bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of allergen-specific immunotherapy with house dust mite allergens on the quality of life in children with bronchial asthma
Authors: Trusova O. V. , Mizernitskiy Yu. L. , Trofimov V. I. , Kamaev A. V. , Platonova N. B.
Published: July 2023

Controlled studies of the impact of allergen-specific immunotherapy on the quality of life of patients provide mixed results. Purpose. To evaluate the quality-of-life dynamics in children with bronchial asthma during 3 years of treatment with allergen immunotherapy with house dust mite allergens and one year after its completion.Material and methods. In an open-label, five-year prospective study, the clinical efficacy of allergen immunotherapy and quality of life were assessed using a validated PAQLQ(S) questionnaire at the end of the baseline year (before starting allergen immunotherapy), at the end of each of allergen immunotherapy year, and at the end of the follow-up year. The study was completed by 25 patients of the main group (16 boys, 9 girls aged 8.3 [6.7; 11.5] years at inclusion) with moderate bronchial asthma in 17 children (68%), mild bronchial asthma in 8 children (32%), and 25 children of the comparison group (who received a similar amount of pharmacological therapy but not allergen immunotherapy), matched as pairs-copies to the children of the main group.Results. During the first two years of allergen immunotherapy, changes in the level of quality of life were multidirectional. By the end of the third year of allergen immunotherapy, there was a trend towards an improvement in overall quality of life and a decrease in the effect of bronchial asthma symptoms upon quality of life. A year after allergen immunotherapy completion in the main group, a significant increase in overall quality of life was noted, in comparison with the level of quality of life before the start of treatment (p=0.03) and in comparison with the level in the comparison group (p=0.046).Conclusion. The data obtained objectively indicate an increase in quality of life in children with asthma as a result of a full course of allergen immunotherapy. The achieved positive results were maintained for at least 1 year after the end of treatment.
Diagnostic significance of the extracellular matrix structures in bronchial asthma in children
Authors: Stroykova T. R. , Bashkina O. A. , Geppe N. A.
Published: July 2023

The intercellular matrix in bronchial asthma is involved in both reversible and irreversible processes of structural change. Markers of endothelial disorders, indicators of extracellular matrix structures may have diagnostic significance.Purpose. To study the clinical significance of markers of collagen genesis and plasma endothelin-1 in bronchial asthma in children, depending on the severity and duration of the disease.Material and methods. 268 patients aged from 2 years 11 months to 17 years 11 months with an established diagnosis of bronchial asthma with varying degrees of severity were examined. The ELISA method determined the serum levels of the following indicators: antibodies to type I and type III collagen, plasma endothelin.Results. There was a significantly significant increase in fibroblast growth factor, type I collagen antibodies in children with severe bronchial asthma.Conclusion. These indicators are a diagnostic marker for a severe bronchial asthma.
Effect of ursodeoxycholic acid on the intestinal microbiota in children with chronic liver disease
Authors: Volynets G. V. , Nikitin A. V. , Skvortsova T. A. , Potapov A. S. , Dudurich V. V. , Danilov L. G.
Published: July 2023

Ursodeoxycholic acid is a secondary bile acid (BA), present in humans at low concentrations, with well-known therapeutic properties, and was originally used to treat cholestatic liver disease. However, there are very few studies on the effect of ursodeoxycholic acid on the composition of the gut microbiota, especially in children with chronic liver diseases.Purpose. To determine differences in the taxonomic diversity of the fecal microbiota in children with chronic liver disease who receive or do not receive ursodeoxycholic acid.Material and methods. A metagenomic analysis of the intestinal microbiota of 24 children with chronic liver diseases (mean age 10.3 ± 4.7 years) was carried out with the identification of the V3–V4 region of the 16S rRNA gene. The group included 18 children with autoimmune liver diseases and 6 children with non-autoimmune liver diseases. 17 children received ursodeoxycholic acid. The comparison group consisted of 7 children who did not receive ursodeoxycholic acid.Results. This study found that fecal samples from patients treated with ursodeoxycholic acid do not differ in the taxonomic diversity of the gut microbiota from samples from patients not treated with ursodeoxycholic acid. A more detailed study to determine the existing taxonomic diversity in samples of patients treated with ursodeoxycholic acid and not treated with ursodeoxycholic acid, using the sPLS-DA method, showed that taxa such as Streptococcus anginosus, Coprococcus eutactus, Desulfovibrio desulfuricans, Angelakisella massiliensis and Gemella haemolysans dominated in patients not treated with ursodeoxycholic acid. And for patients receiving drugs with ursodeoxycholic acid, the dominance of the taxon Anaerostipes hadrus is typical. An analysis of differences in the percentage of intestinal microbiota bacterial species showed that patients receiving ursodeoxycholic acid had a higher count of Anaerostipes hadrus, while in patients not receiving ursodeoxycholic acid preparations, the count of Bacteroides dorei, Akkermansia muciniphila was significantly increased, and the counts of other bacteria were also increased.Conclusion. Studies have shown that ursodeoxycholic acid has a positive effect on the intestinal microbiota in children with chronic liver disease by increasing the number of microorganisms that produce short-chain fatty acids.
Sympathetic denervation — a promising method for treatment of ventricular tachyarrhythmia in children
Authors: Ildarova R. A. , Shkolnikova M. A.
Published: July 2023

Ventricular tachycardia is a rare but potentially life-threatening arrhythmia. Ventricular tachycardia in patients with structural pathology and cardiac channelopathies is associated with the highest risk of sudden cardiac death. The stratification of patients depending on the risk of developing a life-threatening arrhythmia determines the choice of treatment method. Left cardiac sympathetic denervation is a surgical method of treatment aimed at preventing attacks of ventricular tachycardia. The antiarrhythmic effect of sympathetic denervation has been proven in both experimental and clinical studies. Currently, the technique of left cardiac sympathetic denervation consists of a video-assisted sympathectomy by thoracoscopic access, which makes the procedure safe and effective. Left cardiac sympathectomy is used in the treatment of patients with recurrent ventricular tachycardia despite adequate medical therapy. The authors recommend the use of left cardiac sympathectomy in those types of channelopathies, in which stress is the main proven provoking factor of ventricular tachycardia.
Portal hypertension syndrome in children with autosomal recessive polycystic kidney disease with liver cysts and hepatic fibrosis
Authors: Andreeva E. F. , Dyug I. V. , Goryacheva L. G. , Savenkova N. D.
Published: July 2023

Hepatic fibrosis, liver cysts, and portal hypertension are extrarenal manifestations that determine the prognosis of autosomal recessive polycystic kidney disease in children.Purpose. To assess the features of the manifestation and course of liver cystic disease and fibrosis, the development of portal hypertension in the follow-up medical history of children with autosomal recessive polycystic kidney disease.Material and methods. We studied 27 children with autosomal recessive polycystic kidney disease, with two children with a fatal outcome in the neonatal period excluded. 25 children 1–17 years old with autosomal recessive polycystic kidney disease were divided into 2 groups depending on the presence of portal hypertension syndrome. In the long-term follow-up 10 (40%) of 25 children with autosomal recessive polycystic kidney disease had no signs of portal hypertension (group 1), 15 (60%) children had portal hypertension syndrome (group 2). The long-term follow-up, clinical, genealogical, laboratory and instrumental (US, MRI/CT of kidney and abdominal cavity, liver elastography) research methods were used in the study. The diagnosis was confirmed by autopsy for 3 children.Results. There were no cases of changes in the liver and bile ducts characteristic of autosomal recessive polycystic kidney disease by prenatal ultrasound examination. From 27 children with autosomal recessive polycystic kidney disease, in 10 (37%) were diagnosed the liver fibrosis in the long-term follow-up, 22 (81%) had cystic enlargement of intrahepatic veins, of which 15 (68%) had polycystic liver disease, 3 (14%) had Caroli disease. All children with autosomal recessive polycystic kidney disease and portal hypertension syndrome had varicose veins of the esophagus and stomach according to esophagoduodenoscopy, 53% with indications for ligation of phlebectasia, 47% were diagnosed with thrombocytopenia, 67% with anemia, 100% with splenomegaly, 13% with esophageal-gastric bleeding.Conclusion. The differences in the initial manifestations of autosomal recessive polycystic kidney disease were revealed, while no differences in the incidence of hepatic fibrosis and liver cysts were found in 2 compared groups of children.
Epigenetic markers of podocyte repair in children with primary nephrotic syndrome
Authors: Morozov S. L. , Dlin V. V. , Voinova V. Yu. , Smirnova A. V. , Piruzieva O. R.
Published: July 2023

In terms of a glomerular injury research model, idiopathic nephrotic syndrome is the most prominent example. Worldwide, nephrotic syndrome is a socially significant disease and is considered one of the most common glomerulopathies in childhood, leading to the development of chronic kidney disease, and in the case of progression of the disease, to the formation of terminal chronic renal failure. This article presents data from our own study and discusses epigenetic markers of podocyte repair in children with primary nephrotic syndrome. We noted that in patients with steroid-sensitive variants of nephrotic syndrome, the expression of the WT1 (podocyte transcription factor) and NPHS1 (the gene encoding nephrin — a transmembrane protein that is a structural component of the slit diaphragm of the podocyte) genes is significantly higher than in the control group and in children with steroid resistant nephrotic syndrome. The data obtained open up prospects for the development of a personalized approach to the management of children with primary nephrotic syndrome by determining the markers of the staging and/or severity of the pathological process occurring in the glomeruli. Currently, genomic and post-genomic technologies are increasingly being used in clinical practice, which will eventually lead to the development of personalized diagnostic panels based on innovative technologies.
Dynamics of indicators of motor functions on the background of physical rehabilitation in children of early age with epilepsy and motor disorders
Authors: Bukreeva E. A. , Sokolov P. L. , Krapivkin A. I. , Sergeenko E. Yu. , Laysheva O. A.
Published: July 2023

Epilepsy is a chronic brain disease and one of the most common neurological diseases in the world, manifested by sudden seizures due to increased paroxysmal activity of neurons. There are no published studies aimed at assessing the dynamics of motor development in young children suffering from epilepsy with motor disorders.Purpose. The paper aimed at studying the dynamics of motor function indicators in patients with epilepsy on the background of movement disorders during three courses of rehabilitation treatment.Material and methods. We studied 123 young children with epilepsy and motor disorders. Age ranged from 9 months to 24 months. All patients were divided into 3 groups: group 1 patients who received only general massage, group 2: patients who received Vojta therapy, group 3: patients who received massage and Vojta therapy. The duration of remission for clinical seizures in all groups was at least 3 months, remission for video EEG monitoring in all patients was 23 months. Three courses of medical rehabilitation were carried out with an interval of 2 to 5 months for 1015 sessions of 2530 minutes daily. The dynamics of motor development of patients and the effectiveness of medical rehabilitation were assessed using the GMFCS scale, before and after each course of medical rehabilitation.Results. After the first course of rehabilitation, almost no improvement was observed and was unreliable, while after the second course there was a significant positive trend, especially pronounced in group 3. At the same time, the growth of the scale indicators in the period from the end of the first course to the end of the third was almost linear.Conclusion. The data obtained indicate the presence of a certain rigidity of the motor system of such patients, which determines the minimum dynamics after the first course of rehabilitation. Only starting from the second course, we begin to notice a linear improvement in the indicators of motor functions. The preferred duration of the interval between courses, in our opinion, is not less than two and not more than three months.
Cardiovascular system damage in the late-onset Pompe disease
Authors: Leontieva I. V. , Isaeva Yu. S. , Miklashevich I. M. , Thermosesov S. A.
Published: July 2023

The article presents a clinical case of metabolic hypertrophic cardiomyopathy against the background of a late-onset form of Pompe disease, illustrating the difficulties of differential diagnostic search for the cause of the disease. The clinical, laboratory and genetic aspects of the diagnosis of Pompe disease are highlighted. The features of laboratory diagnostics, the difficult path to the correct diagnosis and the appointment of enzyme replacement therapy are discussed. Much attention is paid to the clinical symptoms of the disease — the most significant damage to the cardiovascular system, there is no damage to the musculoskeletal sphere. Clinical picture of late Pompe disease is presented: cardiac rhythm and conduction disorders (ventricular preexcitation syndrome — multiple additional atrioventricular fenestrations), unstable ventricular tachycardia, supraventricular tachycardia, sinus node weakness syndrome. Considered approaches to the prevention of sudden cardiac death the patient underwent surgical treatment: radiofrequency ablation, endocardial implantation of a cardioverter defibrillator. Pathogenetic therapy for Pompe disease has been started.
Information and analytical platform “Digital Phenotype” to identify the relationship between phenotypic and genetic data of patients with hereditary diseases
Authors: Putintsev A. N. , Voinova V. Yu. , Shkolnikova M. A. , Nikolaeva E. A. , Nikolsky D. A. , Razzhivaikin A. Yu. , Gritsevskaya D. Yu. , Kuramagomedova R. G.
Published: July 2023

This paper presents the possibilities of using the Information and Analytical Platform “Digital Phenotype” for a formalized quantitative description of the clinical manifestations of hereditary diseases in children based on deep phenotyping in order to analyze and identify geno-phenotypic correlations, form registers of hereditary diseases and improve the reliability of predicting the course of these diseases. The platform was developed on the basis of the combined use of expert deep phenotyping of a number of rare hereditary disabling diseases manifesting in childhood and modern information technologies for building web applications that allow entering and assessing the severity of phenotypic features, checking the correctness of the input data, forming search queries, exporting chosen digital data. The software design technology is based on the architecture of a relational data model using a cross-platform solution based on the Laravel-AngularJS-mySQL stack. The results of the application of statistical methods for the analysis of geno-phenotypic correlations are presented on the example of identifying the connection of lens dislocation with the presence of a missense mutation in Marfan syndrome. It was shown that in children with mutations at the C-terminus of the MECP2 protein, the level of blood phosphates is lower than in patients with mutations at the N-terminus of the protein.
A child with newly diagnosed kidney disease and his family: determination of early factors of disease progression and features of nephroprotection
Authors: Makovetskaya G. A. , Poretskova G. Yu. , Mazur L. I. , Sedashkina O. A. , Barinov V. N. , Reshetova S. N.
Published: July 2023

Chronic kidney disease and a decrease in its progression is a global health problem. However, the risk factors associated with the primary nosology of glomerular diseases of children have not been sufficiently studied.Purpose. To determine early risk factors for the progression of chronic kidney disease for more effective prevention of chronization of the process, based on the analysis of clinical and anamnestic data, the features of the manifestation of the primary developed glomerular pathology, and taking into account nosological forms.Material and methods. The experience of own clinical observations, retro- and prospective, related to the formation of chronic kidney disease of children with glomerular pathology is summarized. The study was conducted on the basis of the children’s uronephrological center of the Samara Regional Clinical Hospital named after V.D. Seredavin.Results. The universal risk factors are systematized: transferred critical conditions in the perinatal period with the development of acute kidney injury; prenatally established CAKUT syndrome; the presence of a genetic predisposition to kidney diseases, a complex of allergic diseases in the family; the carriage of persistent infections, hemolytic strains of streptococcus, social determinant, environmental conditions, etc. Specific early risk factors for disease progression, features of the onset of kidney pathology and biomarkers of progression that determine early kidney damage have been identified. The features of nephroprotection are formulated: interdisciplinarity with the inclusion of organizational, social components; operational communication with the outpatient link; the use of social networks for educational processes — the patient’s family, training of first-contact doctors.
The First Quarter of 2023 for the Consolidated Budgetsof the Subjects of the Russian Federation: Emerging Trends and New Conditions
Authors: Lykova L. N.
Published: July 2023

At the beginning of the year, the consolidated budgets of the subjects of the Russian Federation were executed in conditions of continued sanctions pressure on the regional economy. Organizational and administrative innovations had a significant impact on the process of budget revenue formation (enactment of payment of taxes using a single tax account, cancellation of income tax payment within consolidated groups of taxpayers, introduction of an accelerated procedure for reimbursement of personal income tax). The growth of regional budget revenues in real terms was provided by federal transfers. Tax revenues grew only nominally. The increase in corporate income tax receipts did not compensate for the reduction in personal income tax receipts. Expenditures of regional budgets grew at a higher rate than revenues, which led to a reduction in the total amount of the positive balance of the consolidated budgets of the subjects of the Russian Federation in most regions. The trend towards an increase in the volume of state and municipal debt has continued with an outstripping growth in the volume of budget loans. There is a substitution of market forms of borrowing for budgetary ones as compensation for the existing inefficient model of distribution of tax powers.
Fiscal and Tax Policy Response to New Challenges and Budget Performance in the First Quarter of 2023
Authors: Bukina I. S.
Published: July 2023

The beginning of 2023 allows us to draw the first results of the Russian economy response to the impact of external and internal shocks in 2022. The structure of the Russian economy remains relatively stable, many catastrophic forecasts have not materialized. However, the sanctions that have come into force and the rapid measures of the anti-crisis policy pose a threat to fiscal stability. The main burden falls on the federal budget, but in the medium term, the depletion of federal reserves will also affect the state of the regional budgets. The paper analyzes the dynamics of indicators of the consolidated budget of the Russian Federation and the budgets of state off-budget funds, as well as separately – the federal budget. In conditions of limited access to data on budget execution, some conclusions are hypotheses and assumptions. In addition, the statistics were distorted by the introduction of the unified tax payment mechanism. The paper distinguishes between the mechanism of the impact of temporary and permanent exogenous shocks. The response of fiscal policy is considered in the context of the division of measures into temporary and structural changes, and appropriate recommendations are given.
Implementation of Social Programs in Conditions of Increasing Labor Precarization: Regional Aspects on the Example of the USA
Authors: Minat V. N.
Published: July 2023

The current complex phenomenon of labor precarization has been extremely actively developed in the United States of America, especially over the past two decades. Undoubtedly, the main reason for the increase in the share of the precariat in the labor market is economic development based on a change in technological patterns, which is characterized in the capitalist economy, on the one hand, by an increase in the role of human capital, and on the other hand, by its overconcentration, including at the intra-country regional level. The emergence and development of a new form of labor relations invariably leads to the need to revise social policy. The regional aspects of the implementation of social programs considered in this paper, which are to some extent capable of mitigating the consequences of the instability of employment and the insecurity of labor relations in the United States for the period 2007–2020, serve as one of the explanations for the intensifying processes of regionalization observed in the country. The result of the study was the identification of two main aspects of the implementation of social programs at the level of subregions and individual states of the country. The first reflects the further regionalization of federal relations in terms of social support for the population, carried out without taking into account the growing precarization of labor in regions with the largest share of the precariat among the employed. The second aspect, which takes into account the structural features of the distribution of funding in the areas of education, health care and social protection of the population, reveals the authorities’ attempt to carry out balanced social programming in the subregions that are potential centers of the “new industrialization” of the American economy. This approach is aimed at preserving and qualitatively developing the human capital of the region by smoothing out the negative consequences of labor precarization.
The Role of Withdrawing Foreign Companies in the Economy of Russian Regions
Authors: Bobrovskiy R. O.
Published: July 2023

The article analyzes the role of foreign companies that announced their withdrawal from Russia after 2022 in the economy of the country as a whole, its industries and regions. The role of withdrawing foreign companies in industry is examined in more detail. The existing list of withdrawing foreign companies forms the basis of the analysis.

Russian legal entities related with these foreign companies were selected. The financial indicators of these legal entities has been aggregated and compared with official statistics. The highest role of withdrawing foreign companies among sectors of the economy in the manufacturing industry and consumer and science-intensive services. Among industrial sectors – is in automotive, paper, tobacco and beverages industries, wood processing and some sub-sectors of mechanical engineering. In the regional context, the highest role of withdrawing foreign companies is in two types of regions: the largest cities and the automotive and wood processing regions. The withdrawal of foreign companies from the largest cities will affect previously on the technological development of industries and the economy as a whole. In the automotive and wood processing regions, the withdrawal of foreign companies is most critical for labor markets, especially if the region’s economy is small and undiversified.
Preferential Territories in the Spatial Development of the Russian Federation
Authors: Odintsova A. V.
Published: July 2023

The spatial development strategy includes many components aimed, on the one hand, at ensuring the balanced development of the regions of the Russian Federation. On the other hand, it is aimed at the formation of preferential mechanisms for territories that particularly require investment and are characterized by negative development trends. The world has accumulated a lot of experience in the functioning of such mechanisms, which allows us to formulate their basic principles and orientation within the framework of the spatial development of a modern state. The article analyzes the main objectives of creating territories with special economic regimes, as well as problems that require attention when coordinating the policy of development of preferential zones, on the one hand, and spatial development in general, on the other. Examples of creation and functioning of preferential territories in different countries of the world are considered. The main stages in the regulation of such territories in Russia are highlighted, as well as the problems that exist on the way of their institutionalization.
Forecasting the Costs for Adapting the Housing Stock to Changing Permafrost Conditions (the Case of Norilsk)
Authors: Badina S. V.
Published: July 2023

The problem of predicting the socio-economic consequences of permafrost degradation due to climate change is an important area of modern scientific research. At the moment, there are no unified approaches and methods for assessing this type of natural risk, respectively, there is no reliable idea of the scale of possible consequences, which in turn is manifested in the poor elaboration of the issue in strategic planning documents for permafrost areas. The city of Norilsk (Krasnoyarsk krai) is an example of an Arctic city in Russia, located in the permafrost zone, where active work has begun on the housing stock renovation, including due to problems associated with the degradation of permafrost under the influence of anthropogenic and climatic factors. An analysis of legal documents related to the socioeconomic development of the city, renovation plans and documents aimed at solving the problem of replacing the deformed housing stock showed that the scale of measures does not fully correspond to the severity of the problem. A comparison of the key characteristics of the Norilsk housing stock, taking into account its current state and plans for transformation, with a long-term forecast of changes in engineering and cryological conditions until 2050, made it possible to estimate the total costs of adaptation, which can reach 1.6 trillion rubles in 2023 prices. In addition, a rating of Russian Arctic municipalities was compiled, based on the ratio of indicators characterizing internal adaptive capabilities to changing geocryological conditions and the amount of expected damage to the buildings and structures. It was found that, in general, the scale of the likely consequences significantly exceeds the available resources, and the most negative situation is already developing in the most depressed areas.
The Southern Vector in the Spatial Development of Post-Soviet Russia: the Main Factors and Manifestations
Authors: Druzhinin A. G. , Kuznetsova O. V.
Published: July 2023

Modern geopolitical and geo-economic processes are accompanied by a radical transformation of the determinants and trends of the spatial organization of Russian society, initiating a revision of the previously established system of regional balances and priorities, sometimes interpreted and discussed as geographically oriented (in the logic of the rhumb approach) vectors of the country’s development. The article is devoted to the southern vector, its dynamics, as well as multidimensional factors and manifestation characteristic of the post-Soviet period. The geopolitical (including ethnopolitical) and foreign economic (transport, logistics and agro-industrial) prerequisites for the growing importance of the territories of its south (South of Russia) for the Russian Federation are identified. The scale is revealed and the specific territorial effects (and problems) of the trend shift of demographic and partly economic potential in favor of the southern regions of the country (in fact, three dozen of the largest southern Russian cities and agglomerations formed on their basis) are evaluated. The steadily continuing importance of the southern vector in the system of federal regulation is emphasized (with a relay race of focused priorities: the Chechen Republic – Krasnodar Krai – the subjects of the Crimea – the new regions of the Russian Federation).
Areas of Assessment and Regional Differences in the Volume and Qualitative Structure of the Housing Market in Russia
Authors: Bychkova S. G. , Dukhon A. B. , Obraztsova O. I. , Epshtein N. D.
Published: July 2023

Residential real estate is one of the most important types of assets, the lack of which becomes impossible the existence and development of the economy. For an entire sector of households, dwellings are not only a source of livelihood, but also determine the cost of living. Moreover, in the 2008 SNA Manual the production of housing services by homeowners for their own consumption is included in the production boundary (as in earlier versions of the UN SNA). This once again emphasizes the importance of studying the housing stock as the most important basis for the real estate market. In addition, the volume, dynamics and structure of the housing stock in various areas of classification is an important factor in the formation of the real estate market, its object-by-object basis, as well as the development of the activities of the subjects of this market. The above considerations determined the relevance of studying the composition and structure of the housing stock of the Russian Federation, including regional differences in the housing stock in the context of a complex of classification features.
Key Performance Indicators for the Implementation of Strategic Plans
Authors: Tchaikovsky L. A.
Published: July 2023

The effective functioning of organizations is directly related to the strategic changes that are carried out using the strategic planning system. The importance of strategic planning today is due, first of all, to a dynamic external environment, a high level of competition, and the need to have a strategic plan to achieve ultimate goals. Strategic planning is especially important in large organizations, as it determines the direction of their development and identifies activities that contribute to the achievement of the organization’s goals. At the same time, the following should be singled out as the most important tasks in choosing the direction of effective development of the organization: the development of a strategic vision and mission of the organization, setting goals and choosing the strategy itself. However, strategic planning should not be confused with planning, as strategic planning is the work on a coherent set of decisions that determine the place of an organization in its industry in order to create competitive advantage and sustainable profits. In turn, the correct alignment of the strategy of organizations will have a positive impact on regional incomes and, as a result, on filling the budget of the region and ensuring employment at its level. In general, strategic planning is high on the priority list of organizations that have faced strong pressure to adapt to the ever-changing environment around them, including factors such as new generations of technology, changing rules, market fluctuations and more agile competitors. As a result, one can imagine such a system of strategic planning in an organization that contributes to the achievement of its goals and provides competitive advantages. The article is devoted to the peculiarities of strategic planning and its role in the effective functioning of the organization. The article also discusses the reasons for the increased attention to the practice of strategic planning only from federal, but also from regional authorities. In addition, the article discusses performance indicators as a convenient tool for assessing and planning the organization’s activities, which form the basis of the strategic planning system.
Çocuk Edebiyatı Eserlerinin Çocuk Hakları Bağlamında İncelenmesi: TRT Çocuk Kitaplık Örneği
Authors: Gök Tülkay Burcu , Sapsağlam Özkan
Published: July 2023

Çocuklar, gelişimsel özellikleri gereği en fazla korunmaya ve desteğe ihtiyaç duyan grupların başında gelmektedir. Çocukların korunmasına yönelik ulusal ve uluslararası düzeyde çeşitli hukuki düzenlemeler bulunmaktadır. Türkiye’nin de taraf olduğu Çocuk Hakları Sözleşmesi bu hukuki düzenlemelerden biridir. Bu araştırmada TRT Çocuk Kitaplık uygulamasında yer alan hikâye kitaplarının Birleşmiş Milletler Çocuk Hakları Sözleşmesi’nde vurgulanan temel çocuk hakları bağlamında incelenmesi amaçlanmıştır. Araştırma, nitel araştırma yaklaşımı ve durum çalışması desenine göre yürütülmüştür. Araştırma kapsamında ‘TRT Çocuk Kitaplık’ uygulamasında yer alan ve farklı yaş gruplarına yönelik olan hikâye kitapları incelenmiştir. Araştırma materyallerinin belirlenmesinde seçkisiz olmayan örnekleme yöntemlerinden amaçlı örnekleme yöntemi ve maksimum çeşitlilik örnekleme tekniği kullanılmıştır. Çalışma materyallerini okul öncesi üç, dört ve beş yaş grubu çocuklarına yönelik farklı yayınevleri tarafından hazırlanmış 15 adet hikâye kitabı oluşturmuştur. Araştırma verileri içerik analizi yöntemiyle analiz edilmiştir. Araştırma sonuçlarına göre, incelenen çocuk kitaplarında çocuk haklarına yönelik sözel ve görsel içeriklerin yer aldığı, hikaye kitaplarında en fazla yaşama hakkına, ikinci sırada gelişme hakkına, üçüncü sırada korunma hakkına ve son olarak da katılma hakkına yer verildiği görülmüştür. İncelenen hikâye kitaplarında çocuk haklarının olumlu kullanımının olumsuz kullanımından daha fazla olduğu görülmüştür.
Valorization and reuse of construction and demolition waste for its transformation into ecological bricks
Authors: Ñañez-Silva Miriam , Sánchez-Cárdenas Luis , Yactayo-Carrión Enrique
Published: July 2023

This research assesses the viability of utilizing construction and demolition waste (CDW) for the production of environmentally-friendly bricks. The methodology employed in this study consists of three main components: An analytical and evaluative investigation of CDW, the selection of appropriate waste materials, and the determination of suitable proportions. The experimental groups were prepared using a volumetric approach, namely Type A (1:6), Type B (1:7), and Type C (1:8), by incorporating CDW, cement, coarse sand, fine sand, crushed stone, confitillo, and polystyrene for the relevant tests. The findings indicate that the optimal composition is achieved with a ratio of 1:5:2 of cement to coarse sand (with 1 part of recycled expanded polystyrene aggregate) and fine sand (with 2 parts of fine sand aggregate) while maintaining a water-to-cement ratio of 1:1. This composition complies with the standards outlined in NTP 399.602:2017, NTP 399.604:2002, and NTP 400.037:2018. In conclusion, the utilization of CDW presents a promising alternative for the construction industry, and effective management practices will facilitate the promotion of a sustainable culture within the sector.
Effect of organizational justice on organization citizenship behavior of female employees in Saudi Arabia
Authors: Alshammari Hammad
Published: July 2023

The aim of this study is to examine the association between organizational justice and organizational citizenship behavior (OCB) among female workers in Saudi Arabia. Organizational justice has been acknowledged as a significant predictor of employee attitudes and behavior; however, its impact on the OCB of female workers in Saudi Arabia remains underexplored. To address this research gap, a cross-sectional survey was conducted among female workers in various organizations in Saudi Arabia. The study assessed organizational justice by considering three dimensions: distributive fairness, procedural fairness, and interactional fairness. Additionally, OCB was measured using a scale adapted from previous research. The collected data were subjected to regression analysis. The study findings indicate a positive relationship between organizational justice and OCB among female workers in Saudi Arabia. Specifically, distributive fairness, procedural fairness, and interactional fairness exerted a significant positive influence on OCB. This research contributes to the existing literature by providing empirical evidence on the impact of organizational justice on OCB among female workers in Saudi Arabia. Furthermore, it extends prior research by investigating the specific dimensions of organizational justice that affect OCB. Nonetheless, there are certain limitations to this study. Firstly, its cross-sectional nature restricts the ability to draw causal inferences. Moreover, the absence of comparisons with other cultural and national contexts represents another limitation. In conclusion, this study holds important implications for organizations in Saudi Arabia and elsewhere that aim to foster OCB among female workers. The findings suggest that enhancing organizational justice can lead to positive work behaviors among female employees. Future research should explore the generalizability of these findings to other contexts and investigate the potential moderating effects of cultural factors.
Store-and-forward teledermatology based on photographs taken with a smartphone by a general practitioner in case of suspicion of melanoma: evaluation of inter- and intra-rater concordance (Preprint)
Authors: Démoulins Edmond , Schmeltz Héloïse , Gaultier Aurélie , Nguyen Jean Michel , Quéreux Gaëlle , Dreno Brigitte , Martin Ludovic , Rat Cédric
Published: July 2023

BACKGROUND

The incidence of melanoma is increasing worldwide. The effectiveness of treatment is associated with diagnostic and therapeutic delays. In this context, teledermatology (TD), especially store-and-forward TD, is a promising technology, as it can accelerate the care process. However, several studies have indicated that the efficiency and reliability of this practice in cases of pigmented skin lesions is not proven and have called for further work.

OBJECTIVE

The main objective of this study was to evaluate inter- and intra-rater management concordance among teledermatologists concerning the appropriate consultation delay when reviewing photographs of suspicious pigmented skin lesions taken with a smartphone by a general practitioner (GP).

METHODS

We first analyzed management concordance among different teledermatologists with experience in TD in 2020. The teledermatologists determined the consultation delay to propose to 110 patients with suspicious pigmented skin lesions viewed online based on 241 photographs taken by GPs in a real-life context. The practitioners had to decide among 4 possibilities for care management: 1. urgent need for consultation (15 days), 2. non-urgent need for consultation, 3. no need for consultation ("simple letter to the attending physician"), and 4. impossible to assess: request for additional information or photographs from the GP. "Major" discordance was defined as follows: one teledermatologist decided that the patient needed a consultation within 15 days, while another teledermatologist decided that it was not necessary to see the patient. We performed the same analysis two years after to evaluate the intra-rater concordance.

RESULTS

This study revealed poor agreement among dermatologists when they assessed photographs taken by a GP using a smartphone. The interrater agreement was poor regardless of the analytical modality used. The 2-to-2 interdermatologist management concordance revealed a low Cohen's kappa (between 0.11 and 0.43). Overall agreement was low (Fleiss’ kappa 0.24 in 2020 et 0.27 in 2022). We observed major discordance regarding care management for 38% of the patients in 2020 and 25% of the patients in 2022. Those results of interrater agreement were confirmed by the second analysis in 2022. The intra-rater concordance was poor also with low Cohen's kappa indices (between 0.37 and 0.46).

CONCLUSIONS

The poor inter- and intra-rater agreement calls into question the relevance of the store and forward dermatology, without the use of dermoscopy, for suspicious pigmented lesions. This study is in line with recent studies calling for postponement of the development of store-and-forward TD for the management of suspicious pigmented skin lesions until additional studies have been carried out.
Patients, Doctors, and Chatbots (Preprint)
Authors: Erren Thomas C
Published: July 2023

UNSTRUCTURED

Medical advice is key to the relationship between doctor and patient. The question I will address is “how may chatbots affect the interaction between patients and doctors in regards to medical advice?” I describe what lies ahead when using chatbots and identify questions galore for the daily work of doctors. I conclude with a gloomy outlook, expectations for the urgently needed ethical discourse, and a hope in relation to humans and machines.
Authors’ Response to the Validity of Cortisol and Galvanic Skin Responses for Measuring Student Stress During Training (Preprint)
Authors: Toohey Shannon , Wray Alisa , Hunter John , Saadat Soheil , Boysen-Osborn Megan , Smart Jonathan , Wiechmann Warren , Pressman Sarah D
Published: July 2023

UNSTRUCTURED

 

INTERNATIONAL REGISTERED REPORT

RR2-36447
Teachers’ Efforts and Barriers to Implementing Empirically-Based Practices in Addressing Disability Stigma
Authors: Oates Rachel L.
Published: July 2023

Stigmatization of students with disabilities leads to adverse long-term effects and teachers experience challenges implementing empirically-based practices to address this stigma. This study explored teachers’ efforts to address stigma in the classroom and barriers to implementing such efforts. The Disability Stigma Perspectives and Practice (DSPP) survey was completed electronically by 330 teachers from a school district. Descriptive analysis revealed that 90 percent of teachers reported attempts to address stigma, with social contact based practices being most frequently endorsed. Additionally, descriptive analysis indicated that the most commonly reported barriers to implementing empirically-based practices to address stigma included constraints of time, materials, class size, and feeling overwhelmed. The implications of these findings for school psychologists, administrators, and educational institutions in providing the appropriate support for teachers to successfully implement strategies to reduce stigma are discussed.
A Literature Review on Japanese Tragic Female Images—In Case of Memories of Matsuko
Authors: Qian Yishuang
Published: July 2023

Memories of Matsuko is a masterpiece by the popular modern Japanese author Muneki Yamada, with a circulation of 1.2 million copies including the pocket edition book. The work portrays a tragic woman, Matsuko Kawajiri, who despites all her hardships, still laughs at life and courageously pursues love. However, such an active woman has come to a tragic end. Thus, the literary figure of Matsuko Kawajiri embodies the tragic nature of modern Japanese women from multiple perspectives, including the family and the workplace, and can be said to have representative characteristics.
The Impact of Cloud Computing in the field of Finance: A Comprehensive Analysis
Authors: Patel Namira , Bhattacharjee Itika , Jagli Dr. Dhanamma
Published: July 2023

Abstract: The advent of cloud computing has revolutionized the landscape of various industries, and the finance sector is no exception. This research paper explores the impact of cloud computing in finance, focusing on its potential benefits, challenges, and implications for financial institutions. The paper begins by providing an overview of cloud computing, highlighting its fundamental characteristics such as on-demand self-service, broad network access, resource pooling, rapid elasticity, and measured service. It then delves into the specific applications of cloud computing in the finance industry, including infrastructure-as-a-service (IaaS), platform-as-a-service (PaaS), and software-as-a-service (SaaS). The benefits of adopting cloud computing in finance are examined, such as cost reduction, scalability, flexibility, enhanced collaboration, and improved accessibility. Moreover, the research paper investigates the challenges associated with cloud adoption in the finance sector. Security and privacy concerns, regulatory compliance, data sovereignty, vendor lock-in, and integration complexities are among the key issues discussed. The paper explores strategies and best practices for mitigating these challenges, including encryption, authentication protocols, compliance frameworks, and hybrid cloud models. Furthermore, the implications of cloud computing in finance are analyzed, focusing on its impact on financial operations, risk management, data analytics, customer experience, and innovation. The research paper also explores the evolving role of financial institutions and the changing skill requirements for professionals in a cloud-enabled environment. Finally, the paper concludes by summarizing the findings and emphasizing the transformative potential of cloud computing in the finance industry. It highlights the need for financial institutions to carefully evaluate the risks and benefits of cloud adoption, develop robust security measures, and adapt their business models to fully leverage the advantages offered by cloud computing.
Water Birds of Subhas Sarobar and their Diversity Assessment: Capacity Building in Research Aptitude of Students of Rammohan College, Kolkata
Authors: Bawali Sriparna , Banerjee Shirsa , Barman Lopamudra , Singh Kavita , Ghosh Tania , Guin Shinjani , Khatun Morjina , Biswas Aditi
Published: July 2023

Abstract: Birds perform numerous important ecological services and are sensitive indicators of biological diversity and environmental trends. Around the world, birds may be found in nearly every climate and at nearly every height. They are a natural method of eradicating pests from farms, gardens, and aquatic habitats. Numerous bird species react to even little alterations in the structure and make-up of their habitats, making them useful as environmental change indicators. The Subhas Sarobar is a sizable body of water close to the East Calcutta Wetland (220 43'6" N, 880 24'3" E), which is home to several water bird. The West Bengal Pollution Control Board, a division of the West Bengal Government, first reported the presence of an avifauna in this environment in the year 2000. The current authors looked into the avifauna's actual state in Subhas Sarobar (2019–2020). In contrast to the 7 species reported in 2000, 13 species of water birds belonging to 6 Orders and 6 Families were discovered during a field survey. The Shannon-Wiener index has been used to gauge their diversity. They have been discovered to be in homeostasis, despite anthropological disturbance.