bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing an adequate university environment to train its users by implementing initiation information literacy programs
Authors: Cheradi Natalia , Habaşescu Silvia
Published: July 2023

Information Literacy is a complex of knowledge, skills and abilities that ensures the optimal implementation of individual information activities aimed at satisfying information needs. The organization of information and knowledge, user training requires the involvement of university libraries and conditions positive perspectives for the librarian profession.
The Development of Legal Word Units in Armenian According to Ghazar Parpetsi’s Work "History of Armenia" (A Synchronic-Diachronic Analysis)
Authors: Karapetyan Sirarpi
Published: July 2023

The lexical stock of any language as its constituent part immediately reflects changes in the social and scientific life of its speakers, i. e. it expresses the changes and evolution of the language itself over time. Every new phenomenon appearing in science, technology, social life, etc. gets its verbal expression at once, which enriches the vocabulary of the language, and legal language is no exception. In its turn, the emergence of new terms happens due to the continuous development and improvement of the vocabulary of the language. These newly coined terms often become established, rooted in the language just as ordinary words and, in this way, make its vocabulary richer.
Ցանկացած լեզվի բառային կազմը՝ որպես դրա անբաժանելի մաս, ուղղակիորեն արտացոլում է լեզվակիրների հասարակական և գիտական կյանքում տեղի ունեցող փոփոխությունները։ Այլ կերպ ասած՝ այն անմիջապես արտացոլում է լեզվի փոփոխությունը և զարգացումը։ Գիտության, տեխնիկայի բնագավառում, հասարակական կյանքում ի հայտ եկած յուրաքանչյուր նոր երևույթ անմիջապես արտահայտվում է լեզվում՝ հարստացնելով դրա բառապաշարը։ Իր հերթին նոր եզրույթների առաջացումը տեղի է ունենում լեզվի բառապաշարի մշտական փոփոխության և հարստացման եղանակով։ Նորաստեղծ այս եզրույթները հաճախ արմատավորվում են լեզվում այնպես, ինչպես սովորական բառերը և դրանով իսկ հարստացնում այն:
Лексический состав любого языка как его составная часть непосредственно отражает изменения, происходящие в общественной и научной жизни носителей данного языка. Каждое новое явление, появляющееся в науке, технике, общественной жизни и т. д., немедленно получает свое словесное выражение, что обогащает словарный запас определенного языка. В свою очередь, появление новых терминов происходит за счет постоянного изменения и обогащения словарного запаса языка. Эти новообразованные термины часто укореняются в языке так же, как и обычные слова, и тем самым обогащают его словарный запас.
The Need for Additions to the “Convention on the Prevention and Punishment of the Crimes of Genocide” Dated December 9, 1948, Taking into Account the Facts ofthe Armenian Genocide
Authors: Hovhannisyan Lilit
Published: July 2023

The Armenian Genocide is one of the heaviest crimes against humanity. It is also the wound of the Armenian people that won’t heal. Along with remembering the pain suffered, the Armenian Genocide obliges Armenian people to fight for the sake of Armenian national security and the restoration of national just rights – compensation for the territorial, material, moral and psychological damages of the Genocide. When the Turkish authorities were planning and implementing the plan to exterminate the Armenian people, the concept of “genocide” did not exist yet. The only section of international law whose norms were corresponding to the actions taken against the Armenians during the Armenian Genocide was the law of war and peace, with the relevant Hague conventions adopted in 1899 and 1907.
Հայերի ցեղասպանությունը մարդկության դեմ ուղղված ամենածանր հանցագործություններից է։ Այն նաև հայ ժողովրդի չսպիացող վերքն է, որը պարտավորեցնում է կրած ցավը հիշելու հետ մեկտեղ՝ պայքարել հանուն մեր ազգային արդար իրավունքների վերականգնման՝ հայ ժողովրդի կրած տարածքային, նյութական, բարոյական, հոգեբանական վնասների հատուցման, հանուն մեր ազգային անվտանգության ապահովման։
Геноцид армян является одним из самых тяжких преступлений против человечества. Он является также незаживающей раной армянского народа, которая обязывает его, не забывая о перенесенной боли, ради обеспечения национальной безопасности бороться за восстановление армянских национальных справедливых прав - возмещение территориального, материального, морального и психологического ущерба, нанесенного армянскому народу в результате геноцида. Когда турецкие власти планировали и осуществляли уничтожение армянского народа, понятия «геноцид» еще не существовало. Единственным разделом международного права, нормы которого соответствовали действиям, предпринятым против армян во время Геноцида,было право войны и мира с соответствующими Гаагскими конвенциями, принятыми в 1899 и 1907 годах.
Audyty architektoniczne jako narzędzie kreowania dostępności obiektów uczelnina przykładzie wybranych domów studenckich Politechniki Łódzkiej
Authors: Borowczyk Joanna , Przewłocka-Sionek Renata
Published: July 2023

Autorki podjęły temat dotyczący badania dostępności architektonicznej wybranych domów studenckich Politechniki Łódzkiej w celu oceny skuteczności powszechnych narzędzi audytowych opartych na ewaluacji w formie kwestionariusza. W artykule starano się odpowiedzieć na pytanie, czy wysiłek podejmowany w ramach projektów grantowych finansowanych z Europejskiego Funduszu Społecznego, wkładanyw ulepszenie dotychczasowej metodyki przeprowadzania audytów architektonicznych, służy osiągnięciu głębszego, wieloaspektowego wglądu w stan dostępności obiektów pełniących istotną funkcję w strukturze organizacyjnej i funkcjonalnej społeczności akademickiej. Celem badania jest zarówno określenie realnej dynamiki postępów w zakresie dostępności domów studenckich, jaki wypracowanie propozycji narzędzi służących jej przyśpieszeniu.PRAWIDŁOWY SPOSÓB CYTOWANIA: Borowczyk Joanna, Przewłocka-Sionek Renata, 2023, Audyty architektoniczne jako narzędzie kreowania dostępności obiektów uczelni na przykładzie wybranych domów studenckich Politechniki Łódzkiej, „Builder” 8 (313). DOI: 10.5604/01.3001.0053.7514
UMRÂN TEORİSİ BAĞLAMINDA OĞUZ KAĞAN DESTANI VE DEDE KORKUT HİKÂYELERİ
Authors: KOÇAK Alirıza
Published: July 2023

Türk halk edebiyatının anonim ürünleri Türk kültürünün ve Türk halkının hayata dair meseleler karşısında takındığı ortak tavrı tespit etmek açısından kıymetli bir kaynaktır. Bu bilgi kaynağının derlenmesi kadar farklı teorilerle ince-lenmesi de önem taşımaktadır. Gerçekleştirilen her bir inceleme halk edebiyatı ürünlerinde saklı bulunan hususiyetle-rin ortaya çıkarılması için önemli bir adımdır. Bu çalışma ile Türk tarihi ve kültürü için önemli birer vesika olan Oğuz Kağan Destanı ve Dede Korkut Hikayeleri İbn Haldun’un umrân teorisi ekseninde ele alınacaktır. Umran teorisi, bir insan topluluğun nasıl millete dönüştüğü ve devlet yapısı içerisinde egemenlik unsurlarının nasıl gelişip zayıfladığına dair görüşler içermektedir. Söz konusu çalışmada metinler, bir toplumun devletleşme ve medenileşme sürecinde İbn Haldun’a göre geçtiği merhaleler açısından ele alınmış ve metinlerden örneklerle açıklamalar yapılmıştır. Çalışma sonucunda İbn Haldun’a ait kuramların, Türk kütür ve devlet yapısı için de geçerli olduğu, destan devrinden halk hikâyesi devrine geçen toplumun medenî şartlarının da bu teori ekseninde gözlemlenebilecek değişimlerle metinlere yansıdığı görülmüştür.
ŞAHZADE BEHRAM VE MELİKE DİLRİZ ANLATISI ÖRNEKLEMİNDE UY-GUR SÖZLÜ KÜLTÜRÜNDE BİR ÂŞIK TİPİ OLARAK HIZIR
Authors: ÇAM Esra
Published: July 2023

Halk anlatıları kültürel belleğin önemli bir bileşenidir. Geçmişten gelen bilgiler, deneyimler ve öğretilerin yansıtıldığı ve yaşatıldığı anlatılar, kültürel belleğin devamlığını sağlamak, toplumun kimliğini korumak ve gelecek nesillere ak-tarmak fonksiyonuna sahiptir. Halk anlatılarından biri olan Türk halk hikâyeleri de yerleşik yaşama geçişin mahsulü olup Türklerin bu dönemi hakkında pek çok kodlar barındıran bir türdür. Halk hikâyeleri toplumsal yaşamın ve ça-tışmaların içe dönük olması bir yana özellikle yerleşik yaşamın etkisiyle birlikte aşk konularıyla ön plana çıkmaktadır. Uygurlar, erken dönemlerden itibaren tarih sahnesinde varlığını sürdüren yerleşik yaşama erken geçmiş köklü bir Türk boyudur. Bu köklü geçmişlerini yaratmış oldukları sözlü ve yazılı anlatılara da görmek mümkündür. Bu çalışma-ya konu olan “Şahzade Behram ve Melike Dilriz” adlı anlatıda da buna bir örnektir. Anlatıda, kadın kahramanın eşte aradığı özellikler, erkek kahramanları tâbi tuttuğu yarışlar yerleşik yaşamın kültürel kodlarını taşıyan motifler arasın-dadır. Bu çerçevede şekillenen ve bu çalışmanın merkezinde yer alan Hızır tipi de Uygur Türklerinin kolektif hafızası-nın ürünü olup gelenekteki Türk Hızır inancıyla ortak ve ayrılan yönleri bulunmaktadır. Bu makalede Uygur Türkleri-nin inanç yapısındaki ve kültüründeki Hızır tipinin yapısı ve özellikleri tespit edilerek incelenmiştir
Factores de riesgo que influyen en la presencia de anosmia y ageusia en pacientes Sars-Cov2 Positivos
Authors: Salas Torres María Paula , Varela Rojas Daniel Alonso , Serrano Román Daniel
Published: July 2023

En los últimos meses el mundo ha enfrentado cambios drásticos debido a la pandemia por el SARS-CoV2. La complejidad del virus ha llevado a que, para el personal de salud, sea difícil identificar la gran variedad de síntomas que puede conllevar el COVID-19 y de esta forma, muchos diagnósticos pueden atrasarse y no realizarse en el periodo óptimo. Gracias a la constante investigación científica se ha descrito una sintomatología muy variable, que va desde lo más frecuente, que incluye síntomas como la fiebre, dolor de garganta, tos seca y dificultad respiratoria, hasta síntomas no tan comunes como la diarrea, malestar estomacal, anosmia, hiposmia, entre otros. Un aspecto que ha llamado la atención del personal de salud, es como la presencia de la anosmia y disgeusia ha sufrido un aumento en los últimos meses y como se ha establecido una estrecha relación con el SARS-CoV2 como un síntoma precoz, que aparece incluso antes que la fiebre. Esto puede guiar al personal de salud a realizar un diagnóstico en el momento preciso para poder rastrear cadenas de contagio y así detenerlas. Claramente, también tiene una gran importancia en como la atención médica podría influir de manera positiva en el estado del paciente.
A review on orodispersible drug delivery system
Authors: Iqbal Sonia , Hanan Hanasul , Maqbool Afshan , Munawar Nasra
Published: July 2023

The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary secretion in the oral mucosa and released the drug fast approximately within 3 mins. ODFs are of different types, like sustained or controlled release, oral patches and fast dissolving films. They can be manufactured using a variety of method including solvent and semi solid casting, hot melt and solid dispersion extrusion, spray drying and rolling. Among them solvent casting method is the most employed method. ODFs comprises of active ingredient, polymer, plasticizer and additives like surfactants, sweetening and coloring agents. ODFs preparation requires hydrophilic polymer which provides quick dissolution in the oral cavity. Hydrophilic polymer act as base for ODFs formulation as they impart mouth feel and mechanical properties of the ODFs also dependent of polymer type. Oral thin-film provide fast drug dissolution precise dosage in a portable, safe, and handy manner that doesn't required water or any special equipment. This review article comprises of different methods for ODFs preparations, ODFs ingredients, ODFs benefits and drawbacks and their packaging.
Electrochemical Corrosion Study of Cold-Rolled AA8015-Alloy Processed by Reversing Cold Rolling Mill at Varying Surface Roughness
Authors: Olaogun Olayinka , Titilayo Akinlabi Esther , Samuel Abima Cynthia
Published: July 2023

AA8015-alloy is a general-purpose aluminium alloy having a wide range of applications. Electrochemical corrosion testing of cold-rolled AA8015-alloy processed by reversing cold-rolling mill at different surface roughness in natural seawater were investigated. The AA8015-alloy utilised in this study was cold-rolled in a reversible Achenbach cold-rolling mill in four number of passes to a gauge thickness of 1.2 mm. This industrial cold rolling process was achieved at Tower Aluminium Rolling Mill, Sango-Ota, Nigeria. The different surface roughness’s each with three cold mounted samples, 1.54 μm, 0.83 μm, 0.18 μm and 0.04 μm were achieved on automated polishing machine using 320-grit, 800-grit, 1200-grit and diamond abrasive MD-Mol respectively. Electrochemical corrosion experiments were conducted on the samples in natural seawater using a computer-controlled potentiostat in an open polarisation cell set-up at room-temperature. The corrosion behaviour on surface morphologies of the samples was observed by high-mega-pixel camera and scanning electron microscope. Findings reveal asymmetric polarisation curves, and the polarisation resistance increases as the surface roughness decreases. Consequently, corrosion-rate reduces as the surface get smoother and EDS elemental analysis shows the existence of insoluble sulphate and chloride complexes formed on the surfaces. Conclusively, surface roughness affects the corrosion resistance of cold-rolled AA8015-alloy in natural seawater.
Perspective Chapter: Secondary Metabolites of Entomopathogens as Biotechnological Tools for the Biological Control of Agricultural Insect Pests
Authors: Rodríguez-Romero Hugo , Rodríguez-Peláez Laura , Reyes-Castro Adriana , Tlakaele Notario-Rendón Orlando , González-Peréz Manuel , Reza-Salgado Juventino , Antonio Rodríguez-Salazar Pedro , Antonio Salazar-Magallón Jesús
Published: July 2023

In recent years, the irrational application of chemical insecticides has caused the appearance of pest insect populations that are resistant to the active principles of commercial insecticides. In addition, these chemical compounds cause significant damage to the environment and to the people who apply them. The use of secondary metabolites produced by entomopathogenic microorganisms is a viable alternative that could mitigate the damage caused by chemical insecticides. Actually, the secondary metabolites of entomopathogens microorganisms have been studied; however, there are few reports on their massive production and their direct application as biological control agents. The aim of this book chapter is to describe, in a very general way, some of the secondary metabolites produced by entomopathogenic microorganisms, their potential application as bioinsecticides as well as their mass production.
A condição climática de origem das árvores afeta a incidência de fungos e a qualidade de sementes de Pityrocarpa moniliformis?
Authors: Felix Francival Cardoso , Demartelaere Andréa Celina Ferreira , Medeiros Josenilda Aprígio Dantas de , Pacheco Mauro Vasconcelos , Pereira Márcio Dias
Published: July 2023

A presença de fungos potencialmente prejudiciais durante a maturação e dispersão das sementes tem relação com fatores bióticos e abióticos. Esses microrganismos podem causar perda da qualidade fisiológica de sementes em condições climáticas desfavoráveis. Nesta pesquisa, levantou-se a hipótese de que a qualidade sanitária das sementes produzidas é afetada pela árvore e condição climática de origem. Assim, objetivou-se avaliar a incidência de fungos e a qualidade de sementes de Pityrocarpa moniliformis provenientes de diferentes árvores e duas condições climáticas (Aw: tropical chuvoso; e BSh: semiárido quente). Coletaram-se sementes de 28 árvores, avaliando-se separadamente a qualidade fisiológica e sanitária das sementes produzidas em cada árvore. Diferentes árvores originaram sementes com diferenças na qualidade fisiológica e incidência de fungos. A condição climática de origem das árvores afetou a quantidade e a espécie fúngica presente nas sementes produzidas, com incidência predominante dos gêneros Alternaria spp., Aspergillus spp., Botrytis spp., Fusarium spp., Penicillium spp. e Rhyzopus sp, sendo a incidência de Alternaria spp. correlacionada com sementes de baixa qualidade fisiológica. Portanto, conclui-se que árvores de Pityrocarpa moniliformis sob clima tropical chuvoso produzem sementes de qualidade fisiológica e sanitária superior em relação àquelas localizadas em clima semiárido quente.
Topological Shape Optimization Design of the Whole Bead of 265/35R18 Steel-Belted Radial Tire
Authors: Li Yong , Zhang Shuang , Wang Tao , Zhang Kai , Chen Long , Han Shanling
Published: July 2023

The tire bead, as the most important load-bearing component at the bead area, is closely related to the durability of the tire, but its structure is developing slowly. For this reason, the topological whole bead design was proposed, although it performs well, many defects existed due to the design based on traditional experience. Therefore, this paper studies the topology shape optimization algorithm, delves into the main criterion based on von Mises and the interlaminar shear stress, and provides guidance for the structurally optimal design of the 265/35R18 radial tire whole bead. The finite element simulation results show that the von Mises of the inner end of the chafer and the end of the carcass cord are reduced by 14.48% and 24.12%, respectively. The interlaminar shear stress decreased by 28.96% and 49.51%, respectively. The von Mises of chafer and carcass cord decreased by 13.17% to 40.36% and 7.71% to 20.51%, respectively. The optimization design is of great significance to further improve the safety performance of tires.
Young EFL Learners Collaboratively Writing a Dialogue During a Regular Classroom Lesson
Authors: Kos Tomas
Published: July 2023

A growing body of research has explored collaborative writing (CW) among young learners. Nevertheless, studies have mainly focused on tasks such as the dictogloss, which is rather uncommon in regular classroom teaching and has neglected activities that are more common. In addition, research has focused on language-related episodes (LREs) without considering other important episodes including those that involve the teacher. Finally, only one study has explored to what extent the decisions made within LREs transfer into the written product. With these research gaps in mind, the present study examined CW of 12 pairs composed of 10 to 11-year-old learners of English as a foreign language (EFL) who jointly wrote a role-play. Drawing on audio recordings of pair work interactions and documentary analysis of students’ written work, the study has found that in addition to LREs, students frequently engaged in content-related and activity-related episodes with the teacher’s involvement being rather limited. Despite the teacher’s presence, a high proportion of LREs was resolved incorrectly or left unresolved. Nearly all correctly and incorrectly resolved LREs were also incorporated into the jointly written role-play. Students focused predominantly on the language targeted by the activity (lexical phrases) and attended to other language aspects minimally.
Shifting Profile of Africa in Twenty-First Century Black Canadian Writing
Authors: Cuder-Domínguez Pilar
Published: July 2023

The affective link with Africa was visible in those Black Canadian works composed in the late 1980s and early 1990s. In contrast, the profile of Africa has shifted for younger generations of Black diasporan writers in Canada. The purpose of this article is to open up a conversation into how Black Canadian affects, both concerning national identity and homeland connection, seem to have shifted roughly after 2000. In order to do so I analyse The Adventures of the Black Girl in Her Search for God (2017), a reinterpretation by Black Canadian playwright Lisa Codrington of George Bernard Shaw's 1932 short story of the same title. Her play was a milestone in the history of Black Canadian writing, because for the first time a Black Canadian playwright (and a woman, too) was invited to participate in one of Canada's most prestigious and longest-established theatre festivals, the Shaw Festival.
Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis
Authors: Syed Sabriya A. , Shqillo Kristina , Nand Ankita , Zhan Ye , Dekker Job , Imbalzano Anthony N.
Published: July 2023

Protein arginine methyltransferase 5 (Prmt5) is an essential regulator of embryonic development and adult progenitor cell functions. Prmt5 expression is mis-regulated in many cancers, and the development of Prmt5 inhibitors as cancer therapeutics is an active area of research. Prmt5 functions via effects on gene expression, splicing, DNA repair, and other critical cellular processes. We examined whether Prmt5 functions broadly as a genome-wide regulator of gene transcription and higher-order chromatin interactions during the initial stages of adipogenesis using ChIP-Seq, RNA-seq, and Hi-C using 3T3-L1 cells, a frequently utilized model for adipogenesis. We observed robust genome-wide Prmt5 chromatin-binding at the onset of differentiation. Prmt5 localized to transcriptionally active genomic regions, acting as both a positive and a negative regulator. A subset of Prmt5 binding sites co-localized with mediators of chromatin organization at chromatin loop anchors.
Prmt5
knockdown decreased insulation strength at the boundaries of topologically associating domains (TADs) adjacent to sites with Prmt5 and CTCF co-localization. Genes overlapping such weakened TAD boundaries showed transcriptional dysregulation. This study identifies Prmt5 as a broad regulator of gene expression, including regulation of early adipogenic factors, and reveals an unappreciated requirement for Prmt5 in maintaining strong insulation at TAD boundaries and overall chromatin organization.
Effectiveness of a modified Balint group process on empathy and psychological skills employing Kirkpatrick’s evaluation framework
Authors: Antoun Jumana , Khater Beatrice , Itani Hala , Naous Jihane , Romani Maya
Published: July 2023

Background

To evaluate, using Kirkpatrick’s evaluation model, a modified Balint group (BG) by adding 5–10 min at the end of the session, where the facilitators will debrief the residents about critical themes mentioned in the session.

Methods

A quasi-experimental study with a mixed-method design was conducted among family medicine residents over 1 year, using focus groups and validated tools filled by residents and their corresponding patients. The residents’ empathy through self and patient evaluation, psychological skills, and satisfaction with the educational activity were measured.

Results

The focus group revealed that the residents were aware of the change and considered it a closure to the encounter, helping decrease some uncertainty. Most of the residents did not consider the change helpful. Using validated instruments, BG was ineffective at improving the residents’ empathy and psychological skills. There was a statistically significant main effect of time on Psychological Medicine Inventory (PMI) scores, F (1,13) = 7.709, p = 0.016.

Conclusion

Debriefing at the end of BG by the facilitators about key themes may help give the residents closure, decrease the uncertainty, and make them more aware of their feelings. Nevertheless, Balint groups are still not very well accepted by the residents, and they prefer direct feedback and support groups.
In silico identification and in vitro assessment of a potential anti-breast cancer activity of antimicrobial peptide retrieved from the ATMP1 Anabas testudineus fish peptide
Authors: Law Douglas , Abdulkareem Najm Ahmed , Chong Jia Xuan , K’ng Joelene Zi Ying , Amran Mas , Ching Huey Lih , Wong Rui Rui , Leong May Ho , Mahdi Ibrahim Mahmood , Fazry Shazrul
Published: July 2023

A previous study has shown that synthetic antimicrobial peptides (AMPs) derived from Anabas testudineus (ATMP1) could in-vitro inhibit the progression of breast cancer cell lines. In this study, we are interested in studying altered versions of previous synthetic AMPs to gain some insight into the peptides functions. The AMPs were altered and subjected to bioinformatics prediction using four databases (ADP3, CAMP-R3, AMPfun, and ANTICP) to select the highest anticancer activity. The bioinformatics in silico analysis led to the selection of two AMPs, which are ATMP5 (THPPTTTTTTTTTTTYTAAPATTT) and ATMP6 (THPPTTTTTTTTTTTTTAAPARTT). The in silico analysis predicted that ATMP5 and ATMP6 have anticancer activity and lead to cell death. The ATMP5 and ATMP6 were submitted to deep learning databases (ToxIBTL and ToxinPred2) to predict the toxicity of the peptides and to (AllerTOP & AllergenFP) check the allergenicity. The results of databases indicated that AMPs are non-toxic to normal human cells and allergic to human immunoglobulin. The bioinformatics findings led to select the highest active peptide ATMP5, which was synthesised and applied for in-vitro experiments using cytotoxicity assay MTT Assay, apoptosis detection using the Annexin V FTIC-A assay, and gene expression using Apoptosis PCR Array to evaluate the AMP’s anticancer activity. The antimicrobial activity is approved by the disc diffusion method. The in-vitro experiments analysis showed that ATMP5 had the activity to inhibit the growth of the breast cancer cell line (MDA-MB-231) after 48 h and managed to arrest the cell cycle of the MDA-MB-231, apoptosis induction, and overexpression of the p53 by interaction with the related apoptotic genes. This research opened up new opportunities for developing potential and selective anticancer agents relying on antimicrobial peptide properties.
PROPOSTA DE MINIMIZAÇÃO DE CUSTOS DE ESTOQUE APLICADO EM UMA EMPRESA VAREJISTA DE COSMÉTICOS NO MUNICÍPIO DE REDENÇÃO – PA
Authors: Picanço Ailson Renan Santos , Da Costa Esther Corrêa , Da Silva Vitória Soares
Published: July 2023

O gerenciamento de estoque e de materiais são cruciais para a capacidade de uma empresa de controlar e regular a quantidade de seus produtos. Com o auxílio da gestão da qualidade e das ferramentas disponíveis, é possível propor soluções para problemas frequentemente encontrados e que interferem no bom andamento dos processos de trabalho. Portanto, este trabalho tem como objetivo realizar um estudo de caso em uma empresa de pequeno porte (EPP) de cosméticos em Redenção - PA, a fim de propor um modelo de minimização de custos de estoque. A metodologia utilizada consiste numa entrevista estruturada com análises qualitativas e quantitativas, de natureza exploratória. A avaliação terá por base os dados recolhidos no ano de 2022 relativos à entrada de produtos em estoque e à disposição física do espaço. O diagnóstico obtido por meio do diagrama de Ishikawa identificou problemas como desorganização do layout e uso incorreto do software de gestão. Com base nisso, foi desenvolvido um plano de ação para organizar e melhorar os processos e o layout da armazenagem, garantindo qualidade e eficiência no atendimento dos pedidos dos clientes e agilizando os processos e atividades gerais.
Succinate oxidation rescues mitochondrial ATP synthesis at high temperature in Drosophila melanogaster
Authors: Roussel Damien , Janillon Sonia , Teulier Loïc , Pichaud Nicolas
Published: July 2023

Decreased NADH‐induced and increased reduced FADH2‐induced respiration rates at high temperatures are associated with thermal tolerance in Drosophila. Here, we determined whether this change was associated with adjustments of adenosine triphosphate (ATP) production rate and coupling efficiency (ATP/O) in Drosophila melanogaster. We show that decreased pyruvate + malate oxidation at 35°C is associated with a collapse of ATP synthesis and a drop in ATP/O ratio. However, adding succinate triggered a full compensation of both oxygen consumption and ATP synthesis rates at this high temperature. Addition of glycerol‐3‐phosphate (G3P) led to a huge increase in respiration with no further advantage in terms of ATP production. We conclude that succinate is the only alternative substrate able to compensate both oxygen consumption and ATP production rates during oxidative phosphorylation at high temperature, which has important implications for thermal adaptation.
Rational Design of a Chemical Bath Deposition Based Tin Oxide Electron‐Transport Layer for Perovskite Photovoltaics
Authors: Lu Yongli , Shih Meng‐Chen , Tan Shaun , Grotevent Matthias J. , Wang Lili , Zhu Hua , Zhang Ruiqi , Lee Joo‐Hong , Lee Jin‐Wook , Bulović Vladimir , Bawendi Moungi. G.
Published: July 2023

Chemical bath deposition (CBD) is widely used to deposit tin oxide (SnOx) as an electron‐transport layer in perovskite solar cells (PSCs). The conventional recipe uses thioglycolic acid (TGA) to facilitate attachments of SnOx particles onto the substrate. However, nonvolatile TGA is reported to harm the operational stability of PSCs. In this work, a volatile oxalic acid (OA) is introduced as an alternative to TGA. OA, a dicarboxylic acid, functions as a chemical linker for the nucleation and attachment of particles to the substrate in the chemical bath. Moreover, OA can be readily removed through thermal annealing followed by a mild H2O2 treatment, as shown by FTIR measurements. Synergistically, the mild H2O2 treatment selectively oxidizes the surface of the SnOx layer, minimizing nonradiative interface carrier recombination. EELS (electron‐energy‐loss spectroscopy) confirms that the SnOx surface is dominated by Sn4+, while the bulk is a mixture of Sn2+ and Sn4+. This rational design of a CBD SnOx layer leads to devices with T85 ≈1500 h, a significant improvement over the TGA‐based device with T80 ≈250 h. The champion device reached a power conversion efficiency of 24.6%. This work offers a rationale for optimizing the complex parameter space of CBD SnOx to achieve efficient and stable PSCs.
Quetiapine‐induced chest wall edema with the swellings of face and extremities in a young hospitalized patient: A case report
Authors: Elyasi Forouzan , Heydari Fatemeh , Haddadi Kaveh
Published: July 2023

Key Clinical Message

Quetiapine can lead to the face, extremity and particularly chest wall edema in hospitalized patients in the supine position.

Quetiapine (QTP) is known as an atypical antipsychotic agent with some adverse effects, such as edema. However, along this line, peripheral edema is not a life‐threatening episode, but it is an important side effect affecting medical compliance. Therefore, QTP‐induced chest wall edema with the swellings of the face and the extremities is very rare. This report is about a young man who was admitted in the intensive care unit with multiple trauma (MT). On account of his delirious state, QTP was started at 25 mg and then increased to 75 mg, three times a day. The patient developed swelling of the face, the upper and lower limbs, and the chest wall. After stopping the QTP use, his edema went down. Although there is still speculation about the possible mechanisms of antipsychotic‐induced edema, some studies have pointed to the relationship between dopaminergic antagonism and peripheral edema. Therefore, it is very important to pay close attention to this side effect.
Anti‐TNFα induced lupus due to infliximab therapy in a patient with concurrent Crohn's disease
Authors: Sharma Akanksha , Ahmed Taha , Mehta Aashna , Birnbaum Julius , Shrestha Abhigan Babu
Published: July 2023

Anti‐TNFα inhibitor‐induced Lupus (ATIL) is a rare syndrome characterized by a wide array of symptoms ranging from skin manifestations to organ‐specific symptoms such as pleural effusions, pericardial effusions, hepatotoxicity, etc. Infliximab is implicated in most cases, and ATIL usually develops between the first month and 4 years of infliximab application. In this report, we present an interesting case of ATIL that developed rather gradually upon anti‐TNFa used to treat Crohn's disease. The patient presented with oral ulcers, photosensitive rash, diffuse alopecia, inflammation of the hands, and pleuritic chest pain. Comprehensive serological testing revealed the presence of antinuclear antibodies and anti‐DNA antibodies. During the evaluation, the patient developed headaches, followed by a brain MRI that suggested nonspecific white matter lesions. Given the chronic development of symptoms, invasive examinations such as an arteriogram were performed to exclude CNS vasculitis, which showed no evidence of the vasculitis. Therefore, in the absence of any clear radiographical signs of vasculitis, patients should not undergo invasive studies, including an angiogram. The CNS angiogram can be associated with several side effects, including damage to the blood vessel, bruising or bleeding at the puncture site, and infection, which can further aggravate ATIL. Although rare, ATIL should always be considered while evaluating a patient with suggestive symptoms on infliximab therapy. Further research on identifying the variety of clinical presentations of ATIL and the underlying pathophysiology can help improve health policy and clinical practice by reducing unnecessary examination and allowing early management and better‐quality care.
Investigations on the in vitro and in vivo metabolic fate of the new synthetic opioid desmethylmoramide using HPLC–HRMS/MS for toxicological screening purposes
Authors: Manier Sascha K. , Valdiviezo Johannes Angert , Eckstein Niels , Meyer Markus R.
Published: July 2023

New synthetic opioids are an increasing challenge for clinical and forensic toxicologists that developed over the recent years. Desmethylmoramide (DMM), a structural analogue of methadone, is one of the most recent appearances on the drug market. This study investigated its metabolic fate in rat and pooled human liver S9 fraction (pHLS9) to allow the identification of suitable urinary screening targets beyond the parent compound. The analysis of rat urine after the administration of DMM revealed five metabolites, which were the result of pyrrolidine ring or morpholine ring hydroxylation and combinations of them. Additionally, an N′,N‐bisdesalkyl metabolite was formed. Incubations of DMM using pHLS9 revealed a pyrrolidine hydroxy metabolite, as well as an N‐oxide. No Phase II metabolites were detected in either rat urine or incubations using pHLS9. The metabolism of DMM did in part comply with that of its archetype dextromoramide (DXM). Although morpholine ring hydroxylation and N‐oxidation were described for DXM and detected for DMM, phenyl ring hydroxylation was not found for DMM but described for DXM. An analysis of 24 h pooled rat urine samples after DMM administration identified the hydroxy and dihydroxy metabolite as the most abundant excretion products, and they may, thus, serve as screening targets, as the parent compound was barely detectable.
Color Doppler, HDlive, and HDlive Silhouette features of an umbilical cord cyst before 11 weeks of gestation: Diagnostic value
Authors: Hata Toshiyuki , Konishi Miyu , Kawahara Tomomi , Miyagi Yasunari , Miyake Takahito
Published: July 2023

Objective

We describe transvaginal color Doppler, HDlive, and HDlive Silhouette features of an umbilical cord cyst (UCC) before 11 weeks of gestation.

Methods

In this cohort study, 135 transvaginal dating scans were performed at 7 to 10 + 6 weeks of gestation, and 17 UCCs were identified (12.6%). UCC was evaluated using color Doppler, HDlive, and HDlive Silhouette. The clinical characteristics, pregnancy courses, and outcomes were also investigated.

Results

UCC location was on the fetal side in six cases, at the free loop in 10 cases, and on the placental side in one case. There were seven single and 10 multiple cysts. Cyst diameters ranged from 3.3 to 11.3 mm (mean, 5.6; standard deviation, ±2.1). Blood flow inside the cyst was noted in three cases (17.6%). HDlive clearly showed the spatial relationships among UCC, the umbilical cord, midgut herniation, yolk sac, and embryo. Location of UCC could be clearly identified with HDlive. HDlive Silhouette showed central cysts inside UCCs in seven cases (41.2%). HDlive Silhouette also clearly demonstrated the sac of midgut herniation in the umbilical cord in 12 cases (70.6%). All UCCs resolved before 15 weeks (mean, 11.1 weeks; standard deviation, ±1.5). All fetuses with UCCs showed good neonatal outcomes.

Conclusion

The incidence of UCC was high compared with that in previous reports. Color Doppler, HDlive, and HDlive Silhouette may provide information on the nature and origin of UCCs before 11 weeks of gestation. UCC before 11 weeks of gestation may be a common, transient, and benign finding.
Development and validation of a nomogram for predicting the risk of vasovagal reactions after plasma donation
Authors: Zhao Peizhe , Dong Demei , Dong Rong , Zhou Yuan , Hong Yan , Xiao Guanglin , Li Zhiye , Su Xuelin , Zheng Xingyou , Liu Xia , Zhang Demei , Li Ling , Liu Zhong
Published: July 2023

Background and Objectives

Vasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrence of VVRs after plasma donation and to construct a nomogram to identify individuals at risk for VVRs to improve the safety of plasma donors.

Materials and Methods

We collected the donation data from July 2019 to June 2020 from a plasma center in Sichuan, China, to explore the independent risk factors for vasovagal reactions. From these data, we constructed and validated a predictive model for vasovagal reactions.

Results

VVRs after plasma donation occurred 737 times in 120 448 plasma donations (0.66%). Gender, season, donor status, weight, pulse, duration of donation, and cycle were independent risk factors for VVRs (P< 0.05). The concordance index (C‐index) of a logistic model in the derivation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.795. The C‐index of a logistic model in the validation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.224. The calibration curve showed that the predicted results were in good agreement with the actual observed results.

Conclusion

This study preliminarily constructed and verified a prediction model for VVRs after plasma donation. The model nomogram is practical and can identify high‐risk donors.
State‐of‐the‐art and challenges in the analysis of renewable gases
Authors: Legendre Agathe , Jores Clément De Saint , Dugay José , Cuccia Lorena , Ballestas Castro Dairo , Thiebaut Didier , Vial Jérôme
Published: July 2023

The development of renewable and low‐carbon gases for injection into the gas grid obtained by different processes such as anaerobic digestion, pyrogasification, hydrothermal gasification, and methanation, followed by upgrading steps, increases the demand for analysis and characterization in order to fully manage their integration into the gas value chain. If the analysis of the main compounds (methane, carbon dioxide, hydrogen, and carbon monoxide) is well described, the analysis of impurities in renewable gases remains more challenging due to their various natures and quantities.

After a brief description of renewable and low‐carbon methane production processes, the review focuses on the methods used for the analysis of the different compounds in renewable gases, from the main ones to impurities at ppbvlevels. Gas chromatography (GC), coupled with different detectors, is the preferred technique, enabling the analysis and quantification of siloxanes, terpenes, oxygenates, and sulfur compounds. Recently, comprehensive two‐dimensional GC has been applied to renewable gases, increasing the number of compounds detected. Non‐chromatographic techniques are also reviewed. As sampling is of major importance in the search for reliable analyses, a whole section is devoted to this aspect. Among the available methods, pre‐concentration on adsorbent tubes emerges as the most relevant solution.
Advances in Targeting Drug Biological Carriers for Enhancing Tumor Therapy Efficacy
Authors: Xia Donglin , Li Jia , Feng Lingzi , Gao Ziqing , Liu Jun , Wang Xiangqian , Hu Yong
Published: July 2023

Chemotherapy drugs continue to be the main component of oncology treatment research and have been proven to be the main treatment modality in tumor therapy. However, the poor delivery efficiency of cancer therapeutic drugs and their potential off‐target toxicity significantly limit their effectiveness and extensive application. The recent integration of biological carriers and functional agents is expected to camouflage synthetic biomimetic nanoparticles for targeted delivery. The promising candidates, including but not limited to red blood cells and their membranes, platelets, tumor cell membrane, bacteria, immune cell membrane, and hybrid membrane are typical representatives of biological carriers because of their excellent biocompatibility and biodegradability. Biological carriers are widely used to deliver chemotherapy drugs to improve the effectiveness of drug delivery and therapeutic efficacy in vivo, and tremendous progress is made in this field. This review summarizes recent developments in biological vectors as targeted drug delivery systems based on microenvironmental stimuli‐responsive release, thus highlighting the potential applications of target drug biological carriers. The review also discusses the possibility of clinical translation, as well as the exploitation trend of these target drug biological carriers.
Outer membrane β‐barrel structure prediction through the lens ofAlphaFold2
Authors: Topitsch Annika , Schwede Torsten , Pereira Joana
Published: July 2023

Most proteins found in the outer membrane of gram‐negative bacteria share a common domain: the transmembrane β‐barrel. These outer membrane β‐barrels (OMBBs) occur in multiple sizes and different families with a wide range of functions evolved independently by amplification from a pool of homologous ancestral ββ‐hairpins. This is part of the reason why predicting their three‐dimensional (3D) structure, especially by homology modeling, is a major challenge. Recently, DeepMind's AlphaFold v2 (AF2) became the first structure prediction method to reach close‐to‐experimental atomic accuracy in CASP even for difficult targets. However, membrane proteins, especially OMBBs, were not abundant during their training, raising the question of how accurate the predictions are for these families. In this study, we assessed the performance of AF2 in the prediction of OMBBs and OMBB‐like folds of various topologies using an in‐house‐developed tool for the analysis of OMBB 3D structures, andbarrOs. In agreement with previous studies on other membrane protein classes, our results indicate that AF2 predicts transmembrane β‐barrel structures at high accuracy independently of the use of templates, even for novel topologies absent from the training set. These results provide confidence on the models generated by AF2 and open the door to the structural elucidation of novel transmembrane β‐barrel topologies identified in high‐throughput OMBB annotation studies or designed de novo.
Women, power, and rape culture: The politics & policy of underrepresentation. By BonnieStabile, Aubrey LeighGrant, Bloomsbury Publishing. 2023. eISBN‐13: 9781440876981
Authors: Bullock Carla G.
Published: July 2023

This book review is an analysis of how the author’s have connected the Trump presidency to the continued and rampant abuse towards women in the United States. Bonnie Stabile and Aubrey Leigh Grant have detailed their research of sexual harassment and assault long being an issue in the American society, however it has been echoed by many politicians whom have the power to impact our rights with their beliefs. This review breaks down the main points detailed in Women, Power, and Rape Culture: The Politics & Policy of Underrepresentation, and presents an understanding of abuse of power on a government level and the maltreatment women face because of this.
A Planning Tool for Improving Interactive Read‐Alouds: Why and How
Authors: Venegas Elena M. , Guanzon Angelica
Published: July 2023

Interactive read‐alouds are versatile in that teachers can teach an array of literacy skills through this instructional strategy. However, our observations of six primary grade teachers and prior research revealed that teachers' implementation of interactive read‐alouds varies. Without the necessary planning and preparation for interactive read‐alouds, the richness of this instructional strategy is limited. In this article, we present a planning tool for interactive read‐alouds that teachers can readily adapt for use in their classrooms. We also offer three recommendations. Together the planning tool and recommendations are specific enough to provide guidance yet flexible enough for teachers to modify to meet the learning goals of their specific students. Improving this instructional practice will ensure that all students benefit from the interactive read‐alouds and grow in their phonological and phonemic awareness, phonics, vocabulary, and comprehension.
ESG ratings explainability through machine learning techniques
Authors: Del Vitto Alessandro , Marazzina Daniele , Stocco Davide
Published: July 2023

Environmental, Social, and Governance (ESG) scores are quantitative assessments of companies’ commitment to sustainability that have become extremely popular tools in the financial industry. However, transparency in the ESG assessment process is still far from being achieved. In fact there is no full disclosure on how the ratings are computed. As a matter of fact, rating agencies determine ESG ratings (as a function of the E, S and G scores) through proprietary models which public knowledge is limited to what the data provider effectively chooses to disclose, that, in many cases, is restricted only to the main ideas and essential principles of the procedure. The goal of this work is to exploit machine learning techniques to shed light on the ESG ratings issuance process. In particular, we focus on the Refinitiv data provider, widely used both from practitioners and from academics, and we consider white-box and black-box mathematical models to reconstruct the E, S, and G ratings’ assessment model. The results show that it is possible to replicate the underlying assessment process with a satisfying level of accuracy, shedding light on the proprietary models employed by the data provider. However, there is evidence of persisting unlearnable noise that even more complex models cannot eliminate. Finally, we consider some interpretability instruments to identify the most important factors explaining the ESG ratings.