired during tumorigenesis and that cGAS and DNA‐PK activities should be analyzed concertedly to predict the impact of strategies aiming to boost tumor immunogenicity.
Relative assessment of various annular fin shapes for heat transfer and pressure penalty
Authors: Shah Mayank , Shah Dr. Rupesh
Published: December 2022

Three dimensional numerical investigations are carried out to analyse the effect of different shapes of annular fin on heat transfer characteristics and pressure drop across a tube surface. Shear stress transport based k-ω turbulence model is used to analyse flow physics and heat transfer characteristics in flow domain. Weak zones of heat transfer across a circular tube surface are identified for 2500 < Re < 13000. Three different shapes of annular fin are considered to test the possibility of optimum heat transfer characteristics in weak zones. Results are compared with circular shape annular fin. Circular shape annular fin outperforms in terms of overall rate of heat transfer at the cost of highest pressure drop. The heat transfer rate decreases by 18%, 21% and 31% in sectorial fin, elliptical fin and sectional fin as compared to that of circular fin at 12965 Reynolds number, but at other end pressure drop across a tube surface in case of these fins also decrease as compared to that of circular annular fin. Potential rate, ratio of heat transfer rate to required pumping power, is calculated to evaluate optimum fin performance. Potential rate of an elliptical fin is highest among all the reported cases.
The Challenges of Religious Harmony and Tolerance in Developing Countries
Authors: Sari Anggun Putri Indah
Published: December 2022

This study aims to analyze how the challenges of religious harmony and tolerance in Indonesia are in the social and legal aspects. This study uses a literature study approach by comparing several legal regulations and previous research related to secondary data. This study found that religious harmony is a state of inter-religious relations based on tolerance, mutual understanding, mutual respect, respect for equality in the practice of their religious teachings and cooperation in social, national and state life within the Republic of Indonesia based on Pancasila and the 1945 Constitution of Indonesia. The right to religion (to embrace and practice worship) guaranteed by the Constitution and other laws is not a right that can be exercised at will. This means that there are certain signs or conditions so that the exercise of that right does not interfere with the rights of other people, the security and order of the community, the state and the nation; in other words, there are restrictions that must be considered by residents. This limitation is in Article 28J paragraph (2) of the 1945 Constitution in conjunction with Article 73 of the Human Rights Law. Article 28J paragraph (2) stipulates that in exercising their rights and freedoms, everyone is obliged to comply with the restrictions determined by law with the sole purpose of guaranteeing recognition and respect for the rights and freedoms of others and to fulfill fair demands in accordance with moral considerations, religious values, security, and public order in a democratic society.
A Pseudo Freedom for Faith: A Discourse of Religious Freedom in Russia and Indonesia
Authors: Arvante Jeremy Zefanya Yaka , Nugraha Maulana Fuad , Arifin Ridwan
Published: December 2022

This paper is a study or comparative study between Indonesia and Russia on the regulation of one of the fundamental rights in human rights, namely the right to freedom of religion. As a constitutional state based on law, Indonesia and Russia have made arrangements for this in their constitutions, the most basic of which is contained in the 1945 Constitution (Indonesia) and The Constitution of the Russian Federation (Russia). General rules such as human rights play an important role as an instrument that ensures the preservation of the rights of citizens and the implementation of state functions to fulfill these rights. The right to freedom of religion is one of the rights guaranteed in Article 19 of The Constitution of the Russian Federation, and the 1945 Constitution. Article 19 of the Russian constitution states that The State shall guarantee the equality of rights and freedoms of man and citizen, regardless of sex, race, religion, and also of other circumstances. All forms of limitations of human rights shall be banned. And Article 28I paragraph 1 of the 1945 Constitution states that the right to religion is stated as a right that cannot be reduced under any circumstances, as well as the right to life, the right not to be tortured, the right to freedom of thought and conscience, the right not to be enslaved, the right to be recognized as a human being. person before the law, and the right not to be prosecuted on the basis of retroactive law.
Synthesis of donor-acceptor compounds based on azulene
Authors: Merkhatuly Nurlan , Iskanderov Amantay , Zhokizhanova Saltanat , Erniyazova Bibizhan
Published: December 2022

At present, non-benzenoid aromatic hydrocarbons are widely used as precursors for the synthesis of new materials with useful electronic properties. In particular, the non-alternative aromatic hydrocarbon azulen with a unique dipole structure and a tendency to form stabilized radical ions should be predetermined as a building block for obtaining new π-conjugated systems with interesting optoelectronic properties. This article discusses the directed synthesis and study of optical properties of new donor-acceptor compounds based on azulene. It was shown that for the synthesis of donor-acceptor phenylketone azulenes, the reaction of directed (to positions С1 and С3) acylation with benzoyl chloride in the presence of Li2MnCl4 in tetrahydrofuran was used for the first time as a key step. It was found that push-pull phenyldicyanovinyl azulenes obtained by Knoevenagel condensation of azulenylketones with malononitrile flow easily (with an increase in the yield of end products) in the presence of pyridine in dimethyl sulfoxide. Electron UV-visible spectra of phenyldicyanovinyl azulene compounds showed strong absorption bands in the visible region (λmax = 452 and 434 nm) caused by intense intramolecular charge transfer between the donor azulene ring and the acceptor phenyldicyanovinyl group.
Cambio climático en experiencias educativas de profesorado universitario
Authors: Maldonado-González Ana Lucía
Published: December 2022

Objetivo. Conocer y analizar las posibilidades para integrar el cambio climático (CC) en experiencias educativas de nivel superior con profesorado de la Universidad Veracruzana (UV), en la sede Poza Rica-Tuxpan. Por su ubicación geográfica, la región está expuesta a fenómenos hidrometeorológicos extremos, hay vulnerabilidad física y social. Metodología. Se realizaron entrevistas grupales con profesorado para indagar sobre las amenazas asociadas al CC que identifican en su región y cómo abordan este fenómeno desde su actividad académica y práctica docente. Se retoma como categoría sustantiva la dimensión de actitudes desde la teoría de las representaciones sociales; las categorías formales se adhieren a los enfoques de riesgo, vulnerabilidad y resiliencia social, pertinentes a la región de estudio. Para las entrevistas grupales se elaboró una guía semiestructurada, las entrevistas fueron audiograbadas y transcritas textualmente para su análisis siguiendo la técnica de análisis de contenido. Resultados. Las personas participantes identifican y abordan, en sus experiencias educativas, el CC y otras amenazas asociadas a este fenómeno. Se reconoce una práctica docente comprometida con la problemática ambiental de su propio contexto. Además, la vinculación con otros actores sociales, municipales y comunitarios, quienes colaboran en prácticas educativas para reducir vulnerabilidades, promover la gestión del riesgo y avanzar en el proceso de coconstrucción de resiliencia social, donde se consideran medidas de adaptación y mitigación al CC. Conclusiones. La acción educativa contribuye, así, a la acción climática, fortaleciendo capacidades individuales y colectivas, sin duda necesarias para frenar la crisis climática actual.
Influencia de la música en la neuroquímica positiva: una visión general
Authors: Corrales Heras María Rosa , García Rodríguez María
Published: December 2022

La música es un estímulo ampliamente extendido en la sociedad ya que escuchar música tiene un impacto beneficioso en niveles de bienestar. Esta revisión narrativa tiene como objetivo principal dar a conocer los hallazgos previos sobre la eficacia de la escucha musical, la práctica instrumental o vocal y la musicoterapia desde diferentes perspectivas relacionadas con la mejora del bienestar, analizando literatura de impacto sobre este tema para conocer las técnicas, objetivos, instrumentos de evaluación y resultados más frecuentes. Se ha llevado a cabo una búsqueda estratégica a través de la consulta en bases de datos científicas. Se realizaron búsquedas en las siguientes bases de datos electrónicas internacionales: PubMed, Medline, Ovid, Cochrane Library, Google Scholar, REDALYC, Dialnet, SciELO y DOAJ. Se identificaron un total de 121 fuentes de las cuales se incluyeron 51 artículos en esta revisión. En los estudios se utilizaron técnicas de musicoterapia tanto receptivas como activas, escucha musical y práctica instrumental o vocal. Aunque esta revisión de la literatura identificó numerosos artículos de calidad contrastada, dada la heterogeneidad y la calidad metodológica de algunas de las investigaciones incluidas, es complejo extrapolar y generalizar resultados. De este modo, se considera necesario realizar más investigaciones con planteamientos metodológicos rigurosos que permitan divulgar resultados en este ámbito.