bluuebunny/crossref_metadata_2025 huggingface dataset:
РЕГІОНАЛЬНИЙ АСПЕКТ СПРЯМОВАНОСТІ НАУКОВО-ДОСЛІДНИЦЬКОЇ ДІЯЛЬНОСТІ МАЙБУТНЬОГО ВЧИТЕЛЯ ТЕХНОЛОГІЙ
Authors: Титаренко Ольга
Published: July 2024

У статті розглядаються регіональні особливості науково-дослідницької діяльності майбутніх вчителів технологій на Полтавщині. Проаналізовано поточний стан науково-дослідницької діяльності у Полтавському національному педагогічному університеті імені В.Г. Короленка, визначено основні чинники, що впливають на ефективність підготовки педагогічних кадрів. Особлива увага надається значенню матеріально-технічної бази, кваліфікації науково-педагогічного персоналу та ролі місцевих економічних, соціальних і культурних умов. Окреслено перспективи подальших досліджень, спрямованих на вдосконалення методологічних підходів, розробку інноваційних освітніх програм та підвищення міждисциплінарної інтеграції. Висвітлено важливість інтеграції результатів наукових досліджень у навчальний процес для підвищення якості освіти і професійної компетентності майбутніх вчителів технологій.
ІНСТРУМЕНТАРІЙ ЦИФРОВИХ ТЕХНОЛОГІЙ У СИСТЕМІ АНАЛІЗУ ВПЛИВУ STEM-ОСВІТИ НА ПСИХІЧНИЙ РОЗВИТОК МОЛОДШИХ ШКОЛЯРІВ В УМОВАХ ВОЄННОГО ЧАСУ
Authors: Алєксєєва Ганна , Черезова Ірина , Горецька Олена , Сердюк Наталія , Крючкова Юлія
Published: July 2024

Стаття аналізує використання інструментарію цифрових технологій для вивчення психологічного впливу STEM-освіти на психічний розвиток учнів початкової школи в умовах воєнного стану в Україні. У ході дослідження застосовано різноманітні цифрові інструменти, зокрема онлайн-опитування і аналітичні платформи, для збору даних про мотивацію, самооцінку, рівень стресу та соціально-психологічну підтримку учнів. Теоретичний аналіз і емпіричні дані підтвердили значний позитивний вплив STEM-освіти на наукове мислення та практичні навички учнів, їх інтерес до навчання і розвиток критичного мислення.
Особлива увага у дослідженні надається аналізу гендерних та вікових відмінностей у відповідях учнів, що вказує на необхідність адаптації освітніх методик для врахування цих розбіжностей. Зокрема, результати опитувальника STEM-Kids Motivation Survey підтвердили високий загальний інтерес до STEM-дисциплін, хоча дівчата та хлопці проявляють інтерес до різних аспектів цих наук. Також використання “Шкали навчального стресу для дітей” показало, що молодші учні переживають менший стрес порівняно з учнями старших класів, що може бути зумовлено більшими академічними викликами для останніх.
ОРГАНІЗАЦІЯ ДОСЛІДНИЦЬКОЇ ДІЯЛЬНОСТІ ШКОЛЯРІВ У ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОМУ ОСВІТНЬОМУ СЕРЕДОВИЩІ ЗАКЛАДІВ ЗАГАЛЬНОЇ СЕРЕДНЬОЇ ОСВІТИ
Authors: Стахів Лілія , Волошин Сузанна , Прийма Андрій
Published: July 2024

Актуальність дослідження проблеми організації дослідницької діяльності школярів у здоров’язбережувальному освітньому середовищі закладів загальної середньої освіти продиктоване нововведеннями, пов’язаними із впровадженням ідей Концепції Нової української школи. У контексті дотримання принципів Державних стандартів початкової та базової середньої освіти відповідно до цієї Концепції здійснено аналіз нормативно-правових документів та навчально-методичного забезпечення, за яким здійснюється освітній процес з учнями молодшого та середнього шкільного віку, а також розкрито методику організації дослідницької діяльності з учнями під час проведення занять “Я пізнаю світ” (4 клас) та “Пізнаємо природу” (5 клас).
РОЗВИТОК У МАЙБУТНІХ ФАХІВЦІВ ІНЖЕНЕРНО-ПЕДАГОГІЧНИХ СПЕЦІАЛЬНОСТЕЙ НАВИЧОК МОДЕЛЮВАННЯ ПРИ ВИКОНАННІ STEM-ПРОЄКТІВ
Authors: Деревянчук Олександр
Published: July 2024

У статті розглядається застосування моделювання багатогранників у рамках STEM-проєктів для підготовки майбутніх фахівців інженерно-педагогічних спеціальностей. Активне включення 3D-моделювання у освітній процес спрямоване на інтеграцію наукових знань, технологій, інженерії та математики через виконання практичних завдань та реальних інженерних викликів. Моделювання багатогранників, зокрема, дає змогу глибше зануритись у вивчення властивостей геометричних фігур, їхньої симетрії та пропорцій, що сприяє не лише засвоєнню абстрактних математичних концепцій, але й розвитку логічного і просторового мислення. Особлива увага приділяється проєкту “Моделювання просторових зображень багатогранників”, що включає аналіз, покрокове створення моделей в AutoCad, застосування програмних інструментів для 2D- і 3D-проєктування та друк моделей на 3D-принтері.
АВТОРСЬКЕ ТРАКТУВАННЯ АНГЛІЙСЬКОЇ ПАРКОВОЇ КОМПОЗИЦІЇ ДІОНІСОМ МАККЛЕРОМ НА ПРИКЛАДІ ПАРКІВ ПОДІЛЛЯ
Authors: Халайцан Володимир
Published: July 2024

У статті розглянуто авторські підходи до побудови ландшафтів видатного ландшафтного архітектора Діоніса МакКлера. Виявлено, що в своїх роботах, митець активно застосовував як композиційні рішення, властиві європейському ландшафтному мистецтву загалом, так і суто орієнтальні підходи до утілення авторського задуму в планувальній структурі парку. Відтак композиційні структури творінь Д. МакКлера досягають особливої виразності.
Досліджуються витоки майстерності архітектора, його творчий доробок, в умовах полікультурної та багатовекторної суспільно-політичної формації краю XVIII–XIX ст., що ґрунтувалась на ментальному наративі кресової шляхти. З’ясовуються впливи геологічних, рельєфних, кліматичних чинників на хід творчої думки Д. МакКлера й виробленню ним особливого стилю композиційної побудови паркових структур. Утілені ландшафтним архітектором задуми, свого часу послугували утворенню характерного образу парку, що є цікавими для вивчення і гідними взірцями ландшафтного мистецтва й донині.
Déficits y excesos normativos en materia de transparencia, buena administración y buen gobierno: un análisis de la cuestión a partir de la legislación estatal y extremeña
Authors: Tahirí Moreno Jesús A. , Cofrades Aquilué Lucía
Published: July 2024

Objetivos: realizar una revisión crítica del estado de la cuestión en materia de transparencia, buena administración y buen gobierno con ocasión del décimo aniversario de la aprobación de la Ley 19/2013, de 9 de diciembre. Metodología: con la finalidad de construir un estudio sistemático y completo del tema tratado, la investigación se lleva a cabo mediante un análisis legal, doctrinal y jurisprudencial de los elementos que afectan a dos pilares clave de las políticas públicas de gobierno abierto: la transparencia y la colaboración (concepto este último que comprende la integridad y la rendición de cuentas o accountability). Además, se analiza el impacto del principio de buena administración en el procedimiento administrativo a la luz de la jurisprudencia más reciente. El método empleado es el comparativo, tomándose como muestra la normativa estatal y la extremeña. Resultados: la investigación constata diversos déficits y excesos que convendría tener presentes en futuras reformas legislativas, tanto a nivel estatal como autonómico. Conclusiones: se considera necesario realizar una modificación de la Ley 19/2013, de 9 de diciembre con la finalidad de integrar la jurisprudencia de la Sala Tercera y depurar defectos de técnica normativa. Asimismo, se concluye que sería adecuado regular un régimen de acceso especial a la información pública aplicable a aquellos sujetos que juegan un papel determinante en la formación de la opinión pública. A nivel autonómico, como conclusión principal, se recomienda llevar a cabo una refundición de la legislación en materia de transparencia y buen gobierno. Por lo que respecta a la buena administración, sería conveniente –siguiendo la CDFUE, la normativa autonómica y la jurisprudencia del Tribunal Supremo– que el legislador estatal reconociera expresamente el derecho a una buena administración. Finalmente, se critica la técnica empleada para regular los principios de buen gobierno y los códigos de conducta, así como la inexistencia de evaluaciones objetivas y obligatorias que permitan conocer su grado de cumplimiento.
Exploring Research on the Expression Area of Elementary School Physical Education Subjects during COVID-19
Authors: Lee Kangsoon ,   Gyeongin National University of Education
Published: July 2024

This study aims to explore previous research on the expression area of elementary school physical education subjects in the COVID-19 situation. Accordingly, we consider the direction of research in the expression area of non-face-to-face classes that have replaced face-to-face classes. Moreover, this study anticipates the stabilization and sharing of various teaching methods by supplementing existing online classes at present and the smooth progression of expression area classes. This study is a literature review on the Korean Journal Citation Index (KCI), a system that analyzes citation relationships between papers by converting journal information, paper information, and references from academic organizations publishing academic journals registered (candidate) by the National Research Foundation of Korea into a database. Data were collected and analyzed from KCI. The findings are as follows. First, in expression research, various methods have been investigated to conduct classes appropriately by combining the advantages of existing face-to-face classes prior to the COVID-19 period and non-face-to-face classes using online devices during the COVID-19 era. Second, to ensure that classes in the area of expression run smoothly, research was conducted on restructuring and re-systemizing the curriculum so that online classes and physical activity-centered offline classes can run concurrently. Furthermore, research was conducted to develop teaching methods for online and offline expression areas, research content, and a platform to use teaching content. Such method will be disseminated for implementation.
Emotional Capital and Compassionate Educational Space: Reflection on One Undergraduate Course
Authors: Bodovski Katerina
Published: July 2024

In this essay, I reflect upon my experience of creating and teaching a new undergraduate course, Students, Parents, Schools. I look at the course content and process through the lens of emotional capital. While being one of the themes in the course, emotional capital is also developed for the students within the class itself. I identified four aspects of the course that can be linked to building emotional capital: bringing focus to oneself; encouraging students to capitalize on their own experiences; building meaningful connections; and creating a non-punitive environment. I discuss each of the aspects, illustrating them where appropriate with students’ anonymous feedback. I reflect upon the importance of strengthening one’s emotional capital for our undergraduate students in general, and for our future teachers, in particular.
"A Life Altering and Special Journey": The Lasting Impact of Mindfulness on Semester-long Study Abroad Participants
Authors: Conboy Ana , Clancy Kevin
Published: July 2024

Education abroad is held up as a high-impact practice with the potential to engage college and university students in a transformative learning experience (Kuh, 2008). The Institute for International Education (IIE) reports that 347,099 U.S. students received academic credit for study abroad during the 2018-2019 academic school year (IIE). Extensive research into student learning gains abroad have demonstrated that developing student metacognition, or one’s ability to be intentionally self-reflective, is central to transformative learning in the study abroad experience (Vande Berg et al., 2012; Zull, 2012). Consequently, international educators are continually searching for pedagogies (praxis) to facilitate metacognitive learning within study abroad programs. The burgeoning discipline of contemplative pedagogy (Bai et al., 2009; Zajonc, 2013) provides such a praxis for metacognitive learning. Yet the research on the use of contemplative pedagogy within the context of study abroad is still in a nascent stage (Clancy, 2020). In this paper, we present an exploratory case study of contemplative pedagogy and mindfulness practice on a semester-long study abroad program and, namely, its potential long-term impact on student participants. Analysis of questionnaires, answered on a voluntary and anonymous basis, 18 months after the return to the home campus, reveals that students continue to use those practices: Students report sustained attentiveness to surroundings, in the present moment, greater self-awareness, improved connection to those in their communities, and a heightened remembrance. We conclude that contemplative pedagogy, associated with student metacognition, was a successful intercultural praxis within the exploratory case study, and may potentiate long-term effects in participants.
Resenha do livro: Nardi AE, da Silva AG, Quevedo J. Tratado de Psiquiatria da Associação Brasileira de Psiquiatria
Authors: Sousa Eduardo Morales , Fischer Audrey Ribeiro , Rocha Klaus Kirch Nienkotter , Carvalho Luiza Rabello de Paula , Goldberg Neto Mauricio , Roma Pedro Fernandes
Published: July 2024

Sumário do Livro
Apresentação
Prefácio
Parte 1. Fundamentos
Capítulo 1. Uma breve história do conhecimento psiquiátrico e de suas implicações para a prática
Capítulo 2. Ética na psiquiatria
Capítulo 3. Religiosidade, espiritualidade e transtornos mentais
Capítulo 4. Aspectos epidemiológicos dos transtornos mentais
Capítulo 5. Fundamentos e análise estatística de desenhos experimentais em psiquiatria
Capítulo 6. A psiquiatria no sistema de saúde
Capítulo 7. O estigma dos transtornos mentais
Capítulo 8. Desenvolvimento normal da criança e do adolescente
Capítulo 9. Aspectos genéticos em psiquiatria
Capítulo 10. Neuroanatomia funcional
Parte 2: Diagnóstico
Capítulo 11. Histórico do diagnóstico e classificações atuais
Capítulo 12. Entrevista psiquiátrica, exame clínico e exame do estado mental
Capítulo 13. Psicopatologia geral
Capítulo 14. Instrumentos de avaliação em psiquiatria
Capítulo 15. Avaliação neuropsicológica em psiquiatria
Capítulo 16. Exames de laboratório em psiquiatria
Capítulo 17. Estudos de imagem em psiquiatria
Parte 3. Transtornos psiquiátricos
Capítulo 18. Transtornos do neurodesenvolvimento e transtorno do espectro autista
Capítulo 19. Espectro da esquizofrenia e outros transtornos psicóticos
Capítulo 20. Transtorno bipolar
Capítulo 21. Transtornos depressivos
Capítulo 22. Suicídio: epidemiologia, risco e prevenção
Capítulo 23. Transtornos de ansiedade
Capítulo 24. Transtorno obsessivo-compulsivo e transtornos relacionados
Capítulo 25. Transtornos relacionados a trauma e a estressores
Capítulo 26. Transtornos alimentares
Capítulo 27. Transtornos somatoformes, dissociativos e factício
Capítulo 28. Transtornos mentais secundários a doenças orgânicas
Capítulo 29. Transtorno por uso de álcool
Capítulo 30. Transtornos por uso de substâncias
Capítulo 31. Disfunções sexuais, parafilias e transtornos parafílicos e disforia de gênero
Capítulo 32. Transtornos do sono-vigília
Capítulo 33. Transtornos do controle de impulsos
Capítulo 34. Transtornos neurocognitivos e demências
Capítulo 35. Transtorno de déficit de atenção/hiperatividade
Capítulo 36. Transtornos da personalidade
Capítulo 37. Interconsulta psiquiátrica
Capítulo 38. Emergências psiquiátricas
Parte 4. Tratamentos
Capítulo 39. Psicofarmacologia
Capítulo 40. Terapias de estimulação cerebral não invasiva
Capítulo 41. Terapias de estimulação cerebral invasiva
Capítulo 42. Psicoterapias
Capítulo 43. Transtornos psiquiátricos em mulheres
Capítulo 44. Psiquiatria da infância e adolescência: princípios gerais
Capítulo 45. Transtornos cognitivos e demenciais associados ao envelhecimento
Capítulo 46. Psiquiatria forense
Effect of Different Modification Techniques on Mechanical and Physical Properties of E-Max CAD Substrate
Authors: Hussein Abdulsattar Marwah , Hussein Jasim Alaa
Published: July 2024

The world's best-selling glass-ceramic is IPS E.Max CAD. It is known for its versatile applications and is appropriate for the effective manufacturing of comprehensive dental restorations. This experimental study aimed to evaluate the morphological changes, surface roughness, and micro-hardness after modification techniques with KHF2 and NH4HF2 acid etching on e-max cad substrate.
Materials and Methods: Forty disc shape of E.Max CAD specimens (thickness 3mm and diameter 10mm) were fabricated and divided into four groups according modification techniques (control group, sandblasting by 70µm of Al2O3, etching with 70 mg of KHF2 and etching with 70mg of NH4HF2),10 samples for each group. Surface roughness, micro-hardness, and microstructure changes of e-max CAD substrate have been measured.
Results: The higher mean value for the surface roughness (Ra) was in the group (ECNH4HF2), followed by (ECKHF2) whereas the lowest mean value of surface roughness was in the group (ECC) followed by (ECSB). While for the micro-hardness test, the (ECKHF2) group demonstrated the highest mean value in comparison with other treated groups. Finally, SEM results for both untreated and sandblasted groups revealed there is a smooth and no deep morphological change for their surfaces. While the SEM analysis revealed that the e-max cad surfaces after KHF2 and NH4HF2 showed rough morphology with fine grains result and random porosities.
Conclusions: Etching with KHF2 and NH4HF2 yielded higher microstructure changes and roughness than other techniques. While KHF2 etchant was more effective on E.Max CAD surface micro-hardness in comparison with other treated groups.
Treatment of Dentine Hypersensitivity with Diode Laser
Authors: Sh. Rajab Muthenna , A. Anai Tamara , Ammar Ahmed Zainab , Abed Khamees Saad
Published: July 2024

Patient discomfort due to dentin hypersensitivity DH is one of the major challenges faced by dentists in daily practice. Difficulties in DH treatment have resulted in the many regimens currently used. This clinical study aimed to evaluate the effectiveness of a new protocol in reducing dentin hypersensitivity using a 980 nm diode laser.
50 cases of DH were enrolled in the study, and the pain level was assessed using the Visual Analog Scale (VAS) Apply a 980 nm diode laser with continuous mode, backward motion, tangential incidence of the beam in non-contact mode and 0.7 W delivered output with a total exposure time of 60 s per tooth. Postoperative pain was significantly reduced immediately after treatment. Means remained stable until the 2-week follow-up.
Aligning Archwires in Orthodontics: Exploring the Past, Present, and Future - A Comprehensive Narrative Review
Authors: Khairullah Ahmed Omar , Salim Kadhum Ammar
Published: July 2024

Orthodontic wires facilitate the required dental adjustments in the context of orthodontic therapy. The archwire has played a crucial role in orthodontic treatment, and the increasing emphasis on aesthetic preferences from patients, as well as the development of composite and ceramic brackets, have prompted investigations into aesthetic archwires that complement these brackets. Orthodontic wires are produced using a diverse range of materials. The utilisation of all available wire types can improve patient comfort, decrease chairside time, and shorten the overall duration of treatment. The individual clinician must possess comprehensive knowledge and comprehension of the various requirements and alternatives throughout the therapeutic process. This article provides an overview of the history of materials utilised in producing orthodontic aligning archwires, the latest advancements in these materials currently accessible in the market, and the future of archwire production.
Characteristics of Gubernacular Canal of Impacted/ Unerupted Canine in Relation to Eruption Status by Using CBCT
Authors: S. Almoosa Tiba , M. AL-Khatieeb Mustafa
Published: July 2024

To evaluate detection rates and morphology of gubernacular canal (GC) in impacted/ unerupted canine, and to determine whether there is a difference in GC characteristics between impacted and unerupted canine.
Subjects and Methods: By using CBCT, GCs were retrospectively analyzed in 300 patients with 432 impacted/ unerupted canine (96 males, 204 females; Age range, 7 to 54 years). Each imaging system software was first converted the CBCT pictures to volumetric data, from which reconstructions on multiple planes were done. Axial, sagittal, and coronal views were provided for each CBCT exposure. Furthermore, coronal sections and corrected sagittal were ready to assess all impacted/ unerupted canines for the presence of GCs, alteration in shape of GC, opening site of GC in the alveolar crest, attachment site of GC to the dental follicle, and canine eruption status. Results: The normal or delay eruption status of canines had high detection rate which were 95.9% and 100% respectively, unlike the impacted canine which had a low detection rate which was 71.2%. Only 8.9% of detected GC had alteration in shape. 54.1% of GC opened palatal or lingual to alveolar crest, 21.9% of GC was continuous with periodontal ligament (PDL) of primary canine, 20.5% of GC opened in the center of alveolar crest, and 3.5% of GC opened Buccally. 59.1% of GC was unusually attached to dental follicle, and 40.9% of GC was usually attached to dental follicle. There was a high significant difference between canine eruption status and characteristics of GC.
Conclusion: The findings of this study reveal that the characteristics of GC in impacted/ unerupted canine may be a sign of an abnormal eruption condition.
PENGARUH PERBEDAAN LABA AKUNTANSI DAN LABA FISKAL,TINGKAT HUTANG, DAN UKURAN PERUSAHAAN TERHADAP PERTUMBUHAN LABA (Studi Empiris Perusahaan Manufaktur Sub Sektor Konsumsi yang Terdaftar di BEI periode 2019-2021)
Authors: Muchtamilatur Rochmah Dewi
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan laba akuntansi dan laba fiskal (Book Tax Differences), tingkat hutang, dan ukuran perusahaan terhadap pertumbuhan laba pada perusahaan manufaktur studi konsumsi. Dalam penelitian ini menggunakan metode kuantitatif dengan data sekunder. Sampel penelitian adalah laporan keuangan tahunan perusahaan manufaktur sub sektor konsumsi yang terdaftar di BEI periode 2019-2021. Teknik pengambilan sampel pada penelitian ini menggunakan teknik purposive sampling berdasarkan kriteria tertentu. Hasil penelitian ini menunjukkan bahwa perhitungan hipotesis secara parsial Book Tax Differences berpengaruh signifikan terhadap pertumbuhan laba dengan tingkat singnifikan sebesar 0.002 < 0,05. Tingkat hutang berpengaruh singnifikan terhadap pertumbuhan laba ditunjukan sengan tingkat signifikan sebesar 0.000 < 0.05. Dan ukuran perusahaan berpengaruh singnifikan terhadap pertumbuhan laba ditunjukan dengan tingkat signifikan sebesar 0.045 < 0.05. Untuk hasil pengujian secara simultan diperoleh 0.000 < 0.05 berarti pengujian hipotesis secara simultan antara Book Tax Differences, tingkat hutang dan ukuran perusahaan secara bersama-sama berpengaruh singnifikan terhadap pertumbuhan laba. Dari hasil penelitian ini juga diperoleh Koefisien Determinasi (R²) dengan nilai 0.395 memiliki arti bahwa sebesar 39,5% pengungkapan dijelaskan oleh variabel Book Tax Differences, tingkat hutang dan ukuran perusahaan sedangkan sisanya 60,5% dijelaskan oleh variabel lain diluar model.
Transport problem with transportation time constraint
Authors: Бахвалов С.В. , Маланова Т.В. , Янхаев Д.В.
Published: July 2024

В статье представлена модифицированная транспортная задача, в которой учитывается перевозка грузов от поставщиков к потребителям за несколько рейсов, причем весь товар должен быть доставлен в установленный срок. Авторы отдают предпочтение задачам линейного программирования в силу существования различных решателей, позволяющих найти решение существующими методами. В связи с этим была разработана математическая модель транспортной задачи, как задачи целочисленного линейного программирования, и предложено решение задачи в среде программирования Python с использованием библиотеки PuLP. Для наглядности рассмотрен простейший пример.
Decision making support in territory management based on the method of integral estimation of the life quality (in case of Krasnoyarsk region)
Authors: Алдошкина А.М. , Пенькова Т.Г. , Ноженкова Л.Ф.
Published: July 2024

В работе представлен подход к поддержке принятия решений в территориальном управлении на основе метода интегрального оценивания качества жизни. Предложена модель формирования управляющих рекомендаций на основе анализа текущего уровня качества жизни. Представлена платформа для мониторинга качества жизни в муниципальных образованиях региона и поддержки формирования рейтинговых оценок для измерения качества жизни в разрезе реализации национальных проектов. Представлены результаты оценивания качества жизни в муниципальных образованиях Красноярского края по данным за 2021 год.
Automating tools for the development and application of an applied microservices package
Authors: Опарин Г.А. , Богданова В.Г. , Пашинин А.А.
Published: July 2024

Представлены результаты, связанные с применением разработанного ранее метода булевых ограничений для исследования динамики и параметрического синтеза систем управления, в частности, булевых сетей, в микросервисной инфраструктуре с использованием методов и средств построения баз знаний. В качестве базы знаний выступает вычислительная модель предметной области, под которой понимается совокупность сведений об объектах предметной области и отношениях между ними. Каждое функциональное отношение реализуется вычислительным микросервисом, созданным на основе программного модуля, вычисляющего значения выходных параметров по заданным значениям входных параметров. Набор вычислительных микросервисов составляет функциональное наполнение пакета прикладных микросервисов. Системное наполнение составляют сервисы постановки задачи, планирования и мониторинга вычислений, управления данными, обработки результатов. Управление вычислениями (децентрализованное, централизованное или иерархическое) осуществляется агентами пакета прикладных микросервисов в зависимости от постановки задачи и способа организации базы знаний. В связи с переходом к исследованию новых классов булевых сетей (управляемых, сингулярных, неявных, асинхронных, двудольных и других) выполняется расширение созданного ранее на основе вышеизложенного подхода пакета прикладных микросервисов, предназначавшегося для задач качественного исследования автономных булевых сетей. Целью исследования является разработка нового инструментария микросервисной интеллектуальной вычислительной платформы HPCSOMAS-MSC для создания, настройки и доступа к вычислительным микросервисам, позволяющего взаимодействовать с микросервисами функционального наполнения напрямую через веб-интерфейс. Реализован веб-интерфейс описания предметной области в дополнение к существующему описанию на языке JSON. Новый инструментарий позволяет как ускорить разработку и отладку микросервисов, так и сделать дальнейшие взаимодействие более удобным для пользователя-предметника.
A Reusable Non-Complementary-DNA-Based Neural Network
Authors: Sun Chengjie , Liu Xiaoyang , Zhong Jiafeng , Zhou Qin , Cheng Jianjun
Published: July 2024

The emulation of intelligence across diverse domains of the human brain has spurred the development of neural network based artificial intelligence. The computation of the DNA-based neural network has recently emerged as a focal point of research due to its versatility, scalability, energy efficiency and potentially other huge benefits and implications, as compared to electronic computation. Despite notable advancements, the development of the current DNA neural networks, based on the complementary pairing of DNA nucleobases, is restricted by the lack of reusability of the DNA computing materials, one of key bottlenecks impeding their progression towards neural network learning and evolution. As a result, even the state-of-the-art DNA neural network computations are limited to one-time use currently. Here we report the design of an unprecedented, reusable DNA based non-complementary perceptron (NCP) strategy that implements thresholding and weighted summation functions like neurons and the corresponding neural networks capable of 4-bit molecular pattern recognition. To facilitate the scaling-up of the non-complementary circuits, a modulated concept employing “tagging” domains is also coined. We demonstrate that non-complementary “winner-take-all” circuit can be rationally constructed with a non-complementary annihilator strand. Such NCP based neural network architecture is capable of 4-bit pattern recognition, evidenced by its success in playing the “I Spy” game. Most importantly, when removable input strands (lipid-oligonucleotide conjugates) are utilized, this NCP-based pattern recognition neural network shows high fidelity in multiple-cycle computing. This suggests a reusable DNA based NCP computation strategy as a potential conceptual breakthrough for the design of next-generation DNA computers.
Electrochemical and digital simulation analyses of two-proton-coupled electron transfer between superoxide and hydroquinone
Authors: Nakayama Tatsushi
Published: July 2024

Electrochemical reduction of dioxygen (O2) in the presence of benzene-1,4-diol (hydroquinone) in N,N-dimethylformamide (DMF) was investigated using cyclic voltammetry and digital simulation techniques. Along the electrochemical reduction, a quasireversible cyclic voltammogram (CV) of O2 forming superoxide radical anion (O2•−) was modified in the presence of hydroquinone, where electrogenerated O2•− was scavenged by hydroquinone forming quinone radical anion and hydroperoxide with superior reaction kinetics via two-proton-coupled electron transfer (2PCET). Digital simulations of the CVs were conducted to clarify the details of 2PCET, where heterogeneous electrochemical reactions and homogeneous solution reactions between electrogenerated O2•− and hydroquinone are involved. As a result of the simulation analyses, thermodynamic and kinetic parameters for the 2PCET were obtained, which involved three elementary steps, (i) formation of the prereactive complex from the free reactants, (ii) intra-complex 2PCET forming the product complex via a transition state, and (iii) dissociation of the product complex yielding the free products. The obtained parameters provide fundamental and prerequisite information for the development of artificial electron transfer catalysts and electron transfer carriers using H2Q derivatives.
Sphingosine pathway as a possible druggable target for pain management
Authors: Swain Sharada Prasanna
Published: July 2024

Sphingolipids bear a spingoid base, and a fatty amino alcohol known as sphingosine. Sphingosine in converted to sphingosine phosphate (S1P) catalyzed by sphingosine kinase enzymes. S1P is transported across the plasma membrane and binds to extracellular S1P receptors. S1P is found in high concentration in plasma of patients with rheumatoid arthritis and at inflammation sites. Targeting S1P receptors might be a suitable strategy for discovery of drugs for treatment of neuropathic pain.
Plasmon Modulation in Copper Phosphide Nanocrystals
Authors: Yu Jiyuan , Chen Zifei , Zhang Heyou , Hutchison James , Mulvaney Paul , Ashokan Arun
Published: July 2024

We present the modulation of surface plasmon resonance in non-stoichiometric copper phosphide nanocrystals. This was achieved through control over the carrier concentration by an applied electrochemical potential. Application of anodic potential resulted in the blueshift of the plasmon resonance and increment in its extinction. Under cathodic potential, the plasmon redshifted and reduced the extinction. Further, these changes were reversible over multiple cycles of anodic and cathodic potential steps. We also discuss how the post synthetic ligand treatment can impact the plasmon peak and structure of Cu3−xP nanocrystals . Specifically, the treatment of thiols resulted in the decomposition of the nanocrystal. This work demonstrates how plasmon peak in Cu3−xP can be used as a probe to visualize the changes in the structure and carrier density of these nanocrystals in various applications.
Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions
Authors: Chang Han-Wen , Yang Chien-I , Chan Jerry Chun Chung
Published: July 2024

Studies of the structure and dynamics of oligomeric aggregates of amyloidogenic peptides pose challenges due to their transient nature. This concept article provides a brief overview of various nucleation mechanisms with reference to the classical nucleation theory and illustrates the advantages of incubating amyloidogenic peptides in reverse micelles (RMs). The use of RMs not only facilitates size regulation of oligomeric aggregates but also provides an avenue to explore protein–protein interactions among the oligomeric aggregates of various amyloidogenic peptides. Additionally, we envision the feasibility of preparing brain tissue-derived oligomeric aggregates using RMs, potentially advancing the development of monoclonal antibodies with enhanced potency against these pathological species in vivo.
pKa predictions for arsonic acid derivatives.
Authors: Nedyalkova Miroslava , Heredia Diana , Lattuada Marco , Barroso-Flores Joaquín
Published: July 2024

Food, water, air, and soil are regularly contaminated with natural and artificially occurring forms of arsenic, from which, arsonic acid derivatives RAsO(OH)2 are the major pentavalent compounds present in aqueous media. At a given pH, the resulting ionization state for these derivatives affects their lipophilicity, solubility, protein binding, and their ability to cross plasma membranes, potentially increasing their toxicity. Knowing their pKa values not only characterizes them but helps design a specific strategy for their bioremediation. There are numerous challenges associated with predicting pKa, and existing models are limited to certain chemical spaces. To leverage a pKa model for arsonic acids, we contrast machine learning (ML) methods based in Support Vector Machine and three DFT-based models: correlation to the maximum surface electrostatic potential (VS,max) at the ωB97XD/cc-pVTZ level of theory; correlation to carboxylate atomic charges in conjunction with a density-based solvation model (SMD) at the level of M06L/6-311G(d,p); and the scaled solvent-accessible surface approach, which yielded high mean unsigned errors for predicted pKa, and therefore it is not an efficient method for calculating the pKas of arsenic acids, in contrast with reported data for carboxylic acids, aliphatic amines, and thiols. The highest agreement was obtained with the atomic charges calculation on the conjugated arsonate base. ML based and Vs,max models rank second and third, respectively, in terms of prediction performance.
Enzyme-assisted electrochemical point-of-care test for miRNA detection towards liquid biopsy application
Authors: Kalligosfyri Panagiota M , Cimmino Wanda , Normanno Nicola , Cinti Stefano
Published: July 2024

Liquid biopsy enables emerging biomarkers detection, such as circulating tumor DNA (ctDNA), microRNAs (miRNAs), and exosomes, leading to real-time monitoring of cancer progression and therapy effectiveness. Important circulating miRNAs, serving as biomarkers, have been correlated to breast cancer (BC) metastasis and therapy efficiency. In particular, among the BC, the Triple negative BC (TNBC) is an aggressive and heterogeneous subtype, accounting for 40% of BC related mortality. Rapid detection of these miRNAs through non-invasive liquid biopsy can significantly enhance diagnosis and prognosis, thereby improving survival rates. Considering these emerging biomarkers within the framework of personalized medicine, affordable and portable devices could enable quicker monitoring for cancer patients, including those in remote areas. In this context, we have developed an enzyme-assisted electrochemical point-of-care (POC) test. The proposed miRNA detection system is boosted by the use of duplex-specific nuclease (DSN) as the recognition element of miRNA. The DSN enzyme exhibits high selectivity to discriminate DNA-RNA heteroduplexes triggering isothermal target recycling and signal enhancement. This capability is crucial for overcoming the limitations often associated with detecting trace amounts of miRNA in biofluids. In our study, the specific probe for the miRNA target was labelled with a redox mediator, methylene blue, to enable the detection of enzymatic products via electrochemical measurements on screen-printed electrode. Optimization studies have been performed to obtain the enzymatic reaction in terms of probe and enzyme concentration. A calibration graph was obtained for various target concentrations ranging from 0.1 pM to100 nM, and a detection limit down to the fM level was achieved. Specificity studies were performed with random miRNA targets, and finally the device was applied in spiked commercial serum samples. These promising results suggest potential for developing novel class of POC tests towards the realization of an all-in-one sustainable platform for liquid biopsy applications.
University Students’ Awareness of the Role of Culture in the Language Learning Process
Authors: Abdullah Nian
Published: July 2024

To learn English language and communicate in different contexts successfully, English language students need to learn about the culture of English native speakers in spite of mastering the linguistic knowledge of the language. Indeed, culture shapes the language just as it shapes the life of its speakers. However, it is unknown whether students are aware of the role of culture in the language learning process and in case they are aware, it is still not evident how they learn about the culture. To learn about these two aspects, the current study explores undergraduate students’ awareness in this regard. It uses a four-Likert scale questionnaire to elicit answers from 45 EFL junior students in English Department. The results demonstrated that the majority of students are aware of the role of culture on English language learning and they use different methods to learn about the culture. Their awareness can be exploited to make culture part of English language teaching programs at universities.
A large-scale cancer-specific protein–DNA interaction network
Authors: Lu Yunwei , Berenson Anna , Lane Ryan , Guelin Isabelle , Li Zhaorong , Chen Yilin , Shah Sakshi , Yin Meimei , Soto-Ugaldi Luis Fernando , Fiszbein Ana , Fuxman Bass Juan Ignacio
Published: July 2024

Cancer development and progression are generally associated with gene dysregulation, often resulting from changes in the transcription factor (TF) sequence or expression. Identifying key TFs involved in cancer gene regulation provides a framework for potential new therapeutics. This study presents a large-scale cancer gene TF-DNA interaction network, as well as an extensive promoter clone resource for future studies. Highly connected TFs bind to promoters of genes associated with either good or poor cancer prognosis, suggesting that strategies aimed at shifting gene expression balance between these two prognostic groups may be inherently complex. However, we identified potential for oncogene-targeted therapeutics, with half of the tested oncogenes being potentially repressed by influencing specific activators or bifunctional TFs. Finally, we investigate the role of intrinsically disordered regions within the key cancer-related TF ESR1 in DNA binding and transcriptional activity, and found that these regions can have complex trade-offs in TF function. Altogether, our study broadens our knowledge of the TFs involved in cancer gene regulation and provides a valuable resource for future studies and therapeutics.
Poço de potencial finito como átomos hidrogenóides
Authors: R. Armando Hudson , H. Abbehausen Kaue , S. Costa Caio , S. Barbosa Leonardo , L. Azevedo David
Published: July 2024

Neste artigo, resolvemos numericamente a equação de Schrödinger para um elétron sujeito a potencial caixa unidimensional de profundidade finita. Aplicamos este modelo amplamente explorado em física, aos átomos H, Li, Na e K da família 1A da tabela periódica, cujos elétrons na camada de valência possuem momento angular orbital l=0. A fim de obter uma estimativa da profundidade de um potencial caixa finito que melhor represente cada átomo. Determinamos qual profundidade de caixa e largura (diâmetro atômico) reproduz as auto-energias do estado fundamental obtidas através do método ab-initio Hartree-Fock com uma base aug-cc-pVQZ. Além disso, variamos a profundidade V0 no intervalo (-0.9 a -0.108 Ha em steps de 0.008) e largura L no intervalo (1.9 a 8.83 Bohr em steps de 0.07) de potenciais caixas (totalizando 10 mil soluções numéricas para obtenção das auto-energias) e a partir destes resultados, propusemos uma função de ajuste da forma: E(V,L) = a.ln(-V L)+b.L (V)1/3 + c , função da profundidade da caixa V0 e da largura da caixa L (diâmetro atômico dos elementos) que apresentou um acordo excelente de R2 = 0.992. Desta forma, pudemos com uma aproximação de tão simples como equação de Schrödinger para apenas um elétron confinado num potencial unidimensional reproduzir o resultado do problema de muitos corpos como um átomo hidrogenóide.
Encenando Ditadores
Authors: Rosell Mariana
Published: July 2024

A partir de meados da década de 1950, a dramaturgia brasileira passou por um processo de politização que buscou trazer para os palcos debates teóricos, políticos e estéticos que fizeram dessa linguagem importante agente da linha de frente de resistência ao regime militar que se instalaria no Brasil a partir do golpe civil-militar de 1964. O objetivo deste trabalho é analisar como duas peças brasileiras escritas em 1968, Papa Highirte (Oduvaldo Vianna Filho) e Dr. Getúlio, sua vida e sua glória (Dias Gomes e Ferreira Gullar), se inserem no debate político e artístico da época por meio da representação crítica de personagens ditadores que provocam a reflexão acerca do papel do autoritarismo, seus aliados e modos de operar na trajetória histórica da América Latina, especialmente no século XX.
“Num Abre Alas que Eu Quero Passar de Ensurdecer”
Authors: Pereira Kivia Mirrana
Published: July 2024

O presente artigo aborda sobre uma das principais festas realizadas pelo Ideal Clube: os bailes carnavalescos na cidade de Manaus entre os anos de 1906 a 1920. O Ideal, espaço-objeto dessa análise, foi uma associação recreativa fundada em 1903 e agregava em seu conjunto de sócios os principais grupos econômicos, políticos e sociais da cidade de Manaus em seu contexto de Belle Époque. Adotamos como metodologia o uso e análises das fontes impressas e periódicas e com isso pudemos perscrutar sobre as vivências dos frequentadores do clube que utilizaram-se das recreações para consolidar suas sociabilidades e visões de mundo através dos valores expressos nas suas festividades. Dessa maneira, os bailes carnavalescos acabaram por acentuar os status do clube como um centro de distinção com suas regras monetárias e recursos simbólicos, formando uma a tradição idealina que servia para favorecer os grupos “aristocráticos” que bailavam sobre os prestígios e diferenças sociais.
Conflito e tensão no mar
Authors: Guedes Giovana , Oliveira Beatriz Anselmo de , Junior Fábio Rogerio Banin , Silva João Gabriel da , Rodrigues Jaime
Published: July 2024

Apresentamos a transcrição integral do manuscrito do diário de bordo do navio Nossa Senhora da Conceição, Princesa de Portugal. O relato acompanha o navio entre 1783 e 1785, partindo de Lisboa, passando por ilhas do Atlântico e do Índico em direção à Índia e terminando, inesperadamente, rumo à Bahia. Disponibilizado on-line no Arquivo Nacional da Torre do Tombo, o documento foi lido e transcrito. Posteriormente, catalogamos sua tripulação e criamos um glossário de termos marítimos encontrados e uma cronologia do desenrolar dos eventos. A análise permitiu o levantamento de questões relevantes, como a hierarquia do navio e a sua relação com as tensões entre os diferentes membros da tripulação. Portanto, a importância do artigo se dá na disponibilização de um rico material para a expansão da história dos homens do mar no século XVIII, em especial frente ao ínfimo desenvolvimento da história marítima no Brasil.
A História da Câmara de Vereadores de Taquari no Século XIX, Rio Grande do Sul
Authors: Schmitt Fernanda , Galarce Machado Neli , Pires Karen , Kreutz Marcos Rogério
Published: July 2024

A fundação e formação política do município de Taquari, Rio Grande do Sul, está ligada, dentre outros fatores, às pretensões da Coroa portuguesa nos séculos XVIII e XIX. Portugal disposto a tomar posse do território conquistado a partir do Tratado de Madrid, estabeleceu um povoado transformado, ainda no século XVIII, em Freguesia, o qual alcançou o status de vila em 1849. A emancipação política da Vila de Taquari propiciou a formação de uma elite local representada na Câmara de Vereadores. O objetivo do artigo é apresentar a história do estabelecimento da Câmara de Vereadores entre os anos de 1849 e 1852. Fez-se uso de bibliografias regionais, das Atas e dos Ofícios da Câmara de Vereadores de Taquari, do período descrito.
Mueda: memória e massacre (1979) e a construção do mito fundacional da Independência de Moçambique (1975)
Authors: Souza Queiroz José Antônio
Published: July 2024

A proposta do artigo é refletir sobre como o filme Mueda: memória e massacre (1979), do diretor Ruy Guerra, colaborou para a construção do Massacre de Mueda (1960) como um dos principais mitos políticos da história recente de Moçambique, demarcando o início da luta anticolonial no país. Baseando-se no conceito de mito na configuração dos imaginários, pretende-se analisar como o Massacre de Mueda foi apropriado pela Frente de Libertação de Moçambique (FRELIMO) e narrado pela história oficial como ponto de inflexão do colonialismo no país, ao incitar a formação de movimentos nacionalistas que culminaram na luta armada e na posterior Independência em 1975. Produzido poucos anos após a Independência, por encomenda do Estado, o filme de Ruy Guerra insere-se no debate político pós-Independência e projeta - através do cinema - o mito de Mueda no imaginário social e político do país.
estadista do Império e da República
Authors: Volpini Micheli Marco , Tammone Natalia
Published: July 2024

O presente artigo tem por objetivo, a partir da exploração bibliográfica especializada, apresentar breve panorama da trajetória de Rui Barbosa, destacando especialmente as nuances de seu pensamento econômico e sua atuação à frente do Ministério da Fazenda. Busca-se, assim, analisar com maior detalhamento a associação entre o pensamento econômico e as práticas de Rui Barbosa na vida pública, tendo em vista, de um lado, sua complexa relação com os princípios liberais da economia; e de outro, a originalidade de suas ideias, que devem ser interpretadas à luz da conjuntura brasileira de então. Nessa esteira, pretende-se expor que, a despeito de seu legado ter sido alvo de inúmeras controvérsias, nomeadamente quanto à crise do Encilhamento, numerosos estudos demonstram que as suas propostas reformistas não estavam descoladas da situação brasileira do momento, porquanto Barbosa almejava solucionar os problemas econômicos do final do Oitocentos a partir de um plano consciente de desenvolvimento econômico e de ampla reforma financeira.
As tradições apocalípticas sobre Jesus de Nazaré e a teologia dos Dois Poderes no céu
Authors: De Paula Gabriel Melo
Published: July 2024

As experiências visionárias típicas da apocalíptica judaica abrem espaço para o questionamento a respeito da noção da unidade estrita de Deus dentro do judaísmo do Segundo Templo, frequentemente descrito como monoteísta. Contudo, as tradições visionárias associadas à figura de Jesus de Nazaré parecem pressupor a existência de uma segunda figura divina, de forma a desafiar nossa compreensão a respeito de uma imagem bastante difundida do monoteísmo judaico durante o Segundo Templo. Essa figura divina secundária foi polemicamente tratada pelos rabinos a partir do século II E.C., que usaram polemicamente o conceito de Dois Poderes no céu. Embora um conceito posterior, ele pode iluminar nossa compreensão a respeito dos inícios do movimento de Jesus e da memória histórica que se formou a partir da figura de Jesus de Nazaré.