bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural Preferences and Vibrational Analysis of 2-Hydroxy-2-methyl-1-phenylpropan-1-one: A Computational and Infrared Spectroscopic Research
Authors: Belaidi O. , Bouchaour T. , Maschke U.
Published: May 2013

The Fourier transform infrared (FTIR) spectrum of 2-hydroxy-2-methyl-1-phenylpropan-1-one has been measured in the region 4000–700 . The most stable conformation of title molecule was found after a careful potential energy surfaces study. The molecular geometry, vibrational frequencies, and infrared intensities have been calculated by using ab initio HF and density functional theory calculation B3LYP with 6-311+ basis set. Scaled frequencies and potential energy distribution were calculated for band assignment. We found an excellent agreement between the experimental and the simulated spectra. Energy gap between HOMO and LUMO explains the eventual charge transfer interactions taking place within the molecule.
Phase II Study of Lutetium-177–Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer
Authors: Tagawa Scott T. , Milowsky Matthew I. , Morris Michael , Vallabhajosula Shankar , Christos Paul , Akhtar Naveed H. , Osborne Joseph , Goldsmith Stanley J. , Larson Steve , Taskar Neeta Pandit , Scher Howard I. , Bander Neil H. , Nanus David M.
Published: May 2013

Purpose: To assess the efficacy of a single infusion of radiolabeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 (lutetium-177; 177Lu) by prostate-specific antigen (PSA) decline, measurable disease response, and survival.

Experimental Design: In this dual-center phase II study, two cohorts with progressive metastatic castration-resistant prostate cancer received one dose of 177Lu-J591 (15 patients at 65 mCi/m2, 17 at 70 mCi/m2) with radionuclide imaging. Expansion cohort (n = 15) received 70 mCi/m2 to verify response rate and examine biomarkers.

Results: Forty-seven patients who progressed after hormonal therapies (55.3% also received prior chemotherapy) received 177Lu-J591. A total of 10.6% experienced ≥50% decline in PSA, 36.2% experienced ≥30% decline, and 59.6% experienced any PSA decline following their single treatment. One of 12 with measurable disease experienced a partial radiographic response (8 with stable disease). Sites of prostate cancer metastases were targeted in 44 of 47 (93.6%) as determined by planar imaging. All experienced reversible hematologic toxicity, with grade 4 thrombocytopenia occurring in 46.8% (29.8% received platelet transfusions) without significant hemorrhage. A total of 25.5% experienced grade 4 neutropenia, with one episode of febrile neutropenia. The phase I maximum tolerated dose (70 mCi/m2) resulted in more 30% PSA declines (46.9% vs. 13.3%, P = 0.048) and longer survival (21.8 vs. 11.9 months, P = 0.03), but also more grade 4 hematologic toxicity and platelet transfusions. No serious nonhematologic toxicity occurred. Those with poor PSMA imaging were less likely to respond.

Conclusion: A single dose of 177Lu-J591 was well tolerated with reversible myelosuppression. Accurate tumor targeting and PSA responses were seen with evidence of dose response. Imaging biomarkers seem promising. Clin Cancer Res; 19(18); 5182–91. ©2013 AACR.
A Neu View of Invasive Lobular Breast Cancer
Authors: Bose Ron
Published: May 2013

Genome sequencing of relapsed, invasive lobular breast cancer identified actionable mutations in 86% of the cases. HER2 alterations occur in 27% of the cases, including 4 cases with activating HER2 mutations and 1 with a novel HER2–GRB7 gene fusion. This fusion links the HER2 tyrosine kinase domain to the GRB7 src homology 2 (SH2) domain. Clin Cancer Res; 19(13); 3331–3. ©2013 AACR.
Predicting Outcome by Images?
Authors: De Ruysscher Dirk
Published: May 2013

Features from CT, MRI, and PET scans are related to survival of patients with non–small cell lung carcinoma. Individualized image-based tissue characterization allows a whole body view of all tumor deposits and organs at risk. The time is ripe to embark on huge international studies aiming to validate and implement this technology in clinical practice. Clin Cancer Res; 19(13); 3334–6. ©2013 AACR.
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
Authors: Liu Yan , Marks Kevin , Cowley Glenn S. , Carretero Julian , Liu Qingsong , Nieland Thomas J.F. , Xu Chunxiao , Cohoon Travis J. , Gao Peng , Zhang Yong , Chen Zhao , Altabef Abigail B. , Tchaicha Jeremy H. , Wang Xiaoxu , Choe Sung , Driggers Edward M. , Zhang Jianming , Bailey Sean T. , Sharpless Norman E. , Hayes D. Neil , Patel Nirali M. , Janne Pasi A. , Bardeesy Nabeel , Engelman Jeffrey A. , Manning Brendan D. , Shaw Reuben J. , Asara John M. , Scully Ralph , Kimmelman Alec , Byers Lauren A. , Gibbons Don L. , Wistuba Ignacio I. , Heymach John V. , Kwiatkowski David J. , Kim William Y. , Kung Andrew L. , Gray Nathanael S. , Root David E. , Cantley Lewis C. , Wong Kwok-Kin
Published: May 2013

The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non–small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrative approach to define novel therapeutic targets in KRAS-driven LKB1-mutant lung cancers. High-throughput RNA interference screens in lung cancer cell lines from genetically engineered mouse models driven by activated KRAS with or without coincident Lkb1 deletion led to the identification of Dtymk, encoding deoxythymidylate kinase (DTYMK), which catalyzes dTTP biosynthesis, as synthetically lethal with Lkb1 deficiency in mouse and human lung cancer lines. Global metabolite profiling showed that Lkb1-null cells had a striking decrease in multiple nucleotide metabolites as compared with the Lkb1–wild-type cells. Thus, LKB1-mutant lung cancers have deficits in nucleotide metabolism that confer hypersensitivity to DTYMK inhibition, suggesting that DTYMK is a potential therapeutic target in this aggressive subset of tumors.

Significance: Using cell lines derived from the lung cancers occurring in genetically engineered mice, we conducted an integrative genome-wide short hairpin RNA and metabolite screen to identify DTYMK as a potential therapeutic target in Kras/Lkb1–mutant lung cancer. We believe that DTYMK is tractable for the development of novel therapeutics, and show an integrative approach to target identification that reduces false-positive candidates and should have broad applicability for the development of targeted therapeutics. Cancer Discov; 3(8); 870–9. ©2013 AACR.

See related commentary by Marcus and Khuri, p. 843

This article is highlighted in the In This Issue feature, p. 826
Validation of the Amsterdam IADL Questionnaire©, a New Tool to Measure Instrumental Activities of Daily Living in Dementia
Authors: Sikkes Sietske A.M. , Knol Dirk L. , Pijnenburg Yolande A.L. , de Lange-de Klerk Elly S.M. , Uitdehaag Bernard M.J. , Scheltens Philip
Published: May 2013

Background: This study describes the validation of a new instrument measuring instrumental activities of daily living (IADL), the Amsterdam IADL Questionnaire© (a registered copyright of the Alzheimer Center of the VU University Medical Center). This informant-based tool aimed at detecting IADL problems in incipient dementia was previously found to have a high internal consistency and test-retest reliability. Methods: Patients and their informants who visited the Alzheimer Center of the VU University Medical Center were included in this study. Item response theory was used to estimate the individuals' trait levels as a measure of IADL disability. Construct validity was tested by correlating estimated trait levels with clinical and demographic measures using Pearson's or Kendall's τ correlation coefficients. Additionally, estimated trait levels between patients with and without dementia and between patients with early- and late-onset dementia were compared using independent t tests. Results: A total of 206 informants of patients completed the Amsterdam IADL Questionnaire. The correlations between estimated trait levels and other measures were in concordance with previously formed hypotheses. Patients diagnosed with dementia (n = 93) had higher estimated trait levels than patients without dementia (n = 96), Cohen's effect size, d = 1.04, t(187) = 7.1, p < 0.001. We found no differences between early- and late-onset dementia patients. Conclusions: Results suggest that the Amsterdam IADL Questionnaire is a reliable and valid instrument in the evaluation of dementia.
The Impact of Prior TURP on Radical Prostatectomy Surgical Margins: A Multicenter Analysis
Authors: Gacci Mauro , Simonato Alchiede , Lanciotti Michele , Ennas Marco , Varca Virginia , Maffezzini Massimo , Imbimbo Ciro , Gontero Paolo , Schiavina Riccardo , Carini Marco , Martorana Giuseppe , Nicita Giulio , Mirone Vincenzo , Carmignani Giorgio ,   and members of the MIRROR Study, LUNA Foundation
Published: May 2013

Objective: To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). Materials and Methods: 2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively enrolled in 135 departments. We correlated PSM rates and all preoperative, surgical and pathological features. We stratified the site of PSM as unique or multifocal. Moreover, we analyzed differences between 75 patients who had undergone previous TURP and the remaining 2,333 patients. Results: In the entire study population, we identified 702 patients with PSM (29%). Using univariate analysis, we reported a significant correlation between overall PSM and prostate-specific antigen (PSA), stage cT, biopsy Gleason score, number of biopsy cores, number of positive cores, percentage of positive cores and nerve-sparing approach. PSM proved to be strongly dependent on pT in particular in patients with pT2 PCa. When we compared the data from 75 patients previously treated with TURP and those from 2,333 without previous prostatic surgery, a statistically significant difference in margin localization was found. Moreover, we analyzed the 75 patients mentioned above, stratified in incidental PCa diagnosed at TURP or PCa detected with prostate biopsy for PSA rising during the post-TURP follow-up: no statistical differences were found between the 2 groups regarding margin status, even if PSM were more frequent in incidental PCa with no significance deriving from the stratification for PSM location at the apex or base. Conclusion: Men treated with TURP before RP presented an overall incidence of PSM similar to those without previous TURP, but with a higher risk of PSM at the bladder neck and a lower risk of PSM at the prostatic apex.
Iron Status and Dietary Iron Intake of Vegetarian Children from Poland
Authors: Gorczyca Daiva , Prescha Anna , Szeremeta Karolina , Jankowski Adam
Published: May 2013

Background/Aim: In Poland, vegetarian diets are becoming more and more popular. The aim of this study was to examine the effect of iron intake on iron status in vegetarian children. Methods: Dietary iron intake, iron food sources, blood count, serum iron, ferritin level and total iron-binding capacity were estimated in two groups of children, namely vegetarians (n = 22) and omnivores (n = 18) of both sexes, aged from 2 to 18 years. Seven-day food records were used to assess their diet. Results: Dietary iron intake in vegetarians and omnivores was low (up to 65.0 and 60.1% of the recommended dietary allowance). A significantly higher intake of vitamin C was observed in vegetarians compared with omnivores (p = 0.019). The main sources of iron in vegetarians were cereal products, followed by vegetables and mushroom products, then fruit. The prevalence of iron deficiency (ID) was higher in the vegetarian group (p = 0.023). The serum ferritin level and mean corpuscular volume in the vegetarians were also lower than in the omnivores (p = 0.01 and p = 0.014, respectively). Conclusions: Children who follow a vegetarian diet may suffer from ID in spite of having a high vitamin C intake. This indicates the need to introduce dietary education and iron status monitoring.
Surgical RF Ablation of Atrial Fibrillation in Patients Undergoing Mitral Valve Repair for Barlow Disease
Authors: Rostagno Carlo , Droandi G. , Gelsomino S. , Carone E. , Gensini G.F. , Stefàno P.L.
Published: May 2013

Objectives: At present, limited experience exists on the treatment of atrial fibrillation (AF) in patients undergoing mitral valve repair (MVR) for Barlow disease. The aim of this investigation was to prospectively evaluate the radiofrequency ablation of AF in patients undergoing MVR for severe regurgitation due to Barlow disease. Methods: From January 1, 2007 to December 31, 2010, out of 85 consecutive patients with Barlow disease, 27 with AF underwent RF ablation associated with MVR. They were examined every 4 months in the first year after surgery and thereafter twice yearly. Results: At follow-up, AF was observed in 4/25 (16.0%). NYHA (New York Heart Association) functional class improved significantly, with no patients in class III or IV (before surgery, 81.5% had been). Otherwise, among 58 patients in sinus rhythm, 6 (11%) developed AF during follow-up. No clinical or echocardiographic predictive factor was found in this subgroup. Conclusions: Results from our investigation suggest that radiofrequency ablation of AF in patients with Barlow disease undergoing MVR for severe regurgitation is effective and should be considered in every patient with Barlow disease and AF undergoing valve surgical repair.
Fibroepithelioma of Pinkus: Case Reports and Review of the Literature
Authors: Reggiani Camilla , Zalaudek Iris , Piana Simonetta , Longo Caterina , Argenziano Giuseppe , Lallas Aimilios , Pellacani Giovanni , Moscarella Elvira
Published: May 2013

Fibroepithelioma of Pinkus (FeP) is an unusual form of basal cell carcinoma, which may clinically mimic a range of benign skin tumors that are not routinely excised. Preliminary observations on a total of 20 published cases of FeP suggest that dermoscopy and reflectance confocal microscopy may aid the clinical diagnosis and management of FeP. Herein we report the clinical, dermoscopic and confocal microscopic features of 3 additional cases of FeP, which were clinically misclassified as benign skin tumors, and discuss the role of dermoscopy and confocal microscopy in the clinical diagnosis of this condition.
Unrecognized Paraganglioma of the Urinary Bladder as a Cause for Basilar-Type Migraine
Authors: Pichler Renate , Heidegger Isabel , Klinglmair Gerald , Kroiss Alexander , Uprimny Christian , Gasser Rudolf Wolfgang , Schäfer Georg , Steiner Hannes
Published: May 2013

Extra-adrenal paraganglioma with isolated localization in the urinary bladder is a rare neuroendocrine tumor. Although the typical symptoms like headache, nausea, weight loss, flushing, heart palpitation or paroxysmal hypertension during micturition are well established, we present an unusual case of bladder paraganglioma, ‘misdiagnosed' with basilar-type migraine due to headache for the past 8 years. As urologists linked the presence of a tumor (by CT) and symptoms connected with micturition, no cystoscopy and no transurethral resection of the bladder was performed prior to detailed diagnostic workup. After diagnosis of an extra-adrenal paraganglioma, the patient was scheduled for open partial cystectomy. In consideration of the fact that bladder paraganglioma is an infrequent genitourinary cancer, this case report clearly points out the importance of an exact anamnesis and clinical examination to minimize the probability of misdiagnosis with possible fatal consequences in any case with clinical suspicion of bladder paraganglioma.
Management of Small and Intermediate Congenital Nevi: A Nationwide Survey in Italy
Authors: Stanganelli Ignazio , Ascierto Paolo , Bono Riccardo , De Giorgi Vincenzo , Pimpinelli Nicola , Chiarion-Sileni Vanna , Palmieri Giuseppe , Pizzichetta Maria Antonietta , Testori Alessandro
Published: May 2013

Objective: Small- and intermediate-sized congenital nevi (SCN and ICN) undergo periodic clinical monitoring or surgical excision. We analyzed the management of SCN and ICN in the Italian hospital network. Methods: A nationwide survey of a representative sample of centers was conducted. Data were analyzed grouping centers by melanoma incidence into high-volume (>25 diagnoses per year) and low-volume (≤25 diagnoses per year). Results: In the pediatric population, 11% of SCN and 22% of ICN are excised, the remainder undergoing clinical monitoring at intervals of 6 months to 2 years (SCN) and of 6 months to 1 year (ICN). In adults, 24% of SCN and 41% of ICN are excised. Clinical monitoring of SCN varies from 6-monthly (most common among low-volume hospitals) to every 2 years; preferred strategies for ICN are follow-up at 1 year (51%) or follow-up at 6 months (42%). For prophylactic surgery, complete excision is preferred. Conclusions: The Italian hospital network values management and treatment of SCN and ICN. In most cases natural evolution prompts prophylactic excision. Clinical examination is an important monitoring tool, though follow-up frequency depends on the clinician's experience and practice.
Impact of Mole Mapping in the Italian Health System
Authors: Stanganelli Ignazio , Ascierto Paolo , Bono Riccardo , De Giorgi Vincenzo , Pimpinelli Nicola , Chiarion-Sileni Vanna , Palmieri Giuseppe , Pizzichetta Maria Antonietta , Testori Alessandro
Published: May 2013

Objective: To analyze routine clinical management of atypical melanocytic lesions through monitoring or surgery in Italian hospitals. Methods: A nationwide survey of clinical practices was conducted. Results: Digital monitoring is performed in most Italian hospitals and is preferred over excision for single atypical melanocytic lesions in 82% of hospitals. For multiple atypical lesions, 60% of high-volume hospitals prefer digital monitoring to surgical excision (40%). There is a statistically significant difference between high- and low-volume hospitals (60 vs. 39%; p = 0.003). Digital monitoring is performed at mean intervals of 4/5 months for both types of lesions. Conclusions: We show an asymmetric relation between application of the method and practical impact based on available clinical evidence. Although digital monitoring provides better characterization of the evolution of melanocytic lesions, our results indicate that the advantages and limitations of this method require further investigation.
Second-Trimester Screening for Trisomy-21 Using Prefrontal Space Ratio
Authors: Chaveeva Petya , Agathokleous Maria , Poon Leona C.Y. , Markova Desislava , Nicolaides Kypros H.
Published: May 2013

Objective: To investigate the potential value of prefrontal space ratio (PFSR) in second-trimester screening for trisomy-21. Methods: A retrospective study utilizing stored midsagittal two-dimensional images of fetal profiles in 240 euploid and 45 trisomy-21 pregnancies at 16+0-23+6 weeks' gestation. The vertical distance between the leading edge of the skull and that of the skin (D1) and the distance between the skull and the mandibulo-maxillary line (D2) were measured and the D1:D2 ratio (PFSR) was calculated. In euploid pregnancies, regression analysis was used to determine the association between D1, D2 and PFSR with gestational age (GA). D1 and D2 were expressed as delta (Δ) values with gestational age. ΔD1, ΔD2 and PFSR in cases and controls were compared. Results: In trisomy-21, compared to controls, ΔD1 was increased (1.417 vs. 0.000 mm, p < 0.0001), ΔD2 was decreased (-0.842 vs. 0.000 mm, p = 0.003) and PFSR was increased (0.753 vs. 0.463, p < 0.0001). At a false-positive rate of 5%, the detection rates in screening by ΔD1, ΔD2 and PSFR were 80.0% (95% CI 65.4-90.4), 46.7% (95% CI 31.7-62.1) and 100.0% (95% CI 92.1-100.0), respectively. Conclusion: The PFSR is an effective marker in second-trimester screening for trisomy-21.
Subendocardial Viability Ratio Predicts Cardiovascular Mortality in Chronic Kidney Disease Patients
Authors: Di Micco L. , Salvi P. , Bellasi A. , Sirico M.L. , Di Iorio B.
Published: May 2013

Background: The subendocardial viability ratio (SEVR), calculated by pulse wave analysis, is an index of myocardial oxygen supply and demand. Here we analyze the relation between SEVR and cardiovascular mortality in the chronic kidney disease (CKD) population of a post hoc analysis of a multicenter, prospective, randomized, nonblinded study. Methods: We studied 212 consecutive asymptomatic outpatients receiving care at 12 nephrology clinics in south Italy. Inclusion criteria were age >18 years, 6 months of follow-up before the enrollment and stage 3-4 CKD. Results: During follow-up, 34 subjects died, 29 of them for cardiovascular causes. SEVR correlated inversely with vascular calcifications (r = -0.37) and myocardial mass (r = -0.45); SEVR changed from 1.33 ± 0.24 to 1.36 ± 0.16 (p = NS; baseline and final values, respectively) in living patients, and from 1.16 ± 0.31 to 0.68 ± 0.26 in deceased patients (p < 0.001). Kaplan-Meier curves show that that a greater reduction of SEVR values during the study (third tertile) significantly predicts cardiovascular mortality (p < 0.0001). Conclusions: This post hoc analysis shows that a reduction of SEVR values impacts cardiovascular mortality in CKD patients.
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke
Authors: Rocco Andrea , Heuschmann Peter U. , Schellinger Peter D. , Köhrmann Martin , Diedler Jennifer , Sykora Marek , Nolte Christian H. , Ringleb Peter , Hacke Werner , Jüttler Eric
Published: May 2013

Background and Purpose—

Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA
1c
) on sICH.

Methods—

In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose was obtained at admission. HbA
1c
was determined within hospital stay. A second head computed tomography was obtained after 24 hours or when neurological worsening occurred. Modified Rankin Scale was used to assess outcome at 90 days.

Results—

A total of 222 patients (19.9%) had any hemorrhage; 43 of those had sICH (3.9%) per Safe Implementation of Treatments in Stroke definition and 95 (8.5%) per National Institute of Neurological Disorders and Stroke definition; 33.2% of patients had a dependent outcome (modified Rankin Scale score 3–5). In univariate analysis history of diabetes mellitus, HbA
1c
, blood glucose, and National Institute of Health Stroke Scale score on admission were associated with any hemorrhage and sICH. In multivariate analysis National Institute of Health Stroke Scale score, a history of diabetes mellitus, and HbA
1c
were predictors of sICH per National Institute of Neurological Disorders and Stroke, and only HbA
1c
when Safe Implementation of Treatments in Stroke criteria were used.

Conclusions—

In our study, HbA
1c
turns out to be an important predictor of sICH after thrombolysis for acute stroke. These results suggest that hemorrhage after thrombolysis may be a consequence of long-term vascular injury rather than of acute hyperglycemia, and that HbA
1c
may be a better predictor than acute blood glucose or a history of diabetes mellitus.
Analysis of the Costs and Payments of a Coordinated Stroke Center and Regional Stroke Network
Authors: Rymer Marilyn M. , Armstrong Edward P. , Meredith Neil R. , Pham Sissi V. , Thorpe Kevin , Kruzikas Denise T.
Published: May 2013

Background and Purpose—

An earlier study demonstrated significantly improved access, treatment, and outcomes after the implementation of a progressive, comprehensive stroke program at a tertiary care community hospital, Saint Luke’s Neuroscience Institute (SLNI). This study evaluated the costs associated with implementing such a program.

Methods—

Retrospective analysis of total hospital costs and payments for treating patients with ischemic stroke at SLNI (n=1570) as program enhancement evolved over time (2005, 2007, and 2010) and compared with published national estimates. Analyses were stratified by patient demographic characteristics, patient outcomes, treatments, time, and comorbidities.

Results—

Controlling for inflation, there was no difference in SLNI total costs between 2005 and either 2007 or 2010, suggesting that while SLNI provided an increased level of services, any additional expenditures were offset by efficiencies. SLNI total costs were slightly lower than published benchmarks. Consistent with previous stroke care cost estimates, the median overall differential between total hospital costs and payments for all ischemic stroke cases was negative.

Conclusions—

SLNI total costs remained consistent over time and were slightly lower than previously published estimates, suggesting that a focused, streamlined stroke program can be implemented without a significant economic impact. This finding further demonstrates that providing comprehensive stroke care with improved access and treatment may be financially feasible for other hospitals.
Eritrean Pentecostals as Asylum Seekers in Britain
Authors: Anderson Allan Heaton
Published: May 2013

Abstract

This article explores the background and issues relating to the plight of Eritrean Pentecostal asylum seekers, and is based on background literature on the Eritrean context and interviews with Eritrean asylum seekers in the UK. It explores the historical, political, and religious context of Eritrea and analyses the challenges presented to British immigration officials by the presence of Eritrean asylum seekers who claim to be persecuted for their Pentecostal faith. The article examines the processes from the perspective of personal narratives of asylum seekers, their reasons for fleeing their country, the documents and statements used to deny them asylum in the application process, and the characteristics of their faith that are often overlooked.
Faith Tabernacle Congregation and the Emergence of Pentecostalism in Colonial Nigeria, 1910s-1941
Authors: Mohr Adam
Published: May 2013

Abstract

Faith Tabernacle literature first spread into the Christian community in Lagos from Western Ghana in the 1910s. By at least 1917 Faith Tabernacle literature was being read in Lagos, and the first formal branch was established in Lagos in 1920. During the early 1920s Faith Tabernacle literature was being spread throughout Nigeria as Faith Tabernacle members traveled across the colony as labor migrants, leading to the rapid spread of the church, particularly in the major cities. By early 1929 Faith Tabernacle had established 61 branches in Nigeria with over 1,200 members. However, due to the schisms of 1925 and 1929, many Faith Tabernacle leaders, members, communicants, and entire congregations left the church to establish the first Pentecostal denominations in Nigeria, which were the Apostolic Faith (1928), the Apostolic Church (1931), the Assemblies of God (1939), and the Christ Apostolic Church (1941).
Eugenia pipensis, a new species of Eugenia sect. Umbellatae (Myrtaceae) from northeastern Brazil
Authors: LIMA LOURENÇO ANA RAQUEL
Published: May 2013

A new species of Eugenia from the Atlantic rainforest of Rio Grande do Norte is described as Eugenia pipensis. The species is close to E. astringens, but differs by having calyx lobes 2.5 to 3 mm long and glandulose-verruculose fruits.
A new species of Passiflora subgenus Passiflora series Quadrangulares (Passifloraceae) from the Brazilian Amazon
Authors: KOCH ANA KELLY , CARDOSO ANDRÉ LUIZ DE REZENDE , ILKIU-BORGES ANNA LUIZA
Published: May 2013

A new species of Passiflora is described from reforested post bauxite-mined area in the National Forest of Saracá- Taquera in the Brazilian state of Pará. The species is illustrated and its affinities with related species are discussed, and a key to the species of supersection Laurifoliae, series Quadrangulares is presented. The series Quadrangulares is composed of four species that constitute a small complex of large-flowered and large-fruited passionflowers with 3–4- angulate-winged stems that occurs naturally in the moist lowlands from Nicaragua to Brazil and French Guiana. However, among the four species of the series, Passiflora trialata is closely related to the new species by the 3-angular stems, the color and shape of sepals and petals, the 3-angular petioles and peduncles, and the single operculum.
A new species of Antherostele (Urophylleae, Rubioideae, Rubiaceae) from Mt. Sohoton, Samar, Philippines
Authors: OBICO JASPER JOHN A. , ALEJANDRO GRECEBIO JONATHAN D.
Published: May 2013

Antherostele samarensis, a new species from Mt. Sohoton, Samar, Philippines, is here described and illustrated. This seemingly rare species is the second record of Antherostele in the locality. It is characterized by the non-canaliculate petioles, small triangular stipules, colleters distributed throughout the adaxial side of the stipules, small calyces, and strongly reflexed corolla lobes. The affinity among the new species and the other species of the genus is also discussed.
A new species of Neocypholaelaps Vitzthum (Acari: Ameroseiidae), with notes on the cheliceral lobes and ventral pore-like structures of mites of this family
Authors: NARITA JOÃO PAULO Z. , PÉDELABAT MARIE , DE MORAES GILBERTO J.
Published: May 2013

Neocypholaelaps kreiteri n. sp. is described based on the morphology of adult females, males, deutonymphs, protonymphs and larvae collected on inflorescences of Cocos nucifera L. (Arecaceae) in La Réunion Island, Indian Ocean. This is the first species of Neocypholaelaps reported from that island. It is most similar to N. cocos Evans, 1963 and N. stridulans Evans, 1955. A discussion is presented about the presence of cheliceral lobes and the absence of pilus dentilis on the fixed cheliceral digit of ameroseiid species, relating that to what has been reported for the Melicharidae and the Phytoseiidae. A discussion is also presented about the identity of a pore-like structure positioned anteriad of the genital lyrifissures (iv5) in many ameroseiids. These are interpreted as being a pore that in many ameroseiids and in other Gamasina are often in-distinctly and located close to the posteromesad margin of coxae IV, on the posterior end of the exopodal shield.
A new species of the genus Pleuroxus Baird (Cladocera: Anomopoda: Chydoridae) from Jeju Island, South Korea
Authors: JEONG HYUN GI , KOTOV ALEXEY A. , LEE WONCHOEL
Published: May 2013

A new species of the genus Pleuroxus Baird (Cladocera: Anomopoda: Chydoridae) is described from Jeju Island, South Korea. P. jejuensis sp. nov. is the closest relative of the aduncus-like species from southern hemisphere instead of P. aduncus s. str. It shares with P. wittsteini Studer, 1878 in: (1) brown colour; (2) absence of denticles on postero-ventral portion of valve; (3) unusually short postpore distance; (4) grouped postanal teeth. P. jejuensis sp. nov. differs from P. wittsteini in: (1) smaller postpore distance; (2) submarginal setules on inner side of the posterior valve margin; (3) prominent postero-dorsal angle of the postabdomen; (4) only two postanal teeth in each group; (5) longer proximalmost basal spine of the postabdominal claw; (6) very short accessory seta on limb I. The wittsteini-like chydorines seem to be remnants of an old, pan-continental species group.
Molecular and morphological characterization of two avian malaria parasites (Haemosporida: Plasmodiidae), with description of Plasmodium homonucleophilum n. sp.
Authors: ILGŪNAS MIKAS , PALINAUSKAS VAIDAS , IEZHOVA TATJANA A. , VALKIŪNAS GEDIMINAS
Published: May 2013

Plasmodium homonucleophilum n. sp. was described from the Common Grasshopper Warbler Locustella naevia based on the morphology of blood stages and partial sequences of the mitochondrial cytochrome b (cyt b) gene. This malaria para-site belongs to the subgenus Novyella; it can be readily distinguished from all described Novyella parasites due to two features, i. e. the strict adherence of its meronts to the nuclei of infected erythrocytes and the lack of such adherence in the case of gametocytes. We also found the lineage pLZFUS01 in Red-Backed Shrike Lanius collurio, identified this parasite and conclude that it belongs to Plasmodium relictum. Illustrations of blood stages of these two parasites are given. DNA lineages associated with P. homonucleophilum (pSW2, GenBank KC342643) and P. relictum (pLZFUS01, GenBank KC342644) are reported and can be used for molecular identification of these malarial infections. Phyloge-netic analysis determines DNA lineages closely related to both reported parasites and is in accordance with the para-sites’ morphological identification. This study contributes to barcoding of avian malaria parasites using partial sequences of cyt b gene.
Contribution to the study of arrenuroid water mites (Acari: Hydrachnidia) from Turkey
Authors: ESEN YUNUS , ERMAN ORHAN , DILKARAOGLU SIBEL
Published: May 2013

In this paper, one new water mite species of the genus Arrenurus, i.e. Arrenurus (s.str.) ovatipetiolatus Esen & Erman sp. nov. and some new records for the Turkish fauna are given. The first description of the female of Arrenurus (s.str.) anta-lyensis Gülle, Boyacı & Gülle, 2011 is given. Arrenurus (s.str.) kermanensis Pešić, Smit & Asadi, 2011, which is only known from type locality in Iran, and reported here, is new record for the Turkish fauna, is redescribed. Arrenurus (s.str.) kurui Erman, 1993 is considered a junior synonym of Arrenurus (s.str.) vavrai Thon, 1899. Krendowskia (s.str.) levanten-sis Smit, 1997, a species only known from Israel and Iran, is reported first time from Turkey.
New fossil taxa and notes on the Mesozoic evolution of Liadytidae and Dytiscidae (Coleoptera)
Authors: PROKIN ALEXANDER A. , PETROV PYOTR N. , WANG BO , PONOMARENKO ALEXANDER G.
Published: May 2013

The diagnoses of Liadytidae Ponomarenko, 1977, Liadytiscinae Prokin & Ren, 2010, Liadytiscus Prokin & Ren, 2010 and Mesoderus Prokin & Ren, 2010 (Dytiscidae) are modified, and the following new taxa are described from Mesozoic fossils: Liadytes aspidytoides sp. n. (Liadytidae); Mesoderini trib. n., Liadyxianus kirejtshuki gen. n. et sp. n., Mesoderus punctatus sp. n., Mesoderus ovatus sp. n., Mesodytes rhantoides gen. n. et sp. n., Palaeodytes baissiensis sp. n. and Cretodytes incertus sp. n. (Dytiscidae). A summarized checklist of all Mesozoic Liadytidae and Dytiscidae known from adults is given, and an identification key to the genera of Mesozoic Dytiscidae known from adults is provided for the first time. Palaeodytes incompletus Ponomarenko, Coram & Jarzembowski, 2005 (the suffix of the specific epithet is emended from the original incompleta) is found to belong not to this genus, but to another one, which remains to be described. The fossil larva Angaragabus jurassicus Ponomarenko, 1963 from the Lower Jurassic of Irkutsk Oblast, Russia, probably belonging to Liadytidae, is re-examined. If this larva actually belongs to Liadytidae, then its morphological characters provide additional confirmation of the conclusion, based on the characters of adult liadytids, that the family is quite separate from the recent family Aspidytidae, and the similarity between the adults of both families results from parallel processes in the evolution of the superfamily Dytiscoidea. We show that the principal trends of morphological changes of Liadytidae and Dytiscidae during the Upper Jurassic and Lower Cretaceous included a consistent increase in the area of the metacoxal plates at the expense of decreasing area of the lateral lobes of the metaventrite ("wings"), flattening and loss of the lateral border of the elevated median area of the metaventrite, and shortening and dilation of the metafemur and metatibia. These changes were probably associated with an increased load of swimming taken by the hindlegs, which required, among other things, the development of swimming muscles attached to the metacoxal plates. The development of the hindlegs allowed diving deeper, thus being an adaptation to the nektonic instead of benthic lifestyle. This is confirmed by the adaptive coloration of the Liadytidae and Dytiscidae found in Shar Teg (Liadytes aspidytoides sp. n.), Yixian (Mesoderus magnus Prokin & Ren, 2010) and Baisa (Palaeodytes baissiensis sp. n.), in which the dorsum was darker than underside, providing camouflage in the depths of the water.
Identification, distribution, and adult phenology of the carrion beetles (Coleoptera: Silphidae) of Texas
Authors: MULLINS PATRICIA L. , RILEY EDWARD G. , OSWALD JOHN D.
Published: May 2013

The carrion beetles (Coleoptera: Silphidae) of Texas are surveyed. Thirteen of the 14 species, and five of the six genera, of this ecologically and forensically important group of scavengers that have previously been reported from Texas are confirmed here based on a study of 3,732 adult specimens. The one reported, but unconfirmed, species, Oxelytrum discicolle, was probably based on erroneous label data and is excluded from the Texas fauna. Two additional species, Nicrophorus sayi and N. investigator are discussed as possible, but unconfirmed, components of the fauna. Taxonomic diagnoses, Texas distribution range maps, seasonality profiles, and biological notes are presented for each confirmed species. The confirmed Texas silphid fauna of 13 species comprises 43% of the 30 species of this family that are known from America north of Mexico. The highest richness (11 species) is found in the combined Austroriparian and Texan biotic provinces of eastern Texas. Phenologically, three species (Necrophila americana, O. rugulosum and Nicrophorus tomentosus) exhibit bimodal adult temporal occurrence patterns with peaks in the spring and late summer or fall; four species (Oiceoptoma noveboracense, Necrodes surinamensis, Nicrophorus carolinus, and N. orbicollis) exhibit unimodal occurrence patterns with a single peak in late spring or early summer; one species (Oiceoptoma inaequale) exhibits a unimodal occurrence pattern with a single peak in early spring; and five species (Thanatophilus truncatus, Nicrophorus americanus, N. marginatus, N. mexicanus and N. pustulatus) display unimodal occurrence patterns with peaks in late summer or early fall.
Revision of the Afrotropical Lycorininae (Ichneumonidae; Hymenoptera) with description of a new species from South Africa
Authors: ROUSSE PASCAL , NOORT SIMON VAN
Published: May 2013

We revise the Afrotropical Lycorininae and describe Lycorina yui Rousse & van Noort sp. nov. from South Africa. An illustrated key to Lycorininae species of the Afrotropical region is provided. Lycorina continentalis (Benoit, 1953) is con-sidered a junior synonym of Lycorina fici Seyrig, 1932, and is newly reported from Uganda and South Africa. Online di-chotomous and interactive Lucid keys are available at http://www.waspweb.org.
A Revised Conceptual Model of the Tropical Marine Boundary Layer. Part I: Statistical Characterization of the Variability Inherent in the Wintertime Trade Wind Regime over the Western Tropical Atlantic
Authors: Davison Jennifer L. , Rauber Robert M. , Di Girolamo Larry , LeMone Margaret A.
Published: May 2013

This paper investigates wintertime tropical marine boundary layer (TMBL) statistical characteristics over the western North Atlantic using the complete set of island-launched soundings from the Rain in Cumulus over the Ocean (RICO) experiment. The soundings are subdivided into undisturbed and disturbed classifications using two discriminators: 1) dates chosen by Global Energy and Water Cycle Experiment (GEWEX) Cloud System Studies (GCSS) investigators to construct the mean RICO sounding and 2) daily average rain rates.

A wide range of relative humidity (RH) values was observed between the surface and 8.0 km. At 2.0 km, half the RH values were within 56%–89%; at 4.0 km, half were within 13%–61%. The rain-rate method of separating disturbed and undisturbed soundings appears more meaningful than the GCSS method. The median RH for disturbed conditions using the rain-rate method showed moister conditions from the surface to 8.0 km, with maximum RH differences of 30%–40%. Moist air generally extended higher on disturbed than undisturbed days.

Based on equivalent potential temperature, wind direction, and RH analyses, the most common altitude marking the TMBL top was about 4.0 km. Temperature inversions (over both 50- and 350-m intervals) were observed at every altitude above 1.2 km; there were no dominant inversion heights and most of the inversions were weak. Wind direction analyses indicated that winds within the TMBL originated from more tropical latitudes on disturbed days.

The analyses herein suggest that the RICO profile used to initialize many model simulations of this environment represents only a small subset of the broad range of possible conditions characterizing the wintertime trades.
The rebirth of Catholic collective action in Central America: A new model of church-based political participation
Authors: Keogh Stacy , Wood Richard L
Published: May 2013

We analyze a new effort at collective political mobilization, sponsored by the Catholic Church in Central America following the demobilization of church-linked liberationist movements since the early 1990s. The current effort strives to re-project social Catholicism into the public arena by drawing on traditional Catholic structures, the cultural legacy of liberationist Catholicism, and a model of democratic organizing promoted by the PICO National Network in the United States. Drawing primarily on ethnographic and interview data, we explain the initial success of the effort in the light of the literature on resource mobilization, mobilizing structures, and the cultural dynamics of social movements, then assess the ongoing and future challenges that PICO-Central America is likely to face. We argue that despite PICO’s challenges in Central America, the movement represents a rebirth of Catholic activism in the region and holds significant promise as one element in the consolidation of democratic politics in Central America.
Introductory Psychology Textbooks
Authors: Griggs Richard A. , Jackson Sherri L.
Published: May 2013

It has been 13 years since the last objective analysis of full-length introductory psychology textbooks was published and 15 years since the textbook copyright period used in that study, 1995–1997. Given the importance of informed textbook evaluation and selection to the introductory course but the difficulty of this task because of the large number of texts available, it is important to provide teachers with as much information about introductory texts as possible. Thus, to aid teachers in this arduous task, we objectively analyzed the most current editions of the 13 full-length introductory texts published since 1997. Our analyses also allowed us to objectively compare introductory texts from the 1990s with those from the 2000s.
Peripherally Inserted Central Catheter (PICC) Complications During Pregnancy
Authors: Cape Alison V. , Mogensen Kris M. , Robinson Malcolm K. , Carusi Daniela A.
Published: May 2013

Background: Peripherally inserted central catheters (PICCs) are routinely used in women with hyperemesis gravidarum. However, little is known about the consequences of PICC insertion in these patients. Our aim was to analyze PICC‐related complication rates among pregnant women. Materials and Methods: Pregnant women with PICC insertion between January 2000 and June 2006 were studied retrospectively. Infusate type, comorbid conditions, and PICC duration were characterized. Major complications, defined as need for surgical intervention, bacteremia requiring intravenous antibiotics, or thromboembolic events, were identified. Minor complications, including phlebitis, PICC malfunction, early PICC removal, infection requiring oral antibiotics, or hospitalization for PICC evaluation, were also studied. Results: Eighty‐four catheters in 66 women were eligible for study, totaling 2544 PICC days. Catheters remained in place for 1–177 days; median duration was 21.0 days. PICCs were used for intravenous fluid (IVF, 59.4%), parenteral nutrition (PN, 34.5%), and antibiotics (6%). The overall complication rate was 18.5 per 1000 PICC days (55.9% of PICCs); 22.6% were major, with bacteremia being most frequent (20.2%). A diagnosis of diabetes was the only factor that significantly predicted complications (hazard ratio, 2.71; 95% confidence interval, 1.13–6.13). PICC duration and type of infusate (PN vs IVF alone) were not associated with complications. Conclusions: PICC insertion in pregnant women is associated with a high complication rate, which appears to be independent of the type of infusate and occurs in the majority of women. PICCs should be used judiciously and only when clearly necessary during pregnancy. Further studies are needed to determine how to reduce PICC‐related complications in this population.
Localized Tongue Amyloidosis: A Single Institutional Case Series
Authors: O'Reilly Ashley , D'Souza Anita , Lust John , Price Daniel
Published: May 2013

Objective

Review Mayo Clinic experience of localized tongue amyloidosis.

Study Design

Case series with retrospective chart review.

Setting

Academic medical center.

Subjects and Methods

Cases of localized tongue amyloidosis were identified from the dysproteinemia database at the Mayo Clinic in Rochester, Minnesota. Electronic records were reviewed with focus on presenting symptoms, laboratory results (ie, serum or urine immunoelectrophoresis, bone marrow biopsy, and fat aspirate analysis), treatment modality, and status of disease at follow‐up.

Results

Six cases of localized tongue amyloidosis presented to the Mayo Clinic between 1969 and 2011. Mean patient age was 69 years (range, 43‐90). Patients presented with asymptomatic tongue mass(es). Biopsy of the tongue mass in all patients showed amyloid on Congo red stains. Work‐up for systemic amyloidosis, including bone marrow biopsy, fat aspiration, and serum and urine protein immunoelectrophoresis, was negative for all 6 patients, nor was there other organ involvement. Two patients underwent resection of the lesions, and the remaining patients elected for observation. Recurrence requiring repeat excision occurred in 1 of the patients that underwent resection. Repeat evaluation for systemic involvement was performed in 3 patients 1 to 3 years after the initial diagnosis. None of these patients went on to develop systemic involvement.

Conclusions

Localized tongue amyloidosis remains a rare diagnosis and requires exclusion of systemic involvement. Localized lesions may be observed or resected; however, recurrence may occur with resection. Patients with localized tongue amyloidosis do not appear to be at increased risk of developing systemic involvement.