bluuebunny/crossref_metadata_2025 huggingface dataset:
The potential of Antheraea pernyi silk for spinal cord repair
Authors: Varone A. , Knight D. , Lesage S. , Vollrath F. , Rajnicek A. M. , Huang W.
Published: October 2017

One of the most challenging applications for tissue regeneration is spinal cord damage. There is no cure for this, partly because cavities and scar tissue formed after injury present formidable barriers that must be crossed by axons to restore function. Natural silks are considered increasingly for medical applications because they are biocompatible, biodegradable and in selected cases promote tissue growth. Filaments from wild Antheraea pernyi silkworms can support axon regeneration in peripheral nerve injury. Here we presented evidence that degummed A. pernyi filaments (DAPF) support excellent outgrowth of CNS neurons in vitro by cell attachment to the high density of arginine-glycine-aspartic acid tripeptide present in DAPF. Importantly, DAPF showed stiffness properties that are well suited to spinal cord repair by supporting cell growth mechano-biology. Furthermore, we demonstrated that DAPF induced no activation of microglia, the CNS resident immune cells, either in vitro when exposed to DAPF or in vivo when DAPF were implanted in the cord. In vitro DAPF degraded gradually with a corresponding decrease in tensile properties. We conclude that A. pernyi silk meets the major biochemical and biomaterial criteria for spinal repair, and may have potential as a key component in combinatorial strategies for spinal repair.
Outlining tectonic inheritance and construction of the Min Shan region, eastern Tibet, using crustal geometry
Authors: Xu Xiao , Gao Rui , Guo Xiaoyu , Li Wenhui , Li Hongqiang , Wang Haiyan , Huang Xingfu , Lu Zhanwu
Published: October 2017

The ongoing collision between India and Eurasia has created the Tibetan Plateau, which features high elevations and large crustal thicknesses. The easternmost portion of the plateau has long been a key region for studying the uplift mechanism of the Tibetan Plateau, especially after the 2008 Ms. 7.9 Wenchuan earthquake. However, previous studies have assumed that easternmost Tibet is tectonically homogeneous, and the tectonic significance of the Min Shan has been overshadowed by that of its more conspicuous neighbour, the Longmen Shan region. Here, we describe the crustal geometry of the Min Shan region using two newly obtained deep seismic reflection profiles. In this study, we identify an upper-lower crust mechanical decoupling within the Min Shan region; the Min Shan region is tectonically delineated by an inherited boundary fault zone, the Huya fault zone, which was responsible for triggering the 2017 Jiuzhaigou M 7.0 earthquake. Together with the gravity dataset and previous studies in this area, the outlined crustal geometry indicated that crustal-scale shortening at the eastern plateau margin is a primary mechanism driving uplift, although extensive uplift might have occurred due to the decoupled shortening between the upper and lower crust.
Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons
Authors: Tsai David , Morley John W. , Suaning Gregg J. , Lovell Nigel H.
Published: October 2017

Electrical stimulation is an important tool in neuroscience research and clinically. In the retina, extensive work has revealed how the retinal ganglion cells respond to extracellular electrical stimulation. But little is known about the responses of other neuronal types, and more generally, how the network responds to stimulation. We conducted a survey of electrically evoked responses, over a range of pulse amplitudes and pulse widths, for 21 cell types spanning the inner two layers of the rabbit retina. It revealed: (i) the evoked responses of some neurons were charge insensitive; (ii) pulse-width sensitivity varied between cell types, allowing preferential recruitment of cell types; and (iii) 10–20 Hz damped oscillations across retinal layers. These oscillations were generated by reciprocal excitatory / inhibitory synapses, at locations as early as the cone-horizontal-cell synapses. These results illustrate at cellular resolution how a network responds to extracellular stimulation, and could inform the development of bioelectronic implants for treating blindness.
Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis
Authors: Li Wenzhe , Ma Huailei , Zhang Jin , Zhu Ling , Wang Chen , Yang Yanlian
Published: October 2017

CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same subtype of breast cancer. Systematic comparison of their functions is still lacking. We investigated the expression of CD44, CD24 and ALDH1 in different subtypes of breast cancer cells, and explored their relationship with cancer progression. We defined a parameter CD44/CD24 ratio to present the expression level of CD44 and CD24 and found that high CD44/CD24 ratio and ALDH1+ are both indicators for cancer malignancy, but play different functions during tumor progression. High CD44/CD24 ratio is more related to cell proliferation and tumorigenesis, which is confirmed by mammosphere formation and tumorigenesis in xenotransplanted mice. ALDH1+ is a stronger indicator for cell migration and tumor metastasis. Suppression of CD44 and ALDH1 by siRNA led to decreased tumorigenicity and cell migration capacity. The combination of high CD44/CD24 ratio and ALDH1+ would be a more reliable way to characterize CSCs. Moreover, both high CD44/CD24 ratio and ALDH1+ were conserved during metastasis, from the primary tumors to the circulating tumor cells (CTCs) and the distant metastases, suggesting the significant value of these CSC markers in assisting cancer detection, prognostic evaluation, and even cancer therapeutics.
All-angle Negative Reflection with An Ultrathin Acoustic Gradient Metasurface: Floquet-Bloch Modes Perspective and Experimental Verification
Authors: Liu Bingyi , Zhao Jiajun , Xu Xiaodong , Zhao Wenyu , Jiang Yongyuan
Published: October 2017

Metasurface with gradient phase response offers new alternative for steering the propagation of waves. Conventional Snell’s law has been revised by taking the contribution of local phase gradient into account. However, the requirement of momentum matching along the metasurface sets its nontrivial beam manipulation functionality within a limited-angle incidence. In this work, we theoretically and experimentally demonstrate that the acoustic gradient metasurface supports the negative reflection for all-angle incidence. The mode expansion theory is developed to help understand how the gradient metasurface tailors the incident beams, and the all-angle negative reflection occurs when the first negative order Floquet-Bloch mode dominates inside the metasurface slab. The coiling-up space structures are utilized to build desired acoustic gradient metasurface, and the all-angle negative reflections have been perfectly verified by experimental measurements. Our work offers the Floquet-Bloch modes perspective for qualitatively understanding the reflection behaviors of the acoustic gradient metasurface, and the all-angle negative reflection characteristic possessed by acoustic gradient metasurface could enable a new degree of the acoustic wave manipulating and be applied in the functional diffractive acoustic elements, such as the all-angle acoustic back reflector.
Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
Authors: St John-Williams Lisa , Blach Colette , Toledo Jon B. , Rotroff Daniel M. , Kim Sungeun , Klavins Kristaps , Baillie Rebecca , Han Xianlin , Mahmoudiandehkordi Siamak , Jack John , Massaro Tyler J. , Lucas Joseph E. , Louie Gregory , Motsinger-Reif Alison A. , Risacher Shannon L. ,   Alzheimer’s Disease Neuroimaging Initiative,   Alzheimer’s Disease Metabolomics Consortium, Saykin Andrew J. , Kastenmüller Gabi , Arnold Matthias , Koal Therese , Moseley M. Arthur , Mangravite Lara M. , Peters Mette A. , Tenenbaum Jessica D. , Thompson J. Will , Kaddurah-Daouk Rima
Published: October 2017

Alzheimer’s disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (ADNI) is creating a comprehensive biochemical database for AD. Using targeted and non- targeted metabolomics and lipidomics platforms we are mapping metabolic pathway and network failures across the trajectory of disease. In this report we present quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction. The dataset presented here is the first of eight metabolomics datasets being generated for broad biochemical investigation of the AD metabolome. We expect that these collective metabolomics datasets will provide valuable resources for researchers to identify novel molecular mechanisms contributing to AD pathogenesis and disease phenotypes.
High-throughput DFT calculations of formation energy, stability and oxygen vacancy formation energy of ABO3 perovskites
Authors: Emery Antoine A. , Wolverton Chris
Published: October 2017

ABO3 perovskites are oxide materials that are used for a variety of applications such as solid oxide fuel cells, piezo-, ferro-electricity and water splitting. Due to their remarkable stability with respect to cation substitution, new compounds for such applications potentially await discovery. In this work, we present an exhaustive dataset of formation energies of 5,329 cubic and distorted perovskites that were calculated using first-principles density functional theory. In addition to formation energies, several additional properties such as oxidation states, band gap, oxygen vacancy formation energy, and thermodynamic stability with respect to all phases in the Open Quantum Materials Database are also made publicly available. This large dataset for this ubiquitous crystal structure type contains 395 perovskites that are predicted to be thermodynamically stable, of which many have not yet been experimentally reported, and therefore represent theoretical predictions. The dataset thus opens avenues for future use, including materials discovery in many research-active areas.
A virtual climate library of surface temperature over North America for 1979–2015
Authors: Kravtsov Sergey , Roebber Paul , Brazauskas Vytaras
Published: October 2017

The most comprehensive continuous-coverage modern climatic data sets, known as reanalyses, come from combining state-of-the-art numerical weather prediction (NWP) models with diverse available observations. These reanalysis products estimate the path of climate evolution that actually happened, and their use in a probabilistic context—for example, to document trends in extreme events in response to climate change—is, therefore, limited. Free runs of NWP models without data assimilation can in principle be used for the latter purpose, but such simulations are computationally expensive and are prone to systematic biases. Here we produce a high-resolution, 100-member ensemble simulation of surface atmospheric temperature over North America for the 1979–2015 period using a comprehensive spatially extended non-stationary statistical model derived from the data based on the North American Regional Reanalysis. The surrogate climate realizations generated by this model are independent from, yet nearly statistically congruent with reality. This data set provides unique opportunities for the analysis of weather-related risk, with applications in agriculture, energy development, and protection of human life.
Highly active 3-dimensional cobalt oxide nanostructures on the flexible carbon substrates for enzymeless glucose sensing
Authors: Kannan Palanisamy , Maiyalagan Thandavarayan , Marsili Enrico , Ghosh Srabanti , Guo Longhua , Huang Youju , Rather Jahangir Ahmed , Thiruppathi Dharmaraj , Niedziolka-Jönsson Joanna , Jönsson-Niedziolka Martin
Published: October 2017

3-Dimensional cobalt oxide nanostructures on the flexible carbon substrates for enzymeless glucose sensing.
OCT imaging detection of brain blood vessels in mouse, based on semiconducting polymer nanoparticles
Authors: Yang Shaozhuang , Chen Haobin , Liu Liwei , Chen Bingling , Yang Zhigang , Wu Changfeng , Hu Siyi , Lin Huiyun , Li Buhong , Qu Junle
Published: October 2017

Optical Coherence Tomography (OCT) is a valuable technology that has been used to obtain microstructure images of tissue, and has several advantages, though its applications are limited in high-scattering tissues.
Quantification of a bacterial secondary metabolite by SERS combined with SLM extraction for bioprocess monitoring
Authors: Morelli Lidia , Andreasen Sune Zoëga , Jendresen Christian Bille , Nielsen Alex Toftgaard , Emnéus Jenny , Zór Kinga , Boisen Anja
Published: October 2017

The yield of a bacterial secondary metabolite was quantified using SERS-based sensing combined with a SLM μfluidic device enabling sample extraction and enrichment.
A new analytical technique for the extraction and quantification of microplastics in marine sediments focused on easy implementation and repeatability
Authors: Sánchez-Nieva Julio , Perales José Antonio , González-Leal Juan Maria , Rojo-Nieto Elisa
Published: October 2017

A new analytical approach has been developed to extract and quantify microplastics from sediments, using routine laboratory equipment and NaCl solutions.
An ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry method for the detection of steroidal glycoalkaloids in potato samples
Authors: Nie Xu-Heng , Guo Hua-Chun
Published: October 2017

An ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method has been optimized and validated to simultaneously monitor steroidal glycoalkaloids (SGAs), α-chaconine and α-solanine, in potato samples stored under natural indoor conditions in Kunming.
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography
Authors: Mazzoccanti G. , Ismail O. H. , D’Acquarica I. , Villani C. , Manzo C. , Wilcox M. , Cavazzini A. , Gasparrini F.
Published: October 2017

An extreme ee was measured for Δ9-THC in medicinal marijuana, by applying the ICCA method under eUHPSFC, using sub-2 μm Whelk-O1 columns.
Facile synthesis of CoNix nanoparticles embedded in nitrogen–carbon frameworks for highly efficient electrocatalytic oxygen evolution
Authors: Wan Jiawei , Chen Wenxing , Chen Chen , Peng Qing , Wang Dingsheng , Li Yadong
Published: October 2017

We report a pyrolysis reduction method to prepare highly dispersed CoNix nanoparticles embedded in nitrogen–carbon frameworks, which exhibit excellent performance in electrocatalytic oxygen evolution.
NIR-absorbing dye functionalized hollow mesoporous silica nanoparticles for combined photothermal–chemotherapy
Authors: Zhang Yuanyuan , Qu Qiuyu , Cao Xiang , Zhao Yanli
Published: October 2017

Multifunctional nanocarriers consisting of hollow mesoporous silica nanoparticles loaded with doxorubicin and then capped by a complex between disulfide linked β-cyclodextrin and adamantane functionalized indocyanine dye are developed for improved anticancer efficacy through combined photothermal–chemotherapy.
Polymorphism in crystals of bis(4-bromophenyl)fumaronitrile through vapour phase growth
Authors: Jensen Torsten T. , Potticary Jason , Terry Lui R. , Bruce Macdonald Hannah E. , Brandenburg Jan Gerit , Hall Simon R.
Published: October 2017

We have linked polymorphic selectivity of crystals of bis(4-bromophenyl)fumaronitrile grown via physical vapour transport and their fluorescence to the lattice properties of each polymorph.
Study of three solvates of sulfamethazine
Authors: Ahuja Dipali , Bannigan Pauric , Rasmuson Åke C.
Published: October 2017

Three solvates for sulfamethazine (SMT) are reported. The solvent interacts with SMT in a strong hydrogen bonding network imparting stability to the solvate structure.
Crystal genes in a marginal glass-forming system of Ni50Zr50
Authors: Wen T. Q. , Tang L. , Sun Y. , Ho K. M. , Wang C. Z. , Wang N.
Published: October 2017

Glass-forming motifs with B2 traits are found. A perfect Ni-centered B33 motif deteriorates the glass-forming ability of Ni50Zr50.
Polarization mechanisms of dielectric materials at a binary liquid interface: impacts on electrowetting actuation
Authors: Bonfante G. , Roux-Marchand T. , Audry-Deschamps M.-C. , Renaud L. , Kleimann P. , Brioude A. , Maillard M.
Published: October 2017

We explored polarization mechanisms at the interface between a dielectric material (an electrolyte) and an insulating liquid, during electrowetting actuation.
Atomically thin non-layered nanomaterials for energy storage and conversion
Authors: Dou Yuhai , Zhang Lei , Xu Xun , Sun Ziqi , Liao Ting , Dou Shi Xue
Published: October 2017

The research progress of atomically thin non-layered nanomaterials on energy storage and conversion applications is reviewed in this work.
Slow magnetic relaxation in luminescent mononuclear dysprosium(iii) and erbium(iii) pentanitrate complexes with the same LnO10 coordination geometry
Authors: Chen Lei , Zhou JianJun , Yuan Aihua , Song You
Published: October 2017

Two isostructural mononuclear Dy and Er pentanitrate complexes with a LnO10 coordination geometry show slow magnetic relaxation and photoluminescence properties.
Novel half-sandwich iridium(iii) imino-pyridyl complexes showing remarkable in vitro anticancer activity
Authors: Li JuanJuan , Guo Lihua , Tian Zhenzhen , Tian Meng , Zhang Shumiao , Xu Ke , Qian Yuchuan , Liu Zhe
Published: October 2017

This class of iridium imino-pyridyl complexes is attractive for development as new anticancer agents.
On verdigris, part I: synthesis, crystal structure solution and characterisation of the 1–2–0 phase (Cu3(CH3COO)2(OH)4)
Authors: Bette Sebastian , Kremer Reinhard K. , Eggert Gerhard , Tang Chiu C. , Dinnebier Robert E.
Published: October 2017

Cu3(CH3COO)2(OH)4 a historic blue verdigris pigment phase was synthesised and characterised by its spectroscopic and magnetic properties.
Growth of NiO nanorods, SiC nanowires and monolayer graphene via a CVD method
Authors: You Y. , Mayyas M. , Xu S. , Mansuri I. , Gaikwad V. , Munroe P. , Sahajwalla V. , Joshi R. K.
Published: October 2017

Green approaches for producing high purity advanced materials have always been a challenging task.
Rational design of patchy colloidsvialandscape engineering
Authors: Long Andrew W. , Ferguson Andrew L.
Published: October 2017

A new approach for inverse design of self-assembling building blocks by rational sculpting of the underlying self-assembly free energy landscape.
Investigation of the structure and opto-electronic properties of substituted 2,2′-bithiophenes as π-building blocks: a joint experimental and theoretical study
Authors: Andicsová-Eckstein A. , Tokár K. , Kozma E. , Tokárová Z.
Published: October 2017

Substituted 2,2′-bithiophenes with enhanced properties and suppressed aggregation in polymers are revealed to be used as π-linkers in D–π–A materials.
Spectromicroscopic observation of a live single cell in a biocompatible liquid-enclosing graphene system
Authors: Yu Seong Uk , Lee Hwiwon , Cho Woo Jong , Kim Chulhyun , Kang Moon Cheol , Shin Hyun-Joon , Kim Namdong , Hahn Sei Kwang , Kim Kwang S.
Published: October 2017

Scanning transmission X-ray microscopy combined with liquid-enclosing graphene system offering biocompatible wet environment allows on-the-spot visualization of biochemical responses of live cells.
The light-induced pyro-phototronic effect improving a ZnO/NiO/Si heterojunction photodetector for selectively detecting ultraviolet or visible illumination
Authors: Yin Bing , Zhang Heqiu , Qiu Yu , Luo Yingmin , Zhao Yu , Hu Lizhong
Published: October 2017

In this work, we fabricate a ZnO/NiO/Si heterojunction photodetector, which successfully realizes selective detection of UV or visible light in a single photodetector.
Transition metal-catalyzed C–H bond functionalization in multicomponent reactions: a tool toward molecular diversity
Authors: Wan Jie-Ping , Gan Lu , Liu Yunyun
Published: October 2017

Research advances in transition metal-catalyzed multicomponent C–H functionalization reactions over the last decade are summarized.
Tricyclanos: conformationally constrained nucleoside analogues with a new heterotricycle obtained from a d-ribofuranose unit
Authors: Kicsák Máté , Mándi Attila , Varga Szabolcs , Herczeg Mihály , Batta Gyula , Bényei Attila , Borbás Anikó , Herczegh Pál
Published: October 2017

Nucleoside analogues having a new N,O-containing tricycle in place of the ribose unit have been prepared by a diastereoselective cyclocondensation of Tris and dialdehydes obtained from ribofuranosyl nucleosides.
Investigation of the triazolinedione (TAD) reaction with tryptophan as a direct route to copolypeptide conjugation and cross-linking
Authors: Hanay S. B. , Brougham D. F. , Dias A. A. , Heise A.
Published: October 2017

The TAD reaction with tryptophan permits the modification of polypeptides omitting protection/deprotection routes or the use on non-natural amino acids.
In situ stabilizer formation from methacrylic acid macromonomers in emulsion polymerization
Authors: Schreur-Piet Ingeborg , Heuts Johan P. A.
Published: October 2017

Methacrylic acid oligomers containing a propenyl ω-endgroup were synthesized by CCTP and used as precursors to efficient stabilizers in surfactant-free emulsion polymerization.
Gelatin based dynamic hydrogelsviathiol–norbornene reactions
Authors: Perera M. Mario , Ayres Neil
Published: October 2017

Gelatin based dynamic stiffening–softening hydrogels were preparedviathiol–norbornene click reactions.
A new class of platinum(ii) complexes with the phosphine ligand pta which show potent anticancer activity
Authors: Živković M. D. , Kljun J. , Ilic-Tomic T. , Pavic A. , Veselinović A. , Manojlović D. D. , Nikodinovic-Runic J. , Turel I.
Published: October 2017

A series of 16 Pt(ii) complexes with 8-hydroxyquinolines and sulfoxide/phosphine ligands were synthetized, characterized and evaluated for cytotoxic and embryotoxic activity.
Indium(iii)-catalyzed intramolecular dearomative cycloaddition ofN-sulfonylaziridines to indoles: facile synthesis of tetracyclic pyrroloindoline skeletons
Authors: Cao Bo , Wei Yin , Shi Min
Published: October 2017

A facile and versatile indium(iii)-catalyzed intramolecular dearomative cycloaddition ofN-sulfonylaziridines to indoles has been developed, selectively giving rigid tetracyclic pyrroloindoline skeletons in moderate to good yields.
Enhancing the performance and stability of carbon-based perovskite solar cells by the cold isostatic pressing method
Authors: Zhang Yangwen , Wang Jize , Liu Xue , Li Wangnan , Huang Fuzhi , Peng Yong , Zhong Jie , Cheng Yibing , Ku Zhiliang
Published: October 2017

The cold isostatic pressing method was used as a post-treatment process for enhancing the power conversion efficiency and stability of carbon-based perovskite solar cells without hole transport materials.
“Blinking” silica nanoparticles for optical super resolution imaging of cancer cells
Authors: Li Jia , Zong Shenfei , Wang Zhuyuan , Cui Yiping
Published: October 2017

A strategy to fabricate blinking silica nanoparticles is presented, which can be used in single molecule localization imaging.
Positive charge pesticide nanoemulsions prepared by the phase inversion composition method with ionic liquids
Authors: Zhao Xin , Zhu Yanqiu , Zhang Chenhui , Lei Jinmei , Ma Yue , Du Fengpei
Published: October 2017

We prepared highly stable positive charge nanoemulsions with ILs that possessed fine wetting and adhesive property on wheat leaf surfaces.
Asymmetric fabric supercapacitor with a high areal energy density and excellent flexibility
Authors: Liang Yunxia , Weng Wei , Yang Junjie , Liu Lianmei , Zhang Yang , Yang Lijun , Luo Xiaogang , Cheng Yanhua , Zhu Meifang
Published: October 2017

CNT/rGO and PPy were incorporated into tuned porous fabrics, serving as negative and positive electrodes, respectively. The resulting asymmetric supercapacitor possesses a super-high areal energy density of 0.26 mW h cm−2and excellent flexibility.
Detoxifying effects of ultrafiltration fractions of Dendrobium aphyllum peptides on chemical and AAPH-induced oxidative stress
Authors: Liu Huifan , Ma Juanjuan , Wu Hui
Published: October 2017

The antioxidative peptide fraction extracted from Dendrobium aphyllum displayed good detoxifying effects on chemical and AAPH-induced oxidative stress.
Dynamics of a water droplet on a hydrophobic inclined surface: influence of droplet size and surface inclination angle on droplet rolling
Authors: Yilbas Bekir Sami , Al-Sharafi Abudllah , Ali Haider , Al-Aqeeli Nasser
Published: October 2017

An understanding of the dynamic motion of a water droplet is critical to reduce the effort required to remove dust particles from such surfaces.
Revealing anisotropy and thickness dependence of Raman spectra for SnS flakes
Authors: Li Mingling , Wu Yiming , Li Taishen , Chen Yulin , Ding Huaiyi , Lin Yue , Pan Nan , Wang Xiaoping
Published: October 2017

The anisotropic Raman behavior of SnS flake is found to be strongly dependent on the thickness of flake.
Surface modification of piperazine-based nanofiltration membranes with serinol for enhanced antifouling properties in polymer flooding produced water treatment
Authors: Zhang Ruijun , Yu Shuili , Shi Wenxin , Wang Xiaoying , Cheng Jun , Zhang Zhiqiang , Li Li , Bao Xian , Zhang Bing
Published: October 2017

A facile membrane modification method with serinol to improve the membrane performance in the advanced treatment of polymer flooding produced water.
Thioester-functionalised and oxime-based hexametallic manganese(iii) single-molecule magnets
Authors: Rojas-Dotti Carlos , Martínez-Lillo José
Published: October 2017

Two novel oxime-based hexametallic manganese(iii) single-molecule magnets have been thioester-functionalised and characterised structurally and magnetically.
Nitrones and nucleobase-containing spiro-isoxazolidines derived from isatin and indanone: solvent-free microwave-assisted stereoselective synthesis and theoretical calculations
Authors: Maiuolo Loredana , Merino Pedro , Algieri Vincenzo , Nardi Monica , Di Gioia Maria Luisa , Russo Beatrice , Delso Ignacio , Tallarida Matteo Antonio , De Nino Antonio
Published: October 2017

Here, we present a highly efficient approach to nucleobase-containing spiro-isoxazolidines with potential biological activity starting from isatinyl/indanyl nitrones.
Simple and green route for preparation of tin phosphate catalysts by solid-state grinding for dehydration of glucose to 5-hydroxymethylfurfural (HMF)
Authors: Rao Kasanneni Tirumala Venkateswara , Souzanchi Sadra , Yuan Zhongshun , Ray Madhumita B. , Xu Chunbao (Charles)
Published: October 2017

This work demonstrated a simple and green method for the synthesis of tin phosphate (SnP) catalysts for glucose to HMF transformation.
Sublimable chloroquinolinate lanthanoid single-ion magnets deposited on ferromagnetic electrodes
Authors: Miralles Sara G. , Bedoya-Pinto Amilcar , Baldoví José J. , Cañon-Mancisidor Walter , Prado Yoann , Prima-Garcia Helena , Gaita-Ariño Alejandro , Mínguez Espallargas Guillermo , Hueso Luis E. , Coronado Eugenio
Published: October 2017

Magnetic analogues of Alq3 give rise to molecular/ferromagnetic interfaces with specific hybridization, opening the door to interesting spintronic effects.
Tetrabutylammonium cations for moisture-resistant and semitransparent perovskite solar cells
Authors: Poli Isabella , Eslava Salvador , Cameron Petra
Published: October 2017

Tetra-butylammonium cations have been partially substituted for methylammonium cations in perovskite thin films. The stability of devices stored under ambient conditions was enhanced by the presence of TBA and cells with high mol% TBA were found to have reasonable efficiencies while being semi-transparent.
A high-performance flexible piezoelectric energy harvester based on lead-free (Na0.5Bi0.5)TiO3–BaTiO3 piezoelectric nanofibers
Authors: Liu Bao , Lu Bin , Chen Xiaoqiu , Wu Xin , Shi Shengjie , Xu Lei , Liu Yun , Wang Feifei , Zhao Xiangyong , Shi Wangzhou
Published: October 2017

A high-performance flexible piezoelectric energy harvester based on lead-free nanofibers.
From lamellar to hierarchical: overcoming the diffusion barriers of sulfide-intercalated layered double hydroxides for highly efficient water treatment
Authors: Wang Jing , Li Zhenyu , Hu Na , Liu Lizhi , Huang Chuanhui , Yang Qingfeng , Wang Yanru , Suo Yourui , Wang Tie , Wang Jianlong
Published: October 2017

A geometry-induced effect overcomes diffusion constraints to enhance mass transfer and decontamination, presenting a novel approach to water purification.
Understanding the stability of mixed A-cation lead iodide perovskites
Authors: Charles Bethan , Dillon Jessica , Weber Oliver J. , Islam M. Saiful , Weller Mark T.
Published: October 2017

Thin films of the mixed A-cation phase MA1−xFAxPbI3 have been shown experimentally and computationally to have greater kinetic and thermodynamic stability towards decomposition.
Sharp convex gold grooves for fluorescence enhancement in micro/nano fluidic biosensing
Authors: Chen Zhi-Hui , Shi Hua , Wang Yang , Yang Yibiao , Liu Shaoding , Ye Han
Published: October 2017

This work presents a sharp convex gold groove for fluorescence enhancement in micro/nano fluidic biosensing.
Improved quality of electrochemically polymerized luminescent films on Au-nanoparticle modified electrodes: Au-nanoparticle induced interfacial nucleation and fast electron transfer
Authors: Wang Rong , Liu Cao , Zhou Xuehong , Liu Linlin , Ma Yuguang
Published: October 2017

Au-Nanoparticles induced interfacial nucleation and increased the electron-transfer rate of the EP process to improve the quality of EP films.
On the relations between the bandgap, structure and composition of the M–Si–N (M = alkali, alkaline earth or rare-earth metal) nitridosilicates
Authors: ten Kate Otmar M. , Zhang Zhijun , Hintzen H. T. (Bert)
Published: October 2017

The relations between the Si/N ratio and the bond lengths and bandgap of the M–Si–N nitridosilicates are investigated.
Connection between jets, winds and accretion in T Tauri stars
Authors: Nisini B. , Antoniucci S. , Alcalá J. M. , Giannini T. , Manara C. F. , Natta A. , Fedele D. , Biazzo K.
Published: October 2017

Mass loss from jets and winds is a key ingredient in the evolution of accretion discs in young stars. While slow winds have been recently extensively studied in T Tauri stars, little investigation has been devoted on the occurrence of high velocity jets and on how the two mass-loss phenomena are connected with each other, and with the disc mass accretion rates. In this framework, we have analysed the [O i]6300 Å  line in a sample of 131 young stars with discs in the Lupus, Chamaeleon and σ Orionis star forming regions. The stars were observed with the X-shooter spectrograph at the Very Large Telescope and have mass accretion rates spanning from 10-12 to 10-7M⊙ yr-1. The line profile was deconvolved into a low velocity component (LVC, | Vr | < 40 km s-1) and a high velocity component (HVC, | Vr | > 40 km s-1), originating from slow winds and high velocity jets, respectively. The LVC is by far the most frequent component, with a detection rate of 77%, while only 30% of sources have a HVC. The fraction of HVC detections slightly increases (i.e. 39%) in the sub-sample of stronger accretors (i.e. with log (Lacc/L⊙) >−3). The [O i]6300 Å  luminosity of both the LVC and HVC, when detected, correlates with stellar and accretion parameters of the central sources (i.e. L∗, M∗, Lacc, Ṁacc), with similar slopes for the two components. The line luminosity correlates better (i.e. has a lower dispersion) with the accretion luminosity than with the stellar luminosity or stellar mass. We suggest that accretion is the main drivers for the line excitation and that MHD disc-winds are at the origin of both components. In the sub-sample of Lupus sources observed with ALMA a relationship is found between the HVC peak velocity and the outer disc inclination angle, as expected if the HVC traces jets ejected perpendicularly to the disc plane. Mass ejection rates (Ṁjet) measured from the detected HVC [O i]6300 Å  line luminosity span from ~10-13 to ~10-7M⊙ yr-1. The corresponding Ṁjet/Ṁacc  ratio ranges from ~0.01 to ~0.5, with an average value of 0.07. However, considering the upper limits on the HVC, we infer a Ṁjet/Ṁacc  ratio < 0.03 in more than 40% of sources. We argue that most of these sources might lack the physical conditions needed for an efficient magneto-centrifugal acceleration in the star-disc interaction region. Systematic observations of populations of younger stars, that is, class 0/I, are needed to explore how the frequency and role of jets evolve during the pre-main sequence phase. This will be possible in the near future thanks to space facilities such as the James Webb space telescope (JWST).
Clustering the Orion B giant molecular cloud based on its molecular emission
Authors: Bron Emeric , Daudon Chloé , Pety Jérôme , Levrier François , Gerin Maryvonne , Gratier Pierre , Orkisz Jan H. , Guzman Viviana , Bardeau Sébastien , Goicoechea Javier R. , Liszt Harvey , Öberg Karin , Peretto Nicolas , Sievers Albrecht , Tremblin Pascal
Published: October 2017

Context.Previous attempts at segmenting molecular line maps of molecular clouds have focused on using position-position-velocity data cubes of a single molecular line to separate the spatial components of the cloud. In contrast, wide field spectral imaging over a large spectral bandwidth in the (sub)mm domain now allows one to combine multiple molecular tracers to understand the different physical and chemical phases that constitute giant molecular clouds (GMCs).

Aims.We aim at using multiple tracers (sensitive to different physical processes and conditions) to segment a molecular cloud into physically/chemically similar regions (rather than spatially connected components), thus disentangling the different physical/chemical phases present in the cloud.

Methods.We use a machine learning clustering method, namely the Meanshift algorithm, to cluster pixels with similar molecular emission, ignoring spatial information. Clusters are defined around each maximum of the multidimensional probability density function (PDF) of the line integrated intensities. Simple radiative transfer models were used to interpret the astrophysical information uncovered by the clustering analysis.

Results.A clustering analysis based only on theJ= 1–0 lines of three isotopologues of CO proves sufficient to reveal distinct density/column density regimes (nH~ 100 cm-3, ~500 cm-3, and >1000 cm-3), closely related to the usual definitions of diffuse, translucent and high-column-density regions. Adding two UV-sensitive tracers, theJ= 1–0 line of HCO+and theN= 1–0 line of CN, allows us to distinguish two clearly distinct chemical regimes, characteristic of UV-illuminated and UV-shielded gas. The UV-illuminated regime shows overbright HCO+and CN emission, which we relate to a photochemical enrichment effect. We also find a tail of high CN/HCO+intensity ratio in UV-illuminated regions. Finer distinctions in density classes (nH~ 7 × 103cm-3, ~4 × 104cm-3) for the densest regions are also identified, likely related to the higher critical density of the CN and HCO+(1–0) lines. These distinctions are only possible because the high-density regions are spatially resolved.

Conclusions.Molecules are versatile tracers of GMCs because their line intensities bear the signature of the physics and chemistry at play in the gas. The association of simultaneous multi-line, wide-field mapping and powerful machine learning methods such as the Meanshift clustering algorithm reveals how to decode the complex information available in these molecular tracers.
Optimal design of sales and maintenance under the renewable warranty
Authors: Jiao Can , Zhu Xiaoyan
Published: October 2017

This paper presents an integrated model to determine the optimal sales price, preventive maintenance (PM) interval and warranty period with the objective of maximizing the total profit. It is assumed that the sales growth can be featured by NHPP-Bass model over the time. Production cost, R&D cost and warranty cost involving product reliability are considered in this integrated profit model. Then, we consider a periodic PM policy, minimal repair and replacement policy in this paper and the product is deteriorated with the time goes. We also consider effects of the repair time of the repairable product. During the warranty period, manufacturer conducts the PM periodically, and if the repair time is beyond the limited repair time, the failure is replaced with a new product attached renewed warranty period. If not, the failed product is conducted with only minimal repair. Moreover, we give the numerical example and the sensitive analysis to provide insights into the influence of sales price, warranty period and PM interval.
The analysis of discrete time Geom/Geom/1 queue with single working vacation and multiple vacations (Geom/Geom/1/SWV+MV)
Authors: Ye Qingqing , Liu Liwei
Published: October 2017

In this article, we consider a discrete-time Geom/Geom/1 queue with two phase vacation policy that comprises single working vacation and multiple vacations, denoted by Geom/Geom/1/SWV+MV. For this model, we first derive the explicit expression for the stationary system size by the matrix-geometric solution method. Next, we obtain the stochastic decomposition structures of system size and the sojourn time of an arbitrary customer in steady state. Moreover, the regular busy period and busy cycle are analyzed by limiting theorem of alternative renewal process. Besides, some special cases are presented and the relationship between the Geom/Geom/1/SWV+MV queue and its continuous time counterpart is investigated. Finally, we perform several experiments to illustrate the effect of model parameters on some performance measures.
Portopulmonary Hypertension
Authors: Watherald Jason , Sitbon Olivier , Savale Laurent
Published: October 2017

Portal hypertension may have major consequences on the pulmonary vasculature due to complex pathophysiological interactions between liver and lungs. Portopulmonary hypertension (PoPH) is characterized by the association of portal hypertension and pulmonary arterial hypertension (PAH). As progressive elevation of right ventricular afterload can lead to right heart failure, PoPH is a serious complication of portal hypertension, affecting functional status and prognosis of patients. Early detection by transthoracic echocardiography must be performed in symptomatic patients and in candidates for liver transplantation (LT). Right heart catheterization remains mandatory to confirm the diagnosis and exclude all other causes of elevated pulmonary pressures. The management of PoPH includes PAH-targeted therapies although few studies have evaluated these medications in this specific indication. The impact of LT on PoPH outcome remains complex and must be specified by future collaborative investigation. Although uncontrolled PoPH is associated with higher risk of postoperative right heart failure and death, stabilization, improvement, or normalization of pulmonary hemodynamics after LT seem to be achievable goals in selected patients with PoPH.
Update on Data Reuse in Health Care
Authors: Safran C.
Published: October 2017

Objective: Reuse of clinical data has broad use in clinical, research, governmental, and business settings. This summary provides an update on the benefits, barriers to use with large clinical databases, policy frameworks that have been formulated, and challenges.

Methods: This report highlights some recent publications on the diverse uses of clinical data and some policy initiatives to promote reuse. It also contains the opinions of the author.

Results: Although many examples of the benefits of data reuse have been documented, this summary also reviews why the quality of clinical data needs to be the focus of future informatics work.

Conclusion: The promise of reusing data outweighs potential risks, but concerns about privacy and the need to modernize our legal framework will be necessary to realize the full benefits of real-world evidence.
Surgical Management of Liver Metastases from Colorectal Carcinoma
Authors: Acevedo-Moreno Lou-Anne , Aucejo Federico
Published: October 2017

Colorectal carcinoma continues to be a leading cause in cancer-related mortality with more than 130,000 new cases diagnosed annually in the United States. About 50% of patients will develop colorectal cancer liver metastasis (CRLM). Liver resection continues to be the mainstay therapy in the management of CRLM and is associated with 25 to 60% 5-year survival. Alternative nonsurgical therapies offer modest survival when CRLM is unresectable. Herein, we provide an overview of key aspects of surgical approaches to the treatment of CRLM.
Das diabetische Fußsyndrom
Authors: Struller Florian , Königsrainer Alfred , Beckert Stefan
Published: October 2017

The diabetic foot syndrome (DFS) has a great socio-economic impact due to the increasing prevalence of diabetes mellitus. This disease complex is responsible for most non trauma-related limb amputations. The diabetic foot syndrome is classified into a neuropathic, an ischemic and a mixed type. The main pathogenetic mechanism is sensomotoric neuropathy. A frequently simultaneously existing reduced joint mobility as well as a peripheral arterial occlusive disease (PAD) amplify the common pathogenic pathway.

The symptoms of the patients correspond to those of the sensory neuropathy (tingling paresthesia, burning pain, and hyperaesthesia) and are typically exacerbated at night.

In the course of the diagnostic work-up, risk factors of a diabetic foot syndrome are to be elicited in the patient’s history. Clinical examination can determine the severity of neuropathy as well as the presence of a PAD.

The therapeutic approach is primarily aimed to prevent limb amputation. The main therapeutic actions consist of wound debridement, consequent off-loading, treatment of infection, stage-appropriate local wound care, revascularisation, metabolic control as well as patient education. Treatment should therefore always be carried out in a multidisciplinary setting, with a special role being played by the physician due to regular patient examination.

Reduction of limb amputation rate can only be achieved by adherence to these particular treatment protocols.
Role of the Gut Microbiota in Ischemic Stroke
Authors: Winek Katarzyna , Dirnagl Ulrich , Meisel Andreas
Published: October 2017

Recent studies have provided evidence for the role of the gut microbiota in the homeostasis of the central nervous system (CNS) and in the pathophysiology of its disorders, e. g. by regulation of the peripheral immune response. In this article, we discuss the importance of the gut microbiota in stroke by providing a summary of available clinical and experimental data suggesting that 1) stroke changes the gut microbiome, 2) microbiota modulates stroke outcome and 3) microbiota plays an important role in the pathogenesis of stroke (risk factors). Currently available clinical and experimental evidence suggests an important role of gut microbiota in stroke and promises clinically relevant discoveries within coming years.
Multiple glomus tumours in multidigit nail
bed
Authors: Lee Jun-Ku , Kim Tae-sup , Kim Dong-won , Han Soo-Hong
Published: October 2017

Glomus tumours are lesions of the glomus body. A solitary glomus tumour is a more
common, characteristically painful lesion, frequently located under the nail,
whereas multiple glomus tumours are a rare clinical and genetic entity. Multiple
glomus tumours are rarely subungual and do not show preference for any
particular region of the body. We report a rare case of painful multidigit
subungual glomus tumours in both hands.

A 34-year-old male patient complained of painful fingertips (right: thumb, index
finger, long finger, and ring finger; left: thumb, long finger, ring finger,
small finger) on both hands for more than 5 years. Magnetic resonance imaging
(MRI) detected multiple subungual glomus tumours in the fingertips (right long
finger, ring finger, and left thumb, long, ring, and small finger) of both his
hands, so the authors conducted tumour resection and sent biopsies for relevant
fingers. We found the glomus tumour underneath the nail bed and achieved final
diagnosis with histological confirmation. No remnant or newly developed lesion
was detected at the 1 year outpatient clinic.

Our case differed from the usual multiple glomus tumours because its
characteristics were similar to those of a solitary glomus tumour, including the
classic symptom triad: severe pain, localised pain, and cold hypersensitivity.
In case report, we suggest the possibility that multidigit subungual glomus
tumour is different from the common single subungual glomus tumour.
Pilotstudie über die Wirkung und den Nutzen von autologen
Fettgewebstransplantaten bei Rhizarthrose verglichen mit einer Kortisoninjektion
– 3 Monatsergebnisse
Authors: Haas Elisabeth Maria , Volkmer Elias , Giunta Riccardo E.
Published: October 2017

Zusammenfassung

Hintergrund/Ziel Erste Ergebnisse deuten darauf hin, dass eine
intraartikuläre autologe Fetttransplantation bei Rhiz­arthrose nützlich sein
kann. Diese prospektive, nicht randomisierte Pilotstudie untersucht diese neue
Methode hinsichtlich ihres klinischen Ergebnisses im Vergleich mit einer
intraartikulären Kortikosteroidinjektion.

Patienten und Methoden 17 Frauen und 7 Männer mit einem Durchschnittsalter
von 63,3 (47–75) Jahren mit symptomatischer Rhizarthrose wurden in die Studie
eingeschlossen. Bei 12 Patienten erfolgte nach transumbillikaler Fettabsaugung
von 10 ml Bauchfett unter radiologischer Kontrolle die Injektion von 1–1,5 ml
Fettgewebe in das Daumensattelgelenk. Zuvor wurde das Fett unter Verwendung von
zwei Luer-Lock-Spritzen homogenisiert, jedoch nicht zentrifugiert. Postoperativ
erfolgte eine Ruhigstellung mittels Handgelenksschiene unter Einschluss des
Daumens für 1 Woche. Die Patienten der Kortison-Kontrollgruppe erhielten unter
sterilen Bedingungen eine intraartikuläre Injektion von 10 mg (1 ml)
Triamcinolon®. Es erfolgte keine Ruhigstellung. Präoperativ und 2, 6 und 12
Wochen postoperativ wurden der QuickDASH und der Michigan-Hand-Questionnaire
(MHQ) erhoben, die Schmerzen anhand der visuellen Analogskala (VAS) bestimmt und
Grob- sowie Griffkraft gemessen.

Ergebnisse Sowohl in der Kortison- als auch in der Eigenfett-Gruppe zeigte
sich nach zwei Wochen ein signifikanter Rückgang des Belastungsschmerzes. Beide
Maßnahmen hatten keinen signifikanten Einfluss auf die Kraft. Die Auswertungen
der Lebensqualität mittels QuickDASH und MHQ nach Kortisonbehandlung zeigte
zunächst eine Verbesserung der Lebensqualität, welche allerdings nach der 6.
Woche unter das Vorniveau abfiel. Nach Eigenfetttransplantation kam es zu einer
kontinuierlichen Zunahme der Lebensqualität.

Schlussfolgerung Im Gegensatz zur Therapie mit Kortisoninjektion konnte im
3-Monats-Nachuntersuchungszeitraum eine anhaltende Schmerzreduktion in der
Fettinjektionsgruppe erzielt werden, wohingegen eine Kortisoninjektion nur zu
einer kurzfristigen, im Mittel etwa 6 Wochen anhaltenden Reduktion des Schmerzes
führte. Eine längerfristige Nachuntersuchung muss nun zeigen, wie nachhaltig der
Effekt der autologen Fetttransplantation bei Rhizarthrose ist.