bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF EFFORT-REWARD IMBALANCE ON TURNOVER INTENTION MEDIATED BY BURNOUT AND WORK STRESS IN CONTRACT NURSES
Authors:   STIE Amkop Makassar, Kurniawaty Kurniawaty , Tawil Muhamad Risal ,   Politeknik Baubau
Published: October 2023

This paper is motivated by the increasing number of nurse turnover at Bahteramas Hospital over the past 3 years. This incident is caused by factors that cannot be explained. In addition, there are inconsistencies in the findings of previous studies in the effect of effort-reward imbalance on turnover intention where one researcher and another researcher did not reach the same conclusion. This study will examine the model of the effect of effort-reward imbalance on turnover intention by presenting burnout and work stress as mediation. Therefore, this study aims to develop a model to analyze the effect of effort-reward imbalance on turnover intention mediated by burnout and work stress. The study was conducted with a quantitative approach and descriptive design utilizing the conservation of resources (COR) theory paradigm which is proven to be able to overshadow all research constructs. The respondents of the study were contract nurses at the Bahteramas Regional General Hospital in Kendari City, while data collection was carried out with digital instruments in the form of a google form that was distributed and managed to collect a sample of 125 respondents using the Slovin formula which was drawn by simple random sampling. The measurement scale is an ordinal scale. The analysis techniques in this study are descriptive statistics and multivariate analysis with the help of AMOS software.The results of the study proved that mediating variables in the form of burnout and work stress were the main triggers that caused turnover intention in contract nurses at the Bahteramas Regional General Hospital in Kendari City. The implications of this study can be used by hospital management to reduce burnout and work stress of contract nurses so that the presence of turnover intention can be avoided.
EXAMINING PURCHASE INTENTION OF PRIVATE-LABEL BRANDS: THE MODERATING EFFECT OF BRAND CATEGORY
Authors:   Universitas Indonesia, Andarini Effly Juvita , Alversia Yeshika ,   Universitas Indonesia
Published: October 2023

Private label is seen as a way to maintain profits, encourage consumption, and as a form of CSR for retail companies when empowering local small businesses. In its development, private labels have evolved into brands that pay attention to value and sustainability. A brand category in Indonesia involves SMEs as product suppliers for PLB. This study examines the influence of factors related to the store on the perception of private-label products produced by SMEs. This study collects online data from 441 Indonesian respondents who are Alfamart and Indomaret customers aged 18 or above and have shopped in the last 3 (three) months, using the non-probability sampling method with a purposive sampling technique. The collected data were tested using SEM Partial Least Squares analysis. The results reflect that store loyalty and brand image have a significant positive impact on attitudes toward buying private labels. In contrast, store loyalty and price consciousness have the least significant positive impact. On the other hand, perceived risk was was found to have a significant negative effect. The Brand Category was found to be moderating in Store Loyalty and Brand Image antecedent variables. This study is expected to be useful for academics and marketing practitioners by expanding private-label studies, especially in relation to SMEs as producers. Moreover, retailers can consider involving more SMEs in their private-label business, which will positively impact society.
Reciprocal Influences in a Duo of Artefacts
Authors: Güneş Canan
Published: October 2023

The combined use of a physical pedagogical artefact and its digital counterpart is described as a duo of artefact. In the literature, duos of artefacts are mostly presented with a certain order: non-digital artefact is followed by the digital counterpart. This study examines the influence of reciprocal use of artefacts in a duo on a 5-year-old child’s identification of multiplicative relationships between the objects. Data is created through the video record of two clinical interviews with the child. The results showed that the reciprocal use of the artefacts enriched the child’s experiences of each artefact and mediated the relationships which were important for multiplicative thinking.
II Congreso internacional liderazgo estratégico y gestión del talento humano: Liderazgo y gestión del talento humano en la cuarta revolución industrial
Authors: Díaz-Sánchez Sandra Ximena
Published: October 2023

El tránsito a la Cuarta Revolución Industrial ha traído consigo transiciones importantes centradas en el individuo como epicentro de las relaciones, de la rentabilidad a toda costa a la prosperidad colectiva, del yo al nosotros en función de la colaboración, del informar al aprender, entre otras, y por ello, a la imperiosa necesidad de construir organizaciones más incluyentes y sociedades más justas. En ese orden de ideas, debatir cuál es el futuro del trabajo, qué nuevas variables entran en juego para la toma de decisiones estratégicas y bajo qué estilos de liderazgo han de afrontarse las oportunidades que conlleva esta nueva época, son las preguntas que se hacen a las comunidades académicas desde la Maestría en Liderazgo Estratégico y Gestión Humana de la ESMIC, hacia la reflexión, el análisis científico y el debate abierto para aportar ideas, herramientas y nuevas prácticas a quienes en todos los sectores de la economía, de los entes gubernamentales y del ámbito militar tienen la responsabilidad de instrumentalizar este cambio de época. Todo ello abordado en el II Congreso Internacional en Liderazgo Estratégico y Gestión del Talento Humano. Liderazgo y gestión del talento humano en la cuarta revolución industrial.
Rozwój społeczno-gospodarczy a racjonalność globalna – w kierunku gospodarki umiaru
Authors: Banaszyk Piotr , Borusiak Barbara , Fiedor Bogusław , Gorynia Marian , Słodowa-Hełpa Małgorzata
Published: October 2023

W artykule przedstawiono trzy grupy celów. Pierwsza odnosi się do sporządzenia diagnozy wpływu procesów wzrostu gospodarczego i rozwoju społeczno-gospodarczego na środowisko naturalne. Druga obejmuje zarysowanie ujęcia normatywnego idei racjonalności globalnej, gospodarki umiaru i dobra wspólnego. W trzeciej grupie celów uwaga jest skupiona na zdefiniowaniu zaleceń dla polityki gospodarczej w świetle przeprowadzonej diagnozy i zaproponowanego podejścia normatywnego. Główną metodą wykorzystaną w opracowaniu jest krytyczna analiza literatury przedmiotu. Słowa kluczowe: rozwój społeczno-gospodarczy, trwały rozwój gospodarczy, racjonalność globalna, gospodarka umiaru, dobro wspólne
Machine Learning Models for Blood Glucose Level Prediction in Patients With Diabetes Mellitus: Systematic Review and Network Meta-Analysis
Authors: Liu Kui , Li Linyi , Ma Yifei , Jiang Jun , Liu Zhenhua , Ye Zichen , Liu Shuang , Pu Chen , Chen Changsheng , Wan Yi
Published: October 2023

Background

Machine learning (ML) models provide more choices to patients with diabetes mellitus (DM) to more properly manage blood glucose (BG) levels. However, because of numerous types of ML algorithms, choosing an appropriate model is vitally important.

Objective

In a systematic review and network meta-analysis, this study aimed to comprehensively assess the performance of ML models in predicting BG levels. In addition, we assessed ML models used to detect and predict adverse BG (hypoglycemia) events by calculating pooled estimates of sensitivity and specificity.

Methods

PubMed, Embase, Web of Science, and Institute of Electrical and Electronics Engineers Explore databases were systematically searched for studies on predicting BG levels and predicting or detecting adverse BG events using ML models, from inception to November 2022. Studies that assessed the performance of different ML models in predicting or detecting BG levels or adverse BG events of patients with DM were included. Studies with no derivation or performance metrics of ML models were excluded. The Quality Assessment of Diagnostic Accuracy Studies tool was applied to assess the quality of included studies. Primary outcomes were the relative ranking of ML models for predicting BG levels in different prediction horizons (PHs) and pooled estimates of the sensitivity and specificity of ML models in detecting or predicting adverse BG events.

Results

In total, 46 eligible studies were included for meta-analysis. Regarding ML models for predicting BG levels, the means of the absolute root mean square error (RMSE) in a PH of 15, 30, 45, and 60 minutes were 18.88 (SD 19.71), 21.40 (SD 12.56), 21.27 (SD 5.17), and 30.01 (SD 7.23) mg/dL, respectively. The neural network model (NNM) showed the highest relative performance in different PHs. Furthermore, the pooled estimates of the positive likelihood ratio and the negative likelihood ratio of ML models were 8.3 (95% CI 5.7-12.0) and 0.31 (95% CI 0.22-0.44), respectively, for predicting hypoglycemia and 2.4 (95% CI 1.6-3.7) and 0.37 (95% CI 0.29-0.46), respectively, for detecting hypoglycemia.

Conclusions

Statistically significant high heterogeneity was detected in all subgroups, with different sources of heterogeneity. For predicting precise BG levels, the RMSE increases with a rise in the PH, and the NNM shows the highest relative performance among all the ML models. Meanwhile, current ML models have sufficient ability to predict adverse BG events, while their ability to detect adverse BG events needs to be enhanced.

Trial Registration

PROSPERO CRD42022375250; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=375250
Caregivers’ Perceptions, Needs, and Data Sharing Concerns in mHealth Research on Pediatric Asthma: Cross-Sectional Survey Study
Authors: Meng Glen , Jan Ali Maliha , Tse Sze Man
Published: October 2023

Background

Pediatric asthma is the most common chronic respiratory disease of childhood. Caregivers often report lacking knowledge in several aspects of asthma management at home. Although the use of mobile health (mHealth) tools, such as mobile apps, could facilitate asthma self-management and, simultaneously, the collection of data for research, few studies have explored the features that caregivers would like to see in such a tool and their perceptions on data sharing.

Objective

This study evaluates caregivers’ perceived knowledge gaps in asthma management; their perceptions of certain features and resources that should be included in a potential mobile app; and any concerns that they may have regarding data sharing for research, including privacy and security concerns.

Methods

In this cross-sectional study, we surveyed 200 caregivers of children (aged 1-13 y) with asthma who were followed at a pediatric tertiary care center in Montreal, Canada. Anonymous data were collected through the institutional web-based survey platform. We collected the participants’ answers by using a 5-category Likert scale (“completely agree,” “agree,” “neither agree nor disagree,” “disagree,” and “completely disagree”), multiple-choice questions, and free-text questions on the abovementioned topics. Descriptive statistics were performed, and answers were compared between caregivers of preschool-aged children and caregivers of school-aged children.

Results

Participating children‘s mean age was 5.9 (SD 3.4) years, with 54% (108/200) aged ≤5 years and 46% (92/200) aged >6 years. Overall, caregivers reported having adequate knowledge about asthma and asthma self-management. Nonetheless, they identified several desirable features for a mobile app focused on asthma self-management. The most frequently identified features included receiving alerts about environmental triggers of asthma (153/199, 76.9%), having videos that demonstrate symptoms of asthma (133/199, 66.8%), and being able to log children’s asthma action plans in the app (133/199, 66.8%). Interestingly, more caregivers of preschool-aged children preferred textual information when compared to caregivers of school-aged children (textual information for explaining asthma: P=.008; textual information for the symptoms of asthma: P=.005). Caregivers were generally highly in favor of sharing data collected through a mobile app for research.

Conclusions

Caregivers of children with asthma in our study identified several desirable educational and interactive features that they wanted to have in a mobile app for asthma self-management. These findings provide a foundation for designing and developing mHealth tools that are relevant to caregivers of children with asthma.
Coagulation Management of Critically Bleeding Patients With Viscoelastic Testing Presented as a 3D-Animated Blood Clot (The Visual Clot): Randomized Controlled High-Fidelity Simulation Study (Preprint)
Authors: Castellucci Clara , Malorgio Amos , Budowski Alexandra Dinah , Akbas Samira , Kolbe Michaela , Grande Bastian , Braun Julia , Noethiger Christoph B , Spahn Donat R , Tscholl David Werner , Roche Tadzio Raoul
Published: October 2023

BACKGROUND

Guidelines recommend using viscoelastic coagulation tests to guide coagulation management, but interpreting the results remains challenging. Visual Clot, a 3D animated blood clot, facilitates interpretation through a user-centered and situation awareness–oriented design.

OBJECTIVE

This study aims to compare the effects of Visual Clot versus conventional viscoelastic test results (rotational thrombelastometry [ROTEM] temograms) on the coagulation management performance of anesthesia teams in critical bleeding situations.

METHODS

We conducted a prospective, randomized, high-fidelity simulation study in which anesthesia teams (consisting of a senior anesthesiologist, a resident anesthesiologist, and an anesthesia nurse) managed perioperative bleeding scenarios. Teams had either Visual Clot or ROTEM temograms available to perform targeted coagulation management. We analyzed the 15-minute simulations with post hoc video analysis. The primary outcome was correct targeted coagulation therapy. Secondary outcomes were time to targeted coagulation therapy, confidence, and workload. In addition, we have conducted a qualitative survey on user acceptance of Visual Clot. We used Poisson regression, Cox regression, and mixed logistic regression models, adjusted for various potential confounders, to analyze the data.

RESULTS

We analyzed 59 simulations. Teams using Visual Clot were more likely to deliver the overall targeted coagulation therapy correctly (rate ratio 1.56, 95% CI 1.00-2.47; P=.05) and administer the first targeted coagulation product faster (hazard ratio 2.58, 95% CI 1.37-4.85; P=.003). In addition, participants showed higher decision confidence with Visual Clot (odds ratio 3.60, 95% CI 1.49-8.71; P=.005). We found no difference in workload (coefficient –0.03, 95% CI –3.08 to 2.88; P=.99).

CONCLUSIONS

Using Visual Clot led to a more accurate and faster-targeted coagulation therapy than using ROTEM temograms. We suggest that relevant viscoelastic test manufacturers consider augmenting their complex result presentation with intuitive, easy-to-understand visualization to ease users’ burden from unnecessary cognitive load and enhance patient care.
An Evidence-Based Framework for Creating Inclusive and Personalized mHealth Solutions—Designing a Solution for Medicaid-Eligible Pregnant Individuals With Uncontrolled Type 2 Diabetes (Preprint)
Authors: Fareed Naleef , Swoboda Christine , Wang Yiting , Strouse Robert , Hoseus Jenelle , Baker Carrie , Joseph Joshua J , Venkatesh Kartik
Published: October 2023

UNSTRUCTURED

Mobile health (mHealth) apps can be an evidence-based approach to improve health behavior and outcomes. Prior literature has highlighted the need for more research on mHealth personalization, including in diabetes and pregnancy. Critical gaps exist on the impact of personalization of mHealth apps on patient engagement, and in turn, health behaviors and outcomes. Evidence regarding how personalization, engagement, and health outcomes could be aligned when designing mHealth for underserved populations is much needed, given the historical oversights with mHealth design in these populations. This viewpoint is motivated by our experience from designing a personalized mHealth solution focused on Medicaid-enrolled pregnant individuals with uncontrolled type 2 diabetes, many of whom also experience a high burden of social needs. We describe fundamental components of designing mHealth solutions that are both inclusive and personalized, forming the basis of an evidence-based framework for future mHealth design in other disease states with similar contexts.
Democratizing Artificial Intelligence Imaging Analysis With Automated Machine Learning: Tutorial (Preprint)
Authors: Thirunavukarasu Arun James , Elangovan Kabilan , Gutierrez Laura , Li Yong , Tan Iris , Keane Pearse A , Korot Edward , Ting Daniel Shu Wei
Published: October 2023

UNSTRUCTURED

Deep learning–based clinical imaging analysis underlies diagnostic artificial intelligence (AI) models, which can match or even exceed the performance of clinical experts, having the potential to revolutionize clinical practice. A wide variety of automated machine learning (autoML) platforms lower the technical barrier to entry to deep learning, extending AI capabilities to clinicians with limited technical expertise, and even autonomous foundation models such as multimodal large language models. Here, we provide a technical overview of autoML with descriptions of how autoML may be applied in education, research, and clinical practice. Each stage of the process of conducting an autoML project is outlined, with an emphasis on ethical and technical best practices. Specifically, data acquisition, data partitioning, model training, model validation, analysis, and model deployment are considered. The strengths and limitations of available code-free, code-minimal, and code-intensive autoML platforms are considered. AutoML has great potential to democratize AI in medicine, improving AI literacy by enabling “hands-on” education. AutoML may serve as a useful adjunct in research by facilitating rapid testing and benchmarking before significant computational resources are committed. AutoML may also be applied in clinical contexts, provided regulatory requirements are met. The abstraction by autoML of arduous aspects of AI engineering promotes prioritization of data set curation, supporting the transition from conventional model-driven approaches to data-centric development. To fulfill its potential, clinicians must be educated on how to apply these technologies ethically, rigorously, and effectively; this tutorial represents a comprehensive summary of relevant considerations.
Digital Phenotyping for Real-Time Monitoring of Nonsuicidal Self-Injury: Protocol for a Prospective Observational Study (Preprint)
Authors: Ahn Chan-Young , Lee Jong-Sun
Published: October 2023

BACKGROUND

Nonsuicidal self-injury (NSSI) is a major global health concern. The limitations of traditional clinical and laboratory-based methodologies are recognized, and there is a pressing need to use novel approaches for the early detection and prevention of NSSI. Unfortunately, there is still a lack of basic knowledge of a descriptive nature on NSSI, including when, how, and why self-injury occurs in everyday life. Digital phenotyping offers the potential to predict and prevent NSSI by assessing objective and ecological measurements at multiple points in time.

OBJECTIVE

This study aims to identify real-time predictors and explain an individual’s dynamic course of NSSI.

METHODS

This study will use a hybrid approach, combining elements of prospective observational research with non–face-to-face study methods. This study aims to recruit a cohort of 150 adults aged 20 to 29 years who have self-reported engaging in NSSI on 5 or more days within the past year. Participants will be enrolled in a longitudinal study conducted at 3-month intervals, spanning 3 long-term follow-up phases. The ecological momentary assessment (EMA) technique will be used via a smartphone app. Participants will be prompted to complete a self-injury and suicidality questionnaire and a mood appraisal questionnaire 3 times a day for a duration of 14 days. A wrist-worn wearable device will be used to collect heart rate, step count, and sleep patterns from participants. Dynamic structural equation modeling and machine learning approaches will be used.

RESULTS

Participant recruitment and data collection started in October 2023. Data collection and analysis are expected to be completed by December 2024. The results will be published in a peer-reviewed journal and presented at scientific conferences.

CONCLUSIONS

The insights gained from this study will not only shed light on the underlying mechanisms of NSSI but also pave the way for the development of tailored and culturally sensitive treatment options that can effectively address this major mental health concern.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/53597
Effects of oral anticoagulants on bone health (systematic literature review)
Authors: Mostbauer H.V. , Karasevska T.A. , Antonenko L.P. , Rudenko Iu.V. , Bezrodnyi A.B.
Published: October 2023

Background. Osteoporosis is actually today's problem, as it affects the quality and length of life, and increases the risk of fragility fractures, which leads to significant medical, social, and economic problems. One of the reasons for the development of secondary osteoporosis is the use of vitamin K and new oral anticoagulants, the use of which is increasing. The purpose of this review was to analyze of literature data regarding the impact of oral anticoagulants on the bone state, the risk of osteoporosis and its complications in order to improve the awareness of doctors of various specialties. Materials and methods. The lite­rature review was carried out based on the analysis of scientometric databases PubMed, Google Scholar, and Scopus using the keywords “vitamin K antagonists”; “warfarin; “osteoporosis”; “osteoporotic fracture”; “non-vitamin K antagonist oral anticoagulants”; “systematic review” for the period 2013-2023, but it did not exclude key works that were published earlier. The search was performed by two independent authors. 160 sources were selec­ted for analysis, of which 53 were used that met the search criteria. ­Results. The ana­lysis of researches showed that the effects of vitamin K antagonists and new oral anticoagulants on bone and the risk of fragility fractures are controversial. Nevertheless, the new oral anticoagulants in comparison to vitamin K antagonists seem to have a less negative effect on bone and the lowest risk of fragility fractures. The mechanism of such influence is still under examination. Conclusions. Most studies have demonstrated the adverse effects of vitamin K antagonists on bone health. A lower risk of fractures was observed with new oral anticoagulants than with vitamin K antagonists, in particular, warfarin. Taking into account the analyzed data of the literature, it is recommended to also assess the risk of fragility fractures when prescribing vitamin K antagonists or new oral anticoagulants.
Antioxidant Activity and Irritation Potency of Face Tonic Formulation from Ethanol Fraction of Sappan Wood (Caesalpinia sappan L.)
Authors: Sari Dina Yuspita , Widyasari Ratna
Published: October 2023

Sappan wood is a medicinal plant that contains phenolic compounds such as brazilin. It can be used to treat photoaging due to oxidative stress. Face tonic is one type of facial skin care cosmetic that has this purpose. The research aims to determine the formula, IC50 value, and irritation potency of face tonic from the ethanol fraction of sappan wood. The ethanol fraction of sappan wood was formulated into a face tonic preparation using glycerin and propylene glycol as cosolvents. The evaluation of face tonic involved antioxidant activity using the DPPH method. Meanwhile, the irritation-potential test was conducted using the HET-CAM method. The results showed that face tonic formulas had an antioxidant activity with IC50 values of 639.904 ppm (FI) and 620.365 ppm (FII). The irritation score of each formula was 0 (non-irritant) and 5.44 (moderate irritant). Face tonic with glycerin as a cosolvent has antioxidant activity and is safe to use.
The Potential of Tapak Dara (Catharanthus roseus) Leaves Endophytic Bacteria BETD5 as Antioxidant and Anticancer Against T47D Breast Cancer Cells
Authors: Fitri Lenni , Fauziah Fauziah , Dini Fajar , Mauludin Sinta Ayu , Dita Sasmiati Farach
Published: October 2023

This study aimed to measure antioxidant activity, to characterize biochemical properties and to measure cytotoxicity activity in BETD5 isolates. The method used in this research was experimental method. Parameters observed were antioxidant activity and cytotoxicity activity consisting of IC50 (Inhibition Concentration) and biochemical properties. Isolate used was extract of endophytic bacteria of Tapak Dara (BETD5). antioxidant activity was conducted using various sample extract concentration, namely 5ppm, 10ppm, 25ppm, 50ppm and 100ppm. The biochemical tests carried out included Triple Sugar Iron Agar (TSIA) test, Simmons Citrate (SC) test, motility test, indole test, catalase test and Methyl Red (MR) test. Cytotoxicity test on cell line T47D was performed by MTT assay using concentration (%) of 3.125; 6.25; 12.5; 25 and 50. The results showed that antioxidant activity of BETD5 was strong because IC50 value obtained was 78.485 ppm. Based on biochemical tests, BETD5 was suspected belong to the genus Staphylococcus. Cytotoxicity activity of BETD5 obtained an IC50 value of 15.58 ppm. This indicates that endophytic bacterial extract of Tapak Dara (BETD5) had moderate cytotoxicity against the T47D breast cancer cell line. GCMS test results showed that the endophytic bacterial isolate BETD5 had the highest secondary metabolite content, namely cis-Ocimene (24.31%).
Formulation and Evaluation of Topical Nano-Hydrogel of Zinc and Annona Muricata Extract
Authors: Muhtadi Muhtadi , Mugiyanto Eko , Nizmah Fajriyah Nuniek , S Slamet , Waznah Urmatul , Bagus Pambudi Dwi , Fridiana  , Safitri Eka Dian , Rosyidand Fahrun Nur
Published: October 2023

A scientific method is essential for phytochemists to deliver active ingredients in a consistent manner. This can be accomplished through the development of novel drug delivery systems for active plant compounds. The current study aims to prepare Annona muricata leaves extract (ALE) containing nano zinc formulation into a nano-particulate hydrogel. The active components were extracted by cold maceration of Anona muricata leaves in ethanol and then converted into polymeric nanoparticles by gelation method based on electrostatic interaction between the Hydroxyl Amine on Chitosan and a cluster of negative charge from the polyanion NaTPP. Zinc oxide nano particles (ZNPs) was formulated by precipitating zinc acetate with sodium hydroxide. These were then incorporated with Carbopol-940 to generate the gel matrix. The result demonstrated that polymeric nanoparticles are closely spherical in shape with a z-average 358.45 ± 11.3 nm and PDI in the range of 0.440-0.812. The gels exhibited a high viscosity, a neutral pH, and acceptable spreadability. Furthermore, a stability assay demonstrates that it has chemical stability and does not cause skin irritation, making it appropriate for transdermal delivery.
Ciplukan (Physalis Angulata Linn.) Extract Compounds Potential on High-Fat Diet Induced Nonalcoholic Fatty Liver Disease (NAFLD) for Liver Anti-Fibrotic Drug Development
Authors: Rohmawaty Enny , Dewi Sumartini , Rosdianto Aziiz Mardanarian , Usman Hermin Aminah , Zuhrotun Ade , Hendriani Rini , Wardhana Yoga Windhu , Ekawardhani Savira , Wiraswati Hesti Lina , Rahmadi Andri Reza , Agustanti Nenny , Bestari M. Begawan
Published: October 2023

An increasing percentage of people have or are at risk to develop the non-alcoholic fatty liver disease (NAFLD) worldwide. Fibrosis has also been identified as the most important predictor of prognosis in patients with NAFLD. Ciplukan (Physalis angulata Linn.)  was reported to have antifibrotic potency in CCl4-induced liver fibrotic rats. This study was conducted to evaluate the antifibrotic effect of ciplukan extract through repairing the liver function, anti-inflammatory, and lowering cholesterol. The liver fibrosis model using 20% margarine was injected subcutaneously 8 times with a frequency of twice a week for 4 weeks in 35 male and 35 female Wistar strains which were divided into 7 groups.  Furthermore, the rats were given Ciplukan extract (CPL) orally starting the 6th week of treatment with 2 different doses, namely 13.5 mg (CPL-1) and 27 mg (CPL-2) every day for 4 weeks. The histopathological changes of liver fibrosis was analyzed using Haematoxylin Eosin (HE) staining. Determination of serum IL-6 and TGF-β1 levels was carried out by the ELISA method. ALT and cholesterol levels were tested using a diagnostic kit. Single and multiple doses of ciplukan extract with or without standard therapy (Vitamin E) can reduce fibrotic scores up to 1.30±0.95 (p=0.001), TGF-β1 levels up to 24.20±2.02 ng/mL (p = 0.000), IL-6 levels up to 1.68±0.52 pg/mL (p=0.156), ALT levels up to 104.57±2.02 U/mL (p=0.001), and cholesterol levels up to 81, 07±2.02 mg/dL (p=0.000). Ciplukan herb ethanol extract was proven to have liver antifibrotic activity, which means it has potential as a liver fibrotic drug. The liver antifibrotic effect of Ciplukan herb was shown by a histopathological decrease in liver fibrosis scores accompanied by a decrease in TGF-β1, IL-6, ALT, and cholesterol levels.

Keywords: Physalis angulata Linn (Ciplukan), liver fibrosis, NAFLD, ALT, Cholesterol, IL-6
Revealing the contribution of phytochemicals in Syzygium cumini as-diabetics: A Systematic Review
Authors: Hertiani Triana , Endra Pujiastuti  , Agung Endro Nugroho  , Khoirun Nisa
Published: October 2023

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by increased blood glucose and abnormal carbohydrates, fats and proteins metabolism. Syzygium cumini (L.) Skeels (Myrtaceae) are widely used in anti-diabetic remedies and at the same time, rich in polyphenols. This study aims to provide a comprehensive review on the role of phytochemicals in Syzygium cumini to contribute in its anti-diabetic. The review covers related articles to antidiabetic AND Syzygium cumini AND phytochemicals OR bioactive which were published from 2012 to 2023. A systematic search was conducted by using databases Pubmed, Science Direct, Scopus, and Google The inclusion criteria include articles written in English as experimental research or clinical trials, randomized studies, and should contains phytochemical content profiling The exclusion criteria were other type of reports and or irrelevant to aforementioned topic. This review was written according to the reporting items guidelines for systematic payments and Meta-analysis (PRISMA), and SYRCLE's risk of bias (RoB) tool. By the systematic compensation used, 13 articles that meet the requirements were obtained and were further thoroughly reviewed. Seeds, leaves and bark of plant parts were reported to non-toxic in acute experiments on mice or rat. S. cumini contains flavonol glycosides, especially myricetin, myricitrin, quercetin, and kaempferol; phenolics, such as ellagic acid, tannins, gallic acid; alkaloids and saponins. These compounds contribution to the overall anti-diabetic activity were discussed, i.e increase of insulin sensitivity, secretion and usage of glucose in tissues; reducing insulin resistance, oxidative stress, gluconeogenesisand absorption of carbohydrates and sucrose. The seeds and leaves of S. cumini exhibit high potential to be developed as herbal products for anti-diabetics. This review finds a gap in research to support the development of the herbs as herbal products for anti-diabetics, in form of established preclinical and clinical trials and a reliable analytical methods for the phytochemical profiling.
Co-Milling: A Successful Approach to Enhance Solubility of a Poorly Soluble Antihypertensive Drug
Authors: Kamil Marwa Malik , Bayoumi Asmaa Abdelaziz
Published: October 2023

The aim of the work was to enhance the solubilization of Olmesartan-medoxomil (OM) and formulate stable, rapidly-dissolving-tablet formulations. OM, on the other hand, is classified as Biopharmaceutics Classification System (BCS) Class II drug, which indicates that it is characterized by water-insolubility. Therefore, increasing its solubilization has the potential to boost its bioavailability. For the OM evaluation, a new HPLC technique was invented and then validated in accordance with international standards. The formulation of tablets involved co-milling with certain superdisintegrants, specifically croscarmellose sodium (Ac-Di-Sol) and crospovidone in varying percentages, followed by mixing with pH-adjusting substances such as calcium carbonate to increase solubilization in cases where the drug is soluble in alkaline. Following the evaluation of the created formulations, the optimized formulations were selected for further stability assessment. Co-milling process with crospovidone greatly improved the olmesartan release. The optimized formulations were OD11 and OD12, which exhibited fast disintegration, and the release exceeded 90% within 10 min, while the release for Olmesartan medoxomil pure standard was 9.8% after 10 min. The OD11 and OD12 were chosen for further stability assessment and revealed good stability behavior, as the study on optimized formulations revealed that the degradation was less than 5% after storage for six months at 40 °C and 75% relative humidity. Some formulations exhibited good results in terms of disintegration and release. The results of the formulations (OD11 and OD12) suggested that co-grinding with crospovidone may increase the solubilization of OM to greater than 90% after 10 minutes.
Cytotoxicity Screening of Endophytic Fungi from Phaleria macrocarpa (Scheff) Boerl) Collected in Yogyakarta District
Authors: Agustina Ikra , Lay Caterina Siskadewi , Astuti Puji , Hertiani Triana
Published: October 2023

Cancer is a disease that is a global problem with a high prevalence and mortality rate. Indonesia has biodiversity with enormous potential as a source of medicinal ingredients. Phaleria macrocarpa (Scheff) Boerl) It is known to contain active metabolites, potentially an anticancer. Some endophytes are reported to be able to produce secondary metabolites similar to their parent plants. This study aimed to obtain endophytic fungi from P. macrocarpa capable of producing compounds with anticancer potential. Endophytes producing anticancer compounds were explored by screening endophytic fungi producing secondary metabolites from parts of the plant P. macrocarpa collected in the Yogyakarta area. The anticancer bioassay (MTT assay) was performed in vitro using cancer cells T47D, MCF7, HeLa, and normal Vero cells. Potential extracts were traced for their mechanism of cell cycle modulation and apoptosis using Flowcytometry. First, fungal identification was carried out on fungi producing potential cytotoxic extracts. Then the compound content was analyzed using LC-HRMS. The results from the six extracts obtained from fruit, leaf, and stem parts showed that the endophytic extract from the leaves (code PC-L2) had the best cytotoxicity compared to other endophytes and showed the best result on MCF-7 cells with an IC50 value of 110.66 µg/mL. The producing PC-L2 extract fungi are closely associated with Clonostachys wenpingii strain DUCC5606. This extract induced apoptosis but not through the mechanism of cell cycle modulation.
The Enzalutamide and EPI-001 modulate cell proliferation and metastasis markers in T47D by targeting AR/ARV7
Authors: Ali Belal M , El-Abhar Hanan S , Abdallah Dalaal M , Mohamed Ghada , Sharaky Marwa , Shouman Samia A. , Kamel Marwa
Published: October 2023

Androgen receptor (AR) and its splicing variant 7 (ARv7) play vital roles in the pathobiology of breast cancer (BC) but their role in the estrogen receptor-positive (ER+) type is controversial. Hence, we studied the influence of the blockers of AR (Enzalutamide) and ARv7 (EPI-001) on tumorigenesis processes using T47D, an ER+ BC cell line. Several techniques were employed: Sulphorhodamine assay (SRB), Flow cytometry, Immunostaining, Scratch wound healing assay, Enzyme Linked Immunosorbent assay (ELISA), and Western blot. Mechanistically, the drugs successfully arrested the cell cycle at S-phase and downregulated the protein expression of cyclins A, E, & C. Additionally, they inhibited the cell proliferation stimulator nuclear factor kappa B (NF-ĸB), whereas only EPI-001 reduced the cell regulatory marker c-Myc. They also opposed the endothelial-to-mesenchymal transition (EMT) process, by boosting the epithelial marker E-cadherin and reducing the protein expression of the mesenchymal marker fibronectin. Their anti-metastatic potential was evidenced by the hindrance of cell migration using the wound healing assay and further confirmed by the downregulation of metalloproteinase (MMP) 2 and 9 protein expression, and protein content of Rho kinase (ROCK)1 and 2. Besides, by downregulating the protein expression of vascular endothelial growth factor (VEGF) the drugs point to their anti-angiogenic aptitude. In conclusion, this in-vitro study highlights the importance of targeting AR/ARv7 using Enzalutamide and EPI-001 in decreasing proliferation cell markers, EMT, and metastasis in ER+ BC cells, findings that may have great impact in the treatment of ER+ BC.
Assessing the Antimetabolite Activity of Anthocyanins in Cantigi Fruits from Two Conservation Sites in Indonesia
Authors: Yulyana Ana , Amin Chaidir , Simanjuntak Partomuan , Abdillah Syamsudin , Rohman Abdul , Mugiyanto Eko
Published: October 2023

The objective of the current study was to evaluate the antimetabolite activity of anthocyanins in Cantigi fruits from two Indonesian conservation areas. Cantigi (Vaccinium varingiaefolium) is a native fruit species known for its rich anthocyanin content associated with various health benefits. However, more research needs to be conducted on the antimetabolite properties of these anthocyanins. This study collected Cantigi fruits from two conservation sites in Indonesia, Tangkuban Perahu (CTP) and Papandayan (CPP) Mountain, and the antimetabolite activity was evaluated using enzymatic assays. The results demonstrated significant antimetabolite activity of CTP, particularly in inhibiting α-Glucosidase (53.72±1,98 µg/ml), pancreatic lipase (110.48±2,13 µg/ml), and angiotensin-converting enzyme (27.32±1,24 µg/ml). Furthermore, our analysis using HRMS revealed the presence of three anthocyanin compounds, delphinidin, malvidin, and peonidin, which are believed to contribute to the observed antimetabolite activities of Cantigi. These findings provide valuable insights into the specific compounds responsible for the bioactivity of Cantigi and further support its potential as a natural source of bioactive substances. Future research should focus on elucidating the molecular mechanisms underlying the effects of these anthocyanins on the targeted enzymes and exploring their potential synergistic interactions.
Место встречи и пространство обмена: роль постсоветского рынка в жизни городского сообщества (на примере г. Элисты)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Lidzhieva Altana M.
Published: October 2023

Introduction. The article discusses the place, functions and significance of marketplaces in urban space. Goals. So, the paper particularly aims to consider the place, functions and significance of the marketplace in the public space of Elista. Materials. The study employs the structural-functional method and that of participant observation. Results. The Central Cossack Bazaar is an important resource for the shaping of Elista’s market economy — small and medium-sized businesses. The marketplace has changed essentially through the stages of its existence within boundaries of the urban landscape, and would prove a most suitable place for trade and supply of the population in certain historical periods. Its place in public life formed the function of a common territory and shaped the structure of traffic flows.
Floristic Studies on Karekura Village, Srirangapatna Taluk, Mandya District, Karnataka
Authors: Chandan G. R.
Published: October 2023

Abstract: A total of 133 species spanning 119 genera and 46 families have been identified in the Karekura village, Srirangapatna taluk, Mandya district, Karnataka. Dicotyledons make up 40 families, 103 genera and 108 species. There are 6 families, 14 genera and 14 species represented by monocotyledons. The Asteraceae family, which has 15 species is the most prevalent family out of the 46 families gathered.
The Effect of Collaborative Team Based AAC Intervention Using VSD on Integrated Class Participation and Communication Behavior of an Elementary School Student with Autism Spectrum Disorder
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Jimin , Kim Jusung , Lee Youngsun , Park Eunhye
Published: October 2023

Objectives This study aimed to investigate the effects of a collaborative AAC intervention using VSD on integrated class participation and communication behaviors of elementary students with autism spectrum disorder.
Methods The study participant was one elementary school student with autism spectrum disorder with complex communication needs. The tool for intervention and support plans were established through demand analysis for intervention development and diagnosis for AAC application. The independent variable was the application of cooperative VSD-based AAC intervention, and cooperative team members provided intervention at each intervention places(home, special class, integrated class).
Results Firstly, there was an increase in desirable classroom behaviors and a decrease in undesirable classroom behaviors in the inclusive classroom participation. Secondly, positive changes were observed through interviews with participating members, including the participant's enjoyment of communication, reduction in problem behaviors, increase in spontaneous participation, increase in behaviors and speech with communication intent, and increase in expressible vocabulary. Changes in the perceptions of the participant's peers and surrounding individuals in the inclusive classroom were also observed.
Conclusions This study holds significance as the first domestic research utilizing VSD in AAC intervention, enabling students to actively participate in class, supporting interactions peers without disability, facilitating communication with various individuals in diverse environments, allowing students to independently request a tablet PC or create VSD boards, and effectively linking individualized education objectives with the AAC intervention.
The serial multiple meditation of overall happiness and life satisfaction between subjective socioeconomic status and future expectation in 6th grade elementary school students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ryu Su Yeon , Pack Yun Hyun , Kim Jin Wook
Published: October 2023

Objectives The aim of this paper is to investigate the serial multiple mediation of overall happiness and life satisfaction in the relationship between subjective socioeconomic status and perception of the future in 6th grade elementary school students.
Methods This study used data from 13th (2020) Panel Study on Korean Children(PSKC) and total of 1,357 students who responded to 13th PSKC are examined by measures of subjective socioeconomic statue, future expectation, overall happiness, and life satisfaction. Path analysis is conducted to test the serial multiple meditation of overall happiness and life satisfaction.
Results Firstly, there are positive correlations among subjective socioeconomic status, future expectation, overall happiness, and life satisfaction. Second, overall happiness and life satisfaction may serially mediate the association between subjective socioeconomic status and future expectation. Last but not least, overall happiness have the greatest meditation impact between subjective socioeconomic status and future expectation while testing differences among effects of meditation.
Conclusions A student’s subjective socioeconomic status was positively associated with overall happiness, then with life satisfaction, which in turn positively contributed to future expectation. Especially, identification of and interventions for overall happiness may support a 6th grade student who think his/her socioeconomic status low to have high future expectation.
Effects of Online English Reading Aloud on Reading Accuracy and Reading Fluency in Elementary English
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Ui Jin , Kim Jeong-ryeol
Published: October 2023

Objectives The purpose of this study is to find out the effect of online English reading aloud activities on elementary English reading accuracy and English reading fluency.
Methods In this study, first, individual learning information provided by the online reading aloud program management system were analyzed. Then, based on individual data, English reading accuracy and English reading fluency scores were calculated, repeated measures ANOVA was performed on the pre, intermediate, and post scores and post-hoc tests were conducted accordingly.
Results It was confirmed that English reading accuracy and English reading fluency were improved in students who conducted online English reading aloud activities. In particular, there was a significant difference between the pre-scores and post-scores.
Conclusions There was a significant effect on improving English reading accuracy and English reading fluency by the study subjects through online English reading aloud activities. In addition, it can be expected that the longer the period and number of online English reading aloud activities, the greater the effect on English reading accuracy and English reading fluency.