bluuebunny/crossref_metadata_2025 huggingface dataset:
Resilience through total defence: Towards a shared security culture in the Nordic–Baltic region?
Authors: Wrange Jana , Bengtsson Rikard , Brommesson Douglas
Published: April 2024

This article investigates the defence policies of the Nordic and Baltic countries from the perspective of shared security culture. To that end, the article analyses conceptualisations of total defence and resilience in a comparative perspective and inquires into existing and prospective regional cooperation in this area, in order to determine to what degree there exists a common security culture based on shared norms and identities and manifested in practices of security cooperation. The study, which draws on 19 interviews with civil servants from the eight states of the region, shows that while there is fertile ground for a shared security culture to emerge, thus far, due to variations in conceptualisations, threat perceptions, and interaction preferences, only three Nordic states show clear signs of a shared security culture. The study contributes to existing research by situating the concept of resilience in (total) defence discourses; by expanding the theoretical work on security culture to an international context; and by offering a unique empirical account of the process of (re)building total defence policies in a region crucial to European security.
A systematic review of reviews on the advantages of mHealth utilization in mental health services: A viable option for large populations in low-resource settings
Authors: Khosravi Mohsen , Azar Ghazaleh
Published: April 2024

Global mental health services face challenges such as stigma and a shortage of trained professionals, particularly in low- and middle-income countries, which hinder access to high-quality care. Mobile health interventions, commonly referred to as mHealth, have shown to have the capacity to confront and solve most of the challenges within mental health services. This paper conducted a comprehensive investigation in 2024 to identify all review studies published between 2000 and 2024 that investigate the advantages of mHealth in mental health services. The databases searched included PubMed, Scopus, Cochrane and ProQuest. The quality of the final papers was assessed and a thematic analysis was performed to categorize the obtained data. 11 papers were selected as final studies. The final studies were considered to be of good quality. The risk of bias within the final studies was shown to be in a convincing level. The main advantages of mHealth interventions were categorized into four major themes: ‘accessibility, convenience and adaptability’, ‘patient-centeredness’, ‘data insights’ and ‘efficiency and effectiveness’. The findings of the study suggested that mHealth interventions can be a viable and promising option for delivering mental health services to large and diverse populations, particularly in vulnerable groups and low-resource settings.
Comment on: Fürsich et al., 2023, Miocene instead of Jurassic: the importance of sound fieldwork for paleontological data analysis
Authors: Das Shiladri S. , Saha Sandip , Bardhan Subhendu , Mondal Subhronil , Paul Shubhabrata , Mallick Sumanta , Saha Ranita , Allmon Warren D.
Published: April 2024

We published a series of papers regarding the oldest turritellids, naticids, their paleoecological interaction, and gastropod biozonation, which are of Oxfordian in age, from the Jhura pond section, Kutch, western India. Recently, an Oxfordian age was challenged by Fürsich et al. (2023) and they argued for a Cenozoic age. The authors reproduced a local geological map based on regional data where the Jhura pond section sediments were overlying the Bhuj Formation. In the original regional data, there was no Bhuj Formation and the introduction of the Bhuj Formation served to show that Jhura pond section sediments were “allochthonous”. Other lines of argument against our conclusions (e.g., identification of associated bivalve fauna, foraminiferal assemblage, and geological context) were brought forward. There were additional inconsistencies, such as the reworking of Oxfordian fossils, in their comment/opinion pieces. The only hard evidence was the report of a microfaunal assemblage, but the taxa were identified at the generic level and most of the genera appear in the Jurassic or even earlier.

Here we provide detailed and concrete evidence explaining features at the Jhura pond section, such as the subvertical nature of the beds, the ooid-bearing lithologies, the presence of various Oxfordian fossils, the difference in turritellids, naticid assemblages, and differences in the diversity curves between the present beds and the lower Miocene Chhasra Formation of Kutch. Detailed paleoecological analyses (both gastropods and bivalves) speak for two paleocommunities. We, therefore, reiterate that the present Jhura pond section sediments are Oxfordian in age and validate all the interpretations and conclusions that we have made in our previous papers.
Miocene instead of Jurassic: the importance of sound fieldwork for paleontological data analysis—a reply
Authors: Fürsich Franz T. , Bhosale Suraj , Alberti Matthias , Pandey Dhirendra K.
Published: April 2024

In their detailed comments, Das et al. (2023) try to discount our arguments that the strata cropping out at the so-called Jhura pond locality are not Late Jurassic in age but Miocene. We wrote this paper (Fürsich et al., 2023) because of the far-reaching conclusions that have been drawn from the molluscan fauna at that locality, in particular with respect to the evolution of turritellid gastropods and the evolution of drilling predation by naticid gastropods. We still maintain that the beds containing abundant turritellids are not Jurassic but Neogene, most probably Miocene, in age. In no way do we contest the various analyses on the material collected from the outcrop by the authors, but just the erroneous age assignment of the strata. In order to keep this reply short, we support our point by referring to just to two aspects: the position of the outcrop and the composition of the fauna. Rather than refuting each of the other arguments of Das et al. (2023), we think that a joint visit to the locality would be more productive for arriving at a consensus on the origin and age of the fauna of the Jhura pond locality.
RADIOCARBON AGES OF PLANT REMAINS IN MASSIVE GROUND ICE AND UNDERLYING SEDIMENTS OF THE BARROW PERMAFROST TUNNEL, ALASKA
Authors: Iwahana Go , Uchida Masao , Horiuchi Kazuho , Deming Jody , Eicken Hajo , Ohno Hiroshi , Mantoku Kanako , Kobayashi Toshiyuki , Saito Kazuyuki
Published: April 2024

Massive ground ice found in the Barrow Permafrost Tunnel at 3–7 m depths from the surface has been interpreted as an ice wedge and used to reconstruct early Holocene environmental changes. To better understand the development of this ground ice, we conducted radiocarbon dating for 34 samples of plant remains from the massive ground ice and underlying sediment layer. A significantly large gap in the measured radiocarbon ages (more than 24 ka) between massive ice and the underlying sediment layer throughout the tunnel profile suggested at least two possibilities. One is that the lower and older sediment layer had thrust upwards at the boundary between intruding ice wedge and adjacent sediment, and the growing ice had pushed the sediment sideways. Another is that erosional events had removed surface materials at about 12–36 ka BP (14–41 cal ka BP) before the overlaying sediment layer with massive ground ice developed. The overall distribution of radiocarbon ages from the massive ice supported the ice-wedge hypothesis as a formation mechanism, although our results showed several age inversions and large fluctuations. Dating of densely spaced samples revealed two ground-ice regions with similar ages around 11–11.5 and 10–10.5 ka BP divided by a relatively narrow region of transitional ages along the tunnel long-axis. This distribution may be explained by a possible misalignment between the sampling direction and the ice-wedge growth line or by intermittent ice growth with repeated cracking at more random locations than the classic ice-wedge growth model suggested.
Caitlin Vincent, Digital Scenography in the Twenty-First Century, Ashgate Interdisciplinary Studies in Opera -
Caitlin Vincent, Digital Scenography in the Twenty-First Century, Ashgate Interdisciplinary Studies in Opera Abingdon: Routledge, 2022. 212 pp. ISBN 9780367553920 (hard cover). DOI: 10.4324/9781003093305 (ebook)
Authors: Rewa Natalie
Published: April 2024

It is June 2022 and the premiere of R.U.R. Torrent of Light, a multimedia opera, in Toronto is enthralling audiences. Inspired by Karel Čapek’s play that introduced the word ‘robot’ into 20th-century vocabulary, composer Nicole Lizée and librettist and playwright Nicholas Billon have conceived a science-fiction opera for our current fascination with AI (artificial intelligence). The production by Toronto’s Tapestry Opera Theatre is in partnership with the research and creation of new technologies at the Social Body Lab and the Digital Futures Initiatives at Ontario College of Art & Design University. It has been conceived to embed technologies into the scenographic dramaturgy as projections, wearable art and spatialisation of sound and light through the costuming and neologisms in instrumentation to create a ‘unique electronica-classical sound’ of the neo-futurist worlding. After the hiatus of the last two years, this live performance highlights our growing recognition of scenographic vocabularies of programmable performance affecting behaviours, as well as expanded definitions of sound and digital integration as contemporary opera. Such interdisciplinarity has often brought the spectator into fresh relationships with opera in performance, thereby activating the event of spectatorship.
Bleeding Control Protections Within US Good Samaritan Laws
Authors: Levy Matthew J. , Wend Christopher M. , Flemming William P. , Lazieh Antoin , Rosenblum Andrew J. , Pineda Candace M. , Wolfberg Douglas M. , Jenkins Jennifer Lee , Goolsby Craig A. , Margolis Asa M.
Published: April 2024

Introduction:

In the United States, all 50 states and the District of Columbia have Good Samaritan Laws (GSLs). Designed to encourage bystanders to aid at the scene of an emergency, GSLs generally limit the risk of civil tort liability if the care is rendered in good faith. Nation-wide, a leading cause of preventable death is uncontrolled external hemorrhage. Public bleeding control initiatives aim to train the public to recognize life-threatening external bleeding, perform life-sustaining interventions (including direct pressure, tourniquet application, and wound packing), and to promote access to bleeding control equipment to ensure a rapid response from bystanders.

Methods:

This study sought to identify the GSLs in each state and the District of Columbia to identify what type of responder is covered by the law (eg, all laypersons, only trained individuals, or only licensed health care providers) and if bleeding control is explicitly included or excluded in their Good Samaritan coverage.

Results:

Good Samaritan Laws providing civil liability qualified immunity were identified in all 50 states and the District of Columbia. One state, Oklahoma, specifically includes bleeding control in its GSLs. Six states – Connecticut, Illinois, Kansas, Kentucky, Michigan, and Missouri – have laws that define those covered under Good Samaritan immunity, generally limiting protection to individuals trained in a standard first aid or resuscitation course or health care clinicians. No state explicitly excludes bleeding control from their GSLs, and one state expressly includes it.

Conclusion:

Nation-wide across the United States, most states have broad bystander coverage within GSLs for emergency medical conditions of all types, including bleeding emergencies, and no state explicitly excludes bleeding control interventions. Some states restrict coverage to those health care personnel or bystanders who have completed a specific training program. Opportunity exists for additional research into those states whose GSLs may not be inclusive of bleeding control interventions.
Understanding the First Paralogism: A Friendly Disagreement
Authors: Kitcher Patricia
Published: April 2024

My comments focus on Proops’s treatment of the Paralogisms. I agree with many aspects of his discussion, including his views about the project of Rational Psychology and his analyses of how, exactly, the arguments of the Paralogisms are defective in form, but I disagree with his interpretation of the First Paralogism. I argue that the source of confusion that Kant diagnoses is not the grammatical distribution of ‘I’ as singular, but the fact that the I-representation is both empty and necessary for cognition.
Ian Proops: Kant on Transcendental Freedom (The Fiery Test of Critique: Chs. 11–12)
Authors: Wood Allen
Published: April 2024

Kant’s position on the problem of free will can be perplexing and frustrating: all the real questions about human agential capacities or even about issues of moral imputability are empirical questions, which have empirical answers. But there remains a metaphysical or transcendental problem about the possibility of freedom, which is forever insoluble. Ian Proops’ discussion in The Fiery Test of Critique is to be commended for displaying the rare virtue of appreciating this last point and presenting Kant’s position about it accurately. The only questionable part has to do with the standard terminology – ‘determinism’, ‘libertarianism’, ‘compatibilism’, and ‘incompatibilism’. I argue that it would be better to say, as Kant does, and Proops also does most of the time, that practical freedom, hence transcendental freedom, must be presupposed whenever we act or even judge, but how freedom is possible is both unknowable and even incomprehensible to us.
Working Oneself Up and Universal Basic Income
Authors: Sticker Martin
Published: April 2024

I respond to a challenge raised by Jordan Pascoe: Kant’s conception of obtaining full citizenship through working oneself up necessarily condemns some people to passive citizenship. I argue that we should not focus on work to establish universal full citizenship. Rather, a Universal Basic Income, an income paid regularly to everyone and without conditions, can secure everyone’s full citizenship. Moreover, I argue that such a scheme is more Kantian in nature than hitherto assumed.
Using Baseflow Ensembles for Hydrologic Hysteresis Characterization in Humid Basins of Southeastern China
Authors: Chen Hao , Huang Saihua , Xu Yue‐Ping , Teegavarapu Ramesh S. V. , Guo Yuxue , Nie Hui , Xie Huawei
Published: April 2024

Baseflow plays a vital role in protecting the environment and ensuring a stable water supply for farming. There are still gaps in the current understanding of baseflow convergence rates in the humid region due to the abundance of rainfall and the high‐water table. Therefore, this study focused on the evolution and hysteresis characteristics of baseflow in humid basins of southeastern China. The baseflow ensemble simulation (BES) method was established to improve the reliability and applicability of baseflow simulation. We suggest a way of differentiating the wet and dry seasons based on the multi‐year average monthly baseflow index (BFI) to determine the intra‐annual distribution of water effectively and simply. The hydrological hysteresis effect of baseflow on precipitation is revealed by characterizing baseflow response to precipitation under precipitation events during wet and dry seasons. A methodology for assessing the performance of baseflow simulation was proposed from observations of streamflow and precipitation. We found that the BES method performed better in baseflow simulation than other single separation methods. Using the BES method, the lag time of baseflow to precipitation during the wet and dry seasons was found to be 3.09 and 4.04 days after utilizing the BFI to divide the hydrological situation into wet and dry seasons. Additionally, precipitation had nearly twice as much intensity influence on baseflow during the dry season compared to the wet season. These findings have significant ramifications for the use, management, and planning of water resources in humid areas of China.
Identification of high lead exposure locations in Ohio at the census tract scale using a generalizable geospatial hotspot approach
Authors: Stanek Lindsay W. , Xue Jianping , Zartarian Valerie G. , Poulakos Antonios G. , Tornero-Velez Rogelio , Snyder Emily G. , Walts Alan , Triantafillou Kathy
Published: April 2024

Background

Lead is a persistent, ubiquitous pollutant whose historical sources have been largely addressed through regulation and voluntary actions. The United States (U.S.) has achieved significant decreases in children’s blood lead levels (BLL) over the past 40 years; however, there is no known safe level of Pb exposure. Some communities continue to be disproportionately impacted by exposure to Pb, including Black children and families living in older homes.

Objective

To identify Ohio (OH) census tracts with children exposed to Pb and evaluate potential exposure determinants.

Methods

We obtained individual children’s blood Pb data from 2005–2018 in OH. The percent of children with elevated BLL (EBLL) was calculated for OH census tracts using three blood Pb reference values (3.5, 5, and 10 µg/dL). Getis-Ord Gi* geospatial hotspot or top 20th percentile methodologies were then applied to identify “hotspots.” Findings across multiple time periods and blood Pb reference values were evaluated and compared with existing Pb exposure indices and models.

Results

Consistency was observed across different blood Pb reference values, with the main hotspots identified at 3.5 µg/dL, also identified at 5 and 10 µg/dL. Substantial gains in public health were demonstrated, with the biggest decreases in the number of census tracts with EBLL observed between 2008–2010 and 2011–2013. Across OH, 355 census tracts (of 2850) were identified as hotspots across 17 locations, with the majority in the most populated cites. Generally, old housing and sociodemographic factors were indicators of these EBLL hotspots. A smaller number of hotspots were not associated with these exposure determinants. Variables of race, income, and education level were all strong predictors of hotspots.

Impact statement

The Getis-Ord Gi* geospatial hotspot analysis can inform local investigations into potential Pb exposures for children living in OH. The successful application of a generalizable childhood blood Pb methodology at the census tract scale provides results that are more readily actionable. The moderate agreement of the measured blood Pb results with public Pb indices provide confidence that these indices can be used in the absence of available blood Pb surveillance data. While not a replacement for universal blood Pb testing, a consistent approach can be applied to identify areas where Pb exposure may be problematic.
Unique transcriptional signatures correlate with behavioral and psychological symptom domains in Alzheimer’s disease
Authors: Fisher Daniel W. , Dunn Jeffrey T. , Keszycki Rachel , Rodriguez Guadalupe , Bennett David A. , Wilson Robert S. , Dong Hongxin
Published: April 2024

Despite the significant burden, cost, and worse prognosis of Alzheimer’s disease (AD) with behavioral and psychological symptoms of dementia (BPSD), little is known about the molecular causes of these symptoms. Using antemortem assessments of BPSD in AD, we demonstrate that individual BPSD can be grouped into 4 domain factors in our cohort: affective, apathy, agitation, and psychosis. Then, we performed a transcriptome-wide analysis for each domain utilizing bulk RNA-seq of post-mortem anterior cingulate cortex (ACC) tissues. Though all 4 domains are associated with a predominantly downregulated pattern of hundreds of differentially expressed genes (DEGs), most DEGs are unique to each domain, with only 22 DEGs being common to all BPSD domains, includingTIMP1. Weighted gene co-expression network analysis (WGCNA) yielded multiple transcriptional modules that were shared between BPSD domains or unique to each domain, and NetDecoder was used to analyze context-dependent information flow through the biological network. For the agitation domain, we found that all DEGs and a highly associated transcriptional module were functionally enriched for ECM-related genes includingTIMP1, TAGLN, andFLNA. Another unique transcriptional module also associated with the agitation domain was enriched with genes involved in post-synaptic signaling, includingDRD1, PDE1B, CAMK4, andGABRA4. By comparing context-dependent changes in DEGs between cases and control networks,ESR1andPARK2were implicated as two high-impact genes associated with agitation that mediated significant information flow through the biological network. Overall, our work establishes unique targets for future study of the biological mechanisms of BPSD and resultant drug development.
Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1α/PPARα pathway-mediated fatty acid oxidation
Authors: Li Linxia , Liu Yanqi , Zhi Na , Ji Yaoxuan , Xu Jialing , Mao Guoyun , Wang Yazhou , Ma Jin , Wang Yunying
Published: April 2024

Hypoxic preconditioning (HPC) has been shown to improve organ tolerance to subsequent severe hypoxia or ischemia. However, its impact on intestinal ischemic injury has not been well studied. In this study, we evaluated the effects of HPC on intestinal ischemia in rats. Intestinal rehabilitation, levels of fatty acid oxidation (FAO) by-products, intestinal stem cells (ISCs), levels of hypoxia-inducible factor 1 subunit α (HIF-1α) and its downstream genes such as peroxisome proliferator-activated receptor α (PPARα), and carnitine palmitoyltransferase 1a (CPT1A) were assessed at distinct time intervals following intestinal ischemia with or without the interference of HIF-1α. Our data showed that HPC facilitates the restoration of the intestinal structure and enhances the FAO, by boosting intestinal stem cells. Additionally, HIF-1α, PPARα, and CPT1A mRNA and their protein levels were generally up-regulated in the small intestine of HPC rats as compared to the control group. Our vitro experiment also shows low-oxygen induces highly levels of HIF-1α and its downstream genes, with a concurrent increase in FAO products in IEC-6 cells. Furthermore, the above phenomenon could be reversed by silencing HIF-1α. In conclusion, we hypothesize that HPC can stimulate the activation of intestinal stem cells via HIF-1α/PPARα pathway-mediated FAO, thereby accelerating the healing process post ischemic intestinal injury.
Architecture and regulation of filamentous human cystathionine beta-synthase
Authors: McCorvie Thomas J. , Adamoski Douglas , Machado Raquel A. C. , Tang Jiazhi , Bailey Henry J. , Ferreira Douglas S. M. , Strain-Damerell Claire , Baslé Arnaud , Ambrosio Andre L. B. , Dias Sandra M. G. , Yue Wyatt W.
Published: April 2024

Cystathionine beta-synthase (CBS) is an essential metabolic enzyme across all domains of life for the production of glutathione, cysteine, and hydrogen sulfide. Appended to the conserved catalytic domain of human CBS is a regulatory domain that modulates activity by S-adenosyl-L-methionine (SAM) and promotes oligomerisation. Here we show using cryo-electron microscopy that full-length human CBS in the basal and SAM-bound activated states polymerises as filaments mediated by a conserved regulatory domain loop. In the basal state, CBS regulatory domains sterically block the catalytic domain active site, resulting in a low-activity filament with three CBS dimers per turn. This steric block is removed when in the activated state, one SAM molecule binds to the regulatory domain, forming a high-activity filament with two CBS dimers per turn. These large conformational changes result in a central filament of SAM-stabilised regulatory domains at the core, decorated with highly flexible catalytic domains. Polymerisation stabilises CBS and reduces thermal denaturation. In PC-3 cells, we observed nutrient-responsive CBS filamentation that disassembles when methionine is depleted and reversed in the presence of SAM. Together our findings extend our understanding of CBS enzyme regulation, and open new avenues for investigating the pathogenic mechanism and therapeutic opportunities for CBS-associated disorders.
Monoclonal antibodies targeting sites in respiratory syncytial virus attachment G protein provide protection against RSV-A and RSV-B in mice
Authors: Lee Youri , Klenow Laura , Coyle Elizabeth M. , Grubbs Gabrielle , Golding Hana , Khurana Surender
Published: April 2024

Currently, only Palivizumab and Nirsevimab that target the respiratory syncytical virus (RSV) fusion protein are licensed for pre-treatment of infants. Glycoprotein-targeting antibodies may also provide protection against RSV. In this study, we generate monoclonal antibodies from mice immunized with G proteins from RSV-A2 and RSV-B1 strains. These monoclonal antibodies recognize six unique antigenic classes (G0-G5). None of the anti-G monoclonal antibodies neutralize RSV-A2 or RSV-B1 in vitro. In mice challenged with either RSV-A2 line 19 F or RSV-B1, one day after treatment with anti-G monoclonal antibodies, all monoclonal antibodies reduce lung pathology and significantly reduce lung infectious viral titers by more than 2 logs on day 5 post-RSV challenge. RSV dissemination in the lungs was variable and correlated with lung pathology. We demonstrate new cross-protective anti-G monoclonal antibodies targeting multiple sites including conformation-dependent class G0 MAb 77D2, CCD-specific class G1 MAb 40D8, and carboxy terminus of CCD class G5 MAb 7H11, to support development of G-targeting monoclonal antibodies against RSV.
Legume rhizodeposition promotes nitrogen fixation by soil microbiota under crop diversification
Authors: Qiao Mengjie , Sun Ruibo , Wang Zixuan , Dumack Kenneth , Xie Xingguang , Dai Chuanchao , Wang Ertao , Zhou Jizhong , Sun Bo , Peng Xinhua , Bonkowski Michael , Chen Yan
Published: April 2024

Biological nitrogen fixation by free-living bacteria and rhizobial symbiosis with legumes plays a key role in sustainable crop production. Here, we study how different crop combinations influence the interaction between peanut plants and their rhizosphere microbiota via metabolite deposition and functional responses of free-living and symbiotic nitrogen-fixing bacteria. Based on a long-term (8 year) diversified cropping field experiment, we find that peanut co-cultured with maize and oilseed rape lead to specific changes in peanut rhizosphere metabolite profiles and bacterial functions and nodulation. Flavonoids and coumarins accumulate due to the activation of phenylpropanoid biosynthesis pathways in peanuts. These changes enhance the growth and nitrogen fixation activity of free-living bacterial isolates, and root nodulation by symbiotic Bradyrhizobium isolates. Peanut plant root metabolites interact with Bradyrhizobium isolates contributing to initiate nodulation. Our findings demonstrate that tailored intercropping could be used to improve soil nitrogen availability through changes in the rhizosphere microbiome and its functions.
Pd/NiMoO4/NF electrocatalysts for the efficient and ultra-stable synthesis and electrolyte-assisted extraction of glycolate
Authors: Shi Kai , Si Di , Teng Xue , Chen Lisong , Shi Jianlin
Published: April 2024

Electrocatalytic conversion of organic small molecules is a promising technique for value-added chemical productions but suffers from high precious metal consumption, poor stability of electrocatalysts and tedious product separation. Here, a Pd/NiMoO4/NF electrocatalyst with much lowered Pd loading amount (3.5 wt.%) has been developed for efficient, economic, and ultra-stable glycolate synthesis, which shows high Faradaic efficiency (98.9%), yield (98.8%), and ultrahigh stability (1500 h) towards electrocatalytic ethylene glycol oxidation. Moreover, the obtained glycolic acid has been converted to value-added sodium glycolate by in-situ acid-base reaction in the NaOH electrolyte, which is atomic efficient and needs no additional acid addition for product separation. Moreover, the weak adsorption of sodium glycolate on the catalyst surface plays a significant role in avoiding excessive oxidation and achieving high selectivity. This work may provide instructions for the electrocatalyst design as well as product separation for the electrocatalytic conversions of alcohols.
A population-based cohort study of longitudinal change of high-density lipoprotein cholesterol impact on gastrointestinal cancer risk
Authors: Nam Su Youn , Jo Junwoo , Cho Chang-Min
Published: April 2024

High-density Lipoprotein Cholesterol (HDL-C) levels have been associated with cancer. In this observational population-based cohort study using data from the Korean National Health Insurance Service system, we investigate the impact of longitudinal changes in HDL-C levels on gastrointestinal cancer risk. Individuals who underwent health examinations in 2010 and 2014 were followed-up through 2021. Among 3.131 million, 40696 gastric, 35707 colorectal, 21309 liver, 11532 pancreatic, 4225 gallbladder, and 7051 biliary cancers are newly detected. The persistent low HDL-C group increases the risk of gastric, liver, and biliary cancer comparing to persistent normal HDL-C group. HDL-C change from normal to low level increases the risk for gastric, colorectal, liver, pancreatic, gallbladder, and biliary cancers. Effects of HDL-C change on the gastrointestinal cancer risk are also modified by sex and smoking status. HDL-C changes affect the gastric and gallbladder cancer risk in age ≥60 years and the pancreatic and biliary cancer risk in age <60 years. Here, we show persistently low HDL-C and normal-to-low HDL-C change increase gastrointestinal cancer risk with discrepancies by sex, smoking status, and age.
Integrated mechanical computing for autonomous soft machines
Authors: Byun Junghwan , Pal Aniket , Ko Jongkuk , Sitti Metin
Published: April 2024

Mechanical computing offers a new modality to formulate computational autonomy in intelligent matter or machines without any external powering or active elements. Transition (or solitary) waves, induced by nonreciprocity in mechanical metamaterials comprising a chain of bistable elements, have proven to be a key ingredient for dissipation-free transmission and computation of mechanical information. However, advanced processing of mechanical information in existing designs is hindered by its dissipation when interacting with networked logic gates. Here, we present a metamaterial design strategy that allows non-dispersive mechanical solitary waves to compute multi-level cascaded logic functions, termed ‘integrated mechanical computing’, by propagating through a network of structurally heterogeneous computing units. From a perspective of characteristic potential energy, we establish an analytical framework that helps in understanding the solitary wave-based mechanical computation, and governs the mechanical design of key determinants for realizing cascaded logic computation, such as soliton profile and logic elements. The developed integrated mechanical computing systems are shown to receive, transmit and compute mechanical information to actuate intelligent soft machine prototypes in a seamless and integrated manner. These findings would pave the way for future intelligent robots and machines that perform computational operations between various non-electrical environmental inputs.
Paired electrocatalysis unlocks cross-dehydrogenative coupling of C(sp3)-H bonds using a pentacoordinated cobalt-salen catalyst
Authors: Liu Ke , Lei Mengna , Li Xin , Zhang Xuemei , Zhang Ying , Fan Weigang , Li Man-Bo , Zhang Sheng
Published: April 2024

Cross-dehydrogenative coupling of C(sp3)-H bonds is an ideal approach for C(sp3)-C(sp3) bond construction. However, conventional approaches mainly rely on a single activation mode by either stoichiometric oxidants or electrochemical oxidation, which would lead to inferior selectivity in the reaction between similar C(sp3)-H bonds. Herein we describe our development of a paired electrocatalysis strategy to access an unconventional selectivity in the cross-dehydrogenative coupling of alcoholic α C(sp3)-H with allylic (or benzylic) C-H bonds, which combines hydrogen evolution reaction catalysis with hydride transfer catalysis. To maximize the synergistic effect of the catalyst combinations, a HER catalyst pentacoordinated Co-salen is disclosed. The catalyst displays a large redox-potential gap (1.98 V) and suitable redox potential. With the optimized catalyst combination, an electrochemical cross-dehydrogenative coupling protocol features unconventional chemoselectivity (C-C vs. C-O coupling), excellent functional group tolerance (84 examples), valuable byproduct (hydrogen), and high regio- and site-selectivity. A plausible reaction mechanism is also proposed to rationalize the experimental observations.
Switching the spin cycloid in BiFeO3 with an electric field
Authors: Meisenheimer Peter , Moore Guy , Zhou Shiyu , Zhang Hongrui , Huang Xiaoxi , Husain Sajid , Chen Xianzhe , Martin Lane W. , Persson Kristin A. , Griffin Sinéad , Caretta Lucas , Stevenson Paul , Ramesh Ramamoorthy
Published: April 2024

Bismuth ferrite (BiFeO3) is a multiferroic material that exhibits both ferroelectricity and canted antiferromagnetism at room temperature, making it a unique candidate in the development of electric-field controllable magnetic devices. The magnetic moments in BiFeO3 are arranged into a spin cycloid, resulting in unique magnetic properties which are tied to the ferroelectric order. Previous understanding of this coupling has relied on average, mesoscale measurements. Using nitrogen vacancy-based diamond magnetometry, we observe the magnetic spin cycloid structure of BiFeO3 in real space. This structure is magnetoelectrically coupled through symmetry to the ferroelectric polarization and this relationship is maintained through electric field switching. Through a combination of in-plane and out-of-plane electrical switching, coupled with ab initio studies, we have discovered that the epitaxy from the substrate imposes a magnetoelastic anisotropy on the spin cycloid, which establishes preferred cycloid propagation directions. The energy landscape of the cycloid is shaped by both the ferroelectric degree of freedom and strain-induced anisotropy, restricting the spin spiral propagation vector to changes to specific switching events.
Aggregation induced emission dynamic chiral europium(III) complexes with excellent circularly polarized luminescence and smart sensors
Authors: Li Yun-Lan , Wang Hai-Ling , Zhu Zhong-Hong , Wang Yu-Feng , Liang Fu-Pei , Zou Hua-Hong
Published: April 2024

The synthesis of dynamic chiral lanthanide complex emitters has always been difficult. Herein, we report three pairs of dynamic chiral EuIII complex emitters (R/S-Eu-R-1, R = Et/Me; R/S-Eu-Et-2) with aggregation-induced emission. In the molecular state, these EuIII complexes have almost no obvious emission, while in the aggregate state, they greatly enhance the EuIII emission through restriction of intramolecular rotation and restriction of intramolecular vibration. The asymmetry factor and the circularly polarized luminescence brightness are as high as 0.64 (5D0 → 7F1) and 2429 M−1cm−1 of R-Eu-Et-1, achieving a rare double improvement. R-Eu-Et-1/2 exhibit excellent sensing properties for low concentrations of CuII ions, and their detection limits are as low as 2.55 and 4.44 nM, respectively. Dynamic EuIII complexes are constructed by using chiral ligands with rotor structures or vibration units, an approach that opens a door for the construction of dynamic chiral luminescent materials.
VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response
Authors: Thisted Thomas , Smith F. Donelson , Mukherjee Arnab , Kleschenko Yuliya , Feng Feng , Jiang Zhi-Gang , Eitas Timothy , Malhotra Kanam , Biesova Zuzana , Onumajuru Adejumoke , Finley Faith , Cifuentes Anokhi , Zhang Guolin , Martin Gaëlle H. , Takeuchi Yoshiko , Thiam Kader , Schreiber Robert D. , van der Horst Edward H.
Published: April 2024

VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VISTA antibodies. Here we demonstrate that SNS-101, a newly developed pH-selective VISTA antibody, addresses these challenges. Structural and biochemical analyses confirmed the pH-selectivity and unique epitope targeted by SNS-101. These properties confer favorable pharmacokinetic and safety profiles on SNS-101. In syngeneic tumor models utilizing human VISTA knock-in mice, SNS-101 shows in vivo efficacy when combined with a PD-1 inhibitor, modulates cytokine and chemokine signaling, and alters the tumor microenvironment. In summary, SNS-101, currently in Phase I clinical trials, emerges as a promising therapeutic biologic for a wide range of patients whose cancer is refractory to current immunotherapy regimens.
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
Authors: Gonzalez-Ortiz Fernando , Kirsebom Bjørn-Eivind , Contador José , Tanley Jordan E. , Selnes Per , Gísladóttir Berglind , Pålhaugen Lene , Suhr Hemminghyth Mathilde , Jarholm Jonas , Skogseth Ragnhild , Bråthen Geir , Grøndtvedt Gøril , Bjørnerud Atle , Tecelao Sandra , Waterloo Knut , Aarsland Dag , Fernández-Lebrero Aida , García-Escobar Greta , Navalpotro-Gómez Irene , Turton Michael , Hesthamar Agnes , Kac Przemyslaw R. , Nilsson Johanna , Luchsinger Jose , Hayden Kathleen M. , Harrison Peter , Puig-Pijoan Albert , Zetterberg Henrik , Hughes Timothy M. , Suárez-Calvet Marc , Karikari Thomas K. , Fladby Tormod , Blennow Kaj
Published: April 2024

Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ pathophysiology but an AD-type neurodegeneration biomarker has been lacking. In this multicenter study (n = 1076), we show that brain-derived tau (BD-tau) in blood increases according to concomitant Aβ (“A”) and neurodegeneration (“N”) abnormalities (determined using cerebrospinal fluid biomarkers); We used blood-based A/N biomarkers to profile the participants in this study; individuals with blood-based p-tau+/BD-tau+ profiles had the fastest cognitive decline and atrophy rates, irrespective of the baseline cognitive status. Furthermore, BD-tau showed no or much weaker correlations with age, renal function, other comorbidities/risk factors and self-identified race/ethnicity, compared with other blood biomarkers. Here we show that blood-based BD-tau is a biomarker for identifying Aβ-positive individuals at risk of short-term cognitive decline and atrophy, with implications for clinical trials and implementation of anti-Aβ therapies.
Bacterial c-di-GMP signaling gene affects mussel larval metamorphosis through outer membrane vesicles and lipopolysaccharides
Authors: Hu Xiao-Meng , Peng Lihua , Wu Jingxian , Wu Guanju , Liang Xiao , Yang Jin-Long
Published: April 2024

Biofilms serve as crucial cues for settlement and metamorphosis in marine invertebrates. Within bacterial systems, c-di-GMP functions as a pivotal signaling molecule regulating both biofilm formation and dispersion. However, the molecular mechanism of how c-di-GMP modulates biofilm-induced larval metamorphosis remains elusive. Our study reveals that the deletion of a c-di-GMP related gene in Pseudoalteromonas marina led to an increase in the level of bacterial c-di-GMP by knockout technique, and the mutant strain had an enhanced ability to produce more outer membrane vesicles (OMVs) and lipopolysaccharides (LPS). The mutant biofilms had higher induction activity for larval metamorphosis in mussels Mytilus coruscus, and OMVs play a major role in the induction activity. We further explored the function of LPS in OMVs. Extracted LPS induced high larval metamorphosis rate, and LPS content were subject to c-di-GMP and LPS-biosynthesis gene. Thus, we postulate that the impact of c-di-GMP on biofilm-induced metamorphosis is mediated through OMVs and LPS.
Coupled cluster finite temperature simulations of periodic materials via machine learning
Authors: Herzog Basile , Gallo Alejandro , Hummel Felix , Badawi Michael , Bučko Tomáš , Lebègue Sébastien , Grüneis Andreas , Rocca Dario
Published: April 2024

Density functional theory is the workhorse of materials simulations. Unfortunately, the quality of results often varies depending on the specific choice of the exchange-correlation functional, which significantly limits the predictive power of this approach. Coupled cluster theory, including single, double, and perturbative triple particle-hole excitation operators, is widely considered the ‘gold standard' of quantum chemistry as it can achieve chemical accuracy for non-strongly correlated applications. Because of the high computational cost, the application of coupled cluster theory in materials simulations is rare, and this is particularly true if finite-temperature properties are of interest for which molecular dynamics simulations have to be performed. By combining recent progress in machine learning models with low data requirements for energy surfaces and in the implementation of coupled cluster theory for periodic materials, we show that chemically accurate simulations of materials are practical and could soon become significantly widespread. As an example of this numerical approach, we consider the calculation of the enthalpy of adsorption of CO2 in a porous material.
Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice
Authors: Zhang Yan , Zhao Lei , Sun Yeqing
Published: April 2024

Transcriptome profiles are sensitive to space stressors and serve as valuable indicators of the biological effects during spaceflight. Herein, we transformed the expression profiles into gene interaction patterns by single-sample networks (SSNs) and performed the integrated analysis on the 301 spaceflight and 290 ground control samples, which were obtained from the GeneLab platform. Specifically, an individual SSN was established for each sample. Based on the topological structures of 591 SSNs, the differentially interacted genes (DIGs) were identified between spaceflights and ground controls. The results showed that spaceflight disrupted the gene interaction patterns in mice and resulted in significant enrichment of biological processes such as protein/amino acid metabolism and nucleic acid (DNA/RNA) metabolism (P-value < 0.05). We observed that the mice exposed to radiation doses within the three intervals (4.66–7.14, 7.592–8.295, 8.49–22.099 mGy) exhibited similar gene interaction patterns. Low and medium doses resulted in changes to the circadian rhythm, while the damaging effects on genetic material became more pronounced in higher doses. The gene interaction patterns in response to space stressors varied among different tissues, with the spleen, lung, and skin being the most responsive to space radiation (P-value < 0.01). The changes observed in gene networks during spaceflight conditions might contribute to the development of various diseases, such as mental disorders, depression, and metabolic disorders, among others. Additionally, organisms activated specific gene networks in response to virus reactivation. We identified several hub genes that were associated with circadian rhythms, suggesting that spaceflight could lead to substantial circadian rhythm dysregulation.
Leggett modes in a Dirac semimetal
Authors: Cuozzo Joseph J. , Yu W. , Davids P. , Nenoff T. M. , Soh D. B. , Pan Wei , Rossi Enrico
Published: April 2024

Experiments have shown that several materials, including MgB2, iron-based superconductors and monolayer NbSe2, are multiband superconductors. Superconducting pairing in multiple bands can give rise to phenomena not available in a single band, including Leggett modes. A Leggett mode is the collective periodic oscillation of the relative phase between the phases of the superconducting condensates formed in the different bands. The experimental observation of Leggett modes is challenging because multiband superconductors are rare and because these modes describe charge fluctuations between bands and therefore are hard to probe directly. Also, the excitation energy of a Leggett mode is often larger than the superconducting gaps, and therefore they are strongly overdamped via relaxation processes into the quasiparticle continuum. Here, we show that Leggett modes and their frequency can be detected in a.c. driven superconducting quantum interference devices. We then use the results to analyse the measurements of such a quantum device, one based on a Dirac semimetal Cd3As2, in which superconductivity is induced by proximity to superconducting Al. These results show the theoretically predicted signatures of Leggett modes, and therefore we conclude that a Leggett mode is present in the two-band superconducting state of Cd3As2.
Physiological data for affective computing in HRI with anthropomorphic service robots: the AFFECT-HRI data set
Authors: Heinisch Judith S. , Kirchhoff Jérôme , Busch Philip , Wendt Janine , von Stryk Oskar , David Klaus
Published: April 2024

In human-human and human-robot interaction, the counterpart influences the human’s affective state. Contrary to humans, robots inherently cannot respond empathically, meaning non-beneficial affective reactions cannot be mitigated. Thus, to create a responsible and empathetic human-robot interaction (HRI), involving anthropomorphic service robots, the effect of robot behavior on human affect in HRI must be understood. To contribute to this understanding, we provide the new comprehensive data set AFFECT-HRI, including, for the first time, physiological data labeled with human affect (i.e., emotions and mood) gathered from a conducted HRI study. Within the study, 146 participants interacted with an anthropomorphic service robot in a realistic and complex retail scenario. The participants’ questionnaire ratings regarding affect, demographics, and socio-technical ratings are provided in the data set. Five different conditions (i.e., neutral, transparency, liability, moral, and immoral) were considered during the study, eliciting different affective reactions and allowing interdisciplinary investigations (e.g., computer science, law, and psychology). Each condition includes three scenes: a consultation regarding products, a request for sensitive personal information, and a handover.