bluuebunny/crossref_metadata_2025 huggingface dataset:
The roller chain lubricated with ferrofluids
Authors: Zhang Yanjuan , Yang Zhengqing , Li Decai
Published: October 2018

The sleeve of roller chain periodically squeezes the pin during the process of chain transmission. The lubrication oil located in the gap of the sleeve and pin will be pushed out and cannot be restored automatically. The absence of sufficient lubricating oil can cause friction, wear, and even the roller chain failure between the pin and the sleeve. This article presents a novel method and a new type of chain structure to lubricant roller chain with ferrofluids, which is capable of prolonging the service life of roller chain. The results show that ferrofluids can be remained in the clearance between the sleeve and the pin shaft under the effect of external magnetic field. The ferrofluids that were squeezed out of the clearance can be restored automatically, which ensure the reliability of chain transmission. And the external magnetic field effectively prevents the chain lubrication leakage due to the edge effect of the magnetic field.
Role of perceived social support in depressive and somatic symptoms experienced by Bedouin Arab and Jewish Israeli undergraduates
Authors: Abu-Kaf Sarah , Shahar Golan , Noyman-Veksler Gal , Priel Beatriz
Published: October 2018

Elevated levels of depressive and somatic symptoms have been documented among college students. Over the past two decades, there has been an increase in the number of Bedouin Arab students studying at institutions of higher education in southern Israel. To date, research on coping and mental health problems among students who are members of this ethnic minority has been limited. This study examined the role of three aspects of perceived social support – availability, satisfaction, and the ability to get emotional support – in predicting depressive and somatic symptoms among Jewish Israeli and Bedouin Arab college students. A total of 89 Bedouin and 101 Jewish first-year students participated in this study, which involved two assessment waves 12 to 14 months apart. Participants completed questionnaires assessing depressive symptoms, somatic complaints, three aspects of perceived social support, and demographics. At Time 1, Bedouin students exhibited higher levels of depressive and somatic symptoms and lower levels of all three aspects of social support. Regression analyses showed that level of emotional support was a prospective predictor of somatization at Time 2. Moreover, when levels of emotional support were low, ethnic group predicted depression at Time 2; emotional support predicted depression only among Bedouin Arabs. The present study highlights the importance of the use of emotional support in predicting somatic complaints and depressive symptoms specifically among Bedouin Arab students. Clinical implications on intervention programs for ethnic minority students will be discussed.
A dialectical reflection on the emergence of the ‘citizen as consumer’ as neoliberal citizenship: The 2013 Brazilian protests
Authors: Fontenelle Isleide A. , Pozzebon Marlei
Published: October 2018

In this article, we argue that citizenship conceived within a context of neoliberal rationality helps explain the emergence of what we term the ‘citizen as consumer’. We define the citizen as consumer as someone who relates to the state and the public realms from the private perspective of consumption. We ask how this emergent neoliberal citizen is configured in peripheral countries that are regarded as exemplifying ‘weak’ citizenship. To respond to this question, we consider the protests that occurred in Brazil in 2013 as an empirical illustration. Our main objective is to rethink the citizen/state relationship in consumer studies, employing a dialectical analysis to understand how the better-known consumer-citizen movement, in which the consumer acts as a citizen and gives birth, under a neoliberal rationality, to a movement that somehow disrupts these roles such that the citizen starts to act as a consumer. The Brazilian protests provide insights that advance debate on the scope and limits of the hybridisation between citizens and consumers and on the transformations in the relationship between citizenship and politics.
Combining historical data and bookmakers’ odds in modelling football scores
Authors: Egidi Leonardo , Pauli Francesco , Torelli Nicola
Published: October 2018

Modelling football outcomes has gained increasing attention, in large part due to the potential for making substantial profits. Despite the strong connection existing between football models and the bookmakers’ betting odds, no authors have used the latter for improving the fit and the predictive accuracy of these models. We have developed a hierarchical Bayesian Poisson model in which the scoring rates of the teams are convex combinations of parameters estimated from historical data and the additional source of the betting odds. We apply our analysis to a nine-year dataset of the most popular European leagues in order to predict match outcomes for their tenth seasons. In this article, we provide numerical and graphical checks for our model.
Predicting matches in international football tournaments with random forests
Authors: Schauberger Gunther , Groll Andreas
Published: October 2018

Many approaches that analyse and predict results of international matches in football are based on statistical models incorporating several potentially influential covariates with respect to a national team's success, such as the bookmakers’ ratings or the FIFA ranking. Based on all matches from the four previous FIFA World Cups 2002–2014, we compare the most common regression models that are based on the teams’ covariate information with regard to their predictive performances with an alternative modelling class, the so-called random forests. Random forests can be seen as a mixture between machine learning and statistical modelling and are known for their high predictive power. Here, we consider two different types of random forests depending on the choice of response. One type of random forests predicts the precise numbers of goals, while the other type considers the three match outcomes—win, draw and loss—using special algorithms for ordinal responses. To account for the specific data structure of football matches, in particular at FIFA World Cups, the random forest methods are slightly altered compared to their standard versions and adapted to the specific needs of the application to FIFA World Cup data.
DataSite: Proactive visual data exploration with computation of insight-based recommendations
Authors: Cui Zhe , Badam Sriram Karthik , Yalçin M Adil , Elmqvist Niklas
Published: October 2018

Effective data analysis ideally requires the analyst to have high expertise as well as high knowledge of the data. Even with such familiarity, manually pursuing all potential hypotheses and exploring all possible views is impractical. We present DataSite, a proactive visual analytics system where the burden of selecting and executing appropriate computations is shared by an automatic server-side computation engine. Salient features identified by these automatic background processes are surfaced as notifications in a feed timeline. DataSite effectively turns data analysis into a conversation between analyst and computer, thereby reducing the cognitive load and domain knowledge requirements. We validate the system with a user study comparing it to a recent visualization recommendation system, yielding significant improvement, particularly for complex analyses that existing analytics systems do not support well.
Aristotle’s realist regime theory
Authors: Szűcs Zoltán Gábor
Published: October 2018

The ambition of this article is threefold. First, it is to offer a realist reading of Aristotle’s regime theory as it is laid out mostly in Books IV–VI of his Politics. The author argues that Aristotle’s regime theory has three fundamentally realist claims about the workings of politics: first, the search for a perfect regime is not the only legitimate subject of political theory; second, every regime is built on a delicate balance of a particular understanding of political justice, a variety of sociological factors and the institutional design and political virtues of its politicians; third, there are almost as many different regimes as polities, and although they can be grouped into major regime types, there are many sub-types and mixed and transitory regimes. Second, the article argues that modern democratic theories have an unacceptable ‘moralistic bias’ from a realist point of view. Third, that a neo-Aristotelian regime theory can offer an attractive realist alternative to the predominant contemporary understandings of political regimes.
Reflective practice and student satisfaction: never the twain shall meet?
Authors: Pirrie Anne , Day Stephen
Published: October 2018

The focus of this article is the inter-relationship between two canonical notions in contemporary education discourse: ‘reflective practice’ and ‘student satisfaction’ in the context of the marketisation of higher education across Europe and the concomitant emphasis on student autonomy and institutional competitiveness. Drawing on the work of Jan Masschelein and Tim Ingold, the authors offer a critique of contemporary attempts to reanimate the notion of reflective practice. Drawing upon the work of Sharon Todd, the authors explore the theoretical underpinnings of contemporary approaches to reflective practice and suggest that these betoken an implicit commitment to a vision of education as a process of transmission rather than of educating the gaze. They trace the aetiology of the former back to the direction of education policy in the decades since the adoption of the Lisbon Strategy. They conclude that a nuanced approach to reflective practice entails a consideration of student satisfaction and fundamental shift in emphasis from epistemological or methodological towards existential concerns.
Using Video Feedback at Home in Dementia Care: A Feasibility Study
Authors: Gerritsen Debby L. , Koopmans Raymond T. C. M. , Walravens Veerle , van Vliet Deliane
Published: October 2018

Video feedback at home (VFH) aims to improve the well-being of informal caregivers and persons with dementia by training the caregiver to communicate successfully. This feasibility study had 2 aims: (1) to investigate possible effects regarding VFH, caregiver self-efficacy and the burden experienced, and the frequency of challenging behavior in persons with dementia, and (2) to perform a process evaluation of barriers and facilitators regarding the use of VFH. The respondents were caregivers of home-dwelling persons with dementia participating in VHF (N = 10), a group of caregivers who declined participating in VFH (N = 18), stakeholders (N = 6), and field experts (N = 55). The assessments performed were Positive and Negative Affect Scales, Cohen-Mansfield Agitation Inventory, Sense of Competence Scale, semistructured interviews, and questionnaires. Results demonstrated that caregivers were satisfied with VFH and that various (sub)scores on questionnaires improved. Caregivers mentioned a reluctance toward being filmed and both caregivers and referrers were unfamiliar with VFH. Recommendations have been made for health-care professionals and researchers to overcome these barriers.
Addressing Unmet Information Needs: Results of a Clinician-Led Consultation Service About Complementary and Alternative Medicine for Cancer Patients and Their Relatives
Authors: Horneber Markus , van Ackeren Gerd , Fischer Felix , Kappauf Herbert , Birkmann Josef
Published: October 2018

Purpose. To report on a telephone consultation service with cancer patients and their relatives about complementary and alternative medicine (CAM) between 1999 and 2011. Methods. We offered a Germany-wide, free-of-charge telephone consultation service about CAM led by oncology clinicians from a comprehensive cancer center. The consultations followed a patient-centered approach with the aim to provide guidance and evidence-based information. Sociodemographic, disease-related data as well as information about the consultations’ content were collected in a standardized manner, and feedback questionnaires were sent out immediately after the consultations. Results. Overall, 5269 callers from all over Germany used the service (57% patients, 43% relatives). The “big 4” cancer types (breast, gastrointestinal, prostate, and lung) accounted for 55% of all calls. In 67% of calls, patients had just received the diagnosis or commenced anticancer therapy; 69% of patients had advanced or metastatic diseases. More than half of the callers (55%) had vague concerns like “what else can I do?” rather than specific questions related to CAM. The consultations covered a broad spectrum of issues from CAM therapies to cancer treatment and measures supportive of health, nutrition, and psychosocial support. Callers highly valued the service. Conclusions. Consulting about CAM addresses important unmet needs from cancer patients and their relatives. It provides clinicians with the opportunity to engage in open and supportive dialogues about evidence-based CAM to help with symptom management, psychological support, and individual self-care. Consulting about CAM cannot be separated from consulting about conventional care and should be provided from the beginning of the cancer journey.
A Scoping Review of Qualitative Research Methods Used With People in Prison
Authors: Abbott Penelope , DiGiacomo Michelle , Magin Parker , Hu Wendy
Published: October 2018

Researchers undertaking qualitative interview and focus group research with people in prison must consider the research methods they use, given the ethical and practical complexities of prison-based research. In particular, there are explicit and implicit coercion risks and barriers to access, privacy, and confidentiality. To examine how the challenges of conducting rigorous qualitative research with prisoners were handled, we undertook a scoping review of recruitment and data collection processes reported in qualitative research with prisoners. We searched for peer-reviewed articles of qualitative interview and focus group research with adult prisoners, published in the English language from 2005 to 2017, using MEDLINE, Embase, PsycINFO, and CINAHL databases. There were 142 articles reporting on 126 studies which met the review inclusion criteria. Challenges related to coercion risk, participant recruitment, sampling, confidentiality, privacy, and working with prison-based intermediaries should be explicitly addressed and reported. Our findings highlight key considerations and contextualized strategies for recruitment and data collection for researchers who seek to conduct rigorous and ethical qualitative research with prisoners.
What does ‘Culture’ Mean in French? A Theoretical Mapping and Fractal Analysis of the Sociology of Culture in France
Authors: Alexandre Olivier
Published: October 2018

This article charts the development of the sociology of culture in France. First, it examines the hypothesis of a French model, putting into perspective the correlation between cultural policies and dedicated sociological inquiries at the end of the 1950s. ‘Culture’ is one of the oldest fields of research in France, and current research still derives from the same anthropological matrix. Yet French sociologists present themselves as part of a divided and competitive academic domain. This article, based on an encompassing review of the literature as well as on in-depth interviews, accordingly distinguishes eight different ‘schools’ – organized around pre-eminent academics, concept producers and resource providers – as well as circles of collaboration. Whilst these circles organize their theoretical activity around emblems (with the word ‘culture’ referring to different conceptual sets) the social relations in their midst are organized around dyads, which usually transition from positive collaboration to rivalry. The article highlights the importance of these divisions as a fractal process and as boundary work for scientific production. From this perspective, the sociology of culture in France could be described as a large and extensive system of concepts and collaborations developed within small groups, within and between which, as with all ‘cultural’ matters, symbolic activity is the key basis for social status.
Graininess of RGB-Display Space
Authors: Koenderink Jan , van Doorn Andrea , Gegenfurtner Karl
Published: October 2018

RGB–display space, that is, the ‘RGB–cube’, was sampled at 3,000 locations, uniformly and randomly distributed. Fifty observers contributed 60 samples each. At each location, participants synthesised a copy of the target, using a generic colour picker. The statistical distributions of errors as a function of location are used to define an overall measure of graininess. A smooth field of interpolated three-dimensional covariance ellipsoids represents an explicit, empirical Riemannian metric. The unit step size is about 20 times larger than the size of the classical MacAdam ellipses. We speculate that this metric might be found useful in various settings involving applications, because it reflects typical fuzziness encountered in generic tasks involving colour patterns such as images. Some of the more obvious applications are discussed.
Beyond weight loss: A qualitative exploration of participant expectations and strategies for measuring progress during a weight management program
Authors: Ingels John Spencer , Hansell Adam , Zizzi Sam
Published: October 2018

Objectives:

Previous research with participants in weight management has primarily focused on participant weight-loss expectations. The purpose of this study was to explore participant expectations and strategies for measuring progress during a community-based weight management program.

Methods:

Semi-structured interviews were completed with 22 participants with overweight or obesity, who were currently enrolled in a 2-year weight management program in order to understand their expectations and strategies for measuring their progress.

Results:

Aside from weight loss, participants’ expectations included improved health, fitness, and mood, gaining support, and developing new habits. Participants discussed measuring their success by focusing on weight loss and changes to their body, improved health, mood, and fitness, creation of new habits, and gaining additional support.

Conclusion:

The results of this study suggest that participant’s in a weight management program expected benefits beyond just weight loss.
Testicular seminoma in the aged rat visualized by phase-contrast X-ray computed tomography
Authors: Thet-Thet-Lwin  , Yoneyama Akio , Imai Motoki , Maruyama Hiroko , Hyodo Kazuyuki , Takeda Tohoru
Published: October 2018

Spontaneously growing testicular seminoma in the aged rat was imaged by one of the most sensitive imaging modalities, namely, phase-contrast X-ray computed tomography (CT) with crystal X-ray interferometry. Phase-contrast X-ray CT clearly depicted the detailed inner structures of the tumor and provided 20× magnified images compared to light-microscopic images. Phase-contrast X-ray CT images are generated based on density variations in the object, whereas pathological images are based on differentiation of cellular structures, such as the cellular nuclei and cytoplasm. The mechanism of image generation differs between the two techniques: phase-contrast X-ray CT detects even minute differences in the density among pathological structures, depending, for example, on the number and sizes of the nuclei, variations of the cytoplasmic components, and presence/absence of fibrous septa, cystic changes, and hemorrhage. Thus, phase-contrast X-ray CT with a spatial resolution of 26 µm might allow prediction of the morphological characteristics of a tumor even before histopathological processing.
Framing the Paralympic Games: A Mixed-Methods Analysis of Spanish Media Coverage of the Beijing 2008 and London 2012 Paralympic Games
Authors: Solves Josep , Pappous Athanasios , Rius Inmaculada , Kohe Geoffery Zain
Published: October 2018

In recent years, there has been an increased emergence of studies focusing on the media coverage of the Paralympic Games. Until recently, studies have predominately used quantitative content analyses that, although providing useful interrogation of observational patterns, limit the understanding of and appreciation for the contexts that may have shaped the production of information. By focusing exclusively on the “what” and on the “how much,” it is difficult to reveal the “why” and to identify the underlying motives of any changes. This article recognizes the nuances of the editorial decision-making process by using a mixed-methods approach, employing quantitative and qualitative data drawn from a case study focusing on the Spanish media coverage of the 2008 and 2012 Paralympic Games. An initial content analysis of all news published in Spain’s 12 highest circulation newspapers during Beijing 2008 and London 2012 Paralympic Games was undertaken. Subsequently, 15 semistructured interviews were conducted with journalists that were also sent to these two iterations of the Paralympic Games by Spanish media. Drawing on conceptualisations of media framing, the results highlight that the numerical data alone shed insufficient light on the complexity of the news-making process. The semistructured interviews brought to light issues such as editorial management buoyed by commercial imperatives, and organisational interjection in journalists’ narratives and authorship, that also contoured coverage and content. In addition to further debate about the complexities of media coverage of Paralympic sport, the study underscores the utility of incorporating and combining qualitative methodologies within sport media and communication research.
Is the alignment guide technique in total hip arthroplasty sufficient for accurate cup positioning with a modified Watson Jones approach?
Authors: Yoshitani Junya , Nakamura Takuya , Maruhashi Yoshinobu , Hashimoto Noriyuki , Sasagawa Takeshi , Ueshima Kenichi , Funaki Kiyonobu
Published: October 2018

Purpose:

Cup setting with only an alignment guide has been reported to be inaccurate in the lateral decubitus position in total hip arthroplasty (THA). We assessed the accuracy of cup positioning using only the alignment guide technique via a modified Watson Jones approach in the lateral decubitus position.

Methods:

Two hundred hips of 189 patients underwent THA from October 2014 to September 2016 via a modified Watson Jones approach. In the final sample, 181 hips of 171 patients (35 males, 136 females) were included in this investigation. The alignment of the cup was evaluated by an anteroposterior radiograph of the pelvis 1 week after surgery. Measurements were divided into safe zone determined by Callanan and Lewinnek.

Results:

There were 168 (92.8%) acetabular cups that were placed within the safe zone for both inclination and anteversion based on the safe zones defined by Lewinnek, and 134 (74%) acetabular cups that were placed within the safe zone defined by Callanan. Multiple logistic analysis showed that the laterality and the addition of the confirmation method were indicators for malpositioning of combined inclination and anteversion.

Conclusion:

Our data suggested that even if special tools were not used in the lateral decubitus position, using only the alignment guide enabled cup positioning to be achieved with 92.8% accuracy in the Lewinnek safe zone and 74% accuracy in the Callanan safe zone. Multiple logistic analysis showed that the laterality and the addition of a confirmation alignment guide influenced the accuracy of cup positioning.
Biomechanical Comparison of 3 Syndesmosis Repair Techniques With Suture Button Implants
Authors: Parker Andrew S. , Beason David P. , Slowik Jonathan S. , Sabatini Jefferson B. , Waldrop Norman E.
Published: October 2018

Background:

Suture button fixation of syndesmotic injury is growing in popularity, as it has been shown to provide adequate stability in a more cost-effective manner than screw fixation while allowing more physiologic distal tibiofibular joint motion. However, the optimal repair technique and implant orientation have yet to be determined.

Purpose/Hypothesis:

The purpose of this study was to biomechanically compare 3 suture button construct configurations/orientations for syndesmosis fixation: single, parallel, and divergent. The authors hypothesized that all 3 methods would provide adequate stabilization but that the divergent technique would be the most stable.

Study Design:

Controlled laboratory study.

Methods:

The fixation strengths of 3 stabilization techniques with suture button devices were compared with 10 cadaveric legs each (N = 30). Ankle motion under cyclic loading was measured in multiple planes: first in the intact state, then following simulated syndesmosis injury, and then following fixation with 1 of 3 randomly assigned constructs—1 suture button, 2 suture buttons in parallel, and 2 divergent suture buttons. Finally, axial loading with external rotation was applied to failure.

Results:

All syndesmotic fixation methods provided stability to the torn state. There was no statistically significant difference among the 3 fixation techniques in biomechanical stability. Failure most commonly occurred through fibular fracture at supraphysiologic loads.

Conclusion:

Suture button implant fixation for syndesmotic injury appears to provide stability to the torn syndesmosis, and the configuration of the fixation does not appear to affect the strength or security of the stabilization.

Clinical Relevance:

This study provides further insight into the biomechanics and optimal configuration of suture button fixation of the torn syndesmosis. Based on these results, the addition of a second suture button may not significantly contribute to immediate postoperative stability.
Potential Consequences of Spectral and Binaural Loudness Summation for Bilateral Hearing Aid Fitting
Authors: van Beurden Maarten , Boymans Monique , van Geleuken Mirjam , Oetting Dirk , Kollmeier Birger , Dreschler Wouter A.
Published: October 2018

Aversiveness of loud sounds is a frequent complaint by hearing aid users, especially when fitted bilaterally. This study investigates whether loudness summation can be held responsible for this finding. Two aspects of loudness summation should be taken into account: spectral loudness summation for broadband signals and binaural loudness summation for signals that are presented binaurally. In this study, the effect of different symmetrical hearing losses was studied. Measurements were obtained with the widely used technique of Adaptive Categorical Loudness Scaling. For large bandwidths, spectral loudness summation for hearing-impaired listeners was found to be greater than that for normal-hearing listeners, both for monaurally and binaurally presented signals. For binaural loudness summation, the effect of hearing loss was not significant. In all cases, individual differences were substantial.
Gender, Socioeconomic Status, and Diet Behaviors within Brazilian Families
Authors: Donnelly Rachel , Marteleto Leticia J.
Published: October 2018

Existing literature documents the key role that parents play in transmitting diet behaviors to their children; however, less is known about differences by parent and child gender within families, especially with attention to household socioeconomic status (SES). We use nationally representative household data from Brazil and ask how parent-child associations of diet behavior differ by gender within lower- and higher-SES households. Results indicate that both maternal and paternal diet behaviors are associated with sons’ and daughters’ diet behaviors, but the strength of these associations differs depending on the gender of both the parent and the child. Moreover, gender differences in parent-child diet resemblance exist primarily in lower-, but not in higher-SES households. These findings are important for understanding health processes that occur within families and lead to disparities across generations, especially in a middle-income country undergoing sharp economic and nutritional changes.
Institutional Supports and Life Satisfaction: The Case of Cross-border Marriage Migrants in South Korea
Authors: Oh Hyunsu
Published: October 2018

The positive influence of institutional supports from social networks on psychological well-being of immigrants is extensively acknowledged in the literature. However, immigration experiences outside the Western societies are underexplored. Using data from the 2012 Korean National Survey for Multicultural Family, I examine how institutional supports for cross-border marriage migration shape life satisfaction among female marriage migrants in South Korea. Findings reveal that levels of life satisfaction among marriage migrants married via commercially arranged marriage agencies are lower than those of female marriage migrants using interpersonal networks from kinship and friends/colleagues. Religion-motivated marriage migrants show lower levels of life satisfaction. In addition, the impacts of institutional supports on life satisfaction are mediated by marriage duration and language proficiency, indicating higher levels of satisfaction are associated with shorter marriage duration and better language proficiency; however, the impacts vary by institutional supports.
Sweet Rewards: An Exercise to Demonstrate Process Theories of Motivation
Authors: Holbrook Robert L. , Chappell David
Published: October 2018

Motivation is a fundamental component in management and organizational behavior courses. At the same time, it can be a complicated topic for teaching and learning due to the number of popular models and theories. The activity described here is a simple and fast way to illustrate the components of two of the most important and practical motivation theories—Equity Theory and Expectancy Theory. The impact of the activity will be realized the moment a disproportional reward is made. We outline implementation steps and provide an extensive list of questions to check students’ understanding of motivation theories. We also provide additional resources (i.e., media suggestions, discussion slides) to enhance classroom presentations. This exercise is designed primarily for management and organizational behavior courses. It can be used effectively with a variety of audiences (i.e., undergraduate, graduate, executive).
Effects of openings on the wind–sound environment in the traditional residential streets in a severe cold city of China
Authors: Jin Yumeng , Jin Hong , Kang Jian , Yu Ziyue
Published: October 2018

The streets in the traditional residential areas of severe cold cities in China often have openings leading to enclosed courtyards. These openings connect the street to the courtyard space, which affects the physical environment of the residential streets. This paper uses field measurements and numerical simulation to study the wind–sound environment in the street, comparing and analysing the effects of the existence, size and form of openings on the wind–sound environment in the street. The results indicate that both the average wind velocity and sound pressure level have some degree of reduction around the opening, with the difference of wind velocity reaching 1.0 m/s and the difference in sound pressure level reaching 0.5–1.6 dB. Additionally, the T30 changes from 0.2 s to 0.4 s around the opening, while the average T30 in the street also varies. Increasing the width of the opening by 1 m increases the influential range of the opening on the sound environment by 0.5–4 m. In contrast, the width of the opening has little effect on the sound pressure level and the T30. Compared with an entrance of the same width, a gap intensifies the fluctuation of the local wind velocity and causes the average T30 to reduce by 0.3 s. The results of this paper lay a data foundation for further studies on the optimized design of the physical environment in enclosed residential areas.
Who Should Do Replication Labor?
Authors: Romero Felipe
Published: October 2018

Scientists, for the most part, want to get it right. However, the social structures that govern their work undermine that aim, and this leads to nonreplicable findings in many fields. Because the social structure of science is a decentralized system, it is difficult to intervene. In this article, I discuss how we might do so, focusing on self-corrective-labor schemes (i.e., ways of distributing replication efforts within the scientific community). First, I argue that we need to implement a scheme that makes replication work outcome independent, systematic, and sustainable. Second, I use these three criteria to evaluate extant proposals, which place the responsibility for replication on original researchers, consumers of their research, students, or many labs. Third, on the basis of a philosophical analysis of the reward system of science and the benefits of the division of cognitive labor, I propose a scheme that satisfies the criteria better: the professional scheme. This scheme has two main components. First, the scientific community is organized into two groups: discovery researchers, who produce new findings, and confirmation researchers, whose primary function is to do confirmation work (i.e., replication, reproduction, meta-analysis). Second, a distinct reward system is established for confirmation researchers so that their career advancement is separated from whether they obtain positive experimental results.
RETRACTED ARTICLE: Repertoire of the gut microbiota from stomach to colon using culturomics and next-generation sequencing
Authors: Mailhe Morgane , Ricaboni Davide , Vitton Véronique , Gonzalez Jean-Michel , Bachar Dipankar , Dubourg Grégory , Cadoret Frédéric , Robert Catherine , Delerce Jérémy , Levasseur Anthony , Fournier Pierre-Edouard , Angelakis Emmanouil , Lagier Jean-Christophe , Raoult Didier
Published: October 2018

Background

Most studies on the human microbiota have analyzed stool samples, although a large proportion of the absorption of nutrients takes place in upper gut tract. We collected samples from different locations along the entire gastrointestinal tract from six patients who had simultaneously undergone upper endoscopy and colonoscopy, to perform a comprehensive analysis using culturomics with matrix assisted laser desorption ionisation - time of flight (MALDI-TOF) identification and by metagenomics targeting the 16S ribosomal ribonucleic acid (rRNA) gene.

Results

Using culturomics, we isolated 368 different bacterial species, including 37 new species. Fewer species were isolated in the upper gut: 110 in the stomach and 106 in the duodenum, while 235 were isolated from the left colon (p < 0.02). We isolated fewer aero-intolerant species in the upper gut: 37 from the stomach and 150 from the left colon (p < 0.004). Using metagenomics, 1,021 species were identified. The upper gut microbiota was revealed to be less rich than the lower gut microbiota, with 37,622 reads from the stomach, 28,390 from the duodenum, and 79,047 from the left colon (p < 0.009). There were fewer reads for aero-intolerant species in the upper gut (8,656 in the stomach, 5,188 in the duodenum and 72,262 in the left colon, p < 0.02).

Patients taking proton pump inhibitors (PPI) were then revealed to have a higher stomach pH and a greater diversity of species in the upper digestive tract than patients not receiving treatment (p < 0.001).

Conclusion

Significant modifications in bacterial composition and diversity exist throughout the gastrointestinal tract. We suggest that the upper gut may be key to understanding the relationship between the gut microbiota and health.
Experimental and analytical investigation on resin impregnation behavior in continuous carbon fiber reinforced thermoplastic polyimide composites
Authors: Kazano Shota , Osada Toshiko , Kobayashi Satoshi , Goto Ken
Published: October 2018

In molding of carbon fiber reinforced thermoplastics (CFRTP), resin impregnation behavior to fiber yarns is very important because higher viscosity of molten thermoplastics inhibites resin impregnation to the interspace among fibers. Resultant resin un-impregnation causes lower mechanical properties of CFRTP. The purpose of this study was to clarify the relation among molding method, molding conditions and resin impregnation to fiber yarns experimentally and analytically. In this study, CFRTPs using continuous carbon fiber yarn as a reinforcement and a thermoplastic polyimide which is excellent in heat resistance as a matrix resin were produced by Micro-Braiding, Film Stacking and Powder method. In addition resin impregnation was modeled based on Darcy’s law and continuity condition. As a result, analytical resin impregnation prediction showed good agreements with the experimental results in all the producing methods and molding conditions. In addition, the void content in the molded CFRP could be greatly reduced by pressurizing cooling.
Colorectal Cancer in Ukraine: Regional Disparities and National Trends in Incidence, Management, and Mortality
Authors: Melnitchouk Nelya , Shabat Galyna , Lu Pamela , Lyu Heather , Scully Rebecca , Leung Krystle , Jarman Molly , Lukashenko Andrey , Kolesnik Olena O. , Goldberg Joel , Davids Jennifer S. , Bleday Ronald
Published: October 2018

Purpose

The incidence of colorectal cancer (CRC) is increasing worldwide, and the greatest increase is in low- to middle-income countries, such as Ukraine. Better knowledge of epidemiology of CRC in Ukraine is needed to understand how best to decrease the burden of disease.

Methods

The National Cancer Registry of Ukraine (NCRU) was queried for CRC incidence, mortality, stage, and treatment in Ukraine and assessed for regional variation from 1999 to 2015. Joinpoint analysis was used to analyze the trends.

Results

The incidence of colon cancer increased from 10.6 to 13.3 occurrences per 100,000, which provided an average annual percent change (AAPC) of 1.48 (95% CI, 1.3 to 1.7; P < .05). The incidence of rectal and anal cancers also increased from 9.9 to 11.5 occurrences per 100,000, which provided an AAPC of 1.0 (95% CI, 0.8 to 1.3; P < .05). Mortality remained the same (AAPC, 0.1; 95% CI, −0.3 to 0.2; P = .4). The proportion of patients who received cancer-specific treatment increased from 54.6% to 68.5% for colon cancer and from 61% to 74.4% for rectal and anal cancers. Overall, 34.5% of patients with colon cancer and 27.5% of patients with rectal cancer died within a year of diagnosis in 2015. Great regional variations in 1-year mortality and treatment received were identified.

Conclusion

The incidence of CRC in Ukraine is increasing. Despite stable mortality rates, many do not receive cancer-specific treatment, and a large proportion of patients die within a year of diagnosis. These findings illustrate the need to promote establishment of a screening program and to improve access to cancer-specific therapy in Ukraine.
N-linked glycosylation restricts the function of short gastrulation to bind and shuttle BMPs
Authors: Negreiros E. , Herszterg S. , Hwa K. , Câmara A. , Dias W. B. , Carneiro K. , Bier E. , Todeschini A. , Araujo H.
Published: October 2018

Disorders of N-linked glycosylation are increasingly reported in the literature. However, targets responsible for the associated developmental and physiological defects are largely unknown. Bone Morphogenetic Proteins (BMPs) act as highly dynamic complexes to regulate several functions during development. The range and strength of BMP activity depend on interactions with glycosylated protein complexes in the extracellular milieu. Here we investigate the role of glycosylation for the function of the conserved extracellular BMP antagonist Short gastrulation (Sog). We identify conserved N-glycosylated sites and describe the effect of mutating these residues on BMP pathway activity in Drosophila. Functional analysis reveals that loss of individual Sog glycosylation sites enhances BMP antagonism and/or increases the spatial range of Sog effects in the tissue. Mechanistically, we provide evidence that N-terminal and stem glycosylation controls extracellular Sog levels and distribution. The identification of similar residues in vertebrate Chordin proteins suggests that N-glycosylation may be an evolutionarily conserved process that adds complexity to the regulation of BMP activity.
Immune regulation of metastasis: mechanistic insights and therapeutic opportunities
Authors: Blomberg Olga S. , Spagnuolo Lorenzo , de Visser Karin E.
Published: October 2018

Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells tightly interact with the immune system and they influence each other, both in the tumor microenvironment and systemically. The crosstalk between cancer and immune cells adds another layer of complexity to our understanding of metastasis formation, but at the same time opens new therapeutic opportunities for cancer patients. The intensifying development of immunotherapeutic strategies calls for a better understanding of immune regulation of metastasis in order to maximize the therapeutic benefit for patients with metastatic disease. In this Review and accompanying poster, we describe the main mechanisms of immune regulation of metastasis that have been reported to date, and present promising immunotherapeutic options that are currently available, or may become so in the near future, to tackle metastasis.
Greatwall kinase at a glance
Authors: Castro Anna , Lorca Thierry
Published: October 2018

Mitosis is controlled by a subtle balance between kinase and phosphatase activities that involve the master mitotic kinase cyclin-B–Cdk1 and its antagonizing protein phosphatase 2A-B55 (PP2A-B55). Importantly, the Greatwall (Gwl; known as Mastl in mammals, Rim15 in budding yeast and Ppk18 in fission yeast) kinase pathway regulates PP2A-B55 activity by phosphorylating two proteins, cAMP-regulated phosphoprotein 19 (Arpp19) and α-endosulfine (ENSA). This phosphorylation turns these proteins into potent inhibitors of PP2A-B55, thereby promoting a correct timing and progression of mitosis. In this Cell Science at a Glance article and the accompanying poster, we discuss how Gwl is regulated in space and time, and how the Gwl–Arpp19–ENSA–PP2A-B55 pathway plays an essential role in the control of M and S phases from yeast to human. We also summarize how Gwl modulates oncogenic properties of cells and how nutrient deprivation influences Gwl activity.
Energy Expenditure during Extreme Endurance Exercise: The Giro d’Italia
Authors: PLASQUI GUY , RIETJENS GERARD , LAMBRIKS LARS , WOUTERS LOEK , SARIS WIM H. M.
Published: October 2018

Purpose

Little data are available on doubly labeled water (DLW) assessed total daily energy expenditure (TDEE) during extreme endurance exercise. Doubly labeled water is considered the gold standard to measure TDEE, but different calculations are being used, which may have a large impact on the results. The aim of the current study was to measure TDEE during the Giro d’Italia and apply two different calculation methods.

Methods

Seven male cyclists (age, 28 ± 5 yr; body mass index, 22.1 ± 2.1 kg·m−2) completed the 24-d professional cycling race “Giro d’Italia” in which a total distance of 3445 km was covered, including 10 mountain stages. Total daily energy expenditure was measured over the entire duration of the race, with the ingestion of DLW at three different time points. To calculate TDEE and body composition, the isotope dilution space was calculated using two different techniques, the “plateau” and “intercept” technique.

Results

The %fat mass at baseline was 7.8% and 16.8% with the plateau and intercept technique respectively and did not significantly change over the course of the race. Total daily energy expenditure was on average 32.3 ± 3.4 MJ·d−1 using the plateau technique versus 28.9 ± 3.2 using the intercept technique, resulting in an average physical activity level (PAL) of 4.37 ± 0.43 versus 3.91 ± 0.39, respectively. The dilution space ratio was on average 1.030 with the plateau and 1.060 with the intercept technique.

Conclusions

Given that the observed dilution space ratio with the plateau technique is similar as the expected ratio from literature and the % fat mass of 7.8% is more realistic for the athletes being studied, we propose the application of the plateau rather than the intercept method, when using DLW during extreme endurance exercise.
Chronic Adherence to a Ketogenic Diet Modifies Iron Metabolism in Elite Athletes
Authors: MCKAY ALANNAH K. A. , PEELING PETER , PYNE DAVID B. , WELVAERT MARIJKE , TEE NICOLIN , LECKEY JILL J. , SHARMA AVISH P. , ROSS MEGAN L. R. , GARVICAN-LEWIS LAURA A. , SWINKELS DORINE W. , LAARAKKERS COBY M. , BURKE LOUISE M.
Published: October 2018

Purpose

The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. This study examined the effect of a chronic ketogenic low-CHO high-fat (LCHF) diet on iron status and iron-regulatory markers in elite athletes.

Methods

International-level race walkers (n = 50) were allocated to one of three dietary interventions: (i) a high-CHO diet (n = 16), (ii) a periodized CHO availability (n = 17), or (iii) an LCHF diet (n = 17) while completing a periodized training program for 3 wk. A 19- to 25-km race walking test protocol was completed at baseline and after adaptation, and changes in serum ferritin, IL-6, and hepcidin concentrations were measured. Results from high-CHO and periodized CHO were combined into one group (CHO; n = 33) for analysis.

Results

The decrease in serum ferritin across the intervention period was substantially greater in the CHO group (37%) compared with the LCHF (23%) group (P = 0.021). After dietary intervention, the postexercise increase in IL-6 was greater in LCHF (13.6-fold increase; 95% confidence interval [CI] = 7.1–21.4) than athletes adhering to a CHO-rich diet (7.6-fold increase; 95% CI = 5.5–10.2; P = 0.033). Although no significant differences occurred between diets, CI values indicate that 3 h postexercise hepcidin concentrations were lower after dietary intervention compared with baseline in CHO (β = −4.3; 95% CI = −6.6 to −2.0), with no differences evident in LCHF.

Conclusion

Athletes who adhered to a CHO-rich diet experienced favorable changes to the postexercise IL-6 and hepcidin response, relative to the LCHF group. Lower serum ferritin after 3 wk of additional dietary CHO might reflect a larger more adaptive hematological response to training.