bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission
Authors: Imamura Yukio , Okuzumi Ayami , Yoshinaga Saki , Hiyama Akiko , Furukawa Yoshiaki , Miyasaka Tomohiro , Hattori Nobutaka , Nukina Nobuyuki
Published: June 2022

Synucleinopathies are neurodegenerative disorders including Parkinson disease (PD), dementia with Lewy body (DLB), and multiple system atrophy (MSA) that involve deposits of the protein alpha-synuclein (α-syn) in the brain. The inoculation of α-syn aggregates derived from synucleinopathy or preformed fibrils (PFF) formed in vitro induces misfolding and deposition of endogenous α-syn. This is referred to as prion-like transmission, and the mechanism is still unknown. In this study, we label α-syn PFF with quantum dots and visualize their movement directly in acute slices of brain tissue inoculated with α-syn PFF seeds. Using this system, we find that the trafficking of α-syn seeds is dependent on fast axonal transport and the seed spreading is dependent on endocytosis and neuronal activity. We also observe pharmacological effects on α-syn seed spreading; clinically available drugs including riluzole are effective in reducing the spread of α-syn seeds and this effect is also observed in vivo. Our quantum-dot-labeled α-syn seed assay system combined with in vivo transmission experiment reveals an early phase of transmission, in which uptake and spreading of seeds occur depending on neuronal activity, and a later phase, in which seeds induce the propagation of endogenous misfolded α-syn.
Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition
Authors: Pan Xuekang , Shan Huajian , Bai Jinyu , Gao Tian , Chen Bao , Shen Zhonghai , Zhou Haibin , Lu Huigen , Sheng Lei , Zhou Xiaozhong
Published: June 2022

Osteoarthritis (OA) is a highly prevalent and chronic disorder that is associated with a substantial social and economic burden. Itaconate, as an important regulator of cellular inflammation, is a metabolite synthesised by an enzyme encoded by immune-responsive gene 1. However, there are few studys regarding the effects of itaconate on OA. Here, we show the effect of the cell-permeable itaconate derivative 4-octyl itaconate (OI) on OA. OI attenuates the chondrocyte apoptosis induced by interleukin 1β (IL-1β) in vitro, indicating that OI protect chondrocytes against apoptosis. Moreover, OI ameliorates the chondrocyte autophagy inhibition induced by IL-1β via the inhibition of PI3K/AKT/mTOR signalling pathway. Finally, OI enhances autophagy and reduces cartilage degradation in a rat model of OA established by destabilization of medial meniscus (DMM). In summary, our findings reveal that OI is involved in regulating the progression of OA. The above results shed light on the treatment of OA.
A biphosphine copolymer encapsulated single-site Rh catalyst for heterogeneous regioselective hydroaminomethylation of alkenes
Authors: Zhao Kang , Wang Hongli , Wang Xinzhi , Cui Xinjiang , Shi Feng
Published: June 2022

A biphosphine copolymer catalyst with in situ encapsulated single-site Rh was developed and applied in heterogeneous hydroaminomethylation of alkenes, affording the corresponding amines in good to excellent regioselectivity and catalytic activity.
Configurational ligand isomerism in conjoined-cages
Authors: Dasary Hareesha , Sarkar Moumita , Chand Dillip Kumar
Published: June 2022

Isomeric coordination complexes of different configurations (hour-glass and double-decker) but prepared from regioisomeric tridentate ligands are described.
Highly efficient and robust aerobic co-oxidation of olefins and aldehydes over CoOx dispersed within hierarchical silicalite-1 zeolites
Authors: Li Chenhao , Pu Ning , Huang Kaimeng , Xia Changjiu , Peng Xinxin , Lin Min , Zhu Bin , Shu Xingtian
Published: June 2022

This work not only provides an efficient and green epoxidation route over robust catalysts with easily available O2 as the oxidant, but also systematically reveals the understanding of the corresponding structure–activity relationship for ROS transformation.
Efficient hydrodeoxygenation of guaiacol to phenol over Ru/Ti–SiO2 catalysts: the significance of defect-rich TiOx species
Authors: Wang Xinchao , Wang Zhuangqing , Zhou Leilei , Liu Yanchun , Yang Yinze , Zhang Liyan , Shang Zongling , Li Hui , Xiao Tingting , Zhang Chao , Zhao Fengyu
Published: June 2022

Under relatively mild conditions (240 °C and 0.4 MPa H2), Ru/Ti–SiO2 exhibited higher activity for C–O bond cleavage compared with both Ru/SiO2 and Ru/TiO2 catalysts, and achieved high guaiacol conversion (83.6%) and phenol selectivity (70.4%).
van der Waals epitaxy of transition metal dichalcogenides via molecular beam epitaxy: looking back and moving forward
Authors: Singh Deependra Kumar , Gupta Govind
Published: June 2022

van der Waals epitaxy of TMDCs and their applications.
Graphene fibre film/polydimethylsiloxane nanocomposites for high-performance electromagnetic interference shielding
Authors: Xu Lu , Lu Haohao , Dong Yubing , Fu Yaqin , Ni Qingqing
Published: June 2022

A graphene nanocomposite with a low permeability threshold and high electromagnetic interference shielding performance was prepared. Controlled surface density and configuration of the fillers adjusted the performance.
Activating bimetallic ZIF-derived polymers using facile steam-etching for the ORR
Authors: Wu Yanling , Li Miantuo , Ma Liping , Lu Minghui , Zhang Haijun , Qi Meili
Published: June 2022

An α-Fe2O3/Fe@NPC catalyst for the ORR is synthesized via a thermal shock reaction with precursors 1 and 2.
Enhancement of the catalytic activity of Suzuki coupling reactions by reduction of modified carriers and promotion of Pd/H2-PrxOysurface electron transfer
Authors: Wang Fu , Li Chunping , Xu Tong , Li Ying , Sun Yinghui , Bai Jie
Published: June 2022

Pd/H2-PrxOynanotubes were prepared by electrostatic spinning, high-temperature calcination and modified deposition–precipitation method, and exhibited high catalytic performance for Suzuki coupling reaction under mild conditions.
Physical development as per results produced by bioelectrical impedance analysis (BIA) for estimating body composition depending on sex and age of schoolchildren aged 7–16 years
Authors: Shtina Irina , Valina Svetlana , Ustinova Olga
Published: June 2022

The research goal was to estimate physical development of schoolchildren as per data of bioelectrical impedance analysis (BIA) of body composition depending on their sex and age. Physical activity (PA) is an important factor in providing physical welfare of schoolchildren and this makes the present research relevant today. We examined 604 schoolchildren. At present a share of schoolchildren who have physical activity with its duration corresponding to the WHO recommendations doesn’t exceed 45%. We established an inverse correlation between a share of Skeletal muscle mass (SMM) and age. The determination coefficient which showed a variability a share of SMM and fat mass depending on a combination of PA regularity and duration didn’t exceed 0.06. It grew up to 0.19 after we assessed influence exerted by schoolchildren’s age on the absolute value of BMM share. A contribution made by age to this parameter was by 8.0 times higher among boys than among girls. We detected an age-specific decline in a probability of lower SMM share which was by up to 11.8 times lower among boys than among girls. These established sex-related differences in probable age-specific decrease in physical development make BIA a more valuable source of information for motivating schoolchildren to have more PA and improve their health.
The use of therapeutic plasmapheresis in preventive and sports medicine
Authors: Gilmutdinova Ilmira , Kudryashova Irina , Kostromina Elena , Yafarova Inessa , Gilmutdinov Rinat , Kaverina Irina , Isaev Andrey , Moskalev Alexey
Published: June 2022

Maintenance of active longevity, preservation of physical activity, and prevention of decreased mobility associated with injury or age of patients are among the most urgent tasks for modern healthcare. The suppression of pathological processes and activation of defense systems at the cellular and organismal levels are the main routes for solving these problems. Several initial anti-aging therapy approaches are detoxification, rheocorrection, and immunocorrection. In these areas, methods of extracorporeal hemocorrection, in particular, therapeutic plasmapheresis, are effective. This study aimed to evaluate the effectiveness of hardware plasmapheresis with albumin compensation by assessing the dynamics of circulating age-related biomarker levels in randomly selected patients. Twenty human subjects of both sexes aged 40–55 years with an increase in one or more aging-related biomarkers participated in this study. The patients were randomly divided into two groups with ten people each. Patients from Group 1 underwent therapeutic plasmapheresis with albumin replacement (four procedures with a 2-day interval). Patients from Group 2 were offered plasmapheresis treatment with saline replacement. The levels of aging-related biomarkers were determined in the blood of patients before and 30 days after starting treatment. Preliminary data showed that plasmapheresis with albumin replacement in randomly selected male and female patients was accompanied by normalization of the selected aging biomarkers. Thirty days after the start of the plasmapheresis treatment, a decrease in both biological and phenotypic age was determined. Further studies are needed to investigate the effects of nutritional factors on aging biomarkers with and without plasmapheresis treatment. Based on the obtained results, recommendations will be made on the use of plasmapheresis in preventive and sports medicine. The use of this method will help reduce the biological age of patients and, as a result, reduce the risks of developing age-related diseases and disabilities and contribute to prolonging life and improving its quality.
Peculiarities of value-rational grounds of dispositions of actors of physical-educational space of a regional university in the new reality
Authors: Babintsev Valentin , Serkina Yana , Goncharuk Yaroslav , Goncharuk Svetlana , Gaidukova Galina
Published: June 2022

The paper considers the problem of modern specificity of value-rational grounds of dispositions of actors of physical-educational space of regional universities. The empirical basis of the work results from sociological research conducted in 2019-2020 by questionnaire survey of the subjects of physical-educational space of universities in the Belgorod, Kursk, and Lipetsk regions (the Central Black Earth regions of Russia, which have close characteristics). It is argued that despite the importance of the value of physical development, the representatives of different groups of actors of physical-educational space of regional universities are included in this activity to a different extent. The main reasons for the differences are connected with the peculiarities of comprehending the value of physical development and determining the model of behavior within the physical-educational space on this basis. Two models of attitude towards this value are distinguished: the model of rational efficiency, which is used by the most of the administrators, professors and researchers; and the combined model, which composes the rationality of survival and imaginative rationality, which is most typical of students.
The retrospective comparison of Olympic rowing results considering weather
Authors: Pomerantsev Andrey , Biriukov Vladislav , Ezhova Nadezhda , Shklyarov Vladimir , Bespyatkin Vladimir
Published: June 2022

The purpose of the paper is comparing the rowing results in different aeroand hydrodynamics conditions. We analyzed the winners’ results of the single sculls (1x) men finals at the Olympic Games regattas from Sydney to Tokyo. We used precise weather hour diary and satellite maps to reconstruct the exact weather race conditions.We found data on the sport results and parameters of the rowers on the official websites of the competitions and the WorldRowing website. The created physical and mathematical model of the weather conditions influence is based on the second law of mechanics and includes 22 variables which characterise environment and features of the rowing biomechanical system. The physical and mathematical model was implemented in the form of a computer application. The computer application made it possible to accurately assess the preparedness of athletes by clearing the distance time off the environment influence. The pure characteristic time allowed comparing the results obtained in different weather conditions. Calculation reveals that the weather conditions have an effect on race time significantly. The weather influence on Olympic race was in the range of - 10.10 to +5.94 seconds. The presented approach allows to register world and Olympic records for the first time in rowing history.
Features of the organization and holding of the “Ready for Labor and Defense” Festivals for students and teachers of the university
Authors: Bobkov Vitalii Viktorovich , Antonova Irina Nikolaevna , Titushina Natalia Viktorovna , Akimova Elena Mikhailovna , Garina Evgeniia Vladimirovna , Alatyreva Iana Alekseevna
Published: June 2022

This study aims to determine the effectiveness of multi-day festivals “Ready for Labor and Defense” (GTO) at the university for students and teachers, as well as the feasibility of creation of educational and independent classes in physical education in accordance with the tests of the All-Russian physical culture and sports complex GTO for participants of the VI-XI stages. Analysis of the survey data of the 1st year students shows that 23% of them have experience in performing tests under the state program of testing physical fitness of the population “Ready for Labor and Defense”. The polling of 4th year students shows that less than 3% of them took part in the GTO tests during their studies at university. This study included 1363 men and women belonging to the VI-XI stages of the All-Russian Physical Education and Sports Complex GTO. Students were offered an elective course (optional) in physical education. During the classes, they were trained to meet the standards included in the GTO program. The classes were based on the principle of circuit training and the method of continuous exercising. 82% of students and 100% of teaching staff of the Department of Physical Education of the Russian State University for the Humanities took part in testing of the complex “Ready for Labor and Defense” held during the “Week of Health”. 23% of the participants of the GTO Festival received gold, silver and bronze badges. The GTO Festivals hold at universities helps solve the problem related to the logical transition from the training (gym) to the GTO Testing Centers, since both the preparation and direct performance of the physical fitness tests are carried out at the university campus.
Analysis of the competitive activity of qualified judoists in standing wrestling
Authors: Mavropulo Ol’ga , Demyanova Ludmila , Ryzhkin Nikolai , Usova Irina , Aldoshin Andrew
Published: June 2022

This article considers the features of the use of techniques in wrestling in a standing position by judoists in the pre-competitive period. The effectiveness of the use of various combat tactics is being discussed. The results of competitions of international level, world level and European championships are analyzed. Identified are the main areas of training which are used to plan preparation for competitions.
Attitude to health as an indicator of basic needs satisfaction among overweight female teachers
Authors: Minakhmetova Albina , Pyanova Ekaterina , Martynova Victoria
Published: June 2022

In modern conditions, the study of self-attitude and attitude to health among middle-aged overweight women is relevant in practical terms, since it is an important condition for full psychological health. This paper aims to study attitude to health as an indicator of basic needs satisfaction among overweight teachers. Body mass index, attitude to health, and satisfaction of needs were taken as the major parameters for the analysis of empirical materials. The study involved fifty female teachers aged from 31 to 34. It was revealed that the system-forming component of overweight women is “the need for safety”. The research results can be used by psychologists and fitness instructors in the development of correctional approaches, educational programs on a healthy lifestyle, training sessions, weight management programs, as well as during the consulting of female teachers.
Influence of motor activity and polymorphism I/D of ACE on the affinity of oxygen for hemoglobin
Authors: Dautova Albina , Khazhieva Evgenia , Isaeva Ekaterina , Khabibulinna Ilmira , Shamratova Valentina
Published: June 2022

The influence of rs4646994 polymorphism of the ACE gene on the affinity of oxygen for hemoglobin among young men with different levels of physical activity has been studied. 245 young men aged 20-22 years were included in the study. All young men were divided into three groups depending on their motor activity: low (LMA), average (AMA) and high (HMA). SatO2, pO2, pCO2, p50 and HbO2 were analyzed in capillary blood of all examined young men. It was found out that I/I genotype of the ACE gene is associated with a decrease in the affinity of oxygen for hemoglobin both in LMA (p=0.022) and in HMA (p=0.000096). The intensification of physical activity among I/D and D/D genotypes is accompanied by an increase in the level of hemoglobin oxygenation in blood, while the I/I genotype with part of HbO2 does not change depending on motor activity. These features can be explained by the shift of the oxygen dissociation curve to the left among young men with the *D allele genotype, with an increase in physical activity. On the contrary, the I/I genotype of the ACE gene have efficient oxygen extraction to tissues, regardless of the level of motor activity compared to the D/D genotype.
Analysis of approaches to waste management of pig farms
Authors: Monastyrskiy D I , Kulikova M A , Zemhenko G N , Kolesnikova T A , Andreeva A N , Novikova D A
Published: June 2022

This paper aims to analyze effective approaches to waste management in agro-industrial cluster. It considers the studies confirming the relevance and importance of the development of technologies for processing and recycling of waste from the agro-industrial cluster, and, in particular, waste from pig farms. The methods of system analysis, information synthesis, statistical data analysis were used to identify the existing problems. The period from 2000 to 2020 was considered. The most popular directions and production branches have been identified. Quantitative analysis of scientific works on recycling and disposal of waste of agro-industrial cluster was carried out. Based on the data obtained, graphs were built, comparisons were made, conclusions were drawn about the demand for the development of resource-saving technologies, and waste recycling. Based on the analysis of the existing approaches, the authors proposed a cluster form of organization and waste management.
Problems of the Russian forest industry management and innovative development
Authors: Dayneko Dennis
Published: June 2022

The role in the economy and the structure of the forest industry are presented. The key problems of forest management and innovative development of the forest industry in Russia are highlighted. Namely, these are the following: 1) production and technological; 2) natural and ecological; 3) institutional and organizational; 4) problems of forest protection and reforestation. The ways of their solution are proposed for the forest industry of Russia. The innovative development of the forest industry of Russia is discussed. The implementation of the Forest innovation system is suggested for the sustainable forest industry management and based on the feedback of the experts in the forest industry.
Contributions of Information and communication technologies to industrialization of additive manufacturing
Authors: Kaci Abdelhak , Hamaci Samir , Elabassi Ikram , Chelouah Rachid
Published: June 2022

Additive manufacturing is in clear progress in the field of civil engineering construction, essentially boosting by the development of new information and communication technologies. For better industrialization of the use of this technique, in-situ control of products manufactured along the production line is a major issue. In this work we were able to supervise the quality of printed object along the process by comparing the target values and those measured by image processing obtained by a camera installed in the printing device. We have developed a program that allows us to measure the deformations of the different layers and thus to assess the difference between the values of the target ratings and those achieved. This deviation is defined as a criterion for validating piece conformity and can also be used to adapt the process parameters.
Development of Blue-green infrastructure framework to restore nallahs (dirty drains) to nadis (streams), in India
Authors: Pusalkar Vandana , Swamy Vimala , Shivapur Anand
Published: June 2022

The rivers and streams serve as important life support systems for helping in recharging the aquifers and regulating the hydrological cycle besides providing habitats and breading grounds for birds, fish and aquatic life. However, these are always becoming targets of adverse effects of development around the streams particularly in urban areas due to presence of human activities like urbanization and climate change. As a result of these activities, most of the urban streams have got degraded due to encroachment, siltation discharge of domestic sewage, surface drainage caring sand and silt and other chemical pollutants. Literature review is conducted to study how resilience and ecosystem services can play important role in climate change adaptation and to keep balance between nature and society. This review paper is to analyse the Green Infrastructure (GI) and the recent Blue-Green Infrastructure (BGI) are the multidisciplinary approaches to combat the negative impact of urbanization and climate change on urban streams and revive the condition totally. Identification of the need of development of Blue-Green infrastructure framework to transform nallahs (dirty drains) to nadis(Streams) in India.
Les attendus d’une approche d’économie comportementale pour les décisions individuelles face à la pandémie de COVID-19 : succès et déceptions
Authors: Blayac Thierry , Dubois Dimitri , Duchene Sébastien , Nguyen-Van Phu , Rafaï Ismaël , Ventelou Bruno , Willinger Marc
Published: June 2022

Dans le cadre du premier appel à projet « Flash-COVID-19 » de l’Agence nationale de la recherche, nous avons mobilisé des méthodes récentes de l’économie comportementale afin de mieux comprendre les décisions des individus face à la crise sanitaire due à la pandémie de COVID-19 (coronavirus disease 2019) et d’identifier les paramètres pouvant influencer le respect des mesures sanitaires. Cet article introduit brièvement l’économie comportementale, présente un compte rendu des attendus du projet CONFINOBS (Observance et observation des mesures barrières et du confinement : une approche d’économie comportementale) et de ses méthodes, puis il propose une synthèse des résultats obtenus.
Séquence du génome : la fin du commencement
Authors: Jordan Bertrand
Published: June 2022

Two decades after its original publication, a new human genome sequence has just been published. Far from being an incremental improvement, it is at last really complete, covering each chromosome from one end to the other, with full elucidation of repeated sequences and an extremely low error rate. This is a major advance that tremendously increases our knowledge of our genome and will lead to important scientific and clinical developments.
Einstellung der Zahn-Lippen-Relation im parodontal
geschwächten Gebiss mittels Intrusion der Front
Authors: Knocks Larissa , Klenke Daniela , Meyer-Marcotty Philipp
Published: June 2022

Die Parodontitis zählt als chronisch entzündliche Erkrankung des
Zahnhalteapparates zu einer der am häufigsten bakteriell,
inflammatorisch bedingten Erkrankungen im Erwachsenenalter. Als eine zu mehr als
50% auftretende Komorbidität ist die pathologische
Zahnwanderung, die u. a. mit funktionellen Einbußen
(insuffizienter Mundschluss, Sprache, Ästhetik) vergesellschaftet ist.
Nach einer parodontologisch/kieferorthopädischen Therapie wird
eine Wiederherstellung der Funktion und die Verbesserung der knöchernen
Situation der bewegten Zähne erreicht.

In der Diagnostik bieten neue Methoden wie die Stereophotogrammetrie
hervorragende Möglichkeiten die Bildgebung non-invasiv zu erweitern und
den Behandlungsverlauf und die damit verbundene Verbesserung der
Weichteilsituation zu beurteilen.

Für eine erfolgreiche Therapie ist die Intrusion und Retrusion der
betroffenen Frontzähne mit individuell angepasster Biomechanik
notwendig. Dabei sind zu Beginn der kieferorthopädischen Therapie
entzündungsfreie parodontale Verhältnisse obligat. Mit Hilfe von
segmentierten Apparaturen und skelettaler Verankerung ist eine kontrollierte,
nebenwirkungsarme Intrusion, mit dem Ziel ein funktionelles und dentofaziales
Gleichgewicht zu erreichen, schon in der Nivellierungsphase möglich.

Für eine erfolgreiche Therapie und eine gute Prognose mit Verbesserung
bzw. Erhalt der Mundgesundheit ist eine interdisziplinär
parodontlogisch/kieferorthopädische Versorgung notwendig.
Gimme Shelter – Strahlentherapie eines Rezidivs eines
Zungengrundkarzinoms bei einem geriatrischen Patienten
Authors: Holzhauer Peter , Stoll Günther
Published: June 2022

Hier vorgestellt wird der Krankheits- und Behandlungsverlauf eines bei
Erstdiagnose 91-jährigen Patienten mit bereits metastasierendem
Zungengrundkarzinom. Initial erfolgt eine Radiochemotherapie, die intensiv durch
eine supportive komplementärmedizinische Behandlung begleitet wurde.
Drei Jahre nach der erfolgreichen Primärtherapie zeigte sich ein lokales
Rezidiv mit diversen Lymphknotenmetastasen. Der Patient wurde erneut bestrahlt.
Wegen des hohen Alters und des reduzierten Allgemeinzustands wurde auf eine
Chemotherapie verzichtet. Von Seiten des Patienten bestand ein dringender
Behandlungswunsch.
Die Rolle des Mikrobioms in der gastrointestinalen
Karzinogenese
Authors: Vasapolli Riccardo , Macke Lukas , Schulz Christian
Published: June 2022

Unter dem Begriff „menschliches Mikrobiom“ wird der Komplex aus
Mikroorganismen – Bakterien, Viren, Pilze, Protozoen und Archaeen
–, welche die Oberflächen, Gewebe und Flüssigkeiten des
menschlichen Körpers besiedeln, zusammengefasst. Sie haben eine
offensichtliche Rolle bei der Kanzerogenese und mit der Verbreitung neuer
Hochdurchsatz-Sequenzierungsmethoden ist die Untersuchung dieser mikrobiellen
Gemeinschaften wesentlich einfacher geworden. Diese Übersichtsarbeit
beschreibt die aktuell verfügbare Evidenz über die Rolle des
Mikrobioms bei der gastrointestinalen Karzinogenese.
Therapie maligner Lymphome
Authors: Hentrich Marcus
Published: June 2022

Ziel Ziel dieses Artikels ist es, einen aktuellen Überblick
über gegenwärtige Standards und aktuelle Entwicklungen in der
Therapie maligner Lymphome zu geben.

Material und Methoden Nicht-systematische Übersicht über
die Therapie wichtiger Lymphom-Entitäten unter Berücksichtigung
aktueller Leitlinien.

Ergebnisse Patienten mit aggressiven B-Zell-Lymphomen sowie
Hodgkin-Lymphomen werden mit kurativem Therapieziel behandelt. Therapiestandard
des diffusen großzelligen B-Zell-Lymphoms sind 6–8 Zyklen
R-CHOP. In Abhängigkeit vom internationalen Prognose-Index sind
Modifikationen dieser Therapie möglich. Im Falle eines frühen
Rezidivs wird der bisherige Standard einer Hochdosischemotherapie (HDCT) mit
autologer Stammzelltransplantation (ASCT) zukünftig durch eine Therapie
mit CAR-T-Zellen abgelöst werden. Eine Stadien-adaptierte Therapie des
Hodgkin-Lymphoms führt zu sehr hohen Heilungsraten, die auch in
fortgeschrittenen Stadien bei ca. 90% liegen. Jüngere Patienten
mit Rezidiv erhalten eine HDCT mit ASCT. Die Verfügbarkeit des
Antikörper-Wirkstoff-Konjugates Brentuximab Vedotin sowie der
Anti-PD1-Antikörper Nivolumab und Pembrolizumab haben die
Rezidivtherapie des Hodgkin-Lymphoms in den letzten Jahren erheblich bereichert.
Indolente Lymphome sind durch langsames Wachstum, längere stabile
Krankheitsphasen und meist lange Überlebenszeiten der Patienten
charakterisiert. Die Therapie des häufigsten Vertreters der indolenten
Lymphome, dem follikulären Lymphom, erfolgt mit einer Kombination aus
einem gegen CD20-gerichteten Antikörper und mit z. B. CHOP oder
Bendamustin, worunter lange progressionsfreie Zeiten erreicht werden.

Diskussion und Schlussfolgerung Die Therapie maligner Lymphome ist in
stetem Wandel. Der Einsatz verschiedener Immuntherapien habt in den letzten
Jahren zu einer Verbesserung der Therapieergebnisse geführt.
Ausgewählte Mikronährstoffe in der onkologischen
Intervention – ein Update
Authors: Gröber Uwe , Holzhauer Peter , Kisters Klaus
Published: June 2022

Je nach Tumorentität und Geschlecht supplementieren bis zu 90%
der Krebspatienten antioxidative und immunrelevante Mikronährstoffe,
häufig ohne das Wissen des behandelnden Arztes. Die Gründe
für die Inanspruchnahme komplementärmedizinischer Therapien sind
vielfältig, sie sind meist in einem patienteneignen, salutogenetisch
orientierten Konzept zu Gesundung, Heilung und Bewältigung der
Krebserkrankung sowie zur onkologischen Therapie zu finden. Aus Sicht der
Patientinnen sind Aspekte mit hoher Priorität die Wahrung der Autonomie,
die Verwirklichung einer Selbstbeteiligung und die Optimierung der Resilienz in
einer kritischen, oft bedrohlichen Lebensphase, die es zu bewältigten
gilt. Komplementäre Maßnahmen werden sowohl in der Akuttherapie
als auch in der Nachsorge eingesetzt. Die Sicherheit und Kompatibilität
der vielfältigen komplementären Maßnahmen mit der
konventionellen Tumortherapie sind von größter Bedeutung.
Onkologisch tätige Ärzte sollten daher über die aktuelle
Bedeutung von Vitamin D, Selen, Omega-3-Fettsäuren und anderen
(Mikro)nährstoffen sowie potenziellen Interaktionen mit der
Krebstherapie informiert sein.
Physical and Technical Demands and Preparatory Strategies in Female
Field Collision Sports: A Scoping Review
Authors: Dane Kathryn , Simms Ciaran , Hendricks Sharief , West Stephen W. , Griffin Steffan , Nugent Frank J. , Farrell Garreth , Mockler David , Wilson Fiona
Published: June 2022

Women’s participation in field collision sports is growing worldwide.
Scoping reviews provide an overview of scientific literature in a developing
area to support practitioners, policy, and research priorities. Our aim is to
explore published research and synthesise information on the physical and
technical demands and preparation strategies of female field collision sports.
We searched four databases and identified relevant published studies. Data were
extracted to form (1) a numerical analysis and (2) thematic summary. Of 2318
records identified, 43 studies met the inclusion criteria. Physical demands were
the most highly investigated (n+=+24), followed by
technical demands (n+= 18), tactical considerations
(n+=+8) and preparatory strategies (n=1). The
key themes embody a holistic model contributing to both performance and injury
prevention outcomes in the context of female field collision sports. Findings
suggest a gender data gap across all themes and a low evidence base to inform
those preparing female athletes for match demands. Given the physical and
technical differences in match-demands the review findings do not support the
generalisation of male-derived training data to female athletes. To support key
stakeholders working within female field collision sports there is a need to
increase the visibility of female athletes in the literature.
Treatment and Bleeding Complications of Cancer-Associated Venous Thromboembolism: A Korean Population-Based Study
Authors: Kim Sang-A , Lee Ju Hyun , Lee Ji Yun , Hwang Hun-Gyu , Kim Yang-Ki , Yhim Ho-Young , Hong Junshik , Lee Jeong-Ok , Bang Soo-Mee
Published: June 2022

Objectives This study investigated the treatment pattern and the rate of bleeding complications in real-world practice in cancer-associated venous thromboembolism (CT) patients.

Methods We used the Korean Health Insurance Review and Assessment Service database (2014–2018). Among patients with venous thromboembolism, patients with concomitant malignancy diagnostic codes were categorized as CT, while all others were categorized as non-CT. Treatments were categorized as direct oral anticoagulant (DOAC), parenteral anticoagulant (PAC), warfarin, and mixed anticoagulants.

Results We identified 27,205 CT and 57,711 non-CT patients. DOACs were the most frequently used anticoagulants. The proportion of patients treated with PAC was higher in CT than in non-CT patients (35.7 vs. 19.5%; p < 0.01). In CT, the cumulative incidence of any/major bleeding was higher with DOAC (8.1%/3.9%) than with PAC (7.5%/3.2%; p = 0.04 and 0.01, respectively). However, there was no difference in major bleeding when compared with warfarin (p = 0.11) or mixed anticoagulants (p = 0.94). Overall, gastrointestinal (GI) cancer patients showed higher risks of bleeding. The cumulative incidence of major GI bleeding was higher with DOAC than with PAC (4.9 vs. 3.0%; p < 0.01), while there was no difference compared with warfarin (p = 0.59) or mixed anticoagulants (p = 0.80). Major bleeding with each DOAC showed no difference among entire CT (p = 0.94), GI cancer (p = 0.27), and genitourinary cancer (p = 0.88) patients.

Conclusion Five years after their introduction into clinical practice, DOACs have become the most prescribed anticoagulant in Korea. In our patient population, bleeding complications occurred more frequently in CT than in non-CT, especially in patients treated with DOACs.
Identification of Nrf2 Activators from the Roots of Valeriana officinalis
Authors: Afzal Sualiha , Zhou Xian , Or King , Raju Ritesh , Münch Gerald
Published: June 2022

Various age-related chronic diseases have been linked to oxidative stress. The cellular antioxidant response pathway is regulated by the transcription factor nuclear erythroid factor 2.
Therefore, plant-derived nuclear erythroid factor 2 activators might be useful therapeutics to stimulate the bodyʼs defense mechanisms. Our study focused on the discovery of potent nuclear
erythroid factor 2 activators from medicinal plants. Initially, a variety of medicinal plant extracts were screened for nuclear erythroid factor 2 activity using a nuclear erythroid factor 2
luciferase reporter cell line. Among these, Valerian (Valeriana officinalis) root was identified as a potent candidate. Sequential extraction and bioassay-guided fractionation led to
the isolation of four nuclear erythroid factor 2-active compounds, which were structurally identified by NMR and LC/HRMS as the known compounds isovaltrate, valtrate, jatamanvaltrate-P, and
valerenic acid. These four compounds were then tested in relevant biological assays. Firstly, their effects on the expression of glutathione S-transferase, glutamate–cysteine ligase
catalytic subunit, glutathione peroxidase, and heme oxygenase 1 were determined in HepG2 cells. Glutathione S-transferase P1 and glutamate–cysteine ligase catalytic subunit were upregulated
by isovaltrate, valtrate, and jatamanvaltrate-P, while heme oxygenase 1 was upregulated by isovaltrate, jatamanvaltrate-P, and valerenic acid. The four compounds also increased the levels of
glutathione and its metabolite, CysGly. As glutathione aids in the detoxification of hydrogen peroxide, cytoprotective effects of these four nuclear erythroid factor 2 activators against
hydrogen peroxide toxicity were investigated, and indeed, the compounds significantly improved cell survival. This study provides evidence that four valepotriates from the roots of
V. officinalis are activators of nuclear erythroid factor 2-mediated antioxidant and detoxification pathways. Our data might expand the medical use of this plant beyond its current
application as a sleep aid.
The Curing Coma Campaign and the Future of Coma Research
Authors: Olson DaiWai M. , Hemphill J Claude , Provencio J Javier , Vespa Paul , Mainali Shraddha , Polizzotto Len , Kim Keri S. , McNett Molly , Ziai Wendy , Suarez Jose I. ,   the Curing Coma Campaign Collaborators
Published: June 2022

Recovery from coma or disordered consciousness is a central issue in patients with acute brain injuries such as stroke, trauma, cardiac arrest, and brain infections. Yet, major gaps remain in the scientific underpinnings of coma and this has led to inaccuracy in prognostication and limited interventions for coma recovery. Even so, recent studies have begun to elucidate mechanisms of consciousness early and prolonged after acute brain injury and some pilot interventions have begun to be tested. The importance and scope of this led in 2019 to the development of the Curing Coma Campaign, an initiative of the Neurocritical Care Society designed to provide a platform for scientific collaboration across the patient care continuum and to empower a community for purposes of research, education, implementation science, and advocacy. Seen as a “grand challenge,” the Curing Coma Campaign has developed an infrastructure of scientific working groups and operational modules, along with a 10-year roadmap.
Functional Muscle Transfer after Oncologic Extremity Resection
Authors: Hassan Abbas M. , Tesfaye Eliora A. , Rashiwala Abhi , Roubaud Margaret J. , Mericli Alexander F.
Published: June 2022

Background Functional muscle transfer (FMT) can provide wound closure and restore adequate muscle function for patients with oncologic extremity defects. Herein we describe our institutional experience with FMT after oncological resection and provide a systematic review and meta-analysis of the available literature on this uncommon procedure.

Methods A single-institution retrospective review was performed, including all patients who received FMT after oncological resection from 2005 to 2021. For the systematic review and meta-analysis, PubMed, Cochrane, Medline, and Embase libraries were queried according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines; results were pooled, weighted by study size, and analyzed.

Results The meta-analysis consisted of seven studies with 70 patients overall, demonstrating a mean Medical Research Council (MRC) score of 3.78 (95% confidence interval: 2.97–4.56; p < 0.01). The systematic review included 28 studies with 103 patients. Receipt of adjuvant chemotherapy was associated with significantly lower mean MRC score (3.00 ± 1.35 vs. 3.90 ± 1.36; p = 0.019). Seventy-four percent of the patients underwent free FMT, with the most common donor muscle being the latissimus dorsi (55%). The flap loss rate was 0.8%. Neoadjuvant chemotherapy (p = 0.03), radiotherapy (p = 0.05), pedicled FMTs (p = 0.01), and a recipient femoral nerve (p = 0.02) were associated with significantly higher complication rates. The institutional retrospective review identified 13 patients who underwent FMT after oncological resection with a median follow-up time of 21 months (range: 6–74 months). The most common tumor necessitating FMT was undifferentiated pleomorphic sarcoma (77%), and the most common donor muscle was the latissimus dorsi (62%). A high body mass index was associated with prolonged neuromuscular recovery (R = 0.87, p = 0.002).

Conclusion FMT after oncological resection may contribute to improved extremity function. Careful consideration of risk factors and preoperative planning is imperative for successful FMT outcomes.
Quad Fever in a Case of Cervical Cord Injury—A Rare Case Report
Authors: Ali Sheena , Ganesan Duraisamy , Sundaramoorthy Varun
Published: June 2022

By definition, “quad fever” is an extreme elevation in body core temperature beyond 40.8°C (105.4°F) in a patient with spinal cord injury. This type of central nervous system hyperpyrexia is seen in spinal cord injury patients, particularly those with high cervical spine injury with quadriplegia. However, it has also been described in paraplegics with a mid- or higher level thoracic spine injury. The incidence of “quad fever” is rare, with the highest reported temperature being 44°C (111.2°F) with chronicled fatal outcomes.

Though the use of antipyretics is generally efficacious, they are considerably ineffective in treating the hyperpyrexia seen in this type of severe central autonomic thermodysregulation.

Here, we present a case of high cervical spine injury in a 24-year-old male. The trauma resulted in a C3–5 level cord contusion with incomplete quadriplegia (ASIA [American Spinal Cord Injury Association Impairment Scale] grade B). The patient developed high grade fever of 106°F within a week of admission postoperatively.

Pancultures were negative and the wound was clean. Despite treatment with higher antibiotics and an infection disease specialist's consult, no obvious etiology was found. Drug-induced fever and thyroid function tests were excluded in other less-common causes.

Based on the diagnosis of exclusion, “quad fever” was inferred as the cause. He had other signs of autonomic instability during the episodes such as bradycardia with hypotension.

Our patient showed an almost early response to treatment to betablockers and antipsychotics after failure to respond to antibiotics, mechanical hypothermia, and antipyretics.
Fibrin Sealants Do Not Reduce the Rate of Seroma Formation in Postmastectomy Breast Reconstruction: A Systematic Review and Meta-analysis
Authors: Massada Karen E. M. , Wu Meagan , Webster Theresa K. , Panichella Juliet , Coronado Michael C. , Talemal Lindsay , Elmer Nicholas , Araya Sthefano , Brebion Rohan , Baltodano Pablo A. , Patel Sameer A.
Published: June 2022

Background Breast reconstruction using deep inferior epigastric perforator (DIEP) and latissimus dorsi (LD) flaps following mastectomy are associated with seroma formation, most commonly at the donor site. We sought to perform an updated systematic review and meta-analysis on the effects of fibrin sealant on donor-site complications following DIEP and LD flap breast reconstruction.

Methods A comprehensive literature search was conducted (March 2021) in PubMed, OVID, and Cochrane databases. Articles analyzing the efficacy of fibrin glue in reducing donor-site morbidity in DIEP and LD breast reconstruction were included. The outcomes assessed were seroma formation and duration of drainage.

Results A total of 17,265 articles were screened, and 9 articles were selected for analysis, which comprised 632 surgical sites in 611 patients. Comparing fibrin glue and quilting to quilting alone showed no significant difference in seroma formation (pooled risk ratio [RR]: 0.51; 95% confidence interval [CI]: 0.12, 2.25). Similarly, comparing fibrin glue alone to no fibrin glue showed no significant difference in seroma formation (pooled RR: 1.03; 95% CI: 0.66, 1.61) or duration of drain (pooled RR: −0.85; 95% CI: −4.09, 2.40); there was however a difference in duration of drain in those who received fibrin glue and quilting versus quilting alone (pooled RR: −2.13; 95% CI: −3.27, −0.99).

Conclusion The existing literature supports that the use of fibrin glue is not associated with a decrease in seroma formation in DIEP and LD flaps and is weakly associated with a reduction in the drainage duration only if used in conjunction with quilting.
Comparative Evaluation of Coronally Advanced Flap Procedure in Conjunction with Amniotic Membrane Versus Coronally Advanced Flap with Platelet-Rich Fibrin Membrane in Patients with Miller's Class I and II Gingival Recession Defects
Authors: Lamba Samiksha , Dahiya Ritu , Blaggana Anshu , Kaur Pawandeep , Gulia Krishan , Phogat Anjila , Sharma Jaya
Published: June 2022

Introduction Amnion membrane (AM) and platelet-rich fibrin (PRF) have been used as Guided Tissue Regeneration (GTR)-based root coverage procedures in treatment of gingival recession. The objective of the present study was to comparatively evaluate the coronally advanced flap (CAF) procedure in conjunction with AM versus CAF with PRF in patients with Miller's class I and II gingival recession defects (GRD).

Materials and Methods The sample size (Miller's Class I and Class II GRD) consisted of 24 patients who were stratified into two groups randomly (12 for each group). Group A patients were treated by CAF with PRF and Group B patients were treated by CAF with AM. Clinical parameters comprising plaque index (PI), gingival index (GI), pocket probing depth (PPD), clinical attachment level (CAL), and GRD were assessed at baseline, 3 months, and 6 months postoperatively.

Results The percentage of root coverage obtained in the study groups was 62% and 77%, respectively, for Groups A and B. Statistically significant difference was obtained in the clinical parameters (PPD, CAL, and GRD) of Group B, which was treated by CAF with AM.

Conclusion Significant difference was found between Group A (CAF+ PRF) and Group B (CAF+ AM) membrane treated sites in reduction of PPD, gain in clinical attachment level, reduction of GRD from baseline to 3 months and baseline to 6 months, with more significant results seen with Group B.
Intraoperative Imaging Improves Posterolateral THA Accuracy with Increased Time Cost
Authors: Ralston William M. , Aggarwal Ajay , Keeney James A.
Published: June 2022

Intraoperative imaging may improve total hip arthroplasty (THA) component placement, but the time and cost associated with this approach have not been well described. We assessed component placement accuracy, operative time, and operating room (OR) charges for 270 patients undergoing posterolateral THA (PL-THA) with or without intraoperative imaging. This study retrospectively compared 135 PL-THA performed with intraoperative digital radiography (group PLxr) and a contemporary cohort of 135 PL-THA performed without imaging (group PL). Postoperative radiographs were evaluated to determine outlier rates for acetabular inclination of 55 degrees or higher, anteversion less than 15 or more than 40 degrees, and leg length or offset differences more than 10 mm. Surgical procedure time was extracted from hospital OR records, and procedural costs were estimated from facility charges associated with 30-minute OR time blocks and intraoperative imaging. Group PLxr had significantly fewer outliers for acetabular inclination more than 50 degrees (5.2 vs. 21.5%, p < 0.001), acetabular inclination of 55 degrees or higher (0.7 vs. 8.1%, p = 0.01), acetabular anteversion less than 15 or more than 40 degrees (14.8 vs. 28.9%, p < 0.01), leg length difference more than 10 mm (2.2 vs. 10.4%, p = 0.01), and femoral offset difference more than 10 mm (1.5 vs. 9.6%, p < 0.01). The difference in component inclination less than 30 degrees was not significant (0.0 vs. 2.2%, p = 0.24). Intraoperative component adjustment occurred in 26 cases (21.5%), was associated with a 19-minute mean increase in operative time (p < 0.001) and $1,504 mean increase in facility charges compared with nonimaged cases. Imaged cases without component adjustment increased mean operative time by 9.4 minutes (p < 0.001) and mean operative charges by $766. Intraoperative imaging improves component placement accuracy during PL-THA and significantly reduces component placement outliers, particularly with respect to acetabular component inclination, femoral length, and femoral offset.

Level of Evidence Level III, case-control study.
Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report
Authors: Kumar Kishore S. , Naleer Mohamed H. , Visweswaran Vivek , Krishnamurthy Ganesh
Published: June 2022

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, pigmented tumor. It is a locally aggressive neoplasm of neural crest origin with a high recurrence rate. It occurs in craniofacial sites in more than 90% of cases and most commonly in the maxilla. It may also occur in epididymis, testis, ovaries, soft tissue, and bones of the extremities. It occurs in infants younger than 1 year of age with a slight male preponderance. We report a rare case of a child presenting with midline frontal pigmented MNTI.