bluuebunny/crossref_metadata_2025 huggingface dataset:
Profile of people living with cancer followed in the palliative care unit of Parakou, Benin in 2021
Authors: Adébayo ALASSANI  , Albert Comlan DOVONOU  , Khadidjatou SAKE  , Armand WANVOEGBE  , Anthelme AGBODANDE
Published: April 2023

Introduction: Cancer is a global public health problem. This study focused on the the profile of people living with cancer in Parakou. Study method: This was a cross-sectional, descriptive and analytical study which enrolled people living with cancer followed in the palliative heath care of the internal medicine unit at the Regional University Health Center of Borgou who had given their consent. The variables of the study were: sociodemographic data, nutritional status, comorbidities, circumstances of cancer screening and their location. Data analysis was performed using Epi Data 3.1 software. Results: The study population consisted of 264 people with cancer. A male predominance was observed with a sex ratio of 2.66. The average age was 47.51 years ±13.20. Alcohol consumption was observed in 15.2%. Arterial hypertension was found in 63.6% of subjects. On the nutritional level, malnutrition and weight loss were observed respectively in 68.2% and 98.1% of patients. Abdominal pain, asthenia and weight loss were the main circumstances for cancer screening and were present in 37.1%, 27.6% and 16.7% of participants respectively. Liver cancer was found in the majority (72%) of the participants. Viral hepatitis B was the most common cause with 98.3% Conclusion: cancer affects young adults and is often detected at an advanced stage. The main site is the liver and infection with the hepatitis B virus is found in most of the cases.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS) TERHADAP HASIL BELAJAR KOGNITIF IPA
Authors: Ismalia Ismalia , Sukarno Sukarno , Jerfi Jerfi
Published: April 2023

Penelitian ini dilatarbelakangi oleh rendahnya hasil belajar IPA siswa. Oleh karena itu, dilakukan penelitian untuk mengetahui pengaruh model pembelajaran kooperatif Think Pair Share (TPS) terhadap hasil belajar IPA siswa kelas VII MTs Nurul Khairiyah. Jenis penelitian ini adalah quasi eksperimen dengan menggunakan desain pre-post control group design. Sampel penelitian terdiri dari siswa kelas VII A dan VII B. Uji instrumen dilakukan di sekolah yang sama yaitu di kelas VIII A sebanyak 31 siswa. Instrument pengumpulan data dalam penelitian ini menggunakan tes hasil belajar berupa 30 soal pilihan ganda. Data yang diperoleh dianalisis dengan menggunakan uji normalitas, uji homogenitas, dan uji hipotesis (uji-t independen). Hasil perhitungan uji-t dengan hasil penelitian dan taraf signifikansi 5% diperoleh T- tabel sebesar 2,021 dan Thitung sebesar 3,688. Berdasarkan kriteria/syarat pengujian hipotesis, diperoleh Thitung > Ttabel 3,688 > 2,021. Oleh karena itu, dapat disimpulkan bahwa Ha diterima dan H0 ditolak. Hal ini menunjukkan terdapat pengaruh signifikan penerapan model pembelajaran kooperatif Think Pair Share (TPS) terhadap hasil belajar kognitif pembahasan kalor dan perpindahan pada siswa MTs Nurul Khairiyah.
Machine-Learning-Based Deconvolution Method Provides High-Resolution Fast Inversion of Induction Log Data
Authors:   Formerly Aramco Americas, Hagiwara Teruhiko ,   Terry R&D
Published: April 2023

We built a deconvolution model for induction log data using machine learning (ML). Unlike iterative forward modeling inversion methods, the deconvolution model is extremely fast. Unlike linear deconvolution models in the past, ML-based deconvolution finds accurate layer resistivity and layer boundaries. For a unit induction tool 2C40, the 21-point, 10-ft window deconvolution model works satisfactorily.
An Unsupervised Machine-Learning Workflow for Outlier Detection and Log Editing With Prediction Uncertainty
Authors:   SLB, Akkurt Ridvan , Conroy Tim T. ,   Woodside, Psaila David ,   AnalyticSignal, Paxton Andrea ,   SLB, Low Jacob ,   Woodside, Spaans Paul ,   Woodside
Published: April 2023

Recent advances in data science and machine learning (ML) have brought the benefits of these technologies closer to the mainstream of petrophysics. ML systems, where decisions and self-checks are made by carefully designed algorithms, in addition to executing typical tasks such as classification and regression, offer efficient and liberating solutions to the modern petrophysicist. The outline of such a system and its application in the form of a multilevel workflow to a 59-well multifield study are presented in this paper. The main objective of the workflow is to identify outliers in bulk density and compressional slowness logs and to reconstruct them using data-driven predictive models. A secondary objective of the project is to predict shear slowness in zones where such data do not exist. The system is fully automated, designed to optimize the use of all available data, and provide uncertainty estimates. It integrates modern concepts for outlier detection, predictive classification, and regression, as well as multidimensional scaling based on inter-well similarity. Benchmarking of ML results against those created by experienced petrophysicists shows that the ML workflow can provide high-quality answers that compare favorably to those produced by human experts. A second validation exercise, that compares acoustic impedance logs computed from ML answers to actual seismic data, provides further evidence for the accuracy of the ML-generated results. The ML system supports the petrophysicist by easing the burden on repetitive and burdensome quality control tasks. The efficiency gains and time savings created can be used for enhanced effective cross-discipline integration, collaboration, and further innovation.
Lip Reconstruction Using Radial Forearm Freeflap After Radical Excision of Squamous Cell Carcinoma: A Case Report
Authors: Setiawan Eko , Sari Erythrina Permata
Published: April 2023

INTRODUCTION: The main treatment modality for squamous cell carcinoma of the head and neck is by surgical wide excision. Post-excision reconstructive surgery is essential for restoring aesthetics and function. Fasciocutaneous free-flap is an acceptable method for reconstructing a wide lession of the face since the technique does not cause significant morbidity.CASE REPORT: A 41 year-old female was diagnosed with squamous cell carcinoma (T3N0M0) of the inferior lip after achieving tumor-free margin radical excision. Reconstruction of the defect was made with radial forearm freelap followed by a three-phase refinement flap. The patient was left with a aesthetically acceptable lip without other facial morbidity.DISCUSSION: Reconstructive surgery following a widely excised tumor of the lips requires special attention because of its important physical and aesthetical role. Radial forearm freeflap causes minimal facial morbidity since the technique does not require donor tissue from the face. Other benefits include adequate tissue thickness, minimal contracture and unaltering skin color. Further refinement flaps is needed to complete the reconstruction process.CONCLUSION: Radial forearm free flap is a good choice for reconstruction a wide lession following a wide excision of lip tumor.
The Effect of Administering Lemon Basil (Ocimum sanctum) Leaves on FSH and LH Estrogen Levels and Size of Ovarian Antral Follicle in Female Balb/C Mice
Authors: Maryanti Sri , Nasihun Taufiqurrachman , Amalia Helfi
Published: April 2023

INTRODUCTION: Ocimum sanctum have been proven effective in decreasing Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) levels, and sperm number, and also increase male testosterone levels. However, so far no evidence has been found on the effect of Ocimum sanctum leaves on the levels of estrogen, FSH, LH, and the size of ovarian anthral follicles. OBJECTIVES: To evaluate the effect of Ocimum sanctum leaves on estrogen, FSH, LH and the size of antral follicle of female Balb/C mice.METHODS: In the post test only control group design, 12 female Balb/C mice were assigned into 2 groups. The treatment group (OS-G) was given 0.08 gram of ocimum sanctum leaves, three times a day for 30 days and the control group (C-G) received no ocimum sanctum. Estrogen, FSH anduLH levels wereumeasured on the 30th day, the mice were sacrificed and taken up by their ovaries. HE preparationsuwere then madeuand HE was performed, and the size of the antral follicle of the ovary was measured .RESULTS: Mann Whitney analysisuindicateduthat estrogen and FSH levels in OS-G group were significantly higher compared to that of C-G group, p<0.05. Based on independent t-test, the level of LH in OS-G was significantly higher than that of C-Gugroup, p><0.05. On the contrary, uthe size of ovarianuanthralufollicle in OS-Guwas smaller than that of C-Gugroup, p><0.05. CONCLUSION: Ocimum sanctum increased the levels of estrogen, FSH, LH and decreased the size of ovarian antral follicle in female of Balb/C mice.>
The Effect of Administration of Longan (DimocarpusLonganL Steud)Leaf Extract Cream on Collagen Density and MMP-1 Expression in the Dermis of BALB/C Mice Exposed to UV-B Rays
Authors: Maryam Mulyaningsih Ruri Eka , Hussaana Atina , Chodidjah Chodidjah
Published: April 2023

INTRODUCTION: UV-B exposure to the skin may produce ROS, decreasing collagen density and increasing MMP-1 expression. Longan leaf extract cream contains antioxidant and is expected to prevent decrease in collagen density and MMP-1 expression increase.OBJECTIVE: The research aims at administering longan leaf extract cream to increase collagen density and decrease MMP-1 expression in BALB/c mice exposed to UV-B rays.METHODS: This experimental research employed a Post Test Only Controlled Group Design. The subjects were 24 BALB/c mice, which were randomly divided into 4 groups. The Control Group (Ctr-G)was only administered with basic cream and exposed to UV-B rays, while Groups DLS-3, DLS-6, and DLS-13were respectively administered with longan leaf extract cream at doses 3.25%, 6.5% and 13% and exposed to UV-B rays for 4 weeks at a dose of 1 MED. On day 29, a tissue excision biopsy was performed to determine the collagen density and MMP-1 expression. The collagen density preparations were made using Masson’s Trichome staining and MMP-1 preparations were made using immunohistochemical staining.RESULTS: Kruskalwallis analysis showedstatistically no significant differences in collagen density and MMP-1 expression between groups(p value> 0.05).CONCLUSION: Administration of longan leaf extract cream at doses of 3.25%, 6.5% and 13% had proven unable to increase collagen densitynor decrease the MMP-1 expression significantly after UVB exposure.
The Influence of Administering Propolis CMCE Extract on FSH, LH, and Testosterone Levels in MSG-Induced Male Wistar Rat
Authors: Sofyanita Eko Naning , Nasihun Taufiqurrachman , Zulaikhah Siti Thomas
Published: April 2023

Introduction: Monosodium Glutamate (MSG) increase free radicals and effecting on male reproductive hormone balance. CMCE propolis extract can be used as supplement to protect cells from free radical.Objective : To prove the effect of CMCE propolis extract to increase FSH, LH and Testosterone levels in male Wistar rats induced by MSG.Methods : This research was an experimental with post test only control group design used 18 male Wistar rats and divided into 3 groups. Each group on Control (K), P1 and P2 were induced by MSG of 140mg, then on P1 added 8,3mg CMCE propolis extract and P2 10,8mg for 21 days. Then on 22th day of blood was taken through the orbitalis sinus and serum was used for the analysis FSH, LH and Testosteron levels with ELISA method.Results : ANOVA analysis test showed significant differences each group p=0,000(p˂0,05). Post hoc LSD test showed FSH, LH and Testosterone levels in the 8,3mg dose CMCE propolis extract and 10,8mg were significant different compared with control group p=0,000(p˂0,05). CMCE propolis extract 10,8mg dose had the significantly highest effect of FSH, LH and Testosterone levels than CMCE propolis extract 8,3 mg.Conclusion : CMCE propolis extract 10,8mg/day for 21 days is proven to increase FSH, LH and testosterone levels in male Wistar rats induced by MSG.
The Correlation between Individual and Environmental Hygiene and Pioderma Incidence An Analytical Observational Study in Pyoderma Patient in Islamic Sultan Agung Hospital during the Period August to December 2010
Authors: Sutisna Iis Aisyah , Harlisa Pasid , Zulaikhah Siti Thomas
Published: April 2023

Background: Bacterial skin infection is the third most common health problem in Indonesia resulting from poor personal and environmental hygiene. The most common bacterial skin infection is the pyoderma. This study aims to find out relation between personal hygiene and environmental with the incidence of pyoderma in RSI Sultan Agung Semarang.Design and Methods: The study type was analytic observational with case control design. The sample consisted of 30 respondents RSI patients Sultan Agung for case group and 30 persons as control group is the neighbors of patients who have similar characteristics and are not suffering pyoderma. The data used are secondary data from medical records and primary data from questionnaires filled out by respondents, then the data were analyzed with chi-square and to determine the correlation power there was used a contingency coefficient test.Results: It was found that the good and the bad individual hygene for the case group were 3.3% and 66.7% respectively, while for the control group the good and bad individual hygene were 80.0% and 20.0% respectively. Chi-square test resulted in p=0,000 with contingency coefisien of 0.426. It was found that the good and the bad environmental hygene for the case group were 56.7% and 43.3% respectively, while for the control group the good and bad environmental hygene were 83.3% and 16.3% respectively. Chi-square test resulted in p=0,024 with contingency coefisien of 0.27.Conclusion: There was a significant correlation between the personal and environmental hygiene and poderma insicence at the RSI Sultan Agung with a moderate relationship between individual hygiene and weak relationship between environmental hygene (Sains Medika, 3(1):24-30).
The Level of SGOT and SGPT after The Administration of Powdered Colorant Pigment Isolated from Kesumba Kelingâ€™s (Bixa Orellana) Seed Coats An experimental study in Balb/C Mice
Authors: Suparmi Suparmi , Isradji Israhnanto , Fatmawati Dina
Published: April 2023

Background: There has been an effort to explore pigment from kesumba kelingâ€™s (Bixa orellana) seed coats for a source of natural food colorant. Consumption of pigment from kesumba keling (Bixa orellana) was assumed to cause adverse effects on heart as an important organ in detoxification or inactivation of drugs or other toxic compounds. This study conducted to determine the levels of SGOT and SGPT blood serum of mice (Mus musculus) Balb/C after administration of colorant powder pigment of B. orellana seed coatâ€™s at various concentrations.Design and Methods: The research is an experimental research with Factorial Design with 2 factors. Food Colorant Powder was made from bixin, norbixin, and crude extract pigment isolated from B. orellana seed coatâ€™s. A total of 60 male mice were divided into 10 treatment groups. Powdered colorant solution at the concentration of 0% (control), 1%, 5%, and 10% were orally administered using gavage as much as 1 ml a day for 30 days.Results: Kruskal Wallis test results shows a not significant difference SGOT and SGPT level among the groups (p > 0.05), thus consumption of colorant powder of bixin, norbixin, and the crude extract with various concentrations did not affect the SGOT and SGPT.Conclusion: Colorant powder isolated from B. orellana seed coatâ€™s has been shown to have no effect on the liver function, so it is safe as food colorant (Sains Medika, 3(1):69-77).
Fostering Medical Studentsâ€™ Leadership and Team Building Skills and Respect toward Other Health Profession through Inter-Professional Education Analysis of Its Possible Application in Indonesian Medical Schools
Authors: Lestari Endang
Published: April 2023

Inter-professional learning is becoming a very hot issue in medical education field in Indonesia nowadays. Many medical faculties carried out discussions about this topic to consider the possibility to apply the method of learning in their own faculties. This writing is a critical review of an article concerning multiprofessional learning in medical field and an analysis of its possible implications to improve the quality f medical education in Indonesia (Sains Medika, 3(1):89-101).
Effectiveness of Gentamicin and Chloramfenicol for Infant Dacryocistitis
Authors: Indrajati Christina , Handojo Norma D. , Winarto Winarto
Published: April 2023

Background: Dacryocistitis is an infection of lacrimal system due to blockage of Hasner valve by a membrane commonly found in infant. The management of dacryocistitis includes nasolacrimal massage and topical broad spectrum antibiotics since chloramfenicol and gentamicin are widely used in regional hospital primary health care in Indonesia, the effectiveness of the two antibiotics require an assessment. This study was conducted to compare the clinical and bacteriological effectiveness of gentamicin and chloramfenicol for infant dacryicistitis to describe the etiologic bacterial and its sensitivity pattern.Design and Method: A randomized control trial study included 46 patients divided equally into two groups. Group K received one drop chloramfenicol six times per day and group G receive one drop gentamicin six times per day. Both of groups received therapy for 14 days. Clinical evaluation was done on week I and week II. Microbiological evaluation was performed before treatment and at the end of week two. Criteria for clinical recovery were the disappearance of the sign and symptoms of dacryocistitis, while microbiologic recovery ruled out when there is no bacteria find out on secret and lacrimal system. Antibiotics eye drop was applied after digital massage on lacrimal system and clean the secret. Grams staining, bacterial culture and sensitivity test were performed in microbiology laboratory.Result: Clinical and microbiological recovery for chloramfenicol and gentamicin were 43.5% (p = 0.832) and 52.2% (p = 0.670) respectively. The most frequent bacteria on infant dacryocistitis were Staphylococcus aureus (45.7%) followed by Pseudomonas (21.7%), Enterobacter sp (17.4%), Escherichia coli (10.9%) and Staphylococcus epidermidis (4.3%). The sensitivity of bacteria against chloramfenicol and gentamicin was Staphylococcus aureus 57.1%, Pseudomonas aeruginosa 50%, Enterobacter sp 87.5%, Escherichia coli 40% and Staphylococcus epidermidis 100%.Conclusion: There is no significant different between chloramfenicol and gentamicin in dacryocistitis (Sains Medika, 3(2):105-111).
Errors in Interpretation of Gram Stain in The First Notification from Positive BACTEC Blood Cultures in Clinical Microbiology Laboratory of Dr. Kariadi Hospital
Authors: Maryani Maryani , Sari Desvita , Wahyutomo Ridha , Masfiyah Masfiyah
Published: April 2023

Background: Blood cultures in conjunction with the initial Gram stain of positive cultures have often been considered the â€œgold standardâ€ for the diagnosis of bacteremia. When blood cultures turn positive, the attending physicians are usually notified immediately about Gram stain findings. However, information on the accuracy of Gram staining is very limited. We examined the error of preliminary blood culture reports provided by a local laboratory in an observational study.Design and Method: This was an observational study with a cross sectional approach. In this study, 369 blood cultures were examined. The positive blood cultures (135 samples) were then examined by Gram stain. Blood cultures handled on Bactec 9050, while the Gram stain was done in standard procedure Gram. Interpretation errors of Gram stain were confirmed by cultures result.Result: During one month (April 2011) we examined 369 blood cultures which 135 are positive (36.5%). Positive blood cultures were misread for 6 (4.4%) of 135 patients, they were two read as gram positive cocci had gram negative organisms by culture which were Acinetobacter baumannii, one read as gram positive bacilli had gram negative bacilli by culture which was Klebsiella pneumoniae. One isolate read as gram negative bacilli had gram positive bacilli which was Bacillus species, while two sample read as gram negative bacilli only had polymicrobial by culture, of these one isolate grew to be Enterobacter aerogenes and Staphylococcus aureus and the other were Escherichia coli and Acinetobacter spp.Conclusion: The overall 4.4% error rate of misinterpreted Gram stains from positive blood culture bottles is relatively high, so laboratory professionals and clinical microbiologist must be aware of the potential types of error that occur (Sains Medika, 4(1):23-29).
The Correlation of Exercise and Range of Motion (ROM) on Elderly Knee Observasional Study on Elderly People in Pedurungan Semarang
Authors: Widyantoro Adhitya Putra , Rosdiana Ika , Fasitasari Minidian
Published: April 2023

Background: In aging process, decreasing of musculosceletal capabilities will reduce physical activity and excercise, as well as Range Of Motion (ROM). In order to maintain the normality of ROM, joints and muscles should be moved regularly. However many elderly people are still less physically active, due to lack of knowledge, no free time for physical activity, and lack of support from the social environment. This study aimed to determine the correlation of excercise on ROM of knee in the elderly in Pedurungan District, Semarang.Design and Method: Observastional study with a cross sectional design 80 elderly men and women were divided into 2 groups: gymnastics group in the Social Rehabilitation Unit Of Pucang Gading (n=40) and unexcercises group in the Penggaron village (n=40). In both groups, the degree of ROM of knee was assessed using the Goniometer. To evaluate the value of its significance, the data were analyzed using the Mann Withney test followed by Spearmannâ€™s rho test.Result: ROM for gymnastic(exercised group) and unexercised group were 115.50Â°Â±11.591Â°, 95.38Â°Â±12.780Â° respectively with p<0. 001. Resuts showed that doing exercise was useful for maintaining ROM of knee in elderly people. Spearmannâ€™s rho test resulted in a strong correlation between ROM and exercise with r value of 0.652.Conclusion: exercise correlates with ROM of knee in elderly (Sains Medika, 4(1):39-45).
Effect of Vitamin E Tocotrienol and Its Combination with Ascorbic Acid to Types of Leukocytes White Rat (Rattus norvegicus L.)
Authors: Lestariningrum Nur Auliani , Karwur Ferry Fredy , Martosupono Martanto
Published: April 2023

Background: Immunity is not separated from the role of leukocytes with various types and functions. Tocotrienol is one of the vitamin E group of compounds with antioxidant properties which to play an important role in cell repair. The aims to determine how much of the effect of vitamin E tocotrienols and its combination with ascorbic acid on the types of leukocytes.Design and Method: Preparation of blood lear dosage edge is a technique used to determine the effect of treatment between types of leukocytes. The design of experiment was conducted with three treatment that feed intake vitamin E tocotrienols and ascorbic acid and their combination with the control and 3 repetitions. Quantitative data leukocyte counts obtained by calculating the percentage of each type of leukocytes in each treatment group and the mean of the data obtained compared with normal leukocyte counts. In addition, the data is processed by the leukocyte counts of variance test using a completely randomized design (CRD) and BNT level of 5% to determine the differences between treatments.Result: The administration of vitamin E tocotrienols and its combination with ascorbic acid influenced significantly (P> 0.05) to increase the neutrophil are 31.66% and 33.66%, 24.33% and 22.33% respectively, when compared with controls. On the other hand, there is a decrease in the percentage of lymphocytes are 26.66% and 29.16%, 19.50% and 17.00% respectively, when compared with controls. Vitamin E tocotrienols and combined with ascorbic acid did not give significant effect (P <0.05) the percentage of eosinophils, basophils and monocytes.Conclusion: The administration of vitamin E tocotrienols and its combination with ascorbic acid to give effect to the increase in neutrophils (Sains Medika, 4(1):46-56).
Efficacy Assessment of Lemon Peel Aromatherpy Againts Airborne Bacteria Experimental Study in ICU Room of Sultan Agung Islamic Hospital Semarang
Authors: Sari Merin Awu , Masfiyah Masfiyah , Chodidjah Chodidjah
Published: April 2023

Background: Healthcare associated infections (HAI) are infections acquired in health care centers such as hospital, clinic or other health care sites due to microorganisms. Research conducted by WHO showed 3-10% of all patients treated in hospitals were victims of HAI and 90% were mainly caused by bacteria, the rest by viruses, fungi or protozoa. Lemon peel aromatherapy is one of the essential oils from plants having antimicrobial activity and are beneficial to health reducing bacterial growth by inhibiting the function of cell membranes. This study aimed at evaluating the efficacy of lemon peel aromatheraphy againts airborne bacteria.Design and Method: This experimental study used post test only control groups design. The number of airborne bacteria colonies obtained from ICU room of Sultan Agung Islamic Hospital Semarang treated with lemon peel aromatherapy at the concentration of 100 % and the control group (-).The data were analyzed for normality using Shapiro Wilk followed by independent T-test Result: independent inT-test Independent showed a significant differences in the number of bacterial colonies between the treated groups receiving 100% concentration of lemon peel aromatherapy and control group (-) (p < 0.045).Conclusion: Aromatherapy extracts of lemon peel has effect on reducing the number of airborne bacteria in the ICU of Sultan Agung Islamic Hospital Semarang (Sains Medika, 4(1):71-77).
Cost-Effectiveness Analysis of Combined Use of Oral Antihypertensive Outpatient Hypertension in Regional General Hospital Tugurejo Semarang Period 2007
Authors: Timur Willi Wahyu , Andayani Tri Murti , Aribawa Riyanta
Published: April 2023

Background: Analysis of cost-effectiveness is an analysis which comparing therapy effective with its cost. In this research, therapies effective are compared between combination of oral anti-hypertension with cost that paid by patient. This research aims to identify the combination of oral anti-hypertension, which cost is the most costeffective on hypertension patient in RSUD Tugurejo Semarang, period 2007.Design and Methods: This research was a non-experimental using descriptive non-analytic, data collection performed in retrospective from medical record of patient of hypertension in RSUD Tugurejo Semarang, period 2007. Research subject was hypertension patient, which used two combinations that were anti-hypertension and using similar anti-hypertension, at least during 3-month period. Hypertension effective measured by calculating patient amount that blood pressure achieved the target during 2 month, after therapy performed. Cost effectiveness seen based on average cost-effectiveness ratio (ACER) value.Results: The result of analysis of cost-effectiveness using anti-hypertension on hypertension patient in RSUD Tugurejo Semarang, period 2007 for 44 cases has fulfilled the criterion. Female patients were 25 cases and male patients were 19 cases. The most used combination of oral anti-hypertension was class combination of diuretic-ACEI (angiotensin converting enzyme inhibitor) for 36,36%. Cheapest direct medical cost wascombination of ACEIâ€“Beta blocker for Rp. 23.250,10. The biggest therapy effectiveness there was at combination of ACEI â€“diuretic for 46,88%.Conclusion: The most cost-effective is ACEI â€“ diuretic with ACER value for 623,06 (Sains Medika, 4(2):124-133).
The Potency of Bixa orellana Seedcouts Extractâ€™s as Antiimflamation Drug
Authors: Hussaana Atina , Suparmi Suparmi
Published: April 2023

Background: Bixin is an orange-yellow carotenoid derived from the outer seed coats of annatto (Bixa orellana L.), which antioxidant activity. However, the use of this colorant in drug potency as antiimflamatory have been explored yet. The effect of crude extract from the outer seed coats of annatto on the inflammatory was investigated to determine its antiimflamation potency.Design and Method: This study was post test only control group design. Twenty four mice is selected randomly then divided into four groups, KI (extract 0.09 mg), K.II (extract 0.18 mg dose), K.III (aspirin 90 mg), and K.IV (CMCNa 0.125%). Oedema volume was measured before injection karagenin 1%, two, 2.5, three and four hours after injection karagenin. The mean reduction in inflammation were tested by one way anova and pos hoc LSD. Result: Greatest reduction in inflammation indicated by K.III (0.100 ml), then in K.II (0.067 ml), KI (0.072 ml), and lowest in K.IV (-0.017 ml). Differences in the reduction of inflammation significantly different between KI and K.II K.IV; and K.III whereas no significant difference was found between KI and K.III K.II.Conclusion: The extract of the outer seed coats of annatto (Bixa orellana L.) have antiimflamantory activity in mice that was induced by karagenin 1% (Sains Medika, 4(2):134-141).
Effect of Ginger Juice Water on Blood Glucose Levels and Histopathology of Pancreatic Beta Cells Experimental Studies on Alloxan Induced Wistar Male Rats
Authors: Djaman Qatthrunnada , Goenarwo Edijanti , Mashoedi Imam
Published: April 2023

Background: Hyperglycemia is one of the signs of diabetes mellitus, the disease is still being suffered by the people of Indonesia. Oral antidiabetic drugs mostly give unwanted side effects, then the experts developed a system of traditional medicine for diabetes mellitus. The research aimed to determine the effect of ginger juice on blood glucose levels and histopathological of pancreatic beta cells in male wistar rats induced by alloxan.Design and methods: An experimental study with a post-test only control group design, the study subjects white male wistar rats. Rats were divided into 5 groups, each group consisted of 5 rats, the group I was the control group (no treatment), group II is diabetic group (negative control), group III is Ginger + diabetes group, diabetes group is a group IV + Ginger + glibenclamide at a dose of each half, the group is the group of diabetic + V Glibenklamid.Results: The mean blood glucose levels were highest 172.02 ± 21.40 mg / dl is the K II. Lowest mean glucose levels were 112.72 ± 14.49 mg / dl for KV. Score the highest rates of pancreatic beta cell damage that is at the K II, while the lowest in the K V. Conclusion: Ginger Juice effect on blood glucose levels alloxan-induced rats. Ginger juice histopathologic effect on pancreatic beta cells alloxan-induced rats (Sains Medika, 4(2):165-173).
Relationship between Family History of Hypertention and Autonomic Nervous System Activity
Authors: Ambasari Rika Putri , Sarosa Hadi , Muhtarom Muhtarom
Published: April 2023

The most common hypertension is essential hypertention influenced by genetic factors. Autonomicic nervous activity is influenced by several factors including genetic. This study aimed to determine the relationship between family history of hypertension and autonomic nervous system activity. In this observational analytic cross sectional study, out of 124 a students of the Medical Faculty, University Islam Sultan Agung Semarang 44 students were included using simple stratified method consisting of 22 men and 22 women aged over 20 years. The subjects were asked for family history of hypertension, orthostatic and valsalva examination. 25 students (56.8%) had a family history of hypertension and experienced imbalance of autonomic nervous activity. Out of 19 students (43.2%) without a history of hypertension, 10 people (22.7%) had a balance of autonomic nervous system activity and 9 people (20.5%) experienced imbalance of autonomic nervous system activity. Fisher correlation test results showed a significant association (p < 0.05) and correlation test of Lamda resulted in p value of 0.100, indicating a very week positive correlation. The study concludes that there was a correlation between a family history of hypertension and on autonomic nervous system activity with a very weak relationship.
The Effect of Alium Satium Extract on the Glomerular Diameter of STZ -induced Sprague dawley Rats
Authors: Susilorini Susilorini , Indrayani Ulfah Dian , Soffan Moch.
Published: April 2023

Hyperglycemia exert toxic effect in kidney.The aim of this study was to investigate the short term effect of ethanolic extract of garlic in preventing nephropathy following streptozotocin (STZ) induced rats. Twenty male Sprague dawley rats were randomly divided into 4 group, all group induced induced by single dose intraperitoneal injection of 40 mg kg-1 of streptozotocin (STZ). Treatment with 3 doses ethanolic extract of garlic (0,1; 0,25; 0,5 mg kg-1 day-1) was followed for 14 days, then the left kidneys were excised and histhopathological studies were carried out using scanner 3D Hitech and Panoramic view software. Statistical analysis have been done using non parametric analysis Kruskall Wallis. The study revealed that glomerular diameter of the treatment rats was significantly different from the control group (p=0,0001). Increasing doses didnâ€™t make difference. The ethanolic extract of garlic (Allium sativum) influences the diameter glomeruli but increasing doses has no effect on the glomerular diameter.
Relationship between Risk Factors and Drug Use among Female Prisoners in Semarang Prison between 2012 and 2013
Authors: Ahmadi NH Ahmadi NH , Fitri Ratna , Elly NH Elly NH
Published: April 2023

Drugs abuse is a complex problem facing family and society. Drug abuse cases have long long been recognized. in Indoneisia the cases started to gain public attention in 1969. Today, the similiar cases are increasing in number. There have been more number cases and type of drugs abused (multiple drugs). The Risk factors for drug abuse vary among individuals and involve several factors namely individual, environment and drugs. The interaction of the three factors leads to the drug abuse. To cope with that, a holistic approach is needed. This study was aimed at dinding out the risk factors for drug abuse among women serving in women prison of Semarang due to drug abuse. In this cross-sectional study, chi square test was applied to assess the correlation between the risk factors and the drug abuse. Cooficient contigency was applied to evaluate the degree of correlation among variables. The result showed that out of 273 women prisoners, 176 were drug abusers. The individual factors of enxiety had a normal possitive correlation with drug abuse with a weak correlation (p<0,05, r=0,221.)
Effect of Tempeh Flour Supplementation During Pregnancy In Wistar Rats With Limited Diet
Authors: Wibowo Joko Wahyu
Published: April 2023

Free radicals are formed in the body as a by-product of an aerobic respiration. During pregnancy, the increase in free radicals potentially causes structural and functional damages to fetus. Tempeh is originally from Indonesia having various nutrition inclding vitamin, mineral and isoflaphon serving as antioxidhant having potential to reduce and improve DNA damage. This study was aimed to investigate the effect of tempeh flour suplementation during pregnancy on Glutathione peroxides (GPx) and Malondetaldehyde (MDA) as an indicator of lipid peroxide in the offspings. In this experimental study, 20 pregnant female wistar rats were devided into four groups of 5 rats each to receive one of the following treatment :10 g standard diet/rat/d, 10 g/rat/d of standard diet and tempeh flour 1. g//d, 10 g/d of standard diet and tempeh flour 2g/d, standard diet of 10 g/d and 1g of egg/d. And aquades ad libitum. During nursing period (until 1 month) the rats were fed 10 g/100gBB/d normal diet, after weining they were supplemented with a diet of high in saturated fat for 4 weeks for each group. The Mean of litter size was 1: 9.33 with mean of BW 4.93 g, group II:6.17 with BW of 5.32, group III: 5.17 with BW of 5.33, group IV: 6.33 with BW: 5.01. Means of GPx for the four groups were 22.38 U/mg, 28.94 U/mg, 38.59 U/mg, 16.98 U/mg respectively. The mean of MDA for the four groups were 11.07 nmol/mg, 9.89 nmol/mg, 10.06 nmol/mg and 12.25 nmol/mg respectively. There was a significant difference in GPx and MDA (p=0.00). In conclusion tempeh flour had an effect on the level of GPx and MDA in rats with limited diet during pregnancy.
Hypertension: Dominant Risk Factor on Stroke Occurence Analytical Observational Study in Sultan Agung Islamic Hospital Semarang during January 1, 2012 - August 31, 2013
Authors: Saputri Desia Laila Dian , Rosdiana Ika , Lestari Endang
Published: April 2023

Introduction: Stroke ranks as the first cause of disabilities and the third cause of death in the world. Many factors associated with stroke. Objective: this study aimed at evaluating the factors associated with stroke. Study Design: This study was an analytical observational study using cross sectional design. Samples were obtained from medical records of 263 patients who were admitted in neurologyâ€™s ward of Sultan agung Islamic hospital during 1 January 2012-31 August 2013. Samples categorized in 2 groups: 97 hemorrhagicâ€™s stroke patients and 166 non hemorrhagicâ€™s stroke patients with simple random sampling technique. This study were conducted by analyzing 5 variables such as gender, age, hypertension, diabetes mellitus and total cholesterol levels. Results: Logistic regression test using SPSS showed that hypertension was the most dominant factor associated with stroke (p=0.001; PR=1.707; CI=1.249â€“2.433). Conclusion: Hypertension was the most dominant risk factor for stroke.
The Correlation between Duration of Employment, Body Posture and Smoking Habit on Low Back Pain Incidence An Analytic Observational Study Among Taxi Driver in Semarang Municipality
Authors: Firmanita Syifa Dian , Rosdiana Ika , Indrayani Ulfah Dian
Published: April 2023

Introduction: Low back pain ((LBP) ranks as number two of neurological diseaseâ€™s highest prevalence after cephalgia and migraine in Indonesia. Objective: This study aim to determine the relationship between duration of employment, body posture and smoking habit on the incidence of low back pain on taxi driver. Method: This research is an observational analytic cross sectional design. Seventyfour taxi drivers in Semarang municipality was screened with Beckâ€™s Depression Inventory Scale to meet the inclusion and exclusion criteria. Respondents were then given Risk Factor of LBP questionnaire. Data were analyzed with a bivariate correlation test contingency coefficient to see the relationship between duration of employment, body posture, smoking habit and low back pain.Result: the taxi driver with duration of employment >10 years were moderate smokers and having astenis body posture. The analysis of correlation coefficients contingency test showed a significance relationship between duration of employment (p = 0,000), body posture (p = 0,000), and moderate smokers (p=0.010) with the incidence of LBP. Conclusion: the taxi driver with duration of employment >10 years with astenis body posture, and moderate smokers were posstively correlated with LBP.
Does Androgen Hormone Influences Sexual Orientation?
Authors: Nasihun Taufiqurrahman
Published: April 2023

Now days lesbian, gay, bisexual, and transgender are abbreviated as LGBT is the most popular word and being sensible in the world, especially in Indonesia. Based on human right principles, any person in the world including in Indonesia is free to express their gender identity and sexual orientation, even the same sex marriage, freely from unlawful discrimination and violations (Office of Personnel Management, 2015; Yogyakarta Principles, 2006). However, because of the culture and religion differences backgrounds, Indonesians have given this issue various responses. In general, Indonesian public opinion on LGBT are split into two different groups, one minority group is proponent to present of LGBT and any things related to it, and another majority groups are opponent. Objective of this editorial is to discuss how sexual orientation develop from prenatal until emerging of clinical manifestation in adulthood, by no mean to support either group. Otherwise, to give more insight about how male and female get their appropriate sexual orientations and why some of them get inappropriate sexual orientations.
Effect of White Turmeric Extract (Curcuma zedoaria) Using Zam-zam Solvent Compare with Ethanol Solvent Against Breast Cancer Cell T47D
Authors: Hudaya Isna , Nasihun Taufiqurrahman , Sumarawati Titiek
Published: April 2023

Introduction: Curcuma zedoaria is one of the herbal plants potentially protects and cures many diseases, particularly as anti-cancer and anti-tumor. Anti-cancer active compounds of it are flavonoid, phenolic, and saponin. Objectives: This study aimed to explore the cytotoxicity of Curcuma zedoria extract (CZE). Methods: Experimental Quasi with post test non equivalent control group design on T47D cell line at Biology laboratory, Faculty of Medicine, Sultan Agung Islamic University, Semarang. The research was consisted of 2 groups, namely: intervention group with CZE zam-zam solvent and intervention group with CZE ethanol solvent given 10 different dosages each for 1.000 Î¼g/mL; 500 Î¼g/mL; 250 Î¼g/mL; 125 Î¼g/mL; 62.5 Î¼g/mL; 31.25 Î¼g/mL; 15.62 Î¼g/mL; 7.81 Î¼g/mL; 3.90 Î¼g/mL; 1.95 Î¼g/mL. Cytotoxicity test of IC50 using direct counting method and analyzed by probit analysis. Results: IC50 value of CZE in zam-zam and ethanol solvent were 28.24 Î¼g/ml and 13.71 Âµg/ml respectively at the same 24 hours incubation period. Chi-square test revealed p value was 0.000 (Î± = 0.05), meaning that there was significant relationship. Conclusion: CZE activity using ethanol is highly active while CZE using zam-zam water is moderate and both of them have the toxicity on breast cancer cell. As the result, apoptosis process may occur.
Probiotics Effect on Interleukin-4 (IL-4) and Imunoglobulin E (IgE) Levels on Asthmatic Patients
Authors: Pujiati Pujiati
Published: April 2023

Introduction: Probiotics may play a role in immune system maturation and may reduce the risk of allergies and asthma in childhood. However, the therapeutic benefits of probiotics in asthma depend on various factors such as strain of probiotics and dosing regimen. Objectives: The aims of this study was to evaluate the effect of probiotic (LactoBÂ®) on Immunoglobulin E (IgE) and Interleukin (IL-4) serum level in childhood Asthma. Methods: Forty children aged 1-5 years with asthma were recruited into a randomized controlled trial. The children were assigned into a probiotic (Lactobacillus acidophilus, Bifidobacterium longun, Streptococcus; Lacto BÂ®) or an equivalent volume of placebo, twice daily orally for 8 weeks. The IgE and IL-4 serum level were determined by ELISA. The differences between groups were analyzed by t-test dependent with confidence interval of 95%. Results: In intervention group, mean of IgE serum levels after the probiotics treatment was significantly lower compared to that of before the treatment (148.18 pg/mg; 283.20 pg/mg; respectively). Mean of IL-4 serum levels after the treatment was significantly lower compared with that of before the treatment (111.03 pg/mg; 142.08 pg/mg respectively). In control group, there were no significant differences between IgE serum levels mean before the administration of placebo and after the intervention (292.39 pg/ml; 286.94 pg/ml respectively). There were no significant differences between IL-4 serum levels mean before and after the treatment (136.76 pg/ml; 139.56 pg/ml).Conclusion: there was an effect of probiotics supplementation on IgE and IL-4 serum levels in childhood asthma.
The Relationship between Characteristics of Cerebospinal Fluid and Tuberculous Meningitis detected using Real Time PCR
Authors: Masfiyah Masfiyah , Subakir Subakir , Kristina Tri Nur
Published: April 2023

Introduction: Tuberculosis (TB) carries a high morbidity and mortality, however, its diagnosis can be difficult due to low concentration of bacteria in the cerebrospinal fluid (CSF). Although increased CSF protein, decreased CSF glucose; cerebrospinal fluid (CSF) pleocytosis with mononuclear cells predominance are commonly used to diagnose TB infection, they show inconsistent results.Objectives: To analyze the relationship between several characteristics of the CSF and TB meningitis.Methods: This is an observational research, with a cross sectional design, 27 patients with TB meningitis and or meningoencephalitis with Thwaites diagnostic score ≤ 4 obtained from mecidal records. The definitive diagnosis of TB meningitis was made using the Ziehl Neelsen (ZN) staining and or culture TB, or polymerase chain reaction (PCR) amplification with the target in IS6110, Ziehl-Neelsen staining (ZN) culture method. Characteristics of CSF including increased CSF protein, decreased CSF glucose, cerebrospinal fluid (CSF) pleocytosis with mononuclear cells predominance and the CSF abnormalities were evaluated in the laboratory of molecular microbiology of Medical Faculty, Diponegoro University/dr Kariadi General Hospital, Semarang. The statistical analysis used was prevalent ratio (RP).Results: Over 27 patients, 12 (44.4%) were diagnosed with definite TB meningitis. Statistical analysis showed that prevalence ratio of the increased levels of protein CSF was 3.143 (95% CI: 0.502 to 19.692), decreased glucose levels was 1.750 (95% CI: 0.501 to 6.112), pleocytosis with a predominance of mononuclear cells was 2.5 (CI 95% : 1.238 to 5.048), whereas the CFS abnormality was RP 2.2 (95% CI: 1.087 to 4.454).Conclusion: This study has shown that pleocytosis with mononuclear cells predominance and CFS abnormalities have a positive relationship with definite TB meningitis.
Death in Patients with Regular Hemodialysis Due to CKD in RSUD Dr. Soedono Madiun Not Correlated to Various Risk Factors
Authors: Lumaksono Tulus , Rachmawati Anisa , Marfianti Erlina
Published: April 2023

Background: Chronic Kidney Disease (CKD) indicated by the inability of the kidneys in maintaining homeostasis of the body.1 This causes the patient to undergo renal replacement therapy for life. Patients undergoing regular hemodialysis have a higher risk of death in the last 2 decades. The survival of hemodialysis patients is different because it is influenced by several factors, including age, sex, duration of hemodialysis, duration of hemodialysis and accompanying comorbid patients.Objective: To identify risk factors that affect mortality in patients with CKD undergoing regular hemodialysis.Method: This research is an observational research with case-control design. Research done in dr.Soedono Madiun Hospital in December 2016 with a sample size of 41 cases and 41 control. Data retrieved through the medical records of patients with CKD who undergo regular HD from January to November 2016. Data analysis was performed including analysis of univariate,  bivariate analysis using chi-square test with 95% CI, 5% significance level (α = 0.05) and analysis multivariste using logistic regression.Results: There was no significant relationship between age (p = 0.23; OR = 1.78; 95% CI 0.68 to 4.64), gender (p = 0.623; OR = 1.24; 95% CI 0, 49 to 3.18), long live HD (p = 0.12; OR = 0.50; 95% CI 0.20 to 1.20), duration of HD (p = 0.81, OR = 0.89; 95% CI 0.34 to 2.28), hypertension (p = 0.21; OR = 0.44; 95% CI 0.12 to 1.61), diabetes mellitus (p = 0.17; OR = 1 , 83, 95% CI 0.75 to 4.47), hemoglobin level (p = 0.26; OR = 1.66; 95% CI 0.68 to 4.05) and intradialitik complications (p = 0.81 , OR = 1.11; 95% CI 0.44 to 2.80) with mortality in patients with CKD.Conclusion: There is no significant relationship between age, gender, length undergoing hemodialysis, duration of HD, hypertension, diabetes, hemoglobin, and complications intradialitik in CKD patients undergoing hemodialysis in dr.Soedono Madiun Hospitals.