bluuebunny/crossref_metadata_2025 huggingface dataset:
Physiologically based modelling of the antiplatelet effect of aspirin: A tool to characterize drug responsiveness and inform precision dosing
Authors: Giaretta Alberto , Petrucci Giovanna , Rocca Bianca , Toffolo Gianna Maria
Published: August 2022

A computational approach involving mathematical modeling and in silico experiments was used to characterize the determinants of extent and duration of platelet cyclooxygenase (COX)-1 inhibition by aspirin and design precision dosing in patients with accelerated platelet turnover or reduced drug bioavailability. To this purpose, a recently developed physiologically-based pharmacokinetics (PK) and pharmacodynamics (PD) model of low-dose aspirin in regenerating platelets and megakaryocytes, was used to predict the main features and determinants of platelet COX-1 inhibition. The response to different aspirin regimens in healthy subjects and in pathological conditions associated with alterations in aspirin PK (i.e., severely obese subjects) or PD (i.e., essential thrombocytemya patients), were simulated. A model sensitivity analysis was performed to identify the main processes influencing COX-1 dynamics. In silico experiments and sensitivity analyses indicated a major role for megakaryocytes and platelet turnover in determining the extent and duration of COX-1 inhibition by once-daily, low-dose aspirin. They also showed the superiority of reducing the dosing interval vs increasing the once-daily dose in conditions of increased platelet turnover, while suggested specific dose adjustments in conditions of possible reduction in drug bioavailability. In conclusion, the consistency of our model-based findings with experimental data from studies in healthy subjects and patients with essential thrombocythemia supports the potential of our approach for describing the determinants of platelet inhibition by aspirin and informing precision dosing which may guide personalized antithrombotic therapy in different patient populations, especially in those under-represented in clinical trials or in those associated with poor feasibility.
Marriage survival in new married couples: A competing risks survival analysis
Authors: Norouzi Solmaz , Tamiz Roghayeh , Naghizadeh Sahar , Mobasseri Khorshid , Imani Leila , Esmaeili Paria , Hamitalab Raha , Rahmani Fardin , Asghari Jafarabadi Mohammad
Published: August 2022

Background and aim

Marriage is one of the most important phenomena in human life. The survival of the marriage and the impact of various competing factors on the survival is of high importance. This study aimed at utilizing competing risks survival analysis to investigate the marriage survival of new couples in Tabriz.

Methods

In this longitudinal study, a number of 386 individuals who were married and divorced from 1991 to 2017, were selected by random sampling. The registered information was attained from the general registry office of Tabriz. Data analysis was carried out using the Lunn-McNeil procedure and the results were presented using an adjusted hazard ratio (AHR).

Results

The average age of marriage was about 23.9 (SD 6.6) years. The results of multivariate Lunn-McNeil models indicated that for the competing cause of having a relationship with another person (AHRs range: 1.12 to 2.03), the traditional mode of being familiar (AHRs range: 1.55 to 3.39), family weak role in choosing a wife/spouse (AHRs range: 0.25 to 3.25) and the role of moral-religious commitment (AHRs range: 0.37 to 0.47), along with other causes severed the risk of marriage survival reduction.

Conclusion

According to the results of this study in assessing competing risks, we conclude that the decline in marriage survival is a multifactorial phenomenon. Examining the survival of marriage in order to better understand all the dimensions and factors affecting this phenomenon and providing information to counselors and officials can play an important role in increasing marriage survival.
Risk of malignancy in patients with chronic kidney disease
Authors: Tendulkar Ketki K. , Cope Brendan , Dong Jianghu , Plumb Troy J. , Campbell W. Scott , Ganti Apar Kishor
Published: August 2022

Background

Fifteen percent of US adults have chronic kidney disease (CKD). The effect of CKD on the development of different malignancies is unknown. Understanding the effect of CKD on the risk of development of cancer could have important implications for screening and early detection of cancer in these patients.

Methods

Adult CKD patients [estimated GFR (eGFR) <60ml/min/1.73m2] between January 2001 and December 2020 were identified in this single institution study. Patients were divided into four stages of CKD by eGFR. The incidence of cancer and time to development of the first cancer were identified. Multivariable models were used to compare the overall cancer incidence while considering death as a competing risk event and adjusting for relevant covariates (sex, race, diabetes, hypertension, CAD, smoking or not, BMI, and CKD stages). Separate multivariable models of the incidence of cancers were conducted in each age group. Multivariable Cox models were used to fit the overall death adjusting for relevant covariates. Patients were censored at the conclusion of the study period (December 31, 2020). Statistical analysis was performed with SAS software (version 9.4).

Results

Of the 13,750 patients with a diagnosis of CKD in this cohort, 2,758 (20.1%) developed a malignancy. The median time to development of cancer following a diagnosis of CKD was 8.5 years. Factors associated with the risk of developing cancer in CKD patients included increasing age, male sex and worsening chronic kidney disease, while diabetes was associated with a lower risk of malignancy. On multivariate analysis, the factors associated with increased mortality in patients who developed cancer included increasing age, diabetes and lower eGFR.

Conclusion

CKD is an increased risk factor for the development of various malignancies. Age appropriate cancer screening should be aggressively pursued in those with progressive CKD.
The role of SNAP and WIC participation and racialized legal status in U.S. farmworker health
Authors: Rockler Briana E. , Grutzmacher Stephanie K. , Garcia Jonathan , Smit Ellen
Published: August 2022

Background

Policies that restrict access to and use of the Supplemental Nutrition Assistance Program (SNAP) and Special Supplemental Nutrition Assistance Program for Women, Infants, and Children (WIC) by legal status may disproportionately disadvantage particular racial and ethnic groups. While immigrant legal status, race, and ethnicity are recognized as independent social determinants of health, studies examining the extent to which legal status structures racial and ethnic health disparities are limited. Research is needed to identify factors that mitigate disparate health outcomes, such as SNAP and WIC.

Methods

Cross-sectional data from the 2009/2010 National Agricultural Workers Survey (N = 3,961) were analyzed. Chi-square tests and logistic regressions examined associations among self-reported health, race, ethnicity, legal status, and SNAP/WIC participation.

Results

Farmworkers reporting excellent or good health were more likely to be non-Hispanic White, U.S. citizen, aged 18–25, single, male, educated beyond primary school, living above the poverty level, without chronic health conditions, and located in the Midwest. Hispanic farmworkers had lower odds of reporting excellent or good health (OR 0.27, 95% CI 0.12–0.62). Among SNAP/WIC participants, Hispanic farmworkers had higher odds of reporting excellent or good health (OR 6.74, 95% CI 1.54–29.57) compared to non-Hispanic White farmworkers. There was no significant association between self-reported health and legal status.

Discussion

This study complements the extant literature showing racial and ethnic health disparities among the U.S. farmworker population. Results provide valuable insight on the health-protective potential of programs like SNAP and WIC, particularly among Hispanic farmworkers, who may be both less likely to be eligible and more hesitant to participate. These findings underscore the need to expand U.S. farmworkers’ eligibility and participation in SNAP and WIC.
21. századi kompetenciák digitális technológiával támogatott fejlesztésének képessége
Authors: Horváth László , Baksa Lóránt , Csipke Ágnes , Gutai Lili , Szilágyi Dorka
Published: August 2022

Kutatásunk egy, a digitális transzformáció hatásait vizsgáló átfogó kutatás részeként, annak pilot projektjeként valósult meg. Vizsgálatunk során arra kerestük a választ, milyen összefüggésben áll a pedagógusok technológiai- pedagógiai-szaktárgyi tudása (TPACK) a pályán eltöltött éveik számával, a digitális eszközhasználat céljaival és azok mennyiségével, valamint a digitális eszközökkel támogatott oktatással kapcsolatos attitűdjeikkel. A pilot kutatás keretében kvantitatív kutatási stratégiát követve online kérdőíves vizsgálatot végeztünk pedagógusok körében annak érdekében, hogy az átfogó kutatás számára teszteljük a TPACK21 skála működését. A kérdőívben a TPACK21 mérésére a Valtonen és munkatársai (2017) által kialakított skála 21. századi kompetenciák fejlesztésére irányuló verzióját fordítottuk magyarra. A KIR adatbázis alapján az összes feladatellátási hely (régió és iskolatípus szerint rétegezve) véletlenszerűen kiválasztott 5%-ának juttattuk el a kérdőívünket. A tisztított adatbázisban 191 kitöltő szerepel. Az eredmények alapján nem igazolható, hogy a fiatalabb életkor magasabb TPACK21 értéket jelent. A digitális eszközhasználat céljait tekintve azonban szignifikáns összefüggés állapítható meg a TPACK21 érték és a célok mennyisége között: azok, akik magasabb TPACK21 pontszámmal rendelkeznek, többféle oktatási célra használják a digitális technológiákat, továbbá az átlag feletti TPACK21 értékkel rendelkezők csoportjában kimutathatóan magasabb arányban használnak digitális eszközöket az egyéni tanulási utak támogatására, Az eredmények megerősítik, hogy a TPACK21 skála képes a pedagógiailag tudatos eszközhasználat mérésére. Továbbá a vizsgálat alapján megerősítést nyert, hogy a bizonytalanság és a tehetetlenség érzete negatív mértékben befolyásolja a TPACK21 értékét, ami előtérbe helyezi a folyamatos szakmai fejlődés közösségi aspektusait (Phillips, 2017). Kutatásunk eredményei – bár önmagukban általánosítható következtetés levonására korlátozottan alkalmasak – hozzájárulhatnak a digitális transzformáció hatásait feltáró további kutatások sikerességéhez és további lehetőségek feltérképezéséhez.
CFTR deficiency causes PMCA4 dysfunction, intracellular Ca2+ elevation and promotes epithelial cell damage in alcoholic pancreatitis and hepatitis
Authors: Madácsy Tamara
Published: August 2022

Háttér és célok. Az alkoholos hasnyálmirigy- és májgyulladás gyakori, potenciálisan halálos kimenetelű betegség, korlátozott terápiás lehetőségekkel. Egy korábbi tanulmányunk arról számolt be, hogy a CFTR Cl- csatorna expresszióját az etanol károsítja a hasnyálmirigy duktális epitél sejtjeiben, ami súlyos alkohol-indukált pankreatítiszhez vezet. Az epiteliális ionszekréció meghatározásán túl a CFTR-nek számos kölcsönhatása van más fehérjékkel, amelyek befolyásolhatják az intracelluláris Ca2+ jelátvitelt. Ezért célul tűztük ki, hogy megvizsgáljuk az etanol által kiváltott CFTR-károsodás hatását az intracelluláris Ca2+ homeosztázisra a hasnyálmirigy duktális epitélsejtjeiben és cholangiocitákban. Módszerek. Humán és egér hasnyálmirigy- és máj mintákat, valamint ex vivo organoidokat használtunk az ionszekréció, az intracelluláris jelátvitel, valamint a fehérjék expressziójának és kölcsönhatásának vizsgálatára. A PMCA4 gátlás hatását az alkohol által kiváltott hasnyálmirigy-gyulladás egér modelljében elemeztük. Eredmények. A csökkent CFTR-expresszió károsította a PMCA működését, és tartós intracelluláris Ca2+ emelkedést eredményezett etanollal kezelt, valamint egér és humán hasnyálmirigy organoidokban. Az alkoholos hepatítiszes betegekből származó májminták és az etanollal kezelt egér máj organoidok csökkent CFTR-expressziót és -funkciót, valamint károsodott PMCA4-aktivitást mutattak. A PMCA4 kolokalizálódik és fizikai kölcsönhatásba lép a CFTR-rel a polarizált epitélsejtek apikális membránján, ahol a CFTR-függő kalmodulin rekrutáció határozza meg a PMCA4 aktivitását. A tartós intracelluláris Ca2+ emelkedés CFTR hiányában gátolta a mitokondriális funkciót és fokozott apoptózissal járt együtt a hasnyálmirigy epitélsejtekben, a PMCA4 gátlása pedig növelte az alkohol okozta AP súlyosságát egerekben. Következtetés. Eredményeink arra utalnak, hogy a Ca2+ -extrúzió javítása az epitélsejtekben potenciális új terápiás megközelítés lehet az exokrin hasnyálmirigy-funkció védelmére alkoholos pankreatítiszben és az alkoholos hepatítiszben kialakuló cholestasis megelőzésére.
Evolution of throat symptoms during the COVID-19 pandemic in the US
Authors: Nocini Riccardo , Henry Brandon M. , Mattiuzzi Camilla , Lippi Giuseppe
Published: August 2022

Objectives

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) structure and host tropism have changed over time, and so has the involvement of throat structures. This infodemiological analysis is hence aimed at investigating the evolution of throat symptoms during the COVID-19 pandemic in the US.

Methods

We searched Google Trends using the medical search terms “ageusia”, “hoarseness”, “dysphonia”, “pharyngitis” and “laryngitis”, setting geographical location to “United States”, within the past 5 years. The weekly Google Trends score for these symptoms, which reflects their national Web popularity, was divided in three parts, as “pre-COVID” (July 2017 to February 2020), COVID-19 “pre-Omicron” (March 2020 to November 2021), and COVID-19 “Omicron” (December 2021 to July 2022), and then compared.

Results

The volume of searches for ageusia increased in the pre-Omicron period and remained significantly higher also during Omicron prevalence, though a significant decrease (∼30%) occurred with Omicron lineages compared to previous strains. The Google searches for hoarseness and dysphonia were relatively similar between the pre-COVID and pre-Omicron periods, but then significantly increased during Omicron predominance. The Google searches for pharyngitis and laryngitis decreased in the pre-Omicron period, but then considerably increased following Omicron emergence. Omicron endemic spread could be significantly and independently predicted by the volume of searches for pharyngitis, laryngitis and hoarseness.

Conclusions

The epidemiological burden of throat symptoms has considerably changed after Omicron emergence, with a lower likelihood of developing chemosensory dysfunctions and enhanced risk of throat involvement.
Dynamics of the translocation pore of the human peroxisomal protein import machinery
Authors: Ghosh Mausumi , Denkert Niels , Reuter Maren , Klümper Jessica , Reglinski Katharina , Peschel Rebecca , Schliebs Wolfgang , Erdmann Ralf , Meinecke Michael
Published: August 2022

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and imported in a posttranslational manner. Intricate protein import machineries have evolved that catalyze the different stages of translocation. In humans, PEX5L was found to be an essential component of the peroxisomal translocon. PEX5L is the main receptor for substrate proteins carrying a peroxisomal targeting signal (PTS). Substrates are bound by soluble PEX5L in the cytosol after which the cargo-receptor complex is recruited to peroxisomal membranes. Here, PEX5L interacts with the docking protein PEX14 and becomes part of an integral membrane protein complex that facilitates substrate translocation into the peroxisomal lumen in a still unknown process. In this study, we show that PEX5L containing complexes purified from human peroxisomal membranes constitute water-filled pores when reconstituted into planar-lipid membranes. Channel characteristics were highly dynamic in terms of conductance states, selectivity and voltage- and substrate-sensitivity. Our results show that a PEX5L associated pore exists in human peroxisomes, which can be activated by receptor-cargo complexes.
Abelian sharing, common informations, and linear rank inequalities
Authors: Mejia Carolina , Montoya Juan Andres
Published: August 2022

Dougherty et al. introduced the common information (CI) method as a method to produce non-Shannon inequalities satisfied by linear random variables, which are called linear rank inequalities. This method is based on the fact that linear random variables have CI. Dougerthy et al. asked whether this method is complete, in the sense that it can be used to produce all linear rank inequalities. We study this question, and we attack it using the theory of secret sharing schemes. To this end, we introduce the notions of Abelian secret sharing scheme and Abelian capacity. We prove that: If there exists an access structure whose Abelian capacity is smaller than its linear capacity, then the CI method is not complete. We investigate the existence of such an access structure.
Jewish Forerunners of the SpanishBiblia romanceada: A Thirteenth-Century Witness (Bodleian MS Hunt. 268)
Authors: Lawrance Jeremy
Published: August 2022

Despite Church prohibitions, almost twenty medieval Bibles in Spanish survive. The Old Testament versions derived in many cases from translations from Hebrew made by Jews. These were characterized by a unique rabbinical “calque-language” that would be preserved by Sephardim for centuries after the Expulsion in 1492; but the Inquisition destroyed the medieval Jewish copies. This article studies a new witness, the oldest known: a thirteenth-century Hebrew commentary on the Hagiographa with Spanish glosses. These fully confirm the amazing continuity of the Ladino scriptolect.
La rivalidad entre -cióny-mientoen el romance castellano-aragonés del siglo XV: una aproximación a la morfología léxica desde la dialectología histórica
Authors: Raab Matthias
Published: August 2022

This research aims to analyze a hypothetical higher profitability of ‑mientoin the interior Romania, compared to the preference for the derivative ‑ciónin the exterior Romania. Therefore, the analysis is based on a thousand words ending on ‑ciónand ‑mientothat appear in theDiccionario del castellano del siglo XV en la Corona de Aragón(DICCA-XV), since its texts represent specific linguistic features that are between the western and eastern variety – referring to the Iberian Romance group –​ and, at the same time, between interior and exterior Romance languages. The research’s goal is multifactorial and takes into account historical-etymological, morphological, semantic, syntactic questions and the textual typologies in which the different elements usually appear and aims to investigate both the operation of words without morphological doublet and those units that do compete with some morphological variant.
Az egészséges táplálkozás szubjektív megítélése az egyetemisták online és offline információkereső magatartását illetően
Authors: Fehér András , Kovács Bence , Boros Henrietta Mónika , Szakály Zoltán
Published: August 2022

A TANULMÁNY CÉLJA

A fiatal korosztályok képviselői a saját egészségük megőrzése mellett információközvetítő szerepet is betölthetnek a társadalomban. Az egyetemista évek során kialakult táplálkozási szokások hatással vannak az egész életen át tartó életmód megalapozására. A kutatás során a fő célkitűzésünknek megfelelően egy koncepcionális modell által azonosítottuk az egyetemi hallgatók egészséges táplálkozással kapcsolatos online és offline információkereső magatartását.

ALKALMAZOTT MÓDSZERTAN

A primer kutatás során önkitöltős papíralapú kérdőívet juttattunk el országosan tíz egyetemre.  A célcsoportunk egyetemi hallgatók voltak. A mintánk 612 főből állt. Az elemzés során gyakoriságvizsgálatot, Khi-négyzet próbát, Mann–Whitney- és Kruskal–Wallis-próbát alkalmaztunk, illetve leíró statisztikákat számoltunk. Az összefüggésvizsgálatban az egészséges táplálkozás szubjektív megítélésének változóit vettük figyelembe. Az információkeresés jellegét az internet információkereső modelljével (ISM), az egészséges táplálkozásra való áttérést a változás transzteoretikus modelljével elemeztük (TTM). A modell minden egyes elemét korábbi kutatások alapján határoztuk meg, bizonyos esetekben adaptáltunk a saját kutatási céljainknak megfelelően. A tanulmányban meghatároztuk a 6 elemből álló online és a 14 elemből álló offline információforrás-kategóriákat, amelyekre a modell összefüggésvizsgálatait építettük.

LEGFONTOSABB EREDMÉNYEK

Megállapítható, hogy az online és az offline információforrások végigkísérik az egyetemisták egészséges táplálkozásra történő áttérését, emellett differenciálhatók a viselkedésváltozás egyes szakaszainak sajátosságai az információszerzés esetében. Az offline források leginkább a kezdeti szakaszokban („bezárkózás” és „szemlélődés”) fontosak, míg az online források a „fenntartás” fázisában jelentősebbek.

GYAKORLATI JAVASLATOK

Az egyetemista korosztály egészséges táplálkozással kapcsolatos információszerzését komplex módon elemeztük, így egy saját megközelítés összefüggéseit kaptuk meg az elemzéseink során. Lényeges megállapítani, hogy a modell nem csak az egyetemi hallgatók, hanem más célcsoportok magatartásának mérésére is releváns lehet.

Köszönetnyilvánítás: A tudományos közlemény elkészítését az EFOP-3.6.1-16-2016-00022 számú projekt támogatta. A projekt az Európai Unió támogatásával, az Európai Szociális Alap társfinanszírozásával valósult meg.
For everything there is a season: more than a year of destruction at Seleucid Tell Iẓṭabba (Israel)
Authors: Lichtenberger Achim , Mienis Henk , Orendi Andrea , Pines Miriam , Rittner Oz , Tal Oren
Published: August 2022

The Seleucid town of Nysa-Scythopolis on Tell Iẓṭabba (Israel) was destroyed by the Hasmoneans at the end of the second century BC. In this article, we discuss the exact season and possible year of the destruction using a multimodal approach and argue for its destruction in spring/early summer 107 BC.
Role of uterine biophysical profile in predicting conception in a sample of infertile women attending an IVF center in Erbil
Authors: Sedeq Medya
Published: August 2022

Background and objective: Failure to get pregnant can be profoundly disappointing, frustrating and eventually lead to a lot of social, medical, and psychological consequences like depression. This study aimed to evaluate the role of uterine biophysical profile in predicting conception in women with a history of infertility. Methods: A prospective diagnostic accuracy study was conducted in Erbil, Iraqi Kurdistan region, in the Maternity Teaching Hospital from October 2019 to September 2020 on 51 women suffering from primary and secondary infertility. Vaginal ultrasound was performed for all the women at mid-cycle and before embryo transfer. The uterine scoring system for reproduction by Applebaum was calculated, and the total score was obtained. Its role in predicting conception was determined. Results: A cut-off of 15 scores of the uterine scoring system for reproduction gave a sensitivity of 86.7% and a specificity of 100%. Factors found to be associated with high rates of pregnancy were endometrial thickness 10-14 mm (P <0.001), distinct trilaminar layer (P <0.001), abundant blood flow within zone 3 (P <0.001), and uterine artery Doppler PI of <2.19 (P <0.001). The last two parameters gave a pregnancy rate of 100%. Conclusion: Applebaum’s uterine scoring system for reproduction is an easy, simple, noninvasive method for predicting pregnancy in women suffering from primary and secondary infertility. Both uterine artery Doppler PI and endometrial receptivity (including thickness, character, and vascularity) are two important parameters in predicting suitable environment for implantation and pregnancy outcome. Keywords: Uterine scoring system for reproduction (USSR); Uterine biophysical profile; In-vitro fertilization (IVF); Intrauterine insemination.
Cultural and confessional factors of psychological differences in adaptive and preadaptive meaning-related regulation
Authors: Abakumova Irina , Godunov Mikhail
Published: August 2022

The relevance of studying the features of the meaning regulation of a person is due to the need to describe the mechanisms of the formation of meanings under the influence of cultural, social, historical and ideological aspects of his life. The authors present a theoretical analysis of the features of the formation of the system of personal meanings of people belonging to Western and Eastern Christianity. The purpose of the article is to identify the cultural and confessional factors of psychological differences in adaptive and preadaptive meaning regulation that exist among representatives of the Catholic and Orthodox branches of the Christian world. The paper analyzes the influence of various cultural and confessional factors on the meaning regulation of representatives of Catholicism and Orthodoxy. Catholicism and Orthodoxy, as the western and eastern branches of Christianity, have corresponding differences in the field of religious priorities: God's descent to earth at Christmas and likening to man against the divine Resurrection as a sacrifice for man; worldview: anthropocentrism against сhristocentrism; epistemological views: logical analysis and materialistic rationalism of the intellect and against the sacred unity of the relationship between man and nature; value attitudes: acceptance of one's imperfection against the desire for a divine prototype; cultural priorities: welfare versus sanctity; ethical beliefs: primacy of individual rights versus duties to the soul's conscience; social identities: self-affirmation based on law versus religious humility before spiritual precepts; political preferences: individual freedom versus the common good; legal concepts: legal contract versus moral union. Based on the analysis of the scientific works presented in this study, it is proposed to consider the cultural and confessional features of Catholicism as correlating mainly with the adaptive orientation of meaning-forming strategies, and Orthodoxy as correlating mainly with the preadaptive orientation of meaning-forming strategies.
Modernization of domestic education as a historically determined process
Authors: Milovanov Konstantin
Published: August 2022

This article is devoted to the problem of studying the methodology and strategies of modernization of education in the Russian socio-cultural tradition. The modernization process currently underway in the national education system of Russia and domestic pedagogical science actualizes the need to analyze educational transformations over the past century. This circumstance is of extremely important fundamental and scientific and practical importance for the development of strategic parameters for the comprehensive modernization of the modern national education system. The methodological significance of the study lies in the urgent need for a projective-analytical reconstruction of the multidimensional process of development of promising strategies for modernization and reform of education. The chronological and analytical correlation of the evolution of Russian studies of educational systems at this historical stage within the dynamics of socio-cultural development is essential here. It also seems timely to study the pedagogical dimensions of the development of the national education system based on the study of the contribution of leading Russian scientists to the understanding of modernization processes. This will allow to harmonize and integrate various research models of the national pedagogical tradition, which will contribute to the development of the theory and practice of the functioning of educational systems. The applied significance of the research is connected with the urgent tasks of rethinking the existing experience of the strategic development of national education systems. A certain research interest is the process of scientific, methodological and analytical support for the formation of mechanisms for the introduction of strategic models of modernization and concepts of reforming modern domestic education. This research will contribute to the accumulation of knowledge about the current state and development of the complex of sciences of education and their role in the process of modernization and reform of Russian education. It will also make it possible, in the conditions of increasing globalization, to scientifically design promising and futurologically meaningful models of strategic development and management practices in the national education system.
Distant technology in theological education: methodological foundations of “classical” distance learning and possibilities of remote support for full-time courses with the example of the discipline “Typicon and hymnography” of the theological professional retraining programme
Authors: Nikulina Elena
Published: August 2022

The article analyses and compares methods of teaching theological disciplines using distant technologies on the Faculty of Advanced Further Education and in the Institute of Distance Learning at St. Tikhon’s Orthodox University, as well as the experience of transferring full-time education to distance learning in spring of 2020 using the example of the discipline “Typicon and Hymnography” taught at the Theological professional retraining programme. It is shown that the transfer of the full-time course “Typicon and Hymnography” to distance learning encouraged the methodological convergence of two forms of education (full-time and part-time with the usage of distant educational technology) and at the same time identifi ed distinctive features of each of them. Full-time course was enriched by the inclusion of the distance learning technology tools with technical means, which added methodological orderliness. Moodle platform’s technical facilities allowed the teachers to keep practical orientation of the course (theory combined with the experience of attending church services) and integration of full-time course into the church calendar. The article also examines methodological opportunities of both forms of education, in context of an educative (that brings a person to church) mode of the course in Typicon and Hymnography. The article also describes features that form the communication between the teacher and students in full-time and in part-time education using distant educational technologies at the Institute of Distance Learning of St. Tikhon’s Orthodox University.
Patriotic education of children in sunday schools and the use of fine arts materials
Authors: Borodina Elena
Published: August 2022

In the first part of the article, the author reveals the theoretical substantiation of the problem: aspects of the patriotism of an Orthodox Christian as a virtue, a spiritual and moral quality. The phenomenon of patriotism is presented in the context of the works of the Church Fathers of the 19th and 20th centuries and the main provisions of the social concept of the Russian Orthodox Church; the canon of the Orthodox view on the problem posed is adhered to in substantiation. For an objective understanding of the semantic essence of the concept of patriotism, the author turned to scientific literature, explanatory and encyclopedic dictionaries, philosophical and pedagogical works of compatriots. Having analyzed a number of scientific points of view, the author states about the spirituality and religiosity of patriotism, highlighting the semantic connection with morality. In the second part of the article, the author examines the effectiveness of the use of paintings of battle, historical, portrait and everyday life in the process of patriotic education in Sunday school. The article reveals the content and characteristics of problem-value communication, describes the stages of the methodology based on problem-value communication in the process of cognitive conversation based on the painting of patriotic themes: the first stage is cognitive (the contradictions between acceptance and rejection, admiration and indifference are resolved); the second stage is evaluative-semantic (evaluative-semantic activity is carried out - the correlation of new ideas, concepts, values, with already existing and previously acquired knowledge and value attitudes and beliefs); the third stage is motivational and activity (the child appropriates a personal spiritual and moral meaning, in which the basic national value - patriotism, becomes valuable and significant, a regulator of the patriotic mentality, a motive for action). The author reveals the potential of the methods of art pedagogy: “the method of unity of perception and creation in artistic action”, “the method of getting used to it” or “the method of revitalization”, describing the process of emotional and sensory empathy with the main characters of paintings.
Concerts of spritial music in the russian province in the early 20th century (with towns of the Middle and Lower Volga region)
Authors: Polozova Irina , Tyuryakova Juliya
Published: August 2022

The article examines some aspects of the musical and educational activities carried out at the turn of the XIX-XX centuries. provincial church-singing communities of various Christian denominations. As an example, the cities of Saratov, Samara, Simbirsk and Syzran are covered - the largest economic and cultural centers of the Middle and Lower Volga regions. The authors analyze the concert activity of the represented provinces in several directions: concerts of pra-glorious liturgical chants, spiritual concerts with mixed programs, concerts of sacred music in Catholic and Protestant churches, and also separately highlight examples of the premiere performance of author's spiritual works in provincial temples. Thus, the work highlights the educational concert and educational work of the professor of the Saratov Conservatory I.V. Lipaev, the Saratov Bishops' Choir under the direction of N.M. Dmitriev, Simbirsk Bishop's Choir (choir director S.P. Yagodinsky). The authors provide examples of touring performances by leading choral groups of the Russian Empire in the Volga cities, in particular, the Moscow Synodal Choir (conducted by N.N. Tolstyakov) in Saratov and the choir of the St. Samara. In addition, the article touches on the problem of interaction between Orthodox and co-religion communities, the performance of joint services by them (possible within the framework of the same-faith Liturgical practice), as well as the preservation of the Volga region of a living tradition of using the znamenny chant. As a result of the research carried out, the article traces the idea of the continuity of the ideas of the New direction in Russian sacred music by the Volga choir directors, as well as the active inclusion of the latter in the general process of development of Russian church singing art.
Bishop’s choir of Astrakhan in concerts of sacred music
Authors: Chervyakova Irina
Published: August 2022

In the post-Soviet period, there was a noticeable increase in interest in the church singing art. Professional musicians were given the opportunity to perform and study music that had not been so widely distributed until that time. For many, another direction for self-realization has opened up. Spiritual music has increasingly begun to go beyond the scope of worship and is performed everywhere by both secular and church choirs on the stage. Thus, this kind of the richest Russian cultural heritage became more accessible not only for the parishioners of churches, but also for the listeners of concert halls.Traditions of concerts of Orthodox music, with the joint performance of church and secular choirs have been laid in Astrakhan since the early 1990s. The organization of such events is one of the directions of concert and educational activities of the Astrakhan Metropolis. The Astrakhan Bishops' Choir has always been an indispensable participant in these concerts. He is in many ways a model for other singing groups of the city, such a format of activity has a great influence on the professional state of choir choirs, repertoire preferences, manner of performance and much more.In this article we will consider the concert style of singing of large cathedrals on the example of the bishops' choir of the Intercession and Assumption cathedrals, their concert and festival activities.
Paired compositions "Birth of Christ" and "Death of Theotokos" on monumental painting of the Cathedral of Nativity of Theotokos in Savvino-Storozhevsky monastery (1649–1650): the role in the programme and features of iconography
Authors: Gribkova Anna
Published: August 2022

The article is devoted to the origins of the appearance of paired compositions The Birth of Christ and The Death of the Virgin on monumental painting of the Nativity of the Virgin Church in Savvino-Storozhevsky Monastery 1649–1650. The tradition of reproducing ancient programs that developed in the second quarter – the middle of the 17th century makes it possible to attribute the monastery cathedral in Zvenigorod to this practice. The presence of large paired compositions in naos find similarities with Russian monuments of the 12–16th century, rather than with paintings of their time. Both compositions are in harmony with The Birth of the Virgin on the western wall and The Praise of the Virgin in the central conch. The combination of four scenes reveals the main meaning of the entire program, which consists in the idea of the glorification of the Virgin. The scenes of the Life of the Virgin, located on the eastern wall of the naos, testify to their presence here even before the construction of the iconostasis of the 17th century. Meanwhile, the iconographic analysis of paired compositions brings them closer to the monuments of their time. Firstly, it is noticeable in the composition The Birth of Christ which is structurally close to the multipart icons of the 16–17th centuries. In the scene The Death of the Virgin there is a similarity with the temple icon from the Assumption Cathedral of the Moscow Kremlin of 1472–1474, and a veil embroidered for her in the 1640s. The results of the study show that paired compositions could be part of the old painting, while in the middle of the 17th century they, along with the entire program, were updated and supplemented with new elements.
The Space of the Word: epigraphy in the interiors of Dutch churches of the 17th century
Authors: Tyupanova Oksana
Published: August 2022

The article deals with the problem of the relationships between the word and the image in the monuments of pictorial and graphic art, depicting the text, so-called text painting, «tekstschilderijen» in Dutch. Mostly anonymous, these monumental images of the Word were painted on boards, columns, and church walls throughout the Northern Netherlands during the first century after the Reformation. Formally, these images belong to the history of painting, since the same materials are used: paints on a board or on a stone in a decorative frame, but the way of depicting reminiscent of an enlarged page of Holy Scripture puts them on a par with the monuments of graphic art. The emergence of “verbal pictures”, texts that became ornaments and calligraphy, the scale and structure of which shifted their verbal content from the individual world of personal initiation into the fixed didactics of public space, corresponded to new doctrinal guidelines and radically changed the semantic structure of the Gothic cathedral. The Bible provided a new graphic language: text that was authoritative enough to become canonical and flexible at the same time to take many varieties of forms. “Verbal pictures” were the texts that became ornaments and calligraphy. The dialectical content unity, their design, interaction with the church space and viewing traditions of the text pictures help to reconstruct not only the author's intention as artistic ones, but also the cultural and historical context.
Restauradores y bicentenarios: los discursos alegóricos de la campaña electoral costarricense 2018
Authors: Carballo Chaves Pablo
Published: August 2022

Las elecciones del 2018 en Costa Rica dejaron ver una versión discursiva que parecía improbable. Durante la segunda ronda de las elecciones donde se disputaron la presidencia el Partido Acción Ciudadana (PAC) liderado por Carlos Alvarado y el partido Restauración Nacional (RN) con el candidato Fabricio Alvarado, se mostró una dialéctica discursiva en la cual, por un lado, se indica la tradición socialdemócrata, esperable –aunque cuestionada–, pero, por otro lado, y de modo preocupante, la posición del fundamentalismo religioso. De esta dualidad  discursiva, se analiza comparativamente dichos mensajes a partir de contrastar lo “asumido” y lo “asignado” en función del uso alegórico de los dos partidos políticos en pugna electoral, concentrándonos en la propuesta del partido RN.
Representaciones visuales del acoso laboral en internet
Authors: Mac Donald Quiceno Jessica , Mac Donald Quiceno Jessica
Published: August 2022

Se realiza un análisis iconológico de imágenes que circulan en internet para explorar  las representaciones visuales construidas sobre el acoso laboral. La captura de las imágenes se realizó en dos momentos a través del buscador Google Imágenes, en los meses de noviembre y diciembre del 2018 y en enero del 2021. Se contrasta la literatura sobre este fenómeno, con la caracterización de las imágenes encontradas en la red, las figuras retóricas utilizadas, las interacciones y los contextos que se posicionan en ellas, los elementos visibilizados e invisibilizados sobre el acoso laboral, y los principios socioculturales que expresan estas imágenes.
Application analysis of time stepping methods for impact problems
Authors: Serfőző Dániel , Pere Balázs
Published: August 2022

Dynamic contact and impact problems are widely applicable. An accurate solution method for these kinds of problems can be used in many fields of mechanical engineering (e.g., cutting metalwork, cogwheel drives, etc.). However, the proper handling of the contact is problematic, as there emerges a substantial amount of nonlinearity in the displacement field. Therefore, a spurious high frequency oscillation is present in the solution. These oscillations must be avoided, as divergence can easily occur in the contact algorithm due to them. In order to eliminate this effect, the applied numerical method must be chosen and set properly. In this study, a comprehensive guide is provided for the appropriate selection of the proper numerical method and its parameters.
Trematode larval infections in snails collected from aquaculture ponds in Ha Noi and Yen Bai, Vietnam
Authors: Manh Hung Nguyen
Published: August 2022

The hot-spots of transmission of food-borne zoonotic trematodes in northern Vietnam have been known as the integrated fish-livestock (VAC- Garden, Fish pond, Poultry shed) ponds. A cross-sectional study was conducted in Ha Noi capital and Yen Bai province to investigate the trematode larval infections (cercariae) in freshwater snails in these areas. Snails were collected from 35 VAC ponds, including 25 grow-out and 10 nursery ponds. A total of 13,895 specimens of 12 snail species were examined for cercariae shedding. Six of 12 snail species including Melanoides tuberculata, Tarebia granifera, Radix auriculata, Gyraulus convexiusculus, Bithynia fuchsiana and Parafosarulus manchouricus, shed cercariae. Seven cercarial types were detected. The amount of snails and the prevalent infection in nursery ponds were 1.14 and 1.3 times higher than in grow-out ponds, respectively. Thus, VAC ponds in northern Vietnam are still the hot-spot for trematode larval infection.
Detection of c.G2194A mutation in \(\textit{AR}\) gene of a vietnamese patient with androgen insensitivity syndrome: a case report
Authors: Nguyen Thu Hien , Nguyen Thi Kim Lien , Nguyen Huy Hoang , Nguyen Thi Thanh Ngan , Tran Thi Huong Giang , Nhung Nguyen Hong , Phuong Mai Nguyen Thi , Hoang Nguyen Huy
Published: August 2022

Androgen insensitivity syndrome (AIS) is a rare X-linked recessive androgen receptor (AR) disorder. However, the overlap in clinical manifestations between AIS and other disorders of sex development can cause clinical diagnostic difficulties. Applying the whole coding region sequencing method is an optimal method for the diagnosis of AIS. In this study, whole-exome sequencing was performed to screen mutations in the AR gene as well as genes related to disorders of sex development (DSD). Sanger sequencing was applied to validate the mutations in the patient. One missense mutation in the AR gene which was reported previously was identified in the patient. In this site, nucleotide G is changed to A at position 2194 on cDNA (c.G2194A), leading to a substitution of aspartic at position 732 aspartic to asparagine (p.Asp732Asn). However, this is the first published case in a Vietnamese with this mutation. Our study expands the mutation spectrum of the AR gene in Vietnamese patients and confirms the usefulness of whole-exome sequencing in the diagnosis of AIS. The results of the study are the basis for supporting doctors in prenatal diagnosis and giving reasonable advice to patients and families.
Influence of exogenous application of melatonin on biochemical changes of avocado fruit during ripening
Authors: Cam Tu Vu Thi , Thanh Tra Huynh Thi , Duc An Hoang , Duy Thanh Le , Hoang Thi Minh Nguyet , Thi Hue Truong
Published: August 2022

Melatonin (MT) is considered as a plant growth regulator, has extensive functions and plays a prominent role in ripening and fruit senescence. However, there has been no report regarding the influence of melatonin on biochemical changes of avocado fruit (Persea americana Mill.) during ripening. In this study, the cultivar of avocado fruit “034” was treated with MT at 0.1 mM and 0.5 mM to evaluate biochemical changes relating to the fruit quality during storage at 22 oC ± 1 and 75–80% relative humidity. The results showed that postharvest fruits treated with MT effectively delayed the changes in ripening parameters and that the effectiveness depends on MT concentration. Application of MT (0.5 mM, immersion for 2 hours) to “034” avocado enhanced total phenol and flavonoid accumulation and maintained titratable acidity, total soluble solids, lipid and ascorbic acid contents. Furthermore, 0.5 mM MT treatment effectively suppressed the increase of total sugar and reduced weight loss compared with the control fruit after 12 days of storage. The results indicate that the MT application could be a useful tool to maintain avocado fruit quality during the postharvest stage.
Effects of simulated microgravity on senescent human fibroblasts
Authors: Ngoc Cang Ly , Quang Huy Hoang Nghia , Nghia Son Hoang , Thanh Long Le
Published: August 2022

This study aimed to assess the effects of simulated microgravity (SMG) on senescent human fibroblasts (HFs). The HFs were treated with 150 µM H2O2 in a culture medium for 90 minutes for senescent induction. The senescent HFs were induced SMG for 72 hours by a Gravity simulator, while the control group was treated in the same CO2 incubator. Cell morphology analysis showed that the SMG condition retrieved the fibroblastic morphology from the senescence. WST1 assay and cell counting indicated that the senescent HFs viability from the SMG group was higher than the control group (OD value of 0.80 ± 0.13 vs. 0.64 ± 0.11, respectively). In cell cycle progression, the G0/G1 cell percentage of senescent HFs from the SMG group was reduced, compared to the control group (45.84 ± 1.37% vs. 57.22 ± 1.56%, respectively). The senescent HFs from the SMG group exhibited a lower nuclear area than the control group (186 ± 4 µm2 vs. 217 ± 8 µm2, respectively). This resulted in the performance of a higher nuclear shape value of senescent HFs from SMG, compared to the control group (0.74 ± 0.02 vs. 0.70 ± 0.01, respectively). SMG condition caused the down-regulation of the senescence-related transcript. These results found that SMG could regain the normal characteristics of HFs from the senescence.