bluuebunny/crossref_metadata_2025 huggingface dataset:
Drug Function Testing Will Benefit from the Miniecosystems Designed by Chemists v1
Authors: Smith Bella
Published: June 2018

It is reported that scientists from Scripps Research have worked a way out to solve the a major problem in chemistry and drug development. They designed a miniecosystems to see if a molecule has the function of a potential therapeutic. This research result has been reported on the journal—Proceedings of the National Academy, and it is learned that this technology allows researchers to save critical time and funding by simultaneously testing how drug candidates bind to their cellular targets and alter cell function. Tianqing Zheng, Ph.D., postdoctoral associate on Scripps Research's California campus, said that this could save a lot of time in drug discovery by reducing the steps needed to assess drug candidates, and co-cultivation of mammalian and bacteria cells in mini-ecosystems makes it possible to select functional antibodies directly with antibody phage display. What’s more, he added that antibody phage technology has propelled the development of pharmaceuticals and the next step is to apply this method to select functional antibodies against many more targets of interest as of the success of this method. This study shows that the miniecosystem is testing for affinity and function at the same time. The miniecosystems are held in droplets the size of a picoliter—or one-trillionth of a liter. In these cramped quarters, the researchers brought together a mammalian cell and E. coli bacteria. The mammalian cell in the droplet is engineered to express a fluorescent protein if properly targeted by an antibody. This symbolizes that researchers can detect antibody affinity and function more time- and cost-effectively. In order to test their new system, the researchers quickly generated millions of miniecosystems with mammalian cells and bacteria that produce magic phage-tethered antibodies. They tested these antibodies against a real biological target: a receptor on brain cells, called TrkB, which revealed that antibodies are functioning as a therapeutic at targeting TrkB when attached to phage, rather than the antibody alone which they had proved in previous studies. The miniecosystem should be a milestone in the drug function research field. Although scientists faced a bottleneck, they finally worked it out and proved that this study is successful in testing drug function.
Thymus dissociation v2
Authors: Potter Andrew
Published: June 2018

Protocol for thymus dissociation (10-week old CD-1 female).
Adult Mouse Spleen Dissociation (On ice) v2
Authors: Potter Andrew
Published: June 2018

Protocol used to dissociate adult (8-10 wk) mouse spleen into single cells. Attained >95% viability, a variety of cell sizes, and ~10 million cells from 12 mg tissue.
INSTRUÇÕES PARA A ELABORAÇÃO DOS RELATÓRIOS DE PORTFÓLIO PESSOAL
Authors: Natario Pedro
Published: June 2018

Este texto pretende fornecer instruções aos alunos sobre a elaboração dos Relatórios relativos às actividades extra-curriculares desenvolvidas no quadro dos Portfólios Pessoais, dando ao mesmo tempo um template que pode ser usado e adaptado pelos alunos. Este texto não substitui o “Regulamento dos Portfólios” que todos os alunos devem já ter lido.
Psychological components of decision-making in mentally ill persons
Authors: Shekhovtsova E.S. , Dubinsky A.A.
Published: June 2018

The article is devoted to the study of individual psychological characteristics of decision-making in persons with mental pathology. The material of the empirical study of 99 men (mean age = 34.1 ± 10.6 years) with the following psychiatric diagnoses: organic mental disorders (F07) (OMD), schizophrenia and schizotypic disorder (F20, F21), personality and behavior disorders (F60, F61). The methodological complex included: "Verbal and color interference" tests by J. Stroop and "Comparison of similar drawings" by J. Kagan, questionnaires "Style of self-regulation of behavior" V.I. Morosanova and New Questionnaire of Tolerance to Uncertainty Kornilovoy, semiprojective methods "Identification of the awareness of motives" А.V. Ermolina and B.P. Ilyin and "Situational analysis" (Bulygina VG, 2017). It was revealed that the parameters of "tolerance to uncertainty", "assessment of conditions", "cognitive rigidity", "drives" and "evaluation of results" have the greatest nosocertainty. Within the context of the situational analysis, the influence of the amount of information available, the level of its uncertainty and emotional saturation on the adequacy of the interpretation of the situation, the number and adequacy of the proposed alternatives, and the social acceptability of the answers was established.
Aggressiveness of middle and high school students and their preferred styles of behavior in conflict situations, gender aspect
Authors: Shamlikashvili T.A. , Haritonov S.V. , Pchelinceva D.N. , Grafsky V.P.
Published: June 2018

The paper presents the results of a study of the propensity of students of the state budgetary educational institution to manifestations of various forms of aggression and their preferred strategies of behavior in conflict situations.
The study was conducted on the basis of one of the state budgetary institutions of Moscow and included data from 462 children aged 11 to 17 years.
It is defined that in dynamics from middle to senior classes at girls the tendency to manifestation of indirect aggression, offense and verbal aggression increases, at boys the tendency to physical, indirect and verbal aggression and offense increases. The severity of these forms of aggression is at levels — above average.
In high and middle school students, the strategy of rivalry is not the preferred choice of behavior in conflict, but rather compromise and avoidance in high school and adaptation and avoidance in middle school.
Thus, conflict tensions in educational institutions are not associated with the level of aggressiveness of secondary and higher school students. It is obvious that there are other mechanisms that remain insufficiently studied.
Danced Out: When Passing For Almost Straight Is Not Enough
Authors: Broomfield Mark
Published: June 2018

No abstract available.
Narrative Shifts: Race, Culture, and the Production of Screendance
Authors: White Marcus R
Published: June 2018

Moving 24fps is a platform where teams of one professional dance maker and one filmmaker are paired to create work in a single weekend. These ‘creatives’ make work as a part of the touring Festival: It focuses exclusively on the production of screendance and is situated within various ‘partner cities’. This article is informed by a collection of both informal and open forum interviews with over 25 creatives about their experience inside the project. We were curious how screendance can be used as a tool to help shape and reimagine each cities narrative as it relates to identity politics and what it could reveal about a national discourse of race and culture within the production of screendance. For the purposes of this journal, individual dance shorts from the Moving 24fps Detroit project will be used as case studies to examine the creative process and to investigate representation, equity, and inclusion in screendance curation and production.Two questions that frame this entire paper: What considerations and choices do creatives make to center race and geo-politics within their city?  How does the project create or promote equity in dance film curation?
Bodies in Confined Sites, or, 'When You Go Out, Let Them Know That We Are Not Monsters'
Authors: Mikou Ariadne
Published: June 2018

No abstract available.
IJSD Volume 9 2018 Screening the Skin: Issues of Race and Nation in Screendance Full Issue
Authors: Blanco Borelli Melissa , Monroe Raquel , Bench Harmony , Ellis Simon
Published: June 2018

No abstract available.
HOLONIC APPROACH TO CONTROL INTELLECTUAL DEVELOPING LEARNERS
Authors:   Samara State Social and Pedagogical University, Samoilov E.
Published: June 2018

Analysis of the features of modern society, trends in the development of educational systems, state general secondary and higher education in Russia, as well as the results of ascertaining experiment reveal the complex contradictions: between the new identity requirements of the family, the state, the vocational training system to the quality of individual intellectual development and the level research control intellectual development of students; between the need for an individual approach to the development of a unique and intellectual identity of each student in a group and the absence of the indicative range of relevant fundamentals, teaching tools, designing and organizational skills of many teachers; between the broad didactic possibilities of modern training equipment, technical training and the lack of adequate teaching materials that provide system control intellectual development of students (CIDS) with a high level of assimilation of the academic content. These contradictions determine the relevance and the need to create modern intelligent control concept of the development of learners, adequate characteristics of the information society. This article describes holonic approach to solving this problem, according to which organizational system does not provide for the separation of managing and managed subsystems. Delegation is the leadership part of the administrative functions to ordinary employees is necessary in the management of diversity and the possibility of "obtaining reliable results from unreliable components", which in the end, and provides the educational organization as macro holon and its individual members, the sustainability and survival in a changing world.
ONTOLOGY-DRIVEN APPROACH TO MEDICAL DATA FUSION
Authors:   Saint Petersburg Electrotechnical University ", Lebedev S. ,   LETI", Zhukova N. ,   ITMO University
Published: June 2018

A large volume of operational and statistical data has been stored within medical information system databases. The stored data represents a loosely-coupled and semi-structured clump. To increase information support of medical procedures it is necessary to implement data linking processes into the medical information systems. The aforementioned processes should be able to collect data from diverse sources and produce a linked view that can be used for medical evaluation, planning, etc. To solve this problem, an approach based on JDL (Joint Directors of Laboratories) data fusion model and ontologies is presented. JDL model defines functional levels of data fusion and their interconnections. Ontologies are used to set links between data and knowledge. To specify and evaluate the proposed approach, a simplified scenario is constructed. The scenario was prepared for the Federal Almazov North-West Medical Research Center. The proposed scenario includes the following actions: extraction of a list of drugs and diagnosis from semi-structured data; annotation of extracted data using author's ontology and third-party ontologies; revealing interacting drugs that are prescribed to a patient; data representation. The scenario shows that ontology-driven data fusion approach has a great potential for linking data and knowledge within medical information systems. It helps to detail each level of data fusion, reveal problems that need further research and describe use cases for Semantic Web instruments.
CONCEPTUAL DESIGN OF INTELLIGENT DECISION SUPPORT SYSTEMS
Authors:   Moscow Technological University (MIREA), Sorokin A.
Published: June 2018

In article the original technique of conceptual design of decision support systems for solving of problems in dynamically difficult environment is explained. For creation of conceptual model, it is offered to research dynamically difficult environment in three aspects: system views, activity approach (G.P. Shhedrovickij) and situation analysis (L.S. Bolotova). The triad of the considered representations leads to the construction of the conceptual structure of the act of activity, which is positioned as a knowledge base for the design of expert systems of the production type. From the realized conceptual structure, particular representations are distinguished: functions, processes, context and regularities. This makes it possible to determine the necessary field of knowledge about the subject area for the implementation of cognitive, analytical, evolutionary and simulation models. However the graphic construction of the conceptual model of a dynamically complex environment and its particular representations is a complex and nontrivial task. Therefore, the program complex "Designer + Solver + Interpreter" is developed, which verifies the conceptual model of a dynamically complex environment on completeness and adequacy, and also generates the necessary knowledge base for the design of intelligent models in the form of text files.
PRINCIPLES OF BUILDING THE KNOWLEDGE MANAGEMENT SYSTEM FOR ROCKET AND SPACE ENTERPRISES
Authors:   SEC «Smart Solutions» Ltd., Lakhin O. , Yurygina Y. ,   SEC «Smart Solutions» Ltd., Anisimov A. ,   SEC «Smart Solutions» Ltd.
Published: June 2018

The paper presents an important problem of the rocket and space industry: increasing the efficiency of use of accumulated knowledge in the form of heterogeneous documents describing results of intellectual activity. To solve this problem, it is proposed to use the knowledge management system built on the basis of new technologies. Its novelty lies in the use of ontology of domains (Semantic Web) and "multi-agent Internet" as an intellectual base for knowledge management for rocket and space industry enterprises and the entire industry. The paper analyzes and compares available ontology editors and points out their advantages and disadvantages. The paper also gives an example of using the proposed approach for describing the ontology, and provides a mechanism for creating a semantic descriptor based on the design and operational documentation for a product. The results are presented in the form of the developed methods and tools for building knowledge management systems. Practical use of the knowledge management system can improve efficiency of reuse of results of intellectual activity, increase productivity of experts in the rocket and space industry through semantization of accumulated material, as well as improve semantic support of communication and interaction processes between industry employees and experts.
COMPUTATIONAL ASPECTS OF ESTABLISHING UNIVERSAL TABLES OF CRITERION'S IMPORTANCE
Authors:   Samara State Technical University, Piyavsky S.
Published: June 2018

In work “How do we digitize the concept of «more important»” the author had proposed an approach towards decisionmaking in multi-criterial comparison of alternatives that would allow to increase the validity and decrease laboriousness of the process. The method is based on preemptive calculation of universal tables of weight coefficients for linear convolution of criterions. This deems unnecessary calculation of those weights every time a decision is made within the considered system. For every set of criterions, a separate table is made. It contains 2n-1 rows, where n is the number of criterions. Every row corresponds to a unique possible criterions distribution amongst the importance groups. With more criteria, the computational complexity is so great that the computer's power is not enough to get the result in an acceptable time. This paper presents an approach that makes it possible to decrease the calculation complexity of a single table by 2n-1 times. It is made possible due to the observation of so-called “boundary effect”. It shows as repetition of coefficients in different rows of the table. Due to this, a system of linear algebraic equations can be formed, the variables of which are the sought values of the coefficients. The system is easily solved by numerical methods if the coefficients corresponding to one of the rows of the table become known. The proposed approach greatly facilitates the construction of universal tables for a considerably large (several dozen) number of criteria and reduces the amount of memory required from the decision support systems that use this approach. It also allows a deeper understanding of the rational basis of the concept of "more important", used in all areas of human activity.
THE METHOD OF SOLUTION OF THE PROBLEM OF ADDITIONAL INFORMATION REQUEST
Authors:   Institute for Automation Control Processes of the FEB RAS, Kleschev A. , Gribova V. ,   Institute for Automation Control Processes of the FEB RAS, Shalfeeva E. ,   Institute for Automation Control Processes of the FEB RAS
Published: June 2018

The article considers a problem of additional information request, usually being solved in diagnostics process for reduction of number of diagnosis hypotheses. In practice during solution of these two tasks it is important to consider all types of the cause-and-effect relations, variability of signs values for a time, influence of events on dynamics of values of signs. The offered algorithm of solution of this task is based on choosing differentiators among the known measurable signs. Identification of differentiators is made with use of knowledge of internal processes developing and external events’ influence on them. We will apply such algorithm to the solution of a problem of request of additional information for situations recognition, classification and diagnostics in various spheres of activity.
METRICS OF A COMPLEX DETERMINATE SYSTEM
Authors:   Research and Design Institute of design information, automation and communication on railway transport, Tsvetkov V. , Buravtsev A. ,   Institute of Information Technologies and Computer-Aided Design of Moscow Technological University (MIREA)
Published: June 2018

The article is devoted to investigation of complex determinate systems. The paper analyzes the concept of a complex system, applicable for various problems and phenomena. The article shows that the classical definitions of complex systems do not take into account the number of elements and the capacity of the formal description of a complex system. The article considers description of complex systems, given by G. Rzhevsky. It is shows that it does not cover closed and deterministic systems. The paper shows that the theory of complex systems developed by Hiroki Sayama is more general in relation to the theory of systems of Bertalanffy and Mesarovic. The article analyzes Halstead's metrics applied in the field of software, and proves their ideological acceptability to the description of complex systems despite being formally inapplicable. The authors introduce three metrics of a complex deterministic system to differentiate complex systems by the number of elements and content. The article gives description and substantiation of these concepts metrics. Authors reveal the main problem of describing complex systems - finding a balance between the simplicity of describing the system model and preserving the essential characteristics of the complexity of the system.
ONTOLOGY-BASED APPROACH TO MODELING THE PROCESS OF EXTRACTING INFORMATION FROM TEXT
Authors:   A.P. Ershov Institute of Informatics Systems SB RAS, Sidorova E.
Published: June 2018

The article deals with models and methods of knowledge representation, focused on tasks of automatic text processing and information extraction. In the framework of our approach, information extraction is considered as a process of ontology population with information represented as instances of domain concepts. To describe this process three basic models are proposed. The model of the text representation defines the general scheme of text processing and provides the mapping of the received information on the text. The knowledge representation model includes a description of the subject vocabulary, genre models of the text and the models of facts, which allow modeling the processes of information extraction in terms of semantic classes of subject vocabulary and ontology of the subject domain. The attributive model of data representation ensures the preservation of information streams of data that arise in the process of extracting information, and allows the use of ontological methods for solving ambiguity problems and resolving the coreference. Thus, an original technique that allows users to design a text analysis system and simulate the information extraction based on the domain ontology is proposed.
MEDICAL DIAGNOSIS ONTOLOGY FOR INTELLIGENT DECISION SUPPORT SYSTEMS
Authors:   Institute of Automation Control Processes of the FEB RAS, Gribova V. , Petryaeva M. ,   Institute of Automation Control Processes of the FEB RAS, Okun D. ,   Institute of Automation Control Processes of the FEB RAS, Shalfeeva E. ,   Institute of Automation Control Processes of the FEB RAS
Published: June 2018

An ontology for representation of knowledge about the diagnosis of diseases and syndromes is described. It allows experts to represent knowledge about the diagnosis of a wide range of diseases. Knowledge of the disease diagnosis including its form, etiology, pathogenesis, variants of the clinical course is represented according to their clinical classification: a set of diagnostic features, alternative symptom complexes with pre-morbid biological, personality and other factors, dynamic signs of symptoms and clinical features altered by the impact of events. The ranking of symptoms by specificity is possible, as well as a description of the conditions predisposing or contributing to the disease, which allows to attribute the disease with a set of specific features. The article includes an informal description of the ontology, as well as its model with a description of the main terms, knowledge, situations and limitations of their integrity in the form of ontological agreements. An example of the use of the ontology for the formation of a knowledge base on diagnosis and differential diagnosis of diseases from the group "Diseases of the digestive organs" is given in the article. The ontology is implemented on the cloud platform of IACPaaS and now is actively used by experts to create knowledge bases in various fields of medicine.
PROPOSITION OF A SECURE SYSTEM OF VOTING USING UIDAI DATA VIA IOT
Authors: Chakrabarti Shakya , Acharya Neelanjan
Published: June 2018

Purpose of the study: The paper proposes a secure system of voting using UIDAI Data and implementing IoT to save a copy of the voting statistics via VMAC encryption. Methodology: The paper proposes a secure system which will utilize the Aadhar database along with the Electronic Voting Machine units, to authenticate voters by bio-metric means which will be synchronized by Internet of Things. After successful casting of vote, two sets of voting statistics will be stored in the local polling station as well as a centralized register respectively; through a cascade of servers. These will be secured from virtual third-party vulnerability by VMAC encryption. Finally, an impenetrable system of voting can be established by the above method. Applications of this study: If the proposed system of voting is practically implemented, then a proper consensus can be obtained by avoiding poll-day violence. Furthermore, if UIDAI data is used then the voter’s authenticity is also verified. Novelty/Originality of this study: The use of biometric data, as well as storage of a second set of data using VMAC encryption to a secondary storage site.
Controlador Robusto Quasi-Deadbeat e Relaxações com Aplicação em Inversores Conectados à Rede
Authors: Osório Caio R. D. , Koch Gustavo G. , Borin Lucas C. , Cleveston Iury , Montagner Vinícius F.
Published: June 2018

Este trabalho apresenta o projeto de um controlador robusto de corrente por realimentação de estados baseado em desigualdades matriciais lineares, conduzindo a um conjunto de ganhos fixos capaz de garantir a alocação dos polos de malha fechada em um círculo de raio mínimo, centrado na origem e contido no círculo de raio unitário (controlador robusto quasi-deadbeat). Para aplicações em conversores conectados à rede, o procedimento de projeto proposto produz resultados ilustrando que relaxações a partir do controlador robusto quasi-deadbeat garantem estabilidade e bom desempenho para uma faixa de incertezas e para variações nos parâmetros da rede e do filtro.
Controle Preditivo Baseado em Modelo para Sistema Eólico Empregando Gerador de Indução Gaiola de Esquilo
Authors: Lunardi Angelo S. , Filho Alfeu J. Sguarezi
Published: June 2018

Este artigo propõe um controlador preditivo baseado em um modelo aplicado no gerador de indução de gaiola de esquilo usando um controle direto de torque. O sistema é composto por um gerador, que é conectado à rede de energia através de um conversor back-to-back. O conversor conectado à rede emprega a técnica de controle preditivo direto de potência. Sendo assim, é possível controlar a potência ativa e reativa que será injetada na rede. O controlador preditivo não necessita de sintonia e possui menor complexidade de implementação. Em ambos os casos, o controlador preditivo seleciona o vetor ótimo a ser aplicado no conversor do gerador ou no conversor da rede elétrica através da minimização de uma função custo, de forma que as referências sejam atendidas. Os resultados experimentais mostrarão o desempenho do controlador preditivo proposto.
Conversor CC-CC de Alto Ganho Voltado para Aplicações Fotovoltaicas com Módulos de Filme Fino
Authors: Schmitz Lenon , Horn Thamires P. , Martins Denizar C. , Coelho Roberto F.
Published: June 2018

Este artigo propõe um novo conversor cc-cc não isolado de alto ganho baseado no clássico conversor Buck síncrono com indutor acoplado e multiplicadores de tensão. Além de apresentar baixos esforços de tensão nos interruptores, o conversor proposto permite uma menor utilização magnética quando comparado a conversores baseados na topologia Boost, levando a uma estrutura mais compacta. Seu modo de operação ressonante possibilita comutação com tensão nula na ativação dos interruptores e comutação com corrente nula no bloqueio dos diodos, o que aumenta seu rendimento. Resultados experimentais obtidos a partir de um protótipo de 150 W, capaz de operar com uma grande variedade de módulos de filme fino, com tensão de entrada de 55-85 V e tensão de saída de 400 V, mostram que o rendimento máximo obtido é de 98,0% e os rendimentos ponderados da Comissão de Energia da Califórnia (CEC) são superiores a 96,7% em toda a faixa de tensão de entrada.
Development of a Didactic Workbench Using Real-Time Monitoring System for Teaching of Photovoltaic Systems
Authors: Silva Sérgio A. Oliveira da , Wollz Danilo H. , Sampaio Leonardo P.
Published: June 2018

This paper presents the deployment of a didactic workbench intended to support theoretical and practical studies addressed in subjects of undergraduate and postgraduate electrical engineering courses involving photovoltaic (PV) systems. The proposed system operates in real-time and is composed of a computational graphic interface operating in conjunction with a double-stage PV system connected to the power grid. Besides the PV array, the PV system consists of a step-up DC-DC converter, intended to track the maximum power point, and a current-controlled full-bridge inverter, intended to inject the energy produced by the PV array into the grid. The monitoring system allows to perform the following tasks: i. assist the performance evaluation of maximum power point tracking techniques tied to projects; ii. visualize the measured PV array magnitudes (voltage, current and power), as well as the estimated ones calculated from the PV array mathematical model and from the real measured values of solar irradiation and temperature; iii. analyze electric power quality indicators, based on the grid voltage and current magnitudes, and others. Experimental results are presented with the objective of testing and evaluating the versatility of the proposed didactic workbench applied in an educational environment.
Conversor Duplo-Boost-Flyback de Alto Ganho
Authors: Cardoso Vanderlei , Lazzarin Telles B. , Waltrich Gierri
Published: June 2018

Um conversor CC-CC não isolado de alto ganho é proposto nesse artigo, o qual é denominado Duplo-Boost-Flyback de Alto Ganho pelo fato de combinar dois conversores Boost-Flyback convencionais, conectados em paralelo na entrada e com saída flutuante. Essa nova topologia aumenta o ganho estático do conversor e reduz a ondulação da corrente de entrada. A topologia proposta é ideal para aplicações com fontes de alimentação com baixa tensão que precisam elevar consideravelmente a tensão para ser utilizada, como por exemplo, arranjos fotovoltaicos, células combustíveis e baterias. Este artigo apresenta princípio de operação, ganho estático, estratégia de controle e exemplo de projeto. A verificação experimental foi realizada a partir de um protótipo de 1 kW com tensão de entrada de 48 V e saída de 800 V, alcançando o ganho estático de 16,7. A eficiência máxima apresentada foi de 94,6% com 70% da carga e 93,9% com carga nominal.
Kikuchi-Fujimoto disease mimicking hematological malignancy: a case report
Authors: Yarkıcı Hakan , Elyiğit Faruk , Peker Ahmet , Solakoğlu Kahraman Dudu , Erbil Nilgün , Akar Harun
Published: June 2018

Kikuchi-Fujimoto
disease or histiocytic necrotizing lymphadenitis is a benign histopathological
condition and a rare cause of lymphadenopathies. This disease which is seen in
women around the age of 30 in the far east countries is generally presented
with lymphadenopathy, fever, weight loss, and myalgia symptoms. In this
article, we would like to present a case of Kikuchi-Fujimoto disease in the
histopathology of the lymph node excision, which was examined in terms of
lymphadenopathy.
Further Results on Locating Chromatic Number for Amalgamation of Stars Linking by One Path
Authors: Asmiati A. , Yulianti Lyra , Widyastuti C. Ike Tri
Published: June 2018

Let G = (V,E) be a connected graph. Let c be a proper coloring using k colors, namely 1, 2,·s, k. Let P={S1, S2,..., Sk} be a partition of V(G) induced by c and let Si be the color class that receives the color i. The color code, cP(v)=(d(v,S1), d(v,S2),...,d(v,Sk)), where d(v,Si)=min {d(v,x)|x Î Si} for i Î [1,k]. If all vertices in V(G) have different color codes, then c is called as the \emphlocating-chromatic k-coloring of G. Minimum k such that G has the locating-chromatic k-coloring is called the locating-chromatic number, denoted by cL(G). In this paper, we discuss the locating-chromatic number for n certain amalgamation of stars linking a path, denoted by nSk,m, for n ≥ 1, m ≥ 2, k ≥ 3, and k>m.
Characterizing an ideal experimental canine model for penile sentinel lymph node identification
Authors: Leitão Bruno Tigre de Arruda , Okoba Willy , Bezerra Diego Aragão , Mesquita Neto Jose Wilson Benevides de , Cruz Diego Alves , Pinheiro Luiz Gonzaga Porto
Published: June 2018

Objective: Develop and evaluate a canine experimental model of penile sentinel lymph node (SLN) detection using a combination of patent blue dye (PB) and technetium99m phytate (99mTc). Methods: The experiment sampled healthy adult male mongrel dogs (N=19; 10-20 kg). After approval by the local ethics committee, we injected99mTc in the glans penis along the midline raphe. After 10 min, PB was injected in the same region. Ten minutes later, we identified hot spots within the inguinals and iliac artery areausing a gamma probe. We dissected identified sites to quantify the radiation at the SLN in vivo and ex vivo and accounted for the stained and unstained nodes. We analyzed the results for statistical significance and determined the level of agreement between the two methods. Results: SLNs were detected in 94.76% of the cases using PB and 99mTc. There was no difference (p>0.05) between the SLNs-count on the left and the right side. However, PB and 99mTc correlated well on the right side (kappa index: 0.642) and perfectly on the left side (kappa index: 1), indicating a high level of consistency. Conclusion: The experimental canine model of penile SLN, in our study, was shown to be feasible.
Fatores relacionados à detecção de displasia em pacientes com esôfago de Barrett longo do Hospital Universitário Walter Cantídio
Authors: Rios Nikaelle Ximenes , Guimarães Danilo Frota , Melo Isabele De Sá Silveira , Ponte Cynthia Aben Athar , Franco Luciano Monteiro , Souza Miguel Ângelo Nobre e , Souza Marcellus Henrique Loiola Ponte de
Published: June 2018

Introdução: pacientes com doença do refluxo gastroesofágico (DRGE) têm de 10 a 15% de chance de desenvolver esôfago de Barrett. Este pode evoluir para displasia e adenocarcinoma esofágico. Objetivo: avaliar fatores relacionados à detecção de displasia em pacientes com esôfago de Barrett longo. Metodologia: estudo retrospectivo com análise de informações de 18 pacientes com diagnóstico de esôfago de Barrett longo, colhidas de bancos de dados dos serviços de Endoscopia e Patologia e prontuários do Hospital Universitário Walter Cantídio (HUWC-UFC), no período de 2010 a 2015. Os pacientes foram divididos em dois grupos para comparação, grupo sem displasia (N=11) e grupo com displasia/adenocarcinoma (N=7). Resultados: do total de 18 pacientes com esôfago de Barrett longo no HUWC, 72% eram do sexo masculino, 47% tinham mais de 50 anos, 64% apresentavam sintomas típicos de DRGE, 23% eram tabagistas, 77% tinha hérnia hiatal, 50% realizaram fundoplicatura. Não houve diferenças estatísticas destas características entre o grupo com e sem displasia. Entretanto, o grupo com displasia teve uma média de 5 endoscopias/paciente, enquanto o grupo sem displasia teve apenas 2 endoscopias/paciente(p<0,05). Conclusão: O maior número de endoscopias realizadas foi um fator relacionado à maior detecção de displasia/adenocarcinoma em pacientes com esôfago de Barrett no HUWC-UFC.
Salt Stress Induces Non-CG Methylation in Coding Regions of Barley Seedlings (Hordeum vulgare)
Authors: Konaté Moumouni , Wilkinson Michael J. , Mayne Benjamin T. , Pederson Stephen M. , Scott Eileen S. , Berger Bettina , Rodriguez Lopez Carlos M.
Published: June 2018

Salinity can negatively impact crop growth and yield. Changes in DNA methylation are known to occur when plants are challenged by stress and have been associated with the regulation of stress-response genes. However, the role of DNA-methylation in moderating gene expression in response to salt stress has been relatively poorly studied among crops such as barley. Here, we assessed the extent of salt-induced alterations of DNA methylation in barley and their putative role in perturbed gene expression. Using Next Generation Sequencing, we screened the leaf and root methylomes of five divergent barley varieties grown under control and three salt concentrations, to seek genotype independent salt-induced changes in DNA methylation. Salt stress caused increased methylation in leaves but diminished methylation in roots with a higher number of changes in leaves than in roots, indicating that salt induced changes to global methylation are organ specific. Differentially Methylated Markers (DMMs) were mostly located in close proximity to repeat elements, but also in 1094 genes, of which many possessed gene ontology (GO) terms associated with plant responses to stress. Identified markers have potential value as sentinels of salt stress and provide a starting point to allow understanding of the functional role of DNA methylation in facilitating barley’s response to this stressor.
Small Scale Modular Multilevel Converter for Multi Terminal DC Networks Applications: System Control Validation
Authors: Talon Louokdom Elie , Gavin Serge , Siemaszko Daniel , Biya-Motto Frédéric , Essimbi Zobo Bernard , Marchesoni Mario , Carpita mauro
Published: June 2018

This paper presents the design and implementation of a digital control system for modular multilevel converters (MMC) and its use in a 5-kW small scale prototype. To achieve higher system control reliability and multi-functionality, the proposed architecture has been built with an effective split of the control tasks between a master controller and six slave controllers, one for each of the six arms of the converter. The MMC prototype have been used for testing both converter and system level controls in a reduced scale laboratory set up of a Multi-Terminal DC transmission network (MTDC). The whole control has been tested in order to validate the proposed control strategies. The tests performed at system level allowed to explore the advantages of using an MMC in a MTDC system.
Potential Role of NRF2 Agonist in Managing AHR-Mediated Chloracne by Dioxin
Authors: Furue Masutaka , Fuyuno Yoko , Mitoma Chikage , Uchi Hiroshi , Tsuji Gaku
Published: June 2018

Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-related factor-2 (NRF2) is a master switch inducing expression of various antioxidative enzymes such as heme oxygenase-1. Cinnamaldehyde is an antioxidant phytochemical that inhibits AHR–CYP1A1 signaling and activates the NRF2–antioxidative axis. The cinnamaldehyde-containing Kampo herbal medicine Keishibukuryogan is capable of improving chloracne in Yusho patients who are highly contaminated with dioxin. Agents with dual functions in promoting AHR–CYP1A1 inhibition and NRF2 activation may be useful in managing dioxin-related health hazards.
Building Principles for Constructing a Mammalian Blastocyst Embryo
Authors: Pfeffer Peter L.
Published: June 2018

The self-organisation of a fertilised egg into an embryo of three distinct cell lineages (trophoblast, epiblast and hypoblast) arranged around an off-centre cavity typifies the blastocyst, an embryonic structure that is unique to mammals. While the starting point (the zygote) and endpoint (the blastocyst) are similar in all mammals, the intervening events have diverged. This review examines and compares the descriptive and functional data surrounding embryonic gene activation, symmetry-breaking, first and second lineage establishment and fate commitment in a wide range of mammalian orders. The exquisite detail known from mouse embryogenesis, embryonic stem cell studies and the wealth of recent single cell transcriptomic experiments are used to highlight the building principles underlying early mammalian embryonic development.
SpainUDP: The Spanish Undiagnosed Rare Diseases Program
Authors: López Martín Estrella , Martínez-Delgado Beatriz , Bermejo-Sánchez Eva , Javier Alonso , Posada Manuel
Published: June 2018

One of the IRDiRC goals for 2017-2027 is to achieve definitive diagnosis for rare undiagnosed diseases within one year, as diagnosis delay remains one of the pending issues in the rare diseases field. The Spanish Undiagnosed Rare Diseases Program (SpainUDP) was created in response to this challenging scenario to cover patients’ needs and after seeing the success of the UDP in USA. SpainUDP offers a multidisciplinary approach to those patients who have long sought a diagnosis without any success. During a first phase of the protocol, undiagnosed cases are sent to SpainUDP by individual patients, patient organizations or hospitals. After a carefully analysis of phenotype, data from sequencing experiments (WES) is processed with a standard pipeline and a detailed standardized phenotypic information (mapped to HPO) is connected to genetic data. In addition, the participation of SpainUDP in international initiatives such as the European projects RD-Connect and Solve RD, the Undiagnosed Diseases Network International (UDNI), and the MatchMaker Exchange platform, allows the establishment of a global data sharing strategy across multiple projects submitting data to these international initiatives. From the official beginning of the program (at the end of 2015) until early 2018, 147 cases were accepted in SpainUDP. During this time, 37 cases (25 %) dropped out the program due to several reasons. The remaining 110 cases are distributed as follows: phenotypic and genotypic (WES) characterization was finished in 30 cases, of which 20 (67 %) were diagnosed; 21 cases are pending on variants validation by Sanger; in 25 cases, WES is ongoing and 34 cases are in a deep phenotypic characterization. As a conclusion, SpainUDP aims to achieve a diagnosis following two recommendations of the IRDiRC: the patients’ diagnosis in a period of time as short as possible and the promotion of data sharing (especially genomic) at the international level.
The Singularity May Be Near
Authors: Yampolskiy Roman V.
Published: June 2018

Toby Walsh in “The Singularity May Never Be Near” gives six arguments to support his point of view that technological singularity may happen but that it is unlikely. In this paper, we provide analysis of each one of his arguments and arrive at similar conclusions, but with more weight given to the “likely to happen” probability.
Exploring Multi-Disciplinary Communication Based on Generative Modeling at the Early Architectural Design Stage
Authors: Chang Yi Feng , Shih Shen Guan
Published: June 2018

The purpose of interdisciplinary communication during the early architectural design stage is to achieve the early integration of knowledge in different professional fields, which can help architects to choose correct design development strategies during the early architectural design stage. However, because there is too little information at the early design stage, and design solutions are still rapidly changing and developing, the uncertainties at this stage make it difficult for consultants in other disciplines to provide their views and analysis. In spite of this situation, the emergence of generative modeling is changing design procedures and methods of communication and cooperation for architectural teams, and has brought about a shift in the way architects transmit design information from "what" (declarative information) to "how" (procedural information). Generative modeling is like an aircraft's dashboard: It can provide a basis for interdisciplinary communication, provide interdisciplinary knowledge packages, and bring about a shift in interdisciplinary communication that will reduce the architectural team's communication needs and cost. This study uses a real design case to show the feasibility of generative modeling. Employing generative modeling as a basis, architects can enhance the efficiency of design change and multi-disciplinary communication during the early design stage, integrate specialized knowledge in relevant fields, use this knowledge to formulate design criteria for the next stage, and effectively transmit design decisions. As a consequence, the changes to the cost structure of design revisions and communication between different disciplines has initiated a paradigm shift toward multi-disciplinary communication in architectural design.
Biochars Improve Nutrient Retention Capacity of Highly Weathered Tropical Soils
Authors: Berek Arnoldus , Hue Nguyen , Radovich Theodore , Ahmad Amjad
Published: June 2018

Highly weathered soils in the tropics are low in fertility, negatively affecting plant growth. The potential of biochar for improving soil nutrient retention is reportedly promising, triggering this study to assess the nutrient retention capacities of two biochars when applied at 2% in combination with two composts also applied at 2% to an Ultisol (Ustic Kanhaplohumult, Leilehua series) and an Oxisol (Rhodic haplustox, Wahiawa series) of Hawai’i. Chinese cabbage (Brassica rapa cv. Bonsai) was used as the test plant in two greenhouse plantings, which had a factorial completely randomized design with three replicates per treatment. The results indicated that the combined additions of biochar and compost significantly increased the pH, EC, P and K of the soils; improved Ca, Mg and Fe uptake; and increased shoot and total cabbage fresh and dry matter. Exchangeable aluminum in the Ultisol was decreased from 2.5 cmol+/kg to virtually zero. Extractable Mn and Fe in the high Mn-Oxisol were decreased by 55 and 42%, respectively. Chinese cabbage growth in the Ultisol amended with the lac tree (Schleichera oleosa) wood biochar and vermicompost was almost twice over lime at 2 cmol+/kg. Essential nutrients in the plant tissues, with the exception of N and K, were sufficient for the cabbage growth, suggesting increases in nutrients and reduced soil acidity by the additions of biochar combined with compost were the probable cause.
A radio-fluorogenic polymer-gel makes fixed fluorescent images of complex radiation fields
Authors: Warman John , deHaas Matthijs , Luthjens Leonard , Denkova Antonia , Yao Tiantian
Published: June 2018

Abstract: We review the development and application of an organic polymer-gel capable of producing fixed, three-dimensional fluorescent images of complex radiation fields. The gel consists for more than 99% of γ-ray-polymerized (~15% conversion) tertiary-butyl acrylate (TBA) containing ~100 ppm of a fluorogenic compound, e.g. maleimido-pyrene (MPy). The radio-fluorogenic effect depends on copolymerization of the MPy into growing chains of TBA on radiation-induced polymerization. This converts the maleimido residue, which quenches the pyrene fluorescence, into a succinimido moeity (SPy), which doesn't. The intensity of the fluorescence is proportional to the yield of free-radicals formed and hence to the local dose deposited. Because the SPy moieties are built into the cross-linked polymer matrix the image is fixed. The method of preparing the gel and imaging the radiation-induced fluorescence are presented and discussed. The effect is illustrated with fluorescent images of the energy deposited in the gel by beams of X-rays, electrons and protons as well as a radioactive isotope.
Exposing the Fundamental Role of Spectral Scattering in the PFT Signal
Authors: Robertson Lain Lisl , Bernard Stewart
Published: June 2018

There is increasing interdisciplinary interest in phytoplankton community dynamics as the growing environmental problems of water quality (particularly eutrophication) and climate change demand attention. This has led to a pressing need for improved biophysical and causal understanding of Phytoplankton Functional Type (PFT) optical signals, in order that satellite radiometry may be used to detect ecologically relevant phytoplankton assemblage changes. This understanding can best be achieved with biophysically and biogeochemically consistent phytoplankton Inherent Optical Property (IOP) models, as it is only via modelling that phytoplankton assemblage characteristics can be examined systematically in relation to the bulk optical waterleaving signal. The Equivalent Algal Populations (EAP) model is used here to investigate the source and magnitude of size- and pigment- driven PFT signals in the water-leaving reflectance, as well as the potential to detect these using satellite radiometry. This model places emphasis on explicit biophysical modelling of the phytoplankton population as a holistic determinant of IOPs, and a distinctive attribute is its comprehensive handling of the spectral and angular character of phytoplankton scattering. Selected case studies and sensitivity analyses reveal that phytoplankton spectral scattering is the primary driver of the PFT-related signal. Key findings are that the backscattering-driven signal in the 520 to 600 nm region is the critical PFT identifier at marginal biomass, and that while PFT information does appear at blue and red wavelengths, it is compromised by biomass/gelbstoff ambiguity in the blue and low signal in the red, due primarily to absorption by water. These findings are hoped to provide considerable insight into the next generation of PFT algorithms.