bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolite Profiles of the Green Beans of Indonesian Arabica Coffee Varieties
Authors: Happyana Nizar , Pratiwi Amelinda , Hakim Euis Holisotan
Published: November 2021

The green beans of 3 Indonesian arabica coffee varieties, namely, ateng, buhun, and sigararutang, were analyzed with 1H NMR-based metabolomics coupled with alpha-glucosidase inhibitory activity assay. These coffees were cultivated in the same geographical conditions. The PLSDA model successfully classified the green coffee beans based on their varieties. To reveal the characteristic metabolites for each coffee variety, S-plot of two-class OPLSDA models was generated and analyzed. Ateng coffee was characterized with trigonelline, sucrose, 5-CQA, and acetic acid. The characteristic metabolites of buhun coffee were citric acid and malic acid. Meanwhile, the most discriminant compound of sigararutang coffee was quinic acid. HCA analysis revealed the lineage relationship of the 3 coffee varieties. Ateng coffee had closer lineage relationship to sigararutang compared to the buhun coffee. Alpha-glucosidase inhibitory activity of the coffee samples did not differ widely.

I

C

50

values of alpha-glucosidase inhibitory activity of ateng, sigararutang, and buhun coffees were

3.01
±
0.16

,

3.14
±
0.20

, and

5.05
±
0.28

 mg/mL, respectively. Although grown in the same geographical conditions, our results revealed that each coffee variety possessed a unique metabolome clarifying the diversity of Indonesian arabica coffees. This study verified that 1H NMR-based metabolomics is an excellence method for discovering the lineage relationship in the samples with different varieties or cultivars.
Possible Iodine-Induced Thyrotoxicosis in a Previously Healthy Adolescent following Administration of Iodinated Contrast Media
Authors: Apsan Jennifer , Antal Zoltan
Published: November 2021

Introduction. Jod-Basedow Syndrome refers to a paradoxical phenomenon in which large loads of iodine can cause hyperthyroidism. It is most commonly seen in populations already at risk for thyroid disease or those with underlying kidney disease. Case Presentation. We present a case of an acutely ill 17-year-old boy with symptomatic hyperthyroidism following an iodinated contrast CT scan to rule out appendicitis. Discussion/Conclusion. This case underscores the importance of recognizing this phenomenon even in the pediatric population and in those with no preexisting history of thyroid disease. Course complications including bronchospasm, hypertension, transaminitis, and bilateral palmar desquamating rash are rare and highlight the complexities involved in the disease state and in managing side effect profiles of treatment.
Software Defect Prediction Based on Elman Neural Network and Cuckoo Search Algorithm
Authors: Song Kun , Lv ShengKai , Hu Die , He Peng
Published: November 2021

In software engineering, defect prediction is significantly important and challenging. The main task is to predict the defect proneness of the modules. It helps developers find bugs effectively and prioritize their testing efforts. At present, a lot of valuable researches have been done on this topic. However, few studies take into account the impact of time factors on the prediction results. Therefore, in this paper, we propose an improved Elman neural network model to enhance the adaptability of the defect prediction model to the time-varying characteristics. Specifically, we optimized the initial weights and thresholds of the Elman neural network by incorporating adaptive step size in the Cuckoo Search (CS) algorithm. We evaluated the proposed model on 7 projects collected from public PROMISE repositories. The results suggest that the contribution of the improved CS algorithm to Elman neural network model is prominent, and the prediction performance of our method is better than that of 5 baselines in terms of F-measure and Cliff’s Delta values. The F-measure values are generally increased with a maximum growth rate of 49.5% for the POI project.
Channel Estimation for Broadband Millimeter Wave MIMO Systems Based on High‐Order PARALIND Model
Authors: Jiang Ting , Song Maozhong , Zhu Xiaorong , Liu Xu
Published: November 2021

Channel state information (CSI) is important to improve the performance of wireless transmission. However, the problems of high propagation path loss, multipath, and frequency selective fading make it difficult to obtain the CSI in broadband millimeter‐wave (mmWave) system. Based on the inherent multidimensional structure of mmWave multipath channels and the correlation between channel dimensions, mmWave multiple input multiple output (MIMO) channels are modelled as high‐order parallel profiles with linear dependence (PARALIND) model in this paper, and a new PARALIND‐based channel estimation algorithm is proposed for broadband mmWave system. Due to the structural property of PARALIND model, the proposed algorithm firstly separates the multipath channels of different scatterers by PARALIND decomposition and then estimates the channel parameters from the factor matrices decomposed from the model based on their structures. Meanwhile, the performance of mmWave channel estimation is analysed theoretically. A necessary condition for channel parameter estimation is given based on the uniqueness principle of PARALIND model. Simulation results show that the proposed algorithm performs better than traditional compressive sensing‐based channel estimation algorithms.
Exploitation of Sulfated Glycosaminoglycan Status for Precision Medicine of Triplatin in Triple-Negative Breast Cancer
Authors: Hampton James D. , Peterson Erica J. , Katner Samantha J. , Turner Tia H. , Alzubi Mohammad A. , Harrell J. Chuck , Dozmorov Mikhail G. , Turner Joseph B. McGee , Gigliotti Pam J. , Kraskauskiene Vita , Shende Mayuri , Idowu Michael O. , Puchalapalli Madhavi , Hu Bin , Litovchick Larisa , Katsuta Eriko , Takabe Kazuaki , Farrell Nicholas P. , Koblinski Jennifer E.
Published: November 2021

Triple-negative breast cancer (TNBC) is a subtype of breast cancer lacking targetable biomarkers. TNBC is known to be most aggressive and when metastatic is often drug-resistant and uncurable. Biomarkers predicting response to therapy improve treatment decisions and allow personalized approaches for patients with TNBC. This study explores sulfated glycosaminoglycan (sGAG) levels as a predictor of TNBC response to platinum therapy. sGAG levels were quantified in three distinct TNBC tumor models, including cell line–derived, patient-derived xenograft (PDX) tumors, and isogenic models deficient in sGAG biosynthesis. The in vivo antitumor efficacy of Triplatin, a sGAG-directed platinum agent, was compared in these models with the clinical platinum agent, carboplatin. We determined that >40% of TNBC PDX tissue microarray samples have high levels of sGAGs. The in vivo accumulation of Triplatin in tumors as well as antitumor efficacy of Triplatin positively correlated with sGAG levels on tumor cells, whereas carboplatin followed the opposite trend. In carboplatin-resistant tumor models expressing high levels of sGAGs, Triplatin decreased primary tumor growth, reduced lung metastases, and inhibited metastatic growth in lungs, liver, and ovaries. sGAG levels served as a predictor of Triplatin sensitivity in TNBC. Triplatin may be particularly beneficial in treating patients with chemotherapy-resistant tumors who have evidence of residual disease after standard neoadjuvant chemotherapy. More effective neoadjuvant and adjuvant treatment will likely improve clinical outcome of TNBC.
Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis
Authors: Takeuchi Sora , Kawakami Tamihiro , Okano Tatsuro , Shida Haruki , Nakazawa Daigo , Tomaru Utano , Ishizu Akihiro , Kadono Takafumi
Published: November 2021

Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellular traps (NETs) is involved in the pathogenesis of vasculitis, especially in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This study aimed to clarify whether NETs are implicated in IgA vasculitis. Methods: Twenty-two patients with IgA vasculitis and 4 healthy volunteers were enrolled in this study. Serum levels of myeloperoxidase (MPO)-DNA complex, a fragment derived from NETs, were determined by enzyme-linked immunosorbent assay (ELISA), and the association between MPO-DNA complex levels and clinical parameters was examined. The presence of the ANCA was also assessed by ELISA specific for MPO and proteinase 3 (PR3) and indirect immunofluorescence (IIF), followed by assessing the differences in clinical parameters with and without the ANCA. Results: Serum MPO-DNA complex levels were significantly higher in patients with IgA vasculitis than those in healthy controls. A significant positive correlation between the serum MPO-DNA complex and IgA levels was noted. Interestingly, 63.6% of IgA vasculitis patients were ANCA-positive in IIF with an atypical pattern, whereas neither MPO-ANCA nor PR3-ANCA was detected by ELISA. These findings indicated that some IgA vasculitis patients possessed the so called minor ANCA. Serum IgA and MPO-DNA complex levels and the frequency of hematuria in the minor ANCA-positive group were significantly higher than in the minor ANCA-negative group. Conclusion: The collective findings suggested that NETs are certainly involved in the pathogenesis of IgA vasculitis.
Mycobacteriophages to Treat Tuberculosis: Dream or Delusion?
Authors: Diacon Andreas H. , Guerrero-Bustamante Carlos A. , Rosenkranz Bernd , Rubio Pomar Francisco J. , Vanker Naadira , Hatfull Graham F.
Published: November 2021

Rates of antimicrobial resistance are increasing globally while the pipeline of new antibiotics is drying up, putting patients with disease caused by drug-resistant bacteria at increased risk of complications and death. The growing costs for diagnosis and management of drug resistance threaten tuberculosis control where the disease is endemic and resources limited. Bacteriophages are viruses that attack bacteria. Phage preparations served as anti-infective agents long before antibiotics were discovered. Though small in size, phages are the most abundant and diverse biological entity on earth. Phages have co-evolved with their hosts and possess all the tools needed to infect and kill bacteria, independent of drug resistance. Modern biotechnology has improved our understanding of the biology of phages and their possible uses. Phage preparations are available to treat meat, fruit, vegetables, and dairy products against parasites or to prevent contamination with human pathogens, such as Listeria monocytogenes, Escherichia coli, or Staphylococcus aureus. Such phage-treated products are considered fit for human consumption. A number of recent case reports describe in great detail the successful treatment of highly drug-resistant infections with individualized phage preparations. Formal clinical trials with standardized products are slowly emerging. With its highly conserved genome and relative paucity of natural phage defence mechanisms Mycobacterium tuberculosis appears to be a suitable target for phage treatment. A phage cocktail with diverse and strictly lytic phages that kill all lineages of M. tuberculosis, and can be propagated on Mycobacterium smegmatis, has been assembled and is available for the evaluation of optimal dosage and suitable routes of administration for tuberculosis in humans. Phage treatment can be expected to be safe and active on extracellular organisms, but phage penetration to intracellular and granulomatous environments as well as synergistic effects with antibiotics are important questions to address during further evaluation.
Minimally Invasive Precise Application of Bioadhesives to Prevent IPPROM on a Pregnant Sheep Model
Authors: Devaud Yannick R. , Stäuble Senta , Moehrlen Ueli , Weisskopf Miriam , Vonzun Ladina , Zimmermann Roland , Ehrbar Martin , Ochsenbein-Kölble Nicole
Published: November 2021

Introduction: Iatrogenic preterm premature rupture of the membrane remains the Achille’s heel of fetoscopy. The aim of this study was to show in vivo feasibility of fetal membrane (FM) defect sealing by the application of tissue glues with umbrella-shaped receptors. Methods: First, we adapted our previously described ex vivo strategy and evaluated the adhesion strength of different tissue glues, Histoacryl® and Glubran2®, by bonding polytetrafluoroethylene or silicone encapsulated nitinol glue receptor to human FM. Then, we exposed pregnant sheep uterus through a laparotomy and placed a 10-French trocar into the amniotic cavity through which the umbrella-shaped glue receptor (n = 9) was inserted and fixated onto the FM with the tissue glues (n = 8). The tightness of the sealed defects was assessed 4 h post-surgery. Results: Both tissue glues tested resulted in adhesion of the glue receptors to the FM ex vivo. In vivo, all glue receptors opened in the amniotic cavity (n = 9) and all successfully placed glue receptors sealed the FM defect (n = 8). Four hours post-surgery, 2 treatment sites showed minimal leakage whereas the negative control without glue (n = 1) showed substantial leakage. Discussion: This in vivo study confirms that fetoscopically induced FM defects can be sealed by the application of tissue adhesives.
A Predictive Model for Avoiding Follow-Up Paracentesis in Spontaneous Bacterial Peritonitis
Authors: Santos Ana Luísa , Coelho Rosa , Silva Marco , Morais Rui , Cardoso Hélder , Macedo Guilherme
Published: November 2021

Background: Recent studies suggest that follow-up paracentesis (FuP) in cases of spontaneous bacterial peritonitis (SBP) should only be performed if there is a clinical and/or analytic worsening. We aimed to evaluate which patients with SBP would benefit from the FuP. Métodos: This retrospective study included consecutive patients diagnosed with SBP between January 2011 and June 2018 in our tertiary center. Clinical and analytical data were obtained at baseline and on the third day of antibiotic therapy. An adequate response on the third day of treatment was defined by a decrease of ≥25% in the neutrophil count of the ascitic fluid (AF). Results: Ninety-six episodes of PBE in 75 patients (79% male sex, mean age 61 ± 11 years old) were included. At admission, a higher serum neutrophil count (p = 0.043), a lower level of serum total proteins (p = 0.040), a positive culture in AF (p < 0.001) and a previous diagnosis of diabetes mellitus (p = 0.035) were related to inadequate response (IR). At day 3, acute kidney injury (p = 0.023), C-reactive protein >100 mg/L (p < 0.001), the presence of fever (p = 0.047) and abdominal pain (p < 0.001) were also associated with IR. In multivariate analysis, the presence of respiratory insufficiency (OR = 16.403; 95% CI: 2.315–116.222; p = 0.005) and abdominal pain (OR = 10.381; 95% CI: 1.807–59.626; p = 0.009) at admission, serum white blood cell count >9 × 109 (OR = 5.832; 95% CI: 1.275–26.669; p = 0.023), and CRP >100 mg/L (OR = 5.043; 95% CI: 1.267–20.076; p = 0.022) at day 3 of antibiotic therapy were predictors of IR. The predictive model presented good accuracy [AUROC of 0.893 (p < 0.001)] – a cutoff of 0.090 had a sensitivity, specificity, positive predictive value, and negative predictive value for IR of 97, 46, 83, and 77%, respectively. Conclusions: The performance of FuP on day 3 after the beginning of empiric therapy should be individualized, according to clinical and analytic variables of this predictive model.
Endometriumkarzinom: Kombination aus Lenvatinib und Pembrolizumab zeigt Wirksamkeit unabhängig vom Mikrosatellitenstatus
Authors: Matz Sarah
Published: November 2021

Purpose: Patients with advanced endometrial carcinoma have limited treatment options. We report final primary efficacy analysis results for a patient cohort with advanced endometrial carcinoma receiving lenvatinib plus pembrolizumab in an ongoing phase Ib/II study of selected solid tumors. Methods: Patients took lenvatinib 20 mg once daily orally plus pembrolizumab 200 mg intravenously once every 3 weeks, in 3-week cycles. The primary end point was objective response rate (ORR) at 24 weeks (ORRWk24); secondary efficacy end points included duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Tumor assessments were evaluated by investigators per immune-related RECIST. Results: At data cutoff, 108 patients with previously treated endometrial carcinoma were enrolled, with a median follow-up of 18.7 months. The ORRWk24 was 38.0% (95% CI, 28.8% to 47.8%). Among subgroups, the ORRWk24 (95% CI) was 63.6% (30.8% to 89.1%) in patients with microsatellite instability (MSI)-high tumors (n = 11) and 36.2% (26.5% to 46.7%) in patients with microsatellite-stable tumors (n = 94). For previously treated patients, regardless of tumor MSI status, the median DOR was 21.2 months (95% CI, 7.6 months to not estimable), median PFS was 7.4 months (95% CI, 5.3 to 8.7 months), and median OS was 16.7 months (15.0 months to not estimable). Grade 3 or 4 treatment-related adverse events occurred in 83/124 (66.9%) patients. Conclusion: Lenvatinib plus pembrolizumab showed promising antitumor activity in patients with advanced endometrial carcinoma who have experienced disease progression after prior systemic therapy, regardless of tumor MSI status. The combination therapy had a manageable toxicity profile. Trial registration: ClinicalTrials.gov NCT02501096.
Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction
Authors: Malhotra Rajeev , Nicholson Christopher J. , Wang Dongyu , Bhambhani Vijeta , Paniagua Samantha , Slocum Charles , Sigurslid Haakon H. , Lino Cardenas Christian L. , Li Rebecca , Boerboom Sophie L. , Chen Yin-Ching , Hwang Shih-Jen , Yao Chen , Ichinose Fumito , Bloch Donald B. , Lindsay Mark E. , Lewis Gregory D. , Aragam Jayashri R. , Hoffmann Udo , Mitchell Gary F. , Hamburg Naomi M. , Vasan Ramachandran S. , Benjamin Emelia J. , Larson Martin G. , Zapol Warren M. , Cheng Susan , Roh Jason D. , O’Donnell Christopher J. , Nguyen Christopher , Levy Daniel , Ho Jennifer E.
Published: November 2021

Objective:

Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). MGP (matrix Gla protein) is implicated in vascular calcification in animal models, and circulating levels of the uncarboxylated, inactive form of MGP (ucMGP) are associated with cardiovascular disease-related and all-cause mortality in human studies. However, the role of MGP in arterial stiffness is uncertain.

Approach and Results:

We examined the association of ucMGP levels with vascular calcification, arterial stiffness including carotid-femoral pulse wave velocity (PWV), and incident heart failure in community-dwelling adults from the Framingham Heart Study. To further investigate the link between MGP and arterial stiffness, we compared aortic PWV in age- and sex-matched young (4-month-old) and aged (10-month-old) wild-type and Mgp
+/−
mice. Among 7066 adults, we observed significant associations between higher levels of ucMGP and measures of arterial stiffness, including higher PWV and pulse pressure. Longitudinal analyses demonstrated an association between higher ucMGP levels and future increases in systolic blood pressure and incident HFpEF. Aortic PWV was increased in older, but not young, female Mgp
+/−
mice compared with wild-type mice, and this augmentation in PWV was associated with increased aortic elastin fiber fragmentation and collagen accumulation.

Conclusions:

This translational study demonstrates an association between ucMGP levels and arterial stiffness and future HFpEF in a large observational study, findings that are substantiated by experimental studies showing that mice with Mgp heterozygosity develop arterial stiffness. Taken together, these complementary study designs suggest a potential role of therapeutically targeting MGP in HFpEF.
From Academic Anthropology to Esoteric Religion
Authors: Kostićová Zuzana Marie
Published: November 2021

Carlos Castaneda has been studied mostly as a fraud anthropologist, novelist/philosopher and a contributor to the emerging phenomenon of neo-shamanism. Instead, this article focuses on Castaneda’s individual philosophy and religious system as developed in his written works. A threefold classification is proposed—early, transitional, and late works, complete with chief characteristics of each. The analysis shows how Castaneda slowly drifted from the scholarly style through stress on the narrative to full-fledged religious texts. These changes also reflect on Castaneda’s personal life; from academic ambition through public scandal ‘debunking’ his counterfeit works to the formation of a little new religious movement, of which Castaneda was a charismatic leader. Unlike most scholarly analyses of Castaneda that focus mainly on the early writings, this article takes into serious consideration his late works and shows that it was here that the author fully developed as a religious thinker and guru.
Jihad as an Individual Duty (farḍ al-ʻayn) in the Ideology of Circassian Sultans (1382–1517)
Authors: Zelenev Evgeny I. , Iliushina Milana
Published: November 2021

This article is devoted to the study of the development of the theory and practice of jihad during the rule of the Circassian sultans in Egypt and Syria (1382–1517). The purpose of the study is to trace the development of key aspects of jihad, to identify features of its perception in the Mamluk state. An essential feature of the theory of jihad in the Mamluk period is the interpretation of jihad as farḍ al-ʿayn (the individual duty of every Muslim).

While studying the theory of jihad, the authors rely on a holistic and balanced approach justified in the papers of M. Bonner and D. Cook and their interpretation of the concept of jihad, which has a centuries-old history of development and a sophisticated, multi-layered set of meanings. Another methodological basis of the present paper was the concept of minimalism and maximalism, developed by Yusef Waghid.

The source base for the study of jihad theory is the works of Ibn al-Nahhas (d. 1411), a prominent philosopher of the Mamluk era. The interpretation of jihad as an individual duty of every Muslim, substantiated by Ibn al-Nahhas, was the foundation of the volunteer movement that developed in Egypt and Syria in the 15th century.

The doctrine of jihad where the concepts of justice (al-‘adl) and truth (al-ḥaqq) play a key role, was used by the Mamluks and then by the Ottomans as a powerful ideological tool to manipulate the minds of Muslims. The relevance of the study is that the findings are not only true for the Middle Ages but are directly related to the present.
Again on the Demoness Šaša
Authors: Arakelova Victoria
Published: November 2021

The paper discusses the genesis of the demoness Šaša, an antagonist of procreation of the human race, attested in folk beliefs of Iranian peoples.
Colloquium 1 Dialectic, Persuasion, and Science in Aristotle
Authors: Dow Jamie
Published: November 2021

What is dialectic and what is it for, in Aristotle? Aristotle’s answer in Topics 1.2 seems surprisingly lacking in unity. He seems to imply that insofar as dialectic is an expertise (τέχνη), it is a disposition to three (possibly four) different kinds of productive achievement. Insofar as dialectic is a method, it is one whose use is seemingly subject to multiple, differing standards of evaluation. The goal of the paper is to resist this problematic “multi-tool” view of Aristotelian dialectic, by explaining how dialectic’s contributions to training, encounters, and the philosophical sciences are of the same kind. What unifies them, I argue, is the kind of reasoning that improves the epistemic position of the person that engages with it. The kind of reasoning-based practices in which dialectic is the expertise are, at heart, tools of inquiry, tools for improving people’s understanding. This is why dialectic is beneficial for persuasive encounters: it is an expertise that enables its possessor to persuade by improving the understanding of their participants.
Colloquium 2 Commentary on Trott
Authors: Lockwood Thornton C.
Published: November 2021

In her “Saving the Appearances of Plato’s Cave,” Dr. Adriel M. Trott argues that “the philosopher’s claim to true knowledge always operates within the realm of the cave.” In order to probe her claim, I challenge her to make sense of “politics in the cave,” namely, the status and practices of two categories of people in the cave: “woke” cave-dwellers (namely, those who recognize shadows as shadows but have not left the cave) and “woke” puppeteers (namely, philosophers ruling within the cave).
Colloquium 3 Commentary on Elliott
Authors: Sim May
Published: November 2021

Jay Elliott considers Aristotle’s view on the voluntariness of virtue and vice in his Nicomachean Ethics III.5 by exploring two rival interpretations. According to Elliott, the libertarian reading emphasizes the freedom that mature agents have to change their characters after rational reflection but neglects the role that upbringing plays in character formation. In contrast, the compatibilist reading stresses the agents’ upbringing in shaping their beliefs and desires. Elliott explains that because compatibilists maintain that agents’ actions stem from their own beliefs and desires, their actions, which reveal their character, are voluntary. Nevertheless, Elliott holds that because the agents, for the compatibilists, lack the power to change their beliefs and desires, the compatibilist account downplays the voluntariness of character in Aristotle’s own view. Elliott criticizes these rival interpretations and focuses on the concept of “practice” to argue that Aristotle’s view of character is both voluntary and subject to one’s upbringing. I discuss Aristotle’s concepts of voluntariness and practice in evaluating Elliott’s interpretation.
Colloquium 5 Anger and Our Humanity: Transhumanists Stoke the Flames of an Ancient Conflict
Authors: Levin Susan B.
Published: November 2021

This paper presents Stoicism as, in broad historical terms, the point of origin in Western thought of an extreme form of rational essentialism that persists today in the debate over human bioenhancement. Advocates of “radical” enhancement (or transhumanists) would have us codify extreme rational essentialism through manipulation of genes and the brain to maximize rational ability and eliminate the capacity for emotions deemed unsalutary. They, like Stoics, see anger as especially dangerous. The ancient dispute between Stoics and Aristotle over the nature and permissibility of anger has contemporary analogues. I argue that, on the merits, this controversy should, finally, be put to rest in Aristotle’s favor. Beyond its philosophical assets, Aristotle’s perspective meshes well with “appraisal theory” of emotion in psychology and corresponding discoveries in neuroscience. What’s more, consideration of the ongoing struggle to achieve full racial equality in the United States supports the view that anger at this ongoing gap between λόγος and ἔργον is legitimate, and has a constructive role to play in furthering liberal democracy. As we are well positioned to retire the Stoics’ legacy regarding anger, all the more should we eschew transhumanists’ proposal to implement their position biologically, at which point debate over the nature and worth of anger would be permanently moot.
Taxonomic notes on the genus Furcaperla (Plecoptera: Perlidae) from China
Authors: YAN YANHUA , LI MENGYU , LI WEIHAI
Published: November 2021

Two species of the genus Furcaperla Sivec 1988 (in: Sivec et al. 1988), F. bifurcata (Wu, 1948) and F. jiangxiensis Yang & Yang, 1991 are illustrated and redescribed. The taxonomic relationship of F. bifurcata and F. jiangxiensis is discussed. An unassociated female from Guangxi Zhuang Autonomous Region, Furcaperla Cn-G is described under informal designation. The first record for F. jiangxiensis from Fujian Province is given.
Seeking Support in Teacher Education for Racial Knowledge: The Role of Professional Networks and Social Identities
Authors: Enumah Lisette
Published: November 2021

Drawing from the narrated experiences of teacher educators (TEs) at different institutions, this paper analyzes TEs’ perceptions of support related to their work in teaching about race and racism. TEs varied in the extent to which they viewed their institution as supportive, and they identified factors that signaled that their institution supported teacher learning about race and racism. TEs also described how their racial identities and positional privilege related to tenure status informed engagement with peers both for providing and seeking support. Implications for teacher education programs in providing support for TEs who teach about race and racism are discussed.
‘Foreigners in Our Schools’: Cultural Diversity, Othering, and the Desire for Justice in Schools
Authors: Szelei Nikolett , Pinho Ana Sofia , Tinoca Luís
Published: November 2021

This study explored ‘cultural diversity’ in urban schools in Portugal by conducting discourse analysis on interviews with school practitioners. Findings show that ‘cultural diversity’ was dominantly anchored in Othering ‘foreigners’ that mainly associated ‘non-native speakers’ to difficulties in integration, participation and teachers’pedagogical work. However, contradicting discourses somewhat resisted Othering by highlighting meaningful differences, all students’ rights, and calling for pedagogical changes. By showing the ambivalences in how students, teachers and pedagogical relationships are viewed, we both alert for an exclusionary conceptualization of ‘cultural diversity’, and question Othering as a fundamentalizing discourse to fully govern ‘cultural diversity’ in schools.
A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
Authors: Hong Min , Lu Min , Qian Yimin , Wei Liping , Zhang Yaqun , Pan Xueying , Li Hua , Chen Huaying , Tang Naping
Published: November 2021

Mulberry extract from Fructus Mori contains an anthocyanin pigment and has been widely used as a food additive in China and other Eastern Asian countries. Only few research has been done on toxicological profiling of mulberry extract for its safety evaluation; however, the data is inconclusive. In the current study, mulberry extract of 4200, 1400, or 466 mg/kg were orally administrated to Sprague Dawley rats for 90 consecutive days followed by a recovery period of 28 days. No abnormalities were detected in body weights, food intake, ophthalmological, hematological, coagulation, clinical chemistry, and organ weights parameters. Discoloration of urine (red, purple, and brown) and feces (black), along with bedding material (purple) were observed in the 4200 mg/kg group. Further, microscopic examination revealed brown granules in the renal tubular cells for rats in 4200 and 1400 mg/kg groups. Since these changes were associated with excretory effect of the extract, the No Observed Adverse Effect Level was determined to be 4200 mg/kg, which was equivalent to the 1058.5 mg/kg of anthocyanin.
The Racializing Womb: Surrogacy and Epigenetic Kinship
Authors: Keaney Jaya
Published: November 2021

In gestational surrogacy arrangements, the womb is often figured as a holding environment that brings the child of commissioning parents to fruition but does not shape fetal identity. This article probes the racial imaginary of such a figuration—what I term the “nonracializing womb”—where gestation is seen as peripheral to racial transmission. Drawing on feminist science studies frameworks and data from interviews with parents who commissioned surrogates, this article traces the cultural politics of the nonracializing womb, positioning it as an index for broader understandings of race, reproductive labor, and kinship that hinge on nuclear and biogenetic forms. It then problematizes this figure of gestation by engaging emerging research on environmental epigenetics, which offers a lively model of pregnancy as shaping fetal biology, blurring the lines between surrogate and fetus. I argue that epigenetics offers a resource to reimagine gestation as a racializing process, by theorizing race not as solely genetic, but as relational, socio-environmental, and forged through distributed kinship lineages.
Rotation-hinged knee prosthesis for the treatment of Charcot arthropathy: a case report and literature review
Authors: Du Weibin , Dai Rongdan , Chen Rongliang , Shen Fuxiang
Published: November 2021

Charcot arthropathy is a type of destructive osteoarthropathy characterized by neurotrophic and sensory disorders. The condition is relatively rare, with an insidious onset, and it is easily misdiagnosed. Total knee arthroplasty (TKA) can cause excessive joint wear, continuous inflammatory stimulation of the prosthesis, postoperative residual cavity, prosthesis loosening and subsidence, peripheral fracture, infection, and other complications. Furthermore, these complications are more likely to occur in patients with Charcot arthropathy because of disease-specific pathological characteristics, when TKA is performed. Therefore, Charcot arthropathy was once a contraindication to TKA. Recently, with the optimization of joint prostheses and the maturity of surgical techniques, more studies have reported successful cases of TKA in patients with Charcot arthropathy. We report a case of Charcot arthropathy in our hospital, and describe the patient’s medical history, clinical symptoms, signs, imaging findings, diagnosis, and the entire TKA process, to explore the TKA strategy and prosthesis selection in a patient with Charcot arthropathy.
Using a Social Determinants of Health Summary Measure to Predict General Health Status in the BRFSS
Authors: Nelson Candace C.
Published: November 2021

Purpose

This study aims to assess the relationship between social determinants of health (SDoH) burden and overall health.

Design

Three years of Behavioral Risk Factor Surveillance System (BRFSS) data (2017–2019) were combined for this cross-sectional study.

Setting

Massachusetts.

Subjects

Out of a possible 21,312 respondents, 16,929 (79%) were eligible for inclusion.

Measures

To create the SDoH summary measure, items assessing social risk experiences including financial instability (1 item), housing instability (2 items), perceptions of neighborhood crime (1 item), and food insecurity (2 items) were summed to create a count of risk experiences. Outcome measures included self-rated general health, days of poor physical health, and days of poor mental health.

Analysis

Multivariable logistic regression was used to evaluate the association between each outcome and the SDoH summary measure, adjusting for demographic confounders.

Results

In adjusted analyses, respondents who reported experiencing 1, 2, 3, or 4+ SDoH had a 1.6 (95% CI: 1.3–2.0), 2.9 (95% CI: 2.3–3.7), 3.2 (95% CI: 2.4–4.3), or 5.3 (95% CI: 4.0–7.0) increased odds (respectively) of self-rated fair/poor health, compared to those who reported zero SDoH. The adjusted relationship between the SDoH summary measure and physical health and mental health was similar in magnitude and statistically significant.

Conclusions

These results demonstrate that the overall burden of risk due to SDoH is an important predictor of health.
Do Smart Cities Technologies Contribute to Local Economic Development?
Authors: Abutabenjeh Sawsan , Nukpezah Julius A. , Azhar Annus
Published: November 2021

Governments around the world are exploring strategies that contribute to increased government performance and economic development that enable them to meet the service-tax expectations of their citizens. Within the framework of technology use in public management, this sudy examines the effects of smart cities technologies on the importance that chief administrative officers attach to local economic development. Drawing on the Digital Era Governance (DEG) model for theoretical context, this study uses logistic regressions derived from the 2016 International City/County Management Association survey on smart cities and the U.S. Census Bureau. The results show that the level of commitment to, the extent of engagement with, and the barriers faced in implementing smart cities technologies are associated with the importance of local economic development. Among other variables, poverty and education were also found to be significant predictors of the importance of local economic development.
The Mechanisms of Implementation Support - Findings from a Systematic Integrative Review
Authors: Albers Bianca , Metz Allison , Burke Katie , Bührmann Leah , Bartley Leah , Driessen Pia , Varsi Cecilie
Published: November 2021

Purpose: Mechanisms of Change (MoC) explain how strategies used to enhance the uptake of evidence in social and human services enable change in the behaviors of individual practitioners, organizational leaders or entire organizations, and systems. One such strategy is the use of implementation support practitioner (ISPs). This study examines the mechanisms through which ISPs facilitate behavior supportive of the implementation of research-supported interventions. Methods: A systematic, integrative review was conducted. The conceptualization of MoCs built on a model by Dalkin and colleagues. Results: Based on a unique combination of knowledge, skills, and attitudes, ISPs install trust in and among their stakeholders and utilize this trust to promote meaningful and relevant learning; provide ongoing opportunities for learning, reflection, and support; help to span boundaries; and positively motivate stakeholders. Discussion: ISPs do not represent a short cut to better implementation. They represent an additional implementation challenge that requires dedicated attention and resources.
A Case of Nonsyndromic Craniosynostosis in an Infant Child of Jehovah's Witness Parents: Is Surgical Correction Appropriate?
Authors: Linkugel Andrew D. , Yu Jennifer , Kopar Piroska K. , Kodner Ira J. , Brown Douglas , Patel Kamlesh B.
Published: November 2021

An infant with nonsyndromic craniosynostosis is brought to clinic by his Jehovah's Witness parents to discuss treatment. Five potential courses of action are discussed in the context of biomedical ethics principles. The potential conflict between parents’ autonomy to make decisions for their child and the surgeon's ethical duty of beneficence to the patient is explored.
Sensitivity and specificity of Sirius indices in diagnosis of keratoconus and suspect keratoconus
Authors: Salman Abdelrahman , Darwish Taym , Ali Ali , Ghabra Marwan , Rafea Shaaban
Published: November 2021

Aim

To estimate the sensitivity and specificity of topographic and tomographic corneal parameters as determined by Sirius (CSO, Florence, Italy) in discriminating keratoconus (KC) and suspect keratoconus from normal cornea.

Method

In this retrospective case-series study, keratoconus screening indices were measured using Sirius tomographer. Receiver operating characteristics (ROC) curves were used to determine the test's overall predictive accuracy (area under the curve) and to identify optimal cut-off points to maximize sensitivity and specificity in differentiating keratoconus and suspect keratoconus from normal corneas.

Results

Receiver operating characteristics (ROC) curve analyses showed high predictive accuracy for Symmetry Index back (SIb), Keratoconus Vertex front (KVf), Symmetry Index front (SIf), Keratoconus Vertex back (KVb), Apex Keratometry (Curve-Apex) and Minimum corneal Thickness (ThkMin) to distinguish keratoconus from normal (area under the curve > 0.9, all). Symmetry Index back was identified as the best diagnostic parameter for detecting suspect keratoconus with AUC of 0.86. Highest specificity to detect keratoconus and suspect keratoconus was seen for SIb, 99.87% and 84.66%, respectively. These values were associated with optimal cut-off points of 0.46 D for keratoconus and 0.12 D for suspect keratoconus.

Conclusion

Sirius parameters evaluated in the study were effective to differentiate keratoconus from normal corneas. However, Symmetry Index back was the index with the highest ability to detect suspect keratoconus.
Effect of Wastewater Discharge From Coffee Processing Plant on River Water Quality, Sidama Region, South Ethiopia
Authors: Genanaw Wubalem , Kanno Girum Gebremeskel , Derese Dawit , Aregu Mekonnen Birhanie
Published: November 2021

In Ethiopia, most of the coffee processing plants are generating large amounts of wastewater with high pollutant concentrations and discharge directly into the water bodies untreated or partially treated. The main objective of this study was to assess the effects of coffee wastewater discharged to river water quality using physicochemical parameters and macro-invertebrate indices. This study was conducted from November to the end of December 2019. Ten wastewater and river water samples were taken from coffee the processing plant and river. The macro-invertebrate samples were collected by kick sampling technique using a standard hand net. Shannon and Simpson diversity indices were examined at 3 sampling stations. The Pielou evenness index was also determined. It was found that except for TDS all the parameters of the raw wastewater and river water did not comply with the international discharge limit. The mean concentration of Faro coffee processing plant wastewater were BOD5 (2409.6 ± 173.1 mg/L), COD (4302 ± 437 mg/L), TSS (2824.6 ± 428.4 mg/L), TDS (3226 ± 623.6 mg/L), and TS (4183.3 ± 432.9 mg/L). Whereas from Bokaso coffee processing plant were BOD5 (3770 ± 604.4 mg/L), COD (4082.6 ± 921.9 mg/L), TSS (2766 ± 501.7 mg/L), TDS (3017 ± 747.6 mg/L), and TS (3874 ± 471.1 mg/L). A total of 392 macroinvertebrates belonging to 24 families and 7 orders were collected. The benthos assemblage communities in this river were 40, 56, and 296 at downstream 1, downstream 2, and upstream respectively. The value of the Simpson diversity index varies from 0.4 to 0.75. In the same manner, the value of the Shannon diversity index also varied from 0.5 to 1.36. Most of the physicochemical parameters of the raw wastewater were beyond the national and international discharge limits. The quality of Orsha river water downstream was more adversely affected compared to upstream.
Petrus van Musschenbroek (1692–1761), man of tribology
Authors: van Leeuwen Harry
Published: November 2021

Petrus van Musschenbroek was a famous scientist and inventor, natural philosopher, experimental physicist, engineer, instrument builder, experimenter, in the continental Newtonian tradition of Boerhaave and ‘s Gravesande. And: a tribologist. He is one who deserves more fame than he has received so far, and which is well documented in this publication. Van Musschenbroek coined the name tribometer for his device to measure friction in a journal bearing, and some authors rightly refer to this. However, what seems to have remained unnoticed until now is that he also published quantitative results of his friction measurements and tried to arrive at general laws of friction based on them. He reported in detail on friction experiments on sliding, dry as well as lubricated, sliders and journal bearings, a novum in his time, as early as in 1734. When the data from Van Musschenbroek's tables are mapped into graphs, a method which was not in use at that time, two Stribeck curves for journal bearings emerge. Van Musschenbroek's work deserves much more acclaim in the tribology community than it has now.
Practical Remote Workflow Solutions for Complex Digital Projects: Opportunities in a Pandemic
Authors: Pryse J.A.
Published: November 2021

The spread of COVID-19 has created numerous challenges in the field of archive management. Limited in-house office space, furloughs of personnel, and inconsistency, has highlighted the potential for the Carl Albert Congressional Research and Studies Center Archives (Center) to develop and implement improved accessibility measures to thousands of linear feet of material. Addition ally, the Center has found unique opportunities to collaborate with multiple academic institutions to propose large-scale digitization program exhibitions using the Center’s remote workflow model. One of the largest, most complex collections the Center has worked with during this time is the Political Commercial Collection (the Collection), which holds 119,000 film, audio, and videotape recordings of commercials aired between 1936 and present. It is the largest collection of political commercials in the world. The Center has developed a working pilot digitization project that has currently resulted in access to 16,000 digital videos for public researchers and over 10,000 available for on-line streaming during the pilot phase between April 16, 2020, and December 1, 2020. This paper presents the practical application of the Center’s simplified “Linear Reciprocity Workflow Model” to provide a systematic solution for digital and long-term preservation of complex collections. The Center has proven that limited personnel and reduced resources need not interrupt continued access to archival repositories.
Unstandard Deviation: The Untapped Value of Positive Deviance for Reducing Inequalities
Authors: Ruggeri Kai , Folke Tomas
Published: November 2021

Behavioral science is increasingly used in public policy to understand and address various manifestations of inequalities. Yet evidence from effective population-level interventions is limited. One framework, known as positive deviance, emphasizes individuals from disadvantaged circumstances who have significantly better outcomes than are typical for their group. Studying their behaviors and outcomes helps to understand what might explain their overall success. These insights could also be used to help others from these circumstances experience positive outcomes. Because positive deviance has been markedly understudied, we present a framework for doing so specifically within behavioral science for public policies aimed at reducing inequalities. Using examples from real-world and experimental insights on choices and outcomes of positive deviants, we encourage further study of their choices and trajectories over time to produce valuable insights. We propose that leveraging those findings would inform public policy by introducing interventions that are more ecologically sound and population-relevant and thus have a better chance at benefiting those who start off under adverse circumstances.
Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study
Authors: Al-Obaidly Sawsan , Salama Husam , Olukade Tawa , AlQubaisi Mai , Bayo Arabo , Al Rifai Hilal
Published: November 2021

Background

Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls.

Methods

We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death.

Results

The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017.

Conclusion

Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes.