bluuebunny/crossref_metadata_2025 huggingface dataset:
Usage of Laryngeal Mask Airway Devices in Veterinary Medicine
Authors: Vidricková Petra , Boldižár Martin
Published: October 2020

Providing a secure airway management during general anesthesia could be problematic in some medical cases, especially when there is a risk of regurgitation and aspiration of the gastric content due to increased intragastric pressure. The current study aimed to test the applicability of two types of LMA in several animal species and to compare its effectiveness to the endotracheal intubation method in securing sealed airway respiration as an alternative to using endotracheal tubes. The study was conducted in dogs (n=33), cats (n=9), swine (n=9), rabbits (n=5), sheep (n=7) and roe deer (n=1). One or both types of laryngeal masks were used for each animal species: LMA Classic™-cLMA and LMA ProSeal™-PLMA. The assessment of each laryngeal mask was performed by determining the insertion technique, the possibilities of first-attempt insertion and malposition, the compliance with various animal species, ventilation time, cuff pressure, and sealing capacity. The highest LMA size compatility in dogs (23,87±14,30 kg) was size-3 in six and size-4 in forteen subjects; In swine (43,22±12,32 kg), size-4; In rabbits (3,84±0,36 kg) size-1; and in sheep (48,29±4,65 kg) size-3 and size-4. Ventilation time was highest in swine and roe deer (121,11±42,85 min and 300,00 min, respectively) and lowest in cat (28,33±16,96 min). First-attempt LMA insertion success was lowest in rabbits (60%), and highest in sheep and roe deer (100%). Malposition was with highest rate in rabbits (40%) and lowest in cat, sheep and roe deer (0%). Gastric reflux was most frequently observed in sheep (71,4%) and roe deer (100%). The usage of LMA in the veterinary anesthetic practice significantly improves airway management in animals during general anesthesia. The inflated LMA cuff does not prevent its disposition. Therefore, both the drain and respiratory tubes must be fixed. The usage of LMA in rabbits was associated with higher incidence of malposition and other complications. Our findings suggest that LMA designed for humans can be used for airway management in veterinary medicine.
Modification of the Standard 7-Day Ovsynch Protocol to Increase the Luteolytic and Synchronization Risks in Dairy Cows
Authors: Atanasov Branko , Adamov Nikola , Celeska Irena , Ilievska Ksenija , Angjelovski Branko , Trbogazov Zvonko , Davkov Filip , Dovenski Toni , Opsomer Geert , Stevenson Jeffrey
Published: October 2020

We hypothesized that a single dose of PGF2α belatedly injected on day 8 after GnRH-1 in cows receiving a 7-day Ovsynch-56 protocol (GnRH – 7 days – PGF2α – 56h – GnRH – 16h – timed AI) will increase the proportion of cows with complete luteolysis. At day 35±3 postpartum, 70 lactating Holstein cows from one herd were scored for body condition and pre-synchronized with PGF2α and GnRH (3 days apart) and 7 days later submitted to an Ovsynch-56 protocol for first AI after random assignment to two treatments: (1) OV-7 (n=35) with an injection of PGF2α either on day 7; or (2) OV-8 (n=35) on day 8 after G1, respectively. Blood was collected before the first PGF2α, at day 7 and day 8 in OV-7 and OV-8, respectively, at AI and at 7 days after AI to assess progesterone concentration. Ten cows were classified as acyclic and were excluded from the analysis resulting in 60 cows (OV-8, n=27; OV-7, n=33). In total, more (P=0.01) OV-8 cows and more (P=0.04) primiparous OV-8 cows had complete luteolysis compared with their OV-7 herd mates. In addition, more (P=0.008) OV-8 cows with BCS<2.75 had complete luteolysis compared with their OV-7 herd mates, whereas no difference was observed between treatments among cows with BCS ≥2.75. In conclusion, delaying the application of PGF2α by 1 day reduced the percentage of primiparous cows and cows with poorer BCS having incomplete luteal regression at the time of AI.
Sero-Prevalence of Bovine Leukemia Virus Infection in Kosovo Cattle
Authors: Gjinovci Valdet , Cana Armend , Alishani Mentor , Mehmetukaj Dafina , Taylor Nick , Honhold Naomi
Published: October 2020

A cross-sectional survey was conducted in Kosovo to determine the presence and prevalence of bovine leukemia virus antibodies in cattle. A total of 5,051 serum samples from 315 villages were collected during 2016. Samples were tested using commercial indirect enzyme-linked immunosorbent assay. At least one sero-positive animal was found in 55 (17.5%) of the villages sampled, of which 23 had more than one sero-positive detected. Overall individual sero-prevalence, corrected for geographic distribution of samples, was found to be 2.26% (95% c.i. 1.62% to 3.04%). There were no statistically significant associations between serological status and herd size or age of animal, although sero-prevalence in 5-year-old cattle was higher than in the other ages. There was a statistical significant heterogeneity in sero-prevalence between different geographic zones of Kosovo (chi-square value = 20.68 (4 d.f.); (p=0.0004). Pairwise comparisons showed that sero-prevalence in the south was significantly higher than in the east and in the north and sero-prevalence in the west was significantly higher than in the north. The 3.11% aggregated sero-prevalence for the two highest sero-prevalence zones, south and west, was significantly higher than the 1.57% aggregated sero-prevalence for the remaining zones, centre, east and north (Fisher exact p-value (2-tail) = 0.0004). The reason for higher prevalence in the south and west of Kosovo is uncertain. These results may serve to enrich the information of bovine leukemia virus distribution in the region, as well as a starting point for the future control and eradication strategy in Kosovo.
Transformation of the identity of a region: Theory and the empirical case of the perceptual regions of Bohemia and Moravia, Czech Republic
Authors: Marek Petr
Published: October 2020

By using the concept of perceptual region – an essential part of the identity of a region and a part of every person’s mental map – this paper demonstrates a way to examine the understudied transformation of (the identity of) a region and, specifically, its territorial shape (boundaries). This concept effectively fuses the “institutionalisation of regions” theory and the methodologies of behavioural geography. This case study of the perceptual regions of Bohemia and Moravia shows how and why these historical regions and their boundary/boundaries developed, after a significant deinstitutionalisation by splitting into smaller regions in an administrative reform. Many people now perceive the Bohemian-Moravian boundary according to the newly-emerged regional boundaries, which often ignore old (historical) boundaries. Thus, the territorial shape of Bohemia and Moravia is transformed, with the Vysočina Region emerging as one of the new regions to witness the most eroded consciousness concerning these historical regions and their boundaries. The impact of administrative reforms on the perception and thus also the transformation of regions and boundaries is obvious, but the results also suggest that the more radical the administrative changes (in terms of toponyms and boundary mismatches), the fuzzier the collective perceptions of historical boundaries become, as well as peoples’ consciousness of historical regions.
“Surely it will come again…”. Flood threat appraisal, mitigation strategies and protection motivation in Czech communities endangered by floods
Authors: Andráško Ivan , Dolák Klemešová Kamila , Dolák Lukáš , Trojan Jakub , Fiedor David
Published: October 2020

A recent “shift” in flood risk management is associated with putting more emphasis on private mitigation and protection measures, and on shared responsibility. Based on case study research in the South Bohemian municipalities (Czech Republic) endangered by floods, this paper reports floods-related attitudes and actions of local inhabitants. A total of 305 respondents participated in a survey; responses and additional commentaries were examined through qualitative content analysis. Results show that though most of the local residents are aware of the constant threat, a minority of them take up any mitigation measures or have some strategy to handle a flood. Several cognitive biases and non-protective responses, the lack of interest and personal responsibility, perceived costs, as well as the prevailing low perceived importance of floods for the local quality of life, hamper improvements in general preparedness. From the viewpoint of Protection Motivation Theory, neither the locals’ threat appraisal nor their coping appraisal is high enough to sufficiently incentivise them to adopt private mitigation strategies and measures. Flood information seems to be at hand for local residents, who are, however, mostly not interested in using it. Perceived obscurities in handling the financial resources contribute to the prevailing unwillingness to participate financially in flood protection. Differences in perceptions and actions are associated with respondents’ individual characteristics (age, gender, level of education, previous experience with floods). Based on our findings, we discuss several relevant policy implications.
ICT as a factor of destination competitiveness: The case of the republics of former Yugoslavia
Authors: Milićević Snežana , Petrović Jelena , Đorđević Nataša
Published: October 2020

The purpose of this paper is to analyze the impact of the Information and communication technology (ICT) on the competitiveness of the republics of former Yugoslavia (Serbia, North Macedonia, Montenegro, Bosnia and Herzegovina, Croatia and Slovenia) as tourism destinations. This paper relies on the correlation analysis and panel regression method. Regression analysis has examined the impact of the ICT on the competitiveness of the republics of Former Yugoslavia (Serbia, North Macedonia, Montenegro, Bosnia and Herzegovina, Croatia and Slovenia) as tourism destinations. The destination competitiveness is measured by international tourist arrivals and international tourism receipts, while the ICT is measured by the ICT Development Index (IDI). The results indicate that the IDI use has a significant impact on the number of international tourist arrivals and an indirect positive impact on the international tourism receipts. The originality of the research lies in the fact there are no previous studies about the impact of ICT on the competitiveness of the republics of former Yugoslavia as tourism destinations. This study contributes to a better understanding of the impact of ICT on the competitiveness of a tourism destination by linking the IDI with tourist arrivals and tourism revenues.
Will they repay their debt? Identification of borrowers likely to be charged off
Authors: Caplescu Raluca Dana , Panaite Ana-Maria , Pele Daniel Traian , Strat Vasile Alecsandru
Published: October 2020

Recent increase in peer-to-peer lending prompted for development of models to separate good and bad clients to mitigate risks both for lenders and for the platforms. The rapidly increasing body of literature provides several comparisons between various models. Among the most frequently employed ones are logistic regression, Support Vector Machines, neural networks and decision tree-based models. Among them, logistic regression has proved to be a strong candidate both because its good performance and due to its high explainability. The present paper aims to compare four pairs of models (for imbalanced and under-sampled data) meant to predict charged off clients by optimizing F1 score. We found that, if the data is balanced, Logistic Regression, both simple and with Stochastic Gradient Descent, outperforms LightGBM and K-Nearest Neighbors in optimizing F1 score. We chose this metric as it provides balance between the interests of the lenders and those of the platform. Loan term, debt-to-income ratio and number of accounts were found to be important positively related predictors of risk of charge off. At the other end of the spectrum, by far the strongest impact on charge off probability is that of the FICO score. The final number of features retained by the two models differs very much, because, although both models use Lasso for feature selection, Stochastic Gradient Descent Logistic Regression uses a stronger regularization. The analysis was performed using Python (numpy, pandas, sklearn and imblearn).
Central Europe between the West and East: Independent Region, the Bridge, Buffer Zone or ‘eternal’ Semi-Periphery?
Authors: Cabada Ladislav
Published: October 2020

The development of new East-Central European (ECE) democracies after 1989 might be separated into two different parts regarding the external, but in many ways also the internal evaluation. While the first fifteen years, crowned the ‘big bang’ EU-enlargement in 2004, might be evaluated generally as a successful story of socialisation into the Western structures, i.e. democratisation and Europeanisation, the next fifteen years are often evaluated as the period of getting sober. Paradoxically, instead of a continuation of the Europeanisation of values, memory and identity in many ECE nations we can observe the strengthening of anti-EU and anti-European attitudes. As Ágh stressed in his latest works, as early as the 2008 financial crisis outbreak we have had to deal with the polycrisis situation accompanied with de-Europeanisation, failure in the catching up process, the strengthening of the Core-Periphery divide in the EU/ Europe and the decline of democracy in East-Central Europe. Even the migration crisis in 2015 and beyond strengthened the mental gaps between so-called ‘old’ and ‘new’ Europe. In the article I focus on reasons for the semi-peripheral position of ECE, long durée processes in the creation of European macro-regions, and specific features of ECE nations’ identity. I reject the black-and-white division of Europe into two regions, stressing the positive examples from ECE as well as many problems of democratic governance the EU – including the ‘West’ – faces.
Clinical Characteristics and Treatment Results of Childhood Acute Lymphoblastic Leukemia in North Macedonia
Authors: Jovanovska Aleksandra , Trakova-Antevska Zorica , Kocheva Svetlana , Stankovikj Svetlana , Panovska-Stavridis Irina , Dimovski Aleksandar , Martinova Kata
Published: October 2020

Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. This study was designed to determine the clinical, biological features and outcomes among children with ALL treated at the only pediatric hematology-oncology center in North Macedonia.

Patients and methods: Seventy four consecutive children age 1 to 14 years, diagnosed with ALL between January 1, 2010 and October 31, 2017 and treated according to ALL IC BFM 2002 protocol were retrospectively evaluated.

Results: The median age at diagnosis was 5 years and males were predominant (60.8%). Precursor B-cell ALL was diagnosed in 81.1% of patients, while 18.9% had T cell ALL. CNS involvement at the time of diagnoses was present in 6.8% of patients. Complete remission was achieved in 93.2% of patients. The induction death rate was 5.4%. The rate of death during first complete remission was 4.1%. Relapse occurred in 13.5% of patients. After a median observation time of 44 months, the 5-year overall survival (OS) and event-free survival (EFS) rates (± standard error) were 79.4% ± 5.2% and 74% ± 5.7%, respectively. The 5-year EFS rate for patients categorized as standard risk by NCI criteria was significantly higher than for high risk patients (83.3% versus 46.7%; P<0.001). Patients with precursor B-cell ALL and negative minimal residual disease (MRD) status at the end of induction had the best prognoses.

Conclusion: Our study demonstrated that the treatment results of childhood ALL in North Macedonia are comparable to those obtained in the ALL IC BFM 2002 trial.
Different Approaches to Developing Writing Skills
Authors: Dragomir Isabela Anda , Niculescu Brânduşa-Oana
Published: October 2020

Writing has traditionally been a neglected area of foreign language teaching, and most probably the least popular skill to acquire among students. However, it has lately emerged as an important element of the communication dyad, which also involves speaking, i.e. the oral manifestation of social interaction and exchange of information. When explaining writing in practical terms, the focus falls on showing that there should be a link between real-life needs and instruction, both from the perspective of the language and from that of the task. Understanding writing systematically not only guarantees successful writing outcomes, but also leads to the acquisition of a secondary set of language-related abilities: an informed selection of grammar and lexical structures; a logical pattern of organization in the development of ideas; an appropriate choice of register and style; an overall better approach to writing tasks and contextualizations. This article aims to discuss writing as a productive skill while proposing six different approaches that successfully marry both the linguistic dimension and the task-related awareness students need to acquire in order to successfully express themselves in written forms.
Completely resected stage III melanoma controversy - 15 years of national tertiary centre experience
Authors: Peric Barbara , Milicevic Sara , Perhavec Andraz , Hocevar Marko , Zgajnar Janez
Published: October 2020

Background

Two prospective randomized studies analysing cutaneous melanoma (CM) patients with sentinel lymph node (SLN) metastases and rapid development of systemic adjuvant therapy have changed our approach to stage III CM treatment. The aim of this study was to compare results of retrospective survival analysis of stage III CM patients’ treatment from Slovenian national CM register to leading international clinical guidelines.

Patients and methods

Since 2000, all Slovenian CM patients with primary tumour ≥ TIb are treated at the Institute of Oncology Ljubljana and data are prospectively collected into a national CM registry. A retrospective analysis of 2426 sentinel lymph node (SLN) biopsies and 789 lymphadenectomies performed until 2015 was conducted using Kaplan-Meier survival curves and log-rank tests.

Results

Positive SLN was found in 519/2426 (21.4%) of patients and completion dissection (CLND) was performed in 455 patients. The 5-year overall survival (OS) of CLND group was 58% vs. 47% of metachronous metastases group (MLNM) (p = 0.003). The 5-year OS of patients with lymph node (LN) metastases and unknown primary site (UPM) was 45% vs. 21% of patients with synchronous LN metastasis. Patients with SLN tumour burden < 0.3 mm had 5-year OS similar to SLN negative patients (86% vs. 85%; p = 0.926). The 5-year OS of patients with burden > 1.0 mm was similar to the MLNM group (49% vs. 47%; p = 0.280).

Conclusions

Stage III melanoma patients is a heterogeneous group with significant OS differences. CLND after positive SLNB might still remain a method of treatment for selected patients with stage III.
Identifying major policy challenges and policy interventions via expert methods
Authors: Dokupilová Dušana , Baláž Vladimír , Kurincová Vladimíra Čavojová , Mikušková Eva Ballová , Gombitová Dagmar
Published: October 2020

This paper presents the application of expert decision methods for the formulation and prioritization of the long-term economic, social and environmental policies in the Slovak Republic. The Partnership Agreement for the Slovak Republic (PA) is an underlying strategy for investments from the European Structural and Investment Funds (ESIF) in the period 2021-2027. Policies implemented under the PA will allocate €13.4b on four policy objectives. This paper concentrates on the policy objective 4 ‘Social development’. The authors co-operated with the Deputy Prime Minister Office and assembled panels of top Slovak experts on social and economic issues. The Delphi and Analytical hierarchy process (AHP) methods were combined for analyzing major development challenges and eliciting policy priorities. The methods combined the bottom-up and top-down approaches to policy making. Nine potential policy measures in three policy areas emerged from the Delphi exercise. The AHP exercise applied three criteria (relevance, urgency and feasibility) to rank the abovementioned measures within three policy areas. As for the Policy Area 1 (Labour market, employment, training and institutions) the measure 4.1.1 ‘Improving access to employment and modernizing institutions and services on labour market’ clearly dominated over the measure 4.1.2 ‘Supporting a better work-life balance’. The measure 4.2.2 ‘Equal access to quality and inclusive education’ emerged substantially more important than measures 4.2.1 ‘Improving the quality and effectiveness of education and training systems’ and 4.2.3 ‘Support to life-long learning’ in the Policy Area 2 ‘Education and skills’. Finally, measures 4.3.2 ‘Supporting social and economic integration of marginalized Roma communities’ and 4.3.3 ‘Ensuring equal access to healthcare including primary care’ received the highest ranks in the Policy Area 3 ‘Health and social services’.
Sorption Properties of Thermal Insulation Composed of Flax or Hemp Fibers
Authors: Hellová Katarína E. , Unčík Stanislav , Cabanová Terézia
Published: October 2020

This paper deals with the sorption characteristics of thermal insulation materials based on flax and hemp. The added value of these materials is a positive impact on healthy and sustainable housing. Flax and hemp, which are classified as organic, have a high sorption capacity. Changes in the properties of these materials at a relative air humidity of 20% – 95% allow us to determine their advantages and disadvantages as well as whether the insulation is suitable for incorporation into a building structure. The article describes an experiment during which hygroscopic and thermal-technical properties were monitored. The most important indicators were the change in the coefficient of thermal conductivity and the change in the equilibrium moisture content.
Effects of Sulfur Amino Acids on Cardiodynamic Parameters of Isolated Rat Heart
Authors: Sobot Nikola , Sobot Tanja , Radonjic Katarina , Turnic Tamara Nikolic , Petkovic Anica , Jeremic Jovana , Ponorac Nenad , Lazarevic Tatjana , Bolevich Sergey , Jakovljevic Vladimir , Djuric Dragan
Published: October 2020

Sulfur-containing amino acids are integral part of molecular mechanisms which underlie many aspects of cellular function and homeostasis, facilitated by reversible changes in oxidation states of sulfur atoms. Dysregulation of these pathways is associated with diverse pathologies, notably of the cardiovascular system, which are typically characterized by inappropriate plasma levels of sulfur-containing amino acids. The aim of this study was to assess the acute, direct effects of sulfur-containing amino acids and inorganic NaHS, as H2S donor, on cardiodynamic parameters in homocysteine treated rats. Moderate hyperhomocysteinemia did not cause significant decrease in myocardial contractility, but our findings suggest that NaHS and L-methionine cause negative effects on cardiac function in hearts of the rats treated with homocysteine, even in a single administration. Further investigations need to be carried out with purpose of better understanding and highlightening the impact of Hcy and sulphur amino acids on cardiac function.
On Intensive Endophoric Devices in English
Authors: Krivochen Diego
Published: October 2020

This paper deals with the syntactic and semantic properties of a specific kind of anaphoric device (AD) in English, instantiated by Prn+SELF lexical items (himself/herself/itself…; ‘SELF’ henceforth), which do not behave like anaphors in the sense of Binding Theory either syntactically or semantically. These devices have received the name ofintensivesin the grammatical literature (Leskosky 1972; Siemund 2000, among many others). We will look at the syntactic behaviour of so-calledintensivesin different syntactic contexts, and refine the classification of these ADs taking into consideration (a) how each type of intensive is derived, (b) the kinds of syntactic rules that can affect them, and (c) their meaning.
Neuroimaging patterns of chronic cerebrovascular insufficiency with evaluation of cerebral perfusion depending on the level of cognitive disorders
Authors: Chukhontseva E. S. , Morozova T. G. , Borsukov A. V.
Published: October 2020

Aim. To evaluate the neuroimaging patterns of chronic cerebrovascular insufficiency with cerebral perfusion assessment depending on the level of cognitive impairment.

Materials and methods. The 58 patients aged 50–79 years were examined: 45 patients with a diagnosis of сhronic cerebrovascular insufficiency and 13 conditionally healthy volunteers. Patients with Chronic cerebrovascular insufficiency were ranked into three subgroups depending on the severity of cognitive impartment (CI). T1-, T2, T2*- VI, DWI, FLAIR and non-contrast MR perfusion (ASL) were included in the MR-protocol (Toshiba Vantage Titan, 1.5 T). The analysis of MRM patterns of Chronic cerebrovascular insufficiency was carried out according to STRIVE criteria. The total cerebral blood flow and regional in the frontal and parietal lobes were evaluated by the ASLperfusion.

Results. A relationship was found between the degree of leukoaraiosis, the type of expansion of the perivascular spaces of Virchow-Robin and the level of CI. According to ASL, total cerebral blood flow is higher in groups without CI and in patients with severe CI. There is a diffuse decrease of cerebral perfusion in patients with mild CI. This phenomenon is explained by initial impairment of the blood-brain barrier permeability, damage to the microvasculature. Relative hyperperfusion in the cortex of the frontal and parietal lobes of patients with dementia indicates the ineffectiveness of increased cortical blood flow and the resulting shunt blood flow due to the high resistance of the altered small cerebral vessels under high pulsating properties of the main arteries.

Conclusion. ASL perfusion is a complementary link to the STRIVE criteria in the diagnosis of chronic cerebrovascular insufficiency. The absence of changes in cerebral perfusion in patients with subjective manifestations of chronic cerebrovascular insufficiency makes it advisable to search for new methods for the diagnosis of preclinical stages of vascular cognitive impairment.
2D Speckle Tracking echocardiography in the prognostication of left ventricle diastolic dysfunction
Authors: Zherko O. M. , Shkrebneva E. I.
Published: October 2020

The aim of the study: to develop prediction comprehensive criteria for the diastolic dysfunction (DD) of the left ventricle (LV) according to 2D Speckle Tracking echocardiography (STE).

Materials and methods. A clinical and instrumental study of 91 patients aged 64.0 was performed [58.0; 70.0] years in the Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology in 2019. Criteria for inclusion: sinus rhythm, essential arterial hypertension, chronic coronary artery disease, previous left myocardial infarction, after which at least six months have passed to stabilize the LV structural and functional parameters, chronic heart failure, patient informed consent. Exclusion criteria: primary mitral regurgitation, mitral stenosis, mitral valve repair or prosthetics, congenital heart defects, acute and chronic diseases of the kidneys, lungs. Transthoracic echocardiography and STE was performed on ultrasound machine Vivid E9 (GE Healthcare, USA).

Results. The leading functional anomalies, interconnected in the development of LV DD, are decline of the LV longitudinal diastolic, regional and global systolic strain, LV mechanical dispersion and dyssynergy. Correlations between LV DD type II and the mechanical dispersion index (r = 0.69, p < 0.001), delta of LV time to peak longitudinal deformation (r = 0.66, p < 0.001), LV global post-systolic index (r = 0.58, p < 0.001), GLSAVG (r = 0.63, p < 0.001) were established. LV DD is characterized by early diastolic longitudinal strain E of the LV basal lateral segment > −6.75%, LV basal septal segment > −5.22%, early and late diastolic longitudinal strain ratio E/A of the LV basal lateral segment ≤0.91, basal-septal segment ≤0.69. LV DD type I is characterized by an LV mechanical dispersion index >49.34 ms, LV delta time to peak longitudinal strain >157 ms. Prognostic values for LV DD type II are LV mechanical dispersion index >49.34 ms, delta time to peak longitudinal strain is >136 ms, global post-systolic index >6.24%, mechanical dyssynergy index >4.60%, global LV peak longitudinal displacement ≤9.88 mm, GLSAVG > −18.5% (sensitivity 88.2%, specificity 83.3%).

Conclusions. The use of the developed STE prediction value in practical public health will increase the efficiency of diagnosis of LV DD.
EVALUATION OF DIAGNOSTIC QUALITY CRITERIA OF EMERGENCY CARE FOR DISEASES OF SURGICAL PROFILE AT EMERGENCY DEPARTMENTS
Authors: Alimov R. R. , Miroshnichenko A. G. , Lataria E. L. , Turov I. A.
Published: October 2020

The article presents an analysis of diagnostic criteria of quality evaluation for emergency medicine and specialized medical care in emergency departments. The results of the study of emergency medicine care in compliance with quality evaluation criteria showed that in groupe of general criteria for quality evaluation it was achieved in 100 prc cases, in groupe of evaluation criteria of extent of medical aid - in 97,4 prc cases, n groupe of evaluation criteria of timely diagnosis and treatment — 98,2 prc. It also shows the high level of medical care in this department.
ENHANCEMENT AND DEVELOPMENT OF THE AMBULANCE SERVICES IN PAVLODAR REGION
Authors: Akhmentzhanov K. K. , Krylova S. G.
Published: October 2020

This article contains a historical overview on development of ambulance in Pavlodar, suggests the ways and methods for improvement of the organization of the ambulance, demonstrates the results of implantation of the ambulance reformation projects, and defines goals and algorithms for the advanced effectiveness of ambulance performance
EFFICIENCY OF HEMOSTASIS ENDOSCOPIC METHODS FOR HEMORRHAGE FROM VARIOUSLY EXTENDED VESES OF THE ESOPHAGOD
Authors: Kadirov R. N. , Hadjibaev F. A. , Akhmedov Y. M. , Minnulin E. R.
Published: October 2020

Relapses of gastroesophageal hemorrhage in patients with portal hypertension are one of the most difficult problems of modern medicine.
Alms-Awareness Behavior, Serotonin Hormone, and Corporate Age
Authors: Hasbiyadi La Ode Sumail,
Published: October 2020

Humans who are fragmented in their souls or (split personality) are easily infested with mental poisons, so we need detolks in the form of alms. We investigate the influence of religiosity, attitudes and subjective norms on alms awareness and impact on corporate age through the role of the hormone serotonin. Because the characteristics of PT Haji La Tunrung's ownership are family ownership and are currently directed by second generation family members, it is interesting to be chosen as the object of research. We believe that owners, managers and employees can provide accurate and quality information (purposive sampling) and analyze data using WarpPLS 7.0. We find that the better religiosity, attitudes and subjective norms the higher the awareness of charity and the age of corporations increases. Sadaqah awareness can increase the hormone serotonin. Therefore, the hormone serotonin can increase self-confidence for individuals and corporations and performance is good so that the age of corporations increases. We also find that higher levels of formal education are not the only determinant of alms awareness.
The Influence of Brand Awareness, Brand Image, and Brand Trust on Brand Loyalty
Authors: Yohana F. C. P. Meilani, Innocentius Bernarto, Margaretha P. Berlianto, , Ian N. Suryawan Ronnie R. Masman,
Published: October 2020

The aim of this research is to examine the positive influence of brand awareness, brand image, and brand trust on brand loyalty. The coffee shop business in big cities in Indonesia is growing rapidly. Each coffee shop strives to show its uniqueness. This competition has resulted in them competing to increase competitiveness by using logos, symbols, unique names – or what is usually called a brand to become a differentiator among the competitors. This study was done in a quantitative manner. The data was collected by using a questionnaire distributed using a survey method. Using a snowball sampling, a total of 436 samples were used and analyzed statistically using the partial least square – structural equation modeling (PLS-SEM) approach using SmartPls 3.0 program. The results show that brand awareness and brand trust had a positive effect on brand loyalty. However, the brand image did not have a positive effect on brand loyalty. This study is expected to provide input to the coffee shop management on how to increase their brand loyalty which can be done by increasing their brand awareness, brand image, and brand trust.
How Perceived Usefulness and Perceived Ease of Use Affecting Intent to Repurchase?
Authors: Keni Keni
Published: October 2020

This study was commenced in order to determine whether or not perceived usefulness and perceived ease of use positively affecting consumers’ intention to repurchase, both in a direct and indirect manner through both trust and customer satisfaction. A sum of 250 respondents joined this study, while a total of 236 data were deemed usable to be further processed and analyzed in this study. Survey method was applied in this study, in which all of the data gathered from the respondents using questionnaires which were distributed both personally and electronically. All of the data then were analyzed using PLS-SEM method. In accordance with the results, author conclude that both perceived usefulness and perceived ease of use play a significant and important role in affecting consumers’ intention to repurchase, both directly and indirectly toward customer satisfaction and trust, in which trust plays a stronger role as a mediator as compared to satisfaction.
Análisis para detección de mermas en órdenes de producción de una imprenta
Authors: Rodríguez Juárez Jorge David , Romero Flores Edna Araceli , Cabrera Zepeda Gabriela
Published: October 2020

Este artículo describe el proyecto de investigación realizado a una imprenta en la ciudad de Orizaba, Ver. para identificar y determinar el costo por mermas mediante la aplicación de herramientas administrativas como son: muestreo, diagrama de flujo y SMED. La metodología utilizada consiste en un análisis de información histórica de las órdenes de producción de los meses de julio a octubre de 2018, llevando a cabo la observación directa de los cuatro procesos de impresión, la toma de tiempos de las actividades ejecutadas por el operador para la preparación máquinas e impresión y el seguimiento de la orden de producción por los departamentos desde su creación hasta la conclusión.
Propuesta metodológica del indicador “Grado de Felicidad Local”, asociación de indicadores relativos a la felicidad, bienestar y estado de ánimo
Authors: García Leyva Alberto
Published: October 2020

Se aborda el tema de la felicidad y bienestar para proponer el indicador Rango de Felicidad Local, que agrupa variables del INEGI y el Banco de México, así como el World Happiness Report de la Red de Soluciones de Desarrollo Sostenible de las Naciones Unidas y otras fundaciones. La prueba piloto calculada para el estado de Veracruz, México, arroja un resultado de 46.23%, el indicador tiene cualidades adaptativas, se puede calcular diariamente, y provee información a los tomadores de decisiones.
Síndrome de Burnout en época de pandemia: caso colombiano
Authors: De Arco Paternina Lilian Karina , Castillo Hernández José Andrés
Published: October 2020

En este artículo se hace una revisión de la literatura entre los años 2018 y 2020 sobre el Síndrome de Burnout (SB). Se trata de determinar qué impacto tiene éste en los profesionales colombianos (especialmente durante la pandemia actual), qué tendencias hay sobre el tema, y la contribución teórica que abordan. Primero, se contextualiza el marco de estudio con base al síndrome de burnout y su incidencia en diversas profesiones, luego, se expone la metodología que encauzó la revisión bibliográfica. El síndrome de Burnout ha sido (y aún sigue siendo) objeto de estudio en numerosas investigaciones desde hace más de tres décadas. Es así como, a través de estas, se ha observado su incidencia de forma distinta dependiendo del área de desempeño de cada profesión. De aquí la importancia de conocer en qué consiste el síndrome de burnout, síntomas y cómo las situaciones que enfrentan actualmente los profesionales del país a raíz de la pandemia hacen que se vuelva la mirada al mismo.
Evaluación de aspectos agronómicos en dos sistemas de siembra de caña de azúcar (Saccharum Officinarum L)
Authors: Villegas Gómez Esteban , Eliseo Hernández Jorge Freddy
Published: October 2020

Tradicionalmente se ha utilizado la siembra de semilla de caña corta en las áreas de producción azucarera del Valle del Cauca. El objetivo de esta estudio fue evaluar otro sistema de siembra (caña larga) y compararlo con el sistema tradicional (caña corta), tomando como punto de referencia aspectos productivos (número de yemas) y económicos. Se realizaron dos tratamiento uno con semilla de caña larga y otro de caña corta con cuatro hectáreas cada uno. Se analizaron las variables vigor de germinación, emergencia y establecimiento. Solo se presentaron diferencias estadísticas en vigor de la germinación para la semilla de caña larga, el cual presentó un promedio mayor de yemas germinadas por tallo (8,5) y un número total de yemas superior al de la caña corta (7,6). Este estudio concluyó que el uso de semilla de caña larga puede mejorar el rendimiento de semilla por hectárea ya que se disminuye el material necesario para esta actividad, además se demostró que el uso de semilla de caña larga es más económico que el sistema tradicional de siembra (caña corta).
El papel del estado en el origen de las actividades económicas en una región periférica de Colombia: Análisis comparativo entre la minería y la agroindustria
Authors: Andrade Navia Juan Manuel
Published: October 2020

La evolución de actividades económicas, impulsadas por agentes empresariales, se constituye en objeto de estudio para comprender en toda su expresión, la realidad actual de las regiones. A la par, el apoyo que estructural o coyunturalmente puedan generar las instituciones del Estado se convierte en un elemento más en el estudio del surgimiento y desarrollo de las actividades que dinamizan la economía. Es en esta lógica que el presente estudio procura identificar y comprender el papel del Estado en el origen de las actividades económicas, para el caso particular de la minería y la agroindustria, en el departamento del Huila (región periférica de Colombia). Se pretendió comprender el fenómeno mediante la identificación y caracterización de las actividades económicas y sus relaciones con el Estado.En efecto se determinó que el Estado juega un papel determinante en el surgimiento y consolidación de actividades económicas o en su defecto en las condiciones en las que históricamente se encuentran. En efecto, se aprecia un estímulo a las actividades mediante la financiación de estudios técnicos que permitiesen determinar las potencialidades del sector en el que se encuentran inmersas. Sin embargo, su rol en ocasiones se limita a labores de control y/o supervisión con pocos esfuerzos para su desarrollo.
Histopathological analysis of the gills of fresh water fish Channa gachua exposed to fungicide Pydiflumetofen
Authors: Pallavi Shweta
Published: October 2020

Indiscriminate use of pesticides has become a serious problem among human and ambient environment. The present study is aimed to assess the damage caused to the fish Channa gachua (family: Channidae) exposed to fungicide Pydiflumetofen. Respiration in Channa gachua mainly occurs through their gills. Any change in the chemical quality of water directly affects the structure and function of gills. Fish gill also helps in osmoregulation and excretion besides respiration. When fish exposed to sub-lethal concentration of Pydiflumetofen pesticide for 10 days, 15days and 20days include Curling and fusion in secondary lamellae, Hyperplasia, reduction in the respiratory surface area of filaments, fusion at the tip of the lamellae, sub lamellar and sub epithelial space occur.
PENGARUH KOMPETENSI ETOS KERJA PETUGAS TERHADAP KEPUASAN PASIEN DI KLINIK FISIOTERAPI RSUD DATU BERU TAKENGON KABUPATEN ACEH TENGAH TAHUN 2019
Authors: Sirait Asmarani Yusnita Ida , Fitriani Arifah Devi , Lubis Masnelly
Published: October 2020

Abstrak

 

Kesehatan telah menjadi kebutuhan pokok bagi masyarakat. Penelitian ini bertujuan menganalisis pengaruh kompetensi etos kerja petugas terhadap kepuasan pasien. Jenis penelitian yang digunakan adalah Survey Analitik dengan pendekatan Cross Sectional Study. Instrumen yang digunakan adalah lembar kuesioner yang dibagikan kepada 60 responden secara analisis dengan uji regresi logistik berganda. Hasil analisis data menunjukkan ada pengaruh terhadap kepuasan pasien yaitu variabel kedisiplinan petugas, ketelitian petugas dan tanggung jawab petugas dengan nilai p (sig) = < 0,05. Variabel yang paling dominan memiliki pengaruh terhadap kepuasan pasien adalah ketelitian petugas dengan p (sig) 0,002 dan memiliki nilai OR= 13.360. Kesimpulan penelitian terdapat hubungan kompetensi etos kerja petugas ditinjau dari kedisiplinan, kejujuran, ketelitian, tanggung jawab, dan kematangan emosi petugas fisioterapi terhadap kepuasan pasien. Saran meningkatkan kedisiplinan, kejujuran, ketelitian, tanggung jawab, dan kematangan emosi supaya pasien puas dalam menerima pelayanan fisioterapi yang diberikan.
Hubungan Persepsi Body Image dengan Status Gizi Remaja Pada Siswa SMPN 8 di Pekanbaru
Authors: Marlina Yessi , Ernalia Yanti
Published: October 2020

Dampak dari ketidakpuasan terhadap bentuk tubuh menjadi faktor pendorong untuk melakukan diet penurunan berat badan. Apabila tidak diimbangi dengan pengetahuan yang cukup, para remaja dapat terjebak dalam diit yang salah, menyebabkan penurunan status gizi, kekurangan zat besi, dan lain-lain. Penelitian ini bertujuan untuk mengetahui hubungan persepsi body image terhadap status gizi siswa SMPN 8 Pekanbaru. Jenis penelitian ini adalah deksriptif dengan desain cross sectional. Sampel penelitian adalah siswa SMPN 8 Pekanbaru berjumlah 160 siswa yang dipilih secara random. Persepsi body image diukur menggunakan kuisioner BSQ34 sedangkan status gizi menggunakan timbangan dan microtoise. Analisa data berupa uji regresi sederhana. Hasil penelitian menunjukkan korelasi positif antara persepsi body image dengan status gizi (IMT/U) (p=0,000; r=0,526), setiap kenaikan 1 poin skor persepsi body image, diprediksikan status gizi (IMT/U) meningkat sebesar 0,03kg/m2. Jumlah responden yang menyatakan puas terhadap bentuk tubuhnya sebesar 62,5% dan yang tidak puas 37,5%. Status gizi responden adalah 3,1% sangat kurus, 6,3% kurus, 63,8% normal, 18,1% gemuk dan 8,8% obesitas. Perlunya pendekatan psikologi dari sekolah dalam meningkatkan kepercayaan diri siswa terhadap bentuk tubuh masing-masing.
Pelaksanaan Penilaian Autentik Pada Pembelajaran PPKn Pada Sekolah Menengah Atas Di Kota Semarang
Authors: Wahono Margi
Published: October 2020

Penilaian yang dilaksanakan oleh guru digunakan untuk memantau proses, kemajuan belajar dan perbaikan hasil belajar peserta didik secara berkelanjutan yang digunakan untuk menilai pencapaian kompetensi peserta didik. Penelitian ini bertujuan untuk mendeskripsikan pemahaman guru tentang penerapan penilaian kurikulum 2013, mendeskripsikan permasalahan guru dalam penerapan penilaian kurikulum 2013, kendala-kendala guru serta upaya yang dilakukan guru dalam mengatasi permasalahan penerapan penilaian kurikulum 2013 pada Sekolah Menengah Atas di Kota semarang. Jenis peneltian ini adalah penelitian kualitatif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Teknik pemeriksaan keabsahan data dilakukan dengan triangulasi teknik dan sumber. Penelitian menunjukkan pada jenjang Sekolah Menengah Atas Di Semarang dalam pembelajaran PPKn telah melaksanakan penilaian autentik. Penilaian autentik ini diharapkan mampu meningkatkan kemampuan afektif siswa sehingga siswa tidak hanya unggul dalam bidang kognitif saja. Namun, dalam pelaksanaanya penilaian autentik mengalami beberapa hambatan seperti karakter siswa dalam setiap kelas berbeda-beda, alokasi waktu yang terbatas, dan temuan dilapangan adalah guru merasa kurang memahami pelaksanaan penilaian autentik karena minimnya sosialisasi dan pelatihan mengenai penilaian autentik. Penulis memberikan rekomendasi khususnya pada guru agar lebih mengoptimalkan penerapan penilaian autentik dalam penilaian pembelajaran PPKn.
Chelating Agent: The Health Protector of Researchers in Lead Halide Perovskite Laboratory
Authors: Deng Yu-Hao
Published: October 2020

Lead halide perovskites have achieved substantial success in various optoelectronic devices owing to their remarkable physical properties. However, lead (Pb) as a heavy metal, long-lasting toxic to the body has become a health hazard for researchers. How to completely remove the residual lead in the laboratory and prevent lead from entering the human body have always been an important topic in laboratory safety. Here we develop an operable method to treat lead sources with low-cost and eco-friendly chelating agent (EDTA-2Na), which can reduce the concentration of free lead ions to 10-11 ppm theoretically. Moreover, experiments have demonstrated that the chelating agent possess a strong ability on the removal of lead ions from the lab surface, gloves and lab coats. This approach paves the way to protect the health of researchers in lead halide perovskite laboratory.
Identification of Small-Molecule Inhibitors of FGF23 Signaling via In Silico Hot Spot Prediction and Molecular Docking to α-Klotho
Authors: Liu Shih-Hsien , Xiao Zhousheng , Mishra Sambit K. , C. Mitchell Julie , Smith Jeremy C. , Quarles L. Darryl , Petridis Loukas
Published: October 2020

Fibroblast growth factor 23 (FGF23) is a therapeutic target for treating hereditary and acquired hypophosphatemic disorders, such as X-linked hypophosphatemic (XLH) rickets and tumor-induced osteomalacia (TIO), respectively. FGF23-induced hypophosphatemia is mediated by signaling through a ternary complex formed by FGF23, FGF receptor (FGFR), and alpha-Klotho. Currently, disorders of excess FGF23 are treated with an FGF23-blocking antibody, Burosumab. Small-molecule drugs that disrupt protein:protein interactions necessary for the ternary complex formation offer an alternative to disrupt FGF23 signaling. In this study, the FGF23:alpha-Klotho interface was targeted to identify small-molecule protein:protein interaction inhibitors. We computationally identified “hot spots” in the FGF23:alpha-Klotho interface of the ternary complex and performed in silico docking of ~5.5 million compounds from the ZINC database to the interface region of alpha-Klotho from the ternary crystal structure. Following docking, 23 and 18 compounds were chosen based on the lowest binding free energies to alpha-Klotho and the largest number of contacts with Tyr433, a predicted hot spot, respectively. 5 compounds available were assessed experimentally by their FGF23-mediated extracellular signal-regulated kinase (ERK) activities in vitro, and two of these reduce activities significantly. Both these compounds have a favorable predicted binding affinity, but not a large number of contacts with the hot spot residues. ZINC12409120 was found experimentally to reduce FGF23-mediated ERK activities by 70% and have a half maximal inhibitory concentration (IC50) of 5.0 ± 0.23 uM. ZINC12409120 exhibits contacts with residues on KL1 and KL2 domains and on the linker between the two domains of alpha-Klotho in in silico binding poses, thereby possibly disrupting the regular function of alpha-Klotho and impeding FGF23 binding. ZINC12409120 is a candidate for lead optimization.