bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of LHS-1269 on morphology and angiogenesis of Lewis lung carcinoma
Authors: Merkulova I. B. , Golubeva I. S. , Khochenkov D. А. , Abramova T. V. , Ermakova N. P. , Ektova L. V.
Published: December 2022

Background. The new anticancer chemical compound LHS-1269 from the class of indolocarbazoles is undergoing preclinical studies at the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia. LHS-1269 has a high antitumor activity on transplanted tumors of mice, showed high cytotoxic activity on many tumor cells lines in vitro, and has shown an inhibitory effect on vasculogenic mimicry in tumors in vitro. LHS-1269 does not affect the catalytic activity of human topoisomerases I and IIα. An antiangiogenic mechanism of the drug’s antitumor action is suggested.

Aim. To evaluate the effect of LHS-1269 on the morphological features and angiogenesis of transplanted Lewis lung carcinoma (LLC) in BDF1 mice.

Materials and methods. In BDF1 mice (n = 20) with transplanted LLC tumor on days 1 and 3 after 5-fold intraperitoneal administration of LHS-1269 in a single dose of 60 mg (total dose – 300 mg/kg), mice (n = 20) on days 5 and 8 after a single intravenous injection of LHS-1269 at a dose of 100 mg/kg, mice (n = 20) with transplanted LLC tumor without administration of LHS-1269 (control). The assessment of the antitumor effect was carried out according to the criterion of inhibition of tumor growth (%) and the study of the morphological features of the tumors. To assess the effect of LHS-1269 on tumor angiogenesis in LLC tumor sections, a visual calculation of the average number (density) of blood vessels and immunohistochemical detection of expression of the CD31+ endothelial marker were performed.

Results. The LHS-1269 compound in animal groups with 5-fold and 1-fold use caused tumor growth inhibition – 59–70 and 67–79 %, with pronounced morphological changes and tumor cell death. There is an uneven distribution of blood vessels in tumors and surrounding tissues in all groups. LHS-1269 caused a statistically significant decrease in the average number of blood vessels in the tumor both after 5-fold and after 1-fold administration. The statistically significant decrease in the average number of blood vessels in the surrounding connective tissue tumor was observed only after 5-fold administration of the drug. The decrease in the average number of CD31+ endothelial cells after five times intraperitoneal administration was statistically insignificant compared to control (83.1 ± 8.7 and 59.6 ± 18.9, respectively). The increase in this indicator after a single intravenous injection of LHS-1269 was statistically significant.

Conclusion. LHS-1269, when administered five times and once in mice, caused pronounced morphological changes in the form of damage and death of LLC tumor cells. The results of a study of angiogenesis in a tumor do not allow an unambiguous conclusion about the inhibitory effect of LHS-1269 on angiogenesis in LLC tumors in mice.
Clinical and functional characteristics of the post-COVID period (6-month follow-up)
Authors: Leshchenko I. V. , Glushkova T. V.
Published: December 2022

Respiratory symptoms and functional disorders are registered in patients who suffered from COVID-19 (COronaVIrus Disease 2019). Aim. Clinical and functional evaluation of the respiratory system during 6-month follow-up in patients who had moderate and severe COVID-19. Methods. 80 patients were included in the cohort observational prospective study. Patients were examined in 46 (36 - 60) days from the onset of symptoms of COVID-19 and in 93 (89 - 103) and 180 (135 - 196) days at the 2nd and 3rd stages respectively. At all stages, symptoms, dyspnea level, and quality of life were analyzed using validated questionnaires, and a 6-minute step test was performed. At the 2nd and 3rd stages, we assessed spirometric parameters, total lung capacity, carbon monoxide diffusing capacity (DLCO), and high resolution computed tomography scans of chest organs. Results. At the 1st stage of the study, 62% of patients complained of fatigue, muscle weakness, 61% of patients had dyspnea of variable severity. At the 3rd stage of the study, 43% and 42% of patients had the same complaints respectively. The prevalence of moderate COVID-19 form in patients with 35 (25 - 45)% lung damage and severe COVID-19 form with 75 (62 - 75)% of lung damage was established. At the 2nd stage, a DLCO < 80% level was recorded in 46% of patients with 35 (25 - 45)% lung damage and in 54% of patients with 75 (62 - 75)%. At the 3rd stage, DLCO < 80% was diagnosed in 51.9% and 48.1% of patients with of 35 (25 - 45)% and 75 (62 - 75)% lung damage respectively. The level of DLCO < 60% was found in 38,5% and 35,5% of patients with moderate and severe lung damage at the 2nd and 3rd stages of the study respectively. Conclusion. The symptoms were reported less frequently during the 6-month follow-up after COVID-19. 77% and 87% of patients had DLCO < 80% in 93 (89 - 103) and 180 (135 - 196) days after the disease onset, respectively. 38.5% and 35.5% of those patients, predominantly having suffered COVID-19 in severe form, had DLCO < 60% at 93 (89 - 103) and 180 (135 - 196) days, respectively. This calls for a continuous observation and regular examinations after COVID-19.
Sarcoidosis: federal clinical guidelines for diagnosis and treatment
Authors: Chuchalin A. G. , Avdeev S. N. , Aisanov Z. R. , Baranova O. P. , Borisov S. E. , Geppe N. A. , Vizel’ A. A. , Vizel’ I. Yu. , Zaicev A. A. , Kravchenko N. Y. , Ilkovich M. M. , Lovacheva O. V. , Malakhov A. B. , Malyavin A. G. , Petrov D. V. , Romanov V. V. , Sivokozov I. V. , Samsonova M. V. , Solovieva I. P. , Stepanyan I. E. , Terpigorev S. A. , Tyurin I. E. , Frantsuzevich L. Ya. , Chernyaev A. L. , Shmelev E. I. , Shmeleva N. M.
Published: December 2022

Sarcoidosis is a multi-organ granulomatosis  of unknown  origin. Modern  diagnostic methods  allow detecting  this disease at an early stage. The absence of specific markers requires a comprehensive  approach  to diagnosis based on comparison  of radiation,  clinical, morphological  and functional data. The course of sarcoidosis without damage to the respiratory system presents significant difficulties. It is extremely important  to understand the time and means of starting Sarcoidosis’s treatment to avoid the early initiation  of hormones  and cytostatics and, on the other hand,  to timely respond to progression and threatening  conditions.  Methods. Clinical recommendations are based on the analysis of Russian and English publications of the latest sarcoidosis research. The target audience of these clinical guidelines are therapists, general practitioners, pulmonologists, TB doctors, rheumatologists,  dermatologists,  radiation diagnosticians,  immunologists,  and clinical pharmacologists.  Each thesis-recommendation for diagnosis and treatment is evaluated on an 1 to 5 scale of levels of evidence and an A, B, C scale of the grades of recommendations. The clinical guidelines also contain comments and explanations for the theses-recommendations, diagnostic algorithms, treatment strategies, reference materials on the use of recommended drugs. Conclusion. Current information  on epidemiology, clinical manifestations,  diagnosis and management  strategies for patients with sarcoidosis are covered in the presented clinical guidelines. Approved by the decision of the Scientific and Practical Council of the Ministry of Health of the Russian Federation (2022).
Hyaluronic acid as a predictor of exacerbation of occupational chronic obstructive pulmonary disease
Authors: Fedotov V. D. , Khlystov A. C. , Blinova T. V. , Strakhova L. A. , Lavrenyuk N. A. , Dobrotina I. S.
Published: December 2022

The frequency of exacerbations of chronic obstructive pulmonary disease (COPD) is one of the main factors determining the outcome. The search for biomarkers which reflect the risk of exacerbations is one of the urgent scientific and practical objectives. Aim. The study aimed to analyze the relationship between the serum concentration of hyaluronic acid (HA) and the frequency of exacerbations of occupational COPD caused by exposure to silica dust and to substantiate the use of HA as a predictor of exacerbations of COPD. Methods. 78 individuals with a diagnosis of occupational COPD were examined. Respiratory function was assessed based on forced vital capacity of the lungs (FVC, %), the forced expiratory volume in 1 second (FEV1, %) and the calculated ratio of these parameters (FEV1/FVC, %), i.e., modified Tiffno index. The serum concentration of hyaluronic acid (ng/ml) was determined in all individuals using solid-phase enzyme-linked immunosorbent assay (ELISA). The absolute blood level of eosinophils (cell/μl) was determined by a unified method of morphological study of hemocytes with white blood cell differential count. Results. Serum HA concentration in patients with occupational COPD with frequent exacerbations was 25% higher than in the patients with rare exacerbations (the difference was statistically significant; р = 0,004). The analysis of the obtained data showed that the most significant moderate correlation was found between the level of HA and the frequency of COPD exacerbations (direct relationship, r = 0.32; p < 0.05), and FEV1 and the frequency of COPD exacerbations (feedback, r = -0.32;p < 0.05). A weak relationship was found between the relative number of eosinophils and the frequency of COPD exacerbations (direct relationship, r = 0.2; p < 0.05). Weak correlations were also found between the level of HA and FEV1 (feedback, r = -0.23; p < 0.05), between the level of HA and the relative number of eosinophils (direct relationship, r = 0.18; p < 0.05). Conclusion. Quantitative analysis of serum HA in patients with occupational COPD can be used in clinical practice as a biochemical marker for assessing the risk of exacerbations and progression of bronchopulmonary pathology.
Analysis of the effectiveness of smoking cessation in patients with pulmonary tuberculosis in a hospital setting
Authors: Chumovatov N. V. , Antonov N. S. , Sakharova G. M. , Chernyh N. A. , Romanov V. V. , Ergeshov A. Е. , Rusakova L. I.
Published: December 2022

According to the WHO, tobacco use is currently the leading cause (16%) of all adult deaths. Studies conducted in many countries and in the Russian Federation have revealed the association between smoking and pulmonary tuberculosis (PT). Due to the negative impact of tobacco smoking on the course of tuberculosis and the effectiveness of treatment, there is a need to develop approaches to smoking cessation in patients with PT. Aim. To evaluate the effectiveness of the treatment of PT in smoking patients in combination with nicotine replacement therapy in an inpatient setting. Methods. The study included 27 patients with a confirmed diagnosis of PT. The inclusion criteria for the study were: age 18 years and older, patients who are currently active smokers, and a confirmed diagnosis of PT. The exclusion criteria were the presence of asthma and oncological diseases, unconfirmed diagnosis of PT, and earlier history of tobacco use. In the study group, an analysis of the smoking status was carried out. This status was based on the length of smoking period, number of cigarettes per day, and calculation of the smoking patient index. The degree of nicotine addiction, the presence of withdrawal symptoms, and the motivation of patients to quit smoking were assessed. The principle of nicotine dependence treatment was to prescribe nicotine-containing drugs in a dose depending on the degree of nicotine addiction. The duration of treatment was 12 weeks. Results. After 4 months of PT treatment, the cessation of bacterial excretion was detected 2 times more often, the closure of decay cavities in the lung tissue - 2.5 times more often, the relief of systemic inflammatory reactions - 2 times more often in patients who quit smoking than in patients who continue to smoke. Conclusion. This study showed that the treatment of PT in smokers was more effective in combination with nicotine replacement therapy for smoking cessation than when the patients continued to smoke.
Lung transplantation in a patient with α1-antitrypsin deficiency emphysema
Authors: Karchevskaya N. A. , Kevorkova M. S. , Tarabrin E. А. , Kallagov T. Е. , Ibavov I. U. , Pervakova E. I. , Cherniaev A. L. , Samsonova M. V. , Khubutiya M. Sh. , Chuchalin A. G.
Published: December 2022

The condition of patients with chronic lung diseases is gradually deteriorating despite modern drug therapy and often progresses to severe respiratory failure. Thus, it is important to consider other options, including surgical methods, to help such patients. The aim of the study is to demonstrate potential additional pharmacological and surgical treatment algorithms for chronic obstructive pulmonary disease (COPD) associated with α1-anti-trypsin (A1AT) deficiency. Results. The analysis of long-term medical history (from the onset to the terminal stage of the respiratory failure) of a patient with A1AT deficiency was performed. Conclusion. Patients with COPD associated with A1AT deficiency require combination inhaled controller therapy and augmentation therapy with a1-proteinase inhibitor. Patients with terminal stage of the disease need lung transplantation unless they have any contraindications.
Bilateral staged anatomic lung resection for bronchiectasis and infected polycystic disease complicated by bleeding: viability with 3 hypertrophied segments maintained
Authors: Benyan A. S. , Medvedchikov-Ardiia M. A. , Abashkin N. Yu.
Published: December 2022

Bilateral lung resections are performed  for various pathologies: pulmonary  emphysema,  parasitic diseases, metastatic  lesions, and bronchiectasis. In clinical practice, sequential or staged interventions  are more common.  Surgical treatment of bronchiectasis is currently carried out only in cases with complications  of localized forms and, as a rule, consists of resection of the affected part of the lung. The percentage of such patients is not large and amounts to about 5%. Taking into account the chronic course of bronchiectasis and certain successes of the conservative treatment, indications for resection operations  may arise at different periods of the patient’s life. Sometimes,  up to several decades can pass between the surgeries. Aim. To demonstrate  a rare clinical case of staged lung resection for bronchiectasis in a patient who had 4 lung lobes removed with an interval of 52 years. Results. History of the disease was described. Indications  for staged surgical interventions  were identified. The main characteristics  of the health status after the surgeries were described. Conclusion. The presented case illustrates the place and role of surgical methods in the treatment of bronchiectasis, as well as the compensatory  capabilities of the lung tissue in the case of staged resection interventions.
Comorbidities in patients with chronic obstructive lung disease and COVID-19 in Almaty (Kazakhstan Republic)
Authors: Esetova G. U. , Idrisova L. R. , Salimova S. S. , Konysbay B. , Batyrbay D. , Muminov T. A.
Published: December 2022

SARS-CoV-2 (Severe Acute Respiratory Syndrome-related CoronaVirus 2) infection is characterized by multi-comorbidity, which increases the severity of the disease. The aim of the study was to identify the relationship between the length of stay in the hospital and the comorbidity and the severity of lung damage. Methods. 72 patients with COVID-19 (COronaVIrus Disease 2019) infection were studied, including 33 women and 39 men who were treated in the city hospitals. The average age was 67.4 ± 12.02 years. The SARS-CoV-2 RNA virus was identified by PCR in 46 (63.8%) patients. Results. The most common comorbidities in chronic obstructive pulmonary disease (COPD) patients with COVID-19 included arterial hypertension (in 32%), coronary artery disease (17%), and type 2 diabetes (10%). The majority of patients (48.7%) had the CT II stage. The total proportion of patients with an advanced damage (corresponding to CT III - IV) was 36.2%. Mean hospitalization length was 13.8 ± 7.9 days. Conclusion. COPD patients with COVID-19 infection included a significant percentage of patients with arterial hypertension, which required additional treatment.
Antimicrobial and Antioxidant Potential of Silver Nanoparticles Synthesized from Primula vulgaris
Authors: ERDEM Belgin , ÇİFTÇİ Harun , ŞAHİN Yunus
Published: December 2022

In this study, biosynthesis and in vitro phytochemical composition, antibacterial and antioxidant activities of silver nanoparticles were investigated by using aqueous leaf, flower and root extracts of Primula vulgaris (P. vulgaris subsp. vulgaris). The synthesized silver nanoparticles (AgNPs) were confirmed by color conversion and ultraviolet-visible (UV-visible) spectrophotometry. The appearance of a dark brown color and a UV absorption spectrum range at 440 nm confirmed the synthesized silver nanoparticles. The antimicrobial activity of silver nanoparticles synthesized from the leaf of P. vulgaris; S. aureus 25±1, S. epidermidis 20±1, P. aeruginosa 20±1, A. hydrophila 21±1, C. albicans 25±1, C. tropicalis 25±1, C. parapsilosis 22±1 and C. glabrata 20±1 mm zone diameter was determined. The most antimicrobial effect of P. vulgaris leaf aqueous extract; S. aureus 20±1, S. epidermidis 18±1, A.hydrophila 15±1, P. aeruginosa 12±2, C. albicans 18±1, C. glabrata 18±1, C.tropicalis15±2, and C. parapsilosis 15±2 mm zone diameter was revealed. The presence of flavonoids, terpenoids, protein, and carbohydrates was found to be higher in silver nanoparticles synthesized in the flower part of P. vulgaris, according to phytochemical screening. While saponins were detected in P. vulgaris root extracts, tannins and protein were detected in the leaf extract. The flower had the highest total phenolic extract content of the silver nanoparticle (29.08±0 mg GAE/g DW), while the leaf and root had the lowest total phenolic content of 9.06±0.5 and 8.64±3.3 mg GAE/g DW, respectively. The flower had the highest total phenolic extract content of the plant aqueous extracts (25.10±0.2 mg GAE/g DW), while the leaf and root had the lowest (8.28±0.5 and 5.20±0.0 mg GAE/g DW, respectively).The DPPH (1,1-Diphenyl-2-picrylhydrazil) assay was used to assess free radical scavenging activity. The antioxidant activity of AgNPs biosynthesized using P. vulgaris flower extract was 90.6 %, while P. vulgaris flower aqueous extracts were 86.3 %.
This can be concluded that silver nanoparticles synthesized using P. vulgaris flower extract are useful in the preparation of pharmacologically useful drugs.
BENCHMARKING COMO ESTRATÉGIA PARA A MELHORIA DOS PROCESSOS NO LABORATÓRIO CLÍNICO
Authors: Da Silva Flavia Patricio
Published: December 2022

Na busca pela melhoria continua de seus processos, laboratórios clínicos, visando atender as normativas do segmento e tornarem-se mais competitivos pela qualificação do serviço, adotam práticas de mensuração de desempenho e comparação com outras empresas, formalmente e informalmente.  Este estudo trata-se de uma pesquisa descritiva e exploratória, com abordagem qualitativa e quantitativa, realizada com sete laboratórios do estado de SC. Objetivando debater o modo com que os gestores analisam o desempenho organizacional do laboratório clinico, bem como praticam a troca de informações entre laboratórios.
Comparative analysis of anthocyanin content in various tomato samples in connection with breeding
Authors: Dzhos E. A. , Mamedov M. I. , Pyshnaya O. N. , Golubkina N. A. , Verba O. V. , Matyukina A. A.
Published: December 2022

Relevance. Anthocyanin pigments can be synthesised in the stem, leaves, calyx, peel and pulp of tomato fruit. These compounds protect the photosynthetic apparatus of the plant, neutralise free radicals, increase the efficiency of phosphorus and nitrogen assimilation, have an osmoregulatory function, antimicrobial activity and increase the level of adaptation to unfavourable environmental conditions. In addition, anthocyanins from plant foods play an important role in the prevention of type II diabetes, neurodegenerative processes, cardiovascular and infectious diseases. Therefore, the cultivation of tomatoes with anthocyanin-coloured fruits is a perspective area for the vegetable industry in Russia. Vegetable products containing antioxidant substances belong to the functional products and conform to the concept of a healthy diet. As one of the most popular and frequently consumed vegetable crops, the anthocyanin content of tomato is advisable to increase in the fruit (peel and pulp).

Material and methods. In this work we studied breeding samples of FSBSI FSVC: L-Ch-365, L-IR-2080, L-Zemba, hybrid combination F1 Zemba x L-Ch-365, variety of Siberian Botanical Garden Bosare blue. The aim of our research was to determine the quantitative composition of phenolic compounds - anthocyanins in different tomato samples, and on this basis to determine the objectives of breeding to improve the content of phenolic compounds.

Results. As a result of the research, the quantitative content of anthocyanins in fruits of dif- ferent tomato specimens has been studied, on which the dietary and medicinal quality of the fruits depends. The sources of high content of anthocyanins (L-Zemba, L-IR-2080) have been obtained, which will make possible to conduct directed breeding work for high content of phenolic compounds. It has been shown that anthocyanin-rich tomato samples can be rich in carotenoids, which gives an opportunity to create new varieties and hybrids with high content of water- and fat-soluble antioxidants. Potential samples for breeding according to the complex of biochemical indicators have been identified: L-Zemba, L-IR-2080, Bosare blue. It has been shown that selection for high content of anthocyanins can be performed at various stages of fruit ripening (large ripe fruit, blangetongue, biological ripeness), selecting the most intense colouring. The Zemba tomato variety developed at FSBSI FSVC has a sufficiently high anthocyanin content and is recommended for cultivation in production.
Regenerative ability and micropropagation of Petunia hybrid in vitro
Authors: Borovaya S. A. , Boginskaya N. G.
Published: December 2022

Scientific relevance. The garden petunia,Petunia hybrida, is a popular and wide spread ornamental crop from the family Solanaceae. It is a promising model plant for molecular and genetic research.In vitromicropropagation plays an important role in the distribution of the garden petunia because the survivability and quality of seed material decreases significantly in every subsequent generation. Besides, micropropagation reduces the cost of production substantially. Considering that very few researchers addressed this question in the Russian Federation, this direction of research is still worthy of attention.

Materials and methods. The experiments were conducted by the Laboratory of Breeding and Genetic Research on Field Crops at FSBSI “Federal Scientific Center of Agricultural Biotechnology of the Far East named after A.K. Chaiki”. Seeds ofPetunia hybrida(double-flowered) were used as primary explants. Liquid bleacher ACE diluted with distilled water in the proportion 1:9 was used as a sterilizing agent (the working solution contained 0.50% NaOCl). The total time of exposure was 15 minutes. The primary explants were subcultured onto a hormone-free Murashige and Skoog basal medium containing 20 g/L sucrose and 6 g/L agar. Isolatedin vitroobjects were cultured in test tubes with cotton-gauze plugs at an illuminance of 4000 lx, a temperature of 22–25 °C, and a 16h photoperiod in a culture room. The duration of one passage was 60 days. Micropropagation was carried out using 7- 10 mm cuttings with one or two nodes. The pot culture of the regenerants was established under controlled conditions in a light room (photoperiod was 16 hours, temperature was 23°С).

Results. The optimal method for introducingPetunia hybridainto cell culture is the use of seeds treated with the solution of bleacher ACE that was diluted with distilled water in the proportion 1:9. The optimal time of exposure is 15 minutes.Petunia hybridademonstrated a high regeneration rate on the hormone-free MS medium – it had a fast growth and development rate, and good rhizogenesis; the reproductive rate was 8.77. For the micropropagation of the garden petunia, it is advisable to use cuttings of test tube plants, which should be placed onto a hormone-free MS medium. The test tube plants ofPetunia hybrida acclimatized successfully on a soil substrate. This shows the high plasticity of the culture.
Analysis of cabbage production in Russia
Authors: Razin O. A. , Surikhina T. N.
Published: December 2022

Relevance. The article analyzes the indicators of white cabbage production in Russia (by districts, subjects of the federation and categories of farms).

Methodology. The object of research is the market for the production of white cabbage. The subject of the study is the current state of white cabbage production. The information base of the study was made up of data from FAO, official state statistics, the Federal Customs Service, the Ministry of Agriculture of the Russian Federation, the Ministry of Finance of the Russian Federation, Parliamentary hearings of the State Duma Committee on Agrarian Issues, the Eurasian Economic Union, the Eurasian Economic Commission, operational online messages of federal and regional levels, materials of periodicals, scientific seminars, conferences, symposiums, reflecting various aspects of the problem under study.

Results. In the industrial sector of vegetable growing, the acreage of cabbage of all types in 2021, in relation to 2020, decreased by 15.8%. Over the past ten years, there has been a decrease in acreage and gross cabbage harvest in farms of all categories. There are a number of systemic problems in Russian vegetable growing that limit the increase in vegetable production and negatively affect its effectiveness: weak technical and material equipment of a significant part of farms engaged in vegetable production, outdated technical base, insufficient provision of crops with seeds of domestic production. One of the leading roles in the implementation of the policy of food security and national independence is played by the selection and seed production of white cabbage. Sanctions make it possible to carry out import substitution of varieties and hybrids of white cabbage. To date, the main task is to abandon the import of seeds of foreign selection, and therefore it is important to focus on creating new hybrids that will be of high quality, good yield, as well as resistance to diseases and pests. Modern hybrids of breeding FGBNU FNTSO and Agrofirm "Poisk" according to the results of testing in leading agricultural organizations fully meet the requirements of the market and can take a worthy place in the fields in the Russian Federation.
Binā al-Jumal al-Mu’aqqodah fī Riwayah “Mā Lā Nabūh Bih” ala Asāsi Nadhariyyati Tagmemic Kenneth L. Pike [Complex Sentence Construction in Novel “Mā Lā Nabūh Bih” Based on the Perspective of Kenneth L. Pike’s Tagmemic]
Authors: Basid Abdul , Syafina Hanna Izzah , Hayati Husnizan , Nazir Husni , Razi Fakhrur
Published: December 2022

Sentence studies that are rarely discussed in the realm of linguistics are complex sentences. This article aims to describe the construction and types of complex sentences based on their clause formation in the novel Mā Lā Nabūh Bih based on Kenneth L. Pike's Tagmemic theory. This research was a qualitative and descriptive study, with the primary data source were the novel Mā Lā Nabūh Bih by Sandra Serag. Each type of complex sentence was selected and described according to Tagmemic theory. The results of this study found that four ‘harf’ functions were used as subordinating conjunctions based on the formation of the clauses, which consists of the arrangement of musnad (subject), musnad ilaih (predicate), and maf'ul bih (object). The distinguishes among four ‘harf’ functions are in the form and position of the subordinating conjunctions that separate the main sentence and its subordinate clauses, namely time relations (mundzu/since), causal relationship (lianna/because), complementary relationships (anna/really), comparative relationship (kaanna/as if). Complex sentences in the Tagmemic perspective are more complex than other types of sentence structures since they may consist of two slots, two classes, two roles, or two cohesions. In contrast, other sentence structure types have only one slot, class, role, and cohesion.
Gerakan Women’s March Indonesia dengan Amerika Serikat sebagai Aksi Solidaritas Sesama Perempuan Tahun 2017
Authors: Meivio Bahari Raden Arief , Aditiany Savitri , Rifawan Affabile
Published: December 2022

Gerakan Women’s March yang pertama kali muncul pada 4 Maret 2017 di Indonesia. Gerakan ini terjadi karena terdapat banyak isu kesenjangan antara perempuan dan laki-laki, seperti adanya kasus pelecehan atau kekerasan dan masalah kesetaraan gender. Gerakan Women’s March di Indonesia menjadi salah satu Sister Marches dari Women’s March di Amerika Serikat. Riset ini dilakukan dengan metode riset kualitatif dengan analisis deskriptif, serta dengan menggunakan teori feminisme. Hasil riset ini menunjukkan bahwa Women’s March di Indonesia sudah ada dan dilaksanakan dari tahun 2017 hingga 2021 yang merupakan bagian dari gerakan feminisme setelah era reformasi, dan sebagai bagian dari gerakan feminisme gelombang keempat yang berkaitan dengan feminisme dalam ranah Hubungan Internasional. Dalam hal ini, dengan adanya globalisasi yang menyebar tanpa kenal batas wilayah, maka Women’s March berkonvergensi menjadi gerakan transnasional yang membumikan isu nasional khususnya di Indonesia. Women’s March menjadi gerakan sisterhood dengan gerakan yang sama di Washington 2017, dan sisterhood dengan gerakan Women’s March yang ada di kabupaten atau kota di Indonesia.
Tantangan Strategis Indonesia ditengah Rivalitas Tiongkok versus AUKUS: Sebuah Analisis Dilema Tahanan
Authors: Walesasi Yoggi , Suharman Yoga , Mappiare Andi
Published: December 2022

Aliansi pertahanan trilateral yang melibatkan Australia, Inggris dan Amerika Serikat (AS) (AUKUS) dalam pengadaan kapal selam bertenaga nuklir memicu reaksi dari negara-negara di sekitar kawasan, termasuk Indonesia sebagai negara paling strategis di Indo-Pasifik. Sebagai salah satu kekuatan poros di Indo-Pasifik, Indonesia sendiri berada di posisi dilema diantara dua poros kekuatan besar, AUKUS dan Tiongkok yang saling berkontestasi pengaruh. Tulisan ini bertujuan untuk mengkaji bagaimana tantangan kebijakan luar negeri Indonesia atas rivalitas geopolitik yang menempatkan Tiongkok berhadapan dengan AUKUS. Guna menjawab pertanyaan itu, tulisan ini meminjam pendekatan dilema tahanan sebagai alat analisis untuk mengurai persoalan yang dihadapi oleh Indonesia dalam menentukan preferensi politik luar negerinya atas pembentukan aliansi pertahanan trilateral AUKUS. Tulisan ilmiah ini disajikan dengan menggunakan metode analisis deskriptif yang diolah dari studi kepustakaan. Hasilnya menunjukkan bahwa Indonesia ada di posisi yang dilematis dalam mempertahankan kepentingan nasionalnya dan terperangkap ke dalam potensi pembelotan dan tekanan dari pihak-pihak yang sedang bersaing.
Melampaui Pahlawan Devisa: Peran Aktor Negara dan Non-Negara Menyasar Permasalahan Finansial PMI Perempuan di Taiwan
Authors: Nuryananda Praja Firdaus , Rikza Ayu , Utami Wulan Anggit , Anggresta Pujana
Published: December 2022

Penelitian ini berusaha meninjau lebih jauh apakah kontribusi remitansi dalam bentuk devisa kepada negara berkontribusi yang sama pada perekonomian individu pasca kerja. Penelitian terdahulu menunjukkan permasalahan yang meliputi proses reintegrasi eks-PMI pasca kepulangan mereka, diantaranya adalah potensi jatuhnya eks-PMI ke kemiskinan dan akhirnya membawa eks-PMI pada keputusan bekerja kembali ke luar negeri. Permasalahan ini jika ditinjau secara struktural menyasar pada sistem yang melayani dan melanggengkan ketimpangan yang dihadapi oleh kelas pekerja. Penelitian ini mengurai aspek agensi yang melatarbelakangi kemiskinan pasca kerja eks-PMI. Penelitian ini menunjukkan bahwa kemampuan keuangan dan kewirausahaan memainkan faktor dalam mencegah PMI jatuh pada kemiskinan dan jerat industri migran. Dari studi kualitatif yang dilaksanakan, penelitian ini mengungkapkan bahwa kehadiran aktor non-negara memiliki peran membentuk kapasitas perempuan PMI yang cenderung altruis dalam mengelola keuangan mereka sebagai basis agensi finansial mereka. Kontribusi penting penelitian ini terhadap penelitian yang terdahulu adalah skema pendidikan keuangan non-formal bagi PMI yang berlangsung di host country selama periode kerja mereka sehingga PMI memperoleh transfer of skill and knowledge yang mereka memungkinkan untuk merencanakan keputusan ekonomi dengan lebih baik.
Counter-Hegemony Front National Prancis terhadap Hegemoni Transnational Capital Class di Eropa
Authors: Sedono Equanjana Fatah , Choiruzzad Shofwan Al Banna
Published: December 2022

Integrasi di Eropa merupakan proyek yang dibentuk oleh suatu hegemoni transnasional. Hegemoni ini telah menyebabkan krisis sehingga menimbulkan penolakan dari kelompok sayap kanan seperti Front National di Prancis. Penelitian ini akan menjelaskan terjadinya counter-hegemony dari Front National terhadap hegemoni Transnational Capital Class di Eropa. Tulisan ini akan menggunakan pendekatan Cultural Hegemony Gramscian untuk melihat bagaimana hegemoni yang dibentuk oleh Transnational Capital Class menimbulkan dimensi krisis sehingga mendorong penolakan dari kelompok sayap kanan seperti Front National. European Roundtable for Industry sebagai manifestasi dari Transnational Capital Class memiliki kemampuan untuk mengelola modal transnasional untuk mereproduksi nilai hegemoni walaupun telah terjadi krisis akibat akumulasi modal yang berlebih. Krisis ekonomi di Eropa kemudian menyebabkan berkurangnya dukungan terhadap legitimasi Uni Eropa di Prancis. Dengan menggunakan metode kualitatif deduktif dan pengumpulan data melalui studi literatur, penelitian ini berargumen bahwa terjadinya penolakan dari Front National terhadap hegemoni Transnational Capital Class dan integrasi di Eropa didorong oleh krisis eurozone serta krisis legitimasi Uni Eropa.
Gender Inequality: African Union Strategy to Combat Women Poverty Crisis in Somalia
Authors: Ruslan Izzah Atirah
Published: December 2022

Globalization has led to national security issues to occurred and resulted in people losing their fundamental human rights in some cases. Women’s poverty is clearly the deprivation of human rights for both women and young girls. Somalia, one of the nations in Africa regions, has suffered from the act of gender inequality that deprived the rights of women which led them to live in poverty. Social norms or traditions are playing a crucial role in worsening the condition of living hood among women in Somalia. While both men and women are indeed suffered poverty, however, men are getting wide chances to access job opportunities compared to women. However, in recent years, African Union has acknowledged the importance of women’s role in the economic development of the region, therefore African Union established the Gender Equality and Women’s Empowerment Strategy as a guide to both the government of the states and women’s agency to spread awareness regarding the rights of the women to be equal as men. Therefore, this paper further will discuss how successful such strategies are to be able to construct new ideas and social norms in Somalia.
Global Inequality and Poverty Crisis: ASEAN Ineffective Role in the Mekong River Conflict Resolution
Authors: MOHD ISA NOR ATIQAH
Published: December 2022

Mekong River, known as the beating heart of mainland Southeast Asia, has been facing degradation of its natural flow of water due to anthropogenic activities across the river initiated by the Chinese government through the construction of hydropower dams. As a consequence, the river which provides a key source of water supplies and resources for the millions of people who live across its watershed has suffered significantly resulting in inequality and poverty in the community. The purpose of this study is to examine the root causes of inequality and poverty in the Lower Mekong region, as well as to identify ASEAN’s role in responding to the situation. The findings revealed that due to the Belt and Road Initiative (BRI) projects through the construction of dams along the river as well as ASEAN’s inability to resolve and address the crisis owing to economic dependence and difficulty to reach a consensus among its members has been a contributing factor to the ineffectiveness of ASEAN in the conflict resolution. From the findings, it can be concluded that China’s financial hegemony over the Mekong countries can have an impact on the region’s future levels of poverty and inequality.
COMMUNICATIVE LANGUAGE TEACHING APPROACH IN PROMOTING THE LINGUISTIC COMPETENCE OF EFL LEARNERS
Authors: Berezenko Victoriia , Cherkhava Olesya , Musiienko Yulia
Published: December 2022

The article is devoted to the problems of foreign language education in linguistic universities, namely to promoting the students’ linguistic competence, which has been the most urgent in mastering the language as a means of communication. The research prompts the standards to progress the grammatical competence. In the current study, we make a hypothesis that, in contrast to traditional teaching approach, the communicative approach is supposed to be more effective in teaching grammar and helps students to master the language and upgrade their linguistic competence in comprehending and processing spoken and written texts and become professionals after graduating the University. In the experiment two groups of students were involved: one using traditional approach to learning grammar at the classes and the other practising communicative language teaching approach. In total 79 bachelor’s degree students of Kyiv National Linguistic University (Ukraine) took a tentative course in grammar. The current study testifies the effectiveness of the communicative approach to studying grammar structures as a way to develop the linguistic competence of students and to help them to acquire proficiency level for achieving success in real communication.
Rates of and Factors Associated with Exclusive and Any Breastfeeding at Six Months in Canada: An analysis of population-based cross-sectional data
Authors: Ricci Christina , Otterman Victoria , Bennett Terri-Lyn , Metcalfe Stephanie , Darling Elizabeth , Semenic Sonia , Dzakpasu Susie
Published: December 2022

Background
Breastfeeding has many health, economic and environmental benefits for both the infant and pregnant individual. Due to these benefits, the World Health Organization and Health Canada recommend exclusive breastfeeding for the first six months of life. The purpose of this study is to examine the prevalence of exclusive and any breastfeeding in Canada for at least six months, and factors associated with breastfeeding cessation prior to six months.
Methods
We performed a secondary analysis of breastfeeding-related questions asked on the cross-sectional 2017–2018 Canadian Community Health Survey. Our sample comprised 4,845 females aged 15–55 who had given birth in the five years preceding the survey. Descriptive statistics were carried out to assess the proportion of females exclusively breastfeeding and doing any breastfeeding for at least six months by demographic and behavioural factors. We also assessed, by baby’s age, trends in the introduction of solids and liquids, breastfeeding cessation and the reasons females stopped breastfeeding. Multivariate log binominal regression was used to examine the association between breastfeeding at six months and selected maternal characteristics hypothesized a priori to be associated with breastfeeding behaviour.
Results
Overall, for at least six months, 35.6% (95% confidence interval (CI): 33.3%-37.8%) of females breastfed exclusively and 62.2% (95% CI: 60.0%-64.4%) did any breastfeeding. The largest decline in exclusive breastfeeding occurred in the first month. Factors most strongly associated with breastfeeding for at least six months were having a bachelor’s or higher degree, having a normal body mass index, being married and daily co-sleeping. Insufficient milk supply was given as the most common reason for breastfeeding cessation irrespective of when females stopped breastfeeding.
Conclusion
Six-month exclusive breastfeeding rates in Canada remain below targets set by the World Health Assembly. Continued efforts, including investment in monitoring of breastfeeding rates, are needed to promote and support exclusive breastfeeding, especially among females vulnerable to early cessation.
Hybrid deep learning model for the risk prediction of cognitive impairment in stroke patients
Authors: Wei Zemin , Li Mengqi , Fan Hong
Published: December 2022

Post-stroke cognitive impairment is a common complication of stroke. It reduces the rehabilitation efficacy and disease prognosis of patients. Many factors may be related to cognitive impairment after stroke, including demographic (e.g. age, gender and educational level), history (e.g. hypertension, diabetes, hyperlipidaemia, smoking and drinking) and examination characteristics (e.g. lesion nature, location, side and inflammatory markers). However, most existing methods are qualitative evaluations of independent factors, which ignore the interaction amongst various factors. In addition, no further research on the risk prediction of cognitive impairment after stroke has been conducted. We use a hybrid deep learning model of XGBoost and deep neural network to predict the risk of cognitive impairment in stroke patients for studying the effects of physiological and psychological factors on such a risk. We firstly consider 46 original input features and their cross-product transformation as the interaction amongst binary features, and then, we compare the proposed model with several benchmarks on the basis of various indicators to prove its effectiveness. Lastly, we identify the first 36 factors that affect the risk of fracture in diabetic patients.
Image Generation with Global Photographic Aesthetic Based on Disentangled Generative Adversarial Network
Authors: Zhang Hua , Wang Muwei , Zhang Lingjun , Wu Yifan , Luo Yizhang
Published: December 2022

Global photographic aesthetic image generation aims to ensure that images generated by generative adversarial networks (GANs) contain semantic information and have global aesthetic feelings. Existing image aesthetic generation algorithms are still in the exploratory stage, and images screened or generated by computer have not yet achieved relatively ideal aesthetic quality. In this study, we use existing generative model, StyleGAN, to build the height of image content and put forward a new method based on the GAN disentangled representation of global aesthetic image generation algorithm by mining GANs latent space potential global aesthetic feeling and aesthetic editing of the original image to realize the aesthetic feeling and content of high-quality global aesthetic image generation. In contrast with the traditional aesthetic image generation methods, our method does not need to retrain GANs. Using the existing StyleGAN generation model, by learning a prediction model to score the generated image and the score as a label to learn a support vector machine decision surface, we use the learned decision to edit the original image to get an image with a global aesthetic feeling. This method solves the problems of poor content construction effect and poor global beauty of the aesthetic images generated by the existing methods. Experimental results show that the proposed method greatly increases theprobability of generating ”good-looking” images and aesthetic score of generated images.
Comparison of the psychosocial burden of patients at the beginning of psychosomatic rehabilitation before and during the SARS-CoV-2 pandemic – A multicentric cohort study of routine data
Authors: Körner Mirjam , Johanna Keller , Nalbach Lukas , Röttele Nicole , Rundel Manfred , Bengel Jürgen
Published: December 2022

Background. The study objective is to analyze the influence of the SARS-CoV-2 pandemic on the psychosocial burden of people suffering from mental illness at the beginning of in-patient rehabilitation treatment in Germany
Methods. Psychosocial stress at the beginning of rehabilitation of patient cohorts before or during the pandemic was compared using multivariate variance analyses (MANOVA) and univariate non-parametric Mann-Whitney-U-tests. The study refers to the data of patients from seven psychosomatic rehabilitation clinics of Celenus-Kliniken GmbH.
Results. Based on the sampling of 7335 patients, statistically significant greater stress with a low effect size (η²p = .005) of the cohort affected by the pandemic was observed.
Conclusions. People who started rehabilitation during the pandemic only demonstrated slightly greater psychosocial stress at the beginning of therapy.
Ovipositional/Numerical response of aphidophagous syrphids (Diptera:Syrphidae) at varying prey densities of Lipaphis erysimi and Brevicoryne brassicae (Homoptera:Aphididae)
Authors: Singh Paramveer , Kaur Rabinder , Sharma Sudhendhu , Aggarwal Naveen
Published: December 2022

Background:
Syrphids are well known generalized predators of aphids having remarkable predation potential and proved as effective aphid controlling natural enemies at larval stage. The adult predatory syrphid flies are strong fliers and have ability to travel a long distance to find suitable oviposition site. They select the ovipositioning site as per the prey density and prey species found on the host plant. The oviposition response is remarkably affected with the prey density.
Results:
The present study was focused on the affect of varying prey density on the oviposition behaviour of four predatory syrphid species viz. Ischiodon scutellaris (Fabracius), Episyrphus balteatus(Dee Geer), Eupeodes frequens(Matsmura) and Metasyrphus confrater(Wiedemann) on two prey (aphid) species i.e. Lipaphis erysimi L. and Brevicoryne brassicae L. under laboratory conditions. The results depicting that all the four above mentioned syrphid species showed type II numerical response on both the aphid species with significantly (p<0.0001) negative linear coefficient depicting the decreasing proportion of the number of laid eggs with respect to the increasing prey density. The number of eggs laid by single female of syrphids were increased with respect to increasing prey density until it reached to the upper asymptote and then decreased in the condition of overcrowding of prey.From this study it can be concluded that the site selection for the oviposition by the predatory syrphid flies greatly influenced by the population density of prey (aphids). in the absence of aphids they do not prefer to lay eggs whereas as higher aphid density encourage it to lay eggs until it reached to upper asymptote these results may help in decision making for augmentative release of syrphid flies for establishment of optimum population.