bluuebunny/crossref_metadata_2025 huggingface dataset:
Synovial microflora of large joints in patients of a multidisciplinary hospital
Authors: Schendrigin Ivan  N. , Podsvirova Irina  A.
Published: May 2022

Relevance. There is no doubt that microorganisms participate in occurrence and development of septic process in joints. However, the issue of etiological significance of each agent remains controversial, because, in spite of the general trends, indicating the participation of numerous microorganisms in the development of articular pathology, each result of microbiological analysis concerns only a specific case in the territorial and clinical aspects. The aim of the study - microbiological research of synovial fluid obtained from knee joint during synovitis after its aspiration in patients of various departments of the Stavropol Regional Clinical Hospital. Materials and Methods . There were studied 198 samples of synovial fluid. Primary inoculation of puncture was performed with subsequent isolation, identification of the cultures by mass spectrometry and assessment of their antibiotic sensitivity by discodiffusion method. Results and Discussion . 11 cultures of bacterial pathogens were isolated. Gram-positive cocci - 82 %, of which 77.8 % - microorganisms of Staphylococcus genus (44.4 % S.aureus , 33.4 % S.epidermidis ), 22.2 % - other gram-positive cocci: one strain of each, Enterococcus faecium and Streptococcus mitis . Gram-negative pathogens are represented by K.neumoniae and P.aeruginosa with a total content of 18 %. Highly virulent microorganisms S.aureus , K.neumoniae and P.aeruginosa are isolated from the synovial fluid of patients of the surgical departments (orthopedotraumatological No. 1, No. 2) and the rheumatological department. Microorganisms with low virulence E.faecium , S.mitis and S.epidermidis are isolated from synovial fluid of patients of various departments. No obvious resistance of isolated pathogens to antimicrobial drugs has been registered. Conclusion . The presence and species affiliation of the microorganisms identified in synovial fluid allows predicting their etiological significance in development of septic process in joints. Their role as causative agents of nosocomial infections typical for a medical institution is not excluded. The presence of articular pathology in each of the examined departments dictates the need for a clear understanding of the importance of timely and high-quality joint aspiration followed by microbiological examination in almost all patients with damage of large joints, including patients without clinical signs of septic arthritis. Such an approach that makes it possible to identify a greater number of causative agents of septic arthritis and quickly evaluate the dynamics of their antimicrobial resistance should become an obligatory part of a comprehensive research and treatment of a patient with arthritis in multi-fi eld hospitals.
Glenoid cavity morphometric study in human scapula
Authors: Sinsinwar Pankaj , Chawla Maheshwar , Mishra Abhibhusan , Sharma Devesh Kumar
Published: May 2022

Relevance. Scapula is one of the bones that takes part in the formation of shoulder joint and has variable morphology. It is weak joint because glenoid cavity is variable in vertical diameter and transverse diameter. Hence glenoid cavity is shallow and gives rise to frequent dislocation of shoulder joint. Aim of the present study was to know various dimensions of glenoid cavity like vertical diameter and horizontal diameter and their variations in percentages. Materials and Methods. Fifty unknown dry human scapulae from the department of anatomy (Mahatma Gandhi Medical College, Sitapura, Jaipur, Rajasthan, India) constituted the materials for the present study. Each scapula was studied for glenoid cavity. The vertical diameter and horizontal diameters were studied from each above scapula. Twenty five scapulae were from right side and twenty five were from left side. The different shapes of glenoid cavity were observed. The shapes were pear shaped, inverted comma shaped and oval shaped. Results and Discussion. In the present study pear shaped glenoid cavity was found in 56 %, Inverted comma shape was found in 26 % and oval shape was observed in 18 %. The most common shape was pear shape (56 %) and least common shape was oval shape (18 %). The mean glenoid height was 35.52 mm. The maximum glenoid height was 41.22 mm and minimum glenoid height was 30.19 mm. The mean glenoid width was 20.77 mm. The maximum glenoid width was 24.31 mm and minimum glenoid width was 17.93 mm. Conclusion. Study showed that glenoid cavity has varied morphology. This varied morphology will be of great useful in various clinical and surgical procedures like hip replacement and in posterior glenoid osteotomy.
Prophets and people of the Semitic religion in English translated Quran: Corpus and CDA over western power dominance
Authors: Farah Rafika Rabba , Sumarsono Puji , . Sukarma
Published: May 2022

The Quran is the oldest scripture revealed by Allah to the Prophet Muhammad (peace be upon Him), and its originality has been preserved to this day, as evidenced by the language it employs—Arabic. It has become a popular reference for Muslims and non-Muslims alike, especially since the 9/11 tragedy. Not surprisingly, its native text, Arabic, is now widely available in translated versions, with English-translated Quran being the most frequent. The current study intends to investigate the meta-religious text concerning Prophets and the people mentioned in the Quran. The primary data of this study were obtained from the English-translated Quran by Talal Itani and analyzed with qualitative analysis software, NVivo 12 Plus, using the text search and query feature. Following that, discourse analysis was used to examine the text, social cognition, and sociocultural context. The results indicate that Moses ranked first in the Prophets category with 135 references, while the other prophets had a varied distribution: Abraham had 72, Jesus had 25, and Muhammad had 12 references. People of Israel were the most frequently discovered words with 42 mentions, followed by Jew, Christian, and Muslim. This research reveals surprising discursive evidence showing Muhammad and Muslims were the lowest of all categories. This means that the Quran is a revelation that is aimed not only for Muslims but also for all humanities, particularly the other Semitic religions: Christianity and Judaism.
Integrating 21st-century skills in English material development: What do college students really need?
Authors: Menggo Sebastianus , Ndiung Sabina , Midun Hendrikus
Published: May 2022

The 21st-century education emphasizes a number of indicators that teachers, students, parents, and other education stakeholders should completely understand. English teachers should be encouraged to be able to integrate the intended 21st-century competency indicators into instructional materials that are preceded by a needs analysis stage. Needs analysis is crucial in designing English materials as it serves as a valuable tool for practitioners to create English materials aligned with students' target and learning needs. As a consequence, needs analysis is seen as a necessary component of the teaching practice. The purposes of this study are to examine and reveal the numerous types of students' target needs and learning needs for English material development. This study examined two English lecturers and 206 students enrolled in the primary education department. The data collection instrument was a questionnaire and the data were analyzed using a software program, namely an excel chart data series. Findings indicated that the students' target needs included necessities, lacks, and wants, whereas learning needs included input, procedure, setting, learner's role, and lecturer's role in the teaching-learning process. Students' target and learning needs emphasized the importance of developing English materials that boosted 21st-century education skills. English materials should be adjusted to meet the needs of students' future careers, with a particular emphasis on the eleven sub-skills of 21st-century education.
Unpacking the opportunities and challenges in learning speaking online during Covid-19 outbreak: A case-study of Indonesian EFL college students
Authors: Syafrayani Putri Rizki , Ginting Pirman , Hasnah Yenni , Saragih Mandra
Published: May 2022

The challenges brought by Covid-19 have threatened not only the economy and health fields but also the educational sectors. In light of education, this issue has led to the swift migration of the learning process from conventional mode to online learning which has resulted in another bottleneck. The current study explores the perception of EFL Indonesian college students about the challenges and benefits of learning speaking through the online system during the Covid-19 outbreak. Forty-five college students participated in this study and were inquired through a semi-structured questionnaire in the weeks following the final term examinations for the academic year 2020-2021. The data was probed by using grounded theory proposed by Creswell. The findings exposed that effectiveness, online benefits, and improvement opportunities were the benefits obtained by students from the online learning. Meanwhile, distraction and information overload, a technical error in online learning technology and internet connectivity matters as well as limited interaction and inadequate support were hindrances that often hampered the students.  Consequently, this scholarly paper also provides advice on the essence of the readiness of adequate facilities and the collaboration from stakeholders; government, teachers, students, and parents to successfully implement online learning.
Investigating translation strategies in Indonesian best seller novel
Authors: Fata Ika Apriani , Jannah Miftahul , Daud Bukhari , Muktabar Fadhilah , Wahyuni Sri
Published: May 2022

Translation strategies have been the subject of extensive investigation. Most people believe that translators use specific strategies and that basic translation strategies are sometimes insufficient. As a result, numerous scholars have investigated and analyzed various translation techniques from various perspectives. This study determined the translation strategies in the novel of Negeri 5 Menara and its English Version, The Land of Five Towers using Baker's (2011) framework. This study was conducted using a descriptive qualitative technique to determine the translation strategies in Negeri 5 Menara and its English version, The Land of Five Towers. There were 130 data points in all. According to the findings, 11% about the use of the more general word, 14 % in the use of the more neutral or expensive word, 8% of cultural substitution, 5% of loan words, 4% of omission, paraphrase with related terms accounted for 57% of all translation tactics, while paraphrasing with unrelated words accounted for 2%, and there was no data on illustration. There were 21 uncategorized data points for every given strategy. It was predicted that in the future, a translator, who is also a pre-service teacher, should widen his or her translation methodologies in order to combat non-equivalence translation.
Tamimah dalam Perspektif Hadis
Authors: Zulihafnani Zulihafnani , Salwati Salwati
Published: May 2022

Tamimah is a rope that is worn by Arabs around the neck of children with the assumption that it can protect them from other diseases or eye diseases. Islam came and forbade all things related to shamanism in the form of amulets or spells and anything related to them is an evil that must be fought, except those that come from the Qur'an or spells that are ma'tsur. Based on this problem, the author wants to examine how the quality of the hadiths, both those that allow and forbid and how to resolve them. Based on the results of the research, the authors found that the hadiths that seemed contradictory regarding the permissibility of using amulets could be compromised in order to avoid conflict and could be practiced together, considering that these hadiths met the criteria for the validity of the hadith. Thus, these traditions are maqbul hadiths with the status of valid traditions. So even though there are more hadiths that prohibit tamimah, all forms of amulets, whether from the Qur'an or not, are permissible under certain circumstances. The hadith about amulets is prohibited because some friends think that amulets are shirked because they deny belief in Allah swt. In fact, every form of the disease has a cure and the disease is cured with the permission of Allah swt. Tamimah adalah tali yang dikalungkan orang arab di leher anak-anak dengan anggapan bahwa hal tersebut dapat menjaga mereka dari penyakit ain atau mata. Islam datang dan melarang segala hal yang berkaitan dengan perdukunan baik berupa jimat maupun mantra dan apapun yang berkaitan dengannya adalah kemungkaran yang harus diperangi, kecuali yang berasal dari al-Qur’an atau mantra yang ma’tsur. Berdasarkan permasalahan ini, penulis ingin mengakaji bagaimana kualitas hadis-hadis  baik yang membolehkan maupun yang melarang dan bagaimana penyelesaiannya. Berdasarkan hasil penelitian penulis menemukan hadis-hadis yang tampak saling bertentangan terkait kebolehan penggunaan jimat dapat dikompromikan agar terhindar dari pertentangan dan dapat diamalkan secara bersama-sama, mengingat hadis-hadis tersebut memenuhi kreteria kesahihan hadis. Dengan demikian hadis-hadis tersebut merupakan hadis maqbul dengan berstatus hadis sahih. Jadi walaupun lebih banyak hadis yang melarang tamimah, namun segala bentuk jimat baik dari al-Qur`an ataupun bukan, itu dibolehkan dalam keadaan tententu. Dilarangnya hadis tentang jimat itu karena beberapa sahabat beranggapan bahwasanya jimat itu syirik karena menafikan kepercayaan kepada Allah swt. Padahal sesungguhnya segala bentuk penyakit ada obatnya dan penyakit tersebut sembuh dengan izin Allah swt.
La participación popular en la política a través de las Sociedades Democráticas
Authors: Restrepo Víctor
Published: May 2022

A mediados del siglo XIX una sed de participación ampliada y reformas estructurales atraviesa los países occidentales. El liberalismo y el republicanismo surgen como dos conceptos que permiten articular los objetivos de los que quieren un profundo cambio en sus naciones. Colombia no se verá ajena a este momento de la era de las revoluciones. Al contrario, a mediados del siglo se llevará a cabo la revolución liberal. Para esto, se conformarán, como en Francia, Sociedades Democráticas; organizaciones en las que diversos grupos sociales discutirán sobre el significado de la nación, la representatividad política, la república, la representación y, en últimas, su participación política. En estos grupos el artesanado tendrá un rol protagónico. La reconfiguración de la cultura política estará marcada por alianzas endebles y pugnas, en las que cada sector intentará imprimir sus propias prácticas y significados a los conceptos del dialogo y de la construcción del cambio. Ello implica que en cada región la composición y, por lo tanto, la evolución de las Sociedades Democráticas será diferente. En Cali, estas organizaciones políticas conformadas por diversos grupos y razas con trayectorias, posiciones e intereses diversos, se articularon de maneras específicas según el contexto, marcando la evolución de estas organizaciones.
mentalidad pre-moderna: un acercamiento al proceso de desarrollo cognitivo de la especie humana
Authors: Rojas Luisa Fernanda
Published: May 2022

Con frecuencia se da por sentado que en todas las formas de vida social, construidas por el ser humano, este ha contado con las mismas posibilidades respecto a la forma como puede organizar la información que extrae de la interacción con el mundo exterior ya dado. Se argumenta que, dado que la creación y el uso de símbolos es un fenómeno registrado desde las primeras sociedades humanas, las posibilidades cognitivas de organización mental son también las mismas. No obstante, son las formas de pensamiento las que limitan la construcción del orden social, y es necesario comprender el desarrollo de esas formas para comprender las condiciones bajo las cuales se han construido las sociedades históricas y la nuestra propia. El siguiente artículo es un primer acercamiento a comprender el cambio de mentalidad que supuso la entrada de la Edad Moderna para la especie humana.
Autorrepresentação indígena como política de identidades em luta
Authors: Kaseker Monica , Nakamura Gallassi Adriana , Ribeiro Lucas Fernando
Published: May 2022

Desde a chegada portuguesa ao Brasil, em 1500, os povos originários foram representados pelo viés eurocêntrico. Foi assim nas cartas dos primeiros exploradores enviadas à Coroa, nos sermões de catequização, nas pinturas feitas durante expedições que documentaram o território e, mais tarde, em livros, materiais didáticos, audiovisuais e jornalísticos. O giro decolonial começa no final do Século XX, quando indígenas brasileiros passam a registrar e publicar imagens e narrativas próprias. Por meio de pesquisa teórica e revisão bibliográfica, na perspectiva dos Estudos Culturais e Decoloniais, constata-se que a comunicação consiste no elemento central das políticas de identidade indígena e a autorrepresentação demarca a  ruptura com a imagem do índio genérico, estereotipado e parado no tempo, o que consideramos uma política de identidades em luta.
Simultaneous infection of CIED and newly implanted leadless cardiac pacemaker
Authors: Wu Mengwei , Su Hao
Published: May 2022

CIED infection is a serious complication and remains the commonest
indication for TLE.The patient exist two problems: bilateral venous
access infection and pacing dependence. LP provide safe and effective
pacing options for patients with device-related infections.
It's time for a fivesome.
Authors: Trumello Cinzia , Giambuzzi Ilaria
Published: May 2022

t’s time for a fivesome. Commentary to: “The predictive value of five
glomerular filtration rate formulas for long-term mortality in patients
undergoing coronary artery bypass grafting” Coronary artery disease is
an extremely common condition and coronary artery bypass-grafting is
still one of the most important therapeutic strategy to treat it.
Chronic kidney disease is often affecting patients with CAD.
Nevertheless, the literature is still debating what formula estimate the
best the glomerular filtration rate in patients undergoing CABG. Indeed,
the formulas used in clinical practice have some differences some are
more accurate in patients with diabetes, while there are some bias given
by age and body mass index. In cardiac surgery, the choice of the most
fitting formula to evaluate GFR has important clinical implication and,
up to now, three formulas have been compared at most. Eilon Ram et al.
present a retrospective study which compares the 5 most used formulas
(CG, MDRD, CKD-EPI, Mayo, and IB) to derive GFR to evaluate the one with
the best accuracy in predicting long-term mortality. In order to do so,
they divided 3744 patients in three groups according to the estimated
GFR by means of all 5 formulas: significant CKD according to all
formulas, non-significant CKD according to all formulas and discordant
results (meaning that at least one formula gave normal GFR and at least
one formula gave abnormal GFR). Patients with the highest mortality were
the ones with significant CKD according to all formulas.
Patient perspective: coping with preoperative anxiety in patients scheduled for coronary artery by-pass surgery. A mixed-methods study.
Authors: Zemła Adam , Jarmoszewicz Krzysztof , Hajduk Adam , Nowicka-Sauer Katarzyna
Published: May 2022

Background Despite substantial literature that addresses
preoperative anxiety, identifying effective anxiety-management
interventions is still recommended. Identifying factors related to
preoperative anxiety is essential for intervention planning.
Aim To explore patient-reported factors contributing to
decreased anxiety among patients scheduled for coronary artery by-pass
grafting (CABG). Methods This mixed-methods observational study
involved 75 patients aged 40-83 (70.7% men; mean age 65.4±9.41).
Qualitative analysis involved 25 randomly selected patients (focus
group) and asked to specify factors they believed were helpful in
reducing their anxiety. Visual Analogue Scale (VAS-Anxiety) was used at
the moment of diagnosis and decision making (Time1, retrospectively),
and on the day preceding CABG (Time2). Focus group responses were
explored with the use of Interpretative Phenomenological Analysis (IPA).
The Pearson’s chi -squared and the Mann-Whitney-U tests were
calculated to explore differences between the study groups. Significance
level α≤0.05 was used in all analyses. Results VAS-Anxiety
scores reduced from 5 points at Time1 to 3 points at Time 2
(p<0.01). Fifty patients (66.7%) reported decreased anxiety
between Time1 and Time2, 21 (28%) reported a stable level and 4 (5.3%)
reported an increase. Employment status was the only significant factor
differentiating “relief’ and “no relief” groups among
socio-demographic and clinical variables. IPA yielded five main themes:
conversations with health care providers, perceived inevitability of
surgery, family support, other patients’ experience, and religion/faith.
Conclusions Individual patient-centered interview in
conjunction with emotional support are vital for managing preoperative
anxiety. Providing contact with family members and paying attention to
spiritual needs are also important.
Practical Actions to Operationalize the One Health Approach in the Asian Development Bank
Authors: Habib Najibullah , Parry Jane , Elfving Rikard , Dunn Bruce
Published: May 2022

This working paper explains the concept of One Health and how it aligns with ADB’s Strategy 2030 and operational priorities for development efforts in Asia and the Pacific. The One Health approach has the potential to transform the work of international development organizations including ADB. This working paper elaborates on how One Health can be instrumental in ADB’s efforts to support recovery from the coronavirus disease (COVID-19) pandemic in the Asia and Pacific region, along with other development issues including antimicrobial resistance, food security, ecological security, biodiversity, human health, and climate change.
Real time prediction method of energy consumption of geothermal system in public buildings based on wavelet neural network
Authors: Li Yongguang , Guo Shaocui
Published: May 2022

Real time prediction of energy consumption is the basis of energy
conservation and emission reduction. Aiming at the problems of large
prediction error and poor effect, a real-time prediction method of energy
consumption of geothermal system of public buildings based on wavelet neural
network is proposed. Firstly, the energy consumption of geothermal system
in public buildings is analyzed, the wavelet neural network is designed, the
neural network is optimized and solved by genetic algorithm, and the
necessity of constructing the real-time prediction model of energy
consumption based on wavelet neural network is established. Then it
introduces the basic principle of model establishment, wavelet analysis, and
shows the role of wavelet analysis in prediction model. Finally, based on
the distribution structure of public buildings, this paper analyzes the
energy consumption system of geothermal system, constructs the energy
consumption prediction method, analyzes the over?all temperature regulation
energy consumption prediction principle of building geothermal system, and
realizes the real-time prediction of energy consumption of geothermal system
of public buildings. The experimental results show that the energy
consumption real-time prediction results of the designed method are
basically similar to the actual prediction values, and the prediction
efficiency is high, which can effectively reduce the energy consumption of
the geothermal system of public buildings.
Report Users' Perceived Sentiments of Key Audit Matters and Firm Performance: Evidence from a Deep Learning-Based Natural Language Processing Approach
Authors: Liu Wu-Po , Yen Meng-Feng , Wu Tai-Ying
Published: May 2022

We investigate the associations between the sentiment report users perceive in key audit matters (KAMs) and current and future firm performance. We also investigate the validity of the bidirectional encoder representations from transformers (BERT) model for automatically extracting KAM sentiment in Taiwanese listed firms' audit reports. Positive associations between KAM sentiment and current and next-year firm performances, measured by Tobin's Q, ROA, and ROE, are discovered based on a two-year sample of 1,606 firm–year observations, including manually labeled sentiment data in 2017 and BERT-extracted sentiment data in 2018. However, the evidence of the positive association between KAM sentiment and current firm market performance (Tobin's Q) is weaker in 2017 than in 2018 statistically. Our results suggest that KAM sentiment reflects future firm performance and support the application of the BERT deep learning approach for textual mining. This study has implications for regulators, practitioners, and academics.

JEL Classifications: D83; L25; M42.
Do Managers Learn from Analysts about Investing? Evidence from Internal Capital Allocation
Authors: Guo Re-Jin , Zhong Rong
Published: May 2022

Analysts are recognized for their expertise in predicting industry growth, yet little is known about whether CEOs learn from analysts’ insights to guide investment decisions. Focusing on conglomerates where CEOs are underinformed about segment growth opportunities, we find that CEOs learn industry insights from analysts to adjust internal capital allocation. The extent of learning increases when analysts have closer proximity to CEOs or expertise in segments where CEOs face larger internal knowledge gaps. CEOs likely learn from analysts through private communications, as the insights learned are not yet publicly available, difficult to replace with other sources, and persistently impactful for firms. CEOs also exploit conference calls as another way to learn from analysts. As a result, learning analysts’ insights enhances firm value. We employ brokerage mergers/closures as a quasi-experiment to address endogeneity concerns. Overall, our study provides novel evidence on a learning channel through which analysts add value to firms.

JEL Classifications: D80; D83; G10; G31.
Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization
Authors: Wrublewsky Selina , Speer Thimoteus , Nalbach Lisa , Boewe Anne S. , Pack Mandy , Alansary Dalia , Roma Leticia P. , Hoffmann Markus D.A. , Schmitt Beate M. , Weinzierl Andrea , Menger Michael D. , Laschke Matthias W. , Ampofo Emmanuel
Published: May 2022

Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3) inflammasome is expressed in pancreatic islets and that its loss protects against hypoxia-induced cell death. Therefore, we hypothesized that the inhibition of NLRP3 in islets improves the survival and endocrine function of the grafts. The transplantation of Nlrp3−/− islets or wild-type (WT) islets exposed to the NLRP3 inhibitor CY-09 into mouse dorsal skinfold chambers resulted in an improved revascularization compared with controls. An increased insulin release after NLRP3 inhibition caused the enhanced angiogenic response. Moreover, the inhibition of NLRP3 in hypoxic β-cells triggered insulin gene expression by inducing the shuttling of MafA and pancreatic and duodenal homeobox-1 into the nucleus. This was mediated by a reduced interaction of NLRP3 with the thioredoxin-interacting protein (TXNIP). Transplantation of Nlrp3−/− islets or WT islets exposed to CY-09 under the kidney capsule of diabetic mice markedly improved the restoration of normoglycemia. These findings indicate that the inhibition of NLRP3 in isolated islets represents a promising therapeutic strategy to improve engraftment and function of the islets.
Diabetic Neuropathy in Hands: An Endemic Complication Waiting to Unfold?
Authors: Sierra-Silvestre Eva , Andrade Ricardo J. , Schroeter Andrea C. , Bisset Leanne , Coppieters Michel W.
Published: May 2022

In this cross-sectional study we aimed to quantify the somatosensory dysfunction in the hand in people with diabetes with distal symmetrical polyneuropathy (DSPN) in hands and explore early signs of nerve dysfunction in people with diabetes without DSPN in hands. The clinical diagnosis of DSPN was confirmed with electrodiagnosis and corneal confocal microscopy. Thermal and mechanical nerve function in the hand was assessed with quantitative sensory tests. Measurements were compared between healthy participants (n = 31), individuals with diabetes without DSPN (n = 35), individuals with DSPN in feet but not hands (DSPNFEET ONLY) (n = 31), and individuals with DSPN in hands and feet (DSPNHANDS & FEET) (n = 28) with one-way between-group ANOVA. The somatosensory profile of the hand in people with DSPNHANDS & FEET showed widespread loss of thermal and mechanical detection. This profile in hands is comparable with the profile in the feet of people with DSPN in feet. Remarkably, individuals with DSPNFEET ONLY already showed a similar profile of widespread loss of nerve function in their hands. People with diabetes without DSPN in feet already had some nerve dysfunction in their hands. These findings suggest that nerve function assessment in hands should become more routine in people with diabetes.
Association of HLA-DQ Heterodimer Residues −18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial–Type 1
Authors: Zhao Lue Ping , Skyler Jay , Papadopoulos George K. , Pugliese Alberto , Najera James Antonio , Bondinas George P. , Moustakas Antonis K. , Wang Ruihan , Pyo Chul-Woo , Nelson Wyatt C. , Geraghty Daniel E. , Lernmark Åke
Published: May 2022

OBJECTIVE

The purpose was to test the hypothesis that the HLA-DQαβ heterodimer structure is related to the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS

Next-generation targeted sequencing was used to genotype HLA-DQA1-B1 class II genes in 670 subjects in the Diabetes Prevention Trial–Type 1 (DPT-1). Coding sequences were translated into DQ α- and β-chain amino acid residues and used in hierarchically organized haplotype (HOH) association analysis to identify motifs associated with diabetes onset.

RESULTS

The opposite diabetes risks were confirmed for HLA DQA1*03:01-B1*03:02 (hazard ratio [HR] 1.36; P = 2.01 ∗ 10−3) and DQA1*03:03-B1*03:01 (HR 0.62; P = 0.037). The HOH analysis uncovered residue −18β in the signal peptide and β57 in the β-chain to form six motifs. DQ*VA was associated with faster (HR 1.49; P = 6.36 ∗ 10−4) and DQ*AD with slower (HR 0.64; P = 0.020) progression to diabetes onset. VA/VA, representing DQA1*03:01-B1*03:02 (DQ8/8), had a greater HR of 1.98 (P = 2.80 ∗ 10−3). The DQ*VA motif was associated with both islet cell antibodies (P = 0.023) and insulin autoantibodies (IAAs) (P = 3.34 ∗ 10−3), while the DQ*AD motif was associated with a decreased IAA frequency (P = 0.015). Subjects with DQ*VA and DQ*AD experienced, respectively, increasing and decreasing trends of HbA1c levels throughout the follow-up.

CONCLUSIONS

HLA-DQ structural motifs appear to modulate progression from islet autoimmunity to diabetes among at-risk relatives with islet autoantibodies. Residue −18β within the signal peptide may be related to levels of protein synthesis and β57 to stability of the peptide-DQab trimolecular complex.
Effect of Deintensifying Diabetes Medications on Negative Events in Older Veteran Nursing Home Residents
Authors: Niznik Joshua D. , Zhao Xinhua , Slieanu Florentina , Mor Maria K. , Aspinall Sherrie L. , Gellad Walid F. , Ersek Mary , Hickson Ryan P. , Springer Sydney P. , Schleiden Loren J. , Hanlon Joseph T. , Thorpe Joshua M. , Thorpe Carolyn T.
Published: May 2022

OBJECTIVE

Guidelines advocate against tight glycemic control in older nursing home (NH) residents with advanced dementia (AD) or limited life expectancy (LLE). We evaluated the effect of deintensifying diabetes medications with regard to all-cause emergency department (ED) visits, hospitalizations, and death in NH residents with LLE/AD and tight glycemic control.

RESEARCH DESIGN AND METHODS

We conducted a national retrospective cohort study of 2,082 newly admitted nonhospice veteran NH residents with LLE/AD potentially overtreated for diabetes (HbA1c ≤7.5% and one or more diabetes medications) in fiscal years 2009–2015. Diabetes treatment deintensification (dose decrease or discontinuation of a noninsulin agent or stopping insulin sustained ≥7 days) was identified within 30 days after HbA1c measurement. To adjust for confounding, we used entropy weights to balance covariates between NH residents who deintensified versus continued medications. We used the Aalen-Johansen estimator to calculate the 60-day cumulative incidence and risk ratios (RRs) for ED or hospital visits and deaths.

RESULTS

Diabetes medications were deintensified for 27% of residents. In the subsequent 60 days, 28.5% of all residents were transferred to the ED or acute hospital setting for any cause and 3.9% died. After entropy weighting, deintensifying was not associated with 60-day all-cause ED visits or hospitalizations (RR 0.99 [95% CI 0.84, 1.18]) or 60-day mortality (1.52 [0.89, 2.81]).

CONCLUSIONS

Among NH residents with LLE/AD who may be inappropriately overtreated with tight glycemic control, deintensification of diabetes medications was not associated with increased risk of 60-day all-cause ED visits, hospitalization, or death.
Causal graph between serum lipids and glycemic traits: a Mendelian randomization study
Authors: Zhu Ziwei , Wang Kai , Hao Xingjie , Chen Liangkai , Liu Zhonghua , Wang Chaolong
Published: May 2022

  

We systematically investigated the bidirectional causality between high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), triglycerides (TG), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (sample size n = 1,320,016 for lipids, 151,013 for FI, and 344,182 for HbA1c). We applied multivariable Mendelian randomization (MR) to account for the correlation between different traits, and constructed a causal graph with 13 significant causal effects after adjusting for multiple testing (P < 0.05/20). Remarkably, we found the effects of lipids on glycemic traits were through FI from TG (β = 0.06 [95% CI: 0.03, 0.08] in unit of 1-SD for each trait) and HDL-C (β = -0.02 [-0.03, -0.01]). On the other hand, FI had strong a negative effect on HDL-C (β = -0.15 [-0.21, -0.09]) and positive effects on TG (β = 0.22 [0.14, 0.31]) and HbA1c (β = 0.15 [0.12, 0.19]), while HbA1c could raise LDL-C (β = 0.06 [0.03, 0.08]) and TG (β = 0.08 [0.06, 0.10]). These estimates derived from the inverse-variance weighting method were robust when using different MR methods. Our results suggested that elevated FI was a strong causal factor of high TG and low HDL-C, which in turn would further increase FI. Therefore, early control of insulin resistance is critical to reduce the risk of type 2 diabetes, dyslipidemia, and cardiovascular complications. 
STABILITAS LERENG DAN BENDUNG PADA EMBUNG DS. NGAWU, KEC. PLAYEN, KAB. GUNUNG KIDUL, DIY
Authors: Gunawan Sumiyati , Sulistyowati Yenny Endang , Timur Haniti Mangku
Published: May 2022

Desa Ngawu, Kab. Gunung Kidul salah satu daerah yang saat kemarau selalu mengalami kekeringan. Karena memiliki jenis tanah lempung lunak, yang membuat bergesernya buis beton ke tengah embung saat pelaksanaan embung kecil terdahulu. Minimnya dana dalam proses pengerjaan embung kecil tersebut,  menjadi penyebab perencanaan talud yang tidak maksimal. Upaya yang dilakukan dalam memenuhi kebutuhan air di Desa Ngawu adalah membuat embung memanjang. yang aman dari bahaya guling, geser, piping dan daya dukung tanah. Dilakukan pengujian sondir, boring dan pengukuran pemetaan untuk data pengukuran lokasi dan parameter tanah untuk menganalisis stabilitasnya .  Perencanaan talud menggunakan bronjong (kawat yang dianyam dengan lubang segi enam, diisi batu pecah yang berada di lokasi dengan berat volume ± 20 kN/m3). Langkah pertama,  mencari garis longsor kritis dengan menggunakan metode Fellinius. Langkah kedua, desain dimensi bronjong dan analisis stabilitas. Data hidrologi berupa hasil dimensi bendung, diambil  dari hasil TGA Usfi Ula Kalwa yang berjudul “Perencaaan Embung Memanjang Ds. Ngawu, Kec. Playen, Kab. Gunung Kidul, Yogyakarta”. Dari hasil analisis, maka diambil garis longsor dengan SF=2.54 , dasar bonjong pada 3,00m dari muka tanah. Stabilitas bronjong (SF) terhadap bahaya bahaya guling, geser,dan daya dukung tanah adalah sebagai berikut 14.134 ; 2.99 ; dan 8.5. Stabilitas bendung (SF), terhadap bahaya guling, geser, piping dan daya dukung tanah adalah sebagai berikut 5.053 ; 2.0 ; 6 ; dan 3.9 , Sehingga dapat disimpulkan tidak diperlukan perencanaan angker untuk menambah kekuatan stabilitas.
EVALUASI PERATURAN PEMBEBANAN GANDAR KERETA API DI PULAU JAWA TERHADAP KONDISI AKTUAL
Authors: Muspitasari Tri , Sulistyowati Indah , Kumara Widi
Published: May 2022

Abstract: The railway structure includes a variety of constructions intended to supportrailroad and railway operations, one of which is a bridge. Locomotives are self-rail vehiclesthat function as rod or train carriages. Locomotives in Indonesia, especially in Java Island,have varying axle loads and axle distances, thus causing an inward force change that works onthe railway structure. The live load working on the structure of the railway bridge is a loadderived from a railway circuit whose size is determined based on the loading scheme of the1921 Load Plan (RM 1921). With RM 1921 which has been established as a rule of Bridgethrough which a series of railways passing then at a certain point on the bridge girder lengthenswill cause an inner force such as the force of moment and latitude that changes in magnitudedepending on the location of the train circuit. However, the actual condition of axle load andaxle distance is not in accordance with RM 1921. To know the magnitude of force in(maximum moment) then required an analysis calculation that is using line of influence. Fromthe calculation result between actual locomotive and RM 1921, it can be concluded that theactual maximum force of the locomotive is 30.38% less than RM 1921, therefore RM 1921 isstill sufficient to be used in the current condition Abstrak: Struktur jalan rel meliputi bermacam-macam konstruksi yang dimaksudkan untukmendukung jalan rel dan pengoperasian kereta api salah satunya adalah jembatan. Lokomotifmerupakan kendaraan rel yang dapat bergerak sendiri berfungsi sebagai penggerak rangkaiankereta atau gerbong. Lokomotif di Indonesia khususnya di Pulau Jawa mempunyai bebangandar dan jarak gandar yang berbeda-beda, sehingga hal ini mengakibatkan terjadinyaperubahan gaya dalam yang bekerja pada struktur jalan rel kereta api. Beban hidup yangbekerja pada struktur atas jembatan kereta api adalah beban yang berasal dari rangkaian keretaapi yang besarnya ditentukan berdasarkan skema pembebanan Rencana Muatan 1921 (RM1921). Dengan RM 1921 yang sudah ditetapkan sebagai peraturan Jembatan yang dilalui olehrangkaian kereta api yang melintas maka pada suatu titik tertentu pada jembatan gelagarmemanjang akan menimbulkan gaya dalam seperti gaya momen dan lintang yang berubahbesarnya tergantung dari letak rangkaian kereta api. Akan tetapi, kondisi aktual beban gandardan jarak gandar tidak sesuai dengan RM 1921. Untuk mengetahui besarnya gaya dalam(momen maksimum) maka diperlukan suatu perhitungan analisis yaitu menggunakan garispengaruh. Dari hasil perhitungan antara lokomotif aktual dan RM 1921 diperoleh kesimpulangaya dalam (momen) maksimum lokomotif aktual lebih kecil 30,38% dari pada RM 1921, olehkarena itu RM 1921 masih memadai untuk dipakai pada kondisi saat ini.
PEMODELAN NUMERIK 1-D ADVEKSI-DISPERSI UNTUK MEMPREDIKSI KONSTRENTASI POLUTAN DALAM BADAN SUNGAI
Authors: Prasetya Adhita , Yudianto Doddi , Guan Yiquing
Published: May 2022

Abstrak: Peran rekayasa Hidrologi dan Hidrolik dalam pengelolaan lingkungan menjadi amat penting dalam mengatasi permasalahan-permasalahan polutan di area perairan. Seperti telah kita ketahui bersama, pengujian kualitas air sungai membutuhkan biaya dan waktu yang cukup lama, selain itu untuk memperoleh informasi areal terpapar polutan tertentu sering kali mengalami kendala. Studi ini mencoba untuk mengatasi beberapa keterbatasan tersebut diatas dengan cara membuat pemodelan numeric 1-D adveksi-dispersi yang bertujuan untuk memprediksi konsenta-si polutan dalam badan sungai. Model numerik yang dikembangkan bertujuan untuk mempred-iksi transportasi massal kontaminan di badan sungai. Dalam melakukan analisa, metode yang digunakan adalah analisis 1 dimensi dan metode numerik menggunakan skema lax-wendroff . selain itu untuk memudahkan dalam pemodelan, dibuat model sungai rectangular dengan lebar saluran (B) 8 m, tinggi muka air (H) =0,4 m, kemiringan sungai ( so) = 0.00005, dan panjang saluran (L) = 150 km, serta dasar saluran adalah beton. Untuk mesimulasikan konsentrasi menggunakan finite difference schemes pada jarak 50 s.d 100 km, software yang digunakan ada-lah MATLAB serta menggunakan skema Lax-Wendroff (LW) untuk memecahkan Persamaan 1D Adveksi-Dispersi. Dari hasil pemodelan dapat disimpulkan terjadi pelebaran kurva konsen-trasi polutan akibat pengaruh dari hidrolika. Pada saat konsentrasi polutan tertinggi berada 50 km dari lokasi pembuangan limbah, area terpapar polutan 40 – 60 km, sedangkan pada jarak 100 km dari lokasi pembuangan limbah, area yang terpapar oleh polutan 80 – 120 km .
EIGENVALUE LINEAR BUCKLING OPTIMIZATION OF MODIFIED OPEN WEB STEEL JOIST
Authors: Ardianto Johan
Published: May 2022

Abstract: Open web steel joist (OWSJ) is a lightweight beam structural system that is widely used since the 1900s. It generally composed by T section as flanges on top and bottom, and L sec-tion as an open web on the centre. However, many modifications of OWSJ is commonly seen in construction sites, one of them is the usage of channel sections as top and bottom flange, and rebar steel as the open web. This configuration is mainly used to reduce cost and ease the material sup-ply. The modified OWSJ have potential to act differently than the regular one, hence scientific study need to performed to know the behaviour of the modified system. In this paper, comparison on analytical and finite element approach is conducted. The analytical method is done by mechani-cal calculation assuming there are no buckling of the flanges, web rebars are calculated individual-ly. In real structure, buckling may occur and web rebars also work concurrently. Therefore, finite element analysis with LUSAS software is conducted. The purpose of this research is to know the behaviour of OWSJ in FEM analysis. Result displays lateral torsional buckling is happen and to overcome this problem, gradation of web size is tested, resulting maximum of 10.6 % increase in capacity.
Influence of Gravel as Protection Layer on the Filter Run Time
Authors: Anggraini Agustina Kiky , Fuchs Stephan
Published: May 2022

Abstract: Since the beginning of the usage of slow sand filter (SSF) as one of the water treat-ment technologies, studies on how to enhance the performance have been conducted to date. One of the limitations in the current knowledge is regarding the method to increase the filter run time. The addition of protection layer may extend the filter run time. This paper focuses on the influence of gravel as the protection layer to the filter run time and turbidity removal. Gravel was chosen as the material of protection layer because of its low-cost and availability. A system-atic investigation by comparing only one different factor within the filter, which was protection layer, was conducted under the laboratory scale. The experimentconsisted of two filter columns namely K1 and K2. Both filters were constructed using the same filter depth, type of sand, and grain size distribution. The protection layer was added to filter K1, but not to filter K2. The sol-ids penetration and the increase of filter head loss wasused to evaluate the filter run time. A sta-tistical analysis was also carried out to examine the difference on the turbidity removal from both filters. The findings showed that by adding the protection layer, the filter run time could be extended up to 70%. Regarding to the turbidityremoval, there was insignificant difference between two filters.
KAJIAN INFRASTRUKTUR DAN SEMPADAN SUNGAI PADA WILAYAH RAWAN BANJIR LAHAR DI SUNGAI PROGO HILIR
Authors: Ikhsan Jazaul , Anjasmara Krisna Bagus
Published: May 2022

Progo River is one of the rivers that originated in Merapi Mountain. It is one of the active volcanoes, and if it erupted, so it resulted in an abundant material or sediment. The material from its eruption transported by water discharge will become a debris flow, that it gave damage and losses on infrastructure and inhabitants living around riparian areas. Based on the background, therefore, it is essential to do a research-related infrastructure and population in a riparian zone. The research objective is to study the accordance of the condition of the riparian zone of downstream Progo River based on the established rules. The method used was a field survey assissted by the application of Survey123 for ArcGIS. The data processing used ArcGIS software. The research result shows that some locations are not by the established rules on riparian areas. One of the most significant places having the highest settlement percentage included in riparian areas is Jatisarono Village Nanggulan Subdistrict, with the area of settlement of 0.1224 km square and 44.07% for the riparian zone with 50 m width and 0.1766 km square while 21.16% for the riparian zone with 100 m width. Jatisarono village also becomes the village with the highest approximate population number within the riparian zones with 135 people in the riparian zone with 50 m width and 195 people the riparian zone with 100 m width. From the field survey result, it finds that 13 rivers infrastructures along the downstream Progo River consisting of 10 bridges, two dams, and one groundsill (sample) are still in reasonable good condition.
Rancangan Saluran Tebuka pada Sistem Penyaliran Tambang di PT Hasnur Riung Sinergi Jobsite PT Bhumi Rantau Energi, Kabupaten Tapin, Provinsi Kalimantan Selatan
Authors: Atok Roy Andrew Ericson , Adnyano A. A. Inung Arie
Published: May 2022

PT Hasnur Riung Sinergi conducts coal mining using the open pit method, so that mining activities are directly related to outside. The problem is condition of the trench that unable to drain run off, so that makes overflows and inundates the roads and other mining areas. The research aims to design a trench that able to drain the planned run off and calculate the cost of making a trench. The method used is to calculate run off flow to determine the dimensions of the trench, then calculate the productivity of the machine to determine the cost of fuel requirements and the wages of the heavy equipment operator in making the trench. Based on the analysis of rainfall data obtained rainfall intensity of 53.58 mm/hour. There are 7 catchment areas that produce different amounts of run off. Design of a trapezoidal trench for each DTH, the trench on DTH 1, DTH 2, DTH 3, DTH 4 will be made in the pit and useful for flowing run off into the pit leading to the sump, while the trench on DTH 5, DTH 6, DTH 7 will be made outside the pit and useful for flowing run off that is outside the pit to the settling pond. The trench manufacturing work requires 2 PC200 komatsu backhoe machines with excavation time of 11 days. The cost to purchase fuel is Rp.27.846.000 and the cost to pay the operator is Rp.2.970.000. The total cost required for the work of making trenches is Rp.30.456.000. The design was made as a reference for companies in making trenches in the mining area to control run off so as not to interfere with mining activities.