bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational Study of Lactucine and its Derivatives with Apoptosis Inducing Proteins of Various Pathways
Authors: Arya Mamta , Tiwari Apoorv , Singh Dev Bukhsh , Taj Gohar
Published: August 2021

In the present computational study, we found that lactucin 15-oxalate a chemical component present in the cichorium intybus (chicory) has a potential apoptosis inducing effect in human leukemia cancer cell and may acts as an anticancer agent. Lactucine and its derivatives were used as ligand molecules to trace out its binding interactions with proteins involved in apoptosis and these ligands were docked with different apoptosis inducing protein such as caspases, cytochrome C, apaf-1, CDKs, etc involved in cell cycle regulation. Among lactucine derivatives, the lactucin 15-oxalate showed virtuous affinity for the apoptosis inducing protein. In addition to this, the number of the hydrogen bonding was higher with lactucin 15-oxalate as compare to other derivatives which indicates its suitability as an anticancer agent. An apoptosis inducing agent if implemented for the treatment of leukemia cancer, then it can reduce the use of multidrug dose therapy and chemotherapeutic drugs. However, different in vitro as well as clinical trials are needed for further validation of the lactucin 15-oxalate.
Digital Simulation Assessments of the Sensitivity of Quantitative MRI for Detection of an Iron Oxide Nanoparticle Brain MRI Contrast Agent
Authors: Kim Joong , Wang Wen-Tung , Knutsen Andrew , Brody David
Published: August 2021

There have been substantial efforts to develop targeted exogenous MRI contrast agents to assess specific brain pathologies. In parallel with other efforts, it is important to assess the sensitivity of candidate MRI methods for detection of contrast agents. Here, we propose a digital simulation approach, which includes MR relaxation (R1 and R2) mapping and image co-registration. We simulated the effects of 3 nm iron oxide nanoparticles (IONPs) as a model contrast agent. Two independent relaxation maps acquired from the brain of the same subject were co-registered. The baseline subtraction between the two relaxation maps showed good agreement, demonstrating the high reproducibility of the method. Next, the second relaxation map was digitally altered (“seeded”) to simulate additional MR relaxation values corresponding to several concentrations of 3 nm IONPs in various locations. The maps of absolute differences between the first relaxation map and the digitally altered second relaxation maps were assessed for conspicuity. Results based on living mouse and human brains scanned at 9.4 T and 3.0 T respectively both indicated reliable conspicuity for signal equivalent to 0.06 mM IONP or higher. Overall, the digital simulation approach is a useful method to improve the development of MRI contrast agents and accompanying MRI methodologies.
A Metamaterial-Inspired Microwave Sensor for Dielectric Characterization of Organic Liquids and Solid Dielectric Substrates
Authors: CAO YUNHAO , Ruan Cunjun , Chen Kanglong , Zhang Xingyun
Published: August 2021

A microwave metamaterial-inspired sensor based on a 13×13 arrays of Asymmetric Electric Split-Ring Resonator (AESRR) is proposed for dielectric characterization of organic liquids and solid dielectric substrates with low permittivity. The sensor, excited by a pair of patch antennas and working at around 11.575 GHz, is fabricated using printed circuit board (PCB) technology. T-shape channel was integrated to the sensor by grooving in the FR-4 substrate which improved the integration and provided the feasibility of liquids detection. Seven liquids and four dielectric substrates are measured by this sensor. The measured results show the transmission frequency shifts from 11.575 GHz to 11.150 GHz as the liquid samples permittivity changes from 1 to 7 and the transmission frequency shifts from 11.575 GHz to 8.260 GHz as the solid substrates permittivity changes from 1 to 9. The measured results have proven the improved sensitivity and the larger frequency shift ∆f on material under test (MUTs) compared with the conventional reported sensor. The relative permittivity of liquid samples and solid samples can be fitted by establishing approximate models in CST, respectively. Two transcendental equations derived from measured results are proposed to predict the relative permittivity of liquid samples and solids samples. The accuracy and reliability of measured results and predicted results are numerically verified by comparing them with literature values. The proposed sensor has many advantages, such as low-cost, high-sensitivity, high-robustness, and extensive detecting range, which provided a great potential to be implemented in a lab-on-a-chip sensor system in the future.
Machine Learning Classifier Models Can Identify Delirium in Intensive Care Units
Authors: Hu Anmin , Li Hui-Ping , Li Zhen , Zhang Zhongjun , Zhong Xiong-Xiong
Published: August 2021

Purpose: The aim of this study was to use machine learning to construct a model for the analysis of risk factors and prediction of delirium among ICU patients.Methods: We developed a set of real-world data to enable the comparison of the reliability and accuracy of delirium prediction models from the MIMIC-III database, the MIMIC-IV database and the eICU Collaborative Research Database. Significance tests, correlation analysis, and factor analysis were used to individually screen 80 potential risk factors. The predictive algorithms were run using the following models: Logistic regression, naive Bayesian, K-nearest neighbors, support vector machine, random forest, and eXtreme Gradient Boosting. Conventional E-PRE-DELIRIC and eighteen models, including all-factor (AF) models with all potential variables, characteristic variable (CV) models with principal component factors, and rapid predictive (RP) models without laboratory test results, were used to construct the risk prediction model for delirium. The performance of these machine learning models was measured by the area under the receiver operating characteristic curve (AUC) of tenfold cross-validation. The VIMs and SHAP algorithms, feature interpretation and sample prediction interpretation algorithms of the machine learning black box model were implemented.Results: A total of 78,365 patients were enrolled in this study, 22,159 of whom (28.28%) had positive delirium records. The E-PRE-DELIRIC model (AUC, 0.77), CV models (AUC, 0.77-0.93), CV models (AUC, 0.77-0.88) and RP models (AUC, 0.75-0.87) had discriminatory value. The random forest CV model found that the top five factors accounting for the weight of delirium were length of ICU stay, verbal response score, APACHE-III score, urine volume and hemoglobin. The SHAP values in the eXtreme Gradient Boosting CV model showed that the top three features that were negatively correlated with outcomes were verbal response score, urine volume, and hemoglobin; the top three characteristics that were positively correlated with outcomes were length of ICU stay, APACHE-III score, and alanine transaminase.Conclusion: Even with a small number of variables, machine learning has a good ability to predict delirium in critically ill patients. Characteristic variables provide direction for early intervention to reduce the risk of delirium.
Oral administration of E-type prostanoid (EP) 1 receptor antagonist suppresses carcinogenesis and development of prostate cancer via upregulation of apoptosis in an animal model
Authors: Miyata Yasuyoshi , Masato Masahito , Mitsunari Kensuke , Asai Akihiro , Nakamura Yuichiro , Araki Kyohei , Mukae Yuta , Matsuda Tsuyoshi , Harada Junki , Matsuo Tomohiro , Ohba Kojiro , Sakai Hideki , Kurata Hiroki
Published: August 2021

Prostaglandin E2 plays important roles in carcinogenesis and malignant potential of prostate cancer (PC) by binding to its specific receptors, E-type prostanoid (EP) receptors. However, anti-carcinogenic effects of EP receptor antagonist are not clear. In this study, feed with or without EP1 receptor antagonist were given to a mouse model of prostate cancer. The mice were sacrificed at 10, 15, 30, and 52 weeks of age. Apoptosis was evaluated by immunohistochemical analysis using cleaved caspase-3. The incidence of cancer in the experimental group was significantly lower than that in the control group at 15, 30, and 52 weeks of age. The percentage of poorly differentiated PC cells was significantly lower in the experimental group than in the control group at 30 and 52 weeks of age. The survival period in the experimental group was significantly longer than that in the control group, and the percentage of apoptotic cells in the experimental group was significantly higher than that in the control group at 15, 30, and 52 weeks of age. Thus, an EP1 receptor antagonist delayed PC progression via the upregulation of apoptosis. We suggest that EP1 receptor may be a novel chemopreventive agent for the development of PC.
Sleep Disturbance and Depressive Tendency in Bed Partners of Patients With Obstructive Sleep Apnea
Authors: Chu Chien-Ming , Wu Shao-Yun , Yu Chung-Chieh , Huang Chih-Yu
Published: August 2021

Snoring, apnea, and arousal are commonly observed during sleep in patients with obstructive sleep apnea (OSA), and these nocturnal symptoms frequently disturb their bed partners. We aimed to evaluate the sleep disturbance and depressive tendency in the bed partners of patients with OSA. A cross-sectional, prospective study was conducted. A total of 136 patients with OSA and their bed partners were recruited. We analyzed the demographic data of both patients with OSA and bed partners and the polysomnography parameters of patients with OSA. The sleep quality of bed partners was assessed using the Chinese version of the Pittsburgh Sleep Quality Index (PSQI), and depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale (CES-D). The mean apnea–hypopnea index (AHI) was 43.5/h among all participants (76.5% male). Among bed partners, the mean PSQI score was 7.8 and the mean CES-D score was 15.4. The prevalence of chronic disease was significantly higher in bed partners with sleep disturbance (PSQI > 5) and depressive tendency (CES-D ≥ 16). The AHI and snore index of patients with OSA were not associated with bed partners’ sleep disturbance and depressive tendency, which were stratified according to PSQI (> 5 and ≤ 5) and CES-D (≥ 16 and < 16), respectively. The CES-D score was positively correlated with the PSQI score in the bed partners of patients with OSA (r = 0.426, p < 0.001). Bed partners tended to have sleep disturbance, which was unrelated to the severity of AHI and snoring in patients with OSA. Poor sleep quality may cause depressive tendency and chronic disease in the bed partners of patients with OSA.
Equiprobable Symbolization Pattern Entropy for Time Series Complexity Measurement
Authors: Wang Fuyi , Zhang Leo Yu
Published: August 2021

In order to more effectively mine the structural features in time series, while simplifying the complexity of time series analysis, equiprobable symbolization pattern entropy (EPSPE) based on time series symbolization combined with sliding window technology is proposed in this paper. Firstly, time series are implemented symbolic procession according to the equal probability distribution of the original data, which greatly simplifies the difficulty of analyzing the signal on the premise of small loss of precision to the original signal. Then, sliding window technique is used to obtain a finite number of different symbolic patterns, and the pattern pairs are determined by calculating the conversion between the symbolic patterns. Next, the conversion frequency between symbolized patterns is counted to calculate the probability of the pattern pairs, thus estimating the complexity measurement of complex signals. The results of test using the Logistic system with different parameters show that compared with multiscale sample entropy(MSE), EPSPE can more concisely and intuitively reflect the structural characteristics of time series. Finally, EPSPE is used to investigate the natural wind field signals collected at an outdoor space in which nine high precision two-dimensional (2D) ultrasonic anemometers are deployed in line with 1m interval. The values of EPSPE show consistent increase or decrease trend with the spatial regular arrangement of the nine anemometers. While the results of MSE are irregular, and cannot accurately predict the spatial deployment relationship of nine 2D ultrasonic anemometers.
Association and Transcription Analyses Identify Candidate Susceptibility Genes for Rice Blast Resistance Breeding
Authors: Xu Yuchen , Liu Ming-hao , Liu Yanchen , Peng Shasha , Hu Pei , Wang Dan , Yan Shuangyong , Zheng Wenjin , Liu Shiming , Xiao Yinghui , Wang Guo-Liang , Kang Houxiang
Published: August 2021

Traditional rice blast resistance breeding largely depends on utilizing the typical resistance (R) genes. The lack of durable R genes prompts rice breeders to find new source of resistance. The susceptibility (S) genes could be the potentially useful targets for genetic engineering using the cutting-edging genome-editing technologies. However, how to identify S genes is challenging. Here, by combining genome-wide association study and transcriptional analysis, we identified the candidate genes in the rice genome whose expression levels were negatively associated with rice blast resistance. We initially identified five candidate genes by qRT-PCR and comparison of their sequences among the rice blast resistant and susceptible varieties. The obtained results showed that the polymorphisms in 3’ un-translated regions (3’-UTR) of two genes, Os02g39360 and Os08g29170, named RNG1 and RNG3, respectively, were tightly associated with their expression levels and rice blast susceptibility. Subsequently, the negatively association between the expression levels and blast resistance was confirmed using the 3K rice population. Meanwhile, the frequency of the resistance genotype of these two genes was significantly decreased during the first step of rice domestication from wild rice to landrace rice. In contrast, the frequency was increased during the second step of domestication from landrace rice to modern cultivars. Nucleotide diversity analysis found an obvious selective sweep in the surrounding loci of RNG3, means that RNG3 has been artificially selected. The results obtained in this study provide new targets for further gene functional analysis as well as genome editing-based rice blast resistance breeding.
Newborn Screening for Methylmalonic Acidemia/propionic Acidemia: Systematic Evaluation of a Two-pronged Approach Based on MS/MS and UPLC-MS/MS
Authors: Zhou Wei , Song Jinxiu , Li Huizhong , Ji Zhe , Yin Xin , Gu Maosheng
Published: August 2021

Background: An improved second-tier test is needed to reduce the false-positive rate of newborn screening (NBS) for inborn metabolic disorders in Xuzhou, China.Methods: We designed an expanded second-tier assay using newborn dried blood spots (DBSs). Analytical and clinical performance were evaluated in 53 newborns with methylmalonic acidemia (MMA) or propionic acidemia (PA) reported by the Xuzhou Maternity and Child Health Care Hospital NBS program. Additionally, we analyzed NBS data regarding seasonal variation of metabolites, birth weight and gestational age to improve the identification of true positive MMA/PA individuals.Results: Among the 53 MMA/PA individuals assessed, two pathogenic or likely pathogenic (P/LP) variants in an MMA/PA-associated gene were identified in 46 patients, and a pathogenic variant and a variant of unknown significance (VUS) were identified in 7 patients. No such variants were detected in MMA/PA false-positive individuals or healthy controls. Ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based analysis of the initial NBS metabolic profile correctly identified MMA/PA individuals and reduced the initial NBS false-positive rate by 98.86%. MMA/PA false-positive infants in Xuzhou, China, were most likely to be summer-born.Conclusion: We established a two-pronged approach to reduce false positives by nearly 99% and provided a novel NBS strategy. Challenges in neonate metabolic testing and DNA variant interpretation regarding season, birth weight and pregnancy status remain for this Chinese population.
Joint Radiomics Analysis on 18F-FDG-PET-MRI of Primary Tumor to Predict the Risk of Synchronous Distant Metastasis in Pancreatic Ductal Adenocarcinoma
Authors: Gao Jing , Bai Yaya , Miao Fei , Huang Xinyun , Schwaiger Markus , Rominger Axel , Li Biao , Zhu Hui , Lin xiaozhu , Shi Kuangyu
Published: August 2021

PurposeThis study explores the potential of joint radiomics analysis of PET-MRI of primary pancreatic ductal adenocarcinoma (PDAC) tumor in predicting the risk of synchronous distant metastasis (SDM).MethodsTwo cohorts of PDAC patients were collected including a development cohort (n=66) receiving separate 18F-FDG-PET/CT and multi-sequence MRI, and a external test cohort (n=25) receiving hybrid PET/MR. All of these patients were confirmed with SDM after imaging. Radiomics features of primary PDAC tumors were selected and models were built for PET, MRI, and PET-MRI from the development cohort. A radiomics nomogram was constructed by combining independent clinical indicators. The developed radiomics nomogram was independently evaluated on the test cohort. ResultsThe area under the curve (AUC) values of PET, MRI, and joint PET-MRI models were 0.89, 0.86, and 0.94 in the training set and 0.77, 0.67, and 0.77 in the test set. The radiomics nomogram combing the joint PET-MRI radiomics signature, age, and CA19-9 level had good calibration and high discrimination capacity with maximum AUC value (0.93). The decision curve analysis (DCA) confirmed the radiomics nomogram had clinical usefulness. The evaluation on the independent test cohort showed that the accuracy, sensitivity, specificityand AUC values of radiomics nomogram were 84.0%, 78.6%, 90.9% and 0.85.ConclusionThe robust and effective prediction of the risk of SDM for the preoperative PDAC patients confirmed the potential of the radiomics analysis on PET/MR. The radiomics information in primary tumor may provide complementary and alerting hints for cancer staging.
Mimicking skyglow at ecosystem level in a large-scale lake enclosure facility
Authors: Jechow Andreas , Schreck Günther , Kyba Christopher C. M. , Berger Stella A. , Bistarelli Lukas Thuile , Bodenlos Matthias , Gessner Mark O. , Grossart Hans-Peter , Kupprat Franziska , Nejstgaard Jens C. , Pansch Andreas , Penske Armin , Sachtleben Michael , Shatwell Tom , Singer Gabriel A. , Stephan Susanne , Walles Tim J. W. , Wollrab Sabine , Zielinska-Dabkowska Karolina M. , Hölker Franz
Published: August 2021

Light pollution is an environmental stressor of global extent that is growing exponentially in area and intensity. Artificial skyglow, a form of light pollution with large range, is hypothesized to have environmental impact at ecosystem level. However, testing the impact of skyglow at large scales and in a controlled fashion under in situ conditions has remained elusive so far. Here we present the first experimental setup to mimic skyglow at ecosystem level outdoors in an aquatic environment. Spatially diffuse and homogeneous surface illumination that is adjustable between 10 mlx and 10 lx, resembling rural to urban skyglow levels, was achieved with white light-emitting diodes at a large-scale lake enclosure facility. The illumination system was enabled by optical modeling with Monte-Carlo raytracing and validated by measurements. Our method can be adapted to other outdoor and indoor skyglow experiments, urgently needed to understand the impact of skyglow on ecosystems.
A comparative account of biogenic synthesis of silver nanoparticles using in-house potential probiotics and their antimicrobial activity against challenging antibiotic resistant pathogens
Authors: SHARMA SHAKSHI , SHARMA NIVEDITA , KAUSHAL NEHA
Published: August 2021

The present work focusses on development of a safe, inexpensive, and more accessible source for biosynthesis of silver nanoparticles. Four different in-house probiotic isolates i.e., Lactobacillus pentosus S6, Lactobacillus plantarum F22, Lactobacillus crustorum F11 and Lactobacillus paraplantarum KM1 isolated from different food sources, were used in the current study to check their ability to synthesize silver nanoparticles. All the probiotics synthesized silver nanoparticles shows maximum Surface Plasmon Resonance (SPR) at a peak of 450 nm, which confirms the formation of silver nanoparticles. Scanning Electron Microscopy (SEM) analysis identified the shape and distribution of silver nanoparticles. Transmission Electron Microscopy (TEM) revealed the average size of synthesized nanoparticles in the range of 10-50 nm, with smallest size of 5 nm for silver nanoparticles synthesized by L. crustorum F11. Further, Fourier-transform infrared spectroscopy (FTIR) detected the presence of different functional groups responsible for reduction of silver ion to form silver nanoparticles. The antimicrobial activity of these AgNP was also found to be effective against different bacterial and fungal pathogens viz. antibiotic resistant Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes , Pythium aphanidermatum , Fusarium oxysporum and Phytopthora parasitica . However, L.crustorum F11 synthesized AgNP showed maximum inhibition against all the bacterial and fungal pathogens, with highest against S. aureus (20 0.61mm) and F. oxysporum (23 ). Findings from this study provide a durable and ecofriendly method for the biosynthesis of silver nanoparticles, having strong antimicrobial activity against different multidrug resistant microorganisms.
Gut microbial diversity and composition of Indian white shrimp (Penaeus indicus)
Authors: Patil Prasanna Kumar , TN Vinay , Ghate Sudeep Darbhe , Baskaran Viswanathan , Avunje Satheesha
Published: August 2021

The endemic Indian white shrimp (Penaeus indicus) is an economically important shrimp species, distributed in the Indo-West Pacific region. Knowledge of gut microbial composition helps in dietary interventions to ensure improved health and production. Here we analyzed V3-V4 hypervariable regions of the 16S rRNA gene to examine intestinal microbiota in the wild and farmed P. indicus. The study revealed Proteobacteria, Fusobacteria, Tenericutes, and Bacteroidetes, were the dominant phyla in both the groups; though the differences in relative abundance were evident. The dominant genera in case of the wild group were Photobacterium (29.5%) followed by Propionigenium (13.9%), Hypnocyclicus (13.7%) and Vibrio (11.1%); while Vibrio (46.5%), Catenococcus (14%), Propionigenium (10.3%) and Photobacterium (8.7%) were dominant in the farmed group. The results of the study suggest the role of environment on the relative abundance of gut bacteria. This is the first report characterizing gut microbial diversity in P. indicus, which can be used to understand the role of gut microbiota in health, nutrition, reproduction, and growth.
Effects of COVID-19 lockdown on managing diabetes mellitus among Sudanese insulin pump users, A study from Sudan
Authors: Salih Esraa Hassan , Ahmed Khabab Abbasher Hussien Mohamed , Omer Mohammed Eltahier Abdalla , Babiker Omer Osman , Mohamed Malaz Tarig Abdalla , Salih Zeinab Mohammed Amara
Published: August 2021

Background: COVID-19 lockdown has affected diabetes management among the insulin pump users by changing their life style, affected their mental health, limited diabetes and insulin pump supplies and more difficult communication with the healthcare providersObjectives: The aim of this research is to study the effects of COVID-19 lockdown on managing diabetes mellitus among Sudanese insulin pump users, SudanMethods: This study was a descriptive cross-sectional study, Community based in Shimaa medical CO. LTD. A 26 insulin pump users were chosen by total coverage and the data was collected throughout phone call interviews. All statistical analyses were performed using IBM SPSS Statistics software, version 20.Results: The mean age of 22 participants was 25.3 ± 17.2 years, and the majority (63.6%) were females. The average duration of diabetes was 6.9 ± 3.9 years, and the average duration of insulin pump use was 3 ± 1 years. Of the 22 patients (90.9%) used glucometer for monitoring blood sugar. 9 (40.9%) were less subjective to depression, 9 (40.9%) had moderate susceptibility to have depression. Most of the patients have unchanged adherence to the insulin pump behaviours, carb counting (63.6%), boluswizard during mealtime (68.2%), and bolus wizard for hyperglycemia correction (68.2%), self-monitoring of blood glucose (40.9 %). (40.9%) of the patients had scheduled phone call appointments, 5 patients (22.7%) received virtual education (VE) from the insulin pump technician. 12 patients (54.5%) reported difficult obtaining at least one type of insulin pump supply.Conclusion: COVID-19 lock down has led to the decrease in physical activity with unchanged dietary habits. Getting the insulin pump supplies was difficult for most of the patient’s, and there was shortage and increase prices for diabetes care supplies. Telemedicine should be considered seriously to ease the communication between the patients and the health care providers.
Analogous Hawking radiation in butterfly effect
Authors: Morita Takeshi
Published: August 2021

We propose that Hawking radiation-like phenomena may be observed in
systems that show butterfly effects. Suppose that a classical dynamical
system has a Lyapunov exponent \lambda_LλL,
and is deterministic and non-thermal (T=0T=0).
We argue that, if we quantize this system, the quantum fluctuations may
imitate thermal fluctuations with temperature $T _L/2 $ in a
semi-classical regime, and it may cause analogous Hawking radiation. We
also discuss that our proposal may provide an intuitive explanation of
the existence of the bound of chaos proposed by Maldacena, Shenker and
Stanford.
Conectados +, experiencia educativa en la covidianidad. Reinventando entornos virtuales de aprendizaje en la Comunicación
Authors: López Aguirre José Luis
Published: August 2021

La transición a la educación en línea en tiempos del coronavirus ha implicado no sólo el desarrollo de nuevas habilidades y actitudes sino la explosión de la creatividad de infinidad de profesores. De pronto, los maestros nos convertimos en aprendices de magos, y tuvimos que adaptarnos e innovar. Particularmente tuvimos que aprender a descubrir nuevas posibilidades que nos permitiesen cocrear con nuestros estudiantes un rico ecosistema de experiencias de enseñanza-aprendizaje durante la covidianidad. En consecuencia, el objetivo del presente artículo es compartir la experiencia de aprendizaje de la gestión del modelo educativo en línea que hemos bautizado como Conectados +. Por supuesto, se exponen, con el permiso de mis estudiantes, algunas estrategias, dinámicas y actividades de interacción, cocreación y evaluación como la aplicación de un examen en díadas, en la nube y en red, sustentado en la teoría del conectivismo; así como la apropiación y articulación de un conjunto de plataformas (Zoom, Google Drive, Twitter y YouTube) y recursos tecnológicos (Jamboard, Kahoot!, Poll Everywhere y Pinpoint) que conforman el ecosistema de experiencias de enseñanza-aprendizaje de Conectados +.
Hernán Cortes online. Rasgos físicos y de carácter del conquistador. Modelo de lectura crítica multimedia en línea para estudiantes universitarios
Authors: López Yepes José
Published: August 2021

Este artículo contiene el texto básico de un curso en línea sobre el tema mencionado en el título del mismo y se realiza en el ámbito de un proyecto de investigación de carácter internacional emprendido por la Universidad Panamericana de México. El artículo se completa con los contenidos de una plataforma GOOGLE DRIVE accesible en línea en https://drive.google.com/drive/folders/1kbZFH2Kdq6qJ1Vd_aO8oe-XE6ymqDSWJ?usp=sharing para enseñanza a distancia formada principalmente por materiales didácticos, ejercicios del estudiante, repositorio y proyectos de investigación conjuntos docente/alumnos. El objetivo es que el alumno, mediante el método de la lectura crítica, desarrolle el pensamiento crítico comparando diversas versiones sobre los rasgos físicos y de carácter de Cortés a fin de aprender historia de Nueva España y alcanzar criterios personales sobre la cuestión. Para ello, introducimos la teoría de la lectura crítica, identificamos los rasgos físicos y modos de ser de Cortés y presentamos los testimonios de los cronistas de la época y los videos y filmes que han interpretado con posterioridad dichos rasgos y modos de ser.
Ficción/no ficción en 11M.
Authors: Bellido Acevedo Gema
Published: August 2021

El presente artículo analiza la miniserie española 11M, para que nadie lo olvide, basada en los ataques terroristas producidos en Madrid en 2004, como un ejemplo de la hibridación entre la ficción y la no ficción tan presente en los relatos audiovisuales contemporáneos. Con base en la metodología del análisis textual, así como una entrevista con el guionista, se presentan los hallazgos del análisis que apuntan a un trabajo de reconstrucción histórica y ficcionalización durante la producción que da como resultado un relato audiovisual que articula recursos narrativos de ambos géneros, diluyendo las fronteras entre lo factual y lo ficticio.
Videos de relatos de viaje y guías didácticas para el estudio de la ruta de Hernán Cortés desde Veracruz hasta México-Tenochtitlan (1519)
Authors: López Hernández Alfonso , Suárez Ramírez Sergio , López Yepes Alfonso
Published: August 2021

El presente texto es uno de los resultados del proyecto de investigación Modelo de lectura crítica. La aventura de Hernán Cortés hace 500 años. El camino de Nueva España (De Cozumel al estado de Puebla) financiado por la Universidad Panamericana, México, para el período 2019-2020 a un equipo formado por profesores investigadores de la citada Universidad y de diversas universidades. En dicho texto, incluido en un blog elaborado por el Dr. López Hernández, se ofrece un panorama general del viaje que los autores del proyecto siguieron en la ruta de Cortés y ofreció como frutos más destacados los relatos de las distintas etapas, el relato del viaje complementario efectuado por el Dr. A. López Yepes y una muestra de las guías didácticas (actualmente en prensa) elaboradas por el Dr. Suárez Ramírez.
CHALLENGES OF TIO2-COMPOSITE, AS A VISIBLE ACTIVE PHOTOCATALYST MATERIAL FOR SARS-COV-2 ANTIVIRAL COMPARED WITH THE OTHER VIRUSES
Authors: Eddy Diana , Permana Muhamad , Lutfiah Annisa , Noviyanti Atiek , Deawati Yusi , Rahayu Iman
Published: August 2021

The efforts in dealing with COVID-19 in various aspects are continuously being carried out, such as the photocatalytic process. Interestingly, TiO2 plays an important role as an environmentally friendly photocatalyst with a visible and UV absorption range. The increase in the antiviral performance of this compound is further maximized by formulating TiO2-based composites and doping it to reduce the bandgap. This review aims to determine the challenges of TiO2-based composite as a visible active photocatalyst material for SARS-CoV-2 antiviral. It presents a discussion of the photocatalytic function of TiO2, by comparing the secondary data obtained from viruses that have been successfully degraded by the SARS-CoV-2. The literature search led to the analysis of the photocatalyst quality, structure, composition, and the degraded viruses. This comparison was based on the photocatalyst’s general constituents, such as protein and RNA. The virus morphology as observed in the secondary data was successfully destroyed by hydroxyl radicals resulting from the photocatalytic processes. It was observed that TiO2 photocatalyst generated ROS, capable of inactivating various viruses, therefore, it has the potential in fighting against the SARS-CoV-2. Moreover, further research is needed in photocatalyst design, its role, and the overall mechanism of virus inactivation.
PREPARATION OF FLUORESCENT POLYSTYRENE MICROSPHERES BY IMPROVING SWELLING PERFORMANCE BASED ON MOLECULAR WEIGHT AND SURFACE CARBOXYL GROUP CONTENT
Authors: Sun Fei , Feng Chao , Wang Yang , Yang Xue , Zhao Hong
Published: August 2021

The fluorescent microspheres are prepared by the swelling-evaporation method. The optimal swelling conditions are obtained by researching related factors, such as types and dosages of swelling agent, dosages of fluorescent substance, swelling time and swelling temperature. Considering that the structure of microspheres can influence the swelling properties, the paper mainly focuses on the effect of molecular weight and surface carboxyl group content of polystyrene microspheres on swelling properties. When the molecular weight of microspheres is 75276 g mol-1, the density of carboxyl group on their surface is 6.94×10-4 mol g-1, and the doping amount of europium complex reaches the maximum of 24.9 mg g-1 with the strongest fluorescence intensity. Meanwhile, the as-prepared fluorescent microspheres have high monodispersity, uniform particles size and high thermal stability (the decomposition temperature is 385 oC), which sets up the good foundation for biomolecule detection. So, this work provides a significant experience for the preparation of fluorescent microspheres.
Analysis model of restoring force of a rubber air spring
Authors: Vo N. Y. P. , Le T. D.
Published: August 2021

Not only has the dynamic stiffness of a rubber air spring been inherited by effects of the compressed air, but it has also been affected by hysteresis behaviors caused by the friction, viscoelasticity of bellow material. Hence, this paper will analyze comprehensively the stiffness model of a commercial rubber air spring. One of the first works is to predict the structure parameters including effective area, volume and their change rate. Then, the restoring force generated by compressed air will be analyzed and built through the theory of thermodynamics. The hysteresis model of the rubber bellow will be obtained based on the Berg’s frictional model connecting in parallel with fractional Kelvin-Voigt model. Next, an experimental apparatus is set up to identify the parameters of this model as well as evaluate the proposed restoring force model of the rubber air spring. The study results show that the analysis model of the rubber air spring matches well the measured data. This work will offer a helpful insight in the design of the vibration isolation system using rubber air springs as elastic elements.
Human Capital: Diagnostics and Development Direction
Authors: Gryaznova Natalya , Pleshkova Nataliya , Podzorova Galina A , Muhacheva Anna , Drapkina Galina
Published: August 2021

Human capital is the most important development factor of an innovative economy. Managers at all levels are beginning to recognize the importance of human qualities and skills, as well as the need for their development. The present research diagnozed the state of human capital of the Kemerovo Experimental Mechanical Repair Plant. The paper outlines the theoretical and methodological foundations of human capital, introduces some prospects for its development, analyzes staffing and HR processes, assesses the current system of motivation and remuneration, measures the cost of the human capital, and evaluates all its elements, namely education, culture, and health. A sociological questionnaire made it possible to assess the satisfaction from labor conditions and management, as well as the level of motivation. The authors offer some improvement measures for the development of the human capital within the enterprise in question.
PR-Promotion of a Recreational Organization
Authors: Rozova Natalia , Nesmelova Arina
Published: August 2021

The article introduces some PR-promotion opportunities for the greenhouse complex of the Tauride Garden (St. Petersburg), which provides a unique historical platform for recreational activities and leisure time. The research featured PR-promotion techniques that can be employed by organizations of leisure and recreation, especially when targeting foreign audience. The author defined key characteristics inherent to leisure organizations and the features of their PR-promotion. The paper contains a SWOT analysis, a review of media statistics, a search profile, and an analysis of the best foreign and Russian practices. The study also involved a survey conducted among foreign citizens visiting St.Petersburg, which made it possible to determine their awareness of the leisure opportunities offered by the Tauride Garden and assess the related level of satisfaction. The author proposes a number of recommendations for PR-promotion of the greenhouse complex of the Tauride Garden among foreign visitors.
Management of Congress and Exhibition Activities at the University
Authors: Stepanova Antonina
Published: August 2021

Congress and exhibition activities are an effective means of promoting scientific and innovative development in institutions of higher education. The present research objective was to identify the main problems of managing congress and exhibition activities at universities. The paper focuses on various problems relevant for technical universities of Saint-Petersburg. It describes the experience of Peter the Great Polytechnic University, Saint-Petersburg Mining University, and the National Research University of Information Technologies, Mechanics, and Optics. The author compiled a list of recommendations and principles of management to be used by technical universities when organizing congresses and exhibitions. The proposed model covers different approaches to congress activities, forms of scientific activity, management structure of international services, and regulatory documents. Universities have neither regulatory framework nor separate service responsible for this type of activity. Students, employees, and most academics lack necessary skills in foreign languages and cross-cultural communication. Moreover, they do not get motivational and stimulating support, hence the lack of initiative. Students and academics receive little information about scientific events. Most employees simply do not know how to organize congresses and conferences. This network of problems needs a comprehensive approach.
GEOGEBRA PARA O ENSINO DE FUNÇÃO POLINOMIAL NA PERSPECTIVA DA AÇÃO MEDIADA
Authors: Gomes Arianne Vellasco , Lucas Rodrigo Dantas de , Souza Aguinaldo Robinson de , Marques Emília de Mendonça Rosa
Published: August 2021

Neste artigo apresentamos um trabalho desenvolvido com licenciandos calouros em Matemática, no qual, buscou-se a produção de significados através do desenvolvimento de uma sequência didática proposta utilizando o software GeoGebra, visando a análise do nível de domínio e de apropriação dos conceitos de funções polinomiais de uma variável real. A análise dos dados coletados está fundamentada na teoria da ação mediada de James Wertsch, a qual tem como foco o estudo sociocultural da mente e a memória coletiva sobre os aspectos históricos mediados pelas ferramentas culturais concernentes às instituições formais de ensino. O público alvo consistiu em nove (9) estudantes, sendo cinco (5) do sexo masculino e quatro (4) do sexo feminino, do curso de Licenciatura em Matemática da Universidade Estadual Paulista - UNESP, em Bauru, São Paulo, Brasil. A pesquisa, de caráter qualitativo, pode ser caracterizada como um estudo de caso, visto que envolveu a busca por significados atribuídos aos sujeitos da pesquisa relativos às suas vivências e experiências pessoais. As atividades desenvolvidas com o software de geometria dinâmica e as reflexões solicitadas na sequência didática contribuíram para a experimentação, a criação de estratégias, a produção de conjecturas, a argumentação qualitativa e a dedução de propriedades matemáticas relativas aos conteúdos destas funções de uma variável real. Os licenciandos com maior base teórica em Matemática foram capazes de explorar os recursos computacionais com maior destreza, acuidade e precisão, conseguindo assim, maior aprofundamento nos conteúdos por eles explorados. Esses alunos apresentaram, ainda, um detalhamento com bom nível de rigor matemático em suas explicações sobre os conteúdos abordados, cometendo poucos erros de notação simbólica.
Ódio ao STF e às Universidades Públicas: aplicação da ADPF 572 (caso das fake News) para proteção da comunidade acadêmica
Authors: Ferreira Emanuel Melo
Published: August 2021

O presente artigo busca responder à seguinte indagação: é possível sustentar a aplicação do precedente firmado pelo Supremo Tribunal Federal no caso de fakenews em casos envolvendo calúnia, injúria ou difamação contra grupos que compõem as Universidades? Tenta-se demonstrar como a ocorrência de crimes contra a honra contra grupos acadêmicos apresenta semelhança relevante em prol da aplicação do mencionado precedente, pois nele se buscava proteger juízes de ataques semelhantes. O contexto de tais crimes é salientado a partir do autoritarismo populista com marcas anti-intelectuais, atraindo considerações em torno da democracia militante a partir da utilização de um precedente como mecanismo de defesa institucional também no contexto educacional. Conclui-se sustentando que as razões de decidir do precedente apontam semelhanças entre os casos são mais relevantes que as diferenças, sendo correta a aplicação do precedente para as diversas situações envolvendo danos morais coletivos a alunos e professores de tais instituições.
A urgência de uma pedagogia antirracista: impactos da incorporação do art. 4, X, da nova Convenção Interamericana contra o racismo ao ordenamento jurídico brasileiro
Authors: Bezerra Sérgio , Oliveira Thiago , Medeiros Enzo
Published: August 2021

O presente trabalho trata do combate ao racismo e à discriminação racial pelo sistema interamericano de proteção aos direitos humanos. Nesse contexto, são abordadas questões referentes ao art. 4, X, da Convenção Interamericana contra o Racismo, a Discriminação Racial e Formas Correlatas de Intolerância. Verifica-se, ainda, se a incorporação do texto convencional no Brasil irá efetivar um aumento na proteção das populações não-brancas em situação de desamparo. Esse estudo, assim, contribui com a agenda de pesquisa no compromisso da erradicação de práticas discriminatórias pelo Estado brasileiro. Outrossim, tem o objetivo de fomentar a igualdade jurídica pela aplicação do artigo mencionado. Foram utilizados, para tanto, a revisão bibliográfica sobre direitos humanos e racialidade e a análise jurisprudencial, bem como o estudo de casos. Conclui-se, pois, que a incorporação da referida Convenção, se interpretada a partir de pressupostos teóricos raciais legítimos, em especial no que se refere à produção de ferramentas pedagógicas antirracistas, trará um importante fortalecimento no combate ao racismo no país, o que demanda um esforço, inclusive, dos agentes encarregados pela aplicação do texto do tratado.
Alguns apontamentos acerca da substituição das profissões jurídicas por máquinas
Authors: Pessoa Daniel Alves
Published: August 2021

Neste artigo, trabalhou-se a conclusão do item III.2 do sumário executivo da pesquisa qualitativa “tecnologia, profissões e ensino jurídico”, desenvolvida pelo Centro de Ensino e Pesquisa em Inovação (CEPI) da Escola de Direito da Fundação Getúlio Vargas de São Paulo (FGV Direito SP), cujo texto-síntese foi: “substituição por máquinas se concentra em cargos de hierarquia mais baixa”. Foi utilizada a análise do discurso para o tratamento do tema, conforme o referencial teórico de Eni Puccinelli Orlandi. Nesse desiderato, foram agregadas as relações com outros discursos, a partir dos paradigmas da tecnologia da informação da sociedade em rede de Manuel Castells e da sociologia das profissões jurídicas de Maria da Glória Bonelli, das perspectivas de Richard e Daniel Susskind acerca do futuro das profissões, e de Vittorio Frosini sobre cibernética, direito e sociedade, além de outras análises sobre as relações da tecnologia da informação com o campo jurídico. Foi possível encontrar outra atribuição de sentido para o discurso manifestado no texto, sem, contudo, desconstituir o que foi dito.
O discurso especializado em artigos de investigação médica: Uma comparação linguística entre o inglês e o galego
Authors: Zas María Fernández
Published: August 2021

Devido ao notável desenvolvimento da ciência e da tecnologia nos últimos tempos, o inglês tornou-se a língua principal para a transmissão de conhecimentos especializados. Pelo contrário, na Galiza, o estudo do discurso de especialidade permaneceu em grande parte inexplorado até ao final do século passado, quando o galego alcançou o estatuto de língua co-oficial dentro do Estado espanhol. Este artigo apresenta uma abordagem analítica e descritiva da noção de discurso especializado com três objetivos. Em primeiro lugar, tenta clarificar o conceito acima mencionado, bem como os seus traços distintivos, afim de identificar potenciais diferenças e semelhanças em termos de como os especialistas pertencentes aos mundos anglófono e galegófono compreendem e utilizam as línguas de especialidade. Em segundo lugar, pretende, baseada em corpus, realizar uma comparação quantitativa e qualitativadas caraterísticas morfossintáticas mais relevantes do discurso especializado em inglês e em galego, com particular incidência no campo da escrita médica. Finalmente, este artigo tenciona também preencher uma lacuna significativa nos estudos linguísticos galegos, onde a investigação sobre as línguas de especialidade continua a ser uma questão pendente. Para atingir estes objetivos, leva-se a cabo uma comparação linguística do discurso especializado em inglês e em galego com base em vinte e quatro artigos de investigação, através dos quais as caraterísticas morfossintáticas mais representativas dos textos especializados são analisadas, interpretadas e discutidas em profundidade para ambas as línguas. Os resultados revelam que as línguas de especialidade em inglês e em galego apresentam muitas mais semelhanças do que seria inicialmente expectável, sendo as diferenças mais notáveis as inerentes às especificidades de cada sistema linguístico.