bluuebunny/crossref_metadata_2025 huggingface dataset:
About terraces on the shore of the Teriberskaya Bay of the Barents Sea (the Kola Peninsula)
Authors: Neradovsky Yu. N. , Miroshnikova Ya. A. , Kompanchenko A. A. , Chernyavsky A. V.
Published: May 2022

The paper considers the results of the study of modern terraces on the coast of the Lodeyny Peninsula in the Barents Sea. According to field observations, decoding of space and geodetic maps and volumetric modeling, signs of three terraces have been identified. Two terraces having a rear seam, a cliff, a brow and horizontal platforms have been studied in more detail. The rear seams are located at 7 and 30 m, and the edges at 10 and 40 m above the sea level. The third terrace is confined to the level of 40-60 m, and has not been studied in detail. According to estimates, the first two terraces were formed about 3,300 and 6,000 years ago respectively. The 1st terrace characterizes the period of slow land rise by 10 m, at the speed up to 3 mm/year, which began about 3,300 years ago and continues to the present. It is characterized by a uniform sea retreat of about 15 mm/year. The erosion products of this terrace are common in the lateral zone and represent modern marine sediments, including beaches forming a new terrace. The 2nd terrace characterizes to the dynamics of rapid land rise by 30 m at a speed of about 11 mm/year, which occurred in the period from 6,000 to 3,300 years ago. The erosion products of this terrace are most common on the coast and are found at a distance of 100 m to 2-3 km from the shore. It is assumed that the speed of movement of the coastline during the retreat of the sea was different and reached up to 900 mm/year. According to the authors, preliminary data indicate the instability of the territory and the manifestation of block movements, which may have a negative impact on the development of infrastructure.
Zircon morphology and isotope U-Pb and Sm-Nd dating the rocks of the Kanozero alkaline granite massif (the Kola region)
Authors: Nitkina E. A. , Serov P. A.
Published: May 2022

The U-Pb dating zircon and Sm-Nd dating the whole rock and secondary minerals from the Kanozero massif of alkaline granites of the Kola region (the Fennoscandian shield) have been carried out. The age of alkaline granites of the Kanozero massif by zircon is 2667 ± 36 Ma, aplite-like alkaline granites - 2301 ± 13 Ma and blastomylonites - 2264 ± 12 Ma. The crystallization temperature of zircon has been estimated from the crystal habit. According to the zircon morphology of alkaline granites and blastomylonites the conditions during the crystallization process of the Kanozero massif have been established as long-term cooling high-temperature volatile- and alkali-rich crustal-mantle melts. The mineral Sm-Nd isochron by whole rock and by secondary minerals - biotite and titanite - has an age of 1921 ± 53 Ma interpreted as the time of regional Svecofene metamorphism. Based on the obtained isotopic data it can be noted that the rocks of the Kanozero massif of alkaline granites have similar features of formation and transformation with alkaline granites of the Keivsky terrane.
Numerical modeling of atmospheric pollution in the approaches of random selection of discrete dusting sites and interval distribution of dust size
Authors: Amosov P. V. , Baklanov A. A. , Makarov D. V. , Masloboev V. A.
Published: May 2022

The results of numerical simulation of atmospheric pollution in Apatity are presented with variations in the dusting area of discrete spatially spaced areas selected randomly and the wind flow velocity. CFD modeling in the volumetric formulation was performed using the COMSOL program. To calculate the aerodynamic characteristics, an incompressible fluid approximation was used using the standard ( k -ε) turbulence model. The process of fine dust propagation is modeled by numerical solution of the convective-diffusion impurity transfer equation taking into account the deposition rate. Numerical experiments (with a total number of more than 1,400) were carried out with a variation of the wind flow velocity from 5 to 23 m/s and a dusting area from 2 to 10 ha with a random selection of 20 discrete sites. Dynamic velocity distributions for specific areas of dusting, interval and total spatial distributions of dust pollution (dust particles with a diameter from 0 to 70 microns in increments of 10 microns) are obtained. The peculiarities of the influence on the levels of atmospheric pollution of specific areas of Apatity depending on the location of dusty areas on the surface of the beach of the tailings dump are noted. The calculated levels of atmospheric pollution in the center of Apatity averaged by the number of combinations of dusting sites are analyzed and generalized to functional dependencies. The calculated dependences of the dust concentration on the dusting area at a fixed wind speed are described by linear functions. The dependence of the dust concentration on the wind flow velocity at a fixed dusting area can be approximated by a power function. The generalized functional dependence makes it possible to predict the dust concentration in Apatity depending on the dusting area of randomly selected discrete areas on the surface of the tailings dump and the wind flow velocity. The obtained dependence permits to make a forecast of the critical dusting area at which the level of atmospheric pollution reaches the maximum permissible concentrations, depending on the speed of the wind flow.
Manifestaciones mucocutáneas en pacientes hospitalizados por COVID 19 en un hospital de alta complejidad
Authors: Jimenez Tamayo Sol Beatriz , Orozco-Jiménez Sara , González Correa Ana María
Published: May 2022

Introducción: el SARS-CoV-2 es un virus ARN de cadena simple que compromete diferentes órganos, incluyendo la piel. Los pacientes que cursan con este virus pueden presentar diferentes manifestaciones mucocutáneas. Objetivo: determinar la prevalencia de las lesiones mucocutáneas en pacientes hospitalizados por infección SARS-CoV-2/COVID 19 en el Hospital San Vicente Fundación Rionegro entre abril y junio del 2021. Materiales y métodos: estudio descriptivo transversal en pacientes hospitalizados con diagnóstico de infección por COVID-19 confirmado por pruebas serológicas y con lesiones mucocutáneas. Resultados: de 600 pacientes hospitalizados por COVID-19, 16 presentaron lesiones mucocutáneas para una prevalencia del 2,6%, y entre estos, 13 requirieron manejo en unidad de cuidados intensivos por síndrome de dificultad respiratoria aguda severa o enfermedad severa (81,25%) asociado a marcadores de mal pronóstico elevados. Los más elevados fueron la PCR, LDH o la presencia de linfopenia. Las lesiones vasculares fueron las más frecuentes (42,9%), que se manifestaron como púrpuras, vasculitis, livedo racemosa, perniosis y pseudoperniosis. Las erupciones o exantemas fueron de tipo maculopapulares (28,6%), eritematosas (19%) y urticariales (9,5%); además de úlceras en cavidad oral (8,8%) y vesículas (2,9%). El 75% de estos pacientes presentaron lesiones cutáneas en la fase activa de la enfermedad y el 25% en la fase resolutiva. Las morbilidades más frecuentes fueron hipertensión arterial (30%) y diabetes (20%). Seis pacientes fallecieron (37,5%). Conclusiones: las manifestaciones mucocutáneas asociadas al COVID-19, especialmente las de tipo vascular como las púrpuras, vasculitis y livedo racemosa, se asocian a formas graves de la enfermedad, especialmente en pacientes con ventilación mecánica asistida con un alto índice de mortalidad.
Artificial Intelligence in Health Care: The Hope, the Hype, the Promise, the Peril. National Academy of Medicine. Una reseña
Authors: Rojas-Gualdron Diego Fernando
Published: May 2022

Artificial Intelligence in Health Care: The Hope, the Hype, the Promise, the Peril (1) es un libro publicado en 2019 por la Academia Nacional de Medicina (ANM) de los Estados Unidos. Las aplicaciones en inteligencia artificial (IA) y aprendizaje de máquinas han sido de especial interés para la Academia por lo cual estableció la Digital Health Learning Collaborative desde la cual se gestó esta obra escrita en ocho capítulos. En cumplimiento con la política editorial de la Academia este informe fue revisado por un panel de pares en condiciones de diversidad de perspectivas y experticia técnica.
Rapid cultivation of anammox sludge based on Ca-alginate cell beads
Authors: Gao Qi , Li Shan-Wei , Xie Yu-Jie , Zheng Min-Xue , Wei Jing , Luo Zhi-Jun , Zhou Xiang-Tong , Liu Zhi-Gang , Li Yan , Wu Zhi-Ren
Published: May 2022

Current gel entrapment technology has certain advantages for the enrichment of anammox sludge. In this study, the optimal preparation conditions and cultivation equipment of Ca-alginate cell beads for the culturing anammox sludge were proposed. The preparation parameters of the Ca-alginate cell beads were as follows: 3% sodium alginate, 4% CaCl2, VSA:Vcell = 1:1, a drop height of 9 cm, stirring speed of 300 rpm, and cross-linking time of 24 h. The prepared cell beads were regular spheres with a uniform size and hard texture. Throughout the 9 days of cultivation, the number of anammox bacteria in the Ca-alginate cell beads was 4.3 times that of the initial sludge, and the color of the cell beads changed from yellowish-brown to reddish-brown. Scanning electron microscopy (SEM) analysis showed that the SA gel beads had a good microporous structure. The fluorescence in situ hybridization (FISH) results illustrated that the bacteria were mostly dispersed inside the Ca-alginate cell beads. Additionally, the qPCR results implied that only a relatively small amount of anammox biomass (2.74×106 copies/gel-bead) was required to quickly start the anammox process. The anammox bacteria in the Ca-alginate cell beads grew with a fast growth rate in a short period and exhibited high activity due to diffusion limitations. In addition, the anammox bacteria cultivated in the Ca-alginate cell beads could adapt to the increase in substrate concentration in a short period. The optimal incubation time of this gel entrapment method for anammox sludge was no more than 17 days under the experimental conditions of this work. Therefore, this simple and practicable gel entrapment method may serve as a suitable pre-culture means for the rapid enrichment of anammox bacteria.
Evaluating surfaces of titanium dental implants after contact with surgical gloves, steel rongeur, and titanium tweezers using scanning electron microscopy
Authors: Tatiana Miranda Deliberador  , Caroline Moreira Auersvald  , Maurício Santos de Araújo  , Luís Henrique Chaves  , Allan Fernando Giovanini  , João César Zielak
Published: May 2022

To use scanning electron microscopy (SEM) and determine whether the surfaces of titanium implants are damaged when touched with a steel rongeur, titanium tweezers, or surgical gloves. Material and methods: Ten dental implants were divided into five groups: Control (C), Titanium Tweezers (T-T), Steel Rongeurs (S-R), Surgical Gloves (S-G), and Steel Support (S-S). The implants were assembled in a metallic base (stub) with the aid of copper strips. They were then imaged and their microstructures were characterized using SEM. Results: An analysis of the obtained images showed that the implants that had been handled with titanium tweezers or a steel rongeur suffered some damage to their physical structure; "scratches" and other small signs of damage were visible on their surfaces. The affected areas were very small compared to the total surface area of the implants. Small dark local stains were observed at the spots where some of the implants had rubbed against a steel support. The rubbing of the implants against the support did not cause any structural damage. The implants handled with surgical gloves exhibited many dark stains their surfaces. This suggested that the powder from the surgical gloves had contaminated the surfaces of the implants. Conclusion: Using SEM imaging, it was determined that the surfaces of dental implants suffer minor physical damage when handled with various pieces of dental equipment. However, the damage should not result in failure of the osseointegration process. In vivo studies are needed to confirm this hypothesis.
Epidemiological profile of ameloblastoma at Erasto Gaertner Hospital
Authors: Daniela Cristina Lunelli  , Fernando Luiz Zanferrari  , Juliana Lucena Schussel  , Laurindo Moacir Sassi  , Sérgio Ossamu Ioshii
Published: May 2022

Ameloblastoma is the most common benign tumor of odontogenic origin, and represents about 11% of all odontogenic tumors. It is characterized by being locally aggressive and having high recurrence rates. Objective: To evaluate the occurrence of ameloblastoma in the Erasto Gaertner Hospital in patients from 1972 to 2012. In addition, to assess the main treatments, the most prevalent histological variants, the recurrence rate, the anatomical location of the lesion and patient profile. Material and methods: A retrospective study of patients diagnosed with ameloblastoma at the Erasto Gaertner Hospital between the years 1972-2012 was performed. Epidemiological data were collected such as gender, age, race, lesion location, type of surgical procedure, follow-up and recurrence rate; and analyzed using descriptive statistics. Results:A total of 40 patients were selected for the study. The most affected age group was between the third and fifth decade of life, with 19 cases (47.5%), followed by the second and fourth decade, with 14 cases (35%); the sixth decade, with 5 cases (12.5%) and seventh decade with 1 case (2.5%). The patients’ ages ranged from 13 to 66 years, with an average age 34.9 years. The mandible was the most affected site, with 38 cases (95%) of cases, and maxilla had only 2 cases (5%). Thirty-eight patients were treated with radical surgery and 5 patients presented recurrence after 1 year of follow-up. Both cases that occurred in maxilla presented recurrence. Conclusion: Recurrence of ameloblastoma decreases significantly when surgery is performed properly, with wide excision and margin. Combination of full tumor resection and reconstruction was the best approach observed in this study. In addition, we recommend a long period of clinical and radiographic follow-up.
AH Plus extrusion into periapical tissue: literature review of main related properties and report of clinical cases
Authors: Karen Lys Hubbe  , Kauhanna Vianna de Oliveira  , Beatriz Serrato Coelho  , Flares Baratto-Filho
Published: May 2022

The sealers were developed for filling of root canals. Due to their physicochemical and technical properties used for obturation, often, extrusion is observed through apical constriction and occasionally by lateral and secondary canals. Objective: To review the literature on important properties to be considered in AH Plus sealer extrusion and report a case series of this sealer extrusion. Literature review: Articles evaluating the cytotoxicity and biocompatibility properties, besides flow and solubility were selected. Case report: In the presented cases, endodontic treatment was performed with rotary instrumentation and irrigation with 2.5% NaOCl. Obturation employed visual, tactile, and radiographic proof of gutta-percha main cone, and different obturation techniques. There were no reports of pain during and after endodontic treatment. Conclusion: AH Plus has adequate properties for a filling material and causes no major damage to the periapical tissues due to its little cytotoxic.
Association of Nutrients, Specific Dietary Patterns, and Probiotics
with Age-related Macular Degeneration
Authors: Cao Yanqun , Li Yuli , Gkerdi Antonia , Reilly James , Tan Zhoujin , Shu Xinhua
Published: May 2022

Age-related macular degeneration (AMD) is a complex disease that mainly affects those over 50 years old. Even though management of the vascularisation associated with the ‘’wet’’ form of AMD is effective using anti-VEGF drugs, there is currently no treatment for the ‘’dry’’ form of AMD. Given this, it is imperative to develop methods for disease prevention and treatment. For this review, we searched scientific articles via PubMed and Google Scholar, and considered the impact of nutrients, specific dietary patterns, and probiotics on the incidence and progression of AMD. Many studies revealed that regular consumption of foods that contain ω-3 fatty acids is associated with a lower risk for late AMD. Particular dietary patterns – such as the Mediterranean diet that contains ω-3 FAs-rich foods (nuts, olive oil and fish) – seem to be protective against AMD progression compared to Western diets that are rich in fats and carbohydrates. Furthermore, randomized controlled trials that investigated the role of nutrient supplementation in AMD have showed that treatment with antioxidants such as lutein/zeaxanthin, zinc, and carotenoids may be effective against AMD progression. More recent studies have investigated the association of the antioxidant properties of gut bacteria such as Bacteroides and Eysipelotrichi, with lower AMD risk in individuals whose microbiota is enriched with them. These are promising fields of research that may yield the capacity to improve quality of life for millions of people, allowing them to live with clear vision for longer and avoiding the high cost of vision-saving surgery.
Probiotics as an Adjuvant for Management of Gastrointestinal Cancers
through their Anti-inflammatory Effects: A Mechanistic Review
Authors: Javid Hossein , Karimi-Shahri Mehdi , Khorramdel Malihe , Mashhad Alireza S. , Tabrizi Ayda T. , Sathyapalan Thozhukat , Afshari Amir R. , Sahebkar Amirhossein
Published: May 2022

The immune system's role in maintaining the health of the gastrointestinal
(GI) system is like a double-edged sword. Simultaneously, it could reduce the risk of
pathogen invasion by the inflammatory response. However, if regulated improperly, it
could also propagate oncogenic signaling that transfers a normal cell into the malignant
counterpart. Thus, several mechanisms have been proposed, such as the immune system
could disturb the GI homeostasis and increase the survival and proliferative capacity of
cells, leading to the formation of a wide range of malignancies. Among the endless list of
these mechanisms, inflammatory responses are currently fascinating research areas, as
this response regulation is by the gut microbiota. Given this, microbiota manipulation
might be a convenient and efficient way to prevent GI cancer. Probiotics could potentially
achieve this by overturning the milieu in favor of normal gut homeostasis. In addition
to the safety of the use of probiotics, along with their potential ability to interact with immune
system responses, these bacteria are also being analyzed from the perspective of dietary
supplements. In the present review, we aimed to look into the mechanisms through
which probiotics modulate immune response to stimulate anti-inflammatory responses
and promote immune surveillance against neoplastic cells.
Paravalvular Leak: A Systemic Review
Authors: Randall Morgan , Betageri Omkar , Hanayneh Seri , Anderson R. David
Published: May 2022

Background:

Paravalvular Leak (PVL) refers to the retrograde flow of blood in the
space between an implanted cardiac valve and native tissue. These are unfortunately but luckily
relatively uncommon complications of prosthetic valve replacement that, especially when moderate
or severe, have important clinical consequences.

Objective:

Addressing PVL requires a multidisciplinary team to properly diagnose this process and
choose the corrective option most likely to result in success.

Methods:

A comprehensive literature search was undertaken to formulate this narrative review.

Results:

This review highlights the complex nature of PVL and the promising contemporary treatments
available.

Conclusion:

Clinicians should be adept at recognizing PVL and characterizing it using multimodality
imaging. Using the many available tools and a multidisciplinary approach should lead to favorable
outcomes in patients with PVL.
An Overview of Clinically Imperative and Pharmacodynamically Significant
Drug Interactions of Renin-Angiotensin-Aldosterone System (RAAS)
Blockers
Authors: Balasubramanian Rajkapoor , Mohamed Pakkir Maideen Naina , Muthusamy Sudha , Nallasamy Venkateswaramurthy
Published: May 2022

Introduction:

Hypertension is a leading cause of cardiovascular disease and chronic
kidney disease, resulting in premature death and disability. The Renin-Angiotensin-Aldosterone
System (RAAS) blockers, including Angiotensin-Converting Enzyme (ACE) inhibitors or Angiotensin
Receptor Blockers (ARBs), are used as first-line antihypertensive therapy to treat hypertensive
patients with comorbidities, including diabetes, ischemic heart disease, heart failure, and
chronic kidney disease. The use of RAS blockers is associated with the risks, such as hyperkalemia,
angioedema, etc. The drugs potentiating them interact pharmacodynamically, resulting in adverse
consequences. This review article focuses on the clinically important drug interactions of
RAAS blockers.

Materials and Methods:

The electronic databases, such as Medline/PubMed Central/PubMed,
Google Scholar, ScienceDirect, Cochrane Library, Directory of Open Access Journals (DOAJ),
Embase, and reference lists were searched to identify relevant articles.

Results:

The risk of hyperkalemia may be enhanced potentially in patients receiving a RAS blocker
and potassium-sparing diuretics, potassium supplements, trimethoprim, adrenergic betablockers,
antifungal agents, calcineurin inhibitors, pentamidine, heparins or an NSAID, concomitantly.
The patients taking ACE inhibitors and mTOR inhibitors, DPP4 inhibitors, alteplase, or
sacubitril/valsartan concurrently may be at increased risk of developing angioedema.

Conclusion:

Clinicians, pharmacists, and other healthcare practitioners should be accountable for
medication safety. To avoid adverse implications, prescribers and pharmacists must be aware of
the drugs that interact with RAAS blockers.
Mesenchymal Stem Cell-based Therapy and Female Infertility: Limitations
and Advances
Authors: Ghajari Ghazal , Heydari Arefe , Ghorbani Masoud
Published: May 2022

:

Infertility in women can be caused by various female reproductive diseases such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis and Asherman syndrome that affect couples' quality of life and lead to mental, emotional, and physical problems. In recent years, clinical researchers have sought infertility treatments using new methods that are more effective and non-invasive than the old methods.
Today, stem cell-based therapy has been introduced as a promising method and an alternative to the old strategy of infertility treatment. Understanding the main features and functional perspective of mesenchymal stem cells (MSCs) in the future of infertility by physicians is crucial.
Mesenchymal stem cells (MSCs) are multipotent stem cells with a high proliferation range, abundant source and multidirectional differentiation potential. They have high potential for the treatment of injured tissues in regenerative medicine through cell homing, secretion of active factors, and participation in immune regulation. At present, due to fewer ethical restrictions on the use of mesenchymal stem cells compared to embryonic stem cells, more attention has been paid to these cells as a new treatment for gynecological disorders. In this paper, we first review the various type of female reproductive disorders along with their common treatment methods, then we evaluate the recent advances in the application of MSCs in the diseases related to infertility and improve the reproductive health of women worldwide.
Mesenchymal Stem Cells Attenuate Sepsis-associated Acute Kidney Injury
by Changing the Balance of Th17 cells/Tregs via Gal-9/Tim-3
Authors: Luo Congjuan , Luo Feng , Man Xiaofei , liu Xuemei , Zhao Long , Che Lin , Zhang Wei , Guo Junjie , Cai Shixia , Wang Dawei , Xu Yan
Published: May 2022

Objective:

The aim of the present study was to investigate the protective effect of MSCs on
CLP-induced SA-AKI and determine the mechanisms of this effect.

Methods:

The expression of Gal-9 and Tim-3 was assayed by qPCR and western blot. IL-10, IL-17,
RORγt, and FOXP3 were assayed by qPCR and TNFα, INFγ, IL-4, and IL-6 were assayed by ELISA in
renal samples after CLP with or without MSCs treatment. The expression of Gal-9 in MSCs was knocked
down in vivo using RNA interference, and si-Gal-9-MSCs were injected in SA-AKI mice. The effect of
MSCs on the differentiation of lymphocytes into Th17 cells and Tregs was evaluated in vitro by FAC in
coculture of MSCs and CD4+ T cells and after blockade of the Gal-9/Tim-3 pathway.

Results:

MSCs decreased serum creatinine and urea nitrogen levels and relieved tubular injury. Additionally,
MSCs significantly improved the survival rate and markedly attenuated the infiltration of neutrophils
and the levels of TNF-α, IFN-γ, IL-4, and IL-6 in the kidneys of septic mice (P < 0.05). Treatment with
MSCs also reduced the proportion of Th17 cells and the levels of IL-17 and RORγt (P < 0.05). In contrast,
MSCs increased the proportion of Tregs and the levels of IL-10 and FOXP3 related to these cells (P
< 0.05). Furthermore, we determined whether Gal-9/Tim-3 and Th17 cells/Tregs are involved in the protective
effects of MSCs in an SA-AKI model. The results of Western blot and real-time PCR indicated
that MSCs inhibited the expression of Tim-3 and increased the expression of gal-9 (P < 0.05). Knockdown
of gal-9 in MSCs using small interfering RNA blunted the therapeutic effect of MSCs, and blockade
of the Gal-9/Tim-3 pathway using α-lactose or anti-Tim-3 inhibited the induction of Tregs and suppressed
the inhibition of the differentiation to Th17 cells by MSCs after coculture of MSCs with CD4+ T
cells (P > 0.05).

Conclusion:

Treatment with MSCs can protect against SA-AKI. The results suggested that the relieving
effect of MSCs against SA-AKI may be partially mediated by the induction of Tregs and inhibition of
Th17 cells via the Gal-9/Tim-3 pathway.
Examining the Mechanisms of Huachansu Injection on Liver Cancer
through Integrated Bioinformatics Analysis
Authors: Huang Chao-yuan , Cheng Yi-min , Li Wei , Huang Yuan-cheng , Luo Hu , Zhong Chong , Liu Feng-bin
Published: May 2022

Objective:

The objective of this study is to explore the potential anti-liver cancer mechanism
of Huachansu injection through integrated bioinformatics analysis.

Methods:

Active ingredients of Huachansu injection (extraction of toad skin) were obtained, and
their potential drug targets were predicted via SwissTargetPrediction database. Liver cancer disease
targets were identified from the GEO (Gene Expression Omnibus) dataset and four public databases.
Then Protein-Protein Interaction (PPI) network of toad skin was constructed. GO (Gene Ontology)
enrichment analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis
were performed subsequently. Finally, molecular docking was performed using Auto Dock Vina.

Results:

In the search for therapeutic targets, twenty active components of toad skin were screened
for further study, five hundred and sixty-eight targets of components were identified. In the search for
disease targets, three thousand two hundred and twenty-seven genes were identified after removal of
duplicated genes, one hundred and fifty-nine genes were up-regulated in liver cancer samples while
two hundred and seventy-eight were down-regulated in liver cancer patients. After predicting the
therapeutic targets of the components, the results were cross-checked with the disease targets, thirteen
up-regulated targets and ten down-regulated targets were obtained. Finally, in the results of molecular
docking, seven targets (CDK1, AKR1B1, MMP12, AURKB, CHEK1, AURKA, TTK) were
potential up-regulated targets, three targets (SHBG, SRD5A2, NR1I2) were potential down-regulated
targets, all of which have the best binding energy and molecular interactions.

Conclusion:

CDK1, AKR1B1, MMP12, AURKB, CHEK1, AURKA, and TTK could be potential upregulated
target proteins of Huachansu injection for treating liver cancer. The mechanism of Huachansu
injection in the treatment of liver cancer through these up-regulated targets is related to cell cycle, cellular
senescence, viral carcinogenesis, p53 signaling pathway. SHBG, SRD5A2, and NR1I2 could be potential
down-regulated target proteins of Huachansu injection in treating liver cancer.
Recent Advances and Therapeutic Journey of Schiff Base Complexes with Selected
Metals (Pt, Pd, Ag, Au) as Potent Anticancer Agents: A Review
Authors: Khan Sikandar , Alhumaydhi Fahad A. , Ibrahim Munjed M. , Alqahtani Ali , Alshamrani Meshal , Alruwaili Abdullah S. , Hassanian Athar A. , Khan Sajad
Published: May 2022

Schiff bases and their transition metal complexes play an important role in the field of medicine, in particular
in the treatment of cancer. Since the discovery of the cisplatin anticancer activity, great efforts have focused on the
rational design of metal-based anticancer drugs that can be potentially used for the treatment of cancer. However, drug
resistance and significant side effects greatly limit its clinical application. This has inspired medicinal chemists to
employ various strategies in the development of novel and effective anticancer drugs. Recently, a greater number of
transition metal complexes have been designed and evaluated for their anticancer activities, and some of them were at
different stages of clinical studies. Amongst these, platinum, palladium, gold and silver complexes have an important
place within medicinal and inorganic chemistry. This review article discusses Schiff bases and their complexes with
selected transition metals (Pd, Pt, Ag, Au) for anticancer activity against different cancer cell lines.
The Emerging Role of Marine Natural Products for the Treatment of
Parkinson’s Disease
Authors: Deepika N.P. , Rahman Md. H. , Chipurupalli S. , Shilpa T.N. , Duraiswamy B.
Published: May 2022

Parkinson's Disease (PD), known as Parkinsonism, is a neurodegenerative disease that mainly affects the elderly and is characterized by an extensive and progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). Owing to genetic, environmental, and lifestyle changes, the incidence of PD has recently risen among adults. The most widely used PD treatment strategies include the use of dopamine agonists, anticholinergics, and enzyme inhibitors. The aquatic flora and fauna have become the emerging source of novel, structurally diverse bioactive compounds and, at present, the researchers concentrate their efforts on isolating, characterizing, and identifying many secondary metabolites of different nature to treat various disorders, including, neuroprotective marine natural products (MNPs). The bioactive peptides, tannins, carotenoids, alkaloids, polyunsaturated fatty acids (PUFA), and sulfated polysaccharides from the MNP’s and their synthetic derivatives have demonstrated important neuroprotective activity in preclinical studies through multiple mechanisms. An extensive literature survey was carried out, and published articles from PubMed, Scifinder, Google Scholar, Web of Science, and Scopus were carefully reviewed to compile information on the MNPs to treat PD. This current review focus on neuroprotective MNPs and their probable biological pathways to treat PD based on their structure and bioactivities reported from 1990 to 2020
Wavelet DE-noising and Kalman Filtering of MEMS Sensors for Autonomous
Latitude Determination
Authors: Avrutov Vadym , Bouraou Nadiia , Davydenko Sergii , Hehelskyi Oleksii , Lakoza Sergii , Matvienko Olena , Pazdrii Olha
Published: May 2022

Background:

There is a task of autonomous determination of the position latitude of unmoved
vehicles. Also, there is another task of the initial value latitude determination as a prepared operation
of gimbaled and strap-down inertial navigation systems. For both cases, it is necessary to have
an inertial measurement unit (IMU) with triad gyroscopes and triad accelerometers. The output signals
of micromechanical gyroscopes and accelerometers have large noise components when using the IMU
in the micromachined electromechanical systems (MEMS) technology.

Objective:

Normally to filter output signals of MEMS sensors, averaging and filtering are used. However,
for Kalman filtering, it is necessary to find the exact mathematical model of the sensors and a lot
of their initial random characteristics. The study of the possibility of the wavelet transform usage to
filter the output signals MEMS accelerometers and gyroscopes for the latitude autonomous determination
was conducted in the paper.

Method:

The wavelet transform approach was used to filter the output signals of MEMS accelerometers
and gyroscopes in order to improve the accuracy of the autonomous position latitude determination.
The autonomous latitude determination efficiency of IMU based on MEMS gyroscopes and accelerometers
has been experimentally confirmed. The projections of the Earth’s angular rate and gravitational
acceleration were obtained from the MEMS IMU. After that, the signals of the IMU gyroscopes
and accelerometers were filtered, using the wavelet ‘Daubechies’ in decomposition, and averaged.
These signals were used in a computational algorithm to determine the latitude.

Results:

The results showed that Unlike the well-known Kalman filter wavelet de-noising reduced
calculation error by almost twice.

Conclusion:

Wavelet de-noising could be used for output signals filtering of micromechanical gyroscopes
and accelerometers for the autonomous determination of position latitude.
Rendimiento y variables poscosecha de cultivares de papa del grupo Phureja en ambientes contrastantes por altitud de la región Andina central de Colombia
Authors: Lizarazo Peña Pedro Alfonso , Moreno Fonseca Liz Patricia , Ñústez López Carlos Eduardo
Published: May 2022

Colombia presenta alta diversidad de genotipos de papa diploide (Solanum tuberosum, grupo Phureja), cultivados en un amplio rango altitudinal. El objetivo de esta investigación fue evaluar el efecto de la altitud en el rendimiento y la calidad poscosecha de cultivares mejorados de papa del grupo Phureja. Para ello, se empleó un arreglo factorial completo en bloques generalizados, cuyo primer factor fue el cultivar (Criolla Colombia, Criolla Dorada, Criolla Ocarina, Paola y Violeta) y el segundo, la localidad con altitudes contrastantes (3.200, 2.700 y 2.300 m s.n.m.). Las variables de productividad evaluadas fueron rendimiento, porcentaje por categoría comercial y número de tubérculos, mientras que las de calidad fueron gravedad específica, respuesta a fritura y, para el cultivar violeta, pigmentación en tubérculo. Se presentaron diferencias significativas en todas las variables evaluadas, por la interacción de la localidad por cultivar. Criolla Dorada fue el cultivar más estable en rendimiento entre localidades. En la localidad baja, se afectó la productividad de los cultivares Criolla Ocarina, Paola y Violeta, a diferencia de localidades con mayor altitud, donde se favoreció el rendimiento y porcentaje de papa “categoría primera” en todos los cultivares. Una mayor altitud de la localidad favoreció el número de tubérculos por sitio en Criolla Ocarina, la gravedad específica en Criolla Dorada y la pigmentación en tubérculo de Violeta, pero afectó negativamente la fritura en todos los cultivares. Teniendo en cuenta que la altitud de siembra afectó todas las variables evaluadas con diferencias por cultivar, se debe considerar esta interacción al momento de establecer cultivos de papa del grupo Phureja.
The Value of Extracting Clinician-Recorded Affect for Advancing Clinical Research on Depression: Proof-of-Concept Study Applying Natural Language Processing to Electronic Health Records
Authors: Panaite Vanessa , Devendorf Andrew R , Finch Dezon , Bouayad Lina , Luther Stephen L , Schultz Susan K
Published: May 2022

Background

Affective characteristics are associated with depression severity, course, and prognosis. Patients’ affect captured by clinicians during sessions may provide a rich source of information that more naturally aligns with the depression course and patient-desired depression outcomes.

Objective

In this paper, we propose an information extraction vocabulary used to pilot the feasibility and reliability of identifying clinician-recorded patient affective states in clinical notes from electronic health records.

Methods

Affect and mood were annotated in 147 clinical notes of 109 patients by 2 independent coders across 3 pilots. Intercoder discrepancies were settled by a third coder. This reference annotation set was used to test a proof-of-concept natural language processing (NLP) system using a named entity recognition approach.

Results

Concepts were frequently addressed in templated format and free text in clinical notes. Annotated data demonstrated that affective characteristics were identified in 87.8% (129/147) of the notes, while mood was identified in 97.3% (143/147) of the notes. The intercoder reliability was consistently good across the pilots (interannotator agreement [IAA] >70%). The final NLP system showed good reliability with the final reference annotation set (mood IAA=85.8%; affect IAA=80.9%).

Conclusions

Affect and mood can be reliably identified in clinician reports and are good targets for NLP. We discuss several next steps to expand on this proof of concept and the value of this research for depression clinical research.
Internet-Delivered Interventions for Depression and Anxiety Symptoms in Children and Young People: Systematic Review and Meta-analysis (Preprint)
Authors: Eilert Nora , Wogan Rebecca , Leen Aisling , Richards Derek
Published: May 2022

BACKGROUND

Mental health difficulties in children and adolescents are highly prevalent; however, only a minority receive adequate mental health care. Internet-delivered interventions offer a promising opportunity to increase access to mental health treatment. Research has demonstrated their effectiveness as a treatment for depression and anxiety in adults. This work provides an up-to-date examination of the available intervention options and their effectiveness for children and young people (CYP).

OBJECTIVE

In this systematic review and meta-analysis, we aimed to determine the evidence available for the effectiveness of internet-delivered interventions for treating anxiety and depression in CYP.

METHODS

Systematic literature searches were conducted throughout November 2020 using PubMed, PsycINFO, and EBSCO academic search complete electronic databases to find outcome trials of internet-delivered interventions treating symptoms of anxiety and/or depression in CYP by being either directly delivered to the CYP or delivered via their parents. Studies were eligible for meta-analysis if they were randomized controlled trials. Risk of bias and publication biases were evaluated, and Hedges g between group effect sizes evaluating intervention effects after treatment were calculated. Meta-analyses used random-effects models as per protocol.

RESULTS

A total of 23 studies met the eligibility criteria for the systematic review, of which 16 were included in the meta-analyses, including 977 participants in internet-delivered treatment conditions and 1008 participants in control conditions across 21 comparisons. Random-effects models detected a significant small effect for anxiety symptoms (across 20 comparisons; Hedges g=−0.25, 95% CI −0.38 to −0.12; P<.001) and a small but not significant effect for depression (across 13 comparisons; Hedges g=−0.27, 95% CI −0.55 to 0.01; P=.06) in favor of internet-delivered interventions compared with control groups. Regarding secondary outcomes, there was a small effect of treatment across 9 comparisons for impaired functioning (Hedges g=0.52, 95% CI 0.24-0.80; P<.001), and 5 comparisons of quality of life showed no effect (Hedges g=−0.01, 95% CI −0.23 to 0.21; P=.94).

CONCLUSIONS

The results show that the potential of internet-delivered interventions for young people with symptoms of anxiety or depression has not been tapped into to date. This review highlights an opportunity for the development of population-specific interventions and their research to expand our current knowledge and build an empirical base for digital interventions for CYP.

CLINICALTRIAL

PROSPERO CRD42020220171; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=220171
Indoor Temperatures in the 2018 Heat Wave in Quebec, Canada: Exploratory Study Using Ecobee Smart Thermostats (Preprint)
Authors: Oetomo Arlene , Jalali Niloofar , Costa Paula Dornhofer Paro , Morita Plinio Pelegrini
Published: May 2022

BACKGROUND

Climate change, driven by human activity, is rapidly changing our environment and posing an increased risk to human health. Local governments must adapt their cities and prepare for increased periods of extreme heat and ensure that marginalized populations do not suffer detrimental health outcomes. Heat warnings traditionally rely on outdoor temperature data which may not reflect indoor temperatures experienced by individuals. Smart thermostats could be a novel and highly scalable data source for heat wave monitoring.

OBJECTIVE

The objective of this study was to explore whether smart thermostats can be used to measure indoor temperature during a heat wave and identify houses experiencing indoor temperatures above 26°C.

METHODS

We used secondary data—indoor temperature data recorded by ecobee smart thermostats during the Quebec heat waves of 2018 that claimed 66 lives, outdoor temperature data from Environment Canada weather stations, and indoor temperature data from 768 Quebec households. We performed descriptive statistical analyses to compare indoor temperatures differences between air conditioned and non–air conditioned houses in Montreal, Gatineau, and surrounding areas from June 1 to August 31, 2018.

RESULTS

There were significant differences in indoor temperature between houses with and without air conditioning on both heat wave and non–heat wave days (P<.001). Households without air conditioning consistently recorded daily temperatures above common indoor temperature standards. High indoor temperatures persisted for an average of 4 hours per day in non–air conditioned houses.

CONCLUSIONS

Our findings were consistent with current literature on building warming and heat retention during heat waves, which contribute to increased risk of heat-related illnesses. Indoor temperatures can be captured continuously using smart thermostats across a large population. When integrated with local heat health action plans, these data could be used to strengthen existing heat alert response systems and enhance emergency medical service responses.
The Value of Extracting Clinician-Recorded Affect for Advancing Clinical Research on Depression: Proof-of-Concept Study Applying Natural Language Processing to Electronic Health Records (Preprint)
Authors: Panaite Vanessa , Devendorf Andrew R , Finch Dezon , Bouayad Lina , Luther Stephen L , Schultz Susan K
Published: May 2022

BACKGROUND

Affective characteristics are associated with depression severity, course, and prognosis. Patients’ affect captured by clinicians during sessions may provide a rich source of information that more naturally aligns with the depression course and patient-desired depression outcomes.

OBJECTIVE

In this paper, we propose an information extraction vocabulary used to pilot the feasibility and reliability of identifying clinician-recorded patient affective states in clinical notes from electronic health records.

METHODS

Affect and mood were annotated in 147 clinical notes of 109 patients by 2 independent coders across 3 pilots. Intercoder discrepancies were settled by a third coder. This reference annotation set was used to test a proof-of-concept natural language processing (NLP) system using a named entity recognition approach.

RESULTS

Concepts were frequently addressed in templated format and free text in clinical notes. Annotated data demonstrated that affective characteristics were identified in 87.8% (129/147) of the notes, while mood was identified in 97.3% (143/147) of the notes. The intercoder reliability was consistently good across the pilots (interannotator agreement [IAA] >70%). The final NLP system showed good reliability with the final reference annotation set (mood IAA=85.8%; affect IAA=80.9%).

CONCLUSIONS

Affect and mood can be reliably identified in clinician reports and are good targets for NLP. We discuss several next steps to expand on this proof of concept and the value of this research for depression clinical research.
Implementation planning to promote research best practice in non-government organisations in the Torres Strait. (Preprint)
Authors: Shibasaki Sanchia , Watkin Lui Felecia , Ah Mat Lynda
Published: May 2022

BACKGROUND

Aboriginal and Torres Strait Islander people have been involved in research for many years (2-4). However, for research involving Aboriginal and Torres Strait Islander people it appears the primary benefactors continues to be researchers, with limited or no research knowledge being mobilised to end users, such as individuals and communities who stand to benefit from the outputs and outcomes (7-9).

OBJECTIVE

We examined how implementation planning informed our approach to develop a multi-faceted approach to promote a set of guidelines to Torres Strait Islander people on research best practice.

METHODS

The methods included a literature review, participant observations and interviews.

RESULTS

The literature review identified 3 research guidelines on Aboriginal and Torres Strait Islander health research and one evaluation of a set of guidelines. Interview findings suggested there was ongoing frustration with researcher and the research process. Barriers included engagement with research included: limited awareness of the guidelines, lack of interest, distrust, limited time, limited backfill to support staff to attend training, and resistance to change current practice.

CONCLUSIONS

Publishing paper-based and online copies of guidelines and evaluating their effectiveness does not guarantee research in practice will be considered meaningful, ethical, and beneficial to participants and end users. Increasing awareness and use of the guidelines requires a team to draw on KT and/or implementation planning evidence. This requires equal investment in resources to ensuring research products and practices are implemented and achieve positive impact for the end-user.
Authors’ Reply to: Clarity on the Type of Review. Comment on “Value Cocreation in Health Care: Systematic Review” (Preprint)
Authors: Peng Yuxin , Wu Tailai , Chen Zhuo , Deng Zhaohua
Published: May 2022

UNSTRUCTURED

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