bluuebunny/crossref_metadata_2025 huggingface dataset:
Aerodynamic Differences between New and Used Soccer Balls
Authors: Hong Sungchan , Asai Takeshi
Published: August 2021

The surface structure of soccer balls, such as the number and shapes of the ball panels, has recently changed, and research on the aerodynamics and flight trajectories of new soccer balls is actively proceeding. However, these studies are focused on new soccer balls, whereas the used soccer balls were never studied. In this study, the aerodynamic characteristics of soccer balls kicked 1000 times by a robot were investigated through wind tunnel tests. The results were compared with those obtained using new soccer balls. Regarding the aerodynamic characteristics of the soccer balls, it was found that the critical Reynold number, Recrit, changes with usage. This is related to the transition from laminar to turbulent flow of airflow around the ball. The comparison of the drag coefficients of the balls at Recrit showed that the drag coefficients of the new and used Telstar18 balls were 0.15 (Re = 2.5 × 105) and 0.14 (Re = 2.2 × 105), respectively; those of the new and used Merlin were 0.13 (Re = 2.8 × 105) and 0.13 (Re = 2.2 × 105), respectively; and finally, those of the new and used Derbystar were 0.14 (Re = 2.1 × 105) and 0.14 (Re = 2.1 × 105), respectively. The surface conditions of a soccer ball, such as the surface roughness and surface damages, are essential factors to determine the aerodynamics of the soccer balls.
Towards a Real-Time Description of the Ionosphere: A Comparison between International Reference Ionosphere (IRI) and IRI Real-Time Assimilative Mapping (IRTAM) Models
Authors: Pignalberi Alessio , Pietrella Marco , Pezzopane Michael
Published: August 2021

This paper focuses on a detailed comparison, based on the F2-layer peak characteristics foF2 and hmF2, between the International Reference Ionosphere (IRI), which is a climatological empirical model of the terrestrial ionosphere, and the IRI Real-Time Assimilative Mapping (IRTAM) procedure, which is a real-time version of IRI based on data assimilation from a global network of ionosondes. To perform such a comparison, two different kinds of datasets have been considered: (1) foF2 and hmF2 as recorded by 40 ground-based ionosondes spread all over the world from 2000 to 2019; (2) foF2 and hmF2 from space-based COSMIC/FORMOSAT-3 radio occultation measurements recorded from 2006 to 2018. The aim of the paper is to understand whether and how much IRTAM improves IRI foF2 and hmF2 outputs for different locations and under different diurnal, seasonal, solar and magnetic activity conditions. The main outcomes of the study are: (1) when ionosonde observations are considered for validation, IRTAM significantly improves the IRI foF2 modeling both in accuracy and precision, while a slight improvement in the IRI hmF2 modeling is observed for specific locations and conditions; (2) when COSMIC observations are considered for validation, no noticeable improvement is observed from the IRTAM side for both foF2 and hmF2. Indeed, IRTAM can improve the IRI foF2 description only nearby the assimilated ionosonde locations, while the IRI hmF2 description is always more accurate and precise than IRTAM one.
New Species of Talaromyces (Fungi) Isolated from Soil in Southwestern China
Authors: Zhang Zhi-Kang , Wang Xin-Cun , Zhuang Wen-Ying , Cheng Xian-Hao , Zhao Peng
Published: August 2021

Southwestern China belongs among the global biodiversity hotspots and the Daba Mountains are recognized as one of the priority conservation areas. During the exploration of fungal biodiversity from soil samples collected from Mount Daba, two species of Talaromyces were discovered as new to science based on phylogenetic analyses and morphological comparisons. Talaromyces chongqingensis sp. nov. is a sister taxon of T. minioluteus and T. minnesotensis in the section Trachyspermi; and T. wushanicus sp. nov., affiliated to the section Talaromyces, is closely related to T. cnidii and T. siamensis. The new species differ from their sisters in DNA sequences, growth rates, and morphological characteristics. Descriptions and illustrations of them are provided in detail.
Triterpenoid–PEG Ribbons Targeting Selectivity in Pharmacological Effects
Authors: Özdemir Zulal , Bildziukevich Uladzimir , Čapková Martina , Lovecká Petra , Rárová Lucie , Šaman David , Zgarbová Michala , Lapuníková Barbora , Weber Jan , Kazakova Oxana , Wimmer Zdeněk
Published: August 2021

(1) Background: To compare the effect of selected triterpenoids with their structurally resembling derivatives, designing of the molecular ribbons was targeted to develop compounds with selectivity in their pharmacological effects. (2) Methods: In the synthetic procedures, Huisgen 1,3-dipolar cycloaddition was applied as a key synthetic step for introducing a 1,2,3-triazole ring as a part of a junction unit in the molecular ribbons. (3) Results: The antimicrobial activity, antiviral activity, and cytotoxicity of the prepared compounds were studied. Most of the molecular ribbons showed antimicrobial activity, especially on Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis, with a 50–90% inhibition effect (c = 25 µg·mL−1). No target compound was effective against HSV-1, but 8a displayed activity against HIV-1 (EC50 = 50.6 ± 7.8 µM). Cytotoxicity was tested on several cancer cell lines, and 6d showed cytotoxicity in the malignant melanoma cancer cell line (G-361; IC50 = 20.0 ± 0.6 µM). Physicochemical characteristics of the prepared compounds were investigated, namely a formation of supramolecular gels and a self-assembly potential in general, with positive results achieved with several target compounds. (4) Conclusions: Several compounds of a series of triterpenoid molecular ribbons showed better pharmacological profiles than the parent compounds and displayed certain selectivity in their effects.
How to Improve Prognostication in Acute Myeloid Leukemia with CBFB-MYH11 Fusion Transcript: Focus on the Role of Molecular Measurable Residual Disease (MRD) Monitoring
Authors: Talami Annalisa , Bettelli Francesca , Pioli Valeria , Giusti Davide , Gilioli Andrea , Colasante Corrado , Galassi Laura , Giubbolini Rachele , Catellani Hillary , Donatelli Francesca , Maffei Rossana , Martinelli Silvia , Barozzi Patrizia , Potenza Leonardo , Marasca Roberto , Trenti Tommaso , Tagliafico Enrico , Comoli Patrizia , Luppi Mario , Forghieri Fabio
Published: August 2021

Acute myeloid leukemia (AML) carrying inv(16)/t(16;16), resulting in fusion transcript CBFB-MYH11, belongs to the favorable-risk category. However, even if most patients obtain morphological complete remission after induction, approximately 30% of cases eventually relapse. While well-established clinical features and concomitant cytogenetic/molecular lesions have been recognized to be relevant to predict prognosis at disease onset, the independent prognostic impact of measurable residual disease (MRD) monitoring by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR), mainly in predicting relapse, actually supersedes other prognostic factors. Although the ELN Working Party recently indicated that patients affected with CBFB-MYH11 AML should have MRD assessment at informative clinical timepoints, at least after two cycles of intensive chemotherapy and after the end of treatment, several controversies could be raised, especially on the frequency of subsequent serial monitoring, the most significant MRD thresholds (most commonly 0.1%) and on the best source to be analyzed, namely, bone marrow or peripheral blood samples. Moreover, persisting low-level MRD positivity at the end of treatment is relatively common and not predictive of relapse, provided that transcript levels remain stably below specific thresholds. Rising MRD levels suggestive of molecular relapse/progression should thus be confirmed in subsequent samples. Further prospective studies would be required to optimize post-remission monitoring and to define effective MRD-based therapeutic strategies.
Focusing of Particles in a Microchannel with Laser Engraved Groove Arrays
Authors: Zhang Tianlong , Shen Yigang , Kiya Ryota , Anggraini Dian , Tang Tao , Uno Hanaka , Okano Kazunori , Tanaka Yo , Hosokawa Yoichiroh , Li Ming , Yalikun Yaxiaer
Published: August 2021

Continuous microfluidic focusing of particles, both synthetic and biological, is significant for a wide range of applications in industry, biology and biomedicine. In this study, we demonstrate the focusing of particles in a microchannel embedded with glass grooves engraved by femtosecond pulse (fs) laser. Results showed that the laser-engraved microstructures were capable of directing polystyrene particles and mouse myoblast cells (C2C12) towards the center of the microchannel at low Reynolds numbers (Re < 1). Numerical simulation revealed that localized side-to-center secondary flows induced by grooves at the channel bottom play an essential role in particle lateral displacement. Additionally, the focusing performance proved to be dependent on the angle of grooves and the middle open space between the grooves based on both experiments and simulation. Particle sedimentation rate was found to critically influence the focusing of particles of different sizes. Taking advantage of the size-dependent particle lateral displacement, selective focusing of micrometer particles was demonstrated. This study systematically investigated continuous particle focusing in a groove-embedded microchannel. We expect that this device will be used for further applications, such as cell sensing and nanoparticle separation in biological and biomedical areas.
Association between Visceral Fat and Brain Structural Changes or Cognitive Function
Authors: Ozato Naoki , Saitou Shinnichiro , Yamaguchi Tohru , Katashima Mitsuhiro , Misawa Mina , Jung Songee , Mori Kenta , Kawada Hiromitsu , Katsuragi Yoshihisa , Mikami Tatsuya , Nakaji Shigeyuki
Published: August 2021

Visceral fat accumulation is an independent risk factor for cardiovascular disease and mortality. Visceral fat is a causal risk factor for hypertension and type 2 diabetes, which was reported as one of the risk factors for dementia. Visceral fat areas (VFA) might be clinically important to prevent dementia; however, the association between VFA and cognitive function in the elderly remains unknown. We aimed to evaluate the association between brain structural abnormalities using magnetic resonance imaging (MRI) and VFA, and the association between cognitive function and VFA, in the elderly. A total of 2364 healthy individuals were enrolled, and we excluded those diagnosed with dementia. Participants were divided into a high-VFA and a low-VFA group based on median VFA. The high-VFA group had significantly lower cognitive function than the low-VFA group (p = 0.025), after adjustment for related factors using a linear regression model. Regarding brain structure in MRI, VFA remained significantly associated with white matter lesions (odds ratio (OR), 1.90; 95% confidence interval (1.33–2.70); adjusted p < 0.001) and perivascular space (OR, 1.28; 95% confidence interval (1.02–1.61); adjusted p = 0.033). Further follow-up studies are needed, but reducing visceral fat might be important, not only to prevent cardiovascular disease but also to prevent dementia.
A Biopsychosocial Approach to Grief, Depression, and the Role of Emotional Regulation
Authors: Peña-Vargas Cristina , Armaiz-Peña Guillermo , Castro-Figueroa Eida
Published: August 2021

According to the field of affective neuroscience, grief has been identified as one of the seven primary emotions necessary for human survival. However, maladaptive grief could cause significant impairment in an individual’s life, leading to psychopathologies such as major depressive disorder. Research on grief has shifted to a biopsychosocial approach, leaving behind outdated models—such as the Kübler-Ross theory—that have shown poor consistency. The field of psychoneuroimmunology has identified adverse life events such as social loss as being associated with major depressive disorder, and inflammatory processes in chronic health conditions. Likewise, scientists in the field of affective neuroscience have theorized that prolonged and sustained activation of the grief neurological pathway can cause a cascade of neurotransmitters that inhibits the reward-seeking system, causing symptoms of depression. The objective of this review is to highlight findings on the grief process using a biopsychosocial approach to explore grief’s impact on psychopathophysiology.
Biomarkers and Lung Cancer Early Detection: State of the Art
Authors: Dama Elisa , Colangelo Tommaso , Fina Emanuela , Cremonesi Marco , Kallikourdis Marinos , Veronesi Giulia , Bianchi Fabrizio
Published: August 2021

Lung cancer burden is increasing, with 2 million deaths/year worldwide. Current limitations in early detection impede lung cancer diagnosis when the disease is still localized and thus more curable by surgery or multimodality treatment. Liquid biopsy is emerging as an important tool for lung cancer early detection and for monitoring therapy response. Here, we reviewed recent advances in liquid biopsy for early diagnosis of lung cancer. We summarized DNA- or RNA-based biomarkers, proteins, autoantibodies circulating in the blood, as well as circulating tumor cells (CTCs), and compared the most promising studies in terms of biomarkers prediction performance. While we observed an overall good performance for the proposed biomarkers, we noticed some critical aspects which may complicate the successful translation of these biomarkers into the clinical setting. We, therefore, proposed a roadmap for successful development of lung cancer biomarkers during the discovery, prioritization, and clinical validation phase. The integration of innovative minimally invasive biomarkers in screening programs is highly demanded to augment lung cancer early detection.
Vitreoretinal Lymphoma
Authors: Sobolewska Bianka , Chee Soon-Phaik , Zaguia Fatma , Goldstein Debra Anne , Smith Justine R. , Fend Falko , Mochizuki Manabu , Zierhut Manfred
Published: August 2021

Vitreoretinal lymphoma (VRL) is a rare variant of primary central nervous system lymphoma (PCNSL), mostly of diffuse large B cell lymphoma, which affects the retina and/or the vitreous with or without optic nerve involvement. The disease course is aggressive. Up to 90% of the patients develop central nervous system lymphoma within one year. The diagnosis of VRL is challenging due to nonspecific chronic and relapsing uveitis and is made by anterior chamber tab or vitreous aspirate biopsy. There is no established treatment protocol for VRL patients with bilateral involvement without CNS involvement. There are suggestions to use only intravitreal chemotherapy with methotrexate and/or rituximab. Alternatively, systemic high-dose MTX treatment or external beam radiotherapy is used. Further studies are needed to prove and confirm the prophylactic systemic therapy in preventing CNS involvement in limited VRL.
Transcriptomic Profiling Reveals Novel Candidate Genes and Signalling Programs in Breast Cancer Quiescence and Dormancy
Authors: Quayle Lewis A. , Spicer Amy , Ottewell Penelope D. , Holen Ingunn
Published: August 2021

Metastatic recurrence, the major cause of breast cancer mortality, is driven by reactivation of dormant disseminated tumour cells that are defined by mitotic quiescence and chemoresistance. The molecular mechanisms underpinning mitotic quiescence in cancer are poorly understood, severely limiting the development of novel therapies for removal of residual, metastasis-initiating tumour cells. Here, we present a molecular portrait of the quiescent breast cancer cell transcriptome across the four main breast cancer sub-types (luminal, HER2-enriched, basal-like and claudin-low) and identify a novel quiescence-associated 22-gene signature using an established lipophilic-dye (Vybrant® DiD) retention model and whole-transcriptomic profiling (mRNA-Seq). Using functional association network analysis, we elucidate the molecular interactors of these signature genes. We then go on to demonstrate that our novel 22-gene signature strongly correlates with low tumoural proliferative activity, and with dormant disease and late metastatic recurrence (≥5 years after primary tumour diagnosis) in metastatic breast cancer in multiple clinical cohorts. These genes may govern the formation and persistence of disseminated tumour cell populations responsible for breast cancer recurrence, and therefore represent prospective novel candidates to inform future development of therapeutic strategies to target disseminated tumour cells in breast cancer, eliminate minimal residual disease and prevent metastatic recurrence.
The Proper Administration Sequence of Radiotherapy and Anti-Vascular Agent—DMXAA Is Essential to Inhibit the Growth of Melanoma Tumors
Authors: Drzyzga Alina , Cichoń Tomasz , Czapla Justyna , Jarosz-Biej Magdalena , Pilny Ewelina , Matuszczak Sybilla , Wojcieszek Piotr , Urbaś Zbigniew , Smolarczyk Ryszard
Published: August 2021

Vascular disrupting agents (VDAs), such as DMXAA, effectively destroy tumor blood vessels and cause the formation of large areas of necrosis in the central parts of the tumors. However, the use of VDAs is associated with hypoxia activation and residues of rim cells on the edge of the tumor that are responsible for tumor regrowth. The aim of the study was to combine DMXAA with radiotherapy (brachytherapy) and find the appropriate administration sequence to obtain the maximum synergistic therapeutic effect. We show that the combination in which tumors were irradiated prior to VDAs administration is more effective in murine melanoma growth inhibition than in either of the agents individually or in reverse combination. For the first time, the significance of immune cells’ activation in such a combination is demonstrated. The inhibition of tumor growth is linked to the reduction of tumor blood vessels, the increased infiltration of CD8+ cytotoxic T lymphocytes and NK cells and the polarization of macrophages to the cytotoxic M1 phenotype. The reverse combination of therapeutic agents showed no therapeutic effect and even abolished the effect of DMXAA. The combination of brachytherapy and vascular disrupting agent effectively inhibits the growth of melanoma tumors but requires careful planning of the sequence of administration of the agents.
Early Alcohol Use Initiation, Obesity, Not Breastfeeding, and Residence in a Rural Area as Risk Factors for Breast Cancer: A Case-Control Study
Authors: Dydjow-Bendek Dorota Anna , Zagożdżon Paweł
Published: August 2021

The aim of this study was to determine the risk factors for breast cancer in the Polish population. In total, 201 Polish women newly diagnosed with breast cancer and 201 one-to-one age-matched healthy controls participated in this case-control study. Data on sociodemographic characteristics, reproductive and menstrual history, medical history, lifestyle factors, and anthropometric measurements were collected by the interviewers. Odds ratios and 95% confidence intervals were obtained using multivariate unconditional logistic regression models controlling for potential confounders. Significant relationships were observed between BMI, alcohol use initiation, breastfeeding, education, and place of residence. Obese women had a higher risk of breast cancer than women with a BMI < 30 (OR = 1.9; 95% CI: 1.16 to 3.04). Early alcohol use initiation (≤15 years) was associated with an almost two-fold higher risk of breast cancer (OR = 1.98, 95% CI: 1.06 to 3.69). Breastfeeding for less than 3 months (OR = 2.3, 95% CI: 1.52 to 3.5), receiving a basic and vocational education (OR = 2.5, 95% CI: 1.49 to 4.19), and living in a rural area (OR = 1.7, 95% CI: 1.05 to 2.9) increased the risk of breast cancer. Prevention activities for breast cancer are already needed in adolescents and young women. A much greater emphasis should also be placed on breast cancer prevention campaigns in rural areas in Poland.
The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis
Authors: Kenny Hilary A. , Hart Peter C. , Kordylewicz Kasjusz , Lal Madhu , Shen Min , Kara Betul , Chen Yen-Ju , Grassl Niklas , Alharbi Yousef , Pattnaik Bikash R. , Watters Karen M. , Patankar Manish S. , Ferrer Marc , Lengyel Ernst
Published: August 2021

The high mortality of OvCa is caused by the wide dissemination of cancer within the abdominal cavity. OvCa cells metastasize to the peritoneum, which is covered by mesothelial cells, and invade into the underlying stroma, composed of extracellular matrices (ECM) and stromal cells. In a study using a three-dimensional quantitative high-throughput screening platform (3D-qHTS), we found that β-escin, a component of horse chestnut seed extract, inhibited OvCa adhesion/invasion. Here, we determine whether β-escin and structurally similar compounds have a therapeutic potential against OvCa metastasis. Different sources of β-escin and horse chestnut seed extract inhibited OvCa cell adhesion/invasion, both in vitro and in vivo. From a collection of 160 structurally similar compounds to β-escin, we found that cardiac glycosides inhibited OvCa cell adhesion/invasion and proliferation in vitro, and inhibited adhesion/invasion and metastasis in vivo. Mechanistically, β-escin and the cardiac glycosides inhibited ECM production in mesothelial cells and fibroblasts. The oral administration of β-escin inhibited metastasis in both OvCa prevention and intervention mouse models. Specifically, β-escin inhibited ECM production in the omental tumors. Additionally, the production of HIF1α-targeted proteins, lactate dehydrogenase A, and hexokinase 2 in omental tumors was blocked by β-escin. This study reveals that the natural compound β-escin has a therapeutic potential because of its ability to prevent OvCa dissemination by targeting both cancer and stromal cells in the OvCa tumor microenvironment.
Simultaneous Galvanic Generation of Fe2+ Catalyst and Spontaneous Energy Release in the Galvano-Fenton Technique: A Numerical Investigation of Phenol’s Oxidation and Energy Production and Saving
Authors: Kerboua Kaouther , Hamdaoui Oualid , Haddour Naoufel , Alghyamah Abdulaziz
Published: August 2021

The present paper investigates the potential of the Galvano-Fenton process as an advanced technique in terms of the simultaneous oxidation of a model pollutant, phenol, and the energy release and saving as compared to conventional electrochemical techniques, namely, Fenton, Fenton-like, and Electro-Fenton. A numerical model describing the electrochemical, electrolytic, and phenol’s mineralization reactions is presented. Simulations are conducted to predict the kinetics of ferrous and ferric ions, radicals’ formation, and phenol degradation along with released power. Parametric analysis and comparisons are also performed between the basic configuration of the Galvano-Fenton process and its upgraded version integrating a pre-immersion stage of the electrodes in the electrolyte equivalent to 25% of the total experiment’s duration. The ratio of the initial concentration of H2O2 to the concentration of the released/added Fe2+ catalyst is varied from 10 to 30. The effect of phenol concentration is inspected over the range of 0.188 to 10 mg/L as well. Compared to conventional Fenton-based techniques, the Galvano-Fenton process demonstrated a higher performance by reaching 1.34% of degradation efficiency per released J. This is associated with the generation of hydroxyl radicals of 0.047 nM/released J with initial concentrations of hydrogen peroxide and phenol of 0.187 mM and 2 µM, respectively. Moreover, the integration of the pre-immersion stage allowed the overcoming the barrier of the null degradation rate at the initial instant.
Investigation into Effect of Natural Shellac on the Bonding Strength of Magnesium Substituted Hydroxyapatite Coatings Developed on Ti6Al4V Substrates
Authors: Aravindakshan Ritwik , Saju Kaiprappady Kunchu , Aruvathottil Rajan Reghuraj
Published: August 2021

The bioactive and biocompatible properties of hydroxyapatite (HA) promote the osseointegration process. To enhance other bio-functions of HA such as improving the antibacterial property of the implant, increasing the rate of cell proliferation, or improving tissue generation capability, HA is substituted with many elements such as Zn, Cl, Ba, Fe, Cu, Ag, Sr, F, Na, etc. This study reports development of Magnesium substituted HA (Mg-HA) coatings on Ti6Al4V substrates using the dip coating technique. To improve the adhesion and stability of the coating, an intermediate layer of shellac was applied between the coating and Ti6Al4V substrate. The dip coating process parameters were optimized using the Taguchi technique and it was found that dipping time of 35 s and 13% w/w of shellac concentration provided the maximum bonding strength of 12.5 MPa. The biocompatibility, dissolution, and corrosion study of the developed coating using the optimal parameters obtained were carried out in this study. An improvement in cell growth and cell proliferation was observed in the extract medium prepared from coated substrates. Release of Ca, P and Mg ions from the surface of the coated substrate into the simulated body fluid (SBF) was found to be almost constant which shows the stability of the thin film coating formed. The Mg-HA coated substrate also exhibited better corrosion resistance than the uncoated substrate.
Design of Novel Photocatalytic Films for the Protection of Architectural Surfaces via the Incorporation of Green Photocatalysts
Authors: Stefanakis Dimitrios , Krasoudaki Themis , Kaditis Anastasios-Ioannis , Bakolas Asterios , Maravelaki Pagona-Noni
Published: August 2021

In conservation science the demand of multifunctional green materials displaying water repellency, consolidation, resistance to organic pollutants and pigments is constantly increasing. This research developed a green nanocomposite exhibiting photocatalytic, hydrophobic, consolidation and self-cleaning properties. This was achieved by synthesizing a TiO2 photocatalyst enriched with carbon dots (C-dots) and successfully incorporated into a tetraethoxysilane nanocomposite modified with nano-calcium oxalate and polydimethylsiloxane. The TiO2/C-dots that were prepared with a simple, low temperature, cost-effective and large-scale procedure were assessed via analytical and spectroscopic techniques and were resulted in anatase structure ranging in size from 10 to 40 nm. Photooxidation measurements displayed that TiO2/C-dots nanoparticles could photodegrade completely Methyl Orange (MO) under UV and visible irradiation after 120 min. The photocatalytic performance of the nanocomposite with TiO2/C-dots resulted promising under UV after longer irradiation time. The degradation of MO was faster on bulk xerogels containing the TiO2/C-dots than the corresponding ones with TiO2. The treatment of concrete, limestone and lime mortars with the nanocomposite proved to be compatible with the substrates in terms of aesthetical aspects. This study demonstrates encouraging potential for large-scale production of a multifunctional protective composite that offers hydrophobicity, self-cleaning properties and consolidation to architectural surfaces.
The Oscillatory Spinning Drop Technique. An Innovative Method to Measure Dilational Interfacial Rheological Properties of Brine-Crude Oil Systems in the Presence of Asphaltenes
Authors: Marquez Ronald , Bullon Johnny , Forgiarini Ana , Salager Jean-Louis
Published: August 2021

The oscillatory spinning drop method has been proven recently to be an accurate technique to measure dilational interfacial rheological properties. It is the only available equipment for measuring dilational moduli in low interfacial tension systems, as it is the case in applications dealing with surfactant-oil-water three-phase behavior like enhanced oil recovery, crude oil dehydration, or extreme microemulsion solubilization. Different systems can be studied, bubble-in-liquid, oil-in-water, microemulsion-in-water, oil-in-microemulsion, and systems with the presence of complex natural surfactants like asphaltene aggregates or particles. The technique allows studying the characteristics and properties of water/oil interfaces, particularly when the oil contains asphaltenes and when surfactants are present. In this work, we present a review of the measurements of crude oil-brine interfaces with the oscillating spinning drop technique. The review is divided into four sections. First, an introduction on the oscillating spinning drop technique, fundamental and applied concepts are presented. The three sections that follow are divided according to the complexity of the systems measured with the oscillating spinning drop, starting with simple surfactant-oil-water systems. Then the complexity increases, presenting interfacial rheology properties of crude oil-brine systems, and finally, more complex surfactant-crude oil-brine systems are reviewed. We have found that using the oscillating spinning drop method to measure interfacial rheology properties can help make precise measurements in a reasonable amount of time. This is of significance when systems with long equilibration times, e.g., asphaltene or high molecular weight surfactant-containing systems are measured, or with systems formulated with a demulsifier which is generally associated with low interfacial tension.
Pyrolysis Preparation Process of CeO2 with the Addition of Citric Acid: A Fundamental Study
Authors: Lv Chao , Sun Ming-He , Yin Hong-Xin , Wang Zhen-Feng , Xia Tian-Yuan
Published: August 2021

CeO2 is an important energy storage material that can be used in solid fuel cells. Adding citric acid can improve the particle distribution of the pyrolytic preparation of CeO2 inside the reactor. Through Fluent, this paper investigated the pyrolysis preparation of CeO2 with the addition of citric acid by adopting the Eulerian multiphase flow model, component transportation model, and standard k-ε turbulence model. The experimental and simulation results suggest that the addition of citric acid can alter the pressure, temperature, and component distributions inside the reactor. When the mass fraction of O2 is 0.3, the concentration distribution effect of the CeO2 component is optimal and its conversation rate is the highest. When the mass fraction of citric acid is 0.04, the concentration distribution effect of the CeO2 component is the best, as witnessed by the high CeO2 concentration at the exit. It was found that an O2 content of 30 wt % and citric acid content of 4 wt % were optimal operating conditions for this technology.
Topological Defect-Guided Regular Stacking of Focal Conic Domains in Hybrid-Aligned Smectic Liquid Crystal Shells
Authors: Noh JungHyun , Lagerwall Jan P. F.
Published: August 2021

We study liquid crystal (LC) shells in hybrid configuration (director tangential to the inside but normal to the outside) as they slowly undergo a transition from a nematic (N) to a smectic-A (SmA) phase. Every shell has two antipodal +1 topological defects, at the thinnest and thickest points, respectively. On cooling from N to SmA, the symmetry axis connecting the defects gradually reorients from along gravity to perpendicular to it, reversibly and continuously, if the LC and aqueous phase are density matched at the N-SmA transition. This suggests reduced density near the defects—reflecting a local reduction in order—under the strong confinement with antagonistic boundary conditions. In the SmA phase, a regular array of focal conic domains (FCDs) develops, templated in position and orientation by the +1 defect at the thinnest point. Around this defect, a single complete toroidal FCD always develops, surrounded by incomplete FCDs. In contrast to similar FCD arrangements on flat aqueous interfaces, this is a stable situation, since the two +1 defects are required by the spherical topology. Our results demonstrate how the topological defects of LC shells can be used to template complex self-organized structures. With a suitable adaption of the LC chemistry, shells might serve as a basis for producing solid particles with complex yet highly regular morphologies.
Prunus lusitanica L.: An Endangered Plant Species Relict in the Central Region of Mainland Portugal
Authors: Raposo Mauro , Nunes Leonel , Quinto-Canas Ricardo , del Río Sara , Pardo Francisco , Galveias Ana , Pinto-Gomes Carlos
Published: August 2021

Prunus lusitanica L. is a paleotropical relic species with an Ibero-Maghrebian distribution, which is presently considered as an endangered species, recognized by the Natura 2000 Network (92/43/EEC) as a priority habitat for conservation in Europe. The mountains in the Portuguese mainland central region offer the best location for this species to occur. The main objective of this study is to measure the current conservation status of the communities of P. lusitanica, through the collection of field data, such as the number of existing individuals of each population and their location, which will then be comparatively analyzed based on the previous literature, published at least 15 years ago. Soil characterization analysis was carried out and the main threats to conservation were identified. As a result, a decline of approximately 40% was observed in the number of individuals and in the quality of their habitat. The main threats to their conservation were found to be the seasonal occurrence of rural fires and the expansion of invasive species, such as Acacia dealbata Link and Ailanthus altissima (Mill.) Swingle. Finally, we present the main management methodologies that should be considered for the valorization of this important vegetational relic in the central region of mainland Portugal.
Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats
Authors: Yairo Akira , Mandour Ahmed S. , Matsuura Katsuhiro , Yoshida Tomohiko , Ma Danfu , Kitpipatkun Pitipat , Kato Konosuke , Cheng Chieh-Jen , El-Husseiny Hussein M. , Tanaka Takashi , Shimada Kazumi , Hamabe Lina , Uemura Akiko , Takahashi Ken , Tanaka Ryou
Published: August 2021

Evaluation of diastolic function is a pivotal challenge due to limitations of the conventional echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular pressure difference (IVPD) and intraventricular pressure gradient (IVPG) in early diastole can be generated and are available as echocardiographic indices. These indices are expected to be useful for the early diagnosis of heart failure (HF), especially diastolic dysfunction. There have not been any studies demonstrating changes in IVPD and IVPG in response to changes in loading conditions in rats. Therefore, the present study aims to evaluate CMME-derived IVPD and IVPG changes in rats under various loading conditions. Twenty rats were included, divided into two groups for two different experiments, and underwent jugular vein catheterization under inhalational anesthetics. Conventional echocardiography, CMME, and 2D speckle tracking echocardiography were measured at the baseline (BL), after intravenous infusion of milrinone (MIL, n = 10), and after the infusion of hydroxyethyl starch (HES, n = 10). Left ventricular IVPD and IVPG were calculated from color M-mode images and categorized into total, basal, mid-to-apical, mid, and apical parts, and the percentage of the corresponding part was calculated. In comparison to the BL, the ejection fraction, mid-to-apical IVPG, mid IVPG, and apical IVPD were significantly increased after MIL administration (p < 0.05); meanwhile, the end-diastolic volume, E-wave velocity, total IVPD, and basal IVPD were significantly increased with the administration of HES (p < 0.05). The increase in mid-to-apical IVPD, mid IVPD, and apical IVPD indicated increased relaxation. A significant increase in basal IVPD reflected volume overloading by HES. CMME-derived IVPD and IVPG are useful tools for the evaluation of various loading conditions in rats. The approach used in this study provides a model for continuous data acquisition in chronic cardiac disease models without drug testing.
COVLIAS 1.0: Lung Segmentation in COVID-19 Computed Tomography Scans Using Hybrid Deep Learning Artificial Intelligence Models
Authors: Suri Jasjit S. , Agarwal Sushant , Pathak Rajesh , Ketireddy Vedmanvitha , Columbu Marta , Saba Luca , Gupta Suneet K. , Faa Gavino , Singh Inder M. , Turk Monika , Chadha Paramjit S. , Johri Amer M. , Khanna Narendra N. , Viskovic Klaudija , Mavrogeni Sophie , Laird John R. , Pareek Gyan , Miner Martin , Sobel David W. , Balestrieri Antonella , Sfikakis Petros P. , Tsoulfas George , Protogerou Athanasios , Misra Durga Prasanna , Agarwal Vikas , Kitas George D. , Teji Jagjit S. , Al-Maini Mustafa , Dhanjil Surinder K. , Nicolaides Andrew , Sharma Aditya , Rathore Vijay , Fatemi Mostafa , Alizad Azra , Krishnan Pudukode R. , Frence Nagy , Ruzsa Zoltan , Gupta Archna , Naidu Subbaram , Kalra Mannudeep
Published: August 2021

Background: COVID-19 lung segmentation using Computed Tomography (CT) scans is important for the diagnosis of lung severity. The process of automated lung segmentation is challenging due to (a) CT radiation dosage and (b) ground-glass opacities caused by COVID-19. The lung segmentation methodologies proposed in 2020 were semi- or automated but not reliable, accurate, and user-friendly. The proposed study presents a COVID Lung Image Analysis System (COVLIAS 1.0, AtheroPoint™, Roseville, CA, USA) consisting of hybrid deep learning (HDL) models for lung segmentation. Methodology: The COVLIAS 1.0 consists of three methods based on solo deep learning (SDL) or hybrid deep learning (HDL). SegNet is proposed in the SDL category while VGG-SegNet and ResNet-SegNet are designed under the HDL paradigm. The three proposed AI approaches were benchmarked against the National Institute of Health (NIH)-based conventional segmentation model using fuzzy-connectedness. A cross-validation protocol with a 40:60 ratio between training and testing was designed, with 10% validation data. The ground truth (GT) was manually traced by a radiologist trained personnel. For performance evaluation, nine different criteria were selected to perform the evaluation of SDL or HDL lung segmentation regions and lungs long axis against GT. Results: Using the database of 5000 chest CT images (from 72 patients), COVLIAS 1.0 yielded AUC of ~0.96, ~0.97, ~0.98, and ~0.96 (p-value < 0.001), respectively within 5% range of GT area, for SegNet, VGG-SegNet, ResNet-SegNet, and NIH. The mean Figure of Merit using four models (left and right lung) was above 94%. On benchmarking against the National Institute of Health (NIH) segmentation method, the proposed model demonstrated a 58% and 44% improvement in ResNet-SegNet, 52% and 36% improvement in VGG-SegNet for lung area, and lung long axis, respectively. The PE statistics performance was in the following order: ResNet-SegNet > VGG-SegNet > NIH > SegNet. The HDL runs in <1 s on test data per image. Conclusions: The COVLIAS 1.0 system can be applied in real-time for radiology-based clinical settings.
Diagnostic Performance of Artificial Intelligence-Based Computer-Aided Diagnosis for Breast Microcalcification on Mammography
Authors: Do Yoon Ah , Jang Mijung , Yun Bo La , Shin Sung Ui , Kim Bohyoung , Kim Sun Mi
Published: August 2021

The present study evaluated the diagnostic performance of artificial intelligence-based computer-aided diagnosis (AI-CAD) compared to that of dedicated breast radiologists in characterizing suspicious microcalcification on mammography. We retrospectively analyzed 435 unilateral mammographies from 420 patients (286 benign; 149 malignant) undergoing biopsy for suspicious microcalcification from June 2003 to November 2019. Commercial AI-CAD was applied to the mammography images, and malignancy scores were calculated. Diagnostic performance was compared between radiologists and AI-CAD using the area under the receiving operator characteristics curve (AUC). The AUCs of radiologists and AI-CAD were not significantly different (0.722 vs. 0.745, p = 0.393). The AUCs of the adjusted category were 0.726, 0.744, and 0.756 with cutoffs of 2%, 10%, and 38.03% for AI-CAD, respectively, which were all significantly higher than those for radiologists alone (all p < 0.05). None of the 27 cases downgraded to category 3 with a cutoff of 2% were confirmed as malignant on pathological analysis, suggesting that unnecessary biopsies could be avoided. Our findings suggest that the diagnostic performance of AI-CAD in characterizing suspicious microcalcification on mammography was similar to that of the radiologists, indicating that it may aid in making clinical decisions regarding the treatment of breast microcalcification.
Strengthening the Participation of Organisations of Persons with Disabilities in the Decision-Making of National Government and the United Nations: Further Analyses of the International Disability Alliance Global Survey
Authors: McVeigh Joanne , MacLachlan Malcolm , Ferri Delia , Mannan Hasheem
Published: August 2021

The participation of organisations of persons with disabilities (OPDs) is crucial at each stage of policy processes at the local, regional, and international levels. However, decision-making mechanisms have traditionally excluded OPDs, failing to consult with them on decisions that impact on their daily lives. The overall aim of this study was to examine the participation of persons with disabilities and OPDs in development programmes and policies by exploring recommendations from a sample of OPDs on ways to strengthen their participation with government and the UN. Secondary data analysis was conducted using a global survey on the participation of OPDs, administered by the International Disability Alliance to OPD representatives. Two open-ended items were analysed, which explored participants’ recommendations on ways to strengthen their participation with government and the UN. Data were analysed using the descriptive and interpretive qualitative methods. Respondents provided recommendations on how to strengthen their participation with their national government and the UN, focusing on several issues including accessibility, human rights, and the need for inclusion of all OPDs and all groups of persons with disabilities. The synergy between the Convention on the Rights of Persons with Disabilities and the Sustainable Development Goals presents opportunities for OPDs to increase their participation in development policies and programmes. It is vital, however, to dismantle the barriers to participation in decision-making by OPDs and persons with disabilities.
The Performance of Satellite-Based Links for Measurement-Device-Independent Quantum Key Distribution
Authors: Huang Guoqi , Dong Qin , Cui Wei , Jiao Rongzhen
Published: August 2021

Measurement-device-independent quantum key distribution (MDI-QKD) protocol has high practical value. Satellite-based links are useful to build long-distance quantum communication network. The model of satellite-based links for MDI-QKD was proposed but it lacks practicality. This work further analyzes the performance of it. First, MDI-QKD and satellite-based links model are introduced. Then considering the operation of the satellite the performance of their combination is studied under different weather conditions. The results may provide important references for combination of optical-fiber-based links on the ground and satellite-based links in space, which is helpful for large-scale quantum communication network.
Activated Carbon from Corncobs Doped with RuO2 as Biobased Electrode Material
Authors: Hoffmann Viola , Rodriguez Correa Catalina , Sachs Saskia , del Pilar Sandoval-Rojas Andrea , Qiao Mo , Brown Avery , Zimmermann Michael , Rodriguez Estupiñan Jenny , Cortes Maria , Moreno-Piraján Juan , Titirici Maria-Magdalena , Kruse Andrea
Published: August 2021

Bio-based activated carbons with very high specific surface area of >3.000 m² g−1 (based on CO2 adsorption isotherms) and a high proportion of micropores (87% of total SSA) are produced by corncobs via pyrolysis and chemical activation with KOH. The activated carbon is further doped with different proportions of the highly pseudocapacitive transition metal oxide RuO2 to obtain enhanced electrochemical properties and tune the materials for the application in electrochemical double-layer capacitors (EDLC) (supercapacitors). The activated carbon and composites are extensively studied regarding their physico-chemical and electrochemical properties. The results show that the composite containing 40 wt.% RuO2 has an electric conductivity of 408 S m−1 and a specific capacitance of 360 Fg−1. SEM-EDX, XPS, and XRD analysis confirm the homogenous distribution of partly crystalline RuO2 particles on the carbon surface, which leads to a biobased composite material with enhanced electrochemical properties.
On-Line Control of Stresses in the Power Unit Pressure Elements Taking Account of Variable Heat Transfer Conditions
Authors: Rusin Andrzej , Tomala Martyna , Łukowicz Henryk , Nowak Grzegorz , Kosman Wojciech
Published: August 2021

Coal-fired power units, now balancing power shortages in the power system, must be characterised by increasingly higher flexibility of operation. This means faster start-ups and the capacity for frequent decreases and increases in the power output. These processes cause large temperature gradients in elements of the power unit and the turbine and lead to an increase in the stress level. At such an operating regime it is impossible to ensure safety based on start-up characteristics only—it becomes necessary to constantly monitor stress levels in critical areas of machinery and equipment elements. The stress level in turbine elements can be monitored on-line using algorithms based on Green’s functions and Duhamel’s integral. This paper presents examples of modifications of stress calculations in turbine valves and casings during start-ups. By modifying basic algorithms, it is possible to take into account the impact of the variability of heat transfer coefficients on the thermal stress level. Additionally, individual Green’s functions and correction factors were determined for specific stages of start-ups. Due to modifications, it is possible to obtain satisfactory agreement with the results obtained from FEM-based calculations for the entire heating process. Equations are also given that enable estimation of values of the heat transfer coefficient in turbine valves. The proposed modification of the algorithm will substantially improve the accuracy of stress modelling in transient states of the turbine operation. On-line stress monitoring will enable an increase in the flexibility of the power unit operation and facilitate operational control, ensuring safety of individual elements at the same time. The stress values calculated in the on-line mode can also be used to estimate fatigue life consumption and forecast the residual lifetime of individual components.