bluuebunny/crossref_metadata_2025 huggingface dataset:
RESEARCH OF EMOTIONAL INTELLIGENCE OF CHESS TEACHERS AND PUPILS
Authors: Sargsyan Anzhela , Khachatryan Armine
Published: April 2023

The research relevance is conditioned by the lack of experimental data on the study of the level of emotional intelligence of teachers and learners of the "Chess" subject.The aim of the research is to identify the level of emotional intelligence of teachers and junior schoolchildren and their manifestation during the teaching and mastering of the “Chess” subjects. In accordance with the purpose of the research, "Happy and sad", "Do you understand emotions by mimics?", "Emotions identification, pupil", " Emotions identification, teacher", N. Holly's intellectual level diagnostic methodologies have been applied. The study results. Summarizing the results of analyses of all the applied methods during this research, it can be concluded that the low indicators of empathy of the teachers, managing emotions of themselves and others affects both the motivation to success of the 3rd and 4th grade pupils as well as the negative attitude to obtaining the teacher's appraisal, as a result of which the indicator of a positive attitude towards the teacher of the chess is diminished. The practical significance of the research. Taking into account the data analysis of the results of this study, we suggest providing training program in the chess teachers. The aim is to increase the level of development of chess teachers' emotional intelligence, to develop the ability of schoolchildren to recognize, distinguish and title the emotions of chess classes.The goal is to increase the level of development of chess teachers' emotional intelligence, to develop the ability to recognize, distinguish and title the emotions of schoolchildren in chess classes.
Revision of the Hungarian Euchromius Guenée, 1845 species (Lepidoptera: Crambidae)
Authors: Fazekas Imre
Published: April 2023

Hungarian Euchromius are revised and list of localities is provided. Structure of genitalia and morphological characteristics of wings are illustrated by figures. The habitats and Hungarian distribution of the species have been analysed, the latter shown on UTM-grid maps. The study is completed with references on the Hungarian distribution of the species. With 8 figures.
Waterfowl population survey of the Marcali reservoir (2007–2008)
Authors: Kovács Gyula , Nagy Ádám , Winkler Dániel
Published: April 2023

This study has shown that the Marcali reservoir is an important waterbird wetland habitat especially during the migration period. Based on our findings early springtime season proved to be the most important season concerning bird activities on the reservoir. The reservoir and its surroundings are not specifically important as breeding areas; although, some strictly protected species can be found among the breeding species. It is noteworthy to mention the strong disturbance (waterfolw hunting, intensive fishing, poaching) in the area that can have a negative impact on the breeding success of bird species. The results of similarity measures showed remarkable differences between the bird communities of different seasons. Waterbird communities of the spring season and summer season showed the highest similarity, since part of the species observed during the spring surveys were most probably breeding species that remained in the reservoir area for the summer. Comparison based on bird species diversity showed significant differences between communities of the different seasons. Diversity was higher both in the breeding and the migration season compared with the winter period characterized by the lowest species richness and number of individuals. Water level has proved to be an important determining factor of waterbird species richness.
A Mecsek és környéke fürkészlégy faunája (Diptera: Tachinidae)
Authors: Tóth Sándor
Published: April 2023

A szerző jelen tanulmányban közli a Mecsekben és környékén általa gyűjtött fürkészlégy-fajok lelőhelyadatait. Elterjedésre, gyakoriságra és életmódbeli sajátosságokra is vonatkozó jellemzést is ad a fajokról, összesen 103 ábrával.
Effects of Butylated HydroxylToluene and Vitamin E on Cadmium-Lead toxicity on the liver of rats
Authors: Kadiri Helen E. , Idholo Blessing
Published: April 2023

This study determined the effect of lead-cadmium toxicity in the liver of albino rats. 56 rats were divided into 7 groups of 8 rats each and were treated as follows : Group A Control (1 ml of diluent (corn oil); Group B (15mg/kg BW cadmium); Group C(50mg/kg BW lead); Group D (15mg/kg BW Cadmium and 50mg/kg BW lead); Group E (15mg/kg BW cadmium, 50mg/kg BW lead and 23mg/kg BW vitamin E);Group F (15mg/kg BW cadmium, 50mg/kg BW lead and 25mg/kg BW Butylated HydroxylToluene) and Group G (15 mg/kg BW Cd+50mg/kg BW lead+25mg/kg BW (BHT + vitamin E). Rats were sacrificed on the 29th and 56th day in sub-acute and chronic exposure respectively. Liver function, oxidative stress markers and histological examination were carried out. Results indicate that rats exposed to cadmium and lead suffered liver damage due to the significant (P<0.05) increase in Alanine Transferase, Aspartate transferase and Alkaline phosphatase, and significant decrease (P<0.05) in Total Protein and Albumin in the serum. Malonaldehyde (MDA) levels were also significantly increased (P<0.05) with a concomitant decrease in Superoxide dismutase, catalase and Glutathione peroxidase activities in both the chronic and acute exposure phase. Vitamin E and BHT singly had little ameliorative effect on the liver; however, a combination of these antioxidants reduced the enzymes levels significantly. Treatment with the antioxidants (Vitimin E and BHT) both singly and combined was also able to ameliorate the effects of the oxidative stress induced by the metals as was further confirmed by the histopathological reports.
Gender Audit as Basis in Developing Modules for GAD Focal Persons in Mati, Davao Oriental, Philippines
Authors: Villegas Jhonnel P. , Bauyot Mary Fil M. , Sacro Jeralyn H. , Siarot Leorisyl D.
Published: April 2023

Many countries across the globe, including the Philippines, have implemented Gender and Development (GAD) policies to reduce gender biases and promote equality. However, mainstreaming efforts have been challenging due to the scarce availability of learning resources in the local context. This study is an initiative to provide the GAD Focal Point System (GFPS) in the Department of Education – City of Mati with a primary reference in training their GAD Focal Persons on Gender Sensitivity, GAD Planning, and Budgeting (GPB). The coverage is based on their learning needs and gaps determined through participatory strategies involving the school administrators, teachers, students, and parents. Also, the results of the gender audit using the Gender Mainstreaming Evaluation Framework (GMEF) are used as a baseline in module development. The framework presents strategic directions that agencies need to follow to advance across stages. It was found that Mati’s primary and secondary schools are in the initial stages of gender mainstreaming. As such, GAD’s basic concepts and definitions are introduced, along with various forms of gender-based violence and the appropriate mechanisms to address them aptly. The essential steps in planning and budgeting are also detailed, providing an active experience among the participants. It is imperative to sustain GAD capacity-building initiatives to catalyze a more directed and engaged policy framework.
Training of the Forces for Carrying Out Military Actions in Operational Environments Characterized by the Existence of Hybrid Threats
Authors: Cîrdei Ionuţ Alin
Published: April 2023

In the current operational context, the armed forces will be put in a position to carry out military actions in complex, unpredictable and volatile environments, characterized by uncertainty and a high degree of risk. They will face multidimensional threats and will need to demonstrate adaptability and flexibility to meet all challenges. In order to be able to carry out their missions in the context of the existence of more and more hybrid threats, the armed forces must go through a training process that allows them to know the confrontational environment, identify the threats, understand them and use the better ways to counter them, while maintaining operational capability. Armed forces training must be as realistic as possible, based on a comprehensive approach to training and to aim to expose warfighters and decision makers to operational conditions as close as possible to those of the hybrid battlefield.
Esther Rando Burgos: Régimen Jurídico de la Gestión Territorial
Authors: Farinós Dasí Joaquín
Published: April 2023

Recensión del libro de Esther Rando Burgos, Régimen jurídico de la Gestión Territorial. Tirant lo Blanch, 2020, 464 pp. Prólogo de Diego J. Vera Jurado. La obra analiza de forma novedosa, rigurosa y completa, cómo gestionar la ordenación del territorio, uno de los grandes retos de la ordenación del territorio en nuestro país. Y lo hace aportando soluciones y herramientas que, desde el punto de vista jurídico, pueden ser determinantes en el avance de esta polémica cuestión. La autora presenta de manera rigurosa el inexistente régimen jurídico existente y, en lo que constituye todo un referente en esta función pública, lo configura, dotándolo incluso de los mecanismos jurídicos que pueden posibilitar su puesta en marcha.
FALÁCIA DEMOCRÁTICA: UMA REFLEXÃO SOBRE O PARADIGMA ESTRUTURAL BRASILEIRO
Authors: Dos Santos José Ricardo Rosa , Da Silva Juliana Oliveira
Published: April 2023

Este ensaio tem como objetivo demonstrar que a cultura dominante reforçada por meio das estruturas simbólicas reproduz na sociedade uma realidade desigual, tornando contraditória e ambígua a própria noção de democracia. Trata-se de uma revisão de literatura, utilizando pesquisa bibliográfica e eletrônica. Tomou-se como base teórica autores como Santos (2007), Freire (2002), Nidelcoff (1999) e Habermas (1997). A pesquisa mostrou que é necessário um trabalho de conscientização sobre a importância da participação democrática direta, pregada por Harbemas, através de uma educação dialética cujo objetivo seja a justiça social.
ESTADO BRASILEIRO: UM PAÍS DE MODELO ECONÔMICO ATUAL KEYNESIANO OU NEOLIBERAL?
Authors: De Carvalho Francisca Andreza Alves , Rossignoli Marisa
Published: April 2023

Situar o Brasil economicamente como um país que se identifica com uma ideologia Neoliberal ou Keynesiana, é uma tarefa que só é possível a partir de uma análise do processo de formação histórica e cultural do País, por meio do qual se identifica que o cidadão sempre assumiu, na história brasileira, uma posição de sujeito passivo e não ativo, quando se fala de participação nas decisões políticas e decisivas para constituição do país. Nessa perspectiva, o presente trabalho, busca demonstrar, partindo-se de uma análise do Neoliberalismo e Keynesianismo na Europa e no Brasil, como tais correntes se apresentaram na realidade brasileira, em vários momentos, alternadamente, buscando situar economicamente, nessas duas vertentes de doutrinas econômicas, o Brasil que se apresenta nos dias atuais. O método utilizado foi o dedutivo, com uso de revisão bibliográfica. Como resultado verifica-se que partindo-se de uma análise histórica e Constitucional da realidade brasileira, pode se identificar elementos de ordem Neoliberal, bem como de vertente Keynesiana, os quais regulam a atuação estatal na ordem Constitucional dos dias atuais.
Seed Oil Extraction of Cucurbita maxima Duchesne Growing in Madagascar: Impact of Storage and Use of a Cineole–Rich Essential Oil as a Green Solvent
Authors: Rakotondrazafy Nirina , Farasoa Helga Rim , Ramanandraibe Voahangy Vestalys
Published: April 2023

The performance of a cineole-rich essential oil as an extraction solvent for vegetable oil was studied. This essential oil was obtained from Melaleuca quinquenervia (Cav.) St Blake Myrtaceae, commonly called niaouli, an invasive plant on the eastern coast of Madagascar. The whole essential oil was used without preliminary isolation of terpenes. Experimentation was carried out with Cucurbita maxima Duchesne Cucurbitaceae seeds. The Soxhlet method was used for the oil extraction, and solvent recovery was performed by hydrodistillation. Niaouli essential oil allowed a better extraction yield of 39% compared to hexane, with 36%. The linoleic acid content of the oil was also higher: 37.19% against 7.25% for hexane. After 30 weeks of storage, the seed powder linoleic acid content increased to 44.99% for niaouli oil against 25.00% for hexane oil. With the screw press extraction method, the best yield of 13.00% was obtained with roasting pretreatment while heating at 60°C. However, the best oleic acid content of 45.36% was obtained at 50°C. It was demonstrated that the seed powder underwent biochemical changes during storage which were similar to intracellular catabolic reactions of fatty acids. The high expenses induced by the deterpenation process in terms of cost and energy limit the diffusion and the development of the use of terpenes as alternative solvents. The results of this research support the idea that it is possible to avoid this costly step by directly using the entire essential oil since this can provide a vegetable oil of good quality.
Room Temperature Surface Bio-Sulfurisation via Natural

Sativum Annilin and Bioengineering of Nanostructured CuS/Cu

2S
Authors: Welegergs Giday Gebregziabher , Numan N , Dube S , Nuru Z , Botha N , Cloete K , Azizi Sh , Madiba I , Akbari M , Tsegay M , Gebretinsae H , Mtshali Ch , Khumalo Z , Ezema F , Krief A. , Gibaud A , Henini M , Seopela M.P , Chaker M , Maaza M
Published: April 2023

In this contribution, we report, for the first time, on the surface bio-sulfurisation of metallic surfaces at room temperature via natural
sativum annilin. More precisely, this bio-sulfurisation is validated on bioengineered nanostructured Cu
2-XS surfaces using natural organosulfur compounds emitted from
Sativum allium L. as efficient sulfurisation chemical agents. It is validated that virgin copper surfaces can be sulfurised at room temperature without adding any extra chemical or physical processes. In addition to the validation of the green sulfurisation process of the copper surface, the bioengineered Cu
2-XS exhibited a multiscale 1-D tubular morphology with Cu
2-XS nanotubules and nanocones. Such a nanostructured Cu
2-XS surface exhibited an excessive optical selectivity, a superhydrophobicity response in addition to a remarkable site selective mercury adsorption.
O papel do enfermeiro na triagem do transtorno do espectro autista durante as consultas de puericultura
Authors: Medeiros Tania de Sousa Pinheiro , Silva Natalia Karina Nascimento da , Silva Tatiane Bahia do Vale , Medeiros Lauany Silva de , Nascimento Marcia Helena Machado , Pamplona Mônica Custódia do Couto Abreu
Published: April 2023

Objetivo: Analisar a atuação do enfermeiro na vigilância do desenvolvimento infantil e descrever a atuação do enfermeiro no rastreamento dos sinais precoces de autismo na puericultura. Métodos: Trata-se de revisão integrativa da literatura, a qual realizou uma busca nos bancos de dados eletrônicos: LILACS, SciELO, MEDLINE e PubMed. Como critérios de inclusão considerou-se artigos completos, gratuitos, que contemplaram os objetivos e questão de pesquisa, publicados entre 2017 e 2022, nos idiomas português, inglês e espanhol. Os critérios de exclusão foram outros tipos de textos, artigos repetidos e não completos. Resultados: Foram selecionados e analisados sete artigos que evidenciaram a imprescindibilidade do enfermeiro na triagem do transtorno do espectro autista, entretanto apontaram a necessidade de implementação de protocolos e organogramas capazes de auxiliar os profissionais durante as consultas de puericultura, além da demanda por aprimoramento dos enfermeiros que realizam as consultas. Considerações finais: Este estudo identificou as ações de enfermagem na triagem e diagnóstico precoce do transtorno do espectro autista, a fim de promover uma melhor eficácia na avaliação dos sinais precoces.
Perfil epidemiológico da mortalidade materna em Ouro Preto - MG, de 2010 a 2020
Authors: Teixeira Amanda Miranda Matos , Sirio Marilia Alfenas de Oliveira , Mendonça Raquel de Deus , Pinto Victor Diniz
Published: April 2023

Objetivo: Descrever os óbitos maternos e o perfil epidemiológico da mortalidade materna em Ouro Preto, Minas Gerais, entre 2010 e 2020. Métodos: Trata-se de um estudo retrospectivo descritivo de cunho quantitativo. A população estudada constou de mulheres que foram a óbito no período gravídico-puerperal, atendidas em Ouro Preto, MG, no período de 2010 a 2020. Utilizou-se dados secundários do Sistema de Informação do município, pelas variáveis: sociodemográficas, características obstétricas, do pré-natal e descrição do óbito. Resultados: Entre 2010 e 2020 foram registrados 63,5 óbitos femininos por causas maternas, por 100 mil nascidos vivos. A maioria dos óbitos maternos ocorreram em mulheres adultas (100%), casadas ou em união estável (50%), não brancas (66,7%) e com ensino médio incompleto (50%). No âmbito obstétrico, houve predomínio de multigestas (66,7%), que realizaram pré-natal (83,3%), com suplementação de sulfato ferroso (33,3%) e de ácido fólico (50%) e com intercorrências na gestação (50%). As principais causas dos óbitos foram: embolia pulmonar (33,3%), choque hipovolêmico (33,3%) e septicemia (33,3%). Conclusão: O perfil de mortalidade materna municipal evidencia vulnerabilidade social e causas-óbito evitáveis.
Perfil dos pacientes com Infarto Agudo do Miocárdio em um hospital da capital alagoana
Authors: Gonçalves Maysa Diniz Santos , Rodrigues Wanessa Guimarães , Carvalho Laura Angellita Silva
Published: April 2023

Objetivo: Determinar o perfil da população assistida com Infarto Agudo do Miocárdio em hospital de Maceió no período de 2017 a 2021. Métodos: Estudo transversal, descritivo e retrospectivo, realizado no serviço de Cardiologia de um hospital da capital alagoana. Coletados dados em 1046 prontuários eletrônicos de pacientes internados por infarto agudo do miocárdio - CID 10 I21, no período de janeiro de 2017 a dezembro de 2021. Incluídos maiores de 18 anos com diagnóstico de infarto agudo do miocárdio. Os dados foram catalogados no Excel®, expostos em gráficos e analisados por meio de estatística descritiva. Resultados: O perfil dos pacientes diagnosticados com isquemia miocárdica durante os cinco anos analisados foi sexo masculino, oriundos da cidade de Maceió, na faixa etária de 52 a 71 anos de idade, hipertensos, diabéticos e dislipidêmicos, apresentando predominantemente infarto do miocárdio sem supra de ST. A taxa de mortalidade encontrada foi de 9,85%. Conclusão: O estudo evidenciou a influência dos fatores de risco modificáveis na incidência de isquemia miocárdica. Assim, torna-se importante o adequado controle das doenças crônicas e melhor articulação na rede de emergência para diminuir a mortalidade por essa doença.
Clinically Approved Antibiotics from 2010 to 2022
Authors: Jung Erik , Gademann Karl
Published: April 2023

This review discusses small molecule antibiotics approved for clinical use in the time frame 2010-2022. This time span saw the approval of four synthetic antibiotics (bedaquiline, pretomanid, delafloxacin, tedizolid), nine natural product derivatives (ceftaroline fosamil, cefiderocol, plazomicin, omadacycline, eravacycline, sarecycline, lefamulin, dalbavancin, oritavancin), and one natural product (fidaxomicin).
Group II Introns: Highly Structured yet Dynamic
Authors: Ahunbay Esra , Zelger-Paulus Susann , Sigel Roland K. O.
Published: April 2023

RNA splicing, the removal of introns and ligation of exons, is a crucial process during mRNA maturation. Group II introns are large ribozymes that self-catalyze their splicing, as well as their transposition. They are living fossils of spliceosomal introns and eukaryotic retroelements. The yeast mitochondrial Sc.ai5γ is the first identified and best-studied self-splicing group II intron. A combination of biochemical, biophysical, and computational tools enables studying its catalytic properties, structure, and dynamics, while also serving to develop new therapeutic and biotechnological tools. We survey the history of group II intron studies paralleling the trends in RNA methodology with Sc.ai5γ in the spotlight.
CHARACTERISTIC FEATURES OF SPIRAEOIDEAE SUBFAMILY AND BOTANICAL DESCRIPTION OF THE SPECIES WHICH DISTRIBUTED IN AZERBAIJAN
Authors: Байрамова А.А. , Исаева Н.И. , Агаев Б.И.
Published: April 2023

Подсемейство Spiraeoideae относится к семейству Rosaceae и включает в себя простейшие виды. Его представители обоеполые, а цветки правильные. Род Spiraea L. – листопадный, реже вечнозеленый кустарник или невысокое дерево, многолетнее травянистое или полукустарничковое растение. В Азербайджане в природе используются два рода, три вида и один вид используется как декоративное растение. Благодаря коробчатому типу плодов виды Spiraeoideae сходны с лютиковыми, но по таким признакам, как слегка полое ложе, срастание листьев соцветия, круговое расположение частей цветка, отличаются от лютиковых.

Spiraeoideae subfamily belongs to the family Rosaceae and includes the simplest species. Its representatives are bisexual and the flowers are regular. The genus Spiraea L. is a deciduous, rarely evergreen shrub or low tree, perennial herb or subshrub. In Azerbaijan, two genera, three species are used naturally, and one species is used as an ornamental plant. Due to the box type of fruits, Spiraeoideae species are similar to Ranunculaceae ones, but the features such as the flower bed being slightly hollow, the inflorescence leaves joining, and the circular arrangement of flower parts differ from Ranunculaceae ones.
EXPLORATION IMPACT ASSESSMENT SOIL COVER WORKS ON THE KARPOGORSKAYA AND NORAS SQUARE OF THE MEZEN SYNECLISE ACCORDING TO THE DATA OF MONITORING STUDIES
Authors: Мискевич И.В. , Семенов Н.А.
Published: April 2023

В весенне-летний период 2007 года были выполнены мониторинговые исследования для оценки воздействия геологоразведочных (сейсморазведочных) работ на окружающую среду, в том числе, на почвенный покров, на Норасской и Карпогорской площадях на территории Мезенской синеклизы в Архангельской области. Они базировались на маршрутных исследованиях фоновых участков и контрольных участков, где осуществлялись геологоразведочные работы. Получено, что такие работы, проводимые в рамках одного сезона в северной зоне тайги, не влекут за собой сверхнормативное загрязнение почв нефтяными углеводородами (нефтепродуктами) и бенз(а)пиреном.

In the spring-summer period of 2007, monitoring studies were carried out to assess the impact of geological exploration (seismic exploration) on the environment, including on the soil cover, in the Norasskaya and Karpogorskaya areas on the territory of the Mezen syneclise in the Arkhangelsk region. They were based on route studies of background areas and control areas where exploration work was carried out. It has been found that such works, carried out within one season in the northern zone of the taiga, do not entail excessive contamination of soils with petroleum hydrocarbons (petroleum products) and benzo(a)pyrene.
GEOECOLOGICAL FOUNDATIONS OF TECHNOSPHERE SAFETY
Authors: Суздалева А.Л. , Мамина Д.Х.
Published: April 2023

В статье анализируются возможности использования результатов геоэкологических исследований для обеспечения техносферной безопасности. Выделены их основные направления.

The article analyzes the possibilities of using the results of geoecological research to ensure technosphere safety. Their main directions are highlighted.
L’essentiel pour une gestion sans stress des patients porteurs d’une polykystose hépato-rénale en dialyse péritonéale.
Authors: Toure Fatouma
Published: April 2023

Résumé
La polykystose hépatorénale autosomique dominante (PKR) est une maladie rénale chronique fréquente. La dialyse péritonéale (DP) concerne moins de 7% de ces patients. La sous-utilisation de la DP est due à la crainte d’un échec technique en raison de volumineux organes intra-péritonéaux.Pour illustrer la faisabilité de la DP chez les patients PKR malgré les organomégalies. nous rapportons le cas d’une patiente de 70 ans atteinte de polykystose hépatorénale, traitée par DP après une longue histoire de transplantation rénale et d’hémodialyse. L’évolution de la patiente en DP a été satisfaisante en termes d’adéquation et d’équilibre hydrosodé. Nous faisons ensuite une revue de la littérature sur les spécificités de la prise en charge des patients PKR en DP. La survie des patients atteints de polykystose est identique en DP et en hémodialyse. Il n’y a pas de surrisque d’échec technique ni de péritonites chez les patients polykystiques en DP. Cependant, il y a un peu plus de hernies symptomatiques chez les patients polykystiques, sans impact sur la survie technique. La mesure de la pression intra-péritonéale (PIP) est une aide à la prescription, permettant d’adapter le volume de dialysat pour les échanges. En cas de nécessité de réduction néphronique, l’embolisation artérielle rénale semble être la technique à privilégier. Elle est associée à une meilleure survie technique, à une réduction des transferts temporaires ou permanents en hémodialyse et à une réduction du temps d’hospitalisation.En conclusion, la dialyse péritonéale est une option viable pour les patients atteints de polykystose hépatorénale malgré les organomégalies. Une orientation précoce en DP pourrait préserver le capital vasculaire des patients. Les professionnels de santé doivent être informés sur la survie, l’échec technique, les péritonites, les hernies symptomatiques et l’utilisation de la presssion intrapéritonéale (PIP) pour optimiser la prise en charge des patients polykystiques en DP.
Interest of HIF stabilizers in home dialysis
Authors: Rostoker Guy
Published: April 2023

Hypoxia-inducible factor (HIF) stabilizers or dustats are orally administered small molecules with very low renal elimination (without adaptation during chronic kidney disease (CKD) analogues with antagonistic effect of 2-oxoglutarate, a naturally occurring substrate of HIF-Prolyl Hydroxylase at the origin of the inhibition of this enzyme. This results in a simulated state of hypoxia allowing the accumulation of HIF-α in the cells followed by coordinated erythropoiesis with erythropoietin synthesis, decreased hepatic hepcidin production and optimization of iron metabolism. HIF stabilizers have only been studied in non-inferiority clinical trials versus erythropoiesis stimulating agents (ESAs). The primary endpoint for the therapeutic trials of all these different molecules was the change in hemoglobin level. Dustat corrects anemia in advanced non-dialysis and dialysis CKD in a similar way to ESAs.Six HIF stabilizers molecules are in advanced development: Roxadustat, Daprodustat, Vadadustat, Enarodustat, Desidustat and Molidustat. Only Roxadustat or Evrenzo®, currently has a marketing authorization in Europe obtained in August 2021. Only two studies have been dedicated to peritoneal dialysis, one with Roxadustat, the other with Daprodustat. Home dialysis appears to be an elective indication for HIF stabilizers because of their absence of cold chain necessity and their positive impact on iron metabolism and the difficulties and imperfections of the current treatment of anemia with ESA and intravenous iron in this patient population.
The engineered hexosaminidase TtOGA-D120N is an efficient O-/N-/S-glycoligase that also catalyzes formation and release of oxazoline donors for cascade syntheses with glycosynthases or transglycosylases
Authors: Beenfeldt Petersen Agnes , Hossein Mirbarati Seyed , Svensson Birte , Duus Jens Ø , Teze David
Published: April 2023

Engineering glycoside hydrolases is a major route to obtain catalysts forming glycosidic bonds. Glycosynthases, thioglycoligases and transglycosylases represent the main strategies, each having advantages and drawbacks. Here, we show that an engineered enzyme from the GH84 family, the acid-base mutant TtOGA-D120N, is an efficient O-, N- and S-glycoligase, able to use S_(sp^3 ), O_(sp^3 ), N_(sp^2 ), and N_sp nucleophiles. Moreover, TtOGA-D120N catalyzes the formation and release of N-acetyl-d-glucosamine 1,2-oxazoline, the intermediate of hexosaminidases displaying substrate-assisted catalysis. This release of an activated intermediate allows cascade synthesis by combination with transglycosylases or glycosynthases, here exemplified by synthesis of the human milk oligosaccharide lacto-N-triose II.
Triplet-Sensitized Bidirectional Isomerization of Bridged Azobenzene
Authors: Isokuortti Jussi , Griebenow Thomas , von Glasenapp Jan-Simon , Raeker Tim , Filatov Mihail A. , Laaksonen Timo , Herges Rainer , Durandin Nikita A.
Published: April 2023

Diazocine is a bridged azobenzene with both phenyl rings connected by a CH2-CH2 group. Despite this rather small structural difference, diazocine exhibits improved properties over azobenzene as a photoswitch, such as high switching efficiencies, very high quantum yields, switching wavelengths in the visible range, and most importantly, the fact that it is more stable in the Z configuration, which is particularly expedient in photopharmacology and mechanophore applications. According to our studies presented here, another advantage over conventional azobenzene is now added. In contrast to azobenzenes and other photochromes, diazocine can be switched with two different triplet sensitizers present at the same time in both directions: Z→E as well as E→Z. Experimental and theoretical (CASPT2) studies of triplet excitation energies provide an explanation for this fact. The triplet energies in Z and E azobenzene are almost equal, which prevents selective sensitization of either isomer. In diazocine, the two excitation energies are well-separated, so they can be accessed selectively. Besides offering fundamental physical insight to diazocines, an emerging class of photoswitches, our work opens up a number of potential avenues for utilizing them for example in photopharmacology and smart materials design due to the significant redshift of excitation wavelengths to from blue to green (Z→E) and green to far-red (E→Z), which triplet sensitization offers.
Polyelectrolyte Complex Hydrogel Scaffoldings Enable Extrusion-based 3D Bioprinting of Low-Viscosity Bioinks
Authors: Gockler Tobias , Li Defu , Grimm Alisa , Mecklenburg Felix , Grün Michael , Schepers Ute , Srivastava Samanvaya
Published: April 2023

We generate self-assembled biocompatible scaffolds with excellent structural integrity based on complex-forming block polyelectrolytes that enable extrusion-based 3D bioprinting of large constructs from low-viscosity bioinks. Despite remarkable progress of biofabrication techniques in tissue engineering, the development of extrudable bioinks that perform optimally at physiological temperatures remains a major challenge. Most biopolymer and photocurable precursor solutions exhibit low viscosities at 37 °C, resulting in undesirable flows and loss of form prior to chemical crosslinking. Temperature-sensitive bioinks, such as gelatin methacryloyl (GelMA), can be deposited near their gelling point, but suffer from suboptimal temperature-induced pre-gelation, poor cell viability emerging from long holding times in the cooled cartridges, inefficient temperature transfer from the print bed, and discontinuous layer-by-layer fabrication. Here, we demonstrate that block polyelectrolyte additives serve as effective viscosity enhancers when added to non-extrudable precursor solutions. Rapid, electrostatic self-assembly of block polyelectrolytes into either jammed micelles or interconnected networks provides hydrogel scaffoldings that form nearly instantly, lend initial structural robustness upon deposition, and enhance shear and tensile strength of the cured bioinks. Moreover, our approach enables continuous extrusion without the need of chemical crosslinking between individual layers, paving the way for fast biomanufacturing of human-scale tissue constructs with improved inter-layer bonding.
Headache on the background of coronavirus infection: features of the clinical picture
Authors: Feshchenko Daryna , Malyk Svitlana , Shevnia Mykola
Published: April 2023

Introduction. Covid-19 has become a new problem of our time. Incidence in the world is rapidly increasing, and with it, attention to the study of the mechanisms of virus pathogenesis is increasing. New symptoms of SARS-CoV-2 persistence in the human body appear. It has been established that not only respiratory manifestations are observed in infected person, but neurological symptoms are increasingly coming to the fore. The main and common manifestation of Covid-19 infection is a headache in the pre- and post-Covid period. Determining the possible routes of entry of the pathogen into the nerve cell, establishing the specifics of Covid-associated headache remains an urgent problem in medicine. The aim of the study. To analyze the data of the world scientific literature regarding the possible mechanisms of invasion of the SARS-CoV-2 virus into the nervous system and their influence on the development of headache in the pre- and post-covid period. Materials and methods. A retrospective analysis of the literature of scientific databases Scopus, PubMed, MedLines, Web of Science for 2020-2022 was carried out. Results. The latest data of the researchers indicate the neurovirulence of the pathogen. SARS-CoV-2 infects humans using the angiotensin-converting enzyme 2 (ACE2) receptor, which is present in the olfactory region, cerebral cortex, basal ganglia, hypothalamus, brain stem, and endothelial cells. The detailed mechanisms of penetration into the central nervous system (CNS) have not yet been fully understood, but the following transmission routes are considered: through the olfactory nerve, the brain is subsequently affected, the second route is cellular invasion, infected monocytes and macrophages, which are a reservoir for the virus for further distribution to other tissues, the next mechanism is infection of endothelial cells of the blood-brain and epithelial blood-liquid barrier. The researchers explain the mechanism of the appearance of headache due to the direct invasion of the endings of the trigeminal nerve in the nasopharyngeal cavity, which leads to the activation of the trigeminal vascular system. Headache is observed at the beginning of the disease and can last more than 180 days after recovery. It is characterized as bilateral, compressive in nature, lasts for hours, resistant to conventional painkillers, intensifies in the morning, with coughing and physical activity. Conclusions. The SARS-CoV-2 virus causes infection using ACE2 receptors, some of which are localized in different parts of the central nervous system, causing neurological symptoms. Headache is one of the most pronounced symptoms of COVID-19, its characteristics and evolution may reflect various pathophysiological mechanisms, which makes their study necessary for a more thorough understanding of headache in the pre- and post-сovid period and the search for options for its elimination.
Momentos clave en el camino hacia la equidad en salud en la Organización Panamericana de la Salud
Authors: Sena Ana Gabriela N. , Schutt-Aine Jessie , Arenas Jose , Akaba Selinam
Published: April 2023

Hoy en día la equidad es un objetivo central para la Organización Panamericana de la Salud (OPS). Este objetivo es el resultado de movimientos multidimensionales que tienen una historia y que sólo pueden comprenderse a la luz de las relaciones sociales que estructuran los procesos que llamamos de “salud”. De una preocupación por el comercio marítimo a un interés por los determinantes sociales de la salud, la OPS ha fortalecido sus esfuerzos por poner en el centro de sus acciones la idea de la equidad en salud como fin último. Se ha pasado de una idea de salud enfocada en el individuo, a una idea de salud para todas las personas, que contemple las diferencias de ser y hacer en el mundo. Estos cambios han producido políticas, análisis y estudios donde el género y la diversidad cultural son ejes transversales que deben ser contemplados en toda planificación y ejecución de políticas de salud en la Región de las Américas. En este artículo se analizan momentos clave en el camino hacia la equidad en salud en la Región desde una perspectiva histórica.
THE PROFESSIONAL GUIDANCE WORK: MODERN APPROACHES (FROM THE EXPERIENCE OF ACTIVITIES OF THE JOURNALISM AND NEW MEDIA DEPARTMENT AT BORYS GRINCHENKO KYIV UNIVERSITY)
Authors: Dosenko Anzhelika , Pastushyna Vasyl
Published: April 2023

Conducting career guidance work is an important stage in the formation of a competent contingent of students for every modern institution of higher education. The scientific work analyses modern methods of career guidance work from the experience of the Department of Journalism and New Media of the Institute of Journalism at Borys Hrinchenko Kyiv University. The winning vector of the work is considered by the authors as one that is aimed at helping young people and is designed to help make a certain choice of future profession, to identify special abilities and talents of high school students aimed at the media industry. The scientific article considers the methods of conducting professional activities of professionally-oriented work, namely: webinars, workshops, media festivals, which during 2020 and 2021 the department conducts as traditional. Attention is paid to online meetings with entrants and their parents, the programmes of events are analysed, a system of practical tasks, master classes from practitioners’ media are presented. The aim of the scientific article is to study the existing effective concepts of formation of career guidance work of the Department of Journalism and New Media at BGKU. During the period of 2020-2021, the Department of Journalism and New Media conducts active career guidance work among high school students, actively cooperates with media schools, school editorial offices and circles of the YUN-PRESS Information and Creative Agency. The general policy of the department is not focused only on Kyiv, but forms a target audience from all over Ukraine. This is confirmed by the number of participants in marathons and webinars-workshops from different cities of our country: Kryvyi Rih, Dnipro, Kropyvnytskyi, Poltava, Kharkiv, Khmelnytskyi, etc. This format became possible in the conditions of distance learning, which made it possible to expand the geography and made it possible to conduct online meetings.
INTERNATIONAL ACTIVITY OF THE DEPARTMENT OF LIBRARY SCIENCE AND INFORMOLOGY OF THE INSTITUTE OF JOURNALISM AT BORYS GRINCHENKO KYIV UNIVERSITY
Authors: Stambol Ihor
Published: April 2023

The article examines the main milestones in the development of international activities of the Department of Library Science and Informmology of the Institute of Journalism at Borys Grinchenko Kyiv University in 2016–2021. The participation of teachers and students of the department in international academic mobility programmes, as well as in international research projects is analysed. Indicators for the development and submission of grant applications are demonstrated, in particular with regard to the winning applications. The scientific publications of the teachers of the department, which were published in the publications indexed in the scientometric databases “Scopus” and “Web of Science”, are analysed. Generalised data on the participation of teachers and students of the department in Ukrainian and international scientific conferences are presented.
BEDEN VE BENLİK İLİŞKİSİ: TEORİK BİR DEĞERLENDİRME
Authors: BOZKURT Recep , KOYUNCU Ahmet Ayhan
Published: April 2023

“Ben kimim” sorusuna verilen yanıtlara karşılık gelen benlik, bedende cisimleşir. Benlik zorunlu olarak bir bedene ihtiyaç duyar. Bu çalışma, fenomenolojik beden merkezli bir okuma yapılmak suretiyle beden ve benlik arasında nasıl bir ilişki olduğuna odaklanmaktadır. Bu doğrultuda, beden ve benlik arasındaki ilişkiyi değerlendirebilmek için fenomenolojik beden yaklaşımında bedenlenme, canlı beden ve bilinçli beden ile sosyal psikoloji ve sembolik etkileşimcilikteki benlik kavramının yanı sıra Anthony Giddens’ın refleksif benlik kavramı bir zemin olarak kullanılmaktadır. Bu çalışmanın amacı; beden ve benlik arasındaki ilişkiyi betimlemektir.
CRYPTOGRAPHIC METHOD TO ENHANCE DATA SECURITY USING RSA ALGORITHM AND MELLIN TRANSFORM
Authors: Thakkar Akash , Gor Ravi
Published: April 2023

Cryptography is the technique of using mathematical algorithms to encrypt and decrypt the information. The process of converting plaintext to ciphertext is known as encryption, whereas the process of converting ciphertext to plaintext is known as decryption. Encryption and decryption methods based on Mellin Transform are unable to provide more security while transmitting the information. RSA algorithm is an Asymmetric key cryptography algorithm. The purpose of this study is to present a cryptographic method that uses the RSA algorithm and Mellin Transform to improve communication security.
ADOLESCENTS’ CAREER ANXIETY DURING THE COVID-19: THE ROLE OF FAMILY SUPPORT, HOPE AND CAREER DECISION-MAKING
Authors: ŞAMA ÇİÇEK Havvane , ZEREN Şerife Gonca
Published: April 2023

It is estimated that people from all age groups were affected by the COVID-19 pandemic. In this study, the career anxiety of adolescents, who needed to make career choices and decisions about their lives, while the pandemic was in
full swing was researched. Throughout this study, the career anxieties of adolescents were examined according to gender, career decision-making, whether COVID-19 had any affects on family relations, grade levels, and the perceived
success and income status of their families, as well as to the extent that family support, hope and career decision-making predicted career anxiety. A total of 713 adolescents, which consisted of 355 females and 358 males, aged
between fourteen and eighteen, attending high school in Turkiye participated in the study. As a result of the study, the following was found: career anxiety was significantly higher in females than in males; those who did not make
a career decision suffered more career anxiety than those who did; those whose family relations were affected by the COVID-19 pandemic suffered more career anxiety than those whose were not; and that those who were closer to graduating
from high school, those in the lower classes, and those with low family income suffered more career anxiety than others. In addition, there is a correlation between the career anxiety of adolescents and gender, career decision-making,
familial support and hope. It was concluded that a family's information support, family expectation, motivation to act and career decision-making predict career anxiety.
INVESTIGATION OF ADULTS' USE OF SOCIAL MEDIA AS AN EDUCATIONAL TOOL WITHIN THE FRAMEWORK OF THE USES AND GRATIFICATIONS THEORY
Authors: Duman Emel , Baltacı Şehnaz
Published: April 2023

This study aimed to determine the main motivations affecting adults' use of social media as an educational tool within the framework of the uses and gratifications theory. Among the factors motivating individuals to use social media,
the information acquisition factor was examined in the study. In this context, it was aimed to reveal the sub-factors affecting individuals' use of social media for information acquisition. The phenomenology design, one of the
qualitative research methods, was used in the study. The data were collected using a semi-structured interview form; some interviews were conducted face-to-face while some were by phone. The criterion sampling method was used to
determine the study group. The study group consisted of five adults over 18 who use social media for information acquisition. The results were analyzed by the content analysis method. As a result of the study, six sub-factors affecting
adults' use of social media for information acquisition were obtained. They were time-saving, convenience (accessibility in case of need, physical accessibility), up-to-date information, diversity of information, information sharing
(interaction, content production), and flexibility (choice of personal data, time, place).
MEVDUAT FAİZ ORANLARININ ARİMA YÖNTEMİ İLE TAHMİNİ: 2010-2022 DÖNEMİ TÜRKİYE UYGULAMASI
Authors: ŞAHİN Cumhur
Published: April 2023

Finansal verilerin en dikkate değer özelliklerinden biri zamana bağlı biçimde bir dizi teşkil etmeleridir. Bundan ötürü zaman serilerinin unsurları, söz konusu verilerin ifade ettiği ekonomik ve finansal parametreler hakkındaki bilgiyi de kapsamaktadır. Finans çalışmalarında değişkenlere ilişkin öngörü ya da tahmin hayati bir öneme sahiptir. Finansal değişkenlerin doğru, sağlıklı tahmin edilebilmesi, finansal piyasalardaki paydaşların açısından vazgeçilmez bir durumdur. Tahmin yapmada en sık kullanılan yöntemlerden birisi de ARİMA modelidir. Auto Regressive Integrated Moving Average (Otoregresif entegre hareketli ortalama) (ARIMA) modeli, tek değişkenli zaman serisi verilerini, transfer fonksiyonu verilerini ve ayrıca müdahale verilerini eşit şekilde dağıtan verilerde analiz ve tahminler için kullanılmaktadır. ARIMA yöntemi, ilk olarak Box ve Jenkins (1976) tarafından açıklamıştır, bu nedenle ARIMA modelleri genellikle Box-Jenkins modelleri olarak anılmaktadır. Bu çalışmada 2010-2022 yılı arasındaki dönem itibariyle Türkiye’de 1 yıl vadeli TL mevduat faiz oranları ARİMA yöntemi ile tahmin edilmeye çalışılmıştır. Analiz sonuçlarına göre araştırmada kullanılan Box-Jenkins (ARIMA) modelinin geçerli olduğu sonucuna varılmıştır. ARIMA (1,1,1) modelinin hem model uyum düzeyi ve modelin açıklama gücü, hem de tahmin değerleri ile gerçek değerler, modelin tahminde kullanılabilecek en doğru sonuçları veren, sağlam ve güvenilir bir model olduğunu gözlenmiştir.
Government Education Budget and the Sustainability of Student Enrollment in Public Secondary School in Bungoma County, Kenya
Authors: Wasilwa Juma Bakari  , Julius Maiyo  , Duncan Wasike
Published: April 2023

In Kenya, since 2008, the government has increased monies going to the education sector in collaboration with other foreign organizations in an effort to reduce the amount of money that households spend on their children who attend public secondary schools. In public secondary schools in Bungoma County, Kenya, this study aimed to determine how much the average government education spending affects the sustainability of student enrollment in secondary schools. A descriptive survey design was used for the investigation. The principals and household heads from Bungoma County's public secondary schools made up the target population. The 691 school principals and household heads in this study were chosen using a stratified random sampling procedure to ensure that the sample was representative. As instruments for gathering data, questionnaires, schedules for interviews and observations, and document analysis were all used. Expert judgment was used to determine validity. Through piloting, reliability was established. Statistics, both descriptive and inferential, were used to analyze the data. According to this survey, a secondary school student's Kshs 10,265 allowance is insufficient to keep them in school. According to the study's findings about government spending on each student, more students are enrolling in secondary school as government spending rises. As a result, this study suggests that, in order to raise the enrollment rate of pupils, the government or other educational stakeholders can assist parents who have children in first grade in purchasing a school uniform.