bluuebunny/crossref_metadata_2025 huggingface dataset:
In search for primary sources of placer diamonds of northeast Siberian craton: Evidence from the U–Pb ages and geochemistry of alluvial zircons
Authors: Nikolenko Evgeny I. , Agashev Aleksey M. , Tychkov Nikolay S. , Nikolenko Anna M. , Zhelonkin Roman Yu. , Ragozin Alexey L. , Afanasiev Valentin P. , Pokhilenko Nikolay P.
Published: August 2023

The northeastern Siberian craton stores numerous placers of diamonds that differ in morphology and texture, and originate from different types of primary deposits, primarily kimberlites. Analyses of mantle zircons selected from samples of alluvial and coarse clastic sediments in the watersheds of the Olenek and Kyutyungde rivers in the Anabar‐Olenek subprovince of the Yakutian diamond province provide constraints on kimberlite magmatism events in the area. The new U–Pb ages and typical kimberlitic signatures of the Kyutyungde zircons trace‐element patterns reveal three main magmatic events that produced kimberlites: Middle Paleozoic (Late Devonian to Early Carboniferous), Jurassic and Triassic. The Jurassic zircons (177–149 Ma) are mainly related to kimberlites in the proximal Kuoika‐Molodo and Khorbusuon fields. Triassic zircons (240–221 Ma) were probably released during large‐scale erosion of the eastern Anabar shield, however, the presence of such zircons in the Kyutyungde area indicates that kimberlites of the respective magmatic stage may exist within the immediate vicinity of the area. The only Middle Paleozoic zircon sample (358.6 Ma, D3‐C1 boundary) may originate from a proximal kimberlite within the Kyutyungde area. The presence of Middle Paleozoic kimberlitic zircons, along with harzburgite–dunitic pyropes, indicates that the primary deposit of diamonds and related minerals may exist near or within the Kyutyungde area. Late Ediacaran–Early Cambrian (573–473 Ma) mantle zircons found in Early Cambrian conglomerates of the area, along with other mantle minerals including Cr spinel of a diamond assemblage, record another Precambrian event of potentially diamondiferous magmatism in the Kyutyungde basin.
Relationship between Veterans Crisis Line risk rating and subsequent suicidal self‐directed violence among veteran callers: A gender comparison
Authors: Chhatre Sumedha , Hoffmire Claire A. , Bellamy Scarlett L. , Agha Aneeza Z. , Dichter Melissa E.
Published: August 2023

Background

Disparities in suicide rates by veteran status are particularly striking for women. Veterans Crisis Line (VCL) is a preventive strategy.

Objectives

Examine the relationships and gender differences between VCL risk rating, and subsequent suicidal self‐directed violence (SSDV) in the 12‐months following VCL index call.

Methods

Cohort study of VCL callers in 2018.

Outcomes

Dichotomized composite SSDV (non‐fatal suicide event and/or suicide) in the 12 months following VCL call.

Results

Veterans with high/moderate VCL risk had significantly higher odds of SSDV (OR = 4.02, 95% CI: 3.75, 4.30). There were no gender/VCL risk interaction (p = 0.3605). We also examined the association of gender, combination of VCL risk and suicide attempt (SA) history, on SSDV. Differential odds of SSDV for gender and combined VCL risk and SA history combinations were observed (p = 0.0005). Compared to those with lower VCL risk without SA history, those with high/moderate VCL risk with SA history showed higher odds of SSDV. Magnitude was higher for men, than for women veterans.

Conclusions and Relevance

Veterans Crisis Line risk assessment performs relatively stable across the gender binary and highlights potential gender differences when factoring in SA history. Combining risk assessment and attempt history may lead to effective suicide prevention strategies.
Escenas de miseria y desposesión: educación, beneficencia y valores burgueses en cuentos de Luisa Capetillo, Carmela Eulate y Ana Roqué
Authors: Stecher Guzmán Lucía
Published: August 2023

Este artículo analiza los cuentos “La vida real” (1893) de Carmela Eulate, “Sara la obrera” (1895) de Ana Roqué y “El cajero” (1916) de Luisa Capetillo. A partir de la consideración de las condiciones del contexto de producción —fundamentalmente el diagnóstico de crisis social y las propuestas de solución ofrecidas por distintos sectores—, se observa cómo estos relatos tematizan la pobreza de los sectores populares, las oportunidades que puede ofrecer la educación y sus relaciones con miembros de otras clases sociales. Mientras en los cuentos de Eulate y Roqué se expresa una preocupación por la perpetuación del orden social, en el de Capetillo se celebra su transgresión.
Convergence of Phase-Averaged, Transitional Flow in an Abdominal Aortic Aneurysmal Model
Authors: Kim Hyun Jin , Lee Chang Min , Rundfeldt Hans Christian , Lee Seungmin , Lee Inpyo , Jansen Kenneth
Published: August 2023

Abdominal aortic aneurysm can exhibit transitional flow characteristics in laminar flow regimes. To report transitional flow characteristics, we examined the convergence of phase-averaged solutions by executing blood flow simulations of a patient-specific abdominal aortic aneurysmal model for 257 cardiac cycles with periodic, pulsatile boundary conditions. The phase-averaged solutions were computed by averaging the solutions over various numbers of cardiac cycles and compared against the ones averaged over 124 cycles. The phase-averaged solutions reported small differences when they were averaged over a large number of cardiac cycles. The instantaneous solutions, however, failed to exhibit fluctuations reported in the phase-averaged solutions. To study transitional blood flows in the aneurysmal region, we need to report phase-averaged solutions as they exhibit nonperiodic, disturbed flow characteristics. Additionally, when reporting phase-averaged solutions, it is preferred to compute an average over a large number of cardiac cycles to be able to represent flow structures of the converged phase-averaged solutions.
Modeling, Feedforward Control, and Constrained Trajectory Generation for a Concrete Conveyance System
Authors: Blagojevic Boris , Gienger Andreas , Nigl David , Blandini Lucio , Sawodny Oliver
Published: August 2023

Automated fabrication of concrete elements requires precise control of outgoing volume flow. Since measurements of the volume flow or the total extruded volume are challenging during production, a feedforward control is required, which in turn necessitates a model of the dynamics at hand. In this paper, a concrete conveyance system with two pumps is considered. These are mounted at the inlet and outlet of the hose, respectively. Based on previous work, a dynamical model with concentrated parameters is derived, which is motivated on the general distributed dynamics of two-phase flow. The model is validated by experiments, with parameters calculated by a tailored estimation approach. Based thereon, a feedforward control approach is presented and tested in simulation, exploiting the approximate flatness of the system. The flat parametrization is then used for constrained, smooth setpoint transition of the volume flow with minimal transition time.
Photoemission spectroscopy on photoresist materials: A protocol for analysis of radiation sensitive materials
Authors: Sajjadian Faegheh S. , Galleni Laura , Dorney Kevin M. , Singh Dhirendra P. , Holzmeier Fabian , van Setten Michiel J. , Gendt Stefan De , Conard Thierry
Published: August 2023

The continued downscaling, following the so-called Moore's law, has motivated the development and use of extreme ultraviolet (EUV) lithography scanners with specialized photoresists. Since the quality and precision of the transferred circuit pattern are determined by the EUV-induced chemical changes in the photoresist, having a deep understanding of these chemical changes is of pivotal importance. For this purpose, several spectroscopic and material characterization techniques have already been employed. Among them, photoemission can be essential as it not only allows direct probing of chemical bonds in a quantitative way but also provides useful information regarding the generation and distribution of primary and secondary electrons. However, since high energy photons are being employed for characterization of a photosensitive material, modification of the sample during the measurement is possible, and this must be considered when investigating the chemical changes in the photoresist before and after exposure to EUV light. In this paper, we investigate the chemical changes occurring during the photoemission measurements of an unexposed, model chemically amplified resist based on the well-known environmentally stable chemically amplified photoresist as a function of a number of measurement parameters, using both an x ray (AlKα, 1486.6 eV) and a UV source (HeII, 40.8 eV). We will show that these chemical changes can be simulated through theoretical modeling of the photoemission spectra. Based on these results, we propose a measurement protocol allowing to minimize or eliminate this modification which will help to guide (or enable) photoemission measurements on radiation-sensitive materials (e.g., photoresists).
Numerical simulations of musical instruments
Authors: Giordano Nicholas
Published: August 2023

The Reflections series takes a look back on historical articles from The Journal of the Acoustical Society of America that have had a significant impact on the science and practice of acoustics.
Passive directivity detection of acoustic sources based on acoustic Luneburg lens
Authors: Zhao Liuxian , Tang Lihua , Liu Yuxin , Sun Zhaoyong , Liu Qimin , Bi Chuanxing
Published: August 2023

This article reports an acoustic Luneburg lens (ALL) design with graded refractive index for passive directivity detection of acoustic sources. The refractive index profile of the lens is realized based on square pillars with graded variation of their dimensions. Numerical and experimental studies are conducted to investigate the performance of directivity detection. The results demonstrate that the lens designed and developed in this study is capable of precisely detecting the directivity of one acoustic source. Furthermore, the directivities of two acoustic sources can also be detected with a resolution of 15°. In addition, different methods are investigated, including introducing phase difference by tuning input signals or moving ALL, and increasing the aperture size of ALL, to improve the resolution of dual sources directivity detection.
One Nation, One Team: The U.S. Women’s National Team’s Equal Pay Victory and Its Broader Impact
Authors: Pincus Ben , Brown Martha , Lopes Alexia
Published: August 2023

This teaching-based case study focuses on and addresses issues and opportunities in women’s sports. The context used for such discussions are the U.S. Women’s National Soccer team’s accomplishments (e.g., mainly the settlement for equal pay). Both the main case and the teaching materials enlighten examinations in three principal areas (i.e., leadership, diversity, and marketing). As future leaders in the sports industry, we believe that Sport Management students should be prompted to discuss issues and opportunities beyond what we have long referred to as (traditional) “sports,” to intentionally focus on and address issues and opportunities in women’s sports. Nonetheless, the benefits of the present case study reside in its ability to invite students to consider topics and current events in sports that are imperative to continue the momentum to move sports (in particular, women sports) forward. This teaching-based case study is intended for third- or fourth-year undergraduate students. Given its broad approach and focus in three different areas (i.e., leadership, diversity, and marketing), the case could be used in several sport courses, such as management or business of sports, sport marketing, sport diversity, sport sociology, or sport leadership. Knowledge is gained via individual and teamwork, class debates, and written assignments.
Bacteriophage populations mirror those of bacterial pathogens at sites of infection
Authors: Haddock N. L. , Barkal L. J. , Bollyky P. L.
Published: August 2023

Bacteriophages, viruses that parasitize bacteria, are known to be abundant at sites of bacterial colonization, but the relationship between phages and bacteria at sites of infection is unclear. Bacteriophages are highly specific to their bacterial host species, and so we hypothesize that phage populations would mirror those of bacterial pathogens within infected tissues. To test this, here we study publicly available cell-free DNA (cfDNA) generated using next-generation sequencing of infected bodily fluids, including urine, joint fluid, peritoneal fluid, bronchoalveolar lavage fluid, cerebrospinal fluid, and abscess fluid, as well as uninfected control samples. These were analyzed using a computational pipeline for identifying bacteriophage sequences in cfDNA. We find that bacteriophage sequences are present in both infected and uninfected bodily fluids and represent a variety of bacteriophage morphologies and bacterial hosts. Additionally, phages from
Escherichia coli
,
Streptococcus
, and
Staphylococcus aureus
are overrepresented both in terms of proportion and diversity in fluids infected with these same pathogens. These data indicate that phages reflect the relative abundance of their bacterial hosts at sites of infection. Bacteriophage sequences may help inform future investigative and diagnostic approaches that utilize cell-free DNA to study the microbiome within infected tissues.

IMPORTANCE

Bacteriophages are an active area of investigation in microbiome research, but most studies have focused on phage populations at sites of bacterial colonization. Little is known about bacteriophage ecology at sites of active infection. To address this gap in knowledge, we utilized a publicly available data set to study bacteriophage populations in cell-free DNA collected from sites of infection. We find that phages reflect the relative abundance of their bacterial hosts at sites of infection. These studies may lead to future investigative and diagnostic approaches that incorporate phages as well as bacterial cell-free DNA.
Supplemental Material: Development of a back-arc basin from initial rifting to seafloor spreading: Constraints from Paleozoic basic rocks in the North Qinling accretionary orogen, central China
Authors: Chang Huan , Wu Yuan-Bao , al. et
Published: August 2023

Figures S1–S6. Table S1: Zircon U-Pb isotopic data obtained by SIMS for samples 16QL87 and 16QL89 from the mafic dikes of the Qinling orogen. Table S2: Major (in wt%) and trace element (in ppm) contents of the mafic dike samples and international and Chinese standards. Table S3: Whole-rock Sr-Nd-Hf isotope compositions of the mafic dike samples (t = 453 Ma). Table S4: Zircon Hf and O isotopic data obtained by LA-MC-ICPMS and SIMS for samples 16QL87 and 16QL89, respectively. 
Giant Spatial Redistribution of Electrons in a Wide Quantum Well Induced by Quantizing Magnetic Field
Authors: Dorozhkin S. I. , Kapustin A. A. , Fedorov I. B. , Umansky V. , Smet J. H.
Published: August 2023

In samples of field-effect transistors based on GaAs/AlGaAs heterostructures with an electron system in a single 50-nm-wide GaAs quantum well, a transition stimulated by a quantizing magnetic field has been detected from a bilayer state of the system in zero magnetic field to a single-layer state when only the lowest Landau level is filled. In contrast to the results for the 60-nm-wide quantum well obtained in [S. I. Dorozhkin, A. A. Kapustin, I. V. Fedorov, V. Umansky, and J. H. Smet, Phys. Rev. V 102, 235307 (2020)], the single-layer state is observed not only in incompressible quantum Hall effect states of the electron system at filling factors of 1 and 2, but also in compressible states between these filling factors. The spatial location of the single-layer system in the quantum well has been established; it appears to be independent of the electron distribution over the layers in a low magnetic field. A possible qualitative explanation for this observation has been proposed. The detected transition is supposedly due to the negative compressibility of two-dimensional electron systems caused by exchange-correlation contributions to the electron−electron interaction.
Prediction of knee joint pain in Tai Chi practitioners: a cross-sectional machine learning approach
Authors: Xing Hua , Su Xiaojie , Liu Yushan , Chen Yang , Ju Yubin , Kang Zhiran , Sun Wuquan , Yao Fei , Yao Lijun , Gong Li
Published: August 2023

Objective

To build a supervised machine learning-based classifier, which can accurately predict whether Tai Chi practitioners may experience knee pain after years of exercise.

Design

A prospective approach was used. Data were collected using face-to-face through a self-designed questionnaire.

Setting

Single centre in Shanghai, China.

Participants

A total of 1750 Tai Chi practitioners with a course of Tai Chi exercise over 5 years were randomly selected.

Measures

All participants were measured by a questionnaire survey including personal information, Tai Chi exercise pattern and Irrgang Knee Outcome Survey Activities of Daily Living Scale. The validity of the questionnaire was analysed by logical analysis and test, and the reliability of this questionnaire was mainly tested by a re-test method. Dataset 1 was established by whether the participant had knee pain, and dataset 2 by whether the participant’s knee pain affected daily living function. Then both datasets were randomly assigned to a training and validating dataset and a test dataset in a ratio of 7:3. Six machine learning algorithms were selected and trained by our dataset. The area under the receiver operating characteristic curve was used to evaluate the performance of the trained models, which determined the best prediction model.

Results

A total of 1703 practitioners completed the questionnaire and 47 were eliminated for lack of information. The total reliability of the scale is 0.94 and the KMO (Kaiser-Meyer-Olkin measure of sampling adequacy) value of the scale validity was 0.949 (>0.7). The CatBoost algorithm-based machine-learning model achieved the best predictive performance in distinguishing practitioners with different degrees of knee pain after Tai Chi practice. ‘Having knee pain before Tai Chi practice’, ‘knee joint warm-up’ and ‘duration of each exercise’ are the top three factors associated with pain after Tai Chi exercise in the model. ‘Having knee pain before Tai Chi practice’, ‘Having Instructor’ and ‘Duration of each exercise’ were most relevant to whether pain interfered with daily life in the model.

Conclusion

CatBoost-based machine learning classifier accurately predicts knee pain symptoms after practicing Tai Chi. This study provides an essential reference for practicing Tai Chi scientifically to avoid knee pain.
Qualitative exploration of the impact of COVID-19 on the food environment of urban informal settlements of Dhaka, Bangladesh
Authors: Hasan A M Rumayan , Smith George , Selim Mohammad Abdus , Khatun Fatema , Mahmood Shehrin Shaila , Reidpath Daniel D , Rasheed Sabrina
Published: August 2023

Objective

Our study explored the impact of the COVID-19 pandemic on the food environment from the perspective of the urban poor and food vendors.

Design

This was a qualitative study conducted during September 2020 and February 2021.

Setting

The study was carried out in two purposively selected informal settlements of Dhaka City, Bangladesh.

Participants

We conducted 21 in-depth interviews with residents of informal settlements and 10 key informant interviews with food vendors and food aid workers.

Result

The availability of staple foods was not disrupted during the pandemic but some perishables foods became more expensive due to supply chain disruptions and increased transportation costs. Limited market hours affected market access and mobility restrictions adversely affected local vendors. Cart vendors selling perishables incurred business losses they could ill afford. Demand for food reduced as employment disruption lead to reduced purchasing power and, therefore, reduction of quantity, quality and desirability of foods purchased. Respondents reported skipping meals and going hungry. The aid received was considered inadequate to meet needs.

Conclusion

The food environment of the urban poor was disrupted from both supply and demand sides and the organisational response (both government and non-government) was severely inadequate. The social safety net needs to be extended and redesigned to ensure food security and health for the urban working poor in the future.
Effect of price and income on the demand for sugar-sweetened beverages in Nigeria: an analysis of household consumption data using an almost ideal demand system (AIDS)
Authors: Darsamo Vanessa , Walbeek Corne
Published: August 2023

Objectives

To estimate the own-price, cross-price and income elasticities for carbonated soft drinks (CSDs), malt drinks, chocolate powder, sachet water and sugar in Nigeria. These elasticities can be used to estimate the potential demand response to the recently-introduced sugar tax in Nigeria.

Setting

The study uses household data from the 2018/2019 Nigeria Living Standards Survey (NLSS).

Participants

The NLSS is a national household survey. 21 114 households were included in the final sample for this analysis.

Primary and secondary outcomes

We used Deaton’s almost ideal demand system, which controls for the goods’ quality, to estimate the effect of price and income changes on the demand for CSDs, chocolate powder, malt drinks, sachet water and sugar.

Results

We found that the own-price elasticity (ordered from most to least price-responsive) was −0.99 (p<0.01) for sachet water, −0.76 (p<0.01) for CSDs, –0.72 (p<0.01) for chocolate powder, −0.62 (p<0.01) for sugar and –0.19 (p<0.01) for malt drinks. The cross-price elasticities indicate that malt drinks and chocolate powders are substitutes of CSDs. The income elasticities indicate that all the commodities are normal goods. Sachet water had the highest income elasticity at 0.62 (p<0.01), followed by chocolate powder at 0.54 (p<0.01), CSDs at 0.47 (p<0.01), malt drinks at 0.43 (p<0.01) and sugar at 0.13 (p<0.01).

Conclusion

Even though the price elasticities for CSDs, malt drinks and chocolate powder are less than one, in absolute terms, they are significantly different from zero. Increases in the sugar-sweetened beverage tax could curb the demand for these beverages, and, in turn, reduce the incidence and prevalence of sugar-attributable diseases.
Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions
Authors: Alex Karla , Winkler Eva C
Published: August 2023

Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III).
A novel intrasaccular aneurysm device with high complete occlusion rate: initial results in a rabbit model
Authors: Zoppo Christopher T , Kolstad Josephine W , King Robert M , Wolfe Thomas , Kraitem Afif , Vardar Zeynep , Badruddin Aamir , Pereira Edgard , Guerrero Boris Pabón , Rosqueta Arturo S , Ughi Giovanni J , Gounis Matthew J , Zaidat Osama O , Anagnostakou Vania
Published: August 2023

Background

Intrasaccular flow-disrupting devices are a safe and effective treatment strategy for intracranial aneurysms. We utilized high-frequency optical coherence tomography (HF-OCT) and digital subtraction angiography (DSA) to evaluate SEAL Arc, a new intrasaccular device, and compare the findings with the well-established Woven EndoBridge (WEB) device in an animal model of saccular aneurysms.

Methods

In a rabbit model, elastase-induced aneurysms were treated with SEAL Arc (n=11) devices. HF-OCT and DSA were performed after implant and repeated after 12 weeks. Device protrusion and malapposition were assessed at implant time and scored on a binary system. Aneurysm occlusion was assessed at 12 weeks with the WEB Occlusion Scale and dichotomized to complete (A and B) or incomplete (C and D) occlusion. The percentage of neointimal coverage after 12 weeks was quantified using HF-OCT. We compared these data to previously published historical controls treated with the gold-standard WEB device (n=24) in the same model.

Results

Aneurysm size and device placement were not significantly different between the two groups. Complete occlusion was demonstrated in 80% of the SEAL Arc devices, which compared favorably to the 21% of the aneurysms treated with WEB devices (P=0.002). Neointimal coverage across SEAL Arc devices was 86±15% compared with 49±27% for WEB (P=0.001). Protruding devices had significantly less neointimal coverage (P<0.001) as did incompletely occluded aneurysms (P<0.001). Histologically, all aneurysms treated with SEAL Arc devices were completely healed.

Conclusion

Complete early aneurysm occlusion was frequently observed in the SEAL Arc treated aneurysms, with significant neointimal coverage after 12 weeks.
Field observed GCL panel shrinkage for five GCLs in composite liners
Authors: Rentz A.K. , Brachman R.W.I. , Rowe R.K. , Take W.A.
Published: August 2023

Field observed shrinkage was quantified and compared for one geosynthetic clay liner (GCL) type left covered only by a black geomembrane, a white geomembrane, and 0.3 m of gravel cover. Shrinkage is reported for up to 28 months field exposure of an additional four GCLs beneath a black geomembrane. All GCLs were needle-punched geotextile encased: one containing fine granular bentonite, two with powdered bentonite, one with polymer amended granular bentonite, and one multicomponent GCL with a film coating installed film up. All the GCLs examined have the potential to shrink with the magnitude of the shrinkage primarily dependent on the thermal/moisture cycles to which it is subjected and the degree of adhesion between panel overlaps. It is shown that the panel overlap adhesion can be highly variable and this is primarily attributed to condensation of water vapour below geomembrane wrinkles during daily thermal cycles. With a an initial GCL overlap of 300 mm, the shrinkage observed over 28 months left ≥32% of the original overlap; however, if the overlap had been only 150 mm, then gaps or ineffective seams would have occurred for several GCLs. Guidance regarding mitigating GCL panel shrinkage is provided.
Study on Phosphorus Adsorption Performance of Inorganic Modified Green Mudstone
Authors: Li Liang , Shi Ke , Xiong Shaojun , Zhang Shimeng , Shan Zhuang , Qian Guangsheng , Zhai Xu , Xiao Ping
Published: August 2023

Inorganic modified green mudstone (MGM) was prepared from the green mudstone (GM) residue of Fushun West Open Pit Mine and characterized by XRF, XRD, FTIR, and SEM of GM and MGM. According to the calculation of pore size and the BET equation, the pore size and specific surface area of the MGM were larger. The results of adsorption kinetics and isothermal adsorption experiments showed that the adsorption capacity of MGM for phosphate increased from 0.1 mg/g to 0.71 mg/g, which was obviously better than that of GM. The GM and MGM accorded with the quasi-second-order kinetic model. The isothermal adsorption data of GM accorded with the Freundlich model, and the isothermal data of MGM accorded with the Langmuir model, which indicated that the model of GM and MGM was an adsorption process from a double layer to a single layer. Thermodynamic data showed that the increase in temperature was beneficial to the adsorption of MGM. The internal diffusion model showed that due to the change of pore size structure after modification, the number of adsorption sites that could provide phosphate was increased, and at the same time, the change of internal elements led to the extension of the chemical reaction time by 700 min. Because of the ligand exchange and electrostatic interaction between phosphate, GM, and MGM, the adsorption results showed that acidity was better than alkalinity. To improve the recycling ability of MGM, hydrochloric acid with a concentration of 0.1 mol/L was determined as the best phosphorus resolving agent, and the resolving rate was still close to 80% after five cycles. The results showed that the MGM could be a promising adsorbent for the removal of phosphorus, providing a new way for resource utilization of mining waste residue.
Investigating Fatigue and Its Relationship to Quality of Life and Pruritus in Cutaneous T-Cell Lymphoma
Authors: Özistanbullu Deniz , Hackenberg Stephan , Kleemann Johannes , Kippenberger Stefan , Lenders Daniela , Tratzmiller Sabine , Kaufmann Roland , Klemke Claus-Detlev , Meissner Markus , Jäger Manuel
Published: August 2023

Cancer-related fatigue as a morbid state of physical, emotional, and mental exhaustion influencing everyday life is an important yet poorly investigated symptom in patients with cutaneous T-cell lymphomas. The aim of this study was to evaluate the prevalence of and the association between pruritus, quality of life, and fatigue in patients with cutaneous T-cell lymphomas. Mycosis fungoides and Sézary syndrome patients were invited to complete the Functional Assessment of Cancer Therapy-General (FACT-G) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) subscale questionnaire. Pruritus was assessed using the peak pruritus numeric rating scale. Half of the 38 recruited patients reported fatigue. 13 patients (34%) suffered from severe fatigue. The median (interquartile range) FACIT-Fatigue subscale score was 35.5 (25.75–43). The advanced disease stage was associated with more severe fatigue and a poorer quality of life. The FACIT-Fatigue subscale score was significantly correlated with quality of life (r = 0.8 and

P

 < 0.0001). More than 80% of patients reported pruritus. There was no correlation between pruritus and fatigue (r = −0.19 and

P

 = 0.26). All in all, fatigue is a common symptom of cutaneous T-cell lymphomas in early and advanced stage disease and has a strongly negative effect on cutaneous T-cell lymphoma patients’ quality of life.
A Novel Pathogen of an Emerging Infectious Disease (Large Kidney Disease) in Farmed Blue Foxes
Authors: Wang Yumao , Gu Chenchen , Han Qiang , Fu Shijun , Wang Jianjun , Zhuang Jinqiu , Guo Guangjun , Liu Jinfeng , Yu Xinyou , Qu Guanggang , Shen Zhiqiang
Published: August 2023

An emerging infectious disease (EID) in foxes called “large kidney disease”, characterized by enlarged kidneys, has been breaking out in fox farms in China, although its pathogenesis has not yet been elucidated. Here, we performed viral metagenomics sequencing on diseased fox tissue samples that identified a virus with 82.6% homology to the xenotropic murine leukemia virus-related virus (XMRV) PreXMRV-1 provirus strain (GenBank accession number NC_007815.2) in sick fox tissue. It was named PreXMRV-20, and its genome was verified by reverse transcription-polymerase chain reaction (PCR) and PCR product sequencing. Nonenveloped and polygonal virus-like particles consistent with the shape and size of XMRV were observed by negative staining electron microscopy. Administered subcutaneously, PreXMRV-20 infected weaned foxes, leading to growth retardation. The discovery of the PreXMRV-20 strain (the first isolation of an XMRV homolog in blue foxes) identifies a potential public health issue in blue fox breeding since XMRV has been confirmed to be a zoonotic virus.
Betalain-Enriched Beetroots Exhibit Antiulcer and Anti-inflammatory Potentials
Authors: Saad Fatma , Al-Shaikh Turki M. , Zouidi Ferjeni , Taher Mostafa A. , Saidi Saber Abdelkader , Hamden Khaled
Published: August 2023

Introduction. Recently, plant natural food colorants have received a growing interest due to their therapeutic and preventive activities against various diseases. This study is aimed at evaluating the phytochemical composition by high-performance liquid chromatography with diode array detection (HPLC-DAD) and at evaluating the antiulcer effect of red beetroot betalains (BRB). Materials and Methods. Ethanol was used for gastric mucosa damage, ulcer, and inflammation induction in rat. Results. HPLC-DAD data revealed the existence of numerous compounds, including betanidin 5-glucoside (43.22%), isobetanidin 5-glucoside (18.47%), 2,17-bidecarboxy-neobetanin (7.07%), 2-O-glucosyl-betanin (4.03%), 17-decarboxy-betanidin (3.61%), neobetanin (3.24%), and eight other compounds whose yields were too low. In vitro as in gastric tissues in rats, BRB potentially inhibited key enzymes—relation to gastric ulceration and damage as pepsin, lipoxygenase, and hyaluronidase activities. In ethanol-induced gastric ulcer and inflammation, BRB administration at doses 200, 400, and 800 mg/kg significantly (

p
≤
0.05

) decreases the ulcer areas (UA) and index (UI); increases the curative index (CI) by 78.1, 78.4, and 78%, respectively; and ameliorates the pathological damage induced by ethanol. In addition, BRB administration to rat gastric ulcer rats prevented significantly (

p
≤
0.05

) the decrease of gastric mucus (GM) content (by 116%) and reduced the stress oxidant, evidenced by a significant (

p
≤
0.05

) decrease of gastric mucosa thiobarbituric acid reactive species (TBARS) (by 28%) and mucus juice pepsin by 56%. Conclusion. Taken together, BRB exerted potential therapeutic efficacy for gastric ulceration.
Table S2 from Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold
Authors: Griessinger Emmanuel , Pereira-Martins Diego , Nebout Marielle , Bosc Claudie , Saland Estelle , Boet Emiline , Sahal Ambrine , Chiche Johanna , Debayle Delphine , Fleuriot Lucile , Pruis Maurien , De Mas Véronique , Vergez François , Récher Christian , Huls Gerwin , Sarry Jean-Emmanuel , Schuringa Jan Jacob , Peyron Jean-François
Published: August 2023

Proteomic_list_Pearson_Q1V-time
Table S8 from Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer
Authors: Müller Nina , Lorenz Carina , Ostendorp Jenny , Heisel Felix S. , Friese Ulrich P. , Cartolano Maria , Plenker Dennis , Tumbrink Hannah , Heimsoeth Alena , Baedeker Philipp , Weiss Jonathan , Ortiz-Cuaran Sandra , Büttner Reinhard , Peifer Martin , Thomas Roman K. , Sos Martin L. , Berg Johannes , Brägelmann Johannes
Published: August 2023

Suppl. Table S8, candidates from CRISPR activation screen
Supplementary Data from Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer
Authors: Müller Nina , Lorenz Carina , Ostendorp Jenny , Heisel Felix S. , Friese Ulrich P. , Cartolano Maria , Plenker Dennis , Tumbrink Hannah , Heimsoeth Alena , Baedeker Philipp , Weiss Jonathan , Ortiz-Cuaran Sandra , Büttner Reinhard , Peifer Martin , Thomas Roman K. , Sos Martin L. , Berg Johannes , Brägelmann Johannes
Published: August 2023

Supplementary Methods, Figures and Tables
Supplementary Data from Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer
Authors: Müller Nina , Lorenz Carina , Ostendorp Jenny , Heisel Felix S. , Friese Ulrich P. , Cartolano Maria , Plenker Dennis , Tumbrink Hannah , Heimsoeth Alena , Baedeker Philipp , Weiss Jonathan , Ortiz-Cuaran Sandra , Büttner Reinhard , Peifer Martin , Thomas Roman K. , Sos Martin L. , Berg Johannes , Brägelmann Johannes
Published: August 2023

Supplementary Note covering the mathematical modelling
Supplemental Figure Legends from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Legends for Supplemental Figures S1-S9
Figure S5 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 5
Supplementary File 8 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
Authors: Ludwig Michael P. , Galbraith Matthew D. , Eduthan Neetha Paul , Hill Amanda A. , Clay Michael R. , Tellez Cristiam Moreno , Wilky Breelyn A. , Elias Anthony , Espinosa Joaquin M. , Sullivan Kelly D.
Published: August 2023

Agarose gels.
Supplementary File 7 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
Authors: Ludwig Michael P. , Galbraith Matthew D. , Eduthan Neetha Paul , Hill Amanda A. , Clay Michael R. , Tellez Cristiam Moreno , Wilky Breelyn A. , Elias Anthony , Espinosa Joaquin M. , Sullivan Kelly D.
Published: August 2023

Western blots.
Figure S1 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 1
Table 2 from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
Authors: Aglago Elom K. , Kim Andre , Lin Yi , Qu Conghui , Evangelou Marina , Ren Yu , Morrison John , Albanes Demetrius , Arndt Volker , Barry Elizabeth L. , Baurley James W. , Berndt Sonja I. , Bien Stephanie A. , Bishop D. Timothy , Bouras Emmanouil , Brenner Hermann , Buchanan Daniel D. , Budiarto Arif , Carreras-Torres Robert , Casey Graham , Cenggoro Tjeng Wawan , Chan Andrew T. , Chang-Claude Jenny , Chen Xuechen , Conti David V. , Devall Matthew , Diez-Obrero Virginia , Dimou Niki , Drew David , Figueiredo Jane C. , Gallinger Steven , Giles Graham G. , Gruber Stephen B. , Gsur Andrea , Gunter Marc J. , Hampel Heather , Harlid Sophia , Hidaka Akihisa , Harrison Tabitha A. , Hoffmeister Michael , Huyghe Jeroen R. , Jenkins Mark A. , Jordahl Kristina , Joshi Amit D. , Kawaguchi Eric S. , Keku Temitope O. , Kundaje Anshul , Larsson Susanna C. , Marchand Loic Le , Lewinger Juan Pablo , Li Li , Lynch Brigid M. , Mahesworo Bharuno , Mandic Marko , Obón-Santacana Mireia , Moreno Victor , Murphy Neil , Nan Hongmei , Nassir Rami , Newcomb Polly A. , Ogino Shuji , Ose Jennifer , Pai Rish K. , Palmer Julie R. , Papadimitriou Nikos , Pardamean Bens , Peoples Anita R. , Platz Elizabeth A. , Potter John D. , Prentice Ross L. , Rennert Gad , Ruiz-Narvaez Edward , Sakoda Lori C. , Scacheri Peter C. , Schmit Stephanie L. , Schoen Robert E. , Shcherbina Anna , Slattery Martha L. , Stern Mariana C. , Su Yu-Ru , Tangen Catherine M. , Thibodeau Stephen N. , Thomas Duncan C. , Tian Yu , Ulrich Cornelia M. , van Duijnhoven Franzel JB , Van Guelpen Bethany , Visvanathan Kala , Vodicka Pavel , Wang Jun , White Emily , Wolk Alicja , Woods Michael O. , Wu Anna H. , Zemlianskaia Natalia , Hsu Li , Gauderman W. James , Peters Ulrike , Tsilidis Konstantinos K. , Campbell Peter T.
Published: August 2023

Summary of G × BMI analyses using 1DF, two-step, and 3DF analyses.
Supplementary File 3 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
Authors: Ludwig Michael P. , Galbraith Matthew D. , Eduthan Neetha Paul , Hill Amanda A. , Clay Michael R. , Tellez Cristiam Moreno , Wilky Breelyn A. , Elias Anthony , Espinosa Joaquin M. , Sullivan Kelly D.
Published: August 2023

GSEA of nutlin-3-treated LPS transcriptome data.
Supplementary Table S4 from Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Authors: Cui Wei , Huang Zhijun , Jin Seung-Gi , Johnson Jennifer , Lau Kin H. , Hostetter Galen , Pfeifer Gerd P.
Published: August 2023

Differential gene expression analysis
Supplementary Table S3 from Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Authors: Cui Wei , Huang Zhijun , Jin Seung-Gi , Johnson Jennifer , Lau Kin H. , Hostetter Galen , Pfeifer Gerd P.
Published: August 2023

ChIP-seq peaks
Supplementary Tables from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Tables
Supplementary Materials and Methods from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Materials and Methods
Supplementary Figure 5 from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Figure 5
Supplementary Figure 4 from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Figure 4
Supplementary Figure 3 from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Figure 3
Supplementary Materials, Figure S1-S4, Table S1-S9 from Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C
Authors: Hu Chunling , Nagaraj Anil Belur , Shimelis Hermela , Montalban Gemma , Lee Kun Y. , Huang Huaizhi , Lumby Carolyn A. , Na Jie , Susswein Lisa R. , Roberts Maegan E. , Marshall Megan L. , Hiraki Susan , LaDuca Holly , Chao Elizabeth , Yussuf Amal , Pesaran Tina , Neuhausen Susan L. , Haiman Christopher A. , Kraft Peter , Lindstrom Sara , Palmer Julie R. , Teras Lauren R. , Vachon Celine M. , Yao Song , Ong Irene , Nathanson Katherine L. , Weitzel Jeffrey N. , Boddicker Nicholas , Gnanaolivu Rohan , Polley Eric C. , Mer Georges , Cui Gaofeng , Karam Rachid , Richardson Marcy E. , Domchek Susan M. , Yadav Siddhartha , Hruska Kathleen S. , Dolinsky Jill , Weroha S. John , Hart Steven N. , Simard Jacques , Masson Jean Yves , Pang Yuan-Ping , Couch Fergus J.
Published: August 2023

Supplementary Materials, References, Tables and Figures
Supplementary figure legends from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Authors: Shu Xiaodong , Li Jianjie , Chan Un In , Su Sek Man , Shi Changxiang , Zhang Xin , An Tingting , Xu Jun , Mo Lihua , Liu Jianlin , Wang Yuqing , Li Xiaoling , Deng Min , Lei Josh Haipeng , Wang Chunfei , Tian Hao , Heng Sun , Shim Joong Sup , Zhang Xuanjun , Dai Yunlu , Yao Zhicheng , Kuang Xiaying , Lin Ying , Deng Chu-Xia , Xu Xiaoling
Published: August 2023

supp. figure legends S1-S7
Figure S6 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Authors: Shu Xiaodong , Li Jianjie , Chan Un In , Su Sek Man , Shi Changxiang , Zhang Xin , An Tingting , Xu Jun , Mo Lihua , Liu Jianlin , Wang Yuqing , Li Xiaoling , Deng Min , Lei Josh Haipeng , Wang Chunfei , Tian Hao , Heng Sun , Shim Joong Sup , Zhang Xuanjun , Dai Yunlu , Yao Zhicheng , Kuang Xiaying , Lin Ying , Deng Chu-Xia , Xu Xiaoling
Published: August 2023

Original picture
Supplementary Data from PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING–Type I Interferon Signaling in Glioblastoma
Authors: Mondal Isha , Das Oishika , Sun Raymond , Gao Jian , Yu Bohyeon , Diaz Aaron , Behnan Jinan , Dubey Abhishek , Meng Zhipeng , Eskandar Emad , Xu Beisi , Lu Rongze Olivia , Ho Winson S.
Published: August 2023

Supplementary Text Figs. S1 to S8 Tables S1 to S3
Figure S4 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Authors: Shu Xiaodong , Li Jianjie , Chan Un In , Su Sek Man , Shi Changxiang , Zhang Xin , An Tingting , Xu Jun , Mo Lihua , Liu Jianlin , Wang Yuqing , Li Xiaoling , Deng Min , Lei Josh Haipeng , Wang Chunfei , Tian Hao , Heng Sun , Shim Joong Sup , Zhang Xuanjun , Dai Yunlu , Yao Zhicheng , Kuang Xiaying , Lin Ying , Deng Chu-Xia , Xu Xiaoling
Published: August 2023

Original picture