bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical profiles and causes of ascites in children at a tertiary care hospital, Bangladesh
Authors: Mazumder Wahiduzzaman , Roy Urmy , Raihan M. Farid
Published: March 2024

Background: Ascites is an accumulation of serous fluid within the peritoneal cavity. Combined analysis of laboratory data and clinical and pathological details are essential for establishing a differential diagnosis. In children of Bangladesh our context, etiologies behind ascites are not yet studied well. The aim of our study was to evaluate the causes of ascites in the basis of clinical feature and laboratory investigation in children.
Methods: This was a cross-sectional retrospective descriptive hospital-based record review of a tertiary center of hospital, Bangladesh. All children aged between 6 months to 17 years with ascites, irrespective of their primary cause admitted in pediatric ward were included in this study. The study was conducted during September 2019 to September 2020. During this period, 50 children presented with ascites were enrolled in the study.
Result: The mean age was 8.174. The age range of the patients was from 6 months to 17 years. Twenty-eight (56.0%) of them were males and 44% of the participants were female. Maximum 54% have duration more than 7 days. The most common previous symptoms were fever (68%) and jaundice (38%) followed by bleeding manifestation (30%). The most common etiology of ascites was Chronic liver disease with portal HTN (48%), followed by abdominal tuberculosis (14%).
Conclusion: This study found that CLD with Portal HTN is the most common cause of ascites in pediatric age group and second most common cause is infectious cause e.g. abdominal tuberculosis. This also highlighted that the presenting symptoms and laboratory parameter that guided to find out the causes of ascites.
COVID-19 pandemic: maker or breaker for families having children with autism spectrum disorder-case series of maternal experiences, strategies and suggestions
Authors: Inamdar Nusrat R. , Wade Minal R. , Mauskar Anupama V.
Published: March 2024

The COVID-19 pandemic due to prioritization of emergency and COVID-19 patient care at hospitals and disruption of daily routines and finances, impacted significantly families having people with special needs. This case series highlights the problems faced and strategies used by mothers of children having autism spectrum disorder (ASD). It summarizes the experiences of nine families of ASD children (2 to 9 years), selected consecutively from pediatric developmental/disability outpatient department (OPD) of a tertiary care center during i.e. April 2021 to May 2021 (2nd wave of COVID-19 pandemic) using a pre-designed proforma. Socio-demographic details, maternal experiences about challenges faced in child’s home care, special therapies, managing child’s behaviour, family support system, adaptations and their suggestions were recorded. The age group was 2 to 9 years and 8 were males. 7 out of 9 mothers reported that their child’s interaction with father and other family members improved. Institutional therapy was discontinued by all mothers. Two mothers reported increased aggression in the child. Mothers from joint family and having supportive families reported less stress. Children who had company of parents/grandparents/sibling and availability of indoor games, art and craft and storytelling, reported less screen time and less behavioural disturbances though all the mothers reported increased screen time compared to pre COVID times. Mother’s empowerment is key to success. Indoor physical games, unstructured play, increasing social awareness, supportive families, tele-rehabilitation services can improve overall progress in ASD children. Health care practices need to be revised from time to time for special needs/situations.
Gum hypertrophy in acute myeloid leukemia: an important clinical finding not to be missed
Authors: Narendran Harshita , Gaddam Sudeep , Shanmugam Vimalnath , Jayaraman Dhaarani , Shanmugam Sri Gayathri , Sneha Latha M. , Scott Julius Xavier
Published: March 2024

Acute myeloid leukaemia (AML) is characterized by disordered differentiation and proliferation of abnormal hematopoietic stem cells. AML usually presents with symptoms of anemia like pallor and fatigue, recurrent infections, petechiae, and mucosal bleeds. Extramedullary infiltration of leukemic cells is a common finding like proptosis or myeloid sarcoma. The occurrence of gingival hypertrophy in the pediatric age group is uncommon and usually due to inflammation followed by prolonged use of certain drugs like cyclosporin or phenytoin. Gingival infiltration in AML is rare in children, usually associated with subtypes M4/M5 (FAB classification). This case report highlights the importance of considering AML as an important differential diagnosis in cases of gum hypertrophy, as being a less common cause, it is often overlooked. Timely diagnosis and prompt treatment can be lifesaving. Here, we report two cases who presented with gum hypertrophy.
Evaluation of chemical composition of root canal dentin between two age groups using different irrigating solutions: An in vitro sem-eds study
Authors: K Naresh Kumar , Kallu Abhijith , L.R Surender , Nirmala Sravani , Reddy Narender
Published: March 2024

The study aimed to evaluate and compare the effect of different irrigating solutions on the chemical composition of root canal dentin between two age groups.

Sixty-six extracted single rooted human premolar teeth were decoronated and longitudinally sectioned to expose canals. Root halves were divided into 2 groups and 3 sub-groups based on the irrigation protocol. Samples were evaluated for mineral content with Scanning Electron Microscope/Energy Dispersive Spectroscopy (SEM/EDS). The data were analyzed statistically.

Results revealed a statistically significant difference in calcium levels of younger age group, with higher levels for SmearClear (19.1±1.31) when compared to MTAD (Mixture of Tetracycline Isomer, Acid and Detergent) (17.1±1.16), with p value 0.01. A statistically significant difference was observed in magnesium levels of younger age group, with higher levels for MTAD (0.95±0.21) when compared to SmearClear (0.82±0.22), with p value 0.05. Mean comparison of Ca/P ratio of younger age group, revealed higher values for SmearClear (1.71±0.14) when compared to MTAD (1.56±0.15), with p value 0.02.

MTAD caused significantly greater loss of calcium, phosphorous, sodium and altered Ca/P ratio of root dentin among younger age group. On the other hand, loss of magnesium content was found to be higher within SmearClear sub group of younger age group (p=0.05).
Diagnóstico institucional do serviço público na América Latina: Brasil 2024
Authors: Drumond Felipe
Published: March 2024

O presente diagnóstico descreve os resultados da avaliação do serviço civil do Brasil, realizada em 2023. Fundamentou-se no quadro metodológico elaborado em 2002 e nas boas práticas descritas na Carta Ibero-Americana da Função Pública (CLAD; ONU, 2003), que todos os países da América Latina subscreveram como o padrão ao qual a gestão do serviço civil deveria se orientar. O quadro metodológico foi aplicado na avaliação de 22 países da América Latina e do Caribe entre 2002 e 2005, incluindo o Brasil. O relatório de situação do serviço civil deste país, concluído e publicado em 2014, constitui a linha de base com a qual são comparados, no presente diagnóstico, os avanços e os desafios ainda pendentes em termos de profissionalização do serviço civil.
Requirement patterns in deductive verification of poST Programs
Authors: Chernenko Ivan M. , Anureev Igor S. , Garanina Natalia O.
Published: March 2024

Process-oriented programming is one of the approaches to developing control software. A process-oriented program is defined as a sequence of processes. Each process is represented by a set of named states containing program code that define the logic of the process's behavior. Program execution is sequential execution of each of these processes in their current states at every iteration of the control cycle. Processes can interact through changing each other's states and shared variables.

The paper expands a method for classifying temporal requirements for process-oriented programs in order to simplify and automate the deductive verification of such programs. The method consists of the following steps. At the first step, the requirements are formalized in a specialized language DV-TRL, a variant of typed first-order predicate logic with a set of interpreted types and predicate and functional symbols, that reflect specific concepts of control systems in a process-oriented paradigm. At the second step, the formalized requirements are divided into classes, each of which is defined by a pattern — a parametric formula of the DV-TRL language. The correctness conditions generated for process-oriented programs regarding requirements satisfying the same pattern have the same proof scheme. At the third step, appropriate proof schemes are developed.
In our paper, we first give a brief introduction to the poST language, a process-oriented extension to the ST language of the IEC 61131-3 standard. Next, the DV-TRL language is defined. We also provide a collection of natural language requirements for several control systems. Then we define patterns that fully cover all the requirements of this collection. For each of these patterns we give an example of a formalized requirement from the collection and describe a scheme for proving the correctness conditions for this pattern. Statistics on the distribution of requirements from the collection across patterns reveals the most popular patterns. We also analyzed related works.
The structure of the phenomenon of aggressiveness of convicted men in their supra-situational self-determination
Authors: Lopatina Nadezhda V.
Published: March 2024

The article is devoted to the study of the relationship between aggression, the peculiarities of supra-situational self-determination of men serving their sentences for the first time and the current year of their sentence. The main result of the work is the proof of the existence of a special dynamics of the structural organization of the studied parameters, characterized by its wave-like character.
Russian civil society of wartime: the specifics of development in the conditions of Special military operationa
Authors: Tsybakov Dmitry L.
Published: March 2024

The purpose of the article is to study the trends and features of the development of civil society in the Russian Federation in the process of a special military operation in the regions of historical Novorossiya. It is noted that the influence of ITS on the functioning of the Russian model of the «third sector» leads to fundamental transformations of the nature of the state-civil dialogue. It is argued that the field of civil-military relations is becoming a priority area of interaction between society and the state in modern Russia. As evidence, examples are given of an increase in the composition of non-governmental structures both in the direction of their activities and in spreading to the lowest level of territorial and political organization. It is proved that the priority task of the vast majority of newly emerged and previously existing public entities is to provide some kind of support to units and units of the Russian army in theaters of armed struggle, as well as social protection of military personnel and their family members. For a very limited time period, institutionalized and networked associations en masse include all new social aggregations and territorial communities, which became the organizing link of the national patriotic upsurge during the period of their independence. It is predicted that those actors who have been able to prove themselves as a link between the army and the people will be able to act as a core component of civil society in Russia of the 21st century in the foreseeable future.
Student Associations as a Tool for Developing the Human Capital of Youth
Authors: Ivchenkov Sergey G. , Ivchenkova Maria S.
Published: March 2024

Russian student youth has become an important segment of state policy with a focus on creating conditions for the development of the younger generation, including within the university framework. The article presents the results of a sociological survey conducted through a questionnaire in 2023. A quota sample of 490 students of Saratov State University was surveyed. The influence of the specifics of the student association on the activities and the quality of the students' human capital is clearly traced. In the process of participating in student associations, youth gain valuable practical experience which can be used to capitalize on social capital in their future. However, most students are satisfied with their involvement in their respective associations but see drawbacks, such as time constraints, interference with studies, and to some extent, in job searching. It has been confirmed that goal-setting as a design competence of students is weakly developed, requiring special attention from the university. Ladies are more focused on realizing their talents, developing organizational abilities, and initiative, but often note that this activity interferes with their studies. Young men value more the development in associations of such qualities as responsibility, creativity and determination. However, they are more likely to be active for the company and feel a greater sense of time pressure. The students' age also plays an important role. The older the student, the more actively he realizes the potential gained in the association to find a job.
Halucynacje chatbotów a prawda: główne nurty debaty i ich interpretacje
Authors: Kreft Jan , Boguszewicz-Kreft Monika , Cyrek Barbara
Published: March 2024

Generatywne systemy sztucznej inteligencji (SI) są w stanie tworzyć treści medialne poprzez zastosowanie uczenia maszynowego do dużych ilości danych szkoleniowych. Te nowe dane mogą obejmować tekst (np. Bard firmy Google, LLaMa firmy Meta lub ChatGPT firmy OpenAI) oraz elementy wizualne (np. Stable Diffusion lub DALL-E OpenAI) i dźwięk (np. VALL-E firmy Microsoft). Stopień zaawansowania tych treści może czynić je nieodróżnialnymi od twórczości człowieka. Chatboty cechują się jednak tzw. halucynacjami, które w istotnej części są nowym rodzajem dezinformacji. Celem podjętych badań jest identyfikacja głównych nurtów debaty poświęconej skutkom wykorzystania sztucznej inteligencji ze szczególnym uwzględnieniem dezinformacji z udziałem chatbotów w środowisku mediów. W badaniu przyjęto metodę badawczą systematycznego przeglądu literatury ograniczającą m.in. błąd selekcji. Interpretacja głównych nurtów debaty skłania do wniosku, że dezinformacja chatbotów w postaci ich halucynacji jest znacząca pod względem skali, jest optymalizowana i personalizowana oraz ma istotny potencjał erodowania zaufania społecznego.
Anais do VII Fórum Internacional de Diálogos e Práticas Interprofissionais em Saúde (FONDIPIS)
Authors: Unida Rede
Published: March 2024

Destaca-se que o DOI para todos os resumos é o DOI geral da edição. DOI: 10.18310/2446-4813.2024v10nsup1
Study of Acceptance Rate, Compliance and Complication of H1N1 Seasonal Vaccine among Health Care Workers
Authors: Dugad Sushama , Bhandare Pankaj , Sundrani Ramesh , Kulkarni Gauri , Patil Nilesh
Published: March 2024

Background: Our knowledge on reasons of non-acceptance and complication to H1N1 Vaccination by health care workers is limited. A better understanding of factors having significance in vaccine acceptance is crucial. With this background in mind present study was conducted at tertiary care centre to determine the Acceptance, Compliance, and Complication of anti-H1N1 seasonal vaccine among Health Care Workers (HWCs). Materials and Methods: Prospective Observational study was conducted to observe the rate of acceptance, compliance and complications of anti H1N1 seasonal vaccine among 100 health care workers in the period of December 2015 to December 2017 in Tertiary Health Care Centre. All participants were counselled 3 times at interval 6 months (0, 6, and 12 months) regarding H1N1 vaccine. Result: Vaccine acceptance rate among health care workers was only 03% before counseling. The main cause for not acceptance of vaccination was fear of adverse effects reported by 27% health care workers followed by cost of vaccine (12%) and work pressure (10%) or nonavailability of time. Conclusion: As counseling sessions progressed health care workers also started accepting vaccination. After completion of third counseling session rate of vaccine acceptance increased from 3% to 71% and also negative and doubtful conception of health care workers were and changed completely. After counseling their knowledge regarding influenza vaccine was increased. Even though some post vaccination complications had been reported by recipient; those symptoms lasted for short duration of time and there was no serious adverse effect of H1N1 vaccine.
Effectiveness of Mindfulness Group Training Based on Stress Reduction on Emotional Self-Regulation and Self-Care in Diabetes Type 2
Authors: Aqebati Mohammad Reza , Shabani Jafar
Published: March 2024

Objective: This study was conducted to investigate the effectiveness of mindfulness group training based on stress reduction on emotional self-regulation and self-care in type 2 diabetes people - Esfrain 2023.
Materials and Methods: This is an experimental research with a pre-test and post-test method and a control group. The statistical society included all type 2 diabetes people in Esfrain city, of whom 36 people were selected as the study sample. The participants were simple random placed in an experimental group and a control group. The experimental group received mindfulness group education based on stress reduction during eight 2-h sessions over 8 weeks, whereas the control group received no education. Before and after the education sessions, the two groups completed Hoffman and Kashdan’s (2010) emotional self-regulation questionnaire and Tobert and Glasso’s (2000) self-care questionnaire. Data were analyzed using the multivariate analysis of covariance test.
Results: The results showed that mindfulness group training based on stress reduction can improve emotional self-regulation scores and life expectancy in patients with type 2 diabetes(P: 0.0005).
Conclusion: According to the results of the research, mindfulness training based on stress reduction is suggested to diabetic patients as a complementary treatment with the aim of improving the level of emotional self-regulation and self-care.
Effect of High-Intensity Interval Training on TCF7L2 Gene Expression in Hepatocytes of Obese Rats
Authors: Karimy Akbar , Kazemzadeh Yaser , Eizadi Mojtaba , Sedaghaty Saeid , Ghotnian Sepideh
Published: March 2024

Objective: Hepatic glucose release is greatly increased in the presence of obesity and related diseases. The research objective was to explore the impact of high intensity interval training (HIIT) on TCF7L2 gene expression in hepatocytes of obese rats.
Materials and Methods: Out of 21 male Wistar rats aged 10 weeks years (220±10 g), obesity was induced in 14 rats by 8-week high-fat diet. The rats were then divided into normal (n=7), obese control (n=7), and HIIT obese (n=7) groups. Rats in the HIIT group completed 8 weeks of HIIT/5 days weekly, whereas the other groups were inactive. After intervention, TCF7L2 gene expression in hepatocytes, insulin resistance and glucose compared using ANOVA /Tukey’s post hoc test between groups by SPSS-22.
Results: Obesity induction led to a significant decrease in TCF7L2 gene expression (P: 0.011) and an increase in blood glucose (P: 0.009) and insulin resistance (P: 0.019) compared with the normal group (P< 0.001). On the other hand, interval training led to a significant increase in TCF7L2 gene expression (P: 0.029) and a decrease in blood glucose (P< 0.001) and insulin resistance (P< 0.001) in the obese group compared with the control group.
Conclusion: The observed enhancement in fasting blood glucose levels among obese rats could be linked to increased TCF7L2 gene expression in liver cells, which appears to be a response to interval training intervention. Nevertheless, understanding the main mechanisms responsible for observed changes requires further studies in this field.
Isolation of Dark Septate Endophyte (DSE) from Ferns (Pteris Vittata) Roots
Authors: Sukmawati Dalia , Thaharah Alza Kirana , Komariah Esti , Herawati Herawati , Theodora Vicky , Supiyani Atin , Al Husna Shabrina Nida , Ratnaningtyas Nuniek Ina , El Enshasy Hesham , Dailin Daniel Joe
Published: March 2024

Dark Septate Endophytes (DSE) are a group of ascomycetes that live in intracellular and extracellular root tissue to facilitate plant growth and stress tolerance in extreme environments. However, little is known about the DSE fungi isolated from certain plant roots such as Pteris vittata, especially under drought condition. Pteris vittata is known for its ability to live in various types of substrates and ecosystems. In this study, we obtained DSE fungi from the fern roots Pteris vittata collected from the area of Universitas Negeri Jakarta. DSE isolation was carried out by inoculating the Pteris vittata fern roots with a size of 0.5 cm on the surface of sterilized PDA media for 5-7 days at 27∘C. Observations were made every 24 hours using a stereo microscope to see the first hyphae appeared from the plant roots. The results exhibited 13 samples of roots with hyphae colonization and were suspected to be DSE fungi. Of the 13 root isolates, only 3 isolate (PP2, PP4A, and PPB) showed the DSE growth (23%) with melanin pigment. The morphological characteristics of endophytic DSE fungi collected from Pteris vittata roots represented septate hyphae, brownish to black colony color, a growing zone, and a velvety texture. For the isolate PP2, it showed sclerotia while for the isolate PP4, it exhibited light brown colonies.
Keywords: isolation, DSE, ferns, pteris vittata, roots
Analysis of Macroalgae Diversity in the West Coastal of Pananjung Beach, Pangandaran
Authors: Irpan Aip Muhamad , Kurniasih Surti , Sutjihati Susi , Lathifah Suci Siti , Anugrah Resmilia , Aqila Siti , Alfieansyah Muhamad
Published: March 2024

The needed information about the diversity data in the area that can be used in ecological areas in the future is requested to be investigated. This study aims to analyze the diversity of macroalgae on the west coast of Pananjung beach, Pangandaran nature reserve. The study was conducted from March to April 2020. This research used a survey method using three stations representing the research region. Sampling was taken out in the intertidal zone of the Coastal Coast of West Pananjung, Pangandaran nature reserve, West Java using the purposive sampling method. Data taken consisted of macroalgae types found at each observation station and measurements of environmental data consisting of pH, temperature, salinity, and flow velocity. The results showed that there were 21 species of macroalgae grouped into 9 orders, 13 families, and 3 divisions. The research can conclude that macroalgae in Pananjung Barat Beach Pangandaran have an index value that indicates a moderate category, an evenness index classified as a low category, and a dominance index classified as a low category that shows the dominant species was there and it was Padina australis.
Keywords: macroalgae diversity, west coastal, Pananjung beach.
Parameter Estimation and Hypothesis Testing of Geographically and Temporally Weighted Bivariate Negative Binomial Regression
Authors: Ningrum Christin , . Purhadi , . Sutikno
Published: March 2024

When the response variable is discrete as a number (count) and there is a violation of the assumption of equidispersion, namely overdispersion or underdispersion then one of the appropriate alternative models used is Negative Binomial Regression (NBR). Moreover, if there are two correlated response variables and have an equidispersion violation, the Bivariate Negative Binomial Regression (BNBR) model is the solution. However, the BNBR model is considered inappropriate if the data contains spatial and temporal heterogeneity derived from panel data with the unit of observation in the form of a region. Therefore, a model is offered which is known as Geographically and Temporally Weighted Bivariate Negative Binomial Regression (GTWBNBR) which accommodates spatial and temporal effects. This study aims to conduct parameter estimates and test statistics for the GTWBNBR model. Estimated parameters use Maximum Likelihood Estimation (MLE) with BHHH numerical iteration because the MLE estimates are not closed-form. When the sample size is large, the Maximum Likelihood Ratio Test (MLRT) is used for simultaneous parameter testing while the test statistic for partial parameter testing approaches the Chi-Square distribution so that it can be tested using the Z-Test.
Keywords: parameter estimation, hypothesis testing, GTWBNBR
Parameter Estimation and Hypothesis Testing of Geographically and Temporally Weighted Bivariate Weibull Regression
Authors: Prasetya Muhammad Eka , . Purhadi , . Sutikno
Published: March 2024

In global regression, there is an assumption in the form of an error from a normally distributed model, so data that is normally distributed is required. But in reality, not all of the tested data meet the normal distribution. One of the theoretical distributions of continuous random variables that is often used is the Weibull distribution, where the Weibull distribution is a distribution that is often used to analyze the reliability of an object. If there are two response variables that are correlated with each other, the appropriate method used is Bivariate Weibull Regression (BWR). Spatial data has been widely used in various research fields. The Geographically Weighted Bivariate Weibull Regression (GWBWR) model is a model in which there are spatial effects, where there is spatial heterogeneity in bivariate regression with the response variable being Weibull distribution. In addition, panel data has also been applied in various cases, where panel data can provide information covering more than one time period. This can lead to a temporal effect. This study develops a model that can handle cases of spatial and temporal heterogeneity simultaneously, namely the Geographically and Temporally Weighted Bivariate Weibull Regression (GTWBWR) model. The parameter estimation in the model uses the Maximum Likelihood Estimation (MLE) method which gives results that are not closed-form, so it is continued with the Berndt-Hall-Hall-Hausman (BHHH) numerical iteration.
Keywords: parameter estimation, hypothesis testing, GWBWR
Effect of Moon Phase on Physical Parameters at the Mouth of the River
Authors: Setya Winda , Paujiah Epa , Amalia Yusri , Burhaanuddin Subagja
Published: March 2024

Light from the sun is the need for living things both on land and in the air. The moon, as a medium that reflects sunlight in one month, has several phases. This phase affects the situation on earth, especially river mouths. This study aims to determine the effect of the moon phase on physical parameters (water temperature and air temperature) at the mouth of the river. This research was conducted in 4 moon phases on the physics parameters at three coastal estuaries during the day and night. Based on the study results, it was found that the moon phase of the physical parameters is very influential on the number of micro-organisms. The number of organisms in each estuary also shows different characteristics according to moon phase conditions.
Keywords: moon phase, physical parameter
Effect of Internet Addiction on Academic Achievement and Musculoskeletal Disorders of University Students
Authors: Bahrami Mahsa , Ghelichi Farideh , Rahimizadeh Vahid , Talebi Seyedeh Solmaz , Mousavi Shakib Akram Sadat , Biganeh Jamal
Published: March 2024

Introduction: Today, various platforms, including virtual networks and websites, connect people with a lot of data via Internet. The attractiveness of these platforms sometimes makes people use them addictively. Uncontrolled use of the Internet may also cause problems such as reducing academic performance and creating musculoskeletal problems.
Methods: This cross-sectional study was conducted on 400 students at one of the universities of medical sciences. Four demographic questionnaires, Young's Internet addiction, Pham and Taylor's academic achievement and Nordic questionnaire were used to collect information. Data analysis was done using descriptive tests and Pearson's correlation, by SPSS V.16 software at a significance level of 0.05.
Results: The highest prevalence of musculoskeletal disorders was related to the upper back (40.8%), lower back (36%) and neck (33.8%) regions. Among different parts of the body, reports of pain in the neck, shoulder, and wrist had a significant relationship with Internet addiction (P-Value: 0.038, 0.007, and 0.029, respectively). No significant relationship was found between different levels of Internet addiction and academic achievement.
Conclusion: The prevalence of musculoskeletal disorders is one of the complications of incorrect and unprincipled use of Internet-related equipment; Therefore, these problems can be reduced by providing appropriate educational platforms and creating a correct culture of using emerging technologies
Investigating the important proteins in causing West Nile virus infection in retinal pigment cells
Authors: Hosseinzadeh Reza , Mohammadi Mahnaz , Taheri Saba
Published: March 2024

Introduction: West Nile virus is an infection transmitted through blood-sucking arthropods. Ocular manifestations are one of the characteristics of West Nile virus infection. They occur mostly in connection with severe neurological disease. In this study، using bioinformatics analysis، we investigated and identified the genes in the pathways related to West Nile virus infection in the retina.
Methods: In this study, using bioinformatics methods and referring to the GEO dataset, the appropriate dataset was selected for analysis. This dataset included gene expression profiles in West Nile virus infection with retinal pigment cells. Gene clusters with high and low expression were categorized. For more accurate data evaluation,  databases such as Enrichr، STRING and Network analyst were used. The candidate genes were isolated and their protein relationship was also measured using cytoescape software version 3.7.1. The obtained values with P-Value˂0.05 were selected as significant data.
Results: The number of 830 genes with high expression and 500 genes with low expression was involved in the development pathways of West Nile virus infection in the eye. Apoptosis، necroptosis، AMPK and MAPK autophagy pathways were clearly observed. After evaluating the relationship between protein networks، RIPK1، STAT1/3 and JAK2 increased expression and GSK3B، MAPK8 and TSC2 genes had decreased expression.
Conclusion: The present study showed that important proteins and genes played a major role in strengthening West Nile virus inflammation in the retina, among which RIPK1,TSC2, STAT1 and JAK2 showed a more prominent role in this pathway.
Peculiarities of biochemical and mineral composition of lettuce Lactuca sativa L. grown from seeds after long-term storage in the International Space Station
Authors: Kharchenko V. A. , Golubkina N. А. , Skrypnik L. N. , Murariu O. C. , Caruso G.
Published: March 2024

Seed storage of agricultural crops in the conditions of International Space Station (ISS) is an effective method of quick plant breeding aimed to enhance the adaptability, and improve the biologically active compound accumulation and crop yield. Biochemical and mineral composition (ICP-MS) of lettuce grown in greenhouse from seeds stored for one year at the ISS was assessed. High varietal differences in lettuce tolerance to the effect of micro-gravity and radiation were evaluated using the values of yield, biometrical parameters, antioxidant status and plant mineral composition. Among the cultivars studied, i.e. Petrovich, Synthesis, Moskovsky parnikovy, Picnic, Cavalier and Bouquet, only the cvs. Retrovich, Synthesis, Moskovsky parnikovy and Picnik retained seed viability. Significant yield increase was recorded for the cv. Moskovsky parnikovy, while the cvs. Petrovich, Synthesis and Picnic demonstrated a tendency to the yield decrease. Improvement of photosynthetic pigment accumulation due to seed space storage was recorded for the cv. Moskovsky parnikovy and, particularly, the latter cultivar differed from the other cvs. due to the significantly higher proline level and lower MDA levels in leaves. Though space stress did not cause any significant decrease in antioxidant accumulation of plants, the latter demonstrated valuable changes in mineral composition. Among the 23 elements tested, V, Se. Fe and Cr showed higher concentrations compared to those in the control plants. Positive correlations between Ca, Sr, Cd, Cp, Mg, Mo and Pb were recorded (r > 0.9; p < 0.001).
Exchange Rates and Capital Market Instruments – Analysis Based on the Example of Switzerland before and during the Covid-19 Pandemic
Authors: Bolek Cezary , Bolek Monika
Published: March 2024

The purpose of the article. The aim of the article is to present factors influencing foreign exchange rates and to examine the relationship between them and stock and bond indices in Switzerland in the period before and during the COVID-19 pandemic. The hypothesis that the studied relationships changed as a result of the turmoil caused by the pandemic crisis was verified.
Methodology. To verify the hypothesis, linear and non-linear functions were analyzed, and Pearson's correlation indices between the examined instruments were calculated.
Results of the research. As a result of the analysis, it was found that the relationship between the CHF exchange rate index and stock indices is non-linear, and the relationship between the CHF exchange rate index and bond indices is linear. Correlation coefficients before the pandemic indicated strong relationships between the CHF exchange rate index and the examined capital market indices, and moreover, the relationship with stock indices was positive and with bond indices negative. It was found that during the pandemic, the correlation with bond indices changed and became positive. The motivation of the analysis is related to the spotlight on a Swiss franc as a result of numerous financial decisions related to this currency.
Indirect Taxation: Assessing the Impact of the Sugar Tax in Poland
Authors: Rosiński Rafał , Mundziel Julia
Published: March 2024

The purpose of the article. In 2019, Poland introduced a sugar tax that encompassed food products, including beverages. Since the sugar tax is a form of indirect taxation, consumers bear its burden in the price of the purchased product. In response, businesses often adjust prices or reduce product quantities to offset their costs. This article aims to characterize the fiscal and non-fiscal significance of the sugar tax and to illustrate its impact on the financial situation of a selected soft drink industry enterprise.

Methodology. The applied research methods include a literature review analysis, analysis of legal acts and financial data analysis.

Results of the research. The impact of the sugar tax on a company can be diverse and dependent on various factors. Its fiscal and non-fiscal nature means that, on the one hand, the goal is to reduce the consumption of "harmful products" to improve public health by reducing sugar intake and addressing health problems related to excessive consumption of sugary beverages. On the other hand, it aims to generate additional revenue for the state budget. It also has implications for the financial situation of the company.The results of the analysis indicate that the sugar tax, due to its pass-through nature, remains neutral for businesses, without adversely affecting revenue, profitability or financial liquidity.
Ultrasonographic Evaluation of Gastro-intestinal Dysfunction in Rescued Olive Ridley Sea Turtles (Lepidochelys olivacea)
Authors: Ramakrishnan A. , Palanivelrajan M. , Sumathi D. , Prathaban S. , Senthilkumar K.
Published: March 2024

Background: The olive ridley sea turtle is a common inhabitant of primarily in the Pacific and Indian Oceans. Sea turtles show poor clinical signs and due to the existence of carapace and plastron, physical examination requires complementary diagnostic methodology to provide valuable information for clinical diagnosis. Methods: This work describes the normal ultrasonographic appearance of cervical structures and gastro-intestinal organs of seven olive ridley sea turtles that were stranded during September 2017 to April 2018 along with rescued sea turtle by Trust for Environmental and Education (TREE) foundation, Vettuvankeni, Chennai, Tamil Nadu. Ultrasound examination was performed with multi frequency Probe (3.5 MHz to 7.5 MHz) transducer. Ten soft-tissue areas of integument were used as acoustic windows. Result: On ultrasonographic examination of the cervical-ventral acoustic window, the esophagus was imaged. The stomach was more frequently seen through the left axillary acoustic window. The liver could be imaged through both sides of the axillary window and the right axillary acoustic window was the most indicated to visualize the gallbladder. The large and small intestines could be seen in the prefemoral and post femoral acoustic window on the both the sides. The ultrasonographic measurement of various organs was done furthermore gastrointestinal dysfunctions were recorded. This study on ultrasound indices was found to be a useful diagnostic tool for evaluation of coelomic organs in olive ridley.
Horacio Acosta y Lara, “leader” de la causa profesional en Uruguay en la primera mitad del siglo XX
Authors: Medero Santiago
Published: March 2024

En este artículo se analiza al arquitecto Horacio Acosta y Lara (Montevideo, 1875-1966) en tanto figura relevante de la profesión: primer presidente de la Sociedad de Arquitectos, primer decano de la Facultad de Arquitectura, primer presidente de los Congresos Panamericanos de Arquitectos y personalidad de proyección internacional. Pero el interés no consiste en resumir su biografía sino en examinar su función al interior de la organización profesional. Se sostiene aquí que su figura se construyó, por parte de sus colegas y de él mismo, como la de un héroe profesional. El objetivo del artículo es brindar pautas para comprender el reconocimiento obtenido por Acosta y Lara y, más importante aún, para entender cómo construyó ese reconocimiento y qué vínculos tenía con aquello que la profesión deseaba. Se sostiene entonces que, más allá de sus méritos personales, la acumulación de capital simbólico estuvo ligada a las necesidades y la autopercepción de la profesión arquitectónica, que veía en su figura la encarnación de sus propios ideales, aun si la actuación de Acosta y Lara no estuvo exenta de contradicciones. El método que se ha elegido para este estudio parte de la revisión cualitativa de una serie de fuentes escritas seleccionadas. En particular, se hará énfasis en el número doble de la revista Arquitectura, publicación de la Sociedad de Arquitectos, de julio-agosto de 1929, que homenajea la figura de Acosta y Lara. Este documento, no solamente nos permite adentrarnos en su trayectoria, sino que evidencia las características del personaje que se exaltan (y aquellas que no), lo que nos permite vislumbrar los rasgos más nítidos del “ideal profesional” buscado por los arquitectos.
MALA ISTORIJA KVARENJA
Authors: PROLE DRAGAN
Published: March 2024

Nije neobično da u savremenosti često zatičemo pomen „greha“, udobno i bezazleno smeštenog među znakove navoda. Oni imaju ulogu da naglase da je prošla opasnost, jer na horizontu više nema Boga kao glavnog sudije koji kažnjava zbog greha. Za većinu sekularnih savremenika pojam greha više ništa ne znači, ostaje oznaka za jučerašnju pretnju uz čiju pomoć je institucija crkve nastojala da precizira i obeća sankciju za sve oblike ponašanja koje je smatrala kažnjivim i neprihvatljivim. U najboljem slučaju, sekularna svest pristaje da smrtnim grehovima prizna status poroka, jer nakon „smrti Boga“ zajednica ponovo ostaje da važi kao jedini moralni sudija. Članak ispituje istoriju pojmova poroka, zapovesti i greha, nastojeći da pokaže njihovo mesto u savremenosti.
THE COMMUNIST TERRITORIALITY: MARX, DELEUZE, GUATTARI, AND TWENTIETH CENTURY SOCIALISM
Authors: MARIA GNERRE ORAZIO
Published: March 2024

This article presents the question of the relationship between politics and territoriality in the philosophical-social perspective of Marx and the followers of his ideas in the last century. In this sense, the classical Marxist thought is placed in opposition with that of Deleuze and Guattari with regard to the importance, in the dialectic between territoriality and deterritorialization, of the former with respect to the latter. The thought of Marx and the more or less faithful attempts to apply it in the previous century has always had at its center the relationship between human groups and the territory, which in symbolic terms according to Deleuze and Guattari represents the stability of existence. In this sense, Marx and his interpreters favored the last triadic moment in the process of the development of the relationship between people and territory: that of communist re-territorialization.
PYR – PERZISTENTNI SUPSTRAT SVEGA
Authors: KALUĐEROVIĆ ŽELJKO
Published: March 2024

Autor u radu analizira Stagiraninovo viđenje Efežaninove filozofije, koja je posmatrana uglavnom kroz prizmu njegove četvorovrsne kauzalne shematike. Aristotel je snažno argumentovao i dosledno branio vlastitu tezu da je Heraklit bio tipični predstavnik jonske filozofije prirode. Ovakav svoj stav on nije zastupao na osnovu mesta rođenja ili porekla „mračnogˮ mislioca, nego ga je fundirao imajući primarno u vidu Efežaninovo postuliranje osnovnog bivstva. Osnivač Likeja je, nakon temeljitog proučavanja Heraklitovih fragmenata, utvrdio da je pyr perzistentni supstrat svega i da ona treba da bude tretirana kao arche i physis u karakterističnom jonskom smislu. Kod Heraklita je, konačno, bilo reči o jednom načelu, vatri, koje je „tvarnog oblika” i koje je u Aristotelovoj tipologiji uzroka bilo svrstano u kategoriju materijalnog uzroka.
A Model for Describing the Management Processes in the Scientific Sector. Verification
Authors: Shepelev Gennady
Published: March 2024

The model of management in the scientific sector presented in the previous article, as well as some alternative models applied to the organization of science management are used to interpret various statistical data. The article also considers intersectoral comparisons of science financing in countries of different levels of economic development, including the costs of basic research. It is shown that the correlation between science costs and gross domestic product (GDP) is 32.9% in more than 120 countries of the world and GDP per capita is 50.9%. They are not statistically significant. On average, the share of basic study costs in domestic research and development expenses does not depend on the level of wealth of countries. This allows us to conclude in favor of a mutually consistent management model in the scientific sector. The author analyzes the dynamics of the number of researchers and small enterprises in the sector of science and scientific services, as well as the dynamics of the number of academic employees in the sectors of science in the 1990s. It is demonstrated that the decrease in their number mainly occurred in the applied sectors and to a lesser extent in the fundamental research sector. These data are described more fully by the proposed mutually consistent model of science than by the alternative models. Possible adjustments in the organization of the scientific sector management system are examined, including in terms of changes in input impacts on the science sector, output indicators characterizing its effectiveness, as well as changes in the organization of the scientific sector and management bodies, which follow from the considered mutually agreed management model in this sector of the economy.
In memory of B.M. Firsov (1929—2024). A Little Known Side of B.M. Firsov
Authors: Doktorov Boris
Published: March 2024

On the 18th of January we lost Boris Maksimovich Firsov (1929–2024), a scientist of exceptional magnitude and a person of extraordinary civic courage. He most certainly can be regarded as a man of different eras with rich and diverse life experience. Early on in his career he held high-ranking management positions, and he would later go on to conduct complex scientific and organizational operations in the field of sociology. His research covered various strata, states of mass consciousness, the history of sociology, and in more recent years — social history. Boris Firsov is responsible for establishing the Sociology institute of the RAS, he was the founder and first rector of the European University at St. Petersburg. He was frequently mentioned by his colleagues in their writing, and in the year 2021 a book by V. Vyzhutovich titled “Boris Firsov” came out as part of the “Life of remarkable people. Biography continues” book series. The author of this article had been a friend and colleague of Firsov for half a century, and as such is in a position to detail certain aspects about the life of Mr. Firsov and his scientific research that are not well known to the public. The article goes into B. Firsov’s involvement in the world of theater: his significant contribution to putting together a play called “Springtime at the LETI” [Leningrad Electro-Technical Institute] (1953) which was an early symbol of the political thaw; the script he wrote for a play called “The Death of Vazir-Mukhtar” (1969) that never got to be shown on television and was based on a novel by Yuri Tynyanov; him participating in a one-of-a-kind project known as “Sociology and theater” (1973–1989).
Kinerja BUMDes dalam Pengembangan Ekonomi Masyarakat Desa Balung Kulon Kecamatan Balung Kabupaten Jember
Authors: Sholeha Wardatus , Rohman Hermanto , Sutomo Sutomo
Published: March 2024

Penelitian ini bertujuan untuk mendeskripsikan kinerja BUMDes dalam Pengembangan ekonomi masyarakat desa Balung Kulon Kecamatan Balung Kabupaten Jember. BUMDes balung Kulon memiliki 2 unit usaha, kerajinan dan pengelolaan sampah. Pada tahun 2021 BUMDes Balung Kulon meraih 6 nominasi BUMDes terbaik di Jawa Timur. BUMDes Balung Kulon dijadikan model percontohan di Kabupaten Jember. Faktaya BUMDes Balung Kulon belum mampu mengajak masyarakat dalam menabung sampahnya di bank sampah. Dari 4.245 jumlah keluarga hanya 110 keluarga yang bergabung di bank sampah BUMDes. Metode penelitian ini menggunakan pendekatan kuantitatif posivistik. Teknik pengumpulan data yang dilakukan yaitu data primer dan data sekunder. Teknik analisis data menggunakan pendekatan balanced scorecard dengan 8 indikator yang digunakan yaitu, retrun on assets, retrun on equity, net provit margin, retensi pelanggan, akuisi pelanggan, network growth ratio, pelatihan masyarakat, dan produktivitas pegawai. Hasil penelitian bahwa kinerja BUMDes dalam pendekatan Balanced Scorecard nilai akhir total BUMDes Balung Kulon sebesar 92,5% dengan kondisi sangat sehat kategotri AA.