bluuebunny/crossref_metadata_2025 huggingface dataset:
Fine-Crush Straw Returning Enhances Dry Matter Accumulation Rate of Maize Seedlings in Northeast China
Authors: Zhao Jiale , Wang Xiaogeng , Zhuang Jian , Cong Yongjian , Lu Yun , Guo Mingzhuo
Published: June 2021

In the conventional straw returning operation, the maize straw is broken into pieces of about 10 cm and degraded naturally in the farmland. Under the conventional straw returning mode, maize straw does not easily decompose quickly in cold climate conditions, which can cause a significant decrease in the dry matter accumulation rate of next maize seedlings. Therefore, it is difficult to popularize conventional straw returning in the maize-growing regions of Northeast China. In order to solve the above-mentioned problems, a new agronomic technology of straw returning is proposed in this study, and a corresponding Bionic Straw Fine Crusher is developed to match the agronomic requirements. The key function of fine-crush straw returning is to significantly increase the contact area between the straw pith and the external environment by significantly shortening the crushing length, thus accelerating the rate of straw decomposition. In this study, the differences in operational effects between fine-crush straw returning, conventional straw returning, and no returning are clarified through 6 consecutive years of field experiments. At the same time, statistical analysis of the experimental data reveals the influence of fine-crush straw returning on the dry matter accumulation of maize at the seedling stage under the conditions of different returning modes, and determines the optimal agronomic parameter combination. The results of this study show that fine-crush straw returning significantly increased the decomposition rate, soil organic matter content, and soil accumulated temperature, thus creating a seedbed more favorable for maize seedling development. The experimental results showed that the optimal crushing length values of fine-crush straw returning were 1.5 cm, 3 cm, and 1.5 cm under mulching returning, shallow burial returning, and deep tillage returning conditions, respectively. Compared with conventional straw returning and no returning operations, the fine-crush straw returning operation can increase the maximum seedling dry matter accumulation of the maize crop by 5.1 g/plant and 2.8 g/plant (shallow burial), 4.2 g/plant and 1.8 g/plant (deep tillage), and 4.3 g/plant and 1.9 g/plant (mulching returning). The findings of this study may provide a viable new agronomic technology to accelerate the spread of straw returning in maize-growing areas of Northeast China.
Agronomic and In Vitro Quality Evaluation of Dual-Purpose Cereals Clipped at Variable Ages and Their Utilization in Rabbit Feeding
Authors: Salama Heba S. A. , Safwat Assem M. , Elghalid Osama H. , Abd El-Hady Ahmed M.
Published: June 2021

The present study included two experiments; the first one investigated the forage productivity and in vitro quality of a single cut taken at different plant ages (45, 60, and 75 days after sowing—DAS) from four prominent cereal crops, namely, barley, oat, triticale, and ryegrass, grown during two successive winter seasons in Northern Egypt. In addition, the effect of plant age at forage removal on the crop’s regrowth ability and final grain yield was quantified. The second experiment studied the biological in vivo effects of the four crops’ hay cut at the optimum plant age on growth performance, feed utilization, and apparent nutrients’ digestibility of growing rabbits. Despite the progressive increase in the fresh and dry matter yields produced from the four crops with later forage removal and the relatively high quality of the forage removed at 45 DAS, 1st experiment concluded that forage removal at 60 DAS produced a reasonable amount of fresh and dry matter yields with appropriate in vitro quality. Meanwhile, the gain in forage yield, when forage was removed at 60 DAS, was enough to compensate for the consequent reduction in grain yield of the four evaluated crops. The inclusion of variable percentages (0, 10, and 20%) of the four tested crops’ hay, when cut at 60 DAS, in the rabbit’s diet (2nd experiment), resulted in non-significant variations in the rabbit’s final body weight. Meanwhile, regardless of the percentage, the rabbits that were fed on diets including ryegrass hay and barley hay had the highest significant daily weight gain. The best feed conversion ratios were obtained by the rabbits that were fed on diets containing 10 and 20% ryegrass hay as well as 20% triticale hay. The highest dry matter, organic matter, and crude protein digestibility coefficients were obtained by both groups of rabbits that were fed on diets containing 20% ryegrass hay and barley hay. The inclusion of any of the four crops’ hay in the rabbits’ diet resulted in significantly higher digestibility coefficients for all nutrients compared to the control rabbits except for ether extract digestibility. Among the four evaluated crops’ hay, ryegrass hay was found to have an outstanding impact on the productive performance and digestibility of growing rabbits. In growing dual-purpose cereals, it is recommended to cut the crops at 60 DAS to achieve the optimum balance between forage yield and quality on the one hand and final grain yield on the other hand. Moreover, when cut at 60 DAS, the evaluated hay of the four crops was adequate to be included in the rabbits’ diet up to 20% substitution of the commercial fiber sources.
Recent Possibilities for the Diagnosis of Early Pregnancy and Embryonic Mortality in Dairy Cows
Authors: Szenci Ottó
Published: June 2021

One of the most recent techniques for the on-farm diagnosis of early pregnancy (EP) in cattle is B-mode ultrasonography. Under field conditions, acceptable results may be achieved with ultrasonography from Days 25 to 30 post-AI. The reliability of the test greatly depends on the frequency of the transducer used, the skill of the examiner, the criterion used for a positive pregnancy diagnosis (PD), and the position of the uterus in the pelvic inlet. Non-pregnant animals can be selected accurately by evaluating blood flow in the corpus luteum around Day 20 after AI, meaning we can substantially improve the reproductive efficiency of our herd. Pregnancy protein assays (PSPB, PAG-1, and PSP60 RIA, commercial ELISA or rapid visual ELISA tests) may provide an alternative method to ultrasonography for determining early pregnancy or late embryonic/early fetal mortality (LEM/EFM) in dairy cows. Although the early pregnancy factor is the earliest specific indicator of fertilization, at present, its detection is entirely dependent on the use of the rosette inhibition test; therefore, its use in the field needs further developments. Recently found biomarkers like interferon-tau stimulated genes or microRNAs may help us diagnose early pregnancy in dairy cows; however, these tests need further developments before their general use in the farms becomes possible.
Dietary Curcumin Promotes Gilthead Seabream Larvae Digestive Capacity and Modulates Oxidative Status
Authors: Xavier Maria J. , Dardengo Gian Marco , Navarro-Guillén Carmen , Lopes André , Colen Rita , Valente Luisa M. P. , Conceição Luís E. C. , Engrola Sofia
Published: June 2021

The larval stage is highly prone to stress due to the ontogenetic and metabolic alterations occurring in fish. Curcumin inclusion in diets has been shown to improve growth by modulating oxidative status, immune response, and/or feed digestibility in several fish species. The aim of the present work was to assess if dietary curcumin could promote marine fish larvae digestive maturation and improve robustness. Gilthead seabream larvae were fed a diet supplemented with curcumin at dose of 0 (CTRL), 1.5 (LOW), or 3.0 g/Kg feed for 27 days. From 4 to 24 days after hatching (DAH), no differences were observed in growth performance. At the end of the experiment (31 DAH) LOW larvae had a better condition factor than CTRL fish. Moreover, HIGH larvae showed higher trypsin and chymotrypsin activity when compared to CTRL fish. LOW and HIGH larvae were able to maintain the mitochondrial reactive oxygen species production during development, in contrast to CTRL larvae. In conclusion, curcumin supplementation seems to promote larvae digestive capacity and modulate the oxidative status during ontogeny. Furthermore, the present results provide new insights on the impacts of dietary antioxidants on marine larvae development and a possible improvement of robustness in the short and long term.
The Study of Cooling Mechanism Design for High-Power Communication Module with Experimental Verification
Authors: Yu Tsu-Ping , Lee Yung-Lung , Li Ya-We , Mao Shih-Wei
Published: June 2021

With the continued development of 5G mobile communications technology, the implementation of high-power communication systems has become a key indicator of developed nations. Communication modules are also trending toward wide bandwidth and high-capacity Multi-Input and Multi-Output systems. As the signal transmission speed and resolution continue with the increasing trend, the power used to operate these communications systems increase, causing extreme heat generation by transmit/receive modules (T/R module). In conditions where computation load increases in micro design systems, chips must operate in environments that are narrow, sealed, and have no convection, which can drastically increase the thermal load within a system. If no proper cooling system is utilized, the system fails or operates at impacted performance due to excessive temperatures. To solve the aforementioned problem, this study aimed to optimize the design of the cooling system in the T/R modules of communications systems by integrating heat pipes, cooling fans, cooling fins, and cooling chips within a limited space. We also proposed four types of cold plates based on the different directional clamp-in configuration methods of heat pipes within copper panels and utilized the finite element method to simulate and analyze the heat dissipation performance. The simulation results reveal that cold plates of types I and II can achieve a better heat dissipation performance. Finally, types I and II cold plates were selected for production and experimental verification. The results show that heat dissipation performances were similar to simulation results. The results also confirmed that type II cold plate has a better temperature uniformity and heat transfer efficiency. Thus, the cooling mechanism depicted in this study is viable in practical applications. The proposed mechanisms can also provide a reference for heat dissipation design patterns in different electronic module settings.
Analysis of Rip Current Characteristics Using Dye Tracking Method
Authors: Kim Hyun Dong , Kim Kyu-Han
Published: June 2021

Rip currents are strong water channels flowing away from the shoreline. They can occur on any shore with breaking waves. Rip currents play a significant role in changing the topography of shallow water regions by transporting large amounts of bed material offshore. Moreover, they pose a significant danger for people living in nearshore zones and surfers and cause hundreds of deaths annually worldwide. Therefore, rip current generation characteristics have been investigated to prevent casualties. In this study, a GPS drifter survey was chosen as the investigation method; however, a few drawbacks were discovered, such as low accuracy due to the GPS drifter becoming trapped in the surf zone. Therefore, drones and dyes were used to overcome the drawbacks of drifter methods. The results of dye tracking and the 3D wave-induced current numerical simulation were compared; the velocity and formation of the rip current were found to be relatively similar. With the technological advancements and invention of new survey equipment, the survey techniques also evolve, and this paper shows that the disadvantages of the GPS-based Lagrangian method can be overcome using a dye-mounted drone, which observes the rip current easily and accurately.
Repetitive Transcranial Magnetic Stimulation as an Add-On Treatment for Cognitive Impairment in Alzheimer’s Disease and Its Impact on Self-Rated Quality of Life and Caregiver’s Burden
Authors: Teti Mayer Juliana , Masse Caroline , Chopard Gilles , Nicolier Magali , Bereau Matthieu , Magnin Eloi , Monnin Julie , Tio Gregory , Haffen Emmanuel , Vandel Pierre , Bennabi Djamila
Published: June 2021

Alzheimer’s disease (AD) is associated with progressive memory loss and decline in executive functions, as well as neuropsychiatric symptoms. Patients usually consider quality of life (QoL) and mood as more important for their health status than disease-specific physical and mental symptoms. In this open-label uncontrolled trial, 12 subjects diagnosed with AD underwent 10 sessions of repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (10 Hz, 20 min, 2000 pulses/day, 110% MT). Outcomes were measured before and 30 days after treatment. Our primary objective was to test the efficacy of rTMS as an add-on treatment for AD on the global cognitive function, assessed through the Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (MDRS). As secondary objectives, the detailed effect on cognitive functions, depression and anxiety symptoms, QoL, and functionality in daily life activities were evaluated, as well as correlations between QoL and cognition, depression and anxiety scores. The treatment significantly enhanced semantic memory and reduced anxiety. Improvement of these features in AD could become an important target for treatment strategies. Although limited by its design, this trial may contribute with another perspective on the analysis and the impact of rTMS on AD.
Depatuxizumab Mafodotin (Depatux-M) Plus Temozolomide in Recurrent Glioblastoma Patients: Real-World Experience from a Multicenter Study of Italian Association of Neuro-Oncology (AINO)
Authors: Padovan Marta , Eoli Marica , Pellerino Alessia , Rizzato Simona , Caserta Claudia , Simonelli Matteo , Michiara Maria , Caccese Mario , Anghileri Elena , Cerretti Giulia , Rudà Roberta , Zagonel Vittorina , Lombardi Giuseppe
Published: June 2021

Background: Depatuxizumab Mafodotin (Depatux-M; ABT-414) is an antibody-drug conjugate consisting of a specific antibody against activated EGFR and a cytotoxic agent with antimicrotubule activity. The INTELLANCE 2/EORTC 1410 phase 2 trial produced interesting results for the combination regimen of Depatux-M and temozolomide in EGFR-amplified glioblastoma patients at first recurrence. For the first time worldwide, our work investigated the clinical outcome and safety of this combination in a real-life population. Materials and Methods: Patients were enrolled from seven AINO (Italian Association of Neuro-Oncology) Institutions. The major inclusion criteria were: histologically confirmed diagnosis of glioblastoma, EGFR-amplified, one or more prior systemic therapies and ECOG PS ≤ 2. According to the original schedule, patients received Depatux-M 1.25 mg/kg every 2 weeks combined with temozolomide. The primary endpoints of the study were overall survival and safety. Results: A total of 36 patients were enrolled. The median age was 57 years, ECOG PS was 0–1 in 28 patients (88%), MGMT methylated status was found in 22 (64%), 15 patients (42%) received the combined treatment as second-line therapy. The median OS was 8.04 months (95% CI, 5.3–10.7), the 12 month-OS was 37%. On univariate and multivariate analyses, the MGMT methylation status was the only factor resulting significantly associated with survival. Grade 3 ocular toxicity occurred in 11% of patients; no grade 4 ocular toxicity was reported. No death was considered to be drug-related. Conclusions: The study reported the first “real world” experience of Depatux-M plus temozolomide in recurrent glioblastoma patients. Encouraging clinical benefits were demonstrated, even though most patients were treated beyond second-line therapy. Overall, the results are close to those reported in the previous phase 2 trial. Toxicity was moderate and manageable.
3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model
Authors: Mokhtari Reza Bayat , Qorri Bessi , Sambi Manpreet , Baluch Narges , Kumar Sushil , Das Bikul , Szewczuk Myron R. , Yeger Herman , Cheng Hai-Ling Margaret
Published: June 2021

Therapeutic targeting of stem cells needs to be strategically developed to control tumor growth and prevent metastatic burden successfully. Breast cancer presents a unique clinical problem because of the variety of cellular subtypes present, including cancer stem cells (CSCs). The development of 3D stem-like properties of human breast tumor spheroids in stem cell factor conditioned media was investigated in orthotopic xenografts for enhanced tumorgenicity in the athymic nude rat model. MCF-7, ZR-75-1, and MDA-MB-231 breast cancer cell lines were cultured in serum-free, stem cell factor-supplemented medium under non-adherent conditions and passaged to generate 3rd generation spheroids. The spheroids were co-cultured with fetal lung fibroblast (FLF) cells before orthotopic heterotransplantation into the mammary fat pads of athymic nude rats. Excised xenografts were assessed histologically by H&E staining and immunohistochemistry for breast cancer marker (ERB1), proliferation marker (Ki67), mitotic marker (pHH3), hypoxia marker (HIF-2α), CSC markers (CD47, CD44, CD24, and CD133), and vascularization markers (CD31, CD34). Breast cancer cells cultured in stem cell factor supplemented medium generated 3D spheroids exhibited increased stem-like characteristics. The 3D stem-like spheroids co-cultured with FLF as supporting stroma reproducibly and efficiently established orthotopic breast cancer xenografts in the athymic nude rat.
Whole Lung Irradiation after High-Dose Busulfan/Melphalan in Ewing Sarcoma with Lung Metastases: An Italian Sarcoma Group and Associazione Italiana Ematologia Oncologia Pediatrica Joint Study
Authors: Abate Massimo E. , Cammelli Silvia , Ronchi Letizia , Diletto Barbara , Gandola Lorenza , Paioli Anna , Longhi Alessandra , Palmerini Emanuela , Puma Nadia , Tamburini Angela , Mascarin Maurizio , Coassin Elisa , Prete Arcangelo , Asaftei Sebastian D. , Manzitti Carla , Bisogno Gianni , Pierobon Marta , Coccoli Luca , Capasso Mariella , Grignani Giovanni , Milano Giuseppe M. , Kiren Valentina , Fagioli Franca , Ferrari Stefano , Picci Piero , Carretta Elisa , Luksch Roberto
Published: June 2021

Purpose: To analyze toxicity and outcome predictors in Ewing sarcoma patients with lung metastases treated with busulfan and melphalan (BU-MEL) followed by whole-lung irradiation (WLI). Methods: This retrospective study included 68 lung metastatic Ewing Sarcoma patients who underwent WLI after BU-MEL with autologous stem cell transplantation, as part of two prospective and consecutive treatment protocols. WLI 12 Gy for <14 years old and 15 Gy for ≥14 years old patients were applied at least eight weeks after BU-MEL. Toxicity, overall survival (OS), event-free survival (EFS) and pulmonary relapse-free survival (PRFS) were estimated and analyzed. Results: After WLI, grade 1–2 and grade 3 clinical toxicity was reported in 16.2% and 5.9% patients, respectively. The five-year OS, EFS and PRFS with 95% confidence interval (CI) were 69.8% (57.1–79.3), 61.2% (48.4–71.7) and 70.5% (56.3–80.8), respectively. Patients with good histological necrosis of the primary tumor after neoadjuvant chemotherapy showed a significant decreased risk of pulmonary relapse or death compared to patients with poor histological necrosis. Conclusions: WLI at recommended doses and time interval after BU-MEL is feasible and might contribute to the disease control in Ewing sarcoma with lung metastases and responsive disease. Further studies are needed to explore the treatment stratification based on the histological response of the primary tumor.
Accurate Prognosis Prediction of Pancreatic Ductal Adenocarcinoma Using Integrated Clinico-Genomic Data of Endoscopic Ultrasound-Guided Fine Needle Biopsy
Authors: Park Joo Kyung , Kim Hyemin , Son Dae-Soon , Kim Nayoung K. D. , Sung Young Kyung , Cho Minseob , Lee Chung , Noh Dong Hyo , Lee Se-Hoon , Lee Kyu Taek , Lee Jong Kyun , Jang Kee-Taek , Park Woong-Yang , Lee Kwang Hyuck
Published: June 2021

The aim of this study was to investigate the clinical utility of minimal specimens acquired from endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) and perform targeted deep sequencing as a prognosis prediction tool for pancreatic ductal adenocarcinoma (PDAC). A total of 116 specimens with pathologically confirmed PDAC via EUS-FNB were tested using CancerSCAN® panel for a customized targeted deep sequencing. Clinical prognostic factors significantly associated with survival in PDACs were as follows: stage, tumor mass size, tumor location, metastasis, chemotherapy, and initial CA19-9 level. A total of 114 patients (98.3%) had at least a single genetic alteration, and no mutations were detected in two patients, although they were qualified for the targeted deep sequencing. The frequencies of major gene mutations responsible for PDACs were KRAS 90%, CDKN2A 31%, TP53 77%, and SMAD4 29%. A somatic point mutation of NF1, copy number alteration of SMAD4, and loss-of-function of CDKN2A were significantly associated genetic factors for overall survival. Moreover, BRCA2 point mutation was related to liver metastasis. Finally, a clinico-genomic model was developed to estimate the prognosis of patients with PDAC based on clinical parameters and genetic alterations affecting survival in patients; 20 single nucleotide variants and three copy number variations were selected. Targeted deep sequencing on minimal specimens of PDACs was performed, and it was applied to establish a clinico-genomic model for prognosis prediction.
Human Adipose-Derived Stromal/Stem Cell Culture and Analysis Methods for Adipose Tissue Modeling In Vitro: A Systematic Review
Authors: Gibler Peyton , Gimble Jeffrey , Hamel Katie , Rogers Emma , Henderson Michael , Wu Xiying , Olesky Spencer , Frazier Trivia
Published: June 2021

Human adipose-derived stromal/stem cells (hASC) are widely used for in vitro modeling of physiologically relevant human adipose tissue. These models are useful for the development of tissue constructs for soft tissue regeneration and 3-dimensional (3D) microphysiological systems (MPS) for drug discovery. In this systematic review, we report on the current state of hASC culture and assessment methods for adipose tissue engineering using 3D MPS. Our search efforts resulted in the identification of 184 independent records, of which 27 were determined to be most relevant to the goals of the present review. Our results demonstrate a lack of consensus on methods for hASC culture and assessment for the production of physiologically relevant in vitro models of human adipose tissue. Few studies have assessed the impact of different 3D culture conditions on hASC adipogenesis. Additionally, there has been a limited use of assays for characterizing the functionality of adipose tissue in vitro. Results from this study suggest the need for more standardized culture methods and further analysis on in vitro tissue functionality. These will be necessary to validate the utility of 3D MPS as an in vitro model to reduce, refine, and replace in vivo experiments in the drug discovery regulatory process.
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility
Authors: Gruber Teresa Mira , Mechsner Sylvia
Published: June 2021

Endometriosis (EM) and adenomyosis (AM) are common conditions with pain and infertility as the principal symptoms. The pathophysiology of pain in EM and AM comprises sensory and somatoform pain mechanisms. Over time, these may aggravate and lead to individual complex disease patterns if not diagnosed and treated. Despite the known facts, several years often pass between the onset of symptoms and diagnosis. Chronic pain disorders with changes on a neuronal level frequently arise and are linked to depressive disorders, with the process becoming a vicious cycle. Additionally, women with EM and AM suffer from sub- and infertility. Low fecundity rates are caused by anatomical changes in combination with behavioral changes in the sexual activity of women with chronic pain as well as local proinflammatory factors that not only decrease implantation rates but also promote early abortions.
An Extended Correlation Dimension of Complex Networks
Authors: Zhang Sheng , Lan Wenxiang , Dai Weikai , Wu Feng , Chen Caisen
Published: June 2021

Fractal and self-similarity are important characteristics of complex networks. The correlation dimension is one of the measures implemented to characterize the fractal nature of unweighted structures, but it has not been extended to weighted networks. In this paper, the correlation dimension is extended to the weighted networks. The proposed method uses edge-weights accumulation to obtain scale distances. It can be used not only for weighted networks but also for unweighted networks. We selected six weighted networks, including two synthetic fractal networks and four real-world networks, to validate it. The results show that the proposed method was effective for the fractal scaling analysis of weighted complex networks. Meanwhile, this method was used to analyze the fractal properties of the Newman–Watts (NW) unweighted small-world networks. Compared with other fractal dimensions, the correlation dimension is more suitable for the quantitative analysis of small-world effects.
Evaluation of Mechanical and Energetic Properties of the Forest Residues Shredded Chips during Briquetting Process
Authors: Roman Kamil , Barwicki Jan , Rzodkiewicz Witold , Dawidowski Mariusz
Published: June 2021

The briquetting process is one of methods of solid biofuel production. During the briquetting of raw material, it can be noticed that material is viscoelastic, and reflects the effect on the volume and the final effect of the agglomerate during mentioned treatment. The research aimed to evaluate the mechanical and energetic properties of shredded pine forest residues during the briquetting process. The shredded fragments of the forest residues were compacted by the principal stresses with determination of the energy value consumed during the briquetting process. Tests were carried out using a specially designed compacting tube, with additional equipment directly mounted on the testing machine. The compaction process was carried out using the presented material and through continuous monitoring of the process parameters. During the study, it was estimated that the moisture content of the compacted material should be equal from 10 to 15%. The calculated average value of the unit energy consumption during the briquetting process (WB) was equal to 0.14 MJ·kg−1. In future research, the mathematical model can serve as an algorithm in a computer program in order to calculate the flow of biomass in the extrusion process.
Spirituality and Conflict in Healthcare: The History of the Canadian Baptists and Medical Mission in Orissa, 1900–1970
Authors: Basu Roy Tiasa
Published: June 2021

It was from the middle of the eighteenth century that discussions regarding the strategies taken up by the Protestant missionaries to propagate the Gospel generated the issue of healthcare and medical facilities among people in India. Medical mission, which hitherto was not considered, started to gain importance and reaped positive results in terms of curing individuals and its trustworthiness among tribes residing in the frontier regions. However, this developed a separatist religious identity among the population, which apparently did not appear lethal, but later culminated in the fragmentation and impeachment of solidarity among the adivais (tribal) and vengeance from the Hindu population. This article will show how the Canadian Baptist Mission, with its primary aim of spreading the Kingdom of God among the tribal Savaras in the Ganjam district of Orissa, undertook measures for serving health issues and provided medical facilities to both the caste Oriyas and the tribal Savaras. Although medical activities oriented towards philanthropy and physical well-being, medical mission was not limited to healing illness and caring for all, but also extended to spreading the word of God and influencing the people to embrace Christianity as well, which invited political troubles into the region.
The Impact of Age, Gender and Technical Experience on Three Motor Coordination Skills in Children Practicing Taekwondo
Authors: Boutios Stefanos , Fiorilli Giovanni , Buonsenso Andrea , Daniilidis Panagiotis , Centorbi Marco , Intrieri Mariano , di Cagno Alessandra
Published: June 2021

The study aim was to investigate the age, gender and technical level on motor coordination abilities of Taekwondo children. One hundred and fifteen children (83 male, 32 female), aged 7.76 ± 1.71 years, divided in three different groups, under 8 (5–7 years), under 10 (8–9 years) and under 12 (10–11 years), underwent three coordination skills tests: the ruler drop test (RDT), assessing visual reaction time, the hexagonal test (HT), assessing agility, and the target kick test (TKT), assessing kicking ability. MANOVA showed significant gender differences for TKT, in which females showed higher scores than males (p = 0.033). Significant differences were found in HT and TKT, where the under 12 group showed higher scores than younger athletes (p < 0.001). No differences amongst different age groups were found in RDT, showing that this could be a good predictor of Taekwondo performance, assessed at an early stage. High-level athletes showed better scores in all the tests than the low levels, as it was expected. Coordinative performance improves with age and is positively influenced by practicing a sports activity. The predisposition to a particular sport with a well-planned training may lead to a motor proficiency comparable to that reached by older athletes and better than same-age athletes.
A Review on Bacterial Contribution to Lignocellulose Breakdown into Useful Bio-Products
Authors: Chukwuma Ogechukwu Bose , Rafatullah Mohd , Tajarudin Husnul Azan , Ismail Norli
Published: June 2021

Discovering novel bacterial strains might be the link to unlocking the value in lignocellulosic bio-refinery as we strive to find alternative and cleaner sources of energy. Bacteria display promise in lignocellulolytic breakdown because of their innate ability to adapt and grow under both optimum and extreme conditions. This versatility of bacterial strains is being harnessed, with qualities like adapting to various temperature, aero tolerance, and nutrient availability driving the use of bacteria in bio-refinery studies. Their flexible nature holds exciting promise in biotechnology, but despite recent pointers to a greener edge in the pretreatment of lignocellulose biomass and lignocellulose-driven bioconversion to value-added products, the cost of adoption and subsequent scaling up industrially still pose challenges to their adoption. However, recent studies have seen the use of co-culture, co-digestion, and bioengineering to overcome identified setbacks to using bacterial strains to breakdown lignocellulose into its major polymers and then to useful products ranging from ethanol, enzymes, biodiesel, bioflocculants, and many others. In this review, research on bacteria involved in lignocellulose breakdown is reviewed and summarized to provide background for further research. Future perspectives are explored as bacteria have a role to play in the adoption of greener energy alternatives using lignocellulosic biomass.
Psychometric Properties of the Polish Version of the Parental Feelings Inventory
Authors: Fijałkowska Dominika , Bielawska-Batorowicz Eleonora
Published: June 2021

Previous reports from international literature have emphasized the specific nature of the feelings experienced by parents related to their role, differentiating them from other emotional states. Researchers highlighted the role of parental emotions in parent–child interaction and child development. The aim of the present study was to create the Polish version of the Parental Feelings Inventory (PFI), which is a rating scale designed to determine parental emotions within the parenting role, and to assess its psychometric properties. The participants included 191 parents (102 mothers and 89 fathers) aged 22 to 55 years (M = 37.18, SD = 6.85), both parents of healthy children and those of children with chronic diseases or disabilities. All participants completed the translated PFI questionnaire, Parental Attitude Scale (SPR), SUPIN S20 and SUPIN C20. The results support a three-factor solution (Angry, Happy, and Anxious/Sad) and a structure of 22 items for the PFI. The internal consistency for the complete scale was α = 0.78 for mothers and α = 0.76 for fathers. Cronbach’s α coefficients for individual factors for the Polish version were good: all above 0.80. The Polish PFI correlated with measures of parental attitudes and positive/negative affect; in addition, the Polish version confirms the basic psychometric criteria of the original and yields the same results. Therefore, the Polish version of the PFI is a valid and reliable tool for measuring parental feelings and can be successfully used as a measure of emotional experiences in the parenting role.
Trends in Suicide Mortality in 10 Years around the Great East Japan Earthquake: Analysis of Evacuation and Non-Evacuation Areas in Fukushima Prefecture
Authors: Kuroda Yujiro , Orui Masatsugu , Hori Arinobu
Published: June 2021

This study analyzed the suicide mortality rate in 12 municipalities in Fukushima Prefecture designated as evacuation areas following the 2011 nuclear disaster. Changes in suicide rates were examined using an exponential smoothing time series model. In the evacuation areas, the suicide rate of men increased immediately after the disaster and then decreased from 47.8 to 23.1 per 100,000 during about 1½ years after the disaster. However, with the lifting of the evacuation order, it again exceeded that of non-evacuation areas and continued to do so for the next 3 years. On the other hand, the suicide rate in women in the evacuation areas increased later than that in men. These results indicate the need for continuous support following the lifting of the evacuation order. In addition, it is necessary to enhance social networks, which continue to confer protection, because of the isolation of the elderly as highlighted in our previous study.
Assessment of PM2.5 Exposure during Cycle Trips in The Netherlands Using Low-Cost Sensors
Authors: Wesseling Joost , Hendricx Wouter , de Ruiter Henri , van Ratingen Sjoerd , Drukker Derko , Huitema Maaike , Schouwenaar Claar , Janssen Geert , van Aken Stephen , Smeenk Jan , Hof Arjen , Tielemans Erik
Published: June 2021

Air pollution, especially fine particulate matter (PM2.5), is a major environmental risk factor for human health in Europe. Monitoring of air quality takes place using expensive reference stations. Low-cost sensors are a promising addition to this official monitoring network as they add spatial and temporal resolution at low cost. Moreover, low-cost sensors might allow for better characterization of personal exposure to PM2.5. In this study, we use 500 dust (PM2.5) sensors mounted on bicycles to estimate typical PM2.5 levels to which cyclists are exposed in the province of Utrecht, the Netherlands, in the year 2020. We use co-located sensors at reference stations to calibrate and validate the mobile sensor data. We estimate that the average exposure to traffic related PM2.5, on top of background concentrations, is approximately 2 μg/m3. Our results suggest that cyclists close to major roads have a small, but consistently higher exposure to PM2.5 compared to routes with less traffic. The results allow for a detailed spatial representation of PM2.5 concentrations and show that choosing a different cycle route might lead to a lower exposure to PM2.5. Finally, we conclude that the use of mobile, low-cost sensors is a promising method to estimate exposure to air pollution.
Infectious Respiratory Diseases Decreased during the COVID-19 Pandemic in South Korea
Authors: Kim Da Hae , Nguyen Thi Mai , Kim Jin Hee
Published: June 2021

Infectious respiratory diseases are highly contagious and very common, and thus can be considered as one of the leading causes of morbidity and mortality worldwide. We followed up the incidence rates (IRs) of eight infectious respiratory diseases, including chickenpox, measles, pertussis, mumps, invasive pneumococcal disease, scarlet fever, rubella, and meningococcal disease, after COVID-19 mitigation measures were implemented in South Korea, and then compared those with the IRs in the corresponding periods in the previous 3 years. Overall, the IRs of these diseases before and after age- or sex-standardization significantly decreased in the intervention period compared with the pre-intervention periods (p < 0.05 for all eight diseases). However, the difference in the IRs of all eight diseases between the IRs before and after age-standardization was significant (p < 0.05 for all periods), while it was not significant with regard to sex-standardization. The incidence rate ratios for eight diseases in the pre-intervention period compared with the intervention period ranged from 3.1 to 4.1. These results showed the positive effects of the mitigation measures on preventing the development of respiratory infectious diseases, regardless of age or sex, but we need to consider the age-structure of the population to calculate the effect size. In the future, some of these measures could be applied nationwide to prevent the occurrence or to reduce the transmission during outbreaks of these infections. This study provides evidence for strengthening the infectious disease management policies in South Korea.
Favorable Lip and Oral Cancer Mortality-to-Incidence Ratios in Countries with High Human Development Index and Expenditures on Health
Authors: Sung Wen-Wei , Hsu Yong-Chen , Dong Chen , Chen Ying-Ching , Chao Yu-Chi , Chen Chih-Jung
Published: June 2021

Background: The incidence rates of lip and oral cancer have continued to increase, and prognosis is associated with a country’s socioeconomic status. The mortality-to-incidence ratio (MIR) is a reasonable indicator of disparities in cancer screening and treatment. In this study, we aimed to understand the association between economic status and cancer prognosis. Methods: Data were obtained from the Global Cancer Observatory (GLOBOCAN) and the World Health Organization (WHO). The MIRs were compared to evaluate the correlation with the human development index (HDI), the current health expenditure (CHE), and the ratio of CHE over gross domestic product (CHE/GDP) disparities via Spearman’s rank correlation coefficient. Results: The results showed that Asia had the most cases and deaths. In addition, they showed a significant association (p < 0.001, p = 0.005, and p < 0.001, respectively) of the crude rate (CR) of incidence with the HDI, the CHE, and the CHE/GDP. However, their associations with mortality rate (p = 0.303, p = 0.997, and p = 0.101) were not significant. Regarding the correlation of the MIRs, the results revealed a significant association with the HDI, the CHE, and the CHE/GDP (p < 0.001, p < 0.001, and p < 0.001, respectively). Conclusion: Countries with higher HDI, CHE per capita, and CHE/GDP tend to have lower MIRs, which indicates favorable clinical outcomes.
The Healthcare Sector Employer’s Duty of Care: Implications for Worker Well-Being
Authors: McDiarmid Melissa , Condon Marian , Gaitens Joanna
Published: June 2021

Pandemic diseases of this century have differentially targeted healthcare workers globally. These infections include Severe Acute Respiratory Syndrome SARS, the Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) and Ebola. The COVID-19 pandemic has continued this pattern, putting healthcare workers at extreme risk. Just as healthcare workers have historically been committed to the service of their patients, providing needed care, termed their “duty of care”, so too do healthcare employers have a similar ethical duty to provide care toward their employees arising from historical common law requirements. This paper reports on results of a narrative review performed to assess COVID-19 exposure and disease development in healthcare workers as a function of employer duty of care program elements adopted in the workplace. Significant duty of care deficiencies reported early in the pandemic most commonly involved lack of personal protective equipment (PPE) availability. Beyond worker safety, we also provide evidence that an additional benefit of employer duty of care actions is a greater sense of employee well-being, thus aiding in the prevention of healthcare worker burnout.
The Pattern of Mandibular Third Molar Impaction and Assessment of Surgery Difficulty: A Retrospective Study of Radiographs in East Baltic Population
Authors: Jaroń Aleksandra , Trybek Grzegorz
Published: June 2021

Classifications of impacted teeth allow defining the type and degree of retention, as well as assessing the degree of difficulty of the procedure. The aim of this study was to conduct retrospective analysis of the degree of retention and difficulty in the surgical removal of impacted mandibular third molars in the clinical material of the Department of Oral Surgery in 2013–2018. This study included 1585 dental panoramic radiographs of patients of the Department of Oral Surgery, who reported in 2013–2018, in order to perform surgical removal of the impacted mandibular third molar. Based on dental panoramic radiographs, the degree of retention was determined based on classifications according to Winter, according to Pell and Gregory, according to Tetsch and Wagner, and according to Asanami and Kasazaki. The difficulty of the procedure was also assessed based on the Pederson index. The most common types of lower wisdom tooth impaction are as follows: in Winter’s classification, mesial-angular impaction; in Tetsch and Wagner’s classification, oblique medial-angular impaction; in Pell and Gregory’s classification, impaction grade 2A; and in Asanami and Kasazaki’s classification, 3A and anterior inclination. In most cases of surgical removal of an impacted tooth, the anticipated difficulty of the procedure was rated as very difficult.
Medical Liability: Review of a Whole Year of Judgments of the Civil Court of Rome
Authors: Treglia Michele , Pallocci Margherita , Passalacqua Pierluigi , Giammatteo Jacopo , De Luca Lucilla , Mauriello Silvestro , Cisterna Alberto Michele , Marsella Luigi Tonino
Published: June 2021

Background: Complaints about medical malpractice have increased over time in Italy, as well as other countries around the world. This scenario, perceived by some as a “malpractice crisis”, is a subject of debate in health law and medical law. The costs arising from medical liability lawsuits weigh not only on individual professionals but also on the budgets of healthcare facilities, many of which in Italy are supported by public funds. A full understanding of the phenomenon of medical malpractice appears necessary in order to manage this spreading issue and possibly to reduce the health liability costs. Methods: The retrospective review concerned all the judgments drawn up by the Judges of the Civil Court of Rome, XIII Chamber (competent and specialized section for professional liability trials) published between January 2018 and February 2019. Results: The analysis of data concerning the involved parties showed that in 84.6% of the judgments taken into account, one or more health facilities were sued, while in 58.2% of cases, one or more health workers were present among the defendants. When healthcare providers are the only ones to be summoned, it is dentists and aesthetic doctors/plastic surgeons who undergo most of the claims. In the overall period analyzed, the amount paid was 23,489,254.08 EUR with an average of 163,119.82 EUR. Conclusion: The evidence provided by the reported data is a useful tool to understand medical malpractice in Italy, especially with regard to the occurrence of the phenomenon at a legal level, an aspect still hardly mentioned by existing literature.
Degradation of Polyvinyl Alcohol in US Wastewater Treatment Plants and Subsequent Nationwide Emission Estimate
Authors: Rolsky Charles , Kelkar Varun
Published: June 2021

Polyvinyl alcohol (PVA) is a water-soluble plastic commercially used in laundry and dish detergent pods (LDPs) for which a complete understanding of its fate in the environment and subsequent consequences is lacking. The objective of this study was to estimate the US nationwide emissions of PVA resulting from domestic use of LDPs, corroborated by a nationwide, online consumer survey and a literature review of its fate within conventional wastewater treatment plants (WWTPs). Peer-reviewed publications focusing on the degradation of PVA in critical processes of WWTPs were shortlisted as a part of the literature review, and subsequent degradation data was extracted and applied to a model with a set of assumptions. Survey and model results estimated that approximately 17,200 ± 5000 metric ton units per year (mtu/yr) of PVA are used from LDPs in the US, with 10,500 ± 3000 mtu/yr reaching WWTPs. Literature review data, when incorporated into our model, resulted in ~61% of PVA ending up in the environment via the sludge route and ~15.7% via the aqueous phase. PVA presence in the environment, regardless of its matrix, is a threat to the ecosystem due to the potential mobilization of heavy metals and other hydrophilic contaminants.
Evaluation and Future Projection of Extreme Climate Events in the Yellow River Basin and Yangtze River Basin in China Using Ensembled CMIP5 Models Data
Authors: Niu Zigeng , Feng Lan , Chen Xinxin , Yi Xiuping
Published: June 2021

The Yellow River Basin (YLRB) and Yangtze River Basin (YZRB) are heavily populated, important grain-producing areas in China, and they are sensitive to climate change. In order to study the temporal and spatial distribution of extreme climate events in the two river basins, seven extreme temperature indices and seven extreme precipitation indices were projected for the periods of 2010–2039, 2040–2069, and 2070–2099 using data from 16 Coupled Model Intercomparison Project Phase 5 (CMIP5) models, and the delta change and reliability ensemble averaging (REA) methods were applied to obtain more robust ensemble values. First, the present evaluation indicated that the simulations satisfactorily reproduced the spatial distribution of temperature extremes, and the spatial distribution of precipitation extremes was generally suitably captured. Next, the REA values were adopted to conduct projections under different representative concentration pathway (RCP) scenarios (i.e., RCP4.5, and RCP8.5) in the 21st century. Warming extremes were projected to increase while cold events were projected to decrease, particularly on the eastern Tibetan Plateau, the Loess Plateau, and the lower reaches of the YZRB. In addition, the number of wet days (CWD) was projected to decrease in most regions of the two basins, but the highest five-day precipitation (Rx5day) and precipitation intensity (SDII) index values were projected to increase in the YZRB. The number of consecutive dry days (CDD) was projected to decrease in the northern and western regions of the two basins. Specifically, the warming trends in the two basins were correlated with altitude and atmospheric circulation patterns, and the wetting trends were related to the atmospheric water vapor content increases in summer and the strength of external radiative forcing. Notably, the magnitude of the changes in the extreme climate events was projected to increase with increasing warming targets, especially under the RCP8.5 scenario.