bluuebunny/crossref_metadata_2025 huggingface dataset:
Shared-Use Decisions Among Administrators of Physical Activity Facilities in Pasadena, TX
Authors: Stasi Selina Marie , Spengler John Otto , Maddock Jay , McKyer Lisako , Clark Heather
Published: April 2019

Background and Purpose. The American Heart Association recommends community-based research on shared use of physical activity (PA) spaces. Pasadena, a community in southeast Houston, Texas with lower socioeconomic status and racial/ethnic diversity, was the setting for our study. Efforts to increase access to PA in Pasadena include building the evidence on PA resources. The purpose of this research was to utilize survey data in a community setting to inform and target efforts around sharing PA spaces. Method. An online survey was administered to K-12 school ( n = 25) and park ( n = 30) administrators, church leaders ( n = 10), community organizations ( n = 2), a health care center, and a local business. Results. Park facilities in Pasadena shared by agreement with two high schools and three baseball/softball leagues were ballfields, tennis courts, and jogging paths. No park facilities were shared with faith-based organizations. Four parks communicated daily, and five schools communicated with parks quarterly about providing opportunities for PA. Key facilitators to sharing facilities were building relationships and collaboration, service to the community, and improving health. Key barriers were cost, maintenance, staffing, and prioritizing use with limited time, facilities, and resources. Conclusions. This study is the first of its kind to address shared use at the community level and suggests opportunities to improve communication and partnerships between parks, schools, and churches. This research will inform ongoing efforts to promote access by identifying barriers and motivators among stakeholder groups to help facilitate shared use agreements.
Effect analysis of emotions on driving intention in two-lane environment
Authors: Wang Xiao-yuan , Liu Ya-qi , Han Jun-yan , Liu Shi-jie , Xia Yuan-yuan , Zhao Hai-xia
Published: April 2019

Driving emotion plays an important role in intention generation and behavior decision. It is an important premise to understand the influencing mechanism of driving emotion on intention correctly for the realization of driving intention identification, active vehicle security warning, and intelligent driving. In the case of two-lane, multi-source dynamic data of human–vehicle–environment under drivers’ different emotional states is obtained through actual and virtual driving experiment in this article. Considering the influence of emotion on intention, the probability distributions of the driving intention in different emotions are obtained by means of the immune algorithm. And the priming effect of vehicle driving emotion on intention was analyzed deeply. The research results can provide theoretical foundation for the research of driving intention identification, active vehicle security warning system, and intelligent driving command system under the condition of Internet of things.
Palliative care for people with non-malignant respiratory disease and their carers: a review of the current evidence
Authors: Mc Veigh Clare , Reid Joanne , Larkin Philip , Porter Sam , Hudson Peter
Published: April 2019

Background

Internationally, non-malignant respiratory disease is on the increase. However, although palliative care is recommended as an appropriate healthcare option for this client group, evidence suggests that these patients and their carers do not receive the same standards of palliative care as patients with a malignant lung condition.

Aim

The aim of this review was to provide a critical overview of the current evidence base in relation to the palliative service provision for people with non-malignant respiratory disease and their carers.

Methods

A review of the literature was conducted in July 2015 and updated in October 2017 and focused on the palliative care service provision for patients with interstitial lung disease, chronic obstructive pulmonary disease and bronchiectasis.

Results

In total, 71 empirical studies were included in the review and grouped into two main themes: patient and carer’s bio-psychosocial symptom needs and management, and palliative care service provision for patients with non-malignant respiratory disease and their carers.

Conclusion

The majority of palliative research focuses on patients with a diagnosis of chronic obstructive pulmonary disease. A deeper insight is required into the palliative service provision experienced by those with other forms of non-malignant respiratory disease such as bronchiectasis and interstitial lung disease.
Re-reconsidering the role of temporal order in spoken word recognition
Authors: Gregg Julie , Inhoff Albrecht W , Connine Cynthia M
Published: April 2019

Spoken word recognition models incorporate the temporal unfolding of word information by assuming that positional match constrains lexical activation. Recent findings challenge the linearity constraint. In the visual world paradigm, Toscano, Anderson, and McMurray observed that listeners preferentially viewed a picture of a target word’s anadrome competitor (e.g., competitor bus for target sub) compared with phonologically unrelated distractors (e.g., well) or competitors sharing an overlapping vowel (e.g., sun). Toscano et al. concluded that spoken word recognition relies on coarse grain spectral similarity for mapping spoken input to a lexical representation. Our experiments aimed to replicate the anadrome effect and to test the coarse grain similarity account using competitors without vowel position overlap (e.g., competitor leaf for target flea). The results confirmed the original effect: anadrome competitor fixation curves diverged from unrelated distractors approximately 275 ms after the onset of the target word. In contrast, the no vowel position overlap competitor did not show an increase in fixations compared with the unrelated distractors. The contrasting results for the anadrome and no vowel position overlap items are discussed in terms of theoretical implications of sequential match versus coarse grain similarity accounts of spoken word recognition. We also discuss design issues (repetition of stimulus materials and display parameters) concerning the use of the visual world paradigm in making inferences about online spoken word recognition.
The role of orthography in second-language spoken word production: Evidence from Tibetan Chinese bilinguals
Authors: Qu Qingqing , Damian Markus F
Published: April 2019

Evidence suggests that spoken language production involves involuntary access to orthographic representations, both in languages with alphabetic and non-alphabetic scripts. An unexplored question is whether the role of orthography varies as a function of the language being native or non-native to the individual. Native (L1) and non-native (L2) languages differ in important aspects, that is, lexical representations in L2 might be less well established, but acquired at least partly via reading, and these unique features of non-native languages may contribute to a fundamental difference in how spelling and sound interact in production. We investigated an orthographic impact on spoken production with Tibetan Chinese bilinguals who named coloured line drawings of objects with Chinese adjective–noun phrases. Colour and object names were orthographically related or unrelated. Even though none of the participants were aware of the orthographic manipulation, orthographic overlap generated a facilitatory effect. In conjunction with earlier findings from native speakers on the identical task, we conclude that orthographic information is activated in spoken word production regardless of whether the response language is native or non-native.
Measurement of thumb pronation and palmar abduction angles with a small motion sensor: a comparison with Kapandji scores
Authors: Kuroiwa Tomoyuki , Nimura Akimoto , Suzuki Shiro , Sasaki Toru , Okawa Atsushi , Fujita Koji
Published: April 2019

The Kapandji score is used widely to record thumb opposition and is the only alternative to angular measurements. We aimed to verify the extent to which the Kapandji score reflects the angle of pronation. We recruited volunteers with unaffected upper limbs (33 hands) and patients with carpal tunnel syndrome (20 hands). We attached a small gyroscope to the thumb metacarpal and measured the pronation and palmar abduction angles at each position of the Kapandji score in both groups. The Kapandji score showed a strong ceiling effect, and the increase in angle size at each Kapandji score levelled off around a score of 6 in both groups. A Kapandji score greater than 6 does not necessarily reflect thumb opposition.

Level of Evidence: III
Spatial distribution of biopsy cores and the detection of intra-lesion pathologic heterogeneity
Authors: Calio Brian P. , Deshmukh Sandeep , Mitchell Donald , Roth Christopher G. , Calvaresi Anne E. , Hookim Kim , McCue Peter , Trabulsi Edouard J. , Lallas Costas D.
Published: April 2019

Objectives:

The objective of this study was to determine if spatial distribution of multiparametric magnetic resonance imaging–transrectal ultrasound (mpMRI-TRUS) fusion biopsy cores to the index lesion reveals trends in the detection of intra-lesion Gleason heterogeneity and a more optimal prostate biopsy strategy.

Methods:

Index lesion was the lesion with longest diameter on T2-weighted (T2W)-MRI. In cohort 1, fusion biopsy cores biopsies were taken in areas in the center of the target as well as 1 cm laterally on each side. For cohort 2, targeted biopsies were taken from the center of the lesion only. Heterogeneity was defined as difference in maximum Gleason score obtained from fusion cores in the center of the index lesion versus cores obtained from the periphery (cohort 1), or any difference in maximum Gleason score obtained from fusion cores targeted to the index lesion (cohort 2) compared with systematic 12 cores TRUS biopsy.

Results:

Ninety-nine consecutive patients (35 and 64 in cohorts 1 and 2, respectively) with median age (SD) and prostate-specific antigen (PSA) of 66.9 (±5.9) and 9.7 (±8.2) respectively, were included. Age, PSA, Prostate Imaging Reporting and Data System (PI-RADS) score, and preoperative MRI lesion size were not significantly different between cohorts. Gleason heterogeneity was observed at a significantly higher rate in cohort 1 versus cohort 2 (58% versus 24%; p = 0.041). In cohort 1, cores obtained from the center of the lesion had higher Gleason score than cores obtained from the periphery of the targeted lesion in 57% of cases.

Conclusions:

We demonstrate that there is observable tumor heterogeneity in biopsy specimens, and that increased number of cores, as well as cores focused on the center and periphery of the largest lesion in the prostate, provide more comprehensive diagnostic information about the patient’s clinical risk category than taking nonspecific cores targeted within the tumor.
Investigation of the Impact of Below-Knee Compression Garments on Markers of Exercise-Induced Muscle Damage and Performance in Endurance Runners: A Prospective Randomized Controlled Trial
Authors: Geldenhuys A. Grethe , Swart Jeroen , Bosch Andrew
Published: April 2019

Background:

Compression garment utilization is very popular among runners despite a lack of consensus in the literature regarding a beneficial impact. The aim of the study was to investigate the impact of training and competing with compression garments on exercise-induced muscle damage and performance in ultramarathon runners.

Hypothesis:

Compression garments will reduce the severity of exercise-induced muscle damage and improve performance in long-distance runners compared with control conditions.

Study Design:

Prospective, randomized controlled trial.

Level of Evidence:

Level 1.

Methods:

The study was conducted in healthy, uninjured endurance runners (n = 41) participating in a 56-km ultramarathon. The experimental group (n = 20; 14 males, 6 females) trained for 6 weeks and participated in the race wearing below-knee compression garments while the control group (n = 21; 15 males, 6 females) did not. Participants were tested on 4 occasions for various markers of exercise-induced muscle damage and running performance.

Results:

Ankle circumference measurements increased significantly less ( P = 0.01, Cohen d = 0.9) in the experimental group from immediately after until 2 days post-race compared with the control group. No further statistically significant changes were detected over time in midcalf circumferences, muscle architecture, or race performance. Selected pain ratings were statistically significant and worse in the experimental group.

Conclusion:

There are limited indications of a beneficial impact of compression garments with improvements in ankle circumference measurements. No ergogenic impact was detected.

Clinical Relevance:

There is limited evidence to support the continued utilization of commercially available below-knee compression garments during running for the purpose of muscle recovery or as a performance aid.
Regulating worker-customer relations to improve workers’ wellbeing
Authors: Wuytens Chris , De Groof Sarah
Published: April 2019

Recent developments in the gig economy triggered labour law. Platforms change the relationship between customers and workers causing over-subordination of workers. The over-subordination is caused by customers and the surveys they complete to evaluate the worker. The influence of customers over workers can also be seen in a more traditional setting. However, customers are not always king. It is suggested in this article that surveys can be used as an instrument to build decent labour relationships. Installing the measurement of needs measures the impact of customers on workers. By installing a continuous measure of the needs, we have at our disposal an instrument to fulfil labour law’s wellbeing function. Labour legislation could oblige employers to integrate need satisfaction into their customer surveys and their workers surveys. By doing so, technology allows us to make sure that platform work or any kind of work where workers meet high customer demands, become ‘Innovative forms of work that ensure quality working conditions’, as requested by the European Social Pillar.
Surfing the right ventricular pressure waveform: methods to assess global, systolic and diastolic RV function from a clinical right heart catheterization
Authors: Vanderpool Rebecca R. , Puri Reena , Osorio Alexandra , Wickstrom Kelly , Desai Ankit A. , Black Stephen M. , Garcia Joe G.N. , Yuan Jason X.‐J. , Rischard Franz P.
Published: April 2019

Right ventricular (RV) function strongly associates with mortality in patients with pulmonary arterial hypertension (PAH). Current methods to determine RV function require temporal measurements of pressure and volume. The aim of the study was to investigate the feasibility of using right heart catheterization (RHC) measurements to estimate systolic and diastolic RV function. RV pressure and volume points were fit to P = α(eβV‐1) to assess diastolic stiffness coefficient (β) and end‐diastolic elastance (Eed). Single‐beat methods were used to assess RV contractility (Ees). The effects of a non‐zero unstressed RV volume (V0), RHC‐derived stroke volume (SVRHC), and normalization of the end‐diastolic volume (EDV) on estimates of β, Eed, and Ees were tested using Bland–Altman analysis in an incident PAH cohort (n = 32) that had both a RHC and cardiac magnetic resonance (CMR) test. RHC‐derived measures of RV function were used to detect the effect of prostacyclin therapy in an incident PAH cohort and the severity of PAH in prevalent PAH (n = 21). A non‐zero V0 had a minimal effect on β with a small bias and limits of agreement (LOA). Stroke volume (SV) significantly influenced estimates of β and Ees with a large LOA. Normalization of EDV had minimal effect on both β and Eed. RHC‐derived β and Eed increased due to the severity of PAH and decreased due to three months of prostacyclin therapy. It is feasible to detect therapeutic changes in specific stiffness and elastic properties of the RV from signal‐beat pressure‐volume loops by using RHC‐derived SV and normalizing RV EDV.
Unusual melanoma of the scalp with blue nevus-like features and local metastasis: A case report
Authors: George Sheenagh JK , Green Peter , Walsh Noreen MG
Published: April 2019

We present an unusual case of melanoma in a 76-year-old female covering approximately 80% of her scalp. Partial sampling of the lesion revealed focal blue nevus-like features at the microscopic level. We discuss issues related to blue nevus-like melanomas and highlight the unique clinical presentation of the current case.
The Multiple Sclerosis Functional Composite and Symbol Digit Modalities Test as outcome measures in pediatric multiple sclerosis
Authors: Brenton J. Nicholas , Koshiya Hitoshi , Woolbright Emma , Goldman Myla D.
Published: April 2019

Background

There is an increasing number of pediatric multiple sclerosis (MS) clinical trials occurring; however, data validating outcome metrics that accurately capture functional disability within pediatric cohorts are limited.

Objective

The aim of this study was to investigate the ability of the MS Functional Composite (MSFC) and Symbol Digit Modalities Test (SDMT) to distinguish functional disability in pediatric MS patients.

Methods

A total of 20 pediatric MS patients and 40 age and sex-matched controls completed the SDMT and MSFC components: a timed 25-foot walk (T25FW); 9-hole peg test (9HPT); and paced auditory serial addition test (PASAT). Z scores for MS patients were created for each test based on control means. MS patients underwent Expanded Disability Status Scale (EDSS) examination.

Results

Pediatric MS patients exhibited low levels of disability on EDSS, median [range]: 1.5 [1.0–3.0]. Compared with controls, MS patients performed significantly lower on SDMT ( p = 0.0002) and all MSFC components: T25FW ( p = 0.001), 9HPT ( p = 0.01), and PASAT ( p = 0.004). SDMT and MSFC performance were not correlated with EDSS.

Conclusions

Despite low levels of neurologic disability as measured by EDSS, pediatric patients with MS exhibit impaired performance in leg function, upper limb fine motor function, and auditory/visuospatial processing speeds, supporting the value of the MSFC and SDMT in this population. Longitudinal studies are needed to further validate their utility.
Customers’ Expectation, Satisfaction, and Repurchase Intention of Used Products Online: Empirical Evidence From China
Authors: Ashfaq Muhammad , Yun Jiang , Waheed Abdul , Khan Muhammad Shahid , Farrukh Muhammad
Published: April 2019

The trend to shop secondhand products (SHPs) is accelerating owing to a substantial interest of customers particularly toward online shopping of SHPs. Drawing on the expectation–confirmation model (ECM), this study aims to examine the relationships among customer expectation, perceived enjoyment, perceived ease of use (PEOU), satisfaction, and repurchase intention of online shopping of used products. Data were collected using a convenience sampling technique from 400 Chinese shoppers often acquire used products online. The results revealed that expectation significantly affects perceived enjoyment, PEOU, and satisfaction. The findings further reported that perceived enjoyment has a positive influence on satisfaction and repurchase intention. Likewise, satisfaction has a positive direct effect on repurchase intention. Our results affirmed that satisfaction partially mediates the relationships among expectation, perceived enjoyment, and repurchase intention, whereas no mediation established among PEOU, satisfaction, and repurchase intention. Finally, an insignificant effect of PEOU on satisfaction and repurchase intention was observed. The study empirically furnishes insightful information for the organizations to offer SHPs online to enhance organizational profit. Theoretical and managerial implications along with research opportunities are reported.
Patient Participation During Anterior Cruciate Ligament Reconstruction Improves Comprehension, Satisfaction, and Functional Outcomes: A Simple Way to Improve Our Practices
Authors: Courtot Louis , Ferre Fabrice , Reina Nicolas , Marot Vincent , Chiron Philippe , Berard Emilie , Cavaignac Etienne
Published: April 2019

Background:

It is estimated that 28% of patients are dissatisfied after anterior cruciate ligament (ACL) reconstruction, in part because they do not understand the procedure well enough.

Purpose:

To assess the postoperative comprehension, satisfaction, and functional outcomes of 2 patient groups: 1 undergoing a standard surgical procedure (standard group) and 1 involved in their surgery (participation group).

Study Design:

Cohort study; Level of evidence, 2.

Methods:

Over a 4-month period, 62 patients were included: 31 in the standard group and 31 in the participation group. The preoperative information, surgical technique, anesthesia, and postoperative course were identical in both groups. Patients in the participation group were allowed to watch the arthroscopic portion of their surgery live on a video screen, and standardized information was given to these patients during the arthroscopic phase. Self-administered questionnaires were given to assess comprehension (Matava score), satisfaction (visual analog scale [VAS] for satisfaction, Net Promoter Score [NPS], and Evaluation du Vécu de l’Anesthésie LocoRégionale [EVAN-LR]), and outcomes (International Knee Documentation Committee [IKDC] form and Anterior Cruciate Ligament–Return to Sport after Injury [ACL-RSI] scale) between groups.

Results:

Postoperative comprehension was significantly improved in the participation group, as the Matava score increased by a mean of 7.1 ± 5.3 points versus 2.7 ± 5.6 points in the standard group ( P = .0024). The mean VAS satisfaction score immediately after surgery was 9.8 ± 0.6 in the participation group versus 8.9 ± 1.9 in the standard group ( P = .0033); this difference was still present at 1 year postoperatively (9.8 ± 0.6 vs 9.1 ± 1.7, respectively; P = .0145). The NPS was 96.8% in the participation group versus 64.5% in the standard group ( P = .0057) in the immediate postoperative period and 100.0% in the participation group versus 71.0% in the standard group at 1 year postoperatively ( P = .0046). The mean total EVAN-LR score was 89.1 ± 6.5 in the participation group and 84.6 ± 9.9 in the standard group ( P = .0416). At 1 year postoperatively, the mean IKDC score was 86.0 ± 7.5 in the participation group versus 80.0 ± 7.4 in the standard group ( P = .0023). The mean ACL-RSI score was 80.9 ± 7.7 in the participation group versus 74.3 ± 8.4 in the standard group ( P = .0019).

Conclusion:

Involving patients in their ACL reconstruction surgery improves their understanding of the procedure and their satisfaction with their care, which results in better outcomes at 1 year postoperatively.
Predictors of survival in non-metastatic renal cell cancer after surgery: A retrospective analysis
Authors: Zemni Ines , Mansouri Houyem , Haddad Sabrine , Ayadi Mohamed Ali , slimene Maher , Bouzaiene Hatem , Ben Hassouna Jamel , Rahal Khaled
Published: April 2019

Aim:

To investigate the prognostic significance of clinical and pathological factors of non-metastatic renal cell cancer after surgery.

Patients and methods:

We conducted a retrospective cohort study based on the records of patients with non-metastatic renal cancer submitted to radical or partial nephrectomy between 2000 and 2015 in Salah-Azaiez Institute.

Results:

Median follow-up was 38 months (interquartile range: 20–64). Five-year overall and disease-free survival were 53.8% and 43.1%. In the multivariate setting, lymph node invasion (p = 0.01), clear cell renal carcinoma subtype (p = 0.014), and tumor necrosis (p = 0.009) were the only independent statistically significant predictors of disease-free survival, while Fuhrman grade (p = 0.025), clear cell renal carcinoma subtype (p = 0.044), and TNM stage (0.041) were the only factors correlated with overall survival.

Conclusion:

For patients with non-metastatic renal cell carcinoma, independent predictors of disease-free survival and overall survival were clear cell renal cell carcinoma, Fuhrman grade, TNM stage, lymph node invasion, and tumor necrosis. Such information could be used to guide the intensity of follow-up and identify high-risk patients who can be targeted for adjuvant therapy trials.
Protection of Victims in Estonia: A Survey Determining the Status Quo After Implementation of the Directive 2012/29/EU
Authors: Soo Anneli , Espenberg Kerly
Published: April 2019

An online survey was conducted in Estonia among 223 judges, prosecutors, police officers and victim support officers; 223 victims were interviewed via phone and 26 legal professionals (including lawyers) were interviewed face to face with an aim to determine the level of protection of victims after implementation of the Directive 2012/29/EU. The results reveal that victims lack knowledge about their rights although law enforcement agencies are, in general, convinced that they do a good job in this respect. Victims desire criminal proceedings in which they are respected, their opinion is heard and matters, and they are kept informed about developments of the case. The reality, however, does not meet their expectations. As law enforcement agencies are focused on determining guilt of a defendant, victims’ needs fall to the background. There seems to be a dichotomy between the expectations of law enforcement officials and those of the victims: While the latter awaits to be contacted and informed, the officials expect at least certain initiative from victims themselves. The idea that victims should be allowed to speak just to provide them with satisfaction and sense of fair proceedings is still somewhat strange for the authorities. When it comes to sentencing, some state officials believe that the opinions of a victim should not even be asked as determination of the punishment is court’s business. Victims’ opinions are much more readily heard in the conciliation proceedings, which are based on the ideas of restorative justice, but in which defendants’ needs seem to have been forgotten.
Effects of nintedanib in patients with idiopathic pulmonary fibrosis by GAP stage
Authors: Ryerson Christopher J. , Kolb Martin , Richeldi Luca , Lee Joyce , Wachtlin Daniel , Stowasser Susanne , Poletti Venerino
Published: April 2019

We conducted apost hocanalysis to assess the potential impact of GAP (gender, age, physiology) stage on the treatment effect of nintedanib in patients with idiopathic pulmonary fibrosis.

Outcomes were compared in patients at GAP stage IversusII/III at baseline in the INPULSIS® trials.

At baseline, 500 patients were at GAP stage I (nintedanib 304, placebo 196), 489 were at GAP stage II (nintedanib 296, placebo 193) and 71 were at GAP stage III (nintedanib 38, placebo 33). In nintedanib-treated patients, the annual rate of decline in forced vital capacity (FVC) was similar in patients at GAP stage I and GAP stage II/III at baseline (−110.1 and −116.6 mL·year−1, respectively), and in both subgroups was lower than in placebo-treated patients (−218.5 and −227.6 mL·year−1, respectively) (treatment-by-time-by-subgroup interaction p=0.92). In the nintedanib group, the number of deaths was 43.8% of those predicted based on GAP stage (35versus79.9). In the placebo group, the number of deaths was 59.8% of those predicted based on GAP stage (33versus55.2).

In conclusion, data from the INPULSIS® trials suggest that nintedanib has a similar beneficial effect on the rate of FVC decline in patients at GAP stage IversusII/III at baseline.
High-yield isolation of menstrual blood derived endometrial stem cells by direct red blood cell lysis treatment
Authors: Sun Yuliang , Ren Yakun , Yang Fen , He Yanan , Liang Shengying , Guan Lihong , Cheng Fangfang , Liu Yanli , Lin Juntang
Published: April 2019

Recently, menstrual blood-derived endometrial stem cells (MenSCs) have become attractive for stem cell based therapy due to their abundance, easy and non-invasive extraction and isolation process, high proliferative capacity and multi-lineage differentiation potential. MenSC-based therapies for various diseases are being extensively researched. However, the high death rate and poor engraftment in sites of damaged tissues reduce the therapeutic value of these stem cells for transplantation. In theory, periodic stem cell transplantation is an alternative strategy to overcome the challenge of the loss of beneficial stem cell-derived effects due to the rapid disappearance of the stem cells in vivo. However, periodic stem cell transplantation requires sufficient amounts of the desired stem cells with a low number of subculture passages. Our previous results have demonstrated that primary MenSCs mainly reside in the deciduous endometrium, and considerable amounts of deciduous endometrium intertwined with menstrual blood clots were discarded after conventional density gradient centrifugation (DGC). Therefore, the aim of this study was to determine whether primary MenSCs exist in the sedimentation of the deciduous endometrium after DGC and further to evaluate the isolation of MenSCs by direct red blood cell lysis treatment. As expected, our results confirmed that substantial amounts of primary MenSCs still remain in the sedimentation after DGC and indicated that MenSC isolation by directly lysing the red blood cells not only guaranteed substantial amounts of superior MenSCs with a low number of subculture passages, but also was time efficient and economical, providing a solid support for their extensive clinical application.
Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish
Authors: Reuter Isabel , Jäckels Jana , Kneitz Susanne , Kuper Jochen , Lesch Klaus-Peter , Lillesaar Christina
Published: April 2019

In most vertebrates, including zebrafish, the hypothalamic serotonergic cerebrospinal fluid-contacting (CSF-c) cells constitute a prominent population. In contrast to the hindbrain serotonergic neurons, little is known about the development and function of these cells. Here, we identify Fibroblast growth factor (Fgf)3 as the main Fgf ligand controlling the ontogeny of serotonergic CSF-c cells. We show that fgf3 positively regulates the number of serotonergic CSF-c cells, as well as a subset of dopaminergic and neuroendocrine cells in the posterior hypothalamus via control of proliferation and cell survival. Further, expression of the ETS-domain transcription factor etv5b is downregulated after fgf3 impairment. Previous findings identified etv5b as critical for the proliferation of serotonergic progenitors in the hypothalamus, and therefore we now suggest that Fgf3 acts via etv5b during early development to ultimately control the number of mature serotonergic CSF-c cells. Moreover, our analysis of the developing hypothalamic transcriptome shows that the expression of fgf3 is upregulated upon fgf3 loss-of-function, suggesting activation of a self-compensatory mechanism. Together, these results highlight Fgf3 in a novel context as part of a signalling pathway of critical importance for hypothalamic development.
Karyoevolution ofCrenicichlaheckel 1840 (Cichlidae, Perciformes): a process mediated by inversions
Authors: Frade Luan Felipe da Silva , Almeida Bruno Rafael Ribeiro de , Milhomem–Paixão Susana Suely Rodrigues , Ready Jonathan Stuart , Nagamachi Cleusa Yoshiko , Pieczarka Julio Cesar , Noronha Renata Coelho Rodrigues
Published: April 2019

Crenicichla (Cichliformes, Cichlidae) present a highly conserved diploid number 2n=48 with fundamental numbers varying between 52 and 62. We analyzed four species in order to investigate the role of repetitive DNA in chromosome evolution in the genus. C. johanna, C. cf. saxatilis and C. cf. regani have 2n=48 (8m/sm and 40st/a) and FN=56, while Crenicichla sp. “Xingu I” has 2n=48 (48 st/a) and FN=48. Different patterns of constitutive heterochromatin distribution were observed including pericentric, interstitial and whole arm C bands. A single chromosome bears 18S rDNA clusters in most species, except C. johanna, where population variation exists in terms of the quantity and distribution of clusters and their association with interstitial telomeric sequences. All species showed hybridization of 5S rDNA sequences in an interstitial region on an acrocentric chromosome pair. The karyotypic differences and maintenance of the diploid number supports chromosome evolution mediated by inversions in Crenicichla. The telomeric and 18S rDNA sequence association in various chromosomes of C. johanna are proposed to represent hotspots for breakage, favoring intrachromosomal rearrangements. The results suggest that repetitive sequences can contribute to microstructural cytogenetic diversity in Crenicichla.
The moderate effect of analytics capabilities on the service quality
Authors: Vale Laís Rocha , Sincorá Larissa Alves , Milhomem Letícia de Sousa
Published: April 2019

This paper intends to analyze the moderate effect of organizational analytics capabilities in the development and service delivery processes, using as reference the gaps described in the Service Quality Model developed by Parasuraman, Zeithaml and Berry (1985). As a result of the analysis, five theoretical propositions were proposed, which elucidate the existing relationships between analytics capabilities and the Service Quality Model gaps, in order to generate future empirical research.
Deep brain stimulation: new possibilities for the treatment of mental disorders
Authors: Beszłej Jan , Wieczorek Tomasz , Kobyłko Agnieszka , Piotrowski Patryk , Siwicki Damian , Weiser Artur , Fila-Witecka Karolina , Rymaszewska Joanna , Tabakow Paweł
Published: April 2019

Głęboka stymulacja mózgu (ang. Deep Brain Stimulation, DBS) to metoda leczenia, która jest obecnie obiektem coraz większej uwagi ze strony psychiatrów. Udowodniono, że jest skuteczna i bezpieczna w leczeniu zaburzeń neurologicznych, przede wszystkim choroby Parkinsona (PD), dystonii i drżenia samoistnego. DBS bardzo często pozwala na skuteczne leczenie w przypadkach opornych na wszystkie inne metody terapii.
Obecnie oporne na leczenie zaburzenie obsesyjno-kompulsyjne (OCD) pozostaje głównym potwierdzonym zasadami EBM wskazaniem psychiatrycznym dla DBS. Wiele badań koncentruje się na ocenie skuteczności i bezpieczeństwa tej metody w innych zaburzeniach psychicznych, w tym w zaburzeniach depresyjnych, chorobie Alzheimera, jadłowstręcie psychicznym, zespole Tourette'a, uzależnieniu od substancji psychoaktywnych lub zachowaniach agresywnych.W ostatnich latach opisywano również pojedyncze przypadki skutecznego leczenia zaburzenia dwubiegunowego, schizofrenii i zespołu stresu pourazowego. W niniejszym opracowaniu przedstawiono aktualny stan wiedzy na temat przydatności DBS w psychiatrii w oparciu o dostępne przeglądy systematyczne, badania kliniczne i studia przypadków jak również o dane neurofizjologiczne i neuroobrazowe.
Coupling Labor Codes of Conduct and Supplier Labor Practices: The Role of Internal Structural Conditions
Authors: Bird Yanhua , Short Jodi L. , Toffel Michael W.
Published: April 2019

In response to media exposés and activist group pressure to eliminate exploitive working conditions, multinational companies have pushed their suppliers to adopt labor codes of conduct and improve their labor practices to meet the standards set forth in these codes. Yet little is known about the extent to which suppliers are improving their labor practices to conform to codes of conduct, especially in organizations in which legitimacy structures like codes compete with productivity-driving incentive structures. We theorize that the presence of particular internal structures will affect the extent to which suppliers’ labor practices will become more tightly aligned—or coupled—with their formal commitments to adhere to labor codes. Specifically, we theorize high-powered productivity incentives to be associated with less coupling, and being certified to management system standards and having workers’ unions to be associated with more coupling. We also argue that these efficiency and managerial structures will moderate each other’s relationship to coupling, and that certification and unions will each increase the other’s positive association with coupling. Using social audit data on 3,276 suppliers in 55 countries, we find evidence that supports our hypotheses. Our focus on the internal structural composition of suppliers extends the decoupling literature by theorizing and demonstrating conditions under which suppliers’ core organizational functions are likely to be buffered from change by legitimacy structures. Furthermore, our findings suggest important strategic considerations for managers selecting supplier factories and provide key insights for the design of transnational sustainability governance regimes.

The online appendix is available at https://doi.org/10.1287/orsc.2018.1261 .
Adolescent’s use of the Nutrition Information Panel for Food Choice: A Content Validation of Focus Group Discussions
Authors: JEFRYDIN NORSAKIRA , NOR NORAZMIR MD , TALIB RUZITA ABD
Published: April 2019

Qualitative research methods are receiving increasing recognition in healthcare-related studies. Nonetheless, the debate among scholars continues regarding validity in qualitative research; that is, whether the tools, processes, and data used are appropriate. Therefore, this study aims to describe the development and content validation of a focus group discussion (FGD) interview guide, which was utilized to explore practices and factors that influence adolescents’ usage of the Nutrition Information Panel (NIP) for food choices. A methodological study was carried out to assess the content validity of the FGD interview guide through a two-stage process (i.e., development and validation). The FGD interview guide for this study was developed by the researchers following five essential steps: identification of research objectives, selection of topics and questions, development of the guide, expert evaluations, and a pilot test. The developed FGD guide was assessed by five content experts representing a range of disciplines, including nutritionists, academicians, a qualitative researcher, and a teacher. A pilot FGD was conducted using a setting and participant criteria similar to those that will be employed in the main study. The content validity index (CVI) value for the developed FGD guide is 0.938. Seven out of 13 questions were modified based on the experts’ recommendations, such as reviewing an item, splitting it into two if necessary, retaining its original syntax if it was already suitable, or adding some new items. Subsequently, the researchers refined the questions’ wording and structure based on the analysis from the pilot FGD. Probes were also added to several questions to elicit in-depth responses from the participants. The final version of the FGD guide consisted of 13 main items and probes. The content validity of the FGD interview guide used in the pilot study was affirmed by a panel of experts; hence, it was deemed to be a valid instrument for measuring adolescents’ use of the NIP in future studies. Further investigation is needed to improve assessments of procedural knowledge and to test the interview guide in other populations.
Impact of Soaking and Germination Time on Nutritional Composition and Antioxidant Activity of Nigella Sativa
Authors: SURI SHEENAM , KUMAR VIKAS , TANWAR BEENU , GOYAL ANKIT , GAT YOGESH
Published: April 2019

Indian traditional dishes make use of Nigella sativa seeds because of its distinctive aroma and taste but its application is restricted due to its pungent flavour which can be overcome by various methods of processing such as roasting, soaking, germination etc. Soaking and germination has a positive impact on the nutritional, sensorial and phytochemical attributes of Nigella sativa. The current study was carried out to standardize the optimum soaking and germination conditions with improved nutritional, sensorial and phytochemical attributes of seeds. Nigella sativa seeds were soaked for different time duration (0 hr, 6 hr, 12 hr and 18 hr) followed bygermination for0, 7, 9 and 11 days. The soaked and germinated samples were exposed to a temperature of 50ºC for drying till the constant moisture was obtained and analysed for various physiochemical, nutritional and sensory attributes. All the attributes under study were significantly affected by soaking and germination as compared to the control. Comparatively, except the moisture content all the phytochemicals and nutritional attributes decreased significantly from the control sample. Based on the qualitative attributes, soaking done for 18 hours along with 9th day of germination was observed to be the best and can be considered as the optimum condition to maintain the phytochemical to the safe level as well as reducing the antinutritional factors which can further be used for value addition.
Apontamentos sobre a História da Psicologia Social no Brasil
Authors: Cordeiro Mariana Prioli , Spink Mary Jane Paris
Published: April 2019

Neste artigo, buscamos apresentar algumas das abordagens teóricas, grupos de pesquisa e instituições que fizeram e fazem parte do vasto (e diverso) campo da psicologia social brasileira. Para isso, em um primeiro momento, retomamos o modo como a história dessa ciência costuma ser contada - colocando a "crise de referência" da década de 1970 como um importante momento de inflexão, no qual ganham força a oposição ao modelo positivista de ciência e a necessidade de desenvolver abordagens críticas e comprometidas com a transformação social. Em um segundo momento, apresentamos algumas das abordagens teórico-metodológicas desenvolvidas após esse momento de "crise". Mais especificamente, abordamos o desenvolvimento da análise institucional, da psicologia sócio-histórica, da teoria das representações sociais e das abordagens construcionistas.
Outros personagens entraram em cena: o movimento negro e a emergência de uma "política racializada"
Authors: Martins Hildeberto Vieira
Published: April 2019

A finalidade desse artigo é discutir a importância do movimento negro a partir da década de 1930 em decorrência do seu papel político no cenário nacional, ao denunciar a existência do preconceito racial no Brasil e a relação desigual entre brancos e negros. Definimos como pontos de referência desse movimento a criação tanto da Frente Negra Brasileira (FNB), em 1931, como do Teatro Experimental do Negro (TEN), em 1944. As duas organizações em suas análises da situação do negro expuseram essa questão frequentemente em termos marcados por conteúdo psicológico, visando explicar ou resolver sua condição de exclusão. Pretende-se discutir o papel desse movimento na difusão de uma discussão sobre a autoimagem do negro e seu papel social a partir da racialização política do lugar desse sujeito histórico no Brasil.
EXPEDIENTE - v18n4
Authors: Jacó-Vilela Ana Maria , Darriba Vinícius Anciães
Published: April 2019

EXPEDIENTE - v18n4
An Analysis of A Bidirectional School Nurse-Led Text-Messaging Service
Authors: Wales Nicola , Sayer Lynn
Published: April 2019

Aim: To analyse a school nurse led bi-directional text messaging service provided to young people aged 11–19 in two inner London boroughs.

Background: School nurses play a key role in providing early advice and support to the school-aged population. The ability to access a school nurse has been recognised by young people as something that needs to improve and suggestions of being able to text a school nurse have been made. ChatHealth is a bi-directional text messaging system that allows young people aged 11–19 to ask a school nurse for advice and support via an anonymous short messaging system (SMS). Arguably, ChatHealth offers more opportunities than traditional access methods to reach more young people. However, due to the relatively new concept, there is a limited evidence base regarding its effectiveness.

Methods: An audit of documentary data was completed to analyse the uptake and outcomes of ChatHealth in the local area. Content analysis was carried out analysing 26 conversation transcripts and a staff questionnaire was distributed to gain a better understanding of the role of the school nurse delivering ChatHealth.

Findings: The ChatHealth service appears to be proactive in offering an efficient response to a variety of physical, emotional, sexual health and appointment queries, additionally, the uptake of the service has supplemented the established face-to-face contacts. In the local area, emotional health is the most common type of query being received from young people and the topic school nurses feel least confident in responding to. School nurses identify the benefits of ChatHealth in improving young people's access and in enhancing the visibility of the school nursing service and did not identify it as an inconvenience to their current workload.
Helping children cope with a parent's depression
Authors: Thornton Stephanie
Published: April 2019

Parental depression is associated with mental health problems in children and young people. Stephanie Thornton looks at strategies to help support them.
Gangs and knife crime: A national emergency
Authors: Longfield Anne
Published: April 2019

A vital safety net is lost when a child is excluded or off-rolled—and the likelihood of their involvement in gangs and knife crime increases, says Anne Longfield
The effects of mindfulnessbased therapy: Looking for the evidence
Authors: Thornton Stephanie
Published: April 2019

This series provides an overview of a selection of relevant public health research and comments on the findings and methods. Stephanie Thornton discusses research articles on the practice of mindfulness.
Case report: possible opioid-induced hyperalgesia in a cat
Authors: Borland Karla , Garcia Eva Rioja
Published: April 2019

Opioid-induced hyperalgesia is a recognised phenomenon in human medicine and in experimental animal studies. This case report describes a cat that appeared to have an increased nociceptive response when treated with opioids. Withdrawal of opioid analgesia resulted in improvement in the pain score. This case emphasises the need to tailor analgesia to individual cases, consider multi-modal analgesia and alerts veterinary surgeons to the possibility of opioid-induced hyperalgesia.
The implications of social living in cats
Authors: Trevorrow Nicky
Published: April 2019

Feline social behaviour is frequently misunderstood by owners, which can lead to people not meeting the species-specific needs of their cats (Felis sylvestris catus). Despite the fact that cats are adaptable and can at times form social bonds with other cats, it should not be forgotten that cats are not obligate social animals and as a result, regularly suffer from chronic stress associated with close, often forced, proximity to other cats. Cats are predators, but are also, being relatively small, preyed upon and thus are adept at hiding signs of stress. Therefore, subtle signs of conflict with other cats, both within the same household and in the local neighbourhood, are easily and frequently missed by the cat's owner. Veterinary practices are ideally placed to provide education on cats' needs, improve cat welfare and, where necessary, to refer to a Clinical Animal Behaviourist registered with the Animal Behaviour and Training Council (ABTC).
No big deal – or is it?
Authors: Tanuku Purnima
Published: April 2019

Change can be stressful for children, whether it be small things day-to-day or larger transitions such as starting nursery. New resources are aimed at helping teachers and parents to support children.
Marvellous museums
Authors: Davies Sarah
Published: April 2019

Use International Museum Day as a springboard for children to explore the role of museums and think about them as a way to share knowledge and ideas, and preserve memories of the past and present.
‘Let's get a take-away’
Authors: Harries Judith
Published: April 2019

What is children's favourite – a cafe with healthy snacks or a pizza restaurant? Invite them to role-play their favourite eateries and support them to use new vocabulary and learn about the world.