bluuebunny/crossref_metadata_2025 huggingface dataset:
Organization and organizing in revolutionary times: The case of Tunisian General Labor Union
Authors: Yousfi Hèla
Published: June 2021

Adopting Barker’s (2011) Marxist approach of a social movement “as a whole”, this article addresses the question of whether and how mass-membership movement organizations can break out of oligarchic authority and support a radical political protest movement. Using an ethnographic approach, this article explores how the UGTT (the Tunisian General Labor Union) responded to organizational challenges during the Tunisian popular uprising in 2010 by examining its intra-organizational processes as well as its interactions with other parts of the protest movement and how their struggles mutually aided the fall of Ben Ali’s regime. The findings highlight that two correlated aspects were critical to a radical transformation of UGTT’s conservative goal. First, unionists with activism experience outside the labor organization played a key role as “mediators,” deriving meaning from the organizational culture of the union to interpret the course of the event, supporting the popular uprising, and forcing the union leadership to join the revolutionary process. Second, the unpredictable and unprecedented regime repression radicalized the protest movement and its claims, and ruptured the union’s traditional bureaucracy. The article concludes by elaborating on the potential of organizational studies to help us understand the role of trade unions in protest movement organizing and, more broadly, the role of formal mass-membership organizations in social movements.
Accuracy incentives and framing effects to minimize the influence of cognitive bias among advanced cancer patients
Authors: Finkelstein Eric A , Cheung Yin Bun , Schweitzer Maurice E , Lee Lai Heng , Kanesvaran Ravindran , Baid Drishti
Published: June 2021

Many patients with advanced illness have unrealistic survival expectations, largely due to cognitive biases. Studies suggests that when people are motivated to be accurate, they are less prone to succumb to these biases. Using a randomized survey design, we test whether offering advanced cancer patients ( n = 200) incentives to estimate their prognosis improves accuracy. We also test whether presenting treatment benefits in terms of a loss (mortality) rather than a gain (survival) reduces willingness to take up a hypothetical treatment. Results are not consistent with the proposed hypotheses for either accuracy incentives or framing effects.
Beyond a Dichotomous Understanding of Online Anonymity: Bridging the Macro and Micro Level
Authors: Eklund Lina , von Essen Emma , Jonsson Fatima , Johansson Magnus
Published: June 2021

Anonymity on the Internet is a contentious issue; by some seen as an important freedom to be protected, while others argue for increased identification to protect groups at risk of exploitation. The debate reflects a dichotomous view of online anonymity; you are, or you are not anonymous. However, anonymity is a complex process played out on different levels and defined by various actors. While empirical studies show this, theoretical synthesis is lacking. This essay provides perspective on anonymity online by comparing two critical cases, online auctions and online gaming, we corroborate results from a 4-year interdisciplinary project with researchers from sociology, economics, and computer and system sciences. We argue that one should talk about anonymities in plural form, as online anonymity is not a state but a relational process. We put forth a conceptual model, which unpacks online anonymity as interdependent macro structures – legal, commercial, and technological – and micro/meso facets – factual, social group, and physical – to be used in future research.
A different kind of emancipation? From lifestyle to form-of-life
Authors: Pellizzoni Luigi
Published: June 2021

The modern outlook on emancipation has made its quest inseparable from a quest for endless enhancement, based on an ever-more intensive exploitation of the biophysical world. This accounts for how unsustainable ways of living are reiterated worldwide, in spite of evidence of their deleterious effects. The underpinnings of unsustainability, and a major impediment to conceiving alternatives, come from an account of the human as ontologically indeterminate, crushed on doing, both vulnerable and powerful towards the world. The impasse of such ambivalence hampers social theory critique, from post-humanist ontologies to the case for degrowth and lifestyle politics. The article outlines a different take on emancipation. An account is provided of form-of-life as a doing tailored to being – not as a self-enclosed monad but as a result of the encounter between own ‘inclination’ and the world. This theoretical perspective discloses a research program on emergent mobilisations.
One Health practices across key agencies in Sweden – Uncovering barriers to cooperation, communication and coordination
Authors: Humboldt-Dachroeden Sarah
Published: June 2021

Aim:

This study examined the barriers and opportunities in Sweden for integrating One Health practices. Sweden’s long tradition of working with One Health was used as a case to analyse persistent barriers as well as opportunities.

Method:

Thirteen semi-structured interviews with experts from the Swedish Veterinary Agency, Food Agency, Public Health Agency, and Environmental Protection Agency were carried out. A thematic content analysis was conducted on the interviews using inductive coding in NVivo.

Results:

The study revealed that while collaboration is the general aspiration across the Swedish agencies, barriers persist regarding the understanding of One Health, the integration of the environment sector and awareness of the different terminologies employed within the disciplines. There are legislative challenges and barriers to science to policy translation. Disease outbreak was identified as an opportunity for One Health integration.

Conclusions:

A One Health strategy needs to be developed at agency level to define One Health and clarify the roles and responsibilities. To overcome practical challenges, experts need to be aware of different terminologies and practices when collaborating. Further prospects for One Health integration include employing policy entrepreneurs to push One Health onto the political agenda. Preparations for disease outbreaks need to focus on reducing barriers to effectively integrate One Health. Experiences of One Health projects must be disseminated, and to raise awareness, education programmes must integrate One Health into curricula.
The impact of media use on the spillover and crossover effect of couple conflict
Authors: Kashian Nicole
Published: June 2021

This 5-day daily diary study examined the influence of media use on the spillover and crossover effect of couple conflict among married and dating couples. Couples aged 18–38 years recorded their daily overload, negative mood, couple conflict, media use, flooding, and satisfaction. The results showed negative spillover and crossover effects: individuals reported more negative moods and couple conflict in response to their own and their partners’ increase in daily overload. Following media synchronicity theory, the more synchronous media couples used in conflict, the more they resolved the conflict. In addition, the more couples segmented their channels, the less they flooded and the more they resolved the conflict. The results suggest that dating and married couples might benefit from managing conflict associated with spillover and crossover effects using synchronous channels that are segmented.
IQ and digital inequality: An empirical investigation
Authors: van Deursen Alexander JAM , van Dijk Jan AGM
Published: June 2021

Cognitive intelligence is rarely discussed in the context of digital inequality for practical and normative reasons: substantial difficulties around measurements and the fact that it cannot (easily) be changed. In the current contribution, cognitive intelligence is studied in relation to resources and appropriation theory which explains digital inequality as a process of four successive phases of Internet access: motivational, material, skills, and usage. For the measurement of cognitive intelligence, we build on considerable efforts devoted to developing alternatives to cumbersome intelligence quotient (IQ) tests of intelligence. We conducted a two-wave online survey in the Netherlands, resulting in a sample of 1733 respondents. The importance of IQ was confirmed with direct positive effects on education, economic, social, and cultural resources, and on Internet attitude and skills. The results reveal several details that can enhance our understanding of the specific mechanisms through which IQ and education operate in digital inequalities.
Criminogenic risk assessment: A meta-review and critical analysis
Authors: Prins Seth J , Reich Adam
Published: June 2021

A vast body of research underlies the ascendancy of criminogenic risk assessment, which was developed to predict recidivism. It is unclear, however, whether the empirical evidence supports its expansion across the criminal legal system. This meta-review thus attempts to answer the following questions: 1) How well does criminogenic risk assessment differentiate people who are at high risk of recidivism from those at low risk of recidivism? 2) How well do researchers’ conclusions about (1) match the empirical evidence? 3) Does the empirical evidence support the theory, policy, and practice recommendations that researchers make based on their conclusions? A systematic literature search identified 39 meta-analyses and systematic reviews that met inclusion criteria. Findings from these meta-analyses and systematic reviews are summarized and synthesized, and their interpretations are critically assessed. We find that criminogenic risk assessment’s predictive performance is based on inappropriate statistics, and that conclusions about the evidence are inconsistent and often overstated. Three thematic areas of inferential overreach are identified: contestable inferences from criminalization to criminality, from prediction to explanation, and from prediction to intervention. We conclude by exploring possible reasons for the mismatch between proponents’ conclusions and the evidence, and discuss implications for policy and practice.
Predictability of rotational tooth movement with orthodontic aligners comparing software-based and achieved data: A systematic review and meta-analysis of observational studies
Authors: Koletsi Despina , Iliadi Anna , Eliades Theodore
Published: June 2021

Objective:

To evaluate all available evidence on the prediction of rotational tooth movements with aligners.

Data sources:

Seven databases of published and unpublished literature were searched up to 4 August 2020 for eligible studies.

Data selection:

Studies were deemed eligible if they included evaluation of rotational tooth movement with any type of aligner, through the comparison of software-based and actually achieved data after patient treatment.

Data extraction and data synthesis:

Data extraction was done independently and in duplicate and risk of bias assessment was performed with the use of the QUADAS-2 tool. Random effects meta-analyses with effect sizes and their 95% confidence intervals (CIs) were performed and the quality of the evidence was assessed through GRADE.

Results:

Seven articles were included in the qualitative synthesis, of which three contributed to meta-analyses. Overall results revealed a non-accurate prediction of the outcome for the software-based data, irrespective of the use of attachments or interproximal enamel reduction (IPR). Maxillary canines demonstrated the lowest percentage accuracy for rotational tooth movement (three studies: effect size = 47.9%; 95% CI = 27.2–69.5; P < 0.001), although high levels of heterogeneity were identified (I2: 86.9%; P < 0.001). Contrary, mandibular incisors presented the highest percentage accuracy for predicted rotational movement (two studies: effect size = 70.7%; 95% CI = 58.9–82.5; P < 0.001; I2: 0.0%; P = 0.48). Risk of bias was unclear to low overall, while quality of the evidence ranged from low to moderate.

Conclusion:

Allowing for all identified caveats, prediction of rotational tooth movements with aligner treatment does not appear accurate, especially for canines. Careful selection of patients and malocclusions for aligner treatment decisions remain challenging.
Gas-phase generation of dinuclear Au(I)-Au(II) complexes by laser desorption ionization mass spectrometry
Authors: Kasperkowiak Małgorzata , Durnik Michalina , Jankowski Wojciech , Hoffmann Marcin , Gierczyk Błażej , Frański Rafał
Published: June 2021

Alkali metal chloroaurates(III) were analysed by laser desorption ionization mass spectrometry. Among a number of generated gas-phase ionic clusters, the unusual ions [MAu2Cl5]- (were M stands for Na, K, Rb, Cs) were detected. The spectra of metastable ions and quantum mechanics calculations show the presence of unprecedented Au(I)-Au(II) interactions in the clusters.
Transnational identification processes: An association of young business leaders
Authors: Zølner Mette
Published: June 2021

This article raises the question of how organisational identification emerges at distance and across cultural contexts. The question is explored in an empirical study of identification processes among Moroccan members of an international association that assemble young leaders and entrepreneurs in small- and medium sized companies. On the basis of a narrative analysis of interviews, observations, and documents, the article illustrates two mutually reinforcing identification processes: One is based on face-to-face social interaction with likeminded peers locally; another is imaginary in the sense that the Moroccan members envision members in other countries to be like themselves and what they aspire to become. This contributes to crosscultural management literature in three ways: first, the study adopts a transnational lens that shows the need to go beyond a national perspective and to explore identification at the intersection between the global and local; second, the study draws on concepts of imagined community (Anderson, 1983) and community of sentiments (Appadurai, 1996) to conceptualise the imaginary part of the identification processes, which transcends locality. Third, the study contributes methodologically by showing how the distinction between translocal and local narratives allows to analyse the interplay between an imagined transnational community and a local face-to-face community.
Long-term orientation and the passage of time: Is it time to revisit Hofstede’s cultural dimensions?
Authors: Chun Douglas , Zhang Zhen , Cohen Eric , Florea Liviu , Genc Omer F
Published: June 2021

Hofstede’s cultural dimensions are one of the most commonly referenced cultural models in the literature, but it has also been criticized for its inflexibility in terms of allowing for cultural changes over time. In this study, we focus on one salient dimension of national culture, long-term orientation (LTO), to investigate cultural change over time. Using the LTO scale developed by Bearden et al. ((2006) A measure of long-term orientation: development and validation. Journal of the Academy of Marketing Science 34(3): 456–67), we conducted a survey in Brazil, China, Colombia, India, Portugal, Romania, Spain, and Turkey, and collected 1,452 valid responses. Our study provided new evidence on LTO national ranking and cultural change. We found the countries surveyed no longer appear to be in the same relative positions as when Hofstede first published his results in the 1980s, or his more recent results based on data from the World Value Survey (WVS). Implications for practitioners, academics, and students in the cross-cultural management field are discussed.
Beyond Obstacles: Toward Justice for Victims of Sexual Violence in Hungary. A Literature Review
Authors: Parti Katalin , Robinson Robin A. , Kohlmann David , Virágh Enikö , Varga-Sabján Dóra
Published: June 2021

Alarmed by research that reveals Hungary as having one of the lowest reporting rates in cases of sexual violence in Europe, this article provides an overview of the research that explains why, historically, sexual violence has been and continues to be underreported all over the globe, from law enforcement and criminal justice perspective. Furthermore, we describe the unique circumstances that might influence Hungarian victims of sexual violence to make formal reports. Among other possible factors, we discuss rape myth acceptance, victim blaming, feminist activism, institutional betrayal, and media representations of rape. In an effort to provide insight into Hungarian gender politics, this article raises salient theoretical works on gender ideology and gender policy in contemporary Hungary. This article concludes with a discussion on what implications such research in Hungary may have on a global understanding of sexual violence reporting.
Intracranial Hemorrhage After Endovascular Repair of Thoracoabdominal Aortic Aneurysm
Authors: Pini Rodolfo , Faggioli Gianluca , Fenelli Cecilia , Gallitto Enrico , Mascoli Chiara , Spath Paolo , Gargiulo Mauro
Published: June 2021

Background

Intracranial hemorrhage (ICH) is a rare but devastating complication of thoracoabdominal aortic aneurysm (TAAA) repair with fenestrated/branched endograft (f/bEVAR). The cerebrospinal fluid drainage (CSFD) is considered one of the leading causes; however, other possible concomitant factors have not been individualized yet. The aim of the present work was to evaluate the pattern of ICH events after f/bEVAR for TAAA and to identify possible associated factors.

Materials and Methods

All f/bEVAR procedures for TAAA performed in a single academic center from 2012 to 2020 were evaluated. ICH was assessed by cerebral computed tomography if neurological symptoms arose. Pre-, intra-, and postoperative characteristics were analyzed in order to identify possible factors associated.

Results

A total of 135 f/bEVAR were performed for 72 (53%) type I, II, III and 63 (47%) type IV TAAA; 74 (55%) were staged procedures, 101 (73%) required CSFD, and 24 (18%) were performed urgently. The overall 30-day mortality was 8% (5% in elective cases); spinal-cord ischemia occurred in 11(8%) and ICH in 8 (6%) patients. All ICH occurred in patients with CSFD. ICH occurred intraoperatively in 1 case, inter-stage in 4 and after F/BEVAR completion in 3, after a median of 6 days the completion stage. Three (38%) of 8 patients with ICH died at 30 days and ICH was associated with 30-day mortality: odds ratio (OR) 13.2, 95% confidence interval (CI): 2.3–76, p=0.01. The analysis of the perioperative characteristics identified platelet reduction >60% (OR 11, 95% CI 1.6–77, p=0.03), chronic kidney disease (16% vs 0%, p=0.002), and total volume of liquor drained >50 mL (OR 8.1, 95% CI 1.1–69, p=0.03) as associated with ICH.

Conclusions

Current findings may suggest that ICH is a potential lethal complication of the endovascular treatment for TAAAs and it mainly occurs in patients with CSFD. High-volume liquor drainage, platelet reduction, and chronic kidney disease seems increase significantly the risk of ICH and should be considered during the perioperative period and for further studies.
Foreign Ownership of Production Companies as a New Mechanism of Internationalizating Television: The Case of Australian Scripted Television
Authors: Lotz Amanda D. , Sanson Kevin
Published: June 2021

This article explores the rise in foreign television production company ownership at the beginning of the twenty-first century as a new mechanism of internationalization. It joins mechanisms such as foreign program sales and transnational satellite channels in shifting television further from its domestic origins. To date, examination of television’s internationalization has focused on programs and programming. Foreign ownership may be a less obvious “cultural” form of business internationalization, but it nevertheless affects the television culture made available in many places and poses consequences for cultures of consumption. Foreign ownership also opens up new avenues of inquiry for global television scholars to question the shifting geographies of power in the field of television production.
CARMA3 Transcriptional Regulation of STMN1 by NF-κB Promotes Renal Cell Carcinoma Proliferation and Invasion
Authors: Shi Du , Zhang Zhe , Kong Chuize
Published: June 2021

CARD-containing MAGUK protein 3 (CARMA3) is associated with tumor occurrence and progression. However, the signaling pathways involved in CARMA3 function remain unclear. We aimed to analyze the association between CARMA3 and stathmin (STMN1) through the NF-κB pathway, which is associated with cell proliferation and invasion, in clear cell renal cell carcinoma (ccRCC). We evaluated the effects of CARMA3 and STMN1 expression on cell migration, proliferation, and invasion in various cell lines, and their expression in tissue samples from patients with ccRCC. CARMA3 was highly expressed in ccRCC tissues and cell lines. Moreover, CARMA3 promoted the proliferation and invasion of RCC cells by activating the NF-κB pathway to transcribe STMN1. Stathmin exhibited a consistent profile with CARMA3 in ccRCC tissue, and could be an effector for CARMA3-activated cell proliferation and invasion of ccRCC cells. In summary, CARMA3 may serve as a promising target for ccRCC treatment.
Effect of Salvage Radiotherapy and Endocrine Therapy on Patients with Biochemical Recurrence After Prostate Cancer Operation— a Meta‑Analysis
Authors: Yuan Yong , Zhang Qiang , Xie Chaofan , Wu Tao
Published: June 2021

Context:

Several studies reported the application of androgen deprivation therapy and radiotherapy in patients with biochemical recurrence after prostate cancer operation.

Objective:

To perform a systematic review and meta-analysis evaluating of endocrine therapy and radiotherapy in patients with biochemical recurrence after prostate cancer surgery. The primary end point was biochemical progression-free survival (bPFS). Secondary end point was overall survival (OS).

Methods:

A systematic review of PubMed/Medline, Embase, and Cochrane databases to identify relevant studies published in English up to March 2020. Twelve studies were selected for inclusion.

Results:

There were 11 studies included in the present study. Including two randomized controlled trials and nine cohort studies. The meta-analysis shows a significant bPFS benefit from androgen deprivation therapy and radiotherapy in patients with biochemical recurrence after prostate cancer operation. (hazard ratio [HR]: 0.57; 95% confidence interval CI, 0.52–0.63; p < .001). For patients with GS < 7 and low-risk patients, combined treatment can have a benefit for BPFs (HR: 0.53; 95% CI, 0.37–0.76; HR: 0.58; 95% CI, 0.36–0.93). Androgen deprivation therapy and radiotherapy in patients with biochemical recurrence was associated with a slightly OS improvement (HR: 0.73; 95% CI, 0.57–0.93; p = 0.01).

Conclusions:

Compared with salvage radiotherapy alone, This meta-analysis shows a significant bPFS benefit from endocrine therapy combined with salvage radiotherapy in patients with biochemical recurrence after prostate cancer operation. And benefit more for high-risk groups. However, there was no significant benefit in group GS ≥ 8. It shows a slightly OS benefit from endocrine therapy combined with salvage radiotherapy in patients with biochemical recurrence.
Identifying Signs and Symptoms of Obstructive Sleep Apnea in a Men’s Health Clinic: The Utility of Home Sleep Apnea Testing During COVID-19
Authors: Hart Alexander , Robertus Steffanie , Dyken Mark , Pearlman Amy
Published: June 2021

The objective of the study was to identify symptoms of men presenting for an outpatient urology visit that prompted referral for a Home Sleep Apnea Test (HSAT) to assess for obstructive sleep apnea (OSA) by a single provider. To assess the proportion of patients referred for the HSAT who underwent the test and, out of these patients, the proportion of men diagnosed with sleep apnea, we performed a retrospective chart review of men 18–99 years old seen by a single provider in the Department of Urology referred for an HSAT to evaluate for presenting symptoms. Patients with a prior diagnosis of OSA were excluded. Eighteen patients were identified (mean age at time of referral 51 + SD 13 years). Half of patients reported erectile dysfunction/concerns, 56% reported nocturia, 44% had been diagnosed with testosterone deficiency, and 39% reported low libido. Nearly all (89%) of patients snored, all reported fatigue, 56% were over the age of 50, 44% had a BMI >35, and 78% had hypertension. Twelve patients completed the HSAT, all of whom were diagnosed with OSA for which continuous positive airway pressure (CPAP) therapy was initiated. Men presenting with genitourinary concerns to an outpatient urology clinic may also have OSA. About half of included patients reported genitourinary concerns. Hundred percent of patients who completed their sleep study were diagnosed with OSA. Genitourinary concerns, in addition to signs and symptoms commonly associated with OSA, should prompt consideration of sleep apnea evaluation.
Design and cost estimation of solar powered reverse osmosis desalination system
Authors: Saleem Muhammad Wajid , Abbas Asad , Asim Muhammad , Uddin Ghulam Moeen , Chaudhary Tariq Nawaz , Ullah Asad
Published: June 2021

Photovoltaic assisted reverse osmosis (PV-RO) has been proven an efficient renewable energy-based desalination technique to provide drinkable water, especially in remote areas. In this manuscript, a simulation based RO design system was adopted to evaluate the desalination performance for three cities of Pakistan, that is, Lahore, Hasil Pur, and Faisalabad. The inlet concentration of Lahore, Hasil Pur, and Faisalabad was reduced from 1495, 2190, and 7683 TDS to 295.44, 237.69, and 241.98 TDS respectively, according to the WHO drinking water recommendations. The RO desalination system was integrated with the photovoltaic system to fulfill the energy requirement for desalination. The energy requirement for the RO system for the working of 10 h/day with the freshwater production rate of 0.80 m3/h for Lahore, Hasil Pur, and Faisalabad is 60, 95, and 311 kWh/month, respectively. According to PVsyst software, the energy demand can be accomplished by installing 9 PV panels in Lahore, 15 PV panels in Hasil Pur, and 40 PV panels in Faisalabad. The simulation results in PVsyst showing that the battery losses will be 52.2% in Lahore, 51.1% in Hasil Pur, and 49% in Faisalabad.
Contemplating Law, Film and Mennonites
Authors: Schulz Jennifer L.
Published: June 2021

In this article, I put Carlos Reygadas’ prize-winning art film, Stellet Licht, to use for Law and Film purposes. Stellet Licht (or Silent Light) is the first film made in the medieval German/Prussian dialect, Plautdietsch (or Low German), and filmed in an Old Order (very conservative) Mennonite colony in Mexico. Viewers of Stellet Licht must be prepared to be contemplative because the film often eschews dialogue or action in favour of contemplation. This fictitious film invites us to contemplate a heterosexual love triangle and provides a novel site for thinking about how law and patriarchy can unconsciously work in our lives. When we do the contemplative work invited by the film, we not only see law differently, but we can also imagine miraculous reconciliation between people.
Towards media systems framework in Asia Chinese and Korean media on framing the initial COVID-19 pandemic
Authors: Cho Sookyung , Wang Ziyi
Published: June 2021

Due to the relative lack of media comparison studies within Asian contexts, theoretical frameworks based in Western societies have been applied to knowledge production in the global South. Using a ‘most different’ design, this study compares the dimensions of media systems reflected in two Chinese and two Korean newspapers in their initial coverage of the COVID-19 pandemic. Content analysis showed statistically significant differences in distribution of sources, topics and valence, usage of frame types, and actors including domestic government and foreign entities held responsible between the two groups of media. Based on political implications of crisis on Chinese and Korean news content, we mainly discuss political instrumentalization and parallelism in the media in an Asian context. Finally, we open up the dimensions of media system from an Asian perspective and address the need for future research.
Preoperative perfusion index as a predictor of post-anaesthetic shivering in caesarean section with spinal anaesthesia
Authors: Nasution Mukri P , Fitriati Mariza , Veterini Anna S , Kriswidyatomo Prihatma , Utariani Arie
Published: June 2021

Background

Post-anaesthetic shivering is frequently preceded by a decrease in peripheral blood flow. Perfusion index is a fast non-invasive method to assess peripheral blood flow, thus might be correlated with post-anaesthetic shivering.

Aim

To analyse the relationship between preoperative perfusion index and post-anaesthetic shivering in patients undergoing caesarean section with spinal anaesthesia.

Methods

In this prospective observational study, preoperative perfusion index measurements were performed on 40 participants who were undergoing elective caesarean section under spinal anaesthesia. Spinal anaesthesia was performed using Lidodex (Lignocaine + Dextrose 5%) at vertebrae L4–L5 or L3–L4 interspace. Shivering was observed until 120 minutes according to the Crossley and Mahajan scale. Statistical analysis was performed to examine the correlation and cut-off of preoperative perfusion index as a predictor for post-anaesthetic shivering.

Result

There was a significant relationship between preoperative perfusion index with the incidence ( p = 0.005) and the degree ( p = 0.014) of post-anaesthetic shivering. The preoperative perfusion index cut-off value based on the ROC curve was 4.2 (AUC = 0.762, p = 0.002) with a sensitivity of 73.9% and specificity of 88.2%. Participants with preoperative PI < 4.2 had a greater risk of post-anaesthetic shivering ( p < 0.001, RR = 3.13).

Conclusion

Preoperative perfusion index less than 4.2 can predict post-anaesthetic shivering in patients undergoing caesarean section with spinal anaesthesia.
Current concepts of the perioperative management of closed ankle fractures
Authors: Chen Xiaoyu , Lim Jiang An , Zhou Andrew , Thahir Azeem
Published: June 2021

Ankle fractures are common injuries that can result in substantial morbidity in the population. This review discusses the management of closed ankle fractures and outlines the recent evidence and guidelines on perioperative management. In general, a detailed history should be undertaken, followed by examination and imaging of the affected limb. Fixation is based on the AO principles of fracture management that aims towards restoring stability of the joint and reducing the risk of long-term complications. A multidisciplinary approach towards perioperative management is recommended in view of the increasing proportion of aging patients with significant comorbidities.
Gendering arctic memory: Understanding the legacy of Josephine Diebitsch-Peary
Authors: Reeploeg Silke
Published: June 2021

The study of memory cultures often foregrounds the recovery of denied historical truths, with the recognition that social and cultural norms not only shape canonical versions of the past, but continue to be complicit in legitimised forms of forgetting and erasure. This article investigates the intersections between personal archives and other forms of cultural expression in acts of collective memoralization and forgetting. Using the personal archives of Josephine Diebitsch-Peary, the research introduces the concept of coloniality to studying Arctic memory cultures by examining the role of gender in the context of Arctic exploration. The article concludes that an understanding of the coloniality of knowledge and its connections to epistemic violence is crucial to the study of memory and historical legacy in the Arctic.
Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
Authors: Abeldaño Zuñiga Roberto Ariel , González-Villoria Ruth Ana María , Elizondo María Vanesa , Osorio Anel Yaneli Nicolás , Martínez David Gómez , Coca Silvia Mercedes
Published: June 2021

Aims:

Given the variability of previously reported results, this systematic review aims to determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients diagnosed with COVID-19.

Methods:

We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, and ventilation requirement.

Results:

A total of 51 studies were retrieved from the databases. Five articles were finally included in the data extraction and qualitative and quantitative synthesis of results. The overall risk of bias in the reviewed articles was established at low-risk only in two trials. The meta-analysis suggests that there is no benefit of convalescent plasma compared with standard care or placebo in reducing the overall mortality and the ventilation requirement. However, there could be a benefit for the clinical improvement in patients treated with plasma.

Conclusion:

Current results led to assume that the convalescent plasma transfusion cannot reduce the mortality or ventilation requirement in hospitalized patients diagnosed with SARS-CoV-2 infection. More controlled clinical trials conducted with methodologies that ensure a low risk of bias are still needed. The reviews of this paper are available via the supplemental material section.
Numerical prediction of the ignition probability of a lean spray burner
Authors: Palanti Lorenzo , Andreini Antonio , Facchini Bruno
Published: June 2021

The optimization of the igniter position is a critical issue in modern aviation gas turbines since it can help to minimize the amount of energy required for ignition and to guarantee a fast relight in case of flameout. From a numerical perspective, several spark discharges should be simulated for each spark position, to account for different realizations due to time-dependent turbulent motions. Unfortunately, standard simulations are impractical to use for this purpose, due to the need of carrying out several unsteady simulations, leading to a huge associated computational effort. This is why low-order models have been developed, providing an affordable estimation of the local ignition probability, by sacrificing the accuracy and the physical consistency of the prediction. In the present work, a previously developed low-order design model has been implemented in ANSYS Fluent 2019R1® and used to investigate the ignition performance of a single-sector, confined spray flame, where data from laser ignition experiments are available. A non-reactive Large Eddy Simulation, which is validated against experimental data, provides the base flow needed to feed the model. If the tuning parameters of the ignition model are well calibrated, it provides quite good results. In the test case here investigated, it is shown that ignition is possible in the outer recirculation zone and very unlikely elsewhere. Later, a discussion about the effect of the most relevant tuning parameters is carried out. It is shown that the model mostly succeed to identify the area of possible ignition, even if the lack of calibration could lead to a poorer agreement with the experimental data.
NDUFA4L2 promotes trastuzumab resistance in HER2-positive breast cancer
Authors: Yuan Yuan , Gao Huanyao , Zhuang Yongxian , Wei Lixuan , Yu Jia , Zhang Zhe , Zhang Lili , Wang Liewei
Published: June 2021

Background:

Trastuzumab (Herceptin) is the key systemic therapy for HER2-positive breast cancer. However, the initial response rate is limited to approximately 50% in patients. Moreover, most patients, especially at an advanced stage, eventually develop acquired resistance. Understanding the mechanisms of trastuzumab resistance is crucial for achieving better treatment outcome in this group of patients.

Methods:

A trastuzumab-resistant (TR) cell line was developed using the BT474 HER2-positive breast cancer cell line. Whole-transcriptome expression array was performed and the TR-related gene NDUFA4L2 was identified by differential expression analysis between BT474 and BT474-TR. Mitochondrial localization of NDUFA4L2 was confirmed by immunofluorescence and western blotting using mitochondrial fractionation. Mitochondrial function and energy metabolism were evaluated using Seahorse, ATP production, and lactate production assays, and cellular reactive oxygen species (ROS) levels were determined using DCFDA. NDUFA4L2 expression in patients was evaluated by immunohistochemistry, and relapse-free survival was analyzed using the Kaplan–Meier method.

Results:

NDUFA4L2 was highly expressed in the TR HER2-positive breast cancer cell line. High expression level of NDUFA4L2 was associated with shorter relapse-free intervals in trastuzumab-treated HER2-positive breast cancer patients. Overexpression of NDUFA4L2 enhanced Warburg effects, enhanced aerobic glycolysis, reduced oxygen consumption, and lowered ROS production. Mechanistically, overexpression of NDUFA4L2 facilitated mitochondrial relocalization of HER2 and suppressed ROS production, thus rendering cancer cells more resistant to trastuzumab treatment.

Conclusions:

We identified NDUFA4L2 as a new biomarker and potential therapeutic target for TR HER2-positive breast cancer.
Efficacy and safety of celecoxib combined with JOINS in the treatment of degenerative knee osteoarthritis: study protocol of a randomized controlled trial
Authors: Kim Man Soo , Koh In Jun , Sung Yong Gyu , Park Dong Chul , Yang Sung Cheol , In Yong
Published: June 2021

Background:

The aim of this study will be to investigate the therapeutic effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) along with symptomatic slow-acting drugs for the treatment of osteoarthritis (SYSADOA), JOINS tablets, for degenerative knee osteoarthritis (OA) treatment and to determine the analgesic and anti-inflammatory effects of the combination therapy. In addition, we will investigate whether JOINS treatment alone after NSAID and JOINS combination treatment is effective in relieving and maintaining knee OA symptoms.

Methods:

This study will be a prospective, randomized, double-blind endpoint study design. All patients will be randomly assigned to either intervention (celecoxib+JOINS) or control (celecoxib+placebo) groups. In Part 1, the intervention group will be administered celecoxib once a day and JOINS three times a day for a total of 12 weeks. In the control group, celecoxib will be administered once a day and JOINS placebo three times a day for a total of 12 weeks. In Part 2, JOINS alone and JOINS placebo alone will be administered for an additional 24 weeks in both groups, respectively. The primary endpoint will be the amount of change during the 12 weeks as assessed using the Western Ontario and McMaster Universities Osteoarthritis Index total score compared with baseline. The secondary endpoint will be the amount of change at 1, 4, 12, 24, and 36 weeks from the baseline for pain visual analog scale, Brief Pain Inventory, Short Form Health Survey-36 and biomarkers.

Results:

The trial was registered with Clinical-Trials.gov (NCT04718649). The clinical trial was also registered on Clinical Research Information Service (CRIS) with the trial registration number KCT0005742.

Conclusions:

The combination treatment of the most commonly used SYSADOA drug, JOINS, and selective COX-2 inhibitor celecoxib as the representative NSAID for knee OA treatment, can be compared with celecoxib alone treatment to determine the safety or therapeutic effect.
Association of C-reactive protein and non-steroidal anti-inflammatory drugs with cardiovascular events in patients with psoriatic arthritis: a time-dependent Cox regression analysis
Authors: Lam Steven H. , So Ho , Cheng Isaac T. , Li Edmund K. , Wong Priscilla , Li Tena K. , Lee Alex Pui-Wai , Tam Lai-Shan
Published: June 2021

Aims:

Psoriatic arthritis (PsA) is associated with accelerated atherosclerosis due to underlying inflammation. Whether inflammatory burden and drugs used to suppress inflammation over time are associated with cardiovascular (CV) events remained unclear. This study aims to examine the time-varying effect of C-reactive protein (CRP) levels and the use of drugs, including non-steroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs, on the risk of CV events independent of traditional CV risk factors in PsA patients.

Methods:

A retrospective cohort analysis was performed in patients with PsA who were recruited from 2008 to 2015 and followed until the end of 2019. The outcome was occurrence of a first CV event. Framingham risk score (FRS) was used to quantify the traditional CV risk. Cox proportional hazard models with time-varying CRP levels and drugs used were analysed to identify the risk factors for CV events in PsA patients.

Results:

Two hundred patients with PsA [median age: 47.5 (40.0–56.0); male: 119 (59.5%)] were recruited. After a mean follow-up of 8.8 ± 3.8 years, 30 (15%) patients developed a first CV event. The multivariable Cox regression model showed that time-varying CRP level [hazard ratio (HR) 1.02, 95% confidence interval (CI) 1.00–1.04] and NSAIDs exposure (HR 0.38, 95% CI 0.15–0.96) were significantly associated with CV events after adjusting for baseline FRS (HR 5.06, 95% CI 1.84–13.92).

Conclusion:

Increased inflammatory burden as reflected by elevated CRP level was associated with increased risk of CV events, while the risk was significantly reduced with NSAIDs use in PsA patients.
Vertical position can affect categorization of the rich and the poor in Chinese culture
Authors: Li Qiong , Deng Chen , Zuo Bin , Zhang Xiaobin
Published: June 2021

This study explored whether vertical position affects social categorization of the rich and the poor. Experiment 1 used high- and low-income occupations as stimuli, and found participants categorized high-income occupations faster when they were presented in the top vertical position compared to the bottom vertical position. In Experiment 2, participants responded using either the “up” or “down” key to categorize high- and low-income occupations, and responded faster to high-income occupations with the “up” key and low-income occupations with the “down” key. In Experiment 3, names identified as belonging to either rich or poor individuals were presented at the top or bottom of a screen, and the results were the same as in Experiments 1 and 2. These findings suggest that social categorization based on wealth involved perceptual simulations of vertical position, and that vertical position affects the social categorization of the rich and the poor.
20(S)-Protopanaxadiol Alleviates Myocardial Ischemia/Reperfusion Injury in Rats Through Suppression of Oxidative Stress and Apoptosis
Authors: Jiang Yichuan , Yu Qian , Sui Dayun , Yu Xiaofeng , Xu Huali , Li Min
Published: June 2021

20(S)-protopanaxadiol (PPD) is an active natural product which is transformed from protopanaxadiol-type ginsenosides. The present study was conducted to evaluate the effects of PPD on myocardial ischemia/reperfusion (I/R) injury in a rat model. PPD (20mg/kg) or positive-control drug Diltiazem (10mg/kg) was administered daily for 7 days before left anterior descending I/R operation. After 2-hour reperfusion, changes of cardiac morphology, structure, and function were evaluated by HE staining and echocardiography. Myocardial infarct size was assessed using nitroblue tetrazolium staining. The activities of cardiac enzymes in serum were also evaluated. Cardiomyocyte apoptosis was detected using the terminal dUTP nick end labelling (TUNEL) assay. The extent of oxidative stress was evaluated according to the activities of superoxide dismutase (SOD) and glutathione per oxidase (GPx) and the levels of malondialdehyde (MDA). Western blot and immunohistochemistry were used to determine the expression of apoptosis associated proteins, including Bcl-2, Bax, cleaved Caspase-3, cleaved Caspase-9, and cytochrome C. According to the results, PPD reduced I/R‑induced increases in myocardial infarct size and improved cardiac function. Furthermore, PPD decreased cardiomyocyte apoptosis on TUNEL staining, which was verified by increased Bcl-2, and decreased expression of Bax, cytochrome C, cleaved Caspase-9, and cleaved Caspase-3 in I/R rat myocardium. Additionally, PPD reduced MDA levels and increased the anti-oxidative capacity by upregulating the activities of SOD and GPx. Taken together, the results suggest that PPD serves a protective role against oxidative stress and cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury.
Crisis Communication on Social Media: What Types of COVID-19 Messages Get the Attention?
Authors: Kwok Linchi , Lee Jungwoo , Han Spring H.
Published: June 2021

This study assessed internet users’ attention to hospitality companies’ COVID-19 messages on social media. We used 657 Facebook and 754 Twitter messages initiated by eight of the world’s largest hotel chains between January and mid-June 2020 for the exploratory analysis. Under the situational crisis communication theory, the analysis reveals that hotels shared five types of COVID-19 ( Prevention, Reminding, Ingratiation, Victimage, and Updates) versus Non-COVID-19 messages. Descriptive analysis and a series of t test, analysis of variance, and post hoc analyses reveal that hotels did not share any COVID-19 information until March 2020. Moreover, COVID-19 messages only accounted for about 20% of all messages, among which hotels shared Ingratiation and Updates messages most often. COVID-19 messages received more reactions, comments, and shares/retweets than Non-COVID-19 messages on both Facebook and Twitter, indicating the attention paid to the COVID-19 messages posted on a business’ social media page, which can help businesses spread the information in their networks. Specifically, Prevention, Reminding (although underused), Ingratiation, Updates, and messages with photos and videos received more attention. Such findings extend the crisis communication literature and help businesses develop effective communication strategies to engage their stakeholders on social media during the pandemic.
A Case of Neurosarcoid Presenting as Multiple Intraparenchymal Hemorrhages
Authors: Mehta Amit , Khan Fahad , Wagner Chris , Hashemzadeh Taymour , Stemer Andrew , Sloan Emily A , Mayson Douglas , Amjad Faria
Published: June 2021

This report explores the case of a 49-year-old African American male with a six-month history of multifocal neurological deficits who presented to an outside hospital after a generalized seizure. Patient was transferred to our tertiary medical center after brain imaging showed multiple bilateral supratentorial intraparenchymal hemorrhages (IPH). A brain biopsy confirmed parenchymal and perivascular non-caseating granulomas with vasculitis. The patient was definitively diagnosed with neurosarcoidosis (NS) and his condition improved with high dose corticosteroids and additional immunosuppressive therapies. Intracranial hemorrhage in the setting of NS is extremely rare, with fewer than thirty documented cases; however, this is likely an underestimation of its true prevalence. This case illustrates the difficulty in diagnosis as many other etiologies of IPH must be considered. Additionally, the clinical course and manifestations of NS is often quite variable. The uniqueness of this case lies in the rapid progression from seemingly incidental microhemorrhages to multiple large IPHs over two months. While the cause of this progression is not immediately apparent, a possible cause may be inadequate initial treatment due to delayed diagnosis. Our case demonstrates the importance of early recognition and initiation of immunosuppressive therapy, potentially leading to dramatic clinical improvement, as seen in this patient.