bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
Authors: Silva Cascales Helena , Burdova Kamila , Middleton Anna , Kuzin Vladislav , Müllers Erik , Stoy Henriette , Baranello Laura , Macurek Libor , Lindqvist Arne
Published: January 2021

Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2 phase, but why active Cyclin A2-CDK2 during the S phase does not trigger mitotic kinase activation remains unclear. Here, we describe a change in localisation of Cyclin A2 from being only nuclear to both nuclear and cytoplasmic at the S/G2 border. We find that Cyclin A2-CDK2 can activate the mitotic kinase PLK1 through phosphorylation of Bora, and that only cytoplasmic Cyclin A2 interacts with Bora and PLK1. Expression of predominately cytoplasmic Cyclin A2 or phospho-mimicking PLK1 T210D can partially rescue a G2 arrest caused by Cyclin A2 depletion. Cytoplasmic presence of Cyclin A2 is restricted by p21, in particular after DNA damage. Cyclin A2 chromatin association during DNA replication and additional mechanisms contribute to Cyclin A2 localisation change in the G2 phase. We find no evidence that such mechanisms involve G2 feedback loops and suggest that cytoplasmic appearance of Cyclin A2 at the S/G2 transition functions as a trigger for mitotic kinase activation.
FAKTOR-FAKTOR PENINGKAT MINAT BELI PELANGGAN ELEVENIA DI KOTA SEMARANG
Authors: Bakhtiar M. Rifki , Sunarka Puji Setya
Published: January 2021

Fokus dari penelitian ini adalah menganalisis keamanan, kepercayaan, harga, kualitas pelayanan pada minat beli pelanggan di kota Semarang pada situs penjualan online di Elevenia. Penentuan sampel dalam penelitian ini menggunakan metode purposive sampling. Kuisioner 100 responden yang memenuhi syarat sebagai sampel. Alat analisis data yang digunakan berupa regresi linier berganda dengan program SPSS versi 23. Berdasarkan hasil analisis dan pembahasan pada penelitian ini diperoleh hasil regresi Y= -1,862 + 0,468 X1 + 0,547 X2 + 0,171 X3 + 0,388 X4 +. Hasil penelitian menunjukkan bahwa: keamanan (X1), Kepercayaan (X2), Harga (X3), dan kualitas pelayanan (X4) berpengaruh positif dan signifikan terhadap Minat Beli. Studi itu memberikan bukti empiris bagi para marketplace meningkatkan keamanan, kepercayaan, harga, kualitas pelayanan.

 

Kata Kunci: keamanan, kepercayaan, harga, kualitas pelayanan, minat beli
Molluscicidal activity of Ipomoea batatas leaf extracts against Pomacea canaliculata (Golden apple snail)
Authors: A.A. Noorshilawati , A. Nur Suraya , S. Siti Rossiyah
Published: January 2021

This study was conducted to investigate the molluscicidal activity of four different
Ipomoea batatas (I. batatas) leaf extracts (hexane, chloroform, methanol, and aqueous
extracts) against Pomacea canaliculata (P. canaliculata) and screen the phytochemical
compounds of I. batatas leaf extracts. The golden apple snails (size range: 20–40 mm)
were exposed to three concentrations (1000, 5000, and 10,000 ppm) of each extract
(hexane, chloroform, methanol, and aqueous extracts). The efficacy of the I. batatas
extracts was laboratory-tested by submerging the P. canaliculata into paddy-filled water
mixed with the extracts and the mortality was observed every 24 hrs for 3 days. The
presence of phytochemical compounds such as terpenoids, flavonoids, saponins, tannins,
alkaloids, and glycosides were tested. For all extracts, the results showed a positive
relationship between the concentration and the golden apple snail mortality, suggesting
that all extracts have molluscicidal properties. The study showed more than 50% mortality
rate of P. canaliculata after 72 hrs for each treatment. Chloroform and methanol I. batatas
leaf extracts at 10,000 ppm showed 100% mortality after 72 hrs due to the presence of
saponin. Saponin causes the death of the snails by disturbing their feeding and growth and
blocking their breathing process. For further research, it is suggested to conduct the study
under field trials in the search for a natural and environment-friendly molluscicide.
Effect of different pasteurisation temperature on physicochemical properties, bioactive compounds, antioxidant activity and microbiological qualities of reconstituted pomegranate juice (RPJ)
Authors: Kong T.Y. , Hasnan N.Z.N. , A. Nur Diyana , I.M. Nurin-Zulkifli , Basha R.K. , Abdul Ghani N.H. , Aziz N.A.
Published: January 2021

Reconstituted pomegranate juice (RPJ) was thermally treated with high-temperature
pasteurisation (HTP) at 95°C and mild-temperature pasteurisation (MTP) at 80°C for 30 s
respectively. As a comparison, the effect on physicochemical properties, including
antioxidant activities and microbial inactivation was eavluated. Both MTP and HTP
showed effective inactivation of microbial growth to negligible level with MTP taking
almost half pasteurisation-time (-46.3%) as compared to HTP, indicating possible less
energy usage. MTP and HTP treatment delivered insignificant difference in pH, titratable
acidity, total soluble solids and colour changes (ΔE) based on Commission Internationale
de l’Elcairage (CIE) colour system. A significantly higher CIE a values and reduction in L
and b were obtained for MTP-juice indicating an increase in red tonalities due to increase
in anthocyanin contents. As for antioxidant activity and extractability of bioactive
compound, interestingly HTP delivered better results due to more phenols and
anthocyanin were released during the heating, leading to further release of initially
membrane‐bound phenols. These findings suggested that both HTP and MTP are able to
meet the microbiological safety and comparable physicochemical qualities. Nonetheless,
HTP has shown higher functional values due to higher extractability of antioxidant
compounds.
Technology Matters: SPARX – computerised cognitive behavioural therapy for adolescent depression in a game format
Authors: Fleming Theresa , Lucassen Mathijs , Stasiak Karolina , Sutcliffe Kylie , Merry Sally
Published: January 2021

No description supplied
Synthesis of the 21st Century Skills (4C) Based Physics Education Research In Indonesia
Authors: Hidayatullah Zul , Wilujeng Insih , Nurhasanah Nurhasanah , Gusemanto Theofilus Gratiamus , Makhrus Muh.
Published: January 2021

The development of life in the 21st century requires a variety of skills that one must master. Physics learning in schools has a central role in providing 21st-century skills to students. Physics learning is an integrated field that facilitates 21st-century skills and much research is being done in this field. The purpose of this research is to provide a review or general overview related to 21st-century skills-based physics learning research (Communication, Collaboration, Critical Thinking, and Problem Solving, and Creativity and Innovation) in Indonesia. This type of research is a literature study. The articles analyzed are articles published in Sinta-accredited national journals with publication years ranging from 2015-2020 and Scopus indexed international journals, as well as journal research fields focusing on evaluation and learning physics. The number of articles analyzed was 300 articles from national and international journals. From 2015 to 2020, critical thinking skills were the most researched topic with a percentage of 12% and 27% of researchers did not mention the physics topic studied in their research. A lot of learning research, especially physics learning, focuses on a quantitative approach in solving problems in the field of physics education in this case related to 21st-century skills. Most of the 4C skills-based physics learning research uses a relatively small sample of under 100 samples with the majority of the research locations being found mostly focused on Bali-Nusra and Java. The research subjects most frequently researched regarding 21st-century skills are high school level (SMA/SMK/MA).
Pentingnya Membangkitkan Motivasi Kerja Dalam Meningkatkan Produktivitas Kerja Aparatur Sipil Negara
Authors: Firdaus Firdaus
Published: January 2021

Adanya persoalan terabaikannya budaya kerja birokrasi. Salah satunya adalah motivasi kerja sehingga berdampak pada melemahnya produktivitas kerja pegawai. Padahal pegawai perlu mengembangkan budaya motivasi kerja dalam rangka meningkatkan produktivitas kerjanya. Tujuan penelitian ini menjelaskan pengaruh motivasi kerja terhadap produktivitas kerja pegawai. Penelitian ini menggunakan metode penelitian kuantitatif dengan jenis penelitian asosiatif. Hasil penelitian ini menunjukkan bahwa 50,5% motivasi kerja pegawai pada Sekretariat Daerah Kabupaten Padang Pariaman secara signifikan mempengaruhi produktivitas kerja dengan kekuatan pengaruh sebesar 71.7%, sementara 49,5% dipengaruhi oleh faktor lain.
DETERMINAN PENGANGGURAN LULUSAN PERGURUAN TINGGI DI INDONESIA TAHUN 2018
Authors: Astriani Vina , Nooraeni Rani
Published: January 2021

Abstrak Pengangguran merupakan salah satu permasalahan kompleks yang dihadapi oleh setiap negara berkembang di dunia, termasuk Indonesia. Berdasarkan data resmi Badan Pusat Statistik (BPS), jumlah pengangguran di Indonesia sejak tahun 2015 sampai dengan tahun 2018 tidak pernah bernilai lebih sedikit dari 7 juta orang, di mana jumlah Tingkat Pengangguran Terbuka (TPT) lulusan perguruan tinggi masih termasuk tinggi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang memengaruhi pengangguran lulusan perguruan tinggi di Indonesia tahun 2018 dengan menggunakan analisis regresi logistik biner. Adapun determinan pengangguran lulusan perguruan tinggi adalah umur, status kawin dan status KRT berpengaruh signifikan dan negatif terhadap pengangguran lulusan perguruan tinggi. Sedangkan, jenis kelamin dan sektor pekerjaan berpengaruh signifikan dan positif terhadap pengangguran lulusan perguruan tinggi. Kata Kunci: Pengangguran, Lulusan perguruan tinggi, Regresi Logistik Biner.     Abstract Unemployment is one of the complex problems faced by every developing country in the world, including Indonesia. Based on official data from Statistics Indonesia (BPS), the number of unemployed people in Indonesia from 2015 to 2018 was never worth less than 7 million people, where the number of open unemployment rate (TPT) of college graduates is still high. This study aims to determine the factors that influence unemployment of tertiary education graduates in Indonesia in 2018 by using binary logistic regression analysis. The determinants of unemployment for college graduates are age, marital status and KRT status have a significant and negative effect on unemployment of college graduates. Meanwhile, gender and employment sector have a significant and positive effect on unemployment of college graduates. Keywords: Unemployment, College Graduates, Binary Logit Regression.
Analysis of Employee Discipline Implementation in the Regional Secretariat of North Central Timor District
Authors: Soares Johanes Eudes Manuel Atolan , Djani Wiliam , Tamunu Lenny Magdalena
Published: January 2021

AbstractIn connection with the work discipline of the state civil apparatus, the Government issued a regulation regarding employee discipline which contains obligations, prohibitions and sanctions for employees who violate. This regulation was made with the aim of improving the professionalism of civil servants, ensuring order, and the smooth execution of duties and accelerating decision making in the event of disciplinary violations of Civil Servants (PNS), as stipulated in Government Regulation Number 53 of 2010 concerning Civil Servant Discipline ( Civil servants). To improve discipline for the Civil Servants (PNS) of North Central Timor Regency, since 2013 the Regional Government has implemented the mandate set out in Government Regulation Number 53 of 2010. However, in its application there are still many employees who are not disciplined in their work. This research is intended to analyze and describe the implementation of Government Regulation No. 53/2010 concerning Civil Servant Discipline at the Regional Secretariat of Timor Tengah Utara Regency. This study uses descriptive qualitative methods and data analysis techniques Milles and Huberman. The results of the study show that the Civil Servants in the Regional Secretariat of North Central Timor Regency in terms of PNS discipline have not been optimal and the level of discipline of Civil Servants is still very low which is evidenced by the level of violations and the imposition of disciplinary sentences of Civil Servants year and the dominant types of violations were committed, namely moderate to serious violations. As for other problems, namely the lack of socialization related to PNS discipline at the Regional Secretariat of North Central Timor Regency based on Government Regulation number 53 of 2010, Lack of understanding of Civil Servants of existing regulations due to lack of interest in reading civil servants to applicable regulations, and lack of assertiveness and courage by the leadership. OPD in imposing disciplinary sanctions for Civil Servants who commit violationsKeywords : Work Discipline, government regulations (PP No 53/ 2010).
Pengembangan Media Pembelajaran Matematika Berbasis YouTube Pada Materi Perbandingan Trigonometri
Authors: Yudela Shintia , Putra Aan , Laswadi Laswadi
Published: January 2021

The use of technology in education is becoming increasingly common. So that in its development, educators must be able to take advantage of information and communication technology in the learning process. Efforts to use it are to increase the attractiveness of a learning process, one of which is by using the help of learning media. Because of this, this study aims to produce YouTube-based learning media on trigonometric comparison material, find out expert opinions and student responses to YouTube-based mathematics learning media on trigonometric comparison material from an angle. This research is a research development or Research and Development (R & D) using the Sugiyono procedure. This research was conducted at MAS Nurul Haq Semurup with the research subjects being students of class X. Data collection was carried out using interviews and questionnaires. The instrument used was a questionnaire using a Likert scale. Based on the results of the validation carried out by material experts and media experts, the percentage results were respectively 71% and 77% with valid criteria. Then the learning media was tested through 2 stages, namely small group trials and field trials. The average results obtained were 87.22% for small group trials and 88.16% for field trials with very practical interpretation criteria, so it can be concluded that YouTube-based mathematics learning media on trigonometric comparison material from an angle is valid and practical to use in learning. Overall the results of the study indicate that the learning media developed are suitable for use by students.
Upaya Meningkatkan Kemampuan Membaca Kata Melalui Metode Praktik Langsung dengan Kartu Huruf pada Anak Kelompok B TK Dharma Wanita II Mergowati Kecamatan Kedu Kabupaten Temanggung Semester II Tahun Pelajaran 2017/2018
Authors: Suratiyah Suratiyah
Published: January 2021

Efforts to improve the ability to read words are an effort that gradually increases or enhances the ability or skills of children in translating spoken or written letters that have certain meanings. The rationale so that this problem arises is the low ability to read at the beginning of Group B TK Dharma Wanita II Mergowati. The objectives of this study are: 1) To find out that through the direct practice of the method with letter cards it can improve the ability to read words of children in Group B TK Dharma Wanita II Mergowati, Kedu District, Temanggung Regency, Semester II, 2017/2018 Academic Year, 2) To determine the magnitude of the increase in ability reading words through direct practice methods with letter cards in Group B children TK Dharma Wanita II Mergowati, Kedu District, Temanggung Regency, Semester II, 2017/2018 Academic Year.The subjects of this study were students of Group B TK Dharma Wanita II Mergowati totaling 20 children. The research was conducted from March to April 2018. The data collection methods used were observation, documentation, and interviews.Based on the results of research and discussion, it can be concluded that through direct practice with lettercard media can improve the ability to read words of children in Group B TK Dharma Wanita II Mergowati, Kedu District, Temanggung Regency, Semester II, 2017/2018 Academic Year. This is evidenced by an increase in children's pre-action reading skills before the action only reached 10%, then after the improvement in Cycle I increased to 45%, and Cycle II became 85%, having met the predetermined maximum percentage of 80%. This success is marked by the child being able to pronounce letter symbols that symbolize it, the child is able to compose letters into a meaningful word, the child is able to name groups of pictures that have the same initial/last sound/letter, the child is able to read and write simple words.
FUZZY NEUTROSOPHIC RELATIONS
Authors: Arockiarani  , Jency Martina
Published: January 2021

The focus of this paper is to present the concept of fuzzy neutrosophic relations. Further we study the composition of fuzzy neutrosophic relations with the choice of t-norms and t-conorms and characterize their properties.
Identifikasi perubahan suhu udara dan curah hujan di Bogor
Authors: Hidayat Rahmat , Farihah Alfi Wardah
Published: January 2021

Climate datasets were analyzed to identify the changing climatic parameters and extreme events in Bogor, West Java. This study aims to analyze the characteristic of observational datasets in Baranangsiang and Dramaga, namely, air temperature and rainfall, and to indentify the changing structure of those climate parameters. The analysis has been conducted using RClimdex to understand the long-term changing air temperature and rainfall based on 10 indices for air temperature and 8 indices for rainfall. Results show that the rainfall in Baranangsiang has the daily mean of 10 mm/day and in Dramaga of 8 mm/day. The daily mean of air temperature in Baranangsiang and Dramaga is 27˚C and 25.5˚C, respectively. Generally, the declined slopes of the temperature indices in Barangsiang, namely, TN90p, TNx, TX10p, TNn, TXn, TR20, and SU25, indicate cooler temperature. In Dramaga, the increased temperature indices, namely, TN90p, TX90p, TXx, SU25, and TXn, indicate the warmer temperature. The rainfall indices generally decline, except for CDD, which indicate the increased consecutive dry days in Baranangsiang.
Stability of facial soft tissue contour and bone wall at single maxillary tooth gap in early implant placement with contour augmentation: A case report
Authors: Cheng-Yi Wang , Jimmy LianPing Mau
Published: January 2021

Stability of esthetic implant buccal soft and hard tissue contour using freeze-dried bone allograft in early implant placement with contour augmentation.
Potential psychosocial impact of COVID-19 on children: a scoping review of pandemics and epidemics
Authors: Merrill Kaitlyn A , William Trevyna NN , Joyce Kayla M , Roos Leslie E , Protudjer Jennifer L
Published: January 2021

Background

Physical distancing and health measures, such as school closures and work-at-home mandates, implemented to mitigate the transmission of COVID-19, will likely have far-reaching impacts on children’s psychosocial health and well-being. We aimed to examine extant literature on pandemics and epidemics to draw comparisons regarding COVID-19 on children’s psychosocial health and secondary outcomes, including nutritional, financial and child safety outcomes.

Methods

Articles were searched within the Medline, Global Health, PsycINFO, and CINAHL databases on 11 June 2020. Grey literature was also examined from the World Health Organization (WHO) and United Nations Children’s Fund (UNICEF) until 24 July 2020.

Results

A total of 8,332 articles were screened for eligibility by two independent reviewers. Of these, 7,919 and 413 articles were from academic databases and additional sources, respectively. Results on child outcomes were extracted and collated. Seventy-three articles met inclusion criteria. Children have faced significant challenges with 12% of articles indicating loneliness/depression, 19% anxiety, 7% grief, 10% stress-related disorders, 25% child abuse, 8% family conflict, and 12% stigma during pandemics/epidemics. Furthermore, 25% of articles indicated economic challenges, 23% negative academic impacts, 33% improper nutrition, and 21% reduced opportunities for play/increased screen time. These challenges were exacerbated among children who were female, have a disability, or who were a migrant/displaced child.

Conclusions

Pandemics and epidemics have had diverse and widespread negative consequences for children. Findings can inform the development and implementation of resources during the COVID-19 pandemic to protect child health and well-being.
The evolution of Genetic Molecular Map and phylogenetic tree of Coronavirus (COVID-19)
Authors: AL-Mutar Hayder A. H.
Published: January 2021

Coronavirus (COVID-19) is suspected to originate from an animal host (zoonotic) followed by a human to human transmission, The purpose of the present study is to determine the genetic affinity of a phylogenetic tree and conformation of protein between human and bat. Through study of genetic sequencing, as shown in the tree design of strains and genetic variants, the main cause of COVID-19 is the Bat Coronavirus RaTG13 (SARS) virus in ID: MN996532.1 and ID: MG772933.1 (24-Jul-2013 and Feb-2017) shows that the evolution of the Corona virus from 2003, 2013 to 2020 which has become the most deadly peak in humans, the virus evolved from the bat effect on Humans. Protein analysis show 98 change of amino acid form RaTG13 (SARS) virus to COVID-19 Homo sapiens. Consequently, this study increased our understanding of the genetic variety of the COVID-19 carried by bats. So we conclude that a protein conformation drawing shows high identity compatibility between a bat and a human
Subacute Toxicity of Brown Truffle (Terfezia claveryi) on Sprague-Dawley Rats
Authors: Dyary Hiewa O.
Published: January 2021

Brown truffle (Terfezia claveryi) is a wild fungi species collected and consumed by humans in Iraq, especially during the raining season, from February to April. However, the toxicological effects of this fungus have not been studied in humans. This study tested the subacute toxicity of brown truffle’s methanolic extract on a rat model. Daily oral doses of 200, 400, and 800 mg/kg were administered to adult Sprague-Dawley rat groups of both sexes for 14 days. There were no behavioral changes, no alterations in body weight, organ weight, and body weight gain (p>0.05) in the treated rats, compared to the untreated control group. The hematological and serum biochemical parameters did not show significant (p>0.05) differences from the control. Microscopic examinations of the brain, lungs, liver, spleen, kidney, and heart tissues revealed no pathological lesions in treated rats’ organs. These results imply that the administration of methanolic extract of T. claveryi to rats does not result in observable toxicity
PENGGUNAAN MOTOR LISTRIK 3 FASA DALAM SISTEM FEEDDING FARM DI PT. CHAROEN POKPHAND JAYA FARM UNIT SERANG 2
Authors: Rahmat Jihad , Irwanto Irwanto
Published: January 2021

Peternakan ayam di Indonesia pada saat ini kebanyakan masih bersifat konvensional. Penggunaan motor listrik 3 fasa ini memiliki tujuan untuk mempermudah pengusaha peternakan untuk pemberian pakan ayam yang biasanya dilakukan dengan cara menuangkan pakan pada ayam secara satu persatu menjadi sistem otomatis dalam pemberian pakan. Dalam hal ini pemberian pakan menjadi dapat terjadwal sehingga dibuatlah sistem fedding farm. Farm feeding system beroperasi untuk memberikan pakan kepada ayam secara otomatis berdasarkan jadwal yang sudah ditentukan. Pada analisa peneliti lakukan jadwal pemberian pakan dilakukan sebanyak 3 kali dalam sehari, dalam pengoperasian motor listriknya sendiri tidak mengalami kendala namun kendala yang terjadi terdapat pada jalur dan rantai yang digunakan sebagai penyaluran pakan pada ayam.
PEMANFAATAN LINGKUNGAN ALAM SEKITAR SEBAGAI SUMBER BELAJAR DAN MEDIA PEMBELAJARAN MATEMATIKA, IPA, DAN SENI BAGI PENDIDIKAN DAN PENGEMBANGAN KREATIFITAS ANAK DI KECAMATAN PEMULUTAN BARAT KABUPATEN OGAN ILIR
Authors: Irmeilyana Irmeilyana , Ngudiantoro Ngudiantoro , Affandi Azhar Kholiq , Setiawan Arum , Windusari Yuanita
Published: January 2021

Proses belajar mengajar harus dapat memberi kesempatan yang lebih banyak kepada siswa untuk bereksplorasi, sehingga pemahaman tentang konsep maupun pengertian dasar suatu pengetahuan khususnya Matematika dan IPA dapat dipahami oleh siswa dengan mudah.  Sumber-sumber belajar dapat ditemukan di lingkungan sekitar anak. Kehidupan flora dan fauna, kondisi sosial sangat menarik untuk diamati dan dibicarakan, yang merupakan informasi dan sumber belajar bagi anak tentang lingkungan hidup. Tujuan utama kegiatan PPM ini adalah untuk memberi informasi dan mengenalkan khalayak sasaran tentang pentingnya alternatif metode pengajaran konsep Matematika dan IPA bagi anak melalui pemanfaatan lingkungan alam sekitar sebagai sumber belajar dan media pembelajaran. Sumber-sumber belajar ini dihubungkan dengan konsep materi yang akan dipelajari. Khalayak sasaran pada kegiatan PPM ini adalah guru-guru di SD Negeri 10 Pemulutan Barat dan juga melibatkan beberapa siswa dari kelas III sampai kelas VI. Metode pelaksanaan kegiatan berupa visitasi dan penyuluhan. Kegiatan penyuluhan dilakukan melalui presentasi, peragaan, aplikasi ke siswa, serta diskusi. Demonstrasi beberapa beberapa contoh sumber belajar dari pemanfaatan alam sekitar dan pembuatan media peraga edukatif (dari kayu, tumbuhan, dan kertas bekas), dihubungkan dengan suatu konsep pada topik bahasan untuk mata pelajaran Matematika, IPA, gabungan keduanya, dan juga Kesenian. Uji coba penggunaan contoh produk kepada siswa dapat memotivasi mereka untuk mencoba membuat juga, melatih kreatifitas, serta dapat memotivasi mereka untuk belajar. Penyuluhan ini telah menambah informasi dan wawasan yang penting bagi guru untuk meningkatkan kompetensinya dalam mengajar dengan memanfaatkan sumber daya alam yang ada di sekitar sekolah sebagai media pembelajaran yang menyenangkan bagi anak.
Utilization of Cockle Shell (Anadara granosa) Powder as Partial Replacement of Fine Aggregates in Cement Brick
Authors:   Faculty of Civil Engineering and Built Environment, Universiti Tun Hussien Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, Sainudin Muhammad Shabery , Othman Nor Hazurina ,   Jamilus Research Center, Universiti Tun Hussien Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, Ismail Nurul Nabilah ,   Faculty of Civil Engineering and Built Environment, Universiti Tun Hussien Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, Wan Ibrahim Mohd. Haziman ,   Jamilus Research Center, Universiti Tun Hussien Onn Malaysia, 86400 Parit Raja, Batu Pahat, Johor, MALAYSIA, A. Rahim Masazurah ,   Fisheries Research Institute, Department of Fisheries Malaysia, 11960 Batu Maung, Penang, MALAYSIA
Published: January 2021

Waste from fishery sector such as seashells are widely used in construction and building materials in order to reduce waste quantity. This study investigates the utilization of cockle shell powder (CSP) as partial replacement for fine aggregates in producing cement brick (CB). Bricks specimen are designed with three different percentages of 5% (CSP5CB), 10% (CSP10CB) and 15% (CSP15CB) replacements including control cement brick (CCB). An analysis conduct in this study are included sieve and specific gravity for materials testing while compressive strength, density and water absorption are for harden specimens. A rectangular brick shape specimen with 200mm × 100mm × 100mm in volume were used then cured using tap water for 7 and 28 days. The result revealed that compressive strength for specimens containing CSP are higher compared to CCB specimens. Besides that, CSP brick given a higher density with 2381.25 kg/m3 and lower water absorption 0.31% contrast from control specimens. According to overall data collected, the optimum composition for CSP in cement brick was 5% which indicated higher compressive and lower water absorption. Thus, the incorporation of CSP as sand replacement in bricks could improve and enhance physical and mechanical developments of bricks with the increment of curing time.
Parametric Study on the Influence of Embedded SPR to the Performance of Square CFST Columns
Authors:   Department of Civil Engineering, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA, Abdullah Abdul Azim , Abdul Mutalib Azrul ,   Department of Civil Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, MALAYSIA, Baharom Shahrizan ,   Department of Civil Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, MALAYSIA, Wan Badaruzzaman Wan Hamidon ,   Department of Civil Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, MALAYSIA
Published: January 2021

Steel plate reinforcements (SPR) embedded into the concrete core of a concrete filled steel tube (CFST) column is a promising strengthening scheme. However, further study is required to understand the influence SPR on the strength and behaviour of a CFST column. Numerical models of the CFST columns are developed using finite element analysis. The models are verified with experimental results from past research. The models are in good agreement with the experimental study. Then, a parametric study is conducted to investigate the strength and behaviour of CFST columns embedded with various configuration of SPR. In which, the embedded SPR varies in quantity, thickness and height. The parametric study indicates that these factors have positive influence on the performance of the CFST columns. The performance of the columns is measured in terms of strength, stiffness and ductility. Results have shown that the performance of the columns increases with every increment of the quantity, thickness and height of SPR.
Biochemical Oxygen Demand, Nitrogen, Phosphorus and Navigational Carrying Capacities of Bengoh Reservoir for Potential Aquaculture and Recreational Developments
Authors:   Faculty of Engineering, Computing and Science,  Swinburne University of Technology, Jalan Simpang Tiga, 93350 Kuching, Sarawak, MALAYSIA, Yee Law Esther Lik , Ling Law Puong ,   Department of Civil Engineering, Faculty of Engineering,  Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MALAYSIA
Published: January 2021

This paper quantifies the biochemical oxygen demand (BOD), nitrogen (N), phosphorus (P) and navigational carrying capacities of Bengoh Reservoir for potential fish cage culture and recreational developments. The pollutant degradation coefficients (k) and pollutant carrying capacities (tons/day) of the reservoir were determined. The computed pollutant degradation coefficients were primarily based on the hydrological information of the catchment, hydraulic and operational details of the dam, and the targeted water quality standards of the river-connected Bengoh Reservoir. The maximum allowable pollutant loading rate (tons/year) defines the reservoir’s maximum Waste Assimilative Capacity (WAC) on specific pollutants (BOD, N and P), while in compliance to the targeted benchmark with the receivable pollutant loadings. It was found that the current BOD, TN and TP loading rates are 0.308 ton/day, 0.119 ton/day and 0.114 ton/day, respectively. To comply with Class I Standards of the National Water Quality Standards of Malaysia (NWQSM), the Maximum Allowable Loading Rates of BOD can be as high as 92.24 tons/day as compared to the current loading rate of 0.308 ton/day, maximum TN loading of 116.63 tons/day versus current 0.119 ton/day, and maximum TP loading at 125.54 tons/day versus current 0.114 ton/day. It was also found that the maximum number 218 cages (225 fish/cage) of Tilapia would be allowed in Bengoh Reservoir so as to comply with Class I of NWQSM. Based on the peak level of the reservoir recreational types of use in demand and the mix of public and private access, the navigational carrying capacity of the reservoir was estimated to be about 130 boats.
Эффект эсциталопрама в комбинации с витамином D3 на депрессивно-подобное поведение и уровень BDNF в гиппокампе овариоэктомированных крыс
Authors: Федотова Юлия Олеговна , Бараненко Денис Александрович
Published: January 2021

Оценивали эффекты эсциталопрама (10 мг/кг, внутрибрюшинно, 1 раз в сутки, в течение 4 недель) и витамина D3 (5 мг/кг, подкожно, 1 раз в сутки, в течение 4 недель) при комбинированном введении взрослым самкам крыс через 12 недель после овариоэктомии (ОЭ) в отношении поведенческих нарушений, индуцированных хроническим умеренным непредсказуемым стрессом в течение 4 недель. Для оценки уровня ангедонии, депрессивно-подобного поведения и двигательной активности использовали следующие методы: тест предпочтения сахарозы, тест Порсолта и тест «Открытое поле», соответственно. С помощью иммуноферментного анализа определяли концентрации кортикостерона и 25-ОН-витамина D3 в сыворотке крови, уровень нейротрофического фактора BDNF в гомогенате гиппокампа. Хроническое введение эсциталопрама в комбинации с витамином D3 снижало уровни ангедонии и депрессивно-подобного поведения на 15 %, p = 0,05, а также уменьшало уровень кортикостерона в крови на 23 %, p = 0,05 и повышало уровень BDNF в ткани гиппокампана 29 %, p = 0,05, по сравнению с показателями ОЭ самок, получавших только эсциталопрам.
A Novel End-to-End Anastomosis Technique in Vessels Smaller than 1 mm Diameter: the Zigana Method
Authors: YAŞAR Emrah Kağan , ALAGÖZ Murat
Published: January 2021

Introduction: Traditional end-to-end microvascular anastomoses, the sine qua non of reconstructive microsurgery, has disadvantages, such as narrowing in the anastomosis line, excessive suture use, and risks of rotation and injuring the posterior wall especially for vessels with small diameter. It is aimed to compare the traditional method with a novel end-to-end vascular anastomosis technique suitable for use in very narrow vessels.
Methods: Fifteen female Wister Albino rats weighing 235-275 g were used. The experimental (Zigana) technique was applied to the right femoral artery, and the traditional anastomosis technique to the left. Operative time, suture counts, permeability rates and bleeding time were analyzed at clinical evaluation, and endothelialization, inflammation, fibrosis, foreign body reaction, intimal hyperplasia, intimal injury, thrombus and necrosis at histopathological evaluation.
Results: Clinical evaluation revealed a longer operative time, lower suture count, and a shorter bleeding time with the Zigana technique, while permeability rates were the same with both methods. Similar thrombus, stenosis, inflammation, fibrosis, and foreign body reaction rates were observed in both groups at histopathological examination. Intimal hyperplasia rates were lower in the Zigana technique group, while no necrosis was encountered in either.
Conclusion: The Zigana Technique exhibited better suture use and bleeding time values than the traditional method, although the difference between the two groups was not statistically significant. It is thought that the Zigana technique, which can yield positive results even with vessels less than 1 mm in diameter, is capable of use in microvascular anastomoses in both clinical and experimental studies.
Çölyak Hastalığının Genetik Allel Dağılımının Değerlendirilmesi ve Türkiye Literatür Taraması
Authors: DEMİRBAŞ Fatma , SANRI Aslıhan , DİNLER ÇALTEPE Gönül , COMBA Atakan , KALAYCI Ayhan Gazi 
Published: January 2021

Amaç: Çölyak hastalığı (ÇH), genetik yatkınlığı olan bireylerde, glutene kalıcı duyarlılık sonucu gelişen, otoimmün, sistemik hastalıktır. Bu çalışmanın amacı, ÇH’nin klinik, laboratuar özellikleri ve HLA doku tiplerinin geriye dönük değerlendirilmesidir.Ayrıca lieratür taramasıyla HLA doku tipleri açısından Türkiye’de bölgelere göre farklılık ve benzerliklerin incelenmesidir.
Yöntem: Çalışmaya, Temmuz 2017- Ekim 2018 tarihleri arasında ÇH tanısıyla izlenen ve genetik çalışması uygulanan 104 çocuk alındı. Google Scholarda Türkiye’de ÇH ve HLA genotiplendirme ile yapılan çalışmalar tarandı (n=11 çalışma) ve bölgelere ayrıldı.
Bulgular: Çalışmaya alınan 104 hastanın 67’si kız (%64,4) ve ortalama tanı yaşı 7,9±2,38 yıl(10ay-17,2yıl) idi. Hastalarımızın HLA grupları %59,6 DQ2, %26,9 DQ8 ve %13,4 DQ2+DQ8 saptandı. Literatürdeki çalışmalar bölgeler göre değerlendirildiğinde bizim de içinde bulunduğumuz Karadeniz bölgesinde HLADQ2 %63,7 ve HLADQ8 %21,1 sıklıkla görülürken, bölgemize benzer oranlarda genotip sıklığı Akdeniz ve Doğu Anadolu bölgelerinde görülmektedir. İç Anadolu HLADQ2 %87,4 ve Marmara bölgesinde %83,6 ile daha yüksek frekansta görülmektedir. Çalışmamızda, DQA1*05 %65,4 ve DQB1*02 %12,5 oranında bulundu. Türkiye’deki diğer çalışmalarda (Marmara, Karadeniz, İç, Doğu ve Güneydoğu Anadolu Bölgeleri) görülme sıklığı DQA1*05%69,8 ve DQB1*02 %27,7 idi.
Çalışmamızda HLA DQB1*02 homozigot olan hastalarda (%12,5) boy kısalığı, ishal, demir eksikliği anemisi, Marsh3 evre ve akrabalarında ÇH daha yüksekti.
Sonuç: Çölyak hastalığında HLA-DQ analizi bölgesel sıklığın belirlenmesi genetik analiz maliyetini azaltmak ve bölgesel dağılıma göre özellikle semptomsuz tarama hastalarında genotiplenme yapılması erken tanı kolaylığı sağlayabilir.
The Effect of Pouring Time on Dimensional Accuracy of Polyvinyl Siloxane Impression Materials
Authors: EKŞİ ÖZSOY Hilal , NAJAFOVA Lamia , BOYACIOĞLU Hayal , KRTULMUS Huseyin
Published: January 2021

Objective: The aim of this study was to evaluate of the dimensional accuracy of Polyvinylsiloxane (PVS) impression materials (Spirias, Imicryl, Konya, Turkey and Variotime, Heraeus, Hanau, Germany) by using stone models after different pouring time (1 hour and 24 hours).
Methods: A standard maxillary dentulous acrylic model was selected as master model. Two linear measurements were selected on each sample for the evaluation of the models (x: 13-23 distance, y: 13-26 distance). A total of 40 samples were divided into 4 groups according to the impression brands and pouring time (n=10). All of measurements were made with CEREC SW 4.2.3 software (Sirona Dental System, GmbH, Bensheim, Germany) using “distance” tools of the programme. Statistical analysis was performed by using the IBM SPSS Statistics, Version 25 (IBM SPSS Statistics for Windows, IBM Corporation, Armonk, NY). A value of p<0.05 was considered statistically significant.
Results: The relationship between different pouring times (1 hour and 24 hours) was not statistically significant (p>0.05). When the paired relations with the master model are evaluated, t test and p values show that there is statistically significant difference (p<0.05).
Conclusion: When compared with the main model, PVS materials for both brands show dimensional distortion. For PVS impression materials, the pouring of the impressions does not make any difference.
Ultrason Eşliğinde Perkütan Yolla Yapılan Karaciğer Biyopsi Uygulaması: Kocaeli Üniversitesi Girişimsel Radyoloji Deneyimi
Authors: ÇAKIR Özgür
Published: January 2021

Amaç: Ultrason (US) eşliğinde perkütan karaciğer biyopsisi, halen kronik karaciğer hastalığı ve karaciğer kitleleri yönetiminde halen altın standart yöntemdir. Çalışmamızda, Kocaeli Üniversitesi Tıp Fakültesi Girişimsel Radyoloji kliniğinde US eşliğinde son beş yılda yapılan karaciğer biyopsilerinin endikasyonları, kullanılan iğne özellikleri, hastaya ait diğer hastalıkları ve demografik verilerin değerlendirilmesi çalışmamızın amacını oluşturmaktadır.
Yöntem: Ocak 2015-Mayıs 2020 arasında hastanemizde perkütan karaciğer biyopsisi yapılan hastaların endikasyonları, komplikasyonları, histolojik bulguları değerlendirilmiştir.
Bulgular: Perkütan karaciğer biyopsi 264 hastada yapılmıştır. Karaciğer biyopsi endikasyonları içerisinde hepatit B(HBV) (%29,2) en sık endikasyon olup diğer endikasyonları sırasıyla malign kitleler (%22), non-alkolik yağlı karaciğer hastalığı (NAYKH) (%11,7), ilaca bağlı karaciğer hastalığı (İKH) (%11,4), Alkol (%9,5), hepatit C (HCV) (%9,5), Oto immun hepatit (%6,8)’dir.
Sonuç: US eşliğinde perkütan karaciğer biyopsi, hastanede yatan ve ayaktan başvuran hastalarda başarı ile uygulanan hızlı, güvenli, etkili ve minimal invaziv bir biyopsi işlemidir.
İnmeli Hastalarda Robotik Rehabilitasyonun El Fonksiyonları ve Günlük Yaşam Aktiviteleri Üzerine Etkisi
Authors: ÇEKMECE Çiğdem , SADE Ilgın
Published: January 2021

Amaç: Bu retrospektif çalışma ile kronik inmeli hastalarda üst ekstremite robotik rehabilitasyonun el fonksiyonları ve günlük yaşam aktivitelerine (GYA) olan katkısının incelenmesi amaçlanmıştır.
Yöntem: İnme sonucu hemipleji gelişmiş ve üst ekstremite rehabilitasyon programına alınmış çalışma için uygun bulunan 39 hastanın dosyası değerlendirmeye dahil edildi. Hasta kayıt dosyalarından hastaların yaş, cinsiyet, hastalık (inme) süresi (ay), hemiplejik taraf, Brunnstrom evrelemesi, Modifiye Ashworth Skalası (MAS)’tan oluşan demografik verileri alındı. Ayrıca hastaların üst ekstremite fonksiyonel gelişimini ve GYA katılımı değerlendiren Jebsen Taylor El Fonksiyon Testi (JTEFT) ve Kanada Aktivite Performans Ölçeği (KAPÖ) tedavi öncesi ve tedavi sonrası test kayıtları incelendi.
Bulgular: Çalışmaya katılan hastaların 19’u (%52) kadın iken 17’si (%48) erkekti ve yaş ortalamaları 50,2±2,02 idi. JTEFT’nin tedavi sonrası değerlendirmelerinde 7 alt parametrenin 2’sinde fark bulunmazken (iri hafif nesneleri kaldırma (p=0,074) ve iri ağır nesneleri kaldırma (p=0,079)), diğer 5 parametrede istatistiksel anlamlı fark olduğu saptandı (p<0,005). Hastaların 3 haftalık tedavi sonrası KAPÖ’nün performans ve memnuniyet olan her 2 alt parametresinde istatistiksel olarak anlamlı gelişme olduğu gözlendi (KAPÖ/performans (p=0,004); KAPÖ/memnuniyet (p=0,002)).
Sonuç: Yapmış olduğumuz bu çalışmada konvansiyonel tedavi programı planlanan inmeli hastalara iş-uğraşı tedavisi ile birlikte uygulanan üst ekstremite robot yardımlı tedavinin bireylerin el fonksiyonlarını geliştirdiği ve aktivite-performans katılımında iyileşmeye katkı sağladığı düşüncesindeyiz.
Could Inflammation Related Hemogram Parameters Be an Indicator of Diabetes Mellitus?
Authors: SÖZEN Mehmet , ÇETİNASLAN Berrin , CANTÜRK Zeynep , SELEK Alev , GEZER Emre , DEMİRHAN Yeliz , CETIN Yonca
Published: January 2021

Objective: Subclinical chronic inflammation plays an important role in the pathogenesis of type 2 diabetes mellitus (DM) and inflammation-related hemogram parameters have been proposed as an indicator of inflammation. In our study, we aimed to compare the hemogram parameters of normal oral glucose tolerance test (OGTT), prediabetes (preDM) and newly diagnosed type 2 DM patients.
Methods: Medical data of the patients who underwent 75 gr OGTT in the endocrinology outpatient clinic of our institution between february 2019 and december 2019 were obtained from the database and analyzed retrospectively. The test results were divided into 3 groups as normal OGTT, preDM and DM. Anthropometric measurements of patients, HbA1c and hemogram parameters were recorded.
Results: A total of 496 cases (246 normal OGTT, 105 patients with preDM and 145 patients with DM) were included in the study. Fasting plasma glucose (FPG) and HbA1c levels of men were higher than women (p<0.05). There was no significant difference between the three groups in terms of inflammation-related hemogram parameters. But, there was a positive correlation between FPG and MPV to platelet ratio (MPR) in diabetic patients (r=0.173; p=0.037).
Conclusion: Hemogram parameters associated with inflammation are easily calculated and cheap indices. However, they are not strong markers in new diagnosis, HbA1c ≤6.5% diabetic patients and prediabetic patients.
Life increase in friction surfaces with coatings with electro-machining
Authors: Matlakhov Vitaliy
Published: January 2021

A technology for life increase in friction surfaces on the basis of the combination of coating methods and further electro-machining is considered. The possibilities for such processing are revealed and the results of comparative trials are shown.
Türkiye’de Hekimlik Mesleğinde Mecburi Hizmet Yükümlülüğünün Tıp Tarihi, Tıp Hukuku ve Tıp Etiği Açısından Değerlendirilmesi
Authors: KELEŞ Şükrü
Published: January 2021

Giriş: Türkiye Cumhuriyeti’nin kuruluşunun ilk yıllarından günümüze dek hekimler için mecburi hizmet uygulaması, kamu hizmetinde bir ödevi ya da yükümlülüğü işaret etmektedir. Ödev ya da yükümlülük kavramlarının hukuktaki kullanımlarının dışında ahlaki bağlamının da olması mecburi hizmet ile ilgili yürürlüğe konan normların tıp tarihi, tıp hukuku ve tıp etiği boyutları ile birarada değerlendirilmesi gerektiğini düşündürmektedir.Amaç: Bu çalışmada hekimlik mesleğinde yasal açıdan düzenlenmiş mecburi hizmet kavramının anlam içeriğini açıklamak, hukuksal metinlerde nasıl ele alındığını incelemek, oluşturulan normların değersel anlam içeriği hakkında bilgi üretmek amaçlanmaktadır. Yöntem: Çalışma kapsamında mecburi hizmet kavramının tıp alanındaki akademik çalışmalarda ve 1923 yılından günümüze dek yürürlüğe girmiş olan hukuksal metinlerde nasıl yer aldığı incelenmiş ve elde edilen bilgiler etik açıdan değerlendirilmiştir. Bulgular: Tıp alanındaki ilk uygulamaların izini 19. yüzyıla dek sürebildiğimiz mecburi hizmet, günümüzde devlet hizmeti yükümlüğü olarak ifade edilmektedir. Mecburi hizmet ile devlet hizmeti yükümlülüğünün anlam içeriği birbiriyle örtüşmektedir. Akademik çalışmalarda ve hukuksal metinlerde mecburi hizmet ile ilgili normlar hem tıbbın varlık amacına hizmet etmekte hem de devletin vatandaşlara sağlık hizmeti sunma sorumluluğuna vurgu yapmaktadır. Sonuç: Mecburi hizmet yükümlülüğü, uluslararası sözleşmelerle uyumlu olarak ve hekimlerin özlük haklarını koruma altına alarak sağlık hizmeti gereksinimi olan bütün yurttaşlara sağlık hizmetinin eşit şekilde verilmesine katkı sağlamaktadır. Bu bağlamda hekimler açısından mecburi hizmet, hukuksal yükümlülüğün ötesinde etik ve ahlaki bir sorumluluğa işaret etmektedir.