bluuebunny/crossref_metadata_2025 huggingface dataset:
Computed tomography for evaluating right ventricle and pulmonary artery in pediatric tetralogy of Fallot: correlation with post-operative pulmonary regurgitation
Authors: Gao Yue , Yang Zhi-gang , Shi Ke , Diao Kai-yue , Xu Hua-yan , Guo Ying-kun
Published: May 2018

Pulmonary regurgitation (PR) is the most common complication after tetralogy of Fallot (TOF) surgical repair, and long-term PR might result in cardiovascular events. The aim of this study was to assess the influence of pre-operative right ventricle (RV) and pulmonary artery (PA) parameters assessed by dual-source computed tomography on post-operative PR. A total of 41 TOF patients who underwent trans-valve surgical repair were retrospectively recruited. The RV and PA parameters evaluated by pre-operative DSCT were compared between the PR and non-PR groups. Our result revealed that the PA parameters (McGoon ratio, Nakata index, and LPA diameter) and RV parameters (RV length diameter and RV short diameter) all showed significant differences between the two groups (all p < 0.05). There was a significant correlation between PR and LPA diameter (r = 0.361), McGoon ratio (r = 0.413), and Nakata index (r = 0.482). Receiver operating characteristic analysis also revealed a moderate sensitivity and specificity of LPA (66.33%; 82.60%), McGoon ratio (83.33%, 56.52%), and Nakata index (83.33%; 60.87%) for predicting the occurrence of PR. This study indicated that these pre-operative indices calculated by DSCT are associated with post-operative PR and that these pre-operative PA and RV parameters may serve as novel predictors of the risk of PR.
Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions
Authors: Silvas Tania V. , Hou Shurong , Myint Wazo , Nalivaika Ellen , Somasundaran Mohan , Kelch Brian A. , Matsuo Hiroshi , Kurt Yilmaz Nese , Schiffer Celia A.
Published: May 2018

The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing a first line of defense against many exogenous and endogenous retroviruses. However, the ability of these proteins to deaminate deoxycytidines in ssDNA makes A3s a double-edged sword. When overexpressed, A3s can mutate endogenous genomic DNA resulting in a variety of cancers. Although the sequence context for mutating DNA varies among A3s, the mechanism for substrate sequence specificity is not well understood. To characterize substrate specificity of A3A, a systematic approach was used to quantify the affinity for substrate as a function of sequence context, length, secondary structure, and solution pH. We identified the A3A ssDNA binding motif as (T/C)TC(A/G), which correlated with enzymatic activity. We also validated that A3A binds RNA in a sequence specific manner. A3A bound tighter to substrate binding motif within a hairpin loop compared to linear oligonucleotide, suggesting A3A affinity is modulated by substrate structure. Based on these findings and previously published A3A–ssDNA co-crystal structures, we propose a new model with intra-DNA interactions for the molecular mechanism underlying A3A sequence preference. Overall, the sequence and structural preferences identified for A3A leads to a new paradigm for identifying A3A’s involvement in mutation of endogenous or exogenous DNA.
Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography
Authors: Fukuda Shinichi , Fujita Akari , Kasaragod Deepa , Beheregaray Simone , Ueno Yuta , Yasuno Yoshiaki , Oshika Tetsuro
Published: May 2018

Polarization-sensitive optical coherence tomography (PS-OCT) allows the recording of depth-resolved polarimetric measurements. It has been reported that phase retardation and local birefringence images can noninvasively detect fibrotic area in blebs after glaucoma surgery. Evaluation of scar fibrosis in blebs is important not only for predicting bleb function, but also for planning revision trabeculectomy. Herein, we characterize the intensity, phase retardation, and local birefringence images of blebs using PS-OCT. A total of 85 blebs from 85 patients who had undergone trabeculectomy were examined. Both phase retardation and local birefringence images detected fibrotic changes in blebs after glaucoma surgery. Phase retardation images detected slight fibrotic change during the early stage after surgery, whereas local birefringence images showed localized fibrotic tissue. There are two main patterns of local birefringence image changes in blebs: plate-like birefringence changes and diffuse changes. The area of plate-like birefringence change was significantly larger in poorly functioning blebs and is thus correlated with bleb function. These data suggest that the plate-like fibrotic change evaluation by PS-OCT may be useful not only for noninvasive evaluation of fibrotic scar tissue in blebs, but also for developing strategies for revision trabeculectomy.
Immunoprofiling of Chlamydia trachomatis using whole-proteome microarrays generated by on-chip in situ expression
Authors: Hufnagel Katrin , Lueong Smiths , Willhauck-Fleckenstein Martina , Hotz-Wagenblatt Agnes , Miao Beiping , Bauer Andrea , Michel Angelika , Butt Julia , Pawlita Michael , Hoheisel Jörg D. , Waterboer Tim
Published: May 2018

Using Chlamydia trachomatis (Ct) as a complex model organism, we describe a method to generate bacterial whole-proteome microarrays using cell-free, on-chip protein expression. Expression constructs were generated by two successive PCRs directly from bacterial genomic DNA. Bacterial proteins expressed on microarrays display antigenic epitopes, thereby providing an efficient method for immunoprofiling of patients and allowing de novo identification of disease-related serum antibodies. Through comparison of antibody reactivity patterns, we newly identified antigens recognized by known Ct-seropositive samples, and antigens reacting only with samples from cervical cancer (CxCa) patients. Large-scale validation experiments using high-throughput suspension bead array serology confirmed their significance as markers for either general Ct infection or CxCa, supporting an association of Ct infection with CxCa. In conclusion, we introduce a method for generation of fast and efficient proteome immunoassays which can be easily adapted for other microorganisms in all areas of infection research.
Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
Authors: Zhou Ang , Taylor Amy E. , Karhunen Ville , Zhan Yiqiang , Rovio Suvi P. , Lahti Jari , Sjögren Per , Byberg Liisa , Lyall Donald M. , Auvinen Juha , Lehtimäki Terho , Kähönen Mika , Hutri-Kähönen Nina , Perälä Mia Maria , Michaëlsson Karl , Mahajan Anubha , Lind Lars , Power Chris , Eriksson Johan G. , Raitakari Olli T. , Hägg Sara , Pedersen Nancy L. , Veijola Juha , Järvelin Marjo-Riitta , Munafò Marcus R. , Ingelsson Erik , Llewellyn David J. , Hyppönen Elina
Published: May 2018

Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.
Structure and crystallography of foliated and chalk shell microstructures of the oyster Magallana: the same materials grown under different conditions
Authors: Checa Antonio G. , Harper Elizabeth M. , González-Segura Alicia
Published: May 2018

Oyster shells are mainly composed of layers of foliated microstructure and lenses of chalk, a highly porous, apparently poorly organized and mechanically weak material. We performed a structural and crystallographic study of both materials, paying attention to the transitions between them. The morphology and crystallography of the laths comprising both microstructures are similar. The main differences were, in general, crystallographic orientation and texture. Whereas the foliated microstructure has a moderate sheet texture, with a defined 001 maximum, the chalk has a much weaker sheet texture, with a defined 011 maximum. This is striking because of the much more disorganized aspect of the chalk. We hypothesize that part of the unanticipated order is inherited from the foliated microstructure by means of, possibly,$${\boldsymbol{\{}}{\bf{01}}\bar{{\bf{1}}}{\bf{8}}{\boldsymbol{\}}}$${011¯8}twinning. Growth line distribution suggests that during chalk formation, the mantle separates from the previous shell several times faster than for the foliated material. A shortage of structural material causes the chalk to become highly porous and allows crystals to reorient at a high angle to the mantle surface, with which they continue to keep contact. In conclusion, both materials are structurally similar and the differences in orientation and aspect simply result from differences in growth conditions.
A paradox of epidemics between the state and parameter spaces
Authors: Liu Hengcong , Zheng Muhua , Liu Zonghua
Published: May 2018

It is recently revealed from amounts of real data of recurrent epidemics that there is a phenomenon of hysteresis loop in the state space. To understand it, an indirect investigation from the parameter space has been given to qualitatively explain its mechanism but a more convincing study to quantitatively explain the phenomenon directly from the state space is still missing. We here study this phenomenon directly from the state space and find that there is a positive correlation between the size of outbreak and the size of hysteresis loop, implying that the hysteresis is a nature feature of epidemic outbreak in real case. Moreover, we surprisingly find a paradox on the dependence of the size of hysteresis loop on the two parameters of the infectious rate increment and the transient time, i.e. contradictory behaviors between the two spaces, when the evolutionary time of epidemics is long enough. That is, with the increase of the infectious rate increment, the size of hysteresis loop will decrease in the state space but increase in the parameter space. While with the increase of the transient time, the size of hysteresis loop will increase in the state space but decrease in the parameter space. Furthermore, we find that this paradox will disappear when the evolutionary time of epidemics is limited in a fixed period. Some theoretical analysis are presented to both the paradox and other numerical results.
Physical mechanism of spring and early summer drought over North America associated with the boreal warming
Authors: Choi Woosuk , Kim Kwang-Yul
Published: May 2018

Drought during the early vegetation growing season (spring through early summer) is a severe natural hazard in the large cropland over North America. Given the recent increasing severity of climate change manifested as surface warming, there has been a growing interest in how warming affects drought and the prospect of drought. Here we show the impact of boreal warming on the spring and early summer drought over North America using Cyclostationary Empirical Orthogonal Function analysis. Northern Hemispheric warming, the leading mode of the surface air temperature variability, has led to a decrease in precipitation, evaporation and moisture transport over the central plain of North America. From a quantitative assessment of atmospheric water budget, precipitation has decreased more than evaporation and moisture transport, resulting in increased (decreased) moisture in the lower troposphere (land surface). Despite the increased moisture content, relative humidity has decreased due to the increased saturation specific humidity arising from the lower-tropospheric warming. The anomaly patterns of the soil moisture and Palmer Drought Severity Index resemble that of the anomalous relative humidity. Results of the present study suggest a credible insight that drought in the main cropland will intensify if the anthropogenic warming continues, exacerbating vulnerability of drought.
Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE−/− mice
Authors: Hsiung Sabrina , Knutsson Anki , Vallejo Jenifer , Dunér Pontus , Heinonen Suvi E. , Jönsson-Rylander Ann-Cathrine , Bengtsson Eva , Nilsson Jan , Hultgårdh-Nilsson Anna
Published: May 2018

The mechanisms responsible for macrovascular complications in diabetes remain to be fully understood. Recent studies have identified impaired vascular repair as a possible cause of plaque vulnerability in diabetes. This notion is supported by observations of a reduced content of fibrous proteins and smooth muscle cell mitogens in carotid endarterectomy from diabetic patients along with findings of decreased circulating levels of endothelial progenitor cells. In the present study we used a diabetic mouse model to characterize how hyperglycemia affects arterial repair responses. We induced atherosclerotic plaque formation in ApoE-deficient (ApoE−/−) and heterozygous glucokinase knockout ApoE-deficient mice (ApoE−/− GK+/−) mice with a shear stress-modifying cast. There were no differences in cholesterol or triglyceride levels between the ApoE−/− and ApoE−/− GK+/− mice. Hyperglycemia did not affect the size of the formed atherosclerotic plaques, and no effects were seen on activation of cell proliferation, smooth muscle cell content or on the expression and localization of collagen, elastin and several other extracellular matrix proteins. The present study demonstrates that hyperglycemia per se has no significant effects on tissue repair processes in injured mouse carotid arteries, suggesting that other mechanisms are involved in diabetic plaque vulnerability.
A truncating mutation in EPOR leads to hypo-responsiveness to erythropoietin with normal haemoglobin
Authors: Oskarsson Gudjon R. , Kristjansson Ragnar P. , Lee Amy L. , Sveinbjornsson Gardar , Magnusson Magnus K. , Ivarsdottir Erna V. , Benonisdottir Stefania , Oddsson Asmundur , Davidsson Olafur B. , Saemundsdottir Jona , Halldorsson Gisli H. , Arthur Joseph , Arnadottir Gudny A. , Masson Gisli , Jensson Brynjar O. , Holm Hilma , Olafsson Isleifur , Onundarson Pall T. , Gudbjartsson Daniel F. , Norddahl Gudmundur L. , Thorsteinsdottir Unnur , Sulem Patrick , Stefansson Kari
Published: May 2018

The cytokine erythropoietin (EPO), signalling through the EPO receptor (EPO-R), is essential for the formation of red blood cells. We performed a genome-wide association study (GWAS) testing 32.5 million sequence variants for association with serum EPO levels in a set of 4187 individuals. We detect an association between a rare and well imputed stop-gained variant rs370865377[A] (p.Gln82Ter) in EPOR, carried by 1 in 550 Icelanders, and increased serum EPO levels (MAF = 0.09%, Effect = 1.47 SD, P = 3.3 × 10−7). We validated these findings by measuring serum EPO levels in 34 additional pairs of carriers and matched controls and found carriers to have 3.23-fold higher EPO levels than controls (P = 1.7 × 10−6; Pcombined = 1.6 × 10−11). In contrast to previously reported EPOR mutations, p.Gln82Ter does not associate with haemoglobin levels (Effect = −0.045 SD, P = 0.32, N = 273,160), probably due to a compensatory EPO upregulation in response to EPO-R hypo-responsiveness.
Uniform resolution of compact identifiers for biomedical data
Authors: Wimalaratne Sarala M. , Juty Nick , Kunze John , Janée Greg , McMurry Julie A. , Beard Niall , Jimenez Rafael , Grethe Jeffrey S. , Hermjakob Henning , Martone Maryann E. , Clark Tim
Published: May 2018

Most biomedical data repositories issue locally-unique accessions numbers, but do not provide globally unique, machine-resolvable, persistent identifiers for their datasets, as required by publishers wishing to implement data citation in accordance with widely accepted principles. Local accessions may however be prefixed with a namespace identifier, providing global uniqueness. Such “compact identifiers” have been widely used in biomedical informatics to support global resource identification with local identifier assignment. We report here on our project to provide robust support for machine-resolvable, persistent compact identifiers in biomedical data citation, by harmonizing the Identifiers.org and N2T.net (Name-To-Thing) meta-resolvers and extending their capabilities. Identifiers.org services hosted at the European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL-EBI), and N2T.net services hosted at the California Digital Library (CDL), can now resolve any given identifier from over 600 source databases to its original source on the Web, using a common registry of prefix-based redirection rules. We believe these services will be of significant help to publishers and others implementing persistent, machine-resolvable citation of research data.
Computational screening of high-performance optoelectronic materials using OptB88vdW and TB-mBJ formalisms
Authors: Choudhary Kamal , Zhang Qin , Reid Andrew C.E. , Chowdhury Sugata , Van Nguyen Nhan , Trautt Zachary , Newrock Marcus W. , Congo Faical Yannick , Tavazza Francesca
Published: May 2018

We perform high-throughput density functional theory (DFT) calculations for optoelectronic properties (electronic bandgap and frequency dependent dielectric function) using the OptB88vdW functional (OPT) and the Tran-Blaha modified Becke Johnson potential (MBJ). This data is distributed publicly through JARVIS-DFT database. We used this data to evaluate the differences between these two formalisms and quantify their accuracy, comparing to experimental data whenever applicable. At present, we have 17,805 OPT and 7,358 MBJ bandgaps and dielectric functions. MBJ is found to predict better bandgaps and dielectric functions than OPT, so it can be used to improve the well-known bandgap problem of DFT in a relatively inexpensive way. The peak positions in dielectric functions obtained with OPT and MBJ are in comparable agreement with experiments. The data is available on our websites http://www.ctcms.nist.gov/~knc6/JVASP.html and https://jarvis.nist.gov.
Time series dataset of fish assemblages near thermal discharges at nuclear power plants in northern Taiwan
Authors: Chen Hungyen , Chen Ching-Yi , Shao Kwang-Tsao
Published: May 2018

Long-term time series datasets with consistent sampling methods are rather rare, especially the ones of non-target coastal fishes. Here we described a long-term time series dataset of fish collected by trammel net fish sampling and observed by an underwater diving visual census near the thermal discharges at two nuclear power plants on the northern coast of Taiwan. Both experimental and control stations of these two investigations were monitored four times per year in the surrounding seas at both plants from 2000 to 2017. The underwater visual census mainly monitored reef fish assemblages and trammel net samples monitored pelagic or demersal fishes above the muddy/sandy bottom. In total, 508 samples containing 203,863 individuals from 347 taxa were recorded in both investigations at both plants. These data can be used by ecologists and fishery biologists interested in the elucidation of the temporal patterns of species abundance and composition.
Photodegradation kinetics of lisdexamfetamine dimesylate and structure elucidation of its degradation products by LC-ESI-QTOF
Authors: Carlos Graciela , Segalin Jéferson , Jank Louise , Comiran Eloisa , Herbstrith de Oliveira Marcella , Froehlich Pedro Eduardo
Published: May 2018

Herein, we investigate the photodegradation of lisdexamfetamine (LDX) in an aqueous solution.
EU-7 zeolite: a synthetic BIK type zeolite with high hydrothermal stability
Authors: De Prins Michiel , Verheyen Elke , Kerkhofs Stef , Hoffmann Andreas , Vanbutsele Gina , Sree Sreeprasanth Pulinthanathu , Radhakrishnan Sambhu , Van Tendeloo Leen , Breynaert Eric , Kirschhock Christine E. A. , Schütze Frank-Walter , Martens Johan A.
Published: May 2018

EU-7 is identified as BIK topology and proves stable to withstand steaming at 900 °C relevant to DeNOx catalysis.
Screening effects on the field enhancement factor of zigzag graphene nanoribbon arrays: a first-principles study
Authors: Hu Han , Lin Tzu-Chien , Leung Tsan-Chuen , Su Wan-Sheng
Published: May 2018

The field screening effect on the electronic and field-emission properties of zigzag graphene nanoribbons (ZGNRs) has been studied using first-principles calculations.
Ab initio calculations on the ground and excited electronic states of neutral and charged palladium monoxide, PdO0,+,−
Authors: Almeida Nuno M. S. , Ariyarathna Isuru R. , Miliordos Evangelos
Published: May 2018

Multi-reference configuration interaction and coupled cluster calculations were carried out for the ground and several low-lying excited electronic states for PdO, PdO+, and PdO−. The photoelectron spectrum peaks of PdO were assigned.
Engineering graphene and TMDs based van der Waals heterostructures for photovoltaic and photoelectrochemical solar energy conversion
Authors: Li Changli , Cao Qi , Wang Faze , Xiao Yequan , Li Yanbo , Delaunay Jean-Jacques , Zhu Hongwei
Published: May 2018

This review provides a systematic overview of the integration, surface, and interfacial engineering of 2D/3D and 2D/2D homo/heterojunctions for PV and PEC applications.
Novel antimony(iii) hydroxamic acid complexes as potential anti-leishmanial agents
Authors: Keogan D. M. , Oliveira S. S. C. , Sangenito L. S. , Branquinha M. H. , Jagoo R. D. , Twamley B. , Santos A. L. S. , Griffith D. M.
Published: May 2018

The synthesis, characterisation and anti-leishmanial activity of novel Sb(iii) hydroxamato and Sb(iii) hydroxamato/hydroximato complexes are reported.
Magnesium and zinc complexes bearing NNO-tridentate ketiminate ligands: synthesis, structures and catalysis in the ring-opening polymerization of lactides
Authors: Huang Yong , Kou Xin , Duan Yu-Lai , Ding Fei-Fei , Yin Yi-Fan , Wang Wei , Yang Ying
Published: May 2018

Magnesium and zinc complexes bearing pyrazoline-derived ketiminate ligands, [(L1–3)2M2(μ-OBn)2] and [M(L)2] proceed through the “coordination–insertion” mechanism in the ROP of lactides.
A bi-metallic MOF catalyst via sensitive detection & adsorption of Fe3+ ions for size-selective reaction prompting
Authors: Li Yang , Chang Ziling , Huang Fangmin , Wu Pengyan , Chu Huacong , Wang Jian
Published: May 2018

Novel MOF adsorbed Fe3+ presents the first example of a bi-metallic Lewis-acid catalyst for the cyanosilylation reaction in a size-selective fashion.
Cluster-to-cluster transformation among Au6, Au8 and Au11 nanoclusters
Authors: Ren Xiuqing , Fu Junhong , Lin Xinzhang , Fu Xuemei , Yan Jinghui , Wu Ren'an , Liu Chao , Huang Jiahui
Published: May 2018

This manuscript demonstrates the cluster-to-cluster transformations among three gold nanoclusters, which were all monitored and corroborated using UV-Vis spectroscopy and ESI-MS.
A porphyrin covalent organic framework cathode for flexible Zn–air batteries
Authors: Li Bo-Quan , Zhang Shu-Yuan , Wang Bin , Xia Zi-Jing , Tang Cheng , Zhang Qiang
Published: May 2018

A porphyrin covalent organic framework cathode is fabricated under multiscale materials regulation for flexible Zn–air batteries.
Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents
Authors: Aikman Brech , de Almeida Andreia , Meier-Menches Samuel M. , Casini Angela
Published: May 2018

Metal ions and complexes can interfere with the transcellular water flow but also with the cellular transport of glycerol and hydrogen peroxide,viainhibition of the ubiquitous aquaporin channels.
A metalloligand appended with benzimidazole rings: tetranuclear [CoZn3] and [CoCd3] complexes and their catalytic applications
Authors: Pandey Saurabh , Bansal Deepak , Gupta Rajeev
Published: May 2018

A novel Co3+-based metalloligand, offering appended benzimidazole rings, has been utilized for the synthesis of catalytically active tetranuclear [CoZn3] and [CoCd3] heterometallic coordination complexes.
ChemoselectiveN-tert-butyloxycarbonylation of amines in glycerol
Authors: Ingale Ajit P. , More Vishal K. , Gangarde Uddhav S. , Shinde Sandeep V.
Published: May 2018

The operational simplicity, cleaner reaction, rapid reaction convergence, functional group tolerance, excellent yield, high selectivity, catalyst-free feature and solvent recyclability are the distinct advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.
Y1-receptor–ligand-functionalized ultrasmall upconversion nanoparticles for tumor-targeted trimodality imaging and photodynamic therapy with low toxicity
Authors: Yu Zhangsen , Xia Yuanzhi , Xing Jie , Li Zihou , Zhen Jianjun , Jin Yinhua , Tian Yuchen , Liu Chuang , Jiang Zhenqi , Li Juan , Wu Aiguo
Published: May 2018

We design and synthesize an ultrasmall and low toxicity MNPs(MC540)/DSPE-PEG-NPY nanocomposite with the multifunctions of targeted trimodality imaging and PDT.
Polymorphism of Ag29(BDT)12(TPP)43− cluster: interactions of secondary ligands and their effect on solid state luminescence
Authors: Nag Abhijit , Chakraborty Papri , Bodiuzzaman Mohammad , Ahuja Tripti , Antharjanam Sudhadevi , Pradeep Thalappil
Published: May 2018

We present the first example of polymorphism (cubic & trigonal) in single crystals of an atomically precise monolayer protected cluster, Ag29(BDT)12(TPP)43−.
Mixed carboxylic–sulfonic anhydride in reaction with imines: a straightforward route to water-soluble β-lactams via a Staudinger-type reaction
Authors: Bakulina Olga , Dar'in Dmitry , Krasavin Mikhail
Published: May 2018

The first example of employing a mixed carboxylic–sulfonic anhydride in reaction with imines is reported. It gave β-lactams, presumably, via a formal [2 + 2] cycloaddition (a Staudinger-type reaction).
Chelation-assisted de-aryloxylative amination of 2-aryloxy quinolines: a new synthetic route to a key fragment of a bioactive PRMT5 inhibitor
Authors: Gupta Aniket , Kumar Jogendra , Bhadra Sukalyan
Published: May 2018

A copper catalysed regiospecific de-aryloxylative amination of O- or N-chelating group-functionalized 2-aryloxyquinolines constitutes a new route to access a PRMT5 inhibitor.
Janus molecules: large second-order nonlinear optical performance, good temporal stability, excellent thermal stability and spherical structure with optimized dendrimer structure
Authors: Chen Pengyu , Zhang Huanyu , Han Mengmeng , Cheng Ziyao , Peng Qian , Li Qianqian , Li Zhen
Published: May 2018

A Janus molecule J2 containing five FTC moieties exhibited good thermal stability, excellent electro-optic performance and good temporal stability.
Strong, tough and mechanically self-recoverable poly(vinyl alcohol)/alginate dual-physical double-network hydrogels with large cross-link density contrast
Authors: Li Xuefeng , Shu Mengmeng , Li Han , Gao Xiang , Long Shijun , Hu Tao , Wu Chonggang
Published: May 2018

Intermediate compositions enable synergised, strong-and-tough dual-physical double-network hydrogels of dispersion-induced rigid, ionic alginate-networks interlocking with global ductile, hydrogen-bonded poly(vinyl alcohol)-network.
Flexible C–Mo2C fiber film with self-fused junctions as a long cyclability anode material for sodium-ion battery
Authors: Zhang Wenjie , Guo Zeyu , Liang Qinghua , Lv Ruitao , Shen Wanci , Kang Feiyu , Weng Yuqing , Huang Zheng-Hong
Published: May 2018

Fiber junctions were fused by introducing MoO2, that eliminates the contact resistance at fiber junctions, and significantly improves the cyclability.
Designable core–shell graphite particles for thermally conductive and electrically insulating polymer composites
Authors: Hirahara Takashi
Published: May 2018

Core–shell graphite particles were successfully prepared via a mechanical mixing process. The thermally conductive and electrically insulating properties were designable for injection mouldable polymer composites.
Effects of calcium ion and pH on the adsorption/regeneration process by activated carbon permeable reactive barriers
Authors: Li Shengpin , Li Wenpeng , Chen Honghan , Liu Fei , Jin Song , Yin Xiulan , Zheng Yuejun , Liu Boyang
Published: May 2018

Activated carbon (AC) is widely used in groundwater remediation, more specifically, for the activated carbon permeable barriers (AC-PRBs).
Enhancement of dielectric constant of polyimide by doping with modified silicon dioxide@titanium carbide nanoparticles
Authors: Zhang Tong , Han Bao-Jun , Yu Juan , Wang Xiao-Dong , Huang Pei
Published: May 2018

PI/SiO2@TiC composites with enhanced dielectric constant are synthesized by hydrolysis of TEOS into microspheres forming a thin SiO2layer on the TiC surface followed by mechanical blending of ODA and PMDA.
Fully solution-induced high performance indium oxide thin film transistors with ZrOx high-k gate dielectrics
Authors: Zhu Li , He Gang , Lv Jianguo , Fortunato Elvira , Martins Rodrigo
Published: May 2018

Solution based deposition has been recently considered as a viable option for low-cost flexible electronics.
Modeling and prediction of methanol air release from bleached chemi-thermo mechanical pulp board
Authors: Zhang Yu , Chai Xin-Sheng , Huang Liulian , Chen Lihui , Hu Hui-Chao , Tian Ying-Xin
Published: May 2018

This paper reports on the modeling, prediction and evaluation approaches of methanol release from bleached chemi-thermo mechanical pulp (BCTMP) board during storage.
Superlattice-like structure and enhanced ferroelectric properties of intergrowth Aurivillius oxides
Authors: Yang He , Chen Zezhi , Peng Ranran , Huang Haoliang , Fu Zhengping , Zhai Xiaofang , Lu Yalin
Published: May 2018

Aurivillius oxides with an intergrowth structures have been receiving increasing interest because of their special structures and potential outstanding ferroelectric properties.
Graphene-based surface heater for de-icing applications
Authors: Karim Nazmul , Zhang Minglonghai , Afroj Shaila , Koncherry Vivek , Potluri Prasad , Novoselov Kostya S.
Published: May 2018

We report a scalable process of making highly conductive graphene-based glass fibre rovings and their integration into a vacuum infused epoxy–glass fabric composite. We then demonstrate the potential use of as prepared composites for de-icing applications.
Hierarchical nano zeolite-Y hydrocracking composite fibers with highly efficient hydrocracking capability
Authors: Anis Shaheen Fatima , Singaravel Gnanapragasam , Hashaikeh Raed
Published: May 2018

Nano zeolite fibers have superior conversions and catalytic stability compared to the micro counterpart.
Role of a polymeric component in the phase separation of ternary fluid mixtures: a dissipative particle dynamics study
Authors: Singh Amrita , Chakraborti Anirban , Singh Awaneesh
Published: May 2018

We explored the effect of polymeric fluid on coarsening morphology of phase separating ternary (ABC) mixtures by varying polymer concentration, length, and stiffness.
Tuning thin-film bijels with applied external electric fields
Authors: Carmack Joseph M. , Millett Paul C.
Published: May 2018

Electric-field alignment of particle-stabilized emulsions within thin-film geometries enables through-thickness morphologies, revealed with mesoscopic computer simulations.
Toward charge extraction in all-inorganic perovskite solar cells by interfacial engineering
Authors: Ding Jie , Duan Jialong , Guo Chenyang , Tang Qunwei
Published: May 2018

CuInS2/ZnS QDs with tunable bandgaps were applied at the CsPbBr3/carbon interface for improved hole extraction and reduced electron–hole recombination. A PCE of as high as 8.42% was achieved for QDs tailored all-inorganic PSC in comparison with 6.01% for the pristine device.
Engineering onion-like nanoporous CuCo2O4 hollow spheres derived from bimetal–organic frameworks for high-performance asymmetric supercapacitors
Authors: Ensafi Ali A. , Moosavifard Seyyed Ebrahim , Rezaei B. , Kaverlavani Saeid Kamari
Published: May 2018

An asymmetric supercapacitor fabricated using onion-like nanoporous CuCo2O4 hollow spheres exhibits an energy density of 48.75 W h kg−1 and a power density of 37.5 kW kg−1, which can compete with Ni–MH batteries.
Fully edible biofuel cells
Authors: Jeerapan Itthipon , Ciui Bianca , Martin Ian , Cristea Cecilia , Sandulescu Robert , Wang Joseph
Published: May 2018

This article describes the first example of edible energy harvesting biofuel cells, based solely on highly biocompatible and ingestible food materials.
Probing narrow-line Seyfert 1 galaxies in the southern hemisphere
Authors: Chen S. , Berton M. , La Mura G. , Congiu E. , Cracco V. , Foschini L. , Fan J. H. , Ciroi S. , Rafanelli P. , Bastieri D.
Published: May 2018

We present a new accurate catalog of narrow-line Seyfert 1 galaxies (NLS1s) in the southern hemisphere from the Six-degree Field Galaxy Survey (6dFGS) final data release, which is currently the most extensive spectroscopic survey available in the southern sky whose database has not yet been systematically explored. We classified 167 sources as NLS1s based on their optical spectral properties. We derived flux-calibrated spectra for the first time that the 6dFGS does not provide. By analyzing these spectra, we obtained strong correlations between the monochromatic luminosity at 5100 Å and the luminosities of Hβ and [O III]λ5007 lines. The central black hole mass and the Eddington ratio have average values of 8.6 × 106M⊙ and 0.96 LEdd respectively, which are typical values for NLS1s. In the sample, 23 (13.8%) NLS1s were detected at radio frequencies, and 12 (7.0%) of them are radio-loud. Our results confirmed that radio-loud sources tend to have higher redshift, a more massive black hole, and higher radio and optical luminosities than radio-quiet sources.
The st-bond polytope on series-parallel graphs
Authors: Grappe Roland , Lacroix Mathieu
Published: May 2018

The st-bond polytope of a graph is the convex hull of the incidence vectors of its st-bonds, where an st-bond is a minimal st-cut. In this paper, we provide a linear description of the st-bond polytope on series-parallel graphs. We also show that the st-bond polytope is the intersection of the st-cut dominant and the bond polytope.
Undecidability and hardness in mixed-integer nonlinear programming
Authors: Liberti Leo
Published: May 2018

We survey two aspects of mixed-integer nonlinear programming which have attracted less attention (so far) than solution methods, solvers and applications: namely, whether the class of these problems can be solved algorithmically, and, for the subclasses which can, whether they are hard to solve. We start by reviewing the problem of representing a solution, which is linked to the correct abstract computational model to consider. We then cast some traditional logic results in the light of mixed-integer nonlinear programming, and come to the conclusion that it is not a solvable class: instead, its formal sentences belong to two different theories, one of which is decidable while the other is not. Lastly, we give a tutorial on computational complexity and survey some interesting hardness results in nonconvex quadratic and nonlinear programming.
Prophylactic clip closure may reduce the risk of delayed bleeding after colorectal endoscopic submucosal dissection
Authors: Ogiyama Hideharu , Tsutsui Shusaku , Murayama Yoko , Maeda Shingo , Satake Shin , Nasu Ayaka , Umeda Daisuke , Miura Yoshio , Tominaga Kouhei , Horiki Masashi , Sanomura Tamana , Imanaka Kazuho , Iishi Hiroyasu
Published: May 2018

Background and study aims Endoscopic submucosal dissection (ESD) has a high en bloc resection rate and is widely performed for large superficial colorectal tumors, but delayed bleeding remains one of the most common complications of colorectal ESD. The aim of the present study was to evaluate the clinical efficacy of prophylactic clip closure of mucosal defects for the prevention of delayed bleeding after colorectal ESD.

Patients and methods We enrolled consecutive patients with colorectal lesions between January 2012 and May 2017 in this retrospective study. In the early part of this period, post-ESD mucosal defects were not closed (non-closure group); however, from January 2014, post-ESD mucosal defects were prophylactically closed with clips when possible (closure group). The main outcome measured was delayed bleeding. Variables were analyzed using the chi-squared test, Fisher’s exact test, or Student’s t-test.

Results Of 156 lesions analyzed, 61 were in the non-closure group and 95 in the closure group. Overall, delayed bleeding occurred in 5 cases (3.2 %). The delayed bleeding rate was 0 % (0/95) in the closure group and 8.2 % (5/61) in the non-closure group (P = 0.008). The mean procedure time for closure was 10.4 ± 4.6 min (range 3 – 26 min).

Conclusions We demonstrated that prophylactic clip closure of mucosal defects might reduce the risk of delayed bleeding after colorectal ESD.
Transoral Incisionless fundoplication for reflux after peroral endoscopic myotomy: a crucial addition to our arsenal
Authors: Tyberg Amy , Choi Anthony , Gaidhane Monica , Kahaleh Michel
Published: May 2018

Introduction Increased esophageal acid exposure is seen in a large percentage of patients with achalasia who undergo peroral endoscopic myotomy (POEM). Endoscopic transoral fundoplication (TIF) is a novel endoscopic technique for the management of patients with chronic gastroesophageal reflux (GERD). We present the first case series evaluating the role of TIF post-POEM.

Methods Consecutive patients 18 years or older from our academic institution who underwent a POEM procedure and subsequently underwent TIF for symptomatic reflux or regurgitation between December 2014 and June 2017 were included. The primary outcome was discontinuation of proton-pump inhibitor (PPI) use and healing of esophagitis (when initially present) on post-procedure esophagogastroduodenoscopy (EGD). Technical success was defined as successful completion of the endoscopic fundoplication. Adverse events (AEs) were recorded for all patients.

Results Five patients were included (60 % male, average age 55 ± 14 years). Technical success was achieved in 100 % of patients. Discontinuation of PPI use was achieved in 5/5 patients (100 %). Three patients had esophagitis pre-procedure and all were noted to have resolution of inflammation on post-procedure EGD. No adverse events were noted. Mean follow-up time was 27 months (range 5 – 34 months).

Conclusion TIF post-POEM appears feasible, safe, and efficacious in improving symptoms and esophagitis, decreasing long-term risks of acid exposure, and decreasing risks of long-term PPI use in patients post-POEM in this small cohort of patients. Larger studies are needed to confirm these initial findings.
Size of colorectal polyps determines time taken to remove them endoscopically
Authors: Kang Heechan , Thoufeeq Mo
Published: May 2018

Background an study aims Polypectomy and endoscopic mucosal resection (EMR) are effective and safe ways of removing polyps from the colon at endoscopy. Guidelines exist for advising the time allocation for diagnostic endoscopy but not for polypectomy and EMR. The aim of this study was to identify if time allocated for polypectomy and EMR at planned therapeutic lists in our endoscopy unit is sufficient for procedures to be carried out. We also wanted to identify factors that might be associated with procedures taking longer than the allocated time and to identify factors that might predict duration of these procedures.

Patients and methods A retrospective case study of planned 100 lower gastrointestinal EMR and polypectomy procedures at colonoscopy and sigmoidoscopy was performed and analyzed with quantitative analysis.

Results The mean actual procedural time (APT) for 100 procedures was 52 minutes and the mean allocated time (AT) was 43.05 minutes. Hence the mean APT was 9 minutes longer than the mean AT. Factors that were significantly associated with procedures taking longer than the allocated time were patient age (P = 0.029) and polyp size (P = 0.005). Factors that significant changed the actual procedure time were patient age (P = 0.018), morphology (P = 0.002) and polyp size (P < 0.001). Procedures involving flat and lateral spreading tumor (LST) type polyps took longer than the protruding ones. On multivariate analysis, polyp size was the only factor that associated with actual procedure time. Number of polyps, quality of bowel preparation, and distance of polyp from insertion did significantly change procedure duration.

Conclusion Factors that significantly contribute to duration of polypectomy and EMR at lower gastrointestinal endoscopy include patient age and polyp size and morphology on univariate analysis, with polyp size being the factor with a significant association on multivariate analysis. We recommend that endoscopy units take these factors into consideration locally when allocating time for these procedures to be safe and effective.
Needle fracture during endoscopic ultrasound-guided fine needle aspiration using a needle with a side hole
Authors: Sasaki Takashi , Kanata Ryo , Sasahira Naoki
Published: May 2018

Background and study aims Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is widely performed to obtain pathological evidence from several parts of the body. Major complications of EUS-FNA are bleeding, pancreatitis, and abdominal pain. Needle fracture is a rare complication of EUS-FNA and only a few relevant reports are available. Here, we report a case of needle fracture during EUS-FNA using a needle with a side hole. A 61-year-old man underwent EUS-FNA of the uncinate process of the pancreas to confirm malignancy. A 20-gauge needle with a side hole was used to puncture the mass from the first part of the duodenum. The needle fracture occurred at the side hole during the third passage, and the fragment remained in the pancreas. Fortunately, the patient did not exhibit any symptoms due to the needle fragment. This case indicates that repeated puncture using the same needle with a side hole might increase risk of needle fracture during EUS-FNA. It is important to inform clinicians about the potential risk of needle fracture, particularly given the increasing number of EUS-FNAs being performed.
Topische Kortikosteroide und nicht steroidale Antiphlogistika zur Behandlung der nicht infektiösen Uveitis
Authors: Doycheva Deshka , Deuter Christoph , Grajewski Rafael
Published: May 2018

Topische Kortikosteroide sind effektive entzündungshemmende Medikamente in der Therapie der anterioren Uveitis. Die intraokulare Effektivität der topischen Steroide ist überwiegend durch ihre Penetrationsfähigkeit ins Auge limitiert. Lipophile Präparate wie Dexamethason oder Prednisolonacetat penetrieren besser in die Vorderkammer als hydrophile. Prednisolonacetat 1% ist das Mittel der Wahl in der Behandlung von Patienten mit anteriorer Uveitis. Loteprednol und Fluorometholon besitzen eine schwächere antientzündliche Wirkung, beeinflussen aber weniger den Augeninnendruck und sind deswegen hilfreich bei Patienten mit Steroidresponse. Die antientzündliche Therapie mit lokalen Steroiden muss individuell angepasst werden in Abhängigkeit von Verlauf und Schweregrad der Uveitis. Die häufigsten unerwünschten Wirkungen der lokalen Kortisontherapie sind das steroidinduzierte Glaukom und die Katarakt. Nicht steroidale Antiphlogistika hemmen das Enzym Zyklooxygenase, das für die Bildung proinflammatorischer Prostaglandine zuständig ist. Sie haben eine ergänzende Rolle bei der Behandlung und Vorbeugung postoperativer Reizzustände nach Kataraktoperation. Eine therapeutische Rolle in der Behandlung der Uveitis und des zystoiden Makulaödems sekundär nach Uveitis konnte bisher nicht etabliert werden.
Colonic stent versus emergency surgery as treatment of malignant colonic obstruction in the palliative setting: a systematic review and meta-analysis
Authors: Ribeiro Igor , Bernardo Wanderley , Martins Bruno , de Moura Diogo , Baba Elisa , Josino Iatagan , Miyajima Nelson , Coronel Cordero Martin , Visconti Thiago , Ide Edson , Sakai Paulo , de Moura Eduardo
Published: May 2018

Background and study aims Colorectal cancer (CRC) is the third most common malignancy and the third leading cause of cancer death worldwide. Malignant colonic obstruction (MCO) due to CRC occurs in 8 % to 29 % of patients.The aim of this study was to perform a systematic review and meta-analysis of RCTs comparing colonic SEMS versus emergency surgery (ES) for MCO in palliative patients. This was the first systematic review that included only randomized controlled trials in the palliative setting.

Methods A literature search was performed according to the PRISMA method using online databases with no restriction regarding idiom or year of publication. Data were extracted by two authors according to a predefined data extraction form. Primary outcomes were: mean survival, 30-day adverse events, 30-day mortality and length of hospital stay. Stoma formation, length of stay on intensive care unit (ICU), technical success and clinical success were recorded for secondary outcomes. Technical success (TS) was defined as successful stent placement across the stricture and its deployment. Clinical success (CS) was defined as adequate bowel decompression within 48 h of stent insertion without need for re-intervention.

Results We analyzed data from four RCT studies totaling 125 patients. The 30-day mortality was 6.3 % for SEMS-treated patients and 6.4 % for ES-treated patients, with no difference between groups (RD: – 0.00, 95 % CI [–0.10, 0.10], I2: 0 %). Mean survival was 279 days for SEMS and 244 days for ES, with no significant difference between groups (RD: 20.14, 95 % CI: [–42.92, 83.21], I2: 44 %). Clinical success was 96 % in the ES group and 86.1 % in the SEMS group (RD: – 0.13, 95 % CI [–0.23, – 0.02], I2: 51 %). Permanent stoma rate was 84 % in the ES group and 14.3 % in the SEMS group (RR: 0.19, 95 % CI: [0.11, 0.33], I2: 28 %). Length of hospital stay was shorter in SEMS group (RD: – 5.16, 95 % CI: [–6.71, – 3.61], I2: 56 %). There was no significant difference between groups regarding adverse events (RD 0.18, 95 % CI: [–0.19, 0.54;]) neither regarding ICU stay. (RD: – 0.01, 95 % CI: [–0.08, 0.05], I2: 7 %). The most common stent-related complication was perforation (42.8 % of all AE).

Conclusion Mortality, mean survival, length of stay in the ICU and early complications of both methods were similar. SEMS may be an alternative to surgery with the advantage of early hospital discharge and lower risk of permanent stoma.