bluuebunny/crossref_metadata_2025 huggingface dataset:
Microdeletion 11q13.1.q13.2 in a patient presenting with developmental delay, facial dysmorphism, and esophageal atresia: Possible role of the GSTP1 gene in esophagus malformation
Authors: Ferreira de Almeida Tatiana , Bertola Débora Romeo
Published: July 2013

BACKGROUND: Esophageal atresia is a major congenital malformation characterized by a complete interruption of the esophageal continuity. It is frequently observed in associations and syndromes. As an isolated finding, it has a multifactorial etiology whose genetic factors are poorly known. Recently, the GST family, especially the GSTM1 null genotype (but not the GSTP1 polymorphism I105V), has been associated with esophageal atresia. These enzymes play a role in phase II detoxification of xenobiotics. Here we present the clinical and molecular findings observed in a patient suggesting that the loss of the GSTP1 allele might predispose to this malformation. CASE: We describe a patient presenting with esophageal atresia associated with developmental delay and facial dysmorphism, whose mother used tobacco and alcohol during the first 2 months of her pregnancy. Microdeletion/microduplication analysis was performed using comparative genomic hybridization and a 180K Agilent array. It detected a de novo 2 Mb chromosome 11q13.1.q13.2 deletion. CONCLUSION: The deleted chromosomal segment includes the GSTP1 gene. We hypothesize that the deletion of one GSTP1 allele (an isoform highly expressed in embryonic tissues), associated with specific environmental factors, such as tobacco and alcohol, could cause the esophageal atresia observed in our patient. Birth Defects Research (Part A) 97:463–466, 2013. © 2013 Wiley Periodicals, Inc.
Insights into the Evaporation Kinetics of Indomethacin Solutions
Authors: Hellstén S. , Han B. , Mäkilä E. , Niemi H. , Salonen J. , Lehto V.‐P. , Stelzer T. , Louhi‐Kultanen M. , Ulrich J.
Published: July 2013

Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100 °C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.
Bayesian estimation of membership uncertainty in model‐based clustering
Authors: Chen Liyuan , Brown Steven D.
Published: July 2013

We report the use of a cluster analysis method based on a multivariate mixture model, known as model‐based clustering, for overcoming the limitations of hierarchical clustering and relocation clustering. Unlike traditional clustering methods in which clusters are formed on the basis of intercluster distances, model‐based clustering classifies observations on the basis of probability estimated from Gaussian mixture modeling, and its statistical basis allows for inference. Three examples are given in which we demonstrate that model‐based clustering gives much better performance for overlapping clusters, a more reliable determination of the number of clusters in data, and better identification of clustering in the presence of outliers than agglomerative hierarchical clustering or iterative relocation clustering using aK‐means criterion. We also show that Markov chain Monte Carlo simulation, as implemented via Gibbs sampling coupled with model‐based clustering, may be used to assess uncertainty of group memberships. Copyright © 2013 John Wiley & Sons, Ltd.
Towards the Development of a Selective Ruthenium‐Catalyzed Hydroformylation of Olefins
Authors: Fleischer Ivana , Wu Lipeng , Profir Irina , Jackstell Ralf , Franke Robert , Beller Matthias
Published: July 2013

The ruthenium‐catalyzed hydroformylation of 1‐ and 2‐octene to give preferentially the corresponding linear aldehyde is reported. The catalyst system comprising of Ru3(CO)12 and an imidazole‐substituted monophosphine ligand allows for high chemo‐ and regioselectivity. The hydroformylation proceeds with unprecedented rates for a ruthenium‐based catalyst.
Stereocomplementary Routes to Hydroxylated Nitrogen Heterocycles: Total Syntheses of Casuarine, Australine, and 7‐epi‐Australine
Authors: Parmeggiani Camilla , Cardona Francesca , Giusti Leonardo , Reissig Hans‐Ulrich , Goti Andrea
Published: July 2013

Addition of lithiated 1‐benzyloxyallene to a D‐arabinose‐derived cyclic nitrone occurred with perfect diastereoselectivity furnishing a bicyclic 1,2‐oxazine derivative, which is an excellent precursor for pyrrolizidine alkaloids hydroxylated at C‐7 with optional configuration at this stereogenic center. Depending on the stage of the NO bond cleavage and ring re‐closure, 7‐hydroxypyrrolizidines with 7R or 7S configuration were obtained, as a result of completely selective addition reactions occurring complementarily at the bottom or top face of the endocyclic CC double bond in six‐ and five‐membered B rings, respectively. Applicability of these stereodivergent routes to obtain polyhydroxy pyrrolizidine alkaloids is demonstrated by the efficient syntheses of casuarine and australine as examples of the two classes of diversely configured 7‐hydroxypyrrolizidine alkaloids. An alternative synthesis of australine and two strategies for the preparation of 7‐epi‐australine are also reported, which demonstrate that the stereoselectivity of hydride reduction of an exocyclic CO double bond is independent of the ring size, occurring preferentially from the top face either in a six‐ or five‐membered ring.
ChemInform Abstract: New Polymorph of the Highly Efficient LED‐Phosphor SrSi2O2N2:Eu2+ — Polytypism of a Layered Oxonitridosilicate.
Authors: Seibald Markus , Rosenthal Tobias , Oeckler Oliver , Maak Christian , Tuecks Andreas , Schmidt Peter J. , Wiechert Detlef , Schnick Wolfgang
Published: July 2013

SrSi2O2N2:Eu2+ (2 mol% Eu) is prepared by solid state reaction of a stoichiometric mixture of Sr2SiO4:Eu2+ and Si3N4 (W foil in Mo crucible,1540 °C, 16 h).
ChemInform Abstract: Electrical and Thermal Transport Properties of AgIn5Te8.
Authors: Pei Yan‐Ling , Zhang Chaolei , Li Jing , Sui Jiehe
Published: July 2013

AgIn5Te8 is synthesized by reactive melting of a stoichiometric mixture of Ag, In, and Te (C‐coated evacuated fused silica tube, 1073 K, 6 h).
ChemInform Abstract: Transport Properties of an Intermetallic with Pseudo‐hollandite Structure as a Potential Thermoelectric Material: The Example of TlxCr5Se8.
Authors: Takahashi Hidefumi , Raghavendra Nunna , Gascoin Franck , Pelloquin Denis , Hebert Sylvie , Guilmeau Emmanuel
Published: July 2013

Phase‐pure TlxCr5Se8 (x ≤ 1, not determined precisely) is prepared by melting stoichiometric amounts of the elements (1.
ChemInform Abstract: Microwave Synthesis of Au—Rh Core—Shell Nanoparticles and Implications of the Shell Thickness in Hydrogenation Catalysis.
Authors: Garcia Stephany , Anderson Rachel M. , Celio Hugo , Dahal Naween , Dolocan Andrei , Zhou Jiping , Humphrey Simon M.
Published: July 2013

Au—Rh core—shell nanoparticles with tuneable shell thicknesses are prepared from mixtures of specific quantities of RhCl3 (dependent on the desired shell thickness) in ethylene glycol and Au nanoparticles under microwave‐assisted heating at 150 °C.
ChemInform Abstract: [H(OXeF2)n][AsF6] and [FXeII(OXeIVF2)n] [AsF6] (n = 1, 2): Examples of Xenon(IV) Hydroxide Fluoride and Oxide Fluoride Cations and the Crystal Structures of [F3Xe—FH][Sb2F11] and [H5F4][SbF6]·2 [F3Xe—FH][Sb2F11].
Authors: Brock David S. , Mercier Helene P. A. , Schrobilgen Gary J.
Published: July 2013

The title compounds are synthesized as natural abundant and 18O‐ and 2H‐enriched salts.
ChemInform Abstract: Structural Evidence for Undecabromide [Br11]‐.
Authors: Haller Heike , Schroeder Jan , Riedel Sebastian
Published: July 2013

[PPN][Br11·Br2] (PPN: bis(triphenylphosphine)iminium) is synthesized in pure elemental bromine by adding or condensing bromine to [PPN]Br in a 1:6 ratio at room temperature for several days.
ChemInform Abstract: Fast Ion Conducting Nanocrystalline Alkaline Earth Fluorides Simply Prepared by Mixing or Manual Shaking.
Authors: Scholz Gudrun , Meyer Klas , Duevel Andre , Heitjans Paul , Kemnitz Erhard
Published: July 2013

Nanocrystalline phase‐pure metal fluorides MF2 (M: Ca, Sr, Ba) are obtained by simple mixing or shaking of alkaline earth hydroxides with NH4F.
ChemInform Abstract: Solvothermal Synthesis, Crystal Structure, and Strong Luminescence of the First Organic‐Templated Europium Sulfate Chloride.
Authors: Zhou Wanli , Chen Lei , Xu Yan
Published: July 2013

The new compound (II) is characterized by single crystal XRD and photoluminescence spectroscopy.
ChemInform Abstract: Synthesis, Crystal Structure, Magnetic Property, and Electronic Structure of Ba2YbInSe5.
Authors: Feng Kai , Yin Wenlong , Wang Wendong , Kang Lei , Hao Wenyu , Yao Jiyong , Shi Youguo , Lin Zheshuai , Wu Yicheng
Published: July 2013

The new title compound is synthesized by solid state reaction of BaSe, In2Se3, Yb, and Se in the molar ratio 4:1:2:3 (1173 K, 72 h).
ChemInform Abstract: Formation of TbCu7‐Type CeFe10Zr0.8 by Rapid Solidification.
Authors: Zhou Chen , Pinkerton Frederick E. , Herbst Jan F.
Published: July 2013

The title intermetallic compound is prepared by melt spinning of induction melted ingots of nominal composition CeFe11Zr followed by ball milling into a powder.
ChemInform Abstract: K13CoSn17‐x (x = 0.1): A New Ternary Phase Containing Cobalt Centered [Sn9] Cluster Synthesized via High‐Temperature Reaction.
Authors: Yue Cheng‐Yang , Wang Ming‐Feng , Yuan Zhuang‐Dong , Zhou Fang‐Xia , Zhang Hui‐Ping , Lei Xiao‐Wu
Published: July 2013

The title compound is prepared from the elements (Nb tube, 850 °C, 5 d) and characterized by single crystal XRD.
ChemInform Abstract: Oxidation of Alcohols and Pyridines by a Water‐Soluble Polyoxometalate with Hydrogen Peroxide.
Authors: Zhang Zhenxin , Zhu Qianqian , Ding Yong
Published: July 2013

K8[β‐SiW11O39]·14 H2O is used as catalyst for the oxidation of alcohols and pyridines in aqueous solution using hydrogen peroxide as the oxidant.
ChemInform Abstract: Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of an o‐Nitrobenzenesulfonyl Group.
Authors: Kawanishi Akinori , Miyamoto Chiyako , Yabe Yuki , Inai Makoto , Asakawa Tomohiro , Hamashima Yoshitaka , Sajiki Hironao , Kan Toshiyuki
Published: July 2013

Hydrogenation of unsaturated compounds bearing the sensitive o‐nitrobenzenesulfonyl amide moiety affords the corresponding saturated compounds without loss of the nitro group, utilizing a hydrogen balloon and the Pd/MS3A catalytic system.
ChemInform Abstract: Late‐Stage Deoxyfluorination of Alcohols with PhenoFluor.
Authors: Sladojevich Filippo , Arlow Sophie I. , Tang Pingping , Ritter Tobias
Published: July 2013

The reaction proceeds considerably faster if less sterically hindered or allylic alcohols are deployed.
ChemInform Abstract: Schmidt Reaction in Ionic Liquids: Highly Efficient and Selective Conversion of Aromatic and Heteroaromatic Aldehydes to Nitriles with [BMIM(SO3H)][OTf] as Catalyst and [BMIM][PF6] as Solvent.
Authors: Nandi Ganesh C. , Laali Kenneth K.
Published: July 2013

Notable features of the method are high yields, simple product isolation and no need for liquid superacids or corrosive Lewis acids, commonly employed for this conversion.
ChemInform Abstract: Ketene Three‐Component Reaction: A Metal‐Free Multicomponent Approach to Stereodefined Captodative Olefins.
Authors: Basso Andrea , Banfi Luca , Garbarino Silvia , Riva Renata
Published: July 2013

The photoinduced three‐component reaction between diazoketones, carboxylic acids and isocyanides is reported.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Acyloxylation/Carbocyclization of Allenynes.
Authors: Deng Youqian , Baeckvall Jan‐E.
Published: July 2013

The method offers a useful access to a broad spectrum of acyloxylated vinylallenes.
ChemInform Abstract: Protecting Group Free Diastereoselective C—C Coupling of 1,3‐Glycols and Allyl Acetate Through Site‐Selective Primary Alcohol Dehydrogenation.
Authors: Dechert‐Schmitt Anne‐Marie R. , Schmitt Daniel C. , Krische Michael J.
Published: July 2013

The direct allylation of various chiral diols is achieved with a Segphos‐derived iridium catalyst without the need for protecting groups, chiral auxiliaries and premetalated reagents.
ChemInform Abstract: A Catalytic Enantioselective Tandem Allylation Strategy for Rapid Terpene Construction: Application to the Synthesis of Pumilaside Aglycon.
Authors: Ferris Grace E. , Hong Kai , Roundtree Ian A. , Morken James P.
Published: July 2013

Catalytic diboration of dienes followed by cascade allylborations with dicarbonyl compounds opens access towards terpenoid cyclohexane derivatives.
ChemInform Abstract: Copper/Palladium‐Catalyzed 1,4 Reduction and Asymmetric Allylic Alkylation of α,β‐Unsaturated Ketones: Enantioselective Dual Catalysis.
Authors: Nahra Fady , Mace Yohan , Lambin Dominique , Riant Olivier
Published: July 2013

The transformation proceeds via silyl enolates derived from cyclic enones.
ChemInform Abstract: Direct Catalytic Asymmetric Alkynylation of Ketoimines.
Authors: Yin Liang , Otsuka Yasunari , Takada Hisashi , Mouri Shinsuke , Yazaki Ryo , Kumagai Naoya , Shibasaki Masakatsu
Published: July 2013

An efficient protocol for the direct catalytic alkynylation of ketoimines is reported.
ChemInform Abstract: Atom‐Economical Chemoselective Synthesis of 1,4‐Enynes from Terminal Alkenes and Propargylic Alcohols Catalyzed by Cu(OTf)2.
Authors: Huang Guo‐Bao , Wang Xu , Pan Ying‐Ming , Wang Heng‐Shan , Yao Gui‐Yang , Zhang Ye
Published: July 2013

This reaction works with aromatic olefins as nucleophiles giving 1,4‐enynes in high yields.
ChemInform Abstract: Palladium‐Catalyzed Highly Selective ortho‐Halogenation (I, Br, Cl) of Arylnitriles via sp2 C—H Bond Activation Using Cyano as Directing Group.
Authors: Du Bingnan , Jiang Xiaoqing , Sun Peipei
Published: July 2013

This method tolerates a variety of functional groups and gives the ortho‐halogenated arylnitriles in good yields.
ChemInform Abstract: The Enantioselective Trifluoromethylation of Aromatic Aldehydes by Quaternary Ammonium Bromide and (IPr)CuF at Low Catalyst Loading.
Authors: Wu Shaoxiang , Guo Jiyi , Sohail Muhammad , Cao Chengyao , Chen Fu‐Xue
Published: July 2013

Several quinidine‐derived quaternary ammonium salts are tested as catalysts for the enantioselective trifluoromethylation of aromatic aldehydes.
ChemInform Abstract: Organocatalytic Direct Asymmetric Crossed‐Aldol Reactions of Acetaldehyde in Aqueous Media.
Authors: Qiao Yupu , Chen Qiankun , Lin Sirong , Ni Bukuo , Headley Allan D.
Published: July 2013

A new catalyst system consisting of a diarylprolinole DOP and a newly developed ionic liquid supported benzoic acid (ILS) as co‐catalyst, is used for the asymmetric direct crossed‐aldol reaction of acetaldehyde in aqueous media using brine.
ChemInform Abstract: Decarboxylative Mannich Reactions.
Authors: Boehm Maximillian , Proksch Kerstin , Mahrwald Rainer
Published: July 2013

The reaction of various aromatic and aliphatic imines with β‐keto carboxylic acids does not require any catalyst.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Aromatic Carboxylic Acids with Silacarboxylic Acids.
Authors: Friis Stig D. , Andersen Thomas L. , Skrydstrup Troels
Published: July 2013

Benzoic acids are accessible from aryl and heteroaryl iodides and bromides by employing a silacarboxylic acid as an in situ carbon monoxide source under Pd‐catalysis.
ChemInform Abstract: Amino Phosphate Monoesters: A Convenient Source of 2‐Alkylamino‐3‐methoxy‐3‐phenylpropionates via Aziridinium Ions.
Authors: Kaabi Amani , Besbes Rafaa
Published: July 2013

The two‐step method for the synthesis of the title compounds (V) involves phosphorylation of the corresponding amino alcohols and subsequent double displacement via an aziridinium intermediate.
ChemInform Abstract: An Unprecedented Use for Glycerol: Chemoselective Reducing Agent for Sulfoxides.
Authors: Garcia Nuria , Garcia‐Garcia Patricia , Fernandez‐Rodriguez Manuel A. , Garcia Daniel , Pedrosa Maria R. , Arnaiz Francisco J. , Sanz Roberto
Published: July 2013

A molybdenum catalyst is found to be highly efficient for the chemoselective deoxygenation of sulfoxides to afford the corresponding sulfides.
ChemInform Abstract: An Improved Synthesis of Vinyl‐ and β‐Iodovinyl Sulfones by a Molecular Iodine‐Mediated One‐Pot Iodosulfonation‐Dehydroiodination Reaction.
Authors: Sawangphon Tassaporn , Katrun Praewpan , Chaisiwamongkhol Korbua , Pohmakotr Manat , Reutrakul Vichai , Jaipetch Thaworn , Soorukram Darunee , Kuhakarn Chutima
Published: July 2013

An improved one‐pot method for the synthesis of vinyl sulfones from unsaturated systems is described.
ChemInform Abstract: An Efficient Method for Sterically Demanding Suzuki—Miyaura Coupling Reactions.
Authors: Zhao Qing , Li Chengxi , Senanayake Chris H. , Tang Wenjun
Published: July 2013

An efficient method for sterically demanding Suzuki—Miyaura coupling reactions is developed.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Symmetrical Biaryls under Microwave Irradiation and Conventional Heating.
Authors: Hajipour Abdol Reza , Rafiee Fatemeh
Published: July 2013

The palladium‐catalyzed synthesis of symmetrical biaryls is described.
ChemInform Abstract: Lewis Acid‐Catalyzed Ring‐Opening Functionalizations of 1,4‐Epoxy‐1,4‐dihydronaphthalenes.
Authors: Sawama Yoshinari , Ogata Yuta , Kawamoto Koichi , Satake Hiroyuki , Shibata Kyoshiro , Monguchi Yasunari , Sajiki Hironao , Kita Yasuyuki
Published: July 2013

A novel Lewis acid‐catalyzed ring‐opening allylation, cyanation and azidation of 1,4‐disubstituted 1,4‐epoxynaphthalenes is reported.
ChemInform Abstract: Squaric Acid Catalyzed Simple Synthesis of N‐Substituted Pyrroles in Green Reaction Media
Authors: Azizi Najmadin , Davoudpour Anahita , Eskandari Farshid , Batebi Ehlham
Published: July 2013

via reaction of tetrahydrofuran (I) or 2,5‐hexanedione with aryl amines
ChemInform Abstract: The Quinine Thiourea‐Catalyzed Asymmetric Strecker Reaction: An Approach for the Synthesis of 3‐Aminooxindoles.
Authors: Wang Dong , Liang Jinyan , Feng Jingchao , Wang Kairong , Sun Quantao , Zhao Long , Li Dan , Yan Wenjin , Wang Rui
Published: July 2013

An organocatalytic enantioselective Strecker reaction for the synthesis of title compounds (III) and (V) is developed.
ChemInform Abstract: Highly Efficient and Stereocontrolled Construction of 3,3′‐Pyrrolidonyl Spirooxindoles via Organocatalytic Domino Michael/Cyclization Reaction.
Authors: Liu Xiong‐Li , Han Wen‐Yong , Zhang Xiao‐Mei , Yuan Wei‐Cheng
Published: July 2013

Structurally diverse 3,3′‐thiopyrrolidonyl spirooxindoles bearing three contiguous stereogenic centers can be smoothly prepared via domino Michael/cyclization reaction using quinine as chiral catalyst.
ChemInform Abstract: Synthesis of Functionalized Spiroindolines via Palladium‐Catalyzed Methine C—H Arylation.
Authors: Saget Tanguy , Perez David , Cramer Nicolai
Published: July 2013

The intramolecular Pd‐catalyzed methine C‐H arylation provides a convenient access to conformationally constrained spiroindolines.
ChemInform Abstract: Synthesis of Anticancer Compounds 2‐(4‐Amino‐2‐arylaminothiazol‐5‐oyl)‐N‐methylbenzimidazoles.
Authors: Paul S. Selvin Pragalath , Yardily A. , Rajasekharan K. N. , Abbs Fen Reji T. F.
Published: July 2013

Benzimidazole derivatives (III) are obtained by [4+1] heterocyclization of thiourea derivatives (II) and benzimidazole derivatives (I).
ChemInform Abstract: Synthesis of 2‐Substituted Benzothiazoles from 1‐Iodo‐2‐nitrobenzenes by a Copper‐Catalyzed One‐Pot Three‐Component Reaction.
Authors: Liu Jidan , Gui Qingwen , Yang Zhiyong , Tan Ze , Guo Ruqing , Shi Ji‐Cheng
Published: July 2013

A broad spectrum of 2‐substituted benzothiazoles is available in the presence of sodium sulfide, where a wide range of functional groups is tolerated at the arene moieties of the substrates.
ChemInform Abstract: Synthesis of Tetrazole‐Substituted Spirocyclic γ‐Lactams by One‐Pot Azido‐Ugi Reaction—Cyclization.
Authors: Stolyarenko Vasiliy Yu. , Evdokimov Anatoliy A. , Shishkin Vladimir I.
Published: July 2013

20 Title compounds of type (VII) are prepared with the azido‐Ugi reaction of primary amines (V), isonitriles (VI), and trimethylsilyl azide as key step.
ChemInform Abstract: Squaramide—Tertiary Amine Catalyzed Asymmetric Cascade Sulfa‐Michael/Michael Addition via Dynamic Kinetic Resolution: Access to Highly Functionalized Chromans with Three Contiguous Stereocenters.
Authors: Yang Wen , Yang Yi , Du Da‐Ming
Published: July 2013

An efficient squaramide‐catalyzed asymmetric cascade sulfa‐Michael/Michael addition of mainly thiosalicylates with nitroalkene enoates for the construction of highly functionalized chromanes containing three contiguous stereocenters is described.
ChemInform Abstract: New Synthetic Approaches to Substituted Pyridine‐2‐(1H)‐ones Clubbed with Substituted Aryl Diazo Substituents.
Authors: Patel Navin B. , Sharma Rakesh D.
Published: July 2013

A series of title compounds of type (VIII) and (IX) are prepared (no yields given) and tested for their antimicrobial and antitubercular activities.
ChemInform Abstract: Access to 2,6‐Disubstituted Piperidines: Control of the Diastereoselectivity, Scope, and Limitations. Applications to the Stereoselective Synthesis of (—)‐Solenopsine A and Alkaloid (+)‐241D.
Authors: Abrunhosa‐Thomas Isabelle , Plas Aurelie , Vogrig Alexandre , Kandepedu Nishanth , Chalard Pierre , Troin Yves
Published: July 2013

The cis/trans selectivity is influenced by the alcohol used for the in situ acetalization.
ChemInform Abstract: Stereoselective Synthesis of Spiropiperidines as BACE‐1 Aspartyl Protease Inhibitors via Late Stage N‐Arylation of a 1,8‐Diazaspiro[4.5]dec‐3‐en‐2‐one Pharmacophore.
Authors: Lee Che‐Wah , et al. et al.
Published: July 2013

In contrast to other known methods to synthesize target compound (XI), this new stereoselective synthesis is based upon the late stage N‐arylation of (VIII) employing the stereospecific Corey—Link reaction.
ChemInform Abstract: Complex Bioactive Alkaloid‐Type Polycycles Through Efficient Catalytic Asymmetric Multicomponent Aza‐Diels—Alder Reaction of Indoles with Oxetane as Directing Group.
Authors: Chen Zhilong , Wang Beilei , Wang Zhaobin , Zhu Guangyu , Sun Jianwei
Published: July 2013

The title reaction provides rapid access to a variety of molecules that contain indoline, tetrahydroquinoline, and tetrahydroisoquinoline moieties.
ChemInform Abstract: Sulfonylation of Quinoline N‐Oxides with Aryl Sulfonyl Chlorides via Copper‐Catalyzed C—H Bonds Activation.
Authors: Wu Zhiyong , Song Hongyu , Cui Xiuling , Pi Chao , Du Weiwei , Wu Yangjie
Published: July 2013

An efficient protocol for preparation of sulfonylated quinoline N‐oxides via Cu‐catalyzed C—H bond activation is developed.
ChemInform Abstract: Metal‐Free Cross‐Dehydrogenative Coupling of Heterocycles with Aldehydes.
Authors: Matcha Kiran , Antonchick Andrey P.
Published: July 2013

A range of heterocyclic ketone derivatives are synthesized by a novel, metal‐free cross‐dehydrogenative coupling between heterocycles and aldehydes under mild reaction conditions that are not sensitive to moisture.
ChemInform Abstract: Relay Catalysis by a Ruthenium Complex—Chiral Broensted Acid Binary System for Ternary Reaction Sequence Involving Enantioselective Pictet—Spengler‐Type Cyclization as the Key Step.
Authors: Toda Yasunori , Terada Masahiro
Published: July 2013

The enamide substrates undergo double‐bond isomerization, protonation, and enantioselective Pictet—Spengler‐type cyclization.
ChemInform Abstract: Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition of Oximes and Diynes to Give Pyridines.
Authors: Xu Fen , Wang Chunxiang , Wang Dongping , Li Xincheng , Wan Boshun
Published: July 2013

A rhodium‐complex catalyzed cycloaddition of diynes and oximes is described.
ChemInform Abstract: An Efficient Synthesis of 1‐Methyl‐4,5,6,7‐tetrahydro‐1H‐pyrrolo[2,3‐c]pyridine and Its N6‐Substituted Analogues.
Authors: Nechayev Maxim A. , Gorobets Nikolay Yu. , Kovalenko Sergiy M. , Tolmachev Andrey A.
Published: July 2013

An improved method for the preparation of the pyrrolopyridine nucleus (V), isosteric to known annulated heterocyclic drug skeletons, is described.
ChemInform Abstract: Synthesis and Glycosidase Inhibitory Activity of Novel (2‐Phenyl‐4H‐benzopyrimido[2,1‐b]‐thiazol‐4‐yliden)acetonitrile Derivatives (III).
Authors: Patil Vijay S. , Nandre Kamalakar P. , Ghosh Sougata , Rao Vaidya Jayathirtha , Chopade Balu A. , Bhosale Sheshanath V. , Bhosale Sidhanath V.
Published: July 2013

Compounds (IIIg) and (IIIh) show excellent α‐amylase inhibition, whereas compounds (IIIe) and (IIIf) exhibit very high glucosidase inhibition.
ChemInform Abstract: Synthesis and anti‐HIV Activity of New Fused Chromene Derivatives Derived from 2‐Amino‐4‐(1‐naphthyl)‐5‐oxo‐4H,5H‐pyrano [3,2‐c]chromene‐3‐carbonitrile.
Authors: Al‐Masoudi Najim A. , Mohammed Hamid H. , Hamdy Aws M. , Akrawi Omer A. , Eleya Nadi , Spannenberg Anke , Pannecouque Christophe , Langer Peter
Published: July 2013

New chromene derivatives (III), (IV), and (X) inhibit HIV‐1 and HIV‐2 replication in cell cultures, with compound (III) being the most active one.
ChemInform Abstract: Iron‐Catalyzed Cross‐Coupling of Electron‐Deficient Heterocycles and Quinone with Organoboron Species via Innate C—H Functionalization: Application in Total Synthesis of Pyrazine Alkaloid Botryllazine A.
Authors: Singh Parvinder Pal , Aithagani Sravan Kumar , Yadav Mahipal , Singh Varun Pratap , Vishwakarma Ram A.
Published: July 2013

This reaction works under open flask conditions.
ChemInform Abstract: Visible Light Photooxidative Cyclization of Amino Alcohols to 1,3‐Oxazines.
Authors: Mathis Cheryl L. , Gist Brandi M. , Frederickson Conerd K. , Midkiff Katie M. , Marvin Christopher C.
Published: July 2013

The process proceeds through formation of iminium ions which are trapped by the internal OH group.
ChemInform Abstract: Copper‐Catalyzed Tandem C—C/C—O Bond‐Forming Reactions of ortho‐Halo‐β‐chlorostyrenes with Ketones: Synthesis of 4‐Trifluoromethylbenzoxepines.
Authors: Sun Lei‐Lei , Hu Bo‐Lun , Tang Ri‐Yuan , Deng Chen‐Liang , Zhang Xing‐Guo
Published: July 2013

The annulation reaction involves the direct α‐alkenylation of ketones (II) and a subsequent intramolecular O‐arylation process affording title compounds (III) in moderate to good yields.
ChemInform Abstract: P‐Directed Borylation of Phenols.
Authors: Cazorla Clement , De Vries Timothy S. , Vedejs Edwin
Published: July 2013

Internal borylation occurs upon activation of aryl di‐isopropylphosphinite boranes with HNTf2 giving heterocyclic intermediates leading either to (II) or phenolic potassium salts (VI).
ChemInform Abstract: Stereoselective Synthesis of β‐Glycosyl Thiols and Their Synthetic Applications.
Authors: Jana Manas , Misra Anup Kumar
Published: July 2013

This new method to prepare β‐glycosyl thiol derivatives in one‐step is fast, high yielding, highly stereoselective, and requires only benchtop chemicals.
ChemInform Abstract: Bulk Synthesis of Iron‐Based Superconductors
Authors: Sefat Athena S.
Published: July 2013

Review: 58 refs.
ChemInform Abstract: Elaborate Metallosupramolecular Architectures Through Desymmetrization Self‐Assembly of Symmetric Building Blocks
Authors: Nakamura Takashi , Ube Hitoshi , Shionoya Mitsuhiko
Published: July 2013

Review: <35 refs.
ChemInform Abstract: Organic Stereochemistry. Part 3. Other Stereogenic Elements: Axes of Chirality, Planes of Chirality, Helicity, and (E,Z)‐Diastereoisomerism
Authors: Testa Bernard
Published: July 2013

Review: 64 refs.
ChemInform Abstract: An Overview of Synthetic Approaches for Heterocyclic Steroids
Authors: Singh Ritesh , Panda Gautam
Published: July 2013

Review: < 100 refs.
ChemInform Abstract: Asymmetric Hydroamination: A Survey of the Most Recent Developments
Authors: Hannedouche Jerome , Schulz Emmanuelle
Published: July 2013

Review: ca. 150 refs.
ChemInform Abstract: Protein Organic Chemistry and Applications for Labeling and Engineering in Live‐Cell Systems
Authors: Takaoka Yousuke , Ojida Akio , Hamachi Itaru
Published: July 2013

Review: 151 refs.
ChemInform Abstract: Recent Developments in Asymmetric Phase‐Transfer Reactions
Authors: Shirakawa Seiji , Maruoka Keiji
Published: July 2013

Review: about 200 refs.
ChemInform Abstract: Lower and Upper Rim Modified Derivatives of 1,3,5‐Triaza‐7‐phosphaadamantane: Coordination Chemistry and Applications in Catalytic Reactions in Water
Authors: Gonsalvi Luca , Guerriero Antonella , Hapiot Frederic , Krogstad Donald A. , Monflier Eric , Reginato Gianna , Peruzzini Maurizio
Published: July 2013

Review: 30 refs.
ChemInform Abstract: Metal‐Mediated Coupling of Carbon Dioxide and Aryl/Vinyl Chlorides under Ambient Conditions
Authors: Kleij Arjan W.
Published: July 2013

Review: 44 refs.
ChemInform Abstract: DNA as a Tool for Molecular Discovery
Authors: Smietana Michael , Vasseur Jean‐Jacques , Cossy Janine , Arseniyadis Stellios
Published: July 2013

Review: 74 refs.
ChemInform Abstract: From Soluble to Supported Iridium Metal Nanoparticles — Active and Recyclable Catalysts for Hydrogenation Reactions
Authors: Scholten Jackson D.
Published: July 2013

Review: 105 refs.
ChemInform Abstract: Soluble Nickel Nanoparticles for Catalytic Hydrogenation
Authors: Yu Yinyin , Hou Zhenshan
Published: July 2013

Review: 93 refs.
ChemInform Abstract: Catalytic Asymmetric Construction of Stereogenic Carbon Centers That Feature a gem‐Difluoroalkyl Group
Authors: Liu Yun‐Lin , Yu Jin‐Sheng , Zhou Jian
Published: July 2013

Review: 134 refs.
ChemInform Abstract: Poly(o‐aminophenol) Film Electrodes: Synthesis and Characterization and Formation Mechanisms
Authors: Tucceri R. , Arnal P. M. , Scian A. N.
Published: July 2013

Review: 46 refs.
ChemInform Abstract: Phosphine Organocatalysis in the Synthesis of Natural Products and Bioactive Compounds
Authors: Gomez Catherine , Betzer Jean‐Francois , Voituriez Arnaud , Martinetti Angela
Published: July 2013

Review: 47 refs.
ChemInform Abstract: Aqueous Microemulsions as Efficient and Versatile Media for Transition‐Metal‐Catalyzed Reactions
Authors: Taylor Jason G. , Ferrari Jailton
Published: July 2013

Review: ca. 50 refs.
ChemInform Abstract: Chemical Probing of Glycans in Cells and Organisms
Authors: Rouhanifard Sara H. , Nordstroem Lars Ulrik , Zheng Tianqing , Wu Peng
Published: July 2013

Review: 60 refs.
ChemInform Abstract: Glycopolymer Probes of Signal Transduction
Authors: Kiessling Laura L. , Grim Joseph C.
Published: July 2013

Review: 212 refs.
ChemInform Abstract: Recent Advances in Malaria Drug Discovery
Authors: Biamonte Marco A. , Wanner Jutta , Le Roch Karine G.
Published: July 2013

Review: 202 refs.
ChemInform Abstract: Some Remarks on Direct Solid Fuel Combustion Using Chemical Looping Processes
Authors: Zeng Liang , Kathe Mandar V. , Chung Elena Y. , Fan Liang‐Shih
Published: July 2013

Review: 48 refs.
ChemInform Abstract: Process and Reaction Monitoring by Low‐Field NMR Spectroscopy
Authors: Dalitz Franz , Cudaj Markus , Maiwald Michael , Guthausen Gisela
Published: July 2013

Review: 275 refs.
Secure similarity coefficients computation for binary data and its extensions
Authors: Zhang Bo , Zhang Fangguo
Published: July 2013

Similarity measures play an important role in classification problems, cluster analysis, and identification issues. This paper studies the secure similarity coefficients computation in the two‐party setting. Recently, a privacy‐preserving similarity coefficients protocol for binary data was proposed by Wong and Kim (Computers and Mathematics with Application 2012). We point out that their protocol is not secure, even in the semi‐honest model. In their protocol, the client can retrieve the inputs of the server without deviating from the protocol. Next, we propose a secure similarity coefficients computation protocol in the presence of malicious adversaries, which solves the same similarity coefficients functionality as that proposed by Wong and Kim. Meanwhile, we prove the protocol secure against the malicious adversaries by using the standard simulation‐based security definitions for secure two‐party computation. Also several extensions of our protocol for settling other specific problems are discussed. At last, we present a protocol computing the similarity coefficients with better privacy by using the secure integer division on ciphertexts. Copyright © 2013 John Wiley & Sons, Ltd.
Differences in Cucurbit[7]uril: Surfactant Complexation Promoted by the Cationic Head Group
Authors: Pessêgo Márcia , Da Silva José P. , Moreira José A. , García‐Río Luis
Published: July 2013

The formation of host/guest complexes between cucurbit[7]uril (CB7) and tetradecyltrialkylammonium bromide surfactants with trimethyl (C14TMA+), triethyl (C14TEA+), and tripropyl (C14TPA+) head groups was studied. Complexation was studied by ESI‐MS, isothermal titration calorimetry (ITC), and NMR spectroscopy. The structure of the complexes is strongly dependent on the surfactant head group. Both 1:1 and 2:1 complexes are formed with all cationic surfactants. The magnitude of the K1:1 binding constants decreases with the alkyl length of the head group, whereas that of the K2:1 binding constants is independent of the nature of the surfactant head group. Distinct structures were found for the 1:1 and 2:1 complexes. C14TMA+ and C14TPA+ surfactants form 1:1 inclusion complexes that comprise the head group close to the CB7 portal and 2:1 external complexes with both host molecules near the head group. The 1:1 complexes between C14TEA+ and CB7 showed that the head group was centered inside the CB7 cavity, whereas in the 2:1 complex the second molecule of CB7 was located at the end of the main alkyl chain.
How Customer Support for Corporate Social Responsibility Influences the Image of Companies: Evidence from the Banking Industry
Authors: Pérez Andrea , del Bosque Ignacio Rodríguez
Published: July 2013

The authors of this paper carry out two studies to determine whether customer support for corporate social responsibility (CSR support) influences the way customers form their perceptions of CSR practices in the banking industry. Study 1 consists of a cluster analysis which provides information about four customer groups classified according to their support for CSR practices. These groups are labelled as the ‘low support’, ‘social orientation’, ‘individual benefit’, and ‘high support’ clusters. In Study 2, the authors test whether differences exists in the way the four clusters process their CSR perceptions. The results confirm the relevance of motivational attribution when socially oriented and highly involved customers evaluate CSR. Based on this information, the authors provide several recommendations for managers to effectively design and communicate their CSR strategies. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
Therapeutic hope for psoriasis offered by SOCS (suppressor of cytokine signaling) mimetic peptide
Authors: Kubo Masato
Published: July 2013

The cytokine network has a pivotal role in maintaining skin homeostasis, and the disturbance of this network can lead to skin pathogenesis. Evidence published in this issue of the European Journal of Immunology by Madonna et al. [Eur. J. Immunol. 2013. 43: 1883–1895], together with other recent data, focuses attention on a negative cytokine regulator, namely SOCS 1 (suppressor of cytokine signaling 1) in immune‐mediated skin disease. In addition, Madonna et al. bring new perspectives regarding the therapeutic control of IFN‐γ‐mediated skin pathogenesis by use of a SOCS 1 mimetic peptide.
Studies of Reversible Conjugate Additions
Authors: Zhong Ye , Xu Yufang , Anslyn Eric V.
Published: July 2013

Benzalcyanoacetamides were designed and synthesized as reversible thiol conjugate addition acceptors. These thia‐conjugate additions can rapidly and reversibly achieve equilibrium under aqueous conditions at neutral pH. Kinetic studies show that electron‐withdrawing groups at the 4‐position of the phenyl ring of the benzalcyanoacetamides promote the conjugate addition at equilibrium. Dynamic thiol exchange of these conjugate acceptors is faster than singly activated α,β‐unsaturated carbonyl compounds. These thia‐conjugate additions can be assembled as potentially useful components in dynamic combinatorial chemistry.
Unstructured finite element method for the solution of the Boussinesq problem in three dimensions
Authors: Smethurst C.A. , Silvester D.J. , Mihajlović M.D.
Published: July 2013

We present a numerical method for the monolithic discretisation of the Boussinesq system in three spatial dimensions. The key ingredients of the proposed methodology are the finite element discretisation of the spatial part of the problem using unstructured tetrahedral meshes, an implicit time integrator, based on adaptive predictor–corrector scheme (the explicit second‐order Adams–Bashforth method with the implicit stabilised trapezoid rule), and a new preconditioned Krylov subspace solver for the resulting linearised discrete problem. We test the proposed methodology on a number of physically relevant cases, including laterally heated cavities and the Rayleigh–Bénard convection. Copyright © 2013 John Wiley & Sons, Ltd.
Strategies to reduce long‐term postchemoradiation dysphagia in patients with head and neck cancer: An evidence‐based review
Authors: Paleri Vinidh , Roe Justin W. G. , Strojan Primož , Corry June , Grégoire Vincent , Hamoir Marc , Eisbruch Avraham , Mendenhall William M. , Silver Carl E. , Rinaldo Alessandra , Takes Robert P. , Ferlito Alfio
Published: July 2013

Background

Swallowing dysfunction following chemoradiation for head and neck cancer is a major cause of morbidity and reduced quality of life. This review discusses 3 strategies that may improve posttreatment swallowing function.

Methods

The literature was assessed by a multiauthor team that produced evidence‐based recommendations.

Results

(1) Prospective and randomized studies with small cohorts show a trend toward benefits for a preventative exercise program addressing oral and pharyngeal structures. (2) Prospective and retrospective data indicate that better swallowing outcomes are likely when nasogastric tubes are used in preference to gastrostomy tubes to supplement enteral nutrition during chemoradiation. (3) Emerging prospective data with mature results on small cohorts support the hypothesis that radiation dose restriction to swallowing structures using intensity‐modulated radiation therapy techniques leads to better swallow outcomes.

Conclusions

This study discusses 3 strategies for improving swallow‐related outcomes in patients undergoing chemoradiation for head and neck cancer and identifies areas for future research. © 2013 Wiley Periodicals, Inc. Head Neck 36: 431–443, 2014
Axis I Psychopathology and the Perpetration of Intimate Partner Violence
Authors: Crane Cory A. , Hawes Samuel W. , Devine Susan , Easton Caroline J.
Published: July 2013

Objectives

Initial evidence suggests that individuals with specific psychiatric conditions may perpetrate intimate partner violence (IPV) at greater frequency than nondiagnosed comparison samples. The present investigation examined the relationship between IPV and specific clinical diagnoses.

Method

The current investigation utilized data provided by 190 (34% female) adult offenders during court‐mandated substance use evaluations to investigate the incidence of past‐year IPV among samples of dually diagnosed (bipolar, posttraumatic stress disorder [PTSD], and attention deficit‐hyperactivity disorder [ADHD]) clients relative to 3 comparison samples matched on substance use and sociodemographic variables.

Results

Bipolar and PTSD diagnosed participants were more likely to perpetrate IPV than matched comparison and ADHD participants. Bipolar and PTSD diagnosed participants were equally likely to perpetrate IPV, as were ADHD and matched comparison samples.

Conclusions

The frequency of IPV perpetration among bipolar and PTSD diagnosed clients may complicate interpersonal and relationship functioning. The development of integrated treatments for IPV and underlying psychopathology is recommended.
Modeling the microwave single‐scattering properties of aggregate snowflakes
Authors: Nowell Holly , Liu Guosheng , Honeyager Ryan
Published: July 2013

A new snowflake aggregation model is developed to study single‐scattering properties of aggregate snowflakes. Snowflakes are generated by random aggregation of six‐bullet rosettes constrained by size‐density relationships derived from previous field observations. Due to random generation, aggregates may have the same size or mass, yet different morphology allowing for a study into how shape influences their scattering. Single‐scattering properties of the aggregates were investigated using discrete dipole approximation (DDA) at 10 frequencies. Results were compared to those of Mie theory for solid and soft spheres (density 10% that of solid ice) and to T‐matrix results for solid and soft spheroidal cases with aspect ratios of 0.8. Above size parameter 0.75, neither the solid nor the soft sphere and spheroidal approximations accurately represented the DDA results for aggregates. Asymmetry and the normalized scattering and backscattering cross sections of the aggregates fell between the soft and solid spherical and spheroidal approximations. This implies that evaluating snow scattering properties using realistic shapes, such as the aggregates created in this study, is of paramount importance. Concerning the morphology of the aggregate snowflakes created in this study, the dependence of their single‐scattering properties on each aggregate's detailed structure seemed of secondary importance. Using normalized standard deviation as a measure of relative uncertainty, it is found that the relative uncertainty in backscattering arising from the different morphologies caused by random aggregation is typically ~15% for individual particles and ~18% when integrated over size distributions. Relative uncertainties for other single‐scattering parameters are less.
Two‐dimensional numerical modeling of the Rheasilvia impact formation
Authors: Ivanov B. A. , Melosh H. J.
Published: July 2013

We numerically modeled the formation of Rheasilvia crater, an enormous impact basin centered on asteroid 4 Vesta's south pole. Using a trial and error method, our models were adjusted to produce the best possible fit to Rheasilvia's size and shape, as observed during the Vesta orbital stage of the Dawn mission. The final model yields estimates of the shock wave decay, escaped material volume, depth of excavation, and other relevant characteristics, to the extent allowed by the two‐dimensional (axially symmetric) approximation of the Simplified Arbitrary Lagrangian Eulerian hydrocode. Our model results permit interpretation of the Dawn data on Vesta's shape, topographic crater profiles, and the origin of the Vestoid asteroid family as escaped ejecta from the Rheasilvia crater.
The dramatic climate warming in the Qaidam Basin, northeastern Tibetan Plateau, during 1961–2010
Authors: Wang Xuejia , Yang Meixue , Liang Xiaowen , Pang Guojin , Wan Guoning , Chen Xiaolei , Luo Xiaoqing
Published: July 2013

On the basis of meteorological station records during 1961–2010, we investigate the variations of temperature and precipitation in the Qaidam Basin. Results show that climate warming is significant in the region of Qaidam Basin over the past 50 years, with an average warming rate of 0.53 °C 10a−1. The largest and smallest warming rate happened at Mangya station (0.89 °C 10a−1) and Lenghu station (0.24 °C 10a−1), respectively. Seasonal warming was greatest in winter at eight meteorological stations, ranging from 0.43 °C 10a−1 (Lenghu station) to 1.01 °C 10a−1 (Delingha station). Since 1961, the annual precipitation has increased with a rate of 7.38 mm 10a−1. Seasonal precipitation mainly increased in summer (4.02 mm 10a−1). The maximum precipitation increase occurred at Delingha station (25.09 mm 10a−1) and the minimum at Lenghu station (0.10 mm 10a−1). The elevation dependency of warming trends is unremarkable because most of the stations are located at lower altitudes. It is suggested that sunshine duration is related to the tendencies of temperature increase at different stations. Pollution emissions from industrial processes (i.e. brown clouds) and urbanization are the main factors contributing to the warming climate. Furthermore, the predominant weakening of zonal wind speed over the Tibetan Plateau resulted from the global warming also contributes to the climate warming in the Qaidam Basin. Consequently, the warming rate in the Qaidam Basin is much higher than in other regions over the Tibetan Plateau. The Qaidam Basin is thus considered to be the most susceptible region with the most significant warming in the Tibetan Plateau.
Polymerization Mechanism of MMA in the Presence of 1,1‐Diphenylethylene
Authors: Zhao Minjian , Chen Dong , Shi Yan , Yang Wantai , Fu Zhifeng
Published: July 2013

A suitable controlled polymerization mechanism of methyl methacrylate (MMA) in the presence of 1,1‐diphenylethylene (DPE) is presented. The PMMAs with different molecular weight are prepared and the structures of the polymers are characterized by NMR spectroscopy and ESI‐Q‐TOF‐MS. The good agreements between the theoretical and the experimental m/z values of PMMA samples acquired by ESI‐Q‐TOF‐MS provide positive evidence to confirm that only one DPE unit is incorporated into the PMMA macromolecule chains. TEMPO is used as a radical scavenger to capture the active free radicals generated by the scission of the DPE‐containing PMMA polymer. The molecular weight of the DPE‐containing PMMA decreases dramatically after the reaction with TEMPO; meanwhile, the DPE molecule is split from the DPE‐containing PMMA.

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Social Stressors at Work, Sleep Quality and Psychosomatic Health Complaints—A Longitudinal Ambulatory Field Study
Authors: Pereira Diana , Elfering Achim
Published: July 2013

There is increasing evidence that occupational stress increases psychosomatic health complaints in the long run. However, the underlying mechanisms are still unclear. The present longitudinal actigraphy field study investigated the role of sleep quality—objectively assessed sleep‐onset latency, sleep efficiency and sleep fragmentation, and subjectively assessed sleep quality—as a mediator in the relationship between stressful work conditions at time 1 and psychosomatic health complaints at time 2. A longitudinal hierarchical regression analysis revealed that social stressors at work were positively related to objectively assessed sleep fragmentation and to psychosomatic health complaints. Moreover, objectively assessed sleep fragmentation mediated the effect of social stressors at work on psychosomatic health complaints. Contrary to our expectations, social stressors at work were not related to other sleep quality parameters (i.e. sleep‐onset latency, sleep efficiency and subjectively assessed sleep quality) during follow‐up. Sleep fragmentation is discussed as an important consequence of social stressors at work that increase the risk of psychosomatic health complaints in the long run. Copyright © 2013 John Wiley & Sons, Ltd.