bluuebunny/crossref_metadata_2025 huggingface dataset:
Ecolinguistic study on environmental discourse in senior high school (MA/SMA) Indonesian textbook
Authors: Putra Dona Aji Karunia
Published: July 2024

Ecolinguistics is a study of the impact of the use of language on the survival that connects humans, other organisms, and the physical environment that is normatively oriented towards preserving relationships and sustainable life. Ecolinguistics can be used as an approach to teach Indonesian as a second language for Indonesians. With an ecolinguistic approach, students are expected to be able to learn Indonesian to represent nature or the environment they face on a daily basis. This study aims to describe the form, variation, and frequency of use of environmental discourse in Indonesian language textbooks for MA/SMA students. Furthermore, this research will specifically examine the form and function of linguistic features which include lexical and semantic aspects used in environmental discourse in Indonesian language textbooks for MA/SMA students. This study used descriptive qualitative method. The data in this study are in the form of sentences, phrases, words related to the field of ecology. The data were analyzed using ecolinguistic theoretical framework and supported by discourse theory, lexicon theory, and semantic theory. The results showed that the Indonesian Language textbooks Cerdas Berbahasa Indonesia for class X, XI, and XII written by Engkos Kosasih was still lacking in presenting discourses on environmental themes. The environmental lexicon inserted in the discourses of the textbooks Cerdas Berbahasa Indonesia for class X, XI, and XII written by Engkos Kosasih are more informative or tend to introduce general and specific terms related to the environment. The most dominant lexicon used to form the value or character of caring for the environment is the type of verb.
Perkembangan penelitian pembelajaran bahasa Indonesia sebagai bahasa kedua: Analisis bibliometrik
Authors: Prihatini Arti
Published: July 2024

Banyak penelitian tentang pembelajaran bahasa Indonesia sebagai bahasa kedua, tetapi masih belum banyak penelitian yang memetakan tren topik penelitian ini. Oleh karena itu, penelitian ini bertujuan untuk mendeskripsikan tren penelitian pembelajaran bahasa Indonesia sebagai bahasa kedua. Jenis penelitian ini adalah analisis bibliometrik. Instrumen pengumpulan data adalah aplikasi Publish or Perish untuk menjaring metadata dari Google Scholar pada 2013-2022. Analisis data dilakukan berdasarkan indikator kuantitas, kualitas, dan struktural dengan aplikasi VOSviewer. Temuan menunjukkan sembilan klaster penelitian, yaitu (1) pembelajaran bahasa Indonesia dan outcome, (2) pelajar bahasa Indonesia dan model pembelajaran, (3) pemerolehan bahasa, (4) analisis kesalahan berbahasa dan praktik berbahasa, (5) teknologi dan multimedia dalam pembelajaran, (6) kearifan lokal, (7) pembelajaran bahasa kedua selama pandemi, (8) penilaian autentik, dan (9) guru. Selama 2013—2016, jumlah publikasi mengalami naik-turun, sedangkan pada 2017 mengalami peningkatan hingga 2020. Tahun 2021 mengalami penurunan, tetapi 2022 meningkat. Kepadatan penelitian menunjukkan tren tentang pembelajaran bahasa kedua, guru, dan outcome. Model pembelajaran adalah topik yang paling populer berdasarkan artikel yang paling banyak disitasi. Jumlah co-authorship terbatas pada sembilan penulis saja. Jadi, dapat disimpulkan bahwa tren penelitian pembelajaran bahasa Indonesia sebagai bahasa kedua menunjukkan adanya dinamika dan perubahan, tetapi belum ada tren baru setelah tahun 2021.
Kurikulum berparadigma Wahdatul ‘Ulum pada Prodi Tadris Bahasa Indonesia Universitas Islam Negeri Sumatera Utara
Authors: Devianty Rina , Wahyuni Sri , Maisarah  , Sakulpimolrat Sirikanda
Published: July 2024

Kurikulum merupakan panduan pelaksanaan pengajaran sesuai visi misi program studi dan perkembangan IPTEK. Oleh karena itu, kurikulum harus senantiasa dikembangkan seperti arahan Kementerian Agama dan Rektor UINSU agar setiap prodi di lingkungan UINSU mengembangkan kurikulum berparadigma Wahdatul ‘Ulum. Namun Prodi Tadris Bahasa Indonesia UINSU masih menggunakan kurikulum KKNI tanpa menanamkan karakter Wahdatul ‘Ulum. Pada artikel ini dijelaskan mekanisme pengembangan kurikulum berparadigma Wahdatul ‘Ulum untuk Prodi Tadris Bahasa Indonesia, dan menganalisis kelayakannya. Penelitian pada artikel ini berjenis penelitian pengembangan. Teknik pengumpulan datanya menggunakan angket tertutup dan studi dokumen. Kemudian data dianalisis menggunakan uji persentase rerata skor. Hasil penelitian menunjukkan bahwa ahli desain kurikulum memberikan skor sebesar 92,63%, ahli materi Tadris Bahasa Indonesia memberikan skor sebesar 91,67%, ahli Wahdatul ‘Ulum memberikan skor sebesar 94,55%, dan skor rata-rata penilaian sebesar 92,95% atau berkategori sangat valid. Dari ketiga ahli validator sudah menyatakan bahwa kurikulum Tadris Bahasa Indonesia berparadigma Wahdatul ‘Ulum sangat layak untuk diterapkan dan tidak ada memberikan saran revisi atau perbaikan, sehingga tahapan validasi dicukupkan pada tahap kedua atau tahap akhir. Dengan demikian, pada penelitian ini telah dihasilkan produk berupa kurikulum prodi Tadris Bahasa Indonesia berparadigma Wahdatul ‘Ulum yang sangat layak diterapkan dan akan memberikan kontribusi terhadap profil dan karakter mahasiswa yang ‘ulul albab.
Tantangan dan Peluang Dalam Moderasi Beragama: Dinamika Kehidupan Beragama di Kelurahan Sedayu Jawa Timur
Authors: Fitri Madani Annisa , Salsabila Arini , Ghina Aisy Shintya , Dany Rahmat Rizafan
Published: July 2024

This study examines the dynamics of religious life in Sedayu District, as well as the opportunities and challenges of implementing religious moderation in everyday life. The aim of this research is to find out how religious moderation is carried out by residents of Sedayu District and what opportunities and challenges they face. The method used in this research is the research method used by researchers in this research is a qualitative approach with descriptive methods. The research method used is a qualitative method. Data collection technique. Data collection techniques in qualitative research include observation, interviews, and documentation studies. On the other hand, there are opportunities for religious moderation in Sedayu Village. The role of technology can be utilized to facilitate the religious practices of the Sedayu Village community. Technology can be used to facilitate access to religious information and facilitate religious activities. Apart from that, religious diversity can also be used as a source of strength in building social harmony in Sedayu Village. In facing the challenges and opportunities of religious moderation in Sedayu Village, there needs to be a joint commitment from all stakeholders. Challenges such as tensions between religions can be overcome through joint efforts to understand, respect, and accept religious diversity. On the other hand, these opportunities can be optimized through interfaith collaboration, inclusive religious education, and active community participation.
Reciting Surah al-Kahf in the Month of Ramadan: A Case Study of Live Streaming on Instagram by Dompet Dhuafa Community Media
Authors: Wahyuni Yuni
Published: July 2024

This article delves into the recitation of Surah al-Kahf on the live streaming Instagram account of the Dompet Dhuafa community during the Ramadan program. The practice of reading Surah al-Kahf is recommended as one of the Sunnah practices, particularly on Fridays, as established by the hadith of Prophet Muhammad. This phenomenon continues to evolve within society. The research adopts a library research approach and utilizes Stuart Hall's encoding-decoding theory to analyze the phenomenon of reading Surah al-Kahf. The aim is to assess the alignment of the intended message by the video producer with the message perceived by the audience. The research findings reveal two interpretative meanings, in accordance with Stuart Hall's theory of encoding. The first is the dominant position, where the informant advocates for the recitation of Surah al-Kahf as a Sunnah to be performed every Friday. The negotiated position, on the other hand, reflects the informant's belief that reading Surah al-Kahf is indeed a Friday Sunnah, but simultaneously holds a differing perspective. The intended message of the video producer, presenting the recitation of Surah al-Kahf during Ramadan through live Instagram streaming, effectively reaches the audience. This conclusion is drawn from the response of informants who incorporate the recitation of Surah al-Kahf as a regular practice on Fridays, extending beyond the month of Ramadan.
GUEST EDITORIAL: Faces of Precarity: Restructuring Care-mentality in Asia
Authors: Dwivedi Om Prakash , Malhotra Isha
Published: July 2024

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Aging, Alzheimer’s, and Precarity: Comprehending Vulnerabilities and Care Approach
Authors: Dey Debashrita , Tripathi Priyanka
Published: July 2024

Aging and late-life realities are significantly determined by the experience of impairments, which introduces vulnerabilities, potentially resulting in a sense of devaluation due to dependence and an increased likelihood of facing disadvantages or unmet needs. The requirement for care, evaluated through instances of age-entailed cognitive and functional limitations, underlines the vulnerability associated with later age. Examining aging through the interpretive lens of precarity aids in configuring what it means to live a marginalized life with disabling conditions in contexts related to care, assistance, and support. With epidemiological studies emphasizing the projected surge of Alzheimer’s in India, the intersectional paradigm of critical disability studies and precarity studies have proffered new approaches to interpret, produce, and narrativize knowledge related to age-specific diseases, their diagnosis, and their treatment. This paper focuses on examining how fictional deliberations - Anuradha Sharma Pujari’s Jalsobi: In the Shadow of Light (2018) and Avni Doshi’s Girl in White Cotton (2019) - configure precarity through the markers of frailty, vulnerability, and increased dependency in older Indian women with diminishing cognitive capacities. It engages with the experientiality of cumulative losses -memory, functionality, and agency during old age, attempting to create alternative discourses of care that can confront and respond to the underlying vulnerabilities of conditions like Alzheimer’s.
Revisão sistemática dos acordos transformativos utilizando dados da Scopus e Web of Science
Authors: Marques Gabriel Silveira , Oliveira Renan Rangel de
Published: July 2024

Os Acordos Transformativos têm impulsionado a Ciência Aberta, centralizando o financiamento para o Acesso Aberto. Este estudo analisa a implementação e impacto dos Acordos Transformativos por meio de uma revisão sistemática. Foi levantado um total de 56 documentos, onde foram feitas as primeiras análises nos objetivos, metodologias e termos observados. Os resultados revelam aumento nas publicações anuais, tendências de abordagens e clusters relacionados com a abordagem dos trabalhos. Desafios incluem elegibilidade e mudanças durante o contrato. Futuras análises abordarão a designação de acesso aberto, clusters e métricas expandidas, enriquecendo a compreensão dos Acordos Transformativos e do acesso aberto à ciência.
Custo de APC em periódicos Qualis análise por estrato e área de avaliação
Authors: Neubert Patricia da Silva , Canto Fábio Lorensi do , Pinto Adilson Luiz , Carvalho Segundo Washington Luís Ribeiro de
Published: July 2024

Identifica as médias das taxas de processamento de artigos (APC) nos periódicos avaliados no sistema Qualis (2017-2020). Foram extraídos dados de APC do OpenAlex a partir do ISSN das publicações, eliminando-se as duplicatas com base no identificador source_id do OpenAlex. O maior percentual de periódicos Qualis que cobram APC são do estrato A, conjunto este que possui a média de APC mais elevada. Há diferenças significativas nos valores cobrados por periódicos das diferentes áreas de avaliação, com taxas superiores em periódicos dos colégios de Ciências Exatas e inferiores para os de Humanidades.
Transição de periódicos para o acesso aberto com Article Processing Charges (APC) implicações no contexto do sul global
Authors: Gomes Graziela Barros , Maricato João de Melo , Costa Michelli Pereira da
Published: July 2024

O estudo examinou o impacto da transição de periódicos de acesso restrito para acesso aberto com cobrança de Article Processing Charges (APCs) e suas implicações para os países do Sul e do Norte Global. Destacou-se a preocupação com as disparidades na produção científica e no acesso ao conhecimento entre países desenvolvidos e em desenvolvimento. A pesquisa adotou uma abordagem qualiquantitativa, combinando métodos de pesquisa documental e levantamento de dados. Embora as APCs não tenham reduzido a participação dos países do Sul, a produção científica global aumentou, com um crescimento significativo do Norte Global. Os resultados sugerem um desequilíbrio persistente nas relações científicas globais, demandando uma análise mais abrangente e aprofundada para compreender plenamente as nuances do acesso aberto.
Retratações científicas no Brasil uma análise detalhada a partir da Retraction Database e Plataforma Lattes
Authors: Dias Thiago Magela Rodrigues , Dias Patrícia Mascarenhas , Carvalho Segundo Washington Luís Ribeiro de , Silva Jônatas Edison da , Dias Guilherme Mascarenhas
Published: July 2024

Este artigo aborda a análise de artigos brasileiros sujeitos a retratações, utilizando a base da Retraction Database e a Plataforma Lattes do CNPq. O estudo cruzou dados por meio dos DOIs dos artigos científicos do conjunto em análise, identificando autores, instituições, áreas de formação e a evolução temporal das retratações. Revelou-se um panorama abrangente das publicações retratadas no Brasil, proporcionando resultados importantes sobre como tem acontecido o processo de retratação de publicações científicas. Os resultados contribuem para a compreensão dos fatores associados a retratações e oferecem base para futuras investigações no cenário científico brasileiro.
La comprensión de conceptos estadísticos en la educación secundaria
Authors: Ocampo Castaño Adriana
Published: July 2024

Las competencias derivadas de las matemáticas tradicionales como la estadística, han cobrado un importante protagonismo los años recientes. El objetivo fundamental del presente artículo es analizar si el estudiante logra comprender los conceptos estadísticos en la formación secundaria. Para la investigación, se abordó el problema desde un enfoque cuantitativo de corte descriptivo, mediante la aplicación de uncuestionario a una muestra compuesta por 83 estudiantes del nivel secundario de colegios comerciales de la ciudad de Pereira. Los resultados finales, permitieron conocer que el 42,2% de los estudiantes tienen problemas para comprender conceptos relacionados con las medidas de dispersión, mientras que 54,2%tiene problemas con el cálculo de probabilidades. El estadístico Chi Cuadrado permite concluir que el nivel de dominio guarda relación con el colegio en el que se estudie (X2 =33,065; p=0,00).
Switching Costs and Market Power in Auditing: Evidence from a Structural Approach
Authors: Guo Qiang , Koch Christopher , Zhu Aiyong
Published: July 2024

This study provides novel evidence on the magnitude of switching costs in auditing. Using a discrete choice approach, we infer switching costs from clients’ audit firm choices. The demand estimation reveals that switching costs are significant and vary by direction, with the highest costs associated with switching from non-Big 4 to Big 4 audit firms. Counterfactual analyses of forced switches suggest that switching costs are substantial, ranging from 0.7 billion U.S. dollars (14.2 percent of audit fees) to 1.2 billion U.S. dollars (24.0 percent of audit fees) when aggregated across all clients. Counterfactual analyses of voluntary switching show that the audit market would become highly dynamic and more concentrated if switching costs were removed. Additionally, clients would gain consumer surplus of up to 306 million U.S. dollars (5.4 percent of audit fees) in such a scenario. Overall, our study documents the importance of switching costs for understanding audit market dynamics.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: M42; M48; L11; L84.
The miR-203/ZBTB20/MAFA Axis Orchestrates Pancreatic β-Cell Maturation and Identity During Weaning and Diabetes
Authors: Li Yating , Yang Yuqian , Sun Yi , He Lu , Zhao Lin , Sun Haoran , Chang Xiaoai , Liang Rui , Wang Shusen , Han Xiao , Zhu Yunxia
Published: July 2024

Maturation of postnatal β-cells is regulated in a cell-autonomous manner, and metabolically stressed β-cells regress to an immature state, ensuring defective β-cell function and the onset of type 2 diabetes. The molecular mechanisms connecting the nutritional transition to β-cell maturation remain largely unknown. Here, we report a mature form of miRNA (miR-203)/ZBTB20/MAFA regulatory axis that mediates the β-cell maturation process. We show that the level of the mature form of miRNA (miR-203) in β-cells changes during the nutritional transition and that miR-203 inhibits β-cell maturation at the neonatal stage and under high-fat diet conditions. Using single-cell RNA sequencing, we demonstrated that miR-203 elevation promoted the transition of immature β-cells into CgBHi endocrine cells while suppressing gene expressions associated with β-cell maturation in a ZBTB20/MAFA-dependent manner. ZBTB20 is an authentic target of miR-203 and transcriptionally upregulates MAFA expression. Manipulating the miR-203/ZBTB20/MAFA axis may therefore offer a novel strategy for boosting functional β-cell numbers to alleviate diabetes.

Article Highlights
Effects of surface roughness on the microstructure and mechanical properties of dissimilar sapphire/Invar36 alloy joints made by ultrashort pulsed laser micro-welding
Authors: Yang Meng , Jiang Qing , Zhang Xiang , Wu Ming , Zhang Tao , Pan Rui , Li Peng , Wang Sumei , Yang Jin
Published: July 2024

The ultrashort pulsed (USP) laser microwelding of sapphire/lnvar36 alloy controlled by the surface roughness of metal was investigated for the first time. The surface roughness (Sa) of Invar alloys gradually decreased from 0.944 to 0.029 μm from the prime surface to grounded and polished surface. However, the joint shear strength first increased and then decreased with the lowered Sa, the maximum shear strength reached 107.87 MPa at the Sa ∼ 0.131 μm. Compared to other surfaces with low Sa, the relatively high surface roughness enhanced the interfacial thermal deposition both spatially and temporally which in turn promoted the diffusion of interface elements and the formation of jagged mechanical interlocking structures. Therefore, the appropriate rough metal surface was beneficial for the enhancement of sapphire/metal dissimilar joints. This report is of great significance in simplifying the surface preparation process in the USP laser microwelding of transparent hard and brittle materials with metals, therefore promoting this technique from lab to industry.
A Mini-Review of Microplastics in Aquaculture: Sources, Toxicity, Countermeasures and Prospects
Authors: Ghanem Sara F
Published: July 2024

Plastic waste has become an environmental problem of global concern. Since microplastics (MP) are accumulated in all marine compartments due to direct emissions from the fragmentation or technosphere of macroplastic waste, they constitute a potential risk for aquatic organisms that ingest them as well as for humans through the consumption of fishery products. Data on the effects and damages that MP debris may exert on marine biota and marine food supply chains is scarce, hence, the study of microplastics impact in aquaculture has become a universal research hotspot. This review shed light an overview on sources of MP, their deleterious impact on marine environment, their toxicological effects on marine organisms by affecting their survival rate, growth, behavior and reproduction which ultimately will reduce the economic benefits of aquaculture. Moreover, the potential health risks that MP pose to human at multiple levels through aquaculture products consumption are also discussed. Strengthening aquaculture management, ecological interception and purification as well as improving fishing gear and packaging are considered to be effective removal strategies for controlling MP pollution. As practical measures, new remote sensing technology and portable MP monitoring system are two prospects known to be widely applied. Finally, the supervision of MP pollution in aquaculture must be established by enforcing rapid waste management policies and strengthening the construction of laws and regulations.
A PESQUISA-AÇÃO NA GESTÃO DE UM PERIÓDICO CIENTÍFICO DO IFSULDEMINAS
Authors: Carvalho João Francisco Sarno , Ferreira Hiran Nonato Macedo , Cavalcanti Washington Moreira , Barbosa Maria Clara Santos
Published: July 2024

Esse estudo teve como objetivo contextualizar o processo de reestruturação de um periódico científico multidisciplinar vinculado a uma Instituição Federal de Ensino brasileira localizada no estado de Minas Gerais. Para alcançar tal objetivo foi realizada uma pesquisa-ação de natureza qualitativa-descritiva. Os pesquisadores debruçaram-se sobre os dados da revista para criar um diagnóstico atual e, a partir desses achados, estruturar um plano de reestruturação da revista científica. Os resultados encontrados a partir da mostraram que o periódico passou por um processo de reestruturação de sua gestão que culminou na adoção de um novo sistema de submissões de trabalhos para a revista; houve também aumento do número de submissões de trabalhos, aumento da quantidade de visitas na página da revista e maior procura/interesse de pesquisadores de diferentes áreas do conhecimento com novas submissões registradas em diferentes campos do conhecimento, tais como: administração, engenharias, enfermagem, medicina e ciências humanas.
TANGGAPAN PERSEPTUAL GURU BAHASA INGGRIS DI SD SE-SURAKARTA TERHADAP KEBIJAKAN PELAKSANAAN MATA PELAJARAN BAHASA INGGRIS DI SEKOLAH DASAR
Authors: Kaltsum Honest Ummi
Published: July 2024

This qualitative descriptive study aims to describe how the perceptual response of teachers of English in primary schools towards the government policy related to the implementa- tion of English subjects in elementary school. Population of this research is English teachers at the elementary school in Surakarta and takes a sample of English teachers from primary schools in partnership with UMS PGSD as many as 20 teachers of English. Methods of data collection in this study using observations, interviews and documentation, and analysis with interactive analysis. In this research, the elementary teachers as research respondents divided into two groups of teachers who have educa- tional backgrounds of English and non-English language. These two groups, divided into four categories. The first category are teachers who have a background in English education with teaching experience less than or equal to ten years. The second category are teachers with educational background in English with teaching experience more than ten years. The third categoryare teachers with backgrounds non English with teach- ing experience less than ten years. The fourth category are teachers with backgrounds non English with teaching experience more than ten years. The findings found in per- ceptual response from the four categories of teachers, show that basically they compre- hend that the implementation of English subjects in elementary school is very impor- tant due to many reasons. The teachers agree toward the implementation of English subject at elementary school as long as it is conducted seriously and in a professional ways rather than as a additional curriculum.
Visualisasi Wisata Sejarah dan Religi di Dusun Pondok Wonolelo Menggunakan Story Map
Authors: Harpudiansyah Fauzan Iqbal , Azmi Ulul , Maharani Fadhilla Ajeng Putri
Published: July 2024

Dusun Pondok Wonolelo memiliki tujuan wisata yang beragam, yang memiliki keindahan alam ditambah dengan nilai warisan sejarah yang sangat berharga. Sejarah yang terkandung dalam tempat ini memiliki potensi luar biasa untuk dijadikan magnet wisata yang mampu diperkenalkan kepada berbagai lapisan masyarakat melalui alat bantu seperti peta cerita (story map). Penelitian ini memiliki tujuan visual yang jelas, yaitu menggambarkan secara konkret dan memberikan informasi tentang destinasi wisata bersejarah dan religi di Dusun Pondok Wonolelo kepada seluruh khalayak. Metode penelitian ini mencakup pendekatan studi literatur dan wawancara untuk menghimpun informasi tentang warisan sejarah Dusun Pondok Wonolelo. Di samping itu, dokumentasi langsung di lapangan menjadi elemen penting guna mendapatkan gambar-gambar yang mendukung penceritaan dalam bentuk story map. Peta dasar dari story map ini terdiri dari peta foto udara Dusun Pondok Wonolelo yang terintegrasi dengan citra satelit wilayah sekitarnya. Hasil dari upaya penelitian ini hadir dalam bentuk story map yang dirancang menggunakan platform StoryMap JS, menyajikan informasi rinci tentang lokasi-lokasi wisata yang memiliki nilai sejarah dan religi. Keterjangkauan story map ini dapat diakses melalui tautan bit.ly/StoryMapWonolelo. Secara keseluruhan, penelitian ini berkontribusi dalam memperkenalkan dengan lebih baik warisan bersejarah Dusun Pondok Wonolelo kepada masyarakat, sekaligus mempromosikan potensi wisata yang tak hanya unik tetapi juga sarat makna.
Mitigating Security Threats for Digital Twin Platform: A Systematic Review with Future Scope and Research Challenges
Authors: Lipsa Swati , Dash Ranjan Kumar , Cengiz Korhan
Published: July 2024

In Industry 4.0, the digital twin (DT) enables users to simulate future states and configurations for prediction, optimization, and estimation. Although the potential of digital twin technology has been demonstrated by its proliferation in traditional industrial sectors, including construction, manufacturing, transportation, supply chain, healthcare, and agriculture, the risks involved with their integration have frequently been overlooked. Moreover, as a digital approach, it is intuitive to believe it is susceptible to adversarial attacks. This issue necessitates research into the multitude of attacks that the digital twin may face. This study enumerates various probable operation-specific attacks against digital twin platforms. Also, a comprehensive review of different existing techniques has been carried out to combat these attacks. A comparison of these strategies is provided to shed light on their efficacy against various attacks. Finally, future directions and research issues are highlighted that will help researchers expand the digital twin platform.
The Idea of Progress in the Research of Russian Historians from the Late XIX – Early XX Century
Authors:   Amur State University, Prokazin Viktor V.
Published: July 2024

This article explores the perspectives of Russian historical thinkers from the late XIX – early XX century on the idea of progress and its heuristic potential. It acknowledges that the attitude towards the concept of progress and its role in historical understanding was contradictory: while some professional historians applied it in their explanations of world and national history, a significant part criticized it to varying degrees, ranging from mod-erate to radical rejection. This dual stance was often associated with broader positivist and anti-positivist theo-retical and methodological positions. In the case of a positive assessment, the application of ideas and theories of progress by scientists as tools for highlighting historical facts, grouping them, describing and explaining them in specific studies is considered. Conversely, historians who rejected the concept of progress are de-scribed as employing various forms of criticism – factual, logical, philosophical, and ethical.
Scientific Knowledge in Modern Society: From Objectivity to Objective Sociality
Authors: Grishechkina Natalia V. ,   Saratov State Medical University named after V.I. Razumovsky
Published: July 2024

The article addresses the issue of how scientific knowledge is socially conditioned, emphasizing a communica-tive approach to understanding its foundations. The reflection on the social underpinnings of science is ex-plored within the domain of social philosophy. Central to this exploration is the concept of transdisciplinarity, which characterizes the modern production of scientific knowledge as socially contingent. The traditional model of objective reality, inherent in classical science, is argued to be evolving towards an understanding of objective sociality. This shift acknowledges new models of sociality that underscore the diminishing role of subjectivity amidst increasing individualization. Key thinkers such as K. Knorr-Cetina, Z. Bauman, M. Castells, and G. Reingold are referenced to illustrate this transformation. Sociality is increasingly viewed as a hybrid construct resulting from the collaborative efforts of techno-cyber systems and living individuals. The article underscores the relevance of referencing medical practices to study transdisciplinarity. In medical contexts, biomedical technologies are integrated into the patient’s life world, serving as experimental grounds for testing the applica-tion standards of advanced technologies to address socio-humanitarian issues. Bioethics serves as an exam-ple of transdisciplinary knowledge, integrating philosophical, socio-philosophical, technical, and applied medi-cal perspectives to tackle specific patient-related challenges. In conclusion, the article underscores the dynamic interplay between scientific knowledge production and its societal contexts, advocating for a nuanced under-standing of how scientific objectivity intersects with and shapes modern social realities.
Improving the Efficiency of Securities Market Operations amid Economic Turbulence
Authors: Korotin Kirill V. ,   Nizhny Novgorod Institute of Management – Branch of the Russian Presidential Academy  of National Economy and Public Administration
Published: July 2024

The aim of this study is to delineate strategies for enhancing the operational efficiency of the securities market during periods of economic turbulence. The goal was achieved by solving several tasks: analyzing statistical data pertaining to securities market operations, identifying interrelationships and implications within the statisti-cal data, pinpointing extant issues directly linked to market functioning and regulation, and devising solutions to address these challenges. The paper uses methods of analysis and synthesis in the framework of studying statistical data from reliable sources, such as data from the Bank of Russia and others, as well as a historical method for the theoretical part of the study. Logical methods of cognition including deduction, induction, gener-alization, and analogy are employed to ascertain correlations between statistical data and economic phenom-ena. In formulating recommendations, methods such as hypothesis formulation and forecasting are utilized. The relevance of the work is underscored by the prevailing global economic instability and specific challenges facing the Russian economy, notably sanctions-related issues. In conditions of uncertainty, problems pertinent to the securities market assume heightened significance, magnified against the backdrop of broader economic challenges, necessitating a meticulous and nuanced approach.
Military-Political Analysis of Russia’s Security at the Present Stage of Its Development
Authors: Bolgov Nikolay V. ,   University of World Civilizations named after V.V. Zhirinovsky, Kopylov Alexander V. , Likhonosov Alexander G. ,   University of World Civilizations named after V.V. Zhirinovsky,   University of World Civilizations named after V.V. Zhirinovsky
Published: July 2024

The study analyzes the military-political situation at the current stage of Russia’s development, as well as its impact on military security. The transnational nature of military threats objectively necessitates the intensifica-tion of diplomatic efforts to develop cooperation between States in preventing and eliminating such threats and challenges, as well as the development of military-political cooperation in combating common threats. All this requires knowledge from government and military leaders – not only in the field of management theory, but also in the field of diplomacy, a deep understanding of the country’s military potential and the policy of strategic deterrence. The features of the negotiation processes, the role and place of Russia in ensuring national security are revealed. According to the results of the analysis, negative trends have been identified that require the elim-ination of factors at the international level at the current stage of development, influencing which it is possible to stabilize the aggravated contradictions taking into account new threats. This will contribute to the development of the national security system. Proposals are made on new approaches to the formation of an ideological uni-fication of society based on the principles of social justice, as well as the use of existing potential.
Novel prophylactic and therapeutic multi-epitope vaccine based on Ag85A, Ag85B, ESAT-6, and CFP-10 of Mycobacterium tuberculosis using an immunoinformatics approach
Authors: Nugraha Muhammad Fikri , Changestu Daniel Alexander , Ramadhan Rizky , Salsabila Tasya , Nurizati Arsila , Pratiwi Sari Eka , Ysrafil Ysrafil
Published: July 2024

Objectives: Current tuberculosis (TB) control strategies face limitations, such as low antibiotic treatment compliance and a rise in multidrug resistance. Furthermore, the lack of a safe and effective vaccine compounds these challenges. The limited efficacy of existing vaccines against TB underscores the urgency for innovative strategies, such as immunoinformatics. Consequently, this study aimed to design a targeted multi-epitope vaccine against TB infection utilizing an immunoinformatics approach.Methods: The multi-epitope vaccine targeted Ag85A, Ag85B, ESAT-6, and CFP-10 proteins. The design adopted various immunoinformatics tools for cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and linear B lymphocyte (LBL) epitope prediction, the assessment of vaccine characteristics, structure modeling, population coverage analysis, disulfide engineering, solubility prediction, molecular docking/dynamics with toll-like receptors (TLRs), codon optimization/cloning, and immune simulation.Results: The multi-epitope vaccine, which was assembled using 12 CTL, 25 HTL, and 21 LBL epitopes associated with CpG adjuvants, showed promising characteristics. The immunoinformatics analysis confirmed the antigenicity, immunogenicity, and lack of allergenicity. Physicochemical evaluations indicated that the proteins were stable, thermostable, hydrophilic, and highly soluble. Docking simulations suggested high-affinity binding to TLRs, including TLR2, TLR4, and TLR9. In silico immune simulation predicted strong T cell (cytokine release) and B cell (immunoglobulin release) responses.Conclusion: This immunoinformatics-designed multi-epitope vaccine targeting Ag85A, Ag85B, ESAT-6, and CFP-10 proteins showed promising characteristics in terms of stability, immunogenicity, antigenicity, solubility, and predicted induction of humoral and adaptive immune responses. This suggests its potential as a prophylactic and therapeutic vaccine against TB.
An Analysis of Hybrid Media Practices by Selected Malaysian Artists
Authors: Anak Michael Valerie ,   College of Creative Arts, Universiti Teknologi MARA, Kota Samarahan Campus, Sarawak, Malaysia, Abd Rahman Khairul Aidil Azlin , Michael Vanden , Mohd Razali Noraziah ,   Faculty of Design and Architecture, Universiti Putra Malaysia, Serdang, Selangor Malaysia,   School of Computing and Creative Media, University of Technology Sarawak, Malaysia,   College of Creative Arts, Universiti Teknologi MARA, Kota Samarahan Campus, Sarawak, Malaysia
Published: July 2024

Malaysian artists had begun to explore a variety of media and techniques in producing artwork. Through this creative process, the possibility of applying a multidisciplinary practice has enhanced the way of producing their concept of hybrid practice through hybrid media. The objective of this paper is to analyze the hybrid media in hybrid art practice among selected Malaysian artists. The methodologies applied in this research were the questionnaires and interviews with selected artists which was highlighting their perceptions about the hybrid media based on their artwork. The researcher distributed questionnaires to 35 selected artists who had experience in producing hybrid artwork. The data was analyzed using descriptive analysis and principal component analysis (PCA). The result of the descriptive analysis shows that the experiment, new knowledge, strength, and combination are important elements in hybrid media in the practice of hybrid art. Meanwhile, the result of PCA for the evaluation of hybrid media stated that ideation, media knowledge, and applied collaboration were practiced by the selected Malaysian artists. The interview result explained the artist’s reflection on the result of the questionnaire.
Adaptation For Islamic Animation Storytelling: The Rhetorical Approach of Al-Mau’izah Al-Hasanah in Tafseer Al-Azhar
Authors: Mohd Muzamli Nurul Iva ,   College of Creative Arts, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia, Abdul Razak Mohamed Razeef ,   Islamic Research in Art, Design & Humanities (IRADAH) Research Group, College of Creative Arts,Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia
Published: July 2024

Al-Mau’izah Al-Hasanah is among the three Islamic Da’wah Methods that uses rhetorical strategies in da’wah dissemination. The method is based on Surah An-Nahl verse 125 in the Qur’an. As the verses of the Qur’an uses an Arabic text, Muslim need to use Tafseer as a guideline to enhance their understanding and knowledge of Islamic teaching. This is because not all Muslims are specialists in the Arabic language, despite being able to read the Quran in Arabic. Tafseer Al-Azhar is an interpretation of Qur'anic verses written by Abdul Malik Karim Amrullah (Hamka) during his prison sentence. Hamka is an Indonesian philosopher who is also actively involved in teaching Islam through his country's educational system. The Al-Azhar exegesis book is notable for its use of rhetoric to explain the meaning of Qur'anic verses for Muslims' comprehension of the Arabic text of the Qur'an. The purpose of this research is to examine the rhetorical strategy employed in Hamka's Tafseer Al-Azhar. By referencing the exegesis content of Fatihah verses in Tafseer Al-Azhar, this study focuses solely on the rhetorical method of Al-Mau'izah Al-Hasanah. This study employed the qualitative method by analyzing the content of books and journals related to Tafseer Al-Azhar. The rhetorical material in Tafseer Al-Azhar is distinctive in that Hamka used rhyme and aesthetics language to convey the narrative of its interpretation. It is interesting to mention that Islamic Animation Storytelling of Qur'anic verses could be derived from the rhetorical substance provided in the Tafseer Al-Azhar.
Conservation Situation and Social Network Analysis of Industrial Heritage in Tangshan City, China
Authors: Li Aimin ,   College of Creative Arts, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia, Abdul Wahid Wahiza ,   College of Creative Art, Universiti Teknologi MARA, Puncak Alam Campus, Selangor, Malaysia
Published: July 2024

Due to rapid urbanization development, industrial heritage is gradually being replaced by luxury residential buildings. Heritage is an asset of collective interests and made up of inherited tangible and intangible attributes. Since the late twentieth century, much attention has been paid to the analysis of industrial heritage, as it stands witness to the significant influence of industrial civilization on the economy, social development, and human production. The objectives of this research are to evaluate the economic, cultural, and historical values of industrial heritage in Tangshan, China and renew this heritage from the perspective of the cultural industry. Combination analysis of qualitative and quantitative methods is used to reflect the conservation situation of industrial heritage in this city and also evaluate the accessibility of these heritage to show their potential for renewal based on the data from surveys and statistical yearbooks. The results show that the present situation of the conservation of industrial heritage in Tangshan is developing rapidly, and the cultural industry becomes not only an attractive means for promoting the development of iron and steel, coal mining, and cement industry, but also inheriting industrial culture of these industries. Meanwhile, based on the quantitative analysis results, indicating that Kailuan Coal Mine and Tangshan Railway Site receive the highest concern from the government from the perspective of transportation for their conservation and renewal. This research can provide scientific basis for the value assessment and future renewal of industrial heritage for other heavy industry-based regions.
Allogeneic hematopoietic stem cell transplantation outcomes in pediatric patients with refractory acute myeloid leukemia
Authors: Ilyushina M. A. , Shelikhova L. N. , Shasheleva D. A. , Dunaykina M. A. , Blagov S. L. , Kurnikova E. E. , Pershin D. S. , Kalinina I. I. , Muzalevsky Ya. O. , Kazachenok A. S. , Brilliantova V. V. , Olshanskaya Yu. V. , Kazakova A. N. , Zerkalenkova E. A. , Baydildina D. D. , Balashov T. D. , Maschan A. A. , Maschan M. A.
Published: July 2024

Hematopoietic stem cell transplantation (HSCT) is known to be most effective in cancer patients in remission. In this paper, we analyzed a cohort of children with refractory acute myeloid leukemia (AML) in order to study the effectiveness of HSCT in such patients. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology and was conducted in accordance with the principles of the Declaration of Helsinki. All the patients and/or their legal representatives signed an informed consent form for participation in the study. Our retrospective analysis included 69 patients with refractory AML (induction failure (n = 31), refractory relapse (n = 38)) whose median age was 9.4 (1.1–22) years and who had undergone HSCT between February 2012 and January 2020, with the median follow-up of 5.47 (1.9–8.9) years. Fifty patients were transplanted from haploidentical donors, 10 – from matched related donors, 9 – from matched unrelated donors. All the patients received treosulfan-based conditioning and either melphalan or thiotepa. Fifty-five cases received TCRab+/CD19+-depleted HSCs (CliniMACS), 11 patients received native bone marrow and 2 – unrelated umbilical cord blood. For post-transplant relapse prevention, 21 patients were treated with hypomethylating agents in combination with bortezomib and 48 patients received modified donor lymphocyte infusions. Primary engraftment was achieved in 66 out of 69 patients (3 patients had died before engraftment). By Day +30, 86% of patients showed complete chimerism. The cumulative incidence of grade II–IV acute graft-versus-host disease was 42%, chronic graft-versushost disease was diagnosed in 17 pts. In the entire cohort, transplant-related mortality was 7.8% and cumulative incidence of relapse was 53%. NK cell recovery by Day +30 was significantly associated with decreased incidence of relapse: patients whose absolute NK cell counts were below the median had a cumulative incidence of relapse of 76% versus 43% in patients with NK cell counts above the median (p = 0.013). At a median follow-up of 5.5 years, the event-free survival was 37 ± 11%, and the overall survival was 42 ± 10%. Remission was achieved in 86% of the patients, while long-term overall survival reached about 40%. Our findings suggest that allogeneic HSCT provides a reasonable chance of cure in children with refractory AML and creates a solid basis for further improvement. Tumor burden in the bone marrow before conditioning and early post-transplant NK cell counts in the blood were found to be the most significant prognostic factors in HSCT.
A morphometric analysis of platelets using transmission electron microscopy
Authors: Kuznetsova A. A. , Kireev I. I. , Obydennyi S. I.
Published: July 2024

Platelets are the second most abundant human blood cells. They have an important function to form blood clots at sites of vascular injury to prevent bleeding. Abnormalities of platelet structure can lead to various dysfunctions and life-threatening situations. In some hereditary platelet disorders, morphological examination of platelets with transmission electron microscopy (TEM) may be required. TEM is technically complex, and its use is limited due to the need for expensive equipment and trained personnel. In our study, we assessed the morphometric parameters of platelets obtained from 20 healthy donors using TEM. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.
Experience in manufacturing a haploidentical biomedical cell product enriched with regulatory T-lymphocytes
Authors: Vedmedskaia V. A. , Pershin D. E. , Fadeeva M. S. , Sozonova T. A. , Malakhova E. A. , Kulakovskaya E. A. , Lodoeva O. B. , Musaeva E. Ya. , Muzalevskiy Ya. O. , Kazachenok A. S. , Osipova D. S. , Badrin E. A. , Belchikov V. E. , Melkova A. K. , Shelihova L. N. , Balashov D. N. , Maschan M. A.
Published: July 2024

Graft-versus-host disease (GVHD) remains the main life-threatening immunologic complication of hematopoietic stem cell transplantation. Despite modern pharmacological approaches for preventing and treating GVHD, there remains a need for new approaches to cure GVHD. Currently, more and more clinical experience is emerging globally in the field of using regulatory T-cell (Treg) therapies for the treatment of refractory GVHD. Manufacturing cell products for Treg therapies has a wide range of protocol variations. We have developed an approach of Treg manufacturing for cell therapy and present data from our experience in manufacturing a haploidentical Treg cell product by combining CD25+ immunomagnetic selection with closed system flowbased cell sorting methods. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The study describes the processes of producing 9 Treg cell products. According to the manufacturing protocol described here, it is possible to obtain a cell product that meets the quality control requirements necessary for approval for clinical use. Quality control includes the assessment of the cell composition, viability, and microbiological safety of the product, and is performed at all major stages of production. The final cell product is characterized by consistently high levels of FoxP3-expressing Treg (median: 98%), with a median cell viability of 99.1%, and has a high potential for functional efficacy. Thus, the protocol for producing Treg cell products by combining CD25+ immunomagnetic selection with flow cytometry-based cell sorting methods can be used for the clinical treatment of GVHD.