bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Pain in the Development of Alcohol Use Disorders: Ethanol-evoked Dopamine Release Alterations in the Rat Nucleus Accumbens
Authors: Cuitavi Javier , Riera-Calabuig Ana , Campos-Jurado Yolanda , Lorente Jesús , Polache Ana , Hipólito Lucia
Published: June 2024

Purpose
Alcohol use disorders (AUDs) are influenced by factors that can initiate, maintain, or induce relapse. Chronic pain has been linked to AUD as both a risk factor and a consequence of prolonged alcohol exposure. Pain share common neurological pathways with AUDs, and, in fact, alters the functioning of the mesolimbic dopaminergic system suggesting a plausible interaction. This study aims to investigate the effect of inflammatory pain on long-term alcohol intake in rats without prior alcohol consumption and observe changes in mesolimbic dopaminergic transmission.
Methods
Inflammatory pain was induced in eight-week-old Sprague Dawley rats using complete Freund adjuvant (CFA), while controls received saline. Two protocols were followed: one group had continuous access to 20% ethanol for one month (n = 10 per sex), and the second group for three months (n = 8 per sex) in a two-bottle choice paradigm. Mechanical nociception was assessed weekly using the Von Frey test. Dopamine levels in the nucleus accumbens core were measured through microdialysis during the final 1.5 months of ethanol exposure in the second cohort.
Results
After a month of alcohol exposure, rats showed no differences in alcohol consumption. However, from the second month until the end, rats exhibited a non-sex-dependent decrease in alcohol intake, significantly lower in CFA-animals. This reduction was accompanied by a blunted ethanol-evoked dopamine release in the nucleus accumbens.
Conclusion
These findings provide insights into the effect of pain on alcohol-elicited neurochemical responses and drinking behaviour, showing how pain alters dopamine response to alcohol, affecting drinking patterns and prolonging nociception from CFA.
Estimation from Recall-Based Competing Risk Data: A Multilevel Framework
Authors: Panwar M. S. , Tomer Sanjeev K. , Yadav C. P.
Published: June 2024

This study aims to analyze recall-based data on multiple causes of an event, hypothesizing that the likelihood of recall depends on the elapsed time between monitoring and the time-to-event. The recall probability is modeled using this elapsed time. Addressing the challenge posed by non-recalled observations, which yield interval-censored time-to-event data often with missing causes, the equivalent quantity approach with expectation-maximization and Gibbs sampling are employed. This method handles censored time-to-event data while simultaneously addressing missing causes. Weibull distributions for time-to-event under different causes are considered. In the frequentist approach, parameter estimates are obtained via the expectation-maximization method, with asymptotic confidence intervals calculated using the Fisher information matrix. In the Bayesian setting, a data augmentation algorithm approach is proposed for handling missingness, and nested Gibbs sampling is employed to extract posterior samples. The validation of our methods is conducted through numerical simulations and the analysis of a women's health survey dataset to estimate the age at menopause.
Exploring the mechanisms of Tetrahydrocurcumin in Ameliorating Nonalcoholic Steatohepatitis based on Network Pharmacology and Gut Microbiota Analysis in vivo
Authors: Chen Keyu , Wang Jianbo , Luo Shuang , Quan Yunyun , Fu Jiali , Ma Jiali , Yang Yuying , Liu Yunten , Gao Zhichong
Published: June 2024

Background
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing every year, and there are very few approved therapeutic agents globally, making the search for potentially targeted therapeutic agents important.
Aims
To investigate the anti-NASH effect of tetrahydrocurcumin (THC) and to further study the biological mechanism of tetrahydrocurcumin anti-NASH from the perspective of intestinal flora.
Methods
Seven-week-old male and female C57BL/6J mice were randomly divided into six groups: (1) Control group, (2) Model group, (3) Positive control group, (4) THC low-dose group, (5) THC medium-dose group, and (6) THC high-dose group, and the remaining groups except the control group were fed with high-fat chow for 16 weeks. Serum and liver tissues were collected to study the anti-NASH mechanism of THC using network pharmacology, molecular docking, high-throughput sequencing, and RT-qPCR.
Results
The intervention of THC improved the pathology of NASH, ameliorated liver injury, lowered lipid levels, and inhibited hepatic oxidative stress, inflammatory response and apoptosis compared with the high-fat feed-induced model group. In network pharmacology and animal experimental validation we found that THC reduced the expression of m RNA of PPARG, which may be the key to the improvement of NASH by THC. Intestinal flora analysis showed that THC altered the composition of the intestinal flora, which was characterized by a decrease in the proportion of Firmicutes/Bacteroidota.
Conclusion
The results of this study suggest that THC exerts anti-NASH effects by improving lipid levels, decreasing oxidative stress, attenuating inflammatory responses, and increasing the anti-apoptotic capacity of liver cells, and its efficacy is importantly associated with decreasing the expression of PPARG and improving the intestinal flora. THC is expected to be a potential therapeutic agent for NASH.
Relationships between personality factors and DC/TMD Axis II scores of psychosocial impairment among patients with pain related Temporomandibular Joint Disorders
Authors: Assiri KHALIL IBRAHIM
Published: June 2024

This cross-sectional analytical study aimed to assess the relationship between personality factors and the DC/TMD Axis II scores of psychosocial impairment among patients with pain related temporomandibular joint disorders (TMD). 120 participants (60 females and 60 males) who were diagnosed with pain related TMD according to the Axis I DC/TMD protocol were recruited. The participants were requested to complete four tests including the NEO Five Factor Inventory (NEO-FFI) to assess personality factors and three Axis II DC/TMD tools; the Graded Chronic Pain Scale (GCPS) Version 2.0 to assess TMD pain intensity and pain-related disability, Patient Health Questionnaire-4 (PHQ-4) to assess psychological distress due to TMD pain, and Generalized Anxiety Disorder-7 (GAD-7) to assess patients’ stress reactivity. Results showed that 49.2% of the participants experienced high intensity of characteristic pain, 14.2% reported pain related disability more than 30 days (grade 3 disability days) and had disability scores of 70 or above (grade 3 disability scores), 16.7% demonstrated severe distress, and 18.3% reported severe anxiety due to TMD pain. Females scored higher on all these variables than males (P < .05). Multiple regression analyses indicated that higher extraversion scores, higher agreeableness scores and being a female were associated with higher intensity of characteristic pain (p < .05). Also, higher neuroticism and agreeableness scores were associated with more disability days (p < .05). In addition, higher agreeableness scores were associated with higher disability scores and disability point values (p < .05). Furthermore, lower neuroticism scores and being a female were associated with higher PHQ total scores, while being a female and having a lower level of education were associated with higher GAD total scores (p < .05). In conclusion, personality profiles and gender significantly impact the DC/TMD Axis II scores of psychosocial impairment among patients with pain related TMD.
The Dm element located in the Igκ locus is hypermethylated in primary RAG- deficient pre-B cells
Authors: Wu Caijun , Dong Yanying , Wang Yingjun , Ji Yanhong
Published: June 2024

The Igκ locus undergoes a series of epigenetic changes, such as active histone modifications and DNA demethylation, to participate in V(D)J recombination, which is initiated by RAG endonuclease (also known as RAG1/RAG2), during B cell development in the bone marrow. We previously showed that RAG2 is involved in Igκ locus demethylation in RAG-deficient pre-B cells. The Dm element is located in the Igκ locus and has the highest density of CpG sites. Here, we performed a bisulfite DNA-modification assay and chromatin immunoprecipitation (ChIP) experiment to analyze the epigenetics of the Dm element. We found that the Dm element was hypermethylated in RAG deficiency pre-B cells. However, the Dm element was demethylated in splenic B cells. Moreover, the Dm element exhibited high levels of active histone modifications, such as H3K27Ac and H3K9Ac, and binding of Pax5 to it was detected in B cells. In conclusion, our findings indicate that the methylation status of the Dm element undergoes changes in splenic mature B cells. These results provide new insights into the mechanisms of Igκ locus methylation regulation during B cell development.
Resilience improvement using fault detection method in Multi-Carrier Microgrids
Authors: Ebrahimi Reza , Moradi Mohammad Hasan , Jahangiri Alireza , Abedini Mohammad
Published: June 2024

Power quality has become a vital factor because of the simultaneous use of electric and gas energies in a network (multi-carrier grid) as well as the use of modern electrical equipment. Poor electricity quality is defined as the presence of changes, distortions, or disturbances in voltage, current, and frequency quantities that cause the failure or improper operation of the subscribers' equipment. This research, aims to improve the voltage drop and increase the resilience of the multi-carrier distribution network (Energy Hub) in the event of a short-circuit fault, resulting in the provision of 10% of the total load and an improvement in subscriber welfare. To improve the voltage drop, The first step needs fast fault detection, which is accomplished by using an FCL filter, which is capable of detecting any short-circuit fault in the shortest amount of time by combining the method of estimating frequency fluctuations and the Prony method. After detecting the fault, a combination of DVR and D-STATCOM (DDS) is used to compensate for the voltage drop. The amount of increase in subscriber resilience and welfare will then be investigated. The simulation results show proper performance in identifying the short-circuit fault to prevent the subscribers' collapse and blackout.
Proton Nanomodulators for Enhanced Mn 2+ -mediated Chemodynamic Therapy of Tumors via HCO 3 − Regulation
Authors: Yang Peng , Liu Shaojie , Chen Zhuang , Liu Weijing , Yang Zuo , Yan Haohao , Rao Zhiping , Zhang Xianghan , Zhang Ruili , Wang Zhongliang
Published: June 2024

Background
Mn2+-mediated chemodynamic therapy (CDT) has been emerged as a promising cancer therapeutic modality that relies heavily on HCO3− level in the system. Although the physiological buffers (H2CO3/HCO3−) provide certain amounts of HCO3−, the acidity of the tumor microenvironment (TME) would seriously affect the HCO3− ionic equilibrium (H2CO3 ⇌ H+ + HCO3−). As a result, HCO3− level in the tumor region is actually insufficient to support effective Mn2+-mediated CDT.
Results
In this study, a robust nanomodulator MnFe2O4@ZIF-8 (PrSMZ) with the capability of in situ self-regulation HCO3− is presented to enhance therapeutic efficacy of Mn2+-mediated CDT. Under an acidic tumor microenvironment, PrSMZ could act as a proton sponge to shift the HCO3− ionic equilibrium to the positive direction, significantly boosting the generation of the HCO3−. Most importantly, such HCO3− supply capacity of PrSMZ could be finely modulated by its ZIF-8 shell thickness, resulting in a 1000-fold increase in reactive oxygen species (ROS) generation. Enhanced ROS-dependent CDT efficacy is further amplified by a glutathione (GSH)-depletion ability and the photothermal effect inherited from the inner core MnFe2O4 of PrSMZ to exert the remarkable antitumor effect on mouse models.
Conclusions
This work addresses the challenge of insufficient HCO3− in the TME for Mn2+-mediated Fenton catalysts and could provide a promising strategy for designing high-performance Mn2+-mediated CDT agents to treat cancer effectively.
Text-to-image synthesis based on conditional augmentation DCGAN network
Authors: Li Yunhong , Liang Chengming , Li Limin , Zhu Yaolin , Su Xueping , Zhang Fuxing
Published: June 2024

In this paper, Aiming at the problems of missing image structure and unreal image generated under the condition of text in the Deep Convolutional Generative Adversarial Network (DCGAN) model, In the proposed conditional augmentation DCGAN (CA-DCGAN) model, the initial step entails utilizing a deep convolution network in conjunction with a cyclic text encoder to encode the input text. This encoding process facilitates the extraction of a feature vector representation of the text, which serves as a fundamental aspect of the model’s architecture. Secondly, a conditional augmentation model (CA) is introduced after the representation of text feature vector by an additional conditional variable is generated through the mean and covariance matrix of text feature vector to replace the original text features with a new vector, combine the conditional variable and random noise for the generator’s input, and add KL loss to its training to prevent overfitting, so that the model can converge better. The experimental results show that the image quality generated by the proposed method on oxford-102-flowers and cub-200 data sets is better than that of align GAN, GAN-CLS and GAN-INT-CLS models, and is closer to the real samples. The Inception Score value is increased by 12% and 9.4% respectively, and the FID value is reduced by 9.6% and 8.7% respectively, which validates the effectiveness of the method proposed in this paper.
Causal relationship between serum metabolites and risk of thyroid cancer: a mendelian randomization study
Authors: Wu Guangzhi , Zhang Shuangyuan , Han Xinru , Zhang Hengheng , Zhao Bowen , Du Yang , Han Kaichen , Mei Shijuan
Published: June 2024

Background
The high incidence of thyroid cancer (TC) has become a significant global medical burden. Our research aims to investigate the relationship between serum metabolites and the onset of TC.
Materials and methods
We used two-sample Mendelian randomization (MR) analysis to evaluate the causal relationship between 1,400 serum metabolites and TC. The causal effects were mainly assessed using the inverse variance weighted (IVW) method, wald ratio, and 95% confidence intervals (CI). Sensitivity analyses were performed using Cochran’s Q Test and MR-PRESSO. The MR-Steiger test was applied to examine reverse causal relationships. Additionally, pathway enrichment analysis was conducted for the causal relationships between known metabolites and TC risk.
Results
Out of 1400 metabolites, 20 were associated with TC. These included ratios of 5 metabolites and 15 individual metabolites (13 known, 2 unknown). Among the 13 known metabolites, 5 were identified as protective factors against TC: 1-palmitoyl-2-oleoyl-GPI (16:0/18:2), 1-palmitoyl-2-oleoyl-GPI (16:0/18:1), aspartic acid, 1-stearoyl-2-oleoyl-GPI (18:0/18:1), and 1-stearoyl-2-oleoyl-GPI (18:0/18:2). The remaining 8 metabolites (phosphocholine, 5-methyluridine (ribosylthymine), (R)-3-hydroxybutyrylcarnitine, dimethyl sulfoxide, isobutyrylcarnitine (C5), glycerol 3-phosphate, lactosyl-n-palmitoylsphingosine (d18:1/16:0), and pregnenolone sulfate (C21H34O5S)) were identified as potential risk factors for an increased likelihood of TC occurrence. Among the protective metabolites, the protective effect of 1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) was most significant (P = 0.0036, Odds ratio (OR) = 0.82, 95% CI [0.72–0.94]). Among the risk factors, phosphocholine was the most significant (P = 0.004, OR = 1.39, 95% CI [1.11–1.74]).
Conclusions
This study revealed the potential relationship between serum metabolites and TC.
Chlorogenic acid alleviates the intestinal barrier dysfunction and intestinal flora disorder induced by cisplatin
Authors: Ruiqi Tian , Yinchuan Ding , Shijie Zhang , li Min , Yiran Wang , Qi Wu , Ding Huanhuan , Jinhu Shen , Ce Shi , Min Xue
Published: June 2024

This article conducted research and analysis on the relationship between cisplatin induced intestinal barrier disruption, gut microbiota imbalance, and the protect effect of chlorogenic acid (CGA) on gastro intestine. This article selected C57BL/6J mice as the research object, with an age of 4 weeks and a total of 28 mice. The mice were divided into 4 groups, including the control group (CN), a cisplatin (Cis) group, a CGA treatment group receiving intraperitoneal injections alongside cisplatin (Cis + CGA1), and the last group pre-treated with CGA before cisplatin administration (Cis + CGA2). This study used RT qPCR to determine IL-6, IL-1β and TNF-ɑ mRNA, while serum levels of these cytokines and fecal LPS were determined through ELISA. Western blot was used to analyze the expression of Occludin and ZO-1 proteins in colon tissue, and H&E staining to study the histopathological conditions of the colon tissue. Moreover, this article also utilized high-throughput sequencing to analyze the gut microbiota of feces. The results indicated that CGA administration reduced IL-6, IL-1β and TNF-α level in both colon tissue and serum compared to the Cis group. CGA pretreatment notably enhanced the expression of Occludin and ZO-1 proteins in colon tissues, improved intestinal barrier integrity. Histopathological analysis confirmed the reduction in intestinal inflammation injury with CGA treatment. Moreover, 16S rDNA sequencing showed that while Bacteroidetes and Firmicutes predominated in the control group, the Cis group saw a rise in Proteobacteria, with a notable shift in the gut microbiota's composition and a decrease in α diversity. CGA treatment was able to mitigate these changes induced by cisplatin. All results suggest CGA effectively mitigates the inflammatory response and destruction of the mucosal barrier in the intestines caused by cisplatin, offering a protective effect against the disturbances of intestinal flora.
High-order Michaelis-Menten equations allow inference of hidden kinetic parameters in enzyme catalysis
Authors: Reuveni Shlomi , Singh Divya , Robin Tal , Urbakh Michael
Published: June 2024

Single-molecule measurements provide a platform for investigating the dynamical properties of enzymatic reactions. To this end, the single-molecule Michaelis-Menten equation was instrumental as it asserts that the first moment of the enzymatic turnover time depends linearly on the reciprocal of the substrate concentration. This, in turn, provides robust and convenient means to determine the maximal turnover rate and the Michaelis-Menten constant. Yet, the information provided by these parameters is incomplete and does not allow full characterization of enzyme kinetics at the single molecule level. Here we show that the missing kinetic information can be accessed via a set of high-order Michaelis-Menten equations that we derive. These equations capture universal linear relations between the reciprocal of the substrate concentration and distinguished combinations of turnover time moments, essentially generalizing the Michaelis-Menten equation to moments of any order. We demonstrate how key observables such as the lifetime of the enzyme-substrate complex, the rate of substrate-enzyme binding, and the probability of successful product formation, can all be inferred using these high-order Michaelis-Menten equations.
Changes in lipid, liver, and renal test profiles among patients with severe COVID-19 during and after hospital admission at Saint Peter Specialized Hospital, Addis Ababa, Ethiopia
Authors: Wolde Gedamnesh , Woldesemayat Belete , Biranu Endalkchew , Habtu Wossene , Edao Abebe , Kinde Samuel
Published: June 2024

Objective: The progression of COVID-19 affects multiple organs, abnormal lipid, liver, and renal function tests have beenreported. Hence, this study aimed to determine differences in organ function and lipid profile among patients with severe COVID-19 during and after hospital admission.
Methods: A follow-up study was conducted among COVID-19-admitted patients at St. Peter Specialized Hospital from January 1, 2021, to April 30, 2021. A total of 162 patients were included in the study. Five millilitersof venous blood was collected during admission and on the verge of discharge. Lipid, renal and liver function tests were performedusing aCobas 311 analyser. The data were entered and analysed with SPSS version 25.
Results: The mean differences in total cholesterol, HDL, and LDL at admission and discharge were 20.13 (95% CI; 13.41-26.84; P<0.001), 7.53 (95% CI; 5.24-9.81; P <0.001), and 0.10 (95% CI; 0.06-0.14; P<0.001), respectively. Albumin concentrationincreased significantly at discharge, while the ALT concentration decreasedsignificantly at discharge (P<0.05).
Conclusion: Dyslipidemia and low levels of Albumin were recorded during the progression of COVID-19 (at admission). This indicated severe COVID-19 disease leads to lipid alteration and Additional studies need to better define the disease's association with liver and renal function tests.
Future climate impacts on biodiversity trends in major global rivers
Authors: Wu Yanfeng , Ma Qiusheng , Qin Lei , Penuelas Josep , Liu Xuemei , Wang Guodong , Rousseau Alain. N. , He Fengzhi
Published: June 2024

Climate change has substantially impacted global runoff patterns and biodiversity, yet the response of river biodiversity to future runoff changes remains unclear. Here, we project and characterize this evolution by calculating the Shannon index (SI), a measure of river biodiversity, for 32 major rivers worldwide under future climate scenarios. We find that historically, SI has generally decreased for most rivers (88%), but future projections suggest an overall increase, albeit with values generally lower than those observed historically. Under different Shared Socioeconomic Pathways (SSPs) - SSP1-2.6, SSP3-7.0, and SSP5-8.5 - SI is expected to decrease by 53%, 66%, and 66%, respectively, reflecting altered runoff patterns. The most substantial decrease is projected under SSP3-7.0. Predictions indicate that biodiversity in the majority of rivers will decline notably in the second and third quarters of the 21st century, with some potential for recovery in the final quarter. These findings highlight an escalating threat to river biodiversity globally, posing significant challenges to ecosystem health and integrity.
Prevalence of psychological disorders among patients with multiple sclerosis
Authors: Najati Ghena , Almazroua Salem , Saad Hasan , Alsahhar Muhammad hussam , Almalla Monaf
Published: June 2024

Aim: The aim of this study was to evaluate the frequency of psychiatric disorders, especially mood and anxiety disorders, in a multiple sclerosis center sample of patients with multiple sclerosis in Syria, and its association with sociodemographic and clinical data.
Methods and Materials: A cross-sectional study, patients were evaluated consecutively, for clinical assessment, a structured interview (MINI) was used for the prevalence of psychiatric disorders, and the severity of depression and anxiety symptoms of the Beck Inventory scale was used.
Results: The lifetime prevalence of major depression was 40% in this population, as well as the risk of suicide, and there was no clear association between depression, degree of disability, duration of illness, or interferon beta use.
Conclusion: The prevalence of mood disorders is high in MS. depression is an important factor related to suicide risk and should be systematically examined.
Extensa Infecção Odontogênica: Relato de Caso
Authors: Souza Grassiele dos Santos Magalhães , Pelissaro Gustavo Silva , Paiva-Oliveira Janayna Gomes , Aguillera Maisa de Oliveira , Figueiredo Francielly Thomas , Leite da Silva Julio Cesar , Gaetti Jardim Ellen Cristina
Published: June 2024

As infecções odontogênicas complexas podem disseminar pelos espaços faciais comprometendo estruturas da face e vias aéreas comprometendo a saúde e necessita de intervenção e tratamento imediato. Sendo assim, o objetivo deste trabalho é apresentar um caso clínico de paciente com severa infecção de origem odontogênica disseminada pela hemiface direita. Paciente do sexo masculino, 56 anos, admitido pelo serviço de Cirurgia e Traumatologia Bucomaxilofacial do Hospital Universitário Maria Rosa Pedrossian (Humap-UFMS), Campo grande, MS. Clinicamente apresentou edema na hemiface direita, abertura bucal limitada, presença de fístulas, eritema na região do pilar amigdaliano, assoalho bucal endurecido à palpação e o dente 16 com extensa fratura. Radiograficamente apresentava imagem radiolúcida no periodonto associada à região de molares do lado direito. Os exames laboratoriais evidenciaram leucocitose, anemia e PCR elevado. Diante dos dados clínicos, imaginológicos e bioquímicos foi iniciado antibioticoterapia seguido procedimento cirúrgico, sob anestesia geral, para drenagem, remoção do elemento dental e colocação de drenos. Após melhora do quadro clínico e laboratorial, o paciente recebeu alta.
Approaches for the companies’ promotion in the modern business environment
Authors: Kovalev Valentin , Neiman Ievgen , Dubovenko Maksym , Kaylyuk Oleksandr
Published: June 2024

In today's competitive market, promoting goods and services online is crucial to most companies' business strategies. Therefore, it's essential to understand and systematise digital marketing tools' principles, advantages, and disadvantages to optimize marketing strategies effectively. These tools allow businesses to adapt to market changes quickly, ensuring efficient use of the advertising budget and high returns on investment. Additionally, Internet marketing enables the creation of personalised approaches to customer interaction, boosting their loyalty and satisfaction. Internet marketing, or digital or online marketing, includes all activities promoting goods and services via the Internet. It involves using various online channels and platforms to interact with the target audience to increase brand awareness, sales, and customer loyalty. This article examines the unique aspects of using digital marketing tools and how to optimise their application. By analysing the theoretical and practical principles of modern digital marketing tools, the study categorises the benefits and drawbacks of various digital marketing techniques. The paper analysed the dynamic growth of Internet users worldwide and in Ukraine. The growth in Internet users is driving the development of digital marketing in Ukraine. Brands are actively implementing modern marketing technologies, such as SEO, SMM, content marketing, contextual advertising and email marketing, to reach their audience. The primary tools examined include Search engine optimisation (SEO), Content marketing, Social media marketing (SMM), Contextual advertising (PPC), Email marketing, Video marketing, Mobile marketing, and Influencer marketing. The authors stress the importance of using artificial intelligence to personalise marketing campaigns' target audiences. Automation allows companies to plan and execute marketing campaigns in advance, ensuring efficient management of time and resources, particularly for large companies with extensive marketing networks. The authors concluded that modern marketing technologies based on artificial intelligence and automation are the key to successful online brand promotion, ensuring the competitiveness and efficiency of businesses in the face of constant change.
Clover (Trifolium spp.) Inclusion in Kentucky Bluegrass (Poa pratensis) Lawns
Authors: Boyle Paige E. , Kopp Kelly , Dai Xin , Bushman Bradley , Johnson Paul , Grossl Paul
Published: June 2024

Historically, white clover (Trifolium repens) seed was included in turfgrass seed mixtures to provide biodiversity and nitrogen (N) to lawns. White clover dicultures have been studied recently for inclusion in both warm- and cool-season turfgrasses, with the goals of reducing fertilizer applications and providing pollinator forage in lawns; however, other clovers have not been as widely researched in turfgrass. The objectives of this study were to evaluate 1) if white, strawberry (T. fragiferum), crimson (T. incarnatum), and rose (T. hirtum) clovers can persist in dicultures with Kentucky bluegrass (Poa pratensis); 2) if clover inclusion in dicultures impacts broadleaf weed cover; and 3) if low levels of N fertilization impact clover persistence or quality of clover–bluegrass dicultures. Kentucky bluegrass was grown as a monoculture or as a diculture with each of the four clover species. Each mono- or diculture was then treated with a low rate of N fertilizer (48.8 kg⋅ha–1 N) or no N fertilizer to determine quality and percentage of grass, clover, or weed and bare-soil cover. Dicultures contained similar or less weed and bare-soil cover, and maintained similar or greater quality compared with bluegrass monocultures, indicating clover and Kentucky bluegrass dicultures are suitable alternatives to Kentucky bluegrass monoculture lawns, and can potentially lead to reduced fertilizer and pesticide requirements. Fertilizer generally had no effect on cover, likely because of the low rates of N applied.
Quantitative Trait Mapping for Zebra-stem in Tomato Confirms a Genetic Cause Involving the Interaction of Unlinked Loci
Authors: Subode Su , Cho Jihuen , Francis David M.
Published: June 2024

Zebra-stem of tomato is a disorder characterized by leaf necrosis, wilting, and a stripped pattern on stems of mature plants. Wilting, necrosis, and death of seedlings are also observed. The physiological and genetic causes of zebra-stem are poorly characterized. Anecdotal evidence has suggested pedigrees with S. pimpinellifolium and bacterial speck resistance in the genetic background are often prone to this disorder. We demonstrate a genetic cause using composite interval mapping and association analysis approaches to define quantitative trait loci (QTLs) that contribute to the disorder. A biparental population of F4 partially inbred families was developed for the initial analysis, and four subsequent backcross or F2 populations were used for subsequent validation. Significant QTLs on chromosomes 5 and 10 were identified, explaining ∼60% and 40% of the variation, respectively. Polymorphisms in the Pto locus are strongly associated with the QTL on chromosome 5. The two loci were derived from different parentage, and a significant interaction effect was demonstrated, resulting in the characteristic zebra-stem symptoms when combined.
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Published: June 2024

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Evaluation of specific competencies of university students in hospitality and gastronomy programs
Authors: Zegarra-Alva Monica , Castañeda-Gil Yamilet , Cordova-Buiza Franklin
Published: June 2024

Continuous improvement of professional training was included in the monitoring of the progress of competencies by teachers, considering the importance of fulfilling students’ graduation profile at the end of their professional training. This study aims to evaluate students’ specific competencies in the Hospitality and Gastronomy programs at a private university located on the northern coast of Peru. The methodology is quantitative, applied to a population of 408 students during semesters 2020-1, 2020-2, and 2021-1; through the application of documentary review guides, the students’ competencies were evaluated, as well as the verification of the students’ satisfaction and recommendation regarding the teachers who evaluated such competencies. The results show that Hospitality students achieved 91% compliance with the graduation profile of the specific competencies and, in the case of Gastronomy – 81.25%. On the other hand, in 2020-1, Hospitality had a higher degree of satisfaction based on the teaching of the teachers who evaluated the competencies but a lower degree of recommendation, while Gastronomy evidenced a lower degree of satisfaction and a higher degree of recommendation. Likewise, in 2020-2, Gastronomy evidenced a higher degree of satisfaction and recommendation than Hospitality, and on the contrary, in 2021-1, Hospitality evidenced a higher degree of satisfaction and recommendation than that identified in Gastronomy. It is concluded that Hospitality students stand out with respect to the fulfillment of the graduation profile in semesters 2020-1 and 2021-1, and although there was a closeness in both programs in semester 2020-2, Hospitality always showed better results than Gastronomy.
RUH SAĞLIĞI PROFESYONELLERİNİN YAŞLILARLA PSİKOLOJİK DANIŞMA YAPMAYA DAİR GÖRÜŞLERİNİN İNCELENMESİ
Authors: Akyol Muhammed Emir , Kumcağız Hatice , Gelen İsmail
Published: June 2024

Sağlık koşullarındaki gelişmeler ile birlikte yaşlı bireylerin yaşam kaliteleri artmakta
ve nüfus içerisinde yaşlı bireylerde oransal açıdan artış görülmektedir. Nüfustaki yaşlı
oranının artışı ruh sağlığı hizmetleri üzerinde doğrudan etkiye sahiptir. Şu an ki durumda
ruh sağlığı profesyonellerinin tercihe bağlı olarak yaşlı gruba ruh sağlığı hizmeti verilirken
ilerleyen yıllarda bu durumun bir gereklilik olacağı düşünülmektedir. Bu nedenle bu çalışmada
yaşlılarla psikolojik danışma / terapi süreçlerini yürüten uzmanların görüşlerini incelemek
amaçlanmıştır. Bu amaçla araştırmada psikiyatrist, psikolog ve psikolojik danışmanlardan
oluşan 19 ruh sağlığı profesyonelinin yaşlılarla psikolojik danışma yapmaya dair görüşleri
incelenmiştir. Araştırma nitel araştırma yöntemlerinden bir tipik durum çalışmasıdır.
Gerçekleştirilen kodlama ile açığa çıkan bulgular 5 tema altında sıralanmıştır. Bu temalar
’’Tercihler’’ , ‘’Yaşlılık döneminde psikolojik destek alma: Terapinin yaşı yoktur’’, ‘’Yeterlilik’’,
‘’Zorluklar: Terapi 65 – 70 yaşındaki bir amcaya golf oynatmak gibi midir?’’ ve ‘’Ekonomik
sorunlar, etiketlenme kaygısı ve bilgelik yanılgısı kıskacında terapiye katılım engelleri’’
şeklindedir. Tüm temalar ayrı ayrı yorumlanarak ele alınmış ve uygulamaya dönük somut
önerilerde bulunulmuştur.
Sazyolu Üslubunda "Yaprak Motifi"
Authors: Meço Menekşe , Bilen Yusuf
Published: June 2024

16. yüzyıl Osmanlı Dönemi tezhip sanatının en ihtişamlı yüzyılı olmuştur. Sarayın sanata ve sanatçıya vermiş olduğu değerle birlikte Şah Kulu’nun sernakkaşlığı öncülüğünde ortaya çıkan bu yeni üslûbun en hâkim motifi yapraklardır. Tezhip sanatının en temel motifleri arasında yer alan yapraklar, saz yolu üslûbunda da farklı kompozisyon düzenlemeleri ile göze çarpmaktadır. Bu çalışma saz yolu üslûbunda kullanılan yaprak motiflerini ve eserlerde kullanılan örneklerinin incelenmesi amaçlanmaktadır. Bu kapsamda Topkapı Sarayı Müzesi Kütüphanesi’nde bulunan envanter no. H.2168, y. 15a, envanter no. H.2147, y.20a ve envanter no. H.2135, y.14a’da yer alan saz yolu örnekleri ele alınmaktadır. Saz yolu üslûbunda yapılmış üç eserde kullanılmış olan yaprakların kompozisyon düzenlemeleri biçimsel olarak incelenerek dönemin sanat ve zevk anlayışı ele alınmaktadır. Bu eserler saz yolu yapraklarının şematik yapılarını muhteşem detay ve inceliklerini gözler önüne sermektedir. Şah Kulu’nun saz yolu üslûbunda yaprak motiflerini farklı şekilde kullanması kendinden sonra gelen birçok sanatkâra da ilham kaynağı teşkil etmektedir.
Numerical simulation of supercritical flow in sudden contractions flumes
Authors: Süme Veli
Published: June 2024

In this research, the effect of sudden non-continuous contraction on the energy dissipation of supercritical flows was numerically investigated. This study focuses on energy dissipation in sudden contractions in supercritical flows. The numerical models were studied using FLOW-3D software and the random number generator (RNG) turbulence model. The laboratory tests were performed on sudden contractions of 10–15 cm and used shapes such as geometric trapezoidal and semicircular. Numerical simulations were carried out at a distance of 1.5 m from the supercritical flow generator gate, at a fixed opening of 2.6 cm, with the Froude number in the range of 2.5–7 and the relative contraction in the range of 8.9–9.73. This laboratory study found that as the Froude number of the upstream flow increases, the energy dissipation increases in the upstream (ΔE/E0) and downstream (ΔE/E1). For the 15 cm contraction, the results indicated that the energy loss compared with section A is 48.25% and compared with section B, it is 69.5% more than a free hydraulic jump in this channel. According to the conclusion, this value in trapezoidal constriction is 45.73 and 63.6% higher than in free hydraulic jump, respectively.
The impact of environmental regulation on water resources carrying capacity in the Yangtze River Economic Belt
Authors: Yi Ying , Li Zhenqiang
Published: June 2024

Enhancing environmental regulation (ER) is a key strategy for improving the carrying capacity of water resources. This study employs panel data from 11 provinces and cities within the Yangtze River Economic Belt, spanning from 2008 to 2022, to calculate the carrying capacity of water resources using an enhanced TOPSIS model. It further examines the threshold effect and spatial spillover effect of ER on water resources carrying capacity (WRCC) through the construction of panel threshold models and spatial econometric models, respectively. Findings indicate a stable growth trend in the carrying capacity of water resources across the Yangtze River Economic Belt, with the upstream region typically exhibiting a higher capacity than both the midstream and downstream regions. ER positively impacts WRCC, demonstrating a single threshold effect. Nonetheless, the positive effect of ER on WRCC experiences diminishing marginal returns as industrial structure upgrades. While strengthening ER positively influences the carrying capacity of water resources in local areas, it exerts a negative spatial spillover effect on neighboring regions. In light of these findings, implementing differentiated ER, optimizing industrial structure and collaborative policies and promoting technological innovation are vital for fostering WRCC.
Domicile anglosajón y reenvío: interacción en materia de sucesiones internacionales
Authors: Maseda Rodríguez Javier
Published: June 2024

Se ocupa este trabajo de analizar brevemente los conceptos de domicile of origin, domicile of choice o domicile of dependency, propios de los ordenamientos anglosajones, perfilando las líneas básicas de su complejo régimen jurídico a través del examen de la práctica de common law. Todo ello, en tanto que elemento determinante del funcionamiento del reenvío a la hora de seleccionar el ordenamiento jurídico finalmente aplicable a la sucesión: desde la óptica del Reglamento (UE) 650/2012 (artículo 34 R. 650) y la propia del Derecho doméstico español (artículos 9.8 y 12.2 Código Civil español), tras reciente práctica del Tribunal Supremo español revitalizando la importancia del domicile frente a una práctica anterior más formalista y menos respetuosa con este concepto.
INTEGRAÇÃO ENERGÉTICA SUPLEMENTAR COM ONDAS SONORAS
Authors: Rebello Antônio Cabral
Published: June 2024

Este artigo visa consolidar informações pertinentes às possibilidades de geração de energia com ondas sonoras, partindo de materiais derivados de pesquisas para futura dissertação acadêmica de mesma autoria. A combinação desses dados sob uma ótica especulativa do design permite-nos condições de elaborar princípios conceituais de produtos e serviços que promovem o aproveitamento de uma fonte de energia abundante e limpa, que ainda apresenta desafios singulares para ser integrada em capacidade significativa. A produção de som, de forma geral, é encontrada em ambientes naturais e objetos manufaturados, tendo a possibilidade de obtenção dessa energia por meios sequer imaginados até então. Como inspiração, aqui são comentados o sistema auditivo humano e algumas de suas funções, como a conversão de sinais mecânicos para elétricos, auxiliando em uma compreensão elaborada da escuta e carregando oportunidades criativas para formulação de soluções em matéria de geração de energia. Investigando também o fenômeno da piezoeletricidade, as wireless sensor networks e a produção de carga elétrica por meio de materiais sintéticos, abre-se espaço para novas formas de manipular propriedades biológicas. As conclusões aqui presentes são abordagens para as condições de implementação das frequências e ondas sonoras como princípios para um entendimento de uma nova fonte de energia.
TEORIA E PRÁTICA DA EXPERIMENTAÇÃO EM DESIGN ESTRATÉGICO AGENCIADAS POR PROTÓTIPOS ESPECULATIVOS DE FUTUROS
Authors: Barauna Débora , Meyer Guilherme Englert Corrêa
Published: June 2024

Este artigo aborda o problema da construção de conhecimento pelas práticas experimentais em Design estratégico. Para tanto, vamos nos reportar a trabalhos feitos ao longo de três anos com estudantes de Mestrado e Doutorado em Design, enfatizando suas atividades projetuais decorrentes. Os resultados dessas práticas, envolvendo uma série de protótipos e projetos especulativos de futuros, foram todos publicados em um site/blog produzido para a disciplina Experimentação em Design Estratégico da Unisinos. Os materiais publicados, nessa plataforma digital, alimentam a discussão sobre a seguinte questão: que argumentos teórico-práticos da Experimentação em Design Estratégico são revelados pelos projetos e protótipos produzidos?
RACISMO AMBIENTAL NA MODA
Authors: Conceição Maria Eloisa de Jesus , Santos Jorge Roberto Lopes , Magalhães Cláudio Freitas , Franzato Carlo , Poblete Lia Moreira Astudillo
Published: June 2024

O Brasil é um dos líderes em produção de têxteis e confeccionados, mas não apresenta atividade significativa na reciclagem desses produtos. Segundo dados da Associação Brasileira de Empresas de Limpeza Pública e Resíduos Especiais (Abrelpe), o país descarta, anualmente, mais de 4 milhões de toneladas de resíduos têxteis. O impacto ambiental e social resultante dessa prática é uma forma de racismo ambiental, já que o resíduo têxtil acumulado nos lixões e aterros sanitários provoca tragédias que afetam as populações vulnerabilizadas, predominantemente, pretas e pardas, que vivem em áreas de risco com pouco ou nenhum acesso a saneamento básico. A adoção de abordagens de economia circular pode ajudar a reduzir o descarte irregular do material e promover inovação localmente. O presente artigo situa a questão dos resíduos têxteis sob a perspectiva do racismo ambiental, tecendo articulações para imaginar cenários, baseados em estratégias de circularidade que minimizem o descarte e considerem formas de reparar as comunidades prejudicadas.
ESPÉCIES VEGETAIS PARA O ARTESANATO
Authors: Mourão Nadja Maria , De Melo Willian
Published: June 2024

Este trabalho apresenta um breve levantamento das espécies vegetais da mata atlântica e do cerrado mineiro, na Região Metropolitana de Belo Horizonte. Busca-se analisar a viabilidade dessas espécies nativas como matéria-prima para o artesanato, respeitando os biomas locais. Trata-se de uma pesquisa qualitativa, em revisão de literatura. Foram realizados estudos e relatórios individuais das 46 espécies coletadas, por meio de bibliografias que abordam aspectos geográficos, morfológicos e usuais das espécies em questão. São apresentadas algumas espécies, que vão compor um catálogo, contendo o nome popular, nome científico, características e possíveis aplicações das espécies para o artesanato. Acredita-se este trabalho, sob as bases do design, poderá contribuir com a preservação da natureza e da cultura local, incentivando o desenvolvimento de produtos sustentáveis.
Lutas, Artes Marciais e Esportes de Combate do Brasil
Authors: Mocarzel Rafael Carvalho da Silva , Gomes Mariana Simões Pimentel , Rufino Luiz Gustavo Bonatto
Published: June 2024

As lutas, artes marciais e esportes de combate (LAMEC) são práticas corporais socialmente relevantes e estão relacionadas com seus contextos de origem. Dessa forma, é necessário compreender em que medida tais práticas engendram relações com a cultura brasileira. Para isso, objetivou-se apresentar e analisar o panorama histórico e as principais representações sociais e culturais de seis LAMEC popularmente tidas como brasileiras, buscando compreender suas principais características, especificidades e traços de identidade e significação. Por meio de um ensaio teórico, analisou-se especificamente as seguintes práticas: Asamco, Capoeira, Huka-Huka, Jiu-Jitsu Brasileiro, Kombato e a Luta Marajoara. Com base nas análises, conclui-se que a ampliação do respaldo bibliográfico sobre tais LAMEC, muitas das quais ainda são vistas como conhecimentos táticos, pode contribuir com seus processos de desenvolvimento, possibilitando maior fundamentação acerca de suas relações com a cultura brasileira.
Advancements in the Synthesis of Triazolopyrimidines
Authors: Singh Sushma , Lakhia Raman , Yadav Sidhant , Devi Poonam , Yadav Karmvati , Chaudhri Vishwas , Pundeer Rashmi
Published: June 2024

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The triazolopyrimidine scaffold indeed holds a prominent place in medicinal chemistry due to its
versatile pharmacological properties. Researchers have explored the scaffold and its derivatives for various
therapeutic applications. The unique structure of triazolopyrimidine has made it a valuable template for designing medicinally active molecules. The literature is full of studies showcasing the synthesis and biological activities of compounds containing the triazolopyrimidine ring, either fused or coupled with other heterocycles. The
aim of this review is to provide a comprehensive and general summary of the recent advancements in the synthesis of triazolopyrimidine derivatives (Year 2021 to present).
Chitosan/Bioglass Nanocomposites for Bone Tissue Engineering and Regenerative
Medicine: An Overview of Promising Biomaterials
Authors: Khodaverdi Khashayar , Naghib Seyed Morteza , Mozafari M.R.
Published: June 2024

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Bioactive glass (BG) shows great potential as a biomaterial for bone regeneration.
Chitosan enhances the biological characteristics of BG. Chitosan is the sole commonly
utilized natural polysaccharide that may be chemically altered for various purposes and
roles. Composite materials formed by combining chitosan bioactive glass (BG) nanoparticles
and microparticles are used in this context. Integrating bioactive glasses enhances the
mechanical characteristics, bioactivity, and regenerative capacity of the end product. Research
indicates that chitosan/BG composites enhance angiogenesis, cell adhesion, and proliferation.
Bioglass improves biomineralization and boosts bone extracellular matrix formation
by osteoblasts. The current findings demonstrate that the chitosan-glass nanofiber
composites can enhance both antibacterial capabilities and bone conductivity. This review
examines novel techniques for creating chitosan-based materials for engineering purposes, as well as upcoming
difficulties and outlooks.