bluuebunny/crossref_metadata_2025 huggingface dataset:
DISTRIBUTION OF THE EFFORTS OF THE MUSCLE MUSCLES HUMAN DENTAL SYSTEM AT ASYMMETRIC TONE SURFACE MASKING MUSCLES
Authors:   Candidate of Physical and Mathematical Sciences, Perm National Research Polytechnic University, Department of Computational Mathematics, Mechanics and Biomechanics, Perm, Russian Federation, Nikitin Vladislav Nikolaevich , Bushueva Natalia Leonidovna ,   Master's Student, Perm National Research Polytechnic University, Department of applied mathematics, Perm, Russia
Published: August 2021

The dentofacial system is closely related to the musculoskeletal, digestive, nervous, cardiovascular systems, etc. The functioning of the dentofacial system affects nutrition, breathing, swallowing, speech, hearing, etc., where occlusion is one of its main parameters. Many pathologies in the dentofacial system are also associated with a change in the efforts of the masticatory muscles, where hypertonicity of the superficial masticatory muscle is most common. The article considers an example of her hypertonicity by biomechanical modelling. For this, the problem of determining of the masticatory muscle efforts was solved at the maximum value of the force of compression of the jaws, which was 600 N. The cases were considered when the minimum possible value of the force of the superficial masticatory muscle was 70%, 80% and 90% of the maximum value. It was found that for the case while the minimum values of the efforts of all masticatory muscles do not exceed 50% of their maximum possible values, then the distribution of muscle efforts remains unchanged, i.e. the values of muscle efforts do not change. When at least one of the muscles exceeds its half of the maximum possible effort, it is observed that the efforts of the remaining muscles on the same side of the face decrease or remain approximately at the same level, and on the opposite side, the muscle efforts initially decrease, and at 80% and 90% of the maximum possible magnitude of the effort of the superficial chewing muscle increases again. In further works, various combinations of hypertonicity of the masticatory muscles, as well as the hypotonia of these muscles, are assumed.
MODEL AND ALGORITHMIC SUPPORT OF THE EXPERT SYSTEM «STABLE REINDEER HUSBANDRY IN THE FAR NORTH»
Authors:   NorthWest Regional Scientific Centre, Russia St. Petersburg Federal Research Center of the Russian Academy of Sciences, Pushkin, Russia, Yuzhakov Alexander Alexandrovich , Spesivtsev Alexander Vasilievich ,   Federal State Budgetary Institution of Science «St. Petersburg Federal Research Center of the Russian Academy of Sciences» SaintPetersburg Institute for Informatics and Automation of RAS (SPIIRAS), St. Petersburg, Russia, Spesivtsev Vasily Alexandrovich ,   NorthWest Regional Scientific Centre, Russia St. Petersburg Federal Research Center of the Russian Academy of Sciences, Pushkin, Russia
Published: August 2021

Reindeer is part of the humandeerpasture sociobiological system, where all the constituent parts form emergence. The differences between the reindeer husbandry of foreign countries and Russia are shown. Reindeer in various countries are considered mainly as wild, few herds, and in Russia, at present, 75% of the reindeer population in the Arctic zone belongs to the domestic form. Therefore, the approaches to the study of the problems of reindeer husbandry also differ: the studies of foreign scientists are focused on the study and construction of models of local problems, while Russian studies, in addition to important local problems, are aimed at solving the problems of analyzing the features of the entry of traditional fishing farms into the system of market relations and forms adaptation of traditions to the modern image of economic reality. However, the description of sociobiosystems refers to poorly formalized problems that do not lend themselves to modeling by deterministic mathematical methods, and even more so by statistical ones. Therefore, a new fuzzypossibility approach for constructing multifactor models is proposed, based on the use of explicit and implicit knowledge and experience of experts. An example of constructing an adequate fuzzypossibility model of the stability of a reindeer husbandry in a sevenfactor space of both quantitative and nonquantitative (qualitative) variables is given. The adequacy of the model was confirmed situationally for the state of three reindeerbreeding commercial farms in the YamalNenets Autonomous Okrug for 2019 and 2020.
ASSESSMENT OF RELATIONSHIP BETWEEN KEY INDICATORS OF SUSTAINABLE DEVELOPMENT OF OIL COMPANIES IN AN UNSTABLE ECONOMY
Authors:   Candidate of Economic Sciences, Professor of the Department of Economic Analysis and Financial Monitoring in the Institute of Integrated Safety and Security and Specific Instrumentation in MIREARussian Technology University, Moscow, Russian Federation, Kuzovleva Nina Fedorovna , Prokofieva Lyudmila Mikhailovna ,   Candidate of Geology, Associated Professor of Economics of Mineral Resources Complex Department Russian state geological prospecting University named after S. Ordzonikidze, Moscow, Russian Federation, Simakova Diana Evgenyevna ,   Student, Institute of Integrated Safety and Security and Specific Instrumentation in MIREARussian Technology University, Moscow, Russian Federation
Published: August 2021

This paper is devoted to analysis of the relationship between the level of company's capitalization and individual indicators which characterize sustainable development – replenishment of petroleum commodities as a result of geological exploration, labor productivity and frequency of accidents. The authors have made an attempt to determine the closeness of the relationship of these indicators using correlation and regression analysis. Current materials of financial and nonfinancial reports on levels of indicators of PJSC LUKOIL for the period 2015–2019 were used as input information.
Monte Carlo Prediksi Tingkat Prevalensi Stunting Kabupaten Lima Puluh Kota Menggunakan Metode Monte Carlo
Authors: Zaimy Mike , Defit Sarjon , Nurcahyo Gunadi Widi
Published: August 2021

Stunting merupakan kondisi gagal tumbuh pada anak balita (bayi di bawah lima tahun) akibat dari kekurangan gizi kronis sehingga anak terlalu pendek untuk usianya. Menurut data yang ada, angka prevalensi stunting di Kabupaten Lima Puluh Kota tahun 2020 cukup tinggi yakni sebesar 8,28%. Hal ini menjadi perhatian pemerintah pusat dengan menetapkan Kabupaten Lima Puluh Kota sebagai salah satu Kabupaten/Kota Lokasi Fokus Intervensi Penurunan Stunting Terintegrasi Secara Nasional. Hasil penelitian ini bertujuan untuk membantu Pemerintah Kabupaten Lima Puluh Kota dalam perencanaan konvergensi program/intervensi sebagai salah satu upaya percepatan pencegahan stunting dan menurunkan persentase balita stunting di Kabupaten Lima Puluh Kota. Data penelitian ini menggunakan angka prevalensi stunting dari tahun 2018 sampai tahun 2020 yang berasal dari data jumlah balita dan jumlah balita stunting dari 22 puskesmas yang berada di Kabupaten Lima Puluh Kota. Selanjutnya data tersebut diolah menggunakan metode Monte Carlo untuk memprediksi tingkat prevalensi stunting tahun 2021. Berdasarkan pengujian yang dilakukan menggunakan metode Monte Carlo, didapatkan hasil tingkat prediksi stunting yang tertinggi berada pada puskesmas Pakan Rabaa dan puskesmas Suliki dengan angka prevalensi stunting sebesar 11,70%. Adapun tingkat akurasi yang diperoleh sebesar 93,73 %. Metode Monte Carlo cocok digunakan untuk prediksi angka prevalensi stunting di Kabupaten Lima Puluh Kota dilihat dari tingkat akurasinya yang cukup tinggi dari hasil pengolahan data.
Bank Deposit Prediction Using Ensemble Learning
Authors: Patwary Muhammed J. A. , Akter S. , Bin Alam M. S. , Rezaul Karim A. N. M.
Published: August 2021

Bank deposit is one of the vital issues for any financial institution. It is very challenging to predict a customer if he/she can be a depositor by analyzing related information. Some recent reports demonstrate that economic depression and the continuous decline of the economy negatively impact business organizations and banking sectors. Due to such economic depression, banks cannot attract a customer's attention. Thus, marketing is preferred to be a handy tool for the banking sector to draw customers' attention for a term deposit. The purpose of this paper is to study the performance of ensemble learning algorithms which is a novel approach to predict whether a new customer will have a term deposit or not. A Portuguese retail bank data is used for our study, containing 45,211 phone contacts with 16 input attributes and one decision attribute. The data are preprocessed by using the Discretization technique. 40,690 samples are used for training the classifiers, and 4,521 samples are used for testing. In this work, the performance of the three mostly used classification algorithms named Support Vector Machine (SVM), Neural Network (NN), and Naive Bayes (NB) are analyzed. Then the ability of ensemble methods to improve the efficiency of basic classification algorithms is investigated and experimentally demonstrated. Experimental results exhibit that the performance metrics of Neural Network (Bagging) is higher than other ensemble methods. Its accuracy, sensitivity, and specificity are 96.62%, 97.14%, and 99.08%, respectively. Although all input attributes are considered in the classification method, in the end, a descriptive analysis has shown that some input attributes have more importance for this classification. Overall, it is shown that ensemble methods outperformed the traditional algorithms in this domain. We believe our contribution can be used as a depositor prediction system to provide additional support for bank deposit prediction.
Beyond the Tourist Experience: Analyzing the Imagination of Place and Travel in Everyday Life
Authors: Reijnders Stijn , Boross Balazs , Balan Victoria
Published: August 2021

This article advocates a new agenda for (media) tourism research that links questions of tourist experiences to the role and meaning of imagination in everyday life. Based on a small-scale, qualitative study among a group of 17 respondents of diverse ages and backgrounds currently residing
in the Netherlands, we offer an empirical exploration of the places that are of importance for people's individual state of mind and investigate how these places relate to (potential) tourist experiences. The combination of in-depth interviews and random-cue self-reporting resulted in the
following findings: 1) all our respondents regularly reside in an elaborate imaginary world, consisting of both fictional and nonfictional places; 2) this imaginary world is dominated by places that make the respondents feel nostalgic; 3) in this regard, the private home and houses from childhood
are pivotal; 4) the "home" is seen as topos of the self and contrasted with "away"; 5) the imagination of "away" emerges from memories of previous tourist experiences, personal fantasies, and, last but not least, influences from popular culture. We conclude that imagining and visiting other
locations are part of a life-long project of "identity work" in which personal identities are performed, confirmed and extended. By traveling, either physically or mentally, individuals anchor their identity—the entirety of ideas about who they are, where they come from, and where they
think they belong—in a broader, spatial framework.
"What Your Head!": Signs of Hospitality in the Tourism Linguistic Landscapes of Rural Japan
Authors: Doering Adam , Kishi Kurara
Published: August 2021

This article explores signs of hospitality in the tourism linguistic landscape (LL) of the Kumano Kodo Pilgrimage Trail in Wakayama, Japan. We argue that the multilingualization of visible tourism public signage in this rural region raises important philosophical questions of hospitality.
With the help of Jacque Derrida to navigate this terrain, we examine how rural communities communicate and negotiate hospitality in a rapidly internationalizing rural tourism destination. Combining photographic data, participant observation, and open-ended interviews, we offer a close reading
of the tourism LL at three gathering points along the Nakahechi route: Shingu City station, Kumano Hongu Taisha, and the small village of Chikatsuyu. The article is structured as follows. We begin by defining LL studies and draw attention to the current research in tourism settings. Next,
an overview of Derrida's contribution to the philosophy of hospitality is presented, which acts as a guide for reading the trail's tourism LL. The discussion then revolves around three main themes: the host as hostage to hospitality; the reproduction of the conditional hospitality through
tourism LL; and the work of hospitality understood as an ethic of negotiating the threshold of the unconditional and conditional, the impossible and the unavoidable. Bringing together a philosophy of hospitality with tourism LL research, the article adds new theoretical perspectives
to the study of LL. It also deepens our understandings of the relationship between hospitality, tourism, and linguistic landscapes.
Employee Work Behavior in Creative Industries
Authors: Savitri Nilasari , Phelia Anisya , Iskandar Amir , Maharani Anita
Published: August 2021

This study aims to determine the effect of thinking style, integrity, and meaning of work on counterproductive work behavior in creative industries. The concept in explaining phenomenon start from elaboration from each of the keywords mentioned: thinking style, integrity, work meaning, and counterproductive behavior. The research method used in this research is explanatory research. The data used are primary. The population in this study is the entire creative industry sector in Indonesia. This research model is multivariate using SPSS as an analytical tool in this research. The results showed partially and simultaneously that the style of thinking, integrity, and meaning of work did not affect counterproductive behavior. So we can conclude that this study shows that if there is counterproductive behavior in employees in the creative industry who have a more open-minded pattern but no influence from thinking style, integrity, and work meaning.
Role of estrogen receptor coregulators in endocrine resistant breast cancer
Authors: Altwegg Kristin A. , Vadlamudi Ratna K.
Published: August 2021

Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70-80% of BC diagnoses are positive for estrogen receptor (ER) alpha (ERα). The steroid hormone estrogen [17β-estradiol (E2)] plays a vital role both in the initiation and progression of BC. The E2-ERα mediated actions involve genomic signaling and non-genomic signaling. The specificity and magnitude of ERα signaling are mediated by interactions between ERα and several coregulator proteins called coactivators or corepressors. Alterations in the levels of coregulators are common during BC progression and they enhance ligand-dependent and ligand-independent ERα signaling which drives BC growth, progression, and endocrine therapy resistance. Many ERα coregulator proteins function as scaffolding proteins and some have intrinsic or associated enzymatic activities, thus the targeting of coregulators for blocking BC progression is a challenging task. Emerging data from in vitro and in vivo studies suggest that targeting coregulators to inhibit BC progression to therapy resistance is feasible. This review explores the current state of ERα coregulator signaling and the utility of targeting the ERα coregulator axis in treating advanced BC.
The Effects of Cervical Stabilization Exercises with Breathing Exercises on Respiratory Function in Subjects with Forward Head Posture
Authors: Yu Lijun , Gu Qian , Kim Taeho
Published: August 2021

This study aimed to compare the effects of cervical stabilization exercises with breathing exercises and cervical stabilization exercises with thoracic spine extension exercises on respiratory function in subjects with forward head posture (FHP). The study included 30 adults with FHP. They were divided into two groups—experimental (EG) and control (CG)—with 15 participants in each group. The EG was asked to perform cervical stabilization exercises with breathing exercises, and the CG was asked to perform cervical stabilization exercises with thoracic spine extension exercises. After 4 weeks of exercise, the changes in respiratory function were measured again. The results showed significant differences in the EG before and after exercise in terms of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced vital capacity/vital capacity max (FVC/VCmax%) (p < 0.05). The CG showed only a significant increase in FVC, FEV1, and FVC/VCmax% after the experiment (p < 0.05). In the between-group comparison, there were significant differences noted in FVC, FEV1, PEF, and FVC/VCmax% in the EG compared to the CG (p < 0.05). As a result, cervical stabilization exercises with breathing exercises are recommended to promote respiratory function.
Local antiviral activity of the drug «Thymogen®», nasal dosed spray, against SARS-CoV-2 coronavirus in vitro
Authors: Leneva I. A. , Smirnov V. S. , Kudryavtseva T. A. , Fayzuloev E. B. , Gracheva A. V. , Kartashova N. P. , Zaplutanov V. A. , Petlenko S. V.
Published: August 2021

On account of the COVID-19 pandemic, the global pharmaceutical industry has achieved impressive results in the development and introduction of various types of vaccines causing the formation of acquired immunity against the SARS-CoV-2 coronavirus into clinical practice. However, none of them currently show the declared one hundred percent guarantee of protection. In the case of the COVID-19 disease, patients with concomitant pathologies are the most vulnerable to the occurrence of severe complications. The aerosol route of transmission of SARS-CoV-2 contributes to the emergence of outbreaks of the new coronavirus infection in crowded places and closed rooms with poor ventilation. In this regard, an urgent problem is the search for drugs with local antiviral activity, which, together with restrictive measures and mask wearing policy, can potentially reduce the likelihood of contracting coronavirus. In this experimental in vitro study on Vero CCL81 cell culture (ATCC), the local antiviral activity of the drug Thymogen® spray against the SARS-CoV-2 virus was studied in comparison with the antiseptic Miramistin® solution. As a result of the experiment, no toxic effects on Vero cells were detected in the drugs in the studied concentrations. In a series of experiments, Thymogen® spray showed local antiviral activity against SARS-CoV-2 when the virus titer was 5,2 lg TCID50. Therefore, the drug Thymogen® dosed nasal spray has high potential as a topical drug for prevention and treatment of COVID-19 disease, which requires additional confirmation in relevant clinical studies.
Immunoadjuvant activity of marine bacteria exopolysaccharides in normal and immunosuppressive conditions
Authors: Kuznetsova T. A. , Persiyanova E. V. , Ivanushko L. A. , Smolina T. P. , Gazha A. K. , Kokulin M. S. , Besednova N. N.
Published: August 2021

Aim. To assess the mechanisms of immunoadjuvant activity of marine bacteria exopolysaccharides (PS) in normal and immunosuppressive conditions in vivo. Material and methods. Experimental studies were carried out on male ВALB/c mice, immunized with compositions of PS or aluminum hydroxide and ovalbumin (OVA). Immunosuppression was induced by triple intraperitoneal administration of dexamethasone (2 mg/kg). Serum levels of speciﬁc antibodies (IgG, IgG1, and IgG2a) and cytokines (IFN-γ, IL-2, IL-10) were determined. Results. The inclusion of PS to the immune compositions led to the formation of an enhanced speciﬁc IgG, IgG1, and IgG2a to OVA, comparable to the eﬀect of aluminum hydroxide. The studied PS also contributed to an increase in the level of both pro- and anti-inﬂammatory cytokines. Conclusion. PS from marine bacteria act as adjuvants in normal and immunosuppressive conditions, stimulating a mixed Th1 (IgG2a, INF-γ) and Th2 (IgG1, IL-10) immune response to OVA.
Correlation of quantitative measures of estrogen receptor α and β expression in non-small cell lung cancer tissue with clinical characteristics of the disease
Authors: Bogush T. A. , Samsonik S. A. , Basharina A. A. , Bogush E. A. , Ryabinina O. M. , Grishanina A. N. , Kirsanov V. Yu. , Karpukhin A. V. , Kosorukov V. S.
Published: August 2021

The expression level of estrogen receptors (ERα and ERβ) in surgical tumor biopsy specimens from 167 patients with non-small cell lung cancer (NSCLC) was quantiﬁed by ﬂow cytometry-based immunoﬂuorescence analysis. ERα and ERβ expression was revealed in all the tumor samples investigated. The level of ERα expression in the tumors varied from 10 to 58% and ERβ — 12% to 80%, indicating signiﬁcant heterogeneity of estrogen receptor expression in tumors of diﬀerent patients. The mean ERβ expression level was approximately 2-times higher compared to ERα (42.1±15.3% vs 21.4±11.3%; p<0.001). It allows to consider ER>β as a major estrogen target in NSCLC tissue. The level of ERα and ERβ expression in NSCLC tissue is independent of gender, smoking status, and the histological type of the tumor. Increased ERβ expression was detected only in male patients with lung adenocarcinoma in comparison with squamous cell carcinoma (p=0.02). The assessment of the correlation between ERα and ERβ in both the whole cohort of patients and subgroups with clinically relevant disease parameters revealed that the level of one marker does not predict the other one’s expression. The coeﬃcient of determination, which characterizes how diﬀerences in one variable can be explained by the diﬀerence in a second variable, was less than 25% in any comparison group. The authors consider that the high level of ERβ expression and ERα coexpression in NSCLC tissue substantiates the clinical perceptiveness of a new treatment option for the disease, namely, adjuvant hormone (antiestrogen) therapy.
Meta-analysis of randomized controlled clinical trials of Riamilovir eﬃcacy in the etiotropic therapy of acute respiratory viral infection
Authors: Sabitov A. U. , Kovtun O. P. , Batskalevich N. A. , Maltsev O. V. , Zhdanov K. V. , Esaulenko E. V. , Tikhonova E. P. , Kalinina Yu. S. , Sorokin P. V. , Chepur S. V. , Stepanov A. V.
Published: August 2021

The aimof the study was to carry out meta-analysis of randomized controlled trials in order to combine the results of clinical trials on Triazavirin®(Riamilovir) eﬃcacy in the etiotropic therapy of acute respiratory viral infection.Materials and methods.The studies included 435 patients with a conﬁrmed diagnosis of acute respiratory viral infection or ARVI (with laboratory conﬁrmed absence of inﬂuenza virus antigens). The research was carried out in 27 centers. In studies, patients were divided into 3 groups in a 1:1:1 ratio (a total of 145 people per group). Each study included a group taking 100 mg of the medication 5 times a day, a group taking 250 mg of the medication 3 times a day and a placebo 2 times a day, as well as a group taking a placebo 5 times a day. The analysis was carried out in accordance with the PRISMA principles regarding the quality of information presentation on the results of systematic reviews and meta-analyzes of works evaluating the effects of medical interventions.Results. The conducted meta-analysis showed that the use of Triazavirin®(Riamilovir) has a statistically signiﬁcantly eﬀects on the severity of clinical symptoms in patients with ARVI. The performed meta-analysis conﬁrmed reliable associations between the use of Triazavirin®(Riamilovir) in both doses and the chance of a persistent improvement in clinical symptoms on the 5thday of therapy. The meta-analysis also conﬁrmed the statistical signiﬁcance of the clinical eﬀects of Riamilovir by such indicators as the area under the curve «point on the scale showing the severity of the condition in a patient with ARVI in relation to time», the proportion of patients with complete alleviation of all symptoms by the end of the 5th day from the start of therapy.Conclusion.The clinical trials proved that the use of Triazavirin®(Riamilovir) is eﬀective both in the initial and in the late stages of the disease, therefore, the drug can be used in the initial therapy of adult patients with respiratory diseases of viral etiology.
Meta-analysis of randomized clinical trials of Riamilovir eﬃcacy in etiotropic therapy of inﬂuenza
Authors: Sabitov A. U. , Kovtun O. P. , Batskalevich N. A. , Lvov N. I. , Zhdanov K. V. , Esaulenko E. V. , Tikhonova E. P. , Kalinina Yu. S. , Sorokin P. V. , Chepur S. V. , Stepanov A. V.
Published: August 2021

The aim of the study was to carry out a meta-analysis of randomized clinical trials in order to combine the results of clinical trials on Triazavirin® (Riamilovir) eﬃcacy in etiotropic therapy of inﬂuenza.

Materials and methods. The analysis was carried out in accordance with the PRISMA principles regarding the quality of information presentation on the results of systematic reviews and meta-analyzes of works assessing medical interventions. The study included 471 patients with a conﬁrmed diagnosis of inﬂuenza (with laboratory conﬁrmed presence of inﬂuenza virus antigens).

Results. The conducted meta-analysis showed that the use of Triazavirin® (Riamilovir) has a statistically signiﬁcant eﬀect on the severity of clinical symptoms in patients with inﬂuenza, therefore Riamilovir can be used in the initial therapy of adult patients with inﬂuenza.

Conclusion. Clinical studies have shown that the use of Triazavirin® (Riamilovir) is eﬀective both in the initial and late stages of the disease, and therefore Riamilovir can be used in the treatment of adult patients with respiratory diseases of viral etiology, in particular, those diagnosed with inﬂuenza. The meta-analysis of the collected data showed that therapy with Triazavirin® (Riamilovir) has statistically signiﬁcant advantages in various aspects both in comparison with the placebo group and with the Tamiﬂu® (Oseltamivir) group.
Nachhaltiges Bauen in der Praxis: Bewertung des Zertifizierungsprozesses der ökologischen Qualität nach DGNB System/Sustainable building in practice: evaluation of the certification process of environmental quality according to the DGNB system
Authors: Wuth Jasmin , Scope Christoph
Published: August 2021

Das DGNB System im Neubau hat den Anspruch eine ganzheitliche Beurteilung eines Gebäudes im Sinne des nachhaltigen Bauens sicherzustellen. Dieser Artikel untersucht, welche Hemmnisse aus Sicht der DGNB Auditoren im Rahmen des Zertifizierungsprozesses zur Bewertung der ökologischen Qualität auftreten können. Experteninterviews mit drei Auditoren bilden die Basis für einen strukturierten Fragebogen, der an alle im Jahre 2020 registrierten DGNB Auditoren verschickt wurde. Während die Interviews der explorativen Identifizierung und Systematisierung von Störfaktoren dienen, prüft der Fragebogen empirisch, inwieweit sich diese auf den zeitlichen Verlauf der Zertifizierung und das Erlangen der höchstmöglichen Bewertungspunktzahl auswirken. Die Ergebnisse zeigen, dass überwiegend mittlere bis große Hemmnisse existieren, die sowohl eine Verzögerung verursachen als auch die Gesamtpunktzahl reduzieren. Als entscheidendste gehen die Schnittstellenkooperation und ein später Integrationszeitpunkt des DGNB Konzeptes in der Neubauplanung hervor. Der Artikel suggeriert, dass eine frühzeitige Einbindung des DGNB Auditors maßgeblich die Umsetzung des nachhaltigen Bauens in der Praxis beeinflusst.
Sustainable development and industrial enterprises competitiveness increasing in the Barents Euro-Arctic region.
Authors:   Research Institute “Environmental Industrial Policy Center”, Skobelev Dmitry O. , Fedoseev Sergey V. ,   Luzin Institute for Economic Studies of the Kola Science Centre of the RAS
Published: August 2021

The article considers possibilities for increasing competitiveness of Russian industrial enterprises during the development of resource effective industrial policy. The authors discuss the meaning and interpretation of “sustainable development” and “competitiveness” used in national and international scientific publications. The article traces current trends in the external environment that can contribute to organization's competitive advantages or cause the stability loss. The most significant changes include: the strengthening of industrial policy at national and international levels; broadening the understanding of essence and geographic scope of regulation based on the principles of best available techniques; promoting resource efficient and low-carbon technologies and formulating new international marketing segment for such technologies; establishing approaches for circular economy and links to resource efficient and low-carbon development; developing responsible investment system supporting activities related to meeting sustainable development goals.The authors analyse the basic principles of Environment Social Governance (ESG) and Business Charter for Sustainable Development and demonstrate their impact on the development of new competition rules.The paper presents results of case studies carried out in pulp and paper production and mining industry: environmental and technological modernizationprojects of JSC “Kovdor Mining and Benefication Plant” and JSC “Mondi Syktyvkar” and compares these projects with theESG investment principles. The procedure for excluding Russian installations from the list of environmental “hot spots” of the Barents Euro-Arctic Region is analysed and project assessment results meeting requirements of Best Available Techniques and responsible investment are considered. The paper concludes with the statement that in order to increase the level of international competitiveness of Russian industries it is necessary to take into account sustainable development principles and ESG principles while developing environmental and technological modernization programmes of Russian enterprises.
Assessment of opportunities for the development of Arctic communications in the area of the Northern Sea Route.
Authors:   Luzin Institute for Economic Studies of the Kola Science Centre of the RAS, Ivanova Medeya V.
Published: August 2021

New plans for the development of the Russian Arctic caused certain reactions from both the external and internal environment. In March 2018, the President of the country announced new guidelines for the development of the Northern Sea Route (NSR). The documents for the strategic development of the Arctic zone of the Russian Federation were asserted. One of the main directions in these documents is the development of the NSR as a competitive national transport means of communication of the Russian Federation on the world market. As a part of the research, the political and economic aspects of the external environment were studied, which affect the development and functioning of Arctic communications in the water area of the NSR. The informational basis was provided by expert assessments of scientists and politicians, as well as by publications of news outlets and experts’ interviews. The specificity of the institutional legal field of the NSR is considered. The article reveals the phenomena of "Arctic dualism" caused by the clash of national and international law, when changes in the national legal field lead to a response from other Arctic states and an increase in political risks related to increased competition. The main business trends in the development of the NSR were also identified. The period considered in the article is characterized by the strengthening of the domestic economic policy of Russia, which is aimed at enhancing business processes in the Arctic zone of the Russian Federation. At the same time, the considered trends within the external environment indicate a number of restrictions for the use of the NSR as an international transit highway. The processes considered indicate that in the near future, the use of the NSR can only be considered in the context of meeting the industrial needs of the Arctic business.
Formation of a system of indicators for assessing the implementation of the circular economy concept in the regions of the Russian Federation.
Authors:   Graduate School of Economics and Engineering, Peter the Great St. Petersburg Polytechnic University, Gutman Svetlana S. , Manakhova Maria S. ,   Graduate School of Economics and Engineering, Peter the Great St. Petersburg Polytechnic University
Published: August 2021

The transition to the principles of a circular economy in the Russian Federation will contribute to the achievement of sustainable development goals both at the level of an individual enterprise and a region, which determines the relevance of the research topic. The article discusses various approaches to the interpretation of the concept of a circular economy. The goals and principles of a circular economy are described, including the analysis of the goals of a circular economy for the micro and meso levels. A study was carried out to identify the relationship between the activities of enterprises adhering to the principles of a circular economy and the development of the regions, from the point of view of the implementation of the principles of this concept. The methodological basis for building a system of indicators for assessing the implementation of the concept of a circular economy and establishing a relationship was the concept of balanced scorecard (BSC). The classic projections "finance", "clients", "internal business processes", "development and training of personnel" for the regional level were adapted to the goals of a circular economy concept, taking into account the peculiarities of the subjects under consideration. For each adapted projection, goals and corresponding assessment indicators were developed, which formed the basis for determining the relationship between the activities of the enterprise and the development of a circular economy in the region. The analysis of the relationship between goals and corresponding systems of indicators for assessing the implementation of the concept of a circular economy for each level (region and enterprise) is carried out. After the formation of the systems of indicators for assessing the implementation of the circular economy concept for the micro and meso levels, their comparative analysis was carried out. It was concluded that there is a relationship between the indicators of these levels and the need to implement the principles of a circular economy starting from the enterprise level. The formed systems of indicators can be used to monitor and control the implementation and consequences of the introduction of the principles of a circular economy.
Uniform arrays of gold nanoelectrodes with tuneable recess depth
Authors: Gordeeva Elena O , Roslyakov Ilya V , Leontiev Alexey P , Klimenko Alexey A , Napolskii Kirill S
Published: August 2021

Nanoelectrode arrays are much in demand in electroanalytical chemistry, electrocatalysis, and bioelectrochemistry. One of the promising approaches for the preparation of such systems is templated electrodeposition. In the present study, porous anodic alumina templates are used to prepare Au nanoelectrode arrays. Multistage electrodeposition is proposed for the formation of recessed electrodes with the ability to tune the distance between the surface of the porous template and the top surface of the nanoelectrodes. A set of complementary techniques, including chronoamperometry, coulometry, and scanning electron microscopy, are used to characterize the nanoelectrode arrays. The number of active nanoelectrodes is experimentally measured. The pathways to further improve the recessed nanoelectrode arrays based on anodic alumina templates are discussed.
PENERAPAN MODEL DISCOVERY LEARNING YANG BERORIENTASI HOTS DALAM PEMBELAJARAN MATERI TEKS DESKRIPSI DI KELAS VII
Authors: Sakila Sakila
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan penerapan model discovery learning yang berorientasi HOTS pada pembelajaran menulis teks deskripsi dalam meningkatkan kemampuan siswa. Adapun rumusan masalah dalam penelitian ini adalah bagaimanakah penerapan model discovery learning yang berorientasi HOTS dalam meningkatkan keterampilan siswa pada materi pembelajaran menulis teks deskripsi. Pentingnya permasalahan ini dibahas karena pembelajaran teks deskripsi dengan menggunakan model pembelajaran sangat penting untuk dipelajari dan teks deskripsi bertujuan untuk memberikan gambaran detail tentang sesuatu atau seseorang. Penelitian ini menggunakan metode deskriptif kualitatif. Hasil penelitian menunjukkan penggunaan model discovery learning yang berorientasi HOTS meningkatkan kemampuan siswa dalam menulis teks deskripsi. Model pembelajaran discovery learning yang berorientasi HOTS dapat dijadikan salah satu alternatif untuk meningkatkan kemampuan siswa dalam pembelajaran menulis teks deskripsi.This study aims to describe the application of HOTS-oriented discovery learning models to learning to write descriptive text in improving students' abilities. The problematic formulation in this research is how the application of discovery learning model that is HOTS oriented in improving students' skills in learning material to write description text. The importance of this problem is discussed because learning the description text using the learning model is very important to learn and the description text aims to provide a detailed picture of something or someone. This study used descriptive qualitative method. The results showed that the use of discovery learning models that were oriented to HOTS improved the ability of students to write description texts. HOTS-oriented discovery learning model can be used as an alternative to improve students' ability in learning to write descriptive text.
THE USE OF INDONESIA TRADITIONAL GAME TO UPGRADE PUPILS SPEAKING SKILLS AND LESSEN PUPILS SPEAKING ANXIETY
Authors: Syahria Nukmatus
Published: August 2021

This article examine the effectiveness of Indonesia traditional game, engklek, to upgrade the pupils speaking skills and to minimize the pupils speaking anxiety. The study found that games have several of disadvantages. One of the game are not appropriate to be applied in the upper level (adult) because some of them consider that games are bothering. Other study claims that games give several kinds of advantages in the teaching and learning activities and it is suitable to be applied for any level of age. The clashing research findings from both studies lead the researcher’s curiosity to investigate the effectiveness of Indonesia traditional game to boost university pupils speaking skills. The designs adopt in this study are experimental design and descriptive design. The results showed that the treatment given to the experimental group (engklek game) is able to give an impact to increase the score of pupils speaking skills that is higher than the control group (presentation technique). The majority of the pupils agree that engklek game is effective to upgrade the pupils speaking fluency, lessen the pupils anxiety, and boost the pupils motivation, cognitive and social skills.Penelitian ini menguji keefektifan permainan tradisional Indonesia, engklek, untuk meningkatkan keterampilan berbicara siswa dan mengurangi kecemasan berbicara siswa. Salah satu penelitian menemukan bahwa permainan memiliki beberapa kekurangan, salah satunya yaitu permainan tidak seharusnya diterapkan di level atas (dewasa) karena beberapa di antaranya menganggap hal tersebut tersebut mengganggu dan merepotkan. Dalam penelitian lain, dinyatakan bahwa permainan menawarkan beberapa macam keunggulan dalam kegiatan belajar mengajar dan cocok untuk diterapkan di segala tingkatan usia. Temuan penelitian yang saling bertabrakan dari kedua studi tersebut mendorong rasa keingintahuan peneliti untuk menyelidiki keefektifan permainan tradisional Indonesia dalam meningkatkan kemampuan berbicara para mahasiswa. Penelitian ini mengadopsi desain eksperimental dan desain deskriptif. Hasil penelitian menunjukkan bahwa perlakuan yang diberikan kepada kelompok eksperimen (engklek) mampu memberikan dampak peningkatan pada skor speaking siswa yang lebih tinggi dibandingkan kelompok kontrol (teknik presentasi). Mayoritas siswa setuju bahwa permainan engklek efektif untuk meningkatkan kefasihan berbicara siswa, mengurangi kecemasan siswa, dan meningkatkan motivasi, keterampilan kognitif, dan sosial siswa.
PENGGUNAAN MEDIA PEMBELAJARAN BAHASA INDONESIA UNTUK ANAK BERKEBUTUHAN KHUSUS DI SEKOLAH MENENGAH PERTAMA LUAR BIASA (SMPLB) NEGERI SEPULAU BANGKA (Using Media in Learning Indonesian Subject for Children with Special Needs at SMPLB in Bangka Regency)
Authors: Harista Eva
Published: August 2021

Penggunaan media dalam  pembelajaran Bahasa Indonesia antara anak yang normal dengan anak berkebutuhan khusus memiliki perbedaan. Tujuan penelitian ini adalah untuk melihat ragam media pembelajaran bahasa Indonesia yang digunakan guru di sekolah menengah pertama luar biasa (SMPLB) negeri se-Pulau Bangka serta kendala yang dihadapi para guru dalam proses pembelajaran bahasa Indonesia. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif. Teknik pengumpulan data melalui tahapan observasi, wawancara, dan dokumentasi. Adapun analisis data dalam penelitian ini, yaitu data collection, data reduction, data display, dan conclusion drawing/verification. Hasil penelitian dapat disimpulkan bahwa media pembelajaran yang digunakan oleh guru dalam mata pelajaran bahasa Indonesia berdasarkan karakteristik ketunaan siswa berkebutuhan khusus, yaitu terdiri dari media pembelajaran audio, visual, maupun audio visual. Kendala dalam proses belajar mengajar di SLB Negeri Sungailiat, Pangkalpinang, dan Koba adalah keterbatasan sarana dan prasarana seperti ruang kelas/pembelajaran, ruang orientasi dan mobilitas, ruang bina wicara, ruang bina persepsi bunyi dan irama, keterbatasan guru, dan keterbatasan media pembelajaran. Using media in Indonesian language learning between normal children and children with special needs has differences. The purpose of this research is to see the variety of Indonesian language learning media used by teachers in The Extraordinary Junior High School (SMPLB) in Bangka Island as well as the obstacles faced by teachers in the indonesian language learning process. This research used descriptive qualitative approach. Data collection techniques were got through the stages of observation, interviews, and documentation. There was data analysis in this research, namely data collection, data reduction and display, conclusion  and verification. From the results of the study, it can be concluded that the learning media used by teachers in Indonesian subjects are based on the disability characteristics of students with special needs; namely consisting of audio, visual, and audio-visual learning media. Constraints in the teaching and learning process at SLB Negeri Sungailiat, Pangkalpinang, and Koba are the limited facilities and infrastructure such as class / learning rooms, orientation and mobility rooms, speech building rooms, sound and rhythm perception building rooms, teacher limitations, and limited learning media.
The Multiple Benefits of Motor Competence Skills in Early Childhood
Authors: Hudson Kesha N. , Willoughby Michael T.
Published: August 2021

Recent findings from the Kids Activity and Learning Study complement North Carolina’s multidimensional approach to promoting school readiness by emphasizing the integrated nature of motor and cognitive development in early childhood. Children whose motor skills improved the most over the course of an academic year also tended to demonstrate the biggest gains in executive function and numeracy skills. Children who participated in adaptive, group-based motor skill activities demonstrated gains in motor competence, executive function, and numeracy skills. Incorporating motor activities into established classroom practices has the potential to facilitate multiple aspects of children’s development and promote school readiness. The brief includes specific recommendations for early childhood educators.
Development study of new topical formulations with erythromycin
Authors:   Faculty of Pharmacy, „Grigore T. Popa“ University of Medicine and Pharmacy, Iasi, OCHIUZ Lacramioara , CRETEANU Andreea ,   Faculty of Pharmacy, „Grigore T. Popa“ University of Medicine and Pharmacy, Iasi, HORTOLOMEI Manuela ,   Ester Farm LTD, Iasi, PEPTU Catalina Anisoara ,   Faculty of Chemical Engineering and Protection of the Environment,  “Gheorghe Asachi“ Technical University, Iasi, STOLERIU Iulian ,   Faculty of Mathematics, „Alexandru Ioan Cuza“ University, Iasi, POPA Marcel ,   The Academy of Romanian Scientists, Bucharest, PEPTU Cristian ,   “Petru Poni“ Institute of Macromolecular Chemistry, Iasi
Published: August 2021

Erythromycin is a macrolide antibiotic prescribed for the topical treatment of acne. Pharmacologically, erythromycin has the disadvantage of being poorly soluble in water. This leads to formulation challenges in semisolid dosage forms. In recent years, many published studies have shown the ability of cyclodextrins to form complexes with drugs. These new complexes are characterized by much improved solubility and permeation compared to the „parent“ molecule. The aim of this study was to synthesize an inclusion complex of erythromycin and lactide-β-cyclodextrin for the formulation of semisolid bases and the development of innovative topical preparations with erythromycin. The erythromycin-lactide-βcyclodextrin complex was characterized by scanning electron microscopy and Fourier-transform infrared spectroscopy. Semisolid formulations were pharmacologically evaluated by in vitro dissolution test and kinetic analysis of drug release by fitting to representative mathematical models. The results obtained showed a prolonged release of erythromycin from erythromycin-lactide-β-cyclodextrin formulations and a higher permeability coefficient of these formulations compared to the erythromycin-based release.
THE SPECTRUM OF RENAL OSTEODYSTROPHY – NOVEL AND OLD PARADIGMS
Authors:   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Bojinca Violeta ,   Sf. Maria Clinical Hospital, Bucharest, Romania, Popescu Daria ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Capusa Cristina ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Dr. Carol Davila Clinical Hospital of Nephrology, Bucharest, Romania
Published: August 2021

“Chronic kidney disease-related mineral and bone disorder” is a newly introduced concept which replaced the former term of “renal osteodystrophy” or “renal bone disease”. It highlights the need for understanding the complex relationships among calcium-phosphate axis, bone metabolism, ectopic calcification and cardiovascular morbidity and mortality in patients with chronic kidney disease. It has the merit to shift the focus from monitoring and treating separate biochemical abnormalities at all costs to the greater aim of improvement survival and reducing major cardiovascular events. However, mainly because of the lack of reliable assessment tools, the bone disorders component is discussed to a much lesser extent even it accounts for major physical disabilities and result in significant impairment of the quality of life. Therefore, the current review aimed to briefly remind the older and newer knowledge in the field of bone changes that occur during the course of chronic kidney disease.