bluuebunny/crossref_metadata_2025 huggingface dataset:
Glosa do uchwały SN z dnia 13 kwietnia 2022 roku, sygn. III CZP 76/22
Authors: Rzewuska Magdalena
Published: March 2023

Przedmiotem opracowania jest analiza uchwały Sądu Najwyższego z dnia 13 kwietnia 2022 roku o sygnaturze III CZP 76/22, w której sąd za dopuszczalne uznał zagrożenie „osobie uprawnionej do kontaktów z dzieckiem nakazaniem zapłaty określonej sumy pieniężnej na rzecz osoby, pod której pieczą dziecko pozostaje, za ich niezrealizowanie (art. 59815 § 2 k.p.c.) także wtedy, gdy w ugodzie użyto określenia, że uprawniony ma prawo do kontaktów z dzieckiem, a pominięto będący odpowiednikiem prawa obowiązek realizowania uzgodnionych kontaktów”. Autorka pozytywnie ustosunkowała się do stanowiska SN wyrażonego w przywołanej uchwale oraz przedstawiła argumenty przemawiające za trafnością tezy sformułowanej przez sąd.
Prawo socjalne w niemieckiej i polskiej doktrynie prawa
Authors: Simińska Anna
Published: March 2023

Prawo socjalne w niemieckim porządku prawnym jest osobną dziedziną prawa (Rechtsgebiet), wyróżniającą się w swej specyfice i podstawowej strukturze. To system niezwykle rozbudowany, którego początków należy upatrywać w reformach społecznych czasów wilhelmińskich. Tymczasem w polskiej doktrynie prawa i piśmiennictwie prawniczym kategoria prawa socjalnego nie ma tak długiej tradycji. Prawo określające socjalną pozycję obywatela polska nauka odnosi raczej do realizacji „polityki społecznej”. Współcześnie w polskim dorobku naukowym widoczne są jednak liczne inspiracje niemiecką doktryną prawa socjalnego i co za tym idzie podejmowane są próby wyznaczenia desygnatów prawa socjalnego w polskiej doktrynie prawa.
Prawo mniejszości narodowych do uczestnictwa w życiu publicznym państwa zamieszkania
Authors: Wereszko Wojciech
Published: March 2023

W szanującym prawa człowieka demokratycznym państwie każdy obywatel ma prawo do uczestnictwa w życiu publicznym — dysponuje czynnym i biernym prawem wyborczym, ma dostęp do służby publicznej i co do zasady może uczestniczyć w kierowaniu sprawami publicznymi. Niektóre regulacje i dokumenty międzynarodowe formułują również w tym zakresie specjalne prawo mniejszości narodowych czy też osób do nich należących. Dla tych podatnych na marginalizację grup szczególnie ważne jest bowiem, także w kontekście korzystania z innych praw, zapewnienie im przez państwo możliwości efektywnego udziału w życiu publicznym, partycypacji we władzy i zabierania głosu w dotyczących ich sprawach. Realizacja tego prawa może jednak następować w różnych formach prawnych i prawnoustrojowych. W związku z tym warto poddać analizie regulacje przywołujące prawo mniejszości narodowych do uczestnictwa w życiu publicznym i tym samym odkryć charakter tego prawa oraz potencjalne formy jego urzeczywistniania przez państwa.
CLIMATE CRISIS AS A CATALYST TO ADVANCE INDIGENOUS RIGHTS
Authors:   University of Waikato, Gray Nathan , Athy Ariana ,   University of Waikato, Milfont Taciano ,   University of Waikato
Published: March 2023

Climate change is the most grievous threat of the 21st century and disproportionately affects politically marginalised communities such as Indigenous peoples. As custodians of approximately 80% of the planet’s biodiversity, Indigenous cultures have practised sustainable management of ecosystems and resources over millennia providing vital pathways for humanity to better mitigate accelerating climate change impacts. This article argues that a rights-based approach is an important legal avenue to help better protect and advance Indigenous peoples’ rights and the biodiversity in their regions. The challenge is to develop a framework that incorporates Indigenous rights into international human rights law while obtaining judicial buy-in by domestic legal systems and nations. Drawing from international legal instruments to better protect and bolster Indigenous rights, and using Aotearoa New Zealand as a case study, this paper identifies how rights of Indigenous communities can be enhanced while serving the global goals of climate change mitigation and adaptation.
World Economy Perspectives for 2023
Authors: Almerco Palomino José Luis
Published: March 2023

The world economy presents an abrupt and prolonged slowdown that will affect low- and middle-income countries more strongly. According to the World Bank (2023), the projected growth forecast for the economy for 2023 dropped, from July 2022 to January 2023, from 3% at 1.7%.
Commodity Medium-Term Cycles and Transition to Green Energies: A Markov Switching Model
Authors: Velita-Zorrilla Raúl Alexander , Álvarez García Kevin Antonio
Published: March 2023

This study uses an AR model with Markov Switching approach to forecast the real growth of copper price using 2 regimes: expansion and contraction. We expect an increase in the demand for metals in the medium term due to the transition to green energies. In the estimated model, we see that the contractive state presents a negative growth, while the expansionary state shows a growth equal to 3.57 percent annually. The filtered and smoothed probabilities show that the real growth of copper is in the expansionary state most of the time (approximately the 82.56 percent of the time of the sample period). Thus, we provide evidence that in the medium-run term (next 20 years), it is expected that the real price of copper grows at the same rate as the expansionary state of its previous medium-run term cycle, which is equal to 3.57 percent annually.
Investigating the Effects of Feeding Two Sources of Omega-3 on Feed Intake, Digestibility, and Blood Metabolites of Horses
Authors: Ghaem Maghami Farahani Hamid , Dehghan-Banadaky Mehdi , Paknia Elham , Mahdavi-Zafarghandi Valiollah
Published: March 2023

To investigate the impacts of various sources of omega-3 on feed intake, digestibility, and blood metabolites in horses, this research was conducted. In this survey, 6 medium-sized Turkmen horses, aged 14 to 16 years, were used. The horses had no movement and health problems. This research was carried out in the form of a rotating design and included 3 periods, and each treatment had 2 repetitions in each period. In each experimental period, horses were randomly assigned to each of the 3 experimental treatments. The experimental treatments included C) Omega-3-free supplement (control treatment), R) Persialin flaxseed oil, and P) Persialin fat powder. At the beginning of each period, after the withdrawal period for the previous period, blood and feces samples were taken as the covariate factors, then the experimental treatments were consumed for 14 days, and after the adaptation to 100 grams of supplementing fat powder or flax seed oil, blood, and feces samples were taken at the end of the course. Fat supplements were added to the concentrate 1.5 hours before feeding the midday hay. The palatability was affected by the P treatment and was significantly lower than the R and C groups (P<0.05). But the difference between the two treatments (R and C) was insignificant in any of the periods. The digestibility of acid detergent insoluble fiber (ADF), crude protein (CP), ether extract (EE), and organic matter were not affected by any of the experimental treatments. Blood metabolites including glucose, cholesterol, triglyceride, total protein, and blood urea nitrogen were not influenced by experimental treatments. The serum albumin concentration of horses was affected by the R treatment in the first and third periods, but no significant difference was observed between the treatments in the second period.
A Comparison of Shell Theories for Vibration Analysis of Single-Walled Carbon Nanotubes Based on an Anisotropic Elastic Shell Model
Authors: Strozzi Matteo , Elishakoff Isaac E. , Bochicchio Michele , Cocconcelli Marco , Rubini Riccardo , Radi Enrico
Published: March 2023

In the present paper, the comparison is conducted between three classical shell theories as applied to the linear vibrations of single-walled carbon nanotubes (SWCNTs); specifically, the evaluation of the natural frequencies is conducted via Donnell, Sanders and Flügge shell theories. The actual discrete SWCNT is modelled by means of a continuous homogeneous cylindrical shell considering equivalent thickness and surface density. In order to take into account the intrinsic chirality of carbon nanotubes (CNTs), a molecular based anisotropic elastic shell model is considered. Simply supported boundary conditions are imposed and complex method is applied to solve the equations of motion and to obtain the natural frequencies. Comparisons with the results of molecular dynamics simulations available in literature are performed to check the accuracy of the three different shell theories, where Flügge shell theory is found to be the most accurate. Then, a parametric analysis evaluating the effect of diameter, aspect ratio and number of waves along the longitudinal and circumferential directions on the natural frequencies of SWCNTs is performed in the framework of the three different shell theories. Assuming the results of Flügge shell theory as references, it is obtained that Donnell shell theory is not accurate for relatively low longitudinal and circumferential wavenumbers, for relatively low diameters and for relatively high aspect ratios. On the other hand, it is obtained that Sanders shell theory is very accurate for all the considered geometries and wavenumbers, and therefore it can be correctly adopted instead of the more complex Flügge shell theory for the vibration modelling of SWCNTs.
Sintesis Carbon Nanofoam dan Karakteristiknya
Authors: Muchlisha Nuryah , Widjonarko Dian Maruto , Saraswati Teguh Endah
Published: March 2023

Karbon memiliki kemampuan untuk membuat jaringan ikatan hibridisasi sp, sp‒sp2, sp2, sp3, dan sp2‒sp3,sehingga karbon terdapat dalam banyak bentuk alotrop seperti grafit, diamond, graphene, nanofiber, nanofoam, dan nanotube. Carbon nanofoam (CNF) terbentuk dari atom karbon yang terikat secara sp2 dan sp3. CNF memiliki struktur sel terbuka yang saling berhubungan, densitas yang sangat rendah, stabilitas termal yang tinggi, dan porositas yang tinggi. CNF dapat diperoleh dengan menggunakan berbagai metode seperti chemical vapor depositon, laser ablsasi, arc-discharge, dan pirolisis. Sintesis dengan berbagai jenis sumber karbon dan keadaan eksperimen menghasilkan material yang memiliki berbagai ukuran, luas permukaan, dan strukturnya. Struktur CNF terdiri dari dua jenis berdasarkan pola tepi strukturnya yaitu zigzag dan armchair. Hasil karakterisasinya menunjukkan bahwa CNF lebih banyak mengandung karbon dengan hibridisasi sp2 dengan struktur yang berinterkoneksi satu sama lain dan memiliki densitas yang sangat rendah. Selain itu, material ini juga memiliki pori dalam ukuran mesopori dan luas permukaan yang tinggi. Sifat unik yang dimiliki oleh CNF berpotensi diaplikasikan dalam berbagai bidang seperti filter, superkapasitor, dan energy storage. 

Synthesis of Carbon Nanofoam and Its Characteristics. Carbon can create sp, sp‒sp2, sp2, sp3, and sp2‒sp3 hybridized bond networks, which make carbon in many allotropes forms such as graphite, diamond, graphene, nanofiber, nanofoam, and nanotubes. Carbon nanofoam  (CNF) is formed by sp2 and sp3 bonded carbon atoms. CNF has an interconnected open-cell structure, very low density, high thermal stability, and high porosity. CNF is obtained using several methods, such as laser ablation, arc-discharge, chemical vapor deposition, and pyrolysis. Synthesis with various types of carbon sources and experimental conditions resulted in materials having various sizes, surface areas, and structures. The structure of CNF consists of two edge pattern types, including zigzag and armchair. The characterization results show that CNF contains more interconnected carbon with sp2 hybridization and has a very low density. In addition, this material also has pores in the mesoporous size and high surface area. The unique properties of CNF provide potential applications in various fields, such as filters, supercapacitors, and energy storage.
The Effect of the "Marbel Reading" Educational Game Application on the Beginning Reading Ability of Students in Islamic Elementary School
Authors: Damayanti Clarinza Fiorentine , Wachidah Kemil
Published: March 2023

Marbel Reading Educational Game Application is an application that aims to help its users learn while playing. This study aims to determine how the influence of the "Marbel Reading" Game Application on the Beginning Reading Ability of Grade 1 Students. This type of research is a quantitative research with a pre-experimental research method One Group Pretest-Postest using all first grade students of SD Islam Nurul Hikam Banjarbendo. consisting of 20 students. Sampling with non-probability techniques. The research instrument used was in the form of multiple choice test questions regarding early reading skills. Data analysis using normality test, t-test, and eta square test. Based on the results of the pretest-posttest get an average value of 31.80. The minimum score is 55.7. The maximum score is 87.5, the statistical standard deviation is 12,547, and the standard deviation error is 2.806. The results of the paired sample t-test concluded that the value was 0.000, meaning the value of sig <0.05, then there was an effect of variable X on variable Y. Then the eta-square test concluded that the value was 0.244, which means the value of sig t 0.14 means that there is a big influence. It is hoped that the results of this study can have a positive impact on its users. The use of the Marbel Reading application is suitable for low grade students to help maximize their early reading skills.
Diseño de un software para la optimización de los procesos administrativos para la mejora de la atención al ciudadano en la Municipalidad Provincial de Pampas en el año 2019
Authors:   , Guadalupe Pacheco Amilkar Randdy
Published: March 2023

La atención al ciudadano en la Municipalidad ubicada en el distrito de Pampas, Provincia de Tayacaja, en el departamento de Huancavelica; que se puede definir como un protocolo importante, ya sea en una empresa o en cualquier tienda de negocio, donde los clientes se sientan muy cómodos con todos sus procesos que realizan, y que sean atendidos lo más rápido posible, ya que todos los documentos que se tramita en una municipalidad son muy importantes para algún otro proceso que esté realizando el cliente. La característica principal de este protocolo de atención es un mala atención y procesos innecesarios para realizar un trámite en la Municipalidad de Pampas debido a se tiene un mal sistema de atención y un mal protocolo de servicio. La cantidad de ciudadanos que se atienden en esta municipalidad, debido a que esta es la sede de varios distritos de Tayacaja, en el tema educativo, administrativo y laboral. Se entiende por esto que la municipalidad maneja diferentes temas de casi toda una provincia, debido a que es en la única municipalidad que se ha invertido mucho más, pero en casos especiales no cuenta con algunos procesos, entonces se realiza una transferencia a Huancavelica. La mala atención lo viven los ciudadanos que realizan todos sus trámites que necesitan para presentarlo en alguna entrevista u organización de trabajo. La problemática generó una mala atención en la Municipalidad de Pampas y desde cuando expone esto a los ciudadanos. Esto permitió identificar todas las molestias e incomodidades que experimentan los ciudadanos al momento de realizar un trámite. Por otra parte, profundizar las causas que ocasiona este problema en la Municipalidad, para tomar diferentes perspectivas, ya sea en el proceso interno de la Municipalidad y externo por parte de los ciudadanos.
Efectividad de manejo convencional y ecológico de la broca del café (Hypothenemus hampei)
Authors:   , Rivera Vilca Mariela de los Ángeles , Diaz Osorio Homar Rómulo
Published: March 2023

El café es el producto más comercializado en todo el mundo y representa la principal fuente de ingresos de familias productoras. Sin embargo, el cultivo de café es afectado por la broca Hypothenemus hampei, el cual disminuye el rendimiento, producción y calidad del cultivo de café. Este trabajo tiene como objetivo determinar la estrategia de control más efectiva para el manejo de la broca. Para ello se realizó una revisión de literatura científica sobre la broca, mediante la base de datos SCOPUS. El procedimiento de búsqueda dio lugar a 399 documentos y solo se consideraron 33 artículos para la revisión sistemática, ya que se aplicó ciertos criterios de inclusión y exclusión. La mayoría de artículos abarcaron estrategias para un manejo ecológico, siendo el manejo biológico el más efectivo por el alto porcentaje de mortandad obtenido en campo.
RPA para la automatización de la gestión administrativa en el área de finanzas de Seidor
Authors:   , Balladares Montalvan Carlos Antonio , Godoy Galdos Miguel Angel , Salinas Gonzales Maicol Yordan
Published: March 2023

La automatización robótica de procesos (RPA) puede considerarse un cambio tan grande como lo fue Internet en el año de 1994. Es muy difícil que alguien haya podido prever lo grande que llegará a ser. Haciendo una mirada rápida en el pasado, lo que nosotros conocíamos como outsourcing mira a lo que es la automatización de procesos robóticos. El trabajo en el futuro será completamente diferente. En pocas palabras, siempre existirá el trabajo, solo que de una manera diferente a lo que conocemos como trabajo en sí. Si nos proyectamos hacia un futuro cercano, con la premisa de tener en nuestra mente al RPA, podemos darnos una idea de qué tipo de habilidades, educación y dominios serán parte innata en nuestros niños preparándose para lo que es inevitable. La automatización de procesos robóticos llegó para quedarse. En lo que concierne a RPA, existe una infinidad de posibilidades en el sector financiero, siendo más específicos en la gestión administrativa del área de finanzas de las organizaciones. En la mayoría de ellas, el enfoque al que se apunta es el de simplificar, estandarizar, cumplir y desagregar dando paso a la minimización de costos mejorando la transparencia. Hay un nuevo foco sobre la mejora de los procesos financieros, la estandarización de los sistemas de TI y el comportamiento humano mejorando y estandarizando el proceso, mezclando los elementos humanos y de automatización. El mejoramiento de procesos de negocio y la experiencia en la transformación financiera juegan un rol fundamental en este cambio. Herbert, Dhayalan y Scott en el 2016 predijeron el crecimiento constante de RPA afirmando que los contadores se centraran en darle valor añadido a su profesión dejando de lado los encargos reiterativos de procesamiento de números.
Importación de laptops hechas con partes de bambú de Taiwan
Authors:   , Reyes Torres Cecilia , Muñoz Guardia Diego Armando
Published: March 2023

En la actualidad la globalización ha formado parte fundamental en el desarrollo de la tecnología y con ello la implementación de aparatos electrónicos como laptops portátiles. “Aceleraron una transición hacia el aprovechamiento de las tecnologías de la información y la comunicación para las labores habituales”. (COMEX PERÚ, 2020) Este año ha sido uno de lo más rentables para la industria tecnológica y esto se debe al contexto vivido por el Covid -19 que generó que muchas empresas optaron por el trabajo remoto para sus colaboradores y las instituciones educativas y universidades decidan que sus estudiantes realicen clases virtuales para evitar el confinamiento y el incremento de contagios de la enfermedad. El Perú ha incrementado el número de importación de laptops. Según Comex Perú “Si se considera que estas importaciones complementan a las primeras, ello evidenciaría, a su vez, el incremento en el acceso y la intensidad de uso de productos relacionados con las tecnologías de la información y comunicación (TIC) en los hogares”. (COMEX PERÚ, 2020) El presente proyecto tiene como finalidad realizar un plan de negocios de importación de laptops hechas con partes de bambú un material eco amigable y biodegradable. Como parte del trabajo se estructura los siguientes puntos que son fundamentales para hacer factible el proyecto…
Evaluación de los impactos del turismo educativo en los Pantanos de Villa y propuesta para mejorar sus efectos en favor del Área Natural Protegida
Authors:   , Flores Parihuamán Ashly Abigail
Published: March 2023

Con esta investigación identificamos posibles efectos del turismo educativo en Los Pantanos de Villa. En este estudio se determinaron los posibles efectos sobre la dimensión ambiental, social y económica. Estos efectos fueron identificados a partir de informes técnicos elaborados por el área protegida. Estos efectos contrastaron con las respuestas obtenidas por las entrevistas con el personal de Prohvilla y Sernanp, aunque otros profesionales vinculados con esta área protegida. Debido a la situación de Covid 19, tuve que usar plataformas virtuales para hacer las entrevistas. La metodología que utilicé en esta investigación incluyó análisis cualitativo con un diseño descriptivo y exploratorio. En este estudio, muestro los principales resultados de la percepción del personal de Pantanos de Villa, quienes confirmaron que el turismo educativo generaría impactos reales en el área protegida. Según mis resultados, los impactos positivos significativos generados por el turismo educativo en Pantanos de Villa fueron ingresos monetarios y promoción. Por otro lado, los impactos negativos identificados fueron: desechos domésticos y daño local a la cobertura vegetal.
Estadíos, proporción sexual y talla de captura Hippocampus ingens (Girard 1859) (Syngnathiformes: Syngnathidae) a partir de una muestra incautada en Perú
Authors:   , Chipana Robles Satchell Hazel
Published: March 2023

Se analizaron 322 individuos de Hippocampus ingens “Caballito de mar del Pacífico” de una muestra deshidratada, proveniente de un decomiso de pesca ilegal realizado en Tumbes, Piura y Lambayeque (región norte del Perú) en el año 2016. Se determinaron los valores de talla de captura, proporción sexual y estadios de desarrollo (juvenil o adulto). El análisis morfométrico consistió en determinar la altura total, altura del cuerpo y largo de la cabeza, mientras que la identificación de sexos se basó en caracteres, morfológicos, tales como, la presencia del saco de incubación y quillas leves para machos, asimismo, en el caso de hembras adultas se consideró la mancha oscura debajo de la aleta anal. Las tallas de captura (altura total) fluctuaron entre 87 mm y 160 mm, correspondiente a individuos adultos. No se encontró diferencia significativa al comparar los valores de la altura total en relación con el sexo de los individuos. La proporción de sexos (hembras:machos) fue de 1.21:1. Los resultados obtenidos resultan útiles para la actualización del estado de una población de H. ingens en el norte del Perú y pueden servir de base para el desarrollo de programas de conservación y futuro manejo pesquero de esta especie en Perú.
Performance Analysis of ECC Using RK and GT Method for Aadhaar Card
Authors: Lizy Felista Sugirtha , Raj Joseph
Published: March 2023

In the Aadhaar Card, security is a major issue. As the data once to be kept as private as possible, we will require some data-handling strategies. This document would be useful for data security. The advantage of this technique is in terms of text encryption and decryption security. Asymmetric algorithms include RSA (Rivest, Adi Shamir, and Leonard Adleman) and ECC (Elliptic Curve Cryptography). The cryptographic algorithms RSA and ECC are used to create a pair of keys, a public key, and a private key. The performances of the RK (Runge-Kutta) algorithm with ECC and the GT (Game Theory) with ECC method are compared in this study. Combining the ECC Method and the RK with GT Method improves the speed and security of this paper. The Avalanche Effect, Speed, Throughput, and Power Consumption of the RK-GT-ECC algorithm is recommended to be improved. The experimental findings of the RK-GT-ECC algorithm show increased performance. There is also a detailed mathematical justification for the use of the RK-GT-ECC algorithm. The improved performance of the RK-GT-ECC approaches, as well as experimental findings, are discussed.
Adapting group-based postpartum and well-child care using a human-centered design approach in Malawi
Authors: Gresh Ashley , Batchelder Anne , Glass Nancy , Mambulasa Janet , Kapito Esnath , MacDonald Amy , Ngutwa Nellie , Plesko Cori , Chirwa Ellen , Patil Crystal
Published: March 2023

Background. Responsive and resilient strategies to reduce the high rates of maternal and infant mortality and clinician shortages are needed in low- and middle-income countries (LMICs). Malawi has some of highest maternal and infant mortality rates globally. Group-based healthcare is one such strategy to improve maternal and child health outcomes. Group-based care has been applied to the perinatal period, but less attention has been paid its potential benefits in postpartum care. The postpartum period is a period of opportunity for innovative approaches to engage mothers and children in care and contribute to the reduction of maternal and infant mortality and morbidity. We present the adaption of an evidence-based group-based perinatal care model to the postpartum period using human centered design with key stakeholders in Malawi.
Methods. To adapt the perinatal group-based care model for the Malawian context, the team completed four steps of a five-step framework guiding the use of human centered design: 1) define the problem and assemble a team; 2) gather information through evidence and inspiration; 3) synthesize; and 4) intervention design: guiding principles and ideation. Steps 2-4 relied on qualitative methods, in-depth interviews, and incubator sessions with key stakeholders to produce a prototype of the group-based postpartum care model.
Results Once the stakeholders had defined the problem of limited postpartum care in the context and assembled local and global team members, we completed 20 interviews and 6 incubator sessions with stakeholders. All stakeholders reported a desire to participate in and offer group care in the postpartum period in their community. Health promotion priorities identified were hygiene (e.g., perineal care), breastfeeding, family planning, nutrition, and mental health. The recommended group-based care implementation schedule includes 6 sessions that corresponds with the child vaccination schedule over the 12-month postpartum period. A prototype for the curriculum and implementation structure for group postpartum and well-child care was created based on the findings.
Conclusions A human centered design approach to adapt an evidence-based group-based care approach to an LMIC, Malawi is feasible and acceptable to key stakeholders and resulted in a prototype curriculum with practical strategies for implementation in the health care setting.
Semi-supervised consistency regularization for accurate cell type fraction and gene expression estimation
Authors: Khatri Robin , Machart Pierre , Bonn Stefan
Published: March 2023

Cell deconvolution is the estimation of cell type fractions and cell type-specific gene expression from mixed data with unknown composition. In biomedical research, cell deconvolution, which is a source separation task, is used to obtain mechanistic and diagnostic insights into human disease. An unmet challenge in cell deconvolution, however, is the scarcity of realistic training data and the strong domain shift observed in synthetic training data that is used in contemporary methods. Here, we hypothesize that simultaneous consistency regularization of the target and training domains will improve deconvolution performance. By adding this novel biologically motivated consistency loss to two deep learning-based deconvolution algorithms, we achieve state-of-the-art performance on both cell fraction and gene expression estimation. Our method, DISSECT, outperforms competing algorithms across several gene expression datasets and can be easily adapted to deconvolve other biomedical data types, as exemplified by our spatial expression deconvolution experiments.
GERD symptoms often improve after magnetic sphincter augmentation (MSA) device removal – an observational study
Authors: Buniak Nicholas , Buniak Borys , Maini Atul , Sivakumar Balasubramanian , Sun John , Jantsch Stacey , Obrien Danielle L. , Frey Tara
Published: March 2023

Hypothesis: Magnetic Sphincter Augmentation device causes fibrosis at the distal esophagus which prevents reflux even after device removal
Background: Gastroesophageal reflux disease (GERD) affects over 20 million people in the United States. If left untreated, chronic reflux of gastric contents into the distal esophagus may result in benign or malignant esophageal strictures, causing varying degrees of dysphagia. We currently offer interventions which artificially create a narrowing at the distal esophagus to prevent complications of GERD. Magnetic Sphincter Augmentation device (MSA), or LINX, creates such a narrowing of the distal esophagus at the level of the LES. Individuals intolerant of this device need surgical removal which leaves scarring at the site of implantation.
Methods: There were 118 MSA devices placed at our institution between 2017 and 2021. During this time, 8 out of 118 (6.7%) patients needed to have their LINX removed due to side effects attributed to the implant. Causes for removal included esophageal perforation, dysphagia or hypersensitivity related chest pressure presumably caused by the device. Patients, who have had the LINX device removed, were followed for recurrence of reflux using Barium Swallow imaging, endoscopic findings and GERD-HRQL scores.
Results: The longer the MSA implants remained before removal, the more extensive the scar tissue encountered at site of excision. Five of eight patients (62%) experienced improvement in their GERD-HRQL scores after removal of the MSA device when compared to results before LINX implantation. The residual band of scar tissue observed after device removal appeared to control reflux by restricting the relaxation of the esophageal outlet.
Conclusions: These results indicate that fibrosis at the site of MSA device removal improves heartburn symptoms in a majority of patients. We do not recommend fundoplication at time of LINX removal as symptoms of GERD may be adequately controlled by scar tissue at the LES.
Deployment Method of Wireless Sensor Networks based on MaOEA/P-GM Algorithm
Authors: Wang Jun , Luo Dongxu , Chen Weiru , Peng Funan , Li Zhiwu
Published: March 2023

At present, wireless sensor networks are developing rapidly, but they will also face many challenges. In the deployment problem, many problems such as cost, coverage, connectivity, energy, network life cycle and so on need to be considered, while the traditional multi-objective algorithm does not perform well in dealing with many-objective problems. How to quickly find high-quality solutions is the focus of research today. This paper proposes a deployment method for wireless sensor networks based on a many-objective evolutionary algorithm with guided mutation. This method improves the mutation strategy of the algorithm according to the characteristics of wireless sensor network deployment based on a many-objective evolutionary algorithm based on the projection plane. Experiments show that using this algorithm in a many-objective environment can quickly get a high-quality solution set with fewer nodes, high coverage, good connectivity and balanced energy consumption.
Comparison of cerebral hemodynamics among hemodynamically stable preterm (28 0/6- 34 6/7 weeks) small for gestational age (SGA) and appropriate for gestational age (AGA) neonates during the first 72 hours of life: A Prospective Cohort Study
Authors: Gupta Priyanka , Oleti Tejo Pratap , Deshabhotla SaiKiran , Vardhelli Venkateshwarlu , Narala Sadhana , Nair Shruthi
Published: March 2023

Background: Transition from fetal to extra uterine circulation is a poorly understood process in terms of cerebral hemodynamics. Postnatal cerebral circulation and autoregulation is affected by the degree of prematurity and fetal hypoxia. Currently, the data on changes in postnatal cerebral blood flow indices in preterm and SGA neonates is limited.
Objective: To investigate the differences between cerebral hemodynamics between preterm (28 0/6- 34 6/7) small for gestational age (SGA) and appropriate for gestational age (AGA) neonates.
Methodology: In this prospective cohort study done in a tertiary care centre of South India in the year 2020-2021, we compared cerebral function parameters as assessed by doppler sonography between hemodynamically stable SGA (n = 57) and AGA neonates (n = 91) admitted to the NICU during the first 72 hours.
Results: Preterm SGA neonates have significantly lower pulsatility index (PI) and resistive index (RI) in middle cerebral artery on day 2 and day 3. On day 2, the median (IQR) PI was 1.05 (0.91-1.98) vs 1.26 (1.10-1.39), p=0.002 and mean ± SD RI of 0.67 ± 0.09 vs 0.71 ± 0.08, p=0.01 and on day 3 median (IQR) PI was 1.12 (1.01-1.32) vs 1.28 (1.10-1.51), p=0.05 and mean ± SD RI of 0.68 ± 0.08 vs 0.72 ± 0.10 (p = 0.01) in SGA and AGA neonates respectively.
Conclusion: SGA neonates have significantly lower indices of cerebral perfusion as seen by low PI and RI in MCA (middle cerebral artery) as compared to their AGA counterparts.
Cognitive Escape Reinforcement Learning for Complex Decision Making
Authors: Wu Qihui , Zhao Shijin , Zhou Fuhui , Zhang Hao , Huang Yang , Ma Kai-Kuang
Published: March 2023

Reinforcement learning is one of the most important methodologies in artificial intelligence and has achieved unprecedented success for addressing the fundamental decision-making tasks in various fields, including financial decisions, navigation, and robotic control tasks. However, the current reinforcement learning faces two well-recognized challenging problems, namely, trapping in the local optima and weak generalization, limiting its ability and performance to tackle complex and dynamic decision making tasks. Here, inspired by human intelligence, we present a new framework, called the \emph{cognitive escape reinforcement learning} (CERL), that has the cognition escape module and the semantic cognition module, for avoiding local optima and achieving strong generalization. Moreover, we elaborate on CERL in a classical and complex decision-making task, namely, visual navigation. Extensive experiments demonstrate the efficacy of our proposed CERL framework. Its navigation performance is also remarkably superior to those of the state-of-the-art methods. Furthermore, it can achieve the highest navigation success rate, which is more than 6\% higher than that of the best agent among the existing ones. The required path length is shortened by more than 29\% and delivers real-time performance. Our presented reinforcement learning-based framework opens up a new direction for tackling future complex decision-making tasks rapidly and with high performance.
A Clustering Algorithm Based on Topological Anomalies Applied to Wireless Body Area Networks
Authors: Ferreira Creyton B. de M. , Reis Thiago B. F. , Tcheou Michel Pompeu , Guedes Raphael Melo , Henriques Felipe da Rocha , de Assis Laura Silva
Published: March 2023

Wireless Body Area Networks (WBANs) are formed by autonomous devices that collect biometric data from the human body. Such devices (sensors) commonly use low transmitting power. Thus, even small postural variations can cause disconnections. Based on this problem, we propose an algorithm for cluster topology generation, based on anomalous topologies. The proposed algorithm determines metrics for the quality and stability of the clusters, based on a recent history of previous clusters. In order to perform a more realistic evaluation of the proposed algorithm, we consider a real-life typical movement pattern. The Omnet++ was considered, and simulation results showed that the proposed algorithm outperformed the LEACH protocol concerning both: i) energy conservation, and ii) packet delivery ratio in a WBAN with mobility.
Effects of soil nutrients and nitrogen application rate of grain fertilizer on yield and grain quality of hybrid medium rice in high temperature and drought area of southern Sichuan, China
Authors: Xu Fuxian , Yuan Chi , Han Dong , Chen Kun , Zeng Shiqing , Zhou Xingbin , Zhang Lin , Jiang Peng , Guo Xiaoyi
Published: March 2023

To provide scientific basis for formulating high-quality and high-yield fertilization techniques for large-scale production of hybrid medium rice in high temperature and drought area of southern Sichuan, China. The effects of basic fertility and grain fertilizer level on Yield and quality of rice were studied by setting grain fertilizer application rates in three years and seven sites. The results showed that: (1) head rice rate, chalkiness rate and chalkiness degree were greatly affected by environment (CV was 28.31% ～58.45%), while length width ratio, gel consistency and amylose content were slightly affected by environment (CV was 2.75% ～6.53%); (2)The differences of yield, head rice rate, length width ratio, chalkiness rate, chalkiness, gel consistency and amylose content among three years and seven sites were extremely significant (F = 3.46 ** ～602.82 **); There was a significant negative correlation between amylose content and nitrogen application rate (r = - 0.3610 ** ～- 0.6065 * *, n = 56).(3) the yield and quality of rice had very significant relationship with location and soil nutrient background (F value 13.98 * ～ 14155.2 **) , the degree of determination was as high as 89.48% ～ 99.99% .(4) the correlation between yield and quality traits was different in different years, and the correlation analysis from 2018 to 2020 showed that yield was negatively correlated with aspect ratio, gel consistency and amylose (r =-0.1898 **～-0.3192 * , n = 210) , and significantly positively correlated with chalkiness rate and chalkiness degree (r = 0.1516 * ～ 0.1661 *). The yield and quality of rice are affected by the interaction of ecological conditions, soil nutrient background values and variety characteristics. Increasing soil available N, K content and controlling P content are beneficial to improving rice quality, with the increase of yield, the quality of rice decreased, and the cultivation way of high-quality and high-yield of hybrid medium rice was put forward.
Use of Antibiotics and Cognitive Function in Older US Adults
Authors: Tesema Naomi , Wroblewski Kristen , McClintock Martha , Pinto Jayant
Published: March 2023

Background
To investigate the relationship between antibiotic use and subsequent cognitive function in older adults. Older adults who use antibiotics will have lower cognitive function over time.
Methods
In this longitudinal study of a representative sample of older U.S. adults (N = 2,939, National Social Life, Health, and Aging Project), we directly recorded antibiotic use during a home interview at baseline. Five years later, cognition and dementia were assessed (modified Montreal Cognitive Assessment [MoCA-SA] and reported physician diagnosis of dementia). Associations were tested using logistic regression, adjusting for age, gender, race/ethnicity, education, comorbidities, other medication use, and baseline cognition (Short Portable Mental Status Questionnaire).
Results
Older US adults who used antibiotics were less likely to score at or above the 85th percentile of MoCA-SA scores 5 years later (OR 0.27, 95% CI 0.13–0.58). There was no statistically significant association between antibiotic use and interval diagnosis of dementia, which was rare in this relatively healthy sample of older adults living at home.
Conclusion
Antibiotic use is associated with worse cognitive function five years later. This epidemiologic evidence is consistent with the effects of a disrupted gut microbiome on brain function or direct effects on the central nervous system.
Lateralized dominance of the nasal cycle is not reflected in the Olfactory Bulb volumes and cerebral activations
Authors: Thaploo Divesh , Joshi Akshita , Thomas Marie , Hummel Thomas
Published: March 2023

Background- Nasal cycle (NC) is a rhythmic change of lateralized nasal airflow mediated by the autonomous nervous system. Previous studies reported the dependence of NC dominance on handedness and hemispheric cerebral activity.
Objective- We aimed to investigate firstly, the possible lateralized effect of NC dominance on olfactory bulb volume: the first cerebral region processing olfactory information, and secondly, the association of NC dominance with the lateralized cerebral dominance in terms of olfactory processing.
Methods- Thirty- five subjects (22 women, mean age 26 ± 3 years) participated in the study. NC dominance was ascertained using a portable rhino-flowmeter, the “Nasal Holter” for a duration of 24 h, out of which 22 subjects had right-dominant NC and 13 subjects had left-sided dominance. Structural and functional brain measurements were assessed using a 3T MR scanner (Siemens). Vanillin odor was presented during functional scans using a computer-controlled olfactometer.
Results and Conclusions- NC dominance was found to be independent of the lateralization of olfactory bulb volumes. Also, cerebral activations were found independent of the NC during odor perception. NC dominance is not associated with lateralized structural or functional differences in the cerebral olfactory system.
Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas
Authors: Castro Francisco José Calero , Eguía Andrés Padillo , Muñoz-Cruzado Virginia Durán , Aguilar Luis Tallón , González José Tinoco , Laga Imán , de Juan Fernando de la Portilla , Ciuró Felipe Pareja , Ruiz Javier Padillo
Published: March 2023

Additive manufacturing techniques allow the customized design of medical devices according to the patient’s requirements. Enteroatmospheric fistula is a pathology that benefits from this personalization due to its extensive clinical variability since the size and morphology of the wound differ extensively among patients. Standard prosthetics do not achieve proper isolation of the wound, leading to a higher risk of infections. Currently, no effective personalized technique to isolate it has been described. In this work, we present the workflow for the design and manufacture of customized devices adapted to the fistula characteristics. For each case, a device was designed with dimensions and morphology depending on each patient’s requirements using white light scanning, CAD design, and additive manufacturing. The design and manufacture of the devices were performed in 230.50 min [184.00, 304.75]. After the placement of the device, the wound was successfully isolated from the intestinal content for 48-72h. Negative Pressure Wound Therapy (NPWT) was applied for 27.71 ± 13.74 days, and the device was redesigned to adapt to the wound when geometrical evolutionary changes occur during the therapy. It was observed a decrease in weekly cures from 23.63 ± 10.54 to 2.69 ± 0.65 (p = 0.001). The fistulose size was reduced longitudinal and transversally by 3.25 ± 2.56 cm and 6.06 ± 3.14 cm respectively. The wound depth also decreased by 1.94 ± 1.08 cm. In conclusion, customization through additive manufacturing is feasible and offers promising results in the generation of personalized devices for the treatment of enteroatmospheric fistula.
A worldwide systematic review of blunt abdominal aortic injury and analysis of predictors for death
Authors: Li Mingxuan , Wang Chaonan , Tu Haixia , Zhu Haitao , Guo Zhen
Published: March 2023

Background Blunt abdominal aortic injury (BAAI) is characterized by diverse clinical manifestations, evaluations, and treatment criteria, while very high mortality. At present, there are few studies on BAAI, and most of them are case reports. Methods By including available case reports world widely, a systematic review regarding the data of BAAI patients in characteristics, treatments, and outcomes was performed. And regression analysis of predictors for death after BAAI was conducted. Results The systematic search of Excerpta Medica Database, PubMed, Web of Science and Cochrane Library resulted in 2,099 hits. There were 102 case reports and 1 conference abstract met the inclusion criteria and were eligible for analysis. After assessment using the Joanna Briggs Institute (JBI) checklist, no low-quality studies were found. Then the data of 133 BAAI patients were concluded and analyzed. The median age of these patients was 34, and there were 98 (73.7%) males. Their most common clinical manifestation was pain (65.6%). The most common severity of aortic lesion was grade A (intimal tear or intramural hematoma) (46.9%), and the most common location of aortic lesion was zone III (infrarenal aorta) (88.3%). The overall mortality after BAAI was 15.3%. On multivariable regression analysis, the risk of death after BAAI was increased in patients with lower limb ischemia [relative risk (RR), 7.137; 95% confidence interval (CI), 1.154–44.161], cardiopulmonary arrest (RR, 10.250; 95% CI, 1.452–72.344), and injuries to other parts (other than abdomen and lumbar spine) of body (RR, 2.593; 95% CI, 1.189–5.655). Then on subgroup analysis, patients with BAAI in the presence of lower limb ischemia or injuries to other parts of body, whether undergoing primary or secondary operation, had lower mortality than those who underwent conservative observation (P < 0.05), but the mortality of BAAI patients who presented with cardiopulmonary arrest would not be affected by different treatment modalities (P = 1.000). Conclusions BAAI is a fatal disease. The above three variables are risk factors for death after BAAI. Operation (in any form) to BAAI patients who have these risk factors may reduce their mortality risks.
Association of urinary phthalate metabolites with estrogen receptor related cancers in American adults: A Nationwide Study 2003-2006
Authors: Li Yifan , Zhou Xianghong , Yang Qiuxiang , Jiang Zhongyuan , Hu Dan , Wang Mingda , Wang Sheng , Wei Qiang , Qiu Shi , Yang Lu
Published: March 2023

Background: Phthalates are chemical substances widely used in human consumer goods. Studies have shown that phthalates exposure can affect the physiological function of estrogen receptor (ER). However, there is no comprehensive discussion on the association between phthalates exposure and ER-related cancer risk.
Objective: We conducted a cross-sectional study of urinary phthalate metabolite concentrations and self-reported ER-related cancers among 3,015 participants from two cycles of the national health and Nutrition Examination Survey (NHANES), 2003-2006.
Methods: Seven compounds of phthalate metabolites were examined as expoure biomarkers. We used multivariate logistic regression to estimate odds ratio (ORs) and 95% confidence intervals (CIs), adjusting for potential confounding factors. The concentration of phthalate metabolites is non-normal distribution, so quantile and log-transformation are used for analysis. Account for urine dilution, the creatinine corrected phthalate concentration was applied in our analysis. In addition, we also conducted sensitivity analysis by gender stratification and trend test to explore whether there is a concentration increase effect, so as to explore the relationship between these seven phthalate metabolites and the risk of ER-related cancers.
Results: We observed a higher prevalence of ER-related cancers in the maximal quantile of MCNP (OR=2.37; 95%Cl=1.01-5.55) in adjusted model. Meanwhile, trend test also confirmed that MCNP had a positive trend with the risk of ER-related cancer (P=0.036). In subgroup analysis, the higher concentration of MCNP, the higher the risk of breast cancer. At the same time, the trend test verified our results: the results are positive (OR=3.68;95%Cl=1.15-11.74) (P=0.014).
Conclusion: We provide the main evidence that urinary phthalate metabolites concentrations are positively correlated with ER-related cancers. The positive relationship between MCNP exposure and breast cancer risk is more obvious in women. Further causal studies are needed to confirm the findings in our analysis and clarify the underlying mechanisms.