bluuebunny/crossref_metadata_2025 huggingface dataset:
Autonomy of individuals with alcohol-related disorders: informed consent
Authors: Azevedo João Paulo Barbosa
Published: February 2023

Abstract Informed consent, as a way to ensure involvement and treatment adherence, is part of the therapeutic approach to individuals with alcohol-related disorders. Autonomy, as a core ethical value, and its immanence for informed consent presents ethical-clinical challenges in the case of individuals seeking treatment due to coercion, anxiety, or depression. Between April 2018 and June 2019, a prospective longitudinal observational study was conducted with 150 people with alcohol-related disorders attending a specialized treatment facility. The goal was to verify whether consent obtained under coercion, or influenced by anxiety disorder or depression determines therapeutic participation. Absence of judicial coercion and anxious symptomatology and the greater value placed on perceived autonomy in informed consent were related to participation. The study proposes contributions to strengthen the practice of obtaining informed consent based on the recognition and promotion of autonomy.
Existential and bioethical aspects of palliative care in cancer
Authors: Langaro Fabíola , Schneider Daniela Ribeiro
Published: February 2023

Abstract Severe illness places individuals in direct confrontation with death, an element of the experience of living. A total of 12 interviews were conducted with adults undergoing palliative care in cancer, and investigated by phenomenological analysis, describing the axes of meaning produced in the narratives. Analysis of the ways individuals (re)organize their life projects based on illness and finitude identified three dimensions: spirituality/religiosity; life in the family; relationship with death. The meaning patients attribute to existential trajectories and the relationship established with their life project are essential for treatment adherence and coping with death. Resignifying life, illness and death can relieve suffering and help patients give meaning to the time left. Such questions help us reflect on the bioethical dimension of palliative care and enable planning in this modality of care.
Aspectos existenciais e bioéticos nos cuidados paliativos oncológicos
Authors: Langaro Fabíola , Schneider Daniela Ribeiro
Published: February 2023

Resumo O adoecimento grave lança o sujeito à facticidade da morte, que faz parte da experiência do viver. Realizaram-se 12 entrevistas com adultos em cuidados paliativos oncológicos, as quais foram analisadas sob a perspectiva fenomenológica, com descrição dos eixos de significado produzidos nas narrativas. Verificaram-se três dimensões do modo como as pessoas (re)organizam seus projetos de ser a partir do adoecimento e da finitude: espiritualidade/religiosidade; ser em família; relação com a morte. O significado atribuído às trajetórias existenciais e à relação estabelecida com projeto de ser são fundamentais para o paciente aderir ao tratamento e enfrentamento da morte. Além disso, ressignificar vida, doença e morte oferece alívio ao sofrimento e auxilia o paciente a dar sentido ao tempo que ainda lhe resta. Tais questões são importantes para refletir sobre a dimensão bioética nos cuidados paliativos e auxiliam no planejamento desta modalidade de atenção.
Implantação e implementação de serviços em cuidados paliativos
Authors: Kurogi Luciana Tiemi , Vieira Caroline Aparecida Leindecker Garçoa , Ramalho Rosa Maria , Silva Angelita Wisnieski da
Published: February 2023

Resumo Considerando que a demanda de ampliação de serviços de cuidados paliativos nos hospitais gerais do Brasil torna necessário enfrentar obstáculos e estabelecer estratégias para viabilizar a implantação desses serviços no sistema de saúde, buscou-se identificar o processo de implantação e a efetivação de serviços de cuidados paliativos em hospitais gerais do país. Mediante revisão integrativa da literatura, que consistiu na análise de quatro artigos, foram identificadas as seguintes etapas para implantação e efetivação de serviços de cuidados paliativos: elaboração de protocolo, cuidado humanizado, multidisciplinariedade e educação. Além disso, detectaram-se os desafios a seguir: ausência de treinamento e educação em cuidados paliativos, dificuldade de consenso sobre práticas paliativas, comunicação, oferta de fármacos e apoio dos governos. Considera-se que o estabelecimento de políticas públicas é essencial para garantir a implantação dos cuidados paliativos em hospitais.
“Isso vai ser um caos!”: distopia e autoritarismo em Namíbia, não!
Authors: Matias Anderson de Figueiredo
Published: February 2023

Resumo Este artigo analisa como a narrativa de Namíbia, não!, texto teatral do ator e diretor baiano Aldri Anunciação, elabora um universo distópico em que o cruzamento de temporalidades expõe contradições do passado, amplia a percepção sobre a violência racial do presente e realiza projeções de futuro em que a hostilidade e as interdições se materializam no espaço. Para isso, utiliza contribuições de intelectuais como Grada Kilomba (2019), em Memórias da plantação: episódios de racismo cotidiano; de Abdias do Nascimento (2004), em “Teatro Experimental do Negro: trajetória e reflexões”; de Leda Maria Martins (2020), em “Como respirar?”; e de Gregory Claeys (2017), em Dystopia: a natural history. A study of modern despotism, its antecedents, and its literary diffractions.
La regulación a prueba de futuro (“future-proof regulation”) como práctica de mejora regulatoria
Authors: Aponte William Ivan Gallo , Castillo Luis Ferney Moreno
Published: February 2023

Resumen El futuro de la regulación impone la necesidad de pensar en regulaciones para los tiempos y circunstancias que se avecinan. Las respuestas regulatorias a los diferentes problemas sociales, económicos y medioambientales se enfrentan a un amplio crecimiento y aceleración de la innovación y la tecnología. En este sentido, es necesario incorporar buenas prácticas regulatorias que respondan a los diferentes retos y paradigmas de manera equilibrada y racional, alejándose de las posiciones fundamentalistas. A partir de esta necesidad, y utilizando una metodología hipotético-deductiva, este artículo pretende analizar la “regulación a prueba de futuro” (“future-proof regulation”) como práctica regulatoria dentro del ecosistema regulatorio brasileño. Se concluye que, basándose en el principio innovador, este tipo de regulación se muestra como una herramienta que permite entender y responder a las diferentes necesidades sociales, económicas y medioambientales, así como a los cambios rápidos, disruptivos y transformadores, que traen consigo las nuevas tecnologías. Las regulaciones deben dar prevalencia a un amplio contenido de participación social y de diálogo técnico interdisciplinario para la gestión de los procesos y estrategias regulatorias. Sin embargo, diseñar regulaciones a través de herramientas y métodos para hacer que las políticas públicas sean más eficaces y con visión de futuro es un desafío para los reguladores. La regulación a prueba de futuro está concebida como un estímulo o estrategia frente a este desafío.
QUAL A POSIÇÃO DAS MULHERES NA REDE DE BOARD INTERLOCKING DO BRASIL? UMA ANÁLISE PARA O PERÍODO DE 1997 A 2015
Authors: Barros Thiago de Sousa , Kirschbaum Charles
Published: February 2023

RESUMO Até bem recentemente, os conselhos de administração das empresas apresentavam forte predominância masculina, imperando resultados controversos quanto à inserção das mulheres nesses órgãos. Em face disso, esta pesquisa teve como objetivo investigar a evolução da participação feminina nos conselhos de administração das empresas brasileiras listadas na B3 e a posição dessas conselheiras na rede corporativa de board interlocking, entre 1997 e 2015. Para entender esse fenômeno, foi adotada a metodologia Análise de Redes Sociais (ARS) e diversos indicadores foram calculados. Os resultados indicam que as mulheres aumentaram sua participação na alta administração do ambiente corporativo brasileiro e começam a integrar os conselhos de administração, cenário ainda distante da realidade observada em países desenvolvidos. No entanto, quando foram analisados os membros conectados na rede corporativa, concluímos que as mulheres alcançam alta proximidade, uma vez que têm alto grau de centralidade na rede, mas também carecem de potencial de intermediação. Tais resultados sinalizam a necessidade de aumentar a diversidade de gênero no alto escalão das empresas, o que poderia elevar a qualidade do debate nos conselhos de administração e melhorar os níveis de governança corporativa.
COPRODUÇÃO DE CONHECIMENTO EM GESTÃO EM (A PARTIR DE) PAÍSES E SOCIEDADES EMERGENTES
Authors: Faria Alexandre
Published: February 2023

RESUMO Em uma era de descolonização e império, o campo da gestão abraçou a contrarrevolução neoliberal liderada pelos EUA e desafiou a hierarquia eurocêntrica teoria-prática para produzir conhecimento relevante por meio de teorias de aprendizagem gerenciada. Contra a ameaça de “relevância reversa” promovida por bárbaros emergentes/ressurgentes essa contestada revolução gerencial (RG) reformista e mercadocêntrica subalterniza teorias-práticas sulistas do multifacetado campo de administração do desenvolvimento (AD) e “desdesenvolve” a maioria global ao privilegiar grandes corporações e elites transnacionais. A RG é expandida nos anos 1990 por meio de uma perspectiva social pós-Consenso de Washington baseada em dinâmicas reocidentalizantes branqueadoras de apropriação-contenção de neoliberalismos desenvolvimentistas e movimentos contra-hegemônicos sulistas informados por dinâmicas desocidentalizantes e decoloniais que desafiam-reafirmam estruturas do capitalismo racial. Em uma Era do Desenvolvimento, a RG é rearticulada nos anos 2000 em resposta a hibridismos “irresponsáveis” em países e sociedades emergentes impulsionados por dinâmicas sulistas de aprendizagem-desaprendizagem-reaprendizagem. Este artigo investiga coprodução de relevância sulista do conhecimento no Brasil por meio de cumplicidade subversiva a partir de um nexo organização-escola privilegiado. A análise mostra como gestores e pesquisadores (re) mobilizam teorias-práticas sulistas para coproduzir relevância sob uma perspectiva transformacional-reformista. No final, apresentamos discussões e sugestões para reapropriação coletiva da relevância sulista engajada com o outro em sociedades emergentes/ressurgentes no Sul e Norte.
LINEAR CONVECTIVE STABILITY IN AN INCLINED CHANNEL FILLED WITH A NANOFLUID-SATURATED POROUS MEDIUM
Authors: Srinivasacharya Darbhasayanam , Humnekar Nidhi
Published: February 2023

In this study, convective stability of nanofluid flow in an inclined porous channel is being numerically investigated. The effects of Brownian motion and thermophoresis are accounted for in the nanofluid model. In addition, the flow in the porous region governs Brinkman's equation. A normal mode analysis is used to get the eigenvalue problem for the perturbed state, which is then solved using the Chebyshev spectral collocation approach. The influence of various governing parameters, the critical Rayleigh number, and associated wavenumber are graphically displayed.
Effects of hydrogen sulfide on grass traits and water-gas transport in grass-planted unsaturated soil
Authors: Feng Song , Leung Anthony Kwan , Zhan Liang Tong , Liu Hong Wei , Wang Min , Guo Xing Kai
Published: February 2023

Vegetation has been found to improve the hydrological performance of landfill cover. However, existing studies ignore the effects of hydrogen sulfide (H2S), which forms the toxic odour generated from municipal solid wastes. Hydrogen sulfide is a potential signalling molecule in regulating plant-stomata aperture, but how the plant–hydrogen sulfide interaction affects the water–gas transport in soil remains unknown. This aim of this study was to investigate the effects of hydrogen sulfide on Bermuda grass growth and its influence on water–gas transport in unsaturated soils. Soil columns, with and without vegetation, were prepared and fumigated with different hydrogen sulfide concentrations. These columns were subjected to controlled drought and rainfall sequentially. The results showed that grass leaves almost wilted without hydrogen sulfide fumigation due to the Pythium diseases caused by the antecedent waterlogged conditions. In contrast, hydrogen sulfide fumigation promoted grass growth because of the fungicidal effects of hydrogen sulfide. In drought, hydrogen sulfide fumigation caused stomata closure, which resulted in a lower matric suction in the vegetated soil than that without hydrogen sulfide fumigation. Accordingly, hydrogen sulfide concentration reduced because of oxidation by metal oxides in soil. Upon subsequent rainfall, more infiltration but lower matric suction was observed in vegetated soils than was found in the bare case, whereas hydrogen sulfide concentration decreased continuously due to gas dissolution in the pore water. Direct application of laboratory findings herein to field cases should be used with caution, because the applied continuous lighting and low evapotranspiration rate of the soil column tests may not be representative of field conditions.
Total RNA and DNA from Microalgae (12 samples per microplate) v2
Authors: Hu Ying-Yu
Published: February 2023

Here we describe a protocol for extracting and quantifying bulk RNA and DNA from microalgae, which is adapted from Berdalet E. et al. (2005). RNA and DNA are extracted from microalgae samples and then quantified by fluorochrome SYBR Green II. The level of sensitivity of this method is set at ca. 20 ~300 ng RNA and 10 ~ 100 ng DNA (ml assay)-1.
Quantification of foliar polyphenolic concentration using a 96-well microtitre method v1
Authors: Nickerson Megan
Published: February 2023

Phenolics are secondary metabolites found in various fruits and vegetables. To estimate polyphenol concentrations, the Folin-Ciocalteu (F-C) reagent can be used to react with any reducing agent such as polyphenols, producing a color change that can be measured with spectrophotometry. When known concentrations of phenolics (e.g., tannic acid) are used to create a standard curve, F-C reagent enables estimation of total phenolic concentration. In this protocol, a high-throughput 96-well microtitre plate reader is used rather than a single-sample spectrophotometer. Methods are based on two publications: (1) Attard, E., 2013. "A rapid microtitre plate Folin-Ciocalteu method for the assessment of polyphenols". Open Life Sciences 8, 607; and (2) Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. 2000. "Use of nuclear and related techniques to develop simple tannin assays for predicting and improving the safety and efficiency of feeding ruminants on tanniniferous tree foliage".
The Application of Microalgae Feeding Regime on Whiteleg Shrimp Culture in Each Stage: A Mini Review
Authors: Arsad Sulastri , Siallagan Rubina Melini , Evellin Dewi Lusiana Evellin Dewi Lusiana , Muhammad Musa Muhammad Musa , Mohammad Mahmudi Mohammad Mahmudi , Luthfiana Aprilianita Sari Luthfiana Aprilianita Sari , Fiddy Semba Prasetiya Fiddy Semba Prasetiya , Musa Nadirah
Published: February 2023

Feed management in shrimp culture aims to improve the quality of shrimp organisms. The application of the feeding regime in shrimp culture has been developed to determine the best formulation of diet in order to maximize growth rate and survival rate of shrimp by increasing feed efficiency and minimizing waste. The application of the feeding regime is closely related to the understanding of the physiological and morphological aspects of shrimp from the larval stage to the adult stage. The success of the application of feed management with the application of the feeding regime will be a solution to the problem of the high costs of feed needed in shrimp culture. The best formulation of diet in shrimp culture in the N6-P3 stage is microalgae, at the M1-PL10 stage is zooplankton, and in the juvenile-adult shrimp stage is artificial feed. Microalgae can significantly increase the survival rate and growth rate of shrimp at the hatchery stage. This article aimed to examine the effect of the application of feeding regime using different diet formulations to produce the highest growth performance of shrimp in shrimp culture based on the morphological and physiological aspects of shrimp.
Hyperglycaemia Attenuated C2C12 Myoblast Proliferation and Induced Skeletal Muscle Atrophy via Modulating Myogenic Regulatory Factors Genes Expression in Diabetic Rats
Authors: Tipbunjong Chittipong , Khimmaktong Wipapan , Pholpramool Chumpol , Surinlert Piyaporn
Published: February 2023

Diabetes mellitus is characterised by high blood glucose level termed hyperglycaemia (HG). It has been reported to affect skeletal muscle by inducing skeletal muscle atrophy and skeletal muscle protein degradation leading to impairment of muscle function. This study aimed to investigate the effects of HG on the expression of myogenic regulatory factor genes in muscle progenitor cells and in skeletal muscle. The number of C2C12 myoblasts cultured in HG condition was significantly decreased compared to control in dose and time dependent manner. In addition, the number of Ki-67 positive nuclei was significantly decreased after treatment under HG condition. Real time PCR showed significant suppression of MyoD and myogenin, while Myf5 gene expression was significantly enhanced, compared to control. Furthermore, histological examinations of muscle fibres showed atrophy of tibialis anterior (TA) muscle from diabetic rats. The frequency of distribution of muscle fibre cross-sectional area (MCA) in diabetic rats was shifted leftward from that of normal control rats. In contrast, the MyoD and myogenin expression in TA muscle of diabetic rats were significantly increased compared to normal control rats. This study provides novel knowledge on the changing myogenic regulatory factor gene expression in hyperglycaemic condition, both in vitro and in vivo, leading to skeletal muscle atrophy.
Optimization of Ultrasound-Assisted Extraction for Antioxidant Activity in Relation to Rhoifolin Content of Fortunella polyandra using Response Surface Methodology (RSM)
Authors: Elias Hazim Syahmi , Baharum Syarul Nataqain , Azizan Kamalrul Azlan , Wan Ahmad Wan Yaacob , Chandren Sheela , Basar Norazah
Published: February 2023

Fortunella polyandra (Ridl) Tanaka or Malayan kumquat, is a family of Rutaceae from Malaysia known for its various active compounds, especially flavonoids. This study aims to verify the optimum condition and correlation of leaves extract in Fortunella polyandra by ultrasound-assisted extraction (UAE) for antioxidant activities and apigenin 7-O-neohesperidoside (rhoifolin) contents using the response surface methodology (RSM). Central composite rotatable design (CCD) was performed to investigate the influence of the extraction parameters on maximum antioxidant activity, namely temperatures (X1), times (X2), and solvent ratios of ethanol:water (X3). The optimal extraction conditions for 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were obtained at extraction time of 5 min, temperature of 30 °C and solvent ratio of 70:30, ethanol:water with IC50 value of 0.126±0.004 mg/mL. Rhoifolin content and ferric reducing antioxidant potential (FRAP) assay share the same optimum condition at extraction time of 5 min, temperature of 30 °C, and solvent ratio of 30:70, ethanol:water. Under these conditions, rhoifolin content was measured at 67.83±0.37 ppm, whereas FRAP equivalent value was recorded at 0.22±0.01 mg/mL. All three responses from the model achieved 95% confidence level. Correlation study showed that there is no relationship between the rhoifolin content and the antioxidant activities of Fortunella polyandra extract.
FTIR-Based Metabolomics for Characterization of Antioxidant Activity of Different Parts of Sesbania grandiflora Plant
Authors: Noviany Noviany , Amrulloh M. Hanif , Mohamad Rafi Mohamad Rafi , Bambang Irawan Bambang Irawan , Wisnu Ananta Kusuma Wisnu Ananta Kusuma , Sutopo Hadi Sutopo Hadi , Supriyanto R. , Risa Nofiani Risa Nofiani , Hussin M. Hazwan , Suripto Dwi Yuwono Suripto Dwi Yuwono
Published: February 2023

Sesbania grandiflora, one of the flowering plants with great potential as a source of natural antioxidants because it contains chemicals such as tannin, phenolics, and flavonoids. However, there has been no extensive investigation on the antioxidant activity of isolated from different parts of this plant. This study aims to investigate the correlation between antioxidant activity and secondary metabolites extracted from three different parts (leaves, stem barks, and roots) of S. grandiflora plant using Fourier-transform infrared spectroscopy (FTIR) based metabolomics approach. The FTIR is a very useful technique for identifying the functional groups present in the mixtures, while antioxidant assay provides the base to select the part of the plant as the most potential source of antioxidant. The antioxidant properties were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and potassium ferricyanide reduction method. The multivariate data - analyses using Principal Component Analysis (PCA) and Partial Least Square (PLS) were conducted to compare the distribution of metabolites extracted from different parts of the S. grandiflora plant investigated. The PLS was performed to evaluate the relationship between the components of the extracts obtained from different parts of the plant and their antioxidant activities. The results exhibited that antioxidant activities of the extract of the stem barks, and roots are higher than that of the extract of the leaves. Also, the PLS model indicated that the functional group absorption data were significantly correlated with the IC50 values of antioxidant activity. Subsequently, based on the results of PLS ​​analysis displayed that C=C, C=O, and along with C-O functional groups are proposed as the main contributors to the antioxidant activity of the extracts tested. The extracts of different parts were grouped using PCA analysis with a total of principal components (PC) of 94%.
Evaluation of Xylose-Utilising Yeasts for Xylitol Production from Second-Generation Ethanol Vinasse and Effect of Agitation Intensity in Flask-Scale Xylitol Production
Authors: Hor Sreyden , Kongkeitkajorn Mallika Boonmee , Reungsang Alissara
Published: February 2023

This study aimed to select a yeast strain that effectively utilises xylose to produce xylitol from the vinasse of ethanol broth obtained from the fermentation of sugarcane bagasse hydrolysate. Eleven strains of xylose-fermenting yeasts were evaluated for their abilities to utilise xylose and produce xylitol. Two strains that showed outstanding performance in the semi-defined xylose medium were selected for further testing with a vinasse medium. Candida guilliermondii TISTR 5068 showed a superior xylitol production of 7.03 ± 0.08 g/L with the xylitol yield of 0.70 g/gxylose when cultured in bagasse-based ethanol vinasse. The strain was further tested for its xylitol production performance when cultured at four different agitation intensities. Excessive agitation resulted in a rapid xylitol production rate but caused xylitol consumption once the xylose was depleted. Moderate agitation resulted in the highest xylitol yield of 0.79 g/gxylose. The results of this study have provided important information for the development of the xylitol production process using waste streams from cellulosic ethanol production.
A New Exponentiated Beta Burr Type X Distribution: Model, Theory, and Applications
Authors: Oh Yit Leng , Lim Fong Peng , Chen Chuei Yee , Ling Wendy Shinyie , Loh Yue Fang
Published: February 2023

In recent years, many attempts have been carried out to develop the Burr type X distribution, which is widely used in fitting lifetime data. These extended Burr type X distributions can model the hazard function in decreasing, increasing and bathtub shapes, except for unimodal. Hence, this paper aims to introduce a new continuous distribution, namely exponentiated beta Burr type X distribution, which provides greater flexibility in order to overcome the deficiency of the existing extended Burr type X distributions. We first present its density and cumulative function expressions. It is then followed by the mathematical properties of this new distribution, which include its limit behaviour, quantile function, moment, moment generating function, and order statistics. We use maximum likelihood approach to estimate the parameters and their performance is assessed via a simulation study with varying parameter values and sample sizes. Lastly, we use two real data sets to illustrate the performance and flexibility of the proposed distribution. The results show that the proposed distribution gives better fits in modelling lifetime data compared to its sub-models and some extended Burr type X distributions. Besides, it is very competitive and can be used as an alternative model to some nonnested models. In summary, the proposed distribution is very flexible and able to model various shaped hazard functions, including the increasing, decreasing, bathtub, and unimodal.
Correction of the Values of the Classification Feature of Objects on the Example of the Diagnosis of Multiple Myeloma
Authors:   National University of Uzbekistan, Tashkent, Uzbekistan, Ignatev N. A. , Zguralskaya E. N. ,   Ulyanovsk State Technical University, Ulyanovsk, Russian Federation, Markovtseva M. V. ,   Ulyanovsk State University, Ulyanovsk, Russian Federation
Published: February 2023

The clinical features of changes in multiple myeloma indicators of different types associated with the gender of patients (objects) are considered. The methods of data mining examine the truth of the statement about the presence of many patients for whom gender is not significant in making a diagnosis. It is proposed to use the preprocessing of heterogeneous data to unify the description of objects in the binary space. The conditions for selecting and removing noise features from the set are determined. In order to reduce the dimensionality of the space, latent features are calculated by groups of binary generalized estimates of objects. A criterion is proposed for dividing patients into the optimal number of groups, taking into account their gender authenticity. From these groups, a new classification of objects is formed, differentiated by gender. The formation process is illustrated through the visualization of object descriptions, recognition accuracy and selection of informative feature sets according to the new classification. The selection procedure is implemented according to the rules of a hierarchical agglomerative algorithm. The property of invariance to the measurement scales of quantitative traits is an important argument for using the obtained results on data samples from the general population.
Building an Optimal Convolutional Neural Network Model for Solving Complex Character Recognition Problems
Authors:   Synergy University, Moscow, Russian Federation, Trubin A. E. , Batishchev A. V. ,   Synergy University, Moscow, Russian Federation, Aleksahin A. N. ,   Synergy University, Moscow, Russian Federation, Zubanova A. E. ,   Orel State University named after I. S. Turgenev, Orel, Russian Federation, Morozov A. A. ,   Orel State University named after I. S. Turgenev, Orel, Russian Federation
Published: February 2023

The purpose of the study is aimed at developing a lighter architecture of a convolutional neural network model that will cope with the narrowly focused task of recognizing complex characters better than large-scale and well-known ones. As the source data, the characters of the Japanese language are used, consisting of two syllabic alphabets: hiragana and katakana, which are the most complex, since their writing style is characterized by a large number of features and similarity of characters, which greatly complicates the task of their classification and recognition. The author's model of a convolutional neural network is designed in the article, consisting of four convolutional layers, three layers of subdiscretization and three layers of exclusion. The developed model was compared with one of the most popular models of the EfficientNetBO neural network from the point of view of their architecture and the results of work on the same data. To implement its own convolutional neural network model, the classic Keras + Tensorflow bundle was used, since these libraries provide the most convenient tools for working in the field of machine learning. The result of the conducted research is the developed technology of fast and accurate recognition of complex symbols based on a convolutional neural network, which can become the basis of a software product in the field of computer vision.
AMD-Xilinx Kria as a Basis for Industrial Equipment Embedded Control System
Authors:   Bigprinter Digital Innovations, LLC, Odintsovo, Moscow Region, 143002, Russian Federation, Popov M. A. , Mashkovskaya M. S. ,   Bigprinter Digital Innovations, LLC, Odintsovo, Moscow Region, 143002, Russian Federation, Romanov A. Yu. ,   National Research University Higher School of Economics, Moscow, 109028, Russian Federation
Published: February 2023

This article presents a promising embedded control system designed to implement highly complex algorithms in industrial equipment that requires multi-axis positioning and high-speed data transmission. Brief information about the current trends in the development of the user interface of industrial equipment is given, the relevance of control systems with a graphical interface and support for touch displays is noted. The characteristics of the previously developed control system (based on the Zynq-7000 chip) are given, the shortcomings of this system are noted. The use of the Kria SOM module, developed by AMD-Xilinx (USA), is proposed. The key functional blocks of the control system are indicated, the structure of the embedded software is briefly shown. A comparison of two variants of the system — based on Zynq-7000 and Kria SOM — is made. The conclusion about the advantages of using the Kria SOM module (namely: the increase in the speed of mathematical calculations up to 5 times — depending on the task, decrease in the cost of components up to 10 times, simplification of the design of a printed circuit board by reducing the number of layers from 14—16 to 10, significant reduction in time cost of developing a circuit diagram and printed circuit board) is made. The advantages of the Kria SOM as the basis for building a control system with artificial intelligence capabilities are noted.
Gombrich, Ukraine and another Science of Art
Authors:   Taras Shevchenko national University of Kyiv, Demchuck Stefaniia
Published: February 2023

The essay discusses the state and the prospects of Ukrainian art history and its relationship with the so-called ‘Art studies’. It offers insights into the origins of the notion of art studies imposed by the Soviet authorities to replace the ‘bourgeois’ theory and history of art which flourished at the beginning of the 20th century in Ukrainian universities. The introduction of art studies meant the growth of the rift between Soviet scholarship and the rest of the world. This first shift was followed by acts aimed at provincializing Ukrainian scholars through censorship and limited access to publications and fellowships. The long-awaited independence of Ukraine has changed much neither in approaches to teaching the history of art at art schools and academies nor in the methodology of scholars. The science of art in Ukraine remains to a large extent outdated, rooted in connoisseurship and formal analysis and sometimes even confused with art criticism. Ernst Gombrich’s lecture of 1966 pointed to the importance of tackling political, social and economic circumstances that impacted artistic development while teaching art history. His conclusions despite seeming obvious are still to be taken into account in Ukrainian realities as the attitude towards history in art academies remains rather superficial and condescending as to a ‘science of facts’, which completely ignores the last decades of methodological pursuits of historians and art historians. Going back to the notion of theory and history of art as a discipline that should be taught and researched as well as tackling linguistic obstacles and re-inventing methodology might help to overcome the divide between Ukrainian scholarship and their foreign peers and make research conducted in Ukraine and/or by Ukrainian art historians visible to the European and global art community. It, too, will mean the beginning of another science of art in Ukraine.
Unhappy Emotions in the Miniatures and the Text of the Radzyvill Chronicle
Authors:   Vernadsky National Library of Ukraine, Petrushko Liudmyla
Published: February 2023

The article examines the miniatures of the Radzyvill Chronicle. It attempts to discriminate between real and fictional emotions of a person from the Middle Ages and focuses on the expressions of sorrow and crying. In historical studies of emotions, images are crucial. They record both real manifestations of emotions and ideas about their importance, expediency, essence. The article relies upon iconographic method, as well as upon semiotics, historical-comparative and content analysis. We assume that sad emotions have more expressiveness in the visual manifestations. Reading facial expressions in miniatures or painting can be challenging. Thus, we rely on interpreting a hand near the cheek or the hem of a garment pressed to the face or sleeves that are down as a universally recognized gesture of sadness. This paper offers a first insight into the miniatures of the Radzivil Chronicle, which depict sadness and crying. It examines emotions through narrative and visual strategies of the Chronicle and reveals how it fits within the tradition of showing tears and sadness in medieval society. After studying the Chronicle, we can conclude that it did not deal with emotions extensively. Only 25 of the 613 miniatures of the Königsberg list (which is 4% of all images) convey unhappy emotions. The miniatures from the Radzyvill chronicle confirm the three main states where sadness and weeping corresponded with the decorum of medieval Rus: the death of loved ones, common misfortunes or public troubles like captivity and separation-farewell. Therefore, the emotions depicted in the Chronicle were historically conditioned. Sadness was conveyed in illuminations that dealt with the departure from this world and burials of princes and clerics, the military conflicts, which affected people’s lives. Sometimes the emotions were not mentioned in the accompanying text, but only conveyed through the visual means, which reveals medieval behavioral models and ideas about crying as a natural emotional reaction to the death and burial of the loved ones and to the misfortunes associated with captivity. The absence of illustrations of sadness and tears in the Pechersk cycle of miniatures is generally consistent with the tradition of illustrating texts where attention was paid to actions and not to emotions. This fact, too, may indicate the understanding of tears of repentance and prayer as an internal state that is not conveyed through external means.
Development of a verified osteoarthritis risk scale based on a cross-sectional study of clinical and anamnestic parameters and pharmacological anamnesis of patients
Authors: Torshin I. Yu. , Lila А. М. , Zagorodniy N. V. , Nazarenko А. G. , Tkacheva О. N. , Dudinskaya Е. N. , Alekseeva L. I. , Taskina Е. А. , Sarvilina I. V. , Shavlovskaya О. А. , Danilov A. B. , Minasov Т. B. , Galustyan А. N. , Malyavskaya S. I. , Gromov А. N. , Egorova Е. Yu. , Vasilyeva L. V. , Evstratova E. F. , Gogoleva I. V. , Fedotova L. E. , Udovika М. I. , Maximov V. A. , Povzun А. S. , Gromova О. А.
Published: February 2023

Objective: the development and verification of a scale for identifying patients at high risk of osteoarthritis (OA).

Material and methods. The results of the analysis of a sample of patients aged 35–90 years from the database of the Institute of Trace Elements (n=3440), which included information on clinical and anamnestic, diagnostic parameters and pharmacotherapy of patients, including patients with OA (n=107), are presented. To analyze information about patients, modern methods of data analysis proposed within the topological theory of pattern recognition were used.

Results. Based on the analysis of the sample, a 100-point scale of 27 points was developed which allows to identify patients at high risk of OA (sensitivity 88%, specificity 100%). For patients with high scores on the scale, a kind of “preemptive” prescription of symptomatic slowacting drugs for osteoarthritis (SySADOA) based on highly purified substances of chondroitin sulfate (CS) and glucosamine sulfate (GS) is promising. The evidence for CS/GS is extensive and has been reviewed previously.

Conclusion. Early adoption of preventive measures (including the usage of SySADOA – CS/GS) in patients with a high score on the developed scale may reduce the risk of OA.
Digital maturity as an indicator of the success of the university’s digital transformation
Authors: Ershova I. V. , Enkova E. E.
Published: February 2023

The article highlights the problems of achieving digital maturity by higher education organizations. The relationship between the categories “digital transformation” and “digital maturity” is shown. An overview of methods for determining the level of digital maturity of organizations is presented. It is argued that digital transformation is associated with a clear understanding of the goals of any digital transformation and the ability to assess the effectiveness of changes. On the example of the Kutafin University (MSAL), the experience of digital transformation of the university is comprehended. It is shown how, through the adoption of local regulations and the formation of an innovative infrastructure, the transition from digital literacy to digital maturity is being made in MSAL. It is emphasized that in order to carry out successful digitalization, it is necessary to implement a set of interrelated measures, such as the introduction of advanced information and telecommunications technologies, the development of digital infrastructure, the revision of approaches to education management, the change of higher school employees themselves. Based on a sociological study, the degree of awareness of students about the normative consolidation of the category “digital maturity”, its content and scope of application was revealed.
Legal regime of economic activity of non-profit organizations
Authors: Svit Yu. P. , Shcherbakova M. A.
Published: February 2023

The article discusses the features of the legal regime of economic activity of non-profit organizations. It is proved that the legal regime of economic activity is determined by the peculiarities of the legal status and legal personality of non.
State support for startups for the creation and development of small businesses in agribusiness: problems of legal regulation
Authors: Elnikova Е. V.
Published: February 2023

The analysis of the regulatory legal regulation of the Agrostartap grant at the federal and regional levels is carried out. The problem of complicating access to state support for grantees due to the inclusion of additional requirements not provided for at the federal level in the regional rules for the provision of grants has been identified. The features of startups in the field of agribusiness are determined. The main conditions for granting the Agrostartap grant are considered. The stimulating nature of grants in the form of subsidies to support startups in the field of agribusiness has been established. The practice of Russian courts on disputes from grant agreements has been studied and presented. The conclusion is formulated about the civil nature of relations related to the provision of state support in the form of grants to agricultural producers, as well as their complex legal regulation by the norms of civil and budgetary legislation.
Legal regulation of the procedure for providing restricted access information contained in government information systems to third parties: the experience of foreign countries
Authors: Izhaev O. А. , Kuteynikov D. L.
Published: February 2023

The article is devoted to the research of foreign experience of the legal regulation of the procedure of providing restricted access information contained in state information systems to third parties.It is pointed out that in the European Union the law prohibits the disclosure of confidential information contained in the information system for monitoring the circulation of goods. In addition, in the EU it is not allowed to provide commercial services to third parties on the basis of data collected in the system from participants in the circulation of such goods According to the U. S. approach, information from government databases may be transferred to third parties at fixed tariffs, but this information must not be confidential. In the Republic of Turkey the legislation does not provide for the possibility of transferring restricted access information to third parties.It is shown that the legal approaches of the Republic of Kazakhstan and the Republic of Uzbekistan have a similarity. The legal acts of both countries regulating the functioning of certain government information systems do not provide for the possibility of transferring restricted access information to third parties from them. Regarding the Republic of Belarus, it is concluded that in this country restricted access information from government information systems cannot be provided to third parties on the basis of the provisions of the legislation.
Digital rights in the russian financial system: legal aspect
Authors: Lubyagina D. V. , Akhrem T. P.
Published: February 2023

In the program of studying the disciplines “Investment Law”, “Civil Law”, “Business Law” and a number of other disciplines, the issue of digital rights, a clear definition of their legal status in the system of objects of rights, the distinction between different types of digital rights, etc., is currently becoming a significant issue for study. This is especially important, given the tendency to increase the digitalization of economic turnover and, accordingly, the adaptation of the legal system, as well as those problems of legal regulation that are associated with a very large uncertainty and different approaches to determining the status of digital rights and their types. It is extremely difficult for students to understand a huge number of different, sometimes contradictory points of view. We have made an attempt to bring some clarity to this issue, taking into account the author’s position.The article analyzes the issue of the differentiation of certain types of digital rights, the differentiation of digital financial assets and digital utilitarian rights from non-documentary securities, certain aspects of the regulation of such financial instruments in foreign legal systems, the current use and the possibility of using these financial instruments on investment platforms not only as a means of investing in the future.
DETERMINANTS OF ENTREPRENEURIAL DYNAMICS: THE CASE OF THE EUROPEAN UNION
Authors: Stanković Jelena J. , Marjanović Ivana , Milanović Sandra , Jovanović Vujatović Milica
Published: February 2023

Since economic theory identifies new enterprises as one of the basic drivers of economic growth, it brings to the forefront the need to understand the existing dynamics of entrepreneurship. Consequently, the identification of the basic entrepreneurship’s determinants is a central issue from both a theoretical and a practical point of view in contemporary literature. A better understanding of the factors influencing the dynamics of entrepreneurship is a basic precondition for creating effective policies aimed at encouraging the creation of new companies, and consequently, the creation of new jobs. Therefore, this paper addresses several important issues. From the theoretical standpoint, the role of entrepreneurial determinants in creating a new business is examined. From a practical standpoint, the basic formal institutional factors influencing the birth rate of new companies are analyzed. The analysis was conducted on a sample of European Union countries for the period from 2010 to 2019 using data from the World Bank’s Doing Business database, as well as data on business dynamics from the Eurostat database. A panel data regression analysis using the fixed-effects estimation procedure with Driscoll-Kraay standard errors was conducted, and the results indicate that the dynamics of new enterprises’ foundation are negatively affected by the total tax burden, as well as the cost of property registration, while the amount of initial capital required to open a business has a positive impact. The results of the research can serve as a basis for fine-tuning policies that will facilitate and encourage the creation of new enterprises.
THE IMPACT OF WORKING CAPITAL MANAGEMENT ON SME PROFITABILITY – EVIDENCE FROM KOSOVO
Authors: Ahmeti Ardi , Ahmeti Yllka , Ahmeti Skender
Published: February 2023

The study attempts to show the impact of working capital management on the profitability of ninety-eight Kosovo-based SMEs, primarily in the manufacturing and construction sectors. The data were obtained from the financial statements of these companies for the years 2010 through 2020, and the assumptions were verified using the Ordinary least square (OLS) method. To express SMEs profitability, return on assets (ROA) is taken as a dependent variable, while to express working capital management, independent variables are taken: the inventory turnover period (INTP), receivables collection period (TRCP), trade payable period (TPP), and cash conversion cycle (CCC). In addition, are taken four control variables (size of companies, current ratio, sustainable growth, and leverage), which are not a variable of interest in the study but could influence the outcomes. The results reveal that SMEs increase profitability by decreasing the cash INTP and increasing TRCP, TPP, and CCC. By analyzing the effect of working capital management on profitability in the context of SMEs in Kosovo, this research contributes new knowledge to the existing literature.
A tudatos jelenlét alapú beavatkozások hatásai a stroke utáni rehabilitációban
Authors: Udvardi Veronika , Szabó Gábor , Fazekas Gábor
Published: February 2023

A stroke napjainkban az egyik leggyakoribb, súlyos fogyatékosságot okozó betegség világszerte, ami a mozgásszervi károsodáson túlmenően olyan hangulati és kognitív változásokkal járhat, amelyek jelentősen kihatnak a beteg életminőségére. A folyamatosan zajló kutatásoknak köszönhetően egyre több terápiás eszköz és lehetőség segíti a károsodott funkciók helyreállítását. A tudatos jelenlét alapú technikák számos kórképben bizonyítottan csökkentik a stressz-szintet, és segítik a krónikus betegségekkel való megküzdést. Az eddigi kutatási eredmények alapján a tudatos jelenlét alapú beavatkozások pozitív változásokat idéznek elő a stroke-kal együtt járó hangulatzavarok, mentális fáradtság, valamint egyes kognitív és fizikai funkciók terén, miközben fokozzák a jóllétet, és ígéretes lehetőséget jelentenek a szekunder prevencióban is. A 2000-es évek elejétől számos kutatást végeztek a tudatos jelenlét alapú beavatkozások hatékonyságának felmérésére a stroke utáni rehabilitációban, folyamatosan fejlődő kezelési protokollokkal. A jelen tanulmányban összefoglalót kívánunk nyújtani e nemzetközi kutatások fontosabb eredményeiről, és bemutatjuk a tudatos jelenlét alapú technikák módszertanát. Elsődleges célunk, hogy az eredményeket értékelve felhívjuk a figyelmet a téma fontosságára; reményeink szerint az elméleti és gyakorlati ismereteket tartalmazó összefoglalónk hozzájárul a kutatásokban hatásosan és biztonságosan alkalmazható protokollok kifejlesztéséhez. A tudatos jelenlét alapú programok klinikailag releváns, kiegészítő terápiás eljárássá válhatnak a stroke utáni rehabilitációban, azonban alkalmazhatóságuk és hatékonyságuk pontosítására nagy volumenű randomizált, kontrollált, utánkövetéses vizsgálatok szükségesek, egyéb élettani paraméterekre kifejtett hatásaik felmérésével, a hatásmechanizmusban szereplő köztes tényezők feltérképezésével és a különböző kezelési helyzetekre kidolgozott egységes és optimalizált tréningprotokollok alkalmazásával.