bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, Attitude and Practice of Hospital Pharmacists in Central China Towards Adverse Drug Reaction Reporting: A Multicenter Cross‐Sectional Study
Authors: Hu Wen , Tao Yun , Lu Yun , Gao Suyu , Wang Xuanxuan , Li Wenjing , Jiang Qiaoli , Lin Likai , Sun Feng , Cheng Hong
Published: March 2022

Background: Healthcare professionals’ knowledge and attitudes towards adverse drug reactions (ADRs) and ADR reporting play a significant role in pharmacovigilance. This study aims to investigate the gap between knowledge and practice in ADR reporting among hospital pharmacists.

Methods: This study is a multi-center, cross-sectional study based on a questionnaire survey. A semi-structured questionnaire was developed including knowledge, attitudes, and practices (KAP) towards ADR reporting. From October to November 2021, questionnaires were filled out on the internet by hospital pharmacists from a central province of China. The data analysis used a one-way ANOVA to analyze the differences between the pharmacist’s characteristics and knowledge and attitude, respectively. The ordinal logistic regression method was used to analyze the predictors of practice.

Results: A total of 1,026 valid questionnaires from 512 medical institutions were collected. It was found that 88.8% of participants have a clear understanding of the ADR definition, while 59.6% of them have misunderstandings about the reporting time of new and serious adverse reactions. Most pharmacists showed positive attitudes towards ADR reporting. Higher education background, higher professional title, attending training, and clinical pharmacist resulted in higher knowledge scores. Higher education background, shorter working years, attending training, and from non-tertiary hospital related to higher attitude scores. In terms of practice, age, hospital type, working years, training, and pharmacist type all have significant associations with practice scores. Pharmacists’ knowledge score and attitude score were significant predictors of practice score with OR being 1.19 (95% CI: 1.06, 1.33) and 1.04 (95% CI: 1.005, 1.07).

Conclusion: Although most hospital pharmacists showed positive attitudes towards ADR reporting, their knowledge and practice were still insufficient. Hospital pharmacists’ knowledge and attitude are associated with their practice towards ADR reporting. The training had a significant impact on the pharmacist’s knowledge, attitude, and practice.
Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute Inflammation
Authors: Wu Yue , Li Kuangyu , Zeng Maolin , Qiao Boyang , Zhou Benhong
Published: March 2022

Background: Gallic acid (GA) is a natural small-molecule polyphenol having a wide range of pharmacological activities. Until now, some works have studied the effect and the mechanisms of GA against inflammation. However, whether or how gallic acid regulates the downstream metabolic disorder against acute inflammation remains unclear. The present study explored the protective effect and the potential mechanism of GA on acute inflammation through the metabolomics approach.

Methods: An acute inflammation rat model was induced by local injection of carrageenin. Local swelling on paw and serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were assessed in Control, Model and Gallic acid groups, respectively. Serum metabolomics based on high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) was also established to collect rats’ metabolic profiles and explore the metabolic changes related to GA pretreatment.

Results: Compared to the Modal group, local pain, redness, and swelling induced by carrageenin were significantly alleviated in GA groups in addition to the dose-dependent decreases of TNF-α and IL-6. Metabolomics analysis found significant alterations in metabolic signatures between the carrageenin-induced inflammation and control groups. Twelve potential biomarkers were further identified in acute inflammation by principal component analysis (PCA) and partial least squares discrimination analysis (PLS-DA). In addition, when rats were pretreated with gallic acid, serum levels of eleven biomarkers were observed to restore partially. Metabolic pathway and networks analysis revealed that GA might invert the pathological process of acute inflammation by regulating the key biomarkers involved in linoleic acid metabolism, ascorbate and aldarate metabolism, pentose and glucuronate interconversions, and arachidonic acid (AA) metabolism pathways.

Conclusion: The study elucidates the protective effect of gallic acid against acute inflammation and its possible regulating mechanism from a metabolomic perspective. These results could provide a theoretical basis for clarifying gallic acid’s mechanism and potential medicinal value in curing inflammation disorder in the clinic.
Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1
Authors: Hu Yan , Zhou Yile , Yang Yajie , Tang Haihong , Si Yuan , Chen Zhouyi , Shi Yi , Fang Hao
Published: March 2022

Objectives: Diabetes is an independent risk factor for dementia. Mitochondrial dysfunction is a critical player in diabetes and diabetic complications. The present study aimed to investigate the role of mitochondrial dynamic changes in diabetes-associated cognitive impairment.

Methods: Cognitive functions were examined by novel object recognition and T-maze tests. Mice hippocampi were collected for electron microscopy and immunofluorescence examination. Neuron cell line HT22 and primary hippocampal neurons were challenged with high glucose in vitro. Mitotracker-Red CM-H2X ROS was used to detect mitochondrial-derived free radicals.

Results: Diabetic mice exhibited memory loss and spatial disorientation. Electron microscopy revealed that diabetic mice had larger synaptic gaps, attenuated postsynaptic density and fewer dendritic spines in the hippocampus. More round-shape mitochondria were observed in hippocampal neurons in diabetic mice than those in control mice. In cultured neurons, high glucose induced a high phosphorylated level of dynamin-related protein 1 (DRP1) and increased oxidative stress, resulting in cell apoptosis. Inhibition of mitochondrial fission by Mdivi-1 and metformin significantly decreased oxidative stress and prevented cell apoptosis in cultured cells. Treatment of Mdivi-1 and metformin restored cognitive function in diabetic mice.

Conclusion: Metformin restores cognitive function by inhibiting mitochondrial fission, reducing mitochondrial-derived oxidative stress, and mitigating neuron loss in hippocampi of diabetic mice. The protective effects of metformin shed light on the therapeutic strategy of cognitive impairment.
A Novel N-Arylpyridone Compound Alleviates the Inflammatory and Fibrotic Reaction of Silicosis by Inhibiting the ASK1-p38 Pathway and Regulating Macrophage Polarization
Authors: Fan Mingming , Xiao Huijuan , Song Dingyun , Zhu Lili , Zhang Jie , Zhang Xinran , Wang Jing , Dai Huaping , Wang Chen
Published: March 2022

Silicosis is one of the potentially fatal occupational diseases characterized by respiratory dysfunction, chronic interstitial inflammation, and fibrosis, for which treatment options are limited. Previous studies showed that a novel N-arylpyridone compound named AKEX0011 exhibited anti-inflammatory and anti-fibrotic effects in bleomycin-induced pulmonary fibrosis; however, it is unknown whether it could also be effective against silicosis. Therefore, we sought to investigate the preventive and therapeutic roles of AKEX0011 in a silicosis rodent model and in a silica-stimulated macrophage cell line. In vivo, our results showed that AKEX0011 ameliorated silica-induced imaging lung damages, respiratory dysfunction, reduced the secretion of inflammatory and fibrotic factors (TNF-α, IL-1β, IL-6, TGF-β, IL-4, and IL-10), and the deposition of fibrosis-related proteins (collagen I, fibronectin, and α-SMA), regardless of early or advanced therapy. Specifically, we found that AKEX0011 attenuated silicosis by inhibiting apoptosis, blocking the ASK1-p38 MAPK signaling pathway, and regulating polarization of macrophages. In vitro, AKEX0011 inhibited macrophages from secreting inflammatory cytokines and inhibited apoptosis of macrophages in pre-treated and post-treated models, concurrent with blocking the ASK1-p38 pathway and inhibiting M1 polarization. Collectively, AKEX0011, as a novel N-arylpyridone compound, exerted protective effects for silica-induced pulmonary inflammation and fibrosis both in vivo and in vitro, and hence, it could be a strong drug candidate for the treatment of silicosis.
The Role of Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases
Authors: Jeong Jiung , Choi Young Joon , Lee Heung Kyu
Published: March 2022

Uncontrolled acute inflammation progresses to persistent inflammation that leads to various chronic inflammatory diseases, including asthma, Crohn’s disease, rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. CD4+ T cells are key immune cells that determine the development of these chronic inflammatory diseases. CD4+ T cells orchestrate adaptive immune responses by producing cytokines and effector molecules. These functional roles of T cells vary depending on the surrounding inflammatory or anatomical environment. Autophagy is an important process that can regulate the function of CD4+ T cells. By lysosomal degradation of cytoplasmic materials, autophagy mediates CD4+ T cell-mediated immune responses, including cytokine production, proliferation, and differentiation. Furthermore, through canonical processes involving autophagy machinery, autophagy also contributes to the development of chronic inflammatory diseases. Therefore, a targeted intervention of autophagy processes could be used to treat chronic inflammatory diseases. This review focuses on the role of autophagy via CD4+ T cells in the pathogenesis and treatment of such diseases. In particular, we explore the underlying mechanisms of autophagy in the regulation of CD4+ T cell metabolism, survival, development, proliferation, differentiation, and aging. Furthermore, we suggest that autophagy-mediated modulation of CD4+ T cells is a promising therapeutic target for treating chronic inflammatory diseases.
Soliton Dynamics of the Generalized Shallow Water Like Equation in Nonlinear Phenomenon
Authors: Akram Ghazala , Sadaf Maasoomah , Khan M. Atta Ullah
Published: March 2022

The generalized shallow water like equation is investigated in this research paper. Exact solutions of generalized shallow water like equation are extracted using modified auxiliary equation (MAE) method and extended (G′G2)-expansion method. Many novel soliton solutions are obtained using these methods. The retrieved solution of governing model include rational, trigonometric and hyperbolic functions. The 3D graphs, 2D contour graphs and line graphs of obtained solutions are plotted using symbolic software such as Maple. The aim of plotting graphs is to demonstrate the dynamical behavior of acquired solutions. Thus, this study investigate the exact soliton solutions of generalized shallow water like using proposed methods.
Realization of Tunable Highly-Efficient Quantum Routing in Chiral Waveguides
Authors: Yan Guo-An , Lu Hua
Published: March 2022

The chiral interaction between single photons in waveguides and quantum emitters has gained considerable attention. Here, we proposed a tunable quantum routing scheme with a chiral quantum system by coupling an emitter to two chiral waveguides. Conventional quantum routers can only be achieved with each port output probability no larger than 25%. But our scheme can transfer quantum information arbitrarily from an input port to another, and each port’s output probability is 100%. Besides, we investigated the influence of the Purcell factor in quantum routing properties. No matter how to change the size of the directionalities Sj or set a specific value to the dissipation of the emitter, we always found that the quantum routing has very high efficiency. Moreover, we also used a superconducting qubit coupled to two resonators to show the present scheme is pretty feasible for experimental implementation.
Mucus Clearance Strategies in Mechanically Ventilated Patients
Authors: Goetz Ryan L. , Vijaykumar Kadambari , Solomon George M.
Published: March 2022

The use of airway clearance strategies as supplementary treatment in respiratory disease has been best investigated in patients with cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (NCFBE), conditions which are traditionally characterized by excessive mucus stasis and mucociliary dysfunction. A variety of airway clearance therapies both pharmacological and non-pharmacological have been shown to ameliorate disease progression in this population and have hence been assimilated into routine respiratory care. This self-propagating cycle of mucus retention and airway damage leading to chronic inflammation and infections can also be applied to patients with respiratory failure requiring mechanical ventilation. Furthermore, excessive trachea-bronchial secretions have been associated with extubation failure presenting an opportunity for intervention. Evidence for the use of adjunctive mucoactive agents and other therapies to facilitate secretion clearance in these patients are not well defined, and this subgroup still remains largely underrepresented in clinical trials. In this review, we discuss the role of mucus clearance techniques with a proven benefit in patients with CF and NCFBE, and their potential role in patients requiring mechanical ventilation while highlighting the need for standardization and adoption of mucus clearance strategies in these patient populations.
Effects of Cycling Intensity on Acute Signaling Adaptations to 8-weeks Concurrent Training in Trained Cyclists
Authors: Jones T. W. , Eddens L. , Kupusarevic J. , Simoes D. C. M. , Furber M. J. W. , Van Someren K. A. , Howatson G.
Published: March 2022

This study examined whether the intensity of endurance stimuli modifies the adaptation in strength and endurance following concurrent training and whether the acute molecular response to concurrent exercise is affected by training status. Using a parallel group design, trained cyclists were randomized to either resistance exercise followed by moderate intensity continuous training (RES + MICT, n = 6), or resistance exercise followed by work matched high intensity interval training (RES + HIIT, n = 7), across an 8 weeks training programme. A single RES + MICT or RES + HIIT exercise stimulus was completed 1 week before and within 5 days of completing the training programme, to assess phosphorylation of protein kinases of the mTOR and AMPK signaling pathways. There were no main effects of time or group on the phosphorylation of protein kinases in response to concurrent exercise stimulus pre- and post-training intervention (p > 0.05). Main effects of time were observed for all maximal strength exercises; back-squat, split-squat, and calf-raise (p < 0.001), with all improving post intervention. A time × group interaction was present for V̇O2peak, with the RES + MICT group displaying a preferential response to that of the RES + HIIT group (p = 0.010). No time nor group effects were observed for 5 min time trial performance, power at 2 and 4 mmol L−1 (p > 0.05). Whilst preliminary data due to limited sample size the intensity of endurance activity had no effect on performance outcomes, following concurrent training. Further, the acute molecular response to a concurrent exercise stimulus was comparable before and after the training intervention, suggesting that training status had no effect on the molecular responses assessed.
Morpho-Physiological, Yield, and Transgenerational Seed Germination Responses of Soybean to Temperature
Authors: Alsajri Firas Ahmed , Wijewardana Chathurika , Bheemanahalli Raju , Irby J. Trenton , Krutz Jason , Golden Bobby , Reddy Vangimalla R. , Reddy K. Raja
Published: March 2022

Temperature is the primary factor affecting the morpho-physiological, developmental, and yield attributes of soybean. Despite several temperature and soybean studies, functional relationships between temperature and soybean physiology and yield components are limited. An experiment was conducted to determine the optimum temperature for soybean gas exchange and yield components using indeterminate (Asgrow AG5332, AG) and determinate (Progeny P5333 RY, PR) growth habit cultivars. Plants grown outdoors were exposed to 5 day/night temperature treatments, 21/13, 25/17, 29/21, 33/25, and 37°C/29°C, from flowering to maturity using the sunlit plant growth chambers. Significant temperature and cultivar differences were recorded among all measured parameters. Gas exchange parameters declined with increasing temperature treatments during the mid-pod filling stage, and quadratic functions best described the response. The optimum temperature for soybean pod weight, number, and seed number was higher for AG than PR, indicating greater high-temperature tolerance. Soybean exposed to warmer parental temperature (37°C/29°C) during pod filling decreased significantly the transgenerational seed germination when incubated at 18, 28, and 38°C. Our findings suggest that the impact of temperature during soybean development is transferable. The warmer temperature has adverse transgenerational effects on seed germination ability. Thus, developing soybean genotypes tolerant to high temperatures will help growers to produce high-yielding and quality beans. The quantified temperature, soybean physiology, and yield components-dependent functional algorithms would be helpful to develop adaptation strategies to offset the impacts of extreme temperature events associated with future climate change.
Increasing Interspecific Difference of Alpine Herb Phenology on the Eastern Qinghai-Tibet Plateau
Authors: An Shuai , Chen Xiaoqiu , Shen Miaogen , Zhang Xiaoyang , Lang Weiguang , Liu Guohua
Published: March 2022

The phenology of alpine grassland on the Qinghai–Tibet Plateau (QTP) is critical to regional climate change through climate–vegetation feedback. Although many studies have examined QTP vegetation dynamics and their climate sensitivities, the interspecific difference in the phenology response to climate change between alpine species is poorly understood. Here, we used a 30-year (1989–2018) record of in situ phenological observation for five typical alpine herbs (Elymus nutans, Kobresia pygmaea, Plantago asiatica, Puccinellia tenuiflora, and Scirpus distigmaticus) and associated climatic records at Henan Station in the eastern QTP to examine the species-level difference in spring and autumn phenology and then quantify their climate sensitivities. Our results show that with significantly warming, the green-up dates of herbs were insignificantly shifted, while the brown-off dates in four out of the five herbs were significantly delayed. Meanwhile, the interspecific difference in brown-off dates significantly increased at a rate of 0.62 days/annual from 1989 to 2016, which was three times larger than that in green-up dates (0.20 days/annual). These diverse rates were attributed to the different climate controls on spring and autumn phenology. In particular, green-up dates in most herbs were sensitive to mean surface temperature, while brown-off dates were sensitive to the night surface temperature. Furthermore, brown-off dates are less sensitive to the warming in high ecological niche (with higher herb height and aboveground biomass) herbs than low niche herbs (with lower herb height and aboveground biomass). The increased phenology interspecific difference highlights the complex responses of herbs to future climate change even under the same alpine environment and indicates a potential alternation in the plants community of alpine QTP, which may further influence the regional climate–vegetation feedback.
Phosphorus Shapes Soil Microbial Community Composition and Network Properties During Grassland Expansion Into Shrubs in Tibetan Dry Valleys
Authors: Zhou Hanchang , Ma Anzhou , Zhou Xiaorong , Chen Xianke , Zhang Jiejie , Zhang Qinwei , Qi Xiangning , Liu Guohua , Zhuang Guoqiang
Published: March 2022

Alpine ecosystem stability and biodiversity of the Tibetan plateau are facing threat from dry valley vegetation uplift expansion, a process which is highly connected to variations in the soil microbial community and soil nutrients. However, the variation of microbial community properties and their relationship to soil nutrients have scarcely been explored in Tibetan dry valleys, which is a gap that hampers understanding the dry valley ecosystem’s response to vegetation change. In this study, we sampled grasslands (G), a grass-shrub transition area (T), and shrublands (S) along an uplift expansion gradient and investigated the link between microbial community properties and soil nutrients. The results showed that shrub degradation by grass expansion in Tibetan dry valley was accompanied by increasing relative phosphorus (P) limitation, which was the main driver for bacterial and fungal composition variation as it offered highest total effect on PC1 (0.38 and 0.63, respectively). Total phosphorus (TP) was in the center module of bacterial and fungal network under shrub soil and even acted as key nodes in fungal networks. During the replacement by grass, TP was gradually marginalized from both bacterial and fungal center network module and finally disappeared in networks, with ammonia and nitrate gradually appearing in the bacterial network. However, TC and total nitrogen (TN) were always present in the center modules of both fungal and bacterial network. These support that a TP variation-induced compositional and network functional shift in the microbial community was a potential reason for vegetation uplift expansion in Tibetan dry valley. This study highlighted the effect of TP on microbial community properties during dry valley vegetation uplift expansion and offered basic information on Tibetan alpine dry valley ecosystem’s response to climate change.
Metabolites Reprogramming and Na+/K+ Transportation Associated With Putrescine-Regulated White Clover Seed Germination and Seedling Tolerance to Salt Toxicity
Authors: Cheng Bizhen , Hassan Muhammad Jawad , Feng Guangyan , Zhao Junming , Liu Wei , Peng Yan , Li Zhou
Published: March 2022

Soil salinization is a serious challenge to many countries worldwide. Putrescine (Put) is related to the improvement of seed germination under salt stress, but molecular and metabolic mechanisms are still not fully understood. The objectives of this study were to determine the effect of seed soaking with Put on germination characteristics under salt stress induced by 100 mm sodium chloride (NaCl) and to further analyze subsequent stress tolerance associated with amylolysis, oxidative damage, sodium (Na+)/ potassium (K+) accumulation and transportation, and metabolic homeostasis in white clover (Trifolium repens cv. Haifa) seedlings. The results showed that seed soaking with Put significantly alleviated salt-induced decreases in the endogenous Put content, germination rate, germination vigor, germination index, Rl/SL, and fresh/dry weight of seedlings. Put application also significantly promoted starch metabolism through activating α-amylase and β-amylase activities under salt stress. The metabolomic analysis showed that seed soaking with Put significantly increased the accumulation of polyamines (Put and spermidine), amino acids (γ-aminobutyric acid, glutamate, alanine, proline, citrulline, etc.), organic acids (ketopentanic acid, malonic acid, malic acid, ketopentanic acid, cis-sinapinic acid, etc.), lipids and fatty acids (glycerol, stearic acid, linoleic acid, palmitic acid, etc.), sugars (levoglucosan, fucose, and anhydro-D-galactose), alcohols (myo-inositol, allo-inositol, hexadecanol, and threitol), and other metabolites (thymine, xanthine, adenine, guanine, and glycerol 1-phosphate, etc.) associated with enhanced tricarboxylic acid (TCA) cycle and γ-aminobutyric acid (GABA) shunt contributing to better osmotic adjustment, cell membrane stability, energy supply, and metabolic homeostasis when seeds germinated under salt stress. In addition, Put significantly up-regulated the AsSOS1, NHX6, SKOR, HKT1, and HKT8 expression levels which played critical roles in Na+ rejection and K+ retention resulting in higher K+/Na+ ratio during seed germination under salt stress. The Put-induced up-regulation of HAL2 transcription level could reduce the toxicity of 3′-phosphoadenosine-5′-phosphosulfate (PAPS) in cells. Current findings will provide an integrative understanding of Put-induced salt tolerance associated with amylolysis, metabolic regulation, and ionic homeostasis during seed germination.
Explicating How Skill Determines the Qualities of User-Avatar Bonds
Authors: Lynch Teresa , Matthews Nicholas L. , Gilbert Michael , Jones Stacey , Freiberger Nina
Published: March 2022

Many frameworks exist that explain how people interact with avatars. Our core argument is that the primary theoretical mechanisms of a user-avatar bond (i.e., UAB) rest with the way people engage avatars and, thereby, the broader digital environment. To understand and predict such engagement, we identify a person’s skill in handling/engaging the avatar in the digital environment as an ordering parameter (i.e., organizing predictor). Accordingly, we define skill as a person’s ability to enact their agency successfully to achieve desired states. To explain how skill orders experience, we ground our theorizing in ecological perception and systems theory. In our explication, we describe how stable action coupling (i.e., the linking of action inputs to perceived outcomes) enables a state of embeddedness (i.e., when the environment facilitates and constrains behaviors) in the digital environment. Then, we explain how embeddedness promotes motivational attunement (i.e., orienting of motivational systems) and what the digital environment affords to users at different levels of skill. Throughout, we consider how our theoretical scaffolding generates tractable contentions regarding how skill influences UABs.
Virtual Reality and Eye-Tracking Assessment, and Treatment of Unilateral Spatial Neglect: Systematic Review and Future Prospects
Authors: Kaiser Alexander Pilgaard , Villadsen Kristian Westergaard , Samani Afshin , Knoche Hendrik , Evald Lars
Published: March 2022

Unilateral spatial neglect (USN) is a disorder characterized by the failure to report, respond to, or orient toward the contralateral side of space to a brain lesion. Current assessment methods often fail to discover milder forms, cannot differentiate between unilateral spatial neglect subtypes and lack ecological validity. There is also a need for treatment methods that target subtypes. Immersive virtual reality (VR) systems in combination with eye-tracking (ET) have the potential to overcome these shortcomings, by providing more naturalistic environments and tasks, with sensitive and detailed measures. This systematic review examines the state of the art of research on these technologies as applied in the assessment and treatment of USN. As we found no studies that combined immersive VR and ET, we reviewed these approaches individually. The review of VR included seven articles, the ET review twelve. The reviews revealed promising results. (1) All included studies found significant group-level differences for several USN measures. In addition, several studies found asymmetric behavior in VR and ET tasks for patients who did not show signs of USN in conventional tests. Particularly promising features were multitasking in complex VR environments and detailed eye-movement analysis. (2) No VR and only a few ET studies attempted to differentiate USN subtypes, although the technologies appeared appropriate. One ET study grouped USN participants using individual heatmaps, and another differentiated between subtypes on drawing tasks. Regarding (3) ecological validity, although no studies tested the prognostic validity of their assessment methods, VR and ET studies utilized naturalistic tasks and stimuli reflecting everyday situations. Technological characteristics, such as the field of view and refresh rate of the head-mounted displays, could be improved, though, to improve ecological validity. We found (4) no studies that utilized VR or ET technologies for USN treatment up until the search date of the 26th of February 2020. In conclusion, VR-ET-based systems show great potential for USN assessment. VR-ET holds great promise for treatment, for example, by monitoring behavior and adapting and tailoring to the individual person’s needs and abilities. Future research should consider developing methods for individual subtypes and differential diagnostics to inform individual treatment programs.
Compliance With Epidemic Prevention Guidelines Among Wuhan Citizens Under the Stressors of the COVID-19 Pandemic: A Cross-Sectional Multidistrict Comparative Analysis
Authors: Wang Xuelian , Cai Yuwei
Published: March 2022

The current study aims to compare compliance with the COVID-19 prevention guidelines among citizens from 13 districts in Wuhan and to explore the influence of individual-level psychological factors and district-level factors on compliance. A total of 811 participants (52% females) from 13 districts in Wuhan were invited to complete surveys regarding demographics, psychosocial factors and compliance with epidemic prevention guidelines. Individual-level characteristics were combined with district-level measures to create multilevel predictive models of compliance with prevention guidelines, and used the Hierarchical Linear Model (HLM) to analyze the data. Findings revealed that there were significant differences in the compliance of citizens from 13 districts of Wuhan (F = 5.65, P < 0.001). Hierarchical linear model analysis revealed that the risk factors case growth rate, COVID-19-related perceived stress, anxiety, significantly negatively predicted compliance. Hope and conscientiousness significantly positively predicted compliance with prevention guidelines, and the negative predictive effect of anxiety disappeared. Overall, we found significant differences in compliance with prevention guidelines among different districts. Risk factors at the individual level have had a negative impact on individuals’ compliance with prevention guidelines, but this impact can be mitigated by the positive role of personal protective factors such as conscientiousness and hope.
Does Activating the Human Identity Improve Health-Related Behaviors During COVID-19?: A Social Identity Approach
Authors: Sparkman David J. , Kleive Kalei , Ngu Emerson
Published: March 2022

Taking a social identity approach to health behaviors, this research examines whether experimentally “activating” the human identity is an effective public-health strategy to curb the spread of COVID-19. Three goals of the research include examining: (1) whether the human identity can be situationally activated using an experimental manipulation, (2) whether activating the human identity causally increases behavioral intentions to protect the self and others from COVID-19, and (3) whether activating the human identity causally increases behaviors that help protect vulnerable communities from COVID-19. Across two preregistered experiments (total N = 675), results suggest (1) the manipulation of identification with humanity had a significant but small effect on participants’ psychological bond with all humanity (Cohen’s ds = 0.21 – 0.27), but not their concern for all humanity. However, the manipulation had (2) no causal effect on health-related behavioral intentions or (3) helping behaviors that reduce the spread of COVID-19. Limitations, future directions, and direct benefits of the research are discussed.
Exploring the Common Mechanisms of Motion-Based Visual Prediction
Authors: Hu Dan , Ison Matias , Johnston Alan
Published: March 2022

Human vision supports prediction for moving stimuli. Here we take an individual differences approach to investigate whether there could be a common processing rate for motion-based visual prediction across diverse motion phenomena. Motion Induced Spatial Conflict (MISC) refers to an incongruity arising from two edges of a combined stimulus, moving rigidly, but with different apparent speeds. This discrepancy induces an illusory jitter that has been attributed to conflict within a motion prediction mechanism. Its apparent frequency has been shown to correlate with the frequency of alpha oscillations in the brain. We asked what other psychophysical measures might correlate positively with MISC frequency. We measured the correlation between MISC jitter frequency and another three measures that might be linked to motion-based spatial prediction. We demonstrate that the illusory jitter frequency in MISC correlates significantly with the accrual rate of the Motion Induced Position Shift (MIPS) effect - the well-established observation that a carrier movement in a static envelope of a Gabor target leads to an apparent position shift of the envelope in the direction of motion. We did not observe significant correlations with the other two measures – the Adaptation Induced Spatial Shift accrual rate (AISS) and the Smooth Motion Threshold (SMT). These results suggest a shared perceptual rate between MISC and MIPS, implying a common periodic mechanism for motion-based visual prediction.
Study on Smart Home Interface Design Characteristics Considering the Influence of Age Difference: Focusing on Sliders
Authors: Yu Na , Ouyang Ziwei , Wang Hehe
Published: March 2022

Smart homes represent an effective approach to improve one’s quality of life. Developing user interfaces that are both comfortable and understandable can assist users, particularly the elderly, embrace smart home technologies. It’s critical to concentrate on the characteristics of smart home interface design and their impact on people of various ages. Since sliders are one of the most common components utilized in the smart home user interface, this article aimed to investigate the effects of slider design characteristics (e.g., button size, track color, and sliding orientation) on user performance and preference. Thirty-four participants were recruited for the experiment (16 for the young group, aged between 18 and 44 years; 18 for the middle-aged and elderly group, aged between 45 years and above). Our results revealed that both groups had shorter task completion time, less fixation time, and saccades on horizontal sliding orientation and larger buttons, which means better user performance. For the older group, the slider with color gradient track led to better user performance, while the track color only had less effect on the performance of the younger group. In terms of user preference, the results and performance of the older group were basically consistent, while the younger group had no significant difference in sliding orientation and track color.
Prevalence and Risk Factors of Burnout Among Female Oncologists From the Middle East and North Africa
Authors: Abusanad Atlal , Bensalem Assia , Shash Emad , Mula-Hussain Layth , Benbrahim Zineb , Khatib Sami , Abdelhafiz Nafisa , Ansari Jawaher , Jradi Hoda , Alkattan Khaled , Jazieh Abdul Rahman
Published: March 2022

Background

Burnout (BO) is a recognized challenge among the oncology workforce. It affects both genders with a higher frequency among women. This study examined the factors contributing to the development of burnout among female oncologists from the Middle East and North Africa (MENA).

Methods

An online cross-sectional survey was distributed to oncology professionals from different countries in the MENA region. The validated Maslach Burnout Inventory (MBI) of emotional exhaustion (EE), Depersonalization (DE), and Personal Achievement (PA) plus questions about demography/work-related factors and attitudes toward oncology were included. Data were analyzed to measure BO prevalence and related factors.

Results

Between 10 February and 15 March 2020, 545 responses were submitted by female oncologists. The responses pre-dated the COVID-19 pandemic emergence in the region. BO prevalence was 71% among female professionals. Women aged <44 years represented 85% of the cohort. Sixty-two percent were married, 52% with children and one-third practiced a hobby. Two-thirds worked in medical oncology, worked for <10 years and 35% worked in academia. The majority (73%) spent >25% on administrative work daily. Nearly half of the respondents (49%) expressed a recurring thought of quitting oncology and 70% had no burnout support or education. Inability to deliver optimal care was reported as distressing for career development in 82%. Factors significantly influencing the BO risk were identified. Marital status, having children, academia and years in practice did not impact the risk of BO among female oncologists from MENA.

Conclusion

Female oncologists from the Middle East and North Africa (MENA) were found to have a high prevalence of BO. In this cohort, the majority of women oncology workers were young and in their early to mid-career stages. Burnout was linked to being younger, practicing in North African nations, having a heavy administrative load, and having persistent thoughts of quitting. Practicing a hobby and engaging in oncology communication, on the other hand, reduced the chance of BO. Burnout support and education, specifically for oncology women, is required.
The Effects of Behavioral Foundations and Business Strategy on Corporate Dividend Policy
Authors: Liao Wen-Ju , Lin Yu-En , Li Xin-Zhe , Chih Hsiang-Hsuan
Published: March 2022

This study analyzes the influence of behavioral foundation factors and corporate strategic behavior on the formulation of corporate dividend policy. We use the Logit model and the OLS model for estimating the empirical model. The year- and industry-fixed effects are controlled in the model. We consider the behavioral foundations in three dimensions-ambiguity aversions, risk aversion, and loss aversion. The results show firms with high ambiguity or high risk infrequently pay dividends but firms with loss-averse behavior tend to pay dividends. This paper also provides evidence that a firms’ business strategy influences its corporate dividend policy. Aggressive firms inhibit the payout of dividends. In additional tests, we find the results remain unchanged in those firms with high corporate governance or high growth opportunities.
A Comparison of Non-verbal Maternal Care of Male and Female Infants in India and the United Kingdom: The Parent-Infant Caregiving Touch Scale in Two Cultures
Authors: Hodsoll John , Pickles Andrew , Bozicevic Laura , Supraja Thirumalai Ananthanpillai , Hill Jonathan , Chandra Prabha S. , Sharp Helen
Published: March 2022

Differences in infant caregiving behavior between cultures have long been noted, although the quantified comparison of touch-based caregiving using uniform standardized methodology has been much more limited. The Parent-Infant Caregiving Touch scale (PICTS) was developed for this purpose and programming effects of early parental tactile stimulation (stroking) on infant hypothalamic-pituitary adrenal (HPA)-axis functioning (stress-response system), cardiovascular regulation and behavioral outcomes, similar to that reported in animals, have now been demonstrated. In order to inform future studies examining such programming effects in India, we first aimed to describe and examine, using parametric and non-parametric item-response methods, the item-response frequencies and characteristics of responses on the PICTS, and evidence for cross-cultural differential item functioning (DIF) in the United Kingdom (UK) and India. Second, in the context of a cultural favoring of male children in India, we also aimed to test the association between the sex of the infant and infant “stroking” in both cultural settings. The PICTS was administered at 8–12 weeks postpartum to mothers in two-cohort studies: The Wirral Child Health and Development Study, United Kingdom (n = 874) and the Bangalore Child Health and Development Study, India (n = 395). Mokken scale analysis, parametric item-response analysis, and structural equation modeling for categorical items were used. Items for two dimensions, one for stroking behavior and one for holding behavior, could be identified as meeting many of the criteria required for Mokken scales in the United Kingdom, only the stroking scale met these criteria in the sample from India. Thus, while a comparison between the two cultures was possible for the stroking construct, comparisons for the other non-verbal parenting constructs within PICTS were not. Analyses revealed higher rates of early stroking being reported for the United Kingdom than India, but no sex differences in rates in either country and no differential sex difference by culture. We conclude that PICTS items can be used reliably in both countries to conduct further research on the role of early tactile stimulation in shaping important child development outcomes.
The Temporal Modulation of Nocebo Hyperalgesia in a Model of Sustained Pain
Authors: Camerone Eleonora Maria , Battista Simone , Benedetti Fabrizio , Carlino Elisa , Sansone Lucia Grazia , Buzzatti Luca , Scafoglieri Aldo , Testa Marco
Published: March 2022

Background

The direction and the magnitude of verbal suggestions have been shown to be strong modulators of nocebo hyperalgesia, while little attention has been given to the role of their temporal content. Here, we investigate whether temporal suggestions modulate the timing of nocebo hyperalgesia in an experimental model of sustained pain.

Methods

Fifty-one healthy participants were allocated to one of three groups. Participants received an inert cream and were instructed that the agent had either hyperalgesic properties setting in after 5 (Nocebo 5, N5) or 30 (Nocebo 30, N30) minutes from cream application, or hydrating properties (No Expectation Group, NE). Pain was induced by the Cold Pressure Test (CPT) which was repeated before cream application (baseline) and after 10 (Test10) and 35 (Test35) minutes. Changes in pain tolerance and in HR at each test point in respect to baseline were compared between the three groups.

Results

Tolerance change at Test 10 (Δ10) was greater in N5 (MED = −36.8; IQR = 20.9) compared to NE (MED = −5.3; IQR = 22.4; p < 0.001) and N30 (MED = 0.0; IQR = 23.1; p < 0.001), showing that hyperalgesia was only present in the group that expected the effect of the cream to set in early. Tolerance change at Test 35 (Δ35) was greater in N5 (MED = −36.3; IQR = 35.3; p = 0.002) and in N30 (MED = −33.3; IQR = 34.8; p = 0.009) compared to NE, indicating delayed onset of hyperalgesia in N30, and sustained hyperalgesia in N5. No group differences were found for HR.

Conclusions

Our study demonstrated that temporal expectations shift nocebo response onset in a model of sustained pain.
Investigating Anxiety and Fear of COVID-19 as Predictors of Internet Addiction With the Mediating Role of Self-Compassion and Cognitive Emotion Regulation
Authors: Moniri Reihaneh , Pahlevani Nezhad Kimia , Lavasani Fahimeh Fathali
Published: March 2022

Background

In addition to many deaths due to the Coronavirus pandemic, many psychological issues and problems are affecting people's health. Including the constant anxiety and fear of infecting themselves and their families, COVID-19 has led to excessive spending of time in cyberspace and the Internet.

Methods

In this study, the role of fear and anxiety of COVID-19 in predicting Internet addiction among 1,008 students was investigated. The mediating role of the two components of self-compassion and cognitive emotion regulation has also been measured. Data collection was done online due to the outbreak of the disease and a modeling method was used to analyze the data.

Results

The results shows that anxiety and fear of COVID-19 has a positive and significant relationship with both Internet addiction (r = 0.32) and maladaptive cognitive emotion regulation strategies (r = 0.17), and it has a negative relationship with self-compassion (r = −0.25).

Conclusions

The findings suggest that self-compassion can play a protective role against internet addiction at the time of COVID-19 pandemic while maladaptive strategies for emotion regulation can be risk factors for anxiety and fear of the virus.
Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome
Authors: Vollert Jan , Wang Ruisheng , Regis Stephanie , Yetman Hailey , Lembo Anthony J. , Kaptchuk Ted J. , Cheng Vivian , Nee Judy , Iturrino Johanna , Loscalzo Joseph , Hall Kathryn T. , Silvester Jocelyn A.
Published: March 2022

Background

Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. One potential reason may be the use of composite outcomes, such as the IBS Symptom Severity Scale (IBS-SSS) which includes descriptive items related to pain frequency and pain intensity as well as bowel dysfunction and bloating. We investigated if different features of IBS pain have distinct genetic associations and if these may be moderated by sex hormones.

Participants and Setting

Adult outpatients with moderately severe IBS (>175 on IBS-SSS) enrolled in a clinical trial reported IBS-SSS at baseline and after 6 weeks of therapy.

Methods

Fixed effects modeling was used to test the effect of COMT rs4680 genotype to change in pain severity (rated 0-100) and pain frequency (defined as number of days with pain in the past 10 days) from baseline to week 6 with IBS treatment. Parallel exploratory genome-wide association studies (GWAS) were also performed to identify single nucleotide polymorphisms (SNPs) associated with change in pain severity or pain frequency across all participants.

Results

A total of 212 participants (74% female) were included. The COMT rs4680 met allele was associated with decreased pain severity over the course of the trial in gene dosage models [beta(SE) −5.9 (2.6), P = 0.028]. Exploratory GWAS for change in pain frequency identified 5 SNPs in close proximity on chromosome 18 near L3MBTL4 which reached genome-wide significance (all P < 5.0E-8). This effect was not mediated by changing estradiol levels. There was also a region of chromosome 7 with 24 SNPs of genome-wide suggestive significance for change in pain severity (all P < 1.0E-5).

Conclusions

Previously reported association between COMT rs4680 genotype and treatment response as measured by IBS-SSS is related to pain severity, but not pain frequency. We also identified new candidate genes associated with changes in IBS pain severity (SNX13) and pain frequency (L3MBTL4) in response to treatment. Further studies are needed to understand these associations and genetic determinants of different components of IBS-SSS. ClinicalTrials.gov, Identifier: NCT0280224.