bluuebunny/crossref_metadata_2025 huggingface dataset:
Pregnancy Arrhythmias: Management in the Emergency Department and Critical Care
Authors: Conti Elena , Cascio Nunzio Dario , Paluan Patrizia , Racca Giulia , Longhitano Yaroslava , Savioli Gabriele , Tesauro Manfredi , Leo Roberto , Racca Fabrizio , Zanza Christian
Published: February 2024

Pregnancy is closely associated with an elevated risk of arrhythmias, constituting the predominant cardiovascular complication during this period. Pregnancy may induce the exacerbation of previously controlled arrhythmias and, in some instances, arrhythmias may present for the first time in pregnancy. The most important proarrhythmic mechanisms during pregnancy are the atrial and ventricular stretching, coupled with increased sympathetic activity. Notably, arrhythmias, particularly those originating in the ventricles, heighten the likelihood of syncope, increasing the potential for sudden cardiac death. The effective management of arrhythmias during the peripartum period requires a comprehensive, multidisciplinary approach from the prepartum to the postpartum period. The administration of antiarrhythmic drugs during pregnancy necessitates meticulous attention to potential alterations in pharmacokinetics attributable to maternal physiological changes, as well as the potential for fetal adverse effects. Electric cardioversion is a safe and effective intervention during pregnancy and should be performed immediately in patients with hemodynamic instability. This review discusses the pathophysiology of arrythmias in pregnancy and their management.
Early-Onset Colorectal Cancer: Are Neuroendocrine Tumors or Adenocarcinomas the Culprit? Analysis of the Largest U.S. Cancer Incidence Database, 2001–2020
Authors: Abboud Yazan , Fraser Madison , Qureshi Imran , Hajifathalian Kaveh
Published: February 2024

(1) Background: While prior data showed an increasing incidence of colorectal cancer (CRC) in young adults, the contribution of adenocarcinoma (ADC) and neuroendocrine tumors (NETs) to this trend is not well studied. Therefore, we conducted a comparative analysis of the incidence rates and time trends of colorectal ADC and NETs in young adults (aged 24–54) using the United States Cancer Statistics (USCS) database. (2) Methods: Age-adjusted CRC incidence rates between 2001 and 2020 were calculated and categorized by sex, histopathology, and stage at diagnosis. Annual percentage change (APC) and average APC (AAPC) were computed via joinpoint regression utilizing weighted Bayesian information criteria to generate the simplest trend. Pairwise comparative analysis of ADC and NETs was conducted using tests of identicalness and parallelism. (3) Results: In this study, 514,875 patients were diagnosed with early-onset-CRC between 2001 and 2020 (54.8% men). While CRC incidence was significantly increased, including both ADC (448,670 patients) and NETs (36,205 patients), a significantly greater increase was seen for NETs (AAPC = 2.65) compared to ADC (AAPC = 0.91), with AAPC difference = 1.73 (p = 0.01) and non-identical non-parallel trends (p-values < 0.001). This was most notable in males (AAPC difference = 1.81, p = 0.03) and for early-stage tumors (AAPC difference = 3.56, p < 0.001). (4) Conclusions: Our study, covering ~98% of the U.S. population provides the first comparative analysis of early-onset CRC histopathological subtypes, showing that the rate of increase of NETs in young adults is much greater than that of ADC. Given that patients with NETs with malignant behavior can experience significant mortality, our findings are importance, highlighting the rapidly increasing NET incidence in young adults and encouraging early screening that can improve outcomes.
Statistical Associations between Vestibular Pathologies and Hypothyroidism: A Retrospective Study
Authors: Bougerolle Virginie , El Khiati Rhizlane , El Ahmadi Abdessadek , Tighilet Brahim , Besnard Stéphane , Chabbert Christian
Published: February 2024

The association between vestibular pathologies and thyroid hormone disorders has been known for several decades. However, very little information is available on the types of vestibular symptoms that may be affected by altered thyroid hormone levels. The aim of this study was to provide patient data in order to identify statistical associations between vestibular pathologies and thyroid hormone disorders. A retrospective review of the records of 422 patients seen for physiotherapy treatment of vertigo was carried out. Statistical analysis of the data was performed using logistic regression, providing Chi2 and Odds Ratio statistics. Our results show that hypothyroidism statistically significantly increases the expression of certain symptoms, such as vestibular instability and gait disorders, in vestibular pathologies such as Menière’s disease or central vertigo. By analyzing patient data, our study provides new evidence of dependence between altered thyroid status and the expression of vestibular pathologies.
Model Predictive Control of Counter-Rotating Motors for Underwater Vehicles Considering Unbalanced Load Variation
Authors: Zhang Shukuan , Nan Yunxiang , Zhang Yusen , Xiang Chuan , Vu Mai The
Published: February 2024

The propulsion system for underwater vehicles, driven by a counter-rotating permanent magnet synchronous motor (CRPMSM), can enhance the operational stability and efficiency of the vehicle. Due to the influence of complex underwater flows, the load imbalance of CRPMSM’s dual counter-rotating rotors may lead to severe issues of dual-rotor desynchronization rotation. Combining traditional vector control (VC) with master-slave control strategies can address the desynchronization problem when CRPMSM’s load changes. However, it results in significant speed fluctuations and a long transition time during the transition from load disturbance to synchronous rotation. This paper introduces a model predictive control (MPC) strategy to effectively resolve this issue. The incremental MPC model is established based on the mathematical model of CRPMSM in the dq coordinate system. The predictive control system forecasts the d- and q-axis components of stator currents for the next four control cycles. It selects the optimal control increments to minimize the cost function based on current predictions and different inverter voltage states. The obtained optimal d- and q-axis components of stator voltage are used to control CRPMSM under unbalanced load disturbances. Simulation results demonstrate that, compared to the VC strategy, CRPMSM utilizing the MPC strategy exhibits better dynamic performance with faster speed response and reduced torque fluctuations during load and speed variations.
Steering and Rising Testing of an Innovative Tourist Submarine
Authors: Ćatipović Ivan , Pedišić-Buča Marta , Parunov Joško
Published: February 2024

An innovative tourist submarine was studied by scale-model tests in a towing tank to determine its steering capabilities and detect motion instabilities during usual manoeuvres and emergency rising. Motion instabilities are caused by the combination of the submarine motions and the fluid flow, leading to excessive roll and pitch that can cause severe endangerment to passenger safety. The submarine model was built on a scale of 1:9. The model had six thrusters to conduct the tested manoeuvres, i.e., two main thrusters at the stern, two side thrusters, and two vertical thrusters. The thrusters were computer-controlled, so each thruster had a speed controller and could run forwards and backwards. Six different steering tests and four rising tests were conducted, with at least two runs per test. During the tests, the roll and pitch were measured. Lifting the submarine by a crane was also a part of the experimental campaign. In general, the steering capabilities of the submarine were satisfactory and rolling instabilities were absent. Just a few deficiencies in the steering capabilities were detected. The rising tests were performed without any major motion instabilities, but in one case, the final position of the model at the surface was unstable.
Simulation Study on Methods for Reducing Dynamic Cable Curvature in Floating Wind Power Platforms
Authors: Guo Zhitao , Zhao Xudong , Ma Qingfen , Li Jingru , Wu Zhongye
Published: February 2024

As a key component connecting a floating wind turbine with static sea cables, dynamic cables undergo significant tensile and bending loads caused by hydrostatic pressure, self-weight, waves, and ocean currents during service, which can lead to fatigue failure. Thus, dynamic and fatigue analyses are necessary for the design and operation of dynamic cables. In this study, a fatigue analysis of the three-core four-layer armored dynamic cable used in a semisubmersible floating wind turbine was carried out at a water depth of 25 m. The Miner linear cumulative damage method, based on material S-N curves, was used to predict fatigue life. The results indicate that, at 10 times the safety factor, the dynamic cables meet the design requirement of a 30-year service life in the studied marine environment. The maximal curvature of the dynamic cable always appears at the exit of the bend stiffener, even beyond the allowed point. Adding weights to the section where the cable exits the bend stiffener and adjusting the bend stiffener’s hanging angle can both reduce the curvature at the bend stiffener exit. The scheme of adjusting the bend stiffener’s hanging angle is preferred, for it is easier for simultaneous adjusting and inducing much smaller extra stress in the cable. As the hanging angle increases, the curvature at the bend stiffener exit decreases, while the maximal effective tension and maximal von Mises stress gradually increase. For certain operating conditions, especially with higher waves, it is better to adjust the hanging angle to avoid excessive curvature and, meanwhile, ensure the increase in the stress within a reasonable range.
Influence of Curved Video Laryngoscope Blade Sizes and Patient Heights on Video Laryngoscopic Views: A Randomized Controlled Trial
Authors: Kim Jong-Ho , Cheon Bo-Reum , Kim Hyesook , Hwang Sung-Mi , Lee Jae-Jun , Kwon Young-Suk
Published: February 2024

This study aimed to compare the video laryngoscope views facilitated by curved blades 3 and 4 with an exploration of the relationship between these views and patient height. Conducted as a randomized controlled trial, this study enrolled adults scheduled for surgery under general anesthesia. Intubation procedures were recorded, and the percentage of glottic opening was measured before tube insertion. Multivariate analysis validated the impact of various factors, including blade size and patient height, on the percentage of glottic opening scores. A total of 192 patients were included. The median percentage of glottic opening scores for curved blades 3 and 4 were 100 and 83, respectively (p < 0.001). The unstandardized coefficient indicated a significant negative impact of blade 4 on the percentage of glottic opening scores (−13, p < 0.001). In the locally estimated scatterplot smoothing analysis, blade 3 exhibited a steady rise in glottic opening scores with increasing height, whereas blade 4 showed a peak followed by a decline around 185 cm. The unstandardized coefficient of height showed no significant association (0, p = 0.819). The study observed superior laryngoscopic views with blade 3 compared to blade 4. However, no significant association was found between laryngoscopic views and patient height.
Regional Policies, Practices, Tools, and Strategies to Implement Polycentric Development: Comparative Case Studies of Portland, Seattle, and Denver
Authors: Ewing Reid , Lyons Torrey , Ameli Seyed Hassan , Hersey John , Kaniewska Justyna
Published: February 2024

Many of the larger US metropolitan regions promote polycentric development as a way of fostering livability, accessibility, and sustainability. Polycentric urban structures can increase transit ridership, promote active transportation, and decrease vehicle miles traveled (VMT) and CO2 emissions. Although many regions include ambitious polycentric aspirations in their plans, only a few follow up with rigorous implementation and see their efforts come to fruition. The topic of implementation is also widely omitted from scholarly inquiry. This research aims to explore three examples of successful implementation of urban polycentricity: Portland, Oregon; Seattle, Washington; and Denver, Colorado. Each region employs a very distinct polycentric development model, but each relies heavily on its regional governance organization for direction, guidance, and even command in the implementation process. To understand specific strategies and methods used by each region, the authors conducted interviews with metropolitan planning organizations, central cities, and transit agencies in the three regions and used qualitative techniques to analyze the interview transcripts and collected documents. As regional governance organizations play a crucial role in implementing regional plans, their policies and practices were also investigated by the authors. Based on collected data and insights, we conclude that the three regions are great examples of an advanced implementation of polycentric development. This research can be helpful to other US metropolitan regions that wish to promote polycentric development. The lessons learned from the three case studies can provide guidance and possible paths to successful implementation.
Multiphysics Study of Thermal Profiles and Residual Stress in Welding
Authors: Han Yousung
Published: February 2024

One of the effects of welding is residual stress. Welding involves complex tests concerning differences in values of the mechanical parameters of its regions as an effect of residual stress. Such multiphysics characteristics of welding pose a challenge in predicting residual stress. In the present study, a thermo-mechanical constitutive model considering phase transformation and transformation plasticity is implemented in the numerical model in ABAQUS user subroutines. In order to consider phase evolution in welding, the metallurgical parameters for Leblond’s phase equation were obtained from the calibration of DH36 steel with a CCT diagram. In addition, the effects of welding speed on thermal profiles and residual stress generation were investigated. Analysis has suggested that the width of the heat-affected zone (HAZ) decreases with an increase in welding speed, and the phase fraction is significantly affected by this kind of parameter. Such phase transformation has led to the generation of a compressive stress in the fusion zone (FZ) and HAZ. The volume difference between coexisting phases produces a compressive stress in cooling, and its magnitude was increased with martensite increasing.
The Influence of Thermal Parameters on the Self-Nucleation Behavior of Polyphenylene Sulfide (PPS) during Secondary Thermoforming
Authors: Ren Yi , Li Zhouyang , Li Xinguo , Su Jiayu , Li Yue , Gao Yu , Zhou Jianfeng , Ji Chengchang , Zhu Shu , Yu Muhuo
Published: February 2024

During the secondary thermoforming of carbon fiber-reinforced polyphenylene sulfide (CF/PPS) composites, a vital material for the aerospace field, varied thermal parameters profoundly influence the crystallization behavior of the PPS matrix. Notably, PPS exhibits a distinctive self-nucleation (SN) behavior during repeated thermal cycles. This behavior not only affects its crystallization but also impacts the processing and mechanical properties of PPS and CF/PPS composites. In this article, the effects of various parameters on the SN and non-isothermal crystallization behavior of PPS during two thermal cycles were systematically investigated by differential scanning calorimetry. It was found that the SN behavior was not affected by the cooling rate in the second thermal cycle. Furthermore, the lamellar annealing resulting from the heating process in both thermal cycles affected the temperature range for forming the special SN domain, because of the refined lamellar structure, and expelled various defects. Finally, this study indicated that to control the strong melt memory effect in the first thermal cycle, both the heating rate and processing melt temperature need to be controlled simultaneously. This work reveals that through collaborative control of these parameters, the crystalline morphology, crystallization temperature and crystallization rate in two thermal cycles are controlled. Furthermore, it presents a new perspective for controlling the crystallization behavior of the thermoplastic composite matrix during the secondary thermoforming process.
Fabrication of Two-Layer Aluminum Foam Consisting of Dissimilar Aluminum Alloys Using Optical Heating
Authors: Hangai Yoshihiko , Takagi Tatsuki , Goto Yu , Amagai Kenji
Published: February 2024

Aluminum foam is a lightweight material and has excellent shock-absorbing properties. Various properties of aluminum foam can be obtained by changing the base aluminum alloy. Multi-layer aluminum foam can be fabricated by varying the alloy type of the base aluminum alloy, but with different foaming temperatures, within a single aluminum foam to achieve multiple properties. In this study, we attempted to fabricate a two-layer aluminum foam with the upper layer of a commercially pure aluminum A1050 foam and the lower layer of an Al-Si-Cu aluminum alloy ADC12 foam by using an optical heating device that can heat from both the upper and lower sides. Two types of heating methods were investigated. One is to directly stack the A1050 precursor coated with black toner on top of the ADC12 precursor and to foam it from the top and bottom by optical heating. The other is to place a wire mesh between the ADC12 precursor and the A1050 precursor and place the A1050 precursor on the wire mesh, thereby creating a space between the precursors, which is then foamed by optical heating from the top and bottom. It was shown that both precursors can be foamed and joined, and a two-layer A1050/ADC12 foam can be fabricated for both types of heating methods. In the method in which two precursors were stacked and foamed, even if the light intensity of the halogen lamps on the top and bottom were adjusted, heat conduction occurred between the stacked precursors, and the foaming of each precursor could not be controlled, resulting in tilting of the joining interface. In the method of foaming using a wire mesh with a gap between two precursors, it was found that by adjusting the light intensity, the two precursors can be foamed almost simultaneously and achieve similar pore structures. The joining interface can also be maintained horizontally.
Bubble-Mediated Production of Few-Layer Graphene via Vapor–Liquid Reaction between Carbon Dioxide and Magnesium Melt
Authors: Li Xuejian , Wang Xiaojun , Shi Hailong , Jin Yuchao , Hu Xiaoshi , Xu Chao , Tang Lunyuan , Ma Min , Lu Liwei
Published: February 2024

It is urgent to develop novel technologies to convert carbon dioxide to graphene. In this work, a bubble-mediated approach via a chemical reaction between carbon dioxide gas and magnesium melt to fabricate a few-layer graphene was illustrated. The morphology and defects of graphene can be regulated by manipulating the melt temperature. The preparation of graphene at 720 °C exhibited an excellent quality of surface and graphitization degree. The high-quality few-layer graphene can be grown under the combined effect of carbon dioxide bubbles and in-situ grown MgO. This preparation method possesses the advantages of high efficiency, low cost, and environmental protection, which may provide a new strategy for the recovery and reuse of greenhouse gases.
Synthesis of New Chiral β-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation—Part I
Authors: Laskowska Anna , Pacuła-Miszewska Agata J. , Obieziurska-Fabisiak Magdalena , Jastrzębska Aneta , Długosz-Pokorska Angelika , Gach-Janczak Katarzyna , Ścianowski Jacek
Published: February 2024

A series of unsymmetrical phenyl β-carbonyl selenides with o-amido function substituted on the nitrogen atom with chiral alkyl groups was obtained. The compounds form a series of enantiomeric and diastereomeric pairs and present the first examples of this type of chiral Se derivatives. All obtained selenides were further evaluated as antioxidants and anticancer agents to define the influence of the particular stereochemistry of the attached functional groups on the bioactivity of the molecules. The highest H2O2 reduction potential was observed for N-(cis-2-hydroxy-1-indanyl)-2-((2-oxopropyl)selanyl)benzamide, and the best radical scavenging properties for N-(-1-hydroxy-2-butanyl)-2-((2-oxopropyl)selanyl)benzamide. Also, both enantiomers of the N-(1-hydroxy-2-butanyl) selenide expressed the highest cytotoxic potential towards human promyelocytic leukemia HL-60 cell line with similar IC50 values 14.4 ± 0.5 and 16.2 ± 1.1 µM, respectively. On the other hand, breast cancer cell line MCF-7 was most sensitive to N-((R)-(-)-1-hydroxy-2-butanyl)- 2-((2-oxopropyl)selanyl)benzamide (IC50 of 35.7 ± 0.6 µM). The structure–activity dependence of the obtained Se derivatives was discussed, and the most potent compounds were selected.
Tailoring Multiple Strengthening Phases to Achieve Superior High-Temperature Strength in Cast Mg-RE-Ag Alloys
Authors: Zhao Sicong , Guo Erjun , Liu Kun , Li Jingfang , Liu Jianhua , Li Mingyang
Published: February 2024

Mg alloys with excellent high-temperature mechanical properties are urgently desired to meet the design requirements of new-generation aircraft. Herein, novel cast Mg-10Gd-2Y-0.4Zn-0.2Ca-0.5Zr-xAg alloys were designed and prepared according to the advantages of multi-component alloying. The SEM and XRD results revealed that the as-cast microstructures contained α-Mg grains, β, and Zr-containing phase. As Ag rose from 0 wt.% to 2.0 wt.%, the grain size was refined from 40.7 μm to 33.5 μm, and the β phase significantly increased. The TEM observations revealed that the nano-scaled γ′ phase could be induced to precipitate in the α-Mg matrix by the addition of Ag. The stacking sequence of lamellar γ′ phases is ABCA. The multiple strengthening phases, including β phase, γ′ phases, and Zr-containing particles, were effectively tailored through alloying and synergistically enhanced the mechanical properties. The ultimate tensile strength increased from 154.0 ± 3.5 MPa to 231.0 ± 4.0 MPa at 548 K when Ag was added from 0 to 2.0 wt.%. Compared to the Ag-free alloy, the as-cast alloy containing 2.0 wt.% Ag exhibited a minor reduction in ultimate tensile strength (7.0 ± 4.0 MPa) from 498 K to 548 K. The excellent high-temperature performance of the newly developed Mg-RE-Ag alloy has great value in promoting the use of Mg alloys in aviation industries.
Performance and Interfacial Microstructure of Al/Steel Joints Welded by Resistance Element Welding
Authors: Wang Nannan , Li Jinpeng , Wu Wenjie , Bao Xiaohui , Ren Kexu , Zhao Jianghui , Yao Huai , Qiu Ranfeng
Published: February 2024

In this study, an upper sheet of an A6061 aluminum alloy and a lower sheet of Q235 steel were welded by resistance element welding with a steel rivet. The temperature field during welding was calculated using ABAQUS numerical simulation software, and the interfacial microstructure was observed. A nugget was formed between the rivet shank and the lower sheet. With increases in welding current and welding time, the tensile shear load of the joint increased first and then decreased slightly. When the welding current was 14 kA and the welding time was 300 ms, the tensile shear load of the joint reached a maximum of 7.93 kN. The smaller the distance from the position to the lower sheet along the interface between the rivet shank and upper sheet, the longer the high-temperature duration and the higher the peak temperature during welding. At the junction of the rivet shank, upper sheet, and lower sheet in the joint, the high-temperature duration was the longest, at about 392 ms, and the peak temperature was the highest, at about 1237 °C. The results show that the smaller the distance from the position to the lower sheet along the interface between the rivet shank and the upper sheet in the joint, the thicker the reaction layer generated there, and that the thickness of the reaction layer was about 2.0 μm at the junction of the rivet shank, upper sheet, and lower sheet in the joint.
Analysis of the Uniformity of Mechanical Properties along the Length of Wire Rod Designed for Further Cold Plastic Working Processes for Selected Parameters of Thermoplastic Processing
Authors: Laber Konrad Błażej
Published: February 2024

This study presents the results of research, the aim of which was to analyze the uniformity of the distribution of selected mechanical properties along the length of a 5.5 mm diameter wire rod of 20MnB4 steel for specific thermoplastic processing parameters. The scope of the study included, inter alia, metallographic analyses, microhardness tests, thermovision investigations, and tests of the wire rod mechanical properties (yield strength, ultimate tensile strength, elongation, relative reduction in area at fracture), along with their statistical analysis, for three technological variants of the rolling process differing by rolling temperature in the final stage of the rolling process (Reducing Sizing Mill rolling block [RSM]) and by cooling rate using STELMOR® cooling process. The obtained results led to the conclusion that the analyzed rolling process is characterized by a certain disparity of the analyzed mechanical properties along the length of the wire rod, which, however, retains a certain stability. This disparateness is caused by a number of factors. One of them, which ultimately determines the properties of the finished wire rod, is the process of controlled cooling in the STELMOR® line. Despite technological advances concerning technical solutions (among them, increasing the roller track speed in particular sections), it is currently not possible to completely eliminate the temperature difference along the length of the wire rod caused by the contact of individual coils with each other. From this point of view, for the analyzed thermoplastic processing parameters, there is no significant impact by the production process parameters on the quality of the finished steel product. Whereas, while comparing the mechanical properties and microstructure of the wire rod produced in the different technological combinations, it was found that the wire rod rolled in an RSM block at 850 °C and cooled after the rolling process on a roller conveyor at 10 °C/s had the best set of mechanical properties and the smallest microstructure variations. The wire rod produced in this way had the required level of plasticity reserve, which enables further deformation of the given type of steel in compression tests with a relative plastic strain of 75%. The uniformity of mechanical properties along the length of wire rods designed for further cold plastic working processes is an important problem. This is an important issue, given that wire rods made from 20MnB4 steel are an input material for further cold plastic working processes, e.g., for the drawing processes or the production of nails.
Durability of Concrete with Superabsorbent Polymer (SAP) Assessed Using Depth of Carbonation and NDT Ultrasonic Methods
Authors: Sokołowska Joanna Julia
Published: February 2024

The paper concerns destructive and non-destructive (NDT) evaluation of the effect of the addition of superabsorbent polymer (SAP) used as a carrier of mixing water and a means of internal curing on the durability of concrete. The research concerns testing of five concretes—an ordinary reference concrete and four concretes differing in the content of mixing water introduced into the concrete mix in the form of pre-saturated SAP particles (25%, two variants of 50% and 75% of the total mixing water in the form of SAP hydrogel). The research consisted of 4 stages of tests. The subsequent stages involved the analysis of the effect of using SAP as a carrier of mixing water on the particular characteristics of concrete mix and hardened concrete, i.e., consistency and density of concrete mix (1st stage), carbonation tested using two indicators—phenolphthalein and thymol phenolphthalein (2nd stage), and finally: the homogeneity of the concretes’ structure by means of ultrasonic method (determination of ultrasonic pulse velocity) 28 days after production (3rd stage) and 3 years after production (4th stage). The ultrasonic pulse (or wave) velocity was then correlated with the content of water applied in the form of SAP hydrogel. The statistical analysis of results showed that the method of introducing the mixing water into the concrete mix in the form of pre-absorbed superabsorbent polymer, although it changed the concrete mix consistency, did not significantly affect the concrete ability to resist carbonation. Meanwhile, after 3 years, the densification of the microstructure of concrete with SAP has been observed.
Improving Risk Assessment Model for Cyber Security Using Robust Aggregation Operators for Bipolar Complex Fuzzy Soft Inference Systems
Authors: Ali Zeeshan , Yang Miin-Shen
Published: February 2024

Improving a risk assessment technique for the problem of cyber security is required to modify the technique’s capability to identify, evaluate, assess, and mitigate potential cyber threats and ambiguities. The major theme of this paper is to find the best strategy to improve and refine the cyber security risk assessment model. For this, we compute some operational laws for bipolar complex fuzzy soft (BCFS) sets and then propose the BCFS weighted averaging (BCFSWA) operator, BCFS ordered weighted averaging (BCFSOWA) operator, BCFS weighted geometric (BCFSWG) operator, and BCFS ordered weighted geometric (BCFSOWG) operator. Furthermore, we give their properties, such as idempotency, monotonicity, and boundedness. Additionally, we improve the risk assessment technique for the cyber security model based on the proposed operators. We illustrate the technique of multi-attribute decision-making (MADM) problems for the derived operators based on BCFS information. Finally, we compare our ranking results with those of some existing operators for evaluating and addressing the supremacy, validity, and efficiency of these operators under BCFS information.
Novel Robust Stability Criteria for Lur’e Systems with Time-Varying Delay
Authors: Wang Wei , Liang Jinming , Liu Mihan , Ding Liming , Zeng Hongbing
Published: February 2024

This paper focuses on addressing the issue of absolute stability for uncertain Lur’e systems with time-varying delay using a delay-segmentation approach. The approach involves decomposing the delay interval into two distinct subintervals of unequal lengths. This allows for the introduction of a delay-segmentation-based augmented Lyapunov–Krasovskii functional that ensures piecewise continuity at the partition points. By selecting two sets of Lyapunov matrices for the time-varying delay in each interval, the obtained results are less conservative, providing a more accurate assessment of absolute stability. Finally, a numerical example is given to demonstrate the superiority of the delay-segmentation approach.
Predicting the Feasibility of Curative Resection in Low Rectal Cancer: Insights from a Prospective Observational Study on Preoperative Magnetic Resonance Imaging Accuracy
Authors: Volovat Cristian-Constantin , Scripcariu Dragos-Viorel , Boboc Diana , Volovat Simona-Ruxandra , Vasilache Ingrid-Andrada , Lupascu-Ursulescu Corina , Gheorghe Liliana , Baean Luiza-Maria , Volovat Constantin , Scripcariu Viorel
Published: February 2024

Background and Objectives: A positive pathological circumferential resection margin is a key prognostic factor in rectal cancer surgery. The point of this prospective study was to see how well different MRI parameters could predict a positive pathological circumferential resection margin (pCRM) in people who had been diagnosed with rectal adenocarcinoma, either on their own or when used together. Materials and Methods: Between November 2019 and February 2023, a total of 112 patients were enrolled in this prospective study and followed up for a 36-month period. MRI predictors such as circumferential resection margin (mCRM), presence of extramural venous invasion (mrEMVI), tumor location, and the distance between the tumor and anal verge, taken individually or combined, were evaluated with univariate and sensitivity analyses. Survival estimates in relation to a pCRM status were also determined using Kaplan–Meier analysis. Results: When individually evaluated, the best MRI predictor for the detection of a pCRM in the postsurgical histopathological examination is mrEMVI, which achieved a sensitivity (Se) of 77.78%, a specificity (Sp) of 87.38%, a negative predictive value (NPV) of 97.83%, and an accuracy of 86.61%. Also, the best predictive performance was achieved by a model that comprised all MRI predictors (mCRM+ mrEMVI+ anterior location+ < 4 cm from the anal verge), with an Se of 66.67%, an Sp of 88.46%, an NPV of 96.84%, and an accuracy of 86.73%. The survival rates were significantly higher in the pCRM-negative group (p < 0.001). Conclusions: The use of selective individual imaging predictors or combined models could be useful for the prediction of positive pCRM and risk stratification for local recurrence or distant metastasis.
Effects of Aging Treatments on the Age Hardening Behavior and Microstructures in an Al-Mg-Si-Cu Alloy
Authors: Liu Limei , Hou Yingpeng , Ye Tuo , Zhang Like , Huang Xuan , Gong Yuqing , Liu Chao , Wu Yuanzhi , Duan Shiyun
Published: February 2024

In this study, we investigated the effects of modified aging treatments on the microstructures and hardness in a commercial 6016 Al alloy through hardness tests and transmission electron microscopy (TEM) observations. The results demonstrate that many fine needle-like β″ phases contribute to the high hardness of peak-aged (T6) alloys. Over-aging treatments lead to the precipitation of lath-like β′, β″/disordered, or B′/disordered composite phases. Moderate over-aging treatment results in the coarsening of grain boundary precipitates (GBPs) and widening of the precipitate-free zone (PFZ), while heavy over-aging treatment triggers the re-precipitation of Cu-containing GBPs and increases the number density of GBPs. A retrogression and re-aging (RRA) treatment precipitates β″, lath-like β′, and disordered phases, while a two-step aging (T78) treatment precipitates β″, B′, and disordered phases. Both the T78 and the RRA treatments lead to the coarsening of GBPs and the widening of PFZs. The decreased hardness during over-aging treatments is attributed to a combination of coarsening intragranular precipitates and/or wider PFZs. The T78 and RRA tempers achieve 95.5% and 94% of the hardness values of the T6 treatment, respectively. The hardness values of the RRA and T78 treated alloys are related to the finer nano-sized precipitates formed during the high temperature process. These precipitates can compensate for the loss of hardness caused by the increase in the widths of the PFZs and the coarsening of the matrix precipitates. The relationship between the hardness and microstructures such as PFZs and precipitates in the matrix during various heat treatments is elucidated.
Stereo Visual Servoing Control of a Soft Endoscope for Upper Gastrointestinal Endoscopic Submucosal Dissection
Authors: Chen Jian , Wang Shuai , Zhao Qingxiang , Huang Wei , Chen Mingcong , Hu Jian , Wang Yihe , Liu Hongbin
Published: February 2024

Quickly and accurately completing endoscopic submucosal dissection (ESD) operations within narrow lumens is currently challenging because of the environment’s high flexibility, invisible collision, and natural tissue motion. This paper proposes a novel stereo visual servoing control for a dual-segment robotic endoscope (DSRE) for ESD surgery. Departing from conventional monocular-based methods, our DSRE leverages stereoscopic imaging to rapidly extract precise depth data, enabling quicker controller convergence and enhanced surgical accuracy. The system’s dual-segment configuration enables agile maneuverability around lesions, while its compliant structure ensures adaptability within the surgical environment. The implemented stereo visual servo controller uses image features for real-time feedback and dynamically updates gain coefficients, facilitating rapid convergence to the target. In visual servoing experiments, the controller demonstrated strong performance across various tasks. Even when subjected to unknown external forces, the controller maintained robust performance in target tracking. The feasibility and effectiveness of the DSRE were further verified through ex vivo experiments. We posit that this novel system holds significant potential for clinical application in ESD surgeries.
Influence of Process Energy on the Formation of Imperfections in Body-Centered Cubic Cells with Struts in the Vertical Orientation Produced by Laser Powder Bed Fusion from the Magnesium Alloy WE43
Authors: Jaroš Jan , Vaverka Ondřej , Senck Sascha , Koutný Daniel
Published: February 2024

The low specific density and good strength-to-weight ratio make magnesium alloys a promising material for lightweight applications. The combination of the properties of magnesium alloys and Additive Manufacturing by the Laser Powder Bed Fusion (LPBF) process enables the production of complex geometries such as lattice or bionic structures. Magnesium structures are intended to drastically reduce the weight of components and enable a reduction in fuel consumption, particularly in the aerospace and automotive industries. However, the LPBF processing of magnesium structures is a challenge. In order to produce high-quality structures, the process parameters must be developed in such a way that imperfections such as porosity, high surface roughness and dimensional inaccuracy are suppressed. In this study, the contour scanning strategy is used to produce vertical and inclined struts with diameters ranging from 0.5 to 3 mm. The combination of process parameters such as laser power, laser speed and overlap depend on the inclination and diameter of the strut. The process parameters with an area energy of 1.15–1.46 J/mm2 for struts with a diameter of 0.5 mm and an area energy of 1.62–3.69 J/mm2 for diameters of 1, 2 and 3 mm achieve a relative material density of 99.2 to 99.6%, measured on the metallographic sections. The results are verified by CT analyses of BCCZ cells, which achieve a relative material density of over 99.3%. The influence of the process parameters on the quality of struts is described and discussed.
Metagenomic Analysis of Antarctic Ocean near the King Sejong Station Reveals the Diversity of Carotenoid Biosynthetic Genes
Authors: Cho Woo Yeon , Lee Pyung Cheon
Published: February 2024

Carotenoids, biotechnologically significant pigments, play crucial biological roles in marine microorganisms. While various environments have been explored to understand the diversity of carotenoids and their biosynthesis, the Antarctic Ocean remains relatively under-investigated. This study conducted a metagenomic analysis of seawater from two depths (16 and 25 m) near the King Sejong Station in the Antarctic Ocean. The analysis revealed a rich genetic diversity underlying C40 (astaxanthin, myxol, okenone, spheroidene, and spirilloxanthin), C30 (diaponeurosporene, diapolycopene, and staphyloxanthin), and C50 (C.p. 450) carotenoid biosynthesis in marine microorganisms, with notable differential gene abundances between depth locations. Exploring carotenoid pathway genes offers the potential for discovering diverse carotenoid structures of biotechnological value and better understanding their roles in individual microorganisms and broader ecosystems.
The Temporal Distribution of the Host Rocks to Gold, the Archean Witwatersrand Basin, South Africa
Authors: Phillips Neil , Vearncombe Julian , Craw Dave , Day Arthur
Published: February 2024

The hosts to gold around the Witwatersrand Basin span over 400 my, through 14 km of stratigraphy in a variety of host rocks and in tectonic settings that include periods of rifting, thermal subsidence, foreland basin, flood basalt outpouring, graben development, and further thermal subsidence. A geological model that assumes placer processes to explain this diversity implies a super-long-lived and special source of the detrital gold, transport, and highly effective sorting processes over a time span of 400 my. There is no evidence of a special source and sorting over such a long time period. In the Phanerozoic, this would be equivalent to the special source and sorting processes operating continually over an equivalent period of geological time spanning from the Devonian up until the present day; this is as yet recognised nowhere else on the planet. With regard to the geological model that assumes a placer process, this is untenable because of these scientific shortcomings and its lack of success in exploration. A better use of funds may be to consider alternative approaches and epigenetic models in exploration.
Stress–Strength Reliability of the Type P(X < Y) for Birnbaum–Saunders Components: A General Result, Simulations and Real Data Set Applications
Authors: Quintino Felipe S. , Ozelim Luan Carlos de Sena Monteiro , Fonseca Tiago A. da , Rathie Pushpa Narayan
Published: February 2024

An exact expression for R=P(X<Y) has been obtained when X and Y are independent and follow Birnbaum–Saunders (BS) distributions. Using some special functions, it was possible to express R analytically with minimal parameter restrictions. Monte Carlo simulations and two applications considering real datasets were carried out to show the performance of the BS models in reliability scenarios. The new expressions are accurate and easy to use, making the results of interest to practitioners using BS models.
Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species
Authors: Li Zhongyuan , Chen Yunyan , Li Liang , Xue Mei , Feng Li
Published: February 2024

Swine enteric coronaviruses (SECoVs), including porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), have caused high mortality in piglets and, therefore, pose serious threats to the pork industry. Coronaviruses exhibit a trend of interspecies transmission, and understanding the host range of SECoVs is crucial for improving our ability to predict and control future epidemics. Here, the replication of PDCoV, TGEV, and PEDV in cells from different host species was compared by measuring viral genomic RNA transcription and protein synthesis. We demonstrated that PDCoV had a higher efficiency in infecting human lung adenocarcinoma cells (A549), Madin–Darby bovine kidney cells (MDBK), Madin–Darby canine kidney cells (MDCK), and chicken embryonic fibroblast cells (DF-1) than PEDV and TGEV. Moreover, trypsin can enhance the infectivity of PDCoV to MDCK cells that are nonsusceptible to TGEV. Additionally, structural analyses of the receptor ectodomain indicate that PDCoV S1 engages Aminopeptidase N (APN) via domain II, which is highly conserved among animal species of different vertebrates. Our findings provide a basis for understanding the interspecies transmission potential of these three porcine coronaviruses.
Disposition of Hexahydrocannabinol Epimers and Their Metabolites in Biological Matrices following a Single Administration of Smoked Hexahydrocannabinol: A Preliminary Study
Authors: Di Trana Annagiulia , Di Giorgi Alessandro , Sprega Giorgia , Carlier Jeremy , Kobidze Giorgi , Montanari Eva , Taoussi Omayema , Bambagiotti Giulia , Fede Maria Sofia , Lo Faro Alfredo Fabrizio , Tini Anastasio , Busardò Francesco Paolo , Pichini Simona
Published: February 2024

In 2023, hexahydrocannabinol (HHC) attracted the attention of international agencies due to its rapid spread in the illegal market. Although it was discovered in 1940, less is known about the pharmacology of its two naturally occurring epimers, 9(R)-HHC and 9(S)-HHC. Thus, we aimed to investigate the disposition of hexahydrocannabinol epimers and their metabolites in whole blood, urine and oral fluid following a single controlled administration of a 50:50 mixture of 9(R)-HHC and 9(S)-HHC smoked with tobacco. To this end, six non-user volunteers smoked 25 mg of the HHC mixture in 500 mg of tobacco. Blood and oral fluid were sampled at different time points up to 3 h after the intake, while urine was collected between 0 and 2 h and between 2 and 6 h. The samples were analyzed with a validated HPLC-MS/MS method to quantify 9(R)-HHC, 9(S)-HHC and eight metabolites. 9(R)-HHC showed the highest Cmax and AUC0–3h in all the investigated matrices, with an average concentration 3-fold higher than that of 9(S)-HHC. In oral fluid, no metabolites were detected, while they were observed as glucuronides in urine and blood, but with different profiles. Indeed, 11nor-9(R)-HHC was the most abundant metabolite in blood, while 8(R)OH-9(R) HHC was the most prevalent in urine. Interestingly, 11nor 9(S) COOH HHC was detected only in blood, whereas 8(S)OH-9(S) HHC was detected only in urine.
Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[11C]Methionine and [11C]Choline
Authors: Mallapura Hemantha , Tanguy Laurent , Mahfuz Samin , Bylund Lovisa , Långström Bengt , Halldin Christer , Nag Sangram
Published: February 2024

Microfluidic technology is a highly efficient technique used in positron emission tomography (PET) radiochemical synthesis. This approach enables the precise control of reactant flows and reaction conditions, leading to improved yields and reduced synthesis time. The synthesis of two radiotracers, L-[11C]methionine and [11C]choline, was performed, using a microfluidic cassette and an iMiDEVTM module by employing a dose-on-demand approach for the synthesis process. We focused on optimizing the precursor amounts and radiosynthesis on the microfluidic cassette. L-[11C]methionine and [11C]choline were synthesized using a microreactor filled with a suitable resin for the radiochemical reaction. Trapping of the [11C]methyl iodide, its reaction, and solid-phase extraction purification were performed on a microreactor, achieving radiochemical yields of >80% for L-[11C]methionine and >60% for [11C]choline (n = 3). The total synthesis time for both the radiotracers was approximately 20 min. All quality control tests complied with the European Pharmacopeia standards. The dose-on-demand model allows for real-time adaptation to patient schedules, making it suitable for preclinical and clinical settings. Precursor optimization enhanced the cost efficiency without compromising the yield. The importance of dose-on-demand synthesis and optimized precursor utilization to produce L-[11C]methionine and [11C]choline was emphasized in this study. The results demonstrated the feasibility of dose-on-demand adaptations for clinical applications with reduced precursor quantities and high radiochemical yields.
Immune Checkpoint Inhibitors and Lupus Erythematosus
Authors: Vitzthum von Eckstaedt Hans , Singh Arohi , Reid Pankti , Trotter Kimberly
Published: February 2024

Immune checkpoint inhibitors (ICIs) are the standard of care for a growing number of malignancies. Unfortunately, they are associated with a broad range of unique toxicities that mimic the presentations of primary autoimmune conditions. These adverse events are termed immune-related adverse events (irAEs), of which ICI-lupus erythematosus (ICI-LE) constitutes a small percentage. Our review aims to describe the available literature on ICI-LE and ICI treatment for patients with pre-existing lupus. Most diagnoses of ICI-LE had findings of only cutaneous lupus; four diagnoses of ICI-LE had systemic lupus manifestations. Over 90% (27 of 29) of cases received anti-PD-1/PDL-1 monotherapy, 1 received combination therapy, and 1 received only anti-CTLA-4 treatment. About three-fourths (22 of 29 or 76%) of patients with ICI-lupus were managed with topical steroids, 13 (45%) received hydroxychloroquine, and 10 (34%) required oral corticosteroids. In our case series, none of the patients with pre-existing lupus receiving ICI therapy for cancer had a flare of their lupus, but few had de novo irAE manifestations, all of which were characterized as low-grade. The review of the literature yielded seven ICI-LE flares from a total of 27 patients with pre-existing lupus who received ICI. Most flares were manageable without need for ICI cessation.