bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful induction of pseudopregnancy using sonic vibration in mice
Authors: Wake Yui , Endo Marina , Tsunoda Shigemi , Tawara Hirosuke , Abe Hisayuki , Nakagawa Yuki , Kaneko Takehito
Published: March 2023

Embryo transfer (ET) is an essential reproductive technology for the production of new animal strains and maintenance of genetic resources. We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. This study examined the application of this method for the induction of pseudopregnancy in mice. Offspring were obtained from two-cell embryos transferred into females with pseudopregnancy induced using sonic vibration in proestrus on the day before embryo transfer. Furthermore, high developmental rates of offspring were observed when pronuclear and two-cell embryos were transferred to females in estrus that were stimulated on the day of embryo transfer. Genome-edited mice were also obtained using frozen-warmed pronuclear embryos with clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) nucleases introduced using the technique for animal knockout system by electroporation (TAKE) method, which were transferred to females with pseudopregnancy induced on the day of embryo transfer. This study demonstrated that induction of pseudopregnancy by sonic vibration was also possible in mice.
Incidence and predictors of severe postpartum hemorrhage after cesarean delivery in South Central Ethiopia: a retrospective cohort study
Authors: Zewdu Dereje , Tantu Temesgen
Published: March 2023

Severe postpartum hemorrhage is an obstetric emergency that needs immediate intervention and is a leading cause of maternal death. Despite its significant health burden, little is known, about its magnitude and risk factors, especially after cesarean delivery in Ethiopia. This study aimed to evaluate the incidence and predictors of severe postpartum hemorrhage following cesarean section. This study was conducted on 728 women who underwent cesarean section. We retrospectively collected data from the medical records, including baseline characteristics, obstetrics, and perioperative data. Potential predictors were investigated using multivariate logistic regression analyses, adjusted odd ratios, and a 95% confidence interval to see associations. A p-value < 0.05 is considered statistically significant. The incidence of severe postpartum hemorrhage was 26 (3.6%). The independently associated factors were previous CS scar ≥ 2 (AOR 4.08: 95% CI 1.20–13.86), antepartum hemorrhage (AOR 2.89: 95% CI 1.01–8.16), severe preeclampsia (AOR 4.52: 95% CI 1.24–16.46), maternal age ≥ 35 years (AOR 2.77: 95% CI 1.02–7.52), general anesthesia (AOR 4.05: 95% CI 1.37–11.95) and classic incision (AOR 6.01: 95% CI 1.51–23.98). One in 25 women who gave birth during cesarean section experienced severe postpartum hemorrhage. Considering appropriate uterotonic agents and less invasive hemostatic interventions for high-risk mothers would help to decrease its overall rate and related morbidity.
Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation
Authors: Lan Yinghua , Zeng Wen , Wang Yu , Dong Xian , Shen Xiaoping , Gu Yangguang , Zhang Wei , Lu Hongguang
Published: March 2023

Solar ultraviolet (UV) radiation-induced DNA damage is a major risk factor for skin cancer development. UV-induced redistribution of melanin near keratinocyte nuclei leads to the formation of a supranuclear cap, which acts as a natural sunscreen and protects DNA by absorbing and scattering UV radiation. However, the mechanism underlying the intracellular movement of melanin in nuclear capping is poorly understood. In this study, we found that OPN3 is an important photoreceptor in human epidermal keratinocytes and is critical for UVA-mediated supranuclear cap formation. OPN3 mediates supranuclear cap formation via the calcium-dependent G protein-coupled receptor signaling pathway and ultimately upregulates Dync1i1 and DCTN1 expression in human epidermal keratinocytes via activating calcium/CaMKII, CREB, and Akt signal transduction. Together, these results clarify the role of OPN3 in regulating melanin cap formation in human epidermal keratinocytes, greatly expanding our understanding of the phototransduction mechanisms involved in physiological function in skin keratinocytes.
Integrating multiple plant functional traits to predict ecosystem productivity
Authors: Yan Pu , He Nianpeng , Yu Kailiang , Xu Li , Van Meerbeek Koenraad
Published: March 2023

Quantifying and predicting variation in gross primary productivity (GPP) is important for accurate assessment of the ecosystem carbon budget under global change. Scaling traits to community scales for predicting ecosystem functions (i.e., GPP) remain challenging, while it is promising and well appreciated with the rapid development of trait-based ecology. In this study, we aim to integrate multiple plant traits with the recently developed trait-based productivity (TBP) theory, verify it via Bayesian structural equation modeling (SEM) and complementary independent effect analysis. We further distinguish the relative importance of different traits in explaining the variation in GPP. We apply the TBP theory based on plant community traits to a multi-trait dataset containing more than 13,000 measurements of approximately 2,500 species in Chinese forest and grassland systems. Remarkably, our SEM accurately predicts variation in annual and monthly GPP across China (R2values of 0.87 and 0.73, respectively). Plant community traits play a key role. This study shows that integrating multiple plant functional traits into the TBP theory strengthens the quantification of ecosystem primary productivity variability and further advances understanding of the trait-productivity relationship. Our findings facilitate integration of the growing plant trait data into future ecological models.
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
Authors: Srinath Abhinav , Xie Bingqing , Li Ying , Sone Je Yeong , Romanos Sharbel , Chen Chang , Sharma Anukriti , Polster Sean , Dorrestein Pieter C. , Weldon Kelly C. , DeBiasse Dorothy , Moore Thomas , Lightle Rhonda , Koskimäki Janne , Zhang Dongdong , Stadnik Agnieszka , Piedad Kristina , Hagan Matthew , Shkoukani Abdallah , Carrión-Penagos Julián , Bi Dehua , Shen Le , Shenkar Robert , Ji Yuan , Sidebottom Ashley , Pamer Eric , Gilbert Jack A. , Kahn Mark L. , D’Souza Mark , Sulakhe Dinanath , Awad Issam A. , Girard Romuald
Published: March 2023

Background:

Cavernous angiomas (CAs) affect 0.5% of the population, predisposing to serious neurologic sequelae from brain bleeding. A leaky gut epithelium associated with a permissive gut microbiome, was identified in patients who develop CAs, favoring lipid polysaccharide producing bacterial species. Micro-ribonucleic acids along with plasma levels of proteins reflecting angiogenesis and inflammation were also previously correlated with CA and CA with symptomatic hemorrhage.

Methods:

The plasma metabolome of CA patients and CA patients with symptomatic hemorrhage was assessed using liquid-chromatography mass spectrometry. Differential metabolites were identified using partial least squares-discriminant analysis (p < 0.05, FDR corrected). Interactions between these metabolites and the previously established CA transcriptome, microbiome, and differential proteins were queried for mechanistic relevance. Differential metabolites in CA patients with symptomatic hemorrhage were then validated in an independent, propensity matched cohort. A machine learning-implemented, Bayesian approach was used to integrate proteins, micro-RNAs and metabolites to develop a diagnostic model for CA patients with symptomatic hemorrhage.

Results:

Here we identify plasma metabolites, including cholic acid and hypoxanthine distinguishing CA patients, while arachidonic and linoleic acids distinguish those with symptomatic hemorrhage. Plasma metabolites are linked to the permissive microbiome genes, and to previously implicated disease mechanisms. The metabolites distinguishing CA with symptomatic hemorrhage are validated in an independent propensity-matched cohort, and their integration, along with levels of circulating miRNAs, enhance the performance of plasma protein biomarkers (up to 85% sensitivity and 80% specificity).

Conclusions:

Plasma metabolites reflect CAs and their hemorrhagic activity. A model of their multiomic integration is applicable to other pathologies.
Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels
Authors: Patel Meera , Corbett Alexander L. , Vardhan Aarushi , Jeon Keuna , Andoy Nesha May O. , Sullan Ruby May A.
Published: March 2023

Precise control of antimicrobial delivery can prevent the adverse effects of antibiotics.
Antiviral functionalization of a polypropylene nonwoven textile structure as a self-decontaminating layer for respiratory masks
Authors: Maton Mickael , Gabut Sarah , Neut Christel , Odou Pascal , Sacareau Camille , Pinon Anthony , Vialette Michèle , Gerber Gaétan , Martel Bernard , Blanchemain Nicolas
Published: March 2023

The aim of this work was to develop a filtering biocidal polypropylene (PP) nonwoven textile structure to block and inactivate airborne bacteria and viruses.
Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties
Authors: Morrow Joshua P. , Pizzi David , Mazrad Zihnil A. I. , Bush Ashley I. , Kempe Kristian
Published: March 2023

Poly((2-methyl-2-oxazoline)-grad-(2-phenyl-2-oxazoline)) and core-crosslinked micelles thereof are capable of inhibiting ferroptosis, a non-apoptotic iron-induced cell death mechanism.
Particle size optimization of metal–organic frameworks for superior capacitive deionization in oxygenated saline water
Authors: Xing Zhiyuan , Xuan Xiaoxu , Hu Haiyan , Li Mohua , Gao Huimin , Alowasheeir Azhar , Jiang Dong , Zhu Liyang , Li Zhengtong , Kang Yunqing , Zhang Jing , Yi Xibin , Yamauchi Yusuke , Xu Xingtao
Published: March 2023

The effect of metal–organic framework particle size on capacitive performance in oxygenated saline water was studied, suggesting that as particle size increases, the performance decreases.
The first quaternary rare-earth oxythiogermanate with second-harmonic generation and ferromagnetic behavior
Authors: Yang Mei , Yao Wen-Dong , Liu Wenlong , Guo Sheng-Ping
Published: March 2023

The first quaternary rare-earth oxythiogermanate Eu3GeOS4crystallizing in the noncentrosymmetric space groupPca21exhibits a novel 3D structure constructed from unique [EuOS6] and isolated [GeOS3] units, and NLO and ferromagnetic behaviors.
Oxalate-assisted assembly of two polyoxotantalate supramolecular frameworks with proton conduction properties
Authors: Yu Yong , Lai Rong-Da , Sun Cai , Sun Yan-Qiong , Zeng Qing-Xin , Li Xin-Xiong , Zheng Shou-Tian
Published: March 2023

The first two POTa supramolecular frameworks were obtained by using an oxalate-assisted strategy. The frameworks show outstanding proton conductivity. Our strategy opens up a promising avenue for new POTa materials.
Terahertz spectroscopic characterization and DFT calculations of vanillin cocrystals with nicotinamide and isonicotinamide
Authors: Ouyang Jinbo , Xing Xiaohong , Yang Bo , Li Yin , Xu Li , Zhou Limin , Xie Zongbo , Han Dandan
Published: March 2023

Terahertz spectroscopic characterization and DFT calculations of vanillin cocrystals with nicotinamide and isonicotinamide.
Surface charge density governs the ionic current rectification direction in asymmetric graphene oxide channels
Authors: Li Shuang , Zhang Xinke , Su Jiaye
Published: March 2023

In asymmetric graphene oxide channels, the ionic current rectification direction reverses from the negative to positive electric field direction with an increase in surface charge density.
Rational design of formamidine tin-based perovskite solar cell with 30% potential efficiency via 1-D device simulation
Authors: Liang Kaiwen , Huang Like , Wang Tianzhou , Wang Chaofeng , Guo Yi , Yue Yunliang , Liu Xiaohui , Zhang Jing , Hu Ziyang , Zhu Yuejin
Published: March 2023

A rational design of low bandgap formamidine tin based perovskite solar cell is conducted via device simulation. The device parameters that influence the device performance are comprehensively investigated and optimized for higher performance.
A computational study of the reaction mechanism and stereospecificity of dihydropyrimidinase
Authors: Meelua Wijitra , Wanjai Tanchanok , Thinkumrob Natechanok , Oláh Julianna , Cairns James R. Ketudat , Hannongbua Supa , Ryde Ulf , Jitonnom Jitrayut
Published: March 2023

DFT calculations reveal mechanistic insights and different preferences in the substrate specificity of the dihydropyrimidinase from yeast and bacteria as well as the role of stereo-gate-loop residues in the stereospecificity of catalysis.
A new look at the structure of the neutral Au18 cluster: hollow versus filled golden cage
Authors: Nhat Pham Vu , Si Nguyen Thanh , Fielicke André , Kiselev Vitaly G. , Nguyen Minh Tho
Published: March 2023

The geometry of the neutral Au18 gold cluster was probed by a combination of quantum chemical calculations and far-infrared multiple photon dissociation (FIR-MPD) spectroscopy of a Kr messenger complex.
Tuning the water-splitting mechanism on titanium dioxide surfaces through hydroxylation
Authors: Wu Lu , Liao Meijing , Zhao Bing , Li Qianni , Liu Bin , Zhang Yuexing
Published: March 2023

DFT investigations on mechanism of water oxidation and product selectivity of six types of hydroxylated TiO2 surfaces reveal the variation and significant roles of hydroxyl groups, providing a new method for tuning the water-splitting mechanism.
Satellite ligand effects on magnetic exchange in dimers. A structural, magnetic and theoretical investigation of Cu2L2X4 (L = methylisothiazolinone and X = Cl−, Br−)
Authors: Coetzee Stefan , Turnbull Mark M. , Landee Christopher P. , Monroe Jeffrey C. , Deumal Mercè , Novoa Juan. J. , Rademeyer Melanie
Published: March 2023

The orientation of the terminal/satellite L ligands in stacked-dimer Cu2X4L2 polymers is shown to affect the magnetic exchange in and between dimers. This information introduces an additional design tool to tune the magnetic exchange from AFM to FM.
Dipolar field effects in a solid-state NMR maser pumped by dynamic nuclear polarization
Authors: Chacko Vineeth Francis Thalakottoor Jose , Abergel Daniel
Published: March 2023

We report the observations and the analysis of a pulsed solid state sustained maser generated by proton spins hyperpolarized by Dynamic Nuclear Polarization (DNP) at 1.2 K. Observations are rationalized in terms of radiation damping and dipolar field effects.
Photolithographic microfabrication of hydrogel clefts for cell invasion studies
Authors: Stöberl Stefan , Balles Miriam , Kellerer Thomas , Rädler Joachim O.
Published: March 2023

We present microfabricated hydrogel clefts, ‘sponge clamps’, made of polyethylene glycol-norbornene (PEG-NB) with defined geometry, stiffness and adhesiveness for the study of cell invasion.
pH-Responsive wound dressings: advances and prospects
Authors: Han Zeyu , Yuan Mujie , Liu Lubin , Zhang Kaiyue , Zhao Baodong , He Bin , Liang Yan , Li Fan
Published: March 2023

This review focuses on the design strategies and advanced functions of pH-responsive wound dressings, and makes a systematic discussion of the challenges and future development trends in this field.
Microfluidic production of nanogels as alternative triple transfection reagents for the manufacture of adeno-associated virus vectors
Authors: Whiteley Zoe , Massaro Giulia , Gkogkos Georgios , Gavriilidis Asterios , Waddington Simon N. , Rahim Ahad A. , Craig Duncan Q. M.
Published: March 2023

Microfluidic produced nanogels provide an alternative to standard transfection reagents for the manufacture of adeno-associated viral vectors (AAVs), with equivelant viral titres demonstrated.
Tuning water chemistry for the recovery of greener products: pragmatic and sustainable approaches
Authors: Adeeyo A. O. , Oyetade J. A. , Alabi M. A. , Adeeyo R. O. , Samie A. , Makungo R.
Published: March 2023

The environmental impact and denaturing propensity of organic solvents in the extraction of plant bioactives pose great challenges in extraction systems.
Explication of mechanism governing atmospheric degradation of 3D-printed poly(lactic acid) (PLA) with different in-fill pattern and varying in-fill density
Authors: Chopra Swamini , Pande Kavita , Puranam Priadarshni , Deshmukh Abhay D. , Bhone Avinash , Kale Rameshwar , Galande Abhishek , Mehtre Balaji , Tagad Jaydeep , Tidake Shrikant
Published: March 2023

With accelerated weathering test instruments lacking the ability to correlate with actual instabilities during application, this work makes an attempt to explore the degradation of PLA under natural atmospheric conditions of UV, rain and humidity.
Ocular protein optineurin shows reversibility from unfolded states and exhibits chaperone-like activity
Authors: Dixit Anjali , Chakraborty Ankan , Nath Jyoti Rani , Chowdhury Pramit K. , Kundu Bishwajit
Published: March 2023

Hexameric optineurin (OPTN) is not dissociated into monomers by chemical denaturants, forms reversible multimers upon thermal denaturation and shows chaperoning activity by reducing the thermal aggregation of bovine carbonic anhydrase (BCA).
Cobalt-catalyzed radical-mediated carbon–carbon scission via a radical-type migratory insertion
Authors: Liu Jian-Biao , Liu Xiao-Jun , Oliveira João C. A. , Chen De-Zhan , Ackermann Lutz
Published: March 2023

An unconventional radical-type migratory insertion mechanism was identified, leading to a distinct cobalt-catalyzed radical-mediated carbon–carbon cleavage for alkylidenecyclopropanes.
Salicylic acid treated Li7La3Zr2O12 achieves dual functions for a PEO-based solid polymer electrolyte in lithium metal batteries
Authors: He Wen , Ding Hui , Li Chuandong , Chen Xu , Yang Wensheng
Published: March 2023

A new approach to treat LLZO particles with salicylic acid (SA) to achieve dual-functionalization. This interfacial modification technique enhances Li+ transport not only at the LLZO/PEO interface, but also throughout the PEO matrix.
3D direct ink printed materials for chemical conversion and environmental remediation applications: a review
Authors: Tan Jeannie Z. Y. , Ávila-López Manuel Alejandro , Jahanbakhsh Amir , Lu Xuesong , Bonilla-Cruz José , Lara-Ceniceros Tania E. , Andresen John M. , Maroto-Valer M. Mercedes
Published: March 2023

3D printing technologies and continuous flow microreaction systems are rapidly gaining attention in the domain of heterogeneous catalysis.
Effects of surface acidity on the structure of organometallics supported on oxide surfaces
Authors: Samudrala Kavyasripriya K. , Conley Matthew P.
Published: March 2023

Well-defined organometallic cations supported on high surface area oxides are promising heterogeneous catalysts.
Fabrication of a Cd(ii) metal–organic framework as a dual functional material: efficient iodine capture and selective adsorption of a cationic dye
Authors: Vakil Farhat , Ahmad M. Shahwaz , Kumar Manjeet , Ansari Azaj , Shahid M. , Ahmad Musheer
Published: March 2023

A Cd-based MOF with a rare dmc topology is fabricated in order to tune it for effective iodine capture and selectively adsorb a cationic dye.
Growth and characterization of the β-Ga2O3 (011) plane without line-shaped defects
Authors: Chen Boyang , Mu Wenxiang , Liu Yiyuan , Wang Pei , Ma Xu , Zhang Jin , Dong Xuyang , Li Yang , Jia Zhitai , Tao Xutang
Published: March 2023

The β-Ga2O3 (011) plane could be a potential substrate orientation for power devices because it avoids a kind of dislocation which leads to leakage current and breakdown of power devices as the dislocations propagate parallel to the (011) plane.
Complementary host behaviour of three anthracenyl-derived roof-shaped compounds in mixed pyridines
Authors: Barton Benita , Caira Mino R. , Senekal Ulrich , Hosten Eric C.
Published: March 2023

Three roof-shaped host compounds possessed complementary selectivity behaviour in mixed pyridines. This stereoview shows the inclusion of a pair of guest molecules by six host molecules in H3·2MePy. (Guest carbon atoms are in black for contrast).
An investigation of the selectivity behaviour of host compound (R,R)-(−)-2,3-dimethoxy-1,1,4,4-tetraphenylbutane-1,4-diol in mixed cresols
Authors: Barton Benita , Pohl Pieter L. , Hosten Eric C.
Published: March 2023

(R,R)-(−)-2,3-Dimethoxy-1,1,4,4-tetraphenylbutane-1,4-diol (H2) retains 2-cresol (2Cr) in the 2(H2)·2Cr complex by means of a unique (guest)O–H⋯π(host) interaction.
Synthesis, X-ray characterization and DFT calculations of a series of 3-substituted 4,5-dichloroisothiazoles
Authors: Kolesnik Irina A. , Potkin Vladimir I. , Grigoriev Mikhail S. , Novikov Anton P. , Gomila Rosa M. , Podrezova Alexandra G. , Brazhkin Vadim V. , Zubkov Fedor I. , Frontera Antonio
Published: March 2023

This manuscript reports the synthesis and X-ray characterization of a series of 3-substituted 4,5-dichloroisothiazoles and the analysis of recurrent motifs.
Application of the real space decimation method in determining intricate electronic phases of matter: a review
Authors: Mukherjee Amrita , Bandyopadhyay Arka , Jana Debnarayan
Published: March 2023

Real space decimation technique is an elegant and handy tool to reveal the exotic electronic phases of matter, ranging from the dispersionless flat band to the linear dispersive Dirac systems.
Ruthenium(ii) arene complexes bearing simple dioxime ligands: effective catalysts for the one-pot transfer hydrogenation/N-methylation of nitroarenes with methanol
Authors: Colaiezzi Roberta , Saviozzi Chiara , di Nicola Nicola , Zacchini Stefano , Pampaloni Guido , Crucianelli Marcello , Marchetti Fabio , Di Giuseppe Andrea , Biancalana Lorenzo
Published: March 2023

Ruthenium(ii) η6-arene complexes with easily-available dioxime ligands are efficient catalytic precursors for the selective reduction/N-methylation of aromatic nitrocompounds with methanol.
Visible-light-driven anaerobic oxidative upgrading of biomass-derived HMF for co-production of DFF and H2 over a 1D Cd0.7Zn0.3S/NiSe2 Schottky junction
Authors: Shan Tao , Luo Luteng , Chen Taoran , Deng Lixun , Li Mengqing , Yang Xuhui , Shen Lijuan , Yang Min-Quan
Published: March 2023

A 1D Cd1−xZnxS/NiSe2 Schottky junction that combines the structural and functional advantages of 1D rod with metal-like selenide is constructed, which shows high selectivity and efficient utilization of electron-hole pairs for anaerobic oxidation of HMF to DFF and H2.
Recent progress with the application of organic room-temperature phosphorescent materials
Authors: Ji Mengxing , Ma Xiang
Published: March 2023

A summary of recent progress with the application of organic room-temperature phosphorescent materials in luminescence and display, environmental detection and bioimaging.
Correction: Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions
Authors: Verhulsel Marine , Simon Anthony , Bernheim-Dennery Moencopi , Gannavarapu Venkata Ram , Gérémie Lauriane , Ferraro Davide , Krndija Denis , Talini Laurence , Viovy Jean-Louis , Vignjevic Danijela Matic , Descroix Stéphanie
Published: March 2023

Correction for ‘Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions’ by Marine Verhulsel et al., Lab Chip, 2021, 21, 365–377, https://doi.org/10.1039/d0lc00672f.
Angle-resolved plasmonic photocapacitance of gold nanorod dimers
Authors: Pal Sudip Kumar , Bardhan Dorothy , Sen Debarun , Chatterjee Hirak , Ghosh Sujit Kumar
Published: March 2023

The correspondence between plasmonics and electronics has been determined through the mechanics of gold nanorod dimers from both theoretical and experimental perspectives.
Structural, magnetic and phase transition properties in S = ½ radical solid solutions of [FxCl1−x-BzPy][Ni(mnt)2] (x = 0.07–0.87)
Authors: Yao Wan-Wan , Ma Bin-Bin , Xu Lei , Shao Dong-Sheng , Qian Yin , Liu Wen-Long , Ren Xiao-Ming
Published: March 2023

The S = ½ spin chain salts [FxCl1−x-BzPy][Ni(mnt)2] (0–1) show a phase transition, and an anomalous change of TC and J/kB with x.
The role of nanocerianite (CeO2) in the stability of Ce carbonates at low-hydrothermal conditions
Authors: Szucs Adrienn Maria , Maddin Melanie , Brien Daniel , Rateau Remi , Rodriguez-Blanco Juan Diego
Published: March 2023

Cerianite (CeO2) crystals obtained during synthesis in solution-based and solution-mediated replacement experiments.
Dynamic bond interactions fine-tune the properties of multiple resonance emitters towards highly efficient narrowband green OLEDs
Authors: Zou Yang , Yu Mingxin , Miao Jingsheng , Huang Taian , Liao Shuokun , Cao Xiaosong , Yang Chuluo
Published: March 2023

This work reported a series of pyridine modified multiple resonance emitters. The dynamic bond interactions brought by the pyridine moiety endowed the emitters with superb photophysical properties and excellent device performance.
Synthesis, bridgehead functionalization, and photoisomerization of 9,10-diboratatriptycene dianions
Authors: Prey Sven E. , Gilmer Jannik , Teichmann Samira V. , Čaić Luis , Wenisch Mischa , Bolte Michael , Virovets Alexander , Lerner Hans-Wolfram , Fantuzzi Felipe , Wagner Matthias
Published: March 2023

9,10-Diboratatriptycene dianions were synthesized via [4 + 2] cycloaddition between 9,10-dihydro-9,10-diboraanthracene dianions and benzyne. We show bridgehead chlorination, Me2S-adduct formation, and photorearrangement to diborabenzo[a]fluoranthenes.
A biocompatible cell cryoprotectant based on sulfoxide-containing amino acids: mechanism and application
Authors: Liu Min , Chen Changhong , Liang Lei , Yu Chaojie , Guo Bingyan , Zhang Haitao , Qiu Yuwei , Zhang Hong , Yao Fanglian , Li Junjie
Published: March 2023

l-methionine sulfoxide (Met(O)–OH) as a CPA for cell cryopreservation.
Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents
Authors: Sun Zeyi , Li Tieyan , Mei Tianxiao , Liu Yang , Wu Kerui , Le Wenjun , Hu Yihui
Published: March 2023

Metal–organic frameworks (MOFs) hold great promise for widespread applications in biomedicine and nanomedicine.
A tri‐level optimization strategy incorporating wind power against coordinated cyber‐physical attacks
Authors: Li Shihao , Shi Libao
Published: March 2023

With the fast development of cyber‐physical power systems, coordinated cyber‐physical attacks have become one of the main threats to the security of modern power grid. Considering that it is difficult for attackers to obtain full information of the entire power grid, the coordinated cyber‐physical attack problem for partitioned power grid is studied in this paper, and a tri‐level defender‐attacker‐dispatcher optimization model with consideration of wind power uncertainty in a specific coordinated cyber‐physical attack mode is proposed. The Karush‐Kuhn‐Tucker (KKT) condition and an improved implicit enumeration algorithm are applied to obtain the solution of the complicated optimization problem effectively. In addition, two risk assessment indices pertinent to the physical lines and load measurements are proposed according to the obtained total amount of optimized load shedding and coordinated attack‐defense strategy under valid attack‐defense scenarios. Taking a partitioned IEEE 39‐bus test system as example, the risks of physical transmission lines and load measurements in different areas under attacks are elaborately studied, and the impact of wind power uncertainty on attack‐defense strategies is discussed as well. Numerical simulation results illustrate the effectiveness of the proposed optimization model and risk assessment indices, and some significant conclusions are drawn.
Optimal design method of public transit network considering transfer efficiency
Authors: Jing Dian , Yao Enjian , Chen Rongsheng , Sun Xun
Published: March 2023

Improving the sharing rate of public transport and reducing operation costs are key factors affecting the sustainable development of the public transport system. After quantifying the impact of transfer, this study proposes a multi‐objective optimization model of bus networks considering the integral transfer efficiency and operation costs, whose optimal solution is hard to find. Since the heuristic algorithm has great global searchability, a non‐dominated sorted genetic algorithm (NSGA‐II) is adopted to solve this NP‐hard problem. Also, an adaptive mutation mode selection algorithm is proposed to enhance the solution efficiency. The optimization framework is applied to the benchmark case of the Swiss public transit network. The results show that the method significantly improves the transfer efficiency of the designed network when compared to existing studies. After calculation, it is found that enhancing the direct rate can improve transfer efficiency, but with high costs. Moreover, the proposed method can design an efficient and economic network to balance the benefits of passengers and operators in practice.
The role of performance analysis within the coaching process: Dealing with failure in volleyball side out attack
Authors: Degrenne Olivier , Langlois Vincent , Paulo Ana , Éloi Serge , Mouchet Alain
Published: March 2023

Performance analysis has been a key-element in team sports such as volleyball for a long time, playing a role in the coaches’ learning through the association of their lived coaching experience with objective data. A discriminant performance indicator on winning a volleyball set is the effectiveness of attack after reception – i.e., side out attack. So, it is important for coaches’ future interventions to identify how expert setters deal with unsuccessful side out attacks. Thus, the aim of the present study was to analyze, in an elite level competitive context, the setter’s decision making after a failed side out attack. A total of 44 matches were analyzed from the 2014 and the 2018 Men’s World Championships and the 2016 Olympic Games. The sample included all lost side out sequences (SO1), followed by the subsequent side out play (SO2), which resulted in a final sample of 499 “side out” sequences. Results indicated that after a failed side out, using a faster attack tempo was the best way to win the rally, and that in more than half of the sample, setters inverse their setting from SO1 to SO2. Our findings are informative for volleyball coaching, specifically for setting practice, athlete development, in-game decision making and scouting.
Mise en œuvre d’un programme d’activité physique adaptée chez les patients atteints de cancer : amélioration de leur qualité de vie, de leur fatigue et de leur capacité physique
Authors: Ralec Charlotte , Creff Laurent , Verdun Stéphane , Buyse Marion , Bouée Jean-Baptiste
Published: March 2023

Introduction : Les bénéfices de l’activité physique dans la prise en charge globale en cancérologie sont maintenant reconnus. Malheureusement, l’offre de soin reste encore trop limitée et peu standardisée. Objectif : Cette étude vise à évaluer le programme d’activité physique adaptée (APA) développé au sein de notre institut en comparant les niveaux de qualité de vie, de fatigue, d’activité physique et de sédentarité ainsi que des capacités physiques à l’entrée et à la sortie du séjour de réadaptation. Méthode : Étude rétrospective sur les patients (n = 72) ayant suivi le programme d’APA entre août 2019 et avril 2021. La fatigue ressentie était déterminée par l’échelle FSS (Fatigue Severity Scale), la qualité de vie par le questionnaire MOS-SF36 (santé physique et mentale), et les capacités physiques par le TM6 (test de marche des 6 minutes). L’analyse statistique de l’évolution des paramètres étudiés a été réalisée par un test de Student apparié en cas de normalité des données ou par un test de Wilcoxon dans le cas contraire. Résultats : À la suite des 24 demi-journées du programme de réadaptation, on observait une diminution significative de la fatigue ressentie (4,3 ± 1,6 vs. 3,3 ± 1,4 ; p < 0,0001***), une amélioration de la qualité de vie évaluée par le questionnaire MOS-SF36 (score physique, mentale et santé perçue) ainsi que des capacités physiques (432 ± 115,3 vs. 490,8 ± 100,5 m ; p < 0,0001***) des patients. Conclusion : Cette expérience pilote permet de valider les bénéfices globaux de notre programme d’APA chez les patients atteints de différent type de tumeur maligne.
Liebe Leserinnen und Leser,
Authors: Joisten Christine
Published: March 2023

„Exercise is medicine“ oder „Bewegung als Medikament“
ist ein immer wieder aktueller Slogan, auch in der Prävention und Therapie
von Übergewicht und Adipositas bzw. den damit verbundenen Begleit- und
Folgeerkrankungen. Sicherlich ist Bewegung stets in Verbindung mit den anderen
Therapiesäulen, insbesondere Ernährung und Verhalten, zu betrachten.
Der Schwerpunkt dieses Heftes liegt aber v. a. auf Bewegung und Sport bei
verschiedenen Zielgruppen. Denn zur Diskussion stehen immer wieder die richtige
„Dosis“ und der erschwerte Einstieg.
Adipositas und Schwangerschaft – Rolle der
körperlichen Aktivität
Authors: Ferrari Nina , Joisten Christine
Published: March 2023

Körperlicher Aktivität vor als auch während der
Schwangerschaft hat zahlreiche positive Effekte auf Mutter und Kind. Allerdings
erreichen in Deutschland weniger als die Hälfte der Frauen im
Erwachsenenalter die Aktivitätsempfehlungen der
Weltgesundheitsorganisation, sich mindestens 150 Minuten in moderater
Ausdaueraktivität zu betätigen. In der Schwangerschaft wird die
Aktivitätszeit noch weiter reduziert. Kombiniert mit Übergewicht
oder Adipositas in der Schwangerschaft hat dies Auswirkungen auf die
mütterliche als auch auf die kindliche Gesundheit. Auf Basis der
aktuellen Literatur sollen daher beispielhaft die Effekte von Bewegung
während der Schwangerschaft auf Mutter und Kind im Kontext Adipositas
zusammengestellt sowie die aktuellen Empfehlungen zu Bewegung in dieser
Zielgruppe beschrieben werden. Darüber hinaus wird auf die potentiellen
zugrundeliegenden Mechanismen eingegangen.
Die Rolle der körperlichen Aktivität im Kontext der
bariatrischen Chirurgie
Authors: Notz Sara Johanna , Mann Oliver , Plitzko Gabriel
Published: March 2023

Die Prävalenz der Adipositas steigt seit mehreren Jahrzehnten. Damit
einhergehend steigt die Anzahl der jährlich durchgeführten
bariatrischen Operationen sukzessive an. Die deutsche S3-Leitlinie
„Chirurgie der Adipositas und metabolischer Erkrankungen“
empfiehlt präoperativ für die meisten Patienten eine multimodale
Therapie, die auch eine Bewegungstherapie beinhaltet. Eine solche strukturell
verankerte Bewegungstherapie findet sich in den Empfehlungen zur Nachsorge
nicht. Eine alleinige Bewegungstherapie führt präoperativ in
aller Regel nicht zu signifikanten Gewichtsreduktion. Dies ist jedoch bei einem
Teil der Patienten möglich in Kombination mit einer Ernährungs-
und/oder Verhaltenstherapie. Durch eine Bewegungstherapie kann jedoch
eine über den Zeitpunkt der Operation hinausreichende, erhöhte
körperliche Aktivität erreicht werden, die sich positive auf
einen möglichen Weight Regain auswirkt. Für den Einfluss einer
Bewegungstherapie nach einem bariatrischen Eingriff auf den Gewichtsverlust ist
die Datenlage widersprüchlich. Allerdings wirkt sie sich ebenso wie die
präoperative Bewegungstherapie positiv auf einen Weight Regain aus.
Darüber hinaus scheint ein positiver Einfluss auf die Knochendichte und
somit auf das nach bariatrischen Operationen erhöhte Frakturrisiko zu
bestehen.
Die Rolle des Oxytocinsystems für die Entstehung der Depression
Authors: Sanwald Simon , Kammer Thomas , Montag Christian , Kiefer Markus
Published: March 2023

Oxytocin erregte aufgrund seiner Rolle für das menschliche Sozialverhalten in den letzten Jahren vermehrt Aufmerksamkeit hinsichtlich der Erforschung der Ätiologie depressiver Erkrankungen. Aktuelle Forschungsergebnisse legen die Komplexität des Oxytocinsystems und sowohl pro- als auch antisoziale Effekte des Neuropeptids offen, weshalb seine Rolle für die Salienz sozialer Reize oder allgemeiner für allostatische Prozesse diskutiert wird. Diese Arbeit fasst Befunde zu den Zusammenhängen zwischen Oxytocin und belastenden Lebensereignissen sowie zwischen Oxytocin und der Verstärkung sozialer Interaktionen zusammen. Ausgehend von diesen Verknüpfungen des Oxytocinsystems mit dem körperlichen Stresssystem und dem Belohnungssystem stellt diese Arbeit einen Versuch dar, aktuelle Theorien zur Funktion von Oxytocin auf die Depression anzuwenden, um so eine Hypothese zur Rolle des Oxytocinsystems hinsichtlich des Ursprungs der biologischen und behavioralen Korrelate dieser Störung aufzustellen.
Hoffnung für Zöliakie-Patienten: Transglutaminase-Hemmer als medikamentöse Therapieoption?
Authors: Uecker Christine , Langhorst Jost
Published: March 2023

Die Zöliakie ist eine angeborene Autoimmunerkrankung, die unentdeckt und unbehandelt zu einer Vielzahl von Symptomen, entzündungsbedingten Schäden der Dünndarmschleimhaut und schwerwiegenden Folgeerkrankungen führen kann. Auslöser der Erkrankung ist die Aufnahme von Gluten über Nahrungsmittel. Bislang bestand die einzige zuverlässig wirksame Therapieoption in der lebenslangen strikten Einhaltung einer glutenfreien Diät. Aktuell werden Medikamente in Studien erprobt, die möglicherweise die negativen Auswirkungen der Glutenaufnahme auf die Dünndarmschleimhaut und die Symptomatik verringern bzw. verhindern.
Böser Weizen? Mehr als nur Gluten-Quelle
Authors: Ots Thomas
Published: March 2023

Industriell angebauter Weizen hat sich in den vergangenen Jahrzehnten stark gewandelt. Moderne Weizensorgen haben einen höheren glykämischen Index als Haushaltszucker. Der übermäßige Weizenverzehr bewirkt daher massive Blutzuckerspitzen, bei denen kurzfristige Sättigung sich mit erhöhtem Appetit abwechselt. Er begünstigt entzündliche Reaktionen sowie eine fehlgeleitete Immunmodulation. Weizen kann regelrecht süchtig machen. Ihn durch andere Getreidesorten zu ersetzen, wäre eine Möglichkeit, die Ernährungsgewohnheiten sinnvoll umzustellen.
Das entfremdete Selbst, die entfremdete Umwelt
Authors: Macchia Ana , Malejko Kathrin , Abler Birgit
Published: March 2023

Obwohl Dissoziation einer der ältesten Forschungsgegenstände der Psychiatrie darstellt, bleibt sie bis heute ein vage definiertes und mannigfaltiges Konstrukt. Ausgeprägte dissoziative Symptome sind für eine Subgruppe von Patienten mit Borderline-Persönlichkeitsstörung (BPS) und posttraumatischer Belastungsstörung (PTBS) charakteristisch und von hoher klinischer Relevanz mit Prävalenzen von 19–34 % bei BPS und bis zu 60 % bei PTBS. Insbesondere Veränderungen der psychischen Integrität mit einer Entfremdung von Selbst und Umwelt (Derealisation/Depersonalisation) gehen mit einer ausgeprägteren BPS- und PTBS-Symptomatik sowie riskanten Verhaltensweisen wie Selbstverletzung und Suizidalität einher. Dissoziative Symptome können nach dem aktuellen Kenntnisstand als eine unwillkürliche und automatische maladaptive Form der Emotionsregulation eingestuft werden, bei welcher subjektiv eine Distanz zu internalen oder externalen bedrohlichen Ereignissen hergestellt wird, die aber objektiv mit einer erhöhten Stressreaktion und autonomer Erregung aufzutreten scheint. Insbesondere bei der BPS wirken sich dissoziative Symptome negativ auf das Behandlungsergebnis aus, während die konkrete Adressierung von Dissoziationen beispielsweise durch Psychoedukation, Achtsamkeit oder Fertigkeitentraining Therapieerfolge verbessert.
Therapiekonzepte der anthroposophischen Medizin bei Allergien
Authors: Roemer Franziska
Published: March 2023

Die Zahl der von saisonalen Allergien Betroffenen nimmt jedes Jahr zu. Der erste Griff ist dann meist zu OTC-Medikamenten, die aber den Körper nicht nur belasten können, sondern die auch keine Heilung erzielen. Die Anthroposophische Medizin mit ihren vielfältigen Möglichkeiten bietet bei Allergien jedoch einen schonenden und dabei äußerst umfassenden und wirksamen Ansatz.
Relationship Between Body Size and Skeletal Age with Muscle Damage in
Young Soccer Players
Authors: Ramos-Silva Luiz Fernando , Costa Julio Cesar , Borges Paulo Henrique , Moura Felipe A , Deminice Rafael , de Oliveira Donizete Cícero Xavier , Osiecki Raul , Vaz Ronque Enio Ricardo
Published: March 2023

This study verified the relationship between body size and skeletal age (SA) with
the behavior of blood markers of muscle damage and delayed onset muscle soreness
(DOMS) after a soccer match in the U-13 and U-15 categories. The sample
consisted of 28 soccer players in the U-13 and 16 in the U-15 categories.
Creatine kinase (CK), lactate dehydrogenase (LDH), and DOMS were evaluated up to
72 h after the match. Muscle damage was elevated at 0 h in U-13,
and from 0 h to 24 h in U-15. DOMS increased from 0 h to
72 h in U-13 and from 0 h to 48 h in U-15. Significant
associations of SA and fat-free mass (FFM) with muscle damage markers and DOMS
were observed only in U-13, specifically at time 0 h, when SA explained
56% of CK and 48% of DOMS and FFM explained 48% of DOMS.
We concluded that in the U-13 category, higher SA is significantly associated
with muscle damage markers, and increase in FFM is associated with muscle damage
markers and DOMS. Furthermore, U-13 players need 24 h to recover
pre-match muscle damage markers and more than 72 h to recover DOMS. In
contrast, the U-15 category needs 48 h to recover muscle damage markers
and 72 h to recover DOMS.
Clinicopathological Significance and Prognostic Role of Her2neu Protein Expression in Patients with Carcinoma Stomach: A Prospective Study from Northern India
Authors: B. Abhilash V. , Behera Manas Kumar , Patne Shashikant C. U. , Shukla Sunit Kumar , Dixit Vinod Kumar
Published: March 2023

Background and Aims Gastric cancer is the third most common cause of cancer-related mortality worldwide after lungs and colorectum. Although controversial, Her2neu overexpression by immunohistochemistry is usually associated with poor prognosis in patients with carcinoma stomach. We conducted a prospective study to evaluate the prognostic role of Her2neu and its correlation with clinical, pathologic type, and stage of the disease.

Methods A prospective study was performed on paraffin blocks of 111 gastric cancer specimens (88 patients were biopsy specimens and 23 were gastrectomy specimens). The paraffin blocks were processed for Her2neu receptor immunohistochemical staining and fluorescence in situ hybridization, and scoring was done.

Results Her2neu overexpression was detected in 30 out of 111 (27%) patients. The mean age was 57.68 ± 12.82 years, with males constituting two-thirds of total patients. Tobacco addiction was found in 44% of the patients and smoking in 33% of the patients. Her2neu expression was similar in Lauren's intestinal and diffuse histologic type; however, proximal gastric tumors overexpressed Her2neu as compared with distal tumors. Her2neu 2+ or 3 + (odds ratio: 2.52, 95% CI: 1.61–3.95, p = 0.001) was the only independent predictor of survival in gastric cancer patients. Kaplan–Meir survival analysis showed that the survival of gastric cancer patients with Her2neu overexpression (Her2neu 2+ or 3 + ) was significantly lower than that of those with Her2neu nonexpression (p = 0.001).

Conclusion Her2neu positivity was a significant predictor of mortality in patients with carcinoma stomach, and Her2neu overexpression was associated with a lower overall survival rate compared with Her2neu nonexpression.
MR Imaging of the Developing Pediatric Marrow: An Overview of Pearls and Pitfalls
Authors: Igbinoba Zenas , Jaramillo Diego
Published: March 2023

The dynamic and developing pediatric skeleton is a well-elucidated process that occurs in a stepwise faction. Normal development has been reliably tracked and described with Magnetic Resonance (MR) imaging. The recognition of the normal patterns of skeletal development is essential, as normal development may mimic pathology and vice versa. The authors review normal skeleton maturation and the corollary imaging findings while highlighting common marrow imaging pitfalls and pathology.
Ab initiomolecular dynamics study of dissociative adsorption of H2 on defective graphene-supported Cu19 cluster
Authors: Liu Naigui , Gao Delu , Wang Dunyou
Published: March 2023

The dissociative adsorption of H2 on Cu19 and defective graphene-supported Cu19 clusters (Cu19G) are investigated using ab initio molecular dynamics. The molecular-level trajectories show that, on Cu19, the preferred adsorption site is the bridge-hollow site, where the two H atoms are adsorbed at the bridge and hollow sites beside a Cu atom, with an adsorption energy of −0.74 eV. In contrast, on the defective graphene-supported Cu19 cluster, the favorite adsorption site is located where the two H atoms are adsorbed at hollow-hollow sites with an adsorption energy of −1.27 eV. In general, the average adsorption energy on the defective graphene-supported Cu19 cluster is −1.07 eV, which is about 84% larger than that of −0.58 eV on the Cu19 cluster. This indicates that the adsorption capacity is greatly enhanced for the dissociative adsorption of H2 on the defective graphene-supported Cu19 cluster. The d-band center shifts to the Fermi level, illustrating the enhanced adsorption capacity on the defective graphene-supported Cu19 cluster. The integrated crystal orbital Hamilton population analysis reveals that stronger bond interactions between hydrogen atoms with their bonded Cu atoms lead to much larger adsorption energies on the defective graphene-supported Cu19 cluster compared to the Cu19 cluster.
Bidirectional transmission of a collimator with double-combined collimating lenses and thermally expanded core fibers
Authors: Zhao Zhengang , Duan Shaofeng , Xu Xiaoping , Wang Sifei , Wan Xiaorong
Published: March 2023

The collimator is an essential part of the fiber optic rotary joint design. This study proposes the Large-Beam Fiber Collimator (LBFC) with a double collimating lens and a Thermally Expanded Core (TEC) fiber structure. The transmission model is constructed based on the defocusing telescope structure. The effects of TEC fiber’s mode field diameter (MFD) on the coupling loss are investigated by deriving the loss function for the influence of collimator mismatch error and implementing it on a fiber Bragg grating temperature sensing system. The experimental results show that the coupling loss decreases with the increase of the MFD of TEC fiber, while the coupling loss is less than 1 dB when the mode field diameter is greater than 14 µm. TEC fibers can reduce the effect of angular deviation. Considering the coupling efficiency and deviation, the preferred mode field diameter for the collimator is 20 µm. The proposed LBFC enables bidirectional transmission of optical signals for temperature measurement.