bluuebunny/crossref_metadata_2025 huggingface dataset:
DISEASES OF PASSING SALMON FISH DURING ARTIFICIAL REPRODUCTION IN THE CONDITIONS OF THE FAR NORTH OF THE FAR EAST
Authors:   Magadan Scientific Research Institute of Agriculture – a branch of the Federal State Budgetary Educational Institution FITZ All-Russian Institute of Plant Genetics named after N.I. Vavilov, Vitomskova E.A.
Published: October 2024

Replenishment of fish stocks by increasing the release of juveniles during artificial fish farming is currently an urgent problem in the Far North of the Far East. In 1995-2003; 2021, an epizootological survey of natural spawning grounds and fish farming enterprises located in the northern part of the Okhotsk Sea basin was conducted: Ola, Arman, Taui, Yana, Iret, Ola experimental production acclimatization base, Armansky, Taui, Yansky salmon hatcheries. The aim is to study bacterial and protozoal diseases of passing salmonids in artificial fish farming. The novelty of the research is that for the first time in the waters of the northern part of the Okhotsk Sea basin, bacterial and parasitic diseases were detected in passing salmon fish in natural reservoirs during anadromous migration and artificial fish farming. In pink salmon, chum salmon, coho salmon, sockeye salmon, Aeromonas hydrophila culture isolated from blood and internal organs turned out to be virulent. Aeromonosis was established for the first time in passing salmon fish of natural populations. As a result of bacteriological studies, Aeromonas hydrophila bacteria were isolated from different batches of fertilized eggs, yolk sac of larvae, ascitic fluid of the abdominal cavity of juveniles. Due to the detection of the invasion of juvenile fish Trichodina truttae and Myxosoma cerebralis, which amounted to 10.0-46.5%, trichodyniosis and myxosomiasis were registered. The ways of transmission of infection to fish farms have been established. Fertilized eggs are infected from producers on spawning rivers during the selection of sexual products. The epizootological situation of aeromonosis, trichodyniosis and myxozomiasis is recognized as unfavorable. The method of diagnosis of bacterial diseases of salmonids at fish-breeding enterprises of the region has been improved.
DISTRIBUTION OF PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER (PFCRT) AND PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE 1(PFMDR-1) GENES IN ILORIN NORTH-CENTRAL NIGERIA
Authors: Abdulraheem Jimoh O. , Olalubi Oluwasogo , Awe Sunday
Published: October 2024

Globally, malaria is a peculiar health challenge particularly in continent of Africa. The ease of developing resistance to anti-malaria drugs by Plasmodium falciparum is a serious impediment towards programs aim at control and elimination of malaria. Consequently, drug efficacy surveillance is desirable to institute adequate and effective treatment policies. In this study, distribution of these genes in Plasmodium falciparum isolates in Ilorin metropolis were investigated. One hundred and three samples collected randomly from 5 hospitals in Ilorin metropolis. The samples were amplified at codon 76 and 86 for Pfcrt and Pfmdr-1 respectively using PCR / Restricted Fragment Length Polymorphism (RFLP). The most prevalent alleles were drug susceptible alleles in the study area (K76 and N86) with 31% and 40% respectively, while drug resistance alleles (86Y) have 13% and the least prevalence 2% was the mixed alleles K76T.  UITH has the highest number of susceptible alleles followed by CSC 38% and 46% for K76 and N86 respectively. There are significant differences in the distribution of these alleles and the study sites (P< 0.05). The prevalence of resistance alleles in the area is a welcome development that can be employed for possibility of re-introduction of CQ for the treatment of malaria in the study area which will serve as an advantage over expensive ACT due to fact that it is safe cheap and readily affordable.
Linguistica sine finibus: estudis dedicats a Montserrat Batllori Dillet
Authors: Massanell Messalles Mar , Pérez Saldanya Manuel , Rigau Oliver Gemma , C. Wolfsgruber Anne , Bargalló Escrivà Maria , Iglésias Narcís , Gavarró Algueró Anna , Jo Galí Sergi , Mateu Jaume , Royo Carles , Claveria Nadal Glòria , García Rodríguez Joseph , Prat Sabater Marta , Julià Luna Carolina , Lleal Galceran Coloma , Buenafuentes De La Mata Anna , Bartra‑Kaufmann Anna , Llach Carles Sílvia , Hernanz Carbó Maria Lluïsa , Pujol Payet Isabel , Acedo‑Matellán Víctor , Ferrerós Pagès Carla , Roca Urgell Francesc , Hill Virginia , Mare María , Martins Ana Maria , Sánchez Lancis Carlos , Sitaridou Ioanna , Lee Tristan , Torruella Joan
Published: October 2024

Aquest llibre és un homenatge que companys i col·legues oferim a Montserrat Batllori amb motiu de la seva jubilació, en agraïment a tot el que ens ha regalat al llarg de la seva trajectòria acadèmica. El títol de l’obra, «Linguistica sine finibus», és a dir, lingüística sense fronteres, vol posar en relleu la concepció oberta que ha caracteritzat tant la seva recerca com la seva docència en l’àmbit de la lingüística. El volum, que aplega vint-i-un treballs vinculats a les diferents àrees d’estudi a les quals Batllori ha dedicat la seva carrera, s’estructura al voltant dels eixos temàtics següents: (i) variació geolectal i variants romàniques, (ii) variació diacrònica, (iii) història de la llengua, (iv) estructura argumental: teoria i aplicacions, i (v) anàlisi de corpus. L’originalitat de les contribucions i la diversitat de marcs teòrics i metodològics emprats fan d’aquest volum una obra de gran rellevància científica per a l’estudi de la llengua des de tots els seus vessants, alhora que reflecteixen la transversalitat de l’homenatjada.
Restrictive relative clauses in Acadian French
Authors: Hill Virginia
Published: October 2024

Restricted relatives in Acadian French display the following peculiarities: generalization of que ‘that’ as the relative complementizer; deletion of "que" ‘that’; orphaned prepositions; failure of subject‑verb agreement between the relative noun and the embedded verb. This paper argues that such peculiarities arise from the tendency of Acadian French to use a matching rather than a raising pattern of derivation in restrictive relatives, which further involves non‑quantificational chains. This parametric setting, discussed here for the first time, contrasts with the systematically raising pattern in the restrictive relative of Standard French.
"E portava‑li hom ·I· pali d’aur". Pèrdua i supervivència d’un pronom impersonal
Authors: Bartra‑Kaufmann Anna
Published: October 2024

L’ús dels pronoms indefinits formats per gramaticalització dels noms que designen l’ésser humà és un recurs emprat en moltes llengües per denotar una referència indetermminada o impersonal amb interpretació semàntica existencial o genèrica (suec "man"; alemany "man"; abruzzès "nome"; francès, "on"; català "hom"; espanyol antic "omne"). Però la pervivència d’aquestes formes ha sofert una sort diversa. Defensem la hipòtesi que la pervivència o desaparició dels indefinits depèn dels seus trets formals, de la seva distribució sintàctica, de l’existència en la llengua d’estructures o unitats competidores i de qüestions externes com l’ús i les connotacions de registre. Ens centrarem en el català, tot focalitzant sobre el procés de gramaticalització de hom. Conclourem que la competició de "hom" amb altres estratègies de valor semàntic similar i la connotació de registre l’han convertit en una forma poc usual en la llengua col·loquial d’algunes zones.
La fossilització de l’enclisi en preguntes exclamatives gramaticalitzades com a marcadors modals
Authors: Massanell Messalles Mar
Published: October 2024

Aquest treball tracta de les preguntes exclamatives "Vols‑te creure que...?!" i "Vols‑t’hi jugar que...?!", emprades com a marcadors modals en alguns parlars catalans, i té com a objectiu justificar‑hi l’enclisi dels pronoms febles, la qual contravé la gramàtica del català contemporani. A través de l’anàlisi de mostres obtingudes del Corpus Informatitzat del Català Antic (CICA), s’evidencia que l’adjunció del clític pronominal darrere de la forma verbal finita era la ubicació àmpliament predominant en català antic en les oracions principals afirmatives neutres de verb inicial. Aquesta constatació permet de suposar que les construccions analitzades remunten al període de vigència de l’enclisi, la qual devia quedar‑hi fossilitzada de resultes dels processos de gramaticalització que van convertir "Vols‑te creure que...?!" en un marcador modal de sorpresa i "Vols‑t’hi jugar que...?!" en un marcador modal epistèmic equivalent a la perífrasi de probabilitat amb "deure", però amb una càrrega emfàtica que aquesta no té.
De quan "NO" sembla més una afirmació que no pas una negació
Authors: Lleal Galceran Coloma
Published: October 2024

Els textos del corpus del DiCCA‑XV mostren una presència important de la negació contextual, tradicionalment anomenada expletiva. Els exemples mostren que a les completives amb noms i verbs de temor, amb quantificadors de grau a les estructures comparatives o a les construccions temporals lligades a "antes que, primero que" i similars, l’ús d’aquest tipus de negació és general a tots els tipus de text. En canvi, pràcticament no es dona en estructures temporals duratives del tipus "hasta que", ni tampoc en estructures exclamatives encapçalades per un quantitatiu ponderatiu. Una revisió dels casos mostra que la presència d’aquestes negacion contextuals està lligada a la tipologia textual i, sobretot, a la llengua de la qual s’ha traduït el text. Podem preguntar‑nos si som davant un tret de la llengua, o un tret de la llengua de traducció.
Аnalysis and systematisation of the influence of risks on the innovation and investment activities of the enterprise in the conditions of post-conflict transformation
Authors: Ivchenko Yu.A.
Published: October 2024

Despite the fact that the situation in Ukraine's economy remains challenging, as the economic environment does not create reliable preconditions for economic growth, economic and social problems continue to persist, deepen and exacerbate. The country's economy is currently characterized by a pronounced raw material-based economy with an underdeveloped manufacturing industry. Ensuring qualitative transformational changes in the economy is not possible without consistent capital accumulation of enterprises on a simple and expanded basis. The tools used by domestic enterprises (traditional instruments and methods) to manage innovation and investment activities are imperfect, as they do not allow timely identification and forecasting of possible risks, accurate assessment of the decline in innovation and investment potential and economic sustainability of enterprises. Identification of the cause and effect relationships of crisis phenomena ensures the implementation of the anti-crisis management mechanism in a transformational economy. For successful innovation and investment activities of an enterprise in the context of post-conflict transformation, a qualitative analysis and systematization of the impact of risks is necessary.  The aim of the article is to analyze and systematize the impact of risks on the innovation and investment activity of enterprise in the context of post-conflict transformation. To achieve this goal, all types of risks of innovation and investment activity were systematized according to certain features and depicted schematically. The article analyses approaches to risk definition, investment risks, innovation risks, specific risks, innovation risks according to the subject of innovation, and risks of entrepreneurial activity. It is noted that the analysis of risk impact contributes to the further development of the theory of riskology. It is concluded that systematization of the impact of risks on the innovation and investment activities of enterprise in the context of post-conflict transformation is necessary to formalize the risk management processes at enterprises. The author notes that in the context of military conflict and post-conflict transformations, new types of risks may arise, so this issue requires further research.
Високотехнологічний розвиток міст: цифровий та фінансовий аспекти
Authors: Крисоватий І.А.
Published: October 2024

В представленій роботі акцентовано увагу на те, що усучасному світі високих технологій розвиток міст набуває нових форм і вимірів, які визначаються цифровими та фінансовими аспектами. Тренди цифровізації і технологічних інновацій трансформують не лише способи взаємодії мешканців з міською інфраструктурою, але і саму структуру економічної діяльності міст.
Високотехнологічний розвиток міст, що часто позначається терміном "розумні міста" (smartcities), включає інтеграцію сучасних інформаційних і комунікаційних технологій (ІКТ) у міське управління, що дозволяє покращити якість життя, підвищити ефективність використання ресурсів та зменшити екологічний вплив. Цифрові технології, такі як Інтернет речей (IoT), великі дані (BigData), штучний інтелект (AI) і системи розумного управління трафіком, є ключовими елементами цієї трансформації, забезпечуючи інтегроване управління міською інфраструктурою і надання послуг.
Однак цифровізація міст не може відбуватися без належного фінансового забезпечення. Розвиток інфраструктури і впровадження нових технологій потребують значних інвестицій, які можуть включати державне фінансування, приватні інвестиції, партнерства між державними та комерційними структурами, а також інноваційні фінансові інструменти. Ефективне управління фінансами в цьому контексті стає критично важливим для забезпечення стабільного і сталого розвитку міст. Метою представленої роботи є визначення особливостей впливу фінансування та цифровізації на високотехнологічний розвиток міст. У цьому контексті дослідження цифрових і фінансових аспектів високотехнологічного розвитку міст є надзвичайно важливим для розуміння, як новітні технології і фінансові механізми можуть взаємодіяти для створення ефективних і стійких міських середовищ. Це дозволяє не лише покращити управлінські процеси і підвищити якість життя міських жителів, але й знайти нові шляхи для економічного розвитку і підвищення конкурентоспроможності міст у глобальному масштабі.
Аналіз цифрових та фінансових аспектів високотехнологічного розвитку міст дозволяє виявити ключові фактори, що визначають успіх реалізації інноваційних проектів, а також розробити стратегії, які допоможуть максимально ефективно використовувати доступні ресурси та забезпечити довгостроковий позитивний вплив на міське середовище.
Оптимізація атомної енергії в Україні на засадах екомаркетингу
Authors: Щаслива Л.А.
Published: October 2024

Для ухвалення ефективних управлінських рішень щодоуспішного реформування енергетичного сектору та оптимізації атомної енергії в Україні у відповідність зі щорічним зростанням обсягів відновлювальних джерел енергії необхідно здійснювати всебічний моніторинг, діагностику та оцінку розвитку енергетичного ринку. Метою статті є аналіз тенденцій розвитку підприємств енергетичної галузі і оптимізація атомної енергії в Україні на засадах екомаркетингу для підвищення безпеки у майбутньому. Для досягнення поставленої мети  проаналізовано ринок електроенергії України, його тенденції та перспективи розвитку. Проведено дослідження ТОП-20 країн, що найбільше виробляють електроенергію в Європі. В статті проаналізовано стан ядерної енергетики в Україні та світі. Здійснено стратегічний аналіз атомної енергії та її оптимізації в Україні на засадах екомаркетингу. Зазначено, що бізнес в елетроенергетиці прогнозуючі свою діяльність і розробляючі програму свого перспективного розвитку  повинен вивчати досвід конкурентів та попит на електроенергію загалом і за окремими сегментами ринку. Запропоновано орієнтуватися на споживача — розуміти дійсні та майбутні  їх потреби, намагатися перевершити їхні очікування. Адже важливо розробити і вибрати правильну маркетингову стратегію, виявити, сформувати і задовольнити потреби споживачів. Соціальна відповідальність стає ключовим чинником налагодження дієвого діалогу між бізнесом, урядом та суспільством. Прагнення інтегруватись у європейські і світові економічні структури вимагає засвоєння нових правил поведінки в умовах нестабільного середовища. Наразі необхідно  впроваджувати найновіші технології і мати найнижчі ціни та найвищі орієнтири стосовно найвимогливішого споживача. Дотримання принципів соціальної відповідальності дозволять підприємствам зайняти лідируючі позиції. Зроблено висновок про те, що енергетична стратегія України і нова економічна модель до 2050 р. передбачає відновлення енергетичної генерації. Підвищення якості життя — основа державної політики розвинених країн.  Автором вперше оптимізовано обсяги атомної енергії в Україні на рівні 10,3% до 2050 р. згідно Енергетичної стратегії України та відновлювальних джерел енергії, які надшвидко розвиваються.
A CIDADE E O ROMANCE: FORTALEZA LITERÁRIA EM A NORMALISTA, DE ADOLFO CAMINHA
Authors: Guerra Tais Teixeira , Cavalcante Tiago Vieira
Published: October 2024

Este trabalho tem o propósito de apresentar a cidade de Fortaleza do século XIX a partir de uma interpretação geográfico-literária da obra A Normalista, do escritor cearense Adolfo Caminha (1867-1897). Para isso, com base na Geografia Humanista, abordagem que valoriza a visão de mundo das pessoas, refletida na valorização do lugar, como objeto de estudo privilegiado, passeamos por temas como polí­tica, educação, seca, modernização, cotidiano, entre outros, colocando em relevo, por meio da obra literária, alguns assuntos caros à Geografia. Como modo de entender a cidade do passado a partir de rastros do presente, uma trilha urbana foi também elaborada a fim de acompanhar alguns dos passos das personagens da obra em questão. Na trilha, é possí­vel dialogar tanto com a paisagem como com a literatura, e perceber a cidade por múltiplos olhares. Este trabalho, enfim, procura ampliar o horizonte de uma Fortaleza Literária possí­vel, existente na criação literária e nos percursos que produz, enriquecendo a nossa compreensão da cidade em sua espacialidade, geograficidade e historicidade.
Tác động của đầu tư công, đầu tư tư nhân tới tăng trưởng kinh tế vùng Bắc Trung Bộ
Authors: Trần Thị Hồng Lam
Published: October 2024

Trong bối cảnh cách mạng công nghiệp 4.0 và thu hút sự quan tâm của các nhà đầu tư quốc tế, Vùng Bắc Trung Bộ đang nỗ lực tối ưu hóa các nguồn lực đầu tư nhằm mục tiêu phát triển bền vững và đồng đều. Nghiên cứu này làm rõ tác động của đầu tư công và đầu tư tư nhân tới tăng trưởng kinh tế của Vùng Bắc trung Bộ. Bài viết sử dụng nhiều phương pháp ước lượng khác nhau như OLS, FEM, 3SLS và ARDL với số liệu thứ cấp từ niên giám thống kê của các tỉnh Vùng BTB trong giai đoạn 2010- 2023. Kết quả cho thấy đầu tư công và đầu tư tư nhân đều có tác động tích cực tới tăng trưởng kinh tế trong ngắn hạn và dài hạn. Ngoài ra, các yếu tố như lao động và vốn con người cũng có ảnh hưởng đến tăng trưởng kinh tế Vùng Bắc Trung Bộ. Từ kết quả phân tích, tác giả đề xuất một số hàm ý chính sách quan trọng nhằm thúc đẩy sự phát triển kinh tế bền vững tại Vùng Bắc Trung Bộ.
Clinical Database of Upper Gastrointestinal Cancer -A Window to the Real World
Authors:   , Wang Jingpu
Published: October 2024

Patient characteristics, tumor characteristics, treatment-related information, and treatment outcomes are the main types of data currently collected by clinical databases on upper gastrointestinal cancer in the Netherlands. These data comprehensively cover the information that medical professionals are concerned with before and after patient treatment. It may help clinicians and policymakers understand the characteristics of the patient populations in the real world, the treatments they receive, and their treatment outcomes. Furthermore, it can aid medical experts in making targeted interventions in real-world medical practices, ultimately helping to improve the prognosis of upper gastrointestinal cancer patients. In Part I, the experience of the DUCA database in registering and maintaining a high-quality upper gastrointestinal cancer clinical database over the past decade was evaluated, with the intention of providing a reference for the construction of clinical databases in other countries or populations. In Part II, the upper gastrointestinal cancer clinical databases were used to generate evidence that may improve cancer care management in the real world. In Part III, the upper gastrointestinal cancer clinical databases were used to generate evidence that may influence surgeons' treatment decisions.
Overcoming the Challenges of Increasing Urbanisation in Respiratory Health
Authors: Bradbury Helena
Published: October 2024

IN THIS year’s European Respiratory Society (ERS) Congress, a session
focused on the current challenges related to the impact of urbanisation on
respiratory health. This discussion among experts highlighted the role of environmental
factors, including air quality, green spaces, and indoor microbiomes, in shaping longterm
health outcomes.
The Future of Lung Transplantation in Cystic Fibrosis
Authors: Zurowska Aleksandra
Published: October 2024

AN INSIGHTFUL session on the future of lung transplantation presented at
this year’s European Respiratory Society (ERS) Congress explored the insights
shared by experts during sessions on lung transplantation, the role of machine learning
in cystic fibrosis care, and the future challenges ahead.
Review of the European Respiratory Society (ERS) Congress 2024
Authors: EMJ EMJ
Published: October 2024

WITH an impressive 34,000 members, attendees from more than 160
countries worldwide, and a record number of early career members,
the European Respiratory Society (ERS) Congress 2024 was one to be
remembered. Taking place in the vibrant and historical Vienna, Austria,
from 7th–11th September, the Congress featured dozens of symposia,
lectures, abstract presentations, and scientific posters from experts in
the field, discussing all of the hottest topics in respiratory medicine, as
well as the latest breaking research into chronic obstructive pulmonary
disease (COPD), bronchiectasis, and much more.
When Is a Dingo Not a Dingo?
Authors: Hillier Jean
Published: October 2024

In 2019 the Western Australian government recategorised the dingo ( Canis dingo) as a wild dog ( Canis familiaris) whose status is legally declared to be a pest. Despite its iconic native status, Canis dingo has been rendered non-existent and liable to be disposed of by inhumane means. Dumped in a legal black hole via a signifying regime of signs, dingoes are confronted with the fact of their own non-existence. Regarding the dingo as a dingoing, a multiplicity and a process, rather than a characteristic, I read the reclassification event symptomatologically and interrogate the constellations of symptoms and regimes of signs which legitimate the event and its performativity. I examine order-words including ‘pest’ and ‘wild dog’ to shift the focus from the words’ meaning to what they do. I subsequently enquire whether ‘dingo’ might become a pass-word, a component of passage, such that dingoes might exist under reprieve in a post-signifying regime. I argue that post-signifying regimes are codified, however, as subjects are individuated along lines of subjectification. I conclude by contemplating whether it is possible to break with subjectification, liberating these demonic nonhuman animals from the signifiers which territorialise them and permitting dingoes to become-animal.
Adapting (to) Jane Eyre: Racial Violence, Intergenerational Trauma, and Black Optimism in Lauren Blackwood’s Within These Wicked Walls
Authors: Dobbins Meg
Published: October 2024

This article draws on Fred Moten, Saidiya Hartman, and Christina Sharpe’s writings on ‘optimism,’ ‘wake work,’ and ‘fugitivity’ to present a reading of Lauren Blackwood’s 2021 rewriting of Charlotte Brontë's Jane Eyre as a metafiction of Black literary adaptation as survival. In rejecting the overdetermined stereotype of the mad subaltern woman as the localised focus of the novel’s commentary on racial violence, Within These Wicked Walls departs from twentieth-century, postcolonial responses to Jane Eyre exemplified by Gayatri Spivak’s reading of Wide Sargasso Sea to offer an explicitly Black and anti-racist rewriting of the Victorian novel. I show how Blackwood draws on the diasporic discourse of “Ethiopianism” and American genres of multiethnic and Black Gothic storytelling to explore the trauma of racialised violence (including its imperialist literature) as a cultural and intergenerational curse that must be faced, exorcised, and grieved by a younger generation. This analysis highlights the contributions Blackwood’s novel makes to the Black radical tradition, underscores the need for more Critical Race Theory in the study of Victorian literature, and reminds scholars of the vital role literary adaptation once played – and should still play – in criticism of race and imperialism in Victorian literature.
Many Caring Marys: Feminised Care in Mary Seacole’s Wonderful Adventures and Jackie Sibblies Drury’s Marys Seacole
Authors: Coons Jayda
Published: October 2024

Drawing upon a growing body of research in feminist care theory, this essay argues that Mary Seacole’s representation of care in her 1857 autobiography, Wonderful Adventures of Mrs. Seacole in Many Lands, uses maternal rhetoric to reinforce a Victorian vision of care grounded in feminine hospitality and domestic comfort. The essay considers Seacole’s narrative as both a sentimentalist story that sanitises care labour through her use of the figurative ‘mother,’ and as a testimony to the centrality of care labour, so often invisibilised, in grand narratives of history. I analyse this vision alongside Jackie Sibblies Drury’s 2019 play Marys Seacole, which reconsiders Seacole’s legacy by arguing instead for an entangled, interdependent model of care relations that explicitly attends to differences in class and race. Drury’s play ambivalently explores what is both inspiring and fraught within Seacole’s original narrative; its final dramatic thrust, which finds its characters clinging to the iconography of ‘Mother Seacole’ while physically clutching onto one another, registers the inadequacy of a care model dependent upon exploited mother figures and suggests the need for lateral, multiracial, and multigenerational networks of mutual support.
Bourbachokátzouli: A Greek Governess in Victorian England
Authors: Georganta Konstantina
Published: October 2024

In Victorian fiction, the Greek woman often appears as a representation of modern Greece, with the 1821 War of Independence as a backdrop. When the novel A Modern Greek Heroine appeared in 1880, the Morning Post naturally noted that ‘this is not, as might possibly be supposed from its title, the biography of any champion of Hellenic independence, but a novel of English life’ (3). Henry Cresswell, the novel's author, imagined an alternative universe for his heroine. In A Modern Greek Heroine, Bourbachokátzouli has lost her father and connection to her homeland and is haunted not by the ghost of a lost cause but by a man suspected of insanity in a trajectory that brings her to Britain to seek employment as a governess. Cresswell drew inspiration from revolutionary Crete, giving his main protagonist the highly distinctive name of a real-life woman warrior from Sfakia, yet his Bourbachokátzouli is both an unconventional ‘modern Greek heroine’, resenting many elements of her Greek past, and an untypical Victorian governess harnessing the heroic in herself. Employed as a French governess in Britain and received as an untruthful Greek, she discovers heroism in self-abnegation, exposes late-Victorian society's limitations, subverts stereotypes, and finally finds herself in a position of power.
Cercanías y distancias en la política transnacional: el MAS-IPSP boliviano en Argentina en 2020
Authors: Rodrigo Federico
Published: October 2024

Este trabajo analiza la conformación del MAS-IPSP en Argentina y el impacto en su militancia de la llegada de dirigentes de máxima relevancia de ese partido luego de la renuncia de Evo Morales a la presidencia de Bolivia en noviembre de 2019. Por medio de observaciones participantes y entrevistas, se reconoce que la proximidad experimentada entre los/as activistas de la diáspora y los/as referentes partidarios es una dimensión relevante de este proceso. En particular, se encuentra que la cercanía no solo favoreció la simultaneidad en la pertenencia y la participación de los/as migrantes en los campos políticos de ambos países, sino que potenció su interpenetración. De esta manera, la originalidad del trabajo está dada por la identificación de un factor decisivo en la conformación y en el desarrollo de los colectivos políticos transnacionales y sus formas de funcionamiento poco tratado por la bibliografía.
DA GÊNESE À INSTITUCIONALIZAÇÃO DO COLETIVISMO ARTÍSTICO BRASILEIRO
Authors: Eboli Nogueira Pedro Caetano
Published: October 2024

O presente artigo inicialmente remonta à primeira década dos anos 2000, para discutir a gênese do coletivismo artístico e ativista no Brasil, enquanto forma de coletividade distinta dos grupos. Neste bojo, sublinhamos os modos pelos quais estes coletivos exercem uma relação crítica com as instituições de arte. Em seguida, abordamos a maneira como a exposição Zona de Poesia Árida, realizada em 2015 no Museu de Arte do Rio, reencena uma série de querelas em torno do processo de institucionalização e historicização destes coletivos nos circuitos de arte contemporânea. Partindo dos subsídios teóricos de Cristina Freire, Lucy Lippard, Jacques Rancière e Peter Bürger, explicitamos de que forma as discussões que ganham corpo nesta exposição partem de uma relação simplista entre arte e práxis vital, em que a eficácia política depende de uma saída dos espaços da arte. Por fim, propomos a institucionalidade crítica como modo de manter, em tensionamento, certo campo de contaminações entre arte, não-arte, ativismo e política.
CARRINHO VAZIO
Authors: Lins Nina
Published: October 2024

A partir de anúncios de venda de souvenir da obra Vênus de Milo, encontrados em sites como Amazon, Aliexpress, Shopee, entre outros, foi desenvolvida uma série de cartazes em serigrafia em formato 66 x 96 cm. Fragmentos de Vênus em souvenir misturam-se com fragmentos de propaganda repetidos, em que nada se completa, como uma cacofonia, um excesso de informação, que beira o esvaziamento de significado das imagens. A partir da fragmentação, este ensaio é um exercício de desgaste e explosão de códigos, como o significado da Vênus de Milo, enquanto obra de arte icônica, ideais de beleza e harmonia, e seu valor histórico e comercial.
FORMA OBJETIVA
Authors: Martins Luiz Renato
Published: October 2024

Nos debates sobre a modernização periférica tardia, Roberto Schwarz estabeleceu a forma objetiva (1991) como constructo que fornece os elos rítmicos e invisíveis entre o domínio sócio-histórico e o estético. Ela consiste, segundo Schwarz, numa forma que compreende "uma substância prático-histórica" (1991), ou, como diria depois, que atua como o "nervo social da forma de arte" (1997). Ao conectar a experiência social preexistente e a forma esteticamente construída, a forma objetiva vale como um contrato social, legitimando a forma estética. Encomendado social e historicamente por um sujeito coletivo e impessoal, tal constructo distingue-se do ecletismo pós-moderno desconectado do processo histórico. A forma objetiva oferece inteligibilidade crítica ante a matéria histórico-social apenas se, e quando, tomada como forma intrínseca à esfera estética; vale dizer, noutros termos, que o problema da condensação estética dos ritmos sociais repõe-se concreta e incessantemente – na produção e recepção – sempre que necessário retraçar os elos recíprocos entre as formas artísticas e as sócio-históricas. Desse modo, o exercício da intuição estética e da reflexão crítica, em interação com os materiais artísticos, é crucial à objetivação e à explicitação da síntese com a matéria sócio-histórica – do contrário, inapreensível nas conexões intrínsecas da percepção e da reflexão com a objetividade e a dinâmica históricas. Há coisas, em suma, que apenas na arte emergem e a tornam ferramenta indispensável à reflexão histórica dialética. Nesse sentido, este trabalho busca revisitar certas respostas críticas que a arte e a arquitetura brasileiras (Antonio Dias, Amilcar de Castro e Mendes da Rocha) deram ao golpe civil-militar de 1964 e à modernização tardia acelerada a seguir. E, por fim, reexamina também a instalação contemporânea Roda Gigante (2019, Carmela Gross) – um constructo arquitetônico negativo que totalizou o trágico momento brasileiro, sob domínio da ultradireita, com rara clareza e pungência épica.
NOTAS PARA PENSAR AS CRISES AMBIENTAIS A PARTIR DO MUNDO COLONIAL E DA ARTE CONTEMPORÂNEA
Authors: Bulhões Maria Amelia
Published: October 2024

Resumo: Frente à emergência das crises climáticas e perspectivas de fim de mundo exploradas por muitos autores, este artigo parte das discussões propostas por Malcom Ferdinand e Ticio Escobar para pensar nas consequências da colonialidade e suas reverberações na arte contemporânea. Enquanto Ferdinand desenvolve o conceito de ecologia decolonial, Escobar explora a noção de aura latente, podendo ideias serem consideradas como atualizações das teorias marxistas a partir do mundo colonial. Neste texto, e partir das teorias desenvolvidas por ambos, destaco obras dos artistas visuais Grada Kilomba, Ayrson Herácito, Daiara Tukano e  Glicéria Tupinambá, que se estabelecem como práticas artísticas contracoloniais, dialogando com os conceitos e reflexões desenvolvidos por estes autores
ATIVAR A IMAGINAÇÃO CRÍTICA EM TORNO DOS SIGNOS
Authors: Ribeiro Cavalcanti Raíza
Published: October 2024

Neste texto, Nelly Richard realiza uma análise crítica da obra de Lotty Rosenfeld, enfatizando o período das décadas de 1970 a 1980 de produção da artista. A partir da elaboração de núcleos de análise, Richard conecta diferentes trabalhos, dos mais icônicos aos menos conhecidos, traçando a partir  dos distintos contextos e formatos de cada um, seus sentidos compartilhados. Durante o ensaio, Richard elabora uma profunda reflexão sobre a trajetória artística de Lotty Rosenfeld, enfatizando tanto seu período como parte do movimento de arte avançada chileno (durante sua participação no Grupo CADA), como a sua participação política no movimento feminista “Mujeres por la Vida”, encontrando no político a linha que conecta a trajetória de vida e artística de Rosenfeld. Este texto foi publicado originalmente no catálogo "Lotty Rosenfeld: entrecruces de la memoria (1979-2020)”  da mostra retrospectiva de Lotty Rosenfeld - curada por Nelly Richard com investigação de Mariairis Flores- realizada no Museu Nacional de Bellas Artes (Santiago, Chile) em setembro de 2023, no contexto das comemorações dos cinquenta anos do golpe de estado de 1973. A reprodução deste texto foi autorizada pela autora e conta com a tradução de Raíza Cavalcanti.
Improving Biomedical Science Literacy and Patient-Directed Knowledge of Tuberculosis (TB): A Cross-Sectional Infodemiology Study Examining Readability of Patient-Facing TB Information
Authors: Shannon Caoimhe , Millar Beverley C. , Moore John E.
Published: October 2024

Background

Tuberculosis (TB) continues be the leading cause of death globally due to an infectious agent. There is a paucity of data describing the readability of patient-facing TB information for service users. The aim of this study was to calculate the readability of multiple global TB information sources.

Methods

Information on tuberculosis (n = 150 sources) included nine categories, Patient-facing information: WHO publications (n = 17), International governments (n = 19), Hospitals (n = 10), Non-government organisations (NGOs)/charities (n = 20), Cochrane Plain Language Summaries (n = 20); LabTestsOnlineUK (n = 4) and Scientific-facing information: Clinical trials (n = 20), Cochrane abstracts (n = 20), Scientific abstracts (n = 20). Readability was calculated using Readable software, defined by (i) Flesch Reading Ease (FRE), (ii) Flesch-Kincaid Grade Level (FKGL), (iii) Gunning Fog Index and (iv) SMOG Index and two text metrics [words/sentence, syllables/word].

Results

Mean readability values for TB information for the FRE and FKGL were 35.6 ± 1.6 (standard error of mean (SEM)) (US Target ≥60; UK Target ≥90) and 12.3 ± 0.3 (US Target ≤8; UK Target ≤6), respectively, with mean words per sentence and syllables per word of 17.2 and 1.8, respectively. Cochrane Plain Language Summaries had similar readability scores to their matching scientific abstract (p = 0.15). LabTestsOnlineUK yielded a mean FRE score of 51.5 ± 1.2, a mean FKGL score of 10.2 ± 0.5 and text metric scores of 16.7 ± 2.3 and 1.6, for words per sentence and syllables per word, respectively. In descending order, TB information from international governments, hospitals and LabTestsOnlineUK were the most readable (FRE = 57.9, 54.1 and 51.5, respectively), whereas scientific abstracts and Cochrane abstracts were the most difficult to read (13.0 and 30.2, respectively).

Conclusion

Patient-facing TB information analysed had poor readability. Effective communication of biomedical science concepts and information relating to TB is vital for service users to enhance their health literacy of tuberculosis, thereby promoting better clinical outcomes. Biomedical scientists are important custodians of scientific information for their service user populations, including other healthcare professionals within the TB multidisciplinary (MDT) team and patient service users. When preparing TB information, this should be checked and modified in real time employing readability calculators, to align with health readability targets.
Functionality of lyophilized osteoinductive EVs: a mechanistic study
Authors: Huang Chun-Chieh , Kang Miya , Debnath Koushik , Leung Kasey , Raghavan Vidhath , Lu Yu , Cooper Lyndon F. , Gajendrareddy Praveen , Ravindran Sriram
Published: October 2024

Introduction

Mesenchymal stem cell-derived extracellular vesicles (MSC EVs) hold significant promise for regenerative medicine. Lyophilization of EVs significantly enhances their translational potential. While, lyophilized EVs have been studied from a morphological perspective, the functional stability of these EVs and their cargo following lyophilization need to be mechanistically investigated.

Methods

In this study, we investigated the functional and mechanistic bioactivity of fresh versus lyophilized MSC EVs, specifically focusing on functionally engineered osteoinductive EVs developed in our laboratory. We utilized dimethyl sulfoxide (DMSO) as a cryoprotectant and conducted pathway-specific in vitro and in vivo experiments to assess the stability and functionality of the EVs.

Results

Our findings show that using DMSO as a cryoprotectant before lyophilization preserves the functional stability of engineered MSC EVs. In vitro experiments demonstrated that the endocytosis, cargo integrity, and pathway-specific activity of lyophilized EVs were maintained when DMSO was used as the cryoprotectant. Additionally, in vivo bone regeneration studies revealed that the functionality of cryoprotected lyophilized EVs was comparable to that of freshly isolated EVs.

Discussion

These results provide a foundation for evaluating the functionality of lyophilized EVs and exploring the use of DMSO and other cryoprotectants in EV-based therapies. Understanding the functionality of lyophilized naïve and engineered EVs from a mechanistic perspective may enhance validation approaches for tissue regeneration strategies.
The role of IL-17 family cytokines in cardiac fibrosis
Authors: Huang Liqing
Published: October 2024

Myocardial fibrosis is a common pathological feature in various cardiovascular diseases including myocardial infarction, heart failure, and myocarditis. Generally, persistent myocardial fibrosis correlates with poor prognosis and ranks among the leading causes of death globally. Currently, there is no effective treatment for myocardial fibrosis, partly due to its unclear pathogenic mechanism. Increasing studies have shown IL-17 family cytokines are strongly associated with the initiation and propagation of myocardial fibrosis. This review summarizes the expression, action, and signal transduction mechanisms of IL-17, focusing on its role in fibrosis associated with cardiovascular diseases such as myocardial infarction, heart failure, hypertension, diabetes, and myocarditis. It also discusses its potential as a therapeutic target, offering new insights for the clinical treatment of myocardial fibrosis.
Single-cell multiomics: a new frontier in drug research and development
Authors: Ma Jiaxiu , Dong Chao , He Aibin , Xiong Haiqing
Published: October 2024

Single-cell multiomics (sc-multiomics) is a burgeoning field that simultaneously integrates multiple layers of molecular information, enabling the characterization of dynamic cell states and activities in development and disease as well as treatment response. Studying drug actions and responses using sc-multiomics technologies has revolutionized our understanding of how small molecules intervene for specific cell types in cancer treatment and how they are linked with disease etiology and progression. Here, we summarize recent advances in sc-multiomics technologies that have been adapted and improved in drug research and development, with a focus on genome-wide examination of drug-chromatin engagement and the applications in drug response and the mechanisms of drug resistance. Furthermore, we discuss how state-of-the-art technologies can be taken forward to devise innovative personalized treatment modalities in biomedical research.
Online learning experiences of female students living with albinism amidst a global pandemic: evidence from South Africa and Zimbabwe
Authors: Makura Alfred H. , Zireva Davison
Published: October 2024

Our paper explores the online learning experiences of two female students living with albinism in South Africa and Zimbabwe during the COVID-19 era. Using a two-case qualitative research design, we conducted in-depth face to face interviews with the purposefully selected sample. The intention was to bring to the fore, the unique online experiences of female students living with albinism. Data were thematically analyzed. Literature suggests that the unique health and physiological characteristics of students living with albinism tend to present unique but surmountable challenges. Our study established that the gender and physiology of the students tended to complicate or enhance their desire to benefit from online learning during the COVID-19 era. The findings make a case for academic inclusion in universities’ academic projects. Institutions May consider instituting pedagogically inclusive online learning mechanisms that are not only gender sensitive, but are in sync with, not only the COVID-19 realities, but similar calamities.
Causal relationships of familial hypercholesterolemia with the risk of multiple vitamin deficiencies: a Mendelian randomization study
Authors: Zhang Cheng , Wei Gang , Zhou Huan , Liu Lin
Published: October 2024

Background

The causal relationship between familial hypercholesterolemia (FH) and various vitamin deficiencies has not yet been elucidated. Therefore, this study investigated the cause-and-effect relationship between FH and the risk of multiple vitamin deficiencies in humans.

Methods

Mendelian randomization (MR) analysis was performed by extracting six datasets for FH, FH with ischemic heart disease (IHD), and vitamin deficiency (vitamin A, thiamine, other B-group vitamins, and vitamin D) from the FinnGen study, covering a total of 329,115; 316,290; 354,932; 354,949; 355,411 and 355,238 individuals, respectively.

Results

FH was suggestively associated with higher odds of thiamine deficiency [inverse variance weighted odds ratio (ORIVW) 95% confidence interval (CI): 1.62 (1.03, 2.55), P = 0.036] and vitamin D deficiencies [ORIVW CI: 1.35 (1.04, 1.75), P = 0.024], low-density lipoprotein receptor (LDLR) rs112898275 variant, rs11591147 and rs499883 in proprotein convertase subtilisin/kexin 9 (PCSK9), rs9644862 in cyclin-dependent kinase inhibitor 2 B antisense RNA1 (CDKN2B-AS1), and rs142834163 in dedicator of cytokinesis 6 (DOCK6) and rs115478735 in ABO blood group (ABO) strongly influenced the risk of thiamine deficiency, while the rs7412 variant in apolipoprotein E (APOE) mostly influenced the risk of vitamin D deficiency. FH with IHD was suggestively associated with higher odds of vitamin D deficiency (ORIVW, weighted median [WM][95%CI]: 1.31 [1.05, 1.64]; 1.47 [1.10, 1.97]) (P = 0.018; 0.010) without any single significant SNPs observed.

Conclusion

FH was positively associated with increased risks of thiamine and vitamin D deficiencies, revealing a prospective and unfortunate complication of FH.
Analysis of risk factors for painful diabetic peripheral neuropathy and construction of a prediction model based on Lasso regression
Authors: Yu Zikai , Zhao Sue , Cao Jing , Xie Hebin
Published: October 2024

Objective

To evaluate the prevalence and risk factors of painful diabetic peripheral neuropathy (PDPN) in patients with type 2 diabetic peripheral neuropathy (DPN) in Hunan Province, and establish and verify the prediction model.

Methods

This was a retrospective study involving 4908 patients, all patients were randomly divided into the training dataset(3436 cases)and the validation dataset (1472 cases) in a ratio of 7:3. Electroneurogram, clinical signs,and symptoms were used to evaluate neuropathy. Least absolute shrinkage and selection operator (LASSO) regression was used to select the optimal factors, and multifactorial logistic regression analysis was used to build a clinical prediction model. Calibration plots, decision curve analysis (DCA), and subject work characteristic curves (ROC) were used to assess the predictive effects.

Result

The prevalence of PDPN was 33.2%, and the multivariate logistic regression model showed that peripheral artery disease, duration of diabetes, smoking, and HBA1c were independent risk factors for PDPN in patients with type 2 diabetes. ROC analysis results showed that the AUC of the established prediction model was 0.872 in the training dataset and 0.843 in the validation dataset. The calibration curve and decision curve show that the model has good consistency and significant net benefit.

Conclusion

33.2% of DPN patients had PDPN in Hunan Province, China. Peripheral artery disease, duration of diabetes, smoking, and HBA1c are risk factors for PDPN in patients with type 2 diabetes. The prediction model is based on the above factors, which can well predict the probability of PDPN.
Extracting metal oxide redox thermodynamics from TGA measurements requires moving beyond the linearized van ‘t Hoff approach
Authors: Wilson Steven A. , Sarsam Paul W. , Stechel Ellen B. , Muhich Christopher L.
Published: October 2024

Thermodynamic modeling of metal oxide reduction is crucial for optimizing chemical processes and materials in systems dependent on off-stoichiometric reduction/re-oxidation cycling. Two prevalent methods for extracting reduction thermodynamics from thermogravimetric data are linearized van ‘t Hoff (VH) analysis and the compound energy formalism (CEF). This work evaluates the accuracy of these methods by constructing invertible ground truth thermodynamic models, generating hypothetical thermogravimetric data, and determining the reduction thermodynamic using both VH and CEF methods. Our findings reveal that the VH method produces absolute errors 3–5 times higher than the CEF in kJ/mol O or J/mol O K for enthalpy and entropy of reduction, respectively. In contrast, the CrossFit CEF (CF-CEF) method yields errors often less than 10 kJ/mol O or J/mol O K. Moreover, the CF-CEF method provides models based on mole fraction, temperature, and extent of reduction, while a typical VH analysis provides thermodynamics of only the specific compositions measured. Although simple to implement, the VH method suffers from significant, non-systematic errors due to entropy/enthalpy compensation and defect modeling. Consequently, we recommend the more complex but robust, CF-CEF method for extracting redox thermodynamics from thermogravimetric measurements.