bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Influencing the Spatio–Temporal Variability of Aerosol Optical Depth over the Arid Region of Northwest China
Authors: Zhang Fei
Published: December 2023

Aerosol optical depth (AOD) is an important physical variable used to characterize atmospheric turbidity for the management and control of air pollution. This study aims to analyze the factors influencing the spatial and temporal variability in AOD across the arid region of Northwest China (ARNC) using MODIS Aqua C006 aerosol product data from 2008 to 2017. In terms of natural and socioeconomic factors, the correlation coefficient (R) was used to identify the most influential factor in the AOD changes. The results show that AOD values in spring and summer were much higher than those in autumn and winter, especially in spring. In general, AOD had an insignificant decreasing trend, with a small overall changing range. Spatial analysis revealed a significantly decreasing trend, mostly across the Gobi Desert area, which is located in the western region of the ARNC. From the perspective of natural factors, AOD was positively correlated with air temperature (AT), wind speed (WP), land surface temperature (LST), and the digital elevation model (DEM) and negatively correlated with precipitation, relative humidity (RH), and the normalized difference vegetation index (NDVI). The greatest positive correlation, with a maximum R value of 0.8, was found between AOD and wind speed. By contrast, AOD and relative humidity had the strongest negative correlation, with R values of −0.77. In terms of anthropogenic factors, gross domestic product (GDP), secondary industry, and population density were the three major anthropogenic factors that influenced the changes in AOD changes in this region. In general, the effects of anthropogenic factors on AOD are more significant in areas with high urban population densities.
The Structural and Thermal Characteristics of Musa paradisiaca L. Lignin for Carbon Footprint Reduction Applications
Authors: Odili Chiosa Cletus , Olanrewaju Oludolapo Akanni , Ofordile Cyprian Onyedikachi , Adeosun Samson Oluropo
Published: December 2023

The need for the use of suitable natural alternative materials to oil-derived carbon-based materials, largely because of carbon IV oxide emissions and the attendant global health and environmental impact, has led to the discovery of lignin, a biomass-derived material, as a precursor for carbon fibre (CF) manufacture and as a reinforcement for biologically derived polymers like polylactide (PLA) with a variety of biomedical and industrial applications. This study investigated the thermal, structural, and compositional properties of lignin extracted from the pseudostem of Musa paradisiaca L. (the plantain tree). Dried and milled plantain pseudostem was pretreated using diethyl ether. Lignin was extracted from the untreated and pretreated pseudostem samples using 5M HCl for 1 h at 200 °C and 250 °C (acid hydrolysis). The results revealed that lignin obtained from pretreated pseudostem at 200 °C and 250 °C possesses superior thermal stability, as shown by the thermogram, with a DTGmax of 429.97 °C and 442.62 °C in contrast to 397.22 °C and 382.53 °C for lignin from untreated pseudostem due to the removal of volatile impurities and unwanted constituents after pretreatment. The FTIR spectrum of the extracted lignin samples shows similar absorption bands, like 1703.4 cm−1 (C=O–conjugated carbonyl group), 1606–1602 cm−1 (C=C stretching–aromatic compounds, benzene ring), 1315 cm−1 (C-O stretching–syringyl units), and 1200.2 cm−1 (C-H stretching, guaiacyl units), with the pretreated biomass having higher transmittance (%) values, indicating increased purity after pretreatment. The results presented above showed that lignin has been successfully extracted and can serve as a potential precursor for the production of carbon fibre, thereby reducing dependence on fossil-fuel-based precursors, with a reduction in carbon dioxide emission pollution.
Role of an Ultra-Large Coal-Fired Power Plant in PM2.5 Pollution in Taiwan
Authors: Tsai Chang-You , Chen Tu-Fu , Chang Ken-Hui
Published: December 2023

Taichung Power Plant (TPP) is Taiwan’s largest coal-fired power plant and is considered a major source of air pollution. During periods of deteriorating air quality, it is often required to reduce the load to reduce emissions. However, frequent power load shedding not only requires cost but also requires safety considerations. Therefore, it is necessary to explore the role that thermal power plant emissions play in air pollution in Taiwan. This study employed the Community Multiscale Air Quality modeling system with the brute-force method to analyze the PM2.5 concentration contributed by TPP. The results showed that among the various air basins in Taiwan, the Yun-Chi-Nan air basin (YCNAB), located to the south of TPP, was most severely affected by TPP’s emissions, with an annual average affected concentration of 1.0 µg m−3 (3.3%). However, when serious PM2.5 pollution events (daily concentration > 70 µg/m3) occurred due to low wind speeds, the Central Taiwan air basin (CTAB), where TPP is located, became the area most severely affected by TPP’s emissions. The low wind speed was caused by the interaction between the easterly wind field around Taiwan and Taiwan’s north–south mountain ranges. When this happens, TPP’s emissions would have a greater impact on the PM2.5 concentration at nearby stations in the CTAB and YCNAB, up to about 11%. Overall, on pollution days caused by low wind speeds, the largest TPP load reduction (40%) still had a certain effect as an emergency measure to improve the high PM2.5 pollution in central and southern Taiwan.
Spatially Heterogeneous Effects of Atmospheric Circulation on Greenland Ice Sheet Melting
Authors: Wang Hejing , Luo Dehai , Chen Yanan , Ge Yao
Published: December 2023

The melting of the Greenland ice sheet (GrIS) in summer has rapidly and significantly increased in recent decades, especially for the northern GrIS. Circulation related to GrIS melting is important for understanding the contribution of the GrIS to the global sea level. In this paper, we used the SOM method to obtain three spatial patterns of GrIS melting based on model output data: overall melting, northern melting, and southern melting patterns. We also examined their linkages to the observed atmospheric circulation. GrIS melting is primarily related to Greenland blocking (GB), while different types of GB are responsible for different melting patterns. The overall and northern melting patterns are both associated with high-latitude GB, which is associated with the decay and westward movement of mid-latitude and high-latitude European blocking (EB), respectively. It is found that the generation of mid-latitude and high-latitude EBs are related to mid-latitude eastern North Atlantic warming and Greenland–Norskehavet–North Sea warming, respectively, while the movement of EB is related t upstream weakened zonal wind anomalies. Furthermore, the southern melting pattern is linked to mid-latitude GB, which is associated with the wave train from the East Pacific to Southern Greenland through North America and further related to the mid-latitude of East Pacific warming.
Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism
Authors: Gubin Denis , Danilenko Konstantin , Stefani Oliver , Kolomeichuk Sergey , Markov Alexander , Petrov Ivan , Voronin Kirill , Mezhakova Marina , Borisenkov Mikhail , Shigabaeva Aislu , Yuzhakova Natalya , Lobkina Svetlana , Weinert Dietmar , Cornelissen Germaine
Published: December 2023

This study explores the relationship between the light features of the Arctic spring equinox and circadian rhythms, sleep and metabolic health. Residents (N = 62) provided week-long actigraphy measures, including light exposure, which were related to body mass index (BMI), leptin and cortisol. Lower wrist temperature (wT) and higher evening blue light exposure (BLE), expressed as a novel index, the nocturnal excess index (NEIbl), were the most sensitive actigraphy measures associated with BMI. A higher BMI was linked to nocturnal BLE within distinct time windows. These associations were present specifically in carriers of the MTNR1B rs10830963 G-allele. A larger wake-after-sleep onset (WASO), smaller 24 h amplitude and earlier phase of the activity rhythm were associated with higher leptin. Higher cortisol was associated with an earlier M10 onset of BLE and with our other novel index, the Daylight Deficit Index of blue light, DDIbl. We also found sex-, age- and population-dependent differences in the parametric and non-parametric indices of BLE, wT and physical activity, while there were no differences in any sleep characteristics. Overall, this study determined sensitive actigraphy markers of light exposure and wT predictive of metabolic health and showed that these markers are linked to melatonin receptor polymorphism.
Biomolecules of Muscle Fatigue in Metabolic Myopathies
Authors: Schirinzi Erika , Ricci Giulia , Torri Francesca , Mancuso Michelangelo , Siciliano Gabriele
Published: December 2023

Metabolic myopathies are a group of genetic disorders that affect the normal functioning of muscles due to abnormalities in metabolic pathways. These conditions result in impaired energy production and utilization within muscle cells, leading to limitations in muscle function with concomitant occurrence of related signs and symptoms, among which fatigue is one of the most frequently reported. Understanding the underlying molecular mechanisms of muscle fatigue in these conditions is challenging for the development of an effective diagnostic and prognostic approach to test targeted therapeutic interventions. This paper outlines the key biomolecules involved in muscle fatigue in metabolic myopathies, including energy substrates, enzymes, ion channels, and signaling molecules. Potential future research directions in this field are also discussed.
Physics of Ice Nucleation and Antinucleation: Action of Ice-Binding Proteins
Authors: Melnik Bogdan S. , Glukhova Ksenia A. , Sokolova (Voronova) Evgeniya A. , Balalaeva Irina V. , Garbuzynskiy Sergiy O. , Finkelstein Alexei V.
Published: December 2023

Ice-binding proteins are crucial for the adaptation of various organisms to low temperatures. Some of these, called antifreeze proteins, are usually thought to inhibit growth and/or recrystallization of ice crystals. However, prior to these events, ice must somehow appear in the organism, either coming from outside or forming inside it through the nucleation process. Unlike most other works, our paper is focused on ice nucleation and not on the behavior of the already-nucleated ice, its growth, etc. The nucleation kinetics is studied both theoretically and experimentally. In the theoretical section, special attention is paid to surfaces that bind ice stronger than water and thus can be “ice nucleators”, potent or relatively weak; but without them, ice cannot be nucleated in any way in calm water at temperatures above −30 °C. For experimental studies, we used: (i) the ice-binding protein mIBP83, which is a previously constructed mutant of a spruce budworm Choristoneura fumiferana antifreeze protein, and (ii) a hyperactive ice-binding antifreeze protein, RmAFP1, from a longhorn beetle Rhagium mordax. We have shown that RmAFP1 (but not mIBP83) definitely decreased the ice nucleation temperature of water in test tubes (where ice originates at much higher temperatures than in bulk water and thus the process is affected by some ice-nucleating surfaces) and, most importantly, that both of the studied ice-binding proteins significantly decreased the ice nucleation temperature that had been significantly raised in the presence of potent ice nucleators (CuO powder and ice-nucleating bacteria Pseudomonas syringae). Additional experiments on human cells have shown that mIBP83 is concentrated in some cell regions of the cooled cells. Thus, the ice-binding protein interacts not only with ice, but also with other sites that act or potentially may act as ice nucleators. Such ice-preventing interaction may be the crucial biological task of ice-binding proteins.
The Interaction of Microbiome and Pancreas in Acute Pancreatitis
Authors: Zhang Can , Li Guanqun , Lu Tianqi , Liu Liwei , Sui Yuhang , Bai Rui , Li Le , Sun Bei
Published: December 2023

Acute pancreatitis (AP) is a common acute abdomen disease characterized by the pathological activation of digestive enzymes and the self-digestion of pancreatic acinar cells. Secondary infection and sepsis are independent prognosticators for AP progression and increased mortality. Accumulating anatomical and epidemiological evidence suggests that the dysbiosis of gut microbiota affects the etiology and severity of AP through intestinal barrier disruption, local or systemic inflammatory response, bacterial translocation, and the regulatory role of microbial metabolites in AP patients and animal models. Recent studies discussing the interactions between gut microbiota and the pancreas have opened new scopes for AP, and new therapeutic interventions that target the bacteria community have received substantial attention. This review concentrates on the alterations of gut microbiota and its roles in modulating gut–pancreas axis in AP. The potential therapies of targeting microbes as well as the major challenges of applying those interventions are explored. We expect to understand the roles of microbes in AP diagnosis and treatment.
Oral Diseases and Adverse Pregnancy Outcomes in Sub-Saharan Africa: A Scoping Review
Authors: Adebayo Ezekiel Taiwo , Abodunrin Olunike Rebecca , Adewole Ifeoluwa E. , Salako Abideen Olurotimi , Lusher Joanne , Akinsolu Folahanmi Tomiwa , El Tantawi Maha , Alade Omolola Titilayo , Eleje George Uchenna , Ezechi Oliver Chukwujekwu , Foláyan Moréniké Oluwátóyìn
Published: December 2023

This scoping review mapped and critically reviewed the extant literature exploring associations between oral disease status and adverse pregnancy outcomes among women residing in sub-Saharan Africa. A literature search was conducted in July 2023 using PubMed, Cochrane Library and Google Scholar. The articles selected were those published in the English language between 1990 and 2022. After screening 833 potential studies, 15 articles met the inclusion criteria. Among these, 12 (80.0%) adopted a descriptive research design, while 3 (20.0%) used experimental methodologies. Eight (53.3%) studies were conducted in East Africa, fourteen (93.3%) studies were hospital-based, and one (6.7%) study was community-based. Periodontitis was linked with low birth weight, preterm birth, preterm birth and low birthweight, stunting, wasting, and underweight in most studies. Periodontitis was, however, not linked with adverse pregnancy outcomes in four studies. Caries was not linked with adverse pregnancy outcomes, but its sequalae was linked with low birth weight, preterm birth, neonatal stunting, and small head circumference. Two studies showed that periodontal diseases were linked with preeclampsia and chorioamnionitis. Maternal poor oral hygiene was linked with stunting. Two other studies showed no links between maternal periodontal disease and preterm premature rupture of membranes, eclampsia, spontaneous abortion, and vaginal bleeding. Furthermore, two intervention studies found that the treatment of periodontal diseases during pregnancy reduced the risk of adverse pregnancy outcomes. Further studies are needed to fully elucidate the effect size of the links observed between oral diseases and adverse pregnancy outcomes in sub-Saharan Africa.
Survey of Multimodal Medical Question Answering
Authors: Demirhan Hilmi , Zadrozny Wlodek
Published: December 2023

Multimodal medical question answering (MMQA) is a vital area bridging healthcare and Artificial Intelligence (AI). This survey methodically examines the MMQA research published in recent years. We collect academic literature through Google Scholar, applying bibliometric analysis to the publications and datasets used in these studies. Our analysis uncovers the increasing interest in MMQA over time, with diverse domains such as natural language processing, computer vision, and large language models contributing to the research. The AI methods used in multimodal question answering in the medical domain are a prominent focus, accompanied by applicability of MMQA to the medical field. MMQA in the medical field has its unique challenges due to the sensitive nature of medicine as a science dealing with human health. The survey reveals MMQA research to be in an exploratory stage, discussing different methods, datasets, and potential business models. Future research is expected to focus on application development by big tech companies, such as MedPalm. The survey aims to provide insights into the current state of multimodal medical question answering, highlighting the growing interest from academia and industry. The identified research gaps and trends will guide future investigations and encourage collaborative efforts to advance this transformative field.
Bionic Design and Optimization on the Flow Channel of a Legged Robot Joint Hydraulic Drive Unit Based on Additive Manufacturing
Authors: Huang Zhipeng , Du Chenhao , Wang Chenxu , Sun Qianran , Xu Yuepeng , Shao Lufang , Yu Bin , Ma Guoliang , Kong Xiangdong
Published: December 2023

The joint hydraulic drive unit (HDU) serves as a pivotal element in enabling the high-performance movements of legged robots. Functioning as the conduit linking the oil source and the actuator, the hydraulic flow channel significantly impacts actuator performance. Hence, optimizing the HDU flow channel becomes imperative, enhancing not only HDU efficiency but also the overall system performance. This paper introduces a novel approach by aligning the hydraulic flow channel of the joint HDU with the arteriovenous layout of the cardiac vascular system, departing from the conventional machining flow channel model. Through simulations determining the optimal range of the vascular branch radius and angle, this study guides the design optimization of the joint HDU flow channel. With the primary optimization goal of reducing pressure loss, the study compares simulation outcomes of various flow channel models—linear, variable excessive radius, and the multidimensional Bessel curve—tailored to suit the arrangement specifics of the joint HDU. Further validating these designs, the flow channels are fabricated using additive manufacturing for experimental verification. The integration of simulation analyses and pressure loss testing reveals a remarkable reduction of over 40% in pressure loss for the bionic flow channel compared to the conventional machining form. This empirical evidence strongly substantiates the bionic flow channel’s superior efficacy in pressure loss reduction. The findings presented herein offer valuable insights for the development of low-loss flow channels in joint HDUs, thereby presenting a new avenue for designing energy-efficient, high power-to-weight ratio legged robots.
Handheld Biosensor System Based on a Gradient Grating Period Guided-Mode Resonance Device
Authors: Chiang Chien Chieh , Tseng Wen-Chun , Tsai Wen-Tsung , Huang Cheng-Sheng
Published: December 2023

Handheld biosensors have attracted substantial attention for numerous applications, including disease diagnosis, drug dosage monitoring, and environmental sensing. This study presents a novel handheld biosensor based on a gradient grating period guided-mode resonance (GGP-GMR) sensor. Unlike conventional GMR sensors, the proposed sensor’s grating period varies along the device length; hence, the resonant wavelength varies linearly along the device length. If a GGP-GMR sensor is illuminated with a narrow band of light at normal incidence, the light resonates and reflects at a specific period but transmits at other periods; this can be observed as a dark band by using a complementary metal oxide semiconductor (CMOS) underneath the sensor. The concentration of a target analyte can be determined by monitoring the shift of this dark band. We designed and fabricated a handheld device incorporating a light-emitting diode (LED) light source, the necessary optics, an optofluidic chip with an embedded GGP-GMR sensor, and a CMOS. LEDs with different beam angles and bandpass filters with different full width at half maximum values were investigated to optimize the dark band quality and improve the accuracy of the subsequent image analysis. Substrate materials with different refractive indices and waveguide thicknesses were also investigated to maximize the GGP-GMR sensor’s figure of merit. Experiments were performed to validate the proposed handheld biosensor, which achieved a limit of detection (LOD) of 1.09 × 10−3 RIU for bulk solution measurement. The sensor’s performance in the multiplexed detection of albumin and creatinine solutions at concentrations of 0–500 μg/mL and 0–10 mg/mL, respectively, was investigated; the corresponding LODs were 0.66 and 0.61 μg/mL.
Discovery of Novel Stimulators of Pax7 and/or MyoD: Enhancing the Efficacy of Cultured Meat Production through Culture Media Enrichment
Authors: Yu In-Sun , Choi Yae Rim , Choi Jungseok , Kim Mina K. , Jung Chang Hwa , Um Min Young , Kim Min Jung
Published: December 2023

The principles of myogenesis play crucial roles in the production of cultured meat, and identifying protein stimulators associated with myogenesis holds great potential to enhance the efficiency of this process. In this study, we used surface plasmon resonance (SPR)-based screening of a natural product library to discover ligands for Pax7 and MyoD, key regulators of satellite cells (SCs), and performed cell-based assays on Hanwoo SCs (HWSCs) to identify substances that promote cell proliferation and/or differentiation. Through an SPR analysis, we found that six chemicals, including one Pax7+/MyoD− chemical, four Pax7+/MyoD+ chemicals, and one Pax7−/MyoD+ chemical, bound to Pax7 and/or MyoD proteins. Among four Pax7+/MyoD+ chemicals, parthenolide (0.5 and 1 µM) and rutin (100 and 200 µM) stimulated cell proliferation in the medium with 10% FBS similar to the medium with 20% FBS, without affecting differentiation. Adenosine, a Pax7−/MyoD+ chemical, accelerated differentiation. These chemicals could be potential additives to reduce the reliance of FBS required for HWSC proliferation and differentiation in cultured meat production.
Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study
Authors: Kaçar Sezgi , Coric Danko , Ometto Giovanni , Montesano Giovanni , Denniston Alastair K. , Keane Pearse A. , Uitdehaag Bernard M. J. , Crabb David P. , Schoonheim Menno M. , Petzold Axel , Strijbis Eva M. M.
Published: December 2023

Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (p = 0.629). In MS, VH scores declined with disease duration (β = −0.009, p = 0.004) and age (β = −0.007, p = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, p = 0.011) and white matter volume (NWMV, β = 0.001, p = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, p < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, p = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, p = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy.
May Female Autism Spectrum Be Masked by Eating Disorders, Borderline Personality Disorder, or Complex PTSD Symptoms? A Case Series
Authors: Carpita Barbara , Nardi Benedetta , Pronestì Cristiana , Parri Francesca , Giovannoni Federico , Cremone Ivan Mirko , Pini Stefano , Dell’Osso Liliana
Published: December 2023

Introduction: The prevalence of Autism Spectrum Disorder (ASD) is four times higher in males than females; however, females are significantly more likely to go undiagnosed due to the existence of a “female autistic phenotype”, a manifestation unique to females that conflicts with conventional, masculine conceptualizations of ASD. Furthermore, subthreshold autistic traits, which exert a significantly negative impact on quality of life and represent a vulnerability factor for the development of other psychopathological conditions, may remain even more under-recognized. Subsequently, many women with ASD may never receive a diagnosis or any resulting care, with serious consequences for their health. Aims: We aimed to describe two brief cases in order to confirm the diagnostic difficulties that ASD female undergo during their clinical evaluation and the possible alternative phenotype that they can manifest. Methods: We reported the cases of two young women on the autism spectrum that came to clinical attention only after the development of severe symptomatology attributed to other mental disorders, overlooking the presence of underlying autism spectrum features and a brief résumé of the literature on this topic. Results: These cases confirm the need for a timely and proper identification of females on the autism spectrum in order to prevent complications and improve the outcome. Conclusions: Research on gender differences could lead to a reexamination of the sex ratio in the prevalence of ASD and provide a better understanding of several psychiatric conditions that are frequently diagnosed in women, supporting the neurodevelopmental approach to psychopathology.
Familiarity Processing through Faces and Names: Insights from Multivoxel Pattern Analysis
Authors: Castro-Laguardia Ana Maria , Ontivero-Ortega Marlis , Morato Cristina , Lucas Ignacio , Vila Jaime , Bobes León María Antonieta , Muñoz Pedro Guerra
Published: December 2023

The way our brain processes personal familiarity is still debatable. We used searchlight multivoxel pattern analysis (MVPA) to identify areas where local fMRI patterns could contribute to familiarity detection for both faces and name categories. Significantly, we identified cortical areas in frontal, temporal, cingulate, and insular areas, where it is possible to accurately cross-classify familiar stimuli from one category using a classifier trained with the stimulus from the other (i.e., abstract familiarity) based on local fMRI patterns. We also discovered several areas in the fusiform gyrus, frontal, and temporal regions—primarily lateralized to the right hemisphere—supporting the classification of familiar faces but failing to do so for names. Also, responses to familiar names (compared to unfamiliar names) consistently showed less activation strength than responses to familiar faces (compared to unfamiliar faces). The results evinced a set of abstract familiarity areas (independent of the stimulus type) and regions specifically related only to face familiarity, contributing to recognizing familiar individuals.
Mismatch Responses to Speech Contrasts in Preschoolers with and without Developmental Language Disorder
Authors: Campos Ana , Tuomainen Jyrki , Tuomainen Outi
Published: December 2023

This study compared cortical responses to speech in preschoolers with typical language development (TLD) and with Developmental Language Disorder (DLD). We investigated whether top-down language effects modulate speech perception in young children in an adult-like manner. We compared cortical mismatch responses (MMRs) during the passive perception of speech contrasts in three groups of participants: preschoolers with TLD (n = 11), preschoolers with DLD (n = 16), and adults (n = 20). We also measured children’s phonological skills and investigated whether they are associated with the cortical discrimination of phonemic changes involving different linguistic complexities. The results indicated top-down language effects in adults, with enhanced cortical discrimination of lexical stimuli but not of non-words. In preschoolers, the TLD and DLD groups did not differ in the MMR measures, and no top-down effects were detected. Moreover, we found no association between MMRs and phonological skills, even though the DLD group’s phonological skills were significantly lower. Our findings suggest that top-down language modulations in speech discrimination may not be present during early childhood, and that children with DLD may not exhibit cortical speech perception deficits. The lack of association between phonological and MMR measures indicates that further research is needed to understand the link between language skills and cortical activity in preschoolers.
EEG Network Analysis of Depressive Emotion Interference Spatial Cognition Based on a Simulated Robotic Arm Docking Task
Authors: Yang Kai , Hu Yidong , Zeng Ying , Tong Li , Gao Yuanlong , Pei Changfu , Li Zhongrui , Yan Bin
Published: December 2023

Depressive emotion (DE) refers to clinically relevant depressive symptoms without meeting the diagnostic criteria for depression. Studies have demonstrated that DE can cause spatial cognition impairment. However, the brain network mechanisms underlying DE interference spatial cognition remain unclear. This study aimed to reveal the differences in brain network connections between DE and healthy control (HC) groups during resting state and a spatial cognition task. The longer operation time of the DE group during spatial cognition task indicated DE interference spatial cognition. In the resting state stage, the DE group had weaker network connections in theta and alpha bands than the HC group had. Specifically, the electrodes in parietal regions were hubs of the differential networks, which are related to spatial attention. Moreover, in docking task stages, the left frontoparietal network connections in delta, beta, and gamma bands were stronger in the DE group than those of the HC group. The enhanced left frontoparietal connections in the DE group may be related to brain resource reorganization to compensate for spatial cognition decline and ensure the completion of spatial cognition tasks. Thus, these findings might provide new insights into the neural mechanisms of depressive emotion interference spatial cognition.
The Discrepancy between Subjective and Objective Evaluations of Cognitive and Functional Ability among People with Schizophrenia: A Systematic Review
Authors: Harris Molly , Blanco Emily , Howie Hunter , Rempfer Melisa
Published: December 2023

Background: An important aspect of recovery in schizophrenia relates to one’s subjective, lived experience. Self-report is a subjective measurement method with yet-uncertain utility in the assessment of functioning among individuals diagnosed with schizophrenia-spectrum disorder. No review to date has comprehensively synthesized existing research to evaluate the degree of correspondence, or lack thereof, between subjective and objective assessments of cognitive and everyday functioning, nor how extant data can inform the use of self-reported information in treatment and research. Methods: A systematic review was completed to provide a broad perspective of the literature on this topic. Relevant manuscripts were identified via a search strategy using key terms in PubMed and PsycINFO and a review of manuscript bibliographies. Twenty-six studies met the inclusion criteria. Results: These studies show minimal to modest associations between subjective assessments of cognition and everyday functioning and objective assessments of these domains, including informant reports and neuropsychological and behavioral measures. Individuals with schizophrenia appear to overestimate their functioning when compared to objective measures. Depression and greater cognitive ability tend to predict greater correspondence between subjective and objective assessments of cognition and everyday functioning. Discussion: This review discusses how we might understand the low correspondence between subjective and objective measures of functioning and provides recommendations for using and eliciting self-reported information in the pursuit of recovery-centered practices.
The Effect of Length of Service in a Thermal Environment on Thermal Comfort and Mental Stress
Authors: Shin Young-Sub , Ko Jeong-Bae , Cha Dong-An , Hong Jae-Soo
Published: December 2023

An inappropriate thermal environment negatively impacts workers, causing mental stress and safety accidents. Unskilled workers are more vulnerable to industrial accidents and thermal stress compared with skilled workers due to suboptimal and unfamiliar work. Previous studies have focused on individual characteristics (such as gender, age, and race), with limited emphasis on the thermal comfort sensation. This study identified the preferred thermal environment according to work experience and how mental stress differed between unskilled and skilled workers by examining their thermal comfort sensation. Predicted mean vote (PMV) was used as an indicator of the thermal environment, and five environments were constructed for PMV: −2, −1, 0, 1, and 2. Participants were recruited among current workers and the public. Mental stress and thermal comfort sensation were assessed using heart rate variability and thermal comfort vote, respectively. This study demonstrated that the skilled group experienced higher mental stress and a lower thermal comfort sensation. Contrastingly, in the sensitivity analysis, the unskilled group exhibited greater sensitivity to changes in the thermal environment. Through a comprehensive analysis, this study derived an optimal PMV range for each group. The findings can provide a reference for configuring the optimal thermal environment of the workplace.
Prioritizing Subway Station Entrance Attributes to Optimize Passenger Satisfaction in Cold Climate Zones: Integrating Gradient Boosting Decision Trees with Asymmetric Impact-Performance Analysis
Authors: Ji Xian , Du Yu , Li Qi
Published: December 2023

Subway station entrances serve as crucial links between urban environments and underground transit systems and are particularly vital in cities with cold climates. Specialized design strategies are essential to address user needs and promote safety and comfort, thereby encouraging sustainable travel in harsh winter conditions. This research utilizes data from Harbin and Shenyang, two winter cities in China, to explore the nonlinear influences of subway entrance attributes on passenger satisfaction through the combined use of gradient-boosting decision trees and asymmetric impact-performance analysis. The findings indicate that most key attributes of subway entrances impact passenger satisfaction asymmetrically, highlighting the significance of their hierarchical importance in generating satisfaction. These attributes are categorized into frustrators, dissatisfiers, hybrids, satisfiers, and delighters, based on their asymmetry levels. Considering the current performance of these attributes, the study identifies priority for improvement at Harbin and Shenyang’s subway entrances. This aids urban designers and city managers in making informed decisions for urban development and enhancing the overall commuter experience in winter cities.
Development of Building Design Optimization Methodology: Residential Building Applications
Authors: Bae Yeonjin , Kim Donghun , Horton William Travis
Published: December 2023

Building design optimization is a highly complex problem, requiring long computational running processes because of the many options that exist when a building is being designed. This paper introduces an integrated approach through which to perform this optimization within an acceptable time frame. The approach includes the methods of variable selection, model simplification, and a sequential optimization process. Using singular value decomposition, a large number of design variables is reduced to a smaller subset that can be solved more quickly through the optimization algorithm. To expedite the variable selection process, a modeling approach that quickly simulates annual energy consumption was developed to replace full annual energy simulations. The developed methodology was applied to two residential buildings in the US, and the results are discussed herein. To assess the accuracy of the integrated optimization methodology, the optimized life cycle costs are compaa variables demonstrating the strongest contributions in the optimization study were identified. The proposed methodology significantly shortened the time requirements for the optimization processes of the two case studies by 74% and 84%; the optimized life cycle costs were within 0.05% and 0.06%, respectively, of the optimum point.
Progressive Collapse Resistance Assessment of a Multi-Column Frame Tube Structure with an Assembled Truss Beam Composite Floor under Different Column Removal Conditions
Authors: Zhao Rongguo , Chen Guangfei , Zhang Zaihua , Luo Wei
Published: December 2023

To estimate the progressive collapse resistance capacity of a multi-column frame tube structure with an assembled truss beam composite floor (ATBCF), pushdown analysis and nonlinear dynamic analysis are conducted for such a structure using the alternate load path (ALP) method. The bearing capacities of the remaining structures under three different work conditions, which are the side middle column removal, the edge middle column removal, and the corner column removal, are individually studied, and the collapse mechanism of the remaining structures is analyzed based on the aspects of the internal force redistribution and the failure mode of the second defense line. Simultaneously, the influence of the column failure time on the dynamic response of the remaining structure and the dynamic amplification coefficient is discussed. The results indicate that the residual bearing capacity of the remaining structure following the bottom corner column removal is higher than that of the one following the side or edge middle column removal, while the latter has a stronger plastic deformation capacity. When the ALP method is adopted to operate the progressive collapse analysis, it is reasonable to take the column failure time as 0.1 times the period of the first-order vertical vibration mode of the remaining structure, and it is suitable to set the dynamic amplification coefficient as 2.0, which is the ratio of the maximum dynamic displacement to the static displacement of the remaining structure under the transient loading condition.
Geopolymer Made from Kaolin, Diatomite, and Rice Husk Ash for Ceiling Thermal Insulation
Authors: Alvarado Cinthya , Martínez-Cerna Daniel , Alvarado-Quintana Hernán
Published: December 2023

In this study, geopolymers made of metakaolin (MK), diatomite (D), and rice husk ash (RHA) were developed for ceiling thermal insulation in houses to provide protection against cold temperatures. The influence of the constituent mixing ratio and the temperature of curing on the heat conductivity and compressive strength of the geopolymer was investigated. Specimens were formed according to a 10-level mix design with three replicates and subjected to curing at 40 °C and 80 °C. Heat conductivity and compressive strength were determined in accordance with established standards. The simplex lattice method was used to obtain the response surfaces, contour plots, and tracking curves. The geopolymers under study displayed a reduction in heat conductivity and an increase in compressive strength when the curing temperature was raised. The optimal mixing ratio to achieve a balance between the compressive strength and thermal conductivity of the geopolymers investigated was 0.50 MK and 0.50 RHA. Diatomite’s thermal insulation contribution is neutralized when crystals from the geopolymer gel fill the pore volume. The mixture’s optimal results were achieved when cured at 80 °C, demonstrating a thermal conductivity of 0.10 W/m·K and a compressive strength of 5.37 MPa.
Optimal Design of a Novel Large-Span Cable-Supported Steel–Concrete Composite Floor System
Authors: Tan Meiwen , Wu Yifan , Pan Wenhao , Liu Guoming , Chen Wei
Published: December 2023

This paper optimizes the design of a novel large-span cable-supported steel–concrete composite floor system in a simply supported single-span, single-strut configuration, aiming for cost-effective solutions and minimal steel consumption. The optimization considers various cross-sectional dimensions, adhering to building standards and engineering practices, and is based on a non-linear programming (NLP) algorithm. Parameters of live loads ranging from 2 to 10 kN/m2 and spans from 20 to 100 m are considered. The optimization results show that cable-supported composite floors with a single strut exhibit robust economic feasibility for spans of less than 80 m and live loads under 8 kN/m2. Compared to conventional composite floors with welded I-beams, the cable-supported system offers more cost-effective cross-sections and reduces steel consumption. The savings in economically equivalent steel consumption range from 20% to 60%. Discussion on the area ratio of cables to steel beam in the optimal cross-section reveals that the secondary load-bearing system (i.e., bending of the main beam with an effective span length of L/2) may require more steel in cases of ultra-large spans. Therefore, the economical efficiency of cable-supported composite beams with multiple struts and smaller effective span lengths warrants further exploration in future studies.
Effect of Rock Mass Disturbance on Stability of 3D Hoek–Brown Slope and Charts
Authors: Xu Jingshu , Wang Xinrui , Xie Pengfei , Wang Ruotong , Du Dianchun
Published: December 2023

The present study performs a stability analysis of a three-dimensional (3D) rock slope in disturbed rock masses following the Generalized Hoek–Brown (GHB) failure criterion. The factor of safety (FoS) of the slope is derived and the optimal solution is captured combining the limit analysis method and the strength reduction technique. It is indicated by the parametric analysis that the 3D geometric characteristics have a significant impact on slope stability such that FoS decreases sharply with the increase in the width-to-height ratio B/H within 0<B/H≤2.0 and thereafter reaches a constant value asymptotically. The FoS decreases more than 60% linearly when the disturbance factor D increases from 0 to 1.0. Stability charts and slope angle weight factor fβ_3D for 3D slopes are proposed to provide a convenient and straightforward approach to obtain the FoS solutions of 3D slopes. A case study was carried out to apply the stability charts on practical engineering cases, which showed that slope stability under two-dimensional (2D) plane strain will lead to conservative results, and a 3D stability analysis of slope is more appropriate, especially for a slope with a limited width.
New Frontiers in Monoclonal Antibodies for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Authors: Schipani Mattia , Rivolta Giulia Maria , Margiotta-Casaluci Gloria , Mahmoud Abdurraouf Mokhtar , Al Essa Wael , Gaidano Gianluca , Bruna Riccardo
Published: December 2023

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma. Approximately 60% of patients are cured with R-CHOP as a frontline treatment, while the remaining patients experience primary refractory or relapsed disease (R/R). The prognosis for R/R DLBCL patients who are neither eligible for autologous stem-cell transplantations nor CAR-T-cell treatment is poor, representing an important unmet need. Monoclonal antibodies (mAbs) have dramatically improved therapeutic options in anti-cancer strategies, offering new opportunities to overcome chemo-refractoriness in this challenging disease, even in cases of primary non-responder DLBCL. Several novel mAbs, characterized by different mechanisms of action and targets, are now available for R/R DLBCL. Unbound mAbs induce an immune response against cancer cells, triggering different mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), activation of antibody-dependent cell-mediated phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC). Antibody–drug conjugates (ADCs) and radioimmunotherapy (RIT), respectively, deliver a cytotoxic payload or a beta-emitter radionuclide to the targeted cells and nearby bystanders. Bispecific T-cell engagers (BiTes) and immune checkpoint inhibitors (ICIs) redirect and enhance the immune response against tumor cells. Here, we review therapeutic strategies based on monoclonal antibodies for R/R DLBCL.
A Ten-Year Real-Life Experience with Pazopanib in Uterine Leyomiosarcoma in Two High-Specialized Centers in Italy: Effectiveness and Safety
Authors: Mantiero Mara , Bini Marta , Polignano Maggie , Porcu Luca , Sanfilippo Roberta , Fabbroni Chiara , Parma Gabriella , Lapresa Mariateresa , Calidona Carmelo , Silvestri Cecilia , Franza Andrea , Raspagliesi Francesco , Colombo Nicoletta , Ducceschi Monika
Published: December 2023

Background: Uterine leiomyosarcoma (uLMS) is characterized by aggressive behavior associated with a high risk of relapse and mortality. Several therapeutic agents have been employed in the treatment of metastatic disease, with a poor objective response rate. Pazopanib, approved in 2012, is a multi-targeted, orally active small molecule that exerts its effects by inhibiting several tyrosine kinases. To date, poor research on real-life data has been conducted. We aimed to assess the effectiveness and safety of the drug in everyday clinical practice. Methods: We present results of multicenter retrospective data on 38 patients with heavily pretreated metastatic uLMS who underwent oral pazopanib during their therapeutic journey. Results: At a median follow-up of 8.6 months, the disease control rate was 55.2%, with 17% partial responses and 15 patients (39.5%) with stable disease. At a median follow-up of 8.6 months, median progression-free survival was 4 months, and median overall survival was 19.8 months. The most common grade 3 adverse events (AEs) drug-related were hepatic toxicities, diarrhea, hypertension, nausea, and vomiting (all of them with an incidence of 5% considering the whole study cohort). No grade 4 AEs occurred. Conclusions: Pazopanib in everyday clinical practice is safe and shows a good disease control rate with prolonged survival.