bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the Performance of Outcome Prediction for Inpatients With Acute Myocardial Infarction Based on Embedding Representation Learned From Electronic Medical Records: Development and Validation Study
Authors: Huang Yanqun , Zheng Zhimin , Ma Moxuan , Xin Xin , Liu Honglei , Fei Xiaolu , Wei Lan , Chen Hui
Published: July 2022

Background

The widespread secondary use of electronic medical records (EMRs) promotes health care quality improvement. Representation learning that can automatically extract hidden information from EMR data has gained increasing attention.

Objective

We aimed to propose a patient representation with more feature associations and task-specific feature importance to improve the outcome prediction performance for inpatients with acute myocardial infarction (AMI).

Methods

Medical concepts, including patients’ age, gender, disease diagnoses, laboratory tests, structured radiological features, procedures, and medications, were first embedded into real-value vectors using the improved skip-gram algorithm, where concepts in the context windows were selected by feature association strengths measured by association rule confidence. Then, each patient was represented as the sum of the feature embeddings weighted by the task-specific feature importance, which was applied to facilitate predictive model prediction from global and local perspectives. We finally applied the proposed patient representation into mortality risk prediction for 3010 and 1671 AMI inpatients from a public data set and a private data set, respectively, and compared it with several reference representation methods in terms of the area under the receiver operating characteristic curve (AUROC), area under the precision-recall curve (AUPRC), and F1-score.

Results

Compared with the reference methods, the proposed embedding-based representation showed consistently superior predictive performance on the 2 data sets, achieving mean AUROCs of 0.878 and 0.973, AUPRCs of 0.220 and 0.505, and F1-scores of 0.376 and 0.674 for the public and private data sets, respectively, while the greatest AUROCs, AUPRCs, and F1-scores among the reference methods were 0.847 and 0.939, 0.196 and 0.283, and 0.344 and 0.361 for the public and private data sets, respectively. Feature importance integrated in patient representation reflected features that were also critical in prediction tasks and clinical practice.

Conclusions

The introduction of feature associations and feature importance facilitated an effective patient representation and contributed to prediction performance improvement and model interpretation.
Store-and-Forward Images in Teledermatology: Narrative Literature Review (Preprint)
Authors: Jiang Simon W , Flynn Michael Seth , Kwock Jeffery T , Nicholas Matilda W
Published: July 2022

BACKGROUND

Store-and-forward (SAF) teledermatology uses electronically stored information, including patient photographs and demographic information, for clinical decision-making asynchronous to the patient encounter. The integration of SAF teledermatology into clinical practice has been increasing in recent years, especially during the COVID-19 pandemic. Despite this growth, data regarding the outcomes of SAF teledermatology are limited. A key distinction among current literature involves comparing the quality and utility of images obtained by patients and trained clinicians, as these metrics may vary by the clinical expertise of the photographer.

OBJECTIVE

This narrative literature review aimed to characterize the outcomes of SAF teledermatology through the lens of patient- versus clinician-initiated photography and highlight important future directions for and challenges of the field.

METHODS

A literature search of peer-reviewed research was performed between February and April 2021. Key search terms included patient-initiated, patient-submitted, clinician-initiated, clinician-submitted, store-and-forward, asynchronous, remote, image, photograph, and teledermatology. Only studies published after 2001 in English were included. In total, 47 studies were identified from the PubMed electronic database and Google Scholar after omitting duplicate articles.

RESULTS

Image quality and diagnostic concordance are generally lower and more variable with patient-submitted images, which may impact their decision-making utility. SAF teledermatology can improve the efficiency of and access to care when photographs are taken by either clinicians or patients. The clinical outcomes of clinician-submitted images are comparable to those of in-person visits in the few studies that have investigated these outcomes. Coinciding with the onset of the COVID-19 pandemic, asynchronous teledermatology helped minimize unnecessary in-person visits in the outpatient setting, as many uncomplicated conditions could be adequately managed remotely via images captured by patients and referring clinicians. For the inpatient setting, SAF teledermatology minimized unnecessary contact during dermatology consultations, although current studies are limited by the heterogeneity of their outcomes.

CONCLUSIONS

In general, photographs taken by trained clinicians are higher quality and have better and more relevant diagnostic and clinical outcomes. SAF teledermatology helped clinicians avoid unnecessary physical contact with patients in the outpatient and inpatient settings during the COVID-19 pandemic. Asynchronous teledermatology will likely play a greater role in the future as SAF images become integrated into synchronous teledermatology workflows. However, the obstacles summarized in this review should be addressed before its widespread implementation into clinical practice.
Association Between Internet Use and Physical Health, Mental Health, and Subjective Health in Middle-aged and Older Adults: Nationally Representative Cross-sectional Survey in China (Preprint)
Authors: Wen Wen , Zhang Yaru , Shi Wenjie , Li Jiajia
Published: July 2022

BACKGROUND

Internet use is an important means of accessing health-related information. Identifying the associations between internet use and health outcomes could provide insight into strategies for improving public health among middle-aged and older adults (45 years and up).

OBJECTIVE

This study aimed to examine the relationship between internet use and health outcomes in middle-aged and older adults.

METHODS

Data were obtained from the 2018 China Health and Retirement Longitudinal Study. Physical, mental, and subjective health were assessed using the Activities of Daily Living (ADL) Scale, the 10-item Center for Epidemiologic Studies Depression Scale, and the 3-level Self-Rated Health Scale, respectively. The chi-square test and rank sum test were used to explore whether internet use was associated with health status. A multivariate logistic regression model was used to determine this association further after controlling for the confounding factors.

RESULTS

Overall, 13% (1752/13,474) of the participants used the internet. Regression analyses revealed that the prevalence of depression (odds ratio [OR] 0.59, 95% CI 0.52-0.68; P<.001), negative self-rated health (OR 0.68, 95% CI 0.61-0.76; P<.001), and difficulty with ADL (OR 0.48, 95% CI 0.39-0.60; P<.001) in the participating middle-aged and older adult was lower in those using the internet than nonusers. After controlling for confounding factors, internet use was found to be negatively associated with difficulty with ADL (urban: OR 0.44, 95% CI 0.32-0.61; P<.001 vs rural: OR 0.55, 95% CI 0.41-0.75; P<.001), depression (urban: OR 0.69, 95% CI 0.57-0.84; P<.001 vs rural: OR 0.52, 95% CI: 0.43-0.63; P<.001), and self-rated health status (urban: OR 0.70, 95% CI 0.61-0.81; P<.001 vs rural: OR 0.67, 95% CI 0.57-0.78; P<.001) among middle-aged and older adults in both urban and rural areas.

CONCLUSIONS

Internet use had a positive effect on the physical and mental health of middle-aged and older adults who participated in this study. However, the internet usage rate remains low among older Chinese people. Therefore, the internet penetration rate should be a priority.
Determinants of Implementation of a Critical Care Registry in Asia: Lessons From a Qualitative Study (Preprint)
Authors: Tolppa Timo , Pari Vrindha , Pell Christopher , Aryal Diptesh , Hashmi Madiha , Shamal Ghalib Maryam , Tripathy Swagata , Tirupakuzhi Vijayaraghavan Bharath Kumar , Beane Abi , Dondorp Arjen M , Haniffa Rashan ,   Collaboration of Research Implementation and Training in Critical Care in Asia Investigato
Published: July 2022

BACKGROUND

The Collaboration for Research Implementation and Training in Critical Care in Asia (CCA) is implementing a critical care registry to capture real-time data to facilitate service evaluation, quality improvement. and clinical studies.

OBJECTIVE

To examine stakeholder perspectives on the determinants of implementation of the registry by examining technical, organizational, and social factors.

METHODS

This study is a qualitative phenomenological enquiry using semi-structured interviews with stakeholders involved in registry implementation in four South-Asian countries. The conceptual model of diffusion, dissemination, and sustainability of innovations in health service delivery guided interviews and analysis. Interviews were coded using the Rapid Identification of Themes from Audio recordings procedure and were analyzed based on the constant comparison approach.

RESULTS

Thirty-two stakeholders were interviewed. Analysis of stakeholder accounts identified three key themes; innovation-system fit; influence of champions and access to resources and expertise. Determinants of implementation included data sharing, research experience, system resilience, communication and networks, and relative advantage and adaptability.

CONCLUSIONS

The implementation of the registry has been possible due to efforts to increase innovation-system fit and influence of motivated champions with the support offered by access to resources and expertise. Risk for sustainability is posed by reliance on individuals and priorities of other healthcare actors.

CLINICALTRIAL

Not applicable
Machine Learning for Predicting neurological outcomes After Cardiac Arrest: A Systematic Review (Preprint)
Authors: Sun Xiaoyu , Cui XuanXuan , Lu Zongqing , Yang Min
Published: July 2022

BACKGROUND

Cardiac arrest (CA) is still one of the most common causes of death in the world. However, CA patients survived in 45 to 70% of the patients suffering from hypoxic-ischemic encephalopathy after CA, which is manifested as severe neurological impairment and death, and the survival rate is also reduced. A severe poor prognosis will lead to patients' physical and psychological damage, also leading to a serious burden and impact on the patients' families and society as well as serious burden and impact on the patients' families and society.

OBJECTIVE

Early clinical prediction of cardiac arrest (CA) can be beneficial and challenging. With the development of machine learning (ML) and a series of promising models to predict neurological outcomes after cardiac arrest, this study systematically reviewed the prediction value of these models.

METHODS

PubMed, Embase, WanFang Data, and CNKI databases were electronically searched to retrieve all ML studies on predicting CA from January 2015 to February 2021. Two reviewers independently screened literature, extracted data, and assessed the risk of bias in included studies. The value of each model was evaluated based on the area under the receiver operating characteristic curve (AUROC), sensitivity, or specificity.

RESULTS

A total of 30 studies were eventually included. In terms of data sources, five kinds of research were based on the public database, and other studies retrospectively collected clinical data. A total of 52 models had been adopted, among which the most popular ML methods included logistic regression (n= 22), followed by random forest (n= 9). The most frequently used input features were age (n=30) and gender (n=30). Three studies compared the regression models with other ML models and the results presented that Machine learning shows no advantage over traditional algorithms.

CONCLUSIONS

The available evidence suggests that ML can be predicting cardiac arrest outcomes, but the current set of predictor models are primarily built on supervised learning and mostly used regression models built on retrospective data.

CLINICALTRIAL

The study protocol was registered and approved on the international prospective register of systematic reviews PROSPERO before the start of the study (reference number CRD42021247323).
VIRTUAL TARGET CONSTRUCTION FOR DISCOVERY OF HUMAN HISTAMINE H4 RECEPTOR LIGANDS EMPLOYING A STRUCTURE-BASED VIRTUAL SCREENING APPROACH
Authors: NUGRAHA GERRY , PRANOWO HARNO DWI , MUDASIR MUDASIR , ISTYASTONO ENADE PERDANA
Published: July 2022

Objective: This study aimed to construct a virtual target to be used in structure-based virtual screening (SBVS) campaigns to discover ligands for human histamine receptor H4 (hHRH4).
Methods: The virtual targets construction was initiated by hHRH4 homology modeling, followed by molecular docking of seliforant to the homolog model, and the virtual target candidate was constructed. The hHRH4 complexed to seliforant was subjected to molecular dynamics (MD) simulations in 100 ns. Finally, the pose with the least free energy of binding from the MD simulations was selected for further validation through re-docking simulations. All simulations were conducted by using the YASARA-Structure program package.
Results: This study resulted in one validated target for SBVS protocols development. All RMSD values in the internal validation in snapshot 519 molecular dynamics simulation results were less than 2 Å, and this hHRH4 homology model is valid as a virtual target in an SBVS protocol. Moreover, using the clusterization module on MD simulations analysis, ten different virtual targets were available for further utilization.
Conclusion: Virtual targets resulted from this study offer more possibilities to construct SBVS protocols to identify hHRH4 ligands. The validated virtual target and the ten different virtual targets resulted from clusterization can be accessed in the following GitHub repository: https://github.com/nugrahagerry/hHRH4.
DETERMINATION OF AURINTRICARBOXYLIC ACID (A VIRAL INHIBITOR) USING MIXED MICELLAR CLOUD POINT EXTRACTION PROCEDURES
Authors: DIMMITI RADHA KRIS , SHAIK AMEER KHAN , PULIPAKA SHYAMALA
Published: July 2022

Objective: Development of micelle mediated cloud point extraction (CPE) and preconcentration of aurintricarboxylic acid (ATCA) (a viral inhibitor).
Methods: The method is based on the ion-pair formation between ATCA and a cationic surfactant tetrabutylammonium bromide (TBAB), which is extracted into the Triton X-114 (TX-114, a non-ionic surfactant) at a pH 4.4. The effect of different important parameters like pH, the concentration of surfactants (TX-114 and TBAB), salt, temperature, and time for the extraction of ATCA was optimized.
Results: Extraction efficiency of 90.28 % for CPE of ATCA was obtained using mixed micelles of TX-114 and TBAB. The linear range and limits of detection for ATCA was found to be 8.44-84.47 µg ml-1 and 8.14 ng ml-1, respectively.
Conclusion: The suggested CPE method has been applied to the determination of ATCA in aqueous solutions.
MOLECULAR DOCKING STUDY OF THE MAJOR COMPOUNDS FROM GARCINIA ATROVIRIDIS ON HUMAN SGLT-2 PROTEIN TRANSPORT USING STRUCTURE-BASED DRUG DESIGN METHOD
Authors: KUSWANDI ASEP , RUSDIN AGUS , TARAWAN VITA M. , GOENAWAN HANNA , LESMANA RONNY , MUCHTARIDI MUCHTARIDI
Published: July 2022

Objective: The objective of this work was to study the molecular interactions of phytochemicals in Garcinia atroviridis with SGLT-2 protein transport.
Methods: Molecular docking simulation using Autodock 4.2 was performed to explore the binding affinity of phytochemicals in Garcinia atroviridis against SGLT-2 protein transport. The structure-based pharmacophore model was derived using LigandScout 4.4 Advanced to investigate the important chemical interactions of the ligands and protein target. The evaluation was conducted based on the free energy binding and visualization in silico.
Results: From this study, Myricetin is the most effective compound having similarity of interaction with the amino acid residue, 4 of 5 are hydrogen bond interactions between the amino acid; HIS80, ASN75, TRP291, and LYS321 amino acid interacted with the oxygen as the proton acceptor from benzenes of the Myricetin structure, in addition, Myricetin also has the lower binding energy and inhibition constant (-9.54 kcal/mol and 101.93 nM, respectively) as compared to other compounds.
Conclusion: Hence, Myricetin could become the potential compound as an antidiabetic agent in the future with good activity and lower side effects.
CIRCADIAN RHYTHMS REGULATED ASTHMA TREATMENT BY VIRTUE OF PULSATILE DRUG DELIVERY SYSTEM
Authors: KHAN SAHIL , MONIKA
Published: July 2022

Asthma, as we all know, is a disease that shows a high tendency of chronic inflammation in the airways, which associates with airflow obstruction. Lung function seems to be decreased in the case of people suffering from asthma. On reviewing many studies from the past, clear statements come out which also revealed that asthma is based on established circadian rhythm. Asthma is considered to be one of the diseases which affects majorly common in adult women than in men; according to numerous studies, 42 percent of persons with active asthma claimed that their asthma started before they were 16 y old. The pulsatile drug delivery system, an innovation in pharmaceutical technology, is generating huge attention these days and is alleged to be the most productive in the treatment of asthma as per many studies. Many pulsatile delivery system components, such as the osmotic system, capsular system, and single and multiple-unit system, are utilized to diagnose and treat diseases caused by biological rhythm disturbances. Various emerging diseases such as cardiovascular, peptic ulcer, asthma, peptic ulcer, diabetes mellitus, cancer, and hypercholesterolemia have been examined by fluctuation in biological rhythms and treated by a pulsatile drug delivery system. During this era, the pulsatile drug delivery system delivers the medicine at the right time duration, in the right place, and the right proportion and the effectiveness of pulsatile drug delivery on asthma have indeed been investigated in this article.
INVESTIGATING EFFECTS OF PERMEATION ENHANCERS ON PERCUTANEOUS ABSORPTION OF LOXAPINE SUCCINATE
Authors: SHARMA CHANDAN , THAKUR NISHANT , KAUR BHUPINDER , GOSWAMI MANISH
Published: July 2022

Objective: The objective of the present work is to explore and screen the potential of selected permeation enhancers in increasing the (Loxapine succinate) LX penetration in the presence of adhesives.
Methods: LX was utilized as a model drug for its possible delivery via the transdermal route. Urea (U)(5,7.5 and 10% w/v), oleic acid (OA) (0.1, 0.5 and 1% w/v), peppermint oil (PO) (0.3,0.5 and 1% w/v), dimethyl sulphoxide (DMSO) (2.5,5 and 7.5 % w/v), propylene glycol (PG) (5,7.5 and 10 % w/v) and ginger oil (GO) (0.3,0.5 and 1% w/v) were explored for their effects on permeation enhancement. Franz-type, six diffusion cell assembly was utilized for the permeation studies across excised pig ear skin section. Flux rate, permeation coefficient of LX and enhancement ratio obtained using different PEs were used as parameters for evaluating the best possible combination of adhesive along with PE for LX permeation.
Results: Results showed that flux of LX improved from 119 µg/cm2/h to 178.84±4.136µg/cm2/h with 10 % w/v U. 1% w/v OA, increased the flux up to 442.61 µg/cm2/h. Incorporation of 1 % w/v PO increased flux up to 505.55±6.195 µg/cm2/h with ER of 4.22. The use of 7.5 % w/v DMSO raised the flux value to 456.41±6.186 µg/cm2/h with ER of 3.81. The patches consisting of GO (1% w/v) provided flux 574.10±5.165 µg/cm2/h and ER up to 4.79. The use of 10 % w/v PG raised the flux value to 414.5±5.189 µg/cm2/h with ER of 3.45.
Conclusion: It can be concluded by the investigation done in the research that GO provides the maximum possible flux in comparison to other permeation enhancers.
A REVIEW ON ADVANCES IN THE DEVELOPMENT OF SPERMICIDES LOADED VAGINAL DRUG DELIVERY SYSTEM: STATE OF THE ART
Authors: ABDELLATIF MENNA M. , ELTABEEB MOAZ A. , EL-NABARAWI MOHAMED A. , H. TEAIMA MAHMOUD
Published: July 2022

Spermicides are bio-actives that might immobilize/kill the sperm in the vaginal tissues inducing contraception in the female genitalia. To inhibit sperm viability, the spermicidal drug might have to inhibit the penetration of sperm through the cervical tube of the uterus as well as attack sperm present in the vaginal walls. There are several classes of spermicidal agents, such as bactericides, sulfhydryl binding agents, natural compounds, and synthetic products. There are several classes of spermicidal agents that are widely reported. Spermicides could be available in different dosage forms as foams, gels, creams, films, sponges, and nanofibers. Available pharmaceutical spermicides showed particular importance for production on a large scale due to the continuous need for contraception. The upscaling of a process can be performed using a quality by design approach to ensure the achievement of the similarity principle between lab-scale and industrial scale. In addition, risk evaluation is performed to recognize all high-risk factors that can negatively affect the product to build the design space. Furthermore, the knowledge of the critical quality attributes enables the selection of the appropriate settings on a larger scale to establish a product of good quality and good packaging.
SIMULTANEOUS QUANTIFICATION OF ACETYLSALICYLIC ACID AND CAFFEINE IN TABLETS BY FIRST-ORDER DERIVATIVE SPECTROSCOPY
Authors: MEDINA-LOPEZ JOSE RAUL , GONZALEZ-SALAZAR OMAR ALEJANDRO , CONTRERAS-JIMENEZ JUAN MANUEL
Published: July 2022

Objective: To develop an apply a new and easy UV-derivative method for the simultaneous quantification of acetylsalicylic acid (ASA) and caffeine (CAF) in commercial tablets. Derivative spectroscopy is an analytical methodology used to identify drugs in a mixture of two or more compounds without use of toxic dissolvents that are involved in chromatographic determinations.
Methods: Standard solutions of ASA (40-120 µg/ml) and CAF (5-25 µg/ml) were prepared with 0.1 M phosphate buffer pH 7.4. The zero-order spectra were determined from 200-300 nm. The method was validated according to International Conference on Harmonization (ICH) guidelines. An USP Apparatus 2 at 75 rpm with 900 ml of 0.1 M phosphate buffer pH 7.4 was used. For each drug, common dissolution data as the amount of drug released at 60 min (Q60), mean dissolution time (MDT), dissolution efficiency (DE), t50% and t85% were calculated.
Results: ASA was identified at 245 nm and CAF at 295 nm in the first-derivative mode. The method was linear (R2>0.99, *P<0.05). The precision and accuracy of the method were within acceptable limits. Q60, MDT, DE, t50%, and t85% values for ASA were 102.09%, 8.18 min, 88.15%, 2.91 min, and 11.98 min, respectively. Same parameters for CAF were 99.17%, 5.21 min, 90.54%, 1.09 min, and 5.70 min, respectively.
Conclusion: The proposed UV-derivative method is rapid and simple and can be easily adopted to determine the in vitro release curves of ASA and CAF from commercial tablets. The method generates reliable information that can be compared with published data.
DEVELOPMENT OF GEL-LOADED BASED MICROSPONGES OF CLARITHROMYCIN FOR THE TREATMENT OF TOPICAL DELIVERY
Authors: DHIMAN SUNNY , SHARMA NISHANT , THAKUR REENA , KUMAR INDER , THAKUR BHUMIKA , SHARMA ANKITA , THAKUR VANDANA , KUMARI KIRAN
Published: July 2022

Objective: The purpose of the present study aims to design a novel drug delivery system containing clarithromycin microsponges and to prepare microsponge gel.
Methods: The microsponges were prepared by quasi-emulsion solvent diffusion method using polymer eudragit RS-100. All the formulated microsponges were subjected to various evaluation parameters such as production yield, encapsulation efficiency, particle size analysis, and in vitro drug release study.
Results: In vitro drug release of all the formulations was found to be 47.36% to 87.32%. Formulations F2, F3, and F4 show the best drug release from all formulations within 480 min. The optimized microsponge formulations F2, F3, and F4 were further formulated as gel formulations for topical delivery. Prepared gel was evaluated for physical parameters like pH, spreadability, viscosity, drug content, in vitro diffusion study, and stability study. All gel formulations showed drug release of 63.18±0.52%, 76.4±0.51%, and 72.93±0.42% from formulations GF1, GF2, and GF3, respectively, within 480 min. The microsponge gel formulation GF2 showed the controlled release of clarithromycin for 480 min, which was 76.4±0.51%. The stability study shows no significant changes in all parameters.
Conclusion: With the revealed results by different evaluation parameters, it is concluded that the microsponges drug delivery system has become a highly competitive and rapidly evolving technology and more and more research is carried out to optimize the cost-effectiveness and efficacy of the therapy.
An Analysis of the Trends of Educational Policy Research Applying New Institutionalism
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Young Sin
Published: July 2022

Objectives This study examined the educational policy research based on the theory of new institutionalism and analyzed the trend of educational policy research applying the new institutionalism perspective from 2013 to 2021 to provide the direction of future educational policy research. Methods For this purpose, 58 studies using the new institutionalism perspective were selected as the subjects of analysis through three stages of literature research method and the trends were analyzed by opening related research materials. In the first stage, the analysis criteria were selected by examining the preceding studies related to the trend of education policy research applying new institutionalism. In the second stage, the related papers were investigated with the keywords ‘new institutionalism’ and ‘education’, and then the educational policy research materials were classified according to the analysis criteria. In the third stage, each research was analyzed according to the analysis area and standards. Results As a result of the study, educational policy research applying the theory and concept of new institutionalism has been actively conducted so far, and there have been many studies using integrated analysis frameworks emphasizing interest in institutional change and the role of actors. In terms of research topics, 58 papers from 2013 to 2021 were conducted evenly in the whole of educational policy studies based on new institutionalism. In terms of research methods, educational policy research has been conducted mainly on literature research, and qualitative research has gradually increased since 2013, but the proportion of quantitative research and mixed research has been relatively low. Conclusions The new institutionalism theory can be a useful approach to analyze educational policy, and it can increase the explanation power of the theory if it is applied to the education policy research after highlighting the issues of the analysis theory by grasping the issues and limitations of the theory.
Multi-Level Analysis of Factors Influencing Teacher Efficacy
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Mi Suk , Lee Jae Duck
Published: July 2022

Objectives The purpose of this study was to analyze the level of teachers and schools for teacher efficacy using the muti-level analysis method. Methods In this study, elementary school data from the Korea Educational Development Institute's ‘School Education Status and Level Analysis Study 2014’ were used. A two-stage multi-level analysis was conducted on 250 school questionnaires and 6,060 teacher questionnaires in the data. Results First, In teacher background factors, it was found that position, homeroom teacher status, gender, educational background, and career had a positive effect on teacher efficacy. Second, In school background factors, it was found that the ratio of the budget for basic educational activities had a positive effect on teacher efficacy. Third, In teacher process factors, it was found that the degree of reflection of school education goals, the degree of participation in internal and external learning group of education, and spending time in class for teaching, the number of open classes, and preparing time for teaching had a positive effect on teacher efficiency. Fourth, in the school process factors, positive perceptions of fellow teachers, the degree of meetings for educational activities, the degree of cooperation with fellow teachers, and the degree of professional conversation with colleagues had a positive effect on teacher efficiency. However, it was found that the principal's interest in teacher participation had a negative effect. Conclusions These research results can provide implications for what efforts schools should make to improve teacher efficacy. Various efforts in schools will contribute to the improvement of teaching and changes in schools.
Analysis of Research Trends Related to Counseling for Foreign Students and Meta-analysis of Correlations between Variables Related to College Life Adaptation
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Hyun-jin
Published: July 2022

Objectives The purpose of this study is to analyze the research trends related to counseling for foreign students and to explore the effect size by performing a meta-analysis of correlations between college life adaptation and related variables. Methods In November 2021, a total of 53 studies were selected for counseling-related research on foreign students published in the registered journals and candidate journals of the National Research Foundation of Korea. Based on previous research, analysis criteria were established and analysis was conducted on year, nationality, research method, research topic, etc. Among them, meta analysis of cognition cognition, emotion, and relationship-related variables for 10 studies on college life adaptation of foreign students was conducted. Results First, the research on counseling for foreign students started in 2008, and the research on Chinese students was the most frequent with 35 (66.0%). Second, as for the research method, quantitative research was the largest with 36 (67.9%). Third, the most research topics were personality and adaptation with 31 (58.4%). Fourth, as a result of meta-analysis, a small effect size appeared in the emotional and relational variable group, but no effect size was found in the cognitive variable group. Conclusions Based on these results, directions for research related to counseling for international students, intervention methods in the counseling scene for international students, and implications for follow-up studies were presented.
The development and application of a parent education program about reading books activities for parents with young children
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung Seokyung , Kim Seunghee
Published: July 2022

Objectives This study developed and investigated the effects of a parent education program about reading books activities for parents with young children. Methods Researchers developed a parent education program about reading books activities for parents with young children according to a 5-step process. The effects of the program were observed from fifteen parents of S preschool(experimental group) and fifteen parents of H preschool(comparative group). The experimental group participated in the parent education program about reading books activities for parents with young children, and the parents of the comparative group read books to their children at home freely. The effectiveness verification of the program was conducted for eight weeks from the 19th of July to the 17th of September in 2021 using a contact or contact-free way. Results The parent education program about reading books activities for parents with young children was composed of the contents and teaching-learning methods for parents with young children to interact with their children effectively, to improve maternal efficacy, and to promote their children’s language development. The results of this study showed that the scores of the parents’ maternal efficacy, the interaction between parents and their young chidlren, and young children’s vocabulary were meaningfully increased. Conclusions This study provided the information about a parent education program toward increasing parents’ maternal efficacy, the interaction between parents and their young chidlren, and young children’s vocabulary by demonstrating the educational effects of a parent education program about reading books activities for parents with young children. It was significant that this study suggested an effective parent education program to promote young children’s development and increase parents’ maternal efficacy.
A Study on Lexical Fluency Perception of Korean Language Teachers Using Grounded Theory
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Han Hye Jung
Published: July 2022

Objectives The purpose of this study is to clarify the concept of lexical fluency and construct of lexical fluency and to explore the perception of lexical fluency of Korean language teachers. Methods The perception of lexical fluency and construct of lexical fluency was investigated targeting 10 Korean language teachers. Grounded theory was used for objective analysis, and Strauss & Corbin’s paradigm model was applied among various models of grounded theory. Results The constructs for the evaluation of lexical fluency that Korean language teachers thought were varied, and it was confirmed that they had difficulties in the process of evaluating lexical fluency. Causal conditions, contextual conditions, interventional conditions, and action/interaction were identified, and it was confirmed that Korean language teachers recognized the importance of clear evaluation of lexical fluency. Conclusions Based on the results of the study, it was identified that a study on lexical fluency is necessary to accurately evaluate learners’ vocabulary competence. It was also suggested that the constructs of lexical fluency and the hierarchy between constructs should be discussed
Influences of Mahathirism in Utusan Malaysia editorials on Mahathir’s policies during his premiership from 1981-2003
Authors: Taib Abdul Halim , Mohd Adnan Hamedi , Ahamad Shah Mohamed Ismail
Published: July 2022

This study examined editorials in one of Malaysia's Malay newspapers, the Utusan Malaysia, from 1981 to 1987, during Mahathir's premiership. The study specifically examined the influence of Mahathirism on Utusan Malaysia's editorials on government policies. The theoretical framework of Reese's hierarchy of influences served as the foundation for this study. This qualitative study utilised retrospective in-depth interviews with key personnel of Utusan Malaysia as its methodology to answer the research questions. This study found no compelling evidence of direct or overt influence of Mahathirism on the editorials. What the study discovered was the chief editor, Zainuddin Maidin (ZAM)'s enthusiasm for Mahathir's thinking and his conviction that this Prime Minister possessed the courage to carry out his promises of a modernised and prosperous Malaysia and a greater share of the economy for Malays. The editorials demonstrate that he shared Mahathir's concerns about how Malaysia should be developed and how the Malay agenda and increased economic representation for the Malay community should be accomplished. We find in the editorials, not verbatim echoes of Mahathir’s thoughts and ideas, but ZAM’s original thinking about Malaysian nationalism, the Malay agenda and the assertion of Malaysian sovereignty in the face of Western dominance. Many of these ideas are reflected in what is conveniently called Mahathirism. By personal choice ZAM became UMNO's (United Malays National Organization) official spokesman and the journalist, who through his own thinking and unique perspectives on government policies, emphasised Mahathir's political and economic objectives for Malaysia, as well as Mahathir's emphasis on the Malay agenda, as the intellectual basis for his pro-Mahathir editorials. Utusan editorials are primarily influenced by ZAM's thinking and his commitment to Mahathirism or aspects of it.
Physique brand identity persuasiveness in social media message content
Authors: Mohd Johan Mohd Remie , Md. Syed Md. Azalanshah , Adnan Hamedi
Published: July 2022

This study focuses on how Malaysian micro SMEs, in this case, food truck (FT) businesses, could digitally utilize social media as an effective branding tool for their products and services and create significant customer value to survive in the local competitive market. It is crucial for Malaysian SMEs (food truck, FT) operators to convince their customers through social media message content, specifically on what is being posted on their social media page. Thus, we examined the different aspects of persuasive message content taking place on social media. A qualitative approach using semi-structured interviews was employed to explore the SME food and beverage service industry. In addition, interviews were conducted with independent food truck founders and owners in Kuala Lumpur, Malaysia. This study yielded results that showed respondents' interest in physique brand identity persuasion in social media platforms. Creating an excellent physique brand identity persuasion recognized by its customers through social media has become an important activity for food truck (FT) owners to communicate their brand digitally.
Radio dan perkembangan konsep Melayu Islam Beraja di Brunei
Authors: Dahlan Siti Salwana Syarfa
Published: July 2022

Malay Islamic Monarchy (MIB) is a concept of philosophy that belongs to Brunei Darussalam, practiced by all levels of society whether in the state affairs or everyday life. MIB was officially proclaimed as a nation’s philosophy in 1984. MIB is defined as the national philosophy which holds three essential elements or integral components, Malay, Islam, and Monarchy. Hence, this study was conducted to identify the extent and how the concept of MIB in Brunei’s radio broadcasts is being disseminated from the perspectives of Bruneians. As a result, it is shown that the MIB values are there being implemented and disseminated to the society through radio broadcasts. The dissemination consists of various aspects that are aligned with MIB which are Malay values, Islamic values, monarchial and statehood aspects, knowledge enhancement, and kinship. Melayu Islam Beraja (MIB) merupakan satu konsep falsafah yang menjadi milik Negara Brunei Darussalam, diamalkan oleh semua lapisan masyarakat sama ada dalam urusan negara mahupun kehidupan seharian. MIB telah diisytiharkan secara rasmi sebagai falsafah negara pada tahun 1984. MIB ditakrifkan sebagai falsafah negara yang mengandungi tiga elemen penting atau komponen integral, Melayu, Islam dan Beraja. Justeru, kajian ini dijalankan untuk mengenal pasti sejauh mana dan bagaimana konsep MIB dalam siaran radio Brunei disebarkan dari perspektif rakyat Brunei. Hasilnya, menunjukkan nilai-nilai MIB yang ada di sana sedang dilaksanakan dan disebarkan kepada masyarakat melalui siaran radio. Penyebarannya terdiri daripada pelbagai aspek yang diselaraskan dengan MIB iaitu nilai-nilai Melayu, nilai-nilai Islam, aspek beraja dan kenegaraan, peningkatan ilmu, dan persaudaraan.
Terasing di bumi asing: Naratif rintihan warga pelarian
Authors: Ibrahim Mohd Nazri
Published: July 2022

Book review: Refugees in Malaysia: Voices of the Displaced oleh Azizah Hamzah & Mohd Yahya Mohd Ariffin (peny.), Nilai: Penerbit Universiti Sains Islam Malaysia, 2021, 195 pp (ISBN: 9789674408657)
Nikolai Gogol’s Unknown Book, 1834: Intention, Context, Reminiscences
Authors: Vinogradov Igor' A.
Published: July 2022

The research is devoted to one of the many creative ideas of Gogol in 1834. The textual analysis shows the unity of the two historical works of the writer, which were previously published as separate works. These manuscripts testify that Gogol's “Bibliography of the Middle Ages” and the course of medieval history written at the same time (of ten lectures) represent a special edition that was being prepared for publication (which remained unpublished for unknown reasons). For the first time, the reader got acquainted with the “Bibliography of the Middle Ages” and Gogol’s ten university lectures in 1896, but until that moment these materials, published separately, have not been comprehended as a single whole prepared for publication. The publication of the book, which did not take place in 1834, is put in connection with Gogol's then cooperation with the Minister of Public Education S.S. Uvarov. During this period, thanks to the minister, Gogol entered the department of general history of St. Petersburg University and published four articles in the ministerial journal. The article analyzes the content of Gogol's lecture course and its relation to his other works. The author of the article proposes a possible title for the untitled book, based on the surviving Gogol lecture program.
Alice no país dos paradoxos: experimentação matemática em sala de aula inclusiva
Authors: Flugseder Roberta Labres , Santos Suelen Assunção
Published: July 2022

Este artigo é um recorte da Dissertação de Mestrado intitulada “Resolução de Problemas do tipo Paradoxo: possibilidade de intervenção pedagógica inclusiva para o Ensino de Matemática”, apresentada junto ao Programa de Pós-Graduação em Ensino de Ciências Exatas da Universidade Federal do Rio Grande –FURG (2021/1). Pretende-se mostrar o processo de composição de ‘Problemas do tipo Paradoxo’ como possibilidade de intervenção pedagógica para o ensino de Matemática em salas de aulas inclusivas dos anos finais do Ensino Fundamental. Para tanto, apresenta a inclusão escolar sob o enfoque da normalidade em Foucault, percorre as ponderações de Deleuze acerca da noção de problema, de paradoxo e do sentido, e detalha todo o processo para a composição dos referidos problemas, que por sua vez, são fundamentados na experimentação de cunho deleuzeano. Como resultado, apresentam-se os ‘Problemas do tipo Paradoxo’ construídos a partir de fragmentos da história de Alice no país das maravilhas, de Lewis Carroll.
Educação matemática, educação ambiental e interdisciplinaridade: experiência da semana do meio ambiente do CODAI da UFRPE
Authors: Nunes de Farias Filho Everaldo , De Souza Barros Alexandre Luis
Published: July 2022

Este artigo tem por objetivorefletir sobre a relação entre Educação Matemática (EM) e Educação Ambiental (EA) numa perspectiva interdisciplinar na escola básica a partir da experiência da Semana do Meio Ambiente (SMA) do Colégio Agrícola Dom Agostinho Ikas da UFRPE (CODAI). Para isso, realizamos uma pesquisa bibliográfica para fazer uma reflexão sobre o papel da EM no currículo das escolas e sua articulação com as questões ambientais baseada em referenciais teóricos da literatura e discutimos sobre a experiência da articulação entre aEM e a EA durante a realização da SMA e do CODAI da UFRPE, a partir da análise de oito trabalhos acadêmicos produzidos e apresentados por trinta estudantes durante o evento. Os resultados mostraram que a vivência da SMA serviu de contexto para a interlocução entre a EM e a EA no currículo do ensino médio a partir da utilização de conhecimentos e técnicas da Estatística para reflexão das causas e consequências dos problemas ambientais atuais numa perspectiva crítica e interdisciplinar.
El impacto de los paradigmas históricos en el conocimiento científico de la medicina
Authors: A Lozano
Published: July 2022

El saber es el núcleo central de la vida universitaria, entendiendo por saber: “conocimientoprofundo en una ciencia que se adquiere mediante el estudio y el hacer”, en el caso de las cienciasmédicas es el conocimiento de los distintos aspectos de la vida, de los procesos de salud y enfermedad.Este conocimiento surge de aplicar el método científico para obtener principios y leyes queexplican y permiten comprender el fenómeno observado. Este análisis indefectiblemente estáinfluenciado por el momento histórico de la ciencia y como señala Ortega y Gasset “…Si no fuera tanbarroca la imagen deberíamos representar las generaciones no horizontalmente sino en vertical…, unosobre los hombros de los otros…, nos llevaría a percatarnos que el pasado no se ha ido sin más ni más,de que no estamos en el aire sino sobre sus hombros…”
Hipertrigliceridemia en pancreatitis aguda: reporte de tres casos con sus tratamientos
Authors: N Semrik , P Lucero , I Gutiérrez Magaldi
Published: July 2022

La pancreatitis aguda (PA) es un proceso inflamatorio, agudo y reversible del páncreas. Presenta múltiplesetiologías, entre ellas la hipertrigliceridemia como tercera causa más frecuente. Suele generar entre el 1 al14% de todos los casos de PA. El riesgo incrementa de manera directamente proporcional a los niveles detriglicéridos séricos cuando éstos superan los 500 mg dL.Es importante tener presente esta etiología ya que se asocia a un mal pronóstico.A continuación, se presentan tres casos clínicos, dos varones y una mujer, jóvenes entre 35 y 41 años deedad.Se narran las diferentes evoluciones y tratamientos utilizados, sus respuestas según el valor de triglicéridos,teniendo en cuenta que no existe un tratamiento estándar para el manejo de la enfermedad por su pocafrecuencia.
Asymptotic stability of rarefaction wave for a blood flow model
Authors: Wei Jing , Yao Huancheng , Zhu Changjiang
Published: July 2022

This paper is concerned with nonlinear stability of rarefaction wave to
the Cauchy problem for a blood flow model, which describes the motion of
blood through axi-symmetric compliant vessels. Inspired by the stability
analysis of classical $p$-system, we show the solution of this typical
model tends time-asymptotically toward the rarefaction wave under some
suitably small conditions and there are more difficulties in the proof
due to the appearance of strong nonlinear terms including second-order
derivative of $v$ with respect to the spatial variable $x$. The main
result is proved by employing the elementary $L^2$ energy methods.
This is the first result about nonlinear stability of some nontrivial
profiles (i.e., non-constant function patterns) for the blood flow
model.
Temporal Lobe Hemorrhage as a Complication of HSV Encephalitis, a Case Report
Authors: Rijal Ashes , Chaudhary Sharmila , SHAH SANGAM , Itani Asmita , Suryabanshi Anil , Thapa Sangharsha
Published: July 2022

Herpes simplex encephalitis (HSE) is the most common type of sporadic
encephalitis that inflicts high rates of morbidity and mortality.
Differentiating a progressing encephalitis syndrome from a lobar
hemorrhage as a complication presents a challenge and requires great
vigilance and insight on part of the treating physician.