bluuebunny/crossref_metadata_2025 huggingface dataset:
CD33 Expression and Gentuzumab Ozogamicin in Acute Myeloid Leukemia: Two Sides of the Same Coin
Authors: Molica Matteo , Perrone Salvatore , Mazzone Carla , Niscola Pasquale , Cesini Laura , Abruzzese Elisabetta , de Fabritiis Paolo
Published: June 2021

Acute myeloid leukemia (AML), the most frequent acute leukemia in adults, has been historically treated with infusional cytarabine (ara-c) + daunorubicin (3 + 7) for at least 40 years. The first “target therapy” to be introduced was the monoclonal anti-CD33 gemtuzumab ozogamicin (GO) in 2004. Unfortunately, in 2010 it was voluntarily withdrawn from the market both for safety reasons related to potential liver toxicity and veno-occlusive disease (VOD) and because clinical studies failed to confirm the clinical benefit during induction and maintenance. Seven years later, GO was re-approved based on new data, including insights into its mechanism of action on its target receptor CD33 expressed on myeloid cells. The present review focuses on current biological information and clinical data from several studies investigating GO. Cytogenetic, molecular, and immunophenotypic data are now able to predict the potential positive advantages of GO, with the exception of high-risk AML patients who do not seem to benefit. GO can be considered a ‘repurposed drug’ that could be beneficial for some patients with AML, mostly in combination with new drugs already approved or currently in testing.
Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma
Authors: Hering Nina A. , Liu Verena , Kim Rayoung , Weixler Benjamin , Droeser Raoul A. , Arndt Marco , Pozios Ioannis , Beyer Katharina , Kreis Martin E. , Seeliger Hendrik
Published: June 2021

Cholinergic signaling via the muscarinic M3 acetylcholine receptor (M3R) is involved in the development and progression of colorectal cancer (CRC). The present study aimed to analyze the blocking of M3R signaling in CRC using darifenacin, a selective M3R antagonist. Darifenacin effects were studied on HT-29 and SW480 CRC cells using MTT and BrdU assays, Western blotting and real time RT-PCR. In vivo, blocking of M3R was assessed in an orthotopic CRC xenograft BALB/cnu/nu mouse model. M3R expression in clinical tumor specimens was studied by immunohistochemistry on a tissue microarray of 585 CRC patients. In vitro, darifenacin decreased tumor cell survival and proliferation in a dose-dependent manner. Acetylcholine-induced p38, ERK1/2 and Akt signaling, and MMP-1 mRNA expression were decreased by darifenacin, as well as matrigel invasion of tumor cells. In mice, darifenacin reduced primary tumor volume and weight (p < 0.05), as well as liver metastases, compared to controls. High expression scores of M3R were found on 89.2% of clinical CRC samples and correlated with infiltrative tumor border and non-mucinous histology (p < 0.05). In conclusion, darifenacin inhibited components of tumor growth and progression in vitro and reduced tumor growth in vivo. Its target, M3R, was expressed on the majority of CRC. Thus, repurposing darifenacin may be an attractive addition to systemic tumor therapy in CRC patients expressing M3R.
Next-Generation Biomarkers for Cholangiocarcinoma
Authors: Rodrigues Pedro M. , Vogel Arndt , Arrese Marco , Balderramo Domingo C. , Valle Juan W. , Banales Jesus M.
Published: June 2021

The increasing mortality rates of cholangiocarcinoma (CCA) registered during the last decades are, at least in part, a result of the lack of accurate non-invasive biomarkers for early disease diagnosis, making the identification of patients who might benefit from potentially curative approaches (i.e., surgery) extremely challenging. The obscure CCA pathogenesis and associated etiological factors, as well as the lack of symptoms in patients with early tumor stages, highly compromises CCA identification and to predict tumor development in at-risk populations. Currently, CCA diagnosis is accomplished by the combination of clinical/biochemical features, radiological imaging and non-specific serum tumor biomarkers, although a tumor biopsy is still needed to confirm disease diagnosis. Furthermore, prognostic and predictive biomarkers are still lacking and urgently needed. During the recent years, high-throughput omics-based approaches have identified novel circulating biomarkers (diagnostic and prognostic) that might be included in large, international validation studies in the near future. In this review, we summarize and discuss the most recent advances in the field of biomarker discovery in CCA, providing new insights and future research directions.
Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model
Authors: Vannitamby Amanda , Saad Mohamed I. , Aloe Christian , Wang Hao , Kumar Beena , Vlahos Ross , Selemidis Stavros , Irving Louis , Steinfort Daniel , Jenkins Brendan J. , Bozinovski Steven
Published: June 2021

Tumour-associated neutrophils (TANs) can support tumour growth by suppressing cytotoxic lymphocytes. AT-RvD1 is an eicosanoid that can antagonise neutrophil trafficking instigated by ALX/FPR2 ligands such as serum amyloid A (SAA). We aimed to establish whether SAA and ALOX5 expression associates with TANs and investigate the immunomodulatory actions of AT-RvD1 in vivo. MPO-positive neutrophils were quantified in tumour blocks from lung adenocarcinoma (n = 48) and control tissue (n = 20) by IHC. Tumour expression of SAA and ALOX5 were analysed by RTqPCR and an oncogenic KrasG12D lung adenocarcinoma mouse model was used to investigate the in vivo efficacy of AT-RvD1 treatment. ALOX5 expression was markedly reduced in lung adenocarcinoma tumours. The SAA/ALOX5 ratio strongly correlated with TANs and was significantly increased in tumours harbouring an oncogenic KRAS mutation. AT-RvD1 treatment reduced tumour growth in KrasG12D mice, which was accompanied by suppressed cellular proliferation within parenchymal lesions. In addition, AT-RvD1 significantly reduced the neutrophil to lymphocyte ratio (NLR), an established prognostic marker of poor survival in adenocarcinoma. This study identifies a novel molecular signature whereby elevated levels of SAA relative to ALOX5 favour accumulation of TANs. Furthermore, the ALOX5/5-LO enzymatic product, AT-RvD1, markedly reduced the NLR and suppressed tumour growth in KrasG12D mice.
ADCC-Inducing Antibody Trastuzumab and Selection of KIR-HLA Ligand Mismatched Donors Enhance the NK Cell Anti-Breast Cancer Response
Authors: Ehlers Femke A. I. , Beelen Nicky A. , van Gelder Michel , Evers Tom M. J. , Smidt Marjolein L. , Kooreman Loes F. S. , Bos Gerard M. J. , Wieten Lotte
Published: June 2021

Natural killer (NK)-cell-based immunotherapies are an attractive treatment option for cancer. We previously showed that alloreactive mouse NK cells cured mice of 4T1 breast cancer. However, the tumor microenvironment can inhibit immune responses, and these suppressive factors must be overcome to unfold the NK cells’ full anti-tumor potential. Here, we investigated the combination of antibody-dependent cellular cytotoxicity (ADDC) and the selection of KIR-HLA-ligand mismatched NK cells to enhance NK cell anti-breast cancer responses in clinically relevant settings. Donor-derived and IL-2-activated NK cells were co-cultured with patient-derived breast cancer cells or cell lines MCF7 or SKBR3 together with the anti-HER2 antibody trastuzumab. NK cells mediated anti-breast cancer cytotoxicity under normoxic and hypoxic conditions. Under both conditions, trastuzumab vigorously enhanced NK cell degranulation (CD107a) against HER2-overexpressing SKBR3 cells, but we observed a discrepancy between highly degranulating NK cells and a rather modest increase in cytotoxicity of SKBR3. Against patient-derived breast cancer cells, the anti-tumor efficacy was rather limited, and HLA class I expression seemed to contribute to inhibited NK cell functionality. KIR-ligand-mismatched NK cells degranulated stronger compared to the matched NK cells, further highlighting the role of HLA. In summary, trastuzumab and KIR-ligand-mismatched NK cells could be two strategies to potently enhance NK cell responses to breast cancer.
Multiple Therapeutic Applications of RBM-007, an Anti-FGF2 Aptamer
Authors: Nakamura Yoshikazu
Published: June 2021

Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis, but is not the only player with an angiogenic function. Fibroblast growth factor-2 (FGF2), which was discovered before VEGF, is also an angiogenic growth factor. It has been shown that FGF2 plays positive pathophysiological roles in tissue remodeling, bone health, and regeneration, such as the repair of neuronal damage, skin wound healing, joint protection, and the control of hypertension. Targeting FGF2 as a therapeutic tool in disease treatment through clinically useful inhibitors has not been developed until recently. An isolated inhibitory RNA aptamer against FGF2, named RBM-007, has followed an extensive preclinical study, with two clinical trials in phase 2 and phase 1, respectively, underway to assess the therapeutic impact in age-related macular degeneration (wet AMD) and achondroplasia (ACH), respectively. Moreover, showing broad therapeutic potential, preclinical evidence supports the use of RBM-007 in the treatment of lung cancer and cancer pain.
High SPINK4 Expression Predicts Poor Outcomes among Rectal Cancer Patients Receiving CCRT
Authors: Chen Tzu-Ju , Tian Yu-Feng , Chou Chia-Lin , Chan Ti-Chun , He Hong-Lin , Li Wan-Shan , Tsai Hsin-Hwa , Li Chien-Feng , Lai Hong-Yue
Published: June 2021

Background: Patients with rectal cancer can prospectively be favored for neoadjuvant concurrent chemoradiotherapy (CCRT) to downstage before a radical proctectomy, but the risk stratification and clinical outcomes remain disappointing. Methods: From a published rectal cancer transcriptome dataset (GSE35452), we highlighted extracellular matrix (ECM)-linked genes and identified the serine protease inhibitor Kazal-type 4 (SPINK4) gene as the most relevant among the top 10 differentially expressed genes associated with CCRT resistance. We accumulated the cases of 172 rectal cancer patients who received neoadjuvant CCRT followed by surgery and collected tumor specimens for the evaluation of the expression of SPINK4 using immunohistochemistry. Results: The results revealed that high SPINK4 immunoexpression was significantly related to advanced pre-CCRT and post-CCRT tumor status (both p < 0.001), post-CCRT lymph node metastasis (p = 0.001), more vascular and perineurial invasion (p = 0.015 and p = 0.023), and a lower degree of tumor regression (p = 0.001). In univariate analyses, high SPINK4 immunoexpression was remarkably correlated with worse disease-specific survival (DSS) (p < 0.0001), local recurrence-free survival (LRFS) (p = 0.0017), and metastasis-free survival (MeFS) (p < 0.0001). Furthermore, in multivariate analyses, high SPINK4 immunoexpression remained independently prognostic of inferior DSS and MeFS (p = 0.004 and p = 0.002). Conclusion: These results imply that high SPINK4 expression is associated with advanced clinicopathological features and a poor therapeutic response among rectal cancer patients undergoing CCRT, thus validating the prospective prognostic value of SPINK4 for those patients.
New Species and New Records of Sponge-Inhabiting Barnacles (Cirripedia, Balanidae, Acastinae) from Australia
Authors: Hosie Andrew , Fromont Jane , Munyard Kylie , Jones Diana
Published: June 2021

The subfamily Acastinae contains a diverse group of barnacles that are obligate symbionts of sponges and alcyonacean and antipatharian corals. Integrating morphological and genetic (COI) data to compare against known species, this paper reports on nine species of sponge-inhabiting barnacles of the subfamily Acastinae, including three undescribed species (Acasta caveata sp. nov., Euacasta acutaflava sp. nov., and E. excoriatrix sp. nov.) and three species previously not recorded in Australian waters (A. sandwichi, Pectinoacasta cancellorum, and P. sculpturata). The new species are distinguished from similar species by a suite of morphological characters as well as genetic distances. A lectotype for Pectinoacasta cancellorum is designated. Sponge hosts were identified for all specimens where possible and are represented by 19 species from eight families and five orders.
DNA Barcodes Applied to a Rapid Baseline Construction in Biodiversity Monitoring for the Conservation of Aquatic Ecosystems in the Sian Ka’an Reserve (Mexico) and Adjacent Areas
Authors: Valdez-Moreno Martha , Mendoza-Carranza Manuel , Rendón-Hernández Eduardo , Alarcón-Chavira Erika , Elías-Gutiérrez Manuel
Published: June 2021

This study is focused on the aquatic environments of the Sian Ka’an reserve, a World Heritage Site. We applied recently developed protocols for the rapid assessment of most animal taxa inhabiting any freshwater system using light traps and DNA barcodes, represented by the mitochondrial gene Cytochrome Oxidase I (COI). We DNA barcoded 1037 specimens comprising mites, crustaceans, insects, and fish larvae from 13 aquatic environments close or inside the reserve, with a success rate of 99.8%. In total, 167 barcode index numbers (BINs) were detected. From them, we identified 43 species. All others remain as a BIN. Besides, we applied the non-invasive method of environmental DNA (eDNA) to analyze the adult fish communities and identified the sequences obtained with the Barcode of Life Database (BOLD). All round, we found 25 fish species and other terrestrial vertebrates from this region. No alien species was found. After comparing the BINs from all systems, we found that each water body was unique with respect to the communities observed. The reference library presented here represents the first step for future programs to detect any change in these ecosystems, including invasive species, and to improve the knowledge of freshwater zooplankton, enhancing the task of compiling the species barcodes not yet stored in databases (such as BOLD or GenBank).
The Bird Assemblage of the Darwin Region (Australia): What Is the Effect of Twenty Years of Increasing Urbanisation?
Authors: Fischer Sarah E. , Edwards Andrew C. , Weber Patrice , Garnett Stephen T. , Whiteside Timothy G.
Published: June 2021

There has been considerable urban development in the Darwin region over the last twenty years; as for most fauna in Australia since colonisation, the potential effects to the bird assemblage were expected to be disastrous. To provide a broad overview of changes, bird survey data from 1998 and 2018 were extracted from BirdLife Australia’s ‘Atlas of Australian Birds’ database. A total of 165 species were categorised into primary food source feeding guilds and levels of food specialisation. This was integrated into ArcGIS along with land use change mapping from 1998 and 2018 to investigate its impact on bird assemblages. There was no significant change in overall species numbers when all sites were analysed. However, when sites were separated into those with increased urbanisation or decreased greenspace, several sites showed a significant change in the number of species. For the majority of species, analysis of primary food types found no difference in the proportion of species within the assemblages between 1998 and 2018, regardless of the level of urbanisation or greenspace; the exception being those species that primarily feed on insects, where the difference was just significant. An analysis using bird community data sorted into levels of food specialisation also found no difference between 1998 and 2018 despite habitat changes. These findings suggest that although there has been considerable urban development in the Darwin region, bird communities are remaining relatively stable.
Real-Time Tool Detection for Workflow Identification in Open Cranial Vault Remodeling
Authors: Pose Díez de la Lastra Alicia , García-Duarte Sáenz Lucía , García-Mato David , Hernández-Álvarez Luis , Ochandiano Santiago , Pascau Javier
Published: June 2021

Deep learning is a recent technology that has shown excellent capabilities for recognition and identification tasks. This study applies these techniques in open cranial vault remodeling surgeries performed to correct craniosynostosis. The objective was to automatically recognize surgical tools in real-time and estimate the surgical phase based on those predictions. For this purpose, we implemented, trained, and tested three algorithms based on previously proposed Convolutional Neural Network architectures (VGG16, MobileNetV2, and InceptionV3) and one new architecture with fewer parameters (CranioNet). A novel 3D Slicer module was specifically developed to implement these networks and recognize surgical tools in real time via video streaming. The training and test data were acquired during a surgical simulation using a 3D printed patient-based realistic phantom of an infant’s head. The results showed that CranioNet presents the lowest accuracy for tool recognition (93.4%), while the highest accuracy is achieved by the MobileNetV2 model (99.6%), followed by VGG16 and InceptionV3 (98.8% and 97.2%, respectively). Regarding phase detection, InceptionV3 and VGG16 obtained the best results (94.5% and 94.4%), whereas MobileNetV2 and CranioNet presented worse values (91.1% and 89.8%). Our results prove the feasibility of applying deep learning architectures for real-time tool detection and phase estimation in craniosynostosis surgeries.
Performance Optimizations with Single-, Bi-, Tri-, and Quadru-Objective for Irreversible Diesel Cycle
Authors: Shi Shuangshuang , Chen Lingen , Ge Yanlin , Feng Huijun
Published: June 2021

Applying finite time thermodynamics theory and the non-dominated sorting genetic algorithm-II (NSGA-II), thermodynamic analysis and multi-objective optimization of an irreversible Diesel cycle are performed. Through numerical calculations, the impact of the cycle temperature ratio on the power density of the cycle is analyzed. The characteristic relationships among the cycle power density versus the compression ratio and thermal efficiency are obtained with three different loss issues. The thermal efficiency, the maximum specific volume (the size of the total volume of the cylinder), and the maximum pressure ratio are compared under the maximum power output and the maximum power density criteria. Using NSGA-II, single-, bi-, tri-, and quadru-objective optimizations are performed for an irreversible Diesel cycle by introducing dimensionless power output, thermal efficiency, dimensionless ecological function, and dimensionless power density as objectives, respectively. The optimal design plan is obtained by using three solution methods, that is, the linear programming technique for multidimensional analysis of preference (LINMAP), the technique for order preferences by similarity to ideal solution (TOPSIS), and Shannon entropy, to compare the results under different objective function combinations. The comparison results indicate that the deviation index of multi-objective optimization is small. When taking the dimensionless power output, dimensionless ecological function, and dimensionless power density as the objective function to perform tri-objective optimization, the LINMAP solution is used to obtain the minimum deviation index. The deviation index at this time is 0.1333, and the design scheme is closer to the ideal scheme.
Carbon Footprint for Mercury Capture from Coal-Fired Boiler Flue Gas
Authors: Gazda-Grzywacz Magdalena , Winconek Łukasz , Burmistrz Piotr
Published: June 2021

Power production from coal combustion is one of two major anthropogenic sources of mercury emission to the atmosphere. The aim of this study is the analysis of the carbon footprint of mercury removal technologies through sorbents injection related to the removal of 1 kg of mercury from flue gases. Two sorbents, i.e., powdered activated carbon and the coke dust, were analysed. The assessment included both direct and indirect emissions related to various energy and material needs life cycle including coal mining and transport, sorbents production, transport of sorbents to the power plants, and injection into flue gases. The results show that at the average mercury concentration in processed flue gasses accounting to 28.0 µg Hg/Nm3, removal of 1 kg of mercury from flue gases required 14.925 Mg of powdered activated carbon and 33.594 Mg of coke dust, respectively. However, the whole life cycle carbon footprint for powdered activated carbon amounted to 89.548 Mg CO2-e·kg−1 Hg, whereas for coke dust this value was around three times lower and amounted to 24.452 Mg CO2-e·kg−1 Hg. Considering the relatively low price of coke dust and its lower impact on GHG emissions, it can be found as a promising alternative to commercial powdered activated carbon.
Anaerobic Degradation of Environmentally Hazardous Aquatic Plant Pistia stratiotes and Soluble Cu(II) Detoxification by Methanogenic Granular Microbial Preparation
Authors: Havryliuk Olesia , Hovorukha Vira , Savitsky Oleksandr , Trilis Volodymyr , Kalinichenko Antonina , Dołhańczuk-Śródka Agnieszka , Janecki Daniel , Tashyrev Oleksandr
Published: June 2021

The aquatic plant Pistia stratiotes L. is environmentally hazardous and requires effective methods for its utilization. The harmfulness of these plants is determined by their excessive growth in water bodies and degradation of local aquatic ecosystems. Mechanical removal of these plants is widespread but requires fairly resource-intensive technology. However, these aquatic plants are polymer-containing substrates and have a great potential for conversion into bioenergy. The aim of the work was to determine the main patterns of Pistia stratiotes L. degradation via granular microbial preparation (GMP) to obtain biomethane gas while simultaneously detoxifying toxic copper compounds. The composition of the gas phase was determined via gas chromatography. The pH and redox potential parameters were determined potentiometrically, and Cu(II) concentration photocolorimetrically. Applying the preparation, high efficiency of biomethane fermentation of aquatic plants and Cu(II) detoxification were achieved. Biomethane yield reached 68.0 ± 11.1 L/kg VS of Pistia stratiotes L. biomass. The plants’ weight was decreased by 9 times. The Cu(II) was completely removed after 3 and 10 days of fermentation from initial concentrations of 100 ppm and 200 ppm, respectively. The result confirms the possibility of using the GMP to obtain biomethane from environmentally hazardous substrates and detoxify copper-contaminated fluids.
Shading and Masking of PV Collectors on Horizontal and Sloped Planes Facing South and North—A Comparative Study
Authors: Swaid Saeed , Appelbaum Joseph , Aronescu Avi
Published: June 2021

With the increase in PV system installations, the available free land and rooftops for these systems may become scarcer, and therefore sloped fields facing the north may be utilized for that purpose. In deployments of PV collectors in multiple rows, either on horizontal or sloped planes, the second and subsequent rows are subject to two effects: shading and masking. Both effects reduce the electric energy generated by the PV systems. Multiple rows of collectors are deployed on horizontal planes and on sloped planes facing south, and literature on the topic has been published. No literature deals analytically with deployments of PV fields on north-facing slopes in the northern hemisphere, to the best of our knowledge. The present study develops explicit analytical expressions for the shadow height and length cast on a collector row by a row in front in multiple-row PV systems installed on slopes facing north. In addition, analytical expressions are developed for row spacing and sky view factors, altogether leading consequently to the determination of shading and masking losses. Having the developed expressions, a comparison was made between PV deployments on north-facing sloped planes to PV deployments on horizontal and south-facing slopes regarding shading and masking losses. The main finding is that the percentage of masking losses (diffuse radiation) may exceed the percentage of shading losses (beam radiation) in PV fields. At the local site 32∘ N, collector inclination angle β=25∘ and sloped-plane ε=10∘, for example, the percentage of masking losses for a horizontal plane is 6.90%; for a sloped plane facing south, the losses are 5.39%, and for a sloped plane facing north, the losses are 6.86%. In comparison to the masking losses, the percentage of shading losses for the horizontal plane is 0.83%; for the sloped plane facing south, the losses are 0.42%, and for the sloped plane facing north, the losses are 1.37%.
Control Strategies for Daylight and Artificial Lighting in Office Buildings—A Bibliometrically Assisted Review
Authors: Plörer Daniel , Hammes Sascha , Hauer Martin , van Karsbergen Vincent , Pfluger Rainer
Published: June 2021

A significant proportion of the total energy consumption in office buildings is attributable to lighting. Enhancements in energy efficiency are currently achieved through strategies to reduce artificial lighting by intelligent daylight utilization. Control strategies in the field of daylighting and artificial lighting are mostly rule-based and focus either on comfort aspects or energy objectives. This paper aims to provide an overview of published scientific literature on enhanced control strategies, in which new control approaches are critically analysed regarding the fulfilment of energy efficiency targets and comfort criteria simultaneously. For this purpose, subject-specific review articles from the period between 2015 and 2020 and their research sources from as far back as 1978 are analysed. Results show clearly that building controls increasingly need to address multiple trades to achieve a maximum improvement in user comfort and energy efficiency. User acceptance can be highlighted as a decisive factor in achieving targeted system efficiencies, which are highly determined by the ability of active user interaction in the automatic control system. The future trend is moving towards decentralized control concepts including appropriate occupancy detection and space zoning. Simulation-based controls and learning systems are identified as appropriate methods that can play a decisive role in reducing building energy demand through integral control concepts.
A Review of Photovoltaic Thermal (PVT) Technology for Residential Applications: Performance Indicators, Progress, and Opportunities
Authors: Bandaru Sree Harsha , Becerra Victor , Khanna Sourav , Radulovic Jovana , Hutchinson David , Khusainov Rinat
Published: June 2021

Solar energy has been one of the accessible and affordable renewable energy technologies for the last few decades. Photovoltaics and solar thermal collectors are mature technologies to harness solar energy. However, the efficiency of photovoltaics decays at increased operating temperatures, and solar thermal collectors suffer from low exergy. Furthermore, along with several financial, structural, technical and socio-cultural barriers, the limited shadow-free space on building rooftops has significantly affected the adoption of solar energy. Thus, Photovoltaic Thermal (PVT) collectors that combine the advantages of photovoltaic cells and solar thermal collector into a single system have been developed. This study gives an extensive review of different PVT systems for residential applications, their performance indicators, progress, limitations and research opportunities. The literature review indicated that PVT systems used air, water, bi-fluids, nanofluids, refrigerants and phase-change material as the cooling medium and are sometimes integrated with heat pumps and seasonal energy storage. The overall efficiency of a PVT system reached up to 81% depending upon the system design and environmental conditions, and there is generally a trade-off between thermal and electrical efficiency. The review also highlights future research prospects in areas such as materials for PVT collector design, long-term reliability experiments, multi-objective design optimisation, techno-exergo-economics and photovoltaic recycling.
Identification of DC Thermal Steady-State Differential Inductance of Ferrite Power Inductors
Authors: Musumeci Salvatore , Solimene Luigi , Ragusa Carlo Stefano
Published: June 2021

In this paper, we propose a method for the identification of the differential inductance of saturable ferrite inductors adopted in DC–DC converters, considering the influence of the operating temperature. The inductor temperature rise is caused mainly by its losses, neglecting the heating contribution by the other components forming the converter layout. When the ohmic losses caused by the average current represent the principal portion of the inductor power losses, the steady-state temperature of the component can be related to the average current value. Under this assumption, usual for saturable inductors in DC–DC converters, the presented experimental setup and characterization method allow identifying a DC thermal steady-state differential inductance profile of a ferrite inductor. The curve is obtained from experimental measurements of the inductor voltage and current waveforms, at different average current values, that lead the component to operate from the linear region of the magnetization curve up to the saturation. The obtained inductance profile can be adopted to simulate the current waveform of a saturable inductor in a DC–DC converter, providing accurate results under a wide range of switching frequency, input voltage, duty cycle, and output current values.
Comparison of Screening Configurations for the Mitigation of Voltages and Currents Induced on Pipelines by HVAC Power Lines
Authors: Popoli Arturo , Sandrolini Leonardo , Cristofolini Andrea
Published: June 2021

In this paper, a strategy for reducing the electromagnetic interferences induced by power lines on metallic pipelines is proposed and numerically investigated. The study considers a set of steel conductors interposed between the power line and the pipeline. Different shapes of conductor cross sections and different magnetic permeabilities are considered, to identify the solution exhibiting the greatest mitigation efficiency for the same amount of material. The investigation is carried out by means of a quasi-3D finite element analysis. Results show that the main mechanism responsible for the mitigation is constituted by the currents induced in the screening conductors by the power line. Hence, a high magnetic permeability can have a detrimental effect since it reduces the skin depth to values below the size of the screening conductor. In this case, a reduction of the screening current and in the mitigation efficiency is observed. Nevertheless, the study shows that the use of strip-shaped screening conductors allows the employment of cheaper magnetic materials without compromising the mitigation efficacy of the screening conductors.
Bottled Biogas—An Opportunity for Clean Cooking in Ghana and Uganda
Authors: Black Mairi J. , Roy Amitava , Twinomunuji Edson , Kemausuor Francis , Oduro Richard , Leach Matthew , Sadhukhan Jhuma , Murphy Richard
Published: June 2021

Anaerobic digestion (AD) can bring benefits in terms of effective management of organic waste, recovery of nutrients and energy recovery, and is consistent with circular economy principles. AD has been promoted and implemented worldwide, but at widely differing scales, influenced by the availability and location of feedstocks. In developing countries, feedstock arises from small- to medium-scale agriculture and agro-processing operations, as well as from household and municipal waste. Biogas produced from residues from agro-processing facilities may be used for on-site heat and power, but the lack of a gas and electricity grid infrastructure can limit opportunities to distribute gas or generated electricity to wider users. This paper presents the findings of the first study to consider novel technologies for small-scale and low-cost biogas clean-up into biomethane, and compression into small bottles, suitable as a clean cooking fuel. The paper reports on the initial evaluation of biomethane for cooking in Ghana and Uganda.
Algorithm for Implementation of Optimal Vector Combinations in Model Predictive Current Control of Six-Phase Induction Machines
Authors: Romero Carlos , Delorme Larizza , Gonzalez Osvaldo , Ayala Magno , Rodas Jorge , Gregor Raul
Published: June 2021

The development of new control techniques for multiphase induction machines (IMs) has become a point of great interest to exploit the advantages of these machines compared to three-phase topology, for example, the reduced phase currents and lower harmonic contents. One of the most analyzed techniques is the model-based predictive current control (MPC) with a finite control set. This technique presents high x–y currents because of the application of one switching state throughout the whole sampling period. Nevertheless, it is one of the most used due to its excellent dynamic response. To overcome the aforementioned drawbacks, new techniques called virtual vectors have been developed, but although there are several articles with experimental results, the algorithm for implementing the technique has not been appropriately described. This document provides a clear and detailed explanation for algorithm implementation of virtual vectors through two proposed variants VV4 and VV11, in a six-phase machine drive. The first entails lower computational cost and the second lower loss in the x–y plane. According to performance indicators such as the total harmonic distortion and the mean square error for both case studies, experimental tests were evaluated to determine the implementation’s behaviour.
Heat Transmission of Engine-Oil-Based Rotating Nanofluids Flow with Influence of Partial Slip Condition: A Computational Model
Authors: Hussain Azad , Arshad Mubashar , Rehman Aysha , Hassan Ali , Elagan Sayed K. , Alshehri Nawal A.
Published: June 2021

This particular research was conducted with the aim of describing the impact of a rotating nanoliquid on an elasting surface. This specific study was carried out using a two-phase nanoliquid model. In this study engine oil is used as the base fluid, and two forms of nanoparticles are used, namely, titanium oxide and zinc oxide (TiO2 and ZnO). Using appropriate similarity transformations, the arising system of partial differential equations and the related boundary conditions are presented and then converted into a system of ordinary differential equations. These equations are numerically tackled using powerful techniques. Graphs for nanoparticle rotation parameter and volume fraction for both types of nanoparticles present the results for the velocity and heat transfer features. Quantities of physical significance are measured and evaluated, such as local heat flux intensity and local skin friction coefficients at the linear stretching surface. Numerical values for skin friction and local heat flux amplitude are determined in the presence of slip factor.
Pyrolysis of Solid Waste for Bio-Oil and Char Production in Refugees’ Camp: A Case Study
Authors: AlDayyat Ebtihal A. , Saidan Motasem N. , Al-Hamamre Zayed , Al-Addous Mohammad , Alkasrawi Malek
Published: June 2021

The current research focuses on assessing the potential of municipal solid waste (MSW) conversion into biofuel using pyrolysis process. The MSW samples were taken from Zaatari Syrian Refugee Camp. The physical and chemical characteristics of MSW were studied using proximate and elemental analysis. The results showed that moisture content of MSW is 32.3%, volatile matter (VM) is 67.99%, fixed carbon (FC) content is 5.46%, and ash content is 24.33%. The chemical analysis was conducted using CHNS analyzer and found that the percentage of elements contents: 46% Carbon (C) content, 12% Hydrogen (H2), 2% Nitrogen (N2), 44% Oxygen (O2), and higher heat value (HHV) is 26.14 MJ/kg. The MSW pyrolysis was conducted using tubular fluidized bed reactor (FBR) under inert gas (Nitrogen) at 500 °C with 20 °C/min heating rate and using average particles size 5–10 mm. The products of MSW pyrolysis reaction were: pyrolytic liquid, solid char, and gaseous mixture. The pyrolytic oil and residual char were analyzed using Elemental Analyzer and Fourier Transform Infrared Spectroscopy (FTIR). The results of FTIR showed that oil product has considerable amounts of alkenes, alkanes, and carbonyl groups due to high organic compounds contents in MSW. The elemental analysis results showed that oil product content consists of 55% C, 37% O2, and the HHV is 20.8 MJ/kg. The elemental analysis of biochar showed that biochar content consists of 47% C, 49% O2, and HHV is 11.5 MJ/kg. Further research is recommended to study the effects of parameters as reactor types and operating conditions to assess the feasibility of MSW pyrolysis, in addition to the environmental impact study which is necessary to identify and predict the relevant environmental effects of this process.
Different Techniques to Mitigate Partial Shading in Photovoltaic Panels
Authors: Alves Tiago , N. Torres João Paulo , Marques Lameirinhas Ricardo A. , F. Fernandes Carlos A.
Published: June 2021

The effect of partial shading in photovoltaic (PV) panels is one of the biggest problems regarding power losses in PV systems. When the irradiance pattern throughout a PV panel is inequal, some cells with the possibility of higher power production will produce less and start to deteriorate. The objective of this research work is to present, test and discuss different techniques to help mitigate partial shading in PV panels, observing and commenting the advantages and disadvantages for different PV technologies under different operating conditions. The motivation is to contribute with research, simulation, and experimental work. Several state-of-the-artsolutions to the problem will be presented: different topologies in the interconnection of the panels; different PV system architectures, and also introducing new solution hypotheses, such as different cell interconnections topologies. Alongside, benefits and limitations will be discussed. To obtain actual results, the simulation work was conducted by creating MATLAB/Simulink models for each different technique tested, all centered around the 1M5P PV cell model. The several techniques tested will also take into account different patterns and sizes of partial shading, different PV panel technologies, different values of source irradiation, and different PV array sizes. The results will be discussed and validated by experimental tests.
Spatiotemporal Patterns and Influencing Mechanism of Urban Residential Energy Consumption in China
Authors: Li Qiucheng , Hu Jiang , Yu Bolin
Published: June 2021

The residential sector has become the second largest energy consumer in China. Urban residential energy consumption (URE) in China is growing rapidly in the process of urbanization. This paper aims to reveal the spatiotemporal dynamic evolution and influencing mechanism of URE in China. The spatiotemporal heterogeneity of URE during 2007–2018 is explored through Kernel density estimation and inequality measures (i.e., Gini coefficient, Theil index, and mean logarithmic deviation). Then, with several advantages over traditional index decomposition analysis approaches, the Generalized Divisia Index Method (GDIM) decomposition is employed to investigate the impacts of eight driving factors on URE. Furthermore, the national and provincial decoupling relationships between URE and residential income increase are studied. It is found that different provinces’ URE present a significant agglomeration effect; the interprovincial inequality in URE increases and then decreases during the study period. The GDIM decomposition results indicate the income effect is the main positive factor driving URE. Besides, urban population, residential area, per capita energy use, and per unit area energy consumption positively influence URE. By contrast, per capita income, energy intensity, and residential density have negative effects on URE. There is evidence that only three decoupling states, i.e., weak decoupling, strong decoupling, and expansive negative decoupling, appear in China during 2007–2018. Specifically, weak decoupling is the dominant state among different regions. Finally, some suggestions are given to speed up the construction of energy-saving cities and promote the decoupling process of residential energy consumption in China. This paper fills some research gaps in urban residential energy research and is important for China’s policymakers.
Assessing the Flexibility of Renewable Energy Multinational Corporations
Authors: Prokazov Iurii , Gorbanyov Vladimir , Samusenkov Vadim , Razinkina Irina , Chłąd Monika
Published: June 2021

Currently, international business and society are on the eve of large-scale changes. The study aims to develop a methodological approach to assess the energy flexibility of multinational corporations in the context of the structural transformation management of renewable energy production. The methodology of this study is based on a comprehensive approach, which includes the methodology of the United States Agency for International Development (USAID), diagnostics of the level of development and energy flexibility of multinational corporations, regression analysis and scenario modeling. In particular, scenario analysis of renewable energy development in countries of the Commonwealth of Independent States (CIS) and economic analysis of projects for the development of corporate renewable energy industry were carried out. The results showed that the Russian renewable energy business is flexible enough for changes; however, at the same time, changes are needed in the national legislation, the basics of work, the national energy market; the conditions should be formed for the development of this business, a green tariff on a market basis should be formed, etc. The scientific contribution of this study is the proposed indicator in the form of the Multinational Corporation Energy Flexibility Index. It provides an opportunity to diagnose the agility of multinational corporations’ development, taking into account changes in their production structure. The developments obtained in the course of the work can be applied for studies related to assessing the flexibility of national energy systems, as well as in the practice of managing multinational corporations operating in the field of renewable energy.
Investigating the Shielding Effect of Pulse Transformer Operation in Isolated Gate Drivers for SiC MOSFETs
Authors: Makki Loreine , Mannah Marc Anthony , Batard Christophe , Ginot Nicolas , Weckbrodt Julien
Published: June 2021

Wide-bandgap technology evolution compels the advancement of efficient pulse-width gate-driver devices. Integrated enhanced gate-driver planar transformers are a source of electromagnetic disturbances due to inter-winding capacitances, which serve as a route to common-mode (CM) currents. This paper will simulate, via ANSYS Q3D Extractor, the unforeseen parasitic effects of a pulse planar transformer integrated in a SiC MOSFET gate-driver card. Moreover, the pulse transformer will be ameliorated by adding distinctive shielding layers aiming to suppress CM noise effects and endure high dv/dt occurrences intending to validate experimental tests. The correlation between stray capacitance and dv/dt immunity results after shielding insertion will be reported.
An RTDS-Based Testbed for Investigating the Impacts of Transmission-Level Disturbances on Solar PV Operation
Authors: Maharjan Manisha , Ekic Almir , Strombeck Bennett , Wu Di
Published: June 2021

The increasing penetration of renewable energy resources such as solar and wind via power electronic inverters is challenging grid dynamics, as well as grid planning, operation, and protection. Recently, the North American Electric Reliability Corporation (NERC) has reported a series of similar events of the unintended loss of solar generation in Southern California over a large geographic area following the transmission-level disturbances. These events highlight the importance of understanding the characteristics of the transmission-side disturbances propagating into the distribution systems and their impacts on the operation of inverter-based resources. In this paper, a real-time electromagnetic simulation testbed is constructed for real-time electromagnetic simulations to generate realistic transmission-level disturbances and investigate their impacts on the solar PV operation under different fault types and locations, solar penetration levels, and loading levels. Through the simulation analysis and grid strength assessment, it is found that the grid strength at points of integration (POIs) of solar PVs significantly affects the transient stability of solar generators. Particularly, undesirable transient stability events are more likely to occur at the weak POIs following the transmission-level disturbances. Moreover, undesirable transient stability events become severer when the transmission-level disturbance is closer to the weak POIs or the disturbances become more serious. Additionally, the impact of the transmission-level disturbances on the solar PVs at the weak POIs exacerbate with the increasing solar penetration levels and loading levels. Thus, it is important to study and develop new technologies for grid planning, operation, and protection in weak grid conditions to address the emerging issues of integrating the high penetration of solar PVs and other IBRs.
Simulation of the Part Load Behavior of Combined Heat Pump-Organic Rankine Cycle Systems
Authors: Eppinger Bernd , Muradi Mustafa , Scharrer Daniel , Zigan Lars , Bazan Peter , German Reinhard , Will Stefan
Published: June 2021

Pumped Thermal Energy Storages (PTES) are suitable for bridging temporary energy shortages, which may occur due to the utilization of renewable energy sources. A combined heat pump (HP)-Organic Rankine Cycle (ORC) system with suitable thermal storage offers a favorable way to store energy for small to medium sized applications. To address the aspect of flexibility, the part load behavior of a combined HP-ORC system, both having R1233zd(E) (Trans-1-chloro-3,3,3-trifluoropropene) as working fluid and being connected through a water filled sensible thermal energy storage, is investigated using a MATLAB code with integration of the fluid database REFPROP. The influence on the isentropic efficiency of the working machines and therefore the power to power efficiency (P2P) of the complete system is shown by variation of the mass flow and a temperature drop in the thermal storage. Further machine-specific parameters such as volumetric efficiency and internal leakage efficiency are also considered. The results show the performance characteristics of the PTES as a function of the load. While the drop in storage temperature has only slight effects on the P2P efficiency, the reduction in mass flow contributes to the biggest decrease in the efficiency. Furthermore, a simulation for dynamic load analysis of a small energy grid in a settlement is conducted to show the course of energy demand, supplied energy by photovoltaic (PV) systems, as well as the PTES performance indicators throughout an entire year. It is shown that the use of PTES is particularly useful in the period between winter and summer time, when demand and supplied photovoltaic energy are approximately equal.