bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures S1-S8 from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients
Authors: González-Vallinas Margarita , Rodríguez-Paredes Manuel , Albrecht Marco , Sticht Carsten , Stichel Damian , Gutekunst Julian , Pitea Adriana , Sass Steffen , Sánchez-Rivera Francisco J. , Lorenzo-Bermejo Justo , Schmitt Jennifer , De La Torre Carolina , Warth Arne , Theis Fabian J. , Müller Nikola S. , Gretz Norbert , Muley Thomas , Meister Michael , Tschaharganeh Darjus F. , Schirmacher Peter , Matthäus Franziska , Breuhahn Kai
Published: April 2023

Figure S1. Expression of 14q32 miRNAs in tumor samples from lung adenocarcinoma patients according to EGFR, KRAS and TP53 mutation status. Figure S2. Methylation analysis of imprinting control regions of the 14q32 cluster in lung adenocarcinoma patients. Figure S3. Association of disease-free survival and N stage in never-smoker lung adenocarcinoma patients. Figure S4. Cell viability of lung adenocarcinoma cells after increasing 14q32 miRNA levels by CRISPR activation technology. Figure S5. Differential expression of genes adjacent to the 14q32 miRNA cluster activated by CRISPR activation technology. Figure S6. Association of genes modulated by 14q32 miRNAs with disease-free survival in lung adenocarcinoma patients. Figure S7. Cell viability of lung adenocarcinoma cells after increasing levels of 14q32 miRNAs by transfection of specific miRNA mimics. Figure S8. Validation of the migratory and invasive effects of miR-323b, miR-487a, and miR-539 on lung adenocarcinoma cells with different genetic background.
Supplementary Figure 1 from The Invasion Inhibitor Sarasinoside A1 Reverses Mesenchymal Tumor Transformation in an E-Cadherin–Independent Manner
Authors: Austin Pamela , Freeman Spencer A. , Gray Christopher A. , Gold Michael R. , Vogl A. Wayne , Andersen Raymond J. , Roberge Michel , Roskelley Calvin D.
Published: April 2023

PDF file - 391K, Supplemental data demonstrating sarasinoside A1's effects on proliferation and cell viability
Supplementary Data - Materials and Methods from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients
Authors: González-Vallinas Margarita , Rodríguez-Paredes Manuel , Albrecht Marco , Sticht Carsten , Stichel Damian , Gutekunst Julian , Pitea Adriana , Sass Steffen , Sánchez-Rivera Francisco J. , Lorenzo-Bermejo Justo , Schmitt Jennifer , De La Torre Carolina , Warth Arne , Theis Fabian J. , Müller Nikola S. , Gretz Norbert , Muley Thomas , Meister Michael , Tschaharganeh Darjus F. , Schirmacher Peter , Matthäus Franziska , Breuhahn Kai
Published: April 2023

Supplementary Data - Materials and Methods
Supplementary Figures 1-5, Supplementary Tables 1-5, Materials and Methods from Gut-derived Endotoxin-TLR4 Signaling Drives MYC-Ig Translocation to Promote Lymphoproliferation through c-JUN and STAT3 Activation
Authors: Rokan Ahmed , Hernandez Juan Carlos , Nitiyanandan Rajeshwar , Lin Zi-Ying , Chen Chia-Lin , Machida Tatsuya , Li Meng , Khanuja Jasleen , Chen Mo Li , Tahara Stanley M. , Siddiqi Imran , Machida Keigo
Published: April 2023

S1. Epigenetic and transcriptional landscape of AICDA (AID) regulatory region in HepG2 cells.
S2. Epigenetic and transcriptional landscape of FAS (CD95) regulatory region in many lymphoma and HCC cell lines.
S3. TLR4 expression in Oncomine database (Compagno lymphoma).
S4. Different human lymphoma gene profiles show high c-JUN, c-MYC, and TLR4.
S5. c-Jun disruption in mice prompted lymphoproliferation and skin diseases that were ameliorated by STAT3 inhibition.
Table S1. Resource table.
Table S2. Oncomine dataset: Basso Lymphoma
Table S3. DLBC Lymphoma Clinicopathological table
Table S4. Clinicopathological Table
Table S5. Transcription factor binding site sequences of mouse AID promoter
Supplemental Materials and Methods
Supplemental Figure 2 from Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane–Induced Death by AS101 via Inhibition of the VLA-4–IL10–Survivin Axis
Authors: Danoch Hila , Kalechman Yona , Albeck Michael , Longo Dan L. , Sredni Benjamin
Published: April 2023

Supplemental Figure S2. AS101 sensitizes breast carcinoma MCF-7 cells to Abraxane-induced death.
Supplemental Figure 1 from Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane–Induced Death by AS101 via Inhibition of the VLA-4–IL10–Survivin Axis
Authors: Danoch Hila , Kalechman Yona , Albeck Michael , Longo Dan L. , Sredni Benjamin
Published: April 2023

Supplemental Figure S1: AS101 induces Abraxane-induced cell death in B and T lymphoma cells.
Supplementary Figure Legend from Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling
Authors: Tabusa Hana , Brooks Teresa , Massey Andrew J.
Published: April 2023

PDF file - 58K
Supplemental material from The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53
Authors: Menendez Daniel , Nguyen Thuy-Ai , Snipe Joyce , Resnick Michael A.
Published: April 2023

Supplemental material and methods, supplemental tables (1-6) and supplemental figures (1-5)
Supplementary Table 1 from MYC-Induced Epigenetic Activation of GATA4 in Lung Adenocarcinoma
Authors: Castro Inês C. , Breiling Achim , Luetkenhaus Katharina , Ceteci Fatih , Hausmann Simone , Kress Sebastian , Lyko Frank , Rudel Thomas , Rapp Ulf R.
Published: April 2023

PDF file - 68K, Statistical significance of methylation percentage differences at GATA4 promoter of GATA4 positive and negative lung tumors and GATA4 positive liver metastasis tissues.
Supplemental Table 1 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers
Authors: Kastrati Irida , Joosten Stacey E. P. , Semina Svetlana E. , Alejo Luis H. , Brovkovych Svitlana D. , Stender Joshua D. , Horlings Hugo M. , Kok Marleen , Alarid Elaine T. , Greene Geoffrey L. , Linn Sabine C. , Zwart Wilbert , Frasor Jonna
Published: April 2023

Supplemental Table 1. Patient characteristics.
Supplemental Materials and Methods and Figure Legends from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers
Authors: Kastrati Irida , Joosten Stacey E. P. , Semina Svetlana E. , Alejo Luis H. , Brovkovych Svitlana D. , Stender Joshua D. , Horlings Hugo M. , Kok Marleen , Alarid Elaine T. , Greene Geoffrey L. , Linn Sabine C. , Zwart Wilbert , Frasor Jonna
Published: April 2023

Supplemental Materials and Methods and Figure Legends
Supplementary Dataset 1 from Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome
Authors: Svilar David , Dyavaiah Madhu , Brown Ashley R. , Tang Jiang-bo , Li Jianfeng , McDonald Peter R. , Shun Tong Ying , Braganza Andrea , Wang Xiao-hong , Maniar Salony , Croix Claudette M. St , Lazo John S. , Pollack Ian F. , Begley Thomas J. , Sobol Robert W.
Published: April 2023

XLS file - 1MB, Genes of interest from the siRNA screen that satisfied both selection criteria: a p-value less than 0.05 and a viability ratio in the lowest 5%
Supplementary Table 4 from Identification of Genomic Targets of Transcription Factor Aebp1 and its role in Survival of Glioma Cells
Authors: Ladha Jayashree , Sinha Swati , Bhat Vasudeva , Donakonda Sainitin , Rao Satyanarayana M.R.
Published: April 2023

PDF file - 157K, Motifs enriched upon analysis of random sequence
Supplementary Movie 2A from Constitutive K-RasG12D Activation of ERK2 Specifically Regulates 3D Invasion of Human Pancreatic Cancer Cells via MMP-1
Authors: Botta Gregory P. , Reginato Mauricio J. , Reichert Maximilian , Rustgi Anil K. , Lelkes Peter I.
Published: April 2023

AVI file - 8MB, Real-time imaging of E6/E7/Ras PDECs in 3D extending invadapodial protrusions and moving along the ECM over 30 m.
Supplementary Movie 1A from Constitutive K-RasG12D Activation of ERK2 Specifically Regulates 3D Invasion of Human Pancreatic Cancer Cells via MMP-1
Authors: Botta Gregory P. , Reginato Mauricio J. , Reichert Maximilian , Rustgi Anil K. , Lelkes Peter I.
Published: April 2023

AVI file - 30MB, Real-time imaging of invadapodial extensions into the ECM by E6/E7/Ras PDECs over 30 m.
Supplementary Figure 1 from Microenvironmental Regulation of BRCA1 Gene Expression by c-Jun and Fra2 in Premalignant Human Ovarian Surface Epithelial Cells
Authors: Zhou Lixin , Graves Marcia , MacDonald Gwen , Cipollone Jane , Mueller Christopher R. , Roskelley Calvin D.
Published: April 2023

PDF file - 525K, A dominant-negative AP1 effector decreases BRCA1 promoter activity in monolayer culture.
Supplementary Figures 1-8 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
Authors: Stern Josh Lewis , Hibshman Grace , Hu Kevin , Ferrara Sarah E. , Costello James C. , Kim William , Tamayo Pablo , Cech Thomas R. , Huang Franklin W.
Published: April 2023

Fig. S1. Projecting the individual TERTp mutations transcriptional signatures on top of the Onco-GPS map of cellular states (Kim et al. 2017). Fig.S2. Association between the different mRNA signatures analyzed in this study. Fig S3. Expression of epithelial and mesenchymal markers in TERTp mutants (TPM) and wild-type (wt) cancer cell lines. Fig S4. CDH1 expression levels in CCLE lines. Fig S5. GABPa and GABPb1 expression by tissue type. Fig S6. Stratification of TERTp mutant cell lines in The Cancer Therapeutics Response Portal (CTRP) by BRAF status reveals inhibition of growth in the absence of BRAF mutation. Fig. S7. Representative immunoblots of TERT promoter cell lines treated with trametinib for 24 hours.
Supplementary Figures 1-11 from The NSD2 p.E1099K Mutation Is Enriched at Relapse and Confers Drug Resistance in a Cell Context–Dependent Manner in Pediatric Acute Lymphoblastic Leukemia
Authors: Pierro Joanna , Saliba Jason , Narang Sonali , Sethia Gunjan , Saint Fleur-Lominy Shella , Chowdhury Ashfiyah , Qualls Anita , Fay Hannah , Kilberg Harrison L. , Moriyama Takaya , Fuller Tori J. , Teachey David T. , Schmiegelow Kjeld , Yang Jun J. , Loh Mignon L. , Brown Patrick A. , Zhang Jinghui , Ma Xiaotu , Tsirigos Aristotelis , Evensen Nikki A. , Carroll William L.
Published: April 2023

S1. Schematic diagram of NSD2 isoform indicating domains, the location of amino acid E1099 within the SET domain, and the targets of the shRNAs. S2. NSD2 Overexpression in B-ALL Cell Lines Does Not Impart Clonal Advantage. S3. Overexpression of REIIBP in B-ALL Cell Lines Does Not Impart Clonal Advantage. S4. Knockdown of WT NSD2 in B-ALL Cell Lines Does Not Lead to Phenotypic Differences. S5. Knockdown of NSD2 in RS4;11 and RCH-ACV lines leads to increased chemosensitivity. S6. Sensitivity to 6-MP Upon Knockdown of NSD2 in RS4;11 is Not Depedent of Level of Knockdown. S7. Knockdown of NSD2 in WT B-ALL Cell Lines Does Not Lead to Increased Sensitivity. S8. NSD2 WT and EK Overexpression in B-ALL Cell Lines Leads to Distinct Genetic Signature Unique to Each Cell Line. S9. NSD2 WT and EK Overexpression in B-ALL Cell Lines Leads to Distinct Epigenetic Signature Resulting in Gene Expression Changes. S10. NSD2 Knockdown in Mutant B-ALL Cell Lines Leads to Distinct Genetic Signature Unique to Each Cell Line. S11. ATAC peaks significantly correlate with gene expression for RS4;11 and RCH-ACV cell lines.
Supplementary Figure Legends from ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma
Authors: Cramer Gwendolyn M. , Jones Dustin P. , El-Hamidi Hamid , Celli Jonathan P.
Published: April 2023

Captions for supplementary figures
Figure S6 from Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects
Authors: Wang Yao , Stear Jeffrey H. , Swain Ashleigh , Xu Xing , Bryce Nicole S. , Carnell Michael , Alieva Irina B. , Dugina Vera B. , Cripe Timothy P. , Stehn Justine , Hardeman Edna C. , Gunning Peter W.
Published: April 2023

The synergistic anti-cancer efficiency of the drug combinations is well correlated with the combinational impact on mitosis.
Supplemental Figure 4 from ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma
Authors: Cramer Gwendolyn M. , Jones Dustin P. , El-Hamidi Hamid , Celli Jonathan P.
Published: April 2023

S4. Phenotype and treatment response of PANC1 +/- FCM.
Supplementary Figure 2 from Genetic and Epigenetic Inactivation of Extracellular Superoxide Dismutase Promotes an Invasive Phenotype in Human Lung Cancer by Disrupting ECM Homeostasis
Authors: Teoh-Fitzgerald Melissa L.T. , Fitzgerald Matthew P. , Jensen Taylor J. , Futscher Bernard W. , Domann Frederick E.
Published: April 2023

PDF file - 612KB
Supplemental Figure S5AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Authors: Alam Maroof , Ahmad Rehan , Rajabi Hasan , Kufe Donald
Published: April 2023

Supplemental Figure S5AB. A. Lysates from H1299/CshRNA and H1299/MUC1shRNA cells were immunoblotted with the indicated antibodies. B. Representative images of tumorspheres derived from H1299/CshRNA and H1299/MUC1shRNA cells (left). Bar represents 100 microns. The percentage sphere forming efficiency (%SFE) is expressed as the mean{plus minus}SD of three determinations (right).
Supplementary Figure 5 from Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
Authors: Lin Ningjing , Di Chunhui , Bortoff Kathy , Fu Jinrong , Truszkowski Peter , Killela Patrick , Duncan Chris , McLendon Roger , Bigner Darell , Gregory Simon , Adamson David Cory
Published: April 2023

PDF file - 66K
Supplementary Data from Mesothelin Enhances Tumor Vascularity in Newly Forming Pancreatic Peritoneal Metastases
Authors: Avula Leela Rani , Rudloff Michael , El-Behaedi Salma , Arons Danielle , Albalawy Rakan , Chen Xiongfong , Zhang Xianyu , Alewine Christine
Published: April 2023

Figure Legends and Supplementary Methods
Supplementary Figure 2 from Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
Authors: Lin Ningjing , Di Chunhui , Bortoff Kathy , Fu Jinrong , Truszkowski Peter , Killela Patrick , Duncan Chris , McLendon Roger , Bigner Darell , Gregory Simon , Adamson David Cory
Published: April 2023

PDF file - 108K
Supplementary Figures S1-S4 from Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer
Authors: Lin Chi-Iou , Whang Edward E. , Donner David B. , Du Jinyan , Lorch Jochen , He Frank , Jiang Xiaofeng , Price Brendan D. , Moore Francis D. , Ruan Daniel T.
Published: April 2023

Supplementary Figures S1-S4.
Supplementary Data from MYC in Chronic Myeloid Leukemia: Induction of Aberrant DNA Synthesis and Association with Poor Response to Imatinib
Authors: Albajar Marta , Gómez-Casares M. Teresa , Llorca Javier , Mauleon Itsaso , Vaqué Jose P. , Acosta Juan C. , Bermúdez Arancha , Donato Nicholas , Delgado M. Dolores , León Javier
Published: April 2023

Supplementary Figures S1-S3; Supplementary Table S1.
Supplementary Figure 2 from Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells
Authors: Liu Zhiyong , Hartman Yolanda E. , Warram Jason M. , Knowles Joseph A. , Sweeny Larissa , Zhou Tong , Rosenthal Eben L.
Published: April 2023

Supplementary Figure 2 from Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells
Supplementary Table S4 from Interactions with Fibroblasts Are Distinct in Basal-Like and Luminal Breast Cancers
Authors: Camp J. Terese , Elloumi Fathi , Roman-Perez Erick , Rein Jessica , Stewart Delisha A. , Harrell J. Chuck , Perou Charles M. , Troester Melissa A.
Published: April 2023

Supplementary Table S4 from Interactions with Fibroblasts Are Distinct in Basal-Like and Luminal Breast Cancers
Supplementary Data from Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage
Authors: Kaur Sarabpreet , Modi Priyanka , Srivastava Vivek , Mudgal Richa , Tikoo Shweta , Arora Prateek , Mohanty Debasisa , Sengupta Sagar
Published: April 2023

Supplementary Figures S1-S4 and Supplementary Tables S1-S2.
Supplementary Tables 1-3 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Authors: Tworkoski Kathryn , Singhal Garima , Szpakowski Sebastian , Zito Christina Ivins , Bacchiocchi Antonella , Muthusamy Viswanathan , Bosenberg Marcus , Krauthammer Michael , Halaban Ruth , Stern David F.
Published: April 2023

Supplementary Tables 1-3 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Supplementary Table 5 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Authors: Tworkoski Kathryn , Singhal Garima , Szpakowski Sebastian , Zito Christina Ivins , Bacchiocchi Antonella , Muthusamy Viswanathan , Bosenberg Marcus , Krauthammer Michael , Halaban Ruth , Stern David F.
Published: April 2023

Supplementary Table 5 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Supplementary Table 4 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Authors: Tworkoski Kathryn , Singhal Garima , Szpakowski Sebastian , Zito Christina Ivins , Bacchiocchi Antonella , Muthusamy Viswanathan , Bosenberg Marcus , Krauthammer Michael , Halaban Ruth , Stern David F.
Published: April 2023

Supplementary Table 4 from Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma
Supplementary Figure 4 from miR-31 Is a Broad Regulator of β1-Integrin Expression and Function in Cancer Cells
Authors: Augoff Katarzyna , Das Mitali , Bialkowska Katarzyna , McCue Brian , Plow Edward F. , Sossey-Alaoui Khalid
Published: April 2023

PDF file - 69K
Adobe PDF - Supplementary_Data.pdf from Nanoliposomal Short-Chain Ceramide Inhibits Agonist-Dependent Translocation of Neurotensin Receptor 1 to Structured Membrane Microdomains in Breast Cancer Cells
Authors: Heakal Yasser , Kester Mark
Published: April 2023

Adobe PDF - Supplementary_Data.pdf from Nanoliposomal Short-Chain Ceramide Inhibits Agonist-Dependent Translocation of Neurotensin Receptor 1 to Structured Membrane Microdomains in Breast Cancer Cells
Supplementary Data from A Key Role for Early Growth Response-1 and Nuclear Factor-κB in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer
Authors: Wang Bo , Khachigian Levon M. , Esau Luke , Birrer Michael J. , Zhao Xiaohang , Parker M. Iqbal , Hendricks Denver T.
Published: April 2023

Supplementary Data from A Key Role for Early Growth Response-1 and Nuclear Factor-κB in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer
Supplementary Data from Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21
Authors: Leibowitz Brian J. , Qiu Wei , Liu Hongtao , Cheng Tao , Zhang Lin , Yu Jian
Published: April 2023

Supplementary Figures S1-S8; Supplementary Materials and Methods.
Supplementary Data from Tissue Inhibitor of Metalloproteinase-2 Regulates Matrix Metalloproteinase-2–Mediated Endothelial Barrier Dysfunction and Breast Cancer Cell Transmigration through Lung Microvascular Endothelial Cells
Authors: Shen Qiang , Lee Eugene S. , Pitts Robert L. , Wu Mack H. , Yuan Sarah Y.
Published: April 2023

Supplementary Figure S1.
Supplementary Table S1 from Activation of Interferon-Stimulated Genes by γ-Ray Irradiation Independently of the Ataxia Telangiectasia Mutated–p53 Pathway
Authors: Sugihara Takashi , Murano Hayato , Nakamura Masako , Ichinohe Kazuaki , Tanaka Kimio
Published: April 2023

Supplementary Table S1.
Supplementary Data from Constitutive Activation of Caspase-3 and Poly ADP Ribose Polymerase Cleavage in Fanconi Anemia Cells
Authors: Lyakhovich Alex , Surrallés Jordi
Published: April 2023

Supplementary Data from Constitutive Activation of Caspase-3 and Poly ADP Ribose Polymerase Cleavage in Fanconi Anemia Cells
Supplementary Tables S1-S2 from Genes Involved in Differentiation, Stem Cell Renewal, and Tumorigenesis Are Modulated in Telomerase-Immortalized Human Urothelial Cells
Authors: Chapman Emma J. , Kelly Gavin , Knowles Margaret A.
Published: April 2023

Supplementary Tables S1-S2 from Genes Involved in Differentiation, Stem Cell Renewal, and Tumorigenesis Are Modulated in Telomerase-Immortalized Human Urothelial Cells
Supplementary Tables 1-3 from Cytokine Induction of Tumor Necrosis Factor Receptor 2 Is Mediated by STAT3 in Colon Cancer Cells
Authors: Hamilton Kathryn E. , Simmons James G. , Ding Shengli , Van Landeghem Laurianne , Lund P. Kay
Published: April 2023

PDF file - 52K
Supplementary Table 1 from Role of CXCL13-CXCR5 Crosstalk Between Malignant Neuroblastoma Cells and Schwannian Stromal Cells in Neuroblastic Tumors
Authors: Del Grosso Federica , Coco Simona , Scaruffi Paola , Stigliani Sara , Valdora Francesca , Benelli Roberto , Salvi Sandra , Boccardo Simona , Truini Mauro , Croce Michela , Ferrini Silvano , Longo Luca , Tonini Gian Paolo
Published: April 2023

Supplementary Table 1 from Role of CXCL13-CXCR5 Crosstalk Between Malignant Neuroblastoma Cells and Schwannian Stromal Cells in Neuroblastic Tumors
Supplementary Figure 7 from Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer Cells
Authors: Azad Arun , Jackson Susan , Cullinane Carleen , Natoli Anthony , Neilsen Paul M. , Callen David F. , Maira Sauveur-Michel , Hackl Wolfgang , McArthur Grant A. , Solomon Benjamin
Published: April 2023

PDF file - 171K, Induction of accelerated senescence by BEZ235 in irradiated cells is p53-dependent. A, Representative images of SA-�Gal activity cells at 48 hours after 10 Gy radiation (x 200 magnification). B, Western blot showing total p53 and p21 levels in p53-inducible H1299 cells exposed to indicated concentrations (�g/ml) of Ponasterone A (PoA) for 48 hours. C, Representative images of SA-�Gal activity cells in p53-inducible H1299 cells 48 hours after 10 Gy radiation (x 200 magnification). PoA (0.5 �g/ml) was added to growth medium 8 hours prior to irradiation and maintained in growth medium until cells were fixed and stained.
Supplementary Figures S1-S4 from Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes
Authors: Hu Xiaolan , Stern Howard M. , Ge Lin , O'Brien Carol , Haydu Lauren , Honchell Cynthia D. , Haverty Peter M. , Peters Brock A. , Wu Thomas D. , Amler Lukas C. , Chant John , Stokoe David , Lackner Mark R. , Cavet Guy
Published: April 2023

Supplementary Figures S1-S4 from Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes
Supplementary Data from Regional Control of Tumor Growth
Authors: Zaslavsky Alexander , Chen Catherine , Grillo Jenny , Baek Kwan-Hyuck , Holmgren Lars , Yoon Sam S. , Folkman Judah , Ryeom Sandra
Published: April 2023

Supplementary Figures S1-S2.
Supplementary Data from Yin Yang 1 Modulates Taxane Response in Epithelial Ovarian Cancer
Authors: Matsumura Noriomi , Huang Zhiqing , Baba Tsukasa , Lee Paula S. , Barnett Jason C. , Mori Seiichi , Chang Jeffrey T. , Kuo Wen-Lin , Gusberg Alison H. , Whitaker Regina S. , Gray Joe W. , Fujii Shingo , Berchuck Andrew , Murphy Susan K.
Published: April 2023

Supplementary Data from Yin Yang 1 Modulates Taxane Response in Epithelial Ovarian Cancer
Supplementary Data from PRDM1 Is Required for Mantle Cell Lymphoma Response to Bortezomib
Authors: Desai Shruti , Maurin Michelle , Smith Matthew A. , Bolick Sophia C.E. , Dessureault Sophie , Tao Jianguo , Sotomayor Eduardo , Wright Kenneth L.
Published: April 2023

Supplementary Figures S1-S2 and Supplementary Tables S1-S3.
Supplementary Figures S1-S7 from p31comet Induces Cellular Senescence through p21 Accumulation and Mad2 Disruption
Authors: Yun Miyong , Han Young-Hoon , Yoon Sun Hee , Kim Hee Young , Kim Bu-Yeo , Ju Yeun-Jin , Kang Chang-Mo , Jang Su Hwa , Chung Hee-Yong , Lee Su-Jae , Cho Myung-Haing , Yoon Gyesoon , Park Gil Hong , Kim Sang Hoon , Lee Kee-Ho
Published: April 2023

Supplementary Figures S1-S7 from p31comet Induces Cellular Senescence through p21 Accumulation and Mad2 Disruption
Supplementary Data from Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin
Authors: Zhang Jianmin , Song Young-Han , Brannigan Brian W. , Wahrer Doke C.R. , Schiripo Taryn A. , Harris Patricia L. , Haserlat Sara M. , Ulkus Lindsey E. , Shannon Kristen M. , Garber Judy E. , Freedman Matthew L. , Henderson Brian E. , Zou Lee , Sgroi Dennis C. , Haber Daniel A. , Bell Daphne W.
Published: April 2023

Supplementary Data from Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin
Supplementary Data from Relaxin Enhances S100A4 and Promotes Growth of Human Thyroid Carcinoma Cell Xenografts
Authors: Radestock Yvonne , Willing Cornelia , Kehlen Astrid , Hoang-Vu Cuong , Hombach-Klonisch Sabine
Published: April 2023

Supplementary Data from Relaxin Enhances S100A4 and Promotes Growth of Human Thyroid Carcinoma Cell Xenografts
Supplementary Figure 4 from A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
Authors: Guerreiro Ana S. , Fattet Sarah , Kulesza Dorota W. , Atamer Abdullah , Elsing Alexandra N. , Shalaby Tarek , Jackson Shaun P. , Schoenwaelder Simone M. , Grotzer Michael A. , Delattre Olivier , Arcaro Alexandre
Published: April 2023

Supplementary Figure 4 from A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
Supplementary Data from Fibulin-3 Is Uniquely Upregulated in Malignant Gliomas and Promotes Tumor Cell Motility and Invasion
Authors: Hu Bin , Thirtamara-Rajamani Keerthi K. , Sim Hosung , Viapiano Mariano S.
Published: April 2023

Supplementary Data from Fibulin-3 Is Uniquely Upregulated in Malignant Gliomas and Promotes Tumor Cell Motility and Invasion
Supplementary Figure 3 from A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
Authors: Guerreiro Ana S. , Fattet Sarah , Kulesza Dorota W. , Atamer Abdullah , Elsing Alexandra N. , Shalaby Tarek , Jackson Shaun P. , Schoenwaelder Simone M. , Grotzer Michael A. , Delattre Olivier , Arcaro Alexandre
Published: April 2023

Supplementary Figure 3 from A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
Supplementary Figure 2 from A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
Authors: Guerreiro Ana S. , Fattet Sarah , Kulesza Dorota W. , Atamer Abdullah , Elsing Alexandra N. , Shalaby Tarek , Jackson Shaun P. , Schoenwaelder Simone M. , Grotzer Michael A. , Delattre Olivier , Arcaro Alexandre
Published: April 2023

Supplementary Figure 2 from A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
Supplementary Data from Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells
Authors: Ishimaru Daniella , Ramalingam Sivakumar , Sengupta Tapas K. , Bandyopadhyay Sumita , Dellis Stephanie , Tholanikunnel Baby G. , Fernandes Daniel J. , Spicer Eleanor K.
Published: April 2023

Supplementary Data from Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells
Supplementary Data from Enhanced Susceptibility to Chemical Induction of Ovarian Tumors in Mice with a Germ Line p53 Mutation
Authors: Wang Yian , Zhang Zhongqiu , Lu Yan , Yao Ruisheng , Jia Dongmei , Wen Weidong , LaRegina Marie , Crist Keith , Lubet Ronald , You Ming
Published: April 2023

Supplementary Data from Enhanced Susceptibility to Chemical Induction of Ovarian Tumors in Mice with a Germ Line p53 Mutation
Supplementary Movie 1 from Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor–Induced Cell Motility of Human Synovial Sarcoma Cell Lines
Authors: Watanabe Takuya , Tsuda Masumi , Makino Yoshinori , Ichihara Shin , Sawa Hirofumi , Minami Akio , Mochizuki Naoki , Nagashima Kazuo , Tanaka Shinya
Published: April 2023

Supplementary Movie 1 from Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor–Induced Cell Motility of Human Synovial Sarcoma Cell Lines
Supplementary Movie S2B from Oligodendrocyte Lineage Transcription Factor 2 Inhibits the Motility of a Human Glial Tumor Cell Line by Activating RhoA
Authors: Tabu Kouichi , Ohba Yusuke , Suzuki Tadaki , Makino Yoshinori , Kimura Taichi , Ohnishi Akiko , Sakai Mieko , Watanabe Takuya , Tanaka Shinya , Sawa Hirofumi
Published: April 2023

Supplementary Movie S2B from Oligodendrocyte Lineage Transcription Factor 2 Inhibits the Motility of a Human Glial Tumor Cell Line by Activating RhoA
Supplementary Figures S1-S3 from Oligodendrocyte Lineage Transcription Factor 2 Inhibits the Motility of a Human Glial Tumor Cell Line by Activating RhoA
Authors: Tabu Kouichi , Ohba Yusuke , Suzuki Tadaki , Makino Yoshinori , Kimura Taichi , Ohnishi Akiko , Sakai Mieko , Watanabe Takuya , Tanaka Shinya , Sawa Hirofumi
Published: April 2023

Supplementary Figures S1-S3 from Oligodendrocyte Lineage Transcription Factor 2 Inhibits the Motility of a Human Glial Tumor Cell Line by Activating RhoA
Supplementary Material -Table Legends, Figures and Legends 1-3 from Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
Authors: Kuznetsoff Jeffim N. , Owens Dawn A. , Lopez Andy , Rodriguez Daniel A. , Chee Nancy T. , Kurtenbach Stefan , Bilbao Daniel , Roberts Evan R. , Volmar Claude-Henry , Wahlestedt Claes , Brothers Shaun P. , Harbour J. William
Published: April 2023

S1. Doxycycline-inducible shRNA knockdown of BAP1 results in robust decrease of GLO1 expression in uveal melanoma cell lines. S2. Phenotypic rescue and toxicity analysis of three HDAC inhibitors in Xenopus embryos injected with control morpholino CtrlMO or bap1-targeting morpholino BAP1MO. S3. Quisinostat and trametinib combination exhibits mostly additive cytotoxic effect in uveal melanoma in vitro.
Supplementary Data from Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype
Authors: Hanley Christopher J. , Henriet Elodie , Sirka Orit Katarina , Thomas Gareth J. , Ewald Andrew J.
Published: April 2023

Supplementary Materials and Methods. Figure S1. Weighted gene correlation network analysis of RNA-Sequencing from human invasive ductal breast cancer primary tumor samples.Figure S2: Physical interaction between stromal cells and invasive organoids.Figure S3: TGF-β-NOX4 regulate stromal cell activation and reciprocal induction of tumor cell invasion. Supplementary Figure, Movie, and Table Legends.
Supplemental Video 2 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Authors: Beck Anna C. , Cho Edward , White Jeffrey R. , Paemka Lily , Li Tiandao , Gu Vivian W. , Thompson Dakota T. , Koch Kelsey E. , Franke Christopher , Gosse Matthew , Wu Vincent T. , Landers Shannon R. , Pamatmat Anthony J. , Kulak Mikhail V. , Weigel Ronald J.
Published: April 2023

Supplemental Video KO Cells
Supplementary Tables 1-8 from Colorectal Cancer–Derived CAT1-Positive Extracellular Vesicles Alter Nitric Oxide Metabolism in Endothelial Cells and Promote Angiogenesis
Authors: Ikeda Atsushi , Nagayama Satoshi , Sumazaki Makoto , Konishi Makoto , Fujii Risa , Saichi Naomi , Muraoka Satoshi , Saigusa Daisuke , Shimada Hideaki , Sakai Yoshiharu , Ueda Koji
Published: April 2023

Table S1. Clinical information and protein abundances in LC/MS analysis of the CRC patients and the healthy donors. Table S2: The list of identified 8,565 CRC tissue proteins. Table S3: The list of identified 6,307 CRC Te-EV proteins. Table S3: The list of identified 6,307 CRC Te-EV proteins. Table S4: The 487 EV biomarker candidates for CRC (adjusted p < 0.05 and Fold-change > 5.0, paired t-test). Table S5. The focused 11 EV biomarker candidates for CRC selected as surface antigens for EV-sandwich ELISA (adjusted p < 0.05 and Fold-change > 5.0, paired t-test). Table S6. Enriched GO terms of biological process (up-regulated 487 proteins in tumor Te-EVs). Table S7. Top 100 of up-regulated and down-regulated Te-EV proteins compared with tissue proteins. Table S8a. Enriched KEGG pathways (up-regulated 487 proteins in tumor Te-EVs). Table 8b: Enriched KEGG pathways (down-regulated 88 proteins in tumor Te-EVs).
Supplemental Video 1 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Authors: Beck Anna C. , Cho Edward , White Jeffrey R. , Paemka Lily , Li Tiandao , Gu Vivian W. , Thompson Dakota T. , Koch Kelsey E. , Franke Christopher , Gosse Matthew , Wu Vincent T. , Landers Shannon R. , Pamatmat Anthony J. , Kulak Mikhail V. , Weigel Ronald J.
Published: April 2023

Supplemental Video 1 Parental Cells
Supplementary Figure Legends from Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B.
Published: April 2023

Figure Legends
Figure S4 from Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B.
Published: April 2023

Sequence alignment of human, mouse, and chicken FANCJ
Supplementary Table 1 from Extracellular Matrix–Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer
Authors: DiGiacomo Josh W. , Godet Inês , Trautmann-Rodriguez Michael , Gilkes Daniele M.
Published: April 2023

Primer Sequences
Table S4 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Table S4. Multivariable analyses of clinic-pathologic parameters with MGMT methylation status in patient with GBM
Table S1 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Table S1. Primers used in the study
Table S3 from IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability
Authors: Leone Marina , Cazorla-Vázquez Salvador , Ferrazzi Fulvia , Wiederstein Janica L. , Gründl Marco , Weinstock Grit , Vergarajauregui Silvia , Eckstein Markus , Krüger Marcus , Gaubatz Stefan , Engel Felix B.
Published: April 2023

IQGAP3 expression in human cervical cancers
Figure S4 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S4 miR-146a significantly inhibited the NF-κB and ERK pathways in GBM
Table S3 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
Authors: Yang Jianjian , Wang Xue , Huang Bing , Liu Rong , Xiong Hui , Ye Fan , Zeng Chenxi , Fu Xiangning , Li Lequn
Published: April 2023

Table S3. Clinicopathological variables and gene expression in tumors.
Supplementary Figure Legends from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
Authors: Yang Jianjian , Wang Xue , Huang Bing , Liu Rong , Xiong Hui , Ye Fan , Zeng Chenxi , Fu Xiangning , Li Lequn
Published: April 2023

Supplementary Figure Legends 1-4 legends 1-4
Figure S11 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S11 Expression of SMARCA5 in TCGA datasets
Figure S10 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S10 Expression of POU3F2 in TCGA datasets
Figure S3 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
Authors: Yang Jianjian , Wang Xue , Huang Bing , Liu Rong , Xiong Hui , Ye Fan , Zeng Chenxi , Fu Xiangning , Li Lequn
Published: April 2023

S3. Downregulation of gene expression by RNA interference.
Supplementary Table 3 from TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells
Authors: Wen Fuping , Sun Xiaochen , Sun Chenxia , Dong Zhenyang , Jia Gaozhen , Bao Wei , Yu Haolan , Yang Chenghua
Published: April 2023

GSEA result for 66 prostate cancer samples
Figure S1 from An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma
Authors: Yang Jianjian , Wang Xue , Huang Bing , Liu Rong , Xiong Hui , Ye Fan , Zeng Chenxi , Fu Xiangning , Li Lequn
Published: April 2023

S1. Detection of ZEB1 protein expression in tumors.
Supplementary Table 2 from TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells
Authors: Wen Fuping , Sun Xiaochen , Sun Chenxia , Dong Zhenyang , Jia Gaozhen , Bao Wei , Yu Haolan , Yang Chenghua
Published: April 2023

GSEA result for shTAGLN cells
Figure S7 from Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Authors: Li Deng-Ke , Chen Xing-Rui , Wang Li-Na , Wang Jia-Hong , Wen Yue-Ting , Zhou Zi-Ying , Li Ji-Ke , Liu Jing-Xian , Cai Lin-Bo , Zhong Shui-Sheng , Lyu Xiao-Ming , Damola Faleti Oluwasijibomi , Li Min-Ying , Zhang Jing-Jing , Zeng Yu-Mei , Wang Qian-Li , Zhang Qian-Bing , Lyu Hao , Fu Xiao-Yan , Wang Wei , Li Xin , Huang Zhong-Xi , Yao Kai-Tai
Published: April 2023

EBV is not correlated with lymphangiogenesis in GC
Figure S5 from Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Authors: Li Deng-Ke , Chen Xing-Rui , Wang Li-Na , Wang Jia-Hong , Wen Yue-Ting , Zhou Zi-Ying , Li Ji-Ke , Liu Jing-Xian , Cai Lin-Bo , Zhong Shui-Sheng , Lyu Xiao-Ming , Damola Faleti Oluwasijibomi , Li Min-Ying , Zhang Jing-Jing , Zeng Yu-Mei , Wang Qian-Li , Zhang Qian-Bing , Lyu Hao , Fu Xiao-Yan , Wang Wei , Li Xin , Huang Zhong-Xi , Yao Kai-Tai
Published: April 2023

VEGF-C is required for EBV-induced lymphatic metastasis in vivo
Supplementary Figures 1-9 from Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation
Authors: Sato Tatsuhiro , Mukai Satomi , Ikeda Haruna , Mishiro-Sato Emi , Akao Ken , Kobayashi Toshiyuki , Hino Okio , Shimono Wataru , Shibagaki Yoshio , Hattori Seisuke , Sekido Yoshitaka
Published: April 2023

Figure S1. RHEB mRNA expression in different types of cancer. Figure S2. In vivo growth of MeT-5A mesothelial cells expressing exogenous RHEBL1. Figure S3. RHEBL1 binds to SmgGDS. Figure S4. SmgGDS knockdown suppresses the proliferation of mesothelial cells expressing exogenous RHEBL1. Figure S5. SmgGDS knockdown suppresses the growth of PTEN-deficient MM cells in vitro. Figure S6. Subcellular RHEBL1 localization. Figure S7. SmgGDS knockdown alters RHEBL1 localization in PTEN-deficient MM cells. Figure S8. Amino acid stimulation does not affect RHEBL1 subcellular localization. Figure S9. RHEBL1 farnesylation is essential for SmgGDS binding.
Movie 3 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase
Authors: Ginzel Joshua D. , Acharya Chaitanya R. , Lubkov Veronica , Mori Hidetoshi , Boone Peter G. , Rochelle Lauren K. , Roberts Wendy L. , Everitt Jeffrey I. , Hartman Zachary C. , Crosby Erika J. , Barak Lawrence S. , Caron Marc G. , Chen Jane Q. , Hubbard Neil E. , Cardiff Robert D. , Borowsky Alexander D. , Lyerly H. Kim , Snyder Joshua C.
Published: April 2023

p95HER2 invasive carcinoma. p95HER2 shown in magenta. Krt14 antibody staining shown in green.
Movie 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase
Authors: Ginzel Joshua D. , Acharya Chaitanya R. , Lubkov Veronica , Mori Hidetoshi , Boone Peter G. , Rochelle Lauren K. , Roberts Wendy L. , Everitt Jeffrey I. , Hartman Zachary C. , Crosby Erika J. , Barak Lawrence S. , Caron Marc G. , Chen Jane Q. , Hubbard Neil E. , Cardiff Robert D. , Borowsky Alexander D. , Lyerly H. Kim , Snyder Joshua C.
Published: April 2023

p95HER2 labelled sidebuds. p95HER2 shown in magenta. Krt14 antibody staining shown in green.
Supplementary Figure 3 from NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells
Authors: Jilishitz Irina , Quiñones Jason Luis , Patel Priyank , Chen Grace , Pasetsky Jared , VanInwegen Allison , Schoninger Scott , Jogalekar Manasi P. , Tsiperson Vladislav , Yan Lingyue , Wu Yun , Gottesman Susan R.S. , Somma Jonathan , Blain Stacy W.
Published: April 2023

ERalpha status of cell lines and ALT is delivered to normal cells.
Supplementary Figure 2A-I from NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells
Authors: Jilishitz Irina , Quiñones Jason Luis , Patel Priyank , Chen Grace , Pasetsky Jared , VanInwegen Allison , Schoninger Scott , Jogalekar Manasi P. , Tsiperson Vladislav , Yan Lingyue , Wu Yun , Gottesman Susan R.S. , Somma Jonathan , Blain Stacy W.
Published: April 2023

Biophysical & Biochemical Characterization of NP-ALT.
Supplemental Figures 1-12 from Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft
Authors: Morton J. Jason , Alzofon Nathaniel , Keysar Stephen B. , Chimed Tugs-Saikhan , Reisinger Julie , Perrenoud Loni , Le Phuong N. , Nieto Cera , Gomez Karina , Miller Bettina , Yeager Randi , Gao Dexiang , Tan Aik-Choon , Somerset Hilary , Medina Theresa , Wang Xiao-Jing , Wang Jing H. , Robinson William , Roop Dennis R. , Gonzalez Rene , Jimeno Antonio
Published: April 2023

S1. The peripheral blood of the CUHM003 and CUHM005 mHM and aHM cohorts contains distinct populations of human CD19+45+ B cells. S2. Human CD45+ blood cell and CD34+45+ HSPC populations in CUHM003 and CUHM005 mHM and aHM bone marrow. S3. The aHM and mHM spleens also contain human immune cells. S4. Altered growth dynamics of HLA-A matched tumors and aHM treated tumors. S5. Altered growth dynamics of individual aHM tumors after immunedirected therapies. S6. A relatively small number of immune cells were capable of invading both mHM and aHM tumors, notwithstanding their relative abundance in the bone marrow. S7. IHC comparing T cell, B cell and macrophage invasion in CUHM003 (A) and CUHM005 (B) tumors. S8. Gene mutations within the patient germline, tumor at diagnosis, tumor at progression, and tumors within treated mouse model systems. S9. GSEA hallmark profile of the CUHM003 and CUHM005 NSG, mHM, and aHM tumors. S10. Differential expression in IFN and Jak-STAT pathway genes in aHM tumors. S11. Graph showing the qPCR to verify knockdown of IFNγR2 in transfected cell lines. S12. Cytokine array data from CUHM003 and CUHM005 mHM and aHM mice, depicted as a heatmap.
Supplementary Table 1 from The PI3K/mTOR Inhibitor Ompalisib Suppresses Nonhomologous End Joining and Sensitizes Cancer Cells to Radio- and Chemotherapy
Authors: Du Jie , Chen Fuqiang , Yu Jiahua , Jiang Lijun , Zhou Meijuan
Published: April 2023

Table S1. List of 28 hits from primary screen. The CAS No. and tradenames of each drug are also listed.
Supplementary Figure 1 from Long Noncoding RNA NEAT1 Acts as a Molecular Switch for BRD4 Transcriptional Activity and Mediates Repression of BRD4/WDR5 Target Genes
Authors: Pistoni Mariaelena , Rossi Teresa , Donati Benedetta , Torricelli Federica , Polano Maurizio , Ciarrocchi Alessia
Published: April 2023

Supplementary Figure 1. The differentially expressed lncRNAs, peaks of BRD4 enrichment on lncRNA NEAT1 and lncNEAT1 expression and modulation.
Supplemental Figures 1-6, Supplemental Table Legends 1-3 from SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells
Authors: Terai Hideki , Hamamoto Junko , Emoto Katsura , Masuda Takeshi , Manabe Tadashi , Kuronuma Satoshi , Kobayashi Keigo , Masuzawa Keita , Ikemura Shinnosuke , Nakayama Sohei , Kawada Ichiro , Suzuki Yusuke , Takeuchi Osamu , Suzuki Yukio , Ohtsuki Sumio , Yasuda Hiroyuki , Soejima Kenzo , Fukunaga Koichi
Published: April 2023

Figure S1. Overview of the CRISPR/Cas9 screen performed in EGFR mutation positive NSCLC PC9 cells. Figure S2. Cell viability assay of cytotoxic agents or ALK-TKI in SHOC2-depleted cells. Figure S3. Supplementary data for domain analysis. Figure S4. Supplementary data for phospho-proteomics analysis. Figure S5. Cell viability assay of celastrol in PC9 and H1975 cells. Figure S6. Supplementary data for xenograft model. Supplemental Table Legends 1-3