bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Technologies for the Discovery of Novel Diversity in Cyanobacteria and Algae and the Elucidation of Their Valuable Metabolites
Authors: Zammit Gabrielle , Zammit Maria G. , Buttigieg Kyle G.
Published: November 2023

Until recently, the study of cyanobacteria and microalgae has been hampered by the need to cultivate these organisms to gain insight into their cytomorphology, life cycle and molecular biology. However, various microbial species characterized by thick sheaths of exopolymeric substances were difficult to isolate in culture due to their associated symbiotic bacteria. Other microbes evaded culture. Such challenges have now been overcome by the development of metagenomic techniques that allow direct DNA sequencing from environmental samples, as well as high resolution microscopy techniques that permit direct imaging of environmental samples. The sampling of understudied taxa from extreme environments and of toxic species has been facilitated by specialized robotic equipment. Single-cell sequencing has allowed for the proper characterization of microalgal species and their response to environmental changes. Various strains of cyanobacteria, microalgae and macroalgae have gained renewed interest for their high-value metabolites. This paper provides an overview of the emerging technologies and explains how they are being used to identify such strains and their products for industrial application. Advances in genetic engineering and CRISPR technology have facilitated the production of strains that are more amenable to culture, metabolite extraction, scale-up and application in biorefinery approaches. Emerging analytical techniques are discussed, with the advent of multiomics and its application in this field.
A Model for Material Metrics in Thermoelectric Thomson Coolers
Authors: Zebarjadi Mona , Akbari Omid
Published: November 2023

Thomson heat absorption corresponding to changes in the Seebeck coefficient with respect to temperature enables the design of thermoelectric coolers wherein Thomson cooling is the dominant term, i.e., the Thomson coolers. Thomson coolers extend the working range of Peltier coolers to larger temperature differences and higher electrical currents. The Thomson coefficient is small in most materials. Recently, large Thomson coefficient values have been measured attributed to thermally induced phase change during magnetic and structural phase transitions. The large Thomson coefficient observed can result in the design of highly efficient Thomson coolers. This work analyzes the performance of Thomson coolers analytically and sets the metrics for evaluating the performance of materials as their constituent components. The maximum heat flux when the Thomson coefficient is constant is obtained and the performance is compared to Peltier coolers. Three dimensionless parameters are introduced which determine the performance of the Thomson coolers and can be used to analyze the coefficient of performance, the maximum heat flux, and the maximum temperature difference of a Thomson cooler.
Agro-Pastoral Expansion and Land Use/Land Cover Change Dynamics in Mato Grosso, Brazil
Authors: Yoshikawa Sayaka
Published: November 2023

Large-scale land use/land cover changes have occurred in Mato Grosso State (hereafter MT), Brazil, following the introduction of extensive mechanized agriculture and pastoral activities since the 1980s. Author investigated what kind of agro-pastoral activities which are both cattle ranching and top five crops (soybean, sugarcane, corn, cotton and rice) that are closely related to land use change on lands experiencing conversion land use change (such as deforestation and the increase in deeply anthropogenically influenced areas) at each municipal district in MT. Then, this study identifies the volume of exports including contribution ratio by municipal districts where land use changed due to agro-pastoral activities. The patterns of vegetation change indicated that cattle ranching, corn, cotton, rice croplands in the northwest, and soybean and sugarcane fields in the central areas are the main contributors to deforestation. It is shown that land use change due to soybean or corn cultivation occurs mainly in the west and the southeast, respectively. Corn cultivation is associated with a greater increase in anthropogenically influenced areas than soybean cultivation. The municipal districts that export each agro-pastoral product with land use change are limited. Exports of soybeans, corn, and cotton in the municipal districts associated with deforestation had increased dramatically after experienced land use change. For example, Sapezal, which has experienced deforestation, was the only municipal district associated with export of corn to only Switzerland. Since 2007, the number of export partners has increased to 56 countries with the export volume increased 2300 times. These findings highlight the overall non-sustainability of environmental resource development activities in MT.
A Model of Integration between a CSP System and a PV Solar Field Sharing a Solid Particles Two-Tanks Thermal Storage
Authors: D’Auria Marco , Grena Roberto , Caputo Giampaolo , Balog Irena , Ferruzzi Gabriella , Bassetti Fulvio , Bevilacqua Carla , Cilento Mario , Magaldi Raffaello , Lanchi Michela
Published: November 2023

The integration of a CSP tower system with a PV solar field, sharing a thermal energy storage, is modeled and discussed. The tower system uses a new-design solid particle fluidized bed receiver integrated with a thermal storage, where hot particles are directly collected to store daily energy for overnight production of electricity. The PV solar field is aimed to supply the daily energy demand; when there is a surplus of PV energy production, the electric energy is converted to heat and accumulated in the thermal storage too. The integration of the two energy systems is modeled, building efficiency functions for all the sub-components of the integrated plant (heliostat field, receiver, storage, power block, PV field). Yearly simulations are performed for two different locations, Spain and Australia, obtaining that a system with a peak power of 10 MWe CSP + 15 MWe PV can supply—with a limited curtailment—a fraction of more than 60% (respectively, 62% and 68%) of a realistic electric load with a peak demand around 10 MW, to be compared with the 45/47% of the same load obtained adopting a PV-only system with the same overall peak power. In the integrated system, PV directly supplies 40/41% of the load, the remaining 23/28% being produced by the power block (mainly fed by the CSP).
Pore-Scale Analysis of the Permeability Damage and Recovery during Cyclic Freshwater and Brine Injection in Porous Media Containing Non-Swelling Clays
Authors: Bhuvankar Pramod , Cihan Abdullah , Birkholzer Jen T.
Published: November 2023

Permeability damage in subsurface porous media caused by clay mobilization is encountered in many engineering applications, such as geothermal energy, water disposal, oil recovery, and underground CO2 storage. During the freshwater injection into rocks containing brine, the sudden decrease in salinity causes native clay fines to detach and clog pore throats, leading to a significant decline in permeability. The clay fines detach due to weakened net-attractive forces binding them to each other and the grain. Past experiments link this permeability damage on the immediate history of the salinity and the direction of flow. To better understand this phenomenon, we conducted pore-scale simulations of cyclic injection of freshwater and brine into sandstone containing Kaolinite clay. Our simulations establish a link between the clay-fine trajectory and the permeability trend observed by Khilar and Fogler (1983). For a uniform clay size of 3 microns, we observe a permeability decline by two orders of magnitude during freshwater injection with respect to brine injection. Increasing salinity and simultaneously reversing flow direction restores the permeability. The permeability restoration upon reversing the brine flow direction is attributed to the unblocking of pore throats in the reverse direction by the movement of the clay particles along the grain surfaces by the hydrodynamic force and the strong net-attractive force under high salinity.
A Systematic Review on the Application of Ultraviolet Germicidal Irradiation to HVAC Systems
Authors: Cattai Francesca , D’Orazio Annunziata , Sbardella Gianluca
Published: November 2023

With the renewed focus on indoor air quality (IAQ) due to “Sick building syndrome” and the recent COVID-19 pandemic, the availability of innovative components and innovative guidance for maintenance and systemic safety design will play an important role, with HVAC systems as protagonists. UV-C irradiation has been investigated for a long time, and some system solutions are known. The aim of this work is to provide an overview of the latest outcomes related to the innovative components of HVAC systems using UV-C irradiation and investigate the current state of the art. A procedure based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was adopted, and the Scopus database was used to query the relevant literature. A total of 66 publications qualified for inclusion in the survey: 29 articles report experimental investigations, 24 articles are related to numerical or theoretical analysis, and both approaches were used in 13 articles. Many papers deal with upper-room UVGI, AHUs, and ducts. A few papers analyse mobile devices. The evaluation of the dose, as in the case of the definition of irradiance, is reported in a small number of articles. This lack of information makes the scenario imprecise and non-quantitative.
CO2 Mineralized Sequestration and Assistance by Microorganisms in Reservoirs: Development and Outlook
Authors: Ni Shumin , Lv Weifeng , Ji Zemin , Wang Kai
Published: November 2023

The goals of carbon neutrality and peak carbon have officially been proposed; consequently, carbon dioxide utilization and sequestration technology are now in the limelight. Injecting carbon dioxide into reservoirs and solidifying and sequestering it in the form of carbonates after a series of geochemical reactions not only reduces carbon emissions but also prevents carbon dioxide from leaking out of the formation. Carbon dioxide mineralization sequestration, which has good stability, has been considered the best choice for large-scale underground CO2 sequestration. To provide a comprehensive exploration of the research and prospective advancements in CO2 mineralization sequestration within Chinese oil and gas reservoirs, this paper undertakes a thorough review of the mechanisms involved in CO2 mineralization and sequestration. Special attention is given to the advancing front of carbon dioxide mineralization, which is driven by microbial metabolic activities and the presence of carbonic anhydrase within oil and gas reservoirs. The paper presents an in-depth analysis of the catalytic mechanisms, site locations, and structural attributes of carbonic anhydrase that are crucial to the mineralization processes of carbon dioxide. Particular emphasis is placed on delineating the pivotal role of this enzyme in the catalysis of carbon dioxide hydration and the promotion of carbonate mineralization and, ultimately, in the facilitation of efficient, stable sequestration.
Unconventional Reservoir Characterization and Formation Evaluation: A Case Study of a Tight Sandstone Reservoir in West Africa
Authors: Gharavi Amir , Abbas Karrar A. , Hassan Mohamed G. , Haddad Malik , Ghoochaninejad Hesam , Alasmar Reham , Al-Saegh Salam , Yousefi Paria , Shigidi Ihab
Published: November 2023

Unconventional reservoirs, including gas shales and tight gas sands, have gained prominence in the energy sector due to technological advancements and escalating energy demands. The oil industry is eagerly refining techniques to decipher these reservoirs, aiming to reduce data collection costs and uncertainties in reserve estimations. Characteristically, tight reservoirs exhibit low matrix porosity and ultra-low permeability, necessitating artificial stimulation for enhanced production. The efficacy of the stimulation hinges on the organic material distribution, the rock’s mechanical attributes, and the prevailing stress field. Comprehensive petrophysical analysis, integrating standard and specialized logs, core analyses, and dynamic data, is pivotal for a nuanced understanding of these reservoirs. This ensures a reduction in prediction uncertainties, with parameters like shale volume, porosity, and permeability being vital. This article delves into an intricate petrophysical evaluation of the Nene field, a West African unconventional reservoir. It underscores the geological intricacies of the field, the pivotal role of data acquisition, and introduces avant-garde methodologies for depth matching, rock typing, and the estimation of permeability. This research highlights the significance of unconventional reservoir exploration in today’s energy milieu, offering a granular understanding of the Nene field’s geological challenges and proffering a blueprint for analogous future endeavours in unconventional reservoirs.
Three-Phase Transformer Optimization Based on the Multi-Objective Particle Swarm Optimization and Non-Dominated Sorting Genetic Algorithm-3 Hybrid Algorithm
Authors: Shi Baidi , Zhang Liangxian , Jiang Yongfeng , Li Zixing , Xiao Wei , Shang Jingyu , Chen Xinfu , Li Meng
Published: November 2023

The performance of transformers directly determines the reliability, stability, and economy of the power system. The methodologies of minimizing the transformer manufacturing cost under the premise of ensuring performance is of great significance. This paper presented an innovative multi-objective optimization model to analyze the relationship between design parameters and transformer indicators. In addition, the sensitive analysis is conducted to exploit the interaction relationships between design parameters and targets. The reliability of the model was demonstrated in 50 MVA/110 kV and 63 MVA/110 kV prototypes, compared with the actual material usage, short-circuit impedance, and load loss, and the maximum error is less than 7%. Due to this problem having many optimization objectives and the high dimension of variables, a two-stage algorithm called MOPSO-NSGA3 (multi-objective particle swarm optimization and non-dominated sorting genetic algorithm-3) is presented. MOPSO is used to find non-domain solutions within the search space in the first stage, and the solution will be used as prior knowledge to initialize the population in NSGA3. The result shows that this algorithm can be effectively used in multi-objective optimization tasks and best meets the requirements of transformer designs that minimize the short-circuit deviation, operating loss, and manufacturing costs.
Mono-Digestion of 5-Hydroxymethylfurfural Process-Wastewater in Continuously Operated Anaerobic Filters: A Cascade Utilization Approach
Authors: Khan Muhammad Tahir , Krümpel Johannes , Wüst Dominik , Lemmer Andreas
Published: November 2023

A proper remedy for the overexploitation of biomass and biobased materials in the bioeconomy is the valorization of biorefineries’ side streams into meaningful products. Hence, in pursuit of a cascade utilization of renewables, a unique biorefinery byproduct was investigated for its biogas potential, specifically methane, in continuously operated anaerobic filters. For this purpose, 5-Hydroxymethylfurfural process-wastewater, after supplementation of necessary nutrients, was diluted down to 10, 20, 30, 40, and 50 gCOD/L concentrations and thereafter tested individually at 43 °C and 55 °C. Maximum methane conversion efficiency at either temperature was observed for test substrates with 10 gCOD/L and 20 gCOD/L concentrations. At 43 °C, the anaerobic filters exhibited their highest biogas yields when supplied with the 30 gCOD/L feedstock. Further exposure of the mesophilic and thermophilic consortia to the ensuing 5-Hydroxymethylfurfural process-wastewater dilutions compromised the stability of the anaerobic process due to the soaring concentrations of short-chained volatile fatty acids. The supplementation of necessary nutrients to unlock the methane potential of the given recalcitrant substrate appears insufficient. Techniques like micro aeration, photolysis, or the use of activated carbon in the fixed bed might have the ability to enhance the biochemical methane conversion of such feedstock; otherwise, the introduction of trace elements alone may be adequate if aiming for platforms (volatile fatty acids) via anaerobic technologies.
Calculation of the Potential Biogas and Electricity Values of Animal Wastes: Turkey and Poland Case
Authors: Ertop Hasan , Atilgan Atilgan , Kocięcka Joanna , Krakowiak-Bal Anna , Liberacki Daniel , Saltuk Burak , Rolbiecki Roman
Published: November 2023

This research aimed to analyze the potential amount of electrical energy from biogas energy obtained from animal wastes in Turkey and Poland. Animal waste values were calculated by taking into account the recommended literature values. In determining the biomass energy potential of livestock enterprises in Turkey and Poland, FAO’s 2012–2021 data were taken into account. The animal breeds selected as material in this study were cattle, goat, sheep, chicken, duck, goose, turkey, horse, pig, mule and donkey. Considering 10-year calculations, the potential amount of biogas energy that can be obtained from animal wastes for Turkey is 28,845,975 GJ, which is equivalent to 8,105,058 MWh of electrical energy. In Poland, the potential amount of biogas energy that can be generated from animal waste is 13,999,612 GJ, which is equivalent to 3,902,020 MWh of electricity. Moreover, it is estimated that the percentage of the potential amount of electricity to be obtained in 2021 to cover the amount of electricity consumed is 0.303% for Turkey and 0.392% for Poland. For 2021, the amount of economic gains that can be from electricity obtained was also calculated, and it was determined that this value can be 78,650,302 Euro for Turkey and 62,182,435 Euro for Poland. At the same time, it was calculated that the electricity needs of 406,170 houses in Turkey and 171,958 houses in Poland can be met in 2021. As a result, it is thought that the potential electricity to be obtained will contribute to determining energy gains and investment plans for biogas plants.
The Effect of High-Energy Ball Milling of Montmorillonite for Adsorptive Removal of Cesium, Strontium, and Uranium Ions from Aqueous Solution
Authors: Kovalchuk Iryna , Zakutevskyy Oleg , Sydorchuk Volodymyr , Diyuk Olena , Lakhnik Andrey
Published: November 2023

Clay minerals are widely used to treat groundwater and surface water containing radionuclides. In our study, the method of mechanochemical activation for increasing the sorption capacity of the natural clay mineral montmorillonite was used. By adjusting the grinding time, the increasing sorption parameters of mechanochemically activated montmorillonite were determined. X-ray diffraction method, scanning electron microscopy, and the determination of the specific surface by low-temperature adsorption–desorption of nitrogen to characterize the natural and mechanochemical-activated montmorillonites were used. It was established that the maximal sorption of uranium, strontium, and cesium is found for montmorillonite after mechanochemical treatment for 2 h. It is shown that the filling of the surface of montmorillonite with ions of different natures occurs in various ways during different times of mechanochemical treatment. The appropriateness of the Langmuir and Freundlich models for the sorption parameters of uranium, strontium, and cesium ions on montmorillonite after its mechanochemical activation was established. The effect of natural organic substances—humic acids—on the efficiency of water purification from uranium on mechanoactivated montmorillonite was studied. The obtained sorbents can be effectively used for the removal of trace amounts of radionuclides of different chemical natures (uranium, cesium, and strontium) from polluted surface and ground waters.
Analysis and Design Methodology of Radial Flux Surface-Mounted Permanent Magnet Synchronous Motors
Authors: Suriano-Sánchez Sergio I. , Ponce-Silva Mario , Olivares-Peregrino Víctor H. , De León-Aldaco Susana E. , Claudio-Sánchez Abraham , Cortés-García Claudia
Published: November 2023

Permanent magnet motors have become very important in recent years due to the popularization of electric vehicles in the context of the efforts to transition to zero-emission transportation. This has encouraged researchers and hobbyists to learn about electric motor design. However, designing electric motors is not a simple task, as the information to achieve it is not easily available to everyone and it is usually complicated to understand. For that reason, this paper presents the equations and a basic process to design radial flux surface-mounted PM synchronous motors. This design method is the result of combining and organizing information from previous publications to create a relatively simple design guide. The result is a table of equations and a series of general guidelines that were verified by designing and simulating a 500 W eight-pole 2.6 Nm average torque dual-rotor motor and a 20 W four-pole 106 mNm single-rotor motor. The simulations validated the equations and the design method presented in this paper to be used by those interested in the field of electric motors and vehicles; therefore, in the future, others may contribute with improvements, particularizations or optimizations of this methodology, or even create their own.
Remarks on Constitutive Modeling of Granular Materials
Authors: Massoudi Mehrdad
Published: November 2023

In this paper, we provide a brief overview of certain fundamental concepts which can be used to derive constitutive relations for the stress tensor of granular materials. These include concepts such as dilatancy, cohesion, yield criterion, shear banding, etc. The focus will be on the constitutive relations which are used in the so-called ‘frictional flow’ or ‘slow flow’ regime as opposed to the rapid flow regime; in the slow flow regime the material is about to yield or has just yielded and the flow has been initiated. This type of flow occurs in the storage of grains, etc., in silos and bins or hoppers after the valves/gates are opened. The techniques of continuum mechanics are used to discuss constitutive relations where the effects of non-linearities such as yield stress, dilatancy, density gradients, etc., are important.
Global Bibliometric Analysis of Research on the Application of Biochar in Forest Soils
Authors: Chen Zhufeng , Gao Yaqian , Chen Jiaxian , Yang Ling , Zeng Shucai , Su Yan , Li Jiyue , He Qian , Qiu Quan
Published: November 2023

Considering the impacts of global climate change, paths for sustainable development are of particular importance. Biochar has multiple advantages, including but not limited to climate change mitigation, waste management, soil fertility improvement, and pollution remediation. Forest soils play a significant role in terrestrial ecosystems. The application of biochar in forest soils (ABFS) is therefore considered an essential tool for improving soil quality, capturing carbon, and reducing greenhouse gas emissions. The Web of Science Core Collection database was utilized for the bibliometric analysis of ABFS publications published between 2002 and 2022. Three bibliometric software were used to analyze bibliometrics, networks, and research directions for ABFS: Bibliometrix, VOSviewer, and CiteSpace. The analysis shows that research on ABFS is always rapidly developing. Research on ABFS is engaged globally in a complex network of collaborations, and the main research has occurred in China and the United States. Collaboration among authors is relatively diffuse. Research on ABFS involves interdisciplinary integration. In the early stages of research, the origin of biochar (history and boreal forests) and its characteristics (dynamics, nitrogen content, and chemical composition) were the focus of attention. As research progressed, more attention was given to ABFS (carbon, organic matter, vegetation, and heavy metals). Our research shows that while ABFS research has a certain history, its development trend has been consistently upward and shows no signs of declining. Thus, future research will likely concentrate on ABFS. Due to the complexity of biochar functions, ample research opportunities exist in ABFS.
Impact of Chemical Composition on Eucalyptus Wood Clones for Sustainable Energy Production
Authors: Vieira Túlio A. S. , Trugilho Paulo F. , Carabineiro Sónia A. C. , Zanuncio Antônio José Vinha , Carvalho Amélia Guimarães , Branco-Vieira Monique
Published: November 2023

The energy potential of wood biomass is significantly shaped by its chemical composition. Analyzing the chemical composition of wood biomass and understanding the correlations between these parameters and wood combustibility are essential stages in the selection process of Eucalyptus clones tailored for firewood production and energy generation. In this study, we aimed to evaluate the impact of chemical composition on the direct combustibility of Eucalyptus clones. We examined the structural chemical composition and conducted proximate analysis, including fixed carbon, volatile material, and ash, to investigate the relationship between proximate composition and wood combustibility parameters. Our findings revealed significant correlations between wood chemical composition and combustibility parameters. In particular, lignin content, ethanol-soluble extractives, and xylose demonstrated inverse relationships with the parameters of maximum combustion rate, combustion characteristic index, and ignition index. Conversely, holocellulose content, cold-water-soluble extractives, and glucose exhibited direct correlations with the same combustibility parameters. Furthermore, fixed carbon and volatile matter contents demonstrated direct and inverse correlations, respectively, with ignition temperature. These findings have significant implications for enhancing the efficiency and sustainability of biomass energy production.
Forest Soil Carbon Cycle in Response to Global Change
Authors: Wang Minhuang , Xie Jinsheng , Lyu Maokui
Published: November 2023

Forests constitute a critical component of terrestrial carbon reservoirs, with a substantial amount of carbon stored in soil as organic carbon, holding significant potential for climate change mitigation [...]
Latitudinal Patterns of Leaf Carbon, Nitrogen, and Phosphorus Stoichiometry in Phyllostachys propinqua McClure across Northern China
Authors: Chen Lei , Li Le , Pei Nancai , Zhu Lin , Li Shan , Li Xiaohua , Zhang Xuan , Li Juan , Huang Biao , Qin Xinsheng
Published: November 2023

Spatial patterns of leaf carbon (C), nitrogen (N), and phosphorus (P) stoichiometry play a pivotal role in the comprehension of terrestrial ecosystem dynamics, nutrient cycling, in responses to contemporary global climate change, and the evolutionary trajectories of leaf morphology and function. These patterns are not only solely shaped by plant and community composition, but also are profoundly influenced by environmental factors. Therefore, there is a compelling need for an in-depth investigation into individual species to discern the intricate impacts of soil and climate on leaf stoichiometry. In this study, we assessed the C, N, and P concentrations of mature leaves from 20 Phyllostachys propinqua populations in the urban forest across northern China covering a substantial latitudinal gradient. Our findings revealed that the average leaf concentrations of C, N, and P in P. propinqua were recorded at 0.46 g g−1, 23.19 mg g−1, and 1.40 mg g−1, respectively. Notably, we observed that leaf C and P concentrations, as well as the C:N ratios, exhibited significant increases with rising latitude. Conversely, leaf N concentrations and N:P ratios exhibited a marked decline with increasing latitude. These patterns were primarily driven by climate factors such as mean annual temperature (MAT) and lowest temperature (LT). In contrast, we found that only leaf C concentrations were correlated with soil N levels. These results underscored the differential spatial distribution of leaf C, N, and P stoichiometry in urban forest across northern China, predominantly instigated by climatic factors, particularly in regions characterized by lower temperatures. Our findings further suggest that P. propinqua enhances its adaptability to low-temperature environments by elevating leaf C and P concentrations.
Ostrowski-Type Fractional Integral Inequalities: A Survey
Authors: Tariq Muhammad , Ntouyas Sotiris K. , Ahmad Bashir
Published: November 2023

This paper presents an extensive review of some recent results on fractional Ostrowski-type inequalities associated with a variety of convexities and different kinds of fractional integrals. We have taken into account the classical convex functions, quasi-convex functions, (ζ,m)-convex functions, s-convex functions, (s,r)-convex functions, strongly convex functions, harmonically convex functions, h-convex functions, Godunova-Levin-convex functions, MT-convex functions, P-convex functions, m-convex functions, (s,m)-convex functions, exponentially s-convex functions, (β,m)-convex functions, exponential-convex functions, ζ¯,β,γ,δ-convex functions, quasi-geometrically convex functions, s−e-convex functions and n-polynomial exponentially s-convex functions. Riemann–Liouville fractional integral, Katugampola fractional integral, k-Riemann–Liouville, Riemann–Liouville fractional integrals with respect to another function, Hadamard fractional integral, fractional integrals with exponential kernel and Atagana-Baleanu fractional integrals are included. Results for Ostrowski-Mercer-type inequalities, Ostrowski-type inequalities for preinvex functions, Ostrowski-type inequalities for Quantum-Calculus and Ostrowski-type inequalities of tensorial type are also presented.
An Algorithm for Crack Detection, Segmentation, and Fractal Dimension Estimation in Low-Light Environments by Fusing FFT and Convolutional Neural Network
Authors: Cheng Jiajie , Chen Qiunan , Huang Xiaocheng
Published: November 2023

The segmentation of crack detection and severity assessment in low-light environments presents a formidable challenge. To address this, we propose a novel dual encoder structure, denoted as DSD-Net, which integrates fast Fourier transform with a convolutional neural network. In this framework, we incorporate an information extraction module and an attention feature fusion module to effectively capture contextual global information and extract pertinent local features. Furthermore, we introduce a fractal dimension estimation method into the network, seamlessly integrated as an end-to-end task, augmenting the proficiency of professionals in detecting crack pathology within low-light settings. Subsequently, we curate a specialized dataset comprising instances of crack pathology in low-light conditions to facilitate the training and evaluation of the DSD-Net algorithm. Comparative experimentation attests to the commendable performance of DSD-Net in low-light environments, exhibiting superlative precision (88.5%), recall (85.3%), and F1 score (86.9%) in the detection task. Notably, DSD-Net exhibits a diminutive Model Size (35.3 MB) and elevated Frame Per Second (80.4 f/s), thereby endowing it with the potential to be seamlessly integrated into edge detection devices, thus amplifying its practical utility.
Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights
Authors: Nagori Kushagra , Nakhate Kartik T. , Yadav Krishna , Ajazuddin  , Pradhan Madhulika
Published: November 2023

Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient therapeutic strategies are essential. Moreover, the progression of the disease is unaffected by the pharmaceutical approaches discovered to date. Additionally, the failure of over 200 potential drug candidates in clinical trials over the past decade suggests the complexity and difficulty of both the disease and its underlying causes. Therefore, research focused on medicinal plant-based natural products in the search for novel neuroprotective therapeutic candidates for AD is essential. Indeed, several scientific investigations have demonstrated the efficacy of many medicinal plants and their principal phytochemicals in the treatment of AD. This review article covered the pathophysiological mechanisms of AD, the necessity for natural products as anti-AD treatments, and the most recent preclinical studies revealing the function of neuroprotective medicinal plants and their bioactive compounds in the effective management of AD. In addition, the review also presents clinical trial data of promising anti-AD formulations/agents of plant origin. Revealing recent findings and highlighting the clinical trial data related to the development of new treatments for AD would promote further research in this field and pave the way for the development of more effective and safe treatments for this debilitating disease.
Goals of Restoration Ecology and the Role of Grasses in the Processes as Seen in Southeastern Africa Restoration Projects
Authors: Lubke Roy
Published: November 2023

The goals of a “restoration” programme are often not clearly defined, which may radically influence the course of the change effected by the “restoration”. In this paper, I examine many restoration studies worldwide, the goals and the practice that was followed. Grasses often play an important role in both the succession and restoration processes. In Johannesburg, South Africa, wind-blown dust caused by gold mining was a problem in the early 20th century, so the goal was to stabilise the tailings. This was achieved by establishing vegetation on the dumps or revegetation of the land on which the tailings were deposited. Stabilisation of the Cape Flats was the goal in the late 19th century to allow easy movement along sandy roads in the region and marram grass was introduced from Europe specifically for this purpose. Revegetation with a different vegetation type is often a logical option where land use is of paramount importance. Replacement with crop plants or grasses is where the previous vegetation is replaced by an alternative land use that will be of benefit to the local people. The terms “rehabilitation” and “restoration” are often used interchangeably. Early researchers on the subject pointed out that rehabilitation is on the trajectory to full restoration or the original former state of the degraded site. In this review, the rehabilitation processes are discussed following dune mining in South Africa and at sites in Mozambique.
Cumulative Incidence of All-Cause Knee Injury, Concussion, and Stress Fracture among Transgender Patients on Gender-Affirming Hormone Therapy: An Exploratory Retrospective Cohort Study
Authors: Miro Emily W. , Taylor Eliza , Curtin Andrew , Newman Michael G. , Ose Dominik , Knox Jordan
Published: November 2023

Previous research has shown a discrepancy in incidences of knee injuries, stress fractures, and concussions between cisgender men and women. Little is known regarding the incidence of musculoskeletal injuries among patients on gender-affirming hormone therapy (GAHT). This retrospective cohort study examines cumulative incidence of knee injuries, concussions, and stress fracture injuries among transgender patients on GAHT at one health system from 2011–2020. Using relevant ICD-9 and 10 codes, incidences of knee injury, concussion, and stress fracture were calculated. Cohorts included 1971 transgender and 3964 cisgender patients. Transgender patients had significantly higher incidence of all-cause knee injuries over the study period, 109 (5.5%) versus 175 (4.4%) (p < 0.001; OR: 2.14, 95% CI [1.17–3.92]). Subgroup analysis showed significantly higher incidence of knee injuries among cisgender men (5.6%) versus cisgender women (4.1%) (p = 0.042) and among transgender women (6.6%) versus cisgender women (4.1%) (p = 0.005). There were no significant differences between incidences of concussion and stress fracture between groups. This sample showed that patients on GAHT had increased cumulative incidences of all-cause knee injury compared to controls but similar cumulative incidences of concussion and bone-stress injuries. Transgender women on exogenous estrogen had significantly higher cumulative incidences of all-cause knee injuries compared to cisgender women.
Integrated Human Exposure to Air Pollution: A Step Further
Authors: Canha Nuno , Diapouli Evangelia , Almeida Susana Marta
Published: November 2023

Along with climate change, air pollution is one of the biggest environmental problems affecting everyone in the world today [...]
How the Presence of Crystalline Phase Affects Structural Relaxation in Molecular Liquids: The Case of Amorphous Indomethacin
Authors: Svoboda Roman , Pakosta Marek , Doležel Petr
Published: November 2023

The influence of partial crystallinity on the structural relaxation behavior of low-molecular organic glasses is, contrary to, e.g., polymeric materials, a largely unexplored territory. In the present study, differential scanning calorimetry was used to prepare a series of amorphous indomethacin powders crystallized to various extents. The preparations stemmed from the two distinct particle size fractions: 50–125 µm and 300–500 µm. The structural relaxation data from the cyclic calorimetric measurements were described in terms of the phenomenological Tool–Narayanaswamy–Moynihan model. For the 300–500 µm powder, the crystalline phase forming dominantly on the surface led to a monotonous decrease in the glass transition by ~6 °C in the 0–70% crystallinity range. The activation energy of the relaxation motions and the degree of heterogeneity within the relaxing matrix were not influenced by the increasing crystallinity, while the interconnectivity slightly increased. This behavior was attributed to the release of the quenched-in stresses and to the consequent slight increase in the structural interconnectivity. For the 50–125 µm powder, distinctly different relaxation dynamics were observed. This leads to a conclusion that the crystalline phase grows throughout the bulk glassy matrix along the internal micro-cracks. At higher crystallinity, a sharp increase in Tg, an increase in interconnectivity, and an increase in the variability of structural units engaged in the relaxation motions were observed.
Genetic Background of Epilepsy and Antiepileptic Treatments
Authors: Borowicz-Reutt Kinga , Czernia Julia , Krawczyk Marlena
Published: November 2023

Advanced identification of the gene mutations causing epilepsy syndromes is expected to translate into faster diagnosis and more effective treatment of these conditions. Over the last 5 years, approximately 40 clinical trials on the treatment of genetic epilepsies have been conducted. As a result, some medications that are not regular antiseizure drugs (e.g., soticlestat, fenfluramine, or ganaxolone) have been introduced to the treatment of drug-resistant seizures in Dravet, Lennox-Gastaut, maternally inherited chromosome 15q11.2-q13.1 duplication (Dup 15q) syndromes, and protocadherin 19 (PCDH 19)-clusterig epilepsy. And although the effects of soticlestat, fenfluramine, and ganaxolone are described as promising, they do not significantly affect the course of the mentioned epilepsy syndromes. Importantly, each of these syndromes is related to mutations in several genes. On the other hand, several mutations can occur within one gene, and different gene variants may be manifested in different disease phenotypes. This complex pattern of inheritance contributes to rather poor genotype–phenotype correlations. Hence, the detection of a specific mutation is not synonymous with a precise diagnosis of a specific syndrome. Bearing in mind that seizures develop as a consequence of the predominance of excitatory over inhibitory processes, it seems reasonable that mutations in genes encoding sodium and potassium channels, as well as glutamatergic and gamma-aminobutyric (GABA) receptors, play a role in the pathogenesis of epilepsy. In some cases, different pathogenic variants of the same gene can result in opposite functional effects, determining the effectiveness of therapy with certain medications. For instance, seizures related to gain-of-function (GoF) mutations in genes encoding sodium channels can be successfully treated with sodium channel blockers. On the contrary, the same drugs may aggravate seizures related to loss-of-function (LoF) variants of the same genes. Hence, knowledge of gene mutation–treatment response relationships facilitates more favorable selection of drugs for anticonvulsant therapy.
Genetic Concordance in Primary Cutaneous Melanoma and Matched Metastasis: A Systematic Review and Meta-Analysis
Authors: Kerkour Thamila , Zhou Catherine , Hollestein Loes , Mooyaart Antien
Published: November 2023

Studying primary melanoma and its corresponding metastasis has twofold benefits. Firstly, to better understand tumor biology, and secondly, to determine which sample should be examined in assessing drug targets. This study systematically analyzed all the literature on primary melanoma and its matched metastasis. Following PRISMA guidelines, we searched multiple medical databases for relevant publications from January 2000 to December 2022, assessed the quality of the primary-level studies using the QUIPS tool, and summarized the concordance rate of the most reported genes using the random-effects model. Finally, we evaluated the inter-study heterogeneity using the subgroup analysis. Thirty-one studies investigated the concordance of BRAF and NRAS in 1220 and 629 patients, respectively. The pooled concordance rate was 89.4% [95% CI: 84.5; 93.5] for BRAF and 97.8% [95% CI: 95.8; 99.4] for NRAS. When high-quality studies were considered, only BRAF mutation status consistency increased. Five studies reported the concordance status of c-KIT (93%, 44 patients) and TERT promoter (64%, 53 patients). Lastly, three studies analyzed the concordance of cancer genes involved in the signaling pathways, apoptosis, and proliferation, such as CDKN2A (25%, four patients), TP53 (44%, nine patients), and PIK3CA (20%, five patients). Our study found that the concordance of known drug targets (mainly BRAF) during melanoma progression is higher than in previous meta-analyses, likely due to advances in molecular techniques. Furthermore, significant heterogeneity exists in the genes involved in the melanoma genetic makeup; although our results are based on small patient samples, more research is necessary for validation.
Pathogenic Variants and Genotypes of the CFTR Gene in Russian Men with Cystic Fibrosis and CBAVD Syndrome
Authors: Chernykh Vyacheslav , Krasovsky Stanislav , Solovova Olga , Adyan Tagui , Stepanova Anna , Marnat Ekaterina , Shtaut Maria , Sedova Anna , Sorokina Tatyana , Beskorovainaya Tatyana , Kondratyeva Elena , Shchagina Olga , Polyakov Aleksandr
Published: November 2023

Pathogenic CFTR variants cause cystic fibrosis (CF), and CF-related disorders (CF-RD), including bilateral aplasia of the vas deferens (CBAVD). The spectrum of clinical manifestations depends on the CFTR genotype. The frequency and spectrum of the CFTR variants vary between populations and clinical groups. CFTR variants and genotypes were analyzed in Russian men with CF (n = 546) and CBAVD syndrome (n = 125). Pathogenic variants were detected in 93.95% and 39.2% of the CF and CBAVD alleles, respectively. The most frequent c.1521_1523del (F508del; p.Phe508del) variant was found in 541 (49.5%) CF alleles. A total of 162 CFTR genotypes were revealed in CF patients, including 152 homozygous and 394 compound-heterozygous. The most common CF-genotype was F508del/F508del (24.9%). Other frequent CF-genotypes were F508del/3849+10kbC>T, F508del/CFTRdele2,3, and F508del/E92K. CF-causing variants and/or 5T allele were found in 88% of CBAVD patients: 5T/CFTRmut (48.0%), CFTRmut/N (17.6%), CFTRmut/CFTRmut (6.4%), 5T/5T (10.4%), 5T/N (5.6%) and N/N (12.0%), with the most common CBAVD-genotype being F508del/5T (29.6%). The allele frequencies of F508del, CFTRdele2,3 394delTT, and 3849+10kbC>T were significantly higher in CF patients. L138ins/L138ins, 2184insA/E92K, and L138ins/N genotypes were found in CBAVD, but not in CF patients. The results indicate certain differences in the frequency of some CFTR variants and genotypes in Russian CF and CBAVD patients.
Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies
Authors: Alkhalifa Amer E. , Al-Ghraiybah Nour F. , Odum Julia , Shunnarah John G. , Austin Nataleigh , Kaddoumi Amal
Published: November 2023

The blood–brain barrier (BBB) is a unique and selective feature of the central nervous system’s vasculature. BBB dysfunction has been observed as an early sign of Alzheimer’s Disease (AD) before the onset of dementia or neurodegeneration. The intricate relationship between the BBB and the pathogenesis of AD, especially in the context of neurovascular coupling and the overlap of pathophysiology in neurodegenerative and cerebrovascular diseases, underscores the urgency to understand the BBB’s role more deeply. Preserving or restoring the BBB function emerges as a potentially promising strategy for mitigating the progression and severity of AD. Molecular and genetic changes, such as the isoform ε4 of apolipoprotein E (ApoEε4), a significant genetic risk factor and a promoter of the BBB dysfunction, have been shown to mediate the BBB disruption. Additionally, receptors and transporters like the low-density lipoprotein receptor-related protein 1 (LRP1), P-glycoprotein (P-gp), and the receptor for advanced glycation end products (RAGEs) have been implicated in AD’s pathogenesis. In this comprehensive review, we endeavor to shed light on the intricate pathogenic and therapeutic connections between AD and the BBB. We also delve into the latest developments and pioneering strategies targeting the BBB for therapeutic interventions, addressing its potential as a barrier and a carrier. By providing an integrative perspective, we anticipate paving the way for future research and treatments focused on exploiting the BBB’s role in AD pathogenesis and therapy.
Design, Synthesis, and Antitumor Activity Evaluation of Proteolysis-Targeting Chimeras as Degraders of Extracellular Signal-Regulated Kinases 1/2
Authors: Pan Pengming , He Yichao , Geng Tongtong , Li Zhongtang , Li Zhongjun , Meng Xiangbao
Published: November 2023

Inhibition of the extracellular signal-regulated kinases 1/2 (ERK1/2) alone or in combination with other targets has emerged as a promising treatment strategy for a variety of human tumors. In addition to the development of inhibitors, the development of ERK1/2 degraders is an alternative approach to decrease its activity. We synthesized proteolysis-targeting chimeras (PROTACs) as effective ERK1/2 degraders, among which B1-10J showed high degradative activity, with DC50 of 102 nM and cytotoxic IC50 of 2.2 μM against HCT116 cells. Moreover, B1-10J dose-dependently inhibited tumor cell migration. Xenograft experiments in nude mice demonstrated that B1-10J inhibited HCT116 tumor cell growth and achieved significant regression of tumors at a daily dose of 25 mg/kg.