bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of polymorphism of platelet receptors genes P2RY12, ITGB3 and CYP2C19 cytochrome metabolizer enzyme on the platelet activity and efficiency of clopidogrel in patients with stable stenocardia in the Grodno region
Authors: Pronko T. P. , Snezhitskiy V. A. , Gorchakova O. V. , Stepuro T. L. , Gladkiy M. L.
Published: June 2021

The aim of the study was to assess the distribution of polymorphic variants G681A of the CYP2C19 gene, H1/H2 of the P2RY12 gene, and T1565C of the ITGB3 gene and to study their effect on the platelet activity and clopidogrel efficacy in patients with stable stenocardia living in the Grodno region. The study included 92 patients with stable stenocardia, 89 of them underwent elective percutaneous coronary intervention (PCI), and 93 practically healthy people. The survey data (general clinical, aggregometry, general blood count and platelet indices, and polymerase chain reaction genotyping) were analyzed using the STATISTICA 10.0 software.A high prevalence of carriage of genotypes associated with possible variability in response to clopidogrel therapy was revealed both among patients with stable stenocardia and among practically healthy individuals in the Grodno region. The frequency of occurrence of studying genotypes among patients with stable stanocardia was 23.9 % for the CYP2C19 gene (polymorphic locus G681A), 40.2 % for the P2RY12 gene (polymorphic locus H1/H2), and 31.5 % for the gene ITGB3 (polymorphic locus T1565C). For the group of practically healthy individuals, the distribution of these genotypes was 18.3; 46.2; 37.6 %, respectively. Associations were revealed between the carriage of the 681A allele of the CYP2C19 gene and the H2 haplotype of the P2RY12 gene with high residual platelet reactivity during clopidogrel therapy in patients with stable stenocardia. An association was found between the carriage of the H2 haplotype of the H1/H2 polymorphism of the P2RY12 gene with high platelet MPV values and a higher frequency of large platelets (P-LCR) in patients with stable stenocardia.
Anti-inflammatory properties of the combination of meloxicam and N-acetyl-L-proline
Authors: Vauchok A. U. , Dubovik B. V.
Published: June 2021

The anti-inflammatory properties of the combination of meloxicam and atypical NSAID N-acetyl-L-proline (Groceprol®) after intragastric administration in a model of carrageenan paw edema in mice were studied. The average effective dose of N-acetyl-L-proline calculated by the regression analysis method in this model was 414 mg/kg, and the average effective dose of meloxicam was 2.85 mg/kg. In the combination in a ratio of 40:1, the activity of the compounds increases significantly, the ED50 of meloxicam decreases to 1 mg/kg, a similar value of N-acetyl-L-proline becomes 43 mg/kg. The same trend was also observed with another mass ratio of components of 20:1. The analysis of the pharmacodynamics of the combination of drugs according to the T. Chou method showed an additive type of interaction, typical for compounds with different mechanisms of primary action. It was established that a combination of N-acetyl-L-proline and meloxicam in the weight ratios of 40:1 and 20:1 demonstrate synergism, allowing to reduce the dose of the components in 2.7–9.6 times as compared with the effect of the drugs individually.The results of the study are the experimental justification for the use of anti-inflammatory synergistic combination of N-acetyl-L-proline and meloxicam.
SIGNIFIKANSI PENGEMBANGAN INDIKATOR PERTANIAN BERKELANJUTAN UNTUK MENGEVALUASI KINERJA PEMBANGUNAN PERTANIAN INDONESIA
Authors: Mucharam Iim , Rustiadi Ernan , Fauzi Akhmad , Harianto
Published: June 2021

Pertanian berkelanjutan merupakan komponen penting dalam pencapaian Sustainable Development Goals (SDGs). Pengukuran keberlanjutan pertanian mutlak dilakukan untuk lebih memahami kondisi saat ini, mengidentifikasi tren, menetapkan target, memantau kemajuan, dan membandingkan kinerja antar wilayah. Penelitian tentang keberlanjutan pertanian di Indonesia lebih banyak dilakukan pada level usaha tani atau lokal. Indonesia belum memiliki indikator pertanian berkelanjutan yang menjadi tolok ukur penilaian pertanian berkelanjutan pada level regional/provinsi/nasional. Hal ini disebabkan karena begitu kompleksnya penilaian yang perlu dilakukan untuk mendapatkan hasil yang baik untuk penilaian pada level regional dan nasional. Indikator yang dapat diukur mengenai kelestarian lingkungan pertanian, dengan tujuan meminimalkan dampak lingkungan dari pertanian, merupakan alat penting untuk membantu menggerakkan dunia menuju masa depan pangan yang berkelanjutan. Indikator memungkinkan pembuat kebijakan, petani, bisnis, dan masyarakat sipil untuk lebih memahami kondisi saat ini, mengidentifikasi trend, menetapkan target, memantau kemajuan, dan membandingkan kinerja antar wilayah dan negara.
PENGGUNAAN APLIKASI KASIR PINTAR DALAM PENCATATAN KEUANGAN (STUDI KASUS UMKM POKLAHSAR WISNA FRESH)
Authors: Dewi Pratiwi Kartika , Safitry Silvya Eka , Mustoffa Ardyan Firdausi
Published: June 2021

Research in this community service program is carried out to help owners solve problems, namely the entry and exit of sold products, recording inventory of ready-to-sell products, and the amount of profit earned from sales. So far, the owner's recording is still very simple and doesn't even keep records at all. Taking this topic aims to help make it easier for the owner as a business actor to control the sales of their products and to help the owner to make it easier to find out the amount of profit earned from sales. In using the Smart Cashier application, it can make it easier to check the amount of inventory, find out the amount of production, the number of products sold, and the profit earned from sales. The results of using the Smart Cashier application help the owner check the amount of inventory, find out the number of products sold, the profit earned from sales, and print sales receipts
PENGEMBANGAN UMKM BERBASIS INOVASI PRODUK DAN E-COMMERCE DI DESA WANGON BANYUMAS
Authors: Saputra Endra , Inayati Nur Isna , Hartikasari Annisa Ilma
Published: June 2021

The management of new products is a form of innovation that boosts the economy of the local area and even the state. Empowerment of the social community through the MSME development approach through community groups will have a positive impact on village development, especially in Wangon Village, Banyumas Regency. The thing that underlies this service is the existence of a superior commodity in the village of Wangon, namely in the form of brown sugar which can be used as a new product that can increase local income. The problems faced by the community are the absence of modern technology that accelerates the production process as well as bookkeeping and marketing that can add to the production process and smooth production.
The Effect of Stirring Speeds to the Entrapment Efficiency in a Nanoparticles Formulation of Java Plumâ€™s seed Ethanol Extract (Syzygium cumini)
Authors: Supraba Widayanti , Juliantoni Yohanes , Ananto Agus Dwi
Published: June 2021

Java Plumâ€™s (Syzygium cumini) seed contains flavonoids in the form of quercetin. Quercetin plays an essential role in stimulating insulin production from pancreatic beta cells. However, it could be easily degraded by gastric acid or the digestive system. Thus, in this research, a good delivery system for quercetin will be established, namely nanoparticles. The study objectives are determining the entrapment efficiencyâ€™s percentage of nanoparticle preparations from ethanol extracts of Java Plumâ€™s seeds as well as observing the effect of stirring speed on the percentage of entrapment efficiency. Java Plumâ€™s seed extract was obtained by maceration method using ethanol 70% with the ratio between the simplicial powder and solvent is 1 : 4 respectively. Meanwhile, the solvent evaporation process was undergone by using a water bath with temperature not exceeding 70Â°C. The nanoparticle formulation of Java Plumâ€™s seed extract was made by adding polymers in the form of chitosan and sodium tripolyphosphate cross-linker with three variations of stirring speed (500, 1000, and 1500 rpm) using a magnetic stirrer. The percentage of entrapment efficiency was obtained by subtracting the flavonoids levels of Java Plumâ€™s seeds extract and flavonoids levels of Java Plumâ€™s seeds extract in nanoparticles. Then, the value was divided by flavonoids levels of Java Plumâ€™s seeds extract and multiplied by 100%. Quercetin levels obtained by absorbance readings using spectrophotometry UV-Visible, then absorbance value added into variable X on equation quercetinâ€™s standard curve y = 0,0229x + 0,0644. The results show that the percentage of entrapment efficiency at speed variations of 500, 1000, and 1500 rpm are 48.8459%, 49.1064%, and 56.0413% respectively. According to the t-test two independent samples statistical test, the data has a 0.961 probability value (500 rpm vs 1000 rpm), 0.324 probability value (1000 rpm vs 1500 rpm), 0.25 (500 rpm vs 1500 rpm). Probability value > 0.05, which means the stirring speed does not significantly influence the percentage of entrapment efficiency.
Detection of Mercury Ions in Water using a Plastic Optical Fiber Sensor
Authors: Hardiantho Willy , Arminah Bidayatul , Arifin Arifin
Published: June 2021

Research has been carried out on the detection of mercury ions in water using plastic optical fibers. Detection of mercury ions is done by immersing the optical fiber sensor in the HgCl2 solution, where both ends of the sensor are connected to LED and phototransistor. LED as a light source will emit light along with the optical fiber which will be received by the phototransistor. The optical light received by the phototransistor is converted into an electric voltage and given again in the differential amplifier. The output voltage in the form of an analog signal is converted into a digital signal on the Arduino UNO to be read on a computer. The optical fiber as a sensor is made in two configurations, namely U configuration and spiral spring configuration. The jacket and the fiber optic cladding are peeled off and then covered with chitosan. Each configuration will be given a variation of the curve to analyze the characteristics of the sensor. The curvature can cause a large power loss resulting in attenuation of the light intensity of the LED received by the phototransistor. Apart from the effect of indentation on optical fibers, the output voltage measurement results are also influenced by the level of HgCl2 concentration. The best measurement results for mercury ion sensors in water using plastic optical fibers are obtained in a spiral spring configuration with a chitosan cladding with a variation of 6 coils a sensitivity of 104.065 mV/ppm.
The V-RAMP program: Building research administration and management capacity in Nigeria
Authors: Aliyu Muktar H. , Iliyasu Zubairu , Ingles Donna J. , Cassell Holly M. , Lloyd Wendy H. , Ahonkhai Aima A. , Abdu Aliyu , Audet Carolyn M. , Wester C. William
Published: June 2021

The increasing volume and complexity of research activities in Nigeria necessitates urgent measures to improve research infrastructure in grants administration and management. The Vanderbilt-Nigeria Research Administration and Management Training Program (V-RAMP) seeks to build infrastructure capacity in research administration and management and research ethics at a major teaching hospital in Nigeria. We will perform a mixed methods needs assessment of the administrative and management environment and develop an action plan to address infrastructure needs, prioritize processes, and guide program implementation. We will capacitate a newly established Office of Research Administration and improve the knowledge and skills of research administrators and grant managers via short term in-person trainings in Nashville, Tennessee and in Kano, Nigeria and through remote learning opportunities. We will enhance local administrative efficiency and performance of research ethics operations through training and mentoring of members and staff of the ethics review committee. Systematic processes to streamline protocols, including a Research Electronic Data Capture (REDCap) protocol tracking database and standard operating procedures in the responsible conduct of research and rigor and reproducibility will also be developed. V-RAMP will enable the creation of a high-quality research administration environment that is knowledgeable, efficient, and compliant regarding the fiscal, management and ethical standards of sponsored research.
Transcendental Knowability and A Priori Luminosity
Authors: Stephenson Andrew
Published: June 2021

This paper draws out and connects two neglected issues in Kant’s conception of a priori knowledge. Both concern topics that have been central to contemporary epistemology and to formal epistemology in particular: knowability and luminosity. Does Kant commit to some form of knowability principle according to which certain necessary truths are in principle knowable to beings like us? Does Kant commit to some form of luminosity principle according to which, if a subject knows a priori, then they can know that they know a priori? I defend affirmative answers to both of these questions, and by considering the special kind of modality involved in Kant’s conceptions of possible experience and the essential completability of metaphysics, I argue that his combination of knowability and luminosity principles leads Kant into difficulty.
Students’ Perception of Online Learning During Covid-19: An Evidence from University of Muhammadiyah Banda Aceh, Indonesia
Authors: Safura Siti
Published: June 2021

The pandemic of Coronavirus has influenced all levels of education in the whole world. This impact forces the Ministry of Education to switch from traditional education to online education. As a result, educators must run this policy to teach the classroom and students must adapt to this situation. This research aimed to find out students’ perception of online learning during the Coronavirus pandemic. This research employed the qualitative design and used the survey method to distribute the questionnaires. The object of this research was twenty-seven students of the English Department, University of Muhammadiyah Aceh. The obtained data was analyzed through descriptive analysis to see how online class is perceived by students during the pandemic. The result of this research shows that the students share the positive perceptions toward online learning during the Coronavirus pandemic. The finding also displays the hesitation of students in deciding the problem faced in having the online class.
The Comparison of Students’ Perceived Levels of Self-Efficacy in Live, Online and Live Online Courses
Authors: Wangwongwiroj Tarosh , Yasri Pratchayapong
Published: June 2021

Education during COVID-19 pandemic has been greatly disrupted. While live courses where students meet face-to-face in classrooms are physically limited, online courses become more popular where students learn from pre-recorded videos at their own pace. In contrast, live online courses are learning modes where students and teachers meet via webinar tools such as zoom, skype, google meet, webex, teams, to name a few. This study compared students’ perceived levels of self-efficacy in these three different settings. Self-efficacy is defined as belief in one’s own ability to accomplish a task, which can be influenced by mastery experiences, verbal persuasion, vicarious experiences, and physiological states. An online questionnaire with 12 closed-ended statements based on a 5-Likert scale was developed, representing the four factors in the three modes of learning. A total of 105 voluntary responses were received. Statistical differences in the mean scores were determined by a paired sample t-test. The results at the significance level of 95% showed that the mean score of mastery experiences was the greatest in live courses (4.5), followed by live online (4.4) and online courses (3.3). The same was observed in vicarious experiences where live courses gained the greatest mean (4.5), followed by live online (4.3) and online courses (1.7). The means of verbal persuasion between live (4.5) and live online courses (4.3) did not differ significantly, but the lowest was in online courses (1.6). Interestingly, the reverse trend was found in psychological states in which the greatest was found in online (4.7), followed by live online (4.5) and live courses (3.6). The analysis above was based upon students who had no technical difficulties to access live online courses. However, this may not be applicable to contexts where internet connect is problematic. For educational implications, the findings revealed that live online courses are proven to be the most appropriate mode of learning during the pandemic. In contrast, online courses are associated with lower levels of mastery experiences, vicarious experiences, and verbal persuasion perceived by learners; whereas live courses lowered psychological states.
Climate and environmental context of the Mongol invasion of Syria and defeat at ‘Ayn Jālūt (1258–1260 CE)
Authors: Di Cosmo Nicola , Wagner Sebastian , Büntgen Ulf
Published: June 2021

After a successful conquest of large parts of Syria in 1258 and 1259 CE, the Mongol army lost the battle of 'Ayn Jālūt against Mamluks on September 3, 1260 CE. Recognized as a turning point in world history, their sudden defeat triggered the reconfiguration of strategic alliances and geopolitical power not only in the Middle East, but also across much of Eurasia. Despite decades of research, scholars have not yet reached consensus over the causes of the Mongol reverse. Here, we revisit previous arguments in light of climate and environmental changes in the aftermath of one the largest volcanic forcings in the past 2500 years, the Samalas eruption ~1257 CE. Regional tree ring-based climate reconstructions and state-of-the-art Earth System Model simulations reveal cooler and wetter conditions from spring 1258 to autumn 1259 CE for the eastern Mediterranean/Arabian region. We therefore hypothesize that the post-Samalas climate anomaly and associated environmental variability affected an estimated 120,000 Mongol soldiers and up to half a million of their horses during the conquest. More specifically, we argue that colder and wetter climates in 1258 and 1259 CE, while complicating and slowing the campaign in certain areas, such as the mountainous regions in the Caucasus and Anatolia, also facilitated the assault on Syria between January and March 1260. A return to warmer and dryer conditions in the summer of 1260 CE, however, likely reduced the regional carrying capacity and may therefore have forced a mass withdrawal of the Mongols from the region that contributed to the Mamluks’ victory. In pointing to a distinct environmental dependency of the Mongols, we offer a new explanation of their defeat at 'Ayn Jālūt, which effectively halted the further expansion of the largest ever land-based empire.
Sosyal Bilimlerde Büyük Veri Üzerine Yapılan Akademik Çalışmaların Analizi: YÖK Tez Örneği (2010 - 2020)
Authors: BÖLÜKBAŞ Kenan
Published: June 2021

Bilim, gözlem ve deneylere dayanan, sosyal ve beşeri süreçleri bünyesinde barındıran süreçler bütünü olarak nitelendirilebilir. Günümüzde, teknolojinin gelişmesiyle birlikte bilime entegre olan sistemlerin karmaşık, dijital ve çok yönlü bir yapıda olduğunu söylemek mümkündür. Bu sistemlerden biri de son dönemde daha da popüler hale gelen “büyük veri” (big data) kavramıdır. Henüz işlenmemiş, analiz edilmemiş ve anlamlandırılmamış bir bilgi yığını olarak nitelenen büyük veri, kullanım amaçlarına göre önem kazanmaktadır. Son dönemlerde, özellikle sosyal medya kullanımının artmasıyla devasa bir bilgi havuzu ile karşımıza çıkmakta olan büyük veri kavramına, birçok kurum ve kuruluşun yanı sıra akademi dünyasının da ilgi gösterdiği söylenebilir. Bu çalışmada, büyük verinin akademik yazındaki durumu, ele alınış biçimleri, sosyal ve beşeri bilimler öncelenerek değerlendirilmiştir. Bu bağlamda sosyal bilimler alanında 2010 – 2020 yılları arasında yazılmış YÖK Tez doktora tezleri, örneklem olarak belirlenmiştir. Araştırmada, yöntem olarak nitel ve nicel içerik analizi kullanılmıştır. Elde edilen bulgular; yıllara, enstitülere ve anabilim dallarına göre tasnif edilmiş ve oransal dağılımlar sonucunda büyük veri ile ilgili tezler incelenmiştir. Sonuç olarak, literatürde büyük veri kavramının daha çok fen bilimleri alanında ele alındığı, sosyal bilimlerin ise ikinci planda kaldığı görülmüştür.
Nonlinear Integrodifferential Equations with Time Varying Delay
Authors: KUMAR Kamalendra , KARNATAK Manoj , KUMAR Rakesh
Published: June 2021

By practicing the manner of semigroup theory and Banach contraction theorem, the existence and uniqueness of mild and classical solutions of nonlinear integrodifferential equations with time varying delay in Banach spaces is showed. Certainly, an example is revealed to justify the abstract idea.

By practicing the manner of semigroup theory and Banach contraction theorem, the existence and uniqueness of mild and classical solutions of nonlinear integrodifferential equations with time varying delay in Banach spaces is showed. Certainly, an example is revealed to justify the abstract idea.
Konsep dasar ilmu gizi
Authors: AKVIANI SHARA
Published: June 2021

Ilmu Gizi (Nutrience Science) Ilmu yang mempelajari segala sesuatu tentang makanan dalam hubungannya dengan kesehatan optimal/ tubuh. Ilmu tentang makanan, zat-zat gizi, dan substansi yang terkandung didalamnya, peran dan keseimbangannya, untuk kesehatan dan masalah kesehatan. Ilmu yang menggunakan berbagai disiplin ilmu dasar, seperti biokimia, ilmu hayat (fisiologi), ilmu penyakit (patologi), dan beberapa ilmu lainnya. Jadi untuk menguasai bagian-bagian ilmu dasar tersebut yang relevan dengan kebutuhan ilmu gizi (Ahmad,2004).
Mind Map Value Propositions Design
Authors: Saputra Nicholas Jason
Published: June 2021

Mind Map Value Propositions Design
Septic shock and systemic inflammatory response syndrome patients' CD15+ granulocytes were subjected to global transcriptional profiling (SIRS)
Authors: P Rucha , S Vijay
Published: June 2021

In the United States, sepsis, the body's response to infection in a typically sterile circulation, is a leading causeof death (1). To assess the primary transcriptional alterations associated with each illness state, I utilized amicroarray data set from a cohort of thirtyone individuals with septic shock or systemic inflammatory responsesyndrome (2). At the transcriptional level, I discovered that the granulocytes of patients with SIRS weresimilar to those of patients with septic shock. SIRS showed a “intermediate” gene expression state betweenthat of control patients and that of septic shock patients for numerous genes expressed in the granulocyte. Thediscovery of the most differentially expressed genes in the granulocytic immune cells of patients with septicshock might aid the development of new therapies or diagnostics for an illness with a 14.7 percent to 29.9% inhospitaldeath rate despite decades of study (1).
UTILIZING KAHOOT APPLICATION IN ASSESSING FORMATIVE ASSESSMENT IN EFL CLASSROOM
Authors: Fernando Lucas
Published: June 2021

The principal reason for formative assessment is to improve understudies' learning and it ought to be viewed as a piece of the learning interaction. Game-based learning has gotten more normal in schooling and one of the arising game-based learning stages utilized in instruction establishments is Kahoot. This paper explored the impression of understudies towards Kahoot as a developmental evaluation instrument in school understudies in Indonesia. The examination utilized a review that comprises of 12 things through Kahoot study stage. An aggregate of 100 subjects partook in this examination. The understudies profoundly apparent Kahoot as fun, successful and better than e-learning stage for input as its middle score was 4. The remainder of things were acceptably seen by the understudies as demonstrated by the score of 3 aside from working on complex subjects that acquired an unsuitable level. There were critical middle score contrasts among male and female understudies for inspiration and saw information maintenance, whereby guys scored higher than females (p < 0.05). Kahoot is a promising developmental evaluation instrument that is achievable, down to earth and makes learning fun and pleasant. It very well may be utilized to spur understudies to learn. Be that as it may, Kahoot was not the best apparatus to work on complex subjects as seen by school understudies.
THE CUNEIFORM ORIGIN OF GENESIS AND A DATE FOR GENESIS 1
Authors: Harmer Carey Francis John
Published: June 2021

PART 1 argues for a paradigm shift to the conclusion that Genesis 1 to 37 was originally written in cuneiform; that Genesis 1–4 was written c. 2850 BC and Chapters 5 to 37 at about the time of the events recorded.PART 2 proposes a systematic transcription error due to misreading of the cuneiform signs, that reduces the ages of the patriarchs in Genesis 5 to a more likely range; if validated, confirming the thesis of PART 1. The proposed early dating is based on archaeological evidence without religious presuppositions; places the origin of the Judaeo-Christian world-view at the dawn of civilisation; and does not conflict with any scientific discovery or any Christian doctrine.PART 3 introduces a second paradigm shift, to the interpretation that Genesis 1 recounts Six Days not of Creation but of Revelation, signposting a path connecting Genesis 1 with current scientific knowledge, and with the origin of science.
Bone-related behaviours of captive chimpanzees (Pan troglodytes) during an excavating experiment
Authors: Rodrigo Alba Motes , Pickering Travis R. , Tennie Claudio , Hernandez-Aguilar R. Adriana
Published: June 2021

After stone tools, bone tools are the most abundant artefact type in the Early Pleistocene archaeological record. That said, they are still relatively scarce, limiting our understanding of the behaviors that led to their production and use. Observations of extant primates constitute a unique source of behavioural data with which to construct hypotheses about the potential uses of bone tools by our ancient hominin ancestors. In this study, we investigated the behavioural responses of two groups of captive chimpanzees (Pan troglodytes) (Ntotal=42) to the availability of isolated, disarticulated, defleshed, ungulate bones while participating in a foraging task aimed at eliciting excavating behavior involving those same bone specimens. Each chimpanzee group was provided with bone specimens of different characteristics and the two groups differed in their respective levels of experience with using tools to excavate (one group was mostly inexperienced while the other had ample experience utilizing sticks as excavating tools). We found that several individuals from the inexperienced group used the provided bone specimens as tools during the task. In contrast, none of the individuals from the experienced group used bones as excavating tools. Instead, these experienced chimpanzees performed other bone-related behaviours (not observed in the inexperienced group), such as hammering and extracting marrow with wooden tools. Given that previous experience in tool excavation did not predict the use of bones as tools in the excavating task, we hypothesize that the differences in behavior observed between the two chimpanzee groups were the result of the varying characteristics of the bones provided to each. Furthermore, our results suggest that it is the intrinsic characteristics of raw materials rather than the material itself that determines whether chimpanzees perceive an object as a suitable excavating tool.
KONSEP DASAR ILMU GIZI
Authors: Putri Awaliah Nirwana
Published: June 2021

Kata “gizi” berasal dari bahasa Arab ghidza, yg berarti “makanan”. Ilmu gizi bisa berkaitan dengan makanan dan tubuh manusia. Dalam bahasa Inggris, food menyatakan makanan, pangan dan bahan makanan.Pengertian gizi terbagi secara klasik dan masa sekarang yaitu:1.Secara Klasik : gizi hanya dihubungkan dengan kesehatan tubuh (menyediakan energi, membangun, memelihara jaringan tubuh, mengatur proses-proses kehidupan dalam tubuh).2.Sekarang : selain untuk kesehatan, juga dikaitkan dengan potensi ekonomi seseorang karena gizi berkaitan dengan perkembangan otak, kemampuan belajar, produktivitas kerja.
Konsep Dasar Ilmu Gizi
Authors: Gustiawan Didit
Published: June 2021

Konsep-konsep dasar ilmu gizi
A blood gene expression signature for epithelial ovarian cancer
Authors: S Vijay , P Rucha
Published: June 2021

In the industrialized world, epithelial ovarian cancer is the most fatal kind of gynecologic cancer1. A significant element in the mortality rate linked with epithelial ovarian cancer is late diagnosis2, which is caused by a lack of appropriate diagnostic and screening tools, such as the mammography in breast cancer. 3 and the prostate specific antigen (PSA) blood test, both of which are used to diagnose human prostate cancer. 4.5 Radiologic screening might be prohibitively expensive6. We explored previously published microarray data7 in order to identify genes expressed in the blood that may be used to differentiate individuals with epithelial ovarian cancer from those who were not. We found a core collection of 31 genes, ten of which satisfactorily differentiated control individuals from those with epithelial ovarian cancer on their own. Seven out of ten of these genes were also differently expressed in epithelial ovarian cancer tumor tissue8,9. These data may be used to construct a blood-based, quantitative PCR diagnostic screening method for the population-wide identification of epithelial ovarian cancer.
Konsep Dasar Ilmu Gizi
Authors: Ananda Amaliah Syarifah
Published: June 2021

Menjelaskan tentang konsep-konsep dasar ilmu gizi
Applied Interpolation for Musical Melodies Complementation and Filling
Authors: Marín Giraldo Simón , Osorio Juan Sebastián Díaz , González David Calle
Published: June 2021

Mathematics and music traditionally have been seen as very opposite areas of human development, one being rational and deterministic and the other more emotional and creative. A question that frequently arises is whether these two worlds can be joined in a certain manner, and that is what this work is about. Through the use of interpolation techniques we seek to generate functions for representing songs and thus determine new ways of musical improvisation which allow us to experience music not merely from the symmetry brought by the sounds themselves, but also from the rigour and accuracy of the mathematical and numerical methods.
Early farmers and their environment: archaeobotanical research at Neolithic and Chalcolithic sites in Jordan
Authors: Meadows John
Published: June 2021

PhD thesis written between 1998 and 2004 when I was a student at La Trobe University, Melbourne, Australia.
KONSEP DASAR ILMU GIZI
Authors: Nurain Salsabila
Published: June 2021

Ilmu gizi merupakan ilmu yang mempelajari zat- zat dari pangan yang bermanfaat bagi kesehatan dan proses yang terjadi sejak pangan dikonsumsi, dicerna, diserap hingga dimanfaatkan tubuh serta dampaknya terhadap pertumbuhan, perkembangan dan kelangsungan hidup. Ilmu gizi termasuk ilmu terapan yang berkaitan dengan berbagai ilmu dasar seperti: Ilmu Kimia, Biokimia, Biologi, Fisiologi, Pathologi, Ilmu Pangan dan lain- lain.
Digitalization of MSMEs as the Key to Economic Recovery during the Pandemic
Authors: Melani Olivia Erisa
Published: June 2021

Efforts were made by the state to restore its economy. MSMEs as an important asset and the driving wheel of the Indonesian economy, which also contributes significantly to the country's GDP, are almost entirely affected by this condition. Some small businesses are unable to survive, mostly due to lack of innovation, and involvement in digitization. There needs to be empowerment for each MSMEs as a step to strengthen the economy and increase competitiveness in domestic and international markets.
Mind Map Value Proposition Design
Authors: Kosasih Angelina Ginatasya
Published: June 2021

Mind Map Value Proposition Design
APPLYING KAHOOT IN FORMATIVE ASSESSMENT IN EFL CLASSROOM
Authors: Fernando Lucas
Published: June 2021

The standard defense developmental evaluation is to improve understudies' learning and it ought to be viewed as a piece of the learning affiliation. Game-based learning has gotten more normal in the coaching and one of the arising game-based learning stage utilized in direction establishments is Kahoot. This paper examined the impression of understudies towards Kahoot as a developmental evaluation instrument in school understudies in Indonesia. The evaluation utilized a review that contains 12 things through Kahoot study stage. An aggregate of 170 subjects took an interest in this appraisal. The understudies essentially clear Kahoot as fun, viable and better than e-learning stage for commitment as its middle score was 4. The remainder of things were acceptably seen by the understudies as demonstrated by the score of 3 next to managing complex subjects that acquired inadmissible level. There were essential focus score contrasts among male and female understudies for inspiration and saw information upkeep, whereby people scored higher than females (p < 0.05). Kahoot is a promising developmental evaluation instrument that is possible, objective and makes learning fun and beguiling. It very well may be utilized to nudge understudies to learn. Regardless, Kahoot was not the best contraption to manage complex subjects as seen by school understudies.
私のカレーの話と文化加算性
Authors: Le Tam-Tri
Published: June 2021

個人的なカレーの体験から文化価値の変化現象についての考えです。
Differing from diseased stage in melanoma, the olfactory receptor gene OR56A4 is expressed
Authors: S Vijay , P Rucha
Published: June 2021

We have compared the global profiles of 100 tumors in Stage I, II and III with two independently releasedmicroarray datasets in order to understand their transcriptional behaviors accompanying a progression in breastcancer (1, 2). The olfactive receptor, family 56, subfamily A, member 4 OR56A4, was discovered to have beenone of the genes with the most varied expression when comparing initial tumors in stage I, stage II, and stageIII of breast cancer patients. In the stage III tumors, OR56A4 expression in comparison to the stage I tumorswas lower.
“To have been forgiven by God and those I have wronged first”: A mixed methods study on self-forgiveness
Authors: Palmer Catherine , Bartlett James Edward
Published: June 2021

This pre-registered mixed methods study explored factors associated with self-forgiveness as previous research focused on the forgiveness of others from a quantitative perspective. A convenience sample of 102 participants (72% Christian) completed self-report scales including the Heartland Forgiveness Scale and the Perceptions of Forgiveness Scale. Additionally, participants completed four open questions on their own interpretations of forgiveness. We used multiple linear regression for quantitative data and thematic analysis for qualitative data. Divine forgiveness was a positive predictor, but religious commitment and perceived transgressions were negative predictors. Thematic analysis identified three themes: cognitive dissonance, conciliatory behavior, and God image. The findings suggest that subjective interpretations of religion may have an inhibiting role on an individual’s ability to self-forgive. Self-forgiveness appears dependent upon other inhibiting factors including God image, implicitly held virtues, and one’s understanding of forgiveness.
Reward accelerates the preparation of goal-directed actions
Authors: Adkins Tyler James , Lee Taraz
Published: June 2021

Sometimes our goals conflict with our habits, leading to impaired performance. Prior research shows that people are better at overcoming automatic responses and producing goal-directed responses when they are motivated by the prospect of reward. However, it is not known whether reward leads to improved performance via the inhibition of automatic responses, the facilitation of goal-directed responses, or a mixture of both. This is due in part to the fact that standard experimental paradigms used to study cognitive control rely on free response times. This allows participants to delay the initiation of their responses and avoid committing errors driven by prepotent response tendencies, making it difficult to infer how reward affects underlying cognitive processes. We addressed this limitation by using conflict tasks in which participants were forced to respond at a predetermined time. We manipulated the time available for response preparation by varying the onset of the target stimulus and we measured the participants' preparatory state at the time of the forced response. Finally, we used a probabilistic response preparation model that dissociates the preparation of habitual and goal-directed responses to infer the time required to prepare these different responses. Across two experiments, we found evidence that reward accelerated the preparation of goal-directed actions, while there was little evidence that reward further inhibited the preparation of automatic responses. This work sheds light on which cognitive control mechanisms are modulated by reward.
Effects of COVID-19-Related School Closures on Student Achievement—A Systematic Review
Authors: Hammerstein Svenja , König Christoph , Dreisoerner Thomas , Frey Andreas
Published: June 2021

The COVID-19 pandemic led to numerous governments deciding to close schools forseveral weeks in spring 2020. Empirical evidence on the impact of COVID-19-relatedschool closures on academic achievement is only just emerging. The present workaimed to provide a first systematic overview of evidence-based studies on generaland differential effects of COVID-19-related school closures in spring 2020 on studentachievement in primary and secondary education. Results indicate a negative effect ofschool closures on student achievement, specifically in younger students and studentsfrom families with low socioeconomic status. Moreover, certain measures can beidentified that might mitigate these negative effects. The findings are discussed in thecontext of their possible consequences for national educational policies when facingfuture school closures.
Psychological Distress and Perceived Discrimination Among Chinese International Students One Year into COVID-19: A Preregistered Comparative Study
Authors: Bi Kaiwen , Yeoh Desmond , Jiang Qiwenjing , Wienk Margaux Nicole Agnes , Chen Shuquan
Published: June 2021

Background and Objectives: During the COVID-19 pandemic, Chinese international students(CISs) experienced increased distress associated with a combination of unique and universal stressors, among which discrimination against Chinese is especially harmful. Therefore, studying correlates of distress among CISs, including the association between discrimination and distress and factors intensifying or attenuating this link, may yield important insights into prevention and intervention efforts.Design: We adopted a cross-sectional self-report design.Methods: Our study compared depression and anxiety between CISs (N = 381) and Chinese students in Chinese colleges (CSCCs; N = 306) and examined correlates of distress including the association between discrimination and distress as well as moderators on this link within CISs. Results: Compared to CSCCs, CISs reported greater depression and anxiety. Depression was associated with being female, older, non-heterosexual, increased discrimination, decreased self- esteem, coping flexibility, perceived social support, and satisfaction with online learning. Anxiety was associated with being female, heterosexual, in undergraduate years, increased discrimination, decreased self-esteem, subjective socioeconomic status, coping flexibility, and satisfaction with online learning. High perceived social support and being heterosexual weakened the association between discrimination and distress (anxiety and depression). Conclusions: Our study underscored the impact of the pandemic and related discrimination on CISs and highlighted individual differences that may warrant attention.
Personality by intelligence interaction effects on grades tend to be synergistic
Authors: Sorjonen Kimmo , Wallin Alma Sörberg , Falkstedt Daniel , Melin Bo
Published: June 2021

Earlier research has identified personality traits × intelligence interaction effects on academic performance. The present study, employing data from the 1997 National Longitudinal Survey of Youth (NLSY97, N = 8984), identified some interaction effects, mainly involving indicators of dependability, on high school grades. The interaction effects tended to be synergistic, meaning that the association between the trait and grades tended to strengthen with increased intelligence. This could be due to a sufficient level of intelligence being necessary for higher grades, and that lack thereof cannot be compensated for by a high degree of some advantageous personality trait. However, a positive association between intelligence and reliability in the measurement of personality, as well as a reversed causal effect of grades on self-rated personality moderated by intelligence, could also be contributing causes to the tendency for synergistic interaction effects.
Angemessenheit und Höflichkeit in der modernen Gesellschaft: Zwischen Individualisierung, Technisierung und Moralisierung
Authors: Youssef Ramy
Published: June 2021

Der Beitrag rekonstruiert das Problem angemessenen Verhaltens unter dem Gesichtspunkt, dass in der modernen Gesellschaft ein zunehmend anonymer und technisierter Sozialverkehr unter Berücksichtigung individueller Selbstdarstellungsbedürfnisse vollzogen werden muss. Höflichkeit, Freundlichkeit, Moralisierung oder Takt können die sich daraus ergebenden Widersprüche und Ambivalenzen (unter Inkaufnahme anderer Widersprüche und Ambivalenzen) zwar auflösen, erfordern jedoch in sehr unterschiedlichem Maße Personen- und Kontextwissen, riskante Eigeninitiativen und soziale Geschicklichkeit. Soziale Angemessenheit ist in der modernen Gesellschaft jedoch stets eine situations- und damit zufallsabhängige Größe. Sie lässt sich nicht (mehr) in Form eines gesellschaftlichen Zeremoniells programmieren, sondern kann nur individuell unter Berücksichtigung weniger technischer oder persönlicher Gesichtspunkte auf Kosten vieler anderer Aspekte erreicht werden – und bleibt damit als regulative Idee in der Praxis stets angreifbar.
The role of V.V. Dokuchaev in establishing soil ecology as a science of the biosphere class
Authors: Dergacheva Maria I.
Published: June 2021

The article examines the role of the outstanding scientist Vasily Vasilyevich Dokuchaev, whose 175th anniversary was March 1, 2021, in the development of soil ecology as a science of the biosphere class. The natural history methodology, which he introduced into scientific use, is discussed; the methodology was a milestone in the development of not only genetic soil science, but also all natural sciences.
Integrasi Kegiatan Masyarakat Budaya Lokal dan Lembaga dalam Pendidikan Toleransi
Authors: Mukhtar Jazuli , Yunus Yunus , Nugroho Ichwan
Published: June 2021

The research explains the form of local wisdom of Bugis culture as a cultural value that characterizes the Palopo people. The local wisdom developed in Palopo City is in line with the pluralistic Palopo culture developing in Indonesia. Palopo people has local wisdom values such as humanizing. These values are always preserved so that they become the glue of religious harmony in Palopo City. The type of this research is ethnography. The research findings show that knowledge and understanding of the cultural traditions of society that contain pluralism allow students to suspend suspicion or even wholly disappear negative things that students have understood about other religions. The concept of pluralism is seen from implementing the cultural philosophy in Palopo, namely Sipakatau, Sipakalebbi, and Sipakaingge. Two universities, IAIN Palopo and Andi Djemma University practice the local wisdom values. The results shows that personally, students who were actively involved in the implementation of local wisdom education felt that they had experienced significant changes. In the aspect of faith, they are increasingly convinced of their religion while still providing adequate space for a good and correct assessment of the truth of the teachings of other religious and cultural beliefs.
Effect of Alcornea cordifolia Aqueous and Methanolic Leaf Extracts against Antituberculosis Drugs Induced Liver Damage in Rats
Authors:   Pharmacology Department, Clinical and Therapeutic Pharmacy, University of Félix Houphouët-Boigny, Abidjan - Côte d'Ivoire, Kouakou Etienne Effo
Published: June 2021

The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with a high dose of paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent a risk factor for hepatotoxicity, could A. cordifolia play a key role to limit their hepatotoxicity? The objective of this study was to assess the histological changes of antituberculosis drugs in rat livers and their evolution after administration of an aqueous and a methanolic leaf extracts of A. cordifolia and therefore estimate their polyphenol and flavonoid contents. Rats were divided into three (3) groups: group 1 was treated with isoniazid; group 2 received the combination of isoniazid and rifampicin and group 3 was given the combination of isoniazid, rifampicin and pyraziamide. For each group of rats, the hepatotoxicant was either administered alone or two hours before administration of an aqueous (200, 400, or 800 mg/kg) or a methanolic (200, 400, or 800 mg/kg) leaf extracts of A. cordifolia each day for 10 days. Animals were sacrificed on day 11 and their livers removed for histolopathological analysis. In addition, total polyphenol and flavonoid contents were estimated in both extracts. Antituberculosis drug combinations caused peliosis lesions, steatosis and hepatocyte necrosis. The liver histology of rats that received extracts after administration of antituberculosis drug combinations showed the ability of extracts to annihilate or alleviate hepatocellular damage caused by such drugs. The methanolic extract, richer in total polyphenols (0.55 ± 0.02 mg EGA) than the aqueous extract (0.35 ± 0.01 mg EGA) demonstrated a greater hepatoprotective effect. Thus, according to liver histological analysis, the aqueous and methanolic leaf extracts of A. cordifolia could attenuate the hepatotoxicity induced by antituberculosis drugs in rats.
A Review on the Contemporary Status of Mutating Coronavirus and Comparative Literature Study of Current COVID-19 Vaccines
Authors:   Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Rajgir-803116, India, Jahangir M. Asadullah
Published: June 2021

The Novel corona virus was first reported in Wuhan province of China in the late 2019. It outspread rapidly which led to a new health crisis throughout the world by the beginning of March 2020 and was considered as a global epidemic. Several deteriorating health symptoms, morbidity and mortality were reported globally by WHO, with more than 34 lakh deaths being reported by 26 May 2021. Presently 16 vaccines are approved under emergency use in different countries and more than 33 vaccines are under phase 3 clinical trials and nearly 130 vaccines are in development phase. By the end of 2020 several new variants in U.K, South Africa, Brazil and India were reported which caused the second wave of COVID-19, for which new trials of vaccine are running to evaluate the efficacy and safety. Several technical problems are associated regarding the production, storing and supplying of these vaccines. For controlling the epidemic, the major challenge is to produce billions of vaccines and to make it available to the underdeveloped and poorer nations. This extensive review provides the details of the different variants of corona viruses reported in the different regions of the world, current vaccines approved under emergency use which are being administered throughout the globe, on-going and listed clinical trials on different vaccines under study for possible use in Covid-19 virus and future challenges associated with Covid-19 scenario.