bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da aprendizagem matemática no primeiro ano do Ensino Médio de uma escola da rede pública estadual de Mato Grosso: entre a teoria e a realidade
Authors: Marchiori Sandra Terezinha , Darsie Marta Maria Pontin
Published: October 2021

Este artigo apresenta resultados de uma pesquisa que tem como objeto a avaliação da aprendizagem na matemática. A questão central é compreender como a avaliação está sendo concebida e praticada por professores das turmas do primeiro ano do Ensino Médio. Para isso, buscou-se analisar o processo avaliativo apresentado nos documentos oficias que orientam a Educação Básica no Brasil e em Mato Grosso (MT) e conhecer a concepção e a prática de avaliação da aprendizagem dos docentes desta etapa. A pesquisa foi desenvolvida em uma Escola Estadual do Município de Sinop/ MT, envolvendo três professores de Matemática. A análise e interpretação dos dados produzidos se desenvolveram à luz dos princípios norteadores da avaliação formativa, conforme as acepções epistemológicas de Luckesi (2011; 2018), Perrenoud (1999), Darsie (1998), Hoffmann (2018), Sacristán e Gómez (1998) e Libâneo (2006). Optou-se pela pesquisa qualitativa exploratória com análise interpretativa de documentos oficiais e dos dados gerados junto aos professores tendo questionário e entrevista como instrumento de investigação. Tal instrumento objetivou verificar de que forma os docentes de Matemática percebem os estudantes ingressantes no Ensino Médio nos seguintes aspectos: postura diante do estudo e conhecimento matemático básico construído no Ensino Fundamental. Em acréscimo, como esses saberes são diagnosticados e avaliados, pelos professores, durante o ano letivo. Nessa conjectura, os resultados apontaram uma ruptura no processo de ensino e no formato de avaliação na passagem do Ensino Fundamental (Ciclo de Formação Humana) para o Ensino Médio (seriado), fator que incide no desempenho do aluno.
Efeitos e Aplicações do Campo Eletromagnético de Alta Intensidade (PEMF) em saúde e estética: perspectivas e evidências clínicas
Authors: Martins Rodrigo Alvaro Lopes , Matias Michele , Bueno Felícia Cadenas de Paiva , Oguri Mayara , Leonardo Patricia Sardinha , Ruiz-Silva Carlos
Published: October 2021

The increased interest and concern with physical fitness, not only from an athletic point of view, but also from an aesthetic point of view, has driven the search for new methods and technologies capable of helping to gain mass and muscle tone. Recent studies show that 81% percent of respondents reported dissatisfaction with their body image, even with 56% having a normal body mass index. Pulsed electromagnetic field (PEMF) muscle stimulation technology uses alternating magnetic fields based on the law of electromagnetic induction to promote supramaximal muscle contractions. PEMF generates impulses that are independent of brain function, and with such a fast frequency that it does not allow the muscle relaxation phase, characterizing tetanic contractions. Electric currents and electromagnetism have been used in physical therapy and rehabilitation, especially for muscle strengthening. However, the PEMF technology has emerged as a more efficient and comfortable alternative for the patient, with the primary objective of toning and strengthening muscle groups. In this work, we performed a literature review of all scientific articles available and indexed in Pubmed and Web of Science about this technology in the last 20 years and its effects on skeletal muscles. We discuss the scientific evidence available from clinical studies and discuss effects and possible mechanisms of action on muscle contraction.
Desempenho agronômico de forrageiras tropicais
Authors: Reis Renata Vilalba , Rocha Rosana Andréia Silva , Santos Deborah de Amorim Teixeira , Búfalo Veridiana Camila Ferreira
Published: October 2021

As gramíneas constituem a base da alimentação para bovinos de corte e leite, e devido a sua grande importância, é necessário escolher cultivares adaptadas a diversas condições edafoclimáticas, tendo em vista a ampla extensão territorial do Brasil. Dessa forma, objetivou-se com esse estudo, avaliar a produção bruta, produção de matéria verde, taxa de acúmulo e altura de planta de duas forrageiras tropicais. Para isso, foi conduzido um experimento a campo, em uma área de pastagem, localizado em uma propriedade no município de Nova Maringá, Estado de Mato Grosso. O experimento foi conduzido por delineamento experimental em blocos casualizados (DBC) com dois tratamentos, sendo: a cultivar Piatã (Urochloa brizantha) e a cultivar Zuri (Megathyrsus maximus) e 10 repetições, totalizando 20 parcelas. A unidade experimental, foi representada por uma área total de 0,7 ha. As variáveis avaliadas foram produção bruta, produção de matéria verde, taxa de acúmulo e altura de planta. A coleta dos dados foi realizada 100 dias após a emergência. A gramínea do gênero de Megathyrsus maximus cultivar Zuri, possuem grande potencial para a produtividade, e a cultivar Piatã, apresentou resultados não tão satisfatório. Porém, cada cultivar dispõem de características próprias, e se comporta de formas diferentes onde são cultivadas.
Invasive cervical resorption: case report
Authors: Rodrigues Matheus Almeida , Silva Marcely Reis da , Carvalho Adolfo de Matos de , Souza Caio Cesar , Rosas Cesar Augusto Perini , Cardoso Ryhan Menezes , Limoeiro Ana Grasiela da Silva
Published: October 2021

Invasive cervical resorption (ICR) is an insidious, aggressive, and asymptomatic form that can lead to destruction and even loss of the dental unit. ICR is somewhat uncommon, but it can affect any tooth, with the maxillary central incisors being the most affected. Even after numerous studies, the etiology is still unclear. There are some predisposing factors, including orthodontic treatment, trauma, and internal tooth whitening, which may occur in isolation or in conjunction with each other. This article reports a clinical case of ICR class 3 with a rosy discoloration at the cervical margin and the presence of a fistula associated with a history of trauma. This suspicion was raised after radiographic examination and confirmed by cone-beam computed tomography (CBCT), with treatment via an internal approach and endodontic treatment involving debridement of the resorptive areas and filling with a bioceramic repair material and suturing. After treatment, the patient remained asymptomatic, but the fistula was no longer present. Prospective observation at 10 months showed bone formation in the middle third and well-adapted material in the cervical region, with no resorptive tissue present.
Reabilitação dental com retentor intrarradicular - relato de caso clínico
Authors: Palheta Sandreani da Silva , Silva Géssica Vasconcelos da , Lima Thiago Mendes de
Published: October 2021

Objetivo: O presente estudo relata um caso clínico de reabilitação do incisivo central superior esquerdo com uso de retentor intrarradicular pino de fibra de vidro, utilizando a técnica do pino anatômico com resina composta. Metodologia: Trara-se de um relato de caso clínico de cunho analítico descritivo (Pereira et al., 2018), realizado na clínica odontológica do CEUNI-Fametro, na disciplina de estágio supervisionado em Clínica Integrada II. Relato de caso clínico: A paciente melanoderma, R. R, de 43 anos, procurou atendimento, tendo como queixa principal o comprometimento da aparência estética do dente 21; relatou que comprometia seu sorriso e o incomodo. Nos exames clínico e radiográfico observou-se extensa destruição coronária e tratamento endodôntico insatisfatório. Foi planejado e realizado o retratamento endodôntico e a reabilitação com uso de retentor pré-fabricado pino de fibra de vidro. O pino de fibra de vidro foi condicionado com ácido fosfórico para limpeza da superfície, lavado com spray de ar e água, feito a secagem, preparado com silano, sistema adesivo e fotopolimerização. A resina composta foi depositada sobre o pino, levando ao conduto este lubrificado com gel hidrossolúvel, fazendo movimento de inserção e remoção, modelando o formato do conduto radicular. O cimento resinoso utilizado foi autoadesivo dual. A restauração da coroa clínica com resina composta com a técnica direta utilizando o protocolo de preparo para faceta e estratificação de cor. Considerações finais: O uso do pino de fibra de vidro mostrou-se uma alternativa eficaz na reabilitação do dente, favorecendo a estética da paciente, obtendo um resultado satisfatório.
Efeitos do agulhamento a seco no tratamento dos pontos-gatilho na síndrome dolorosa miofascial na coluna cervical: uma revisão sistemática de ensaios clínicos randomizados
Authors: Silva Jéssica dos Santos , Cunha Gisele da Silva , Marques Bruna Caroline dos Santos , Silva Wanderson Fernandes
Published: October 2021

A síndrome dolorosa miofascial é uma das causas mais comuns de dor musculoesquelética e incapacidade acometendo uma faixa etária entre 31 e 50 anos, sendo mais propícia em pessoas que realizam movimentos repetitivos e com mais frequência na região cervical e cintura escapular. A etiologia exata da síndrome dolorosa miofascial não é totalmente definida porem seu tratamento é focado em diminuir a dor, melhorar a força muscular e proporcionar uma boa postura. O agulhamento a seco e um procedimento pouco invasivo, tendo por objetivo reduzir o quadro de dor miofascial ao colocar uma agulha diretamente sobre o ponto-gatilho e com a finalidade de provocar diminuição da dor local, além de restaurar a amplitude de movimento. Foi realizada uma revisão sistemática de ensaios clínicos randomizados, que tem por objetivo identificar os benefícios do agulhamento a seco na coluna cervical para pacientes com síndrome dolorosa miofascial através de uma revisão sistemática da literatura. Foram utilizadas as seguintes bases de dados: PEDro, ScieLo e Pubmed, nos idiomas português e inglês entre 2016 a 2021. Foram obtidos 552 estudos, após o cruzamento dos descritores e aplicação dos critérios de inclusão e exclusão, foram selecionados 10 artigos. O agulhamento a seco é um tratamento de grande valia para pacientes com síndrome de dor miofascial na coluna cervical, melhorando a dor. Porém, a combinação de outras técnicas produz relaxamento muscular, amplitude de movimento dos músculos cervicais refletindo na qualidade de vida destes pacientes.
Prevalência de cervicalgia em estudantes universitários: uma revisão integrativa
Authors: Sousa Ana Karoline Correa , Silva Dhuly Ramos da , Sousa Diego Sarmento de
Published: October 2021

Introdução: A cervicalgia é considerada uma afecção bastante comum atualmente. Afeta cerca de 50% de toda a população, com predominância no sexo feminino. No contexto acadêmico, o acumulo de tarefas exigidas, o tempo destinados aos estudos e a postura em flexão cervical relacionada ao uso de smartphones e computadores, aumentam a probabilidade de ocorrer disfunções musculoesquelética na região cervical. Objetivo: Conhecer a prevalência de cervicalgia em estudantes universitários e seus fatores associados. Metodologia: as bases de dados escolhidas para a realização desta pesquisa foram: PubMed, Science Direct, e Google acadêmico. Foram incluídos artigos publicados no período de 2017 a 2021, nos idiomas português e inglês, cujo título, descritores ou resumo fizessem referência a temática. Como critérios de exclusão: artigos que não encontrados na íntegra, revisão simples de literatura e aqueles que não respondessem a proposta do estudo. Resultados e Discussão: Dentre os períodos pesquisados seis são internacionais e quatro nacionais, o que representa escassez de estudos brasileiros acerca dessa temática. A maioria dos dados constataram prevalência significante de cervicalgia em estudantes universitários. Conclusão: Subsiste uma prevalência relevante de cervicalgia em estudantes universitários que tem afetado diretamente à qualidade de vida.
Post-hoc analysis on the cd14 c(-260)t promoter polymorphism and coronary heart disease
Authors: Porsch-Özcürümez M , Hucke J , Westphal S , Hubáček JA , Schmitz G , Luley C
Published: October 2021

Functional C(-260)--> T polymorphism in the promoter of the CD14 gene has been reported to be associated with coronary heart disease (CHD). The functional role of the polymorphism, however, is still a matter of debate, since several studies have not proved its effect on clinical outcomes associated with atherosclerosis. Cardiovascular-related morbidity and mortality was assessed in a post-hoc approach four years after baseline characterization of patients (male/female n = 36/32) with angiographically proven coronary heart disease. CD14 C(-260)--> T promoter genotype was determined at baseline. Seventeen out of 20 CHD patients with non-lethal cardiovascular events carried at least one T-allele. CD14 T-260 allele carriers have a 3.59-fold (95 % confidence interval: 1.11-6.75) increased risk for non-lethal cardiovascular events (Kaplan-Meier plot: log rank test p = 0.029). All patients with lethal outcomes (n = 6) were also T-allele carriers. Multivariate logistic regression analysis among CHD patients including age, established risk factors and the C(-260)--> T polymorphism as covariates and non-lethal events as a dependent variable confirmed the independent prospective effect of the T-allele on cardiovascular outcomes in this subset. Further evidence is provided for the role of CD14 C(-260)--> T promoter polymorphism as a genetic susceptibility marker of atherosclerosis in patients with an advanced clinical course of the disease. Due to the small sample size and post-hoc character of the study large-scale prospective studies that monitor patients with proven CHD are needed to confirm these findings.
Effects of rate of decrease in power output in decrement-load exercise on oxygen uptake
Authors: Yano T , Yunoki T , Matsuura R , Arimitsu T , Kimura T
Published: October 2021

The purpose of this study was to examine how oxygen uptake (Vo2) in decrement-load exercise (DLE) is affected by changing rate of decrease in power output. DLE was performed at three different rates of decrease in power output (10, 20 and 30 watts.min(-1): DLE10, DLE20 and DLE30, respectively) from power output corresponding to 90 % of peak Vo2. Vo2 exponentially increased and then decreased, and the rate of its decrease was reduced at low power output. The values of Vo2 in the three DLE tests were not different for the first 2 min despite the difference in power output. The relationship between Vo2 and power output below 50 watts was obtained as a slope to estimate excessive Vo2 (ex-Vo2) above 50 watts. The slopes were 10.0+/-0.9 for DLE10, 9.9+/-0.7 for DLE20 and 10.2+/-1.0 ml.min(-1).watt(-1) for DLE30. The difference between Vo2 estimated from the slope and measured Vo2 was defined as ex-Vo2. The peak value of ex-Vo2 for DLE10 (189+/-116 ml.min(-1)) was significantly greater than those for DLE20 and for DLE30 (93+/-97 and 88+/-34 ml.min(-1)). The difference between Vo2 in DLE and that in incremental-load exercise (ILE) below 50 watts (DeltaVo2) was greater in DLE30 and smallest in DLE10. There were significant differences in DeltaVo2 among the three DLE tests. The values of DeltaVo2 at 30 watts were 283+/-152 for DLE10, 413+/-136 for DLE20 and 483+/-187 ml.min(-1) for DLE30. Thus, a faster rate of decrease in power output resulted in no change of Vo2 at the onset of DLE, smaller ex-Vo2 and greater DeltaVo2. These results suggest that Vo2 is disposed in parallel in each motor unit released from power output or recruited in DLE.
Renal adrenomedullin and high altitude diuresis
Authors: Haditsch B , Roessler A , Hinghofer-Szalkay HG
Published: October 2021

Previous investigations revealed that most of the fluid regulating hormones showed no consistent relationship to the hypoxic diuretic response (HDR). In this study we examined if adrenomedullin (AM), a hypoxia-mediated diuretic/natriuretic peptide is connected to HDR. Thirty-three persons were examined at low altitude (LA), on the third exposure day at 3440 m (medium altitude, MA) and on the fourteenth day at 5050 m (high altitude, HA). Nocturnal diuresis rose from 460 ml [interquartile range 302 ml] at LA to 560 [660] ml at MA to 1015 [750] ml at HA (p<0.005). Sodium excretion was similar at LA and MA (41.8 [27.0] vs. 41.4 [28.4] mM) and increased to 80.2 [29.1] mM at HA (p<0.005). Urinary AM excretion was 7.9 [3.9] at LA, 7.5 [5.7] pM at MA, and increased to 10.5 [5.1] pM (p<0.05) at HA. Urinary AM excretion was correlated to diuresis (r=0.72, p<0.005) and sodium excretion (r=0.57, p<0.005). Plasma AM concentration rose from 16.4 [3.1] to 18.8 [4.9] pM/l at MA (p<0.005) and to 18.3 [4.3] pM/l at HA (p<0.005). Plasma AM concentration and urinary AM excretion were not correlated, neither were plasma AM concentration and diuresis or natriuresis. Our data suggest the involvement of increased renal AM production in the pathophysiology of high altitude fluid and sodium loss.
The role of tissue factor in thrombosis and hemostasis
Authors: Malý MA , Tomašov P , Hájek P , Blaško P , Hrachovinová I , Salaj P , Veselka J
Published: October 2021

The tissue factor (TF) is one of the most important regulators of arterial thrombosis. Because arterial thrombosis is the pathophysiologic background of acute coronary syndrome, the possible impact of blocking the arterial thrombosis on its onset is a challenging problem. The investigations of TF brought a new concept of "cell-based coagulation model" which highlighted the question of blood-borne TF as a source of TF in circulating blood. In this review we summarize essential information on the pathophysiology, molecular structure, expression and distribution of TF and we propose a novel concept of blood-borne TF, suggesting the possibilities of inhibition of the coagulation cascade with newly synthetized drugs.
Effect of PPAR-γ agonist treatment on markers of endothelial dysfunction in patients with type 2 diabetes mellitus
Authors: Doležalová R , Haluzík MM , Bošanská L , Lacinová Z , Štulc T , Haluzík M
Published: October 2021

Thiazolidinediones are insulin-sensitizing drugs acting through peroxisome proliferator-activated receptor (PPAR)-gamma. The aim of our study was to evaluate the effect of 5-month treatment with PPAR-gamma agonist--rosiglitazone (4 mg/day), on the circulating markers of endothelial dysfunction and to evaluate the role of changes in endocrine function of adipose tissue in this process. Biochemical and metabolic parameters, circulating adiponectin, resistin, ICAM-1, VCAM-1, E-selectin, P-selectin, PAI-1, myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9) concentrations were assessed in 10 women with type 2 DM before and after rosiglitazone treatment and in a control group of healthy women. At baseline, diabetic group had significantly higher serum concentrations of glucose, glycated hemoglobin, V-CAM and PAI-1 compared to control group. Adiponectin levels tended to be lower in diabetic group, while resistin concentrations did not differ from control group. Rosiglitazone treatment improved diabetes compensation, significantly reduced VCAM-1, PAI-1 and E-selectin concentrations and increased adiponectin levels, while it did not affect serum resistin concentrations. Adiponectin concentrations at baseline were inversely related to E-selectin and MPO levels, this correlation disappeared after rosiglitazone treatment. We conclude that 5-month rosiglitazone treatment significantly reduced several markers of endothelial dysfunction. This effect could be at least in part attributable to marked increase of circulating adiponectin levels.
Relation of cholesterol metabolism and non-cholesterol sterols to insulin resistance
Authors: Šmahelová A , Hyšpler R , Haas T
Published: October 2021

Using non-cholesterol sterols investigation several authors postulated a hypothesis that in the metabolic syndrome cholesterol endogenous synthesis is increased and its absorption decreased. Our study is the first attempt to evaluate the direct relation of cholesterol metabolism to the principal pathogenetic phenomenon of the metabolic syndrome--namely to insulin resistance. We have measured insulin sensitivity by two methods--Quicki (Quantitative Sensitivity Check Index) and intravenous insulin tolerance test (Kitt) and 3 indirect markers--fasting insulin level, fasting C-peptide level and SHBG (sex hormone binding globulin). The investigation was performed in three groups of subjects with a different prevalence of insulin resistance: 72 non-diabetics with ischemic heart disease, 117 young blood donors and 63 type 2 diabetics on diet therapy only. Analyzing altogether 60 relationships--between four sterols (lathosterol, squalene, sitosterol and campesterol) and five markers of insulin resistance in three groups of subjects--we have found only six significant relations between cholesterol synthesis and absorption and insulin resistance in all groups of patients. Our results indicate that there exists a significant relationship between insulin sensitivity and indices of either increased cholesterol synthesis or decreased cholesterol absorption. Insulin resistance explains only a part of both abnormalities mentioned above.
Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats
Authors: Sivoňová M , Tatarková Z , Ďuračková Z , Dobrota D , Lehotský J , Matáková T , Kaplán P
Published: October 2021

Oxidative stress has been implicated to play a major role in aging and age-related diseases. In the present study, we investigated the effects of aging on the total antioxidant capacity, uric acid, lipid peroxidation, total sulfhydryl group content and damage to DNA in adult (6 months), old (15 months) and senescent (26 months) male Wistar rats. The antioxidant capacity, determined by phycoerythrin-based TRAP method (total peroxyl radical-trapping potential) was significantly decreased in the plasma and myocardium of old and senescent rats, whereas plasma level of uric acid was elevated in 26-month-old rats. Age-related decline in plasma and heart antioxidant capacity was accompanied by a significant loss in total sulfhydryl group content, increased lipid peroxidation and higher DNA damage in lymphocytes. Correlations between TRAP and oxidative damage to lipids, proteins and DNA suggest that the decline in antioxidant status may play an important role in age-related accumulation of cell damage caused by reactive oxygen species.
The effect of hyperthermia in vitro on vitality of rabbit preimplantation embryos
Authors: Makarevich AV , Olexiková L , Chrenek P , Kubovičová E , Fréharová K , Pivko J
Published: October 2021

The aim of our study was to test the influence of short exposure (6 h) of preimplantation rabbit embryos to elevated temperatures (41.5 degrees C or 42.5 degrees C) in vitro on their developmental capacity. Fertilized eggs recovered from female oviducts at the pronuclear stage (19 hpc) were cultured at standard temperature (37.5 degrees C) until the morula stage (72 hpc). Afterwards, the embryos were divided into two groups, cultured for 6 h either at hyperthermic (41.5 degrees C or 42.5 degrees C) or standard temperature (control 37.5 degrees C), post-incubated overnight (16-20 h) at 37.5 degrees C and then evaluated for developmental stages, apoptosis (TUNEL), proliferation (cell number), actin cytoskeleton and presence of heat-shock proteins Hsp70. It was observed that hyperthermia at 41.5 degrees C did not alter progression of embryos to higher preimplantation stages (expanded and hatching/hatched blastocysts), rate of apoptosis, total cell number of blastocysts and structure of actin filament compared to 37.5 degrees C. Western-blotting revealed the presence of heat stress-induced 72 kDa fraction of Hsp70 proteins in granulosa cells (exposed to 41 degrees C) and embryos (exposed to 41.5 degrees C). Following the elevation of temperature to 42.5 degrees C embryo development was dramatically compromised. The embryos were arrested at the morula or early blastocyst stage, showed an increased rate of apoptosis and decreased total cell number compared to control. The structure of actin filaments in most of blastomeres was damaged and such blastomeres often contained apoptotic nuclei. In this group a presence of heat-stress-induced fraction of Hsp70 proteins had not been confirmed. This is the first report demonstrating a threshold of thermotolerance of rabbit preimplantation embryos to hyperthermic exposure in vitro. A detrimental effect of higher temperature on the embryo is probably associated with the loss of their ability to produce Hsp70 de novo, which leads to cytoskeleton alterations and enhanced apoptosis.
Distinct patterns of histone methylation and acetylation in human interphase nuclei
Authors: Skalníková M , Bártová E , Ulman V , Matula P , Svoboda D , Harničarová A , Kozubek M , Kozubek S
Published: October 2021

To study 3D nuclear distributions of epigenetic histone modifications such as H3(K9) acetylation, H3(K4) dimethylation, H3(K9) dimethylation, and H3(K27) trimethylation, and of histone methyltransferase Suv39H1, we used advanced image analysis methods, combined with Nipkow disk confocal microscopy. Total fluorescence intensity and distributions of fluorescently labelled proteins were analyzed in formaldehyde-fixed interphase nuclei. Our data showed reduced fluorescent signals of H3(K9) acetylation and H3(K4) dimethylation (di-me) at the nuclear periphery, while di-meH3(K9) was also abundant in chromatin regions closely associated with the nuclear envelope. Little overlapping (intermingling) was observed for di-meH3(K4) and H3(K27) trimethylation (tri-me), and for di-meH3(K9) and Suv39H1. The histone modifications studied were absent in the nucleolar compartment with the exception of H3(K9) dimethylation that was closely associated with perinucleolar regions which are formed by centromeres of acrocentric chromosomes. Using immunocytochemistry, no di-meH3(K4) but only dense di-meH3(K9) was found for the human acrocentric chromosomes 14 and 22. The active X chromosome was observed to be partially acetylated, while the inactive X was more condensed, located in a very peripheral part of the interphase nuclei, and lacked H3(K9) acetylation. Our results confirmed specific interphase patterns of histone modifications within the interphase nuclei as well as within their chromosome territories.
Excessive oxygen uptake during exercise and recovery in heavy exercise
Authors: Yano T , Yunoki T , Matsuura R , Arimitsu T , Kimura T
Published: October 2021

The aim of this study was to determine whether excessive oxygen uptake (Vo2) occurs not only during exercise but also during recovery after heavy exercise. After previous exercise at zero watts for 4 min, the main exercise was performed for 10 min. Then recovery exercise at zero watts was performed for 10 min. The main exercises were moderate and heavy exercises at exercise intensities of 40 % and 70 % of peak Vo2, respectively. Vo2 kinetics above zero watts was obtained by subtracting Vo2 at zero watts of previous exercise (DeltaVo2). Delta Vo2 in moderate exercise was multiplied by the ratio of power output performed in moderate and heavy exercises so as to estimate the Delta Vo2 applicable to heavy exercise. The difference between Delta Vo2 in heavy exercise and Delta Vo2 estimated from the value of moderate exercise was obtained. The obtained Vo2 was defined as excessive Vo2. The time constant of excessive Vo2 during exercise (1.88+/-0.70 min) was significantly shorter than that during recovery (9.61+/-6.92 min). Thus, there was excessive Vo2 during recovery from heavy exercise, suggesting that O2/ATP ratio becomes high after a time delay in heavy exercise and the high ratio continues until recovery.
Advanced glycation end product pentosidine is not a relevant marker of disease activity in patients with rheumatoid arthritis
Authors: Šenolt L , Braun M , Vencovský J , Šedová L , Pavelka K
Published: October 2021

Advanced glycation end-product (AGE) pentosidine has previously been demonstrated in different tissues and body fluids. It was suggested as a novel marker for evaluating the pathologic activity in rheumatoid arthritis (RA). In this study we analyzed the relation between pentosidine and markers of inflammation, cartilage turnover, immune response, and disease status of RA. Using HPLC, we analyzed pentosidine in serum and synovial fluid from 39 patients with RA and in serum from 38 healthy controls. Cartilage oligomeric matrix protein (COMP) and antibodies to CCP (anti-CCP) were measured by ELISA. Clinical disease status was assessed by Disease Activity Score 28 (DAS 28) and functional status by Health Assessment Questionnaire (HAQ). We demonstrated significantly higher serum levels of pentosidine in RA patients in comparison with controls. Pentosidine in serum significantly correlated with pentosidine in synovial fluid. Serum pentosidine levels were associated with erythrocyte sedimentation rate (p<0.03) but not with CRP, COMP, anti-CCP antibodies, DAS 28, or HAQ. In contrast to previous studies, we could not show any correlation of pentosidine levels with inflammatory status, clinical disease activity, markers of immune response, or cartilage breakdown. However, AGEs can be suggested as important players participating in joint destruction rather than markers of disease activity.
Saccadic eye movement related potentials
Authors: Jagla F , Jergelová M , Riečanský I
Published: October 2021

The saccadic eye movement related potentials (SEMRPs) enable to study brain mechanisms of the sensorimotor integration. SEMRPs provide insight into various cognitive mechanisms related to planning, programming, generation and execution of the saccadic eye movements. SEMRPs can be used to investigate pathophysiological mechanisms of several disorders of the central nervous system. Here we shortly summarize basic findings concerning the significance of SEMRP components, their relationship to the functional brain asymmetry and visual attention level as well as changes related to certain neuropsychological disorders.
Militarised Authoritarian State and Informal Institutions: Zulm and Rasookh in Downtown Srinagar
Authors: Mir Touseef Y.
Published: October 2021

Kashmir is in a situation of protracted conflict. The paper offers an examination of daily life in the downtown of Srinagar, the region's capital.  The conceptual focus is on the role of informal institutions, here defined as ordered patterns of behavior, in this setting.  A particular concern with how these informal institutions explains how the different residents make sense of the generalized condition of what they term zulm.  Zulm refers to the experience of living with, enduring, and engaging with the administration of the militarized authoritarian Indian state, and can be disaggregated into a series of informal institutions deployed by citizens of downtown Srinagar.  Based on the ethnographic fieldwork, the paper looks at how differently situated individuals use these institutions – often in the form of networks, economic relationships, connections – to challenge and sustain relations with state structures.  The particular focus is given to the informal institution of rasookh. This thesis makes a contribution to the neo- institutionalist debate within conflict studies by drawing on the social side of the informal institutions. It also contributes to the regional studies literature on South Asia by documenting at close quarters the experience of protracted conflict in Kashmir.
Media and Climate Change in Pakistan: Perception of the Journalists in Mainstream Media
Authors: Manzoor Sajid , Ali Arshad
Published: October 2021

Climate change is a high matter of concern for every living being on this planet earth. This research paper explores the perception of Pakistani journalists related to media and climate coverage issues in Pakistan. The results of this paper are based on ten qualitative interviews of the journalists purposively selected from mainstream media in Pakistan covering climate issues. The journalists were of the opinion that lack of resources, old equipment, and poor human skill result in faulty measurements and information which leads to drawbacks in reporting authentic climate change. But fortunately, the actors associated with climate journalism are very well aware of their responsibilities and role.
Öğütülmüş Kolemanit Dolgulu Poliamid-6.6 Kompozit Malzemesinin Tribolojik Özelliklerine Dolgu Miktarının Etkisi
Authors: Şahin Şenol , Metin Furkan , Yılmaz Ayşegül Bodur
Published: October 2021

Bu deneysel çalışmada matris malzemesi olarak Poliamid-6.6 (PA) malzemesi ve dolgu malzemesi olarak da öğütülmüş kolemanit (KOL) kullanılarak oluşturulan PA/KOL kompozit malzemelerin tribolojik özelliklerinin KOL dolgu miktarına bağlı değişimi incelenmiştir. Bu kapsamda oluşturulması amaçlanan PA/KOL kompozit malzemeler için saf PA malzemesine ağırlıkça yüzde 12,5, 15, 17,5, 20 oranlarında KOL dolgusu yapılarak ilk olarak çift vidalı bir ekstrüder kullanılıp granül üretimi gerçekleştirilmiş daha sonra enjeksiyon kalıplama yöntemi ile çok amaçlı deney parçaları üretilmiştir. Saf ve kompozit malzemelere, TS ISO 4649 standardına göre yağlama olmaksızın sabit 5N yük, 40 d/dak tambur dönme hızı ve 40 m kayma mesafesinde aşınma testleri uygulanmıştır. Deneysel sonuçlar, saf PA malzemenin ve/veya PA/KOL kompozit malzemenin, tribolojik özelliklerinin, KOL dolgu miktarından etkilendiğini göstermiştir.
Enerji Santralinde Faaliyet Gösteren Buhar Kazanının NDT Tabanlı Periyodik Kontrolü
Authors: Kalkan İsmail , Şahin Murat , Tımaç Gökhan
Published: October 2021

Tahribatsız muayene teknikleri; işletme şartlarında stratejik veya teknolojik öneme sahip ve genelde endüstriyel uygulamalarda kullanılan malzemelerin üretim, kullanım veya işletme aşamasında ki süreçlerde oluşabilecek gözenek, korozyon, çatlak, aşınma, deformasyon, vb. kusur veya bozulmaların maddi kayıplara veya iş kazalarına sebep olmasını engellemek amacıyla bu kusurların bulunduğu malzeme veya bölgeleri, belirli standartlara ve disiplinlere bağlı kalmak şartıyla önceden tespit etmek amacıyla kullanılan tekniklerdir. Tahribatsız muayene yöntemiyle muayene edilen malzemeler kesinlikle deforme olmamakta ve muayene sonrasında da eskisi gibi kullanılmaya devam edilmektedir. Bu çalışmamızdaki amacımız; doğalgazdan elektrik üreten enerji santrallerinde yer alan buhar kazanlarının, TS EN 9712 standardı esas alınarak yetkilendirilmiş personellerce görsel muayene tabanlı olarak periyodik kontrollerinin yapılması ve elde edilen verilerin de ultrasonik ölçümlerle desteklenerek yorumlanabilmesidir. Bu sayede sektörde faaliyet gösteren veya göstermek isteyen tekniker veya mühendislerin NDT hizmeti, inspection hizmeti ya da önleyici ve kestirimci bakım çalışmalarına yönelik kaynak oluşturmak ayrıca yaptıkları çalışmaları raporlayabilmelerine yardımcı olabilmektir. Bu sayede literatürde yeterince yayın olmadığı için kaynak temini de sağlanması hedeflenmiştir.
Toplam Kalite Yönetiminde Ahilik ve Kaizen Felsefesi
Authors: Alparslan Cem , Aksoy İbrahim , Toktaş İhsan
Published: October 2021

Geçmişten günümüze yapılan üretimlerin tamamı her zaman müşteri ihtiyaç ve beklentisi doğrultusunda olmuştur. Müşterilerin bu ihtiyaç ve beklentilerinin üç temel unsur ile karşılanabildiği belirlenmiştir. Bu üç temel unsurun ise kalite, maliyet ve teslimat olduğu anlaşılmıştır. Sıralanan üç unsuru optimum seviyede dengelemeyi başaran şirketler, pazarda daima bir adım önde olmuşlardır. Bu bağlamda standartlaştırma ve sürekli iyileştirme metodolojileri kullanılarak tüm endüstrilerde çeşitli metotlar geliştirilmiş ve şartnameler oluşturulmuştur. Bu çalışma kapsamında standartlaştırma ve sürekli iyileştirme metodolojilerinin günümüz endüstrisinde kullanım alanları ve amaçları incelenmiştir. Ahilik sistemi başta olmak üzere geçmişten günümüze yapılan çalışmalar araştırılarak kullanılan yöntemlerin avantajları gözlemlenmiştir.
Prospects for intensifying the promotion of Ukrainian goods and services on foreign markets by trade diplomacy
Authors: Boyko Olena
Published: October 2021

The purpose of the article is to analyze the features and effectiveness of Ukraine’s trade diplomacy at the present stage, in particular in the field of promoting domestic goods for services to international markets.
The research methodology consists in the use of methods of analysis, synthesis, comparison, generalization, forecasting, as well as in the use of systemic, activity- based and historical approaches.
The scientific novelty is due to the fact that the article presents proposals for solving the problem of enhancing the promotion of Ukrainian goods and services to foreign markets by means of trade diplomacy.
Conclusions. As a result of the study, it was found that the further development of Ukraine’s trade diplomacy, basically, comes down to the pro-European direction and is closely related to the prospects for the implementation of «industrial visa- free» with the EU within the framework of the ACAA Agreement.
Key words: trade diplomacy, foreign trade policy of the state, efficiency, diplomatic relations, the art of negotiations, marketing research, strategies.
Regulation of nature management with the application of fiscal methods
Authors: Bodayuk Adam
Published: October 2021

The purpose of the article is to develop and apply the concepts and mechanism of fiscalization to the processes of managing the collection of payments from business entities to the budget for environmental offenses.
The research methodology - application of the resource approach to the defini- tion of concepts, abstract-logical, system-structural and comparative analysis, ranking.
The scientific novelty. The mechanism of fiscal management of nature users for their environmental pollution is revealed; the peculiarities of the calculation of the ecological tax, the distribution of the amounts of the current tax between the state and local budgets are indicated; applied innovations are substantiated taking into account the factor of ownership of natural resources.
Conclusions. The need for environmental fiscalization is due to the environmental situation in the country, the fiscal system, energy and industrial security, pricing policy, business activity, the country’s international obligations and other factors.
Key words: management, fiscal, in the use of nature, property, people, waste, pollution, rates, natural objects.
Peculiarities of formation of potential of telecommunications enterprises
Authors: Fedorenko Oleg
Published: October 2021

The purpose of the article – to analyze the peculiarities of forming the potential of a telecommunication enterprise and to suggest ways to increase the efficiency of its use. Research methodology. In the process of preparation of the article the methods of analytical, statistical and financial analysis were used. A scientific novelty is the proposal to use effective indicators of economic efficiency of the enterprise, such as profitability, profitability, cost, return on resources, investment, etc. to assess the effectiveness of the formation and use of the potential of the telecommunications enterprise. Conclusions. 1. The study of trends in the formation of the potential of telecommunications enterprises in Ukraine has determined that the pace of its development corresponds to the basic principles and principles of the concept of economic development and strategy of information society development adopted in Ukraine. The development of the economy of telecommunications enterprises is facilitated at the state level by developing new legislation in the information and telecommunications technologies sector in Ukraine, discussing and adopting new strategies for digital transformation aimed at using big data, blockchain, cloud technologies, robotics and the Internet of Things. 2. It is determined that the potential of a telecommunications enterprise is a unity of organizational, technical and information capabilities that contribute to the preparation and adoption of management decisions and influence its development. Features of capacity building determine the following components that ensure its functioning: software and hardware; personnel; information (databases); organizational, marketing, technical, technological, etc. 3. The system of financial indicators for definition of efficiency of functioning of the formed potential of the telecommunication enterprise is offered. 4. To ensure the formation of a strong potential of the telecommunications company in the work identified a number of key measures, including the creation of information systems, ensuring its operation by special staff, information security, creating new digital products and services, e-commerce and digital marketing. business analytics and big data management, etc.
Key words: telecommunication enterprises, capacity building, potential structure of telecommunication enterprise, evaluation indicators, state support.
The role and place of Ukraine in the innovative dimension of Europe
Authors: Bazyliuk Kseniia , Ladyk Sofii
Published: October 2021

The purpose of the article is to study the indicators of innovative development of Ukraine and determine its place in the innovation dimension among other European countries.
The methodological basis of the study is the use of general scientific methods: the method of theoretical generalization and comparison, as well as economic and statistical analysis, which are used to study indicators of innovative development of Ukraine and Europe, as well as modern computer technology for data visualization. The scientific novelty of the obtained results is that the main positive and negative tendencies, as well as perspective directions on the way of innovative development of Ukraine are revealed and its place in the innovation dimension
among other European countries is determined.
The paper analyzes the trends of innovation development of Ukraine for the period from 2012 to 2019. The study uses data from the Annual European Innovation Scoreboard (EIS) 2020, which publishes indicators of Ukraine and EU member states, as well as several non-European countries. It is established that in the vast majority of innovative areas Ukraine occupies the last positions among the considered countries. However, the analysis of the consolidated index of innovations shows that in recent years in Ukraine there is a tendency to slow growth of this index, and Ukraine belongs to the group of «modest innovators». For an in-depth analysis of the dynamics of innovation dimensions of Ukraine, the following types of indicators are also considered: «framework conditions»,
«investments», «innovation activities», «impacts».
Conclusions. It was found that in the vast majority of innovation areas Ukraine occupies the last positions, but in this area there are some positive changes. In particular, the international competitiveness of the scientific base has improved; the environment in which enterprises operate has become more favorable for innovation; there is an intensification of innovation in the business sector; the links between cooperation between innovation institutions have expanded. The conducted research can be used for the formation and implementation of innovative development strategies of Ukraine, which will increase its rating and international competitiveness.
Key words: innovation, innovative development, innovation index, dynamics, tendencies, competitiveness, innovative technologies.
Strategic analysis of the competitiveness of the enterprise
Authors: Grynchuk Yuliia , Muzychenko Andrii , Prykhod’ko Kseniia
Published: October 2021

The purpose of the article is to develop a methodology of strategic analysis of enterprise competitiveness.
The methodological basis of the research is the use of general scientific methods: the method of analysis and synthesis, theoretical generalization and comparison, and the means of modern computer technology for data visualization.
The scientific novelty of the received results consists of developing a logical and linguistic methodology of competitiveness analysis in the long term.
The article is devoted to the development of strategic analysis of the competitiveness of the enterprise.
Relevance of research is caused by enterprises management in the modern markets that use innovations of products or technologies, constantly face competition, and according to its condition, should make decisions on strategic development in conformity with the country’s development market inquiries the society. Thus, the problem is not only for new companies but also for those that already function in the market and carry out planning of economic activity to become the market leader, not to lose leadership, to keep the positions. The given methodology can be used by any enterprise irrespective of the type of activity, form of ownership, or strategic goals.
Conclusions. According to the study results, the methodology of strategic analysis, which is based on the study of potential internal development of the enterprise, taking into account the influence of external factors, which include macroeconomic factors of influence and market conditions. The basic approaches to the analysis of the competitiveness of the enterprise of foreign and domestic researchers are investigated in the article. The essential components of competitive advantages, which include price and non-price factors, are considered. Peculiarities of carrying out the analysis of the competitiveness of the enterprise after Porter are defined. The methodology of competitiveness analysis in the long term is developed. The main components of the strategic analysis are the estimation of activity scale in a long-term prospect, determination of strategic aims of the company, determination of aims of market coverage, selection of strategy type, selection of basic subjects of influence on competitive advantages, assessment of future relations with suppliers and buyers, assessment of cost price level, assessment of the quality of products and services and unique properties of products, formation of internal price policy.
Key words: strategy, strategic analysis, competitiveness, competitive advantages.
Analysis of the effectiveness of financing projects using crowdfunding
Authors: Horiacheva Kira , Tytomir Yuliia , Burdiuh Oleh
Published: October 2021

Purpose – analysis of key performance indicators (KPIs) for the success of innovative projects that try to raise funds indirectly through crowdfunding platforms. Research Methodology. The interdisciplinary method of discourse analysis and systematic approach were used in the context of this work; the comparative method allowed to determine the optimal approach to the problem. Scientific novelty. The field of financial support lacks tools to encourage market participants to provide them with ideas and projects that can be financed through crowdfunding. Conclusions. The following indicators influence the creation of a viable crowdfunding mechanism and the growth of fundraising: narrative (or previous history), a clear goal and planned duration of the project; investment in communication schemes and visualization of advertising, and third-party support (positive feedback) focus on the pledge process rather than on the financial goal; distribution of crowdfunding into structured categories. At the same time, the success of crowdfunding is not tied to the size of the reward and any location.
Key words: crowdfunding; key performing factors; alternative financin
Pericardial Abscess Associated with Mycoplasma arginini: A Rare Case from a Cat
Authors: ŞAHAN YAPICIER Özlem , AKAR Aybars , SİRİN Yusuf Sinan
Published: October 2021

A two and half-year-old, mixed breed, male cat was admitted to Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Animal Teaching Hospital with respiratory distress and coughing lasting for a month. During the initial examinations of ultrasound and radiography, a pericardial abscess was detected near the right side of the heart and was drained with pericardiocentesis. Percardial biopsy material was screened for the bacterial isolation and identification. Bacteriological methods based on colony morphology, sugar fermentation tests, and molecular confirmation using 16S rRNA-23S rRNA specific primers were performed. Result on conventional and molecular analysis, Mycoplasma arginini (M. arginini) were detected. The patient was treated with azithromycin and enrofloxacin. Full recovery was observed during follow-up examination after a month. The findings of this case increase awareness of pathogen M. arginini in cats and zoonotic importance has been emphasized for pet owners.