bluuebunny/crossref_metadata_2025 huggingface dataset:
PROBLEMS OF FINANCIAL DECENTRALIZATION IN UKRAINE
Authors:   National Transport University, Kyiv, Ukraine, L Kozak , T Chkalova ,   National Transport University, Kyiv, Ukraine
Published: November 2021

To date, the Ukrainian state is in the process of changing the vector of economic development and updating the governance mechanism in the context of the European integration trend, which includes supporting, adopting and approximating to European standards of economic and social development and reforming budgetary policy in the direction of strengthening the role of local budgets. This requires a new look at the concept of «development budget» within the state's budget system, which emphasizes the need to research the category «development budget» and its role in managing local finances. The object of the study is the formation of local budgets in the context of decentralization. The purpose of the study is to study the ways of socio-economic development of Ukrainian regions. The research method is the method of analysis, analogy and method of comparisons KEYWORDS: LOCAL BUDGETS, DECENTRALIZATION, EXPENDITURE, DEVELOPMENT BUDGET
CONTROLLING AS AN INSTRUMENT FOR MANUFACTURING MANAGMENT
Authors:   National Transport University, Kyiv, Ukraine, O Korolyova , T Turpak ,   National Transport University, Kyiv, Ukraine, V Hoshovska ,   National Transport University, Kyiv, Ukraine
Published: November 2021

The importance of material and financial resources rational use grows in the context of the economic crisis. In this regard, there is a need of a quality control system, which would make possible to fight mismanagement, squandering and misuse in the production sphere. This article explores the problems of production processes monitoring taking into account the technical capabilities of enterprises. The necessity of introducing the following indicators into the practical activities of production enterprises has been proved: coefficient of technical capabilities use (will allow to include in the cost of production more reasonable amount of depreciation); production capacity coefficient (will optimize the costs of maintaining and operating production equipment); coefficients of reference labor input, reference production equipment productivity, reference production intensity (expand the verification function of internal control and supplement it with the study of production costs from the position of their approximation to the standard, which are the costs of leading enterprises in the industry). The aim of introducing these indicators is to control the production process at the enterprise from the position of its compliance with the requirements of modern scientific and technological progress. The proposed innovations will improve the quality and objectivity of internal control, as well as contribute to the development of its strategic direction. Object of study - controlling system in production. The purpose of the study is to identify problematic issues of production control at domestic enterprises and develop proposals for their solution. Research methods - general scientific empirical and theoretical. The results of the article can be used by domestic manufacturing enterprises. KEY WORDS: PRODUCTION, EFFICIENCY, CONTROLLING, THE CONTROL, DEPRECIATION, COSTS, REFERENCE INDICATOR.
Development of an Autophagy-Based and Stemness-Correlated Prognostic Model for Hepatocellular Carcinoma Using Bulk and Single-Cell RNA-Sequencing
Authors: Shen Shengwei , Wang Rui , Qiu Hua , Li Chong , Wang Jinghan , Xue Junli , Tang Qinghe
Published: November 2021

Accumulating evidence has proved that autophagy serves as a tumor promoter in formed malignancies, and the autophagy-related prognostic signatures have been constructed as clinical tools to predict prognosis in many high-mortality cancers. Autophagy-related genes have participated in the development and metastasis of hepatocellular carcinoma (HCC), but the understanding of their prognostic value is limited. Thereafter, LIMMA and survival analysis were conducted in both ICGC and TCGA databases and a total of 10 hub autophagy-related genes, namely, NPC1, CDKN2A, RPTOR, SPHK1, HGS, BIRC5, SPNS1, BAK1, ATIC, and MAPK3, were collected. Then, GO, KEGG, correlation, consensus, and PCA analyses were utilized to reveal their potential targeted role in HCC treatment. Single-cell RNA-seq of cancer stem cells also indicated that there was a positive correlation between these genes and stemness. In parallel, we applied univariate, LASSO, and multivariate regression analyses to study the autophagy-related genes and finally proposed that ATIC and BIRC5 were the valuable prognostic indicators of HCC. The signature based on ATIC and BIRC5 exhibited moderate power for predicting the survival of HCC in the ICGC cohort, and its efficacy was further validated in the TCGA cohort. Taken together, we suggested that 10 aforementioned hub genes are promising therapeutic targets of HCC and the ATIC/BIRC5 prognostic signature is a practical prognostic indicator for HCC patients.
Identification of ACTA2 as a Key Contributor to Venous Malformation
Authors: Wang Song , Zhou Zifu , Li Jing , Wang Yu , Li Hongwen , Lv Renrong , Xu Guangqi , Zhang Jian , Bi Jianhai , Huo Ran
Published: November 2021

Objectives: Proteomics and high connotation functional gene screening (HCS) were used to screen key functional genes that play important roles in the pathogenesis of venous malformation. Furthermore, this study was conducted to analyze and explore their possible functions, establish a gene mutation zebrafish model, and perform a preliminary study to explore their possible pathogenic mechanisms in venous malformation.

Methods: Pathological and normal tissues from patients with disseminated venous malformation were selected for Tandem Mass Tag (TMT) proteomics analysis to identify proteins that were differentially expressed. Based on bioinformatics analysis, 20 proteins with significant differential expression were selected for HCS to find key driver genes and characterize the expression of these genes in patients with venous malformations. In vitro experiments were then performed using human microvascular endothelial cells (HMEC-1). A gene mutant zebrafish model was also constructed for in vivo experiments to explore gene functions and pathogenic mechanisms.

Results: The TMT results showed a total of 71 proteins that were differentially expressed as required, with five of them upregulated and 66 downregulated. Based on bioinformatics and proteomics results, five highly expressed genes and 15 poorly expressed genes were selected for functional screening by RNAi technology. HCS screening identified ACTA2 as the driver gene. Quantitative polymerase chain reaction (qPCR) and western blot were used to detect the expression of ACTA2 in the pathological tissues of patients with venous malformations and in control tissues, and the experimental results showed a significantly lower expression of ACTA2 in venous malformation tissues (P < 0.05). Cell assays on the human microvascular endothelial cells (HMEC-1) model showed that cell proliferation, migration, invasion, and angiogenic ability were all significantly increased in the ACTA2 over-expression group (P < 0.05), and that overexpression of ACTA2 could improve the inhibitory effect on vascular endothelial cell proliferation. We constructed an ACTA2-knockdown zebrafish model and found that the knockdown of ACTA2 resulted in defective vascular development, disruption of vascular integrity, and malformation of micro vein development in zebrafish. Further qPCR assays revealed that the knockdown of ACTA2 inhibited the Dll4/notch1 signaling pathway, Ephrin-B2 signaling pathway, and vascular integrity-related molecules and activated the Hedgehog signaling pathway.

Conclusion: This study revealed that ACTA2 deficiency is an important factor in the pathogenesis of venous malformation, resulting in the disruption of vascular integrity and malformed vascular development. ACTA2 can be used as a potential biomarker for the treatment and prognosis of venous malformations.
The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function
Authors: Rose Maddison , Bai Bond , Tang Ming , Cheong Chee Man , Beard Sam , Burgess Joshua T. , Adams Mark N. , O’Byrne Kenneth J. , Richard Derek J. , Gandhi Neha S. , Bolderson Emma
Published: November 2021

Barrier-to-Autointegration Factor 1 (Banf1/BAF) is a critical component of the nuclear envelope and is involved in the maintenance of chromatin structure and genome stability. Banf1 is a small DNA binding protein that is conserved amongst multicellular eukaryotes. Banf1 functions as a dimer, and binds non-specifically to the phosphate backbone of DNA, compacting the DNA in a looping process. The loss of Banf1 results in loss of nuclear envelope integrity and aberrant chromatin organisation. Significantly, mutations in Banf1 are associated with the severe premature ageing syndrome, Néstor–Guillermo Progeria Syndrome. Previously, rare human variants of Banf1 have been identified, however the impact of these variants on Banf1 function has not been explored. Here, using in silico modelling, biophysical and cell-based approaches, we investigate the effect of rare human variants on Banf1 structure and function. We show that these variants do not significantly alter the secondary structure of Banf1, but several single amino acid variants in the N- and C-terminus of Banf1 impact upon the DNA binding ability of Banf1, without altering Banf1 localisation or nuclear integrity. The functional characterisation of these variants provides further insight into Banf1 structure and function and may aid future studies examining the potential impact of Banf1 function on nuclear structure and human health.
Study on Unloading Relaxation Characteristics of Columnar Jointed Rock Masses Based on Displacement Back Analysis
Authors: Yu Jun , Zhang Qiang , Xu Weiya , Wang Rubin , Zhang Han
Published: November 2021

We aim to understand the relaxation of columnar joint rock masses during the excavation process of the diversion tunnel of the Baihetan hydropower station. This paper inverts the deformation parameters of the relaxed columnar joint rock based on the displacement monitoring data, and introduces a relaxation factor to describe the deterioration degree of anisotropic parameters of the relaxed columnar jointed rock. The equivalent strain is proposed as the criterion of unloading relaxation and the threshold is also given. Based on the software Flac3d, a program for calculating anisotropic elastoplastic model is developed. The distribution of the relaxation zone of the diversion tunnel after excavation is simulated, and compared with the results of the acoustic detection to verify the correctness and rationality of the program, which can provide a necessary reference for the design and construction of hydropower projects.
Combining Oxidative Torrefaction and Pyrolysis of Phragmites australis: Improvement of the Adsorption Capacity of Biochar for Tetracycline
Authors: Jiang Shilin , Tan Mengjiao , Huang Zhongliang , Hu Jinguang , Li Changzhu , Lei Tingzhou , Zhang Xuan , Wu Zijian , Huang Jing , Qin Xiaoli , Li Hui
Published: November 2021

Graphical Abstract

PAS biochar production and TC adsorption.
The Arctic Temperature Response to Global and Regional Anthropogenic Sulfate Aerosols
Authors: Asutosh Acharya , Fadnavis Suvarna , Nuncio M. , Müller Rolf , Tripathy Sarat C.
Published: November 2021

The mechanisms behind Arctic warming and associated climate changes are difficult to discern. Also, the complex local processes and feedbacks like aerosol-cloud-climate interactions are yet to be quantified. Here, using the Community Earth System Model (CAM5) experiments, with emission enhancement of anthropogenic sulfate 1) five-fold globally, 2) ten-times over Asia, and 3) ten-times over Europe we show that regional emissions of sulfate aerosols alter seasonal warming over the Arctic, i.e., colder summer and warmer winter. European emissions play a dominant role in cooling during the summer season (0.7 K), while Asian emissions dominate the warming during the winter season (maximum ∼0.6 K) in the Arctic surface. The cooling/warming is associated with a negative/positive cloud radiative forcing. During the summer season increase in low–mid level clouds, induced by sulfate emissions, favours the solar dimming effect that reduces the downwelling radiation to the surface and thus leads to surface cooling. Warmer winters are associated with enhanced high-level clouds that induce a positive radiative forcing at the top of the atmosphere. This study points to the importance of international strategies being implemented to control sulfate emissions to combat air pollution. Such strategies will also affect the Arctic cooling/warming associated with a cloud radiative forcing caused by sulfate emission change.
Indoleamine 2,3-Dioxygenase Cannot Inhibit Chlamydia trachomatis Growth in HL-60 Human Neutrophil Granulocytes
Authors: Virok Dezső P. , Tömösi Ferenc , Keller-Pintér Anikó , Szabó Kitti , Bogdanov Anita , Poliska Szilárd , Rázga Zsolt , Bruszel Bella , Cseh Zsuzsanna , Kókai Dávid , Paróczai Dóra , Endrész Valéria , Janáky Tamás , Burián Katalin
Published: November 2021

Aims

Neutrophil granulocytes are the major cells involved in Chlamydia trachomatis (C. trachomatis)-mediated inflammation and histopathology. A key protein in human intracellular antichlamydial defense is the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) which limits the growth of the tryptophan auxotroph Chlamydia. Despite its importance, the role of IDO in the intracellular defense against Chlamydia in neutrophils is not well characterized.

Methods

Global gene expression screen was used to evaluate the effect of C. trachomatis serovar D infection on the transcriptome of human neutrophil granulocytes. Tryptophan metabolite concentrations in the Chlamydia-infected and/or interferon-gamma (IFNG)-treated neutrophils were measured by ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS).

Results

Our results indicate that the C. trachomatis infection had a major impact on neutrophil gene expression, inducing 1,295 genes and repressing 1,510 genes. A bioinformatics analysis revealed that important factors involved in the induction of neutrophil gene expression were the interferon-related transcription factors such as IRF1-5, IRF7-9, STAT2, ICSB, and ISGF3. One of the upregulated genes was ido1, a known infection- and interferon-induced host gene. The tryptophan-degrading activity of IDO1 was not induced significantly by Chlamydia infection alone, but the addition of IFNG greatly increased its activity. Despite the significant IDO activity in IFNG-treated cells, C. trachomatis growth was not affected by IFNG. This result was in contrast to what we observed in HeLa human cervical epithelial cells, where the IFNG-mediated inhibition of C. trachomatis growth was significant and the IFNG-induced IDO activity correlated with growth inhibition.

Conclusions

IDO activity was not able to inhibit chlamydial growth in human neutrophils. Whether the IDO activity was not high enough for inhibition or other chlamydial growth-promoting host mechanisms were induced in the infected and interferon-treated neutrophils needs to be further investigated.
Effects of Flow Velocity on the Growth and Survival of Haliotis discus hannai Larvae in the Recirculating Upflow System From the Point of Energy Metabolism
Authors: Zhang Mo , Gao Xiaolong , Lyu Mingxin , Lin Shihui , Su Ying , Luo Xuan , You Weiwei , Ke Caihuan
Published: November 2021

For the abalone Haliotis discus hannai, attachment and metamorphosis are crucial stages in the transition from planktonic to benthic life. Increasing the larval metamorphosis rate by artificially controlling the external environment and simulating natural seawater flow is vital to enhance the hatchery efficiency of H. discus hannai. Thus, in the current study, an upflow recirculating aquaculture unit was designed for the rearing of larval abalone, and the larval hatching rate, survival rate, mode of energy metabolism, and expression levels of metamorphosis-related genes at different flow velocities (0, 5, 10, 20, and 40 L/h) were compared and analyzed. At flow velocities less than 20 L/h, no significant differences occurred in larval hatching, survival, and metamorphosis rates, whereas significant differences were recorded at flow rates of 20 and 40 L/h. Differences were also observed in the activity of enzymes, such as hexokinase (HK), pyruvate kinase (PK), lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH), as well as glycogen levels, at the higher flow rates. These results suggested that velocity in excess of a certain limit leads to a higher glycolysis rate and transition of energy utilization from aerobic to anaerobic metabolism for the abalone larvae. Compared with conventional still-water aquacultural systems, the flow velocity at 5–10 L/h could maintain the water environment stability, and avoid both fertilized eggs from being densely deposited before hatching and the consumption of energy needed to resist high flow velocities. Thus, these results are useful references to enhance the hatchery efficiency, and to conduct large-scale rearing, of abalone larvae.
The Non-stationary Environmental Effects on Spawning Habitat of Fish in Estuaries: A Case Study of Coilia mystus in the Yangtze Estuary
Authors: Wang Dong , Wan Rong , Li Zengguang , Zhang Junbo , Long Xiangyu , Song Pengbo , Zhai Lu , Zhang Shuo
Published: November 2021

The estuarine areas provide necessary spawning habitat, nursing habitat, and migratory for a variety of fishes and the environmental conditions are of significant heterogeneity.Coilia mystusis the key commercial fish that spawns in the Yangtze Estuary and the yield has declined sharply in the past 30 years. In order to understand the spawning habitat selection mechanism ofC. mystus, the geographically weighted regression (GWR) model was applied to explore the non-stationary effect of environmental variables [e.g., the sea surface temperature (SST) and the sea surface salinity (SSS)] and geographical variables [e.g., the distance to the coast (DTC) and the depth (DEP) of water] on the egg density distribution ofC. mystus. The data were derived from the spring and summer ichthyoplankton surveys carried out from 2019 to 2020 in the Yangtze Estuary, China. The GWR model results showed that the key variables in different seasons had spatial non-stationary effects on the distribution of spawning habitat ofC. mystus, which were mainly caused by regional rise in temperature and saltwater intrusion of the South Branch. In the spring, the SSS, the DTC, and the DEP were the main impact factors and saltwater intrusion in the South Branch might lead to the trend that the spawning habitat moved further upstream to the Changxing Island. The SST was most important in the summer and the relatively lower SST was more crucial in the spawning habitat selection than the DTC and the DEP. The GWR model performed well in the study ofC. mystuspotential spawning habitat in the Yangtze Estuary. We recommend that more attention should be paid in regional variation of environmental factors to explore fish potential spawning habitat in the estuarine areas.
Optimization of Preparation of Foamed Concrete Based on Orthogonal Experiment and Range Analysis
Authors: Cong Menglong , Zhang Shanshan , Sun Dandan , Zhou Kunpeng
Published: November 2021

For the purpose of reducing the energy consumption and construction cost of buildings, the preparation process of geopolymer based foamed concrete, which is a novel material of the wall and roof of building, had been studied in detail. Water glass and sodium hydroxide were used as the alkali activator to excite the mixture consists of slag, fly ash and Kaolin to form the geopolymer matrix, and finally the foams generated using the physical foaming method were filled into the geopolymer matrix to produce geopolymer-based foamed concrete blocks. In the preparation process, firstly one of the four parameters of foam content, water-binder ratio, water glass content, and water glass modulus had been changed separately to study the influence of a single factor on the compressive strength, dry density, thermal conductivity and specific strength of foamed concrete blocks. The experimental results show that the above four factors have different degrees of influence on the concerned performances. Next, some representative combinations of these factors were constructed by orthogonal experiment method, and the influence degree of each combination on the concerned performances was determined by means of range analysis. According to the results of analysis, the most important influencing factor in terms of thermal conductivity was the water-binder ratio, followed by foam content, water glass modulus and water glass content. When the foam content is 1.58%, the water-binder ratio is 0.45, the water glass content is 30%, and the water glass modulus is 1.2, the thermal conductivity of the prepared geopolymer foam concrete reaches 0.044 W/(m·K), which satisfies the expected requirements for heating in severe cold areas.
Pre-Consultation System Based on the Artificial Intelligence Has a Better Diagnostic Performance Than the Physicians in the Outpatient Department of Pediatrics
Authors: Qian Han , Dong Bin , Yuan Jia-jun , Yin Fan , Wang Zhao , Wang Hai-ning , Wang Han-song , Tian Dan , Li Wei-hua , Zhang Bin , Zhao Lie-bin , Ning Bo-tao
Published: November 2021

Artificial intelligence (AI) has been deeply applied in the medical field and has shown broad application prospects. Pre-consultation system is an important supplement to the traditional face-to-face consultation. The combination of the AI and the pre-consultation system can help to raise the efficiency of the clinical work. However, it is still challenging for the AI to analyze and process the complicated electronic health record (EHR) data. Our pre-consultation system uses an automated natural language processing (NLP) system to communicate with the patients through the mobile terminals, applying the deep learning (DL) techniques to extract the symptomatic information, and finally outputs the structured electronic medical records. From November 2019 to May 2020, a total of 2,648 pediatric patients used our model to provide their medical history and get the primary diagnosis before visiting the physicians in the outpatient department of the Shanghai Children's Medical Center. Our task is to evaluate the ability of the AI and doctors to obtain the primary diagnosis and to analyze the effect of the consistency between the medical history described by our model and the physicians on the diagnostic performance. The results showed that if we do not consider whether the medical history recorded by the AI and doctors was consistent or not, our model performed worse compared to the physicians and had a lower average F1 score (0.825 vs. 0.912). However, when the chief complaint or the history of present illness described by the AI and doctors was consistent, our model had a higher average F1 score and was closer to the doctors. Finally, when the AI had the same diagnostic conditions with doctors, our model achieved a higher average F1 score (0.931) compared to the physicians (0.92). This study demonstrated that our model could obtain a more structured medical history and had a good diagnostic logic, which would help to improve the diagnostic accuracy of the outpatient doctors and reduce the misdiagnosis and missed diagnosis. But, our model still needs a good deal of training to obtain more accurate symptomatic information.
Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
Authors: Tong Ling , Yan Cuilin , Wang Minjie , Yang Jiajia , Wang Hongmei , Wang Ying
Published: November 2021

Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.

Methods: We collected serum samples from 100 patients with chronic hepatitis B (CHB) and from 114 HBV-LC patients to test serum exosomal AHCY expression using ELISA.

Results: Compared with the CHB and Grade A and B HBV-LC groups, the level of exosomal AHCY expression was significantly higher in the HBV-LC group [376.62 (291.50–448.02) vs. 248.12 (189.28–324.63), P > 0.001] and the Grade C HBV-LC group [408.70 (365.63–465.76) vs. 279.76 (215.16–336.07), P > 0.001], respectively. Serum exosomal AHCY expression and MELD score had a significant positive correlation (r = 0.844, P < 0.001). Survival curve analysis showed that patients with low exosomal AHCY expression had significantly longer survival than patients with high exosomal AHCY expression (P = 0.0038). The receiver operating characteristics (ROC) curve showed that the area under the curve (AUC) value for the mortality prediction ability of serum exosomal AHCY in HBV-LC patients was 0.921, which was higher than the values for the MELD score (AUC 0.815) and Child-Pugh classification (AUC 0.832), with a sensitivity and specificity of 93.41 and 76.00%, respectively.

Conclusions: The serum exosomal AHCY level is a novel potential prognostic biomarker in HBV-LC patients, which may be great significance for the prognosis of HBV-LC patients.
Effects of Mixing Garlic Skin on Fermentation Quality, Microbial Community of High-Moisture Pennisetum hydridum Silage
Authors: Chen Juncai , Huang Guohao , Xiong Hanlin , Qin Hao , Zhang Haonan , Sun Yawang , Dong Xianwen , Lei Yan , Zhao Yongju , Zhao Zhongquan
Published: November 2021

Garlic skin, a by-product of garlic processing, was supposed to improve the fermentation quality of high-moisture silages because of its low moisture content and active compounds. Thus, fermentation and microbial characteristics of high-moisture Pennisetum hydridum ensiled with the addition of 0, 10, 20, and 30 wt% garlic skin (on a fresh matter basis) were analyzed during a 60-days fermentation. Results showed that the addition of garlic skin increased the dry matter content and lactic acid production, and decreased the pH and ammonia-N content of the silage. Adding garlic skin changed the relative abundance of bacterial communities with an increase in Lactobacillus and a decrease in Clostridium relative abundance. In conclusion, co-ensiling of high-moisture Pennisetum hydridum with garlic skin could be a simple approach to improve the silage quality and nutrients preservation.
On the Relationship Between EB-3 Profiles and Microtubules Growth in Cultured Cells
Authors: Urazbaev Arshat , Serikbaeva Anara , Tvorogova Anna , Dusenbayev Azamat , Kauanova Sholpan , Vorobjev Ivan
Published: November 2021

Microtubules are dynamic structures undergoing rapid growth and shrinkage in living cells and in vitro. The growth of microtubules in vitro was analyzed with subpixel precision (Maurer et al., Current Biology, 2014, 24 (4), 372–384); however, to what extent these results could be applied for microtubules growing in vivo remains largely unknown. Particularly, the question is whether microtubule growth velocity in cells could be sufficiently approximated by a Gaussian distribution or its variability requires a more sophisticated description? Addressing this question, we used time-lapse microscopy and mathematical modeling, and we analyzed EB-3 comets forming on microtubules of cultured cells with subpixel precision. Parameters of comets (shape, form, and velocity) were used as topological characteristics of 3D voxel objects. Using regression analysis, we determined the real positions of the microtubule tips in time-lapse sequences. By exponential decay fitting of the restored comet intensity profile, we found that in vivo EB-3 rapidly exchanges on growing microtubule ends with a decoration time ∼ 2 s. We next developed the model showing that the best correlation between comet length and microtubule end growth velocity is at time intervals close to the decoration time. In the cells, EB comet length positively correlates with microtubule growth velocity in preceding time intervals, while demonstrating no correlation in subsequent time intervals. Correlation between comet length and instantaneous growth velocity of microtubules remains under nocodazole treatment when mean values of both parameters decrease. Our data show that the growth of microtubules in living cells is well-approximated by a constant velocity with large stochastic fluctuations.
Sintilimab and Chidamide for Refractory Transformed Diffuse Large B Cell Lymphoma: A Case Report and A Literature Review
Authors: Chen Chao , Zhang Wei , Zhou Daobin , Zhang Yan
Published: November 2021

Patients with relapsed/refractory (R/R) transformed diffused large B cell lymphoma (tDLBCL) have a poor prognosis and a low survival rate. In addition, no standard therapy has yet been established for R/R tDLBCL. Herein we presented a single case of a patient with R/R tDLBCL who was successfully treated with sintilimab and chidamide. The patient was a 71-year-old man with pulmonary mucosa-associated lymphoid tissue lymphoma. He did not receive any treatment until tDLBCL was confirmed 2 years later. The tDLBCL was primary refractory to R2-CHOP, R2-MTX, and Gemox regimens. However, the patient achieved sustained complete remission after the combination therapy of sintilimab and chidamide. To the best of our knowledge, this is the first report of sintilimab combined with chidamide for the treatment of R/R tDLBCL, which opens up new therapeutic possibilities for this new combination therapy in future prospective clinical trials.
An Investigation of the Risk Factors Associated With Anti-Tuberculosis Drug-Induced Liver Injury or Abnormal Liver Functioning in 757 Patients With Pulmonary Tuberculosis
Authors: Zhong Tao , Fan Yuzheng , Dong Xiao-Li , Guo Xujun , Wong Ka Hing , Wong Wing-tak , He Daihai , Liu Shengyuan
Published: November 2021

Objectives: To identify the risk factors associated with anti-tuberculosis drug-induced liver injury (AT-DILI) or abnormal living functioning from 757 patients with pulmonary tuberculosis (TB) registered at Nanshan Center for Chronic Disease Control (Nanshan CCDC), Shenzhen, Guangdong Province, China.

Design and methods: We identified 757 TB patients who met our inclusion criteria by screening the Hospital Information System (HIS) at Nanshan CCDC. Next, we identified positive cases of AT-DILI or abnormal liver functioning based on results of the first-time liver function tests (LFTs) after taking anti-TB drugs. The χ2 test was used to relate the positive rate with a variety of factors. A logistic regression model was also used to identify statistically significant risk factors.

Results: Of the 757 patients, the positive rate of AT-DILI or abnormal liver functioning was 37.9% (287/757). Univariate analysis revealed that the positive rate was 42.91% (212/494) for males and 28.52% (75/263) for females. The positive rate was significantly higher in males (p <0.001). Patients with an annual income of 9,231–13,845 USD had a significantly higher positive rate (67.35%; 33/49) than those with an income of 1,540–4616 USD (37.97%; 30/79) (p = 0.022). The most frequent prescription regime among positive cases was a 2 months supply of fixed dose combination Ethambutol Hydrochloride, Pyrazinamide, Rifampicin and Isoniazid Tablets (Ⅱ) 450 mg) followed by a 4 months supply of fixed dose combination Rifampin and Isoniazid Capsules (2FDC-HRZE half/4FDC-HR) at 56.03% (144/257). The least frequent prescription regime was a 2 months supply of fixed dose combination Rifampin, Isoniazid and Pyrazinamide Capsules with Ethambutol independently followed by a 4 months supply of fixed dose combination Rifampin and Isoniazid Capsules (2FDC-HRZ + EMB/4FDC-HR) at 24.27% (25/103). The difference between these two different regimes was significant (p = 0.022). With an increase in the duration of medication, patients under various prescription regimes all showed a gradual increase in the positive rate of AT-DILI or abnormal liver functioning.

Conclusion: We identified several risk factors for the occurrence of AT-DILI or abnormal liver functioning, including gender, annual income, prescription regime, dosage, and treatment time.
Risk Factors, Incidence, and Prognosis of Thromboembolism in Cancer Patients Treated With Immune Checkpoint Inhibitors
Authors: Zou Xue-lin , Chen Wei-yong , Zhang Guang-yan , Ke Hua , Yang Qiu-hong , Li Xiao-bo
Published: November 2021

In recent years, immune checkpoint inhibitors (ICIs) have become the standard treatment option for tumors. With the widespread application of ICIs, immune-related adverse events (irAEs) have gradually attracted the attention of researchers. Owing to the characteristics of ICIs, irAEs can affect each organ of the human body. Thromboembolism is uncommon in cancer patients receiving ICIs, but it may affect their survival. Most thromboembolic events do not cause serious effects after early prediction and treatment, but life-threatening toxic reactions are also observed. This condition should not be ignored because of vague and atypical symptoms, which make early diagnosis more challenging. This article focuses on the high-risk factors, underlying mechanisms, incidence, and prognosis of thromboembolism in patients using ICIs and briefly describes the intervention and treatment measures. This information would allow patients to effectively manage the side effects of thromboembolism during Immune checkpoint inhibitors treatment, ensuring the efficacy of ICIs and reducing mortality.
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme
Authors: Tsai Tai-Hsin , Lieu Ann-Shung , Huang Tzuu-Yuan , Kwan Aij-Lie , Lin Chih-Lung , Hsu Yi-Chiang
Published: November 2021

Background: Glioblastoma multiforme (GBM) is the vicious malignant brain tumor in adults. Despite advances multi-disciplinary treatment, GBM constinues to have a poor overall survival. CDDO-trifluoroethyl-amide (CDDO-TEFA), a trifluoroethylamidederivative of CDDO, is an Nrf2/ARE pathway activator. CDDO-TEFEA is used to inhibit proliferation and induce apoptosis in glioma cells. However, it not clear what effect it may have on tumorigenesis in GBM.

Methods: This in vitro study evaluated the effects of CDDO-TFEA on GBM cells. To do this, we treated GBM8401 cell lines with CDDO-TFEA and assessed apoptosis, cell cycle. DNA content and induction of apoptosis were analyzed by flow cytometry and protein expression by Western blot analysis.

Results: CDDO-TFEA significantly inhibited the cell viability and induced cell apoptosis on GBM 8401 cell line. The annexin-FITC/PI assay revealed significant changes in the percentage of apoptotic cells. Treatment with CDDO-TFEA led to a significant reduction in the GBM8401 cells’ mitochondrial membrane potential. A significant rise in the percentage of caspase-3 activity was detected in the treated cells. In addition, treatment with CDDO-TFEA led to an accumulation of G2/M-phase cells. In addition, these results suggest that regarding increased protein synthesis during mitosis in the MPM-2 staining, indicative of a delay in the G2 checkpoint. An analysis of Cyclin B1, CDK1, Cyclin B1/CDK1 complex and CHK1 and CHK2 expression suggested that cell cycle progression seems also to be regulated by CDDO-TFEA. Therefore, CDDO-TFEA may not only induce cell cycle G2/M arrest, it may also exert apoptosis in established GBM cells.

Conclusion: CDDO-TFEA can inhibit proliferation, cell cycle progression and induce apoptosis in GBM cells in vitro, possibly though its inhibition of Cyclin B1, CDK1 expression, and Cyclin B1/CDK1 association and the promotion of CHK1 and CHK2 expression.
Socioeconomic Determinants of Diet Quality on Overweight and Obesity in Adults Aged 40–59 Years in Inner Mongolia: A Cross-Sectional Study
Authors: Su Yuenan , Du Sha , Yang Min , Wu Jing , Lu Haiwen , Wang Xuemei
Published: November 2021

Objectives: This study investigated the relationship of socioeconomic status (SES), diet quality and overweight and obesity in adults aged 40–59 years in Inner Mongolia.

Methods: This cross-sectional study was based on the survey of Chronic Disease and Nutrition Monitoring in Adults in Inner Mongolia in 2015. Diet quality was evaluated by the Alternate Mediterranean Diet score (aMeds). SES was measured by household annual income. Generalized estimating equations and path analysis were performed to determine the association of SES, diet quality and overweight and obesity.

Results: Among participants, 63.0% had overweight and obesity. In high SES group, 66.4% had overweight and obesity. Higher SES was associated with a higher risk of overweight and obesity (OR = 1.352, 95%CI: 1.020–1.793). And higher aMeds was associated with a lower risk of overweight and obesity (OR = 0.597, 95%CI: 0.419–0.851). There was a positive correlation between SES and the intake of red and processed meat (r = 0.132, p < 0.05). Higher intake of red and processed meat was associated with lower diet quality (β = −0.34). And lower diet quality was associated with a higher risk of overweight and obesity (β = −0.10).

Conclusion: In Inner Mongolia, during the period of economic transition, people aged 40–59 years in high SES had poor diet quality, which was related to a higher risk of overweight and obesity.
Current Analytical Strategies in Studying Chromatin-Associated-Proteome (Chromatome)
Authors: Khan Niamat , Shahid Sidra , Asif Abdul R.
Published: November 2021

Chromatin is a dynamic structure comprising of DNA and proteins. Its unique nature not only help to pack the DNA tightly within the cell but also is pivotal in regulating gene expression DNA replication. Furthermore it also protects the DNA from being damaged. Various proteins are involved in making a specific complex within a chromatin and the knowledge about these interacting partners is helpful to enhance our understanding about the pathophysiology of various chromatin associated diseases. Moreover, it could also help us to identify new drug targets and design more effective remedies. Due to the existence of chromatin in different forms under various physiological conditions it is hard to develop a single strategy to study chromatin associated proteins under all conditions. In our current review, we tried to provide an overview and comparative analysis of the strategies currently adopted to capture the DNA bounded protein complexes and their mass spectrometric identification and quantification. Precise information about the protein partners and their function in the DNA-protein complexes is crucial to design new and more effective therapeutic molecules against chromatin associated diseases.
Detection and Location of Model-Plant Mismatch in Multiple Input Multiple Output Systems under Model Predictive Controller Using Granger Causality Method
Authors: Chen Ming , Xie Lei , Su Hongye
Published: November 2021

In closed-loop control systems, the model accuracy exerts large influences on the controllability, stability and quality of the whole process. Among all the faults that could affect the system performance, Model Plant Mismatch (MPM) is the one that not only directly threatens the system stability but also deteriorates the controller performance. Meanwhile, MPM has a major influence on the qualities of outputs about industrial products. In this work, a new detection method based on Granger Causality is proposed to detect and locate the MPM in multiple input multiple output systems. Causality can reflect the relations between the mismatch fault and its negative effects on model predictive control(MPC) systems. With the assistance of disturbance transfer function models, the causality method can further be used to locate the mismatch positions and get the correct channels of each kind of mismatches. The proposed method was examined and validated in the Wood-Berry process in contrast to the decussation location method under model predictive controller.
The Well Posedness for Nonhomogeneous Boussinesq Equations
Authors: Liu Yan , Ouyang Baiping
Published: November 2021

This paper is devoted to studying the Cauchy problem for non-homogeneous Boussinesq equations. We built the results on the critical Besov spaces (θ,u)∈LT∞(B˙p,1N/p)×LT∞(B˙p,1N/p−1)⋂LT1(B˙p,1N/p+1) with 1<p<2N. We proved the global existence of the solution when the initial velocity is small with respect to the viscosity, as well as the initial temperature approaches a positive constant. Furthermore, we proved the uniqueness for 1<p≤N. Our results can been seen as a version of symmetry in Besov space for the Boussinesq equations.
Predator–Prey Model Based Asymmetry Resource Allocation in Satellite–Terrestrial Network
Authors: Li Zhipeng , Li Meng , Wang Qian
Published: November 2021

In the traditional satellite networks, network resources are mainly allocated among all the satellites based on the same allocation algorithm. This kind of symmetry model limits the increase of throughput. In this paper, we study an asymmetry resource allocation method in a satellite–terrestrial network and propose a Lotka–Volterra based predator–prey model to achieve optimal resource allocation among different satellites. In the proposed satellite–terrestrial network, we divide all the satellites into two groups, and we try to achieve load stability between these two satellites groups. Using the predator–prey model, one group is the prey–satellites, which can obtain service requirements from mobile users. The other group is considered as predator–satellites, which can only obtain the loads from the group of the prey–satellites. Once the satellites are divided into two groups using the Lotka–Volterra model, the resource allocation problem among these satellites in two groups would be asymmetry resource. We prove the existence of solutions to the proposed model. Numerical simulation results are given to show the correctness and effectiveness of the proposed model.
Prevalensi dan faktor resiko sangkaan rinitis alergi pada mahasiswa Fakultas Kedokteran Universitas Prima Indonesia
Authors: Sihotang Widya Yanti , Silalahi Marlinang Isabella , Sinurat Buenita , Dina Sarah , Ongko Nicolas Xavier , Diana Leni , Widyaningsih Widyaningsih
Published: November 2021

Rinitis alergi merupakan gangguan fungsi hidung yang terjadi setelah paparan alergen melalui peradangan mukosa hidung diperantarai IgE dengan gejala khas bersin, hidung tersumbat, dan ingus yang encer. Penelitian ini bertujuan untuk mencari prevalensi dan faktor risiko terjadinya rinitis alergi. Prevalensi pada usia produktif termasuk pada mahasiswa meningkat yang mengakibatkan penurunan kualitas hidup baik fisik, emosional, gangguan bekerja dan sekolah. Penelitian ini bertujuan untuk menganalisis prevalensi rinitis alergi dan berbagai faktor risiko yang berpengaruh terhadap kejadian rinitis alergi. Penelitian ini menggunakan desain cross-sectional. Subyek penelitian terdiri dari 450 mahasiswa dari Fakultas Kedokteran Universitas Prima Indonesia dan data dikumpulkan dengan menggunakan kuesioner ISAAC yang dianalisis dengan analisis bivariat menggunakan uji Chi square. Hasil penelitian menunjukkan prevalensi rinitis alergi sebesar 34.7% serta merokok (p = 0.021; RP = 2.536; 95% CI 1.123-5.730), riwayat alergi di keluarga (p=0.000; RP=7.000; 95% CI 4.447-11.018), sebagai faktor risiko terjadinya rinitis alergi. Kontak dengan tanaman (p=0.096 dan RP=0.633; CI 95 % 0.368 – 1.088), memelihara binatang piaraan (p=0.741), tempat tinggal yang berdebu dan kotor (p=0.733), jenis kelamin (p=0.428) tidak memiliki pengaruh yang bermakna terhadap kejadian rinitis alergi. Hasil penelitian ini menjadi indikasi bahwa paparan merokok dan riwayat alergi berpengaruh terhadap sangkaan rinitis alergi sehingga perlu pencegahan terhadap faktor pencetus guna peningkatan derajat kesehatan.
Mutu pelayanan dan minat kunjungan ulang pasien rawat jalan di Rumah Sakit X
Authors: Ginting Tarianna , Chairul Muhammad , Pane Putri Yunita , Sudarsono Sudarsono , Renaldi Muhammad Rizal , Lubis Fatma Hani
Published: November 2021

Pelayanan yang diselenggarakan oleh rumah sakit berkaitan langsung dengan kepuasan atau ketidakpuasan pasien. Penelitian ini bertujuan untuk mengetahui pengaruh persepsi tentang mutu pelayanan dengan minat kunjungan ulang pasien rawat jalan. Jenis penelitian yang digunakan dalam penelitian ini adalah jenis survei kuantitatif, dengan menggunakan pendekatan cross-sectional. Penelitian dilaksanakan di Rumah Sakit X yang dimulai dari bulan Juni-Juli tahun 2021. Sampel dalam penelitian ini adalah pasien yang menjalani rawat jalan sebanyak 95 orang. Metode analisis data menggunakan analisis regresi logistik. Hasil analisis menunjukkan bahwa variabel persepsi kehandalan (p=0,001), daya tanggap (p=0,028), jaminan (0,005) dan bukti fisik (0,021) berpengaruh terhadap minat kunjungan ulang pasien rawat jalan. Penelitian ini menyimpulkan bahwa kehandalan, daya tanggap, jaminan dan bukti fisik mempengaruhi minat kunjungan ulang pasien rawat jalan.
New Species of Anthurium (Araceae) from Venezuela
Authors: Croat Thomas B. , Hanson Maya
Published: November 2021

A total of nine species of Anthurium Schott sect. Calomystrium Schott (Araceae) from Venezuela are treated. Most of the species have been confused with A. cartilagineum (Desf.) Kunth; a dichotomous key to distinguish them is provided. All but one of these species are endemic to the Cordillera de la Costa in northern Venezuela. Seven species are described as new: A. alfcardozoi Croat, A. coltovarense Croat, A. galipanense Croat, A. georgetatei Croat, A. guaicaipurense Croat & M. Hanson, A. hansonianum Croat, and A. ronliesneri Croat. One additional species, Anthurium species #1, is included in the key and is fully described but is not being formally published owing to inadequate material. In addition, A. cartilagineum (Desf.) Kunth is redescribed, and a more complete description is provided since it is a close relative to several of the species treated here.
К тензорному анализу решения задачи реализации билинейной системы второго порядка с опозданием
Authors: Лакеев Анатолий Валентинович , Русанов Вячеслав Анатолиевич , Банщиков Андрей Валентинович
Published: November 2021

Определены аналитические условия (необходимые/достаточные) решения задачи дифференциальной реализации континуального пучка управляемых траекторных кривых в классе билинейных неавтономных обычных дифференциальных уравнений (с опозданием и без) второго порядка в материальном сепарабельном гильбертовом пространстве. Эта задача относится к типу обратных задач для аддитивной комбинации нестационарных линейных и билинейных операторов эволюционных уравнений в бесконечномерном гильбертовом пространстве. Метамовой данной теории служат конструкции тензорных произведений гильбертовых пространств, структуры решеток с ортодополнением и функциональный аппарат нелинейного оператора Релея-Ритца. При этом показано, что при конечном пучке траекторий наличие свойств типа сублинейности данного оператора позволяет получить достаточные условия для существования таких реализаций. Попутно обосновываются тополого-метрические условия непрерывности проектизации нелинейного функционального опера-тора Релея–Ритца с вычислением фундаментальной группы его образа. Полученные результаты побуждают к развитию теории нелинейной структурной идентификации полилинейных дифференциальных моделей высших порядков (например, для моделирования многоканальных нейроимплантов типа Neuralink).
COVID Lockdown – A boon or a bane for Researchers
Authors:   Associate Professor, Department of Commerce, Naipunnya Institute of Management and Information Technology, Thrissur-680308, Kerala, Alex Anitha Mary
Published: November 2021

The paper is to bring into light the major advantages that the researchers have got as a part of the COVID-19 Lockdown and also the demerits of the same. It talks about the experiences that many of the researchers had faced during the pandemic. This paper has tried to bring in the varied ways by which the researchers had tackled the pandemic lockdown. They could make use of the time in a very fruitful manner. The researchers were also getting a lot of opportunities to increase their critical thinking and innovative thinking in the area of research.