bluuebunny/crossref_metadata_2025 huggingface dataset:
Academic advising and ethic of care: Enabling belonging to enhance higher education students’ prospects of success
Authors: de Klerk D.
Published: January 2023

The South African (SA) higher education sector continues to battle high attrition rates. Helping students gain a sense of belonging while at university and creating an environment where students feel cared for can enhance their prospects of success. Academic advising is a high-impact practice with the potential to enhance student belonging and success. This article proposes intentionally linking Tronto’s Ethic of Care (EoC) and academic advising for SA higher education contexts. The author argues that the dimensions of Tronto’s EoC (attentiveness, responsibility, competence, and responsiveness) are relevant to the work of SA advisors. These dimensions are used as a framework for analysing interview data collected from 15 academic advisors from one university. The findings suggest that elements of Tronto’s EoC are present in the advisors’ work, though not explicitly. The author argues that integrating EoC and advising more intentionally in SA higher education contexts, could enable a greater sense of belonging for students. Keywords: academic advising, belonging, care, caring, ethic of care, higher education, South Africa, student advising, student success
Learning to belong: Navigating liminal spaces between disciplinary and teaching identities
Authors: Benvenuti S. , MacGregor A. , de Klerk D. , Padayachee K. , Dison L.
Published: January 2023

The continuous professional learning of academics as university teachers is a national imperative in South Africa. At our university, a Postgraduate Diploma in Education (Higher Education) was introduced in 2015 with the aim to professionalise university teaching through a formal qualification. Students (i.e., candidates) must transition in two ways: firstly, from being disciplinary specialists to being students again; and secondly, into the community of scholarly teaching in higher education. This article examines the liminality experienced by candidates as they navigate the programme and learn to belong to a new scholarly teaching community. Drawing on empirical data collected from graduates and programme coordinators, the authors track candidates’ shifting identities and showcase how, though initially turbulent and unsettling, the process of learning to belong to a new teaching identity can be rewarding and enriching. The authors conclude by discussing the conditions required to enable candidates to acquire a strong university-teacher identity. Keywords: belonging, higher education, identity, liminality, professional learning, threshold concepts
Infective Endocarditis after Transcatheter Aortic Valve Replacement: Challenges in the Diagnosis and Management
Authors: Zakhour Johnny , Allaw Fatima , Kalash Suha , Wehbe Saliba , Kanj Souha S
Published: January 2023

Although initially conceived for high-risk patients who are ineligible for surgical aortic valve replacement (SAVR), transcatheter aortic valve replacement (TAVR) is now recommended in a wider spectrum of indications including young patients. However, as for SAVR, TAVR is also associated with a risk of infectious complications, namely prosthetic valve endocarditis (PVE). As the number of performed TAVR procedure increases, and despite the low incidence of PVE post TAVR, clinicians should be familiar with the associated risk factors and the clinical presentation. Whereas the diagnosis of native valve endocarditis can be straightforward applying the modified Duke criteria, the diagnosis of PVE is more challenging given its atypical symptoms, lower sensitivity of the criteria, and low diagnostic yield of conventional echocardiography. Delay in proper management can be associated with increased morbidity and mortality. Therefore, clinicians should have a high index of suspicion and initiate proper work-up according to the severity of illness, the underlying host, and the local epidemiology of the causative organisms. The most common causative pathogens are Gram-positive bacteria such as S. aureus, coagulase negative staphylococci, Enterococcus spp. and Streptococcus spp. (particularly the viridans group) and, less likely Gram-negative and fungal pathogens. The high prevalence of antimicrobial resistance complicates the choice of therapy. There remain controversies regarding the optimal management strategies including indications for surgical interventions. Surgical assessment is recommended early in the course of illness and surgical intervention should be considered in selected patients. As in other PVE, duration of therapy depends on the isolated pathogen, the host, and the clinical response. Since TAVR is a relatively new procedure, the outcome of TAVR-PVE is yet to be fully understood.
An Unexpected Role for GPR143 in Retinal Homeostasis
Authors: Tung Dorothy , Congrove Nicole R. , Figueroa Anna Gabriela , Bliss Remington M , Zvavamwe Tawanda , McKay Brian S.
Published: January 2023

Age-related macular degeneration is one of the most common causes of blindness, and the incidence exhibits profound racial bias, occurring most frequently in Caucasians. A primary cell type affected in the disease is the retinal pigment epithelium, but the etiology is unclear. The end 10% of the photoreceptor outer segments are shed each day, and the underlying retinal pigment epithelium engulfs, digests, and recycles molecules back to the sensory retina. In previous work, we showed that GPR143 signaling in response to L-DOPA may be effective in the prevention or delay of age-related macular degeneration. In this study, we explore a novel potential effector of GPR143 signaling, that of outer segment uptake and digestion. Using isolated outer segments, labelled with a pH-sensitive marker to fluoresce in lysosomes, we show that GPR143 signaling does not impact outer segment uptake, but does have a significant effect on subsequent degradation. Interestingly, GPR143 signaling did not affect the digestive capacity of the cells, marked by total proteolytic capacity and cathepsin D activity. Rather, our data suggest GPR143 improved endosomal trafficking efficiency of the phagocytosed outer segments to the lysosome. This result is similar to the effect we previously reported for GPR143 on exosome release from the endosomal compartment. Our data illustrate that GPR143 is active in endosomal traffic A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.
Ubiquitin-binding Autophagic Receptors in Yeast: Cue5 and beyond
Authors: Mensah Theresah Nana Ama , Shroff Ankit , Nazarko Taras Y.
Published: January 2023

The selectivity in selective autophagy pathways is achieved via the selective autophagy receptors (SARs) – proteins that bind a ligand on the substrate to be degraded and the Atg8-family protein on the growing autophagic membrane, phagophore, effectively bridging them. In mammals, the most common ligand of SARs is ubiquitin, a small protein modifier that tags substrates for their preferential degradation by autophagy. Consequently, the most common SARs are the ubiquitin-binding SARs, such as SQSTM1/p62 (sequestosome 1). Surprisingly, there is only one SAR of this type in yeast – Cue5, which acts as a receptor for aggrephagy and proteaphagy – pathways that remove the ubiquitinated protein aggregates and proteasomes, respectively. However, recent studies described the ubiquitin-dependent autophagic pathways that do not require Cue5, e.g. stationary phase lipophagy for intracellular lipid droplets and nitrogen starvation-induced mitophagy for mitochondria. What is the role of ubiquitin in these pathways? Here, we propose that the ubiquitinated lipid droplets and mitochondria are recognized by the alternative ubiquitin-binding SARs. Our analysis identifies the proteins that could potentially fulfill this role in yeast. We think that matching of the ubiquitin-dependent (but Cue5-independent) autophagic pathways with the ubiquitin-and-Atg8-binding proteins enlisted here might uncover the novel ubiquitin-binding SARs in yeast.
Are Antarctic Fish Adapted to Face Global Changes? A Study on Antioxidant Enzymes Gene Expression in Trematomus newnesi from Ross Sea, Experimentally Exposed to PFOA
Authors: Pacchini Sara , Piva Elisabetta , Schumann Sophia , Irato Paola , Pellegrino Daniela , Santovito Gianfranco
Published: January 2023

Antarctica is the continent with the lowest local human impact, yet it is still vulnerable to contaminants coming from external sources. Emerging pollutants, like PFAS, pose an increasing threat to this environment and therefore require more in-depth investigations to understand their environmental fate and biological impacts. The present study, part of the AntaGPS project, focuses on expression analysis at the transcriptional level of genes coding for 4 antioxidant enzymes (sod1, sod2, gpx1, gpx4) in different organs of an Antarctic fish species, Trematomus newnesi. The kidney showed a higher level of expression than the liver of wildlife specimens. The mRNA levels were also assessed in fish exposed to 1.5 μg/L of PFOA for 10 days. In the liver, the treatment induced an increase in gene expression for all the considered enzymes, while in the kidney it induced a general decrease. The obtained results constitute a starting point for using the expression of antioxidant enzymes as biomarkers, both of oxidative stress and exposure to PFAS, in future biomonitoring campaigns in the Antarctic marine environment.
PENERAPAN ANTI-SUIT INJUNCTIONS SEBAGAI LANGKAH PENCEGAHAN DIAJUKANNYA SENGKETA KE PENGADILAN ASING DALAM ARBITRASE INTERNASIONAL
Authors: Sant Cynitiya Scandi
Published: January 2023

Penelitian ini menganalisis permasalahan penerapan anti-suit injunctions sebagai langkah pencegahan diajukannya sengketa ke pengadilan asing dalam arbitrase internasional yang berdasarkan dengan prinsip hukum umum, New York Convention, dan UNCITRAL Model Law. Penelitian ini merupakan penelitian hukum normatif yang bersumber pada bahan hukum primer, bahan hukum sekunder, dan bahan hukum tersier, serta menggunakan metode pendekatan konseptual (conceptual approach), pendekatan komparatif (comparative approach), dan pendekatan kasus (case approach). Penelitian ini menggunakan teknik pengumpulan data studi kepustakaan (library research) dengan teknik analisis data logika deduktif. Berdasarkan hasil penelitian, permohonan anti-suit injunctions dipengaruhi oleh seat of arbitration (lex loci arbitri) dan exclusive jurisdiction dari perjanjian arbitrase antar-para pihak, disertai dengan pendapat para ahli hukum dari kasus terdahulu. Penerapan anti-suit injunctions juga dipengaruhi oleh bagaimana hukum suatu negara yang mengatur perjanjian antar-para pihak. Sehingga, setiap yurisdiksi negara memiliki pertimbangan dan putusan yang berbeda dalam memberikan permohonan anti-suit injunctions. Penelitian ini menganalisis permohonan anti-suit injunctions melalui studi kasus yang dibandingkan dari empat yurisdiksi yang berbeda di bawah sistem hukum common law dan civil law yaitu yurisdiksi Inggris berdasarkan kasus UAU v. HVB; yurisdiksi Amerika Serikat berdasarkan kasus CitiBank, N.A. v. Mazza; yurisdiksi Rusia berdasarkan kasus UralTransMash v. Pojazdy Szynowe PESA Bydgoszcz SA; dan yurisdiksi Republik Rakyat Cina berdasarkan kasus Xiaomi v. Inter Digital, Inc.
 
PENGGUNAAN CLUSTER BOMB PADA KONFLIK BERSENJATA DI SURIAH DITINJAU DARI HUKUM HUMANITER INTERNASIONAL
Authors: Janges Zakka Pranggapati
Published: January 2023

This research aims to analyze the use of banned weapon, cluster bomb, in the armed conflict in Syria by studying the reason why the cluster bomb is banned from the historical, philosophical, and sociological point of view. Additionally, writer also analyze the most effective law enforcing mechanism to address the use of said weapon by Syria government. This is normative research utilizing both primary and secondary legal materials. The legal materials collecting technique is library research equipped with deduction technique to analyze the materials. The result show that the use of cluster bomb is prohibited for the said weapon violate the principle of international humanitarian law such as principle of distinction, proportionality, and military necessity. Hence, the use of cluster bomb by Syria government that cause civilian casualties is a war crime. Furthermore, the most effective law enforcing mechanism to address the use of cluster bomb by Syrian government is through United Nation Security Council Resolution whose content refer the issue to be resolved by ICC.
Plan de negocio para la propuesta de una empresa de fabricación y comercialización de bolsas kraft biodegradables - Ate
Authors:   , Ñahuincopa Huacho Diana , Rojas Marcelo Heelen Heeddy , Raucana Chacchi Rosa María
Published: January 2023

El presente plan de negocio de fabricación y comercialización de la empresa “ROTAPAPEL SAC” tiene como objetivo principal reducir la contaminación del medio ambiente, generando un impacto positivo, innovando y diseñando bolsas de papel biodegradable personalizados. La empresa ROTAPAPEL ofrece productos de buena calidad para el cuidado del medio ambiente, que favorecen la conservación. Por otro lado, una de las ventajas competitivas es el diseño personalizado y los distintos tamaños hechos con tinta de agua y gomas ecológicas, de esa forma ayudará a promover la disminución de la contaminación. El proyecto, que lleva como nombre de marca: ROTAPAPEL S.A, pertenece al rubro de bolsas de papel Kraft, que contará con un diseñador gráfico y se utilizará el canal delivery de forma gratuita para llegar a todos nuestros clientes. Es importante mencionar que, en el mercado de las bolsas de papel Kraft no se brindan los servicios que ofrecemos en ROTAPAPEL, ya que la empresa “ROTAPAPEL” optó en crear su propia estrategia para que el cliente pueda sentirse satisfecho con el servicio y la calidad de producto que se va a ofrecer.
Evaluación paisajística de las playas de La Costa Verde (Lima-Perú) mediante parámetros físicos y antropogénicos
Authors:   , Lizarbe Palacios Mary Isabel
Published: January 2023

A lo largo de la costa de Perú, la urbanización intensiva y el desarrollo turístico se han relacionado con el deterioro del paisaje costero. Esta investigación llevó a cabo una evaluación del paisaje de 20 playas urbanas del "Circuito de Playas de la Costa Verde" (CPCV), un corredor de playas clave en Lima (Perú). Para ello, se aplicó el Sistema de Evaluación Escénica Costera (CSES) en tres temporadas diferentes, utilizando lógica difusa para reducir la subjetividad del observador y calcular el índice de evaluación (D). Se evaluaron un total de 26 parámetros para calcular el valor D durante el verano de 2020, invierno de 2020 y verano de 2021 para determinar la variabilidad temporal del paisaje de un sector costero urbano como el CPCV. Los resultados muestran que todas las playas evaluadas se clasifican como sitios muy poco atractivos (Clase V). Además, no se encontraron diferencias significativas entre temporadas sino entre playas. La basura y el factor de perturbación (ruido) fueron los principales parámetros humanos que tuvieron puntuaciones bajas y variables en algunos muestreos e influyeron en el cálculo del valor del índice D. Esta evaluación del paisaje propone nuevas implementaciones de nuevas estrategias y acciones de gestión de playas que se centran en el paisajismo y la conservación de los ecosistemas costeros. Fortalecer el monitoreo para reducir el ruido y la perturbación de la basura y promover un uso costero amigable con el medio ambiente son aspectos vitales que deben implementarse.
Plan de negocio de una nueva agencia digital enfocada en Mypes de Ate
Authors:   , Arroyo Alanya Yenifer Fabiola , Salhua Quispe Paul Emiliano , Santana Sedano Kimberlim , Villarroel Cuzcano Sandra Adriana , Zevallos Ponce Pamela Alexandra
Published: January 2023

MEDIUM es una empresa que ofrece servicios de marketing digital, ubicándose de manera geográfica en el distrito de Ate, como se sabe busca atender los sectores más demandados en el mercado que son el sector textil y gastronómico. El propósito de la empresa es implementar nuevas herramientas tecnológicas, programas que ayuden a las Mypes a lograr sus objetivos de ventas y retener a más clientes por medio de las plataformas digitales, publicidades, contenidos o anuncios. También al contar con una visión, misión y un especialista en la materia hace que nuestra empresa pueda seguir creciendo y no se estanque para llegar a más público.
Plan de marketing digital para el spa de mascotas Puppy Pets
Authors:   , Quispe Palma Karla Nikita Jasidim , Flores Menacho Romina Irina
Published: January 2023

Para posicionar la tienda de animales Puppy Pets, este trabajo de investigación propone utilizar un método de plan de marketing digital. Para una empresa del sector de servicios para mascotas, que ofrece servicios como baño, corte, spa, etc., se analiza la situación existente y se propone una estrategia de marketing digital. El posicionamiento digital y la visibilidad de la empresa en los canales digitales son bajos en comparación con los de sus competidores como consecuencia de la falta de estrategias digitales y de presencia en el sitio web que se descubrió. A través de encuestas y entrevistas en profundidad a los propietarios de macotas, se pudo investigar la viabilidad de la implementación del plan de marketing digital gracias a la metodología cualitativa de la investigación. Este estudio pretende situar la marca dentro de la percepción del público objetivo, produciendo así más fidelización hacia la marca, mayor interacción digital, mejor posicionamiento en el mercado y por lo tanto mayores ventas.
Proyecto de negocio: biomarket de productos naturales
Authors:   , Céspedes Pulido Sandra , Maravi Asipali Sara Luz , Muñoz Berrospi Julia María , Ramírez Cárdenas Jeffry Ralph , Nolasco Contreras Henry Jorge
Published: January 2023

La idea de negocio que proponemos está basada en la implementación del Biomarket SanaVida cuyo objetivo será comercializar productos saludables y orgánicos brindando información clara sobre sus ventajas para fortalecer la salud, para lo cual contaremos con un profesional en nutrición quien dará consultas personalizadas a nuestros clientes. El análisis externo nos da un resultado positivo para nuestro emprendimiento. Asimismo, los resultados del análisis interno, basado en los fundamentos de Michael Porter, nos reafirma lo conveniente y rentable que sería ejecutar esta inversión. La ventaja competitiva que proponemos es sostenible gracias a los productos de calidad con certificación de orgánicos, con asesoría nutricional y con un servicio personalizado que proporcione información clara de las ventajas de preferir productos 100% orgánicos. La estrategia del negocio a largo plazo está enfocada en ganar una porción del público en los mercados de San Borja del 6%, apoyándose con la táctica de penetración de mercado. De las proyecciones efectuadas para implementarlo, hemos concluido en que será necesario un capital de S/173.800; la base de los bienes está estructurada por los aportes de los socios, en un 36,7%, y por una subvención bancaria ascendente al 63,3%.
Evaluación del ciclo de vida del manejo de residuos verdes municipales mediante la gestión de rellenos sanitarios, compost y biocarbón (Kon-Tiki) en Lima
Authors:   , Aquije Ramos Camila Alessandra
Published: January 2023

Objetivo Comparar los beneficios de la mitigación del cambio climático con soluciones basadas en la naturaleza para la gestión de residuos verdes municipales convencionales. Métodos Este estudio analizó la huella de carbono del manejo de una tonelada de residuos verdes municipales (RVM) en Lima Perú bajo 4 escenarios diferentes: 1) Disposición final en relleno sanitario autorizado, 2) Disposición final en un vertedero, 3) compostaje y 4) producción de biocarbón, utilizando un reactor Kon-Tiki de bajo costo y tecnología. Resultados Los resultados demuestran el potencial muy claro para la mitigación del cambio climático a partir de la producción de biocarbón utilizando tecnología de baja tecnología y, por lo tanto, accesible en un contexto típico del mundo en desarrollo. La huella de carbono de la producción de biocarbón fue más baja que la del compostaje y el biocarbón y el compost tuvieron huellas de carbono significativamente más bajas que en los rellenos sanitarios y vertederos. Conclusión Argumentamos que los estándares utilizados por las plataformas nacientes para comercializar los créditos de eliminación de carbono generados por el biocarbón deberían ablandar el requisito de tecnología para favorecer el compromiso y la participación de los participantes del mercado a pequeña escala en los países de bajos ingresos. La gestión de residuos en el mundo en desarrollo presenta desafíos importantes, pero a menudo comienza desde una base muy baja, lo que significa que existe un gran potencial para reducir las emisiones, así como para secuestrar carbono.
Frecuencia y caracterización de la automedicación ante manifestaciones dentales en pacientes que acuden a clínicas privadas en Lima en el año 2021
Authors:   , Arriarán Cisneros Aristides
Published: January 2023

Introducción: La automedicación es la práctica de usar fármacos que no han sido recetados por un profesional de la salud, que muchas veces en vez de ayudar, agravan la salud del paciente. El dolor dental es el principal motivo para la realización de este acto en el área de la odontología. Es importante conocer si los pacientes se automedican para poder desarrollar estrategias para reducir el mal uso de medicamentos y evitar esta práctica. Objetivo: Determinar la frecuencia y caracterización de la automedicación en los pacientes que acudan a las tres clínicas odontológicas privadas entre los meses de marzo a julio del año 2021. Materiales y Métodos: Estudio observacional descriptivo, transversal y prospectivo cuya muestra fue de 450 pacientes de la Clínica Edent’s, Centro Dental San José y Centro Médico de Miraflores. El instrumento de evaluación fue un cuestionario de 13 preguntas sobre las principales características de la automedicación. Resultados: El 85,8% de los pacientes consumen medicamentos sin prescripción médica. El 41,5% de los pacientes se automedicaron por prescripciones antiguas realizadas por el odontólogo. El grupo etario que más se automedicó fue de 26-35 años con 35,5%. El tipo de dolencia más frecuente fue el dolor dental con 45,6%. El grado de instrucción con mayor porcentaje fue Superior Universitario Completo con 32,9%. Conclusiones: La frecuencia de automedicación de los pacientes que acudieron a los tres centros dentales es considerablemente alta.
Tolerancia de juveniles de cabrilla (Paralabrax humeralis Valenciennes, 1828) y chita (Anisotremus scapularis Tschudi, 1846) a condiciones de bajo oxígeno
Authors:   , Montero Taboada Rebeca
Published: January 2023

La hipoxia es actualmente una de las mayores amenazas para los ecosistemas costeros del mundo, generando una mortalidad masiva de organismos marinos, pérdida de ecosistemas bentónicos y una disminución de la producción pesquera. Evaluamos y comparamos la tolerancia a la hipoxia de dos especies de diferentes hábitats de la costa peruana, la cabrilla Paralabrax humeralis y la chita Anisotremus scapularis. El efecto de la hipoxia se midió en función del tiempo de exposición (progresiva y crónica) sobre las respuestas conductuales y fisiológicas de las especies, así como sobre la actividad enzimática asociada a la respuesta al estrés oxidativo (LDH, SOD y AKP). La frecuencia ventilatoria (FV) se midió a dos temperaturas diferentes (16 y 22 ° C) en condiciones de hipoxia progresiva para determinar el punto crítico ventilatorio (Vcp). A. scapularis mostró un Vcp más alto que P. humeralis, el cual fue afectado positivamente por la temperatura. La mediana del tiempo letal (Lt50) de A. scapularis fue de 36 min al 60% de saturación de oxígeno, mientras que P. humeralis no mostró mortalidad después de 31 días de exposición al 5% de saturación de oxígeno. Para ambas especies, bajo hipoxia, se observó un aumento en la actividad de LDH en todas las muestras de tejido (branquias, hígado y músculo), un aumento en la actividad de SOD en hígado y sangre solo para P. humeralis, mientras que se observó una disminución en la actividad de AKP en ambas especies. La respuesta de P. humeralis a la hipoxia pasa por una reducción en la actividad y el metabolismo, por lo que esta especie puede considerarse tolerante a la hipoxia. Por otro lado, la respuesta de A. scapularis a la hipoxia prioriza los mecanismos de evitación y puede considerarse intolerante a la hipoxia...
Relación entre la degradación y la calidad del agua en tres aguajales de la cuenca del río Itaya (Loreto)
Authors:   , Favero Guevara Fiorella Giovanna
Published: January 2023

Los humedales cumplen un importante rol en la mitigación del cambio climático y en la prestación de servicios ecosistémicos. En Perú, la mayor extensión se encuentra en el departamento de Loreto, siendo uno de los más representativos los aguajales. Sin embargo, la alta presión antropogénica enfocada a la extracción del recurso “aguaje” ha promovido su acelerada degradación. Varios estudios han evaluado el impacto de la degradación al ciclo del carbono, pero pocos su relación con otros componentes ecosistémicos tales como la composición florística y la calidad del agua. Esta investigación tiene como objetivo principal determinar la relación entre la calidad del agua y la degradación. Para ello, se seleccionaron tres aguajales, ubicados en la ciudad de Iquitos, con diferentes niveles de degradación (intacto, moderado y degradado) donde se evaluó la composición florística e índices de diversidad y en muestras de agua se analizó la calidad de agua por medio de los parámetros físico-químicos y microbiológicos. Se encontró que existe una relación entre la composición florística y el nivel de degradación, pero no hay una relación entre la calidad del agua y el nivel de degradación. Estos resultados sugieren la importancia de reevaluar los criterios de los niveles de degradación, la evaluación a largo plazo de la calidad del agua en este ecosistema y que futuras investigaciones tengan un enfoque que permita englobar los diferentes componentes de los aguajales.
La gestión del sector restaurantes de comida rápida y su relación con la responsabilidad social empresarial en el distrito de Lince en el año 2020
Authors:   , Aparicio Meiggs Iván Arturo
Published: January 2023

El principal objetivo de esta investigación es determinar la relación existente entre la gestión de los restaurantes de comida rápida del distrito de Lince, ubicado en el centro de la ciudad de Lima y la responsabilidad social empresarial (RSE), en el año 2020, para lo cual realizamos un estudio de tipo correlacional, que tuvo un enfoque cuantitativo y un diseño no experimental, analizándose una muestra conformada por 20 empresas pertenecientes a dicho sector. La información obtenida fue procesada en el sistema estadístico SPSS donde las variables Gestión de Restaurantes de comida rápida y RSE obtuvieron un Alpha de Cronbach de 79.2% y 77.4% respectivamente. Los resultados generales indicaron un grado de correlación positiva con una correlación de Pearson de 72.8% con un p valor = 0.000<0.05. Se concluyó que la variable gestión de restaurantes de comida rápida tiene una correlación directa con la RSE.
Formulación, aceptabilidad y calidad nutricional de fideos fortificados con sangre de pollo en niños de 3 a 5 del distrito de SJM
Authors:   , Trujillo Valverde Percy Antony , Pozo Candia Jassmany
Published: January 2023

Objetivos: Evaluar las características físico-químicas, microbiológicas y aceptabilidad de fideos elaborados a base de sangrecita de pollo en niños que viven en San juan de Miraflores, distrito de Lima. Materiales y métodos: Se llevo a cabo una investigación básica de tipo experimental, tecnológica y descriptiva. La calidad nutricional se determinó mediante los análisis físico-químicos y análisis microbiológicos; y el análisis de aceptabilidad de los fideos se realizó por medio de la escala hedónica facial que consta de cinco puntos, luego de que las madres y/o tutores de los preescolares (menores de 3 a 5 años), recibieran el consentimiento. Resultados: Se elaboraron dos muestras de fideos fortificados, la primera de 16% de sangre de pollo y la segunda de 20%, con cantidades de hierro de 9,1 mg/100 g en la primera formulación y de 11 mg/100 g en la segunda formulación. De acuerdo a los resultados físicos químicos y microbiológicos, los fideos fortificados son aptos para el consumo humano. Conclusión: No se encontró diferencias significativas de aceptabilidad entre ambas formulaciones (16% y 20%).
Sensitised-points acupuncture versus routine integrative acupuncture for chronic low back pain: Protocol for a randomised-controlled feasibility study
Authors: Tan Huijuan , Tumilty Steve , Chapple Cathy , Liu Lizhou , Baxter G David
Published: January 2023

Background
Chronic low back pain (cLBP) is a global health complaint, and a dominant cause of disability. Acupuncture is an effective therapy for cLBP; however evidence for an optimal acupuncture practice scheme is limited. Choosing the most suitable acupoints for stimulation is an essential part of treatment; this not only includes the optimal prescription of points, but also requires accuracy in locating points. The Foundational Chinese medicine classic The Inner Canon of yellow emperor instructs practitioners to palpate the acupoint to find the most sensitive site before inserting needles. Nonetheless, nowadays, palpation is neglected in routine acupuncture practice. The purpose of this study is to determine the feasibility of conducting a randomised controlled trial to assess the potential of sensitised-point acupuncture as non-inferior compared with routine integrative acupuncture for cLBP.
Methods
This will be a two-arm, assessor-blind, non-inferiority feasibility study. Participants will be randomly assigned in a 1:1 ratio into two groups. Each group will receive 8 sessions of sensitised-points acupuncture or routine integrative acupuncture, respectively. Treatments will be conducted twice per week. Primary outcomes will be the feasibility of the study; secondary outcomes will include back pain-related symptoms, expectation and satisfaction towards the treatment. Outcomes will be assessed at baseline (week 0), on a weekly basis during treatment, post-treatment (week 4), and follow-up (week 12).
Discussion
The findings of this study will inform the feasibility and study design of a subsequent fully powered trial.
Trial registration:
Australian New Zealand Clinical Trials Registry (ANZCTR), Ref no.: ACTRN12621001426875. Registered on 21 October 2021,
Q-Learning based Metaheuristic Optimization Algorithms: A short review and perspectives
Authors: Hamad Qusay , Samma Hussein , Suandi Shahrel Azmin
Published: January 2023

In recent years, reinforcement learning (RL) has garnered a great deal of interest from researchers because of its success in handling some complicated issues. Specifically, Q-learning as a model of RL is used a lot in various fields, and it has given an attractive result in games. In recent years, some researchers have tried to exploit the power of Q-learning to improve the results of optimization algorithms by guiding the optimization algorithm search agents based on the data saved in Q-table during the search process. The best search agent is chosen based on its accumulated performance, in other words, how well it has done overall, not how well it has done at each iteration. It is important to note that this review does not focus on reinforcement learning algorithms collaborating with metaheuristic optimization algorithms because there are so many reinforcement learning algorithms and to narrow the scope of the review, this paper will only discuss Q-learning used to enhance metaheuristic optimization algorithms. In this study will look at the huge progress made in the research community by looking at 32 different algorithms proposed on the subject from 2009 to 2022, with a focus on studies published in the last five years. As a result of the surveys conducted in this study, researchers (novices and experts) in the field of metaheuristic optimization algorithms research are expected to gain a better understanding of current research trends involving the use of Q-Learning and new motivations for outlining appropriate strategic plans for future development work as a result of the surveys conducted in this study.
Medication Related Problems and its predictors among heart failure patients at a tertiary care hospital in Ethiopia: A prospective interventional study
Authors: Garedow Aster Wakjira , Tesfaye GorfinehTeshome
Published: January 2023

Background
Medication related problems in cardiovascular disease patients, especially among heart failure patients were found to be high. Medication related problem is a critical problem to provide high quality health care service for the patient which is associated with high mortality, complication, prolonged hospital stay, compromised quality of life and increase health care cost.
Objective
To determine medication related problems and its predictors in hospitalized heart failure patients at Jimma Medical Center, from May 30, 2019 to November 28, 2020
Methods
A prospective interventional study was conducted among heart failure patients from May 30, 2019 to November 28, 2020 at Jimma Medical Center. Medication related problems were sorted based on Pharmaceutical care network Europe drug classification tool version 9.0. Patient’s specific data was collected using questionnaire. The data were coded, cleaned, and entered into Epidata version 4.6 and exported to SPSS version 25.0 for analysis .Binary Logistic regression was used to identify independent predictors of medication related problems occurrence. Variables having P-values < 0.05 were considered statistically significant
Results
A total of 384 heart failure patients were included in the study. The mean (SD) age was 49.06 ± 17.79. Two third of study participants had at least one medication related problem. A total of 483 MRPs were identified among 231(60.15%) patients. Treatment effectiveness related problem (55.48%) was the most common observed medication related problems. Alcoholism (AOR; 3.25, 95% CI (1.46–7.23), prolonged hospital stay [AOR = 3.67, 95%CI= (1.85–7.27)]; comorbidity [AOR = 2.88, 95%CI= (1.47–5.66)] and polypharmacy [AOR = 3.07, 95%CI= (1.57–5.99) were the independent predictors of medication related problems.
Conclusion
The prevalence of medication related problem was high among heart failure patients. Alcoholism, prolonged hospital stay, comorbidity and polypharmacy were the predictors of medication related problems. Hence, to overcome these problems, clinical pharmacists, physicians and other health care professionals have to work in collaboration.
Evolving Ostrom’s first principle: The dynamic evolution of common property rights and their role in resource management
Authors: Andrews Jeffrey , Clark Matthew , Hillis Vicken , Mulder Monique Borgerhoff
Published: January 2023

When and how can collective property rights evolve to effectively manage otherwise open access resources? We introduce a generic but formal modelling framework that explores under what conditions collective property rights over natural resources emerge, the causal mechanisms through which such rights aid in sustainability and the challenges that groups face in maintaining them. Our focus is on both the origins of collective property rights, and the co-evolutionary interactions driving their emergence and stabilization. Results suggest that, in the presence of inter-group conflict over resources, groups must establish and enforce rules regarding access and exclusion before implementing effective internal management. This is because when groups lack boundaries, inter-group conflict erodes surplus gains and impairs groups' ability to identify sustainable management targets. We compare these theoretical insights with empirical data from Pemba, Tanzania on the relationship between inter-group conflicts, and investments in boundaries and internal management. We find that inter-group conflict is positively correlated with support for boundaries but negatively correlated with investment in tree planting activities, supporting our theoretical insights on the evolutionary drivers of collective property rights when borders are porous. We discuss these results in the context of strategies to overcome collective action dilemmas and connections to cultural multi-level selection.
Exploring the bi-directional relationship between periodontitis and dyslipidemia A comprehensive systematic review and meta-analysis
Authors: Ma Wanting , Zou Zhaolei , Yang Lisa , Lin Dongjia , Guo Junyi , Shan Zhongyan , Hu Qiannan , Wang Zhi , Li Bin , Fang Juan
Published: January 2023

Aim
As periodontitis and dyslipidemia are diseases that occur with high incidence, the relationship between them has attracted much attention. Previous studies on these diseases have tended to focus on lipid parameters and periodontitis, we aimed to investigate the relationship between dyslipidemia and periodontitis.
Materials and Methods
Studies were considered eligible if they contained data on abnormal blood lipid parameters and periodontitis. Studies that reported mean differences and 95% confidence intervals or odds ratios were used.
Results
67 publications were included in the meta-analysis. Hyper total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels are risk factors for periodontitis. Periodontal disease is a risk factor for high TG and low HDL levels. Three months after periodontal treatment, the levels of TC, TG and HDL were significantly improved, and statin treatment only improved gingival index (GI) levels compared to that of the dietary control.
Conclusions
The findings reported here suggest that the mutual promotion of periodontitis and dyslipidemia can be confirmed. Non-surgical periodontal therapy may improve lipid abnormalities. It can’t be demonstrated whether systematic application of statins have a better effect on the improvement in periodontal status in patients with dyslipidemia compared to that of the control.
The burden of acute hepatitis C from 1990 to 2019 at the global, regional, and national level
Authors: Ouyang Guoqing , Wang Kunpeng , Liu Zhipeng , Yuan Guandou , Wang Weixing , Mo Jinggang , Jin Chong , Yang Xin , he songqing
Published: January 2023

Aims
Global healthcare costs are significantly increased by acute hepatitis C. In this study, our goal was to assess the prevalence, incidence, and years lived with disability (YLDs) of acute hepatitis C globally in terms of numbers, age-standardized rates (ASRs), and percent changes.
Methods
Data on acute hepatitis C were acquired from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Numbers, ASRs, and percent changes of prevalence, incidence, and YLDs’ rates per 100,000 population were systematically analysed using the GBD 2019 modelled data.
Results
In 2019, acute hepatitis C numbers were 636,315.62 (95% uncertainty interval (UI): 560,704.41–736,991.98), 5,514,735.38 (95% UI: 4,859,438.18–6,387,263.87) and 8914.5 (95% UI: 4256.87–17539.11) for the point prevalence, incidence, and YLDs, respectively. The ASRs were 8.53 (95% UI: 7.54–9.88), 73.93 (95% UI: 65.33–85.60), and 0.12 (95% UI: 0.06–0.24) per 100,000 population for the point prevalence, incidence, and YLDs, respectively. From 1990 to 2019, the percent changes in the age-standardized prevalence, incidence, and YLDs rates decreased. Moreover, Central Sub-Saharan Africa, Central Asia, and Western Sub-Saharan Africa had the highest age-standardized prevalence, incidence, and YLDs rates in 2019. Notably, China exhibited the largest decrease in percentage change in the ASR prevalence, incidence, and YLDs from 1990 to 2019. Additionally, Egypt, Mongolia, and Angola had the highest burden of acute hepatitis C from 1990 to 2019.
Conclusions
Globally, the burden of acute hepatitis C has decreased significantly in many countries over the last 30 years. However, it continues to increase in low-income countries. Therefore, more international cooperation and multifaceted and multisectoral actions are required for the better monitoring of acute hepatitis C.
A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter release
Authors: Cornelisse Lennart , Boven Maaike van , Mestroni Marta , Zwijnenburg Petra , Verhage Matthijs
Published: January 2023

Synaptotagmin-1 (Syt1) is a presynaptic calcium sensor with two calcium binding domains, C2A and C2B, that triggers action potential-induced synchronous neurotransmitter release, while suppressing asynchronous and spontaneous release. We identified a de novo missense mutation (P401L) in the C2B domain in a patient with developmental delay and autistic symptoms. Expressing the orthologous mouse mutant (P400L) in cultured Syt1 null mutant neurons revealed a reduction in dendrite outgrowth with a proportional reduction in synapses. This was not observed in single Syt1PL-expressing neurons that received normal synaptic input when cultured in a control network. Patch-clamp recordings showed that spontaneous neurotransmitter release per synapse was increased more than 500% in Syt1PL-expressing neurons, even beyond the increased rates in Syt1 KO neurons. Furthermore, action potential induced asynchronous release was increased more than 100%, while synchronous release was not changed. A similar shift to more asynchronous release was observed during train stimulations. These cellular phenotypes were also observed when Syt1PL was expressed in wild type neurons. Our findings show that Syt1PL desynchronizes neurotransmission by reducing the suppression spontaneous and asynchronous release. Neurons respond to this by shortening their dendrites, possibly to counteract the increase in release. Syt1PL acts in a dominant-negative manner supporting a causative role for the mutation in the heterozygous patient. We propose that the substitution of a rigid proline to a more flexible leucine at the bottom of the C2B domain impairs clamping of release by interfering with Syt1’s primary interface with the SNARE complex. This is a novel cellular phenotype, distinct from what was previously found for other Syt1 disease variants, and points to a role for spontaneous and asynchronous release in SYT1-associated neurodevelopmental disorder.
Height-dependent differential rotation of the solar atmosphere determined by the CHASE spectroscopic observation
Authors: Rao Shihao , Li Chuan , Fang Cheng , Ding Mingde , Chen Peng-Fei , Li Zhen , Qiu Ye , Hong Jie , Li Kejun , Hao Qi , Guo Yang , Cheng Xin , Dai Yu , Peng Zhixin , You Wei , An Minjie , Yuan Yuan
Published: January 2023

Rotation is an intrinsic property of the stars including the Sun. Studying how stars rotate is essential for modeling their structure, formation and evolution [1, 2], and understanding their interaction with interplanetary environment [3, 4]. The Sun is a unique candidate that we can observe in detail and explore its rotation from the interior to the atmosphere [5, 6]. To date, we still do not know exactly how the Sun rotate depending on the latitude and altitude. The Chinese Hα Solar Explorer (CHASE) [7], the first space-based solar telescope of China, answers the question to a certain extent. The CHASE mission provides seeing-free spectroscopic observations of the whole solar disk at the wavebands of Si I (6560.58 Å), Fe I (6569.21 Å), and Hα (6562.81 Å) with a very high spectral resolution, which facilitates us to derive simultaneously the precise photospheric and chromospheric Dopplergrams [8]. It is found that the Sun rotates faster at higher surface layers from the photosphere to the chromosphere. The equatorial rotation rate is calculated to be 2.79 ± 0.01 μrad s−1 at the bottom of the photosphere, 2.83 ± 0.01 μrad s−1 at the middle photosphere, and 3.07 ± 0.02 μrad s−1 at the upper chromosphere. The ubiquitous frozen-in-plasma magnetic field probably plays the key role in producing the abnormal rotation rates of the solar atmosphere. The results have important implications for the solar dynamo processes and solar atmospheric heating problems.
Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples
Authors: Zheng Haixia , Webster Maree , Weickert Cynthia , Beasley Clare , Paulus Martin , Yolken Robert , Savitz Jonathan
Published: January 2023

Cytomegalovirus (CMV) is a common, neurotrophic herpesvirus that can be reactivated by inflammation and cause neurological disease. CMV replication can in turn worsen inflammation, raising the possibility that poorly controlled CMV infections may contribute to the neuroinflammation underlying some psychiatric disorders. We investigated whether the presence of anti-CMV antibodies in blood were associated with mental illness, suicide, neuroinflammation, and microglial density in the dorsolateral prefrontal cortex in postmortem samples. Data (n = 114 with schizophrenia; n = 78 with bipolar disorder; n = 87 with depression; n = 85 controls) were obtained from the Stanley Medical Research Institute. Gene expression data from a subset of 82 cases were categorized into “high” (n = 30), and “low” (n = 52) inflammation groups based on a recursive two-step cluster analysis using expression data for four inflammation-related genes. Measurements of the density of non-ramified and ramified microglia were available for an independent subset of 51 samples. All analyses controlled for age, sex, ethnicity, postmortem interval, and pH. CMV seropositivity significantly increased the odds of a mood disorder diagnosis (bipolar disorder: OR = 2.49; major depression: OR = 2.62) and among the psychiatric cases, of suicide (OR = 2.21). Samples in the upper tercile of anti-CMV antibody titers were more likely to be members of the “high” inflammation group (OR = 4.41). CMV positive cases also showed an increased ratio of non-ramified to ramified microglia in layer I of the dorsolateral prefrontal cortex (Cohen’s d = 0.81). The results raise the possibility that the reactivation of CMV contributes to the neuroinflammation that underlies some cases of psychiatric disorders.
Planar photonic chips with tailored dispersion relations for high-efficient spectrographic devices
Authors: chen yikai , Fan Zetao , Sun Wenjie , Wang Zekai , Wu Xueqin , Zheng Jiale , Li Junfeng , Zhu Shijun , Zhang Douguo
Published: January 2023

Spectral characterizations play the important roles in both scientific research and industry. Now, there is a growing demand for spectrometers that have the merits of miniaturized size, high-efficiency, and high spectral resolution. Here, a planar photonic chip containing a photonic band gap (PBG) with tailored dispersion relations is proposed to work as a high-efficient compact spectrographic device, taking advantages of its loading Bloch surface waves (BSWs). When this chip was attached to a prism, the angular dispersion power of the low-loss BSWs enhances the spectra resolving ability of this prism without any need for inversion algorithms or physical slits, thus resulting in high efficiency in utilizing the optical signals and retrieving the spectra. The spectra of various source, such as laser, white light, fluorescence emission, and even the Raman scattering light are characterized with the compact high-efficient spectrographic devices. The achieved spectral resolution can be as high as 0.6 nm.