bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimising monitoring efforts for secretive snakes: a comparison of occupancy and N-mixture models for assessment of population status
Authors: Ward Robert J. , Griffiths Richard A. , Wilkinson John W. , Cornish Nina
Published: December 2017

A fifth of reptiles are Data Deficient; many due to unknown population status. Monitoring snake populations can be demanding due to crypsis and low population densities, with insufficient recaptures for abundance estimation via Capture-Mark-Recapture. Alternatively, binomial N-mixture models enable abundance estimation from count data without individual identification, but have rarely been successfully applied to snake populations. We evaluated the suitability of occupancy and N-mixture methods for monitoring an insular population of grass snakes (Natrix helvetica) and considered covariates influencing detection, occupancy and abundance within remaining habitat. Snakes were elusive, with detectability increasing with survey effort (mean: 0.33 ± 0.06 s.e.m.). The probability of a transect being occupied was moderate (mean per kilometre: 0.44 ± 0.19 s.e.m.) and increased with transect length. Abundance estimates indicate a small threatened population associated to our transects (mean: 39, 95% CI: 20–169). Power analysis indicated that the survey effort required to detect occupancy declines would be prohibitive. Occupancy models fitted well, whereas N-mixture models showed poor fit, provided little extra information over occupancy models and were at greater risk of closure violation. Therefore we suggest occupancy models are more appropriate for monitoring snakes and other elusive species, but that population trends may go undetected.
Alternative dominance of the parental genomes in hybrid cells generated through the fusion of mouse embryonic stem cells with fibroblasts
Authors: Matveeva Natalia M. , Fishman Veniamin S. , Zakharova Irina S. , Shevchenko Alexander I. , Pristyazhnyuk Inna E. , Menzorov Aleksei G. , Serov Oleg L.
Published: December 2017

For the first time, two types of hybrid cells with embryonic stem (ES) cell-like and fibroblast-like phenotypes were produced through the fusion of mouse ES cells with fibroblasts. Transcriptome analysis of 2,848 genes differentially expressed in the parental cells demonstrated that 34–43% of these genes are expressed in hybrid cells, consistent with their phenotypes; 25–29% of these genes display intermediate levels of expression, and 12–16% of these genes maintained expression at the parental cell level, inconsistent with the phenotype of the hybrid cell. Approximately 20% of the analyzed genes displayed unexpected expression patterns that differ from both parents. An unusual phenomenon was observed, namely, the illegitimate activation of Xist expression and the inactivation of one of two X-chromosomes in the near-tetraploid fibroblast-like hybrid cells, whereas both Xs were active before and after in vitro differentiation of the ES cell-like hybrid cells. These results and previous data obtained on heterokaryons suggest that the appearance of hybrid cells with a fibroblast-like phenotype reflects the reprogramming, rather than the induced differentiation, of the ES cell genome under the influence of a somatic partner.
Intravitreal injections of anti-VEGF agents and antibiotic prophylaxis for endophthalmitis: A systematic review and meta-analysis
Authors: Bande Manuel F. , Mansilla Raquel , Pata María P. , Fernández Maribel , Blanco-Teijeiro María José , Piñeiro Antonio , Gómez-Ulla Francisco
Published: December 2017

We performed a systematic review and meta-analysis to determine whether the use of local antibiotics is a beneficial prophylactic treatment for endophthalmitis in patients treated with anti-VEGF agents. We searched the MEDLINE and EMBASE databases, and the Cochrane Library over the period January 2007 to December 2016. The search terms used included “Endophthalmitis”, “Antibiotic” and “Intravitreal injection”. Studies in which the patients were treated exclusively with intravitreal injections of anti-VEGF were selected. Eight studies fit the inclusion criteria, which included a total of 276,774 injections; 109,178 (39.45%) were associated with the use of antibiotics and 114,821 (60.55%) were not associated with the use of antibiotics. Our meta-analysis indicated a significant risk for endophthalmitis that was 1.70 times greater with the use of antibiotics than that without antibiotics, with a confidence interval of 1.08 to 2.66 (p = 0.02). A meta-regression indicated that the location (operating rooms versus outpatient clinics) of injection did not have a significant effect on the incidence of endophthalmitis. The prophylactic use of antibiotics when administering anti-VEGF intravitreal injections may contribute to a greater incidence of endophthalmitis. This finding, in addition to reducing costs, would eliminate a treatment that has been shown to be unnecessary and even harmful to patients.
Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model
Authors: Pearson James T. , Yoshimoto Misa , Chen Yi Ching , Sultani Rohullah , Edgley Amanda J. , Nakaoka Hajime , Nishida Makoto , Umetani Keiji , Waddingham Mark T. , Jin Hui-Ling , Zhang Yuan , Kelly Darren J. , Schwenke Daryl O. , Inagaki Tadakatsu , Tsuchimochi Hirotsugu , Komuro Issei , Yamashita Shizuya , Shirai Mikiyasu
Published: December 2017

Reduced clearance of lipoproteins by HDL scavenger receptor class B1 (SR-B1) plays an important role in occlusive coronary artery disease. However, it is not clear how much microvascular dysfunction contributes to ischemic cardiomyopathy. Our aim was to determine the distribution of vascular dysfunction in vivo in the coronary circulation of male mice after brief exposure to Paigen high fat diet, and whether this vasomotor dysfunction involved nitric oxide (NO) and or endothelium derived hyperpolarization factors (EDHF). We utilised mice with hypomorphic ApoE lipoprotein that lacked SR-B1 (SR-B1−/−/ApoER61h/h, n = 8) or were heterozygous for SR-B1 (SR-B1+/−/ApoER61h/h, n = 8) to investigate coronary dilator function with synchrotron microangiography. Partially occlusive stenoses were observed in vivo in SR-B1 deficient mice only. Increases in artery-arteriole calibre to acetylcholine and sodium nitroprusside stimulation were absent in SR-B1 deficient mice. Residual dilation to acetylcholine following L-NAME (50 mg/kg) and sodium meclofenamate (3 mg/kg) blockade was present in both mouse groups, except at occlusions, indicating that EDHF was not impaired. We show that SR-B1 deficiency caused impairment of NO-mediated dilation of conductance and microvessels. Our findings also suggest EDHF and prostanoids are important for global perfusion, but ultimately the loss of NO-mediated vasodilation contributes to atherothrombotic progression in ischemic cardiomyopathy.
11.5% efficiency of TiO2 protected and Pt catalyzed n+np+-Si photocathodes for photoelectrochemical water splitting: manipulating the Pt distribution and Pt/Si contact
Authors: Yin Zhihao , Fan Ronglei , Huang Guanping , Shen Mingrong
Published: December 2017

A combination of hydrogen passivation, electroless deposition of a Pt catalyst and coating a TiO2 layer is very effective to get highly efficient and stable n+np+-Si photocathodes.
2D laser lithography on silicon substrates via photoinduced copper-mediated radical polymerization
Authors: Laun Joachim , De Smet Yana , Van de Reydt Emma , Krivcov Alexander , Trouillet Vanessa , Welle Alexander , Möbius Hildegard , Barner-Kowollik Christopher , Junkers Tanja
Published: December 2017

A 2D laser lithography protocol for controlled grafting of polymer brushes in a single-step is presented.
Revealing at the molecular level the role of the surfactant in the enhancement of the thermal properties of the gold nanofluid system used for concentrating solar power
Authors: Martín Elisa I. , Sánchez-Coronilla Antonio , Navas Javier , Gómez-Villarejo Roberto , Martínez-Merino Paloma , Alcántara Rodrigo , Fernández-Lorenzo Concha
Published: December 2017

A surfactant acts as a kind of net around gold that enhances at the molecular level the gold nanofluid thermal properties.
Dynamic wetting of imidazolium-based ionic liquids on gold and glass
Authors: Delcheva I. , Beattie D. A. , Ralston J. , Krasowska M.
Published: December 2017

Experimental data and theoretical fitting for ionic liquid wetting on application-relevant substrates.
In6S7 nanoparticle-embedded and sulfur and nitrogen co-doped microporous carbons derived from In(tdc)2 metal–organic framework
Authors: Choi In-Hwan , Jang So-Young , Kim Hyun-Chul , Huh Seong
Published: December 2017

Indium sulfide nanoparticle (NP)-embedded microporous carbons co-doped with S- and N-dopants are easily prepared by a direct carbonization of the as-prepared In(iii)-based metal–organic framework.
Water oxidation by simple manganese salts in the presence of cerium(iv) ammonium nitrate: towards a complete picture
Authors: Heidari Sima , Najafpour Mohammad Mahdi , Hołyńska Małgorzata , Singh Jitendra Pal , Chae Keun Hwa , Khatamian Masoumeh
Published: December 2017

For the first time, using some methods, we showed that under the water-oxidation conditions and in the presence of cerium(iv) ammonium nitrate, some manganese salts are converted to Mn oxide.
Exploring physical and chemical properties in new multifunctional indium-, bismuth-, and zinc-based 1D and 2D coordination polymers
Authors: Gomez G. E. , D'vries R. F. , Lionello D. F. , Aguirre-Díaz L. M. , Spinosa M. , Costa C. S. , Fuertes M. C. , Pizarro R. A. , Kaczmarek A. M. , Ellena J. , Rozes L. , Iglesias M. , Van Deun R. , Sanchez C. , Monge M. A. , Soler-Illia G. J. A. A.
Published: December 2017

Main group element CPs are important compounds for the development of multifunctional materials.
Unlocking the door to highly active ORR catalysts for PEMFC applications: polyhedron-engineered Pt-based nanocrystals
Authors: Wang Yan-Jie , Long Wenyu , Wang Lele , Yuan Rusheng , Ignaszak Anna , Fang Baizeng , Wilkinson David P.
Published: December 2017

This review focuses on polyhedron-engineered Pt-based nanocrystals as highly active ORR catalysts for PEMFCs.
Development of antioxidant gliadin particle stabilized Pickering high internal phase emulsions (HIPEs) as oral delivery systems and the in vitro digestion fate
Authors: Zhou F. Z. , Zeng T. , Yin S. W. , Tang C. H. , Yuan D. B. , Yang X. Q.
Published: December 2017

In this paper, we demonstrate for the first time the use of gliadin particles to structure algal oil (rich in DHA) and to exert chemical stability against lipid oxidation via the Pickering high internal phase emulsion (HIPE) strategy.
Laser-ablation MC-ICP-MS lead isotope microanalysis down to 10 μm: application to K-feldspar inclusions within zircon
Authors: Delavault Hélène , Dhuime Bruno , Hawkesworth Chris , Marschall Horst R.
Published: December 2017

A routine procedure is presented to analyse Pb isotopes in K-feldspar minerals and mineral inclusions in zircon by LA-MC-ICP-MS, with a spot size down to 10 μm.
A structure–activity relationship study using DFT analysis of Bronsted–Lewis acidic ionic liquids and synergistic effect of dual acidity in one-pot conversion of glucose to value-added chemicals
Authors: Parveen Firdaus , Patra Tanmoy , Upadhyayula Sreedevi
Published: December 2017

The catalytic conversion of biomass-derived carbohydrates to value-added chemicals, such as 5-hydroxymethylfurfural, levulinic acid, and formic acid, is a commercially important reaction and requires the use of both Lewis and Bronsted acids.
High photodegradation and antibacterial activity of BN–Ag/TiO2 composite nanofibers under visible light
Authors: Nasr M. , Soussan L. , Viter R. , Eid C. , Habchi R. , Miele P. , Bechelany M.
Published: December 2017

To develop material with good photocatalytic properties for organic compound degradation and bacterial removal, we produced Ag/TiO2 and BN–Ag/TiO2 composite nanofibers that included controlled amounts of boron nitride (BN) nanosheets and silver (Ag).
Syntheses, spectroscopic and crystallographic characterizations ofcis- andtrans-dispirocyclic ferrocenylphosphazenes: molecular dockings, cytotoxic and antimicrobial activities
Authors: Tümer Yasemin , Asmafiliz Nuran , Zeyrek C. Tuğrul , Kılıç Zeynel , Açık Leyla , Çelik S. Pınar , Türk Mustafa , Çağdaş Tunalı B. , Ünver Hüseyin , Hökelek Tuncer
Published: December 2017

The crystallographic and molecular docking investigations and the determinations of the cytotoxic activities of the dispirocyclic ferrocenylphosphazenes were performed.
Sensitive ratiometric detection of Al(iii) ions in a 100% aqueous buffered solution using a fluorescent probe based on a peptide receptor
Authors: Hwang Gi Won , Jeon Jongyong , Neupane Lok Nath , Lee Keun-Hyeung
Published: December 2017

The peptidyl bioprobe detected Al(iii) ions sensitively in a 100% aqueous buffered solution through ratiometric response.
Exploring and exploiting different catalytic systems for the direct conversion of cellulose into levulinic acid
Authors: Chiappe Cinzia , Rodriguez Douton Maria J. , Mezzetta Andrea , Guazzelli Lorenzo , Pomelli Christian S. , Assanelli Giulio , de Angelis Alberto Renato
Published: December 2017

The single step conversion of cellulose into levulinic acid has been studied under hydrothermal conditions with several catalytic systems.
Insights into the rheological behaviors and tribological performances of lubricating grease: entangled structure of a fiber thickener and functional groups of a base oil
Authors: Xu Nan , Wang Xiaobo , Ma Rui , Li Weimin , Zhang Ming
Published: December 2017

Influence of microstructure and composition of lubricating grease on rheological behavior and tribological performances.
Significant enhancement in thermoelectric performance of nanostructured higher manganese silicides synthesized employing a melt spinning technique
Authors: Muthiah Saravanan , Singh R. C. , Pathak B. D. , Avasthi Piyush Kumar , Kumar Rishikesh , Kumar Anil , Srivastava A. K. , Dhar Ajay
Published: December 2017

An unprecedented ZT ∼ 0.82 realized in spark plasma sintered Al-doped MnSi1.73 HMS, melt spun at high cooling rates.
Heat flux induced coherent vibration of H-shaped single layer graphene structure
Authors: Li W. , Chen J. , Zhao H. , Li G.
Published: December 2017

Steady state heat flow can generate sustained coherent mechanical vibrations in H-shaped graphene lattices.
Gold promoted arylative cyclization of alkynoic acids with arenediazonium salts
Authors: Carrillo-Arcos Ulises A. , Porcel Susana
Published: December 2017

Arylgold(iii) species generated from arenediazonium salts and Au(i) under thermal conditions promote the arylative cyclization of alkynoic acids leading to tetrasubstituted lactones.
Can strand displacement take place in DNA triplexes?
Authors: Li Qian , Tian Cheng , Li Xiang , Mao Chengde
Published: December 2017

Toehold-mediated strand displacement can take place in the context of DNA triplexes, slowly.
Fish oil affects the metabolic process of trimethylamine N-oxide precursor through trimethylamine production and flavin-containing monooxygenase activity in male C57BL/6 mice
Authors: Yu Jie , Zhang Tiantian , Gao Xiang , Xue Changhu , Xu Jie , Wang Yuming
Published: December 2017

Fish oil supplements could affect TMAO metabolic process through gut microbiota and FMOs.
Linking slow dynamics and microscopic connectivity in dense suspensions of charged colloids
Authors: Higler Ruben , Krausser Johannes , van der Gucht Jasper , Zaccone Alessio , Sprakel Joris
Published: December 2017

We directly observe and quantify the connectivity dynamics in liquids of charged colloids undergoing vitrification using confocal microscopy and use these data to extend Dyre's model to account for particle-level structural dynamics.
Cumulative energy analysis of thermally-induced surface wrinkling of heterogeneously multilayered thin films
Authors: Yoo Seong Soo , Choi Gwan H. , Lee Wooseop , Park Juhyun , Yi Gi-Ra , Ryu Du Yeol , Yoo Pil J.
Published: December 2017

Polymer/metal multilayers are thermally treated to generate surface wrinkles, then interpreted with cumulative energy balance analysis to reflect the individual elastic contribution of each constituent layer.
Annular and threadlike wormlike micelles formed by a bio-based surfactant containing an extremely large hydrophobic group
Authors: Zhai Zhaolan , Yan Xinyan , Song Zhanqian , Shang Shibin , Rao Xiaoping
Published: December 2017

The overlap of an alkyl chain and a rigid group in C12-MPA-Na promotes the formation of large spherical micelles and annular and threadlike micelles.
Viscoelastic wormlike micelles formed by ionic liquid-type surfactant [C16imC8]Br towards template-assisted synthesis of CdS quantum dots
Authors: Hu Yimin , Han Jie , Ge Lingling , Guo Rong
Published: December 2017

Viscoelastic wormlike micelles consisting of the ionic liquid-type surfactant [C16imC8]Br were utilized for the synthesis of CdS quantum dots.
Monolithic mesoporous graphitic composites as super capacitors: from Starbons to Starenes®
Authors: García Andrea Muñoz , Budarin Vitaliy L. , Zhou Yixin , De bruyn Mario , Hunt Andrew J. , Lari Leonardo , Lazarov Vlado K. , Salavagione Horacio J. , Morales Enrique , Ellis Gary J. , Clark James H. , Shuttleworth Peter S.
Published: December 2017

Sustainable electric double-layer capacitor (EDLC) electrodes were made by incorporating nano-graphite particles into the electrode pore walls, improving conductivity and capacitance. The combination of ball milling, microwave processing and carbonisation were key to excellent nanoparticle dispersion.
A promising metal–organic framework (MOF), MIL-96(Al), for CO2 separation under humid conditions
Authors: Benoit Virginie , Chanut Nicolas , Pillai Renjith S. , Benzaqui Marvin , Beurroies Isabelle , Devautour-Vinot Sabine , Serre Christian , Steunou Nathalie , Maurin Guillaume , Llewellyn Philip L.
Published: December 2017

Water adsorbed in MIL-96(Al) proffers a significant increase in affinity for CO2 with only a limited decrease in uptake.
Synergistic effects of chlorination and a fully two-dimensional side-chain design on molecular energy level modulation toward non-fullerene photovoltaics
Authors: Chao Pengjie , Wang Huan , Mo Daize , Meng Hong , Chen Wei , He Feng
Published: December 2017

By taking the advantage of chlorination and fully conjugated side chains, 2D-PBTCl shows a PCE of up to 8.81% in non-fullerene solar cells, which corresponds to an approximately 28% improvement compared to that of PTB7-Th-based devices.
Organic photovoltaic cells – promising indoor light harvesters for self-sustainable electronics
Authors: Lee Harrison Ka Hin , Wu Jiaying , Barbé Jérémy , Jain Sagar M. , Wood Sebastian , Speller Emily M. , Li Zhe , Castro Fernando A. , Durrant James R. , Tsoi Wing Chung
Published: December 2017

Organic photovoltaic (OPV) cells using BTR:PC71BM show promising power conversion efficiency of >28% under 1000 lux generating 78.2 μW cm−2, outperforming Si based PV cells and comparable to GaAs PV cells. This result suggests that OPV cells have excellent potential for indoor applications.
Nano-functionalized long-period fiber grating probe for disease-specific protein detection
Authors: Tyagi Deependra , Mishra Satyendra Kumar , Zou Bing , Lin Congcong , Hao Ting , Zhang Ge , Lu Aiping , Chiang Kin Seng , Yang Zhijun
Published: December 2017

Label-free nano-functionalized LPFG based real-time, reusable sensor for sensitive detection of disease-specific proteins.
A novel self-assembled pH-sensitive targeted nanoparticle platform based on antibody–4arm-polyethylene glycol–pterostilbene conjugates for co-delivery of anticancer drugs
Authors: Liu Ke-Feng , Liu Yan-Xue , Dai Lin , Li Chun-Xiao , Wang Luying , Liu Jing , Lei Jian-Du
Published: December 2017

Recently, antibody–drug conjugates (ADC) have shown potential for cancer immunotherapy by tumor-targeted delivery of anticancer drugs.
Efficient non-doped yellow OLEDs based on thermally activated delayed fluorescence conjugated polymers with an acridine/carbazole donor backbone and triphenyltriazine acceptor pendant
Authors: Wang Yanjie , Zhu Yunhui , Lin Xingdong , Yang Yike , Zhang Baohua , Zhan Hongmei , Xie Zhiyuan , Cheng Yanxiang
Published: December 2017

Non-doped OLEDs employing TADF conjugated polymers exhibit excellent electroluminescent performances.
One step facile synthesis of a novel anthanthrone dye-based, dopant-free hole transporting material for efficient and stable perovskite solar cells
Authors: Pham Hong Duc , Hayasake Kazuma , Kim Jinhyun , Do Thu Trang , Matsui Hiroyuki , Manzhos Sergei , Feron Krishna , Tokito Shizuo , Watson Trystan , Tsoi Wing Chung , Motta Nunzio , Durrant James R. , Jain Sagar Motilal , Sonar Prashant
Published: December 2017

A new dopant free stable HTM using anthanthrone dye has been reported with 11.5% efficiency.
The role of radical prostatectomy for the treatment of metastatic prostate cancer: a systematic review and meta-analysis
Authors: Wang Yi , Qin Zhiqiang , Wang Yamin , Chen Chen , Wang Yichun , Meng Xianghu , Song Ninghong
Published: December 2017

The recommended therapy by EAU guidelines for metastatic prostate cancer (mPCa) is androgen deprivation therapy (ADT) with or without chemotherapy. The role of radical prostatectomy (RP) in the treatment of mPCa is still controversial. Hence, a meta-analysis was conducted by comprehensively searching the databases PubMed, EMBASE and Web of Science for the relevant studies published before September 1st, 2017. Our results successfully shed light on the relationship that RP for mPCa was associated with decreased cancer-specific mortality (CSM) (pooled HR = 0.41, 95%CI = 0.36–0.47) and enhanced overall survival (OS) (pooled HR = 0.49, 95%CI = 0.44–0.55). Subsequent stratified analysis demonstrated that no matter how RP compared with no local therapy (NLT) or radiation therapy (RT), it was linked to a lower CSM (pooled HR = 0.36, 95%CI = 0.30–0.43 and pooled HR = 0.56, 95%CI 0.43–0.73, respectively) and a higher OS (pooled HR = 0.49, 95%CI = 0.44–0.56 and pooled HR = 0.46, 95%CI 0.33–0.65, separately). When comparing different levels of Gleason score, M-stage or N-stage, our results indicated that high level of Gleason score, M-stage or N-stage was associated with increased CSM. In summary, the outcomes of the present meta-analysis demonstrated that RP for mPCa was correlated with decreased CSM and enhanced OS in eligible patients of involved studies. In addition, patients with less aggressive tumors and good general health seemed to benefit the most. Moreover, no matter compared with NLT or RT, RP showed significant superiority in OS or CSM. Upcoming prospective randomized controlled trials were warranted to provide more high-quality data.
Visualizing the Consistency of Thickened Liquids With Simple Tools: Implications for Clinical Practice
Authors: Mertz Garcia Jane , Chambers Edgar , Cook Kelsey
Published: December 2017

Purpose

Accurate texture modifications to thin liquids are a critical aspect of patients' nutritional health and well-being. This study explored the use of 3 tools (2 distance- and 1 time-measuring devices) to characterize texture-modified liquids. The objectives were to use the tools to measure modified liquids, to determine if measurements differentiated nectar and honey levels of modification, and to compare measurements with other published reports.

Method

We measured the flow distance of 33 prethickened water samples in centimeters (cm) using a line spread apparatus and a Bostwick Consistometer (Christison Particle Technologies). We selected a Zahn viscosity cup to measure the stream time of each prethickened liquid in seconds.

Results

The 2 distance-measuring devices (line spread and Bostwick Consistometer) showed that thinner (nectar-thick) modifications spread or flowed a farther distance in comparison to thicker (honey-like) modifications. Testing with the line spread indicated that an average spread distance of 4.5 cm differentiated nectar-thick and honey-like consistencies. A flow distance of greater than 15 cm differentiated nectar from honey consistency measured with a Bostwick Consistometer. We were not successful in using the Zahn viscosity cup to determine the stream time of modified liquids.

Conclusions

Two of the tools provided objective information about levels of liquid modification, which has implications for day-to-day preparation. Measurement tools that are accurate and easy to use have the potential to provide quick and dependable feedback to verify a prescribed level of liquid modification. Further efforts are needed to standardize the application of simple measurement tools in the management of patients who consume thickened liquids.
Preparation of Speech-Language Pathologists to Work With English Learners (ELs): Incorporating Interprofessional Education (IPE) and Interprofessional Collaborative Practice (IPP) Competencies
Authors: Rosa-Lugo Linda I. , Mihai Florin M. , Nutta Joyce W.
Published: December 2017

Speech-language pathologists (SLPs) are required to acquire critical knowledge, skills, and clinical experience to serve English learners (ELs) in school settings with disabilities in language, learning, and literacy. To provide students with appropriate academic and clinical preparation, three colleges at the University of Central Florida (Health & Public Affairs, Education and Human Performance, and Arts and Humanities) collaborated to create a new interdisciplinary specialization in school speech-language pathology. This specialization focused on English Speakers of Other Languages (ESOL) standards and competencies to address the needs of ELs and provide educationally relevant experiences for students. Interprofessional education (IPE) and collaborative practice (IPP) frameworks guided the development of clinically oriented academic coursework and internships to prepare SLPs to integrate evidenced-based training with practice. This qualitative study examined the perceptions of 40 graduate students, who participated in a personnel preparation program focused on preparing SLPs to work with ELs and ELs with a communication disorder.
Small Steps Towards a Speech Therapy Profession in Cambodia: Lessons Learned So Far
Authors: Salter Claire , Yeoh Weh
Published: December 2017

This paper provides a contemporary overview of speech language pathology services and professional training in Cambodia. The unique national context, including Cambodia's conflict-ridden past, its resource-poor and underdeveloped health sector institutions, and the proliferation of many international non-governmental organizations (NGOs) operating in the country, all serve to make the delivery of speech-language pathology services and establishment of a local speech-language pathology profession challenging and complex. The increasing numbers of international speech-language pathology professionals volunteering their services on a short-term basis in Cambodia is given focus, and the subsequent impact on establishing sustainable local services. We profile the efforts of one NGO, OIC Cambodia, and its “Exit Strategy,” aimed at developing a local speech-language pathology professional infrastructure through local training, a more robust Cambodian government policy framework, establishing local career pathways and professional network, and public awareness raising of speech-language pathology needs and services. The paper concludes that there will be more significant and ongoing benefits for the Cambodian health and education sectors and general population by focussing efforts on establishing a local speech-language pathology profession and institutional presence.
Intratumoral Bleeding in a Vestibular Schwannoma
Authors: Braga Emanuelle , Köhler Luiza , de Cesaro Marcelo , Barreto Tasso , Giacomelli Richard , Azambuja Jr Nério , Varela Daniel , Mesquita Filho Paulo
Published: December 2017

Vestibular schwannomas (VSs) account for ∼ 70% of all tumors of the cerebellopontine angle (CPA). Their clinical presentation is often insidious, with progressive hearing loss and involvement of other cranial nerves. Spontaneous hemorrhage in those tumors is very unusual, and generally presents with acute clinical features such as nausea, vomiting, headache and altered consciousness, usually with marked dysfunction of the cranial nerve involved, and with new deficits of neighboring cranial nerves. Asymptomatic patients are extremely rare. We present a case report of an incidental VS with asymptomatic bleeding, which evolved to death after surgery.
Gesundheits-Apps: Wie kann eine Zertifizierung konkret aussehen?
Authors: Kramer Ursula
Published: December 2017

Ob beim Ärztetag in Freiburg, dem Digitalgipfel in Ludwigshafen oder in jüngsten Positionspapieren der Kassenärztlichen Bundesvereinigung (KBV): Die Forderung nach Konzepten, die im Dickicht der digitalen Gesundheitsanwendungen über Qualität, Risiken und Nutzen von Gesundheits-Apps Orientierung geben sollen, wird lauter. Erfahrungen mit App-Empfehlungsplattformen, die sich national und weltweit entwickelt haben, zeigen, dass der erforderliche Prüfaufwand hoch ist, das Risiko von Gesundheits-Apps erheblich variieren kann und das Vertrauen in App-Empfehlungen schnell verspielt ist. Um die erhoffte Orientierung zu vermitteln, braucht ein Qualitätssiegel für Gesundheits- und Medizin-Apps vor allem eines: eine hohe Sichtbarkeit und Akzeptanz bei Nutzern und Therapeuten gleichermaßen. Aus den Erfahrungen mit App-Bewertungsportalen hier und anderswo lässt sich ableiten, wie eine App-Zertifizierung in Zukunft konkret aussehen könnte.
Mit E-Health Kosten sparen
Authors: van de Sand Lasse , Schildt Janko , Bosse Mathias , Neukirch Benno , Thun Sylvia
Published: December 2017

Das Krankheitsbild des Diabetes mellitus besitzt eine immense gesundheitspolitische und gesellschaftliche Relevanz. Im Jahr 2008 sind nach Angaben des statistischen Bundesamts für die Versorgung von Menschen mit Diabetes direkte Kosten von insgesamt 6,34 Milliarden Euro durch Medikamente, ambulante und stationäre Behandlung, Pflege- und Rehabilitationsleistungen aufgelaufen. Dies entspricht einem Anteil von 2,5 % der Gesundheitsausgaben aller Krankheiten. Lässt sich jedoch der HbA1c-Wert nachhaltig senken – beispielsweise über einen telemedizinischen Ansatz von 9,0 auf 7,0 % – ergibt sich, gemessen zwischen dem 41. und dem 95. Lebensjahr, anhand einer Markov-Modellierung pro Person und Zyklus ein maximales mittleres Einsparpotenzial von 579,14 Euro pro Patient. Seine maximale Ausprägung erreicht das Einsparpotenzial jedoch bei an Diabetes erkrankten Menschen zwischen dem 41. und dem 61. Lebensjahr: In dieser Zeitspanne lassen sich im Mittel 921,13 Euro pro Person und vorab definiertem Zyklus einsparen, wenn es gelingt, den HbA1c-Wert dauerhaft von 8,0 auf 6,0 % zu senken. In späteren Lebensaltern gleichen sich die Kostenverläufe zwischen niedrigen und hohen HbA1c-Werten allerdings zunehmend an. Da jedoch diverse diabetische Folgeerkrankungen sowie relevante Kostenbestandteile aufgrund einer eingeschränkten Datenlage außerhalb der durchgeführten Analysen verbleiben, liegen die errechneten Einsparpotenziale voraussichtlich unterhalb der real erzielbaren.
Update Breast Cancer 2017 – Implementation of Novel Therapies
Authors: Lux Michael , Janni Wolfgang , Hartkopf Andreas , Nabieva Naiba , Taran Florin-Andrei , Overkamp Friedrich , Kolberg Hans-Christian , Hadji Peyman , Tesch Hans , Ettl Johannes , Huober Jens , Lüftner Diana , Wallwiener Markus , Müller Volkmar , Beckmann Matthias , Belleville Erik , Fehm Tanja , Wallwiener Diethelm , Brucker Sara , Schneeweiss Andreas , Fasching Peter
Published: December 2017

In recent years, numerous new therapy options for patients with breast cancer have been developed in clinical studies, with some options already approved for routine treatment. As the speed at which innovations are introduced increases, the importance of conferences also increases, as conferences are where the data underpinning new therapies are usually presented for the first time. This review looks at publications of the ASCO (American Society of Clinical Oncology) and ESMO (European Society of Medical Oncology) conferences in 2017, summarizes them and evaluates them in the context of existing data. The focus is on new insights for neoadjuvant therapy and new treatment options in the metastatic setting, such as the use of CDK4/6 inhibitors or PARP inhibitors. The first results of treatments with checkpoint inhibitors are presented. With the patent expiry of trastuzumab, a number of study results for trastuzumab biosimilars have also been published. The digitization of patient care provides the first results on quality of life and prognosis of patients with advanced cancer. Digital communications between patients and physicians are being evaluated in several studies in Germany. As the discussion about patient-relevant endpoints for patients in the metastatic setting continues, overall survival rates from studies of big endocrine-based therapies are urgently needed. Preliminary analyses of small study cohorts offer initial insights. In the context of improving patient care, in the coming years, questions will center on which patients particularly benefit from certain therapies and which patients need particular protection from specific side effects. Questions about these predictors are raised in many scientific projects as attention increasingly focuses on this topic.
Connecting structurally and dynamically detected signatures of supramolecular Debye liquids
Authors: Büning T. , Lueg J. , Bolle J. , Sternemann C. , Gainaru C. , Tolan M. , Böhmer R.
Published: December 2017

The monohydroxy alcohol 2-ethyl-1-hexanol mixed with the halogen-substituted alkyl halides 2-ethyl-1-hexyl chloride and 2-ethyl-1-hexyl bromide was studied using synchrotron-based x-ray scattering. In the diffraction patterns, an oxygen-related prepeak appears. The concentration dependence of its intensity, shape, and position indicates that the formation of the hydrogen-bonded associates of monohydroxy alcohols is largely hindered by the halogen alkane admixture. Using dielectric spectroscopy and high-resolution rheology on the same liquid mixtures, it is shown that these structural features are correlated with the relaxation mechanisms giving rise to supramolecular low-frequency dynamics.
Efficiency in knowledge transmission in R&D project networks: European renewable energy sector
Authors: Larruscain Jaso , Río-Belver Rosa , Arraibi Juan Ramón , Garechana Gaizka
Published: December 2017

This study analyses the efficiency in knowledge transmission of organizations and local regions participating in European R&D projects in 2000–2013 within renewable energy (RE) sectors (wind, solar, sea, geothermal, and biomass) using social network analysis (SNA). A review of the collaborative R&D consortium networks as technological transfer structures and public policy support issues was carried out. Then, not only is the traditional SNA centrality perspective of actors employed to identify key players who bridge less connected areas, but also the structural hole approach is applied based on the relative position, role, and potential redundancy of collaborations from the overall network perspective. It reveals that networks of organizations and local regions are neither completely random nor homogenous in terms of cohesion and efficiency. Additionally, the existence of areas between core and peripheral nodes (structural holes) is confirmed. Higher education and research centers, which show a greater influential position and higher experience, take advantage of them. Research concludes that the efficiency in terms of knowledge transmission is not always positively correlated with high centrality values. The most emergent RE sectors still appear less efficient according to the rankings produced integrating both approaches. This paper makes a novel academic contribution to RE policy makers since a new application of centrality and efficiency perspectives is applied. As a result, policy makers should consider it in detail when designing public RE projects with the aim of building an efficient European Research Area.
Chemical vapour deposition of freestanding sub-60 nm graphene gyroids
Authors: Cebo Tomasz , Aria Adrianus I. , Dolan James A. , Weatherup Robert S. , Nakanishi Kenichi , Kidambi Piran R. , Divitini Giorgio , Ducati Caterina , Steiner Ullrich , Hofmann Stephan
Published: December 2017

The direct chemical vapour deposition of freestanding graphene gyroids with controlled sub-60 nm unit cell sizes is demonstrated. Three-dimensional (3D) nickel templates were fabricated through electrodeposition into a selectively voided triblock terpolymer. The high temperature instability of sub-micron unit cell structures was effectively addressed through the early introduction of the carbon precursor, which stabilizes the metallized gyroidal templates. The as-grown graphene gyroids are self-supporting and can be transferred onto a variety of substrates. Furthermore, they represent the smallest free standing periodic graphene 3D structures yet produced with a pore size of tens of nm, as analysed by electron microscopy and optical spectroscopy. We discuss generality of our methodology for the synthesis of other types of nanoscale, 3D graphene assemblies, and the transferability of this approach to other 2D materials.
Long distance measurement up to 1.2 km by electro-optic dual-comb interferometry
Authors: Wu Hanzhong , Zhao Tuo , Wang Zhiyang , Zhang Kai , Xue Bin , Li Jianshuang , He Mingzhao , Qu Xinghua
Published: December 2017

We perform a long distance measurement up to 1.2 km on the outdoor baseline by electro-optic dual-comb interferometry. A frequency comb pair is developed by phase modulating a continuous laser with a narrow linewidth, and the slightly different repetition frequencies are synchronized to the Rb clock via the signal generators. A RF electrical comb can be generated by multi-wavelength heterodyne interferometry, and thus, a series of synthetic wavelengths can be obtained, whose phases can be used to determine the distances. Compared with the reference values, the experimental results show an agreement within 379 μm in the 1180 m range. In the long-time experiments, the Allan deviation can be below 20 μm with an averaging time of 10 s, and can be further improved to be less than 600 nm when the averaging time is above 350 s at 435 m and 1180 m, respectively.
Tsu-Esaki modeling of tunneling currents in ferroelectric tunnel junctions
Authors: Tuomisto Noora , van Dijken Sebastiaan , Puska Martti
Published: December 2017

We model tunneling currents through step barrier structures representative of ferroelectric tunnel junctions wherein one of the electrodes contributes to the barrier potential profile or an extra layer is grown between the ferroelectric barrier and one of the electrodes. We study current density–voltage (J–V) and tunneling electroresistance (TER) curves using the Tsu-Esaki formula with numerically calculated transmission. This method is computationally robust, and the same results cannot be obtained with the standard methods usually applied for interpreting experimental I–V curves. Our results predict that the effect of resonant tunneling produces asymmetry in the J–V curves and negative differential resistance characteristics. We show that the asymmetry of the J–V curves can be tuned by adjusting the barrier heights and widths and that changing the extra barrier width affects the asymmetry the most. The barrier widths and the main barrier height affect the magnitude of the tunneling current the most. The change in the tilt of the main barrier is suggested to produce a significant TER of the order of 102. Our numerical method provides a systematic way to study trends in tunneling currents through step barrier structures across a wide range of barrier parameters and bias voltages, in contrast to the necessity of employing several different approximations when using analytical formulae. Therefore, our method provides the means for interpreting existing and future experiments and can be used as a tool for designing new devices with desired functionalities.
UV detector based on InAlN/GaN-on-Si HEMT stack with photo-to-dark current ratio > 107
Authors: kumar Sandeep , Pratiyush Anamika Singh , Dolmanan Surani B. , Tripathy Sudhiranjan , Muralidharan Rangarajan , Nath Digbijoy N.
Published: December 2017

We demonstrate an InAlN/GaN-on-Si high electron mobility transistor based UV detector with a photo-to-dark current ratio of  >107. The Ti/Al/Ni/Au metal stack was evaporated and thermal annealed rapidly for Ohmic contacts to the 2D electron gas (2DEG) at the InAlN/GaN interface, while the channel + barrier was recess etched to a depth of 20 nm to pinch-off the 2DEG between Source-Drain pads. A spectral responsivity (SR) of 32.9 A/W at 367 nm was measured at 5 V. A very high photo-to-dark current ratio of >107 was measured at a bias of 20 V. The photo-to-dark current ratio at a fixed bias was found to be decreasing with an increase in the recess length of photodetectors. The fabricated devices were found to exhibit a UV-to-visible rejection ratio of >103 with a low dark current of < 32 pA at 5 V. Transient measurements showed rise and fall times in the range of 3–4 ms. The gain mechanism was investigated, and carrier lifetimes were estimated which matched well with those reported elsewhere.
Large-scale broadband absorber based on metallic tungsten nanocone structure
Authors: Wang Jiaxing , Liang Yuzhang , Huo Pengcheng , Wang Daopeng , Tan Jun , Xu Ting
Published: December 2017

We report a broadband tungsten absorber based on a nanocone metallic resonant structure fabricated by self-assembly nanosphere lithography. In experimental demonstration, the fabricated absorber has more than 90% average absorption efficiency and shows superior angular tolerance in the entire visible and near-infrared spectral region. We envision that this large-scale nanostructured broadband optical absorber would find great potential in the applications of high performance optoelectronic platforms and solar-thermal energy harvesting systems.
Nonperturbative response functions: A tool for the interpretation of four-wave-mixing signals beyond third order
Authors: Chen Lipeng , Palacino-González Elisa , Gelin Maxim F. , Domcke Wolfgang
Published: December 2017

Considering an electronic two-level system coupled to vibrational degrees of freedom and driven by short and intense non-overlapping laser pulses, we introduce the concept of nonperturbative response functions. These response functions are expressed in terms of effective electronic transition dipole moments which depend on the strength of the field-matter coupling and on the pulse durations. It is shown that the nonlinear polarization representing four-wave-mixing signals can elegantly be expressed in terms of these nonperturbative response functions to all orders in the field-matter coupling. The nonperturbative response functions generalize the interpretative power of the familiar third-order response functions to four-wave-mixing experiments with intense laser pulses.
Lowering of acoustic droplet vaporization threshold via aggregation
Authors: Guo Shifang , Shi Aiwei , Xu Shanshan , Du Xuan , Wang Xin , Zong Yujin , Bouakaz Ayache , Wan Mingxi
Published: December 2017

Acoustically sensitive emulsion nanodroplets composed of perfluorocarbon have shown great potential for advanced medical diagnosis and therapy but are limited by the required high acoustic droplet vaporization (ADV) threshold for clinical applications. This study investigates the use of an ultrasonic standing wave to lower the ADV threshold while maintaining the generated bubble size in the required size range, ensuring the generation of inertial cavitation and corresponding physical effects. The results showed that disperse nanodroplets were manipulated to form micron-sized aggregations, and the required ADV threshold was significantly lowered, while a similar size range of the microbubbles generated by disperse nanodroplets was maintained. The threshold could be further regulated by adjusting the aggregation size via controlling the concentration of the disperse nanodroplets. Furthermore, the internal pressures in the aggregations with different sizes were calculated to determine their ADV thresholds theoretically, which were shown to be in good agreement with the experimental results.
Strain-mediated magnetic response in La0.67Sr0.33MnO3/SrTiO3/La0.67Sr0.33MnO3/BaTiO3 structure
Authors: Swain Anupama , Komatsu Katsuyoshi , Itoh Mitsuru , Taniyama Tomoyasu , Gorige Venkataiah
Published: December 2017

Electric field controlled magnetism is an exciting area of condensed matter physics to explore the device applications at ultra-low power consumption compared to the conventional current controlled or magnetic field controlled devices. In this study, an attempt was made to demonstrate electric field controlled magnetoresistance (MR) in a tri-layer structure consisting of La0.67Sr0.33MnO3 (LSMO) (40 nm)/SrTiO3 (10 nm)/LSMO (10 nm) grown on a 500-μm-thick BaTiO3 (001) (BTO) single crystal substrate by pulsed laser deposition technique. Epitaxial growth of the trilayer structure was confirmed by x-ray diffraction measurements. Jumps observed in the temperature-dependent magnetization curve at around the structural phase transitions of BTO ensure the strain-mediated magnetoelectric coupling between LSMO and BTO layers. A significant change in MR of this structure in applied electric fields does not show any polarity dependence. The findings are related to the lattice strain-mediated magnetoelectric coupling in ferromagnetic LSMO/ferroelectric BTO heterostructures.
Stacking fault density and bond orientational order of fcc ruthenium nanoparticles
Authors: Seo Okkyun , Sakata Osami , Kim Jae Myung , Hiroi Satoshi , Song Chulho , Kumara Loku Singgappulige Rosantha , Ohara Koji , Dekura Shun , Kusada Kohei , Kobayashi Hirokazu , Kitagawa Hiroshi
Published: December 2017

We investigated crystal structure deviations of catalytic nanoparticles (NPs) using synchrotron powder X-ray diffraction. The samples were fcc ruthenium (Ru) NPs with diameters of 2.4, 3.5, 3.9, and 5.4 nm. We analyzed average crystal structures by applying the line profile method to a stacking fault model and local crystal structures using bond orientational order (BOO) parameters. The reflection peaks shifted depending on rules that apply to each stacking fault. We evaluated the quantitative stacking faults densities for fcc Ru NPs, and the stacking fault per number of layers was 2–4, which is quite large. Our analysis shows that the fcc Ru 2.4 nm-diameter NPs have a considerably high stacking fault density. The B factor tends to increase with the increasing stacking fault density. A structural parameter that we define from the BOO parameters exhibits a significant difference from the ideal value of the fcc structure. This indicates that the fcc Ru NPs are highly disordered.