bluuebunny/crossref_metadata_2025 huggingface dataset:
PENINGKATAN KESADARAN TANGGAP BENCANA SEJAK DINI MELALUI SOSIALISASI MITIGASI BENCANA DENGAN PERMAINAN EDUKATIF BERBASIS MONOPOLI DI SD NEGERI BORANGAN
Authors: Prakosha Donni , Pramudhita Salsa Dilla Deva , Nurhanifah Luthfi , Zahrany Fitria Safrina , Firdaus Inayah Salma , Rahmah Dzakiyyah Fa'izatur , Nareswara Febia , Saputra Riski Rama Arif , Ayusla Rieke Septyan , Widi Bagus Siwi Ismoyo , Romadhon Alviyan Dwiki
Published: October 2024

Indonesia merupakan negara dengan tingkat risiko bencana alam yang tinggi. Anak-anak merupakan salah satu korban yang paling rentan saat terjadi bencana. Program pengabdian masyarakat ini dilaksanakan di SD Negeri Borangan, Kabupaten Klaten, dengan tujuan untuk meningkatkan pengetahuan dan kesiapsiagaan siswa terhadap bencana alam. Program menggunakan pendekatan permainan edukatif berbasis monopoli yang dirancang untuk memperkenalkan konsep mitigasi bencana secara interaktif dan menyenangkan. Hasil kegiatan ini menunjukkan peningkatan pemahaman siswa tentang berbagai jenis bencana dan langkah-langkah mitigasi yang tepat.  Program ini diharapkan dapat menjadi model edukasi mitigasi bencana yang efektif dan menarik bagi sekolah-sekolah lain di daerah rawan bencana.
.
Pleomorphic adenoma in an adolescent, about a clinical case
Authors: Soto-Castillo Damian , Wong-Silva Jadier , Bory-Porras Lucien Gregoria , Ramírez-Gómez Mario
Published: October 2024

Introduction: salivary gland tumors in children represent a low percentage of pediatric head and neck tumors; most of them are diagnosed in association with the Parotid salivary gland and present a higher proportion of malignancy than in adults. Objective: to present a case with a diagnosis of Pleomorphic Adenoma: clinical symptoms, complementary examinations, treatment and evolution. Case presentation: female patient, 13 years old, from a rural background and white race, attended the Maxillofacial Surgery consultation, in good general condition, accompanied by her parents, due to an increase in volume of a hard consistency, not fixed to deep planes ( mobile), asymptomatic, of 7 months of evolution and 3 cm in length located in the left parotid region. Ultrasound of soft tissues and neck was indicated, as well as contrast-enhanced facial mass tomography, which showed a mass in relation to the left parotid gland that captured contrast.   In addition, complementary examinations and a fine needle aspiration biopsy (FNAB) were performed, resulting in a benign parotid gland tumor (Pleomorphic Adenoma). Superficial parotidectomy was performed with preservation of the facial nerve. The patient progressed satisfactorily and continues to be followed up by consultation. Conclusions: pleomorphic adenomas are discovered in practice as slowly growing asymptomatic masses; the size is variable and will always depend on the stage at which it is detected.
A Review of High School English Post-reading Writing Teaching Research (2012–2023)
Authors: Wan Lei , Ma Tiantian
Published: October 2024

This paper uses the bibliometric method to conduct a statistical analysis of the related literature on post-reading writing from the past decade (2012–2023) available in CNKI. It systematically introduces the development of post-reading writing, comprehensively reviews its development process in China, and divides it into three stages: proposal and development, application in college entrance examinations, and prospects and reflections. The research content covers various aspects such as the theoretical basis, teaching practice, and effectiveness evaluation of post-reading writing. By analyzing the quantity, distribution, and content of the literature, it reveals the research hotspots and development trends of post-reading writing at different stages, providing valuable references for theoretical research and practical application in English education.
Evaluating Thalassemia Awareness in Academic Environments: A Comparative Study among Medical and Non-medical Students
Authors: Zahid Aasia , Shahid Bismah , Awais Hina , Mannan Talha , Jamil Anam , Bashir Fareeha
Published: October 2024

Thalassemia is a very common hemoglobinopathy that is present worldwide. When one of alpha and beta chains is not present in hemoglobin or is present in lesser amounts it causes thalassemia. 9 million population of Pakistan are carriers of thalassemia. 5% of the world’s cases of thalassemia are from Pakistan. This study is designed to check thalassemia awareness among medical and non-medical students. This was a cross-sectional study. 112 students were taken to answer the questionnaire through a non-random sampling technique. Out of the total participants, 57% were female respondents and 43% were male. Similarly, medical students were 58% and non-medical students were 42%. Of these, 81% medical and 57.1% of non-medical students knew that thalassemia is a genetic disorder. 64.5% of medical and 47.8% of non-medical students thought that there was a cure for thalassemia. Medical and non-medical students of 92% and 63.6% respectively, knew that thalassemia is treated with red blood cell exchange. 54.8% medical and 25% non-medical students knew that thalassemia is not contagious. It is concluded that medical students have more awareness of thalassemia than non-medical students. Medical students have more knowledge about the treatment and contagiousness of this disorder.
Validación de un instrumento para la identificación del capital intelectual en empresas mexicanas
Authors: Hernández García Patricia , López Torres Gabriela Citlali , Ramírez Flores Elfego
Published: October 2024

En la actualidad hacer frente a la competencia y a los ambientes dinámicos con el fin de ganar acceso a nuevos mercados y tecnologías, ha llevado a algunas organizaciones a contar con personas que poseen diversos talentos y que emplean su pericia hacia el logro de las metas organizacionales. El problema identificado se refiere a la falta de identificación de todos los elementos intangibles que generan valor, desarrollarlos, almacenarlos y lograr que permanezcan en la organización. El capital intelectual no se presenta en los estados financieros. El objetivo de la presente investigación es validar un instrumento para identificar los activos intangibles en organizaciones manufactureras en San Luis Potosí para analizar su impacto en el desempeño de las organizaciones La metodología de este trabajo de investigación es cuantitativa, aplicada, transversal y no experimental. Es necesario contar con las herramientas que permitan identificar los activos intangibles en organizaciones manufactureras con un instrumento de medición validado, con un Alpha de Cronbach de 0.976, lo cual es considerado como un resultado excelente y con alto grado de confidencialidad, permitirá una mejor administración del capital intelectual y un mejor desempeño.
Análisis de la relación del capital intelectual sobre el desempeño organizacional a través de la innovación de producto. Revisión de la literatura
Authors: Villasana Arreguin Laura
Published: October 2024

Desde que se acuñó el término capital intelectual ha sido visto como el conocimiento que las organizaciones poseen y que se usa para crear valor. Una de las principales interrogantes del capital intelectual se concentra en la cuestión de cómo puede utilizarse para favorecer la innovación de producto y mejorar el desempeño organizacional. El objetivo de esta investigación es hacer una revisión de la literatura para examinar la relación entre capital intelectual, innovación de producto y desempeño organizacional. Para hacer el análisis de los artículos científicos se utilizó la metodología propuesta por Levy y Ellis (2006). Como conclusiones se presentan los hallazgos recientes de la relación que existe entre dichos conceptos.
Experiencia en investigación: los avatares de mi camino hacia la generación, producción y difusión del conocimiento.
Authors: Valentin Mballa Louis
Published: October 2024

-
Preferencia por redes sociales e impacto de la publicidad digital de la oferta educativa de los estudiantes de nuevo ingreso al nivel superior
Authors: Urbiola Rodríguez Rosa Isela , Grimaldo Reyes Sanjuana Edith , Gómez Sánchez David
Published: October 2024

El presente trabajo de investigación muestra los resultados preliminares del trabajo denominado preferencia por redes sociales e impacto de la publicidad digital de la oferta educativa en los estudiantes de nuevo ingreso al nivel superior. La investigación es de diseño transversal, de enfoque cuantitativo, descriptivo y correlacional, la población está compuesta por 308 alumnas y alumnos de nuevo ingreso de la Unidad Académica Multidisciplinaria Zona Media (UAMZM) dependencia de la Universidad Autónoma de San Luis Potosí (UASLP). Se puede concluir que la mayoría de los encuestados manifestaron haber consultado información en las redes sociales de la UAMZM sobre la oferta educativa y el 43.8 % de los encuestados indicó que la publicidad en redes sociales incidió en su decisión al momento de elegir carrera. Se detectó que el 92.5% de los encuestados tiene una cuenta en la red social Facebook, sin embargo, esta no es la favorita de los estudiantes, la red social de preferencia es Instagram, seguido de Tik Tok, en tercera posición esta Facebook, YouTube y finalmente Twitter. Respecto a Instagram, el NSE A/B es el que más prefiere esta red, el NSE C+ manifiesta preferir Tik Tok, el NSE que más prefiere Facebook es también el A/B, también se concluye que no existe relación entre el NSE y la red social favorita de los estudiantes.
Sostenibilidad material
Authors: De la Rosa Leal María Eugenia
Published: October 2024

-
Understanding Hypothyroidism: Causes, Symptoms, Diagnosis, and Treatment Options for Optimal Thyroid Health
Authors: Bhandari Prabha , Manandhar Lumanti , Kandel Dipendra
Published: October 2024

Hypothyroidism is a condition where your thyroid gland doesn’t produce enough thyroid hormone leading to symptoms like fatigue, weight gain, and feeling cold.
Globally, the lack of iodine in the environment is the leading cause of hypothyroidism. However, in regions where there is enough iodine, Hashimoto’s thyroiditis, an autoimmune disorder is the most common cause.
Risk factors include having a family history of thyroid disease, being over 6o years and being female.
Diagnosis done with a simple blood test that measures the levels of serum free thyroxine (FT4) and thyroid-stimulating hormone (TSH). High TSH and FT4 levels usually indicate Hypothyroidism.
Even daily medication with synthetic thyroid hormone (levothyroxine), regular follow up with your doctor is important to monitor your TSH level and adjust the dosage of medication as needed.
XALQARO TURIZM DISKURSIGA OID TERMINLAR TARJIMASI MUAMMOSI
Authors: Buzrukova Maxina
Published: October 2024

This article analyzes the challenges encountered in translating terms related to international tourism discourse. International tourism discourse is a unique communication field that includes specialized terminological nominations. The research focuses on studying the issues of translating tourism terms between different cultures, synonymy and polysemy, and the cultural and linguistic features of translation. The article highlights the difficulties in the translation process, such as finding functional equivalents, calquing, and borrowing terms.
Exploration of the Practice and Effectiveness of Teaching Geography Using Statistical Geographic Information Service(SGIS)
Authors: Lee Jeong-Min , Kim Young-Hoon
Published: October 2024

This research paper investigates the use of the Statistical Geographic Information Service (SGIS) within the context of a digital geospatial platform in high school geography classes in Korea. The platform supports creative thinking and competency development in the 2015 revised national curriculum. The study proposes SGIS-integrated teaching modules and evaluates their effectiveness in enhancing geography education. Our findings indicate that SGIS serves as a valuable pedagogical tool, promoting student-centered learning and motivation while improving geographical knowledge. The research highlights SGIS's interdisciplinary relevance in visualising geospatial data and its broad applicability in geography instruction. Additionally, it suggests further research on SGIS's role in enhancing teacher competencies and its alignment with the 2022 revised curriculum's emphasis on digital literacy and critical thinking. Overall, the paper concludes that the integration of SGIS into geography classes has been successful and indicates a promising future for incorporating digital tools in social scientific education.
HERNIORRAFIA PERINEAL BILATERAL ASSOCIADA A RESSECÇÃO RETAL E COLOPEXIA PARA CORREÇÃO DE DILATAÇÃO RETAL: RELATO DE CASO
Authors:   Lucas Rosestolato, Machado Julia Zuanazzi
Published: October 2024

A hérnia perineal é uma condição grave que ocorre principalmente em cães machos não castrados e costuma afetar animais com cerca de 10 anos de idade. A patologia é caracterizada pelo enfraquecimento dos músculos perineais, resultando na deslocação de órgãos pélvicos e abdominais, o que compromete a defecação e, em casos mais graves, leva à incontinência urinária e/ou fecal. O diagnóstico é realizado com base no histórico clínico, exame físico e, se necessário, exames complementares como radiografia e ultrassonografia, que ajudam a determinar o envolvimento de órgãos como a bexiga e o intestino. Embora o tratamento clínico possa aliviar os sintomas, o tratamento definitivo é cirúrgico. O caso relatado descreve o caso de um cão com hérnia perineal bilateral e dilatação retal, com duas intervenções cirúrgicas, a primeira envolveu a reparação das hérnias com técnicas diferentes em cada lado, sendo lado direito a transposição do musculo semitendinoso contralateral e lado esquerdo técnica padrão. E a segunda intervenção incluiu a colopexia, resseção e anastomose do reto dilatado, onde o paciente teve uma recuperação satisfatória com regressão dos sinais clínicos anteriormente apresentados e restauração da qualidade de vida.
Utilization of underutilized green leafy vegetables in the development of value added products
Authors: Yadav Sushmita , Singh Pallavi
Published: October 2024

This research assesses the nutritional content and proximate composition of three underutilized dried green leafy vegetables: cauliflower, beet, and carrot leaves. Edible products like laddu, shakkarpara, and nutribars were made using dried leaf powder. Results indicated that cauliflower leaves have the greatest protein content (21.87 g/100g), followed by carrot leaves (17.06 g/100g). Sensory analysis revealed that 5% dried cauliflower leaf powder performed the best in terms of sensory attributes. The study highlights the potential of these underutilized vegetables in enhancing nutritional value.
Management of Wilson’s disease in a 5 year old patient
Authors: Sharma Pooja
Published: October 2024

Wilson's disease is a rare inherited disorder characterized by excess copper accumulation in the liver, brain, and other vital organs. This case report describes a 5-year-old patient diagnosed with Wilson’s disease after exhibiting symptoms like jaundice, shortness of breath, and ascites. The patient was treated with a low-copper diet and medication, which led to significant improvements. The case underscores the importance of early diagnosis and nutritional management in managing Wilson's disease
Analisis Rasio Keuangan Tehadap Pemberian Opini Audit Going Concern Oleh Auditor Independen Pada Perusahaan Perbankan Yang Terdaftar Di Bursa Efek Indonesia (BEI) Tahun 2009-2011
Authors: Suryantoro Bambang , Mulyono Mulyono , Kusnanto Eri
Published: October 2024

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis sejauh mana pengaruh rasio keuangan terhadap pemberian laporan audit going concern oleh auditor independen pada perusahaan perbankan yang terdaftar di Bursa Efek Indonesia. Sampel yang diambil adalah 26 perusahaan perbankan yang terdaftar di Bursa Efek Indonesia selama periode 2009-2011 yang telah diseleksi dengan metode purposive sampling. Variabel-variabel independen yang digunakan dalam penelitian ini adalah Rasio Likuiditas yang diukur dengan Quick Ratio, Rasio Profitabilitas yang diukur dengan Return on Asset, Rasio Solvabilitas yang diukur menggunakan Capital Rasio, Rasio efisiensi usaha yang diukur dengan Cost of Fund dan Rasio Resiko Usaha yang diukur dengan Credit Risk. Dalam penelitian ini penulis menggunakan metode deskriptif dengan uji analisis regresi logistik yang didahului dengan pengujian goodness of fit dan pengujian asumsi klasik yang terdiri dari uji multikonlinieritas dan uji autokorelasi. Hasil penelitian menunjukkan bahwa hanya variabel Profitabilitas yang berpengaruh signifikan terhadap pemberian laporan opini audit going concern, sedangkan empat variabel lainnya yaitu Likuiditas, Solvabilitas, Efisiensi Usaha dan Resiko Usaha tidak berpengaruh signifikan terhadap pemberian laporan opini audit going concern.
Analisis Pengaruh Elemen Neraca Sisi Kredit Berupa Hutang Jangka Panjang Dan Modal Terhadap Pajak Penghasilan (PPh) Badan Terutang (Studi Empiris Pada Perusahaan Makanan Dan Minuman Yang Terdaftar Di Bursa Efek Indonesia Tahun 2005-2008)
Authors: Ruslaini Ruslaini , Praningsih Tati
Published: October 2024

Laporan keuangan merupakan instrumen yang sangat penting bagi para pemegang kepentingan. Aspek permodalan merupakan hal yang sangat penting dalam suatu perusahaan. Hal ini disebabkan oleh besarnya modal yang dimiliki oleh perusahaan baik dalam bentuk modal sendiri maupun hutang, dapat mencerminkan keadaan yang sesungguhnya tentang kondisi pengelolaan suatu perusahaan. Modal dan hutang jangka panjang merupakan elemen laporan keuangan yaitu laporan neraca. Penggunaan kedua aspek ini secara optimal diharapkan akan dapat mengoptimalkan nilai pajak penghasilan terutang perusahaan.
Penelitian ini bertujuan untuk menganalisis pengaruh dari kedua elemen neraca tersebut terhadap pajak penghasilan terutang pada perusahaan industri makanan dan minuman khususnya yang terdaftar di Bursa Efek Indonesia pada tahun 2005 sampai dengan tahun 2008.
Hasil penelitian menunjukkan bahwa baik secara simultan (bersama-sama) maupun parsial (sendiri) aspek hutang jangka panjang dan modal berpengaruh secara signifikan terhadap pajak penghasilan terutang badan.
Berdasarkan pengujian simultan hutang jangka panjang dan modal berpengaruh terhadap pajak penghasilan terutang dengan koefisien determinasi sebesar 62,6 % dan sisanya sebesar 37, 4% dipengaruhi oleh faktor-faktor lain.
Berdasarkan pengujian secara parsial masing-masing variabel tersebut mempunyai hubungan linear dengan pajak penghasilan terutang dengan nilai T pada uji T sebesar 2, 433 untuk hutang jangka panjang dan 2, 354 untuk modal.
Kepemimpinan dan Motivasi Terhadap Kinerja Pegawai
Authors: Kencana Kartika Cahya
Published: October 2024

Di dalam suatu organisasi figur seorang pemimpin sangat dibutuhkan untuk mencapai kinerja atau prestasi kerja pegawai yang maksimal, penggunaan kepemimpinan yang tepat dari atasan, merupakan salah satu faktor yang dapat menggerakkan, mengarahkan, membimbing dan memotivasi pegawai untuk lebih berprestasi dalam bekerja. Kepemimpinan atau leadership merupakan ilmu terapan dari ilmu-ilmu sosial, sebab prinsipprinsip dan rumusannya diharapkan dapat mendatangkan manfaat bagi kesejahteraan manusia. kepemimpinan merupakan kemampuan mempengaruhi orang lain, bawahan atau kelompok, kemampuan mengarahkan tingkah laku bawahan atau kelompok, memiliki kemampuan atau keahlian khusus dalam bidang yang diinginkan oleh kelompoknya, untuk mencapai tujuan organisasi atau kelompok. Tipe kepemimpinan di Indonesia sangat beragam seperti, otokratik, raternalistik, kharismatik, demokratik, motivasi, kinerja. Penelitian kali ini berkaitan dengan motivasi terhadap kinerja karyawan, untuk memperoleh hasil yang maksimal dalam perusahaan sangat diperlukan motivasi karena motivasi merupakan suatu kondisi yang mendorong atau menjadikan sebab seseorang melakukan suatu perbuatan/kegiatan, yang berlangsung secara sadar. Pentingnya motivasi karena motivasi adalah hal yang menyebabkan, menyalurkan dan mendukung perilaku manusia, supaya mau bekerja giat dan antusias mencapai hasil yang optimal serta meningkatkan kualitas sumber daya manusianya itu sendiri.
Analisis Kepatuhan Pelaporan Pajak Pertambahan Nilai Terhadap Perubahan UU PPN No 18 Tahun 2000 Ke UU PPN No 42 Tahun 2009 Pada Pt. Jaring Semesta Infosolusi Tahun 2009-2011
Authors: Ruslaini Ruslaini , Ardana Pitharia
Published: October 2024

Dalam menjalankan kegiatan usaha, setiap perusahaan tentunya berkaitan denganperaturan-peraturan yang ada. Salah satunya adalah peraturan pajak, yang dimana setiapperaturan mempunyai kebijakan sendiri-sendiri. Oleh karena itu, setiap perusahaan harus mempunyai skema pembayaran dan pelaporan pajak yang tepat waktu agar salah satu tujuan perusahaan dapat tercapai. Penelitian ini menggunakan metode pendekatan kualitatif, dan aspek yang diuraikan meliputi analisis pelaporan pajak pada tahun 2009 dan 2010 terhadap penyesuaian undang-undang yang ada. Metode pengumpulan data melalui penelitian kepustakaan, penelitian lapangan, dan dokumentasi. Penelitian lapangan dilakukan dengan pengamatan dan wawancara seperti yang telah penulis lakukan dalam kegiatan langsung bekerja sebagai karyawan di perusahaan tersebut. Pelaporan pajak dimaksudkan untuk mengetahui bahwa pelaporan pajak yang dilaksanakan telah sesuai dengan undang-undang yang berlaku. Berdasarkan hasil penelitian, pelaporan pajak yang dilakukan oleh PT. Jaring Semesta Infosolusi pada tahun 2009 dan 2010 sudah sesuai dengan undang-undang yang berlaku, sedangkan pelaporan pajak untuk tahun berikutnya, hanya tinggal mengikuti pada pelaporan pajak pada tahun 2010, karena belum adanya penyesuaian kembali terhadap undang-undang perpajakan terutama terhadap pajak pertambahan nilai. Untuk pelaporan pajak pertambahan nilai yang akan dilakukan oleh PT. Jaring Semesta Infosolusi pada tahun berikutnya, harus memperhatikan setiap peraturan yang berlaku agar terhindar dari sanksi administrasi perpajakan, sehingga pelaporan pajak pertambahan nilai yang dilakukan sesuai peraturan yang berlaku beserta perubahannya dan terlaksana dengan benar.
Working with Difficult Colleagues: Strategies for Managing Conflict and Maintaining Productivity
Authors: Westover Jonathan
Published: October 2024

This article explores research-backed strategies for effectively managing workplace conflicts and collaborating productively even with difficult or disliked coworkers. While interpersonal disputes are inevitable in team environments where personalities and work styles differ, the research shows proper handling of conflicts can spark innovation, while improper addressing can breed toxicity. The article presents a framework for constructively channeling conflicts through establishing clear boundaries, addressing disagreements calmly and respectfully, avoiding personal criticisms, discreetly addressing issues to shield others, and upholding civility and professionalism at all times. Real-world examples from hospital administrators, project managers, and nonprofit CEOs illustrate applying these strategies in navigating philosophical divides and personality clashes. The conclusion is that with strategic relationship management focused on issue-solving over blaming, and principles-based leadership, leaders can work productively despite challenges from certain colleagues.
Efektivitas Pelatihan Pembuatan E-LKPD Menggunakan Wizer.me, OLabs dan Proprofs Quiz Maker untuk Guru di SMAS Ittihadul Ummat
Authors: Susanti Ernita , Sulistyaningsih Dwi , Sofi Makiyah Yanti , Muhammad Ridwan Irwan , Nana
Published: October 2024

The use of technology in learning is essential in the context of today's digital education. By utilizing technology, teachers can improve the quality of learning. Therefore, training in making E-LKPD (Electronic Student Worksheets) using Wizer.me, assisted by OLabs and Proprofs Quiz Maker, is essential to help teachers at SMAS Ittihadul Ummat adapt to digital education trends. The main objective of this training is to improve the quality of learning by introducing relevant and innovative technology to teachers. The training method will involve a series of interactive sessions led by the community service team, consisting of lecturers and students. The training uses a practical approach method by demonstrating the use of the Wizer.me, OLabs, and Proprofs Quiz Maker platforms in making exciting and useful E-LKPD. Participants practice the skills learned directly and get direct guidance from the community service team. The targeted outputs of this program are publications in ISSN community service journals, publications in mass media, HAKI, activity videos and training modules. This activity improves teachers' understanding and skills in utilizing technology for learning, especially in creating interactive E-LKPD. Additionally, increase teacher motivation and interest in learning to continue to develop themselves in using technology in the learning process at SMAS Ittihadul Ummat.
HUBUNGAN TINGKAT PENGETAHUAN IBU TERHADAP KEJADIAN ISPA PADA BALITA
Authors: Lestari Sri , Barkah Asep
Published: October 2024

Latar Belakang : ISPA merupakan penyebab utama tingkat kesakitan dan kematian akibat penyakit menular di dunia. Insiden  ISPA di negara Afrika dan Asia diperkirakan terjadi kematian pada golongan usia balita sekitar 15%-20% pertahun. Sebanyak 49% kematian pada anak usia dibawah 5 tahun di Afrika dan 24% terjadi di Asia Tenggara. Di Indonesia penyakit ISPA merupakan penyakit tertinggi pertama penyebab kematian pada bayi dan angka kesakitan pada balita sebesar 20,06%. Pada tahun 2021, di Kabupaten Bekasi cakupan penemuan ISPA pada balita sebesar (8,89)% dengan jumlah kasus yang ditemukan sebanyak 1.093 kasus. Salah satu faktor yang mempengaruhi kejadian ISPA pada balita adalah pengetahuan. Tujuan : Mengetahui hubungan tingkat pengetahuan ibu terhadap kejadian ISPA pada Balita. Metode : Analitik dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah seluruh ibu yang memiliki Balita yang berobat di Puskesmas Telaga Murni pada tanggal 01 – 30 November 2022 pada saat penyebaran kuesioner sebanyak 85 orang. Teknik pengambilan sampel menggunakan accidental sampling. Hasil : Sebagian besar balita mengalami ISPA 72,9% dan ibu berpengetahuan baik 62,4%. Adanya hubungan antara pengetahuan dengan kejadian ISPA pada balita, hasil uji statistic Chi-Square diperoleh nilai p.value.0,003. Kesimpulan : Adanya hubungan antara pengetahuan dengan kejadian ISPA pada balita, hasil uji statistic Chi-Square diperoleh nilai p.value.0,003. Tenaga kesehatan diharapkan lebih aktif lagi dalam memberikan edukasi tentang ISPA kepada masyarakat supaya kejadian ISPA pada balita berkurang.
EFFEKTIVITAS AEROBIC EXERCISE DAN STRETCHING EXERCISE INTRADIALYTIC TERHADAP PENURUNAN RESTLESS LEG SYNDROME PADA PASIEN GAGAL GINJAL KRONIK DENGAN HEMODIALISIS
Authors: Fauzi Achmad , Ahmedy Fatimah , Rosidah Rosidah
Published: October 2024

Latar Belakang : Gagal ginjal kronis, juga dikenal sebagai disfungsi kronis ginjal progresif dan ireversibel, adalah proses yang menyebabkan uremia dan membantu mengontrol metabolisme, keseimbangan kalori, dan keseimbangan elektrolit. Ini menimbulkan bahaya bagi sejumlah penyakit, termasuk obesitas, diabetes, hipertensi, dan kanker ginjal. Tujuan : mengevaluasi efektivitas masih perlu dikonfirmasi effektivitas aerobic exercise dan stretching exercise intradialytic terhadap penurunan restless leg syndrome pada pasien gagal ginjal kronik dengan hemodialisis. Metode : Penelitian ini menggunakan pendekatan kuasi eksperimen kuantitatif yang dibagi kedalam kelompok intervensi dan kontrol, pada Rumah Sakit Haji Jakarta selama 4 minggu. Empat puluh peserta terdaftar di setiap kelompok, sehingga total 80 peserta terdaftar. Purposive sampling digunakan untuk memilih responden. Selain itu, setiap responden diminta melengkapi skala penilaian International Restless Legs Syndrome Study Group (IRSSG). Hasil : Mayoritas responden laki-laki sebanyak 42 responden (52,50 %), Lamanya hemodialysis >12 bulan (85%), dan memiliki tingkat hemoglobin kurang dari 10 mg/dl (80%). Hasil penelitian ini menunjukkan bahwa: Pada kelompok intervensi Aerobic Exercise dan Stretching Exercise Intradialytic mengalami penurunan tingkat RLS dengan skor rata-rata pre test 2.12 menjadi 1.56 saat post test dengan nilai p value (0,001<0,05), sedangkan pada kelompok kontrol tidak terjadi, dimana nilai rata-rata pre test 2.06 menjadi 2.19 saat post test dengan p value (0,164>0,05). Kesimpulan : Terdapat pengaruh Aerobic Exercise dan Stretching Exercise dengan media audio visual terhadap tingkat RLS pada pasien gagal ginjal kronik yang menjalani hemodialisis. Studi berikutnya dapat mempelajari faktor-faktor yang mempengaruhi keberhasilan Aerobic Exercise dan Stretching Exercise dalam menurunkan RLS.
Investigating the Role of Visual Storytelling in Enhancing Audience Engagement in Digital Journalism
Authors: Huang Xin , Li Xiang , Yao Jianlin
Published: October 2024

The rise of digital media has fundamentally changed the way news is consumed, making audience engagement a critical success factor for news outlets. But in an age of information overload, traditional story-based journalism often struggles to capture and hold readers’ attention. This study examines the role of visual storytelling in increasing audience engagement with digital media, addressing the problem of readers not interacting with online content. The ultimate goal is to examine how various visual media—such as infographics, video, and interactive graphics—influence audience attention, retention, and engagement. Using a mixed methods approach, including case studies, audience research, and engagement metrics, the study found that infographics and data visualization provided when telling a visual story in articles, social media engagement, and user engagement increased significantly Time on page was shown to increase by up to 50%, while emotional visual evocative stimuli such as images and video increased audience engagement by 70% The findings highlight the potential of visual storytelling to transform digital media through engaging, memorable and interactive content. The study recommended that news organizations invest in visual storytelling to ensure ethical reporting and accessibility, and position themselves for future innovations such as AI, AR and VR.
Tricky Terms In Legal Translation from and to English: Stepping up to the Classroom Challenge
Authors: Klabal Ondřej
Published: October 2024

Legal translation competence includes a high number of sub-competences that legal translation trainees need to master. Therefore, trainers may have no time to tackle issues at the very micro level that are challenging not only for legal translation trainees, but sometimes even for professional translators. Although many such issues are identified in legal translation textbooks, the prevailing holistic approach to teaching legal translation may have led to such issues being sidelined in the legal translation classroom. Drawing on the author’s experience as a legal translation trainer, this paper attempts to fill this vacuum and offer a systematic approach to addressing at least some of these phenomena. A selection of tricky terms will be presented, together with practical activities designed to raise trainees’ awareness of such issues and teach them how to approach them confidently when translating from and to English. Four groups of terms are covered: false friends in general and legal language; vague terms such as good and reasonable; non-transparent terms where complex legal meaning is packed into a simple term (constructive, in lieu of), and enantiosemous terms (apparent, qualified). It is believed that when such phenomena are tackled in isolation, trainees may become better equipped to deal with them successfully the next time they encounter them in an English source text or to use them actively when translating into English.
Numerical analysis approach to twin primes conjecture
Authors: Di Pietro Gabriele
Published: October 2024

This paper provides a better approximation of the functions presented in the article “Numerical Analysis Approach to Twin Primes Conjecture” (see [3]). The new estimates highlight the approximations used in the previous article and the validity of Theorems 1 and 2 through the use of the false hypothesis based on the distribution of primes punctually following the Logarithmic Integral Li(x) (see [4] and [7], pp. 174–176) will be re-evaluated.
Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos
Authors: Hou Yanlin , Nie Zhengwen , Jiang Qi , Velychko Sergiy , Heising Sandra , Bedzhov Ivan , Wu Guangming , Adachi Kenjiro , Schöler Hans R
Published: October 2024

During the first lineage segregation, mammalian embryos generate the inner cell mass (ICM) and trophectoderm (TE). ICM gives rise to the epiblast (EPI) that forms all cell types of the body, an ability referred to as pluripotency. The molecular mechanisms that induce pluripotency in embryos remain incompletely elucidated. Using knockout (KO) mouse models in conjunction with low-input ATAC-seq and RNA-seq, we found that Oct4 and Sox2 gradually come into play in the early ICM, coinciding with the initiation of Sox2 expression. Oct4 and Sox2 directly activate the pluripotency-related genes through the corresponding OCT-SOX enhancers in the early ICM. Furthermore, we observed a substantial reorganization of chromatin landscape and transcriptome from the morula to the early ICM stages, which was partially driven by Oct4 and Sox2, highlighting their pivotal role in promoting the developmental trajectory towards the ICM. Our study provides new insights into the establishment of the pluripotency network in mouse preimplantation embryos.
Avian-restrict Salmonella transition to endemicity is accompanied by localized resistome adaptation
Authors: Jia Chenghao , Huang Chenghu , Zhou Haiyang , Zhou Xiao , Wang Zining , Siddique Abubakar , Kang Xiamei , Cao Qianzhe , Huang Yingying , He Fang , Li Yan , Yue Min
Published: October 2024

Bacterial regional demonstration after global dissemination is an essential pathway for selecting distinct finesses. However, the stepwise evolution of the resistome during the transition to endemicity remains unaddressed. Using the most comprehensive whole-genome sequencing dataset of
Salmonella
enterica serovar Gallinarum (
S
. Gallinarum) collected from 16 countries over the past century, we first elucidated the pathogen’s population structure. Subsequently, we revealed the international transmission and evolutionary history of
S
. Gallinarum to recent endemicity through phylogenetic analysis conducted within a spatiotemporal Bayesian framework. Our findings indicate that the independent acquisition of the resistome via the mobilome, primarily through plasmids, transposons, and prophages, shapes a unique antimicrobial resistance profile. By utilizing the pipeline we developed to investigate the frequency of horizontal resistome transfer, we identified a significantly higher rate of cross-region dissemination compared to localized propagation, highlighting the key role of the resistome in driving the transition and evolutionary history of
S
. Gallinarum. Collectively, this study elucidates resistome adaptation in the endemic transition of a single pathogen, providing valuable insights for targeted policy interventions.
The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction
Authors: Winder Lucy A , Simons Mirre JP , Burke Terry
Published: October 2024

Life-history theory, central to our understanding of diversity in morphology, behaviour and senescence, describes how traits evolve through the optimisation of trade-offs in investment. Despite considerable study, there is only minimal support for trade-offs within species between the two traits most closely linked to fitness – reproductive effort and survival – questioning the theory’s general validity. We used a meta-analysis to separate the effects of individual quality (positive survival/reproduction correlation) from the costs of reproduction (negative survival/reproduction correlation) using studies of reproductive effort and parental survival in birds. Experimental enlargement of brood size caused reduced parental survival. However, the effect size of brood size manipulation was small and opposite to the effect of phenotypic quality, as we found that individuals that naturally produced larger clutches also survived better. The opposite effects on parental survival in experimental and observational studies of reproductive effort provides the first meta-analytic evidence for theory suggesting that quality differences mask trade-offs. Fitness projections using the overall effect size revealed that reproduction presented negligible costs, except when reproductive effort was forced beyond the maximum level observed within species, to that seen between species. We conclude that there is little support for the most fundamental life-history trade-off, between reproductive effort and survival, operating within a population. We suggest that within species, the fitness landscape of the reproduction–survival trade-off is flat until it reaches the boundaries of the between-species fast–slow life-history continuum. Our results provide a quantitative explanation as to why the costs of reproduction are not apparent and why variation in reproductive effort persists within species.
Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment
Authors: Urbancokova Alexandra , Hornofova Terezie , Novak Josef , Salajkova Sarka Andrs , Stemberkova Hubackova Sona , Uvizl Alena , Buchtova Tereza , Mistrik Martin , McStay Brian , Hodny Zdenek , Bartek Jiri , Vasicova Pavla
Published: October 2024

PML, a multifunctional protein, is crucial for forming PML-nuclear bodies involved in stress responses. Under specific conditions, PML associates with nucleolar caps formed after RNA polymerase I (RNAPI) inhibition, leading to PML-nucleolar associations (PNAs). This study investigates PNAs-inducing stimuli by exposing cells to various genotoxic stresses. We found that the most potent inducers of PNAs introduced topological stress and inhibited RNAPI. Doxorubicin, the most effective compound, induced double-strand breaks (DSBs) in the rDNA locus. PNAs co-localized with damaged rDNA, segregating it from active nucleoli. Cleaving the rDNA locus with I-PpoI confirmed rDNA damage as a genuine stimulus for PNAs. Inhibition of ATM, ATR kinases, and RAD51 reduced I-PpoI-induced PNAs, highlighting the importance of ATM/ATR-dependent nucleolar cap formation and homologous recombination (HR) in their triggering. I-PpoI-induced PNAs co-localized with rDNA DSBs positive for RPA32-pS33 but deficient in RAD51, indicating resected DNA unable to complete HR repair. Our findings suggest that PNAs form in response to persistent rDNA damage within the nucleolar cap, highlighting the interplay between PML/PNAs and rDNA alterations due to topological stress, RNAPI inhibition, and rDNA DSBs destined for HR. Cells with persistent PNAs undergo senescence, suggesting PNAs help avoid rDNA instability, with implications for tumorigenesis and aging.
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons
Authors: Shore Amy N , Li Keyong , Safari Mona , Qunies Alshaima'a M , Spitznagel Brittany D , Weaver C David , Emmitte Kyle , Frankel Wayne , Weston Matthew C
Published: October 2024

More than 20 recurrent missense gain-of-function (GOF) mutations have been identified in the sodium-activated potassium (KNa) channel gene KCNT1 in patients with severe developmental and epileptic encephalopathies (DEEs), most of which are resistant to current therapies. Defining the neuron types most vulnerable to KCNT1 GOF will advance our understanding of disease mechanisms and provide refined targets for precision therapy efforts. Here, we assessed the effects of heterozygous expression of a Kcnt1 GOF variant (Kcnt1Y777H) on KNa currents and neuronal physiology among cortical glutamatergic and GABAergic neurons in mice, including those expressing vasoactive intestinal polypeptide (VIP), somatostatin (SST), and parvalbumin (PV), to identify and model the pathogenic mechanisms of autosomal dominant KCNT1 GOF variants in DEEs. Although the Kcnt1Y777H variant had no effects on glutamatergic or VIP neuron function, it increased subthreshold KNa currents in both SST and PV neurons but with opposite effects on neuronal output; SST neurons became hypoexcitable with a higher rheobase current and lower action potential (AP) firing frequency, whereas PV neurons became hyperexcitable with a lower rheobase current and higher AP firing frequency. Further neurophysiological and computational modeling experiments showed that the differential effects of the Kcnt1Y777H variant on SST and PV neurons are not likely due to inherent differences in these neuron types, but to an increased persistent sodium current in PV, but not SST, neurons. The Kcnt1Y777H variant also increased excitatory input onto, and chemical and electrical synaptic connectivity between, SST neurons. Together, these data suggest differential pathogenic mechanisms, both direct and compensatory, contribute to disease phenotypes, and provide a salient example of how a pathogenic ion channel variant can cause opposite functional effects in closely related neuron subtypes due to interactions with other ionic conductances.
Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression
Authors: Chen Zulong , Wang Xin , Gao Xinlei , Arslanovic Nina , Chen Kaifu , Tyler Jessica K
Published: October 2024

In response to DNA double-strand damage, ongoing transcription is inhibited to facilitate accurate DNA repair while transcriptional recovery occurs after DNA repair is complete. However, the mechanisms at play and the identity of the transcripts being regulated in this manner are unclear. In contrast to the situation following UV damage, we found that transcriptional recovery after ionizing radiation (IR) occurs in a manner independent of the HIRA histone chaperone. Sequencing of the nascent transcripts identified a programmed transcriptional response, where certain transcripts and pathways are rapidly downregulated after IR, while other transcripts and pathways are upregulated. Specifically, most of the loss of nascent transcripts occurring after IR is due to inhibition of transcriptional initiation of the highly transcribed histone genes and the rDNA. To identify factors responsible for transcriptional inhibition after IR in an unbiased manner, we performed a whole genome gRNA library CRISPR/Cas9 screen. Many of the top hits on our screen were factors required for protein neddylation. However, at short times after inhibition of neddylation, transcriptional inhibition still occurred after IR, even though neddylation was effectively inhibited. Persistent inhibition of neddylation blocked transcriptional inhibition after IR, and it also leads to cell cycle arrest. Indeed, we uncovered that many inhibitors and conditions that lead to cell cycle arrest in G1 or G2 phase also prevent transcriptional inhibition after IR. As such, it appears that transcriptional inhibition after IR occurs preferentially at highly expressed genes in cycling cells.
The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis
Authors: Brattig-Correia Rion , Almeida Joana M , Wyrwoll Margot Julia , Julca Irene , Sobral Daniel , Misra Chandra Shekhar , Di Persio Sara , Guilgur Leonardo Gastón , Schuppe Hans-Christian , Silva Neide , Prudêncio Pedro , Nóvoa Ana , Leocádio Ana S , Bom Joana , Laurentino Sandra , Mallo Moises , Kliesch Sabine , Mutwil Marek , Rocha Luis M , Tüttelmann Frank , Becker Jörg D , Navarro-Costa Paulo
Published: October 2024

Male germ cells share a common origin across animal species, therefore they likely retain a conserved genetic program that defines their cellular identity. However, the unique evolutionary dynamics of male germ cells coupled with their widespread leaky transcription pose significant obstacles to the identification of the core spermatogenic program. Through network analysis of the spermatocyte transcriptome of vertebrate and invertebrate species, we describe the conserved evolutionary origin of metazoan male germ cells at the molecular level. We estimate the average functional requirement of a metazoan male germ cell to correspond to the expression of approximately 10,000 protein-coding genes, a third of which defines a genetic scaffold of deeply conserved genes that has been retained throughout evolution. Such scaffold contains a set of 79 functional associations between 104 gene expression regulators that represent a core component of the conserved genetic program of metazoan spermatogenesis. By genetically interfering with the acquisition and maintenance of male germ cell identity, we uncover 161 previously unknown spermatogenesis genes and three new potential genetic causes of human infertility. These findings emphasize the importance of evolutionary history on human reproductive disease and establish a cross-species analytical pipeline that can be repurposed to other cell types and pathologies.
Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices
Authors: Liu Yanqi , Bech Pol , Tamura Keita , Délez Lucas T , Crochet Sylvain , Petersen Carl CH
Published: October 2024

Long-range axonal projections of diverse classes of neocortical excitatory neurons likely contribute to brain-wide interactions processing sensory, cognitive and motor signals. Here, we performed light-sheet imaging of fluorescently labeled axons from genetically defined neurons located in posterior primary somatosensory barrel cortex and supplemental somatosensory cortex. We used convolutional networks to segment axon-containing voxels and quantified their distribution within the Allen Mouse Brain Atlas Common Coordinate Framework. Axonal density was analyzed for different classes of glutamatergic neurons using transgenic mouse lines selectively expressing Cre recombinase in layer 2/3 intratelencephalic projection neurons (Rasgrf2-dCre), layer 4 intratelencephalic projection neurons (Scnn1a-Cre), layer 5 intratelencephalic projection neurons (Tlx3-Cre), layer 5 pyramidal tract projection neurons (Sim1-Cre), layer 5 projection neurons (Rbp4-Cre), and layer 6 corticothalamic neurons (Ntsr1-Cre). We found distinct axonal projections from the different neuronal classes to many downstream brain areas, which were largely similar for primary and supplementary somatosensory cortices. Functional connectivity maps obtained from optogenetic activation of sensory cortex and wide-field imaging revealed topographically organized evoked activity in frontal cortex with neurons located more laterally in somatosensory cortex signaling to more anteriorly located regions in motor cortex, consistent with the anatomical projections. The current methodology therefore appears to quantify brain-wide axonal innervation patterns supporting brain-wide signaling.
RNA tertiary structure and conformational dynamics revealed by BASH MaP
Authors: Oleynikov Maxim , Jaffrey Samie R
Published: October 2024

The functional effects of an RNA can arise from complex three-dimensional folds known as tertiary structures. However, predicting the tertiary structure of an RNA and whether an RNA adopts distinct tertiary conformations remains challenging. To address this, we developed BASH MaP, a single-molecule dimethyl sulfate (DMS) footprinting method and DAGGER, a computational pipeline, to identify alternative tertiary structures adopted by different molecules of RNA. BASH MaP utilizes potassium borohydride to reveal the chemical accessibility of the N7 position of guanosine, a key mediator of tertiary structures. We used BASH MaP to identify diverse conformational states and dynamics of RNA G-quadruplexes, an important RNA tertiary motif, in vitro and in cells. BASH MaP and DAGGER analysis of the fluorogenic aptamer Spinach reveals that it adopts alternative tertiary conformations which determine its fluorescence states. BASH MaP thus provides an approach for structural analysis of RNA by revealing previously undetectable tertiary structures.