Beyond Target Chemicals: Updating the NORMAN Prioritisation Scheme to Support the EU Chemical Strategy with Semi-quantitative Suspect/Non-target Screening Data
Authors: Dulio Valeria , Alygizakis Nikiforos , Ng Kelsey , Schymanski Emma L. , Andres Sandrine , Vorkamp Katrin , Hollender Juliane , Finckh Saskia , Aalizadeh Reza , Ahrens Lutz , Bouhoulle Elodie , Čirka Ľuboš , Derksen Anja , Deviller Geneviève , Duffek Anja , Esperanza Mar , Fischer Stellan , Fu Qiuguo , Gago-Ferrero Pablo , Haglund Peter , Junghans Marion , Kools Stefan A.E. , Koschorreck Jan , Lopez Benjamin , Alda Miren Lopez , Mascolo Giuseppe , Miège Cécile , Osté Leonard , O’Toole Simon , Rostkowski Pawel , Schulze Tobias , Sims Kerry , Six Laetitia , Slobodnik Jaroslav , Staub Pierre-François , Stroomberg Gerard , Togola Anne , Tomasi Giorgio , Ohe Peter C. 
Published: March 2024

Background: Prioritisation of chemical pollutants is a major challenge for environmental managers and decision-makers alike, which is essential to help focus the limited resources available for monitoring and mitigation actions on the most relevant chemicals. This study extends the original NORMAN prioritisation scheme beyond target chemicals, presenting the integration of semi-quantitative data from retrospective suspect screening and expansion of existing exposure and risk indicators. The scheme utilises data retrieved automatically from the NORMAN Database System (NDS), including candidate compounds for prioritisation, target and suspect screening data, ecotoxicological effect data, physico-chemical data and other properties. Two complementary workflows using target and suspect screening monitoring data are applied to first group the substances into six action categories and then rank the compounds using exposure, hazard and risk indicators. The results from the ‘target’ and ‘suspect screening’ workflows can then be combined as multiple lines of evidence to support decision-making on regulatory and research actions.
Results: As a proof-of-concept, the new scheme was applied to a combined dataset of target and suspect screening data. To this end, 65,690 compounds on the NDS, of which 2,579 substances supported by target wastewater monitoring data, were retrospectively screened in 84 effluent wastewater samples, totalling >11 million data points. The final prioritisation results identified 577 compounds as high priority for further actions, 45,462 as medium priority and 308 with potentially lower priority for actions, while it was not possible to conclude for 18,000 compounds due to insufficient information from target monitoring and uncertainty in the identification from suspect screening. A high degree of agreement was observed between the categories assigned via target analysis and suspect screening-based prioritisation. Suspect screening was a valuable complementary approach to target analysis, helping to prioritise thousands of compounds that are insufficiently investigated in current monitoring programmes.
Conclusions: This updated prioritisation workflow responds to the increasing use of suspect screening techniques. It can be adapted to different environmental compartments and can support regulatory obligations, including the identification of specific pollutants in river basins and the marine environments, as well as the confirmation of environmental occurrence levels predicted by modelling tools.