bluuebunny/crossref_metadata_2025 huggingface dataset:
Influencia del marketing de atracción en el posicionamiento en los clientes de Cineplanet Santa Clara (Ate) en 2019
Authors:   , Garcia Javier Francis Elizabeth
Published: March 2023

La presente investigación tuvo como finalidad medir la influencia del marketing de atracción en el posicionamiento en los clientes de Cineplanet, en la zona de Santa Clara (distrito de ATE), ubicado dentro de Lima Metropolitana, Perú. Teóricamente el estudio utilizó el marketing de atracción en relación a la percepción de los clientes de esta empresa y tuvo como objetivo la fidelización de sus clientes actuales y nuevos, respondió a la exigencia de los nativos digitales (jóvenes y adultos). Los avances del marketing digital implicaron cambios en las estrategias de atracción de los clientes, lo cual implico migración a plataformas virtuales en las cuales la interacción con los usuarios permitió y genero un valor diferencial para estos. La metodología fue correlacional y se aplicaron 384 encuestas a los clientes, con el propósito de poder conocer el grado de interacción que tiene con la empresa, reconocer el servicio al cliente que ofrece a través de su nivel de satisfacción, marketing de contenido y estrategia de promoción. Esta información recolectada junto con los antecedentes, sirvieron para demostrar que el marketing de atracción es fundamental para una empresa, por lo que tiene gran impacto en los consumidores, si se aplica de manera correcta.
Factores asociados a la depresión en adultos mayores con enfermedad de Parkinson tratados en un taller de Parkinson del servicio de geriatría del Centro Médico Naval en 2018-2019
Authors:   , Flores Pérez Yosselyn Gabriela , Oliva Canal Joseline Marysabel
Published: March 2023

La depresión es un trastorno no motor de la Enfermedad de Parkinson (EP), la cual influye en el desarrollo y su consecuente empeoramiento clínico además de afectar el bienestar biopsicosocial del adulto mayor con EP. Objetivo: Detectar los componentes asociados a depresión en la población geriátrica con EP. Material y métodos: Se efectuó un análisis detallado en base a la revisión de 55 historias clínicas de pacientes con Parkinson mediante un sistema no probabilístico utilizando criterios de inclusión y exclusión planteados en el presente trabajo. Resultados: se observó que el 29.09% de la muestra de pacientes con Parkinson presentó depresión, asimismo de este grupo se halló que en su mayoría tienen entre 73 a 81 años, son del sexo masculino y tienen sobrepeso ello en cuanto a los factores sociodemográficos; y en la parte clínica se aclara que en su mayoría presentaron comorbilidades, polifarmacia, dependencia total. Conclusión: De acuerdo a los hallazgos encontrados en el presente estudio se considera la identificación temprana de los componentes sociodemográficos y clínicos en pacientes con depresión y EP con el fin de obtener un diagnóstico precoz y adecuado tratamiento para optimizar el bienestar del paciente.
Asociación entre el nivel de multidrogorresistencia de Acinetobacter baumannii y la unidad de aislamiento en el Hospital Nacional Arzobispo Loayza (perídodo 2011-2019)
Authors:   , Barrientos Yong Rodrigo Samuel , Hinojosa Salas Bryan Andrei
Published: March 2023

Introducción: Acinetobacter baumannii es una bacteria de gran relevancia clínica como patógeno oportunista. El incremento de la resistencia antibiótica de A.baumannii ocasiona una problemática importante en los hospitales a nivel mundial. El objetivo principal del presente estudio es evaluar la evolución de la resistencia antimicrobiana de A.baumannii según su unidad de aislamiento en el hospital Nacional Arzobispo Loayza (período 2011-2019) así como su patrón de estacionalidad. Material y métodos: Se realizó un diseño de tipo, analítico, retrospectivo para determinar la asociación entre el nivel de multidrogoresistencia de A. baumannii y la unidad de aislamiento en el Hospital Nacional Arzobispo Loayza en el período 2011 - 2019. Se realizó una revisión de los resultados de los cultivos positivos de A. baumannii con información completa de antibiogramas, así como el servicio y fecha de procedencia del aislamiento. Las muestras se procesaron en el Servicio de Microbiología del mismo hospital, donde se realiza el cultivo en agares selectivos o BACTEC, para su identificación y caracterización del perfil sensibilidad a antimicrobianos mediante equipos semiautomáticos Vitek. Se realizó análisis bivariado entre los niveles de multidrogoresistencia con las covariables de interés utilizando la prueba de chi-cuadrado, finalmente se realizó un análisis multivariado de modelo lineal generalizado (GLM) de familia Poisson y link log de varianzas robustas, se reportaron razones de prevalencia crudas y ajustadas. El análisis de datos se realizó tabulando todos los aislados de A.baumannii obtenidos en el periodo de estudio que se encontraran debidamente identificados con fecha, lugar de aislamiento y tipo de muestra. Así mismo tomando en cuenta la resistencia indicada en los antibiogramas para la clasificación de la resistencia Antibiótica.
Factores asociados a la producción científica de los docentes de la carrera de medicina humana de una universidad privada de Lima durante la pandemia de la COVID-19
Authors:   , Ayala Colqui Ysmael Jesús
Published: March 2023

Introducción: La pandemia de la Covid-19 ha afectado la producción científica de las universidades. Se desconoce las causas de este último. De acuerdo con esto, el objetivo de la investigación es estudiar los factores asociados a la producción científica de los docentes en una universidad privada de Lima durante la pandemia. Materiales y métodos: Estudio transversal y analítico, de enfoque cuantitativo. Se incluyó a los docentes de la carrera de Medicina Humana. La búsqueda de las publicaciones (variable dependiente) se realizó en Scopus y Google Scholar. Se usó la técnica de la revisión documental. Resultados. En las regresiones logísticas los hallazgos fueron los siguientes: en los tres modelos existe una convergencia respecto a la importancia de las horas de investigación; asimismo, en ellas el grado académico fue significativo, especialmente el poseer el grado de doctor en los tres modelos con valores imputados. En las regresiones gamma se confirma que las horas dedicadas a la investigación son un determinante del número de publicaciones, Asimismo, se encontró que la variable género resulta relevante en la medida que existe una brecha donde las mujeres son las que presentan menor número de publicaciones. Discusión. Dado que los principales factores son el grado académico, el género y las horas de investigación, se confirma, para los dos primeros factores, la tendencia observada en otras investigaciones; con el tercer elemento se añade un punto a considerar en estos estudios, dado que es una variable poco considerada en la bibliografía académica sobre el tema.
Artificial Intelligence based Optimized Resource Allocation using Predictive Analysis in a Virtual Environment
Authors: B Sahana , Dinesh Diksha , N Deekshith K , Sru A V , Deshpande Abhay , Priyadarshi Rahul , Nath Vijay
Published: March 2023

In a virtual environment, load balancing is the best method of assigning a collection of tasks through a range of resources, in order to make the total output more efficient. Load balancers not only improve efficiency but also ensure system stability. Resource allocation in a virtual environment in this article is accomplished by using Amazon Web Services (AWS) and machine learning techniques. Round Robin resource allocation algorithm is used by HAProxy to perform Load Balancing responsibilities. The virtual servers created through Amazon Elastic Compute Cloud (EC2), all have the same characteristics, such as load bearing capacity and reaction time. One of the EC2 instances created is configured to host the HAProxy. The load bearing potential of HAProxy is inversely proportional to the execution time, ensuring faster processing of the incoming requests. HAProxy, as the load balancer, optimizes resource allocation and provides flexibility in contrast to a standard application load balancer. The logs created by the instances help predict future load on the servers, by applying the ARIMA time-series forecasting model. A Mean Squared Error of 3.28 is obtained, justifying the accuracy of the prediction.
Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture
Authors: Liesz Arthur , Cao Jiayu , Roth Stefan , Zhang Sijia , Kopczak Anna , Georgakis Marios , Li Xinghai , Dutsch Alexander , Liman Thomas , Endres Matthias , Brough David , Green Jack , Wernsdorf Saskia , Fürle Christina , Carofiglio Olga , Zhu Jie , Asare Yaw , Group DEMDAS Study , Dichgans Martin , Sager Hendrik , Grosse Gerrit
Published: March 2023

The risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients experiencing early recurrent events. However, despite the enormous medical burden of this clinical phenomenon, the underlying mechanisms leading to increased vascular risk and recurrent stroke are largely unknown. Here, using a novel mouse model of stroke-induced recurrent ischemia, we show that stroke leads to activation of the AIM2 inflammasome in vulnerable atherosclerotic plaques via an increase of circulating cell-free DNA from the ischemic tissue. Enhanced plaque inflammation post-stroke results in plaque destabilization and atherothrombosis, finally leading to arterio-arterial embolism and recurrent stroke within days after the index stroke. We confirm key steps of plaque destabilization also after experimental myocardial infarction and in carotid artery plaque samples from patients with acute stroke. Neutralization of cell-free DNA by DNase treatment or inhibition of inflammasome activation reduced the rate of stroke recurrence after experimental stroke. Our findings present an explanation for the high recurrence rate after incident ischemic events in atherosclerotic patients. The detailed mechanisms uncovered here provide so far clinically uncharted therapeutic targets for which we show high efficacy to prevent recurrent events. Targeting DNA-mediated inflammasome activation after remote tissue injury represents a promising avenue for further clinical development in the prevention of early recurrent events.
Novel Hybrid-Relay Cooperative Communications Technique for Agriculture .
Authors: Kalu Chikezie Kennedy , Sakilu Olani Bekele , Ebhota Simeon
Published: March 2023

Objective – To investigate, and analyse the novel Hybrid-Relay Cooperative communications technique and algorithms which provides the possibility of obtaining improved system performance, with minimal cost, complexities, and overall energy consumption in wireless fading channels while retaining spectral efficiency to aid decision making processes for a more efficient and effective water-agriculture-food nexus.
Methods– Henceforth, the comparative performance and energy efficiency analysis of the fundamental cooperative MIMO techniques namely: Detect & Forward (DF), Amplify & Forward (AF) and the Coded cooperation were analysed with respect to the Hybrid Cooperative Communications technique. The methodical and data-driven analyses were carried out using MATLAB and Wireless Communications Systems Parameters.
Results – In harmony with the ‘Green Communications’ wireless communication theme; the excellent trade – off between performance (data rate) and energy efficiency is confirmed, which of course creates very good potential for use for an improved agricultural monitoring and management system.
Conclusion – The Hybrid-Relay Cooperative communications system serves as a basis for the comparative analysis of the aforementioned cooperative MIMO techniques and provides fundamental, but meaningful deductions and potentials with regards to efficient cooperative communications for innovative, efficient and effective water management for improved agricultural practices and a sustainable environment.
TOOL: MATLAB.
An Intelligent Cloud Broker with Service Ranking Algorithm for Validation and Verification of Cloud Services in Multi-cloud Environment
Authors: Nagarajan Rajganesh , P Vinothiyalakshmi , Thirunavukarasu Ramkumar
Published: March 2023

Cloud computing offers a widespread variety of services for the users. In multi-cloud environment, the service centric features are introduced to assist the cloud users from the multiple endpoints. In order to enhance the service availability, cloud brokerage is introduced into the multi-cloud environment that outperforms the effective utilization of required services. The primary objective of a cloud broker is to ensure about the services and its outcomes while offering them to a customer. The role of a traditional broker has the restrictions such as measuring the service trust, validity, and the future enhancement of the considered cloud services from the multi-cloud environment. Hence, the need for the intelligence feature is highly solicited in the cloud broker while working in a multi-cloud environment. The proposed intelligent cloud broker performs the validation and verification of service trust details by analysing the service trust factors such as service response time, sustainability, suitability, accuracy, transparency, interoperability, availability, reliability, stability, cost, throughput, efficiency, scalability of the cloud services. The customer’s feedback is taken into consideration for measuring the service trust factors before the service recommendation. In this proposed model, the Service Ranking (SR) values are calculated for the available cloud services. Additionally, the proposed model considers the newly arrived services during cloud services validation process by mapping its services with the available cloud services from the Service Collection Repository (SCR). Hence, this proposed model outperforms well in the process of recommending services to the cloud users.
Branch Retinal Vein Occlusion Treated with Anti VEGF, to Switch or not to Switch? Long Term Follow-Up
Authors: Shor Reut , Segal Ori , Greenbaum Eran , Cohen Ram , Trivizki Omer , schwartz shulamit , Loewenstein Anat , Rabina Gilad
Published: March 2023

Objectives
To evaluate visual outcomes after switching from Bevacizumab to Ranibizumab or Aflibercept in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO).
Methods
A retrospective, multi-center, observational study of BRVO patients treated with at least three Bevacizumab injections, prior to anti VEGF switch. Follow up period was 36 months and the primary study outcomes assessed changes in best corrected visual acuity (BCVA) after anti VEGF switch.
Results
A total of 263 eyes of 263 patients with a mean age of 71.5 ± 11.2 years of which 50% were of male gender met the inclusion criteria. Of these 175 eyes did not underwent switch while 88 eyes underwent anti-VEGF switch. There was not significant difference in mean age (p = 0.634) and gender (p = 0.269) between groups. Baseline BCVA of the no-switch group was 0.47 ± 0.43 logMAR (20/59 Snellen) Vs. 0.6 ± 0.49 logMAR (20/79 Snellen) (p = 0.031) in the switch group and at 36-months it was 0.41 ± 0.39 (20/51 Snellen) logMAR Vs. 0.54 ± 0.49 logMAR (20/69 Snellen) (p = 0.035) respectively. Difference between the rate of change in BCVA per year was insignificant between groups (p = 0.414). in multivariate analysis baseline BCVA was the single significant predictor for switch (Beta 0.137, p = 0.035). Patients with more than one anti VEGF switch suffer from decrease in BCVA.
Conclusions
Worse BCVA is a significant predictor for anti-VEGF switch execution, though the switch has no significant impact on the change in BCVA over time. Multiple anti VEGF switch is not recommended.
Prognosis nomogram for transhepatic arterial chemoembolisation with 125I seed implantation for first-branch portal vein tumour thrombus hepatocellular carcinoma：a comparative study of two statistical analysis methods
Authors: Zhao Xiao-Hui , Zhang Li-Lin , Zhao Lei , Zhao Yan , Li Hai-Liang , Cao Guang-Shao , Xu Shi-Jun , Guo Yuan , Hu Hong-Tao
Published: March 2023

Purpose: To investigate the efficacy of transhepatic arterial chemoembolisation (TACE) combined with 125I seed implantation in patients with first-branch portal vein tumour thrombus (PVTT) hepatocellular carcinoma (HCC), we tried to establish a nomogram to determine the prognosis of individual patients by comparing different statistical methods.
Materials and Methods: 97 patients who underwent TACE combined with PVTT 125I seed implantation served as the primary cohort. The median overall survival (mOS) was the main indicator of prognosis nomogram. Univariate analysis and LASSO regression were used to screen for variables. Selected variables were included in the multivariate Cox survival regression model, and a prognostic nomogram was developed. The performance of the nomogram was assessed in terms of calibration, discrimination, and clinical usefulness. The internal and external verifications were also evaluated.
Results: The mOS of all patients was 12.5 months (95%CI: 11.78–13.22). The final determination was made using the tumour burden, PVTT types, and platelet (PLT) count to establish a nomogram prediction model [C-index: 0.770 (95% confidence interval: 0.723–0.817)]. This model demonstrated good discrimination and calibration. Application of the nomogram to external verification data still yielded good discrimination [C-index: 0.764] and good calibration. The decision curve analysis demonstrated that the clinical validity of the model was clinically useful.
Conclusion: This nomogram can be used to predict the prognostic survival time of such patients and can help doctors make decisions in clinical practice. At the same time, the appropriate statistical methods should be selected based on clinical needs.
Comprehensive Analysis of Long Non-coding RNA,miRNA，and mRNA-associated Competitive Endogenous RNA Networks in the Peripheral Blood of Preterm Infants with Bronchopulmonary Dysplasia
Authors: Wang Yayun , Wei Yuqing , Ma Hongfang , Zhang Xue , Zhu Xiaobo , Xue Jiang , Wang Yibiao , Li Yufeng
Published: March 2023

Background: Bronchopulmonary dysplasia (BPD) is a complex disorder resulting from interactions between genes and the environment. The precise molecular etiology of BPD remains unclear. This study aimed to determine potential biomarkers and possible therapeutic targets of BPD through competitive endogenous RNA (ceRNA) network analysis and lay the foundation for future clinical research.
Methods: First, we downloaded the mRNA, miRNA, and long non-coding RNA (lncRNA) expression profiles of patients with BPD from the Comprehensive Gene Expression Database. We identified differentially expressed genes (DEGs), followed by functional enrichment analysis, construction of a protein-protein interaction network, and construction of ceRNA network.
Results: We obtained1286 DEGs, 77 differentially expressed miRNAs, and 104 differentially expressed lncRNAs. Functional enrichment analysis showed that DEGs were mainly involved in B-cell receptor signaling pathways, asthma, FcRI signaling pathways, cell apoptosis, the intestinal immune network that produces IgA, and Th17 cell differentiation signaling pathways. We constructed ceRNA network based on the predicted relationship between lncRNA-miRNA and mRNA-miRNA, including 6 lncRNAs, 11 miRNAs, and 56 mRNAs.
Conclusion: Through ceRNA network analysis, we identified six new lncRNAs that are potential biomarkers and therapeutic targets of BPD, thus opening up a new horizon for the prevention and treatment of BPD.
Development and Standardization of Gurukula Kangri Metacognition Awareness Scale in Higher Education Students
Authors: Kumar Narottam , Singh Udham
Published: March 2023

Authors have advocated for the inclusion of spiritual cognition awareness (SCA) as a domain in metacognition with metacognitive knowledge (MCK) and metacognitive regulation (MCR). It is in our understanding the knowledge comes from within (i.e., spirituality) are the innate ability to know and regulate own cognitive process. Previous literature supports the notion that spirituality has positive effect in students’ cognition, thus enhances their learning. The self-report assessment to measure metacognition as domain-specific ability associated to spiritual cognition (knowledge) is not found in previous literature. The authors have included the spiritual cognitive awareness as a domain in metacognition based on spiritual cognition theory, while tracing the descriptions as delineated in Indian psychological roots. This study elaborates the construction, development, and standardization of the 45-item Gurukula Kangri Metacognition awareness scale (GKMAS). The different properties of scale were confirmed by content validity, face validity (cognitive interview), demonstration of reliability (internal consistency, test-retest, split half), convergent validity and discriminant validity. The rigorous literature review has been carried out (for inclusion) before starting content and face validation process to fit SCA into metacognition. The 45-item GKMAS was administered on total 457 higher education students, received acceptable Cronbach’s alpha value for GKMAS and its SCA, MCK, and MCR. The study has also discussed implications of GKMAS in academic and corporate settings.
Remote imprinting of moiré lattices
Authors: Gu Jie , Watanabe Kenji , Taniguchi Takashi , Shan Jie , Mak Kin Fai
Published: March 2023

Two-dimensional (2D) moiré materials have emerged as an exciting platform for discoveries of new physics and device concepts 1-6. These materials are formed by overlaying two layered crystals with small differences in orientation or/and lattice constant, the direct coupling of which generates moiré potentials. The moiré materials (such as doping density) are highly tunable, but the moiré lattices, once formed, cannot be easily altered. Here we demonstrate electrostatic imprinting of moiré lattices onto a monolayer semiconductor. The moiré potential is created by a lattice of electrons that is supported by a Mott insulator state in a remote MoSe2/WS2 moiré layer. The imprinted moiré potential generates flat bands and correlated insulating states in the target material, which are detected by an exciton sensor. It can be turned on/off by a gate voltage that controls the doping density only in the moiré layer. We also illustrate the interplay between the electrostatic and structural relaxation effects for moiré imprinting as a function of the target and moiré layer spacing. Our results demonstrate a pathway towards the gate control of moiré lattices, including currently inaccessible symmetries, in an arbitrary 2D semiconductor or semimetal.
Designing, implantation and evaluation of a pediatric fever management program for nursing students: a mixed methods study
Authors: heidari haydeh , Saidi Reza
Published: March 2023

Background: Fever is one of the most common symptoms in children. However, the level of knowledge of nurses and parents regarding fever management is lower than expected. This study was conducted with the aim of developing a pediatric fever management program for nursing students.
Methods: This study applied exploratory mixed method which included 3 stages: developing a pediatric fever management plan and teaching this educational plan to 100 nursing students, interviewing with 20 students and parents regarding fever management plan, and designing a questionnaire and evaluating the opinions of students regarding the fever management plan. Participants included nursing students who were attending in pediatric internship course and parents of febrile children hospitalized in pediatrics unit. Data were analyzed using qualitative and quantitative data analysis methods.
Results: after analyzing qualitative data, three main themes identified: improving self-management ability in nursing students and parents of feverish children, behavior change and improving practices of students and parents. Quantitative results showed that, most participant completely agreed that, in the fever management plan, enough attention is paid to parents’ needs, the fever management plan leads to modification of parent practices regarding fever management, the fever management plan leads to behavioral changes in parents and 4. Generally, the fever management plan was satisfactory.
Conclusion: Results of our study showed that a pediatric fever management plan improved knowledge, self-management ability and practices of nursing students and parents of febrile children. These results can be used by healthcare managers for improving quality of cares given to febrile children.
Appendiceal Phlegmon as an intraoperative finding: A retrospective analysis
Authors: Conde Danny , Rodríguez Lina , Venegas David , Rey Carlos , Núñez-Rocha Ricardo E. , Nassar Ricardo , Vanegas Marco , Monsalve Catalina , Pinzón Pablo , Girón Felipe
Published: March 2023

Background
Emergency procedures due to acute surgical abdomen correspond to a great part of emergency surgeries. Appendicitis is the most common abdominal surgical emergency in the world. Intraoperative findings can represent a challenging scenario for the surgical team and its decisions. Appendiceal phlegmon/plastron presents in 3.8-7% of patients with appendicitis and can be considered as a challenging surgical scenario where expertise may gain a fundamental value in terms of decision-making process. Therefore, we present clinical courses and outcomes of 40 patients that underwent emergency surgery with these intraoperative findings from 2016 to 2018.
Methods
Retrospective study with a prospective database in which we described patients with emergent need for surgical procedure due to peritoneal signs with surgical findings of appendiceal phlegmon. Multivariate analysis was performed to prove the relationship between obesity, diabetes, and surgeon experience with any complication and colonic resection.
Results
40 patients underwent surgical procedure due to peritoneal signs with intraoperative findings of appendiceal phlegmon. Mean age was 51.9 (± 20.4). Procedures were performed based on intraoperative findings being appendectomy the most frequent (85%), followed by right hemicolectomy (10%) and partial cecum resection (5%). Three patients required reintervention. No mortalities were documented. Surgeries performed by junior surgeons have a higher probability to require colonic resections (P = 0.05, OR 4.05 ,95% CI), also obesity is associated with complications (P = 0.04, OR 1.44, 95% CI).
Conclusion
Finding of appendiceal phlegmon constitute a challenging surgical scenario in daily practice. Our patient’s complication rates are similar to those described in literature despite its emergent circumstances. Surgeons' expertise appears to be associated with outcomes. Further studies are needed to give clear recommendations.
Daisy Leaf Gentian Antagonism Protects against Adriamycin-induced Heart Failure in Mice
Authors: Liu Ying , Hou Xuxiao , Li Yunfeng , Zhao Jingshan , Liu Yalei , Liu Yu , Wang Haijun
Published: March 2023

Objective: This study aimed to evaluate the protective effect and underlying mechanisms of daisy leaf gentian, also known as bellidifolin (BEL), against heart injury in mice.
Methods: Mice were randomly divided into four groups: Control, ADM (ADM alone), ADM+BEL (ADM plus daisy leaf gentian ketone monomer), and ADM+CAP (ADM plus captopril). We sacrificed mice using cervical dislocation.Heart structure and function were evaluated using echocardiography and hemodynamic testing. The serum levels of creatine kinase,aspartate aminotransferase, lactate dehydrogenase, and brain natriuretic peptide were measured using enzyme-linked immunosorbent assays. Hematoxylin and eosin staining and Masson’s staining were used to detect myocardial pathological changes. TUNEL staining and electron microscopy were used to detect cardiomyocyte apoptosis. Transmission electron microscopy was used to observe ultrastructural changes in the cardiomyocyte nuclei and mitochondria.Immunohistochemical analysis,Western blot and real-time PCR assays were used to measure protein expression and mRNA levels of myocardial factors.
Results: ADM induced chronic heart failure in mice, and BEL improved the heart function in ADM-treated mice. Cardiomyocyte apoptosis was significantly increased in the ADM group, but apoptosis in the ADM+BEL and ADM+CAP groups was significantly reduced compared with the model animals. mRNA levels and protein expression of 78-kD glucose-regulated protein,brain natriuretic peptide,caspase-12, and phosphorylated eukaryotic cell translation initiation factor 2α were significantly higher in the ADM group. BEL or CAP successfully suppressed ADM-induced upregulation of these genes.
Conclusions: Daisy leaf gentian improved heart function and reduced cardiomyocyte apoptosis in mice following ADM-induced heart failure. The cardioprotective effect of daisy leaf gentian may be related to endoplasmic reticulum stress.
Boys Do Cry: Influences of Masculinity & Avoidant-Attachment Style on Post-Romantic Breakup Emotional Distress
Authors: Sherwood Morgen Joy , Steele Howard , Kathuria Chirinjeev
Published: March 2023

This investigation sought to replicate Simpson’s 1990 study “Influence of Attachment Styles on Romantic Relationships,” which found attachment style to be uncorrelated to intensity of emotional distress following a romantic breakup, except in avoidant men— who experienced significantly less emotional distress than all other people including avoidant women, even when relationship length and quality were statistically controlled. With updated measures for attachment style, emotional distress, and a more diverse sample, this study found Simpson’s result irreplicable. Of 488 individuals who had previously disbanded from a romantic partner, ex-partners with anxious tendencies experienced more emotional distress than ex-partners with avoidant tendencies, but highly avoidant men did not experience significantly less emotional distress than highly avoidant women. Gender did not have a significant effect on levels of emotional distress, even when participants shared similar levels of anxiety and avoidance. Discussion focuses on possible reasons for the newfound lack of gender difference among highly avoidantly-attached individuals, emotionality in relation to societal gender norms, and the role of attachment in romantic relationship breakups.
Appraisal of awareness of medical staff about preoperative patient blood management in Saudi Arabia: questionnaire based study
Authors: Hakami Nora Y. , Almohammadi Nouf I. , Alqahtani Raghad A. , Alsayel Nouf A. , Felimban Raed I. , Hindawi Salwa I. , Elmosaad Yousif Mohammed , Alharithi Nahed S. , Hjazi Ahmed M , Waggiallah Hisham Ali
Published: March 2023

Background
Patients blood management (PBM) is a comprehensive approach to optimizing the care of patients who might need transfusion. It involves the use of evidence-based strategies to reduce or avoid the need for allogeneic blood transfusions, while ensuring that patients receive safe and appropriate care. PBM includes strategies such as preoperative autologous donation, intraoperative cell salvage, and minimally invasive techniques to reduce bleeding. The purpose of this study is to assess medical staff awareness of preoperative patient blood management in Saudi Arabia
Methods
Between April 2022 and July 2022, data was collected using a 10-minute online (Google Forms) self-administered, anonymous, researcher-structured questionnaire adapted from previous studies and translated into both English and Arabic. The questionnaire was divided into three sections. The first section contained sociodemographic data, while the second section was used to estimate physicians' and nurses' knowledge of preoperative PBM. Two questions in Part 3 of the questionnaire were used to assess doctors' and nurses' preoperative PBM attitudes and practices.
Results
The average relationship between patients' blood management attitudes and levels of awareness. It was revealed that there was a positive attitude (p ≤ 0.005) as well as a high level of awareness (p ≤ 0.002). The effect of job, gender, or geographical distribution on PBM awareness, attitude, and practice was not significant.
Conclusion
Despite the fact that the majority of participants have a positive attitude and good awareness of PBM, more efforts should be implemented to improve PBM awareness, which was linked to increased transfusion practices and lower product costs.
Activation, control and T-bet+ B cell-mediated immune surveillance of endogenous retroviruses
Authors: Rauch Eileen , Amendt Timm , Krol Aleksandra Lopez , Lang Fabian , Linse Vincent , Hohmann Michelle , Keim Ann-Christin , Kreutzer Susanne , Kawengian Kevin , Buchholz Malte , Duschner Philipp , Grauer Saskia , Schnierle Barbara , Ruhl Andreas , Burtscher Ingo , Dehnert Sonja , Paul Stephanie , Schnare Markus , Kaufmann Andreas , Winkler Thomas , Huber Magdalena , Bauer Stefan , Yu Philipp
Published: March 2023

Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their role as anti-cancer immune targets or drivers of autoimmune disease. Here, we generated mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP (ERV-GFP) infected the murine germline. This enabled us to analyze the role of genetic, epigenetic and cell intrinsic restriction factors in ERV activation and control. We identified an autoreactive B cell response against the neo-self/ERV antigen GFP as a key mechanism of ERV control. Hallmarks of this response are spontaneous ERV-GFP+ germinal center formation, elevated serum IFN-γ levels and a dependency on T-bet+ B cells. Impairment of IgM B cell receptor-signal in nucleic-acid sensing TLR-deficient mice contributes to defective ERV control. Although ERVs are a part of the genome they break immune tolerance, induce immune surveillance against ERV-derived self-antigens and shape the hosts immune response.
Microstructure Phase Analysis and Process Optimization of ZL205A Metal Mold Casting
Authors: Huang Liang , Fang Yadong , Cao Yan , Wang Panfeng , Wang Chenfei , Wu Lili , Zakaria
Published: March 2023

The ammunition body drive structural parts are typical components in the weaponry industry, with large size and wall thickness, the parts need to bear large loads when working, so their internal filling quality and mechanical properties have quite strict acceptance criteria. In this paper, we take an elastomeric transmission structure part made of ZL205A alloy as the research object, and use the metal type gravity casting technology for casting trial production, analyze the quality and mechanical properties of the molded parts of ZL205A alloy parts under different process parameters, optimize the casting process parameters, get the optimal combination of process parameters, and obtain large ZL205A castings with less internal quality defects and high mechanical properties. To solve the current problem of immaturity of domestic casting process technology for this ZL205A alloy large parts and promote the development of China's weapon and equipment manufacturing industry in the direction of light weight.
Glycogen synthase kinase 3 controls T cell exhaustion by regulating NFAT activation
Authors: Liu Wen-Hsien , Yubing Fu , Wang Jinjia , Liu Chenfeng , Liao Kunyu , Gao Xianjun , Tang Ronghan , Fan Binbin , Hong Yazhen , Xiao Nengming , Xiao Changchun
Published: March 2023

Cellular immunity mediated by CD8+ T cells plays an indispensable role in clearance of bacteria and virus infection and cancers. However, persistent antigen stimulation of CD8+ T cells leads to an exhausted or dysfunctional state characterized by loss of effector function and highly expression of inhibitory receptors during chronic virus infection and in tumors. Numerous studies show that glycogen synthase kinase 3 (GSK3) controls the function and development in immune cells, but whether GSK3 exerts a function in CD8+ T cells is not clearly elucidated. Here we demonstrate that mice with deletion of Gsk3α and Gsk3β in activated CD8+ T cells (DKO) resulted in decreased CTL differentiation and their effector function during acute virus infection. In addition, DKO mice failed to control tumors due to increased expression of inhibitory receptors and augmented T cell exhaustion in tumor-infiltrating CD8+ T cells. Strikingly, anti-PD-1 immunotherapy substantially restored tumor rejection in DKO mice. Mechanistically, GSK3 regulates T cell exhaustion by suppressing TCR-induced nuclear import of NFAT, thereby in turn dampening NFAT-mediated exhaustion-related gene expression, including TOX/TOX2 and PD-1. Thus, we uncovered the molecular mechanisms underlying GSK3 regulation of CTL differentiation and T cell exhaustion in anti-tumor immune responses.
Development of O-ring Type Radiation Treatment Equipment Shielding Evaluation and Management Program
Authors: Choi Dong Hyeok , Ahn Sohyun , Kim Dong Wook , Choi Sang Hyoun , Kim Jin Sung
Published: March 2023

The objective of this study is to evaluate the effectiveness of O-ring type linear accelerator shielding using a developed program (O-ring Type Radiation therapy Equipment Shielding Evaluation, ORSE) that automatically evaluates Digital Imaging and Communications in Medicine Radiation Therapy (DICOM RT) plan files and applies them to determine the adequacy of the shielding. The shielding evaluation was conducted for a total of four treatment rooms including Magnetic Resonance Linear Accelerator (MR-LINAC), Halcyon, Tomotherapy. The analysis was performed using the program that analyzed DICOM RT plan files of patients who received treatment for five days. The program obtained the IMRT factor, which considered the Monitor Unit (MU), and the use factor, which considered the gantry angle. Based on the National Council on Radiation Protection & Measurements (NCRP)-151 report, shielding calculations were performed to determine the transmitted dose for each location behind the barrier, and the maximum number of treatable patients and the shield wall thickness were calculated based on patient data. To compare the results with the program, doses were measured over five days using a glass dosimeter for photon detection. The IMRT factors and Use factors obtained from patient data showed differences of up to 65.0% and 33.8%, respectively, compared to NCRP-151. Shielding evaluation conducted in each treatment room showed that the transmitted dose at every location was below 1% of the dose limit. The program results and detector results showed a maximum error of 0.003 mSv/week in transmitted dose. The ORSE program allows for the shielding evaluation results to the clinical environment of each institution based on patient data for the desired analysis period through straightforward manipulation.
Mortality and its predictors among mothers diagnosed with Postpartum Hemorrhage in Public Hospitals in Harari Region, Ethiopia
Authors: Eyeberu Addis , Yadeta Elias , Deressa Alemayehu , Alemu Addisu , Heluf Helina , mohamed Ahmed , Ahemed Fila , Beyene Andinet , Getachew Tamirat , Debella Adera , Birhanu Abdi
Published: March 2023

Background: Despite hemorrhage being recognized as a top-ranked preventable obstetric complication that causes maternal mortality, its burden remains high. Furthermore, there is scarce information on the death contribution of postpartum hemorrhage in Eastern Ethiopia.
Thus, this study aimed to assess the mortality and its predictors among mothers diagnosed with postpartum Hemorrhage in public Hospitals in Harari region, Eastern Ethiopia.
Methods: We conducted a retrospective cohort among women with postpartum hemorrhage in public hospitals of Eastern Ethiopia. All women with postpartum hemorrhage were followed for 11 years (from October 1/ 2012 to October 1/ 2022) retrospectively. Statistical analysis was conducted with STATA version 14. Kaplan–Meier curves together with a log rank test were used to estimate the survival time and showed the presence of differences among groups. Cox Proportional Hazard (CPH) model was used to determine the association between independent predictors and mortality due to postpartum hemorrhage.
Result: We found that the proportion of death among mothers with postpartum hemorrhage was 17.8 % (95%CI; 14.8%-21.3%). The median time to death was 2 days (IQR=1-3 days). The survival status of mothers diagnosed with postpartum hemorrhage declined to 75% on the 2nd day of admission, then after the survival chance remains relatively constant. Prolonged labor (AHR=19.16, 95%ci; 4.02-91.28), and being anemic (AHR=2.12; 95%CI; 1.10-4.09) were the
predictors of mortality among mothers with postpartum hemorrhage.
Conclusions: Around one out of five mothers died due to postpartum hemorrhage. Prolonged labor and the co-existence of anemia were significant predictors of mortality among mothers due to postpartum hemorrhage. Thus, emphasis has to be given to prevent and treat postpartum hemorrhage accordingly by improving the health care delivery system at all levels of health institutions, preventing prolonged labor, and working on the mothers to make them aware about
the possible risk factors of postpartum hemorrhage.
A comprehensive analysis of Notch signalling genes in breast cancer: Expression pattern and prognostic significance
Authors: Sofi Shazia , Qayoom Hina , Khaliq Nighat , Mir Manzoor Ahmad , Shah Mohd Zahoor ul Haq
Published: March 2023

The most recurrent type of cancer among women is breast cancer which is an intricate disease with high intratumoral and intratumoral heterogeneity. Such variability is a key factor in the failure of current treatments and the emergence of resistance. It is crucial to develop novel therapeutic options to enhance the prognosis for breast cancer patients due to the limitations of current therapy and the unavoidable formation of acquired drug resistance (chemo and endocrine) as well as radio resistance. Poor clinical results in the treatment of breast cancer that is resistant are associated with deregulated Notch signalling within the breast tumor and its tumor microenvironment (TME). In this research, a bioinformatics approach was used to check the expression pattern, the role, as well as the prognostic and diagnostic significance of the deregulated Notch-related genes in BC patients. The study demonstrates that highly dysregulated genes (NOTCH4, CCND1, JAG1, DLL1, MAML2, and EGFR) can be used as biomarkers to identify breast cancer patients with poor prognosis and as potential targets for therapeutic intervention. The study found that 6 genes—NOTCH4, CCND1, JAG1, DLL1, MAML2, and EGFR—out of 22 tested genes showed a significant log2 fold change. Our study revealed that Luminal Breast Cancer patients display a high expression of the CCND1 gene in comparison to its expression in normal. The results of our study also depicted that the patients with elevated levels of NOTCH-related gene expression displayed better relapse-free survival with p < 0.05. Moreover, we analysed these deregulated notch genes that play an important role in various cellular and molecular processes. The study shows that these highly deregulated screened genes could be utilized as the Biomarkers that help to reveal poor prognosis and could act as targets for treating BC.
Populations across species ranges respond differently to habitat loss and fragment
Authors: HASUI ERICA , Martensen Alexandre Camargo , Uezu Alexandre , Pimentel Rafael Guerra , Ramos Flavio Nunes , Ribeiro Milton Cezar , Metzger Jean Paul
Published: March 2023

Context
Conservation strategies assume all species populations respond equally to habitat loss, but we investigated sensitivity patterns and tested two hypotheses: 1) equal sensitivity across the range or environmental suitability, and (2) highest sensitivity in range edge populations or at low environmental suitability. We also evaluated if species traits such as dispersal ability, habitat specialization, and range size were associated with sensitivity responses.
Methods
We studied the Brazilian Atlantic Forest across 179 landscape sites. We used two model types to analyze sensitivity to habitat transformations and performed a PCA and permutational MANOVA framework to link species traits to sensitivity patterns.
Results
Our study shows that populations within a species' range can have different patterns of sensitivity to habitat transformations. We found four sensitivity patterns, which were not related to species traits. Biogeographic and landscape factors interact to affect population abundances, resulting in antagonistic or synergistic effects. These interactions can change population responses to habitat transformations depending on their range position or environmental suitability.
Conclusions
The study found different patterns of sensitivity to habitat transformation within species. Conservationists should avoid generalizing species sensitivity without considering range position and environmental suitability. Wildlife managers should protect vulnerable areas along the range edge, especially for species sensitive to habitat transformations. For Atlantic Forest endemic species, the vulnerable areas are in the transition region between the Atlantic Forest and the Cerrado.
Annual variation of red blood cell number and composition of erythroid cells in circulating blood and head kidney of golden grey mullet (Chelon auratus Risso, 1810)
Authors: Soldatov Aleksander A. , Rychkova Valentina N. , Kukhareva Tatyana A. , Rokotova Anna G.
Published: March 2023

The changes in the number of erythrocytes in the blood and the production of erythrocytes by the hematopoietic tissue of the golden grey mullet (Chelon auratus Risso, 1810) during the annual cycle were studied. Catching and delivery of fish to the aquarium was carried out monthly. The content of immature erythroid forms was determined: pronormoblasts, basophilic and polychromatophilic normoblasts, in the head kidney (pronephros) and circulating blood. It has been established that the processes of erythropoiesis in the hematopoietic tissue of the golden grey mullet proceed irregularly. The active production of erythroid mass is mainly confined to the post-spawning period. This is evidenced by an increase in the content of immature erythroid forms in the head kidney and blood. This coincides with a general increase in the number of red blood cells in the circulation system and indicates a shift in the erythrocyte balance in favor of production processes. In the rest of the time, the processes are opposite. It is assumed that this is due to the peculiarities of the organization of the red blood system, which excludes the regular production of erythropoietin in the kidneys.
Inferring the temperature from planar velocity measurements in Rayleigh-Bénard convection by deep learning
Authors: Teutsch Philipp , Käufer Theo , Mäder Patrick , Cierpka Christian
Published: March 2023

The simultaneous, spatially- and temporally-resolved direct measurement of velocity and temperature fields in Rayleigh-Bénard experiments is laborious, expensive and sometimes not even feasible. Hence, we assess the capabilities of a deep learning model to support such measurements and reduce the necessary effort. Here, we use a u-net-based model to predict the temperature from the corresponding velocity field obtained from measurements in Rayleigh-Bénard convection at Pr = 7.1 and Ra = 2× 105, 4×105, 7×105. We conduct a hyper-parameter search and ablation study to ensure appropriate training convergence and test different architectural variations for the u-net. We define two application scenarios, one in which the u-net is trained with data of the same experimental run and one in which the u-net is trained on data of different Ra. Our analysis showed that the u-net can predict temperature fields similar to the measurement data and preserves typical spatial structure sizes. Moreover, the analysis of the heat transfer associated with the temperature fields unveiled that the results are physically reasonable and are in good agreement with the ground truth data when the u-net is trained with data of the same experimental run. We conclude that deep learning has the potential to supplement measurements and can partially replace the requirement of additional temperature measurements.