bluuebunny/crossref_metadata_2025 huggingface dataset:
Justice and Restitution in Post-Nazi Romania
Authors: Ionescu Stefan Cristian
Published: January 2025

On 23rd August 1944, following the collapse of the pro-Nazi dictatorship of Ion Antonescu, Romania changed sides and abandoned the Axis to join the Allies. Justice and Restitution in Post-Nazi Romania explores the hopes, struggles and disappointments of Jewish communities in Romania seeking to rebuild their lives after the Holocaust. Focusing on the efforts of survivors to recuperate rights and property, Stefan Cristian Ionescu demonstrates how the early transitional government enabled short term restitution. However, from 1948, the consolidated communist regime implemented nationalizations which dispossessed many citizens. Jewish communities were disproportionality affected, and real estate and many businesses were lost once again. Drawing on archival sources from government documentation to diaries and newspaper reports, this study explores both the early success and later reversal of restitution policies. In doing so, it sheds light on the postwar treatment of Romanian Jewish survivors, and the reasons so many survivors emigrated from Romania.
Exploitation, Human Rights and Corporate Obligations
Authors: Berkey Brian
Published: January 2025

In this paper, I argue that there is an inconsistency between the content of some of the labour-related human rights articulated in documents such as the Universal Declaration of Human Rights and the International Covenant on Economic, Social and Cultural Rights and the obligations ascribed to various actors regarding those rights in the United Nations (UN) Guiding Principles on Business and Human Rights (UNGPs), in particular those ascribed to corporations. Recognizing the inconsistency, I claim, can help us see some of the moral limitations of both familiar public responses to exploitative labour practices and influential philosophical accounts of the wrong of exploitation. In light of these limitations, I argue that there are reasons to accept a more expansive account of the human rights-related obligations of corporations than that found in the UNGPs, and in particular that we should accept that corporations have obligations to actively contribute to lifting people out of poverty.
Psychological Associations of Multiple Disasters: A Longitudinal Study of Adolescents in Puerto Rico
Authors: Chavez Ligia M. , García Pedro A. , Stimpson Jim P. , Vale Lassalle Keilyn M. , Saumell-Rivera Janet T. , Ortega Alexander N.
Published: January 2025

Objectives

Psychological reactions in response to disasters have been associated with increased mental health (MH) symptomatology, decreased quality of life (QOL), and post-traumatic stress (PTSD). This study provides a rare opportunity to examine post disaster MH longitudinally in a sample of adolescents.

Methods

From 2018-20, adolescents (12-18 years, N=228) were interviewed about disaster exposure, QOL using the Adolescent Quality of Life-Mental Health Scale (AQOL-MHS), psychological symptoms, and diagnoses.

Results

Having an MH diagnosis and PTSD are clear indicators of worse Emotional Regulation (ER) (P ≤ 0.03, P ≤ 0.0001) and Self-Concept (SC) (P ≤ 0.006, P ≤ 0.002) QOL. Girls were disproportionately affected in all models for SC and Social Context domains (P ≤ 0.0001, P ≤ 0.01). Interaction models results for ER (P ≤ 0.05) and SC (P ≤ 0.01) indicate that those with PTSD are improving over time at a greater rate than those without PTSD.

Conclusions

Recovery takes time and a clear sex disparity for girls was observed. Results for the different AQOL-MHS domains highlight how the challenges experienced by disasters are multifaceted. Knowing who is at greater risk can allow for better resource allocation and targeted population-based prevention strategies to promote and maintain MH and resolve risk factors for mental illnesses.
First Ruelle resonance for an Anosov flow with smooth potential
Authors: HUMBERT TRISTAN
Published: January 2025

We combine methods from microlocal analysis and dimension theory to study resonances with largest real part for an Anosov flow with smooth real valued potential. We show that the resonant states are closely related to special systems of measures supported on the stable manifolds introduced by Climenhaga [SRB and equilibrium measures via dimension theory. A Vision for Dynamics in the 21st Century: The Legacy of Anatole Katok. Cambridge University Press, Cambridge, 2024, pp. 94–138]. As a result, we relate the presence of the resonances on the critical axis to mixing properties of the flow with respect to certain equilibrium measures and show that these equilibrium measures can be reconstructed from the spectral theory of the Anosov flow.
Early intervention in psychosis programs in Africa, Asia and Latin America; challenges and recommendations
Authors: van der Ven Els , Yang Xinyu , Mascayano Franco , Weinreich Karl J , Chen Eric YH , Tang Charmaine YZ , Kim Sung-Wan , Burns Jonathan K , Chiliza Bonginkosi , Mohan Greeshma , Iyer Srividya N , Rangawsamy Thara , de Vries Ralph , Susser Ezra S
Published: January 2025

Background

While early intervention in psychosis (EIP) programs have been increasingly implemented across the globe, many initiatives from Africa, Asia and Latin America are not widely known. The aims of the current review are (a) to describe population-based and small-scale, single-site EIP programs in Africa, Asia and Latin America, (b) to examine the variability between programs located in low-and-middle income (LMIC) and high-income countries in similar regions and (c) to outline some of the challenges and provide recommendations to overcome existing obstacles.

Methods

EIP programs in Africa, Asia and Latin America were identified through experts from the different target regions. We performed a systematic search in Medline, Embase, APA PsycInfo, Web of Science and Scopus up to February 6, 2024.

Results

Most EIP programs in these continents are small-scale, single-site programs that serve a limited section of the population. Population-based programs with widespread coverage and programs integrated into primary health care are rare. In Africa, EIP programs are virtually absent. Mainland China is one of the only LMICs that has begun to take steps toward developing a population-based EIP program. High-income Asian countries (e.g. Hong Kong and Singapore) have well-developed, comprehensive programs for individuals with early psychosis, while others with similar economies (e.g. South Korea and Japan) do not. In Latin America, Chile is the only country in the process of providing population-based EIP care.

Conclusions

Financial resources and integration in mental health care, as well as the availability of epidemiological data on psychosis, impact the implementation of EIP programs. Given the major treatment gap of early psychosis in Africa, Latin America and large parts of Asia, publicly funded, locally-led and accessible community-based EIP care provision is urgently needed.
Direct statistical simulation using generalised cumulant expansions
Authors: Nivarti G.V. , Marston J.B. , Tobias S.M.
Published: January 2025

In recent years, the generalised quasilinear (GQL) approximation has been developed and its efficacy tested against purely quasilinear (QL) approximations. GQL systematically interpolates between QL and fully nonlinear dynamics by employing a generalised Reynolds decomposition. Here, we examine an exact statistical closure for the GQL equations on the doubly periodic

$\beta$

-plane. Closure is achieved at second order using a generalised cumulant approach which we term GCE2. GCE2 is shown to yield improved performance over statistical representations of purely QL dynamics (CE2) and thus enables direct statistical simulation of complex mean flows that do not entirely fall within the remit of pure QL theory. Despite the existence of an exact closure, GCE2 like CE2 admits the possibility of a rank instability that leads to differences with statistics obtained from GQL. Recognition of this instability is a necessary step before further progress can be made with the GCE2 statistical closure.
Female Leadership and Corporate Acquisitions in Chinese State-Owned Enterprises
Authors: Zhu Danyang , Li Xu-Hong
Published: January 2025

Research on female leadership has documented that female-led firms tend to engage in lower risk-taking activities than male-led firms and attributed it to females' higher propensity for risk aversion. Nevertheless, this claim and its associated findings have been increasingly challenged. In this article, we address the unclear pattern of females' risk preference in leadership by contextualizing the effect of chair gender on corporate acquisitions in the context of state-owned enterprises (SOEs) in China. Drawing on expectancy violation theory, we propose that female chairs are more inclined to take risks when they operate in contexts that encourage female agency. We further explore self-affirmation mechanisms through two moderators: gender stereotype threats and self-efficacy. An analysis of chairs of 1,265 publicly listed SOEs in China from 2008 to 2020 supports predictions that female chairs are more likely than male chairs to engage in firm acquisitions. The effects are amplified under low levels of female executive representation and high levels of political appointments held by female chairs. The study shows that context determines how extensively gender affects risk-taking. It offers new insights into when and why female leaders exhibit higher levels of risk-taking in Chinese SOEs.
Orbit determination of visual binary systems observed with CST telescope in 2010–2013
Authors: Rica Francisco , Barrena Rafael , Henríquez Juan Antonio , Vázquez Gabriel , Vázquez Carlos , Hernández David , del Rosario Jorge Luis
Published: January 2025

We present new orbital solutions for 15 binaries, which were astrometrically measured by our team during 2010–2013, using the FastCam ‘lucky-imaging’ camera installed at the 1.5-m Carlos Sánchez Telescope (CST) at the Observatorio del Teide, Tenerife (Spain). We present first orbital solutions for BU 1292, STF 147, HDS 1898, and STT 325 and revise orbital solutions for AG 14, D 5 AB, A 1581, HO 525 AB, WOR 19, A 1999, HU 572, HU 742, COU 227, BU 696 AB, and A 893. We apply two orbital calculation techniques, the ‘three-dimensional grid search method’, first described by Hartkopf, McAlister, & Franz (1989), and the Docobo’s analytical method (Docobo 1985). We use our tool ‘Binary Deblending’, based on deblending the entire observed multiband photometry into fundamental and photometric parameters for each stellar component based on PARSEC isochrones. We also obatain the total mass for all systems. Our findings include the identification of a binary system consisting of two M-type dwarfs (WOR 19), a binary of evolved components (twin F6IV-V stars) in BU 1292, accompanied by a newly discovered wide (10.5") and faint companion with G = 17.05 mag. Additionally, we explore the X-ray emission system STF 147 and a very young quadruple system, WDS 04573+5345. This comprehensive analysis significantly contributes to our understanding of the formation and evolution of stellar systems.
Late Neoarchaean tectonic environment in the Anshan-Benxi area: evidence of metamorphic supracrustal rocks
Authors: Fan Guoyu , Dong Xiaojie , Zhu Kai , Liu Zhenghong , Xu Zhongyuan , Zhao Qingying
Published: January 2025

Zircon U-Pb geochronology, geochemistry and Hf isotope analysis of supracrustal rocks in the Anshan-Benxi area in the northeastern part of the North China Craton can help constrain their petrogenesis and tectonic background, providing evidence for a further investigation of the late Neoarchaean tectonic environment in the Anshan-Benxi area. The primary rock types observed among the supracrustal rocks in the Anshan-Benxi area comprise amphibolite, metamorphic rhyolite, metamorphic sandstone, chlorite schist, actinolite schist, among others. SHRIMP zircon U-Pb dating indicates that magmatic zircons from the amphibolite (GCN-1) formed at 2553 ± 18Ma. Similarly, LA-ICP-MS zircon U-Pb dating reveals that magmatic zircons from the metamorphic rhyolite (G2304-1) were formed at 2457 ± 35Ma. The peak age of the metamorphic sandstone is determined to be approximately 2500Ma, suggesting that the supracrustal rocks in the Anshan-Benxi area originated in the late Neoarchaean. The protoliths of sericite quartz schist and metamorphic rhyolite are identified as rhyolitic volcanic rocks, displaying a right-leaning distribution pattern of rare earth elements (REEs). On the other hand, actinolite schist, chlorite schist and amphibolite are classified as basaltic volcanic rocks, exhibiting a flat REE pattern with a weak negative Eu anomaly. The εHf(t) value of metamorphic rhyolite ranges between -1.19 and -1.47, with a two- stage depleted mantle model age of tDM2(Ma) = 2922–3132 Ma. The protolith magma of sericite quartz schist and metamorphic rhyolite originates from partial melting of 3.0Ga basaltic crust, while the source of actinolite schist, chlorite schist and amphibolite are mainly derived from the mantle. In summary, the findings suggest that plate already existed in the late Neoarchaean or earlier, with magmatism in the Anshan-Benxi area likely occurring within an arc tectonic environment linked to plate subduction.
Short communication: Exploring gastrointestinal tract nemabiomes in captive ungulates at the SANBI National Zoological Gardens: A next-generation sequencing baseline approach
Authors: Phetla V. , Masenya K. , Chaisi M.
Published: January 2025

Gastrointestinal tract (GIT) nematode infections have a significant negative impact on the well-being and productivity of animals. While it is common for a host to be co-infected with multiple species of nematode parasites simultaneously, there is a lack of effective tools to study the composition of these complex parasite communities. We describe the application of the “nemabiome” amplicon sequencing to study parasitic GIT nematode communities in captive wildlife at the National Zoological Garden, South African National Biodiversity Institute. A total of 13 samples from Roan antelope (n=1), Eland (n=1), Sable antelope (n=9), Arabian oryx (n=1), and Blue duiker (n=1) were analysed for the presence of GIT nematode infections. A total of 256 operational taxonomical units (OTUs) were generated and compared to a curated database with ≥99% identity to sequences in the NCBI database. The OTUs found represented nematode species which are commonly associated with wild ruminants. These belonged to members of the genera Haemonchus, Trichostrongylus, and Cooperia, with a few OTUs classified as unidentified genera detected. These were further classified to species level, with Haemonchus contortus and Trichostrongylus colubriformis having high relative abundance across all captive ungulate species. Utilizing amplicon sequencing to examine the nemabiome holds great potential for enhancing our basic knowledge of the biology of gastrointestinal nematodes and monitoring infections. This improved understanding could guide the development of more efficacious preventive and control measures against these significant parasites, which negatively impact animal health and productivity on a global scale.
Diversity of trematodes (Platyhelminthes) in Mexico with an assessment of the availability of genetic data for their conservation
Authors: Velázquez-Urrieta Y. , Mendoza-Portillo V. , García-De León F. J.
Published: January 2025

Trematodes are one of the most abundant and diverse groups of platyhelminths. They parasitize all major groups of vertebrates as definitive hosts and therefore play an important role in ecosystem composition. It is estimated that 18,000 to 25,000 species of trematodes exist worldwide, of which 685 have been reported in Mexico. Although this group is an integral part of ecosystems, there are still no studies that highlight the importance of parasites, especially in conservation approaches. Here, we recompiled information on the occurrence and available genetic data of trematodes in Mexico to estimate the specific richness of their representation across the Protected Areas (PAs) and provinces of Mexico. We consulted national and international databases (e.g., GBIF, CONABIO, CNHE-UNAM) and genetic repositories (e.g., GenBank) to generate curated datasets. We obtained 6,780 records that represent 99% of species reported in Mexico (680 species), of which only 10.2% are included in PAs. For genetic data, we found information from five nuclear regions (28S, 18S, ITS1, ITS2 and 5.8S) and two mitochondrial genes (COI and NAD1) for 118 species, of which only 3.5% were associated with PAs. With these results, we provide a spatial distribution of records (occurrence and genetic data) of trematodes present in Mexico and its PAs and identify poorly represented biogeographic provinces (e.g., Sierra Madre del Sur). We also highlight that this is the first study in Mexico to include this group in a conservation approach, and we record valuable information for future studies.
Cellular and extracellular white matter alterations after childhood trauma experience in individuals with schizophrenia
Authors: Dauvermann Maria R. , Costello Laura , Tronchin Giulia , Corley Emma , Holleran Laurena , Mothersill David , Rokita Karolina I. , Kane Ruán , Hallahan Brian , McDonald Colm , Pasternak Ofer , Donohoe Gary , Cannon Dara M.
Published: January 2025

Background

Childhood trauma (CT) is related to altered fractional anisotropy (FA) in individuals with schizophrenia (SZ). However, it remains unclear whether CT may influence specific cellular or extracellular compartments of FA in SZ with CT experience. We extended our previous study on FA in SZ (Costello et al., 2023) and examined the impact of CT on hypothesized lower free water-corrected FA (FAT) and higher extracellular free water (FW).

Method

Thirty-seven SZ and 129 healthy controls (HC) were grouped into the ‘none/low’ or ‘high’ CT group. All participants underwent diffusion-weighted magnetic resonance imaging. We performed tract-based spatial statistics to study the main effects of diagnostic group and CT, and the interaction between CT and diagnostic group across FAT and FW.

Results

SZ displayed lower FAT within the corpus callosum and corona radiata compared to HC (p < 0.05, Threshold-Free Cluster Enhancement (TFCE)). Independent of diagnosis, we observed lower FAT (p < 0.05, TFCE) and higher FW (p < 0.05, TFCE) in both SZ and HC with high CT levels compared to SZ and HC with none or low CT levels. Furthermore, we did not identify an interaction between CT and diagnostic group (p > 0.05, TFCE).

Conclusions

These novel findings suggest that the impact of CT on lower FAT may reflect cellular rather than extracellular alterations in established schizophrenia. This highlights the impact of CT on white matter microstructure, regardless of diagnostic status.
Prospective study of peripartum group B streptococcus colonization in Japanese mothers and neonates
Authors: Yoshida Emiko , Takeda Jun , Maruyama Yojiro , Suga Naoko , Takeda Satoru , Arai Hajime , Itakura Atsuo , Makino Shintaro
Published: January 2025

Group B streptococcus (GBS) is a major global cause of neonatal, infant, and maternal infections. In Japan, national guidelines based on Centers for Disease Control and Prevention recommendations mandate culture-based screening and intrapartum antibiotic prophylaxis (IAP) for GBS-positive pregnant women. Despite initial reductions in GBS infections, the incidence has plateaued, and there are notable limitations in current prevention methods. Approximately 15% of pregnant women are not screened for GBS, and intermittent colonization undermines screening accuracy, contributing to early-onset disease. IAP does not prevent late-onset disease, the incidence of which is increasing in Japan. This study reviewed maternal and neonatal GBS colonization using polymerase chain reaction, evaluated capsular type distributions, and explored late-onset disease infection routes. Among 525 mother-neonate pairs, the study found a higher detection rate of GBS via polymerase chain reaction compared to culture methods and identified significant discrepancies between antepartum and intrapartum colonization. GBS was detected in 3.5% of neonates from initially negative mothers at 4 days of age. Capsular types varied between mothers and neonates, indicating potential horizontal transmission. This study underscores the need for improved rapid diagnostic tests and highlights the potential of maternal GBS vaccination as a future prevention strategy.
Case-only analysis of routine surveillance data: detection of increased vaccine breakthrough infections with SARS-CoV-2 variants in Europe
Authors: Brown Jeremy , Mook Piers , Vanhaverbeke Maarten , Gimma Amy , Hagan José , Singini Isaac , Avdičová Mária , Cullen Gillian , Dotsenko Liidia , Mossong Joël , Sadkowska-Todys Malgorzata , Suija Heelene , Bundle Nick , Pebody Richard
Published: January 2025

With the ongoing emergence of SARS-CoV-2 variants, there is a need for standard approaches to characterize the risk of vaccine breakthrough. We aimed to estimate the association between variant and vaccination status in case-only surveillance data. Included cases were symptomatic adult laboratory-confirmed COVID-19 cases, with onset between January 2021 and April 2022, reported by five European countries (Estonia, Ireland, Luxembourg, Poland, and Slovakia) to The European Surveillance System. Associations between variant and vaccination status were estimated using conditional logistic regression, within strata of country and calendar date, and adjusting for age and sex. We included 80,143 cases including 20,244 Alpha (B.1.1.7), 152 Beta (B.1.351), 39,900 Delta (B.1.617.2), 361 Gamma (P.1), 10,014 Omicron BA.1, and 9,472 Omicron BA.2. Partially vaccinated cases were more likely than unvaccinated cases to be Beta than Alpha (adjusted odds ratio [aOR] 2.48, 95% CI 1.29–4.74), and Delta than Alpha (aOR 1.75, 1.31–2.34). Fully vaccinated cases were relative to unvaccinated cases more frequently Beta than Alpha (aOR 4.61, 1.89–11.21), Delta than Alpha (aOR 2.30, 1.55–3.39), and Omicron BA.1 than Delta (aOR 1.91, 1.60–2.28). We found signals of increased breakthrough infections for Delta and Beta relative to Alpha, and Omicron BA.1 relative to Delta.
IL-17 affects the immune regulation of CD4+ T cells in dilated cardiomyopathy through JAK/STAT pathway
Authors: Hao Jie , Li Weiwei , Jiao Wei , Li Fang , Xie Yanan
Published: January 2025

Purpose:

Studying the effect of interleukin-17 (IL-17) on the mechanism of CD4+ T-cell immune regulation and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway may offer new ideas and methods for the therapy of dilated cardiomyopathy.

Methods:

Naive CD4+ T cells were isolated from mice using a magnetic bead sorting reagent and manipulated by overexpression or knockdown of IL-17. Protein levels of Janus kinase 2 (JAK2), phosphorylated JAK2 (p-JAK2), signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) were determined by Western blotting. Quantitative polymerase chain reaction was used to assess the levels of JAK2, STAT3, MMP-2, and MMP-9. Expression of tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-4 (IL-4), and interferon-gamma (IFNγ) was determined by enzyme-linked immunosorbent assay test kits. TNF-α, IL-1β, IL-4, and IFNγ secretion was measured by flow cytometry.

Results:

In CD4+ T cells, IL-17 overexpression increased TNF-α, IL-1β, IL-4, IFNγ, p-JAK2, p-STAT3, MMP-2, MMP-9 levels, and apoptosis. Knockdown of IL-17 reduced the levels of TNF-α, IL-1β, IL-4, IFNγ, p-JAK2, p-STAT3, MMP-2, and MMP-9, as well as the level of apoptosis.

Conclusion:

Through regulation of IL-17 expression in CD4+ T cells, this study reveals its crucial role in regulating the secretion of inflammatory factors, activation of the JAK/STAT signaling pathway, expression of matrix metalloproteinases, and apoptosis of CD4+ T cells.
Catastrophic antiphospholipid antibody syndrome associated with ischaemic cardiomyopathy
Authors: Pacella Jonathan , Rodriguez-Smith Jackeline , Kessler Haeja , Mantell Benjamin S.
Published: January 2025

We report the case of a 16-year-old female with previously diagnosed bilateral sub-segmental pulmonary emboli who presented in cardiogenic shock from depressed biventricular function with cardiac MRI demonstrating concern for microvascular coronary injury. She was ultimately diagnosed with catastrophic antiphospholipid antibody syndrome-induced ischaemic cardiomyopathy, potentially associated with an underlying autoimmune connective tissue disease.
Association of antidepressants with cataracts and glaucoma: a disproportionality analysis using the reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS) pharmacovigilance database
Authors: Le Gia Han , Wong Sabrina , Kwan Angela T.H. , Rosenblat Joshua D. , Mansur Rodrigo B. , Teopiz Kayla M. , Ho Roger , Rhee Taeho Greg , Vinberg Maj , Cao Bing , Liao Sonya , McIntyre Roger S.
Published: January 2025

Background

Antidepressants are commonly prescribed for mood disorders. Epidemiological studies suggest antidepressant use may be associated with cataracts and glaucoma. We aim to investigate the association between antidepressants and cataracts and glaucoma.

Methods

Data was collected from the United States Food and Drug Administration Adverse Event Reporting System. Reporting odds ratio (ROR) and Bayesian information components (IC025) were calculated for antidepressants (ie, selective serotonin reuptake inhibitors [SSRIs], selective norepinephrine reuptake inhibitors [SNRIs], serotonin-norepinephrine-dopamine reuptake inhibitors, serotonin modulators and stimulators, serotonin antagonists and reuptake inhibitors [SARIs], norepinephrine reuptake inhibitors, norepinephrine-dopamine reuptake inhibitors, tricyclic antidepressants [TCAs], tetracyclic antidepressants [TeCAs], and monoamine oxidase inhibitors [MAOIs]). The reference agent was acetaminophen.

Results

TeCAs and MAOIs were significantly associated with a decreased risk of cataracts (ROR = 0.11-0.65 and 0.16-0.69, respectively). TCAs, brexanolone, esketamine, and opipramol reported an increased cataract risk (ROR = 1.31-12.81). For glaucoma, SSRIs, SNRIs, SARIs, TCAs, MAOIs, and other investigated antidepressants reported significant RORs ranging from 1.034 to 21.17. There was a nonsignificant association of angle closure glaucoma (ACG) and open angle glaucoma (OAG) with the investigated antidepressants.

Limitations

For adverse event cases, multiple suspected product names are listed, and as cases are not routinely verified, there may be a possibility of duplicate reports and causality cannot be established.

Conclusion

Most of the investigated antidepressants were associated with a lower risk of cataract reporting. TCAs, brexanolone, esketamine, and opipramol were associated with greater odds of cataract. For most antidepressants, there was an insignificant increase in reports of ACG and OAG.
Radial and Latitudinal Distributions of the Exohiss Under the Effect of Landau Damping
Authors: Ding Xiangling , He Zhaoguo , Wu Zhiyong , Yu Jiang , Li Kun , Ye Yuguang , Zong Qiugang
Published: January 2025

Exohiss serves as a typical imprint of the outward energy release from plasmaspheric hiss. The distribution of exohiss under the effect of Landau damping has not been thoroughly evaluate. On the basis of observations from the Van Allen Probes on 17 February 2014, we performed two‐dimensional ray tracing simulations to model the evolution of hiss waves propagating from the geomagnetic equator in plasmasphere. The results show that the hiss wave power decreases rapidly as the waves enter the plasmatrough under the enhanced Landau damping effect of hot electrons. Furthermore, we perform a statistical analysis of the simulation results from multiple rays and obtain the radial, latitudinal, and frequency distributions of the exohiss wave power. The modeled distribution characteristics of exohiss align well with observations, suggesting that Landau damping is crucial in shaping the morphology of exohiss in the inner magnetosphere.
Ionospheric Conductances at the Giant Planets of the Solar System: A Comparative Study of Ionization Sources and the Impact of Meteoric Ions
Authors: Clément Noé , Nakamura Yuki , Blanc Michel , Wang Yuxian , Al Saati Sariah
Published: January 2025

The dynamics of giant planet magnetospheres is controlled by a complex interplay between their fast rotation, their interaction with the solar wind, and their diverse internal plasma and momentum sources. In the ionosphere, the Hall and Pedersen conductances are two key parameters that regulate the intensity of currents coupling the magnetosphere and the ionosphere, and the rate of angular momentum transfer and power carried by these currents. We perform a comparative study of Hall and Pedersen conductivities and conductances in the four giant planets of our Solar System ‐ Jupiter, Saturn, Uranus and Neptune. We use a generic ionospheric model (restraining the studied ions to , , and meteoric ions) to study the dependence of conductances on the structure and composition of these planets' upper atmospheres and on the main ionization sources (photoionization, ionization by precipitating electrons, and meteoroid ablation). After checking that our model reproduces the conclusions of Nakamura et al. (2022), https://doi.org/10.1029/2022ja030312 at Jupiter, that is, the contribution of meteoric ions to the height‐integrated conductances is non‐negligible, we show that this contribution could also be non‐negligible at Saturn, Uranus and Neptune, compared with ionization processes caused by precipitating electrons of energies lower than a few keV (typical energies on these planets). However, because of their weaker magnetic field, the conductive layer of these planets is higher than the layer where meteoric ions are mainly produced, limiting their role in magnetosphere‐ionosphere coupling.
Microseism Amplitude and Wave Power in the Mediterranean Sea (1996–2023)
Authors: Borzì Alfio Marco , Cannata Andrea , Panzera Francesco , D’Amico Sebastiano , Lo Re Carlo , Aster Richard C.
Published: January 2025

In this work, we integrate seismic data recorded by nine coastal Mediterranean seismic stations and wave hindcast data for 1 January 1996 through 15 October 2023. We examine the relationships between the ocean wave‐generated microseism signal (the most continuous and ubiquitous seismic signal on Earth) in terms of temporally varying spectral content, root mean square amplitude, and microseism power spectral density, with the main features of principal ocean wave attributes, specifically significant wave heights, wave period and wave power. To explore relationships between microseism and sea state, we performed a correlation analysis between seismic root square mean amplitude and significant wave height time series for the entire Mediterranean Sea for 1996–2023, including retrieving long‐term trends for microseism energy and independently estimated wave power and calculating the Spearman correlation coefficient between the two trend time series. Despite the small number of stations available the analysis allows for a useful exploratory study on the microseism and its relationship with Mediterranean Sea state and wave power spanning 27 years. Given the recent increase in the number of regional seismic stations, the growth of data sharing, and the intensification of global warming and climate extreme events, the results and methods explored here can be further implemented and developed in coming years for coastal monitoring purposes in complement with other data sources.
Intraseasonal Variations in the Indian Ocean Cross‐Equatorial Cell During the Subsequent Boreal Summer of ENSO
Authors: Liu Yu , Xu Kang , Wang Weiqiang , Chen Sheng , He Zhuoqi , Xie Qiang , Arulananthan K. , Kumara P. B. Terney Pradeep
Published: January 2025

The interannual relationships between the cross‐equatorial cell (CEC) in the Indian Ocean (IO) and the El Niño‐Southern Oscillation (ENSO) are examined through observational data and numerical simulations. The findings indicate a notable intraseasonal variation in the boreal summer IO CEC responses to preceding ENSO events, showing a weakening in early summer (May–June) and a strengthening in late summer (August–September) subsequent to an El Niño events. These contrasting responses are primarily driven by opposite meridional Ekman transport anomalies, characterized by anomalous northward Ekman transport in early summer and southward transport in late summer. Further analysis reveals that ENSO‐induced surface zonal wind anomalies predominantly influence these anomalous meridional Ekman transport in the upper layer, accounting for over 80% of the variation. In early summer, an antisymmetric wind pattern over the IO, induced by El Niño in the decaying spring, along with the westward extension of the anomalous western North Pacific anticyclone (WNPAC), generates anomalous easterlies over the North IO (NIO), leading to weakened meridional Ekman transport and a diminished CEC. Simultaneously, those anomalous easterlies and the associated weakened CEC in early summer trigger a wind‐CEC‐SST (WCS) negative feedback mechanism. The resulting anomalous northward transport and reduced upwelling lead to sea surface temperature (SST) warming in the northern NIO, creating a northward surface ocean temperature gradient in the July–August period. This gradient, along with the eastward retreat of the WNPAC, causes anomalous NIO westerlies in late summer, enhancing meridional Ekman transport and ultimately strengthening the CEC.
An Analytical Framework for Risk Evaluation and Design of Infiltration Basins for Managed Aquifer Recharge
Authors: Fiori Aldo , de Barros Felipe P. J. , Bellin Alberto
Published: January 2025

Managed Aquifer Recharge (MAR) plays an important role in improving and supplementing groundwater storage. Many natural factors, ranging from climatic conditions to soil characteristics, can impact the efficiency of an infiltration basin. Other factors, such as engineered variables, will also influence the basin performance and the risks associated with groundwater contamination. The latter depends on the interplay between the hydraulic characteristics of the system and the soil and solute properties. The design of infiltration basins has been performed so far with the main objective of mitigating the tendency of the basin to reduce the infiltration rate with time due to clogging of the basin's bottom. Less attention has been paid to the risk of groundwater contamination by the infiltrating water. To understand the complex interplay between natural and engineering parameters on MAR efficiency and the contamination risk, we propose a risk‐oriented analytical framework. The framework allows to investigate the interplay between soil parameters, engineering design and climatic factors on the efficiency of an infiltration basin. Our framework relies on novel analytical solutions that relates the geometrical and hydrological features of the infiltration basin to its efficiency and groundwater contamination risk. The solutions incorporates the randomness associated with inflows (precipitation) and soil properties. We explore the trade‐off between efficiency and the risk of contamination and delineate a design procedure that balances these two opposing needs. Although the framework relies on simplifying assumptions, it provides a computationally efficient manner to obtain physical insights and relate model input parameters to decision making.
Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis
Authors: Wang Fei , Deng Haiyi , Zhou Maolin , Yang Yilin , Zhou Jiankui , Wang Yansheng , Xie Xiaohong , Lin Xinqing , Liu Ming , Sun Gengyun , Zhou Chengzhi
Published: January 2025

Immune checkpoint inhibitors (ICIs) have significant therapeutic effects but can also cause fatal lung injury. However, the lack of mouse animal models of ICI-related lung injury (ICI-LI) has limited the in-depth exploration of its pathogenesis. In clinical practice, underlying lung diseases increase the risk of lung injury. Thus, we used a mouse model of lung injury induced by bleomycin (BLM) and then administered anti-programmed cell death 1 (aPD-1) antibodies to induce ICI-LI. Compared with the BLM group, the aPD-1 + BLM group presented more significant weight loss, greater levels of lung inflammation and fibrosis, and decreased lung function. In this ICI-LI model, high levels of caspase-3/gasdermin E (GSDME) were detected in the lung tissue of mice, and the JNK inhibitor SP600125 mitigated lung damage by inhibiting GSDME-mediated pyroptosis. Consistent with the findings in the animal model, immunofluorescence and RNA sequencing of lung tissue from ICI-LI patients revealed upregulation of the expression of genes related to the GSDME-related pyroptosis pathway. Our results suggest that GSDME-mediated pyroptosis may be associated with the pathogenesis of ICI-LI, indicating that targeting GSDME could be a potential therapeutic strategy for treating ICI-LI.
Multi-channel learning for integrating structural hierarchies into context-dependent molecular representation
Authors: Wan Yue , Wu Jialu , Hou Tingjun , Hsieh Chang-Yu , Jia Xiaowei
Published: January 2025

Reliable molecular property prediction is essential for various scientific endeavors and industrial applications, such as drug discovery. However, the data scarcity, combined with the highly non-linear causal relationships between physicochemical and biological properties and conventional molecular featurization schemes, complicates the development of robust molecular machine learning models. Self-supervised learning (SSL) has emerged as a popular solution, utilizing large-scale, unannotated molecular data to learn a foundational representation of chemical space that might be advantageous for downstream tasks. Yet, existing molecular SSL methods largely overlook chemical knowledge, including molecular structure similarity, scaffold composition, and the context-dependent aspects of molecular properties when operating over the chemical space. They also struggle to learn the subtle variations in structure-activity relationship. This paper introduces a multi-channel pre-training framework that learns robust and generalizable chemical knowledge. It leverages the structural hierarchy within the molecule, embeds them through distinct pre-training tasks across channels, and aggregates channel information in a task-specific manner during fine-tuning. Our approach demonstrates competitive performance across various molecular property benchmarks and offers strong advantages in particularly challenging yet ubiquitous scenarios like activity cliffs.
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
Authors: Fackelmann Gloria , Manghi Paolo , Carlino Niccolò , Heidrich Vitor , Piccinno Gianmarco , Ricci Liviana , Piperni Elisa , Arrè Alberto , Bakker Elco , Creedon Alice C. , Francis Lucy , Capdevila Pujol Joan , Davies Richard , Wolf Jonathan , Bermingham Kate M. , Berry Sarah E. , Spector Tim D. , Asnicar Francesco , Segata Nicola
Published: January 2025

As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little is known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences in diet pattern (omnivore, vegetarian and vegan) are reflected in gut microbiomes. Microbial profiles distinguished these common diet patterns well (mean AUC = 0.85). Red meat was a strong driver of omnivore microbiomes, with corresponding signature microbes (for example, Ruminococcus torques, Bilophila wadsworthia and Alistipes putredinis) negatively correlated with host cardiometabolic health. Conversely, vegan signature microbes were correlated with favourable cardiometabolic markers and were enriched in omnivores consuming more plant-based foods. Diet-specific gut microbes partially overlapped with food microbiomes, especially with dairy microbes, for example, Streptococcus thermophilus, and typical soil microbes in vegans. The signatures of common western diet patterns can support future nutritional interventions and epidemiology.
Engineering covalent small molecule–RNA complexes in living cells
Authors: Bereiter Raphael , Flemmich Laurin , Nykiel Kamila , Heel Sarah , Geley Stephan , Hanisch Malou , Eichler Clemens , Breuker Kathrin , Lusser Alexandra , Micura Ronald
Published: January 2025

Covalent labeling of RNA in living cells poses many challenges. Here we describe a structure-guided approach to engineer covalent RNA aptamer–ligand complexes. The key is to modify the cognate ligand with an electrophilic handle that allows it to react with a guanine at the RNA binding site. We illustrate this for the preQ1-I riboswitch, in vitro and in vivo. Further, we demonstrate the versatility of the approach with a covalent fluorescent light-up aptamer. The coPepper system maintains strong fluorescence in live-cell imaging even after washing, can be used for super-resolution microscopy and, most notably, is uniquely suited for fluorescence recovery after photobleaching to monitor intracellular RNA dynamics. In addition, we have generated a Pepper ligand with a second handle for bioorthogonal chemistry to allow easily traceable pull-down of the covalently linked target RNA. Finally, we provide evidence for the suitability of this tethering strategy for drug targeting.
Context-dependent decision-making in the primate hippocampal–prefrontal circuit
Authors: Elston Thomas W. , Wallis Joni D.
Published: January 2025

What is good in one scenario may be bad in another. Despite the ubiquity of such contextual reasoning in everyday choice, how the brain flexibly uses different valuation schemes across contexts remains unknown. We addressed this question by monitoring neural activity from the hippocampus (HPC) and orbitofrontal cortex (OFC) of two monkeys performing a state-dependent choice task. We found that HPC neurons encoded state information as it became available and then, at the time of choice, relayed this information to the OFC via theta synchronization. During choice, the OFC represented value in a state-dependent manner; many OFC neurons uniquely coded for value in only one state but not the other. This suggests a functional dissociation whereby the HPC encodes contextual information that is broadcast to the OFC via theta synchronization to select a state-appropriate value subcircuit, thereby allowing for contextual reasoning in value-based choice.
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus
Authors: Wu Yicheng , Korobeynyk Vladyslav I. , Zamboni Margherita , Waern Felix , Cole John Darby , Mundt Sarah , Greter Melanie , Frisén Jonas , Llorens-Bobadilla Enric , Jessberger Sebastian
Published: January 2025

The mammalian dentate gyrus (DG) is involved in certain forms of learning and memory, and DG dysfunction has been implicated in age-related diseases. Although neurogenic potential is maintained throughout life in the DG as neural stem cells (NSCs) continue to generate new neurons, neurogenesis decreases with advancing age, with implications for age-related cognitive decline and disease. In this study, we used single-cell RNA sequencing to characterize transcriptomic signatures of neurogenic cells and their surrounding DG niche, identifying molecular changes associated with neurogenic aging from the activation of quiescent NSCs to the maturation of fate-committed progeny. By integrating spatial transcriptomics data, we identified the regional invasion of inflammatory cells into the hippocampus with age and show here that early-onset neuroinflammation decreases neurogenic activity. Our data reveal the lifelong molecular dynamics of NSCs and their surrounding neurogenic DG niche with age and provide a powerful resource to understand age-related molecular alterations in the aging hippocampus.
Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl
Authors: Earl Christopher P. , Cobbaut Mathias , Barros-Carvalho André , Ivanova Marina E. , Briggs David C. , Morais-de-Sá Eurico , Parker Peter J. , McDonald Neil Q.
Published: January 2025

The mutually antagonistic relationship of atypical protein kinase C (aPKC) and partitioning-defective protein 6 (Par6) with the substrate lethal (2) giant larvae (Lgl) is essential for regulating polarity across many cell types. Although aPKC–Par6 phosphorylates Lgl at three serine sites to exclude it from the apical domain, aPKC–Par6 and Lgl paradoxically form a stable kinase–substrate complex, with conflicting roles proposed for Par6. We report the structure of human aPKCι–Par6α bound to full-length Llgl1, captured through an aPKCι docking site and a Par6PDZ contact. This complex traps a phospho-S663 Llgl1 intermediate bridging between aPKC and Par6, impeding phosphorylation progression. Thus, aPKCι is effectively inhibited by Llgl1pS663 while Llgl1 is captured by aPKCι–Par6. Mutational disruption of the Lgl–aPKC interaction impedes complex assembly and Lgl phosphorylation, whereas disrupting the Lgl–Par6PDZ contact promotes complex dissociation and Lgl phosphorylation. We demonstrate a Par6PDZ-regulated substrate capture-and-release model requiring binding by active Cdc42 and the apical partner Crumbs to drive complex disassembly. Our results suggest a mechanism for mutual regulation and spatial control of aPKC–Par6 and Lgl activities.
NEBULA101: an open dataset for the study of language aptitude in behaviour, brain structure and function
Authors: Rampinini Alessandra , Balboni Irene , Kepinska Olga , Berthele Raphael , Golestani Narly
Published: January 2025

This paper introduces the “NEBULA101 - Neuro-behavioural Understanding of Language Aptitude” dataset, which comprises behavioural and brain imaging data from 101 healthy adults to examine individual differences in language and cognition. Human language, a multifaceted behaviour, varies significantly among individuals, at different processing levels. Recent advances in cognitive science have embraced an integrated approach, combining behavioural and brain studies to explore these differences comprehensively. The NEBULA101 dataset offers brain structural, diffusion-weighted, task-based and resting-state MRI data, alongside extensive linguistic and non-linguistic behavioural measures to explore the complex interaction of language and cognition in a highly multilingual sample. By sharing this multimodal dataset, we hope to promote research on the neuroscience of language, cognition and multilingualism, enabling the field to deepen its understanding of the multivariate panorama of individual differences and ultimately contributing to open science.
Electro-polymerization of modified carbon paste sensor for detecting azithromycin
Authors: Mamdouh Salma , Shehata M. , Fekry A. M. , Ameer M. A.
Published: January 2025

Azithromycin (AM) is one of the prescribed drugs in pandemic medication treatment which has paid great attention. We developed in this study a simply modified carbon paste electrode (CPE) to detect AM using poly-threonine (PT). PT or similar polymers are used as carriers to enhance the delivery and effectiveness of AM. The work was characterised via Cyclic Voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). We take into consideration the effects of pH, scan rate, accumulation time, interference, and calibration curve.A very sensitive response to the oxidation of 1.0 mM from AM in phosphate buffer solution (PBS) over a pH range of 5.0 to 10.0 was observed using the developed poly-threonine carbon paste electrode (PTCPE). The impact of different AM concentrations was investigated resulting in a detection limit of 0.32 µM and a quantification limit of 1.07 µM at PBS (pH 7.4). Finally, the recently used electrode realized acceptable sensitivity and consistency for AM detection in pharmaceutical drugs.