bluuebunny/crossref_metadata_2025 huggingface dataset:
Beyond Pelvic Incidence–Lumbar Lordosis Mismatch: The Importance of Assessing the Entire Spine to Achieve Global Sagittal Alignment
Authors: Merrill Robert K. , Kim Jun S. , Leven Dante M. , Kim Joung Heon , Cho Samuel K.
Published: April 2017

Study Design:

Retrospective case series.

Objective:

To investigate which sagittal parameters contribute to a normal sagittal vertical axis (SVA) when there is a pelvic incidence-lumbar lordosis (PI-LL) mismatch >10° following adult spinal deformity (ASD) correction.

Methods:

We performed a retrospective review of ASD patients with >5 levels fused. Sagittal measurements between cohorts of postoperative PI-LL >10° and PI-LL<10° were compared. We correlated SVA to pelvic tilt (PT), thoracic kyphosis (TK), PI-LL, cervical lordosis (CL), and correlated the pre- to postoperative change in SVA to change in PT, change in TK, change in PI-LL, and change in CL. We also correlated SVA and the change in SVA to combined parameters of ((PI-LL) − PT + TK).

Results:

We analyzed 52 patients with a mean age of 59 ± 16 years. In patients with a postoperative SVA <5cm, a smaller TK was seen when PI-LL >10° than when PI-LL<10° (15.45° vs 33.04°, P = .0004). Additionally, PT was larger when PI-LL >10° than when PI-LL <10° (25.73° vs 19.07°, P = .006). SVA correlated better with ((PI-LL) − PT + TK) ( R2 = 0.51) than with PI-LL alone ( R2 = 0.33). Lastly, there was no significant correlation between change in pre- to postoperative SVA with change in TK for all cases ( P = .73), but in cases where change in PI-LL was <10°, there was a significant correlation between change in TK and change in SVA ( P = .009).

Conclusion:

Our results demonstrate that PT and TK, and not just PI-LL, play an important role in maintaining sagittal balance when there is a PI-LL mismatch >10°.
Return to Sport for Skeletally Immature Athletes After ACL Reconstruction: Preventing a Second Injury Using a Quality of Movement Assessment and Quantitative Measures to Address Modifiable Risk Factors
Authors: Graziano Jessica , Chiaia Theresa , de Mille Polly , Nawabi Danyal H. , Green Daniel W. , Cordasco Frank A.
Published: April 2017

Background:

Reinjury rates after anterior cruciate ligament reconstruction (ACLR) are highest among young athletes, who consequently suffer from low rates of return to play. Historically, quantitative measures have been used to determine readiness to return to sport; however, they do not assess modifiable risk factors related to the quality of movement.

Purpose:

To determine the effectiveness of a criteria-based rehabilitation progression and return-to-sport criteria on efficient return to activity and prevention of second injury in young athletes post-ACLR.

Study Design:

Case series; Level of evidence, 4.

Methods:

Between December 2010 and 2013, 42 skeletally immature athletes (mean chronologic age, 12 years; range, 10-15 years) who underwent ACLR using ipsilateral hamstring tendon autograft were prospectively evaluated. All athletes progressed through a criteria-based rehabilitation progression; were assessed at specific time frames for strength, biomechanical, and neuromuscular risk factors predictive of injury; and were provided targeted interventions. The final return to sport phase consisted of quantitative testing as well as a quality of movement assessment of several functional movements with progressive difficulty and sports-specific loading. Clearance for unrestricted activity was determined by achieving satisfactory results on both qualitative and quantitative assessments with consideration for the demands of each sport.

Results:

The mean time for return to unrestricted competitive activity was 12 months. All but 3 (7%) athletes returned to their primary sport. Thirty-five athletes (83%) returned to unrestricted activity. Of the 6 (14%) who sustained a second injury, 3 (50%) were injured in sports they were not cleared for. All ACL reinjuries occurred in a cutting sport. Half of reinjuries occurred within 1 year of surgery, while the remaining occurred between 1 and 2 years. Eighty-three percent of reinjuries involved highly competitive cutting athletes.

Conclusion:

In our cohort, the combination of qualitative and quantitative data served as a good indicator for reducing risk and determining readiness to return to sport.
Turkey’s “Zero Problems with the Neighbors” Policy: Was It Realistic?
Authors: Askerov Ali
Published: April 2017

With the advancement of power in 2002, the Justice and Development Party (AKP) has introduced revolutionary policies in Turkey in various realms, including foreign affairs. The new trend in the foreign policy focused on not having problems with neighbors. This could be possible or nearly possible theoretically but eliminating century-long and deep-rooted conflicts with some of the neighbors would not be easy in practice. The new idealistic/moralistic approach necessitated new ways of policy formulation based on mutual gains and unthinkable concessions on the part of Turkey. Ankara’s new approach had given a special importance to building bridges of trust with the neighbors, which also seemed attractive to the political leaders of the neighboring states. This idealistic/moralistic approach was vulnerable to the dynamic political and economic developments in the region and the world in general. The policy did not have a power of sustainability due to the various old, new, and emerging problems around Turkey and hence, the government had to give it up gradually and take a new course of foreign policy based on realistic approaches to defend its national interests.
The Mormon Missionary: Who Is That Knocking at My Door?
Authors: Lively Robert L.
Published: April 2017

I have encountered Mormon missionaries in various regions of the United States and the world—but I never could find any detailed information about them written by a non-Mormon. I found this absence surprising, since their church has sent over 1.1 million missionaries around the world since its founding. With encouragement from my students, I, a non-Mormon, wrote the book The Mormon Missionary: Who Is That Knocking at My Door? (2015, 576 pages). This article tells the story of my interviews with nearly three hundred Mormon missionaries, my findings, and the book’s reception by the Mormon scholarly and missionary communities.
Clinical significance of somatic mutation in unexplained blood cytopenia
Authors: Malcovati Luca , Gallì Anna , Travaglino Erica , Ambaglio Ilaria , Rizzo Ettore , Molteni Elisabetta , Elena Chiara , Ferretti Virginia Valeria , Catricalà Silvia , Bono Elisa , Todisco Gabriele , Bianchessi Antonio , Rumi Elisa , Zibellini Silvia , Pietra Daniela , Boveri Emanuela , Camaschella Clara , Toniolo Daniela , Papaemmanuil Elli , Ogawa Seishi , Cazzola Mario
Published: April 2017

Publisher's Note: There is an Inside Blood Commentary on this article in this issue.
Surveying Batavia’s Graveyard: Geophysical controlled experiments and subsurface imaging of archaeological sites on an Indian Ocean coral island
Authors: Shragge Jeffrey , Lumley David , Issa Nader , Hoskin Tom , Paterson Alistair , Green Jeremy
Published: April 2017

We conducted geophysical surveys on Beacon Island in the Houtman Abrolhos archipelago offshore Western Australia, to investigate areas of archaeological interest related to the 1629 Batavia shipwreck, mutiny, and massacre. We used three complementary near-surface geophysical survey techniques (total magnetic intensity, electromagnetic induction mapping, and ground-penetrating radar) to identify anomalous target zones for archaeological excavation. Interpreting near-surface geophysical anomalies is often complex and nonunique, although it can be significantly improved by achieving a better understanding of site-specific factors including background conditions, natural variability, detectability limits, and the geophysical response to, and spatial resolution of, buried targets. These factors were not well-understood for Beacon Island nor indeed for the Australian coastal environment. We have evaluated the results of controlled experiments in which we bury known targets at representative depths and analyze the geophysical responses in terms of an ability to detect and resolve targets from natural background variability. The maximum depth of detectability of calibration targets on Beacon Island is limited to approximately 0.5 m due to significant variations in background physical properties between a thin ([Formula: see text]) and highly unconsolidated dry sand, shell, and coral layer of variable thickness overlying a sea-water-saturated sandy half-space. Our controlled measurements have implications for calibrating and quantifying the interpretation of geophysical anomalies in areas of archaeological interest, particularly in coastal and sandy-coral island environments. Our geophysical analyzes contributed to the discovery of archaeological materials and five historical burials associated with the 1629 Batavia shipwreck.
Anthropocene: Victims, Narrators, and Revolutionaries
Authors: Armiero Marco , De Angelis Massimo
Published: April 2017

The absence of a reflection on revolutionary practices and subjects is the main weakness of the radical critique of the Anthropocene. The risk is to envision the Anthropocene as a space for villains and victims but not for revolutionaries. It is crucial to challenge the (in)visibility and (un)knowability of the Anthropocene beyond geological strata and planetary boundaries. As the Capitalocene, the Anthropocene has left its traces in the bodies of people upon which the new epoch has been created. The traces of the Capitalocene are not only in geological strata but also in the biological and genetic strata of human bodies; exploitation, subordination, and inequalities are inscribed into the human body and experienced, visible and knowable by subalterns without the mediation of—many times actually in opposition to—mainstream scientific knowledge. This essay inflects the concept of Capitalocene with what we call Wasteocene, to stress the contaminating nature of capitalism and its perdurance within the sociobiological fabric, its accumulation of externalities inside both the human and the earth's body. The essay envisions the Wasteocene as a feature of the Capitalocene, especially adapted to demystify the mainstream narratives of the Anthropocene. To enhance these arguments, the essay builds on the findings of the Environmental Justice Organisations, Liabilities and Trade (EJOLT) atlas of environmental conflicts and on in-depth research on the struggles against toxic contamination in Campania, Italy.
Indolence and Illness: Scurvy, the Irish, and Early Australia
Authors: Quigley Killian
Published: April 2017

Irish men and women made up more than a quarter of the approximately one hundred and sixty thousand convicts transported from the British Isles to Australia in the period 1787-1868. They feature, in major accounts of early New South Wales, as irredeemably shiftless, and prone to escapism. And in the medical literature of convict transportation, this characterization sometimes intersects with another, specifically pathological, impression: the Irish, on account of their “habits” and “character,” appeared uniquely predisposed to scurvy. This essay explains how this intersection was established, by ships' surgeons and others, via reference to theories of constitution, which had their roots in Hippocratic thought but were revitalized and revised in eighteenth- and early nineteenth-century maritime and colonial contexts. In the literature of colonial Australia, indolence, illness, and Irishness often appear as conjoined energies, suggesting the importance of pathology and its sources—apparent or actual—for the constitution of New South Wales.
Growth and reproduction of the squid Illex coindetii Verany, 1839 in the central Mediterranean Sea
Authors: CERIOLA L. , MILONE N.
Published: April 2017

Life span, growth and cost of reproduction of Illex coindetii were examined for the first time in the southern Adriatic Sea, central Mediterranean Sea. Age and growth were investigated through statoliths reading. Cost of reproduction was explored by studying the relative investment between somatic and gonad growth. The life span of I. coindetii was less than nine months in both sexes. Females (128-234 days) showed longer life span than males (124-178 days). In both sexes the linear model best described the mantle length-at age data, while the exponential model provided the best fit to the total weight-at-age data. In terms of mantle length, females grew faster than males (average growth rate was 1.33 mm day- 1 in females and 1.00 mm day-1 in males). In terms of total weight, no significant differences were highlighted between growth curves of males and females. Mantle length, total weight, mantle weight and fin weight increased up to the latest maturity stage in both sexes. Immature and maturing individuals showed poorer body condition than mature counterparts in both sexes. Some evidences of a reproductive strategy more similar to a multiple-spawning than to a single-spawning species were found.
“New Mediterranean Biodiversity Records” (March 2017)
Authors: LIPEJ L. , ACEVEDO I. , AKEL E.H.K. , ANASTASOPOULOU A. , ANGELIDIS A. , AZZURRO E. , CASTRIOTA L. , ÇELIK M. , CILENTI L. , CROCETTA F. , DEIDUN A. , DOGRAMMATZI A. , FALAUTANO M. , FERNÁNDEZ-ÁLVAREZ F.Á. , GENNAIO R. , INSACCO G. , KATSANEVAKIS S. , LANGENECK J. , LOMBARDO B.M. , MANCINELLI G. , MYTILINEOU CH. , PAPA L. , PITACCO V. , PONTES M. , POURSANIDIS D. , PRATO E. , RIZKALLA S.I. , RODRÍGUEZ-FLORES P.C. , STAMOULI C. , TEMPESTI J. , TIRALONGO F. , TIRNETTΑ S. , TSIRINTANIS K. , TURAN C. , YAGLIOGLU D. , ZAMINOS G. , ZAVA B.
Published: April 2017

This Collective Article presents information on 22 species belonging to 5 Phyla, arranged geographically from from west to east. The new records were found in 8 countries as follows: Spain: first record of the two scarcely known nemerteans Baseodiscus delineatus and Notospermus geniculatus in Formentera; Malta: second record of the alien fish Lagocephalus sceleratus; Italy: the alien polychaete Syllis pectinans and the isopod Paranthura japonica, as well as the cryptogenic opisthobranch Anteaeolidiella lurana, were found in the fouling assemblages along the docks of the port of Livorno. New decapod records are reported from Sicily (the alien Callinectes sapidus and the native Pachygrapsus maurus) and Apulia (Percnon gibbosus and Procambarus clarkii); the lesser amberjack Seriola fasciata extended its geographical range to the Egadi Isands and Siganus luridus was documented for the first time along the Ionian coasts of Apulia and Calabria. Slovenia: the first record of the alien bivalve Brachidontes pharaonis is reported, together with a survey of up to date Adriatic records. Greece: the first record of the gastropod Rhinoclavis kochi is reported from Gavdos island. In addition, two records of endangered and rare cartilaginous fish were reported, namely, the shark Hexanchus griseus and the ray Leucoraja fullonica, as well as additional records of Siganus luridus for Lesvos and Malleus regula and Fulvia fragilis from Astypalaia. Turkey: the black wing flyingfish Hirundichthys rondeletii is reported for the very first time from the Black Sea. Egypt: the Indo-Pacific crab Halimede ochtodes is reported as established in Port Said. In addition, biometric parameters and meristic counts are reported for Anthias anthias in Damietta. Cyprus: the alien opisthobranch gastropod Bursatella leachii is reported for first time.
Data Interpolating Empirical Orthogonal Functions (DINEOF): a tool for geophysical data analyses
Authors: ALVERA-AZCÁRATE A. , BARTH A. , SIRJACOBS D. , LENARTZ F. , BECKERS J. M.
Published: April 2017

no abstract
The elephant shark methylome reveals conservation of epigenetic regulation across jawed vertebrates
Authors: Peat Julian R. , Ortega-Recalde Oscar , Kardailsky Olga , Hore Timothy A.
Published: April 2017

Background: Methylation of CG dinucleotides constitutes a critical system of epigenetic memory in bony vertebrates, where it modulates gene expression and suppresses transposon activity. The genomes of studied vertebrates are pervasively hypermethylated, with the exception of regulatory elements such as transcription start sites (TSSs), where the presence of methylation is associated with gene silencing. This system is not found in the sparsely methylated genomes of invertebrates, and establishing how it arose during early vertebrate evolution is impeded by a paucity of epigenetic data from basal vertebrates.

Methods: We perform whole-genome bisulfite sequencing to generate the first genome-wide methylation profiles of a cartilaginous fish, the elephant sharkCallorhinchus milii. Employing these to determine the elephant shark methylome structure and its relationship with expression, we compare this with higher vertebrates and an invertebrate chordate using published methylation and transcriptome data. 

Results: Like higher vertebrates, the majority of elephant shark CG sites are highly methylated, and methylation is abundant across the genome rather than patterned in the mosaic configuration of invertebrates. This global hypermethylation includes transposable elements and the bodies of genes at all expression levels. Significantly, we document an inverse relationship between TSS methylation and expression in the elephant shark, supporting the presence of the repressive regulatory architecture shared by higher vertebrates.

Conclusions: Our demonstration that methylation patterns in a cartilaginous fish are characteristic of higher vertebrates imply the conservation of this epigenetic modification system across jawed vertebrates separated by 465 million years of evolution. In addition, these findings position the elephant shark as a valuable model to explore the evolutionary history and function of vertebrate methylation.
The internet trade of counterfeit spirits in Russia – an emerging problem undermining alcohol, public health and youth protection policies?
Authors: Neufeld Maria , Lachenmeier Dirk W. , Walch Stephan G. , Rehm Jürgen
Published: April 2017

Counterfeit alcohol belongs to the category of unrecorded alcohol not reflected in official statistics. The internet trade of alcoholic beverages has been prohibited by the Russian Federation since 2007, but various sellers still offer counterfeit spirits (i.e., forged brand spirits) over the internet to Russian consumers, mostly in a non-deceptive fashion at prices up to 15 times lower than in regular sale. The public health issues arising from this unregulated trade include potential harm to underage drinkers, hazards due to toxic ingredients such as methanol, but most importantly alcohol harms due to potentially increased drinking volumes due to low prices and high availability on the internet. The internet sale also undermines existing alcohol policies such as restrictions of sale locations, sale times and minimum pricing. The need to enforce measures against counterfeiting of spirits, but specifically their internet trade should be implemented as key elements of alcohol policies to reduce unrecorded alcohol consumption, which is currently about 33 % of total consumption in Russia.
Type 2 diabetes in children and its association with obesity
Authors: Cremonesini Louise
Published: April 2017

Louise Cremonesini explores methods for countering the spread of type 2 diabetes among children
Baby boxes: Improving wellbeing outcomes in Scotland
Authors: Ross Lindsay A
Published: April 2017

The introduction of a Finnish-style baby box to Scotland could assist in closing the inequality gap by providing all children with the same start in life and careful planning and support from health visitors, says Lindsay A Ross.
Common childhood ailments: Otitis media
Authors: Tinsley Elizabeth
Published: April 2017

Otitis media is an infection of the middle ear that causes inflammation (redness and swelling) and a build-up of fluid behind the eardrum, which children can find painful and distressing. Although anyone can develop a middle ear infection, they are most common in infants aged 6–15 months. Around one in every four children experience at least one middle ear infection by the age of 10 years.
Das "Bastille"-Ereignis – Sturm auf der Sonne, im interplanetaren Raum und auf der Erde
Authors: Bamert Karin , Hofer Mirjam Y.
Published: April 2017

The Earth is constantly bombarded by ionized energetic particles originating from solar eruptions and from the galaxy. Because ionized particles can interfere with modern technology, the solar storms directly
affect human civilisation. On "Bastille Day", July 14, 2000, one of the most intense solar eruptions, or flares, of this solar cycle was observed. The shock wave generated by the coronal mass ejection of
solar material collided with the Earth's magnetosphere and triggered a severe geomagnetic storm. We analysed measurements of this phenomenon, commonly known as the "Bastille Day" event, recorded by two
particle detectors on the SOHO and ULYSSES spacecrafts. The results show the large area affected by the ionized particle storm and the acceleration processes at the shock.
Stürme überall – ein Fazit
Authors: Baccini Peter
Published: April 2017

The metaphor "storm", applied to political, social and psychological processes, is often negatively connotated. In the natural sciences, storms describe complex physical processes free of normative
views, while in art, they often refer to positive events which lead to new insights. These different meanings of the same word may indicate the difficulties in interdisciplinary work. Currently, a disciplinary
career remains the ultimate choice for young scientists, because interdisciplinary work still does not receive full academic credits. Therefore, the Swiss Academy of Sciences should promote institutions
engaged in interdisciplinary research and encourage a critical size of suitable peer reviewers.With its bilingual culture, the city of Fribourg was an ideal location for the 183rd congress of the Swiss
Academy of Sciences; a congress which focused on one metaphor – that of storm – to catalyze an interdisciplinary dialogue.
Ein vielschichtiges Bild der Alpen
Authors: Tappeiner Ulrike
Published: April 2017

Bereits die erste Auflage des Buches "Die Alpen" von Werner Bätzing, erschienen im Jahr 1984, zählt zu den Standardwerken über diesen geographischen Raum. Damit, mit weiteren Publikationen
und durch seine rege Vortragstätigkeit hat Bätzing einen wesentlichen Anteil daran, daß die Alpen von vielen persönlich oder wissenschaftlich Interessierten als Raum mit gemeinsamer
Geschichte, gemeinsamen Problemen und gemeinsamen Chancen wahrgenommen werden. Nun ist die, wie der Autor anmerkt »völlig neu konzipierte«, und mit Hardcover, exzellenter Papierqualität,
schönem Layout und reicher Bebilderung ansprechend aufgemachte zweite Auflage erschienen.
Wetter- und Klimastürme
Authors: Liniger Mark A.
Published: April 2017

Extreme weather and climate conditions can cause widespread damage to infrastructure and natural resources. This work addresses the predictability of two such events, the winter storm "Lothar" in 1999 and
the 1997/98 El Niño event. Both phenomena illustrate how the involved processes are interrelated in a non-linear manner. The predictability of such events is limited. By means of the simple dynamical
Lorenz system, we show how predictability can be improved by probabilistic forecasts, which can be applied to various kinds of weather and climate predictions. In general, the probabilistic approach increases
the benefit significantly compared to a single deterministic forecast. However, the interpretation of probabilistic forecasts needs to be handled with care and their usability depends on the particular
application.
New record of Steinernema arenarium (Artyukhovsky) (Rhabditida: Steinernematidae) from Ukraine and a note on its distribution
Authors: Yakovlev Yegor , Nermut Jiří , Půža Vladimír , Kharchenko Vitaliy A. , Mráček Zdeněk
Published: April 2017

During a survey of the biodiversity of entomopathogenic nematodes in Ukraine, a population of
Redescription of Philometra margolisi Moravec, Vidal-Martínez et Aguirre-Macedo, 1995 (Nematoda: Philometridae), a gonad-infecting parasite of the red grouper Epinephelus morio (Serranidae) in the Gulf of Mexico
Authors: Moravec František , Bakenhaster Micah D. , Leone Erin H.
Published: April 2017

The insufficiently known nematode species
Toxoplasma gondii in backyard pigs: seroepidemiology and mouse bioassay
Authors: Samico-Fernandes Erika Fernanda Torres , Samico-Fernandes Marcela Fernanda Torres , de Albuquerque Pedro Paulo Feitosa , de Almeida Jonatas Campos , de Souza Santos André , da Rocha Mota André , de Souza Neto Orestes Luiz , Mota Rinaldo Aparecido
Published: April 2017

The aim of this study was to evaluate the occurrence of
Fatal aelurostrongylosis in a kitten in Serbia
Authors: Gavrilović Pavle , Jovanović Milijan , Gavrilović Aleksandra , Nešić Slađan
Published: April 2017

This paper describes a case of aelurostrongylosis in a four-month old female domestic cat (
The Apollo Group Asteroid 2008 OS9: Discovery, Orbit, Rotation and the Yarkovsky/YORP Effects
Authors: Černis K. , Eglitis I. , Wlodarczyk I. , Zdanavičius J. , Zdanavičius K.
Published: April 2017

A project for astrometric and photometric observations of asteroids at the Baldone Observatory is described. One of the most important results of the project is the discovery of 2008 OS9, a 600 meter asteroid of the NEO Apollo group. The results of its astrometric and photometric observations at the Molėtai and Baldone observatories are presented. From the brightness variation with the 0.27 mag amplitude, a rotation period of 8.430 ± 0.005 h is determined. Close approaches of the asteroid to Earth and Venus during the next millenium are predicted. The mean values of secular changes in the semi-major axis, eccentricity and inclination are computed with and without the Yarkovsky and YORP effects. A negative value of the difference between the value of semi-major axis computed with the Yarkovsky and YORP effects and without them, da/dt, may indicate retrograde rotation of the asteroid.
Vascular calcification: the role of microRNAs
Authors: Alkagiet Stelina , Tziomalos Konstantinos
Published: April 2017

Vascular calcification represents the deposition of calcium phosphate salts in the tunica media of the vascular wall. It occurs during aging but is accelerated and pronounced in patients with diabetes mellitus, chronic kidney disease (CKD) and established cardiovascular disease. Due to the loss of elasticity of the vessel wall, vascular calcification might result in left ventricular hypertrophy and compromise coronary perfusion. Accordingly, several studies showed that vascular calcification is associated with increased risk for cardiovascular morbidity and mortality. Accumulating data suggest that microRNAs (miRs) play an important role in vascular calcification. A variety of miRs have been implicated in the development of vascular calcification, whereas others appear to play a protective role. Accordingly, miRs might represent promising targets for the prevention of vascular calcification and its adverse cardiovascular sequelae. However, given the complexity of regulation of this process and the multitude of miRs involved, more research is needed to identify the optimal candidate miRs for targeting.
Nodal length of Steklov eigenfunctions on real-analytic Riemannian surfaces
Authors: Polterovich Iosif , Sher David A. , Toth John A.
Published: April 2017

We prove sharp upper and lower bounds for the nodal length of Steklov eigenfunctions on real-analytic Riemannian surfaces with boundary. The argument involves frequency function methods for harmonic functions in the interior of the surface as well as the construction of exponentially accurate approximations for the Steklov eigenfunctions near the boundary.
Time, Space, Dummett and McTaggart
Authors: Garrett Brian
Published: April 2017

Michael Dummett’s fecund and uncharacteristically brief article “A Defence of McTaggart’s Proof of the Unreality of Time” offers a well-known interpretation of McTaggart’s proof, and makes a number of controversial claims about a range of inter-connected theses concerning time and space. I want to sort out what is plausible in what Dummett says from what is not, and identify which theses should be endorsed by A theorists and which by B theorists. It is important, even today, to get clear about these issues and their bearing on Dummett’s interpretation of McTaggart.
Subjectivity and generativity in midlife
Authors: Wojciechowska Ludwika
Published: April 2017

An important aspect of human development in midlife is, according to E. Erikson’s theory, the successful resolution of the crisis between generativity and stagnation. Generativity is understood as focusing one’s energy on productivity and creativity - the creation of new works and ideas dedicated to future generations. It is assumed that generativity results from personal needs and constitutes a response to the social expectations directed at individuals. Concern for the next generation does not go hand-in-hand with concern for the personal development of a person in midlife and this imbalance may lead to a psychological discomfort and a sense of martyrdom. Accordingly, it can therefore be concluded that a person focusing on the well-being of the social environment and neglecting her/himself is incapable of feeling that they are a subject that manages their fate and makes decisions enabling them to achieve personal psychological well-being. It could, therefore, be expected that the fulfilment of generative goals may lead to a reduction in the psychological well-being of a representative of middle adulthood. Empirical data has not confirmed this expectation.
Masculinity Ideology and Subjective Well-Being in a Sample of Polish Men and Women
Authors: Pietraszkiewicz Agnieszka , Kaufmann Michèle C. , Formanowicz Magdalena M.
Published: April 2017

Masculinity ideology is defined as a blend of cultural beliefs, types of behavior, and roles generally associated with men and boys. Previous studies have showed mixed effects of adherence to masculine ideology on men’s subjective well-being, indicating negative but also positive relationships. The present study focuses on agency, that is the core of stereotypic masculinity (Abele & Wojciszke, 2007), and its relationship to subjective well-being by analyzing data from a representative Polish sample of the European Social Survey (ESS). Participants were 1751 adults, aged 17 years and older (of whom 771 were men). A structural equation model was applied. The results demonstrated that agentic values (specifically valuing power and achievement) were good predictors of male and female subjective well-being. That is, the less men and women valued their own power and achievements, the lower their subjective well-being was. As expected, this association was stronger for men. Additionally, regardless of gender, we demonstrated that age was a negative predictor and that number of years of education a positive predictor of subjective well-being. This association was stronger for men.
Circonscript Subcutaneous Arteriovenous Malformation of the Head
Authors: Mirchevski Vladimir , Zogovska Elizabeta , Chaparoski Aleksandar , Filipce Venko , Kostov Milenko , Mirchevski Mirko Mishel
Published: April 2017

The aim of this study is to show the various possibilities to treat this rare malformation, accentuating the results of the early surgical treatment before complications.

Material: The authors present 8 cases of patients with subcutaneous arteriovenous malformations, 5 females and 3 males (age of 7, 13, 19, 23, 27, 52 and 58 years) treated in the period of 1999 until 2015 at the Clinic for Neurosurgery and the Clinic for Plastic, Aesthetic and Reconstructive Surgery in Skopje, Republic of Macedonia. This malformation has been observed by the parents in the childhood, around the age of 3 years in all cases. Local red circonscripted nodule, soft, with manually discharging tendency and varicose dilated veins have been observed in all cases, deaf on both sides in one case, while in the older case, a cavernous sinus thrombosis caused unilateral exophthalmia, hyaline indurated ophthalmic vein, vertigo, arrhythmia, heart failure and bradypsychia have been observed. The size of the malformation has been from 2.5 to 7 cm. The diagnostics was done using CT, CT-angiography and digital angiography including external carotid angiography. Endocranial arterials peduncle was present in all cases.

Results: Six cases underwent surgery, while two cases were treated with several treatments of endovascular embolization. The follow up has been ranged from 2 to 15 years. All surgically treated patients improved without recurrence, the exophthalmia, bradypsychia and the heart problems regressed, while in patients treated with endovascular non-complete occlusion the AVM decreased, but still remained.

In conclusion: The Surgical treatment remains a first option if it is possible, and as earlier as possible, while embolization is a useful tool in cases where a complete excision is not possible.
Les structures sémantiques profondes du code pénal chinois
Authors: Lin Zhu
Published: April 2017

Greimas applique aux structures narratives profondes du récit le carré sémiotique servant à représenter l’émergence de la signification à l’intérieur d’une structure. Dans le présent article, nous essayons d’extraire les structures sémantiques profondes du code pénal chinois en adaptant le carré greimassien aux spécificités du discours juridique. Du modèle sémiotique constitutionnel du code pénal à ses deux substructures, en passant par l’analyse de l’épistémé qui commande leur manifestation, nos analyses essaient de faire ressortir les spécificités typiques du discours juridique qui nous paraissent incontournables pour l’analyse sémiotique de ce type de discours particulier
Frühe Bilder in der Ontogenese
Authors: Maurer Dieter
Published: April 2017

Der vorliegende Aufsatz unternimmt den Versuch, die Morphologie früher Bilder in der Ontogenese auf der Grundlage ausgedehnter phänomenologischer und dokumentarischer Studien zusammenfassend darzustellen, im Sinne einer Revision bisheriger Darstellungen in der Literatur, welche frühe Bilder häufig unter den Bezeichnungen „Kritzeleien“ und „frühe Kinderzeichnung“ abhandeln. Mit dieser Zusammenfassung soll gleichzeitig die „Logik“, der bildhafte Begründungszusammenhang von frühen graphischen Merkmalen, Strukturbildungen und Entwicklungstendenzen deutlich werden. Die Darstellungen sind dabei in erster Linie darauf ausgerichtet, verschiedenen Bereichen der Wissenschaft wie der Praxis eine Einleitung für ein nachfolgendes vertiefendes Studium sowie für weiterführende Einschätzungen und Interpretationen früher Bilder anzubieten. In diesem Sinne sind die Darstellungen verbunden mit ausgedehnten illustrierenden Bild- und Videodokumenten, welche online frei zugänglich sind.
Comparison of the Hang High Pull and Loaded Jump Squat for the Development of Vertical Jump and Isometric Force-Time Characteristics
Authors: Oranchuk Dustin J. , Robinson Tracey L. , Switaj Zachary J. , Drinkwater Eric J.
Published: April 2017

Oranchuk, DJ, Robinson, TL, Switaj, ZJ, and Drinkwater, EJ. Comparison of the hang high pull and loaded jump squat for the development of vertical jump and isometric force-time characteristics. J Strength Cond Res 33(1): 17–24, 2019—Weightlifting movements have high skill demands and require expert coaching. Loaded jumps have a comparably lower skill demand but may be similarly effective for improving explosive performance. The purpose of this study was to compare vertical jump performance, isometric force, and rate of force development (RFD) after a 10-week intervention using the hang high pull (hang-pull) or trap-bar jump squat (jump-squat). Eighteen National Collegiate Athletic Association Division II swimmers (8 males, 10 females) with at least 1 year of resistance training experience volunteered to participate. Testing included the squat jump (SJ), countermovement jump, and the isometric midthigh pull (IMTP). Vertical ground reaction forces were analyzed to obtain jump height and relative peak power. Relative peak force, peak RFD, and relative force at 5 time bands were obtained from the IMTP. Subjects were randomly assigned to either a hang pull (n = 9) or jump-squat (n = 9) training group and completed a 10-week, volume-equated, periodized training program. Although there was a significant main effect of training for both groups, no statistically significant between-group differences were found (p ≥ 0.17) for any of the dependent variables. However, medium effect sizes in favor of the jump-squat training group were seen in SJ height (d = 0.56) and SJ peak power (d = 0.69). Loaded jumps seem equally effective as weightlifting derivatives for improving lower-body power in experienced athletes. Because loaded jumps require less skill and less coaching expertise than weightlifting, loaded jumps should be considered where coaching complex movements is difficult.
Downregulation of RBO-PI4KIIIα Facilitates Aβ42Secretion and Ameliorates Neural Deficits in Aβ42-ExpressingDrosophila
Authors: Zhang Xiao , Wang Wen-An , Jiang Li-Xiang , Liu Hai-Yan , Zhang Bao-Zhu , Lim Nastasia , Li Qing-Yi , Huang Fu-De
Published: April 2017

Phosphoinositides and their metabolizing enzymes are involved in Aβ42metabolism and Alzheimer's disease pathogenesis. In yeast and mammals, Eighty-five requiring 3 (EFR3), whoseDrosophilahomolog is Rolling Blackout (RBO), forms a plasma membrane-localized protein complex with phosphatidylinositol-4-kinase Type IIIα (PI4KIIIα) and a scaffold protein to tightly control the level of plasmalemmal phosphatidylinositol-4-phosphate (PI4P). Here, we report that RBO binds toDrosophilaPI4KIIIα, and that in an Aβ42-expressingDrosophilamodel, separate genetic reduction of PI4KIIIα and RBO, or pharmacological inhibition of PI4KIIIα ameliorated synaptic transmission deficit, climbing ability decline, premature death, and reduced neuronal accumulation of Aβ42. Moreover, we found that RBO-PI4KIIIa downregulation increased neuronal Aβ42release and that PI4P facilitated the assembly or oligomerization of Aβ42in/on liposomes. These results indicate that RBO-PI4KIIIa downregulation facilitates neuronal Aβ42release and consequently reduces neuronal Aβ42accumulation likely via decreasing Aβ42assembly in/on plasma membrane. This study suggests the RBO-PI4KIIIα complex as a potential therapeutic target and PI4KIIIα inhibitors as drug candidates for Alzheimer's disease treatment.

SIGNIFICANCE STATEMENTPhosphoinositides and their metabolizing enzymes are involved in Aβ42metabolism and Alzheimer's disease pathogenesis. Here, in an Aβ42-expressingDrosophilamodel, we discovered and studied the beneficial role of downregulating RBO or its interacting protein PI4KIIIα—a protein that tightly controls the plasmalemmal level of PI4P—against the defects caused by Aβ42expression. Mechanistically, RBO-PI4KIIIα downregulation reduced neuronal Aβ42accumulation, and interestingly increased neuronal Aβ42release. This study suggests the RBO-PI4KIIIα complex as a novel therapeutic target, and PI4KIIIα inhibitors as new drug candidates.
Association of NF-κB polymorphisms with clinical outcome of non-medullary thyroid carcinoma
Authors: Plantinga Theo S , Petrulea Mirela S , Oosting Marije , Joosten Leo A B , Piciu Doina , Smit Johannes W , Netea-Maier Romana T , Georgescu Carmen E
Published: April 2017

The NF-κB inflammatory pathway plays a major role in cancer development and clinical progression. Activation of NF-κB signaling is promoted by NFKB1 and inhibited by NFKBIA. The present study aimed to determine the relevance ofNFKB1rs4648068 andNFKBIArs2233406 genetic variants for non-medullary thyroid cancer (NMTC) susceptibility, progression and clinical outcome. This case–control and cohort study consists of a Romanian discovery cohort (157 patients and 258 controls) and a Dutch validation cohort (138 patients and 188 controls). In addition, patient cohorts were analyzed further for the association of genetic variants with clinical parameters. Functional studies were performed on human peripheral blood mononuclear cells. No associations were observed between the studied genetic variants and TC susceptibility. Although no statistically significant associations with clinical parameters were observed forNFKB1rs4648068, the heterozygous genotype ofNFKBIArs2233406 was correlated with decreased radioactive iodide sensitivity requiring higher cumulative dosages to achieve clinical response. These findings were discovered in the Romanian cohort (P < 0.001) and confirmed in the Dutch cohort (P = 0.01). Functional studies revealed that thisNFKBIArs2233406 genotype was associated with elevated TLR4-mediated IL-1β production. In conclusion, genetic variation inNFKBIA, an inhibitor of NF-κB signaling, is associated with clinical response to RAI therapy and with increased production of the pro-inflammatory cytokine IL-1β, providing a potential mechanism for the observed clinical associations. These data suggest that NF-κB signaling is involved in NMTC pathogenesis and that the inflammatory tumor microenvironment could contribute to RAI resistance.
Видова характеристика епізоотії сказу в Україні за 2011–2016 рр.
Authors: Mazur M. , Mazur N. , Polupan I.
Published: April 2017

The article presents analysis of dynamics of the animal rabies incidence and characteristics of rabies epizootic situation for the animal species in Ukraine from 2011–2016. We analyzed the laboratory research expertise, reports of regional departments of Veterinary Medicine and the State Veterinary and Phytosanitary Service of Ukraine (now State Service of Ukraine on issues of food safety and consumer protection) for the period from 2011 to 2016, and the information that is presented in the Rabies Bulletin Europe. During this period in Ukraine registered 8807 cases of rabies among 17 animal species. Analysis of rabies cases indicates that the main reservoir of rabies virus among wild animals is foxes. Fox incidence rate ranged from 38.8% in 2014 to 31.2% in 2016 from total cases of rabies. Among domestic animals, the first place in the structure of the incidence of rabies is occupied cats, part of which is 25.9% in 2014 to 32.5% in 2016. In the second place are dogs, which account for 18% in 2012 to 23.5% in 2016 of the total number of animal rabies cases. Increased incidence of domestic animals, especially in cats and dogs, are the result of an incomplete rabies vaccination coverage and direct evidence of improper performance of the current "Instructions for measures to combat and prevent of rabies."
Вплив бровітакокциду сукупно з плодами розторопші плямистої на стан імунної системи індиків за еймеріозної інвазії
Authors: Khariv I. , Gutyj B. , Hunchak V. , Slobodyuk N. , Vynyarska A. , Sobolta A. , Todoriuk V. , Seniv R.
Published: April 2017

The immune system provides resistance of the organism against bacterial and viral infections in the body of the poultry. In the intestinal mucosa of eymeria it was secrete metabolic products, that are toxic to various systems and tissues of turkeys. Eymeria, parasitizing in the gut, inhibit specific phase of immunity presented by antibodies (humoral type), reduce the activity of sensitized cells (cell type), slow down nonspecific phase of immunity, represented by various immune cells. The rapid and complete recovery of functional state of the immune system in turkeys, affected by eymeriozic invasion it was found if brovitatoxide was given if the aggregate of the fruits of milk thistle. Fruits contain group of flavius lignans named «Sylimaryn», acting immune stimulatory for the development of secondary immuno deficiencies state of body.
Meditation awareness training for the treatment of workaholism: A controlled trial
Authors: Van Gordon William , Shonin Edo , Dunn Thomas J. , Garcia-Campayo Javier , Demarzo Marcelo M. P. , Griffiths Mark D.
Published: April 2017

Background and aims

Workaholism is a form of behavioral addiction that can lead to reduced life and job satisfaction, anxiety, depression, burnout, work–family conflict, and impaired productivity. Given the number of people affected, there is a need for more targeted workaholism treatments. Findings from previous case studies successfully utilizing second-generation mindfulness-based interventions (SG-MBIs) for treating behavioral addiction suggest that SG-MBIs may be suitable for treating workaholism. This study conducted a controlled trial to investigate the effects of an SG-MBI known as meditation awareness training (MAT) on workaholism.

Methods

Male and female adults suffering from workaholism (n = 73) were allocated to MAT or a waiting-list control group. Assessments were performed at pre-, post-, and 3-month follow-up phases.

Results

MAT participants demonstrated significant and sustained improvements over control-group participants in workaholism symptomatology, job satisfaction, work engagement, work duration, and psychological distress. Furthermore, compared to the control group, MAT participants demonstrated a significant reduction in hours spent working but without a decline in job performance.

Discussion and conclusions

MAT may be a suitable intervention for treating workaholism. Further controlled intervention studies investigating the effects of SG-MBIs on workaholism are warranted.
Utilização de registros de dispensação de medicamentos na mensuração da adesão: revisão crítica da literatura
Authors: Lima-Dellamora Elisangela da Costa , Osorio-de-Castro Claudia Garcia Serpa , Madruga Livia Gonçalves dos Santos Lima , Azeredo Thiago Botelho
Published: April 2017

Resumo: O marco atual sobre a adesão à farmacoterapia compreende um conjunto de comportamentos experimentados pelo usuário em que se observa a trajetória detalhada e contínua do uso de cada dose do medicamento. Indicadores provenientes de registros de dispensação de medicamentos têm sido utilizados para a mensuração da adesão. A presente revisão visou a identificar e a caracterizar indicadores provenientes de registros de dispensação e a discutir sua adequação e limitações para mensuração da adesão. Foi realizada uma busca bibliográfica exploratória em três bases de dados a partir dos termos "adesão", "registros de farmácia/dados administrativos" e "medida" na composição dos descritores para a seleção de 81 artigos e elaboração de um quadro com a denominação, fontes, método de cálculo, descrição e interpretação do significado operacional e referencial de 14 indicadores. Tendo em vista a mais recente taxonomia da adesão proposta na literatura, concluiu-se que os indicadores encontrados podem ser úteis na identificação de pacientes com problemas relacionados ao comportamento de busca de medicamentos e na análise da persistência. A distância entre os eventos relacionados ao fornecimento e as dificuldades no seguimento da terapêutica podem influenciar a análise baseada exclusivamente no uso desses indicadores.
Mortalidade materna tardia: comparação de dois comitês de mortalidade materna no Brasil
Authors: Vega Carlos Eduardo Pereira , Soares Vânia Muniz Néquer , Lourenço Francisco Nasr Acácia Maria
Published: April 2017

Resumo: Estudo de base populacional que incluiu todos os óbitos maternos tardios da casuística do Comitê de Mortalidade Materna do Município de São Paulo e do Comitê Estadual de Prevenção da Mortalidade Materna do Paraná, Brasil. Foram comparados 134 óbitos do comitê de São Paulo com os 124 do Paraná do período 2004-2013, visando a demonstrar a magnitude e as causas de mortalidade materna tardia. Os óbitos maternos tardios representaram 13,4% do total dos óbitos maternos na casuística do comitê de São Paulo e 12,1% na do Paraná. As causas obstétricas diretas representaram 32,1% dos óbitos maternos tardios segundo casuística do Município de São Paulo e 42,1% no Paraná, sendo a principal causa a cardiomiopatia no puerpério nas duas casuísticas. O óbito ocorreu entre 43 e 69 dias após o parto em 44% dos casos em São Paulo e 39,5% no Paraná. O fator de correção para morte materna tardia foi 3,3 na casuística de São Paulo e 4,3 na do Paraná. A morte materna tardia teve relevante impacto sobre a mortalidade materna geral e a cardiomiopatia no puerpério foi a principal causa de óbito obstétrico direto tardio.