bluuebunny/crossref_metadata_2025 huggingface dataset:
METHODOLOGICAL PRINCIPLES OF IMPLEMENTING ARTIFICIAL INTELLIGENCE INTO ORGANIZATIONAL MANAGEMENT SYSTEM
Authors: Mytrofanova Hanna ,   Alfred Nobel University, Yevtushenko Olha , Hlukhyy Artem , Lugovyy Mykyta ,   Alfred Nobel University,   Alfred Nobel University,   Alfred Nobel University
Published: July 2024

The article examines the theoretical and methodological principles of integrating artificial intelligence into an organization’s management system. It presents a cumulative model illustrating the impact of artificial intelligence on the organization’s management mechanism, which identifies the subjects of influence, tools of influence, directions, and dimensions of influence. Additionally, it describes the challenges posed by the influence of artificial intelligence on the organization’s management mechanism and outlines the main outcomes of this influence. The ways of improving management productivity in various dimensions (socio-technical, strategic-structural, innovative-organizational, task-oriented, information-system) have been systematized. The main results that the use of artificial intelligence offers to the organization have been highlighted, comprising the automation of routine tasks, the reallocation of working time to strategic and creative tasks, increased efficiency in decision-making through analytics and forecasting provided by artificial intelligence, improved external and internal communication, enhanced effectiveness in HR management, formulation of realistic and achievable strategies aligned with future changes, and the development of innovative products and services. An algorithm for introducing artificial intelligence into the organization’s management system has been proposed. The allocation of 8 stages is substantiated as follows: formation of organizational culture; determination of the goals for implementing artificial intelligence; identification of the main performance indicators; establishment of an information base on the state of the management system; analysis of products using artificial intelligence; integration of artificial intelligence products into the management system; monitoring the results of artificial intelligence implementation; and conducting a management system audit. The factors related to the development, implementation, and adaptation of artificial intelligence within the organization’s management system at each stage of its implementation have been considered. These factors include: rethinking the interaction between people and machines in the work environment; awareness among management and staff; organizational support; openness to innovation; staff resistance to change; the presence of a system for disseminating best practices; availability of critical skills for artificial intelligence implementation; ensuring ethical components such as bias, confidentiality, and transparency; integration of model results into relevant business processes; compatibility with other available information systems; and the satisfaction level of stakeholders with the outcomes of artificial intelligence implementation.
THE EMPIRICAL STUDY OF THE CORRELATION BETWEEN THE DOMINANT STRATEGY OF “INFLEXIBLE HIPPOS” AND THE ORGANIZATIONAL LIFE CYCLE
Authors:   Ukrainian State University of Science and Technologies, Hordieieva Inna , Nezghoda Olga ,   Alfred Nobel University
Published: July 2024

The development of companies is characterised by the adoption of certain stages of business development, the availability of resources and outcomes. This developmental process is inherently cyclical, requiring companies to remain flexible and adaptive continuously. Each phase of the life cycle is characterised by unique challenges, perspectives and inherent features that require strategic modifications to maintain and enhance competitiveness. A holistic interpretation that integrates both life cycle phases and strategic approaches is necessary for a thorough understanding of a company’s success and market performance. The purpose of this paper is to explore the correlation between the dominant strategy employed by industry leaders, known as “inflexible hippos,” and the various stages of the organizational life cycle. The research objects are the dominant strategy “inflexible hippos” and the ten phases of the organizational life cycle: Courtship, Infant, Go-go, Adolescence, Prime, Maturity, Aristocracy, Early bureaucracy, Bureaucracy, and Death. The subject of the research is to verify the existence of a connection and its type between the research objects. The objective of the study is to ascertain the existence and nature of the connection between these research objects. The research methodology employed morphological, analytical, statistical assessment, and comparative analysis techniques. By comparing morphological statements formulated with expert input, evidence was found regarding the existence and significance of the correlation strength. The study revealed that the correlation between competitive strategy and the phases of the company’s life cycle is strongest in the “Maturity” and “Aristocracy” phases, which dictate the sequence of organizational development. The tightest connection with direct independent mutual influence is observed in the “Go-Go”, “Adolescence”, “Prime”, “Reconstruction”, and “Bureaucracy” phases. The context dependence of this correlation characterizes ongoing change processes: the company retains old features of organizational development while simultaneously acquiring new ones. Evaluating the timeliness and efficiency of managerial decision-making based on the alignment of competitive strategy with the company’s life cycle, influenced by both external and internal factors, is a critical stage in the company’s development process. This study can help companies to develop more effective competitive strategies that respond to their current needs. This can lead to improving companies’ competitiveness, selecting appropriate and effective project actions and their success in the market.
DIGITAL ADMINISTRATION IN THE INFORMATION TECHNOLOGY LANDSCAPE – A REVIEW: INSIGHTS FROM MOUNTAIN ECONOMY
Authors: Covaci Mihai ,   Hyperion University & CBM International University, Covaci Brindusa ,   Centre for Mountain Economy & CBM International University
Published: July 2024

The research explores the challenges and advancements in global digital administration, focusing on IoT-driven internet administration. The study proposes hypotheses on digital administration performance and offers insights of IT administration. The scholarly contribution introduces a comprehensive framework with five interconnected indicators for measuring digital administration. These indicators, aligned with hypotheses, assess the socio-economic impact of IT, incorporating complex mathematical formulations. The study utilizes empirical data from reliable sources and employs rigorous statistical analysis, combining qualitative and quantitative approaches to enhance understanding within the IT administration realm. The study examines IT governance in EU, BRICS, and MENA countries through tangible assets. Findings highlight varied resilience levels and advocate for strategic investments, emphasizing the pivotal role of IT in economic development and governance across different intervals. The analysis extends to e-IT governance, digital governance technology, and digital corporate governance technology, demonstrating their impact on socio-economic environments, business performance, and IT development in mountain areas. Within this contextual framework, the authors posit several hypotheses concerning digital administration performance: H1. A robust quality of public and private administration correlates with a strong national economy; additionally, heightened IT administration strength augments general administration – as indicated by the Value Added of IT administration tangible assets from a country (A). H2. Development influences administration in the Research-Development-Innovation (RDI) sector, with the IT part paramount importance – as indicated by the Value Added of IT administration tangible assets from a country (A). H3. Digital administration within an electronic context should foster resilience in the socioeconomic environment of a country – as indicated by the Value Added of e-IT administration from a country (B). H4. Public and private administration, particularly in IT administration, operates under the auspices of technical development – as indicated by the Value Added of digital administration technology from a country (C). H5. IT administration and the overall digital administration environment exert influence on business performance – as indicated by the Value Added of digital corporate administration technology from a country (D), and additionally, the Value Added of digital corporate administration technology in the mountain area (E). Results underscore the interconnectedness of governance quality, development, resilience, and technical advancement in the evolving landscape of digital administration.
SKILLS INDEX AS AN INNOVATIVE APPROACH TO MANAGING SPECIALIST QUALIFICATIONS
Authors:   State University of Trade and Economics, Biliavska Yuliia , Biliavskyi Valentyn ,   National Aviation University, Umantsiv Yurii ,   State University of Trade and Economics, Osetskyi Valerii ,   Taras Shevchenko National University of Kyiv
Published: July 2024

In today’s conditions, we can observe distinctive features of soft and hard skills, which are presented for specialists of different professions. The purpose of the article is to develop an innovative approach to managing specialist qualifications by defining a skills index. Based on this goal, the paper solves the following research tasks of the article: - generalization of research to substantiate the characteristics and components of soft, hard, self and digital skills of a specialist; - substantiation of the conceptual foundations of the specialist skills index to determine the level of knowledge and skills. Professionals across various industries often wonder what essential skills are needed to grow and prosper in business. Debates continue about the choice between collaboration, adaptability, or professionalism with technical skills. The development of personal and professional skills through education, training and meaningful work are key factors in the economic success of the state, individual well-being and social cohesion. The methodological foundation of this study relies on a systematic approach, enabling the examination of a specialist’s skills index. To calculate this index, it’s imperative to construct a questionnaire comprising four skill groups: soft, hard, self, and digital. This will allow us to summarize the results and make calculations. Skills enumerated in the questionnaire are appraised for their importance via expert evaluation method. The list of skills and the weighting criterion should be adjusted for a particular study. The skills index of a specialist will range from a minimum of 0.5 to a maximum of 1. Lower values of this index indicate a lack of necessary skills, and it is also possible to see in which group of skills there are «bottlenecks». After assessing the skills index, specialists, experts, or employees are divided into three conventional sectors: blue, yellow, and pink. The Blue sector includes people who have a wide range of skills (the index is greater than 0.5). Once in this sector, employees receive many benefits, such as bonuses, social packages, gifts, etc. This area continues to be actively developed. The «pink sector» encompasses people with an index value below 0.5, typically representing critical limits due to minimal skill levels. The intermediate sector consists of «promising employees» who constitute potential reserves and are actively engaged in developing their personal talents and abilities. It is undeniable that a well-formed set of soft, hard, self, and digital skills in a professional activity will ensure competitiveness in the labor market not only presently but also in the future.
INFLATION IN POLAND: MACROECONOMIC ANALYSIS
Authors: Oleksy-Gebczyk Aneta ,   University of Applied Sciences in Nowy Sacz
Published: July 2024

The research relevance is predefined by the need to explain the nature of inflation and assess the effectiveness of anti-inflationary policy in Poland. The research aims to study the factors that cause price growth and the tools to reduce its pace during the global economic crisis. The following research methods were used: analysis of statistical data on inflation dynamics; comparison – for comparing price growth indices; expert estimates – for forecasting inflation; graphical – for displaying results; and generalisation – for summarising information on the use of inflation reduction tools. The main results obtained in this study are: determination of the dynamics of producer price indices, consumer prices and the gross domestic product (GDP) deflator in Poland; comparison of Poland’s inflation rate with other European countries and justification of the reasons for its rapid growth; analysis of the use of inflation targeting in Poland, Romania, the Czech Republic and Hungary; and assessment of the effectiveness of the central bank’s increase in the key interest rate and required reserve ratios, as well as the impact of these instruments on the inflation rate in Poland; proving the non-monetary nature of inflation and identifying its main drivers in the period 2020-2023 (coronavirus pandemic, rising global energy and food prices, war in Ukraine); identifying the effects of lowering value-added tax (VAT) rates on certain goods on inflation and tax revenues to the Polish budget; comparing the forecast inflation rate and GDP growth by the end of 2023 and 2024-2025 based on expert estimates; substantiating the ways to slow down inflation, considering a wide range of external factors affecting the Polish economy. The results and conclusions are of practical importance for the Government of the country and managers of the banking sector in developing measures to regulate the rate of price growth.
COMPARATIVE ANALYSIS OF IMMIGRATION POLICY IN EU MEMBERSTATES AND UKRAINE
Authors: Kortukova Tamara ,   State University of Trade and Economics, Tokar Volodymyr ,   State University of Trade and Economics
Published: July 2024

This article presents an in-depth comparative analysis of the migration policies of the European Union and Ukraine. The study aims to identify and examine the similarities and differences between these two migration systems, considering their underlying objectives, legal frameworks, and approaches to managing migration flows. By analyzing various aspects of migration policies, including labor migration, combating of illegal migration, as well as international protection systems, such as asylum, subsidiary and temporary protection, the article aims to provide a comprehensive understanding of the different strategies employed by the EU and Ukraine in managing migration. The analysis begins by discussing the drivers of migration in both EU and Ukraine, highlighting the diverse dynamics and complexities that have shaped their migration policies. It explores the EU’s migration policy framework, encompassing the common asylum system. Similarly, it delves into Ukraine’s migration policy framework, emphasizing its legal framework and analizing policies towards beneficiaries of temporary protection and cooperation with EU in this sphere. Through a comparative lens, the article evaluates various dimensions of migration policies in the EU and Ukraine. Firstly, it examines the policy objectives in EU and Ukraine, assessing how they align with broader socio-economic, security, and demographic considerations. Secondly, the article examines the legislative framework and analyzes the legislative instruments that regulate migration in both the EU and Ukraine. It also emphasizes the compatibility of supranational EU legislation with the legal system of Ukraine, which is extremely important given Ukraine’s status as a candidate for accession to the EU. Finally, the article identifies areas of convergence and divergence between the migration policies of the EU and Ukraine and reflects on their implications for both regions. It recognizes the challenges and limitations faced by each system. The analysis aims to provide insights for policymakers in the EU and Ukraine to enhance their migration management strategies and foster greater collaboration in addressing the complexities of migration. Overall, this comparative analysis of EU and Ukrainian migration policies contributes to a comprehensive understanding of the various dimensions of migration management, offering a foundation for further research, policy development, and collaboration between the EU and Ukraine.
MODIFICATION OF ISM TO RISM (RATIONAL INTERPRETIVE STRUCTURAL MODELLING) IN THE CONTEXT OF EMPLOYEE RETENTION THROUGH CRM AND PERFORMANCE
Authors: Sahoo Tushar Ranjan ,   NIST (Autonomous), Odisha, Zadoia Anatolii O. , Sahoo Sandhyarani , Sahoo Saroj Kumar ,   Alfred Nobel University,   Sambalpur, Odisha,   Sambalpur University, Burla, Odisha
Published: July 2024

The paper explores the potential of CRM as a strategic element (along with performance, customer and bank perspectives, and demographic changes) for employee retention (using the Indian banking system as an example). The banking industry was chosen for this study because it is a service sector where transactions involving sensitive products (financial instruments) attract maximum attention from both employees and customers in the long run. To achieve this goal, the authors identified the main factors of customer relationship management that make it effective. The study investigated the relationship between CRM practices, the efficiency of banking operations, and the retention of bank employees. The analysis showed that bank employees have a much greater potential to influence the effectiveness of its activities than clients. Therefore, banks’ management should pay more attention to the recruitment of personnel, not only to the CRM system. The article specifically investigated the rationality of the relationship between CRM, bank branch efficiency, employee retention, and demographic variables. This allowed for several options for banks’ strategies in forming a stable staff of employees to be proposed. An important result of the study was the justification of the modification and addition of the ISM (Interpretive Structural Modelling) mechanism, which received a new name - RISM (Rational Interpretive Structural Modelling). Without violating the basic rules of ISM, the new mechanism allows to achieve better results, as it enables the development of a strategy for independent variables with a more accurate prediction of results.
INTEGRAL ASSESSMENT OF THE FINANCIAL STABILITY OF UNIVERSITIES
Authors: Yurchyshena Liudmyla ,   Vasyl’ Stus Donetsk National University
Published: July 2024

University management systematically faces the problem of objectively assessing the financial stability of higher education institutions (HEIs). This challenge arises due to the influence of external drivers, including the instability of institutional support, changes in approaches, reductions in budget funding, the consequences of the Covid-19 crisis, war, population migration abroad, destruction of the material and technical base of HEIs, a decrease in the solvency of the population, and the psychological status of employees. In the paradigm of this study, the financial stability of universities is investigated as their ability to form a positive financial space, create value propositions considering time demands, ensure income growth and diversification, rational distribution of resources, maintain liquidity and solvency, and respond flexibly and quickly to the challenges of the time. The purpose of the article is to methodologically justify and practically implement the integral assessment of the financial stability of universities based on the point method, utilizing both static and dynamic approaches. The information base of this study comprises data from the Unified State Electronic Database on Education as of October 1 of the reporting year, financial information, and rectors’ reports for the years 2017 to 2022, which were published on the websites of the Higher Education Institutions. The sample includes 35 HEIs of Ukraine, varying in types (classical, polytechnic, pedagogical, economic, and others), scale, and location. The main results of the study are as follows: - a three-criterion approach to determining the integral indicator of financial stability: the first criterion is contingent (scale), encompassing indicators demonstrating changes in student numbers according to public and private forms of education, the ratio of teacher supply to applicants, the level of budget allocations and private financing per student, and expenses for wages per student; the second criterion is cash flows, represented by liquidity indicators and a financial cushion; the third criterion is income and expenses, including indicators characterizing the change in income, their diversification, the level of income per 1 student and teacher, the share of marginal income, the ratio of income and expenses, the coefficient of coverage of fixed expenses by income; -the method of calculating the integral indicator of financial stability based on static and dynamic approaches was justified and tested using the example of 35 HEIs in Ukraine; - four types of financial stability of universities were established according to the maximum value of the integral indicator: stable (41–50 points), normal (31–40 points), risky (21–30 points), and crisis (20 or fewer points). The method of calculating the integral indicator of financial stability of universities proposed in the article is a tool for making tactical and strategic decisions by university management.
EXECUTION AND FINANCING OF LOCAL BUDGETS IN UKRAINE: FEAUTURES AND RESULTS
Authors: Yushko Serhii ,   Kharkiv National University of economics named after Simon Kuznets
Published: July 2024

The article examines the absolute and relative indicators of local budget execution for the period 2013-2022. It emphasizes the importance of analyzing the results of local budget implementation at the level of individual local estimates within their respective groups according to the structure of the budget system. It was demonstrated that the overall results of local budget execution, when viewed as a whole system, conceal significant differentiation among the indicators of individual budgets. It was found that the deficit of the vast majority of local budgets in Ukraine is allowed to be covered exclusively by using internal sources of funds. Under these circumstances, a situation of forced balancing of budgets in the presence of a number of unresolved issues in the relevant council is likely, which, of course, distorts the perception of the real state of local budgets. It was also found that the most common way of financing local budgets in Ukraine is through changes in budget balances. Placement of funds on deposits is also popular, which, among other things, provides local budgets with additional income. Financing through transactions with securities has not become widespread. According to the results of the analysis of the features of financing local budgets through debt operations, options for balancing deficit budgets, applied by the relevant councils in practice, were identified and named. The need to improve the efficiency of management of the resources borrowed by the councils, as well as the available balances of budget funds, was emphasized. Recommendations were given for evaluating the results of the implementation of local budgets, based not only on the absolute values of the budget deficit (surplus), but also taking into account the components and financing structure of the relevant estimates. The expediency of paying closer attention to indicators of the deficit of budgets financed by debt operations, in particular in the part of substantiating the borrowings and their results, as well as the borrower’s compliance with the limits of borrowings and costs for their servicing established by the budget legislation, is emphasized. It was stressed that a qualitative assessment of the results of budget execution is impossible without involving in the analysis of other indicators, including, in particular, the amount of overpaid taxes and fees to the budget, the payables of budget institutions, the amounts of taxes accrued by their payers, but not paid to the budget. Equally important are the clarification of the dynamics of socio-economic development indicators of the relevant community (territory), the state of the budget sphere: in the presence of unresolved issues, the balanced budget that is adopted cannot be considered as reflecting the real state of local finances.
RECOGNITION AND ACCOUNTING OF GOVERNMENT GRANTS IN NONPROFIT ORGANIZATIONS: NATIONAL AND INTERNATIONAL APPROACHES (IFRS)
Authors: Osipchuk Daryna S. ,   Zhytomyr Polytechnic State University, Chyzhevska Lyudmyla V. , Khomenko Hanna Yu. ,   Zhytomyr Polytechnic State University,   Zhytomyr Polytechnic State University
Published: July 2024

This article explores the issues related to the accounting treatment of government grants by nonprofit organizations. The study identifies key problematic aspects in recognizing revenue from government grants by non-profit organizations. The authors investigate the challenges associated with the accounting of operations involving government grants and earmarked receipts in the practices of non-profit organizations in Ukraine. Additionally, the article highlights the peculiarities of accounting for passive incomes in the records of non-profit organizations. Furthermore, the research presents a comparative analysis of the national accounting practices for grants and passive incomes in Ukraine and several foreign countries. The examination of accounting and tax legislation in foreign countries forms the basis for developing a methodology for reflecting the operations related to revenues of nonprofit organizations, considering both earmarked receipts and incomes arising from economic activities or passive sources. The research results provide recommendations regarding the accounting treatment and recognition of revenues from grants, earmarked receipts, and passive incomes. The study argues against the applicability of treating passive incomes as earmarked financing and proposes two models for recognizing such incomes based on the tax regulation of non-profit organizations in the country. Specifically, a distinction is made between models for non-profit organizations that are subject to income tax and those that are exempt from it. The authors propose an accounting ledger model for recording transactions related to receipts from the government and other private sources. Additionally, the study offers recommendations for adapting the provisions of IAS 20 «Accounting for Government Grants and Disclosure of Government Assistance» for the accounting of government grants and earmarked receipts by non-profit organizations. The research results illuminate two models for recognizing revenues from asset-related grants, taking into account the specific utilization of such assets in the activities of non-profit organizations.
Congratulations to Academician Ivan Aleksandrovich Novakov on his 75th birthday!
Authors: Editorial Article
Published: July 2024

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Concentration of heavy metal ions from aqueous media under dynamic conditions using a composite sorbent based on chitosan and silica
Authors: Gabrin V. A. , Nikiforova T. E. , Kozlov V. A. , Razgovorov P. B.
Published: July 2024

Objectives. The study set out to investigate the sorption, toxicological, and regeneration properties of a composite sorbent based on chitosan hydrogel and unsuspended silicon dioxide (chitosan–colloidal silica), which manifest themselves under dynamic conditions of purification of aqueous solutions, as a means of removing heavy metal ions.Methods. The total dynamic exchange capacity of a chitosan–colloidal silica composite sorbent was evaluated under dynamic sorption conditions by passing solutions containing Zn(II), Cd(II), Cu(II), and Cr(III) ions having a concentration of 240–251 mg/L through a fixed sorption bed. The method for determining acute toxicity using daphnia (Daphnia magna Straus) is based on the direct calculation of the mortality of daphnia exposed to toxic substances contained in the test aqueous extract in comparison with a reference culture in samples that do not contain toxic substances. The regeneration ability of the sorbent was assessed by counting the number of sorption–desorption cycles using 0.1 M NaOH and 0.1 M NaHCO3 eluents, as well as aqueous solutions of H2O2 (1 and 3%).Results. The effectiveness of the chitosan–colloidal silica composite sorbent in the process of dynamic purification of aqueous media to remove Cu(II), Zn(II), Cd(II), and Cr(III) ions was established. After determining the times of ion breakthrough and saturation of the developed sorbent, its dynamic exchange capacity was calculated by processing the kinetic curves of sorption of heavy metal ions under dynamic conditions. The results of regeneration of the sorbent were presented in the context of the possibility of its reuse. It is shown that the sorbent can withstand up to five sorption–desorption cycles while maintaining a level copper cation extraction above 90%.Conclusions. Analysis of the kinetic curves demonstrated that the driving force behind the removal of heavy metals from aqueous media by means of the obtained sorbent is the external diffusion mass transfer of ions from the mobile phase of the solution. Biotesting of samples showed that the developed chitosan-based sorbent does not have acute toxicity.
L-Ornithine derivatives with structural hetaryl and alkyl moiety: Synthesis and antibacterial activity
Authors: Bodrova T. G. , Budanova U. A. , Sebyakin Yu. L.
Published: July 2024

Objectives. Cationic amphiphiles and antimicrobial peptidomimetics are widely investigated as antibacterial agents due to their membrane-active mechanism of action. Particular attention is focused on the rational design of compounds in this class to achieve high antimicrobial activity. The aim of the present work is to synthesize bivalent cationic amphiphiles with L-ornithine as a branching element and evaluate the effectiveness of their antibacterial action. The compounds differ in terms of hydrophobicity due to the variation of N-terminal aliphatic amino acids in the polar block and alternation of dialkyl and alkyl-hetaryl radicals in the lipophilic block.Methods. For the synthesis of nonpolar fragments of amphiphiles, methods for the alkylation of amines with alkyl bromides in the presence of carbonate salts were used. The formation of amide bonds of L-ornithine derivatives with amino acids was carried out using the carbodiimide method. For the reaction products recovery from the reaction mixture, column chromatography on silica gel and aluminum oxide activated Brockmann Grade II was used. The antimicrobial activity of the synthesized compounds against gram-positive B. subtilis 534 and gram-negative E. coli M17 bacterial strains was evaluated. Minimum inhibitory concentration (MIC) values were recorded using a serial microdilution method in a nutrient medium.Results. Developed schemes for the preparation of bivalent cationic amphiphiles based on L-ornithine derivatives are presented. Differences in the structure of aliphatic amino acids (glycine, β-alanine, γ-aminobutyric acid (GABA)), in the length of alkyl radicals (C8, C12), or in the presence of an indole moiety, were used in the design of target compounds. The high antibacterial activity of the synthesized compounds was demonstrated. The most active compounds were lipoamino acids with terminal GABA residues and asymmetrical non-polar block (tryptamyl–dodecylamine). The MIC values were 0.39 μg/mL for gram-positive bacteria and 1.56 μg/mL for gram-negative bacteria. A GABA derivative with a symmetrical lipophilic moiety based on dioctylamine demonstrated activity with an MIC of 0.78 μg/mL against B. subtilis and 3.12 μg/mL against E. coli.Conclusions. Nine new lipoamino acid cationic bivalent amphiphiles based on L-ornithine were synthesized. The structure of the obtained compounds was confirmed by nuclear magnetic resonance 1H spectroscopy and mass spectrometry data. Leading compounds in antimicrobial activity against both gram-positive and gram-negative strains of bacteria were determined. The influence of the degree of lipophilicity in the asymmetric nonpolar block on the level of exhibited antimicrobial activity is demonstrated.
Methylation of a group of microRNA genes as a marker for the diagnosis and prognosis of non-small cell lung cancer
Authors: Loginov V. I. , Gubenko M. S. , Burdennyy A. M. , Pronina I. V. , Postnikov P. V. , Efimova Yu. A. , Radus F. V. , Mochalova E. S. , Kazubskaya T. P.
Published: July 2024

Objectives. Lung cancer, representing a difficult-to-diagnose heterogeneous malignant neoplasm, is characterized by an asymptomatic course up to late stages, a high incidence of adverse outcomes, and a high probability of metastasis. Its most common form is non-small cell lung cancer (NSCLC). Recent studies have demonstrated a significant role of non-coding RNAs—in particular, microRNAs—in the development of NSCLC. MicroRNAs, which function as post-transcriptional regulators of the expression of protein-coding genes, including those associated with oncogenesis, are involved in the processes of cell proliferation, differentiation, and apoptosis. One of the approaches for regulating the expression of microRNAs themselves is to change the methylation of the CpG island adjacent to the microRNA gene or overlapping it. It has been shown that microRNA genes are several times more likely to undergo methylation than protein-coding genes. The aim of the present work is to study changes in the level of methylation of a number of microRNA genes and compile a potential panel of markers for the diagnosis and prognosis of NSCLC.Methods. Samples of NSCLC tumors were collected and clinically characterized at the Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia. High-molecular-weight DNA was isolated from tissues using a standard method. The level of methylation was analyzed using bisulfite conversion of DNA and quantitative methyl-specific polymerase chain reaction with real-time detection. The significance of differences between the studied groups was assessed by the nonparametric Mann–Whitney U test for independent samples. Differences were considered significant at p < 0.05.Results. The analysis of methylation levels of microRNA genes revealed a significant (p < 0.05) increase in the methylation level of eight microRNA genes: MIR124-1/2/3, MIR125В-1, MIR129-2, MIR137, MIR375, MIR1258, and MIR339 (p < 0.01, false discovery rate ≤ 0.25). On the basis of receiver operating characteristic analysis, a panel of markers is proposed for the diagnosis of NSCLC according to the nature of methylation of the studied microRNA genes in the tumor and in the normal tissue.Conclusions. Our results, which contribute to the understanding of molecular mechanisms involved in NSCLC development, can be used in the development of new diagnostic and prognostic approaches in clinical oncology.
Development of technology for culturing a cell line producing a single-domain antibody fused with the Fc fragment of human IgG1
Authors: Polyansky D. S. , Ryabova E. I. , Derkaev A. A. , Starkov N. S. , Kashapova I. S. , Shcheblyakov D. V. , Karpov A. P. , Esmagambetov I. B.
Published: July 2024

Objectives. To develop an effective technology for the cultivation of Chinese hamster ovary (CHO) cells stably producing GamP2C5 antibody which is a component I of the GamCoviMab candidate drug for emergency prevention and therapy of  infection caused by SARS-CoV-2 virus; to select optimal cultivation parameters and to scale this technology in production.Methods. The study was performed on CHO GamP2C5 (clone 78) cell culture, producing a single-domain antibody fused to the Fc fragment of human IgG1 GamP2C5. Different culture media and supplements were used. Cells were cultured in Erlenmeyer flasks, Biostat® RM 20 wave-mixed bioreactor, Ambr® 250 mini bioreactors, STR 200 stirred-tank bioreactor.Results. Using molecular-genetic and biotechnological methods, a stable clone producer of CHO GamP2C5 antibody, clone 78, was obtained. Then a technique was worked out for the cultivation of the obtained clone producer on different culture media. The most suitable cultivation regimes, culture media, and optimal supplements were selected. This technology was tested in laboratory conditions in a 10-L reactor, and then successfully scaled up for production at the MedGamal Branch of the Gamaleya National Research Center for Epidemiology and Microbiology.Conclusions. This study demonstrates the fundamental feasibility of developing and scaling up a culture technology, in order to produce a drug based on a modified single-domain antibody with virus neutralizing activity against different strains of SARS-CoV-2 virus.
Solid solutions in disulfide systems Re(IV)S2–Ti(IV)S2, Re(IV)S2–Mo(IV)S2, and Re(IV)S2–W(IV)S2
Authors: Efremova E. I. , Lazov M. A. , Kobrin M. R. , Fomichev V. V.
Published: July 2024

Objectives. Chalcogenides of transition elements with low oxidation states, as well as their substituted derivatives, remain a poorly studied class of chemical compounds. Rhenium disulfide has many distinctive features and great application potential as a new twodimensional semiconductor. This is due to its unusual structure and unique anisotropic properties. The presence of weak interlayer bonding and a unique distorted octahedral (1T) structure suggests the possibility of creating new phases on its basis. The aim of this work is to obtain and study phases in systems Re(IV)S2–Ti(IV)S2, Re(IV)S2–Mo(IV)S2, and Re(IV)S2–W(IV)S2.Methods. The samples were obtained by high-temperature solid-phase ampoule synthesis in a vacuum. The study was carried out using X-ray phase analysis and X-ray photoelectron spectroscopy.Results. The regions of existence of solid solutions, intercalates and two-phase regions in the resulting systems were established.Diffraction patterns were obtained for the new phases and the crystal lattice parameters were calculated. Based on data relating to the binding energies of core electrons with the nucleus, the study showed the valence states of the elements after synthesis. The study also confirmed that all phases obtained as a result of synthesis contain transition elements in the oxidation state (IV).Conclusions. Intercalated solid solutions are formed in areas rich in rhenium, while in areas close to titanium and molybdenum disulfides, intercalated phases are attained. In the ReS2–WS2 system there is a region of solid solutions, including 30, 50, and 70 mol % rhenium disulfide. Their structure is a polymorphic modification of the structure of the original components. The presence of rhenium, molybdenum, and tungsten in these phases in the oxidation state (+IV) was confirmed. The data obtained on phase formation in dichalcogenide systems can be practically used in the creation of materials with unique electronic, magnetic, and optical properties with a wide range of applications.
Pengetahuan Ibu Hamil melalui edukasi menggunakan aplikasi E-Modul tentang pemenuhan kesejahteraan ibu dalam upaya mencegah stunting di Puskesmas Mangasa Makassar
Authors: Afriani Afriani , Sabur Fitriati , Amin Wirawati
Published: July 2024

Stunting dapat juga terjadi sebelum kelahiran dan disebabkan oleh asupan gizi yang sangat kurang saat masa kehamilan, pola asuh makan yang sangat kurang, rendahnya kualitas makanan sejalan dengan frekuensi infeksi sehingga dapat menghambat pertumbuhan. Salah satu upaya untuk mencegah anak lahir stunting dibutuhkan peran banyak pihak, termasuk peran SDM Penyelenggara Kesejahteran Sosial, yang berperan sebagai edukator, motivator, mobilisator. Termasuk peran keluarga dan masyarakat untuk dapat menyejahterakan ibu hamil dengan cara memenuhi kebutuhan dasarnya. Tujuan umum dalam penelitian ini adalah diketahuinya upaya pencegahan stunting pada ibu hamil melalui edukasi menggunakan aplikasi E-modul tentang pemenuhan kesejahteraan ibu di Puskesmas Mangasa Makassar. Penelitian ini menggunakan rancangan Pre eksperimental dengan one group  pretest – posttest Jumlah Populasi dalam penelitian ini sebanyak 55 orang ibu hamil di Puskesmas Mangasa Makassar. Proses pengumpulan data dengan kuesioner dengan menggunakan google form dalam bentuk quizizz. Data tersebut kemudian dianalisis untuk mengetahui pengetahuan ibu hamil dengan menggunakan melalui  E-modul tentang pemenuhan kesejahteraan ibu dengan menggunakan Uji T Paired test. Hasil penelitian menunjukkan adanya peningkatan pengetahuan ibu hamil melalui edukasi penggunaan aplikasi E-modul dan quizizz melalui google form tentang pemenuhan kesejahteraan ibu di Puskesmas Mangasa Makassar dengan nilai p=0,000. Diharapkan pendampingan bidan dan keluarga terkait pemenuhan kesejahteraan ibu selama hamil dalam upaya mencegah stunting
Identifikasi Jamur Pada Terigu Yang Dijual Tanpa Merek di Pasar Besar Kota Palangka Raya
Authors: Banjarani Alifia , Immanuela Toemon Agnes , Sri Martani Natalia , Jabal Arif Rahman , Mutiasari Dian
Published: July 2024

Makanan yang baik adalah makanan yang tidak mengandung bahan berbahaya dan memenuhi standar higiene dan sanitasi, akan tetapi BPOM menyatakan bahwa ditemukan gedung distributor dan sarana ritel yang menyimpan bahan makanan yang rusak, kadaluwarsa, dan ilegal, salah satunya adalah tepung terigu yang rusak akibat kontaminasi jamur yang berasal dari bulir/biji gandum. Tepung terigu yang berisiko tinggi terkontaminasi jamur dengan baik adalah tepung terigu yang dijual tanpa merek dan menggunakan plastik tipis transparan sehingga memudahkan masuknya udara yang terdapat spora jamur. Mengetahui keberadaan jamur serta mengidentifikasi spesies jamur yang ditemukan pada tepung terigu yang dijual tanpa merek di Pasar Besar Kota Palangka Raya. Jenis penelitian ini menggunakan metode deskriptif dengan desain cross sectional. Populasi penelitian berjumlah 41 tepung terigu yang dijual tanpa merek di Pasar Besar Kota Palangka Raya, dengan teknik sampling menggunakan purposive sampling berdasarkan kriteria inklusi dan eksklusi. Instrumen penelitian yang digunakan adalah mikroskop. Teknik pengolahan data meliputi coding, tabulating, entering, editing, dan cleaning dengan teknik analisis secara univariat (analisis deskriptif) dan menggunakan rumus persentase. Hasil pemeriksaan 41 sampel tepung terigu dan identifikasi jamur dengan menggunakan media SDA (Sabouraud Dextrose Agar) didapatkan persentase sebanyak 100% positif terkontaminasi jamur Aspergillus spp. Hasil yang diperoleh dari penelitian ini adalah didapatkan keseluruhan (100%) sampel tepung terigu positif terkontaminasi jamur Aspergillus spp.
Hubungan Rinitis Alergi Dengan Kejadian Sinusitis Di Rsud Dr Doris Sylvanus
Authors: Toemon Angeline Novia , Hasan Muhamad Umar Muhtar , Jabal Arif Rahman , Teresa Astrid , Praja Rian Ka
Published: July 2024

Sinusitis merupakan inflamasi mukosa sinus paranasal menjadi salah satu gangguan kesehatan dunia dan sering ditemukan pada praktik kedokteran. Survei The National Health Interview tahun 2012, ditemukan sebanyak 12% dari total sampel 34.525 orang dewasa mengalami sinusitis. Rinitis alergi merupakan salah satu faktor penyebab sinusitis karena infeksi bakteri pada saluran sinus akibat penyumbatan ostium sinus dan mukus yang tidak dapat dialirkan disebabkan reaksi alergi. Penelitian ini bertujuan menganalisis hubungan rinitis alergi dengan kejadian sinusitis pada pasien di RSUD dr Doris Sylvanus Palangka Raya. Penelitian ini merupakan penelitian observasional analitik  dengan  desain  studi cross section yang dilakukan di RSUD dr Doris Sylvanus Palangka Raya. Subjek dalam penelitian ini adalah pasien riwayat rinitis alergi dan sinusitis periode tahun 2021-2023 yang memenuh kriteria inklusi dan eksklusi. Terdapat 271 sampel penelitian dimana pada uji statistik menunjukan nilai p = 0,000 dan OR = 0,092. Rinitis alergi memiliki hubungan dengan sinusitis dan rinitis alergi berpeluang mengalami sinusitis.
Tinjauan Hubungan Antara Kebiasaan Sarapan, Kebiasaan Jajan Dan Asupan Zat Gizi Dengan Kekurangan Energi Kronis Pada Siswi SMAN 18 Makassar
Authors: Sari Novi , Khatimah Husnul
Published: July 2024

Pada usia remaja sering terjadi masalah Kesehatan berkaitan dengan asupan zat gizi, cenderung mengalami kekurangan gizi (kalori dan protein), kebiasaan melewatkan sarapan dan kebiasaan jajan yang kurang sehat yang dapat mengakibatkan terjadinya kekurangan energi kronis (KEK). Tujuan penelitian ini adalah untuk mengetahui hubungan kebiasaan sarapan, kebiasaan jajan dan asupan zat gizi dengan kejadian kekurangan energi kronis pada siswi SMAN 18 Makassar. Desain penelitian  yang  digunakan  adalah cross  sectional.  Populasi dalam penelitian ini adalah seluruh remaja putri kelas XI dan XII di SMA Negeri 18 Makassar sebanyak 504 orang.   Sebanyak  54 siswi dipilih  menjadi  sampel  secara simple random sampling. Data  yang  dikumpulkan meliputi  kebiasaan  sarapan dan kebiasaan jajan  dengan  wawancara  langsung  menggunakan  kuisioner,  asupan zat  gizi diperoleh  dengan  metode food  recall 24  jam,  dan status  gizi  ditentukan  berdasarkan  pengukuran Lingkar Lengan Atas (LiLA). Hasil penelitian menunjukkan bahwa ditemukan sebanyak 59.2% siswi yang mempunyai kebiasaan sarapan sering dan 79.6% siswi yang mempunyai kebiasaan jajan sering. Terdapat 88.9% siswi dengan kategori asupan energi kurang dan 77.8% siswi dengan kategori asupan protein kurang. Serta ditemukan sebanyak 59.3% siswi yang mengalami KEK. Tidak ada hubungan kebiasaan sarapan, kebiasaan jajan, asupan energi dan protein dengan Kekurangan Energi Kronis pada Siswi di SMAN 18 Makassar (p value >0.05). Namun Proporsi siswi yang asupan energi dan protein kategori kurang lebih banyak yang mengalami KEK. Kesimpulan dalam penelitian ini adalah tidak ditemukan hubungan antara kebiasaan sarapan, kebiasaan jajan, dan asupan zat gizi dengan kejadian kekurangan energi kronis.
Hubungan Perilaku Makan Dengan Kejadian Kurang Energi Kronik (KEK) Pada Remaja Putri
Authors: Sukmawati Sukmawati , Mustamin Mustamin , Adam Adriyani , Ningsih Ana Purnama
Published: July 2024

Kurang Energi Kronik menjadi salah satu masalah gizi utama yang banyak dialami oleh kalangan remaja, terutama pada remaja putri. Berdasarkan hasil data Riskesdas (2018) prevalensi KEK pada remaja putri di Indonesia sebesar 36,3%. Remaja yang mengalami KEK berisiko melahirkan bayi prematur, perdarahan saat persalinan, kematian bayi dan anak serta melahirkan bayi <2,5 kg yang sering disebut Berat Bayi Lahir Rendah (BBLR). Tujuan penelitian adalah mengetahui hubungan perilaku makan dengan kejadian kurang energi kronik pada remaja putri. Jenis penelitian yang digunakan adalah penelitian analitik dengan pendekatan cross–sectional study. Penelitian dilaksanakan pada bulan Juni s/d Agustus 2023. Sampel dalam penelitian ini adalah  siswi kelas XI di SMA Negeri 21 Makassar yang terpilih sebagai sampel dengan jumlah 75 orang. Pengambilan sampel dengan metode Accidental Sampling.
Variabel dalam penelitian ini adalah tingkat pengetahuan, sikap dan tindakan tentang gizi seimbang yang diperoleh menggunakan kuesioner. Analisis statistik yang digunakan adalah uji chi square. Hasil uji statistik hubungan tingkat pengetahuan dan tindakan dengan KEK keduanya menunjukkan nilai p=0,00(p<0,05) artinya terdapat hubungan yang signifikan antara pengetahuan dan tindakan dengan kejadian KEK. Hubungan sikap dengan KEK menunjukkan nilai p=0,07(p>0,05) artinya tidak terdapat hubungan yang signifikan antara sikap dengan kejadian KEK. Disimpulkan bahwa remaja putri dalam penelitian ini memiliki pengetahuan dan tindakan yang baik terhadap gizi seimbang, meskipun sikap mereka dominan negatif. Diharapkan kepada remaja untuk lebih meningkatkan pengetahuan gizi yang nantinya dapat merubah sikap menjadi positip tentang gizi seimbang melalui persuasi serta tekanan dari orang sekitarnya sehingga sadar akan pentingnya kesehatan dengan memenuhi kebutuhan zat gizi dengan prinsip gizi seimbang.
Kata kunci : KEK, Pengetahuan, Sikap, Tindakan