bluuebunny/crossref_metadata_2025 huggingface dataset:
Image Steganography
Authors: Patil Pratham , Sonawane Joshil , More Tejas , Shelvane Prashant , Bankar Prof. Ms. Jaitee
Published: May 2022

Abstract: The behavior of posting pictures on social network structures is befell everywhere and every single 2nd. for this reason, the conversation channels supplied through various social networks have a remarkable potential for covert verbal exchange. however, photos transmitted through such channels will typically be JPEG compressed, which fails most of the prevailing steganographic schemes. in this paper, we advise a singular photograph steganography framework this is robust to such channels. specifically, we first reap the channel compressed version (i.e., the channel output) of the unique picture. secret data is embedded into the channel compressed original photo by the use of any of the prevailing JPEG steganographic schemes, which produces the stego-image after the channel transmission. To generate the corresponding image earlier than the channel transmission (termed as the intermediate photograph), we recommend a coefficient adjustment scheme to barely regulate the authentic image based totally at the stego- image. The adjustment is carried out such that the channel compressed version of the intermediate photo is precisely similar to the stego-picture. therefore, after the channel transmission, the secret facts may be extracted from the stego-photo with 100Various experiments are conducted to reveal the effectiveness of the proposed framework for image steganography sturdy to JPEG compression. Keywords: Steganograpghy, Data hiding, Security, Image Steganogrpghy
A 7-year-old Boy with Orchitis after COVID-19 Infection
Authors: Ghaffaripour Hossein Ali , Sadati Elham , Haseli Sara , Mahdaviani Seyed Alireza , Daneshmandi Zahra , Velayati Ali Akbar , Honarpisheh Parisa
Published: May 2022

Although most manifestations of coronavirus infection in children are
mainly related to the respiratory and gastrointestinal organs,
involvement of other organs has also been seen with less prevalence.
Because of the expression of virus receptors in male genitalia, this
system is regarded as a potential target for this virus.
Approximate controllability of non-instantaneous impulsive fractional neutral measure evolution systems with state-dependent delay
Authors: Liu Yongyang , Liu Yansheng
Published: May 2022

This paper is concerned with the existence of mild solutions and
approximate controllability for a class of noninstantaneous impulsive
fractional neutral measure evolution systems with state-dependent delay.
First, the existence of mild solutions for the considered system is
obtained by using Kuratowski’s measure of noncompactness and the set
contraction fixed point theorem. Next, under the assumption that the
correlated linear system is approximately controllable, the approximate
controllability of the system is studied. Finally, we present two
applications to support the practical usefulness of the study
Spontaneous thrombus migration during mechanical thrombectomy : A case report
Authors: Charles Jude
Published: May 2022

Mechanical thrombectomy is the standard of care for acute large vessel
occlusion stroke since 2015 . Many studies report pre-intervention
distal thrombus migration, especially after intravenous thrombolysis. We
report a case of spontaneous intraprocedural thrombus migration during
mechanical Thrombectomy with a review of conditions favoring the
phenomenon.
Simultaneous Screening of Zebrafish Larvae Cardiac and Respiratory Functions: A Microfluidic Multi-Phenotypic Approach
Authors: Khalili Arezoo , Wijngaarden Ellen van , Zoidl Georg , Rezai Pouya
Published: May 2022

Multi-phenotypic screening of multiple zebrafish larvae plays an
important role in enhancing the quality and speed of biological assays.
Many microfluidic devices have been presented for zebrafish phenotypic
assays, but multi-organ screening of multiple larvae, from different
needed orientations, in a single device that can enable rapid and
large-sample testing is yet to be achieved. Here, we propose a
multi-phenotypic quadruple-fish microfluidic chip for simultaneous
monitoring of fin movement and heart activity of 5–7-day
postfertilization zebrafish larvae trapped in the chip. In each
experiment, fin movements of four larvae were quantified in the dorsal
view in terms of fin beat frequency (FBF). Positioning of four optical
prisms next to the traps provided the lateral views of the four larvae
and enabled heart rate (HR) monitoring. The device’s functionality in
chemical testing was validated by assessing the impacts of ethanol on
heart and fin activities. Larvae treated with 3% ethanol displayed a
significant drop of 13.2% and 35.8% in HR and FBF, respectively.
Subsequent tests with cadmium chloride highlighted the novel application
of our device for screening the effect of heavy metals on cardiac and
respiratory function at the same time. Exposure to 5 μg/L cadmium
chloride revealed a significant increase of 8.2% and 39.2% in HR and
FBF, respectively. The device can be employed to improve quantitative
multi-phenotypic screening of zebrafish larvae in response to chemical
stimuli in various chemical screening assays, in applications such as
ecotoxicology and drug discovery.
Giant spleen as a surgical challenge: Case report and literature review
Authors: Eric Dragan , Tadic Boris , Grubor Nikola , Toskovic Borislav , Milosavljevic Vladimir
Published: May 2022

Introduction. According to the guidelines of the European Association of Endoscopic Surgery, any case where the maximum craniocaudal splenic diameter exceeds 20 cm is considered massive splenomegaly. In addition to metabolic, hematological, and hemodynamic problems, enlarged spleen may cause mechanical difficulties due to the pressure to surrounding organs and vascular structures. The aim of this paper is to present the surgical challenges and technique applied in massive splenomegaly, in a patient who had neglected the importance of regular medical checkups. Case outline. We present a 62-year-old male patient who was admitted to hospital for treatment of previously clinically and radiologically verified splenomegaly but who neglected the importance of regular checkups and medical treatment. Splenectomy was performed with a splenic specimen 38 cm in its maximal diameter. Conclusion. Taking into consideration all the possible benefits and possible complications of surgical treatment, including the quality of life of splenectomized patients, comprehensive preoperative assessment should be made, and surgical treatment selectively applied.
The p66Shc protein mediates insulin resistance and secretory dysfunction in pancreatic beta-cells under lipotoxic conditions
Authors: Biondi Giuseppina , Marrano Nicola , Dipaola Lucia , Borrelli Anna , Rella Martina , D’Oria Rossella , Genchi Valentina A. , Caccioppoli Cristina , Porreca Immacolata , Cignarelli Angelo , Perrini Sebastio , Marchetti Piero , Vincenti Leonardo , Laviola Luigi , Giorgino Francesco , Natalicchio Annalisa
Published: May 2022

 We evaluated the role of the p66Shc redox adaptor protein in pancreatic beta-cell insulin resistance that develops under lipotoxic conditions and with excess body fat. Prolonged exposure to palmitate in vitro or the presence of overweight/obesity augmented p66Shc expression levels and caused an impaired ability of exogenous insulin to increase cellular insulin content and secreted C-peptide levels in INS-1E cells and human and murine islets. In INS-1E cells, p66Shc knockdown resulted in enhanced insulin-induced augmentation of insulin content and C-peptide secretion and prevented the ability of palmitate to impair these effects of insulin. Conversely, p66Shc overexpression impaired insulin-induced augmentation of insulin content and C-peptide secretion both in the absence and presence of palmitate. Under lipotoxic condition, the effects of p66Shc are mediated by p53-induced increase in p66Shc protein levels and JNK-induced p66Shc phosphorylation at Ser36 and appear to involve the phosphorylation of the ribosomal protein S6 kinase at Thr389 and of insulin receptor substrate-1 at Ser307, resulting in the inhibition of insulin-stimulated protein kinase b phosphorylation at Ser473. Thus, the p66Shc protein mediates the impaired beta-cell function and insulin resistance induced by saturated fatty acids and excess body fat. 
Mengembangkan Kemampuan Berpikir Matematis Tingkat Tinggi Siswa Melalui Blended Learning Berbantuan Geogebra
Authors: Supriadi Nanang
Published: May 2022

Blended Learning telah mendapat perhatian yang cukup besar dalam dunia pendidikan matematika beberapa tahun terakhir, pembelajaran ini menggabungkan antara pembelajaran berbasis online dan tatap muka. Pembelajaran Blended Learningdilandasi dari beberapa kelemahan yang terdapat dalam pembelajaran e-learning, diantara kelemahan tersebut ialah tidak adanya interaksi sosial antara siswa dan guru; sulit untuk melibatkan seluruh siswa dalam diskusi yang bermakna dan produktif; dan e-learning cenderung hanya cocok untuk siswa dengan kemauan belajar mandiri yang kuat dan motivasi yang tinggi.

Pembelajaran online merupakan sesuatu yang tidak terpisahkan dalam Blended Learning, sehingga seharusnya pembelajaran online bukan sekedar media yang hanya menempatkan bahan ajar, tugas, soal latihan, tes, serta alat pengirim hasil pekerjaan siswa saja. Pembelajaran online sedapat mungkin memiliki tampilan yang menarik dan atraktif agar siswa lebih memahami tujuan pembelajaran yang disampaikan. Salah satu alat bantu untuk mengembangkan pembelajaran online yang menarik dan atraktif ialah menggunakan opensource softwarebernama Geogebra, dengan software ini kita tidak harus membayar lisensi untuk menggunakannya dan terdapat fasilitas export yang dibutuhkan dalam membangun sebuah website.

Pembelajaran menggunakan Blended Learningdalam mata pelajaran matematikapada umumnya digunakan hanya sebatas pada peningkatan pemahaman siswa saja, hal ini sangat disayangkan mengingat kelebihan yang dimilikinya. Model pembelajar Blended Learning sesungguhnya sangat baik digunakan untuk mengembangkan kemampuan berpikir matematis siswa ke arah yang lebih tinggi, tidak sekedar hanya mengharapkan siswa paham pada materi-materi yang disajikan.
Peran Kemampuan Berpikir Dalam Proses Pembelajaran Matematika
Authors: Leonard Leonard
Published: May 2022

Penelitian ini bertujuan untuk menganalisis tentang peran kemampuan berpikir terhadap prestasi belajar mata kuliah evaluasi pendidikan. Kemampuan berpikir dalam penelitian ini meliputi kemampuan berpikir lateral dan kemampuan berpikir positif. Penelitian ini adalah penelitian survei korelasional, dengan populasi mahasiswa pendidikan matematika UNINDRA. Sampel diambil dengan teknik multistage random sampling sejumlah 60 orang. Instrumen yg digunakan adalah angket dan tes yang telah divalidasi sebelumnya. Analisis data menggunakan regresi berganda, dengan terlebih dahulu menguji normalitas, linieritas dan multikolonieritas. Dari pengolahan data diperoleh hasil: 1) terdapat pengaruh kemampuan berpikir lateral terhadap hasil belajar evaluasi, 2) terdapat pengaruh kemampuan berpikir positif terhadap kemampuan berpikir positif, dan 3) terdapat pengaruh kemampuan berpikir lateral dan kemampuan berpikir positif secara bersama-sama terhadap hasil belajar evaluasi.
Peningkatan Kemampuan Penalaran Matematik Siswa Melalui Pendekatan Keterampilan Proses Matematika
Authors: . Juariah
Published: May 2022

Pendekatan pembelajaran diupayakan harus dapat mengaktifkan siswa, dan mengembangkan kemampuan memecahkan masalah serta daya nalar siswa, sehingga siswa mampu mengembangkan dan mengevaluasi argumentasi. Salah satu pendekatan yang bisa melibatkan berbagai aktivitas siswa adalah pendekatan keterampilan proses. Proses pengajaran dengan keterampilan proses akan membentuk siswa yang terampil dalam intelektual dan terampil dalam proses perhitungan. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan pendekatan keterampilan proses matematika dalam meningkatkan kemampuan penalaran siswa MTs.N 1 Kota Bandung. Metode penelitian yang digunakan adalah metode eksperimen, dengan Disain penelitian  yang digunakan berbentuk pretest-postest-control group, yaitu disain kelompok kontrol pretes dan postes yang melibatkan dua kelompok. Dua kelompok tersebut, yaitu kelompok kontrol dan kelompok eksperimen. Perbedaan antara kedua kelompok tersebut adalah perlakuan dalam proses belajar-mengajar. Eksperimen proses belajar-mengajarnya memperoleh perlakuan dengan pendekatan keterampilan proses matematika, sedangkan kelompok kontrol memperoleh pengajaran biasa. Hasil penelitian ini menunjukkan bahwa  Terdapat perbedaan peningkatan kemampuan penalaran matematis antara siswa yang mendapat pembelajaran dengan pendekatan keterampilan proses matematika dan siswa yang mendapat pembelajaran biasa. Kemampuan penalaran matematis siswa yang mendapat pembelajaran dengan pendekatan keterampilan proses matematika lebih baik dibandingkan siswa yang mendapat pembelajaran biasa. Dengan demikian pembelajaran matematika siswa dengan pendekatan keterampilan proses  dapat meningkatkan kemampuan penalaran matematis siswa.
Pengembangan Bahan Reflective ThinkingAjar dan Instrumen untuk Meningkatkan Berpikir Reflektif Matematis dan Kemandirian Belajar Berbasis Pendekatan Metakognitif
Authors: Hepsi Hepsi
Published: May 2022

This study mathematical background of reflective thinking skills are very important role in mathematical problem-solving activities. Based on the results of a preliminary study, 60% contained one high school students Tangerang district in Banten still weak in several indicators reflective mathematical thinking skills. In addition to reflective thinking that will be developed there to learn independence. Reflective mathematical thinking and independence associated with learning one's metacognitive abilities. Metacognitive ability is an ability that aware of his thinking, the ability to see herself so that what is done can be controlled optimally. The purpose of this study is to produce teaching materials and instruments and columns based learning approach to enhance metacognitive reflective mathematical thinking and learning independence. This research method using the method development. Its activities include preliminary studies (literature search, observation, interviews with teachers), product development (teaching materials and instruments and columns, test experts (mathematicians and mathematics education), Test 3 is limited to students in high school in Tangerang district belonging to high school, moderate and low. This study concluded that the teaching materials, instruments ability to think mathematically and learn self-reliance scale feasible for use. Instruments reflective mathematical thinking has 8 indicators with 11 questions and independence Scale consists of nine indicators with a 40 item statements.
Centenario del partido: tendencias y sobresaltos durante 2021 en China
Authors: Haro Navejas Francisco Javier
Published: May 2022

Este trabajo sobre China y Hong Kong durante 2021 cubre apenas algunos aspectos de lo acontecido en su seno o de aquello que les afectó. El eje del texto es el evento político principal del año: el centésimo aniversario del Partido Comunista Chino (PCC). Alrededor de esta celebración se ordenaron los discursos y las acciones de la élite política dominante en China, entre los que sobresalen todos los eventos realizados para celebrar la fundación del partido y la liberación de Meng Wanzhou en Canadá, para no hablar de cada uno de los discursos de Xi Jinping, presidente y secretario general del PCC. Se describen parcialmente las crisis de un gigante de bienes raíces y la de la generación de energía, temas encuadrados dentro de las previsiones que se presentaron públicamente sobre los acontecimientos que podrían haberse avecinado. El artículo examina diferentes aspectos de las relaciones internacionales de China con algunos países de las Américas, entre ellos Canadá, Estados Unidos, México y algunos de América del Sur, como Brasil, Chile y Ecuador. Dado el contexto actual, se presta atención relevante a las relaciones con Australia y los cambios que se producen en el statu quo de la región. La demografía es un tema clave en el texto, que analiza el censo de 2020, cuyos resultados fueron dados a conocer en 2021. Otros aspectos presentes incluyen el mundo laboral, el cine y la política dentro de la industria de la moda. En el caso de Hong Kong se abordan las secuelas de la Ley de Seguridad Nacional y la aprobación de las reformas a la ley electoral, así como las propuestas económicas para poner esta región administrativa especial sobre sus pies.
Tailandia
Authors: Ramírez Didou Pablo Henri
Published: May 2022

2021 ha sido un año complicado para Tailandia. La pandemia del coronavirus, que parecía dominada en 2020, terminó por afectar todos los aspectos de la vida tailandesa. El gobierno de Prayuth Chan-o-cha ha tenido que enfrentar la gestión sanitaria de la pandemia, la crisis política que ésta ha ocasionado en el país, el movimiento estudiantil que busca una reforma social y política, así como las tensiones existentes entre sus socios regionales de la ASEAN y la guerra comercial entre China y Estados Unidos.
Tortura policial: más allá de “confesiones” para el sistema de justicia penal
Authors: Silva Forné Carlos , Padilla Oñate Sergio
Published: May 2022

El análisis de la tortura ejercida por policías en México se ha centrado en su relación con el sistema de justicia penal. Sin embargo, las policías desarrollan otros objetivos y ámbitos de actuación donde la tortura también puede ser una práctica común. Utilizando la Encuesta Nacional de Población Privada de la Libertad se construyeron modelos de regresión logística para probar dos motivaciones alternativas: la extracción de renta y la imposición de castigos. Los resultados confirman la importancia de explicaciones de la tortura que trasciendan la perspectiva del sistema de justicia penal y den cuenta de la complejidad formal e informal de la acción policial. Finalmente, discutimos los límites de los resultados y sugerimos nuevas rutas de investigación.
Subcontratación y precarización del empleo: los accidentes laborales en la industria petroquímica
Authors: Fernández Massi Mariana
Published: May 2022

La difusión de la subcontratación ha repercutido en la calidad del empleo, lo que ha generado condiciones de trabajo diferenciales para trabajadores directos y subcontratados. El presente artículo aborda una dimensión específica del empleo: la seguridad laboral de los trabajadores subcontratados. La investigación indaga en los motivos que esgrimen los trabajadores del sector petroquímico en Argentina para explicar la recurrencia de accidentes más graves entre trabajadores subcontratados. A partir de entrevistas realizadas a trabajadores del sector se identificaron cuatro conjuntos de explicaciones: capacitación insuficiente sobre el manejo de riesgos que reciben y falta de concientización sobre los recaudos necesarios; deficiencias en la calidad de los elementos de seguridad utilizados; la propia naturaleza de las actividades externalizadas, y la falta de protección sindical.
Ensambles entre el activismo neoconservador y el neoliberalismo: mirada desde el sur
Authors: Morán Faúndes José Manuel
Published: May 2022

En este artículo se exploran las razones que esgrime públi­camente el neoconservadurismo para promover su agenda moral articulada con agendas neoliberales. Se analizaron las propuestas de partidos políticos “pro-vida”/“pro-familia” en Chile, Brasil, Argentina y Perú, y contenidos producidos por divulgadoras/es de ideas neoconservadoras en Sudamérica. Se proponen tres categorías que sintetizan los prin­cipales modos en que se realiza la articulación neoconservadora-neoliberal: un “ensamble funcional” que entiende que la tradición es funcional al orden del mercado y la libertad; un “ensamble subsidiario” que entiende que la retirada del Estado implicaría un fortalecimiento de instituciones subsidiarias, como la familia patriarcal, y un “ensamble defensivo” que asume que toda intervención estatal, incluidos los derechos sexuales y reproductivos, responde a una agenda neo-marxista.
Difference-in-differences test for micro effect of technological finance cooperation pilot in China
Authors: Li Guiping , Liu Wei
Published: May 2022

By establishing difference in differences (DID) and propensity score matching-double difference method (PSM-DID) models, the paper investigates the effect of the two pilot policies which promotes the combination of technology and finance based on the enterprise value with the available data from Shanghai and Shenzhen A-share listed companies in China from 2008 to 2019. Empirical results show that the first and second pilots of technological finance cause a significant increase and decrease in the enterprise value, respectively. These conclusions validate the effectiveness of China's technological finance policy from the enterprise value and provide empirical data support for optimising technological finance policies of the government and high-quality development of enterprises in the new era.
Interprofessional Roles and Collaborations to Address COVID-19 Pandemic Challenges in Nursing Homes
Authors: Kang Yu Jin , Monsen Karen , Jeppesen Betsy , Hanson Candy , Nichols Kathie , O'Neill Kelly , Lundblad Jennifer
Published: May 2022

Nursing home experts and informatics nurses collaborated to develop guidelines for nursing homes that revealed partnership principles in action during the COVID-19 pandemic. This article describes efforts to define interprofessional nursing home staff roles within the partnership-based COVID-19 Response Guideline, and to examine changes in nursing practice compared to the pre-pandemic practice of nurses. The qualitative process of identification of nursing home staff roles revealed the extensive scope of interprofessional partnership needed to respond to the pandemic. Using the Omaha System structure, we compared these collective COVID-19 response interventions of Nursing Service roles with nursing interventions of RNs and LPN/LVNs defined in previous nursing home studies. This comparison showed the necessary transformation and collaboration among nurses needed for the pandemic response in nursing homes. The Omaha System Pandemic Guideline is available online and in the Omaha System Guidelines app for immediate use as COVID-19 response practice guidelines and references for interprofessional roles in nursing homes, as well as for multidisciplinary roles across diverse care settings. The guideline is an exemplar of how informatics can facilitate interprofessional and multidisciplinary partnership for nursing homes and other care settings. Future use of the guidelines for decision making and documentation related to infection prevention and control in nursing homes may improve care quality and health outcomes of residents and population.
The results of the index comparative evaluation of photodynamic therapy and ultraviolet irradiation in the treatment of chronic gingivitis
Authors: Losev K. V. , Kostyakova T. V. , Batsula N. V. , Verendeeva M. A. , Kuzina O. V. , Losev A. V.
Published: May 2022

In this clinical study, the effect of photodynamic therapy and ultraviolet radiation on the effectiveness of the treatment of periodontal diseases was examined according to the results of an index assessment. Clinical examination of 95 patients of both sexes aged from 18 to 32 years revealed chronic generalized catarrhal gingivitis (K05.1). The main index criteria for comparative parameters in all study groups were: simplified OHI-S hygiene index, Mullemann-Cowell bleeding index, PMA index. The indices were measured before and after treatment with subsequent control examinations in 1 month, 3 months, 6 months. The patients were divided into three groups and each group underwent standard periodontal treatment aimed at stopping the inflammatory process and preventing its further development. In the first group, the treatment was supplemented with the use of the FotoSan LED lamp with a wavelength of 630 nm, in the second the “Quasar” ultraviolet irradiator was used, in the third (control) group, the complex of therapeutic measures was carried out without physiotherapeutic procedures. According to the results of the study, the use of photodynamic therapy significantly accelerates the regenerative processes of periodontal epithelial tissue and reduces the number of treatment sessions.
Museum and Kindergarten: STEM connections between exhibits and science
Authors:   7th Kindergarten of Ioannina, Ioannina, Greece, Tallou Konstantina
Published: May 2022

The present work supports the possibility of connecting exhibits of the Museum of Ali Pasha on the island of Ioannina with the Natural Sciences through an educational scenario in the light of the Theory of Activity and the SciEPIMGI design framework. In this way the educational programs designed for Museums of general interest gain added value by supporting the cooperation of formal and non-formal education. The script was designed during the training program of the University of Ioannina and was implemented in November 2021 by students of the Kindergarten of Ioannina. Through selected exhibits of the Museum, bridges with themes were detected from the Curriculum for Natural Sciences in the Kindergarten, focusing specifically on the theme "water". Theoretically, it is based on the approach of Hein's constructivism, Gardner's multiple intelligences and the active participation of Simon's student, with particular emphasis on the student's individual peculiarities regarding the ways of perceiving reality and the personal meanings he forms. The Museum-pedagogical activities that are designed apply a variety of methodologies such as students' oral expression, visual creations, hidden treasure game, writing, experimentation, creating connections, problem solving, interpretation and expression of crises, etc. Special emphasis was given to of students' senses and in experiential and exploratory learning. The museum space was utilized as a constructed environment for learning and application of museum-pedagogical methods and as an invisible educational framework that allows effective learning processes, mobilizes curiosity, evokes emotions and impressions.
Investigation of the clinical efficacy and safety of herbal Algan Hemostatic Agent in coronary artery bypass graft surgery
Authors:   DEPARTMENT OF CARDIOVASCULAR SURGERY, KOŞUYOLU HIGH SPECIALIZATION EDUCATION AND RESEARCH HOSPITAL, ISTANBUL, TURKEY, Kırali Kaan , Adademir Taylan , Dayıoğlu Nurten
Published: May 2022

Background. Hemostatic agents have the potential to improve clinical outcomes by decreasing postoperative drainage and the need for transfusions. Algan Hemostatic Agent is a polysaccharide-based hemostatic agent obtained from a mixture of six different herbs. The aim of this study is to investigate the clinical efficacy and safety of Algan Hemostatic Agent as a local hemostatic agent in coronary artery bypass operations. Methods. 28 subjects who underwent isolated coronary artery bypass graft surgery and met the inclusion criteria were included in this clinical study. Traditional methods (cautery, ligation, etc.) were used in the control group, whereas Algan Hemostatic Agent was added in the study group. A sponge soaked in Algan Hemostatic Agent liquid was lightly compressed to the bleeding area for 120 seconds. Results. Both groups were comparable in terms of preoperative demographic data and perioperative laboratory values. Drainage on the postoperative first day (650 ml vs 896 ml; p=0.381) and total drainage (817 ml vs 1210 ml; p=0.031) were found higher in the control group. Another significant difference was observed between the groups in terms of erythrocyte suspension utilization rate (1.14 U in the treatment group and 2.06 U in the control group, p=0.004). Algan Hemostatic Agent did not cause any complications during administration. Conclusion. In conclusion, Algan Hemostatic Agent has been found effective and safe in controlling bleeding during coronary artery bypass operations.
The fetal and maternal outcomes related to previous number of cesarean sections and uterus sparing surgery in women with abnormal placentation
Authors: Dogru Sukran , Akkus Fatih , Atci Aslı Altinordu , Eren Gulnur , Acar Ali
Published: May 2022

Objectives. We aimed to study the number of previous cesarean sections in cases diagnosed with placenta previa (PP) and placenta accreta spectrum (PAS), and maternal and fetal results in cases where we performed uterus-sparing surgery. Materials and Methods. PAS patients diagnosed with PP (PPAS) were included in this retrospective study. Postoperative hemogram values, blood transfusion amounts, hospitalization days, intraoperative and postoperative complication rates of all patients, APGAR scores (5-minute), mortality rates and birth weights were registered for all newborns on admission to the intensive care unit. Results. A total of 122 pregnant women were included in the study. In the comparison of hospitalization rates, there was a significant difference between CS ≤1 and CS =2 (p=0.01). When postoperative hemoglobin values were compared, there was significant difference between CS ≤1 and CS ≥3 (p<0.01). Neonatal intensive care admission rates increase as the number of CS increases. Conclusions. Uterus-sparing surgery in experienced clinics seems to be applicable, even if maternal and fetal morbidity increases. We suggest to consider CS numbers in PPAS group for fetal and maternal wellness while doing surgical planning.
A comparative study of wound opening versus primary closure after fistulectomy in the lower anal fistula
Authors:   DEPARTMENT OF SURGERY, KARNATAKA INSTITUTE OF MEDICAL SCIENCES, HUBLI, KARNATAKA, INDIA, Hiregoudar Abhijit D. , Yalagachin Gurushantappa , Mashal Sanjay B. , Shivaramu Naveena G.
Published: May 2022

Objectives. The aim of the study is to investigate the outcome of primary wound closure versus non-wound closure after fistulectomy in terms of postoperative pain and wound healing time. Materials and Methods. A prospective comparative randomized study was performed on patients admitted to the General Surgery Department of our Institute (Dec.1, 2019-Nov.31, 2021), with a diagnosis of low anal fistula and undergoing fistulectomy. 54 patients were included in the study and were assigned alternately and equally in group A (fistulectomy with laying open of wound) and group B (fistulectomy with primary closure), with 27 patients in each group. On day 1 postoperatively, the pain score was assessed by analog visual scale. Patients were followed for 6 weeks, and healing was assessed by visual examination of epithelialization at each follow-up visit. Results. In our study, the average healing time in group A was 20.77 days and in group B 14.07 days (the average healing time in group B is significantly longer than in group A, with P value of <0.00001). In our study, the average pain score among the participants in group A is 4, and among the participants in group B it is 2,148, with the value P <0.00001, which is statistically significant. Conclusion. Primary closure fistulectomy is a better method for treating low anal fistula due to the fact that it causes less pain, accelerated healing compared to wound opening fistulectomy. However, further studies are needed to compare other methods of treating low anal fistula.
Accurate Numerical Solution of Infrared Radiation Signature from Aircraft Plume
Authors: Cheng Wen
Published: May 2022

The temperature of aircraft plume varies greatly due to the large amount of high-temperature gas generated by the aeroengine. At present, the narrowband models are widely used to calculate the infrared radiation signature of the aircraft plume. However, the classical narrowband models make large errors when applied to the gas with large thermal gradient. To improve the accuracy of calculation, the classical Malkmus narrowband model was extended based on the idea of fictitious gas. The radiation characteristic parameters of [Formula: see text], and [Formula: see text] mixture at different temperatures were calculated using the classical Malkmus narrowband model and the extended model, respectively. Compared with the classical Malkmus narrowband model, the calculated results of the extended model are obviously in better agreement with the measured data. Based on the extended Malkmus narrowband model, a line-of-sight method was used to calculate the infrared radiation signature of aircraft plume. And the infrared radiation intensity of the plume of a scaled aeroengine nozzle was calculated. The results showed that the relative error between the calculated intensity and the measured data is [Formula: see text].
Fisiopatologia e tratamento da artrite reumatoide: uma revisão narrativa
Authors: Augusto Mateus Facklam , Silva Rhuan Victor Moreira da , Miquelito Juliana Teixeira , Freitas Karine Grillo de , Ferreira Victor Lucas , Viana Felipe Gomes Almeida , Carvalho Déborah Batista de , Medeiros Filho Anderson , Siqueira Emílio Conceição de
Published: May 2022

Objetivo: Revisar de forma didática a fisiopatologia e tratamento da Artrite Reumatoide (AR). Revisão bibliográfica: A AR é uma doença inflamatória crônica de caráter autoimune que se apresenta como uma poliartrite simétrica. Têm uma prevalência mundial e do Brasil de aproximadamente 1%. A fisiopatologia da AR está ligada à presença de um antígeno específico artritogênico que faz uma ativação de linfócitos T, que juntamente às citocinas inflamatórias liberadas, causam a doença. O diagnóstico da AR é feito através da clínica com a ajuda dos critérios criados pelo Colégio Americano de Reumatologia. O Fator Reumatoide (FR) e o Anticorpo Antipeptídeo Citrulinado (anti-CCP) apresentam grande importância no diagnóstico da AR. A primeira linha de tratamento da AR são as Drogas Antirreumáticas Modificadoras do curso da Doença (DMARDs) em monoterapia ou juntamente aos Anti-inflamatórios Não Esteroidais (AINEs), analgésicos e/ou glicocorticoides. Considerações finais: A AR é uma patologia com uma complexa fisiopatologia. É necessário seu rápido diagnóstico para o melhor tratamento para o paciente.
Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
Authors: Keller Michelle , Schira Kristina , Scheuermann Jörg
Published: May 2022

DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies. With this perspective we would like to summarize the development of DEL technology and present some representative DEL-derived hits which may soon enter the pharmaceutical market.
Generating Bioactive Natural Product-inspired Molecules with Machine Intelligence
Authors: Schneider Petra , Altmann Karl-Heinz , Schneider Gisbert
Published: May 2022

The computer-assisted design of new chemical entities has made a leap forward with the development of machine learning models for automated molecule generation. The overarching goal of this conceptual approach is to augment the creativity of medicinal chemists with a machine intelligence. In this Perspective we highlight prospective applications of “de novo” drug design and target prediction, aiming to generate natural product-inspired bioactive compounds from scratch. A virtual chemist transforms pharmacologically active natural products into new, easily synthesizable small molecules with desired properties and activity. Computational activity prediction and automated compound generation offer the possibility to systematically transfer the wealth of pharmaceutically active natural products to synthetic small molecule drug discovery. We present selected prospective examples and dare a forecast into the future of natural product-inspired drug discovery.
Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues
Authors: Thames Joy E. , Seley-Radtke Katherine L.
Published: May 2022

Over the past two and a half years the world has seen a desperate scramble to find a treatment for SARS-CoV-2 and COVID. In that regard, nucleosides have long served as the cornerstone to antiviral treatments due to their resemblance to the naturally occurring nucleosides that are involved in numerous biological processes. Unlike other viruses however, it was found early on during the search for drugs to treat SARS-1 and later MERS, that the coronaviruses possess a unique repair enzyme, an exonuclease (ExoN)[3] which rendered nucleoside analogues useless, thus negating their use.[4] During the current outbreak however, as both well-known and new nucleoside analogues were investigated or reinvestigated as a possible cure for SARS-CoV-2, several novel and/or lesser-known mechanisms of action were uncovered. This review briefly describes these mechanisms.
The Role of Transporters in Future Chemotherapy
Authors: Huttunen Johanna , Huttunen Kristiina M.
Published: May 2022

The expression of membrane transporter is often altered in cancer cells compared to their corresponding healthy cells. Since these proteins, classified into solute carriers (SLCs) and ATP-binding cassettes (ABCs), can carry not only endogenous compounds, nutrients, and metabolites, but also drugs across the cell membranes, they have a crucial role in drug exposure and clinical outcomes of chemotherapeutics. Curiously, up-regulation of SLCs can be exploited to deliver chemotherapeutics, their prodrugs, and diagnostic radio-tracers to gain cancer cell-selective targeting, as exemplified with L-type amino acid transporter 1 (LAT1). SLCs can also be inhibited to limit the nutrient uptake of cancer cells and thus, cell growth and proliferation. Furthermore, LAT1 can be utilized to deliver ABC-inhibitors selectively into the cancer cells to block the efflux of other chemotherapeutics suffering from acquired or intrinsic efflux transport-related multidrug resistance (MDR). Taking into account the current literature, compounds that can affect transporter up- or down-regulation of transporters in a cancer cell-selective manner could be a valuable tool and promising chemotherapy form in the future.
Robinia pseudoacacia (Black Locust) – An Invasive Species with Unsuspected Potential in Grappa Ageing
Authors: Fuchsmann Pascal , Tena Stern Mireille , Petignat-Keller Sonia , Inderbitzin Jonas , Bertogliati Mark , Cléroux Marilyn , Bach Benoit
Published: May 2022

No abstract.
Perbandingan pengaruh bola standar dan bola modifikasi terhadap kemampuan dribble sepakbola
Authors: Jatmiko Setia Dwi , Harmono Setyo , Atrup Atrup , Mashuri Hendra
Published: May 2022

The purpose of this study was to compare the use of ball facilities to develop soccer dribbling skills. The facilities used are standard balls and plastic balls. The method of this research is experimental with pre-test post-test group design. The research subjects were extracurricular students at SD Negeri 1 Kendal, Tulungagung, totaling 30 students. The research instrument used the Rogalski & Degel Soccer Dribbling Test. The results showed significant development of dribbling ability using standard balls and plastic balls. However, the use of plastic balls gave a better effect than the use of standard balls for elementary school-aged students.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity
Authors: Darwish Salma , Ghazy Ehab , Heimburg Tino , Herp Daniel , Zeyen Patrik , Salem-Altintas Rabia , Ridinger Johannes , Schmidtkunz Karin , Robaa Dina , Erdmann Frank , Schmidt Matthias , Romier Christophe , Jung Manfred , Oehme Ina , Sippl Wolfgang
Published: May 2022

In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated with the inhibition of cell proliferation and apoptosis enhancement in several cancer cell lines. As shown in several studies, HDAC8 can be considered a potential target in the treatment of cancer forms such as childhood neuroblastoma. The present work describes the development of proteolysis targeting chimeras (PROTACs) of HDAC8 based on substituted benzhydroxamic acids previously reported as potent and selective HDAC8 inhibitors. Within this study, we investigated the HDAC8-degrading profiles of the synthesized PROTACs and their effect on the proliferation of neuroblastoma cells. The combination of in vitro screening and cellular testing demonstrated selective HDAC8 PROTACs that show anti-neuroblastoma activity in cells. Keywords: histone deacetylases
Novel Function of CtXyn5A from Acetivibrio thermocellus: Dual Arabinoxylanase and Feruloyl Esterase Activity Occur in the Same Active Site
Authors: Schmitz Eva , Leontakianakou Savvina , Adlercreutz Patrick , Nordberg Karlsson Eva , Linares-Pastén Javier
Published: May 2022

Uncharacterized side activities of enzymes can have significant negative effects on reaction products and yields. Hence, their identification and characterization is crucial for the development of successful reaction systems. Here, we report the presence of feruloyl esterase activity in CtXyn5A from Acetivibrio thermocellus besides its well-known arabinoxylanase activity for the first time. Both reaction types appear to be catalysed in the same active site in two subsequential steps. The ferulic acid substituent is cleaved off first, followed by the hydrolysis of the xylan backbone. The esterase activity on complex carbohydrates was found to be higher than the one of a designated ferulic acid esterase (E-FAERU). Therefore, we conclude that the enzyme exhibits a dual function rather than an esterase side activity.
Photoinduced Oxygen Transfer using Nitroarenes for the Anaerobic Cleavage of Alkenes
Authors: Wise Daniel , Gogarnoiu Emma , Vacala Taylor , Paolillo Joshua , Hussain Waseem , Duke Alana , Parasram Marvin
Published: May 2022

Herein we report a visible light promoted method for the cleavage of alkenes into valuable carbonyl derivatives using economical nitroarenes as oxygen transfer reagents. This approach serves as an operationally simple and practical alternative to mainstream oxidative cleavage protocols, such as ozonolysis and the Lemieux–Johnson reaction, with comparable efficiency and without their considerable limitations. Mechanistic studies support that the transformation occurs via a solvent separated ion-pair complex and that the nitroarene undergoes direct photoexcitation to trigger a radical cycloaddition event with alkenes leading to a 1,3,2-dioxazolidine intermediate that fragments to give the desired carbonyl products. A combination of radical clock experiments and in situ PhotoNMR spectroscopy revealed the identities of the key radical species and the putative aryl 1,3,2-dioxazolidine intermediate, respectively.
Understanding the formation of polytypes, stacking faults, and grain boundaries during crystallization of FAPbI3 perovskite
Authors: Ahlawat Paramvir
Published: May 2022

Control over morphological evolution is essential to make efficient, stable and reproducible perovskite electronics. In this letter, molecular dynamics simulations are performed to understand the crystallization of polytypes, stacking faults and grain boundaries of formamidinium lead iodide.
Late-stage diversification of indole skeletons through nitrogen atom insertion
Authors: Reisenbauer Julia C. , Green Ori , Franchino Allegra , Finkelstein Patrick , Morandi Bill
Published: May 2022

Advances in the field of late-stage functionalization have expedited lead-structure discovery and established new opportunities to access valuable molecules. Although many peripheral late-stage transformations, mainly focusing on C–H functionalizations, have been reported, reliable strategies to directly edit the core skeleton of lead compounds have remained scarce. Late-stage remodeling strategies of widely encountered and pharmaceutically relevant scaffolds, such as indoles, would offer enormous potential to expand accessible chemical space. Herein, we report the skeletal editing of indoles through nitrogen atom insertion, accessing their corresponding quinazoline or quinoxaline bioisosteres via trapping of an electrophilic nitrene species generated from ammonium carbamate and hypervalent iodine. This unique reactivity is unlocked through the strategic use of a silyl group which acts as a reactivity-controlling element to suppress the inherent nucleophilicity of the nitrogen in indoles. Importantly, the utility of this highly functional group-tolerant methodology in the context of late-stage skeletal editing of several commercial drugs is demonstrated.
Artificial Neural Network Encoding of Molecular Wavefunction for Quantum Computing
Authors: Hagai Masaya , Sugiyama Mahito , Tsuda Koji , Yanai Takeshi
Published: May 2022

Artificial neural networks (ANNs) for material modeling have received significant interest. We recently reported an adaptation of ANNs based on Boltzmann machine (BM) architectures to an ansatz of the multiconfigurational many-electron wavefunction, designated neural-network quantum state (NQS), for quantum chemistry calculations. Here, this study presents its extended formalism to a quantum algorithm that enables the preparation of the NQS through quantum gates. The descriptors of the ANN model, which are chosen as occupancies of electronic configurations, are quantum-mechanically represented by qubits. Our algorithm may thus bring potential advantages over classical sampling-based computation employed in the previous studies. The NQS can be accurately formed through the quantum-native procedures, but the training of the model in terms of energy minimization is performed on a classical computer; thus, our approach is a class of variational quantum eigensolver. The BM models are related to the Gibbs distribution, and our preparation procedures exploit techniques of quantum phase estimation but with no Hamiltonian evolution. The proposed algorithm is assessed by implementing it on a quantum computer simulator. Illustrative molecular calculations at the complete-active-space configuration interaction level of theory are displayed, confirming consistency with the accuracy of our previous classical approaches.
Effect of Autonomous Police Committee on Autonomous Police Affairs Preference
Authors:   KOREA CPTED ASSOCIATION, Cho Je-seong , Kang So-young
Published: May 2022

There have been many issues since the implementation of the autonomous police system, and one of the most important issues was the issue of the police's preference for the work of the autonomous police after the implementation of the autonomous police system. The importance of the implementation of the self-governing police system is growing in terms of two key goals: democracy and citizen-centered security services. This is because the police, who perform their duties with a low preference for autonomous police work, may not only lower the quality of public security services provided to citizens, but also greatly affect the work capacity. In this study, after the implementation of the self-governing police system, the factors affecting the preference of the self-governing police were considered to be in the role of the self-governing police committee, and an empirical verification was attempted. As a result of the analysis, it is concluded that the higher the recognition of the high level of democracy and internal operation of the autonomous police committee, the more significant it is that the preference for the autonomous police work of the police increases. The model explanatory power of the assumption that the role of the autonomous police committee affects the preference of autonomous police officers is 32.3%, which has a very high model explanatory power. Therefore, it was possible to prove that the role of the autonomous police committee is a very important part in the police's preference for the autonomous police work. Based on these results, an integrated attempt to enact ordinances for organic cooperation and internal operation with the heads of local governments and local governments, and proposals for budget and work systems were attempted.