bluuebunny/crossref_metadata_2025 huggingface dataset:
A Z generáció turisztikai információkeresési szokásai a Covid–érában
Authors: Iványi Tamás , Veres István
Published: May 2022

A Covid–19 2019. évi megjelenése és gyors világméretű szétterjedése a hazai turizmus közel tízéves dinamikus növekedését törte meg. 2020-ban a világ valamenynyi országában jelentős korlátozásokat, járványügyi intézkedéseket hoztak, amely a turisztikai ipar kínálati és keresleti oldalát is jelentős kihívások elé állította. Tanulmányunk elsődlegesen a fogyasztói, keresleti oldalra fókuszál a turisztikai információgyűjtést segítő digitális technológiai alkalmazások vizsgálatán keresztül, valamint a pandémia okozta változásokat mutatja be a turisztikai döntéshozatal folyamatában. Számos digitális platform szerepe egyértelműen felértékelődött a járvány alatt, azonban a képet árnyalják a tanulmány primer kutatási részében bemutatott három fogyasztói csoport közötti jelentős eltérések az információgyűjtésben. Az eredmények rávilágítanak arra is, hogy számos fi atal igen tudatosan gyűjti az információkat az utazást megelőzően, azonban sokak számára még mindig nem ismertek és kevésbé fontosak az utóbbi években felértékelődött, utazási területre fókuszáló közösségi oldalak, platformok.
Territorialidades emergentes y sustento familiar de población étnica en territorios urbanos Dos estudios de caso en la ciudad de Pereira
Authors: Grueso Vanegas Clara Inés
Published: May 2022

El presente libro se deriva una investigación institucional desarrollada entre los años 2016 y 2017 por el grupo de investigación Territorio, Educación y Sociedad, adscrito a la Escuela de Ciencias Sociales, con la participación de los estudiantes vinculados al semillero de investigación Grupos Étnicos, Territorio y Ambiente del programa de la Licenciatura en Etnoeducación y Desarrollo Comunitario. La investigación fue aprobada mediante convocatoria realizada por la Vicerrectoría de Investigaciones, Innovación y Extensión de la Universidad Tecnológica de Pereira y se propuso «… identificar las territorialidades emergentes en relación con la consecución del sustento familiar en los reasentamientos poblacionales de la Ciudadela Salamanca y el barrio El Remanso de la ciudad de Pereira». Como parte del propósito institucional de contribuir a la investigación formativa de estudiantes de los programas de pregrado, se vincularon a este ejercicio académico dos trabajos de grado dirigidos por la investigadora principal y los cuales fueron realizados por las estudiantes Blanca Nathalia Arias Londoño, Jesús Mauricio Mena Machado, Erika Cristina Toro Marín y Natalia Andrea Medina Cardona.
Frequentist and Bayesian analysis methods for case series data and application to early outpatient COVID-19 treatment case series of high risk patients
Authors: Gkioulekas Eleftherios , McCullough Peter A , Zelenko Vladimir
Published: May 2022

When confronted with a public health emergency, significant innovative
treatment protocols can sometimes be discovered by medical doctors at
the front lines based on repurposed medications. We propose a very
simple hybrid statistical framework for analyzing the case series of
patients treated with such new protocols, that enables a comparison with
our prior knowledge of expected outcomes, in the absence of treatment.
The goal of the proposed methodology is not to provide a precise
measurement of treatment efficacy, but to establish the existence of
treatment efficacy,  in order to facilitate the binary decision of
whether the treatment protocol should be adopted  on an emergency basis.
The methodology consists of a frequentist component that compares a
treatment group against the  probability of an adverse outcome in the
absence of treatment, and calculates an efficacy threshold that has to
be exceeded by this  probability, in order to control the corresponding
$p$-value, and reject the null hypothesis. The  efficacy threshold is
further adjusted with a Bayesian technique, in order to also control the
false positive rate. A selection bias threshold is then calculated from
the efficacy threshold to control for random selection bias. Exceeding
the efficacy threshold establishes efficacy by the preponderance of
evidence, and exceeding the more demanding selection bias threshold
establishes efficacy by the clear and convincing evidentiary standard.
The combined techniques are applied to case series of high-risk COVID-19
outpatients, that were treated using the early Zelenko protocol and the
more enhanced McCullough protocol. The resulting efficacy thresholds are
then compared against our prior knowledge of mortality and
hospitalization rates of untreated high-risk COVID-19 patients, as
reported in the research literature.
Peripartum cardiomyopathy and Coronavirus Disease 2019 (COVID-19) associated cardiomyopathy: case series and review of literature
Authors: Dehghan Maryam , Fakhrolmobasheri Mohammad , Kawakita Tetsuya , Mazaheri-tehrani Sadegh , Rastegar Aref , Seresht Leila Mousavi
Published: May 2022

Purpose: Peripartum cardiomyopathy (PPCM) is a rare
complication of pregnancy manifesting with acute cardiac failure.
Coronavirus Disease 2019 (COVID-19) can be complicated by
cardiomyopathy, which can be difficult to differentiate from PPCM. The
aim of this publication is to investigate different outcomes of cases
with cardiomyopathy during pregnancy. Methods: Here, we report
4 peripartum cases with COVID-19 and acute cardiac failure due to
cardiomyopathy. Moreover, to find previous similar cases, a
comprehensive review on PPCM and COVID-19 associated cardiomyopathy was
conducted in PubMed, Scopus, Embase, and Google Scholar.
Results: Out of 4 cases we had, two cases deceased and one
became a candidate for heart transplant. Despite advanced diagnostic
approaches, differentiating COVID-19 associated cardiomyopathy from PPCM
was challenging. According to the literature review, 7 cases with
similar conditions were found. Conclusion: Pregnant women with
COVID-19 may develop acute cardiac failure associated with PPCM or
COVID-19 associated cardiomyopathy or both. This condition may be deadly
due to rapid disease progression, atypical manifestations, and limited
treatment options.
Peri-Coronary Sinus flutter: a unique form of atypical atrial flutter. A case report.
Authors: Ziakos A. , Greiss H. , Sezenias A. , Sause A.
Published: May 2022

The coronary sinus musculature connects to the right and the left
atrium, forming electrical interatrial bridges and can be a critical
part of various left atrial and biatrial flutter circuits. We herein
present a rare case of a macroreentrant tachycardia around the coronary
sinus using interatrial connections at its orifice and the inferolateral
left atrium and the adjacent left atrial myocardium.
Alveolar Dead Space Fraction is Not Associated with Early RV Systolic Dysfunction in Pediatric ARDS
Authors: Chilcote Daniel , Mercer-Rosa Laura , Wang Yan , kawut Steven , Berg Robert A. , Yehya Nadir , Himebauch Adam S.
Published: May 2022

Primary Hypothesis: We hypothesized that higher alveolar dead space
fraction (AVDSf) at PARDS onset would be associated with right
ventricular (RV) systolic dysfunction within the first 24 hours of
PARDS. Study Design and Methods: We performed a retrospective
single-center cohort study of PARDS patients with clinically obtained
echocardiograms within 24 hours. Primary exposure was AVDSf at PARDS
onset. Primary outcome was RV systolic dysfunction as defined by RV
global longitudinal strain (GLS) (> - 18%). Secondary
outcomes included pulmonary hypertension (PH) and RV systolic
dysfunction as defined by other echocardiogram parameters, and measures
of oxygenation. Unadjusted and adjusted logistic and linear regression
were used to investigate AVDSf associations with outcomes. Results:
Seventy-six patients were included: median age 6.2 years, 50% female,
and 66% with moderate or severe PARDS. Median AVDSf was 0.2 (IQR
0.1-0.3), 32% had RV dysfunction, and 24% had PH. Unadjusted and
adjusted logistic regression showed no association between AVDSf and RV
systolic dysfunction or PH by any echocardiographic measure. Unadjusted
and adjusted linear regression demonstrated the association of AVDSf
with both oxygenation index and PaO /FiO
. AVDSf did not discriminate RV dysfunction (AUROC for
RV GLS was 0.51, 95% CI 0.36-0.66). Conclusion: AVDSf at PARDS onset
was not associated with RV systolic dysfunction or PH within 24 hours
but was associated with metrics of hypoxemia and may be more reflective
of pulmonary causes of ventilation-perfusion mismatch. Future
investigations should focus on clarifying the clinical utility of AVDSf
in relation to existing metrics throughout the course of PARDS.
Design of capacitor-less LDO regulator with high reliability ESD Protection circuit using analog switch structure for 5 V applications
Authors: Kwon Sang wook , koo yong seo
Published: May 2022

This letter suggests to the LDO regulator with the high reliability ESD
protection circuit that achieves low peak voltage through analog switch
structure. The proposed LDO regulator has the function of detecting the
output voltage fluctuations depending on the load via an analog switch
structure and effectively controlling the peak voltage. The proposed ESD
protection circuit is placed on I / O and power lines to prevent the IC
circuit from being destroyed from the inevitable ESD phenomenon. It was
verified that the reliability of the IC can be improved through
effective current discharge due to ESD surge. The proposed LDO
regulator, implemented in a 0.18μm BCD process, achieves an undershoot
voltage of 25 mV and an overshoot voltage of 28 mV for a load current of
300 mA.
Bilateral vocal fold paresis and glottal bridge synechia in COVID-19
Authors: Tardue-Breiter Antonia , Glueck Anna , Dier Helga , Sprinzl Georg
Published: May 2022

Although COVID-19 is known to affect peripheral as well as cranial
nerves, there is a paucity of reports on vocal fold paresis in COVID-19,
bilateral vocal fold paresis (BVFP) in particular. We describe a case of
BVFP and glottal bridge synechia following COVID-19-pneumonia discussing
pathomechanisms and treatment options.
Reoccurence of Takotsubo Cardiomyopathy Induced by Osimertinib: Case Report
Authors: Fukuda Yuko , Kawa Yoshitaka , Nonaka Akiko , Shiotani Hideyuki
Published: May 2022

A patient with lung cancer was administrated osimertinib. She developed
symptomatic heart failure due to Takotsubo-cardiomyopathy (TC). As her
condition improved after discontinuing osimertinib, TC was thought to be
caused by osimertinib. Re-occurrence of TC was seen after
re-administraing half dose of osimernitib.
Diosgenin Inhibits Prostate Cancer Progression by Inducing UHRF1 Protein Degradation
Authors: Tang Rong , Peng Yuchong , Ding Liuyang , Liu Youhong , Yin Linglong , Fu Yongming , Deng Tanggang , Li Xiong
Published: May 2022

Background and Purpose: Aberrant overexpression of UHRF1 has been
reported in several cancer types and UHRF1 is regarded as a novel drug
target for cancer therapy. However, no UHRF1-targeted specific small
compound inhibitor has been registered in clinical trials. Experimental
Approach: Network pharmacology together with molecular docking were used
to screened a natural molecule bank for PCa treatment. The expression of
related protein or mRNA were evaluated by WB and RT-PCR. The
ubiquitination levels were assessed by WB. CCK8 assess was used to
measuring cells viability. Additionally, PCa cells cycle were analysed
by cytofluorimetry, genomic DNA methylation was assessed by Dot blot
analysis. Cellular senescence was assessed by Senescence-Associated
β-Galactosidase Staining Kit. DU145 cell xenograft models were used to
assess the in vivo effect of DSG inhibition. Key Results: Identified DSG
as a new natural compound specifically targeting UHRF1 protein
degradation through the ubiquitin-proteasome pathway, DSG-induced UHRF1
protein degradation reduced the level of genomic DNA methylation, and
re-activated the expression of such TSGs as p21, p16 and LXN, thereby
resulted in cell cycle arrest, cell senescence and reduced DU145
xenograft tumor growth. Altogether, clarified DSG anticancer mechanism
as an epigenetic regulatory drug for the treatment of PCa. Conclusions
and Implications: Our results first time identified DSG which extract
from natural plants specifically targeting UHRF1 protein. This vpresent
study provided a promising strategy to discover new molecule-targeted
drug from natural compounds. KEYWORDS: Traditional Chinese Medicine;
Prostate cancer; Diosgenin; DNA methylation; Tumor suppressor genes;
Post-COVID-19 chronic pulmonary aspergillosis in an immunocompetent woman with a history of pulmonary tuberculosis: a case report
Authors: Kuate Marius Paulin Ngouanom , Bongomin Felix
Published: May 2022

Previously treated pulmonary tuberculosis and Corona Virus Disease -2019
predispose to CPA and other pulmonary fungal diseases due to residual
lung damage. We report a case of CPA in a 63-years-old Cameroonian woman
with a history of PTB, 13 months after suffering from COVID-19 and
treated with itraconazole 100mg.
Understanding the relationship between dispersal and range size
Authors: Alzate Adriana , Onstein Renske
Published: May 2022

Understanding what drives the vast variability in species range size is
still an outstanding question. Among the several processes potentially
affecting species ranges, dispersal is one of the most prominent
hypothesized predictors. However, the theoretical expectation of a
positive dispersal-range size relationship has received mixed empirical
support. Here, we synthesized results from 84 studies to investigate in
which context dispersal is most important in driving species range size.
We found that dispersal traits – proxies for dispersal ability –
explain range sizes more often in temperate and subtropical regions than
in tropical regions, when considering multiple components of dispersal,
and when investigating a large number of species to capture dispersal
and range size variation. In plants, positive effects of dispersal on
range size were less often detected when examining broad taxonomic
levels. In animals, dispersal is more important for range size increase
in ectotherms than in endotherms. Our synthesis emphasizes the
importance of considering different aspects of the dispersal process
-departure, transfer, settlement-, niche aspects and evolutionary
components, like time for range expansion and past
geological-environmental dynamics. We therefore call for a more
integrative view of the dispersal process and its causal relationship
with range size.
HFE H63D mutation: why are you killing your patients?
Authors: Diamandis Dr. Carolina , Lazar Marius , Smith Lucas , Ivanova Olga , Seideman David , Kaufmann Marianne , Papadopoulou Sophia , Tudor Adrian , Feldman Jonathan , Schuster Georg , Honda Riku , Adams Jacob
Published: May 2022

Evidence-based medicine has shown for many years that homozygous
mutations of the HFE gene H63D are by no means negligible. Not only can
it cause, usually after a second hit, rather mild classical
hemochromatosis, but it can also cause numerous other disorders of iron
metabolism, such as hypotransferrinemia, changes in binding capacity,
and others. In addition, it may lead - among other symptoms - to damages
of the heart and the substantia nigra via a causal relationship that
remains to be investigated, most likely via a cascade dysfunction in
iron metabolism. The clinical facts are compelling. Any physician who
dismisses mutations of the HFE gene H63D as clinically irrelevant risks
the health and life of his patient. We report two patients with an HFE
H63D mutation who were treated almost too decades too late because of
outdated expertise.
Application of shape analysis to the assessment of geometrical properties of grains in the selected species of spring cereals
Authors: Borusiewicz Andrzej , Drożyner Paulina
Published: May 2022

The competition in many branches of industry including agriculture has grown as a result of Polish access to the European Union. It resulted in the intense research development in order to intensify production processes and improve the quality of the final product. One of the methods which might be helpful in this process is the shape analysis. This method makes it possible to measure selected properties of materials in a very precise way. The paper presents the possibilities of computer analysis in the research of grain geometrical features of 128 species of cereals. The program ImageJ was used. It enabled us to define surface, perimeter, width, height and circular projection of every caryopsis. Shape analysis also helps to define basic values of the tested features of caryopsis species. Significant differences between the shape of tested cereals species were indicated. However, significant differences between varieties of the same species were not found. Barley grain had the largest average surface while rye grain had the smallest one. Winter barley grain had the largest perimeter and spring wheat had the smallest one. Oat was characterized by the longest average length while spring wheat had the smallest one. Winter barley had the largest grain width and rye had the smallest one. Spring wheat grain is the most circular while oat grain is the less circular one. Taking into consideration the data mentioned above, one can use them in the production of equipment and machines used for seed planting, selection, segregation of cereal seeds both in agriculture as well as in agricultural and food processing industry.
Color transformation method that preserves the impression of texture in virtual makeover system
Authors: Kaczmarczyk Joanna , Pankiewicz Maciej
Published: May 2022

The algorithms of color transformation that preserves the impression of texture are used in virtual makeover systems, where maintaining the impression of unaltered texture is important in the process of transforming the color. The content of this paper covers the process of implementing the algorithm of digital picture color transformation with its main objective - minimizing its influence on the texture structure. The main idea of the presented algorithm is to determine the area in HSV space that consists of the original picture pixels and then, to move it towards the target color in such a way that every color is moved by the same vector, limited only by the fact that the transformation is not always possible. The analysis of the algorithm was conducted based on fragments of real face photographs. Its results were compared on the basis of measures estimated on the run length matrix and the co-occurrence matrix.
Bag of Words - Quality Issues of Near-Duplicate Image Retrieval
Authors: Paradowski Mariusz , Broda Bartosz , Durak Mariusz
Published: May 2022

This paper addresses the problem of large scale near-duplicate image retrieval. Issues related to visual words dictionary generation are discussed. A new spatial verification routine is proposed. It incorporates neighborhood consistency, term weighting and it is integrated into the Bhattacharyya coefficient. The proposed approach reaches almost 10\% higher retrieval quality, comparing to other recently reported state-of-the-art methods.
EBMBDT: Effective Block Matching Based Denoising Technique using dual tree complex wavelet transform
Authors: Selvi M.
Published: May 2022

In processing and investigation of digital image denoising of images is hence very important. In this paper, we propose a Hybrid de-noising technique by using Dual Tree Complex Wavelet Transform (DTCWT) and Block Matching Algorithm (BMA). DTCWT and BMA is a method to identify the noisy pixel information and remove the noise in the image. The noisy image is given as input at first. Then, bring together the comparable image blocks into the load. Afterwards Complex Wavelet Transform (CWT) is applied to each block in the group. The analytic filters are made use of by CWT, i.e. their real and imaginary parts from the Hilbert Transform (HT) pair, defending magnitude-phase representation, shift invariance, and no aliasing. After that, adaptive thresholding is applied to enhance the image in which the denoising result is visually far superior. The proposed method has been compared with our previous de-noising technique with Gaussian and salt-pepper noise. From the results, we can conclude that the proposed de-noising technique have shown better values in the performance analysis.
Stability of solution for Rao-Nakra sandwich beam model with Kelvin-Voigt damping and time delay
Authors: Cabanillas Victor , Raposo Carlos , Potenciano-Machado Leyter
Published: May 2022

This paper deals with stability of solution for a one-dimensional model of Rao?Nakra sandwich beam with Kelvin?Voigt damping and time delay given by ??1?1?????? ? ??1?1?????? ? ??(??? + ?? + ??????) ? ?????????? ? ??????????( ? , ?? ? ??) = 0, ??3?3?????? ? ??3?3?????? + ??(??? + ?? + ??????) ? ?????????? = 0, ????????? + ?????????????? ? ????(??? + ?? + ??????)?? ? ?????????? = 0. A sandwich beam is an engineering model that consists of three layers: two stiff outer layers, bottom and top faces, and a more compliant inner layer called ?core layer?. Rao?Nakra system consists of three layers and the assumption is that there is no slip at the interface between contacts. The top and bottom layers are wave equations for the longitudinal displacements under Euler?Bernoulli beam assumptions. The core layer is one equation that describes the transverse displacement under Timoshenko beam assumptions. By using the semigroup theory, the well-posedness is given by applying the Lumer?Phillips Theorem. Exponential stability is proved by employing the Gearhart-Huang-Pr?ss? Theorem.
Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes
Authors: D’Addio Francesca , Sabiu Gianmarco , Usuelli Vera , Assi Emma , Abdelsalam Ahmed , Maestroni Anna , Seelam Andy Joe , Ben Nasr Moufida , Loretelli Cristian , Mileto Davide , Rossi Giada , Pastore Ida , Montefusco Laura , Morpurgo Paola S. , Plebani Laura , Rossi Antonio , Chebat Enrica , Bolla Andrea M. , Lunati Maria Elena , Mameli Chiara , Macedoni Maddalena , Antinori Spinello , Rusconi Stefano , Gallieni Maurizio , Berra Cesare , Folli Franco , Galli Massimo , Gismondo Maria Rita , Zuccotti Gianvincenzo , Fiorina Paolo
Published: May 2022

Patients with type 1 diabetes (T1D) may develop severe outcomes during coronavirus disease 2019 (COVID-19), but their ability to generate an immune response against the SARS-CoV-2 mRNA vaccines remains to be established. We evaluated the safety, immunogenicity, and glycometabolic effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in patients with T1D. A total of 375 patients (326 with T1D and 49 subjects without diabetes) who received two doses of the SARS-CoV-2 mRNA vaccines (mRNA-1273, BNT162b2) between March and April 2021 at ASST Fatebenefratelli Sacco were included in this monocentric observational study. Local and systemic adverse events were reported in both groups after SARS-CoV-2 mRNA vaccination, without statistical differences between them. While both patients with T1D and subjects without diabetes exhibited a parallel increase in anti-SARS-CoV-2 spike titers after vaccination, the majority of patients with T1D (70% and 78%, respectively) did not show any increase in the SARS-CoV-2–specific cytotoxic response compared with the robust increase observed in all subjects without diabetes. A reduced secretion of the T-cell–related cytokines interleukin-2 and tumor necrosis factor-α in vaccinated patients with T1D was also observed. No glycometabolic alterations were evident in patients with T1D using continuous glucose monitoring during follow-up. Administration of the SARS-CoV-2 mRNA vaccine is associated with an impaired cellular SARS-CoV-2–specific cytotoxic immune response in patients with T1D.
Identification of Novel Disease-Relevant Genes and Pathways in the Pathogenesis of Type 1 Diabetes: A Potential Defect in Pancreatic Iron Homeostasis
Authors: Yip Linda , Alkhataybeh Reem , Taylor Cariel , Fuhlbrigge Rebecca , Fathman C. Garrison
Published: May 2022

Multiple pathways contribute to the pathophysiological development of type 1 diabetes (T1D), however, the exact mechanisms involved are unclear. We performed differential gene expression analysis in pancreatic islets of non-obese diabetic (NOD) mice versus age-matched congenic NOD.B10 controls to identify genes that may contribute to disease pathogenesis. Novel genes related to extracellular matrix development and glucagon and insulin signaling/secretion were changed in NOD mice during early inflammation. During “respective” insulitis, the expression of genes encoding multiple chemosensory olfactory receptors genes were upregulated, and during “destructive” insulitis, the expression of genes involved in antimicrobial defense and iron homeostasis were downregulated. Islet inflammation reduced the expression of Hamp that encodes hepcidin. Hepcidin is expressed in beta cells and serves as the key regulator of iron homeostasis. We showed that Hamp and hepcidin levels were lower, while iron levels were higher in the pancreas of 12-week old NOD versus NOD.B10 mice, suggesting that a loss of iron homeostasis may occur in the islets during the onset of “destructive” insulitis. Interestingly, we showed that the severity of NOD disease correlates with dietary iron intake. NOD mice maintained on low iron diets had a lower incidence of hyperglycemia while those maintained on high iron diets had an earlier onset and higher incidence of disease, suggesting that high iron exposure combined with a loss of pancreatic iron homeostasis may exacerbate NOD disease. This mechanism may explain the link seen between high iron exposure and the increased risk for T1D in humans. 
Immunogenicity and safety of SARS-CoV-2 mRNA vaccines in a cohort of patients with type 1 diabetes
Authors: D’Addio Francesca , Sabiu Gianmarco , Usuelli Vera , Assi Emma , Abdelsalam Ahmed , Maestroni Anna , Seelam Andy Joe , Nasr Moufida Ben , Loretelli Cristian , Mileto Davide , Rossi Giada , Pastore Ida , Montefusco Laura , Morpurgo Paola S. , Plebani Laura , Rossi Antonio , Chebat Enrica , Bolla Andrea M. , Lunati Elena , Mameli Chiara , Macedoni Maddalena , Antinori Spinello , Rusconi Stefano , Gallieni Maurizio , Berra Cesare , Folli Franco , Galli Massimo , Gismondo Maria Rita , Zuccotti Gian Vincenzo , Fiorina Paolo
Published: May 2022

Patients with type 1 diabetes (T1D) may develop severe outcomes during COVID-19 disease, but their ability to generate an immune response against the SARS-CoV-2 messenger RNA (mRNA) vaccines remains to be established. Here we evaluated the safety, immunogenicity and glycometabolic effects of the SARS-CoV-2 mRNA vaccines in patients with T1D. A total of 375 patients, 326 with T1D and 49 non-diabetics, who received two doses of the SARS-CoV-2 mRNA vaccines (mRNA-1273, BNT162b2) between March and April 2021 at the ASST FBF-Sacco Milan, Italy, were included in this monocentric observational study (NCT04905823). Local and systemic adverse events were reported in both groups after SARS-CoV-2 mRNA vaccination without statistical differences between them. While both T1D patients and non-diabetic subjects exhibited a parallel increase in anti-SARS-CoV-2S titers after vaccination, the vast majority of T1D patients (70% and 78% respectively) did not show any increase in the SARS-CoV-2-specific cytotoxic response as compared to the robust increase observed in all non-diabetic subjects. A reduced secretion of the T cell-related cytokines IL-2 and TNF-alpha in vaccinated patients with T1D was also observed. No glycometabolic alterations were evident in patients with T1D using continuous glucose monitoring during follow-up. Administration of the SARS-CoV-2 mRNA vaccine is associated with an impaired cellular SARS-CoV-2-specific cytotoxic immune response in T1D patients.  
Reliability of the Posterior Condylar Axis as an Alternative Reference for Femoral Rotation in Japanese Patients with Varus Knee Osteoarthritis Undergoing Total Knee Arthroplasty
Authors: Hattori Yosuke
Published: May 2022

Background: This study aimed to assess the reliability of the posterior condylar axis (PCA), the most widely used alternative reference for the surgical transepicondylar axis (sTEA), as a reference for appropriate femoral rotational alignment in total knee arthroplasty (TKA) by comparing variances with other alternative reference axes. Methods: A total of 305 knees in 233 Japanese patients who underwent TKA due to varus knee osteoarthritis were assessed in this study. Variances and relationships between alternative references were determined. Angles of alternative reference axes relative to the sTEA in the axial plane were measured using computer software based on computed tomography. Results: The PCA line was 3.0°±1.8° (range, -2.1° to 8.8°) internally rotated relative to the sTEA. No significant differences were observed in the PCA angle relative to the sTEA angle between males and females. The variance with respect to the sTEA was significantly smaller in the order of anatomical transepicondylar axis (aTEA), PCA, and antero-posterior axis (APA). The variance of the APA and that of the femoral anterior tangent line (FAT) did not significantly differ, while the variance of the FAT was significantly smaller than that of the trochlear anterior line (TAL). The proportion of outliers for PCA (>3° away from the average value) was 9.8%. The PCA was weakly correlated with the aTEA, APA, FAT, and TAL. Conclusions: In terms of variance with respect to the sTEA, the PCA was second to aTEA in reliability as an alternative reference axis, and was on average 3.0°±1.8° internally rotated relative to the sTEA. Our findings suggest that the PCA is a reliable and reproducibly identifiable alternative axis for accurately determining femoral rotational alignment in TKA.
Evaluating Provisioning Services in Betana Wetland Area, Belbari, Morang, Nepal
Authors: RA Mandal
Published: May 2022

The ecosystem services from the wetlands offer economic opportunities for beneficiaries as well as generate revenue that in turn be used for conservation of the wetlands but the research regarding this is very limited in Nepal. Thus, this research was objectively conducted to assess the value of provisioning ecosystem services in and around Betana wetland, Nepal. The primary data were collected organizing questionnaire survey with 65 beneficiary households, key informant interviews with 11 key experts, and direct observations in January 2020; whereas the secondary data were collected from the published and unpublished documents related to the wetland. Statistically, descriptive and inferential statistics were applied to analyze the collected data so, Friedmen test, Likert scale, multi-regression analysis, correlation analysis were performed. The result showed that, there are 6 major provisioning services of the Betana wetland, namely; (a) water for irrigation, (b) fish farming, (c) water for others purpose (domestic & livestock’s), (d) fodder, (e) wild food and (f ) medicinal plants. Amongst these services, the estimated highest rank was 4.8 of the water use for irrigation. It was found that a total 1121 households were using the Betana wetland to irrigate about 219 ha of land and farming the crops like maize, rice, wheat etc. The monetary value of these crops was approximately US$ 223,958.33 based on hedonic pricing. The second highest rank was 4.52 of fish farming and its monetary value was about US$ 100,000. Especially, the farmers keep Silver Carp ( Hypophthalmichthys molitrix ), Bighead Carp ( Aristichthys nobilis ) and Grass Carp ( Ctenopharyngodon idellus ) in and around the wetland. The other services used by local people were (a) wild vegetable and mushroom (about 723 households); (b) livestock farming (it’s worth approximately US $ 137,766; (c) grass and fodder (which monetary value worth about US $ 3,571.16). Statically, the correlation was evaluated between willingness to pay for the services and social variables. It revealed that the age group of the respondents showed the highest correlation between these services with R 2 (0.725) and followed by the household income having R 2 value 0.678 at 95% confidence level (P=0.022). This research, therefore, concluded that the provisional ecological services of the Betana wetland are useful source to uplift the economic condition of beneficiaries and hence this will be an important insight for the policy makers and authorities working in wetland conservation.
Biostimulant Potential of Organic and Inorganic Amendments to Alleviate the Drought Stress in Wheat Crop in Pakistan
Authors: SR Ahmad
Published: May 2022

Drought is one of the most harmful environmental factors that adversely affect the growth of economically important crops and global food security. Its prevalence is increasing worldwide as a result of global warming and about one-third of the world land area is prone to drought. Droughts are also common in Pakistan that affects the agriculture. Wheat is the most important cereal crop in all over the world, but in Pakistan its yield is much lower than other countries. So, under this scenario there is a need to develop environment friendly approaches to mitigate the effects of drought stress for sustainable agricultural productivity. Use of organic matter can enhance soil moisture holding capacity and allow penetration of plant roots to access soil moisture and nutrients for higher crop yield. So, it is important to keep soil organic matter at reasonable levels to preserve the healthy soil. Cow dung manure and press mud both are good source of organic matter that can enhance nutrients and water holding capacity of soil. Silicon application can also improve the plant resistance to water deficiency under drought. Hence, the combine application of organic and inorganic amendments may be considered a practical approach to stimulate the growth and biomass of wheat crop under drought stress.
Implementasi Literasi Budaya dan Kewargaan di Sekolah Dasar
Authors: Safitri Syelviana , Ramadan Zaka Hadikusuma
Published: May 2022

Literasi budaya dan kewargaan merupakan kemampuan individu dan masyarakat untuk bertindak atas lingkungan sosialnya sebagai bagian dari budaya dan negara. Meningkatnya arus teknologi informasi sangat memengaruhi minat baca siswa. Tujuan penelitian adalah untuk mengeksplorasi implementasi literasi budaya dan kewargaan di sekolah dasar. Penelitian ini tergolong kedalam penelitian kualitatif dengan pendekatan metode penelitian yang digunakan ialah metode inkuiri naturalistic. Subjek yang terlibat dalam penelitian ini yakni 1 kepala sekolah, 4 guru, 4 siswa, dan 4 orang tua. Pengumpulan data dilakukan menggunakan metode observasi dan wawancara, dengan instrumen penelitian berupa lembar wawancara. Setelah data terkumpul, kemudian dianalisis dengan pendekatan kualitatif. Hasil penelitian ini adalah sekolah dasar telah mengimplementasikan literasi budaya dan kewargaan sebesar 80% ditinjau dari aspek basis kelas, aspek budaya sekolah, dan basis masyarakat berupa kegiatan membaca 15 menit setiap hari, peminjaman buku di perpustakan, penanaman nilai-nilai karakter, terdapat fasilitas literasi sekolah serta tingkat keterlibatan tim fasilitator. Saran dalam penelitian ini, agar seluruh guru, orang tua, dan siswa lebih menekankan budaya membaca walaupun terkendala dengan kesibukan.
Buku Cerita Bergambar Guna Meningkatkan Keterampilan Membaca Muatan Pelajaran Bahasa Indonesia Siswa Kelas III SD
Authors: Paramita Gusti Ayu Putu Pradnya , Gede Agung Anak Agung , Abadi Ida Bagus Gede Surya
Published: May 2022

Minimnya ketersediaan media pembelajaran yang sesuai serta mampu meningkatkan minat membaca siswa, khususnya pada muatan Bahasa Indonesia. Jika hal tersebut dibiarkan, maka akan berdampak pada menurunnya keterampilan membaca siswa. Tujuan penelitian ini adalah menciptakan buku cerita bergambar pada keterampilan membaca muatan pelajaran bahasa Indonesia siswa kelas III SD. Jenis penelitian ini adalah penelitian pengembangan (RnD) dengan menggunakan model pengembangan ADDIE. Subjek dari penelitian ini terdiri dari 1 orang ahli isi, 1 orang ahli desain, 1 orang ahli media, 3 orang uji perorangan, 9 orang uji kelompok kecil. Metode pengumpulan data pada penelitian ini menggunakan kuesioner dengan instrumen pengumpulan data rating scale. Teknik analisis data pada penelitian ini menggunakan teknik deskriptif kuantitatif. Hasil pengujian validitas yang diperoleh berdasarkan penilaian subjek penelitian secara berurut sangat baik. Maka, media buku cerita layak digunakan pada siswa kelas III SD dan telah teruji mampu meningkatkan keterampilan membaca siswa pada muatan Bahasa Indonesia. Implikasi dari pengembangan ini secara empiris terbukti dengan adanya media buku cerita bergambar dapat menarik perhatian siswa, memotivasi siswa agar lebih aktif dalam membaca, serta menjadikan pembelajaran lebih bervariasi.
Variação da atividade elétrica entre o repouso e a máxima contração voluntária dos músculos masseteres em homens adultos
Authors: Feitosa Taylinne Santana , Silva Nathaly Santiago , Nascimento Gerlane Karla Bezerra Oliveira
Published: May 2022

Introdução: A eletromiografia de superfície (EMGs) é um exame objetivo, indolor, não invasivo e de fácil aplicação utilizado para avaliar as atividades elétricas de determinado músculo ou grupo muscular durante a máxima contração voluntária, repouso e dinâmica funcional. Objetivo: Comparar a variação do potencial elétrico dos músculos masseteres entre o repouso e máxima contração voluntária em indivíduos com faixas etárias diferentes. Método: A pesquisa foi aprovada em comitê de ética e executada na Clínica Escola do Departamento de Fonoaudiologia da Universidade Federal de Sergipe obedecendo aos rigores éticos e de biossegurança. A amostra foi composta por 26 adultos sem queixas orofaciais, sexo masculino e idade variando entre 26 e 42 anos, divididos em Grupo 1 e Grupo 2, os quais assinaram um termo de consentimento livre e esclarecido concordando com a participação na pesquisa. Os voluntários foram submetidos à avaliação eletromiográfica dos músculos masseteres durante o repouso e máxima contração voluntária. Resultados: Houve uma diminuição da atividade elétrica do masseter quando se comparou o G1 com o G2, porém não foi observada uma linearidade desse declínio ao analisar o universo estudado. Por isso, deve-se levar em consideração que o envelhecimento é um processo fisiológico particular de cada ser, sendo influenciado por múltiplos fatores intrínsecos e extrínsecos ao organismo. Observou-se, também, que no repouso nenhum indivíduo teve absolutamente 0 nos seus registros eletromiográficos, caracterizando um estado basal de atividade elétrica para garantia do tônus. Conclusão: Foi verificado que os voluntários com 30 anos ou mais apresentaram um declínio nos potenciais mioelétricos e, possivelmente, um déficit de força associado.
Percepção de idosos na promoção da saúde auditiva
Authors: Bernardo Graziela , Potgurski Dayane , Silva Daniela , Souza Janaina , Heidemann Ivonete , Arakawa-Belaunde Aline
Published: May 2022

Objetivo: analisar as reflexões acerca da saúde auditiva vivenciadas por idosos em Círculos de Cultura, na perspectiva da promoção da saúde. Método: estudo qualitativo, tipo ação participante, fundamentado no Itinerário de Pesquisa de Paulo Freire que consiste de três etapas: investigação temática, codificação e descodificação, e o desvelamento crítico. Foram realizados quatro Círculos de Cultura com 13 idosos participantes de uma Universidade Aberta da Terceira Idade de um município do sul do país. O desvelamento foi realizado com base na metodologia Freireana, que prevê o processo analítico. Resultados: Os participantes, por meio de debates e reflexões, expressaram por escrito e verbalmente suas percepções acerca da audição. Foram investigados 22 temas geradores que revelaram as percepções, as transformações, os medos, as dificuldades de aceitação e superação das dificuldades relacionadas à temática sobre a audição. Os participantes desvelaram interesse em realizar exames auditivos para monitorar suas habilidades auditivas. Conclusão: Os Círculos de Cultura realizados com idosos participantes desvelou a possibilidade de ampliar seus conhecimentos a respeito da saúde auditiva e contribuir para melhoria da sua qualidade de vida.
Eläkkeelle siirtyneiden taidetoimijuus
Authors: Laes Tuulikki , Rautiainen Pauli
Published: May 2022

Tarkastelemme artikkelissamme suomalaisten eläkkeensaajien taide- ja kulttuuriosallistumista ja osallisuutta hyvinvoinnin ja osallisuuden viitekehyksessä. Tutkimme, millaisena eläkeläisten taidetoimijuus näyttäytyy vanhuuseläkesiirtymässä sekä miten taidetoimijuuden aktiivisuus tai passiivisuus suhteutuu nykyisiin käsityksiin vanhuuden ikäkauteen kuuluvasta merkityksellisestä toiminnasta. Aineistona on eläkevakuutusyhtiö Ilmarisen asiakkaille toteutettu kysely (N=510), jossa selvitettiin vastaajien taide- ja kulttuuriosallistumisen tapoja sekä arvioita omasta hyvinvoinnistaan. Kyselyyn vastanneet jakautuivat neljään taidetoimijuusprofiiliin. Sosioekonomisilla tekijöillä ei ollut tilastollisesti merkitsevää yhteyttä taidetoimijuuden asteeseen. Sen sijaan vastauksissa korostui kokemus taiteiden ja kulttuurin merkityksestä omalle hyvinvoinnille taide- ja kulttuuriosallistumista selittävänä tekijänä. Hyödynnämme artikkelissamme myös kyselyä syventäviä, taiteisiin ja kulttuuriin passiivisesti suhtautuneiden vastaajien haastatteluja. Havaintojemme perusteella ehdotamme ja perustelemme toimenpiteitä taidetoimijuuden vahvistamiseksi työelämästä eläkkeelle siirtymisen vaiheessa.
Art agency in retirement transition
This article examines participation in the arts and culture among Finnish pensioners in the framework of wellbeing. We study the emergence of art agency in the retirement transition and how it relates to current conceptions of the roles and meaningful participation of the ageing population. The data consists of a survey for the clients of the pension insurance company Ilmarinen (N = 510), which investigated the ways of participation in the arts and culture and the respondents’ assessment of their own well-being. In our analysis, respondents are divided into four art agency profiles. Socioeconomic factors had no statistically significant association with the degree of art agency. Instead, the experienced significance of the arts and culture for one's own well-being was highlighted in the responses as an explanatory factor for participation in the arts and culture. Based on our findings, we propose and justify measures to strengthen art agency in the retirement transition.
PERAN GURU DAN ORANG TUA DALAM MENINGKATKAN MOTIVASI BELAJAR SISWA PADA PEMBELAJARAN DARING DI SD NEGERI KARANGTOWO KABUPATEN DEMAK
Authors: Tauqifa Ayunita Hisbadina , Rahmawati Intan , Saputra Henry Januar
Published: May 2022

Abstract:The Role of the teacher and parents in increasing student learning motivation in online learning at SD Negeri Karangtowo, Demak Regency. The purpose of this study was to find out how the role of teachers and parents in increasing student motivation and the results of student learning motivation in online learning at SD Negeri Karangtowo, Demak Regency. This type of research is a descriptive qualitative method. The sample in this study were 29 students of class VB. Data collection techniques used in this study were observation, interviews, documentation and questionnaires. The results of this study indicate that the teacher's role in motivating student learning includes the teacher as a demonstrator, the teacher as a class manager, the teacher as a mediator, the teacher as a facilitator, the teacher as an evaluator, and the teacher as a motivator. Meanwhile, the role of parents in motivating student learning includes parents as mentors or educators, parents as facilitators, and parents as motivators. And the results of the average student learning motivation showed 4% of students who said yes while 2% of students who said no. This the role of teacher and parents affect student learning motivation. Keywords: Teachers, Parents, Learning Motivation, Online Learning  Abstrak: Peran Guru dan Orang Tua dalam Meningkatkan Motivasi Belajar Siswa pada Pembelajaran Daring di SD Negeri Karangtowo Kabupaten Demak. Tujuan penelitian ini untuk mengetahui bagaimana peran guru dan orang tua dalam meningkatkan motivasi belajar siswa dan hasil motivasi belajar siswapada pembelajaran daring di SD Negeri Karangtowo Kabupaten Demak. Jenis penelitian ini adalah metode kualitatif deskriptif. Sample dalam penelitian ini adalah 29 siswa kelas VB. Teknik pengumpulan data yang digunakan dalam penelitian ini berupa observasi, wawancara, dokumentasi dan angket. Hasil penelitian ini menunjukkan bahwa peran guru dalam memotivasi belajar siswa meliputi guru sebagai demonstrator, guru sebagai pengelola kelas, guru sebagai mediator, guru sebagai fasilitator, guru sebagai evaluator, dan guru sebagai motivator. Sedangkan peran orang tua dalam memotivasi belajar siswa meliputi orang tua sebagai pembimbing atau pendidik, orang tua sebagai fasilitator, orang tua sebagai motivator. Dan hasil rata-rata motivasi belajar siswa menunjukkan 4% siswa yang menyatakan ya sedangkan 2% siswa yang menyatakan tidak. Dengan demikian peran guru dan orang tua mempengaruhi motivasi belajar siswa.Kata Kunci: Guru, Orang Tua, Motivasi Belajar, Pembelajaran Daring
ANALISIS IMPLEMENTASI PROGRAM PENDIDIKAN ANAK BERKEBUTUHAN KHUSUS DI SDLB NEGERI PRABUMULIH
Authors: Putri Annisa , Jayanti Jayanti , Fakhrudin Ali
Published: May 2022

Abstract:. Education is a very important need for every human being, the state has an obligation to provide the right to education without exception, including those who have differences in abilities (disabled). The purpose of this research is to analyze the implementation of the education program for children with special needs (ABK), this study uses descriptive qualitative methods, data collection uses observation, interviews and documentation techniques, from the results of research conducted at SDLB Negeri Prabumulih, there are several types of children with special needs. With special needs (ABK) which have different classifications, the teacher conducts an assessment every semester to identify children with special needs (ABK). This school uses the 2013 curriculum and a special curriculum when needed, the learning process in the classroom is not much different from other public schools, it's just that sometimes teachers have to be more patient in dealing with students with disabilities (different or abnormal abilities).Keywords: Analysis, Learning Poses, ABK Abstrak: Pendidikan merupakan kebutuhan yang sangat penting bagi setiap manusia negara memiliki kewajiban untuk memberikan hak pendidikan tanpa terkecuali termasuk mereka yang memiliki perbedaan dalam kemampuan (difabel). Tujuan dilakukan penelitian ini yaitu untuk menganalisis implementasi program pendidikan anak berkebutuhan khusus (ABK), penelitian ini menggunakan metode kualitatif deskriptif, pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi, dari hasil penelitian yang di lakukan di SDLB Negeri prabumulih, ada beberapa jenis anak berkebutuhan khusus (ABK) yang memiliki klasifikasi yang berbeda, guru melakukan assesment setiap semester untuk mengidentifikasi anak berkebutuhan khusus (ABK). Sekolah ini menggunakan kurikulum 2013 dan kurikulum khusus saat di perlukan, dalam proses pembelajaran di kelas tidak berbeda jauh dengan sekolah umum lainnya, hanya saja terkadang guru harus lebih sabar dalam menghadapi siswa difabel (kemampuan yang berbeda atau abnormal)..Kata Kunci : Analisis, Poses pembelajaran, ABK