bluuebunny/crossref_metadata_2025 huggingface dataset:
Withania coagulans Dunal.: A Narrative Review of an Anti-diabetic Shrub
of the Desert Biome
Authors: Balkrishna Acharya , Mishra Shalini , Singh Shalini , Rana Maneesha , Arya Vedpriya , Mishra Rajesh , Rajput Satyendra Kumar , Kumar Ashwani
Published: January 2024

Diabetes mellitus is a chronic disease affecting more than 300 million people worldwide.
Even after advances in medicine, we are still away from a permanent solution to this problem. Longterm
use of currently available treatments are associated with adverse effects ranging from cardiovascular
conditions, renal disorders, liver ailments, and weight gain. Subsequently, a significant diabetic
population seeks herbal medicines that are said to control blood sugar levels. Several plants
have been explored in this context; one such plant is Withania coagulans Dunal., which is known for
the hypoglycemic property due to its fruits. Different plant parts and bioactive components like withanolides
exhibited anti-diabetic activity in type 2 diabetes models in vivo and in vitro. However,
clinical studies are limited and more research is warranted. Bioactive composition of W. coagulans
include Withanolide J, F; Coagulin C, E, L; Ajugin E, Withaperuvin C and others. Bioavailability of
Withaferin A from W. coagulans was enhanced by co-administration of Piperine. Herbal quality
control and commercialization aspects are also highlighted. W. coagulans can be employed in managing
type 2 diabetes mellitus after detailed follow-up studies.
β-lactamase and Plasmid-mediated Quinolone Resistance Determinants
Among Proteus spp. Isolates at a Tertiary-care Hospital in Kolkata, India
Authors: Mallick Abhi , Barik Mili , Sarkar Soma , Das Surojit
Published: January 2024

Background:

Emerging antibiotic resistance (ABR) in Proteus spp., especially to third-generation cephalosporins (3GCc), carbapenems, and fluoroquinolones, challenges the treatment outcome and infection prevention. Limited studies pose a knowledge gap between them and ABR.

Methods:

We investigated the in vitro efficacy of therapeutic options and prevalence of β-lac-tamase and plasmid-mediated quinolone resistance (PMQR) traits in 3GC- and/or fluoroquino-lone-nonsusceptible Proteus (P.) spp. (n=27) in Kolkata, India, during 2021–2022. P. mirabilis was commonly isolated (>80%) from superficial and urine samples. The majority of the isolates (48-78%) remained susceptible to piperacillin-tazobactam, meropenem, amikacin, cefoperazone-sulbactam, and cefepime.

Results:

All isolates showed >0.2 multiple-antibiotic resistance index, with >65% being multi-drug and >30% being extensively drug-resistant. blaTEM (n=9), blaNDM (n=9), and qnrA (n=6) were commonly noted with the co-production of β-lactamases and PMQR in ten (37%) isolates. More than 50% of the isolates were devoid of the tested acquired genes.

Conclusion:

The study concludes that superbugs dominate, with limited occurrence of plasmid-borne markers in this geographic location.
Exploring the Role of Cathelicidin Antimicrobial Peptide, Toll-Like
Receptor 4, and HMGB-1 in Bacterial Infection
Authors: Febriza Ami , Idrus Hasta Handayani , Kasim Vivien Novarina
Published: January 2024

Background and Aim:

Lipopolysaccharides (LPS) from Salmonella typhi will attach with Toll-Like Receptor 4 (TLR-4) and trigger an inflammatory response to fight the pathogen. Due to infection, the HMGB1 is produced by immune cells or secreted passively from dead cells. Fur-thermore, the antimicrobial peptide, cathelicidin was secreted to neutralize and eliminate these path-ogens. This study aims to examine the interaction of Cathelicidin antimicrobial peptide (CAMP), TLR-4, and HMGB-1 on inhibiting bacterial growth in Salmonella infection.

Methods:

This study is an experiment that uses a pre-post-test design. Mice balb/c were separated into three groups; group A received levofloxacin for five days, group B received a placebo, and group C was the control. Both groups, A and B, received an injection of S. Typhi strain thy1. Blood samples were taken from three groups on the 4th, 10th, and 30th day to calculate CAMP, TLR-4, and HMGB-1 mRNA gene expression levels. To determine bacterial colony, peritoneal fluid was taken three times on the 4th, 10th, and 30th day to calculate bacterial colony.

Results:

Our finding observed that the expression of mRNA CAMP was inversely related to bacte-rial colony count, which means that higher CAMP mRNA expression was associated with reduced bacterial colony count in groups A and B. The expression of HMGB-1 mRNA was found to be positively correlated with bacterial growth in group A. Meanwhile, TLR-4 mRNA expression did not significantly correlate with bacterial colony count in any groups.

method:

This study is an experiment that uses a pre-post-test design. Mice balb/c were separated into three groups; group A received levofloxacin for five days, group B received a placebo, and group C was the control. Both groups, A and B, received an injection of S. Typhi strain thy1. Blood samples were taken from three groups on the 4th, 10th, and 30th day to calculate CAMP, TLR-4, and HMGB-1 mRNA gene expression levels. To determine bacterial colony, peritoneal fluid was taken three times on the 4th, 10th, and 30th day to calculate bacterial colony.

Conclusions:

CAMP, TLR-4, and HMGB-1 affect bacterial infections. Higher expression CAMP mRNA levels lower colony counts. Meanwhile, decreasing TLR-4 and HMGB-1 mRNA expression were found during the study, due to reducing growth bacteria.

result:

The expression of mRNA CAMP and bacterial colony count correlated negatively. The expression of HMGB-1 mRNA correlated with bacterial growth. Higher CAMP mRNA expression was found to relate to reduced bacterial colony count in groups A and B using linear regression.
Tumor Targeting via siRNA-COG3 to Suppress Tumor Progression in Mice
and Inhibit Cancer Metastasis and Angiogenesis in Ovarian Cancer Cell
Lines
Authors: Ijabi Janat , Ijabi Roghayeh , Roozehdar Parisa , Kaminsky Zachary A. , Moradi-Sardareh Hemen , Tehranian Najmeh , Ahmed Naveed
Published: January 2024

Background:

The COG complex is implicated in the tethering of retrograde intra-Golgi vesicles, which involves vesicular tethering and SNAREs. SNARE complexes mediate the inva-sion and metastasis of cancer cells through MMPs which activate growth factors for ECM frag-ments by binding to integrin receptors. Increasing MMPs is in line with YKL40 since YKL40 is linked to promoting angiogenesis through VEGF and can increase ovarian cancer (OC) resistance to chemotropic and cell migration.

Objective:

The aim of this study is an assessment of siRNA-COG3 on proliferation, invasion, and apoptosis of OC cells. In addition, siRNA-COG3 may prevent the growth of OC cancer in mice with tumors.

Methods:

Primary OC cell lines will be treated with siRNA-COG3 to assay YKL40 and identified angiogenesis by Tube-like structure formation in HOMECs. The Golgi morphology was analyzed using Immunofluorescence microscopy. Furthermore, the effects of siRNA-COG3 on the prolifer-ation and apoptosis of cells were evaluated using MTT and TUNEL assays. Clones of the HOSEpiC OC cell line were subcutaneously implanted in FVB/N mice. Mice were treated after two weeks of injection of cells using siRNA-COG3. Tumor development suppression was detected by D-luciferin. RT-PCR and western blotting analyses were applied to determine COG3, MT1-MMP, SNAP23, and YKL40 expression to investigate the effects of COG3 gene knockdown.

Results:

siRNA-COG3 exhibited a substantial effect in suppressing tumor growth in mice. It dra-matically reduced OC cell proliferation and triggered apoptosis (all p < 0.01). Inhibition of COG3, YKL-40, and MT1-MPP led to suppression of angiogenesis and reduction of microvessel density through SNAP23 in OC cells.

Conclusion:

Overall, by knockdown of the COG3 gene, MT1-MMP and YKL40 were dropped, leading to suppressed angiogenesis along with decreasing migration and proliferation. SiRNA-COG3 may be an ideal agent to consider for clinical trial assessment therapy for OC, especially when an antiangiogenic SNAR-pathway targeting drug.
Multilingual Speaker Recognition using Mel-frequency Cepstral Coefficients and Gaussian Mixture Model
Authors: Rahul Mayur , Jha Sonu Kumar , Prakash Ayushi , Verma Sarvachan , Yadav Vikash
Published: January 2024

Introduction:

People can recognize a speaker with the help of their voice via mobile or digital devices.

Method:

To obtain this congenital human being ability, authentication techniques based on speaker biometrics like automated speaker recognition (ASR) have been proposed. An ASR identifies speakers by speech signals analysis and salient feature extraction from their voices.

Result:

This will become an important part of recent research in the voice biometrics field. This paper proposes multilingual speaker recognition with the help of MFCC as feature extraction and GMM as classification techniques using various available datasets such as TIMIT, librespeech, etc.

Conclusion:

The results achieved from the given datasets enhance the recognition rate of 70.98% with MFCC.
Abutilon indicum: Bioactive Compounds and Diverse Therapeutic
Applications
Authors: Srivastava Shobhit Prakash , Dikshit Swati , Moharana Ankita , Chaturvedi Neha , Sharma Saurabh , Verma Preeti
Published: January 2024

:

A large variety of secondary metabolites are found in medicinal plants, and the majority
are significant in medicine. One of the well-known plant species used to cure a wide range of human
illnesses is Abutilon indicum. The plant Abutilon indicum has a wide range of therapeutic uses, and
its varied parts have been employed to cure a wide range of ailments. Numerous bioactive substances,
such as polyphenols, flavonoids, alkaloids, saponins, tannins, and glycosides are present in
the plant. Potent antioxidant, anti-inflammatory, antibacterial, hepatoprotective, hypoglycaemic, analgesic,
sedative, and diuretic activities have been demonstrated in these compounds. Additionally,
the plant has been shown to have cytoprotective properties and to guard against DNA damage
brought on by oxidative stress. Future research is required to pinpoint the specific bioactive chemicals
responsible for the pharmacological effects of Abutilon indicum and the molecular mechanisms
underlying the plant's therapeutic uses. Overall, Abutilon indicum has demonstrated great therapeutic
potential and deserves further study as a possible source of homeopathic treatments for various illnesses.
The present study covers a summary of the phytochemical and ethnomedicinal applications
of Abutilon Indicum that would further help in exploring the research in natural medicine.
Predictors of Relapse in Women after Substance Use Treatment: A Cross-sectional Study in the West of Iran
Authors: Ghasemi Faezeh , Bashirian Saeid , Fakher Fatemeh Mohammadi , Barati Majid , Khazaei Salman
Published: January 2024

Background:

Many individuals undergo drug addiction treatment relapse after
treatment. Additionally, a few studies have focused on the unique challenges faced by
women in addiction recovery. Therefore, we aimed to identify predictors of relapse among
women who have undergone drug addiction treatment to develop a more effective intervention
program tailored to their needs.

Methods:

The present cross-sectional study evaluated 320 addicted women from Lorestan
province, Iran, in 2020 who had used illegal substances. Convenience sampling was used
to select participants from outpatient addiction treatment centers, triangular clinics, and
rehabilitation centers. Demographic characteristics, drug use patterns, and risk factors for
addiction were recorded. Predictors of relapse were evaluated using a negative binomial
regression model.

Results:

The study included women with a mean age of 34.78±9.31 years who had a
history of drug addiction relapse. Around 43.44% of the women were married and 36.88%
lived with their husbands. Methamphetamine, opium, and heroin were the commonly used
drugs. The study found that women with primary school education had a higher rate of
relapse (IRR: 1.71, p = 0.01) and women with husbands being substance users (IRR: 1.34,
p = 0.014), history of imprisonment (IRR: 1.51, p = 0.002), smoking (IRR: 1.91, p <
0.001), and alcohol consumption (IRR: 1.49, p = 0.005) were also associated with a higher
rate of relapse.

Conclusion:

In conclusion, this study found that women with primary school education,
husbands being substance users, history of imprisonment, smoking, and alcohol consumption
behavior had a higher rate of relapse. By addressing the identified predictors of relapse,
such programs can improve the success rate of addiction treatment and promote
long-term recovery among women. In addition, this study highlights that addiction relapse
is not necessarily caused by a single factor, and several different personal and environmental
factors can influence this issue.
Studies on the Magneto-structural Properties and Initial Permittivity of Chemically Produced Nanoscale Nickel-substituted Zinc Manganese Mixed Ferrites
Authors: Pandhare Amol B. , Mulik Swapnajit V. , Shikare Karishma S. , Sathe Rutuja B. , Patil Sarjerao B. , Patil Kranti. K. , Delekar Sagar D. , Patil Rajendra P.
Published: January 2024

Objective:

The objective of this work was to study in more detail the dielectric
permittivity and dielectric losses at different frequencies. It is well known that
adding ions increases the dielectric constant and increases the dielectric loss as well
as conductivity. Furthermore, the real part of the dielectric constant decreases with
increasing frequency. Dielectrics are used as a capacitor for storing energy and a
transformer for insulating and cooling agents. To enhance the performance of a semiconductor
device, high-permittivity dielectric materials are used. Another aim of this
study was to gain a better understanding of how frequency influences the dielectric
and electrical properties and what are the mathematical forms of these dependencies.
With this aim, magnetic mixed metal oxide systems ZnMn1-xNixFexO4 (x=0.0, 0.25,
0.5, 0.75, and 1.0) have been synthesized in this work using wet chemical approaches.
The prepared mixed-metal oxide nanomaterials have been characterized using analytical
techniques, viz., XRD, FT-IR, SEM, TEM, VSM, TGA/DTA, etc.

Methods:

Nanoparticles of ZnMn1-xNixFexO4 (x = 0.0, 0.25, 0.5, 0.75, and 1.0) have
been synthesized using the lucrative as well as eco-friendly chemical sol-gel technique.
According to the Debye-Scherrer equation, the generated nanoparticles had an
average crystallite size of 34 nm, and the ferrite sample showed a cubic structure.
Two absorption bands at 411-455 and 595 cm-1 in FT-IR spectroscopy have evidenced
the aforementioned structure to exist in the manufactured samples. The magnetic
curves demonstrated that after nickel replacement, the values of coercivity and
saturation magnetization altered. Between 20 Hz and 1 MHz, a dielectric behavior
demonstrated conductivity and dielectric dispersion owing to interfacial polarization,
as well as the interior of grain boundaries.

Results:

In the present case, it has been observed that the dielectric behavior decreased
with increasing Ni concentration in the above-synthesized compositions.
Such change may be due to the increase in resistivity of Zn-Mn ferrite with the substitution
of nickel concentration and it has indicated the dielectric behavior to be directly
proportional to the square root of conductivity.

Conclusion:

Current research has demonstrated that ferrite nanoparticles have
sparked substantial interest due to their high surface-to-volume ratio, distinctive tunable
capabilities, hydrophilic nature, biocompatibility, and exceptional magnetic properties.
The samples' structural, microstructural, magnetic, and electrical characteristics,
have also been examined.
Formulation and Optimization of Solid Lipid Nanoparticle-based
Gel for Dermal Delivery of Linezolid using Taguchi Design
Authors: Chauhan Iti , Singh Lubhan
Published: January 2024

Background:

Linezolid (LNZ) is a synthetic oxazolidinone antibiotic approved
for the treatment of uncomplicated and complicated skin and soft tissue infections caused
by gram-positive bacteria. Typically, LNZ is administered orally or intravenously in most
cases. However, prolonged therapy is associated with various side effects and lifethreatening
complications. Cutaneous application of LNZ will assist in reducing the dose,
hence minimizing the unwanted side/adverse effects associated with oral administration.
Dermal delivery provides an alternative route of administration, facilitating a local and sustained
concentration of the antimicrobial at the site of infection.

Objective:

The current research work aimed to formulate solid lipid nanoparticles (SLNs)
based gel for dermal delivery of LNZ in the management of uncomplicated skin and soft
tissue infections to maximise its benefits and minimise the side effects.

Methods::

SLNs were prepared by high-shear homogenisation and ultrasound method using
Dynasan 114 as solid lipid and Pluronic F-68 as surfactant. The effect of surfactant concentration,
drug-to-lipid ratio, and sonication time was investigated on particle size, zeta
potential, and entrapment efficiency using the Taguchi design. The main effect plot of
means and signal-to-noise ratio were generated to determine the optimized formulation.
The optimized batch was formulated into a gel, and ex-vivo permeation study, in-vitro and
in-vivo antibacterial activity were conducted.

Results:

The optimised process parameters to achieve results were 2% surfactant concentration,
a drug-to-lipid ratio of 1:2, and 360 s of sonication time. The optimized batch was
206.3± 0.17nm in size with a surface charge of -24.4± 4.67mV and entrapment efficiency
of 80.90 ± 0.45%. SLN-based gel demonstrated anomalous transport with an 85.43% in
vitro drug release. The gel showed a 5.03 ± 0.15 cm zone of inhibition while evaluated for
in vitro antibacterial activity against Staphylococcus aureus. Ex-vivo skin permeation studies
demonstrated 20.308% drug permeation and 54.96% cutaneous deposition. In-vivo results
showed a significant reduction in colony-forming units in the group treated with LNZ
SLN-based gel.

Conclusion:

Ex-vivo studies ascertain the presence of the drug at the desired site and improve
therapy. In-vivo results demonstrated the ability of SLN-based gel to significantly
reduce the number of bacteria in the stripped infection model. The utilization of SLN as an
LNZ carrier holds significant promise in dermal delivery.
Effects of Choline Supplementation in Diets on Juvenile Pacu (Piaractus mesopotamicus): Productive Performance, Proximate Composition and Serum Lipid Level
Authors: Godoy Antonio C. , Bittencourt Fabio , Fantini-Hoag Leticia , Honorato Claucia A. , da Silva Deividy M. , Signor Altevir , de O. Seno Leonardo , de Castro Burbarelli Maria F. , Boscolo Wilson R. , Neu Dacley H.
Published: January 2024

Introduction:

Pacu (Piaractus mesopotamicus) is a Brazilian fish species of high
commercial value and has emerged as one of the main species with potential for intensive farming. This study aimed to investigate the impact of choline supplementation on
productive performance, visceral fat, hepatosomatic indices, proximate composition, serum biochemical profile, and liver coloration in juvenile pacu (Piaractus mesopotamicus).

Method:

The 60-day experiment was conducted in the experimental hatchery of the Study
Group of Aquaculture Management - GEMAq of the State University of West Paraná, Brazil.
The completely randomized design consisted of five treatments with four replicates each. A
total of 200 fish, with an average initial weight and length of 4.25 g and 5.97 cm, were distributed among 20 experimental hapas, resulting in a stocking density of 10 fish per experimental unit. Fish fed a choline-deficient diet exhibited the lowest values for final weight,
weight gain, visceral fat, and hepatosomatic index. Conversely, in terms of proximate composition, fish fed choline-deficient diets had the highest moisture content but the lowest crude fat
content. Triglyceride levels in juvenile pacu were significantly higher in groups fed diets
containing choline (400 to 1200 mg kg−1
). We also observed significant differences in the
cyan color of the liver (P < 0.05). Notably, we observed significant differences in the cyan
coloration of the liver (P < 0.05). Other parameters did not exhibit significant changes in response to varying choline levels in the diets.

Result:

Our study demonstrated that choline supplementation in P. mesopotamicus juveniles at
an optimal concentration of 400 mg kg−1 significantly impacted growth, metabolism, productive
performance, proximate composition, biochemical parameters, and liver color.

Conclusion:

These findings offer crucial guidance for aquaculture professionals, enabling them
to enhance growth and health in P. mesopotamicus farming. Further research on choline’s influence on lipid metabolism holds potential for more precise dietary recommendations, ultimately
improving the efficiency and sustainability of aquaculture practices for this species.
A Mobile Health App to Support Home-Based Aerobic Exercise in Neuromuscular Diseases: Usability Study
Authors: Veneman Tim , Koopman Fieke Sophia , Oorschot Sander , Koomen Pien G , Nollet Frans , Voorn Eric L
Published: January 2024

Background

Home-based aerobic exercise in people with neuromuscular diseases (NMDs) has benefits compared to exercise in the hospital or a rehabilitation center because traveling is often cumbersome due to mobility limitations, and societal costs are lower. Barriers to home-based aerobic exercise include reduced possibilities for monitoring and lack of motivation. To overcome these and other barriers, we developed a mobile health app: Keep on training with ReVi (hereafter referred to as ReVi).

Objective

We aimed to determine the usability of the ReVi app.

Methods

Patients followed a 4-month, polarized, home-based aerobic exercise program on a cycle or rowing ergometer, with 2 low-intensity sessions and 1 high-intensity session per week supported by the ReVi app. The app collected training data, including heart rate and ratings of perceived exertion, provided real-time feedback on reaching target intensity zones, and enabled monitoring via an online dashboard. Physiotherapists instructed patients on how to use the ReVi app and supervised them during their training program. Patients and physiotherapists separately evaluated usability with self-developed questionnaires, including 9 questions on a 5-point Likert scale, covering the usability elements efficiency, effectiveness, and satisfaction.

Results

Twenty-nine ambulatory adult patients (n=19 women; mean age 50.4, SD 14.2 years) with 11 different slowly progressive NMDs participated. Both patients and physiotherapists (n=10) reported that the app, in terms of its efficiency, was easy to use and had a rapid learning curve. Sixteen patients (55%) experienced 1 or more technical issue(s) during the course of the exercise program. In the context of effectiveness, 23 patients (81%) indicated that the app motivated them to complete the program and that it helped them to exercise within the target intensity zones. Most patients (n=19, 70%) and physiotherapists (n=6, 60%) were satisfied with the use of the app. The median attendance rate was 88% (IQR 63%-98%), with 76% (IQR 69%-82%) of time spent within the target intensity zones. Four adverse events were reported, 3 of which were resolved without discontinuation of the exercise program.

Conclusions

The usability of the ReVi app was high, despite the technical issues that occurred. Further development of the app to resolve these issues is warranted before broader implementation into clinical practice.
Performance of ChatGPT on the European Society for Medical Oncology (ESMO) Exam: Comparative Analysis (Preprint)
Authors: Filippov Evgenii , Lizogub Olga , Kovalenko Iuliia , Golubykh Konstantin , Khunkhun Ravitej
Published: January 2024

UNSTRUCTURED

In this study, we evaluated the performance of Chat Generative Pre-trained Transformer (ChatGPT) versions 3.5 and 4 in the European Society for Medical Oncology (ESMO) examination, a key test in medical oncology in european countries. We analyzed responses from both AI models to 160 ESMO exam questions, excluding those requiring visual data. ChatGPT-4 demonstrated a notable advancement, achieving 89% overall accuracy and surpassing the 2022 candidates' average scores, with particular strengths in type K and multiple-choice questions. ChatGPT-3.5 also performed well, scoring 77% overall, above the exam's pass/fail limit and 2022 average. Both models, however, showed limitations in questions related to cancer patient management. The results highlight the potential of AI in medical education and evaluation, but also point to the need for further development, especially in patient management areas. These findings suggest the importance of integrating AI into clinical practice to support decision-making and education, while also emphasizing the irreplaceable role of human judgment in healthcare.
A Study on Estimation of Phytochemical, Nutrition and the Antioxidant Activity of Dried Madhuca longifolia Flowers
Authors: A Bibha Mishra , T Usha
Published: January 2024

Abstract: Food derived phytochemicals possess various therapeutic properties to benefit the health of individuals against the illness or diseases caused due to oxidation of free radicals. Mahua (Madhuca longifolia) flowers are one of the most efficient therapeutic agents used through the ancient age mainly among the tribal communities. The present study aimed to analyze the phytochemicals content (both qualitative and quantitative) and antioxidant activity against DPPH (2, 2-diphenyl-1- picrylhydrazyl) of dried mahua flowers using aqueous extract. Phytochemical screening revealed the presence of alkaloids, flavonoids, phenols, terpenoids, cardiac glycosides, coumarins, and steroids whereas anthraquinone was absent in the qualitative analysis. The total phenol and total alkaloids content was found to be 107 and 12.28 mg/g dry extract respectively depicting it as an abundant source. The aqueous extract at the concentration of 8.64 μg/ml showed maximum inhibitory activity (IC50) against DPPH (2, 2-diphenyl-1-picrylhydrazyl). They are also rich in key nutrients such as carbohydrate (48.79 g/100g), fibre (19.16 g/100g) and iron (8.064 mg/100g) of the dry fruit. The reported data reveals mahua flowers to be an excellent source of phytochemical content, nutrition content and antioxidant property emphasizing its therapeutic potential. Thus, further investigation in this regard may contribute to its utilization in the field of nutraceuticals and pharmaco-therapy aiding against various chronic health conditions.
Career Transitions of Football Players
Authors: TUTKUN Erkut , GÖRGÜT İlyas
Published: January 2024

The aim of this study is to find out the career planning of football players who have ended their active sport life and the problems they encounter in line with these plans. In this study qualitative method was used and as a research design, psychological phenomenology approach, which is one of the phenomenological patterns, was preferred. The sample group of the study consists of 13 retired footballers determined with criterion sampling method.Online interviews were conducted with football players using semi-structured interview technique, lasting an average of 30 minutes. After the participants were informed in line with the principles of interview method, the interviews were recorded. Following this, the expressions of the footballers were written down and descriptive and content analysis method was applied on the texts. As a result of the analyses, it was found that the footballers stated that they preferred to continue their career as coach or to work in jobs other than football. Some of the players stated that they experienced financial, emotional and occupational disadvantages due to problems they encountered, that they had negative life satisfaction and they longed to return to their days as a footballer.
Lise Öğrencilerinin Fiziksel Aktivite Düzeyleri ile İyilik Halleri Arasındaki İlişki
Authors: KARTAL Erdem , YARIM İmdat
Published: January 2024

Fiziksel aktivite mekân fark etmeden yapılan, vücut iskelet kas sisteminin enerji harcayarak gerçekleştirdiği, belirli bir program dâhilinde veya hayatın doğal akışı içerisinde her türlü eylemi içerirken;, iyilik hali bireyin sağlığını bütün yönleriyle tanımlar ve ele alır. Diğer bir değişle iyi oluş bireylerin fiziksel gereksinimlerini fark etmesi ve duygusal, zihinsel, ruhsal yönden kendini algılayarak yaşam tarzını bu ihtiyaçlarına göre düzenleyerek kendilerine odaklanma sürecidir. Bu kapsamda mevcut araştırmanın amacı, lise düzeyinde eğitim gören öğrencilerin fiziksel aktivite düzeyleri ile iyi halleri arasındaki ilişkinin incelenmesidir. Araştırmanın evrenini Sakarya ilindeki devlet okullarında öğrenim görmekte olan lise düzeyinde öğrenciler oluşturmaktadır. İlişkisel tarama yöntemi ile tasarlanan araştırmaya, kolayda örnekleme yoluyla seçilen 310 erkek (%56,2) ve 242 kadın (%43,8) olmak üzere toplam 552 (x = 15,39±1,55) öğrenci katılmıştır.Veri toplama aracı olarak, “Fiziksel Aktivite Ölçeği”, “İyi Hal Ölçeği” ve araştırmacılar tarafından geliştirilen “Kişisel Bilgi Formu’’ kullanılmıştır. Veriler tanımlayıcı istatistikler, Pearson korelasyon ve Regresyon analizleri kullanılarak SPSS 26 programında incelenmiştir. Öğrencilerin fiziksel aktivite düzeyleri ile iyilik hali arasında pozitif yönde düşük düzeyde anlamlı bir ilişki olduğu (p
Pemanfaatan Tepung Sukun Sebagai Pengganti Tepung Terigu dalam Pembuatan Farfalle
Authors: Yaji Taka Toshi , Sudiarta I Nyoman
Published: January 2024

Farfalle adalah jenis pasta yang umumnya dikenal sebagai pasta kupu-kupu. Nama ini berasal dari kata italia farfalle (kupu-kupu). Di kota italia Modena, farfalle dikenal sebagai berbagai strichetti. Pasta Farfalle ini terbuat dari campuran telur dan tepung terigu. Dan saat ini permintaan tepung untuk kebutuhan sehari-hari semakin meningkat, maka dari itu diupayakan untuk mengganti tepung terigu dengan tepung sukun dengan alasan tepung sukun memiliki kandungan gizi yang tidak kalah baik dengan tepung terigu. Hasil penelitian menunjukkan kualitas farfalle dengan menggunakan tepung sukun 100% yang diujikan kepada 20 orang panelis dilihat dari segi warna, rasa, tekstur, dan aroma. Penelitian ini menggunakan metode eksperimen, dengan jenis data kualitatif dan kuantitatif. Teknik pengumpulan data yang digunakan adalah kuisioner. Biaya yang diperlukan adalah sebesar Rp. 22,936,- sedangkan biaya perbungkus dengan berat 50 gram sebesar Rp. 5,000,-.
 
Farfalle is a type of pasta commonly known as butterfly paste. The name comes from the Italian word farfalle (butterfly). In the Italian city of Modena, farfalle is known as the strichetti variety. Farfalle pasta is made from a mixture of eggs and wheat flour. And currently the demand for flour for daily needs is increasing, therefore efforts are made to replace wheat flour with breadfruit flour on the grounds that breadfruit flour has a nutritional content that is not inferior to wheat flour. The results showed the quality of farfalle using 100% breadfruit flour which was tested on 20 panelists in terms of color, taste, texture, and aroma. This study uses an experimental method, with qualitative and quantitative data types. The data collection technique used is a questionnaire. The cost required is Rp. 22,936, - while cost per pack weighing 50 grams is Rp. 5,000,-.
Analisis Potensi Daya Tarik Wisata Vihara Dewi Welas Asih sebagai Wisata Religius
Authors: Piter Amelia , Widiastiti A.A Istri Putera , Aprinica Ni Putu Isha
Published: January 2024

Atraksi wisata minat khusus adalah daya tarik wisatawan yang mencari sesuatu yang istimewa dan berbeda untuk menciptakan pengalaman wisata yang berkualitas dan berkesan. Biasanya, pariwisata khusus sesuai dengan kondisi alam, budaya, tradisional dan sejarah dan karena itu memiliki fenomena yang valid dan dapat diamati. Tempat wisata khusus menyediakan kegiatan wisata yang biasanya tidak dilakukan oleh wisatawan biasa. Memakai kata lain dapat dikatakan bahwa wisata minat khusus merupakan kegiatan wisata yang memiliki tendensi keahlian khusus atau ketertarikan khusus, di antaranya berburu, mendaki gunung, wisata gua, wisata agro, wisata ekologi, tempat perbelanjaan, tempat ziarah dan tidak terkecuali kegiatan wisata religi. Melihat dari bangunan atau arsitektur heritage yang dimiliki oleh Vihara Dewi Welas Asih serta ornamen-ornamen yang masih asli dari abad 16 maka keunikan tersebut dapat dijadikan potensi daya tarik wisata. Metode penelitian yang digunakan yaitu SWOT analisis guna mengtahui dan dapat mengukur faktor internal maupun eksternal yang dimiliki oleh Vihara Dewi Welas Asih.
 
Social Media Instagram is one of the media that is very widely used to promote a business or business in order to get high sales. One marketing technique that can be done in an effort to increase the number of purchases is by advertising on Instagram social media. The purpose of this study was to determine how much influence the frequency of ad serving on Instagram @explorenusapenida on purchasing tour packages to Nusa Penida in the new normal era.This study uses quantitative research methods. This research was conducted by processing data on purchasing packages resulting from advertising on Instagram social media in 2020-2021 which were obtained directly at the travel agent @explorenusapenida. The data analysis technique in this research is quantitative descriptive analysis.The results showed that the promotion carried out by the owner of the Instagram account @explorenusapenida regarding the tourist area of the island of Nusa Penida showed a positive influence from the regression results which can be said that the level of purchasing decisions has an effect of 30% while the remaining 70% is influenced by other factors outside of this study.
Evidence of kilometer-wide shallow bulk plastic yielding along the 2021 Maduo, Tibet, surface rupture, and its relation with the dynamic rupture process
Authors: Antoine Solene L , Liu Zhen , Delorme Arthur , Klinger Yann
Published: January 2024

Surface deformation associated with continental earthquake ruptures
includes localized deformation on the faults, as well as deformation in
the surrounding medium though distributed and/or diffuse processes.
However, the connection of the diffuse part of the surface deformation
to the overall rupture process, as well as its underlying physical
mechanisms are not yet well understood. Computing high-resolution
optical image correlations for the 2021/05/21 Mw7.4 Maduo, Tibet,
rupture, we highlight a correlation between the presence of faults and
fractures at the surface, and variations in the across-fault
displacement gradient, fault zone width, and amplitude of surface
displacement. We show that surface slip along primary faults is
systematically associated with gradients greater than 1%, and is
dominant in regions of greater coseismic surface displacement.
Conversely, the diffuse deformation is associated with gradients ≤0.3%,
and is dominant in regions of lesser surface displacement. The
distributed deformation then occurs for intermediate gradients of
0.3-1%, and at the transition between the localized and diffuse
deformation regions. Such patterns of deformation are also described in
laboratory experiments of rock deformation, themself supported by field
observations. Comparing these experiments to our observations, we
demonstrate that the diffuse deformation along the 2021 Maduo rupture
corresponds to kilometer-wide plastic yielding of the bulk medium
occurring in regions where surface rupture is generally missing. Along
the 2021 Maduo rupture, diffuse deformation occurs primarily in the
epicentral region, where the dynamic stresses associated with the
nascent pulse-like rupture could not overcome the shallow fault zone
frictional strength.
The Timescale of Plume-Driven Recratonization: A Complete Record from the Tarim Basin, Northwest China
Authors: Liu Yin , Liu Yiduo , Suppe John , Cao Yingchang , Hao Fang , Wu Kongyou , Cao Zicheng
Published: January 2024

How fast a plume can stitch two cratonic nuclei into a stable one
remains under-investigated. The Tarim continental block in central Asia
is recratonized by a Permian-aged plume and preserves a complete record
before, during, and after the plume-driven recratonization. Here we
conduct area-depth analysis on seismic reflection data from the central
Tarim Basin to date the Phanerozoic deformation. All thrusts and
strike-slip faults investigated underwent an early deformation stage
(Earliest Ordovician-Middle Devonian), a hiatus stage (Late
Devonian-Late Permian), and a newly-discovered deformation stage
throughout the Mesozoic. Both deformation stages within Tarim are driven
by the subduction and accretion surrounding the block. The Mesozoic
finite strains highlight the continuous adjustment as the plume-welded
continental lithosphere heals and strengthens. The Tarim plume-driven
recratonization concludes not immediately, but ~200 Myr
after the plume activity ceased, establishing a characteristic timescale
for such events in Earth’s history.
Frictional properties of natural granite fault gouge under hydrothermal conditions: A case study of strike-slip fault from Anninghe Fault zone, southeastern Tibetan Plateau
Authors: Lei Huiru , Niemeijer André , Zhou Yongsheng , Spiers Christopher James
Published: January 2024

The Anninghe Fault (ANHF) is a large left-lateral strike-slip fault in
southwestern China, and it is one of the major seismogenic fault zones
where several strong earthquakes happened in history with a high level
of seismic potential. To understand the frictional properties of natural
granitic gouges in the principal slip zone, we performed hydrothermal
friction experiments on both saw-cut and ring shear tests.
Velocity-stepping and constant velocity experiments were performed at
temperatures (T) of 25-600 ℃, pore pressure (Pf) of dry, 30 and 100 MPa,
sliding velocities (V) of 0.01-100 μm/s and effective normal stress
(σneff ) of 68, 100 and 200 MPa. The results showed the friction
coefficient (μ) is high (μ=0.64-0.80), when this field remains more or
less constant with T, Pf and V; Conversely, friction was substantially
lower (μ=0.37-0.48), but μ in this field is sensitive to T, Pf and V.
The velocity dependence of friction, (a-b), varies with T, Pf, V, and
fine grain size. At high Pf, velocity-weakening at 100 to 350 ℃, but as
V increases and Pf decreases, the unstable slip at T will increase to
600 ℃. Microstructural observations suggest that the values of μ and
(a-b) are controlled by competition between dilatation by granular flow
and compaction by intergranular pressure solution of fine grains. Our
microphysical-based results provide a possible explanation for the
distribution of earthquakes at different depths in the continental
crust, and earthquake nucleation is up to ~4-24 km along
the ANHF.
Kadar 25-hydroxyvitamin D Pre-operatif pada Lansia dengan Fraktur Tulang Panjang
Authors: Irsan Abror , Mardhia Mardhia , An An
Published: January 2024

Vitamin D merupakan komponen penting pada tubuh. Kadar vitamin D yang cukup dapat terlihat pada densitas mineral tulang, kejadian fraktur, dan fungsi neuromuskular.  Pada lansia, vitamin D berpengaruh terhadap fungsi otot rangka yaitu mengurangi resiko jatuh dan patah tulang. Penelitian mengenai kadar vitamin D preoperatif pada lansia dilakukan secara deskriptif - cross sectional dengan total 35 pasien di Rumah Sakit Anton Soedjarwo, Pontianak pada periode Juli 2022 hingga Desember 2022. Pengukuran konsentrasi serum 25-hydroxyvitamin D dilakukan dengan metode Chemiluminescent Microparticle Immunoassay (CMIA). Pada 35 pasien lansia dengan fraktur tulang panjang didapatkan 23 pasien perempuan dan 12 laki-laki. Kadar 25-hydroxyvitamin D didapatkan kategori defisiensi 23 pasien, insuffisiensi 6 pasien, dan suffisiensi 6 pasien.  Kondisi defisiensi kadar vitamin D paling banyak ditemukan pada kejadian fraktur femur, yaitu 12 pasien. Hasil penelitian menunjukkan mayoritas pasien lansia yang mengalami fraktur tulang panjang mengalami defisiensi vitamin D.
When Numbers Run Out
Authors: Cakici Baki
Published: January 2024

In the early 2000s, authorities in Sweden and Denmark recognised that their personal identification numbers were about to run out but followed different interventions to resolve the same issue. In this paper, I start from these cases to analyse personal identification numbers as methods for knowing and governing populations. I draw on two assertions from the study of methods within STS: Methods are performative, and they produce multiple objects and realities. I demonstrate how such identification numbers enact individuals and populations simultaneously, and I identify a fundamental tension between them: one emphasising the representational potential of the part and another favouring the coherence of the whole. I conclude that issues surrounding personal identification numbers in use across all Nordic countries can be traced back to a fundamental tension in addressing individuals that is impossible to resolve via technical fixes, although those interventions are crucial to keeping the systems operational.
“High performance work system”: challenges and good practices of organizations around the world
Authors: Ksenofontova E. G.
Published: January 2024

The desire to ensure high productivity of each employee in each organization is characteristic of the entire modern world. However, there is no single term used for this, even within an English-speaking (or Russian-speaking) environment, just as there is no common understanding of the factors that can lead to high productivity of each employee. In Russia statistics are collected and programs are being developed that contribute to the growth in the number “High Productivity Jobs” (at the state level). In English-speaking practice, similar approaches are indicated by the abbreviations HPO, HPHRP, HPWP and HPWS. However, similar to the difficulties encountered in the implementation of the concept of “Decent Work” in the world, problems are also experienced by companies trying to apply “high-performance work organization practices”. The published results of the analysis of world publications over the past 30 years show the connection of “high-performance work systems” a) with a variety of personnel management practices (slightly less than in half of the publications); b) with an intermediary factor in the form of staff satisfaction and their sense of subjective well-being (according to some data, most discussed in publications on “high-performance systems”); c) with the effectiveness and productivity of the organization as a whole, and d) with different, not always explicit, attitudes and expectations of employees (allocated to a separate group). Nevertheless, studies periodically show not only successes, but also unpredictable deterioration of indicators that are significant for organizations. The “emotional burnout” of employees and the “imbalance of work and the rest of life” increase attention to the “psychological contract” as ensuring compliance with the complex of mutual expectations of employers and employees. Part of these expectations is related to the currently developing format of hybrid work for some categories of specialists.
Ways to implement higher education strategies as a factor in the formation of student’s professional orientations
Authors: Sushko V. A.
Published: January 2024

In the realities of modern Russian society, the question arises of the relevance of a particular profession, a set of knowledge, skills, which is given in educational institutions of higher education, or as it is commonly called now, a set of competencies or competency maps of a future employee. Therefore, the agenda raises the question of how the current education system is currently ready to implement this practice. Or the level of professional development and competence is now more dependent on the personal perceived quality of life of the individual, his cultural capital, and all the symbolic accumulated capital is secondary. Here the question arises of the public recognition of this or that profession, this or that institution of education.

The article discusses approaches to understanding the profession and professional choice in domestic and foreign scientific thought. The key issues of the study of professional strategies and professional choice are presented in a historical retrospective.

As an empirical basis for the study of this article, students of leading educational institutions of higher education, who have been assigned a special status through the establishment of a specific legal status and educational activity, will be considered — the Federal state budgetary educational institution of higher education “Moscow State University named after M.V. Lomonosov” and the Federal state budgetary educational institution of higher education “St. Petersburg State University”. Based on the empirical data of a sociological study conducted in February 2023, the article analyzes the strategies of universities in terms of the production of knowledge (through the exchange of scientific and teaching staff, scientific events, additional training programs) for the professional self-determination of a student (through his desire to work in this profession and desire to continue their education in this profession).
Social well-being of Russian girls in the conditions of a special military operation
Authors: Smirnov  V. A. , Pogodina Yu. A.
Published: January 2024

In the article, based on the data of an empirical sociological study conducted by the authors in February 2023, certain aspects of the social well-being of Russian girls in the conditions of a special military operation are analyzed.

The study was conducted in 10 subjects of the Central Federal District of the Russian Federation, as well as on the territory of the Republic of Crimea by online questionnaire. The study sample is quota-based, stratified by gender. The sample size is 960 people, aged 18 to 29 years. The volume of the subsample of young women is 510 people.

The article examines the emotional well-being of girls, their stress level, analyzes the impact on them of the geopolitical situation in which Russia is located. The authors draw conclusions about the impact of a special military operation on the professional activities of girls, as well as on their relationships with friends and family. The article substantiates the conclusion about the polarization of young Russians depending on the degree of impact of the military situation on them.
Evaluation of Marginal Adaptation of Metal Ceramic Crown with Different Luting Cement
Authors: M. Al-Shakir Nadia , Abdul-Wahab Sabah , N. Al-Yousifany Neam
Published: January 2024

The study aims to evaluate and compare the microleakage of three different luting materials. The materials compared are Zinc phosphate cement, Variolink II Refill and Glass ionomer resin cement. Eighteen recently extracted caries-free wisdom teeth were used . The teeth were cleaned then stored in distilled water until use. The molars were assigned randomly into three groups of 6 teeth of each . The metal ceramic crowns were constructed by means of an indirect laboratory technique. In group A, the crowns were cemented with a traditional Zinc Phosphate. In group B, the tooth preparations were sealed with Variolink II Refill. In group C, the tooth preparations were sealed with glass ionomer resin cement prior to cementation with the crowns. The results showed higher value of microleakage for Zinc phosphate cement. While the least value was for the Variolink II . The value for Glass ionomer resin cement was low. Statistically analysis revealed difference between the Zinc phosphate cement ,Variolink II and Glass ionomer resin cement in microleakage. There was no significant difference in microleakage between Variolink II and Glass ionomer resin cement. This may indicated that the degree of microleakage may influenced by the type of the luting system used.