bluuebunny/crossref_metadata_2025 huggingface dataset:
Covid 19 Infection in Patients with Rheumatic Immune-Mediated Diseases in a Single University Hospital. Matched Case-Control Study and Literature Review.
Authors: Martínez-López David , Ferraz-Amaro Ivan , Prieto-Peña Diana , Sánchez-Bilbao Lara , Herrero-Morant Alba , Alvarez-Reguera Carmen , Benavides-Villanueva Fabricio , Corrales-Selaya Cristina , Trigueros-Vázquez Martín , Gonzalez-Gay Miguel A. , Blanco Ricardo
Published: August 2022

Background: COVID19 may present different degrees of severity. Viral infections in patients with rheumatic inflammatory diseases (R-IMID) tend to present more severe disease. However, data comparing the severity of the disease between R-IMID and the general population are scarce.Objectives: To compare predisposing factors, clinical, serological features, and severity of COVID-19 infection in patients with and without R-IMID.Methods: Case-control study in a single University Hospital. We included all consecutive patients with a diagnosis of an R-IMID and COVID-19 infection up to March 31st, 2021. This cohort was compared with patients without R-IMID and not receiving immunosuppressive therapy matched for sex and age (± 5 years). Confirmed infection was defined if the patient had a positive nasopharyngeal swab for SARS-CoV-2. COVID-19 severity was divided into mild, moderate, severe and critical according to the United States National Institute of Health (NIH) COVID-19 guidelines.Results: We included 274 R-IMID patients (185 women/89 men), mean age 59.1± 18 years. More frequent R-IMID were: Axial spondyloarthritis/ Psoriatic arthritis (32.5%), Rheumatoid arthritis (28.8%), Polymyalgia Rheumatica (8%) and Systemic Lupus Erythematosus (8%). Hypertension and dyslipidemia were more frequent in patients with R-IMID. In the R-IMID group, dyspnea was more frequent. Although most of the cases were mild, critical cases and deaths were more frequent in R-IMID. When adjusted by comorbidities, no statistical differences were observed.Conclusion: R-IMID have a very similar clinical presentation when compared to the general population. There is a trend to an increased severity of the disease in patients with R-IMID.
Business As Usual Versus Climate-responsive, Optimised Crop Plans – Irrigated Agriculture in Australia in 2060
Authors: Lewis Andrew , Montgomery James , Lewis Max , Randall Marcus , Schiller Karin
Published: August 2022

Climate change is impacting people's lives, with food security being a major concern for the future of many countries. In this paper, production capacity of current crops in a case study area in Australia is evaluated under future climatic condition. The predictive methods, on which this work is based, have the advantage of being robust---they able to simultaneously consider many climate change models---giving greater confidence in determining what the future will hold in this regard. The results indicate business as usual, in terms of the quantity and types of crops that can be grown presently, will not be sustainable in the medium and long term future. Instead, modelling indicates that changes in production and land use to maximise revenue per megalitre of water will be needed to deliver climate-smart agriculture.
Influence of Phosphogypsum on The Performance of Wheat (Triticum Aestivum L.) and Properties of Sodic Soil of Alage, Central Rift Valley of Ethiopia
Authors: Hasana Haile , Beyene Sheleme , Kifilu Alemayehu
Published: August 2022

Aims
Effect of phosphogypsum (PG) level and its application method on the performance of wheat and the chemical properties of sodic soils.
Methods
The field experiment was arranged as a split-plot design with three replications. Two methods of PG application (band and broadcast) were allocated as the main plot, and five PG levels (0, 50, 100, 150, and 200% GR) were randomly assigned as subplots. The experiments were repeated on plots and pots that were used for growing haricot beans using the same treatments and design. After two successive harvestings, soil samples (0–20 cm) were collected from each plot to compare treatment effects and analyzed for chemical properties.
Results
Results revealed that PG levels significantly reduced soil pH, ESP, and exchangeable Na+, whereas exchangeable Ca, SO4 − 2, and available P were significantly increased compared with control in both methods of PG application. Grain and straw yields, P uptake, and protein contents were also significantly increased with increasing levels of PG. However, yields were significantly decreased when growing the crop on plots and pots previously used for haricot beans. Yield reduction during the second growing might be due to the reduction of available P in the soil solution. Soil chemical properties and wheat yield better under band PG application than broadcasted plots.
Conclusions
The study showed that the PG amendment offers twin benefits in reclaiming the sodic soil and providing P and SO4 − 2 for growing crops. Repeating the experiment using higher levels of PG and at other sites on sodic soil is recommended to draw sound conclusions.
Radiation dose escalation for local advanced nasopharyngeal carcinoma patients with locally and/or regionally residual lesions after standard chemoradiotherapy
Authors: Jin Ting , Liu Nan-fang , Jin Qi-Feng , Hua Yong-Hong , Chen Xiao-Zhong
Published: August 2022

Purpose
To assess the effectiveness and toxicity of radiation dose escalation in treating local advanced nasopharyngeal carcinoma patients (LA-NPCs) who have locally and/or regionally residual lesion(s) after standard treatment.
Methods and materials:
From November 2011 to November 2020, 259 LA-NPCs with residual local and/or regional lesion(s) after receiving induction chemotherapy followed by concurrent chemoradiotherapy (IC + CCRT) from our hospital were included. The total dose of primary radiotherapy (RT) was 68.1-74.25 Gy (median, 70.4 Gy). The boost doses were 4.0–18.0 Gy (median, 9 Gy), 1.8-2.0 Gy/fraction.
Results
Five-year local relapse-free survival (LRFS), regional relapse-free survival (RRFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), failure-free survival (FFS) and overall survival (OS) for all patients were 90.2%, 89.1%, 79.5%, 87.9%, 69.0%, 86.3%, respectively. LRRFS, DMFS, FFS, and OS in patients with age ≤ 65 versus > 65, plasma EBV-DNA ≤ 500 versus > 500, T1 − 2 versus T3 − 4, N0 − 1 versus N2 − 3, and stage III versus stage IV showed no statistically significant differences. The interval between primary RT and boost was not a prognostic factor for LRRFS, DMFS, FFS, and OS. Males had a lower 3-year FFS rate than females (72.9% vs. 83.7%, P = 0.024). LA-NPCs with locally and regionally residual lesion(s) had the worst 3-year DMFS and OS rates compared with locally or regionally residual lesion(s) (77.7% vs. 98.8% vs. 87.4%, P = 0.014; 75.9% vs. 94.5% vs. 82.4%, P = 0.002).
Conclusion
Boost radiation was an option for LA-NPCs with locally and/or regionally residual lesions after receiving IC + CCRT. It warrants further prospective study.
Left-Behind Experience, Sexual Practices and Reproductive Health: Results of a Large-Scale National Survey of University Students
Authors: Li Yiping , Cao Wenzhen , Hee Jiayi , Han Jiaqi , Colino Marla , Patel Avni , Tang Kun
Published: August 2022

Left-behind experience is a demographic issue caused by unbalanced distributions of social determinants that affect individuals’ wellbeing. While the number of adolescents with left-behind experiences has increased over the past decades, the understanding of the impacts of left-behind experiences on the sexual and reproductive health of Chinese adolescents is limited. To determine the associations between left-behind experience and sexual health, this study analyzed 54,485 responses in the 2022 China Family Planning Association National College Student Survey sponsored by the China Family Planning Association with descriptive analysis and multivariable regression modeling. Participants with left-behind experiences demonstrated a higher prevalence of sexually transmitted infections (OR: 2.11, 95% CI:1.78—2.49) and unintended pregnancies (OR: 1.51. 95%CI: 1.26—1.82) but a lower prevalence of reproductive health problems (OR: 0.95, 95% 0.91—0.99), induced abortion (OR: 0.5, 95% CI: 0.28—0.95), and contraception at their first sexual behavior (OR: 0.81, 95%CI: 0.72–0.9). The studying results indicate sexual health disparities between adolescents with left-behind experiences and their counterparts, suggesting that current sex education programs in China should be further implemented to promote adolescent sexual health and dimmish the gap of health inequities.
New management of surveillance in patients with baseline serrated polyps: a large single-center retrospective cohort study in China
Authors: Ye Xiangxi , Han Peiyi , Wu Zhijie , Cui Yun , Chen Yingxuan , Chen Chaofei , Gao Qinyan
Published: August 2022

Background: Serrated polyps (SP) is associated with an increased risk of colorectal cancer. Patients with SP history tend to have SP recurrence. However, the risk factors for metachronous polyps (MP) in those patients are not well established. Methods: Data of colonoscopy were retrospectively reviewed from October 2012 to October 2021. The pathology database, electronic medical records and telephone follow-up data were also observed. Results: A total of 906 patients were studied which consisted of 278 patients with MPs and 628 patients without. Multiplicity of polyps (OR 13.63;95% CI 8.80-21.75), older age (OR 5.71;95% CI 1.87-20.63), abdominal obesity (OR 2.46;95% CI 0.98-6.42), current smoker (OR 2.93;95% CI 1.15-7.83) and sedentary lifestyle (OR 1.41;95% CI 1.22-1.65) are significantly associated with the risk of MPs. Patients with baseline SP<10mm were more likely to develop higher or same risk-grade polyps (HSRGP) (P=0.0014). Patients with non-clinically significant SPs whether coexisted with adenoma or not developed HSRGPs while comparing to others (P<0.001).Conclusions: Total number of polyps, older age, sedentary behavior, abdominal obesity and smoking status contributed to the risk of MPs at surveillance colonoscopy. Patients with grade 1 SPs might require closer surveillance. SPs coexisting with conventional adenoma did not increase the risk of MPs but may increase the risk of developing HSRGPs.
An IoT and Cloud Enabled Smart Chair for Detection and Notification of Wrong Seating Posture
Authors: Kundaliya Brijesh , Patel Smit , Patel Jaanvi , Barot Parv , Hadia S. K.
Published: August 2022

Modern-day lifestyle is hugely dependent on the computers as most of the work is directly or indirectly controlled by them. Such machines are reducing the efforts of human beings and improving the human lifestyle by enhancing comfort in doing the work. This enhanced comfort however is making the humans inactive as they tend to sit in one place for many hours. The sitting posture plays a very important role in avoiding the injuries to spine and joints. It gets difficult for the person to know the correct posture while sitting on a chair. In the proposed work, a cloud-based IoT-enabled smart chair is proposed that continuously monitors the seating posture of a person and notifies the person about the wrong sitting position while simultaneously storing the data on the cloud. The database stored in the cloud helps medical doctors to analyze the root cause of the problem related to the spinal or joint. The proposed work equipped with sensors, microcontroller, and cloud-enabled technology offers seamless connectivity and notification thus making the system suitable for any kind of environment.
Gustave Roussy Immune score for predicting postoperative complications and non-cancer death in elderly patients with colon cancer
Authors: Tominaga Tetsuro , Nonaka Takashi , Oyama Shosaburo , Takamura Yuma , Hashimoto Shintaro , Shiraishi Toshio , Sawai Terumitsu , Nagayasu Takeshi
Published: August 2022

Purpose
Gustave Roussy Immune (GRIm) score is prognostic marker in various cancers. The aim of this study was to investigate the relationship between GRIm score and short- and long-term outcomes in elderly patients with colon cancer.
Methods
Patients aged ≥ 75 years who underwent colectomy between 2008 and 2019 were eligible in the study. Patients were divided into high GRIm (GRIm-H, score 1–3) and low GRIm (GRIm-L, score 0) groups.
Results
A total of 430 patients were enrolled (GRIm-H, n = 126; GRIm-L, n = 304). High GRIm score was an independent predictive factor for postoperative complications (odds ratio, 4.146; 95%CI, 2.536–6.777; p < 0.001). Median follow-up was 42 months (range, 1–160 months). Five-year relapse-free survival (GRIm-H, 79.3% vs. GRIm-L, 92.7%; p = 0.001), overall survival (76.0% vs. 92.2%, p = 0.001), and non-cancer-specific survival (84.7% vs. 94.6%, p = 0.003) were lower in the GRIm-H group. Multivariate analysis revealed high GRIm as an independent predictive factor for overall survival (hazard ratio, 2.875; 95%CI, 1.451–5.698; p = 0.002) and non-cancer-specific survival (hazard ratio, 3.650; 95%CI, 1.612–8.265; p = 0.001).
Conclusions
GRIm score is useful for predicting postoperative complications and non-cancer cause of death in elderly patients, and might be suitable as a surrogate marker for selecting candidates for surgery or perioperative treatment.
QGA-QGCNN:A model of Quantum Gate Circuit Neural Network optimized by Quantum Genetic Algorithm
Authors: Gong changqing , Zhu hongsheng , Gani Abdullah , Qi Han
Published: August 2022

Using global optimization algorithm to optimize the initial weights and thresholds of traditional neural network model can effectively address the problems of premature convergence and lower accuracy. However, the shortcomings such as slower convergence speed and poor local search ability still exist. In order to solve these problems, a neural network model QGA-QGCNN using a Quantum Genetic Algorithm (QGA) to optimize Quantum Gate Circuit Neural Network (QGCNN) is proposed in this paper. In QGA-QGCNN, the initial parameters of QGCNN are optimized for the strong global optimization ability and faster convergence speed by using a QGA. In the proposed model, the normalized results of the predicted sample attributes are transformed into quantum states as the input of the network, and the quantum rotation gate is used to rotate the phase and control the reversal of the target qubits. Finally, the output of the network is obtained by entanglement of multiple qubits in the quantum Controlled-NOT (CNOT) gate. When dealing with more complex problems, the QGCNN model based on quantum computing has specific parallel computing capabilities and can give full play to its ability to blur uncertain problems, thereby improving detection performance. We use the authoritative 10% KDD-CUP99 data set in the field of network intrusion detection to conduct simulation experiments on the proposed QGA-QGCNN model. Experimental results show that the proposed intrusion detection model has lower false alarm rate and significantly accuracy compared to conventional attack detection models. And GQCNN optimized by QGA also improves the convergence performance of the model.
Measurements of the Density and Viscosity of Heavy Oil and Water- in-Oil Emulsions over a Wide Temperature Range
Authors: Sagdeev Damir I. , Khairutdinov Vener F. , Farakhov Mansur , Alyaev Valeriy A. , Gumerov Farid M. , Zaripov Zufar I. , Minkin Vladimir S. , Abdulagatov Ilmutdin M.
Published: August 2022

Density and dynamic viscosity of extra viscous heavy crude oil and water-in-oil (W/O) suspensions based on Ashalchinskaya (Tatarstan, Russian Federation) oil have been measured as a function of temperature and concentration of water at atmospheric pressure. The measurements were made at temperatures from (293 to 463) for density and from (293 to 367) K for viscosity with various concentrations of water (from 0 to 30% volume fraction). Measurements were made using modified hydrostatic weighing for density and falling body techniques for viscosity. The combined expanded uncertainty of the density, viscosity, pressure, and temperature measurements at 0.95 confidence level with a coverage factor of k = 2 is estimated to be = 0.1 % and = 10 %, = .0 %, and = 0.02 K, respectively. The reliability and accuracy of the new experimental method and correct operation of the modified experimental apparatus was confirmed with measurements using different methods (pycnometric, capillary flow, commercial standard instruments, Brookfield rotational viscometer). The effect of temperature and concentration of water on the measured values of density and viscosity of W/O suspensions were studied. Using crude dry oil, the effective viscosities of several synthetic W/O emulsions are measured at atmospheric pressure using a commercial standard instrument, Brookfield rotational viscometer and falling body technique for different shear rates, temperatures and volume fractions of the dispersed phase. The various correlation equations for describing viscosity as a function of temperature and dispersed phase volume fraction is developed. A number of factors such as water content, shear rate, shear stress, and temperature and their effects on the density and dynamic viscosity of dry crude oil and W/O emulsions were assessed.
Selenium And Selenoproteins Implications In Breast Cancer Patients
Authors: Salaramoli Sanaz , Besharat Sima , razavi amir nader emami , joshaghani hamidreza
Published: August 2022

Background: Controversy surrounds the hypothetical relationship between Selenium levels and an increased risk of breast cancer. Since Selenium plays its role through various selenoproteins, including selenoprotein P and S, our study aimed to analyze Se, SelS, and SelP roles in breast cancer. Methods: our study considered 30 tumors and tumor margin tissues from breast cancer patients and blood serum from patients and control subjects. Selenium measurements were carried out using an atomic absorption spectrometer, and selenoproteins were measured by the ELISA method.Results: Selenium and Selenoprotein P and S have lower proportions in patients' serum. Also, SelP and SelS levels were lower in tumoral tissue. A NEGATIVE correlation between serum and tumor levels of SelS has existed, as well as tumor margin and tumoral tissue. Also, a NEGATIVE correlation between SelP concentrations in tumor margin and tumoral tissue was observed. The correlation between SelS and SelP levels in tumors was NEGATIVE, as well as their correlation in tumor margin tissues.Conclusion: Selenium and Selenoprotein P and S have lower proportions in patients' serum; thus, they are quickly emerging as fascinating diagnostic targets.
Circulating anti-müllerian hormone in a cohort-study of women with severe obesity with and without polycystic ovary syndrome and the effect of a one-year weight loss intervention
Authors: Kataoka Josefin , Larsson Ingrid , Lindgren Eva , Kindstrand Li Oskarson , Schmidt Johanna , Stener-Victorin Elisabet
Published: August 2022

Background
Women with polycystic ovary syndrome (PCOS) have high circulating anti-Müllerian hormone (AMH) levels which is correlated with antral follicle count and polycystic ovarian morphology and negatively correlated with body mass index (BMI). Moreover, diet-induced weight loss in women with PCOS and overweight or obesity, reduce or normalize AMH-levels. There is, however, no previous study investigating the circulating AMH levels in women with severe obesity and how a structured diet-induced weight loss program affects circulating AMH levels in these women. Therefore, this study aims to investigate circulating AMH levels in a population of women with severe obesity (BMI ≥ 35 kg/m2) with and without PCOS, as diagnosed by the NIH-criteria, and to investigate the effect of a one-year weight loss program with a very low-energy diet (VLED) on circulating levels of AMH.
Methods
In a prospective cohort-study, were 246 severely obese women screened for PCOS diagnosis with the NIH-criteria. Circulating AMH and anthropometry were measured at baseline and after a 12-month weight loss intervention with very low-energy diet (VLED).
Results
Mean BMI was 39.9 ± 4.7 (PCOS), 39.6 ± 4.3 (non-PCOS) P = 0.960. Circulating AMH was higher in women with PCOS (5.47 ± 4.89 µg/L) compared with non-PCOS (2.66 ± 3.71 µg/L) P < 0.001 and was positively correlated with circulating total testosterone in both groups. Next we performed ROC-analyses, and show that circulating AMH could not discriminate women with PCOS and severe obesity from non-PCOS women with severe obesity. Finally, a one-year weight reduction program does not affect circulating AMH levels despite significant weight loss neither in women with PCOS, nor without PCOS and severe obesity.
Conclusion
Women with severe obesity and PCOS have elevated levels of circulating AMH compared to women without the syndrome. AMH-levels could not discriminate women with PCOS from non-PCOS because of low sensitivity and specificity. Significant weight loss was not associated with changes in circulating AMH levels, neither in women with, nor without PCOS and severe obesity. These results imply that in women with severe obesity, a greater weight loss may be needed to improve reproductive features, independent of PCOS diagnosis.
Trial registration number:
Clinical trial.gov: NCT01319162.
Postoperative inpatient exercise facilitates recovery after laparoscopic surgery in colorectal cancer patients: a randomized controlled trial
Authors: Min Jihee , An Ki-yong , Park Hyuna , Cho Wonhee , Jung Hye Jeong , Chu Sang Hui , Cho Minsoo , Yang Seung Yoon , Jeon Justin Y. , Kim Nam Kyu
Published: August 2022

Purpose
The primary objective was to determine the efficacy of a postoperative exercise program on postsurgical recovery of stage I–III colorectal cancer patients.
Method
We randomly allocated participants to postoperative exercise or usual care (1:1 ratio). The postoperative exercise intervention consisted of 15 minutes of supervised exercise two times per day for the duration of their hospital stay. The primary outcome was the length of stay (LOS) at the tertiary care center. Secondary outcomes included patient-perceived readiness for hospital discharge, anthropometrics (e.g., muscle mass), and physical function (e.g., balance, strength).
Results
A total of 52 (83%) participants (mean [SD] age, 56.6 [8.9] years; 23 [44%] male) completed the trial. The median LOS was 6.0 days (interquartile range; IQR 5–7 days) in the exercise group and 6.5 days (IQR 6–7 days) in the usual-care group (P = 0.021). The exercise group met the targeted LOS 64% of the time, while 36% of the usual care group met the targeted LOS (colon cancer, 5 days; rectal cancer, 7 days). Participants in the exercise group felt greater readiness for discharge from the hospital than those in the usual care group (Adjusted group difference = 14.4; 95% CI, 6.2 to 22.6; P < 0.01). We observed a small but statistically significant increase in muscle mass in the exercise group compared to usual care (Adjusted group difference = 0.63 kg; 95% CI, 0.16 to 1.1; P = 0.03).
Conclusion
Postsurgical inpatient exercise may promote faster recovery and discharge after curative colorectal cancer surgery.
Motivational factors influencing readiness to use youth friendly services among secondary school students in East Belesa district, using the Theory of Planned Behavior, 2022
Authors: Tsegaw Menen , Kassie Ayenew , Alemnew Wallelign
Published: August 2022

Background: Youth refers to people aged between 15 and 24 years. The reproductive health of youth has become a major public health concern. The utilization of youth friendly services is low among Ethiopian school youths. Intention is the best predictor of behavior. However, there is no study done on the area which assesses the intention of the school youths to use youth friendly services. Therefore, this study is aimed to assess intention to use youth friendly services and associated factors among secondary school students in East Belesa.Objectives: This study was aimed to estimate the average intention to use youth friendly services and its factors among secondary school students in East Belesa district, using the Theory of Planned Behavior, 2022.Methods: An institution based cross-sectional study was conducted from May 23 to June 12, 2022 in East Belesa district. Stratified random sampling technique was used. Data was entered using EpiData version4.6 and analyzed using STATA version 14. Standardized β and R2 values were used to interpret effects and variability with intention to use youth friendly services respectively. Simple and Multiple linear regression analysis were performed. Statistical significance was declared at a p-value of <0.05 with 95% confidence interval.Results: A total of 511 respondents participated in the study giving a response rate of 99.8%. Around half of the participants were males (52.8%). The mean score of intention to use youth friendly services was 3.39±1.14. Direct perceived behavioral control (β = 0.25, 95%CI: 0.05, 0.45), subjective norm (β = 0.28: 95%CI: 0.09, 0.47), attitude (β = 0.20; CI: 0.03, 0.36), educated mothers (β = 1.65, 95%CI: 0.21, 3.09) and female sex (β = -1.77; 95% CI: -3.10, -0.44) were significant predictors of intention to use youth friendly services.Conclusion: the magnitude of intention to use youth friendly services was low. Perceived behavioral control, attitude, subjective norm, educated mothers and sex were the predictors of intention to use youth friendly services. The study informed that the theory of planned behavior could be applied to predict intention of youths to use youth friendly services.
Shortened ovarian stimulation duration may not affect oocyte developmental competence: a retrospective study
Authors: Yuan Lina , Han Ying , Lv Jiabei , Wang Xinyan , Zhang Yunshan , Zhang Yinfeng , Zhang Shuai , Xiao Nan , Luo Haining
Published: August 2022

Background: In recent years, an increasing number of scholars have begun to pay attention to the effect of gonadotropin (Gn) on the quality of oocytes and embryos. Some studies have focused on the relationship between Gn time and in vitro fertilization (IVF) outcomes. The aim of this study was to evaluate the effect of shortened ovarian stimulation duration on oocyte developmental competence during an IVF cycle.Methods: A total of 1049 women undergoing first IVF cycles between January 2019 and December 2021 were included in this retrospective cohort study. The populations were stratified according to ovarian reserve. Polycystic ovary syndrome (PCOS) diagnosed by the Rotterdam criteria and diminished ovarian reserve (DOR), defined by the Bologna criteria. Criteria for normal ovarian reserve (NOR) are AMH levels > 1.4 ng/ml and AFC 7~20. The women were further grouped according to the duration of ovarian stimulation. A total of 139 (26.4%) patients were in the NOR≤8 days group, 387 (73.6%) were in the NOR>8 days group, 82 (27.6%) were in the PCOS≤8 days group, 215 (72.4%) were in the PCOS>8 days group, 54 (23.9%) were in the DOR≤7 days group, and 172 (76.1%) were in the DOR>7 days group. Oocyte development-related factors including oocyte retrieval rate, oocyte maturation rate, normal fertilization rate and normal cleavage rate were analysed. A generalized linear model was used to explore the association between ovarian stimulation duration and oocyte developmental competence.Results: The oocyte retrieval rate, oocyte maturation rate, normal fertilization rate and normal cleavage rate were not affected by shortened ovarian stimulation duration in any of the ovarian reserve populations. Although there were differences in baseline characteristics and ovarian stimulation-related factors among the groups, the results remained robust after we adjusted for these potential confounding factors using generalized linear model analysis.Conclusions: We did not find that a shortened duration of ovarian stimulation impaired oocyte developmental competence in any population. Shortened stimulation duration is not predictive of suboptimal results.
Difficulties in the Treatment of Complications and Rehabilitation after COVID-19. A Clinical Case
Authors: Andreichenko S. A. , Slepukhina M. A. , Bychinin M. V. , Klypa T. V. , Atamanova M. A. , Shirinsky V. G. , Karapetyan G. E.
Published: August 2022

The severe course of the new coronavirus infection (COVID-19) is associated with multiple life-threatening complications that lead to delayed initiation of active rehabilitation and unfavorable long-term treatment outcomes. Tracheoesophageal fistula is one of these complications. The specific feature of this event in COVID-19 is delayed tissue regeneration which requires a non-standard approach to management of such patients.

The article presents a clinical case of a pregnant patient after a complicated severe course of COVID-19 with the development of tracheoesophageal fistula, sepsis, and weakness syndrome acquired in ICU. The combination of complications of the disease led to a prolonged (about five months) period of rehabilitation.

Modern standard components of intensive therapy of such patients including regular monitoring of endotracheal/tracheostomy tube cuff pressure, dynamic assessment of nutritional status and its correction, rational antimicrobial therapy, screening of psychiatric disorders and early rehabilitation, will minimize the number of both early and delayed complications of COVID-19.
Asymptotically matched quasi-circular inspiral and transition-to-plunge in the small mass ratio expansion
Authors: Compère Geoffrey , Küchler Lorenzo
Published: August 2022

In the small mass ratio expansion and on the equatorial plane, the two-body problem for point particles in general relativity admits a quasi-circular inspiral motion followed by a transition-to-plunge motion.
We first derive the equations governing the quasi-circular inspiral in the Kerr background at adiabatic, post-adiabatic and post-post-adiabatic orders in the slow-timescale expansion in terms of the self-force and we highlight the structure of the equations of motion at higher subleading orders. We derive in parallel the equations governing the transition-to-plunge motion to any subleading order, and demonstrate that they are governed by sourced linearized Painlevé transcendental equations of the first kind. The first ten perturbative orders do not require any further developments in self-force theory, as they are determined by the second-order self-force. We propose a scheme that matches the slow-timescale expansion of the inspiral with the transition-to-plunge motion to all perturbative orders in the overlapping region exterior to the last stable orbit where both expansions are valid. We explicitly verify the validity of the matching conditions for a large set of coefficients involved, on the one hand, in the adiabatic or post-adiabatic inspiral and, on the other hand, in the leading, subleading or higher subleading transition-to-plunge motion. This result is instrumental for deriving gravitational waveforms within the self-force formalism beyond the innermost stable circular orbit.
The Beauty in Art as a Gateway to the Appearance of the Truthfulness of Existence. "On Beauty and Being: Hans-Georg Gadamer’s and Virginia Woolf’s Hermeneutics of the Beautiful", by Małgorzata Hołda, Peter Lang GmbH, Berlin 2021, pp. 310 (rev.)
Authors: Rashelbach Hovav
Published: August 2022

The book develops the current hermeneutic discourse concerning the notions of beauty and Being. It includes a discussion of melancholic beauty and its interconnection with the act of art’s creation. According to M. Hołda, the writings of both authors demonstrate a treatment of beauty based on ancient Greek thought, especially from the times of Plato and Aristotle. Gadamer reaffirms the intimate relationship between beauty and Being, which is also revealed in Woolf’s literary work.

----------------------

Received: 08/04/2022. Reviewed: 13/05/2022. Accepted: 14/06/2022.
A instalação de sistema fotovoltaico e o problema de afundamento de tensão em uma indústria
Authors: Hermann Gabriel Edgar
Published: August 2022

Resumo: Diversos casos de problemas com energia em industrias são registrados diariamente no Brasil. Muitos desses, apenas são notados quando testes para obtenção de parâmetros elétricos são realizados ou quando uma máquina mais sensível às oscilações de tensão é integrada na indústria. Este artigo apresenta um estudo de caso em uma indústria de beneficiamento de isopor, que após a instalação de um sistema fotovoltaico foram percebidos problemas na rede interna de energia da indústria, causado por uma máquina da linha de produção. Neste caso, depois de estudos e medições foi observado um afundamento de tensão, proveniente dessa máquina. Sendo assim, foi realizada toda a parametrização da máquina, desde seu transformador de alimentação, e também se observou o problema por meio de equações matemáticas. Depois de identificado o problema teoricamente e na prática, soluções foram pautadas e posteriormente instauradas, mostrando resultados significativos, e levando a conclusões interessantes, mostrando que em alguns casos pode-se utilizar equipamentos que não são desenvolvidos para determinada função e mesmo assim, obter resultados positivos.
The Association of Latitude and Altitude with COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis
Authors: Tekin Aysun , Qamar Shahraz , Bansal Vikas , Surani Salim , Singh Romil , Sharma Mayank , LeMahieu Allison M. , Hanson Andrew C. , Schulte Phillip J. , Bogojevic Marija , Deo Neha , Sanghavi Devang K. , Cartin-Ceba Rodrigo , Jain Nitesh K. , Christie Amy B. , Sili Uluhan , Anderson Harry L. , Denson Joshua L. , Khanna Ashish K. , Zabolotskikh Igor Borisovich , La Nou Abigail T. , Akhter Murtaza , Mohan Surapaneni Krishna , Dodd Kenneth W. , Retford Lynn , Boman Karen , Kumar Vishakha K. , Walkey Allan J. , Gajic Ognjen , Domecq Juan Pablo , Kashyap Rahul
Published: August 2022

Background:

Better delineation of COVID-19 presentations in different climatological conditions might assist with prompt diagnosis and isolation of patients.

Objectives:

To study the association of latitude and altitude with COVID-19 symptomatology.

Methods:

This observational cohort study included 12267 adult COVID-19 patients hospitalized between 03/2020 and 01/2021 at 181 hospitals in 24 countries within the SCCM Discovery VIRUS: COVID-19 Registry. The outcome was symptoms at admission, categorized as respiratory, gastrointestinal, neurological, mucocutaneous, cardiovascular, and constitutional. Other symptoms were grouped as atypical. Multivariable regression modeling was performed, adjusting for baseline characteristics. Models were fitted using generalized estimating equations to account for the clustering.

Results:

The median age was 62 years, with 57% males. The median age and percentage of patients with comorbidities increased with higher latitude. Conversely, patients with comorbidities decreased with elevated altitudes. The most common symptoms were respiratory (80%), followed by constitutional (75%). Presentation with respiratory symptoms was not associated with the location. After adjustment, at lower latitudes (<30º), patients presented less commonly with gastrointestinal symptoms (p<.001, odds ratios for 15º, 25º, and 30º: 0.32, 0.81, and 0.98, respectively). Atypical symptoms were present in 21% of the patients and showed an association with altitude (p=.026, odds ratios for 75, 125, 400, and 600 meters above sea level: 0.44, 0.60, 0.84, and 0.77, respectively).

Conclusions:

We observed geographic variability in symptoms of COVID-19 patients. Respiratory symptoms were most common but were not associated with the location. Gastrointestinal symptoms were less frequent in lower latitudes. Atypical symptoms were associated with higher altitude.
A Technical process of phytoconstituents extraction using Hydrotropes: Green and Sustainable Approach
Authors: Tripathi Devika , Raman Sunil Kumar , Mishra Sangeeta , Sahoo Jagannath
Published: August 2022

Background:

The design of green and sustainable extraction methods of natural products is currently a prime topic in the multidisciplinary area of applied chemistry, biology, and technology, with the growing consumer demand for greener alternatives that do not involve any chemicals and industry concerns of sustainable, nontoxic extraction routes, the application of novel extraction technologies in the drug industry have been widely studied.
Hydrotrope has fewer toxic effects, is economically friendly, and is independent of pH. These compounds can enhance the bioavailability, solubility, dissolution, extraction yield, and purity of extracted phytoconstituents.

Conclusion:

The recent review illustrates the extensive references to the novel extraction of Phyto active compounds through hydrotrope and depicts the summary of updated extraction technologies. The technique is recent, simple, less expensive, and environmentally advantageous. Updated advanced extraction methods like ultrasound-assisted hydrotropic extraction (UAHE), microwave-assisted hydrotropic extraction (MAHE), and ultrasonic microwave-assisted hydrotropic extraction (UMAHE) have been considered a clean, green, and efficient alternatives to conventional extraction technologies. The active phytoconstituents extraction using hydrotrope with advanced extraction technologies has claimed to enhance the extraction yield up to 99% compared with the extraction involving organic solvent of such bioactive. Consequently, when carried out at a reduced temperature, hydrotropic extraction provided a higher extraction yield in a lesser time and maintained the purity of phytoconstituents.
Virology of SARS-CoV2
Authors: Sriram Anitha , Vasave Ravindra , Maji Indrani , Kumar Rahul , Kumar Khatri Dharmendra , Bala Singh Shashi , K. Mehra Neelesh , Kumar Singh Pankaj
Published: August 2022

The 2019-nCoV RNA genome is highly protected by its unique structure
equipped with mechanistic spike proteins on its surface. Its RNA genome contains
almost all 14 Orfs encoding for at least 27 proteins. An Orf is a part of genetic material
that can undergo translation and produce proteins. Four structural proteins (SPs) likely
spike (S), envelope (E), membrane (M), and nucleocapsid (N) are present in 2019-
nCoV and afford its structure. In this chapter, we have discussed in detail the virology
of 2019-nCoV including structural proteins (SPs), accessory proteins, non-structural
proteins (NSPs), genomic structure, and its components. The role of SPs, accessory
proteins, NSPs of 2019-nCoV is discussed and this review also explains, how the
interaction of 2019-nCoV occurs with that of hACE2. Additionally, topics such as
stabilization of virus-binding hotspots on hACE2 by 2019-nCoV, the role of thioldisulfide interchanges in the interplay between 'S' protein and hACE2, and the
similarity (in terms of amino acid sequence homology) (%) of 2019-nCoV with SARS-COV are discussed.
Damage Response Framework of COVID-19
Authors: Sriram Anitha , Medtiya Pravin , Mahajan Srushti , Maji Indrani , Kumar Rahul , Kumar Singh Pankaj
Published: August 2022

: Numerous infectious diseases caused by microorganisms that rarely cause
disease in natural, stable immunocompetent hosts emerged in the late 20th century. The
existence of these diseases demonstrates that current principles of pathogenicity and
virulence fail to account for the fact that microbial pathogenesis is influenced by both
the microorganism and the host. To overcome this impediment to studies on the host
and microorganism interactions, a new theoretical approach is addressed to understand
microbial pathogenesis known as DRF. COVID-19 is introduced as the third most
pathogenic strain in the human population, leading to the deaths of millions of people.
Therefore, it is necessary to understand the key pathogenic pathways at the molecular
level and identify the targets to develop the treatments strategies for COVID-19
infected populations. In this chapter, we have highlighted the different COVID-19
pathogenesis pathways along with targets and their role in the pathogenic conditions at
molecular levels. The DRF provides a lens to understand COVID-19 pathogenesis and
consider how potential therapies could alter the disease's outcome by focusing on
mechanisms of host damage, especially immune-mediated damage.
COVID-19 Vaccines and Vaccination
Authors: Sriram Anitha , Aalhate Mayur , Kumar Rahul , Kumar Khatri Dharmendra , Singh Shashi Bala , K. Mehra Neelesh , Kumar Singh Pankaj
Published: August 2022

Vaccines are life-saving immune biologicals. COVID-19 vaccines are
administered into the body to attain the acquired immunity against the disease-causing
virus 2019nCoV. The primary incentive of COVID-19 vaccines is to prevent
symptomatic illness as well as severe illness too. Getting vaccinated with COVID-19
vaccines will decrease the risk as well as the duration of 2019nCoV infection, i.e., a
decline in mortality, as proved in an experimental study conducted at the European
Institute of oncology by Italian scientists. Many vaccine candidates are in phase III and
phase IV trials with almost 95% efficacy in preventing symptomatic COVID-19
infections. According to official records from the national health agencies, 878.16
million doses of COVID-19 vaccines have been administered to the public as of April
16th, 2021, and 6.31 billion doses of COVID-19 vaccines have been delivered
worldwide as of October 2nd, 2021. This chapter reviews the number of vaccines
candidates’ ongoing, approved, and indispensable role played by the Indian
government in vaccine supply to the global market.
Internal Characteristics of Double-base Array
Authors: Kashyap Shubham , Mishra Kuber Nath , Sachdev Taranjeet , Tiwari Anil Kumar
Published: August 2022

The thermal applications of solar energy have gained momentum after the
revolution in the field of PV technology in recent decades. The worldwide quest to
harness the thermal component of solar energy, which constitutes the major part of
the incident, solar radiation incident globally, has led to the development of numerous
thermal devices and applications that harness and store or utilize the same with never
before seen efficiency. A few applications and devices are discussed here in this
chapter. The first part of the chapter presents a brief discussion of the solar pond and
its features along with thermal modeling of the system, followed by the thermal
modeling and discussions about solar cooling systems. The later part of the chapter
describes solar refrigerators and solar concentrators. The application and devices
discussed here are of prime importance in developing basic and advanced solar
thermal devices to harness solar thermal energy efficiently for human needs.
Thermal Modeling of Solar Stills
Authors: Singh Desh Bandhu , Tiwari G.N.
Published: August 2022

The design, analysis and modeling of solar energy-based water purifiers,
commonly known as a solar still, which is based on the greenhouse effect, is the
requirement of time as there is a scarcity of freshwater throughout the globe. The
technology of purifying dirty water using solar energy is a promising solution for
simplifying contemporary water scarcity as this technology does not create any bad
effect on the surroundings, unlike conventional water purification technology, which
creates a lot of polluting elements and ultimately has become problematic for the
environment. Most solar energy-based water purifiers are self-sustainable, and they
can be installed in remote locations where sunlight and source of impure water are
available in abundance. This solar energy-based technology of water purification
should perform better in hilly locations as the intensity of light is higher than the
intensity of light in fields. The current chapter deals with the thermal modeling of
different types of passive and active solar stills, including solar stills loaded with
water-based nanofluids, followed by their energy and exergy analyses.
Application and Development in Solar Stills
Authors: Thakur Vikas Kumar , Gaur M.K. , Tiwari G.N. , Sagar M.K.
Published: August 2022

One-third of the Earth is covered by seawater, yet there is a constant lack
of water in many places. A total of 97% of the water is present in the sea as salt water,
and only 3% of water is potable, out of which only 1% of clean water reaches the
people. Therefore, a device is needed that can convert salt water into clean water.
Solar still is a sustainable device through which dirty and salt water can be converted
into clear water. Due to the low productivity of conventional solar still; it is not
popular in the market. Increasing the productivity of conventional solar still is a major
challenge for researchers. Researchers are continuously working on the performance
of solar still to increase its productivity. The modifications and designs made by
researchers in solar still over the last ten years are encapsulated in this chapter. Solar
still with PCM, nanoparticles, reflectors, collectors, external condenser, wick
materials, and different angles are studied, and applications of distilled water have
also been covered in this chapter.
Semi-Transparent Photovoltaic Thermal (SPVT) Modules and their Application
Authors: Tiwari Arvind
Published: August 2022

In this review, an attempt has been made for various applications of semitransparent
photovoltaic thermal (SPVT) modules used for PVT-CPC water air
collector, drying, space heating/cooling of the building, greenhouse integration for
agricultural production of vegetables, and power generation. It has been observed that
semi-transparent photovoltaic thermal (SPVT) modules are more efficient and
economical for many sectors and have more advantages than opaque photovoltaic
thermal modules. The brief details of each case have been discussed. Furthermore, a
greenhouse integrated semi-transparent photovoltaic thermal (GiSPVT) system has
been elaborated for vegetable growth with different packing factors.;
Case Study on Thermal and Drying Performance Index of Hybrid Solar Dryer with Evacuated Collector
Authors: Saxena Gaurav , Gaur M.K.
Published: August 2022

Solar drying is one of the oldest and most popular food preservation
methods that involve moisture removal by a complex heat and mass transfer
phenomenon. The process of the drying system is dependent on a number of operating
parameters. In the present chapter determination of thermal and drying performance
parameters is discussed. A hybrid solar drying system with the integration of an
evacuated water tube solar water heater is installed and tested for drying hygroscopic
leaf crops. The drying performance of the hybrid system is evaluated in terms of mass
reduction and its derived influence on moisture content and drying rate. The derived
parameters are compared with the corresponding evaluations under open sun drying.
The rise in greenhouse environment temperature and crop surface temperature at
hourly intervals as compared to the ambient condition were used as parameters for the
thermal performance of dryer. The average values of SMER were 60% lesser than
that of the simple PVT-hybrid system (without ETSC), but the drying performance
parameters of mass reduction, drying rate and mass shrinkage ratio provide favourable
results. The drying time was reduced by 3.5 and 2.5 hours, respectively, for the present
sample size of two crops as compared to the open sun drying.