bluuebunny/crossref_metadata_2025 huggingface dataset:
Concurrent Aerobic and Resistance Training Has Anti‐Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF‐1 in Late Middle‐Aged Type 2 Diabetic Patients
Authors: Annibalini Giosuè , Lucertini Francesco , Agostini Deborah , Vallorani Luciana , Gioacchini Annamaria , Barbieri Elena , Guescini Michele , Casadei Lucia , Passalia Annunziata , Del Sal Marta , Piccoli Giovanni , Andreani Mauro , Federici Ario , Stocchi Vilberto
Published: June 2017

Type 2 diabetes (T2D) is an age‐related chronic disease associated with metabolic dysregulation, chronic inflammation, and activation of peripheral blood mononuclear cells (PBMC). The aim of this study was to assess the effects of a concurrent exercise training program on inflammatory status and metabolic parameters of T2D patients. Sixteen male patients (age range 55–70) were randomly assigned to an intervention group (n = 8), which underwent a concurrent aerobic and resistance training program (3 times a week; 16 weeks), or to a control group, which followed physicians’ usual diabetes care advices. Training intervention significantly improved patients’ body composition, blood pressure, total cholesterol, and overall fitness level. After training, plasma levels of adipokines leptin (−33.9%) and RBP4 (−21.3%), and proinflammatory markers IL‐6 (−25.3%), TNF‐α (−19.8%) and MCP‐1 (−15.3%) decreased, whereas anabolic hormone IGF‐1 level increased (+16.4%). All improvements were significantly greater than those of control patients. Plasma proteomic profile of exercised patients showed a reduction of immunoglobulin K light chain and fibrinogen as well. Training also induced a modulation of IL-6, IGF-1, and IGFBP-3 mRNAs in the PBMCs. These findings confirm that concurrent aerobic and resistance training improves T2D‐related metabolic abnormalities and has the potential to reduce the deleterious health effects of diabetes‐related inflammation.
Primary Osteosarcoma of the Breast Arising in an Intraductal Papilloma
Authors: Alghofaily Khalefa Ali , Almushayqih Musab Hamoud , Alanazi Muhannad Faleh , Salamah Abdullah Abdulrahman Bin , Benediktsson Halldor
Published: June 2017

Introduction. Primary osteosarcoma of the breast is extremely rare, and an osteosarcoma arising from an intraductal papilloma is exceptional. Case Presentation. A 72-year-old Saudi Arabian woman presented with a solid, bone-containing breast mass that was diagnosed as primary osteosarcoma of the breast on biopsy. She had a history of untreated intraductal papilloma. Treatment was completed with a modified mastectomy after excluding extramammary metastases. However, she subsequently developed multiple recurrent lesions at the same site. Conclusion. Primary osteogenic sarcomas of the breast are very rare. Although the main treatment is resection the optimal management remains uncertain and prognosis is poor.
SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation
Authors: Denu Ryan A.
Published: June 2017

Mesenchymal stem cells (MSCs) are multipotent cells that are currently being investigated in a wide variety of clinical trials for their anti‐inflammatory and immunomodulatory properties as well as their osteogenic and chondrogenic capabilities. However, there are considerable interdonor variability and heterogeneity of MSC populations, making it challenging to compare different products. Furthermore, proliferation, differentiation, and immunomodulation of MSCs decrease with aging and ex vivo expansion. The sirtuins have emerged as a class of protein deacylases involved in aging, oxidative stress, and metabolism. Sirtuin 3 (SIRT3) is the major mitochondrial deacetylase involved in reducing oxidative stress while preserving oxidative metabolism, and its levels have been shown to decrease with age. This study investigated the role of SIRT3 in MSC differentiation and aging. As MSCs were expanded ex vivo, SIRT3 levels decreased. In addition, SIRT3 depletion reduced MSC differentiation into adipocytes and osteoblasts. Furthermore, overexpression of SIRT3 in later‐passage MSCs reduced aging‐related senescence, reduced oxidative stress, and enhanced their ability to differentiate. These data suggest that overexpressing SIRT3 might represent a strategy to increase the quality and quantity of MSCs utilized for clinical applications.
Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence
Authors: Yu Long-jie , Zhang Ke-Jian , Zhu Jia-Zhen , Zheng Qun , Bao Xiao-Yi , Thapa Saroj , Wang Yan , Chu Mao-Ping
Published: June 2017

Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds. Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen. Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction. Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016. The outcome measures were vascular endothelium growth factor (VEGF), blood vessel density (BVD), and myocardial infarct size. All the data were analyzed using Rev‐Man 5.3 software. Ultimately, 14 studies were identified involving 226 animals. The quality score of studies ranged from 3 to 6. The meta‐analysis of six studies showed significant effects of salvianolic acid on increasing VEGF expression compared with the control group (P < 0.01). The meta‐analysis of the two salvianolic acid A studies and three salvianolic acid B studies showed significantly improving BVD compared with the control group (P < 0.01). The meta‐analysis of five studies showed significant effects of salvianolic acid for decreasing myocardial infarct size compared with the control group (P < 0.01). In conclusion, these findings demonstrated that salvianolic acid can exert cardioprotection through promoting angiogenesis in animal models of myocardial infarction.
Intra-Articular Injection of Human Synovial Membrane-Derived Mesenchymal Stem Cells in Murine Collagen-Induced Arthritis: Assessment of Immunomodulatory Capacity In Vivo
Authors: Yan Minglu , Liu Xin , Dang Qiujie , Huang He , Yang Fan , Li Yang
Published: June 2017

The aim of this study was to evaluate the efficacy of human synovial membrane-derived MSCs (SM-MSCs) in murine collagen-induced arthritis (CIA). Male mice (age 7–9 weeks) were injected intra-articularly with SM-MSCs obtained from patients with osteoarthritis, on days 28, 32, and 38 after bovine type II collagen immunization. The efficacy of SM-MSCs in CIA was evaluated clinically and histologically. Cytokine profile analyses were performed by real-time polymerase chain reaction and multiplex analyses. Splenic helper T (Th) cell and regulatory B cell subsets were analyzed by flow cytometry.Intra-articular SM-MSC injection ameliorated the clinical and histological severity of arthritis. Decrease in tumor necrosis factor-α, interferon-γ, and interleukin- (IL-) 17A and increase in IL-10 production were observed after SM-MSC treatment. Flow cytometry showed that Th1 and Th17 cells decreased, whereas Th2, regulatory T (Treg), and PD-1+CXCR5+FoxP3+follicular Treg cells increased in the spleens of SM-MSC-treated mice. Regulatory B cell analysis showed that CD21hiCD23hitransitional 2 cells, CD23lowCD21himarginal zone cells, and CD19+CD5+CD1d+IL-10+regulatory B cells increased following SM-MSC treatment. Our results demonstrated that SM-MSCs injected in inflamed joints in CIA had a therapeutic effect and could prevent arthritis development and suppress immune responses via immunoregulatory cell expansion.
The false click beetles (Coleoptera: Eucnemidae) of Hawai'i
Authors: OTTO ROBERT L.
Published: June 2017

The Hawaiian eucnemid fauna is reviewed. Each of the known species is redescribed along with descriptions of 20 new species. An overview of the distribution as well as any known aspects of natural history are provided for each species, and keys to identify the Hawaiian species are provided. The following 20 new taxa are described: Fornax muonai new species (type locality Hawai'i), Fornax swezeyi new species (Maui), Fornax yoshimotoi new species (Kaua'i), Dromaeolus acaciakoa new species (Kaua'i), Dromaeolus breviangularis new species (Kaua'i), Dromaeolus forbesi new species (Kaua'i), Dromaeolus halehakuensis new species (Maui), Dromaeolus hardyi new species (Maui), Dromaeolus harryi new species (Kaua'i), Dromaeolus kokeensis new species (Kaua'i) Dromaeolus leroyi new species (Kaua'i), Dromaeolus nualoloensis new species (Kaua'i), Dromaeolus oahuensis new species (O'ahu), Dromaeolus paulayi new species (Kaua'i), Dromaeolus ruffini new species (Hawai'i), Dromaeolus sandrae new species (Maui), Dromaeolus susanae new species (Kaua'i), Dromaeolus waikapuensis new species (Maui), Dromaeolus youngi new species (Kaua'i) and Dromaeolus zimmermani new species (Kaua'i). Dromaeolus pachyderes var. kauaiensis Sharp is elevated to D. kauaiensis Sharp, new status. Each species is illustrated with a dorsal habitus image and accompanied by a distribution map.
Regionally Resolved Diagnostic of Transport: A Simplified Forward Model for CO2
Authors: Konopka Paul , Ploeger Felix , Tao Mengchu , Riese Martin
Published: June 2017

Simply diagnostic tools are useful for understanding transport processes in complex chemistry transport models (CTMs). For this purpose, a combined use of the airmass origin fractions (AOFs) and regionally resolved mean ages (RMAs) is presented. This approach merges the concept of the origin of air with the well-known theory of the mean age of air (AoA) for different regions covering the whole Earth. The authors show how the AoA calculated relative to Earth’s surface can be decomposed into regionally resolved components (i.e., into RMAs). Using both AOFs and RMAs, the authors discuss differences in the seasonality of transport from the Northern and Southern Hemispheres into the tropical tropopause layer (TTL), the asymmetries of the interhemispheric exchange, and differences in relation to the continental or oceanic origin of air. Furthermore, a simplified transport model for a chemically passive species (tracer) is formulated that has some potential to approximate the full transport within a CTM. This analytic approach uses the AOFs as well as the RMAs as parameters to propagate a tracer prescribed on Earth’s surface (lower boundary condition). This method is exactly valid for sources that change linearly with time in each of the considered regions. The authors analyze how well this approach approximates the propagation of CO2 from the planetary boundary layer (PBL) into the whole atmosphere. The CO2 values in the PBL are specified by the CarbonTracker dataset. The authors discuss how this approach can be used for inverse modeling of CO2.
Sensitivity of Gravity Wave Fluxes to Interannual Variations in Tropical Convection and Zonal Wind
Authors: Alexander M. Joan , Ortland David A. , Grimsdell Alison W. , Kim Ji-Eun
Published: June 2017

Using an idealized model framework with high-frequency tropical latent heating variability derived from global satellite observations of precipitation and clouds, the authors examine the properties and effects of gravity waves in the lower stratosphere, contrasting conditions in an El Niño year and a La Niña year. The model generates a broad spectrum of tropical waves including planetary-scale waves through mesoscale gravity waves. The authors compare modeled monthly mean regional variations in wind and temperature with reanalyses and validate the modeled gravity waves using satellite- and balloon-based estimates of gravity wave momentum flux. Some interesting changes in the gravity spectrum of momentum flux are found in the model, which are discussed in terms of the interannual variations in clouds, precipitation, and large-scale winds. While regional variations in clouds, precipitation, and winds are dramatic, the mean gravity wave zonal momentum fluxes entering the stratosphere differ by only 11%. The modeled intermittency in gravity wave momentum flux is shown to be very realistic compared to observations, and the largest-amplitude waves are related to significant gravity wave drag forces in the lowermost stratosphere. This strong intermittency is generally absent or weak in climate models because of deficiencies in parameterizations of gravity wave intermittency. These results suggest a way forward to improve model representations of the lowermost stratospheric quasi-biennial oscillation winds and teleconnections.
The Influence of Autumnal Eurasian Snow Cover on Climate and Its Link with Arctic Sea Ice Cover
Authors: Gastineau Guillaume , García-Serrano Javier , Frankignoul Claude
Published: June 2017

The relationship between Eurasian snow cover extent (SCE) and Northern Hemisphere atmospheric circulation is studied in reanalysis during 1979–2014 and in CMIP5 preindustrial control runs. In observations, dipolar SCE anomalies in November, with negative anomalies over eastern Europe and positive anomalies over eastern Siberia, are followed by a negative phase of the Arctic Oscillation (AO) one and two months later. In models, this effect is largely underestimated, but four models simulate such a relationship. In observations and these models, the SCE influence is primarily due to the eastern Siberian pole, which is itself driven by the Scandinavian pattern (SCA), with a large anticyclonic anomaly over the Urals. The SCA is also responsible for a link between Eurasian SCE anomalies and sea ice concentration (SIC) anomalies in the Barents–Kara Sea.

Increasing SCE over Siberia leads to a local cooling of the lower troposphere and is associated with warm conditions over the eastern Arctic. This is followed by a polar vortex weakening in December and January, which has an AO-like signature. In observations, the association between November SCE and the winter AO is amplified by SIC anomalies in the Barents–Kara Sea, where large diabatic heating of the lower troposphere occurs, but results suggest that the SCE is the main driver of the AO. Conversely, the sea ice anomalies have little influence in most models, which is consistent with the different SCA variability, the colder mean state, and the underestimation of troposphere–stratosphere coupling simulated in these models.
The effect of focused instruction on young children’s singing accuracy
Authors: Demorest Steven , Nichols Bryan , Pfordresher Peter Q.
Published: June 2017

The purpose of this study was to test the effect of daily singing instruction on the singing accuracy of young children and whether accuracy differed across four singing tasks. In a pretest-posttest design over seven months we compared the singing accuracy of kindergarteners in a school receiving daily singing instruction from a music specialist to a control school receiving no curricular music instruction. All children completed four singing tasks at the beginning and end of the study: matching single pitches, matching intervals, matching short patterns, and singing a familiar song from memory. We found that both groups showed improvement on the pitch-matching tasks from pretest to posttest, but the experimental group demonstrated significantly more improvement. Performance on the familiar song task did not improve for either group. Students achieved the highest accuracy scores when matching intervals. Regular singing instruction seems to accelerate the development of accurate singing for young children, but the improvement was evident only in the pitch-matching tasks. It is possible that singing skill development proceeds from pitch-matching to the more difficult task of singing a song from memory. If so, this has implications for how we structure singing instruction in the early grades.
Academic Correlates of Unwanted Sexual Contact, Intercourse, Stalking, and Intimate Partner Violence: An Understudied but Important Consequence for College Students
Authors: Banyard Victoria L. , Demers Jennifer M. , Cohn Ellen S. , Edwards Katie M. , Moynihan Mary M. , Walsh Wendy A. , Ward Sally K.
Published: June 2017

Sexual assault, partner abuse, and stalking are major problems on college campuses. Past research has demonstrated a host of physiological and psychological outcomes associated with victimization; however, there has been little research conducted on the potential academic outcomes associated with victimization. The purpose of this study was to measure the relation between academic outcomes and experiences of sexual violence, intimate partner violence, and stalking victimization among college students. A sample of 6,482 undergraduate students currently enrolled at one of eight universities in New England was surveyed using items from the subscales of the College Persistence Questionnaire (Academic Efficacy, Collegiate Stress, Institutional Commitment, and Scholastic Conscientiousness). All four types of victimization were associated with significant differences on academic outcomes after controlling for sex and year in school, with victimized students reporting lower academic efficacy, higher college-related stress, lower institutional commitment, and lower scholastic conscientiousness. Polyvictimization was also significantly correlated with outcomes, with the greater number of types of victimization experienced by students being associated with more negative academic outcomes. Implications for future research and campus response were discussed.
Preserving Employee Privacy in Wellness
Authors: Terry Paul E.
Published: June 2017

The proposed “Preserving Employee Wellness Programs Act” states that the collection of information about the manifested disease or disorder of a family member shall not be considered an unlawful acquisition of genetic information. The bill recognizes employee privacy protections that are already in place and includes specific language relating to nondiscrimination based on illness. Why did legislation expressly intending to “preserve wellness programs” generate such antipathy about wellness among journalists? This article argues that those who are committed to preserving employee wellness must be equally committed to preserving employee privacy. Related to this, we should better parse between discussions and rules about commonplace health screenings versus much less common genetic testing.
Adjusting State Public School Teacher Salaries for Interstate Comparison
Authors: Rickman Dan S. , Wang Hongbo , Winters John V.
Published: June 2017

Using the three-year microdata sample of the American Community Survey for 2009 to 2011, we compute public school teacher salaries for comparison across US states. Teacher salaries are adjusted for state differences in teacher characteristics, cost of living, federal tax rates, household amenity attractiveness, and location within the metropolitan versus nonmetropolitan portions of the states. We find high persistence in the state rankings of nominal public school teacher salaries across time. Yet, we also find that the rankings significantly shift with the adjustments, suggesting they are necessary for meaningful comparisons of public teacher salaries across states. The differences in teacher pay across states also greatly narrow with the adjustments. Finally, this is the first study to show and test that teacher salary comparisons across states should be based on a comparison of public school teacher salaries with nonteacher college graduates in the states, adjusted for differences in personal characteristics and effective federal tax rates.
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease
Authors: Mastaglio Sara , Genovese Pietro , Magnani Zulma , Ruggiero Eliana , Landoni Elisa , Camisa Barbara , Schiroli Giulia , Provasi Elena , Lombardo Angelo , Reik Andreas , Cieri Nicoletta , Rocchi Martina , Oliveira Giacomo , Escobar Giulia , Casucci Monica , Gentner Bernhard , Spinelli Antonello , Mondino Anna , Bondanza Attilio , Vago Luca , Ponzoni Maurilio , Ciceri Fabio , Holmes Michael C. , Naldini Luigi , Bonini Chiara
Published: June 2017

Key Points

TCR SE is a clinically feasible approach to rapidly produce highly performing and specific tumor reactive T cells. NY-ESO-1 TCR SE T cells kill multiple myeloma in the absence of off-target reactivity including alloreactivity.
Physiologic Considerations in Trauma Patients Undergoing Resuscitative Endovascular Balloon Occlusion of the Aorta
Authors: Qasim Zaffer A. , Sikorski Robert A.
Published: June 2017

Resuscitative endovascular balloon occlusion of the aorta is a new procedure for adjunctive management of critically injured patients with noncompressible torso or pelvic hemorrhage who are in refractory hemorrhagic shock, ie, bleeding to death. The anesthesiologist plays a critical role in management of these patients, from initial evaluation in the trauma bay to definitive care in the operating room and the critical care unit. A comprehensive understanding of the effects of resuscitative endovascular balloon occlusion of the aorta is essential to making it an effective component of hemostatic resuscitation.
PhenoPlasm: a database of disruption phenotypes for malaria parasite genes
Authors: Sanderson Theo , Rayner Julian C.
Published: June 2017

Two decades after the first Plasmodium transfection, attempts have been made to disrupt more than 3,151 genes in malaria parasites, across five Plasmodium species. While results from rodent malaria transfections have been curated and systematised, empowering large-scale analysis, phenotypic data from human malaria parasite transfections currently exists as individual reports scattered across a the literature. To facilitate systematic analysis of published experimental genetic data across Plasmodium species, we have built PhenoPlasm (http://www.phenoplasm.org), a database of phenotypes generated by transfection experiments in all Plasmodium parasites. The site provides a simple interface linking citation-backed Plasmodium reverse-genetic phenotypes to gene IDs. The database has been populated with phenotypic data on 367 P. falciparum genes, curated from 176 individual publications, as well as existing data on rodent Plasmodium species from RMgmDB and PlasmoGEM. This is the first time that all available data on P. falciparum transfection experiments has been brought together in a single place. These data are presented using ortholog mapping to allow a researcher interested in a gene in one species to see results across other Plasmodium species. The collaborative nature of the database enables any researcher to add new phenotypes as they are discovered. As an example of database utility, we use the currently available datasets to identify RAP (RNA-binding domain abundant in Apicomplexa)-domain containing proteins as crucial to parasite survival.
Various Constraints Perceived by Urd Growers in Southern Rajasthan
Authors: Khatik Ramlal , Sharma F.L. , Jain H. K
Published: June 2017

The present study was conducted in Banswara and Udaipur district of Southern Rajasthan. Total 80 urd beneficiary farmers were selected on the basis of random sampling method from the identified districts. The study revealed that timely non-availability of seed minikits of urd at village level, lack of skill about application of chemicals, improper knowledge about application of micro-nutrients, Non–availability of bio-fertilizers at village level, lack of technological guidance at proper time and inadequate knowledge about soil treatments were major constraints perceived by the beneficiary urd growers in the study area.
Impact of Biometric Attendance System on Secondary and Higher Secondary Educational Institutions Across J&K
Authors: Kirmani Mudasir
Published: June 2017

Managing and monitoring attendance of employees is very important aspect for smooth functioning of any public or private organization. To obtain and maintain the attendance of employees in an organization has become a challenging aspect to deal with. In order to avoid human bias and direct human intervention different government institutions have implemented Biometric attendance system in educational institutions to record employee attendance on daily basis. This research work aims to study the impact of Biometric Attendance system(BAS) on educational system vis-a-vis punctuality of employees in an educational institute. The study indicates that biometric modalities are universally secure and accurate, but in practice the scenarios of attendance systems in Jammu & Kashmir has highlighted some loopholes which are existing at present in the Biometric attendance system.
Assessment of Accuracy Enhancement of Back Propagation Algorithm by Training the Model using Deep Learning
Authors: Kahkeshan Baby , Hassan Syed
Published: June 2017

Deep learning is a branch of machine learning which is recently gaining a lot of attention due to its efficiency in solving a number of AI problems. The aim of this research is to assess the accuracy enhancement by using deep learning in back propagation algorithm. For this purpose, two techniques has been used. In the first technique, simple back propagation algorithm is used and the designed model is tested for accuracy. In the second technique, the model is first trained using deep learning via deep belief nets to make it learn and improve its parameters values and then back propagation is used over it. The advantage of softmax function is used in both the methods. Both the methods have been tested over images of handwritten digits and accuracy is then calculated. It has been observed that there is a significant increase in the accuracy of the model if we apply deep learning for training purpose.
Automatic Feedback Generation in Software Performance Engineering: A Review
Authors: Iqbal Javaid , Ul Haq Syed
Published: June 2017

Automation in generation of architectural feedback from performance indexes like probability distributions, mean values and variances has been of interest to the researchers from last decade. It is well established that due to the complexity in interpreting the performance indices obtained from performance analysis of software architecture and short time to the market, an automated approach is vital for acceptance of architecture based software performance engineering approach by software industry. In last decade some work has beendone in this direction. Aim of this paper is to explore the existing research in the field, which will be valuable for researchers looking forward to contributing to this research.
Comparative study on Classification of Digital Images
Authors: Basanth H. B
Published: June 2017

Digital images are widespread today. The use of digital images is classified into natural images and computer graphic images. Discrimination of natural images and computer graphic (CG) images are used in the applications which include flower classification, indexing of images, video classification and many more. With the rapid growth in the image rendering technology, the user can produce very high realistic computer graphic images using sophisticated graphics software packages. Due to high realism in CG images, it is very difficult for the user to distinguish it from natural images by a naked eye. This paper presents comparative study of the existing schemes used to classify digital images.
Hybrid Intrusion Detection System for Private Cloud & Public Cloud
Authors: Gaur Riddhi , Kumari Uma
Published: June 2017

Internet based applications and data storage services can be easily acquired by the end users by the permission of Cloud computing. Providing security to the cloud computing environment has become important issue with the increased demand of cloud computing. Other than the traditional security methods, additional methods like control access, confidentiality, firewalls and user authentication are required in order to provide security to the cloud computing environment. One of the needful components in terms of cloud security is Intrusion Detection System (IDS). To detect various attacks on cloud, Intrusion Detection System (IDS) is the most commonly used mechanism. This paper discusses about the intrusion detection and different intrusion detection techniques namely anomaly based techniques and signature based techniques.
Intrusion Detection System Based on Data Mining Techniques
Authors: Kumra Abhinav , Jeberson W , Jeberson Klinsega
Published: June 2017

Network security is one of the most important non-functional requirements in a system. Over the years, many software solutions have been developed to enhance network security. Intrusion Detection System (IDS) we have provided an overview of different types of intrusion Detection Systems, the advantages and disadvantages of the same. The need for IDS in a system environment and the generic blocks in IDS is also mentioned.The examples are as follows: (1) Misuse intrusion detection system that uses state transition analysis approach, (2) Anomaly based system that uses payload modeling and (3) Hybrid model that combines the best practices of Misuse and Anomaly based intrusion systems.
A Survey on User Authentication Techniques
Authors: Sharmila K , Janaki V. , Nagaraju A
Published: June 2017

Confidentiality and Authentication were once treated different but now-a-days, improvement in technology is demanding both of them to be used together. Though technology is increasing tremendously, smart hackers on the environment always challenges the authentication factors, thereby enforcing more number of factors for authentication to be included. As factors increase, failure rate for authentication may also be more when any one of the factors doesn’t work. A qualitative survey of user authentication systems being used in today’s environment is presented here and a comparative study of various authentication mechanisms used in the world of Information security by various researchers is shown.
High fashion or high fascism? A Kantian analysis of aesthetics, beauty, genius, power and politics
Authors: Grant Brett G.
Published: June 2017

This article explores the response of the fashion world to an incident involving John Galliano. This incident is used as a case study to examine issues about beauty and fashion, the politics of aesthetics, the philosophy of human affairs and the relationships between morality and good citizenship. It seeks to question some conceptions of beauty that circulate within the world of haute couture and also to problematize the use of the term ‘genius’ when this is divorced from any consideration of moral acceptability. Two philosophical works are used to help with this task: Immanuel Kant’s ([1790] 2000) Critique of the Power of Judgment, and Hannah Arendt’s (1992) Lectures on Kant’s Political Philosophy. In exploring whether individuals can be expected to exhibit an acceptable moral condition under a ‘good constitution’, the Galliano incident prompts, in complex ways, consideration of three things: ‘What constitutes a bad man?’, ‘What constitutes a good citizen?’ and ‘What constitutes a good state?’ Corollary questions include, ‘are “the beautiful” and “the good” related?’, and ‘should one who fails to show moral behaviour be considered a genius’?
Nohona i Waena i nā Mo’olelo/living between the stories: Contextualizing drama therapy within an indigenous Hawaiian epistemology
Authors: Lee Soon Rachel K. M.
Published: June 2017

This article explores indigenous Hawaiian epistemology in relation to perspectives in drama therapy in order to discover intersections between these two bodies of knowledge. The author presents a review of literature pertaining to the history and impact of colonialism in Hawaii, and indigenous ways of knowing. Three major themes: place, embodiment and relationship, are discussed in relation to various concepts and approaches in drama therapy. This creates space for this narrative in our body of knowledge and contextualizes drama therapy within an indigenous and postcolonial understanding of well-being.
Os desportos náuticos e o turismo em Portugal. O potencial dos centros de treino de remo.
Authors: Correia André Bettencourt da Câmara , Sebastião Sónia Pedro
Published: June 2017

O turismo desportivo assume-se como uma fonte de receitas a nível mundial obrigando os destinos a conhecer o seu potencial e a desenvolver estratégias de negócio e comunicação para se diferenciarem e tornarem competitivos. Neste artigo, diagnostica-se a oferta e o potencial dos centros de treino de remo para a captação de turistas, evidenciando as oportunidades e ameaças do mercado português, assim como, os pontos fortes e fracos da oferta existente. Recorreu-se a uma abordagem qualitativa, baseada na análise documental e em entrevistas em profundidade a especialistas qualificados. Concluiu-se sobre a existência de um mercado rentável e diferenciado, com condições favoráveis à prática da modalidade. Não obstante, a oferta de infraestruturas é ainda escassa. Os esforços de comunicação, por sua vez, nem sempre são planeados de forma estratégica e assentam em ações de relações públicas (contacto pessoal com prescritores, participação em eventos, assessoria mediática) e comunicação digital.
Wer soll die Zeche zahlen? Diskussion alternativer Organisationsmodelle zur Finanzierung von Rückbau und Endlagerung
Authors: Jänsch Elisabeth , Brunnengräber Achim , von Hirschhausen Christian , Möckel Christian
Published: June 2017

Gemäß dem Verursacherprinzip sollte jedes Individuum für die durch sie oder ihn verursachten Umweltbelastungen und -schäden aufkommen. Demzufolge müssten die Energieversorgungsunternehmen die Kosten des Rückbaus deutscher Atomkraftwerke und der Endlagerung
radioaktiven Abfalls tragen. Die Einrichtung eines öffentlich-rechtlichen Fonds scheint dafür am besten geeignet zu sein. Kritik am Verursacherprinzip selber zeigt aber auch, dass statt der zwanghaften Durchsetzung dieses Prinzips das Suchen einer gesamtgesellschaftlich effizienten
Lösung im Fokus stehen sollte.
Dialogkonferenzen der Allianz Nachhaltige Universitäten: Ein Beitrag zum sektorübergreifenden Nachhaltigkeitsdiskurs
Authors: Aversano-Dearborn Valentina , Lindenthal Thomas , Bohunovsky Lisa
Published: June 2017

Im Herbst 2016 tauschten sich Akteursgruppen aus Universität, Wirtschaft und Zivilgesellschaft auf vier Dialogkonferenzen über Wege der verstärkten Kooperation im Kontext nachhaltiger Entwicklung aus. Besonderheiten des Konzepts, ausgewählte Ergebnisse sowie zentrale
Querschnittsthemen werden in diesem Beitrag vorgestellt.
Macht und Theorie. Wie Macht erforschen?
Authors: Altmann Philipp
Published: June 2017

Reaktion auf zwei Beiträge zum Thema ,,Macht in Umweltpolitik und Umweltforschung” in GAIA: L Partzsch 24/1 (2015), A. Brunnengräber 26/1 (2017)
Razumevanje vloge medicinske sestre pri spremembi življenjskega sloga posameznikov, v preteklosti odvisnih od prepovedanih drog
Authors: Kadenšek Klavdija , Bregar Branko
Published: June 2017

Uvod: Pri obravnavi posameznikov, odvisnih od prepovedanih drog, je pomemben odnos med posameznikom in medicinsko sestro. Namen raziskave je bil raziskati vlogo medicinske sestre pri spremembi življenjskega sloga posameznika, odvisnega od prepovedanih drog.

Metode: Raziskava temelji na kvalitativni raziskovalni metodologiji, uporabljen je bil delno strukturirani intervju. Vzorec je bil namenski (n = 8), vključeni so bili štirje posamezniki, v preteklosti odvisni od prepovedanih drog, in štiri medicinske sestre, zaposlene na področju odvisnosti. Podatki so bil obdelani po metodi analize vsebine. Zanesljivost izvedene raziskave temelji na sledljivosti ugotovitev in doslednosti oziroma transparentnosti analize empiričnega gradiva.

Rezultati: Posamezniki vlogo medicinske sestre prepoznavajo v neobsojajoči podpori, ki jim jo nudijo v pogostih stikih. Medicinske sestre jim zagotavljajo varno okolje, v katerem jim lahko zaupajo svoja intimna doživljanja. Zaupen medosebni odnos nastaja postopoma, osnovan je na nesebičnem sprejemanju posameznika, zaupanju in empatiji. Za učinkovito spodbujanje sprememb posameznikovega življenjskega sloga medicinske sestre potrebujejo nova znanja na področju svetovanja in motiviranja.

Diskusija in zaključek: Sodelujoči v raziskavi rešitev vidijo predvsem v bližini medicinske sestre, saj jim je le-ta v podporo in igra vlogo svetovalke. Po mnenju v raziskavi sodelujočih medicinskih sester, medicinske sestre, zaposlene na področju odvisnosti, pričakujejo več usmerjanega delovanja na področju življenjskega sloga. Zaradi slabše raziskanosti obravnavanega problema v našem prostoru bi bila na tem področju koristna opredelitev koristnih in potrebnih aktivnosti zaposlenih v zdravstveni negi.
The family medicine reference clinic: an example of interprofessional collaboration within a healthcare team
Authors: Poplas Susič Tonka
Published: June 2017

Since being introduced in 2011, family medicine reference clinics (FMRCs) have created several advantages in the treatment of patients, but have also drawn attention to areas where improvements could be made (Poplas Susič, et al., 2013). Consistent with competencies and experts, each chronic patient care protocol as well as the prevention protocol strictly follows guidelines or recommendations that define diagnostic and treatment as well as education pathways for patient care in a family medicine practice. They are harmonised and agreed with experts at different levels of healthcare (primary, secondary and tertiary) (Vodopivec Jamšek, 2013).
Mineral status of Java thin-tailed sheep grazed in Mijen agriculture area, Semarang, Indonesia
Authors: Widiyanto W. , Kusumanti E. , Mulyono M. , Surahmanto S. , Ismadi V. D.Y. B.
Published: June 2017

The objective of this study was to study the mineral status of Java thin-tailed (JTT) sheep grazed in Mijen-Semarang, Central Java. Six month old of male JTT sheep and paddock with field grass vegetation were used in the research. Fifteen male JTT sheeps were divided into three groups consisting of 5 heads per group, and grazing for 2 month (in early rainy season, late rainy season and dry season, respectively). The measured variables were feed consumption, digested organic matter, mineral (calcium, phosphorus, magnesium, copper, zinc) level in forage, feces, blood, and daily body weight gain. The data were analyzed by analysis of variance with one-way classification. Magnesium and zinc status of JTT sheep were adequate, whereas phosphorus status was deficient in all season. Calcium in early and late rainy season were deficient (7.37 and 7.86 mg/100 mL, respectively), whereas in the dry season was adequate (8.70 mg/100 mL). The copper deficiency was found in dry and late rainy season (with the Serum copper level was 0.62 and 0.51 µg/mL, respectively, and borderline in early rainy season (64.7 µg/mL). Serum copper in the late rainy season was lower (P<0.05) than it in early rainy season and dry season. There were seasonal variation of mineral status of Java thin-tailed (JTT) sheep grazed in Mijen agricultural area, Semarang, Central Java.
Mathematical model of growth of two purelines of Padjadjaran female quail aged 0 to 6 weeks
Authors: Anang A. , Indrijani H. , Sujana E.
Published: June 2017

A research was conducted at Quail Breeding Centre of Padjadjaran University.  A hundred quails of female black and brown color of each line was observed from hatch to age of six weeks. Four growth models were compared: Gompertz, Logistic, Richards, and MMF. The best fit was measured with Coefficient of determination (R2) and standard error of prediction (se). The results showed that all observed models have high accuracy with R2 ranging from 0.9950 to 0.9988 for black color, and 0.9984 to 0.9992 for brown color respectively. Standard errors of prediction (SE) ranged from 1.99 g to 4.01 g for black, and from 1.92 g to 2.52 g for brown, respectively. Gompertz model was more favorable with R2 and SE of 0.9988 and 1.99 g for black, and 0.9991 and 1.92 g for brown, respectively. Age at inflection, maximum average daily gains and weights at inflection were 4.18 week, 27.87 g and 100.23 g for black line and 3.38 week, 25.05 g and 75.34 g for brown line, respectively.
Transversalité du sens et relations interartistiques : l’héritage greimassien
Authors: Bertrand Denis , Stange Veronica Estay
Published: June 2017

L’article évalue la contribution de la sémiotique post-greimassienne aux recherches sur les rapports entre les arts. Sa démarche est fondée sur l’hypothèse d’une fécondité conceptuelle de la théorie du langage pour construire un modèle généralisable des relations interartistiques. Ce projet théorique s’appuie sur de nombreux exemples, entre les XVIIIe et XXIe siècles, montrant les liens entre musique, poésie et peinture, entre musique et architecture, et entre peinture, roman et cinéma. Il conduit à dégager d’abord les transpositions qui, limitées au seul plan de l’expression, visent une spécularité sensorielle, formant une « mathesis du sensible ». Approfondissant ensuite les homologies entre les deux plans des langages, on examine la manière dont leurs liens peuvent être remotivés, ouvrant alors sur une conception élargie du semi-symbolisme. Puis, en envisageant la relation interartistique sous la domination du contenu, on s’intéresse aux modalités d’emboîtement et de capture d’une œuvre par une autre, à travers un réexamen d’un motif trans-artistique par excellence : l’ekphrasis. Enfin, eu égard aux spécificités des langages, à leur autonomie et à leur relative étanchéité, on interroge leur résistance au transfert, à partir d’exemples qui, entre tensions et conflictualités, narrativisent les rencontres interartistiques.
The Current State of Black Studies in the United States
Authors: Boyd Melba Joyce
Published: June 2017

“The Current State of Black Studies in the United States” presents the advances and the challenges of the discipline. The perspective of the essay is grounded in the tradition, established in 1915, with the founding of the Association for the Study of Negro Life and History by Dr. Carter G. Woodson, and considers the changes since its entry into mainstream academia in the late 1960s as a result of black student activism. The discussion considers recent research and theoretical paradigms, as well as institutional and societal impediments.
“Mama’s Baby, Papa’s, Too” – Toward Critical Mixed Race Studies
Authors: Essi Cedric
Published: June 2017

This article examines the development of ‘Critical Mixed Race Studies’ (CMRS) as a crucial framework to critically engage with the shift in US racial discourse from long-standing politics of the one-drop rule to a pervasive celebratory multiracialism and its support in the early formation of ‘Mixed Race Studies.’ With a focus on the black-white paradigm, this contribution sketches the preconditions of this academic discourse, discusses a number of its foundational scholarly texts and contrasts them with prominent black critiques. Finally, a call for CMRS as a part of the Black Studies project will be formulated via trend-setting examples.
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Coregulators as mediators of mineralocorticoid receptor signalling diversity
Authors: Fuller Peter J , Yang Jun , Young Morag J
Published: June 2017

The cloning of the mineralocorticoid receptor (MR) 30 years ago was the start of a new era of research into the regulatory processes of MR signalling at target genes in the distal nephron, and subsequently in many other tissues. Nuclear receptor (NR) signalling is modified by interactions with coregulatory proteins that serve to enhance or inhibit the gene transcriptional responses. Over 400 coregulatory proteins have been described for the NR super family, many with functional roles in signalling, cellular function, physiology and pathophysiology. Relatively few coregulators have however been described for the MR although recent studies have demonstrated both ligand and/or tissue selectivity for MR-coregulator interactions. A full understanding of the cell, ligand and promoter-specific requirements for MR-coregulator signalling is an essential first step towards the design of small molecular inhibitors of these protein-protein interactions. Tissue-selective steroidal or non-steroidal modulators of the MR are also a desired therapeutic goal. Selectivity, as for other steroid hormone receptors, will probably depend on differential expression and recruitment of coregulatory proteins.
High-Throughput Characterization of Cascade type I-E CRISPR Guide Efficacy Reveals Unexpected PAM Diversity and Target Sequence Preferences
Authors: Xu Hua Fu Becky , Wainberg Michael , Kundaje Anshul , Fire Andrew Z
Published: June 2017

Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are transcribed and processed to produce small CRISPR RNAs (crRNAs), with degradation of invading genetic material directed by a combination of complementarity between RNA and DNA and in some cases recognition of adjacent motifs called PAMs (Protospacer Adjacent Motifs). Here we describe a general, high-throughput procedure to test the efficacy of thousands of targets, applying this to the Escherichia coli type I-E Cascade (CRISPR-associated complex for antiviral defense) system. These studies were followed with reciprocal experiments in which the consequence of CRISPR activity was survival in the presence of a lytic phage. From the combined analysis of the Cascade system, we found that (i) type I-E Cascade PAM recognition is more expansive than previously reported, with at least 22 distinct PAMs, with many of the noncanonical PAMs having CRISPR-interference abilities similar to the canonical PAMs; (ii) PAM positioning appears precise, with no evidence for tolerance to PAM slippage in interference; and (iii) while increased guanine-cytosine (GC) content in the spacer is associated with higher CRISPR-interference efficiency, high GC content (>62.5%) decreases CRISPR-interference efficiency. Our findings provide a comprehensive functional profile of Cascade type I-E interference requirements and a method to assay spacer efficacy that can be applied to other CRISPR-Cas systems.
A variação estilística em diferentes situações de leitura: variedade capixaba
Authors: Miranda Irma Iunes , Yacovenco Lilian Coutinho , Tesch Leila Maria , Meireles Alexsandro Rodrigues
Published: June 2017

O estilo, juntamente com os recursos linguísticos e sociais, integra os estudos da variação sociolinguística. Com base na proposta de W. Labov, que tem como foco da variação estilística a atenção que o sujeito presta à própria fala, esta pesquisa tem o objetivo de observar se ocorrem diferenças estilísticas entre as leituras de sequência de frases (do tipo “Digo palavra baixinho”) e de um texto (do tipo conto infantil). Os parâmetros observados para tais propósitos são as frequências dos dois primeiros formantes (F1 e F2) de vogais tônicas e pré-tônicas, a duração dessas vogais (Dur) e a ênfase espectral (SE). O resultado confirmou que estilos distintos promovem diferentes reações nos leitores: a leitura de frases descontextualizadas produziu uma fala mais atenta e com traços de formalidade e a leitura do texto, que favoreceu um maior envolvimento do leitor, produziu um estilo mais casual.********************************************************************The style variation in different reading situations: Capixaba varietyAbstract: The style, along with linguistic and social resources, integrates the study of sociolinguistic variation. Based on W. Labov perspective, who mainly focused on the attention that the speaker pays to his/her own speech when he analysed stylistic variation, this research aims to observe possible stylistic differences between sentence reading (type “Digo palavra baixinho”) and text reading (type children’s tale). The parameters analysed for such purposes arethe frequencies of the first an second formants (F1 and F2) of stressed and pre stressed vowels, the duration of those vowels (Dur) and their spectral emphasis (SE). The result confirmed that different styles promote different reactions in readers: the decontextualized sentences reading produced a more monitored speach than the text reading.Keywords: Style; Acoustic analysis; Vowel system; Brazilian Portuguese; Capixaba dialect