bluuebunny/crossref_metadata_2025 huggingface dataset:
Some parameters of the immune system in women with hyperandrogenism
Authors: Yuldashev U. K. , Muzafarova S. A.
Published: October 2024

The article is dedicated to studying certain parameters of the immune system, which holds great significance in obstetrics and gynecology. Examining immune system parameters allows for identifying disruptions in reproductive-aged women with hyperandrogenism, which holds crucial practical implications. The authors conducted an immunological study of women with hyperandrogenism and women without this pathology. The aim of the study was to investigate the immune system status in women suffering from hyperandrogenism. Materials and methods of the study: 58 reproductive-aged women diagnosed with hyperandrogenism, under observation at the Women’s Health Center “AyolCare” in Tashkent, were examined. Comprehensive clinical and laboratory examinations were conducted for all women. The control group comprised 35 practically healthy reproductive-aged women. The obtained results indicate that women with altered hormonal balance, including those with hyperandrogenism, experience specific changes in the immune system. The conducted research revealed that the levels of T lymphocytes and T helper/inducer cells decrease, while the number of T killer cells, CD25+ cells (carrying IL-2 receptor), and CD95+ cells (carrying apoptosis signaling receptor) increases. The elevated levels of CD95+ cells indicate increased activation of apoptosis processes, which serve as a protective function of T killer cells. This increase in lymphocyte activation is likely associated with elevated levels of mature activated macrophages and a range of cytokines they produce, which directly stimulate lymphocytes. The detected imbalance in immunological parameters likely indicates that in hyperandrogenism, either the elimination of activated clones of T helper cells is absent or disrupted, which usually leads to the formation of immune response suppression. The increase in the number of activated clones of T lymphocytes is observed in the decreased process of their apoptosis, which is likely intensified by the influence of androgens.
The kisspeptin effects on the thymic regulatory cell compositions (Th17, Treg, iNKT) in vitro
Authors: Orlova E. G. , Loginova O. A. , Gorbunova O. L. , Shirshev S. V.
Published: October 2024

The peptide hormone kisspeptin, produced by neurons of the hypothalamus anterior zone, is a key regulator of the gonadostat formation and reproductive function, and has immunoregulatory activity. During pregnancy, kisspeptin is produced by the placenta, presents in the peripheral blood and affects on immune cells that express specific receptors for the hormone, including thymus cells. However, the kisspeptin effects on thymopoiesis during pregnancy have not been studied. The purpose of the work was to study the kisspeptin effect on the thymic regulatory cell composition in vitro. Thymocytes were cultured for 72 hours with kisspeptin at a concentration (9.6 pM) characterizing its maximum level in the peripheral blood during pregnancy, in the presence of CD3/CD28-activating particles and further assessed the regulatory cell composition and Ki-67 and Bcl-2 expression by flow cytometry. The percentage of T regulatory lymphocytes (Treg) was assessed as the percentage of CD4+CD25+FoxP3+ cells; T helper cells producing interleukin17 (Th17), as a percentage of CD4+IL-17A+RORγt+ cells; invariant T lymphocytes with natural killer functions(iNKT), as a percentage of CD3hiVa24Ja18+ cells in thymocyte culture. Dexamethasone (10-6M) was added to induce apoptosis. The effect of kisspeptin-primed thymic plasmacytoid dendritic cells (pDCs) on the regulatory cell composition (Th17, Treg, iNKT) in thymocyte culture was assessed. Thymic pDCs isolated by immunomagnetic separation were cultured for 24 hours with kisspeptin, and then intact autologous thymocytes were added in a ratio of 1:10 and cultured for another 72 hours. The thymocyte incubation of with kisspeptin did not affect the Tregs, iNKT and Th17 percentage in vitro, as well as the expression of Ki-67 and Bcl-2 in these cells. Under dexamethasone influence, the Bcl-2+Th17 percentage in thymocyte cultures with kisspeptin was increased. The Th17 percentage was increased in cultures of kisspeptin-primed pDCs with thymocytes, while the Treg and iNKT number did not change. It can be concluded that kisspeptin has regulatory effects on the Th17 percentage in thymocyte culture in vitro, mediating its effects by influencing thymic pDCs. And kisspeptin acted directly on thymocytes, increases the resistance of thymic Th17 to dexamethasone-induced apoptosis. The obtained results expand our understanding of the hormonal regulation of regulatory cell balance during pregnancy.
Evaluation of the preventive effectiveness of russian influenza vaccines in the epidemic seasons of 2018-2021
Authors: Erofeeva M. K. , Buzitskaya Zh. V. , Shakhlanskaya E. V. , Pisareva M. M. , Stukova M. A. , Lioznov D A.
Published: October 2024

Monitoring the effectiveness of influenza vaccines annually enables the development of measures aimed at decreasing influenza incidence, hospitalization, and mortality rates. The epidemiological effectiveness of several Russian domestic influenza vaccines was evaluated in St. Petersburg in the 2018-2021 epidemic seasons. Male and female participants (N = 6912) aged 18-23 were monitored from 2018 to 2021. Sovigripp, Grippol Plus, Ultrix, and Ultrix Quadri inactivated influenza vaccines were used for immunization. In 2018-2019, when the vaccine strains fully matched the circulating influenza viruses, prophylactic vaccination resulted in a 2.7 to 7.1-fold reduction in influenza cases. The protective effectiveness of the vaccines against influenza and acute respiratory infections (ARIs) totalled 52.4%, reaching 73.0% effectiveness against influenza after laboratory confirmation. In the epidemic season 2019-2020, when the circulating viruses and vaccine strains did not fully match, the incidence of influenza and ARIs reduced twice due to vaccination; the total vaccine effectiveness against influenza and ARIs amounted to 50.0%. The Grippol Plus, Ultrix, and Ultrix Quadri vaccines proved to be the most effective, demonstrating a total effectiveness of 70.6%-75.0% and a 65.5%-83.5% effectiveness against influenza A and B. In the 2020-2021 epidemic season, no data on the preventive effectiveness of the influenza vaccines could be obtained due to the outbreak of COVID-19 and the absence of detectable influenza virus shedding in the study participants. The results obtained are consistent with WHO experts’ estimates which indicate that modern influenza vaccines reduce the incidence of influenza in adults by 70-90% if the vaccine strains match the circulating virus strains.
Indicators of the cytokine profile and standard immunogram in the controlled and uncontrolled course of bronchial asthma in children
Authors: Suprun E. N. , Suprun S. V. , Kozlov V. K. , Galyant O. I. , Evseeva G. P.
Published: October 2024

Bronchial asthma in children is a multifactorial disease, but it is based on atopic inflammation, which is the focus of the main methods of research and therapy of this pathology. However, if we evaluate not only the fact of the appearance of bronchial asthma in a particular patient, but also consider its course in more detail, and especially the possibility of achieving control over the disease, then indicators of not only atopic inflammation, but also local inflammation in general, acquire great influence, which is one of the reasons for the continuing high percentage of uncontrolled and partially controlled course bronchial asthma in children.
The purpose of this work is to identify changes in cytokine status indicators and immunograms – markers of the risk of uncontrolled bronchial asthma.
167 patients with bronchial asthma were examined, who, based on a standard clinical and instrumental examination, according to the criteria of clinical recommendations, were divided into two groups – controlled (70 people) and partially controlled and uncontrolled (97 children). All of them had their cytokines and IgA, IgM, IgG, IgE levels determined, in blood serum by ELISA, subpopulations of lymphocytes by flow cytometry, indicators of neutrophilic phagocytosis by light microscopy.
In the group with uncontrolled asthma, the following significant differences were noted: a decrease in the level of IL-7, IL-9 and an increase in IL-8, there is also a higher level of B lymphocytes, IgE and IgM, and a lower level of IgA, similar changes, but less pronounced, were previously detected in other studies when comparing patients with bronchial asthma and conditionally healthy, as well as mild and severe course diseases. There were no significant differences in the other studied indicators.
It is noteworthy that the greater influence on the control of the disease in bronchial asthma is not exerted by atopic cytokines responsible for the very fact of atopic inflammation, but by cytokines of general inflammation, such as IL-7, IL-8, IL-9, regulating the severity of inflammation in general, the role of IL-8 as a cytokine of granulocyte chemotaxis regulating local inflammation is especially interesting.
New concept for the prevention of acute respiratory infections
Authors: Borisov A. G. , Tikhonova E P. , Kostromina R. A. , Anisimova E. N. , Sadowsky I. S. , Bronnikova E. P. , Peretyatko O. V. , Savchenko A. A.
Published: October 2024

Medical personnel and family members of patients with acute respiratory diseases (ARD) are at increased risk of infection during epidemics or pandemics. In this regard, it is necessary to develop and implement accessible preventive measures. The aim of the study was to evaluate the effectiveness of the use of IFNα-2b for the prevention of acute respiratory viral infections in persons located at the source of infection (medical personnel and members of their families).
Patients (n = 31) with acute respiratory infections and 117 people from their environment (family members in constant contact with patients) were examined. The subjects underwent a clinical examination and laboratory tests a clinical blood test and a study of the content of the main populations and subpopulations of lymphocytes in the blood. Persons in contact with ARD patients were divided into three groups: persons who received the drug “Grippferon” for 7 days; persons who received the drug “Grippferon” in a prophylactic dose for 7 days; persons in contact with patients with ARD but who have not received the drug “Grippferon”.
When assessing the state of the immune system, it was found that the most common type of immune reaction in patients and their people around was activation of innate immunity (48.39% and 66.67%, respectively). At the same time, immunodeficiency in the group of patients with ARD was detected much more often than in persons in contact with them. In addition, patients were more likely to have monocytosis (1.4 times), T lymphocytopenia (2.1 times) and an increase in the number of regulatory T lymphocytes (7.6 times). More than 50% of those examined in both groups showed an increase in the number of NK cells in the blood. An examination of persons in contact with patients with ARD after 7 days of using the “Grippferon” in different doses revealed that the lowest frequency of acute respiratory viral infections symptoms was found in the group receiving IFN at a therapeutic dose. In the group receiving IFN in a prophylactic dose, the frequency of acute respiratory viral infection (ARVI) symptoms was detected in almost 40% of those examined. More than 80% of people from the group who did not receive the “Grippferon” had symptoms of ARVI after a week of contact with patients with ARD.
Thus, the use of IFN in therapeutic doses during the epidemic for persons in contact with patients is proposed as a new concept for the prevention of ARD.
Efficacy and pharmacodynamics of herbal medicine in patients with metabolic phenotype of osteoarthritis
Authors: Shirinsky I. V. , Filatova K. Yu. , Shirinsky V. S.
Published: October 2024

High prevalence of the metabolic phenotype of osteoarthritis (MPOA) and unsatisfactory methods of its treatment necessitate the development of novel therapeutic approaches for this phenotype of OA. Turmeric preparations have a wide range of biological activity; their use in patients with MPOA can be effective and reduce the drug burden. In the present paper, we review our own published research findings on the effectiveness and pharmacodynamics of turmeric preparations in patients with MPOA. In the two studies, we evaluated the effects of two curcumin-containing parapharmaceuticals: Epigenorm Antivir (EA) and Curcumin. Forty-one women with MFOA were included in both studies. Twenty-three patients received EA at a daily dose of 1000 mg for 12 weeks, and 18 patients received curcumin from Evalar at a dose of 1000 mg for 8 weeks. The endpoints for both studies were VAS pain, dysfunction and other symptoms of OA measured using the KOOS scale. After 12 weeks of EA treatment, there was a 2.5-fold decrease pain levels. The decrease in pain was associated with an improvement in the patient’s daily and sports activities and quality of life. These effect sizes were classified as moderate to large according to Cohen. No adverse events were observed during the period of taking EA. Clinical improvement was associated with a decrease in the content of MS individual components: low-density lipoprotein cholesterol and triglycerides. The treatment caused a decrease in the level of systemic inflammation, as evidenced by a decrease in the concentration of TNFα, histamine, IL-18, C-reactive protein, and neopterin. The concentrations of IL-10 and adiponectin increased after treatment. In another study, treatment with curcumin for 4 weeks had an analgesic effect, improved measures of function and quality of life. Clinical improvement was associated with the reductions in serum levels of a number of proinflammatory cytokines, C-reactive protein, and lipids. Thus, the results of the pilot studies evaluating efficacy, safety, and pharmacodynamics of parapharmaceuticals EA and Curcumin in patients with MFOA indicate pleiotropic effects of the interventions. The findings provide a rationale for conducting larger, controlled, blind, randomized clinical trials.
Hindistan'daki Turistik Şehirlerin İklim Değişkenlerinin Tahminine Yönelik Hibrit ConvGRU Modeli
Authors: Utku Anıl
Published: October 2024

Hava durumu tahmini tarım, sağlık, ulaşım, turizm, hava kalitesi ve endüstriyel üretim gibi alanlarda etkinliğin ve verimliliğin sağlanabilmesi açısından oldukça önemlidir. Geleneksel hava durumu tahmin modelleri uzun vadeli tahminlerde yetersiz kalmaktadır. Yapay zekâ yöntemleri, sıcaklık, nem, rüzgâr hızı ve hava basıncını gibi hava durumu verileri arasındaki karmaşık ilişkileri öğrenerek geleceğe dönük başarılı tahminler üretebilmektedir. Bu çalışmada, Hindistan'ın önemli turizm şehirlerinden olan Agra, Jaipur, Jodhpur, New Delhi ve Rishikesh'in sıcaklık, nem ve çiğ noktası gibi uzun vadeli iklim değişkenlerinin tahmin edilmesi amaçlanmıştır. Bu amaçla, geliştirilen ConvGRU hibrit modeli, RF, SVM, CNN, LSTM ve GRU modelleriyle kapsamlı bir şekilde karşılaştırılmıştır. 2010-2024 yılları arasına ait gerçek zamanlı ve güncel bir veriseti kullanılmıştır. Deneysel sonuçlar, ConvGRU’nun tüm şehirler ve iklim değişkenleri için 0,9’un üzerinde R2 değeriyle karşılaştırılan modellerden daha başarılı olduğunu göstermiştir.
Advancing Computational Fluid Dynamics through Machine Learning: A Review of Data-Driven Innovations and Applications
Authors: Rahman Md. Saifur , Hazra Shrabanti , Chowdhury Imtiaze Ahmed
Published: October 2024

This review explores Machine Learning (ML) integration with Computational Fluid Dynamics (CFD) to enhance simulation accuracy and efficiency. CFD has long been the standard for fluid flow analysis, but its computational cost and limitations in handling complex flows have spurred interest in data-driven approaches. With its ability to model nonlinear relationships, machine learning offers a promising solution. The review covers vital methodologies, including data acquisition from CFD simulations, feature extraction, and the selection of ML models such as neural networks and supervised learning algorithms. Furthermore, it examines the application of ML in accelerating CFD simulations and improving turbulence modeling. While promising, challenges remain, particularly in ensuring ML models respect the underlying physical laws governing fluid dynamics. The review concludes by discussing future research directions, particularly in physics-informed machine learning, which seeks to integrate physical constraints into the ML process. This combination of data-driven and physics-based approaches can transform CFD applications across industries.
Los planes de ordenación del territorio en Andalucía: el POTA. Los planes de ordenación del territorio de ámbito subregional. El plan de protección del corredor litoral
Authors: Chamizo Calvo Luisa Teresa
Published: October 2024

SUMARIO: II.1. EL PLAN DE ORDENACIÓN DEL TERRITORIO DE ANDALUCÍA II.1.1. Procedimiento de elaboración y aprobación II.1.2. Estructura del documento II.1.3. El Modelo Territorial de Andalucía II.1.4. Las Estrategias de Desarrollo Territorial II.1.5. Zonificación II.1.6. El Desarrollo del POTA II.1.7. Sentencias sobre el POTA II.2. LOS PLANES DE ORDENACIÓN DEL TERRITORIO DE ÁMBITO SUBREGIONAL II.2.1. Ámbitos ordenados por planes de ordenación del territorio de ámbito subregional II.2.2. Determinaciones de los planes de ordenación del territorio de ámbito subregional (POTAS) II.2.3. Los planes de ordenación del territorio de ámbito subregional y el planeamiento urbanístico municipal II.2.4. Jurisprudencia sobre los Planes de Ordenación del Territorio de ámbito Subregional II.3. EL PLAN DE PROTECCIÓN DEL CORREDOR LITORAL II.3.1. La Génesis del Plan II.3.2. La elaboración del PPCLA II.3.3. Documentación del PPCLA II.3.4. Determinaciones del PPCLA II.4. CONCLUSIONES
LA EJECUCIÓN URBANÍSTICA.- Introducción: Reflexiones previas. Ejecuciónsistemática y ejecución asistemática. Ideas generales. Presupuestos legales para la actividad de ejecución. Instrumentos de gestión y proyectos de urbanización. La figura del Agente Urbanizador en Andalucía. Los tres tradicionales sistemas de actuación en la normativa urbanística: Compensación, cooperación y expropiación.
Authors: Compagni Mamen , Gil Bermejo Ignacio
Published: October 2024

SUMARIO: I. INTRODUCCIÓN: REFLEXIONES PREVIAS I.1. La trascendencia de la actividad de la gestión y ejecución urbanísticas I.2. Distribución de competencias en la fase de ejecución del planeamiento II. PRESUPUESTOS LEGALES PARA LA ACTIVIDAD DE EJECUCIÓN II.1. Órganos encargados de dirigir y ejecutar el planeamiento urbanístico II.2. Contenido de la actividad de ejecución de planeamiento II.3. Programación y plazos II.4. Ejercicio de la disciplina urbanística en la fase de gestión y ejecución urbanísticas II.5. Requisitos mínimos exigidos para la ejecución del planeamiento III. INSTRUMENTOS DE GESTIÓN Y PROYECTOS DE URBANIZACIÓN III.1. Los Proyectos de Urbanización III.2. La Reparcelación IV. CONVENIOS URBANÍSTICOS DE GESTIÓN V. LA FIGURA DEL AGENTE URBANIZADOR EN ANDALUCÍA VI. EJECUCIÓN SISTEMÁTICA Y EJECUCIÓN ASISTEMÁTICA. IDEAS GENERALES VI.1. La ejecución sistemática: la actuación mediante unidades de ejecución VI.2. La ejecución asistemática VII. LOS TRES TRADICIONALES SISTEMAS DE ACTUACIÓN EN LA NORMATIVA URBANÍSTICA: COMPENSACIÓN, COOPERACIÓN Y EXPROPIACIÓN VII.1. El sistema de compensación VII.2. El sistema de cooperación VII.3. El sistema de expropiación VIII. LA TRASCENDENCIA DE LA EJECUCIÓN URBANÍSTICA EN LA RECONDUCCIÓN A LA LEGALIDAD DE ACTUACIONES ILEGALES EN SUELO NO URBANIZABLE IX. CONCLUSIONES
Disciplina Urbanística represiva. La incoación, tramitación y resolución de los expedientes de restablecimiento de la legalidad urbanística y sancionador. Obras legalizables y no legalizables. Suspensión y reanudación del expediente sancionador ante la constancia de actuaciones penales por los mismos hechos.
Authors: Moreno Pérez de la Cruz Manuel Evaristo
Published: October 2024

SUMARIO: V.1 DISCIPLINA URBANÍSTICA REPRESIVA V.2 LA INCOACIÓN, TRAMITACIÓN Y RESOLUCIÓN DE LOS EXPEDIENTES DE RESTABLECIMIENTO DE LA LEGALIDAD URBANÍSTICA Y SANCIONADOR V.3 MEDIDA CAUTELAR DE SUSPENSIÓN V.4 RESTABLECIMIENTO DE LA LEGALIDAD URBANÍSTICA V.5 PROCEDIMIENTO SANCIONADOR V.6 OBRAS LEGALIZABLES Y NO LEGALIZABLES V.6.1 Obras legalizables V.6.2 Obras no legalizables V.7 CUMPLIMIENTO POR EQUIVALENCIA V.8 OBRAS MANIFIESTAMENTE INCOMPATIBLES CON LA ORDENACIÓN URBANÍSTICA V.9 DECLARACIÓN EN SITUACIÓN DE ASIMILACIÓN A LA DE FUERA DE ORDENACIÓN V.10 SUSPENSIÓN Y REANUDACIÓN DEL EXPEDIENTE SANCIONADOR ANTE LA CONSTANCIA DE ACTUACIONES PENALES POR LOS MISMOS HECHOS  CONCLUSIONES
Conclusiones Finales
Authors: Gamero Ruiz Eva
Published: October 2024

Conclusiones finales de la obra
Báo cáo trường hợp vỡ lách tự phát do huyết khối sau sinh trên sản phụ tiền sản giật nặng có biến chứng HELLP
Authors: Nguyễn Thị Thu Phương , Nguyễn Phương Tú , Nguyễn Phương Nam
Published: October 2024

Đặt vấn đề: Huyết khối tĩnh mạch là một tình trạng y tế nghiêm trọng có thể dẫn tới nhiều biến chứng chảy máu trong thời gian mang thai, nghiêm trọng hơn là có khả năng gây tử vong cả mẹ và thai. Hội chứng HELLP là một biến chứng hiếm gặp (0,5 - 0,9% tổng số thai kỳ), trong đó có tỷ lệ rất hiếm xuất hiện kèm theo khối máu tụ ở gan hoặc lách (chiếm 2% trong số trường hợp HELLP). Tuy nhiên những khối máu tụ này có thể đe doạ ngay lập tức tới tính mạng của thai phụ trong trường gây căng giãn tạng quá mức dẫn tới vỡ tạng. Việc phát hiện chính xác và xử trí kịp thời sẽ giúp bảo vệ an toàn tính mạng cho sản phụ.
Ca lâm sàng: Sản phụ thai 35 tuần 5 ngày nhập viện trong tình trạng tiền sản giật nặng có biến chứng HELLP được mổ lấy thai và sau mổ phát hiện huyết khối tĩnh mạch nhiều lách kèm theo tình trạng chảy máu trong ổ bụng. Trong quá trình đánh giá nguyên nhân chảy máu, chúng tôi phát hiện đường vỡ lách 2cm và đã phẫu thuật cắt lách. Quá trình hậu phẫu của bệnh nhân ổn định và ra viện sau 1 tuần.
Kết luận: Hội chứng HELLP là biến chứng nặng của thai kỳ và có thể gây ra nhiều biến chứng khác. Phát hiện các biến chứng đi kèm hội chứng HELLP giúp đưa ra thái độ xử trí kịp thời, tránh ảnh hưởng nặng nề tới bệnh nhân.
Nhân trường hợp viêm não tự miễn kháng thụ thể NMDA có liên quan đến u quái buồng trứng
Authors: Nguyễn Thị Thu Phương , Nguyễn Phương Tú , Nguyễn Phương Nam
Published: October 2024

Viêm não tự miễn là một nhóm các bất thường đặc trưng bởi các triệu chứng rối loạn chức năng hệ viền và ngoài hệ viền xảy ra liên quan đến các kháng thể chống lại các kháng nguyên nội bào, synap hoặc các protein khu trú trên bề mặt tế bào thần kinh. Các triệu chứng lâm sàng đặc hiệu ghi nhận gồm rối loạn tâm thần (lo lắng, kích động, hành vi kỳ quái, ảo giác, hoang tưởng và suy giảm trí nhớ); co giật, trạng thái động kinh và các triệu chứng thần kinh khác (loạn trương lực cơ, rối loạn vận động mắt,…) và rối loạn thông khí trung tâm. Chẩn đoán tình trạng này dễ nhầm lẫn với các triệu chứng của bệnh lý tâm thần vận động dẫn đến chậm trễ trong việc điều trị. Chẩn đoán sớm và điều trị kịp thời bệnh viêm não thụ thể kháng NMDA, đặc biệt ở phụ nữ trẻ có u quái buồng trứng, đã cải thiện đáng kể cơ hội phục hồi sức khỏe hoàn toàn và cải thiện tiên lượng về sức khỏe sinh sản của người bệnh.
Nhân một trường hợp u lympho ác tính tại cơ tử cung: Tổng quan và ca bệnh
Authors: Nguyễn Quốc Tuấn , Nguyễn Khánh Dương , Nguyễn Phương Tú , Nguyễn Hải Phương , Cao Văn Hùng
Published: October 2024

Trong cơ thể có hai hệ thống gen duy trì và kiểm soát sự phát triển bình thường của tế bào, khi một trong hai hệ thống có mất cân bằng thì ngay lập tức sẽ xuất hiện những bất thường ở tế bào, việc biến đổi các cấu trúc di truyền của tế bào sẽ dẫn tới hoạt hoá các gen tiền ung thư hoặc bất hoạt các gen chống ung thư dẫn tới tình trạng tăng sinh không kiểm soát được của tế bào, tế bào lympho cũng vậy cho nên có thể gây ra các khối u lympho có tính chất ác tính và có thể xuất hiện ngoài hạch. U lympho ác tính tại tử cung là trường hợp rất hiếm và trên lâm sàng thường không có triệu chứng đặc hiệu, các tiêu chuẩn chẩn đoán chủ yếu dựa vào mô bệnh, hoá mô nên thường chỉ được chẩn đoán xác định sau khi đã phẫu thuật loại bỏ. Việc phối hợp điều trị và theo dõi sau đó còn gặp nhiều khó khăn do chưa có một hướng dẫn y khoa cụ thể, trường hợp ca bệnh hiếm dưới đây hy vọng góp một chút thông tin vào các dấu hiệu nhận biết và chẩn đoán trên lâm sàng và cận lâm sàng.
U nguyên bào nuôi tái phát nguy cơ cực cao sau điều trị 7 năm: báo cáo 1 trường hợp và tổng quan y văn
Authors: Đào Minh Hưng , Nguyễn Văn Thắng , Nguyễn Thái Giang , Phạm Trí Hiếu
Published: October 2024

U nguyên bào nuôi là nhóm bệnh lý tân sản ác tính hoặc có tiềm năng ác tính của nguyên bào nuôi. Hầu hết bệnh nhân UNBN tái phát trong năm đầu tiên, các trường hợp tái phát sau 5 năm là hiếm gặp. U nguyên bào nuôi tái phát có tiên lượng xấu do rất khó điều trị, tỷ lệ tái phát cao và tỷ lệ sống sau 5 năm thấp. Hóa trị với phác đồ đa hóa chất như EMACO (Etoposide, Methotrexate, Actinomycin D, Cyclophosphamide và Vincristine) là biện pháp quan trọng nhất để tăng tỷ lệ thoái lui bệnh và giảm tỷ lệ tái phát của bệnh nhân UNBN đã tái phát. Phác đồ bắt đầu với hóa chất EP (etoposide, cisplatin) liều thấp, đang được áp dụng tại nhiều trung tâm hiện nay, nhằm hạ thấp tỷ lệ tử vong do vỡ các nhân di căn của bệnh nhân UNBN nguy cơ cực cao nếu như bệnh nhân điều trị với phác đồ đa hóa chất tiêu chuẩn như EMACO từ ban đầu. Chúng tôi báo cáo 1 trường hợp U nguyên bào nuôi tái phát nguy cơ cực cao xuất hiện 7 năm sau điều trị: bệnh nhân vào viện xét nghiệm βhCG huyết thanh tăng rất cao với tổn thương di căn gan, phổi kích thước lớn. Chúng tôi trình bày ngắn gọn tổng quan y văn.
Mô tả một số yếu tố liên quan đến tâm lý phụ nữ sau sinh hai con cùng là gái
Authors: Đào Thị Thanh Hường , Đỗ Thanh Huyền , Nguyễn Thị Thu Ngân
Published: October 2024

Mục tiêu nghiên cứu: Đánh giá tâm lý của người phụ nữ khi sinh con thứ 2 cùng giới là nữ và các yếu tố liên quan.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang được tiến hành trên 200 sản phụ sau mổ lấy thai và đẻ thường tại Bệnh viện Phụ sản Trung ương có con thứ 2 cùng giới là nữ từ tháng 1/2024 đến tháng 6/2024.
Kết quả: Tần suất mắc các lo âu, rối loạn trầm cảm, căng thẳng lần lượt là: 42,0%; 12,0% và 8,0%. Mức độ các rối loạn phần lớn từ nhẹ và vừa với điểm trung bình tương ứng là 2,99 ± 4,10; 6,78 ± 5,96 và 5,67 ± 6,83. Việc mong muốn sinh được con trai ở nhóm sống chung với gia đình (36,61%) khác biệt nhóm không sống chung với gia đình (63,39%) là có ý nghĩa thống kê (p = 0,01).
Kết luận: Tình trạng tâm lý bất ổn trước và sau sinh có liên quan. Mong muốn sinh được con trai có liên quan với việc sống chung cùng gia đình. Nguy cơ bị trầm cảm của những phụ nữ sống chung với bố mẹ chồng sẽ cao hơn so với không sống chung với bố mẹ chồng.
Conflictos de género en un equipo de investigación de una Universidad Nacional de Argentina: una interpretación desde la sociobiología
Authors: Abril Adriana
Published: October 2024

Desde sus orígenes el Homo sapiens vive en sociedades lideradas por un hombre (macho α). Sin embargo, en la actualidad es cada vez mas frecuente que los hombres integren equipos de trabajo con igual o menor jerarquía que las mujeres. Por lo que muchos de los conflictos laborales que se presenta en estos casos podrían deberse a la dicotomía entre el patrón de comportamiento genético-cultural del hombre y el rol que desempeña en el grupo. Este trabajo presenta una interpretación desde la sociobiología de hechos que generaron conflicto laboral durante más de 25 años en un equipo de investigación de la Universidad Nacional de Córdoba, compuesto casi equitativamente por personas de ambos géneros y liderado por una mujer. Se analizaron las reacciones masculinas según las expresiones características de los machos α y se agruparon los casos según las actividades que reflejan eficiencia y éxito profesional. Los resultados demuestran que la mayoría de las reacciones masculinas responden claramente al patrón de comportamiento de macho α. Se espera que este análisis brinde nuevos elementos de juicio para una mejor interpretación de los conflictos de género y de esa manera contribuir a la búsqueda de soluciones para este grave problema.
Fostering Multicultural Community Harmony to Enhance Peace and Sustainable Development Goals (SDG’s)
Authors: Muthoifin  , Abuzar Muhammad , Mahmudulhassan  , Afiyah Ishmah , Nirwana Andri , Nuha  , Setianto Gigih , Waston
Published: October 2024

Purpose: This service aims to foster harmony in a multicultural community in the city of Solo as a concrete step to increase peace and support the achievement of the Sustainable Development Goals (SDGs).   Theoretical Framework: This study uses a cultural integration thinking framework and a participatory approach to building social harmony. The focus is on developing an understanding and appreciation of cultural diversity, as well as increasing positive interactions between ethnicities and religions to create an inclusive environment.   Methods: This service uses a participatory approach involving a variety of local stakeholders, including ethnic and religious communities, local governments, and community institutions. Activities include organizing intercultural dialogue workshops, cultural diversity training, and public campaigns to promote tolerance and peace.   Results and Conclusion: The results of this service show an increased awareness of cultural diversity and appreciation for differences among the people of Solo. Inter-ethnic and religious interactions are increasing, creating a stronger foundation for social harmony. In conclusion, participatory and integrative approaches are effective in building harmony in multicultural societies to support peace and sustainable development.   Implications: This service has a positive impact by increasing tolerance, reducing social conflicts, and strengthening social cohesion in the city of Solo. The impact is also seen in increasing community participation in local development activities and achieving related SDGs targets.   Originality/value: Its uniqueness lies in its participatory approach that actively involves all relevant parties, as well as focusing on cultural integration as the main foundation for the development of sustainable social harmony in a multicultural environment such as the city of Solo.
Advancements in Digital Forensics: A Quantitative Analysis of Cell Tower Triangulation Techniques
Authors:   Research Scholar, Doctorate Program in Management Studies, The Indian Institute of Business Management and Studies, Mumbai, India., Bansal Siddharth Kumar
Published: October 2024

This study delves into the accuracy and reliability of Cell Tower Triangulation (CTT) in digital forensics, employing a diverse sample of mobile devices across various real-world scenarios—criminal investigations, missing persons, and corporate security breaches. By simulating these situations, the research aims to provide a comprehensive understanding of CTT’s effectiveness in urban and rural settings. Data was meticulously collected on signal strength, tower locations, and timestamps, and analyzed using statistical methods to assess CTT accuracy and reliability. Findings from descriptive statistics, comparative analyses, precision metrics, and correlation analyses reveal significant insights into CTT’s application in digital forensics. Despite certain limitations in precision, indicated by the variability in virtual triangle sizes, the study underscores the potential of CTT in supporting investigations while also highlighting the importance of ethical considerations and legal compliance. This research contributes to the advancement of digital forensics, offering a nuanced understanding of CTT’s capabilities and limitations.
Inhibition of Citronella Essential Oil (Cymbopogon Nardus) Bengkulu on Bacterial Growth after Endodontic Treatment
Authors:   Dental Conservation Dept, Faculty of Dentistry, Prof. Dr. Moestopo (B) University, Jakarta, Indonesia, Permatasari Rina , Sharmauly Fernanda ,   Faculty of Dentistry, Prof. Dr. Moestopo (B) University, Jakarta, Indonesia, Achriana Safira ,   Faculty of Dentistry, Prof. Dr. Moestopo (B) University, Jakarta, Indonesia
Published: October 2024

Background: Root canal treatment aims to address pulpal infection and prevent reinfection, which is often caused by bacteria such as Enterococcus faecalis and Staphylococcus aureus. Citronella essential oil (Cymbopogon nardus) from Bengkulu, containing antibacterial compounds, has potential to inhibit the growth of these bacteria. Objective: This study evaluated the effectiveness of citronella essential oil against E. faecalis and S. aureus. Materials and Methods: The method used was the disc diffusion technique with 20 samples each of E. faecalis and S. aureus in BHI media. Citronella essential oil was tested at concentrations of 50%, 75%, and 100%, with 2% CHX as the positive control. The inhibition zones were measured after 24 hours. Results: The highest inhibition for E. faecalis was found at 100% concentration (2.56 mm), while for S. aureus, it was at 50% concentration (1.67 mm). Significant differences (p<0.05) were observed at all concentrations of citronella essential oil for both bacteria. Conclusion: Citronella essential oil from Bengkulu exhibited weak antibacterial activity against E. faecalis and S. aureus. Its potential as an alternative for root canal treatment requires further development.
Pesquisa, desenvolvimento e inovação e o desenvolvimento sustentável: o caso da Universidade do Estado do Amazonas
Authors:   , Lobo Felipe de Oliveira
Published: October 2024

Este trabalho buscou contribuir nas discussões sobre o desenvolvimento brasileiro diante das interações entre universidades e empresas, que intensificam a complexidade de produtos e processos industriais a partir do conhecimento científico e tecnológico produzidos nas primeiras. Para tanto, e considerando o imperativo da sustentabilidade ambiental, o objetivo foi analisar os impactos dos recursos de pesquisa, desenvolvimento e inovação (PD&I) em projetos que possam influenciar o desenvolvimento sustentável. O foco empírico da análise são os projetos desenvolvidos pela Universidade do Estado do Amazonas (UEA), com base no quadro normativo que incentiva essas interações no estado, contribuindo para enfrentar os desafios impostos pelo trade-off entre crescimento econômico e desenvolvimento sustentável Diante das expectativas geradas pela interação entre as organizações mencionadas e a singularidade da região, questiona-se a aderência e a contribuição dos projetos de PD&I desenvolvidos pela UEA, com os incentivos dados pela Lei nº 8.387/1991 e suas alterações, para o desenvolvimento sustentável da região, à luz do quadro teórico do Triple Bottom Line. Foram analisados os projetos e ações segundo as variáveis da dimensão econômica, ambiental e social, considerando a necessidade de implementar e avaliar medidas que visem a diminuição dos impactos causados pelos problemas ambientais e sociais. Como conclusão, foi identificado que muitos dos projetos analisados apresentam baixa aderência à dimensão ambiental, com uma priorização evidente da dimensão econômica, apontando para a necessidade de maior equilíbrio entre essas dimensões para se alcançar um desenvolvimento verdadeiramente sustentável na região. Palavras-Chave: Desenvolvimento sustentável; PD&I; Zona Franca de Manaus.
AI-Driven Anomaly Detection: A New Frontier in Web Application Security
Authors:   USA, Thopalle Praveen Kumar
Published: October 2024

In an era where cyber threats are not just evolving but escalating at an alarming rate, traditional cybersecurity measures are proving inadequate to safeguard sensitive digital assets. This research confronts the pressing need for a radical transformation in cybersecurity practices through the aggressive integration of Artificial Intelligence (AI) models. By harnessing the power of AI, we aim to redefine the landscape of cybersecurity, enabling organizations to preemptively identify, analyze, and neutralize threats before they manifest into catastrophic breaches. This study meticulously examines the integration of AI across key cybersecurity domains: threat modeling, real-time threat analysis, automated backup management, disaster recovery strategies, and rigorous source code review. As cybercriminals employ increasingly sophisticated tactics to exploit vulnerabilities, it becomes imperative for organizations to adopt a proactive stance powered by AI-driven automation and intelligent analytics. We delve into the fundamental reasons behind the urgent necessity for AI in cybersecurity, spotlighting the escalating complexity of cyberattacks and the inadequacy of conventional defenses. Current practices are critically analyzed to expose gaps and highlight the dire need for robust solutions that can adapt and evolve. The research provides a blueprint for leveraging cutting-edge AI technologies to transform threat identification and mitigation processes, fostering a security culture that is anticipatory rather than reactive.
Personality, Trust and Attachment among Young Adults
Authors: Aleena Shijo  , Gayathri Devi J S
Published: October 2024

Young adulthood is a stage of life characterized by significant personal growth and professional development. Personality is the dynamic organization within the individual of those psychophysical systems that determine his characteristics behaviour and thought, personality dimensions are extroversion, agreeableness, conscientiousness, neuroticism and openness to experience. Trust is the state involving confident positive expectations about another's motives regarding oneself in situations of risk. Attachment is the deep emotional connection between two people, the dimensions of attachment are close, depend and anxiety. The objectives of the study were to examine the connection between personality, trust and attachment among young adults. 200 young adults of age 18-25 made up the sample, which included both males and females. Short version of the Big Five Inventory (BFI‐10), Trust in Close Relationships Scale and Revised Adult Attachment Scale (RAAS) were the instruments employed. The data was examined using the Spearman's correlation test. According to the study, there is no significant correlation between personality dimensions and trust in romantic relationship. And there exists a positive correlation between personality factor extroversion and attachment subscale close and there exist a negative correlation between personality factor neuroticism and attachment subscale close. And there exist a positive correlation between personality factors extroversion and agreeableness with attachment subscale depend, also there exist a negative correlation between personality factor neuroticism and attachment subscale depend. And also there exist a positive correlation between the personality factor depend and trust.
Review on Efficacy of Phytogenic Galacto Powder Supplement as Potential Galactogague
Authors: Dr. Sujani Gudipati
Published: October 2024

Milk production, in cattle as the name suggests is not just a monomer but a conglomeration of lactation issues faced by the industry like post-partum changes, endometritis, milk fever, acetonemia, oedema, galactic and may more. Synthetic substances named Galactogogues were used to combat this situation, but over a period of time and long applications lead to the reduction in the livability and disease tolerance of the animal, not to say a profound decrease in milk production. The herbal alternatives, the phytogenic Galacto herbs, involving the age old traditional Trigonella, Asparagus, Silybum etc when given as a synergestic blend acted as the Phytogenic Galactogoguesdue to their phytochemicals. The earlier studies on the individual Galacto herbs prove their efficacy, this review is about their blended work in various aspects of lactation and the expected results. This review finds a relevance to signify the importance of the synergestic blend of Galacto powder from the herbs presenting enhanced lactation, prevention and correction of lactational issues, an innovative area for more futuristic research too.
Assessments ofConflicts Over Natural Resource Use and Their Handling in Babile Elephant Sanctuary, Eastern Ethiopia
Authors: Demeke Shimelis Tekletsadik , Geleta Taye Lemma
Published: October 2024

The focus of this study aims to assess the conflicts over natural resource uses and its management in Babile Elephant Sanctuary, Eastern Ethiopia. A simple random sampling method was used to gather data from sampled households. A total of 152 households were selected from three Peasant Associations (Erer Ebada, Agdora, and Dendema) of three districts (Babile, Fedis, and Babile Dendema) due to their proximity and the intensity of resource utilization in the sanctuary. A questionnaire survey, key informant interview, focus group discussion, field observation, and secondary data sources were usedto generate the required data. Both qualitative and quantitative analysis approaches were employed to analyze the data. The result showed that, except for wildlife risk on humans and public participation in the sanctuary's management, all other factors were statistically significant at (P<0.050). From the overall respondents, about 44.1%, 42.1%, and 40.1% of the respondents replied lack of resources; poverty, and drought respectively were the driving factors. Among the respondents in each kebeles 79.5%, 58.3%, and 5.6% of the residents in Dendema, Agidora, and Erer Ebada kebeles respectively replied demographic change as a cause. The residents’ reliance on the resource varies. For example, 55.9%, 52.6%, and 46.7% of the respondents depended on grazing land,water resources, and farming, respectively, and conflicted with the sanctuary. Based on research results, the following inference is drawn; the current resource use conflict can be mitigated through boundary re-demarcation of the sanctuary and creation ofalternative means of community livelihoods in collaboration with the concerned stakeholders along with law enforcement and community engagements.
The Board of Commissioners Moderates Cash Holding and Profitability on Earnings Management
Authors: Aminul Amin Retno Mayasari dan
Published: October 2024

One of the parameters that isused as a reference for investors and shareholders in making financial decisions is profit information in the company's financial reports. The assumption that companies with stable profits reflect optimal performance and have low investment risk encourages managers to make efforts to provide a good picture of performance, one of which is by carrying out earnings management.Deviant earnings management practices are carried out when information asymmetry occurs which arises from moral hazard and encourages management to behave opportunistically, resulting in poor earnings management, which is carried out in an inadequate manner.Earnings management is influenced by several factors, including cash holding, profitability and the board of commissioners. This research aims to examine the influence of cash holding and profitability through the interaction of the board of commissioners which is proportional to the proportion of independent board of commissioners as an internal mechanism for Good Corporate Governance within the company. The population used is all manufacturing companies listed on the Indonesia Stock Exchange, using purposive sampling to obtain 50 selected companies in the 2020-2023 observation period, with a total data sample of 200. Moderated Regression Analysis (MRA) is used as a technique to test the relationship between variables.The test results show that partially cash holding, profitability and the board of commissioners have a significant effect on earnings management. The test results alsoshow that the independent board of commissioners is able to moderate cash holding and profitability on earnings management.
The Influence of Autocratic, Participatory, and Delegation Leadership Styles on The Work Motivation of TNI ADMembersat Yonif 100/PS, Military Regional Command I/Bukit Barisan
Authors: Syah Aditiya Muhammad Tantio , Rachman Abdul , Wahyudi Sigit , Khannanah Sulafah Fathin
Published: October 2024

This research aims to analyze the autocratic, participative, and delegative leadership styles on the motivation of the Indonesian National Army (TNI) Army (AD) personnel in Yonif 100/PS Kodam I or Bukit Barisan. This research is based on the significance of leadership styles in increasing the motivation and ability of personnel in the military area. Each leadership style has a different impact on the enthusiasm for activities and the effectiveness of the organization in carrying out their duties. This research examines how each leadership style authoritarian, participative, and delegative influences the motivation of the organization's activities, and the factors that may mediate or moderate the effects. In addition, this research aims to identify the most effective leadership style in increasing the motivation of personnel activities in Yonif 100/PS. A quantitative approach was used in this research, with data collection through questionnaires distributed to the Indonesian National Army (TNI) Army (AD) personnel in Yonif 100/PS. Data analysis was attempted using statistical methods to test the relationship between leadership style variables and motivation. The research results prove that participative leadership style has a significant positive impact on the motivation of organizational activities, compared to authoritarian and delegative leadership styles. Authoritarian leadership style tends to reduce motivation of activities, while delegative style has various effects related to the atmosphere and character of personnel. The area of activity and organizational culture are also found to influence the relationship between leadership style and work motivation. This research recommends the application of participative leadership style to increase the motivation of Indonesian National Army (TNI) Army (AD) personnel in Yonif 100/PS. This research provides meaningful participation for the development of efficient leadership strategies in the military context and becomes a reference for leaders in creating a more productive and harmonious work environment.
Analysis of the Influence of Accountability, Transparency and Supervision on the Public Service Performance of RSUD TC Hillers Maumere
Authors: Gonzales Rikardus , Alvano  , Christian Stevano
Published: October 2024

This research aims to 1)describe the variables of accountability, transparency, supervision and public service performance of RSUD TC Hillers. 2) analyze the influence of accountability and transparency as well as supervision on the performance of public service of RSUD TC Hillers. 3) analyze the variables that have a dominant influence among the variables of accountability and transparency as well as supervision on the performance of public service of RSUD TC Hillers. The sample in this study was 60 hospital visitors. The data analysis technique in this study used multiple linear regression analysis. The results of the study showed that accountability, transparency, and supervision simultaneously influenced the performance of public service. Accountability, transparency and supervision partially influenced the performance of public service and supervision had a dominant influence on the performance of public service of RSUD TC Hillers Maumere.