bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS EOQ DAN PENERAPAN JUST IN TIME (JIT) DALAM MANAJEMEN PERSEDIAAN BAHAN BAKU MEBEL DI PERSADA KUSEN TASIKMALAYA
Authors: Rizzal Maulana Ardhanariswara Syahrul , Kusuma Ningrat Nugraha , Kurnia Yusup
Published: April 2024

Persada kusen merupakan salah satu perusahaan yang bergerak dalam bidang pembuatan mebel. penggunaan metode EOQ dan penerapan JIT dalam manajemen persediaan bahan baku mebel memiliki potensi untuk meningkatkan efisiensi operasional dan mengurangi biaya penyimpanan. Kedua metode ini dapat membantu perusahaan mebel dalam mengoptimalkan ukuran pesanan, menghindari kekurangan atau kelebihan persediaan, dan meningkatkan aliran material untuk memenuhi permintaan produksi secara tepat waktu.

Rumusan masalah pada penelitian ini yaitu bagaimana persediaan bahan baku di persada kusen tasikmalaya dan bagaimana persediaan bahan baku di persada kusen tasikmalaya menggunakan EOQ (Economic Order Quantity).

Metode yang digunakan untuk menjadi sokusi permasalahan tersebut yaitu EOQ dan JIT. Dalam penelitian ini bertujuan untuk meminimalkan biaya penyimpanan dan biaya pesanan.

penelitian ini dilakukan dengan membandingkan biaya persediaan tahun 2022 yaitu sebesar Rp.3.033.000 dan hasil penelitian terdapat pengurangan dari hasil penelitian ini yaitu menggunakan metode EOQ Maka perusahaan mebel persada kusen bisa meminamalisir penggunaan biaya untuk pengadaan bahan baku sebesar Rp. 937.0316,- dan menggunakan metode JIT sebesar Rp. 1.551.126.
It's OK to Move! Effect of a Brief Video on Community Confidence in Activity Despite Back Pain: A Randomized Trial
Authors: O'Hagan Edel T. , Traeger Adrian C. , Schabrun Siobhan M. , O'Neill Sean , Wand Benedict M. , Cashin Aidan G. , Williams Christopher M. , Harris Ian A. , McAuley James H.
Published: April 2024

OBJECTIVE: To estimate the difference in confidence to become active despite low back pain in people who were exposed to one of 2 video interventions delivered on social media, compared to no intervention.

DESIGN: A proof-of-concept, 3-group randomized controlled trial, in a 1:1:1 ratio.

METHODS: Participants aged 18 years and over, with and without low back pain, were recruited via the social media channel Facebook, to view either a humorous video, a neutral video, or to no intervention. The videos were delivered online, explained evidence-based management for low back pain, and were designed to “go viral.” The primary outcome was confidence in becoming active despite pain, measured using the Pain Self Efficacy Questionnaire (Item 10) (ranges from 0 [not at all confident] to 6 [completely confident]) immediately after watching the video. We aimed to capture the real-time impact and immediate reactions that contributed to the content's reach.

RESULTS: Among 1933 randomized participants (mean [standard deviation] age: 58.9 [14.0] years, 1285 [75%] women), 1232 [70%] had low back pain and 88.8% completed the primary outcome. One thousand two hundred sixty-four participants were randomized to receive a video intervention, and 633 participants did not receive a video. On a 6-point scale, individuals exposed to either video (n = 1088) showed a mean confidence level 0.3 points higher (95% confidence interval: 0.1, 0.6) compared with no video (n = 630).

CONCLUSION: Participants who viewed a brief video intervention reported a very small difference in confidence to become active despite low back pain, compared with no intervention. The difference may lack clinical relevance. J Orthop Sports Phys Ther 2024;54(6):400-407. Epub 18 April 2024. doi:10.2519/jospt.2024.12412
Research of Quadrupole Lenses for Ions Transport Channel
Authors: Bykov S. A. , Vostrikov V. A. , Zhilyaev K. V. , Morozov I. I. , Okunev I. N. , Pakhomov A. Yu.
Published: April 2024

In Budker Institute of Nuclear Physics SB RAS the magnetic elements of transfer channel for charged particle beams from SIS18 to SIS100 (FAIR, Germany) [1] were developed. The article presents a description of the quadrupole magnet Q2 and serial magnetic measurements results. Magnetic measurements with application of rotating harmonic coil and moving carriage with linear array of Hall sensors were taken. Quadrupole lenses provide magnetic field integral gradient with high quality (<5·10-3) and satisfy the requirements. High order harmonics are present in the magnetic field due to manufacturing and assembly errors and can imperfect on beam dynamics. Main attention was considered to the third (sextupole) harmonic amplitude, determinate the chromatic properties of the lens. It allows select manufactured magnets to distortion value and minimize imperfection of beam dynamics by optimal theirs arrangement.
Non-Destructive Single-Revolution Electron Beam Profilometer based on a CCD Camera
Authors: Timoshenko M. V. , Perevedentsev E. A. , Sherstyuk S. P.
Published: April 2024

CCD cameras are easy to use and are quite widespread in the optical diagnostics of beams in particle accelerators. The exposure time of these cameras is milliseconds, so they are usually used in a cumulative mode to monitor the circulating beams. The images from the cameras contain information about the transverse distribution of particles in the beam and the position of the center of mass of the beam. In this paper, using the example of CCD cameras installed on the electron-positron collider VEPP-2000, the possibility of their use in the mode of a single beam flight through the observation site is investigated. The intensity of the luminous flux of the optical part of the synchrotron radiation spectrum of the beam was estimated and an image of the transverse distribution of particles in the beam in a single-span mode was experimentally obtained, which confirms the potential for expanding the scope of this diagnostic system. A trial signal processing was done as a demonstration of the determination of the beam parameters by the method under study.
Dosimetry of Neutron Flow and Gamma-Radiation for two Neutron Beam Shaping Assembly at the VITA Facility using a Scintillator Detector
Authors: Ibrahim I. S. , Bykov T. A. , Kolesnikov I. A. , Sokolova E. O. , Sycheva T. V. , Verkhovod G. D. , Shchudlo I. M. , Kuznetsov A. S. , Bikchurina M. I. , Koshkarev A. M. , Kasatov D. A. , Porosev V. V. , Taskaev S. Yu.
Published: April 2024

The BNCT method is considered one of the promising methods of external beam therapy in the treatment of radioresistant tumors such as glioblastoma, melanoma and others, which selectively destroy cancer cells due to previous accumulations of boron-10 isotopes stable inside them, and subsequent irradiation with epithermal neutrons. As a result of neutron capture by boron, nuclear radiation interacts with the release of a large amount of energy (charged particles with a high linear energy transfer), which leads to the destruction of the cancer cell. This method is distinguished by a short number of treatment sessions compared to traditional radiation therapy (photons and electrons). In this study, the boron dose rate and the dose rate of gamma radiation in air and in a water phantom are measured using a small-sized neutron detector with a pair of cast polystyrene scintillators, one of which is enriched with boron, developed at BINP. Two neutron beam shaping assembly were used, one with a magnesium fluoride crystal moderator and the other with a Plexiglas moderator. The article will present the experimental results, discuss the features of the neutron beam shaping assembly and formulate recommendations for conducting clinical trials of the BNCT technique
Prevalência do uso e experimentação de cigarro eletrônico por acadêmicos em uma faculdade de medicina do Tocantins
Authors: Gomes Gabriel Chaves , Ibiapina Irving Rodrigo de Sousa , Soares Josefran Vinicius Duarte , Sousa Valdete Andrade , Zeckowski Marília
Published: April 2024

Objetivo: Identificar a prevalência do uso e experimentação de cigarros eletrônicos entre estudantes de medicina, bem como investigar os fatores que influenciam o uso desses dispositivos e o nível de conhecimento sobre o tema. Métodos: Estudo epidemiológico observacional descritivo, abordagem quantitativa e qualitativa com estudantes do 1º ao 12º período. Os dados foram coletados através de um formulário eletrônico com variáveis sociodemográficas, hábitos de vida e caracterização do uso do cigarro eletrônico. Foram analisados os dados, estatisticamente, para verificar a associação entre as variáveis por meio de Regressão Logística Binomial. Resultados: A amostra consistiu em 151 participantes regularmente matriculados, envolvendo majoritariamente o sexo feminino (60.3%), com idades entre 18 e 25 anos (74.20%), solteiros (82.8%) e heterossexuais (88.1%). Quase todos os participantes (99.3%) já conheciam sobre cigarros eletrônicos, principalmente devido à influência da mídia informal. Apenas o gênero correlacionou-se com o uso, com homens usando o dobro das mulheres. Cerca de 55% experimentaram vapers, sendo 25% usuários diários e 79.17% relataram adversidades, principalmente respiratórias. Conclusão: Conclui-se uma alta prevalência do uso de cigarros eletrônicos, especialmente do sexo masculino, ressaltando a importância da educação formal sobre os riscos e a necessidade de regulamentações mais rigorosas.
Morfofisiologia da pele e o processo de envelhecimento cutâneo
Authors: Silva Natan Cordeiro da , Bezerra Bruno José da Silva , Simão Estefani Pontes , Tenório Fernanda das Chagas Angelo Mendes , Aragão Neto Adelmo Cavalcanti , Santos Noemia Pereira da Silva , Correia Maria Tereza dos Santos , Andrade Fernanda Miguel de
Published: April 2024

Objetivo: Este trabalho objetivou descrever a morfofisiologia da pele e o processo do envelhecimento cutâneo. Revisão bibliográfica: A pele é o maior órgão do corpo humano e além de proteção, desempenha diversas funções fisiológicas. Com o passar dos anos, tende a entrar no processo de envelhecimento natural, porém, alguns agentes externos ao corpo podem acelerar esse envelhecimento e provocar um aparecimento antecipado das rugas e flacidez, característicos do envelhecimento. Os sinais e características do envelhecimento da pele se dão principalmente pela degradação das fibras de colágeno, onde sua ausência provoca uma perda de preenchimento da matriz extracelular e a perda das fibras elásticas, fazendo com que o tecido perda elasticidade. Considerações finais: Entre os fatores indutores extrínsecos ao corpo, estão a exposição aos raios solares, tabaco, poluição e má alimentação, esses fatores, levam a formação de espécies reativas de oxigênio e essas espécies ativam cascatas de reações que degradam fibras de colágeno e fibras elásticas induzindo assim o envelhecimento precoce da pele.
In-vitro and In-vivo Studies of Anti-inflammatory Potential of Compounds Derived from Piper mullesua
Authors: Arvinder Kaur , VK Sohpal , Zabeer Ahmed , Diksha Saroch
Published: April 2024

The identification and development of new anti-inflammatory drugs continue to benefit greatly from the use of natural substances and their synthetic counterparts. Studies have been conducted on a compounds obtained from the Piper mullesua plant. The current work aims to use in-vitro and in-vivo experiments to investigate these substances’ anti-inflammatory properties. Our investigation’s findings showed that various substances had varying percentages of cell viability on RAW 264.7 cells. These substances were also tested for suppression of nitric oxide. Novel approaches to the creation of pharmaceuticals have demonstrated the potential of natural product derivatives. This study set out to investigate PM208-209’s potential anti-inflammatory properties. The impact of PM208-209 on inhibiting tumor necrosis factor-alpha (TNF-α) and IL-6 in LPS-induced RAW 264.7 cells was examined using enzyme-linked immunosorbent assay (ELISA). Additionally, PM208-209 demonstrated anti-inflammatory effects in mice, as evidenced by the suppression of vascular permeability and migration of leukocytes. The information gathered suggested that PM208-209 should be investigated further in terms of pharmacological research and could be regarded as a possible therapeutic anti-inflammatory option
Pharmacognostical and Phytochemical Evaluation of Antihyperlipedemic Polyherbal Formulation
Authors: Agrawal Ankur , Dubey Subodh K
Published: April 2024

Cardiovascular diseases, particularly hyperlipidemia, remain a significant global health concern, prompting the need to investigate alternative therapeutic approaches. This research focuses on the pharmacognostic and phytochemical evaluation of an innovative polyherbal formulation developed for its potential antihyperlipidemic properties. The pharmacognostic assessment thoroughly examines the morphological, microscopic, and macroscopic characteristics of the individual plant constituents utilized in the formulation. Additionally, organoleptic properties were utilized to set quality parameters. Subsequent phytochemical analysis aimed to recognize and enumerate bioactive moities present in the formulation. Customary procedures were employed to levy the charisma of alkaloids, flavonoids, phenolic compounds, saponin, terpenoids, and other secondary metabolites recognized for their therapeutic potential. Antioxidant assays were conducted for both individual components and the herbal tablet. The study delves into the synergistic interactions among the constituents to pinpoint and quantify specific chemical compounds responsible for the antihyperlipidemic effects. The outcome of this analysis offer broad indulgence of polyherbal formulation’s pharmacognostic and phytochemical traits, laying the groundwork for its therapeutic potential in managing hyperlipidemia.
Unveiling Cytotoxic Potential of Herbal Extracts: Plectronia parviflora and Agave cantula against MCF and HCT Cell Lines
Authors: Cheruku Sandeep R , SM Shaheedha
Published: April 2024

Cancer is a global health challenge that requires novel therapeutic approaches. This study investigates hydroalcoholic extracts and compounds isolated from Plectronia parviflora and Agave cantula. Using them as cancer therapies will shed light on their potential as cytotoxic agents. Microscopic confirmation of complete dissociation followed DMEM medium supplemented with 10% FBS cultivation of HCT-15 and MCF-7 cell lines. As controls, cells were introduced without samples at varying concentrations. After the medium was removed, a 24-hour incubation was followed by rinsing the cells in PBS. Trypan blue stain (0.4%) was used to determine cell viability. Upon introducing cells to fresh medium, triplicate samples were introduced. After 18 hours of incubation at 37 ± 1°C, MTT (mg/mL) was added to all wells and incubated for an additional 4 hours. Subsequently, DMSO was introduced, and absorbance readings were taken at 570 nm using a photometer. Cytotoxicity and cell viability were calculated using established formulas. Cytotoxicity analysis revealed distinct patterns in both HCT-15 and MCF-7 cell lines. Among the extracts, hydroalcoholic extracts of P. parviflora exhibited notable cytotoxicity, with IC50 values of 108.46 and 133.37 μg/mL for HCT-15 and MCF-7, respectively. A. cantula extracts displayed variable cytotoxicity, with IC50 values 115.35 and 115.94 μg/mL for HCT-15 and MCF-7. Notably, isolated compounds from these plants exhibited unique cytotoxic profiles with IC50 values of IF-PL-57.82 and 53.72 mg/mL and IF-AC-72.81 and 72.36 mg/mL for HCT-15 and MCF-7. As potential cancer therapy agents, hydroalcoholic extracts of P. parviflora and A. cantula reveal cytotoxic potential. The distinctive cytotoxicity profiles among extracts and isolated compounds underscore the complexity of their mechanisms. Further exploration of the mechanisms and synergies with existing anticancer drugs is required to elucidate these findings, offering exciting prospects for the future..
Methanolic Extract of Neurocalynx calcinus for Promoting Wound Healing: Characterization by Ultra-High-Performance Liquid Chromatography High-Resolution Mass Spectrometry
Authors: A Anita , Diwekar Kalpana , KM Geetha
Published: April 2024

Wounds are physical injuries caused to living tissues due to discontinuation, disruption of cellular function, anatomical rupture, and functional issues in the concerned parts. Wound healing is an intricate restoration of damaged tissue by anabolic progression due to enhanced cellular function, matrix signaling, and various physiological processes. Still, a satisfactory solution is not viable for complete wound healing. Need of the hour is a wound healing product that is natural and easily available with a reduction in pain and finances, as well as restorations of tissue integration, with a minimum scar and quick healing. Based on ethno-pharmacological studies, Neurocalynx calcinus (Rubiaceae) was chosen for comprehensive research on in-vitro and in-vivo wound healing investigation. This plant is called “Pacha chedi” and is native to the jungles of Kerala and south India. The plant is reported to have antioxidant, analgesic, and anti-inflammatory properties, and it also showed significant wound healing, burn healing, and immune-enhancing properties. Several chemicals, such as flavonoids, were discovered in the NCME extract through ultra-performance liquid chromatography–high-resolution mass spectrometry analysis (UPHPLC-HRMS). Additionally, solutions with various NCME crude concentrations made with this extract were assessed for their anti-inflammatory, antibacterial, and acute dermal healing processes in a rat excision wound model and safety. The results of histopathology demonstrated the best rate of wound contraction. Compounds like glucoside, kaempferol, and quercetin ellagic acid were identified in NCME and are known as wound healers. The result also showed that NCME extract has good antimicrobial, anti-inflammatory, and antioxidant activity. It can probably be the next target for a novel drug from a phytochemical background, and it can play a significant role in accelerating wound healing by supporting traditional use.
Piper mullesua: Traditional Uses and Pharmacological Potential
Authors: Arvinder Kaur , VK Sohpal , Zabeer Ahmed
Published: April 2024

Piper mullesua, also referred to as “Mullesua,” is a member of the Piperaceae family of plants. This paper aims to offer a comprehensive insight into the pharmacological potential and traditional applications of P. mullesua. Due to the plant’s medicinal qualities, it has historically been used in numerous indigenous medical systems. Recent scientific investigations have also noted its potential medicinal uses, including its antioxidant, antibacterial, anti-inflammatory, and anticancer effects. This paper highlights the active ingredients, traditional applications, and pharmacological properties of P. mullesua while summarizing the currently available research. The study implies that additional research is necessary to fully investigate its therapeutic potential and to pinpoint the underlying mechanisms of action.
Virtual Reality Therapy Could be a Promising Alternative for Anxiety – A Review
Authors: Jodh Rahul V , Kawtikwar Pravin , Kawtikwar Ankita P , Khobragade Samiksha
Published: April 2024

Anxiety disorders are the major mental illnesses globally, characterized by a persistent and variable clinical course. These disorders probably have a severe impact on a person’s ability to function personally, socially, and professionally. A person suffering from such disorders could affect the standard of living. Anxiety disorders are classified within the vague category of neurotic illnesses. General disorders such as apprehension, fearfulness, restlessness, and agoraphobia are among the current categories of anxiety disorders. Anxiety is advantageous from an evolutionary standpoint since it promotes survival by motivating individuals to avoid hazardous environments. The frequency of symptoms associated with anxiety that are associated with each other is around 2 to 4% in the general population, and it may rise up to 20% with non-psychotic conditions. Then present systematic review aims to assess virtual reality therapy’s (VRT) effectiveness in treating anxiety disorders. Our aim is to highlight the existing research to ascertain the effectiveness of VRT in alleviating symptoms of anxiety as well as its possible advantages and constraints in comparison to conventional therapeutic approaches. The review will further explore the fundamental mechanics of VRT and pinpoint any lacuna in the existing literature that necessitates more attention. Furthermore, these reviews are significant because they provide insightful information about how VRT could be used to treat anxiety and evaluate the effectiveness of VRT as a therapeutic intervention.
Plants with Potential Neuropharmacological Activity: Plant-based Medicine for the Brain
Authors: Khare Nripen , Tare Harshal
Published: April 2024

This review article investigates the potential neuropharmacological activity of several plants in the context of plant-based medicine for brain health. The complex interplay of nature and neurology has aroused interest in exploiting plant-derived chemicals’ medicinal potential to promote cognitive enhancement, ease neurological illnesses, and safeguard brain health. This page gives an in-depth look at the neuropharmacologically active substances found in plants, ranging from alkaloids and flavonoids to terpenoids, and explains how they affect brain function. Traditional knowledge of plants used for neurological wellness is investigated, with a focus on cultural practices and historical applications. The review classifies plants based on their nootropic, anxiolytic, depressive, neuroprotective, analgesic, and sedative qualities, highlighting their potential to address various brain-related issues. Emerging research and future approaches highlight the changing environment of plant-based neuropharmacology, with a focus on safety and regulatory issues. The study highlights plant-based medicine’s prospective role in improving brain health and asks for more research and collaboration to uncover the full potential of nature’s neuropharmacological arsenal.
Énonciation textualisée, énonciation vocalisée
Authors: Violi Patrizia
Published: April 2024

Dans mon travail je voudrais considérer une forme assez particulière d’art du faire : l’art du dire. La sémiotique a toujours fort négligé cette forme de production du sens : sa tradition textualiste l’a portée à privilégier l’analyse des textes, en tant que productions déjà textualisées, plutôt que les pratiques qui produisent sens. Les outils de l’analyse sémiotique en effet ont été pensés pour les textes écrits ; en particulier la théorie de l’énonciation s’appuie sur le mouvement fondant et initial d’un acte de débrayage qui éloigne le produit textuel de son acte de production. Dans ce cadre-là, une sémiotique de l’oralité n’est pas arrivée à se définir d’une façon propre ; et en effet, elle a fait l’objet d’autres disciplines, comme l’analyse de la conversation ou la pragmatique linguistique. Les nouvelles directions de la recherche sémiotique actuelle, en se fonçant sur la processualité du sens et de l’énonciation, nous permettent d’approcher une sémiotique de l’oralité d’une façon différente. La sémiotique de l’oralité montrera alors de caractères peut-être pas trop loin des productions artistiques. Le rôle du corps producteur et de la matérialité du plan de l’expression, la processualité du sens, la place du sujet, une différente visée à l’intentionnalité constitueront autant de paliers pour cette enquête.
Le texte et ses pratiques d’instanciation
Authors: Dondero Maria Giulia
Published: April 2024

Ce travail vise à examiner certaines questions délicates qui touchent à la réflexion sémiotique aujourd’hui, comme la production du plan de l’expression, la textualisation et la constitution d’une sémiotique de l’expérience. Je prends ici en considération les notions de praxis énonciative et de syntaxe figurative afin de développer une réflexion sur l’instanciation du plan de l’expression des textes picturaux et photographiques
L’œuvre absente. Réflexion sur la pratique et sur ses objets
Authors: Bordron Jean-François
Published: April 2024

Nous cherchons à comprendre ce que veut dire praxis si, contrairement à la poesis ce terme désigne une action sans œuvre. Cette réflexion nous conduit, en deçà du récit, à l’origine des états de chose. Le support formel de l’état de chose est, dans le langage, la syntaxe de la scène prédicative. Mais qu’en est-il dans la praxis d’une part, dans la perception de l’autre ? Cette réflexion nous conduit à proposer la notion de « site » comme référentiel, et non comme support, susceptible de colocaliser un ensemble plus ou moins changeant de propriétés. Par ce biais, nous proposons une nouvelle définition de la notion d’objet, apte à nous faire comprendre comment ceux-ci émergent de la pratique.
Quel décor pour quel récit dans la bande dessinée contemporaine ?
Authors: Baetens Jan
Published: April 2024

Le présent article s’interroge sur la manière – plus ou moins ouverte ou contraignante – dont les particularités formelles et institutionnelles d’un média déterminent la nature aussi bien que la forme des représentations, en l’occurrence paysagères, de ce même média. Prenant l’exemple de la bande dessinée, on s’efforce dans un premier temps de poser quelques jalons d’une analyse de la ‘spécificité ‘ de ce média et d’examiner l’impact de cette spécificité sur les contenus suscités (ou permis) par ce média. Dans un second temps, on analyse une bande dessinée contemporaine, Vie et mort du héros triomphante de Frédéric Coché (2005), qui a la singularité de repenser un média (la tradition de l’eau forte et son iconographie traditionnelle) à l’intérieur d’un nouveau média (la bande dessinée muette, sans paroles). L’analyse du thème paysager révèle l’impact direct des médias mis en jeu sur le type de représentation sélectionné.
L’étude des paysages alluviaux par les techniques de l’écologie du paysage
Authors: Petit Stéphane
Published: April 2024

Parce que le paysage est depuis quelques années un sujet d’étude pour de nombreuses disciplines, sa définition peut varier en fonction de la perception de chaque spécialité. L’objectif de cette communication est, dans un premier temps, d’évoquer ce qu’est le paysage tel qu’il est défini par la discipline appelée “Ecologie du Paysage” : le paysage est considéré comme un espace hétérogène composé d’éléments qui interagissent dans l’espace ; il est caractérisé par sa dynamique et est gouverné en grande partie par les activités humaines. Son étude a comme perspective de comprendre comment, d’une part, il s’est formé et a évolué et, d’autre part, en quoi sa structure complexe influence son organisation et les processus écologiques.Dans un second temps, grâce à l’exemple des paysages alluviaux de la plaine d’inondation de la rivière Allier entre 1946 et 2000, nous aborderons la méthodologie d’étude de cet écocomplexe (Blandin et al. 1988). Fondée sur la cartographie et le calcul d’indices d’écologie du paysage et sur un large emploi des Systèmes d’Information Géographique (SIG), la démarche proposée permet notamment d’avoir une approche qualitative et quantitative du paysage, d’élaborer les étapes de sa mise en place ainsi que sa tendance évolutive.
Gem-difluorinative ring-expansion of alkenes
Authors: Wang Honggen , Li Yin , Liu Xiao-Bin , Sham Vadym , Logvinenko Ivan , Xue Jiang-Hao , Wu Jun-Yunzi , Fu Jia-Luo , Lin Shuang , Liu Yuan , Li Qingjiang , Mykhailiuk Pavel
Published: April 2024

Incorporating fluorine into aliphatic rings induces significant alterations in molecular conformation, acidity/basicity, and lipophilicity. Current methods for synthesizing fluorinated aliphatic rings, however, involve manipulating functional groups within pre-existing ring systems. Here, we have developed a novel chemical reaction - gem-difluorinative ring-expansion of methylenecycloalkanes. The reaction involves iodine(III) species, and allows the preparation of gem-difluorinated macrocyclic, fused, spiro, bridged, and natural product-derived structures. The protocol's practicality is demonstrated through several decagram-scale syntheses.
In-insect synthesis of oxygen-doped molecular nanocarbons
Authors: Usami Atsushi , Kono Hideya , Austen Vic , Phung Quan Manh , Shudo Hiroki , Kato Tomoki , Yamada Hayato , Yagi Akiko , Amaike Kazuma , Fujimoto Kazuhiro , Yanai Takeshi , Itami Kenichiro
Published: April 2024

Many functional molecules and materials have been produced using flask chemical reactions. Meanwhile, individual organisms, such as insects, have the potential to serve as natural, high-density cultivation equipment with multiple enzymes capable of complex reactions. However, research in this area has focused on the composition and reactivity of enzymes involved in biological reactions. Here, we report a unique "in-insect" unnatural product synthesis. Biotransformation using insect xenobiotic metabolism can selectively transform belt- and ring-shaped molecular nanocarbons into other difficult-to-prepare functional oxygen-doped derivatives. Cytochrome P450 variants are most likely the enzymes responsible for this reaction. Molecular dynamics simulations and quantum chemical calculations indicated a possible mode of substrate incorporation into the enzyme and an unconventional mechanism of direct oxygen insertion into carbon-carbon bonds.
Theory-guided synthesis of a 2D tungsten titanium MXene from a covalently bonded layered carbide for electrocatalysis
Authors: Thakur Anupma , Highland Wyatt , Wyatt Brian , Xu Jiayi , Chandran B. S. Nithin , Zhang Bowen , Hood Zachary , Adhikari Shiba , Oveisi Emad , Pacakova Barbara , Vega Fernando , Simon Jeffrey , Fruhling Colton , Reigle Benjamin , Asadi Mohammad , Shalaev Vladimir , Boltasseva Alexandra , Beechem Thomas , Liu Cong , Anasori Babak
Published: April 2024

Two-dimensional transition metal carbides, nitrides, and carbonitrides, known as MXenes, hold potential in electrocatalytic applications. Tungsten (W) based-MXenes are of particular interest as they are predicted to have low overpotentials in hydrogen evolution reaction (HER). However, incorporating W into the MXene structure has proven difficult due to the calculated instability of its hypothetical MAX precursors. In this study, we present a theory-guided synthesis of a W-containing MXene, W2TiC2Tx, derived from a non-MAX nanolaminated ternary carbide (W,Ti)4C4-y precursor by selective etching of one of the covalently bonded tungsten layers. Our results indicate the importance of W and Ti ordering and the presence of vacancy defects for the successful selective etching of the precursor. We confirm the atomistic out-of-plane ordering of W and Ti using density functional theory, Rietveld refinement, and electron microscopy methods. Additionally, the W-rich basal plane endows W2TiC2Tx MXene with a remarkable HER overpotential (~144 mV at 10 mA/cm2). This study adds a tungsten-containing MXene made from a covalently bonded non-MAX phase opening more ways to synthesize novel 2D materials.
Reparameterization of GFN1-xTB for Atmospheric Molecular Clusters: Applications to Multi-Acid–Multi-Base Systems
Authors: Knattrup Yosef , Kubečka Jakub , Wu Haide , Jensen Frank , Elm Jonas
Published: April 2024

Atmospheric molecular clusters, the onset of secondary aerosol formation, are a ma- jor part of the current uncertainty in modern climate models. Quantum chemical (QC) methods are usually employed in a funneling approach to identify the lowest free energy cluster structures. However, the funneling approach highly depends on the accuracy of low-cost methods to ensure that important low-lying minima are not missed. Here we present a reparameterized GFN1-xTB model based on the Clusteromics I–V datasets for studying atmospheric molecular (AMC) clusters, denoted AMC-xTB. The AMC- xTB model reduces the mean of electronic binding energy errors from 7–11.8 kcal/mol to roughly 0 kcal/mol and the root mean square deviation from 7.6–12.3 kcal/mol to 0.81–1.45 kcal/mol. In addition, the minimum structures obtained with AMC-xTB are closer to the ωB97X-D/6-31++G(d,p) level of theory compared to GFN1-xTB. We employ the new parameterization in two new configurational sampling workflows that include an additional meta-dynamics sampling step using CREST with the AMC-xTB model. The first workflow, denoted the “independent workflow”, is a commonly used funneling approach with an additional CREST step, and the second, the “improvement workflow”, where the best configuration currently known in the literature is improved with a CREST+AMC-xTB step. Testing the new workflow we find configurations lower in free energy for all the literature clusters with the largest improvement being up to 21 kcal/mol. Lastly, employing the improvement workflow we massively screened 288 multi-acid– multi-base clusters containing up to 8 different species. For these new multi-acid–multi- cluster systems we observe that the improvement workflow finds configurations lower in free energy for 245 out of 288 (85.1%) cluster structures. Most of the improvements are within 2 kcal/mol, but we see improvements up to 8.3 kcal/mol. Hence, we can recommend this new workflow based on the AMC-xTB model for future studies on atmospheric molecular clusters.
DIGITAL COMMERCE TRANSFORMATION: A STUDY ON THE IMPACT OF E-MONEY, E-WALLET, AND E-COMMERCE USE ON CONSUMER AND FINANCIAL BEHAVIOR
Authors: Gusti Girang Permata , da Hil
Published: April 2024

This research is a study of the impact of the use of e-money, e-wallet, and e-commerce on consumers and financial behavior in Indonesia. The research method used is descriptive quantitative using secondary data from sources such as Bank Indonesia and the Ministry of Communication and Information. The data includes e-money usage statistics, e-wallet usage surveys, and e-commerce transaction data from leading platforms. A descriptive analysis will be carried out to identify trends and patterns in the use of this digital payment technology by consumers and their impact on financial behavior. Data from Bank Indonesia shows a significant increase in the use of e-money, with the amount of e-money in circulation increasing by 34.28% from the end of 2021. A survey by the Ministry of Communication and Information (Kominfo-Indonesia) also noted that around 65.4% of respondents more often use e-wallets for non-cash transactions. The use of digital payment technology has brought changes in consumer behavior, who tend to be more active in shopping online. However, it should be remembered that the use of e-money, e-wallet, and e-commerce must also pay attention to security and consumer protection aspects. The study recommends a deeper analysis of transaction security and the protection of consumers’ data. In addition, it is recommended to continue research on the influence of digital payment technology on consumer financial management and consumer sentiment analysis on digital commerce transformation.
THE POTENTIAL USE OF QUICK RESPONSE (QR) CODES IN MOBILE BANKING: AN ANALYSIS OF IMPLEMENTATION AND ITS IMPACT ON USER EXPERIENCE
Authors: Gusti Girang Permata , da Hil
Published: April 2024

This study analyzes the potential for using Quick Response (QR) Codes in mobile banking services and their impact on user experience and the development of digital banking services. Focusing on the QR Code Indonesian Standard (QRIS) provided by Bank Indonesia, this research explains how QRIS enables efficient and safe non-cash transactions. Statistical data related to the growth of users and merchants adopting QRIS is used to illustrate the adoption of this technology. A quantitative descriptive approach was used to analyze secondary data that describes the growth of QRIS users and traders. In addition, decision-making theory is used to analyze the factors that influence the decisions of users and business people in adopting QR Codes. Research findings show that digital financial literacy, transaction security, and ease of use are important factors in influencing QRIS adoption. Based on the analysis, it is recommended that digital financial literacy, increasing transaction security, socializing the benefits of QRIS, and cross-sector collaboration be strengthened. In addition, there is a need for continuous evaluation and continuous innovation in digital banking services to optimize the adoption of QR Code technology.
ADOPTION OF ACCOUNTING INFORMATION SYSTEM SOFTWARE BY THE SMALL AND MEDIUM ENTERPRISES AT SANTA CRUZ, LAGUNA
Authors: Karla Pamela N Mangaba, , Beverly Ann T Alesna, , Georgelie G Franco, , Angela F Manalo, Manuela , Ann R Porcopio, Rose
Published: April 2024

This study was conducted with the aim of determining the factors that affect the adoption of accounting information system software. In this framework, an accounting information system is a system that a business uses for collecting, storing, managing, and reporting its financial data. To test the hypothesis that there is no significant difference in the factors affecting the adoption of accounting information system software as determined by the managers and its effects on the performance of the small and medium enterprises at Santa Cruz, Laguna, chi-square of independence was used. The data were collected using Google Forms. A total of eighty (80) respondents participated in the survey. The results show that only two factors, namely organizational and technological factors, have significantly affected the adoption of accounting information system software, and using AIS software can reduce the operational costs of small and medium enterprises. The findings suggest that management must be fully committed to adopting AIS to have effective decision-making, fasten the accounting or business transactions, and improve organizational performance.
RESEARCH ON THE OPTIMIZATION OF COLLEGE SECOND-HAND TRADING PLATFORM IN THE BACKGROUND OF GENERATION Z
Authors: Hong Binbin , Lu Shunyuan , Feng Linjie
Published: April 2024

In the Background of Generation Z and low-carbon lifestyle, the second-hand market in universities has attracted attention of public. Therefore, this paper analyzes the current situation of the second-hand market in universities and finds the market has great potential, and the trading goods have a trend of diversification and high-end. It is believed that the second-hand market in universities may become a blue ocean market. At the same time, the study clarifies the problems encountered in the development of second-hand trading in universities, such as lacking of professional campus trading platform, complex product categories, uneven quality and limited by time, place et al. To deal with the problems above mentioned, we point out some suggestions, like establishing a professional second-hand trading platform, classifying and labeling products and so on. It is also suggested that students in colleges should be actively guided to have a full understanding of second-hand goods in order to better promote the healthy development of second-hand economy in colleges. Furthermore, the optimization of the universities second-hand trading platform can also enhance the environmental awareness of Generation Z and help the country vigorously develop a low-carbon economy.
THE PREFERRED RETAIL FORMAT OF MILLENNIALS IN SOUTH AFRICA
Authors: Goldberg Roland , Gouws Johan
Published: April 2024

Within the dynamic realm of consumer behaviour, this study delves into the shopping preferences of South African Millennials, leveraging qualitative methods and an interpretive paradigm rooted in social theory. Through non-probability purposive sampling, insights from 21 participants aged 18 to 35, grouped into four focus groups, are analysed using Atlas.ti 23 and guided by Morse and Field’s stages. The findings unveil a nuanced interplay between online and offline shopping choices, shaped by product categories. Brick-and-mortar stores are preferred for fresh produce, high-value items, and clothing, while online platforms are favoured for budget-conscious purchases. Expansive shopping centers attract Millennials due to diverse offerings and immersive shopping experiences. Location and product range significantly impact the selection of physical stores, with local options preferred for convenience and comfort. Overall, this research underscores the enduring allure of brick-and-mortar stores among South African Millennials, especially within extensive shopping complexes tailored to their diverse preferences.
UTILIZING SOCIAL MEDIA IN DIGITAL MARKETING: TIPS AND TRICKS
Authors: da Hil , Gusti Girang Permata
Published: April 2024

Digital marketing that utilizes social media has become an effective strategy for increasing brand awareness and reaching a wider audience. In this research, we explore tips and tricks for utilizing social media in digital marketing with a focus on increasing brand awareness. A quantitative descriptive method was used using secondary data from the We Are Social report on social media and internet use in Indonesia in January 2023. These data provide insight into the behavior of social media and internet users, as well as reveal the potential and challenges in utilizing social media as a tool for effective marketing.
Romance Dramas Viewership and It's Impact on Audiences' Romantic Ideals
Authors: 曹 书乐 , 帕孜丽娅 阿力木
Published: April 2024

浪漫剧是当下最流行的国产电视剧类型之一,但少有学术研究系统地调查受众的浪漫叙事阅听经验与所持爱情理念的勾连。本文对过去十多年来最受欢迎的50部国产浪漫剧展开叙事分析和文本分析,又基于655份国产浪漫剧观众的有效问卷,分析了观众的观看行为特点,总结了观众通过观看浪漫剧所形成的浪漫理想、浪漫剧观看与其婚恋观的联系,以及性别的影响。研究发现,温和解语的英俊男性和自立自强的聪慧女性是最受喜爱的浪漫剧男女主角性别气质类型,体现出新语境下模糊二元对立边界的特质。真爱唯一、男女平等相待、爱需要时间的积累与考验、爱可以克服一切障碍,是最受喜爱的浪漫关系模式。浪漫剧观众中有30%的男观众,他们乐于与情感对象一起观看浪漫剧和讨论。约三分之二的浪漫剧观众具有积极正面的婚恋观,观看浪漫剧也在一定程度上让观众渴望爱情和亲密关系。
Inventing Pasts and Futures Speculative Design and Media Archaeology
Authors: 尤西 帕里卡
Published: April 2024

本文①
旨在于思辨设计的语境下思考媒介考古学和想象媒介项目意味着什么。这两个平行领域之间缺失的早期讨论专注于使用“想象过去”这一特殊角度来研究跨越媒介与设计的思辨实践的批判方法。思辨设计和想象媒介研究都感兴趣于如何创造替代世界及时间、社会和技术的表格以替代性的方式定位过去—未来的坐标。本文讨论了不同的艺术与设计项目,交叉运用了媒介和设计理论与实践的两种传统,旨在阐释媒介考古学如何为思辨设计与批判设计中的当代问题作出贡献。
Multifrequency microwave thermograph for biomedical applications
Authors: Stec Bronisław
Published: April 2024

This paper presents problems related to thermal radiation of human bodies in microwave range in aspect of diagnosis of breast carcinoma. A mathematical model of thermal radiation transfer through tissues is introduced and methods of measurement of temperature, depth and size of a heat source, by means of multifrequency microwave thermography are described. Theoretical considerations are supplemented by presentation of experimental results.
New approach to power semiconductor devices modeling
Authors: Napieralski Andrzej , Napieralska Małgorzata
Published: April 2024

The main problems occurring during high power device modeling are discussed in this paper. Unipolar and bipolar device properties are compared and the problems concerning high time-constant values related to the diffusion phenomena in the large base are explained. Traditional and novel concepts of power device simulation are presented. In order to make accurate and modern semiconductor device models widely accessible, a website has been designed and made available to Internet users http://www.dmcs.p.lodz.pl/dmcs-spice, allowing them to perform simulations of electronic circuits containing high power semiconductor devices. In this software, a new distributed model of power diode has been included. Together with the existing VDMOS macromodel library, the presented approach can facilitate the design process of power circuits. In the future, distributed models of IGBT, BJT and thyristor will be added.
Critical modeling issues of SiGe semiconductor devices
Authors: Palankovski Vassil , Selberherr Siegfried
Published: April 2024

We present the state-of-the-art in simulation of silicon-germanium (SiGe) semiconductor devices. The work includes a detailed comparison of device simulators and current transport models. Among the critical modeling issues addressed in the paper, special attention is focused on the description of the anisotropic majority/minority electron mobility in strained SiGe grown on Si. We use a direct approach to obtain scattering parameters S-parameters and other derived figures of merit of SiGe heterojunction bipolar transistors (HBTs) by means of small-signal AC-analysis. Results from two-dimensional hydrodynamic simulations of SiGe HBTs are presented in good agreement with measured data. The examples are chosen to demonstrate technologically important issues which can be addressed and solved by device simulation.
An exact algorithm for design of content delivery networks in MPLS environment
Authors: Walkowiak Krzysztof
Published: April 2024

Content delivery network (CDN) is an efficient and inexpensive method to improve Internet service quality. In this paper we formulate an optimisation problem of replica location in a CDN using MPLS techniques. A novelty, comparing to previous work on this subject, is modelling the network flow as connection-oriented and introduction of capacity constraint on network links to the problem. Since the considered optimisation problem is NP-complete, we propose and discuss exact algorithm based on the branch-and-cut and branch-and-bound methods. We present results of numerical experiments showing comparison of branch-and-cut and branch-and-bound methods.
Fairness considerations with algorithms for elastic traffic routing
Authors: Cinkler Tibor , Laborczi Péter , Pióro Michał
Published: April 2024

The bit rate of modern applications typically varies in time. We consider the traffic elastic if the rate of the sources can be controlled as a function of free resources along the route of that traffic. The objective is to route the demands optimally in sense of increasing the total network throughput while setting the rates of sources in a fair way. We propose a new fairness definition the relative fairness that handles lower and upper bounds on the traffic rate of each source and we compare it with two other known fairness definitions, namely, the max-min and the proportional rate fairness. We propose and compare different routing algorithms, all with three types of fairness definitions. The algorithms are all a tradeoff between network throughput, fairness and computational time.
Preface
Authors: Woźniak Józef
Published: April 2024

Preface
Exploring agent-based wireless business models and decision support applications in an airport environment
Authors: Wang Yapeng , Cuthbert Laurie , Mullany Francis J. , Stathopoulos Panagiotis , Tountopoulos Vasilios , Sotiriou Dimitrios Athanasios , Mitrou Nikolas , Senis Michael
Published: April 2024

This paper describes an intelligent communication and decision support system for providing wireless services in an airport environment. A novel agent-based business model is proposed and the value chain is analysed for wireless applications. This system is studied and developed within the scope of the IST ADAMANT project, where the Athens International Airport (AIA) is used as the trial environment. First of all, a set of advanced, realistic decision support application scenarios enhancing the airport facilities both for the passengers and for the airport staff is identified. Most of the applications can be summarised as location-based personalised services. They refer both to airport internal users and to passenger users. In order to provide these services, location-sensitive service level agreements (SLAs) and radio resource management (RRM) are introduced. The design of such a system is envisaged based on a generic, multi-agent architecture, which is also presented in this paper.
A new methodology of accounting for uncertainty factors in multiple criteria decision making problems
Authors: Kalika Vladimir I.
Published: April 2024

A new approach is proposed to select a predetermined number of ``reasonable`` (the best in a certain sense) alternatives from the considerable (maybe a vast) set of initial alternatives according to an arbitrary number of optimization criteria and accounting for uncertainty factors. The approach is based on using a special intuitive methodology, developed to account for uncertainty factors when solving such multiple criteria decision making (MCDM) problems. This methodology is based on performing multi-variant computations (MVC) and finding their ``stable-optimal`` solutions, and it`s realized as a multi-level hierarchical system of MVC series. It`s possible to use this methodology for solving various real problems.