bluuebunny/crossref_metadata_2025 huggingface dataset:
Hidradenoma Papilliferum of Vulva Simulating Vulval Carcinoma: A Case Report
Authors: Kumar Naina , Pradeep Immanuel , Mangla Mishu , Roy Subhrajyoti
Published: January 2024

Purpose:

Vulval Hidradenoma papilliferum is a rare benign tumor originating from apocrine
sweat glands. They present as a solid solitary nodule of 1-2 cm on the inner margin of labia majora.
Since they are not commonly encountered, their diagnosis is usually difficult and puzzles with
other conditions such as benign and malignant lesions of the skin, vulva, and perineum. The present
case report highlights one such case of vulval Hidradenoma papilliferum in a postmenopausal woman
diagnosed after a histopathological examination of an excised lesion.

Case Presentation:

A 55-year-old P2L2 postmenopausal woman presented to the Gynecology outpatient
department complaining of itching over the vulval region for 3-4 months. There was no associated
bleeding or discharge per vaginum. On local examination, a single nodular, hypopigmented,
non-tender, ulcerative lesion was seen over the right labia majora of size 1x2 cm. It was solid in consistency.
The lesion was excised and sent for histopathological examination, which revealed a wellcircumscribed
subepithelial tumor composed of delicate, complex branching papillae and glandular
elements lined by columnar epithelial secretory cells and myoepithelial cells suggestive of hidradenoma
papilliferum.

Major Findings:

The diagnosis of hidradenoma papilliferum is usually made on surgical excision
and histopathological evaluation of lesions. Hidradenoma papilliferum is difficult to diagnose clinically
as it mimics other benign and malignant gynecological and cutaneous diseases.

Conclusion:

Hence, hidradenoma papilliferum should be kept as a differential in diagnosing women
with solitary asymptomatic nodules in the anogenital region.
MicroRNAs Targeting Critical Molecular Pathways in Diabetic Cardiomyopathy Emerging Valuable for Therapy
Authors: Mathur Priyanka , Saxena Sharad , Saxena Bhawna , Rani Vibha
Published: January 2024

:

MicroRNAs have emerged as an important regulator of post-transcriptional gene expression
studied extensively in many cancers, fetal development, and cardiovascular diseases.
Their endogenous nature and easy manipulation have made them potential diagnostic and therapeutic
molecules. Diseases with complex pathophysiology such as Diabetic Cardiomyopathy
display symptoms at a late stage when the risk of heart failure has become very high. Therefore,
the utilization of microRNAs as a tool to study pathophysiology and device-sustainable treatments
for DCM could be considered. The present review focuses on the mechanistic insights of
diabetic cardiomyopathy and the potential role of microRNAs.
Inbound and Outbound Tourism in China: A Perspective Article
Authors: Dávid Lóránt Dénes , Archi Youssef El , Zhu Kai , Varga Imre , Benbba Brahim , Csizmadia Norbert
Published: January 2024

The tourism industry in China has undergone significant changes due to globalization, technology, and changing consumer preferences. This perspective article, based on a systematic literature review, examines examines trends, challenges, and opportunities in inbound and outbound tourism in China, focusing on the industry's dynamism. Both inbound and outbound tourism have been negatively impacted by the COVID-19 pandemic, which has prompted new strategies and environmental adaptations. China has changed its priorities within the country to encourage domestic travel and support local firms. The rise in internationalisation and the growing middle class in China have led to an unprecedented rise in outbound travel. Chinese travellers are affecting travel habits and spending all around the world in the tourism sector. Language barriers, cultural differences, and safety concerns are some of the challenges that come with travelling abroad. To reach its full potential, China needs to adapt to the shifting global environment and take into account the specifications and preferences of both inbound and outgoing tourists.
The Analysis of Screws Spacing Effect On The Flexural Strength Of Laminated Wood Beams From Pine Pallets Waste
Authors: Arnandha Yudhi , Pandhini Kadarosi Dyah , Murtopo Ali
Published: January 2024

Pine pallets are often used to design the interior of houses, as opposed to pine waste, which is underutilized due to its reduced strength and limited size. Therefore, this research aims to optimize the use of pine pallet waste by making laminated beams using screw joints and determining the effect of screw spacing on the strong bending of laminated beams. Flexural strength tests of laminated wood beams measuring 5 cm x 5 cm x 76 cm with varying screw spacing of 4 cm, 8 cm, 12 cm, and 16 were used to conduct this research. This is in addition to screw length, head, and body diameters of 5 cm, 8 mm, and 4 mm, respectively. Strong bending testing was carried out at the Structural Laboratory of the Department of Civil Engineering, Faculty of Engineering, Tidar University, Magelang. The test results of consecutive Modulus of Rupture (MOR) had average values of 20.996 MPa, 23.067 MPa, 20.207 MPa, 19.292 MPa. and Modulus of Elasticity (MOE) of 1,352.68 MPa, 1,449.35 MPa, 1,146.76 MPa, and 1,128.90 MPa. The result showed that the use of varying screw spacing has no significant effect on the flexural strength of laminated beams. Furthermore, the laminated pine pallet waste with screws can be used as an alternative to pure wood by paying attention to the proper joint spacing.
The Mechanism of Rainfall-Induced Landslide Around Railway Tracks in Central Java Province, Indonesia
Authors: Octaviarini Ika Sakti , Fathani Teuku Faisal , Hardiyatmo Hary Christady , Amalina Anisa Nur , Erzagian Egy
Published: January 2024

Landslide is one of the most disastrous natural hazards in Indonesia, causing significant fatalities and economic losses. Landslides can be triggered by several factors, such as rainfall, earthquakes, soil conditions, and others, where each landslide event has its own triggering and controlling factors. A progressive landslide occurred on the Central Java railway line which resulted in damage to the double-track railway as a transportation infrastructure. The objective of this paper is to understand the process and triggering factors of the landslide. Information was collected through field investigations and measurements based on drilling results at 3 points, geophysical surveys at 5 lines, and laboratory testing of several soil samples. Geological and geotechnical settings, topography, lithology, hydrogeology, and rainfall data of the area were analyzed. Aerial photographs and other remote sensing data were used to evaluate and discuss the information. Landslides in the study area occurred in stages, starting with the formation of a tension crack, followed by two landslides over five months. The results show that the clay material that dominates the study area is the dominant controlling factor of a landslide, triggered by long-duration, low-intensity rainfall. Rainwater entering through tension cracks increases moisture content, adding load to the slope and triggering landslides. Furthermore, the train's external load on the slope also contributes to the occurrence of landslides. The static and cyclic load of the train causes changes in the slope's pressure balance, generating a force that drives the downslope soil. Further analysis was performed using back analysis method with the limit equilibrium method to enhance understanding of slope stability parameters at the time of slope failure. The analysis was performed considering the rising groundwater level. A factor of safety (FS) value of 0.989 was obtained at the end of the simulation, indicating that the slope had failed.
PERANCANGAN INSTALASI KABEL 20 kV PADA AUXILIARY TRANSFORMER SEBAGAI ALTERNATIF BACK FEEDING PLTGU JAWA 2
Authors: AFRIANDA RIO
Published: January 2024

Dalam rangka mewujudkan program pemerintah 35000 MW dilakukan pembangunan Pusat Listrik Tenaga Gas dan Uap (PLTGU) Jawa 2, kapasitas daya sebesar 800 MW dengan sistem interkoneksi 500 kV yang terletak di daerah PLTGU Tanjung Priok Jakarta Utara. Pada PLTGU Jawa 2 dalam pelaksanannya terdapat beberapa tahapan sebelum dilakukan pengoperasian pembangkit seperti tahapan konstruksi dan pengujian/ komisioning. Dalam pengujian peralatan, kebutuhan listrik menggunakan sumber daya listrik dari jaringan eksisting milik PT PLN atau disebut juga dengan back feeding. Salah satu alternatif back feeding PLTGU Jawa 2 adalah dengan menggunakan sumber daya listrik dari kubikel 20 kV GIS 150 kV Priok Timur Lama, cara ini berpotensi mengalami keterlambatan apabila instalasi penyambungan kabel 20 kV yang menyuplai unit auxiliary transformer tidak dilakukan dengan benar. Kabel 20 kV yang terhubung dengan bushing unit auxiliary transformer akan mengalami stress cable jika nilai bending radius kabel dalam penyambungan kabel 20 kV ke bushing unit auxiliary transformer tidak diperhatikan. Dari kendala tersebut dapat dilakukan kajian mengenai perancangan instalasi penyambungan kabel 20 kV yang menyuplai unit auxiliary transformer. Selain itu, kajian mengenai penentuan jenis kabel 20 kV yang akan digunakan juga diperlukan agar sumber daya listrik dapat tersalurkan ke peralatan yang akan dilakukan pengujian secara optimal. Dengan dilakukan kajian tersebut pelaksanaan back feeding dapat berjalan sesuai jadwal yang telah ditentukan dan kendala saat pelaksanaan pengujian back feeding dapat di antisipasi sebelumnya.
KEANEKARAGAMAN EKTOPARASIT DAN PENGARUHNYA TERHADAP PRODUKTIVITAS TELUR AYAM F2 MAHKOTA ARAB
Authors: Narzassi Angga Bintang , Nizma Nata Dwi Annisa , Tsani Salma Mutiara , Poerwanto Seonarwan Hery , Daryono Budi Setiadi
Published: January 2024

Penelitian ini bertujuan untuk mengetahui jenis ektoparasit yang ditemukan, mengetahui produktivitas telur, serta mempelajari pengaruh ektoparasit terhadap produktivitas telur ayam F2 Mahkota Arab. Tahapan penelitian yang dilakukan yaitu; pemeliharaan ayam, pengambilan data telur, pengambilan sampel ektoparasit, preparasi ektoparasit, dan identiﬁkasi ektoparasit. Analisis data meliputi jumlah ektoparasit per-inang, dominasi jenis ektoparasit, dan jumlah kumulatif telur (9 minggu). Hubungan jumlah ektoparasit dengan telur diuji dengan analisis korelasi Pearson (IBM SPSS Statistic 25) dengan taraf signiﬁkansi 5%. Hasil penelitian menunjukan adanya 3 jenis ektoparasit yaitu Dermanyssus galliane, Menopon gallinae, dan Lipeurus caponis. Rerata jumlah telur ayam F2 Mahkota Arab (43.5 butir) lebih tinggi dari ayam Pelung (20 butir) sebagai salah satu ayam lokal. Hasil analisis korelasi pearson menunjukkan korelasi negatif antara jumlah total ektoparasit pada setiap pengambilan terhadap jumlah telur ayam F2 Mahkota Arab dengan nilai signiﬁkansi sebesar 0,008 (P0,05). The diversity of ectoparasites and its eﬀect  on the egg productivity of F2 Mahkota ArabThis research aimed to identify the types of ectoparasites found, determine the egg productivity, and study the inﬂuence of ectoparasites on the egg productivity of F2 Mahkota Arab chickens. The research stages include chicken maintenance, egg data collection, ectoparasite sampling, ectoparasite preparation, and ectoparasite identiﬁcation. Data analysis covers the number of ectoparasites per host, dominant ectoparasite species, and cumulative egg count over 9 weeks. The relationship between ectoparasites and egg productivity is tested using Pearson correlation analysis (IBM SPSS Statistics 25) with a signiﬁcance level of 5%. The research results show the presence of three ectoparasite species: Dermanyssus galliane, Menopon gallinae, and Lipeurus caponis. The average number of F2 Mahkota Arab chicken eggs (43,5 eggs) is higher than that of Pelung chickens (20 eggs), one of the local chicken breeds. The Pearson correlation analysis indicate a negative correlation between the total number of ectoparasites in each collection and the number of F2 Mahkota Arab chicken eggs, with a signiﬁcance value of 0.008 (P0.05).
Aplikasi variasi jumlah pelat elektroda Al-Fe pada pengurangan mikroplastik dalam limbah masker secara elektrokoagulasi
Authors: Marwati Siti Marwati , Yosephine Louise Isana Supiah , Padmaningrum Regina Tutik , Rahmawati Aprilia , Hamida Zahra , Julia Ardhita
Published: January 2024

Kebijakan untuk mencegah tersebarnya virus Covid-19 melalui kewajiban menggunakan masker menyebabkan jumlah limbah masker medis sekali pakai meningkat secara signifikan. Limbah ini berbahaya karena melepaskan mikroplastik di perairan. Penelitian ini bertujuan untuk mengetahui pengaruh jumlah pelat elektroda Fe-Al pada pengurangan mikroplastik dalam limbah masker secara elektrokoagulasi. Sampel dalam penelitian ini adalah limbah masker medis. Masker dipotong-potong dengan ukuran 1-5 mm. Potongan masker tersebut direndam dalam aquades selama 7 hari. Cairan yang mengandung mikroplastik dielektrokoagulasi dengan kombinasi pelat elektroda (Al-Fe), (Al-Fe-Al), dan (Al-Fe-Al-Fe) selama 4 jam, arus listrik 2,5 A dan pH 6,0. Serat mikroplastik sebelum dan sesudah elektrokoagulasi diamati dengan mikroskop perbesaran 40 kali. Karakterisasi mikroplastik dilakukan dengan menggunakan FTIR (Fourier Transform Infra Red) dan SEM (Scanning Electron Microscope). Hasil penelitian menunjukkan bahwa efektifitas pengurangan mikroplastik yang dielektrokoagulasi menggunakan kombinasi pelat elektroda (Al-Fe), (Fe-Al-Fe), (Al-Fe-Al-Fe) berturut-turut adalah 82,5; 87,5; dan 90,0%. Semakin banyak jumlah pelat pada elektrokoagulasi mikroplastik dapat meningkatkan efektifitas pengurangan mikroplastik. Gugus fungsi yang terkandung dalam masker sebelum dan sesudah elektrokoagulasi mempunyai kemiripan dengan flok yang dihasilkan. Gumpalan Flok hasil elektrokoagulasi berbentuk variatif dan terdapat serat.
UMLS-Based Approach for Developing VoiS: Voice-Activated Conversational Agent for Self-Management of Multiple Chronic Conditions
Authors: Park Min Sook , Oh Hyunkyoung , Luo Jake , Ahamed Sheikh Iqbal , Upama Paramita Basak , Anik Adib Ahmed , Tian Shiyu , Rabbani Masud
Published: January 2024

This abstract proposes a system design for an ontology-based conversational agent (CA) for the self-management of chronic conditions. The proposed system plans to integrate the largest medical ontology, the Unified Medical Language System (UMLS) (Bodenreider, 2004), aiming to narrow the vocabulary gaps between health professionals and patients and to make the agent more responsive to the users.

Recently, conversational agents (CAs) like ChatGPT, or computer dialog systems that simulate human-to-human communication in natural language, have risen and gained popularity in various health contexts (Bin Sawad et al., 2022; Montenegro et al., 2019) including self-management of chronic conditions (Griffin et al., 2020). Despite their potential, the currently available CAs are often criticized for lacking the capability to understand natural language inputs (Montenegro et al., 2019). This limitation can be highlighted in medical areas due to the known vocabulary gaps between health professionals and health consumers. The knowledge-grounded dialog flow for CAs presents the potential to lift this limitation, making CAs naturally converse with their users.

In the proposed voice-activated self-monitoring support (VoiS) application, the research team plans to integrate the UMLS to make the agent better understand lay terms from patients and properly map those terms to medical concepts. This automated process is expected to improve the user experience in two folds: a) promote the quality of communication between the patients and health providers and b) make the VoiS app more responsive to user inputs, overcoming accepting only constrained user inputs (e.g., multiple choice of utterance).
Culturally Adapting the World Health Organization Digital Intervention for Family Caregivers of People With Dementia (iSupport): Community-Based Participatory Approach
Authors: Messina Anna , Amati Rebecca , Annoni Anna Maria , Bano Beatrice , Albanese Emiliano , Fiordelli Maddalena
Published: January 2024

Background

Informal caregivers of people with dementia are at high risk of developing mental and physical distress because of the intensity of the care provided. iSupport is an evidence-based digital program developed by the World Health Organization to provide education and support for the informal everyday care of people living with dementia.

Objective

Our study aims to describe in detail the cultural adaptation process of iSupport in Switzerland. We specifically focused on the participatory strategies we used to design a culturally adapted, Swiss version of iSupport that informed the development of the desktop version, mobile app, and printed manual.

Methods

We used a mixed methods design, with a community-based participatory approach. The adaptation of iSupport followed the World Health Organization adaptation guidelines and was developed in 4 phases: content translation, linguistic and cultural revision by the members of the community advisory board, validation with formal and informal caregivers, and refinement and final adaptation.

Results

The findings from each phase showed and consolidated the adjustments needed for a culturally adapted, Swiss version of iSupport. We collected feedback and implemented changes related to the following areas: language register and expressions (eg, from “lesson” to “chapter” and from “suffering from” dementia to “affected by” dementia), resources (hyperlinks to local resources for dementia), contents (eg, from general nonfamiliar scenarios to local and verisimilar examples), graphics (eg, from generalized illustrations of objects to human illustrations), and extra features (eg, a glossary, a forum session, and a read-aloud option, as well as a navigation survey).

Conclusions

Our study provides evidence on how to culturally adapt a digital program for informal caregivers of people living with dementia. Our results suggest that adopting a community-based participatory approach and collecting lived experiences from the final users and stakeholders is crucial to meet local needs and to inform the further development, testing, and implementation of digital interventions in a specific cultural context.
Health Care Professional–Supported Co-Design of a Mime Therapy–Based Serious Game for Facial Rehabilitation (Preprint)
Authors: Sousa Daniel Lima , Teixeira Silmar , Fontenele José Everton , Santos Renato Mendes , Pereira Leynilson , Baluz Rodrigo , Bastos Victor Hugo , Teles Ariel Soares
Published: January 2024

UNSTRUCTURED

This research letter presents the co-design process for RG4Face, a mime therapy–based serious game that uses computer vision for human facial movement recognition and estimation to help health care professionals and patients in the facial rehabilitation process.
Finding Predictors of Success for Remote Monitoring in Psoriasis: Insights from A Cross-Care Level Multi-Site Study and Country-Wide Insurance Database (Preprint)
Authors: Lember Maarja , Kruus Priit , Kingo Külli , Ross Peeter , Kapanoglu Secil
Published: January 2024

BACKGROUND

Psoriasis is a lifelong, relapsing, quick-to-flare skin disease that requires personalised, continuous management. Due to its unpredictable nature, there is an increased interest in employing electronic patient-reported outcome measures (ePROMs) for remote monitoring of the condition. However, adherence and predictors of adherence have not been sufficiently explored among patients with psoriasis.

OBJECTIVE

This study aims to assess the adherence to ePROMs and the predictors of adherence among patients with psoriasis.

METHODS

In this study, we utilised a quasi-experimental multi-site trial to measure adherence to ePROMs of 55 patients managed in primary care and 55 in specialised care for six months. We co-analysed it alongside the longitudinal healthcare data recorded in the country-wide health insurance database – a unique dataset previously unavailable for researchers of remote monitoring.
While continuing with routine clinical care, patients were periodically prompted to fill ePROMs. Adherence for both care levels was calculated, and predictors were assessed using Chi-square.

RESULTS

The adherence ratio was 60% ± 32.2% (N=110) and was similar in primary and specialised care groups. A significant, inverse association between diabetes and adherence (Fisher’s exact test, p=.022) was found from 29 investigated factors.

CONCLUSIONS

This study adds to existing research on using ePROMs in chronic diseases while demonstrating the feasibility of utilising ePROMs for remote monitoring of chronic skin diseases and at cross-care levels. Findings provide valuable insights into predictors of adherence, which are crucial for developing personalised approaches to improve the effectiveness of remote monitoring with ePROMs in psoriasis.

CLINICALTRIAL

Research Ethics Committee of the University of Tartu, Estonia (ethical approval code: 350/T-14).
Parametric Study of the Effect of Diameter-to-Thickness Ratio Against Bending and Shear Load on the Behavior of Round Hollow Structural Section Beam
Authors: Kori Effendi Mahmud , Yulianto Hariadi
Published: January 2024

The steel-constructed buildings in Indonesia are on the rise, indicating a growing preference for their durability and versatility in construction projects. This led to the general application of Round Hollow Structural Section (Round HSS) as column and beam elements. Therefore, this study aimed to conduct parametric analysis of the effect of Diameter-to-Thickness Ratio (D t-1) on the three-point and four-point flexural analysis of Round HSS beam using MSC Marc/Mentat software. Nonlinear materials and geometries were employed, along with the application of contact analysis, with contacted and contacting bodies. Moreover, the load and boundary condition were set to be similar to the experiment. The results showed that a greater D t-1 led to the possibility of withholding a smaller load and causing smaller displacement in Group A with fixed diameter and different thickness values. Meanwhile, in Group B with fixed thickness but different diameters, a greater D t-1 led to the potential of restraining more load and experiencing smaller displacement. All specimens from both groups were observed to have failed due to a combination of global and local buckling at the right location under the load applied. AISC bending moment calculated was found to be greater than the values obtained from the finite element analysis for all sections under three-point loads. It was also discovered in the four-point flexural analysis that the bending moment of noncompact section was greater than for AISC while those for the compact section were lower. Furthermore, shear strength (Vn) calculated was observed to be greater thanshear force from finite element analysis (Pmax/2).
Reverse Phenotypes of Patients with Genetically Confirmed Liddle Syndrome
Authors: Granhøj Jeff , Nøhr Thomas K. , Hinrichs Gitte R. , Rasmussen Maria , Svenningsen Per
Published: January 2024

Background

Liddle syndrome was initially characterized by hypertension, hypokalemia, metabolic alkalosis, and suppressed plasma renin and aldosterone, resulting from gain-of-function variants in the epithelial Na+ channel (ENaC). Efficient treatment with ENaC inhibitors is available, but the phenotypic spectrum of genetically confirmed Liddle syndrome is unknown, and some patients may remain undiagnosed and at risk of inefficient treatment. In this study, we used a reverse phenotyping approach to investigate the Liddle syndrome phenotypic spectrum and genotype–phenotype correlations.

Methods

Pubmed, Embase, Scopus, and the Human Gene Mutation Database were searched for articles reporting Liddle syndrome variants. The genetic variants were systematically classified to identify patients with genetically confirmed Liddle syndrome. We identified 62 articles describing 45 unique variants within 86 Liddle syndrome families, and phenotypic data were pooled for 268 patients with confirmed Liddle syndrome.

Results

The Liddle syndrome variants localized to exon 13 of SCNN1B and SCNN1G, disrupting the PPPxY motif critical for downregulating ENaC activity. Hypertension sensitive to ENaC inhibition was present in 97% of adults carrying Liddle syndrome variants while hypokalemia, metabolic alkalosis, and plasma renin and aldosterone suppression showed incomplete penetrance. In addition, 95% and 55% of patients had a family history of hypertension or cerebrovascular events, respectively. The genotype had minor phenotypic effects; however, probands compared with relatives showed significant phenotypic discrepancies consistent with selection bias for initial genetic screening.

Conclusions

Patients with genetically confirmed Liddle syndrome displayed a phenotypic spectrum, with ENaC-sensitive hypertension and family history of hypertension being the most common features. The phenotype seemed independent of the specific gene or variant type involved.
Homenaje al profesor Prudencio Moscoso Pastrana (1913-1991)
Authors: Fábregas Puig Andrés , González Casanova H. Pablo , Morales Avendaño Juan María , Gordillo y Ortiz Octavio , Robledo Santiago Edgar , Pineda del Valle César , Morales Constantino Martha Azucena , Marín Rizo Gilberto , Fernández Galán Rodríguez Maria Elena , Paniagua Herrera Jorge , Pineda Luz Olivia , Villanueva Irasema , Esponda Jimeno Víctor Manuel , Köhler Ulrich , Laughlin Robert M. , Pérez Castro Ana Bella , Lee Whiting Thomas A. , Markman Sidney David
Published: January 2024

Prudencio Moscoso PPrudencio Moscoso Pastrana, distinguido sancristobalense, quien durante su vida ejerció la cátedra con gran amor y devoción, se preocupó por conocer y divulgar las leyendas, tradiciones y la historia, no solamente de su ciudad natal, la colonial San Cristóbal de Las Casas, sino también de Chiapas, a quien dedicó parte de su producción escrita. Infatigable siempre por el pasado, erudito en sus doctas conferencias y singular conversador fueron atributos que lo caracterizaron. Su interés por los libros y documentos lo llevó a reunir un importante acervo chiapaneco, mismo que representa para esta región de nuestro país un fundamental caudal de información para todos aquellos estudiosos por conocer la cultura de Chiapas. El presente homenaje a su memoria es un testimonio en reconocimiento a su labor como maestro, investigador e historiador.astrana, distinguido sancristobalense, quien durante su vida ejerció la cátedra con gran amor y devoción, se preocupó por conocer y divulgar las leyendas, tradiciones y la historia, no solamente de su ciudad natal, la colonial San Cristóbal de Las Casas, sino también de Chiapas, a quien dedicó parte de su producción escrita. Infatigable siempre por el pasado, erudito en sus doctas conferencias y singular conversador fueron atributos que lo caracterizaron. Su interés por los libros y documentos lo llevó a reunir un importante acervo chiapaneco, mismo que representa para esta región de nuestro país un fundamental caudal de información para todos aquellos estudiosos por conocer la cultura de Chiapas. El presente homenaje a su memoria es un testimonio en reconocimiento a su labor como maestro, investigador e historiador.
Modernización y desarrollo regional en Chiapas, un caso: la zona libre de Tapachula
Authors: Ordoñez Morales César Eduardo
Published: January 2024

La zona libre de la franja fronteriza sur, colindante con Guatemala, fue decretada el 22 de agosto de 1989, con intenciones de promover el crecimiento industrial y comercial, así como nuevas modalidades de vinculación de la economía chiapaneca con la economía internacional. No había una tendencia endógena de industrialización suficientemente fuerte y al implementarse en pleno proceso de apertura de la economía nacional fue una respuesta tardía a demandas añejas del capital comercial del Soconusco. Se han realizado acciones de inversión pública federal y estatal, pero no han llegado flujos importantes de inversión nacional y transnacional. Experimenta obstáculos técnicos y sociales derivados de las dificultades para superar el modelo agroexportador, para crear o aprovechar ventajas de localización respecto a importantes mercados nacionales y mundiales, así como para desarrollar relaciones económicas con Centroamérica. Este proyecto, poco exitoso, de desarrollo regional en el marco del actual modelo económico mexicano, ofrece lecciones que es necesario aprender, en la búsqueda de propuestas para el desarrollo económico de Chiapas.
José María Luis Mora. Dialéctica: razón-ley-libertad
Authors: Guerrero Sotelo Roxana Nayeli
Published: January 2024

El objetivo de esta reflexión es analizar el pensamiento desarrollado por José María Luis Mora Lamadrid a fin de proponer una interpretación sustentada en la dialéctica entre razón-ley-libertad. Para lo anterior se realiza un breve análisis de la vida y obra del autor, seguido de la identificación y análisis de las influencias recibidas entre las que destacan la Ilustración, el liberalismo, la escolástica, la Contrailustración y el ideario de la masonería escocesa, seguido del estudio del contexto político mexicano.
Complex field survey of the Tyatinskiy part of the “Kurilskiy” state nature reserve, Kunashir island, Kuril islands
Authors: Grishchenko Mikhail Yu. , Murman Anna S. , Tamarovskiy Igor E. , Terekhova Darya A. , Satosina Elizaveta M. , Shelukho Veronika V. , Avchyan Anton S. , Ushakov Nikolay V.
Published: January 2024

The study describes the results of field expeditionary research conducted by the authors on the territory of the Tyatinskiy cluster of the “Kurilskiy” state nature reserve (Kunashir island, the Great Kuril Ridge). The nature of the island is distinguished by its bright originality and is interesting for research both from the point of view of increasing the tourist, recreational and education attractiveness, and from the point of view of the implementation of environmental activities. During the research, a study of soils, vegetation cover and some climatic characteristics of the territory was carried out. It was revealed that the soils of the study area are mainly soils that combine the features of brown soils and volcanic soils; local plant communities are represented mainly by dark coniferous forests with a rich and varied admixture of broad-leaved species in the forest stand, the absence of pronounced undergrowth, a diverse grass-shrub canopy and a well-developed moss-lichen layer.
Assessment of the impact of vehicle emissions on the geoecological state of soils and vegetation in the cities of the Irkutsk agglomeration
Authors: Novikova Svetlana A.
Published: January 2024

The study examines the problem of the influence of vehicle emissions on the condition of soils and vegetation of roadside strips in the cities of the Irkutsk agglomeration. Sampling was carried out near intersections characterized by intense traffic flows. As a result of a mass (semi-quantitative) full spectral analysis of selected samples, the content of heavy metals in them was revealed to be higher than the maximum permissible and background concentrations. Calculations of the total pollution indicator were carried out, which made it possible to establish that the soils of roadside zones in urbanized areas of the agglomeration belong to the categories “dangerous” and “extremely dangerous”. Recommendations for improving the geoecological condition of soils and vegetation in urban areas are given.
Influence of phytoplankton on the water quality of surface water sources and drinking water
Authors: Kalinina Elena V. , Rudakova Larisa V.
Published: January 2024

The problem of the appearance of odors in drinking water associated with the development of algae and cyanobacteria in reservoirs of drinking water sources is considered. The results of the analysis of information on the main types of organisms that are sources of odorants in drinking water, chemicals produced by them and a description of odors are presented. Most often, the causes of odors in drinking water are the massive development of Aphanizomenon flos-aquae and Oscillatoria agardhii , which are producers of geosmin and 2-methylisoborneol. The classification of hazard levels for water pollution by cyanobacteria and recommended measures, including the frequency of monitoring and sampling, are given. The measures implemented with a decrease in the number of cyanobacteria in reservoirs of drinking water supply sources by physical, chemical and biological methods are presented. Methods of removal of intracellular and extracellular cyanotoxins from drinking water are described. The analysis of the efficiency of removal of various substances with odorizing effect from drinking water is presented.
EFFECT OF SiO2 AND ZnO NANOPARTICLES TO INCREASE REFRIGERATION MACHINE PERFORMANCE
Authors: Irwansyah Dandi , Sundari Rita , Anggraini Rini , Arifin Khuzaimah
Published: January 2024

In this investigation, the impact of silicon dioxide (SiO2) and zinc oxide (ZnO) nanoparticles on the performance of a refrigeration machine system was systematically examined. The focus was on evaluating the coefficient of performance (COP) concerning the utilization of a polyolester (POE) lubricant, R600a refrigerant, and distinct nanoparticles (SiO2 and ZnO) within the refrigeration system. The nanoparticles were individually introduced into the R600a refrigerant in masses of 0.5 g, 1.0 g, and 1.5 g. The experimental outcomes demonstrated a noteworthy enhancement in COP with the addition of nanoparticles. Specifically, the introduction of 1.5 g of SiO2 resulted in a substantial increase of 25.88% in COP, marking it as the most influential dosage. Similarly, the addition of 1.0 g of ZnO led to a significant COP increase of 13.6%, representing the optimal quantity for ZnO. Furthermore, the inclusion of 1.5 g of SiO2 brought about a remarkable reduction in energy consumption, with a decrease of 25.58%, while 1.5 g of ZnO resulted in a notable 16.28% decrease in energy consumption. The experimental configuration involved the use of 20 g of refrigerant and 500 ml of POE lubricant. Comparative analysis demonstrated that the refrigeration system incorporating nanoparticles outperformed the conventional R600a refrigeration system devoid of nanoparticles. This study contributes valuable insights into the potential enhancements in refrigeration system efficiency through the strategic incorporation of SiO2 and ZnO nanoparticles, offering a promising avenue for optimizing the performance of refrigeration technology.
ENHANCING HIGH-SPEED PERFORMANCE: MODIFICATION OF BOOM BARRIER GATE WITH PUSH BRAKING SYSTEM FOR ETC APPLICATION
Authors: Nafis Muhammad Luthfi , Pranoto Hadi , Youlia Rikko Putra
Published: January 2024

Congestion at toll roads has become a pervasive issue in contemporary times, predominantly manifesting at toll booths during the payment process. A noteworthy contributor to this congestion has been identified as the sluggish operational speed of boom gates. In response to this challenge, a modification strategy was implemented to enhance the operational efficiency of existing boom gates. The primary modification involved substituting the conventional electric motor with a more advanced Brushless DC (BLDC) motor boasting a power rating of 660 watts. Additionally, an innovative augmentation integrated a motorcycle disk brake system into the boom gate mechanism. Replacing the original electric motor's internal brake system with the disk brake system aimed to optimize the overall performance of the boom gate. The integration of the motorcycle disk brake system was further complemented by incorporating the push braking system (knoken braking system), serving as the actuator instead of the traditional motorcycle lever handle. This strategic substitution was instrumental in activating the disk brake function at the boom gate. During peak rush hours, the modified boom gate underwent rigorous testing at both the Ciawi and Kelapa Gading toll gates. Results from the trial activities unveiled a remarkable improvement in the boom gate's operational speed. Specifically, the opening speed demonstrated an impressive surge of 51 percent, catapulting from 548 ms to 265 ms. Similarly, the closing speed exhibited a commendable enhancement of 44 percent, elevating from 602 ms to 332 ms. Furthermore, the boom gate cycle per hour experienced a notable escalation, increasing by 25 percent from 356 to 449 cars per hour. These findings underscore the efficacy of the implemented modifications in ameliorating congestion issues at toll booths.
Improvisation Three: Another Shifting Landscape
Authors: Tor Einar Bekken
Published: January 2024

A short film by Tor Einar Bekken from the Ila/Skansen harbour, Trondheim, Norway.
Music improvised by Tor Einar Bekken, acoustic guitar.
Ionosphere characterization using GPS P3 method by measuring ionospheric delay in Southeast of Brazil and considering geomagnetic storms.
Authors: Yamada Fábio Kei , Tarelho Luiz Vicente , Lima Mauro Vieira de
Published: January 2024

Ionospheric refraction introduces significant delay and fading in the
electromagnetic signals. This makes the ionosphere the most harmful
layer of the Earth’s atmosphere to the electromagnetic signals emitted
by satellites, impacting the reliability of GNSS services. Depending on
the ionization level of the ionosphere plasma and the signal frequency,
these errors can vary from a few meters to signal unavailability. The
main factors influencing ionosphere plasma’s ionization level are the
intensity of solar radiation and the Earth’s magnetic field. The main
parameter to evaluate the behavior of the ionosphere is the Total
Electron Content (TEC), existing between the satellite and the
terrestrial receiver antenna. By predicting the TEC value, it is
possible to predict the effects of ionospheric refraction and develop
techniques to increase reliability in services that depend on GNSS. This
study spans the four seasons from 2018 to 2023, utilizing measurements
of ionospheric delays collected by the UTC(INXE). Daily, seasonal, and
annual variations in Vertical TEC (VTEC) values are analyzed. A
comparative assessment is made between the VTEC values obtained by the
GPS P3 method and the Ionospheric Map method for each season until
winter 2023. The Analysis of Variance demonstrated the compatibility and
comparability of the two methods. Additionally, this investigation
explores changes in the ionosphere behavior at the UTC(INXE) location
during the geomagnetic storms caused by the solar explosions on April
21, 2023. The findings provide valuable insights for the ionosphere
dynamics and can contribute to developing techniques to improve GNSS
services’ reliability.
Evaluation of Mesoscale Convective Systems in High Resolution E3SMv2
Authors: Zhang Meng , Xie Shaocheng , Feng Zhe , Terai Christopher Ryutaro , Lin Wuyin , Chen Chih-Chieh , Fan Jiwen , Golaz Jean-Christophe , Leung L. Ruby , Richter Jadwiga H. , Shan Yunpeng , Song Xiaoliang , Tang Qi , Zhang Guang J.
Published: January 2024

Mesoscale convective systems (MCSs) play an important role in modulating
the global hydrological cycle, general circulation, and radiative energy
budget. In this study, we evaluate MCS simulations in the second version
of U.S. Department of Energy (DOE) Energy Exascale Earth System Model
(E3SMv2). E3SMv2 atmosphere model (EAMv2) is run at the uniform 0.25°
horizontal resolution. We track MCSs consistently in the model and
observations using the PyFLEXTRKR algorithm, which defines MCS based on
both cloud-top brightness temperature (Tb) and surface precipitation.
Results from using Tb only to define MCS, commonly used in previous
studies, are also discussed. Furthermore, sensitivity experiments are
performed to examine the impact of new cloud and convection
parameterizations developed for EAMv3 on simulated MCSs.

Our results show that EAMv2 simulated MCS precipitation is largely
underestimated in the tropics and contiguous United States. This is
mainly attributed to the underestimated precipitation intensity in
EAMv2. In contrast, the simulated MCS frequency becomes more comparable
to observations if MCSs are defined only based on cloud-top Tb. The
Tb-based MCS tracking method, however, includes many cloud systems with
very weak precipitation which conflicts with the MCS definition. This
result illustrates the importance of accounting for precipitation in
evaluating simulated MCSs. We also find that the new physics
parameterizations help increase the relative contribution of convective
precipitation to total precipitation in the tropics, but the simulated
MCS properties are overall not significantly improved. This suggests
that simulating MCSs will remain a challenge for the next version of
E3SM.
Cultural heritage as an initiator of urban development: The city square in Brcko
Authors: Bulatovic Slobodan
Published: January 2024

Locations, where cultural heritage is located are potential drivers of urban
development due to their importance in the urban space and social community.
These buildings worldwide influence cities' economic, sociological and urban
development. Such a case can be seen in the town square in Brcko. This
square is the subject of analysis to examine cultural heritage's influence
on urban development. The paper examines the importance of cultural heritage
buildings in urban development by analyzing planning documents based on
which cultural heritage mapping was done. After that, the quality of the
town square in the Brcko area was determined with the help of specific
quality criteria. The results indicated the role of cultural heritage
buildings in driving urban development. Based on the results, guidelines and
recommendations were given for adequate inclusion of cultural heritage in
urban development.
To Study the Impact of Science Teaching Methodologies on Students Achievement: A Case Study of Students of District Khairpur Mirs
Authors: Karim Suhag Abdul
Published: January 2024

Students’ attention towards learning science subjects appears to be reducing at all levels of education in developing countries like Pakistan. This problem is influenced by science teaching methodology and learning processes. The exploration of factors influencing teaching and learning provided suitable information for enhancing the learning of science subjects. Main objective of this study is to discover science teaching and learning methodology in secondary schools of District Khairpur Mir’s. The Questionnaire was prepared for students to explore the aspects that motivate students towards study. The questionnaire identifies teaching methodologies with students’ achievements in response of their results. A sample of 82 students (both male and female) was selected from different schools of District Khairpur Mir’s. The age of the participants ranged between 15-18 years (with mean of 15.56 years). Their educational levels were at least ninth and tenth class and socio-economic status were lower-middle and upper-middle income groups. The data obtained were tabulated and analyzed by percentage values.
Variations Related to Resistance of Cancer Cells to Topoisomerase II Alpha Inhibitory Drugs
Authors: Vallian Sadeq
Published: January 2024

DNA topoisomerase II alpha (Top2-α) enzyme is an important target for many anticancer drugs. A variety of TOP2A genomic variants has been found associated with the development of drug resistance to this enzyme, resulting in chemotherapy resistance. Chemotherapy resistance is the ability of cancer cells to survive and grow despite anti-cancer therapies. Increasing information show that genomic variations such as mutations and polymorphisms play an important role in chemotherapy resistance. Here, the available information on mutations that affect the response of Top2-α to its inhibitory drugs was reviewed.
Temperature Data in 3d Structure Reveal the Internal Cod Involvement in Molecular Form
Authors: Rajasekaran Ekambaram
Published: January 2024

Addition of small molecule into force is going to be the task of another rule based activation for any meaningful application in biology of Animalia kingdom of existence. Otherwise it is mandatory to fulfill the norms for adequacy principle arising out of carbon value in force here in protein or other where carbon alone dominates the due course of action and all. Accordingly we have developed an internal one proposal for any meaningful application in carbon based study of intervening elements of interaction arising from carbon value. Additional to existing calculations in modeling, it is going to be the one and only force will dominate the scenario of molecular alteration for many salvations in living organisms. According to rule of law coming from carbon profile, the hydrogen atom also to be the main part of the value calculation and all. According to new force of carbon calculation, it is here calculated to be the internal one of carbon profile found in 3D structure where another part of intervening elements taken into account. As part of this work the internal carbon values are compared to temperature factor value of crystal valuation. Accordingly the tested molecule of super oxide dismutase obeys this internal one and all other parameters needed to incorporate therein. Interestingly the internal values dominate the scenario of uncertainty arising here in temperature factor for protein as well as in RNA or DNA. Very well documented internal values are crucial for any meaningful application where other modifications arising for alteration at the vicinity of active role played by proteins and so on. One can trust these developments for any meaningful applications arising for disease solving or control and also for proteome of future applications. Over and above this evolving newly developed one going to be the task of newly existence of successful run for the future one.
Effects of Turmeric Oil as a Dietary Supplements on the Hematology and Serum Biochemical Indices of Broiler Chickens
Authors: JO Alagbe
Published: January 2024

The objective of this current study was to examine the effects of turmeric oil as a dietary supplement on some haematological and serum biochemical indices of broiler chicken. A total of two hundred 1-day-old broiler chicks (Ross 308 strain) were randomly distributed to five treatments of 4 replicates consisting of 10 birds each in a completely randomized design. Birds in treatment 1 (T1) were fed basal diet + 0% turmeric oil (TOL), T2, T3, T4 and T5 were fed basal diet supplemented with TOL at 0.1%, 0.2%, 0.3% and 0.4% respectively. Basal diet was formulated to meet the nutritional requirements of birds according to NRC (1994). Clean feed and water were also provided ad libitum throughout the experiment which lasted for 56 days. Results obtained showed that all the haematological parameters (Pack cell volume, haemoglobin, red blood cell, mean corpuscular volume, mean corpuscular heamoglobin, mean corpuscular haemoglobin concentration, white blood cells and its differentials) were significantly (P˂0.05) different among the treatments. Serum biochemical parameters (Total protein, albumin, globulin, cholesterol, alanine transaminase, aspartate transaminase) were influenced by the dietary supplementation of TOL (P˂0.05). Cholesterol level decreases as the dietary supplementation of TOL increases (P˂0.05). However, all values were within the normal physiological range for birds. It was concluded that TOL contains several bioactive chemicals which confers it the ability to perform multiple biological functions.
Bioinformatics and Artificial Intelligence to Combat Covid-19 and Beyond
Authors: Sharma Dhirendra
Published: January 2024

COVID-19 perhaps is the greatest and tremendously significant crisis against Homo sapiens sapiens in the contemporary history of the globe. The group of coronaviridae includes viruses with very long RNA genomes up to 33000 nucleotides. SARS-CoV-2 belongs to the Sarbecovirus provided with approximate genome size of 30000 nucleotides.