bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigation and Modeling for the Influence of Adding Date Press Cake on Drinkable Yogurt Quality
Authors: Alqahtani Nashi K. , Alnemr Tareq M. , Alsalem Abdullah K. , Alotaibi Mutlaq M. , Mohammed Maged
Published: March 2023

The extraction of date syrup produces a large quantity of by-product known as date press cake (DPC). This study aimed to utilize valuable ingredients of the DPC by adding 0 (Control), 2, 4, and 6% (g/100 g) of its powder to drinkable yogurt before fermentation. The physicochemical properties, texture profile, and sensory evaluation of the treated DPC-based drinkable yogurt (DPC drinkable yogurt) were measured after fermentation and 5, 10, and 15 days of storage at 4 °C. The modeling of the most critical quality attributes, i.e., pH, acidity, syneresis, water holding capacity (WHC), viscosity, and color difference (ΔE), was conducted to predict their values based on the DPC percentage and storage period. The DPC drinkable yogurt’s total solids, protein, and fat ranged between 11.19–11.83, 3.10–3.42, and 2.26–2.34%, respectively. Adding 2–6% DPC slightly increased the pH of DPC drinkable yogurt and decreased its acidity (p > 0.05) during storage. Increasing the DPC percent in DPC drinkable yogurt decreased the syneresis value, and WHC increased during storage. The color parameters and viscosity of DPC drinkable yogurt recorded the highest value at the end of the storage period for all treatments and increased steadily with the increase in DPC. The evaluation of the prediction models indicated that the predicted values were close to the actual experimental values for pH (R2 = 0.779), acidity (R2 = 0.973), syneresis (R2 = 0.961), WHC (R2 = 0.989), viscosity (R2 = 0.99), L* (R2 = 0.919), a* (R2 = 0.995), b* (R2 = 0.922), and ΔE (R2 = 0.921). The textural analysis indicated that increasing the concentration of DPC in the DPC drinkable yogurt increased hardness (g), springiness, cohesiveness, and gumminess and decreased adhesiveness and resilience during cold storage. The evaluation of sensory acceptance during the cold storage of the DPC drinkable yogurt was conducted by 30 expert panelists. Each panelist received four cups of 10 mL drinkable yogurt treatments at 5–10 °C. The evaluation results indicated that adding 2% of DPC was closest in overall sensory acceptability to the control sample (p < 0.05). This study revealed the potential use of DPC in drinkable yogurt as a natural, functional, and low-cost ingredient to improve the fiber content, physicochemical properties, and overall acceptability. Therefore, the fermented DPC-based yogurt drink has the potency to be a practical, value-added, and novel alternative to dairy-based yogurt.
Assessment of Nutritional Value and Maillard Reaction in Different Gluten-Free Pasta
Authors: Messia Maria Cristina , Cuomo Francesca , Quiquero Michela , Verardo Vito , Marconi Emanuele
Published: March 2023

Evaluating the nutritional quality and thermal damage effects of gluten-free foods is essential to ensure that people with gluten intolerance or celiac disease can safely meet their needs. In this work, fifteen different commercial gluten-free pasta samples made from cereals, pseudocereals, and pulses, alone or in mixed combinations, were analyzed to assess their nutritional value, essential amino acids composition, and protein chemical score. The occurrence of the Maillard reaction was investigated, and the levels of heat treatment markers (furosine, maltulose, hydroxymethylfurfural, and glucosylisomaltol) were determined. Analysis of the furosine values showed that pasta made with the same raw materials can have different degrees of thermal damage. There was no evidence of the Maillard reaction progressing in the advanced phase in any of the samples tested. Finally, the correlation between maltulose and furosine levels demonstrated the usefulness of combining the two markers to assess the extent of thermal damage.
Insights into Feruloylated Oligosaccharide Impact on Gel Properties of Oxidized Myofibrillar Proteins Based on the Changes in Their Spatial Structure
Authors: Yu Jingchao , Wang Shouwei , Sun Chengfeng , Zhao Bing
Published: March 2023

Polyphenolic compounds can protect against myofibrillar protein (MP) oxidation in meat products. In this study, the inhibitory effect of feruloyl oligosaccharides (FOs) on MP oxidation was investigated, and the gel properties of MPs were further studied. The results showed that 50–100 μmol/g protein of FOs could effectively inhibit damage to amino acid side chains by reducing carbonyl contents by 60.5% and increasing sulfhydryl and free amine contents by 89.5% and 66%, which may protect the secondary and tertiary structures of MPs. Additionally, FOs at 50 μmol/g protein had better effects on the crosslinking of MPs, leading to effective improvements in the gel properties, which can be seen in the rheology properties, scanning electron microscope (SEM) photographs, and the distribution of water in the MP gel. On the contrary, 150–200 μmol/g protein of FOs showed peroxidative effects on oxidatively stressed MPs, which were detrimental to MPs and contributed to their denaturation in the electrophoresis analysis and irregular aggregation in the SEM analysis. The concentration-dependent effects of FOs depended on MP-FOs interactions, indicating that an appropriate concentration of FOs has the potential to protect MPs from oxidation and enhance the gelation ability of pork meat during processing.
Bacteriological Quality and Biotoxin Profile of Ready-to-Eat Foods Vended in Lagos, Nigeria
Authors: Makinde Oluwadamilola M. , Sulyok Michael , Adeleke Rasheed A. , Krska Rudolf , Ezekiel Chibundu N.
Published: March 2023

A comprehensive study of bacterial and biotoxin contaminants of ready-to-eat (RTE) foods in Nigeria is yet to be reported. Hence, this study applied 16S rRNA gene sequencing and a dilute-and-shoot LC-MS/MS method to profile bacteria and biotoxins, respectively, in 199 RTE food samples comprising eko (n = 30), bread (n = 30), shawarma (n = 35), aadun (n = 35), biscuits (n = 34), and kokoro (n = 35). A total of 631 bacterial isolates, clustered into seven operational taxonomic units, namely Acinetobacter, Bacillus, Klebsiella, Proteus and Kosakonia, Kurthia, and Yokenella, that are reported for the first time were recovered from the foods. One hundred and eleven metabolites comprising mycotoxins and other fungal metabolites, phytoestrogenic phenols, phytotoxins, and bacterial metabolites were detected in the foods. Aflatoxins, fumonisins, and ochratoxins contaminated only the artisanal foods (aadun, eko, and kokoro), while deoxynivalenol and zearalenone were found in industrially-processed foods (biscuit, bread, and shawarma), and citrinin was present in all foods except eko. Mean aflatoxin (39.0 µg/kg) in artisanal foods exceeded the 10 µg/kg regulatory limit adopted in Nigeria by threefold. Routine surveillance, especially at the informal markets; food hygiene and safety education to food processors and handlers; and sourcing of high-quality raw materials are proposed to enhance RTE food quality and safeguard consumer health.
Control and Synchronization of a Novel Realizable Nonlinear Chaotic System
Authors: Almuzaini Mohammed , Alzahrani Abdullah
Published: March 2023

The study proposes a novel chaotic system with a cubic non-linear term. Different system characteristics are investigated including equilibria, stability, invariance, dissipation, Lyapunov dimension, and Lyapunov exponents. Also, the electronic circuit and Signal flow graph of the system are carried out to show the applicability of the chaotic system. Lyapunov stability theorem converts the system’s chaotic behavior to unstable trivial fixed point. The study also focuses on demonstrating complete synchronization between two similar novel chaotic systems. According to Lyapunov stability theorem, simple application in secure communication was developed by employing the chaos synchronization results. Numerical simulations for the systems are performed for establishing the synchronization strategy effectiveness and proposed control.
Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery
Authors: Alnaim Ahmed S. , Shah Hiral , Nair Anroop B. , Mewada Vivek , Patel Smit , Jacob Shery , Aldhubiab Bandar , Morsy Mohamed A. , Almuqbil Rashed M. , Shinu Pottathil , Shah Jigar
Published: March 2023

Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes have been extensively investigated as a transdermal vesicular nanocarrier to increase the delivery of low permeable compounds into and across the skin. This research work was to design, develop and optimize levosulpiride-loaded niosomal gel and to evaluate its prospects for transdermal delivery. The Box-Behnken design was used to optimize niosomes by analyzing the impact of three factors (cholesterol; X1, Span 40; X2, and sonication time; X3) on the responses (particle size, Y1, and entrapment efficiency, Y2). Optimized formulation (NC) was incorporated into gel and evaluated for pharmaceutical properties, drug release study, ex vivo permeation, and in vivo absorption. The design experiment data suggest that all three independent variables influence both response variables significantly (p < 0.01). Pharmaceutical characteristics of NC vesicles showed the absence of drug excipient interaction, nanosize (~102.2 nm), narrow distribution (~0.218), adequate zeta potential (−49.9 mV), and spherical shape, which are suitable for transdermal therapy. The levosulpiride release rates varied significantly (p < 0.01) between niosomal gel formulation and control. Greater flux (p < 0.01) was observed with levosulpiride-loaded niosomal gel than with control gel formulation. Indeed, the drug plasma profile of niosomal gel was significantly higher (p < 0.005), with ~3 folds higher Cmax and greater bioavailability (~500% higher; p < 0.0001) than its counterpart. Overall, these findings imply that the use of an optimized niosomal gel formulation can increase the therapeutic efficacy of levosulpiride and may represent a promising alternative to conventional therapy.
Bionic Aerogel with a Lotus Leaf-like Structure for Efficient Oil-Water Separation and Electromagnetic Interference Shielding
Authors: Liu Fengqi , Jiang Yonggang , Feng Junzong , Li Liangjun , Feng Jian
Published: March 2023

Increasing pollution from industrial wastewater containing oils or organic solvents poses a serious threat to both the environment and human health. Compared to complex chemical modifications, bionic aerogels with intrinsic hydrophobic properties exhibit better durability and are considered as ideal adsorbents for oil-water separation. However, the construction of biomimetic three-dimensional (3D) structures by simple methods is still a great challenge. Here, we prepared biomimetic superhydrophobic aerogels with lotus leaf-like structures by growing carbon coatings on Al2O3 nanorod-carbon nanotube hybrid backbones. Thanks to its multicomponent synergy and unique structure, this fascinating aerogel can be directly obtained through a simple conventional sol-gel and carbonization process. The aerogels exhibit excellent oil-water separation (22 g·g−1), recyclability (over 10 cycles) and dye adsorption properties (186.2 mg·g−1 for methylene blue). In addition, benefiting from the conductive porous structure, the aerogels also demonstrate outstanding electromagnetic interference (EMI) shielding capabilities (~40 dB in X-band). This work presents fresh insights for the preparation of multifunctional biomimetic aerogels.
Structuring of Cold Pressed Oils: Evaluation of the Physicochemical Characteristics and Microstructure of White Beeswax Oleogels
Authors: Ropciuc Sorina , Dranca Florina , Oroian Mircea Adrian , Leahu Ana , Codină Georgiana Gabriela , Prisacaru Ancuta Elena
Published: March 2023

The aim of the study was to characterize the gelling effect of beeswax (BW) using different types of cold pressed oil. The organogels were produced by hot mixing sunflower oil, olive oil, walnut oil, grape seed oil and hemp seed oil with 3%, 7% and 11% beeswax. Characterization of the oleogels was done using Fourier transform infrared spectroscopy (FTIR), the chemical and physical properties of the oleogels were determined, the oil binding capacity was estimated and the SEM morphology was studied. The color differences were highlighted by the CIE Lab color scale for evaluating the psychometric index of brightness (L*), components a and b. Beeswax showed excellent gelling capacity at 3% (w/w) of 99.73% for grape seed oil and a minimum capacity of 64.34%for hemp seed oil. The value of the peroxide index is strongly correlated with the oleogelator concentration. Scanning electron microscopy described the morphology of the oleogels in the form of overlapping structures of platelets similar in structure, but dependent on the percentage of oleogelator added. The use in the food industry of oleogels from cold-pressed vegetable oils with white beeswax is conditioned by the ability to imitate the properties of conventional fats.
Genetic and Clinical Characterization of Danish Achromatopsia Patients
Authors: Andersen Mette Kjøbæk Gundestrup , Bertelsen Mette , Grønskov Karen , Kohl Susanne , Kessel Line
Published: March 2023

Achromatopsia is a rare congenital condition with cone photoreceptor dysfunction causing color blindness, reduced vision, nystagmus and photophobia. New treatments are being developed, but the current evidence is still conflicting regarding possible progression over time, and there is no clear genotype-phenotype correlation. This natural history study aimed to further explore the course of disease and potential clinical differences between various genotypes. The retrospective design allowed for the study of a large cohort with a long follow-up. Patients were identified from the Danish national registries. If not already available, genetic analysis was offered to the patient. Clinical data from 1945–2022 were retrieved from medical records and included best-corrected visual acuity (BCVA), color vision, refractive error, nystagmus, visual fields and fundoscopic findings. We identified variants believed to be disease causing in five of the known achromatopsia genes: CNGA3; CNGB3; GNAT2; PDE6C and PDE6H; and novel variants were identified in CNGB3 and PDE6C. Progressive deterioration of BCVA only attributable to achromatopsia was found in three of 58 patients. Progressive phenotype was seen with variants in CNGB3 and PDE6C. The results indicate that myopia could be more frequently occurring with variants in GNAT2, PDE6C and PDE6H and support the evidence that achromatopsia is a predominantly stationary condition with respect to BCVA. Although a clear genotype-phenotype correlation can still not be concluded, there may be differences in phenotypical characteristics with variants in different genes.
Doxorubicin and Cisplatin Modulate miR-21, miR-106, miR-126, miR-155 and miR-199 Levels in MCF7, MDA-MB-231 and SK-BR-3 Cells That Makes Them Potential Elements of the DNA-Damaging Drug Treatment Response Monitoring in Breast Cancer Cells—A Preliminary Study
Authors: Mizielska Anna , Dziechciowska Iga , Szczepański Radosław , Cisek Małgorzata , Dąbrowska Małgorzata , Ślężak Jan , Kosmalska Izabela , Rymarczyk Marta , Wilkowska Klaudia , Jacczak Barbara , Totoń Ewa , Lisiak Natalia , Kopczyński Przemysław , Rubiś Błażej
Published: March 2023

One of the most innovative medical trends is personalized therapy, based on simple and reproducible methods that detect unique features of cancer cells. One of the good prognostic and diagnostic markers may be the miRNA family. Our work aimed to evaluate changes in selected miRNA levels in various breast cancer cell lines (MCF7, MDA-MB-231, SK-BR-3) treated with doxorubicin or cisplatin. The selection was based on literature data regarding the most commonly altered miRNAs in breast cancer (21-3p, 21-5p, 106a-5p, 126-3p, 126-5p, 155-3p, 155-5p, 199b-3p, 199b-5p, 335-3p, 335-5p). qPCR assessment revealed significant differences in the basal levels of some miRNAs in respective cell lines, with the most striking difference in miR-106a-5p, miR-335-5p and miR-335-3p—all of them were lowest in MCF7, while miR-153p was not detected in SK-BR-3. Additionally, different alterations of selected miRNAs were observed depending on the cell line and the drug. However, regardless of these variables, 21-3p/-5p, 106a, 126-3p, 155-3p and 199b-3p miRNAs were shown to respond either to doxorubicin or to cisplatin treatment. These miRNAs seem to be good candidates for markers of breast cancer cell response to doxorubicin or cisplatin. Especially since some earlier reports suggested their role in affecting pathways and expression of genes associated with the DNA-damage response. However, it must be emphasized that the preliminary study shows effects that may be highly related to the applied drug itself and its concentration. Thus, further examination, including human samples, is required.
Molecular Epidemiology and Diversity of SARS-CoV-2 in Ethiopia, 2020–2022
Authors: Sisay Abay , Tshiabuila Derek , van Wyk Stephanie , Tesfaye Abraham , Mboowa Gerald , Oyola Samuel O. , Tesema Sofonias Kifle , Baxter Cheryl , Martin Darren , Lessells Richard , Tegally Houriiyah , Moir Monika , Giandhari Jennifer , Pillay Sureshnee , Singh Lavanya , Ramphal Yajna , Maharaj Arisha , Pillay Yusasha , Maharaj Akhil , Naidoo Yeshnee , Ramphal Upasana , Chabuka Lucious , Wilkinson Eduan , de Oliveira Tulio , Desta Adey Feleke , San James E.
Published: March 2023

Ethiopia is the second most populous country in Africa and the sixth most affected by COVID-19 on the continent. Despite having experienced five infection waves, >499,000 cases, and ~7500 COVID-19-related deaths as of January 2023, there is still no detailed genomic epidemiological report on the introduction and spread of SARS-CoV-2 in Ethiopia. In this study, we reconstructed and elucidated the COVID-19 epidemic dynamics. Specifically, we investigated the introduction, local transmission, ongoing evolution, and spread of SARS-CoV-2 during the first four infection waves using 353 high-quality near-whole genomes sampled in Ethiopia. Our results show that whereas viral introductions seeded the first wave, subsequent waves were seeded by local transmission. The B.1.480 lineage emerged in the first wave and notably remained in circulation even after the emergence of the Alpha variant. The B.1.480 was outcompeted by the Delta variant. Notably, Ethiopia’s lack of local sequencing capacity was further limited by sporadic, uneven, and insufficient sampling that limited the incorporation of genomic epidemiology in the epidemic public health response in Ethiopia. These results highlight Ethiopia’s role in SARS-CoV-2 dissemination and the urgent need for balanced, near-real-time genomic sequencing.
Automating the Process for Estimating Tunneling Induced Ground Stability and Settlement
Authors: Shiau Jim , Sams Mathew , Arvin Mohammad Reza , Jongpradist Pornkasem
Published: March 2023

An automatic process for estimating ground stability and settlement of circular tunnels is developed for practitioners in this paper using finite difference method FLAC code. The numerical model aims to simulate the movement and relaxation of the soil around the shield and lining annulus that occurs due to the overcutting and grouting of the tunnel void by a tunnel boring machine. To achieve this, the model uses a pressure relaxation technique that progressively reduces the tunnel support pressure from the initial at rest condition until a point of failure is detected. At this stage, the stability number is calculated, and settlement data are exported for analysis. This is conducted for a range of geometry and soil ratios which cover most practical cases for cohesive soils. These stability numbers are then compared to rigorous upper and lower bound solutions. Using the settlement data, a trough width parameter ix is also determined for each case using regression of the commonly used Gaussian equation. The results of this study are quite positive, with the stability results from this study remaining within 5% of the upper and lower bound solutions; settlement results also compare well with previous experimental and observational results. The proposed automatic process can be used effectively and efficiently in most practical design projects.
A Semantic Cognition Contribution to Mood and Anxiety Disorder Pathophysiology
Authors: González-García Iván , Visser Maya
Published: March 2023

Over the last two decades, the functional role of the bilateral anterior temporal lobes (bATLs) has been receiving more attention. They have been associated with semantics and social concept processing, and are regarded as a core region for depression. In the past, the role of the ATL has often been overlooked in semantic models based on functional magnetic resonance imaging (fMRI) due to geometric distortions in the BOLD signal. However, previous work has unequivocally associated the bATLs with these higher-order cognitive functions following advances in neuroimaging techniques to overcome the geometric distortions. At the same time, the importance of the neural basis of conceptual knowledge in understanding mood disorders became apparent. Theoretical models of the neural basis of mood and anxiety disorders have been classically studied from the emotion perspective, without concentrating on conceptual processing. However, recent work suggests that the ATL, a brain region underlying conceptual knowledge, plays an essential role in mood and anxiety disorders. Patients with anxiety and depression often cope with self-blaming biases and guilt. The theory is that in order to experience guilt, the brain needs to access the related conceptual information via the ATL. This narrative review describes how aberrant interactions of the ATL with the fronto–limbic emotional system could underlie mood and anxiety disorders.
Reducing Violence in Riyadh’s Emergency Departments: The Critical Role of Healthcare Providers
Authors: Al-Wathinani Ahmed M. , Barten Dennis G. , Al-Balawi Halah , Al-Aqeel Sahar , Al-Dulijan Noora , Al-Ghamdi Khulood , Al-Shammari Sarah , Alhallaf Mohammad A. , Aljuaid Mohammad , Tin Derrick , Goniewicz Krzysztof
Published: March 2023

Emergency department staff are at high risk of experiencing violence and aggression from patients and visitors, which can have negative impacts on healthcare providers in the ED. The aim of this study was to explore the role of healthcare providers in addressing local violence in Riyadh EDs and investigate their preparedness for managing violent incidents. We used a descriptive, correlational design with survey methodology to collect data from a convenience sample of nurses, ED technicians, physicians, and advanced practice providers in Riyadh city’s EDs. To examine the associations, we used an analysis of variance (ANOVA) for unadjusted relationships and an analysis of covariance (ANCOVA) for adjusted associations. Measures included a demographic survey, and clinicians responded to an online survey. A total of 206 ED staff participated in the questionnaire, and 59% reported experiencing physical violence during an ED shift, with 61% of incidents being caused by relatives. Additionally, 32% of the participants witnessed workplace violence. Our findings revealed that male healthcare workers, physicians, and those working in the governmental sector were at the highest risk of experiencing violence. We also found a statistically significant association between the rate of patients seen in the ED and the frequency of assault (physical or verbal) in the ED. Our results suggest that the rate of workplace violence in Riyadh EDs is high, and more efforts are needed to protect the health and well-being of healthcare providers. Senior management should take a position against ED domestic violence and reinforce managerial and healthcare provider resources by adopting policies and procedures that protect healthcare workers’ safety. This study provides valuable insights into the nature and prevalence of violence in Riyadh EDs and highlights the critical role of healthcare providers in reducing violence in EDs.
Study Protocol on Social Return on Investment (SROI) Project of the Surgical Waiting List Management System
Authors: González Muñoz José Luis , García-Agua Soler Nuria , García Ruiz Antonio J.
Published: March 2023

In Andalusia, the right to maximum waiting times for healthcare clashes with the available supply, leading to an increase in demand in the form of waiting lists. To address this situation, the activity of private centers has been created for certain diagnostic tests. The Social Return on Investment (SROI) model evaluates an intervention from an economic and stakeholder perspective. However, there are no studies on the suitability of waiting lists using SROI, which is why it is intended to be studied as a decision-making tool for the clinical and healthcare management of waiting lists. This research protocol is designed to determine the quality of life gained, with the EuroQol-5D-5L questionnaire, and its social assessment, with the specific survey of the SROI method, and, thus, analyze the social return on investment and determine the suitability of the intervention (diagnostic endoscopy activity arranged in a contracted center). After the study, we will know the economic (cost in public health centers and the incremental cost of extraordinary health resources), social (quality of life with health), and environmental scenarios of the concerted activity intervention in order to adjust waiting list times.
Linking Learning Environment and Critical Thinking through Emotional Intelligence: A Cross-Sectional Study of Health Sciences Students
Authors: Christodoulakis Antonios , Kritsotakis George , Gkorezis Panagiotis , Sourtzi Panayota , Tsiligianni Ioanna
Published: March 2023

Background: Health sciences educators should increase the critical thinking of their students as this may improve the quality of care. However, this is rarely considered as a critical point in teaching, despite studies identifying factors such as the learning environment and emotional intelligence as increasing critical thinking at an undergraduate level. Thus, there is a need to better explore these factors and investigate interrelations and ways of improving critical thinking, especially in the critical field of healthcare students (nursing and medicine). Objectives: The present study aimed to examine the potential relationships between critical thinking with emotional intelligence and the learning environment. Method: This was a descriptive cross-sectional study with 208 first year health sciences university students of two nursing departments and one medicine department from three universities in Greece. The Critical Thinking Disposition Scale, Dundee Ready Education Environment Measure, and Trait Emotional Intelligence-Short Form questionnaires were used to assess critical thinking, the education environment, and emotional intelligence, respectively. Results: The results demonstrate that critical thinking was positively related to emotional intelligence (β = 0.82, p < 0.001), but not to the learning environment (β = 1.06, p = 0.30). However, a structural equation modeling analysis supported the indirect relationship between the learning environment and critical thinking through emotional intelligence (M = 1.10, CI = 0.13–2.17, p < 0.05). Conclusions: Emotional intelligence may be the underlying mechanism for achieving critical thinking if it is well applied and cultivated in a learning environment. Therefore, universities could modify their curricula and place emotional intelligence at the epicenter of teaching.
Dentistry and Gender Gap: An Overview of the Italian Situation
Authors: Bernardi Sara , Fulgenzi Maria Bruna , Rovera Angela , Rinaldi Fabiola , Trichilo Sara , Bianchi Serena
Published: March 2023

Recently, the issue of the gender gap in dentistry and in the leadership in the dental field has placed new challenges on dental profession representatives and politicians. Indeed, the inequity between genders in healthcare workforces represents a limit to the progression of those in the professions, inhibiting talented colleagues from accessing high positions in the academic world and not providing adequate role models to inspire future generations. The Italian population practicing dentistry in 2021 was composed of 74% males and 26% females. The aim of this study is to analyze the level of the gender gap in the dental field in Italy by focusing on the gender distribution of professional leaders in institutional category associations and invited speakers at dental conferences accredited for the Continue Education in Medicine program. The search strategy considered three different fields in the national dentistry scene: the dental committee boards, the union category associations, and the cultural field. The roles in the dental boards were retrieved from the website of the National Medical and Dental Committee from 2018 to 2022; the roles in the union category associations at the provincial, regional, and national levels were retrieved from the related web pages, considering the period from 2018 to 2021; and the information about the speakers at national conferences from 1 January 2019 to 31 December 2021 was retrieved from the National Agency for Regional Health Services (Agenzia nazionale per i servizi sanitari regionali (AGENAS)) websites. The extracted data were grouped and examined using descriptive statistics (frequency), and due to the categorical nature of the data, non-parametric tests (chi-square tests) were used to assess any differences between the two genders. The null hypothesis was that there were no statistical differences between the two genders’ distributions. A p-value was considered significant when <0.05. In addition, aiming to understand the representation of male and female dentists, a comparison of the distributions of males and females in the dental boards with the percentages of female and male dentists operating in Italy in 2021 was performed using a binomial test. The analysis of the data regarding the composition of the dental boards and of the union category association boards revealed a statistically significant difference in the distribution of the roles between the two genders at the regional and local levels, with a p-value of <0.05, and a significantly low representation of the women practicing dentistry (p < 0.05). In Italy, women practicing dentistry are underrepresented in dental organizations and in cultural events, given the low numbers of female dentists in leadership and/or speaker roles in the years 2018–2021. Even though the glass ceiling effect continues to affect Italian female dentists, initiatives and political measures have been taken to improve this condition and reach gender equity.
Evaluation of the Medical Resource Allocation: Evidence from China
Authors: Xi Yueming , Ding Ye , Cheng Yenuan , Zhao Junjie , Zhou Mengqiu , Qin Shangren
Published: March 2023

Medical resource allocation is an increasingly crucial issue. It is vital to understand residents’ (people living in the local area) evaluation of it. This study explores residents’ evaluation of medical resource allocation and its determinants with the dimensions of medical resource adequacy, balance, publicness, and accessibility. We used data from the China General Social Survey (CGSS). Binary logistic regression models were constructed from the four dimensions separately, and we compared the differences among them. The study’s results showed that accessibility and publicness are the highest and lowest dimensions of residents’ evaluation, respectively. The high evaluation of social equity may be a positive contributor to a higher evaluation of publicness and accessibility. The central region residents had the lowest evaluation of adequacy (OR = 0.697, p = 0.010) and balance (OR = 0.642, p = 0.008). To sum up, perceived social equity, social trust, and social class are crucial factors. Based on the results, the government should strengthen the supervision of the medical market, increase financial support for the health field in the central region, and establish a multi-level medical security system that may help optimize the allocation.
Trust in and Use of COVID-19 Information Sources Differs by Health Literacy among College Students
Authors: Chen Xuewei , McMaughan Darcy Jones , Li Ming , Kreps Gary L. , Ariati Jati , Han Ho , Rhoads Kelley E. , Mahaffey Carlos C. , Miller Bridget M.
Published: March 2023

People’s health information-seeking behaviors differ by their health literacy levels. This study assessed the relationship between health literacy and college students’ levels of trust in and use of a range of health information sources of COVID-19. We collected data from August to December 2020 among college students (n = 763) through an online survey. We used a health literacy measure containing three self-reported survey questions, developed by the CDC. We assessed the extent to which participants trusted and used any of the sixteen different sources of information about COVID-19. Respondents reported high levels of trusting and using COVID-19 information from the CDC, health care providers, the WHO, state/county/city health departments, and official government websites when compared to other sources. After controlling for demographic characteristics (i.e., gender, age, race, ethnicity, and income), those who reported having lower health literacy were significantly less likely to trust and use COVID-19 information from these health authorities when compared to participants who reported having higher health literacy. Students with lower self-reported health literacy indicated not trusting or using official health authority sources for COVID-19 information. Relying on low-quality information sources could create and reinforce people’s misperceptions regarding the virus, leading to low compliance with COVID-19-related public health measures and poor health outcomes.
The Impact of Race and Gender-Related Discrimination on the Psychological Distress Experienced by Junior Doctors in the UK: A Qualitative Secondary Data Analysis
Authors: Hussain Niha Mariam , Spiers Johanna , Kobab Farina , Riley Ruth
Published: March 2023

Almost half of NHS doctors are junior doctors, while high proportions are women and/or Black, Asian, and Minority Ethnic (BAME) individuals. Discrimination against this population is associated with poorer career-related outcomes and unequal representation. We aimed to qualitatively explore junior doctors’ experience of workplace racial and gender-based discrimination, and its impact on their psychological distress (PD). In this study, we carried out a secondary analysis of data from a UK-based parent study about junior doctors’ working cultures and conditions. Interview data was examined using thematic analysis. Transcripts (n = 14) documenting experiences of race and/or gender-based discrimination were sampled and analysed from 21 in-depth interviews conducted with UK junior doctors. Four themes were generated about the experiences and perpetrators of discrimination, the psychological impact of discrimination, and organisational interventions that tackle discrimination. Discrimination in various forms was reported, from racially charged threats to subtle microaggressions. Participants experienced profoundly elevated levels of PD, feeling fearful, undermined, and under-confident. Discrimination is associated with elevated levels of PD, whilst negatively impacting workforce sustainability and retention. This reduces the opportunity for more diversity in NHS medical leadership. We encourage NHS hospitals to review their policies about discrimination and develop in-person workshops that focus on recognising, challenging, and reporting workplace discrimination.
Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma
Authors: Carreras Joaquim , Kikuti Yara Yukie , Miyaoka Masashi , Hiraiwa Shinichiro , Tomita Sakura , Ikoma Haruka , Kondo Yusuke , Ito Atsushi , Nagase Shunsuke , Miura Hisanobu , Roncador Giovanna , Colomo Lluis , Hamoudi Rifat , Campo Elias , Nakamura Naoya
Published: March 2023

Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spindle-shaped cells with narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB) based on Hans’ classifier (CD10-negative, BCL6-positive, and MUM1-negative); EBER negativity, and the absence of BCL2, BCL6, and MYC rearrangements. Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in ACTB, ARID1B, DUSP2, DTX1, HLA-B, PTEN, and TNFRSF14. Based on the LymphGen 1.0 classification tool, this case had an ST2 subtype prediction. The immune microenvironment was characterized by moderate infiltration of M2-like tumor-associated macrophages (TMAs) with positivity of CD163, CSF1R, CD85A (LILRB3), and PD-L1; moderate PD-1 positive T cells, and low FOXP3 regulatory T lymphocytes (Tregs). Immunohistochemical expression of PTX3 and TNFRSF14 was absent. Interestingly, the lymphoma cells were positive for HLA-DP-DR, IL-10, and RGS1, which are markers associated with poor prognosis in DLBCL. The patient was treated with R-CHOP therapy, and achieved a metabolically complete response.
Production Technologies and Provenance of Ceramic Materials from the Earliest Foundry of Pre-Roman Padua, NE Italy
Authors: Pérez-Monserrat Elena Mercedes , Maritan Lara , Baratella Vanessa , Vidale Massimo
Published: March 2023

The earliest foundry site of Pre-Roman Padua, in the Veneto region (north-eastern Italy), provided evidence of craft activities and residential areas dated between the end of the 9th and 1st centuries BCE. Common and fine wares were found, most of them belonging to two main ceramic classes: (i) highly dark-colored bodies with silicate inclusions; (ii) carbonate-tempered pots. Macroscopic and petrographic (POM) descriptions and spectroscopy—mineralogical (XRPD) and geochemical (XRF)—analyses were carried out to define the provenance and technological choices (production recipes and firing conditions). The first ceramic class comprised diverse local/regional productions made with a common geo-resource, consisting in quartz-rich illitic clays, for which pit firing conditions generally under 850–900 °C were adopted. The purification of the starting base clays, the tempering of the clayey pastes with silica-rich grains and/or the polishing of surfaces were accomplished for fine wares. The carbonate-tempered pottery probably corresponded to an allochthonous ceramic class that might be used in the trade of specific contents. As such pots were made out of different illitic clays and under different redox conditions, they might correspond to diverse productions. The adoption of precise choices in very specific wares, not belonging to any of these two main ceramic classes, suggests the trade of fine wares in the Veneto during the First Iron Age.
Wine Hotels—Intangible Heritage, Storytelling and Co-Creation in Specific Tourism Offer
Authors: Floričić Tamara , Jurica Ketrin
Published: March 2023

This paper researches aspects of affirmation of intangible heritage and the valorisation of viniculture through themed wine hotels that offer integral wine experiences as well as satisfy tourists’ needs for individualism. This paper aims to explore the intangible cultural heritage through thematic wine hotels and identify special tourism products and experiences created via storytelling and co-creation that impact its competitiveness. The research design includes the selection process of wine hotels in the international context, a comparative analysis of themed hotel offers online promotions, and original research of themed offers. Data is analysed using qualitative and quantitative methodology, including statistical processing. Developed under the concept of wine tourism, themed accommodation facilities—wine hotels—are the core value in the creation of an integral wine experience. However, the research results indicate that international wine hotels do not affirm all the potential and possibilities of creating specific products and do not realise their full competitiveness. The results form a platform for the proposal of a competitiveness model, which synergically affirms hotel core competencies, expressed through tangible and intangible features, sustainability, experiences, co-creation, special advantages and marketing mix elements. Recommendations for wine hotels’ new competitiveness represent an additional contribution of the paper and point to new considerations directed towards innovations, creativity and affirmation of intangible heritage.
Color and Light: A Hellenistic Terracotta Figurine of a Maenad from Myrina
Authors: Bourgeois Brigitte , Verri Giovanni , Jeammet Violaine
Published: March 2023

During the Hellenistic period and under the growing influence of the art of painting, the polychromy of Greek terracotta figurines focused not only on an elaborate rendering of color, but also on the interplay of light and shadow. Some of the best-preserved examples clearly show the subtlety of such pictorial effects. Among them is a statuette of a standing Maenad, held in the collections of the National Archaeological Museum in Athens (inv. 5000). Dating back to 150–100 BCE, it is a high-quality testament to the sculptural, as well as pictorial, coroplastic production in the workshops of Myrina (Eolide, Turkey). Combining multi-scale examination, multi-spectral imaging and non-invasive spectroscopic investigations (XRF, FTIR, FORS), a scientific study of the artefact was carried out within the framework of the Pilina project, a collaborative research program between the Louvre, the C2RMF, the National Archaeological Museum and the French School in Athens. This article presents the main results of the study by discussing the color scheme, identification of some pigments and colorants (clays of the kaolinite group, ochres, cinnabar, Egyptian blue, an anthraquinone of plant origin, likely madder, gold leaf), and painting techniques aiming at achieving chiaroscuro effects.
Development and Intervention Proposal with Earthen Refurbishments with Vegetal Origin Gel (VOG) for the Preservation of Traditional Adobe Buildings
Authors: González-Sánchez B. , Sandoval-Castro K. , Navarro-Ezquerra A. , Ramírez-Casas J. , Sanchez-Calvillo A. , Alonso-Guzmán E. M. , Navarro-Mendoza E. G.
Published: March 2023

This research focuses on the addition of an ecological, sustainable material to improve the durability of earthen constructions and for use in rehabilitation and restoration processes. Specifically, it studies the mechanical and waterproof performance of an earthen mixture with the addition of a vegetal origin gel (VOG) obtained by extracting the starch contained in rice. This solution increases the durability of the mixture and the behavior against water and improves the mechanical resistance of the system. This study is divided into two parts. First, an experimental phase was carried out in the Universitat Politècnica de Catalunya laboratory to design and develop the earthen mixtures stabilized with VOG to obtain an ecological, economical and easily replicable technology that can be transferred to any population group. The second stage consisted of the application of these mixtures and a real intervention in adobe dwellings in the community of Santa Ana Chapitiro, in the State of Michoacan, Mexico. The rehabilitation solutions and dosages were transferred to the residents of the community and applied to local adobe constructions by means of participatory design through an international development cooperation project. Good behavior of the material was found in the early stage.
Competency-Based Assessment Practices in Higher Education: Lessons from the Pandemics
Authors: Cano Elena , Lluch Laia , Grané Mariona , Remesal Ana
Published: March 2023

This article reports on a research project on university teaching and learning in the context of pandemics. Sixteen university professors and fifteen bachelor’s degree students were interviewed regarding “emergency e-assessment practices” during the first lockdown semester at a Spanish institution. The research aimed to understand their perception of how generic competencies were being assessed. Data were generated in semi-structured individual interviews. The main findings are: (a) generic competencies are not explicitly considered in e-assessment practices; (b) online assessment practices follow mainly a summative purpose; (c) digital technologies are not considered for the instructional design; (d) both instructors and students lack assessment literacy. Furthermore, there are difficulties in reaching a shared understanding regarding what competency-based assessment means and its implications for daily praxis. The results underline the challenge of using digital technologies for fostering and assessing generic competencies, as well as the need for assessment literacy on both sides, teachers and students.
Studies on the Molecular Basis of Heterosis in Arabidopsis thaliana and Vegetable Crops
Authors: Shiraki Saaya , Fujiwara Kazumasa , Kamiya Yoshiki , Akter Mst. Arjina , Dennis Elizabeth S. , Fujimoto Ryo , Mehraj Hasan
Published: March 2023

Heterosis is an important phenomenon for high-yield crop breeding and is utilized for breeding F1 varieties in horticultural crops. However, its molecular mechanism has not been elucidated, and compared to cereals, heterosis is less explored at the molecular level in horticultural crops. In this review, we compiled the new genetic and epigenetic studies on heterosis in horticultural crops. Because of the difficulty of predicting the level of heterosis from the parental genetic distance, molecular approaches are being used to study its molecular basis in horticultural crops. Transcriptome analyses in vegetables have identified photosynthesis-related genes as important in heterosis. Analysis of noncoding RNAs has suggested their involvement in regulating the heterosis of vegetative and fruit tissues. Quantitative trait locus (QTL) analysis has revealed the association of heterozygosity of a specific locus or multiple loci with heterosis of vegetative and fruit tissues. A higher level of DNA methylation was noted in the heterotic F1 of Brassica rapa leafy vegetables, while the roles of other epigenetic modifications such as histone marks have not been explored.