bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression and localization of efflux drug transporters P-glycoprotein and breast cancer resistance protein (BCRP) in adult human pancreatic islet alpha and beta cells
Authors: Kwon Jihoon , Hwang Jaehyun , Kim Michelle S. , Tirona Rommel G. , Kim Richard B. , Wang Rennian , Schwarz Ute I.
Published: May 2023

P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are clinically important efflux transporters of the ATP-binding cassette (ABC) family of transporters, widely recognized for their broad substrate specificity associated with multidrug resistance in cancers and limiting substrate drug intracellular accumulation. While their expression and function in organs such as the intestine, liver and kidneys are well understood, there is little known concerning pancreatic islet cells. This study was aimed to characterize the expression and localization of P-gp and BCRP transporters in adult human pancreatic islets using quantitative reverse transcription PCR (qPCR) and dual immunofluorescent staining approaches. We showed that P-gp and BCRP were highly expressed in the islets compared to liver, and frequently colocalized with insulin or glucagon. These findings provide new insights regarding P-gp and BCRP abundance in beta and alpha cells suggesting a potential role for these efflux transporters in limiting islet cell injury to xenobiotics.
Nosemosis in Türkiye: Increasing prevalence and distribution on two decades, and phylogenetic network analysis based on SSU rRNA gene
Authors: AKPINAR Rahşan Koç , GÜRLER Ali Tümay , BÖLÜKBAŞI Cenk Soner , KAYA Selma , ARSLAN Serhat , AYDIN Coşkun , Türlek Şakir Önder , Çelik Sema Nur , Beyazıt Ayşen , Öncel Tareneh , Erol Ufuk , Çiftci Ayşe Türkan , Bastem Zekai , Şenel Mesut , Bozdeveci Arif , Karaoğlu Şengül Alpay , Yaldız Murat , Güven Gökhan , Küçükoğlu Bilal , Kurt Mitat
Published: May 2023

Nosemosis, one of the most important honeybee diseases, causes colony losses and low productivity worldwide. A national study were carried out to presence of nosemosis throughout Türkiye, determine the prevalence of Nosema cereane and Nosema apis, and perform the network analyses of the parasites. Specimens were collected from hives with no clinical signs. A total of 1194 European honey bee colonies in 400 apiaries from 40 provinces of Türkiye were examined by microscopic and molecular techniques. Nosemosis were found in all of 40 provinces. The prevalence ratio were 64.3 ± 3,0, 95%CI in apiaries and 40.5 ± 2,9, 95%CI in hives. N. ceranae DNA were detected all of positive hives, while N. ceranae and N. apis co-infection in only four colonies. In the last two decades, it has been observed that nozemosis has spread to all provinces and its prevalence has increased in all regions of Türkiye. All of the N. ceranae or N. apis samples examined were 100% identical within themselves. Network analysis showed that they were within largest haplotype reported worldwide.
Affine-Periodic Solutions for Newton systems
Authors: Guo Ruichao , Wang Hongren
Published: May 2023

This paper establishs existence theorem of affine-periodic solutions for second order Newton system via topological degree theory. The concept of affine-periodicity performs not only a kind of symmetry of space but also the periodic evolution of time, which is a general version of periodicity, anti-periodicity, harmonic-periodicity and quasi-periodicity.
AMS(MOS). Mathematics Subject Classification(2000): 34C25, 34B15, 47H11
Causal Relationship Between Gut Microbiome and Allergic Asthma: A Two-Sample Mendelian Randomization Study
Authors: Wan Wei , Qiu Yi , Ren Yingxiang , Huang Xinyi , Peng Andi , Yang Chunping
Published: May 2023

Background Growing evidence has well documented the close association between the gut microbiome and allergic respiratory disease, which has been notably represented by allergic asthma. However, it is unclear whether this association is a causal link. Therefore, we investigated the potential causal associations between the gut microbiome and allergic asthma or other allergic diseases.Methods In this study, we performed two-sample Mendelian randomization(MR) analyses by using the publicly available genome-wide association study (GWAS) summary data. Single-nucleotide polymorphisms (SNPs) that significantly correlated were selected as instrumental variables. The inverse variance weighted (IVW) method was used to examine the potential causal gut microbial genera for allergic asthma and other allergic diseases. The robustness of the primary findings of the MR analyses was ensured by using different sensitivity analyses.Results Combining the findings from multiple analyses, the host genetic-driven increases in Butyricimonas at the genus level were positively correlated with the risk of allergic asthma. In addition, phylum Bacteroidetes, class Bacteroidia, order Bacteroidales was also found to have negative associations with the risk of allergic asthma; genus Slackia was identified as having potential causal effects with allergic asthma. No clear evidence of pleiotropy and heterogeneity was observed in Butyricimonas. Butyricimonas was also found to have an association with allergic rhinitis, but not with other allergic diseases.Conclusion Our findings indicate that there are new gut microbial genera that were causally associated with the risk of allergic asthma and other allergic diseases, and offer novel insights into the pathogenesis of allergic respiratory diseases.
Comprehensive characterization and electrochemical performance of Fe-doped Co 3 O 4 nanoparticles for energy storage applications
Authors: Karthikeyan A. , Mariappan R. , Bakkiyaraj R. , Senthosh S.
Published: May 2023

This study investigates the structural, spectroscopic, and electrochemical properties of Fe-doped cobalt oxide nanoparticles (Fe-doped Co3O4 Nps). X-ray diffraction (XRD) analysis reveals that the Fe-doped samples have a spinel cubic Co3O4 structure with peaks corresponding to (220), (311), (400), (511), and (400) reflection planes. Fourier-transform infrared (FTIR) analysis shows that the major peaks correspond to Co2+ and Co3+ vibrations in the spinel Co3O4 crystal structure, and their positions shift with the increase in Fe doping concentration. X-ray photoelectron spectroscopy (XPS) studies confirm the presence of Co2+ and Co3+ in the Co 2p spectrum and identify Fe3+ and Fe2+ in the Fe 2p spectrum. Scanning electron microscopy (SEM) reveals the surface morphology of the Fe-doped Co3O4 Nps, showing hexagonal/granular structures with varying pore sizes. High-resolution transmission electron microscopy (HR-TEM) analysis confirms the nanocrystalline nature of the Fe-doped Co3O4 Nps. Energy-dispersive X-ray spectroscopy (EDAX) elemental analysis confirms the presence of Co, O, and Fe in the doped samples. Electrochemical studies, including cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) tests, demonstrate the electrochemical performance of the Fe-doped Co3O4 Nps. The specific capacitance of the samples increases with the increase in Fe doping concentration, indicating improved rate capabilities and ion diffusion. Overall, Fe doping enhances the structural and electrochemical properties of Co3O4 Nps, making them promising materials for various applications.
Spatial and temporal evolution characteristics and influencing factors of coupling coordination degree of urbanization and eco-environment in the Huaihe Eco-economic Belt
Authors: Yao Xiamei , Chen Yuanyuan , Sheng Yutian , Qi Huimin , Zhang Qingyi , Ou Chun
Published: May 2023

The rapid development of urbanization in recent years has brought about economic and social development, but has led to a series of problems in the eco-environment. On the basis of the evaluation model of urbanization and eco-environment constructed for the Huaihe Eco-economic Belt, a comprehensive analysis of the coupling coordination degree between the two was conducted from 2005 to 2020, and the aggregation characteristics in space were explored, as well as the reasons for the uneven development of urbanization and eco-environment were revealed. The results show that: (1) between 2005 and 2020, the development level and the coupling coordination degree of urbanization and eco-environment in the Huaihe Eco-economic Belt all increased steadily. (2) In terms of global spatial autocorrelation, urbanization and coupling coordination showed a strong positive correlation in 2005, but weakened year by year as time progressed, while eco-environment shows a random spatial distribution. In terms of local autocorrelation, in 2005, urbanization local autocorrelation was mainly clustered in Shandong and Jiangsu Province, but both became more and more spatially dispersed as time progressed. (3) Spatial urbanization was the main aspect affecting the uneven level of urbanization in the Huaihe Eco-economic Belt in 2005, and by 2020, population urbanization had become a relatively weak aspect of urbanization in many cities, including Taizhou, Yancheng and Pingdingshan. In terms of eco-environment, between 2005 and 2015, ecological pressure became a problem for many cities, but in 2020, ecological pressure has weakened again, and soon the state of eco-environment has become a new weak point. The development of central cities such as Bengbu and Huai’an should be strengthened, talents should be retained, the urbanization rate of the population should be increased, and relevant environmental protection policies should be implemented to promote the sustainable development of cities within the Huaihe Eco-economic Belt.
Unravelling the Belgian cascade of hypertension care and its determinants
Authors: Bos Philippe , Danhieux Katrien , Wouters Edwin , Olmen Josefien Van , Remmen Roy , Klipstein-Grobusch Kerstin , Boateng Daniel , Buffel Veerle
Published: May 2023

Objective. To use a cascade of care approach to identify where most patients are lost along the continuum of hypertension care in Belgium, and to assess the main risk factors for attrition at various stages of hypertension management.
Methods. Using cross-sectional data from the 2018 Belgian Health Interview Survey and Belgian Health Examination Survey, we estimated hypertension prevalence among the Belgian population aged 40-79 years, and the proportion that was (1) screened, (2) diagnosed, (3) linked to care, (4) in treatment, (5) followed up and (6) well-controlled. Cox regression was used to identify risk factors for being unlinked to hypertension care, untreated and not followed up appropriately.
Results. The prevalence of hypertension based on self-reported and measured high blood pressure (BP) was 43.3%. While 98% of the hypertensive population had their BP measured in the past 5 years, only 56.7% was diagnosed. Furthermore, 53.4% of the hypertensive population was linked to care, 49.8% was in treatment and 43.4% received adequate follow-up. Less than a quarter (23.5%) achieved BP control. Males, those of younger age, without comorbidity, and smokers, were more likely to be unlinked to care. Younger age, lower BMI, financial hardship, and psychological distress were associated with a higher risk of being untreated. Finally, females, those of younger age, and without comorbidity were more likely to receive no adequate follow-up.
Conclusion. Our results show that undiagnosed hypertension is the most significant barrier to BP control in Belgium. Health interventions are needed to improve the accurate and timely diagnosis of hypertension.
Kaempferol suppresses inflammation in mice suffering from both hyperuricemia and gouty arthritis through inhibiting NLRP3 inflammasome and NF-κB pathway
Authors: Huang Yan , Li Cantao , Xu Wenjing , Li Fenfen , Xu Changyu , Wu Chenxi , Wang Yihuan , Zhang Xiaoxi , Xia Daozong
Published: May 2023

The co-occurrence of hyperuricemia and gouty arthritis is common in patients, yet a suitable animal model for this condition is lacking. In present study, a mice model combined hyperuricemia and gouty arthritis was established. Kaempferol, a flavonoid compound with anti-inflammatory and urate-lowering properties, was administered to mice in different dosages (25, 50, and 100 mg/kg). The levels of uric acid, creatinine, blood urea nitrogen and xanthine oxidase activity were measured, then kidney and joint ankle tissues were examined for pathological changes. The expressions of renal transporters, oxidative stress and inflammatory cytokines were detected. Furthermore, the anti-inflammatory mechanism of kaempferol was verified from NOD-like receptor protein 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-κB) pathway. The results of histological analyses showed that kaempferol ameliorated the glomerular and renal tubular lesions and ankle arthritis inflammatory infiltration caused by hyperuricemia combined with gouty arthritis. Additionally, treatment with kaempferol effectively alleviated oxidative stress and decreased the levels of pro-inflammatory cytokines. The research confirmed that kidney and joint inflammation in hyperuricemia combined with gouty arthritis mice were alleviated by kaempferol via suppressing NLRP3 inflammasome and NF-κB pathway.
Alterations in the oral microbiome and metabolome of methamphetamine addicts
Authors: Wang Dawei , Feng Yu , Yang Min , Sun Haihui , Zhang Qingchen , Wang Rongrong , Tong Shuqing , Su Rui , Jin Yan , Wang Yunshan , Lu Zhiming , Han Lihui , Sun Yundong
Published: May 2023

Background: Drug addiction can seriously damage human physical and mental health, while detoxification is a long and difficult process. Although studies have reported changes in the oral microbiome of methamphetamine (METH) addicts, the role of the microbiome plays in this process is still unknown. This study aims to explore the function of the microbiome based on analysis of the variations in the oral microbiome and metabolome of METH addicts.
Results: We performed the 16S rRNA sequencing analysis based on the oral saliva samples collected from 278 METH addicts and 105 healthy controls (CTL) undergoing detoxification at the detoxification center in Shandong, China. In addition, the untargeted metabolomic profiling was conducted based on 220 samples (170 METH addicts and 50 CTL) to identify the biomarkers and build classifiers for both oral microbiota and metabolites.
Compared to the CTL group, alpha diversity was reduced in the group of METH addicts, with significant differences in the microbiota and changes in oral metabolic pathways, including enhanced tryptophan metabolism, lysine biosynthesis, purine metabolism, and steroid biosynthesis. Conversely, the metabolic pathways of porphyrin metabolism, glutathione metabolism, and pentose phosphate were significantly reduced. It was speculated that four key microbial taxa, i.e., Peptostreptococcus, Gemella, Campylobacter, and Aggregatibacter, could be involved in the toxicity and addiction mechanisms of METH by affecting the above metabolic pathways. In addition, microbial prediction models were more effective than metabolite-based prediction models in identifying METH addiction.
Conclusions: Our study identified the potential functional connections between the oral microbiome and metabolic profile of METH addicts, providing novel insights into exploring the toxic damage and addiction mechanisms underlying the METH addiction.
Limitations in historical satellite archives bias SDG monitoring
Authors: Conrad Christopher , Meyer Carsten , Remelgdo Ruben
Published: May 2023

Satellite remote sensing is vital to monitoring, research, and policy addressing sustainability challenges from climate and ecosystem changes to food and water security. Here, Landsat satellite data play a crucial role, thanks to their unique global, long-term, and high-resolution coverage. Yet, disregarded biases in the Landsat data archive threaten the validity of their applications. Here, we demonstrate that global Landsat data are spatiotemporally highly uneven, frequently interrupted, and have seasonally incomplete coverage and quality. We show that these limitations are inherited in prominent global time-series products, leading to biased perceptions of changes in forests, croplands, and water resources that impair reliable assessments of related sustainability issues. Several data limitations and their biasing effects disproportionately affect lower-income countries. We provide global data-quality information to support their explicit consideration in future mapping efforts. Our results call for better data-bias reporting and control in satellite-based sustainability monitoring and analyses.
Ensimmäinen. Carl Eneas Sjöstrandin istuva Porthan
Authors: Siukonen Jyrki
Published: May 2023

The First-ever. Porthan statue by Carl Eneas Sjöstrand The nineteenth century has been called an age of monuments. In some places even one piece made a difference. This book is a study of the intellectual background and physical making of Finland’s first public sculpture, the statue of Professor Henrik Gabriel Porthan by Carl Eneas Sjöstrand. The idealised but sombre Porthan was born under the influence of German neoclassicism. Development on the project was slow but sure. The Swedish artist had to be supported over three years while he was putting together his first monumental piece in Munich and Rome, after which came another three years wait before the cast arrived to Finland. The bronze sculpture, commissioned by the Finnish Literary Society and raised by public subscriptions from people of all classes, was unveiled in the city of Turku in September 1864. Finns took some pride in the fact that, unlike other nations that had raised monuments to kings and generals, here the first place was given to a scholar. In this study Sjöstrand’s pioneering bronze is placed in a wider context and compared with works by his precursors and contemporaries in the international sculptor colony of Rome.
Sıcak Asfalt Karışımlarında Filler Olarak Kullanılan Farklı Kireçlerin Kaplama Performansına Etkilerinin İncelenmesi
Authors: KIRBAŞ Ufuk , SÖZEN Eray , GENÇ Zafer
Published: May 2023

Çalışmada, sıcak karışım asfaltlarda filler yerine üç farklı menşeili kirecin belirli oranlarda karışımda kullanımının etkileri araştırılmıştır. Samsun ili Kavak ilçesinde bulunan ocaklardan üretilen üç farklı sönmüş toz kirecin, sıcak asfalt karışımlarında farklı oranlarda filler olarak kullanılması durumunda karışımın performans değişimleri incelenmiştir. Çalışmada sıcak karışım asfalt numuneleri, kireçsiz numunelerin yanında karışım içerisindeki filler miktarı %0.5, %1, %1.5, %2 oranlarında azaltılarak yerine aynı miktarda temin edilen üç farklı menşeili kireç ilave edilerek hazırlanmıştır. Ardından, su hasarının sıcak karışım asfaltın performansına etkilerini karşılaştırmak ve araştırmak için aynı numune grubu tekrar üretilerek AASHTO T 283 standardına göre koşullandırılmıştır. Marshall stabilite ve akma değerlerine göre her iki grup numunenin sonuçları karşılaştırılmıştır. Yapılan analizlerde her iki durumda da CaO ve MgO toplamının Karayolları Teknik Şartnamesinde (KTŞ) önerilen %90 eşiğinden büyük olmasının ve SO3’ün KTŞ’de önerilen %2 eşiğinden küçük olmasının üstyapı performansını arttırır şekilde etkili olduğu tespit edilmiştir.
Competitive study of homogeneous and heterogeneous Fenton-like flow-through propoxur oxidation in ROC solution
Authors: Azaiza Abed-Alhakeem , Semiat Raphael , Shemer Hilla
Published: May 2023

Reverse osmosis is used as a tertiary treatment for wastewater reclamation. However, sustainable management of the concentrate (ROC) is challenging, due to the need for treatment and/or disposal. The objective of this research was to investigate the efficiency of homogeneous and heterogeneous Fenton-like oxidation processes in removing propoxur (PR), a micro-pollutant compound, from synthetic ROC solution in a submerged ceramic membrane reactor operated in a continuous mode. A freshly prepared amorphous heterogeneous catalyst was synthesized and characterized, revealing a layered porous structure of 5–16 nm nanoparticles that formed aggregates (33–49 μm) known as ferrihydrite (Fh). The membrane exhibited a rejection of >99.6% for Fh. The homogeneous catalysis (Fe3+) exhibited better catalytic activity than the Fh in terms of PR removal efficiencies. However, by increasing the H2O2 and Fh concentrations at a constant molar ratio, the PR oxidation efficiencies were equal to those catalyzed by the Fe3+. The ionic composition of the ROC solution had an inhibitory effect on the PR oxidation, whereas increased residence time improved it up to 87% at a residence time of 88 min. Overall, the study highlights the potential of heterogeneous Fenton-like processes catalyzed by Fh in a continuous mode of operation.
Therapeutic Potential of Gut Microbiota in Child Health
Authors: Bhattacharjee Ratnadeep , Pathak Kalyani , Das Jyotirmoy , Bordoloi Smita , Pathak Manash Pratim , Barbhuiya Pervej Alom , Saikia Riya
Published: May 2023

Gut or intestinal microbiota inhabit our body and are well nurtured by the body’s ambiance of its preference. Gut microorganisms include bacteria, archaea, and fungi that primarily inhabit the digestive tracts of animals. Bacteria like Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 have been studied on a wide scale for their potential therapeutic applications. These bacteria are used as probiotics, most often as dietary supplements. They increase the population of the gut microbiota required for normal metabolic activities of the body. Recently, efforts have been made to analyze the effects of these probiotics and gut microbiota in the treatment of various diseases in children. In recent years, research has been conducted to investigate the effects of probiotics and microbiota in the gut on the prevention and treatment of a wide range of childhood disorders. Studies have been carried out to investigate the gut microbiota's effects on the function of beta cells in children recently diagnosed with type 1 diabetes. In this review article, a few applications and research of microbiota on children have been highlighted.
Depression and Its Impact on Various Aspects of Life - A
Narrative Review
Authors: Balatif Ridwan , Mawadhani Sukma Alshafiera Azayyana
Published: May 2023

Depression is a mental disorder that affects 279 million people. Patients with depression
will not only have an impact on themselves but can also have an impact on others.
Provide an overview of the impact of depression on health workers, workers, students and patients,
as well as the prevention of depression. Data on the impact of depression and its
prevention using the Google Scholar and Pubmed search engine. Depression in healthcare
workers can affect the occurrence of misdiagnosis of a patient's disease, reduce the quality of
service, and increase the risk of suicide. Depression in other workers can result in lost
productivity and income, absenteeism, presenteeism, and accidents in the workplace.
Depression in students causes decreased student achievement, difficulties concentrating and
social interactions, and absenteeism. In patients with physical illness, depression can increase
the risk of mortality, re-hospitalization, higher costs, poor treatment adherence, and lost followup.
Depression prevention can help lower the risk of depression by up to 21%. This prevention
must be done as early as possible and starts from the scope of prevention at the family level.
Then this prevention can be done individually, especially for those with a high risk of
experiencing depression. The last prevention is universal prevention (population) which can be
started by educating the community. Depression can happen to anyone and will have a
detrimental impact on themselves and others. Prevention of depression should be done as early
as possible to prevent the impacts of depression.
Research on the Construction of Social support System Framework of Sports Service for the Aged in the New Era
Authors: Faze Liang , Ruilian Nie , Liang Zhang , Shirong Zhang
Published: May 2023

Through the documents, logic analysis and other methods of the study of the sports service social support system for the elderly in our country, the paper thinks that the sports service social support system for the elderly refers to by the government, social organizations or individuals through the formal and informal way, for the elderly sports services to provide social support, according to a certain order and contact formed the whole. Relevant responsibility subjects cover the government, communities, sports non-profit organizations, social workers, volunteer service teams. They mainly include formal social support system, informal social support system, professional social support system and community support system. In the future, philosophy reform should be adopted as soon as possible to guide the formulation of relevant policies, and on the basis of giving full play to the leading role of the government, a social support system for sports services for the elderly with Chinese characteristics should be constructed. Through multiple cooperation, an effective supply of sports services for the elderly in China should be realized.
Visualising Path Finding Algorithms Application Development and Implementing
Authors: G B Ujwal
Published: May 2023

Abstract: The Dijkstra algorithm, A* Search, Greedy Best-first Search, Swarm Search, Breadth-first, and Depth-first Search are some of the common algorithms used today. The pathfinding algorithm is used in this study to provide an overview of algorithms and how they are implemented. The user will also learn more about how different algorithms and programming in general work. Knowing these tactics will give them a fundamental understanding of how to create different navigational tools. The visualizer is a grid page containing a "start node" and a "end node." In order to enhance the overall picture and better understand how these pathfinding algorithms deal with our everyday problems, the spectator can add new characteristics like a maze, walls, and weights. To build a visualizer, a programmer needs a solid grasp of front-end programming languages and pathfinding techniques.
Multiple Disease Prediction System
Authors: Saxena Mridul Ishan
Published: May 2023

Abstract: Artificial Intelligence and machine learning is having big impact on Today’s World in various field and we can find AI everywhere. One of the major industry health sectors generates large amount of patient data that can be processed in various form and help to improve patient health. So, with the help Artificial Intelligence and machine learning we have created prediction system that can detect disease at a time. There are many existing systems with less disease prediction, low accuracy and after prediction there is not solution for a person to improve their health status. Low accuracy model can create serious issue with patient minds which can create more problems. We have taken dataset of Parkinson, heart, Diabetes, Breast Cancer. The user will enter various parameter of the disease and the system will configure and tell patient’s health status. After knowing the result if patient is suffering from disease, he/she can talk to our chatbot for advice
Chronic Kidney Disease Prediction Using Machine Learning
Authors: More Rohit
Published: May 2023

Abstract: Chronic kidney disease (CKD) is a life-threatening condition that can be difficult to diagnose early because there are no symptoms. The purpose of the proposed study is to develop and validate a predictive model for the prediction of chronic kidney disease. Machine learning algorithms are often used in medicine to predict and classify diseases. Medical records are often skewed. Chronic Kidney Disease (CKD) or chronic renal disease has become a major issue with a steady growth rate. A person can only survive without kidneys for an average of 18 days, which makes a huge demand for a kidney transplants and Dialysis. It is important to have effective methods for the early prediction of CKD. Machine learning methods are effective in CKD prediction. This work proposes a workflow to predict CKD status based on clinical data, incorporating data prepossessing, a missing value handling method with collaborative filtering and attribute selection. The extra tree classifier and random forest classifier are shown to result in the highest accuracy and minimal bias to the attributes. The project also considers the practical aspects of data collection and highlights the importance of incorporating domain knowledge when using machine learning for CKD status prediction.
Moving Object Detection using Intelligent Spectaculars
Authors: Chaudhari Nachiket
Published: May 2023

Abstract: Moving Object detection systems are used to identify and locate objects in images or videos. When used spectacles, an object detection system can allow the user to see information about the objects in their field of view. This can be useful in a variety of applications, such as helping blind people navigate their environment, or providing augmented reality information to workers. Region-based Convolutional Neural Networks (RCNN) is a type of machine learning model that is commonly used for object detection. The RCNN model first uses a convolutional neural network (CNN) to extract features from the input image, and then applies a region proposal algorithm to identify potential object regions in the image. These regions are then fed into a second CNN, which classifies the regions as objects or background. The RCNN model has been shown to be effective at detecting a wide range of objects in images and videos.
A Review on Fake News Detection
Authors: Bandal Adwait , Rane Tushar
Published: May 2023

Abstract: The widespread increase of fake news, generated by both humans and machines, has negative impacts on both society and individuals, politically and socially. The fast-paced nature of social networks makes it difficult to promptly evaluate the reliability of news. Hence, there is a growing need for automated tools to detect fake news. Compared to traditional machine learning techniques, deep learning-based approaches have shown higher accuracy in detecting fake news. Attention and Bidirectional Encoder Representations for Transformers are some of the emerging deep learning-based methods used for this task. A hybrid Neural Network architecture, which combines CNN and LSTM, is also used along with two different dimensionality reduction techniques, PCA and Chi-Square. These techniques are compared with regular ML techniques such as Decision Tree, logistic Regression, K Nearest Neighbor, Random Forest, Support Vector Machine, and Naive Bayes, as well as RNN and LSTM, in terms of parameters like F1-score and accuracy. The goal is to identify the best approach for detecting fake news.
Imperceptible Technique to Secure Digital Audio Signals while Attaining Trade-Off among the Parameter of Magic Triangle
Authors: Dwivedi Asheesh Kumar
Published: May 2023

Abstract: This paper outlines an audio encryption method that is used during audio compression. Security for the multimedia data is provided by encryption methods. Here, audio encryption is a method used to communicate secret information by subtly altering an audio stream. It is a technique that guarantees secure data transfer between parties that often interact online. Here, we offer a fresh method for dealing with issues raised by audio encryption's substitution mechanism. We employ an enhanced RSA encryption technique, which is incredibly difficult to crack, to encrypt messages in the first level of protection. The encrypted message bits are embedded into random LSB layers to boost robustness against purposeful assaults, in which the hackers constantly attempt to reveal the hidden message, as well as some inadvertent attacks, like noise addition. Here, GA operators are utilised to lessen distortion. The major goal of this work is to propose a good, effective way for hiding data from hackers and sending it to the target in a safer manner by maintaining randomization in message bit insertion into audio data.
Smart Landmine and Restraining Shoes
Authors: Pandey Prakhar
Published: May 2023

Abstract: The smart landmine and restraining shoes project is an innovative solution to reduce the risk of accidental detonation of landmines. The project involves the use of an esp32 module and an RFID tag embedded in a special shoe. When the shoe with the RFID tag is placed on the landmine, it acts as a safety mechanism preventing the mine from being triggered. This technology ensures that the shoes do not trigger the landmines when army personnel steps on them. However, if a terrorist step on the shoe, the RFID tag is detected, causing the landmine to detonate and neutralize the threat.
Aplicación del periodismo abierto como estrategia comunicativa contra la desinformación
Authors: Renedo Farpón Cristina
Published: May 2023

La desinformación ha adquirido una gran relevancia en los últimos años, lo que ha propiciado el surgimiento de proyectos periodísticos especializados en la verificación de contenidos. Este tipo de proyectos trabajan con una metodología que determinan redes internacionales de fact-checkers. En el contexto de estas metodologías de trabajo, el periodismo abierto aplica mecanismos que fomentan la transparencia y la participación en las rutinas profesionales y que pueden resultar beneficiosos para el desarrollo de estas iniciativas verificadoras. En esta investigación se estudian dos iniciativas pioneras en España en verificación, Newtral y Maldita.es, con un análisis de contenido de sus plataformas y entrevistas en profundidad a sus responsables, con el objetivo de comprobar el nivel de aplicación del periodismo abierto en sus rutinas de trabajo, así como evaluar las posibilidades de esta corriente para favorecer la educación mediática y mejorar la producción de contenido periodístico en un contexto de desinformación.
Comunicación interpersonal en la práctica clínica. Experiencia de aprendizaje en un grupo de estudiantes de odontología
Authors: Kweksilber Carola , Todeschini Federico
Published: May 2023

La comunicación interpersonal en la práctica clínica afecta la satisfacción de los pacientes, los resultados clínicos y el bienestar del personal de la salud. Sin embargo, la necesidad de incorporar habilidades de comunicación en la formación del personal de la salud es un problema sin resolver. Se presenta un estudio de caso con metodología cualitativa, que tiene como objetivos comprender los desafíos de un grupo de estudiantes de Odontología para gestionar la comunicación con los pacientes, así como conocer sus percepciones respecto a una primera experiencia de formación en habilidades de comunicación interpersonal. Los datos son recolectados mediante observación participante, narraciones y entrevistas en profundidad, y procesados mediante análisis de contenido. Los desafíos de los estudiantes incluyen sostener el encuadre, manejar la empatía y persuadir a los pacientes para cumplir el tratamiento. Relatan cambios en la comunicación con los pacientes, que adjudican a su participación en la experiencia formativa.
Intervenciones de competencias socioemocionales en adolescentes con diagnóstico del espectro autista: una revisión sistemática
Authors: Contreras Saavedra Carolina Noemí , Sáez-Delgado Fabiola , Sepúlveda López Felipe , Ramos-Huenteo Valentina
Published: May 2023

Las competencias socioemocionales en las escuelas son un factor protector de la salud mental, mejoran los resultados académicos y el clima escolar. Sin embargo, desconocemos el efecto en adolescentes con autismo, quienes tienen dificultades específicas en la comunicación e interacción social. El objetivo de esta revisión es indagar la literatura sobre intervenciones para desarrollar competencias socioemocionales en adolescentes dentro del espectro autista, sus características y efectividad en un contexto de desafíos para una educación inclusiva. Se utilizó el método PRISMA, que resultó en siete artículos seleccionados de 158 textos examinados de cuatro bases de datos. Se evidencia una predominancia de un tamaño del efecto pequeño, muestras inferiores a 30, una frecuencia de dos sesiones por semana por períodos de hasta 15 semanas aproximadamente.
Proximidade geográfica ainda importa para inovação? Considerações baseadas na interação universidade-empresa em contexto periférico
Authors: Fernandes Ana Cristina de Almeida , Souza Bruno Campello de , Silva Alexandre Stamford da , Lima João Policarpo Rodrigues
Published: May 2023

Interações entre universidades e empresas são essenciais para sistemas de inovação, com o processo catalisado pela proximidade entre esses atores em diferentes dimensões (cognitiva, organizacional, social, institucional e geográfica). O presente trabalho pretende promover a compreensão da importância da proximidade geográfica para interações universidade-empresa em um momento histórico específico da formação socioeconômica brasileira, quando se observavam a construção de um arcabouço institucional favorável à inovação periférica e o avanço das tecnologias de informação e comunicação que dispensariam a colocalização e o contato face a face em processos de aprendizagem coletiva. A aplicação de análises de Regressão Linear Múltipla e da Smallest Space Analysis (SSA) a uma base de dados obtida em 2008, resultante de uma survey extensiva, permitiu observar que, associada à dimensão cognitiva, a proximidade geográfica prevalece em interações para inovação em contextos periféricos.
Perlindungan Hak Anak Pra Isbat Nikah ditinjau dari Hukum Positif (Studi Kasus Putusan Mahkamah Syar’iyah Nomor 40/Pdt.P/2021/MS.Bna)
Authors: M. Yunus Fakhrurrazi , Dwi Oktavia
Published: May 2023

Perlindungan anak sulit dilakukan tanpa adanya pencatatan resmi tentang kelahiran anak tersebut, karena orang tuanya menikah tanpa ada catatan nikah resmi dalam peraturan republik Indonesia, dalam artian belum dilakukan pencatatan di KUA, namun pernikahan tersebut sah menurut pandangan agama dikarenakan telah memenuhi rukun dan syarat nikah sesuai dengan tuntunan syari’at.Rumusan masalah yang akan ditinjau adalah melihat bagaimana perlindungan anak pra istbat nikah jika ditinjau melalui hukum positif pada putusan mahkamah syar’iyah Nomor 40/Pdt.P/2021/MS.Bna dan bagaimana metode penemuan hukum hakim terhadap dikabulkannya permohonan pengesahan nasab anak dari pasangan yang belum isbat nikah, sedangkan yang menjadi tujuannya adalah untuk mengetahui perlindungan anak pra itsbat nikah jika ditinjau melalui hukum positif dan mengetahui metode hukum hakim dalam mengabulkan pengesahan nasab ana dari pasangan pra itsbat nikah. Penelitian ini menggunakan metode kualitatif dengan pendekatan yuridis normatif. Adapun teknik pengumpulan data melalui kepustakaan (library research), analisis data dengan cara deskriptif normatif. Hasil penelitian menunjukkan bahwa Setiap anak berhak atas menerima perlindungan dan mendapatkan haknya salah satu haknya tersebut adalah identitas diri dan status kewarganegaraan. Identitas diri seorang anak harus diberikan sejak kelahirannya, yang dituangkan dalam akta kelahiran (vide Pasal 5, Pasal 7, ayat (1)  dan Pasal 27 ayat (1) dan (2) Undang-Undang Nomor 23 Tahun 2002 Tentang Perlindungan Anak. Metode penemuan hukum hakim ada tiga; merujuk pada doktrin hukum Islam yang termuat dalam kitab Al Fiqhu Al Islami Wa Adillatuhu, merujuk pada ketentuan Pasal 55 Ayat (3) Undang-Undang Nomor 1 Tahun 1974 tentang perkawinan juncto Pasal 103 Ayat (3) Kompilasi Hukum Islam di Indonesia dan pada Pasal 47 Undang-Undang Nomor 23 Tahun 2006 tentang Administrasi Kependudukan.
Não foi só ensinar: alterações osteomusculares em docentes no sistema home office de ensino
Authors: Geller Iago Vinicios , Ilkiu Giovana Simas de Melo , Amarantes Willian Amauri , Ruski Marcos Vinicius , Gonzales Daniel Alberto
Published: May 2023

Covid-19 led to changes in face-to-face education, replaced by remote teaching, leading teachers to health consequences. The pandemic may have generated new musculoskeletal changes in teachers or intensified pre-existing ones. The objective was to evaluate the time during which professors worked remotely, analyzing the incidence of musculoskeletal alterations. Data collection took place in 2021 using Google forms. There were 92 responses, of those teaching between one and two years (76.1%), with more than 60% staying for more than six hours in front of the computer screen, 96.7% of professors have some type of musculoskeletal pain, and 33.7% claim that the pain started after they started working in front of the computer. The main regions with pain are the cervical area, houlders, and lumbar area. Inadequate posture combined with non-ergonomic furniture affect postural muscles, leading to fatigue and pain. The change in the way of working led to a biopsychosocial imbalance and shall be further investigated.
Market competition determinants of consumer behavior
Authors: Memeti Karemani Selbije , Memeti Era
Published: May 2023

The purpose of this work is the analysis of consumer behavior, as well as the analysis of economic, social, cultural, and psychological influences on consumers when choosing and purchasing special products. According to Schiffman and Kanuk (2009), consumer behavior is the behavior that consumers manifest during the search, purchase, use, evaluation, and disposal of products and services that they expect to satisfy their needs, and the purchase includes a psychological process according to which consumers who have identified their needs, collect information, and find the way how to fulfill their needs and desires (Kurtz & Boone, 2009). During the research, comparative economic analysis methods and statistical methods will be used. As an instrument, the multifactor leadership questionnaire (MLQ) was used as a psychometric method (Bass & Avolio, 2000), and with the psychographic analysis that measures the lifestyle. The results of the research will be very useful because they will help further research on this issue. As many times as research on this topic are done, we will see that the results are different because consumer behavior is very complex and changing, therefore continuous study is required, which will always include all the changes that are made in the environment.
Ranolazine reduces oxidative damage and improves kidney function in cisplatin-induced nephrotoxicity
Authors: Tanriverdi Lokman Hekim , Goncu Hatice , Gunata Mehmet , Beytur Ali , Vardi Nigar , Cigremis Yilmaz , Parlakpinar Hakan
Published: May 2023

Cisplatin (CIS)-induced nephrotoxicity is associated with oxidative
stress, apoptosis, inflammation, and fibrogenesis. In this study, we
investigated the therapeutic effects of ranolazine (RAN), a current
antianginal drug known to experimentally reduce oxidative damage in
CIS-induced nephrotoxicity. We randomly assigned thirty-two Sprague
Dawley rats to one of four groups (Control, CIS, CIS+RAN, and RAN+CIS).
We evaluated kidney function parameters including blood urea nitrogen
(BUN), creatinine (Cre), electrolytes, and albumin, as well as tissue
biochemical parameters including malondialdehyde (MDA) and antioxidant
enzymes. Histopathological parameters were also assessed. We observed a
significant increase in BUN and Cre values in the CIS group compared to
the control group (p<0.05). However, there was a significant
decrease in BUN values (p<0.05) in the CIS+RAN and RAN+CIS
groups compared to the CIS group. In contrast, the decrease in Cre
values did not reach statistical significance (p>0.05), and
serum electrolytes were comparable among groups. Furthermore, a
statistically significant increase in albumin levels was observed in the
CIS+RAN group compared to the CIS group (p<0.05). MDA levels
were significantly decreased in the CIS+RAN group compared to the CIS
group, indicating the antioxidant activity of RAN (p<0.05).
Histopathological analysis revealed that necrosis and dilatation in
epithelial cells of cortical and medullary tubules were more prominent
in the CIS group (p<0.0001). However, in the RAN+CIS group,
the histopathological changes observed in the CIS group were found to be
significantly reduced (p<0.0001). Degenerative changes in
tubules were observed in the CIS+RAN group (p>0.05). Our
findings suggest that the beneficial effects of RAN on CIS-induced
nephrotoxicity may be related to its antioxidant activity.
Investigation of Biochemical Blood Parameters of COVID-19 Patients Short (running) title: Biochemical Blood Parameters of COVID-19 Patients
Authors: ERİTEN Semih
Published: May 2023

Objectives: In this study, it was aimed to investigate the effect of
biochemical blood values on the course of the disease. Material and
Methods: This is a retrospective study. For the treatment of COVID-19,
clinical features and biochemical test parameters of 243 patients who
applied to Malatya Training and Research Hospital in Malatya province of
Turkey between 03 March and 31 December 2021 were used. Results: In the
regression analysis performed in patients with Covid, glucose, urea,
ALP, LDH, albumin, calcium and potassium levels were found to be
effective on the severity of the disease. Conclusion: Biochemical
parameters can be used as clinical findings to predict the diagnosis and
course of COVID-19.
Filantropia de risco nas redes estaduais de ensino brasileiras
Authors: Adrião Theresa Maria de Freitas , Borghi Raquel Fontes
Published: May 2023

Este artigo integra pesquisa interinstitucional que mapeou e analisou estratégias de privatização da educação básica nas redes estaduais de educação pública do Brasil. O objetivo é apresentar a incidência do Instituto Ayrton Senna (IAS) no conjunto das redes e analisar este ator privado e seu modus operandi associado ao filantrocapitalismo. Foram levantados e tratados dados sobre a privatização da educação básica coletados junto às páginas institucionais de governos e organizações privadas. Os resultados indicam que o IAS incidiu prioritariamente em redes estaduais da Região Nordeste e Centro-oeste, no ensino fundamental e nos currículos dessas redes.
Cesarean delivery under neuraxial anesthesia in a patient with a liver transplant
Authors: Krusic Slavica , Pejcic Nada , Stojanovic-Tasic Mirjana , Damnjanovic Dijana , Abir Gillian
Published: May 2023

Introduction. Improved outcomes after liver transplantation contribute to a successful pregnancy and delivery in transplant recipients. Anesthesiology teams face challenges when providing perioperative care to patients who have a liver transplant and undergo cesarean delivery, which include: an increased rate of cesarean delivery, a high risk of infection, and a high risk of interaction between immunosuppressant and anesthetic drugs. Case outline. We report the case of a 28-year-old patient with a liver transplant (from a live donor) who underwent elective cesarean delivery under neuraxial anesthesia. Appropriate anesthetic management is critical to ensure optimal perioperative maternal and fetal outcomes. Cardiovascular stability after neuraxial anesthesia was maintained with adequate perioperative intravenous fluid management and early vasopressor(s) administration to preserve hepatic perfusion. Multimodal postoperative analgesia was administered; however, caution is required when prescribing drugs that have the potential for hepatic and renal side effects. Conclusion. Multidisciplinary team evaluation, planning, and preparation are vital for optimizing safe care and delivery of pregnant patients with transplanted organs.