bluuebunny/crossref_metadata_2025 huggingface dataset:
Potentiodynamic Study of The Effects of Nickel on The Electrodeposition of Zinc from Chloride Media
Authors: Zakiyya Hanna , Kékesi Tamás
Published: July 2023

Abstract. The potentiodynamic experiments of the nickel effects on the zinc electrodeposition have been done to understand the impact of Ni impurities on the electrowinning of Zn from spent pickling liquor. The nickel chloride solutions of Ni concentrations 90 and 1 g/dm3 were used as the electrolytes. The latter was also mixed with 90 g/dm3 Zn in the experiments. All the runs were carried out at room temperature with 40 mV/s continuous polarization speed and with 1/s sampling rate. It was observed that nickel electrodeposition from chloride media containing 90 g/dm3 Ni started with the generation of hydrogen bubbles, entirely blocking the cathode surface. Only a slight current development was observed until the polarization potential ~ -0,8 V. The visual observation showed bubbles also formed at the anode, which may represent chlorine and/or oxygen evolution. While, in the electrodeposition of nickel with only 1 g/dm3 Ni concentration in the electrolyte, metal deposition was hardly observed, but visible hydrogen bubbles constantly blocked the cathode surface. A similar tendency was observed in the mixed-solution electrolysis cell; the initial tiny bubbles accumulated at the cathode surface more than in the pure Zn solution. The enhancement of H2 evolution indicates how nickel deposition may contribute to the loss of useful current in the process of Zn electrodeposition. The mass of nickel deposited from the mixed solutions significantly decreases as the Ni concentration decreases in the electrolyte, while the mass of deposited zinc is relatively constant. It means that the purity of the produced Zn is appreciably higher – with respect to Ni – if nickel is efficiently eliminated from the solution before electrowinning.
Surface Quality of Carbide Metal After Electrical Discharge Machining
Authors: Straka Ľuboslav , Kuchta Patrik
Published: July 2023

Recently, the requirements for machining shape-complex products made of hard-to-machine materials, including carbide, have been increasing significantly. However, their machining is rather problematic. Additionally, a high-quality standard of the machined surface is generally required, not only in terms of roughness but also in terms of the geometric accuracy of the machined surface. All this while maintaining a high level of economy in the machining process. However, meeting these demanding requirements in real technical practice is not always an easy task. Moreover, in combination with modern machining processes, only a limited number of production technologies can meet this requirement. Therefore, due to the high demands placed on today's modern production and the required high standard of the machined surface, progressive EDM technology is increasingly finding its application. And it is through this progressive technology that it is possible to achieve relatively good success in carbide machining. The aim of this paper was therefore to describe in detail the results of an experimental investigation aimed at identifying the quality of the machined surface achieved in terms of the roughness parameters of the machined surface in the electrical discharge machining of selected types of carbides using a wire tool electrode.
Teaching the Analysis of Newton’s Cooling Model to Engineering Students
Authors: Kézi Csaba
Published: July 2023

To apply mathematical methods to physical or other real life problem, we have to formulate the problem in mathematical terms. It means that, we have to construct the mathematical model for the problem. Many physical problems shows the relationships between changing quantities. The rates of change are represented mathematically by derivatives. In this case the mathematical models involve equations relating an unknown function and one or more of its derivatives. These equations are the differential equations. In this article, teaching the analysis of Newton's cooling model to engineering students is presented as one of the applications of separable differential equations.
Mixing Power Requirement Determination in Agitated Drum Using Dimensional Analysis
Authors: Horváth Dániel , Poós Tibor
Published: July 2023

The mixing of granular materials in an agitated drum can be characterized by the dimensionless power equation. The equation was created by dimensional analysis, for which the parameters affecting the mixing power requirement were collected based on the literature. The most important of these are the rotational speed, the drum loading factor, the geometric and physical properties of the mixing drum and the granular materials.  The dimensionless power equation is used to estimate with reasonable accuracy the Power number within the given range of applicability , which has been validated by measurements. From the Power number, the mixing power requirement of the mixed granular material can be calculated, which can be used as operational data for selecting the mixing motor.
Editorial
Authors: Pereira Íris Susana Pires , Martinho Maria Helena , Gomes Maria João
Published: July 2023

Este editorial assinala o início de um novo ciclo no trajeto da Revista Portuguesa de Educação (RPE), já que o presente número (n.º 1, Vol. 36) é o primeiro que reúne trabalhos entretanto disponibilizados na modalidade de publicação contínua.
Investigating the effect of destination image on revisit intention through tourist satisfaction in Laguna Redang Island Resort, Terengganu
Authors: Rosli Nur Akmal , Zainuddin Zaliha , Yusliza Mohd Yusoff , Muhammad Zikri , Saputra Jumadil
Published: July 2023

Tourism is a prominent and rapidly expanding sector that plays a pivotal role in driving global economic development. Extensive scholarly literature exists on the influence of destination image on tourists' future behavior, with a particular focus on coastal tourism destinations. However, there remains a scarcity of studies examining this research topic within the context of Malaysia. Consequently, this paper aims to address this gap by investigating the relationship between the destination image of Laguna Redang Island Resort, one of the most renowned resorts situated on Redang Island, Terengganu, and tourist satisfaction and revisitation intentions. To achieve this objective, a cross-sectional quantitative survey was conducted, gathering 361 valid responses from both local and international tourists who were residing at Laguna Redang. The collected data were subsequently analyzed using Smart PLS. The study's findings regarding the impact of the destination image are thoroughly discussed, alongside practical implications that pertain to destination management organizations. Significantly, this study contributes both theoretically and empirically to the body of knowledge surrounding destination image, enhancing our comprehension of its influence on revisitation intentions. Furthermore, it assists in guiding the management activities of Laguna Redang Island Resort, aiding in the reconstruction of the resort's image as a secure and desirable destination for all types of travelers.
Bioinformatics Analysis of Immune Infiltration In Endometrial Carcinoma Tumors and its Relationship With Prognosis
Authors: LIN YAO , LIU SONGYI , BIAN LIHONG , LIN CHUNLIN , LIN PENGHANG , TENG ZUHONG , HOFFMAN ROBERT M. , ZHU GUANGWEI , ZHANG BIN
Published: July 2023

Background/Aim: Endometrial carcinoma (EC) is the most common gynecological cancer, but lacks specific targetable markers. In order to explore the immune-related molecules that affect the progression and prognosis of EC, we analyzed the differential expression of genes in different histological grades of the disease. Materials and Methods: EC-related gene-expression data of different histological grades were downloaded from TCGA and GEO databases. The list of immune-related genes was obtained from the ImmPort database. In order to identity differentially-expressed genes (DEGs), differential-expression analysis was performed. The intersection of DEGs and immune-related genes was termed immune-related differentially-expressed genes (IRDEGs). IRDEGs were enriched in cancer-related functional pathways by gene-correlation analysis and GSEA-enrichment analysis. The association of IRDEGs with immune-cell tumor infiltration and gene polymorphisms was analyzed using IRDEG mRNA and protein-expression data in EC from TCGA and THPA databases. Results: Three IRDEGs, TNFSF15, SEMA3E and TNFSF10, were involved in the analysis of the prognosis of EC patients. IRDEGs were not only related to clinical characteristics but could also affect the prognosis of patients. Gene-correlation and GSEA-enrichment analysis of IRDEGs showed that TNFSF15 and TNFSF10 were co-enriched in the IL2-STAT5 functional pathway. IRDEGs had a significant correlation with a variety of immune-cell types infiltrating EC tumors and were related to EC prognosis. IRDEG mRNA- and protein-expression levels were increased in EC compared to normal tissues. Conclusion: TNFSF15, SEMA3E and TNFSF10 may regulate the progression and prognosis of EC patients by affecting immune-cell infiltration of EC tumors.
A Case of Tracheoesophageal Fistula in a Non-metastatic Site During Lenvatinib Treatment for Hepatocellular Carcinoma
Authors: YOKOTA KEIICHIRO , KITAGAWA HIROYUKI , OKAMOTO KEN , NAMIKAWA TSUTOMU , MAEDA HIROMICHI , KOBAYASHI MICHIYA , SEO SATORU
Published: July 2023

Background/Aim: We report a case of tracheo-esophageal fistula at a non-metastatic site during lenvatinib treatment of hepatocellular carcinoma with multiple bone metastases. Case Report: A 58-year-old male patient was diagnosed with hepatocellular carcinoma with multiple bone metastases and was treated with atezolizumab-bevacizumab. However, as the bone metastasis progressed, palliative radiation therapy was administered to the third thoracic vertebra, and lenvatinib was administered as a second-line treatment. The patient was hospitalized for aspiration pneumonia five months later. Chest computed tomography and bronchoscopy revealed a 5 cm tracheoesophageal fistula located 3 cm cranial to the carina. We diagnosed a benign tracheoesophageal fistula due to lenvatinib because his previous CT scan showed no metastases at the site of the fistula, and we performed esophageal bypass surgery 4 weeks after discontinuation of the lenvatinib. Conclusion: To the best of our knowledge, this is the first case report of tracheoesophageal fistula at a nonmetastatic site during lenvatinib treatment for hepatocellular carcinoma.
Avoiding Dosimetric Risk Factors for Complications in Neoadjuvant Chemoradiotherapy for Lung Cancer: Conventional Radiotherapy Versus Intensity-modulated Radiotherapy
Authors: TAKAHASHI SHIGEO , ANADA MASAHIDE , KINOSHITA TOSHIFUMI , NISHIDE TAKAMASA , SHIBATA TORU
Published: July 2023

Background/Aim: We compared three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for avoiding dosimetric risk factors related to pulmonary complications after neoadjuvant chemoradiotherapy followed by surgery (NACRT-S) for non-small cell lung cancer (NSCLC). Patients and Methods: We performed simulations in 11 patients with dosimetric risk factors during their treatment with NACRT-S for NSCLC. Radiation treatment plans were generated using 3D-CRT and IMRT to avoid dosimetric risk factors. Regarding dose–volume histogram (DVH) parameters, we calculated the percentage of lung volume that received more than x Gy (Vx) using 1) the total lung volume minus gross tumor volume (DVHg), 2) the lung volume remaining after surgery (DVHr), and 3) the contralateral lung volume (DVHc). We analyzed the dosimetric differences between 3D-CRT and IMRT. Results: V35g and V40g were significantly lower with IMRT than with 3D-CRT (p=0.001 each); the median V35g and V40g were 16.1% and 14.9% with 3D-CRT versus 12.0% and 9.2% with IMRT, respectively. Overall, 0% and 55% of the patients were able to avoid all dosimetric risk factors with 3D-CRT and IMRT, respectively (p=0.006). Even with IMRT, tumor location and length of the planning target volume (PTV) significantly affected the avoidance of all dosimetric risk factors (p=0.015 and 0.022, respectively). Conclusion: IMRT is more useful than 3D-CRT for avoiding dosimetric risk factors in NACRT-S for NSCLC. For further improvements in avoiding these factors, respiratory motion managements to reduce the length of the PTV may be required for patients with middle or lower lobe tumors.
Prognosis of Patients Receiving Chemotherapy for Metastatic Upper Tract Urothelial Carcinoma Compared With Metastatic Urinary Bladder Cancer
Authors: ADOMI SHOGO , FUJITA KAZUTOSHI , KITA HIROYUKI , KUWAHARA KEN , AKASHI YASUNORI , NISHIMOTO MITSUHISA , MATSUMURA NAOKI , SUGIMOTO KOICHI , MINAMI TAKAFUMI , NOZAWA MASAHIRO , YOSHIMURA KAZUHIRO , TAHARA HIDEO , HIRAYAMA AKIHIDE , NISHIOKA TSUKASA , ESA ATSUNOBU , UEMURA HIROTSUGU
Published: July 2023

Background/Aim: The treatment strategy for metastatic upper tract urothelial carcinoma (mUTUC) is currently based on the evidence from metastatic urinary bladder cancer (mUBC). However, some reports have shown that the outcomes of UTUC differ from those of UBC. Therefore, we retrospectively analyzed the prognosis of patients with mUBC and mUTUC treated with first-line platinum-based chemotherapy. Patients and Methods: Patients who underwent platinum-based chemotherapy at the Kindai University Hospital and affiliated hospitals between January 2010 and December 2021 were included in the study. There were 56 patients with mUBC and 73 with mUTUC. Kaplan–Meier curves were used to estimate progression-free (PFS) and overall (OS) survival. Multivariate analyses were performed using Cox proportional hazards model to predict prognostic factors. Results: The median PFS was 4.5 and 4.0 months for the mUBC and mUTUC groups, respectively (p=0.094). The median OS was 17.0 months for both groups (p=0.821). The multivariate analysis showed no prognostic factor for PFS. The multivariate analysis for OS showed that younger age at the initiation of chemotherapy and immune checkpoint inhibitor use after first-line therapy were significantly associated with better OS. Conclusion: Platinum-based chemotherapy had a similar effect on patients with mUTUC and mUBC.
Development of a novel microdevice for sorptive extraction under a green analytical chemistry approach: Application for bioanalytical determination of Ibuprofen
Authors: Riera-Williams Jessica P. , Ponce-Rodríguez H.D.
Published: July 2023

This study proposes a novel device called micro polymeric magnetized bar adsorptive extraction (µ-PMBAE), as an extraction and enrichment technique for trace analysis in aqueous samples. These micro-bar absorbent devices were prepared using easily accessible and low-cost materials, incorporating different sorbent materials into a polymer and introducing a small piece of neodymium magnet. Several stability tests were applied to determine their robustness, stability, and weight variation; finally, ibuprofen concentration in urine samples was determined, demonstrating the applicability of extraction devices under a green analytical chemistry approach. The µ-PMBAE showed remarkable advantages since different sorbents can be added to the hot melt glue. This tunes the interaction with the analytes to become more specific in the extraction. Likewise, the magnetic ability makes it possible to carry out extraction without using an extra stir bar, matching its performance with the traditional commercially based on polydimethylsiloxane phase. The proposed analytical method demonstrated excellent performance concerning high recovery percentages, adequate coefficients of variation, and low detection limits.
Investigation of Crohn's Disease by Immunohistochemistry Technique in Iraqi Patients
Authors: Fayadh Sameer Adnan
Published: July 2023

Crohn's disease (CD) is one of the most common IBD types. CD necessitates an erratic immune response. Previous research has shown that inflammation of the intestines is elevated or continues due to inappropriate immune responses that result from the relationships between environmental factors, intestinal microbiota, and genetic factors. Induces intense transmural inflammation. This study aimed to investigate (i) CD detection by Histopathology and Immunohistochemistry (IHC) Markers that are Mycobacterium avium subspecies paratuberculosis MAP antibody and TWEAK/Fn14 antibody and their association with CD. (ii) Prove or disprove the hypothesis of MAP as a potential cause of CD. Tissue biopsies of 30 cases with a recognized diagnosis of CD and 20 cases as control presented without disease symptoms were collected. They are 20 males and 10 females for patients, and 13 males and 7 females for control with ages ranging from 9-55(±34.78) years. From 2019 - 2020, Biopsies were collected from Medical City Hospitals in Baghdad. One tissue section has been stained by the Hematoxylin & Eosin (H&E) for histopathology examinations. IHC stained the other two sections to the markers mentioned earlier in the IHC technique. The results of IHC for MAP showed a highly significant relationship in the ileal tissues of patients with disease CD with varying degrees according to the intensity of the immune reaction, which represents the intensity of the color, which is distributed between weak, moderate and strong, according to the (Aperio image Scope) program. Where it was 10% weak, 43.33% medium, and 46.67% strong. The P-value for patients vs. control was 0.0052 and 0.0001, respectively (P-value 0 ≤ 0.01). The result of IHC proves the hypothesis of MAP as a potential cause of CD. The other effects of IHC staining for TWEAK/Fn14 marker showed a highly significant relationship in the ileal tissues of patients with Crohn's Disease with varying degrees according to the intensity of the immune reaction, according to the Aperio image Scope program. It was 10% weak, 36.67% medium, and 53.33% strong. P-value for patients vs control were 0.0003 and 0.0001, respectively (P-value 0 ≤ 0.01).
An overview of vaccine production against shrimp White Spot Syndrome Virus, effects and the possible impact of this technology in Ecuador
Authors: Proaño E. D. , Rivera L.M , Trujillo L. E.
Published: July 2023

Although aquaculture in Ecuador has a high economic and socio-cultural importance, pathogenic microorganisms affect the development and vitality of crustaceans, fish, and mollusks, reducing their production yields. Among these pathogens, White Spot Syndrome Virus (WSSV) is an invertebrate virus that induces high mortality, generating severe economic losses due to its wide geographical distribution and high infection rate finding the most significant devastation worldwide in the shrimp sector.

Although several strategies are described to fight against WSSV, this study points to an updated overview of vaccines used against this virus, including types, effects and large-scale production ways. Thus, this research supplies an analysis of possible treatments based on vaccination to combat the WSSV caused-disease that significantly impacts the aquaculture economy and could be helpful to those working in this field.

Keywords: Whispovirus, White Spot Syndrome Virus, Shrimp, virus, vaccine, production, Ecuador.
Caracterización de protocolos de ensayos clínicos de productos farmacéuticos radicados para evaluación regulatoria en Colombia: consideraciones bioéticas y metodológicas
Authors: Bello-Gándara Carlos J. , Vergara-Cano Erika , Osorio-Gallardo David , Recalde-Miranda Juanita M.
Published: July 2023

Los ensayos clínicos son esenciales para la evaluación de la seguridad y eficacia de productos farmacéuticos. Regiones emergentes como Latinoamérica han tenido un aumento en la ejecución de este tipo de estudios, tradicionalmente concentrados en países desarrollados. El propósito de este trabajo fue identificar las principales características con relevancia metodológica y bioética de los protocolos de ensayos clínicos de medicamentos presentados en Colombia ante la agencia regulatoria nacional. Se realizó un estudio observacional descriptivo, con base en el consolidado de los protocolos radicados al INVIMA y la información de EudraCT. Se incluyeron 597 protocolos, en los que se destaca el diseño aleatorizado (83,1%) doble ciego (66,7%), controlados por placebo (57,1%) y grupos paralelos (64,5%). Las enfermedades en investigación más frecuentes fueron neoplasias (22,8%). Se observó una baja representación de poblaciones vulnerables específicas como mujeres embarazadas (0,7%) o sujetos en situación de emergencia (2,4%) y escasas formulaciones especiales para población pediátrica (3,0%). La caracterización evidencia similitudes respecto al contexto regional y sugiere factores relevantes para evaluar y planificar protocolos en centros de investigación clínica.

Palabras clave: Características del estudio; Desarrollo de medicamentos; Investigación farmacéutica; Ensayos clínicos como tema; Protocolos de ensayos clínicos como tema.
Antifungal activity of metabolites from Trichoderma spp. against Fusarium oxysporum
Authors: M.F González , L Galarza , L.L Valdez , G.M Quizhpe
Published: July 2023

The Trichoderma genus is well known as one of the most valuable biological control agents against several phytopathogens used in different plant species. Managing phytopathogenic fungi using the Trichoderma genus through various associated antifungal mechanisms is a sustainable and eco-friendly strategy that reduces the harmful presence of pathogens in soil, roots and aerial parts of plants. However, using biocontrol agents combined with chemical pesticides has evidenced further potential to reduce pathogen growth and benefit plant development. A better characterization of active metabolites secreted by Trichoderma and their mechanisms of action is necessary to improve its use as a biocontrol agent. This review summarizes current evidence on Trichoderma spp., used as a biocontrol against Fusarium oxysporum, the active secondary metabolites secreted by the former fungi, and the effect of three widely used agrochemicals to control the latter, namely Mancozeb, Chlorothalonil, and Propiconazole. A total of 155 studies were selected and used to extract information that was analyzed, resulting in more than 590 identified secondary metabolites. Fifty-four percent of these have at least one biological function. Results highlight the potential of T. harzianum and T. reesei as biological control agents to control Fusarium oxysporum. The antifungal activity of T. Espirale is associated with enzymatic reactions. Additional findings show that management of diseases caused by F. oxysporum can be combined by using Trichoderma as biological control and agrochemicals to reach: (1) higher access to the different plant tissues; (2) higher degradation of the cell wall; and (3) and activation of oxidative metabolism of Trichoderma.

Keywords: Trichoderma, secondary metabolites, fungicide, mycoparasitism, biocontrol, Fusarium oxysporum
Miocardiopatía no compactada diagnosticada por Resonancia Magnética Cardíaca. Reporte de caso
Authors: Cevallos Ch Laura , Gudiño G Alvaro
Published: July 2023

La Miocardiopatía no compactada es una entidad rara, con una prevalencia no bien definida, caracterizada por un desarrollo anormal de la morfología miocárdica. Puede ocurrir en todos los grupos etarios, y su presentación clínica es variada, llegando a estar asociada a condiciones clínicas potencialmente mortales. El diagnóstico en la actualidad sigue siendo un reto, ya que no existe uniformidad de criterios y estos varían dependiendo de la técnica de imagen utilizada. A continuación, se expone el caso de una paciente femenina de 45 años de edad, con clínica de insuficiencia cardíaca, palpitaciones y eventos de presíncope. El estudio electrocardiográfico demostró una importante inestabilidad eléctrica y la resonancia magnética cardiaca hallazgos compatibles con miocardio no compactado.

Keywords: arritmias, cardiomiopatía, imagen por resonancia magnética, insuficiencia cardiaca
Pelestarian Kesenian Debus Banten di Padepokan Maung Pande
Authors: Yosef Calasanza  , Gunawan
Published: July 2023

Debus is one of the popular arts in Banten society. During the Banten kingdom, in the past Debus art became well-known. Initially, Debus became a medium for spreading Islam in Banten. During the colonial period, debus used against colonial troop. Debus perpetrators who are aware of their immunity to sharp weapons and bullets form a force to confront the colonial army. After independence, Debus developed into an art that is often staged in various events at the regional and national levels. However, recently its popularity has waned. Debus art is not much staged and known in the community. This circumstance has prompted Banten hermitages to promote and preserve Debus arts. This article aims to describe the activities of the hermitage in maintaining the existence of debus as well as activities to preserve the Banten debus art by Padepokan Maung Pande. The data collection method was carried out using qualitative research methods by focusing on data collection on member of the Maung Pande hermitage. The results of the study show that the conservation efforts carried out by the Maung Pande hermitage are carried out by collaborating with schools in Banten province.
Hermeneutika Dialogis sebagai Basis Filosofis dalam Fiksyen dan Sejarah, Suatu Dialog Karya Umar Junus
Authors: Suharmono
Published: July 2023

This study aims to explain dialogical hermeneutics, one of the scientific paradigms that can bridge the confusion of thinking in explaining the relationship between literature and reality/history. The material object used is Fiction and History of Dialogue, while the formal object is the dialogical hermeneutic paradigm in the book. The purpose of this study is to describe the basic assumptions; model; and the concepts that make up dialogic hermeneutics. The theoretical framework and method used as the basis for the analysis are Thomas Khun's thoughts related to paradigms. The results of the research show that Fiction and Dialogue History books criticize in discussing fiction which is dominated by mimetic and semiotic concepts as well as history which is seen as something that is often contrasted with fiction. Junus offers an alternative idea in the form of dialogue (hermeneutics) as a new way of looking at the relationship between fiction and history/reality. Junus uses an analogy model to see the relationship between fiction and history/reality. The concepts put forward include the Concept of Definition of Fiction; The Nature of Reality in Stories; Fiction and Heurmenetics; Fiction Shapes Reality; Perspective of Fiction and Reality of Writers and Readers; and Fiction and History.
Study on the Disaster Prevention Capacity of Residential Buildings in Enyang Ancient Town
Authors: Yating Peng
Published: July 2023

In the background of protecting the development of historical and traditional cultural buildings, the exploration of disaster prevention technology of ancient town buildings is of great significance. Enyang ancient town has a long history, and its residential buildings have typical Ming dynasty and Qing dynasty architectural features and regional characteristics of northeast Sichuan. Enyang ancient town has experienced many natural disasters such as floods and earthquakes in its history, and the disaster resistance of its residential buildings is worth exploring. Taking the dwellings in Enyang Ancient town as the research object, its architectural space form and architectural structure are analyzed. On this basis, the flood resistance, earthquake resistance and fire resistance of the ancient town’s residential buildings were further studied. The research results can provide reference for the analysis of disaster prevention performance and reinforcement protection of similar ancient towns.
SPECTROPHOTOMETRIC FINGERPRINTING AND CHEMICAL DETERMINATION OF STREPTOMYCIN, AMIKACIN, NEOMYCIN, AND GENTAMYCIN SULPHATE BY CONDENSING WITH NINHYDRIN REAGENT
Authors: VAIKOSEN EDEBI N. , BUNU SAMUEL J. , DODE EBIERE , EFIDI RUTH B.
Published: July 2023

Objective: The study aimed to develop a simple, efficient, inexpensive, rapid, and reproducible spectrophotometric analytical technique for aminoglycosides analysis by condensing with ninhydrin reagent.
Methods: At a pH of 8.0, different aminoglycosides, including amikacin, gentamycin, neomycin, and streptomycin, were deaminated by the ninhydrin reagent. The working standard solution for each component was accurately placed into a series of 10 ml calibrated volumetric flasks, then 1 ml of the ninhydrin reagent was added and heated in a water bath for 15 min. The wavelength(s) of maximum absorption(s) was recorded after scanning the resultant purple complex from 350 nm to 930 nm. The final working concentrations ranged between 1600 and 2000 ug/ml.
Results: The average weight of a neomycin sulphate tablet was 0.747g, with a standard deviation of 0.667%. After complexing with ninhydrin reagent at pH 6.0 for 10 to 15 min, all aminoglycosides developed purple coloration that lasted beyond 24 h, compared to the initial white, pale yellow, and colorless appearance of streptomycin, amikacin, neomycin, and gentamycin, respectively. The scanned spectra of the purple complex of ninhydrin formed after reaction with aminoglycosides in the visible region (350-900 nm) were similar, indicating the presence of a common parent structural moiety. At 550 nm, 650 nm, 750 nm, and 850 nm, distinct absorptions were observed. Amikacin, Streptomycin, and Gentamicin had the highest absorbance between 800 and 900 nm. After the reaction with ninhydrin, three distinct absorbances were observed in the Neomycin spectrum: between 380 and 400 nm, 580 and 600 nm, and around 800 nm. The comparative spectra for the four aminoglycosides and ninhydrin reagent with blank show a unique feature for the compounds. The coefficients of regression were 0.996 and 0.995, respectively.
Conclusion: The proposed methods for analyzing streptomycin in streptomycin injections were successful. The percentage purity ranged from 017–110 % at 650 and 850 nm, which corresponds to the British Pharmacopoeia (BP) limit that streptomycin sulphate tablets should be between 97.00 and 110%.
THE IMPACT OF COVID-19 PANDEMIC ON VARIOUS STRESS FACTORS AND ITS CORRELATION WITH HAIR FALL: AN ONLINE-BASED SURVEY AMONG BANGLADESHI RESIDENTS
Authors: SHAHED MEHEDI HASAN , TASNEEM SAMIA , SULTANA HABIBA , WAHED IMAM IBNE , KUNDO NETISH KUMAR , ALI MD ASHRAF
Published: July 2023

Objective: The COVID-19 pandemic has triggered several stress factors throughout the entire world. Some stress factors, such as mental, economical, educational etc., have created consequences like hair fall, as seen in individuals in many countries, including Bangladesh. The present study was designed to investigate the covid-19-induced stress factors and their relation with hair loss in the people of Bangladesh.
Methods: An online-based survey study was carried out using a self-made questionnaire, and quantitative data were analyzed by a cross-sectional analysis over the period of two months from November 25, 2020, to January 24, 2021. Participants who were willing to participate into this survey were considered as study individuals. This survey was conducted among participants with age’s ≥18 y. The participants were selected by snowball sampling technique, and the final collected sample size was 808.
Results: Among 808 participants, males and females were 50.3% (406) and 49.7% (402), respectively. We found that 5% (37) participants were infected with Covid-19, 89% (715) were not infected, and 7% (56) were unknown. It is found that COVID-19-induced stress conditions including educational 28%, mental 25%, and economical 20% were found in 81% (655) participants and rendered 68% (550) people facing the hair fall problem due to COVID-19-related stress. Female individuals who were more stressed were 74.6% (300) and had hair fall, whereas males were 38.7% (157). In addition, the increased rate of hair fall in COVID-19 is associated with other factors, such as eating disorders and scalp infections, as reported by some respondents.
Conclusion: In pandemic situations, most of the people (81%) passed through the stressful condition, and the females experienced more hair fall problems than male one. High blood pressure, eating disorder and irregular sleep pattern are considered stress-induced factors that were responsible for increased hair loss.
A pergunta no gênero entrevista com presidenciável: articulando gramática, texto e contexto
Authors: Cunha Gustavo Ximenes
Published: July 2023

Adotando o pressuposto segundo o qual gramática, texto e contexto são indissociáveis, propomos um estudo sobre a pergunta no gênero entrevista com presidenciável. Centrando-se no estudo da linguagem verbal, analisamos as perguntas realizadas pelos entrevistadores na entrevista concedida pelo então candidato à presidência da República, Luiz Inácio Lula da Silva, ao Jornal Nacional, da Rede Globo, em 25 de agosto de 2022. Nosso objetivo central é o de estudar as funções que as perguntas realizadas pelos entrevistadores exercem nessa entrevista. Com base em contribuições teóricas de perspectivas funcionalistas e interacionistas, constatou-se que os entrevistadores, nas 34 perguntas identificadas, realizam dois tipos de perguntas: as que iniciam trocas e as que não iniciam trocas. As que iniciam trocas apresentam uma complexidade elevada, em razão do fato de que, nos turnos em que ocorrem, o jornalista alcança a completude pragmática por etapas, como explicação do tópico, desenvolvimento do tópico e, finalmente, realização da pergunta. Já as perguntas que não iniciam trocas constituem reformulações da pergunta inicial, aquela com que o jornalista iniciou a troca. Essas perguntas caracterizam-se por apresentar uma concentração elevada de recursos verbais com que o jornalista assume uma postura antagônica em relação ao entrevistado e reivindica uma primazia epistêmica em relação a este.
“Com isso” e “com isto”: uma análise funcional centrada no uso
Authors: Da Silva Simone Josefa
Published: July 2023

Partindo dos resultados obtidos em Silva (2022), este artigo visa a ampliar os estudos sobre a construção conectora [com isso], fazendo uma análise comparativa entre [com isso] e [com isto]. Para tal, a análise fundamenta-se nos pressupostos teóricos da Linguística Funcional Centrada no Uso (CROFT, 2001; GOLDBERG, 1995, 2006; TRAUGOTT e TROUSDALE, 2021; ROSÁRIO e OLIVEIRA, 2016; LOPES, 2022) em interlocução com os estudos da Linguística Sistêmico-Funcional (HALLIDAY, 2004), da Pragmática (SWEETSER, 1990) e da Linguística de Texto (cf. KOCH, 2004; FÁVERO, 2004). A pesquisa é feita com base em uma abordagem sincrônica, qualitativa e quantitativa. O banco de dados é composto de ocorrências extraídas do Corpus Now, do site Corpus do Português (www.corpusdoportuguês.org). Análises preliminares apontam que [com isso] e [com isto] atuam de modo semelhante no que diz respeito às relações coesivas promovidas, sendo a primeira construção mais produtiva no português brasileiro e a segunda, no português de Portugal.
IoT and Wireless Sensor Network Based Autonomous Farming Robot
Authors: M Sowmya
Published: July 2023

Abstract: In recent years, there has been an increasing demand for smart farming solutions to optimize crop production while reducing the need for manual intervention. Internet of things (IoT) is an emerging technology that shows the future of computing and networking. Agricultural monitoring from a remote location is one of the essential applications of IoT based wireless sensor networks. The IoT based wireless sensor network faces problems due to the dynamic changes in the environment. The number of required sensor nodes increases for monitoring of the vast area. By introducing mobility of all nodes in the IoT based wireless sensor network, we can decrease the number of nodes and thus reducing the cost of the overall system. In this project, an IoT based farming robot network is proposed for farming applications. Robots are also equipped with an infrared sensor for avoiding obstacles during navigation. We developed automatic plant watering system also. These robots can be used for harvesting pesticide spraying, controlling weed and many other applications. The proposed system provides an efficient and cost-effective way to manage crops, while reducing the need for manual labor.
Stress Detection using Deep Learning Techniques
Authors: Jyothi Ms. A. Aruna
Published: July 2023

Abstract: Stress is a typical component of daily life that has an impact on people in different circumstances. However, sustained or acute stress can negatively impact our health and interfere with our daily activities. Early recognition of mental stress is essential for good management and the avoidance of future health problems brought on by chronic stress. Understanding the connection between facial expressions and the accompanying emotional experiences of individuals is a topic of great interest. According to research, facial expressions and indications might offer important clues for the study and classification of stress. Notably, changes in the mouth and eyebrows are important signs of stress on the human face. This technology records live video and applies conventional conversion to capture stress levels. In order to analyse the user's stress levels, this system records live video and uses conventional conversion and image processing techniques. The technology provides more precise and effective results in stress prediction by utilising machine learning algorithms that concentrate on brow and lip motions.
Diabetes Insipidus: Diagnosis, Pathogenesis, and Management
Authors: Bhadouria Aashi Singh , Bhadouria Ishan Singh
Published: July 2023

Abstract: The inability to control one's own urine output due to diabetes insipidus (DI) is a serious medical condition that may affect a person at any age. Constant urine and thirst, particularly during sleep, might disrupt your sleep cycle. The researchers behind this study searched the PubMed database for any and all relevant publications on DI. Nephrogenic DI, which results from the kidney's inability to respond to arginine vasopressin (AVP), is often inherited, but central DI, which results from the brain's inability to produce enough AVP, might result from trauma, surgery, or tumours. Historically, treatments have included the administration of oxytocin and vasopressin-containing extracts from the posterior pituitary. In comparison to vasopressin, the synthetic vasopressin counterpart desmopressin has some benefits. Desmopressin in intranasal form was the first to market, but since then, oral tablet and melt versions have gained favour due to their ease. Amiloride, thiazide diuretics, indapamide, clofibrate, indomethacin, carbamazepine, and chlorpropamide are some more medicinal compounds. However, desmopressin remains the medicine of choice for treating DI. The review discusses desmopressin-targeted medicines, DI precipitants, and the physiology of water balance
Technology simulation training in the production of drug tablets for pharmaceutical vocational school students in Bekasi City
Authors: Anindita Reza , Beandrade Maya Uzia , Putri Intan Kurnia , Nathalia Dede Dwi , Perwitasari Melania
Published: July 2023

One of the most dominant types of preparations used by the public is tablets. This community service and empowerment (CSE) aims to introduce and provide training on making tablets with innovative tablet printing machine technology in the pharmaceutical industry and to build partners with SMKs to provide access to education for the vocational level by science and technology while at the same time offering a scholarship program as access to continuing higher education at STIKes Mitra Keluarga for high achieving and financially disadvantaged students. This CSE method includes planning carried out by making an offer to the Pharmacy Vocational School in Bekasi City and making activity flyers to be distributed for class 12, 10, and 11. The implementation was carried out by giving pre-tests, materials, and simulation practices for making drugs with tablet printing machines at STIKES Mitra Keluarga. The evaluation stage is carried out by giving post-test questions. Data analysis in this study was carried out using descriptive and comparative tests using paired t-tests. The results of this CSE show that the value of knowledge and understanding of 35 students before being given material treatment and training was 57 and after being given treatment it was 94 with a percentage increase of 43%. Therefore, this CSE activities is able to increase the knowledge and understanding of 35 class X, XI and XII students of the Bakti Kartini Pharmacy Vocational School regarding making medicine using a tablet printing machine in a real way.
Improvement of students’ creative writing literacy at SMPN 16 Malang
Authors: Iswatiningsih Daroe , Widodo Joko , Sutawi S. , Winarsih Anis Dwi , Wediya Prilla Lukis
Published: July 2023

The objective of the community service carried out by a team from Universitas Muhammadiyah Malang at SMPN 16 Malang is to increase students’ creative writing literacy. The methods used were training and mentoring during creative writing. The activity began with recording students’ writing interests and identifying the students' type of writing preferences, followed by training, writing practice, evaluating student work, strengthening student understanding, and improving the written work. To achieve the activity’s targets, students were requested to answer questions on a Google form. The result shows that 178 students have an interest in writing, of which 79% chose to write stories, 19% wrote poetry, and the rest chose fables and history. Students who were interested in writing were given training and practice. The training includes strengthened writing concepts, writing practice, result assistance, and feedback. Training activities, mentoring, and enhancement of student work are carried out for three months. Furthermore, the process of editing and designing the book was carried out for one month. At the end of the activity, 78 students could write short stories, descriptive stories, and poetry. After going through the curation and editing process, the students' work was recorded with an International Standard Book Number (ISBN) and given to each author and the school.
Group mentoring of youth scientists to enhance the students’ research literacy
Authors: Fauzi Ahmad , Waluyo Lud , Fatmawati Diani , Zubaidah Siti , Sukrisno Sitaresmi Weka , Azizah Nafisa Nur
Published: July 2023

The Youth Scientific Group (YSG) is an extracurricular activity that has a positive impact on students. Unfortunately, the presence of YSG in various schools, including SMAN 1 Tumpang, is still not optimal. In this high school located in Malang Regency, the YSG activities have not been carried out consistently. The scientific competence and research literacy of students at SMAN 1 Tumpang have not been fully utilized. In response to this issue, the aim of the Community Science and Technology Program (Community Service Program) is to enhance the scientific competence and literacy of students at SMAN 1 Tumpang through mentoring in the preparation of YSG. This Community Service Program consists of several stages, including observation and problem identification, preparation of YSG mentors, material presentation, training and mentoring, activity evaluation, and the preparation of scientific articles as program outputs. The average pretest score of the students' knowledge was 39.67, while the posttest score increased to 93.23. The average N-gain of their knowledge reached 0.836. Based on this N-gain value, the students' knowledge improvement is categorized as high. The paired t-test results indicate a significant difference in students' knowledge related to scientific work before (M = 39.7, SD = 20.6) and after the program (M = 93.2, SD = 7.5), t(30) = 14.6, p < .001. Therefore, the program implemented in the partner school has proven to be beneficial in enhancing students' scientific competence.
Optimizing honey production in stingless bee farming
Authors: Priyambodo P. , Rustiati Elly L. , Permatasari Nindy , Sidik Mahfud , Lestari Indah A. , Yani Ani A. , Sa'uddah Lousanja D.
Published: July 2023

Harapan Jaya Village, Way Ratai Subdistrict, Pesawaran Regency has very promising potential for cultivating trigona bees. Lecture and student from University of Lampung team conducted training on stingless bee cultivation in this village in 2022. At the end of 2022, several stingless bee colonies experienced deaths that were allegedly due to lack of nectar sources. This community service activity was carried out to provide understanding and training on vegetation management and adding stingless bee colonies. Activities are carried out with lectures, discussions, and hands-on practice. The results of the activities that have been carried out include the addition of seven types of nectar source plants and two stingless bee colonies. In addition, the community's understanding of the maintenance of stingless bee colonies and their supporting vegetation also increased.  This is very supportive of long-term programmed in the achievement of SDGs, especially in the goals of life on land and no poverty.
REFLECTION OF THE GREAT PATRIOTIC WAR IN RUSSIAN HISTORY TEXTBOOKS IN THE FOCUS OF HISTORIOGRAPHY
Authors:   Saint Petersburg State University (Russia), Antipov A.M.
Published: July 2023

This article discusses the current state of the study of history textbooks, presents a historiographic review of materials on the coverage of the Great Patriotic War in the history textbooks of Russia in 1992–2020. In the modern world, textbooks, teaching aids and school programs are the key instruments of the state politics of memory. The Great Patriotic War has become one of the central objects of the historical memory of Russian society and one of the pillars of Russian identity, and therefore is actively used in all of the above tools of education and politics of memory. Two main areas of study of textbooks are singled out - as educational and as ideological texts. The ideological views of researchers and their own attitude to the Great Patriotic War and World War II, memory and politics of memory about them are revealed, which can be attributed to “patriotic”, “liberal” and corresponding to Western academic discourse. The assessment by scientists of textbooks of different years is considered, it is established that Russian textbooks received mixed, mostly positive assessments. Evaluation of textbooks depends on the ideological views of the scientist. The obvious insufficiency of studying the new line of domestic textbooks (after 2016) is noted, as well as the methodological limitations of the approaches to the analysis of educational texts existing in the literature. Such a study should combine the methods of narrative analysis and discourse analysis, pay attention to the methods of constructing historical myths and direct falsifications.
UPPER VOLGA REGIONS AND INTERREGIONAL COOPERATION IN THE USSR (1960-1980S)
Authors:   Yaroslavl State Pedagogical University named after K. D.Ushinsky (Russia), Nikiforov Yu. S.
Published: July 2023

The central concept of the study is interregional interaction. The article discusses the main forms of interregional cooperation in the late USSR. The interregional cooperation of the institutions of power in the USSR in the 1960s-1980s is analyzed. The features of interregional communication of the leading personnel of the Upper Volga regions of the RSFSR (Ivanovo, Kostroma, Yaroslavl) are studied. Attention is paid to the consideration of significant "horizontal" links ("region-region" line) in interregional interaction. The corpus of sources includes declassified archival documents from the State Archives of the Ivanovo Region (GAIO), the State Archives of Contemporary History of the Kostroma Region (GANIKO), official regulatory documents, data from oral history and scientific literature. The article states that in the 1960s-1980s. there was an increase in interregional communication based on production chains. It is emphasized that there was an increase in contacts between the Upper Volga regions and various regions of the USSR, including the union republics (Belarus, Uzbekistan, Ukraine). It is concluded that the interregional interaction of the Upper Volga regions was influenced by three factors: economic, ideological, personal.