bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between self-control and satisfaction in life among Filipino older adults
Authors: Caorong Laarni
Published: June 2022

Introduction: Self-control has been associated with a host of positive life outcomes. This correlational study was aimed at determining the link between self-control and life satisfaction among the older population.

Methods: This study used a quantitative correlational design. Ninety-six (96) older adult residents of Iligan City and Lanao del Norte, Mindanao Philippines, who met the inclusion criteria were recruited. This quantitative study made use of two standardized instruments namely the Brief Self-Control Scale (BSCS) and the Satisfaction with Life Scale (SWLS). The association was assessed using Pearson correlation statistics.

Results: There is a significant relationship between the older adults’ self-control and their life satisfaction. The computed r value is 0.248 (p < 0.05). Evidently, there is a positive relationship between self-control and life satisfaction. This current study has provided evidence to support the assumption that exercising self-control leads to life satisfaction.

Conclusions:
As a significant positive relationship between the older adults’ self-control exercise and their life satisfaction was proven, this means that effective exercise of self-control positively leads to better life outcomes such as satisfaction in life.  Linking self-control exercise with life satisfaction offers an innovative way for us to know why some people may feel more satisfied with life than others.
Optimal Diaphragmatic Breathing Patterns through Exercise Can Light Some Medical Problems
Authors: Marufah Asmaul Lutfi , Zuhair Hilmy Yafi , Hanum Ulfi Qomariyah , Rubiyanto Agus , Dewayani Astri , Latief Abdurachman
Published: June 2022

Breathing is an absolute human need. In an emergency, airway and breathing are the main problems that must be addressed immediately. Empirically, breathing techniques that people do in general are varied. Of all breathing patterns, it is believed that there must be the most optimal. One of them is diaphragmatic breathing (DB). DB plays the role of the diaphragm as the main muscle that performs the activity of inhaling and exhaling. Optimal breathing patterns, including certain DB, have the ability to relieve several medical problems. The aim of this study was to examine whether an optimal DB pattern could alleviate some medical problems. We conducted a literature study on 40 references consisting of 27 journals and 13 other appropriate literature sources. We searched library resources using the PubMed search engine through keywords: effectiveness of breathing, DB, and breathing exercises. Literature analysis was based on requirements, including inclusion and exclusion criteria. There were 26 journals which met the criteria. Optimal DB pattern can be a solution for chronic obstructive pulmonary disease (COPD), asthma, chronic stroke, congestive heart failure (CHF), gastroesophageal reflux disease (GERD), cerebral palsy (CP), labor pain management, and anxiety. It can be therapeutic to relieve some medical problems.
Respiratory Bronchiolitis-Interstitial Lung Disease in Chronic Kidney Disease Mimicking Uremic Lung: A Case Report
Authors: Yanti Budi , Mauliza Mauliza , Sofiana Debby , Shehzad Aamir
Published: June 2022

Introduction: Uremic lung is a frequent complication of chronic kidney disease (CKD), while interstitial lung is an inflammation of the parenchyma which impairs its capacity. These two conditions manifest similar radiological features with bilateral diffuse infiltrates. Therefore, their clinical appearance and radiological lesions are often mistaken.
Case: This study reported a case of a 55-year-old male patient with shortness of breath for 1 month and worsening 1 week before hospitalization. The patient had a smoking history for 30 years with severe Brinkman index, hypertension (HT), and diabetes mellitus (DM). Auscultation examination showed crackles in both lungs, while laboratory results showed anemia, leukocytosis, increased urea and creatinine levels, and radiological features of bilateral infiltrate suggesting a uremic lung. Furthermore, the ultrasonography showed bilateral chronic pyelonephritis and was diagnosed with CKD, uremic lung, pneumonia, anemia, hypoalbuminemia, mild hypokalemia, DM, and HT. The patient was treated with regular hemodialysis three times a week, and the serial chest X-ray after hemodialysis showed persistent bilateral infiltrates. An MSCT examination was also performed, and the results showed respiratory bronchiolitis-interstitial lung disease (RB-ILD). The patient was treated with antibiotic therapy, inhaled salbutamol, systemic steroids, and mucolytics. The patient was discharged from the hospital after the respiratory complaint were improved.
Conclusion: In uremia patients with bilateral infiltrates resembling uremic lung and unresponsive to hemodialysis or other therapies, interstitial illness should be explored. To improve patient management, risk factors for suspected interstitial lung disease should always be examined.
Risk Factors and Challenging Management of Lung Adenocarcinoma in Young Adult Women: Case Series
Authors: Kusumawardani Ida Ayu Jasminarti Dwi , Karang Luh Komang Ayu Widhiaty , Candrawati Ni Wayan , Saputra Herman , Sriwidyani Ni Putu , Azizan Nornazirah Binti
Published: June 2022

Introduction: Lung cancer found in young age is relatively rare with a percentage of cases only 1.4% of overall lung cancer cases in the world.
Case: We reported two cases of lung adenocarcinoma in young women aged less than 30. The first case was lung adenosquamous carcinoma in a 28-year-old woman, a passive smoker, who had a family history of cancer. She had the mutation of epidermal growth factor receptor (EGFR) exon 19 deletion and received 1st generation of tyrosine kinase inhibitor. Since the patient was diagnosed at advanced stage with poor performance status, she died within 2 months after being diagnosed. The second case was lung adenocarcinoma in a 23-year-old woman. The patient was a passive smoker and had a history of cancer in the family. She was diagnosed at an advanced stage but with good performance status. The patient underwent chemotherapy with Pemetrexed-Platinum in 6 cycles and 15 cycles of radiotherapy.
Conclusion: Lung cancer at a young age is more common in non-smoking female with the histopathology type adenocarcinoma. Non-specific early symptoms become a problem in the early enforcement of lung cancer at a young age. Many cancer-related issues occur in young cancer patient such as premature death, increased dependence on parents, difficulty in school and work due to medication, and reproductive disturbance.
POLA PENINGKATAN SUHU UDARA BERDASARKAN DATA BMKG DAN ERA5 DI PROVINSI SULAWESI TENGAH
Authors: Alfiandy Solih , Rangga Imron Ade , Permana Donaldi Sukma
Published: June 2022

Studies  on  the  trend  analysis  of  surface  air  temperature  have  never  been  conducted  in  Central  Sulawesi  Province. This study aims to determine changes in the average surface air temperature trend in Central Sulawesi Province period 1981 to 2019. Linear regression analysis is used to identify the trend of temperature changes over a  certain  period.  The  results  show  that  the  average  surface  air  temperature  is  significantly  increased  by  0.015 –0.045°C  per  year  (p  <  0.05).  The  results  provide  the  information  on  climate  change  analysis  that  the  average surface air temperature has increased in Central Sulawesi Province over 39 years.
CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a
Authors: Du Wenqi , Liu Zongxiang , Zhu Wentao , Li Tongtong , Zhu Zhiman , Wei Lulu , Song Jun , Pei Dongsheng
Published: June 2022

Objective: CSN6 is a vital subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is responsible for development disorders and promotes ubiquitin-26S proteasome-dependent degradation in vitro and vivo. Its role in the tumor development of gastric cancer remains unclear. In this study, we investigated the role of CSN6 in gastric cancer progression. Methods: Human gastric cancer samples were collected and immunohistochemistry was performed to identify the role of CSN6 in gastric cancer. The cell proliferation was measured by CCK-8 and the EdU incorporation method. Immunofluorescence localization and a co-immunoprecipitation study were used to show the interaction between the protein CSN6 and p16. Ubiquitination assay was performed to validate whether ubiquitination is involved in CSN6-mediated p16 degradation. BALB/c nude mice were used to produce a tumor model in order to test the effect of CSN6 on cancer growth in vivo. Results: CSN6 expression was dramatically increased in gastric cancer tissues compared with paired adjacent non-tumor tissues and CSN6 was correlated with worse overall and disease-specific survival. Additionally, we also found that CSN6 downregulated p16 protein expression, thereby promoting gastric cancer cell growth and proliferation. Moreover, CSN6 interacted with p16 and a proteasome activator REGγ (PA28γ), thereby facilitating ubiquitin-independent degradation of p16. Conclusions: CSN6 promoted the loss of p16-mediated tumor progression and played an important role in regulating ubiquitin-independent proteasomal degradation of p16.
A Study of McVittie Spacetime in Stationary and Dynamical Regime
Authors: Bhattacharyya Indranath , Ray Saibal , Nag Riju , Nag Samudra Sundar
Published: June 2022

One of the solutions of the Einstein equations, called McVittie solution, signifying a black hole embedded by the dynamic spacetime is studied. In the stationary spacetime the Mcvittie metric becomes the Schwarzschild-de Sitter metric (SdS). The geodesic of a freely falling test particle towards the black hole is examined in the SdS spacetime. It is found that unlike Schwarzschild case the potential of such particle becomes maximum at a point where it eventually stops to follow an unstable circular motion and then resumes its motion towards black hole center. It is shown that an observer or system of particles is spaghettified near the black hole singularity in the SdS spacetime. The dynamic of the universe in the framework of McVittie metric, being a generalized time dependent SdS solution, is represented in terms of that point, called stationary or turning point. The motion of the stationary point is studied in various regimes of the expanding universe and the possible outcomes are discussed in brief.
Altered RNome expression in Murine Gastrocnemius Muscle Following Exposure to Jararhagin, a Metalloproteinase from Bothrops Jararaca Venom
Authors: Nascimento Andrezza , Zychar Bianca Cestari , Pessôa Rodrigo , Duarte Alberto José da Silva , Clissa Patrícia , Sanabani Sabri Saeed
Published: June 2022

Small RNAs (sRNA) and microRNAs (miRNAs) are small endogenous noncoding single-stranded RNAs that regulate gene expression in eukaryotes. Experiments in mice and humans have revealed that a typical small RNA can affect the expression of a wide range of genes, implying that small RNAs function as global regulators. Here, we used small RNA deep sequencing to investigate at how jararhagin, a metalloproteinase toxin produced from the venom of Bothrops jararaca, affected mmu-miRs expression in mice 2 h and 24 h after injection. The findings revealed that seven mmu-miRs were substantially differentially expressed (p-value (p (Corr) cut-off 0.05, FC 2) at 2h after jararhagin exposure, and that the majority of them were upregulated when compared to PBS. In contrast to these findings, a comparison of Jar 24h vs PBS 24hrs demonstrated that the majority of identified mmu-miRs were downregulated. Furthermore, the studies demonstrated that mmu-miR can target the expression of several genes involved in the MAPK signaling pathway. The steady antithetical regulation of mmu-miRs may correlates with the expression of genes that trigger apoptosis via MAPK in the early stages, and this effect intensifies with time. The findings expand our understanding of the effects of jararhagin on local tissue lesions at the molecular level.
El sector servicios en las ciudades fronterizas del norte de México
Authors: Manzanares Rivera José Luis
Published: June 2022

El presente artículo estudia el crecimiento reciente del empleo en el sector servicios en la frontera Norte de México. La hipótesis presentada asume que la desagregación del sector en sus dos componentes, servicios al consumidor y servicios al productor contribuye al entendimiento del impacto de sus determinantes. La fuente de infamación primaria son los censos económicos publicados por INEGI en el periodo 1988-2004. La estrategia metodológica se basa en un análisis econométrico, mediante un modelo con estructura de panel.
Political competition and the (in)effectiveness of redistribution in a federation
Authors: Kochi Ikuho , Ponce Rodríguez Raúl Alberto
Published: June 2022

En este ensayo se analizan las condiciones económicas y políticas en las que la efectividad de la redistribución pública puede ser baja en una federación. En nuestra economía el gobierno central redistribuye el ingreso mientras que los gobiernos locales proveen bienes públicos que benefician, primordialmente, a individuos de bajo ingreso. Si el gasto público local disminuye como respuesta a la política de redistribución del gobierno central entonces esta política podría ser inefectiva en redistribuir el bienestar de la sociedad. En este ensayo analizamos este tema. Los principales resultados de este estudio, son: primero, si el partido en el gobierno local de alguna entidad representa una coalición de votantes con un ingreso laboral por debajo del ingreso promedio de la economía, y si la transferencia neta agregada de recursos derivada de la política redistributiva del gobierno central es negativa para los residentes de esta localidad, entonces el gasto publico decrece en esta entidad si es que el gobierno central implementa una política de redistribución del ingreso; segundo, si los gobiernos locales son controlados por partidos políticos que representan a votantes con una elevada utilidad marginal de ingreso y un ingreso laboral por debajo de la media nacional, entonces la redistribución pública induce a todos los gobiernos locales a reducir el gasto público local.
Desplazamientos forzados: migración e inseguridad en Ciudad Juárez, Chihuahua
Authors: Velázquez Vargas María del Socorro
Published: June 2022

El presente escrito tiene como objetivo estimar los impactos cuantitativos de la actual crisis de violencia e inseguridad sobre los movimientos de población en Ciudad Juárez, a fin de visualizarlos como un desplazamiento forzado en situación de “crisis social”. En este sentido, pone en el centro de la discusión –al menos para esta urbe fronteriza- la necesidad de reformular en un plano teórico los factores explicativos que tradicionalmente se han asumido para entender el complejo fenómeno migratorio interno e internacional. La información utilizada proviene de los Censos de Población del Instituto Nacional de Estadística Geografía e Informática (INEGI), de la Agencia Estatal de Investigaciones y de la Encuesta de Percepción Ciudadana sobre Inseguridad en Ciudad Juárez (EPCIJ, 2009 y EPCIJ, 2010).
Time-Sensitive Characteristics of Bedding Shale Deterioration under the Action of Drilling Fluid
Authors: Changhao Wang , Ling Zhang , Shibin Li , Huizhi Zhao , Kai Liang , Xiaoming Wang , Chunhua Wang
Published: June 2022

Fractures continuously extend and expand along bedding shale formations under the action of drilling fluid and eventually form a complex fracture network, which greatly reduces the strength of the rock. To determine the effect of the drilling fluid action time on the physical and mechanical properties of shale, nuclear magnetic resonance tests are carried out on shale soaked in oil-based drilling fluid for different soaking times. The fluid absorption rate of shale takes the form of a power function. The equations relating the shale mass, porosity, and permeability to soaking time are established. Then, in a sonic time-difference test, the change in the dynamic elastic parameters with the immersion time are observed. According to a triaxial strength test, the failure form and the deterioration degrees of the layered shale in different loading directions with immersion time are analyzed. Numerical simulation of the deterioration degree of shale under different water content conditions is carried out. When the water content increases, the collapse density of the surrounding rock of the well wall increases significantly. Finally, considering the anisotropy of bedding shale, the inclination angle, azimuth angle, and drilling fluid immersion time are substituted into the rock mechanics parameter deterioration model, the three pressure profiles of the formation are corrected, and the safe drilling fluid density window of the target interval is given.
Impacto de la pandemia de Covid-19 en el tamizaje de cáncer de mama y algunas estrategias para actuar pronto y seguro
Authors: Sollozo-Dupont Isabel , Galván-Espinoza Héctor Alejando , Castillo-López Jorge Patricio , Benítez-López Erick Octavio , Rocha-Nava Sandra Luz , Villaseñor-Navarro Yolanda
Published: June 2022

Desde el comienzo de la pandemia de Covid-19 los servi­cios de prevención de cáncer de mama han sido aplazados gravemente. Esta acción provocó la reducción en el número acumulado de mastografías de detección a nivel mundial e incrementó las disparidades en salud, sobre todo entre las mujeres vulnerables. Si bien la evidencia que respalda las es­trategias para rescatar el tamizaje con mastografía en la fase de resolución de la pandemia no es suficiente, hay algunas consideraciones pragmáticas que pueden guiar su recupera­ción y garantizar su continuidad. Una de estas estrategias es prever los retrasos en el tamizaje y abordarlos a través de programas seguros que se alineen con la situación epidemio­lógica actual. Las acciones planteadas en el presente ensayo están en consonancia con las iniciativas internacionales de garantizar la continuidad de los programas de tamizaje de cáncer de mama en atención a que el cuidado de las mujeres sea una acción prioritaria, continua y permanente.
Medidas terapéuticas para mujeres agredidas en tiempos de Covid-19
Authors: Carlos-Gutiérrez Liliana Rosa , Gutiérrez-Calderón Hilda Rosa
Published: June 2022

No disponible
Hydrogen Storage to Decarbonize Austria's Energy Consumption
Authors: Clemens Marcel , Clemens Torsten
Published: June 2022

The European Union is aiming at reaching greenhouse gas (GHG) emission neutrality in 2050. Austria's current greenhouse gas emissions are 80 million t/year. Renewable Energy (REN) contributes 32 % to Austria's total energy consumption. To decarbonize energy consumption, a substantial increase in energy generation from renewable energy is required. This increase will add to the seasonality of energy supply and amplifies the seasonality in energy demand. In this paper, the seasonality of energy supply and demand in a Net Zero Scenario are analyzed for Austria and requirements for hydrogen storage derived.

We looked into the potential usage of hydrogen in Austria and the economics of hydrogen generation and technology and market developments to assess the Levelized Cost of Hydrogen (LCOH). Then, we cover the energy consumption in Austria followed by the REN potential. The results show that incremental potential of up to 140 TWh for hydropower, photovoltaic (PV), and wind exists in Austria. Hydropower generation and PV is higher in summer- than in wintertime while wind energy leads to higher energy generation in wintertime. The largest incremental potential is PV, agrivoltaic is significantly increasing the area amenable for PV compared with PV usage only. Battery Electric Vehicles (BEV) and Fuel Cell Vehicles (FCV) are using energy more efficiently than Internal Combustion Engine (ICE) cars, however, the use of hydrogen for electricity generation is significantly decreasing the efficiency due to electricity — hydrogen — electricity conversion.

The increase in REN use and the higher demand for energy in Austria in wintertime require seasonal storage of energy. We developed three scenarios, Externally Dependent Scenario (EDS), Balanced Energy Scenario (BES) or Self-Sustained Scenario (SSS) for Austria. The EDS scenario assumes significant REN import to Austria whereas the SSS scenario relies on REN generation within Austria. The required hydrogen storage would be 10.82 bn ms for EDS, 13.34 bn ms for BES, and

18.69 bn ms for SSS. Gas and oil production in Austria and the presence of aquifers indicates that sufficient storage capacity might be available. Significant technology development is required to be able to implement hydrogen as energy carrier and to balance seasonal energy demand and supply.
A Semi-Analytical Model for the Prediction of CO2 Injectivity into Saline Aquifers or Depleted Hydrocarbon Reservoirs
Authors: Whittle Tim , Park Philippa , Coll Carolina
Published: June 2022

As carbon dioxide (CO2) is injected into a reservoir (for CO2 sequestration in a saline aquifer or depleted reservoir, or even for enhanced oil recovery in the case of a less depleted reservoir), a region around the well becomes saturated and expands with time. From a pressure transient perspective, by making some simple assumptions the resulting reservoir configuration at any given moment can be approximated by a two-region radial composite system. As well as its radial extent, the inner region is defined by its diffusivity and mobility, both of which differ from those of the outer region as a result of the CO2 saturation. The CO2 viscosity and compressibility at reservoir pressure and temperature are the essential properties that impact the diffusivity and mobility. Knowing the three variables, radius, diffusivity ratio and mobility ratio, the constant rate pressure transient response is readily computed from existing analytical radial composite model solutions. These are commonly used in the petroleum industry to analyse well test behaviour and can be configured with a variety of boundary conditions (no flow, constant pressure or infinite, usually in the shape of a rectangle).

The problem with CO2 injection is that the radius and properties of the inner zone vary with time and hence any single radial composite model does not apply. The solution approach in this paper is to apply superposition. At each discretised time step, the well is simultaneously injected at a constant rate assuming the current configuration and shut in with the previous configuration. The shut-in "cancels out" the previous model and the current model applies. At each time step, the injected volume is calculated, the material balance and associated reservoir pressure computed along with the new inner zone radius, diffusivity and mobility and hence the model for the next time step is defined. An additional iterative loop allows for the injection rate to decrease if the injection pressure exceeds a maximum constraint.

The method is simple and fast and appears to match the pressure response of numerical simulations of the same problem using more detailed physics, without the associated noisy derivative often associated with grid-based solutions. It implicitly assumes a piston like displacement which results in an unrealistic saturation profile that differs from the more rigorous numerical models where gravity and capillary effects are included. However, comparisons with such models indicate that the prediction of well pressure and hence injectivity is sufficiently accurate for practical purposes despite this approximation.

The application of superposition in time - a method usually associated with solving linear problems – is demonstrated to adequately solve the complex non-linear problem of CO2 injectivity and, because the method includes material balance, it can help to define storage efficiency factors which are critical for the evaluation of storage capacity.
Dynamic Behavior of Salt Dissolution and Its Effect on Imbibition in Inter-Salt Oil Reservoir Due to Fracturing Fluid Injection
Authors: Liu Xiliang , Chen Hao , Yang Jin , Yang Shenglai
Published: June 2022

Billions of tons in proven reserves for inter-salt shale oil has been recognized as crucial strategic resources. The fracturing fluids injection triggers unique salt dissolution chemical phenomena, which on the one hand improves the reservoir pore structure and on the other hand easily induces formation collapse. However, there is no research on triggering mechanism and controlling factors of salt dissolution, and effect of slat dissolution on extremely important imbibition function in inter-salt shale formation is lack of understanding. Herein, the complex mechanism of inter-salt shale dissolution reaction was revealed based on microcosmic pore structure network. The effect of salt dissolution on imbibition in inter-salt shale formation was assessed from various angles, which was conducted by online nuclear magnetic resonance (NMR), high-quality focused ion beam scanning electron microscopy (FIB-SEM), and CT technologies. The results indicate that high temperature improves slat dissolution reaction and enhances the seepage capacity by more than 60 times, which sharply exceeds the influence of fracturing fluid salinity, flow rate and pressure in inter-slat formation. Three kinds of pores for imbibition recovery contribution were 48.17%, 46.39%, and 5.44%, namely micropore, mesopore and macropore, respectively. Additionally, salt dissolution enlarged seepage channel so that spontaneous imbibition occurred in micropores, which was considered as conventionally unmovable areas. Besides, the salt dissolution effect mainly promoted oil discharge in the second stage of imbibition process, leading to 15.83% higher imbibition recovery. These results can furnish an in-depth understanding the nature of complicated mechanisms in inter-slat shale oil reservoirs with fracturing fluids injection.
Energy Transition by Employing a Self-Healing, Reduced Carbon Dioxide Footprint Sealant in a Strategic Underground Gas Storage Project
Authors: Johnson Carl R. , Sari Suleyman , Ahrenst Alex , Gozubuyuk Irem
Published: June 2022

The Tuz Gölü underground gas storage (UGS) project is a strategic venture in Turkey's energy program. This gas storage facility will be the largest in Europe, having multibillion m3 capacity, by taking advantage of the optimal gas storage conditions offered by subterranean salt caverns. Upon reaching the reservoir, one of the important goals is to obtain hydraulic isolation between the surface and the casing. Inadequate downhole isolation may well result in interzonal communication, gas migration, casing corrosion, and sustained casing pressure. Furthermore, gas flow to surface formations and/or to the atmosphere, could impact the environment and health along with an underlying economic impact. Wellbore isolation was introduced in the form of fully salt-saturated gas control and self-healing cement systems.

When drilling into salt caverns, the foremost challenge is to minimize the dissolution of the in-situ salt formation by means of contact with water-based cementing fluids, which can lead to the creation of new flow paths. This occurrence must be prevented at all costs; otherwise, stored gas might leak through these microchannels. Unlike typical salt formations, this candidate field also contains carbon dioxide (CO2). Most wells in the field had a prognosis toward low CO2 content, so cement exposure to CO2 was not deemed an elevated risk; however, if the CO2 exposure risk increased, it would potentially generate an additional challenge both in terms of gas migration control and long-term cement integrity.

Currently, more than 100 cementing operations have been performed in the candidate field. After pumping 3,500 metric ton of cement and blending 750 metric ton of the tailored self-healing cement, more than 300 laboratory tests were performed. More than 15,000 staff-hours of testing supported construction of 32 UGS wells, fully cemented with zero health, safety, and environment (HSE) or service quality incidents and, importantly, with outstanding bond log results. Completion strings in 15 wells have already been run where wells are prepared to store gas; the ongoing project is now expanded to 50 UGS wells. Furthermore, an intrinsic benefit of the self-healing cement system is reduced CO2 footprint vs. conventional class G cement, which can be nominally 40% less CO2 per unit volume.

With involvement of local laboratories and technical experts in the region, salt-saturated gas-control and self-healing cement slurry systems have been developed and successfully deployed. Information regarding these system's liquid and set properties will be presented, along with techniques used to enhance certain cement properties. The field cases that will be presented describe how challenges were overcome in successfully sealing UGS wells in a highly saline environment, and how the self-healing technology applied in these wells is being extended to include salt-saturated systems and CO2-resistant versions elsewhere.
Artificial Intelligence for Production Optimization in Schoonebeek Thermal EOR Field
Authors: Arfie Mezlul , Ghodke Nikhil , Groenbroek Kasper
Published: June 2022

Production from the Schoonebeek heavy oil steam flood in northeast Netherlands was historically curtailed because of limits on H2S and water production. The interdependence of various permit and facility constraints makes production optimisation for Schoonebeek extremely challenging. So much so, that the conventional IPSM approach does not apply. To understand the field's production potential and to reach it, the team developed a novel Production System Optimisation (PSO) workflow using techniques from machine learning and operations research. In this paper we explain the details of this PSO workflow, the mathematics behind it, and share our results and learnings. The algorithm runs in 5 minutes and is used in daily optimisation. The application of this new workflow in combination with the successful deployment of a novel H2S scavenger, resulted in a Schoonebeek production uplift of 50%.
Examination of Five Amino Acids as Gas Hydrate Kinetic Inhibitors in Oil and Gas Industry
Authors: Longinos Sotirios , Longinou Dimitra -Dionisia , Wang Lei
Published: June 2022

Gas hydrates are acquainted as a significant topic to the oil and gas flow assurance, as it creates pipelines occlusions. The formation of gas hydrates can create many functional issues such as: stop of production, high preservation expenditures, environmental dangers and even loss of human beings. In this work five different amino acids such as: leucine, methionine, phenylalanine, glycine and asparagine examined if they work as kinetic inhibitors on mixture gas hydrate formation. The outcomes indicated that phenylalanine, asparagine and glycine (phenylalanine>asparagine>glycine) behaved as inhibitors following the rank from most powerful to less one while leucine and methionine behaved as promoters (leucine>methionine) for both hydrate formation and induction time.
Using a CCS Simulator to Maintain Liquid CO2 in the Completion
Authors: Petitt Anna Helene , Konopczynski Michael Robert
Published: June 2022

Depleted oil and gas fields may provide important locations for Carbon Capture and Storage (CCS). However, injection of carbon dioxide into pressure depleted oil and gas fields can be problematic due to the low reservoir pressure and the phase change behavior of carbon dioxide. The change of carbon dioxide from a liquid into a gas can trigger physical phenomena, such as significant cooling of the fluid as a result of the Joule-Thomson effect and the latent heat of vaporization, which can cause material embrittlement and loss of equipment functionality, and unstable or surging injection rates. Current mitigations restrict the quantity of carbon dioxide able to be injected by use of multiple injection tubing strings that can be costly or technically prohibitive. A more attractive alternative may be the use of downhole variable flow restricting devices which will autonomously respond to the changing well conditions, without the need for intervention or a workover in later well life.

There is limited software currently available to model flow control to ensure carbon dioxide remains in liquid form in the completion. Through nodal analysis, the CCS simulator developed in this study can simulate the choking effect of downhole flow control devices placed at intervals in the completion that are sized and numbered to achieve the desired pressure distribution and CO2 injection rate. The modelling can then illustrate the required operating parameters of the downhole flow control solution with the results indicating the equivalent orifice sizes required for the flow control devices. The adjustable flow control devices can be removed or fully opened when the reservoir pressure increase and injection rate climbs and thus deemed to be no longer necessary. The use of downhole flow control devices can replace the need for a multiple string completion as the reservoir pressures and injection rates vary over the life of the well.
A Prospective Cohort Study: Platelet-Rich Plasma Combined with Carpal Tunnel Release Treating Carpal Tunnel Syndrome short (running) title: PRP-CTR Treating Carpal Tunnel Syndrome
Authors: Gao Yan-chun , Wang Qi-yang , Wang Chen-chen , Chen Hua
Published: June 2022

Background
PRP injection was proved to promote the health condition of individuals with mild to moderate Carpal Tunnel Syndrome (CTS). However, carpal tunnel release (CTR) was still an important treatment for individuals with moderate, as well as severe CTS.
Methods
To explore whether adjuvant PRP treatment would improve the prognosis while using CTR, we included 82 patients in this study. Preoperative and postoperative visual analog scale (VAS), Boston carpal tunnel syndrome questionnaire-symptom severity scale (BCTQ-SSS), Boston carpal tunnel syndrome questionnaire-functional status scale (BCTQ-FSS), and grip strength was used to examine the patient's symptoms and function.
Results
CTR combined with PRP treatment improved the VAS (1.9 ± 0.5 versus 1.4 ± 0.4, P < .05), BCTQ-SSS (1.8 ± 0.4versus 1.5 ± 0.3, P < .05) and BCTQ-FSS (1.8 ± 0.5 versus 1.4 ± 0.6, P < .05) in patients with moderate symptoms within one month after surgery. At the same time, it does not show any advantages in treating individuals with severe carpal tunnel syndrome.
Conclusions
The use of PRP does not affect long-term prognosis while increasing the surgery cost. To conclude, PRP as an adjuvant treatment of CTR has limited effect. Considering the additional financial burden on patients, CTR combined with PRP should be cautious in CTS treatment.
Linkage of proteasomal impairment and autophagy activation by C9orf72 poly-GA aggregate formation
Authors: Pu Mei , Tai Yusi , Yuan Luyang , Zhang Yu , Guo Huijie , Hao Zongbing , Chen Jing , Qi Xinming , Wang Guanghui , Tao Zhouteng , Ren Jin
Published: June 2022

Background
Poly-GA, a dipeptide repeat protein unconventionally translated from GGGGCC repeat expansions in C9orf72, is abundant in C9orf72-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although the poly-GA aggregates have been identified in C9orf72-ALS/FTD neurons, the effects on UPS and autophagy, and their exact molecular mechanisms have not been fully elucidated.
Results
Herein, our in vivo experiments show that ploy-GA mice expressing 150 repeats but not 30 repeats GA exhibit significant aggregates in cells, behavioral deficits, and activate autophagy in the brain. The in vitro results demonstrate that the aggregated poly-GA induce proteasomal stress through directly binding proteasome subunit PSMD2 to recruit proteasome and impair its function, subsequently activate phosphorylation and ubiquitination of p62 to recruit autophagosome, and ultimately leading to compensatory autophagy activation. While rapamycin treatment significantly improves the degenerative symptoms of mice expressing 150 repeats poly-GA, relieves neuronal injury and reduces neuroinflammation and aggregates in the brain.
Conclusion
In summary, we clarify for the first time the relationship of poly-GA between proteasome and autophagy: poly-GA aggregates recruit autophagosomes only when it forms complex with the proteasome and causes proteasomal stress. Our study provides support for further promoting the comprehension about the pathogenesis of C9orf72 and may bring a hint for the exploration of rapamycin in the treatment of ALS/FTD.
Towards Cognitive Critical Discourse Analysis CCDA Methodology A multidisciplinary approach to Social Science
Authors: Allah Ghufran Khir
Published: June 2022

This paper introduces a comprehensive CCDA methodology that bridges CL and CDA. CCDA depends on two main approaches studied extensively in Linguistics Approach in the last decades; the first is Cognitive Linguistics (CL) (which contains theories on Mental Frames (MF) and Conceptual Metaphors Theory (CM). The second is Critical Discourse Analysis (CDA) which includes the analysis of the linguistic production (the discourse) and the social and political context of that production (political agenda, injustice, social stereotypes, and equality). This paper aims to join all the previous attempts to join CL into CDA in one comprehensive methodology for social science researchers with essential linguistic backgrounds. Contrary to the already existing CL theories, which consider MF as the output of CM analysis, CCDA argues that the analysis of the non-metaphorical linguistic choices is another essential tool to identify dominant framings of the social phenomena and the linguistic structures related to them. In CCDA, MF and CM analysis are separated but correlated analysis fields in CL. CCDA goes beyond the linguistic structures to reveal the dominant framing that control people’s minds on social phenomena.
Analysis of the Relationship between Innovation and Ethipian Economic Growth
Authors: abibo abebaw , Muchie Mammo , Sime zerayehu , Ezezew Wondemhunegn
Published: June 2022

Economists all over the world believe and recognize that innovation promotes economic progress. This research examines the relationship between Ethiopian economic growth and innovation. The goal of this article is to see if an economy's innovation potential has an impact on long-term growth in the economy of Ethiopia. The analysis used data from 1987 to 2020 year in the case of Ethiopia, time-sires data and analysis were carried out using ARDL estimates. The study examined a variety of indicators to quantify innovation, including the number of patents, R&D expenditures, education spending, and enrollment ratio. The results provide evidence of a positive relationship between economic growth and innovation (patents, R&D expenditures) as well as human capital (Education enrollment ratio education spending). The result also shows that both labour and capital are directly related to economic growth, though the former plays a significant role while the latter does not. This paper recommdan that the government is committed to R&D and education funding, developing strong institutions, enhancing the academia-industrial linkage as well as implementing a workable science, technology, and innovation policy to bolster and diversify the economy. to encourage them to engage in R&D and education activities, either through reverse engineering or inventing new ones, as this will not only lead to economic growth but also raise the global competitiveness of Ethiopia's economy.
Selenium Regulated Growths and Response of Nutrients in Moringa oleifera Lam Under Arsenic Stress
Authors: Du Lijuan , Liu Xinyong , Yin Benlin , Yang Xukun , Yan Hongmei , Shao Jinliang , Wang Yunmei
Published: June 2022

Root is the primary organ directly exposed to As pollutants in soil, which uptakes have a closely effect on the accumulation and transportation of As. This study is intended to investigate the influence of Se on the growths and nutrients responding in Moringa oleifera Lam under As stress. The main results are: (1) The application of selenium can promote the growth of root, while the application of arsenic can inhibit the growth of it; (2) Contents of Se and As are the highest in the first treatment and the fourth treatment, and R-As of selenite application has a decreasing change in different parts of it; (3) Contents of organic Se and organic As are the highest in the first treatment and the fourth treatment and have the lowest at the same treatment as the highest concentration; (4) Contents of TAA and proteins are the highest in the first treatment and are the lowest with the fifth treatment. Met+Cys is the FLAA in Moringa oleifera. When different selenite and arsenite are applied. Different treatments of selenite and arsenite were positively correlated with As and the organic As contents, but negatively related with TAA and proteins. Through this research, the protection of Se on Moringa oleifera under the condition of As biological stresses will be analyzed, aimed at achieving functions of As descending and Se suppling by reasonable exogenous selenium applying. It will have a great significance to assure the quality and safety of agricultural products and human health.
Late Miocene-early Pliocene Palaeoenvironmental Changes in the Western Rifian corridor (NE Morocco)
Authors: RAHMOUNA JIHAD , BARHOUN nadia , RACHID ahmed , TARGHI soukaina , BAHAJ hannane , BERRY naima , YOUSFI mohamed zakaria
Published: June 2022

The Gharb basin constitutes the western part of one of the main corridors that connecting the Mediterranean Sea and the Atlantic Ocean during the Upper Miocene. This basin is characterized by a continuous sedimentary filling from the Upper Tortonian to the Pliocene, likely to record environmental information useful for the reconstruction and evolution of the marine environment before and during the Messinian salinity crisis.Based on an integrated study of the planktonic and benthic foraminifera of borehole DF 101 (Gharb basin, Morocco), the objective of this work is, on the one hand, to clarify the biostratigraphic framework of the sediments studied and, on the other hand, to make a further contribution to the reconstitution and evolution of the marine environment during the Upper Neogene in the Gharb Basin.The high-resolution biostratigraphic study of borehole DF 101 revealed the succession of eight bioevents and characterized the Upper Tortonian, Messinian and Zanclean.The composition of benthic foraminiferal assemblages, paleoecological indices and statistical analysis show an evolution of depositional conditions in terms of bathymetry and oxygen content from the Upper Tortonian to the Pliocene.The Upper Tortonian is marked by an association of very diversified benthic foraminifers that characterizes the upper bathyale, the estimated paleobobathymetry is over 800 m and the medium is well oxygenated. Messinian marl deposits are characterized by a decrease in bathymetry, and a reduction in the rate of oxygenation. While during the Lower Pliocene, the medium becomes relatively deeper, higher bathyal type and normal oxygenation rate.
Preparation of sulfonated coal@ZVI@chitosan-acrylic acid composite and study of its removal of groundwater Cr(VI)
Authors: Gao Jianlei , Feng Mengyuan , Yan Yixin , Zhao Zixu , Wang Yingchun
Published: June 2022

The effects of Cr(VI) pollution in groundwater run wide and deep. Without effective remediation, Cr(VI) harms the environment and human health. With in situ treatment methods in which permeable reactive walls serve as the main body, chitosan-acrylic acid sols (CS-AA) were used to stabilize zero-valent iron (ZVI), and acid-modified sulfonated coal (SC) was used as the carrier to prepare SC@ZVI@CS-AA. The interaction between SC@ZVI@CS-AA and Cr(VI) conformed to a pseudo second-order kinetic model suggesting chemisorption. The Langmuir model provided a good fit to the data for adsorption of Cr(VI) by SC@ZVI@CS-AA. SC@ZVI@CS-AA was characterized using XRD, FTIR, SEM and TG − DSC analyses. The effects of contact time, initial Cr(VI) concentration, temperature, material ratios, pH, dosage of SC@ZVI@CS-AA and interfering ions on the adsorption of Cr(VI) were investigated. Under the optimal conditions, the efficiency for removal of Cr(VI) reached 98.5%. The adsorption of Cr(VI) was significantly inhibited by SO42-. In addition, the capacity for adsorption of Cr(VI) by SC@ZVI@CS-AA remained above 70% after three use cycles. Overall, SC@ZVI@CS-AA proved to be a promising and environmentally friendly medium for removal of Cr(VI) from groundwater.
Synthesis and characterization of Novel Gadolinium doped CoCr2O4: Focus on Structural, Electric and Humidity Sensing properties
Authors: Ramprasad N. , Gowda G.V. Jagadeesha , Gowda K.V. Arjuna , Kantharaj K.S. , Tudorache Florin , Abdulvakhidov Kamaludin , Lyanguzov Nikolay , Yahia I.S. , Zahran H.Y. , Angadi jagadeesh
Published: June 2022

In this paper, we presented structural, Fourier infrared spectroscopic, and dielectric analysis of cobalt chromate (Co2+Cr23+O4) with 2 mole % of gadolinium (Gd3+) rare earth metal additions under humidity and non-humidity circumstances. The Gd3+ doped Co2+Cr23+O4 samples are prepared by solution combustion method and sintered for 2 hours at 650°C to get single phase. Doped and undoped samples were characterise X-ray powder diffraction (XRD) analysis provides the detailed formation of the Co2+Cr23+O4 phase and crystallinity. Furthermore, the average crystallite sizes are found in the range of 18 to 7 nm. The general nature of ferrite materials is revealed via FTIR analysis. The octahedral and tetrahedral stretching band in FTIR spectra were confirmed ferrite structure without impurity. We investigated the relevant conductivity of the samples, the reaction time of the capacitive sensor, and the humidity influence on the relative permittivity characteristics at a constant frequency range of f = 1 kHz. Our findings indicate that Gd3+ doped Co2+Cr23+O4 could be exploited as an active material in humidity sensor applications.
Standardization and Validation of a High Yield Conventional Platelet-rich Plasma Preparation Protocol
Authors: Muthu Sathish , Ramanathan Karthik Raja
Published: June 2022

Introduction: Platelet-rich plasma (PRP) has been demonstrated to benefit a variety of disciplines for diseases of inflammatory or degenerative origin. But there exists heterogeneity in the results obtained due to the lack of standardization of the preparation protocols employed in them. This study aims to identify and standardize a preparation protocol for PRP with maximum recovery of platelets to obtain reproducible results across studies. Materials & Methods: Blood samples were collected from 40 healthy volunteers who signed informed consent for participation in the study. The double spin protocol of PRP preparation was analyzed for variables such as centrifugal acceleration, time, and volume of blood processed and final product utilized. The final PRP prepared was investigated for platelet recovery, concentration, integrity, and viability. Each protocol investigated was run twice in all the samples to avoid reporting and sampling bias. Results: We noted maximum platelet recovery (86-99%) with a consistent 6.4±0.8 times baseline concentration of platelets with double centrifugation cycles at 100 and 1600g for 15 and 20 minutes respectively. We also noted that 10 ml of the volume of blood in a 15 ml tube was the ideal volume of blood to be processed to maximize platelet recovery. We noted the upper 2/3rd of the final product was free of platelets thereby making the lower 1/3rd the ideal volume to be utilized. We did not note a loss of integrity or viability of the platelets in the final product from the above-said protocol. Conclusion: Preparation of PRP by the double spin protocol of 10 ml of blood at 100g and 1600g for 15 and 20 minutes respectively in a 15ml tube and using the lower 1/3rd of the final product demonstrated consistent high platelet recovery (86-99%) and concentration (6x) without disturbing the platelet integrity or viability.