bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital transformation of product assortment management business processes
Authors: Allakhverdieva Sabina Ekmanovna , Ganyukova Natalia Pavlovna , Cherkasova Galina Sergeevna
Published: November 2023

The problem of managing the assortment of goods in retail is considered, a solution to this problem is proposed through digital transformation. It is emphasized that changes in consumer preferences can have a negative impact on business if companies are not ready to respond quickly to them. Goods assortment managing becomes a criti-cal factor for ensuring profitability. The formalization of the economic and mathematical characteristics of the commodity matrix and its impact on the trade policy of the enterprise is discussed. The importance of building an assortment matrix for each retail facility is emphasized, which contributes to more effective analysis and management of the assortment. It is noted that successful product policy management includes not only the assortment, but also pricing, quality of goods, product promotion and sales promotion. To achieve maximum efficiency, it is recommended to use information and analytical systems. A Data Mining methodology is proposed for analyzing the commodity matrix and forecasting demand. The analysis of the product matrix helps to automate the calculation of the sales forecast for a certain period of time, which contributes to more accurate inventory planning and timely formation of orders. The importance of the company's assortment policy is emphasized, which can increase customer demand, reduce costs and increase the marginality of retail activities. The development and implementation of an information and analytical product matrix management system can automate many processes in retail and simplify the management of retail business processes, which contributes to the optimization of the product range and customer satisfaction. In practice, this approach can significantly simplify the management of retail business processes and increase the competitiveness of the enterprise in a dynamic trading environment.
Ten Clusters Of Rural Development Articles Using Social Network Analysis
Authors: Darto Darto , Aditiany Savitri , Myrna Rita , Muharram Riki Satia
Published: November 2023

This article presents an in-depth analysis of Rural Development literature through a Social Network Analysis approach. The purpose of the research is to identify and categorize articles related to Rural Development into ten main clusters, focusing on the patterns of interaction and relationships between them. By applying advanced social network analysis methods, this research details the network structure emerging from this literature, revealing how the articles are interconnected and form groups based on relevant themes or concepts. Additionally, articles that have a central role in the network are also identified, highlighting their significant contribution to the understanding of key aspects of Rural Development. The results showed that the study highlighted gaps that indicate the direction of the future research agenda in rural development, with a focus on inter-regional collaboration in Asia and developing countries. Despite limitations, including limited databases and author subjectivity, this study recommends expanding the sample with broader keywords and databases and benchmarking with other bibliometric analysis tools in the future.
Electronic Goods/Services Procurement Policy Implementation at the Ministry of Energy and Mineral Resources
Authors: Ginting Nova Magdalena , Bekti Herijanto , Utami Sawitri Budi
Published: November 2023

The government institution responsible for managing energy and mineral resources in Indonesia is the Ministry of Energy and Mineral Resources (MEMR). In carrying out its responsibilities, the MEMR procures goods/services to support its operational activities. To ensure transparency, accountability, and effectiveness in using the state budget, crucial to research the effective implementation of electronic procurement of goods and services in the MEMR. This research examines how the MEMR has implemented electronic procurement of goods and services. Based on the literature review, similar research has yet to be conducted. The research methodology used is qualitative descriptive. The findings of this study demonstrate that the MEMR's e-procurement policy has been successfully implemented. However, several things become input from researchers, namely that the MEMR is serious about improving the standards and maturity of e-procurement services; improving a professional work culture with integrity and optimizing the use of information technology in e-procurement; increasing communication with Government Goods/Services Policy Agency, and in order to have good legal standing in strengthening the procurement of goods and services in Indonesia, it is necessary to encourage the creation of a legal basis for goods and services procurement regulations in the form of laws.
Implementation Of Public Housing Management Policy: A Case Study In Rusunawa Of Cimahi, West Java, Indonesia
Authors: Kushendar Deden Hadi
Published: November 2023

Insufficient and affordable vertical housing (rusunawa) availability is still emerging as an alternative option for temporary residence for low-income individuals. Therefore, this study purposes to explore the implementation of Rusunawa management policies managed by local governments in Indonesia. The theoretical framework used to analyze policy implementation is based on Kearns and Lawson's (2008) concept, which examines four factors: 1) the policy itself, 2) implementing agencies, 3) inter-organizational relations, and 4) social and political factors. This research adopts a qualitative case study approach, focusing on three Rusunawa (vertical housing) facilities managed by the Cimahi Government. The data were collected within interviews with 18 respondents using purposeful sampling, employing open-ended questions complemented by observation and analysis of relevant documents. The implications of this research highlight the requirement for public rental housing management policies to consider the income criteria of prospective residents, rental period duration, and budget allocation for expanding the Rusunawa Public Service Unit (PSU), effective communication and information dissemination channels, and improved Rusunawa management practices. The findings underscore the socio-economic factors influencing the beneficiaries of general rental housing policies, along with the budgetary requirements for expanding the Rusunawa PSU, optimizing communication and information channels, and enhancing the overall management of Rusunawa facilities.
Unlocking the Power of Employee Engagement: Unveiling the Key Indicators in Public Sector Organizations
Authors: Yunus Muhammad , Hans Amril , Yani Andi Ahmad , Sangkala Sangkala , Nursadik Muhammad , Susanti Gita , Abdullah Muhammad Tang , Hidayat Andi Rahmat
Published: November 2023

This article proposes to explore the concept of employee engagement in the context of regional government, finding out its antecedents and implications for organizational performance, with a case study on the Provincial Government of South Sulawesi, Indonesia. This study used a quantitative approach with a survey method to collect data from South Sulawesi Provincial Government employees with 3,799 total respondents. This study implies descriptive quantitative analysis methods in analyzing data to find out the variables that contribute to the rigorous concept.  This study analyses six main indicators in measuring the quality of Employee Engagement, namely supervisor evaluation, teamwork, growth opportunities, work-life balance, behavioral fairness, and effective communication. The results showed a high level of Employee Engagement among South Sulawesi provincial government employees, with an average overall percentage of 79.46% and the category "very high."  These results indicate high levels of employee satisfaction and engagement in achieving organizational goals. This research provides important insights into the potential and relevance of Employee Engagement in improving performance and public services in public sector organizations. These findings provide a foundation for public sector organizations to better understand and utilize employee engagement as a key to achieving excellence in public services and achieving overall organizational goals.
Towards A More Balanced Approach to Addressing Game Adaptation Infringement in China
Authors: Deng Zhaoxia
Published: November 2023

While game adaptations have enriched people’s cultural lives, they also give rise to many legal disputes. The current copyright regime in China fails to acknowledge the core role of the right of adaptation in copyright theory and provides scant protection for video games. This allows game developers to clone or re-skin games at the expense of bona fide creators, thereby discouraging innovation and stifling creativity. This paper suggests that the normative target of the right of adaptation differs from that of the right of reproduction, despite their considerable overlap. This notion is strengthened by the exploration from the perspective of game design. Drawing on US judicial practice, this paper proposes a new three-step test to address game adaptation infringement in China. If strictly implemented, this test would avoid unduly restraining competition and follow-on innovation and interfering with the reasonable interests of the original creators
Assessing the efficiency of the forestry sector in EU countries
Authors: Staňková Michaela , Popelová Pavlína , Pipíška Tomáš
Published: November 2023

This paper deals with a quantitative assessment of the production efficiency of the forestry sector in EU countries, which is largely neglected in the literature. Only a few studies have been conducted so far, processing data mainly in the first half of the last decade. In contrast to these studies, in this article we focus on the period between 2016 and 2020. Therefore, the main objective of this paper is to compare the efficiency of the forest sector to fill the gap. The empirical results of this study show that the leaders in this sector are Germany, Finland, and the Czech Republic. These countries are fully efficient throughout the period under review. In contrast, Bulgaria lags far behind, with an efficiency score typically around 35%. The results of the cluster analysis show that although countries have similar characteristics, their efficiency scores are not necessarily at the same level.
Strategi Pengembangan Layanan Perpustakaan Keliling di Dinas Perpustakaan dan Kearsipan Kabupaten Solok Provinsi Sumatera Barat
Authors: Ayu Yun Fitra
Published: November 2023

Perpustakaan umum berkewajiban memberikan pelayanan informasi yang tepat dan merata kepada seluruh masyarakat melalui kegiatan perpustakaan keliling. Tujuan dari penelitian ini adalah mendeskripsikan strategi pengembangan layanan perpustakaan keliling di Dinas Perpustakaan dan Kearsipan Kabupaten Solok Provinsi Sumatera Barat. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif. Data diambil melalui observasi, wawancara dan dokumen kegiatan perpustakaan keliling. Hasil dari penelitian sebagai berikut: (1) perpustakaan keliling di Dinas Perpustakaan dan Kearsipan Kabupaten Solok Propinsi Sumatera Barat perlu menambah titik layanan dan menambah jumlah kunjungan setiap tahunnya; (2) Dinas Perpustakaan dan Kearsipan perlu meningkatkan kepedulian terhadap aktivitas perpustakaan keliling dengan kebijakan yang mendukung pengembangan perpustakaan keliling. Bentuk kebijakan yang dilaksanakan selama ini adalah memberikan anggaran tiap tahun untuk penyelenggaraan perpustakaan keliling, kebijakan dalam sarana dan prasarana perpustakaan keliling, fasilitas perpustakaan keliling, dan koleksi yang dilayankan. Strategy for developing mobile library services at the Library and Archives Service, Solok Regency, West Sumatra Province. Public libraries must provide accurate and equitable information services to the community through mobile library activities. This study describes the strategy for developing mobile library services at the Library and Archives Service, Solok Regency, West Sumatra Province. The research method used is qualitative with a descriptive approach. Data were taken through observation, interviews, and documents on mobile library activities. The results of the research are as follows: (1) mobile library at the Library and Archives Service, Solok Regency, West Sumatra Province, by adding service points and increasing the number of visits each year and (2) increasing awareness of mobile library activities, this can be seen from the policies given by Regional Libraries for the development of mobile libraries. The form of the policies implemented so far is to provide an annual budget for implementing mobile libraries, policies on mobile library facilities and infrastructure, mobile library facilities, and the collections used.
ENTERIJERSKO UREĐENJE KAFETERIJE U GRADSKOM JEZGRU
Authors: Rajić Jovana
Published: November 2023

Rad čine istraživački i projektantski deo, koji proizilaze jedan iz drugog. Kroz pregled istorije kafeterija i ugledne primere dobija se uvid u način oblikovanja enterija, koji za cilj ima da izgradi identitet brenda stvarajući ugodno i toplo mesto za korisnike.
PRIMENA PERFORIRANIH BRISOLEJA ZA SMANJENJE INSOLACIJE NA FASADAMA
Authors: Tomić Aleksandra , Bajšanski Ivana
Published: November 2023

U ovom radu analirizani su tipovi, karakteristike i značaj brisoleja, kao arhitektonskog elementa, sa ciljem smanjenja insolacije na fasadama. Pored toga, ovaj rad stavlja akcenat  na značaj primene digitalnog i parametarskog dizajna u arhitekturi. Istraživanje obuhvata kreiranje izgleda brisoleja primenom parametarskog dizajna, primenu na konkretnom primeru, sprovođenje niza simulacija i analizu i upoređivanje rezultata. Dobijeni rezultati pokazuju da primena brisoleja značajno utiče na smanjenje insolacije, a primena digitalnog dizajna nudi mogućnost variranja velikog broja parametara.
IDEJNI PROJEKAT „BENEATH“ - STANOVANJE ISPOD POVRŠINE ZEMLJE
Authors: Šušak Anastasija
Published: November 2023

Idejni projekat „Beneath“ bavi se rešavanjem problema stanovanja u ekstremnim uslovima, odnosno, područjima stalnih zemljotresa, postavljanjem ove funkcije ispod nivoa zemlje. Preispituje način života u ovakvim uslovima i nastoji da zadovolji osnovne potrebe čoveka. Predstavlja stambenu zajednicu koja se kombi­nuje sa dodatnim sadržajima, čime se dobija nezavisna struktura.
IDEJNO REŠENJE VERTIKALNOG KAMPA U CENTRAL PARKU
Authors: Đurić Katarina
Published: November 2023

Projekat se bazira na stvaranju savremenog smeštaja za jednu od najstarijih rekreacija-kampovanje. Kao adekvatna lokacija bira se Central park u Njujorku. U sadržaj kampa se uvrštava sve ono što je kamperima različitog uzrasta i preferenci potrebno tokom boravka. Fasada je u vidu ogledala, čime se kamp ,,kamuflira“ i stapa sa postojećim okruženjem.
РАЗВОЈ РОБОТСКЕ ЋЕЛИЈЕ СА SCARA РОБОТОМ ЗА РУКОВАЊЕ СТАТОРИМА МОТОРА
Authors: Бабић Игор
Published: November 2023

Рад се састоји из две целине – теоријске и експерименталне. Теоријска целина ће бити обухваћена другим поглављем , где ће бити описани основни појмови, дефиниције, начин рада и карактеристике роботских конфигурација. Након тога, у експерименталном делу, који обухвата треће поглавље, биће приказан рад робота у лабораторијским условима, симулација у софтверу за програмирање робота (енг. ориг. SRS скраћено од Stäubli Robotic Suite) као и процес пројектовања и развоја механизма за слагање и изузимање (енг. ориг.  stacker/destacker).
GAZERECORDER: MENGAMATI ATENSI PADA SISWA SEKOLAH MENENGAH ATAS MENGGUNAKAN EYE TRACKER
Authors: Taim Aeda Andianturi , Tiatri Sri , Tji Beng Jap
Published: November 2023

Atensi dapat bergeser dengan sangat cepat dari satu hal ke hal berikutnya, dan oleh karena itu atensi dapat didiskusikan menjadi orientasi overt yaitu tindakan selektif pada suatu item dengan menggerakkan mata ke titik ke arah itu, dan orientasi covert mampu mengalihkan fokus secara mental tanpa menggerakan mata. Pergerakan mata ini dapat menjadi indikasi untuk mengamati atensi. Tujuan penelitian ini adalah mengidentifikasi atensi dalam proses membaca bagi siswa sekolah menengah. Penelitian ini menggunakan metode eksperimen semu dengan desain posttest only one group design dan melibatkan 3 peserta kelas 1 dan kelas 3 SMA. Peralatan yang digunakan adalah webcam dengan perangkat lunak GazeRecorder  sebagai alternatif eyetracker yang telah digunakan dalam proses uji coba awal. Analisis deskriptif digunakan untuk mendapatkan profil perhatian siswa SMA dengan menggunakan video monitoring dan analisis korelasional untuk mendapatkan data perbedaan daya dan tingkat kesulitan alat ukur yang dikembangkan. Hasil dari penelitian menunjukkan bahwa atensi dalam membaca dapat diidentifikasi secara efektif melalui teknologi pelacak mata (gazerecorder). Attention can shift very quickly from one thing to the next, and therefore attention can be discussed as overt orientation i.e. selective action on an item by moving the eye to a point in that direction, and covert orientation being able to mentally shift focus without moving the eye. This eye movement can be an indication to observe attention. The purpose of this study was to identify attention in the reading process for high school students. This study used a quasi-experimental method with a posttest only one group design and involved 3 participants in grade 1 and grade 3 high school. The equipment used is a webcam with GazeRecorder software as an alternative to the eyetracker that has been used in the initial trial process. Descriptive analysis was used to obtain the attention profile of high school students by using video monitoring and correlational analysis to obtain data on the difference in power and the level of difficulty of the measuring instrument developed. The results of the study indicate that attention in reading can be identified effectively through eye tracking technology (gazerecorder).
ASPEK PEMBANGUNAN BERKELANJUTAN DALAM POLITIK HUKUM PEMBENTUKAN PERATURAN PERUNDANG-UNDANGAN DI INDONESIA
Authors: Perdana Rian Achmad , Aprilia Indah Siti
Published: November 2023

Indonesia sebagai negara hukum civil law mengutamakan hukum tertulis dalam peraturan perundang-undangannya, tentunya pembentukan peraturan perundang-undangan itu tidak terlepas dari politik hukum kebijakan. Dalam rangka menciptakan hukum yang berkemanusiaan dan melindungi rakyat Indonesia tentunya perlu dibuat sebuah kebijakan yang berkemanusiaan dan menunjang adanya pembangunan berkelanjutan. Metode penelitian yang digunakan adalah yuridis normatif. Adapun kesimpulan dari penelitian ini adalah pembentukan peraturan perundang-undangan di Indonesia yang berlandaskan pembangunan berkelanjutan dipengaruhi oleh hubungan hukum, kebijakan, dan birokrasi itu sendiri, dan tentunya perlu disempurnakan dari segi struktur hukum yaitu sumber daya manusianya, substansi hukum, yaitu peraturan perundang-undangan yang dibuat harus berdasarkan atas tujuan untuk melindungi manusia, dan budaya hukum perancang peraturan perundang-undangan serta budaya hukum masyarakatnya harus mampu saling adaptasi.
PERAN SELF-ESTEEM TERHADAP PERILAKU KONSUMTIF DENGAN KONFORMITAS SEBAGAI MEDIATOR PADA DEWASA AWAL PENGGUNA E-COMMERCE
Authors: Wijaya Rysnawaty , Kurniawati Meike , Ninawati Ninawati
Published: November 2023

Clothing can affect the level of self-confidence and self-esteem of individuals. This affects individual buying behavior, such as buying clothes and accessories to keep up with the latest fashion trends or it called consumptive behavior. Today's buying activities can be done easily, quickly, and anywhere through e-commerce. Trends that exist around individuals spread through several social groups. The existence of social groups also influence individuals in their behavior to adjust and want to be the same as them or also called conformity. Therefore, this study aims to determine the role of self-esteem on consumptive behavior with conformity as a mediator in early adult e-commerce during the COVID-19 pandemic. The study had 235 research participants ranging in age from 18 to 28 years, domiciled in Jakarta, Bogor, Depok and Tangerang (Jabodetabek), and shopped using e-commerce applications within the last 3 months. Based on the results of the regression analysis of conformity, self-esteem and consumptive behavior, the results obtained are F value (2, 234) = 105,609, p = 0.000, R2 = 0.477 the results indicate that their is a significant role for conformity and self-esteem together by 47.7% towards consumptive behavior in early adulthood. Based on the results of the analysis of the role of conformity as a mediator, the results of the indirect effect of self-esteem on consumer behavior = 0.2622, BootLLCI = 0.2325, BootULCI = 0.3556, direct effects = .0805, LLCI = -.0154, ULCI = 0.1764. The results show that self-esteem affects consumptive behavior in early adulthood because it increases conformity.
The fulfillment of reproductive rights in Ukraine: balancing the EU standards and the challenges of the war
Authors: Kashyntseva O. Y. , Pokalchuk O. Y.
Published: November 2023

The article discusses the importance of ensuring reproductive rights in Ukraine, particularly amidst the challenges posed by war and the need to align with EU standards. The authors emphasize the crucial role of reproduction and bioethics in protecting human life and dignity during armed conflicts. The article underscores the importance of upholding international legal principles and conventions related to reproductive rights and healthcare, including informed consent, non-discrimination, and the protection of privacy and confidentiality. Ukraine's progress towards aligning its national legislation with the EU, as part of its efforts to acquire candidate country status, is also highlighted.
Narrativas de correlação do comportamento alimentar e a saúde mental de profissionais da atenção primária sob ótica de uma nutricionista
Authors: Silva Santana Gabriela , Neves Morellib Núbia
Published: November 2023

Atualmente, vivenciamos a era da produtividade excessiva, afetando as singularidades dos indivíduos como: rotina, cultura, religião e etc. A Atenção Básica é a porta de entrada do usuário para os sistemas de saúde e, devido a uma série de fatores, incluindo falta de recursos humanos, alta demanda e estrutura física, os trabalhadores acabam se sentindo sobrecarregados. Este estudo tem como objetivo reflexões sobre minhas experiências nas refeições junto com os funcionários de uma Unidade de Saúde da Família (USF) no município de Santos, São Paulo. Reflexões envolvendo o ato de comer e a comensalidade, segundo o guia alimentar para a população brasileira e os espaços de refeições e descanso dentro da unidade de saúde. A Historiobiografia de Critelli como metodologia de análise e reflexão para apoiar possíveis melhorias no cuidado nutricional. As reflexões acarretaram na falta de espaço físico para realizar as refeições e descanso foi o ponto central para a discussão, colaborando para a falta de atenção dos trabalhadores no momento da alimentação, causando estresse no ambiente de trabalho e, como consequência, afetando a saúde do trabalhador e do usuário, pois prejudica a qualidade da assistência realizada. Conclui-se que é preciso um olhar sensível e crítico dos Gestores de Saúde e dos Conselhos Federais e Regionais que regulamentam as profissões de saúde no Brasil para que os trabalhadores possam obter momento digno de alimentação e descanso e, assim, uma boa qualidade de vida para cuidar do próximo.
Estética e gestão de resíduos: teoria e prática em discussão
Authors: Ronchi Juliana , Ribeiro Maria Lúcia , Botta Ferrante Vera Lúcia Silveira , Marquezi Machioni Maria Eduarda
Published: November 2023

Nesse artigo a geração e o descarte de resíduos sólidos dos serviços de estética e cosmetologia são colocados em pauta, avaliando-se como tais questões são trabalhadas nas disciplinas do curso de estética de uma universidade do interior paulista. O recorte de pesquisa se deve à demanda social crescente por serviços em estética, que deve ser acompanhada das questões de avanço sustentável da sociedade e da natureza no que tange à preservação ambiental. Para tanto adotou-se o caminho metodológico de, além de pesquisa bibliográfica e teórica, conduzir a aplicação de questionários a estudantes e realizar entrevistas semiestruturadas com professores e egressos. Foi analisada a história pedagógica do curso de Estética avaliado e discutida a percepção dos alunos quanto à relação da gestão de resíduos com a prática da estética. No tocante aos resultados, destacaram-se positivamente as abordagens teóricas referentes aos cuidados com o meio ambiente e chamou a atenção a discrepância com o conhecimento de procedimentos práticos apresentados pelos estudantes. Isso realça os retornos sociais pertinentes à essa pesquisa que são acima de tudo, buscar evidenciar a invisibilidade dos resíduos provenientes das práticas de estética e cosmetologia.
Legal Protection For Investors of Government Bonds Whose Clauses Do Not Have A Maturity Period
Authors: Shandietrysno Adrianus Jeffri , Chumaida Zahry Vandawati , Subagyono Bambang Sugeng Ariadi
Published: November 2023

The state in running its government needs funds with the aim of national development and maintaining the stability of the country's economy. One of the funds obtained is through debt instruments, both domestic debt and foreign debt. The government avoids foreign debt, thus optimizing domestic debt with consideration so that the public can participate in raising funds for national development. With this goal, the government issued government bonds or better known as Government Bonds (SUN). Government Bonds are securities in the form of debt recognition letters in rupiah and foreign currencies guaranteed by the payment of interest and principal by the Republic of Indonesia, in accordance with the validity period. However, the SUN issued in 1950 by the government, has no perpetual bond. Unlike the SUN issued today, there is a maturity period and guaranteed by interest and principal payers as stipulated in Law Number 24 of 2002 concerning Government Bonds. Meanwhile, the SUN issued in 1950 has no time period, so it does not provide legal certainty and legal protection to holders of the 1950 SUN, even though the SUN was issued by the same government.
Static and dynamic wireless charging system for electric vehicle
Authors: Jithin Antony , Sasi Akshath , Jaison Chris , Bensen A. J. , Reghuraj A. R.
Published: November 2023

Electrified transportation will help to reduce greenhouse gas emissions and petrol prices. Electrified transportation demands that a wide variety of charging networks be set up, in a user-friendly environment, to encourage adoption. Wireless electric vehicle charging systems (WEVCS) can be a potential alternative technology to charge electric vehicles (EVs) without any plug-in problems. This paper outlines the currently available wireless power transfer technology for EVs. In addition, it also includes wireless transformer structures with a variety of ferrite shapes, which have been researched. WEVCS are associated with health and safety issues, which have been discussed with the current development in international standards. Two major applications, static and dynamic WEVCS, are explained, and up-to-date progress with features from research laboratories, universities, and industries is recorded. Moreover, future upcoming concepts-based WEVCS, such as ‘‘vehicle-to-grid (V2G)” and ‘‘in-wheel” wireless charging systems (WCS) are reviewed and examined, with qualitative comparisons with other existing technology.
Civil society as a subject of the formation of the veterans reintegration system
Authors: Seiko Natalia , Zakharina Tetiana
Published: November 2023

The article examines the peculiarities of interaction between state authorities and civil society organizations in the context of the formation of a system of reintegration of veterans. Special attention is focused on the analysis of legal aspects of interaction between civil society and the government.

The generalized experience of theoretical research on the problem of defining civil society as a subject of interaction with state authorities is presented. Effective forms of interaction of cooperation subjects have been determined. The basic model of bilateral interaction between civil society and state authorities in the system of reintegration of veterans is presented.

The purpose of the article is to determine the place of civil society as a subject of interaction in the system of state policy on the reintegration of veterans. To achieve the goal, the following tasks are to be solved: clarify and specify the conceptual apparatus of the research problem based on the study of leading scientific experience and normative acts; determine the main legal forms of civil society interaction with state authorities in the system of reintegration of veterans; analyze the level of influence of civil society on decision-making depending on the form of public participation and, based on this, propose a model of the system of reintegration of veterans, in which civil society acts as an active subject of interaction. In the course of the research, the methods of theoretical analysis and generalization and the modeling method were used.

The scientific novelty of the research lies in revealing the role of civil society in the implementation of the policy of reintegration of veterans in today's conditions. The practical significance of the study lies in the development of a two-way model of interaction between civil society and the state in the formation of a system of reintegration of veterans.

The conclusions confirm the importance of defining civil society as a subject in the formation of the system of reintegration of veterans, and define the prospects for further research.
Formation of professional communicative competence of medical profile specialists under conditions of complication of social-professional interactions
Authors: Kischuk Vitaliy , Leshchuk Halyna
Published: November 2023

The article updates the problem of forming the professional communicative competence of medical profile specialists in the conditions of the complication of socio-professional interactions due to the deepening of social isolation caused by the COVID pandemic, the need to provide medical care in emergency situations (war, technological and environmental disasters, etc.). It is emphasized that the mentioned processes are accompanied by an increase in the risks of emotional burnout and conflict in the professional activities of medical profile specialist, the need to act quickly in extreme situations and make vital decisions, which increases the urgency of the issue of the readiness of professionals for effective, partly crisis communication, which in the medical field has be characterized by timeliness, accuracy, completeness and an unambiguous understanding of a specific medical situation. Modern approaches to the interpretation of the concept of «communicative competence» both as a universal concept and taking into account the specifics of the professional activity of medical profile specialists are analyzed. It was found that communicative competence is a system of knowledge, abilities and skills of an individual that ensure effective interpersonal interaction, and includes: speech, discursive, sociolinguistic, illocutionary, strategic,  linguistic and intercultural competence. It is noted that the communicative competence of a medical profile specialist presupposes the formation of contact skills, readiness to collect and analyze information, plan and convey to the patient the essence of diagnostic and treatment procedures, completion of communication, structuring of a communicative act, the ability to use various communication mechanisms in order to ensure a therapeutic effect on the patient. It was concluded that a high level of communicative competence of medical professionals determines the effectiveness of providing medical services in general, promotes understanding between all subjects of the medical care process, increases the patient's trust in the medical professional, avoids unnecessary conflicts and delays in the treatment process, etc.
A family study assessing P300 as a probable electrophysiological endophenotype in obsessive-compulsive disorder
Authors: Khanande Roshan , Nizamie S. Haque , Das Basudeb , Goyal Nishant , Tikka Sai Krishna , Mehta Varun , Sachacher Bhoomika , Motichand Sandeep , Katshu Mohammad Zia Ul Haq , Abhishek Priyadarshee
Published: November 2023

Objectives:

Endophenotype models of disease would help to clarify both diagnostic classification and etiological understanding of obsessive-compulsive disorder (OCD). The objective of the study is to investigate electrophysiological endophenotypes in OCD.

Material and Methods:

We recorded P300 on an auditory oddball paradigm for 20 patients with OCD, their 20 first-degree relatives (FDRs), and 20 normal controls (matched with patients). Patients were assessed on the Yale-Brown Obsessive-Compulsive Scale, Hamilton Rating Scale for Anxiety, and Hamilton Rating Scale for Depression.

Results:

Both patients and FDRs had significantly shorter P300 latencies as compared to normal controls in all regions assessed (P < 0.01). Significantly smaller centro-parietal (P < 0.01) P300 amplitude on auditory oddball paradigm was found in patients and FDRs as compared to normal controls.

Conclusion:

Shorter P300 latency representing increased processing speed and smaller P300 amplitude reflective of dysfunctional response inhibition are suggested to mediate genetic risk for OCD and proposed as possible electrophysiological endophenotypes for OCD.
Molecular Cloning and Expression Analysis of CONSTANS-LIKE 2 in Mucuna bracteata in Different Tissues and at Low Temperature
Authors: Misfahulhairah Shariff , Parameswari Namasivayam , Mohd-Yusoff Nur Fatihah
Published: November 2023

Mucuna bracteata is a leguminous cover crop that is planted in Malaysian oil palm and rubber plantations. This legume can grow well locally but is unable to produce flowers. Non-flowering M. bracteata plants presumably do not perceive the flowering signals to initiate the reproductive phase due to environmental differences. This study is on cloning a putative flowering gene, CONSTANS-LIKE 2 (COL2), from leaves of M. bracteata. To understand the molecular regulation of this gene in locally grown M. bracteata, we analysed its expression profile in different tissues of M. bracteata seedlings and response to low temperature using real-time polymerase chain reaction. The MbCOL2 gene was identified to be expressed in all selected tissues; leaf, terminal bud and stem of 2 months, 6 months and 12 months-old seedlings in different patterns. The MbCOL2 expression was the highest in the leaf tissue. Meanwhile, the expression of MbCOL2 was increased due to the low temperature. Physicochemical properties of MbCOL2 and its orthologues were also defined to analyse their protein functional properties. Outputs from this study can assist to better understand the molecular regulation of growth and development in M. bracteata.
Role of lens and dormancy breaking treatment in Fabaceae seeds (Acacia auriculiformis A.Cunn. ex Benth., Delonix regia (Bojer ex Hook.) Raf. Cassia fistula L., Samanea saman (Jacq.) Merr., Pongamia pinnata L.)
Authors: Praticia Preethi Jenifer S. , Krishnaveni C. , Kanchana M.
Published: November 2023

Seeds of leguminous plants are generally considered as orthodox seed. However, the conditions for combinations of dormancy, as well as the location of water gaps in Fabaceae seeds remain unclear. In the present study, we consider the adaptive role of impermeable coats in the seeds of Acacia auriculiformis A.Cunn. ex Benth., Delonix regia (Bojer ex Hook.) Raf. Cassia fistula L., Samanea saman (Jacq.) Merr., Pongamia pinnata L. The study was specially designed to analyze the condition that broke physical dormancy and locating primary water gap during dormancy breaking. Seeds were treated in hot water to break its physical dormancy and it was observed that water entered only through the lens due to dislodgement of palisade layer. In addition to extension of storage life of Delonix regia seed, it was proved by analyzing the low moisture content of 5.31%. This study concludes that the impermeable seed coat of seeds with low moisture content will increases storage life and seed imbibition adjusts germination with the growing season.
In vivo study for Therapeutic Potential of Bioactive Compounds from Curcuma longa and Tinospora cordifolia against Pulmonary Fibrosis
Authors: Annam Naga Lakshmi , Venkateswarulu T.C. , Krupanidhi S.
Published: November 2023

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with no known cause. It is a severe condition characterized by the accumulation of excessive extracellular matrix (ECM) in the lungs, leading to difficulty in oxygen intake. In this study, the researchers aimed to investigate the potential therapeutic effects of Curcuma longa and Tinospora cordifolia extracts in a mouse model of bleomycin-induced pulmonary fibrosis. The mice were divided into groups and treated with either the extracts, pirfenidone (a commonly used IPF treatment), or a control. The effects of these treatments on lung edema, body weight, antioxidant enzyme activity, collagen content and myeloperoxidase (MPO) activity were assessed. The results showed that treatment with the extracts and pirfenidone led to improvements in lung edema and body weight compared to the bleomycin group. The extracts also exhibited antioxidant and anti-inflammatory effects by increasing the activity of catalase and superoxide dismutase enzymes while reducing MPO activity. Furthermore, the extracts reduced collagen content, indicating a potential anti-fibrotic effect. Histological analysis of lung tissue confirmed the beneficial effects of the extracts, showing reduced lung damage, inflammatory cell infiltration and collagen deposition. These findings suggest that Curcuma longa and Tinospora cordifolia extracts may have therapeutic potential in treating IPF. In conclusion, this study demonstrates the potential anti-fibrotic and anti-inflammatory effects of Curcuma longa and Tinospora cordifolia extracts in a bleomycin-induced mouse model of pulmonary fibrosis. Further research is warranted to elucidate the underlying mechanisms and to determine their efficacy in human IPF patients. These findings highlight the potential of traditional medicines as alternative or complementary treatments for IPF, offering advantages such as long-term duration, low adverse effects and stable therapeutic impact.
Phytochemical Screening and in vitro Studies on Anti-urolithiatic Activity of Sesbania grandiflora (L.) Root Extract
Authors: Sivaranjani V. , Parthiban P.
Published: November 2023

Plant-based drugs have long been used worldwide as traditional medicines for treating various ailments. This study evaluated the in vitro anti-urolithiatic activity of Sesbania grandiflora root extract. In addition, the phytochemical characterization of aqueous and ethanolic extract of Sesbania grandiflora root was also carried out. Phytochemicals such as tannin, saponins, flavonoids, steroids, terpenoids, triterpenoids, polyphenol, glycoside and anthraquinone are present in both aqueous and ethanolic extract of Sesbania grandiflora root extract, while alkaloids were absent in aqueous extract and anthocyanins were absent in ethanolic extract. Of note, significant amounts of flavonoids, terpenoids and total phenol were found in Sesbania grandiflora root extract. Histochemical analysis further confirmed the presence of these phytochemicals. In vitro studies confirm that Sesbania grandiflora root extract exhibited a potent anti-urolithiatic activity.
Genome Stability Profiles of Titania Nanosurface Technology for Biomedical Applications
Authors: S.M.N. Mydin Rabiatul Basria , Wan Eddis Effendy Wan Nuramiera Faznie , Qaid Qazem Ekhlas , Hazan Roshasnorlyza , Sreekantan Srimala
Published: November 2023

The emergence of nano-based products for advanced biomedical applications has underlined the need for toxicogenomic studies which govern genome stability endpoints. In the present study, the genome stability profiles on cell-TNA interaction were assessed via nuclear staining profile by a fluorescent microscope, DNA ploidy profile by flow-cytometry, metaphase chromosome analysis, DNA topoisomerase II alpha (TOP2A) profiling by chromogenic in situ hybridization (CISH), cytokinesis-blocked micronucleus assay (CBMN), reactive oxygen species (ROS) measurement and gene expression profile by real-time polymerase chain reaction (RT-PCR). Findings from this study demonstrated that no significant genomic instability risk was observed from cell-TNA interaction, especially at clastogenic and aneugenic levels. Findings also suggest that cell-TNA interaction could involve the regulation of ribonucleoprotein complex and cell metabolism associated with the cellular adaptation process towards the nanosurface. Further comprehensive studies involving in vivo models are needed to support this work.
Human Centromere associated protein (CENP-A, B, S, N, E) binding potentials of Nitrile compounds: An in silico study
Authors: Duda Madhavi Latha , Velidandi Amarnath , Gurram Shyam Prasad
Published: November 2023

In the present investigation, different nitrile compounds synthesized earlier using one pot synthesis method were studied for Human Centromere Protein (CENP’s) binding potentials in silico so as to treat different types of cancers. An advanced auto dock 4.2 version was used for the study. Among 12 nitrile compounds studied, compound 2 (4-chloro,3cyano cumarin) and compound 11 (2-nitrile chromone) exhibited highest binding affinity to CENP-A,B,S and E proteins while rest of the nitrile compounds under study showed moderate degree of binding to CENP’s. Among 4.0 proteins studied, highest biding affinity of the compound 2 and 11 was recorded with protein A followed by B and E while least binding of the nitrile compounds was found to the protein S. Hence, from the above results viz. binding scores, hydrogen bond, Van der waals interactions of the nitrile compounds with the CENP’s, it can be concluded that the compounds 2 and 11 have the potential to develop as drugs for treating cancers targeting CENP proteins. However, further in vitro and in vivo investigations are required to develop as final drug.
Applying Large Graph Neural Networks to Predict Transition Metal Complex Energies Using the tmQM_wB97MV Dataset
Authors: Garrison Aaron , Heras-Domingo Javier , Kitchin John , Gomes Gabriel , Ulissi Zachary , Blau Samuel
Published: November 2023

Machine learning (ML) methods have shown promise for discovering novel catalysts, but are often restricted to specific chemical domains. Generalizable ML models require large and diverse training datasets, which exist for heterogeneous catalysis but not for homogeneous catalysis. The tmQM dataset, which contains properties of 86,665 transition metal complexes calculated at the TPSSh/def2-SVP level of density functional theory (DFT), provided a promising training dataset for homogeneous catalyst systems. However, we find that ML models trained on tmQM consistently underpredict the energies of a chemically distinct subset of the data. To address this, we present the tmQM_wB97MV dataset, which filters out several structures in tmQM found to be missing hydrogens and recomputes the energies of all other structures at the wB97M-V/def2-SVPD level of DFT. ML models trained on tmQM_wB97MV show no pattern of consistently incorrect predictions and much lower errors than those trained on tmQM. The ML models tested on tmQM_wB97MV were, from best to worst, GemNet-T > PaiNN ~ SpinConv > SchNet. Performance consistently improves when using only neutral structures instead of the entire dataset. However, while models saturate with only neutral structures, more data continues to improve the models when including charged species, indicating the importance of accurately capturing a range of oxidation states in future data generation and model development. Furthermore, a fine-tuning approach where weights were initialized from models trained on OC20 led to drastic improvements in model performance, indicating transferability between ML strategies of heterogeneous and homogeneous systems.
From MS/MS Library Implementation to Molecular Networks: Exploring Oxylipin Diversity with NEO-MSMS
Authors: Elloumi Anis , Mas-Normand Lindsay , Bride Jamie , Reversat Guillaume , Bultel-Poncé Valérie , Guy Alexandre , Oger Camille , Demion Marie , Le Guennec Jean-Yves , Durand Thierry , Vigor Claire , Sánchez-Illana Ángel , Galano Jean-Marie
Published: November 2023

Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids (PUFAs), serve as biomarkers for many diseases and play crucial roles in human physiology and inflammation. Despite their significance, many non-enzymatic oxygenated metabolites of PUFAs (NEO-PUFAs) remain poorly reported, resulting in a lack of public datasets of experimental data and limiting their dereplication in further studies. To overcome this limitation, we constructed a high-resolution tandem mass spectrometry (MS/MS) database comprising pure NEO-PUFAs (both commercial and self-synthesized) and in vitro free radical-induced oxidation of diverse PUFAs. By employing molecular networking techniques with this database and the existent ones in public repositories, we successfully mapped a wide range of NEO-PUFAs, expanding the strategies for annotating oxylipins, and NEO-PUFAs and offering a novel workflow for profiling these molecules in biological samples.
On the hunt for metalloenzyme inhibitors: Investigating the Presence of Metal-Chelating Compounds in Screening Libraries and Chemical Spaces
Authors: Schuck Bruna , Brenk Ruth
Published: November 2023

Metalloenzymes play vital roles in various biological processes, requiring the search for inhibitors to develop treatment option for diverse diseases. While screening compound libraries is a conventional approach, exploring virtual chemical spaces housing trillions of compounds has emerged as an alternative strategy. In this study, we investigated the suitability of selected screening libraries and chemical spaces for discovering inhibitors of metalloenzymes featuring common ions (Mg2+, Mn2+, and Zn2+). First, metal-chelating groups from ligands interacting with ions in the Protein Data Bank (PDB) were extracted. Subsequently, the prevalence of these groups in two focused screening libraries (Life Chemicals' chelator library, comprising 6,428 compounds, and Otava's chelator fragment library, with 1,784 fragments) as well as two chemical spaces (GalaXi, and REAL space, containing billions of virtual products) was investigated. In total, 1,223 metal-chelating groups were identified, with about a quarter of these groups found within the examined libraries and spaces. Our results indicate that these can serve as valuable starting points for drug discovery targeting metalloenzymes. Additionally, this study suggests ways to improve libraries and spaces for better success in finding potential inhibitors for metalloenzymes.