bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy
Authors: Fassio A. , Porciello G. , Carioli G. , Palumbo E. , Vitale S. , Luongo A. , Montagnese C. , Prete M. , Grimaldi M. , Pica R. , Rotondo E. , Falzone L. , Calabrese I. , Minopoli A. , Grilli B. , Cuomo M. , Fiorillo P.C. , Evangelista C. , Cavalcanti E. , De Laurentiis M. , Cianniello D. , Pacilio C. , Pinto M. , Thomas G. , Rinaldo M. , D’Aiuto M. , Serraino D. , Massarut S. , Steffan A. , Ferraù F. , Rossello R. , Messina F. , Catalano F. , Adami G. , Bertoldo F. , Libra M. , Crispo A. , Celentano E. , La Vecchia C. , Augustin L.S.A. , Gatti D.
Published: March 2024

Objective. To report cross-sectionally serum levels of 25-hydroxyvitamin D [25(OH)D] in women living in Italy within 12 months from breast cancer (BC) diagnosis.
Methods. Baseline data were obtained from 394 women diagnosed with primary BC, enrolled from 2016 to 2019 in a lifestyle trial conducted in Italy. Subjects’ characteristics were compared between two 25(OH)D concentrations (hypovitaminosis D<20 and ≥20 ng/mL) with the Chi-squared test or Fisher’s exact test for small-expected counts. Using multiple logistic regression-adjusted models, we estimated odds ratios (ORs) of hypovitaminosis D with 95% confidence intervals (CIs) in the total sample and in the unsupplemented subgroup.
Results. Hypovitaminosis D was found in 39% of all subjects, 60% in unsupplemented subjects, and 10% in supplemented subjects. Increasing ORs of hypovitaminosis D were found with increasing body mass index, 25-30, >30, and ≥35 versus <25 kg/m2 (ORs: 2.50, 4.64, and 5.81, respectively, in the total cohort and ORs: 2.68, 5.38, and 7.08 in the unsupplemented); living in the most southern Italian region (OR 2.50, 95%CI 1.22-5.13); and with hypertriglyceridemia (OR 2.46; 95%CI 1.16-5.22), chemotherapy history (OR 1.86, 95%CI 1.03-3.38), and inversely with anti-estrogenic therapy (OR 0.43, 95%CI 0.24-0.75) in the total sample.
Conclusions. Hypovitaminosis D in women recently diagnosed with BC and participating in a lifestyle trial in Italy was widespread and highest with obesity, hypertriglyceridemia, and chemotherapy use. Considering that hypovitaminosis D is a risk factor for lower efficacy of bone density treatments and possibly BC mortality, our results suggest the need to promptly address and treat vitamin D deficiency.
Neurological features of Paget’s disease of bone
Authors: Ridah Wassima , Nassar Kawtar , Zaher Soukaina , Janani Saadia
Published: March 2024

Paget’s disease of bone is a chronic focal disorder characterized by disorganized bone remodeling. It is usually asymptomatic and the diagnosis is made incidentally on the basis of other medical problem investigations. Head bones are frequently affected and may cause deformities due to overgrowth of bone leading to neurological manifestations such as headaches, dizziness, and deafness. Here, we describe a case of a 72-year-old woman who complained of headaches, back pain, tinnitus, and hearing loss. Clinical examination showed spinal deformities. Laboratory tests revealed elevated bone remodeling markers. Head computed tomography scan showed bone lesions suggesting Paget’s disease. Isotope bone scan revealed uptake in skull and thoracic spine. The patient was treated with zoledronic acid and analgesic with significant improvement of headaches and back pain and persistence of hearing loss.
Effect of diabetes mellitus on treatment response in locally advanced carcinoma cervix patients
Authors: Shah Afsana , Kumar Dinesh , Meedimale Santhosh , Kaur Harleen , Shukla Pragya
Published: March 2024

Aim:

To study the effect of type 2 diabetes mellitus (T2DM) on treatment response in locally advanced carcinoma cervix patients receiving chemo-radiotherapy.

Materials and Methods:

A retrospective study was done in locally advanced carcinoma cervix patients also affected with T2DM in the Indian population, and a sample was collected from 2016 to 2018.

Results:

On analysis, 8.2% of patients were found to have T2DM, 4.9% of patients were found to have T2DM and hypertension, 12.56% of patients were found to have hypertension, and 74.31% of patients had no comorbidity. Patients with diabetes and diabetes plus hypertension have 25% cases of residual and 37.5% cases of recurrence, whereas patients with no comorbidity, 14.7% have residual and 16.91% have recurrence.

Conclusion:

In this retrospective study, we found that patients of carcinoma cervix with diabetes mellitus and diabetes plus hypertension had poor responses to radiation resulting in more cases of residual and recurrences due to the multitude of effects of diabetes on the body. Hypertension alone did not affect the treatment response to radiation.
A Clinical Trial Examined the Effectiveness of Curcumin and Vitamin C Sheets as Local Medicine Delivery Agents in Addition to Scaling and Root Planning
Authors: Sharma Ankita , Chauhan Shailendra S , Sinha Aditya , Sharma Satendra , Kumari Radha
Published: March 2024

Aim:

The aim of this study was to assess the effectiveness of using Vitamin C and curcumin sheets applied subgingivally in combination with scaling and root planing (SRP). Patients age between 35 and 60 would be included, a total of 45 sites divided into three groups which are distributed as follows: Group I – (SRP) alone, Group II (SRP) with Vitamin C sheet, and Group III (SRP) with curcumin sheet

Results:

The mean gingival index (GI) scores for Group I were 2.60, 0.51, 0.93, 0.26, and 1.00, respectively, at baseline, 15 days, and 30 days. At baseline, the mean GI score in Group II decreased from 2.53 ± 0.52 to 0.67 ± 0.49 at 45 days. In line with this, Group III saw a decrease in the mean GI score from 3.00 ± 0.00 at baseline to 0.20 ± 0.41 at 45 days. At different points, each group showed a statistically significant difference. In Group III, the mean plaque index score dropped from 3.00 ± 0.00 at baseline to 0.27 ± 0.46 at 30 days. Only Group III showed a statistically significant difference at various periods. Probing pocket depth intergroup comparisons for all groups were found to be statistically significant.

Conclusion:

According to the study’s findings, SRP in combination with Vitamin C and curcumin sheets improved periodontal markers and had a positive impact on individuals with chronic periodontitis.
Rhesus alloimmunization is correlated to necrotizing enterocolitis and respiratory distress: A tertiary center experience
Authors: Elsaidawi Weam , Hallak Hana , Alsadoun Abulaziz , Alodah Nora , Alalaiyan Saleh , Binmanee Abdulaziz , Jabr Mohammad Bin , Kattan Abdulhakiem , Almidani Eyad
Published: March 2024

Background

Rh alloimmunization occurs in pregnant women who do not express the red blood cell Rh antigen phenotype but carry a fetus that does. The mainstay of treatment is intrauterine blood transfusion (IUT). Necrotizing enterocolitis (NEC) is a rapidly progressive and life-threatening emergency that most commonly affects preterm neonates. It has been noticed that NEC has a predilection toward neonates with rhesus hemolytic disease (RHD) compared to neonates without RHD, particularly among the late preterm to near-term population with a moderate to severe grade of RHD.

Methodology

This is a retrospective cohort study that included all neonates delivered in our hospital between January 2015 and December 2021,who received IUT due to Rh-isoimmunization, and the control group consisted of neonates, who did not have Rh-isoimmunization and no history of IUT. Neonates were excluded from the study if they met our exclusion criteria.

Results

During a 7-year study period, a total of 144 neonates were included in the study. Of those, 72 neonates had RHD and received IUT (group 1), while 72 neonates did not have RH isoimmunization and did not receive IUT (group 2). Maternal and neonatal demographic data were similar between the two groups, except for birth weight, which was higher in group 1 (2.49 vs. 2.31 kg, P = 0.025). Ten cases developed NEC (13.89%) in group 1, while there were no cases of NEC in the other group (P = 0.001). We also found that the initial hemoglobin level was lower in group 1 (135.4 vs. 174.3 g/dL) with a P value of <0.001. The duration of respiratory support was significantly higher in group 1 (2.27 vs. 0.319 days; P = 0.006). Neonatal sepsis was more in group 1 (19.44 vs. 1.39%; P = 0.002). There was no significant difference between the two groups in terms of respiratory distress syndrome, intraventricular hemorrhage, and retinopathy of prematurity.

Conclusion

Neonates with rheus hemolytic disease (RHD) who undergo IUT are at a higher risk of developing NEC and prolonged course of respiratory support. Extra cautions may be necessary when advancing feeding in these patients.

A well-designed multicenter prospective trial with an adequate sample size is recommended to validate our result.
Assessment of Eustachian Tube Function for Successful Tympanoplasty in Chronic Otitis Media
Authors: Hiremath Basavaraj
Published: March 2024

Introduction:

Eustachian tube function (ETF) has been the focus of attention as a prognostic factor for successful tympanoplasty surgery, due to its supposed primary pathogenic role in otitis media. Poor Eustachian tube (ET) function has been blamed to many diseases of middle ear cleft extending from serous otitis media to the squamosal type of chronic otitis media (COM). The objective of this study was to evaluate the effect of ETF on tympanoplasty outcome in the mucosal type of COM patients.

Materials and Methods:

An observational study was conducted for the patients admitted to the department of ENT and HNS with COM, mucosal type. The study was done from April 2021 to March 2022. ETF was assessed with the Toynbee test and saccharin time test.

Results:

The mean saccharin clearance time was found to be 17 min. Tympanoplasty was performed on 55 patients; 91.1% of patients showed successful outcome with good graft uptake who had normal ETF; out of 20 patients with partial dysfunction, 12 patients had successful graft uptake, and eight patients showed graft rejection.

Conclusion:

The automatic Toynbee test can be a practical, objective, and suitable method to assess the ventilatory function of ET. The saccharin test is an easy, cost-effective, and useful diagnostic tool to assess the mucociliary function of the ET. The ventilatory function of ET which is the single most important contributory factor in the pathogenesis of COM should be evaluated with the objective method before tympanoplasty.
Evaluation of Serum 25-Hydroxyvitamin D Levels in Benign Paroxysmal Positional Vertigo Patients
Authors: Dhanapal Pradeep , Iyachamy Bharat , Lakshmanan Somu
Published: March 2024

Background:

Benign paroxysmal positional vertigo (BPPV) is characterized by the occurrence of a rotational type of vertigo and nystagmus due to the otoconia dislodgment from the utricle into semicircular canals. Repeated vertigo attacks reduce the quality of life by affecting the normal daily activities in the population of all age groups. The most accepted theory for BPPV is the displaced otoconia particle, which aggravates vertigo and nystagmus. The otoconia is made of calcium carbonate, which is regulated by calcium homeostasis. Vitamin D receptors are essential for calcium regulation and homeostasis.

Objectives:

The objectives of this study are to estimate the serum 25-hydroxyvitamin D levels in BPPV patients and compare them with the healthy participants/control.

Materials and Methods:

This study was conducted in a tertiary care hospital in south India. In Group A (case group), patients diagnosed with BPPV were included and their serum 25-hydroxyvitamin D levels were measured and compared with the healthy individuals’ serum 25-hydroxyvitamin D levels in Group B (control group).

Results:

This study showed no significant difference in age and gender between the two groups (P = 0.99 and 0.323, respectively). The serum 25-hydroxyvitamin D levels were lower in Group A than in Group B (P = 0.005). The prevalence of Vitamin D deficiency in Group A was higher than that in Group B.

Conclusion:

There is an association between 25-hydroxyvitamin D levels and BPPV patients. Further studies on Vitamin D supplementation in BPPV patients with long-term follow-up will be beneficial to know whether Vitamin D deficiency is an associated risk factor for BPPV.
Small Fenestra Stapedotomy in Comparison to Large Fenestra Stapedectomy in Improving Hearing Loss Caused by Otosclerosis: A Retrospective Study
Authors: Kumar Pankaj , Chhabra Biban , Gupta Ajay Kumar , Tamrakar Akshay , Kumar Pallika
Published: March 2024

Background:

A retrospective study done on all otosclerotic patients who underwent stapes surgery between January 2019 and June 2022 in the department of otorhinolaryngology in a tertiary care hospital in North India.

Material and Methods:

Fifty four patients were enrolled in the study. The inclusion criteria of the study included patients in the age group of 18–55 years with conductive hearing loss and an intact tympanic membrane and an air–bone gap (ABG) of more than 30 dB. Diagnosis of otosclerosis is based on clinical history of progressive hearing loss and audiometric evaluation. Pure Tone Average shows typical conductive hearing loss pattern.

Aim and Objective:

Preoperative and 6 months postoperative audiological evaluation was conducted to understand the difference in hearing. The same surgical technique was used in all the cases, except that the dimension of the foot plate removed was different.

Results:

The mean age of patients in years who underwent stapes surgery was 31.6 ± 6.4 years. Out of the 54 patients, 24 (44.44%) were male and 30 (55.56%) were female. The number of patients who underwent large fenestra stapedectomy was 30 (55.56%) and who underwent small fenestra stapedotomy was 24 (44.44%). There was a significant improvement in the hearing parameters (PTA and ABG) in both the groups after surgery, but there was no significant difference between the small fenestra and large fenestra groups in terms of improvement in PTA and ABG.

Conclusion:

In conclusion, both small fenestra stapedotomy and large fenestra stapedectomy are safe and effective procedures for improving conductive hearing loss in otosclerosis patients.
Ultrasound in Female Urinary Incontinence
Authors: Yang Jenn-Ming , Huang Wen-Chen
Published: March 2024

Urinary incontinence (UI) is a common health condition that may interfere with the quality of life. A comprehensive evaluation of female UI helps with effective and safe treatments. Ultrasound has gained popularity to explore UI recently because it can collect crucial information for treatment planning and counseling. Translabial and introital approaches are commonly and reliably applied to ultrasound. The images can be obtained using two-dimensional and three-dimensional ultrasounds. Ultrasound is the only modality capable of confirming the presence or absence of a mid-urethral sling (MUS) and is able to demonstrate bulking agents as well. Although some of the ultrasound findings may only be incidental or supplementary to the patient’s symptoms, ultrasound benefits for investigating the pathophysiology of UI and surgical outcomes of MUS procedures. It is anticipated that standardization in terminology, measurement techniques, and reporting can be established in the near future.
Feasibility of Ultrasonic Heating through Skull Phantom Using Single-element Transducer
Authors: Antoniou Anastasia , Damianou Christakis
Published: March 2024

Background:

Noninvasive neurosurgery has become possible through the use of transcranial focused ultrasound (FUS). This study assessed the heating ability of single element spherically focused transducers operating at 0.4 and 1.1 MHz through three-dimensional (3D) printed thermoplastic skull phantoms.

Methods:

Phantoms with precise skull bone geometry of a male patient were 3D printed using common thermoplastic materials following segmentation on a computed tomography head scan image. The brain tissue was mimicked by an agar-based gel phantom developed in-house. The selection of phantom materials was mainly based on transmission-through attenuation measurements. Phantom sonications were performed through water, and then, with the skull phantoms intervening the beam path. In each case, thermometry was performed at the focal spot using thermocouples.

Results:

The focal temperature change in the presence of the skull phantoms was reduced to less than 20 % of that recorded in free field when using the 0.4 MHz transducer, whereas the 1.1 MHz trans-skull sonication produced minimal or no change in focal temperature. The 0.4 MHz transducer showed better performance in trans-skull transmission but still not efficient.

Conclusion:

The inability of both tested single element transducers to steer the beam through the high attenuating skull phantoms and raise the temperature at the focus was confirmed, underlying the necessity to use a correction technique to compensate for energy losses, such those provided by phased arrays. The proposed phantom could be used as a cost-effective and ergonomic tool for trans-skull FUS preclinical studies.
Predictive Modelling for Parkinson's Disease Diagnosis using Biomedical Voice Measurements
Authors: Dahiya Ruby , Dahiya Virendra Kumar , Deepakshi  , Agarwal Nidhi , Maguluri Lakshmana Phaneendra , Muniyandy Elangovan
Published: March 2024

INTRODUCTION: Parkinson's Disease (PD), a progressively debilitating neurological disorder impacting a substantial global population, stands as a significant challenge in modern healthcare. The gradual onset of motor and non-motor symptoms underscores the criticality of early detection for optimal treatment outcomes. In response to this urgency, novel avenues for early diagnosis are being explored, where the amalgamation of biomedical voice analysis and advanced machine learning techniques holds immense promise. Individuals afflicted by PD experience a nuanced deterioration of bodily functions, necessitating interventions that are most effective when initiated at an early stage. The potential of biomedical voice measurements to encode subtle health indicators presents an enticing opportunity. The human voice, an intricate interplay of frequencies and patterns, might offer insights into the underlying health condition.
OBJECTIVES: This research embarks on a comprehensive journey to delve into the intricate connections between voice attributes and the presence of PD, with the aim of expediting its detection and treatment.
METHODS: At the heart of this exploration is the Support Vector Machine (SVM) model, a versatile machine learning tool [1-2]. Functioning as a virtual detective, the SVM model learns from historical data to decipher the intricate patterns that differentiate healthy individuals from those with PD [3-4].
RESULTS: Through the power of pattern recognition, the SVM becomes a predictive instrument, a potential catalyst in unravelling the latent manifestations of PD using the unique patterns harbored within the human voice. Embedded within this research are the practical demonstrations showcased through code snippets [5-7]. By synergizing the intricate voice measurements with the SVM model, we envision the emergence of a diagnostic paradigm where early PD detection becomes both accessible and efficient. This study not only epitomizes the synergy of voice and machine interactions but also attests to the transformative potential of technology within the domain of healthcare. .
CONCLUSION: Ultimately, this research strives to harness the intricate layers of voice data, as exemplified through the provided model code [8-11], to contribute to the evolution of an advanced tool for PD prediction. By amalgamating the principles of machine learning and biomedical analysis, we aspire to expedite early PD diagnosis, thereby catalyzing more efficacious treatment strategies. In traversing this multidimensional exploration, we aspire to pave the path toward a future where technology plays an instrumental role in enhancing healthcare outcomes for individuals navigating the challenges of PD, ultimately advancing the pursuit of early diagnosis and intervention.
Research on Power Load Data Acquisition and Integrated Transmission Systems in Electric Energy Calculation and Detection
Authors: Dang Sanlei , Wei Fusheng , Wu Min , Xie Ruibiao , Wu Jintao
Published: March 2024

This paper presents the crucial area of power load data acquisition with an integrated transmission system for precise calculation and detection of electric energy. With the advances in technology, management and optimization of energy has become critical for sustainability and economic reasons. Thus, we have targeted the cutting-edge methods for data gathering of power load along with its efficient transmission previously reviewed. We scrutinized the current methods and technologies used in power load data acquisition and identified their limitations along with areas of improvements. We followed advanced sensors and measuring devices for data collection employed an integrated transmission system with up-to-the-minute communication protocols and data processing algorithms. These were experimentally verified to improve the accuracy and reliability of the electric energy calculations. The real-world case studies were included for its practical implementations to provide an insight into its impacts. The results of this study provide a maturing outlook along with valuable analysis for electric energy calculation and detection. The system due to its potential for enhancing the energy management and efficiency can have a real-life and profound significance in sustainable and economic handling of the increasing load of energy.
The harmonic $H^{\infty}$-functional calculus based on the $S$-spectrum
Authors: De Martino Antonino , Pinton Stefano , Schlosser Peter
Published: March 2024

The aim of this paper is to introduce the

H^{\infty}

-functional calculus for harmonic functions over the quaternions. More precisely, we give meanring to

Df(T)

for unbounded sectorial operators

T

and polynomially growing functions of the form

Df

, where

f

is a slice hyperholomorphic function and

D=\partial_{q_0}+e_{1}\partial_{q_1}+e_{2}\partial_{q_2}+e_{3}\partial_{q_3}

is the Cauchy–Fueter operator. The harmonic functional calculus can be viewed as a modification of the well-known

S

-functional calculus

f(T)

, with a different resolvent operator. The harmonic

H^{\infty}

-functional calculus is defined in two steps. First, for functions with a certain decay property, one can make sense of the bounded operator

Df(T)

directly via a Cauchy-type formula. In a second step, a regularization procedure is used to extend the functional calculus to polynomially growing functions and consequently unbounded operators

Df(T)

. The harmonic functional calculus is an important functional calculus of the quaternionic fine structures on the

S

-spectrum, which arise also in the Clifford setting and they encompass a variety of function spaces and the corresponding functional calculi. These function spaces emerge through all possible factorizations of the second map of the Fueter–Sce extension theorem. This field represents an emerging and expanding research area that serves as a bridge connecting operator theory, harmonic analysis, and hypercomplex analysis.
O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells
Authors: Zhou Xu-Chang , Ni Guo-Xin
Published: March 2024

Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.
High glucose microenvironment and human mesenchymal stem cell behavior
Authors: Mateen Muhammad Abdul , Alaagib Nouralsalhin , Haider Khawaja Husnain
Published: March 2024

High glucose (HG) culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells, analogous to any other cell type in our body. It interferes with diverse signaling pathways, i.e. mammalian target of rapamycin (mTOR)-phosphoinositide 3-kinase (PI3K)-Akt signaling, to impact physiological cellular functions, leading to low cell survival and higher cell apoptosis rates. While elucidating the underlying mechanism responsible for the apoptosis of adipose tissue-derived mesenchymal stem cells (MSCs), a recent study has shown that HG culture conditions dysregulate mTOR-PI3K-Akt signaling in addition to mitochondrial malfunctioning due to defective mitochondrial membrane potential (MtMP) that lowers ATP production. This organelle-level dysfunction energy-starves the cells and increases oxidative stress and ultrastructural abnormalities. Disruption of the mitochondrial electron transport chain produces an altered mitochondrial NAD+/NADH redox state as evidenced by a low NAD+/NADH ratio that primarily contributes to the reduced cell survival in HG. Some previous studies have also reported altered mitochondrial membrane polarity (causing hyperpolarization) and reduced mitochondrial cell mass, leading to perturbed mitochondrial homeostasis. The hostile microenvironment created by HG exposure creates structural and functional changes in the mitochondria, altering their bioenergetics and reducing their capacity to produce ATP. These are significant data, as MSCs are extensively studied for tissue regeneration and restoring their normal functioning in cell-based therapy. Therefore, MSCs from hyperglycemic donors should be cautiously used in clinical settings for cell-based therapy due to concerns of their poor survival rates and increased rates of post engraftment proliferation. As hyperglycemia alters the bioenergetics of donor MSCs, rectifying the loss of MtMP may be an excellent target for future research to restore the normal functioning of MSCs in hyperglycemic patients.
Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease
Authors: Park Min Young , Yoon Yong Sik , Park Jae Ha , Lee Jong Lyul , Yu Chang Sik
Published: March 2024

BACKGROUND

Stem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease (CD). Anti-tumor necrotic factor (TNF) therapy combined with drainage procedure is effective as well. However, previous studies are limited to proving whether the combination treatment of biologics and stem cell transplantation improves the effect of fistula closure.

AIM

This study aimed to evaluate the long-term outcomes of stem cell transplantation and compare Crohn’s perianal fistula (CPF) closure rates after stem cell transplantation with and without anti-TNF therapy, and to identify the factors affecting CPF closure and recurrence.

METHODS

The patients with CD who underwent stem cell transplantation for treating perianal fistula in our institution between Jun 2014 and December 2022 were enrolled. Clinical data were compared according to anti-TNF therapy and CPF closure.

RESULTS

A total of 65 patients were included. The median age of females was 26 years (range: 21-31) and that of males was 29 (44.6%). The mean follow-up duration was 65.88 ± 32.65 months, and complete closure was observed in 50 (76.9%) patients. The closure rates were similar after stem cell transplantation with and without anti-TNF therapy (66.7% vs 81.6% at 3 year, P = 0.098). The patients with fistula closure had short fistulous tract and infrequent proctitis and anorectal stricture (P = 0.027, 0.002, and 0.008, respectively). Clinical factors such as complexity, number of fistulas, presence of concurrent abscess, and medication were not significant for closure. The cumulative 1-, 2-, and 3-year closure rates were 66.2%, 73.8%, and 75.4%, respectively.

CONCLUSION

Anti-TNF therapy does not increase CPF closure rates in patients with stem cell transplantation. However, both refractory and non-refractory CPF have similar closure rates after additional anti-TNF therapy. Fistulous tract length, proctitis, and anal stricture are risk factors for non-closure in patients with CPF after stem cell transplantation.
Prawo propinacyjne Galicji. Zarys problematyki
Authors: Kluss Maciej
Published: March 2024

The propination rights provided for the exclusive right to produce and sell alcoholic beverages. In the 19th century, however, these rights, together with the serfdom, became a relic of a bygone era, having no place in the existing social and legal system, which ultimately led to its abolition. The article presents research problems related to the propination rights in Galicia. The first part of the article presents the definition and nature of propination in Poland, its connection to the feudal system and the phenomenon of forced propination. The second part of the article discusses the propination rights in Galicia during the first half of the 19th century, taking into account social, political and legal factors. It presents the issue of propination during the period of Galician autonomy in the second half of the 19th century as well. This part includes also issues of competent authorities and the ultimate abolition of these rights on the basis of the Act of December 30, 1875, and the Act of April 22, 1889.
Nieznane protokoły posiedzeń podkomisji prawa o stosunkach z pokrewieństwa i opieki Komisji Kodyfikacyjnej Rzeczypospolitej Polskiej z 1939 roku (część IV)
Authors: Mikołajczyk Marian , Nancka Grzegorz
Published: March 2024

Lost Minutes of the Sittings of the Sub-commission on the Law on Kinship and Care Relationships of the Codification Commission of the Republic of Poland in 1939 (Part IV)

When Poland regained independence in 1918, the different legal systems of the various partitioning states all remained in force on its territory. Drafts of uniform laws were to be drawn up by the Codification Commission established in 1919. One of its tasks was the preparation of a draft of the family and guardianship law. The sub-commission addressing this division of civil law worked until the outbreak of World War Two. The minutes of its sittings disappeared in September 1939 along with the total output of the Codification Commission. However, copies of minutes of the sittings of the subcommission held in 1939 were found in Kazimierz Przybyłowski’s collection of books donated to the Faculty of Law and Administration of University of Silesia in Katowice. These minutes shed new light on the final phase of the codification works. Publication of these documents will enable further detailed research on the history of family law in interwar Poland. The fourth part of the publication consists of minutes nos. 197–201, and includes the reconstruction of articles 1–16, 40–58, and the draft of articles 59–78a as well.
Detecting spelling errors in Vietnamese administrative document using large language models
Authors: Phung Huan The , Luong Nghia Van
Published: March 2024

In the context of the emergence of more and more administrative documents, the need to ensure accuracy and improve the quality of these documents becomes increasingly important. This research focuses on applying advanced language models to detect spelling errors in administrative documents. Specifically, in this study, a new method using a language model based on the Transformers architecture is proposed to automatically detect and correct common spelling errors in administrative documents. This method combines the model’s ability to understand context and grammar to identify words or phrases that are likely to be misspelled. The proposed method is tested on a dataset containing real administrative documents, and the experimental results show that the proposed model is capable of detecting spelling errors with significant performance, helping to improve accuracy. and improve the quality of administrative documents. This research not only contributes to improving the quality of administrative documents but also opens up new research directions in applying language models to issues related to natural language processing in the field of administration.
The Impact of Political Identity on Candidate Electability in Village Head Elections
Authors: Misbahuddin Misbahuddin , Hawing Hardianto , Muhiddin Amir
Published: March 2024

This study examines the partial and simultaneous impact of Identity Politics on the Electability of Village Head Candidates in Layoa Village, Gantarang Keke District, Bantaeng Regency. The research used a quantitative approach with descriptive research type. The sampling technique used was saturated sampling with the use of Likert scale instruments, and the data were analyzed using descriptive statistical techniques and simple regression analysis with the help of SPSS software version 26. The results showed that partially, the legitimacy identity indicator (X1) had an impact of 49.9%, resistance identity (X2) of 64.2%, and project identity (X3) had an impact of 66.2% on the electability of Village Head Candidates. The impact is measured through simple regression for each identity indicator. Simultaneously, Political Identity significantly affects the electability of Village Head Candidates, as indicated by the Fcount value of 916.773 with a significance level of 0.000, smaller than 0.05. The magnitude of the variable's impact is measured by the R Square value of 0.908, which means that 90.8% of the variation in electability can be explained by the Identity Politics variable. The remaining 9.2% is attributable to other factors not examined in this study.
Political Culture of The Community in The Village Head Election in Barua, Indonesia
Authors: Julianto Saldi , Hamrun Hamrun , Akbar Muhammad Randhy
Published: March 2024

This study employs community groupings based on categories of political culture to discern the political inclinations of Barua Village residents during the 2021 Pilkades in Barua Village, Eremerasa District, Bantaeng Regency. Employing descriptive research with a qualitative approach, the study methodology entails collecting observational data in the form of word lists devoid of categorization structures, followed by qualitative data analysis. Various methods, such as documentation, interviews, and observation, are utilized for qualitative data collection. Qualitative data, consisting of textually arranged words, is expanded without reliance on mathematical calculations or statistics for analysis. Through the classification of individuals based on their political cultures, this research aims to provide a comprehensive understanding of the community's political awareness and engagement levels. The study findings suggest a prevalent tendency among the Barua village community towards participant and subject political culture, evidenced by their robust political awareness, active involvement in the Pilkades process, and nuanced understanding of effective leadership. While individuals exhibit awareness of their political choices, some remain disengaged and apathetic towards political activities.
EVALUATION OF THE STATUS OF HEALTH INFRASTRUCTURE IN INDIA WITH SPECIAL REFERENCE TO BIHAR & JHARKHAND
Authors: Gupta Dr. Renu
Published: March 2024

Health infrastructure plays a crucial role to achieve the target ‘Health for All’. During the time frame of 2019 to 2021, Jharkhand has shown a greater improvement than Bihar in terms of percentage change, with a 67% rise in the total number of Primary Health Centers (PHCs). However, Bihar has a higher total number of operational PHCs, with 2034 in total. India had a 5% increase in Community Health Centers (CHCs) between 2019 and 2021, with the most significant expansion seen in Bihar, where there was an impressive 104% increase. The Scheduled Castes (SCs) of Bihar have had a significant 4% increase in population from 2019 to 2021, whereas Jharkhand has witnessed a 6% growth within the same time frame. It is essential to provide more healthcare services through public health care system in order to safeguard the well-being and survival of all individuals.
El control inventarios en el volumen de ventas de las farmacias de Portoviejo
Authors: Zambrano Arteaga María Belen , Mera Plaza Carmen Liliana
Published: March 2024

En un entorno empresarial donde la eficiencia operativa y la capacidad de respuesta al mercado son cruciales, este estudio se enfoca en las redes de Farmacias San Gregorio de Portoviejo para examinar el impacto de la gestión de inventarios en el incremento de las ventas. Con el propósito de entender cómo las estrategias de control de inventario pueden influir directamente en el rendimiento comercial, se adopta una metodología transversal no experimental de nivel descriptivo correlacional. A partir de una muestra representativa de 20 empleados y utilizando un cuestionario tipo Likert. Los resultados destacan prácticas de gestión consistentes en el control de inventarios, manifestadas a través de una distribución simétrica y variabilidad moderada, contrastando con un volumen de ventas que tiende hacia valores más bajos y muestra menor variabilidad. Esta tendencia sugiere un mercado potencialmente conservador y destaca la importancia de adaptar las estrategias de valuación de inventarios a factores empresariales específicos. Además, se observa una correlación significativa entre el uso de sistemas de registro y evaluación, lo que resalta la importancia de la gestión de datos y la inteligencia empresarial en la toma de decisiones eficientes en el sector farmacéutico.
UTICAJ COVID-19 PANDEMIJE NA KONZUMACIJU ALKOHOLA I CIGARETA KOD ADOLESCENATA NA TERITORIJI OPŠTINE DOLJEVAC
Authors: Bogoslovic Milos , Dragana Mitrović , Vladana Nikolić , Milica Jovanović , Spasić Darko
Published: March 2024

Uvod: Mere socijalnog distanciranja tokom pandemije bolesti korona virusa 2019 (COVID-19) dovele su do psihičke patnje među adolescentima, što je dovelo do rizične konzumacije psihoaktivnih supstanci kao što su duvan i alkohol.
Cilj: Identifikovati promene u navikama konzumacije duvana i alkoholola usled izolacije COVID-19 2020.godine u grupi adolescenata završnog razreda osnovne škole na teritoriji opštine Doljevac.
Metodologija: Rađena su dva istraživanja u periodu od oktobara do novembra 2022.godine nakon COVID19 pandemije, od kojih je prvo bilo usmereno na ispitivanje učestalosti upotrebe cigareta, a drugo na ispitivanje učestalosti upotrebe alkohola na uzorku učenika osmog razreda osnovne škole, oba pola, ukupno 82 ispitanika..
Rezultati: Cigarete je probalo više od jedne četvrtine ispitanika 26,18%. Trenutno cigarete koristi 2,44% ispitanih učenika. Skoro 63,41% ispitanika probalo je alkohol, od kojih više od trećine pije 3 i više alkoholnih pića zaredom 23,18% dok je iskustvo pijanstva prijavilo 12,02% ispitivane dece.
Zaključak: Naši podaci ukazuju na to da je situacija sa COVID-19 uticala na društveni život mladih, kada su konzumiranje alkohola i cigareta u pitanju. 
Može se zaključiti da je neophodno sprovoditi preventivne programe u cilju smanjenja upotrebe duvana i alkohola kod adolescenata. Mladi, njihovi roditelji i drugi bitni ljudi iz njihovog okruženja, prosvetni radnici, društvena zajednica, mediji, treba da naglašavaju  štetnost alkohola i duvana.
EFL TEACHERS’ PERCEPTIONS TOWARDS USING AUTHENTIC MATERIALS IN TEACHING LISTENING / THÁI ĐỘ CỦA GIẢNG VIÊN TIẾNG ANH ĐỐI VỚI VIỆC SỬ DỤNG TÀI LIỆU THỰC TẾ TRONG VIỆC GIẢNG DẠY KỸ NĂNG NGHE
Authors: Quoc Pham Dinh , Trang Nguyen Thi Thuy
Published: March 2024

Apparently, teachers’ perceptions and practices play an important role in language teaching and learning, which has been recognized by Ellis (1999) and Krashen (1981). However, the purpose of the research is to find out if the review literature search has focused on this respect in teaching listening so far, especially in the Vietnamese context. The present study documents teachers’ perceptions and practices towards using authentic materials in teaching listening in the foreign language centers in Can Tho City. The researcher used multi-methods of data collection i.e. questionnaire observation and interview, in which 45 teachers got involved. The findings show that most teachers had positive perceptions about using authentic materials in teaching listening in terms of resources for using authentic materials, criteria of using authentic materials, learners’ levels and using authentic materials, Stages in the listening lesson of using authentic materials, benefits of using authentic materials, challenges of using authentic materials. The study also finds that factors such as teachers’ different teaching contexts, educational backgrounds, teaching experiences, genders, and ages did not affect their perceptions. Significantly, many mismatches were found between teachers’ perceptions and practices about teaching listening. The result of the study confirms that teachers’ perceptions were partly reflected in their practices. Considering these findings, some implications were made.
 

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EFFECTS OF EMPLOYEE DEVELOPMENT AND WELFARE ON PERFORMANCE: A CASE STUDY OF ACCRA TECHNICAL UNIVERSITY, GHANA
Authors: Annan Evelyn Dede Oboshie , Ashai Doreen Tsotsoo , Boatemaa Faustina Nana Yaa
Published: March 2024

Human resources are the most important resource of every organization. To get the best out of them, they need to be properly managed by providing them with the needed resources. Employee development and welfare are basically a higher form of motivation to prove their commitment. This study was designed to assess the effects of employee development and welfare on the performance of the staff of Accra Technical University, Ghana. A total of 100 respondents comprising 21 senior staff and 79 junior staff were used in the study and a questionnaire was used to gather data. Findings indicated that short courses, seminars, workshops, delegation, coaching, and participation are some of the employee development activities of Accra Technical University. Welfare packages include first aid equipment, sitting facility, medical facilities and leave travel concessions. Factors that generally affect employee development and welfare are limited opportunities, organizational culture, and the attitude of top management. Among the recommendations made was that management should have more organized and efficient development program opportunities for its employees to help retain them. Additionally, management should improve the welfare packages of employees.
 

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SORROW AND REMORSE IN ANNE SEXTON’S POETRY
Authors: Hammoud Faten
Published: March 2024

Readers and critics alike responded to Anne Sexton's confessional poetry in conflict during the 1950s and 60s. Because of the authentic way in which her poems delve into emotions, some critics had a positive opinion of her poetry. However, some critics contended that Sexton's writing was tainted by her emotions rather than being poetry in the traditional sense. The nature of emotion in poetry and its importance are assessed by the critics in each scenario. Emotions, in fact, secure the sense and meaning of the poetry in a sense-making manner. This essay argues that Sexton's use of emotion to convey her feelings about particular events is evident in her poetry. Through an analysis of her poetry, one can discern the ways in which her individual emotions shaped the overall structure of the poem as well as the shaping spirit and cognitive dimension of emotion. This essay examines the feelings of regret and grief found in Anne Sexton's poetry and shows how these feelings explain the things that happened in her life and give her poems meaning and logic. It makes the case that the emotion found in Sexton's poetry is based on assessments and judgments the woman has made about things that have happened in her life. Sexton considered these events and her feelings about them with awareness and intelligence.
 

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NAVIGATING DIGITAL MARKETING: EXAMINING SELF-ESCAPISM ATTITUDES AND ONLINE BUYING INTENTIONS IN SAUDI ARABIA
Authors: Alharthey Bandar Khalaf
Published: March 2024

Online shopping is a widely acknowledged phenomenon in the Kingdom of Saudi Arabia (KSA), with platforms like Noon and Amazon.sa serving as prominent destinations for millions of users. Driven by both utilitarian and hedonic motives, users in KSA actively engage in online shopping activities. While existing literature highlights the significance of self-escapism as a fundamental hedonic motivation, users' attitude towards online buying and purchasing behavior remain understudied. This study explores dimensions of users' self-escapism which includes self-suppression and self-expansion motivation in the context of online shopping in KSA and its direct and mediated effects on their attitude and buying behavior. The research is based on the collection of data from 219 users of noon.com and amazon.sa in KSA through an online survey. The findings of this study reveal that users' self-escapism motivation in online shopping engagement is a two-dimensional construct, encompassing self-suppression and self-expansion factors. This motivation directly influences customers' engagement with online shopping. The study identifies mediating roles of attitude toward online shopping intention during users' online buying experiences. This research provides valuable insights into the motivations of users who turn to online shopping as a means of self-regulation in the KSA context. Sellers can leverage these perceptions to create online shopping environments that cater to the self-escapism needs of users, thereby influencing and encouraging them to make online purchases.
 

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THE EFFECTIVENESS OF ECCENTRIC EXERCISE AND STATIC STRETCHING IN IMPROVING THE CALF MUSCLE FLEXIBILITY IN UNIVERSITY MALE STUDENTS - A COMPARATIVE STUDY
Authors: Rout Dwarikanath , Vikram Kumar , Tiwari Avinash , Mohanty Nihar Ranjan
Published: March 2024

Background: This study endeavoured to find the effectiveness of static stretching and eccentric training for the improvement of calf muscle flexibility in university students. Methodology: Forty university male students between the age group of 18-25 years volunteered to participate in the study. Anthropometric variables, i.e. height, weight, and Body Mass Index (BMI) measured. Result & Conclusion: Statistical analyses of data performed using the Statistical Package for the Social Sciences (SPSS) version 21.0. The level of significance was set at 0.05. The eccentric training group showed statistically significant improvements in active and passive calf muscle flexibility when compared to the static stretching group.

 

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