bluuebunny/crossref_metadata_2025 huggingface dataset:
KARDINAL MAZARIN OG FREDERIK IIIs BIBLIOTEKSSAL
Authors: Bøgh Knud
Published: March 2020

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STREJFTOG I DEN JUDAISTISKE AFDELING. I
Authors: Edelmann R.
Published: March 2020

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HOLGER DRACHMANN OG HANS FADER
Authors: Borup Morten
Published: March 2020

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GOTFRED AF GHEMENS FÆRDEN ca. 1486-1510
Authors: Hellinga Lotte , Hellinga Wytze
Published: March 2020

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NYFUNDNE STUCKENBERG-BREVE
Authors: Brøndum-Nielsen Johs.
Published: March 2020

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H. C. ANDERSENS BREVE TIL ROBERT WATT
Authors: Topsøe-Jensen H.
Published: March 2020

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THOMAS BROWNE OG GABRIEL AGKELEYE
Authors: Bøgh Knud
Published: March 2020

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OMKRING FREDERIK III's BIBLIOTEKSSAL OG DENS ARKITEKT
Authors: Bøgh Knud
Published: March 2020

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KONGELIGE PUBLIKATIONER 1655-1674 OG BRØDRENE GØDES BOGTRYKKERI
Authors: Bentzen Ingrid
Published: March 2020

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FRANSKE OPERETTER OG "SPEKTAKELSTYKKER" I KØBENHAVN 1865
Authors: Garde Georg
Published: March 2020

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STAMBØGER FRA TIDEN 1650-1750 I DET KONGELIGE BIBLIOTEK
Authors: Helk Vello
Published: March 2020

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F. A. MÜLLER OG HANS PINAKOTEK
Authors: L. Faaborg N.
Published: March 2020

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DET GRUNDTVIG-BOISENSKE FAMILIEARKIV
Authors: Johansen Steen
Published: March 2020

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TOLSTOJ, BJØRNSON, HANSEN
Authors: Strand Johansen Dot , Ulf Møller Peter
Published: March 2020

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ET KRIGSBYTTE FRA 30-ÅRSKRIGEN
Authors: Ilsøe Harald
Published: March 2020

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CHRISTOFFER SCHRODT - EN DANSK BOGBINDER FRA FREDERIK IIs TID
Authors: Christensen Karsten
Published: March 2020

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THE NUEVA CORONICA Y BUEN GOBIERNO
Authors: Adorno Rolena
Published: March 2020

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DOMPROVSTEN, DER LOVPRISTE SELVMORD
Authors: Bøgh Knud
Published: March 2020

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ANNO DOMINICAE NATIVITATIS
Authors: Petersen Erik
Published: March 2020

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NOTER
Authors: Redaktionen -
Published: March 2020

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Bjørn Ochsner og Det kongelige Biblioteks Kort- og Billedafdeling
Authors: Berggreen Hans
Published: March 2020

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Henry B. Goodwin en skandinavismens företrädare
Authors: Wigh Leif
Published: March 2020

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Bjørn Ochsners forfatterskab
Authors: Lollesgaard Anja , Kæstel Trine
Published: March 2020

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Resumés
Authors: Redaktionen -
Published: March 2020

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Fascinatografi. Den store verden i en lille tavs firkant af papir
Authors: Fausing Bent
Published: March 2020

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Rollespil og jegforståelse - Cindy Shermans (selv)portrætter
Authors: Hjort Øystein
Published: March 2020

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AF MADS LANGES BALINESISKE BREVARKIV
Authors: Buschardt Leo
Published: March 2020

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J. E. G. WALTERS PRAGTVÆRK OM DE NORDISKE FUGLE
Authors: Anker Jean
Published: March 2020

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TRE UDKAST AF H.C.ANDERSEN TIL EN NY BALLONVISE I
Authors: Barfoed Møller Tove
Published: March 2020

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EN KØBENHAVNSK BOGTRYKKERSVEND OG HANS ARBEJDE I SLUTNINGEN AF DET 18. ÅRHUNDREDE
Authors: Ilsøe Ingrid
Published: March 2020

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ABBED VILHELM SØGER RÅD HOS PAVE CØLESTIN
Authors: Boserup Ivan
Published: March 2020

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ET GEMME FOR GEMMER
Authors: Jørkov Birgitte , Tortzen Chr.Gorm
Published: March 2020

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„EN NEDGRAVEN SKAT" DET KGL. BIBLIOTEKS UDLÅN 1778-1820
Authors: Kaatmann Christian
Published: March 2020

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KONG FREDERIK OG MURERMESTER SØRENSEN
Authors: Lind Gunner
Published: March 2020

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ET STYKKE VRAGGODS FRA KONSTANTINOPELS FALD
Authors: Langwitz Smith Ole
Published: March 2020

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BØGER DER GIK DEN ANDEN VEJ HISTORIEN OM HVAD DER BLEV AF DET KONGELIGE BIBLIOTEKS DUBLETTER
Authors: Ilsøe Harald
Published: March 2020

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CARL NIELSEN OG DEN GRÆSKE MUSIK
Authors: Michelsen Thomas
Published: March 2020

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EFTERSKRIFT: „NAZISAMLINGEN" PÅ DET KONGELIGE BIBLIOTEK
Authors: Lauridsen John T.
Published: March 2020

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GAMLE BREVE FORTÆLLER OM FREDERIK PLUM OG JENS IMMANUEL BAGGESEN
Authors: Munk Plum Claus
Published: March 2020

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DA DANSKE MUSIKERE VAR BLEVNE TIL BØRN IGEN
Authors: Fellow John
Published: March 2020

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ALTONAS HEBRAISKE BOGTRYKKERIER
Authors: Arnheim Arthur
Published: March 2020

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STRUENSEES MEDICINSK-LITTERÆRE VIRKSOMHED
Authors: Snorrason E.
Published: March 2020

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HELIOS OG TYPHONEN OM CARL NIELSENS OG ANNE MARIE CARL-NIELSENS OPHOLD I ATHEN 1903
Authors: Ketting Knud
Published: March 2020

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Alfred Messerli, Roger Chartier (red.): Lesen und Schreiben in Europa 1500-1900. Vergleichende Perspektiven - Perspectives comparées - Perspettive comparate. Schwabe & Co. AG - Verlag, Basel, 2000. 652 s.
Authors: Horstbøll Henrik
Published: March 2020

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ET HÅNDSKRIFTFUND I LÜBECK CA. 1620 OM DEN SPINKLE OVERLEVERING AF TO NORSKE NATIONALKLENODIER
Authors: Skovgaard-Petersen Karen
Published: March 2020

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Læsning og bogmarked i 1600-tallets i Danmark
Authors: Appel Charlotte
Published: March 2020

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PROLEGOMENON TO THE BHUTANESE
Authors: Kragh Kate
Published: March 2020

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AT UDGIVE H.C. ANDERSEN-BREVE HISTORISKE OG METODISKE BETRAGTNINGER
Authors: Dreyer Kirsten
Published: March 2020

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Nic. Knudtzon (udg.): Professor, Dr. Ludvig Daaes erindringer og opptegnelser om sin samtid, Det norske språk- og litteraturselskap, Oslo 2003, 467 s
Authors: A.P. Gissel Jon
Published: March 2020

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CARL NIELSEN, SØVNEN, OPUS 18 EN MUSIKTEKST BLIVER TIL
Authors: Bruunshuus Petersen Elly
Published: March 2020

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H. S. PAULLI OG DANSK MUSIKLIV I DET 19. ÅRHUNDREDE
Authors: Schiørring Nils
Published: March 2020

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ET SJÆLDENT SOMMERFUGLEVÆRK
Authors: W. Langer Torben
Published: March 2020

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BOG OG SKRIFT I CEYLON
Authors: K. Nordstrand Ove
Published: March 2020

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DANSKE BELLMANUDGAVER
Authors: Brøndsted Mogens
Published: March 2020

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P. A. HEIBERG OG NIC. ABILDGAARD
Authors: ROHDE H. P.
Published: March 2020

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VORE ÆLDSTE KOMPONEREDE BIND
Authors: Paulli R.
Published: March 2020

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ET MANUSKRIPT TIL ERASMUS BARTHOLINS AFHANDLING OM LYSETS DOBBELTBRYDNING 1669
Authors: Garboe Axel
Published: March 2020

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ET UKENDT DIGT AF TYCHO BRAHE
Authors: Brøndsted Mogens
Published: March 2020

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JOHANNES AABENBARING SOM BLOKBOG
Authors: Fischer Erik
Published: March 2020

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Reconstruction of the morphology and hydrography of the centre of Kraków before the mid-13th century
Authors: Łajczak Adam , Zarychta Roksana
Published: March 2020

The paper concerns investigations on urban geomorphology. The subject of the paper is the historic centre of Kraków (or Cracow) where the pre-human relief became masked due to the rapid increase in cultural deposits from the mid-13th century onwards. The aim of the investigation is the reconstruction of the original topography, relief and hydrography of this area based on rich sources of materials in papers and non-published data on geology, geoengineering, archaeology, history, and also on maps and panoramic drawings of the town. A digital elevation model has been generated, which showed the topography of the study area in the period before the mid-13th century. Structural analysis, cross validation test and estimation by ordinary kriging method were carried out. The final cartographic work was prepared with the use of QGIS and Surfer software. The distribution of landforms in the study area in the mid-13th century is presented as a proposed variant of the geomorphological map prepared by the authors. The former relief was evaluated in terms of its potential for encouraging settlement.
Perspectiva de la publicidad en HbbTV
Authors: Bayo Caballero Eduardo
Published: March 2020

Aún pendientes de que Infoadex (fuente de referencia en el control cuantitativo y cualitativo de la actividad publicitaria en España) publique las cifras de inversión en publicidad del pasado mes de diciembre, todo apunta a que, si no ha sido 2019, será 2020 el primer año en que la inversión registrada en medios digitales en nuestro país supere la del medio televisión.
Introducción: 11 años de Flash
Authors: Casado Carlos
Published: March 2020

Carlos Casado resalta en esta pequeña introducción a los artículos de César Tardáguila y Jaume Gil, la creciente importancia que está experimentando Flash a la hora de crear aplicaciones para la Web. La reciente adquisición de este software por parte de Adobe Systems en 2006 abre nuevas posibilidades a Flash, un producto que en sus once años de existencia no ha encontrado un competidor que se le acerque.
Educlip 2007
Authors: Rodríguez René
Published: March 2020

Educlip es una propuesta que tiene como objetivo fomentar un nuevo estilo en la comunicación educativa y cultural. Para ello parte de dos iniciativas. La primera es la convocatoria de un concurso de clips educativos, en la que los estudiantes muestran las posibilidades de las nuevas tecnologías de la información y la comunicación. La segunda iniciativa consiste en la celebración de las Jornadas Educlip, que este año se llevó a cabo en el edificio del INEF en Barcelona. Los talleres de esta Jornadas fueron impartidos por profesores de varias universidades catalanas y algunos de sus títulos fueron: Guión y creación, Podcast, Publicación y edición de vídeos en Internet, Televisión IP, entre otros.
Probes and Their Horizons
Authors: Keine Stefan
Published: March 2020

A comprehensive theory of selective opacity effects—configurations in which syntactic domains are opaque to some processes but transparent to others—within a Minimalist framework.

In this book, Stefan Keine investigates in detail “selective opacity”— configurations in which syntactic domains are opaque to some processes but transparent to others—and develops a comprehensive theory of these syntactic configurations within a contemporary Minimalist framework. Although such configurations have traditionally been analyzed in terms of restrictions on possible sequences of movement steps, Keine finds that analogous restrictions govern long-distance dependencies that do not involve movement. He argues that the phenomenon is more widespread and abstract than previously assumed. He proposes a new approach to such effects, according to which probes that initiate the operation Agree are subject to “horizons,” which terminate their searches.

Selective opacity effects raise important questions about the nature of locality in natural language, the representation of movement-type asymmetries, correlations between clause structure and locality, and possible interactions between syntactic dependencies. With a focus on in-depth case studies of Hindi-Urdu and German, Keine offers detailed investigations of movement dependencies, long-distance agreement, wh-dependencies, the A/A' distinction, restructuring, freezing effects, successive cyclicity, and phase theory. Keine's account offers a thorough understanding of selective opacity and the systematic overarching generalizations to which it is subject.
Art and Tradition in a Time of Uprisings
Authors: Levine Gabriel
Published: March 2020

Examining radical reinventions of traditional practices, ranging from a queer reclamation of the Jewish festival of Purim to an Indigenous remixing of musical traditions.

Supposedly outmoded modes of doing and making—from music and religious rituals to crafting and cooking—are flourishing, both artistically and politically, in the digital age. In this book, Gabriel Levine examines collective projects that reclaim and reinvent tradition in contemporary North America, both within and beyond the frames of art. Levine argues that, in a time of political reaction and mass uprisings, the subversion of the traditional is galvanizing artists, activists, musicians, and people in everyday life. He shows that this takes place in strikingly different ways for Indigenous and non-Indigenous people in settler colonies. Paradoxically, experimenting with practices that have been abandoned or suppressed can offer powerful resources for creation and struggle in the present.

Levine shows that, in projects that span “the discontinuum of tradition,” strange encounters take place across the lines of class, Indigeneity, race, and generations. These encounters spark alliance and appropriation, desire and misunderstanding, creative (mis)translation and radical revisionism. He describes the yearly Purim Extravaganza, which gathers queer, leftist, and Yiddishist New Yorkers in a profane reappropriation of the springtime Jewish festival; the Ottawa-based Indigenous DJ collective A Tribe Called Red, who combine traditional powwow drumming and singing with electronic dance music; and the revival of home fermentation practices—considering it from microbiological, philosophical, aesthetic, and political angles.

Projects that take back the vernacular in this way, Levine argues, not only develop innovative forms of practice for a time of uprisings; they can also work toward collectively reclaiming, remaking, and repairing a damaged world.
Quantum Entanglement
Authors: Brody Jed
Published: March 2020

An exploration of quantum entanglement and the ways in which it contradicts our everyday assumptions about the ultimate nature of reality.

Quantum physics is notable for its brazen defiance of common sense. (Think of Schrödinger's Cat, famously both dead and alive.) An especially rigorous form of quantum contradiction occurs in experiments with entangled particles. Our common assumption is that objects have properties whether or not anyone is observing them, and the measurement of one can't affect the other. Quantum entanglement—called by Einstein “spooky action at a distance”—rejects this assumption, offering impeccable reasoning and irrefutable evidence of the opposite. Is quantum entanglement mystical, or just mystifying? In this volume in the MIT Press Essential Knowledge series, Jed Brody equips readers to decide for themselves. He explains how our commonsense assumptions impose constraints—from which entangled particles break free.

Brody explores such concepts as local realism, Bell's inequality, polarization, time dilation, and special relativity. He introduces readers to imaginary physicists Alice and Bob and their photon analyses; points out that it's easier to reject falsehood than establish the truth; and reports that some physicists explain entanglement by arguing that we live in a cross-section of a higher-dimensional reality. He examines a variety of viewpoints held by physicists, including quantum decoherence, Niels Bohr's Copenhagen interpretation, genuine fortuitousness, and QBism. This relatively recent interpretation, an abbreviation of “quantum Bayesianism,” holds that there's no such thing as an absolutely accurate, objective probability “out there,” that quantum mechanical probabilities are subjective judgments, and there's no “action at a distance,” spooky or otherwise.
Irony and Sarcasm
Authors: Kreuz Roger
Published: March 2020

A biography of two troublesome words.

Isn't it ironic? Or is it? Never mind, I'm just being sarcastic (or am I?). Irony and sarcasm are two of the most misused, misapplied, and misunderstood words in our conversational lexicon. In this volume in the MIT Press Essential Knowledge series, psycholinguist Roger Kreuz offers an enlightening and concise overview of the life and times of these two terms, mapping their evolution from Greek philosophy and Roman rhetoric to modern literary criticism to emojis.

Kreuz describes eight different ways that irony has been used through the centuries, proceeding from Socratic to dramatic to cosmic irony. He explains that verbal irony—irony as it is traditionally understood—refers to statements that mean something different (frequently the opposite) of what is literally intended, and defines sarcasm as a type of verbal irony. Kreuz outlines the prerequisites for irony and sarcasm (one of which is a shared frame of reference); clarifies what irony is not (coincidence, paradox, satire) and what it can be (among other things, a socially acceptable way to express hostility); recounts ways that people can signal their ironic intentions; and considers the difficulties of online irony. Finally, he wonders if, because irony refers to so many different phenomena, people may gradually stop using the word, with sarcasm taking over its verbal duties.
How AI Is Transforming the Organization
Authors: MIT Sloan Management Review
Published: March 2020

A clear-eyed look at how AI can complement (rather than eliminate) human jobs, with real-world examples from companies that range from Netflix to Walmart.

Descriptions of AI's possible effects on businesses and their employees cycle between utopian hype and alarmist doomsaying. This book from MIT Sloan Management Review avoids both these extremes, providing instead a clear-eyed look at how AI can complement (rather than eliminate) human jobs, with real-world examples from companies that range from Netflix to Walmart. The contributors show that organizations can create business value with AI by cooperating with it rather than relinquishing control to it. The smartest companies know that they don't need AI that mimics humans because they already have access to resources with human capability—actual humans.

The book acknowledges the prominent role of such leading technology companies as Facebook, Apple, Amazon, Netflix, and Google in applying AI to their businesses, but it goes beyond the FAANG cohort to look at AI applications in many nontechnology companies, including DHL and Fidelity. The chapters address such topics as retraining workers (who may be more ready for change than their companies are); the importance of motivated and knowledgeable leaders; the danger that AI will entrench less-than-ideal legacy processes; ways that AI could promote gender equality and diversity; AI and the global loneliness epidemic; and the benefits of robot–human collaboration.

Contributors

Cynthia M. Beath, Megan Beck, Joe Biron, Erik Brynjolfsson, Jacques Bughin, Rumman Chowdhury, Paul R. Daugherty, Thomas H. Davenport, Chris DeBrusk, Berkeley J. Dietvorst, Janet Foutty, James R. Freeland, R. Edward Freeman, Julian Friedland, Lynda Gratton, Francis Hintermann, Vivek Katyal, David Kiron, Frieda Klotz, Jonathan Lang, Barry Libert, Paul Michelman, Daniel Rock, Sam Ransbotham, Jeanne W. Ross, Eva Sage-Gavin, Chad Syverson, Monideepa Tarafdar, Gregory Unruh, Madhu Vazirani, H. James Wilson
absence of clutter
Authors: Stephens Paul
Published: March 2020

An exploration of minimal writing—texts generally shorter than a sentence—as complex, powerful literary and visual works.

In the 1960s and 70s, minimal and conceptual artists stripped language down to its most basic components: the word and the letter. Barbara Kruger, Jenny Holzer, Carl Andre, Lawrence Weiner, and others built lucrative careers from text-based art. Meanwhile, poets and writers created works of minimal writing—visual texts generally shorter than a sentence. (One poem by Aram Saroyan reads in its entirety: eyeye.) In absence of clutter, Paul Stephens offers the first comprehensive account of minimal writing, arguing that it is equal in complexity and power to better-known, more commercial text-based art.

Minimal writing, Stephens writes, can be beguilingly simple on the surface, but can also offer iterative reading experiences on multiple levels, from the fleeting to the ponderous. “absence of clutter,” for example, the entire text of a poem by Robert Grenier, is both expressive and self-descriptive. Stephens first sets out a theoretical framework for reading and viewing minimal writing and then offers close readings of works of minimal writing by Saroyan, Grenier, Norman Pritchard, Natalie Czech, and others. He “reverse engineers” recent works by Jen Bervin, Craig Dworkin, and Christian Bök that draw on molecular biology, and explores print-on-demand books by Holly Melgard, code poetry by Nick Montfort, Twitter-based work by Allison Parrish, and the use of Instagram by Hans-Ulrich Obrist and Saroyan. Text, it seems, is becoming ever more prevalent in visual art; meanwhile, poems are getting shorter. When reading has become scanning a screen and writing tapping out a text, absence of clutter invites us to reflect on how we read, see, and pay attention.
Rhizosphere bacterial and fungal communities during the growth of Angelica sinensis seedlings cultivated in an Alpine uncultivated meadow soil
Authors: An Zhigang , Guo Fengxia , Chen Yuan , Bai Gang , Chen Zhengjun
Published: March 2020

Background

Angelica sinensis seedlings are grown in alpine uncultivated meadow soil with rainfed agroecosystems to ensure the quality of A. sinensis after seedling transplantation. The aim was to investigate the rhizosphere bacterial and fungal communities during the growth stages of A. sinensis seedlings.

Methods

The bacterial and fungal communities were investigated by HiSeq sequencing of 16S and 18S rDNA, respectively.

Results

Proteobacteria and Bacteroidetes were bacterial dominant phyla throughout growth stages. Fungal dominant phyla varied with growth stages, dominant phyla Ascomycota and Chytridiomycota in AM5, dominant phyla Basidiomycota, Ascomycota and Zygomycota in BM5, and dominant phyla Basidiomycota and Ascomycota in CM5. There was no significant variation in the alpha-diversity of the bacterial and fungal communities, but significant variation was in the beta-diversity. We found that the variation of microbial community composition was accompanied by the changes in community function. The relative abundance of fungal pathogens increased with plant growth. We also identified the core microbes, significant-changing microbes, stage-specific microbes, and host-specific microbes. Plant weight, root length, root diameter, soil pH, rainfall, and climate temperature were the key divers to microbial community composition.

Conclusions

Our findings reported the variation and environmental drivers of rhizosphere bacterial and fungal communities during the growth of A. sinensis seedlings, which enhance the understanding of the rhizosphere microbial community in this habitat.
Corroles
Authors: Patra Bratati , Mondal Sruti , Kar Sanjib
Published: March 2020

This article covers the chemistry of corroles, tetrapyrrole macrocycles having relevance with biologically relevant corrin ring of vitamin B12. Corroles are 18π electron aromatic systems like porphyrin. Despite few similarities, corroles have some major differences with porphyrin. Unlike porphyrin, which is dianionic in nature, the inner N4 coordination core of corroles consists of three amino nitrogens and one imino nitrogen, and thus corroles act as trianionic chelating ligands. Corroles are more acidic than porphyrin. As the corrole core is more compressed than porphyrin, the inner π system is more electron rich. Thus, it can stabilize higher oxidation states of metals. Various interesting spectroscopic properties and wide range of applications make corrole one of the most intriguing macrocycles in the porphyrinoid chemistry.
Dosimetric evaluation of synthetic CT generated with GANs for MRI‐only proton therapy treatment planning of brain tumors
Authors: Kazemifar Samaneh , Barragán Montero Ana M. , Souris Kevin , Rivas Sara T. , Timmerman Robert , Park Yang K. , Jiang Steve , Geets Xavier , Sterpin Edmond , Owrangi Amir
Published: March 2020

Purpose

The purpose of this study was to address the dosimetric accuracy of synthetic computed tomography (sCT) images of patients with brain tumor generated using a modified generative adversarial network (GAN) method, for their use in magnetic resonance imaging (MRI)‐only treatment planning for proton therapy.

Methods

Dose volume histogram (DVH) analysis was performed on CT and sCT images of patients with brain tumor for plans generated for intensity‐modulated proton therapy (IMPT). All plans were robustly optimized using a commercially available treatment planning system (RayStation, from RaySearch Laboratories) and standard robust parameters reported in the literature. The IMPT plan was then used to compute the dose on CT and sCT images for dosimetric comparison, using RayStation analytical (pencil beam) dose algorithm. We used a second, independent Monte Carlo dose calculation engine to recompute the dose on both CT and sCT images to ensure a proper analysis of the dosimetric accuracy of the sCT images.

Results

The results extracted from RayStation showed excellent agreement for most DVH metrics computed on the CT and sCT for the nominal case, with a mean absolute difference below 0.5% (0.3 Gy) of the prescription dose for the clinical target volume (CTV) and below 2% (1.2 Gy) for the organs at risk (OARs) considered. This demonstrates a high dosimetric accuracy for the generated sCT images, especially in the target volume. The metrics obtained from the Monte Carlo doses mostly agreed with the values extracted from RayStation for the nominal and worst‐case scenarios (mean difference below 3%).

Conclusions

This work demonstrated the feasibility of using sCT generated with a GAN‐based deep learning method for MRI‐only treatment planning of patients with brain tumor in intensity‐modulated proton therapy.
Reversible obstruction of the olfactory cleft: impact on olfactory perception and nasal patency
Authors: Besser Gerold , Liu David T. , Renner Bertold , Hummel Thomas , Mueller Christian A.
Published: March 2020

Background

Temporary disruption of sensory input can be studied relatively easily for vision or hearing by covering the eyes or ears. In contrast, closing the nostrils affects not only the sense of smell, but also the ability to breathe through the nose and humidify and warm inhaled air. We hypothesized that filling the olfactory cleft (OC) with dissolvable nasal dressing (foam) would temporarily block olfaction while respecting nasal airflow.

Methods

In 30 healthy volunteers, the OC was unilaterally obstructed in a back‐to‐front fashion. Orthonasal and retronasal olfactory function were tested before and after foam application. Ratings of odors and subjective nasal patency (SNP) were collected. Peak nasal inspiratory flow (PNIF) was used to measure nasal patency.

Results

Foam was safely applied in every case using minimal instruments. No complications were reported. Orthonasal and retronasal test results decreased significantly in overall participants (all p < 0.0008). Indicating temporary anosmia, 3 subjects reached the lowest possible score for odor‐threshold testing, with corresponding drops in retronasal test scores. PNIF values before and after foam application were not significantly different (p = 0.11). SNP ratings decreased slightly, but not significantly (p = 0.052). Odor‐intensity ratings dropped significantly (all p < 0.05).

Conclusion

The OC can be safely obstructed with dissolvable nasal dressing, resulting in a decrease in odor‐intensity and orthonasal and retronasal olfactory function test scores. This procedure may serve as a hyposmia model that maintains normal nasal airflow.
Comparison of outcomes between patients with de‐novo sinonasal squamous cell carcinoma vs malignant transformations from inverted papillomas
Authors: Quan Huatao , Zhang Haiyan , Zou Lifen , Yuan Wei , Wang Shengzi
Published: March 2020

Background

The survival difference between de‐novo sinonasal squamous cell carcinoma (DN‐SNSCC) and SCC arising from inverted papillomas (IPs) is unclear. The purpose of this study was to compare the outcomes between DN‐SNSCC and IP‐transformed SNSCC (IP‐SNSCC) patients.

Methods

In this retrospective review, we compared IP‐SNSCC and DN‐SNSCC cases from the Eye and ENT Hospital of Fudan University from 2010 to 2017. A total of 162 patients (39 IP‐SNSCC and 123 DN‐SNSCC) were included in our study. Demographics, tumor characteristics, treatment, and clinical outcomes were analyzed.

Results

The median follow‐up time in all cohorts was 56 (range, 5‐109) months. There was no difference in age, sex, smoking history, alcohol consumption, tumor primary site, or disease stage between the IP‐SNSCC and DN‐SNSCC patients. We also did not find significant differences in overall survival and disease‐free survival between IP‐SNSCC and DN‐SNSCC patients (p = 0.584 and p = 0.238, respectively). The 5‐year local failure rate was 52.8% for IP‐SNSCC patients, which was significantly higher than for those with DN‐SNSCC (31.9%; p = 0.013). The 5‐year nodal failure rate was 19.0% for IP‐SNSCC patients and 8.5% for DN‐SNSCC patients (p = 0.211). The 5‐year distant metastasis rate was 8.0% for IP‐SNSCC patients and 16.1% for DN‐SNSCC patients (p = 0.318).

Conclusion

IP‐SNSCC and DN‐SNSCC patients have similar survival outcomes. IP‐SNSCC seems to have exhibited a higher local failure rate in our study. We believe that IP‐SNSCC is a highly aggressive disease that requires radical treatment. Prophylactic neck treatment should not be omitted in a subset of IP‐SNSCC patients.
Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load
Authors: Perucca Piero , Anderson Alison , Jazayeri Dana , Hitchcock Alison , Graham Janet , Todaro Marian , Tomson Torbjörn , Battino Dina , Perucca Emilio , Ferri Meritxell Martinez , Rochtus Anne , Lagae Lieven , Canevini Maria Paola , Zambrelli Elena , Campbell Ellen , Koeleman Bobby P. C. , Scheffer Ingrid E. , Berkovic Samuel F. , Kwan Patrick , Sisodiya Sanjay M. , Goldstein David B. , Petrovski Slavé , Craig John , Vajda Frank J. E. , O'Brien Terence J. ,   the EpiPGX and EPIGEN Consortia
Published: March 2020

Objective

The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED‐induced BDs may result from a genome‐wide increase of de novo variants in the embryo, a mechanism that we investigated.

Methods

Whole exome sequencing data from child–parent trios were interrogated for de novo single‐nucleotide variants/indels (dnSNVs/indels) and de novo copy number variants (dnCNVs). Generalized linear models were applied to assess de novo variant burdens in children exposed prenatally to AEDs (AED‐exposed children) versus children without BDs not exposed prenatally to AEDs (AED‐unexposed unaffected children), and AED‐exposed children with BDs versus those without BDs, adjusting for confounders. Fisher exact test was used to compare categorical data.

Results

Sixty‐seven child–parent trios were included: 10 with AED‐exposed children with BDs, 46 with AED‐exposed unaffected children, and 11 with AED‐unexposed unaffected children. The dnSNV/indel burden did not differ between AED‐exposed children and AED‐unexposed unaffected children (median dnSNV/indel number/child [range] = 3 [0–7] vs 3 [1–5], p = 0.50). Among AED‐exposed children, there were no significant differences between those with BDs and those unaffected. Likely deleterious dnSNVs/indels were detected in 9 of 67 (13%) children, none of whom had BDs. The proportion of cases harboring likely deleterious dnSNVs/indels did not differ significantly between AED‐unexposed and AED‐exposed children. The dnCNV burden was not associated with AED exposure or birth outcome.

Interpretation

Our study indicates that prenatal AED exposure does not increase the burden of de novo variants, and that this mechanism is not a major contributor to AED‐induced BDs. These results can be incorporated in routine patient counseling. ANN NEUROL 2020;87:897–906
Titanocenes as Photoredox Catalysts Using Green‐Light Irradiation
Authors: Zhang Zhenhua , Hilche Tobias , Slak Daniel , Rietdijk Niels R. , Oloyede Ugochinyere N. , Flowers Robert A. , Gansäuer Andreas
Published: March 2020

Irradiation of Cp2TiCl2with green light leads to electronically excited [Cp2TiCl2]*. This complex constitutes an efficient photoredox catalyst for the reduction of epoxides and for 5‐exocyclizations of suitably unsaturated epoxides. To the best of our knowledge, our system is the first example of a molecular titanium photoredox catalyst.
Preparation and characterization of cellulose‐based nanocomposite hydrogel films containing CuO/Cu2O/Cu with antibacterial activity
Authors: Dharmalingam Koodalingam , Bordoloi Devivasha , Kunnumakkara Ajaikumar B. , Anandalakshmi Ramalingam
Published: March 2020

In the present study, the influence of citric acid (CA) on hydrogel films composed of sodium carboxymethylcellulose (NaCMC), hydroxypropylmethylcellulose (HPMC), and CuO nanoflakes was investigated for their physicochemical, mechanical, thermal, and antibacterial properties. XRD patterns showed that the prepared hydrogel films revealed the crystalline phase for CuO/Cu2O/Cu at 20% CA concentration. Laser micro‐Raman spectroscopy confirmed the presence of CuO and Cu2O in the films. Increase in CA concentration decreased the swelling degree and tensile strength and increased the decomposition temperature of NaCMC, HPMC, and CuO. According to FESEM and FETEM results, shape and size of CuO nanoflakes were completely changed into spherical nanoparticles with increase in CA concentration. HRTEM and inverse Fourier transform images showed that the d‐spacing of CuO, Cu2O, and Cu were correlated with XRD results. The prepared hydrogel films exhibited significant antibacterial activity and biocompatibility against HaCaT cells. All these data recommend that the prepared hydrogel films may be used for potential wound healing applications.
The Utility of Plasma Vascular Biomarkers in Systemic Sclerosis: A Prospective Longitudinal Analysis
Authors: Mecoli Christopher A. , Shah Ami A. , Boin Francesco , Wigley Fredrick M. , Hummers Laura K.
Published: March 2020

Objective

In cross‐sectional studies, pulmonary hypertension (PH) and ischemic digital lesions are 2 scleroderma vascular outcomes associated with abnormalities in biomarkers of angiogenesis. The clinical usefulness of these biomarkers is unknown, in part due to lack of data on longitudinal measurement. This prospective longitudinal study was undertaken to evaluate vascular biomarker measurements in patients with systemic sclerosis (SSc) over time.

Methods

We conducted a prospective cohort study of 300 patients with SSc who were followed up for at least a 5‐year period and lacked evidence of PH and/or active ischemic digital lesions at enrollment. Levels of hepatocyte growth factor (HGF), soluble Flt‐1 (sFlt‐1), soluble endoglin, endostatin, and placental growth factor (PLGF) were obtained at multiple time points and assessed for their ability to predict the development of PH/ischemic digital lesions. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated.

Results

Forty‐six patients (15%) developed PH and 69 patients (23%) developed an ischemic digital lesion. In time‐to‐event analyses, the following 3 biomarkers measured at cohort entry were found to be significantly associated with the development of PH: HGF (HR 1.99 [95% CI 1.24–3.17], P = 0.004), sFlt‐1 (HR 3.04 [95% CI 1.29–7.14], P = 0.011), and PLGF (HR 2.74 [95% CI 1.32–5.69], P = 0.007). As time approaching PH diagnosis decreased, there was no corresponding increase in any biomarker level. Upon converting each continuous vascular biomarker into a binary variable, a dose‐response relationship was observed for the number of elevated biomarkers at cohort entry and the risk of developing PH. With each additional elevated biomarker at cohort entry, there was a 78% increase in the risk of developing PH (HR 1.78 [95% CI 1.2–2.6], P = 0.004).

Conclusion

These data suggest that molecules involved in angiogenesis reflect vascular perturbation, and that elevations in these biomarkers at first encounter can indicate patients who are at risk of PH development.
Planar 2‐Pyridyl‐1,2,3‐triazole Derived Metallo‐ligands: Self‐assembly with PdCl2 and Photocatalysis
Authors: Lagesse Natalie R. , Tan Kelvin Y. L. , Crowley James D. , Findlay James A.
Published: March 2020

Self‐assembled metallosupramolecular architectures (MSAs) with built‐in functionalities such as light‐harvesting metal centers are a promising approach for developing emergent properties within discrete molecular systems. Herein we describe the synthesis of two new but simple “click” ligands featuring a bidentate 2‐pyridyl‐1,2,3‐triazole chelate pocket linked to a monodentate pyridyl (either 3‐ or 4‐substituted, L1 and L2) unit. The ligands and the corresponding four PdIIand PtIImetallo‐ligands (Pd1, Pd2, Pt1 and Pt2) were synthesized and characterized using nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI‐MS), and X‐ray crystallography. Solid‐state characterization of the series of ligands and metallo‐ligands revealed that these compounds display a co‐planar conformation of all the aryl units. The PtIIcontaining metallo‐ligands (Pt1 and Pt2) were found to assemble into square (Sqr) and triangular (Tri) shaped architectures when combined with neutral PdCl2 linker units. Additionally, the ability of the PtIImetallo‐ligands and Tri to photocatalyze the cycloaddition of singlet oxygen to anthracene was investigated.
Adaptive geometric control of quadrotors with dynamic offset between center of gravity and geometric center
Authors: Sharma Manmohan , Kar Indrani
Published: March 2020

A geometric adaptive control of quadrotors has been proposed in this paper when the center of gravity of the quadrotor is different from its geometric center. The unique feature of the controller is the use of left tracking error function to simplify controller design. The inertia matrix, mass as well as the center of gravity are assumed to be unknown and coordinate invariant adaptive laws have been derived for the estimate of these mentioned parameters. The coordinate invariant approach is another unique feature of the proposed method as opposed to the literature. Rigorous mathematical proofs have been prescribed to show the stability of the complete closed loop dynamics under the proposed adaptive laws. The controller has been derived under the assumption that the rotational dynamics is faster than the translational dynamics. Numerical simulations have been shown at the end to show the effectiveness of the proposed method.
Transient performance improvement of Takagi‐Sugeno fuzzy systems by modified non‐parallel distributed compensation controller
Authors: Vafamand Navid
Published: March 2020

This paper addresses the transient performance of nonlinear systems described by Takagi‐Sugeno (TS) fuzzy models. To achieve this goal, a modified fuzzy controller and a non‐quadratic Lyapunov function (NQLF) are utilized. The fuzzy controller comprises an α‐delayed non‐parallel distributed compensation (non‐PDC) and a nonlinear modifying term. The α‐delayed non‐PDC assures the global stabilization of the TS fuzzy systems through the NQLF and linear matrix inequality (LMI) numerical technique. Moreover, the modifying term is used to enhance the transient performance. It is shown that the stability of the closed‐loop system is guaranteed by the α‐delayed non‐PDC and the performance is improved by the modifying term. Two different selections for the modifying term are presented and that they can increase the reaching time of the response and lead to the finite‐time convergence of the state to their equilibrium point is proven. Several numerical and practical systems, that is, a single‐link manipulator and a chaotic permanent magnet synchronous machine, are simulated to illustrate the advantages of the proposed approach. The obtained numerical results are compared with other state‐of‐the‐art methods.
Optimal Control for Discrete‐time Descriptor Noncausal Systems
Authors: Shu Yadong
Published: March 2020

In this paper, optimal control problems governed by linear discrete‐time descriptor noncausal systems (with quadratic input variables) are investigated in order. A descriptor system assumed to be regular alone is called descriptor noncausal system. According to Bellman's principle of optimality in dynamic programming, a recurrence equation for simplifying the optimal control problems is derived. Then, employing the recurrence equation, a bang‐bang optimal control problem subject to a linear descriptor noncausal system and an optimal control problem subject to a descriptor noncausal system with quadratic input variables are both settled, and the optimal solutions are given through exact expressions. A numerical example is presented to illustrate the effectiveness of the results obtained concerning the bang‐bang optimal control problem.
Electrolytes for Lithium (Sodium) Batteries Based on Ionic Liquids: Highlighting the Key Role Played by the Anion
Authors: Rüther Thomas , Bhatt Anand I. , Best Adam S. , Harris Kenneth R. , Hollenkamp Anthony F.
Published: March 2020

Research since 2000 has clearly shown that ionic liquids (ILs) and their metal salt containing mixtures have good potential to be considered as electrolytes (ILELs) in lithium and other electropositive metal (ion) batteries. This outcome is particularly relevant for the operation of such devices in elevated temperature regimes where ILELs would have a significant advantage over the conventional organic carbonate solvent/LiPF6 electrolytes that, due to their limited thermal stability and flammability, cause concerns about the safety of current LIB technology. There is evidence from a number of review articles that physicochemical properties can be tailored such that ILELs could meet requirements for operating in batteries at lower temperature regimes. By drawing on a broad range of cation/anion combinations, there is further evidence from these papers that within a particular family of cations, the physicochemical properties of ILs and ILELs are largely defined by the anion component. Despite the key role of the anion there are few reviews that have sections dedicated to this aspect. This review surveys the physicochemical, transport and structural properties of ILs (mainly pyrrolidinium salts) and ILELs employing prominent and representative anion classes.
Corporate practices and ethical tensions: Researching social justice values and neoliberal paradoxes in a ‘no excuses’ charter school
Authors: Stahl Garth D.
Published: March 2020

In recent years, there has been growing debate over the corporatisation of schooling, specifically the managerial practices of expanding charter school networks in the USA, often referred to as charter management organisations (CMOs). By definition, CMOs are consistently high‐performing, well‐financed networks of small schools operating in urban spaces, which adhere to a very specific ‘no excuses’ (NE) model of education in serving primarily students of colour living in poverty. This article is an autoethnographic account of my work as a leader in a CMO, which I theorise as a neoliberal project. We know very little of how neoliberal policies and ideologies are enacted in daily school life. I consider how the ethical responsibility of an educator is positioned within the daily practices and lived experience of leaders and educators working in a CMO. In focusing on my own ethical tensions, the article captures how this corporatised model of schooling influenced my values as an educator, my conflicted sense of social justice and the emotional labour of enacting a model of schooling founded on surveillance and accountability.
ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia‐related changes and normal karyotype
Authors: Prats‐Martín Concepción , Burillo‐Sanz Sergio , Morales‐Camacho Rosario M. , Pérez‐López Olga , Suito Milagros , Vargas Maria T. , Caballero‐Velázquez Teresa , Carrillo‐Cruz Estrella , González José , Bernal Ricardo , Pérez‐Simón José A.
Published: March 2020

Acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) are poor outcome leukemias. Its diagnosis is based on clinical, cytogenetic, and cytomorphologic criteria, last criterion being sometimes difficult to assess. A high frequency of ASXL1 mutations have been described in this leukemia. We sequenced ASXL1 gene mutations in 61 patients with AML‐MRC and 46 controls with acute myeloid leukemia without other specifications (AML‐NOS) to identify clinical, cytomorphologic, and cytogenetic characteristics associated with ASXL1 mutational status. Mutated ASXL1 (ASXL1+) was observed in 31% of patients with AML‐MRC compared to 4.3% in AML‐NOS. Its presence in AML‐MRC was associated with older age, a previous history of myelodysplastic syndrome (MDS) or myelodysplastic/myeloproliferative neoplasms (MDS/MPN), leukocytosis, presence of micromegakaryocytes in bone marrow, lower number of blasts in bone marrow, myelomonocytic/monocytic morphological features and normal karyotype. ASXL1 mutation was not observed in patients with myelodysplastic syndrome‐related cytogenetic abnormalities or TP53 mutations. Differences in terms of overall survival were found only in AML‐MRC patients without prior MDS or MDS/MPN and with intermediate‐risk karyotype, having ASXL1+ patients a worst outcome than ASXL1−. We conclude that the ASXL1 mutation frequency is high in AML‐MRC patients being its presence associated with specific characteristics including morphological signs of dysplasia. This association raises the possible role of ASXL1 as a surrogate marker in AML‐MRC, which could facilitate the diagnosis of patients within this group when the karyotype is normal, and especially when the assessment of multilineage dysplasia morphologically is difficult. This mutation could be used as a worst outcome marker in de novo AML‐MRC with intermediate‐risk karyotype.
Biosynthetic Plasticity Enables Production of Fluorinated Aurachins
Authors: Sester Angela , Stüer‐Patowsky Katrin , Hiller Wolf , Kloss Florian , Lütz Stephan , Nett Markus
Published: March 2020

Enzyme promiscuity has important implications in the field of biocatalysis. In some cases, structural analogues of simple metabolic building blocks can be processed through entire pathways to give natural product derivatives that are not readily accessible by chemical means. In this study, we explored the plasticity of the aurachin biosynthesis pathway with regard to using fluoro‐ and chloroanthranilic acids, which are not abundant in the bacterial producers of these quinolone antibiotics. The incorporation rates of the tested precursor molecules disclosed a regiopreference for halogen substitution as well as steric limitations of enzymatic substrate tolerance. Three previously undescribed fluorinated aurachin derivatives were produced in preparative amounts by fermentation and structurally characterized. Furthermore, their antibacterial activities were evaluated in comparison to their natural congener aurachin D.
Procedural, pregnancy, and short‐term outcomes after fetal aortic valvuloplasty
Authors: Patel Neil D. , Nageotte Stephen , Ing Frank F. , Armstrong Aimee K. , Chmait Ramen , Detterich Jon A. , Galindo Alberto , Gardiner Helena , Grinenco Sofia , Herberg Ulrike , Jaeggi Edgar , Morris Shaine A. , Oepkes Dick , Simpson John M. , Moon‐Grady Anita , Pruetz Jay D.
Published: March 2020

Objectives

We aimed to evaluate the effect of technical aspects of fetal aortic valvuloplasty (FAV) on procedural risks and pregnancy outcomes.

Background

FAV is performed in cases of severe mid‐gestation aortic stenosis with the goal of preventing hypoplastic left heart syndrome (HLHS).

Methods

The International Fetal Cardiac Intervention Registry was queried for fetuses who underwent FAV from 2002 to 2018, excluding one high‐volume center.

Results

The 108 fetuses had an attempted cardiac puncture (mean gestational age [GA] 26.1 ± 3.3 weeks). 83.3% of attempted interventions were technically successful (increased forward flow/new aortic insufficiency). The interventional cannula was larger than 19 g in 70.4%. More than one cardiac puncture was performed in 25.0%. Intraprocedural complications occurred in 48.1%, including bradycardia (34.1%), pericardial (22.2%) or pleural effusion (2.7%) requiring drainage, and balloon rupture (5.6%). Death within 48 hr occurred in 16.7% of fetuses. Of the 81 patients born alive, 59 were discharged home, 34 of whom had biventricular circulation. More than one cardiac puncture was associated with higher complication rates (p < .001). Larger cannula size was associated with higher pericardial effusion rates (p = .044). On multivariate analysis, technical success (odds ratio [OR] = 10.9, 95% confidence interval [CI] = 2.2–53.5, p = .003) and later GA at intervention (OR = 1.5, 95% CI = 1.2–1.9, p = .002) were associated with increased odds of live birth.

Conclusions

FAV is an often successful but high‐risk procedure. Multiple cardiac punctures are associated with increased complication and fetal mortality rates. Later GA at intervention and technical success were independently associated with increased odds of live birth. However, performing the procedure later in gestation may miss the window to prevent progression to HLHS.