bluuebunny/crossref_metadata_2025 huggingface dataset:
Laparoscopic approach for renal denervation: an experimental study on animals
Authors: Bashta D. I. , Vilenskiy L. I. , Krivosheev Yu. S. , Modnikov K. V. , Modnikova M. A. , Romanov A. B.
Published: October 2023

Aim. To study the efficacy and safety of laparoscopic mechanical renal denervation.

Methods. Thirty sheep with mean weight 92.3±2.1 kg were divided in 2 groups: control group (group I, n=15) and mechanical laparoscopic renal denervation group (group II, n=15). The follow-up period was 6 months. The following parameters were assessed: blood pressure in response to high-frequency electrical intraluminal stimulation, creatinine, blood urea nitrogen test (BUN), damage to the renal arteries according to the result of angiography, the degree of destruction of nerve fibers according to histological examination.

Results. All animals were alive during the entire observation period. The creatinine and BUN were within the normal ranges during the observation period. Angiography of the renal arteries did not reveal iatrogenic stenotic lesions. After 6 months in group 2 there was hypertensive response of blood pressure to high-frequency electrical stimulation (in-creased systolic blood pressure ∆70.27±5.31 (p>0.005), diastolic blood pressure ∆49.87±6.05 (p>0.005)). After 6 months, the animals were euthonised, further histological examination was completed. Histological examination: in the group II, there was swelling and vacuolization of the nerve fiber without signs of demyelination.

Conclusions. Laparoscopic mechanical renal denervation is a safe technique. However, the hypotensive effect is short-term.
Left ventricle mechanical dispersion is a new universal marker of malignant ventricular tachyarrhythmias in patients with structural heart disease
Authors: Guseva E. V. , Shlevkov N. B. , Tarasovskiy G. S. , Shitov V. N. , Salami H. F. , Kiktev V. G. , Saidova M. A.
Published: October 2023

Aim. To evaluate the possibility to use parameters of global, segmental longitudinal left ventricle (LV) strain and LV mechanical dispersion (MD) as new possible markers of malignant ventricular tachyarrhythmias (MVT) in patients with structural heart disease and reduced and intermediate LV ejection fraction (EF).

Methods. The study included 113 patients (105 male, age 66 [59;73] year) with ischemic (n=89) or non-ischemic (n=24) dilated cardiomyopathy and LVEF<50%, implanted cardioverter-defibrillators, cardiac resynchronization therapy devices-defibrillators, pacemakers or documented MVT. All patients underwent transthoracic echocardiography with an assessment of speckle-tracking echocardiography parameters (global and segmental longitudinal LV strain, LV MD). Comparative univariate and ROC-analyses were performed between patients with and without MVT separately for patients with LVEF <35% (n=60) and LVEF 36-50% (n=53) LVEF.

Results. The group of patients with LVEF ≤35% with MVT (n=30) was characterized by lower values of longitudinal strain of the basal segment of the LV septum wall (-5[-6,5;-0,5] vs -6,8[-11;-4.4], р=0,01, respectively) and the middle segment of the LV inferior wall (-3[-6;2] vs -6[-9;-1,5], р=0,04, respectively). The group of patients with LVEF 36-50% with MVT (n=33) was distinguished by a large value of LV end-diastolic volume (166,5[146,3;193] vs 156[133,8;165,5], р=0,04, respectively). The greater values of LV MD were noted in both groups of patients with MVT. The optimal cut-off value of LV MD was 120 ms (area under the ROC curve 0.817, sensitivity-73,3%, specificity-80%) for patients with LVEF≤35%, and 90 ms (area under the ROC curve 0.761, sensitivity-72.7%, specificity-75%) for patients with LVEF 36-50%.

Conclusion. Speckle-tracking echocardiography parameters may serve as additional markers of increased risk of MVT in patients with structural heart disease and impaired LVEF. Only LV MD is useful for risk stratification of MVT in patients with either reduced or intermediate LVEF.
FEN EĞİTİMİNDE OKUL DIŞI ÖĞRENME ORTAMLARINA YÖNELİK ETKİNLİK PLANI OLUŞTURMA SÜRECİ VE ÖRNEK ETKİNLİKLER
Authors: TUNCAY YÜKSEL Büşra , KUTRU Çağla
Published: October 2023

Yapılan araştırmalar okul dışı öğrenme ortamlarının fen eğitimi açısından önemli olduğunu göstermekle beraber okul dışı öğrenme etkinliklerinin sınıf yönetimindeki zorluklar veya ders materyallerinin yetersizliği gibi birtakım sebeplerden dolayı öğretmenler tarafından ders süreçlerinde çok fazla tercih edilmediğini göstermektedir. Bu bakımdan, okul dışı öğrenme etkinliklerine yönelik öğretmenlere ve öğretmen adaylarına yol gösterici materyallerin sunulmasının faydalı olacağı birçok araştırmacı tarafından savunulmaktadır. Bu durumdan hareketle, bu çalışmada okul dışı öğrenme ortamlarının planlamasına ilişkin etkinlik öncesi, etkinlik sırası ve etkinlik sonrası olmak üzere, yapılması gerekenlere uygun biçimde hazırlanmış olan Okul Dışı Öğrenme Etkinlik Planı şablonu oluşturulmuştur. Ek olarak, bu plan şablonuna göre hazırlanmış olan iki adet okul dışı öğrenme etkinliği (1- Oyun parkları etkinliği, 2- Milli parklar etkinliği) okuyuculara sunulmuştur. Okul Dışı Öğrenme Etkinlik Planı şablonunun hazırlanması sürecinde tasarım-temelli araştırma yöntemi kullanılmıştır. Hazırlanan ilk etkinlik güncel Fen Bilimleri dersi öğretim programında yer alan 5. sınıf İnsan ve Çevre ünitesindeki “F.5.6.2.1. İnsan ve çevre arasındaki etkileşimin önemini ifade eder.” kazanımına yönelik hazırlanmıştır. Hazırlanan etkinlik Öğretmenlik Uygulaması-II dersi kapsamında fen bilgisi öğretmen adayları tarafından 5. sınıfta öğrenimine devam eden 20 öğrenciye uygulanmış ve öğrencilerden etkinlik hakkında geri dönütler alınmıştır. Öğrencilerden alınan geri dönütler ve etkinlik sırasında alınan öğretmen adayı notları bütüncül bir şekilde değerlendirilerek ikinci etkinlik oluşturulmuştur. İkinci etkinlik güncel fen bilimleri dersi öğretim programında yer alan ve 5. sınıf Canlılar Dünyası ünitesindeki “F.5.2.1.1. Canlılara örnekler vererek benzerlik ve farklılıklarına göre sınıflandırır.” kazanımına yönelik hazırlanmıştır. Okul Dışı Öğrenme Etkinlik Planı şablonunun ve bu şablonun içeriğine uygun olarak hazırlanan etkinlik planlarının derslerinde okul dışı öğrenme ortamlarından yararlanmak isteyen öğretmen adaylarına ve öğretmenlere fayda sağlayacağı düşünülmektedir. Ayrıca çalışmanın okul dışı öğrenme ortamlarına yönelik etkinlik hazırlama konusunda yapılacak araştırmalara örnek teşkil edebileceği düşünülmektedir. Dolayısıyla, çalışmanın fen eğitiminde okul dışı öğrenme ortamlarından daha fazla yararlanılmasına katkı sağlayacağı öngörülmektedir.
Управляемая синхронизация в сетях нейронов Хиндмарша-Роуза
Authors:   , Semenov Danila
Published: October 2023

Диссертационная работа посвящена управлению синхронизацией в сетях математических моделей нейронов Хиндмарша-Роуза. Возможность управления синхронизацией в динамических сетях, состоящих из сложных систем, породила новую междисциплинарную область исследований. В последние десятилетия эта область быстро развивается. В сетях биологических нейронов немаловажную роль играют адаптивность и задержка распространения потенциала действия между нейронами. Например, адаптивность позволяет описать такое свойство нейронных сетей, как нейропластичность, а задержки распространения сигнала от одного нейрона к другому напрямую влияют на наличие или отсутствие синхронизации между нейронами. Однако, в большинстве работ адаптивность и наличие задержек распространения потенциала действия не учитываются ввиду сложности математических методов для анализа таких сетей. В настоящей работе предпринята попытка решения приведенных выше проблем методами адаптивной теории управления. В качестве исследуемой модели нейронной популяции выбрана спайковая нейронная сеть Хиндмарша-Роуза.
PERFIL DOS GASTOS DOS MUNICÍPIOS BRASILEIROS COM GESTÃO AMBIENTAL ENTRE 2004 E 2020
Authors: Macedo Reginaldo Morais de , Theóphilo Carlos Renato , Patta Marilée , Santos Júnior Ismael Mendes dos
Published: October 2023

O objetivo deste trabalho foi analisar o perfil de gastos dos municípios brasileiros com gestão ambiental no período de 2004 a 2020 a partir da aplicação de variáveis econômicas e geográficas. A pesquisa é de abordagem quantitativa, descritiva e documental. Os dados foram disponibilizados pela Secretaria do Tesouro Nacional (STN), tratados e atualizados pela inflação do período (IPC-A), sendo analisados todos os municípios brasileiros. Os resultados apontam que os gastos ambientais (GA) (R$ 81,07 bilhões) apresentaram crescimento em valores absolutos (154,25%) e per capita (181,89%), embora ainda sejam pouco representativos frente às despesas orçamentárias (0,86%) e ao PIB (0,07%), estando fortemente concentrados (70%) em poucos municípios (2,78%), regiões geográficas (Sul e Sudeste), unidades federativas (RS, MG, PR e SP) e biomas (Mata Atlântica). São Paulo (GA absolutos), Rio das Ostras (GA per capita), Vitória (GA por área em km2) e Jaguaraçu (GA pelas despesas totais) destacaram-se nas análises. As funções mais proeminentes entre os municípios com gastos frequentes foram Preservação Ambiental, Outros Gastos/Não documentados e Controle Ambiental. Sugere-se novas pesquisas.
Resonant tunneling and quantum interference of a two-spin system in silicon tunnel FETs
Authors: Moriyama Satoshi , Mori Takahiro , Ono Keiji
Published: October 2023

We investigated the resonant tunneling of a two-spin system through the double quantum dots in Al–N-implanted silicon tunnel FETs (TFETs) by electrical-transport measurements and Landau–Zener–Stückelberg–Majorana interferometry with and without magnetic fields. Our experimental results revealed the coexistence of spin-conserving and spin-flip tunneling channels in the two-spin system in non-zero magnetic fields. Additionally, we obtained the spin-conserving/spin-flip tunneling rates of the two-spin system through the double quantum dots in the TFET. These findings will improve our understanding of the two-spin system in silicon TFET qubits and may facilitate the coherent control of quantum states through all-electric manipulation.
RF operation of AlN/Al0.25Ga0.75N/AlN HEMTs with f

T
/f
max of 67/166 GHz
Authors: Kim Eungkyun , Singhal Jashan , Hickman Austin , Li Lei , Chaudhuri Reet , Cho Yongjin , Hwang James C. M. , Jena Debdeep , Xing Huili Grace
Published: October 2023

We report on highly-scaled Al0.25Ga0.75N channel high electron mobility transistors. Regrown ohmic contacts covering the sidewall of the compressively strained Al0.25Ga0.75N channel exhibited a low contact resistance of R
c = 0.23 Ω · mm. Scaled devices with a T-shaped gate showed record high speed for any AlGaN-based transistors, f
T/f
max = 67/166 GHz, while simultaneously achieving high average breakdown field exceeding 2 MV cm−1. The load-pull measurements performed at 10 GHz revealed a 20% peak power added efficiency with an output power density of 2 W mm−1, which is mainly limited by the RF dispersion.
Problems of qualification of crimes, related to illegal entry into the home
Authors: Kosolapova E. N.
Published: October 2023

Given the large number of crimes involving illegal entry into the home, it seems relevant to consider the application of the qualifying feature “illegal entry into the home” in such crimes as theft, robbery, robbery. The purpose of the study is to analyze judicial practice and scientific literature to establish how the application of the qualifying feature “illegal entry into the home” in a number of crimes (in the commission of theft, robbery, robbery) occurs. The author used the methods of analysis and synthesis. As a result of the study it was found that the courts, when applying the qualifying feature “illegal entry into the home” in such crimes as theft, robbery, robbery, pay attention to the initial intent to commit a crime involving illegal entry into the home. Scientific novelty consists in the fact that the error in the qualification of the crime by the bodies of preliminary investigation is revealed. It is important for the law enforcer to determine the initial intent to commit a crime associated with illegal entry into a dwelling in order to qualify the act as theft (robbery, robbery) with illegal entry into a dwelling. In the author’s opinion, despite the fact that the Criminal Code of the Russian Federation contains the concepts of “dwelling”, “storage” and “premises” fixed by law, in practice there may be problems associated with the delimitation of these concepts. To avoid this situation, according to the author’s position, the state should pay more attention to the issue of advanced training of preliminary investigation officers (including seminars).
The possibility of integration between Six Sigma approach and Balanced Scorecard of Palestinian Shareholding Industrial companies
Authors: AlKababji Majdy
Published: October 2023

هدفت الدراسة التعرّف إلى إمكانية التكامل بين منهج سيجما ستة وبطاقة الأداء المتوازن في الشركات الصّناعية المساهمة العامة الفلسطينية, وذلك من خلال التعرّف على العلاقة بين منهج سيجما ستة وأبعاد بطاقة الأداء المتوازن المتمثّلة في (بُعد العملاء, البُعد المالي, بُعد التعلّم والنموّ, بُعد العمليات الداخلية, البُعد الاجتماعيّ),إضافة إلى التعرّف على الصعوبات والمعيقات التي تواجه تطبيق التكامل. ومن أجل تحقيق أهداف الدراسة, تمّ استخدام المنهج الوصفيّ التحليليّ, من خلال تصميم استبانة وُزِّعت على عينة الدراسة المتمثلة في العاملين الإداريين في الشّركات الصّناعية المساهمة العامة المدرجة في بورصة فلسطين, والتي يبلغ عددها (13) شركة. وقد توصّلت نتائج الدراسة إلى أنّ الشركات الصّناعية المساهمة العامة الفلسطينية تطبق مدخل التكامل عبر تركيز الشركات على الاستفادة من المنافع المتولّدة من التكامل بين منهج سيجما ستة وبطاقة الأداء المتوازن, ووجود أثر وعلاقة طردية بين منهج سيجما ستة وأبعاد بطاقة الأداء المتوازن, وكما أظهرت النتائج أنّ هناك صعوباتٍ ومعيقاتٍ تواجه الشركات عند تطبيق التكامل بين منهج سيجما ستة وبطاقة الأداء المتوازن. وقد قدم الباحثان مجموعةً من التّوصيات, من أهمّها: ضرورة التوجّه نحو إعداد الكوادر المهنية المدرّبة تدريبًا معتمِدًا على تطبيق منهجية سيجما ستة, وكذلك على كيفية التعامل مع بطاقة الأداء المتوازن من أجل الاستجابة للمتغيرات البيئية السريعة.
D-SALMA'S CATALOG SMART EFFECTIVELY INCREASES KNOWLEDGE OF PREGNANT WOMEN IN PREVENTING DENTAL CARIES
Authors: Salmawati Salmawati , Hadisaputro Soeharyo , Sunarjo Lanny , Sutomo Bambang
Published: October 2023

Background: Pregnant women are one of the vulnerable groups to dental caries with a prevalence of 84.7%. During pregnancy, hormonal changes occur characterized by nausea, vomiting and laziness to brush teeth, acidic nature and changes in salivary pH cause dental caries. This condition can result in babies born with low body weight (BBLR), miscarriage, and pre-eclampsia. One of the efforts to increase knowledge in the maintenance of dental and oral health for pregnant women is to do promotion and prevention with educational media D-Salma's Catalog Smart, which is the development of a model of the caries catalog, this media is a picture book equipped with a pen book and in a special design using sensors to facilitate the pen book read and explain the content of the material. Objective: Produce a decent educational model and analyze theeffectiveness of v ity to increase the knowledge of pregnant women in preventing dental caries. Method: Type of R&D research, methode Quasy experiment Pre-Posttest group design (nonequevalent control group design). In the application of the model using a sample of 60 pregnant women divided into 2 intervention groups with the D-Salma's Catalog Smart model and a control group with a booklet. The variables measured are knowledge and OHIS of pregnant women. Data analysis used univariate analysis, bivariate analysis (Paired Sample T-test and Independent Sample T-test) and multivariate analysis with (linear regression).  Results: Model D-Salma's Catalog Smart is validated and feasible to be applied as a medium for dental health education. The results of the effectiveness test increased knowledge from 3.40 to 8.00 (p = 0.000), and decreased the OHIS score from 3.90 to 1.00 (p = 0.000).  Conclusion: The application of D-Salma's catalog smart model is feasible and effective in increasing the knowledge of  pregnant women in preventing dental caries.
“FIDZ-ABCT” MODEL TO IMPROVE CROSS INFECTION PREVENTION ON TOOTH EXTRACTION
Authors: Murad Fidzah Nurfajrina , Fatmasari Diyah , Wiyatini Tri
Published: October 2023

Background: The profession of dental and oral therapist (TGM) has a high risk of disease transmission, so it is important to prevent cross-infection in dental extraction services because they come into direct contact with the patient's body fluids. The description of TGM behavior in Maros Regency in preventing cross infection is not optimal, 50% do not carry out SOPs properly, 63% do not maintain hand hygiene, 50% do not change handscoons and sterile masks every time they change patients. Efforts are needed to increase cross-infection prevention behavior with the "Fidz-ABCT" Model as an educational model based on learning by doing training with the aim of improving TGM behavior in preventing cross-infection during tooth extraction procedures in community health centers. Objective: To prove the effectiveness of implementing the "Fidz-ABCT" educational model in improving TGM behavior towards preventing cross infection during tooth extraction procedures at community health centers. Method: Research and Development research design Quasy Experiment Pre-test and Post-test Control Group Design. The research subjects were TGM, 14 intervention people were given the "Fidz-ABCT" model, 14 control people were given counseling on the PPI guidebook at the community health center. Data collection techniques were interviews, questionnaires, and measuring the number of bacteria on dental extraction tools. Data were processed using the Wilcoxon test and Mann-Whitney test. Results: The "Fidz-ABCT" model is suitable for use in improving TGM behavior in preventing cross-infection during tooth extraction procedures at health centers, expert validation results are 85% and p-value 0.013 (p<0.05). The results of the delta test stated that its implementation was effective in increasing knowledge of intervention (?=5.57) control (?=1.50), attitude of intervention (?=14.21) control (?=5.07), intervention action (?=7, 42) control (?=1.64), effective in reducing the number of bacteria on dental extraction tools (p-value 0.012). Conclusion: The application of the "Fidz-ABCT" educational model is feasible and effective in increasing TGM behavior in preventing cross-infection during tooth extraction procedures at community health centers.
АСПЕКТИ РОЗВИТКУ ВОДНЕВОЇ ЕНЕРГЕТИКИ УКРАЇНИ ЗА РАХУНОК ВИКОРИСТАННЯ ЕНЕРГІЇ ВІД ВІДНОВЛЮВАНИХ ДЖЕРЕЛ
Authors: Рєпкін О. О.
Published: October 2023

Використання зеленого водню відіграє важливу роль у відновленні України, оскільки є одним з ключових напрямів переходу до чистої відновлюваної енергетики. Завдяки впровадженню проєктів у цій сфері Україна та Європейський Союз отримають екологічно стале джерело енергії, переведуть значну частку української економіки на низьковуглецеву основу та забезпечать розвиток пан’європейських водневих мереж. Співпраця з європейськими країнами сприятиме розвитку української енергетичної інфраструктури, створенню нових робочих місць та зниженню впливу на навколишнє середовище. Подальший розвиток галузі відновлюваної енергетики можливий за умови створення регулювальних потужностей, будівництва промислових енергетичних акумулювальних потужностей з метою стабілізації відпуску електроенергії до об’єднаної електричної мережі й формування коректної державної політики. Регулювальні потужності допоможуть вирішити питання надлишку електроенергії в години профіциту на ринку, стабілізувати ситуацію в години дефіциту, відмовитись від імпорту електроенергії з інших країн та сформувати ринок експорту української електроенергії в європейські країни. З урахуванням міжнародної підтримки водень може слугувати необхідним буфером і забезпечити стійкість загальної енергетичної системи України. У цій статті представлено огляд засад для розробки проєктів комплексного використання ВДЕ з метою отримання зеленого водню на території України та перспектив постачання його до загальної Європейської системи.
АНАЛІТИЧНИЙ РОЗРАХУНОК ГЛИБИНИ ПОШИРЕННЯ ТЕМПЕРАТУРНОЇ ХВИЛІ ПРИ ПОБУДОВІ ГЕОТЕРМАЛЬНИХ ТЕПЛОНАСОСНИХ СИСТЕМ
Authors: Морозов Ю. П. , Зур’ян О. В.
Published: October 2023

У процесі вирішення завдань ґрунтового акумулювання й вилучення теплоти з приповерхневих шарів Землі, виникає потреба одержати інформацію щодо глибини добових та річних змін температури в ґрунті, яка визначає шар земної поверхні, що активно взаємодіє з навколоземною атмосферою. У холодну пору року температура в ній знижується, а в теплу – підвищується. Відомо, що ефективність теплонасосної системи залежить як від різниці температур на виході з конденсатора теплового насоса та вході в його випарник, так і від стабільності температури джерела теплової енергії. Температура на вході у випарник теплового насоса визначається температурою ґрунту в місці встановлення колектора теплової енергії. Відомо, що найбільш економічно рентабельною є інсталяція геотермальних теплообмінників, розташованих горизонтально в ґрунті на невеликій глибині, за рахунок менших витрат на земельні роботи та відсутності необхідності буріння глибоких свердловин. Водночас ці системи найвразливіші до перепаду температур, що відбувається в приповерхневих шарах. Тож виникає потреба в дослідженні теплофізичних процесів, що відбуваються в ґрунті під впливом екзогенних факторів. Відомо, що температура ґрунту має добову та річну періодичність. Ступінь нагрівання ґрунту залежить від його теплопровідності, під якою розуміють здатність ґрунту проводити тепло з більш нагрітих шарів у шари менш нагріті. А коливання температури ґрунту може суттєво залежати від рослинного покриву ґрунту, характеру та висоти його протягом року. Разом з тим залишаються недостатньо дослідженими системи теплообмінник–ґрунт, ефективність використання яких безпосередньо залежить від розподілу температури в ґрунті та факторів, які на цей розподіл впливають. Головною особливістю системи добування геотермальної теплової енергії є поєднання технічних і природного елементів таких систем. При цьому природнє джерело теплової енергії перебуває в середовищі, яке малодоступне для спостережень. Метою дослідження є розроблення прикладної методології як сукупності принципів та підходів математичного моделювання на основі запропонованого математичного апарату аналітичного розрахунку глибини поширення температурної хвилі при побудові  геотермальних теплонасосних систем. Основний математичний апарат для опису таких процесів включає в себе диференціальні рівняння, що враховують залежність температури від часу та просторових координат. Мають перспективу подальші дослідження щодо розрахунку можливості застосування сонячної системи для отримання теплової енергії для зменшення девіації температури теплоносія на вході в випарник теплового насоса, що поступає від горизонтального ґрунтового теплообмінника, змонтованого в ґрунті нижче глибин промерзання та вище нейтрального шару температур.
The Dynamic Impact of Economic Growth, Foreign Direct Investment and Infrastructure in Laos
Authors: Bounphone Khammai , Keothephar Keoudone , Srithilat Vilayvanh , Kidoikhammuan Somwang
Published: October 2023

This study examines the dynamic impacts of economic growth, foreign direct investment, and some infrastructure variables in Laos with the time series data from 1995-2020, which have used the Generalized Method of Moments (GMM) and Autoregressive Distributed Lag (ARDL) model approach. The unit root test to check the stationarity of all variables in this study using the Augment Dicky Fuller (ADF) test with considering both level and at first difference. The empirical results of GMM found that the FDI is a major catalyst for economic growth in Laos which has a positive impact and is statistically significant at the level. Similarly, the role of infrastructure variables such as agriculture, industry, and service is the main of the most important indicators in supporting the economic growth in Laos, while telecommunication, electricity, air transport, and trade are positive but insignificant at the level. However, this study also found some variables such as labor, population growth, and life expectancy in support of economic growth which have a strongly positive and significant impact at the level, but the human capital is insignificant at the level. We, therefore, recommend that the government of Laos should attract and sustain more foreign direct investment and increase the infrastructural development to achieve the target of sustainable economic growth in the near future.
Prevalence of Hypothyroidism in Pregnancy in a Tertiary Care Hospital
Authors: Akhter Mahbuba , Shimul Sabiha , Khanum Mahbuba , Haider Rina
Published: October 2023

Introduction: Thyroid disorders are the most common endocrine disorders affecting women of reproductive age. The most frequent thyroid disorder in pregnancy is maternal hypothyroidism. During early pregnancy, the fetus is totally dependent on maternal thyroid hormone supply. Thyroid hormone is critical for fetal brain and intellectual development. Thyroid hormone is also important for some preventable pregnancy complications like anaemia, low birth weight, abruptio placenta, preeclampsia, etc., which pose special risks for the mother and developing fetus. Aim of the study: To assess the prevalence of hypothyroidism in pregnant women and thus ensure appropriate treatment for the wellbeing of the mother and baby. Methods: This prospective obsessional study was conducted on 113 pregnant women at US Bangla Medical College Hospital, Dhaka, Bangladesh, who attended obstetrics outdoors. Women were randomly chosen irrespective of age, parity, residence, and socioeconomic status. Women with multiple pregnancies or having any pre-existing medical disorder were excluded. All women were investigated for TSH along with routine pregnancy tests. All were divided into two groups: normal/euthyroid and abnormal/thyroid disorders, considering their thyroid status. Result: We found the prevalence of thyroid dysfunction in pregnancy was 17.7%, with hypothyroidism being 15.93%, of which 10.62% were subclinical hypothyroidism, 5.31% were cases of overt hypothyroidism, and 1.77% were cases of hyperthyroidism. Conclusion: This study showed an increased prevalence of hypothyroidism in pregnancy, recommending a need for universal screening for all pregnant women in the early weeks of pregnancy. This study aims at validating the efficacy of the above-mentioned screening for a better pregnancy outcome.
Preliminary Phytochemical and Physiochemical Profile of Annona Squamosa Leaf
Authors: Kumar Vivek , Malik Jitender K
Published: October 2023

The macroscopical, microscopic, and early phytochemical studies on Annona squamosa Linn's leaf are the subject of the current communication. The herb Annona squamosa Linn has stimulant, antispasmodic, sudorific, anthelmintic, and insecticidal qualities, among other medicinal uses. All of the criteria were investigated in accordance with WHO and Pharmacopoeial standards. The quantitative evaluation of flavonoids included analysis that showed the leaf's potential.
Impact of Health on Labour Productivity: Evidence from Pakistan
Authors: Nisa Zaib-un
Published: October 2023

Health is an essential element that enables people to live their lives with great potential. A healthy life helps to live with confidence and self-esteem. At the macro level, the fundamental basis of economic development is health. At the micro level, health can effectively ensure productive and rewarding lives for people. Health affects economic growth in many ways, for example, poor health of workers causes a decrease in productivity, on the other hand, due to a healthy increase in nutrition productivity. The central objective of carrying out this study is to investigate the impact of human health on worker productivity. The health proxies used in this study are life expectancy. The indicator of education is enrollment at secondary level; Labor force and gross capital formation are also used as independent variables. The study used a panel of South Asian countries from 1991 to 2019, using the OLS panel, fixed effects model, random effects model, and generalized moments method (GMM). The results show that health and education have a significant and positive influence on productivity. This study recommends that the government of all South Asian countries take essential measures and establish policies related to improving health status and advancing the education system.
Analisis Penggunaan Bahasa Daerah dan Lemahnya Kemampuan Berbahasa Indonesia pada Siswa SD No. 249 Tunrung Ganrang
Authors: Rahmi Sri , Syukur Muhammad
Published: October 2023

Penelitian ini bertujuan untuk memahami hambatan dalam proses belajar mengajar siswa SDI No 249 Tunrung Ganrang dalam berbahasa Indonesia dan faktor penyebab bilingualisme pada siswa tersebut. Penelitian menggunakan pendekatan kualitatif dengan fokus pada komunikasi interpersonal dan lisan. Data dikumpulkan melalui wawancara dan observasi. Hasil penelitian menunjukkan bahwa siswa di SDI No 249 Tunrung Ganrang mengalami hambatan karena (a) keluarga menggunakan bahasa daerah dalam kehidupan sehari-hari, sehingga siswa tidak terbiasa dengan bahasa Indonesia dan kesulitan memahami materi yang diajarkan oleh guru, (b) siswa lebih sering menggunakan bahasa daerah dalam komunikasi sehari-hari karena tidak semua orang di desa menguasai bahasa Indonesia dengan baik, dan masyarakat desa merasa tidak nyaman menggunakan bahasa Indonesia formal. Sebagai hasilnya, masyarakat setempat lebih cenderung menggunakan bahasa Indonesia yang terkait dengan bahasa daerah mereka.
Analisa Peranan Tingkat Kemandirian Keuangan Daerah Kabupaten Manokwari
Authors: Tanudy Ayub , Parera Jemy Ricardo
Published: October 2023

Tujuan Penelitian ini adalah (1) Untuk mengetahui besarnya Rasio Kemandirian Keuangan Daerah di Kabupaten Manokwari, (2). Untuk mengetahui besarnya Rasio Ketergantungan Keuangan Daerah di Kabupaten Manokwari, (3) Untuk mengetahui besarnya Rasio Desentralisasi Fiskal Keuangan Daerah diKabupaten Manokwari.Rasio kemandirian daerah kabupaten manokwari selama lima tahun terakhir adalah masih sangat kurang tingkat kemandiriannya, dimana tahun 2017 tingkat kemandiriannya adalah 6.40 %,tahun 2018 adalah 9.86 % , tahun 2019 adalah 9.18 %, tahun 2020 adalah sebesar 7.61 %, tahun 2021 adalah sebesar 10.52 %, dengan demikian yang terendah adalah tahun 2017 sebesar 6.40 %, dan yang tertinggi adalah tahun 2021 sebesar 10.52 %. Rasio ketergantungan kabupaten manokwari selama lima tahun terakhir adalahmasih sangat tiggi tingkat ketergantungannya, dimana tahun 2017 tingkat kemandiriannya adalah 88.80 %,tahun 2018 adalah 76.59 % , tahun 2019 adalah 86.04 %, tahun 2020 adalah sebesar 83.57 %, tahun 2021 adalah sebesar 84.28 %, dengan demikian yang terendah adalah tahun 2018 sebesar 76.59 % , dan yang tertinggi adalah tahun 2017 sebesar 88.80 % Rasio kemandirian daerah kabupaten manokwari selama lima tahun terakhir adalah masih sangat kurang tingkat kemandiriannya, dimana tahun 2017 tingkat kemandiriannya adalah 5.56 %,tahun 2018 adalah 7.56 % , tahun 2019 adalah 7.90 %, tahun 2020 adalah sebesar 6.36 %, tahun 2021 adalah sebesar 8.87 %, dengan demikian yang terendah adalah tahun 2017 sebesar 5.56 % , dan yang tertinggi adalah tahun 2021 sebesar 8.87
Uji aktivitas antibakteri kombinasi ekstrak kulit dan biji Pepaya (Carica papaya L.) terhadap bakteri Staphylococcus aureus dan Escherichia coli
Authors: Ginting Indra , Rudang Singgar Ni , Andry Muhammad , Sari Mayang , Nasution Muhammad Amin
Published: October 2023

Pendahuluan; Penyakit infeksi yang banyak diderita masyarakat di antaranya infeksi Enterobacteria dari golongan E.coli dan infeksi kulit karena S.aureus. Salah satu tanaman yang berkhasiat sebagai antibaketri adalah pepaya seperti biji dan kulit nya. Tujuan; Penelitian dilakukan untuk mengetahui aktivitas ekstrak kombinasi kulit dan biji pepaya (Carica papaya L) terhadap S.aureus dan E.coli. Metode; Yang digunakan eksperimen. Ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 80%, 60%. 40% dan 20%. Uji Aktivitas antibakteri menggunakan metode difusi cakram dan uji skrining fitokimia pada ekstrak kulit pepaya (Carica papaya L). Hasil; Orientasi keempat etanol pada konsentrasi yang diambil (60:40) paling besar menghambat bakteri S.aureus dan E.coli adalah etanol 60% dengan diameter zona hambat 14,3 mm dan 14,0 mm.Hasil Uji skrining pada ekstrak kulit pepaya (Carica papaya L) terdapat positif pada alkaloid, saponin, flavonoid, tanin, dan Steroid. Hasil yang diperoleh pada etanol 60% menunjukkan bahwa ekstrak kombinasi kulit dan biji pepaya (Carica papaya L) pada S.aureus dengan konsentrasi (20:80) – (80:20) sebesar 11,9 mm - 15,6 mm. Pada E.coli dengan konsentrasi (20:80) – (80:20) sebesar 9,7 mm - 14,9 mm. Kesimpulan; Penelitian ekstrak kombinasi kulit dan biji pepaya (Carica papaya L) dari berbagai konsentrasi lebih besar menghambat bakteri S.aureus dibanding bakteri E.coli.
Ethical Practices in Information Service Provision at Makerere University Business school library, Uganda
Authors: - Olivia Nambobi , - Sarah Kaddu , - Bwengye Michael MMS , - Olive Tusiime
Published: October 2023

Ethical practice in information service provision involves choice of material, access, equality of treatment, copyright, intellectual freedom, protecting user’s rights, confidentiality, and, avoiding concealment of information, misinforming clients and divulging private information. The rationale of this study was to find out whether MUBS librarians are aware of these ethical practices and apply
Potato Starch Based Paper Coatings For Sustainable Packaging Applications
Authors: - Vivek Ramesh
Published: October 2023

As global environmental concerns continue to rise, there is an urgent need for sustainable alternatives in the packaging industry to reduce the environmental impact of traditional packaging materials. This research explores the potential of potato starch-based coatings as an eco-friendly alternative for paper-based packaging applications. The study investigates the feasibility of using locally sourced potato starch to create biodegradable and cost-effective coatings for paper packaging.
In this research, a simple and accessible method is employed to extract and process potato starch. The extracted starch is then used to develop paper coatings through a straightforward application process. The study examines the physical properties of these coatings, such as their tensile strength, oil resistance and water resistance. These properties are crucial for ensuring the durability and functionality of the packaging material.
Preliminary findings indicate that potato starch-based paper coatings exhibit promising adhesive properties and reasonable resistance to moisture, making them suitable for a variety of packaging applications. This research provides valuable insights into the potential of potato starch-based coatings as a sustainable alternative for paper packaging. The findings could have far-reaching implications for the packaging industry, offering a greener and more environmentally responsible solution to meet the growing demand for sustainable packaging materials.
A Study on the Socio Economic Impacts of Eco Tourism in Ladakh, India
Authors: - SUMEIR RAADHU
Published: October 2023

Ecotourism has risen as a solution to counter conventional tourism's adverse effects while encouraging local involvement. This study delves into the social and economic impacts of ecotourism in Ladakh, India, where growing tourism has presented both environmental issues and developmental prospects. Socially, ecotourism encourages cultural preservation but also raises concerns about tourists not respecting the culture. Economically, it creates jobs but struggles with income inequality. The study conducted a survey with 28 participants to understand the local sentiments about Ecotourism. This study comprehensively analysis ecotourism's social and economic effects in Ladakh, emphasising sustainable practices and community engagement to maximise benefits while minimising negative consequences in this unique Himalayan region.
Confluence of Artificial Intelligence (AI) in Education Sector
Authors: - DR. AAIMAN SIDDIQUI
Published: October 2023

The employment of artificial intelligence in the educational sector is discussed in this study. The 21st International Conference on Artificial Intelligence in Education, which was held in 2020, identified AIED as one of the most recent fields in educational technology to emerge. The use of AI and its potential effects on teaching and learning in higher education are still unclear to educators in terms of how to employ it for pedagogical purposes more generally. Here, the impact of AI on education as well as its benefits and drawbacks are discussed. Additionally, it describes how to develop an educational platform with AI capabilities. Finally, it discusses how AI has affected education.
Impact of COPD and Its Causes
Authors: - BEROJ STEENA , - NALINI JEYAVANTHA SANTHA
Published: October 2023

Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem that is increasing in prevalence. This progressive lung condition is characterized by irreversible air flow obstruction, mostly attributable to smoking, environmental and occupational exposures. It is a syndrome composed of chronic bronchitis, small air way disease and emphysema that vary in proportion between affected individuals.
On the Integration of the Higher Order Toda Lattice with a Self-Consistent Integral Type Source
Authors: Babajanov Bazar , Ruzmetov Murod
Published: October 2023

This work presents an algorithm that uses the inverse scattering method to find a solution for the higher-order Toda lattice with a self-consistent source. The higher-order Toda lattice with an integral-type source is also a significant theoretical model belonging to very integrable systems. The problem is solved by applying the direct and inverse scattering methods to the discrete Sturm-Liouville operator, and the time dependence of the scattering data for this operator is attained. The solution to the problem is set up using the inverse scattering transform (IST) approach.
Prostaglandin F2α synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F2α-dependent and F2α-independent mechanism
Authors: Wang Yi-Jun , Xie Xiao-Li , Liu Hong-Qun , Tian Hui , Jiang Xiao-Yu , Zhang Jiu-Na , Chen Sheng-Xiong , Liu Ting , Wang Shu-Ling , Zhou Xue , Jin Xiao-Xu , Liu Shi-Mao , Jiang Hui-Qing
Published: October 2023

Small extracellular vesicles (exosomes) are important components of the tumor microenvironment. They are small membrane-bound vesicles derived from almost all cell types and play an important role in intercellular communication. Exosomes transmit biological molecules obtained from parent cells, such as proteins, lipids, and nucleic acids, and are involved in cancer development. MicroRNAs (miRNAs), the most abundant contents in exosomes, are selectively packaged into exosomes to carry out their biological functions. Recent studies have revealed that exosome-delivered miRNAs play crucial roles in the tumorigenesis, progression, and drug resistance of hepatocellular carcinoma (HCC). In addition, exosomes have great industrial prospects in the diagnosis, treatment, and prognosis of patients with HCC. This review summarized the composition and function of exosomal miRNAs of different cell origins in HCC and highlighted the association between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC. Finally, we described the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC.
Development and validation of a nomogram for preoperative prediction of tumor deposits in colorectal cancer
Authors: Zheng Hui-Da , Hu Yun-Huang , Ye Kai , Xu Jian-Hua
Published: October 2023

Small extracellular vesicles (exosomes) are important components of the tumor microenvironment. They are small membrane-bound vesicles derived from almost all cell types and play an important role in intercellular communication. Exosomes transmit biological molecules obtained from parent cells, such as proteins, lipids, and nucleic acids, and are involved in cancer development. MicroRNAs (miRNAs), the most abundant contents in exosomes, are selectively packaged into exosomes to carry out their biological functions. Recent studies have revealed that exosome-delivered miRNAs play crucial roles in the tumorigenesis, progression, and drug resistance of hepatocellular carcinoma (HCC). In addition, exosomes have great industrial prospects in the diagnosis, treatment, and prognosis of patients with HCC. This review summarized the composition and function of exosomal miRNAs of different cell origins in HCC and highlighted the association between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC. Finally, we described the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC.
Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis
Authors: Chen Hong , Shen Yue , Wu Sheng-Di , Zhu Qin , Weng Cheng-Zhao , Zhang Jun , Wang Mei-Xia , Jiang Wei
Published: October 2023

Small extracellular vesicles (exosomes) are important components of the tumor microenvironment. They are small membrane-bound vesicles derived from almost all cell types and play an important role in intercellular communication. Exosomes transmit biological molecules obtained from parent cells, such as proteins, lipids, and nucleic acids, and are involved in cancer development. MicroRNAs (miRNAs), the most abundant contents in exosomes, are selectively packaged into exosomes to carry out their biological functions. Recent studies have revealed that exosome-delivered miRNAs play crucial roles in the tumorigenesis, progression, and drug resistance of hepatocellular carcinoma (HCC). In addition, exosomes have great industrial prospects in the diagnosis, treatment, and prognosis of patients with HCC. This review summarized the composition and function of exosomal miRNAs of different cell origins in HCC and highlighted the association between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC. Finally, we described the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC.
The Translation Methods Used in the Subtitles of Dialogues in Maleficent Movie
Authors: Nurhandini Andhita Hening , Wiyaka Wiyaka , B Th. Cicik Sophia
Published: October 2023

The objectives of this research are to find out the translation methods used in the dialogues, to find out the method that often appears in the subtitles of Maleficent movies, and to describe the quality level of English to Indonesian subtitles in Maleficent's translation. The theory used to analyze the translation method is the theory of Gottlieb (1992). This research is classified into qualitative descriptive research. The research data is from dialogue subtitles in the Maleficent film. The data source is obtained from the film Maleficent—data collection techniques with documentation. At the same time, data analysis is done by collecting, classifying, calculating, dominating, and drawing conclusions. The results of this research indicate that translators use six methods. These methods are paraphrasing (16,1%) and transfer (39,5%). Imitation (8,0%), condensation (8,0%), decimation (0,6%), and deletion (27,8%). From these results, it can be concluded that the translation method that translators dominantly use is the transfer method. Besides, subsequent research can provide knowledge that can be useful for readers and can be the next related research that will be reviewed. Further research is also needed to keep up with the development of translation studies.
Educaplay Una Plataforma Multimedia Para Crear Actividades Educativa Educaplay A Multimedia Platform To Create Educational Activities
Authors: Soledispa Baque Cesar Jorge , Delgado Palacios Angel Nahin , Lindao Macías Marlene Matilde
Published: October 2023

El contexto actual de la educación requiere de nuevos enfoques de enseñanza que permitan educar de forma interactiva al estudiante adaptandolas a las necesidades propias de cada entorno, promoviendo la participación activa, la motivación y la participación y el refuerzo de los contenidos curriculares de los estudiantes de primer Año de bachillerato mediante las estrategias didácticas mediadas por la plataforma web Educaplay, realizando un analisis de las falencias existentes en el proceso formativo de los módulo técnico de la especialidad de informática y asignatura del tronco común.  Para este escenario se usó la plataforma en línea que permite a los educadores crear diversos tipos de actividades interactivas gamificadas, como mapas interactivos, crucigramas, sopas de letras, y más. Estas actividades están diseñadas para involucrar a los estudiantes de manera activa, fomentando un aprendizaje activo y la gamificacion, alejandolos de los métodos de enseñanza tradicionales basados en la memorización y fomentando un aprendizaje más participativo.
The Development of Online Program During Pandemic in Menteng Seventh Day Adventist Church Jakarta
Authors: Kurniawan Raden Deddy , Hutagalung Stimson , Ferinia Rolyana , Sinaga Janes
Published: October 2023

The spiritual impact of pandemic Covid-19 is almost felt by every church in Jakarta. In addition to the closure of place of worship, the quality of service to reach each member who survived the pandemic needs to be maintained. Pastor as spiritual leaders in the congregation ought to be wise and creative in dealing with this phenomenon. This research is the result of development of online service that is being carried out by the author as a Pastor at Menteng Seventh-day Adventist Church in Jakarta in order to maintain the spiritual life of the congregation during the pandemic Covid-19. A quantitative approach by taking into the results of observations on the program that are currently being run is expected to help ministers in the congregation to develop consistency and quality of the program. With the advancement of technology in today’s era, the challenge of developing quality in online service to be a blessing for church members is possible. And the results of this development program are not only helping a Pastor to be able to create spiritual programs for the congregation, but more broadly the church can grow spiritually
Peran Gembala Dalam Meningkatkan Pertumbuhan Gereja
Authors: Sinambela Juita Lusiana , Sinaga Janes , Woran Ramlen
Published: October 2023

Tujuan penelitian ini adalah agar setiap gembala dan anggota jemaat memahami dan memiliki keinginan gerejanya bertumbuh, karena demikianlah yang dikehendaki Tuhan. Tidak dapat dipungkiri kemajuan gereja terkadang mengalami maju-mundur. Dalam hal ini banyak hal yang mempengaruhi, mulai dari kurangnya keterlibatan anggota dalam pelayanan, penginjilan hingga pemuridan. Namun demikian perlu dipahami akan semua hal ini gembala jemaat mempunyai peran penting dalam menggerakkan semua hal tersebut. Penelitian ini menggunakan metode kualitatif deskriptif kajian literatur dengan menggali mengapa penting terjadinya pertumbuhan dalam gereja sehingga menjadi motivasi bagi setiap gembala dan anggota jemaat memajukan setiap gereja, yang semuanya hanya untuk memajukan pekerjaan Tuhan di muka bumi.