bluuebunny/crossref_metadata_2025 huggingface dataset:
Accountability of village fund management during the covid-19 pandemic (Study on village government in Dayun District, Siak Regency)
Authors: Purba Sahala , Napitupulu Junika , Siregar Andro
Published: April 2023

This study aims to examine the effect of the competence of village government officials, citizen participation, application of information technology, organizational commitment, transparency, and internal control systems on the accountability of village fund management in village government. This study is a quantitative study using primary data obtained by distributing questionnaires. The analysis method used is multiple linear regression. This study was conducted in 11 villages in Dayun District, Siak Regency, Riau Province, Indonesia.Â  Each village was represented by 4 respondents consisting of the village head, village secretary, financial officer, and 1 member of the Village Consultative Agency (BPD). The research was conducted from April to May 2022. The results show that the competence of village officials, citizen participation, the application of information technology, and internal control systems have an effect on the accountability of village fund management, but organizational commitment and transparency have no effect on the accountability of village fund management. Adequate competence of village officials, high citizen participation, application of good information technology, and application of an appropriate internal control system can increase the accountability of village fund management during the COVID-19 pandemic.
New accounting ideology as the efforts of preventing the fraudulent financial reporting
Authors: Shonhadji Nanang
Published: April 2023

This study aims to conceptualize Â a accounting ideology with a divinity ideology to prevent fraudulent financial reporting. This research is a non-mainstream research with a grounded theory method. Theorizing of new ideological is for building to prevent the fraudulent accounting and financial crime practices. The research site is the practice of financial accounting in Indonesia by utilizing primary data from selected informants. The results show that when accounting is born in a capitalistic environment, the information it conveys is profit-oriented. Then the economic decisions and actions taken are also money oriented. Finally, the reality that is created is the reality to gain profit or money which leads to fraudulent behavior. Therefore we need a concept of accounting ideology that is able to present universal spiritual values to prevent fraudulent financial reporting. This spiritual value were manifested in the reconstruction of the accounting ideology as monotheism, trustworthiness, mashlahah, sincerity, fairness, ihsan, istikhlaf, ukhuwwah, shiddiiq and qanaah which will be the basis for the mindset and behavior of accountants so as not to commit fraudulent financial reporting.
Social Media Marketing Activities Role in Creating Loyalty of Islamic Banks in Indonesia
Authors: Sarassina Fosa
Published: April 2023

The increasing number of social media users in Indonesia highlights the growing importance of social media in fostering loyalty. Despite this, there is a lack of models available for analyzing the complex relationship between Social Media Marketing Activities (SMMAs) and loyalty, and the various mediating variables that impact this relationship. However, the Customer Relationship Quality (CRQ) model has emerged as a promising approach, providing a framework to analyze the impact of SMMAs on loyalty, as well as key mediating variables like trust, satisfaction, and commitment. Despite the strengths of this model, it has not yet explored the direct relationship between SMMAs and loyalty. In response, this study expands on this framework by adding this direct relationship to the model. To collect data, an online survey was used to gather responses from 138 followers of the Facebook and Instagram accounts of the five largest Islamic banks in Indonesia. The resulting data was analyzed using the powerful Structural Equation Modeling (SEM) approach, with the Smartpls software used to examine the complex relationships between variables.
ISLAMIC-ECORELIGIOUS: PRINSIP-PRINSIP TEOLOGIS ISLAM TENTANG ETIKA LINGKUNGAN
Authors: Faiz Fahruddin
Published: April 2023

Environmental Ethics deal with the moral relationship ofhuman beings with the environment. It answers questions like, why is it wrong for humans to pollute and destroy the environment? Is it wrong to pollute the environment because it harms the present or the future of human well-being or because nature itselfpossesses an innate value? The framework of the behavior of Muslims in respect to nature is a very important component in Islamic ethics. Both the Quran and Hadith (Sunna) emphasize protecting and valuing the environment as a central component of faith. Though Islamic ethics is providing Muslims with very sophisticated and just principles; the majority of Muslims are not taking the forefront in protecting nature and in shaping sustainable policy and practices. The aim in this article is to assess the relationship between nature and Islamic ethics and possible Islamic responses to the environmental crisis.
ANTI PARTAI POLITIK ISLAM DALAM PEMIKIRAN NURCHOLIS MADJID
Authors: Azizi Shohibul
Published: April 2023

In 1970, Nurcholish Madjid stated "Islam yes, islamic parties no" within his speech in Menteng Raya Jakarta in the moment of night meeting among the organization of youths, leaners, students, and scholars of moslem coming form HMI (Himpunan Mahasiswa Islam), GPI (Gerakan Pemuda Islam), PII (Pelajar Islam Indonesia) and Persami (Persatuan Sarjana Muslim Indonesia). He is not interested in islamic parties, since the leaders of the islamic parties existing in that time did not became the transmitters ofmoslem community's  aspiration any longer. Instead, they only struggled their parties and their own interests. Beside, they also were devided into different denominations who had no strong commitment to the struggle of moslem community. He asserts his standpoint that his commitment is merely to Islam, not to Islamic institution.
SUFI HEALING PRAKTEK PENGOBATAN SPIRITUAL DI DESA CANGKREP KABUPATEN PURWOREJO
Authors: Nur Syaifan
Published: April 2023

The Sufi healing is an alternative therapy model which is practicing by adopting the practices and values of tasawuf as a medium of healing/anticipation. This therapy is common in the society, i.e. indeveloping Sufism tradition. The practical tasawuf practices, such as sholat, dzikir, tafakur (meditation), are not just rituals without meaning; however, in this Sufi practices, there is healing potencies to the illness that cannot be cured by modem medical world, such as cancer, stroke, many mental and psychological illnesses. The basic principle in the Sufi healing is the cure is only come from Allah the all healer. This writing tries to examine healer practice using Sufi model practicing by Kyai Tamo, a society leader who is active in Sufi world. This kyai who is living in Purworejo tries to introduce tasawuf to society by Sufi healing. This healing practice by Kyai Sutamo seems appealing to society, so that his practical place always filled by patients who are came by many kinds of illnesses
GIBRANISME: ANTARAEKSISTENSIALISME DAN ROMANTISISME
Authors: Faiz Fahruddin
Published: April 2023

Not many in this world there is a person as a philosopher as well as a poet. Among the few of them there is one popular name incontemporary literature's world, i.e. Kahlil Gibran. Many people knew Kahlil Gibran as poet-philosopher from Lebanon resided in Boston, United States. Gibran's thoughts and ideas are very philosophical and full of meaning, since expressed in beautiful poetical style, therefore popular in public. In another side, Gibran's styles are often using parables and aphorisms make people easier to understand even within esoteric and mystical dimension. Inits analysis the writer saw the whole Gibran 's vision and perception towards universal themes in life, including love, it could be said that Gibran is a person with sharp and clear view in perceiving reality around. Even to show the truth ofreality portrait, Gibran does not hesitate to break the common order and the "approved" order, to the minutes details such as the application ofgrammar. This makes Gibran to bear the title The Heretic and The Rebellious. This style is followed and gives inspiration to many writers and another thinker after himself. This Gibran's thought and style to many people are called as Gibranism.
MAKNA BERAGAMA MENURUT IMMANUEL KANT DALAM RELIGION WITHIN THE LIMITS OF REASONALONE
Authors: Iqbal Imam
Published: April 2023

The searching oflmmanuel  Kant's thought in this paper will try to explain his ideas concerning to the meaning of religion from his critical philosophical perspective by set up from his work Religion within the Limits of Reason Alone. That work, will show later, is one of important Kant's work, especially concerning the relation between reason, religion, and morality. Although Religion could be classified as a work in philosophy of religion's field, however Kant's writing style in this work was not in popular fashion as commonly the work in philosophy of religion's field to be written. Kant's views ofreligion and the meaning ofbeing religious in this work are closely related to the moral frame work that he explained in his other works. The writer underlines some important points of Kant's thoughts: First, Religion has showed Kant's interest to religious problems, especially concerning religious meaning, in relation to morality and rationality. Second, the main discussion in Religion is about religious meaning. Third, Kant's explanation to religious meaning in Religion could be traced in to areas, i.e. individual area and social-community area. Fourth, the core of religious meaning in Religion is situated to Kant's implicit invitation to shift from just as ''having religion" to the ''being religious", or from having religious falsely to being religious authentically. Fifth, being religious or to be religious authentically is a representation of critical religious attitude.
Tasawuf Abd Al-Rahman Al-Sulamī (Perspektif Historis)
Authors: Sofiudin Muh
Published: April 2023

Abu Abd al-Rahman Al-Sulamī (d. 412 H) is known as a great Sufi scholar. In the realm of tasawuf, he formulated tasawuf as in al-muqaddimah fi al-tasawwuf and wrote the biographies of the Sufi scholars in his book Thabaqat al-Sufiyyah. The tasawuf review in the form of biography of the Sufi ulama gives a distinctive picture in the process of formulating the concept of tasawuf. On the other hand, although al-Sulamī is known as a tasawuf briliant thinker, in Indonesia, it turns out to be less prestige than his pupil named al-Qusyairi. In fact, al-Sulamī is al-Qusyairi’s teacher who actually has more scientific authority than his pupil. This fact can be caused by many factors, one of which is the lack of information and references to al-Sulamī.
Beragama Di Tengah Badai Kemanusiaan
Authors: Mutiullah Mutiullah
Published: April 2023

Religion is one requirement of human life. Since beginning of life, human needs religion as guide to appoint  the good conditions. It has many contributions to civilizations such as hopefully to save. Also, it gives solving to many human’s problems. Recently, religion has challenging that is to solve many social conflicts as poverty and fundamentalism thoughts. So, what should religion does? There are two answers. The first, religion has to reinterpret his dogma. The second is religion as future ideology must to solve many human problems.
MEMBACA KISAH NABI DAUD MENGGUNAKAN SEMIOTIKA ROLAND BARTHES
Authors: Santoso Jarot Nanang , Abror Indal
Published: April 2023

Roland Barthes’s semiotics, as a science that is concerned in coding, was applied in analyzing the story of the Prophet David. Application of multilevel readings; Heuristic readings and retroactive readings in the story of the Prophet David consisting of 25 lexia texts of the Koran, were found to be of significance identified from certain codes, including: a) hermeunetic code / puzzle code, b) symbolic code “David” symbol from the ideal leader, c) the semic code or the “ark” connotative code means the importance of preserving and preserving relics, d)   the proaretic code / action code “David fell” means humility acknowledging mistakes not looking at someone’s status, e) gnomic code or code Cultural “Goliath and its troops” means that there will always be those who spread damage, and during this time God’s intervention will also contribute to protecting the universe through the other party who spread goodness, and so on.
KALIGRAFI ISLAM DALAM PERSPEKTIF FILSAFAT SENI
Authors: Kirom Syahrul , Hakim Alif Lukmanul
Published: April 2023

This article discusses Islamic calligraphy from the perspective of art philosophy. Islamic calligraphy (the art of letter painting) turns out to have values of beauty, uniqueness and spiritual value and has symbolic meaning for Islamic culture. Calligraphy art has religious spiritual meaning and value that causes a person to experience eschatology. Therefore, in this article the author is interested in analyzing Islamic calligraphy with an art philosophy approach. The method used is descriptiveanalytical. This Arabic calligraphy art writer studies by analyzing through its formal object is the philosophy of art. While the material object is to study the meaning of religious-spiritualism which is more philosophical in understanding Islamic calligraphy. The results of this study found that the fact that the art of Islamic calligraphy has beautiful aesthetic values is full of faith and devotion. The existence of Islamic calligraphy art provides meaning and understanding of the process of achieving a very transcendental idea to God.
KONSEP MAHABBAH JALALUDDIN RUMI
Authors: Octafany Assya
Published: April 2023

This article explores Rumi's mahabbah concept. Currently, in society, the concept of love is degrading in meaning, resulting in its constriction. This is because the concept of mahabbah, which we usually refer to as "love," is unfamiliar to the general population. In general, society equates love with liking the other sex. Spite of the fact ,  Rumi asserts that love is not confined to that. The notion of love will be addressed in this study via the lens of Jalaluddin Rumi, specifically the nature of love and its application in life. The findings of this study provide an outline of the type of love that people should possess: love powerful enough to cause someone to love their god.
KEUNGGULAN METODE DEMONSTRATIF TERHADAP METODE RETORIKA DAN DIALEKTIKA: MENGUAK METODE KRITIK FILSAFAT IBN RUSYD
Authors: Bistara Raha
Published: April 2023

This article shows how the demonstrative method (burhani) is more superior to rhetoric (khatabbi) and dialectic method (jaddali), the use of the demonstrative method is based on the utilization of the mind. Ibn Rusyd stated that the demonstrative method is considered the right method for seeking the answers above the questions on the subject of religion and philosophy. However, it is not amazed Ibn Rusyd used a demonstrative method to criticize the Mutakallimun Ash’ariyah and his followers especially Imam Al-Ghazali. Ibn Rusyd also criticized Ibn sina and Zahiriyah group with the method they used. There was confusion for the answer to who they presented regarding religious and philosophical problems. While there were many problems with their views especially in their books. This article used the library research method which uses literature either in the form of books, or notes from previous research reports. While the sources of this research there are two sources as primary source and secondary sources. This result of this research revealed that Ibn Rushd’s philosophy critical method from authentic sources related to the problem. Although, by the use of  various sources used, it is hoped there will be a new finding related to demonstrative method initiated by Ibn Rushd in refuting the arguments of  rhetorical and dialectical groups which are not deep, explicit, and simple. As well as providing the new formulas that are fresher and more varied concerning the answer about the problems of religion and philosophy.
Analisis Teori Fungsionalisme Struktrual Talcott Person atas Metode Pembagian Waris Adat Berbasis Resolusi Konflik di Desa Jiken Kecamatan Tulangan, Sidoarjo
Authors: Rahman Zayad Abd , Thahir A Halil , Maimunah Dewi Umi
Published: April 2023

This article reviews the reasons for the community and the practice of grants which are calculated as inheritance rights in Jiken Village, Tulangan District, Sidoarjo with the perspective of Talcott Parsons' Structural Functional theory.This study is important because there are many casuistic paradoxical phenomena regarding the distribution of inheritance by parents to their children before death which in the end becomes inheritance, occurs in the people of Jiken Village.This article uses a qualitative approach, the data is collected through interviews as the main instrument.The results of the study revealed that:1) The main reason for this phenomenon is the first concern of inheritance after death, there will be conflicts between heirs.Second, it is fairer if the heir himself distributes it.Third, the traditional factors that support this.2) this phenomenon is in accordance with the characteristics of the Structural Functional theory where the existence of the community agrees on the values and legal norms that apply even though they are not in accordance with the laws and regulations.However, the agreement (customary law) can bring balance, harmony, harmony and social stability that are integrated with each other.The community carried out a movement to free themselves from the distribution of inheritance that was usually used.Then the community will be in the next phase which brings the community to experience social change.
Peran Tasawuf Di Era Masyarakat Modern "Peluang dan Tantangan”
Authors: Falach Ghulam , Assya’bani Ridhatullah
Published: April 2023

This paper will dissect the role of Sufism in the era of modern society. The era of modernity with all its advances, from the outward side, is sufficient for the life of modern society, while from the spiritual side of modern society there is still a drought of spiritual values, such as the loss of morals, mismatches in the application of science and technology, the decline in the quality of faith, individualistic and materialistic attitudes can be resolved with Sufism with using the method. Until now, Sufism is believed to be able to solve various crises of modern society. Therefore Sufism can be used as a means and fulfillment of human needs from the spiritual side. This modernity has also generated industrialization, science, and technology, which have increasingly influenced life, resulting in a shift in patterns and lifestyles, where moral values, ethics, and teachings began to be abandoned because they were deemed incompatible with modern values. At this point, there is a crisis of existence and spiritual aridity. Through the implementation of Sufism in the modern era, it is very much needed by transforming the understanding of Sufism, not only maqamat and awhile, but modifying Sufism in such a way that it becomes dynamic and open so that it is easily understood and practiced by humans in modern times. Sufism as a means to get closer to God is expected to be able to overcome the spiritual crisis because with its values Sufism can provide a balance in human life. From the results of the analysis, it can be seen that Sufism has a breath of fresh air to overcome the various problems of modern society and to balance between lahiriyah and batiniyah. Also, Sufism becomes important for the life of modern society because Sufism can function as a controller and controller of humans so that the human dimension is not reduced by modernization that directs humans to anomalous values so that it will lead humans to the achievement of moral superiority.
Solusi Filsafat Jiwa Sadra Pada Problem Paradoks dan Implikasi Onto-Epistemik Transhumanisme Nick Bostrom
Authors: Rahman Fadhlu
Published: April 2023

This study aims to examine and provide a solution to Nick Bostrom's onto-epistemic theoretical consistency problem of transhumanism which is considered to have a conceptual paradox and its implications for the basic concepts of transhumanism which consists of three pillars, namely: superintelligence, superlongevity, and super wellbeing. The testing and solutions that will be given are carried out through one of the major themes of the discourse on the relation of soul and body and the process of perfection in the tradition of Islamic philosophy. One form of mature philosophical discourse is in the Sadra’s philosophy of Soul. Therefore, the writer wants to describe the ontological and epistemological foundations of Bostrom's transhumanism as well as the Sadra’s philosophy of soul, and look at the paradoxes and onto-epistemic implications of the three pillars of transhumanism based on Sadra's view by descriptive and comparative analysis methods. In previous studies on the issue of transhumanism and the philosophy of the soul, Sadra still only focused on the description of each of these two issues. In addition, the study of this issue (transhumanism) focuses on the problem of its metaphysical basis by a western philosophical approach, so, this study wants to analyze it from the perspective of Islamic philosophy which is considered authoritative as the basis for studying metaphysical issues in the onto-epistemic context of transhumanism. I find that his onto-epistemic assumptions include; first, its dualism of epiphenomenalism as the basis of ontology necessitates the impossibility of matter having direct access to immaterial states of the self, while its limitations cannot create the perfection that Bostrom intended; and the second, his scientism as the basis of his epistemology require perfection that is not comprehensive and holistic, from the results of the analysis, I assesses that Bostrom's metaphysical assumptions are problematic both in terms of coherence and correspondence on the pillars of his transhumanism, and Sadra’s philosophical thought provides a solution in the form of the onto-epistemic basis for his soul philosophy and the process of perfecting in the problem of the fragility of Bostrom's Transhumanism ideas which can then provide the ideal form of the perfect human that Bostrom assumes.
Konsep Kebebasan Kehendak Manusia Sebagai Penentu Hidup Sosial: Studi Analisis Pemikiran Friedrich Nietzsche
Authors: Wafi Hasan Abdul , Firdausiyah Umi Wasilatul
Published: April 2023

The discourse of this research leads to social life, which in Friedrich Nietzsche's perspective is determined from the concept of freedom of human will. The purpose of this research is to examine how the concept of the free will of humans in Friedrich Nietzsche's perspective can be a determinant of human social life itself. The research method used by the author is in the form of philosophical hermeneutics, the type of data collection is documentation, and the data analysis is descriptive-philosophical. The results of this study are in the form of a benchmark for human life that depends on the freedom of human will, with Nietzsche's explanation that human life has a responsive structure that is hidden in the concept of freedom of will. This is what Nietzsche means in the influence of the support of human life. So that human social life will not be separated from human action and will, which is witnessed by consciousness, this also reflects the freedom of human will. In essence, the concept of freedom referred to by Nietzsche has the mission of forming human social life, both in terms of interaction and responsibility for humans themselves.
Tarekat Syadziliyah dalam Dimensi Kesalehan Individual dan Kesalehan Sosial serta Pengaruh Modernisasi dan Globalisasi
Authors: Islamiyati Rosi
Published: April 2023

This study aims to unveil the veil of human existence which is influenced by the currents of modernization and globalization, and its role with God's servants (spiritual beings). The research link in modern humans is an unbalanced self condition. Because modern humans are like machines that are constantly driven by conditions or circumstances. In the study of Sufism, at least this paper tries to answer academic anxiety about the main teachings of the Syadziliyah Order and how to maintain the outer and inner dimensions of modern humans from the influence of modernization and globalization. This research model is based on qualitative with library research data collection methods. While the data processing method uses descriptive-analysis. From the results of the study, it can be concluded that the Tarekat Syadziliyah provides an alternative balance between the worldly and spiritual dimensions, as well as social and individual piety by, first, not recommending to its students to leave the world profession. Second, do not neglect in carrying out Islamic law. Third, zuhud does not mean staying away from and hostile to the world because basically zuhud is a matter of emptying oneself from other than Allah. Fourth, there is no prohibition for the salik to become a millionaire. Fifth, trying to respond to what is currently threatening people's lives, trying to bridge the spiritual drought with world affairs that plague people's lives. Sixth, Sufism is an exercise of the soul in the context of worship and placing oneself in accordance with His provisions. Seventh, as one of the goals of tarekat and Sufism experts, two ways can be obtained, namely: Mawahib or 'ain al-jud, namely the gift that God gives to the servant he wants. Furthermore, makasib or badzi al-majhud, namely ma'rifah, will be obtained when accompanied by hard work through riyadhah, mujahadah, al-dhikr, muladzamah wuhdu, fasting, sunnah prayers.
Perbandingan Konstruktivis dan Parennialis dalam Menjelaskan Pengalaman Mistik
Authors: Ilham Maulana
Published: April 2023

In the discourse of philosophy of mysticism, there are at least two opposing views in explaining the expression of mystical experience, namely constructivist and perennialist. The constructivist views that mystical expression is closely related to the mystical tradition that originates so that the symbols used cannot be separated from tradition. This relates to the cognitive qualities possessed by mystics which shape the reality they find. Meanwhile, the perennialist argues that mystical expressions can be separated from tradition, so mystics often use symbols that are universal and cross-tradition. Discovered reality transcends cognitive influence. This article will analyse the comparison of the two views. The method used in this research is comparative analysis to find a middle ground that the two views are possible to juxtapose. I found a meeting point between the two views is the issue of ineffability or the unspeakable nature which is one of the characteristics of mystical experience. This problem shows that the relationship between experience and understanding in the case of spiritual experience is so complex. There are facts that are experienced but cannot be expressed so that mystics choose to remain silent or make paradoxical expressions. Therefore, the solution given is the ineffability character of mystical experience which cannot be ignored by constructivists and at the same time does not show that mystical experience is a pure experience as perennialist claim.
 Keywords :  Constructivist, ineffability, mystical experience, mystical expression, parennialist
FoMO (Fear of Missing Out) Among Youth Viewed From Herbert Marcuse’s Perspective
Authors: Siti Amallia
Published: April 2023

Following the trend seems to be a benchmark for teenagers in determining the extent of their level of association. To be recognized as slang teenagers, they are not infrequently willing to leave their identity. Excessive anxiety arises when he feels left behind with precious moments that are worldly. This condition is then associated with self-esteem and self-confidence, especially those involving peers. The focus of the study in this research is FoMO behavior(Fear of Missing Out) in adolescents reviewed fromHerbert Marcuse's perspective to find out the fundamental causes behind the anxiety experienced by adolescents due to social media. This research is (Library Research) using several sources such as books, journals and the internet. The methods used include descriptive, analytical, and interpretive methods to connect neo marxism theory with contemporary problems. From the results of the study, it was found that concerns about other people's judgments and good relations with their peers made teenagers lose their original self-identity. The emergence of anxiety that leads to an attitude of insecurity begins to appear when a teenager does not know himself as a whole. Generally, feelings of anxiety in adolescents are related to uploads on social media. Through his analysis, Herbert Marcuse, a neo marxism figure, sees the characteristics of a one-dimensional society that can be related to the FoMO phenomenon among teenagers, namely about false needs and images. Adolescents with FoMO tendencies have difficulty in interpreting themselves in substance. They mostly get stuck at the level of form and follow other people. The orientation of free human beings has deviated far from the order of life. So there needs to be a revolution of thought so that teenagers can better understand how to behave, not just follow trends .
 Keywords :  FoMO, youth, social media, Herbert Marcuse, Marxism
Ivabradine acutely improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy
Authors: Szabo Petra Lujza , Marksteiner Jessica , Ebner Janine , Dostal Christopher , Podesser Bruno K. , Sauer Jakob , Kubista Helmut , Todt Hannes , Hackl Benjamin , Koenig Xaver , Kiss Attila , Hilber Karlheinz
Published: April 2023

The muscular dystrophies caused by dystrophin deficiency, the so‐called dystrophinopathies, are associated with impaired cardiac contractility and arrhythmias, which considerably contribute to disease morbidity and mortality. Impaired Ca handling in ventricular cardiomyocytes has been identified as a causative factor for complications in the dystrophic heart, and restoration of normal Ca handling in myocytes has emerged as a promising new therapeutic strategy. In the present study, we explored the hypothesis that ivabradine, a drug clinically approved for the treatment of heart failure and stable angina pectoris, improves Ca handling in dystrophic cardiomyocytes and thereby enhances contractile performance in the dystrophic heart. Therefore, ventricular cardiomyocytes were isolated from the hearts of adult dystrophin‐deficient DMDmdx rats, and the effects of acutely applied ivabradine on intracellular Ca transients were tested. In addition, the drug's acute impact on cardiac function in DMDmdx rats was assessed by transthoracic echocardiography. We found that administration of ivabradine to DMDmdx rats significantly improved cardiac function. Moreover, the amplitude of electrically induced intracellular Ca transients in ventricular cardiomyocytes isolated from DMDmdx rats was increased by the drug. We conclude that ivabradine enhances Ca release from the sarcoplasmic reticulum in dystrophic cardiomyocytes and thereby improves contractile performance in the dystrophic heart.
PI3K/AKT/mTOR pathway and its related molecules participate in PROK1 silence-induced anti-tumor effects on pancreatic cancer
Authors: Wang Feng , Yan Xiaogang , Hua Yongqiang , Song Jianjun , Liu Di , Yang Chun , Peng Fei , Kang Fuping , Hui Yongfeng
Published: April 2023

The PI3K/AKT/mTOR (phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin) pathway can be initiated by PROK1 (prokineticin 1), but its effect and mechanism of action in pancreatic carcinoma (PC) are not fully understood. In this study, we elucidated the roles of PROK1 and its related molecules in PC in vivo. PANC-1 cells with PROK1 knockdown were injected into BALB/c nude mice. The growth and weight of the tumor were monitored and measured, which was followed by TUNEL (terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling), immunohistochemical staining, and hematoxylin and eosin staining. The key proteins related to proliferation, apoptosis, and the PI3K/AKT/mTOR pathway were determined by Western blotting. We also used public databases to identify the molecules related to PROK1. The reduction of PROK1 inhibited angiopoiesis and promoted apoptosis in vivo. PCNA-1, cyclin D1, and Bcl-2 decreased considerably, while Bax and cleaved caspase-3 increased significantly after PROK1 inhibition. The PI3K/AKT/mTOR signal inhibition was also closely associated with PROK1 knockdown. The possible related molecules of PROK1, such as von Willebrand factor, were screened and considered to be involved in the aberrant activation of PI3K/AKT. In conclusion, PROK1 knockdown significantly prevented tumor growth and promoted apoptosis of human PC cells in vivo, where the PI3K/AKT/mTOR pathway was probably inhibited. Therefore, PROK1, along with its related molecules, might be important targets for PC therapy.
The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy
Authors: Xin Yanbao , Lin Guojiao , Hua Tianbao , Liang Jianmin , Sun Tianmeng , Wu Xuemei
Published: April 2023

The cytoskeleton plays an important role in epilepsy; however, the mechanism is unknown. Therefore, this study aimed to reveal the mechanism of cytoskeletal proteins in epilepsy by investigating the expression of cytoskeletal proteins and synaptophysin (SYP) in mice at 0, 3, 6, and 24 h, 3 days, and 7 days in a kainic acid (KA)-induced epileptic model. Our results demonstrated that the expression of F-actin decreased significantly between 3 and 6 h, 6 and 24 h, and 24 h and 3 days (P < 0.05). Meanwhile, the expression of the neurofilament light chain, neurofilament medium chain, and neurofilament heavy chain subunits was significantly decreased (P < 0.001) at 3 h after the KA injection compared to the KA 0 h group, followed by an elevation at 6 h and a further decrease at 24 h compared to at 6 h. SYP expression was significantly decreased between 0 and 3 h as well as between 3 and 6 h (P < 0.05). At 24 h, the level was increased compared to at 6 h and continued to increase at 3 days after the KA injection. Thus, we propose that cytoskeletal proteins may be involved in the pathogenesis of epilepsy.
Highly sensitive tandem mass spectrometric measurement of serum estradiol without derivatization and pediatric reference intervals in children and adolescents
Authors: Di Meo Ashley , Yazdanpanah Mehrdad , Higgins Victoria , Nichols Matthew , Bohn Mary Kathryn , Tan Agnes , Zainab Shazina , Sepiashvili Lusia , Adeli Khosrow
Published: April 2023

Objectives

Monitoring estradiol (E2) is important for determining the onset of pubertal development as well as in the evaluation of girls with precocious puberty. However, E2 measurement remains an analytical challenge in children, who have lower circulating levels. We developed and evaluated a simple and sensitive LC-MS/MS procedure for serum E2 quantification in pediatric populations and established age- and sex-specific pediatric reference intervals.

Methods

Residual patient serum samples were used to evaluate the analytical performance of our in-house LC-MS/MS E2 assay. The evaluation included accuracy, precision, linearity, functional sensitivity (LLoQ), and method comparison. Age- and sex-specific pediatric E2 reference intervals were also established from a cohort of 405 healthy children (birth to 18 years) recruited with informed consent. Age- and sex-specific differences were assessed, and outliers were removed. Reference intervals were established using the robust method.

Results

The assay imprecision was <5.3 %. Assay linearity ranged from 13.7 to 1923.3 pmol/L. The LLoQ corresponding to a CV of 20 % was determined to be 8.9 pmol/L. Bland-Altman analysis revealed a mean bias of 29.3 pmol/L or 9.1 % between our LC-MS/MS E2 assay and an external reference laboratory measuring E2 by LC-MS/MS.

Conclusions

Our LC-MS/MS E2 assay shows acceptable accuracy, precision, functional sensitivity (LLoQ), and linearity for E2 quantification. Our LC-MS/MS E2 assay also showed good agreement with an external reference laboratory measuring E2 by LC-MS/MS. In addition, using CALIPER samples, we established robust age- and sex-specific pediatric E2 reference intervals to improve accuracy of test result interpretation and clinical decision making.
Mutually Orthogonal Latin Squares as Group Transversals
Authors: Pradhan Rohitesh , Jain Vivek Kumar
Published: April 2023

In this paper, we give a method to determine a complete set of mutually orthogonal Latin squares of order m, where m is an odd prime or power of a prime, as a group transversal of a Frobenius group.
High stability with low polarization and confinement loss based new structure of photonic crystal fiber waveguide profile
Authors: Zuhayer Asif , Reddy Mittamidi Madhusudhan , Kak Anwer Twana Mohammed , Ahammad Shaik Hasane , Inthiyaz Syed , Hossain Md. Amzad , Rashed Ahmed Nabih Zaki , Hakim Rabab , Daher Malek G. , Zyoud Samer H.
Published: April 2023

Nowadays ethanol is broadly used chemical item in various industrial purpose. So, detection of this organic chemical has become very important task in industrial basis. In this paper, a hexagonal core PCF has constructed in which silica is used as base material. A finite element method is applied and mesh analysis has been done for investigating boundary conditions of proposed PCF sensor. After simulation, 59.48 % sensitivity and an ignorable loss of confinement which is 8·956020 × 10−13 cm−1 at 2.5 THz frequency has been gained. Focusing on easy construction of fiber, conventional fabrication procedures are attainable. Having satisfactory waveguiding attributes, the proposed sensor can be applicable effectively for sensing ethanol and also polarization-based applications of terahertz waves.
Optical communications with guided wave fibers with rectangular cladding for fuel adulteration detection
Authors: Ferdous A. H. M. Iftekharul , Reddy Mittamidi Madhusudhan , Anwer Twana Mohammed Kak , Anower Md. Shamim , Jain Prince , Musha Ahmmad , Islam Md. Ariful , Ahammad Shaik Hasane , Hossain Md. Amzad , Rashed Ahmed Nabih Zaki , Ibrahim Hassan
Published: April 2023

Fuel quality has a significant impact on the lifespan and smooth operation of petroleum engines. Many dishonest merchants mix lower priced oil/ingredients with petroleum products to increase their profit. To solve this problem, a terahertz waveguide-based fuel adulteration sensor that can detect the presence of kerosene in gasoline is proposed. The design procedure is performed by large elliptical hollow core photonic crystal fiber including rectangular cladding. In our study, the used sensor’s performance is investigated and FEM is also used for performing numerical analysis. Our used sensor achieved a maximum 80.34% sensitivity with a negligible total loss having 3.74 × 10−2 cm−1 during 2.8 THz optimum operating frequency conditions which are very impressive. Additionally, under ideal circumstances, the used sensor attained a sound birefringence of 0.01 and 0.034 ranging numerical aperture. The proposed sensor’s structure is quite simple which might make the fabrication process easy. Furthermore, because of the higher sensitivity and guiding properties, the sensor will be an important part of real-life applications in the forthcoming years.
Yiyang Xiang vowel quality: Comparability across two recording media
Authors: Sevilla Robert Marcelo
Published: April 2023

Current events have necessitated the sacrifice of some degree of recording quality in order to reach inaccessible or faraway areas; for instance, using video conferencing software like Zoom for recording rather than traditional in-person microphone or sound booth recording. This then leads to the question: can Zoom-recorded data be used more or less interchangeably with standard recording procedures? The present research is an analysis of vowel acoustics in the Yiyang dialect of Xiang (Sinitic), comparing across two recording mediums: one online (Zoom) and another in person (sound booth). Researching Xiang varieties has been made increasingly difficult during the pandemic. This study analyzes two recordings retelling the events of the Pear Stories video, performed by a speaker of Yiyang Xiang (female, 24, college-educated), one recorded in the sound booth at the University of Hong Kong and another recorded through Zoom using a laptop microphone. Acoustic features analyzed include F1, F2, and F3. Preliminary findings suggest that while F1 is fairly comparable between the two recordings, the higher two formants are altered in ways that question the comparability of Zoom-recorded versus sound booth-recorded vowels. However, results improve considerably if formants are collected manually, suggesting that some recoverability is possible.
Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
Authors: Hu Xue , Guo Baoliang , Sun Tong , Wang Wan
Published: April 2023

Considering the role of glycolysis inhibition as a novel therapeutic strategy for cancer, including breast cancer (BC), we wondered whether glycolysis could affect BC progression by regulating transmembrane O-mannosyltransferase-targeting cadherins 3 (TMTC3). Following the intervention, lactic acid production in BC cells was monitored, and viability, proliferation, and apoptosis assays were performed. The expressions of TMTC3 and endoplasmic reticulum (ER) stress- and apoptosis-related factors Caspase-12, C/EBP homologous protein (CHOP), glucose-regulated protein 78 (GRP78), B-cell lymphoma-2 (Bcl-2), and Bcl-2 associated X (Bax) were quantified. TMTC3 was lowly expressed in BC tissue and cell. The promotion of glycolysis via glucose represses TMTC3 expression and apoptosis yet enhances lactic acid production and growth of BC cell, along with promoted levels of Caspase-12, CHOP, GRP78, and Bcl-2 yet repressed level of Bax, while the contrary results were evidenced after 2-deoxyglycouse intervention. Overexpressed TMTC3 additionally abrogated the effects of glycolysis on increasing the viability and proliferation yet inhibiting the apoptosis of BC cells, with the increased expressions of Caspase-12, CHOP, and GRP78, and Bcl-2 yet decreased level of Bax. Collectively, inhibiting glycolysis restrained the growth and attenuated the ER stress of BC cell by regulating TMTC3.
Effect of calcium on niobium solubility in alkaline solutions
Authors: Ohira Saki , Abe Takeyasu , Iida Yoshihisa
Published: April 2023

The solubility of niobium-94 (94Nb) in calcium alkaline solutions is one of the important parameters in safety assessment of intermediate-depth disposal which are assumed to use cementitious materials. Nb solubility and solubility-limiting solid phases of Nb in these systems remain unclear. The oversaturation solubility experiments were performed systematically in the 0.001–0.1 mol dm−3 (M) CaCl2 solutions under alkali conditions, and the characterization of precipitated solid phase controlling Nb solubility was conducted. The negative dependence of Nb solubilities on pH and calcium (Ca) concentration was observed in solubility experiments, and the Ca/Nb molar ratio of precipitated solid phase was 0.66. The pH and Ca dependence of Nb solubilities was reproduced by the reaction with Nb aqueous species Nb(OH)6
− and Ca–Nb oxide with the Ca/Nb ratio of 0.66, e.g., Ca4Nb6O19 (am). With increasing pH, Nb concentrations in the 0.001–0.1 M CaCl2 solutions were significantly lower than those calculated from thermodynamic data without Ca–Nb solid. This work provides systematic evidence that the presence of Ca clearly affects Nb solubility. Since calcium is a major component of groundwater and cement pore water, the Ca–Nb solid phase should be considered in the Nb solubility assessment.
A review of the photochromic behavior of metal complexes embedded in conjugated (–N=N–C=N–) and non-conjugated azo-imine-based ligands
Authors: Mandal Paritosh , Pratihar Jahar Lal
Published: April 2023

Photochromic compounds are well known and attract tremendous necessity for their versatile applications in various fields of science. When exposed to light, metal complexes containing potentially photoswitchable azo (–N=N–) and imine (–C=N–) based ligands can be switched between trans (E) and cis (Z) two isomers, as well as energy manipulation and energy level modulation. Then the cis (Z) isomers underwent slow thermal isomerization back to the more stable trans (Z) isomers. The quantum efficiency of metal complexes has been tuned by modifying the ligands’ structures and altering metal substrates. Herein our review encompasses the photochromic behavior of a few conjugated azo-imine (–N=N–C=N–), ligands such as arylazoimidazoles, phenylazopyridine, azobispyridine, arylazopyrozoles, as well as a few non-conjugated azo-imine or Schiff base ligands with their metal complexes.
Recitative Voice: Reading Silently and Aloud, with Jean-Luc Nancy
Authors: Puranen Joni P.
Published: April 2023

This text studies the corporeality of attentive reading. It relies and builds upon philosopher Jean-Luc Nancy’s suggestion that there is, each time, arecitative voicewithin the heart of our advancement through a textual body. This text examines the intriguing figure of recitative voice by paying attention to two bodily variations of reading: reading aloud and reading silently. Nancy’s recitative voice, as a sonorous, resonant, oral, buccal and vocal notion, can help us in explicating how our bodies condition our experiences of reading, yet ultimately he remains rather implicit on how we advance through textual bodies. This short text argues that we can explicate the bodily weight implicit to reading, if we interpreted it as a recitative act. When we read aloud, our experience of a text consists of an advancement of our conjoined gaze and voice through the letters, words and sentences making up our text; when we read silently, our closed and silent mouth is still conjoined with our advancing gaze, advancing as desirous for speech and with words already grasped, even when no words are folded in (or with) exhaled warm air.
Synthesizes of graphene oxide grafted with chitosan and copper oxide nanoparticles for the removal of lambda-cyhalothrin and thiamethoxam insecticides from wastewater
Authors: Khawaja Heena , Zahir Erum , Asghar Muhammad Asif , Daniel Asher Benjamin
Published: April 2023

The residue of lambda-cyhalothrin (LCT) and thiamethoxam (TMX) insecticides are toxic systemic pyrethroid and neonicotinoid insecticides and their entrance into water bodies can have a toxic impact on aquatic and terrestrial life. Therefore, producing of economical, sustainable and effective adsorbents is immediately required for the removal of these insecticides from polluted water. In this study, the nanocomposite of graphene oxide (GO) grafted with chitosan (CS) and copper oxide nanoparticles (Cu-NPs) was synthesized, characterized and assessed, for the first time, for LCT and TMX removal from wastewater using sorption and mechanism studies. The removal of LCT and TMX was assessed by varying the adsorbent dose, initial concentrations of insecticides, pH, exposure time and temperature to achieve optimum sorption conditions. The nanocomposite provides more than 80% removal rate for 1400 mg/L of insecticides in an aqueous solution using only 100 mg of nanocomposite at 318 K in 120 min due to large surface area and pore volume. The adsorption equilibrium data best followed the Langmuir model, with an adsorption capacity of 153 and 193 mg/g for the LCT and TMX, respectively. The pseudo-second-order explained the kinetics best, and the thermodynamic study indicated that the process was spontaneous, and endothermic and proceeded with the increase in randomness. The suggested mechanisms of LCT and TMX sorption by GO-CS-Cu nanocomposite are hydrogen bonding and electrostatic attraction. The reusability study of GO-CS-Cu was executed up to five cycles and maintains its efficiency even after the considered cycles. In conclusion, the study proves the promising use of GO-CS-Cu as a stable, reusable and promising adsorbent for LCT and TMX removal from wastewater at the industrial level.