bluuebunny/crossref_metadata_2025 huggingface dataset:
Supraventricular tachycardia and ventricular septal ablation in hypertrophic obstructive cardiomyopathy: a case report
Authors: Xing Xueqin , Guo Yanqing , Bai Yinlong , Wang Wei , Qiu Yingru , Wang Yikai , Li Peng , Ma Yueteng , Duan Yunxia
Published: March 2022

A case of hypertrophic obstructive cardiomyopathy complicated with
paroxysmal supraventricular tachycardia is reported in this paper. The
main clinical manifestations of the patient were shortness of breath
after activity, palpitation that appeared gradually and transient
amaurosis. There was no significant relief of symptoms after the
application of β- blocker and other drugs, and color doppler
echocardiography indicated that the pressure difference of left
ventricular outflow tract increased gradually. The patient was treated
with supraventricular tachycardia radiofrequency ablation combined with
ventricular septal radiofrequency ablation under the guidance of
intracardiac ultrasound.The symptoms of palpitation, shortness of breath
and amaurosis disappeared, and the quality of life and exercise
endurance of the patient were significantly improved when the first
follow-up at 1 month was performed after the operation. The purpose of
this case is to provide ideas for the end point, energy selection and
prognosis criteria of ventricular septal ablation for hypertrophic
obstructive cardiomyopathy by analyzing the clinical and surgical data
of the patient.
Assessment of hepatitis B surface antibody in children after allogeneic peripheral blood stem cell transplantation and impact of donor/recipient immunity on hepatitis B surface antibody disappearance
Authors: Yuan Qing , Zhou Fen , Zhang Hua , Wang Jian , Zhang An , Cao Qing , Chen Wen , Fei YI , Luo Chang , Gao Yi
Published: March 2022

After allogeneic peripheral blood stem cell transplantation (PBSCT),
children are at high risk of hepatitis B virus (HBV) infection because
of the potential loss of HBV immunity. The factors which can affect it
are not fully understand. This study aimed to assess the probability of
hepatitis B surface antibody (HBsAb) disappearance after PBSCT and to
evaluate the impact of donor and recipient immunity on HBsAb
disappearance. A total of 110 patients who underwent PBSCT between
January 2016 and December 2018 and their paired donors were
retrospectively enrolled in this study. Before transplantation, 87
(79.1%) patients were HBsAb seropositive, and 23 (20.9%) were HBsAb
seronegative. Fifty-five (63.2%) patients with protective HBsAb titers
before PBSCT lost their HBV immunity within one year after
transplantation. Univariate analysis showed that the low recipient
pretransplant HBsAb titer, antithymocyte globulin (ATG) administration,
corticosteroid administration and graft-versus-host disease (GVHD) were
significant risk factors for HBsAb disappearance (P<0.05).
Multivariate analysis showed that only recipient pretransplant HBsAb
titers lower than 207.5 IU/L (P=0.022, hazard ratio (HR): 1.925, 95%
confidence interval (CI): 1.101-3.367) and the presence of GVHD
(P=0.033, HR=1.921, 95% CI: 1.056-3.495) were risk factors for HBsAb
disappearance one year after HSCT. In conclusion, most recipients lost
previously acquired immunity to HBV after PBSCT. A high titer of HBsAb
in the recipient before transplantation had a protective effect against
posttransplant HBsAb disappearance, but the presence of donor immunity
did not significantly influence the maintenance of recipient immunity to
HBV.
T Lymphoblastic Lymphoma with BCR-ABL Negative Chronic Myeloid Leukaemia …a Novel Association
Authors: Faizan Mahwish , Anwar Saadia , Ain Rahat Ul , Zafar Huma , Saqlain Nazish , Rathore Zunaira
Published: March 2022

Lymphoblastic Lymphoma and Chronic Myeloid leukemia are two distinct
neoplasms with different pathogenesis and clinical presentation. We
hereby share a challenging case of a child presenting with fever,
leucocytosis, generalized lymphadenopathy and massive splenomegaly. He
was diagnosed as having novel association of concurrent T-Lymphoblastic
Lymphoma diagnosed on cervical lymph node biopsy with BCR-ABL Negative
Chronic Myeloid leukemia on bone marrow aspirate. Study of more such
cases is needed for optimal patient management.
Neurological Impact of Corona virus disease 2019 (COVID-19) infection
Authors: Shayeb Mohamed El , Eid Yara , Sheha Dina , Amin mariam , Saeed Aliaa , Abdou Dina , Aly Tarek , AboElyazed Sherihan , Samy Sherief , Elziaty Rahma , Sheha Aliaa , Osman Ahmed
Published: March 2022

Great concerns over the influence of corona virus disease 2019
(COVID-19) on the nervous system have been growing since the first
reported case of neurological affection in China. Neurologic
presentations of COVID-19 are variable and may occur prior to the
diagnosis. These can present variably in the disease course and were
found to have more severe disease courses. We report two case of
COVID-19 with different neurological presentations. The burden of
COVID-19 and its neurological manifestations necessitate the urgent
recognition of these neurological conditions for treating such patients.
A Comparison of Outpatient Treatment of Three Medical Groups with Fetal Death in the First Trimester of Pregnancy during the COVID-19 Pandemic: A Randomized, Controlled, Double-Blind Clinical Trial
Authors: Jahromi Athar Rasekh , Shahriarirad Reza , Masoudi Ali , babaarabi Zahra Zarei , Taghipour Nikta
Published: March 2022

Objective: To evaluate the efficacy and side effects of each medication
regime, a comparison was drawn between the administration of misoprostol
with the combined use of misoprostol plus oxytocin and misoprostol plus
methylergometrine for full expulsion of retained intrauterine tissues in
patients who underwent a miscarriage. Design: randomized, double-blind,
clinical trial Setting: gynecology and obstetrics clinic in Jahrom,
Southern Iran Population: 90 patients with gestational age below 12
weeks and having undergone a recent miscarriage. Methods: They were
randomly allocated into three groups after being screened for underlying
diseases and coagulative blood disorders. For the first group, labeled
as the control group, misoprostol was administered alone, while as, the
combination of misoprostol plus methylergometrine and misoprostol plus
oxytocin was prescribed for the second and third groups, respectively.
Main Outcome Measures: Primary: Expulsion of retained products of
conception; Secondary: Pain, Hemorrhage Results: Despite no significant
statistical difference being observed in the expulsion of retained
products of conception (RPOC)by the administration of misoprostol alone
or with combined medical therapy of misoprostol with oxytocin or
methylergometrine (P-value< 0.329), all of them showed a
successful treatment. Additionally, the patients treated with
misoprostol and oxytocin showed good results in expelling the
RPOC(P=0.013); while as, those treated by misoprostol plus
methylergometrine reported controlled pain and hemorrhage after an
abortion (P=0.004). Conclusion: The course of medications viz.
methylergometrine, oxytocin, and misoprostol indicated a successful
outpatient treatment in patients that had experienced a miscarriage or
an incomplete abortion. They are cost-effective and have shown lesser
side effects.
Bi*-topological space
Authors: Abbas fadhil
Published: March 2022

In this paper, we introduce a new class of Bi-topological space called
Bi*-topological space. Also, introduce and study Bi*-topological
properties of bi∗-open (bi∗∗-open) sets and bi∗-closed (bi∗∗-closed)
sets, etc. Moreover, introduce and study some type of sets in
Bi∗-topological space and also some type of continuous functions in
Bi∗-topological space
Association of metformin with the mortality and incidence of cardiovascular events in patients with pre-existing cardiovascular diseases
Authors: Li Tian , Providencia Rui , Jiang Wenhua , Mu Nan , Wang Yishi , Li Xiaokang , Yin Yue , Liu Manling , Yu Lu , Gu Chunhu , Chang Alex Chia Yu , Ma Heng
Published: March 2022

Background and Purpose Whereas whether metformin reduce all-cause,
cardiovascular mortality, and incidence of cardiovascular events in
patients with cardiac diseases remains inconclusive. Experimental
Approach PubMed and Embase were searched up to May 2020 with a
registration in PROSPERO (CRD42020189905) were collected. This article
includes randomized controlled trials (RCT) and cohort studies. Hazard
ratio (HR) with 95% CI was pooled across various trials by a
random-effects model. Risk of bias was accounted as per Cochrane and
Newcastle-Ottawa Scale (NOS) guidelines. Key Results This article
enrolled 48 articles (1999-2020) for qualitative synthesis and
identified 26 articles (33 studies in total, 61,704 patients) for final
quantitative synthesis. Compared with non-metformin control, metformin
is associated with reduced all-cause mortality (HR: 0.90; 95% CI: 0.83,
0.98; P = 0.01), cardiovascular mortality (HR: 0.89; 95% CI: 0.85,
0.94; P < 0.0001), incidence of coronary revascularization
(HR: 0.79; 95% CI: 0.64, 0.98; P = 0.03), and heart failure (HR: 0.90;
95% CI: 0.87, 0.94; P < 0.0001) in patients with cardiac
diseases, whereas metformin is not associated with reduced incidence of
myocardial infarction (HR: 0.97; 95% CI: 0.80, 1.17; P = 0.73), angina
(HR: 0.29; 95% CI: 0.04, 2.35; P = 0.25), and stroke (HR: 0.95; 95%
CI: 0.78, 1.16; P = 0.59). Conclusion and Implications Metformin reduces
all-cause mortality, cardiovascular mortality, incidence of coronary
revascularization, and heart failure of patients with cardiac diseases,
whereas metformin is not associated with reduced incidence of myocardial
infarction, angina, and stroke.
The Effects of L-shaped Heat Source in a Quarter-tube Enclosure Filled with MHD Nanofluid on Heat Transfer and Irreversibilities, using LBM: Numerical data, Optimization Using Neural Network Algorithm (ANN)
Authors: Ibrahim Muhammad , Saeed Tareq , Algehyne Ebrahem A. , Khan Majid , Chu Yu-Ming
Published: March 2022

In this paper, the process of natural convection heat transfer (NCHT)
and production of entropy (POF) in a portion of a tube has been modeled
two-dimensionally. The examined problem is a quarter-tubular enclosure
(quarter of a tube) which is filled with water-alumina nanofluid and
subjected to a magnetic field (MF) of strength B0 at angle relative to
horizon. Lattice Boltzmann Method (LBM) is used to simulate this
problem. The ranges of parameters used in this investigation are: 0
< ω < 90, 0 < Ha < 60, and 0.1
< L, H < 0.5, and the obtained results include the
Nusselt number (Nu), generated entropy, and Bejan number (Be). The
results of thermal and dynamic analyses indicate that by growing the
Hartmann number (Ha), the NCHT and POF values go up and the
Bediminishes. Heat transfer is also improved by increasing the length of
the enclosure’s hot walls. The highest amount of heat transfer occurs at
the MF angle of 60º, and it is 10.3% greater than the amount of heat
transfer occurring at horizontal MF. Finally, an artificial neural
network (ANN) was used to simulate the cavity performance based on these
parameters. An optimization is performed on the parameters of heat
source length and Ha. The optimization is aimed at finding suitable
parameter values that lead to the highest heat transfer rate and lowest
POF. A table listing a number of optimal points has been presented at
the end of the paper.
Predictors of in-hospital mortality in patients admitted to the emergency department with cardiogenic pulmonary edema
Authors: sert ekrem taha , Kokulu Kamil , Gul Murat , mutlu huseyin
Published: March 2022

Background: Despite significant advances in the treatment of heart
failure, the prognosis of acute cardiogenic pulmonary edema (ACPE)
continues to be a serious problem. The objective of this study is to
determine the risk factors affecting in-hospital mortality in patients
with ACPE. Methods: We enrolled 305 patients who were hospitalized with
cardiogenic pulmonary edema as a diagnosis. Clinical, biochemical and
echocardiographic variables were collected and analysed. The patients
were divided into two groups according to the presence of mortality.
Both groups were evaluated in terms of clinical features during
admission to the emergency department (ED) and factors affecting
in-hospital mortality. Results: Forty-two patients died and the
mortality rate was 13.8%. To determine the factors affecting mortality,
multiple logistic regression analysis was performed. In the regression
analysis, it was seen that age at admission to the ED (OR:1.75, 95% CI
1.18-3.05, p:0.014), systolic blood pressure (OR:0.95, 95% CI
0.31-0.98, p:0.040), presence of acute myocardial infarction (OR:4.17,
95% CI 1.85-7.13, p:0.001), positive troponin (OR:5.47, 95% Cl
1.07-7.46, p:0.011), atrial fibrillation rhythm (OR;3.16, 95% CI
1.81-8.02, p:0.010), inotropic drug usage (OR;5.61, 95% CI 1.87-9.24,
p:0.013) increased in-hospital mortality. Conclusion: Our findings might
help clinicians in identifying patients with poor prognosis early in the
presence of identified risk factors.
Acute coronary syndrome as initial presentation of polycythaemia Vera
Authors: alfar hadeel , yassin mohamed
Published: March 2022

Polycythaemia Vera is one of Myeloproliferative neoplasm which has
common and uncommon mode of presentations. Myocardial infarction is one
of uncommon presentations.we report a55year old women presented with
myocardial infarction and found to have polycythemia vera treated with
cytoreduction in form of Hydroxyurea 500 mg twice daily with favourable
outcome
A systematic review and meta-analysis on the safety and efficacy of tocilizumab in the management of COVID-19
Authors: Viswanatha Gollapalle Lakshminarayanashatry , Male CH K V L S N Anjana , Shylaja Hanumanthappa
Published: March 2022

Objective: This systematic review and meta-analysis was aimed to
evaluate the therapeutic benefits and safety of tocilizumab (TCZ) in
treating severe coronavirus disease 2019 (COVID-19) and associated
health complications. Methods: The electronic search was performed using
PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials
(RCTs) and Google scholar databases to identify the randomized control
trials. Mortality, incidences of ICU admission, need of mechanical
ventilation (MV), length of stay in the hospital (LOS) and length of
stay in the ICU (LOS-ICU) and the incidences of super-infection,
bacteraemia, fugleman, pneumonia and pulmonary thrombosis were evaluated
as the primary outcomes. The comparison will be between TCZ versus
standard of care (SOC)/placebo. Results: Based on the inclusion criteria
there were 24 retrospective studies involving 5686 subjects were
included. The outcomes of the meta-analysis have revealed that the TCZ
has reduced the mortality (Mantel-Haenszel (M-H), random effects risk
difference (RE-RD) of -0.11 (-0.18 to -0.04), at 95% CI, p = 0.001, I2
= 88%) and increased the incidences of super-infections (M-H, RE-Risk
ratio (RR) of 1.49 (1.13 to 1.96) at 95% CI, p=0.004, I2 = 47%).
However, there is no significant difference in ICU admissions rate, need
of MV, LOS, LOS-ICU, and incidences of pulmonary thrombosis compared to
SOC/control. Conclusion: Based on the outcomes of the meta-analysis we
can conclude that administration of TCZ would reduce the risk of
mortality, and however there is no much difference observed between the
TCZ and SOC/control groups in other parameters.
Optical solitons of the (2+1)-dimensional Kundu-Mukherjee-Naskar equation with Lokal M-derivative
Authors: Bekir Ahmet , Raza Nauman , Rezazadeh Hadi , Rafiq Muhammad Hamza
Published: March 2022

This paper aims to uncover fairly interesting optical soliton solutions
in (2+1)-dimensions. The fractional temporal Kundu-Mukherjee-Naskar
(KMN) equation is reviewed as a governing model. Local M-derivative
along with the unified approach is used to acquire these soliton
solutions. The predicted solutions are yielded with the constraint
conditions and highlighted by their graphical portrayal. Lastly, the
inuence of a local fractional parameter upon predicted solutions are
depicted through 2D and 3D graphs.
Genome-scale data reveal deep lineage divergence and a complex demographic history in the Texas horned lizard (Phrynosoma cornutum) throughout the southwestern and central US
Authors: Finger Nicholas , Farleigh Keaka , Bracken Jason , Leaché Adam , François Olivier , Yang Ziheng , Flouri Tomas , Charran Tristan , Jezkova Tereza , Williams Dean , Blair Christopher
Published: March 2022

The southern US and northern Mexico serve as an ideal region to test
alternative hypotheses regarding biotic diversification. Genomic data
can now be combined with sophisticated computational models to quantify
the impacts of paleoclimate change, geographic features, and habitat
heterogeneity on spatial patterns of genetic diversity. In this study we
combine thousands of genotyping-by-sequencing (GBS) loci with mtDNA
sequences (ND1) from the Texas Horned Lizard (Phrynosoma cornutum) to
quantify relative support for different catalysts of diversification.
Phylogenetic and clustering analyses of the GBS data indicate support
for at least three primary populations with evidence of recent
admixture. The spatial distribution of populations appears concordant
with habitat type, with desert populations in Arizona and New Mexico
showing the largest genetic divergence. The mtDNA data also support a
divergent desert population, but other relationships differ and suggest
mtDNA introgression. Genotype-environmental association analyses support
divergence along environmental axes. Demographic analyses support a
model of allopatric divergence during the Pleistocene followed by
secondary contact and gene flow. These results are consistent with
inferred paleo-species distribution models. Our results also indicate
that caution is warranted when fitting a multispecies coalescent model
without introgression to populations that have exchanged genes
throughout their diversification history. In sum, our results support
allopatric divergence due to Pleistocene climate change, which was
followed by secondary contact and widespread genomic introgression.
Results also suggest that populations are continuing to diverge along
habitat gradients. Finally, the strong evidence of admixture, gene flow,
and mtDNA introgression among populations suggests that P. cornutum
should be considered a single widespread species.
Current practices, attitudes and demands of Chinese anesthesiologists regarding depth of anesthesia monitoring
Authors: Zhan Jian , Yi Ting-Ting , Wu Zhuo-Xi , Long Zong-Hong , Bao Xiao-Hang , Xiao Xu-Dong , Du Zhi-Yong , Wang Ming-Jun , Li Hong
Published: March 2022

Rationale, aims and objectives: To determine current practices,
attitudes and demands of Chinese anesthesiologists regarding depth of
anesthesia (DoA) monitoring. Method: An anonymous online survey was
randomly distributed to 8,556 anesthesiologists. Results: The overall
response rate was 47% (4,037 respondents). Only 9.1% (95% confidence
interval, 8.2%-10.0%) of the respondents routinely use DoA monitors.
The main factors influencing the utility of DoA monitors were poor
anti-interference ability (56.0%, 54.5%-57.6%), inability to bill
insurance or high cost (55.5%, 54.0%-57.0%), limited accuracy
(47.9%, 46.3%-49.4%) and inability to monitor analgesic effects
(35.7%, 34.2%-37.1%). Academic respondents (91.5%, 90.3%-92.7%)
primarily used DoA monitoring to prevent awareness, whereas nonacademic
respondents (88.8%, 87.4%-90.2%) primarily used DoA monitoring to
guide the delivery of anesthetics. In total, the respondents who had not
used a DoA monitor and experienced awareness (61.7%, 57.8%-65.6%) was
significantly greater than those who had used one or several DoA
monitors (51.5%, 49.8%-53.2%). However, most respondents (95.7%,
95.1%-96.3%) demanded improvements in the accuracy of the monitors for
DoA monitoring and a broad application in patients of all ages (86.3%,
85.2%-87.4%), analgesia monitoring (80.4%, 79.2%-81.6%) and all
types of anesthetics (75.6%, 74.3%-76.9%). In total, 65.0%
(63.6%-66.5%) of the respondents believed that DoA monitors should be
combined with EEG and vital sign monitoring, and 53.7% (52.1%-55.2%)
believed that advanced DoA monitors should include artificial
intelligence. Conclusions: Academic anesthesiologists primarily use DoA
monitoring to help prevent awareness, whereas nonacademic
anesthesiologists use DoA monitoring to guide the delivery of
anesthetics. Regardless of whether a DoA monitor is used,
anesthesiologists believe that DoA monitoring could help to reduce the
incidence of awareness. Anesthesiologists demand high-accuracy DoA
monitors incorporating signals of EEG, multiple vital signs and
antinociceptive indicators. DoA monitors with artificial intelligence
may represent a new direction for future research on DoA monitoring.
Use of del Nido Cardioplegia Solution in Adult Aortic Surgery
Authors: Eris Cuneyt , engin mesut , erdolu burak , AS AHMET
Published: March 2022

Background:The aim of the present study was to compare the operative and
early postoperative results of the use of del Nido Cardioplegia
solution(dNCS) with traditional blood cardioplegia(BC) in adult aortic
surgery. Methods: A retrospective single-center study was performed on
118 patients who underwent aortic surgery with cardiopulmonary bypass
(CPB) between January 2016 and June 2020. Patients were divided in to
two groups according to the type of cardioplegia solution used during
the operation. Cardiac arrest was achieved in Group 1(n:65) with
traditional BC and in Group 2(n=53) with dNCS. Operative and
postoperative outcomes of the patients were compared between the two
groups. Results: Patient demographic characteristics were similar
between the two groups. dNCS group showed significantly lower aortic
cross-clamp (ACC) time(87,5 vs 73,3 min; P=0.001), cardioplegia volume
(P<0.001), defibril¬lation(P=0.006), drenaige amount(P=0.026)
and inotropic support need (P=0.046).Also dNCS group had significantly
lower high sensitive troponin I (hsTnI) values at 6th
(P=<0.001) and 24th (P=0.017) hours. Hematocrit levels at
hours 6 and 24 were significantly higher in dNCS (P=0.001).Time of
intensive care unit stay, duration of extubation and length of hospital
stay times were similar in both groups. There was no significant
difference in terms of postoperative ejection fraction values(P=0.714).
Conclusion: Compared with conventional BC, dNCS provided beter
myocardial protection with significantly shorter ACC times, reduced need
for intraoperative defibrillation, postoperative lower hsTnI levels and
comparable early clinical outcomes for adult patients undergoing aortic
surgery. dNCS is a safe and efficient alternative to the traditional BC
solution in adult cardiac surgery.
Characterization of the major allergen, Que ac 1, from sawtooth oak pollen
Authors: Jeong Kyoung Yong , Lee Jong Sun , Yuk Ji Eun , Park Jong Han , Ferreira-Briza Fatima , Sang Min Kyu , Lee Yong Seok , Vogel Lothar , Park Kyung Hee , Park Jung-Won
Published: March 2022

Background: Sawtooth oak is a potent cause of tree pollinosis in Korea.
However, molecular characteristics of the major allergen have not been
elucidated. Objective: The study was to perform biochemical and
allergenic characterization from sawtooth oak. Methods: Native Que ac 1
was purified and analyzed by 2D gel electrophoresis and LC-coupled
ESI-MS/MS analysis. Polymorphisms of Que ac 1 were examined by RT-PCR,
and a recombinant allergen of the major isoform was produced. IgE
reactivities of the native and recombinant allergens were compared by
ELISA. Results: At least 12 isoforms of Que ac 1 were identified by
proteomic analysis, and 22 isoforms including two isoallergens were
identified by RT-PCR. A major isoform Que ac 1.0101 (13.3%, 10/75)
shared the lowest homology to Bet v 1 (58.1%) and the highest homology
to Que r 1 (83.0%). Recombinant Que ac 1.0101, which exhibited a
similar CD spectrum with native Que ac 1, was recognized by serum IgE
from 91.3% of Korean oak pollinosis patients. Recombinant Que ac 1
inhibited 67.2% of IgE reactivity to sawtooth pollen extract, but
native Que ac 1 and recombinant Bet v 1 inhibited 88.7% and 57.6% of
the IgE reactivity, respectively. No difference in allergen potential
was shown between Que ac 1 and Bet v 1 by basophil mediator release
assay. Conclusion: Molecular properties of the major allergen Que ac 1
were characterized. Que ac 1 seems to be an allergen of regional
importance homologous to Bet v 1 and may be useful for better
diagnostics of pollinosis.
“COMPARISON OF CLINICAL EFFICACY OF ROPIVACAINE AND LIGNOCAINE WITH ADRENALINE FOR IMPLANT SURGERY ANAESTHESIA- A SPLIT MOUTH RCT ” Data openly available
Authors: K REMYA , K Rithesh , GOPINATH SHARIKA
Published: March 2022

INTRODUCTION: The primary indications for utilization of long acting
local anesthetics in dentistry: lengthy dental procedures for which
pulpal anesthesia in excess of 90 minutes is necessary and management of
postoperative pain. Ropivacaine is a local anesthetic of the amide type
that chemically is homologous to bupivacaine and mepivacaine. It is
available in various concentrations and is said to have inherent
vasoconstrictive properties at low concentrations. The aim of the study
was to evaluate and compare the clinical efficacy of ropivacaine to
lignocaine for implant surgery anaesthesia. To assess the onset and
duration of anaesthesia the intraoperative and post-operative pain with
both local anaesthetics and the post-operative analgesics requirement.
MATERIALS AND METHODS:- 15 healthy subject with bilateral missing teeth
indicated for implant placement with age range of 20 -60 years,
reporting to the Department of Implantology, Rajarajeswari Dental
College and Hospital, Bangalore were selected for the study. The test
group involves implant surgeries in which ropivacaine was used. The
control group involves implant surgeries in which lignocaine with
adrenaline were used. RESULTS -The results were statistically analysed.
There was a statistically significant higher duration of anesthesia for
the test group as compared to the control group. Ropivacaine was found
to be superior to lignocaine as far as quality of anesthesia was
concerned. The comparison of mean VAS scores showed that ropivacaine has
better anesthetic and analgesic effect when compared to the control
group. CONCLUSION: Ropivacaine 0.75% provides significantly longer
duration of anesthesia than lignocaine 2% with adrenaline.
Transcriptional illustration of environmental effects on the cuticular hydrocarbon plasticity in three rice planthopper species
Authors: Li Dan-Ting , Pei Xiao-Jin , Ye Yu-Xuan , Wang Xin-Qiu , Wang Zhe-Chao , Chen Nan , Liu Tong-Xian , Fan Yong-Liang , Zhang Chuan-Xi
Published: March 2022

Insect cuticular hydrocarbons (CHCs) are the main components of the
surface lipid layer that function as a barrier against water loss and
xenobiotics penetration, and serve as chemical signals. Plasticity of
CHC profiles can vary depending upon numerous biological and
environmental factors. Understanding these factors associated with
variation in CHC profiles is important for identifying potential
vulnerabilities relating to pest ecology and developing novel pest
management strategies. In this study, we investigated potential sources
of variation in CHC profiles of Nilaparvata lugens, Laodelphax
striatellus and Sogatella furcifera which are important rice pests in
Asia. We quantified CHC profiles among three planthoppers by GC/MS, and
explored factors associated with variation in CHC profiles by using
principal component analysis (PCA). We further compared the
transcriptomes of the planthoppers under different environmental
conditions. The results showed that there were significant differences
in CHC profiles among the three species. CHC profiles can change with
different developmental stage, sex, temperature, humidity and host
plant. Genes involving in cuticular lipid biosynthesis pathway are
modulated, which might explain why CHC profiles are varying among
species; other differentially expressed genes related with amino acid
metabolism, cuticle proteins and heat shock proteins might also play
roles in regulating lipid metabolism of planthoppers for adapting to
different environments. Our study illustrates some of the biological and
ecological variations in modifying CHC profiles and the underlying
molecular regulation mechanisms of the planthoppers in coping with
changes of environmental conditions, and serves to better understanding
of molecular ecology regarding with CHCs plasticity.
Assuming stationarity compromises understanding of the dynamics and management of open marine populations
Authors: Chen Carla , Caley M. Julian
Published: March 2022

Understanding connectivity of marine species is crucial for their
management. This connectivity, however, is difficult to quantify;
propagules of marine species are typically small, numerous, and can
travel large distances. Consequently, oceanographic models are often
used to simulate larval dispersal. To avoid high computational costs,
these models typically use, pooled or cross-sectional data and fixed
biological parameters. Here we explore how temporal and spatial
variation in current velocities, and pelagic larval duration and
buoyancy can alter patterns of marine connectivity of Crown-of-Thorns
starfish on Australia’s Great Barrier Reef. Our results reveal highly
variable reef connectivity in space and time mediated by all three
factors. No individual reef acted consistently as a population source or
sink. It is, therefore, important to consider many factors concurrently
when estimating connectivity for understanding these population
dynamics, especially where such estimates are relied on for
evidence-based decision making.
Gestational weight gain ranges and maternal-infant adverse outcomes among Chinese women with gestation diabetes: a retrospective study
Authors: Zheng Qing-Xiang , Jiang Xiumin , Lin Yan , Liu Gui-Hua , Pan Mian , Ge Li , Chen Xiao-Qian , Wu Jing-Lin , Zhang Xiao-Yun , Pan Yu-Qing , HE Hong
Published: March 2022

Objective To identify the ranges of gestational weight gain for Chinese
women with gestational diabetes based on the different pre-pregnancy
body mass index group, and to investigate the association between
gestational weight gain and maternal-infant adverse outcomes. Design A
single-center retrospective cohort study. Setting A tertiary public
women’s and children’s hospital in China. Population Women with
gestational diabetes. Methods Retrospective analysis of 17,216 women
with gestational diabetes who delivered singleton, registered between
2013 and 2018. Main outcome measures Gestational weight gain ranges,
maternal-infant adverse outcomes. Results A total of 14,517 women were
included finally. In comparison to the recommended gestational weight
gain ranges by the National Academy of Medicine, the Chinese women with
gestational diabetes in this study had a wider weight gain ranges, and
faster rate of gestational weight gain. The risk of adverse outcomes
increased steadily with gestational weight gain in the four body mass
index groups. The ranges of gestational weight gain that were associated
with lower risks of maternal-infant adverse outcomes were 15-20kg,
14-18kg, 4-8kg, and 0-4kg for the underweight, normal weight, overweight
and obese groups, respectively. Conclusions The findings from this study
can be used as a guideline for Chinese women with gestational diabetes.
Healthcare professionals should provide targeted advice to women based
on their pre-pregnancy body mass index to reduce the risks of
maternal-infant adverse outcomes. Future high-quality and multi-center
prospective studies are needed to validate our findings. Keywords
Gestational weight gain, body mass index, gestational diabetes mellitus,
maternal-infant adverse outcomes
On rapidly varying sequences
Authors: Timotic Valentina , Djurcic Dragan , Kocinac Ljubisa
Published: March 2022

In this paper we investigate certain connections between the class Rs,? of
rapidly varying sequences (in the sense of de Haan) and the rapid
equivalence, selection principles and game theory.
From deliberation to participation: Democratic commitments and the paradox of voting
Authors: Soc Andrija
Published: March 2022

In this paper, I examine the view that, surprisingly, the more citizens
deliberate about politics, the less likely they are to participate in the
realm of the political, and vice versa. In the first part of the paper, I
approach the problem from the perspective of the paradox of voting, the
claim that voting itself is instrumentally irrational because of the very
low probability that a single vote will make any difference at the
elections. In the second part of the paper, I argue that rather than
analyzing voting instrumentally, it is better to view it as part of the
civic commitments that constitute what it means to be a citizen in a
democratic society. The act of voting is not primarily an individual?s
attempt to decisively influence any particular outcome, but an affirmation
of the key practice that upholds the democratic society in which citizens
play a part. This reveals a meta-paradox of voting. Namely, to not vote is
to exhibit a type of behavior that implies acceptance of democracy
simultaneously with rejecting its defining component. Because of that, I
will claim, not voting is itself irrational. In light of that conclusion, in
the third part of the paper, I explore the extant divide between
deliberation and participation by referring back to the analysis of civic
commitments. Whereas participation without deliberating reveals ideological
bias, deliberation without participation expresses a lack of understanding
of what it means to be a citizen. The way to connect them is to engage in a
process of attaining reflective equilibrium between the two, starting from
the practice of deliberation that would be fully informed by the awareness
of our democratic commitments and disconnected from ideologically motivated
participation.
ESTILOS DE APRENDIZAGEM: UMA ANÁLISE A PARTIR DA PROPOSTA DE KOLB
Authors: Araújo Cardoso Laiane , Silva Macedo Quitéria Laís , Gomes Damascena Vitória , Brandão Menezes Daniel
Published: March 2022

A aquisição do conhecimento se relaciona intrinsecamente com os estilos de aprendizagem, já que cada indivíduo possui um perfil próprio, sendo fundamental conhecê-los a fim de buscar estratégias para melhorar o desempenho e aperfeiçoar os estilos pouco desenvolvidos. Este estudo objetivou a análise de periódicos sobre a temática proposta com fins de elaboração de uma nova perspectiva, apresentando sua abordagem no ambiente acadêmico. Para a consecução do objetivo, tal estudo teve como metodologia de pesquisa o cunho bibliográfico e exploratório, com uma abordagem qualitativa, averiguando-se artigos científicos nos principais indexadores de periódicos sobre a aplicação da Teoria Kolbiana e sua importância no meio educacional. Diante disso, os resultados alcançados evidenciaram suas contribuições nos processos de ensino e de aprendizagem, demonstrando a necessidade dos educadores adotarem estratégias voltadas aos quatro estilos de aprendizagem, destacando-as como ferramenta para o autoconhecimento a partir de sua identificação e permitindo o contato dos alunos com variadas atividades que contribuirão para o seu conhecimento.
O ESVAZIAMENTO E A FRAGMENTAÇÃO DO CONTEÚDO COMO PROTAGONISTAS DA DISSEMINAÇÃO DAS FAKES NEWS: O CASO DO TERMÔMETRO INFRAVERMELHO
Authors: Calegari Zanatta Shalimar , Azevedo Silva Anna Beatriz , Pereira de Carvalho Hercilia Alves , Calegari Zanatta Alisson
Published: March 2022

Termômetros são instrumentos utilizados para medir a temperatura de um corpo. O modelo conhecido por infravermelho ou pirômetro tem se tornado popular frente as medidas de combate a pandemia. Quando apontado para o indivíduo, é capaz de captar a radiação infravermelha emitida e, assim aferir a temperatura sem necessidade de contato. No entanto, este dispositivo foi alvo de diversas notícias veiculadas pelas mídias sociais. A aferição da temperatura, deixou de ser obtida pela testa, como no início da pandemia, para ser tomada no braço ou nas mãos dos clientes que adentravam o comércio local. Esta mudança de comportamento observada na região, expõe uma preocupação: o poder das notícias falsas ou Fake News no comportamento social. Assim, este artigo discute a necessidade de promover a alfabetização científica, enfatizando os perigos do esvaziamento do conteúdo e expropriação do papel do professor como agente transmissor do conhecimento. Como resultado final, apresentamos os conceitos científicos envolvidos na aferição da temperatura pelo termômetro infravermelho com o intuito de promover e divulgar o conhecimento científico num movimento de oposição às crescentes teorias conspiratórias.
PARTICIPAÇÃO E AUTORIA DE PESSOAS CEGAS NA ELABORAÇÃO DE RECURSOS DIDÁTICOS
Authors: Carvalho Silva Raynara , Monteles Sousa Fabiano , Guelero do Valle Mariana
Published: March 2022

Esta pesquisa teve como objetivo investigar a participação e autoria de pessoas cegas na elaboração de recursos didáticos, tem abordagem qualitativa e tipologia de estudo de caso. Os integrantes da pesquisa são duas pessoas cegas que participaram como convidados da elaboração de um recurso didático com licenciandos do curso de Ciências Biológicas de uma universidade pública do estado do Maranhão. A coleta de dados deu-se por meio de entrevistas semiestruturadas. Os dados coletados foram analisados dialogando com o referencial de Bakhtin (1997) e Bordenave (2013). Os participantes da pesquisa puderam revelar que, ao se abrir espaço para a participação de pessoas cegas, pode-se conhecer sua maneira de perceber o mundo e, assim, elaborar recursos didáticos que contemplem a sua singularidade, garantam a acessibilidade informacional, permitindo sua autonomia nas aulas e a vivência de novas experiências.
Penerapan Media Pembelajaran Holo-Math (Hologram Mathematics) Dalam Meningkatkan Kemampuan Visual Matematis Siswa Di SMP Negeri 8 Percut Sei Tuan
Authors: Lukman Alphiyani , Hairi Anisa Putri , Rahmi Afifah , Fadli Azwar , Dongoran Siti Balqis , Nasution Andrea Arifsyah
Published: March 2022

Kemampuan visualisasi memiliki peran penting dalam pengembangan pemikiran matematis yang berkaitan dengan pemecahan masalah matematika pada topik bangun ruang. Dengan adanya kemampuan visualisasi yang baik siswa dapat menginterpretasikan bentuk-bentuk bangun ruang tersebut sesuai dengan permasalahan yang diberikan. Beberapa penelitian sebelumnya (Syahputra, 2013; Kariadinata, 2010; Isnaini, 2017) yang mengatakan bahwa siswa masih mengalami kesulitan dalam memahami objek atau gambar bangun ruang 3D. Penelitian ini bertujuan untuk mendiskripsikan adanya pengaruh media pembelajaran HOLO-MATH (Hologram Mathematics) dalam meningkatkan kemampuan visual matematis siswa di SMP Negeri 8 Percut Sei Tuan. Dalam penelitian ini penulis menjelaskan secara deskriptif tentang pengaruh hasil belajar siswa. Penelitian ini dilakukan di kelas VIII yang terdiri dari 27 orang siswa. Metode yang digunakan pada penelitian ini adalah Research and Development dengan model ADDIE. Pengumpulan data diperoleh dengan Data Triangulation. Hasil dari penelitian ini yaitu terlihat adanya peningkatan dari hasil belajar siswa setelah belajar dengan menggunakan media pembelajaran HOLO-MATH. Hal tersebut dapat ditunjukkan dari perbandingan hasil pre-test dan post-test siswa yang mengalami peningkatan dari hasil sebelumnya dengan persentase N-Gain sebesar 32,9%. Melalui proses pengerjaan jawaban siswa, terlihat juga kemampuan visual matematis yang meningkat. Dengan demikian terjadi pengaruh yang signifikan dalam meningkatkan kemampuan visual matematis siswa ketika menggunakan media pembelajaran HOLO-MATH. [Penerapan Media Pembelajaran Holo-Math (Hologram Mathematics) Dalam Meningkatkan Kemampuan Visual Matematis Siswa Di SMP Negeri 8 Percut Sei Tuan
The effect of investment diversification on return and risk of private banks in the implementation on monetary policy
Authors: Abbasnezhad Parisa , Miladiyan Hossein
Published: March 2022

The present study evaluates the effect of investment diversification on the return on investment and risk as long as the central bank's monetary policy factors will affect how banks investment. Methodology: This study has a descriptive-correlation nature that has analyzed the financial information of 10 active banks in Tehran stock exchange in the period of 1388 to 1392 using the SPSS version 21. In this study Hirschman-Herfindahl index (HHI) was used to evaluate the investment diversification level of banks in various economic parts. The normality of research data, the holograph – Esmirnoph test has been used and the Durbin Watson test was used for investigating the independence among errors. Results: The (ANOVA) variance analysis test has been used for investigating the meaningfulness of regression. Results showed that investment diversification has a negative and inverse effect on investment return and risk. Conclusion: Also any of control variable and interfere has no effect on investment return and bank risk.
A Study on the Impact of Proficiency on Work Engagement in Public Sector
Authors: Yaghoubi Normohammad , Hosseinbor Mohammad Osman , Yaghoubi Mohsen
Published: March 2022

Work engagement has received a great body of research in recent years. Consequently, identifying the antecedents and outcomes of this phenomenon is regarded as important research topics. This paper investigates the association of work engagement and proficiency. Methodology: Proficiency has been studied as an antecedent of work engagement in this article.  The suggested relation was examined in a sample of 395 employees in four public organizations in Iran. Results: The finding indicates that there is a positive and significant relationship between work engagement and proficiency. Conclusion: Moreover, only one of the subscales of proficiency (organization member proficiency) could predict the variance of work engagement.
Congenital combined vitamin K-dependent clotting factors deficiency: case reports
Authors: Florinskiy D. B. , Zharkov P. А. , Pshonkin A. V. , Poletaev A. V. , Fedorova D. V. , Seregina E. A.
Published: March 2022

Congenital combined vitamin K-dependent clotting factors deficiency is an extremely rare bleeding disorder, a few cases have been described worldwide. This coagulopathy requires a differential diagnosis with vitamin K deficiency bleeding of the newborn and coagulopathy, associated with different liver disease. The world practice of treating this hemorrhagic condition is the use of vitamin K 1 (not registered in the Russian Federation), as well as a prothrombin complex concentrate. This article describes the clinical manifestations, diagnosis and specific treatment in 2 patients with this bleeding disorder. The patients' parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.
Сongenital infantile fibrosarcoma with a non-canonical TPM3-NTRK1 fusion transcript: a case report and a literature review
Authors: Ivanov N. S. , Panfyorova A. V. , Konovalov D. M. , Teleshova M. V. , Bolshakov N. A. , Shamanskaya T. V. , Druy A. E. , Kachanov D. Yu.
Published: March 2022

Infantile fibrosarcoma (IFS) is a rare malignant soft tissue tumor characterized by local invasion, a low rate of distant metastasis (1–13%), and manifestation during the first years of life. Overall survival rates range from 89 to 94%, event-free survival rates – from 81 to 84%. Classic IFS is characterized by t(12;15)(p13;q25) translocation resulting in the formation of the ETV6-NTRK3 fusion transcript. However, over the past few years, there have been numerous reports of IFS-like tumors with non-canonical genetic aberrations (BRAF, NTRK1, MET genes) whose prognosis is less predictable. Here we report a rare case of congenital IFS with involvement of subcutaneous fat, indolent course and a non-canonical TPM3-NTRK1 fusion transcript identified in the soft tissue and intradermal tumor components with different histological features. The patient’s parents gave their consent to the use of their child’s data, including photographs, for research purposes and in publications. The literature review explores modern algorithms for the diagnosis and treatment of IFS in children, including the use of new therapies, such as tropomyosin receptor kinase inhibitors, as well as algorithms for detecting NTRK1, NTRK2, NTRK3 gene rearrangements in solid neoplasms in general, and soft tissue tumors in particular.
Analysis of genetic aberrations in pediatric low-grade gliomas: the experience of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
Authors: Papusha L. I. , Zaytseva M. A. , Panferova A. V. , Valiakhmetova А. F. , Voronin K. A. , Salnikova E. A. , Vilesova I. G. , Druy A. E. , Karachunskiy A. I. , Novichkova G. A.
Published: March 2022

Low grade gliomas (LGGs) are the most common brain tumors in children. Our retrospective-prospective study of biological characteristics of sporadic LGGs (not associated with neurofibromatosis type I) included 233 patients aged 0 to 18 years who had been diagnosed and/or treated at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology in the period from 2009 to 2021. The study was approved by the Independent Ethics Committee and the Scientific Council of the D. Rogachev NMRCPHOI. The median age at the diagnosis was 5 years 4 months (2 months – 17 years). Among the LGGs, the following histological variants were identified: pilocytic astrocytoma (n = 191; 82%), pleomorphic xanthoastrocytoma (n = 16; 7%), ganglioglioma (n = 7; 3%), desmoplastic infantile ganglioglioma (n = 4; 2%), diffuse leptomeningeal glioneuronal tumor (n = 5; 2%), dysembryoplastic neuroepithelial tumor (n = 2, 1%), and diffuse astrocytoma (n = 1; 0,5%). The tumors were located in: the suprasellar region (n = 98; 42%), the brainstem (n = 40; 17%), the cerebellum (n = 35; 15%), the hemispheres (n = 34; 15%) etc. The KIAA1549-BRAF fusion was the most common molecular genetic alteration (n = 107; 46%). The second most frequent genetic aberration was the BRAF V600E mutation (n = 44; 19%). Rare molecular genetic events leading to the activation of the MAPK signaling pathway were detected in 13 (6%) patients. The H3 K27M mutation associated with an aggressive clinical course was identified in three patients with brainstem LGGs (1%). These findings point to the importance of molecular profiling of pediatric LGGs for the selection of an effective strategy for molecular diagnosis and optimal clinical care.
Chronic myeloid leukemia in children: a rare and unique entity
Authors: Boychenko E. G.
Published: March 2022

Chronic myeloid leukemia (CML) rarely occurs in the first two decades of life, accounting for 2% to 3% of leukemias in children and adolescents. Because of a lack of robust clinical study evidence, management of CML in children is not standardized and often follows guidelines developed for adults. Children and young adults tend to have a more aggressive clinical presentation than older adults, and recent data indicate that some genetic differences exist in pediatric and adult CML. Because children with CML may receive tyrosine kinase inhibitor (TKI) therapy for many decades, and are exposed to TKIs during a period of active growth, the acute and long-term toxicities of this option should be carefully evaluated against the complications associated with lifelong use of TKIs. This review aims to outlines the morphological, genetic and immuno-phenotypical findings of pediatric CML, and to recommend a uniform approach for the diagnostic procedures to be applied and for standardized treatment.