bluuebunny/crossref_metadata_2025 huggingface dataset:
GAGACHAT КАК ОДНА ИЗ КОММУНИКАТИВНЫХ ФОРМ СЕТЕВОГО ФОЛЬКЛОРА НА ПРИМЕРЕ АНГЛОЯЗЫЧНОГО ИНСТАГРАМ-АККАУНТА ЛЕДИ ГАГИ
Authors: Yukhmina Elena Aleksandrovna , Obvintseva Nadezhda Valerevna
Published: February 2020

Цель. В статье рассматривается «виртуальный флэшмоб» (на примере комментариев к англоязычному посту) как одна из коммуникативных форм сетевого фольклора с целью описания его функций и форм проявления, а также классификации комментариев по тематическим группам и анализа их основных лингвистических особенностей. Эмпирическую базу настоящего исследования составили комментарии активных пользователей социальной сети Инстаграм. Теоретическая база – труды российских и зарубежных исследователей по виртуальному фольклору Nathan Chandler, Simon J. Bronner, Trevor J. Blank, В.П. Рукомойниковой, Ю.М. Соколова, А.С. Каргина и др.Метод или методология проведения работы. В исследовании использовались методы наблюдения и описания, а также структурно-семантического и интерпретационного анализа с элементами прагмалингвистического анализа.Результаты. Новизна данной работы состоит в том, что здесь представлен анализ новейшего языкового феномена – «виртуального флэшмоба» в социальной сети Инстаграм. Составлена тематическая классификация комментариев к англоязычному посту, проанализирован язык комментариев с точки зрения фольклорных особенностей, рассмотрены прецедентные феномены, выявлено место комментариев в общей типологии сетевого фольклора с опорой на проведенное ранее исследование авторов.Область применения результатов. Результаты исследования могут быть применены в сфере PR-коммуникации, для проведения лингвистических исследований.
РЕПРЕЗЕНТАЦИЯ КОНЦЕПТА «СТРАХ» В АНГЛОЯЗЫЧНОМ РЕКЛАМНОМ ДИСКУРСЕ
Authors: Vorobyova Anna Evgenevna , Fedyunina Inna Eduardovna , Belozerova Marina Sergeevna
Published: February 2020

В статье описываются способы репрезентации концепта «страх» в современном англоязычном рекламном дискурсе, а также выявляется функциональная эффективность и речевоздействующий потенциал маркетинга, апеллирующего к эмоциям реципиентов.Цель исследования состоит в выявлении и анализе ресурсов суггестии, базирующихся на страхе и используемых копирайтерами для воздействия на психоэмоциональное состояние целевой аудитории. Предметом изучения выступают специфически маркированные элементы англоязычных текстов рекламных билбордов, призванные имплицитно воздействовать на поведение реципиентов и способствовать реализации целеустановки маркетологов. В настоящей работе для более целостного взгляда на феномен современного рекламного дискурса предпринята попытка интеграции знаний лингвистики и психологии.Методы исследования определяются задачами исследования и включают общенаучные методы анализа и синтеза, когнитивного анализа, контент-анализа, метода концептуального анализа, метода социологического опроса, а также психолингвистического метода свободного ассоциативного эксперимента.Наиболее значимыми результатами исследования представляются выводы о том, что в рекламном типе дискурса концепт «страх» выступает инструментом эффективного воздействия на языковое сознание целевой аудитории, но градация интенсивности воздействия варьируется в разных лингвокультурах. Способы речевого воздействия определяются прагматическими установками копирайтеров и проявляются на лингвистическом и экстралингвистическом уровне.Область применения результатов. Представленные положения и выводы могут представлять интерес не только для эмотиологии, но и в плане практического применения при составлении рекламных текстов различной прагматической направленности.
IMPLEMENTATION OF EDUPRENEURSHIP THROUGH THE TEACHING FACTORY IN VOCATIONAL HIGH SCHOOL OF HOTEL ACCOMMODATION: CASE STUDY AT SMK N 6 YOGYAKARTA
Authors: Kuat Tri
Published: February 2020

The purpose of this study is to know, to describe, and to analyze the implementation of edupreneurship through teaching factory in the vocational high school (SMK) majoring in hotel accommodation program skill. The research method used in this research is the qualitative method. This method is intended to know deeply in the implementation of edupreneurship through teaching factory in SMK. This research started with the observation of edupreneurship activity through teaching factory at SMK N 6 Yogyakarta. The data was collected by conducting in-depth interviews with informants who are directly involved in edupreneurship activities. The result of this research is the implementation of edupreneurship through teaching factory in terms of learning, there is commitment and basic principle which run by the school but not yet optimal. There are still significant obstacles, especially related to the work culture that is applied not in accordance with the procedures of business and industry (DUDI), educators who have not understood the culture of DUDI, facilities, and infrastructure that do not meet the DUDI standards, the cooperation between SMK and DUDI is still weak, and the regulation of the Supreme Audit Agency (BPK) which requires the use of state-owned goods as a form of state income.
A centralised complex venous service model in an NHS hospital
Authors: Lim Chung Sim , Halliday Charlotte , Harvey Vanessa , Quintana Belen , Thulasidasan Narayanan , Black Stephen
Published: February 2020

Background/aims

Recent evidence supporting the efficacy and safety of deep venous interventions is likely to increase the demand for complex venous services on the NHS. This study aimed to analyse the clinical activity of a tertiary-referral complex venous service model and the estimated costs in an NHS hospital over a period of 1 year.

Methods

The clinical activity, admission type and treatment cost of all the patients managed by an NHS complex venous service between 1 February 2015 and 31 May 2016 were reviewed.

Findings

The mean monthly demand for outpatient services for new referrals and follow-ups was 22 and 82.9 respectively. The total number of admissions was 328 (mean of 27.3 admissions per month), with the outpatient cost totaling at £141 888 in 1 year.

Conclusions

The analysis suggests that the current complex venous service model is feasible and potentially sustainable in an NHS hospital.
The impact of electronic medical records' functions on the quality of health services
Authors: Sharikh Ekhlas Abu , Shannak Rifat , Suifan Taghrid , Ayaad Omar
Published: February 2020

Background/aims

Electronic medical records are the most common E-health application and they are starting to be implemented worldwide. In Jordan, the introduction of electronic medical records helps to improve quality and reduce service costs. This article aimed to examine how the implementation of electronic medical records impacted health service quality in Jordan.

Methods

A cross-sectional study was conducted in Jordanian hospitals that used electronic medical records. The data were collected using a self-administered questionnaire, which 582 healthcare professionals returned. The Statistical Package for Social Sciences was used to perform descriptive and statistical analyses.

Results

The results showed that there was a statistically significant impact when using electronic medical records. These findings were divided into two categories: function (practice management, communication, documentation or data entry, and medication management) and on the quality of services (reliability, responsiveness, assurance, and empathy).

Conclusions

The research indicated that using electronic medical records improved the quality of health services.
Approach to an incidental adrenal mass
Authors: Black Vicki
Published: February 2020

Adrenal glands represent important endocrine organs. Disorders of these can present in many vague, often non-specific ways; this presents a dilemma for the clinician when an abnormal adrenal gland is detected on imaging. This article aims to explore the evidence for approach to adrenal masses in the dog and cat, including defining an adrenal gland mass, the logical approach to the mass, and treatment options.
Adult-child relations in neoliberal times: insights from a dialogue across childhood and parenting culture studies
Authors: Rosen Rachel , Faircloth Charlotte
Published: February 2020

In this introductory article for the special issue ‘Childhood, Parenting Culture and Adult-Child Relations in Global Perspectives’, we provide an overview of our fields of study (childhood studies and parenting culture studies) by placing them in dialogue. We do so as a basis for drawing out themes emerging from the special issue, in order to explore potential synergies and open broader debates. We begin by tracing moves towards more relational approaches in the social sciences indicating their epistemological and methodological implications. Relational thinking provides a basis for countering antagonistic positionings of children and adults, allowing for circulations of childhood and parenting cultures to be interrogated in relation to new and enduring forms of inequity and changing state-family-capital relations. We suggest that this complicates existing conceptualisations of neoliberalisation while drawing attention to the need for further interrogation of the transnational nature of adult-child relations.
Non-Originalism Differently: the Obligation of the Legislator to Respond to Changing Conditions
Authors: Kokešová Jana
Published: February 2020

The question that the paper seeks to answer is formulated through reflections on the is-sues of non-originalism. Non-originalism refers to an approach to the interpretation of the Constitution where the text of the Constitution adapts to new conditions without any formal change. This approach is applied by courts which, in the light of new circumstances, interpret the Constitution in a different way. The question is whether the same approach should also be applied by the legislator. Should it be the legislator who monitors whether the Constitution has changed in substance as a result of changes in society and that some existing statutes thus have become unconstitutional? The paper concludes that the legisla-tor has an obligation to monitor and respond to such changes by amending or abolishing certain statutes or by adopting new ones. If the legislator fails to respond, then his behav-iour – inaction – is unconstitutional. However, the paper does not claim that the legislator must respond to all the changes in society, but only to those that are significant and obvi-ous. The legislator is understood as an institution, not as a member of the legislative body (based on the theory of the legislative intent). However, the institution of the legislator is a human creation and composed of individuals, and it is their knowledge that makes up the knowledge of the legislator. And it is precisely their possibilities that determine the bound-aries of what the legislator should know. In this text, the creation of law is understood as communication between the legislator, who is the author of statutes, and public bodies, who interpret and apply them. As with any communication, context is what determines it. The legislator’s obligations are derived from the content of the context, its function, and its essential position in communication.
Stability of an additive-quadratic-quartic functional equation
Authors: Kim Gwang Hui , Lee Yang-Hi
Published: February 2020

In this paper, we investigate the stability of an additive-quadratic-quartic functional equation

$$\begin{align*}f(x+2y)& +f(x-2y)-2f(x+y)-2f(-x- y)-2f(x-y)-2f(y-x)\nonumber \\ &+4f(-x)+ 2f(x)-f(2y)-f(-2y)+4f(y)+4f(-y)=0 \end{align*}$$

by the direct method in the sense of Găvruta.
Records and Transformations of Memories in the Cultural Landscape of Idomeni (Kilkis, Northern Greece)
Authors: Chatzitoulousis Stamatis , Vlasidis Vlasis , Sarris Apostolos , Efkleidou Kalliopi , Kotjabopoulou Eleni , Papadopoulos Nikos , Argyriou Nasos , Donati Jamie , Manataki Meropi , Trapero-Fernandez Pedro
Published: February 2020

Following recent excavations and geophysical prospection at Idomeni in the Kilkis prefecture of Northern Greece, this paper attempts to reconstruct through digital means, the tangible and intangible vestiges of historical episodes that come together to form multiple narratives of a diachronically terra incognita site, gradually unlocking its hidden secrets. The digital documentation and processing, with the use of Geographical Information Systems (GIS), of the spatial remains associated with historical episodes demonstrate the ways in which space at Idomeni was used within a multifaceted, diachronic framework. It is a place that is constantly being transformed over the past 7000 years from a seemingly “peaceful” agricultural community during the Neolithic period to a burial ground for a still invisible Middle Byzantine settlement, and finally, as a place of violence having been one of the battlefields of the First World War. The story of Idomeni has only recently been concluded as the theatre of a dramatic influx of modern refugees. Thus, the “multilayered” identity of a mnemonic place with various representations of the past unfolds: on one hand the distant eras, such as the still unknown Neolithic and Middle Byzantine period, and on the other, the relatively recent “traumatic” (war-related) past. Within the specific historical context of the First World War, this paper discusses the management of memories of locals and non-locals, e.g. the disappearance of entire settlements, or the emergence of new toponyms related to the protagonists and their actions during the war in the area of Idomeni remaining in the memory of locals today.
ДОЦІЛЬНІСТЬ СКЛАДОВИХ МОДЕЛІ СОЦІАЛЬНОЇ АДАПТОВАНОСТІ СТАРШИХ ДОШКІЛЬНИКІВ З ОСОБЛИВИМИ ПОТРЕБАМИ
Authors: Chernykh Larysa
Published: February 2020

У статті розкрито особливості соціальної адаптованості дітей старшого дошкільного віку з порушенням зору, слуху, мовлення. Висвітлено основні складові створеної моделі соціальної адап­т­о­ва­нос­ті старших дошкільників з особливими потребами. Проведено факторизацію її складових та дове­де­но доцільність створення моделі соціальної адаптованості старших дошкільників з особливими по­тре­бами.
Application of Fractal Growth Patterns in Housing Layout Design
Authors: Subhadha Battina
Published: February 2020

In early phases of design, during the process of form-exploration, architects -- knowingly or unknowingly -- have used mathematics as their guiding tool to evolve a formal methodology of design. Fundamental compositional principles such as symmetry, rhythm and proportion are based on speciﬁc mathematical underpinnings. However, very often the designer comes across a situation where these underlying mathematical principles need to be overlapped or interfaced. Applying fractal concepts to the order can accommodate this complex diversity. Fractals allow us to provide a combination of order and surprise in a rhythmic composition using a speciﬁc mathematical geometry. Fractals are typically unit-based and, can thus allow exploration in architectural designs which have a ‘unit’ as a fundamental issue or necessity. The design of housing layout stands out prominently among such architectural problems and, can thus be one such instance in which fractals may be used as a design tool. Commonly seen organisational patterns in housing layout designs create rigidity and monotony, while others like clustered groups are too inconsistent and can create disorder. The research tries applying fractal ordering principles to strike a balance between these extremes by creating an orderly arrangement of houses with an underlying variation in the pattern. The traditional processes of creating housing layouts is quite cumbersome. With the mathematical power of computers, fractal ordering principles are used as Iterative functions to generate multiple design options. The research investigates the potential of the emergent patterns of fractals as an organisational principle in designing housing layouts, while limiting it based on site constraints, size and the transforming rules. In doing so, the objective is to explore the computational and mathematical basis of repetitive patterns in architectural order and compositions. The study also aims at developing a computer application, based on algorithms using fractals, which offers capabilities as a conceptual and organisational tool for a housing layout. The application is implemented, tested and its results are demonstrated using a live terrain data.
Impact of British Raj on the Education System in India: The Process of Modernization in the Princely States of India – The case of Mohindra College, Patiala
Authors: Kanika Bansal
Published: February 2020

British rule is said to have been responsible for the modernization witnessed in the Indian civilization. The impact of this process was quiet evident from the changes adopted by the Indians in their life style, thinking processes, attires, food and education. Besides the advancements made in the spheres of roads, transports, postal services etc, their rule acted as a significant period of transition from the indigenous style of education to western education. The foundations were laid by the East India Company and the Christian Missionaries to employ Indians for administrative tasks as well as to serve their political, economical and colonial interests. Originally the access to education was limited to the royal families, as the British were of the opinion that Indians could become aware of their rights and positions and protest against their Raj posing a threat to the British establishment in India. Lord Curzon’s efforts in the 20th century gave way to spread of higher education within the masses and channelized Indian education system. However the rulers of the Princely States in of India who were granted autonomy by the British to manage their own kingdoms acted as major agents to undertake the social and educational reforms within their territories. With the spread of education from elementary to higher levels, many new schools, universities and other institutions were developed during this period which are symbols of educational advancement as well as hold high architectural merit. Patiala, aprime princely state is a well known academic centre also important for its rich culture since the British Raj. Education in Patiala originated under the Maharajas with the opening of the school of languages in 1860A.D. With the introduction of Mahindra College (the first Degree College in a city) in 1870, became came an important educational centre. It was the only college between Delhi and Lahore for a long time that promoted contemporary higher learning in Northern India. The historic college building represents an aesthetic mix of regional interpretation of Indo-Saracenic style of architecture. Later on many educational institutes catering to medical facilities, sports education etc. was set up in this princely state. This paper is thus an attempt to explore the education reforms during the British Raj, the changes that happened and their triggers. It also brings out reforms initiated in Princely States specifically Patiala as a seat of learning and a detailed study of the Mohindra College, Patiala, that represents an excellent example of educational institutions developed during the 19th century. The present study was done as a part of an academic project undertaken during Masters of Architecture under the able guidance of Prof Kiran Joshi..
БІОЛОГІЧНІ СПОСОБИ ЗАХИСТУ СТЕПОВОИХ ЗЕМЕЛЬ ВІД ЕРОЗІЙНИХ ПРОЦЕСІВ
Authors: Horeiko V. A.
Published: February 2020

Розглянуто наукові питання використання біологічних способів захисту степо-вих земель від ерозійних процесів і сучасного стану різноманіття лісових екосистемстепу України. Розроблено приорітетні методи підвищення продуктивності лісовихекосистем з метою досягнення високого меліоративного ефекту та захисту ґрунтіввід ерозії.
Os desafios da gestão territorial na proteção básica em uma metrópole
Authors: Souza Soraia Pereira de , Bronzo Carla
Published: February 2020

Resumo: O artigo analisa a gestão territorial desenvolvida pelos Centros de Referência de Assistência Social (Cras) em Belo Horizonte. A pesquisa utiliza abordagem quanti e quali, com dados coletados via questionários dirigido aos coordenadores dos 34 equipamentos no município, identificando os fatores e condicionantes que incidem na atuação dos Cras enquanto coordenadores da gestão territorial em seus territórios de abrangência e sistematiza os principais desafios para a efetividade dessa intervenção.
De Schwarzschild a Newton
Authors: Soares Domingos
Published: February 2020

Resumo A única solução exata das equações da Teoria da Relatividade Geral de reconhecida aplicabilidade prática foi obtida por Karl Schwarzschild em 1916. No limite de campo fraco ela se reduz à lei de gravitação de Newton. Apresento alguns aspectos da gravitação de Schwarzschild e mostro a sua redução à lei de gravitação clássica.
Fermentative characteristics and nutritional value of sugarcane silage added with two types of urea
Authors: Sousa-Alves Wagner , Rigueira João-Paulo S , Almeida-Moura Marielly M , De-Jesus Diego L S , Monção Flávio P , Rocha-Júnior Vicente R , Aspiazú Ignácio , De-Jesus Nathália G , De-Melo Jozélia A R , Da-Silva Marcos F P
Published: February 2020

Background: Dry matter (DM) loss is high in sugarcane silage due to its high content of soluble carbohydrates which favors yeast growth and ethanol production, thus reducing the nutritional value of the preserved forage. Objective: To determine the effect of adding two types of urea at two concentration levels to sugarcane silage on the nutritional value and fermentative characteristics of the silage. Methods: A completely randomized 2×2+1 factorial design was used, based on two types of urea (conventional and protected), two urea concentration (0.5 and 1.0% of the natural matter), and a control (sugarcane silage with no additives). Six replicates were used. The mixture was placed in PVC silos and opened after 60 days. Results: There was no difference in DM content or effluent losses by the addition of urea. In regards to neutral detergent fiber, acid detergent fiber, and lignin, decreased levels were observed compared to the control, regardless of urea type. Urea type and concentration had an effect on ammoniacal nitrogen content, with higher values for conventional urea, but not affecting the pH. The addition of urea to sugarcane silage reduced gas losses and raised the levels of crude protein, ether extract, and effective degradability. Conclusion: Adding protected or conventional urea at 1% of natural matter at the time of sugarcane ensiling reduces gas losses and improves nutritional composition of the silage.
Comparative and correlation analysis of experimental work for development of university teacher's knowledge management skills
Authors: Kalmykova Diana A.
Published: February 2020

The paper considers the problem of the inconsistency of the traditional educational process of higher education with changes in the socio-economic environment at the present stage of development of society. The conditions that are necessary today for training students with multidisciplinary thinking oblige the teacher to act as a consultant, coach, mentor and manager-organizer of the educational process, which has now become identical to the knowledge management process. Changing the role of the teaching staff of the educational organization of higher education actualizes the task of development of university teacher's knowledge management skills. The article presents the results of comparative and correlation analyzes of experimental work on development of university teacher’s knowledge management skills, considered as an integrative property of a person, combining value-motivational, instrumental-digital, scientific-research, evaluative-analytical, interactive-communication and academic and business components. The author proposed indicators of the selected components in the readiness structure, described their development and determined the dominant indicators of each component as a result of establishing and formative experiments. The materials of the experimental work presented in the article are aimed at identifying and enhancing both the relationships between the components of development and the relationships between the dominant indicators of structural elements. The results obtained indicate the development of all components in the readiness structure by means of additional professional educational programs. The analysis allows us to talk about the possibility of forming the components of the university teacher’s development for knowledge management due to the compensatory properties of indicators of the elements of its structure.
The impact of vocational training or retraining on professional activities of older people
Authors: Lapshova Ekaterina S. , Nikolaeva Svetlana V.
Published: February 2020

According to statistics, the number of people aged 60+ worldwide will double by 2050. In Russia, in connection with the change in federal legislation, the problem of the labor activity of older people is being updated. According to these data, governments of different countries are taking more and more measures to ensure the employment of older people. Lifelong learning provides an opportunity for older people to work especially in the workplace, where labor requirements and competencies are constantly changing. The purpose of this study is a theoretical analysis of the impact of vocational training and retraining on the work of older people. During the survey of respondents, three main types of barriers to participation in vocational training were identified: situational, institutional, and dispositional. During the investigation, a complex analysis was used, which includes the socio-demographic, socio-gerontological, statistical-economic, sociological, socio-psychological approaches, as well as sociological methods including the method of observation and conversation for obtaining, processing and interpreting information were used. The results indicate that vocational training and retraining of older people is an important factor in their participation in work. The low coverage of older people with vocational education and retraining programs can be overcome by popularizing vocational education as a tool for developing a career, preventing a career decline, and adapting older people to the labor market.
MARKERS OF INFLAMMATION IN THE BLOOD PLASMA OF PATIENTS WITH FRONTOTEMPORAL DEMENTIA
Authors: Androsova L V , Zozulya S A , Mikhailova N M , Fedorova Ya B , Klyushnik T P
Published: February 2020

The aim of this work was to identify several markers of inflammation in the blood of patients with frontotemporal dementia (FTD). 34 patients were surveyed with FTD. The control group consisted of 35 age- and sex- matched healthy people. Blood plasma was used for immunological studies. The enzymatic activity of leukocyte elastase (LE) and the functional activity of the α1-proteinase inhibitor (α1-PI) were determined by a spectrophotometric method, the concentration of interleukin-6 (IL-6) and C-reactive protein (CRP) were measured by ELISE. A statistically significant increase in α1-PI activity (p < 0.0001) was detected in patients with FTD; no difference from control was found for other indicators. There is a significant variation in all indicators, i.e. both increase and decrease of values compared to the control group. According to the level of LE activity, two immunophenotypes were identified. 73.5% of patients with FTD have an immunophenotype characteristic of patients with endogenous psychosis and 26.5% of patients have an immunophenotype similar to Alzheimer’s disease. The data obtained indicate the involvement of inflammatory reactions in the development of FTD and the heterogeneity of this disease as assed by immunological parameters.
DELAYED COGNITIVE DEFICIT AS A RESULT OF NEONATAL LIPOPOLYSACCHARIDE EXPOSURE: A PRESUMABLE IMPLICATION OF LONG-LASTING CHANGES OF NEUROPLASTIC GENE EXPRESSION
Authors: Trofimov A N , Zubareva O E , Schwarz A P , Veniaminova E A , Fomalont K , Klimenko V M
Published: February 2020

Disorders of the CNS development at an early age caused by various types of perinatal pathology, such as infectious diseases, trauma, hypoxia and ischemia, often lead to the development of cognitive brain dysfunctions in adulthood. Proinflammatory cytokines play key role in these pathological processes and can affect the expression of genes involved in the regulation of neuroplasticity. This article describes the changes in the expression of fibroblast growth factor-2 (Fgf2), as well as genes encoding matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), proteins that by intercellular matrix re-modeling are involved in the regulation of neuroplasticity.
STATE OF CYTOKINES, ALPHA-AMYLASE AS A MARKERS OF AUTONOMOUS NERVOUS SYSTEM AND CORRECTION WATER DRINKING BEHAVIOR
Authors: Baisheva G M , Melnik K N
Published: February 2020

The aim. Detect the relationship between sympathetic activity, secretory alpha-amylase (sAA) indices and mediators of the immune system in healthy young volunteers (18-20 years) with correction drinking behavior (use pure water of 35 ml/(kg body weight)). Materials and methods. A randomized, placebo-controlled double-blind study, which was carried out in 3 stages (09/20/2014; 08/11/2014; 12/13/2014) into 3 groups (test, placebo and control). The material used was saliva, in which IL-1β, IL-4, IL-6 were detected by ELISA and the activity of alpha-amylase (sAA) was determined colorimetrically on an automatic analyzer; the level of sympathicotonia was determined by calculating the Kerdo-index. Results. A decrease in the activity of sAA test and placebo groups to the second stage, and the preservation of this trend in these groups by the end of the study, in contrast to the increase in its activity in the control group. The ratio of IL-1β/IL-6 at the third stage (MCC, p = 0.048) in the test and placebo groups (146.66 and 111.61, respectively) exceeded (by 3 times and 2.4 times respectively) this indicator control group. In a subpopulation with a predictor of inflammatory diseases (PID) of the oral cavity (IL-1β ≥ 212 pg/ml) of the experimental group, the average IL-1β decreased to the third stage by 27% (from 247.7 pg/ml to 194.4 pg/ml), in the placebo group, a similar decrease was 31.5% (from 243.24 pg/ml to 184.96 pg/ml), while in the control the level of IL-1β remained at the same level (about 250 pg/ml), p > 0.05. By the end of the research, the Kerdo index showed a predominance in the test group of participants with parasympathicotonia (66.67%), while in the placebo group this figure was 58.33%, and in the control 50%. Conclusion. The obtained data suggest an immunomodulatory effect of the use of 35 ml/(kg body weight) of pure water (clean by the physical method) against a decrease in sympathicotonia.
THE AUTONOMIC NERVOUS SYSTEM IN THE CORRECTION OF FUNCTIONAL DISORDERS OF THE SMALL INTESTINE IN THE COMPLEX TREATMENT OF EXPERIMENTAL ETHANOL INTOXICATION
Authors: Sluchanko E I
Published: February 2020

The work is devoted to fundamental medical and biological studies, which make it possible to understand the basic laws of photobiology, part of which is super venous laser irradiation of blood. Neurohistochemical, histochemical, and electrophysiological methods were studied in the Wistar rats morphofunctional state of the small intestine under the influence of the supravenous laser blood irradiation in the complex treatment of experimental ethanol intoxication.The importance of the autonomic nervous system in the understanding of the characteristics of the effect of superluminal laser irradiation of blood on biological tissues in the complex treatment of experimental ethanol intoxication is emphasized. Experimental pathogenetically justified use of laser stimulation initiates the activation of adaptive processes, which is reflected in the restoration of the motor function of the small intestine on the 3rd day after the treatment of ethanol intoxication. The changes observed by us under the influence of supravenous laser irradiation of blood can be estimated as a state of increased activation of autonomous regulatory systems of the small intestine. Normalization after the use of supravenous laser irradiation of blood imbalance of neuromediation in the tissues of the small intestine, the increased activity of the enzymes of the aerobic cycle in the muscular layer of the named intestine is a consequence of adaptive changes, which is reflected in the restoration of the motor function of the small intestine with ethanol intoxication.
DESIGN OF COMPOUNDS WITH ANTICONVULSANT ACTIVITY AMONG NMDA-RECEPTOR LIGANDS
Authors: Brusina M A , Kubarskaya L G , Iljin V V , Nikolaev D N , Piotrovskiy L B
Published: February 2020

NMDA receptors play an important role in the development of immune responses. Therefore, the design of NMDAergic compounds presents great interest in various areas, including immunology. We have previously shown that some imidazole-4,5-dicarboxylic acid (IDA) derivatives are ligands of these receptors, and can exhibit both agonistic and antagonistic activities. In continuation of these studies and in attempt to establish the main structural parameters that determine the type of the activity, we developed a general method for synthesis of 1-, 2-mono and 1,2-disubstituted IDA derivatives. To establish the structure-activity relationship in the series under investigation, which include about 30 compounds, we try to find correlations of biological activity with the structure of compounds and some their physicochemical parameters (for example, partition coefficients between the lipophilic and hydrophilic phases). Pharmacological analysis in vivo of this set in various models under ip administration showed that a part of them induces a pre-convulsive state in mice of the CBA line, while the other part has a pronounced anticonvulsant effect on the NMDA-induced seizures. Thus, in the series of compounds under investigation substances that are both convulsants and anticonvulsants were found. The results of this study will allow us to design new drugs with anticonvulsant action.
The effect of orexin A application on the reaction of microglia cells body size stimulated by LPS injection
Authors: Synchikova A P , Horiuchi H , Nabekura J
Published: February 2020

The purpose of this study is to determine the effect of orexin A to LPS-activated microglia by investigating the morphological change. The effect of orexin on the level of LPS-activated microglia activation during the transition to the M1 phenotype was determined, which can be studied by measuring the cell area of the body.
THE GABA-ERGIC SYSTEM DOES NOT CONTROL THE NOCICEPTIVE RESPONSES OF PRIMARY SENSORY NEURON
Authors: Penniyaynen V A , Podzorova S A , Terekhin S G , Krylov B V , Plakhova V B
Published: February 2020

The aim of the study was to elucidate the molecular mechanisms of the interconnection of the GABA-ergic and nociceptive systems at the level of the peripheral division of the CNS. The data obtained indicate that GABA does not affect the activation gating device of the NaV1.8 channel of the primary sensory neuron responsible for coding pain signals.This agent in a wide range of concentrations also does not affect the growth of neurites of sensory neurons of embryonic nervous tissue. These results confirm our assumption, expressed earlier that the asynaptic membrane of the primary nociceptive neuron is not under the control of the GABA-ergic system.
THE ROLE OF SYMPATHIC AND PARASIMPATIC INNERVATION IN NEUROIMMULAR INTERACTIONS WITH EXTERNAL GUINETAL ENDOMETRIOSIS
Authors: Andreev A E , Drobintseva A O , Polyakova V O
Published: February 2020

Currently the study of the role of peripheral nervous system in control of inflammation in endometriosis and its involvement in the development of the chronic pain syndrome in this pathology is of relevance. The purpose of this work was to assess the reciprocal location of sympathetic and parasympathetic nerve fibers with external genital endometriosis at various stages of progression. The samples for the study were the endometrial biopsies of patients of reproductive age with external genital endometriosis of I-IV stage of the disease, with primary sterility (n = 20). The control group consisted of 3 patients (n = 5) who did not have any signs of endometriosis. Molecular markers were visualized using the immunohistochemical method. Antibodies to tyrosine hydroxylase (TH, 1:200, Abcam, USA) and PGP 9.5 (PGP 9.5, 1:1000, Abcam, USA) were used as primary antibodies. Alexa Fluor 488 (1:1000, Abcam, USA) and Alexa Fluor 647 (1:1000, Abcam) were used as secondary antibodies. The results were visualized with a confocal microscope (FluoView1000 (Olympus)). 3D shooting was used to assess the reciprocal location of the studied markers. As a result of this work, it was found that the expression of both of studied markers was detected in all samples. The obtained data can significantly increase the understanding of the functioning mechanisms of the neoneurogenesis processes in ectopic and eutopic tissue, thereby allowing an increase in the accuracy of the endometriosis diagnostic methods.
EXPERIMENTAL MODEL OF CFS: COGNITIVE, PHYSICAL AND METABOLIC CHARACTERISTICS OF PATHOLOGY DEVELOPMENT
Authors: Filatenkova T A , Shanin S N , Fomicheva E E , Korneva E A , Serebryanaya N B
Published: February 2020

In the present study, an analysis of cognitive, behavioral, and metabolic changes during the dynamics of the development of pathology was conducted under an experimental model of chronic fatigue syndrome (CFS). A decrease in physical and research activity of experimental animals indicated the development of fatigue and a depressed emotional state. An increase in the concentration of lactate was also showed, that may indicate a violation of the energy metabolism.
Congenital penile epidermal cyst: a rare location
Authors: Jebaraj Abishai , Patil Santosh , Kundargi Vinay S. , Patil Basavesh S.
Published: February 2020

A 22 years old male presented with a mass over the penis since birth, which was painless and gradually increasing in size. The mass was excised and it was found to be penile epidermal cyst. Epidermal cyst is one of the most common benign tumors occurring in the body, which commonly occurs either congenitally or following trauma or surgery, where the epidermal elements get trapped within closed space. But here this case had no trauma and surgeries in the past and the mass present since birth-a case of congenital penile epidermal cyst.
Dorsal onlay buccal mucosal graft or penile skin graft substitution urethroplasty in bulbar urethral stricture: compare the outcome and review
Authors: Khandelwal Atul K.
Published: February 2020

Background: Authors describe their experience with dorsal onlay urethroplasty using Buccal mucosal graft or penile skin graft through dorsal sagittal urethrotomy for bulbar urethral stricture.Methods: From 2014 to 2017, 29 male patients with bulbar urethral stricture have been treated by one stage dorsal onlay substitution urethroplasty using buccal mucosal graft and penile skin graft. Patients with balanitis xerotica obliterans, unhealthy penile skin, oral mucosa pathology or those who had undergone more than one urethral dilation/internal urethrotomy or urethroplasty were excluded from study. Results were analyzed at 6th and 12th month follow up with clinical history and uroflowmetry. Clinical outcome was considered a failure when any postoperative instrumentation was needed, including dilation or optical internal urethrotomy.Results: A total of 16 men age between 21 to 56 years for buccal mucosa graft (BMG) urethroplasty and 13 men age between 18 to 59 years underwent dorsal onlay substitution urethroplasty using BMG and penile skin graft (PSG). Mean stricture length was 4.2 cm (3.8-6) for BMG urethroplasty and 4.1 cm (3.2-5) for PSG urethroplasty. Mean length and width of graft were 4.2 cm and 2.6 cm respectively in BMG urethroplasty while 4.6 cm and 2.5 cm in PSAG urethroplasty. Average follow up months were 13.4 months with overall success rate 87.5% in BMG urethroplasty while average follow up months were 14.6 months with overall success rate 82.3% in PSG urethroplasty.Conclusions: On short term follow up substitution urethroplasty using both penile skin and buccal mucosa graft have comparable results.
Synergy and optimization of Local institutional to Repair Gambir (Uncaria gambir Roxb) Market in Indonesia
Authors: Wedy Nasrul  , Zulmardi  , Indrayani Tri Irfa
Published: February 2020

The relation between institutions and synergy between social capital produce social capital performance. Relationship and synergy between social capital between institutions will produce the best collective action. Collective action formed able to solve a problem in and between the institutions. Research aim of looking at the a lot of synergy of local institutions, the performance of social capital are quoted on the gambir. So on as well will be canvassed to see the act of collectively that is formed to address the issues the market gambir.This research methodology used a quantitative approach. The kind of research is descriptive. This study using a case study in the agricultural gambir. Research methodology this used a quantitative approach.The kind of research is descriptive. The research uses strategy case study. A case study of agricultural market gambir (Uncaria Gambir Roxb). Enrichment data used method of qualitative. Forms used as, observation, interview, group discussions  and documentation. Data analysis in depth uses the method inductive analysis and logical analysis. The analysis of the performance of social capital market gambir shows high social capital performance. High social capital performance on the gambir because the network high on bonding social capital and sinerji high on bridging social capital. High social capital performance produce collective action. Collective action happened transact on time and the same place between farmers and gambir gatherers in the market village. The transaction in time and place the same caused the price of more competitive because the competition among gambir gatherers. Social capital has also built the collective action for the repair of products and the sustainability of gambir farming.
Exploring Instructor Evaluation, Affective Learning and Teacher Credibility in International Classrooms
Authors: de Boer Peter , Bordoloi Prantik
Published: February 2020

In recent years the globalization trend in higher education has continued. This borderless educational world provides students opportunities to select and follow a study programme anywhere in the world. The resulting international classrooms create challenges and opportunities for international study programmes in preparing their diverse student populations for the demands posed by today’s fast-paced (business) environment. The teacher plays a pivotal role in accommodating the increasingly diverse student body and facilitating learning while being mindful of different learning styles, expectations and needs. Whereas initially the consequences of having an international classroom was taken for granted, higher education institutions have increasingly become aware that it involves more than offering the curriculum in English. In this study we explore the linkages between the student diversity, in terms of self-reported nationality, ethnicity and native language, affective learning and teacher credibility in the context of international classrooms. A key objective of this study was to check the reliability of the measurement items and scales for use in research pertaining to international classrooms. For this study, data was collected from 183 students following the International Business programme at an undergraduate level at one of the most international Universities of Applied Sciences in the Netherlands. The study sample had students from 35 different countries with the Dutch (42%) and German (19%) students constituting the largest group. The sample was divided into two groups: those with the same ethnicity, nationality and native language as the teacher (student-teacher congruence), and those who were different (student-teacher incongruence). The results of this research suggest that the measurement tools for teacher credibility and affective learning are valid, whereas the tool for nonverbal immediacy did not prove reliable. In addition, the theory-driven hypotheses were not supported as no significant difference was found between the scores of affective learning and teacher credibility between the two different groups of students.
Fluency Strategies For Beginning Readers
Authors: Acosta-Tello Enid
Published: February 2020

Fluency in reading is crucial for comprehension of the written word. Traditionally we concentrate on fluency once a child is a proficient reader. However, fluency is a skill that can be successfully addressed with beginning readers. This article presents practical strategies to help beginning readers become fluent readers. Of course, these strategies are effective with proficient readers, however, the earlier we begin to use them, the sooner children will internalize the concept of fluency and practice it. These strategies are also effective with second language learners.
A IMPORTÂNCIA DA PESQUISA CIENTÍFICA E SUA PUBLICIZAÇÃO
Authors: Henkes Jairo Afonso
Published: February 2020

A pesquisa científica e sua divulgação devem propiciar condições de desenvolvimetno sustentável  emelhoria na vida dos cidadãos e o equilíbrio ambiental.
ESTRUTURA DA PAISAGEM NA BACIA HIDROGRÁFICA DO RIO MAIOR
Authors: Sutil Thaise , Pereira Jori Ramos , Ladwig Nilzo Ivo , Back Álvaro José , Henkes Jairo Afonso
Published: February 2020

O artigo tem como objetivo analisar a evolução da estrutura da paisagem ressaltando o uso e a cobertura do solo na bacia hidrográfica do Rio Maior, por meio de ferramenta de sistema geográfico de informação (SIG), visando contribuir na minimização dos impactos ambientais e fornecer dados para a implementação de um plano de manejo. Foram interpretadas, analisadas e quantificadas as mudanças estruturais da paisagem usando como referência imagens fotogramétricas do ano de 1957, 1978, 1996 e 2016. Os resultados extraídos dos mapas temáticos destacaram que houve uma transformação na paisagem nestes 59 anos, que se evidencia no aumento da área da vegetação secundária e de reflorestamento em detrimento da diminuição da área de agricultura que perdeu 34,8% da área que ocupava no ano de 1957. Outro elemento que deve ser mencionado é que do total de área 2560,1ha da bacia hidrográfica 87,41% (2123 ha) já foram requeridas para mineração de areia, cascalho, argila, caulim, carvão mineral e quartzo. A base de dados estruturada e disponível em ambiente de SIG é importante na continuidade da análise das métricas da paisagem e como base de dados para o planejamento e a gestão dos recursos hídricos da bacia.