bluuebunny/crossref_metadata_2025 huggingface dataset:
FEATURES OF NATURAL GAS DEMETHANIZATION PROCESS
Authors: Kazakova Anastasia I. , Khafizova Svetlana R.
Published: November 2023

Today, a significant part of the raw materials used in industry consists of natural gas. Thus, an important and urgent task for the further development of the industry is the development of more advanced processes aimed at natural gas treatment and processing of. Low temperature processes in gas processing are widespread due to the increasing demand for individual hydrocarbons and the growing demand for liquefied gases. Low temperature distillation remains the most important method for separating gas mixtures, especially when high throughput is required. The demethanization process is an industrially important example of such a process, which involves the interaction of separation, cooling and heat recovery systems.This article discusses a number of basic methods for low-temperature gas separation, such as condensation, rectification, absorption and separation, as well as the features of their application. Low-temperature separation is carried out in two stages in column-type apparatuses, the first of which demethanization is carried out with methane and C2+ fractions release. An overview of the demethanization process currently used for natural gas refining is given, and the key features of the demethanizer operation are described. The technological design of the process of low-temperature distillation, the design features of the installations are considered, a typical scheme of the demethanization process is given. Various technological schemes of demethanization proposed in patents are analyzed. A comparative analysis of the use of tray and packed contact devices and criteria for choosing a mass transfer column apparatus are given. The demethanization column arrangement is shown, the internal devices of the column, the feed input system, as well as the method of supplying heat to the demethanizer are described.
INJECTION MOLDING TECHNIQUE: CORRECTING THE DREADED "BLACK TRIANGLE". v2
Authors: Ferrando Cascales DDS,PhD. Álvaro
Published: November 2023

The treatment of open gingival embrasures area, also known as black triangles, has always been a frequent reason for consultation in daily clinical practice. It is undoubtedly one of the most important unaesthetic sequelae of periodontal disease Cunliffe et al. evaluated in 2009 the perception of 80 randomly selected patients in terms of the number of visible black triangles and their severity. They concluded that the presence of black triangles was the third most unpleasant aesthetic problem after caries and dark crown margins The technique we are going to describe is known as "injection molding". Based on the use of a patented matrix system (Bioclear. Washington. USA) by Dr. David Clark, which is combined with a refined technique that simultaneously uses flowable composite and conventional heated composite (nanofiller/microhybrid). The clinical procedure consists of 10 steps that must be performed in order.
Immobilizing cells for live imaging v1
Authors: Essock-Burns Tara , Matus David
Published: November 2023

This protocol covers the sample preparation for high-resolution confocal microscopy to visualize algal cells and their organelles (chloroplasts and mitochondria) by immobilizing them in agarose. The sample preparation includes preparing low-gelling agarose, staining the cells, and preparing the slides with live, but immobilized, algal cells.
protocols.io academic and non-profit contract v2
Authors: team protocols.io
Published: November 2023

Template Contract This contract is hereby made between the UNIVERSITY/ORGANIZATION (Univ) and ZappyLab, Inc. (DBA “protocols.io”). DATE:December 13, 2021START DATE:December 27, 2021END DATE:December 26, 2022DESCRIPTION OF SERVICES:protocols.io will collaborate with Univ on provision of scientific research support and tools to Univ researchers and staff.COST:The annual cost is USD $10,000 for all workspace protocols.io accounts for Univ-affiliated students, faculty, researchers and staff. Deliverables are listed below.
Stent-ception: implementation of soft double-J stents in the ureteric Memokath-051TM in bilateral ureteric stricture post radiotherapy for advanced prostate cancer
Authors: Mohd Isa M. F. , Mohamed Ashraf M. D. , Yusof M. R. , Faiz N. G. , Merican S.R. H.I.
Published: November 2023

Narrowing of ureter can be due to malignant or benign causes. Temporary double-J (DJ) stents, various metallic stent designs, or definitive corrective surgery can be the options management for ureteric stricture. As an alternative from DJ stents, Memokath-051TM (MMK-051TM) can be inserted in strictured ureters post radiotherapy for advanced prostate cancer patients. We present a case of an advanced prostate cancer which bilateral DJ Stents placed within MMK-051TM. A 76-year-old man with underlying hormone sensitive advanced prostate cancer completed radiotherapy. Post radiotherapy he developed bilateral ureteric strictures  and bilateral DJ stents  inserted.  He had to underwent multiple change of stents due to blockage. Patient had MMK-051TM inserted, however complicated with blockage due to encrustation. Improvisation method done by putting the bilateral DJ stents within the MMK-051TM. Patient had no more blockage of MMK-051TM after the placement of DJ stents within it. However, patient succumbed to death a year after the last procedure. Our case report highlighted encrustation of metallic ureteric stents and a novel approach to overcome this problem. Introduction  of additional DJ stents  not only reduced the incidence of MMK-051TM blockage but also improved the quality of life of the patient.
Metanephric adenoma of the kidney: clinical case and literature review
Authors: Grebenkin E. V. , Pshikhachev A. M. , Osmolovskiy B. E. , Epishkina A. A. , Kozhevnikova E. Yu. , Sorokin N. I. , Kamalov A. A.
Published: November 2023

Metanephric adenoma is a rare benign kidney tumor with a favorable prognosis. These neoplasms are often interpreted as malignant at the preoperative stage, since they do not have specific characteristics showing during instrumental imaging methods, which leads to excessive surgical treatment in the context of nephrectomy volume. Therefore, histological verification is the gold standard for diagnosis. The morphological features of metanephric adenoma are in many ways similar to such kidney tumors as papillary renal cell carcinoma and nephroblastoma (Wilms’ tumor), so sometimes additional research methods are required, including immunohistochemical and molecular genetic ones. In this article, we report a rare clinical case of metanephric adenoma in a forty-seven-year-old woman. The results of clinical and instrumental exams, as well as morphological features of the tumor are presented. A review  of the literature on the clinical, morphological, and molecular aspects of this tumor is also presented.
The practical significance of using Canephron N medication for radiation cystitis prevention in patients undergoing radiation/chemoradiation therapy
Authors: Korotkikh N. V. , Moshurov I. P. , Andreeva O. V. , Zagryadskaya D. O. , Andreev V. A. , Kulikova I. N. , Kamenev D. Yu.
Published: November 2023

Background. With increasing life expectancy in cervical cancer patients, new medical and social problems associated with radiation therapy become apparent.  The combination of radiation therapy and chemotherapy is an important therapeutic component in treatment of malignant neoplasms of the genital area in women, but the frequency and severity of side effects has been increasing. Radiation complications occur in 20–50 % of patients.  In 5 % of patients, they can represent a severe and potentially life-threatening condition. Prevention of negative effects on the genitourinary system in cervical cancer patients receiving radiation therapy on the pelvis is a matter of importance.

Aim. To evaluate the clinical efficacy of a phytotherapeutic  preparation Canephron  N containing centaury, lovage root, rosemary leaves in the prevention of radiation cystitis during chemoradiotherapy in patients with advanced cervical cancer.

Materials and methods. The study included 60 patients with locally advanced cervical cancer receiving radical chemoradiotherapy. The patients were divided into 2 groups: treatment  group consisting of patients receiving phytotherapeutic preparation Canephron N for prevention of radiation complications, and control group consisting of patients not receiving symptomatic treatment.  The treatment results were evaluated using questionnaires, clinical, laboratory and instrumental studies. The obtained data were compared with the results of treatment of the control group which were not prescribed a medication for prevention of urological complications.

Results and conclusion. The use of Canephron N in accompanying therapy had significantly decreased the risk and incidence of radiation cystitis.
Acute kidney injury and its predictors in surgery of malignant kidney tumors
Authors: Pozdnyakov K. V. , Rakul S. A. , Eloev R. A. , Lukinov K. A.
Published: November 2023

Aim. To analyze our own results of the course of early postoperative period in patients who underwent surgical treatment of kidney tumors: partial nephrectomy (PN) and radical nephrectomy (RN) and to identify risk factors for the development of acute kidney injury (AKI).

Materials and methods. The study included 399 patients, of which 276 patients (69.17 %) underwent PN, 123 (30.83 %) underwent RN. According  to the clinical stage of the disease, patients in the PN and RN groups were distributed as follows: cT1a – 160 (91.95 %) and 14 (8.05 %), cT1b – 99 (61.11 %) and 63 (38.89 %) and cT2a – 17 (26.98 %) and 46 (73.02 %), respectively. Operations were performed with open (1.0 %), laparoscopic (39.35 %) and robot-assisted (59.65 %) accesses. AKI was evaluated by the changes in serum creatinine and glomerular filtration rate before surgery and 1–3 days after in accordance with KDIGO criteria.

Results. The overall incidence of AKI after surgical treatment  for kidney cancer at stages cT1a–cT2a was 27.57 %. The incidence of AKI after RN was 65.04 %, after PN – 11.23 %. At stages cT1a, cT1b, cT2a, after nephron-sparing surgery and radical treatment, this indicator was 9.37; 11.11; 29.41 % and 71.43; 63.49; 65.22 %, respectively. For warm ischemia time below 15 and 20 minutes, AKI incidence did not exceed 8.3 and 13.2 %, respectively. For warm ischemia time >30 min, a dramatic increase in AKI incidence was observed.

Conclusion. To preserve kidney function, PN is the operation of choice in surgical treatment of kidney tumors at stages cT1–cT2a. After RN, AKI development was observed 6 times more often than after PN. The following statistically significant predictors of AKI after PN were identified: presence of initial chronic kidney disease in patients, tumor size, operative time above 190 minutes, type of kidney ischemia used, and warm ischemia time above 25 minutes.
Examining The Relationship Between Children's Dietary Patterns and The Development of Dental Problems
Authors: Srinivas Murthy ST  , Amit Kumar  , Bhumika Kamal Badiyani
Published: November 2023

Background: This cross-sectional study explores the relationship between children's dietary patterns and the development of dental problems in a sample of 200 participants aged 6 to 12 years. Recognizing the critical role of nutrition in pediatric oral health, the study aims to identify associations between dietary habits, nutrient intake, and prevalent dental issues. Methods: Dietary patterns were assessed using a Food Frequency Questionnaire (FFQ), and nutrient intake was analyzed. Clinical examinations by trained dental professionals evaluated dental problems, including caries, enamel erosion, and malocclusions. Statistical analyses, including logistic regression, were employed to examine associations between dietary patterns and dental outcomes. Results: Demographic characteristics indicated a balanced sample with equal gender distribution and representation across age groups. Analysis of dietary patterns revealed mean values within recommended ranges for caloric intake, protein, carbohydrates, fat, and calcium. Significant associations were found between high sugar consumption and dental caries, low calcium intake and enamel erosion, and irregular snacking habits and malocclusions Conclusion: This study underscores the importance of understanding the intricate relationship between children's dietary patterns and dental health. The identified associations provide insights for targeted interventions aimed at reducing sugar consumption, promoting adequate calcium intake, and addressing irregular snacking habits to enhance pediatric oral health.
Bloch–Sulzberger syndrome (Incontinentia pigmenti)
Authors: Shchava Svetlana N. , Shishkina Marina A.
Published: November 2023

Bloch–Sulzberger syndrome or Incontinentia pigmenti is a genetic disease that causes skin pathology in the first days of a child's life and is suspected of identifying the disease.
The article presents the characteristic signs of this syndrome and the pronounced manifestations of the disease. A presumptive case of a girl born in a family without a burdened anamnesis: the first manifestations of the disease appeared on the fifth day of life, were represented by linearly arranged vesicular-bullous rashes on an erythematous background and were regarded as a skin infection. Due to the ineffectiveness of the therapy, the patient was consulted by a dermatovenerologist, geneticist, neurologist. The child was consulted again at 5.5 years old: the article presents the data of a medical and genetic study and distant clinical signs of this syndrome in the form of hyperpigmented spots in combination with foci of atrophy, alopecia and dental anomalies in the sixth year of life.
Thus, the clinical signs of Bloch–Sulzberger syndrome made it possible to diagnose the disease at the newborn stage, which, in turn, helped to avoid unjustified prescribing of various systemic medications, to develop an individual treatment plan for the child and, as a result, contributed to the prevention of the development of complications of the disease and to improve the patient's quality of life.
Antibiotic therapy of acne and antibiotic resistance: State of the art
Authors: Smirnova Irina O. , Khazhomiya Kristina D. , Petunova Yanina G. , Shin Natalia V. , Smirnova Olga N. , Ptashnikova Polina D.
Published: November 2023

Acne is one of the most common dermatoses, with 117 million people diagnosed with the disease each year. Acne has a complex multifactorial genesis, including genetic predisposition and the influence of exposome factors. The direct mechanisms of the disease are associated with increased sensitivity of sebaceous glands to androgens, sebum hyperproduction, impaired keratinization at the mouth of hair follicles, and inflammation, in the induction of which Propionobacterium acnes is involved.
The treatment of acne is complex, and one of its strategies is to regulate the number and activity of P. acnes through the use of antibacterial therapy. Antibacterial drugs have been used in the treatment of acne since the 1950s. They are included in a number of clinical guidelines and expert consensus documents for the treatment of the disease. However, the use of antibacterial drugs is limited by the formation of antibiotic resistance. Antibacterial drugs resistance in acne was first noted in the 1970s and was labeled as a global problem in the 2000s. The rapid increase in antibiotic resistance has prompted the development of strategies to prevent it and limit the use of antibacterial drugs in acne.
This review presents information on the efficacy and place of antibacterial drugs in the treatment of acne, the epidemiology and mechanisms of antibiotic resistance, and strategies to overcome it. The authors consider and substantiate the effectiveness of a fixed combination of adapalene 0.1% and benzoyl peroxide 2.5%, based on the effect on the key links in the pathogenesis of acne, synergism of action and suppression of even antibiotic-resistant strains of P. acnes.
Urinary incontinence in obese women
Authors: Soluyanov Mikhail Yu. , Rakitin Fedor A. , Gvozdev Mikhail Yu.
Published: November 2023

In recent decades, obesity has assumed the features of a pandemic. Leading to the development of many complications, obesity also contributes to the development of urinary incontinence. The review presents current data on the etiology, pathophysiology and approaches to the treatment of stress urinary incontinence in obese patients. There are a large number of publications by foreign authors on the problem of urinary incontinence in patients with obesity. The results of the studies allow us to say with confidence about the direct relationship between an increase in body mass index and the risk of developing urinary incontinence. Long-term results of surgical treatment of urinary incontinence in obese patients require reflection and further observation. It is noteworthy that this problem is practically not reflected in the works of domestic authors. It is relevant to conduct domestic clinical studies on the problems of urinary incontinence in patients with obesity.
Immunohistochemical diagnosis of tumor-associated macrophages in patients with muscle-invasive bladder cancer after radical cystectomy
Authors: Pavlov Valentin N. , Urmantsev Marat F. , Bakeev Marat R.
Published: November 2023

BACKGROUND: Bladder cancer is a serious problem of oncourology. The gold standard of treatment for muscle-invasive bladder cancer is radical cystectomy with previous neoadjuvant chemotherapy. Unfortunately, the effectiveness of radical treatments is severely limited in the long term. For this reason, research in the field of predicting survival can significantly improve long-term oncological results. The determination of the levels of macrophages associated with the tumor appears promising.
AIM: to determine the effect of the expression levels of macrophages associated with a tumor on survival rates in patients diagnosed with muscle-invasive bladder cancer after radical cystectomy.
MATERIALS AND METHODS: the study was conducted on the basis of the Clinic of the Bashkir State Medical University in the period from 01.05.2021 to 01.07.2023. The study involved 66 patients with an established diagnosis of muscle-invasive bladder cancer. After surgical treatment, histological and immunohistochemical studies were performed to determine CD68 and CD163 levels. After 24 months, a survival analysis was performed to determine the levels of general, tumor-specific and relapse-free survival and the construction of Kaplan–Mayer graphs.
RESULTS: According to the results of the analysis, there was a significant decrease in survival in groups with high CD68 and CD163 expression rates (p 0.05). In the study groups, there was a significantly significant correlation between high levels of CD68 and CD163 (p 0.05).
CONCLUSIONS: CD68 and CD163 can act as independent markers of predicted survival in patients with muscle-invasive bladder cancer after radical cystectomy.
No-scalpel vasectomy — a new approach to male surgical contraception: a single center experience
Authors: Ryzhkov Aleksei I. , Sokolova Svetlana Yu. , Shormanov Igor S.
Published: November 2023

BACKGROUND: No-scalpel vasectomy is a modern approach to performing vasectomy, in which access to the vas deferens is achieved through a puncture of the scrotum.
AIM: To analyze of own experience in the use of no-scalpel vasectomy.
MATERIALS AND METHODS: During the period from April 2017 to December 2022, 32 men underwent non-scalpel vasectomy at the Mother and Child Clinic Yaroslavl. Three operations were performed under intravenous anesthesia, 29 under local anesthesia. Occlusion of the vas deferens was achieved by excision of the fragment, coagulation of the lumen, ligation of the ends of the duct and fascial interposition.
RESULTS: The average age of the patients was 39 years (range 35 to 62 years). All patients were married. The mean number of children in patients undergoing vasectomy was 2.3 ± 0.4. In all cases, the reason for performing a vasectomy was cited by patients as dissatisfaction with other methods of contraception. The average operation time was 19.0 ± 4.0 minutes. The average size of the scrotal skin puncture was 9.3 ± 1.3 mm (range 7 to 11 mm). The severity of pain during surgery, as assessed on a visual analogue scale (VAS), varied from 1 to 3 points, with an average of 2.3 ± 0.5 points. In the postoperative period, one patient developed acute epididymitis (3.1%), and one patient (3.1%) developed a small hematoma (up to 1 cm) in the area of the surgical wound. A week after surgery, 15 patients (46.8%) reported the presence of pain with a visual analogue scale score of 1 to 3 points, with an average of 2.2 ± 0.7 points. One month after the operation, no pain was noted in any patient. The results of the study of the ejaculate 3 months after the operation showed the presence of azoospermia in 27 (84.4%) patients and the presence of single immobile spermatozoa (less than 100,000/ml) in 5 (15.6%) patients, which allowed us to state 100% occlusive effectiveness of vasectomy.
CONCLUSIONS: No-scalpel vasectomy is a less traumatic and safe method of male surgical contraception. The operation under local anesthesia is associated with minimal discomfort for the patient. Maximum success rates can be achieved using the technique of vas deferens occlusion through excision of the fragment, coagulation of the lumen, ligation of the ends of the duct, and fascial interposition.
Eavesdropping and Jamming via Pilot Attacks in 5G Massive MIMO
Authors: Angoue Avele Marc Bernice , Perez-Adán Darian , Pereira-Ruisánchez Dariel
Published: November 2023

In this work, we investigate pilot attacks for 5G single-cell multi-user massive multiple input multiple-output (MaMIMO) systems with a single-antenna active eavesdropper and a single-antenna jammer operating in time-division duplex (TDD) schemes. Firstly, we describe the attacks when the base station (BS) estimates the channel state information (CSI) based on the uplink pilot transmissions. Finally, we propose a reinforcement learning (RL)-based frame work for maximizing the system sum rate that proved robust to the eavesdropping and jamming attacks.
Ten-year outcomes of surgical treatment of ischemic mitral regurgitation-a retrospective study
Authors: Vajpeyi Anshuman , Panicker Varghese T.
Published: November 2023

Background: Mitral regurgitation (MR) is a prevalent form of valvular heart disease, affecting millions of people worldwide. Primary MR occurs due to mitral valve dysfunction, while secondary MR is caused by left ventricle remodelling. The study aimed to investigate the long-term outcomes of patients with IMR after undergoing coronary surgeries, including coronary artery bypass graft (CABG) with or without mitral valve repair or replacement.
Methods: Retrospective, observational study design was planned. Pre-operative and postoperative data were collected from 68 patients with ischemic MR who underwent coronary artery bypass surgery, with or without Mitral valve replacement or mitral valve repair. (That is CABG only/CABG+MVR/CABG+MVr) in the year between 2001 and 2010. Patients followed up at 3 months, 1 year, and 10 years after the procedure.
Results: Significant improvements in New York heart association (NYHA) functional class and MR status were observed for all three surgical groups, namely, a) CABG surgery, b) coronary artery bypass graft surgery with mitral valve replacement (CABG+MVR), and c) coronary artery bypass graft surgery with mitral valve repair (CABG+MVr). After 10 years, redo surgery rates were minimal for CABG only and CABG+MVR groups of patients, while CABG+MVr required 20% redo surgery. Postoperative complications, such as left ventricle failure, were seen in the immediate postoperative period, leading to the death of those patients 3 months following the surgery. After 3 months, complications decreased over time for all groups.
Conclusions: Surgical interventions effectively improved functional outcomes and reduced MR severity in patients with ischemic MR. Redo surgery rates were low for most patients, indicating the success of the initial procedures.
Alternative therapy of menopausal vegetative disorders in women taking the metabolic status into account
Authors: Taran О.А. , Konkov D.H. , Bulavenko O.V. , Lobastova T.V. , Malinina O.B. , Homon N.M. , Pyvniuk I.R.
Published: November 2023

Research objectives: to study the clinical effectiveness of alternative complex therapy of vegetative syndrome in menopausal patients using L-arginine and xylitol drugs. Materials and methods. The clinical prospective study included 50 patients in the early postmenopausal period with natural menopause, neurovegetative and psychoemotional manifestations of the climacteric syndrome. According to the Life extension strategy, patients received intravenous L-arginine (Tivortin drug) and xylitol solution with electrolytes (Xylat drug) for endothelial protection and correction of insulin resistance in order to treat climacteric syndrome. Modified Kupperman menopausal index, serum triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein levels were determined in all women. Examinations were performed before the start of therapy and 3 months after the end of treatment.Results. The Life extension therapeutic strategy as an alternative comprehensive therapy of the vegetative syndrome in menopausal patients contributed to a reliable reduction of the manifestations of the climacteric syndrome. The advantage of combined therapy involving L-arginine and xylitol was manifested in a significant decrease in diastolic blood pressure (p = 0.043); reduction of the Kupperman index (p = 0.002) and the average score of vasomotor symptoms (p = 0.02). There was also a significant decrease in the serum level of insulin (p = 0.00007), HOMA index (p = 0.01), low-density lipoproteins (p = 0.04), and triglycerides (p = 0.03). The selected therapy was well tolerated during the observation period.Conclusions. The combined therapy involving L-arginine and xylitol in the early postmenopausal period with neurovegetative and psychoemotional manifestations of the climacteric syndrome had a pronounced clinical effect, which consisted in a significant reduction of vegetative disorders and stabilization of carbohydrate and lipid metabolism. The given therapeutic strategy can be considered as an alternative therapy in patients with climacteric disorders when phytotherapy is ineffective and when there are contraindications or limitations to menopausal hormone therapy. The results of this study showed the safety of the Life extension strategy.
Kavramsal, Tarihsel ve Pratik Açıdan Dinden Dönme ve İnanç Özgürlüğü
Authors: SANCAR Faruk , KORKMAZGÖZ Rıza
Published: November 2023

Aydınlanma Çağı sonrasında dünyada yaşanan hızlı değişim, bilimsel ve teknolojik anlamda devrimsel yenilikler meydana getirdiği gibi düşünce bağlamında da önemli dönüşümlerin kapısını aralamıştır. Özellikle Fransız ihtilalinin oluşturduğu rüzgarla birlikte daha önceden tedavülde olan eşitlik, kardeşlik, adalet gibi bazı kavramlar çok daha fazla gündeme gelmiştir. Bu süreçte ön plana çıkan kavramlardan birisi de özgürlüktür. Kavram, felsefede determinizm fikrinin karşısında özgür irade anlayışı olarak; siyasette baskıcı yönetimlere karşı bağımsızlık şeklinde kendini göstermiştir. Konu, müstakil bir başlık olarak ele alındığı günden itibaren, -basın, düşünce, ifade, din ve vicdan hürriyeti olmak üzere- farklı tür ve boyutlarıyla dikkati çekmiştir. Batı dünyasının son iki asırlık düşünsel serüveninin de aslında bu kavramlar etrafında şekillendiğini görüyoruz. İlk başta dinî ve dünyevî otoritelere başkaldırı şekilde kendisini gösteren özgürlükçü tavır, daha sonraları kendisini bütün ahlakî ve toplumsal normlardan bağımsız gören uç noktalara kadar savrulmuştur. Bu tartışmalar ister istemez ilahiyat alanına da yansımış ve insanın iradesinin tanrının iradesi karşındaki konumu, kader ve kötülük problemi gibi başlıklar, çağdaş iddia ve itirazlara göre yeniden ele alınmıştır. Batı dünyasında ortaya çıkan ateist eğilimler, bütün dinlerin insanı yeryüzünde aktif bir özne imkanından mahrum bıraktığını ve bütün eylemlerinin bilindiğine ve belirlendiğine inanan bir insanın gerçek anlamda özgür olamayacağını iddia etmişlerdir. Bu nokta aslında çağdaş ateizmin teizme yönelttiği birkaç önemli konu başlığından biridir. Çok geçmeden bu tartışmalar İslam dünyasına da taşınmış ve benzer argümanlarla konu ele alınmaya devam etmiştir. Bu iddiaların her biri özünde, İslam’ın insan tasavvurunun bireye herhangi bir özgürlük alanı bırakmadığı varsayımına dayanır. Problemin başta kader ve teodise gibi farklı boyutları olmakla birlikte dikkati çeken yönlerinden birisi de insanın özgür iradesiyle İslâm’a girme hakkı olduğu gibi inkâr hakkının da bulunup bulunmadığı sorusudur. Bu sorunun cevaplanması önemlidir. Çünkü İslâm tarihinin erken dönemine ait bazı uygulamalar ile İslâm hukukunda yerleşik bir içtihatmış gibi kabul gören dinden dönenlerin belli şartlara göre öldürülmesi gerektiğine dair kabuller, İslâm karşıtı düşünce ve ideolojilere önemli fırsatlar sunmuştur. Bu makale bir yandan klasik birikimde konunun nasıl ele alındığını göstermeye çalışırken bir yandan da günümüzdeki din değiştirme olgusuna nasıl yaklaşılması gerektiğine dair çözüm önerileri sunmaya çalışacaktır. Ayrıca çalışmada fıkıh literatüründe meselenin daha ziyade kamu güvenliği bağlamında ele alındığı, dolayısıyla da günümüzdeki din değiştirme veya dinden dönme hadiselerinin klasik dönemdeki tartışmalarla tam olarak örtüşmediği ortaya konulacaktır.
OPERATIONAL LEVERAGE IN PROFIT MANAGEMENT OF A PHARMACY ENTERPRISE
Authors: Mazur O. Ye.
Published: November 2023

In Ukraine, against the backdrop of a reduction in overall production volumes and demand, the pharmaceutical industry has a high need for profit planning and forecasting, and therefore the study of indicators that affect it. The article is devoted to the possibilities of planning the profit of a pharmacy enterprise based on the indicator of operating leverage. In the Ukrainian scientific literature, operational leverage in the management of the profitability of enterprises is studied quite poorly, there are no studies on the pharmaceutical industry at all.
The purpose of the article is to substantiate the method of profit management of a pharmacy enterprise using the indicator of operating leverage; development of an effective toolkit for forecasting the profitability of a pharmacy with any breadth of assortment; determination of factors for choosing the method of calculating operating leverage for pharmacy institutions; providing recommendations to pharmacy institutions on monitoring and regulating the level of operating leverage depending on the circumstances of the economic environment.
For a pharmacy institution, it is proposed to calculate the level of operating leverage in different ways – depending on the available data, the features of the assortment and the goals of the analysis. The article presents methodical approaches for calculating leverage both for the pharmacy as a whole and for individual assortment groups or product positions. The formulas for forecasting the profitability of the pharmacy as a whole and the profitability of specific groups of medicines are given. The methodology is demonstrated on a conditional example. Different ranges of leverage values are considered.
The factors that determine the amount of operating leverage for pharmacy institutions are described. The need to take into account industry specifics and leverage management capabilities is emphasized. Recommendations are given to pharmacy institutions on monitoring and regulating the level of operating leverage depending on the circumstances of the economic environment, the life cycle of the pharmacy and the characteristics of the cost structure. In order to increase the level of operating leverage, pharmacy institutions are recommended to reduce the variable part of costs, in particular, to look for cheaper suppliers, to increase the volume of purchases, to refuse piece-rate payment of pharmacists, etc.
MODERN INTERACTIVE TECHNOLOGIES OF MANAGEMENT IN PROMOTION OF SERVICES OF THE HOTEL AND RESTAURANT BUSINESS
Authors: Burak V. H. , Tyukhtenko N. A.
Published: November 2023

The article address the theoretical and methodological aspects of the application of interactive management technologies in the promotion of services by enterprises of the hotel and restaurant business. It is emphasized that Industry 4.0 focuses on the transformation of the value chain by means of "smart technologies", Industry 5.0 on triple impact - economic, environmental and social with ESG emphasis and balance (environment, social sphere and governance). The needs of hotel and restaurant business enterprises, which compete for consumers in the conditions of Industries 4.0 and 5.0, are highlighted, seeking to develop and provide unique services using all possible modern management technologies: interactive, digital, multimedia, event management, etc. The digitalization of the hotel and restaurant business is being updated, which is taking place thanks to the introduction of a complex of digital technologies and processes by enterprises, organizations, and institutions. The main ones are identified with the use of QR-coding, the provision of digital information to consumers through electronic devices, the implementation of remote communication with service customers through specialized websites, pages in social networks, specialized mobile applications, specialized chatbots, the use of special information programs for the management of the institution , electronic payment of services, etc. The experience of using smart digital technologies is analyzed. It was determined that the following digital technologies are relevant for hotel and restaurant businesses: social media, large databases, e-commerce, the Internet of Things (IOT), robotics, artificial intelligence, additive technologies (3D printing), blockchain, biometric technologies etc.
PROGNOSTICATION THE DYNAMICS OF THE DEVELOPMENT OF ORGANIZATIONAL AND TECHNOLOGICAL SYSTEMS
Authors: Zakharchenko V. I. , Oneshko S. V.
Published: November 2023

The article highlights an attempt to solve one of the most important problems of modern economic science – forecasting the creation and functioning of organizational and technological systems in domestic production. In the current military and economic conditions, the condition for the implementation of an innovative model of the development of the national economy through the functioning of organizational and technological systems in its industrial production is considered. The process of functioning of such systems consists of the continuous implementation of production cycles "money – technology – modern materials – production – sales". It is a feedback system and is described by differential equations. Non-linearity leads to the emergence of similar structures and their hierarchical construction. Since the capabilities of any organizational and technological system are limited, that is, the coupling coefficients between the output and input signals in the feedback system are proportional to the output signal, then the organizational and technological system is a nonlinear dynamic system. Such systems are described by nonlinear differential or iterative equations. It was determined that the potential income, that is, the income associated with the elimination of the monopoly of the organizational and technological system, and the real income in the free market are mutually complementary quantities (analogous to the potential and kinetic energy of a physical system). According to the principle of additionality, states in which such quantities had precisely certain values today been impossible. It follows from the above that the economy with hired labor and private property is relatively free, and the Western model cannot be considered as the only one when choosing the ways of economic development of the country. Such a model is an economy based on a market free from monopolies. It should be based on protected private property and democratic right of disposal – share-based personalized financial leasing (rent). And since nonlinear systems are characterized by cooperative behavior of their elements, it is conceivably to call this type of economy as a system of civilized cooperators, that is, market socialism.
A plenitude de capinar e tanger a boiada na roça: deixar-se ser-docente em escolas da roça
Authors: Mota Charles Maycon de Almeida
Published: November 2023

Com o presente estudo, buscou-se compreender como professores e professoras que atuam em escolas da roça constituem a presentificação do ser-na-roça para significar sua existência a partir da ruralidade da presença e produzem experiências de ser-docente numa perspectiva do ser-mais que habita espaços rurais. O método utilizado foi a Pesquisa Narrativa, com ênfase no movimento biográfico-narrativo, associada à abordagem qualitativa e ancorada nas bases da fenomenologia e da hermenêutica. Os dispositivos de pesquisa utilizados foram as entrevistas narrativas e das etnografias na roça, estes significaram possibilidade de recolha e de produção de dados. Conclui-se que deixar-se ser-docente aqui, está numa configuração daquilo que o ser-na-roça se revela num ente que é abertura constante e não se apega a um conjunto de normas e convenções sociais instituídas pelos parâmetros urbanocêntricos, mesmo tendo influência de uma formação pautada neste parâmetro.
EMPLOYER BRANDING AS A TOOL FOR EMPLOYEE LOYALTY: THE CASE OF MOROCCAN COMPANIES LISTED ON CASABLANCA STOCK EXCHANGE
Authors:   Research Professor, ENCG EL Jadida, University Chouaib Doukkali, Morocco, Ouachi Soukayna , Alaoui Meriem ,   Research Professor, ENSA Fes, University Sidi Mohamed Ben Abdellah, Morocco
Published: November 2023

To attract qualified profiles, known as talents, and to retain them, many enterprises are actively leveraging on employer branding. The objective of this research is to shed light on the role played by the concept of employer branding, defined as the set of brand image assets with respect to employees and their impact on human resources loyalty. Our hypothetico-deductive research method will be completed by conducting an empirical study based on a series of semi-structured interviews with 10 large companies listed on Casablanca stock exchange market. We suggest a model to articulate the employer brand around three key dimensions: low propensity to seek a new job, affective engagement and task performance. The collected and analyzed feedback led us to a clear and obvious conclusion. The intention to leave the company, the affective commitment as well as the performance in the task are directly impacted by the attributes of the employer brand. Therefore, organizational loyalty is influenced by the employer brand. The latter is a powerful loyalty tool that allows the company to retain talent. Further research should be conducted to explore the potential of employer branding as a powerful tool for talent retention.
HOW IS MASCULINE IDEOLOGY REPRESENTED IN RADITYA DIKA'S STAND-UP COMEDY?
Authors:   Department of Communication Science, Universitas Islam Indonesia, Yogyakarta, Indonesia, Faizti Nurfadhela , Tanjung Sumekar ,   Department of Communication Science, Universitas Islam Indonesia, Yogyakarta, Indonesia
Published: November 2023

This research aims to explicate how the ideology of masculinity is represented in Raditya Dika's stand-up comedy. Stand-Up Comedy Raditya Dika (SUCRD) is a collection of stand-up comedy performances created by comedian and writer Raditya Dika since 2016. Humor centered around masculinity and all things related to it consistently features in Raditya Dika's stand-up material. Using Roland Barthes' semiotic approach, this research examines masculinity within the context of SUCRD performances, with a specific focus on one episode titled Cowok Goblok featuring two monologues. This episode serves as an illustrative example of how masculine ideology is represented. The researcher limits the scope to one episode to avoid data saturation. Two key findings emerge from this study. Firstly, masculine ideology is conveyed verbally through the use of affiliative humor and self-enhancing humor. Secondly, masculine ideology is represented through narratives about decision-making, maturity, characteristics, expectations, and appearance of men. Stand-up comedy serves as a medium and space for the perpetuation of masculinity.
AN UNADORNED ADORNMENT: THE AESTHETICS EXPERIENCE OF AN ALTERITY IN THE JEWELRY
Authors:   Ph.D., Design, Faculty of Decorative Arts, Silpakorn University, Bangkok, Thailand, Sreekullkorn Tataroschong
Published: November 2023

Adornment of the human body is a cultural practice commonly found among all races and nationalities. These adornments represent their identities. Humans have created decorative pieces called jewelry, and each item plays a different role. Jewelry made from valuable materials is often considered expensive and symbolizes a wealthy status, as in this capitalist world, expensive objects are associated with the rich. Jewelry reflects a person's character, which is often intertwined with various subcultures. The materials used in jewelry represent one's sense of self, with markings on the body showcasing their character and spiritual connection to the object. The selection of materials is driven by the desire to express different facets of their identities. Those who fail to grasp the true meaning of these identities will not understand the genuine reasons for wearing these items. In the 21st century, global warming has spurred a move towards more sustainable design. Environmentally friendly production has become the new trend, where materials are chosen to reflect the essence of true adornment, while also being mindful of the environment. This growing environmental awareness has inspired action to support a long-lasting and eco-friendly environment.
THE DETERMINANTS OF STUDENT’S INTENTION TO USE DIGITAL WALLET
Authors:   Master of Education, Lecturer, Department of Economic Education, Faculty of Economics, Universitas Negeri Semarang, Semarang, Indonesia, Pramusinto Hengky , Nurkhin Ahmad ,   Master of Accounting, Associate Professor, Department of Economic Education, Faculty of Economics, Universitas Negeri Semarang, Semarang, Indonesia, Kardoyo Kardoyo ,   Doctor of Education, Professor, Department of Economic Education, Faculty of Economics, Universitas Negeri Semarang, Semarang, Indonesia, Setiaji Khasan ,   Master of Education, Lecturer, Department of Economic Education, Faculty of Economics, Universitas Negeri Semarang, Semarang, Indonesia, Puspadiningrum Dwi Noor Rachmawati ,   Bachelor of Education, Student, Department of Economic Education, Faculty of Economics, Universitas Negeri Semarang, Semarang, Indonesia
Published: November 2023

There are many digital wallets service were used by Indonesian customers during the COVID-19 pandemic. This study aims to analyze the determinants of students' intentions to use digital wallet based on the unified theory of acceptance and use of technology (UTAUT). The research sample is Universitas Negeri Semarang (UNNES) students who have used digital wallet in online purchase transactions. The sampling technique used in this study was incidental sampling. This survey has 135 participants. Data was gathered using questionnaires. Partial Least Squares Structural Equation Modeling (PLS-SEM) was used to analyze the data. The study's findings suggest that performance expectations, facilitating conditions, and habits can influence students' intentions to use digital wallet positive and significantly Meanwhile, it was found that effort expectancy, social influence, hedonic motives, and price value were not determinants of students' intention to use digital wallet. The other results show that students' online shopping habits influence their intention and behavior to continue using digital wallet. Students will find it easier to make purchases online. Furthermore, students have high-quality smartphones. The intention and behavior of using digital wallets will significantly increase. The future of research agenda is to explore the theory of online shopping behavior and digital wallet usage.
WHAT KIND OF LEARNING MEDIA THAT LECTURERS AND STUDENTS WANT? NEED ANALYSIS ON HYBRID SCIENCE LEARNING
Authors:   Lecturer, Primary School Teacher Education Department, Universitas Negeri Semarang, Semarang, Indonesia, Isdaryanti Barokah , Ahmadi Farid ,   Lecturer, Primary School Teacher Education Department, Universitas Negeri Semarang, Semarang, Indonesia, Nuzulia Siti ,   Lecturer, Psychology Department, Universitas Negeri Semarang, Semarang, Indonesia, Wahyuningrum Indah Fajarini Sri ,   Lecturer, Accounting Department, Universitas Negeri Semarang, Semarang, Indonesia, Irvan Moh. Farizqo ,   Lecturer, Primary School Teacher Education Department, Universitas Negeri Semarang, Semarang, Indonesia
Published: November 2023

The pandemic that has passed had an impact on the field of education, one of which is in hybrid science learning. This study aims to obtain information related to the learning media needed by students and lecturers in hybrid science learning. The research method applied is quantitative research with data collection techniques, namely through questionnaires. The population of this study was 120 students and 5 lecturers in the Department of Elementary School Teacher Education, Universitas Negeri Semarang. The data were analyzed using a descriptive quantitative approach. The results of the study indicate that there is a need to develop hybrid learning media in science learning. Lecturers and students agree that they need learning media that can support science learning in the form of technology-based media, contain contextual learning materials, supported by image, and can present real elements. This is assessed by lecturers and students to make it easier to understand the learning material. Thus, it can be understood that the development of science learning media with the previously mentioned criteria is needed in improving students' understanding of science concepts in hybrid science learning.
COMPLIANCE LEVEL ANALYSIS OF COVID-19 HEALTH PROTOCOL AMONG KARANG TARUNA MEMBERS AT PANDANLANDUNG VILLAGE, MALANG
Authors: Wardani Hartati Eko , Tama Tika Dwi , Gayatri Rara Warih , Wahidah Putri Djamilah
Published: November 2023

Introduction: One of the keys to success in efforts to overcome the COVID-19 pandemic is to comply with health protocols. The COVID-19 health protocol compliance level is known to be low in the adolescent age group. The low level of compliance is related to the role of Karang Taruna as a village-level organization in providing education and examples to their peers, namely adolescents. Aims: This study was conducted to describe the level of compliance of Karang Taruna members in Pandanlandung Village, Wagir District, Malang Regency to the COVID-19 Health Protocol. Methods: The design used in this research is cross sectional with a quantitative descriptive method. This research was conducted in March-October 2021 with the number of respondents as many as 24 members of the Karang Taruna Pandanlandung Village who were selected using a total sampling technique. Results: This research study found that the compliance level of members of the Karang Taruna Pandanlandung Village was in the "Good" category, especially in the aspects of "Using Masks" 70.83%, "Washing Hands" 79.17%, "Avoiding Crowds" 50% and "Limiting Mobility" 50%. Conclusion: from this study is that, in general, the implementation of the COVID-19 health protocol is good, but the implementation of health protocols in daily life must still be improved by reminding fellow members of Karang Taruna to continue to carry out the health protocol because the pandemic is not over so as to reduce the transmission rate of COVID-19.