bluuebunny/crossref_metadata_2025 huggingface dataset:
Особенности метаболизма железа у пациентов с пароксизмальной ночной гемоглобинурией: результаты одноцентрового амбиспективного клинического исследования
Authors: Латышев Виталий Дмитриевич , Енневайн К. А. , Соловьева А. А. , Киценко А. Е. , Цветаева Н. В. , Лукина Е. А.
Published: January 2025

BACKGROUND. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematologic disease manifesting among others in hemolytic anemia. Due to predominantly intravascular hemolysis, iron metabolism in PNH patients is characterized by a number of features. Pathogenetic treatment with complement C5-inhibitors modifies the course of hemolysis and results in iron metabolic changes.
AIM. To characterize the serum parameters of iron metabolism in PNH patients and to evaluate T2* MRIs of the liver and kidneys.
MATERIALS & METHODS. Serum parameters of iron metabolism measured in 97 analyses and 99 T2* MRIs of the liver and kidneys were assessed in 82 PNH patients treated at the National Research Center for Hematology from 2018 to 2024. Patients were 21–76 years of age (median 39 years); there were 38 women and 44 men.
RESULTS. The analysis focused on the data from 78 PNH patients. Among non-recipients of C5-inhibitors, iron overload in liver tissue was identified in 10/38 (26.3 %) patients. In C5-inhibitor recipients, iron overload in liver tissue was found significantly more often, i.e. in 28/40 (70 %) patients. Iron overload in liver tissue was more pronounced in patients with suboptimal hematologic response to PNH therapy. A renal T2* MRI was performed in 71 patients. In all non-recipients of C5-inhibitors (n = 34), iron overload in renal tissue was detected. In C5-inhibitor recipients, iron overload in renal tissue occurred significantly less often, i.e. in 21/37 (57 %) patients.
CONCLUSION. Iron overload in renal cortex was identified in all PNH patients who were not treated with C5-inhibitors. Iron overload in liver tissue was associated with blood transfusions and suboptimal hematologic response to pathogenetic PNH therapy. In evaluating iron overload in liver and renal tissues, laboratory methods for assessing iron metabolism in PNH patients have lower sensitivity compared to T2* MRI. In PNH patients, the achievement of optimal response to C5-inhibitor treatment is associated with a decrease in severity of iron overload in renal tissue and no hepatic hemosiderosis.
Роль соматических мутаций в различных генах и проблема резистентности к ингибиторам тирозинкиназ у пациентов с хроническим миелолейкозом (обзор литературы)
Authors: Кузьмина Елена Андреевна , Челышева Е. Ю. , Бидерман Б. В. , Туркина А. Г.
Published: January 2025

The use of tyrosine kinase inhibitors (TKI) considerably improved the prognosis for most patients with chronic myeloid leukemia (CML). However, the issue of resistance to TKI therapy remains a challenge. At present, much attention is paid to the study of molecular genetic profile of tumor cells in CML patients and the role of somatic mutations in various genes, beyond BCR::ABL1, in the development of resistance to TKI therapy. New data emerge on the frequency of somatic mutations in various genes by the time of primary diagnosis of CML, commonly in the chronic phase, and on clonal changes during treatment, also when the disease progresses. Of particular interest is the role of somatic gene mutations in the transformation of CML into accelerated phase and blast crisis. Special importance is attributed to the time between the detection of somatic mutations and the registration of disease progression. This review focuses on the results of recent and most relevant studies of molecular genetic profile of CML patients at various disease stages. These studies aim to reveal the associations between somatic mutations in genes and a response to TKI therapy, as well as to assess the prognostic value of the mutations detected upon primary diagnosis and CML therapy. In future, this knowledge could be used in the clinic to optimize the therapy by decision making on the most effective TKIs and administering the targeted drugs aimed at alternative genetic abnormalities, as well as early allogeneic hematopoietic stem cell transplantation. The role of the most common somatic mutations in various genes, beyond BCR::ABL1, and the issues of disease resistance attract the attention of hematologists and basic scientists as a current and clinically relevant area of CML studies.
Прогностическое значение экспрессии галектина-1 опухолевыми плазматическими клетками и концентрации некоторых сывороточных цитокинов (IL-2, IL-6, TNF) у пациентов с моноклональной гаммапатией неопределенного значения и множественной миеломой
Authors: Козич Жанна Михайловна , Мартинков В. Н. , Зиновкин Д. А. , Пугачева Ж. Н. , Климкович Н. Н.
Published: January 2025

AIM. To study the prognostic value of the galectin-1 expression by bone marrow (BM) tumor plasma cells (PCs) and the concentration of serum cytokines (interleukins [IL-2, IL-6] and tumor necrosis factor [TNF]) in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (ММ).
MATERIALS & METHODS. The trial enrolled 129 patients: 77 patients with newly diagnosed MM (median age 64 years) and 52 patients with MGUS (median age 62.5 years) followed-up at the Republican Scientific and Practical Center for Radiation Medicine and Human Ecology from 2018 to 2023. All patients underwent general clinical examination as well as BM aspirate cytology with myelogram and iliac BM core biopsy with immunohistochemical (IHC) analysis of BM biopsy.
RESULTS. In the BM biopsy, the IHC analysis revealed a significant increase of galectin-1 expression (measured by expressing tumor PC count) in MM vs. MGUS patients (p < 0.001). Galectin-1 expression defined as expressing tumor PC count was significantly higher in patients with progressing MGUS compared to progression-free MM patients (p < 0.001). The median galectin-1 expression level was 8.5 % (Q25 0.2 %; Q75 15.7 %) in progression-free MGUS patients and 37.4 % (Q25 24.7 %; Q75 64.0 %) in progressing MGUS patients. Among MM patients, no significant differences were identified either in those with and without tumor progression. The IHC analysis of BM core biopsies in MM patients showed that high galectin-1 expression level is associated with pronounced vasculature but not with fibrotic changes, it also identified an increase in serum concentrations of IL-2 and TNF as well as a direct correlation with β2-microglobulin level. With MGUS progression into ММ, there was a direct correlation between galectin-1 expression level and serum M-protein. An increase of IL-2 concentration was registered only when MGUS progressed into ММ.
CONCLUSION. The results of this study indicate the evidence of a high level of galectin-1 expression by tumor PCs in MM. In MGUS, an increase of galectin-1 expression by clonal BM PCs was associated with the disease progression. Galectin-1 expression by clonal BM PCs can well be clinically used as a marker for MGUS progression into MM.
Эффективность и токсичность мобилизации аутологичных гемопоэтических стволовых клеток цитарабином + Г-КСФ, циклофосфамидом + Г-КСФ и плериксафором + Г-КСФ у пациентов с гематологическими злокачественными опухолями из группы высокого риска неудовлетворител
Authors: Елхова Светлана Сергеевна , Филатова Л. В. , Зюзгин И. С. , Волчёнков С. А. , Крамынин Л. А. , Семиглазова Т. Ю.
Published: January 2025

AIM. To compare the efficacy and toxicity of various regimens of autologous hematopoietic stem cell (HSC) mobilization (cytarabine + G-CSF, cyclophosphamide + G-CSF, and plerixafor + G-CSF) in hematologic malignancy patients with predicted poor HSC collection.
MATERIALS & METHODS. This retrospective study compared the results of autologous HSC mobilization in peripheral blood of 87 hematologic malignancy patients with predicted poor collection. Out of them, 36 patients received cytarabine 400 mg/m2/12 h IV on Day 1 and Day 2 combined with G-CSF 10 µg/kg SC from Day 5 to the last apheresis. In 18 patients, to mobilize autologous HSCs, cyclophosphamide 2–4 g/m2 IV on Day 1 + G-CSF 10 µg/kg SC also from Day 5 were used. The third regimen of autologous HSC mobilization (n = 33) started with G-CSF 10 µg/kg/day SC on Days 1, 2, 3, 4, and 5, and plerixafor 0.24 µg/kg/day SC was administered on Day 5. The analysis focused on the data from 27 classical Hodgkin lymphoma (cHL), 44 non-Hodgkin lymphoma (NHL), and 16 multiple myeloma patients. The median age was 48, 33, and 55 years, respectively.
RESULTS. The median CD34+ cell collection was 8.1 × 106/kg body mass in cytarabine + G-CSF recipients vs. 6.5 × 106/kg in cyclophosphamide + G-CSF and 2.8 × 106/kg in plerixafor + G-CSF recipients (p < 0.0001). Most common complications were thrombocytopenia grade 4 (in 44 % of cytarabine + G-CSF and 6 % of cyclophosphamide + G-CSF recipients; p = 0.004) and neutropenia grade 4 (in 42 % of cytarabine + G-CSF and 22 % of cyclophosphamide + G-CSF recipients; p = 0.23).
CONCLUSION. Cytarabine + G-CSF mobilization of autologous HSCs can well be considered to be an effective and safe regimen for cHL and NHL predicted poor mobilizers. This conclusion, however, does not apply, for a number of reasons, to plasma cell tumor patients. For this category, the determination of an optimal autologous HSC mobilization regimen still remains a highly relevant issue.
Поражение костей у взрослых пациентов с болезнью Гоше I типа: распространенность, клинические особенности, костно-суставные осложнения и проблемы инвалидизации
Authors: Мамонов Василий Евгеньевич , Чабаева Ю. А. , Пономарев Р. В. , Лукина Е. А.
Published: January 2025

BACKGROUND. Although highly effective enzyme replacement therapy (ERT) for Gaucher disease (GD) is accessible and affordable, orthopedic issues in patients appear often to be the main factor leading to their disability. Bone lesions are essentially observed in 100 % of GD patients. The nature and severity of bone and joint changes, however, are reported to be extremely heterogeneous, whereas their incidence and clinical features have until now remained underresearched.
AIM. To assess the incidence and clinical value of bone and joint lesions which complicate the course of GD type 1 with bone involvement.
MATERIALS & METHODS. This trial enrolled 267 GD type 1 patients aged 17–85 years (median 38 years), who were followed-up at the National Research Center for Hematology from 2004 to 2024. There were 109 men and 158 women. The analysis focused on the following MRI findings: bone marrow infiltration (BMI), Barnett-Nordin cortical index (BNI), bone deformity, osteolytic and osteonecrotic lesions, as well as orthopedic pathologies progressing to disability.
RESULTS. BMI was identified in 213/267 (79.8 %) patients. Erlenmeyer flask-like femoral expansion was observed in 95 % patients (n = 254). The mean BNI was 42.9 % (the normal BNI in adult population exceeds 45 %). Low BNI values were associated with osteolytic lesions, disability, and BMI. No significant association of decreased BNI was seen with osteonecroses. The incidence of osteolytic lesions was 11.2 % (n = 30). New osteolytic lesions were reported neither in ERT nor in substrate reduction therapy recipients. Medullary osteonecrosis was detected in 206/267 (77.15 %) patients, and epiphyseal osteonecrosis was identified in 74/267 (27.72 %) patients. Along with osteonecroses, in contrast to osteolytic manifestations, new lesions (n = 8) were reported to occur under long-term (> 5 years) ERT. The rate of bone fractures was 6.7 % (n = 18). In 18 patients, 64 fractures were observed at various locations. Disability associated with bone and joint complications of GD occurred in 58/267 (21.72 %) patients. After reconstructive surgery, including total articular replacement arthroplasties, 37 patients achieved complete functional recovery.
CONCLUSION. Bone changes are essentially observed in all adult patients with GD type 1. However, clinical severity and disability of patients depend on secondary bone and joint complications, among them arthroses resulting from epiphyseal osteonecrosis, pathologic fractures, bone and joint infections. These complications developing on effective ERT were identified in 67/267 patients, which accounted for 25 %.
SOCKET PRESERVATION - A REVIEW
Authors:   Professor and Head, Department of Prosthodontics, Royal Dental College, Palakkad, Kerala., Raghavan Rohit , P.A Shajahan ,   Professor, Department of Prosthodontics, Royal Dental College, Palakkad, Kerala., Rajsree B.M ,   Post Graduate Student, Department of Prosthodontics, Royal Dental College, Palakkad, Kerala.
Published: January 2025

After tooth extraction, the jaw bone has a natural tendency to become narrow, and lose its original shape because the bone quickly resorbs, resulting in 30-60% loss in bone volume in the first six months.Socket preservation can reduce the need for later bone augmentation. By reducing bone resorption and accelerating bone formation it increases implant success and survival.
MAGNETOSPHERIC DISTURBANCES IN GNEVYSHEV GAPS: CASE OF SOLAR CYCLES 20 TO 24
Authors:   Assistant, Institut de lEnseignement etde la Formation Techniques et Professionnels, Ecole Normale Superieure, Koudougou, Burkina Faso., GNANOU Inza , KABORE Salfo ,   Assistant Professeur, Department of Physics, Universite Norbert ZONGO, Koudougou, Burkina Faso., KONATE Moustapha ,   Assistant Professeur, Department of Physics, Universite Nazi BONI, Bobo-Dioulasso, Burkina Faso., Fatao CISSE Abdoul ,   PhD student, Department of Physics, Universite Norbert ZONGO, Koudougou, Burkina Faso., ZOUNDI Christian ,   Senior Lecturer, Department of Physics, Universite Norbert ZONGO, Koudougou, Burkina Faso., OUATTARA Frederic ,   Full Professor, Department of Physics, Universite Norbert ZONGO, Koudougou, Burkina Faso.
Published: January 2025

Time dependence of many solar activity factors and related phenomena shows a highest double-peak structure around sunspot maximum during the maximum phase of the 11-year solar cycle. Highly variable conditions on the Sun persist throughout the phase maximum of solar activity. A distinctive minimum around this phase maximum, called the Gnevyshev Gap or GG forms a kind of separating matrix between ascending and descending phases of a solar cycle (SC). This article gives some details on the disturbances experienced by our magnetic shield (Earths magnetosphere) during the last five complete solar cycles. Using a statistical approach, solar parameters and magnetic indices were analyzed over a discontinuous period of 125 days, having recorded the High-Speed Solar Wind (HSSW). As they pass through the interplanetary medium, highly energetic HSSW particles become hostile to all humanity and its society, which has become too technological. Our results show that solar activity is influenced by factors specific to each SC, but general structure of daily variations remains stable in GG. An asymmetry between the activity of the poloidal component of the solar magnetic field and that of HSSW was revealed over all solar cycles 20 to 24. Of these cycles, SC_22 was the most magnetically dipolar and the cycle with the most non-polar coronal holes. The time dependence of HSSW also shows two trends (increasing and decreasing). The gradually increasing HSSW trend induces North/South fluctuations in the Bz component of the Interplanetary Magnetic Field (IMF-Bz). These fluctuations are due to the emergence of new active regions of the Sun in the early morning and late night. On the other hand, rapidly decreasing HSSW trend inflicts southern stability on IMF-Bz. Whatever the period of solar cycle, IMF-Bz and EM (convective electric field) progress inversely. This suggests that in GG, solar wind/Earth magnetosphere interaction is not responsible for magnetospheric plasma circulation. Thus, GG offers a crucial period of relative calm in the terrestrial solar system, ensuring the absence of harmful phenomena in the terrestrial environment.
FACTEURS INTERVENANTS DANS LE DELAI OPERATOIRE APRES FRACTURE DU COL FEMORAL CHEZ LE SUJET AGE
Authors: Bouya Bouya , Elbouti A. , Najout H. , Azzouzi A. , Jaafari A. , Bensghir M.
Published: January 2025

Femoral neck fracture is an evolutionary step in the life of older patients. The prolongation of the operating time increases morbidity and mortality. All patients admitted to the emergency department for femoral neck fracture were included. Patients were divided into two groups according to intervention time (group 1 <48 h, group 2 > 48h). All demographic data (age, sex, ASA class) as well as the nature of treatment were noted. A Postoperative follow-up was done over the course of 3 months.The aim of our study is to analyze the Factors involved in operating delay after femoral neck fracture in elderly patients.
CLOUD-BASED AI AND MULTIVARIATE OPTIMIZATION METHODS FOR REAL-TIME SENTIMENT ANALYSIS ON SOCIAL MEDIA
Authors: A. Kakani Tapankumar
Published: January 2025

Social media has emerged as a widely used platform for individuals and businesses to share updates, opinions, and emotions. Real-time sentiment analysis of social media data provides valuable insights, enabling organizations to make informed, data-driven decisions. However, analyzing vast amounts of social media data in real-time presents significant challenges, requiring high computational power and advanced analytical capabilities. This is where cloud-based AI and multivariate optimization techniques become essential. Cloud-based AI leverages the scalability and speed of cloud computing to process large volumes of data efficiently in real-time. The multivariate optimization model enhances the analysis by handling complex, diverse datasets and evaluating multiple variables simultaneously. This research focuses on delivering a unified framework that performs real-time sentiment analysis, and the system integrates cloud-based AI with multivariate optimization strategies to automatically collect, process, and analyze social media data in real-time, delivering actionable insights with improved accuracy and efficiency.
PRIMARY BRONCHOGENIC CANCER IN NON-SMOKERS: A CASE SERIES
Authors:   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco., Amiali R. , Karhate M. ,   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco., Senhaji L. ,   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco., Serraj M. ,   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco., Elbiaze M. ,   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco., Alami B. ,   Department of Radiology, University Hospital Center Hassan II, Fez, Morocco., Smahi M. ,   Department of Thoracic surgery, University Hospital Center Hassan II, Fez, Morocco., Benjelloun MC. ,   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco., Amara B. ,   Department of Pneumology, University Hospital Center Hassan II, Fez, Morocco.
Published: January 2025

Primary bronchopulmonary cancer (PBPC) in non-smokers, particularly among women, is on the rise. This study aims to characterize lung cancer in non-smokers in the FÃ¨s-MeknÃ¨s region, where traditional wood-burning practices are common. A retrospective analysis of 561 bronchogenic cancer cases from 2020 to 2024 showed that 13.9% of patients were non-smokers, predominantly women, with nearly half from rural areas. Environmental exposure to wood smoke was noted in 42.3% of non-smokers. Adenocarcinoma was the most common histological type (74.35%), followed by squamous cell carcinoma. Most patients were diagnosed with metastatic disease and received palliative care. This highlights the need for multicenter studies to improve personalized management strategies and outcomes for patients with non-small cell lung cancer (NSCLC).
A RANDOMIZED CONTROLLED TRIAL BETWEEN LOCAL INJECTION OF METHYLENE BLUE VERSUS NORMAL SALINE FOR MANAGEMENT OF PAIN IN POST HEMORRHOIDECTOMY PATIENTS- A COMPARATIVE STUDY
Authors:   Senior Resident Department of General Surgery, BMC RI Bangalore., Babu Spoorthy , C.V Abhishek ,   Assistant Professor, Department of General Surgery, Adichunchangiri Institute of Medical Sciences, ACU., Shetty Kavana ,   AdichunchangiriInstitute of Medical Sciences, ACU.
Published: January 2025

Background: Hemorrhoids have been an ailment to mankind since time immemorial. Treatment of hemorrhoids has evolved since but the constant complaint of the patient with any mode of surgical treatment is the post operative pain. Different analgesics have been tried locally and systemically to relieve the pain. Methylene blue is a well known drug for treating methemoglobinemia and also a dye used for various surgical procedures. Methylene blue is also has analgesic property and is being used in this study to minimize the post operative pain after Milligan Morgan hemorrhoidectomy.

Aims And Objectives: To compare local injection of methylene blue versus normal saline in the post operative pain management along with length of hospital stay in patients undergoing conventional Milligan Morgan hemorrhoidectomy.

Methodology: 51 cases where randomized into 2 groups by systematic randomization 26 cases were allotted study group who received 4 ml 1% methylene blue and 16 ml 0.5% bupivacaine subcutaneously around the hemorrhoid on table before the procedure and 25 patients were allotted control group will receive 16 ml 0.5% bupivacaine and 4 ml saline without methylene blue similarly and regular Milligan Morgan hemorrhoidectomy is performed after. Each hemorrhoidal pile received 4ml of the titrated mixture. Post operatively pain is assessed by the visual analogue scale and the amount of analgesics required by the patient up to 2 weeks is calculated.

Results: The post operative pain assessed on POD-3 and POD-7 between the two groups was found to be significant with a p value of 0.0001 and 0.0002 respectively with significant. The mean length of hospital stay for study group was 2.269 days and in the control group was 3days with a significant p value of 0.0120. 1 patient in study group needed additional analgesics and 8 patients in control group needed additional analgesics. 2 patients in each of the study and control groups developed acute retention of urine out of the which 1 patient developed greenish discoloration of urine which resolved spontaneously. Conclusion:Methylene blue acts as a good analgesic which reduces the morbidity for the patient and hence the patient can resume daily activities faster.
EFFECT OF DIFFERENT TYPES OF BIOCHAR ON HEAVY METAL BIOACCUMULATION BY LETTUCE AND HUMAN FOOD POISONING RISK
Authors:   Institute of Environmental Sciences and Rural Development, Daniel Ouezzin COULIBALY University (UDOC), 01 BP 176 Dedougou, Burkina Faso., Senou Issaka ,   Soil Fertility Research and Study Laboratory (LERF), Institute of RuralDevelopment (IDR), Nazi BONI University. BP 1091 Bobo-Dioulasso (Burkina Faso)., Yoni Moise ,   Institute of Environmental Sciences and Rural Development, Daniel Ouezzin COULIBALY University (UDOC), 01 BP 176 Dedougou, Burkina Faso.,   Soil Fertility Research and Study Laboratory (LERF), Institute of RuralDevelopment (IDR), Nazi BONI University. BP 1091 Bobo-Dioulasso (Burkina Faso)., Ouedraogo Hamza ,   Soil Fertility Research and Study Laboratory (LERF), Institute of RuralDevelopment (IDR), Nazi BONI University. BP 1091 Bobo-Dioulasso (Burkina Faso)., B. Nacro Hassan ,   Soil Fertility Research and Study Laboratory (LERF), Institute of RuralDevelopment (IDR), Nazi BONI University. BP 1091 Bobo-Dioulasso (Burkina Faso).
Published: January 2025

The objective of this study was to evaluate the impact of biochar application on the reduction of heavy metal contamination in soils and their bioaccumulation in lettuce. The study was carried out in Bobo-Dioulasso, Burkina Faso. Lettuce was grown in pots containing contaminated soil amended with three different types of biochar at three different doses. At maturity, the lettuce was harvested and the concentration of heavy metals in various organs was determined. The results showed that in terms of bioaccumulation in lettuce, the roots showed the highest accumulation of heavy metals, especially copper and zinc, with peak concentrations of 55.72 mg/kg for copper and 193.13 mg/kg for zinc. Cadmium was not detected in any part of the plant. The modelling results indicate that biochar application can effectively reduce the heavy metal hazard quotient, particularly in children and adolescents. To illustrate, a dose of 1 t/ha of chemically activated biochar was observed to reduce the hazard quotient for copper, lead and zinc in children by 0.06, 0.23 and 0.13 respectively. Significant reductions were also observed in adolescents and adults, with a maximum reduction of 0.39 for lead in adolescents. The chemically activated biotankswere found to be the most effective in reducing the above risk, followed by the physically activated biotanks. The study highlights the effectiveness of biochar, particularly in the context of reducing heavy metal contamination of crops and the associated risk of food poisoning, especially in vulnerable populations such as children.
INTERET DE LA JET VENTILATION AU COURS DE LA LARYNGOSCOPIE DIRECTE EN SUSPENSION
Authors: Bouya Bouya , El Jaouhari SD. , Najout H. , Elbouti A. , El Wali A. , Bensghir M.
Published: January 2025

Jet ventilation is a technique that permits gas delivery with low current volume using high velocity through a small diameter injector. It can be administered using different techniques. It is a prospective study carried out in the operating theater of the Mohamed V military training hospitalincluding patients who have undergone suspension laryngoscopy for diagnostic or therapeutic purposes. All patients were subglottically ventilated by high frequency jet ventilation. The anesthesia was induced and maintained by propofol and remifentanil in TIVA mode, intubation and surgical difficulties, hemodynamic variations as well as respiratory complications and post-operative incidents were noted.The purpose of our work was to evaluate the interest of jet ventilation during suspension laryngoscopy procedures.
ASSESSMENT AND EVALUATION OF LIFESTYLE FACTORS IMPACTING GLYCEMIC CONTROL
Authors:   Department of Computer Science, National Defence Academy, Pune, India., Kaur Ravinder
Published: January 2025

Glycemic Control is a major determinant for people with prediabetes and diabetes. Lifestyle factors plays major role in diabetes.It influence and affect the regulation of blood sugar levels.Adopting a balanced lifestyle is a critical determinant of both physical health and economic well-being.Poor health often reflects an individuals sedentary lifestyle.Every individual should prioritize their health. An unhealthy lifestyle is a gateway to diseases. These diseases can only be managed and controlled but cannot be cured. Diabetes is a progressive condition that tends to worsen over time, leading to increased complications. Technology advances are a blessing to mankind for managing the health in a proper way. Machinelearning, which is a subset of Artificial Intelligence is aiding medical field to identify the crucial features that are very relevant to diseases. In this paper the lifestyle features are identified that results in the major complications in diabetic population.
Knowledge sharing and turnover intention of librarians in private university libraries in southern Nigeria
Authors: Fasola Omobolanle Seri , Popoola Sunday Olanrewaju
Published: January 2025

Purpose. This research aims to investigate whether or not knowledge sharing would predict the intention to voluntarily leave a work place of librarians in private universities in southern states of Nigeria.
Methodology. The survey research design of the correlational kind was used for this study to test the relationship between the variables. The sampling technique used total enumeration of the 308 librarians in all 46 private universities in Southern Nigeria. The instrument used was a questionnaire which was distributed physically and via Google Forms. The data analysis technique was simple statistics of percentages, mean and standard deviation to answer the research questions and Pearson Product Moment Correlation (PPMC) for the hypothesis.
Results and discussion. The results showed that knowledge sharing level of the respondent was high, they shared knowledge using informal channels and face to face interactions accounted for occasions they shared knowledge. It was also revealed that the turnover intention of the librarians was high. The results of the correlation test revealed that there was a negative correlation between knowledge sharing and turnover intention.
Conclusions. The research results concluded that there was a significance negative relationship between knowledge sharing and turnover intention. This indicates that when knowledge sharing is high, the turnover intention of the librarians will be low. Improving the knowledge sharing attitudes of librarians through formulation of knowledge sharing policies that encourage knowledge sharing practices will lead to a decrease in turnover intention of the librarians.
Merancang sistem keamanan berbasis face recognition pada layanan sirkulasi perpustakaan
Authors: Murdani Hati , Bella Elsa Listia , Fatwanto Agung
Published: January 2025

Purpose. This article aims to design a security system for library circulation services based on facial recognition, focusing specifically on collection lending services. The proposed system seeks to usher libraries into a new era where efficiency and security are prioritized, while also serving as an example of innovation in modern library circulation security systems.Methodology. The system design follows an object-oriented approach, employing the UML language with activity diagrams and use case diagrams to model the processes.Results and discussion. The proposed system includes a use case diagram that outlines system activities and the relationships between actors and the system, as well as an activity diagram that details the structured flow of the book borrowing process, integrating facial recognition technology.Conclusions. Facial recognition is proposed as a means to enhance the security of library book borrowing processes by providing automatic, dual-layer identity verification. By implementing facial recognition in the circulation service security system, libraries are expected to prevent unauthorized access and misuse while improving service efficiency.
A recent lower limb exoskeleton robot for gait rehabilitation: a review
Authors: Rakhmatillaev Javlonbek , Bucinskas Vytautas , Juraev Zafar , Kimsanboev Nodirbek , Takabaev Umidjon
Published: January 2025

Human rehabilitation improved significantly after traumas, surgery, or accidental cross-link events with human health. During the last six decades, exoskeletons have played a significant role in human activities related to body training and post-trauma or surgery treatment, especially in gait rehabilitation. The main goal of rehabilitation training is to restore patients’ physical abilities to average by improving and monitoring their posture and gaining weight. In this paper, a classification of various types of exoskeletons is provided, a comparison between the different lower limb exoskeletons for gait rehabilitation presents, the gait anatomy, mechanical design, and control strategy for the prototype of lower limb exoskeleton studies, and the end, some concluding remarks are stated that may be useful for future work. The paper concludes with conclusions and a significant reference list.
Exploring Helplessness and Stress Coping Strategies Among Sexual Minority: A Cross-Sectional Study
Authors:   Department of Humanities and Social Sciences, VNIT, Nagpur, Verma Priyambada K. , Deshpande Yogesh
Published: January 2025

The study was conducted on transgender and gay individuals to explore whether the two groups differ on Stress Coping Strategies and Helplessness. The study also assessed the correlation between their Stress Coping Strategies and Helplessness. The study was conducted on 159 participants, 72 gay, and 87 transgender individuals. The data was subjected to correlation and t-test, assuming unequal variance. The correlational analysis revealed that ‘outer wall strategy’ had a negative correlation with ‘inadequacy’ (-0.41), ‘coping difficulties’ (-0.39), and ‘failure to invariants and negative events’ (-0.26) and a positive correlation with ‘problem avoidance and low cognition’ (0.24); ‘diet control’ had a negative correlation with ‘inadequacy’ (-0.29), ‘coping difficulties’ (-0.24) and ‘failure to invariants and negative events’ (-0.23) and ‘avoidance’ had positive correlation with ‘syndrome of cognitive motivational disturbances’ (0.28) and negative correlation with ‘coping difficulties’ (-0.27) and ‘anxious over concern and fruitless tendency to worry’ (-0.20). Further, the findings revealed that transgender individuals (112.85) scored significantly higher on Stress Coping Strategies as compared to gay individuals (101.30). However, there was no significant difference between gay (65.54) and transgender (64.93) with respect to helplessness.
Proteomics Analysis of Five Potential Plasma-derived Exosomal Biomarkers for Acute Myocardial Infarction
Authors: Xu Shasha , Zhai Yi , Wang Chen , Zhang Yang , Liu Xiaowei , Jiang Jianjun , Mi Yafei
Published: January 2025

Aims:

This study was to explore the relationship between plasma exosomes
and Acute myocardial infarction (AMI).

Background:

Acute myocardial infarction (AMI) is one of the most common cardiovascular
complications. Recent studies have shown that exosomes play a crucial role in the
development and progression of cardiovascular diseases. However, there is a lack of relevant
research on the relationship between plasma exosomes and AMI.

Objective:

This study was designed to explore the relationship between plasma exosomes
and AMI.

Methods:

This retrospective study collected the basic clinical data of patients with AMI
(n = 10), stable angina pectoris (SAP, n = 10), and noncoronary heart disease (CON, n =
10) at the Department of Cardiovascular Medicine at Taizhou Hospital (Zhejiang, China,
2021.01 to 2021.12). Proteomics was used to systematically screen the differential
proteins of plasma exosomes in patients with clinical AMI, SAP, and CON. Then, the results
were further verified using parallel reaction monitoring (PRM).

Results:

Five of all the differentially expressed proteins (DEPs) were quantified by
PRM. Compared with the CON group, heparin cofactor 2 (SERPIND1), mannan-binding
lectin serine protease 1 (MASP1), ficolin-2 (FCN2), and α1-Microglobulin/bikunin
precursor (AMBP) were upregulated in patients with AMI and SAP, with a higher expression
in AMI than in SAP. Additionally, human leukocyte antigen (HLA-C) was
downregulated in both exosomes and plasma.

Conclusion:

The expression of four plasma exosome biomarkers in AMI and SAP patients
was higher than that in noncoronary heart disease (NCHD) patients. HLA-C was
downregulated in both exosomes and plasma, showing a potential to serve as a new candidate
target for the detection and therapy of AMI.
Predicting microRNAs and their Target Genes Involved in Sepsis Pathogenesis
by using Bioinformatics Methods
Authors: Musavi Maryam , Haftcheshmeh Saeed Mohammadian , Fazel Hadi , Momtazi-Borojeni Amir Abbas
Published: January 2025

Introduction:

Sepsis, like neutropenic sepsis, is a medical condition in which our body overreacts
to infectious agents. It is associated with damage to normal tissues and organs by the immune system, which
leads to the spread of inflammation throughout our body. Of note, microRNAs (miRNAs) have been found to
have a critical role in the sepsis progression. Such miRNAs are registered in the miRNA databases, such as
Gene Expression Omnibus (GEO), with a specific identifier and unique characteristics. There is also computational
software, such as TargetScan, that are broadly employed for the analysis of miRNAs, including their
identification, target prediction, and functional analysis.

Methods:

The current In-silico study aimed to predict miRNAs involved in sepsis progression. To this end, the
GEO database was employed to find the sepsis-related genome profile. Afterward, down-regulated genes were
selected for further bioinformatics analysis with the assumption that their decreased expression is associated
with an increased sepsis progression. The miRNAs complementary to the selected genes were then predicted
using TargetScan software. Based on the current In-silico analysis, seven miRNAs, including hsa-miR-325-3p,
hsa-miR-146a-3p, hsa-miR-126-5p, hsa-miR-22-3p, hsa-miR-223-3p, hsa-miR-145-5p, and has-miR-181 family,
were predicted to participate in sepsis pathogenesis. Among the predicted miRNAs, hsa-miR-325-3p has
not been previously predicted or validated to be involved in septic conditions.

Results:

Our prediction results showed that hsa-miR-325-3p may target genes implicating in both anti-(ETFB
gene) and pro-inflammatory (TCEA1 and PTPN1 genes) responses, suggesting it is an immune hemostasis regulator
during sepsis inflammation. Although the role of other predicted miRNAs has been already validated in
the sepsis pathogenesis, the current study predicted new targets of these miRNAs, which have not been reported
by previous in-silico or experimental studies on sepsis and other pathogenic conditions. Notably, other miRNAs,
including hsa-miR-146a-3p, hsa-miR-126-5p, hsa-miR-22-3p, hsa-miR-223-3p, and hsa-miR-145-5p
were predicted to target genes participating in inflammatory responses, including BLOC1S1, POLR2G, PTPN1,
TCEA1, and CCT3.

Conclusion:

In conclusion, the results of the present study can provide promising targets as therapeutic and diagnostic
tools to treat and manage inflammation sepsis, such as neutropenic sepsis. However, these findings
should be further evaluated in experimental studies to find their exact effects and underlying mechanisms.
Exploring the Therapeutic Potential of Natural Plants in Modulating
Molecular and Cellular Pathways Involved in Diabetic Neuropathy:
Mechanism and Biochemical Evaluation
Authors: Ali Zeeshan , Bhandari Uma
Published: January 2025

Diabetic Neuropathy (DN) is a widespread and severely debilitating consequence of diabetes mellitus
that impairs function, causes discomfort, and damages peripheral nerves. Numerous molecular pathways
are involved in the pathogenesis of DN, including cyclooxygenase, polyol, protein kinase C, and inflammatory
pathways. These molecular pathways may be responsible for the mechanism behind the onset and development
of DN. The metabolic profile can be evaluated by examining the molecular mechanisms that connect diabetes
to certain biochemical indicators. Historically, the use of plants and herbs as medicine has been highly
valued in many populations. These traditional sources, either alone or in combination with contemporary
drugs, are being studied by modern medicine for their potential applications in managing and treating diabetic
neuropathy. The efficacy and potential negative effects of an herb are largely dependent on its purity and
provenance. Rich supplies of bioactive chemicals with particular pharmacological qualities that don't have negative
side effects can be found in many plants. Some phytoconstituents with antidiabetic properties are found
in medicinal plants, including terpenoids, saponins, flavonoids or carotenoids, alkaloids, and glycosides. We
conclude with the statement that developing novel therapeutic procedures for the therapy of DN would be aided
by the effective manipulation of common molecular pathways.
Application of Chitosan-based Nanogel in Cancer Nanomedicine
Authors: wang yue , Lou Xiaoli , Yang Liyuan , Hou Yanqiang
Published: January 2025

Chitosan is a kind of natural material with many unique physicochemical and biological properties
related to antibacterial, antioxidant, and chelating. In recent years, chitosan-based nano gels (CS-NG) have
been widely used in the field of cancer nanomedicine due to their excellent characteristics including biodegradability,
biocompatibility, flexibility, large surface area, controllability, high loading capacity, and especially it
can be engineered to become stimuli-responsive to tumor environments. In this review, we summarized the
main synthesis approaches of CS-NGs including radical polymerization, self-assembly, microemulsion, and
ionic gelation methods. These novel CS-NGs are applied in cancer nanomedicine serving as drug delivery,
gene delivery, and bioimaging. Besides, we proposed our perspectives regarding the clinical development of
CS-NGs cancer nanomedicine applications.
The Application of Hydrogels in the Treatment of Intrauterine Adhesions
Authors: Rajabloo Yasamin , Al-Asady Abdulridha Mohammed , Akbarzadeh Hanieh , Avan Amir , Khazaei Majid , Ryzhikov Mikhail , Hassanian Seyed Mahdi
Published: January 2025

Intrauterine Adhesions (IUA) are a significant cause of infertility and miscarriage, often resulting
from trauma to the endometrium. While hysteroscopic adhesiolysis is the primary treatment, the use of hydrogels
as anti-adhesion barriers and drug delivery systems is gaining traction for improving patient outcomes.
This review aims to explore various hydrogel types, their role in tissue repair, and the integration of stem cell
therapy. Recent advancements in biomaterial scaffolds have demonstrated potential in preventing adhesion recurrence
and promoting endometrial regeneration. These emerging treatments provide promising avenues for
enhancing the efficacy of traditional therapies in IUA management.
Applications of Selectfluor in Organic Synthesis-A Quadrennial Update
Authors: Varala Ravi , Seema Vittal , Kamsali Murali Mohan Achari , Hussein Mohamed , Alam Mohammed Mujahid
Published: January 2025

Selectfluor, bis(tetrafluoroborate)[1-chloromethyl-4-fluoro-1,4-diazoniabicyclo-[2.2.2] octane] is an
extraordinarily stable solid with exceptional properties, such as strong solubility and stability in polar solvents,
minimal toxicity, excellent thermal stability, and utility as an oxidant. One of the electrophilic fluorinating
compounds that is most frequently employed in fluorination reactions is Selectfluor. In this mini-review, we
have briefly updated the various applications of Selectfluor in organic synthesis, particularly in C-C, Cheteroatom
and heteroatom-heteroatom bond formation reactions from mid-2020 to date. In addition to these,
Selectfluor found useful in heterocyclic ring formations, demethylation, deoxygenation and other miscellaneous
reactions. The results that have been published thus far show how extraordinarily promising Selectfluormediated
organic molecule skeleton assembly events can be. Visible light, electrochemical, and nano-based
reactions still have a lot of room for growth and application, despite the noteworthy advances in these domains.
The compilation is subdivided based on the type of reaction/function of Selectfluor organic transformation.
A Review: Synthetic Pathways and Biological Activities of Oxo-imidazoline Derivatives in New Millennium
Authors: Sharma Vipasha , Nain Sumitra
Published: January 2025

Imidazoline is often a heterogeneous 5-membered ring structure with two nitrogen atoms. The heterocyclic
compounds with an imidazoline moiety are a promising scaffold for investigating medicinal potential.
The imidazoline nucleus with an oxo group at the 5th, 2nd, or 4th position exhibits a wide spectrum of antibacterial
and antifungal activity, as well as antiviral, anti-inflammatory, anticancer, analgesic, antihypertensive,
antioxidant, and enzyme-inhibiting properties. Oxo-imidazoline derivatives are a fascinating class of chemicals
that have attracted a lot of research recently because of their numerous biological actions. The primary objective
of this paper is to review the synthesis and diverse biological activity of oxo-imidazoline derivatives literature
from previous years. The synthesis of oxo-imidazoline derivatives is a prominent topic of study in organic
chemistry because of their wide range of biological activity and possible medical uses. This review provides an
extensive overview of synthetic pathways employed to prepare oxo-imidazoline derivatives with excellent biological
activities. Oxo-imidazoline derivatives are synthesized using a variety of techniques, including oxidative
cyclization, amino acid cyclization, base-catalyzed, diamine ring closure metal-catalyzed cyclizations, and so
on are discussed in this review. This review also emphasizes the importance of synthetic methodology development
in enabling efficient access to oxo-imidazoline derivatives and their analogs, allowing for further investigation
of their biological and pharmacological properties. This review also aims to provide a comprehensive
overview of the various biological properties such as anti-microbial (anti-fungal & anti-bacterial), anti-cancer,
antioxidant, anti-inflammatory, analgesics, anti-virus, and miscellaneous activities (listed in Table 1) exhibited
by potent oxo imidazoline derivatives. More than 50 scientific articles presenting more than 80 compounds
have been reviewed. Figures and tables provide the most pertinent data that have been carefully extracted and
organized.
Macrophage HERC6 Promotes NAFLD: Integrated Analyses of Mendelian Randomization and Single-Cell Transcriptome
Authors: Zou Shengyi , Du Xuan , Lu Wen , Shi Bimin
Published: January 2025

Aims and Objectives:

This study aimed to explore the relationship between HERC6-
associated immune response and Non-Alcoholic Fatty Liver Disease (NAFLD) and to screen
drug candidates for novel treatments.

Materials and Methods:

Mendelian Randomization (MR) was performed to test the relationship
between a genetically predicted increase in HERC6 expression and the development of NAFLD.
A single-cell RNA-seq profile of liver tissue with histological characteristics (GSE168933) was
obtained. The immune cell type with the highest HERC6 score was identified, and the HERC6
scores across hepatic steatosis, ballooning, and lobular inflammation were compared. Bulk RNA
data of liver samples from obese patients who underwent diet restriction or bariatric surgery
(GSE83452) was deconvoluted, and the proportions of distinct HERC6-high immune cell subpopulations
were estimated. The baseline and follow-up differences were compared to evaluate
the effectiveness of different therapies. Finally, a single-cell drug susceptibility assessment was
performed to screen drug candidates targeting HERC6-associated immune cells.

Results:

MR results showed that an increase in HERC6 expression was associated with an increase
in low-density lipoprotein cholesterol (LDL-C) level and the development of NAFLD.
The HERC6 score on monocyte-derived macrophage was the highest and positively correlated
with hepatic steatosis, ballooning, and lobular inflammation. The HERC6-high macrophage fraction
significantly decreased after bariatric surgery but not diet therapy. Triptolide was identified
as a potential drug for NAFLD targeting HERC6-high macrophages.

Conclusion:

The results highlighted the role of hepatic macrophage HERC6 in NAFLD