bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Literature Review and Meta-Analysis
Authors: Luchinin Aleksander Sergeevich
Published: April 2022

Background. Up to now, R-CHOP-21 therapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) has been a standard option in the treatment of newly diagnosed diffuse large В-cell lymphoma (DLBCL). About 40-50 % of patients, however, show refractoriness to this therapy or develop early relapses. Materials & Methods. A systematic review and meta-analysis were aimed at comparing the efficacy and safety of different first-line regimens in DLBCL treatment on the basis of data derived from the clinical studies published in 20142021. Results. The outcomes of 22 clinical trials enrolling 9879 DLBCL patients were analyzed. The efficacies of different R-CHOP-21 therapy regimens were compared, and the pro-gression-free-survivals were estimated. The network meta-analysis showed that, in the total cohort, the most effective first-line regimens were VenR-CHOP (hazard ratio [HR] 0.61; 95% confidence interval [95% CI] 0.37-1.00) and Pola-R-CHP (HR = 0.73; 95% CI 0.47-1.12). For non-GCB (ABC) subtype patients less than 60 years of age, R-ACVBP (HR = 0.31; 95% CI 0.12-0.79) and IR-CHOP (HR = 0.56; 95% CI 0.36-0.86) regimens appeared to be more effective than R-CHOP-21. Conclusion. Today, the newly diagnosed DLBCL can be treated not only with R-CHOP-21, but also with alternative and more effective regimens. Their assignment, however, needs to be strictly personalized. IR-CHOP and R-ACVBP therapies can be administered in patients with non-GCB (ABC) subtype of DLBCL, if they are under 60 years of age. The list of these regimens can be further extended to include novel drugs, such as polatuzumab vedotin (its efficacy was confirmed by a randomized clinical trial) and venetoclax (its efficacy was confirmed by a non-randomized clinical trial).
Evaluation of Heterozygosity Loss in STR-Loci of Tumor DNA in Multiple Myeloma Patients with Plasmacytoma Based on the Molecular Analysis of Complex Archival Tumor Samples
Authors: Nikulina Elena Evgen'evna , Firsova M.V. , Risinskaya N.V. , Kozhevnikova Ya.A. , Solov'ev M.V. , Abramova T.V. , Obukhova T.N. , Kovrigina A.M. , Sudarikov A.B. , Mendeleeva L.P.
Published: April 2022

Background. Multiple myeloma (MM) is a hematological malignancy with plasma cells as substrate. Sometimes MM is characterized by plasmacytomas, i.e., intra- and extraosse-ous tumors. A paraffin block containing plasmacytoma substrate provides valuable material to be used for analyzing the molecular biological characteristics of tumor. STR-profil-ing is a method for simultaneous evaluation of DNA degradation and integral assessment of tumor genome stability. Aim. To describe STR-profiles of plasmacytoma DNA isolated from archival samples and to assess the integral stability of tumor genome against control DNA of patients. Materials & Methods. The retrospective study enrolled 10 MM patients with plasmacytoma (7 women and 3 men) aged 34-62 years (median 53.5 years) who were treated at the National Research Center for Hematology from 2013 to 2021. Paired tumor/control DNA samples were obtained from all 10 patients. Results. The present paper takes the first step in attempting a large-scale molecular genetic study of MM and provides first findings on the loss of heterozygosity (LOH) in plasmacytoma genome. All 10 patients showed LOH variants with different allelic loads having either deletion/ quantitatively neutral LOH or duplication of one of the two alleles and involving 1-8 STR-loci. In plasmacytoma substrate the number of loci with LOH tended to be higher in the group with MM relapses compared with plasmacytomas identified at disease onset. According to the data analysis, LOH was frequently (in 4 out of 10 cases) detected on chromosomes 1 (1q42), 6 (6q14), 7 (7q21.11), 13 (13q31.1), and 21 (21q21.1). Conclusion. The present paper shows the effectiveness of molecular analysis of DNAs being isolated from complex archival material consisting of paraffin blocks with plasmacytomas.
Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndromes with Trisomy 8 and/or Monosomy 7
Authors: Latypova M.V. , Mamaev Nikolai Nikolaevich , Gindina T.L. , Shakirova A.I. , Paina O.V. , Osipova A.A. , Rudakova T.V. , Morozova E.V. , Bondarenko S.N. , Zubarovskaya L.S.
Published: April 2022

The study assessed the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 34 patients with cytogenetically verified variants of myelodysplastic syndrome (MDS) with trisomy 8 and/or monosomy 7, who were treated at the RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation from 2013 to 2020. Both adult and pediatric MDS were analyzed without excluding the variants with two additional chromosomal abnormalities or complex karyotype. The study revealed that а) allo-HSCT should be performed in the treatment of both MDS variants; b) the outcomes of trisomy 8 treatment appeared to be better; c) children with monosomy 7 showed a higher rate of toxic complications in allo-HSCT.
Minimal $(D,D)$ conformal matter and generalizations of the van Diejen model
Authors: Nazzal Belal , Nedelin Anton , Razamat Shlomo
Published: April 2022

We consider supersymmetric surface defects in compactifications of
the 6d6d
minimal (D_{N+3},D_{N+3})(DN+3,DN+3)
conformal matter theories on a punctured Riemann surface. For the case
of N=1N=1
such defects are introduced into the supersymmetric index computations
by an action of the BC_1\,(\sim A_1\sim C_1)BC1(∼A1∼C1)
van Diejen model. We (re)derive this fact using three different field
theoretic descriptions of the four dimensional models. The three field
theoretic descriptions are naturally associated with algebras
A_{N=1}AN=1,
C_{N=1}CN=1,
and (A_1)^{N=1}(A1)N=1.
The indices of these 4d4d
theories give rise to three different Kernel functions for the
BC_1BC1
van Diejen model. We then consider the generalizations with
N>1N>1.
The operators introducing defects into the index computations are
certain A_{N}AN,
C_NCN,
and (A_1)^{N}(A1)N
generalizations of the van Diejen model. The three different
generalizations are directly related to three different effective gauge
theory descriptions one can obtain by compactifying the minimal
(D_{N+3},D_{N+3})(DN+3,DN+3)
conformal matter theories on a circle to five dimensions. We explicitly
compute the operators for the A_NAN
case, and derive various properties these operators have to satisfy as a
consequence of 4d4d
dualities following from the geometric setup. In some cases we are able
to verify these properties which in turn serve as checks of said
dualities. As a by-product of our constructions we also discuss a simple
Lagrangian description of a theory corresponding to compactification on
a sphere with three maximal punctures of the minimal
(D_5,D_5)(D5,D5)
conformal matter and as consequence give explicit Lagrangian
constructions of compactifications of this 6d SCFT on arbitrary Riemann
surfaces.
Azathioprine and Acenocoumarol Drug Interaction in Patients with
Crohn’s Disease: A Case Report
Authors: Ben-Hammamia Syrine , Charfi Ons , Belhadj Anis , Bouchrika Amal , Chebbi Faouzi , Lakhoua Ghozlane , El Aidli Sihem
Published: April 2022

Background:

Acenocoumarol is an anticoagulant with numerous drug reactions. We report
here, an unusual interaction between acenocoumarol and azathioprine.

Case Presentation:

A 35-year-old woman, treated with acenocoumarol for thrombosis of the superior
mesenteric vein, was prescribed azathioprine for Crohn’s disease. Three days later, INR values
decreased from 2.36 to 1.48. The dose of acenocoumarol had to almost be doubled to reach an INR
value of 2.56.
The interaction between azathioprine and acenocoumarol was then suspected. Few similar cases of
interactions between azathioprine and another coumarin derivative, warfarin, have been reported.
To our knowledge, this is the second case of such interaction reported with acenocoumarol in literature.

Conclusion:

Thus, despite the rarity of this interaction reporting, we draw attention to the importance
of close monitoring of INR values in patients treated with acenocoumarol associated with
azathioprine.
A Case of Odontogenic Myxoma of the Mandible with Expansion to the Alveolar Crest – Comparison of Imaging Findings and Pathological Findings: A Case Report
Authors: Yoshida Saori , Takeshita Yohei , Kawazu Toshiyuki , Matsumura Tatsushi , Asaumi Junichi , Nagatsuka Hitoshi , Yanagi Yoshinobu
Published: April 2022

Background:

An odontogenic myxoma is an intraosseous tumor characterized by stellate and spindle-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. We herein describe an odontogenic myxoma that expanded not only to the bone marrow but also to the outside of the alveolar bone. Diagnosis of an odontogenic myxoma in a tooth-deficient region by imaging findings alone was difficult because the positional relationship between the tumor and the tooth is unknown. Furthermore, some of these odontogenic myxomas reportedly show rapid growth.

Case Report:

Here, we present the case of a patient, a 44-year-old man, who had a hard, bone-like swelling on his right mandible molar region and mild paresthesia on his right cheek. An odontogenic myxoma and ameloblastoma were suspected based on the imaging findings; however, pathological examination of the biopsy led to a diagnosis of odontogenic myxoma. Right segmental mandibulectomy was performed, and there was no recurrence observed after surgery.

Conclusion:

To improve the accuracy of imaging diagnosis, it is important to compare the imaging findings with the pathological findings of the surgical specimen. This comparison in the present case revealed differences in the magnetic resonance imaging signal intensity in regions with different types of cell components.
Fabrication of Metal Sulfides/Graphene Nanocomposites for the
Applications in Supercapacitors. II: Ni-Mn-S/Mn-Cu-O/Graphene
Authors: Chen Yueqiu , Annamalai Kundrakudi P. , Chen Tianlu , Chen Xuyi , Tao Yousheng
Published: April 2022

Background:

Excessive use of fossil energy has exacerbated global warming,
and the goal of carbon neutralization has been put on the agenda. In order to make full
use of renewable energy and reduce greenhouse gas emissions, it is urgent to develop
environment-friendly energy storage devices. We previously reported metal sulfides/
graphene nanocomposites for the applications in supercapacitors (I. NiS/graphene).
Recent work was presented as the paper in the series (II. Ni-Mn-S/Mn-Cu-O/graphene).

Objective:

To synthesize graphene-supported multi-metal sulfides for electrochemical
capacitance storage.

Method:

The materials were prepared with a two-step hydrothermal method. Samples
were characterized by field emission scanning electron microscopy, X-ray powder diffraction,
and electrochemical measurements.

Results:

The as-fabricated electrode exhibited a specific capacitance of 566 F g–1 at the
current density of 1 A g–1 and a rate of 68% at 10 A g–1. The materials retained 75.8% of
the initial capacitance after 1000 charge-discharge cycles at 5 A g–1. The results suggest
optimum Ni-Mn-S/Mn-Cu-O/graphene composites for supercapacitor applications.

Conclusion:

The Ni-Mn-S/Mn-Cu-O/graphene composites with nanosheet structures
were prepared with a two-step hydrothermal method. The materials showed enhanced
electrochemical capacitance performances superior to the individual components.
How to save the world when we can’t
Authors: Kim Hanmin
Published: April 2022

This intervention explores our contemporary tendencies in the face of the ecological crisis through various artistic/activist projects. Interweaving different activities, such as an attempt to save an endangered marine species, an anti-deforestation campaign with an indigenous community in the Brazilian Amazon and practices to expand our moral boundary to non-human animals, it invites us to reflect on the choices and commitments we could make to invent a new sense of “we” and create spaces of hope and resistance.
The impact of overhead dumbbell squat towards swimming speed of Tirta Palm Swimming Club members
Authors: Putri Winaspita Aulia , Handoko Adelia , Elfiah Ulfa
Published: April 2022

Swimming athletes compete by how fast they can swim at a certain distance. One of the most important things that affect the swimming speed was the muscle strength of the arms and legs. The swimming speed can be increased by doing the physical exercise that can affect the arms and legs muscles which was called overhead dumbbell squat (ODS) exercise. The purpose of this study was to find out if there was an effect of ODS on increased breaststroke swimming speed of Tirta Palm Swimming Club members. This study was an experimental study with one group pretest-posttest design that was implemented for a month about 16-20 years old that met the qualifications of inclusion and did the ODS exercise thrice a week for 4 weeks. The duration of each exercise was 10 repetitions, 6 sets, and breaks for a minute in each set. The result showed that the average pretest swimming speed was 67,84 seconds and the post-test was 59,07 seconds. The analysis result of paired sample t-test showed a value p0,001, so there was a significant difference between pretest and posttest. It could be concluded that overhead dumbbell squat exercises could enhance the swimming speed of Tirta Palm Swimming Club members.
eHealth Interventions Targeting Poor Diet, Alcohol Use, Tobacco Smoking, and Vaping Among Disadvantaged Youth: Protocol for a Systematic Review
Authors: Egan Lyra , Gardner Lauren Anne , Newton Nicola , Champion Katrina
Published: April 2022

Background

Chronic disease burden is higher among disadvantaged populations. Preventing lifestyle risk behaviors such as poor diet, alcohol use, tobacco smoking, and vaping in adolescence is critical for reducing the risk of chronic disease and related harms in adolescence and adulthood. Although eHealth interventions are a promising prevention approach among the general population, it is unclear whether they adequately serve adolescents from disadvantaged backgrounds such as those living in geographically remote or lower socioeconomic areas.

Objective

This is the first systematic review to identify, evaluate, and synthesize evidence for the effectiveness of eHealth interventions targeting adolescents living in geographically remote or lower socioeconomic areas in preventing poor diet, alcohol use, tobacco smoking, and vaping.

Methods

A systematic search will be conducted in 7 electronic databases: the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, PROSPERO, MEDLINE (Ovid), Embase (Ovid), Scopus, and PsycInfo (Ovid). The search will be limited to eHealth-based experimental studies (ie, randomized controlled trials and quasi-experimental studies) targeting diet, alcohol use, tobacco smoking, and vaping among adolescents (aged 10-19 years). Eligible studies will be those reporting on at least one marker of socioeconomic status (eg, social class, household income, parental occupation status, parental education, and family affluence) or geographical remoteness (eg, living in rural, regional, and remote areas, or living outside major metropolitan centers). One reviewer will screen all studies for eligibility, of which 25% will be double-screened. Data will be extracted and summarized in a narrative synthesis. Risk of bias will be assessed using the Cochrane Revised Risk of Bias Tool.

Results

As of December 2021, the title and abstract screening of 3216 articles was completed, and the full-text review was underway. The systematic review is expected to be completed in 2022.

Conclusions

This systematic review will provide an in-depth understanding of effective eHealth interventions targeting poor diet, alcohol use, tobacco smoking, and vaping among adolescents living in geographically remote or lower socioeconomic areas and the factors that contribute to their effectiveness. This in turn will provide critical knowledge to improve future interventions delivered to these populations.

Trial Registration

PROSPERO CRD42021294119; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=294119

International Registered Report Identifier (IRRID)

PRR1-10.2196/35408
Integration of an Intensive Care Unit Visualization Dashboard (i-Dashboard) as a Platform to Facilitate Multidisciplinary Rounds: Cluster-Randomized Controlled Trial
Authors: Lai Chao-Han , Li Kai-Wen , Hu Fang-Wen , Su Pei-Fang , Hsu I-Lin , Huang Min‑Hsin , Huang Yen‑Ta , Liu Ping-Yen , Shen Meng-Ru
Published: April 2022

Background

 Multidisciplinary rounds (MDRs) are scheduled, patient-focused communication mechanisms among multidisciplinary providers in the intensive care unit (ICU).

Objective

i-Dashboard is a custom-developed visualization dashboard that supports (1) key information retrieval and reorganization, (2) time-series data, and (3) display on large touch screens during MDRs. This study aimed to evaluate the performance, including the efficiency of prerounding data gathering, communication accuracy, and information exchange, and clinical satisfaction of integrating i-Dashboard as a platform to facilitate MDRs.

Methods

A cluster-randomized controlled trial was performed in 2 surgical ICUs at a university hospital. Study participants included all multidisciplinary care team members. The performance and clinical satisfaction of i-Dashboard during MDRs were compared with those of the established electronic medical record (EMR) through direct observation and questionnaire surveys.

Results

Between April 26 and July 18, 2021, a total of 78 and 91 MDRs were performed with the established EMR and i-Dashboard, respectively. For prerounding data gathering, the median time was 10.4 (IQR 9.1-11.8) and 4.6 (IQR 3.5-5.8) minutes using the established EMR and i-Dashboard (P<.001), respectively. During MDRs, data misrepresentations were significantly less frequent with i-Dashboard (median 0, IQR 0-0) than with the established EMR (4, IQR 3-5; P<.001). Further, effective recommendations were significantly more frequent with i-Dashboard than with the established EMR (P<.001). The questionnaire results revealed that participants favored using i-Dashboard in association with the enhancement of care plan development and team participation during MDRs.

Conclusions

 i-Dashboard increases efficiency in data gathering. Displaying i-Dashboard on large touch screens in MDRs may enhance communication accuracy, information exchange, and clinical satisfaction. The design concepts of i-Dashboard may help develop visualization dashboards that are more applicable for ICU MDRs.

Trial Registration

ClinicalTrials.gov NCT04845698; https://clinicaltrials.gov/ct2/show/NCT04845698
A Mobile Phone App for the Prevention of Type 2 Diabetes in Malaysian Women With Gestational Diabetes Mellitus: Protocol for a Feasibility Randomized Controlled Trial
Authors: Benton Madeleine , Iman Iklil , Goldsmith Kimberley , Forbes Angus , Ching Siew Mooi , Papachristou Nadal Iliatha , Guess Nicola , Murphy Helen R , Mohd Yusof Barakatun-Nisak , Baharom Anisah , Mahamad Sobri Nur Hafizah , Basri Nurul Iftida , Salim Mazatulfazura Sf , Ismail Irmi Zarina , Hassan Faezah , Ismail Khalida , Chew Boon How
Published: April 2022

Background

Over 50% of women with a history of gestational diabetes mellitus (GDM) will develop type 2 diabetes (T2D) in later life. Asian women experience a disproportionate risk of both GDM and T2D compared to women from other ethnic backgrounds. Lifestyle interventions and behavior change can delay or even prevent the onset of T2D. We have developed a digitalized diabetes prevention intervention for the prevention of T2D in Malaysian women with GDM.

Objective

The protocol describes a randomized controlled trial (RCT) to test the feasibility of undertaking a definitive trial of a diabetes prevention intervention, including a smartphone app and group support. Secondary aims are to summarize anthropometric, biomedical, psychological, and lifestyle outcomes overall and by allocation group, and to undertake a process evaluation.

Methods

This is a two-arm parallel feasibility RCT. A total of 60 Malaysian women with GDM will be randomized in the antenatal period to receive the intervention or standard care until 12 months post partum. The intervention is a diabetes prevention intervention delivered via a smartphone app developed based on the Information-Motivation-Behavioral Skills model of behavior change and group support using motivational interviewing. The intervention provides women with tailored information and support to encourage weight loss through adapted dietary intake and physical activity. Women in the control arm will receive standard care. The Malaysian Ministry of Health’s Medical Research and Ethics Committee has approved the trial (NMRR-21-1667-60212).

Results

Recruitment and enrollment began in February 2022. Future outcomes will be published in peer-reviewed health-related research journals and presented at national, regional, or state professional meetings and conferences. This publication is based on protocol version 2, January 19, 2022.

Conclusions

To our knowledge, this will be the first study in Malaysia that aims to determine the feasibility of a digital intervention in T2D prevention among women with GDM. Findings from this feasibility study will inform the design of a full-scale RCT in the future.

Trial Registration

ClinicalTrials.gov NCT05204706; https://clinicaltrials.gov/ct2/show/NCT05204706

International Registered Report Identifier (IRRID)

PRR1-10.2196/37288
Countermeasures for “East Turkistan” Terrorism
Authors: Sun Shengkun
Published: April 2022

Under China’s high-pressure counter-terrorism situation, the characteristics of “East Turkistan” terrorist organizations’ looseness, risk liquidity and behavioral uncertainty are becoming more and more obvious, challenging the established counter-terrorism model. To adapt to the new situation and new risks, we must not only rely on military means to suppress East Turkistan terrorism, but also strengthen the social governance of East Turkistan terrorism and dismantle its social base and extremist ideology, so as to break away from the “more counter-terrorism” approach. The more we fight against terrorism, the more we can cut off the root of the development of East Turkistan terrorism.
NEW PHOTOMETRY AND SPECTROSCOPY OF DW CANCRI
Authors: Ramírez S. H. , Segura Montero O. , Michel R. , Echevarría J.
Published: April 2022

We present new observations of the cataclysmic variable DW Cancri, after the system recovered from a low state. We performed a power spectrum analysis that reveals a clear signal of the 38 min spin period in our photometric data. Our spectroscopic power spectrum search was consistent with studies performed before the low state, showing the orbital and spin modulations. Our Doppler Tomography study exhibits a disc structure and an enhanced asymmetric region, possibly related to a hot spot component. Furthermore, a wavelet transform analysis reveals the 70 min spin-orbit beat period. We interpret these results as an indication of a partial recovery of the system. However, DW Cnc does not yet show all the original photometric modulations reported before the low state. Thus, we propose further observations to elucidate if such original signals require more time to reactivate.
MORPHOLOGICAL STUDY OF A SAMPLE OF DWARF TIDAL GALAXIES USING THE C-A PLANE
Authors: Vega-Acevedo I. , Hidalgo-Gámez A. M.
Published: April 2022

In this investigation, we determined the Concentration (C) and Asymmetry (A) parameters in a sample of tidal dwarf galaxies (TDG) or candidate galaxies. Most of the galaxies in the sample were found to be in a very precise region of the C-A plane, which clearly separates them from other galaxies. In addition, the stellar mass (Mstar) and the star formation rate (SFR) in the sample were determined using optical images and GALEX observations. The main results are: the Mstar and the SFR in the TDG sample do not follow a linear correlation with the C and A respectively, as observed in the rest of galaxies, and the Mstar and the SFR have a linear correlation similar to that followed by galaxies at high redshift. Then, we can conclude that the C-A plane can be a useful method for the morphological identification of candidates for TDG or dwarf objects from very turbulent environments.
TEMPERATURE DISCREPANCY WITH PHOTOIONIZATION MODELS OF THE NARROW-LINE REGION
Authors: Binette L. , Villar Martín M. , Magris C. G. , Martínez-Paredes M. , Alarie A. , Rodríguez Ardila A. , Villicaña-Pedraza I.
Published: April 2022

Using published work on the narrow-line region of Active Galactic Nuclei, a comparison is carried out among the [OIII] λ4363Å/5007Å ratios (ROIII) observed in quasars, Seyfert 2's and the spatially resolved ENLR plasma. Using the weak [ArIV] λ4711Å/λ4740Å doublet observed by Koski (1978) among Seyfert 2's, we find evidence of a Narrow-Line Region (NLR) populated by low density emission clouds (≲ 104 cm-3). After considering calculations of the [Ar] and [OIII] ratios that assume a powerlaw distribution of plasma densities, no evidence of collisional deexcitation is found. The plasma temperature that is inferred is 13 500 °K, which is problematic to reproduce with standard photoionization calculations. The simplest interpretation for the near coincidence of the ROIII ratios among the ENLR and Seyfert 2 measurements (ROIII ≃ 0.017) is that the low density regime applies to both plasmas.
Optimizing Cache Hit Ratio in Edge Computing Using Machine Learning Techniques
Authors: Khan Muddasar , Wei Prof Wei , Naz Falak
Published: April 2022

Abstract: Over the past few years, computing points in cloud computing systems have begun to extend to terminal nodes in network infrastructure as more powerful and smarter devices become available. This extent to computing power has triggered a variety of terminology, including fog computers, Nano data centers, and cloudlets. Edge caching has aroused increased interest in research as mobile traffic grows rapidly and more traffic is devoted to serving content (as opposed to communication between end nodes). By placing popular content in the cache for edge servers that are closer to the end of the user, a wireless network can simultaneously achieve a smaller content delivery delay for the users and an improved spectrum and energy efficiency. Keywords: edge computing, fog computers, Nano data centers, machine learning algorithm
Relationship between Widal test Titer Levels with Lymphocyte and Platelet Count Fever Patients in Typhoid at Porsea Regional General Hospital, North Sumatra
Authors: Sirait Margareth Duma Sari
Published: April 2022

Abstract: Introduction: Typhoid fever is a a bacterial infection caused by Salmonella typhi. Salmonella typhi infection is bacteremic which enters the small intestine and then spreads to the bone marrow. Diagnosis of Samonella typhi using Widal test and routine blood tests. Widal test and routine blood tests to see the body's mechanism against lymphocytes and platelets which are produced in the bone marrow and function as the body's defense against infection. When these bacteria reach the bone marrow, it will inhibit the formation of lymphocytes and platelets. This is also due to the presence of endotoxin from bacteria so that in cases of typhoid , lymphocytosis and thrombocytopenia occur. Objective: To determine the relationship between Widal titer and the number of lymphocytes and platelets in patients with typhoid fever. Research methods: Analytical Observation. The number of samples used as many as 24 samples using primary data. The data collected is in the form of Widal titer with the number of lymphocytes and platelets. Then processed using the Pearson Correlation. Results: The mean of lymphocytes on the O antigen with a titer of 1/160 was 24.84%, a titer of 1/320 was 43.95%, the mean of platelets with a titer of 1/160 was 312,000 gL and a titer of 1/320 was 230,750 gL. While on H antigen the mean number of lymphocytes with a titer of 1/160 is 35.48% and a titer of 1/320 is 39.86%. The mean platelet count with a titer of 1/160 is 196,670 gL and a titer of 1/320 is 158,000 gL. Statistical test results p>0.05. Conclusion: There is no relationship between Widal titer and the number of lymphocytes and platelets in typhoid at the Gunungsari Health Center, West Lombok. Keywords : Typhoid fever, Widal, Lymphocytes, Platelets
Credit Card Fraud Detection
Authors: Gurav Prof. R. B. , Badhe Mrs. Shraavani Mandar , Nagtilak Mrs. Sakshi , Pandit Sonawane Mr. Sarthak , Agarwal Mr. Siddhant
Published: April 2022

Abstract: Now a day’s online transactions have become an important and necessary part of our lives. It is vital that credit card companies are able to identify fraudulent credit card transactions so that customers are not charged for items that they did not purchase. As frequency of transactions is increasing, number of fraudulent transactions are also increasing rapidly. Such problems can be tackled with Machine Learning with its algorithms. This project intends to illustrate the modelling of a data set using machine learning with Credit Card Fraud Detection. The Credit Card Fraud Detection Problem includes modelling past credit card transactions with the data of the ones that turned out to be fraud. This model is then used to recognize whether a new transaction is fraudulent or not. Our objective here is to detect 100% of the fraudulent transactions while minimizing the incorrect fraud classifications. Credit Card Fraud Detection is a typical sample of classification. In this process, we have focused on analyzing and preprocessing data sets as well as the deployment of multiple anomaly detection algorithms such as Local Outlier Factor and Isolation Forest algorithm on the PCA transformed Credit Card Transaction data. Keywords: Credit Card, Python, Detection
Touch Controlled Wheelchair
Authors: Tiple Mr. Arpit , Pakade Mr. Akshay , Madavi Miss Shilpa , Khond Mr. Anurag , Potdukhe Mr. Tejas , Nandanwar Mr. Kunal , Thorat Miss Ashwini , Jais Prof. Vipin
Published: April 2022

Abstract: Smart robotic wheelchair has a great significance in life of a disabled person. With several merits, a wheelchair becomes a dilemma for a disabled person when comes to self-propulsion. This project describes an economical solution of robot control systems. The presented wheelchair control system can be used for different sophisticated robotic applications. The automatic robotic wheelchair comprises of the features like sensing hindrances and circuitry to avoid colliding to obstacle and emergency calling. Implementing embedded systems solution on self-propelled wheelchair enhances upgradability. This paper briefs a multifunctional wheelchair for disabled mob using, touch screen, ultrasonic sensor and Motor driver system interfaced through microcontroller which ultimately abolishes switching technology and thus optimizing hardware cost. Obstacle avoidance facility enables to drive safely in unknown as well as dynamic environments. Keywords: Easy navigation, Obstacle avoidance, Touch screen, Motors
IoT Based Bot for Flood Water Cleaning and Treatment
Authors: Patel Yuvraj , Pandita Deepanshu , Nair Ashwin , Mathapati Nikhil , Cherian Mimi
Published: April 2022

Abstract: This survey paper is an attempt to construct a bot that can clean and treat flood water. During floods, water becomes contaminated with waste because the use of plastic and other harmful materials is increasing uncontrollably in many floodaffected areas. Toxins from these elements disrupt the ecosystem and endanger human health, leading to cancer, congenital malformations, and immune system problems. Water scarcity is a severe concern in modern society that requires a lot of attention. As a result, flood water must be treated. By collecting the waste treatment of water using chemicals, a bot for flood water cleaning and treatment utilizing IoT is created. Keywords: Internet of Things, Flood Waste, Water Treatment, Bot, Bluetooth, Arduino
Smart Agriculture Suggestion System
Authors: Kashyap Vipul , Darji Dhruv , Mistry Yash , Dhavale Prof. Chhaya
Published: April 2022

Abstract: Agriculture is a career that has been performed for many years. However, as time passes, people's confidence in this profession is eroding. One of the reasons for this is that agriculture is practiced in an unscientific manner. Traditional approaches are getting less successful as time passes. To address this, the method described here analyses the current environmental and soil parameters and predicts the best crop for the scenario. This technology is intended to assist farmers by serving as a gateway between them and all accessible information. The project's main goal is to gather information from many sources on the internet and display it to the user in a user-friendly and understandable manner. This site will serve as a resource for farmers around the country, as 3well as a platform for them to connect and share their important resources and expertise with one another. We also want to dedicate a part of this programme solely to crop, equipment, and labour management. We want to make resource collection and farm management considerably more efficient. Keywords: Agriculture, Management, Sustainable Web, Android
A Study of Garbage Enzyme Solution
Authors: Jabhade Shailesh B , Bhosale Ajinkya C , Maske Prasad B , Pavane Shashikant B , Mane Swati
Published: April 2022

Abstract: Garbage enzyme is obtained by fermenting fruit and vegetable wastes. This alternative method of biological recovery of organic waste may provide a solution to waste minimization and reduction since a large proportion of municipal solid waste consists of food waste. A study was conducted to assess the implementation of garbage enzyme making and usage as an initiative to reduce the amount of municipal solid waste generated by a hawker community. It was found that practical values, communal spirit and awareness of environmental consequences were among the factors that encourage the practice of garbage enzyme making, while ignorance, time and convenience factors hinder garbage enzyme making and usage. Taking these factors into consideration, municipalities could promote garbage enzyme as a viable method in reducing the amount of MSW generated. Keywords: garbage enzyme, anti-microbial.
Media Linguistics and Its Role in The Language of Modern Mass Media
Authors: Berdimurodovich Khodjayorov Malik
Published: April 2022

Abstract: The study of media text led to the allocation of a new section of linguistics. Medialinguistics studies the language of mass communication and media speech. Modern foreign studies speak of linguistic imperialism and the English-speaking influence on the world media. Stylistic aspects of media speech in media linguistics has an important role for the expression of opinion and evaluation in information and analytical texts is played by ideologically-modal vocabulary. The article considers this influence on the example of the Uzbek media. Keywords: media linguistics, mass media language, mass communication, world view, linguistic imperialism.
PENGARUH KEMISKINAN, PERTUMBUHAN EKONOMI, DAN PENGELUARAN PEMERINTAH TERHADAP KEMISKINAN DI KALIMANTAN TIMUR
Authors: Alviano Reynaldy Aldi , Aini Ida Nur , Kusuma Hendra
Published: April 2022

In the province of East Kalimantan, poverty is a problem that still cannot be overcome. Poverty in the province of East Kalimantan from year to year is still high, which is not in line with economic growth which is also high in East Kalimantan compared to other Kalimantan Provinces. Poverty is high due to unemployment which is also high and government spending also affects poverty in East Kalimantan. The purpose of this research is to determine the effect of unemployment, economic growth, and government spending on poverty in East Kalimantan Province. The data used are secondary data derived from the statistical body (bps) of East Kalimantan and odjk of the finance ministry. The method of analysis uses panel data analysis and fixed-effect models. The results of this study indicate that simultaneous unemployment, economic growth, and government spending affect poverty in East Kalimantan Province. The unemployment variable has a positive and significant effect on poverty, the economic growth variable has a negative and significant effect on poverty, while the government expenditure variable has a negative and significant effect on poverty in East Kalimantan.
ANALISIS KESETARAAN GENDER TERHADAP KEPUTUSAN INVESTASI SAHAM DI DANAREKSA SEKURITAS
Authors: Dheaanty Mahrifha , Abdhullah M. Faisal
Published: April 2022

This study was conducted to analyze gender equality in stock investment decisions in Danareksa Securities, which are measured using financial factors (financial analysis and financial literacy) and non-financial factors (self-confidence and intuition) as independent variables and stock investment decisions as independent variables. This research uses a quantitative descriptive method. This research is conducted to study certain objects by distributing questionnaires which are then interpreted so that the results of the research and conclusions drawn merely describe (expose) a symptom of events as they really are. The results of this study indicate that there is a positive influence of the independent variables (intuition, financial analysis, financial literacy, and self-confidence) on investment decisions at Danareksa Sekuritas. However, the linear regression equation shows a significant value at a constant less than 0.05 so it cannot be used to predict.
ANALISIS TINGKAT DAYA SERAP ANGGARAN BELANJA DAERAH DI KOTA MALANG
Authors: Krisdiyanawati Luluk , Abdullah M. Faisal , Syaifullah Yunan
Published: April 2022

The purpose of this research is to understand the level of absorptive capacity of regional expenditure budgets in Malang City and to understand the effect  of planning  variables, procurement of goods and services variables, and human sesource variables on the  absorption of regional expenditure budgets in Malang.  This type of research  is  quantitative  research. The population in this research were 20 regional work units in Malang in the form of Agency and Department. The sample of this research is the Regional  Financial and Asset Agency, Planning Research and Development Agency, Education and Culture Department, Health Department, and Environment Department in Malang City with  respondents occupying positions related to the budget, namely the authority  of  budgets users, officials making commitments, the technical executive officer of the  activity, the official signing the payment order, and the treasurer of the expenditure.The technical analysis used is multiple linear regression. The results of this research indicated that the human resources variable has a significant  positive effect on the absorption of regional budgets. While the planning variable and the procurement  of goods and services variable do not significantly positive influence the absorption capacity of the budget.
ANALISIS PENYALURAN KREDIT PADA BANK PERKREDITAN RAKYAT (BPR) DI JAWA TIMUR
Authors: Sih Kinar , Abdullah Faisal
Published: April 2022

This research aims to analyze the influencing factors lending at the Rural Bank (BPR) in East Java Provience, a total population recorded in desember 2018 of 1583 offices spread in East Java Province. The variable used are Third Party Funds (DPK), BI-Rate, and Non Performing Loan (NPL). The source of this research data comes from the official website of the Central Statistics aviable in the Financial Services Authority (OJK). The period of the research is amounted 14 years, starting from 2005 – 2018. The analysis technique of this research is the Multiple Linear Regression technique. Based on results of this research, it can be stated simultaneously and partyally that the independent variable has a significant effect on lending, when the variable Third Party Funds (DPK) and BI-Rate both have a significant positive effect with probability of 0.0000 and 0.0088. while the Non Performing Loan (NPL) variable has a significant negative effect with a probability of 0.0001
Pengaruh Nilai Tukar, PDB, Inflasi dan Harga Emas di Korea Stock Exchange
Authors: Walidain Birrul , Zuhroh Idah
Published: April 2022

Stock Price Index is a reflection of the economic conditions of a country when the stock price index shows an increase means that the economy is conducive and vice versa. This study aims to analyze the development of macroeconomic factors on the stock price index on the Korea Stock Exchange. The data used in this study are secondary in the form of data from quarter I-IV during the period 2014 - 2018. Data analysis techniques using multiple linear regression analysis with the help of statistical software program Eviews9. The results of the study show that Exchange Rates, Gross Domestic Product (GDP), Inflation, and World Gold Prices simultaneously influence the Stock Price Index on the Korea Stock Exchange with a calculated F-value (0.002159) < 0.05. T-test results show that Exchange Rates have a significant negative effect. GDP has a significant positive effect on the stock price index on the Korea Stock Exchange, then inflation and world gold prices do not have an influence on the stock price index on the Korea Stock Exchange.
ANALISIS PERTUMBUHAN EKONOMI, PENDIDIKAN DAN INDEKS PEMBANGUNAN MANUSIA TERHADAP TINGKAT KEMISKINAN DI MADURA
Authors: Sari Nada Kirana , Susilowati Dwi , Arifin Zainal
Published: April 2022

One of the main indicators of the success of a development is the reduction in poverty levels. Regency on Madura Island is the region with the highest poverty rate in East Java Province. The purpose of this study was to analyze the effect of economic growth, education and human development index on the poverty level of districts on the island of Madura 2012-2018. In this study using quantitative research and secondary data types sourced from the Central Statistics Agency. The regression analysis used is panel data with the chosen model that is Random Effect. The results of this study indicate that: 1). Partially economic growth, education and HDI have a negative and significant influence on the poverty level of districts on the island of Madura 2012-2018 2). Simultaneously economic growth, education and HDI have an influence on district poverty levels on the island of Madura 2012-2018. In this study concluded that the economic growth variable has a negative and significant effect on poverty levels with a probability value of 0,0001 and a coefficient of -0.180288. The education variable that uses the average length of school has a negative and significant effect on poverty levels with a probability value of 0.0000 and a coefficient of -2.174169. The human development index variable has a negative and significant effect on poverty levels with a probability value of 0,0001 and a coefficient of -0.540652.
PENGARUH GDP DAN NILAI TUKAR NEGARA MITRA DAGANG TERHADAP EKSPOR KARET INDONESIA
Authors: Andriantoni Nico , Hidayat Wahyu , Arifin Zainal
Published: April 2022

International trade is one of the economic activities that plays an important role for a country. The benefits of international trade are related to economic growth, national development and national welfare. The condition of limited resources is no longer a barrier to meeting the needs of a country with exchange and trade. Rubber is one of the leading export commodities for the Indonesian plantation sector. Indonesia is one of the main producers of natural rubber number two in the world after Thailand. The purpose of this study was to determine the effect of Gross Domestic Product and the exchange rate of trading partner countries on Indonesian Rubber exports. The type of data used is panel data of Indonesia Rubber export partner countries in 2009-2018. The method used is panel data regression. The results showed that the export of Indonesian Rubber with Gross Domestic Product was positive and significant. And the exchange rate also has a positive and significant effect
PENGARUH MODAL DAN TENAGA KERJA TERHADAP PRODUKSI INDUTRI MEUBEL BUKIR KOTA PASURUAN
Authors: Febrianto Achmadi Akhimullah , Riyanto Wahyu Hidayat , Suliswanto Muhammad Sri Wahyudi
Published: April 2022

This study is aimed at determining the effect of capital and labor variables on the amount of industrial furniture production in Bukir Sub-District, Gadingrejo District, Pasuruan City, the magnitude of the level of input and return to scale elasticity that occurred in the industry. This research used quantitative research, data obtained by questionnaire, and interview. The method used in sampling is to take a random sample of the entire population with a total sample of 42 furniture industries. The data analysis technique used is the Cobb-Douglas production function with multiple regression analysis. The results showed that capital and labor simultaneously affect the furniture industry's production with an F-value (0.0001<0.05). The result of the t-test showed that the capital variable partially has a significant effect on the production of the furniture industry with a value of prob (0.0393<0.05). The result of the t-test showed that the labor variable partially has a significant effect on the production of the furniture industry with a value of prob (0.0197<0.05). The magnitude of the elasticity of capital input is 0.401 and labor input is 0.664, the value is less than 1 so it is inelastic. Returning to scale showed that the furniture industry is on an increasing scale.
ANALISIS KELAYAKAN USAHA INDUSTRI RUMAH TANGGA SARUNG TENUN ALAT TRADISIONAL DESA GEDANGKULUT GRESIK
Authors: Alfizah Fatikah Nur , Riyanto Wahyu Hidayat , Sari Novi Primita
Published: April 2022

The development of UMKM for traditional tool woven sarongs in Gresik Regency is the most important part in driving economic development, but in the development process, especially in Gedangkulut Village, the traditional tool sarong weaving business does not have the ability to develop forward in terms of marketing and in managing financial management. The purpose of this study was to study the feasibility of a traditional home industry industry of woven gloves in the traditional village of Gedangkulut Village, Cerme District, Gresik Regency, by searching for business or project information. The method used in this research is quantitative and qualitative descriptive. The sample used was 15 respondents. The study uses primary and secondary data. The analytical tool used is to calculate the micro with the formula π = TR - TC, benefit cost ratio, salary period, net present value and return on investment. The results showed the characteristics of the business did not involve the administration of personal finance still united with the financial business, entrepreneurs who did not have a business permit, did not need a business organizational structure and the results of the business feasibility calculations resulted in an average amount of Rp. 483,371,863 for 5 years using the b / c ratio of Rp. 10.8 which means the business is feasible to be carried out, the paybeck period is obtained an average time of less than one year which means good business, net present value is obtained with a positive number of Rp. 7,095,083,053.67 which means the investment is received and the return on investment is obtained by an average of 10.2% which means the ratio is smaller or less good.