bluuebunny/crossref_metadata_2025 huggingface dataset:
Transferencia tendinosa del primer radial externo al cubital posterior: ¿mejora significativamente la corrección de la desviación radial en la muñeca reumática?
Authors: Abrego Mariano Oscar , Holc Fernando , Rellán Ignacio , Donndorff Agustín Guillermo , Gallucci Gerardo Luis , Boretto Jorge Guillermo , De Carli Pablo
Published: December 2023

Introducción: La artritis inflamatoria puede conducir al síndrome de caput ulnae con desviación radial de la muñeca y los metacarpianos. El tratamiento es la artroplastia de rescate de la articulación radiocubital distal y la reubicación del tendón del extensor cubital del carpo (ECC). Sin embargo, puede ser débil para corregir la desviación. Clayton describió la transferencia del tendón del extensor radial largo del carpo (ERLC) al ECC. El objetivo de este estudio fue comparar la corrección de la desviación radial de los metacarpianos en pacientes operados con transferencia del ERLC al ECC o sin ella.
Materiales y Métodos: Estudio de cohorte retrospectiva en pacientes con artritis reumatoide y síndrome de caput ulnae, sometidos a tenoplastia del ECC con ERLC o sin este procedimiento. Se formaron dos grupos: pacientes con transferencia (grupo A) y sin transferencia (grupo B). Se calculó la corrección del ángulo de Clayton comparando las medidas preoperatoria y del último control, y se compararon los resultados.
Resultados: El seguimiento promedio fue de 28 meses. El ángulo de Clayton preoperatorio promedio era de 44,54° (DE ± 7,52) en el grupo A y 60,24° (DE ± 12,28) en el grupo B (p = 0,001). El promedio de corrección fue de 6,57° (DE ± 4,11) y 0,95° (DE ± 9,17), respectivamente (p = 0,026).
Conclusiones: El nivel de corrección fue mayor en el grupo A. No obstante, si bien ambas técnicas lograron mejorar el ángulo, el grado de corrección podría estar supeditado a la magnitud del ángulo preoperatorio.
Notas sobre as atribuições privativas dos(as) assistentes sociais no contexto da pandemia de covid-19
Authors: Bezerra Angélica Luiza , Medeiros Milena Gomes
Published: December 2023

Este artigo versa sobre as atribuições privativas dos(as) assistentes sociais no contexto de calamidade pública deflagrada pela pandemia de covid-19, cuja principal característica, no âmbito social e econômico, foi o aprofundamento da desigualdade social. Desse modo, nosso objetivo é trazer para o debate os desafios postos à profissão mediante suas atribuições privativas em um contexto que também demarcou mudanças significativas na atuação devido às novas demandas que exigiram do profissional novas competências, evidenciando a necessidade de uma formação continuada. Do ponto de vista metodológico, nos baseamos em referências bibliográficas e nos principais documentos que fundamentam a profissão.
Psychological Development of Preschoolers in Project-Based Learning: An Overview of Empirical Research
Authors: Plotnikova Valeriya A. , Veraksa Alexander N. , Veraksa Nikolay E.
Published: December 2023

Introduction. The search for technologies to provide the harmonious development of preschoolers through the enrichment of children’s activities inherent in this age period is an urgent task for the modern education system. Recently, along with traditional forms of education, front-line work and free play, project-based learning has become widespread in kindergartens. To clarify the fundamental features of project-based learning and its developmental effects, a review of empirical studies on this topic was conducted. The purpose of the article is to present the results of the review and identify the main trends, limitations and prospects of studying the project-based learning impact on the psychological development of preschoolers. Materials and Methods. The literature review was conducted using the PRISMA. As a result of the search, 789 Russian-language publications and 687 English-language publications corresponding to the search query were found. As a result of screening and selection, 18 studies were included in further qualitative analysis. For the qualitative analysis a validated checklist of questions was used to assess the methodological level of quality of randomized and non-randomized studies (max. score 26). Results. 7 out of 18 studies satisfied less than half of the items on the checklist and scored less than 13 points, which indicates insufficient reliability of the results obtained in these works. As the result it was sufficiently reliably shown that the use of project approach in preschool age can positively affect the development of social and research skills, cognitive abilities, creative abilities and speech. Discussion and Conclusion. The review showed main trends in the field of studying the developmental effects of project-based learning, reflecting possible research directions in this area. The most promising perspectives for further research are connected with the comparison of the project approach with other forms and methods of education, which can contribute to determining the specifics of different educational methods and determining the conditions for their most effective use. The materials of the article would be useful for planning research in the field of child development, as well as for organizing project-based learning in educational institutions.
Current Research on Inclusive Education in Mexico
Authors: Gajardo Katherine , Cáceres-Iglesias Judith , Santamaría-Cárdaba Noelia , Meza-Cortés Ana Fabiola
Published: December 2023

Introduction. The study of access, participation and learning for people with disabilities in Mexico has been a recurring theme in the country’s educational research, however, its treatment over the last three decades has been superficial and contradictory. Based on a systematised literature review, guided through the PRISMA-S checklist and by means of a qualitative content analysis we describe and analyse the most developed themes and approaches in Mexican research published in indexed journals on the education of people with disabilities over the last nine years.
Materials and Methods. Based on the protocols, reviews were conducted in multiple databases and the results were limited to Ibero-American journals published between 2013 and 2021. Keywords in Spanish related to disability and inclusion were used for the search. Inclusion criteria specified Mexican authorship or analysis of the Mexican context, blind peer review and relevance to Social Sciences teaching. The analysis involved a coding process focusing on the epistemic positioning, main themes and transformative aims of the research, providing a descriptive overview of academic articles.
Results. The results highlight that the studies, for the most part, tend to be empirical research reports promoted by female re-searchers from Mexican public universities, a large part of the studies are situated in the paradigm of inclusive education and the objectives of the research tend to study the conditions of schools and universities. During the analysis process, 13 thematic sub-dimensions were identified, of which two stand out: 1) initial and in-service teacher training and 2) inclusive education policies. The study points out some contradictions between the theoretical approach selected by the authors and their own forms of research; the scarcity of socio-critical research and a worrying need for funds to develop transformative projects in Mexican schools.
Discussion and Conclusion. The study calls for expanded international research efforts to collectively improve educational conditions for people with disabilities.
Personalizing the Way of Teaching LSP
Authors: Makarova Tatiana S. , Matveeva Eugenia E. , Molchanova Maria A. , Morozova Elena A. , Burenina Natalia V.
Published: December 2023

Introduction. The problem of effective teaching language for special purposes (LSP) to the students of non-linguistic professions has been discussed for a long time and in full details by academicians both in Russia and foreign countries. As the result of multiple and thorough surveys general problems of the given situation have been revealed, the way out being defined as special training/retraining of LSP teachers. But in language education publications it is hardly possible to find the description of the program aiming at the training of the above mentioned teachers. The aim of the article is to present effective approaches to teaching LSP and offer the developed master program “Methods of teaching LSP” as a means to solve the problems mentioned above.
Materials and Methods. The research methods used are a combination of analytical review of studies by Russian and foreign researchers and interpretation of the results obtained by interviewing university teachers specializing in teaching foreign languages to students completing Bachelorʼs or Masterʼs degree programs. The survey was conducted to assess the level of readiness of professional educators to design the structure and content of programs for teaching LSP, and actually conduct classes within the specified language-teaching area, 81 teachers being responders.
Results. As a result of the undertaken review of theoretical works and analysis of the conducted survey a master program “Methods of teaching LSP” was designed for training graduates who will then teach English or Russian as a foreign language at industry-specific higher schools. The developed program focuses on instructing future LSP educators to work out a personalized educational route adjusted to the level of foreign language skills of a student and their prospective professional activities.
Discussion and Conclusion. The master program developed by the authors as well as the content of the subjects suggested as its integral part are expected to become a productive way of training LSP educators who are supposed to acquire a number of special skills and competences described in the article. Distant learning and e-learning technologies are also engaged in the program to facilitate learners’ more efficient independent activities. The master program is seen as one of the means of modernizing LSP teachers’ professional training which meets the long-term needs of the Russian education system.
Numerical and digital image correlation study of the flexural behavior of prestressed ultra-high-performance concrete beams made from locally available materials
Authors: Sun Wei , Weldon Brad D. , McGinnis Michael J. , Jiang Ruinian
Published: December 2023

This paper presents finite element simulations of the flexural behavior of three prestressed ultra-high-performance concrete (UHPC) beams based on the concrete damaged plasticity model (CDPM) available within Abaqus. A novel numerical model that applies the prestressing force through surface traction is proposed. The flexural deformation of the prestressed UHPC beams is simulated from the application of the prestressing force through failure under flexural loading. Material properties were measured and informed values for CDPM input parameters. The model was compared with four-point loading tests previously conducted to study the flexural behavior of large-scale prestressed UHPC beams. Digital image correlation (DIC), supplemented with traditional sensors, was used during the test to monitor behavior. The primary results based on the numerical modeling are as follows: • The model is validated to accurately simulate the flexural behavior of prestressed UHPC beams, both in global deflection and local strain. • The prestressing process, including camber deformations, is effectively simulated. • The new approach to apply prestressing force in the model can be applied in scenarios requiring large prestressing forces. • The numerical results are also validated through comparison with DIC results. The new numerical modeling approach will be effective for guiding experimental studies and design of prestressed UHPC beam elements.
THE ROLE OF BIODEGRADABLE NONWOVEN FABRICS IN EFFICIENT SODDING OF EARTH STRUCTURES
Authors:   Department of Agroecology and Plant Production, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120, Kraków, Poland, Kacorzyk Piotr , Starzec Katarzyna ,   Department of Plant Biology and Biotechnology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120, Kraków, Poland, Kaszycki Paweł ,   Department of Plant Biology and Biotechnology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120, Kraków, Poland, Supel Paulina ,   Department of Plant Biology and Biotechnology, University of Agriculture in Krakow, Al. Mickiewicza 21, 31-120, Kraków, Poland
Published: December 2023

Aim of the study: Newly formed earth structures such as ski slopes are areas causing difficulties in attempts for efficient sodding since colonization with plants, their initial development and adaptation are hindered due to unfavorable climatic and soil factors. The main aim of the study was to demonstrate the feasibility of using nonwoven fabrics made from sheep's wool and waste poultry feathers on steep-gradient mountain slopes. Material and methods: Biodegradable geotextiles can be used not only to protect seeds and soil from washout, but also to promote turf development and improve soil microbial quality. During the experiment, plant growth was monitored together with microbial frequency changes. Results and conclusions: The results showed that the application of nonwoven fabrics after sowing a mix of grasses and clover had many advantages including the acceleration of seedling germination, improvement of plant initial development and increase of the number of plants per m2. The final biostimulation effect was found to be strongly dependent on geotextile biodegradability, grammage and the fleece structure. The best yield was obtained with the nonwoven grammage within the range of 150 - 180 g·m-2. The promotion of plant growth and, in particular, the development of the root system had a significant positive impact on the population of soil microbiota.
$\mu-e$ conversion in a model of electroweak scale right-handed neutrino mass
Authors: Dinh Dinh Nguyen , Thi Man Duong , Thi Nhuan Nguyen
Published: December 2023

We perform a detailed analysis of the \(\mu-e\) conversion within an extended version of the standard model (SM) with mirror symmetry and low energy of the electroweak scale of the type I seesaw neutrino mass generation. After a brief introduction to the model, we derive the \(\mu-e\) conversing ratio at one-loop approximation, in which the running inside are W gauge boson or singly charged scalars accompanying with neutrinos, and neutral scalars with new leptons. We focus, mainly, on predictions of observable possibilities and constraints set on relevant couplings from the \(\mu-e\) conversion in nuclei.
Język mistyki przyrody w dziełach św. Franciszka
Authors: Dymowski Eligiusz
Published: December 2023

Saint Francis of Assissi is not only one of the most well-known and popular saints of the universal Church, but also medieval poet and troubadour, brother of the “small”, the simple and the poor. In spite of being a well-educated medieval scholar, he became a bard of praise for all creation. His life was full of faith and prayer, and he himself in this life wanted to faithfully follow Christ, imitating Him. He wanted to revive the evangelical ideal of Christ in personal worship of God on a daily basis through full admiration and his admiration of the world God created. In this way, he was not only the creator of mystical works, but also articulator of the universal values that a man dreams about and for which a human being entangled in sin always strives. An expression of this coherence of faith and admiration for beauty is his famous “Song of the Sun, which has permanently entered the canon of world literature. The great admiration and respect for God, another man and nature fully reflect Francis’ admiration expressed in an inspired word through which the Poor Man of Assisi teaches others this subtle but extremely important verbal form of communication, outstanding and characterizing, making every thinking person different from all other creatures.
Moralna odpowiedzialność za słowo
Authors: Królczyk Małgorzata
Published: December 2023

Man created – in God’s image – is valuable and therefore deserves dignity. However, we live in a world full of hatred and contempt for our neighbour. In our families there is often no dialogue and no respect for one another. The phone often becomes a digital pacifier, replacing the presence of a parent. Therefore, as the basis for education, action should be taken to deepen the sense of dignity, both of one’s own but also of another person’s. Therefore the education for proper communication must begin at a child’s early age. We also need to teach young people to be morally responsible for every word they say.
Bilingual Signs: How Language Influences Shoppers
Authors: Mantel Susan , Kellaris James
Published: December 2023

A growing use of bilingual signage among retailers in the United States begs the question, How do shoppers react to bilingual signs? How is such signage processed by consumers, what does it signal, and to what effect? Drawing from a national panel of American consumers, we exposed participants to examples of English, bilingual, or Spanish signage in a program of experiments that measured behavioral intentions, attitudes toward the stores and signs, and various expectations, perceptions, and impressions. Results show a direct effect of the language of the sign on shoppers’ behavioral intentions to engage with and buy from a store. Evidence shows that evaluations of signs shape evaluations of the stores they represent. Additionally, the language used on signs shapes shoppers’ expectations of service quality, with bilingual signs engendering favorable impressions of authenticity, inclusiveness, and interestingness. Signs using only a foreign language, by contrast, tend to lower expectations of service, communication, and inclusiveness.
Visual Mixed Messaging: The Role of Signage in Public and Private Governance of New York City Interior Privately Owned Public Spaces
Authors: Donahue Alex , Simon Madlen , Brown Madeline
Published: December 2023

New York City’s Interior Privately Owned Public Spaces (IPOPS) provides developers with bonus floor area in exchange for the urban amenity of publicly accessible space. Many issues can arise in jurisdictional overlap when city authorities and private owners govern space. Upon entering the front door of an IPOPS, one may encounter signage placed by private owners stating explicit rules discouraging specific uses, while city-mandated signage must state that the space is “open to the public.” Given recent efforts to replace publicly regulated POPS signage, this study provides a timely assessment. The research question is: Do private owners’ signs communicate in a manner that narrows the definition of “public”? Our research method includes transcribing all externally visible signage, including city-regulated signage and owner signage and performing a text analysis with R to discover the prevalence of language inviting use and regulating behavior. We analyze the data to discover how in contrast to city-mandated signage, owner signage tends to narrow the definition of “public.” We explore the implications for the governance and administration of public space.
On-Premise Signage and Placemaking: Aiding Lively Streetscapes to Maintain Signage Visibility
Authors: Dalton Robert , Abbasi Sahand , Han Seojoo
Published: December 2023

Placemaking is an initiative with roots in the 1960s and 70s to enhance public life in the urban setting. This complex notion requires multiple disciplines, flexibility, and a human-centric approach toward development. While developing new streets and enhancing the existing, built environment, professionals, community residents, and business owners must consider multiple elements to bring people to the street: furniture, vegetation, walkability, art, and culture. With this sidewalk interaction comes the opportunity for economic development. When the people are drawn in, signage can inform the pedestrian. This study builds a collection of 200 photos, representing four levels of placemaking intensities. Each photo is coded into 600 cells to count the quantity of placemaking elements. Visual attentive software (VAS) is then used to measure the sign effectiveness to visually stand out. Placemaking initially impacts preattentive visibility, while the building façade, road surface, tree canopy, landscaping, and the sky each play a role. Planners, designers, and business owners can use these findings to better inform the impact and interaction of streetscape and business.
Competencias digitales en docentes de educación superior
Authors: Álzate Gallego Yorladis , Parra Bernal Lina Rosa
Published: December 2023

El COVID–19 generó en las instituciones de educación superior el reto de desarrollar los procesos formativos mediados por tecnologías, además de develar en los profesores limitantes frente al uso de recursos digitales pedagógicos existentes en la red. Esta situación relevó la cualificación docente como un mecanismo clave en la adquisición de competencias digitales; que en palabras de Álzate et al. (2022) “está orientada a la apropiación de las tecnologías para el diseño de ambientes educativos innovadores, con los cuales se favorece la enseñanza con sentido crítico, reflexivo y creativo, respondiendo a una formación que potencie el aprendizaje”, (p. 47)

Por tanto, es importante que el profesor de educación superior reflexione acerca de la manera en que enseña y como aprenden sus estudiantes. Con el interés de contribuir en la discusión, se propone esta investigación, que identificó el nivel de competencia digital que poseen los docentes, reconociendo su tipología asociada con el “diseño, implementación de espacios educativos significativos mediados por TIC”, (Valencia, et al. 2016. p. 16).
La inteligencia artificial en la educación
Authors: Norman-Acevedo Eduardo
Published: December 2023

La inteligencia artificial es una tecnología emergente que ha revolucionado la forma en que interactuamos con el mundo. En el ámbito de la educación, la IA puede ser una herramienta valiosa para los tutores virtuales universitarios y profesores universitarios. Sin embargo, como cualquier tecnología, la IA tiene sus pros y contras. La UNESCO ha señalado que la inteligencia artificial tiene la capacidad de hacer frente a algunos de los mayores desafíos que afronta el ámbito de la educación, de desarrollar prácticas de enseñanza y aprendizaje innovadoras y, finalmente, de acelerar el progreso en la consecución del Objetivo de Desarrollo Sostenible (ODS) 4. No obstante, estos avances tecnológicos rápidos implican inevitablemente numerosos riesgos y retos. Es importante tener en cuenta que la IA no es una solución mágica que pretendería reemplazar a seres humanos de sus roles tradicionales. La salida de la IA debe ser complementada y supervisada.
Aulas hospitalarias
Authors: Patricia-Cleves Gina , Arango-Celis Jenni , Celis-Murcia Luz Mery , Valencia-Rivera William , Giraldo Cerón Yonth Jairo
Published: December 2023

Esta investigación nace del interés de indagar y conocer entornos educativos fuera de la enseñanza regular, en este caso, la pedagogía hospitalaria y la educación inclusiva, las cuales atienden académicamente a niños, niñas y jóvenes en estado de enfermedad crónica, evitando que no se genere retraso en su proceso académico ni en su vida. Una pedagogía en donde se involucren y trabajen todos los aspectos integrales del ser humano teniendo en cuenta la recreación, lo intelectual, la orientación y el apoyo psicológico que le puede ayudar a afrontar el cambio de vida, y los cuidados que debe tener por su nueva condición. Teniendo en cuenta la formulación del problema, donde se aplica un enfoque cualitativo bajo un esquema metodológico de tipo descriptivo, con una muestra de 30 niños con enfermedades crónicas, aplicando entrevista semi estructurada y observación no participativa a los padres de familia y personal médico que se involucra en el día a día con pacientes de patologías crónicas. En los resultados se evidencio, que en los hospitales y clínicas no poseen personal, ni infraestructura, espacios y elementos para brindar servicios educativos a los niños hospitalizados. Es importante concluir que debido al número de niños hospitalizados y a los prolongados tiempos que deben permanecer atendiendo su tratamiento, es necesario que las instituciones de salud adopten las aulas hospitalarias, no sólo como medida para garantizar el derecho a la educación de sus pacientes, sino como medio efectivo para contribuir a la recuperación de su salud física y emocional. Lo que se busca es que la educación con pedagogía curativa sea trabajada con un equipo multidisciplinar, que involucre a padres de familia, médicos, psicólogos, cuidadores, en donde cada niño y joven hospitalizado sienta apoyo y vea que su futuro sí puede mejorar.
Unknown Prayers from the Old Russian Parchment Psalter of the Studite Era
Authors: Shchepetkin Anton
Published: December 2023

This article examines the specifics of the set of prayers in the Old Russian psalters of the Studite era (before the early fifteenth century). The psalters of this period were distinguished by a wide variety of prayers after cathismata (in contrast to the modern psalters with a fixed set of prayers). Pre-revolutionary researchers, such as archimandrite Amphilochius (Sergievsky-Kazantsev) and V. Pogorelov and modern scholars G. R. Parpulov and priest Ilia Shugaev, examined the issue. However, most of these researchers considered not all but only part of the Old Russian psalters. Since many Old Russian prayers remain unexplored and unpublished, this issue is still relevant for scholarship. This article is devoted to the parchment manuscript of the Typographic Collection No. 28 (mid-fourteenth century) kept in the Russian State Archive of Ancient Acts. The set of prayers of this psalter is considered against the background of a wide range of Old Russian psalters, horologia, and liturgical collections. The manuscript contains 17 prayers. Only three prayers are now in liturgical use; three prayers are typical of Old Russian psalters and horologia; four prayers are less common and can only be found in some cases. The rest are either rare or (partially or completely) unique. Five of these 17 prayers make part of the early printed editions of the Psalter (1632 and 1636). The Greek original of some prayers is known (in particular, two prayers originate from Pandektos by monk Antiochus), while some of the rest may be the creation of a Slavic author. The published text of four prayers from this manuscript (after cathismata 9, 11, 18, and 20) has never been examined previously. In terms of their message, the prayers are diverse as their tone varies from repentance to praise, with a pronounced didactic note. The author skillfully and professionally quotes the Bible and the Triodion (prayer after cathisma 11) and conveys the “sobbing” intonations of lamentation (prayer after cathisma 18).
Becoming Pastors: The Russian Orthodox Parish Clergy and Civil Society in the Last Decades of the Russian Empire
Authors: White James
Published: December 2023

The American scholar Daniel Scarborough has written a monograph dedicated to the history of the Russian Orthodox clergy in the late imperial regime. This work both encapsulates recent developments in the historiography of the imperial Russian Orthodox Church and contributes fresh archival research, principally using documents held in repositories in Moscow and Tver. His main focus is the mutual aid networks in which the clergy participated. Created over the course of the nineteenth century, these mutual aid networks were initially aimed at distributing resources among poor members of the clerical estate: the development of these networks was facilitated by the freedom of association granted to the clergy by the imperial state. In the late nineteenth and early twentieth centuries, Scarborough argues, these networks began to lose their estate focus, both supporting and including members of the laity: this was partially a response to the fact that the material position of the clergy was heavily dependent on the material condition of the laity and partially due to the fact that the clergy slowly began to lose their estate focus and transform into a profession focused on the spiritual and material wellbeing of the Orthodox flock. Scarborough emphasises several key moments (such as the famine of 1891–1892) and institutions (the seminary, for example) to demonstrate the extent to which clerical support networks included members of the laity and the forces that either facilitated or blocked this development. He concludes that while the clerical mutual aid networks did succeed, to some extent, in incorporating members of the laity, they were hampered by the imperial state’s attempts to strictly control the clergy and use them as cheap civil servants, police officials, and propagandists: equally, while sometimes supporting the expansion of clerical aid networks, the episcopate and the Synod was often concerned to ensure that the Church’s thinly-spread resources were mostly used to support the members and institutions of the clerical estate. All of this damaged the prestige of the clergy in the eyes of their parishioners and made them less willing to transfer scarce resources to clerical networks. Only with the all-Russia local church council of 1917–1918 did the Russian Orthodox Church fully incorporate the laity, a step which allowed the institution to survive Bolshevik rule.
Association of left ventricular structural remodeling types with fibronectin deficiency in patients with multivessel coronary artery disease
Authors: Mingalimova A. R. , Gumanova N. G. , Bikbova N. M. , Dzhioeva O. N. , Pokrovskaya M. S. , Efimova I. A. , Serebryanskaya Z. Z. , Bogdanova N. L. , Borisova A. L. , Drapkina O. M.
Published: December 2023

Aim. To evaluate the serum fibronectin level in patients with multivessel coronary artery disease, and to identify the relationship of fibronectin level with atrial fibrillation (AF) developed in the hospital after coronary artery bypass grafting (CABG) and types of left ventricular (LV) structural remodeling.

Material and methods. This prospective observational study of 80 patients after elective CABG at the Cardiac Surgery Department № 1 of the N.V. Sklifosovsky Research Institute for Emergency Medicine from October 2020 to May 2022. The groups were divided depending on the development of AF after CABG surgery (19 patients with AF developed in the hospital after CABG (up to 10 days), 61 patients — control group). All patients underwent a general clinical examination and transthoracic echocardiography, with estimation of left ventricular remodeling type. Serum fibronectin level was determined by enzyme immunoassay using the Fibronectin agent (Technozym, Austria).

Results. The median fibronectin values in the group with AF was 110,10 [86,86; 134,00] mcg/ml versus 120,90 [92,01; 161,50] µg/ml of the comparison group (p=0,19). The following LV patterns were observed: normal LV geometry (NLVG) — in 1 patient (5,26%), concentric LV remodeling (CLVR) — in 3 patients (15,79%), concentric LV hypertrophy (CLVH) — in 10 patients (52,63%), eccentric LV hypertrophy (ELVH) — in 5 patients (26,32%). In the group without AF, 25 patients (40,98%) were diagnosed with NLVG, 26 patients (42,62%) — CLVR, 6,56% (n=4) — CLVR, while ELVH was diagnosed in 6 patients (9,84%). Differences in geometry types between groups were significant (p<0,0001). Multivariate analysis adjusted for gender, age, cardiopulmonary bypass time, the predictive value remained for CLVH — odds ratio 15,83 (95% confidence interval, 4,082-1,442,00; p=0,0001) and ELVH — odds ratio 5,17 (95% confidence interval, 1,365-19,573; p=0,015). A further study showed that fibronectin <116,496 µg/ml with a sensitivity of 78% and specificity of 53% is associated with CLVH (p=0,006) in patients of both groups.

Conclusion. Fibronectin <116,496 µg/ml is associated with CLVH in patients with multivessel coronary artery disease (sensitivity 78%, specificity 53%; p=0,006).
BDNF/TrkB signaling in stable coronary artery disease
Authors: Atamas O. V. , Antonyuk M. V. , Novgorodtseva T. P. , Gvozdenko T. A. , Kytikova O. Yu.
Published: December 2023

Aim. To study the serum content of brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) in patients with coronary artery disease (CAD) and evaluate the relationship of BDNF/TrkB signaling with the severity of coronary atherosclerosis, systemic inflammation (IL-2, IL-4, IL-6, IL-10, TNF-α) and angiogenesis (VEGF).

Material and methods. The study included 99 patients with stable CAD who underwent coronary angiography and 30 healthy volunteers. Coronary atherosclerosis was assessed using the Gensini score (GS). In blood serum, the concentrations of BDNF, TrkB, VEGF, IL-2, IL-4, IL-6, IL-10, TNF-α were determined using the enzyme immunoassay. Cluster, correlation, and regression analyzes were used.

Results. In patients with CAD, a wide range of variations in BDNF concentrations was observed. To determine homogeneous groups using the k-means clustering, three clusters with different BDNF/TrkB axis vectors were identified. Patients differed in the severity of coronary atherosclerosis, the manifestation of the inflammatory reaction, and the intensity of angiogenesis. In patients with initial and moderate atherosclerotic changes in the coronary arteries, a normal concentration of BDNF and an increased level of TrkB (22,35/1,18 ng/ml) were noted. In patients with severe coronary atherosclerosis, two different BDNF/TrkB variants have been identified. Decreased BDNF and increased TrkB (6,0/1,52 ng/ml) were associated with low VEGF and increased IL-6. Elevated BDNF and normal TrkB values (26,95/0,96 ng/ml) were characteristic of patients with high VEGF expression, indicating angiogenesis activation and/or vulnerable plaques. A direct relationship between BDNF and VEGF (r=0,536, p<0,001) and an inverse relationship with TrkB (r=-0,301, p=0,019), IL-6 (r=-0,306, p=0,002) was revealed. TrkB levels were correlated with TNF-α (r=0,403, p=0,001). Regression analysis showed that BDNF expression is influenced by TrkB (β=-0,237, p=0,009), VEGF (β=0,490, p<0,001), IL-6 (β=-0,339, p<0,001).

Conclusion. In patients with stable CAD, different levels of BDNF/TrkB expression were found, which were associated with coronary atherosclerosis severity. BDNF/TrkB signaling is involved in the regulation of inflammation and angiogenesis in stable CAD.
Observational study of inclisiran effectiveness in Moscow healthcare
Authors: Sapina A. I. , Varlamova Yu. Yu. , Papyrina M. G. , Bezymyannyy A. S. , Vasilyeva E. Yu.
Published: December 2023

Aim. To evaluate the effectiveness of PCSK9 inhibitors (alirocumab, inclisiran and evolocumab) in patients with atherosclerotic cardiovascular disease (ASCVD) and failure to achieve the target low-density lipoprotein cholesterol (LDL-C) level for the period from November 21, 2022 to December 31, 2023.

Material and methods. For the observational study, 50 patients were included in the inclisiran therapy group and 30 patients in the control group (patients with ASCVD receiving PCSK9 inhibitors (alirocumab, n=1; evolocumab, n=29)). All study participants had their anamnestic data analyzed, and initially underwent electrocardiography, echocardiography, extracranial and lower limb Doppler ultrasound, and laboratory tests (complete blood count, biochemical blood tests, lipid profile). Three medical organizations of the Moscow State Healthcare System participate in the study.

Results. Interim data are presented to evaluate the effectiveness of PCSK9 targeted therapy in patients with ASCVD, obtained 3 months from the study start. The comparison groups were comparable in main clinical characteristics. When analyzing the lipid-lowering effect of inclisiran in the examined patients with ASCVD, LDL-C level significantly decreased from 2,53±0,10 mmol/l to 110±0,08 mmol/l (by 56,5%), p<0,0001, while the target LDL-C level <1,4 mmol/l was achieved by 77,5% of the subjects. Analysis of the lipid-lowering effect of alirocumab/evolocumab showed a significant LDL-C decrease from 2,48±0,16 mmol/l to 1,07±0,11 mmol/l (by 56,8%), p<0,0001.

Conclusion. The use of PCSK9 targeted therapy (alirocumab or inclisiran or evolocumab) in patients with ASCVD in Moscow make it possible to achieve target LDL-C levels, which are indicated in clinical guidelines, by 3 months.
Role of sutureless aortic valve replacement in the era of transcatheter valves
Authors: Tsaroev B. S. , Bogachev-Prokofiev A. V. , Sharifulin R. M. , Afanasyev A. V. , Chernyavsky A. M.
Published: December 2023

This review article considers the role of sutureless aortic valve replacement in the era of transcatheter replacement. Modern data regarding the outcomes of treatment with these two methods and its comparison are considered. Their main disadvantages and the cohorts of patients suitable for each technique are determined.
Rationale for implementation study to introduce clinical guidelines on lipid metabolism disorders into routine practice
Authors: Usova E. I. , Alieva A. S. , Zvartau N. E. , Shlyakhto E. V.
Published: December 2023

Published studies demonstrate insufficient implementation of clinical guidelines into actual clinical practice. Successful implementation of diagnostic and treatment guidelines for patients with lipid metabolism disorders directly depends on the identification of barriers and timely application of strategies to overcome them. A three-level remote structural questionary of healthcare quality for patients with dyslipidemia involved practitioner, heads of outpatient medical organizations and chief outpatient specialists to identify key barriers to implementation and compliance with clinical guidelines in real world setting. The obtained data in combination with implementation science approaches will facilitate development of strategies aimed to improvement of compliance with the guidelines for the management of patients with lipid metabolism disorders in practice.
Restoring High Vaccine Coverage in Brazil: Successes and Challenges
Authors: Fernandes Eder Gatti , Werneck Guilherme Loureiro , Haddad Ana Estela , Maciel Ethel Leonor Noia , Lima Nísia Verônica Trindade
Published: December 2023

Facing the decline in vaccine coverage observed since 2016, the new Brazilian government committed to reversing this scenario. To achieve this, the Federal Government launched the National Vaccination Movement and the 'Health with Science' platform to combat vaccine misinformation, promoted Microplanning, providing tools for decision-making at the territorial level, allocated 30 million dollars to states and municipalities to implement innovative vaccination strategies, standardized the rules of the information systems for the registration of vaccine doses, and directed data to the National Health Data Network (RNDS). Reversing the declining trend of vaccination coverage in Brazil is challenging, but within just one year, it is possible to observe significant results from governmental actions. Out of the eight recommended vaccines by the age of one, seven showed an increase in vaccination coverage in 2023 compared to 2022: Most states showed improvements in vaccination coverage. Many challenges persist in advancing the vaccination agenda. However, there are reasons to celebrate the reversal of the declining trend in coverage of several vaccines in this first year of government and the increase in the number of municipalities that have fully achieved the vaccination coverage target. The National Vaccination Movement, with public opinion awareness, the resumption of regionalized communication campaigns, localized micro-planning actions including extramural vaccination strategies, and the integration of information systems, has been decisive in strengthening work in the territories and thus restoring a culture of immunization, a source of pride in the country and internationally recognized, throughout the 50 years of the National Immunization Program
Assessment of Economic Growth Prospects in Russian Regions Considering Import Sanctions
Authors:   Kazan (Volga Region) Federal University, Safiullin M. R. , Burganov R. T. ,   Volga Region State University of Physical Culture, Elshin L. A. ,   Kazan (Volga Region) Federal University,   Center of Advanced Economic Research in the Academy of Sciences of the Republic of Tatarstan, Mingulov A. M. ,   Kazan (Volga Region) Federal University
Published: December 2023

Sanctions restrictions and external pressure on the Russian economy resulted in significant transformations of cooperative foreign relations. Such developments require adaptive mechanisms to ensure sustainable economic growth at the macro- and meso-levels. In this regard, various studies aim to develop methodologies for building macroeconomic models adapted to institutional and market changes. The present article tries to solve this problem by proposing and testing approaches to the assessment of regional economic growth prospects by simulation modelling of localisation of transnational chains of foreign final and intermediate goods. It is assumed that there are critical imports to the region, which form the core of sustainable development risks considering changes in cross-border supplies. The methods of systematisation and grouping of regional economic risks due to import restrictions are utilised. Additionally, the study applies the correlation and regression and structural analysis to determine the impact of disturbances in economic relations on sustainable development of individual economic sectors of regions, formation of gross regional product (GRP) and growth prospects of the national economy. The case of the Republic of Tatarstan was examined. According to the negative scenario, which assumes the total restriction of critical import supplies to Tatarstan and inefficient use of import substitution mechanisms, a slowdown in the regional economy (-6.9 % of GRP) can be expected. The obtained estimates on the scale of Tatarstan determine the slowdown in Russia’s gross domestic product growth rates by 0.23 %. Projecting of the results to all Russian regions predicts a slowdown of 1.28 % of GDP for the whole country, which is within acceptable risks. The results can be used to develop adaptive mechanisms for state management of regional economy in the context of systemic transformations.
Study of Almost Periodic Solutions of Differential Equations
Authors:   St. Petersburg State University, Ivanov Gennadiy G. , Alferov Gennady V. ,   St. Petersburg State University, Korolev Vladimir S. ,   St. Petersburg State University
Published: December 2023

Conditions and found that allow to determine both the upper and lower bounds for almost peri-odic solutions of ordinary differential equations of the first order. Reviewed questions of the existence and stability of these solutions.
Studies of Elastomeric Nanocomposites Mechanical Behavior Under Biaxial Loading
Authors:   Institute of Continuous Media Mechanics UB RAS, Garishin Oleg K. , Shadrin Vladimir V. ,   Institute of Continuous Media Mechanics UB RAS,   Perm State University
Published: December 2023

Biaxial cyclic tests of elastomeric composites filled with granular nanoparticles (carbon black and detonation nanodiamonds), nanoplates (few-layer nanographene) and nanofibers (multi-walled carbon nanotubes) have been carried out. The experiments were carried out on Zwick/Roell's unique four-vector test stand using special fan-type cruciform specimens. Studies have shown that carbon nanotubes have the greatest influence on the change in the mechanical properties of a material during cyclic deformation in mutually perpendicular directions. It is they, due to their length and flexibility, that most effectively partic-ipate in the restructuring of the microstructure, thereby forming the macroscopic behavior of the material.
Experimental Study of Stress Concentration Near the Tips of V-shaped Cracks of Different Depths Filled With Various Materials
Authors:   Institute of Continuous Media Mechanics UB RAS, Fedorov Andrey Yu. , Galkina Elizaveta B. ,   Institute of Continuous Media Mechanics UB RAS, Slobodinyuk Aleksey I. ,   Institute of Technical Chemistry UB RAS
Published: December 2023

One of the ways to eliminate the stress concentration in the vicinity of tips of surface cracks (V-shaped notches) is to fill the crack cavity with material. The effectiveness of this variant depends on the crack opening angle, the properties of the original and filler materials, and the strength of adhesion between the filler and basic materials. The solutions to the problem of a crack with a filling material obtained in the framework of the theory of elasticity revealed a singular behavior of stresses in the vicinity of crack tips. The analysis of the solutions obtained demonstrate that at a certain combination of V-notch angles and material properties there are no singular solutions, which is the best option for eliminating stress concen-tration. In addition, it is shown that in case of singular solutions, the level of stress concentration depends on the nature of the stress singularity. It should be noted however that these results are of a qualitative nature. In this paper, based on theoretical results, we present the results of experimental study, which give a quantitative estimate of the level of stress concentration in the samples with a V-shaped notch filled with material at different values of the notch depth and notch angles and various mechanical characteristics of filling materials.
SYNTHESIS OF DISPERSED NICKEL BY THERMAL DECOMPOSITION OF FORMATE, ACETATE AND OXALATE OF NICKEL (II)
Authors:   Perm State University, Kamenshchikov O.Y. , Ketov A.A. ,   Perm State University, Korzanov V.S. ,   Perm State University, Krasnovskikh M.P. ,   Perm State University
Published: December 2023

The thermal decomposition of nickel (II) formate, acetate and oxalate by the synchronous thermal analysis method has been investigated. The metallic nickel as a final product in all cases in an inert atmosphere was established. Carbon oxide (IV) and water were found as a products of the gaseous decomposition by the methods of thermogravimetric analysis combined with mass spectroscopy. The conditions for obtaining powdered metallic nickel were found. The dispersion of the obtained nickel was measured by the scanning electron microscopy. It is shown that the resulting metallic nickel has a different dispersion depending on the initial salt.
PHASE EQUILIBRIUM INVESTIGATIONOF THE SYSTEM KH2PO4-KNO3-KCl-H2O AT 25 °С
Authors:   Perm State University, Kistanova N.S. , Chistina J.A. ,   Perm State University
Published: December 2023

The investigation of thephase equilibrium for the four-components water-salt system KH2PO4 – KNO3 – KCl –H2Oat 25 °Cis described. The compositions of invariant point and saturated it solid phase aredetermined, using the isothemal method of section. The experimental results show that only monopotassium phospate, potassium nitrate and potassium chloride are present in solid phase in the system.
METAL IONS EXTRACTION BY PHOTOMETRIC REAGENTS IN WATER – CATAMINE AB – AMMONIUM NITRATE SYSTEM
Authors:   Institute of Technical Chemistry UrB RAS, Chukhlantseva E.Yu. , Denisova S.A. ,   Perm State University, Lesnov A.E. ,   Institute of Technical Chemistry UrB RAS,   Perm State Agro-Technological University
Published: December 2023

The distribution of some metal ions in the water – catamin AB – NH4NO3 segregated system in the presence of dyes – alizarincomplexon, sulfarasazene, bromopyrogallic red, pyrogallic red, pyridylazonaphthol, capable of forming colored complexes with metals have been considered. The possibility of extraction-photometric determination of lead with pyrogallic red and copper with pyridylazonaphthol have been shown.