bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Path Planning for the Differential Drive Mobile Robot Based on Online Metaheuristic Optimization
Authors: Rodríguez-Molina Alejandro , Herroz-Herrera Axel , Aldape-Pérez Mario , Flores-Caballero Geovanni , Antón-Vargas Jarvin Alberto
Published: October 2022

Mobile robots are relevant dynamic systems in recent applications. Path planning is an essential task for these robots since it allows them to move from one location to another safely and at an affordable cost. Path planning has been studied extensively for static scenarios. However, when the scenarios are dynamic, research is limited due to the complexity and high cost of continuously re-planning the robot’s movements to ensure its safety. This paper proposes a new, simple, reliable, and affordable method to plan safe and optimized paths for differential mobile robots in dynamic scenarios. The method is based on the online re-optimization of the static parameters in the state-of-the-art deterministic path planner Bug0. Due to the complexity of the dynamic path planning problem, a metaheuristic optimization approach is adopted. This approach utilizes metaheuristics from evolutionary computation and swarm intelligence to find the Bug0 parameters when the mobile robot is approaching an obstacle. The proposal is tested in simulation, and well-known metaheuristic methods are compared, including Differential Evolution (DE), the Genetic Algorithm (GA), and Particle Swarm Optimization (PSO). The dynamic planner based on PSO generates paths with the best performances. In addition, the results of the PSO-based planner are compared with different Bug0 configurations, and the former is shown to be significantly better.
Interest Rate Based on The Lie Group SO(3) in the Evidence of Chaos
Authors: Bildirici Melike , Ucan Yasemen , Lousada Sérgio
Published: October 2022

This paper aims to test the structure of interest rates during the period from 1 September 1981 to 28 December 2020 by using Lie algebras and groups. The selected period experienced substantial events impacting interest rates, such as the economic crisis, the military intervention of the USA in Iraq, and the COVID-19 pandemic, in which economies were in lockdown. These conditions caused the interest rate to have a nonlinear structure, chaotic behavior, and outliers. Under these conditions, an alternative method is proposed to test the random and nonlinear structure of interest rates to be evolved by a stochastic differential equation captured on a curved state space based on Lie algebras and group. Then, parameter estimates of this equation were obtained by OLS, NLS, and GMM estimators (hereafter, LieNLS, LieOLS, and LieGMM, respectively). Therefore, the interest rates that possess nonlinear structures and/or chaotic behaviors or outliers were tested with LieNLS, LieOLS, and LieGMM. We compared our LieNLS, LieOLS, and LieGMM results with the traditional OLS, NLS, and GMM methods, and the results favor the improvement achieved by the proposed LieNLS, LieOLS, and LieGMM in terms of the RMSE and MAE in the out-of-sample forecasts. Lastly, the Lie algebras with NLS estimators exhibited the lowest RMSE and MAE followed by the Lie algebras with GMM, and the Lie algebras with OLS, respectively.
Successful Interventional Management of Life-Threatening Bleeding after Oocyte Retrieval: A Case Report and Review of the Literature
Authors: Tokue Hiroyuki , Tokue Azusa , Tsushima Yoshito
Published: October 2022

Life-threatening bleeding after oocyte retrieval is unusual. We report a case of massive vaginal bleeding requiring transcatheter arterial embolization (TAE) after transvaginal US-directed follicle aspiration for oocyte retrieval and provide a brief review of cases in which the pseudoaneurysm of the injured artery was managed with a TAE approach. A 40-year-old woman presented massive vaginal bleeding after transvaginal ultrasonography-directed follicle aspiration for oocyte retrieval. Contrast-enhanced computed tomography revealed active bleeding from the uterine ostium. Transcatheter arterial embolization was performed for a pseudoaneurysm of the right pudendal artery to manage the hemorrhage. Potentially life-threatening bleeding should be recognized as a rare complication after oocyte retrieval to promptly establish the diagnosis and preserve the uterus.
Central versus Peripheral CTEPH—Clinical and Hemodynamic Specifications
Authors: Kaldararova Monika , Simkova Iveta , Bohacekova Marcela , Reptova Adriana , Hlavata Tereza , Pacak Jozef , Lindner Jaroslav , Jansa Pavel
Published: October 2022

Background and Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a chronic progressive disease, resulting from persistent arterial obstruction combined with small-vessel remodeling. Central and peripheral CTEPH are distinguished, according to the dominant lesion’s location. This is important for surgical or percutaneous interventional assessment or for medical treatment. Material and Methods: Eighty-one patients (51 male/30 female) with confirmed CTEPH were analyzed, while the CENTRAL type included 51 patients (63%) and the PERIPHERAL type 30 patients (37%). Results: A significant difference in CENTRAL type vs. PERIPHERAL type was determined in gender (male 72.5% vs. 46.7%; p = 0.0198). No difference was found in age, functional status, or echocardiographic parameters. Invasive hemodynamic parameters showed a significant difference in mean pulmonary arterial pressure (46 vs. 58 mmHg; p = 0.0002), transpulmonary gradient (34 vs. 47 mmHg; p = 0.0005), and cardiac index (2.04 vs. 2.5 L.min.m2; p = 0.02) but not in pulmonary vascular resistance. Risk factors showed a significant difference only in acute pulmonary embolism (93.8% vs. 60%; p = 0.0002) and malignancy (2% vs. 13.3%; p = 0.0426). Conclusions: Our study showed hemodynamic differences between CENTRAL type vs. PERIPHERAL type CTEPH with a worse hemodynamic picture in CENTRAL form. This may indicate a different pathophysiological response and/or possible additional influences contributing especially to the peripheral pulmonary bed affection.
The Oncological Implication of Sentinel Lymph Node in Early Cervical Cancer: A Meta-Analysis of Oncological Outcomes and Type of Recurrences
Authors: Ronsini Carlo , De Franciscis Pasquale , Carotenuto Raffaela Maria , Pasanisi Francesca , Cobellis Luigi , Colacurci Nicola
Published: October 2022

Background and Objectives: Pelvic lymphadenectomy has been associated with radical hysterectomy for the treatment of early Cervical Cancer (ECC) since 1905. However, some complications are related to this technique, such as lymphedema and nerve damage. In addition, its clinical role is controversial. For this reason, the sentinel lymph node (SLN) has found increasing use in clinical practice over time. Oncologic safety, however, is debated, and there is no clear evidence in the literature regarding this. Therefore, our meta-analysis aims to schematically analyze the current scientific evidence to investigate the non-inferiority of SLN versus PLND regarding oncologic outcomes. Materials and Methods: Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched the PubMed and Scopus databases in June 2022 since their early first publications. We made no restrictions on the country. We considered only studies entirely published in English. We included studies containing Disease-Free Survival (DFS), Overall Survival (OS), Recurrence Rate (RR), and site of recurrence data. We used comparative studies for meta-analysis. We registered this meta-analysis to the PROSPERO site for meta-analysis with protocol number CRD42022316650. Results: Twelve studies fulfilled inclusion criteria. The four comparative studies were enrolled in meta-analysis. Patients were analyzed concerning Sentinel Lymph Node Biopsy (SLN) and compared with Bilateral Pelvic Systematic Lymphadenectomy (PLND) in early-stage Cervical Cancer (ECC). Meta-analysis highlighted no differences in oncological safety between these two techniques, both in DFS and OS. Moreover, most of the sites of recurrences in the SLN group seemed not to be correlated with missed lymphadenectomy. Conclusions: Data in the literature do not seem to show clear oncologic inferiority of SLN over PLND. On the contrary, the higher detection rate of positive lymph nodes and the predominance of no lymph node recurrences give hope that this technique may equal PLND in oncologic terms, improving its morbidity profile.
Patterns of Locus of Control in People Suffering from Heart Failure: An Approach by Clustering Method
Authors: Siennicka Agnieszka , Pondel Maciej , Urban Szymon , Jankowska Ewa Anita , Ponikowska Beata , Uchmanowicz Izabella
Published: October 2022

Background and Objectives: The assumption of responsibility in dealing with chronic diseases is of relevance in a resource-oriented and not only deficit-oriented medicine, especially in dealing with chronic diseases, including patients with chronic heart failure. The aim of the present study is to examine, based on the model of “locus of control”, whether there are different patterns that would be relevant for a more targeted education and support of self-management in dealing with heart failure. Materials and Methods: For this purpose, a sample (n = 758) from 11 Polish cardiology centers have been assessed using the standardized self-assessment scale Multidimensional Health Locus of Control (MHLC), consisting of three dimensions: (i) internal localization of health control; (ii) external control by powerful others; (iii) external control by chance. Results: Using these three criteria, nine different clusters were extracted (mean size: 84 ± 33 patients, min 31, max 129). Three clusters included over 100 patients, whereas only two included less than 50 people. Only one cluster gathered 42 patients who will be able to cooperate with professionals in the most fruitful way. There were two clusters, including patients with beliefs related to the risk of ignoring professional recommendations. Clusters where patients declared beliefs about others’ control with low internal control should also be provided with specific help. Conclusions: The division into clusters revealed significant variability of belief structures about health locus of control within the analyzed group. The presented methodological approach may help adjust education and motivation to a selected constellation of beliefs as a compromise between group-oriented vs. individual approach.
Second-Line Chemotherapy in Elderly Patients with Advanced Biliary Tract Cancer: A Multicenter Real-World Study
Authors: Rizzo Alessandro , Salati Massimiliano , Frega Giorgio , Merz Valeria , Caputo Francesco , Di Federico Alessandro , Palloni Andrea , Carloni Riccardo , Ricci Angela Dalia , Gadaleta-Caldarola Gennaro , Messina Carlo , Spallanzani Andrea , Gelsomino Fabio , Benatti Stefania , Luppi Gabriele , Melisi Davide , Dominici Massimo , Brandi Giovanni
Published: October 2022

Objectives: The ABC-06 and the NIFTY trials recently established the role of second-line chemotherapy (2L) in patients with advanced biliary tract cancer (BTC). Our real-world study aimed to explore 2L in BTC patients aged ≥ 70 years old and to compare their outcomes with younger subjects. Methods: Institutional registries across three academic medical centers were retrospectively reviewed. The Kaplan–Meier methods were used to estimate survival, and the log-rank test was used to make comparisons. Results: A total of 190 BTC patients treated with 2L were identified and included in the analysis. Among them, 52 (27.3%) were aged ≥ 70 years (range 70–87 years). No statistically significant differences in both median overall survival (mOS) and median progression-free survival (mPFS) were recorded between the elderly and younger patients. Absolute lymphocyte count < 1000/mmc (p < 0.001) and albumin level < 3 g/dL (p < 0.001) were independently associated with worse prognoses. Conclusions: The results of this real-world study suggest that for patients aged ≥ 70 years, 2L could be equally effective for younger patients with survival outcomes aligned to those from the ABC-06 and NIFTY trials. The delivery of 2L should be carefully evaluated and monitored in this patient subset.
Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
Authors: Zgodova Arina , Pavlova Svetlana , Nekrasova Anastasia , Boyarkin Dmitriy , Pinelis Vsevolod , Surin Alexander , Bakaeva Zanda
Published: October 2022

It is considered that glutamate excitotoxicity may be a major factor in the pathological death of neurons and mediate the development of neurodegenerative diseases in humans. Here, we show that isoliquiritigenin (ILG) at a concentration of 0.5–5 µM protects primary neuroglial cell culture from glutamate-induced death (glutamate 100 µM). ILG (1 µM) prevented a sharp increase in [Ca2+]i and a decrease in mitochondrial potential (ΔΨm). With the background action of ILG (1–5 µM), there was an increase in oxygen consumption rate (OCR) in response to glutamate, as well as in reserve respiration. The neuroprotective effect of ILG (5 µM) was accompanied by an increase in non-mitochondrial respiration. The results show that ILG can protect cortical neurons from death by preventing the development of calcium deregulation and limiting mitochondrial dysfunction caused by a high dose of glutamate. We hypothesize that ILG will be useful in drug development for the prevention or treatment of neurodegenerative diseases accompanied by glutamate excitotoxicity.
Controlled Covalent Functionalization of ZIF-90 for Selective CO2 Capture & Separation
Authors: Usman Muhammad , Khan Mohd Yusuf , Anjum Tanzila , Khan Asim Laeeq , Hoque Bosirul , Helal Aasif , Hakeem Abbas Saeed , Al-Maythalony Bassem A.
Published: October 2022

Mixed Matrix Membranes (MMM) with enhanced selectivity and permeability are preferred for gas separations. The porous metal-organic frameworks (MOFs) materials incorporated in them play a crucial part in improving the performance of MMM. In this study, Zeolitic imidazolate frameworks (ZIF-90) are selected to fabricate Polyetherimide (PEI) MMMs owing to their lucrative structural and chemical properties. This work reports new controlled post-synthetic modifications of ZIF-90 (50-PSM-ZIF-90) with ethanolamine to control the diffusion and uptake of CO2. Physical and chemical properties of ZIF-90, such as stability and presence of aldehyde functionality in the imidazolate linker, allow for easy modulation of the ZIF-90 pores and window size to tune the gas transport properties across ZIF-90-based membranes. Effects of these materials were investigated on the performance of MMMs and compared with pure PEI membranes. Performance of the MMMs was evaluated in terms of permeability of different gases and selective separation of CO2 and H2 gas. Results presented that the permeability of all membranes was in the following order, i.e., P(H2) > P(CO2) > P(O2) > P(CH4) > P(C2H6) > P(C3H8) > P(N2), demonstrating that kinetic gas diffusion is the predominant gas transport mode in these membranes. Among all the membranes, permeability of pure PEI membrane was highest for all gases due to the uniform porous morphology. The pure PEI membrane showed highest permeability of H2, which is 486.5 Barrer, followed by 49 Barrer for O2, 29 Barrer for N2, 142 Barrer for CO2, 41 Barrer for CH4, 40 Barrer for C2H6 and 39.6 Barrer for C3H8. Results also confirm the superiority of controlled PSM-ZIF-90-PEI membrane over the pure PEI and ZIF-90-PEI membranes in CO2 and H2 separation performance. The 50-PSM-ZIF-90 PEI membrane exhibited a 20% increase in CO2 separation from methane and a 26% increase over nitrogen compared to the ZIF-90-PEI membrane. The 50-PSM-ZIF-90 PEI membrane showed 15% more H2/O2 separation and 9% more H2/CH4 separation than ZIF-90 PEI membrane. Overall, this study represents the role of controlled PSM in enhancing the property of new materials like ZIF and its application in MMMs fabrication to develop a promising approach for the CO2 capture and separation.
The Role of Mycorrhizal-Assisted Phytomining in the Recovery of Raw Materials from Mine Wastes
Authors: Scotti Adalgisa , Silvani Vanesa Analía , Juarez Natalia Andrea , Godeas Alicia Margarita , Ubaldini Stefano
Published: October 2022

In recent years, critical and secondary raw materials (CRMs and SRMs, respectively) have received great interest within the circular economy model. In this work, the mycorrhizal-assisted phytomining (MAP) system, composed of Helianthus annuus–arbuscular mycorrhizal fungus Rhizophagus intraradices–Zn-volcanic ashes, was applied in bioreactors for the recovery of CRMs (Sr, P) and SRMs (Cr, Zn, Cu, Mn, Rb, Ni) from mining wastes of the Los Cóndores mine (Argentina). Our results showed high bioaccumulation of Sr, P, Mn, and Zn in the aerial tissues, and a high root-to-shoot translocation for Mn (4.02) > Sr > P > Rb > Zn (0.84). Mycorrhization treatment increased the root-to-leaf translocation for Cr and P and prevented translocation towards flower tissues in most elements. The estimated bioextracting potential of the MAP system (290 plants) in a vegetable depuration module (VDM) ranged from 158 mg/m3 P > Zn > Mn > 15.1 mg/m3 Sr. We demonstrated a promising and cost-effective biotechnology applicable in agronomical practices, given the exclusion of toxic elements in flower parts, as well as for the recovery of CRMs and SRMs by hydrometallurgy from plant biomass.
Recent Progress of Electrode Architecture for MXene/MoS2 Supercapacitor: Preparation Methods and Characterizations
Authors: Kosnan Muhammad Akmal , Azam Mohd Asyadi , Safie Nur Ezyanie , Munawar Rose Farahiyan , Takasaki Akito
Published: October 2022

Since their discovery, MXenes have conferred various intriguing features because of their distinctive structures. Focus has been placed on using MXenes in electrochemical energy storage including a supercapacitor showing significant and promising development. However, like other 2D materials, MXene layers unavoidably experience stacking agglomeration because of its great van der Waals forces, which causes a significant loss of electrochemically active sites. With the help of MoS2, a better MXene-based electrodecan is planned to fabricate supercapacitors with the remarkable electrochemical performance. The synthesis of MXene/MoS2 and the ground effects of supercapacitors are currently being analysed by many researchers internationally. The performance of commercial supercapacitors might be improved via electrode architecture. This analysis will support the design of MXene and MoS2 hybrid electrodes for highly effective supercapacitors. Improved electrode capacitance, voltage window and energy density are discussed in this literature study. With a focus on the most recent electrochemical performance of both MXene and MoS2-based electrodes and devices, this review summarises recent developments in materials synthesis and its characterisation. It also helps to identify the difficulties and fresh possibilities MXenes MoS2 and its hybrid heterostructure in this developing field of energy storage. Future choices for constructing supercapacitors will benefit from this review. This review examines the newest developments in MXene/MoS2 supercapacitors, primarily focusing on compiling literature from 2017 through 2022. This review also presents an overview of the design (structures), recent developments, and challenges of the emerging electrode materials, with thoughts on how well such materials function electrochemically in supercapacitors.
Incidence of Common Herpesviruses in Colonic Mucosal Biopsies Following Hematopoietic Stem Cell Transplantation
Authors: Goloshchapov Oleg V. , Shvetsov Alexander N. , Chukhlovin Alexey B. , Spiridonova Anna A. , Vladovskaya Maria D. , Zubarovskaya Ludmila S. , Kulagin Alexander D.
Published: October 2022

Intestinal complications are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, only scarce data concern herpesvirus incidence in the colonic mucosa post-HSCT. Our purpose was to assess the frequency and clinical significance of cytomegalovirus (CMV), Epstein–Barr virus (EBV), human herpesvirus type 6 (HHV6), and herpes simplex virus (HSV) in the colonic mucosa post-HSCT. The study group included 119 patients of different ages, mostly with leukemias and lymphomas, subjected to allo-HSCT from haploidentical related (48%) or HLA-compatible donors (52%). In total, 155 forceps biopsies of the colonic mucosa were taken in cases of severe therapy-resistant intestinal syndrome post-HSCT. Most samples were taken from the descending, sigmoid, and transverse colon. Intestinal GVHD or local infections were assessed clinically and by histology. EBV, CMV, HSV, and HHV6 were tested in colonic mucosal lysates with commercial PCR assays. HSV was found in <8% of colonic samples, along with high HHV6 and CMV positivity (up to 62% and 35%, respectively) and a higher EBV incidence at 5–6 months post-HSCT (35%). For CMV and EBV, significant correlations were revealed between their rates of detection in blood and colonic mucosa (r = 0.489 and r = 0.583; p < 0.05). No significant relationships were found between the presence of herpesviruses and most patients’ characteristics. EBV positivity in colonic samples was correlated with delayed leukocyte and platelet recovery post-HSCT. Higher EBV frequency in the colonic mucosa was found in deceased patients (56% versus 21%, p = 0.02). The correlations among EBV positivity in the colon, lethality rates and delayed hematopoietic reconstitution suggest some relationship with systemic and local EBV reactivation post-transplant.
Pathogenic Escherichia coli, Salmonella spp. and Campylobacter spp. in Two Natural Conservation Centers of Wildlife in Portugal: Genotypic and Phenotypic Characterization
Authors: Pista Angela , Silveira Leonor , Ribeiro Sofia , Fontes Mariana , Castro Rita , Coelho Anabela , Furtado Rosália , Lopes Teresa , Maia Carla , Mixão Verónica , Borges Vítor , Sá Ana , Soeiro Vanessa , Correia Cristina Belo , Gomes João Paulo , Saraiva Margarida , Oleastro Mónica , Batista Rita
Published: October 2022

Human–wildlife coexistence may increase the potential risk of direct transmission of emergent or re-emergent zoonotic pathogens to humans. Intending to assess the occurrence of three important foodborne pathogens in wild animals of two wildlife conservation centers in Portugal, we investigated 132 fecal samples for the presence of Escherichia coli (Shiga toxin-producing E. coli (STEC) and non-STEC), Salmonella spp. and Campylobacter spp. A genotypic search for genes having virulence and antimicrobial resistance (AMR) was performed by means of PCR and Whole-Genome Sequencing (WGS) and phenotypic (serotyping and AMR profiles) characterization. Overall, 62 samples tested positive for at least one of these species: 27.3% for STEC, 11.4% for non-STEC, 3.0% for Salmonella spp. and 6.8% for Campylobacter spp. AMR was detected in four E. coli isolates and the only Campylobacter coli isolated in this study. WGS analysis revealed that 57.7% (30/52) of pathogenic E. coli integrated genetic clusters of highly closely related isolates (often involving different animal species), supporting the circulation and transmission of different pathogenic E. coli strains in the studied areas. These results support the idea that the health of humans, animals and ecosystems are interconnected, reinforcing the importance of a One Health approach to better monitor and control public health threats.
A Review of Sensor-Based Sorting in Mineral Processing: The Potential Benefits of Sensor Fusion
Authors: Peukert Dylan , Xu Chaoshui , Dowd Peter
Published: October 2022

Sensor-based sorting techniques offer the potential to improve ore grades and reduce the amount of waste material processed. Previous studies show that sensor-based sorting can reduce energy, water and reagent consumption and fine waste production by discarding waste prior to further processing. In this literature review, recent investigations of sensor-based sorting and the fundamental mechanisms of the main sorting techniques are evaluated to inform optimal sensor selection. Additionally, the fusing of data from multiple sensing techniques to improve characterization of the sensed material and hence sorting capability is investigated. It was found that the key to effective implementation of sensor-based sorting is the selection of a sensing technique which can sense a characteristic capable of separating ore from waste with a sampling distribution sufficient for the considered sorting method. Classes of potential sensor fusion sorting applications in mineral processing are proposed and illustrated with example cases. It was also determined that the main holdup for implementing sensor fusion is a lack of correlatable data on the response of multiple sensing techniques for the same ore sample. A combined approach of experimental testing supplemented by simulations is proposed to provide data to enable the evaluation and development of sensor fusion techniques.
Electrochemical Deposition of Ferromagnetic Ni Nanoparticles in InP Nanotemplates Fabricated by Anodic Etching Using Environmentally Friendly Electrolyte
Authors: Moise Călin Constantin , Mihai Geanina Valentina , Anicăi Liana , Monaico Eduard V. , Ursaki Veaceslav V. , Enăchescu Marius , Tiginyanu Ion M.
Published: October 2022

Porous InP templates possessing a thickness of up to 100 µm and uniformly distributed porosity were prepared by anodic etching of InP substrates exhibiting different electrical conductivities, involving an environmentally friendly electrolyte. Ni nanoparticles were successfully directly deposited by pulsed electroplating into prefabricated InP templates without any additional deposition of intermediary layers. The parameters of electrodeposition, including the pulse amplitude, pulse width and interval between pulses, were optimized to reach a uniform metal deposition covering the inner surface of the nanopores. The electrochemical dissolution of n-InP single crystals was investigated by measuring the current–voltage dependences, while the Ni-decorated n-InP templates have been characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The proposed technology is expected to be of interest for sensing and photocatalytic applications, as well as for the exploration of their plasmonic and magnetic properties.
Electrophysical Properties and Structure of Natural Disordered sp2 Carbon
Authors: Golubev Yevgeny A. , Antonets Igor V.
Published: October 2022

The progress in the practical use of glassy carbon materials has led to a considerable interest in understanding the nature of their physical properties. The electrophysical properties are among the most demanded properties. However, obtaining such materials is associated with expensive and dirty processes. In nature, in the course of geological processes, disordered sp2 carbon substances were formed, the structure of which is in many respects similar to the structure of glassy carbon and black carbon, and the electrical properties are distinguished by a high-energy storage potential and a high efficiency of shielding electromagnetic radiation. Given the huge natural reserves of such carbon (for example, in the shungite rocks of Karelia) and the relative cheapness and ease of producing materials from it, the study of potential technological applications and the disclosure of some unique electrophysical properties are of considerable interest. In this paper, we present an overview of recent studies on the structure, electrophysical properties, and technological applications of natural disordered sp2 carbon with the addition of novel authors’ results.
Development and Validation of an Eating-Related Eco-Concern Questionnaire
Authors: Qi Baiyu , Presseller Emily K. , Cooper Gabrielle E. , Kapadia Avantika , Dumain Alexis S. , Jayawickreme Shantal M. , Bulik-Sullivan Emily C. , van Furth Eric F. , Thornton Laura M. , Bulik Cynthia M. , Munn-Chernoff Melissa A.
Published: October 2022

Eco-concern, the distress experienced relating to climate change, is associated with mental health, yet no study has examined disordered eating related to eco-concern. This study developed and validated a 10-item scale assessing Eating-Related Eco-Concern (EREC). Participants (n = 224) completed the EREC, Climate Change Worry Scale (CCWS), and Eating Disorder Examination-Questionnaire (EDE-Q). Construct validity, convergent validity, and internal consistency were evaluated. Sex differences in EREC were evaluated using t-tests. Associations among the EREC, CCWS, and EDE-Q were evaluated using linear regression models. Sensitivity analyses were conducted in individuals below EDE-Q global score clinical cut-offs. Factor analysis suggested that all items loaded adequately onto one factor. Pearson’s correlation and Bland–Altman analyses suggested strong correlation and acceptable agreement between the EREC and CCWS (r = 0.57), but weak correlation and low agreement with the EDE-Q global score (r = 0.14). The EREC had acceptable internal consistency (α = 0.88). No sex difference was observed in the EREC in the full sample; females had a significantly higher mean score than males in sensitivity analysis. The EREC was significantly positively associated with the CCWS and EDE-Q global and shape concern scores, but not in sensitivity analysis. The EREC is a brief, validated scale that can be useful to screen for eating-related eco-concern.
Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis
Authors: Su Meiming , Zhao Wenqi , Li Yujie , Li Hong , Xu Suowen , Weng Jianping
Published: October 2022

Atherosclerosis is a chronic inflammatory vascular disease in which endothelial cells play an important role in maintaining vascular homeostasis. Endotheliitis caused by endothelial dysfunction (ED) is the key cause for the development of cardiovascular and cerebrovascular diseases as well as other vascular system diseases. Resveratrol (RES), a multi-functional polyphenol present in edible plants and fruits, prevents cardiovascular disease by regulating a variety of athero-relevant signaling pathways. By transcriptome profiling of RES-treated human umbilical vein endothelial cells (HUVECs) and in-depth bioinformatic analysis, we observed that differentially expressed genes (DEGs) were enriched in KEGG pathways of fluid shear stress and atherosclerosis, suggesting that the RES may serve as a good template for a shear stress mimetic drug that hold promise in combating atherosclerosis. A heat map and multiple datasets superimposed screening revealed that RES significantly down-regulated phosphatase and actin modulator 1 (PHACTR1), a pivotal coronary artery disease risk gene associated with endothelial inflammation and polyvascular diseases. We further demonstrate that RES down-regulated the gene and protein expression of PHACTR1 and inhibited TNF-α-induced adhesion of THP-1 monocytes to activated endothelial cells via suppressing the expression of PHACTR1. Taken together, our study reveals that PHACTR1 represents a new molecular target for RES to maintain endothelial cell homeostasis and prevent atherosclerotic cardiovascular disease.
Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice
Authors: Bae Yunji , Kim Taeyoung , Park Nojune , Choi Sangho , Yi Dongkeun , Soto Silvia , Zamora Nelson , Kim Sunam , Yang Minhye
Published: October 2022

The genus Daphnopsis has been traditionally used as a purgative, diuretic, stimulant, and psoriasis treatment. In this study, the anti-AD (atopic dermatitis) activities of the Daphnopsis costaricensis EtOH extract (DCE) were investigated in an oxazolone (OX)-induced mouse model of AD, and the anti-inflammatory effects of its active compounds were confirmed in PI-sensitized or IgE/DNP-BSA-sensitized RBL-2H3 cells. DCE improved the symptoms of OX-induced inflammatory dermatitis (swelling, erythema, and increased ear thickening) in OX-induced BALB/c mice ears and reduced epidermal thickness and mast cell infiltration. Eleven flavonoid compounds were isolated from DCE, and two compounds (7,8-dimethoxyflavone and 7,2’-dimethoxyflavone) significantly inhibited IL-4 overexpression in PI-induced RBL-2H3 cells and mast cell degranulation in IgE + DNP-BSA-induced RBL-2H3 cells. Our study indicates that DCE and two compounds (7,8-dimethoxyflavone and 7,2’-dimethoxyflavone) might effectively improve inflammatory and atopic skin symptoms.
Retinoic Acid: The Autacoid for All Seasons
Authors: Napoli Joseph L.
Published: October 2022

All-trans-retinoic acid (RA), a metabolite of vitamin A (retinol), exerts profuse actions that enable multiple aspects of reproduction, embryonic development and post-natal regulation of energy metabolism, glucoregulatory control, organ function, and of the skeletal, immune, nervous and cardiovascular systems, as well as cell proliferation vs [...]
Application of Phyto-Stimulants for Growth, Survival Rate, and Meat Quality Improvement of Tiger Shrimp (Penaeus monodon) Maintained in a Traditional Pond
Authors: Hardi Esti Handayani , Nugroho Rudi Agung , Agriandini Maulina , Rizki Muhammad , Falah Muhammad Eko Nur , Almadi Ismail Fahmy , Susmiyati Haris Retno , Diana Rita , Palupi Nurul Puspita , Saptiani Gina , Agustina Agustina , Asikin Andi Noor , Sukarti Komsanah
Published: October 2022

The tiger shrimp culture in East Borneo is commonly performed using traditional pond system management. In this work, the objective was to evaluate the application of Boesenbergia pandurata and Solanum ferox extract supplemented as feed additives considering shrimp growth, survival rate, and meat quality culture in a traditional pond. There were three dietary groups that were stocked with 300 shrimp in this study. The shrimp were maintained in a pond, separated with a 3 × 3 m2 net. The dietary treatment applied was divided into three types, namely P1, without the extracts; P2, 20 mL kg−1 dietary supplementation; and P3, 30 mL kg−1 dietary supplementation in the diet. The findings revealed that the herb extract influenced the growth rate, feed efficiency, survival rate, and meat quality of the shrimp, mainly the amino and fatty acid contents in the shrimp meat. The 30 mL kg−1 herb extract dose in group 3 showed a higher growth performance and survival rate. In group 3, 98% of the shrimp could survive until the final study period, while 96% of shrimp survived in group 2, and 70% of the shrimp survived in group 1. These findings indicate that the phytoimmune (B. pandurata and S. ferox) extract can be utilized as a feed additive to improve the growth, survival rate, and meat quality of the shrimp.
The Therapeutic Potential of Plant Polysaccharides in Metabolic Diseases
Authors: Wang Xiao-Fang , Chen Xue , Tang Yong , Wu Jian-Ming , Qin Da-Lian , Yu Lu , Yu Chong-Lin , Zhou Xiao-Gang , Wu An-Guo
Published: October 2022

Plant polysaccharides (PPS) composed of more than 10 monosaccharides show high safety and various pharmacological activities, including immunoregulatory, antitumor, antioxidative, antiaging, and other effects. In recent years, emerging evidence has indicated that many PPS are beneficial for metabolic diseases, such as cardiovascular disease (CVD), diabetes, obesity, and neurological diseases, which are usually caused by the metabolic disorder of fat, sugar, and protein. In this review, we introduce the common characteristics and functional activity of many representative PPS, emphasize the common risks and molecular mechanism of metabolic diseases, and discuss the pharmacological activity and mechanism of action of representative PPS obtained from plants including Aloe vera, Angelica sinensis, pumpkin, Lycium barbarum, Ginseng, Schisandra chinensis, Dioscorea pposite, Poria cocos, and tea in metabolic diseases. Finally, this review will provide directions and a reference for future research and for the development of PPS into potential drugs for the treatment of metabolic diseases.
Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases
Authors: Liu Fan , Qu Linkai , Li Hua , He Jiaxuan , Wang Lei , Fang Yimeng , Yan Xiaoqing , Yang Qinsi , Peng Bo , Wu Wei , Jin Libo , Sun Da
Published: October 2022

Pigmentation diseases can lead to significant color differences between the affected part and the normal part, resulting in severe psychological and emotional distress among patients. The treatment of pigmentation diseases with good patient compliance is mainly in the form of topical drugs. However, conventional hydroquinone therapy contributes to several pathological conditions, such as erythema, dryness, and skin desquamation, and requires a longer treatment time to show significant results. To address these shortcomings, natural whitening substances represented by kojic acid and arbutin have gradually become the candidate ingredients of traditional local preparations due to their excellent biological safety. This review focuses on several natural whitening substances with potential therapeutic effects in pigmentation disease and their mechanisms, and a thorough discussion has been conducted into the solution methods for the challenges involved in the practical application of natural whitening substances.
An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals
Authors: Lu Yu , Zhu Di , Le Quynh , Wang Yuji , Wang Wei
Published: October 2022

Phytantriol-based lyotropic liquid crystals (LLCs) have emerged as a new nanodrug delivery system. However, the understanding of phytantriol-based LLCs is lacking. In this study, we use NMR technology to characterize LLC formation over two months. Three samples in different phases were prepared with different hydration states. NMR data, including 1D-1H, 13C-{1H}, 2D-HSQC, HMBC, COSY, NOESY, etc., were collected. A comprehensive analysis of these NMR data was performed on the three phases of phytantriol-based LLCs. The following results were achieved from the study. First, the 1H and 13C-{1H} spectra of phytantriol were assigned. Second, the change of NMR spectra during the formation of the phases was observed, and the change of hydration was calculated for the time-dependent phase formation. Third, the correlation peaks of 2D-NOESY were used to describe the spatial relationship of lipids–water interaction and lipid–lipid interaction.
Dosage Form Modification, a Simulation Activity between Nursing and Pharmacy Students
Authors: Lim Chiao Xin , Livesay Karen , Stevens Julie , Nooney Vivek , Baverstock Katherine , Orwin Nichole , Stupans Ieva
Published: October 2022

Background: The aim of this exploratory pilot study was to evaluate student perceptions of a simulation activity involving undergraduate nursing and pharmacy students. The key question was “how do nursing and pharmacy students respond in an immersive collaborative simulation activity which involves medication dosage form modification?” Methods: One hundred nursing students participated in a simulated exercise where patients required medications for which there were barriers to administration. Fourteen pharmacy students were also present in the simulated health environment, observing the work of the nursing students and being available to provide advice regarding medication administration to the nursing students. A mixed methods approach was employed for this exploratory pilot study, where both nursing and pharmacy students were invited to complete a survey regarding the experience at the end of the simulation exercise and pharmacy students completed a reflection. Both surveys and reflections were analyzed. Results: Survey results indicated very high satisfaction regarding the exercise for both pharmacy and nursing students. Analysis of pharmacy student reflections also indicated apprehension regarding their preparedness to contribute to the exercise, enjoyment in participation, their understanding of the value of collaboration between the two groups of students, and also recognition of their need to be more prepared for such situations. Conclusion: This study assessed student perceptions and did not formally evaluate learning outcomes. The interprofessional immersive simulated learning opportunity was viewed as valuable by both nursing and pharmacy students. The immersive simulation provided teaching staff with the opportunity to develop a new approach for the teaching of dosage form modification to both nursing and pharmacy students in an interprofessional setting.
Generation of Tunable Plasmonic Vortices by Varying Wavelength of Incident Light
Authors: Bai Yihua , Zhang Qing , Yang Yuanjie
Published: October 2022

Surfaces plasmon polaritons carrying orbital angular momentum (OAM), known as plasmonic vortex, hold potential applications for on-chip information multiplexing. However, a traditional plasmonic vortex lens was usually designed for monochromatic incident light and encountered challenges in generating multiple vortices. Here, we demonstrated a wavelength-tunable plasmonic vortex generator that ameliorates these limits, relying on the simultaneous design of a geometric metasurface on an Archimedean spiral. Through this design strategy, both the topological charges and the location of vortices can be controlled with different wavelengths of incident beams. This design and concept can preserve incident wavelength information and can be further applied to integrated and high-dimensional on-chip devices.
From a Lose–Lose to a Win–Win Situation: User-Friendly Biomass Models for Acacia longifolia to Aid Research, Management and Valorisation
Authors: Ulm Florian , Estorninho Mariana , de Jesus Joana Guedes , de Sousa Prado Miguel Goden , Cruz Cristina , Máguas Cristina
Published: October 2022

Woody invasive species pose a big threat to ecosystems worldwide. Among them, Acacia longifolia is especially aggressive, fundamentally changing ecosystem structure through massive biomass input. This biomass is rarely harvested for usage; thus, these plants constitute a nuisance for stakeholders who invest time and money for control without monetary return. Simultaneously, there is an increased effort to valorise its biomass, e.g., for compost, growth substrate or as biofuel. However, to incentivise A. longifolia harvest and usage, stakeholders need to be able to estimate what can be obtained from management actions. Thus, the total biomass and its quality (C/N ratio) need to be predicted to perform cost–benefit analyses for usage and determine the level of invasion that has already occurred. Here, we report allometric biomass models for major biomass pools, as well as give an overview of biomass quality. Subsequently, we derive a simplified volume-based model (BM ~ 6.297 + 0.982 × Vol; BM = total dry biomass and Vol = plant volume), which can be applied to remote sensing data or with in situ manual measurements. This toolkit will help local stakeholders, forest managers or municipalities to predict the impact and valorisation potential of this invasive species and could ultimately encourage its management.
CsMYB Transcription Factors Participate in Jasmonic Acid Signal Transduction in Response to Cold Stress in Tea Plant (Camellia sinensis)
Authors: Han Zhaolan , Zhang Chen , Zhang Huan , Duan Yu , Zou Zhongwei , Zhou Lin , Zhu Xujun , Fang Wanping , Ma Yuanchun
Published: October 2022

Low-temperature stress is an increasing problem for the cultivation of tea (Camellia sinensis), with adverse effects on plant growth and development and subsequent negative impacts on the tea industry. Methyl jasmonate (MeJA), as a plant inducer, can improve the cold-stress tolerance in tea plants. R2R3-MYB transcription factors (TFs) are considered potentially important regulators in the resistance to cold stress in plants. However, the molecular mechanisms, by which MYB TFs via the jasmonic acid pathway respond to cold stress in the tea plant, remain unknown. In this study, physiological and biochemical assays showed that exogenous MeJA application could effectively promote ROS scavenging in the tea plant under cold stress, maintaining the stability of the cell membrane. Sixteen R2R3-MYB TFs genes were identified from the tea plant genome database. Quantitative RT-PCR analysis showed that three CsMYB genes were strongly induced under a combination of MeJA and cold-stress treatment. Subcellular localization assays suggest CsMYB45, CsMYB46, and CsMYB105 localized in the nucleus. Exogenous MeJA treatment enhanced the overexpression of CsMYB45, CsMYB46, and CsMYB105 in E. coli and improved the growth and survival rates of recombinant cells compared to an empty vector under cold stress. Yeast two-hybrid and bimolecular fluorescence complementation experiments confirmed that CsMYB46 and CsMYB105 interacted with CsJAZ3, CsJAZ10, and CsJAZ11 in the nucleus. Taken together, these results highlight that CsMYB45, CsMYB46, and CsMYB105 are not only key components in the cold-stress signal response pathway but also may serve as points of confluence for cold stress and JA signaling pathways. Furthermore, our findings provide new insight into how MYB TFs influence cold tolerance via the jasmonic acid pathway in tea and provide candidate genes for future functional studies and breeding.
Biogeography and Systematics of the Genus Axyris (Amaranthaceae s.l.)
Authors: Sukhorukov Alexander P. , Shiposha Valeriia D. , Kushunina Maria , Zaika Maxim A.
Published: October 2022

Axyris is a small genus of six species with a disjunct geographic range. Five species are present in Siberia, Central Asia, the Himalayas, and Tibet, whereas Axyris caucasica has been registered in the Central Caucasus only. Axyris species diversity is the highest in the Altai Mountains (four spp.), followed by the Tian Shan and Pamir Mountains (three spp.), and the Himalayas and Tibet (two spp.). Axyris sphaerosperma, sometimes considered endemic to Southern Siberia, in fact has a disjunct range: it is present in the lowlands of Eastern Siberia and in the Altai, Tian Shan, and Pamir Mountains. It has also been found in Mongolia and China for the first time. An updated detailed distribution of Axyris in Siberia is presented on the basis of thorough herbarium revisions. One nuclear and three plastid markers were selected for phylogenetic analysis. Divergence times were estimated using a time-calibrated Bayesian approach. Axyris shows two major clades: an Axyris amaranthoides clade and a clade including the remaining species. The latter clade consists of two subclades (A. sphaerosperma/A. caucasica and A. mira/A. prostrata + A. hybrida). The crown age for Axyris dates back to the Early Pliocene (~5.11 mya, the Zanclean). The ancestral range of Axyris covers Southern Siberia, Mongolia, NW China, and the Tian Shan/Pamir Mountains, with extensions toward Eastern Siberia, the Himalayas/Tibet, and the Caucasus. Fruit and seed characteristics of Axyris are discussed with reference to the present phylogenetic results. Closely related A. sphaerosperma and A. caucasica have the thickest seed coat among all Chenopodiaceae, and these traits have probably evolved as adaptations to extremely low winter temperatures. This reproductive peculiarity may explain the disjunct range of A. sphaerosperma, which is restricted to harsh climatic conditions.