bluuebunny/crossref_metadata_2025 huggingface dataset:
Applying the Delphi method with early-career researchers to explore a gender-issues agenda in STEM education
Authors: Hernandez-Martinez Paul , Dominguez Angeles , Zavala Genaro , Kambouri Maria , Zubieta Judith , Clark Robin
Published: October 2022

The Delphi method (DM) was initially conceived as a forecasting technique whose results are based on the consensus of a panel of experts. It has been used in many fields, assisting researchers, policymakers, and others in setting directions and future agendas. This study presents an application of the DM, with a broader interpretation of the notion of “expert” as a qualitative tool to explore gender issues in science, technology, engineering, and mathematics (STEM) education. Its aim is to analyze the use of the DM as a technique to achieve agreement among a group of early-career researchers from the UK and Mexico, who are not considered “experts” in the traditional sense. The other aim was to explore the advantages and disadvantages of using the DM in this context. We used three stages to collect information and reach a consensus. The first two were online activities, and the last consisted of a five-day face-to-face workshop. In the first stage, participants sent research questions, and organizers categorized them into themes. Participants responded to a survey ranking all research questions in the second stage. In the last, organizers analyzed the highest scored questions and arranged them into research topics in which participants worked on research proposals. The DM worked successfully with this group of participants by combining their interest in the field and engagement with the activities. The research strands and proposals of using this method are usable. The method used in this paper can serve as a model to develop research graduate courses to develop students’ skills.
Identification of deactivation procedure for Trilaciclib
Authors: Raghuveera Hathibelagal Goruva  , Anjaneyulu Vinukonda  , Neelesh Chaubey  , Harish Pandey
Published: October 2022

The Indian health-care facilities (HCFs) made some guidelines related to cytotoxic drugs so called cytotoxic policy for patient safety and health-care worker safety, and environmental monitoring program as per the available international guidelines. Trilaciclib is indicated for the treatment of patients with multiple myeloma and chemically it is a tetra peptide epoxy ketone and an analog of epoxomicin. Analytical method for the detection of Deactivating agent and concentration play an impartment role in the pharmaceuticals especially with cytotoxic molecules after completion of manufacturing and testing is mandatory to follow the safety protocol to dispose those materials. The present invention provides to identify the suitable deactivating agent for the neutralization of Trilaciclib injection 10 mg/mL and Trilaciclib API with respect to concentration and time. This method developed based by RP-HPLC.
Biostimulant derived from the fermentation of Inulav viscosa (Inort) in the germination and growth of Amaranthus hypochondriacus
Authors: Domenico Prisa  , Francesco Attanasio
Published: October 2022

Research objective: This research aims to evaluate Inula's bio-stimulating potential in the form of macerate in water in the cultivation of Amaranthus hypochondriacus. This is to increase knowledge of this plant that commonly exhibits inhibitory characteristics towards the germination of various plants. Materials and Methods: The experiments started in May 2022 and were conducted in the greenhouses of CREA-OF in Pescia on Amaranthus hypochondriacus plants. On September 24, 2022, plant height, leaves number, leaves the surface area, vegetative weight, roots volume and length, the number of germinated seeds, average germination time, the number of microorganisms in the substrate, plant dead number and pH were determined. In addition, the SPAD index was measured on three leaves pinched from the bottom to the apex of the canopy of each plant (for a total of 90 measurements per treatment) and tissue mineral content was evaluated on collected dry matter (N, P, K, Ca, Mg, Fe and Na, Cl). Results and Discussion: The experiment showed that using Inula as a bio stimulant can significantly improve germination and growth and reduce mortality in Amaranthus hypochondriacus plants. In general, a significant increase in plant height and number of leaves, vegetative and root biomass was observed in plants treated with INORT, with differences depending on the percentage of product supplied to the plants. There was also a significant reduction in the mortality of plants treated with the biofertilizer product and increased microbial biomass. The trial also showed that the Inula biofertilizer could improve the chlorophyll content of the plant and increase the N, P, K, Ca, Fe, and Na content, while no differences were found for the parameters Mg and Cl. This test also shows biostimulant effects regarding seed germination and the average germination time reduction. This is interesting because Inula is usually mentioned for its inhibiting activity in seed germination, which probably depends on the transformation process. However, when macerated with microbial products, the inhibiting activity is nullified, and the fast-growing microorganisms utilize the organic products provided by this plant. Conclusions: In this experiment, further exciting and innovative aspects were highlighted in the use of this plant, given its already recognized importance from a medicinal, melliferous and biodiversity point of view. More experiments are underway to improve the protocol for using a biofertilizer based on Inula and microorganisms for horticulture for plant stimulation and defence.
The Relevance of the Principles of Psychological Education and the Goals of Islamic Education Based on the Qur'an and Hadith
Authors: Matara Kusmawaty
Published: October 2022

This study aims to find the relevance between the principles of psychological education and the goals of Islamic education based on the Qur'an and hadith. For this reason, the data we get is sourced from scientific findings from psychology and Islamic education experts from various sources, books, and scientific articles. We have studied all of that carefully under a phenomenological approach, an approach to collecting as much data as possible to find something phenomenal in this case that can answer the problems and hypotheses of this study. Therefore, based on this study and the discussion of these two variables, we find that there is very little significant relevance between the principles of psychological education and the goals of Islamic education based on the Qur'an and other sources that are believed to have relevance to the two variables above. It is hoped that these findings will become necessary inputs in supporting similar studies in the future, and this study will become input for the implementation of improving education, psychology, and Islamic religious studies.
Dimensions of Divine Philosophy Education
Authors: M Dawud Faza Abrar , Nasution Ismail Fahmi Arrauf , Ibrahim
Published: October 2022

This research is about the rationality of the "number" of tawhid in Islamic studies; This study has developed in the Eastern and Western Islamic worlds carried out by Muslim scholars. The discussion “number” of tawhid is widely found in classical Islamic literature, such as in the science of kalam, Islamic philosophy and tasawwuf; this indicates that the number of tawhid is significant. This study aims to answer how the numbers in the tradition of Islamic studies; The methodology used is a qualitative method with the type of library research because the data obtained are in the form of documents sourced from a book. The findings of this study indicate that the number one in tawhid implies perfection, so the science of tawhid discusses the model of the Perfect God; the number of tawhid includes its discussion in the three fields of Islamic scholarship fiqh, tawhid and tasawwuf. Issues regarding the tawhid argument understand the “number” of tawhid, which is a relative human construction. In Islam, numerology is not only discussed in philosophical themes, especially in the science of ushuluddin (Islamic theology) and Sufism (Islamic mysticism) as the central theme. The use of number symbolism in the three fields of Islamic scholarship is used as the basis for strengthening Imad ad-din (the pillar of religion), namely the number One (Wahid) as the "number of tawhid".
Juridical Overview of the Use of Smart Contracts in Indonesia as a Form of Artificial Intelligence Development
Authors: Baihaiqi Muhammad Rizqon , Adillah Siti Ummu , Hasana Dahniarti
Published: October 2022

Apart from the problems in terms of data security in the midst of blockchain-based business development in Indonesia, it turns out that another problem in smart contracts is that the use of Smart Contracts in Indonesia is actually still a discourse among legal experts regarding the validity of smart contracts. The aims of this research are: a) To find out and analyzeimplementation of the use of smart contracts in Indonesia; b) To know and analyzeobstacles in implementing smart contracts in Indonesia and their solutions; c) To know and analyzelegal remedies that can be taken in the event of a dispute between the parties in the smart contract; d) To find out examples of deeds inthe use of smart contracts in Indonesia as a form of artificial intelligence development." Researchers used normative research specifications with secondary data sources. Stages to find the target, then used the approach through legislation (statute approach). The results were juridical review of the use of smart contracts in Indonesia based on Article 1320 of the Civil Code.Article 1338 of the Civil Code explains that “all agreements made legally valid as law for those who make them”. One of the uses of smart contracts on Ethereum. Thereuem's smart contract has the name ERC20.Article 3 Regulation of the Commodity Futures Trading Supervisory Agency Number 5 of 2019 concerning Technical Provisions for the Implementation of the Physical Market of Crypto Assets on the Futures Exchange, Bitcoin which can be traded on the Futures Exchange.Barriers to implementing Smart Contracts in Indonesia and their solutionsimplementing ISO-based Information Security Management or the simplest following the National Institute of Standards and Technology (NIST) framework. ISO 27001:2013 is the latest ISO 27000 series released in 2013. ISO 27001:2013.Article 30 Paragraph (3) in conjunction with Article 40 Paragraph (3) of Act No. 1 of 2008 concerning Information and Electronic Transactions.
Validity of Addendums which Made Under Hands Due to a Default on Cooperation Agreement Deed
Authors: Yuliana Lely , Hafidz Jawade , Maerani Ira Alia
Published: October 2022

This writing aims to find out and analyze the validity of the addendum made by the parties under the hand due to the occurrence of default of the cooperation agreement deed made before a Notary and to know and analyze the legal considerations by the judge in deciding the case number 15/Pdt.G/2016/PN.Kds. This research method uses a normative juridical approach, which is an approach using secondary data as the main data. Secondary data is data obtained by conducting library research. The results of this study indicate that basically in an agreement it is allowed to add an addendum on the condition that the parties agree, this is because in the addition of an addendum to add, changing or eliminating something in the agreement is always related to the main agreement, as stipulated in Article 1320 of the Civil Code regarding the conditions for the validity of the agreement. The main key to an addendum is the agreement of the parties in accordance with Article 1320 of the Civil Code.
The Role of Notary in Making the Deed on Inheritance of Land Rights
Authors: Kanna Muhammad Rofik , Sulchan Achmad , Riyanto Taufan Fajar
Published: October 2022

This writing aims to determine the process of dividing the inheritance of land rights by a notary and theoretical analysis of the role of a notary in making a deed of inheritance of land rights. The role of a Notary in the transfer of land rights based on inheritance is very large, where every transfer of land rights must be proven by a deed made by and before a Notary so that the deed he makes has binding legal force. The researcher used a legal research method with a normative juridical approach, the research specifications used were descriptive analysis, the data source came from secondary data. Methods of data collection were conducted through interviews, library research, and document studies. This writing was analyzed qualitatively by using the analytical knife of legal certainty theory and Islamic justice theory. The results showed that the process of distributing inheritance rights to land carried out by a Notary, namely the parties (heirs) together faced the Notary in the presence of 2 (two) witnesses. Both parties bring the files that are the formal requirements and the material requirements that have been determined. Theoretical analysis of the role of the notary in making the deed of distribution of inheritance rights to land is carried out with justice, so it is fair not justice. This is similar to Islamic justice theory. Basically the concept of justice in Islam is not "equality" but "comparability".
Legal Consequences of the Merger of Companies on the Implementation of Guarantee Function of Mortgage
Authors: Kurniawan Halim Ady , Handoko Widhi , Hafidz Jawade , Hanim Lathifah
Published: October 2022

This study aims to: 1) Knowing and analyzing the execution of mortgage guarantees due to the company merger, 2) Knowing and analyzing the legal consequences of the merger on mortgage holders to be executed, 3) Knowing the deed of settlement resulting from the company merger on the implementation of the mortgage guarantee function. The research method used empirical juridical, namely by collecting data or statutory regulations, as well as conducting interviews with related respondents. The specifications used in this study were descriptive analysis. Researchers used empirical specifications with primary and secondary data. The primary data used were obtained directly through the opinions and statements of the respondents through interviews and the reality in the field through observation. The secondary data used by the researcher is carried out by conducting a literature study by reviewing, analyzing and then processing it into a descriptive narrative so that it is easy to understand when read. The data analysis method used by researchers from the stages of primary and secondary data obtained would be descriptive-qualitative analysis. Based on the research, it can be concluded that the legal consequences of the company merger on the implementation of the mortgage guarantee function of the old company that had merged did not renew the credit agreement and mortgage certificate after the merger, so that the new company could not carry out the execution due to the negligence of the old company. Even though the guarantee is in the old company's control, the bank is only the seller of the goods, it remains the property of the debtor so that it is against propriety and violates the rights of the owner of the goods if the bank violates it by selling cheap prices. In accordance with developments in Indonesia after the birth of the Mortgage Law, the grosse deed is still maintained by introducing the mortgage certificate which also uses irah-irah so that it has executive power.
Latines en La Araucana (o cómo leyó Ercilla La Eneida y La Farsalia)
Authors: Gómez Canseco Luis
Published: October 2022

There is no doubt that The Aeneid and The Pharsalia were very important sources in the composition of La Araucana. However, we do not know for sure whether Ercilla read Virgil and Lucan in their original version or in translation. This work attempts to resolve this question. In order to do so, the passages of La Araucana are compared with the Latin versions of the works of both poets, as well as with their Spanish translations. The work concludes that Ercilla used the Castilian texts, although in some cases he may have referred to the Latin text of The Aeneid.
Gérard de Nerval’s Mysticism: A Mystico-Symbolic Analysis
Authors: Raimondo Riccardo
Published: October 2022

In the seven sonnets that form the section Mysticisme included in the volume Petits Châteaux de Bohême (1852), Gérard de Nerval possibly deals for the first time with a spiritual theme in an organic and structured way. It is a poetic project that anticipates the depth of the Chimères, as well as the fascination of the Filles du feu and Aurélia. The analysis of this sonnet sequence allows us to address the foundational themes and spiritual inspirations informing Nerval’s subsequent works. Through a ‘geometric conjecture’ based on three symbols – the cross, the circle, and the triangle – this article aims at providing a personal interpretation of Mysticisme.
ὤτοις (Phryn. Ecl. 182)
Authors: Favi Federico
Published: October 2022

This article deals with the analogical dative plural ὤτοις, discussed in the Atticist lexicon Phryn. Ecl. 182.
Da Parigi a Torino
Roberto d’Azeglio, la destinazione pubblica delle belle arti e la Reale Galleria
Authors: Failla Maria Beatrice
Published: October 2022

The aim of this paper is to investigate the events connected with the establishment of the Reale Galleria di Torino as a public museum in 1832 in relation to the training path of its first director, Roberto d'Azeglio, who was in voluntary exile in Paris, where he came into contact with artists from the entourage of David's pupils in the 1920s. The function of the museum for d'Azeglio is the same as that identified by Quatrémere de Quincy: an institution of high civic value strongly linked to the present. Contemporary art and ancient art can thus establish a close dialogue to consolidate the ethical and civic involvement of visitors.
The Effect of the Reader’s Theatre on Reading Fluency and Reading Comprehension Skills of 4th Grade Primary School Students
Authors: BABACAN Kübra , YILDIZ Mustafa
Published: October 2022

In this study, reader’s theater’s effect on reading comprehension and fluency skills was examined. In research, quasi-experimental design was used. The research was applied in a public school in Mamak/Ankara for 14 weeks in the 2019-2020 Academic Year. 29 students took part in the research. In the experimental group reader’s theater activities were carried out by the researcher and no application was done with the control group. To find out the reading comprehension levels of the students, reading comprehension test was used. In addition, the word recognition percentage, reading speed and Reading Prosody Rubric was utilized to determine the participants’ reading fluency levels. As a result of the analysis, the reader’s theater method was efficient in the increase in reading prosody and reading fluency skills, and the decrease in the number of misspelled words. Although no significant effect of the reader’s theater method on the participants’ reading speed was observed, it was concluded that the reader’s theater method increased the participants’ reading comprehension skills.
Sociología de las fronteras sociolingüísticas en Argelia desde las actitudes hacia las lenguas
Authors: Hadibi Zahir , Berraghda Loucif Rabéa , Baaziz Saida
Published: October 2022

El objetivo del presente artículo consiste en presentar una visión sociolingüística de los idiomas presentes en Argelia y las políticas lingüísticas estatales hacia ellos. De igual modo, se esboza la pluralidad de las relaciones y actitudes de los usos sociolingüísticos diversos, partiendo del árabe clásico y dialectal, el francés y el tamazight (bereber). Por ello, se da una mirada retrospectiva sobre la historia de la configuración lingüística del país durante su historia contemporánea, ya que sería provechoso para comprender los asuntos políticos y sociales que caracterizan la cartografía lingüística actual, además se pone el foco en la definición del panorama lingüístico institucional de uso social y académico. Más bien, se valora la recomposición de la diversidad y su traducción empírica con sus complementariedades, dicotomías y oposiciones.
Die Potenziale von 5G für die Intralogistik der Zukunft
Authors:   Hochschule für Technik Stuttgart, Burghardt Julius , Höhn Lukas ,   Hochschule für Technik Stuttgart, Uckelmann Dieter ,   Hochschule für Technik Stuttgart
Published: October 2022

Der Einsatz der 5G-Technik bietet vielen Unternehmen enorme Chancen hinsichtlich ihrer Bemühungen, Prozesse zu optimieren. In der Logistik sind zahlreiche Anwendungsbereiche denkbar. Besonders die Intralogistik könnte aufgrund der besseren Ortungsgenauigkeit von 5G gegenüber 4G profitieren. In Betracht kommen Anwendungen wie die zielsichere Steuerung von Transportfahrzeugen oder die präzise Ortung von Material während des Produktionsprozesses. Gelingt es, das Ortungspotenzial der 5G-Technik vollends auszuschöpfen und in die Struktur der Intralogistik einzubinden, könnte dadurch der Produktionsablauf revolutioniert werden.
ASSESSMENT OF LAND RESOURCES OF THE ZHAMBYL REGION AS THE BASIS OF RECREATION DEVELOPMENT AND FOOD SECURITY OF THE REPUBLIC OF KAZAKHSTAN
Authors:   Abai Kazakh National Pedagogical University, Department of Geography, Ecology and Tourism, Almaty, Kazakhstan, ALDAZHANOVA Gulnar , BEISSENOVA Aliya ,   Abai Kazakh National Pedagogical University, Department of Geography, Ecology and Tourism, Almaty, Kazakhstan, SKORINTSEVA Irina ,   Institute of Geography and Water Security Science Committee, Almaty, Kazakhstan, MUSTAFAYEV Zhumakhan ,   Institute of Geography and Water Security Science Committee, Almaty, Kazakhstan, ALIASKAROV Duman ,   Abai Kazakh National Pedagogical University, Department of Geography, Almaty, Kazakhstan
Published: October 2022

The article presents the scientific results of a study for the assessment of agricultural land in Zhambyl region of the Republic of Kazakhstan based on field studies in 2020-2021 and modern GIS technologies. The purpose of the study of the article is a comprehensive assessment of land resources used for agricultural production in Zhambyl region, identifying the prevailing areas of agricultural land, irrigated and rainfed pastures by administrative districts of the region. In the course of the scientific study, proven Kazakhstani methods of assessing the state of agricultural land, successfully applied to the arid agricultural regions of Kazakhstan, as well as methods of geographical and agricultural sciences for land analysis and calculation according to the structure of use, were used. Based on the statistical data of the Committee of Land Resources and preliminary regional plans, a map of the land fund of the Zhambyl region by land categories was created. The results of the study allow business entities, especially farms, to organize the rational use of irrigated lands, including pastures and hayfields, including the sustainability and profitability of agricultural production, as well as successfully develop agro-landscape tourism.
Rational Organisation of Adverse Drug Reaction Monitoring
Authors: Shukil L. V. , Fominykh S. G. , Akhmedov V. A. , Perepichkina T. E.
Published: October 2022

The main pharmacoepidemiological method for assessing the efficacy and safety of ongoing pharmacotherapy involves the collection of spontaneous reports on adverse drug reactions (ADRs) associated with the use of medicines.The aim of the study was to analyse approaches to organising a system for collecting information on ADRs associated with the use of medicinal products, taking the Omsk region as a case study.Materials and methods: the authors analysed 200 ADR reporting forms received by the Regional Centre for the Study of Side Effects of Drugs (RCSSED) in 2019.Results: the analysis determined the ways of receiving the forms in the RCSSED. According to the analysis, the ADR reports were submitted by medical organisations in Omsk (86%) and the Omsk region (0.5%), as well as directly by patients (13.5%). The leading sources of reports were clinical pharmacologists (80% of the forms). Most of the reports were on ADRs associated with the use of psychotropic (41%) and antitumour (10%) medicinal products; it is explained by the proactive attitude and high commitment of medical personnel from the specialised clinics in Omsk towards their professional duties. Other important sources of reports in the Omsk region, which contributed to the number of spontaneous reports from patients, were the patient hotline and free consultation appointments with the clinical pharmacologist of the RCSSED on side effects of medicinal products. The article emphasises the leading role of the RCSSED clinical pharmacologist in educating medical personnel—in pharmacovigilance, collecting information about the development of ADRs, and the quality of reporting form filling—and coordinating the activities of the medical and pharmacy services, including the stages of laboratory assessment of medicinal product quality and pharmaceutical consultation of general public.Conclusions: using the example of the Omsk region, the authors demonstrated the structural organisation of the collection of information about adverse reactions associated with the use of medicinal products. An important direction for further improvement of the organisation of ADR monitoring is the interaction with employees of pharmacy organisations, including additional training events for them.
Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease
Authors: Velts N. Yu. , Zhuravleva E. O. , Kutekhova G. V. , Tereshkina N. V. , Lovkova A. O. , Gorelov K. V. , Polivanov V. A. , Gyulakhmedova S. M.
Published: October 2022

Adverse drug reactions (ADRs) are recorded throughout the lifecycle of a medicinal product. In the post-marketing period, new ADRs are primarily identified via drug safety signals. In order to assess a signal and establish causality between an adverse drug reaction and a suspected medicinal product, it is necessary to evaluate the signal strength and quality.The aim of the study was to analyse the information submitted to Russian regulatory authorities by a patient and check it for a potential causal association of acute tubulointerstitial nephritis (ATIN) with the use of ceftriaxone and with the patient’s principal diagnosis, Lyme disease.Materials and methods: the authors analysed the patient’s submission received by the Ministry of Health of the Russian Federation in 2022 with a complaint that the treatment of Lyme disease with ceftriaxone had caused ATIN. The probability of a causal relationship between the medicinal product and the ADR was evaluated using the Naranjo algorithm.Results: according to the review of literature and the spontaneous reports collected in Pharmacovigilance 2.0, the database in the Automated Information System of the Russian Federal Service for Surveillance in Healthcare, both ceftriaxone and the underlying condition (Lyme disease) may cause renal abnormalities. Ceftriaxone is potentially nephrotoxic; it mainly affects the tubular system of the kidneys. Borreliosis may cause kidney damage as well; such damage manifests clinically as rapidly progressing and fatal damage to the glomeruli.Conclusions: the probability of a causal relationship between the development of ATIN in the complainant and the use of ceftriaxone was categorised as “possible”. However, the information available did not allow for establishing a definite relationship between kidney damage and the use of the medicinal product. Further monitoring of similar cases is necessary to minimise the risks of developing this pathology during treatment with ceftriaxone.
Pharmacotherapy in a Multidisciplinary Paediatric Hospital: Polypharmacy and Drug–Drug Interaction Risk Illustrated with a Clinical Case
Authors: Kostyleva M. N. , Strok A. B. , Postnikov S. S. , Gratsianskaya A. N. , Ermilin A. E.
Published: October 2022

Nowadays, the problems caused by polypharmacy are recognised and widely discussed in the medical community. Multimorbidity, which is not uncommon in paediatric practice, comes with an increase in the number of prescriptions and necessitates an active search for tools to reduce the potential risk and frequency of adverse drug–drug interactions in paediatric patients.The aim of the study was to use a clinical case to illustrate the need for monitoring, including laboratory monitoring of pharmacokinetic parameters, during concomitant therapy in paediatric practice.Materials and methods: the study consisted in a retrospective analysis of the archived medical records of an 11-year-old child with nephrotic syndrome associated with a concomitant tuberculous process who had been receiving inpatient treatment with immunosuppressants at the Russian Children’s Clinical Hospital from May to July 2018.Results: the prescription of cyclosporine for nephrotic syndrome entailed monitoring of plasma drug levels for potential pharmacokinetic interactions with the medicinal products used to treat the concomitant disease. The monitoring revealed an interaction between cyclosporine and rifampicin at the level of biotransformation. An adjustment of the concomitant therapy (discontinuation of rifampicin) allowed for achieving the target blood cyclosporine concentration, decreasing proteinuria and hypercholesterolemia, and increasing the blood total protein level in the child, which indicated the effectiveness of the ongoing treatment for the chief complaint.Conclusions: the data obtained suggest that laboratory monitoring of pharmacokinetic parameters in paediatric polypharmacy can increase the effectiveness of therapy and prevent adverse reactions and irrational combination of medicinal products.
Дипептидные лиганды TSPO
Authors: Деева Ольга Алексеевна , Яркова Милада Альнордовна , Мокров Григорий Владимирович , Гудашева Татьяна Александровна , Середенин Сергей Борисович
Published: October 2022

Представлен обзор собственных работ по синтезу и изучению фармакологических свойств дипептидных лигандов транслокаторного белка TSPO. Соединения сконструированы на основе оригинальной химико-фармакологической стратегии дизайна коротких пептидных препаратов, подобных известным лекарственным средствам. Рассматривается два ряда дипептидных лигандов TSPO — замещенные триптофанил-изолейцины и замещенные триптофанил-лейцины. Приводятся данные об их анксиолитической активности и предполагаемых молекулярных механизмах действия соединений-лидеров, связь структуры и анксиолитической активности в ряду их аналогов. Описываются фармакофорные элементы, необходимые для проявления анксиолитического эффекта этих соединений. Формулируется гипотеза о структуре эндогенного лиганда TSPO.
Сравнительная активность хлонизола и темозоломида у мышей после интракраниальной трансплантации карциномы Эрлиха и HER2-положительного рака молочной железы
Authors: Александров Валерий Анатольевич , Стуков Александр Николаевич , Змитриченко Юлия Геннадьевна , Точильников Григорий Викторович
Published: October 2022

В продолжение доклинического изучения созданного нами нового алкилирующего противоопухолевого препарата — хлонизола (2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиола) дана оценка его активности при интракраниальной трансплантации мышам карциномы Эрлиха и HER2-позитивного рака молочной железы. Темозоломид, используемый при лечении злокачественных глиом, выбран как референтный препарат с алкилирующим действием. На обеих моделях опухолей хлонизол достоверно увеличивал медиану продолжительности жизни животных-опухоленосителей, превосходя по активности темозоломид. При сравнении кривых выживаемости мышей с опухолевым трансплантатом HER2-положительного рака молочной железы в течение эксперимента выявлено отсутствие терапевтического эффекта у темозоломида, но очевидное увеличение выживаемости по срокам в группе с хлонизолом. Хлонизол может быть потенциальным цитостатиком в химиотерапии опухолевых поражений нервной системы, что особенно актуально для лечения HER2-позитивного рака молочной железы, который часто метастазирует в головной мозг.
Технологические подходы к микрокапсулированию жирных и эфирных масел при разработке лекарственных средств растительного происхождения
Authors: Семкина Ольга Александровна , Белошапкина Ольга Михайловна
Published: October 2022

В статье представлен материал, посвященный особенностям микрокапсулирования жирных и эфирных масел, предназначенных для разработки и получения лекарственных средств. Показаны преимущества микрокапсулирования жирных и эфирных масел. Описаны возможные методы получения микрокапсул растительных масел, охарактеризованы возможности и ограничения технологии микрокапсулирования масел растительного происхождения. Определены современные вспомогательные вещества, использующиеся в процессе инкапсулирования жирных и эфирных масел. Приведены примеры микрокапсулирования эфирных масел: мяты перечной (Mentha piperita L.), ромашки аптечной (Matricaria chamomilla L.), розмарина лекарственного (Rosmarinus officinalis L.) и т.д. Представлены примеры микрокапсулирования жирных масел: оливкового и миндального масел. Проанализированы отечественные и зарубежные источники литературы, размещенные в открытом доступе; использованы следующие электронные базы данных: PubMed, e-Library, Киберленинка и поисковая система Google-академия.
Определение физико-химических свойств помалидомида формы А
Authors: Даин Игорь Александрович , Золотов Сергей Анатольевич , Сазонов Георгий Константинович , Пономарев Евгений Сергеевич , Золотова Анна Сергеевна , Демина Наталья Борисовна
Published: October 2022

В работе приведены результаты установления структуры и полиморфной модификации фармацевтической субстанции (ФС) помалидомид производства ООО «АМЕДАРТ», РФ методами ЯМР-спектроскопии, дифференциальной сканирующей калориметрии (ДСК), рентгеновской порошковой дифрактометрии, которая соответствовала форме А. Впервые представлены микрофотографии, полученные методом сканирующей электронной микроскопии для ФС помалидомид, и охарактеризован ИК-спектр для полиморфной модификации А. Определена растворимость ФС в водных растворах солей, кислот и оснований с различным pH, а также в широком диапазоне органических растворителей с различной полярностью при разной температуре. На основании полученных данных о растворимости предложена оптимальная система очистки/перекристаллизации помалидомида из водного раствора ДМСО с pH от кислого до нейтрального, учитывающая свойства комбинации растворитель – антирастворитель для увеличения выхода продукта.
The Effect of Transformational Leadership on Employee Performance Through Organizational Citizenship Behavior in Industrial Revolution 4.0
Authors: Hidayat Samsul , Wirawan Ida Bagus , Adam Subagyo , Trisliatanto Dimas Agung , Abdullah Muhammad Ridhuan Tony Lim
Published: October 2022

The transformation of government organizations should be characterized by the development of visionary leadership transformation that was measured at various levels of leadership in government organizations, this was needed to ensure that every innovation developed could provide value-added service quality, harmonized the vision and internal environment which had balanced with the ability to respond to environmental changes external which moved quickly in this era of the Industrial Revolution 4.0. The purpose of this study was to analyze and examined the effect of transformational leadership on employee performance through organizational citizenship behavior in the Bulog of Indonesia for facing the industrial revolution era 4.0. The results of this study concluded that organizational citizenship behavior was an intervening variable in the effect of transformational leadership on employee performance in the Bulog of Indonesia facing the era of Industrial Revolution 4.0.
Review of the monograph Yu. L. Fedorchenko, N. V. Korneeva, A. N. Evseeva and M. V. Martynyuk “Diseases of the upper gastrointestinal tract in diabetic patients”
Authors: Lazebnik L. B.
Published: October 2022

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Quality of College Virtual Teaching and Learning during Covid-19 Pandemic
Authors: Sinadia Alfrits Roul
Published: October 2022

Abstrak            Penelitian ini dilakukan untuk menilai kualitas kegiatan belajar mengajar virtual di universitas selama pandemi COVID-19. Secara spesifik, ini bertujuan untuk mendeskripsikan jenis perangkat pendukung TIK yang digunakan mahasiswa, jenis jaringan yang mereka gunakan, kualitas koneksi internet yang mereka miliki, persepsi mereka tentang kualitas kegiatan belajar mengajar virtual.  Penelitian ini juga mempelajari pengaruh perbedaan penggunaan perangkat TIK dan kualitas koneksi internet terhadap kualitas pembelajaran virtual. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan analisis statistik deskriptif dan inferensial.  Pengumpulan data dilakukan melalui kuesioner virtual yang diisi oleh 71 responden. Hasil penelitian menunjukkan bahwa pembelajaran virtual akan efektif jika mereka menggunakan desktop / laptop dan smartphone secara bersamaan saat melakukan aktivitas pembelajaran virtual. Akibat lainnya adalah semakin baik kualitas koneksi internet yang mereka miliki maka semakin efektif pula kegiatan belajar virtual mereka. Berdasarkan persepsi mereka, baik pengajaran maupun pembelajaran virtual berjalan dengan baik.  Kata kunci—kualitas pembelajaran, pembelajaran virtual, pembelajaran daring  Abstract            This study was conducted to assess the quality of the virtual teaching and learning activities at a college during pandemic COVID-19 as perceived by its students.  Specifically, it aimed to describe the types of ICT supporting devices students used, types of the network they used, quality of internet connection they had, and their perceptions on the quality of virtual teaching and learning activities.  It also studied the effect of different use of ICT devices and internet connection quality toward virtual learning quality.  This was a quantitative study using descriptive and inferential statistical analyses.  The data were gathered through an online questionnaire filled by 71 respondents.  The results showed that virtual learning would be effective if they used both desktops/laptops and smartphones altogether when doing virtual learning activities.  Another result was the better the quality of the internet connection they had; their virtual learning activities were more effective.  Based on their perceptions, the virtual teaching and learning activities were well conducted.  Keywords—learning quality, virtual learning, online learning
Sistem Pendukung Keputusan Penentuan Lokasi Usaha Strategis Bagi Pelaku UMKM di Kota Padang Menggunakan Metode Multi Factor Evaluation Process (MFEP)
Authors: Ikhlas Muhammad , Jafnihirda Lika
Published: October 2022

Dalam dunia bisnis, banyak sekali faktor yang mempengaruhi sukses atau tidaknya sebuah usaha, salah satu diantaranya adalah lokasi. Pemilihan lokasi seringkali menjadi kendala bagi pelaku usaha, terutama yang memiliki modal kecil seperti UMKM (Usaha Mikro Kecil dan Menengah). Untuk itu perlu adanya survey terhadap lokasi usaha yang akan dipilih agar sesuai dengan jenis usaha yang akan dijalankan. Dengan menerapkan metode Multi Factor Evaluation Process (MFEP), berdasarkan faktor-faktor yang ada kita dapat mementukan lokasi usaha yang strategis dari beberapa alternatif yang tersedia. Setiap faktor diberikan nilai bobot yang sesuai dengan jenis usahanya. Namun, tidak semua jenis usaha memiliki bobot faktor yang sama. Sehingga dengan adanya sistem pendukung keputusan ini dapat membantu pelaku UMKM dalam menentukan lokasi usaha yang strategis, terutama di wilayah Kota Padang. Sistem pendukung keputusan dengan metode MFEP ini diimplementasikan ke dalam bahasa pemrograman Visual Basic .NET dengan perancangan sistem dibantu dengan bahasa pemodelan UML (Unified Modeling Language).
Perancangan Sistem Informasi Organisasi Kemahasiswaan Berbasis Web pada Universitas Advent Indonesia Menggunakan Metode Agile Development (Studi Kasus: Universitas Advent Indonesia)
Authors: Hutauruk Amos Charlie , Pakpahan Andrew Fernando
Published: October 2022

Organisasi kemahasiswaan merupakan suatu tempat berkumpul bagi para mahasiswa yang memiliki kesamaan minat, kegemaran, dan kreativitas di dalam kampus. Organisasi mahasiswa atau yang biasa disebut sebagai Unit Kegiatan Mahasiswa (UKM) memiliki peranan penting bagi setiap mahasiswa untuk mengembangkan bakat di luar kegiatan perkuliahan. Penyebaran informasi yang dilakukan oleh setiap organisasi di Universitas Advent Indonesia (UNAI) saat ini belum dilakukan secara maksimal, persetujuan proposal dan laporan pertanggung jawaban belum terekam secara digital yakni masih menggunakan lembaran kertas. Oleh karena itu penulis ingin menganalisis serta merancang sebuah aplikasi sistem informasi organisasi kemahasiswaan berbasis web pada UNAI dengan menggunakan metode SDLC Agile Development. Dari penelitian yang telah dilakukan penulis dapat menyimpulkan bahwa (1) Penyebaran sistem informasi belum sepenuhnya dilakukan secara maksimal. (2)  Penulis merancang sebuah prototipe sistem informasi yang dapat digunakan untuk mempermudah organisasi mahasiswa di UNAI dalam mengelola informasi. (3) Seluruh warga UNAI dapat mengetahui organisasi mana yang masih aktif dan yang sudah tidak aktif.
Pemodelan Persamaan Struktural Pada Adopsi Mobile Banking Studi Kasus: Bsgtouch Bank Sulutgo
Authors: Walean Ronny , Talumantak Juhenwils
Published: October 2022

Kemajuan dalam teknologi telekomunikasi dan informasi memiliki dampak besar pada banyak sektor industri, termasuk sektor perbankan. Mobile banking kemudian menjadi pilihan nasabah dalam transaksi keuangan. Penelitian ini bertujuan untuk menganalisis penerimaan nasabah terhadap penggunaan layanan mobile banking dengan menggunakan pendekatan Technology Acceptance Model (TAM) yang dikembangkan oleh Davis (1989). Penelitian ini menganalisis 277 responden nasabah pengguna layanan BSGTouch dengan menggunakan metode kuantitatif dan teknik analisis data SEM PLS menggunakan aplikasi SmartPLS. Hasil penelitian ini menunjukan bahwa perceived ease of use dan perceived usefulness mempengaruhi attitude toward using pengguna, attitude toward using kemudian mempengaruhi behavioral intention, dan behavioral intention mempengaruhi responden actual use nasabah pengguna  mobile banking. Penelitian ini menjelaskan secara lengkap bagaimana setiap variabel dalam TAM saling berhubungan satu sama lain. Secara umum penggunaan TAM dalam menganalisis adopsi mobile banking bisa dibuktikan dalam penelitian ini. Kata kunci— Mobile Banking, SEM, Technology Acceptance Model
JOURNALYZ: An Android-Based Gamification of Bookkeeping Simulation
Authors: Lompoliu Erienika Meiling
Published: October 2022

Learning process often be a burden for students. Complex concepts in accounting can difficult be if not intimidating even for undergraduate students and gamification of that lesson can be a solution. Numbers of empirical studies has shown that, due to its unique approach, have positive effects for younger audience and could add another channel for students aside the existing conventional media. Journalyz is intended to be a gamified education for undergraduate students studying accounting and evaluating business transactions based on real-world examples. This program will assist students in developing a solid grasp of the business transactions of a merchandising and service firm as well as being acquainted with the many forms of transactional papers used in business. Furthermore, students will learn to assess transactions utilizing business documentation and record them on relevant accounts. The app is build for Android devices so it is handy and simple to be used anywhere.
Daya Tarik Marketplace bagi Generasi Z di Masa Pandemi COVID-19
Authors: Aseng Andrew Christian , Pandeirot Lanemey Brigitha
Published: October 2022

Perkembangan marketplace yang semakin pesat ditambah meningkatnya transaksi di marketplace karena pandemi COVID-19 serta proyeksi bahwa generasi Z (gen Z) akan berperan penting dalam perkembangan transaksi secara online membuat topik ini menarik untuk dipelajari. Penelitian ini bertujuan untuk mencari tahu apa yang menjadi daya tarik dari marketplace bagi gen Z terlebih di masa pandemi COVID-19. Penyusunan instrumen penelitian berdasarkan tinjauan literatur terkait dan wawancara intensif ke beberapa mahasiswa dari gen Z. Kuesioner dengan 34 butir pertanyaan disebarkan secara online kepada 374 gen Z. Data kemudian dianalisis menggunakan statistik deskriptif dan exploratory factor analysis. Hasil pemfaktoran diperoleh ada empat faktor daya tarik marketplace bagi gen Z pada masa pandemi ini, yaitu: faktor pengiriman dan jaminan keamanan, faktor ketersediaan barang dan popularitas, faktor kemudahan bertransaksi, dan faktor aksesibilitas. Beberapa saran dan rekomendasi diberikan sehubungan dengan hasil yang diperoleh kepada penyedia marketplace maupun gen Z dan juga untuk penelitian selanjutnya.Kata kunci— marketplace, gen Z, daya tarik, pandemi COVID-19.
Is there a post-COVID-19 increase in violence and aggressive behavior in Egypt or globally?
Authors: Ahmed Amr
Published: October 2022

Emerging data and reports from those on the front lines show that all types of violence against women and girls, particularly domestic violence, have increased since the outbreak of COVID-19. This is the COVID-19 Shadow Pandemic, and we need a global collaborative effort to stop it. Essential services, such as domestic violence shelters and helplines, have reached capacity as COVID-19 cases continue to strain health services. More needs to be done in COVID-19 response and recovery efforts to prioritize addressing violence against women. Everyone has a role to play, and UN Women is providing up-to-date information and funding vital programs to combat the Shadow Pandemic of violence against women during COVID-19. (1)a Villalpando JMG investigation following results was obtained from a comparison of the population with previous mental health disorders and COVID-19 to those without background disorders or COVID-19: Severe depression affected 27.58 percent versus 16.82 percent, severe anxiety affected 48.27 percent versus 17.75 percent, In and severe stress affected 27.58 percent versus 20.56 percent. Patients without COVID-19 had a high prevalence of mental health effects, which was increased in the population with long-term COVID syndrome and prior mental health disorders. (2)Na Zeng et al. conducted a meta-analysis for the study of long-term neuropsychiatric symptoms among recovered survivors.
A single-nucleotide variant on chromosome 5, rs10942942, residing within RASGRF2 is associated with the basal-like (triple negative) phenotype in human breast cancer, and black women display an allelic frequency imbalance at this site.
Authors: Mamoor Shahan
Published: October 2022

Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). Black women are disproportionately diagnosed with basal subtype or triple negative breast cancer for reasons that are not yet understood (3, 4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors from patients with basal or basal-like subtype breast cancer and integrated this with DNA sequence information aggregated from across earth to identify sites that are blindly associated with the basal subtype and that harbor imbalance of allelic frequency based on race. We identified a single nucleotide polymorphism, rs10942942, residing within RASGRF2 as among the most significant genetic differences in the tumors of patients with basal-like breast cancer. Moreover, allelic frequency at this site was significantly different between black women and white women. Analysis of patient survival data revealed that RASGRF2 primary tumor expression was correlated with distant metastasis-free survival in patients with normal-like breast cancer. Tumor expression of RASGRF2 was correlated with recurrence-free survival in black but not white women. Sequence variation in the RASGRF2 gene may be important in understanding differences in genetic background that favor development of basal subtype human breast cancer.