bluuebunny/crossref_metadata_2025 huggingface dataset:
Smart Ports: Is SADC positioned for Transition?
Authors: Grimett Leticia A
Published: January 2024

Whereas international trade was previously the preserve of organised business, the digital revolution and the increased popularity of online purchases on the internet has meant that international trade is now easily accessible at an individual level. At both a domestic and international level, the Covid-19 crisis amplified the pressure placed on businesses and consumers to adopt digital technologies, and this has been catalytic in moving the public towards greater reliance on online transactions and a movement away from traditional purchasing practices. Increased global trade at an individual level has put greater pressure on global supply chains, with every link in the supply chain being called upon to perform more effectively and efficiently. Ports, as gates of entry into domestic markets and transshipment routes, have been under increased pressure to conform to the needs of the international trading community. Greater trading volumes have put ports at risk of higher levels of crime by international and domestic criminal syndicates. The changing environmental landscape has meant that ships are being transformed for compliance purposes. Increased concern about water quality and impacts on sensitive habitats has put additional pressure on port authorities. These pressures have led to the creation of smart ports, which are fully automated, taking advantage of the latest technologies, blockchain and artificial intelligence (AI), and state of the art monitoring software and processes, while adhering to and promoting compliance with both the latest environmental protocols and the United Nations (UN) 2030 Sustainable Development Goals (SDGs). In this contribution to the conference, the discussion centres on the challenges facing ports in the Southern African Development Community (SADC) region, in the light of the latest global developments. Smart ports and the drivers towards greater changes are discussed and analysed. Finally, the state of ports in the SADC region are evaluated in the light of the latest global developments in order to determine whether our ports are prepared to transition and changes that can be made to facilitate the process.
The rise of digitalisation and automation in the shipping industry and their impacts on training and system safety
Authors: MacKinnon Scott N , Weber Reto , Lundh Monica
Published: January 2024

The ubiquitous application of digitalisation and automation within the maritime shipping industry will create disruptions that will have profound effects on how work is performed in the industry. The practice of safe navigation will require an evolution and subsequent evolvement of how operators and technologies interact in a complex sociotechnical system if a better understanding of system safety is to be achieved. Predictions of how actors and agents in the same workspace will emerge. This paper focuses on the current levels of automation prevalent in the navigation sector, a futuristic prediction and foresight of challenges related to the emergence of technologies, automation and artificial intelligence, and the competencies required related to the training of future seafarers.
Challenges in International Convention on the Standards of Training, Certification and Watchkeeping Compliance: A case study of the South African Maritime Education and Training System
Authors: Nhleko Yamkela
Published: January 2024

Maritime education and training (MET) has been instrumental in the development of seafarers in South Africa and internationally. As a result, different MET systems are used to not only produce eligible maritime professionals but to ensure that they comply with the requirements of the International Convention on the Standards of Training, Certification and Watchkeeping (STCW) 1978, as amended in Manila. Some of the challenges in MET prove not to be exclusive but common to some maritime countries. As such, this study aims to explore South Africa’s unique approach to MET rather than the conventional approach of having higher education institutions dedicated specifically to maritime education and maritime training. This has created the need to analyse how the current MET system delivers training in compliance with the minimum standards of the convention. This paper therefore analyses how the STCW Convention and Code is embedded in the MET system in South Africa, and identifies the existing challenges in meeting the requirements of the convention, as well as identifying opportunities for improvement. The identification of challenges and opportunities is investigated by means of desktop research, reviewing existing literature, a document analyses on the academic and technical (vocational) framework, and a review of existing practice and benchmarking this against international practice standards (STCW). This paper proposes a framework that could contribute to the improvement of the current MET system in line with the requirements of the STCW 1978 as amended.
Emotional distress and quality of life in teachers during the pandemic
Authors: Vlad Valentin , Sandu Mihaela Luminița
Published: January 2024

The advent of the COVID-19 pandemic precipitated an unparalleled public health exigency globally. The enforced cessation of operations within educational edifices necessitated an expeditious shift from traditional pedagogy to a virtual educational paradigm. The initial and most palpable repercussion of the Coronavirus pandemic was observed in the alteration of human lifestyles. It drastically redefined interpersonal dynamics. Concurrently, there was a discernible transformation in individual attitudes towards self and others. Nevertheless, the exigencies of social isolation were found to be particularly arduous for individuals in solitude. Solitary inhabitants became acutely aware of their isolation, bereft of familial, social, and professional interactions. The imminent peril of the contagion engendered heightened vigilance towards personal health, compelling adherence to stringent regulations, notwithstanding the inherent sociability of humans. The intrinsic human yearning for social interaction, a component of self-actualization, was temporarily obviated. Concomitantly, the deleterious ramifications of social isolation and solitude began to surface. The eradication of customary leisure activities precipitated a void, punctuated by a collective inability to utilize time constructively. The impetus for selecting this subject matter was its contemporaneity and the desire to delve deeper into the tribulations engendered by the pandemic. Experiencing these tribulations from a student's perspective fostered a curiosity about their impact on educators. This discourse aims to elucidate the perturbations in quality of life and emotional distress, as well as the organizational stress effects during the pandemic epoch. Given the abrupt migration to online pedagogy necessitated by the pandemic, the study centers on pre-university educators, employing two digital questionnaires for data collection. The primary goal of this inquiry is to ascertain the correlation between emotional distress and various facets of life quality among pre-university pedagogues.
Analysis Of The Priority Handling Of Enveromental Drainage Construction Project At Dinas Pekerjaan Umum Dan Penataan Ruang Banjarbaru City
Authors: Achmad Rizani  , Aqli Mursadin
Published: January 2024

Flood is one of the main problems of big cities in Indonesia, including Banjarbaru City. This is often caused by the not supportive existing drainage capacity when compared to the increasing of crowded urban conditions and reduced green open space. Handling of drainage including rehabilitation is necessary so that drainage can function properly as expected. On the other hand the Banjarbaru City Government has a limited budget each year that can be disbursed for drainage handling. The purpose of this thesis is to analyze criteria and subcriteria that are important in determining the priority of drainage handling. The ANP (Analytic Network Process) method is analyzed using the criteria in the Minister of Public Works regulation number 12/PRT/M/2014 tentang Penyelenggaraan Sistem Drainase Perkotaan to determine priorities for handling environmental drainage with important criteria, namely aspects of inundation, economic loss, social disruption and government facilities, loss of disturbance. transportation, loss to residential areas, and loss of personal property rights. Based on these 6 criteria, priorities for handling environmental drainage in Banjarbaru City are determined. Furthermore, an analysis is carried out to evaluate the priority of the choices that occur. This study suggests to decision makers that ANP can be used to analyze drainage management priorities in Banjarbaru City. This research focuses on variables consisting of criteria or considerations which form the background for priorities in handling the environmental drainage system in Banjarbaru City. The primary data results obtained from the field survey were followed by analysis using the ANP method with data tabulation calculations and assisted by Super Decisions software to determine the priority scale for handling environmental drainage in Banjarbaru City. The treatment priority scale in the Super Decisions software, the data of which is based on field survey results and data tabulation calculations, found that there are several locations that have a large priority scale but treatment has not been carried out due to several factors that are not contained in Minister of Public Works Regulation 12/PRT/M/2014 concerning Implementation of Urban Drainage Systems.
Burden and Severity of Injuries at the Emergency Department of a Tertiary Hospital in Botswana- Princess Marina Hospital
Authors: Lobatse Boiki , Cox Megan , Motsumi Mpapho
Published: January 2024

Purpose: Injuries constitute a leading and growing cause of emergency department (ED) visits in sub-Saharan Africa. Characteristics of ED injury patients have been well-described in many parts of the world; however, data remain scarce throughout Africa, Botswana included. We aimed to describe in detail injury-related ED visits at an urban public referral hospital in Botswana.

Methodology: We conducted a retrospective chart review of all patients who presented to Princess Marina Hospital in Gaborone, Botswana, over a period of 4 randomly selected consecutive months. Demographic data, injury mechanism, type, severity and ED disposition were abstracted from the medical record into a Microsoft Access database designed for this study. Study variables were analyzed with summary statistics  for frequencies, percentages, means, medians and relationships using SPSS. Injury severity was calculated for each patient using the modified Kampala Trauma Score.

Results:  6715 ED visits occurred during the study period, and 1709 (25.5%) were injury related. Of these, 63.9% were male, 24.7% <14 years old, 6.7% age 14-19, 49.1% 20-40, and 19.5% >40. 35.9% were due to falls, 23.6% assault and 18.8% road traffic crashes. 40.5% isolated soft tissue injuries, 34.7% isolated extremity injuries, 9.4% multiple injuries and 5.3% head and neck injuries. Kampala Trauma Score II (KTS) was available for 76% of patients. 1.7% scored ≤6, 5.9% 7-8, and 92.4% 9-10. For patients with KTS ≤6, 18% died in the ED, 82% were admitted and 0% discharged home. For KTS 7-8, 0% died, 93.5% were admitted, 6.5% were discharged home.  For KTS II 9-10, 0% died, 26% were admitted, 74% were discharged home.

Unique Contribution to Theory, Practice and Policy: This study is among the first in Botswana to assess the burden of injuries using a validated injury severity scoring tool. Based on the study findings and applicability of the KTS II in our setting, we recommend that PMH ED incorporates and promotes a severity scoring system to help in planning and resource allocation. PMH ED receives many low acuity injuries therefore improving the availability of basic resources in local clinics may reduce overcrowding. Future studies should aim to involve multiple centers to get a true representation of injury burden in Botswana.
KARAKTERISTIK PRODUK DAN PROMOSI PENJUALAN TERHADAP TINGKAT PENJUALAN PRODUKACSESORIS SEPEDA MOTOR DI DEALER MAAR MOTOR KABUPATEN PIDIE JAYA
Authors: Mustaqim Ahlul , Isnaini Teuku , Zulfikar Zulfikar
Published: January 2024

Tujuan penelitian ini untuk mengetahui pengaruh karakteristik produk dan promosi penjualan terhadap tingkat penjualan acsesoris sepeda motor motor roda dua merek Honda pada Dealer Maar Motor Kabupaten Pidie Jaya. Responden dalam penelitian ini sebanyak 100 orang responden, data dikumpulkan melalui penyebaran kuesioner analisis data menggunakan regresi linier berganda. Hasil penellitian diperoleh ersamaan sebagai berikut Y = 4.194 + 0,416 X1+ 0,414 X2. Keputusan variabel karakteristik produk dan promosi penjualan berpengaruh secara signifikan terhadap tingkat penjualan. Uji korelasi hubungan antara variabel dependen dan independen yaitu masing-masing variabel karakteristik produk dan Promosi penjualan terhadap tingkat penjualan. Hasil analisis diperoleh indeks korelasi sebesar 80,7%, dapat dijelaskan bahwa antara variabel karakteristik produk dengan variabel promosi penjualan memiliki hubungan dengan tingkat penjualan. Pengaruh antara karakteristik produk dan promosi penjualan sebesar 65,2% berpengaruh terhadap tingkat penjualan, sehingga dapat disimpulkan naik turunnya tingkat penjualan dipengaruhi oleh faktor karakteristik produk dan promosi penjualan.Kata Kunci: Karakteristik produk, promosi penjualan dan tingkat penjualan
ANALISIS PENERAPAN STRATEGI INTEGRATED MARKETING DAN COMMUNICATION QUALITY TERHADAP TARGET PENJUALAN SEPEDA MOTOR RODA DUA MEREK HONDA PADA DEALER MAAR MOTOR PIDIE JAYA
Authors: Rizki Muhammad , Ismayli Ismayli , Isnaini Teuku
Published: January 2024

Info ArtikelABSTRAKPenelitian ini bertujuan untuk mengetahui strategi integrated marketing dan communication quality terhadap target penjualan sepeda motor roda dua merek Honda, sampel dalam penelitian ini 100 responden, data dikumpulkan dengan kuesioner, analisis data menggunakan regresi linier berganda. Hasil penelitian diperoleh nilai koefisien korelsi  (R) sebesar 74,9% dapat memberikan pengertian ada hubungan antara  integrated marketing  dan communication quality  dengan target penjualan.  Semakin  tingginya nilai yang diperoleh maka semakin erat pula hubungan antara variabel independen yaitu integrated marketing  dan communication quality  dengan variabel dependen, artinya semakin erat pula hubungan masing-masing variabel tersebut. Sedangkan koefisien diterminasi sebesar 63,1% dapat menjelaskan  pengertian, ada pengaruh yang signifikan antara  faktor integrated marketing  dan communication quality   terhadap target penjualan.  Pengaruh variabel integrated marketing  dan communication quality  sebesar  63,1% berpengaruh secara siginifikan terhadap target penjualan,  sedangkan selebihnya 36,9% dipengaruhi oleh faktor lain diluar dugaan persamaan ini. Kata Kunci: Integrated marketing, communication quality dan Terget Penjualan.Riwayat Artikel:Diterima: ……Direvisi: …....Dipublikasikan: …..Nomor DOI 10.47647/JEko.v2i2.590Cara Mensitasi :    Article InfoAbstract This study aims to determine the strategy of integrated marketing and communication quality to target sales of two-wheeled motorcycles brand Honda, the sample in this study was 100 respondents, data were collected by questionnaire, data analysis using multiple linear regression. The results of the study obtained a correlation coefficient (R) of 74.9% which can give an understanding that there is a relationship between integrated marketing and communication quality with sales targets. The higher the value obtained, the closer the relationship between the independent variables, namely integrated marketing and communication quality, and the dependent variable, meaning that the relationship between each of these variables is getting closer. While the termination coefficient of 63.1% can explain the meaning, there is a significant influence between integrated marketing and communication quality factors on sales targets. The influence of integrated marketing and communication quality variables of 63.1% has a significant effect on sales targets, while the remaining 36.9% is influenced by other factors beyond this equation. Keywords: Integrated marketing, communication quality and Sales Target.Article History :Received: ….Revised: ….Published: ….
ANALISIS FAKTOR DIFFERENSIASI PRODUK DAN MARKET SHARE TERHADAP TINGKAT PENJUALAN AKSESORIS WANITA DI KECAMATAN MEUREUDU KABUPATEN PIDIE JAYA
Authors: Fadlina Sarah , Yusnidar Cut , Ismayli Ismayli
Published: January 2024

Penelitian ini bertujuan untuk faktor differensiasi produk  dan market share  terhadap tingkat penjualan   Aksesoris wanita di Kecamatan Meureudu Kabupaten Pidie Jaya, sampel dalam penelitian ini sebanyak 100 orang, data dikumpulkan dengan cara penyebaran kuesioner, analisis data menggunakan regressi linier berganda. Hasil penelitian diperoleh nilai koefisien korelasi  (R) sebesar  86,3% dapat memberikan pengertian ada hubungan antara faktor differensiasi produk   dan faktor market share   dengan  tingkat penjualan,   artinya semakin erat pula hubungan antara differensiasi produk    dan market share   memiliki hubungan yang erat dengan kepuasan penguna jasa dengan nilai sebesar 86,3% dalam katagori hubungan yang kuat. Nilai koefisien diterminasi (R2) adalah  sebesar  84,7% dapat memberikan pengertian ada pengaruh yang signifikan antara  factor differensiasi produk  dan market share   dengan tingkat penjualan. Dengan demikian dapat dijelaskan bahwa semakin baiknya dilaksanakan dan ditingkatkan differensiasi produk    dan semakin meningkat market share  maka semakin berpengaruhnya terhadap tingkat penjaualan. Pengaruh differensiasi produk   dan market share sebesar 84,7% berpengaruh secara siginifikan (sig. 0,000) terhadap tingkat penjualan,  sedangkan selebihnya 15,3% dipengaruhi oleh faktor lain diluar dugaan persamaan ini. Kata Kunci: Differensiasi produk , market share dan tingkat penjualan
ANALISIS RASIO PROFITABILITAS UNTUK MENILAI NILAI PERUSAHAAN PROPERTY & REAL ESTATE YANG TERDAFTAR DI BEI
Authors: Husna Naziatul , Nazariah Nazariah , Ramjizah Ramjizah
Published: January 2024

Penelitian ini bertujuan Untuk mengetahui dan menganalisis pengaruh Net Profit Margin (NPM), Return On Asset (ROA), dan Return On Equity (ROE) secara simultan terhadap nilai perusahaan sektor property Real Estate yang di BEI dari awal pandemi Hingga New Normal (Periode 2019-2021). Populasi penelitian ini adalah seluruh perusahaan sektor property Real Estate yang di BEI dari awal pandemi Hingga New Normal yang terdaftar di BEI yang berjumlah 83 perusahaan dan sampel yang diambil sebanyak 30 perusahaan. Teknik pengumpulan data dalam penelitian ini adalah metode dokumentasi. Teknik analisis data menggunakan analisis regresi linear berganda menggunakan spss 21. Hasil penelitian menunjukkan bahwa Berdasarkan persamaan regresi terlihat bahwa koefisien untuk variabel ini bernilai negatif sebesar 0,053. Karena nila    (504 1.673) dan nilai signifikan (0,616 0,05). Berdasarkan persamaan regresi terlihat bahwa koefisien untuk variabel ini bernilai positif sebesar 062. Karena nila    (419 1.673) dan nilai signifikan (0,677 0,05), maka H1 diterima dan H0  ditolak. Berdasarkan persamaan regresi terlihat bahwa koefisien untuk variabel ini bernilai positif sebesar 306. Karena nilai  (2.613 1.673) dan nilai signifikan (012 0,05), maka H0 ditolak dan H3  diterima. hasil uji F menunjukkan nilai  ( 2.77 4.232 ) dan nilai signifikan (0.009 0.05 ). Maka hal tersebut menunjukkan bahwa variabel independen berpengaruh secara simultan terhadap variabel dependen. Kata Kunci: Net Profit Margin, Return On Asset, Return On Equity, Nilai   Perusahaan
ANALISIS PELAKSANAAN PENCATATAN KAS KECIL (PETTY CASH) PADA PT BARAJAYA (Perseroda)
Authors: Irayana Mela , Vonna Sari Maulida
Published: January 2024

Pengelolaan kas kecil (petty cash) penting untuk mendukung tugas pelaksanaan yg terdapat dalam perusahaan sehingga tidak perlu meminta dana keuangan setiap kali mengeluarkan dana yg relatif kecil. Umumnya perusahaan mengeluarkan dana yang relatif kecil untuk berbagai kepentingan operasional dari perusahaan, sehingga transaksi yang terjadi tidak terlalu rumit tapi harus tetap dilaksanakan secara baik dan teliti berdasarkan prosedur operasi pelaksanaan yang berlaku. Metode penelitian yg digunakan dalam penelitian ini adalah metode kualitatif menggunakan analisis deskriptif. Objek penelitian ini adalah pelaksanaan pencatatan kas kecil pada PT Barajaya (Perseroda). Tehnik analisis dilakukan dengan cara mengamati pelaksanaan pencatatan dan menghasilkan kesimpulan tentang pelaksanaan pencatatan kas kecil. Metode pengumpulan data yg digunakan adalah metode wawancara, dokumentasi, dan observasi. Pelaksanaan pencatatan kas kecil pada PT Barajaya (Perseroda) menerapkan metode atau sistem dana berubah (fluctuating fund system). Namun dalam Pelaksanaan kas kecil perusahaan saat ini masih dipegang oleh manajer keuangan, sehingga membuat tanggung jawab manajer keuangan perusahaan menjadi lebih banyak dan mempengaruhi pencatatan.Kata Kunci: Pelaksanaan, Prosedur, Kas Kecil.
PENGARUH SISTEM INFORMASI AKUNTANSI TERHADAP KUALITAS LAPORAN KEUANGAN PADA PT PLN NUSANTARA POWER
Authors: Tanjung Annisa Kifli , Fatmayanti Fatmayanti
Published: January 2024

Tujuan dari penelitian ialah mengidentifikasi pengaruh KLK berdasarkan perubahan SIA pada pada PT PLN Nusantara Power. Pendekatan yang diterapkan ialah analisis deskriptif dengan pemanfaatan data primer. Data pada penelitian ini diolah melalui SPSS 20. Analisis statistik yang diterapkan pada penelitian ini adalah uji analisis regresi linier sederhana, pengujian hipotesis dengan menggunakan uji t. Populasi penelitian berupa laporan keuangan pada PT PLN Nusantara Power. Sampel penelitian yang digunakan berwujud 31 responden pada PT PLN Nusantara Power upk Nagan Raya dengan pemerolehan sumber data melalui hasil pengisian kuesioner. Diketahui bahwa penerapan SIA berpengaruh pada KLK. Hasil penelitian menjelaskan penerapan sistem informasi akuntansi yang baik dan benar dapat memberikan peningkatan pada kualitas laporan keuangan.Kata Kunci: Kualitas Laporan Keuangan, Sistem Informasi Akuntansi.
STUDENTS’ PHONEMIC AWARENESS IN MASTERY ENGLISH VOWEL AND CONSONANT SOUNDS
Authors: Harahap Yunita Mutiara , Rahmawati Wiki Tedi
Published: January 2024

This research dealt with the students’ phonemic awareness in mastery English vowels and consonants sounds. The aim was to show activities carried out by the students to pronounce the English vowels and consonants sounds and to read as well as to write the sounds symbol in phonemic transcription. The subject in this research was the second semester students of English Education Study Program of a private university in Medan with total number of 15 students. Descriptive qualitative with observation was designed to implement this research. The subject of this research was observed thoroughly during the learning process. The result showed that the students were aware of phonemic in English sounds. They were able to understand the phonemic concept of English vowels and consonants sounds. They were able to pronounce and differentiate the phonemic transcription of English vowel and consonant sounds.
The Effect of Smokeless Tobacco on the Histopathology of Thyroid Gland in Albino Rats
Authors: Sana Javed Khoso  , Waheed Murad Dahri  , Saba Parveen  , Muzaffar Qayoom Khan Ghori  , Arslan Ali Vistro  , Fida Baloch
Published: January 2024

Objective: To investigate the effect of smokeless tobacco on the histopathology of the thyroid gland in albino rats.
Methodology: The experimental study was conducted at the Animal House of Sindh Agriculture University over a three-month duration from June to August 2018. Thirty healthy, non-pregnant female albino rats, aged 8-10 weeks and weighing 200-230 grams, were divided into three groups. The Control group received a standard diet, Experimental Group A was exposed to 5% smokeless tobacco, and Group B to 10%. Rats were housed under hygienic conditions. After the experiment, the rats were weighed, euthanized via cervical dislocation, and their thyroid glands were removed for detailed dissection. Tissues were preserved in 10% formaldehyde, processed for microscopic examination through paraffin embedding and sectioning (2-5 µm thick), and finally stained with Hematoxylin and Eosin (H&E) and trichrome stain.
Results: Significantly reduced weight was observed in albino rats from Group 2 and 3 compared to controls (p-value < 0.0001). In the control group (Group I), histological examination revealed a normal structure of thyroid follicles. In Group 2, stroma exhibited mild infiltration of chronic inflammatory cells, whereas Group 3 showed benign lesions with mild fibrosis.
Conclusion: In summary, smokeless tobacco has adverse effects on the weight of albino rats and may alter the normal histology of the thyroid gland. Further investigation into the effects on thyroid hormone levels and a study of the dose-dependent effects of various chemicals in smokeless tobacco on the thyroid gland are recommended.
Wound Healing Improvement by Polymer Surgical Suture Coated with Tannic Acid
Authors: Setiawati Agustina , Setyajati Flavia Domitila Erika , Saputra Bakti Wahyu , Skolastika Skolastika , Julianus Jeffry , Ratri Monica Cahyaning
Published: January 2024

A surgical suture is a vital medical device to uphold wounded tissue during surgery. However, the application to improve tissue healing must still be developed. This study offered to solve this problem by incorporating tannic acid (TA) into polydioxanone (PDS) sutures. The PDS suture was immersed in TA complexing with iron (III) solutions in pH 8.0 solution. The engineered suture was successful, as revealed by the OH peak of TA in FTIR spectra. Furthermore, it was confirmed by TA particle appearance under Scanning Electron Microscopy. Contact angle measurement showed better wettability in biological mimicking solutions, such as water, serum, and saline solution. Thereby, it improved in vitro wound healing activity. Moreover, our bioinformatics data showed that TA enhanced the wound healing process by addressing multiple targets in the early phase of inflammation. For instance, it induced platelets to reduce bleeding at the early wound healing stage, activated T cells at the inflammation stage, accelerated epidermis cell proliferation, and activated fibroblast as a key player in wound healing. Due to multiple wound healing targets, our suture system was expected to be emphasized in clinical applications.
HIGHLIGHTS

The engineered surgical suture was fabricated by modifying the surface of surgical suture with tannic acid (TA) through iron (III) complex formation in basic condition
The modified PDS suture had a high wettability degree of water, saline, and serum, representing the biological fluid, which was expected to have better biocompatibility
Based on bioinformatics analysis, TA revealed multiple targets to stop bleeding by activating platelet through FYN, CD4, and CD8 T cells, induced epithelial cells proliferation through Epidermal Growth Factor Receptor (EGFR), and activated many transcription and migration factors of fibroblast

GRAPHICAL ABSTRACT
Unified AI: A Revolutionary Solution for Content Generation
Authors: Mrs. Sonal S. Jogdand  , Yash A. Bhende  , Sahil V. Dumbre  , Parth M. Jadhav  , Kashish A. Degaonkar
Published: January 2024

In response to the relentless demand for creative and engaging content in the digital age, the Unified AI project emerges as a groundbreaking solution. Content creators across various domains, from videos and images to text, are constantly in search of innovative and efficient ways to captivate their audiences. Unified AI addresses this insatiable demand by introducing a comprehensive solution that empowers users to effortlessly generate audio, video, and images through state-of-the-art technologies.
Unified AI is a product of the growing need to streamline and democratize content creation. The project's primary goal is to make advanced technology accessible to a wider user base, thus empowering businesses, educators, artists, and individuals to create exceptional content. By bridging the gap between the increasing demands for automation and the limitations of existing content generation methods, Unified AI aims to revolutionize the content creation industry. The project seeks to provide an efficient, cost-effective, and user-centric solution to meet the diverse needs of content creators.
At its core, Unified AI serves as an intersection where cutting-edge technologies converge with the ever-evolving landscape of content creation. By leveraging state-of-the-art methods, the project not only meets the demands of the current digital era but also anticipates future trends and challenges. Through this initiative, the team behind Unified AI envisions a transformative impact on the content creation landscape, offering a versatile and adaptive solution for content creators in today's dynamic digital environment
Medicinal Herbal Plants Useful for Diabetes
Authors: Thorat Nikita Kishor  , Dr. Chandra Shekhar Sanap
Published: January 2024

The world is currently facing a diabetes epidemic. The World Health Organization (WHO) reported that the global prevalence of DM was 171 million in 2000 and will increase to approximately 366 million by 2030. However, the global prevalence of DM has already reached 346 million in 2010. About 1.6 million deaths are directly attributable to diabetes. Another 2.2 million deaths were caused by high blood sugar in 2012. The prevalence of diabetes has increased more rapidly in middle- and low-income countries. The exponentially increasing future high prevalence of DM accounts for most of the mortality and morbidity worldwide. Danger sign of diabetes and related diseases. India has been the source of human development and revolution since ancient times. We have a rich history and knowledge of the plants and animals used in the healing system. Plants have been used in medicine since the ancient Indian system of Ayurveda. Thus, we found that the diabetic drug system is highly dependent on the composition of synthetic drugs. In this review, we try to complete the traditional, phytochemical and pharmacological studies of medicinal plants. Natural products were considered the best choice because they are less harmful to the environment and other non-target organisms
Métodos para la investigación de la lingüística inglesa en publicaciones de revista de la Universidad de Panamá
Authors: González-Johnson Aracelis M. , González Vega Meibis , Cisneros Richard W. , Arrocha Eduardo
Published: January 2024

Este estudio examinó los métodos de investigación empleados en el campo de la lingüística inglesa en revistas académicas del área de Ciencias Sociales y/o Humanidades publicadas por la Universidad de Panamá entre 2018 y 2020. El principal criterio de elegibilidad fue la investigación original, no ensayos ni otros tipos de informes. Se utilizó un protocolo PRISMA para seleccionar la muestra resultando en 19 artículos de ocho revistas que fueron analizadas bajos los criterios de la Teoría Fundamentada. Se encontró que la mayoría de los estudios publicados (58%) utilizaron métodos cuantitativos, centrándose en estudios exploratorios y descriptivos. Las encuestas y cuestionarios fueron los instrumentos y/o técnicas más comúnmente empleadas en los estudios cuantitativos. En cambio, los métodos de investigación cualitativa utilizados en un 16% se caracterizaron por el uso de entrevistas grabadas y el análisis documental. Estos hallazgos recalcan la necesidad de diversidad metodológica en la investigación lingüística, y estos resultados pueden servir como punto de partida para futuros estudios que busquen ampliar y diversificar los métodos empleados en el campo de la lingüística inglesa.
Implementación de la clase invertida para el desarrollo de competencias científicas en maestros en formación a nivel superior
Authors: Tejeira Rodríguez Maricel
Published: January 2024

La investigación aborda el creciente interés en la didáctica universitaria, debido a los desafíos que enfrentan los docentes en la enseñanza-aprendizaje de las ciencias naturales. Se propone la implementación exitosa del modelo de la clase invertida (MCI) como una estrategia metodológica para el desarrollo de competencias científicas en docentes de primaria en formación en la Universidad de Panamá. La investigación fue experimental y exploratoria, utilizando dos instrumentos para evaluar la contribución del MCI al desarrollo de competencias científicas y la satisfacción de los estudiantes. Los resultados revelaron una diferencia significativa en las competencias científicas cognitivas y actitudinales antes y después de la implementación del MCI. Los estudiantes expresaron un alto grado de satisfacción al utilizar video-lecciones para el estudio individual en casa y luego llevar a cabo prácticas colaborativas en clase. Se concluye que los maestros en formación de la Universidad de Panamá lograron desarrollar competencias científicas mediante el MCI, lo que respalda su efectividad. Se recomienda continuar investigando en métodos disruptivos para la enseñanza de las ciencias naturales en Panamá. Este estudio destaca la importancia de adaptar estrategias innovadoras en la educación superior para mejorar la calidad de la enseñanza y el aprendizaje.
Estado y dinámica de la matrícula y la docencia en las comarcas indígenas de Panamá
Authors: Urriola Candanedo Gregorio
Published: January 2024

Esta investigación da a conocer el estado y la dinámica de las variables clave asociadas al sistema educativo en las comarcas indígenas (Ngäbe-Buglé, Kuna Yala y Emberá-Wounaan) de Panamá.   Es un estudio de carácter descriptivo que utiliza datos de matrícula y número de docentes, que aparecen publicados en fuentes oficiales, para un período de 10 años (2007 - 2016).  Se concluye con claridad que las comarcas presentan características particulares, tanto en nivel como en tendencias de rendimientos, con relación a los promedios nacionales.     Destaca, que aún persiste desventaja en cuanto al acceso de niñas al sistema, pues el alcance de la oferta educativa en el nivel preescolar es muy incipiente o casi nulo.   En cuanto a la relación de docentes y alumnos atendidos, en el caso de la Pre Media y Media se superan los promedios nacionales, en cuanto a la relación de alumnos por aulas de clase deja claras diferencias de hacinamiento para la comarca Ngäbe-Buglé a nivel primario, y baja matrícula en la comarca Emberá-Wounaan.  Se requiere un esfuerzo importante para asegurar una mejor cobertura, elevar la calidad y asegurar el éxito educativo de unas poblaciones postergadas por siglos de marginación y desidia, muy especialmente en la de mayor peso y crecimiento de población joven: la comarca Ngäbe-Buglé.
Importancia de articular la práctica pre-profesional, la investigación y el trabajo comunitario en la formación de futuros maestros
Authors: Borja Ramos Oswaldo Rafael , Castro Bungacho Iván Salomón
Published: January 2024

La presente investigación tiene por objetivo evidenciar la importancia de articular la práctica pre-profesional, la investigación y el servicio comunitario, como ejes prioritarios para la formación integral de maestros, procurando competencias para la planificación y ejecución de proyectos socioeducativos en el ámbito local o nacional, y con ello propender a un desarrollo social.  La metodología se basa en el enfoque cualitativo y cuantitativo, para lo cual se diseñó un instrumento tipo encuestas aplicado a una población de 156 estudiantes de diferentes semestres de la Facultad de Filosofía, Letras y Ciencias de la Educación. Entre los principales hallazgos del estudio se tiene que la mayoría de los estudiantes encuestados consideran importante el articular los procesos sustantivos de las instituciones educativas superiores, para su formación integral.  En conclusión, la articulación es fundamental para el proceso de enseñanza-aprendizaje y desarrollo de capacidades vivenciales de los estudiantes, definidas en competencias académicas y profesionales.
Impulsivity in migraine and in medication overuse headache: A literature review
Authors: Gonzaga Bruno Pissolati Mattos , Domingues Renan Barros
Published: January 2024

IntroductionPsychiatric symptoms and analgesic overuse may contribute to migraine chronification. Impulsivity is a common symptom in several psychiatric disorders that can potentiate substance overuse, including analgesics. Dopamine has been associated with migraine pathophysiology and impulsivity.ObjectiveThis review aims to assess the current knowledge about the potential association between migraine and impulsivity.MethodsPubMed and LILACS were queried using relevant descriptors related to migraine and impulsivity.ResultsFive articles were selected; however, none revealed a significant correlation between migraine and impulsivity. This lack of correlation was verified in different migraine subtypes (with or without aura, chronic, or episodic).ConclusionThe heterogeneity in patient grouping and diverse impulsivity assessment tools of the studies precluded definitive conclusions. The Barratt Impulsivity Scale (BIS-11) was the most frequently used tool. Given the paucity of data and the potential impact on migraine management, further studies are crucial to elucidate the potential association between migraine and impulsivity.
Aspirin and poetry: Did João Cabral de Melo Neto suffer from acetylsalicylic acid-overuse headache?
Authors: Cardoso Milena , Meneses Neto Pedro , Silva-Néto Raimundo Pereira
Published: January 2024

Introduction
João Cabral de Melo Neto is considered one of the most important Brazilian poets of all time. He suffered from severe headaches for the longest part of his life, being diagnosed with migraine. He took a significant amount of acetylsalicylic acid pills every day for many years.
Objective
The objective of this narrative review includes identifying how headache and its treatment influenced João Cabral de Melo Neto's poetry as well as analyzing the correlation between Melo Neto's migraine diagnosis and his documented overuse of aspirin and investigating the possibility of an acetylsalicylic acid-overuse headache diagnosis.
Methods
 The authors thoroughly read biographical books and interviews about the life of João Cabral de Melo Neto. They systematically documented all references to headaches and aspirin. Melo Neto's clinical case documented in his biography and interviews were juxtaposed with The International Classification of Headache Disorders (ICHD-3) diagnostic criteria for acetylsalicylic acid-overuse headache diagnosis.
Results
The word “aspirin” appears 8 times in 6 of Melo Neto’s poems. He compares it to the sun, attributing to it the capacity to refocus a "blurred body" (his state during a headache). The poet reported that took one aspirin pill every hour every day, for several years.
Conclusions 
Headache and the use of acetylsalicylic acid influenced João Cabral de Melo Neto’s poetry and life. He presented a risk behavior for developing medication overuse headache, specifically its subform: acetylsalicylic acid-overuse headache.
The Prevalence of migraine and associated factors among medical students in Ouagadougou (Burkina Faso)
Authors: Dabilgou Alfred Anselme , Dravé Alassane , Kyelem Julie Marie Adeline Wendlamita , Doukouré Mahamoudou Lamine , Napon Christian , Millogo Athanase , Karfo Kapouné , Kaboré Jean
Published: January 2024

Objective:

To determine the prevalence, clinical characteristics and impact of migraine among medical students in the city of Ouagadougou.

Methods:

This across-sectional study was carried out during a period of 6 months from August 2021 to January 2022. Participants were selected by stratified random sampling according to academic level. Hetero-administered questionnaire was administred to each student. Migraine was diagnosed according to the ICHD 3rd edition criteria and the MIDAS was used to assess the impact of migraine on students' quality of life.

Results:

Two hundred and twenty seven students were selected for this study. The prevalence of migraineurs was 31.8%. Their mean age was 22.20±2.67 years. There was female predominance among the migraineurs (73.9%). More than half of the migraineurs had a family history of headache disorders (53.6%). Migraine without aura was the most frequent subtype (59.4%). Visual aura was predominant (78.2%). Migraine was of moderate intensity in 60.8% of cases. Insomnia and/or lack of sleep was the most common trigger (73.7%) followed by stress and fatigue in 71% of cases. Migraine caused severe disability in 15.9% of migraineurs.

Conclusion:

There was a high prevalence of migraine among medical students in Burkina Faso. Stress and irregular sleep were the most common triggers factors.

Key words: prevalence, impact, migraine, medical student, Burkina Faso
Association of altered serum glucose and lipid profiles with headaches in young women: clinical, cross-sectional study
Authors: Zola Karen Valério , Da Silva Jóvyne Karollyna Kaleski Vicente , Lima Filho Jonas Bernardes , Ramos Bruna Ribeiro Andrade , Pereira Vinicius Coralino Dos Reis , Galli Nilva , Orsatti Claudio Lera
Published: January 2024

IntroductionHeadaches, including migraines and tension headaches, affect millions of people globally. Migraines are the most common neurological disorder, with around 14.4% of the world's population affected. It is suggested that dysregulation of biochemical markers and individual metabolic differences may contribute to headaches.ObjectiveWe evaluated the frequency of headaches or migraines with changes in lipid, glucose and vitamin D serum levels in young women.MethodsClinical, cross-sectional study with 139 young women, aged at least 18 years, based on the third edition of the International Classification of Headache Disorders (ICHD-3). The individuals were divided into two groups: one without headache and another with headache. Anthropometric analyzes (BMI, WC, BP and DBP) and blood samples were collected for analysis of vitamin D, glycemia and lipid profile.ResultsMean age was 22 (±4.6) years. We observed associations between headache and the following factors: high glucose levels (97 mg/dL, p=0.028), total cholesterol (180.4 mg/dL, p=0.002), HDL (44.2 mg/dL, p=0.017), and LDL (121.6 mg/dL, p=0.005). Longer duration of headache attacks was associated with increased levels of glucose (97.9 mg/dL, p=0.028), total cholesterol (186.8 mg/dL, p=0.05), diastolic blood pressure (74 mmHg, p=0.038), and BMI (24.6 kg/m2, p=0.024). High glucose levels were found to be directly related to the presence of migraine, particularly those with aura (105 mg/dL, p=0.034). However, there was no significant difference in vitamin D levels (p=0.640). ConclusionElevated levels of blood glucose and total plasma cholesterol and its fractions seems to be associated can increase with bouts of headache attacks, especially migraine, prolonging the duration of pain.
Migraine Preventive Treatment Failure: A Cross-Sectional Study in a Tertiary Center in Brazil
Authors: Oliveira Arão Belitardo , Nogueira Eduardo Almeida Guimarães , Peres Mario Fernando Prieto
Published: January 2024

BackgroundIn Brazil, there is a scarcity of evidence on migraine burden in patients who have experienced previous preventive treatment failure (PPTF). ObjectiveTo evaluate the associations between ≥ 3 PPTF and clinical, psychiatric, and medical history data.MethodsIn a retrospective, cross-sectional study, the medical records of migraine patients who first visited a tertiary specialized clinic were examined. We selected adults of both sexes aged ≥ 18 who attended their first appointment between March and July 2017. Ordinal logistic regression models estimated the associations between number of PPTF (no previous treatment, 1 PPTF, 2, and ≥ 3 PPTF) and chronic migraine, the number of diagnosis exams performed, abortive drugs classes used, and non-pharmacological treatments tried (all categorized as none, 1- 3, and ≥ 4),  and severe depression (PHQ-9 ≥ 15) and anxiety (GAD-7 ≥ 15), adjusted for sex, age, and years with disease.ResultsData from 440 patients (72.1 % female) with a mean (SD) age of 37.3 (13.0) years were analyzed. The frequency of no previous treatment was 37.7 % (166/440), while 31.8 % (140/440) showed ≥ 3 PPTF. In patients with ≥ 3 PPTF, 35.7 % (50/140) had episodic, and 64.3 % (90/140) had chronic migraine. Compared to no previous treatment, patients with ≥ 3 PPTF showed higher odds (95 % confidence interval) for chronic migraine [2.10 (1.47, 2.98)], ≥ 4 diagnosis exams [6.59 (3.38, 12.84)], ≥ 4 abortive drug classes [16.03 (9.53, 26.94)], ≥ 4 non-pharmacological treatments [5.91 (3.07,11.35)], and severe depression [1.75 (1.07, 2.88)] and anxiety [1.73 (1.05, 2.85)]. ConclusionPatients first visiting a headache specialist had a high frequency of non-response treatment associated with higher migraine burden in terms of chronification, psychiatric comorbidity, acute medication and non-pharmacological treatment inefficacy, and unnecessary exams.
Tourette’s Syndrome cervical dystonia induced occipital neuralgia remedied by peripheral nerve stimulation: A case report
Authors: Joseph Crystal , Parkash Anishinder , Gallagher John , Chitneni Ahish , Hirsh Kaveeshvar
Published: January 2024

BackgroundDystonia is uncommon in Tourette’s syndrome, and occipital neuralgia secondary to Tourette's dystonia is more rare, affecting quality of life. Occipital peripheral nerve stimulation (PNS) is an excellent alternative by being adjustable and minimally invasive. Our case demonstrates occipital PNS as an effective option for refractory Tourette’s dystonia.Case PresentationA thirty-four-year-old male with poorly controlled Tourette’s cervical dystonia presented with severe occipital neuralgia. Various medications were prescribed including propranolol and amitriptyline, and bilateral third-occipital nerve rhizotomies and occipital nerve blocks were trialed. Distal nerve blocks at the occipital protuberance were most effective. Therefore, an occipital PNS trial was done, and a PNS was implanted with no complications. Upon follow-up, the patient reported drastic pain reduction.ConclusionOur case illustrates neuromodulation benefits for a rare presentation of refractory occipital neuralgia secondary to Tourette’s-related dystonia. Occipital PNS should be considered for refractory cases because it is safe, easy to implant, and effective.
Aspirin and poetry: did João Cabral de Melo Neto suffer from acetylsali- cylic acid-overuse headache?
Authors: Cardoso Milena Débora , Neto Pedro Teixeira de Meneses
Published: January 2024

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Peripheral nerve block in a migraine pregnant patient: a case report
Authors: Sampaio Rhina de Freitas , Lira Lucas Antônio Martins , Neri Pedro Vinicius da Silva , Carvalho Pedro Rubens Araújo , Queiroga Morgana Feitosa de , Lima Gabrielle Benevides , Guedes Matheus da Costa , Assunção Robson Caetano Guedes , Ribeiro Ian Silva , Lôbo Camila de Oliveira , Silva Carla Welch da , Júnior Luiz Gonzaga Nogueira , Carvalho Joao Jose Freitas de , Alcantara Raimundo Neudson Maia , França Mário Hermes Rios
Published: January 2024

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Warning signs in pediatric headache: a literature review
Authors: Pinheiro Giulia Rebouças , Nunes Melyssa Maria Fernandes da Rocha , Azevedo Marina Pinheiro Uchoa , Filho Otavio Pereira da Silva , Lousada Lívio Martins , Coutinho Isadora Pinheiro , Soares Ana Clara Mendes , Moura Lucas Eliel Beserra
Published: January 2024

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Caffeine as adjuvant therapy for Tension-Type Headache: A systematic review
Authors: Lima Pedro Lucas Grangeiro de Sá Barreto , Castro Júlia Viana de , Aquino Luciana Alencar Fialho Bringel , Junior Pedro Helder de Oliveira , Barros Lívio Leite , Junior Fernando Antonio Guimaraes , Araújo David Augusto Batista Sá , Vasconcelos Sophia Costa , Melo Leonardo José Rodrigues de Araújo , Nóbrega Paulo Ribeiro
Published: January 2024

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