bluuebunny/crossref_metadata_2025 huggingface dataset:
Postrelease Performance of Acclimated and Directly Released Hatchery Summer Steelhead into Oregon Tributaries of the Snake River
Authors: Clarke Lance R. , Flesher Michael W. , Whitesel Timothy A. , Vonderohe Gary R. , Carmichael Richard W.
Published: November 2010

In a study using 14 paired-release groups over 10 release years, we compared the performance of hatchery summer steelhead Oncorhynchus mykiss that were acclimated as smolts (AC) for 16–57 d before release into ponds supplied with ambient stream water with that of fish trucked from the hatchery and directly released (DR) into Spring, Deer, and Little Sheep creeks in northeastern Oregon. After releasing the fish into streams, we monitored out-migration travel times and survival to Lower Granite Dam (LGD) on the Snake River using freeze brand marks or implanted passive integrated transponder tags in a subsample of each release group. Across all release groups, travel time was significantly slower for AC fish (34.7 d) than for DR fish (31.8 d), though there was no significant difference in survival probability to LGD. We used recoveries of coded wire tags to estimate smolt-to-adult survival (SAS) and a stray rate index (SRI) for the AC and DR strategies. Across all release groups, SAS was 33% higher and SRI 42% lower for AC steelhead. At each release site acclimation increased average SAS by at least 11% and decreased SRI by at least 16.5%. We found a significant, negative linear relationship between travel time to LGD and SAS; however, there was no significant relationship between survival to LGD and SAS, which implies that judgments about the success or failure of a novel rearing or release strategy should not be made based on out-migration survival. Acclimating juvenile steelhead produced significantly higher SAS and lower SRI in the hatchery program we evaluated; however, our results are not consistent with those of other steelhead acclimation studies.
Stiff sedimentary clays: geological origins and engineering properties
Authors: CHANDLER R.J.
Published: October 2010

This Keynote Paper† summarises and extends earlier work on the characterisation of clays, with particular reference to stiff sedimentary clays. Examples of clay characterisation are given that include the various main geological events, from sedimentation to erosion and weathering, and other phenomena such as diagenesis and brecciation. The examples demonstrate the value of plotting basic data, such as the current stress state and undrained strength, in terms of the void index. These three parameters permit an immediate, simple categorisation, in terms of geological history, of sedimentary clays. Further examples illustrate the engineering consequences of weathering of stiff clays, and the associated phenomenon of brecciation produced by the processes of cambering and valley bulging. It is emphasised that, at all stages in a clay's geological history, it is the bond strength between the soil particles, not the geological preconsolidation stress, that controls the mechanical behaviour of sedimentary clays. At all geological stages the bond strength contributes to sensitivity in terms of both stress state and strength. These sensitivities are measured against two intrinsic behaviour patterns, the intrinsic compression line and the intrinsic strength line, both of which are defined, and both of which have considerable value for the characterisation of clays. In particular, the relations between yield stress in oedometer compression and triaxial undrained strength enable the quality of laboratory test data to be assessed.
Engineering in stiff sedimentary clays
Authors: SIMPSON B.
Published: October 2010

The papers to the Symposium in Print are reviewed, looking in particular for insights and applications available to practising designers.† The papers display the complexity of the behaviour of stiff clays, and the very high level of expertise committed to researching it. The features of behaviour described, and to some extent quantified, are very important in understanding observed phenomena in conventional civil engineering situations. Studies of the stratigraphy of London Clay, as an example, show some helpful consistency across the deposit when results are plotted relative to its base, but also show that it is not a single, uniform material. Engineering at greater depth and with thermal effects, as required for nuclear repositories, provides some new challenges, involving both unfamiliar parameters and more familiar problems of characterising stiffness, strength and permeability, especially in bonded materials, set in a context of higher stresses. The combination of high-quality laboratory studies with field observations of full-scale behaviour remains essential to the development of geotechnical engineering, and both are well represented in the papers to the Symposium.
Analysis of the cone penetration test in layered clay
Authors: WALKER J. , YU H.-S.
Published: October 2010

This paper presents an analysis of the cone penetration test in multi-layered clays using the commercial finite-element code Abaqus/Explicit. The von Mises yield criterion and its associated flow rule are assumed to model the plastic behaviour of elastoplastic undrained clays. An arbitrary Lagrangian–Eulerian scheme and an enhanced hourglass algorithm are adopted to preserve the quality of mesh throughout the numerical simulation. Initially, the behaviour of the penetration resistance is examined in a soil with only two layers. The bottom layer is the weaker of the two and the behaviour of the penetration resistance when the cone approaches the lower layer is studied. The investigation is then extended to study the cone penetration test in a multi-layered clay by sandwiching a weaker clay layer between two stronger clay layers. The thickness of the weaker clay layer is varied and the behaviour of the penetration resistance is studied in relation to the thickness and relative strength of the soil layers. The results are discussed with respect to the soil mechanisms that are present when the cone moves past the relevant layer boundaries so that the position of these boundaries can be determined more accurately.
A microstructurally based effective stress for unsaturated soils
Authors: ALONSO E.E. , PEREIRA J.-M. , VAUNAT J. , OLIVELLA S.
Published: October 2010

Current alternative choices of stress state variables in unsaturated soils are described and compared, with a special focus on the use of an effective stress. Experimental data on stiffness and shear strength evolution with suction suggest that the proportion of suction contributing to the effective stress is often much smaller than predicted by the term ‘suction times degree of saturation' generally used in effective stress expressions of the Bishop type. It is suggested that effective stress in unsaturated soils should be related to soil microstructure. An effective degree of saturation is defined as describing the volume of water partially filling the soil macroporosity. This effective degree of saturation defines the proportion of the prevailing suction that actually contributes to the effective stress. Two alternative expressions (piecewise linear and non-linear) are proposed for the effective degree of saturation. They offer a similar performance. Available data on stiffness and shear strength variation with suction of a few different soils, ranging from a markedly granular material to high-plasticity clay, have been analysed. The analysis supports the proposed microstructural interpretation of the effective stress. Indeed, for granular soils the effective degree of saturation is almost equal to the total degree of saturation, and therefore the Bishop-type expression generally used as an effective stress is recovered. As the soil becomes more plastic, the proportion of free water reduces, and the contribution of suction to the effective stress reduces. At the limit, when the proportion of free water is negligible (this is the case of high-plasticity clays at high values of suction) the proposed effective stress reduces to the net stress (excess of total stress over the air pressure). The proposed effective stress equation may be identified if information on the amount of immobile water is available for a given soil. Water retention or porosimetry data provide this information. This has been shown by comparing the present proposal with independently obtained information about immobile water in high-plasticity clays.
Effectiveness of filters in reducing consolidation time in routine laboratory testing
Authors: SIVAKUMAR V. , MACKINNON P. , ZAINI J. , CAIRNS P.
Published: October 2010

The research reported here is based on the standard laboratory experiments routinely performed in order to measure various geotechnical parameters. These experiments require consolidation of fine-grained samples in triaxial or stress path apparatus. The time required for the consolidation is dependent on the permeability of the soil and the length of the drainage path. The consolidation time is often of the order of several weeks in large clay-dominated samples. Long testing periods can be problematic, as they can delay decisions on design and construction methods. Acceleration of the consolidation process would require a reduction in effective drainage length and this is usually achieved by placing filter drains around the sample. The purpose of the research reported in this paper is to assess if these filter drains work effectively and, if not, to determine what modifications to the filter drains are needed. The findings have shown that use of a double filter reduces the consolidation time several fold.
The use of particle size distribution by surface area method in predicting the saturated hydraulic conductivity of graded granular soils
Authors: TRANI L.D.O. , INDRARATNA B.
Published: October 2010

The hydraulic conductivity (k) of a fully saturated granular material can be predicted by the well-known Kozeny–Carman formula, and its slightly different variations, based on the porosity (n) and effective diameter (deff). Most variations of the Kozeny–Carman formula compute the parameter deff based on a given conventional particle size distribution by mass (PSDm), where the validation would normally be carried out by comparing against laboratory permeability tests conducted on soils having an average coefficient of uniformity (Cu) of about 3. Knowing that the Kozeny–Carman formula was originally developed for uniformly graded materials, inevitable limitations are inherited when it is applied to increasingly graded soils. This study proposes to convert the PSDm into its equivalence in surface area (PSDsa) conforming to the fundamental geometric assumption by which the Kozeny–Carman equation was originally formulated. The estimated deff based on this proposed PSDsa method appears implicitly to incorporate the size, shape and angularity of the natural grains which were traditionally represented by the shape coefficient (α). The results presented in this paper show that the suggested method is capable of predicting k for fully saturated granular soils with Cu of up 20.
Simulation of the Transport Phenomena during Food Drying with Ohmic Heating in a Static System
Authors: Keshavarz Moraveji Mostafa , Ghaderi Emad , Davarnejad Reza
Published: October 2010

In this article, the computational fluid dynamics (CFD) technique was used to simulate mass and heat transfer during the food drying via ohmic heating process. The effects of electrical field intensity, electrical conductivity, solid heating, liquid-solid conductivity and some parameters such as drying rate, moisture content and temperature changes on drying process of potato were investigated. The partial differential equations for the unsteady-state system were solved by the finite element method. In this modeling, simultaneous solution of the equations of heat transfer, moisture and electrical field was achieved. The results showed that ohmic heating process reduced drying time and accelerate the diffusion in the entire product in comparison with the other conventional methods. Therefore, heat and mass transfer were simultaneously and approximately conducted with the same rate in both phases of solid and liquid.
Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana)
Authors: J. Divers Stephen , Papich Mark , McBride Michael , L. Stedman Nancy , Perpinan David , F. Koch Thomas , M. Hernandez Sonia , Heather Barron G. , Pethel Melinda , C. Budsberg Steven
Published: November 2010

Objective—To determine pharmacokinetics of meloxicam in healthy green iguanas following PO and IV administration and assess potential toxicity.

Animals—21 healthy green iguanas (Iguana iguana).

Procedures—To assess pharmacokinetics, 13 iguanas were administered a single dose (0.2 mg/kg) of meloxicam PO and, 14 days later, the same dose IV. To assess potential toxicity, 4 iguanas were given meloxicam at a dosage of 1 or 5 mg/kg, PO, every 24 hours for 12 days, and results of histologic examination were compared with results for another 4 iguanas given a single dose of meloxicam (0.2 mg/kg).

Results—There were no significant differences between PO and IV administration with regard to terminal half-life (mean ± SD, 12.96 ± 8.05 hours and 9.93 ± 4.92 hours, respectively), mean area under the curve to the last measured concentration (5.08 ± 1.62 μg•h/mL and 5.83 ± 2.49 μg•h/mL), volume of distribution (745 ± 475 mL/kg and 487 ± 266 mL/kg), or clearance (40.17 ± 10.35 mL/kg/h and 37.17 ± 16.08 mL/kg/h). Maximum plasma concentration was significantly greater following IV (0.63 ± 0.17 μg/mL) versus PO (0.19 ± 0.07 μg/mL) administration. Time from administration to maximum plasma concentration and mean residence time were significantly longer following PO versus IV administration. Daily administration of high doses (1 or 5 mg/kg) for 12 days did not induce any histologic changes in gastric, hepatic, or renal tissues.

Conclusions and Clinical Relevance—Results suggested that administration of meloxicam at a dose of 0.2 mg/kg IV or PO in green iguanas would result in plasma concentrations > 0.1 μg/mL for approximately 24 hours. (Am J Vet Res 2010;71:1277–1283)
Personality, Acculturation, and Psychosocial Adjustment of Chinese International Students in Germany
Authors: Zhang Jingyu , Mandl Heinz , Wang Erping
Published: November 2010

The effect of personality traits and acculturation variables on cross-cultural adjustment were investigated in 139 Chinese students in Germany (52% girls; M age = 25.3 yr., SD = 2.9). Participants were surveyed by house visits to their dormitories. Several scales were administered: (a) Big Five Inventory; (b) Vancouver Index of Acculturation; (c) sociocultural adjustment, general and academic; and (d) psychological adjustment, i.e., depression, self-esteem, and life satisfaction. Results showed that Neuroticism and Openness were two shared predictors of sociocultural adjustment. Agreeableness and mainstream acculturation were only related to general adjustment, while Conscientiousness was only related to academic adjustment. All facets of psychological adjustment were related to Neuroticism and Consciousness, while positive components (self-esteem and life satisfaction) were also related to Extraversion and Openness. No influence of heritage acculturation was found. The findings are discussed in light of measurement issues and the shared and unique individual predictors of the different facets of adjustment.
Red Flags: To Screen or Not to Screen?
Authors: Ross Michael D. , Boissonnault William G.
Published: October 2010

The physical therapy profession has long recognized the importance of physical therapists determining whether a need for a patient referral to another healthcare practitioner exists. This clinical decision is based on physical therapists recognizing patient history and physical examination red flag findings consistent with pathology that requires physician consultation and examination. The challenge to physical therapists is the current lack of evidence describing what red flag findings are representative of specific pathological conditions. J Orthop Sports Phys Ther 2010;40(11):682–684. doi:10.2519/jospt.2010.0109
Stimulus-evoked electromyography testing of percutaneous pedicle screws for the detection of pedicle breaches: a clinical study of 409 screws in 93 patients
Authors: Wang Michael Y. , Pineiro Guillermo , Mummaneni Praveen V.
Published: November 2010

Object

Percutaneous pedicle screws have recently become popularized for lumbar spinal fixation. However, successful anatomical hardware placement is highly dependent on intraoperative imaging. In traditional open surgery, stimulus-evoked electromyography (EMG) responses can be useful for detecting pedicle screw breaches. The use of insulated sleeves for percutaneous screws has allowed for EMG testing in minimally invasive surgery; however, no reports on the reliability of this testing modality have been published.

Methods

A total of 409 lumbar percutaneous pedicle screws were placed in 93 patients. Levels of instrumentation included L-1 (in 12 patients), L-2 (in 34), L-3 (in 44), L-4 (in 120), L-5 (in 142), and S-1 (in 57 patients). Intraoperative EMG stimulation thresholds were obtained using insulating sleeves over a metallic tap prior to final screw placement. Data were compared with postoperative fine-cut CT scans to assess pedicle screw placement. Data were collected prospectively and analyzed retrospectively.

Results

There were 5 pedicle breaches (3 medial and 2 lateral; 3 Grade 1 and 2 Grade 2 breaches) visualized on postoperative CT scans (1.2%). Two of these breaches were symptomatic. In 2 instances, intraoperative thresholds were the sole basis for screw trajectory readjustment, which resulted in proper placement on postoperative imaging. Thirty-five screw trajectories were associated with a threshold of less than 12 mA. However, all breaches were associated with thresholds of greater than 12 mA. Using thresholds below 12 mA as the indicator of a screw breach, this resulted in a sensitivity of 0.0, specificity of 90.3, positive predictive value of 0.0, and negative predictive value of 0.98. Utilizing a threshold of any decreased stimulus (< 20 mA) would have detected 60% of breaches, with a mean threshold of 16.25 mA.

Conclusions

While these data are limited by the low number of radiographic breaches, it appears that tap stimulation with an insulating sleeve may not be reliable for detecting low-grade radiographically breached pedicles using typical stimulation thresholds (< 12 mA). Imaging-based modalities remain more reliable for assessing percutaneous pedicle screw trajectories until more robust and sensitive electrophysiological testing methods can be devised.
Neuroendoscopic treatment of arachnoid cysts of the quadrigeminal cistern: a series of 14 cases
Authors: Cinalli Giuseppe , Spennato Pietro , Columbano Laura , Ruggiero Claudio , Aliberti Ferdinando , Trischitta Vincenzo , Buonocore Maria Consiglio , Cianciulli Emilio
Published: November 2010

Object

In this paper, the authors' goal was to evaluate the role of neuroendoscopy in the treatment of arachnoid cysts of the quadrigeminal cistern.

Methods

Between March 1995 and February 2008, 14 patients affected by arachnoid cysts of the quadrigeminal cistern were treated endoscopically. The cysts were classified according to their anatomical and radiological appearance. The most frequent form (Type I) extended infratentorially and supratentorially with a dumbbell shape. Type II cysts were confined to the infratentorial space and were associated with the most severe and acute form of hydrocephalus. Type III cysts presented a significant asymmetric expansion toward the temporal fossa. Ten patients underwent an endoscopic procedure as primary treatment and 4 as an alternative to shunt revision. In 6 cases, the first endoscopic procedure was ventriculocystostomy (VC) together with endoscopic third ventriculostomy (ETV). In the other 8 cases, the first endoscopic procedure was VC alone.

Results

In the 6 cases in which VC was performed with an ETV, the procedure was successful, and the patients did not require further surgery. Of the 8 cases in which the first endoscopic procedure performed was VC without ETV, 7 underwent reoperation. Four of these patients underwent endoscopic procedures (by reopening the obstructed VC and performing ETV or cystocisternostomy) 2, 4, 4, and 5 months later with final success in all cases. Three patients (all of whom were previously treated using ventriculo- or cystoperitoneal shunts) required shunt reimplantation (complete failure). Subdural collection developed in 1 case, which was managed by transient insertion of a subduroperitoneal shunt. Neurological and developmental outcomes were good except for 1 patient who did not show improvement in preoperative developmental delay. No transient or permanent morbidity or mortality was observed.

Conclusions

The analysis of this series suggests that arachnoid cysts of the quadrigeminal cistern and the associated hydrocephalus can be effectively treated by endoscopy; this approach allows the patient to be shunt independent in more than 78% of the cases. If endoscopy is used as first option, the success rate of endoscopic procedures observed in this series was 90%. Endoscopic third ventriculostomy should be associated with a VC to offer the highest success rate with a single procedure.
Surgical outcome for focal cortical dysplasia: an analysis of recent surgical series
Authors: Chern Joshua J. , Patel Akash J. , Jea Andrew , Curry Daniel J. , Comair Youssef G.
Published: November 2010

Object

Focal cortical dysplasia (FCD) is an important cause of intractable epilepsy and is at times treatable by resection. The now widespread use of MR imaging and recent advancement of functional imaging have increased the number of patients undergoing surgical treatment for FCD. The objective of this review is to critically examine and to provide a summary of surgical series on FCD published since 2000.

Methods

Studies concerning surgery for FCD were identified from MEDLINE and references of selected articles and book chapters. Data from these included studies were summarized and analyzed to identify factors correlated with seizure outcome.

Results

Sixteen studies were identified, and 469 patients met our selection criteria. Seizure-free outcome at 1-year postoperatively was achieved in 59.7% of the patients. Children and adults were equally likely to benefit from the surgery. Complete resection (OR 13.7, 95% CI 6.68–28.1; p < 0.0001) and temporal location (OR 2.15, 95% CI 1.26–3.69; p = 0.0073) were two positive prognostic indicators of seizure-free outcome. Utilization of invasive monitoring did not affect the chance of seizure remission, but firm conclusions could not be drawn because patients were not randomized.

Conclusions

The advancement of modern imaging has transformed the process of surgical candidate selection for partial epilepsy due to FCD. Patients from recent surgical series were more homogeneous in their clinical presentations and might represent FCD as an independent pathological entity. This likely explained the improved surgical outcome for this group of patients. These reports also documented the increased utilization of functional imaging, but their efficacy needs to be verified with further studies.
Suprasellar arachnoid cyst resulting in the syndrome of inappropriate antidiuretic hormone secretion
Authors: Beier Alexandra D. , Cheshier Samuel H. , Chakraborty Aabir , Dirks Peter
Published: November 2010

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is occasionally seen after hypothalamic injury or dysfunction, although it typically occurs in association with other endocrine disturbances. It is has never been described as a presenting feature of a suprasellar arachnoid cyst (SAC) in the pediatric population. The authors describe the case of an enlarging SAC resulting in SIADH as the only presenting feature, with an otherwise normal hypothalamic-pituitary axis.

An SAC was diagnosed in utero in this 5-month-old girl who had a normal functioning hypothalamic-pituitary axis on presentation. Because of cyst enlargement and hydrocephalus, the patient was scheduled for surgery; however, preoperative labs revealed SIADH. After stabilizing the serum sodium concentration with fluid restriction and the administration of 3% sodium chloride, the patient underwent endoscopic cyst fenestration. Postoperatively, she had complete resolution of the SIADH.

Syndrome of inappropriate antidiuretic hormone secretion as the presenting symptom of an SAC has not been previously described. In the aforementioned patient, the proposed mechanism for SIADH was enlargement of the suprasellar arachnoid cyst causing compression of the supraoptic and paraventricular nuclei and thus overstimulating the secretion of arginine vasopressin, which resulted in SIADH.

The association of SIADH with an SAC is reportable, as is the resolution of the SIADH via cyst fenestration. The authors suggest that SIADH is an uncommon presenting feature of SACs and that syndrome resolution is possible with cyst decompression.
Perineurioma of the sciatic nerve: a possible cause of idiopathic foot drop in children
Authors: Ferraresi Stefano , Garozzo Debora , Bianchini Ezio , Gasparotti Roberto
Published: November 2010

The authors report on a loss of foot dorsiflexion in pediatric-age individuals and suggest that the possible cause could be a perineurioma of the sciatic nerve.

The authors describe 4 cases in which foot drop in the absence of sensory discomfort was the heralding sign of perineurioma of the sciatic nerve. Magnetic resonance imaging showed a focal enlargement of the sciatic nerve, but the tumor was confined only to its lateral compartment. Treatment in 2 cases involved excision of the affected segment and subsequent graft repair. The two other patients shared the same clinical, radiological, and surgical findings, but no nerve biopsy sample was obtained; the patients underwent only a tibialis posterior muscle transfer. Long-term recovery of nerve function never occurred.

Because tumor resection and nerve graft yield no functional results, a tendon transfer to restore walking may be the sole useful surgical procedure in these cases. Removal of the tumor may not be necessary because long-term follow-up confirms that perineuriomas are self-limiting and the final prognosis is favorable.
Screening of Bacterial Strains for Polygalacturonase Activity: Its Production byBacillus sphaericus(MTCC 7542)
Authors: Jayani Ranveer Singh , Shukla Surendra Kumar , Gupta Reena
Published: October 2010

At present almost all the pectinolytic enzymes used for industrial applications are produced by fungi. There are a few reports of pectinase production by bacterial strains. Therefore, in the present study, seventy-four bacterial strains, isolated from soil and rotten vegetable samples, were screened for polygalacturonase production. The strain PG-31, which gave maximum activity, was identified asBacillus sphaericus(MTCC 7542). Maximal quantities of polygalacturonase were produced when a 16-hours-old inoculum was used at 7.5% (v/v) in production medium and incubated in shaking conditions (160 rpm) for 72 hours. The optimal temperature and pH for bacterial growth and polygalacturonase production were found to be30∘Cand 6.8, respectively. Maximum enzyme production resulted when citrus pectin was used as the carbon source at a concentration of 1.25% (w/v), whereas other carbon sources led to a decrease (30%–70%) in enzyme production. Casein hydrolysate and yeast extract used together as organic nitrogen source gave best results, and ammonium chloride was found to be the most suitable inorganic nitrogen source. The supplementation of media with 0.9% (w/v) D-galacturonic acid led to a 23% increase in activity.Bacillus sphaericus, a bacterium isolated from soil, produced good amount of polygalacturonase activity at neutral pH; hence, it would be potentially useful to increase the yield of banana, grape, or apple juice.
The Role of Bacteria and Pattern Recognition Receptors in GvHD
Authors: Holler E. , Landfried K. , Meier J. , Hausmann M. , Rogler G.
Published: October 2010

Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. With the detailed description of pathogen-associated molecular patterns and pathogen recognition receptors single nucleotide polymorphisms of TLRs and especially NOD2 have been identified as potential risk factors of GvHD and transplant related complications thus further supporting the crucial role of innate immunity in SCT, related complications. Gastrointestinal decontamination and neutralization of endotoxin have been used to interfere with this early axis of activation with some success but more specific approaches of modulation of innate immunity are needed for further improvement of clinical outcome.
Progesterone and Bone: Actions Promoting Bone Health in Women
Authors: Seifert-Klauss Vanadin , Prior Jerilynn C.
Published: October 2010

Estradiol () and progesterone () collaborate within bone remodelling on resorption () and formation (). We integrate evidence that may prevent and, with antiresorptives, treat women's osteoporosis. stimulates osteoblast differentiationin vitro. Menarche () and onset of ovulation () both contribute to peak BMD. Meta-analysis of 5 studies confirms that regularly cycling premenopausal women lose bone mineral density (BMD) related to subclinical ovulatory disturbances (SODs). Cyclic progestin prevents bone loss in healthy premenopausal women with amenorrhea or SOD. BMD loss is more rapid in perimenopause than postmenopause—decreased bone formation due to deficiency contributes. In 4 placebo-controlled RCTs, BMD loss is not prevented by in postmenopausal women with increased bone turnover. However, 5 studies of -MPA co-therapy show greater BMD increases versus alone. fracture data are lacking. prevents bone loss in pre- and possibly perimenopausal women; progesterone co-therapy with antiresorptives may increase bone formation and BMD.
Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation
Authors: Urbanska Aleksandra Malgorzata , Paul Arghya , Bhahena Jasmine , Prakash Satya
Published: October 2010

The objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation. We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), prostaglandinE2  (PGE2), and thromboxane B2 in the digesta obtained from the duodenum, jejunum, proximal, and distal segments of the ileum of C57BL/6J-ApcMin/J mice. Formulation-receiving animals showed consistently lower proinflammatory cytokines' levels when compared to control group animals receiving empty alginate-poly-L-lysine-alginate (APA) microcapsules suspended in saline. The concentrations of IL-12 found in serum in control and treatment group animals were significant:46.58±16.96 pg/mL and158.58±28.56 pg/mL for control and treatment animals, respectively. We determined a significant change in plasma C-reactive protein:81.04±23.73 ng/mL in control group and64.21±16.64 ng/mL in treatment group. Western blots showed a 71% downregulation of cyclooxygenase-2 (COX-2) protein in treatment group animals compared to control. These results point to the possibility of using this yogurt formulation in anticancer therapies, in addition to chronic gut diseases such as Crohn's disease, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) thanks to its inflammation lowering properties.
Effectiveness of Ezetimibe in Reducing the Estimated Risk for Fatal Cardiovascular Events in Hypercholesterolaemic Patients with Inadequate Lipid Control While on Statin Monotherapy as Measured by the SCORE Model
Authors: Sampalis John S. , Bissonnette Stéphane , Boukas Stella
Published: October 2010

Objectives. The aim of this prospective cohort, multicentre study was to assess the effect of coadministrating ezetimibe 10 mg/day with an ongoing statin on the estimated risk for Cardiovascular (CVD) mortality in patients with persistently elevated LDL-C after statin monotherapy.Methods. The Systematic Coronary Risk Evaluation (SCORE) function was used to estimate the 10-year risk for cardiovascular mortality at baseline and 6 weeks. Primary outcome measures were absolute and percent changes in estimated Coronary Heart Disease (CHD) Mortality Risk, and general CVD Mortality Risk (Total CVD Mortality Risk).Results. 825 patients were included in the analysis. Mean (SD) age was 62 (10.5) years and 62.3% were males. The mean (SD) estimated Total CVD Mortality Risk decreased from 0.068 (0.059) at baseline to 0.053 (0.046) at 6 weeks (RR = 0.77; 95% CI:0.689–0.867), while the estimated CHD Mortality Risk decreased from 0.047 (0.040) at baseline to 0.034 (0.029) at 6 weeks (RR = 0.72; 95% CI:0.624–0.826).Conclusions. Co-administration of ezetimibe with a statin is effective in significantly reducing the estimated risk for cardiovascular mortality as measured by the SCORE model.
Study of Soybean Oil Hydrolysis Catalyzed by Thermomyces lanuginosus Lipase and Its Application to Biodiesel Production via Hydroesterification
Authors: Cavalcanti-Oliveira Elisa d'Avila , Silva Priscila Rufino da , Ramos Alessandra Peçanha , Aranda Donato Alexandre Gomes , Freire Denise Maria Guimarães
Published: October 2010

The process of biodiesel production by the hydroesterification route that is proposed here involves a first step consisting of triacylglyceride hydrolysis catalyzed by lipase from Thermomyces lanuginosus (TL 100L) to generate free fatty acids (FFAs). This step is followed by esterification of the FFAs with alcohol, catalyzed by niobic acid in pellets or without a catalyst. The best result for the enzyme-catalyzed hydrolysis was obtained under reaction conditions of 50% (v/v) soybean oil and 2.3% (v/v) lipase (25 U/mL of reaction medium) in distilled water and at 60∘C; an 89% conversion rate to FFAs was obtained after 48 hours of reaction. For the esterification reaction, the best result was with an FFA/methanol molar ratio of 1:3, niobic acid catalyst at a concentration of 20% (w/w FFA), and 200∘C, which yielded 92% conversion of FFAs to soy methyl esters after 1 hour of reaction. This study is exceptional because both the hydrolysis and the esterification use a simple reaction medium with high substrate concentrations.
Establishing Construct Validity of a Stages-of-Change Algorithm for Physical Activity
Authors: Kosma Maria , Ellis Rebecca
Published: November 2010

Purpose.

Examine the construct validity of a modified stages-of-change (SOC) scale among adults with physical disabilities by investigating the relations among the transtheoretical model (TTM) constructs, physical activity (PA), and SOC. Additionally, the SOC algorithm was compared with previously recommended SOC scales.

Design/Setting.

Cross-sectional online survey.

Subjects.

271 adults with physical disabilities ( x̄age = 49.25; 73.4% females).

Measures.

Standardized questionnaires for the TTM constructs and PA.

Analyses/Results.

Based on the multivariate analysis of variance, the hypothesized relations between the SOC and the TTM constructs were supported. According to the analysis of variance, PA levels increased almost linearly across the SOC. Precontemplators ( x̄ = 8.53 metabolic equivalent [MET]-h/d) had lower PA scores than contemplators ( x̄ = 14.27 MET-h/d) and preparators ( x̄ = 17.64 MET-h/d), who in turn had lower scores than those in action ( x̄ = 23.03 MET-h/d). Based on the direct discriminant function analysis, all TTM constructs were important predictors of the SOC (e.g., r = .85 for behavioral processes; r = .69 for self-efficacy; and r = .58 for cognitive processes). The most accurately predicted SOC were action (76.9%), precontemplation (70.6%), contemplation (44.6%), and preparation (14.9%), with an overall classification accuracy of 56.8%. The study participants were more evenly distributed across the SOC algorithm compared with previous studies.

Conclusion.

The construct validity of the SOC scale was supported. The scale differentiated almost linearly the levels of PA and most TTM constructs, and participants were well-represented across SOC. Health promoters should feel confident in using the proposed SOC scale and the TTM to implement stage-matched PA motivational programs.
The Impact of an Online Disease Management Program on Medical Costs among Health Plan Members
Authors: Schwartz Steven M. , Day Brian , Wildenhaus Kevin , Silberman Anna , Wang Chun , Silberman Jordan
Published: November 2010

Purpose.

This study evaluated the economic impact of an online disease management program within a broader population health management strategy.

Design.

A retrospective, quasi-experimental, cohort design evaluated program participants and a matched cohort of nonparticipants on 2003–2007 claims data in a mixed model.

Sample.

The study was conducted through Highmark Inc, Blue Cross Blue Shield, covering 4.8 million members in five regions of Pennsylvania. Overall, 413 online self-management program participants were compared with a matched cohort of 360 nonparticipants.

Measures.

The costs and claims data were measured per person per calendar year. Total payments were aggregated from inpatient, outpatient, professional services, and pharmacy payments. The costs of the online program were estimated on a per-participant basis. All dollars were adjusted to 2008 values.

Intervention.

The online intervention, implemented in 2006, was a commercially available, tailored program for chronic condition self management, nested within the Blues on CallSM condition management strategy.

Analysis.

General linear modeling (with covariate adjustment) was used. Data trends were also explored using second-order polynomial regressions.

Results.

Health care costs per person per year were $757 less than predicted for participants relative to matched nonparticipants, yielding a return on investment of $9.89 for every dollar spent on the program.

Conclusions.

This online intervention showed a favorable and cost-effective impact on health care cost.
Metacognitive Theory and Therapy for Worry and Generalized Anxiety Disorder: Review and Status
Authors: Wells Adrian
Published: October 2010

The metacognitive model of pathological worry and Generalized Anxiety Disorder (GAD) makes a crucial distinction between two types of worry and explains the persistence and uncontrollability of negative thinking as an effect of specific metacognitions. The negative appraisal of worry (meta-worry) and negative beliefs about worry are central to the development of GAD. Furthermore, GAD is associated with paradoxes in mental control such as the use of extended thinking to reduce thinking. Evidence is reviewed that supports major tenets of the model. A specific treatment, metacognitive therapy is described that focuses on modifying metacognitive beliefs and reducing the use of worry to cope with thoughts. The empirical status of the model is reviewed and evidence from recent trials of this treatment is summarized. The treatment appears to be effective and initial trials suggest it is associated with greater levels of recovery than approaches comprised of applied relaxation or cognitive-behavioural treatment focused on intolerance of uncertainty.
Can The Future-Oriented Nature of Worry be Experimentally Manipulated? The Effects of Personally Relevant Worry and Video-Related Imagery following Exposure to a Distressing Video
Authors: Pruitt Larry D. , Hazlett-Stevens Holly
Published: October 2010

In an attempted experimental manipulation of the future-oriented property of worry, a total of 174 college students were randomly assigned to one of five experimental conditions. After all participants viewed a distressing video, they were instructed to worry about a personally relevant topic while constraining their worry to outcomes that could occur within the next 15 minutes, within the next week, or within the next year, or they worried about a personally relevant topic without such a time constraint or engaged in imagery of the video. Predicted group differences in state anxiety reduction were not found, although this effect approached statistical significance (p = .07). Contrary to our prediction, the imagery group reported more subsequent video-related cognitive intrusions than the worry groups and no differences between the worry groups were found. Results suggest that worry about everyday concerns may effectively distract some individuals from previously experienced emotionally distressing material.
Elucidating the Relationship between Worry and Physical Health
Authors: Behar Evelyn , McHugh R. Kathryn , Otto Michael W.
Published: October 2010

Research indicates a relationship between trait worry and physical health, such that individuals with high levels of trait worry display physical health problems (e.g., upper respiratory infections, cardiological problems, immune system impairment). However, existing studies do not address whether three constructs that are theoretically and empirically related to worry – trait anxiety, anxiety sensitivity, and depression – might better account for the observed relationship between worry and physical health status. Participants completed measures of trait worry, trait anxiety, anxiety sensitivity, depression symptom severity, and health status. Results indicated that worry serves as a proxy risk factor for health status through the influence of trait anxiety and depressive symptoms, with both of these variables being related to mental health status, and only trait anxiety being related to physical health status. Anxiety sensitivity did not explain the relationship between trait worry and either type of health status. Theoretical and clinical implications are discussed.
Experimental Manipulation of Beliefs about Uncertainty: Effects on Interpretive Processing and Access to Threat Schemata
Authors: Deschenes Sonya S. , Dugas Michel J. , Radomsky Adam S. , Buhr Kristin
Published: October 2010

This study investigated the influence of beliefs about uncertainty on interpretive biases and access to threat schemata, with the use of an experimental manipulation. Individuals from the community and undergraduate students (N = 74) were randomly assigned to one of two experimental conditions: positive beliefs about uncertainty (n = 37) and negative beliefs about uncertainty (n = 37). To manipulate beliefs about uncertainty, participants watched a presentation on problem solving that either contained information about the positive or the negative effects of uncertainty on problem solving. To assess interpretive biases, participants completed a modified version of the Ambiguous/Unambiguous Situations Diary. Participants read potentially threatening passages and rated their level of worry. Passages were then disambiguated either positively or negatively and participants rated the likelihood and the value (goodness or badness) of these events. To assess access to threat schemata, the Catastrophizing Interview was administered. The Catastrophizing Interview is a structured worry task that assesses various aspects of the worry process, using the downward arrow technique. The results indicated that, although many of the expected group differences were not observed, participants in the negative beliefs about uncertainty group did rate the positively disambiguated scenarios as less positive and the average likelihood of feared consequences to personal worries as more probable. This study provides partial support for the notion that beliefs about uncertainty may have a causal effect on interpretations of ambiguous situations as well as on ease of access to threat schemata.
When Worries Make you Sick: A Review of Perseverative Cognition, the Default Stress Response and Somatic Health
Authors: Verkuil Bart , Brosschot Jos F. , Gebhardt Winifred A. , Thayer Julian F.
Published: October 2010

Perseverative cognition, such as worry and rumination, is a common reaction to stressful events. In this review, we present a self-regulation perspective on perseverative cognition and propose that it forms part of the default response to threat, novelty and ambiguity. This default response is enhanced in chronic worriers who show difficulties in recognizing signals of safety, due to excessive goal commitment and the use of perseverative cognition as a strategy to cope with perceived threats to goal attainment. It is proposed that worrying about stressful events increases the total amount of time that stress has a ‘wear and tear’ effect on the human body. Studies supporting this perseverative cognition hypothesis are reviewed. Moreover, we provide preliminary evidence that unconscious forms of perseverative cognition have substantial somatic health effects as well. In conclusion, a focus on perseverative cognition is warranted when investigating links between stressful events and somatic health.
Saharan dust and ice nuclei over Central Europe
Authors: Klein H. , Nickovic S. , Haunold W. , Bundke U. , Nillius B. , Ebert M. , Weinbruch S. , Schuetz L. , Levin Z. , Barrie L. A. , Bingemer H.
Published: November 2010

Abstract. Surface measurements of aerosol and ice nuclei (IN) at a Central European mountain site during an episode of dust transport from the Sahara are presented. Ice nuclei were sampled by electrostatic precipitation on silicon wafers and were analyzed in an isothermal static vapor diffusion chamber. The transport of mineral dust is simulated by the Eulerian regional dust model DREAM. Ice nuclei and mineral dust are significantly correlated, in particular IN number concentration and aerosol surface area. The ice nucleating characteristics of the aerosol as analyzed with respect to temperature and supersaturation are similar during the dust episode than during the course of the year. This suggests that dust may be a main constituent of ice nucleating aerosols in Central Europe.