bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Angiogenesis Using Vascular Endothelial Growth Factor
Authors: Ye Lei , Haider Husnain K , Jiang Shu-Jia , Sim Eugene KW
Published: May 2013

Therapeutic angiogenesis using vascular endothelial growth factor can reduce tissue ischemia by simulating the natural process of angiogenesis. Vascular endothelial growth factor not only stimulates endothelial cells to proliferate and migrate, but also mobilizes endothelial progenitor cells and achieves vascular protection. Besides direct administration of angiogenic proteins, plasmids and viral vectors carrying angiogenic genes have been used. Animal experiments have shown promise with evidence of neovascularization and improved perfusion in the target myocardium. Initial phase I and II clinical trials results are encouraging and reflect the potential success of therapeutic angiogenesis as a clinical modality for the treatment of ischemic heart disease. This review discusses the role of vascular endothelial growth factor in therapeutic angiogenesis, along with the problems and considerations of this approach as a treatment strategy.
Factors Affecting Early Exsanguination and Death in Blunt Thoracic Aortic Trauma
Authors: Lancey Robert A , Pezzella A Thomas , Phillips David A
Published: May 2013

The traditional approach to blunt thoracic aortic injuries has been expedient diagnosis and operative repair due to the significant risk of early exsanguination and death in initial survivors. Nonoperative management has been advocated in patients with multiple injuries to reduce the operative mortality. However, specific clinical parameters and diagnostic tests that may predict the risk of early exsanguination and death have yet to be identified. A retrospective analysis of 80 patients with these injuries was undertaken to identify factors associated with early exsanguination or death. Available aortograms were also examined and graded to determine their utility in predicting these outcomes. Early exsanguination and death were found to be associated with low systolic blood pressure on admission and with short duration from injury to diagnosis. Exsanguination was also associated with the total number of lesions in thoracic injuries, and mortality with age greater than 30 years. Aortographic appearance was not found to correlate with either outcome. Patients with blunt thoracic aortic injuries should continue to be managed expediently, with immediate surgical repair if not contraindicated by associated injuries, to avoid early rupture.
Long Term Outcome of Femoropopliteal Bypass for Claudication and Critical Ischemia
Authors: Kobayashi Masayoshi , Hida Kenji , Shikata Hiroo , Sakamoto Shigeru , Matsubara Junichi
Published: May 2013

We performed 167 femoropopliteal bypass surgeries in 151 patients (95 patients underwent above-knee bypass and 56 below-knee bypass) from December 1985 to December 2000 with the use of prosthetic graft or autologous vein graft. We compared primary patency rates between age, sex, graft material, distal anastomotic site and severity of ischemia, considering their survival rates to elucidate the long-term outcome of above-knee and below-knee femoropopliteal bypass. The 10 year patency rate for above-knee bypass was 47.4%, compared to 36.9% for below-knee ( p < 0.01). Better results were found after bypass surgery for claudicants than for critical ischemia ( p < 0.05). With regard to graft material and age categories, there were unexpectedly no statistical differences in either above-knee or below-knee anastomosis. The survival rate at 10 years in claudicants was 51.2%, compared to 15.9% with critical ischemia ( p < 0.01). Mortality was much influenced by ischemic heart disease ( p < 0.002) and the age of patient ( p < 0.05). The results after above-knee bypass had comparable patency, whereas the results after below-knee bypass were disappointing. Below-knee arterial reconstruction for claudicants should be carefully considered and might be recommended only to patients with critical ischemia.
Transventricular Mitral Commissurotomy in Critical Mitral Stenosis during Pregnancy
Authors: Subbarao Kasturi SVK , Nachiappan Muthuraman , Irineu Antao P
Published: May 2013

The management of a pregnant patient with mitral stenosis is a subject of debate with regards to the optimal type of treatment and the time of intervention. We performed trans-ventricular mitral commissurotomy (TVMC) either as an isolated procedure in the second trimester, or in combination with Cesarian section at term. We retrospectively analyzed our experience with TVMC during pregnancy and formulated a protocol for its management. Between January 1987 and April 2002, fifty one patients underwent TVMC for critical mitral stenosis during pregnancy. In 38 patients, elective TVMC was performed during the second trimester, while in 12, it was performed as an initial procedure along with Cesarian section at term. One patient had an emergency TVMC in the second trimester when she presented with intractable acute pulmonary edema. There were no maternal mortalities. Three patients who developed post-operative mitral regurgitation were managed conservatively. Another two patients who developed cerebral embolism with hemiplegia recovered completely without any neurological deficit. There was only one fetal death in a patient where TVMC was performed as an emergency procedure for acute pulmonary edema. We conclude that TVMC in pregnancy is a safe, cost effective alternative in critical mitral stenosis complicating pregnancy.
Early Results and Problems with St. Jude Medical Symmetry Bypass System in Japan
Authors: Kitamura Hideki , Okabayashi Hitoshi , Hanyu Michiya , Nakano Jota , Kono Satoshi , Nomoto Takuya , Nagasawa Atsushi , Sakaguchi Hisashi , Johno Hiroyuki , Matsuo Takehiko
Published: May 2013

The early results of coronary artery grafting with an aortic connector system were assessed in Japanese patients. From May 2002 through April 2003, 24 consecutive patients underwent off-pump coronary artery bypass using an aortic connector system. Another patient was excluded because the saphenous vein was insufficient for the smallest available aortic connector system. Saphenous veins were harvested from the thigh in 17 (70.8%) patients, and from the lower leg in 7. The size of the aortic connector system was 4.5–5.0 mm in 19 (79.2%) patients. Intraoperative epiaortic echo indicated that a side-clamp was contraindicated in 15 cases. Hemostasis was instantaneous in all patients. There were no hospital deaths and no neurologic morbidity. Pre-discharge angiography revealed 100% patency of the anastomoses. Use of the aortic connector system demonstrated excellent early results with low neurologic morbidity even when employed in the context of an atheromatous ascending aorta. However, smaller sizes of the device are required for some Japanese patients.
Evolution of Repaired and Non-Repaired Tricuspid Regurgitation in Rheumatic Mitral Valve Surgery without Severe Pulmonary Hypertension
Authors: Kirali Kaan , Ömeroğlu Suat Nail , Uzun Kemal , Erentuğ Vedat , Bozbuğa Nilgün , Eren Ercan , Balkanay Mehmet , Alp Mete , Yakut Cevat
Published: May 2013

The aim of this study was to evaluate the usefulness of repairing significant tricuspid regurgitation (≥ grade 2) without severe pulmonary hypertension (≤ 50 mm Hg). Between 1993 and June 2001, 88 consecutive patients were operated on for rheumatic mitral valve disease associated with significant tricuspid regurgitation and without severe pulmonary hypertension. The severity of the tricuspid valve disease was assessed by echocardiography. Sixty-three patients had severe (≥ grade 3) tricuspid regurgitation (Group I), and 25 patients had moderate (grade 2) tricuspid regurgitation (Group II). There was no hospital mortality. six patients died during follow-up. The overall actuarial survival rate for 8 years was 92.1% ± 3.1%. Cox proportional hazard regression analysis showed that age ( p = 0.006) and pulmonary complication ( p = 0.01) were associated with increased late mortality. Freedom from death was similar in both groups at 8 years (93.1% ± 3.3% versus 88% ± 8%, p = 0.7). Severe postoperative tricuspid regurgitation (≥ grade 3), caused by the failure of tricuspid repair or leaving the valve untouched, impaired long-term survival after surgery, and actuarial survival was 96.1% ± 2.7% and 83% ± 7.8% at 7 years ( p = 0.048), respectively. Severe tricuspid regurgitation, functional or organic, should be corrected at the time of mitral valve surgery, whereas untouched functional moderate tricuspid regurgitation improves after mitral valve surgery.
Surgical Management of Pulmonary Cavity Associated with Fungus Ball
Authors: Rergkliang Chareonkiat , Chetpaophan Apirak , Chittithavorn Vorawit , Vasinanukorn Prasert
Published: May 2013

Surgery for pulmonary cavity associated with fungus ball is challenged by chronic lung disease. The purpose of this report was to review patient data, operative procedures and results of surgery. This was a retrospective study. Twenty patients were operated on between January 1997 and December 2002. Fourteen (70%) patients were male and the mean age was 46.30 ± 13.10 years (range, 24 to 76 years). The most common underlying pulmonary disorder was tuberculosis (70%). Ninety five percent of the patients had a history of hemoptysis, and 35% presented with massive hemoptysis. Lobectomy was performed in 11 (55%) patients and 6 (30%) patients were operated on by cavernostomy with transposition of muscle flap technique. There was no operative mortality and 8 complications (3 prolonged airleaks, 2 wound infections, 1 postoperative bleeding, 1 seroma and 1 empyema). It was also found that emergency surgery and cavernostomy with transposition of muscle flap compromised the postoperative course. Surgery is very effective in controlling and preventing hemoptysis in patients who have pulmonary cavity associated with fungus ball. Elective surgery and formal pulmonary resection may be the proper option for low risk patients. Cavernostomy with transposition of muscle flap may be suitable for patients who have poor pulmonary reserve.
Atypical Pulmonary Giant Hydatid Cyst as Bilaterally Symmetrical Solitary Cysts
Authors: Rashid Saadia , Fatimi Saulat Hasnain
Published: May 2013

A pulmonary giant hydatid cyst, a special clinical entity, is rare. Our case involves a young patient who presented with a bilaterally symmetrical solitary cyst in each lung, a feature consistent with congenital lung cysts. The radiological and immunological findings were equivocal. A diagnosis of giant hydatid cyst was made intraoperatively and both cysts were removed conservatively. A follow-up showed complete recovery.
Posterior Mediastinal Goiter
Authors: Chong Chee-Fui , Cheah Wei-Keat , Sin Fai-Lam , Wong Poo-Sing
Published: May 2013

Most mediastinal goiters are retrosternally situated in the anterior mediastinal compartment. Posterior mediastinal goiters, either retrotracheal or retroesophageal, are rare. We herein describe a case involving a retrotracheal goiter in the right posterior mediastinum, which was excised using a combined cervico-partial sternotomy and right thoracotomy approach.
Cusp Extension Technique for Bicuspid Aortic Valve in Turner-like Stigmata
Authors: Oshima Yoshihiro , Koto Keiju , Shimazu Chikashi , Misaki Takuro , Ichida Fukiko , Hashimoto Ikuo
Published: May 2013

A 19-year-old girl with bicuspid aortic valve and Turner-like stigmata underwent a successful repair with a cusp extension technique using fresh autologous pericardium for aortic insufficiency. She also had a simultaneous artificial graft replacement for ascending aortic dilatation. Aortic valve function showed no significant stenosis and slight insufficiency 2 years postoperatively. This technique is recommended to avoid a Ross or Ross/Konno procedure because of its ready availability, simplicity and excellent midterm results.
Sutureless Fixation of Temporary Pacing Wire
Authors: Purohit Manoj , Kaarne Markku
Published: May 2013

A simple sutureless technique of fixing ordinary straight insulated temporary pacing wire is described by creating a floret of the insulation of the wire. It can be easily accomplished and reproduced.
Radiofrequency Ablation for Atrial Fibrillation: Different Approaches
Authors: Chiappini Bruno , Di Bartolomeo Roberto , Marinelli Giuseppe
Published: May 2013

The existing literature regarding radiofrequency ablation for the surgical treatment of atrial fibrillation was reviewed, analyzing the early and late results. A MEDLINE search supplemented with a manual bibliographic review was performed for all peer-reviewed English language articles regarding the use of radiofrequency ablation for the treatment of atrial fibrillation. Six studies were identified, with a total of 451 patients. None of the studies was completely randomized. All patients underwent radiofrequency ablation as an adjunct to a variety of cardiac surgical procedures. The hospital mortality rate was 2.7%. The overall survival rate was 97.1%, and freedom from atrial fibrillation was 76.3% ± 5.1% after a mean follow-up period of 13.8 ± 1.9 months. It was concluded that radiofrequency ablation should be considered a safe and effective means to cure atrial fibrillation in patients undergoing open heart surgery.
Growth of Pulmonary Autograft after Ross Operation in Pediatric Patients
Authors: Raja Shahzad G , Pozzi Marco
Published: May 2013

The Ross procedure is being used increasingly to treat aortic valve disease in pediatric patients; however, there is an ongoing dispute about the durability of the autograft. From November 1996 to September 2003, 32 pediatric patients (mean age, 11 ± 4.5 years) underwent the Ross procedure for various aortic valve diseases, using the root replacement technique. Clinical and echocardiographic follow-up was performed early (within 30 days), at 3 to 6 months, and yearly after surgery. There were no perioperative deaths. The patients were followed-up for up to 7 years with a median interval of 36 months. Actuarial survival at 7 years was 96% ± 3% and there was 100% freedom from re-operation for autograft valve dysfunction or any other cause. The autograft annulus and sinus increased significantly in size during follow-up and the increase in size paralleled the increase in body surface area, with no evidence of disproportional dilatation. The hemodynamics at the latest follow-up were also similar to those at the time of discharge after surgery. Pulmonary autograft replacement of the aortic valve appears to be the ideal solution in pediatric patients, because of relatively low operative risk, excellent late valve function, and real potential for growth.
Surgical Closure of Atrial Septal Defect in Children under Two Years of Age
Authors: Parvathy Usha , Balakrishnan Komarakshi R , Ranjith Madathil S , Saldanha Richard , Vakamudi Mahesh
Published: May 2013

Infants with atrial septal defects are seldom symptomatic and usually require elective surgery between 2 and 4 years of age. However a small minority is symptomatic and management at this age has been controversial. This study evaluated surgical closure of atrial septal defect below 2 years of age. Eighteen infants with a mean age of 13.4 ± 5.7 months were operated on for secundum atrial septal defect from 1994 to 2001. Fourteen patients were symptomatic with failure to thrive in 7 and recurrent respiratory infections in 7, one had increasing cardiomegaly, and 3 were operated on early for social reasons. The defect was isolated in 11 patients (61%) and the other 7 (39%) had minor associated lesions requiring additional procedures such as ductal ligation, direct closure of a tiny ventricular septal defect, and inspection of the mitral valve. There were no early or late deaths. The postoperative course was complicated by pulmonary problems in 4 cases. Of the 16 patients available for follow-up, 14 were asymptomatic and 2 were symptomatically improved. Most showed a dramatic improvement in growth and development. These gratifying results indicate that consideration should be given to early surgical closure of atrial septal defect in symptomatic infants.
Off-Pump Coronary Artery Bypass Surgery: Analysis of 5-Year Experience
Authors: Raja Shahzad G , Haider Zulfiqar , Zaman Haider
Published: May 2013

We retrospectively evaluated the perioperative results of off-pump coronary artery bypass surgery performed in our center. Over a 5-year period, 520 patients were operated off-pump through a median sternotomy with the aid of a cardiac stabilizer and retractor. A total of 1,117 distal anastomoses were made with a mean of 2.2 ± 1.0 bypass grafts per patient. Only 12 patients (2.3%) required conversion to cardiopulmonary bypass, while 10 patients (1.9%) were re-operated for bleeding or graft failure. Perioperative myocardial infarction occurred in 10 patients (1.9%), and postoperative stroke in 3 patients (0.6%). The overall operative mortality was 2.5%, while the rate for the 48 patients who had previous bypass surgery was 2.1%. The results show that off-pump coronary surgery produces low mortality and morbidity, even in the treatment of multivessel disease or high-risk patients.
Cardiac Surgery in an Iranian Teaching Hospital: Outcome and Risk Factors
Authors: Hassantash Seyed-Ahmad , Mirpoor Koorosh , Afrakhteh Maryam
Published: May 2013

Cardiac surgery in Iran has been associated with different facilities, equipment and patient populations in comparison to countries from which most of the academic papers used for identification of risk factors related to outcome and subsequent establishment of risk stratification models originate from. During a 15-month period all patients admitted for adult cardiac surgery using cardiopulmonary bypass (CBP) in a university affiliated teaching hospital were enrolled in a prospective study. Appropriate statistical tests were used to analyze data for mortality and morbidity. There were 730 adults (63% male, 37% female), with age ranged from 16 to 82 (mean, 51.4 ± 14.4). A mortality rate of 5.3% and morbidity of 14.8% (major + minor) were observed in the whole group. Factors correlated with mortality were: age ( p = 0.019), emergency surgery ( p < 0.0001), redo cardiac surgery ( p = 0.01), left ventricular (LV) aneurysm ( p < 0.001), presence of catastrophic states ( p < 0.001), low ejection fraction ( p = 0.04), history of hypertension ( p = 0.05), the individual surgeon ( p < 0.0001), and CPB duration ( p < 0.0001). Factors affecting morbidity included: female gender ( p = 0.04), age ( p = 0.03), emergency surgery ( p = 0.001), redo surgery ( p = 0.008), and catastrophic states ( p < 0.001). The mortality in our study group may be compared with reports presented in the literature. Factors such as age, emergency surgery, redo cardiac surgery, and catastrophic states are statistically related to both mortality and morbidity.
Surgery for Active, Culture Negative Endocarditis
Authors: Hasegawa Makiko I , Kyo Shunei , Asano Haruhiko , Imanaka Kazuhito
Published: May 2013

Culture negative infective endocarditis (CNE) poses very difficult problems during treatment. In this study it was found that of 132 surgically treated patients with infective endocarditis, causative organism was not identified in 46 (34.8 %). Pre- and perioperative conditions and clinical results of these patients were evaluated. CNE remained very frequent even in these years, and it did not decrease with time. Antibiotic treatment prior to microbiological examinations was commonly observed (nearly 90% orally, and 70% intravenously). In average, it took more than 2 months to establish the diagnosis of CNE after the onset, and both aortic and mitral valves were affected frequently (19.0 %). New York Heart Association functional class IV was observed significantly more commonly (61.9%) than culture positive patients. Frequencies of prosthetic valve endocarditis (12.2%), periannular abscess (36.3%), and embolism (21.4%) were similar. Infection was fairly controllable before surgery in 43.9% of CNE patients and in-hospital mortality rate was 14.3%, both of which were comparable to those of all culture positive patients. However, recurrence rate was relatively higher (10.0%). The conditions and outcomes of CNE were comparable to Staphylococcal endocarditis in some aspects, and were relatively worse than overall culture positive endocarditis.
Impact of Age on the Results of Coronary Artery Bypass Grafting
Authors: Mortasawi Amir , Arnrich Bert , Walter Jörg , Frerichs Inez , Rosendahl Ulrich , Ennker Jürgen
Published: May 2013

As the average age of patients undergoing cardiac surgery is increasing, the effects of age on the incidence of postoperative complications and 30-day mortality after coronary artery bypass grafting were examined. The EuroSCORE and corresponding age-stripped EuroSCORE were calculated in 6,057 patients who underwent isolated coronary bypass between January 1996 and January 2002. Both EuroSCORE and age-stripped EuroSCORE exhibited a significant increase with age in the whole group of patients and in those who were alive 30 days after surgery. The 30-day mortality and the incidence of postoperative complications increased significantly with age. A significant age-dependent increase in EuroSCORE was found in patients who died within 30 days postoperatively, whereas no age dependence was observed in the age-stripped EuroSCORE. Univariate analysis showed diabetes mellitus and atrial fibrillation to be significant risk factors for 30-day mortality; atrial fibrillation was also found to significantly affect 30-day mortality on multivariate analysis. In view of the increasing co-morbidity and age-dependent organ changes in the elderly, specific preventive and therapeutic measures are needed in this group of patients undergoing cardiac surgery.
Coronary Artery Bypass Grafting with Left Inferior Epigastric Artery as Collateral
Authors: Honjo Osami , Oba Osamu , Shichijo Takeshi , Yunoki Keiji , Inoue Masahiro , Suezawa Takanori
Published: May 2013

We report a case of co-existent coronary and peripheral vascular disease with collaterals to the lower extremities in a 72-year-old female. The patient had triple-vessel coronary artery disease, an occlusion of the bilateral iliac arteries, and the left internal mammary-inferior epigastric artery collateral pathway was a major route to the lower extremities. Coronary artery bypass grafting and right axillo-bifemoral bypass were performed. The well-developed left inferior epigastric artery was used as a conduit to the circumflex artery.
Triple Valve Replacement with Carpentier-Edwards Bioprostheses
Authors: Guhathakurta Soma , Cherian Kotturathu M
Published: May 2013

We report a unique case of triple valve replacement with porcine bioprostheses in a young woman who remained asymptomatic 15 years later. Although in atrial fibrillation, she was taking only aspirin for anticoagulation until she delivered a normal child 2 years after surgery. Surprisingly, to date, her echocardiographic findings have remained the same as those after childbirth, and all the bioprostheses were functioning well, except for tricuspid annular calcification producing mild to moderate regurgitation.
Surgical Repair of Double Aortic Arch: 16-Year Experience
Authors: Shanmugam Ganesh , Macarthur Kenneth , Pollock James
Published: May 2013

Double aortic arch (DAA) is a complete form of vascular ring causing tracheoesophageal compression. We analyzed long-term results of a series of DAAs, over a period of 16 years. Between 1987 and 2003, 29 children underwent surgery for airway and/or esophageal compression secondary to a DAA. Dominant symptoms were stridor, dysphagia, choking episodes, and life-threatening apneic spells ( n = 7). Diagnosis was established by barium studies, bronchoscopy, echocardiogram, angiogram, computed tomography (CT), and magnetic resonance imaging (MRI). Seven patients had concurrent cardiac anomalies. Two children had an associated tracheoesophageal fistula. Surgery was accomplished by left thoracotomy ( n = 25), right thoracotomy ( n = 2) or median sternotomy ( n = 2). The operative mortality was zero. There was one late death due to respiratory failure. Four (13.8%) patients had a surgical complication (chylothorax, 3 cases; acute renal failure, 1 case). Follow-up (mean 7.1 years; range 6 months to 16 years) was complete in all patients, and showed complete improvement in 22 patients and partial improvement in 6 patients. Early surgical repair of DAA is associated with low mortality, and results in marked symptomatic relief in most patients. Patients with tracheomalacia or associated asthma, constitute a high-risk group and may manifest persistent symptoms and require adjunctive procedures.
Myocardial Oxygen Consumption Index in Patients with Coronary Artery Disease
Authors: Arya Arash , Maleki Majid , Noohi Fereydoon , Kassaian Ebrahim , Roshanali Farideh
Published: May 2013

One hundred and thirty-six men with coronary artery disease were randomly assigned to a hospital-based or home-based exercise program of 3 sessions per week. A treadmill test was carried out with the modified Naughton protocol. After 3 months, 125 patients (92%) with a mean age of 55 ± 11 years had completed the study. Maximum workload achieved increased by 65% [(12.40 ± 1.32 vs. 7.50 ± 0.85 metabolic equivalent units (METs)] in the hospital-based group, and by 17% (8.86 ± 0.9 vs. 7.56 ± 0.78 METs) in the home-based group ( p = 0.0001). The heart rate-blood pressure product, an index of myocardial oxygen consumption, decreased at rest by 19% in the hospital-based group but was unchanged in the home-based group ( p = 0.0001). The heart rate-blood pressure product at 5 and 7 METs activity level decreased 28% and 26%, respectively, in the hospital-based group vs. 8% and 2% in the home-based group ( p = 0.0001). It was concluded that hospital-based exercise training in patients with coronary artery disease improves functional capacity and decreases the myocardial oxygen consumption index at rest and during exercise.
Minimal Access via Lower Partial Sternotomy for Congenital Heart Defects
Authors: Nishigaki Kyoichi , Nishi Hiroyuki , Kume Yoichi , Kitabayashi Katsukiyo , Miyamoto Katsuhiko
Published: May 2013

To evaluate the invasiveness of a minimal access approach for simple congenital heart defects, and determine whether it can be regarded as a standard operation, 83 patients with an atrial septal defect and 73 with a ventricular septal defect underwent repair through a minimal skin incision and lower partial median sternotomy. There were no operative deaths, severe intraoperative complications, or conversion to full sternotomy. The clinical course of 106 patients was compared with that of 21 treated using a full sternotomy by the same surgeon; there were no significant differences, except in the operative time for ASD patients. The clinical courses of 2 minimal access subgroups (50 patients operated on by residents and 106 treated by the staff surgeon were compared; operative time, bypass time, ventricular fibrillation time (ASD repair), and cardiac arrest time (VSD repair) were significantly shorter in those operated on by the staff surgeon, but there was no difference in clinical course. The minimal access approach produced good cosmetic results, its invasiveness was similar to that of a full sternotomy, and it may be considered a standard operation for pediatric patients with septal defects.
Advantages of the Ultrasonic Harmonic Scalpel for Radial Artery Harvesting
Authors: Georghiou Georgios P , Stamler Alon , Berman Marius , Sharoni Erez , Vidne Bernardo A , Sahar Gideon
Published: May 2013

The aim of the study was to examine the safety and effectiveness of the Harmonic Scalpel® for reducing spasm caused by thermal injury during radial artery harvesting. The study sample included 100 candidates undergoing coronary artery bypass grafting. In half the patients, radial artery harvesting was performed using the ultrasonic Harmonic Scalpel equipped with coagulating curved shears and a 14 cm scissor-grip handle and in the other half, hemostatic clips, scissors, and minimal electrocautery were employed. Comparison of outcome between the groups showed that radial artery harvesting with the Harmonic Scalpel was associated with a shorter harvesting time, lower frequency of spasm, larger internal diameter of the radial artery graft, and a significantly reduced need for clips to control bleeding than the standard method. In addition, there were no cases of hematoma or superficial wound infection in the arm, and no postoperative reduction in soft touch sensation or objective pin-prick sensation. In conclusion, the Harmonic Scalpel provides excellent control of bleeding without the need for potentially damaging electrocautery, and with a markedly decreased use of hemostatic clips. Harvesting time is also shorter. The minimized thermal injury decreases the rate of radial artery spasm. Further studies using additional objective measures are currently underway to confirm these findings.
An Alternative and Safer Method for Aortic Decannulation
Authors: Kalkat Maninder S , Parmar Jitender M
Published: May 2013

The removal of an aortic cannula at the termination of cardiopulmonary bypass is occasionally associated with complications like bleeding, atheroembolism and dissection. An alternative method to decannulate using a side-biting non-crushing clamp is suggested to mitigate against these complications.
Reappraisal of Recent Clinical Trials of Angiogenic Therapy in Myocardial Ischemia
Authors: Teng Carolyn J , Lachapelle Kevin , Chiu Ray CJ
Published: May 2013

We review the clinical trials of angiogenic therapy for myocardial ischemia, focusing on why the results are unsatisfactory in more recent larger and better designed trials. Critical reappraisal of such trials, in view of the pathophysiologic complexity of the angiogenic process at a molecular level, suggests that the strategy of therapies based on a single growth factor protein or gene may not be adequate for optimal therapeutic response.
Penetrating Chest Trauma in Nigeria
Authors: Thomas Martins O , Ogunleye Ezekiel O
Published: May 2013

Penetrating chest trauma occurs worldwide, and various accounts of it have been reported in the literature. 1 – 5 Blunt trauma is not usually associated with military or civilian violence, while penetrating chest trauma often is. Penetrating chest trauma is frequently caused by gunshots and non gunshot-related incidents such as stabs, traffic accidents, and impalements. This prospective study was conducted to determine a pattern of penetrating thoracic injuries, including their causes, the role of surgery, and intervention outcomes. In this study, we treated 168 patients (142 males and 26 females, giving a male-to-female ratio of 5.5:1). Gunshots caused 60.1% of the injuries while traffic accidents caused 27.3% of the injuries. Chest tube insertion alone was the main treatment initiated. This technique was used on 73.8% of the patients. To reduce the occurrence of penetrating chest trauma in Lagos, Nigeria, study results suggest that the Nigerian people and their property need greater security, and that pre-hospital level of care for trauma victims must improve.
Effects of Giant Left Atrium on Thromboembolism after Mitral Valve Replacement
Authors: Kutay Veysel , Kirali Kaan , Ekim Hasan , Yakut Cevat
Published: May 2013

The aim of this study was to evaluate the incidence of thromboembolic events in patients with giant left atrium (> 6.5 cm) after mitral valve replacement. From January 2000 to September 2002, a total of 126 patients who had undergone mitral valve replacement were divided into two groups according to the presence or absence of giant left atrium. Group A comprised 34 patients with left atrium over 6.5 cm without compression symptoms and Group B comprised 92 patients. The preoperative variables did not distinguish the patients in each group, except for atrial fibrillation; Group A 85.2% and Group B 61.9% (p < 0.01). After mitral valve replacement, left atrium mean diameter was significantly decreased in Group A from 8.1 ± 1.3 mm to 6.2 ± 1.6 mm ( p < 0.01). There were no significant differences in thrombosis, hemorrhage and thromboembolism rates in both groups. Postoperative clinical and hemodynamic parameters demonstrated a positive clinical response to mitral valve replacement in patients with giant left atrium. During follow-up no direct relationship between thromboembolism and giant left atrium was evident.
Stentless vs. Stented Aortic Valve Replacement: Left Ventricular Mass Regression
Authors: Tamim Muhammed , Bové Thierry , Van Belleghem Yves , François Katrien , Taeymans Yves , Van Nooten Guido J
Published: May 2013

The aim of this retrospective study was to evaluate the time-related regression of left ventricular hypertrophy after stentless vs. stented aortic valve replacement. From January 1992 to December 2002, 145 patients had a Toronto stentless porcine valve and 106 had a stented Carpentier-Edwards aortic valve replacement. Over a 10-year follow-up, survival was superior in the Toronto group vs. the Carpentier-Edwards group (84% vs. 74% at 4 years; 78% vs. 68% at 6 years; p < 0.001). A significant and constant reduction of peak and mean transvalvular gradients after valve replacement resulted in substantial regression of left ventricular mass index in both groups, which did not reach statistical significance. However, this phenomenon stopped at 3 years, and left ventricular mass index increased slowly after 5 years. Stentless and stented bioprostheses both showed good early and late clinical and hemodynamic outcomes, with the advantage of better midterm survival for stentless xenografts.
Corynebacterium Diphtheriae Endocarditis - Surgery for Some but Not All!
Authors: Mishra Bashisth , Dignan Rebecca J , Hughes Clifford F , Hendel Nick
Published: May 2013

Corynebacterium diphtheriae endocarditis was thought to be a rare disease. We reviewed our experience in four cases of this disease treated over a period of 10 years. Seventy cases reported in literature were reviewed. The outcome is good if cases are carefully selected for medical or surgical treatment. We conclude that infective endocarditis due to C. diphtheriae, is perhaps more common than expected. It may be recognized more frequently and on occasion may be an aggressive disease. Those patients with an abnormal valve (including prosthetic valves) should be subjected to surgery at the earliest available opportunity, whereas patients with normal valves may be carefully watched during the course of medical treatment as long as immediate surgery can occur if needed.
Double-Chambered Right Ventricle in Adulthood
Authors: Nagashima Mitsugi , Tomino Tetsuo , Satoh Harumitsu , Nakata Tatsuhiro , Ohtani Takashi , Saito Hiroyuki
Published: May 2013

Patients with double-chambered right ventricle presenting with symptoms in adulthood are rare. From 1990 to 2004, 4 adults and 9 children with double-chambered right ventricle underwent surgical correction. The surgical results and clinical data of the adults were compared with those of the pediatric patients. All adult patients had dyspnea on exertion, 3 children showed growth delay but the others were asymptomatic. The mean age at operation was 44.5 ± 6.3 years in adults and 5.2 ± 1.9 years in children. The mean pressure gradient between the anatomically lower right ventricle and the pulmonary artery was significantly higher in adults than in children (91.8 ± 14.1 vs. 42.2 ± 5.9 mm Hg). The pulmonary-to-systemic flow ratio in adults was significantly lower than in pediatric patients (1.2 ± 0.2 vs. 1.8 ± 0.3). All adults and 8 of the 9 children survived. There were no late deaths or re-operations, and all survivors were in New York Heart Association functional class I. Surgical correction of double-chambered right ventricle in adults gave satisfactory midterm results although right ventricular outflow tract obstruction and clinical symptoms were severe in these patients.
Direct Complications of Repeat Median Sternotomy in Adults
Authors: Elahi Maqsood , Dhannapuneni Ramanarao , Firmin Richard , Hickey Mark
Published: May 2013

Whilst the potential risk to underlying vital structures from redo-sternotomy is well recognized, the actual risk is poorly quantified. Our aim was to determine the incidence of complications directly attributable to redo-sternotomy and to ascertain whether the use of femoro-femoral CPB (FF) prior to redo-sternotomy alters operative morbidity and mortality. Case notes of 185 patients undergoing cardiac surgery necessitating redo-sternotomy between May 1998 and November 2002 were reviewed. Of 121 males and 64 females, the median age was 65.5 years (range 60.1–75 years). Elective FF was performed in 71 (38.3%) of cases and 114 (60%) were performed without the aid of prior femoro-femoral CPB (WFF). Three (1.6%) patients initially planned for WFF were converted to emergency FF due to serious complications. Complications directly attributable to redo-sternotomy occurred in 21 (11.3%) cases; 12 (16.9%) in the FF group and 9 (5.3%) in the WFF group. Overall mortality was 1.6%. In summary, our results suggest that morbidity risk for the operation increases significantly with redo-sternotomy alone. Three deaths in our series from direct complications attributable to redo-sternotomy signify an added risk. Hence the necessity for careful surgical technique and judicious use of elective FF-CPB is emphasized.
Active Thermoregulation Improves Outcome of Off-Pump Coronary Artery Bypass
Authors: Woo Y Joseph , Atluri Pavan , Grand Todd J , Hsu Vivian M , Cheung Albert
Published: May 2013

During off-pump coronary artery bypass grafting, hypothermia increases vasoconstriction, myocardial afterload, coagulopathy and postoperative bleeding. Traditional thermoregulatory techniques do not maintain core body temperature intraoperatively. The efficacy of a commercially available, computer-controlled, water-circulating, dorsal surface, active warming system for thermoregulatory control was evaluated. All patients who underwent non-emergency off-pump coronary bypass grafting by a single surgeon in a 1-year period were studied: the thermoregulation device was used in 50 cases and unavailable for use in 19. The patients who underwent active thermoregulation demonstrated significantly improved core body temperatures compared to the controls: lowest intraoperative, 35.8°C ± 0.1°C vs. 35.0°C ± 0.2°C; immediately postoperative, 36.5°C ± 0.1°C vs. 35.6°C ± 0.2°C; and 1-hour postoperative, 36.6°C ± 0.1°C vs. 35.9°C ± 0.2°C. Thermoregulated patients had significantly reduced 24-hour chest tube drainage (764 ± 38 vs. 1227 ± 183 mL), packed red blood cell transfusions (1.4 ± 0.2 vs. 3.3 ± 0.7 units), time to extubation (6.8 ± 0.5 vs. 11.4 ± 2.3 hours), intensive care unit stay (1.3 ± 0.1 vs. 2.0 ± 0.3 days), and hospital stay (4.3 ± 0.1 vs. 5.1 ± 0.3 days).
Sequential Radial Artery Grafting Three-Vessel Coronary Artery Disease
Authors: Akıncı Esat , Erentug Vedat , Uzun Kemal , Polat Adil , Göksedef Deniz , Yakut Cevat
Published: May 2013

Our objective was to compare the results of revascularization by sequential radial artery (RA) grafting with a left anterior descending left internal mammary artery (LIMA)-RA t-composite grafting technique. Patients were grouped as those with proximal anastomoses performed on the ascending aorta (Group A; n = 38), and those with proximal anastomoses performed on the LIMA as t-grafts (Group T; n = 13). Neither of the two groups revealed any mortality. The average number of grafts was lower in Group T (2.23 ± 0.43 in group T and 2.85 ± 0.69 in group A, p < 0.05). The results of the control coronary artery angiographies were superior in Group A. The patency rate of the RA grafts was 96.8% in Group A. Of the 20 distal anastomoses performed with RA grafts in 8 patients from Group T, nine (45%) were found to be patent. The patency rates of RA grafts with sequential distal anastomoses were found to be better when the proximal anastomosis was performed on the ascending aorta rather than on the LIMA. In conclusion, sequential distal anastomosis of RA grafts seem to be safe and effective when proximal anastomoses are performed on the ascending aorta.
Limitation of Venoarterial Bypass. Early Predictor and Optimal Conversion
Authors: Oishi Yasuhisa , Masuda Munetaka , Imasaka Ken-ichi , Morita Shigeki , Yasui Hisataka
Published: May 2013

Conversion from venoarterial bypass to a ventricular assist device may be lifesaving for patients with severe heart failure, but the criteria for conversion have not yet been established. Forty patients who underwent venoarterial bypass for cardiac failure were reviewed. Of these, 18 (45%) could be weaned from venoarterial bypass, and 11 survived for more than 30 days after weaning (survival rate, 27.5%). Liver dysfunction, renal dysfunction, and the need for left-sided cardiac venting were risk factors for mortality. The appearance of patient's own cardiac pulse wave within 24 hours after the introduction of venoarterial bypass was a good indication for weaning. Delayed appearance of the cardiac pulse wave was considered to be a risk factor for death. According to these indices, conversion from venoarterial bypass to a ventricular assist device should be considered to prevent deterioration in the function of systemic organs.
Lung Resection for Multidrug-Resistant Tuberculosis
Authors: Naidoo Rishen , Reddi Anu
Published: May 2013

The emergence of multidrug-resistant tuberculosis poses a serious challenge to traditional drug therapy. In view of the relapse rate of up to 50% following medical management, there has been renewed interest in the role of surgery for this problem. We report our experience with lung resection for this condition. Over a 5-year period, resection was performed in 23 patients who were diagnosed with multidrug resistance after completing a course of standard chemotherapy and at least 3 months of second-line therapy. Pneumonectomy was performed in 17 patients and lobectomy in 6. There was no operative or postoperative mortality. Major complications developed in 4 patients (17.4%): 2 had post-pneumonectomy empyema and 2 underwent rethoracotomy for bleeding. Ten patients were sputum positive preoperatively, and only 1 remained positive after surgery. The patients were put on appropriate chemotherapy and followed up for 18 months. The cure rate was 95.6%. Pulmonary resection can be considered as an important adjunct to medical therapy in carefully selected patients: those who have localized disease with adequate pulmonary reserve, or who have multiple previous relapses, or whose sputum remains positive after 4 to 6 months of appropriate medical treatment. Surgery offers high cure rates with acceptable morbidity and mortality.
Silicone Airway Stent for Treating Benign Tracheoesophageal Fistula
Authors: Liu Yun-Hen , Ko Po-Jen , Wu Yi-Cheng , Liu Hui-Ping , Tsai Ying-Huang
Published: May 2013

We used a silicone tracheal stent successfully to seal a huge benign tracheoesophageal fistula and restore airway patency after treatment with double metallic stenting of the trachea and esophagus failed. The patient was weaned from the ventilator 16 days after the procedure and after 7 months of ventilatory support.
Mitral Valve Repair and Cryo-Maze Procedure in Ehlers-Danlos Syndrome
Authors: Goto Tomoyuki , Kobayashi Junjiro , Nakajima Hiroyuki , Niwaya Kazuo , Tagusari Osamu , Kitamura Soichiro
Published: May 2013

A 48-year-old man presented with typical features of Ehlers-Danlos syndrome, such as soft and hyperextensible skin, subcutaneous nodules, clubbed feet, and a mild degree of pigeon chest. In addition, his past history revealed congenital dislocation of the hip joint, retinal detachment, and repeated episodes of congestive heart failure due to severe mitral regurgitation and atrial fibrillation. We subjected the patient to surgical repair of the mitral valve combined with the maze procedure, which proved successful.
Two-Chamber Intracardiac Mesothelioma
Authors: Ashrafian Hutan , Athanasiou Thanos , Yap John , DeSouza Anthony C
Published: May 2013

Primary intracardiac malignant mesotheliomas are extremely rare and carry a very poor prognosis. We present such a case where the lesion encompassed two chambers, the left atrium and ventricle, with no pericardial involvement. Initial echocardiography mimicked a myxoma, and urgent surgical intervention was required in view of significant cardiorespiratory compromise. To the best of our knowledge this is the first case of a primary two-chamber intracardiac malignant sarcomatoid mesothelioma.
Outcomes after Arterial Switch Operation for Simple Transposition
Authors: Raja Shahzad G , Shauq Arjamand , Kaarne Markku
Published: May 2013

Without intervention, babies born with transposed great arteries (TGA) are doomed to a rapid death. Jatene and coworkers deserve the credit for performing the first successful arterial switch operation (ASO) in a patient with TGA and ventricular septal defect (VSD) in 1975. Since then ASO has become the procedure of choice in most medical centers. This review article summarizes the historical aspects of arterial switch operation and assesses this procedure's outcomes.
Repair of Anomalous Pulmonary Artery with Interposition Graft: Midterm Results
Authors: Levy Eli , Milgalter Eli , Nir Amiram , Rein Azaria JJT
Published: May 2013

Anomalous pulmonary artery arising from the aorta is a rare congenital anomaly. The midterm results of repair of this malformation by Gore-Tex graft interposition were examined in 5 patients: 3 with anomalous right pulmonary artery and 2 with anomalous left pulmonary artery from the ascending aorta. Echocardiography was adequate in 4 cases for diagnosis, planning the operation, and follow-up. Angiography was needed for diagnosis in one case where the echocardiographic findings were unclear. The mean follow-up period was 4 years. One patient with tracheoesophageal fistula and cardiac malformation died 2 months after the operation due to multi-organ failure. Three patients needed re-operation because of graft narrowing, and one was without problems 5.2 years postoperatively. In anomalous pulmonary artery from the ascending aorta, repair should be performed as early as possible to prevent pulmonary hypertensive changes. When the anomalous pulmonary artery cannot be anastomosed directly to the main pulmonary artery, an interposition graft can be placed safely without cardiopulmonary bypass. With appropriate follow-up, this can be a satisfactory solution, although it carries the risk of re-operation due to graft narrowing.
Total Cavopulmonary Connection with Off-Pump Technique
Authors: Xu Jian-Ping , Luo Xin-Jin , Chu Jun-Ming , Li Shou-Jun , Liu Ying-Long
Published: May 2013

The aim of this study was to evaluate an off-pump technique for total cavopulmonary connection. Between May 2000 and June 2004, 16 patients underwent total cavopulmonary connection without cardiopulmonary bypass. There were 8 males and 8 females, with a mean age of 9.8 ± 6.2 years and a mean weight of 27.7 ± 14.9 kg. Preoperative percutaneous oxygen saturation was 75% ± 6%, and pulmonary arterial pressure was 12.6 ± 2.7 mm Hg. Postoperative outcomes were retrospectively compared with a group of 17 patients who underwent total cavopulmonary connection with an extracardiac conduit under cardiopulmonary bypass. Two patients died early postoperatively. Chylothorax occurred in 2 patients and 3 underwent reoperation for fenestration between the extracardiac conduit and the right atrium in the early postoperative period. All survivors were acyanotic. On discharge from hospital, the percutaneous oxygen saturation breathing air was 95% ± 3%. Patients in the off-pump group demonstrated significantly shorter extubation time and intensive care unit stay. This connection technique is easy to perform and helpful in the early management of patients with a functional univentricular heart. However, much remains to be learned about this unique physiologic system.