bluuebunny/crossref_metadata_2025 huggingface dataset:
An Effective Channel Allocation Designed Using Hmdic Algorithm in Distributed Manet
Authors: R Suganya , D Ranjani , R Kanmani
Published: July 2022

The mobile ad hoc networks (MANET), the channel availability problem reaches a greater extent and it gains lot of attention in communication network. Increasing mobile usage can cause deficiency for channel allocation so that the improved channel allocation scheme is proposed to solve the availability problem. In this paper, the distributed dynamic channel allocation model is designed using hybrid memory dragonfly with imperialist competitive (HMDIC) algorithm. This technique allocates the channel to mobile hosts based on optimization logic. Without the base station infrastructure, the MANET creates a distributed network within the coverage area. In this scenario, the HMDIC optimizer technique randomly initiates their individual node to update and store its pbest value using memory dragonfly using satellite images. Then the constraint values are deployed to compute the cost function which in terms a powerful imperialist of global optimal solution is obtained at the end. In this way, the channels are allocated in efficient manner. In order to validate the performance, HMDIC based distributed dynamic channel allocation (DDCA) scheme provide promising result of assigning the available channels thereby improving the channel reuse efficiency and fractional interference.
New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis
Authors: Lv Jia-Bei , Han Ying , Wang Xin-Yan , Yuan Li-Na , Diao Jun-Rong , Fan Ya-Zhen , Luo Hai-Ning
Published: July 2022

Background: Menstrual cycle length (MCL) and ovarian response varies widely among women of childbearing age, we tried to provide AMH cutoffs for "normal" and "weakened" ovarian responses to them, which give an early warning of the onset of decreased ovarian response.Methods This was a retrospective study in women aged 21 to 35 years with MCLs of 21-35 days receiving in vitro fertilization (IVF) treatment at our hospital from October 2018 to October 2021. Intergroup variables were balanced using propensity score matching, and each case patient was matched with three control patients. A receiver operating characteristic curve was used to calculate the AMH cutoff values.Results We included 135 patients with MCLs of 21-25 days and 405 matched control patients with MCLs of 26-35 days who received IVF treatment. The case group had significantly fewer retrieved oocytes, lower AMH values and higher initial and total Gn levels during controlled ovarian hyperstimulation than the control group. The ovarian response began to decrease when AMH was < 3.5 ng/ml in the case group and < 2.7 ng/ml in the control group.Conclusion In young women with MCLs of 21-35 days, short MCL was negatively correlated with AMH values and the number of oocytes retrieved. In patients with MCLs of 21-25 days and 26-35 days, the AMH cutoff values corresponding to the onset of decreased ovarian response were 3.5 ng/ml and 2.7 ng/ml, respectively.
Determination of the timing of Bevacizumab administration in Osimertinib and Bevacizumab combination therapy
Authors: Teng Fei , Xu Ziyi , Hao Xuezhi , Yang Ke , Qiao Yingkai , Wang Qi , Wang Jing , Li Junling , Xing Puyuan
Published: July 2022

Background: In recent years, studies have suggested that EGFR-TKIs can act synergistically with vascular endothelial growth factor inhibitors. In osimertinib and bevacizumab combinatorial treatment, the timing for the addition of bevacizumab is yet to be clearly defined. Methods: From April 1, 2018, to January 1, 2021, a total of 31 patients were enrolled in this study. Osimertinib was orally administered once every day at a dose of 80 mg. There was a treatment cycle every 21 days. Bevacizumab (7.5 mg/kg) was administered by drip infusion on the first day of each cycle. Results: 31 patients included in this study.The median progression-free survival were 13.47 months (range: 7.72–19.21 months), respectively. A total of 26 patients were subjected to response analysis. Of the 26 patients, 6 (23.08%) had a partial response, 20 (72.92%) had stable disease, and none had progressive disease. The overall response rate was 23.07%. Sixteen patients had central nervous system (CNS) disease. The CNS response rate in patients with measurable and non-measurable diseases was 71%. All patients were evaluated for the toxic effects of the drugs. The average use of bevacizumab was 9.13 months (range: 3.5–13.03 months). The treatment modality of “T to A+T” was found to yield better benefits to the patients than the treatment modality of “A+T” (HR=0.165, 95% CI: 0.029–0.928, P=0.041). EGFR21 had a significantly higher risk of progression than EGFR19 (HR=6.998, 95% CI: 2.101–23.311, P=0.002). Conclusion: The treatment modality of “T to A+T” was found to be better than that of “A+T” and can prolong the time of drug resistance. Patients with EGFR19 had a better prognosis than those with EGFR21, regardless of the treatment modality.
Cancer Regulator EGFR‑ErbB4 Heterodimer is Stabilized Through Glycans at the Dimeric Interface
Authors: Motamedi Zahra , Shahsavari Mehri , Rajabi-Maham Hassan , Irani Maryam Azimzadeh
Published: July 2022

The ErbB family of tyrosine kinase receptors is composed of four homologous members, including EGFR (ErbB1/HER1), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). Since the ErbB proteins play vital roles in various developmental processes, their mutation or overexpression leads to severe abnormalities such as cancer. The general mechanism of ErbB receptors activity is binding to growth factors via their extracellular domain followed by tyrosine phosphorylation intracellularly. Yet the EGFR and ErbB4 are the only two members that keep their ligand-binding domain and the tyrosine kinase activated. In contrast, ErbB2 and ErbB3 are incapable of keeping their ligand-binding and kinase domains activated, respectively. Active ErbB receptors form homo and heterodimers by binding of two similar or different family members together, respectively. Ligands and intracellular pathways that could be activated through heterodimerization are more diverse compared to homodimers. Moreover, it is known that N-glycosylation is critical for stabilizing and activating the ErbB receptors. In this study, atomistic molecular dynamics simulations were used on one of the most potentiated ErbB heterodimers (EGFR-ErbB4) in the glycosylated and unglycosylated states. It was shown that the EGFR-ErbB4 heterodimer is highly stabilized by glycosylation. The increased stability is most significant at the dimeric interfaces. Regulated by packing of three glycans attached to EGFR (Asn337) and ErbB4 (Asn333, Asn523) at the dimeric interface. Finally, it is proposed that heterodimerization is the persistent key player of the ErbB receptors activation. Thus, targeting the heterodimers in future therapeutic designs could be a promising approach against drug resistance ErbB positive cancers.
Surface Irrigation Potential Assessment Using GIS and HBV Model: A Case Study at Fetam Watershed, Upper Blue Nile, Ethiopia
Authors: Desalegn Hunegnaw , Damtew Banchiamlak , Mulu Arega
Published: July 2022

Small-scale rainfed small-holder farming accounts for about 85% of Ethiopia's food supply. As a result, the increase in crop production does not correspond to the increase in the country's population. As a result, in order to alleviate this problem, irrigation must be used to supplement rainfall farming. It is critical to do this assessment of potential water resources and suitable terrain for irrigation in every section of the country. As a result, this study began to assess the Fetam watershed's irrigate and land resource potential for irrigation development. Irrigation suitability problems like as slope, soil type, land usage land cover, and distances as a water source are used in justification to designate potentially irrigable earth. Data from several government agencies was obtained and utilized, including hydrological, meteorological, Digital elevation model, soil drainage, soil depth, soil texture, and agro-climatic map data. In addition, satellite pictures were utilized in this study. Irrigation appropriateness was assessed using a geographic information system with multi-criteria decision evaluations, and the HBV and CROPWAT 8 models were utilized to determine the likelihood of water resources and irrigation water requirements. The coefficient of determination (R2), Nash Sutcliffe models efficiency (NSE), and Percent Biases (PBIAS) of the performance evaluation statistics were 0.54, 0.51, + 15 and 0.69, 0.67, -15, respectively, indicating that the HBV model performance is satisfactory. In general, there are 12583.47 ha of appropriate lands used for irrigation inside research areas.
Increase in grain protein and gluten contents of bread wheat by the introgression of a T. timopheevii segment into chromosome 2A
Authors: Shchukina L.V. , Simonov A.V. , Demenkova M.A. , Klykov A.G. , Shamanin V.P. , Pozherukova V.E. , Lepekhov S.B. , Chebatareva M.V. , Petin V.A. , Börner A. , Pshenichnikova Tatyana Alexeevna
Published: July 2022

End use and value of harvested bread wheat grain is determined by its protein and gluten content. Therefore, the stable manifestation of this trait in a cultivar is an important breeding goal. According to some reports, the tetraploid species T. timopheevii is characteristic for a high protein and gluten contents in grain. However, there are no examples of transfer of genes for these traits from this species. The aim of this study was to transfer chromosome 2A with an introgression from T. timopheevii from an experimental line (line 821) to bread wheat cultivar Saratovskaya 29 (S29) and to show its association with increased protein and gluten contents in grain. The chromosome 2A with introgression from T. timopheevii was transferred to cv. S29 using a monosomic line and its integrity was checked using 14 molecular markers. The obtained single chromosome substitution line S29 (821 2A) was grown in 5 different geographical locations: Novosibirsk, Omsk, Barnaul, Ussuriysk and Gatersleben, as well as in a greenhouse. It was found that under all conditions, protein and gluten contents in grain of line S29 (821 2A) was significantly higher by 1–2% and 3–4%, respectively, compared to the parental cultivar. In most cases this introgression did not reduce grain yield and retained thousand grain weight. The line had high rheological properties of dough comparable to the high-quality cv. S29. It has been suggested that the new genetic factor may belong to the homoeoallelic series of gene Gpc-2 for high grain protein content.
Simultaneous Cr (VI) reduction and Diazinon oxidation with organometallic sludge formation under UV irradiation: Kinetics, degradation pathways and mechanism
Authors: Karimi Pouria , Azarpira Hossein , Rasolevandi Tayebeh , Sarkhosh Maryam , Azizi Shohreh , Mohseni Seyed Mohsen , Sadani Mohsen
Published: July 2022

In this study, simultaneous removal of an organic matter (Diazinon -DIZ) and a inorganic substance (Chromium-Cr) was used. Broken down of organic matter by UV irradiation and produces various radicals, including sulfides, carboxyl, hydroxyl, hydrated electrons, and various organic radicals that are highly reactive and help us to precipitation inorganic substance (Cr). The optimal condition was 30:1 DIZ: Cr Molar ratio, pH 9, about 100% and 82.3% of DIZ and Cr were obtained in 30 minutes. Cr deposition was very slow at first. After the destruction of the DIZ structure, Cr deposition began and various types of sludge with disturbed properties were formed. These sledges were analyzed by Ftir analysis and showed green sludge could be Chromium (III) Hydroxide, brown sludge due to Chromium (III) Hydroxide, Tiny green crystals from Chromium (III) oxide, red brick from Chromium (II) acetate Chromium trioxide or as well as Black sludge caused by Chromium oxide were identified. in UV/DIZ/Cr process, k obs, r obs, range obtained 0.33 − 0.15, 16.8–23.4 $ with the both Cr and DIZ concentration increased from 50 to 150 mg L− 1. Also, E EO for Cr precipitation were 24.65 to 5.74 and for DIZ 12.54 to 4.73 (kwh m− 3). Depending on the amount of energy consumption, TCS were 37.19 to 10.47 for Cr precipitation and 4.46 to 1.25 $. It is important to note that when both pollutants are exposed to ultraviolet light, more energy and cost are generally required from UV/DIZ process and less than of UV/Cr process. But it should be noted that in fact 50 mg L− 1 of chromium and 50 mg L− 1 of DIZ are being removed at the same time. In UV/DIZ and UV/Cr processes that are exposed to ultraviolet radiation alone, only one of them is removed. Also, when these two pollutants are being removed at the same time, the total amount of energy is much less than the total energy consumption of the pollutants one by one.
Research on Biochemical Solidification and Microstructure Characteristics of Bauxite Tailings Clay
Authors: Jiang Jie , Wang Shufei , ou xiaoduo , Su Jian , Mo Peng
Published: July 2022

Microbially induced carbonate precipitation (MICP) has an excellent consolidation effect, but the application in tailings clay is less at present. This work researched the quicklime and microbial co-curing technology (biochemical consolidation technology) to explore the consolidation characteristics and pores microstructure of tailings clay. The results show that: The optimum shear strength and compressibility of solidified soil after biochemical treatment were 30 kPa and 0.19 MPa− 1, which increased by 112.77% and decreased by 38.71% compared with quicklime treatment. The fractal dimension of surface pores was reduced after biochemical treatment and the minimum was 1.136 when the quicklime was 105g. The minimum surface porosity was 4.26%, which was reduced by 76.17% compared with quicklime treatment. The pores shape of solidified soil after biochemical treatment is more regular, and the circularity reached 65.93% in the range of 0.9-1, which is higher than 39.23% of quicklime treatment. The biochemical treatment can fill the narrow pores and make the large pore volume above 50 nm translate into a small volume. The hydrate reaction products could provide a suitable growth environment for bacteria, and the quicklime also as the source of calcium participates in the biochemical reaction. The optimum quicklime content is 105g, and excessive quicklime can increase solidified soil expansion and crack, and a high pH will inhibit bacterial activity. This work could provide a new approach to tailings reservoir stabilization and ensure the effectiveness of bauxite tailings consolidation.
Characterization of a buried quarry by historical analysis of satellite images integrated with electrical resistivity tomography, East Cairo area, Egypt
Authors: Lethy Ahmed , Massoud Usama , Mesbah Hany , Abbas Abbas M. , Said Said Mohamed
Published: July 2022

East Cairo is characterized by abundant quarries that have been used as landfill sites for solid waste. These sites have become part of the urban sprawl of New Cairo, and their detection became difficult from the ground surface. In this study, analysis of multi-temporal high-resolution satellite images and electrical resistivity tomography (ERT) data were used to detect and delineate a buried landfill site located near the Ring Road, East Cairo, Egypt. Analysis of changes detected on the satellite images revealed that the study site was a WNW-oriented Quarry until 2005 and then randomly filled with heterogeneous solid materials. ERT survey was planned based on the result of change detection. On the plan view, the ERT measurements have outlined the electrically conductive zones which are occupied by filling material and distinguished them from the resistive zones that symbolize the natural soil areas. By assimilation of the satellite images and the ERT results, two distinguished geoelectrical units could be perceived; Unit-1 (the upper unit) is characterized by low to moderate resistivity values being the solid waste materials, while Unit-2 (the lower unit) is characterized by high resistivity values that characterize the original soil (bedrock). The closely spaced grid of ERT profiles and the detailed topographic map helped in mapping and delineating the contact between the bedrock and the filling materials. Several parameters could be addressed and were used for characterizing the unit of interest (Unit 1) including ground surface elevation, depth of the lower boundary of Unit-1, and thickness variation of this unit across the investigated site.
A Metal-Catalyzed Functional Group Metathesis Approach to the Carbon Isotope Labeling of Carboxylic Acids
Authors: Kinney R. Garrison , Zgheib José , Lagueux-Tremblay Pierre-Louis , Yang Haifeng , Gauthier Donald , Arndtsen Bruce
Published: July 2022

The distribution, metabolism and ultimate fate of molecules within the body is central to the activity of pharmaceuticals. However, the introduction of radioisotopes into the metabolically stable carbon sites on drugs required to probe these features presents a significant hurdle, since it typically requires synthesis with toxic, radioactive gases such as 14CO2 and 14CO. Here, we describe a straightforward alternative approach to directly carbon-label carboxylic acid-containing pharmaceuticals: via a metal catalyzed functional group exchange reaction. This provides a general route to 14C-labeled carboxylic acid-containing drugs without radioactive gases, in one pot, and using an easily available and handled carboxylic acid 14C-source. To enable this process, a new class of functional group metathesis of carbon-carbon covalent bonds in acid chloride functionalities is developed that exploits the ability of earth abundant nickel catalysts to both reversibly activate carbon-chloride bonds and exchange functionalities between organic molecules. The applicability of this system to drug development is illustrated by the direct incorporation of 14C- or 13C-label into an unprecedented array of complex aryl, alkyl, vinyl and heterocyclic carboxylic acid drugs or drug candidates without gases or special apparatus, at simply ambient conditions, and without loss of the radiolabel.
Effects of width-height ratio and roof-floor strength on the mechanical characteristics of cemented gangue backfill pier-column
Authors: Ran Hongyu , Elchalakani Mohamed , Guo Yuxia , Feng Guorui , Yang Bo
Published: July 2022

Cemented gangue backfill pier-column (CGBP) is the essential supporting component of the goaf in partial backfill mining or constructional backfill mining for controlling the surface subsidence of coal mining. The height of CGBP has been determined by the thickness of the coal seam, and thus the width-height ratio and roof-floor strength directly affect the bearing capacity of CGBP under axial compression. Herein the effect of width-height ratio (1/3 − 1/1) on the mechanical characteristics of CGBP with different curing ages under uniaxial compressive was system studied through experiment, and the damage process was analyzed by ultrasonic equipment and DIC. Based on the experimental results and discrete element theory, a three-phase numerical model for CGBP was established, which considered the real aggregate shape and distribution and the mechanical characteristics of each phase. Then, the effects of the end friction coefficient and the strength ratio of roof-CGBP-floor combination on the strength and failure characteristics of CGBP (large width-height ratio: 1/1–4/1) were investigated. The results show that: CGBP shows the width-height ratio effect obviously and the strength and ductility increase with the increase of the width-height ratio, and the width-height ratio effect increases with the increase of curing age and strength ratio. The end friction constraint is the main reason for the width-height ratio effect, and the higher the friction coefficient is, the larger the width-height ratio effect shows, and the width-height ratio effect disappears without end friction constraint. The increase of the width-height ratio of CGBP and the strength ratio of the roof-CGBP-floor combination increases the strength of the combination. Whether the strength of the combination is greater than that of CGBP may have a roof-floor strength threshold or a strength ratio threshold, which are between 31.44–54.11 MPa and 3.75–6.44, respectively. When the strength of the roof and floor is different, the strength of the combination is mainly controlled by the weak carrier and increases with the increase of the strength of the weak carrier. The peak strain energy of CGBP and combination increases with the increase of end friction coefficient, width-height ratio, and strength of roof and floor.
Zein protein obtained from maize as a novel biodegradable membrane material for oxygen/nitrogen separation: membrane fabrication and characterization
Authors: Dirin Amirreza Malekzadeh , Saljoughi Ehsan , Kiani Shirin , Mousavi Seyed Mahmoud
Published: July 2022

In this study, biodegradable zein protein obtained from maize was used as a novel material to prepare a membrane for oxygen/nitrogen separation. Scanning electron microscopy (SEM), thermogravimetric analysis (TGA), tensile test, X-ray diffraction (XRD) spectroscopy, differential scanning calorimetry (DSC), biodegradability test, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy were conducted for characterizing the zein membrane, and membrane properties was compared with that of the polymeric membranes reported in the literature. The developed zein membrane showed a significantly high thermal stability. The mechanical properties of the zein membrane were higher or comparable to those of the previously reported dense membranes. In addition, biodegradation in compost was significantly higher than the other membranes reported in the literature. The developed zein membrane provided a significantly high oxygen/nitrogen selectivity at 2 bar, which was superior to most of the previously reported data on the neat biodegradable polymers with dense structure. The permeability of oxygen and nitrogen at 2 bar was 0.67 and 0.12 barrer, respectively, which brought about the selectivity of 5.45 for oxygen/nitrogen separation.
Determinants of schistosoma mansoni transmission in hotspots at the late stage of elimination in Egypt
Authors: Ghazy Ramy M. , Ellakany Walid , Badr Mai M. , Taktak Nehad E.M. , Elhadad Heba , Abdo Sarah M. , Hagag Ayat , Hussein Abdel Rahman , Tahoun Mohamed M.
Published: July 2022

Purpose To investigate the role of human practices and environmental factors in maintaining the transmission chain. Study Design a Cross-section study was conducted between July and November 2019 to determine the effect of malacological and environmental factors on the prevalence of Schistosoma mansoni (S.mansoni) in Kafr El-Sheikh (KES). Methods 2259 fecal samples were collected from 861recruitted children aged 6-15 years. Simultaneously, water and snail samples were collected from watercourses surrounding their houses. Results Prevalence of Schistosoma mansoni infection was significantly higher during summer than during fall (19.1% Vs 7.2%, respectively, p <0.01).The intensity of infection (light, moderate, and heavy) during summer versus fall was (93.55% vs 89.38%, 6.45% vs 8.85, and 0.00% vs 1.77%), P<0.05. Higher prevalence of human infection was identified among males than females (OR=1.63, CI: 1.10-2-40), children aged 11-15 years than among counterparts aged 6-10 years, (OR=2.96), and if mothers were of low educational level (OR=2.83, CI: 1.72-5.06). The main identified risk factors were contacting the main body of water-canal for either washing clothes, land irrigation, collecting waters, bathing, or garbage disposal (P<0.05). The count of collected Biomphalaria alexandrina (B. alexandrina) was statistically different across different seasons (p<0.01) in line with a similar significant difference in water temperature, salinity, turbidity, total coliforms (TC) concentration, depth, velocity, and water level (p<0.01). The presence of grasses and duckweeds had a significant association with snail infection (p = 0.00l). Water depth, pH, temperature, and total dissolved solids (TDS) significantly affected the snail count. Conclusions The persistence of the transmission cycle is mainly affected by the socioeconomic status, and the adopted risky behaviors of the local citizen. Over and above, environmental factors enhance snail survival and catching the cercarial infection.
Predictive-Adaptive Sliding Mode Control Method for Reluctance Actuator Maglev System
Authors: Xu Yunlang , Ding Chenyang , Su Xinyi , Li Zhi , Yang Xiaofeng
Published: July 2022

The control performance of reluctance actuator maglev system is seriously affected by inherent nonlinearities (e.g., hysteresis, eddy current, flux leakage, etc.) and external disturbances. To this end, this paper proposes an enhanced unknown system dynamics estimator (USDE)-based sliding mode control (USDE-SMC) method by a novel predictive-adaptive switching (PAS) controller (USDE-SMC-PAS). First, a USDE is incorporated into SMC to compensate for the uncertainties; Second, an adaptive switching (AS) controller is used to reduce chattering; Finally, the switching controller is modified by PAS to enhance the dynamic response ability and disturbance rejection ability with reduced chattering. In the PAS controller, the switching gain comprises a filtered estimate error part and a residual part, which are obtained by a first-order filter and an adaptive law, respectively. Consequently, the strong disturbance compensation ability, high levitation accuracy, high dynamic response, and reduced chattering property can be achieved simultaneously. The stabilities of USDE-SMC, USDE-SMC with an AS controller (USDE-SMC-AS), and USDE-SMC-PAS in the closed-loop system are analyzed by the Lyapunov theorem. Simulations and experiments are provided to validate the effectiveness and superior performance of the proposed method.
Major Complications and Mortality After Ventral Hernia Repair:An Eleven-Year Swedish Nationwide Cohort Study
Authors: Lindmark Mikael , löwenmark thyra , strigard karin , gunnarsson ulf
Published: July 2022

Background and aims:
Ventral hernia repair is one of the most common surgical procedures performed worldwide. Despite the large volume, consensus is lacking regarding indications for repair or choice of surgical method used for reconstruction. The aim of this study was to explore the risk for major complications and mortality in ventral hernia repair using data from a nationwide patient register.
Method:
Patient data of individuals over 18 years of age who had a ventral hernia procedure between 2004 and 2014 were retrieved from the Patient Register kept by the Swedish National Board of Health and Welfare. After exclusion of patients with concomitant bowel surgery, 45 676 primary surgical admissions were included. Procedures were dichotomised into laparoscopic and open surgery, and stratified for primary and incisional hernias.
Results:
A total of 45 676 admissions were analysed. The material comprised 36% (16 670) incisional hernias and 64% (29 006) primary hernias. Women had a higher risk for reoperation during index admission after primary hernia repair (OR 1,84 (1,29 − 2,62)). Forty-three patients died of complications within 30 days of index surgery. Patients aged 80 years and older had a 2.5 times higher risk for a complication leading to reoperation, and a 12-fold higher mortality risk than patients aged 70–79 years.
Conclusion:
Age is the dominant mortality risk factor in ventral hernia repair. Laparoscopic surgery was associated with a lower risk for reoperation during index admission. Reoperation seems to be a valid outcome variable, while registration of complications is generally poor in this type of cohort.
Minocycline attenuates lipopolysaccharide-induced locomotor deficit and anxiety-like behavior via upregulation of the BDNF/CREB protein expression in the rat medial prefrontal cortex (mPFC)
Authors: Qaid Entesar Yaseen Abdo , Abdullah Zuraidah , Zakaria Rahimah , Long Idris
Published: July 2022

Introduction: Neuroinflammation following lipopolysaccharide (LPS) administration induces locomotor deficit and anxiety-like behavior. In this study, minocycline was compared to memantine, the NMDA receptor antagonist, for its effects on LPS-induced locomotor deficit and anxiety-like behavior in rats. Methodology: Adult male Sprague Dawley rats were administered either two different doses of minocycline (25 or 50 mg/kg/day, i.p.) or 10 mg/kg/day of memantine (i.p.) for 14 days four days prior to LPS (5 mg/kg, i.p.) injection. The locomotor activity and anxiety-like behavior were assessed using the open field test (OFT). The phosphorylated tau protein level was measured using ELISA while the expression and density of brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) protein in the medial prefrontal cortex (mPFC) were measured using immunohistochemistry and western blot, respectively. Results: In the mPFC, minocycline treatment reduced the locomotor deficit and anxiety-like behavior, reduced phosphorylated tau protein level, and upregulated BDNF/CREB protein expression comparable to memantine, with the higher dose of minocycline having better benefits. Conclusion: Minocycline treatment attenuated LPS-induced locomotor deficit and anxiety-like behavior in rats, possibly via a decrease in phosphorylated tau protein levels and an increase in the expression of the BDNF/CREB proteins.
Simulation of Long-period Ground motion: verification and sensitivity study on the 2013 Lushan Mw6.6 earthquake
Authors: Ji Zhiwei , Li Zongchao , Chen Xueliang , Sun Jize , Yu Houyun , Li Tiefei , Li Qi , Huang Ting , Zhang Bo
Published: July 2022

The eastern margin of the Tibetan plateau is adjacent to the Sichuan Basin, which is one of the areas with frequent large earthquakes. The important structures such as bridges and lifeline projects in the region is easily affected by long-period ground motion. It is significant to evaluate the long-period ground motion characteristics of destructive earthquakes in this region. In the first part of this study, the long-period ground motions of the 2013 Lushan Mw6.6 earthquake is simulated using the finite difference method, and three one-dimensional crustal velocity structures are used. We first compared the observed and simulated long-period ground motions of three models in terms of velocity waveforms, pseudo-velocity response spectra, and displacement response spectrum. We then analyzed the residuals of velocity waveforms between the amplitude of simulated and observed. In the second part of this study, the source parameters of rupture velocity, rise time, and stress drop are selected for sensitivity analysis. The results show that it is feasible to use the one-dimensional crustal velocity model of the Sichuan basin to analyze the long-period ground motion of the 2013 Lushan Mw6.6 earthquake. The amplitude of long-period ground motion decreases with the increase of rise time. The amplitude of long-period ground motion and the change of stress drop shows a linear relationship as a whole. The rupture velocity exceeds the shear wave velocity making the PGV distribution of long-period ground motion show spatial variability. In predicting scenario earthquakes, the uncertainty of parameters should be carefully considered. When some parameters are more sensitive to the long-period ground motion, more weights need to be given to these parameters to obtain reliable ground motion results.
The Spatiotemporal Variations of Total Column Ozone Concentration over Ethiopia
Authors: Alemu Abebaw Bizuneh , Seid Abdu Mohammed , Yeshita Baylie Damtie , Raju U. Jaya Prakash
Published: July 2022

We have studied the spatiotemporal characteristics of ozone concentration over Ethiopia using Ozone Mapper and Profiling Suite (OMPS) Satellite measurements. Daily total column ozone measurements of 252 data points with spatial resolution 1 ◦ × 1 ◦ for the study area and its surrounding during the period 2012 – 2020 have been analyzed. We investigated the spatial variation over the region from longitudinal and latitudinal bands separately by assessing existence of mean difference among different bands using multicomparison analysis of variance technique and determined the clusters in the region. For the temporal variability, we employed timeseries analysis and decomposed the ozone concentration series for each class into seasonal, trend and residual components. We have found that the total column ozone concentration has a maximum value of 301DU during summer on August 18, 2013 and a minimum value of 216DU during winter on February 03, 2013 over the study period. The 95% confidence level of the overall mean of total column ozone concentration during the study period was found to be (261 . 28 ± 4 . 2)DU . Our spatial data analysis revealed that the spatial distribution of ozone over Ethiopia can be classified into three major regions: Southern Cluster (4 . 5 ◦ N − 8 . 5 ◦ N & 32 . 5 ◦ E − 47 . 5 ◦ E ) , North–Eastern Cluster (9 . 5 ◦ N to 14 . 5 ◦ N & 41 . 5 ◦ E − 47 . 5 ◦ E ) and North–Western Cluster (9 . 5 ◦ N − 14 . 5 ◦ N & 32 . 5 ◦ E − 40 . 5 ◦ E ). We also checked the degree of determination among bands in same cluster to see if the concentration of ozone in one band can be explained by the concentration in a another band for each cluster and confirmed the reliability of the classification. From the timeseries analysis, we made an assessment of spectral periodogram for each cluster and obtained a single Fourier power peak with frequency of f = 0 . 002768 Hz , which indicated that the ozone concentration has an annual cyclic behavior in the region. A truncated Fourier series fit is made to determine the annual seasonal component. The non-parametric Mann-Kendall’s trend test with a 95% confidence level of significant indicated a decreasing linear trend with a depletion rate of 0.77 DU/yr, 0.73 DU/yr, and 0.43 DU/yr over North–Western, North–Eastern & Southern clusters respectively. The analysis of residuals result for each cluster indicated that the standardized residuals are normally distributed and white noises. Hence, the model considered is reliable.
Tetrahydroquinolinone derivatives exert antiproliferative effect on colorectal and lung cancer cells through apoptosis induction
Authors: Ryczkowska Małgorzata , Maciejewska Natalia , Olszewski Mateusz , Witkowska Milena , Makowiec Sławomir
Published: July 2022

The anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new anticancer drugs. In this work, we designed a brief synthetic pathway and obtained a series of novel 8-phenyltetrahydroquinolinone derivatives functionalized with benzyl-type moieties at position 3. The compounds were synthesized via classical reactions such as nucleophilic substitution, solvent lysis, and condensation. Biological evaluation revealed that 3-(1-naphthylmethyl)-4-phenyl-5,6,7,8-tetrahydro-1H-quinolin-2-one (4a) exhibited potent cytotoxicity toward colon (HTC-116) and lung (A549) cancer cell lines. Analysis of the mechanism of action of compounds showed that compound 4a induced cell cycle arrest at the sub-G1 phase, leading to apoptotic cell death via intrinsic and extrinsic pathways. Taken together, the findings of the study suggest that tetrahydroquinolinone derivatives bearing a carbonyl group at position 2 could be potential lead compounds to develop anticancer agents for the treatment of colon and lung cancers.
Impact of Power Ramp Event on Photovoltaic System Voltage Quality Under Different Weather Conditions and Operating Powers
Authors: boulahchiche saliha , ARAB Amor HADJ , HADDAD Salim , BOUTELHIG Azzedine , BOUCHAKOUR Salim , BENDAAS Ismail , REZAGUI Abdelhak
Published: July 2022

This paper presents an experimental voltage quality analysis affected by passing clouds based on results attained from monitoring a 9.5-kWp photovoltaic grid connected. This system is composed of three 3.2 kWp subsystems installed on the flat roof of the Renewable Energy Development Institute (CDER) in Algeria. In this paper we analyzed and evaluated Short-term and long-term voltage flicker indexes (Pst,Plt), power ramp event on voltage quality, harmonics caused by inverter and by the loads connected to the PCC, and very short voltage variation (VSV). The power quality parameters at the inverter output side have been measured using CA8335 power quality analyzer. The results show that the change in the density of the passing clouds has a linear relationship with the change in the intensity of the ramp event on the power generated by the PVS. Moreover, in the case of a bidirectional electrical network and with the presence of non-linear loads, the flicker recorded has exceeded the legal limits, due the second-order harmonics effects generated by non-linear loads and the level impedances at the grid and the PV system connection point. The concluded results obtained can be an additional profit of for the electricity distribution networks in Algeria, upon in the light of the diffusion of promoting photovoltaic systems.
circPLIN2 promotes clear cell renal cell carcinoma progression via the miR-199a-3p/ZEB1 pathway
Authors: Zhao Bin , Huang Cong , Pan Jie , Hu Hao , Liu Xiaojuan , Zhang Kaoyuan , Zhou Fenli , Shi Xin , Wu Jun , Yu Bo , Chen Xiaofan , Zhang Wei
Published: July 2022

Recent evidence has indicated that circular RNAs (circRNAs), as a novel type of regulatory RNA, play important roles in the development and progression of various cancers. However, the potential regulatory roles and molecular mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain largely unclear. Herein, we explored the expression profiles of circRNAs in 10 paired samples of RCC (including cancer tissues and surrounding tissues) from the Gene Expression Omnibus (GEO) datasets GSE124453 and GSE108735. We initially identified hsa_circ_0086457, designated circPLIN2, which was derived from exons 4 to 5 of the PLIN2 gene. circPLIN2 was significantly upregulated in ccRCC cells and tissues, and its overexpression was correlated with higher clinical stage and worse prognosis in ccRCC patients. We observed that circPLIN2 was preferentially located in the cytoplasm and had more stability than its linear counterpart PLIN2. Moreover, gain- and loss-of-function assays demonstrated that elevated circPLIN2 promoted ccRCC cell proliferation, migration and invasion in vitro and ccRCC tumor growth in vivo. Mechanistically, circPLIN2 competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1, which ultimately resulted in tumorigenesis and progression of ccRCC. Collectively, our results suggest that circPLIN2 may serve as a promising diagnostic and prognostic biomarker as well as a potential therapeutic target for ccRCC patients.
A Relay Selection Algorithm Based on User Trust Degree for D2D Communications
Authors: Liu Haoran , Li Xiaobin
Published: July 2022

The emergence of 5G has promoted the rapid development of the Internet of Things(IOT), the dramatic increasing of mobile equipment has led to the increasing shortage of spectrum resources, D2D(Device-to-Device) communication technology is widely concerned for its ability to improve the utilization of spectrum resources. In order to expand the communication scope, relay nodes are introduced into D2D communications, as the third party of D2D relay communication, the quality of relay nodes directly affects the quality of communication process. In order to make more users willing to participate in relay communication, social relationship is introduced into D2D relay communication, However, as an explicit relationship between people, the function of social relationship in D2D communication is limited by the mobility of users and the variability of communication scenarios. In order to find a more reliable relay node and upgrade the connection success rate of D2D relay communication, implicit social relationship between the users need to be mined. Aiming at that, user trust degree (UTD) is established in this paper. By combining the explicit relationship which is called the social connectivity degree with the implicit social relationship called the interest similarity degree, and considering the user’s movement, a relay selection algorithm is presented to help sender find a relay node with a deeper user trust, which can increase the user’s willingness to participate in D2D relay communication and upgrade the success rate of communication connection, so this algorithm can ensure the security of the relay node and can improve the throughput performance. Simulation results show that this algorithm can increase the success rate of connection, improve the overall throughput of the system and improve the user's communication experience.
Urinary soluble CD163: a non-invasive biomarker to monitor lupus nephritis
Authors: Toumi Eya , Jourde-Chiche Noémie , Tailliar Maxence , Mezouar Soraya , Bouamri Afaf , Bertin Daniel , Militello Muriel , Penaranda Guillaume , Plauzolles Anne , Halfon Philippe , Mege Jean-Louis , Bardin Nathalie
Published: July 2022

Due to the role of macrophages in glomerular inflammation, macrophage surface molecules such as CD163 and CD11b represent attractive biomarkers for monitoring Lupus Nephritis (LN). We hypothesize that their urinary levels may reflect kidney disease activity. Here, we first analyzed the levels of urinary soluble CD163 (U-sCD163) and CD11b (U-sCD11b) in a cohort of 40 patients with LN including 23 with active disease. U-sCD163 levels were significantly elevated in active LN and correlated with the renal activity score, in contrast to U-sCD11b. Then, we developed the pristane induced LN mouse model to analyze, in a longitudinal way, the evolution of U-sCD163 levels according to the glomerular inflammation progression and response to treatment. We showed an increase of U-sCD163 levels associated with glomerular immune-complex deposits on mouse kidney biopsies at an early stage of the disease and a correlation with inflammatory markers including interferon-α, C-reactive protein and tumor necrosis factor-α. In addition, we showed that U-sCD163 levels decreased following efficient hydroxychloroquine treatment. Altogether our results led us to conclude that U-sCD163 represent a non-invasive biomarker for LN reflecting glomerular inflammation. Although prospective study in patients with LN, active or not, are necessary, U-sCD163 could be proposed to monitor response to treatment.
Extrauterine growth restriction in very low birth weight infants according to different growth charts: a retrospective 10 years observational study
Authors: Starc Meta , Giangreco Manuela , Centomo Giacomo , Travan Laura , Bua Jenny
Published: July 2022

Background
Extrauterine growth restriction (EUGR) is common among very low birth weight (VLBW) infants and associated with poor neurodevelopmental outcomes. Prevalence of EUGR is a basic indicator of ‘nutritional care’ and an important health outcome measure. There are two types of EUGR definitions (cross-sectional and longitudinal) and many growth charts for monitoring postnatal growth. Aims of our study were 1) to compare the rate of small for gestational rate (SGA) and EUGR in a population of VLBW infants, both according to different growth charts (Fenton, INeS charts and Intergrowth-21) and according to different definitions; 2) to identify risk factors for EUGR.
Methods
this is a single centre retrospective observational study, including all VLBW infants born between 1st of January 2009 and 31st of December 2018. Anthropometric measures were obtained at birth and at discharge and presented as z-scores according to three growth charts (Fenton, INeS charts, Intergrowth-21). Maternal, clinical and nutritional data were retrieved from clinical records.
Results
228 VLBW were included. Percentage of SGA did not change significantly according to the three different growth charts (Fenton 22.4%, INeS charts 22.8%, Intergrowth 28.2%, p 0.27). Prevalence of EUGR was significatively higher when INeS and Fenton charts were used, compared to Intergrowth charts regardless of EUGR-definition (cross sectional-EUGR: Fenton 33.5%, INeS charts 40.9%, Intergrowth-21 23.8%, p 0.001; longitudinal-EUGR (loss of 1SDS): Fenton 15%, INeS charts 20.4%, Intergrowth 4%, p < 0.001). In our population late-onset-sepsis increased the risk of longitudinal EUGR (OR: 2.69, 95%CI: 0.79–9.17), similarly as a longer time to reach 100 ml/kg of feeds (OR: 1.12, 95%CI: 0.97–1.29). On the contrary, preeclampsia was a protective factor for longitudinal EUGR.
Conclusions
We confirmed a wide variability of EUGR rates when using different charts and definitions, highlighting that Intergrowth-21 charts identify less EUGR when compared to INeS and Fenton charts. Standardized criteria for defining EUGR are warranted in order to facilitate comparisons between studies and to improve the nutritional management of VLBW infants.
SARS-CoV-2 antibody seroprevalence in Togo, May-June 2021: a cross-sectional, nationally representative, age-stratified serosurvey
Authors: Konu Yao Rodion , Condé Siaka , Gbeasor-Komlanvi Fifonsi A. , Sadio Arnorld Junior , Tchankoni Martin Kouame , Anani Joel , Bitty-Anderson Alexandra , Mirindi Bismwa Ruhana , Diallo Fatoumata Binta Tidiane , Mijiyawa Moustafa , Dagnra Anoumou Claver , Ekouevi Didier Koumavi
Published: July 2022

Background: The extent of SARS-CoV-2 circulation in African countries is still unclear. seroprevalence studies are a common approach to epidemiological surveillance, allowing estimation of the proportion of people who have had contact with the virus. We aimed at estimating the seroprevalence of anti-SARS-CoV-2 antibodies and associated factors in Togo at the national level in 2021 according to age groups, gender, and place of residence (rural or urban).Methods: From 15 May to 31 June 2021, we conducted a nationally representative cross-sectional serological survey in 12 health districts (two districts per health region) in the >5 years old population in Togo. The Wantai SARS-CoV-2 total antibody assay S protein receptor-binding domain-based ELISA (Wantai Biological Pharmacy Enterprise Co.; Beijing, China) was used to determine the presence of SARS-CoV-2 total antibodies in plasma. Crude and weighted seroprevalences were calculated. Finally, logistic regression models were performed in order to describe factors associated. Results: Of the 7593 participants, the overall weighted and adjusted seroprevalence of total anti-SARS-CoV-2 antibodies was 65.5% (CI95%: 18.9 - 21.1). Urban dwellers, young adults (30-49 years) and vaccinated individuals were significantly more likely to be seropositive.Conclusion: The high seroprevalence we observed is consistent with observations across West Africa. Quantification of the level of immunity in the population is needed to know how close we are to herd immunity. In the meantime, vaccination against COVID-19 remains necessary.