bluuebunny/crossref_metadata_2025 huggingface dataset:
Acuity-Based Allocation of ICU-Downstream Beds with Flexible Staffing
Authors: Valeva Silviya , Pang Guodong , Schaefer Andrew J. , Clermont Gilles
Published: January 2023

Intensive care units (ICUs) are crucial resources within hospitals, caring for the most critically ill patients. We propose a novel modeling framework that improves the outflow of ICU patients by anticipating unit interactions and resource sharing within the system. Across an arbitrary bipartite network of units, we consider two types of downstream staffing (baseline and flexible) and a two-stage decision process. In the first stage, we determine the level of flexible bed staffing using existing physical beds at downstream units in anticipation of incoming transfers from the ICUs. In the second stage, we determine the allocation of ICU patients to downstream beds. The goal of the model is to reduce inefficiencies and transfer delays causing ICU bed block due to lack of space in downstream units. We formulate a dynamic multiperiod model and analyze the dual of its (relaxed) stationary counterpart. Decomposing the relaxed stationary model into an ICU and downstream subproblems, we calculate the relative values of downstream beds and derive a practical acuity-based policy for the daily operational decisions. Using a large-scale simulation calibrated with historic hospital data, we demonstrate that our acuity-based policy reduces the number of long-run diverted ICU arrivals, particularly in high-demand scenarios, thus improving ICU throughput, when compared with a deterministic, a generalized randomized-most-idle, and static policies.

History: Accepted by J. Paul Brooks, Area Editor for Applications in Biology, Medicine, & Healthcare.

Funding: This work was partially supported by National Science Foundation [Grants CMMI-1635301/1635410/1635642].

Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1267 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0133 ) at ( http://dx.doi.org/10.5281/zenodo.7194693 ).
Travel Murah Jogja’s Instagram Content Management at post Covid-19 Pandemic
Authors: Hafifah Nabila , Sudiwijaya Erwan , Aulia Aly
Published: January 2023

Purpose. The Covid-19 task force issued Letter Number 18 of 2022 regarding the rule for domestic travel during the Covid-19 pandemic. This led to an increase in the number of tourists coming to Yogyakarta. Tourist interest in visiting Yogyakarta can be seen from the increase in followers from tourist information provider accounts, one of which is @travelmurahjogja which has increasing numbers of followers despite the productivity of content creation has decreased from 2019 – 2021. This research aims to understand the content management of Travel Murah Jogja through Instagram @travelmurahjogja in response to the increasing tourist interest.Design/Methodology/Approach. The methodology in this research is descriptive qualitative. The data was obtained from interviews with the owner and admin of social media @travelmurahjogja, observations on the official Instagram @travelmurahjogja, and documentation of reports in online media.Finding. @travelmurahjogja manages the content on its Instagram to target the middle to lower market share. The idea and planning of content that is neatly arranged and uses bright color tones.Suggestion. It is recommended that Travel Murah Jogja further deepen the evaluation by utilizing the insight feature to maximize the performance of post-distribution content.
Jiwa Jawi Content Management on Instagram @jiwajawijogja 2021
Authors: Fidela Almira Rahma , Sudiwijaya Erwan , Aulia Aly
Published: January 2023

Purpose. The food (culinary) industry is currently one of the fatest- growing businesses. The Indonesian culinary tourism is not only in terms of the menu but also the art, culture, and philosophical values that make up the dish. The culinary business's development is increasing daily in Yogyakarta, and culinary tourism continues to grow every year. Culinary promotion patterns have also penetrated social media, one of which is @jiwajawijogja, which opened a new branch in Pogung  with the name Jiwa Jawi Jogja.The methodology in this research is descriptive qualitative with data obtained from interviews with owner and content designer from @jiwajawijogja, observations on the official Instagram @jiwajawijogja, and documentation from news in online media.A finding of this study is the process of creating content at @jiwajawijogja has received a positive response through events that aim to bring the brand closer to its followers.Suggestion from this research to ensure the message is conveyed properly, we suggest that @jiwajawijogja focus on its targets audience and create hashtags according to the target audience.
Against Campus Sexual Predators in "Mata Najwa" Television Programme
Authors: Tirahmawan Jaza , Junaedi Fajar
Published: January 2023

In this study, researchers took the television program Mata Najwa on Trans 7 edition of "Ringkus Predator Seksual Kampus" (in English : Arrest Sexual Predator in Campus) as the research object to be analyzed as a narrative text in a talk show. This study aims to find out how the narrative of sexual violence is presented in the Mata Najwa programme. In this study, the researcher used descriptive qualitative research, and the researcher used data collection techniques such as literature study and documentation in collecting data by looking at the documentation on the Mata Najwa show "Ringkus Predator Seksual Kampus" edition. By using the narrative analysis method, Algirdas Greimas' actantial model determines six characters in a narrative. The analysis will help explain the narrative system and interpret the underlying narrative. The results of this study indicate that Mata Najwa seeks to uncover cases of sexual violence on campuses in Indonesia. The Mata Najwa program can convince the public that the event cares about the problems that plague students who are victims of sexual violence that are often ignored by the campus. Thus, people do not judge the event as an event that only pursues ratings. If conclusions are drawn in his presentation, Najwa Shihab always leads to an open answer so that people can assess sexual violence and policies, in this case, the Minister of Education and Culture, from various perspectives.
Sexual Violence in Online Media Framing, How Detik and Tribunnews Make Their Different Perspective
Authors: Haroom Muhammad Masyaril
Published: January 2023

The media plays an essential role in shaping public opinion. What the media shows automatically constructs people's mindsets. Different ideologies result in each the media views events from another point of view. Sexual assault cases on students conducted by Herry Wirawan in Bandung became the attention of various media online in Indonesia, especially Detik and Tribunnews. The purpose of this research is to find out the analysis of framing in the media of Detik and Tribunnews regarding cases of news about student rape. This study uses qualitative research methods with a framing analysis method and constructivism paradigm. Collection technique data is carried out by collecting documents regarding cases rape of students in Bandung. The data analysis technique used is the framing analysis model by Robert N. Entman. The research shows that Detik and Tribunnews frame the news from different perspectives. the news published by Detik emphasises the facts of the trial and legal questions that will trap the perpetrators accordingly to applicable law. Meanwhile, Tribunnews framed this case as related to Apart from that, Herry Wirawan's personal life has tarnished the teacher's image in the Eyes community. Tribunnews also framed the news that the victim needed to get protection. On the other hand, Detik News puts forward the frame that the perpetrator should receive castration or life imprisonment.
SEX EDUCATION IN DUA GARIS BIRU
Authors: Sabri Sabri Sabri
Published: January 2023

Dua Garis Biru is a movie produced in 2019 and directed by Gina S Noer. At the beginning of its screening, the movie received many pros and cons for fear of having negative effects on its audience. Dua Garis Biru takes on the theme of sex education. Sex education is a taboo subject rarely discussed by the general public. Through Dua Garis Biru, Gina S Noer tells the life of two teenagers who had sexual intercourse outside marriage, resulting in pregnancy outside marriage. Through cinematographic elements in this film, it illustrates the lack of early sexual education from parents and the school environment. This movie depicts the importance of sex education in preventing unwanted circumstances. The research method used by the author was the descriptive analysis with a reception analysis approach. Stuart Hall’s reception analysis used in the present study was through the audience’s point of view. This movie also illustrates how parents generally deal with serious problems that can threaten their children’s futures. Parents are sensitive when it comes to the future of their children.
The ‘Shift Left’ Principle
Authors: Pitchford Mark
Published: January 2023

Why it’s so important to design and test for security early and continuously when it comes to embedded systems.
New Snapdragon Mobile Platforms
Authors: Hathway Charlotte
Published: January 2023

Qualcomm launches three new Snapdragon mobile platforms.
A Demanding Challenge
Authors: Patyuchenko Anton
Published: January 2023

Modern Medical Imaging Systems Depend on the Performance of Data Converters
Time to Modernise
Authors: Howard Steve
Published: January 2023

Steve Howard of RogueWave Software talks to New Electronics about why it's time to modernise software development in aviation
EuMW Highlights New Frontiers for 5G
Authors: Duncan Helen
Published: January 2023

With the roll-out of 5G a reality, this year's Microwave Week focused on technologies suitable for large-scale production. By Helen Duncan
Better Starts here
Authors: Austin-Morgan Tom
Published: January 2023

At Autodesk University in November, CEO Andrew Anagnost described how technology must be used more efficiently, to design products that benefit society, and to create better jobs.
The Missing Link
Authors: Veisz Dave
Published: January 2023

COVID-19 has dramatically exposed the fragility of today’s ‘just-in-time’ global supply chains. MakerBot’s VP Engineering, Dave Veisz, looks at the lessons learnt.
Policy for First Nations Self-Determination in Health: An Analysis of Problems, Politics, and Policy Related to Medical Travel in Northwest Territories
Authors: Milligan Crystal , Irlbacher-Fox Stephanie , Dobrow Mark J.
Published: January 2023

Medical travel, where a patient travels to a larger centre for services not available in their home community, is a critical element of the Northwest Territories (NT) health care system. For residents with a valid NT health care card who do not have other coverage for medical travel, the territorial government administers some travel benefits through the NT Medical Travel Program as well as the federally funded non-insured health benefits program. The Gwich'in Tribal Council (GTC) recognizes that medical travel constitutes a major burden and presents extraordinary challenges for Gwich'in living in small remote communities in NT. In 2020, the GTC conducted research that suggests current policy and programs provide only partial access to care. Informed by Gwich'in medical travel stories and drawing from literature on the concepts of health care access, knowledge, power, and Indigenous rights, this article reframes prevailing understandings of the problems, politics, and policy associated with medical travel in NT. The authors contend that relevant and equitable medical travel in NT depends on policy-making that engages First Nations as equal partners with different levels of government and describe key considerations relevant to policymakers in NT and throughout Canada.
Educación Superior y tutoría: uso del aula virtual en contabilidad
Authors: Ortiz Martínez Esther , Santos Jaén Jose Manuel , Gras Gil Ester
Published: January 2023

La tutoría es una herramienta clave en la enseñanza universitaria que ha evolucionado hacia tutoría virtual. El objetivo del presente trabajo es realizar una clasificación de las tutorías virtuales, para posteriormente analizar si vienen determinadas por el sexo de los estudiantes, el hecho de que se trate de un trabajo fin de grado o máster, o el medio concreto a través del que se realizan. Para ello se ha confeccionado un base de datos con 807 tutorías virtuales en asignaturas de contabilidad, a partir de la que se ha realizado una clasificación de las mismas y un análisis explicativo con un modelo de regresión categórica con escalamiento óptimo. Las principales conclusiones obtenidas subrayan que la tutoría virtual se sigue utilizando con fines académicos y sobre todo la importancia que cobra este tipo de tutoría en la asignatura de trabajos finales.
From Bourbon Reform to Open Markets in California, 1801-1821
Authors: Duggan Marie Christine
Published: January 2023

The Consulado de México was the mercantile guild that acted as commercial nerve-center of Spain’s empire in the Americas. From 1801 to 1821, one of its members, Pedro González de Noriega, influenced California’s economic growth by putting his nephew, José de la Guerra y Noriega, into the colony’s military supply line. In 1801, for what purpose did De la Guerra y Noriega come to California? Whatever his intention, his life-plan changed in 1810, when insurgency broke out in New Spain, and military payroll ceased to arrive in California. Between 1811 and 1821, how did De la Guerra y Noriega adapt to this structural change by negotiating with international merchants from Manila to San Blas and Lima to supply California? As Spain’s empire unraveled, we follow the microhistory of the Noriega mercantile network, as it reconfigured to the macroeconomic context of political transformation of the Pacific Rim in the context of Mexican independence from Spain. The De la Guerra Collection at the Santa Bárbara Mission Archive-Library reveals that Guadalajara was Mexico’s emerging center for Pacific commerce, with San Blas as Guadalajara’s principal port. By Mexican independence in 1821, De la Guerra had established Santa Bárbara, California as the center of his family’s business, rather than Mexico City. Even as Manila merchants relocated to Tepic, he maintained ties with them.  He also traded with the British in Callao, Peru, which is how he came to send his son to be educated in Liverpool with the Brotherston family.
Tácticas políticas y actividades de imagen en el discurso normalista estudiantil
Authors: Aguilera Ramírez Lariza Elvira
Published: January 2023

En el presente artículo planteamos resolver cuestiones referentes a las actividades vinculadas con la construcción de la imagen que en el intercambio comunicativo elaboran estudiantes normalistas; el tipo de estrategias discursivas que adoptan, ya sea cortesía, descortesía y/o autoimagen, así como la forma de la imagen: reparación, protección o realce. Articulamos con lo anterior las tácticas políticas que se configuran en el discurso normalista y su funcionamiento. Con base en la teoría y en el conocimiento del corpus, partimos del siguiente supuesto: El cuidado de la imagen propia por parte de los normalistas se realiza mediante actividades de autoimagen, en particular en la forma de realce, acuden a las tácticas de legitimación y resistencia para fortalecer la imagen de sí mismos como docentes y a la deslegitimación de los profesores de origen universitario para distanciarse de ellos. En este estudio se acude la teoría de la imagen social de Goffman (1967, 1970, 1983, 2006, 2009) y la sociopragmática cultural con las contribuciones de Bravo (1999, 2003, 2004, 2012, 2015, 2017) y Hernández (2013); para el estudio de las tácticas políticas a las propuestas de Chilton y Schäffner (2000) y Chilton (2004).
Didáctica de Filosofía para Niñas y Niños
Authors: Cárdenas Benítez Wilmer Javier , Mendoza Sánchez Mario Andrés
Published: January 2023

La Filosofía para Niñas y Niños -FpNN- en la escuela pública, atraviesa el reto de pensar las posibilidades de acción pedagógica que tensione los saberes y prácticas de la enseñanza en el campo de la filosofía en medio de la crisis civilizatoria y post pandémica. Esta propuesta responde a este reto que consiste en un andamiaje didáctico, síntesis de un programa y una metodología de enseñanza denominada Unidad de Acción Didáctica de FpNN, implementada en el Colegio Antonio Baraya de Bogotá desde el año 2015, con el fin de vincular la praxis de la investigación y la reflexión teórica de una filosofía crítica latinoamericana bajo el horizonte disciplinar de la ética, la estética y la política, que ofrezca estrategias y herramientas de acción didácticas para la formación humana de ciudadanías participativas en la infancia y su rol como sujetos con las capacidades humanas necesarias para incidir en la organización de sus comunidades desde la indagación, el diálogo, la disertación y la creación de su ser-estando como alternativa para mundos posibles.
NOVELLA ITALIANA BAJO SOSPECHA: EL "PECORONE" DE GIOVANNI FIORENTINO Y LA CENSURA LITERARIA EN LA ESPAÑA RENACENTISTA Y BARROCA
Authors: Núñez García Laureano
Published: January 2023

El Pecorone es una colección de cincuenta cuentos escritos a finales del siglo XIV por Giovanni Fiorentino. Sin embargo, la edición prínceps es posterior, de 1558. La Inquisición decretó rápidamente su prohibición, primero en Italia a partir de la década de los años setenta del siglo XVI y poco después en España. Este artículo se propone analizar los motivos por los que la obra fue censurada, que presumiblemente tuvieron que ver con el carácter inmoral que a juicio de los censores tenían algunos de sus cuentos y con la desconfianza que el género de las novelle suscitó en la Europa contrarreformista de la segunda mitad del siglo. Seguiremos así el rastro de las distintas prohibiciones en los índices de la Inquisición española, a partir del de Gaspar Quiroga de 1583, cotejándolos con otros índices europeos. También se estudia la traducción de Luis Gaitán de Vozmediano de uno de los cuentos en 1590. Esta traducción supone un ejemplo evidente de autocensura cuya finalidad debió ser, por un lado, evitar problemas con la Inquisición y, por otro, acercar el texto al ideario conservador e intransigente en materia de moralidad que se había impuesto a partir del Concilio de Trento.
LA FIGURA DE ORTENSIO LANDO EN LA ESPAÑA DE LOS SIGLOS XVI Y XVII: ENTRE RECEPCIÓN Y CENSURA
Authors: González de Sande Mercedes
Published: January 2023

Ortensio Lando fue un humanista de reconocido prestigio, no solo por la calidad de su vasta producción literaria, sino también por su conflictiva personalidad y las controversias que originaron algunos de sus escritos, considerados heréticos en muchos aspectos. Tal fue su fama y el interés que suscitaron sus escritos por toda Europa que muchas de sus obras fueron traducidas en diferentes idiomas al poco tiempo de ver la luz; de manera especial sus Paradossi, cioè sententie fuori del comun parere, publicados en 1543 y rápidamente ocultados y censurados, pero, a su vez, traducidos, reeditados, imitados y glosados por numerosos autores. Por lo que respecta a su recepción en España, cabe señalar que el autor tuvo una notable acogida, pero, al igual que en Italia y en otros países europeos, sus obras fueron inmediatamente censuradas, apareciendo su nombre en todos los Índices de libros prohibidos y, en especial, sus Paradossi, tanto en su versión italiana como española. Precisamente, de su recepción y de su censura en nuestro país pretendemos dar cuenta en este estudio, analizando cuáles pudieron ser los motivos que llevaron a prohibir la producción del humanista y qué aspectos de su figura y su obra despertaron mayor interés o rechazo.
DOMINGO VILLAR: TRADUCCIÓN E IMPACTO
Authors: Galanes Iolanda
Published: January 2023

En este artículo se analiza, desde los presupuestos de la Sociología de la literatura y de la traducción (Sapiro 2014), el impacto de la obra traducida de Domingo Villar en el sistema literario gallego. Se fija el corpus de traducciones de la obra de Villar, sus auto-traducciones y las de obra ajena, para determinar su relevancia en una cultura minorizada como la gallega. A partir del estudio de los datos de traducción, entrevistas y reseñas, se pondera el impacto de su traducción según los siguientes parámetros: texto fuente, número y espacios de las traducciones, formatos de edición, recepción y crítica de estas y, por último, los premios recibidos para determinar su relevancia en el espacio literario transnacional y en el sistema literario gallego.
Small-form-factor Gaussian-modulated coherent-state transmitter for CV-QKD using a gain-switched DFB laser
Authors: Aldama J. , Sarmiento S. , Etcheverry S. , Valivarthi R. , López Grande I. H. , Trigo Vidarte L. , Pruneri V.
Published: January 2023

We report a directly modulated distributed feedback laser operating in gain-switching mode for preparing the coherent states required for the Gaussian-modulated coherent-state (GMCS) continuous-variable quantum key distribution (CV-QKD) protocol. The proposed single-component quantum transmitter design eliminates the need for external modulators, decreasing the complexity of GMCS CV-QKD systems. The experimental results demonstrate a potential asymptotic secret key rate value of 2.63 Mbps over an 11-km fiber link, making the directly modulated GMCS transmitter particularly suitable for metropolitan optical networks where compactness, robustness, and low cost are key desirable features.
Crystal superlattices for versatile and sensitive quantum spectroscopy
Authors: Toa Zi S. D. , Chekhova Maria V. , Krivitsky Leonid A. , Paterova Anna V.
Published: January 2023

Nonlinear interferometers with quantum correlated photons have been demonstrated to improve optical characterization and metrology. These interferometers can be used in gas spectroscopy, which is of particular interest for monitoring greenhouse gas emissions, breath analysis and industrial applications. Here, we show that gas spectroscopy can be further enhanced via the deployment of crystal superlattices. This is a cascaded arrangement of nonlinear crystals forming interferometers, allowing the sensitivity to scale with the number of nonlinear elements. In particular, the enhanced sensitivity is observed via the maximum intensity of interference fringes that scales with low concentration of infrared absorbers, while for high concentration the sensitivity is better in interferometric visibility measurements. Thus, a superlattice acts as a versatile gas sensor since it can operate by measuring different observables, which are relevant to practical applications. We believe that our approach offers a compelling path towards further enhancements for quantum metrology and imaging using nonlinear interferometers with correlated photons.
Phase-modulated continuous-wave coherent ranging method for optical phased array lidar
Authors: Mingshi Zhang , Yubing Wang , Lanxuan Zhang , Qian Hu , Shuhua Zhao , Lei Liang , Yongyi Chen , Li Qin , Junfeng Song , Lijun Wang
Published: January 2023

Light detection and ranging (lidar) is widely accepted as an indispensable sensor for autonomous vehicles. There are two fundamental challenges in a lidar system: optical beam steering technique and ranging method. Optical phased array (OPA) is considered as one of the most promising beam steering schemes due to its solid state, compact size, and high reliability. As for ranging method, time-of-flight and frequency-modulate continuous-wave (FMCW) are commonly utilized in numerous research. However, they are impractical to commercial OPA lidar due to either requiring excessive optical power or the poor stability, high complexity, and high insertion loss of the FMCW source. As a result, the development of OPA lidars is significantly hindered by the lack of a feasible ranging method. In this paper, we present a phase-modulated continuous-wave (PhMCW) ranging method with excellent ranging accuracy and precision. Ranging error as low as 0.1 cm and precision on the order of 3.5 cm are achieved. In addition, theoretical and experimental study on simultaneous velocity measurement is carried out and velocity error as low as 0.15 cm/s is obtained. Finally, we develop a proof-of-concept OPA-PhMCW lidar and obtain a point cloud with excellent fidelity. Our work paves a novel approach to solid-state, cost-effective and high-performance OPA lidars.
Dual-channel-in-one temperature-compensated all-fiber-optic vector magnetic field sensor based on surface plasmon resonance
Authors: Hao Zijian , Pu Shengli , Lahoubi Mahieddine , Zhang Chencheng , Liu Weinan
Published: January 2023

All-fiber-optic magnetic field sensor integrated with magnetic fluid has been investigated for decades, accompanied by the commitment to vectorization, miniaturization, integration and solving the temperature cross-sensitivity caused by thermo-optic effect of magnetic fluid. A kind of dual-channel-in-one temperature-compensated all-fiber-optic vector magnetic field sensor was proposed and investigated theoretically in this work. Three optical surfaces, including two sensing surfaces (plated with gold film of 40 nm thickness and then coated with magnetic fluid and polydimethylsiloxane, respectively, referred as CH1 and CH2) and one reflective surface, were integrated on a single-mode fiber tip to facilitate the dual-channel-in-one design. The Kretschmann configurations were formed by the waveguide fiber, gold film and functional materials at the sensing surfaces (CH1 and CH2). Surface plasmon resonance was excited in different wavelength bands corresponding to CH1 and CH2. Attenuation wavelengths corresponding to CH1 and CH2 depend on the magneto-induced and temperature-induced refractive index change of functional materials, respectively, which makes the temperature-compensated magnetic field sensing possible. The non-centrosymmetric evanescent field generated by micro-fiber-tip-prism enables the vector magnetic field sensing. Especially, the length of the sensing area is only 115.5 µm, which achieves ultra-integration and miniaturization. The current work provides a novel scheme for designing all-fiber-optic vector magnetic field sensing based on magnetic fluid and demonstrates the realization of lab-on-a-fiber and then promotes the industrial application of all-fiber-optic vector magnetic field sensing devices.
SiN foundry platform for high performance visible light integrated photonics
Authors: Smith Jack A. , Francis Henry , Navickaite Gabriele , Strain Michael J.
Published: January 2023

We present a high performance silicon nitride photonic integrated circuit platform operating at visible wavelengths, accessible through the commercial foundry, LIGENTEC. Propagation losses were measured across the visible spectrum from 450 nm to 850 nm. For wavelengths above 630 nm, losses were <1 dB/cm in TE and <0.5 dB/cm in TM. Additionally, sets of single mode waveguide-coupled ring resonators across three separate chips were tested and analysed. A peak intrinsic Q factor of 3.69 × 106 was measured for a single resonance at ∼635.3 nm, with an average value of 2.28 × 106 recorded over 10 peaks in a 3 nm tuning range. Analyses of the loss and coupling, as functions of bus-ring coupling gap and waveguide width, are also presented. High confinement, low loss devices realised on the chip-scale in a wide-bandgap material like silicon nitride are increasingly important for the next generation of integrated optical devices operating at visible wavelengths.
‘Creativity Is Good for You’: Responding to the needs of our communities after COVID-19
Authors: Howard Jayne
Published: January 2023

This article explores how the pandemic has caused Arts Well, a small United Kingdom arts and health organization, to reflect on its future activities in order to be most useful in the space where arts and creativity meets health and well-being. It highlights the need for training, professional development and support for creative practitioners delivering participatory creative opportunities, recognizing the precarious work environment and emotionally demanding contexts in which they often work. Arts Well is also developing a campaign to raise awareness of the value of engaging in the arts and well-making to protect and improve health and well-being.
First meta-analysis study of cholinesterase inhibition in experimental animals by organophosphate or carbamate insecticides under the influence of diphenhydramine
Authors: Mohammad Fouad K. , Garmavy Hishyar M. S. , Mohammed Ammar A. , Rashid Hussein M.
Published: January 2023

Background and Aim: Diphenhydramine is an H1-antihistamine that counteracts the toxic effects of organophosphate and carbamate insecticides that inhibit cholinesterase (ChE) activity. This meta-analysis aimed to investigate the effects of diphenhydramine on ChE inhibition induced by these insecticides in the plasma, erythrocytes, or whole brain of experimental animals.

Materials and Methods: A data search was performed on erythrocyte, plasma, and brain ChE inhibition caused by organophosphate and carbamate insecticides in experimental animals (mice, rats, and chicks) treated with the antihistamine diphenhydramine in accordance with preferred reporting items for systematic reviews and meta-analysis, which was done by the two-group random-effects model meta-analysis. The meta-analysis included 18 records extracted from six studies that appeared from 1996 to 2022.

Results: Using the random-effects model, a two-group meta-analysis revealed that the combined effect size (ChE inhibition) was significantly more favorable in the control group than in the diphenhydramine intervention, as shown by a forest plot. The combined effect size (standardized mean difference) was 0.67, with a standard error of 0.3, a lower limit of 0.04, and an upper limit of 1.29 (p = 0.025). The heterogeneity was moderate, as I2 of the combined effect size was 74%, with a significant Cochrane Q-test result (Q = 65, p < 0.0001). Subgroup analysis indicated that, with brain ChE inhibition, the heterogeneity (I2) became 5%, which was lower than ChE inhibition in plasma (84%) and erythrocytes (78%). No publication bias was identified using the funnel plot and Egger's test.

Conclusion: This meta-analysis suggests that, in addition to its documented antidotal action against ChE-inhibiting insecticides, diphenhydramine can also reduce the extent of ChE inhibition, especially in the brain, which is the main site of toxicity of these insecticides. There is a need for additional studies to assess such enzyme inhibition in different parts of the brain.
An analysis of the injury severity of pedestrians in Brazil using random parameters logit models
Authors: Nogueira Silva Mateus , Craveiro Cunto Flávio José , Timbó Lima Gomes Marcos José , Ferreira Sara
Published: January 2023

In Brazil, pedestrians represent the third largest group of crash victims, after motorcyclists and car occupants. Implementing measures to ensure pedestrian safety and prioritization requires an understanding of the risk factors associated with crash injuries. In this study, a random-parameter logit model was estimated to investigate factors influencing the severity of crashes with pedestrians in urban roads in Fortaleza, Brazil. A sample of 2,660 observations of crashes with pedestrians in the city from 2017 to 2019 was used. The injury severity levels adopted by the Crash Information System (SIAT) were grouped into three categories: mild/moderate, severe and fatal. From the investigated factors, only the variable related to the pedestrian's age over 60 years old obtained a significant random parameter. In this case, the heterogeneity in the observations may be associated, among other factors, to the body’s physical fragility and the cognitive function that may differ among individuals in this group. The results showed that the driver’s gender and age, the crash site, the motorcycle use, and the presence of speed cameras did not have a significant impact on the severity of crashes with pedestrians. On the other hand, crashes occurring at night, with heavy vehicles, on weekends, and located on roads with higher traffic classification are associated with more severe injuries. The incorporation of unobserved heterogeneity in the estimation of the model's parameters stands out as one of the main contributions of this work.
Prevalence of hypoglycemic conditions in adolescents with type 1 diabetes mellitus in real clinical practice
Authors: Tsargasova I. M. , Bashnina E. B. , Vorokhobina N. V. , Dubinina T. A. , Dosovitskaya E. R. , Platonov V. V.
Published: January 2023

BACKGROUND. Hypoglycemia and fear of hypoglycemia remain critical problems in the treatment of adolescents with type 1 diabetes mellitus (DM1) and are factors limiting proper control of glycemia and preventing the achievement of metabolic compensation of the disease. The use of pump insulin therapy involves the prevention of hypoglycemic conditions.

AIM. To analyze the frequency and duration of hypoglycemia episodes, their effect on the metabolic compensation of the disease in adolescents with type 1 diabetes mellitus (DM1) in real clinical practice, depending on the mode/method of insulin administration.

MATERIALS AND METHODS. The study involved 117 adolescents with DM1 aged 12 to 19 years (average age 15.5 years). 37 adolescents received therapy by continuous subcutaneous insulin infusion (CSII); 80 adolescents received therapy by multiple insulin injections (MII). The level of glycated hemoglobin (HbA1c) was determined for all adolescents, and its main indicators were evaluated using a 6 days continuous glucose monitoring (CGM) by the «blind» method of a professional system with an iPro 2 sensor (Medtronic MiniMed, USA).

RESULTS. Episodes of a decrease in glucose levels <3,9 mmol/l were recorded in 87% of patients (n=102), 63% (n=74) showed a decrease in glucose levels <3,0 mmol/l. Episodes decrease in glucose levels <3,9 mmol/l at night were recorded in 68% of patients (n=80), and with glucose levels <3,9 mmol/l in 46% (n=54). The frequency of episodes of glucose lowering <3,9 mmol/l had no statistically significant differences depending on the methods of insulin administration (by continuous subcutaneous insulin infusion or multiple insulin injections), however, they are more common in adolescents with HbA1c <7,0% (p=0,03). The median time spent by patients in the range of <3,9 mmol/l was 5% per day, and a longer time in this range was observed in patients with HbA1c <7,0% (p=0,006). The median time in the range of <3,0 mmol/l was 1% per day and had no significant differences depending on the level of HbA1c (p=0,559). There were also no significant differences depending on the groups using CSII and MII (p=0,640 and p=0,250).

CONCLUSION. Episodes of glucose reduction in the range of <3,9 mmol/l according to CGM data are more common in adolescents with HbA1c target values, regardless of the method of insulin administration. Significantly more time in range of <3,9 mmol/l is spent by adolescents with target values of HbA1c i.е. <7,0% compared with HbA1c ≥7,0%, however, in both groups, a large number of patients had time in the range below the target level was higher than recommended values.
Características de los pacientes con acromegalia atendidos en el Hospital de Especialidades José Carrasco Arteaga. Cuenca, 2014 - 2019
Authors: Ordóñez Chacha Ana Karina , Sacoto Molina Adrián Marcelo , Cazorla Dután Marco Vinicio
Published: January 2023

BACKGROUND: Acromegaly is a rare, slow-onset and insidious disease characterized by growth hormone hypersecretion, generally associated with the presence of a pituitary adenoma. In Ecuador, the information about the epidemiological characterization of acromegaly is limited. The aim of this study was to determine the characteristics of the patients with acromegaly treated at Hospital de Especialidades José Carrasco Arteaga from January 1st, 2014 to December 31st, 2019. METHODS: This is an observational, descriptive, cross-sectional study. Data was collected from 88 electronic medical records of patients with a diagnosis of acromegaly treated during the aforementioned period. Statistical analysis was performed with PSPP 1.4.1 software. The results of qualitative variables are displayed in tables with numerical and percentage frequencies and for quantitative variables we obtained the mean and standard deviations. RESULTS: The male sex represented 55.7% of the population; the mean age at diagnosis was 43.27 years. Pituitary adenoma was registered in 83% of the cases. The accompanying symptoms were headache, visual field defects, and arthralgia in 18.2%, 27.3%, and 29.5% of the cases, respectively. 48.9% of cases received surgical treatment. The frequency of hypopituitarism was 38.6%. The frequency of comorbidities was: hypercholesterolemia (36.4%), arterial hypertension (29.5%), hypertriglyceridemia (22.7%), type 2 diabetes mellitus (22.7%) and ventricular hypertrophy (11.4%). CONCLUSION: The average age of patients with acromegaly was 52.60 years, the average age of diagnosis was 43.27 years, and it was more frequent in males. In 83% of the patients it was associated with the presence of pituitary adenoma. The most frequent comorbidity was hypercholesterolemia, in 36.4% of the patients. 48.9% of the patients received surgical treatment, 34.1% received combined treatment. 38.6% patients presented hypopituitarism; no cases of hyperprolactinemia were documented.
Frecuencia de alteraciones en parámetros analíticos de laboratorio en pacientes con VIH en tratamiento con medicamentos antirretrovirales en la Unidad de Infectología del Hospital de Especialidades José Carrasco Arteaga durante el período 2018 - 2019
Authors: Aguirre Ponce Silvia Marcela , Sánchez Jara Pamela Carolina , Vallejo Ramón Arturo Fernando
Published: January 2023

BACKGROUND: According to the WHO, in 2021 there were 28.7 million people infected with HIV in the world under antiretroviral treatment. Although antiretroviral therapy has improved the survival of people with HIV, the adverse effects caused directly or indirectly by antiretroviral therapy have caused poor adherence to it, leading to therapeutic failure. The aim of this study is to determine the frequency of laboratory parameters alterations in HIV patients under treatment with antiretroviral drugs. METHODS: A descriptive, observational and cross-sectional study was carried out. The sample consisted of 233 patients diagnosed with HIV under antiretroviral treatment, treated at the Infectious Diseases Unit of Hospital de Especialidades José Carrasco Arteaga. The analyzed variables were: age, sex, treatment regimen; alterations were sought in the following variables: lymphocyte count, hemoglobin, blood triglycerides, blood glucose, neutrophil count, transaminases, bilirubin, creatinine, urea and lactic acid. RESULTS: The majority of patients were male (86.70%), mainly between 30 and 39 years of age (33.91%). The most used scheme was "Tenofovir + Emtricitabine + Efavirenz" (57.94%). The laboratory analytical alteration presented most frequently in all treatment schemes, except for Tenofovir+ Emtricitabine + Lopinavir+ Ritonavir, was hypertriglyceridemia (25.75%). 24.46% of the patients did not present any analytical alteration. CONCLUSION: The majority of HIV patients during 2018-2019, in HEJCA, were male, between 30 and 39 years of age. The most widely used treatment scheme was "Tenofovir + Emtricitabine + Efavirenz". Hypertriglyceridemia was the most frequent laboratory abnormality, followed by hyperglycemia and anemia. A quarter of the study population did not show any laboratory abnormalities with the prescribed treatment schemes.
Peran Dukungan Sosial Keluarga dan Kemandirian Belajar terhadap Flourishing pada Mahasiswa yang Terancam Drop Out
Authors: Ridha A. Ahmad
Published: January 2023

Flourishing is the highest level of human psychological well-being. Flourish conditions are needed by students who nearly drop out in completing their education at college. This study aims to determine the role of family social support in the flourishing of students who nearly drop out, moderated by independent learning. This study uses a quantitative approach at university X in Tarakan, North Kalimantan. The subjects of this study were 70 students who nearly dropped out. The results of the moderated regression analysis show that family social support and independent learning play a positive role in student flourishing. However, learning independence still needs to be proven to strengthen the role of family social support for flourishing students who nearly drop out. This means that independent learning does not have a significant moderating effect as a moderating variable. Flourishing merupakan tingkatan tertinggi dari kesejahteraan psikologis manusia. Kondisi flourish sangat dibutuhkan mahasiswa yang terancam drop out dalam menyelesaikan pendidikannya di institusi pendidikan. Penelitian ini bertujuan untuk mengetahui peranan dukungan sosial keluarga terhadap flourishing mahasiswa yang terancam drop out yang dimoderatori oleh kemandirian belajar. Penelitian ini menggunakan pendekatan kuantitatif di Universitas X di kota Tarakan, Kalimantan utara. Subjek penelitian ini adalah 70 orang mahasiswa yang terancam drop out. Hasil moderated regression analysis menunjukkan bahwa dukungan sosial keluarga dan kemandirian belajar secara bersama-sama berperan positif terhadap flourishing mahasiswa, namun kemandirian belajar tidak terbukti memperkuat peranan dukungan sosial keluarga terhadap flourishing mahasiswa yang terancam drop out. Ini berarti bahwa kemandirian belajar tidak memiliki efek moderator yang signifikan sebagai variabel moderator
Implementation of Project-Based Learning for Freshmen in Online Learning During COVID-19 Pandemic
Authors: Nasanjargal Battulga , Ganbat Gantuya
Published: January 2023

The engineering project course in the form of project-based learning at GMIT, Mongolia, is adapted from the engineering program at the Technical University of Darmstadt and has been implemented since 2014. The transition from traditional to online learning during COVID-19 pandemic disrupted the engineering education process. Due to COVID-19 pandemic, the engineering project course is conducted online. The current study presents the analysis of questionnaire surveys done during COVID-19 and non-COVID-19 pandemics and discusses the advantages and disadvantages of online learning.
Irrationality of Digital Medicine: VR, IoT and AI in Practice
Authors: Henry Shimo Shimo , Bondareva Inna
Published: January 2023

Artificial Intelligence (AI) has potential to change the tasks that are currently being done by Human being. The Internet of Things (IoT) has potential to increase Medical Device connectivity, enabling more immediate information sharing and coordination between doctors and patients. Virtual reality (VR) has potential to enhance medical training. Digital Health technologies have the power to expand coverage of healthcare (access), enhance services (quality) and reduce/optimize resources (cost). Affordability, infrastructure, and human capability limits overall impacts of Digital Health technologies and must be addressed. Therefore, capacity building through strategic alliances and partnerships remains crucial in harnessing the promises of Digital Health Technologies. This paper summaries challenges in the implementation of Digital health Solutions among African health systems and enumerate the possible ways of addressing the identified challenges.

Keywords— Artificial Intelligence (AI), Internet of Things (IoT), Virtual Reality (VR) Digital Health, Remote Patient Monitoring RPM), Robotic Process Automation (RPA)
Prognosis of Complications at Surgical Treatment of Benign Parotid Tumors
Authors: Iriskulova Elmira , Kodirova Ziyodakhon , Juraboev Sardor
Published: January 2023

The development of clinical medicine to a certain extent depends on the level of prognosis of surgical patients. In prognosis, the method of regression analysis is widely used. Prognostic scales help to assess the risk of complications in patients after surgery, which allows the use of relatively more effective diagnostic and therapeutic measures. The aim of the study was to develop the integral mathematical characteristics of the prognosis of the outcome at surgical treatment of benign parotid tumors, adequately describing the pathological process. When constructing a mathematical prognostic model, its parameters were subject to the requirement of their efficiency above ??95% according to the t-criterion. The purpose of the mathematical modeling was to statistically adequately link the complications of surgical treatment of parotid tumors with clinical and diagnostic data. The developed mathematical model made it possible, on the basis of significant clinical and diagnostic data in patients, to identify prognostic factors for the development of paresis of the mimic muscles of the face in the surgical treatment of benign parotid tumors. Based on the studied correlation analysis, the significant (??0.05) clinical prognostic factors for the development of paresis of the mimic muscles of the face after the operation of partial superficial parotidectomy were revealed: gender, patient’s age, cytological result, sonoelastographic strain-ratio value, computer tomography or magnetic resonance imaging of tumor size. Also, the prognostic factors for the development of paresis of the mimic muscles of the face during the parotidectomy and the extracapsular dissection of the lower pole of the parotid gland were determined. In the result the certificate of the official registration of the computer program was received. The possibility of prognosis of the complications of surgical treatment in patients with parotid tumors has also been developed in order to reasonably carry out more effective therapeutic and rehabilitation measures.
Educational Technologies in Teaching the Subject "Life Safety"
Authors: Kamilova Jamilakhon
Published: January 2023

The article deals with the didactic possibilities of a business game as a means of educational technology. The possibility of using a business game as a form of conducting seminars and practical classes in the study of the discipline "life safety" in higher educational institutions is substantiated. The use of pedagogical technologies allows the teacher to gain new opportunities to influence the traditional learning process and increase its effectiveness. We have applied and analyzed by anonymous questionnaire on the environment of medical students the effectiveness of application in practical classes of business game.
Experience of Project-Based Learning for First-Year Engineering Students at GMIT
Authors: Nasanjargal Battulga , Ganbat Gantuya
Published: January 2023

This study introduces the experience of a project-based learning (PBL) approach for first-year engineering students at German-Mongolian Institute for Resources and Technology (GMIT), Mongolia. The engineering project course at GMIT is the first-ever PBL experience for engineering curriculum in Mongolia and adapted from the engineering program at the Technical University of Darmstadt and has been implemented since 2014. It is dedicated to preparing students for gaining both technical and soft skills through PBL from the beginning of their engineering education. The questionnaire surveys are taken regularly during the course period from students to improve the course quality. The current study presents the analysis of questionnaire surveys done in 2019 and discusses the benefits and challenges of the course. The responses by students revealed that the implementation of the course was beneficial in improving teamwork. Suggestions based on the PBL are given to improve the effectiveness of engineering education in Mongolia.