bluuebunny/crossref_metadata_2025 huggingface dataset:
Estrategias motivacionales para la mejora del desempeño docente
Authors: Camacho Herrera Julio Dagoberto , Sánchez Balcázar Roberth Alfredo , Hernández Rovalino Liset Rosalva , Paredes Menéndez Guadalupe Elizabeth
Published: May 2023

Introducción. El desempeño del docente tiene que ajustarse a las necesidades de los estudiantes de era digital, utilizando metodologías activas para despertarles el interés de aprender e involucrarlos a los temas de la clase espontáneamente para lograr aprendizajes significativos. Objetivo: demostrar la eficiencia de la aplicación de un programa de estrategias motivacionales que procura la mejora del desempeño profesional docente en el Colegio Fiscal Juan José Plaza Guayaquil - Ecuador. Metodología: Se ha trabajado con una muestra universal de 24 catedráticos, la recolección de la se realizó con un cuestionario de 26 preguntas sobre el desempeño docente; el estudio es de tipo aplicado, cuantitativo, experimental en modo pre-experimental, aplicando pretest y postest para valorar las variaciones del grupo de estudio. Resultados: el contraste de hipótesis manejó la distribución “t” Student para muestras asociadas. Los hallazgos del análisis de datos antes de aplicar las estrategias motivacionales el desempeño docente reveló 58,33% escala media, en el postest mejoró a una escala alta 75%, el contraste de los resultados presenta una diferencia de 37,5%. Conclusiones: se ha demostrado que hubo un cambio significativo en el nivel del desempeño docente.
A case of non-mosaic 47, XXX presenting as placental site trophoblastic, tumor secondary to partial mola
Authors: Tienda-Pimentel Marcos Ivan , Estrada-García Sofía , Tienda Pimentel Liam Eduardo , Sánchez-Valdivieso Enrique
Published: May 2023

Background: Placental trophoblastic tumor is a very rare form of gestational trophoblastic disease (GTD). There are some case reports in which some tumors have been associated with Trisomy X. Objective: is to inform and suggest a possible management for similar cases in a future. Material and methods: A systematic search was carried out in the bibliography and subsequent surgery. Case: Patient with karyotype 47, XXX and ETG. The associated phenotype consisted of a prominent forehead, epicanthal fold in both eyes, micrognathia with dental crowding. The biomarkers CKAE1/AE3, Ki75 were positive. The pathology report suggests an incomplete atypical mole. The final diagnosis was trophoblastic tumor of the placental site. Conclusion: We recommend hysterectomy with preservation of the ovaries if they are not involved.
Sentido Axiológico de la Didáctica: Reinventando la Práctica Docente
Authors: Carriel Villegas Josue Geovanny , Mogrovejo Gomezcoello Lilia Cristina , Noroña Ramírez Eugenia Magdalena , Trávez Vizcaino Segunda Lilia
Published: May 2023

La educación es un sinfín de posibilidades sociales, personales, culturales y epistémicas, concurridas en el sentido del sujeto en formación, quien, desde su esencia, le asigna significado al arbóreo activo de la enseñanza. Por ello, todo docente ha de valerse de una matriz simbiótica entre el niño, niña y su contexto inmediato, atendiéndolo desde su rizoma familiar, histórico y conductual; esta determinación, fecunda en la distribución asertiva de la pedagogía, integrando al escolar en el foco de direccionalidad educativa, donde el aprendizaje, nutre la multiexistencialidad mediadora en el desarrollo del conocimiento; sin embargo, dicha conducta, no puede estar desprovista de la valoración humana, pues, su pragmasis, consolida los cimientos de una moralidad sentida en el cómo y para qué se forma. Características que permiten demarcar como propósito, describir mediante un nodo documental el sentido axiológico de la didáctica basado en una reinvención de la práctica docente; esta noesis, permite una reflexión profunda en la codificación activa del docente en el contexto de la educación general básica de Ecuador, cuya finalidad es, el logro de una disposición permeable e interactiva de la sociabilidad cognitiva, concatenada en la divergencia de las necesidades e intereses escolares; imbricación circundante de voluntad mediadora necesaria en la actitud consciente de las maestras y maestros del futuro.
La carencia de centros especializados para contraventores de tránsito en la Provincia de Santa Elena
Authors: Miranda Torres Eva Julianna
Published: May 2023

En la investigación se realiza un análisis sobre la carencia de Centros Especializados para contraventores de Tránsito en la provincia de Santa Elena, con la finalidad de sistematizar los argumentos que justifican la necesidad de un centro de esa naturaleza, para garantizar a los infractores de tránsito sancionados pena privativa de libertad su derecho a la vida y la integridad física, ya que al ser colocados a cumplir su pena en un centro destinado a delincuentes peligrosos, se pone en riesgos sus derechos constitucionales y convencionales. Para alcanzar el objetivo se analizan los derechos de las personas privadas de libertad en el marco internacional y en el ordenamiento constitucional y legal ecuatoriano, con énfasis en el principio de separación de las personas privadas de libertad de acuerdo con categorías como el sexo o tipo de infracción cometida, en virtud del cual quienes incurren en contravenciones de tránsito deben estar separados de los delincuentes comunes. Finalmente se realiza un análisis de los delitos y contravenciones de tránsito tipificadas en el COIP, y se exponen los fundamentos de la necesidad de un Centro Especializado para contraventores de Tránsito en la provincia de Santa Elena. Se concluye que con la creación del mismos se podrían garantizar de mejor manera el derecho a la vida y la integridad física de los contraventoras de tránsito que son sancionados con una pena privativa de libertad.
Buenas prácticas pedagógicas y la educación socioemocional de estudiantes de 5to grado de primaria
Authors: Mendoza Saldarriaga Ana de Lourdes
Published: May 2023

El artículo tiene como finalidad conocer las buenas prácticas pedagógicas y la educación socioemocional de estudiantes de 5to grado de primaria, se tuvo como método de desarrollo la investigación cuantitativa, utilizando como técnica el cuestionario, esta investigación se realizó en uno de los contextos sociales donde estudian los estudiantes, siendo los estudiantes los principales informantes. Se obtuvieron como variables centrales: buenas prácticas, barreras en la comunicación, docencia estratégica, comunidades de aprendizaje e interacción profesor-alumno. Estas variables representan las relaciones entre ellas que tienen los estudiantes en torno a la figura del profesor en su papel de mediador. Como conclusiones: los estudiantes a través de sus voces dan un significado a sus sentimientos, creencias, y muestran que perciben un mundo desde un sentido particular y social, este tipo de estudios, permite entender cuán importante es escuchar y comprender el sentir de los principales actores respecto a una comunidad de aprendizaje y la apuesta por un entorno de relaciones afectivas, dados que existen relaciones significativas entre las variables Buenas Practicas y Educación Socioemocional.
Evaluación de las fases del ciclo estral de la rata mediante frotis vaginales y mediciones hormonales
Authors: Hernández López Leonor Estela , Mondragón Ceballos Ricardo , Estrada Camarena Erika Monserrat , Mondragón Ceballos Ricardo , Barrios De Tomasi Jorgelina
Published: May 2023

El ciclo ovárico es el proceso de selección, maduración y crecimiento folicular hasta la ovulación y la preparación del útero para la gestación. Ocurre mediante la intercomunicación entre los ovocitos, las células de la granulosa, células de la teca y diversas células del sistema inmune y endócrino. Las funciones celulares están reguladas por las hormonas hipofisiarias: luteinizante (LH) y folículo estimulante (FSH), junto con los esteroides ováricos: estrógenos, andrógenos y progestágenos. Las variaciones en las concentraciones hormonales generan cambios físicos, cognitivos y emocionales en las hembras. Por lo que, al incluirlas como modelos en los protocolos de investigación, resulta necesario evaluar las fases y duración de los ciclos, pues estas variables pueden sesgar los resultados. Para el seguimiento de las fases se han desarrollado diferentes métodos, siendo la evaluación de la citología vaginal el más utilizado aunque poco preciso. Por el contrario, las mediciones hormonales séricas, urinarias, fecales o salivales son más precisas, pero costosas y tardadas. Consecuentemente, lo ideal sería la combinación de varias técnicas de evaluación. Sin embargo, la decisión dependerá de la naturaleza de cada experimento. Esta revisión describe, los mecanismos fisiológicos del ciclo estral y las hormonas que actúan en cada etapa. Describe el ciclo ovárico de la rata adulta, ya que es la especie más usada en el laboratorio como modelo experimental, incluye la evaluación de los cambios celulares del epitelio vaginal, describiendo las principales técnicas de tinción. Por último, refiere los métodos de medición hormonal más comunes con sus ventajas y desventajas.
Descripción y comparación de la dependencia al celular en adolescentes en tiempo de pandemia
Authors: Tobar- Viera Andrea , Acosta Nicole , Mejía-Rubio Andrea , Puchaicela Alex
Published: May 2023

La dependencia del celular se conoce como la necesidad de tener acceso a un dispositivo móvil en una determina situación, esto aparece con mayor frecuencia en los adolescentes debido a la época de transición que están pasando. El tener acceso a un celular permite una conexión amplia a redes sociales, internet o video juegos que pueden generar una adicción y varios problemas psicológicos. Se llevó a cabo una investigación descriptiva y comparativa, de corte transversal, para lo cual se utilizó una muestra de 204 adolescentes en donde el 44.1% fueron mujeres y el 55.9% hombres, con una media de 15,46 años; se utiliza la prueba de Dependencia al Móvil de Chóliz (TDM). Los resultados obtenidos indican una diferencia significativa del nivel de dependencia al celular para el GS (30.30) fue significativamente distinta que el GP (21.43) (t(190)= -4.55, p<0,01). El tamaño del efecto es moderado (d de Cohen=0.637). Se comprueba que el GS tienen niveles medios y altos de dependencia al celular esto indica el mayor tiempo que le dan al uso del celular.
Sindrome post colecistectomia, revision de los complejos mecanismos y entendimiento de un fenomeno medico quirurgico
Authors: Theran León Juan Sebastián , Dulcey Sarmiento Luis Andrés , Cala Acelas María Alejandra , Garzón Mendoza Lucero Andrea , Quintero Ramírez John Sebastián , Forero Buelvas María Camila , Herrera Florez Angélica Vanesa
Published: May 2023

La colecistectomía tiene un excelente resultado terapéutico. Sin embargo, hasta un 15-20 % de los pacientes colecistectomizados continúan teniendo una variedad de síntomas gastrointestinales. El síndrome poscolecistectomía (SPC) se puede definir como síntomas de cólico biliar o dolor abdominal persistente en el cuadrante superior derecho (CSD) con o sin dispepsia, que son similares a los experimentados por el paciente antes de la colecistectomía. Los SPC siguen estando presentes como un reto diagnóstico y terapéutico. El objetivo de este artículo fue revisar críticamente la literatura sobre la magnitud del problema y las posibles explicaciones fisiopatológicas del SPC.
Contabilidad administrativa una herramienta para el desarrollo de la competitividad de las empresas, periodo 2022
Authors: Aquino Pino Roberto Celiano , Richard Benítez Vega
Published: May 2023

El presente trabajo se enmarca dentro de los estudios no experimentales, de tipo descriptivo con métodos de estudio cualitativo y cuantitativos. El objeto de análisis del uso de la contabilidad administrativa como una herramienta para el desarrollo de la competitividad de las Empresas. El área de estudio tomada para el desarrollo de esta investigación es la ciudad de Pilar, perteneciente al departamento de Ñeembucú de Paraguay. Esta ciudad es el distrito principal del departamento y escenario de una dinámica comercial importante para el mismo, cuenta de empresas pequeñas y medianas reconocidas a nivel departamental. El presente estudio indica que el papel de la contabilidad administrativa es el de proporcionar soporte a la toma de decisiones de la micronesias en estudio, así como lo descrito por (Evia Puerto, 2006), ésa es su razón de ser; su utilidad se verá demostrada en la medida en que se logre su principal objetivo. La contabilidad administrativa se enfoca básicamente al futuro de la organización; por ello, es indispensable establecer la relación de la contabilidad administrativa con el proceso administrativo. La primera es una herramienta sumamente útil para las fases de planeación y control del mencionado proceso: en la etapa de planeación, por medio de la utilización de sistemas de planeación y control de utilidades.  Aunque no es obligatoria, la mayoría de los microempresarios utilizan la contabilidad administrativa, siendo que con la mima, describen los registros, datos e información sobre los cuales se tomen decisiones acertadas en torno a la necesidades inmediatas y futura de la empresa.
Comparativo técnico económico entre pórticos especiales a momento de hormigón armado y acero estructural empleando las normativas ACI 318 19, AISC 341 16, AISC 360 22 Y NEC SE DS 2015
Authors: Abril Camino Andrés Rafael , Abril Camino Daniel Eduardo , Cadena Naranjo Clara Estefanía , Pérez Maldonado Ruth Lorena
Published: May 2023

La interrogante frente a que material estructural es más económico hormigón armado o acero, es un cuestionamiento que ha estado en de discusión durante años por diversos ingenieros civiles, el presente artículo considera un sistema estructural (Pórticos Especiales a Momento) y los analiza en 18 arquetipos, 9 en acero y 9 en hormigón armado, variando alturas, números de niveles y distancia entre ejes (crújías). Buscando solventar la interrogante para el sistema estructural planteado. Se analiza mediante un enfoque sismo resistente considerando las especificaciones de la Norma Ecuatoriana de la Construcción, American Concrete Institute, y American Institute of Steel Construction. Donde los 18 arquetipos son estructuras dúctiles, sismos resistentes y cumplen con lo dispuesto en la normativa. Partiendo del diseño sismo resistente se analiza el costo constructivo de los elementos estructurales, tras culminar la presente investigación se ha determinado qué material es más económico en edificios de mediana y baja altura.
Diseño universal de aprendizaje y hábitos de estudio: Una visión integradora de los enfoques inclusivos
Authors: Orquera Saavedra Dina Soledad , Guañuna Carmen Alicia
Published: May 2023

La educación inclusiva ha sido un reto muy significativo en la realidad ecuatoriana, y la adopción del Diseño Universal de Aprendizaje se integra como elemento que contribuirá a la mejora de la atención educativa para todas y todos. Sin embargo, existe información muy escasa respecto de los efectos que la aplicación de este modelo le podría significar a los elementos determinantes del rendimiento escolar, como la formación de hábitos de estudio. El objetivo general de la investigación es determinar la correlación de la ejecución de prácticas orientadas por el DUA con el desarrollo de hábitos de estudio. Optamos por un estudio mixto con el cual se recurre a los participantes de la muestra a través de un test sobre sus hábitos de estudio medidos a través de la escala de Likert. Se encontró que los docentes suelen desarrollar hábitos de estudio con mayor facilidad en los aspectos concernientes a las escalas de la planificación del estudio y la asimilación de contenidos, a comparación de las escalas de condiciones ambientales y utilización de materiales, donde se observa una tendencia opuesta. Se concluye que, la aplicación del DUA influye positivamente en el desarrollo de hábitos de estudio relacionados con la planificación y asimilación de los contenidos mientras que, en ámbitos como las condiciones ambientales y utilización de materiales su influencia es baja.
Currículo por competencias y estrategias didácticas para los estudiantes de la universidad técnica estatal de Quevedo, 2020
Authors: Montoya Zamora Alberto Javier , Medina Ruíz Marco Yamil , Mera Mendoza César Rolando , Arias Muñoz Nury Irlandia , Suárez Anchundia Silvia Gricelda
Published: May 2023

La presente investigación titulada “Currículo por competencias y estrategias didácticas para los estudiantes de la Universidad Técnica Estatal de Quevedo, 2020”. El objetivo propuesto es: Determinar la relación que existe entre el currículo por competencias y las estrategias didácticas para los estudiantes de la Universidad Técnica Estatal de Quevedo, 2020. La metodología se basa en un diseño no experimental de tipo transversal descriptivo, correlacional. Para la medición de las variables, se elaboró como instrumento un cuestionario en el que fue aplicado bajo la técnica de la encuesta a los estudiantes de la Universidad Técnica Estatal de Quevedo. El instrumento se sustenta en los ítems basados en las dimensiones de las variables: currículo por competencias con sus cuatros dimensiones; competencias cognitivas, competencias metacognitivas, competencias sociales y competencias afectivas. Y de la variable estrategias didácticas con sus dimensiones; estrategias para activar conocimientos, estrategias para orientar la atención, estrategias para organizar la información, estrategias para promover enlace entre los conocimientos previos. Los hallazgos del trabajo de campo analizado estadísticamente demostraron que el currículo por competencias se relaciona con las estrategias didácticas de forma significativa, según se deduce de la correlación (r=0.819) significativa (Sig.=0.00<0.05); este resultado aporta evidencias para aceptar la hipótesis general de la investigación, y se rechaza la hipótesis nula. Es decir existe relación significativa entre el currículo por competencia y las estrategias didácticas en los estudiantes de la facultad de ciencias empresariales de la Universidad Técnica Estatal de Quevedo, 2020. Los resultados indican además que las estrategias didácticas se encuentran relacionadas con las competencias cognitivas, metacognitivas, sociales y afectivas.
Riwayat Isrāiliyyāt
Authors: Mukarromah  , Rika Sartika
Published: May 2023

Efforts to interpret the Qur'an have never stopped being carried out by Muslims. Awareness of the importance of understanding the Qur'an motivates mufassir to interpret the verses of the Qur'an. In addition, with the interpretation, scientific insights are increasingly developing from generation to generation to help various problems in human life. Thus the existence of the Qur'an will always be preserved. The interpretation of the Qur'an was carried out during the time of the Prophet Muhammad saw. The Qur'an handed down by Allah is understood, interpreted, and explained by the Messenger of Allah to the companions. After the Prophet died, the companions had difficulty understanding the verses of the Qur'an related to past events. However, there are Muslims who were previously Jews and Christians (ahlu kitab) who knew of past events. The events they presented for the interpretation of the Qur'an are what is called the history of isrāiliyyāt. In the development of interpretation, it is known that many of the books of interpretation multiply the history of isrāiliyyāt. History is taken to explain the meaning of the verses of the Qur'an. In addition to clarifying understanding, sometimes mufassir deliberately cites the history of isrāiliyyāt for criticism. There are even mufassir who like to take the history of isrāiliyyāt because mufassir is also a muballigh. Regarding the historical law of isrāiliyyāt, some scholars accept, and some refuse. However, some opinions can mediate between the two. It is explained that if the history of isrāiliyyāt corresponds to shari'a, then it can be taken. If the history does not correspond to shari'a it is forbidden to take it. Whereas if the history of isrāiliyyāt is silenced by shari'a, then it is not punished by anything.
Keparalelan Fisika Modern dengan Nilai-Nilai Tasawuf
Authors: Saparwadi Saparwadi , Akhmad Sahrandi
Published: May 2023

The world of physics for scientists is no longer a materialist empirical world, but leads to efforts to realize spirituality through science to find the highest essence of science. There is a parallel in thought between Sufism and modern physics, where Sufism is based on direct understanding into the natural world of reality and modern physics is based on on observations of natural phenomena and scientific experiments which are interpreted and communicated through words which will become too abstract when close to reality which causes awareness of facts. Sufism has very many values in modern physics, but this may be unnoticed by the Muslim community. Whereas in Sufism which takes the verses of the Qur'an there are many things that are actually in modern physics quantized in the form of formulas, which we can take as the rationality of the highest existence of the Creator (Allah Subhaanahu Wa Ta'ala). so that modern physics can be used as an analysis of the verses of the Qur'an in demonstrating the essence of spirituality. This study uses the Library Research method with the main data source from the library in the form of books, articles, encyclopedias, dictionaries, and other written sources. To collect data through several stages, namely data inventory through collection of scientific works. The results of the research show that there are parallels between the thoughts in Sufism and modern physics regarding matter in this universe.
Extra Discussion on Environmental Law for Several Cases in Industrial Zones
Authors: Anh Thu Nguyen , Trong Diep Nguyen , Hung Nhan Pham
Published: May 2023

The study purpose is to present Extra Discussion on Environmental Law for several cases in industrial clusters. Method: qualitative and analytical methods, descriptive method for primary model, synthesis and discussion methods in this paper. The Law on Environmental Protection 2020 has added "residential community" to the scope of regulation and application to affirm the position and role of this important target group in environmental protection as well as realizing one of the objectives. throughout the Law is to protect people's health, ensure people live in a healthy environment. For the community to participate effectively in environmental protection activities, information plays an important role.
Green Synthesis of Chitosan Nano Particles at Different Temperature for Bio-Medical Applications
Authors: Basumallick Srijita
Published: May 2023

Chitosan is a semi biopolymer obtained from natural biopolymer Chitin by depolymerisation and de-acetylation. It is bio-degradable, non-toxic and an ideal candidate for pharmaceutical uses. But major bottle-neck of biomedical application of chitosan is that it is insoluble in water therefore we have reported here preparation of ionically cross linked chitosan nano material using tartarate ion as ionic cross linker by greener hydrothermal technique at different temperature and pressure to regulate particle sizes. To the best of our knowledge this is the first time we are reporting hydrothermal synthesis of chitosan nanoparticles at high pressure to regulate particle sizes. Hydro- dynamic particle sizes have been determined by DLS measurement. We have also studied fluorescence behaviour of these chitosan nanoparticles and studied their anti-bacterial activities by Alamar assay on E Coli and S Aureus.
Computationally Efficient Thermal Management for Electric Vehicle
Authors: Ajishma C  , Arthi K  , Sneka K  , Soniya A  , George G Biju
Published: May 2023

The thermal management system, which is in charge of keeping the battery at the right temperature, uses a lot of power, especially when it comes to keeping the battery's temperature low. To get the most out of the vehicle's driving range, the batteries need to have the best temperature control systems possible. A model is used to describe the parts of a battery cooling system by showing how it uses energy and transfers heat. To make the modelling process easier, some assumptions are made. To make a stochastic model of future heat production that can be used in real time, it is important to include a probability distribution with gaps between the numbers. This is because the model needs to be right in order to work in real time. The proposed control method uses a lot less energy than other temperature sensors, like a thermostat or a model predictive controller that only uses data about what will happen in the future. This is done while keeping the temperature regulation performance at a good level. Even though the way the temperature is controlled hasn't changed in any way, this is still the case.
Evaluation of Herbal Formulation of Saaranai Chooranam Through Fourier Transform Infrared Spectroscopic Study
Authors: Sivalathajini Dr.S , Manoharan Dr.A , Umakalyani Dr.S
Published: May 2023

Background: The Siddha system of medicine is purely scientific and the peculiar complex system of science and philosophy. Fourier Transform Infrared Spectroscopy (FTIR) is certainly one of the most important analytical techniques for herbal medicine. FTIR can be implemented during herbal drug development in production for process monitoring or in quality control laboratories. Aim & Objective: The aim of study is to evaluate the morphology and elemental characterization of the Saaranai chooranam. The functional groups of their formulations are analysed through FTIR spectroscopy and the biological roles of the functional groups are discussed in this study. Materials and methods: The raw drugs is collected and purified as per Siddha literature. Drug Saaranai chooranam, which has been illustrated in the text Dr.S.Venkattarajan, Akasthiyar-2000, Part – III, Page: 102, for the management of Raththa Kothippu (Systemic Hypertension). Results: The Fourier Transform Infrared Spectroscopy compounds showed the presence of functional groups O-H Stretching (Alcohol), C-H Stretching (Alkane), O=C=O Stretching (Carbon dioxide), C-C bending (Alkene), O-H bending (Carboxylic acid), C-O Stretching (Aromatic ester), C-O Stretching (Tertiary alcohol), S=O Stretching (Sulfoxide), C-H bending (1,2-disubstituted) and C-1 Stretching (Halo compound) which ensures the therapeutic effect of the drug. Conclusion: The instrumental analysis FT-IRS study of Saaranai chooranam is the presence of functional groups through the stretch and bends which is responsible for its functional activity. The functional groups in Saaranai chooranam have diuretic and nervin tonic activities. This will ensure the efficacy and therapeutic effect of the drug.
THE IMPACTS OF ENERGY SUPPLY AND ENVIRONMENTAL TAXATION ON CARBON INTENSITY
Authors: Máté Domicián , Török László , Kiss Judit T.
Published: May 2023

Carbon dioxide (CO2) is a significant source of Greenhouse Gas (GHG) emissions and plays a crucial role in climate change and global warming. This study aims to explain the effects of primary and renewable energy supplies and environmental taxation and to analyse how taxation can alter their direct effects on carbon intensity. The research was conducted using a generalized method of moments model that uses instrumental variables with two-stage (2SGMM) estimators to calculate the direct and moderating effects of environmental taxes on carbon intensity. This study confirms the EKC theorem, and results have shown that primary energy supply and environmental-related taxation positively contribute to carbon intensity. The second finding indicates that a major increase in the proportion of renewable energy will greatly slow the rate of carbon dioxide emissions. The study provides additional evidence concerning the moderating role of taxation in amplifying the impacts of primary and renewable energy supply. The empirical findings suggest that the taxation impact is more fiscal than an incentive. In addition to the current energy and economic crisis, considerable funding and fiscal policies are needed to achieve more sustainable development paths towards carbon neutrality and energy security.
Deep Synoptic Array Science: Discovery of the Host Galaxy of FRB 20220912A
Authors: Ravi Vikram , Catha Morgan , Chen Ge , Connor Liam , Faber Jakob T. , Lamb James W. , Hallinan Gregg , Harnach Charlie , Hellbourg Greg , Hobbs Rick , Hodge David , Hodges Mark , Law Casey , Rasmussen Paul , Sharma Kritti , Sherman Myles B. , Shi Jun , Simard Dana , Squillace Reynier , Weinreb Sander , Woody David P. , Yadlapalli Nitika ,   The Deep Synoptic Array team, Ahumada Tomas , Dong Dillon , Fremling Christoffer , Huang Yuping , Karambelkar Viraj , Miller Jessie M.
Published: May 2023

We report the detection and interferometric localization of the repeating fast radio burst (FRB) source FRB 20220912A during commissioning observations with the Deep Synoptic Array (DSA-110). Two bursts were detected from FRB 20220912A, one each on 2022 October 18 and 2022 October 25. The best-fit position is (R.A. J2000, decl. J2000) = (23:09:04.9, +48:42:25.4), with a 90% confidence error ellipse with radii ±2″ and ±1″ in R.A. and decl., respectively. The two bursts are polarized, and we find a Faraday rotation measure that is consistent with the low value of +0.6 rad m−2 reported by CHIME/FRB. The DSA-110 localization overlaps with the galaxy PSO J347.2702+48.7066 at a redshift z = 0.0771, which we identify as the likely host. PSO J347.2702+48.7066 has a stellar mass of approximately 1010
M
⊙, modest internal dust extinction, and a star formation rate likely in excess of 0.1 M
⊙ yr−1. The host-galaxy contribution to the dispersion measure is likely ≲50 pc cm−3. The FRB 20220912A source is therefore likely viewed along a tenuous plasma column through the host galaxy.
A New LBV Candidate in M33
Authors: Martin John C. , Humphreys Roberta M. , Weis Kerstin , Bomans Dominik J.
Published: May 2023

The evolutionary relationships and mechanisms governing the behavior of the wide variety of luminous stars populating the upper H-R diagram are not well established. Luminous blue variables (LBVs) are particularly rare, with only a few dozen identified in the Milky Way and nearby galaxies. Since 2012, the Barber Observatory Luminous Stars Survey has monitored more than 100 luminous targets in M33, including M33C-4119 which has recently undergone photometric and spectroscopic changes consistent with an S Doradus eruption of an LBV.
ASSOCIATION OF POLYMORPHISM IN TICAM1 GENE WITH PROTECTION TO MODERATE/SEVERE COVID-19
Authors: Braga Matheus , E. Santiago Silva Pedro , H. U. Yamanaka Aléia , H. Souza Victor , Grava Sergio , F. Sela Ana , S. F. Neves Janisleya , Zacarias Joana , Jeane Eliete Laguila Visentainer Jeane
Published: May 2023

Clinical outcomes of Covid-19 have shown variability between individuals and populations. TICAM1 gene encodes the TRIFF protein, essential in the antiviral response, then the purpose of the study was to assess the effect of the polymorphism (rs2292151) G>A of TICAM1 gene on the severity of COVID-19 in individuals from the northern region of Paraná. A case-control study was performed, including patients, 100 mild and 50 moderate/severe Covid-19 cases, classified according to the WHO, by Hospital Paraná, Maringá, Brazil. The exclusion criteria used were: patients with heart disease, liver disease, other respiratory diseases, HIV, and cancer.The (rs2292151) G>A polymorphism was genotyped by qPCR and statistical analysis was performed using logistic regression in the SNPStats software. The genotype distribution was according to the expected in the Hardy-Weinberg equilibrium. There was an associationbetween the A/A genotype in a codominant model with protection against the severity of the disease (OR=0.14, 95% CI 0.03.-0.75, P = 0.01). The frequency of genotype A/A was 12% in mild cases and 4% in serious cases; the G/A was 44% in mild cases and 30% in serious cases, and the G/G was 44% in mild cases and 66% in serious cases. We can conclude that the A/A genotype (in a codominant genetic model) of the polymorphism (rs2292151) G>A was associated with a protection factor for moderate/severe Covid-19 in this population, however,the genotype determination should be done in a high number of patients.
CHRONIC EFFECT OF HYDROGYM IN PEOPLE WITH OBESITY AND CNCD POST-COVID: A PILOT STUDY
Authors: Aparecida de Souza Andressa , Gabriel da Silva Alexandrino Wesley , Regina de Sousa Thais , Jane dos Santos Pascoini Mara , Faúndez Casanova César , Nardo Junior Nelson
Published: May 2023

The objective of this study is to verify the effec of the practice of Hydrogymnastics as aregulatory factor for the treatment of obesity and post-COVID CNCDs. This is a descriptiveresearch with a comparative approach, carried out with individuals with obesity. A 16-weekIntervention program was applied, in which 40 volunteers participated, who were assigned toan Intervention Group (IG) and a Comparison Group (CG). The analysis was descriptivebetween pre and post test (GI= 26 and GC=14). Normality was contrasted for the totalsample, and by group (G1 and G2) for each of the measured variables. In the interventiongroup, some variables were maintained and did not change significantly, there wereimprovements only in DBP and HR. In the CG there were improvements only in the HRvariable, they also obtained improvements in weight, BMI, DBP and SBP, with a small effectsize. The Hydrogymnastic Training Program, performed in adults with obesity, in this studyshowed an improvement in the response of the double product: heart rate and systolic bloodpressure.
EFFECTS OF SWIMMING TRAINING IN OBESITY INSTALLATION IN ADULTS OFFSPRING BORN WITHIN A SMALL LITTER
Authors: Schumaker Siqueira Bruna , Valéria Fischer Stefani , Rocha Fujita Amanda , Grassiolli Sabrina
Published: May 2023

The excessive supply of energy during pregnancy and breastfeeding period, favors the highaccumulation of white adipose tissue (WAT) throughout life, commonly associated withinsulin resistance (IR), dyslipidemia and cardiovascular disease in adulthood. Chronic aerobicexercises reduce accumulation of WAT, preventing the development of metabolic diseases.On the 2 nd postnatal day, litter size was set to: normal (NL) with 9 pups per mother and small(SL) with 3 pups per mother, was used just male rats. After weaning (21 days), NL and SLrats, were divided into sedentary (Sed) and exercised (Exe), forming 4 experimentalsubgroups; NL Sed , NL Exe , SL Sed and SL Exe . From 22–90 days of life exercised groups performedswimming training 3 times for week during 30 minutes. Litter handling influenced bodyweight, retroperitoneal and mesenteric-WAT (p<0.0001) in adulthood. SL Sed animals showedan increase in these parameters when compared to NL Sed and NL Exe animals (P<0.0001).Swimming training reduced body weight and WAT deposits in NL and SL groups(P<0.0001). SL Sed and SL Exe animals showed elevated glucose values at 2h post-glucose loadwhen compared to NL animals. Kitt was also altered by litter reduction (P<0.0001), with SL Sedanimals had higher Kitt values compared to NL Sed and NL Exe rats. This response wasnormalized in SL Exe group.We conclude that lactational hypernutrition causes obesityassociated with disruption of glucose homeostasis and swimming training normalizes insulinsensitivity but is insufficient to restore glucose homeostasis during glucose tolerance test.
MATERNAL FOOD RESTRICTION DURING LACTATION LEADS TO SEX-SPECIFIC BLOOD HYPERTENSION AND CARDIAC REMODELING IN THE OFFSPRING
Authors: Valéria Naves Cavalcante Keilah , Divino Ferreira-Junior, Marcos , Penha Carvalho da Mota Ariel , Eduarda Ribeiro da Silva Maria , Antônio Barbosa Lima Sobrinho Jose , Mello Gomes Rodrigo , Rodrigues Pedrino Gustavo
Published: May 2023

Dietary restriction during pregnancy and puberty is a risk factor to hypertension onset atadulthood. The aim of this study was to evaluate the effect of maternal malnutrition duringlactation on cardiovascular parameters, in both sexes of rat pups at 120-day-old. Maternalfood restriction lead to arterial hypertension, baroreflex impairment, cardiac remodeling andincreased collagen deposition in the aorta, in adult male offspring. The females did not showfunctional or morphological disruptions. Together, these results show that maternal foodrestriction during lactation promotes cardiometabolic programming, generating cardiovascularalterations in male adult rat offspring, however female offspring present some kind ofcardioprotective effect.
EARLY GLYCOTOXIN EXPOSURE INDUCES EX-VIVO LEFT VENTRICULAR DYSFUNCTION IN ADULT RATS
Authors: P. C. Mota Ariel , E. R. Silva Maria , S. Rosa Isadora , A. B. L. Sobrinho Jose , D. Ferreira- Junior Marcos , V. N. Cavalcante Keilah , M. Costa Jaqueline , H. Castro Carlos , Matafome Paulo , M. Gomes Rodrigo
Published: May 2023

The exposure of the fetus/neonate to glycotoxins via the placenta or breast milk, such as themethylglyoxal (MG), has been related to short- and long-term disorders in its development.The aim of this study was to evaluate the effects of early exposure to methylglyoxal, duringthe lactation phase, on cardiac parameters at adulthood. All the experimental procedures wereapproved by the ethics committee of animal use of UFG (007/21). Eight pregnant rats wereseparated into: vehicle group (VEH); and MG group, MG (60 mg/kg), the treatment wascarried out from PN3 to PN14. The litters were standardized 4 male and 4 female pups. AtPN120, hearts were mounted in a Langendorff apparatus. 10’ of basal, 30’ ischemia and 30’of reperfusion were performed. Intraventricular systolic (ISP) and diastolic (IDP) pressure,dP/dt + and - were recorded. AUC of each experiment was calculated, and the results werecompared using two-way ANOVA with Sidak’s post-hoc test. Despite of no difference in theheart-to-body weight ratio, MG hearts presented reduced basal LV contractility in both male(p<0.01) and female (p<0.01) offspring. After ischemia, MG groups still presented decreasedLV contractility in both male and female offspring (p<0.05). Glycotoxins exposure during thelactation leads to reduced intrinsic contractility at adulthood and reduced chances of survivingischemic events.
NICOTINE EXPOSURE DURING BREASTFEEDING ALTERS CARDIAC PARAMETERS IN MALE AND FEMALE OFFSPRING
Authors: Carolina Rodrigues da Silveira Carla , Divino Ferreira-Junior Marcos , Valéria Naves Cavalcante Keilah , Penha Carvalho da Mota Ariel , Cristina Lisbôa da Silva Patrícia , Mello Gomes Rodrigo
Published: May 2023

Nicotine is one of the main psychoactive and toxic substances found in tobacco and itsexposure during the postnatal period can cause several damages to the health of the childduring intrauterine development and in adult life. The aim of this study was to evaluate theeffect of maternal postnatal nicotine exposure on cardiac parameters in adult rat offspring.Weight monitoring, echocardiography and organ collections were performed. In conclusion,offspring from mothers exposed to nicotine develops cardiac hypertrophy, further maleoffspring were more affected.
EARLY PPARα ACTIVATION PROTECT AGAINST HEPATIC MICROSTEATOSIS INDUCED BY POST-NATAL OVERFEEDING
Authors: L. M. Assakawa Ana , P. J. Saavedra Lucas , Raposo Scarlett , Lucredi Naiara , N. C. Peres Maria , Piovan Silvano , Gonçalves Gessica , Barbosa Letícia , Comar Jurandir , L. Almeida Douglas , C. F. Mathias Paulo
Published: May 2023

Post-natal overfeeding leads to development of obesity and metabolic dysfunction. PPARαactivation improves steatosis and metabolic dysfunction associated with obesity. Thus, wehave hypothesized that PPARα would prevent the metabolic disorders and obesity caused bylitter reduction. Wistar male offspring rats were divided into normal litter (NL - 9 pups) andsmall litter (SL - 3 pups) and were daily treated with an PPARα agonist, fenofibrate, frompost-natal day (PN) 1 until weaning (PN21), with either, fenofibrate (F - 12.5mg/kg) orvehicle (V). Forming the following groups: NL-V, NL-F, SL-V, SL-F. At PN120 animalswere euthanized and histological evaluation of samples from liver, visceral (VAT),subcutaneous (SAT) and brown (BAT) adipose tissue were performed. Fenofibrate was ableto prevent the development of microsteatosis in the liver caused by postnatal overfeeding. Inregard to VAT, there was no difference in the mean adipocyte area, however in distributionanalyzes it was observed higher frequency of larger adipocytes in SL groups, and nodifference was observed in SAT. SL-V animals had increased lipid area in BAT, which wasreduced in SL-F. Increased PPARα activation induced by an agonist during lactationimproved some histopathological abnormalities induced by postnatal overfeeding. This wasproven by the decrease in microsteatosis in the liver and improvement in VAT and BATmorphology, thus implying a better metabolic health.
EFFECT OF CHOLECALCIFEROL SUPPLEMENTATION ON HEPATIC STEATOSIS AND GLUCOSE IN OBESE ANIMALS
Authors: Mikuska Cordeiro Maiara , Silva Moreira Evelyn , Carolina Chagas Almeida Any , Paes Silva Beatriz , Indianara Bonetti Carla , Xavier Scomparin Dionízia , Fernando Comar Jurandir
Published: May 2023

Our proposal in this study is that with vitamin D supplementation in obese animals, there willbe reductions in hepatic steatosis and control of blood glucose levels. Male wistar rats wereused (CEUA nº 5866200720). After 21 days of age, they were acclimatized until they were 30days old, from this date on, the obesity induction protocol was initiated, by means of thecafeteria diet. The animals were divided into 2 groups: rats fed a normal diet [control group(CTL n= 24)] another with a hypercaloric diet [obesity induction group (WD n=24)]. After 90days old, they were subdivided into two other groups: CTL-VD (n=12) and WD-VD (n=12)animals in which, were supplemented with vitamin D3 (5.600UI/week, 90 to 130 days old, bygavage). At 131 days old, WD rats exhibited a significantly higher adiposity index than CTLand WD-VD rats. The WD-VD rats had a significantly lower adiposity index than WD rats.The hepatic steatosis was confirmed by biochemical measurements of the total liver lipidcontent increased in WD rats 5% of the liver weight. Vit D3 supplementation decreased BWgain, and reduction of the total lipid total liver in WD-VD rats. The glycemic curve wasperformed and the WD animals showed higher values ​​in the first 15 minutes than the CTLanimals. The WD-VD animals presented normal values ​​of the area under the curve, in relationto the WD. Vit D supplementation showed that there is a relationship between increasedadipose tissue and circulating vitamin D levels. Supplementation of VD3 attenuated hepaticsteatosis.
METHYLPHENIDATE EXPOSURE DURING PERIPUBERTAL PHASE AFFECTS LEARNING AND MEMORY OF ADULT RATS
Authors: Natália Chimirri Peres Maria , Y. Chinen Luana , R. Raposo Scarlett , N. S. Rodrigues Willian , L. Santos Filipe , Kian Guimarães Lopes Gabriel , Ferreira Barbosa Letícia , Ferreira Barbosa Letícia , Vinícius Martins Marcos , P. Lopes Rafael , Milani Humberto , Weffort de Oliveira Rubia , Cesar de Freitas Mathias Paulo , Palma- Rigo Kesia
Published: May 2023

Methylphenidate (MPH) is the active ingredient in Ritalin, although effective in treating ofthe attention deficit hyperactivity disorder (ADHD), its neurostimulation action is attractiveamong students in order to increase the focus or improving student performance. In context ofthe Developmental Origins of Health and Disease (DOHaD) concept, states that insults incritical phases of development, as the peripubertal period, may program the organism todysfunctions in adulthood. The aim of this work was to investigate the impact of peripubertalMPH exposure on learning and retrograde memory in adult rats. Male Wistar rats wereexposed to MPH (5 mg/kg) from post-natal day (PN) 30 until PN60 (MPH). Control animalsreceived 0.9% saline (Sal). At PN60, learning was evaluated true 10 days in an eight-armelevated maze and at PN120 retrograde memory. At PN60, MPH group showed a delay of61% in the latency, an increase of 100% in the number of errors and 200% in the number ofrepetition errors when compared to the Sal group, until the day 5 of learning period (p=0.004).After the washout period, at PN120, the MPH group showed an increase of 37% in thelatency, 49% in the number of errors of reference and 600% in the number of repetition errorscompared with the Sal group (p=0.001, p=0.004 and p=0.01). Exposure to MPH duringperipubertal phase decreases learning and memory in adult male Wistar rats.
METFORMIN DURING ADULTHOOD CANNOT ATTENUATE THE HARMFUL EFFECTS OF NEONATAL OVERNUTRITION
Authors: Pereira Lopes Rafael , Rodrigues Raposo Scarlett , Paulo Jacinto Saavedra Lucas , Vinícius Martins Marcos , Lomes da Cruz Kérolym , Ferreira Barbosa Letícia , Debossan Fernandes Maryana , Natália Chimirri Peres Maria , Narciso Mariana , Cezar de Freitas Mathias Paulo
Published: May 2023

Under- or overnutrition, during critical periods of development, lead to the development ofobesity and cardiometabolic dysfunction later in life in rats that have been programmed forthe development of metabolic dysfunction in a litter reduction model. On day 1, all litters arestandardized to 9 pups per dam and on day 3 after birth, litters were adjusted to 3 pups perdam in the small litter group (SL) and the NL group remained with 9 animals. At 70 days ofage, the animals were separated into 2 new groups: Saline (SAL) and Metformin (MET). For12 days, the NL and SL animals were treated daily with saline, giving rise to the NL-SAL andSL-SAL groups, or were treated with Met 100mg/kg/day, giving rise to the NL-MET and SL-MET groups. The treatment ended at 82 days of age and the animals were taken up to 142days of life. Body weight remained significantly higher in SL compared to NL animals up to142 days (p<0.0001), with no significant difference in relation to treatment. And the samewas observed in relation to glucose intolerance and insulin resistance (p<0.0001). We canconclude that short-term treatment with metformin did not attenuate the metabolicdysfunction induced by neonatal overnutrition.
EARLY METFORMIN TREATMENT IMPROVES GLUCOSE TOLERANCE IN OVERFED LACTATING RATS
Authors: A. Bobato Milene , V. G. Ribeiro Maiara , N. C. Peres Maria , P. J. Saavedra Lucas , Piovan Silvano , D. Gonçalves Gessica , N. S. Rodrigues William , R. Raposo Scarlett , Malta Ananda , C. F. Mathias Paulo
Published: May 2023

Metformin is the most widely used drug for the treatment of type 2 diabetes and metabolicdiseases worldwide. Lactation is understood as a sensitive phase of development capable ofprogramming the metabolism for health or disease in adult life. The aim of this study was toverify whether treatment with metformin during lactation could attenuate the metabolicdysfunctions in Wistar rats induced obesity by overfeeding during lactation. At birth, alllitters were adjusted to 9 pups (NL) for each mother and divided into two experimentalgroups: NL: Normal Litter Saline, NL-M: Normal Litter Metformin. Small Litter (SL) litterswere reduced to 3 pups per mother on the third day of life and were divided into twoexperimental groups: SL: Small Litter Saline and SL-M: Small Litter Metformin. Salina (S)pups received 0.9% saline solution from the first to the twelfth day of life via intraperitonealinjection. The other group received metformin (M) (100mg/kg of body weight (bw)/day) inthe same period of life. Early metformin treatment decreased body weight gain (BW) andfood intake (FI) in SL-M rats at 90 days old. The increase in retroperitoneal, mesenteric andgonadal fat reserves in SL animals not treated with metformin was shown to be reduced intreated SL animals. The intravenous glucose tolerance test showed greater tolerance in SL-M.We conclude that early treatment with metformin prevented BW gain and visceral adiposityin adult rats, caused by overfeeding during lactation, as well as improved glucose tolerance, aparameter also altered in small litter animals.