bluuebunny/crossref_metadata_2025 huggingface dataset:
SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates
Authors: Alimohammadi Reza , Porgoo Meysam , Eftekhary Mohamad , Kiaie Seyed Hossein , Ansari Dezfouli Ehsan , Dehghani Maryam , Nasrollahi Kaveh , Malekshahabi Talieh , Heidari Maryam , Pouya Sedigheh , Alimohammadi Masoumeh , Sattari Khavas Dorsa , Modaresi Mohammad Sadra , Ghasemi Mohammad Hossein , Ramyar Hamed , Mohammadipour Fatemeh , Hamzelouei Fateme , Mofayezi Ahmadreza , Mottaghi Seyed Saeed , Rahmati Amirhosein , Razzaznian Mohsen , Tirandazi Vista , Tat Mahdi , Borzouee Fatemeh , Sadeghi Hossein , Haji Mohammadi Melika , Rastegar Leila , Safar Sajadi Seyed Milad , Ehsanbakhsh Hossein , Bazmbar Hamed , Baghernejadan Zeinab , Shams Nouraei Maedeh , Pazooki Pouya , Pahlavanneshan Mina , Alishah Khadijeh , Nasiri Fateme , Mokhberian Neda , Mohammadi Seyedeh Shima , Akar Shima , Niknam Hamidreza , Azizi Marzieh , Ajoudanian Mohammad , Moteallehi-Ardakani Mohammad Hossein , Mousavi Shaegh Seyed Ali , Ramezani Reihaneh , Salimi Vahid , Moazzami Reza , Hashemi Seyed Mahmoud , Dehghanizadeh Somaye , Khoddami Vahid
Published: September 2022

At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations. This strategic powerful platform has recently been used to immunize millions of people proving both of safety and highest level of clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report of COReNAPCIN®; a vaccine candidate against SARS-CoV-2 infection. COReNAPCIN® is a nucleoside modified mRNA-based vaccine formulated in lipid nanoparticles (LNPs) for encoding the full-length prefusion stabilized SARS-CoV-2 spike glycoprotein on the cell surface. Vaccination of C57BL/6 and BALB/c mice and rhesus macaque with COReNAPCIN® induced strong humoral responses with high titers of virus-binding and neutralizing antibodies. Upon vaccination, a robust SARS-CoV-2 specific cellular immunity was also observed in both mice and non-human primate models. Additionally, vaccination protected rhesus macaques from symptomatic SARS-CoV-2 infection and pathological damage to the lung upon challenging the animals with high viral loads of up to 2 × 108 live viral particles. Overall, our data provide supporting evidence for COReNAPCIN® as a potent vaccine candidate against SARS-CoV-2 infection for clinical studies.
Soft computing and statistical approach for sensitivity analysis of heat transfer through the hybrid nanoliquid film in rotating heat pipe
Authors: Uddin Ziya , Hassan Hamdy , Harmand Souad , Ibrahim Wubshet
Published: September 2022

In this paper, the numerical solution for heat transfer through a rotating heat pipe is studied and a sensitivity analysis is presented by using statistical experimental design technique. Graphene oxide-molybdenum disulfide (GO-MoS2) hybrid nanofluid is taken as working fluid inside the pipe. The impact of the heat pipe parameters (rotation speed, initial mass, temperature difference) on the heat transfer and liquid film thickness is investigated. The mathematical model coupling the fluid mass flow rate and liquid film evolution equations in evaporator, adiabatic, and condenser zones of the heat pipe is constructed. The mathematical model is solved by implementation of “Particle Swarm Optimization” along with the finite difference method. The outcomes demonstrate that hybrid nanoparticles help to improve the heat transfer through the heat pipe and reduce liquid film thickness. The heat transfer rises with increasing temperature difference and reducing inlet mass, and it reduces slightly with rising rotation speed. The difference in liquid film thickness between the evaporator and condenser zones increases with increasing temperature difference and decreasing rotation speed. The impact of increasing the volume fraction of GO on the liquid film thickness is higher than that in the case of the MoS2nanoparticles. However, an increase of the heat transfer is noticed in case of increasing the volume fraction of GO relative to increasing MoS2concentration. Statistical analysis of the computed numerical data and the identification of significant parameters for total heat transfer are found using the response surface method. At 95% level of significance, the GO concentration in the hybrid nanofluid, inlet mass of the hybrid nanofluid and the temperature difference inside the evaporator zone of the pipe are found to be significant linear parameters for increasing heat transfer.
Neuromuscular exercise in children with Down Syndrome: a systematic review
Authors: Rodríguez-Grande Eliana-Isabel , Vargas-Pinilla Olga-Cecilia , Torres-Narvaez Martha-Rocio , Rodríguez-Malagón Nelcy
Published: September 2022

The effects and the prescription parameters of therapeutic exercise are not clear. For this reason, is needed to determine the effect of neuromuscular exercise on balance, muscle strength and flexibility specifying the parameters and characteristics of effective interventions in children between 6 and 12 years and adolescent between 13 and 18 years with Down Syndrome. The present study is a systematic review of effectiveness outcomes balance, muscle strength and flexibility in this population. The databases of PubMed, PEDro, EMBASE, SCIELO, Lilacs, Cochrane library were searched from May to December 2021. We recruited randomized controlled trials (RCTs) which met the inclusion criteria in our study. Ten studies were included. The interventions included mechanotherapy, vibration, and use of different unstable surfaces. The exercise frequency ranged from 3 to 5 days a week, and the duration of each session was between six and 15 min. The frequency was between two and three times a week for 6 and 12 weeks and the intensity were between 60 and 80% of maximal voluntary contraction. Neuromuscular exercise in different modes of application was associated with increases in chest and lower limb muscle strength mean 8.51, CI [2.35–14.67] kg and (21.54 [1.64, 41.43]) kg. Balance also improved when the mode of application was isokinetic training and core stability exercises (− 0.20 [− 0.29, − 0.12]) evaluated with stability index. Neuromuscular exercise appears to be effective for the improvement of both lower limb and chest muscle strength and balance in children over 8 years. No evidence was found in children under 8 years.
A universal similarity based approach for predictive uncertainty quantification in materials science
Authors: Korolev Vadim , Nevolin Iurii , Protsenko Pavel
Published: September 2022

Immense effort has been exerted in the materials informatics community towards enhancing the accuracy of machine learning (ML) models; however, the uncertainty quantification (UQ) of state-of-the-art algorithms also demands further development. Most prominent UQ methods are model-specific or are related to the ensembles of models; therefore, there is a need to develop a universal technique that can be readily applied to a single model from a diverse set of ML algorithms. In this study, we suggest a new UQ measure known as the Δ-metric to address this issue. The presented quantitative criterion was inspired by the k-nearest neighbor approach adopted for applicability domain estimation in chemoinformatics. It surpasses several UQ methods in accurately ranking the predictive errors and could be considered a low-cost option for a more advanced deep ensemble strategy. We also evaluated the performance of the presented UQ measure on various classes of materials, ML algorithms, and types of input features, thus demonstrating its universality.
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Authors: Zarei Iman , Koistinen Ville M. , Kokla Marietta , Klåvus Anton , Babu Ambrin Farizah , Lehtonen Marko , Auriola Seppo , Hanhineva Kati
Published: September 2022

The essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an interactive host-microbiota metabolic signaling, impacting metabolic phenotypes of the host. Dysbiosis of microbiota results in alteration of certain microbial and host metabolites. Identifying these markers could enhance early detection of certain diseases. We report LC–MS based non-targeted metabolic profiling that demonstrates a large effect of gut microbiota on mammalian tissue metabolites. It was hypothesized that gut microbiota influences the overall biochemistry of host metabolome and this effect is tissue-specific. Thirteen different tissues from germ-free (GF) and conventionally-raised (MPF) C57BL/6NTac mice were selected and their metabolic differences were analyzed. Our study demonstrated a large effect of microbiota on mammalian biochemistry at different tissues and resulted in statistically-significant modulation of metabolites from multiple metabolic pathways (p ≤ 0.05). Hundreds of molecular features were detected exclusively in one mouse group, with the majority of these being unique to specific tissue. A vast metabolic response of host to metabolites generated by the microbiota was observed, suggesting gut microbiota has a direct impact on host metabolism.
Loneliness and its correlates among Bangladeshi older adults during the COVID-19 pandemic
Authors: Mistry Sabuj Kanti , Ali A. R. M. Mehrab , Yadav Uday Narayan , Huda Md. Nazmul , Ghimire Saruna , Saha Manika , Sarwar Sneha , Harris Mark F.
Published: September 2022

The present study aims to investigate the prevalence of loneliness and its associated factors among older adults during the COVID-19 pandemic in Bangladesh. This cross-sectional study was conducted in October 2020 among 1032 older Bangladeshi adults aged 60 years and above through telephone interviews. A semi-structured questionnaire was used to collect information on participants’ characteristics and COVID-19-related information. Meanwhile, the level of loneliness was measured using a 3-item UCLA Loneliness scale. More than half (51.5%) of the older adults experienced loneliness. We found that participants formally schooled [adjusted odds ratio (aOR = 0.62, 95% CI 0.43–0.88)] and received COVID-19-related information from health workers (aOR = 0.33, 95% CI 0.22–0.49) had lower odds of being lonely during the pandemic. However, older adults living alone (aOR: 2.57, 95% CI 1.34–4.94), residing distant from a health facility (aOR = 1.46, 95% CI 1.02–2.08) and in rural areas (aOR = 1.53, 95% CI 1.02–2.23) had higher odds of loneliness than their counterparts. Likewise, odds of loneliness were higher among those overwhelmed by COVID-19 (aOR = 1.93, 95% CI 1.29–2.86), who faced difficulty in earning (aOR = 1.77, 95% CI 1.18–2.67) and receiving routine medical care during pandemic (aOR = 2.94, 95% CI 1.78–4.87), and those perceiving requiring additional care during the pandemic (aOR = 6.01, 95% CI 3.80–9.49). The findings suggest that policies and plans should be directed to reduce loneliness among older adults who require additional care.
Phase I trial of Bermekimab with nanoliposomal irinotecan and 5-fluorouracil/folinic acid in advanced pancreatic ductal adenocarcinoma
Authors: Gong Jun , Thomassian Shant , Kim Sungjin , Gresham Gillian , Moshayedi Natalie , Ye Jason Y. , Yang Julianne C. , Jacobs Jonathan P. , Lo Simon , Nissen Nick , Gaddam Srinivas , Tighiouart Mourad , Osipov Arsen , Hendifar Andrew
Published: September 2022

In this phase I dose-escalation trial, we assess the maximum tolerated dose (MTD) of Bermekimab in combination with Nanoliposomal Irinotecan (Nal-Iri) and 5-Fluorouracil/Folinic Acid (5-FU/FA). Secondarily, we investigate effects on weight, lean body mass, quality-of-life, the gut microbiome composition, inflammatory biomarkers, progression-free survival, and overall survival. This was a single-arm, open-label adaptive Bayesian dose-escalation study of Bermekimab combined with Nal-Iri and 5FU/FA in patients with advanced or locally advanced PDAC who failed gemcitabine-based chemotherapy. 22 patients enrolled between 2017 and 2019. 3 of 21 patients experienced dose-limiting toxicities attributable to the chemotherapy backbone. 58% (10/17) of patients exhibited weight stability. Physical performance status was preserved among all subjects. Patients reported improvements in quality-of-life metrics via QLQ-PAN26 questioner (−3.6, p = 0.18) and functional well-being (1.78, p = 0.02). Subjects exhibited a decrease in inflammatory cytokines, notably, vascular endothelial growth factor (−0.86, p = 0.017) with Bermekimab. Bermekimab treatment was associated with an increased abundance of gut health-promoting bacterial genera Akkermansia, with 3.82 Log2-fold change from baseline. In sum, Bermekimab is safe to be used in conjunction with Nal-Iri and 5-FU/FA chemotherapy. This benign toxicological profile warrants further Phase I/II investigation of Bermekimab in combinatorial strategies, and the impact of anti-IL-1α antibodies on the gut microbiome.

Clinical trials registration: NCT03207724 05/07/2017.
Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma
Authors: Cleary James M. , Rouaisnel Betty , Daina Antoine , Raghavan Srivatsan , Roller Lauren A. , Huffman Brandon M. , Singh Harshabad , Wen Patrick Y. , Bardeesy Nabeel , Zoete Vincent , Wolpin Brian M. , Losman Julie-Aurore
Published: September 2022

The mutant IDH1 inhibitor ivosidenib improves outcomes for patients with IDH1-mutated cholangiocarcinoma, but resistance inevitably develops. Mechanisms of resistance and strategies to overcome resistance are poorly understood. Here we describe two patients with IDH1 R132C-mutated metastatic cholangiocarcinoma who developed acquired resistance to ivosidenib. After disease progression, one patient developed an oncogenic IDH2 mutation, and the second patient acquired a secondary IDH1 D279N mutation. To characterize the putative IDH1 resistance mutation, cells expressing the double-mutant were generated. In vitro, IDH1 R132H/D279N produces (R)-2HG less efficiently than IDH1 R132H. However, its binding to ivosidenib is impaired and it retains the ability to produce (R)-2HG and promote cellular transformation in the presence of ivosidenib. The irreversible mutant IDH1 inhibitor LY3410738 binds and blocks (R)-2HG production and cellular transformation by IDH1 R132H/D279N. These resistance mechanisms suggest that IDH1-mutated cholangiocarcinomas remain dependent on (R)-2HG even after prolonged ivosidenib treatment. Sequential mutant IDH inhibitor therapy should be explored as a strategy to overcome acquired resistance to mutant IDH inhibitors.
Immune response to SARS-CoV-2 Omicron variant in patients and vaccinees following homologous and heterologous vaccinations
Authors: Trombetta Claudia Maria , Piccini Giulia , Pierleoni Giulio , Leonardi Margherita , Dapporto Francesca , Marchi Serena , Andreano Emanuele , Paciello Ida , Benincasa Linda , Lovreglio Piero , Buonvino Nicola , Decaro Nicola , Stufano Angela , Lorusso Eleonora , Bombardieri Emilio , Ruello Antonella , Viviani Simonetta , Rappuoli Rino , Molesti Eleonora , Manenti Alessandro , Montomoli Emanuele
Published: September 2022

The SARS-CoV-2 Omicron variant has rapidly replaced the Delta variant of concern. This new variant harbors worrisome mutations on the spike protein, which are able to escape the immunity elicited by vaccination and/or natural infection. To evaluate the impact and susceptibility of different serum samples to the Omicron variant BA.1, samples from COVID-19 patients and vaccinated individuals were tested for their ability to bind and neutralize the original SARS-CoV-2 virus and the Omicron variant BA.1. COVID-19 patients show the most drastic reduction in Omicron-specific antibody response in comparison with the response to the wild-type virus. Antibodies elicited by a triple homologous/heterologous vaccination regimen or following natural SARS-CoV-2 infection combined with a two-dose vaccine course, result in highest neutralization capacity against the Omicron variant BA.1. Overall, these findings confirm that vaccination of COVID-19 survivors and booster dose to vaccinees with mRNA vaccines is the correct strategy to enhance the antibody cross-protection against Omicron variant BA.1.
Spike-based adenovirus vectored COVID-19 vaccine does not aggravate heart damage after ischemic injury in mice
Authors: Gu Shanshan , Chen Zhongyan , Meng Xiangfu , Liu Ge , Xu He , Huang Liying , Wu Linwei , Gong Jixing , Chen Ding , Xue Bingqing , Zhu Lihang , Wan Zhongjun , Lin Jianqing , Cai Xiaolong , Zhang Xiaoyan , Wang Jia , Zhang Donghui , Cao Nan
Published: September 2022

An unprecedented number of COVID-19 vaccination campaign are under way worldwide. The spike protein of SARS-CoV-2, which majorly binds to the host receptor angiotensin converting enzyme 2 (ACE2) for cell entry, is used by most of the vaccine as antigen. ACE2 is highly expressed in the heart and has been reported to be protective in multiple organs. Interaction of spike with ACE2 is known to reduce ACE2 expression and affect ACE2-mediated signal transduction. However, whether a spike-encoding vaccine will aggravate myocardial damage after a heart attack via affecting ACE2 remains unclear. Here, we demonstrate that cardiac ACE2 is up-regulated and protective after myocardial ischemia/reperfusion (I/R). Infecting human cardiac cells or engineered heart tissues with a spike-based adenovirus type-5 vectored COVID-19 vaccine (AdSpike) does not affect their survival and function, whether subjected to hypoxia-reoxygenation injury or not. Furthermore, AdSpike vaccination does not aggravate heart damage in wild-type or humanized ACE2 mice after I/R injury, even at a dose that is ten-fold higher as used in human. This study represents the first systematic evaluation of the safety of a leading COVID-19 vaccine under a disease context and may provide important information to ensure maximal protection from COVID-19 in patients with or at risk of heart diseases.
Ecological effects of stress drive bacterial evolvability under sub-inhibitory antibiotic treatments
Authors: Vasse Marie , Bonhoeffer Sebastian , Frenoy Antoine
Published: September 2022

Stress is thought to increase mutation rate and thus to accelerate evolution. In the context of antibiotic resistance, sub-inhibitory treatments could then lead to enhanced evolvability, thereby fuelling the adaptation of pathogens. Combining wet-lab experiments, stochastic simulations and a meta-analysis of the literature, we found that the increase in mutation rates triggered by antibiotic treatments is often cancelled out by reduced population size, resulting in no overall increase in genetic diversity. A careful analysis of the effect of ecological factors on genetic diversity showed that the potential for regrowth during recovery phase after treatment plays a crucial role in evolvability, being the main factor associated with increased genetic diversity in experimental data.
Biomimetic fluorine-free 3D alternating hydrophilic–superhydrophobic surfaces with different bump morphologies for efficient water harvesting
Authors: Peng Zhouliang , Guo Zhiguang
Published: September 2022

Biomimetic 3D hydrophilic–superhydrophobic hybrid surfaces with bump structures were prepared by a combination of spin-coating and high-temperature calcination.
Selective functionalization of C(sp3)–H bonds: catalytic chlorination and bromination by IronIII-acacen-halide under ambient condition
Authors: Shen Chang , Dagnaw Wasihun Menberu , Fong Ching Wai , Lau Kai Chung , Chow Cheuk-Fai
Published: September 2022

The selective oxidative catalytic halogenation of the C(sp3)–H bond of alkanes was accomplished by FeIII(acacen)X (X = Cl and Br) in the presence of trifluoroacetic acid, halide, and H2O2.
Random projections and kernelised leave one cluster out cross validation: universal baselines and evaluation tools for supervised machine learning of material properties
Authors: Durdy Samantha , Gaultois Michael W. , Gusev Vladimir V. , Bollegala Danushka , Rosseinsky Matthew J.
Published: September 2022

Kernelised LOCO-CV can measure the extrapolatory power of an algorithm. Random projections are a versatile benchmark for composition featurisation.
Advancing the understanding of mainstream shortcut nitrogen removal: resource efficiency, carbon redirection, and plant capacity
Authors: McCullough Kester , Klaus Stephanie , Parsons Michael , Wilson Christopher , Bott Charles B.
Published: September 2022

Shortcut nitrogen removal (SNR) reduces aeration, carbon, and alkalinity requirements, but the magnitude of this benefit is often overstated. SNR allows for upstream carbon diversion and anammox processes allow for significant WRRF capacity gains.
Combining gellan gum with a functional low-molecular-weight gelator to assemble stiff shaped hybrid hydrogels for stem cell growth
Authors: Piras Carmen C. , Genever Paul G. , Smith David K.
Published: September 2022

Hybrid hydrogels combining gellan gum polymer gelator (PG) with a low molecular weight gelator (LMWG) benefit from both the synergistic combination of rheological characteristics and the unique activity of the LMWG.
Comparative evaluation of long non-coding RNA-based biomarkers in the urinary sediment and urinary exosomes for non-invasive diagnosis of bladder cancer
Authors: Qiu Tongtong , Xue Mei , Li Xu , Li Fangyuan , Liu Shanshan , Yao Chenyu , Chen Wei
Published: September 2022

A panel consisting of three urinary exosomal long non-coding RNAs has the potential to be biomarkers for non-invasive bladder cancer diagnosis.
Efficient shape transformation of palladium nanocrystals by biphasic oxidative etching and regrowth
Authors: Liu Zhaojun , Mu Zerui , Liu Kai , Wang Xiaoxiao , Qiao Zhun , Zhang Zhixue , Gao Chuanbo
Published: September 2022

A rapid transformation of Pd nanocubes into octahedrons has been achieved at high concentrations by a robust liquid–solid biphasic oxidative etching–regrowth strategy, with HNO2 playing a key role in the synthesis.
Association of two polyelectrolytes in salt solutions
Authors: Duan Chao , Wang Rui
Published: September 2022

The association of polyelectrolytes (PEs) in solution affects a wealth of structural and dynamic behavior, and is also fundamentally important for an understanding of protein association and aggregation.
A novel windmill-shaped AIE-active pyrrolopyrrole cyanine: design, synthesis and efficient hydrazine detection
Authors: Wang Lingyun , Xin Shuqi , Xie Furong , Ran Xueguang , Tang Hao , Cao Derong
Published: September 2022

A novel windmill-shaped AIE-active PPCy dye was developed and used for efficient hydrazine detection.
Synthesis, self-assembly and optical properties of some rigid π-bridged triphenylene dimers
Authors: Lin Hang , Zhao Ke-Xiao , Jing Min , Long Xiu-Hai , Zhao Ke-Qing , Hu Ping , Wang Bi-Qin , Lei Peng , Zeng Qing-Dao , Donnio Bertrand
Published: September 2022

π-Conjugated liquid-crystalline dimers consisting of two triphenylene mesogens connected through a rigid molecular bridge have been synthesized. Mesophases, gels and optical properties have been investigated as a function of the bridge nature.
White light emission with unity efficiency from Cs2Na1−xAgxIn1−yBiyCl6double perovskites: the role of bismuth and silver
Authors: Liu Fang , Simbula Angelica , Lai Stefano , Wu Luyan , Wang Qingqian , Marongiu Daniela , Pau Riccardo , Matta Selene , Pitzalis Federico , Geddo Lehmann Alessandra , Wang Kai , Filippetti Alessio , Quochi Francesco , Saba Michele , Mura Andrea , Bongiovanni Giovanni
Published: September 2022

Lead-free double perovskites are ideal lighting materials, capable of white light emission with unity efficiency. We demonstrate that the key ingredients for efficient emission are bismuth and silver with at least 0.1% fraction each.
Cryo-EM structure of human MG53 homodimer
Authors: Niu Yange , Chen Gengjia , Lv Fengxiang , Xiao Rui-Ping , Hu Xinli , Chen Lei
Published: September 2022

MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a ‘body’ and two ‘wings’. Intermolecular interactions are mainly distributed in the ‘body’ which is relatively stable, while two ‘wings’ are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family.
Validation of Muscle Fiber Architecture of the Human Tongue Revealed by Diffusion Magnetic Resonance Imaging With Histology Verification
Authors: Liang Xiao , Elsaid Nahla M. H. , Jiang Li , Roys Steve , Puche Adam C. , Gullapalli Rao P. , Stone Maureen , Prince Jerry L. , Zhuo Jiachen
Published: September 2022

Purpose:

The goal of this study is to validate the muscle architecture derived from both ex vivo and in vivo diffusion-weighted magnetic resonance imaging (dMRI) of the human tongue with histology of an ex vivo tongue.

Method:

dMRI was acquired with a 200-direction high angular resolution diffusion imaging (HARDI) diffusion scheme for both a postmortem head (imaged within 48 hr after death) and a healthy volunteer. After MRI, the postmortem head was fixed and the tongue excised for hematoxylin and eosin (H&E) staining and histology imaging. Structure tensor images were generated from the stained images to better demonstrate muscle fiber orientations. The tongue muscle fiber orientations, estimated from dMRI, were visualized using the tractogram, a novel representation of crossing fiber orientations, and compared against the histology images of the ex vivo tongue.

Results:

Muscle fibers identified in the tractograms showed good correspondence with those appearing in the histology images. We further demonstrated tongue muscle architecture in in vivo tractograms for the entire tongue.

Conclusion:

The study demonstrates that dMRI can accurately reveal the complex muscle architecture of the human tongue and may potentially benefit planning and evaluation of oral surgery and research on speech and swallowing.
Speech Perception Variability in Childhood Apraxia of Speech: Implications for Assessment and Intervention
Authors: Spencer Caroline , Davison Kelsey E. , Boucher Alyssa R. , Zuk Jennifer
Published: September 2022

Purpose:

Beyond hallmark production deficits characterizing childhood apraxia of speech (CAS), largely attributed to disruption(s) in speech motor planning, children with CAS often present with co-occurring speech perception and language difficulties. Thus, careful consideration of the potential for speech perception difficulties to have cascading downstream effects on intervention responsiveness and real-life functioning for some children with CAS is highly important. The purpose of this tutorial was to consider the impact of speech perception abilities in children with CAS, which carries implications for caring for the needs of the whole child.

Method:

This tutorial summarizes the current literature on speech perception and how it relates to speech production, language, and reading abilities for children with CAS. We include case illustrations that are adapted from real clinical scenarios illustrating how speech perception difficulties may impact some children with CAS and provide recommendations for incorporating speech perception into assessment and intervention practices.

Results:

Although speech perception difficulties do not seem to be a core deficit of CAS, they are strongly linked to language difficulties, which are highly prevalent among children with CAS. Speech perception and language difficulties are also associated with reading difficulties and risk for lower academic achievement.

Conclusions:

Children with CAS who have co-occurring language difficulties likely also demonstrate speech perception deficits, which puts them at heightened risk for reading difficulties and struggles with academic achievement. Comprehensive assessment of children with CAS should address speech perception and production, language, and reading abilities, which carries important implications for multifaceted approaches to intervention.
School-Based Speech-Language Pathologists' Attitudes and Knowledge About Trauma-Informed Care
Authors: Roberson Mikayla M. , Lund Emily
Published: September 2022

Purpose:

The purpose of this study was to evaluate the attitudes and knowledge of school-based speech-language pathologists toward trauma-informed care.

Method:

School-based speech-language pathologists (
N
= 116) completed the Attitudes Related to Trauma-Informed Care Scale Version 45 Education (ARTIC-45) survey via an online survey platform and provided information about their work experience, history with trauma training, and demographic variables.

Results:

Although speech-language pathologists had responses that, on average, aligned with trauma-informed perspectives, those perspectives varied and were not at ceiling. Characteristics such as age, years of experience, and foster care experience did not significantly influence the results, but self-rating of trauma-informed care knowledge did correlate with the ARTIC-45 survey. Participants who had engaged in trauma-informed care trainings had more trauma-informed perspectives and knowledge than participants who had not.

Conclusions:

The results of this study provide preliminary evidence that trauma-informed care trainings may benefit those speech-language pathologists working with children who have experienced trauma. This study also provides preliminary evidence supporting the validity of the ARTIC-45 for use with speech-language pathologists.
An improved Chase–Pyndiah algorithm in the iterative decoding of turbo product codes
Authors: Yang Tao , Xi Zhiyu , Sun Qifu Tyler
Published: September 2022

This paper considers the design of turbo product codes (TPCs) for short and bursty packages, which is suitable for low latency machine‐to‐machine type communication. A new soft syndrome‐based approach is proposed to compute the weighting factors in the iterative Chase–Pyndiah decoding of TPCs. A new soft syndrome estimation method is developed which has a manageable computational complexity. Numerical results show that the bit error rate performance is improved by using this simple approach for short package sizes for TPCs with high coding rates.
Characterization of the MASCOT landing area by Hayabusa2
Authors: Schröder Stefan , Sakatani Naoya , Honda Rie , Tatsumi Eri , Yokota Yasuhiro , Domingue Deborah , Cho Yuichiro , Kameda Shingo , Kitazato Kohei , Kouyama Toru , Matsuoka Moe , Miura Akira , Morota Tomokatsu , Okada Tatsuaki , Sawada Hirotaka , Senshu Hiroki , Shimaki Yuri , Sugita Seiji , Tanaka Satoshi , Yabuta Hikaru , Yamada Manabu , Grott Matthias , Hamm Maximilian , Ho Tra-Mi , Jaumann Ralf , Mottola Stefano , Otto Katharina , Schmitz Nicole , Scholten Frank
Published: September 2022

Context. After landing on C-type asteroid Ryugu, MASCOT imaged brightly colored, submillimeter-sized inclusions in a small rock. Hayabusa2 successfully returned a sample of small particles from the surface of Ryugu, but none of these appear to harbor such inclusions. The samples are considered representative of Ryugu.

Aims. To understand the apparent discrepancy between MASCOT observations and Ryugu samples, we assess whether the MASCOT landing site, and the rock by implication, is perhaps atypical for Ryugu.

Methods. We analyzed observations of the MASCOT landing area acquired by three instruments on board Hayabusa2: a camera (ONC), a near-infrared spectrometer (NIRS3), and a thermal infrared imager. We compared the landing area properties thus retrieved with those of the average Ryugu surface.

Results. We selected several areas and landforms in the landing area for analysis: a small crater, a collection of smooth rocks, and the landing site itself. The crater is relatively blue and the rocks are relatively red. The spectral and thermophysical properties of the landing site are very close to those of the average Ryugu surface. The spectral properties of the MASCOT rock are probably close to average, but its thermal inertia may be somewhat higher.

Conclusions. The MASCOT rock can also be considered representative of Ryugu. Some of the submillimeter-sized particles in the returned samples stand out because of their atypical spectral properties. Such particles may be present as inclusions in the MASCOT rock.
Morpho-kinematics of MACS J0416.1-2403 low-mass galaxies
Authors: Ciocan B. I. , Ziegler B. L. , Böhm A. , Verdugo M. , Maier C.
Published: September 2022

We use optical integral field spectroscopy from VLT/MUSE, as well as photometric observations from Hubble Space Telescope and VLT/HAWK-I, to study the morpho-kinematics of 17 low-mass (log(M/M⊙) < 9.5) MACS J0416.1-2403 cluster galaxies at R200 and five field galaxies with a redshift of z ∼ 0.4. By measuring fluxes of strong emission lines from the MUSE data, we have recovered the star formation rates, gas-phase metallicities, and spatially resolved gas kinematics, and we have also investigated the ionising mechanisms. We have analysed the structure and morphology of the galaxies from the optical and infrared photometric data, performing a multi-component decomposition into a bulge and a disk. The spatially resolved gas velocity fields of the cluster members and field galaxies were modelled using a 3D approach, which allowed us to retrieve their intrinsic gas kinematics, including the maximum rotation velocity and velocity dispersion. This enabled us to study scaling relations such as the Tully–Fisher and the stellar mass–S0.5 relation for low-mass galaxies in different environments and to search for signatures of cluster-specific processes using disturbed gas velocity fields as tracers. Most galaxies from our sample fall in the star-forming and composite region in the diagnostic diagram, which allows for the ionising sources in a galaxy to be disentangled. The cluster and field population can be classified as star-forming main-sequence galaxies, with only a sub-sample of four quenched systems. We observe significant scatter for the cluster galaxies in the mass-metallicity plane, and the lowest-mass systems deviate from the predictions of the fundamental metallicity relation, showing higher metallicities, whereas the higher-mass ones are in accordance with the model predictions. This might hint at the cutoff of pristine gas inflow and/or the removal of the hot halo gas as the mechanisms driving these offsets. Our morpho-kinematic analysis reveals a sub-sample of dwarfs with maximum velocities vmax < 50 km s−1 and vmax, gas/σgas < 1, which depart from the Tully–Fisher relation. This might indicate that their interstellar medium is affected by external environmental processes, such as ram pressure stripping. However, ∼30% of the cluster galaxies have rotation-dominated gas disks and follow the Tully–Fisher relation within 1σ. Using the S0.5 parameter, which links the dynamical support of ordered motions with that of random motions, we can differentiate between galaxies affected by gravitational processes and systems affected by hydrodynamical ones. In the stellar mass–S0.5 plane, both cluster and field galaxies follow a tight sequence, with only a sub-population of five galaxies strongly departing (> 4σ) from this relation, showing high σgas values. Both the morphology and kinematics of the outlier galaxies hint at a combination of pre-processing and cluster-specific interactions affecting their stellar and gas disks.
KMT-2017-BLG-0673Lb and KMT-2019-BLG-0414Lb: Two microlensing planets detected in peripheral fields of KMTNet survey
Authors: Han Cheongho , Lee Chung-Uk , Gould Andrew , Jung Youn Kil , Albrow Michael D. , Chung Sun-Ju , Hwang Kyu-Ha , Kim Doeon , Ryu Yoon-Hyun , Shin In-Gu , Shvartzvald Yossi , Yang Hongjing , Yee Jennifer C. , Zang Weicheng , Cha Sang-Mok , Kim Dong-Jin , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W.
Published: September 2022

Aims. We investigate the microlensing data collected during the 2017–2019 seasons in the peripheral Galactic bulge fields with the aim of finding planetary signals in microlensing light curves observed with relatively sparse coverage.

Methods. We first sort out lensing events with weak short-term anomalies in the lensing light curves from the visual inspection of all non-prime-field events, and then test various interpretations of the anomalies. From this procedure, we find two previously unidentified candidate planetary lensing events KMT-2017-BLG-0673 and KMT-2019-BLG-0414. It is found that the planetary signal of KMT-2017-BLG-0673 was produced by the source crossing over a planet-induced caustic, but it was previously missed because of the sparse coverage of the signal. On the other hand, the possibly planetary signal of KMT-2019-BLG-0414 was generated without caustic crossing, and it was previously missed due to the weakness of the signal. We identify a unique planetary solution for KMT-2017-BLG-0673. However, for KMT-2019-BLG-0414, we identify two pairs of planetary solutions, for each of which there are two solutions caused by the close-wide degeneracy, and a slightly less favored binary-source solution, in which a single lens mass gravitationally magnified a rapidly orbiting binary source with a faint companion (xallarap).

Results. From Bayesian analyses, it is estimated that the planet KMT-2017-BLG-0673Lb has a mass of 3.7−2.1+2.2 MJ, and it is orbiting a late K-type host star with a mass of 0.63−0.35+0.37 M⊙. Under the planetary interpretation of KMT-2010-BLG-0414L, a star with a mass of 0.74−0.38+0.43 M⊙ hosts a planet with a mass of ~3.2–3.6 MJ depending on the solution. We discuss the possible resolution of the planet-xallarap degeneracy of KMT-2019-BLG-0414 by future adaptive-optics observations on 30 m class telescopes. The detections of the planets indicate the need for thorough investigations of non-prime-field lensing events for the complete census of microlensing planet samples.
Wideband meta-material-inspired reconfigurable antenna using Infinity Split Ring Resonator
Authors: Zerrouk Zohra , Setti Larbi
Published: September 2022

In this article, a reconfigurable antenna inspired by the broadband meta-material using the Infinity slotted ring resonator (I-SRR) is designed and computer-based for wireless communication. Antenna takes an infinitely split ring resonator as a radiator powered by a coplanare wave guide (CPW). The procedure for extracting parameters of the meta-material property of the I-SRR is discussed in detail, by which the existence of negative permeability and the new resonance frequencies are verified. The proposed antenna has advantages of simple design, miniaturisation that can be used for wireless mobile communication system.
RFID System for Respiratory Rate Monitoring
Authors: Araujo Jéssyca I. L. , Serres Alexandre J. R. , Santos Danilo F. S.
Published: September 2022

In this work, an RFID system was developed to monitor the respiratory rate. This monitoring was based on variations in the Received Signal Strength Indicator (RSSI) by the reader due to respiratory movements. In some breath measurement configurations, the maximum read range was greater than 1 m, which is the distance considered in the measurement configurations described in some scientific papers. The RSSI data, obtained by reading the RFID tag, were processed using the Daubechies wavelet of order 3 (db3) and considering three levels of signal decomposition. Less noisy breathing signals were obtained in the measurements with the participant seated and the RFID tag with the polyethylene foam on the abdomen. The respiratory frequencies acquired from the variations of the RSSI parameter were validated by comparison with the results obtained using a vital signals monitor.
Characterization of Low-Cost UWB MIMO antenna model for K/Ka/Q/U/V bands Applications
Authors: Berkat Abdellatif , Berkat Zeyneb , Hacene Noureddine Boukli , Latrach Mohamed
Published: September 2022

A dual-element and a four elements low-cost multiple-input-multiple-output (MIMO) antenna are introduced in this paper. It achieves a bandwidth (BW) of 25 GHz (22-45 GHz) and 35 GHz (22- 60 GHz) respectively, and the VSWR is less than 2 for both configurations. The proposed antennas average isolation of 20 dB over the entire operating band, and a peak realized gain of 7.6 dBi for the dual element antenna and 7.59 dBi for the four-element antenna, which are suitable for ultra-wideband at K/Ka/Q/U/V bands Applications.
A New Design of 5G Planar Antenna based on metamaterials with a high gain using array antenna
Authors: Bellekhiri Abderrahim , Chahboun Noha , Laaziz Yassin , El Oualkadi Ahmed
Published: September 2022

In this paper, a symmetrical monolayer metamaterial superstrate is placed on a microstrip patch antenna resonant at 3.5 GHz. MTM metamaterial based CSRR Complementary Split Ring Resonators, constituting two rectangular rings is opposite splits on both ends, which are printed on Rogers RT 5880 type substrate with relative permittivity of 2.2, tangential loss of 0.0009, and a thickness of 0.508mm. This resonator is capable of exhibiting an ε-negative permittivity. Moving an MTM superstrate loaded with a 2 × 3 grating on a single radiating element, provides a gain increase from 4.66 dBi to 5.67 dBi was found at its operating frequency, and the radiation pattern was directional and stable over the entire frequency band. For a 4×1 antenna array loaded with MTM, the gain reaches about 9.84 dBi. the proposed antenna is suitable for 5G mobile applications.
Development of Compactness of Reconfigurable LPF/BSF Using a Simple Technique for Radar Applications
Authors: Sghir Elmahjouby
Published: September 2022

In this paper a new compact reconfigurable low pass/band stop filter using a miniature omega resonator placed in a small DGS in the ground. The reconfiguration in frequency response can be achieved with the same topology and the same dimensions by changing just the position of channel slot which connect the omega resonator to the metallic ground without any other requirements. Several advantages obtained with this structure based on the use of one omega resonator cell such as simplicity of fabrication, very low insertion loss in the pass bands, a high rejection in the stop band with a sharp transition. This filter is suited for many areas of modern communication applications and microwave technology since it shows a simple frequency reconfiguration with a several benefits such a good wide rejection of out of bands signals, high selectivity, compactness and small losses and seize, with total area of 9.08×10mm2.
The effect of tuning screws of the S-parameters of a 5G bandpass Filter
Authors: Aghanim Amina , Oulhaj Otman , Ouboudrar Ismail
Published: September 2022

In this paper, the design and simulation of a symmetrical waveguide filter are presented based on the insertion loss method. The designed WR-34 waveguide filter is operating at 28 GHz, where its dimensions are a=4.32mm and b=8.64mm, a fractional bandwidth of 2.15% a return loss level better than 16 dB, a frequency range from 22Ghz to 33 GHz. The structure is a 5th-order bandpass filter with five resonators and six symmetrical circular inductive irises. In order to optimize the frequency response, five tuning screws were added to the center of each resonator, while two other screws were positioned before the first iris and the last iris from the wave ports. The simulation model of the filter is developed in two different simulators ANSYS high-frequency Structure Simulator (HFSS) and CST Studio Suite so as to validate the obtained results and to depict the effects of tuning screws on the S-parameters of the filter while generating scenarios depending on the depth of penetration of each screw.
A GaAs Low Noise Amplifier for 2.4 GHz ISM band Applications
Authors: Ribate Mohamed , Mandry Rachid , Elabdellaoui Larbi , Benbrahim Mohammed
Published: September 2022

In this paper, a Low Noise Amplifier (LNA) operating in the Industrial Scientific and Medical (ISM) band of 2.45 GHz is proposed. The designed LNA is based on GaAs ATF21170 active device. To improve gain and matching parameters, a hybrid matching technique based on smith chart and optimization is used. The proposed biasing network as well as the stabilization circuit allow achieving a minimum noise figure with an unconditionally stability over the whole operating frequency ranging from 2.25 GHz to 2.55 GHz. Finally, some tradeoffs were done to obtain the minimum noise figure with the greatest available power gain. In terms of performances, the proposed structure shows an excellent noise figure of ~1Db.The simulated results show an excellent input/output return loss under -15 dB over the operation frequency band with an excellent small signal gain ranging between 17 dB and 15 dB. In terms of large signal performance, the proposed LNA achieves an output power of 17 dBm (52 mW) with a PAE of 22% and an output intercept IP3 around 27 dBm.
Semi-Analytical Finite Element (SAFE) method for plotting Lamb waves dispersion curves of an aluminum plate and comparison with Disperse software
Authors: Yacoubi Abdelali , Jabiri Ayoub , El Allami Mhammed
Published: September 2022

Investigation into ultrasonic Non-destructive evaluation (NDE) methods for assessing complex designs depends firmly on displaying apparatuses that calculate dispersion curves. These expectations are vital for empowering the best assessment methodologies to be distinguished and their aversions to being assessed. This study, the main purpose of this work is to do a quantitative evaluation of the SAFE technique by calculating dispersion curves (wavenumber, phase velocity, and group velocity) and comparing them to those generated by Disperse Software.
SCMA Codebook Design Based on a 16 Star-QAM with MED Maximization
Authors: Meriem Afilal , Anas Hatim , Adnane Latif , Mounir Arioua
Published: September 2022

The SCMA codebook design is based on star-QAM signalling constellations with operating several segmentations to generate the different user’s codebook while considering the MED maximization as the criterion design. In addition, we constructed the mapping matrix F using Progressive Edge Growth (PEG) algorithm which facilitate iterative decoding performance of the message passing algorithm (MPA). At the end, a comparison with similar studies is conducted on the MEDs of the designed codebooks.
Impact of Aircraft Performance and Time of the Day on Flight Arrival Delays Prediction in the United States: a Machine Learning Classification
Authors: Alla Hajar , Moumoun Lahcen , Balouki Youssef
Published: September 2022

The excessive growth of air traffic, with the limited airspace and airports capacity, results in a flight demand-capacity imbalance leading to air traffic delays. This paper explores the factors associated with delay in both microscopic and macroscopic ways. The aim is to develop a model which analyzes and predicts the occurrence of flight arrival delays using US domestic flight data for the year 2018. It will provide passengers, airlines and airport managers with reliable flight arrival schedules, and consequently reduce economic losses and enhance passengers trust. Beside database features, the proposed model is to the best of our knowledge the first attempt to predict flight arrival delays using three new features which are contributive factors to delays: Departure Time and Arrival Time of the day in which the flight was performed (Early morning, late morning, noon, afternoon, evening or night) and model of aircraft. Four Machine Learning classifiers namely Random Forest, Decision Trees, K-Nearest Neighbors and Naive Bayes were used. In order to find the best parameters of each algorithm, we implemented Grid Search technique. The performance of each classifier was compared in terms of hyperparameters tuning, classification metrics and features description. The experimental results showed that the proposed system was able to predict flight arrival delays with the best Random Forest accuracy of 0.9356 and a higher number of correctly classified flights. To prove the importance of our findings, we compared our model to that of existing literature studies.