bluuebunny/crossref_metadata_2025 huggingface dataset:
Ameliorative Potential of Menstrual Blood-derived Endometrial Stem Cells in Alcohol-Induced Fatty Liver Disease
Authors: Jiang Yan , Huo Qingyang , Gao Jingwen , Kou Beilin , Mohd Yusoff Narazah , Jairaj Moses Emmanuel , Lin Juntang
Published: October 2024

Background:

Alcohol-induced fatty liver disease (AFLD) begins with steatosis and
may progress to a range of pathological liver changes, including fibrosis, cirrhosis, and complications.
Menstrual blood-derived endometrial stem cells (MenSCs) have shown potential therapeutic
effects against various types of liver damage. However, the liver-protective effects of MenSCs
in AFLD are not well understood. This study aimed to evaluate the therapeutic effects of MenSCs
on AFLD progression.

Methods:

MenSCs were sourced from women in good health (N=5, 25-34 years old). Male
C57BL/6 mice were separated into three distinct groups to establish the mouse models. The AH/-
MenSCs group received MenSCs (5×105 cells/mouse) transplantation through tail injection on the
7th and 13th days following the initiation of the alcohol-induced fatty liver model. The therapeutic
effects of MenSCs transplantation in AFLD mouse models were subsequently explored using
qPCR, Western blotting, histopathological examination, and mRNA sequencing analysis.

Results:

MenSCs significantly improved liver function and reduced lipid accumulation in AFLD.
Treatment with MenSCs was also found to reduce the expression levels of inflammatory cytokines
and profibrotic markers in the liver tissues of the mouse model. Additionally, the MenSCs-
treated group demonstrated a significant reduction in endoplasmic reticulum (ER) stress and
oxidative stress, along with an increase in autophagic activity.

Conclusion:

The findings provided preliminary evidence of the multifaced protective effects of
MenSCs in AFLD.
Ketogenic Diet and Endocrine and Metabolic Diseases: A Bibliometric Study and Visualization Analysis
Authors: Zhang Xinwei , Jiang Yanfei , Cai Tiantian , Huang Zhaowei , Wu Yuqing , Zhang Jinan
Published: October 2024

Background:

The ketogenic diet, known for its high-fat, low-carbohydrate composition,
has been extensively studied in endocrine and metabolic diseases. This study carried out bibliometric
analysis to examine the research trends in this field over the past 20 years, aiming to
provide insights for future studies.

Methods:

We searched the Web of Science Core Collection for all relevant papers. VOSviewer
was used for network visualization, the bibliometrix package of R software (version 4.3.0) was utilized
for data analysis, and CiteSpace was employed for mapping and trend analysis.

Results:

This study encompassed 508 relevant articles spanning from 2003 to 2023, authored by
2827 researchers from 887 institutions across 57 countries/regions. The total number of publications
increased from 3 in 2003 to 508 in 2023, showing a steady growth trend. The United States
emerged as the predominant contributor in this field, followed by Italy and China. Notably, SAJOUX
I consistently exhibited high activity in this field, according to the analysis, with an h-index
of 13. The journal Nutrients has consistently made substantial contributions to this field, accounting
for 19% of all publications. The keywords “obesity,” “ketogenic diet,” and “weight loss” appeared
most frequently, with “obesity” occurring 163 times.

Conclusion:

This study used a bibliometric method to analyze the impact of the ketogenic diet on
the endocrine metabolic system. The research identifies recent frontiers and trending directions,
providing valuable references for scholars in this field
Beneficial Effects of Berry Fruits on Autoimmune Diseases
Authors: Ozdemir Yasin , Ozturk Aysun , Erbas Fatih Gokhan
Published: October 2024

The prevalence of autoimmune diseases in developed societies suggests the
use of natural products for prevention and treatment. At the beginning of preventive
approaches, the idea of regularly consuming herbal products that can have positive
effects on autoimmune diseases and making them a part of the diet is common.
Beneficial phytochemicals can be reached by consuming these herbal products directly
and/or the products obtained from them. In addition, numerous studies have
demonstrated that berries offer the potential to protect against autoimmune diseases if
they are consumed regularly with their phytochemicals, especially phenols,
anthocyanins, vitamins, and specific minor components. There are also studies on the
effects of these phytochemicals on autoimmune diseases. It is stated that the regular
consumption of berry fruits increases the quality of life, and the protective effect it
provides is much easier and less costly than the treatment of autoimmune diseases. This
chapter is aimed at revealing the potential of berry fruits to protect from autoimmune
diseases, reduce the negative effects of the disease, and/or support treatment. Although
studies on the beneficial effects of berries have increased in recent years, they are still
behind other fruits.
History and General Information of Vitamin D
Authors: Afrin Amina , Kalsekar Anam Shakil , Jalal Khawla , Sohail Rahab , Khaleel Sharfa , Saleh Shaima T. , Papandreou Dimitrios
Published: October 2024

The historical background of vitamin D for well-being dates to the
beginning of the twentieth century. There are two types of vitamin D; ergocalciferol
(D2) and cholecalciferol (D3). While D3 is mostly produced in the skin when exposed
to sunshine, vitamin D2 is sourced from plant sources and is frequently utilized in
fortified meals and supplements. The recommended form of vitamin D for
supplementation is D3 since it has a greater potency in elevating and sustaining blood
levels of the nutrient. The biochemistry of vitamin D is centered on how it becomes
activated in the kidneys and liver to become its active form, which controls the
metabolism of phosphorus and calcium. Although ideal serum levels might vary based
on personal health considerations, recommended values generally lie between 20 and
50 ng/mL. Egg yolks, fortified dairy products, and fatty fish are good dietary sources of
vitamin D; nevertheless, obtaining a sufficient intake only through food may be
difficult, necessitating supplementation. However, overindulgence can result in
toxicity, which is defined by hypercalcemia and associated symptoms including nausea
and weakness. This emphasizes the significance of moderation in supplementing.
Because vitamin D is fat-soluble, the body will keep excess rather than quickly excrete
it, therefore taking too many supplements can be harmful. While vitamin D is essential
for many body processes, getting the right amount of it without running the risk of
negative side effects is crucial.
Vitamin D and Cardiovascular Diseases
Authors: Ali May , Masaad Alyaa , Papandreou Dimitrios
Published: October 2024

Vitamin D is an essential micronutrient crucial for various physiological
functions in humans, notably impacting calcium metabolism, skeletal integrity,
immune response, and cellular proliferation and differentiation. While predominantly
synthesized through sunlight exposure, dietary intake, and supplementation also
contribute to its availability. Vitamin D deficiency has been implicated as a potential
risk factor for atherosclerosis, cardiorespiratory distress, and cardiovascular diseases
(CVDs), including sudden cardiac death, hypertension, and stroke. Observational
studies have indicated an inverse correlation between circulating vitamin D levels and
the incidence of CVDs; however, causality remains ambiguous. Some evidence
suggests a potential cardioprotective effect of vitamin D supplementation, however,
further investigation is warranted to elucidate its precise role in cardiovascular health.
This review aims to comprehensively present existing literature on the relationship
between vitamin D status and CVDs.
ANALISIS PENGARUH PERTUMBUHAN EKONOMI DAN INVESTASI TERHADAP TINGKAT PENGANGGURAN TERBUKA PROVINSI BALI 2019-2022
Authors: Syach Ariq Athira , Badriyah Nurul
Published: October 2024

The purpose of this study is to analyze the effect of investment and economic growth on the open unemployment rate in Bali Province in 2019-2022. This research uses quantitative research methods and multiple linear regression analysis methods. The research uses secondary data sourced from the central statistics agency and the investment coordinating agency and panel data methods. The results of the study show that economic growth has a significant and negative effect on the level of open unemployment; This means that an increase in economic growth causes a decrease in the unemployment rate, whereas if economic growth decreases it causes the unemployment rate to decrease. Furthermore, investment has an insignificant and positive effect on the unemployment rate; This means that an increase in the investment value causes the unemployment rate to increase, whereas if there is a decrease in the investment value it causes the unemployment rate to decrease.
La educación artística en el marco legal ecuatoriano y los derechos culturales: pertinencia y calidad hacia el pensamiento creativo e innovador
Authors: Álvarez-Galeano Manuel , Cabrera-Berrezueta Bolívar , Pulla-Merchán Jhoana Fernanda , Crespo-Crespo Walter Benigno
Published: October 2024

Se presenta un trabajo de revisión descriptiva y comparativa que tiene por objetivo cotejar las políticas públicas en el ámbito ecuatoriano y los derechos culturales y artísticos, para establecer una fundamentación sobre la educación pertinente y de calidad y la formación docente en torno a la educación inicial. Se consideró un método no experimental, con enfoque mixto y con una perspectiva inductiva-deductiva, a partir de la declaración de los derechos cultural de Friburgo, un paralelo entre el Plan de Desarrollo por el Nuevo Ecuador, así como la Ley Orgánica de Educación Intercultural (LOEI) y el currículo nacional. Este bosquejo está orientado por la pertinencia educativa y el desarrollo del pensamiento creativo e innovador, desde la mirada de la relación dicotómica entre el sujeto social y el pedagógico, en coordinación con la experimentación en el ejercicio docente. Dicho esto, se deduce que la educación artística cuenta con una trascendencia epistemológica y social, evolucionando desde la óptica tradicional hasta entender al estudiante como entidad creativa. Asimismo, el eje transdisciplinario de las artes coadyuva a que el plano curricular no se limite al conglomerado de competencias de una asignatura o un área, sino también a la inclusión de otras ramas, como método y estrategia. En torno al régimen constitucional ecuatoriano, se puede decir que hay una preocupación por vincular a la cultura y las expresiones artísticas, como elemento complementario a la educación, dentro de una respuesta al principio rector del buen vivir.
Sustentabilidad turística y social en la comunidad Santa Cruz de Palenque Chiapas, México
Authors: Ramón Hernandez Pedro , Pérez Hernandez Dulce , Zea Gordillo Reyna
Published: October 2024

En los últimos años, el turismo rural ha sido un importante generador de recursos económicos para las comunidades que lo practican. Esta investigación se desarrolló a partir de la idea de que en los lugares donde existen atractivos turísticos y los miembros de la comunidad viven de actividades agrícolas y ganaderas, al identificar la actividad turística como una alternativa que complementa sus ingresos, la aprovechan para acceder a una mejor calidad de vida. El objetivo fue identificar comunidades de Chiapas que comparten sus atractivos, y explicar cómo las dimensiones social y turística de la sustentabilidad, son desarrolladas en esos destinos turísticos. La investigación se desarrolló en la comunidad Santa Cruz en Palenque, Chiapas, se abordó desde un enfoque cualitativo con un método de estudio de caso; en esta comunidad se cuenta con un balneario y unas grutas, que recientemente se ofrecen a los turistas. Se trabajó con un grupo focal y se hizo observación en la zona; los resultados indican que las acciones que emprenden los integrantes del comité de administración que gestiona los dos atractivos turísticos, están relacionadas al turismo comunitario, además que derivado de cursos recibidos sobre turismo, poseen las capacidades para anteponer la atención hacia el turista, también han realizado trabajo comunitario y coordinado, lo que ayuda a alcanzar un alto nivel de desarrollo en la comunidad, sus ingresos económicos son mejores y se han organizado para seguir realizando las actividades agrícolas que antes desarrollaban, lo que permite inferir que existen elementos relacionados con un turismo sustentable.
Propuestas de fortalecimiento identitario para el territorio ancestral del Valle del Chota a partir de sus textualidades oralitegáficas
Authors: Chamorro Jimena , Ávalos Flórez Edison
Published: October 2024

Durante seis meses, desde junio a diciembre de 2023, el equipo de investigación desarrolló un trabajo etnográfico en las comunidades afroecuatorianas de Piquiucho, Tumbatú, Mascarilla, la Concepción y Mira, todas pertenecientes a la región de la cuenca del río Mira, una zona ubicada en la provincia ecuatoriana del Carchi, la cual es definida étnicamente por los pobladores como el territorio ancestral del Valle del Chota. El objetivo fue diseñar con la comunidad varias propuestas de intervención didáctica que, nacidas desde el seno de los pobladores, líderes sociales, investigadores y ancianos sabios de cada localidad, sirvieran para generar procesos de fortalecimiento de identidad cultural a partir de las textualidades oralitegráficas. Aquí se ofrecen siete propuestas que plantean la necesidad de redefinir las valoraciones que las comunidades están construyendo en torno a sus prácticas culturales, especialmente aquellas que generan una articulación narrativa entre lo oral, lo escrito y lo pictográfico
Mejorando las habilidades de expresión oral de estudiantes de nivel A2 utilizando la herramienta web ChatGPT
Authors: Gonzalez Cordova Nora , Villao Maridueña Roberto , Del Rosario Guiracocha Alvaro , Alvarado Pignataro Daniella
Published: October 2024

El presente estudio analizó el impacto de la herramienta web ChatGPT en la mejora de las habilidades orales de los estudiantes de nivel A2 del Marco Común Europeo de Referencia para las Lenguas (MCER) de la Universidad de Guayaquil, Ecuador, abordando el desafío de incorporar tecnologías emergentes en el aprendizaje del inglés. El objetivo del estudio fue proporcionar recomendaciones basadas en evidencia para su implementación como herramienta de enseñanza y evaluar su eficacia en la mejora de la competencia oral en este contexto educativo. Empleando un enfoque cuantitativo mediante pruebas previas, posteriores y encuestas, el estudio encontró mejoras significativas en las habilidades orales, especialmente en fluidez y pronunciación. Asimismo, reveló actitudes positivas de los estudiantes hacia las capacidades interactivas y atractivas de ChatGPT. Las conclusiones subrayan el potencial de ChatGPT como tecnología educativa transformadora y recomiendan su inclusión sistemática en las prácticas de enseñanza de idiomas.
Modelo Canvas como estrategia pedagógica en la enseñanza de emprendimiento y gestión en una Unidad Educativa
Authors: Velasco Herrera Viviana , Mantilla Falcón Marcelo
Published: October 2024

Las estrategias pedagógicas son fundamentales en la acción educativa en todos los niveles escolares, su función está orientada a mejorar los procesos y los aprendizajes de manera significativa. Bajo estas consideraciones, la presente investigación tiene como propósito evaluar la estrategia pedagógica basada en el modelo de negocios CANVAS para la enseñanza de la unidad pedagógica “emprendimiento” en estudiantes de educación media de una institución educativa de Ecuador. Se trata de una investigación descriptiva, explicativa, de campo y longitudinal, de diseño cuasiexperimental con muestreo no probabilístico. Participaron tres paralelos (grupos): dos “A y C” considerados el grupo experimental y el “B”, el grupo control. Se aplicó Análisis Exploratorio de Datos (AED) y componentes de la estadística inferencial como Ji cuadrado, U de Mann Whitney y Shapiro Wilk para verificar normalidad de los datos. Se evidencia que la intervención pedagógica mejora ampliamente el rendimiento escolar y los aprendizajes significativos. Se concluye que las estrategias pedagógicas son necesarias y válidas en la acción educativa porque implica innovación, creatividad y compromiso para su aplicación efectiva y objetiva.
Diagnóstico cultural de ciudadanía mundial de estudiantes de Educación Superior en la ciudad de Quito-Ecuador
Authors: Rodriguez Andrea , Esparza Hernández Pablo
Published: October 2024

El bienestar educativo es un eje de la responsabilidad social institucional para promover un servicio educativo que acondicione a los ciudadanos con competencias, valores, y conocimientos. El objetivo de la metodología fue diagnosticar comprensiones culturales de una muestra de 358 estudiantes. El modelo se enfoca en el constructo “la armonía de los sistemas complejos ancestrales comunitarios” desde siete dimensiones sobre las cuales se ha desarrollado un cuestionario de 204 preguntas que exploran el conjunto de conocimientos, valores, costumbres, tradiciones, hábitos, modos de vida y habilidades que se posee los encuestados. Se confirma, que si bien hay un conocimiento de los temas generales de las 7 dimensiones, se requiere un enfoque en 4 de las 7 dimensiones, y sobre todo, en el componente de investigación para promover buenas prácticas de aquellas dimensiones que se deben reforzar con los estudiantes en el aula. La dispersión observada en los datos se debe a la falta de comprensión de las dimensiones de cultura y a la desigualdad de las respuestas de los participantes. La desigualdad social o brecha cultural se asocia a la falta de equilibrio en los factores que rigen el desarrollo de una sociedad.
A Real-Life Laboratory Setting for Clinical Practice, Education, and Research in Family Systems Care: Protocol for a Transformational Action Research Study
Authors: Huber Evelyn , Harju Erika , Stark Elisabeth , Fringer André , Preusse-Bleuler Barbara
Published: October 2024

Background

Burdening health and illness issues such as physical or mental illnesses, accidents, disabilities, and life events such as birth or death influence the health and functioning of families and contribute to the complexity of care and health care costs. Considerable research has confirmed the benefits of a family systems–centered care approach for patients, family caregivers, families, and health care professionals. However, health care professionals face barriers in working with families, such as feeling unprepared. Family systems–centered therapeutic conversations support families’ day-to-day coping, resilience, and health. A family systems care unit (FSCU) was recently established as a real-life laboratory at one of the Swiss Universities of Applied Sciences. In this unit, health care professionals offer therapeutic conversations to families and individual family members to support daily symptom management and functioning, soften suffering, and increase health and well-being. These conversations are observed in real time through a 1-way window by other health care professionals, students, and trainees and are recorded with video for research and education. Little is known about how therapeutic conversations contribute to meaningful changes in burdened families and the benefits of vicarious learning in a real-life laboratory setting for family systems care.

Objective

In this research program, we aim to deepen our understanding of how therapeutic conversations support families and individuals experiencing burdening health and illness issues and how the FSCU laboratory setting supports the learning of students, clinical trainees, and health care professionals.

Methods

Here we apply a transformational action research design, including parallel and subsequent substudies, to advance knowledge and practice in family systems care. Qualitative multiple-case study designs will be used to explore the benefits of therapeutic conversations by analyzing recordings of the therapeutic conversations. The learning processes of students, trainees, and professionals will be investigated with descriptive qualitative study designs based on single and focus group interviews. The data will be analyzed with established coding methods.

Results

Therapeutic conversations have been investigated in 3 single-case studies, each involving a sequence of 3 therapeutic conversation units. Data collection regarding the second research question is planned.

Conclusions

Preliminary results confirm the therapeutic conversations to support families’ coping. This renders the FSCU a setting for ethically sensitive research. This program will not only support the health and well-being of families, but also contribute to relieving the financial and workforce burdens in the health and social care system.

International Registered Report Identifier (IRRID)

DERR1-10.2196/53090
An Online Tailored COVID-19 Vaccination Decision Aid for Dutch Citizens: Development, Dissemination, and Use
Authors: Preuhs Katharina , Bussink-Voorend Daphne , van Keulen Hilde M , Wildeman Ilona , Hautvast Jeannine , Hulscher Marlies , van Empelen Pepijn
Published: October 2024

Background

Since December 2019, COVID-19 led to a pandemic causing many hospitalizations and deaths. Vaccinations were developed and introduced to control viral transmission. In the Dutch context, the decision to accept vaccination is not mandatory. An informed decision is based on sufficient and reliable information, in line with one’s attitudes and values, and with consideration of pros and cons. To support people in informed decision-making, we developed an online COVID-19 vaccination decision aid (DA).

Objective

This article aims to describe the development, dissemination, and use of the DA.

Methods

Building on a previously developed DA, the COVID-19 vaccination DA was developed in 3 phases following a user-centered design approach: (1) definition phase, (2) concept testing, and (3) prototype testing. End users, individuals with low literacy, and experts (with relevant expertise on medical, behavioral, and low literacy aspects) were involved in the iterative development, design, and testing, with their feedback forming the basis for adaptations to the DA.

Results

The DA was developed within 14 weeks. The DA consists of 3 modules, namely, Provide Information, Support Decision-Making, and Facilitate Actions Following a Decision. These modules are translated into various information tiles and diverse functionalities such as a knowledge test, a value clarification tool using a decisional balance, and a communication tool. The DA was disseminated for use in May 2021. Users varied greatly regarding age, gender, and location in the Netherlands.

Conclusions

This paper elaborates on the development of the COVID-19 vaccination DA in a brief period and its dissemination for use among Dutch adults in the Netherlands. The evaluation of use showed that we were able to reach a large proportion and variety of people throughout the Netherlands.
Differences in Messenger RNA Expression of Fibulin-1, Elastin, Matrix Metalloproteinase-1, Basic Fibroblast Growth Factor, and α-Smooth Muscle Actin Between the Ventral and Dorsal Tunica Dartos in Patients With Hypospadias and Chordee: Protocol for a Prospective Cohort Study (Preprint)
Authors: Pitoyo Joko ,   Alvarino, Darwin Eryati ,   Yanwirasti
Published: October 2024

BACKGROUND

Hypospadias is a common congenital anomaly characterized by the displacement of the urethral opening to the ventral side of the penis. Surgical correction is often necessary for functional and psychological reasons. The etiology involves genetic and environmental factors, and chordee, a downward curvature of the penis, is a common complication. Proteins such as fibulin-1, elastin, matrix metalloproteinase-1, basic fibroblast growth factor, and α-smooth muscle actin play roles in hypospadias development.

OBJECTIVE

The study’s aim is to investigate the differences in messenger RNA (mRNA) expression of fibulin-1, elastin, matrix metalloproteinase-1, basic fibroblast growth factor, and α-smooth muscle actin between the ventral and dorsal tunica dartos in patients with hypospadias and chordee.

METHODS

This prospective cohort study aims to investigate differences in mRNA expression of the abovementioned proteins between the ventral and dorsal tunica dartos in patients with hypospadias and chordee. Ethics approval has been obtained, and consent from parents will be obtained before data collection. Eligible participants are aged 6-18 months, diagnosed with hypospadias and chordee, and planned for urethroplasty. Tissue samples will be collected from both aspects of the tunica dartos and analyzed using real-time quantitative reverse transcription–polymerase chain reaction. Data analysis will involve statistical tests and normalization of housekeeping genes.

RESULTS

This study is at the protocol development stage. A pilot study regarding its feasibility has been ongoing as of August 2023. The study results are expected to be available by the end of 2024.

CONCLUSIONS

The study of mRNA expressions of various proteins in the tunica dartos of patients with hypospadias and chordee is expected to improve the understanding and expand the knowledge of the pathophysiology of hypospadias and chordee.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/52282
Acceptability and preliminary efficacy of a novel web-based physical activity for the heart (PATH) intervention designed to promote physical activity in adults with obesity: Protocol for a pilot randomized controlled trial (Preprint)
Authors: Kariuki Jacob , Burke Lora E. , Erickson Kirk I. , Sereika Susan , Paul Sudeshna , Cheng Jessica , Biza Heran , Abdirahman Amjad , Wilbraham Katherine , Milton Hether , Brown Cornelius , Sells Mathew , Osei Baah Foster , Wells Jessica , Chandler Rasheeta , Gibbs Bethany
Published: October 2024

BACKGROUND

Even in the absence of weight-loss, any level of physical activity (PA) can reduce the risk of CVD among individuals with obesity. However, these individuals face multifaceted barriers that reduce their motivation and engagement in PA. They prefer programs that are convenient, fun to engage in, and feature people who they can relate to. Yet, there is a paucity of PA interventions that are designed to incorporate these preferences. We designed the web-based PA for The Heart (PATH) intervention to address this gap.

OBJECTIVE

To describe the protocol of a study that aims to examine the acceptability and preliminary efficacy of PATH intervention among 88 insufficiently active adults with obesity aged at least 18 years old.

METHODS

A 6-month pilot randomized controlled trial (RCT), using a parallel design with 1:1 allocation to intervention or control group. The PATH intervention group are given access to the PATH platform, but the resources each participant can access are tailored according to their baseline fitness level. Control group receive a self-help PA handout. Both group self-monitor their PA using Fitbit and have twice/month meetings with either the health coach (intervention) or study coordinator (control). The outcomes at 6-months include acceptability, changes in PA and cardiometabolic risk factors from baseline to 6-months.

RESULTS

N/A

CONCLUSIONS

The PATH intervention offers a promising, evidence-based approach to overcoming the barriers that have hindered previous PA programs for adults with obesity. It can support new and existing program to foster long-term maintenance of health-enhancing PA.

CLINICALTRIAL

NCT05803304
The Influence and Strategies of Generative Artificial Intelligence on Academia, Ethics and Society
Authors: Jia Cai , Juanatas Ronaldo , Niguidula Jasmin D.
Published: October 2024

In the context of the emerging digital environment, generative artificial intelligence (GAI) is quickly becoming implemented in different spheres of life and even begins to replace people in some professions. This means that GAI is leading a new round of technological and industrial revolution. The application and growth of artificial intelligence has improved the society as well as the economy and but has issued many ethical and social problems thus making ethical governance of artificial intelligence more relevant. To contribute to the further development of the concept GAI under the conditions of sustainable development of human society and science, industries and scholars around the world have started researches on this technology. However, as GAI is still an embryonic field, more research efforts must be directed toward this field in the future. Researched articles that compare the use of GAI to the effects on ethical and societal concerns will form the basis of this paper and the resulting discussion of the pros and cons of this technology, this paper considers and demonstrates the difficulties of students, educators, and academics facing the consequences of GAI development. Finally, it has suggestion for the governance of GAI’s next phase of growth.
Cambiando las Universidades de adentro hacia fuera: La importancia de la Innovación Social en la Educación Superior
Authors: Anderson Mark Majewsky
Published: October 2024

A la luz de la actual pandemia covid-19, las universidades deben rotar y trabajar más directamente con sus comunidades locales y globales. Más concretamente, necesitan crear un nuevo paradigma para el intercambio de conocimientos mediante la creación de ‘unidades de apoyo a la innovación social’ que presten valor social a las actividades de las universidades de la misma manera que se han desarrollado las ‘oficinas de transferencia de tecnología’ para aportar valor comercial. Se describe, además el concepto de innovación social como alternativa a formas más comerciales de intercambio de conocimiento, además de nuestra experiencia de establecer las unidades de innovación social en América Latina, Sudeste Asiático y Europa, comparando y contrastando las necesidades de la región, así como las diferentes perspectivas de las propias instituciones de educación superior.
La Valorización del Patrimonio Cultural y la Innovación Social: Nápoles, como caso de Estudio
Authors: Consiglio Stefano
Published: October 2024

Nápoles posee una historia milenaria y los vestigios de este pasado muy lejano, aún son visibles en todas partes de la ciudad y en sus alrededores: áreas arqueológicas, estanques de peces y villas romanas submarinas, hipogeos helenísticos y romanos, castillos, iglesias, monasterios. La inmensidad y concentración de este extraordinario patrimonio cultural, requiere de enormes recursos para asegurar el cuidado, la protección y la puesta en valor necesarios. Estos recursos, casi nunca están disponibles y cuando lo están, a menudo hay una incapacidad injustificable para gastarlos de manera adecuada y eficaz
Desde el modelo Triple Hélice a la Multihelice en los procesos de intervención y desarrollo de núcleos de Innovación Social a nivel local o regional
Authors: González Ramírez José Manuel
Published: October 2024

La situación actual bajo un marco de competencia global nos presenta una singular paradoja, ya que, en una economía basada en la rapidez de las transacciones comerciales, el acceso universal a una comunicación inmediata y de calidad, y mercados completamente abiertos y accesibles, cabría esperar que la importancia de las relaciones locales entre los agentes del sistema disminuyese. Sin embargo, la realidad nos muestra justo lo contrario.
Patrimonio e Innovación Social: Preliminares para una perspectiva de Investigación Aplicada
Authors: Cote Andrea , Concha Roberto
Published: October 2024

Se plantean lineamientos para la investigación e intervención en innovación social en el campo del patrimonio cultural y natural, a partir de los aprendizajes del Modelo Multihélice de Innovación Social de la Universidad Católica del Norte. Para ello se revisan las corrientes de aproximación teórica a la innovación social, se analiza el patrimonio como construcción social, y se retoman las conclusiones de algunos estudios acerca de la relación entre innovación social y patrimonio. Se propone que esta última debe abordarse en dos ejes centrados, primero, en la gestión, y, segundo, en los usos sociales del patrimonio. Asimismo, que para el escalamiento de iniciativas de innovación social patrimonial y para la investigación aplicada es conveniente enfocar la innovación social como un proceso complejo que implica la agencia para la transformación del contexto institucional.
Perancangan Turbin Angin Sumbu Vertikal Lima Sudu Untuk Aplikasi Penerangan Jalan Raya Daya 200 Watt
Authors: Meta Alif , Mahjoedin Yovial , Marthiana Wenny
Published: October 2024

Pada makalah ini dibuat model desain Turbin Angin Sumbu Vertikal (TASV) tipe Savonius. Model CADD dari TASV disiapkan. Pokok masalahnya adalah turbin angin sumbu vertikal dirancang untuk kondisi jalan raya ramai lancar dengan kecepatan angin berubah-ubah arah dan dengan konstruksi sederhana, turbin angin sumbu vertikal dirancang dengan jumlah sudu sebanyak 5 buah. Tujuannya adalah merancang turbin angin sumbu vertikal untuk operasi pada unstable speed (kecepatan tidak stabil), menghitung dan melakukan proses perancangan turbin angin sumbu vertikal dengan 5 buah sudu. Metode pengaplikasian TASV ini ditempatkan di median jalan raya. Kendaraan dari kedua sisi median mempercepat angin sehingga meningkatkan energi kinetiknya yang memaksa sudu turbin berputar searah jarum jam. Ini menggerakkan rotor yang terhubung ke generator DC, sehingga menghasilkan listrik. Listrik ini dapat digunakan untuk berbagai aplikasi seperti penerangan jalan raya. TASV ini juga berfungsi sebagai penghalang lampu jauh yang dipancarkan oleh kendaraan dari jalur berlawanan, sehingga mengurangi risiko kecelakaan. Data yang didapatkan untuk merancang TASV ini adalah TASV dibuat dengan menggunakan bahan yang mudah didapat seperti, dua pelat baja tahan karat dengan bantalan bola, pipa PVC setengah potong, dasar baja ringan dll. Daya rencana sebesar 200 Watt dengan kecepatan angin 8.4 m/s. Perancangan ini dilakukan dengan tujuan untuk bisa merencanakan dan menghitung dimensi sudu turbin, poros, puli, V-belt, dan bantalan yang bertujuan sebagain alat untuk pembangkit energi listrik.
MODERN HISTORIOGRAPHY OF RUSSIAN-CHINESE RELATIONS (2020-2023)
Authors:   Moscow Technical University of Communications and Informatics (Russia), Biryukova K.V.
Published: October 2024

China never ceases to assert itself as an economic and geopolitical leader. Against the background of a pandemic that imperiously intervened in our lives, a crisis in relations between Russia and the United States and a number of European countries, a gradual transition to a multipolar political world, Russian-Chinese relations are constantly developing. The study is historiographical in nature. The author considers some works of the last three years on China, Russian-Chinese diplomatic relations and foreign policy, geopolitical strategies and strategic partnership between the two countries. The field of study also includes individual persons significant for the development of Russian-Chinese relations and the spread of Christianity in China (Savva Lukich Vladislavich-Raguzinsky, Russian diplomat and plenipotentiary ambassador to China, and Russian missionary to China, participant 12 and Head of the 13th and 15th composition of the Russian Orthodox mission in Beijing, sinologist Archimandrite Palladium (Kafarov), Baron F.R. Osten Saquena, Catholic missionary Mateo Ripa). The author is also interested in topical studies that reveal the topic of Russian-Chinese relations in a socio-cultural and religious context. Relevant means research of the last three years (2020-2023). The study is fragmentary in nature, since the scope of the article does not allow for the full presentation of works on Russo-Chinese relations in political, socio-cultural and religious contexts.
ADOLF IOFFE’S EMBASSY: CRISIS MANAGEMENT BETWEEN MOSCOW AND BERLIN IN JULY 1918.
Authors:   Lomonosov Moscow State University (Russia), Vatlin A.Yu.
Published: October 2024

The article puts into scientific use the materials of the Soviet Embassy in Berlin which was opened according to Brest peaceful treaty and operated since April till November 1918. Lack of reliable telegraph connection led to substantial volume of correspondence between A. Ioffe and V. Lenin together with G. Chicherin who determined the Soviet foreign policy. In the chaotic process of formation the Bolshevik political regime the relationship between them went far outside the framework of departmental subordination, and Ioffe cut off from Moscow had to repeatedly assume strategic decisions. Owing to diplomatic blockade of the Soviet Russia his activity fell outside the scope of his duties as an envoy, in his reports he gave the general analysis of German internal economic and military situation, supported close contacts with local left socialists and supervised Soviet foreign propaganda. After count Mirbach, German ambassador, was killed in Moscow 6 July 1918, it was Ioffe who was able to prevent violent political unrest in Soviet-German relationship which threatened to resume military operations between two countries.
Engage and equip: Transformative class activities for the modern accounting semester
Authors: Papakroni Erlina , Lin Tony L. J.
Published: October 2024

Managerial accounting courses struggle with student engagement, often more than other courses, mainly, due to its course content, which differs significantly from the financial accounting courses. This article provides a list of class activities developed and adapted primarily for managerial accounting courses. The purpose of these class activities is twofold. First, they aim to increase student engagement and promote active learning in class. Second, they help students apply acquired knowledge to real-world examples and develop workplace skills that are vital for a successful business career. The activities are designed to be completed within the class time. We have collected and adapted some of these activities from pedagogical training, while the rest were developed based on our teaching experience. Some of these activities incorporate teaching techniques developed while teaching remotely due to the COVID-19 pandemic.
A dosimetric and robustness analysis of proton arc therapy with early energy layer and spot assignment for lung cancer versus conventional intensity modulated proton therapy
Authors: Chocan Macarena S. , Wuyckens Sophie , Dasnoy Damien , Di Perri Dario , Borderias Villarruel Elena , Engwall Erik , Lee John A. , Barragan-Montero Ana M. , Sterpin Edmond
Published: October 2024

Background and purpose: Intensity Modulated Proton Therapy (IMPT) faces challenges in lung cancer treatment, like maintaining plan robustness for moving tumors against setup, range errors, and interplay effects. Proton Arc Therapy (PAT) is an alternative to maintain target coverage, potentially improving organ at risk (OAR) sparing, reducing beam delivery time (BDT), and enhancing patient experience. We aim to perform a systematic plan comparison study between IMPT and energy layer (EL) and spot assignment algorithm – Proton Arc Therapy (ELSA-PAT) to assess its potential for lung cancer treatment.
Material and methods: A total of 14 Lung ELSA-PAT plans were compared retrospectively with IMPT plans. 4D worst-case minimax robust optimization was performed, including 84 scenarios (3%, 3 mm). Dosimetry assessment included target (clinical tumor volume [CTV]) and important OARs, on nominal and worst-case scenarios. Most relevant normal tissue complication probabilities (NTCP), target coverage robustness against interplay effect, and BDT were evaluated.
Results: CTV D95% and D98% showed no significant difference in comparison. PAT demonstrated better conformality by 66% (p = 0.00012) but delivered a higher heart mean dose (HMD, 23%). There was a 2% increase in NTCP 2-year mortality risk with PAT. Total BDT was comparable among techniques. IMPT was more robust than PAT against interplay effect, considering both D1% (1.0 ± 0.8 Gy vs 1.1 ± 1.4 Gy) and D98% bandwidths (0.9 ± 0.9 Gy vs 1.1 ± 1.3 Gy).
Interpretation: Both techniques provide a similar level of dose coverage to the target volume. Although PAT improved dose conformality, higher HMD translated into increased heart toxicity, presumably due to chosen planning methodology and OAR proximity to target. Increased ELs and spots raised PAT BDT, although it could improve daily treatment workflow.
Coverage of mammography imaging in and outside an organized breast cancer screening program – variation by age and sociodemographic groups
Authors: Fuhrmann Joanna , Heinävaara Sirpa , Sarkeala Tytti , Lehtinen Milla , Pankakoski Maiju
Published: October 2024

Introduction: In recent decades, attendance to organized breast cancer screening has been decreasing in European countries. This could be partly due to an increase in the use of opportunistic screening. The aim of this study was to assess the coverage of imaging in and outside the screening program in Finland during the period of 1999–2018. We also compared the usage of imaging services across sociodemographic groups in the more recent years (2017–2018).
Methods: Our initial data consisted of 1,159,000 screening-target-aged women (50–69 years) in 1999–2018 and 1,849,000 women aged 30–89 years in 2017–2018. Data on organized breast cancer screening program was drawn from the Finnish Cancer Registry and supplemented with comprehensive individual data on mammograms and ultrasounds performed outside the program.
Results: Among the screening-aged women (50–69), a clear decline in the overall imaging coverage was observed during the study period (from 89 to 85%). The use of outside imaging increased slightly but not enough to compensate for the overall decrease. There were large differences in coverages between sociodemographic groups. Compared to manual workers and the unemployed, upper-level employees were around two times more active in using outside imaging (8.2% vs. 3.6% and 4.3%, respectively).
Interpretation: Overall breast imaging coverage has slowly decreased during the 2000s, while outside imaging has increased slightly. The coverage of imaging in and outside the program largely followed the same trends, with the highest usage concentrating on higher socioeconomical groups, native speakers and highly educated women.
Sleep Efficiency and Neurocognitive Decline in Atopic Dermatitis: A Systematic Review
Authors: Khosravi Alireza , Glińska Julia , Barańska-Rybak Wioletta
Published: October 2024

Atopic dermatitis is often accompanied by a lack of sleep efficiency, which may impact neurocognitive functions. This review assesses the association between sleep quality in atopic dermatitis patients and neurocognitive decline. Databases searched included PubMed, Scopus, and Web of Science from inception to 8 January 2024, adhering to PRISMA guidelines. Cross-sectional and longitudinal studies were included. Records were screened and assessed for eligibility, with 13 studies included in the final analysis. From an initial pool of 4,529 records, 13 studies involving 272,868 participants met the inclusion criteria. The review identified a consistent pattern of sleep disruption in individuals with atopic dermatitis, which was associated with various short-term neurocognitive challenges such as impaired focus, decreased sleep efficiency, and lower IQ. Limited evidence was found for potential long-term cognitive decline associated with chronic atopic dermatitis. Lower sleep quality in atopic dermatitis is associated with neurocognitive deficits. While immediate effects are evident, further research is needed to understand potential long-term consequences. Integrating sleep management into atopic dermatitis care is imperative.
Rekommendationer för öppen utbildning
Authors: AVOTT Avoimen tieteen koordinaatio
Published: October 2024

I inledningen till Policyn för öppen utbildning och öppna lärresurser nämns nationella rekommendationer för att precisera detaljer i policyn. Rekommendationerna ska hjälpa organisationerna att genomföra åtgärderna i policyn och ge lärare och andra utbildningsanordnare goda tips för att främja öppen utbildning och utnyttja och utarbeta öppna lärresurser.
A INTELIGENTE ESCOLA PARA A GESTÃO ORGÂNICA
Authors: Badiru Ajibola Isau , Ippolito Rita , Santos Núbia Dias dos , Carvalho Andréa Freire de
Published: October 2024

O sistema educacional está passando por uma modernização nas escolas inseridas em rede, mas nem sempre atinge os resultados desejados devido a deficiências organizacionais e conceituais. Este estudo visa redefinir o conceito de escola como um todo integrado—abrangendo representação, operação e gestão—e como uma "agência espacial" dentro de um sistema de gestão inclusiva, refletindo a realidade contemporânea de um sistema aberto. A análise da rede municipal de escolas básicas de Maceió-AL, Brasil, ilustra oito propriedades-chave de uma organização escolar repensada em conformidade com a Agenda 2030. Uma escola inteligente enfatiza quatro aspectos principais: vulnerabilidade, potencial, personalidade e criticidade, que aumentam a visibilidade dos agentes educacionais e elevam a consciência sobre as realidades geográficas e suas questões socioambientais. A avaliação contínua das condições escolares envolve entender padrões e processos, facilitando a busca por soluções para os desafios educacionais que impulsionam a transformação cultural e a integração de valores como colaboração, empatia, respeito, solidariedade, tolerância, responsabilidade e autodisciplina. Uma estrutura escolar em rede incentiva a adaptação e o aprimoramento das forças locais para atender às metas e responsabilidades de uma gestão pedagógica eficaz.
AÇÕES E PRÁTICAS SUSTENTÁVEIS NO AMBIENTE HOSPITALAR
Authors: Pacheco Jucirema Corrêa , Siqueira Gilmar Wanzeller , Farias Ronnie Anderson Nascimento de , Teixeira Diego Figueiredo , Barbosa Nilza Maria Sena , Marques Rubenita Helena Carlos , Siqueira Maria Alice do Socorro Lima , Wanzeller Milena de Lima
Published: October 2024

Este artigo aborda a educação ambiental e a biossegurança no contexto de ações e práticas sustentáveis em ambientes hospitalares, com o objetivo de identificar os principais fatores de risco ambiental e práticas inadequadas presentes nesses espaços. Além disso, busca sugerir boas práticas de educação ambiental e biossegurança para a preservação do meio ambiente. A escolha do tema foi motivada tanto pela experiência profissional quanto pela relevância da sustentabilidade no setor de saúde, destacando a importância de implementar práticas sustentáveis não apenas sob os aspectos ambientais, mas também econômicos e sociais. Foi conduzida uma pesquisa descritiva, bibliográfica, com abordagem observacional não participativa. A coleta de dados foi realizada por meio de um roteiro que descrevia os pontos a serem observados, relacionados aos riscos ambientais e à biossegurança. O estudo foi realizado no Hospital Universitário Bettina Ferro de Souza, vinculado à Universidade Federal do Pará e administrado pela Empresa Brasileira de Serviços Hospitalares. Concluiu-se que os hospitais universitários, como centros de formação de recursos humanos e desenvolvimento de tecnologias para a área da saúde, têm uma responsabilidade importante em seguir as normas regulamentadoras, diretrizes e legislações pertinentes. O compromisso com a sustentabilidade continua sendo um grande desafio global, e os hospitais, por sua natureza, possuem uma responsabilidade essencial para com o planeta. Pequenas mudanças de atitude podem gerar grandes resultados.