bluuebunny/crossref_metadata_2025 huggingface dataset:
Materiales de bajo costo para la construcción de viviendas económicas
Authors: Ochoa María Teresa , Toirac Corral José
Published: May 2019

La vivienda, necesidad sentida de la población, representa el espacio físico donde se establece la familia, núcleo básico de toda organización social En la actualidad más de la cuarta parte de la población mundial (más de mil millones de personas) carecen literalmente de un hogar o viven en condiciones miserables, problema al cual escapan las naciones desarrolladas En nuestro país, reducir el déficit de viviendas y mejorar las condiciones del hábitat constituye un reto a enfrentar no sólo por dirigentes del gobierno encargados de esta política, sino también por todos los profesionales y empresarios de la construcción, los cuales deben preocuparse en buscar soluciones que permitan disminuir los costos de la vivienda tradicional haciéndola accesible no sólo a personas de altos y medianos ingresos sino también a las clases más pobres y necesitadas Aplicando nuestro conocimiento y experiencia sobre el tema, el presente trabajo recoge resultados concretos sobre la producción y uso de nuevos materiales de construcción alternativos a partir de materias primas nacionales. Estos, al sustituir los tradicionales producen un significativo ahorro en los costos, pudiendo, luego de su desarrollo a nivel industrial ser aplicado masivamente a diversos proyectos habitacionales, urbanos, sub-urbanos y rurales, además de hacerlos más asequibles a un gran número de personas de bajos ingresos que con su esfuerzo y medios propios pudieran alcanzar su anhelado techo.
A PERSPECTIVE ON AUSTRALIA’S NATIONAL MEDICINES POLICY
Authors: Tett Susan E
Published: May 2019

There is international interest in Australia’s health care system for prescription medicines. The issue is particularly topical in Canada with the debate following publication of the Romanow Report into the future of health care in Canada. This Report recommended a new National Drug Agency. Australia has a National Medicines Policy with four arms – quality, safety and efficacy of medicines; equity of access; a viable and responsible pharmaceutical industry; quality use of medicines.  The  four  arms  of  the  Policy  are  interlinked  and  interdependent  for  optimal functioning. In this paper, an overview of how the prescription drug system in Australia works is presented.  The  manuscript  focuses  upon  specific  aspects  of  the  Policy,  describing  how  it functions and some of the processes integral to success, from the viewpoint of the author. The discussion includes some of the advantages of Australia’s system for pharmaceuticals as well as some of the problems, as these present opportunities for development and change
The Information Provision in the Corporate Acquisition Process: Why Target Firms Obtain Multiple Fairness Opinions
Authors: Liu Tingting
Published: May 2019

Using a hand-collected dataset for takeovers from 1996 to 2013, I examine why some target firms obtain a second fairness opinion and the associated wealth effects of doing so. I find that multiple opinions are more likely to be used in deals in which management/investment bank conflicts of interest are high—e.g., buyouts and stapled financing deals. In addition, the use of a second opinion has a significantly positive impact on target shareholders' wealth in these two types of deals. Fairness opinion valuation predominantly relies on accounting data, and the benefit of seeking a second opinion increases with a firm's earnings quality. Collectively, the results suggest that a second opinion is used to facilitate transactions.

JEL Classifications: G34; G24; J33.
Firm Risk and Disclosures about Dispersion of Asset Values: Evidence from Oil and Gas Reserves
Authors: Badia Marc , Barth Mary E. , Duro Miguel , Ormazabal Gaizka
Published: May 2019

The question we address is whether mandated disclosure about dispersion of nonfinancial asset values can provide information relevant to assessing firm risk. Using a sample of Canadian oil and gas (O&G) firms between 2004 and 2011, we find that the difference between the disclosed 10th and 50th percentiles from the O&G reserves distribution, which measures dispersion of the distribution, is positively associated with future total and idiosyncratic equity return volatility, systematic risk, and credit risk. We also find that disclosure of increased reserves dispersion is associated with weaker stock price reactions to increases in reserves and with increases in bid-ask spreads, both of which indicate the disclosures convey information about risk associated with reserves. Additional tests reveal little evidence of managerial opportunism in the reserves disclosures. Taken together, our evidence suggests that quantitative disclosures about the dispersion of nonfinancial asset values can provide information relevant to assessing firm risk.
Tone Concavity around Expected Earnings
Authors: D'Augusta Carlo , DeAngelis Matthew D.
Published: May 2019

We examine whether the relationship between managerial tone and earnings performance depends on the performance of the firm relative to earnings expectations. Using both annual changes in earnings and the difference between realized earnings and analyst consensus forecasts, we find evidence of “tone concavity” around earnings expectations. Specifically, the covariance between managerial tone and earnings performance is positive when earnings are below expectations, but negative when earnings meet or exceed expectations. We interpret our results to suggest that managers downplay positive changes in earnings to attenuate future growth expectations. We also find that tone concavity is significantly attenuated by managers' career concerns and accounting conservatism, but unrelated to litigation risk. Our results indicate that the effect of earnings performance on disclosure tone is complex and reflects managers' incentives to manage expectations.
Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice
Authors: Nguyen Chuong Minh , Tartar Danielle Marie , Bagood Michelle Dawn , So Michelle , Nguyen Alan Vu , Gallegos Anthony , Fregoso Daniel , Serrano Jorge , Nguyen Duc , Degovics Doniz , Adams Andrew , Harouni Benjamin , Fuentes Jaime Joel , Gareau Melanie G. , Crawford Robert William , Soulika Athena M. , Isseroff Roslyn Rivkah
Published: May 2019

Diabetic foot ulcers represent a significant source of morbidity in the U.S., with rapidly escalating costs to the health care system. Multiple pathophysiological disturbances converge to result in delayed epithelialization and persistent inflammation. Serotonin (5-hydroxytryptamine [5-HT]) and the selective serotonin reuptake inhibitor fluoxetine (FLX) have both been shown to have immunomodulatory effects. Here we extend their utility as a therapeutic alternative for nonhealing diabetic wounds by demonstrating their ability to interact with multiple pathways involved in wound healing. We show that topically applied FLX improves cutaneous wound healing in vivo. Mechanistically, we demonstrate that FLX not only increases keratinocyte migration but also shifts the local immune milieu toward a less inflammatory phenotype in vivo without altering behavior. By targeting the serotonin pathway in wound healing, we demonstrate the potential of repurposing FLX as a safe topical for the challenging clinical problem of diabetic wounds.
¿Qué frena la democracia en Hong Kong? Entre elites económicas y sombrillas amarillas
Authors: Gélvez Rubio Tatiana
Published: May 2019

Hong Kong presenta un caso que pone en cuestión la teoría de modernización de Samuel Huntington. Por una parte, se señala como impedimento el retorno de la soberanía a la República Popular China. Sin embargo, incluso durante el control británico, no desarrolló instituciones democráticas. El presente artículo plantea las implicaciones de la presencia de élites económicas en la política de Hong Kong. Se concluye que, además de la clara intervención china en el consejo legislativo, las protestas de las sombrillas amarillas indican que una parte de la ciudadanía muestra inconformidad con la situación política, buscando alternativas de participación política.
La auténtica alternativa al naturalismo de la conciencia
Authors: Ferrer Santos Urbano
Published: May 2019

La naturalización creciente de los saberes ha dejado la conciencia pendiente de explicación. Pero en mi opinión su restablecimiento no reduccionista no puede correr a cargo del dualismo cartesiano ni de la mera aplicación al hombre de la noción de sistema. Se examinan seguidamente el papel de la teleología como causa interna al viviente, el saber hablar y la intencionalidad propia de los actos de conciencia y de los actos voluntarios, como procedimientos para dejar a salvo la unidad del viviente humano sin tener que acoplarle desde fuera la corporeidad. Palabras-clave: sistema, teleología, causalidad, monismo, dualidad.
La conciencia, no solo inexplicada, también inexplicable. ¿Por qué?
Authors: Vilaplana Guerrero José Domingo
Published: May 2019

La inexplicabilidad de la conciencia constituye una de las tesis más audaces y radicales de la actual filosofía de la mente por cuanto desafía la aspiración naturalista a desentrañar reductivamente cualquier forma de realidad y, por extensión, la realidad específicamente humana. Esta ponencia se centra en destacar, esclarecer y discutir, siquiera sumariamente, algunos de los argumentos que Juan Arana, en La conciencia inexplicada, esgrime para sustentar su tesis de la inexplicabilidad de la conciencia.
Creencia y química
Authors: Gómez Pérez Rafael
Published: May 2019

Que exista solo la materia es una creencia, no demostrada experimentalmente. Y cuando se pretende que un estudio exhaustivo del cerebro humano da cuenta de la inexistencia del alma se incurre en varias falacias. Por otro lado hay muchas otras formas de conocimiento, además del experimental. Por ejemplo, el acercamiento a la realidad a través del sentido de la belleza.
La sensibilidad de la verdad
Authors: Labrada María Antonia
Published: May 2019

En este artículo se analiza la dialéctica entre sensibilidad y concepto presente en el libro de Inciarte Cultura y verdad. Esta dialéctica se añade a la existente entre objetividad y subjetividad, y el que y el cómo, en el análisis que hace el autor de la relación entre cultura y fe.
La inmediatez de la muerte y su significado racional
Authors: Martí Sánchez Miguel
Published: May 2019

El presente artículo aclara la tesis de Fernando Inciarte según la cual la muerte en cuanto tal coloca al ser humano ante lo inmediato, es decir, más allá del horizonte que le abre su comprensión mundana. Esta inmediatez, dice Inciarte, es un indicio de que es razonable esperar algo más que la muerte, y por lo tanto que la razón no comete ningún crimen si se abre a la fe. Para contrastar esta idea se acude a la ayuda de la tradición filosófica, sobre todo, aunque no solo, a la fenomenología. A partir de la sucinta exposición de diferentes posturas sobre el morir y la muerte se elabora un discurso unitario sobre su significado para el ser humano. Se demuestra que la postura de Inciarte, lejos de conducir a un fideísmo, se basa más bien en argumentos racionales de validez contrastada.
In vitro and in vivo activities of flavonoids – apigenin, baicalin, chrysin, scutellarin – in regulation of hypertension – a review for their possible effects in pregnancy-induced hypertension
Authors: Ożarowski Marcin , Kujawski Radosław , Mikołajczak Przemysław Ł. , Wielgus Karolina , Klejewski Andrzej , Wolski Hubert , Seremak-Mrozikiewicz Agnieszka
Published: May 2019

Flavonoids and their conjugates are the most important group of natural chemical compounds in drug discovery and development. The search for pharmacological activity and new mechanisms of activity of these chemical compounds, which may inhibit mediators of inflammation and influence the structure and function of endothelial cells, can be an interesting pharmacological strategy for the prevention and adjunctive treatments of hypertension, especially induced by pregnancy. Because cardiovascular diseases have multi-factorial pathogenesis these natural chemical compounds with wide spectrum of biological activities are the most interesting source of new drugs. Extracts from one of the most popular plant used in Traditional Chinese Medicine, Scutellaria baicalensis Georgi could be a very interesting source of flavonoids because of its exact content in quercetin, apigenin, chrysin and scutellarin as well as in baicalin. These flavonoids exert vasoprotective properties and many activities such as: anti-oxidative via several pathways, anti-in-flammatory, anti-ischaemic, cardioprotective and anti-hypertensive. However, there is lack of summaries of results of studies in context of potential and future application of flavonoids with determined composition and activity. Our review aims to provide a literature survey of in vitro, in vivo and ex vivo pharmacological studies of selected flavonoids (apigenin, chrysin and scutellarin, baicalin) in various models of hypertension carried out in 2008–2018.
Litogenolitic and solubility properties of products obtained from common ivy extract (Hederae helicis e folium) and medium of diversified polarity (εM)
Authors: Nowak Elżbieta , Marczyński Zbigniew , Skibska Beata , Nachajski Michał Jakub , Jambor Jerzy , Zgoda Marian Mikołaj
Published: May 2019

Introduction: Common ivy (Hedera helix) is a plant used successfully in the treatment of various ailments. This is possible owing to the unique set of substances contained in it such as large amount of saponins, flavonoids, phenolic acids and phytosterols as well as polyacetylenes and coumarins. All these substances have been used in the production of cosmetic and medicinal preparations. Clinical trials on the efficacy and safety of dry ivy leaf extract have shown its high efficacy, comparable to synthetic medications, and better tolerance of herbal drugs.

Objective: Investigations were performed on model ivy leaf (Hedera helix) extracts which were created using a medium of diversified polarity ( εM). Measurements of viscosity and surface activity on phase boundary were performed. During preformulation studies attention was drawn to the possibility of micellar solubilization of cholesterol and selected structures of nonsteroidal anti-inflammatory drugs (NSAIDs) – ketoprofen.

Methods: Viscosity measurements of Extractum Hederae helicis e folium aqueous solutions and in 0.1 mol HCl were performed according to the Polish Standard with Ubbelohde dilution viscometer. The surface tension of aqueous solutions

-
Δ

γ

sol

25

$- \Delta \gamma _{{\rm{sol}}}^{25}$

of Hederae helicis e folium extracts was determined according to the Polish Standard with stalagmometric method. Critical micellar concentration (cmc) was calculated. This enabled to evaluate the dependence

Δ

G

m
0

=
2.303
 

$\Delta {\rm{G}}_{\rm{m}}^0 = 2.303$

RT×log cmc of the thermodynamic potential of micelle formation (

Δ

G

m
0

$\Delta {\rm{G}}_{\rm{m}}^0$

). Results: It has been confirmed in the conducted comparative studies that aqueous solutions of Extr. Hederae helicis e folium created with maltodextrin as well as with SiO2 – maltodextrin result in micellar solubilization. The increase of granulometric size of cholesterol particle to Ø 1.60 mm decreased the amount of solubilized cholesterol but solubility preferences of the extracts were maintained.

Conclusions: Model extracts produced from Hederae helicis e folium with diversified polarity of the extraction medium (water – ethanol) are characterized by appropriate solubility of the components which results not only from the presence of chlorophyll and its derivatives in the extract but also from the technique used for spray drying of the extract.
Impact of Curcuma longa extract on the expression level of brain transporters in in vivo model
Authors: Bukowska Marta , Bogacz Anna , Wolek Marlena , Mikołajczak Przemysław Ł. , Olbromski Piotr , Kamiński Adam , Czerny Bogusław
Published: May 2019

Introduction: Blood brain barrier and multidrug resistance phenomenon are subjects of many investigations. Mainly, because of their functions in protecting the central nervous system (CNS) by blocking the delivery of toxic substances to the brain. This special function has some disadvantages, like drug delivery to the brain in neurodegenerative diseases

Objective: The aim of this study was to examine how natural and synthetic substances affect the expression levels of genes (Mdr1a, Mdr1b, Mrp1, Mrp2, Oatp1a4, Oatp1a5 and Oatp1c1) that encode transporters in the blood-brain barrier.

Methods: cDNA was synthesized from total RNA isolated from rat hippocampus. The expression level of genes was determined using real-time PCR (RT-PCR) method.

Results: Our findings showed that verapamil, as a synthetic substance, caused the greatest reduction of mRNA level of genes studied. The standardized extract of Curcuma longa reduced the expression level for Mrp1 and Mrp2, whereas the increase of mRNA level was observed for Mdr1b, Oatp1a5 and Oatp1c1.

Conclusions: These results suggests that herbal extracts may play an important role in overcoming the blood brain barrier during pharmacotherapy.
Ethnobotanical study of traditional herbal plants used by local people of Seshachalam Biosphere Reserve in Eastern Ghats, India
Authors: Reddy Araveeti Madhusudhana , Babu Madha Venkata Suresh , Rao Ramachandra Raghavendra
Published: May 2019

Introduction: Ethnobotany is the study of medicinal plants used by local people, with particular importance of old-styled tribal beliefs and information. Ethnobotanical studies focus on ethnic knowledge of Adivasi people and development of data bases on ethnic knowledge but also focuses on preservation and regeneration of traditional beliefs and maintenance of traditional knowledge.

Objective: The aim of present study is to highlight the traditional actions of herbal plants used by inborn Yanadi community of Seshachalam Biosphere Reserve, Eastern Ghats of Andhra Pradesh, India.

Methods: The ethnobotanical field survey was conducted according to the methods adopted by some authors. In-depth interviews, interactions were conducted with tribal physicians of Yanadi, Nakkala and Irula as well as other tribes practicing and experiencing the use of plant-based medicine. A normal inquiry form was used to gather the appropriate data on herbal plants and their usage of inborn people’s lifestyle. Extensive consultations among local people and detailed documentation of the usage of plants were carried out

Results: A total of 266 medicinally used plant species belonging to 216 genera and 88 families were recognized with help of inborn herbal healers. The study also chronicled the mode of herbal arrangements, mode of the use of herbal plants in various disorders. The study exposed that native people of Seshachalam Biosphere Reserve have good medicinal information and also have preserved plant-based medicinal system of their ascendants used all their diseases. Most of medicinal plants are used in the treatment of indigestion, snake bite and skin diseases. The authors feel that this type of study certainly helps identify ethnic leads for drug development in future.

Conclusions: The ethnobotanical investigation of Seshalam Biosphere area has revealed that the tribes possess good knowledge on plant-based medicine but as they are towards in advanced exposure to transformation, their information on traditional uses of plants is slowly getting eroded. The authors plead for intensive crosscultural studies involving all ethnic tribes in the country for prioritizing or short listing of ethnic leads for various disorders for ultimately developing global level drugs for human welfare and economy development.
Pedagogos da SRE-OP: Desvelando o perfil, as escolhas e a formação desses profissionais
Authors: Lucindo Nilzilene Imaculada , Araújo Regina Magna Bonifácio de
Published: May 2019

Este artigo resulta de uma pesquisa de Mestrado que buscou conhecer quem são os pedagogos que atuam nas instituições de ensino público da Superintendência Regional de Ensino de Ouro Preto. O estudo, de abordagem qualitativa, privilegiou a pesquisa documental, bibliográfica e de campo. Os dados foram coletados por questionário e entrevista e tratados pela análise de conteúdo. Identificamos que a escolha pela Pedagogia teve influência do curso de Magistério e que esses pedagogos são os especialistas de educação que se formaram na vigência do Parecer CFE nº 252/69, quando o curso estava estruturado por habilitações. A formação inicial teve cunho mais teórico que prático, com pouco incentivo à pesquisa e, quanto à formação continuada, os pedagogos hoje se formam participando de cursos, congressos, pesquisando, trocando experiências com outros profissionais e participam, também, das formações ofertadas aos docentes, pois não há uma formação específica para esses sujeitos.
The Optimal Control of Two Work-Stealing Deques, Moving One After Another in a Shared Memory
Authors: Барковский Евгений Александрович , Лазутина Анна Александровна , Соколов Андрей Владимирович
Published: May 2019

В work-stealing балансировщиках параллельных задач, каждое ядро имеет свой буфер задач—дек (англ. deque). Владелец дека использует один конец для добавления и извлечения задач, а из второго конца задачи перехватываются другими ядрами. В статье анализируются два метода представления деков: один из распространенных методов—раздельное последовательное циклическое представление деков; и новый предложенный нами метод, где общая память для деков заранее не делится и они двигаются друг за другом по кругу. Ранее эти методы анализировались нами для представления FIFO-очередей в сетевых приложениях, где для некоторых значений параметров системы метод «Друг за другом» давал лучший результат.

Целью исследования является построение и анализ модели процесса работы с двумя последовательными деками, когда они двигаются друг за другом по кругу в общей памяти. Математическую модель мы будем строить как случайное блуждание по целым точкам в пирамиде. Имитационная модель строится с помощью метода Монте-Карло. Используемая стратегия work-stealing—перехват одного элемента. Предложены математическая и имитационная модели данного процесса и проведены численные эксперименты.
Passion to Heal – Dermatology volunteering in the Maasai Mara, Kenya
Authors: Dhandha Maulik M
Published: May 2019

During summer of 2018, ME to WE organized a dermatology volunteer trip in Masai Mara region of Kenya. Our volunteer group included physicians, physician assistants and medical assistants. We volunteered at the Baraka Hospital along with the local staff there. Our goal was to help treat and triage patients with skin conditions and in the process educate local staff about Dermatology. We saw patients with a variety of skin conditions, including Filariasis, Onchocerciasis, Chromoblastomycosis, Discoid Lupus and others. In addition, we visited local schools to screen students with common skin conditions. We saw approximately 800-100 patients during our time there. On our last day at the hospital we organized lectures to teach the local team about common skin conditions. The key challenges to our work there were limited resources and time available, socio-economic difficulties of the local population, lack of an established dermato-pathology center, etc. The key strengths of the trip were very well organized trip from ticketing to lodging to itinerary, very supportive local staff and how grateful patients were with evaluation of their conditions. Our trip also included local cultural programs that allowed us to learn more about the people there. In a short span of one week, we were able to help in the care of the local patient population and in the process learn about local culture, socio-economic structure and medical practice there.
Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities Towards EGFR Mutants
Authors: Toenjes Sean T. , Garcia Valeria , Maddox Sean M. , Dawson Greg A. , Ortiz Maria A. , Piedrafita F. Javier , Gustafson Jeffrey
Published: May 2019

Unstable atropisomerism is innate in many common scaffolds in drug discovery, commonly existing as freely rotating aryl-aryl bonds. Such compounds can access the majority of dihedral conformations around the bond axis, however most small-molecules bind their target within a narrow range of these available conformations. The remaining accessible conformations can interact with other proteins leading to compound promiscuity. Herein, we leverage atropisomerism to restrict the accessible low energy dihedral conformations available to a promiscuous kinase inhibitor and achieve highly selective and potent inhibitors of the oncogenic target RET kinase. We then evaluate our lead inhibitor against kinases that were predicted to bind compounds in a similar conformational window to RET, discovering a potent inhibitor of drug resistant EGFR mutants including L858R/T790M/C797S EGFR. Leveraging atropisomerism to restrict accessible conformational space should be a generally applicable strategy due to the prevalence of unstable atropisomerism in drug discovery.
Palladium/ Zeolite Low Temperature Passive NOx Adsorbers (PNA): Structure-Adsorption Property Relationships for Hydrothermally Aged PNA Materials
Authors: Khivantsev Konstantin , Jaegers Nicholas R. , Kovarik Libor , Hu Jian Zhi , Wang Yong , Gao Feng , Szanyi János
Published: May 2019

Zeolites with different framework structures (SSZ-13, ZSM-5, BEA) but similar Si/Al ratios and Pd loading (~1 wt%) were synthesized and evaluated as low temperature passive NOx adsorbers (PNA). These materials exhibit high NOx adsorption efficiency with atomically dispersed Pd the active adsorption site. Hydrothermal aging at 750 ºC for 16 hours in the presence of 10% water vapor in air resulted in the formation of PdO nanoparticles in all three samples as evidenced by high energy XRD. Hydrothermal aging of the small-pore Pd/SSZ-13 (Si/Al = 6), which contain ~100-90% atomically dispersed palladium ions, decreases its PNA performance only by ~10-20%, indicating agglomeration of only ~10-20% of all atomically dispersed Pd into PdO. High-field solid state 27Al NMR studies on the fresh and aged samples substantiate dealumination and significant changes in the distribution of Al (and thus, Brönsted acid) sites after hydrothermal aging. FTIR measurements with NO probe molecule and titration of Brönsted acid sites with nitrosyl (NO+) ions further corroborate the 27Al NMR data. Because framework aluminum atoms are the anchoring sites for atomically dispersed Pd ions, their elution from the framework causes the loss of active atomically dispersed Pd species. With the aid of HAADF-STEM imaging and synchrotron XRD studies, we further confirm and visualize the fate of these Pd species – they agglomerate into PdO nanoparticles on the external surface of zeolite. Consequently, these changes lead to the decrease in PNA performance of these materials after hydrothermal aging. The thus formed agglomerates cannot be re-dispersed back to their ionic state due to the loss of framework Al T-sites and/or inherent stability of such large PdO particles. Our study demonstrates that, unlike in previous studies that found increased PNA performance upon HTA, high temperatures hydrothermal aging of PNA materials, that contain atomically dispersed Pd initially, results in a decrease in NOx storage efficiency due to the formation of PdO agglomerates. However, we also highlight the high hydrothermal stability of predominantly atomically dispersed 1-3 wt% Pd/SSZ-13 (Si/Al = 6), whose performance decreases only marginally after prolonged hydrothermal aging at 750 ºC. This study shows that hydrothermally stable passive NOx materials can be prepared using small-pore SSZ-13 zeolite.
Pengendalian Persediaan Produk Obat Herbal pada Permintaan Probabilistik Menggunakan Joint Economic Lot Size
Authors: Heryanto Rainisa Maini , Setiawan Yosi Thedi , Arisandhy Vivi
Published: May 2019

Integration in supply chain is an important factor to consider. Good integration between entity in supply chain can give some advantages from minimize cost to competitiveness between supply chain.  Company X is manufacturer of herbs medicine which has single distributor to sell the product. Currently, manufacturer and distributor have their inventory control policies and there is no coordination among echelon. It causes the difference number of production lot from manufacturer and the number of order from distributor, consequently total inventory cost become expensive.This research will propose Joint Economic Lot Size (JELS) method that can integrate these two echelons and will give the minimum total inventory cost. The proposed JELS method is integration between Cardenas-Barron model about EPQ backorder and Ben-Daya and Hariga model about integration model between single supplier and single consumer. Calculation process begin with forecasting demand, calculation of actual inventory control at echelon manufacturer and distributor, and calculation of proposed method. The result of calculation process show that total actual inventory cost is 5.500.371,476 IDR/month and the proposed method give 4.604.766,665 IDR/month. The proposed method can give saving about 895.604,811 IDR/month or 16,28%.                      Key words: cost, integration, JELS, inventory
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA MATAKULIAH STATISTIKA PENDIDIKAN
Authors: Purnomo Eko Andy , Dalyono Bambang , Handayani Sri
Published: May 2019

The curriculum and technology development hand in hand very rapidly, so it takes a concept and mechanism of ICT-based teaching and learning. The transformation process of conventional education into digital form, both in its content and its system. The progress of this technology should be utilized by the students as a provision in the classroom learning. Students are required to innovate and apply ICT in learning. Based on these things required a design and supplement learning materials so students can carry out in accordance with the demands. The one of innovation form is android-based learning media on n statistical education subject. The stages of this android system using pretest, practice working on the matter, as well as a posttest. In addition, the whole tutorial material such as SAT, RAT, concept maps and materials could be obtained by students through media-based android. The purpose of this research is to 1). know the process of developing android-based learning media is valid, 2). know the response of the students towards the implementation of the android-based learning media. The subject of this research was students of UT-UPBJJ Semarang pokjar Kendal. The development of the design and supplement learning materials used the 4-D model of Thiagarajan, Semmel Semmel and IE (define, design, develop, and disseminate). The method of data collection used interviews, observation, and question form. Based on the stages of the learning media development can be concluded 1). the android-based learning media development on educational statistics subject. The validity got 4.22 and included within the category of very valid. 2).The students ‘responses on the media-based learning android on education statistics subject had good responses. The students’ responses categories were very good 3.40.
PENGARUH PENDEKATAN PROBLEM POSING DAN CTL TERHADAP KEMAMPUAN BERPIKIR KRITIS DALAM PEMBELAJARAN MATEMATIKA BAGI SISWA SMA
Authors: Shanti Widha Nur , Sholihah Dyahsih Alin , Abdullah Ahmad Anis
Published: May 2019

This study aims to determine the effect of the Problem Posing approach and the Contextual Teaching and Learning (CTL) approach to critical thinking skills. This study is a quasi-experimental study with randomize design pretest-posttest control group design. The population of this study were all class X students of SMA Negeri 1 Sentolo consisting of six classes. From the population, two classes were randomly sampled as the research sample, namely class X MIA 3 and class X MIA 1. In class X MIA 3 students applied learning using the Problem Posing approach and class X MIA 1 students used the CTL approach. The instrument used to collect data is a test of critical thinking skills. To examine the effect of the Problem Posing approach and the CTL approach on critical thinking ability data were analyzed using the t test. The results showed that there were differences in the ability to think critically between classes with learning using the Problem Posing approach and the classroom with learning using the CTL approach, with the average students 'critical thinking skills in the class with the Problem Posing approach higher than the students' critical thinking skills. in the class with the CTL approach.
Biología e inmunopatogénesis del carcinoma espinocelular y el basocelular
Authors: Mejía Ana María , Velásquez Margarita María
Published: May 2019

El cáncer de piel es el tipo de cáncer más frecuente. El cáncer de piel no melanoma incluye el carcinoma basocelular y el carcinoma espinocelular. Debido a que la mayoría son poco agresivos y a que algunos se resecan sin estudio histopatológico, existe un subregistro. Esta revisión se enfoca en los aspectos más importantes de la biología y la inmunopatogénesis del carcinoma basocelular y del espinocelular.Los factores de riesgo incluyen la exposición a los rayos ultravioleta, los fototipos 1 y 2, tener el cabello y los ojos claros, la ascendencia europea y el vivir en aéreas tropicales, entre otros. La patogénesis es compleja e involucra varias vías, entre las cuales están la apoptosis, las alteraciones del gen p53, las especies reactivas del oxígeno, el virus del papiloma humano, la inmunosupresión externa (medicamentos inmunosupresores) y la ocasionada por el sol.
Características epidemiológicas y clínicas de las onicomicosis causadas por Fusarium spp. en un centro de referencia de Bogotá, Colombia, 2001-2010
Authors: Morales Camilo Andrés , Solórzano Andrea , Rojas Aída Paola
Published: May 2019

Introducción. Fusarium spp. es uno de los agentes etiológicos de onicomicosis por mohos no dermatofitos aislados con mayor frecuencia en todo el mundo. Sin embargo, la información disponible sobre el tema es limitada y algunas veces contradictoria, probablemente debido al escaso número de casos informados. El objetivo del estudio fue describir las características epidemiológicas y clínicas de un grupo de pacientes con diagnóstico confirmado de onicomicosis por Fusarium spp. en un centro de referencia de Bogotá, Colombia.Materiales y métodos. Se llevó a cabo un estudio descriptivo de tipo corte transversal, en el que se describieron las características epidemiológicas y clínicas de los pacientes con diagnóstico confirmado de onicomicosis por Fusarium spp. que consultaron entre el 1° de enero de 2001 y el 31 de diciembre de 2010.Resultados. Se confirmaron 95 casos de onicomicosis por Fusarium spp. en 72 mujeres (76 %) y 23 hombres (24 %), con una edad promedio de 40 años. Ocho (8,4 %) tenían insuficiencia vascular, seis (6,3 %) hipotiroidismo, y dos (2,1 %) diabetes. Las presentaciones clínicas más frecuentes fueron la onicomicosis subungular distal y lateral en 71 pacientes (74,7 %) y la distrófica total en 10 pacientes (10,5 %). Se presentó un caso de infección mixta con Neoscytalidium dimidiatum.Conclusiones. La presentación clínica más frecuente de las onicomicosis por Fusarium spp. es la subungular distal y lateral, con cromoniquia de tonos blanco y amarillo, que puede ser indistinguible de las onicomicosis causadas por dermatofitos o por otros mohos. No se encontró relación con factores de riesgo que pueden predisponer a la infección.
Uso de jogos eletrônicos em artes visuais
Authors: Pereira Samuel Vilasbôas , Antonini de Souza Paulo César
Published: May 2019

ResumoO presente artigo reúne reflexões a partir de um estudo voltado para o ensino de artes visuais considerando as possibilidades pedagógicas do uso de jogos eletrônicos em espaços de ensino e de aprendizagem. Tendo por fundamento uma revisão de literatura sobre o fenômeno lazer e a natureza lúdica dos jogos no meio virtual, são realizadas análises de alguns jogos eletrônicos, destacando seus potenciais lúdicos e educativos, decorrentes de uma relação estética entre o jogador e o jogo, além de aspectos descritivos dos jogos. Realiza-se, por fim, um movimento que procura destacar os aspectos relevantes da utilização dos jogos eletrônicos como instrumento pedagógico para o ensino de artes visuais.Palavras-chave: Jogos Eletrônicos. Ensino de Artes Visuais. Lazer.Use of electronic games in visual artsAbstractThis paper presents reflections from a study related to the visual arts teaching considering the pedagogical possibilities of electronic games in teaching spaces and learning. Based on a literature review of the leisure phenomenon and the playful nature of the games in the virtual environment, analyzes of some electronic games are performed, emphasizing their playful and educational potential, also emphasizing descriptive aspects of the games. Finally, the relevant aspects of the use of electronic games as a pedagogical instrument for the teaching of visual arts are highlighted.Keywords: Electronic Games. Visual Arts Education. Leisure.Uso de juegos electrónicos en artes visualesResumenEl presente artículo reúne reflexiones a partir de un estudio orientado a la enseñanza de artes visuales considerando las posibilidades pedagógicas del uso de juegos electrónicos en espacios de enseñanza y de aprendizaje. Habiendo fundado en una revisión bibliográfica sobre el fenómeno del ocio y el carácter lúdico de los juegos en el entorno virtual, se realizan análisis de algunos juegos electrónicos, destacando sus potenciales lúdicos y educativos, que surgen de una relación estética entre el jugador y el juego, presentando también aspectos descriptivos de los juegos. Se realiza, por fin, un movimiento que busca destacar los aspectos relevantes de la utilización de los juegos electrónicos como instrumento pedagógico para la enseñanza de artes visuales.Palabras clave: Juegos Electrónicos. Enseñanza de Artes Visuales. Ocio.
Futebol: necessárias rupturas
Authors: Sérgio Manuel , Mizuno Lemos Fábio Ricardo
Published: May 2019

ResumoA intenção desse ensaio é apontar reflexões sobre o futebol, em sua possível relação com a motricidade humana, que considera o ser humano no constante movimento intencional da transcendência. Para isso, são sinalizadas algumas rupturas, entre elas: o ser humano que vivencia o desporto não é um ser mecânico, uma máquina, uma dicotomia corpo-mente, sentimentos-consciência, natureza-cultura; seus movimentos não são matematicamente explicados; o mundo não é um relógio. A complexidade humana é afirmada, os sentimentos considerados, para além das táticas e técnicas desportivas. A transformação do futebol é proposta (de mera atividade física à atividade verdadeiramente humana) a partir do desporto escolar e do desporto popular.Palavras-chave: Futebol. Ruptura. Motricidade Humana.Soccer: necessary rupturesAbstractThe aim of this essay is to point reflections on soccer and human motricity, which considers the human being in the constant intentional movement of transcendence. For this, some ruptures are signaled, among them: the human being who experiences sport is not a mechanical being, a machine, a dichotomy body-mind, feelings-consciousness, nature-culture; their movements are not mathematically explained; the world is not a clock. The human complexity is affirmed, the sentiments considered, besides the sports tactics and techniques. The transformation of soccer is proposed (from mere physical activity to truly human activity) from school sports and popular sport.Keywords: Soccer. Rupture. Human Motricity.Fútbol: necesarias rupturasResumenLa intención de este ensayo es apuntar reflexiones sobre el fútbol, en su posible relación con la motricidad humana, que considera al ser humano en el constante movimiento intencional de la trascendencia. Para ello, se señalan algunas rupturas, entre ellas: el ser humano que vivencia el deporte no es un ser mecánico, una máquina, una dicotomía cuerpo-mente, sentimientos-conciencia, naturaleza-cultura; sus movimientos no se explican matemáticamente; el mundo no es un reloj. La complejidad humana es afirmada, los sentimientos considerados, además de las tácticas y técnicas deportivas. La transformación del fútbol es propuesta (de mera actividad física a la actividad verdaderamente humana) a partir del deporte escolar y del deporte popular.Palabras clave: Fútbol. Ruptura. Motricidad Humana.
Inter-Relationship between Global Competitiveness and Human Development- Analytical Study of Selected Countries
Authors: Younis Mufeed Thinun , Omer Dina Ahmed
Published: May 2019

The research aims to study the inter-relationship between global competitiveness indicators and human development indicators for selected countries (low, middle, and high income)by using Granger Test, and VAR Test. The results of the causality test showed that there is a causality relation between international competitiveness and human development.

We found global competitiveness indicators has a clear effect on human development indicators in the low, middle, and high-income countries.
Effectiveness of SVRK Learning Model to Improve English Language Ability of Kahuripan Kediri University Agricultural Students
Authors: Suhaimi Imam , Mardatilla Indana
Published: May 2019

Tujuan penelitian ini yaitu untuk mengetahui kemampuan berbahasa Inggris mahasiswa setelah menggunakan model pembelajaran SVRK dalam pembelajaran bahasa Inggris bagi mahasiswa pertanian. Peneliti ingin mengetahui apakah model pembelajaran SVRK dapat meningkatkan kemampuan berbahasa Inggris mahasiswa Fakultas Pertanian Universitas Kahuripan Kediri. Sampel dalam penelitian ini berjumlah 19 mahasiswa yang berasar dari Fakultas Pertanian Universitas Kahuripan Kediri. Hasil penelitian menunjukkan bahwa diketahui t-value lebih tinggi dari t-critical = (7,935> 1,734). Dengan demikian dapat disimpulkan bahwa ada peningkatan yang signifikan terhadap kemampuan berbahasa Inggris mahasiswa setelah diajar menggunakan model pembelajaran SVRK. Untuk itu, peneliti memberikan rekomendasi untuk dapat menggunakan model SVRK pada pembelajaran kelas bahasa Inggris di fakultas pertanian khususnya dan mahasiswa pada program studi yang lain pada umumnya.
Survival of Firms in Crisis: Evidence from Antalya Tourism City
Authors: TÜRKCAN Kemal , ERKUŞ ÖZTÜRK Hilal
Published: May 2019

Firm survival in tourism cities has long been a
topic of discussion, due to particularly the fragile nature of the tourism
industry. Crises make tourism cities even more fragile, which makes them an
ideal case for studying the effects of crises on firm survival. Antalya,
Turkey's leading tourist destination, has suffered from economic and political
crises in recent years. This study investigates the factors influencing firm
survival in a crisis-ridden tourism city. The results of a time-discrete
survival analysis show that firm survival depends on firm-, industry-, and
location-specific factors. Business survival declines in times of downturns.
The survival rate is higher for smaller and younger firms and lower for corporate
firms. There are no differences between foreign owned and domestic firms.
The Impacts of Host Photos on Consumer Purchase Probability in P2P Short-Term Rental Platform: Mediating Effect of Initial Trust
Authors: WU Hui , CHEN Jing , CAVUSOGLU Muhittin , COBANOGLU Cihan
Published: May 2019

In recent years, the shared
housing rental platform (hereafter, the short-term rental platform), designed
to serve the Peer-2-Peer (P2P) market, has flourished and received extensive
attention from the business community and academia. However, few studies have
focused on the effect of hosts’ personal information on consumer purchase
behavior. This article selects the host’s photo as an entry point because of
its important position in the site interface and builds a conceptual framework
among host photo, reputation, initial trust, and consumer purchase probability
based on Face Processing Theory. Three-hundred valid, scenario-based
questionnaires were used for hypotheses testing. Results show that photo-based
social impression perception and reputation both help consumers form initial
trust, which ultimately affects consumer purchase probability；
photo-based perceived social impression has a greater impact on initial trust
and purchase probability than does reputation. Results will provide some
guidance for the marketing management of sharing platform organizations.
Improving the Quality of English Learning in Madrasah Tsanawiyah Muhammadiyah 10 Wukir at Wangen Using Lolly-Pop Card Media
Authors: Listianingrum Riskha Aprilia , Yuliarti Dwi , Yani Indah
Published: May 2019

The primary purpose of this article is to improve the quality of English learning process at MTs Muhammadiyah 10 Wukir by using Lolly-Pop Card media which is expected to make students more interested in learning English. In improving the quality of the learning process of English, the author also provides training in the making of learning media in the form of Lolly-pop Card. Participants who follow this English learning activity amounted to 6 people including formal educators. The results obtained after the training show that by using Lolly-pop Card media, the quality of English learning done by the teacher is better because it can improve the ability of learners in teaching activities and learners are more interested in learning English in the classroom. This is evidenced by the results of tests given after using Lolly-pop Card media. They are also more interested in learning to use Lollypop Card media so that the process of teaching and learning in the classroom is more active, fun, and not dull.
REVITALISASI MASJID PRODUKTIF
Authors: Hasbullah Hasbullah
Published: May 2019

Masjid Produktif adalah harapan kita semua, karena dari masjid akan melahirkan banyak kemajuan-kemajuan di segala bidang baik itu sosial, budaya, ekonomi dan lain-lain. Masjid produktif akan dapat diwujudkan dengan kesadaran bersama melalui berbagai kegiatan dan komunikasi aktif baik pengurus masjid maupun jama’ah masjid secara bersamaan dengan saling bahu membahu. Masjid juga merupakan wadah yang paling strategis dalam membina dan menggerakkan potensi umat Islam untuk mewujudkan Sumbar Daya Manusia yang tangguh dan berkualitas. Sebagai pusat pembinaan umat, eksistensi masjid kini dihadapkan pada berbagai perubahan dan tantangan yang terus bergulir di lingkungan masyarakat. Maka Masjid Produktif adalah merupakan upaya secara sistematis dan berlangsung secara terus menerus untuk menyadarkan dan memberdayakan umat dengan berbagai aktivitas yang islami. Untuk mencapai hasil yang optimal perlu didukung dengan sistim, aktivitas dan lembaga pemberdayaan Masjid. Artikel ini merupakan hasil penelitian terhadap beberapa masjid yang ada di Kota Jambi, yang peneliti acak menurut kecamatan yang ada di kota Jambi, penentuan lingkup penelitian ini adalah merupakan hasil observasi terhadap masjid-masjid yang penulis anggap telah berusaha untuk meuwujudkan dan merevitalisasi masjid yang produktif dengan berbagai aktifitas khususnya dalam hal pemberdayaan ekonomi umat, bentuk dan jenis penelitian adalah kualitatif dengan observasi dan wawancara.
PLURALISME DAN DIALOG ANTAR AGAMA
Authors: Halim Abdul
Published: May 2019

Kemajemukan atau yang lebih dekat dengan sebutan pluralisme, di satu sisi menjadi khazanah budaya bangsa yang terus haras terjaga. Jika agama merupakan bagian dari khazanah budaya bangsa dengan nilai-nilai keberagamaan pemeluknya masing-masing, maka sisi lain harus diwaspadai adalah konflik atau ketegangan yang terjadi akibat persentuhan antara nilai-nilai suatu agama dengan nilai-nilai agama lain yang sangat dipengaruhi oleh individu-individu pemeluk masing-masing agama. Dalam hal ini terdapat kecenderungan penganut masing-masing agama untuk memuliakkan bentuk-bentuk tertentu dari agamanya sehingga agama itu menjadi tertutup atau yang kita kenal dengan sikap keberagamaan yang ekslusivistis, dimana hubungan timbal balik antara agama dan situasi sosialnya menjadi macet dan tidak harmonis, padahal agama berbubungan dengan sesuatu yang dianggap ilahi atau mutlak, dengan sendirinya agama itu mestinya memandang dirinya sendiri (dengan segala ajaran, upacara, perilaku keagamaan pemeluknya, dan lain-lain) sebagai hal yang bersifat lelatif dan tidak mutlak.