bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning for Wireless Network Throughput Prediction
Authors: Fernandez Gustavo A
Published: August 2023

This paper analyzes a dataset containing radio frequency (RF) measurements and Key Performance Indicators (KPIs) captured at 1876.6MHz with a bandwidth of 10MHz from an operational 4G LTE network in Nigeria. The dataset includes metrics such as RSRP (Reference Signal Received Power), which measures the power level of reference signals; RSRQ (Reference Signal Received Quality), an indicator of signal quality that provides insight into the number of users sharing the same resources; RSSI (Received Signal Strength Indicator), which gauges the total received power in a bandwidth; SINR (Signal to Interference plus Noise Ratio), a measure of signal quality considering both interference and noise; and other KPIs, all derived from three evolved node base stations (eNodeBs). After meticulous data cleaning, a subset of measurements from one serving eNB, spanning a 20-minute duration, was selected for deeper analysis. The PDCP DL Throughput, as a vital KPI metric, plays a paramount role in evaluating network quality and resource allocation strategies. Leveraging the high granularity of the data, the primary aim was to predict throughput. For this purpose, I compared the predictive capabilities of two machine learning models: Linear Regression and Random Forest. Metrics such as Mean Absolute Error (MAE), Root Mean Squared Error (RMSE) were used to examine the models as they offer a comprehensive insight into the models accuracies. The comparative analysis highlighted the superior performance of the Random Forest model in predicting the PDCP DL Throughput. The insights derived from this research can potentially guide network engineers and data scientists in optimizing network performance, ensuring a seamless user experience. Furthermore, as the telecommunication industry advances towards the integration of 5G and beyond, the methodologies explored in this paper will be invaluable in addressing the increasingly complex challenges of future wireless networks.
New approaches regarding the electrochemical behaviour of the Ti-6Al-4V alloy functionalized with antimicrobial peptide JI-2 via plasma polymerization
Authors: Teixeira Gabriella Teresinha Lima , Gelamo Rogério Valentim , Leite Natália Bueno , Moreto Jeferson Aparecido
Published: August 2023

Ti-6Al-4V alloy is widely used in the biomedical sector due to its excellent biocompatibility, corrosion resistance, and mechanical properties. However, the use of this material as an implant is still susceptible to failure due to bacterial adhesion on the surface. Initial studies performed by this research group demonstrated and characterized the functionalization process of the Ti-6Al-4V alloy with antimicrobial JI-2 peptide via plasma polymerization method. However, the electrochemical properties of the functionalized system are still little explored. Here, we present new insights regarding the global electrochemical behaviour of the functionalized Ti-6Al-4V with PAA/JI-2 in 0.6 mol L-1 NaCl solution. Open circuit potential and electrochemical impedance spectroscopy techniques were used. The electrochemical tests were accompanied by a detailed microstructural analysis by SEM. The results demonstrated the PECVD technique was advantageous to produce thin films based on acrylic acid monomer on the Ti-6Al-4V surfaces. The PAA/JI-2 thin films shifted the corrosion potential (Ecorr) of the Ti-6Al-4V alloy to more positive values, indicating a better thermodynamic stability. The capacitance of the barrier layer decreases for the uncoated specimens with increasing immersion time, suggesting an increase in the thickness of the native oxide layer. In contrast, the opposite effect was verified for the Ti-6Al-4V/PAA/JI-2.
Quantum chaos in 2D gravity
Authors: Altland Alexander , Post Boris , Sonner Julian , van der Heijden Jeremy , Verlinde Erik P.
Published: August 2023

We present a quantitative and fully non-perturbative description of the ergodic phase of quantum chaos in the setting of two-dimensional gravity. To this end we describe the doubly non-perturbative completion of semiclassical 2D gravity in terms of its associated universe field theory. The guiding principle of our analysis is a flavor-matrix theory (fMT) description of the ergodic phase of holographic gravity, which exhibits \mathrm{U}(n|n)U(n|n) causal symmetry breaking and restoration. JT gravity and its 2D-gravity cousins alone do not realize an action principle with causal symmetry, however we demonstrate that their universe field theory, the Kodaira-Spencer (KS) theory of gravity, does. After directly deriving the fMT from brane-antibrane correlators in KS theory, we show that causal symmetry breaking and restoration can be understood geometrically in terms of different (topological) D-brane vacua. We interpret our results in terms of an open-closed string duality between holomorphic Chern-Simons theory and its closed-string equivalent, the KS theory of gravity. Emphasis will be put on relating these geometric principles to the characteristic spectral correlations of the quantum ergodic phase.
La persistencia de la necropolítica: violencia contra los defensores indígenas ambientales en el Perú
Authors: De La Cruz Huamán Rosario Betzabeth
Published: August 2023

El presente artículo analiza la violencia ejercida contra los hombres y mujeres defensoras indígenas ambientales en el Perú. Cabe indicar que los defensores realizan un trabajo relevante en la protección de sus territorios y bosques, los cuales tienen un impacto favorable en sus comunidades y en la sociedad global, especialmente en el actual contexto de crisis climática. No obstante, si bien existen una serie de avances normativos internacionales y nacionales para proteger los derechos de los pueblos indígenas, existe también una brecha en su aplicación lo que, por un lado, deja entrever la persistencia de la violencia y, de otra parte, una necropolítica puesta en marcha: son vistos y tratados como enemigos “opositores al progreso” y, en consecuencia, son víctimas de actos de violencia que incluso, en algunos casos, ha llegado a la muerte. Frente a ello, en los últimos años, el Estado ha adoptado una serie de medidas específicas para proteger y prevenir esta situación; sin embargo, se advierten dificultades significativas en su implementación, lo que los coloca en una situación de vulnerabilidad y, simultáneamente, refuerzan, en el imaginario social, la naturalización de esta práctica necropolítica.
CONTRIBUIÇÕES POSSÍVEIS DA ECONOMIA SOLIDÁRIA DE PAUL SINGER À ECONOMIA DE FRANCISCO E CLARA
Authors: Guimarães Fernando Augusto de Souza , Guidotti João Victor Martins Toledo
Published: August 2023

Neste artigo são apresentadas as linhas mestras contidas na Economia de Francisco que buscam realmar o capitalismo. O chamamento de Mario Bergoglio em 2019 criou um movimento mundial que tem como principal objetivo lutar contra as desigualdades e pobrezas crescentes sem abrir mão da sustentabilidade e justiça social, em outras palavras, o objetivo é humanizar a economia. Neste sentido, tanto a obra quanto a trajetória de vida de Paul Singer podem ser utilizadas como parâmetros capazes de apontar possíveis direções desta mudança. Por isso, a partir da análise do pensamento de Paul Singer e de suas singularidades, se busca traçar as contribuições deste à Economia de Francisco.
Pyrazine Moiety: Recent Developments in Cancer Treatment
Authors: Sahu Rakesh , Shah Kamal , Gautam Yash , Sahu Kaushilya
Published: August 2023

Cancer is becoming more common worldwide, impacting the vast majority of people.
As a result, new anticancer drugs are currently being created, and their safety is still being
assessed. Pyrazine-based medications are a substantial contribution, as they are one of the
most important pharmacophores found in heterocyclic compounds both synthetically and naturally.
It's a six-membered aromatic heterocycle with two nitrogen atoms with a wide range of
therapeutic applications in drug development and numerous prospects for future enhancement
in anticancer drugs by targeting several critical receptors. A number of pyrazine compounds
have been shown to inhibit enzymes, receptors, and a range of additional cancer-fighting targets.
Researchers are currently focused on the creation of pyrazine-based novel derivatives for
cancer treatment in combination with other moieties. As a result, this review illuminates the
recent therapeutic expansion of pyrazine-based drugs, as well as their synthetic schemes, tabulated detailed clinical
trial drugs, marketed drugs with their primary target, and a list of recently patented and published research papers,
all of which will help scientists build successful medications with the appropriate pharmacological activity.
Pulmonary Aspergillosis in Naïve Non-neutropenic Lung Cancer Patients
Authors: Esmaeel Hend M. , Mohamed Sabah S. , Alhewaig Ayat A. , Aboul-Nasr Mohamed B.
Published: August 2023

Pulmonary aspergillosis is the most common mould infection of the lungs. Patients with chronic lung disease or mild immunodeficiency are at risk. Lung cancer represents an oncological challenge. Limited data are available about aspergillosis in newly diagnosed non-neutropenic lung cancer patients.

Objectives::

The aim of this work was to evaluate naïve lung cancer patients for the presence of as-pergillosis, identify fungal isolates, and determine antifungal susceptibility. The inhibitory effect of secondary metabolites of fungal isolates on the human fibroblast cell line was also assessed.

Results::

Aspergillus isolates were detected in 33 BAL samples out of the 69 patients (47.8%). The commonest isolate was A. niger. There was no significant correlation between total fungal count and age of patients. The antifungal Micafungin had a broad-spectrum and potent fungistatic activity against all fungal species, with A. niger being the most sensitive. MTT assay was performed to evaluate the cytotoxic effect of both A. niger and A. fumigatus on normal lung cells (WI-38) and re-vealed that toxicity was concentration-dependent and A. niger had significantly lower IC 50, indi-cating more toxicity.

Conclusion::

In the context of the diagnosis of lung cancer, maintaining vigilance is crucial to diag-nose fungal infection as aspergillosis. Initiation of proper management can help improve patient outcomes.
A Comparison of Self-esteem, Body Image, and Depression in
Hysterectomized and Non-hysterectomized Iranian Women: A Comparative
Cross-sectional Study
Authors: Ranjbar Minoo , Hasanpour Shirin , Mirghafourvand Mojgan , Rahmani Vahideh , Bani Soheila
Published: August 2023

Background:

Hysterectomy is one of the factors that may affect women's body image and
self-esteem and lead to serious psychological complications.

Objective:

The study aimed to compare self-esteem, body image, and depression in hysterectomized
and non-hysterectomized Iranian women

Methods:

In this cross-sectional comparative study, 140 women of the reproductive age, who have
undergone hysterectomy with benign causes, were compared in terms of self-esteem, body image, and
depression with 140 women receiving medical treatment due to abnormal bleeding in educational and
medical centers in Tabriz, Iran. Sampling was conducted by convenience method. Self-esteem was
assessed with the Rosenberg self-esteem questionnaire, body image was assessed with the multidimensional body-self relations questionnaire, and depression was assessed with the Beck II
depression inventory. Data were analyzed by Pearson correlation test, independent t-test, chi-square
test, and general linear model.

Results:

The mean (standard deviation) of the body image in hysterectomized and nonhysterectomized women was 235.3 (28.5) and 250.1 (23.4) out of an achievable score of 69-395, respectively. The mean (standard deviation) self-esteem score for hysterectomized women was 20.4
(4.8) and it was 24.2 (3.4) in non-hysterectomized women (out of an achievable score of 0-30). The
mean (standard deviation) depression score was 18.1 (9.7) and 5.5 (4.6) out of 0-63 in hysterectomized and non-hysterectomized women, respectively. The differences in self-esteem, body image, and
depression variables were statistically significant in hysterectomized and non-hysterectomized women, respectively (P<0.001)

Conclusion:

According to the results of the present study, the body image and self-esteem in
hysterectomized women were low compared to non-hysterectomized women, while the level of
depression was high, and this difference was statistically significant.
Molecular Dynamic, Hirshfeld Surface, Computational Quantum and
Spectroscopic analysis of 4-Hydroxy-1-Naphthaldehyde
Authors: Mir M. Amin , Jassal MMS , Andrews Kim
Published: August 2023

aims:

Computational Quantum and Spectroscopic analysis of 4-Hydroxy-1-Naphthaldehyde

Background:

Known also as 4-Hydroxynaphthalene-1-carbaldehyde, 4-hydroxy-1-naphthaldehyde (4H1NA) is a crucial precursor of many coordinating agents. A commercial compound called 4-hydroxy-1-naphthaldehyde (4H1NA) can be used to make a number of different sensors. In the development of many chemosensors, they operate effectively as a functionalized fluorescent backbone.

Objectives:

Molecular Dynamic, Hirshfeld Surface, Computational Quantum analysis of Naphthalde-hyde.

Methods:

The methods employed in the analysis of the compound involve the DFT calculations, using the DFT method and B3LYP/6-311++G (d, p) basis set with respect to its FTIR, NMR, and UV-Visible spectrum. The NMR chemical shifts of carbon and protons in CDCl3 were determined by the GIAO method. For the molecule of reference, HOMO-LUMO and Donor-Acceptor interactions were also taken into consideration. Investigations also looked into E.L.F., Fukui activity, and non-linear optical properties.

Results:

The investigation of compounds at their atomic level was analyzed using computational methods so that chemical, medicinal, and environmental research make use of them to make the molecule more in an improved form with distinguished properties. Strong interaction has been produced as a result of electron transfer from the oxygen atoms lone pair LP (2) to the anti-bonding orbital *(C3-C5) with a significant stabilization energy of 42.61kcal/mol. The attributes of the NLO molecule were calculated and found to be superior to those of the urea molecule, with linear and first-order hyperpolarizability situations. Our findings imply that the reference molecule can be a heavier contender for NLO as a surface material and could be considered a vital substance for medical purposes in the drug industry due to its maximum electrophilicity index.

Conclusion:

A commercial compound called 4-hydroxy-1-naphthaldehyde (4H1NA) can be used to make several different sensors. The compound has good structural and optical properties. They can be employed for a variety of optical limiting applications because of their unusual optical characteristic, which exhibits third-order non-linear behavior.
Ultrasound-Assisted Catalyst-free Synthesis of α,β -Unsaturated Amino
Acid Esters and Unsaturated Amino Ketones
Authors: Xie Guoshu , de Moura Ricketti Nicolas , Török Béla
Published: August 2023

Introduction:

Sonication has been introduced as a green and effective activation method for
the selective monoamination of β-dicarbonyl compounds. The simple one-pot process resulted in different
substituted β-amino-ɑ,β-unsaturated esters and ketones at room temperature with quantitative yields.
Aqueous NH4OH was used as a safe and economical nitrogen source for pressurized NH3 gas. The process
is considered green, accounting for not using any solvents and catalysts, besides some aqueous
NH4OH-involved reactions using nontoxic water. A broad variety of useful synthetic intermediates, β-
amino-ɑ,β-unsaturated esters and ketones have been prepared in short reaction time.

Methods:

Using this developed protocol, we were able to synthesize a series of structurally diverse β-
amino-ɑ,β-unsaturated esters and unsaturated amino ketones.

Results:

The synthesis of target compounds was achieved in a truly green process with high atom economy
and excellent yields in a catalyst-free one-pot system in an aqueous medium using simple, commercially
available, inexpensive ammonium hydroxide as the source of the nitrogen. The high atom economy
has been accompanied by the formation of a small amount of nontoxic waste, water.

Conclusion:

In conclusion, a simple, convenient, and high-yielding catalyst-free environmentally benign
method was developed for the synthesis of unsaturated amino acid esters and unsaturated amino ketones.
Impregnation of Fe3+ into MCM-41 Pores: Effect of Fe3+ Concentration on the Weight Percent of Fe-Frameworks and Fe-Non-Frameworks
Authors: Suyanta Suyanta , Kuncaka Agus , Mudasir Mudasir
Published: August 2023

Silica from rice husks (RH) has been used as a starting ingredient in the sonication synthesis of MCM-41 (RH-MCM-41). The impregnation of Fe3+ into RH-MCM-41 pores to produce RH-MCM-41 containing Fe2O3 and Fe (denoted as Fe2O3-Fe-RH-MCM-41) was carried out by examining the effect of various Fe3+ concentrations on the weight percent of Fe-frameworks (Fe3+ that replaces Si4+ in silicate frameworks) and Fe-non-frameworks, i.e., the iron oxide formed outside the silicate frameworks. Fe2O3-Fe-RH-MCM-41 was washed with a 0.01 M HCl solution to remove Fe-non-frameworks from the materials and give Fe-RH-MCM-41 containing Fe-frameworks. The Fe content in Fe2O3-Fe-RH-MCM-41 (Fe-total) and Fe-RH-MCM-41 (Fe-frameworks) for each sample was determined by an AAS (atomic absorption spectrometer), whereas the content of Fe-non-frameworks was calculated from the difference between Fe-total and Fe-frameworks. The XRD (X-ray diffraction) pattern, N2 adsorption-desorption isotherm profile, as well as the TEM (transmission electron microscope) image clearly demonstrate that the RH-MCM-41 exhibits an ordered p6mm hexagonal mesostructure with a large specific surface area and uniform pore size. Based on the weight percents of Fe-frameworks found in each sample, it is clear that the content of Fe-non-frameworks is significantly enhanced compared to that of Fe-frameworks when the more concentrated Fe3+ is used.
Synthesis, Characterization, and Magnetic Properties of Iron(II) Complex with 2,6-Bis(pyrazol-3-yl)pyridine Ligand and Tetracyanonickelate Anion
Authors: Fitriani Fitriani , Mulyani Irma , Onggo Djulia , Sugiyarto Kristian Handoyo , Bhattacharjee Ashis , Akutsu Hiroki , Santria Anas
Published: August 2023

The complex containing iron(II), 2,6-bis(pyrazol-3-yl)pyridine (3-bpp) as ligand, and tetracyanonickelate as counter anion has been synthesized and characterized. The characterization data suggest the corresponding formula of [Fe(3-bpp)2][Ni(CN)4]·4H2O. Meanwhile, the SEM–EDX analysis image confirms the existence of all elements contained in the complex except the hydrogen atom. The infrared spectra exhibit vibration bands of the functional groups of 3-bpp ligand and [Ni(CN)4]−1 anion. From magnetic property measurement, the complex's molar magnetic susceptibility (XMT) value is 2.65 emu mol−1 K at 300 K, which contains about 75% high-spin state of the Fe(II) complex. Upon lowering the temperature, the XMT value gradually decreases around 1.37 emu mol−1 K at 13 K. It decreases sharply to about 0.73 emu mol−1 K at 2 K. These values reveal that Fe(II) complex is in the low-spin (LS) state. As a result, the complex exhibited spin-crossover characteristics of gradual transition without thermal hysteresis, and the transition temperature occurred below room temperature with a transition temperature (T1/2) close to 140 K. The spin crossover property of the complex is supported by a thermochromic reversible color change from red-brown at room temperature to dark brown on cooling in liquid nitrogen associated with the high-spin to low-spin transition.
CLINICO-TRICHOSCOPIC EVALUATION OF HIRSUTISM TREATED WITH INTENSE PULSED LIGHT IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA
Authors: CHINJITHA DAVIS T , Joyeeta CHOWDHURY , Suchibrata Das , Arun Achar , Alok Roy K
Published: August 2023

Objective: The objective of this study is to determine the effectiveness of Intense Pulsed Light in treating hirsutism after three sittings, as evaluated through clinical and trichoscopic assessments, in patients attending a tertiary care hospital in Eastern India.
Methods: This was a Descriptive Longitudinal study conducted at the Dermatology Outpatient Department (OPD), Government Medical College, Kolkata, from March 2019 to February 2020. The study included 40 cases of Dermatology OPD attendees who complained of hirsutism. Trichoscopy was used to evaluate treatment response. Data were analyzed using Medcalc.
Results: Seventy percent had functional while 30% had organic hirsutism; 65% patients had PCOD and 27.5% had idiopathic hirsutism. All the patients had significant improvement with intense pulsed light with regard to terminal-vellus hair ratio and Terminal hair density observed with trichoscopy irrespective of their medical treatment. The mean modified visual analog score was 6.75±1.1209. According to the modified visual analog score, 57.5% had good reduction while the rest had a moderate reduction.
Conclusions: The majority had functional hirsutism. Polycystic ovarian disease and idiopathic hirsutism are the most common causes of hirsutism. Intense pulsed light is an effective and safe method of hair removal, regardless of medical treatment, and trichoscopy can be used to evaluate treatment response.
ASSESSING KNOWLEDGE OF HAND HYGIENE AMONG CBME AND NON-CBME MEDICAL UNDERGRADUATES: A QUESTIONNAIRE-BASED SURVEY
Authors: Balaraman Ramani , Manavalan Jayavarthinni , Banaji Nandita
Published: August 2023

Objective: The objective of the study is to evaluate the knowledge of hand hygiene among CBME and non-CBME medical undergraduates.
Methods: A descriptive cross-sectional questionnaire-based study was carried out among 390 medical undergraduate students of CBME (1st, 2nd, and 3rd year) and non-CBME batches (4th year and interns). The data collection tool containing 25 close-ended questions from WHO’s “Hand Hygiene Knowledge Questionnaire for Health-Care Workers” was circulated to the participants as Google forms. Each correct response was given a score of “1” and each wrong response was given a score of “0”. Based on the total score obtained, the knowledge level of hand hygiene of each participant was categorized into good, moderate, or poor. Data were analyzed using OpenEpi software.
Results: A total of 390 medical students including interns participated in this study, of which 222 (57%) were from the CBME batch and 168 (43%) were from the non-CBME batch. Of the 25 questions, >75% of the participants responded correctly to 13 questions. Statistical significance (p<0.05) was observed with 5 questions in which the non-CBME students had better knowledge than CBME students. However, most of the participants (n=288) had a moderate level (73.85%) of knowledge of hand hygiene.
Conclusion: The knowledge gap about hand hygiene could lead to avoidance of regular usage of hand rub and poor compliance with it. Hence, it is important to address it during training sessions to ensure better hand hygiene practices.
DETECTION OF EXTENDED SPECTRUM BETA LACTAMASES-PRODUCING KLEBSIELLA PNEUMONIAE ISOLATES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASES PATIENTS
Authors: R Shangamithra , R Saraswathi , A Anupriya , P Chitra Rajalakshmi , J Lalithambigai
Published: August 2023

Objective: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide which includes chronic bronchitis and emphysema. 80% of acute exacerbation of COPD (AECOPD) are triggered by respiratory viruses, atypical bacteria, and aerobic Gram-positive and Gram-negative bacteria. The aim of our study was to analyze the prevalence and antimicrobial susceptibility testing of Klebsiella pneumoniae and detection of extended spectrum beta lactamases (ESBL)-producing K. pneumoniae isolates from COPD patients.
Methods: Sputum samples received from seventy-five diagnosed cases of COPD from the department of General Medicine and Chest Medicine, TSRM MCH and RC, Trichy, from March 2022 to August 2022. Direct Gram stain was done for all sputum samples. The suitable sputum samples were cultured. The identification of organism and antimicrobial susceptibility testing was done by standard microbiological techniques.
Results: Out of seventy-five cases, 64% were males and 36% were females. Forty-seven were sputum positive, and the prevalence of Gram- negative bacteria was 64%. K. pneumoniae was the most common bacteria isolated (42.2%), followed by Pseudomonas aeruginosa (15.5%). Antimicrobial susceptibility testing of K. pneumoniae was sensitive to imipenem (78.94%), aminoglycosides (78.94%), amoxycillin-clavulinic acid (63.15%), ciprofloxacin (57.89%), Piperacillin-Taxobactam (57.89%), and the phenotypic tests showed 13 (68%) isolates were ESBL producers.
Conclusion: This study showed that K. pneumoniae and P. aeruginosa are the most common organisms associated with AECOPD and increased rate of ESBL producers were observed.
ROLE OF MRI IN EVALUATION OF SEIZURE DISORDER
Authors: SINGLA NEERAJ , Singh Jarnail , Kaur Amarjit , K Badhan Rajesh
Published: August 2023

Objectives: The present study was conducted to identify structural abnormalities on the brain imaging that may be associated with the cause of seizures and to study the spectrum of MRI findings in patients with seizures.
Methods: This time-bound descriptive study was conducted on 100 seizure patients in the department of radiodiagnosis of GMC, Patiala. Informed consent was obtained and then MR imaging of brain was done. The results were analyzed.
Results: Mean age was 39.59±15.96 years (range: 18–85 years) with 70% male and 30% female patients. The majority of the patients (80%) had generalized tonic–clonic seizures, followed by myoclonic seizures (8%), simple partial seizures (5%), complex partial seizures (2%), absence seizures (2%), motor seizures (1%), febrile seizures (1%), and tonic seizures (1%). The mean seizure duration was 2.15±1.48 months. On magnetic resource imaging (MRI), 44% patients had normal MRI. In remaining patients, MRI findings were infarct with gliosis (20%), ring enhancing lesions (18%), atrophy (6%), neoplasm (4%), thrombosis (3%), venous malformation (2%), and developmental malformations (3%).
Conclusion: The most common type of seizures is GTCS. MRI can be normal in the majority of the patients of seizures. Common MRI abnormalities were infarct with gliosis and ring-enhancing lesions. Hence, MRI plays a significant role in the initial evaluation of seizures patients to rule out any organic or developmental lesions.
COMPARATIVE EVALUATION OF THE EFFECTS OF DEXMEDETOMIDINE-PROPOFOL AND FENTANYL-PROPOFOL ON VARIOUS PARAMETERS DURING I-GEL INSERTION
Authors: KC Suja , R Sethunath , Joseph Elizabeth , Cheeran Susan T
Published: August 2023

Objectives: Supraglottic airway devices (SGAD) have become inevitable for routine and difficult airway management and various induction agents are used for SGAD insertion. The present study compares the insertion conditions for I-gel, using Dexmedetomidine and Fentanyl with Propofol.
Methods: Sixty patients were included in the study and randomly divided into two groups. Group D received 1 mcg/kg Dexmedetomidine and Group F received 1 mcg/kg Fentanyl. The mean arterial blood pressure (MAP) and heart rate (HR) were recorded at baseline and after 1’, 3’ 5’, and 10’ after insertion.
Results: A significant decrease in HR was seen in Group D at 3’, 5’, and 10’ after insertion when compared to its respective time intervals in Group F. However, when MAP was observed, the 5’ after insertion showed a decrease in blood pressure within the groups but when MAP between groups were compared, there was no significant variation between Group F and Group D at their respective time intervals after insertion. HR was significantly reduced with Dexmedetomidine compared to that with Fentanyl.
Conclusion: Co-induction of Propofol with Fentanyl or Dexmedetomidine 1 mcg/kg provides satisfactory hemodynamic stability and comparable insertion condition for I-Gel.
DIAGNOSIS AND TREATMENT OF MUCORMYCOSIS: AN INTRUDER POST-COVID-19
Authors: Kesharwani Disha , Mishra Sandhya , Verma Bhumika , Verma Kamini , Suraj Banjare
Published: August 2023

Mucormycosis can be elaborated as mycosis due to Mucorales. Mucormycosis is an angioinvasive infection. Fungi of Mucorales order is the causative organism of mucormycosis and pertains to the class of zygomycetes. It is ordered on number third after candidiasis and aspergillosis in the category of invasive mycosis. Rhizopus arrhizus (oryzae) is the most important species which cause this disease. It is categorized as a disease with high mortality. There is a 46% chance of mucormycosis with person having sinus infection, 76% of chances with pulmonary infection, and 96% for disseminated Mucormycosis. The COVID-19 pandemic precipitated this disease in a common way. Around 90% of the population was exposed to coronavirus disease 2019 (COVID-19) infection during the pandemic which ultimately affected the immunity of individual, leading to increased chance of exposure to other infectious disease. Mucormycosis is one of such disease which can highly affect the individual with COVID-19 infection in patient’s history. This review presents a brief about the disease origin, occurrences, types, signs and symptoms, risk factors, diagnosis, and treatments available, along with recent patents. This review also elaborated the treatment of COVID-19-associated mucormycosis and other risk factors. It was found that the diagnosis is not simple and easy sometimes it was observed postmortem also. This review also focuses on various methods with which easy diagnosis of this dreadful disease can be done.
ANIMAL MODELS OF DIABETIC NEPHROPATHY
Authors: Azizah Dira Ummul , Bahtiar Anton , ANGELINA MARISSA
Published: August 2023

Diabetic nephropathy (DN) is the most common complication of diabetes mellitus (DM). It is characterized by high blood glucose levels or hyperglycemia and is accompanied by changes in lipid, carbohydrate, and protein metabolism which can lead to an increased risk of complications due to vascular disease. DN is probably the most insidious among these complications, causing substantial morbidity and mortality. In this article, we will review the literature on animal models of diabetes. We will discuss several species as animal models for Type 1 and 2 diabetes, including zebrafish, rabbits, mice, rats, and rat models. This article also provides various methods used in research with model animals and presents the required result for studying diabetic DN.
FETOMATERNAL OUTCOME IN PATIENTS WITH THREATENED ABORTION IN A TERTIARY CARE CENTER IN SOUTH KERALA
Authors: Mammen Kitty Elizabeth , VENUGOPAL PRASANNA , S ASIYA
Published: August 2023

Objective: Pregnancy complications due to threatened abortion are related with contrary pregnancy outcomes. The main aim of the present study was to analyze the changes in pregnancy outcomes among the women who experienced threatened abortion and normal pregnant control women.
Methods: This retrospective observational study was performed among 117 pregnant women who were attending our Travancore Medical College Hospital, Kollam, during the period from January 2021 to January 2023 (2 years). The control group was developed from an equal number of asymptomatic women who were receiving antenatal care during the same period. Demographic parameters, clinical and ultrasound observations, treatment plans, and pregnancy outcomes were analyzed.
Statistical Analyses: Data were analyzed using IBM SPSS Statistics.
Results: Spontaneous abortion rate of 15.38% was observed with the threatened abortion group and control group as 5.1% (p=0.005). Women with threatened abortion had higher odds for placenta previa (p=0.048), pre-mature rupture of membranes (p=0.021), post-partum hemorrhage (p=0.001), and pre-term birth.
Conclusion: Threatened abortion seems to be an important hazard to fetal survival and may intensify the threat for operational delivery.
COMPARATIVE STUDY OF THE EFFICACY OF INTRAVENOUS PARACETAMOL AND DEXMEDETOMIDINE ON POST-OPERATIVE ANALGESIC AND HEMODYNAMICS FOR PATIENTS UNDERGONE UPPER LIMB SURGERY
Authors: Parween Jainab , KHAN FAHAD
Published: August 2023

Background: Comparative study of the efficacy of intravenous paracetamol and dexmedetomidine (DMED) on post-operative analgesic and hemodynamics for patients undergone upper limb surgery. Multimodal analgesia is recommended to reduce the stress response and prevent post-operative pain. Intravenous paracetamol and intravenous DMED are both effective components in respect of multimodal analgesia.
Methods: The present prospective randomized, double-blind, controlled study was performed on eighty American Society of Anesthesiologists (ASA) Grade I and Grade II physical status patients aged 18–65 years, of both genders, were selected for elective upper limb orthopedic surgical procedure under general anesthesia. Group P (paracetamol) patients were given 1 g paracetamol intravenously 30 min before surgery. Group D patients, 100 μg DMED/20 mL normal saline, was administered intravenously 30 min before surgery. Post-operative hemodynamic variables, post-operative pain scores (Visual Analogue Scale score), need for rescue analgesics and post-operative complication were recorded and treated accordingly.
Results: In both groups, females were in the majority with ASA grade I in the majority of the cases in both groups. Mean heart rate, mean arterial pressure, and Visual Analog Score for pain were comparable between the groups were compared at different time intervals (2, 4, 6, 12, 18, and 24 h) (p>0.05). Regarding complications Nausea, vomiting, itching and stomach irritation was in 17.5%, 15.0%, 7.5% and 20.0% for group D and for group P nausea and vomiting was in 15.0% and 10.0% and no other complication occurs in group D.
Conclusion: Pre-emptive administration of paracetamol is a cost-effective and safe method of providing post-operative analgesia for patients undergoing upper limbs surgery.
DEXMEDETOMIDINE 1 µg/kg VERSUS MAGNISIUM SULPHATE 30mg/kg IN ATTENUATING STRESS RESPONSE DURING DIRECT LARYNGOSCOPY AND INTUBATION – A COMPARATIVE STUDY
Authors: SEKHAR UPPUTURI VIJAYA , SARASWATH I CHIRANJEEVI , PRADEEP M VENKATESWARA , T Phaneendra Reddy
Published: August 2023

Background: In patients who undergo general anesthesia, the need for intubation and laryngoscopy is paramount. There will be hemodynamic changes in the body which occur due to intubation ultimately leading to stress.
Aim: The aim of the study was to compare the efficacy of dexmedetomidine 1 μg/kg and magnesium sulfate 30 mg/kg in reducing the stress response occurring due to intubation and laryngoscopy.
Methods: A randomized and double-blinded study was carried out in 60 participants who were divided into two groups. Group D were given dexmedetomidine 1 μg/kg while Group M were given magnesium sulfate 30 mg/kg. The baseline vitals were monitored at 0, 1, 3, 5, and 10 minutes after intubation.
Results: The heart rate and blood pressure showed an increase in both the groups after intubation. However, the pre-induction values were reached earlier in the Group D when compared to the Group M patients.
Conclusion: The patients who were pre-induced with dexmedetomidine 1 μg/kg showed a better hemodynamic stability when compared to those given magnesium sulfate 30 mg/kg.
A COMPARATIVE STUDY OF INFLAMMATORY MARKERS LEVELS IN PATIENTS OF TUBERCULOSIS AND COVID-TB COINFECTION
Authors: APARAJITA KUSHWAHA  , SOHIL TAKODARA  , NEHA SHARMA  , BADRI LAL JAT  , RAJU RAM
Published: August 2023

Objective: The outbreak of COVID-19 has increased the vulnerability of global population to diseases; above all, the patients suffering from tuberculosis (TB) COVID-19. Both being diseases of the respiratory tract, a confection of the two might cause severe implications. The WHO has set a goal of eradicating TB globally by the year 2035 (END-TB program). To achieve this goal, various initiatives are being taken with respect to early diagnosis, screening – research and development of new diagnostic as well as treatment tools. Although, the pandemic largely interrupted these initiatives setting back progress by approximately a decade; it should not be overlooked that COVID-19 has unlocked new doors to research and development in the niche of infectious diseases. This study was aimed at analyzing of inflammatory markers in patients of TB, COVID-19, and COVID-TB confection.
Methods: A total of 164 patients aged between 18 years to 85 years were included in this study. Total patients (164) were, then, divided into three groups on the basis of their disease diagnosis. The patient groups are as follows: 57 COVID-19-positive patients, 53 COVID-TB coinfection-positive patients, and 54 TB-positive patients. Serological analysis data of C-reactive protein (CRP), D-dimer, and SGOT were statistically analyzed using one-way ANOVA.
Results: The results of analysis of variance showed significant results for all three inflammatory markers with p<0.05. The levels of CRP, D-dimer, and SGOT underwent the highest increase among COVID-TB coinfection patient.
Conclusion: Through this study, it can be concluded that the addition of inflammatory markers testing in TB patients and diagnostic protocols may prove to be of significant assistance in diagnosis of TB and also to estimate the severity of infection in patients of active TB. It is also noteworthy that the levels of these markers were found to be highest in patients suffering from a coinfection of both the diseases.
Researcher Reliance on Digital Libraries: A Descriptive Analysis
Authors: Yadav Sushil Kumar
Published: August 2023

The digital library is an information technology that is structured as a digital knowledge resource, or can be alluded to a medium that stores information for a huge scope and is teamed up with the information the board gadget equipped for showing the information or information required by the client. Digital libraries can be extensively characterized as an information stockpiling and recovery frameworks that control digital information in the media (text, pictures, sound, static or dynamic) on the web. The main aim of this study is to study the awareness and using pattern of digital library by the researchers, to analyse the influence of digital library on researchers’ efficiency, analyse the purpose of using Digital Library Consortium, decide the effect of problems and motivational components of the digital library on the users, evaluate the satisfaction level of users with coverage of journals and perspectives on training and awareness programs and propose the available resources for effective utilization of the Digital Library.
The Role of Digital Libraries as Information Resources for Scholars: A Descriptive Analysis
Authors: Yadav Sushil Kumar
Published: August 2023

Information is actually viewed as the fulcrum for prosperity and strength and extremely important for social and economic development of the society. The revolution in Information and Communication Technology has bridged knowledge gap by offering free flow of information. The PG Students generally gather information from internet and furthermore from the reference books, since they need to plan cases, Projects, assignments and so on. Undoubtedly, they generally utilized the books, reference books, contextual analyses, to gather information and sometimes they gathered information from online database. Due to Around the world Web, access to the web is now a part of the everyday living of ours. An enormous number of user’s rummage around the snare each day. More and more folks have to seek out indexed collection.
Re-Inventing Tradition and Decolonizing the Stage: A Study of Girish Karnads Plays
Authors: Manju Manju , Singh Dr. Nempal
Published: August 2023

This postmodern blurring of cultural lines has resulted in a universal humanity that can be accessed via a single body of knowledge. The epiphanic moment of confronting the other shifted the focus from Europe to the East, where scholars realized that the epistemic discourse of their own countries reflected the same a priori delimitation of knowledge. The Radhakrishnan Commission, for example, proposed in 1948 that the fields of natural science, social science, and the humanities should study different aspects of reality: facts, events, and values, respectively. In order to dismantle the epistemic dominance of western knowledge and eradicate the homogeneity of discourses, the time has come to highlight, as Bakhtin would have it, the importance of comparative dialogic in establishing cross-cultural dialogic. In a same vein, the Orientalist paradigm has to shift toward a focus on humanistic conversation between South and South and a reconfiguration of the Asian dilemma of singularities. To get a holistic comprehension of human beings, a paradigm shift and rethinking—what Derrida terms Transformed Humanities, New Humanities—is essential.
Geographical Analysis of the Challenges and Opportunities Facing Jharkhand's Irrigation Sector
Authors: Shukla Rajkaran , Singh Surajbhan
Published: August 2023

India is a land of rivers having prevalently a farming-based economy. Agriculture is the fundamental supporter of most of the general population in India and water is the most significant contribution to crop generation. The accomplishment of agriculture relies on the sufficiency and timely event of precipitation. Yet, the precipitation in India is frequently meagre, uneven and there is indeed, even all out disappointment in certain districts and during certain periods. Downpour is bound to a couple of months in a year and it shifts from year to year and district to-area which makes enormous pieces of the nation defenceless against drought. In this manner, natural distribution of water is lacking both spatially and transiently. Aside from the distinction in money saving advantage of good irrigation in various mouzas and diverse irrigation systems, the spatial example is likewise uneven at small scale level for example one irrigation framework to another irrigation framework. The Z-Score an incentive if there should be an occurrence of Co-employable RLI (+1.80) scored most astounding which shows the greatest net benefit for boro development. The most minimal score which is seen in the STW (leased) (- 1.42) poor inundated zone shows minimal benefit for boor development.
GIS-based Road Network Analysis and Bus Route Evaluation in Futian District, Shenzhen
Authors: Tan Jiapei , Wang Ruei-Yuan , Zhu Zhe , Wang Zishen , Hou Sixian , Zhang Ying , Jie Yuyu , Yuan Xinxin , Hou Xiaoqi , Liao Yinghua
Published: August 2023

Futian District is the central urban area of Shenzhen and one of the busiest and most dynamic urban areas. This article is based on the spatial analysis method (slop, density, road area); Simultaneously, using research methods such as average station distance, nonlinear coefficient, service area, and public transportation network repetitive coefficient, combined with national standards, this study analyzes and evaluates the urban road network and public transportation network in Futian District, Shenzhen. The results show that: firstly, the overall difference in road network density in Futian District is significant, with a characteristic of high density in the southeast and low density in the northwest. The transportation network is mainly distributed in the east, south, and west regions. Secondly, the shortcomings of the planning in this area were manifested in the non-compliance of the urban road area with national standards, the high nonlinear coefficient of bus routes, increased time and travel costs for residents' bus travel, and a bus service area within 500 m far below national standards. Reflecting on the sustainable development of urbanization in the area, we should address the shortcomings in road design and public transportation layout, explore our own advantages, and adjust planning strategies to seek new directions and strategies.
La paz sin engaños. Estrategias de solución para el conflicto colombiano
Authors:   Universidad de La Salle, Ramírez-Orozco Mario
Published: August 2023

La paz es una necesidad imperiosa para Colombia, un país donde se mantiene latente por más de medio siglo un grave conflicto político, social y armado. Pero no se trata de una paz cualquiera, sino de una paz de carácter estructural que supere las secuelas producidas tanto por la violencia directa, como por los efectos inherentes a otras formas de violencia indirectas o encubiertas. De manera que la ausencia de guerra o conflicto armado sea concomitante a la superación de las desigualdades extremas, la integración de las poblaciones excluidas y el goce efectivo de los derechos ciudadanos para toda la población.
Ética e interculturalidad en América Latina
Authors:   Centro de Investigaciones sobre América Latina y el Caribe, Reding Blase Sofía
Published: August 2023

Las ciencias sociales y la ética tienen por delante el desafío que trae consigo la diversidad cultural, en especial cuando ésta se presenta en contextos culturales marcados por una historia de explotación y humillación. En este libro se muestra que los procesos de colonialismo y racismo estatal siguen siendo un obstáculo para el diálogo entre culturas, y que incluso el llamado multiculturalismo responde a intereses propios del racionalismo occidental, cuando no a las expectativas de un mercado cultural hambriento de novedades.
Colectivos poéticos emergentes en Nicaragua 1990-2006
Authors:   ENES Morelia UNAM, Chavolla Mc Ewen José Jaime
Published: August 2023

La historia de Nicaragua díficilmente podría entenderse sin considerar la profunda influencia de los escritores y en especial, de los poetas. Esta nación centroamericana, de hecho, ha sido llamada como la "República poética" por la importancia que tienen éstos en el desarrollo nacional. No obstante, el privilegio de ser reconocidos como tles está resguardado por las cúpulas consagradas y obstaculizado por una heterogeneidad de condiciones históricas que permean a este país.
Fuera de las revistas científicas
Authors: Licea de Arenas Judith , Carmona Victoria Verónica
Published: August 2023

La falta de integridad de investigadores y de instituciones es un tema delicado. Por ello, es necesario que los científicos estén conscientes de su papel en la sociedad para actuar éticamente. Los medios de comunicación e Internet, por su parte, deben ofrecer información veraz para contribuir a la educación de la población a través de la divulgación científica.
Competencias informacionales: Un reto para el aprendizaje y la enseñanza en el siglo XXI
Authors: Sánchez Ambriz Gerardo , Pérez Balbuena José de Jesús
Published: August 2023

El documento tiene como objetivo: enunciar las competencias informacionales como el eslabón pertinente para lograr una interfaz entre las necesidades educativas en las instituciones de educación superior (IES) y la labor docente, en el sentido de mitigar la obsolescencia del conocimiento para acceder a lo mejor de la literatura científica concentrada en bases de datos bibliográficas, así como para la creación de nuevo conocimiento mediante procedimientos específicos del quehacer cotidiano de educandos de pregrado y posgrado. El tipo de investigación es documental, con un alcance descriptivo.