bluuebunny/crossref_metadata_2025 huggingface dataset:
Apatinib manifests an unexpectedly favorable outcome in the management of axillary lymph node follicular dendritic cell sarcoma: a case report
Authors: Feng Zhiying , Du Zhonghai , Liang Yan , Zhou Juyue
Published: June 2024

We present a case of follicular dendritic cell sarcoma in the axillary lymph node, which unexpectedly showed favorable outcomes after the application of apatinib. Follicular Dendritic Cell Sarcoma (FDCS) exhibits a rare incidence and an unclear pathogenic mechanism, contributing to the limited breakthroughs in its treatment to date within the medical field. The current mainstream therapeutic approaches include surgery, CHOP(cyclophosphamide, doxorubicin, vincristine, prednisone), ICE(ifosfamide, carboplatin, etoposide), ABVD(doxorubicin, bleomycin, vinblastine, dacarbazine), and immune checkpoint inhibitors. A 38-year-old male patient was admitted to the hospital due to a lump in the right axilla and underwent surgical treatment. Postoperative pathology confirmed the diagnosis of follicular dendritic cell sarcoma. Two months post-surgery, he faced a recurrence, prompting a subsequent surgical intervention complemented by tumor radiofrequency ablation. Despite these interventions, the treatment response was suboptimal. Subsequently, the patient was treated with the CHOP regimen, but after two cycles, he developed bone metastasis. Due to the patient's limited financial resources and refusal of immunotherapy, we switched to a regimen of gemcitabine and docetaxel, but the disease progressed again after two cycles. A one-cycle trial of albumin-bound paclitaxel yielded unsatisfactory results. Ultimately, the patient was treated with Apatinib, achieving a 10-month progression-free survival. Due to the patient's limited financial circumstances, we, in the absence of guideline recommendations and evidence from evidence-based medicine, achieved a 10-month progression-free survival (PFS) solely based on experiential use of the anti-angiogenic drug, Apatinib. The purpose of this case report is to provide additional therapeutic options for FDCS treatment and to pave the way for exploring the mechanism of action of Apatinib in FDCS.
Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells
Authors: Qu Minmin , Chen Jia , Xu Bin , Shi Qinyun , Zhao Shujing , Wang Zhaoxia , Li Zhi , Ma Bo , Xu Hua , Ye Qinong , Xie Jianwei
Published: June 2024

Chemotherapy has already proven widely effective in treating cancer. Chemotherapeutic agents usually include DNA damaging agents and non-DNA damaging agents. Assessing genotoxic effect is significant during chemotherapy drug development, since the ability to attack DNA is the major concern for DNA damaging agents which relates to the therapeutic effect, meanwhile genotoxicity should also be evaluated for chemotherapy agents’ safety especially for non-DNA damaging agents. However, currently applicability of in vitro genotoxicity assays is hampered by the fact that genotoxicity results have comparatively high false positive rates. γ-H2AX has been shown to be a bifunctional biomarker reflecting both DNA damage response and repair. Previously, we developed an in vitro genotoxicity assay based on γ-H2AX quantification using mass spectrometry. Here, we employed the assay to quantitatively assess the genotoxic effects of 34 classic chemotherapy agents in HepG2 cells. Results demonstrated that the evaluation of cellular γ-H2AX could be an effective approach to screen and distinguish types of action of different classes of chemotherapy agents. In addition, two crucial indexes of DNA repair kinetic curve, i.e., k (speed of γ-H2AX descending) and t50 (time required for γ-H2AX to drop to half of the maximum value) estimated by our developed online tools were employed to further evaluate nine representative chemotherapy agents, which showed a close association with therapeutic index or carcinogenic level. The present study demonstrated that mass spectrometric quantification of γ-H2AX may be an appropriate tool to preliminarily evaluate genotoxic effects of chemotherapy agents.
Branched-chain amino acids and L-alanine supplementation ameliorate calcium dyshomeostasis in sarcopenia: New insights for nutritional interventions
Authors: Conte Elena , Mantuano Paola , Boccanegra Brigida , Imbrici Paola , Dinoi Giorgia , Lenti Roberta , Cappellari Ornella , Cappetta Donato , De Angelis Antonella , Berrino Liberato , Gordish-Dressman Heather , Bianchini Gianluca , Aramini Andrea , Allegretti Marcello , Liantonio Antonella , De Luca Annamaria
Published: June 2024

Introduction: During aging, sarcopenia and decline in physiological processes lead to partial loss of muscle strength, atrophy, and increased fatigability. Muscle changes may be related to a reduced intake of essential amino acids playing a role in proteostasis. We have recently shown that branched-chain amino acid (BCAA) supplements improve atrophy and weakness in models of muscle disuse and aging. Considering the key roles that the alteration of Ca2+-related homeostasis and store-operated calcium entry (SOCE) play in several muscle dysfunctions, this study has been aimed at gaining insight into the potential ability of BCAA-based dietary formulations in aged mice on various players of Ca2+ dyshomeostasis.

Methods: Seventeen-month-old male C57BL/6J mice received a 12-week supplementation with BCAAs alone or boosted with two equivalents of L-alanine (2-Ala) or with dipeptide L-alanyl-L-alanine (Di-Ala) in drinking water. Outcomes were evaluated on ex vivo skeletal muscles indices vs. adult 3-month-old male C57BL/6J mice.

Results: Ca2+ imaging confirmed a decrease in SOCE and an increase of resting Ca2+ concentration in aged vs. adult mice without alteration in the canonical components of SOCE. Aged muscles vs. adult muscles were characterized by a decrease in the expression of ryanodine receptor 1 (RyR1), the Sarco-Endoplasmic Reticulum Calcium ATPase (SERCA) pump, and sarcalumenin together with an alteration of the expression of mitsugumin 29 and mitsugumin 53, two recently recognized players in the SOCE mechanism. BCAAs, particularly the formulation BCAAs+2-Ala, were able to ameliorate all these alterations.

Discussion: These results provide evidence that Ca2+ homeostasis dysfunction plays a role in the functional deficit observed in aged muscle and supports the interest of dietary BCAA supplementation in counteracting sarcopenia-related SOCE dysregulation.
Honokiol as an α-glucosidase inhibitor
Authors: Zhu Hua , Zhong Xin
Published: June 2024

Honokiol, a naturally occurring compound from Magnolia obovata Thunb., has many biological activities, but its anti-α-glucosidase activity is still unclear. Therefore, we determined its inhibitory effects against α-glucosidase. Activity assays showed that honokiol was a reversible mixed-type inhibitor of α-glucosidase, and its IC50 value was 317.11 ± 12.86 μM. Fluorescence results indicated that the binding of honokiol to α-glucosidase caused a reduction in α-glucosidase activity. 3D fluorescence and CD spectra results indicated that the binding of honokiol to α-glucosidase caused conformational change in α-glucosidase. Docking simulated the detailed interactions between honokiol and α-glucosidase, including hydrogen and hydrophobic bonds. All findings showed that honokiol could be used as a natural inhibitor to develop α-glucosidase agents.
Photobiomodulation (PBM): a therapeutic technique targeting fibroblast cell regeneration and survival in diabetic wounds
Authors: Jere Sandy Winfield , Houreld Nicolette Nadene
Published: June 2024

In injury, fibroblasts are key for disintegrating the fibrin clot, secreting collagen proteins, and constructing extracellular matrix Altered fibroblast function is among the common characteristics of delayed wound healing and development of chronic wounds. Thus, treatment methods for effective wound healing require agents that affect the complexed wound milieu, including fibroblast cells. Diabetes mellitus (DM) is a common cause of impaired fibroblast cell function, delayed wound healing, development of chronic ulcers, and limb amputation. Photobiomodulation (PBM) promotes fibroblast cell proliferation, migration, release of growth factors and wound healing. Yet, its use is limited largely due to an incomplete understanding of its underlying mechanisms at the molecular and cellular level. In this review, we summarise the involvement of fibroblast cells in wound healing, and the effect of PBM on fibroblast cell function and diabetic wound healing. PubMed, Google Scholar, and Research Gate were used to find pertinent academic articles.
Pre-exercise cryotherapy reduces myoglobin and creatine kinase levels after eccentric muscle stress in young women
Authors: Kusmierczyk Justyna , Wiecek Magdalena , Bawelski Marek , Szygula Zbigniew , Rafa-Zablocka Katarzyna , Kantorowicz Malgorzata , Szymura Jadwiga
Published: June 2024

Introduction: The aim of this study was to investigate the effect of pre-exercise whole-body cryotherapy (WBC) on muscle damage indicators following eccentric treadmill exercise in young women.

Methods: Twenty-seven participants underwent two 1-h downhill treadmill runs, replicating 60% of their maximal oxygen uptake, with a 4-week intermission for recovery and treatment application. In this intermission, one group underwent 20 sessions of WBC, delivered five times a week at −120°C for 3 min each, while the comparison group received no such treatment. Markers of muscle injury—serum myoglobin concentration, creatine kinase and lactate dehydrogenase activity and also uric acid, and cell-free DNA concentration—were measured before and after downhill runs.

Results: The study observed a notable reduction in post-exercise myoglobin and CK levels in the WBC group after the second running session.

Discussion: The results suggest that WBC can have a protective effects against muscle damage resulting from eccentric exercise.
Identity preserved plant molecular farming offers value-added opportunity for farmers
Authors: Kunkler Kyle , Gerlt Scott
Published: June 2024

Bulk commodity row crop production in the United States is frequently subject to narrow profit margins, often complicated by weather, supply chains, trade, and other factors. Farmers seeking to increase profits and hedge against market volatility often seek to diversify their operations, including producing more lucrative or productive crop varieties. Recombinant plants producing animal or other non-native proteins (commonly referred to as plant molecular farming) present a value-added opportunity for row crop farmers. However, these crops must be produced under robust identity preserved systems to prevent comingling with bulk commodities to maintain the value for farmers, mitigate against market disruptions, and minimize any potential food, feed, or environmental risks.
Generative preparation tasks in digital collaborative learning: actor and partner effects of constructive preparation activities on deep comprehension
Authors: Mende Stephan , Proske Antje , Narciss Susanne
Published: June 2024

Deep learning from collaboration occurs if the learner enacts interactive activities in the sense of leveraging the knowledge externalized by co-learners as resource for own inferencing processes and if these interactive activities in turn promote the learner's deep comprehension outcomes. This experimental study investigates whether inducing dyad members to enact constructive preparation activities can promote deep learning from subsequent collaboration while examining prior knowledge as moderator. In a digital collaborative learning environment, 122 non-expert university students assigned to 61 dyads studied a text about the human circulatory system and then prepared individually for collaboration according to their experimental conditions: the preparation tasks varied across dyads with respect to their generativity, that is, the degree to which they required the learners to enact constructive activities (note-taking, compare-contrast, or explanation). After externalizing their answer to the task, learners in all conditions inspected their partner's externalization and then jointly discussed their text understanding via chat. Results showed that more rather than less generative tasks fostered constructive preparation but not interactive collaboration activities or deep comprehension outcomes. Moderated mediation analyses considering actor and partner effects indicated the indirect effects of constructive preparation activities on deep comprehension outcomes via interactive activities to depend on prior knowledge: when own prior knowledge was relatively low, self-performed but not partner-performed constructive preparation activities were beneficial. When own prior knowledge was relatively high, partner-performed constructive preparation activities were conducive while one's own were ineffective or even detrimental. Given these differential effects, suggestions are made for optimizing the instructional design around generative preparation tasks to streamline the effectiveness of constructive preparation activities for deep learning from digital collaboration.
The effect of a collective competence intervention on collective efficacy, psychological wellbeing, and social wellbeing: a quasi-experimental study of a sample of healthcare workers during the COVID-19 crisis
Authors: Campos María Lourdes , Bolgeri Pedro , Bascur Axel
Published: June 2024

Background

The health crisis associated with COVID-19 led to a period of increased demand on the operational and social organization of healthcare centers, which often had a negative impact on the psychological and social wellbeing of healthcare workers. In order to tackle this issue, an intervention plan was designed to develop collective competences through various participatory strategies. This study sought to determine the effect of this intervention on the variables collective efficacy, psychological wellbeing, and social wellbeing in healthcare workers by performing a pretest and posttest comparison with a control group.

Method

The variables were evaluated using a non-probability, purposive sample of 80 healthcare workers from three Family Healthcare Centers (CESFAM) located in the Coquimbo Region, Chile, within health crisis context. The intervention group was composed of voluntary participants, while the control group only completed the evaluations. The intervention consisted in 6 training workshops focused on improving collective management, group synergy, collaborative problem-solving, communicative strategies, and overall team care.

Results

The analysis shows that the collective competence intervention had a positive effect on the collective efficacy, psychological wellbeing, and social wellbeing of the participating healthcare workers during the COVID-19 crisis. Only specific factors of these variables did not undergo a significant impact.

Conclusion

The results of this study suggest that interventions aimed at improving collective organizational competences, apart from increasing collective efficacy, can have a positive impact on healthcare workers' psychological and social wellbeing in a context of occupational adversity.
Cultivating insight and engagement: exploring the role of Trait Emotional Intelligence in Chinese art education
Authors: Wang Cong
Published: June 2024

Background

The present study focuses on the unique role of insight and Trait Emotional Intelligence in the realm of art education in China. Insight, traditionally associated with clinical outcomes such as mastering symptoms, developing adaptive behaviors, and enhancing quality of life, is newly contextualized in this study within the framework of art education. The expansion of insight research into areas like Social Psychology reflects its relevance beyond clinical settings, particularly in educational environments where creativity and emotional intelligence are pivotal.

Aim

In Chinese art education, insight is crucial not just for personal growth but also for professional development, integrating the understanding of emotions, culture, and artistic expression. This study explores how Trait Emotional Intelligence fosters insight and engagement in art students, underscoring its transformative impact on their educational and professional journey in the art world.

Methods

Using a sample of Chinese art education students at University level (N = 881), that answered a quantitative self-report questionnaire, statistical procedures are applied to test the relationships between Trait Emotional Intelligence, Insight orientation, and students’ academic engagement.

Results

In the structural model, the path from Trait Emotional Intelligence to Insight Orientation was significant, indicating a positive relationship. Students’ Engagement was significantly predicted by Insight Orientation and Trait Emotional Intelligence.

Implications

This finding corroborates theoretical assertions that individuals with higher emotional intelligence are more inclined to have enhanced insight. The findings of the present study extend beyond the field of Art education, allowing us to provide a broad spectrum of social implications for Higher Education institutions.
Beyond sound irritation: cross-cultural evidence on the robustness of the five aspects of misophonic experience measured by the S-Five in a Polish sample
Authors: Uglik-Marucha Nora , Siepsiak Marta , Zielińska Julia , Dragan Wojciech Łukasz , Gregory Jane , Vitoratou Silia
Published: June 2024

Misophonia is commonly associated with negative emotional or physiological responses to specific sounds. However, the consensus definition emphasizes that misophonia entails much more than that. Even in cases of subclinical misophonia, where individuals do not meet the disorder criteria, the experience can still be burdensome, despite not currently causing significant distress or impairment. The S-Five is a psychometric tool for comprehensive assessment of five aspects of misophonic experience: internalizing, externalizing, impact, threat, and outburst, and includes S-Five-T section to evaluate feelings evoked by triggering sounds and their intensity. We examined whether the five-factor structure developed in the UK could be replicated in a Polish sample, including individuals with and without self-identified misophonia. The Polish version of the S-Five was translated and tested on 288 Polish-speaking individuals. Comprehensive psychometric evaluation, including factor structure, measurement invariance, test–retest reliability, internal consistency, and concurrent validity evaluations, was conducted on the translated scale. Exploratory factor analysis suggested similar structure to the original English study, while bootstrap exploratory graph analysis showed the factor structure to be reproducible in other samples. The scale was found to be bias free with respect to gender, internally consistent and stable in time, and evidence of validity was provided using MisoQuest and Misophonia Questionnaire. These results offer support for the cross-cultural stability of the five factors and provide preliminary evidence for the suitability of the Polish version for clinical and research purposes. The study also investigated five facets of misophonia, triggering sounds, emotional responses, and their associations with symptoms of psychopathology across various cultures. It underscores the central role of anger, distress, and panic, while also highlighting the mixed role of irritation and disgust in misophonia across different cultural contexts. Mouth sounds evoked the most pronounced reactions compared to other repetitive sounds, although there were discernible cultural differences in the nature and intensity of reactions to various trigger sounds. These findings hold significant implications for future research and underscore the importance of considering cultural nuances in both research and the clinical management of misophonia.
The Safe Sport Allies bystander training: developing a multi-layered program for youth sport participants and their coaches to prevent harassment and abuse in local sport clubs
Authors: Adriaens Karolien , Verhelle Helena , Peters Gjalt-Jorn Ygram , Haerens Leen , Vertommen Tine
Published: June 2024

Harassment and abuse represent a pervasive and critical problem in sport with far-reaching consequences. Survivors’ testimonials underscore the profound and enduring impact of these experiences at individual, interpersonal, organizational and community level. Many of their stories reveal painful inaction from responsible adults in the sport organization, aggravating the harm. Other contributing factors to the harm inflicted include a culture of silence, lack of knowledge and understanding of what constitutes abuse, unawareness of reporting and supporting mechanisms, and fear of potential consequences. While effective bystander interventions have been developed outside the sport context, particularly targeting students in higher education, such initiatives have yet to be extensively adapted and assessed within the sport context. To address this gap, the Safe Sport Allies Erasmus+ collaborative partnership relied on the intervention mapping approach as a guiding framework to systematically develop a bystander training program (i.e., Safe Sport Allies) to train youth sport participants and youth sport coaches to act as effective bystanders. The current paper describes the comprehensive development process and provides an overview of implementation and evaluation possibilities. Throughout the paper, it is explained how each step of the Intervention Mapping approach shaped the Safe Sport Allies bystander training program. The program development, and the developed plans for implementation and evaluation are presented, shedding light on challenges encountered. The bystander training program developed in this paper and the implementation and evaluation plans can serve as an outline to build future interventions within this critical domain of safeguarding in sport.
The darkness of reacculturation: examining factors influencing depression among Chinese international student returnees in the post-COVID-19 era
Authors: Jin Ruining , Wei Jie , Wang Xuanyi , Le Tam-Tri
Published: June 2024

Introduction

In the aftermath of the COVID-19 pandemic, the reintegration of Chinese international student returnees intersects with China’s critical effort to combat a significant brain drain of highly skilled talents, highlighting an unprecedented psychological battleground. This convergence underscores the urgent need for nuanced research to navigate the uncharted territory of their mental health.

Methods

Employing Bayesian analysis supported by Markov Chain Monte Carlo (MCMC) algorithms, this study examined depression prevalence and associated factors among 1,014 Chinese returnees. The sample comprised 44.87% male participants (455), 51.58% female participants (523), and 3.55% identifying as “Others” (36), with an age distribution of 61.74% aged 18-30 (626), 28.80% aged 31-40 (292), and 9.47% aged 41-50 (96). The mean age of participants was 29.6 years, ranging from 18 to 50 years. PHQ-9 diagnoses revealed alarming levels of depression, with 47.9% exhibiting a moderately severe degree of depressive disorder.

Results

Our findings highlight the intricate interplay between identity clusters— “homestayers” (those leaning towards a Chinese cultural identity), “navigators” (those with a bicultural identity), and “wayfarers” (those leaning towards a foreign cultural identity)—and the likelihood of depression. Specifically, homestayers showed a clear and strong negative association, navigators demonstrated a positive association, and wayfarers had a positive yet unclear correlation with depression levels. Furthermore, acculturation, age, and gender showed no significant effects, whereas education mildly mitigated depression.

Discussion

Based on these findings, we suggest the implementation of better-tailored mental health support and policies to facilitate smoother reintegration.
The inductive effect of musical mode types on emotions and physiological responses: Chinese pentatonic scales versus Western major/minor modes
Authors: Jiang Yihe , Zheng Maoping
Published: June 2024

Background

The value of music lies in its ability to evoke emotions. People can gain emotional experiences in music and can also regulate their own emotions through music. Music has its own structural rules, and exploring the relationship between musical structure and emotions is an important approach to understanding the mechanism of music-induced emotions. Musical mode refers to the arrangement of intervals around the tonic, presenting different musical modes based on the central tone and the arrangement of intervals, including Chinese pentatonic modes and Western major and minor modes. Musical morphology indicates significant differences in the construction intensity of traditional Chinese pentatonic modes and major and minor modes, affecting their mode forms and thus determining their adaptability to external influences.

Aims

Exploring the modalities of music and the effects of individual music training experiences on emotion induction; validating whether musical modes exhibit cross-cultural universality in the process of emotion induction.

Method

This study recruited 65 university students as participants (34 with music training experience, 31 without music training experience). Through a passive listening paradigm using the GEMS and combined with a biofeedback equipment, it explored the differences in behavioral and physiological indicators (skin conductance, temperature, heart rate) of emotional experiences (basic and aesthetic emotions) influenced by the modal forms of Chinese traditional pentatonic modes and Western major and minor modes.

Results

Firstly, the arousal level of music emotion is a primary factor influencing individuals’ aesthetic emotional experiences in music, which is related to the intensity of modal construction in music; Secondly, the emotional pleasure and skin temperature change induced by pentatonic music are greater than those induced by major and minor modes; Thirdly, the arousal level, electrodermal change, and heart rate variability of major and minor modes are greater than those of pentatonic music; Finally, music training experience enhances college students’ familiarity and preference for pentatonic music, thereby strengthening the electrodermal physiological indicators of emotional experiences.

Conclusion

The different modal forms of music express different levels of emotional arousal, leading to differences in individuals’ emotional dimensions and physiological indicators in music. Additionally, individuals’ music training experiences and cultural backgrounds also influence their experience of music emotions.
Experience of CBT in adults with ADHD: a mixed methods study
Authors: William Sandy , Horrocks Matthew , Richmond Jemma , Hall Charlotte L. , French Blandine
Published: June 2024

Introduction

The National Institute for Health and Care Excellence (NICE) recommends Cognitive-Behavioural therapy (CBT) as the psychotherapeutic treatment of choice for adults with Attention Deficit Hyperactivity Disorder (ADHD) in the UK. However, the literature often refers to adapted CBT programs tailored for ADHD and provides limited insight into how adults with ADHD experience and perceive this form of treatment in routine clinical practice.

Methods

This mixed-methods study aims to explore ADHD individuals’ experience and perception of CBT delivered in routine clinical practice, to gain a better understanding of this treatment’s helpfulness and perceived effectiveness.

Results

A survey (n=46) and semi-structured in-depth interviews (n=10) were conducted to explore the experience of CBT and its perceived effectiveness in managing ADHD. The interviews were analysed using thematic analysis and the survey was synthesised using descriptive narratives. The thematic analysis highlighted three key themes: difficulties with the CBT framework, difficulties with CBT therapists, and consequences of CBT. The survey highlighted similar findings. Participants described the CBT framework as, generic, rigid, and too short, and described the CBT therapist as unspecialised, unempathetic, and not sufficiently adapting CBT to ADHD-related difficulties.

Discussions

Overall, participants found non-adapted, generic CBT in the UK to be unhelpful, overwhelming, and at times harmful to their mental well-being. Therefore, it is necessary for clinical bodies in the UK, while following the indicated NICE guidelines, to be mindful of adapting CBT delivery of CBT, to be most effective for people with ADHD and to mitigate potential harm.
Anxiety among children a year after the onset of the COVID-19 pandemic: a Brazilian cross-sectional online survey
Authors: Garcia de Avila Marla Andréia , de Jesus Amorin Tainara , Hamamoto Filho Pedro Tadao , de Almeida Graziela Maria Ferraz , Olaya-Contreras Patricia , Berghammer Malin , Jenholt Nolbris Margaretha , Nilsson Stefan
Published: June 2024

Aim

This study seeks to build upon a prior investigation into the impact of the COVID-19 pandemic and to evaluate the prevalence of anxiety among Brazilian children, along with its associated factors, one year after the commencement of the pandemic.

Design

A cross-sectional study.

Methods

A survey was conducted from April–May 2021 in Brazil. Children aged 6–12 and their guardians from five Brazilian regions were included. The Children’s Anxiety Questionnaire (CAQ; scores 4–12) and Numerical Rating Scale (NRS; scores 0–10) were used to measure anxiety.

Results

Of the 906 children, 53.3% were girls (average age = 8.79 ± 2.05 years). Mothers responded for 87.1% of the children, and 70.9% were from the Southeast region. Based on a CAQ score of ≥9 and an NRS score of ≥8, the anxiety prevalence was 24.9 and 34.9%, respectively. Using logistic regression, a CAQ ≥9 score was associated with older children and children with chronic disease or disability. An NRS score of ≥8 was associated with reduced family income during the pandemic, the person caring for the children, and with children with chronic disease or disability.

Conclusion

These findings suggest the need to implement public health actions aimed at children with chronic diseases and disabilities and their parents to guide them regarding the warning signs and negative emotions. This study contributes to characterizing the evolution of the pandemic in Brazil and provides a basis for comparison with the literature from other countries.
Health beliefs of unmarried adult Saudi individuals toward safe marriage and the role of premarital screening in avoiding consanguinity: a nationwide cross-sectional study
Authors: Alwhaibi Reem M. , Almuwais Afrah K. , Alotaibi Madawi , AlTaleb Hanan M. , Alsamiri Shatha M. , Khan Ruqaiyah
Published: June 2024

Introduction

Premarital screening (PMS) is an essential global measure that seeks to reduce the occurrence of specific genetic disorders and sexually transmitted diseases common in consanguineous marriages. Due to the lack of a nationwide study, this research was designed to comprehend how unmarried individuals perceive the risks and benefits of PMS.

Method

A cross-sectional study was conducted using an online questionnaire distributed through different social media platforms, responses from the native adult population (18–49 years) Saudi Arabia was only included in the study. The questionnaire was based on the Health Belief Model (HBM) to assessing seven different constructs including susceptibility, seriousness, benefits-, barriers-, & cues- to action, self-efficacy, and social acceptance. Data frequency was represented by mean and standard deviation; chi-square and t-tests were conducted for the comparison of independent and dependent variables. A multinomial logistic regression was used to predict factors influencing decisions related to PMS.

Results

1,522 participants completed the survey, mostly 18–25 years old and most of them were women. The majority were single with 85 men and 1,370 women. Most participants (59.6%) believed their parents were related, while 40.5% did not. 122 respondents reported they had to marry within their tribe. Findings revealed significant correlations among all HBM themes, with varying strengths. Notably, a moderate positive relationship was found between the perception of benefits and cues to action, suggesting that enhancing the perceived benefits of PMS could facilitate safe marriage practices. Multinomial regression analysis revealed that demographic factors and health beliefs significantly influence individuals’ intentions and behaviors toward PMS and safe marriage.

Conclusion

The study concludes that by identifying and addressing barriers, and promoting positive social acceptance, PMS can significantly contribute to preventing genetic diseases and promoting safe marriage practices, although the cross-sectional design limits the establishment of causal relationships and further research is needed.
Perspectives of people with spinal cord injury on a pain education resource
Authors: Fernandez Gabriel E. , Anderson Kim D. , Vastano Roberta , Frank Scott I. , Robayo Linda E. , Cherup Nicholas P. , Kochen William , Widerström-Noga Eva
Published: June 2024

Introduction

Spinal cord injury (SCI) often leads to neuropathic pain that negatively affects quality of life. Several qualitative research studies in individuals with SCI who experience neuropathic pain indicate the lack of adequate information about pain. We previously developed an educational resource, the SeePain, based on scientific literature and a series of qualitative interviews of people with SCI, their significant others/family members, and SCI healthcare providers.

Methods

However, to quantitatively evaluate the utility of this educational resource in a larger sample, we examined the agreement and usefulness ratings of statements regarding clarity/comprehensibility, content, and format of the SeePain, derived from the thematic analysis of our previous qualitative interviews. Participants completed a survey that provided a digital version of the SeePain and then rated their agreement/usefulness with the statements using numerical rating scales.

Results

There were overall high perceived agreement and usefulness ratings regarding the SeePain’s clarity, content, and format. A factor analysis reduced the agreement and usefulness ratings into 4 components (content, clarity, format, and delivery medium). Group comparisons showed that individuals with higher education were more likely to endorse electronic and website formats, and the usefulness of a shorter version of the SeePain; females and younger individuals showed greater endorsement for clarity. Finally, higher pain intensity ratings were associated with greater agreement and usefulness of the content of the SeePain.

Discussion

Overall, these results support the utility of the SeePain as a source of information regarding pain that may facilitate communication about pain and its management following SCI.
Dairy factory milk product processing and sustainable of the shelf-life extension with artificial intelligence: a model study
Authors: Oztuna Taner Oznur , Çolak Andaç Batur
Published: June 2024

This study models milk product processing and sustainable of the shelf-life extension in a dairy factory using artificial intelligence. The Cappadocia dairy factory was used to study chemical processes and computational system modeling and simulation. Levenberg–Marquardt algorithm was used to create an artificial neural network model from real-time data. An AI-based method utilizing a Multilayer Perceptron (MLP) Artificial Neural Network (ANN) model was employed to precisely analyze productivity data in dairy factories. There are 9 product types and production quantities used as input parameters, and 90 datasets of actual dairy products used as output values. The model was trained using the Levenberg–Marquardt algorithm on 62 datasets for training, 14 for validation, and 14 for testing. The accuracy of the model is affected by the optimal data segmentation. The model showed how AI algorithms can improve processes and industrial production by increasing dairy production efficiency from 20 to 40%. Model efficiency values were compared to observed values to determine prediction accuracy. Model mean squared error was 4.02E-06, and coefficient of determination was 0.99984. Model efficiency predictions and observed values differed by −0.04% on average. This study investigated using artificial intelligence to optimize salvage processes and systems to increase energy efficiency and reduce environmental impact. The results show that a neural network model trained with real data can predict dairy plant productivity.
Experimental description of heat transfer processes at two-phase flow in microchannels towards the development of a heat sink for PV panels
Authors: Pontes Pedro , Marseglia Guido , Perez Mariana , de Giorgi M. G. , Moreira A. L. N. , Moita Ana S.
Published: June 2024

The development of new and more effective cooling technologies is required for several high thermal power dissipation applications such as in electronics cooling or high concentrated photovoltaic panels. The present paper addresses an experimental study on the development of a microchannel based heat sink to cool photovoltaic panels. Experiments focus on the test of a microchannel, with geometry and dimensions optimized from previous work. The analysis performed here emphasizes the experimental characterization of flow boiling in the microchannel under different working conditions. The results include pressure drop and heat flux maps, obtained combining pressure sensors with high-speed imaging and time resolved thermography. The analysis performed was able to identify where nucleation sites were formed. Slug flow interfacial heat transfer could be observed and accurately described in the heat flux maps. Overall, results show the high potential of combining high-speed imaging with time resolved infrared thermography to characterize complex flows. These results also show that there is a good potential for this microchannel based flow cooling in removing the required heat fluxes for the application considered here, when compared to other liquid and air-cooling technologies.
Association of results of the glutaraldehyde coagulation test with plasma acute phase protein concentrations and hematologic findings in hospitalized cows
Authors: Trefz Florian M. , Balmer Martina , Peters Laureen M. , Bruckmaier Rupert M. , Meylan Mireille
Published: June 2024

Introduction

The glutaraldehyde test (GAT) allows for animal-side semi-quantitative estimation of fibrinogen and gamma-globulin concentrations in blood samples of adult cattle and therefore detection of inflammatory disease conditions. However, the test has potential limitations, especially due to the latency period until sufficiently high fibrinogen and/or gamma-globulin concentrations are reached. The aim of the present study was therefore to assess the association between results of GAT with other inflammatory markers including hematologic variables, fibrinogen, plasma haptoglobin and serum amyloid A (SAA) concentrations.

Methods

For the purpose of this prospective observational study, a convenience sample of 202 cows with a broad range of inflammatory and non-inflammatory clinical conditions was included. The GAT was run on EDTA blood, fibrinogen was measured using the Clauss and the heat precipitation method, and commercially available ELISA tests were used for determination of plasma haptoglobin and SAA concentrations.

Results

Shortened GAT coagulation times were more closely correlated to serum globulin (rs = −0.72) than to plasma fibrinogen concentrations measured with the heat precipitation (rs = −0.64) and the Clauss method (rs = −0.70). Cows with a markedly (≤3 min) or moderately (4–6 min) shortened coagulation time had higher (p < 0.001) plasma haptoglobin and SAA concentrations than cows with a negative test result. Total leukocyte, monocyte and neutrophil concentrations did not differ significantly between groups. An identified cut-off for the GAT coagulation time of ≤14 min had a sensitivity and specificity of 54.4 and 100%, respectively, for the prediction of an inflammatory state based on clinical findings and/or increased plasma haptoglobin or SAA concentrations.

Discussion

In conclusion, this study demonstrates considerable diagnostic agreement between positive GAT results and increased plasma concentrations of haptoglobin and SAA. Despite high specificity, the test lacks sensitivity in case of acute inflammatory conditions indicating that plasma acute phase protein concentrations and hematologic findings can provide additional diagnostic information if the GAT is negative.
Sunflower Origin Identification Based on Multi-Source Information Fusion Technique of Kernel Extreme Learning Machine
Authors: Suo Limin , Liu Hailong , Ni Jin , Wang Zhaowei , Zhao Rui
Published: June 2024

This study constructs a model for the rapid identification of the origins of edible sunflower (Helianthus) using Kernel Extreme Learning Machine (KELM) with multi-source information fusion technology. Near-infrared spectroscopy (NIRS) and nuclear magnetic resonance spectroscopy (NMRS) were utilized to analyze 180 sunflower samples from the Xinjiang, Heilongjiang, and Inner Mongolia regions. Initially, the identification models for the origin of sunflowers using NIR and NMR data were compared between two algorithms: the Extreme Learning Machine (ELM) and KELM, combined with various spectral preprocessing methods. The experiment found that the NIR spectral model preprocessed with standard normal variate (SNV) using the KELM algorithm was the most accurate, achieving accuracies of 98.7% in the training set and 97.2% in the test set. The spin-echo NMR spectral model preprocessed with non-local means (NLMs) using the KELM algorithm was the second best, with accuracies of 98.4% in the training set and 96.4% in the test set. To further improve the accuracy of the identification models, innovative sunflower origin identification models were developed based on data layer fusion and feature layer fusion using NIRS and NMRS. In the data layer fusion model, the KELM algorithm model was optimal, achieving a test set accuracy and F1 score of 98.2% and 98.18%, respectively, an improvement of 1.0% over the best single data source model. In the feature layer fusion model, four types of feature-layer information-fusion identification models were established using two feature extraction algorithms, Competitive Adaptive Reweighted Sampling (CARS) and Variable Importance Projection (VIP), combined with joint feature and simple merging feature strategies. The CARS-KELM algorithm combined with the joint feature method was found to be the best, achieving 100% accuracy in both the training and test sets, an improvement of 2.8% over the best single data source model. Identifying the origin of edible sunflower using NIRS and NMRS is demonstrated as feasible by the results. The best single-spectrum sunflower origin identification model was achieved using the KELM algorithm with SNV preprocessing. The feature layer fusion method combining NIRS and NMRS data is suitable for handling the task of sunflower origin identification. This method significantly improves the recognition accuracy of the model compared to a single model, achieving fast and accurate origin identification of edible sunflowers. The research results provide a new method for rapid identification of sunflower origin.
An Improved YOLOv8 Model for Lotus Seedpod Instance Segmentation in the Lotus Pond Environment
Authors: Ma Jie , Zhao Yanke , Fan Wanpeng , Liu Jizhan
Published: June 2024

Lotus seedpod maturity detection and segmentation in pond environments play a significant role in yield prediction and picking pose estimation for lotus seedpods. However, it is a great challenge to accurately detect and segment lotus seedpods due to insignificant phenotypic differences between the adjacent maturity, changing illumination, overlap, and occlusion of lotus seedpods. The existing research pays attention to lotus seedpod detection while ignoring maturity detection and segmentation problems. Therefore, a semantic segmentation dataset of lotus seedpods was created, where a copy-and-paste data augmentation tool was employed to eliminate the class-imbalanced problem and improve model generalization ability. Afterwards, an improved YOLOv8-seg model was proposed to detect and segment the maturity of lotus seedpods. In the model, the convolutional block attention module (CBAM) was embedded in the neck network to extract distinguished features of different maturity stages with negligible computation cost. Wise-Intersection over Union (WIoU) regression loss function was adopted to refine the regression inference bias and improve the bounding box prediction accuracy. The experimental results showed that the proposed YOLOv8-seg model provides an effective method for “ripe” and “overripe” lotus seedpod detection and instance segmentation, where the mean average precision of segmentation mask (mAPmask) reaches 97.4% and 98.6%, respectively. In addition, the improved YOLOv8-seg exhibits high robustness and adaptability to complex illumination in a challenging environment. Comparative experiments were conducted using the proposed YOLOv8-seg and other state-of-the-art instance segmentation methods. The results showed that the improved model is superior to the Mask R-CNN and YOLACT models, with recall, precision, mAPbox and mAPmask being 96.5%, 94.3%, 97.8%, and 98%, respectively. The average running time and weight size of the proposed model are 25.9 ms and 7.4 M, respectively. The proposed model obtained the highest mAP for lotus seedpod maturity detection and segmentation while maintaining an appropriate model size and speed. Furthermore, based on the obtained segmentation model, 3D visualization of the lotus pond scene is performed, and cloud point of lotus seedpods is generated, which provides a theoretical foundation for robot harvesting in the lotus pond.