Combined Effect of Famine Exposure and Obesity Parameters on Hypertension in the Midaged and Older Adult: A Population‐Based Cross‐Sectional Study
Authors: Zhang Lin , Yang Liu , Wang Congzhi , Yuan Ting , Zhang Dongmei , Wei Huanhuan , Li Jing , Lei Yunxiao , Sun Lu , Li Xiaoping , Hua Ying , Che Hengying , Li Yuanzhen 
Published: September 2021

Objectives. Undernutrition early in life may increase the incidence of adverse effects on adult health. The relations between undernutrition and obesity parameters (body mass index (BMI) and WC (waist circle)) and hypertension were often contradictory. Our study is aimed at identifying the combined effects of famine exposure and obesity parameters on hypertension in middle‐aged and older Chinese. Design. A population‐based cross‐sectional study. Setting. Data were selected from the China Health and Retirement Longitudinal Study Wave2011 (CHARLS Wave2011). Participants. The sample included 12945 individuals aged 45 to 96. Main Outcome Measurements. The study analyzed data from 12945 middle‐aged and older Chinese selected from CHARLS Wave2011. Differences between baseline characteristics and famine exposure/BMI levels/WC levels were evaluated using the t‐, Chi‐square‐ (χ2‐), and F‐test. Then, the difference in the prevalence of hypertension between baseline characteristics was estimated by the t‐ and χ2‐test. Finally, multivariable‐adjusted logistic regression models were used to explore the associations of famine exposure and obesity parameters with odds of prevalence of hypertension. Results. Among the 12945 participants, 1548 (11.96%) participants had been exposed to the Chinese famine during the fetal group, whereas 5101 (39.41%) participants and 4362 (33.70%) participants had been exposed to the famine during childhood and adolescence/adult group, respectively. Regarding the participants with BMI levels, 3746 (28.94%) were overweight, and 1465 (11.32%) were obese, whereas 5345 (41.29%) of the participants with WC levels were obese, respectively. Furthermore, 1920 (31.17%) had hypertension in males and 2233 (32.91%) in females. In multivariable‐adjusted models, famine exposure and obesity parameters were related with prevalence of hypertension independently in total populations ((1) model threec, famine exposure with prevalence of hypertension: the fatal‐exposed vs. no‐exposed group (OR1.27; 95% CI 1.08, 1.49); childhood‐exposed vs. no‐exposed group (OR1.64; 95% CI 1.44, 1.87); the adolescence/adult‐exposed vs. no‐exposed group (OR3.06; 95% CI 2.68, 3.50); P for trend < 0.001; (2) model threee, famine exposure with prevalence of hypertension: the fatal‐exposed vs. no‐exposed group (OR1.25; 95% CI 1.06, 1.47); childhood‐exposed vs. no‐exposed group (OR1.52; 95% CI 1.34, 1.73); the adolescence/adult‐exposed vs. no‐exposed group (OR2.66; 95% CI 2.33, 3.03); P for trend < 0.001; (3) model threeg, BMI levels with prevalence of hypertension: overweight vs. normal (OR1.75; 95% CI 1.60, 1.91); obesity vs. normal (OR2.79; 95% CI 2.48, 3.15); P for trend < 0.001; (4) WC levels with prevalence of hypertension: overweight vs. normal (OR1.42; 95% CI 1.36, 1.48)). When stratified by sex, results in both males and females were mostly similar to those in the total population. In general, interaction analysis in the multivariable‐adjusted model, compared with the combination of normal BMI/WC levels and no‐exposed famine group, all groups trended towards higher odds of prevalence of hypertension (the greatest increase in odds, adolescence/adult‐exposed group with obesity in BMI levels: (OR8.13; 95% CI 6.18, 10.71); adolescence/adult‐exposed group with obesity in WC levels: (OR6.36; 95% CI 5.22, 7.75); P for interaction < 0.001). When stratified by sex, the results in both males and females were also similar to those in the total population. Conclusion. Our data support a strongly positive combined effect of famine exposure and obesity parameters on hypertension in middle‐aged and elderly Chinese.