bluuebunny/crossref_metadata_2025 huggingface dataset:
Elovanoids and Precursor Free Fatty Acid 34:6 Confer Robust Neuroprotection after Experimental Traumatic Brain Injury
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, New Orleans, LA 70112, Baum Samuel E. , Obenaus Andre ,   Department of Pediatrics, University of California, Irvine, Irvine, CA, 92697, Belayev Ludmila , Bhattacharjee Surjyadipta , Ji Jeff , Giles Brian , Mohiuddin Alina , Bazan Nicolas G. ,   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, New Orleans, LA 70112
Published: January 2024

One-third of the close to 70 million people suffering from traumatic brain injury (TBI) have an increased risk for developing chronic cognitive impairments, including Alzheimer’s-like Dementia (AD). We studied neuroprotection by Elovanoid-34:6 (ELV-N34) and its precursor free-fatty- acid-34:6 (FFA34:6) following TBI in male Sprague-Dawley rats using fluid percussion injury (FPI) or controlled cortical impact (CCI) models. At 1 and 24 hours post-surgery, rats were intranasally administered saline, ELV-N34, or FFA34:6 (only in the CCI model). Rats underwent composite neurological testing to assess sensorimotor integration. On day 14, FPI animals were sacrificed, and MRI and diffuse tensor imaging (DTI) were performed to assess lesion size and white matter connectivity. On day 3, CCI animals were used for multi-omic analysis using 10x Chromium, Illumina Sequencing, and Seurat v4.0.1. Total neurological scores for animals administered ELV-N34 and FFA34:6 were lower than controls, and scores for FFA34:6 treated rats were lower than those of ELV34:6 treated rats (p<0.05). MRI and DTI showed smaller lesions and preserved white matter connectivity in the ELV34:6 group. Single cell analysis with ELV-N34 treatment revealed downregulation of Spp1, Fos, and Gfap genes and upregulation of Trem2 and Pld5 genes. FFA34:6 treatment revealed downregulation of inflammatory genes Spp1, Ccl2, and Vim. These changing gene cluster patterns are implicated in neurodegenerative diseases. We demonstrated that ELV-N34 and FFA34:6 convey behavioral, structural, and genetic neuroprotective bioactivity in experimental TBI.
ELV-N34 or RvD6-isomer Counteracts Damaging Astrocyte Phenotypes Protecting the Brain from Omicron BA.5 Sequelae
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, LA 70122, USA, Bazan Nicolas G. , Calandria Jorgelina , Bhattacharjee Surjyadipta , Bazan Haydee E.P. ,   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, LA 70122, USA, Maness Nicholas J. ,   Tulane National Primate Research Center, Covington, LA, USA
Published: January 2024

Neurodegenerative diseases induce astrocyte phenotypes that trigger inflammation and cell damage. This cell induction also takes place in post-acute neurological syndrome from SARS-CoV-2 infection. We found that the secretome from Omicron BA.5 infected human nasal epithelial or human lung cells induced the activation of human astrocytes to a reactive pro-inflammatory phenotype as defined by nuclear translocation of NF-kB/p65. Remarkably, the secretome from these cells incubated with Elovanoid (ELV)-N34 or Resolvin D6 (RvD6)-isomer (500nM) did not trigger the formation of reactive astrocytes. One of the factors involved is CXCL1, secreted by Omicron BA.5-infected nasal epithelial cells. So, when CXCL1 was administered intranasally to mice along with Interferon type I, the infiltration of fluorescein indicated a permeabilization of the neurovascular unit. Astrocytes are close to this barrier and contribute to restricting the access of damaging molecules to the brain parenchyma. Together, these results point to a specific way of entry of chemokines and cytokines as part of the secretome from infected cells that may play a role in long COVID brain sequelae.
Single Cell Transcriptomics Define Cell Heterogeneity in Limbal/Corneal Cells Relevant to Nerve Regeneration
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, Louisiana 70112, USA, Bazan Haydee E.P. , Ponnath Abhilash , Bhattacharjee Surjyadipta , Gordon William , Bazan Nicolas G.
Published: January 2024

Balanced interplay of cell-type specific transcriptomic regulation is critical for nerve regeneration in the central and peripheral nervous system. As a model, we use the cornea, where we recently discovered the RvD6-isomer and its function as a regulator of nerve regeneration, critical for dry eye in aging. Single-RNA-sequencing (snRNASeq) and spatial transcriptomics were used to interrogate cell populations and gene expression in central cornea/limbus from male, 3-month, C57BL/6 wild-type (WT) and injured mice cornea. Isolated nuclei from cornea/limbus of WT mice (N=12) were processed by 10×Genomics pipeline Cellranger. Central mice corneas were damaged with 2mm trephine, and epithelium and anterior stroma removed with corneal rust ring remover (Algerbrush II). Two days post-injury, corneas were excised, formalin-fixed paraffin-embedded, and 5µm sections prepared for Visium CytAssist mediated probe hybridization, library construction, sequencing, data analysis using Spaceranger, data visualization and cell cluster annotation using Loupe Browser. Cell populations were distinguished by t-distributed stochastic neighbor embedding (t-SNE). RNAscope® assay was used to validate two genes, ALDH3A1 and SPARC.
Single-Cell Multiome Analysis Reveals Neuroprotection by Elovanoids in Experimental Ischemic Stroke
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA 70122, USA, Ji Jeff , Bhattacharjee Surjyadipta , Baum Sam , Belayev Ludmila , Bazan Nicolas G
Published: January 2024

Ischemic stroke results in severe loss of neurological functions, and a large proportion of survivors display the onset of cognitive impairments. Administration of a novel class of very long-chain polyunsaturated fatty acids (VLC-PUFAs) termed elovanoids (ELV-N34) or its VLC-PUFA precursor (C34:6) are protective against both in vitro and in vivo models of uncompensated oxidative stress and ischemic stress. We found that ELV-N34 or C34:6 delivery attenuates sensorimotor deficits after ischemic stroke. Furthermore, we uncovered that ELV and its precursors protect against ischemic damage by modulating inflammatory signaling and increasing the expression of neuroprotective genes. We used 10X Single Cell Multiome (ATAC + Gene Expression) to compare genomic and epigenomic responses in naïve rats and after experimental ischemic treatment. Adult Sprague-Dawley rats underwent 2 hours of middle cerebral artery occlusion (MCAo) via intraluminal suture. Rats received vehicle, ELV-N34, or C34:6 delivered intranasally 1 hour, 1 day, and 2 days after 2 hours of MCAo. Brains were harvested on day 3 from the ipsilesional cortex (penumbra region) and subcortex. Nuclei were isolated and processed according to 10X Genomics Single Cell Multiome protocol. ELV-N34 or C34:6 treatment reduced neurological deficits after MCAo. Joint single-cell analysis revealed increases in microglia and leukocyte abundance as well as a loss of neuronal populations after MCAo. Differential gene expression revealed that ELV or its precursors protected against MCAo through complex mechanisms involving anti- inflammatory signaling and promoted neuroregeneration in microglia, astrocytes, neurons, and other neural cells. ELV/precursors exert their bioactivity by modulating conversion to neuroprotective cell phenotypes in neurodegenerative diseases such as stroke or Alzheimer's disease.
Combinatorial Treatment by NPD1 Plus RvD1 Elicits Neurobehavioral Recovery and Increases Homeostatic Gene Expression after Experimental Ischemic Stroke
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, LA 70122, USA, Mohiuddin Alina , Ji Jeff , Belayev Ludmila , Bazan Nicolas G.
Published: January 2024

Stroke is the second leading cause of death worldwide and a high proportion of those who survive stroke develop severe cognitive impairments. Current therapies, tissue plasminogen activator (tPA) and thrombectomy, are ineffective for most patients affected by stroke. This research explores mechanisms and examines the potential of combined Neuroprotectin D1 (NPD1) and Resolvin D1 (RvD1) treatment in ischemic stroke.
Spatially Resolved Transcriptomics Reveal Changing Landscape of Survival Molecular Signatures in Age-related Macular Degeneration
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, LA 70122, USA, Moore Warner , Bhattacharjee Surjyadipta , Kautzmann Marie-Audrey I. , Bazan Nicolas G.
Published: January 2024

We study AMD because it accumulates debris beneath the retinal pigment epithelium (RPE), forming so-called “Drusen” analogous to senile plaques of Alzheimer's, including the accumulation of amyloid-beta peptide. We found a decrease in components of the pathway leading to the formation of the pro-homeostatic mediators, the elovanoids (ELVs), specifically in the rod photoreceptors of retinas from donors with age-related macular degeneration (AMD). Retinas were formalin-fixed paraffin-embedded (FFPE), and 5µm microtome sectioning, H&E staining, 10X Genomics Visium CytAssist, and Illumina Sequencing were followed by analysis with Spaceranger and Seurat bioinformatics. By mapping the transcriptome of the human retina, we found gene expression differences in the normal retinas compared to the AMD retinas, both in the rod and cone areas. Transferrin (TF), APOE, and ABCA4 genes were decreased in AMD. Our data have uncovered gene clusters and transcriptomic signatures in regulatory pathways of cell survival in rods and cones in AMD.
Role of Aging, Genetics after Exposure to Airborne Particulate matter and High Temperatures on a Mouse Model of Alzheimer's Disease
Authors:   Geriatrics Research, Education and Clinical Center, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, 10468, Pasinetti Giulio Maria , Iban-Arias Ruth , Dias Portela Ariana Soares , Masieri Sibilla , Yang Eun-Jeong
Published: January 2024

Background: Elevated temperatures are usually accompanied by corresponding increases in concentrations of air pollutants increasing mortality or morbidity, which may feasibly be attributed to an interaction between the two factors. High temperatures and high levels of air pollution are increasingly linked to cognitive decline in individuals over 65 years. We hypothesize that the combined exposures to particulate matter (PM2.5) and heat stress (HS) may alter brain glucose metabolism and gut dysbiosis leading to increased cognitive impairment and accelerated AD phenotype.
Elovanoids Suppress Lipid Peroxidation after Experimental Stroke: An LC-MS-based Untargeted Lipidomics Analysis
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, LA 70122, USA, Van Leeuwen Christopher J. , Perera Rasangi M. , Ji Jeff X. , Belayev Ludmila , Bazan Nicolas G
Published: January 2024

At the onset and progression of neurodegenerative diseases, enhanced reactive oxygen species (ROS) and an overall uncompensated oxidative stress environment evolve. Oxidized phospholipids (OxPLs) cause detrimental perturbations to synaptic membranes and other parts of the nervous system. We tested if the lipid mediators Elovanoids (ELVs) that exert neuroprotective signaling also counteract lipid peroxidation using an experimental ischemic stroke model. Male Sprague-Dawley rats after 2 hours of middle cerebral artery occlusion (MCAo) were used. ELV-N34 was administered intranasally at 1 hour, 24 hours and 48 hours after, and rats were sacrificed on day 3; the brains were removed and sampled into the right and left hemispheres and the cortex, subcortex. Untargeted lipidomics were performed using a Waters Xevo G2-XS QTof system under MSE mode, and collected MS/MS spectra for the OxPLs was processed and searched against a reference spectral library by MS-DIAL software. ELV-N34 reduced oxidized phosphatidylcholine (OxPC) and phosphatidylethanolamine (OxPE) molecular species. We suggest that ELVs target lipid peroxidation as part of their neuroprotective bioactivity.
The Effectiveness Of Using Learning Media To Increase Knowledge And Preventive Measures Of Diabetic Foot Ulcers In Patients With Diabetes Mellitus
Authors: Lestari Lestari , Ginting Suriani Br. , Zulfikar Nani , Siregar Siti Hasanah
Published: January 2024

Background : Diabetic foot ulcer is one of the complications of DM's disease. Prevention of diabetic foot ulcers can be done by providing health education to improve the knowledge, attitudes, or actions of patients with diabetes mellitus but it is very necessary to provide a health education in order to be able to understand and able to do it. In fact diabetic ulcer numbers are increasing. It is necessary to increase the method and media delivery of the health education. Objective: The literature of this review aims to be to know the effectiveness of the use of media learning towards increased knowledge and preventive measures of diabetic foot ulcers as well as finding similarities, differences, advantages and disadvantages of the journals in review. Methods: This study uses review literature designs obtained from Google Scholar sources. The key word in this review literature search is the prevention of diabetic foot ulcers with dependent variable use of learning media and independent variables of knowledge and action. Results: Out of 5 studies gained 3 national journals and 2 international journals with the result that health education using the media has a significant influence on knowledge, attitude, and practice.
Hubungan Antara Pola Makan Dengan Hipertensi Pada Lansia Di Desa Risa
Authors: Jannah Nurul
Published: January 2024

The diet that causes hypertension is the diet of older people that consumes sugar, raising, high salt,excessive fatsuch as heavy coconut mmilk, oil,vagetables and other gas-filled friutsand beverange consumed daily, such as coffe.

The study was intended to shed light on the relationship between diet and hypertension in the elderly in the village of Risa.

Research methods used by cross sesctional with sesctional engineering. The sampling used is 40 respondents about the distribution of respondents based on low diet with hypertensive concerns in the village of Risa, low 0 respondents (0.0%). Moderate diet with the incidence of hypertension, 0 respondents (0.0%). High diet with hypertension incident, 3 respondents (9.7%). Lower 4 respondents (66.7%). Diets are current with the incidence of hypertensions being 3 (100%). High diet with the incidence of hypertension, 20 high(64.5%), then lower 2 (33.3%). Moderate diet with incidence of hypertension, 0 respondents (0.0%). High diet with hypertension 8 respondents (25.8%).

Studies obtained no correlation between diet and hypertension in the elderly is p=0.680<0.05. Which mean there’s no link between diet and hypertension in the elderly in Risa village and p=0.680”.

The conclusion for research on the relationship between diet and hypertension in the village of Risa concludes: “there’s no link between diet and hypertension in the elderly in Risa village and p=0.680”.
The Implementation of K3 Culture Towards Employee Productivity
Authors: Umar Risa Bernadip , Tahir G Muhammad , Nuryani Siti , Betan Abu Bakar , Erwhani Indri , Hartono Hartono
Published: January 2024

The implementation of an K3 culture really depends on the employee's level of knowledge, workload and work environment. Workers know about the risks that may occur, but because there is no sanction from the company, workers do not comply with the use of Personal Protective Equipment (PPE) in implementing K3. The aim of this research is to determine the implementation of K3 in the form of employee personal protective equipment in terms of the knowledge, workload and work environment factors of employees at PT. Bahana Prima Nusantara. This research uses a qualitative method that digs deeper into the extent of the implementation of personal protective equipment in the K3 culture on employee productivity, where the number of informants is 5 people. As for the data collection method, it consists of primary data obtained from interviews, while secondary data is obtained from other supporting data. The conclusion from the research results is that workers' lack of knowledge has an impact on employee work productivity, excessive workload can affect employee productivity, and a comfortable and enjoyable work environment will form a productive work culture.
Community Perceptions Regarding the Implementation of the Role of Health Nurses at Program Achievement Levels
Authors: Wuriani Wuriani , Djunaedi Djunaedi , Carolina Dina , Wahyudi Ardi , Lukita Yenni , Sriyanti Febri
Published: January 2024

Nursing services have an important role in the implementation of health services in public hospitals nationally. Success in a hospital depends greatly on the performance and role and function of nurses in providing nursing services. The role of nurses as Care Givers is to provide health services to individuals, families, groups and communities in the form of comprehensive nursing care which includes providing nursing care, providing direct assistance to individuals / patients and families / communities who experience problems with the need for security. Optimizing the role of nurses is very necessary where nurses must carry out their duties. The aim of this research is to determine public perceptions regarding this matter implementation of the role of nurses at the Tamalanrea Community Health Center. The design of this research is a descriptive survey method based on inclusion criteria. This research uses cluster sampling techniques and univariate analysis to analyze the data. The results show that the public has positive perceptions regarding several roles of nurses. Around 67% of the public have a positive perception of the role of nurses as educators. Therefore, it is hoped that nurses can improve their duties and functions as nurses and expand their role as nurses which still need improvements that have not been implemented well.
Sanitation and Enviromental Health in Traditional Snack Food Trader of Elementary School, Buntusu Village, Makassar City
Authors: Serli Serli , Werdyaningsih Endang , Yulis Dian Meiliani , Mustari Sahdan , Atika Zummatul , Kunaryanti Kunaryanti , Yusrianto Yusrianto
Published: January 2024

Many snacks do not meet health requirements and therefore threaten children's health. Most school children's snacks are traditionally processed foods sold by street vendors. The aim of this research is to determine the implementation of hygiene and sanitation among traditional snack food traders in the Buntusu Village Elementary School environment, Makassar City. This research is a descriptive study designed based on a cross sectional approach. The population in this study were all traditional snack food traders in the Buntusu Village Elementary School area, Makassar City. So it can be concluded that the distribution of respondent characteristics includes 73.9% of respondents aged 24-54 years, 52.2% of respondents are male, 47.8% of respondents have worked as traditional snack food traders for 1-10 years, There were 4.3% of respondents with the highest level of education, namely graduating from college, and 8.7% of respondents with the lowest education, namely not attending school. And 52.2% of respondents had good personal hygiene, while the remaining 47.8% of respondents had poor personal hygiene.
Breast Care for Pregnant Women to Increase Mother's Milk Production in the Working Area of the Lotang Salo Health Center
Authors: Parwati Dewi , Hasibuan Evis Ritawani , Ambarawati Eny Retna , Reffita Lea Ingne , Mansur Tri Novianty , Ula Zumrotul
Published: January 2024

Breast care for pregnant women that has been carried out so far is still oriented towards providing counseling or in other words, the emphasis is more on increasing knowledge and not specifically on implementation, nor has an evaluation been carried out on the results of post-counseling knowledge absorption so it is difficult to measure and assess how much application of their knowledge of breast care. This study aims to determine the effect of breast care on increasing breast milk production in Post Partum mothers at the Lotang Salo Sidrap Health Center. The results of the study show that 95% of 20 pregnant women performed breast care in the form of Breast Exercise/Breast Massage, pregnant women who underwent breast care. Her breast milk comes out smoothly at 95%. Results Daily breast milk production on the first day was 10-30 cc/day in 8 people (40%) and 20-40 cc/day was also in 8 people (40%), on the second day breast milk production was 40-60 cc/day in 10 people (50%), while on the third day breast milk production increased to 60-80 cc/day in 15 people (75%). The results of the study also showed that 15 pregnant women who did not take care of their breasts had poor milk production (75%) and 5 people (25%) did not produce breast milk. From the results of this research, it was concluded that pregnant women prefer breast care with breast massage; Breast Care with Breast Exercises/Breast Massage produces smoother milk production; Pregnant women who perform breast care have a significant effect on increasing breast milk production.
Risk Factors for Sexual Violence in Adolescents : Literature Review
Authors: Trilia Trilia , Nambiar Nisha , Said Faridah Mohd
Published: January 2024

Introduction: Every year sexual violence cases increase and become a widely heard issue in the community. The increase in cases that occur requires research that examines what the risk fator affects. The purpose of this study was to analyze scientific articles related to what are the risk factors for sexual violence in adolescents. Material and Methods: The research employed literature review. The literature consists of journals with a travel year from 2018 to 2022. Literature collection was done through Google scholar, Pubmed, and ScienceDirect using the keyword “sexual violence”, “risk factor”, and “teenager”. Results: The results of the literature search 34.927 articles found in the database regarding entered keywords; however 34.917 articles in the last five years were excluded because they were not relevant to the author’s criteria. There were 5 articles that met the inclusion criteria, however only six articles categorized as good quality. Conclusion : Review results show that have any risk factors affecting sexual violence of a teenager, among other things gender, alcohol, age, sexual disorder, family, gadget, environmnet, disability, a poor parental education, economic, lust, religion, dating, and sexual intercourse.
Nurses' Knowledge About Wound Management at Bhayangkara Hospital, Manado, North Sulawesi
Authors: Khair A. Miftahul , Nasela Sitti Johri , Intang Sitti Nur , Djunaedi Djunaedi
Published: January 2024

Problems and complications that arise due to injuries, if they do not receive proper and serious treatment, can result in lifelong disability and this causes lifelong suffering for the client. The aim of the research is to determine the description of nurses' knowledge of emergency management of injured patients at Bhayangkara Hospital, Manado, North Sulawesi. This research design uses a descriptive design, a research design that is structured in such a way that researchers can obtain answers to research questions. Research design refers to the type or kind of research chosen to achieve research objectives, and acts as a tool and guide to achieve these objectives. The research results show that a person's length of work in an organization or agency is not synonymous with high productivity. People with a long period of service do not mean they have a high level of proficiency. The longer someone works, the more skilled and experienced they are in their job.
Diet Therapy and Physical Activity on Blood Sugar Levels in Diabetes Mellitus Patients in the Inpatient Room at Luwuk Banggai Regional Hospital
Authors: Inamah Inamah , Sahalessy Yona , Pannyiwi Rahmat
Published: January 2024

Diabetes mellitus is a degenerative disease that is closely related to diet therapy. Diet Therapy is a description of the types, amount and composition of food a person eats every day. An urban lifestyle with a diet pattern that is excessively high in fat, salt and sugar results in various diseases including diabetes mellitus.

The aim of the research is to determine the effect of diet therapy and physical activity on blood sugar levels in diabetes mellitus patients. This research is a quantitative research using an observational approach with a cross sectional design, namely research by studying the correlation between risk factors and the effects they cause by approaching, observing or collecting data at one time. The results of the statistical analysis test show the chi-square test X2 = 4.022 or at a confidence level (α = 0.05) P-value 0.045. So it can be concluded that there is a significant relationship between physical activity variables and blood sugar levels in diabetes mellitus patients. The Odd Ratio (OR) value = 3.3 (95% CI 0.090 – 1.002) meaning that less physical activity has a risk of developing Type II DM that is 3.3 times greater than those with less diet therapy.
Self Efficacy On Self Care In Coronary Heart Patients
Authors: Koto Yeni , Solehudin Solehudin , Kurniawan Muhamad Okeu
Published: January 2024

Non-communicable diseases are the leading cause of death in the world, one of the non-communicable diseases is coronary heart disease. Self-efficancy in people with heart disease is defined as confidence in the patient's ability to perform physical activity that can be affected by symptoms or complications of cardiovascular disease. Rehospitalization is not only due to the progression of the disease, but can also be caused by indifference to medication and poor self-care. Self-care is the process of maintaining health through practices that promote health, and manage diseases and symptoms. The study aims to improve the relationship between self-efficiency and self-care in coronary heart patients. The research method used in this study includes quantitative research with a sectional coss study design using a chi-square test with a sample of 70 patients suffering from coronary heart disease in the Hospital Cinere Diagram. Based on the results of the chi-square test that has been carried out obtain a p value of 0.007 or & < 0.05 where this indicates that there is a relationship between self-efficiency and self-care. The conclusion is that self-efficancy has a significant relationship with self-care in patients with coronary heart in Hospital Diagram Cinere
Relationship between Workload and Nurses' Performance in the Implementation of Hospital Health Services in Makassar
Authors: Rusli Rusli , Sima Yenny , Sembiring Lisma Natalia Br , Nursinah Andi , Zaenal Zaenal , Mustamin Rini
Published: January 2024

Health care is any effort organized alone or together in an organization to maintain and improve the health of individuals, families, groups and or communities. Documentation in nursing is an important part of the action taken by nurses after performing nursing actions. The records carried out contain reports that are needed to decide on assessment, diagnosis, develop nursing plans, implement and evaluate nursing activities, which have been designed in a structured, valid and able to be accounted for both morally and legally. The purpose of the study was to determine the relationship between workload and nurse performance in the implementation of nursing care. This research is descriptive research. This research took place in the treatment room of Makasar City Hospital. The population in this study were all nurses who served in the treatment room of Makasar City Hospital and the research sample was 35 nurses using the Total Sampling Technique. Data analysis using Univariate and Bivariate analysis using statistical tests with a level of meaning α = 0.05. The statistical test used is Chi- square using the SPSS computer program version 25.0 for windows. The results of the study using the Chi-square statistical test using SPSS on the relationship between workload and the performance of the implementation of nursing care documentation in the treatment room of Makassar City Hospital obtained a p-value = 0.001 or smaller than a = 0.05, then H0 is rejected and Ha is accepted, which means that there is a relationship between workload and the implementation of nursing care documentation.
Intervensi Rolling Massage Dalam Meningkatkan Produksi Asi Pada Ibu Post Partum Di Wilayah Kecamatan Tabungnanen
Authors: Jamilah Sri , Ariani Sri Purwanti , Indria Rekha
Published: January 2024

Postpartum marks the initiation of lactation, and ideally, newborns should be able to breastfeed from their mothers. Postpartum encompasses the period from 2 hours after the delivery of the placenta up to six weeks thereafter. During this duration, mothers undergo numerous changes, both physically and mentally. A common issue that arises during the postpartum period is the irregularity of breast milk supply. The objective of this community service initiative is to provide Back Massage Rolling to postpartum mothers. The method employed involves demonstrating the rolling massage technique to mothers with infants, aiming to facilitate smoother milk production, especially in the rural communities on the outskirts of the Tabunganen sub-district. The approach includes hands-on demonstrations for mothers with infants, teaching them the rolling massage technique to enhance daily breastfeeding experiences. The conclusion drawn is that a significant portion of the community, particularly mothers with infants, can accurately and effectively demonstrate the application of rolling massage in their daily routines.
Correlation between the histopathological findings of gallbladder samples and clinical outcomes within the framework of a hybrid study
Authors: Kasalovic Mladen , Igrutinovic, Gojko , Jakovljevic, Aleksandar , Elek , Zlatan , Dimic, Sasa , Miljkovic, Nikola , Rakic Dalibor
Published: January 2024

Background: This study focuses on the histopathological characteristics of benign and potentially malignant lesions of the gallbladder, with a specific emphasis on the efficacy of cholecystectomy as a secondary preventive measure in specific clinical contexts. The aim is to contribute to the development of improved preventive and therapeutic approaches. Methodology: This research study employed a hybrid approach of retrospective and prospective data analysis on cholecystitis during the year 2023. Various variables were analyzed to explore their associations with clinical outcomes. Results: The study included 63 patients, with no statistically significant differences in age between male and female patients. Analysis of the length, width, and thickness of the gallbladder wall did not reveal statistically significant differences (p > 0.05). Correlation analysis showed weak connections between age and gallbladder characteristics. The average recovery time was 4.46 days, and the duration of hospitalization positively correlated with age (p<0.001). Regression analysis indicated an association between symptoms and age and the duration of hospitalization (p = 0.015, p<0.001). Logistic regression demonstrated an accuracy of 61.9%, with high precision in predicting stays longer than 3 days. Chi-square tests confirmed statistically significant differences in histopathological diagnoses related to comorbidities (p = 0.021). Conclusion: Gender-specific approaches in postoperative treatment of patients with gallbladder issues highlight significant differences in patient characteristics, while the analysis of comorbidities reveals a connection between hypertension and pathological changes in the gallbladder.
Hubungan Dukungan Orang Tua dengan Social Skill pada Anak Speech Delay Usia 3-6 Tahun di Klinik Liliput Jakarta
Authors: Talitha Ula Sabilla Pasya , Soesyasmoro R. Asto
Published: January 2024

Abstract
Background: Speech delay in children is a common problem. A child is said to be late in speaking if his speech ability is below the proper level of development of the child's speech, and this has an impact on the child in developing his social skills (social skills). So it needs to be a serious concern for parents in supporting their children. Objectives: This research aims to determine the relation between parental support and social skill in children with speech delay aged 3-6 years at Liliput Clinic, Jakarta. Methods: This is a quantitative research with a cross-sectional study design and a correlational approach. Total Sampling was used as a data sampling technique for 35 samples. The research instrument used a questionnaire on parental support and social skills. Both data scales are ordinal and analyzed using the Kendall Tau test. Results: Based on the correlation test data analysis, the result is p = 0.006 which means that the p value < 0.05. So it can be concluded that Ha is accepted and Ho is rejected. This indicates that there is a relation between parental support and social skill in children with speech delay. Meanwhile, the correlation coefficient (r) is 0.337 which indicates that the relationship between the two variables is in the weak category and the direction of the correlation is positive. Conclusion: It can be concluded from this research that there is a relation between parental support and social skill in children with speech delay aged 3-6 years at Liliput Clinic, Jakarta.
Keywords: Parental Support, Social Skill, Speech Delay.
1.0.0.20
Pengaruh Progressive Muscle Relaxation terhadap Stres Mahasiswa Baru Jurusan Okupasi Terapi Poltekkes Surakarta
Authors: Nihayaturrohmah Nihayaturrohmah , Kurnia Rina
Published: January 2024

Abstract
Background.High stress levels during the first year of college can make students difficult to adapt and vulnerable to various social and psychological problems, which can decrease the GPA. To assist students in identifying and managing the stress they experience, it is necessary to recommend the application stress management training in educational programs (Chang et al.,2017). One of the stress management exercises that can be done is relaxation, one of the relaxation methods that can be used to reduce student stress levels is Progressive Muscle Relaxation. Objectives. This research was conducted to determine the effect progressive muscle relaxation the stress of new students in the Department of Occupational Therapy, Surakarta Polytechnic. Methods. The research conducted was a quantitative study with a pre-experimental type research design one group pretest-posttest. Student stress was calculated using the DASS instrument DASS 42, with the inclusion criteria of students who get a score of 15-18 on examination using DASS 42, are willing to get 12 interventions, and are not currently getting other interventions when they are sampled. The sample of the study was 30 students, and the sampling technique used purposive sampling.Data analysis used paired t-test technique, using an interval data scale. Result. Based on the characteristics of the research sample: the total number of respondents is 30 respondents. The number of female respondents was higher with 26 respondents. The age of respondents who took part in this study was 17-22 years old. The highest age distribution of respondents was at the age of 18 with a total of 20 respondents. Results pretest DASS 42 average scores 21.37. Resultposttestaverage 14.47. The total difference in the average value pretest and value posttest was 6.63. The results of data analysis using the paired t-test technique, p-value0.000 (p<0.05). Conclusion. These results indicate if the interventionProgressive Muscle Relaxation affects the stress of new students in the Department of Occupational Therapy, Surakarta Polytechnic.
Keywords : Progressive MuscleRelaxation, New Student Stress
Hubungan antara Kesadaran Orang Tua Tentang Perkembangan Bahasa Dengan Kemampuan Bahasa Ekspresif Pada Anak Usia Prasekolah di KB-TK Aisyiyah Al-Amin Surakarta
Authors: Vina Wibowo Devriani , Gunawan Gunawan
Published: January 2024

Abstract
Background: The development of language skills in children is divided into 2, one of which is expressive language skills. An expansive language ability is a person's ability to convey messages verbally or in writing. The development of children can be influenced due to the awareness of the closest people, especially parents. But in reality, there are still many parents who do not have awareness of their role in stimulating children's language from an early age. Awareness consists of 5 aspects including AWAREness namely, Attention, Wakefulness, Architecture, Recall of Knowledge and Emotive. Purpose: The purpose of this study was to determine the relationship between parents' awareness about language development and expressive language skills in preschool-age children in KB-TK Aisyiyah Al-Amin Surakarta. Methods: This research is a quantitative study using a Cross Sectional research design. The sample used was 30 respondents based on the general benchmark of "role of thumb". The sampling technique uses purposive sampling technique. The statistical test used is the Spearman Rank correlation test. Results: Parents' awareness of language development was in the good category of 15 parents (50.0%). Enough for 10 parents (33.3%), and less for 5 parents (16.7%). Expressive language skills in the above category averaged 12 respondents (40.0%), in the average category there were 13 respondents (43.3%) while the remaining 5 respondents (10.0%) were in the below average category. The results of the bivariate analysis obtained that the p value was 0.001 which indicated that the p value was 0.001 <0.05 and the correlation coefficient (r) was 0.560. Conclusion: Parents' awareness of language development is related to expressive language skills in preschool-age children in Aisyiyah Al-Amin Surakarta Kindergarten with moderate correlation strength.
Keywords: Parental awareness, expressive language skills, age preschool.
Pengaruh Terapi Akupunktur Terhadap Glikohemoglobin Darah pada Pasien Obesitas di Pos Kesehatan Lansia Surakarta
Authors: Sumanto Sumanto , Tri Haryanto Joko
Published: January 2024

Abstract
Background: Obesity and overweight are often associated with the risk of type 2 diabetes mellitus. The impact of obesity and overweight is not only one of the factors causing dysfunction of organs such as the heart, blood vessels, nerves and senses of sight and touch to peripheral nerve damage, but also causes a decrease in the quality of human resources, caused by physical and mental disorders to increase health costs.  The incidence of type 2 diabetes mellitus in Indonesia is 10.6 million between the ages of 20 - 79 years out of a total Indonesian population aged 20 - 75 years of 175.1 million. Based on the results of the International Diabetes Federation survey, 2019, Indonesia is ranked 7th in the world with the highest number of diabetes mellitus patients. Objectives: HbA1C examination is an examination that aims to predict the onset of DM disease by knowing the degree of blood glucose metabolism during the last 2-3 months. The International Expert Committee determined the importance of HbA1C examination in screening DM disease diagnosis (American Diabetic Association, 2014). Methods: This study used a quasi-experimental approach with a control group. This quasi-experimental research is a study that manipulates acupuncture therapy treatment in obese and overweight patients. This study involved 1 group, namely the treatment group to find the cause and effect relationship, as well as the amount of contribution between these relationships.  Results: Bivariate analysis of data using paired t test on blood glucose levels of overweight patients amounted to 0.655 with a probability significance level (sig.) p of 0.524. This shows that the sig. p value of 0.524> p 0.05, meaning that acupuncture action in overweight patients has no effect on blood glucose levels. Conclusion: Analysis of Hb.A1c data in overweight patients showed 9.167 and a probability significance value of p=0.000. This shows that acupuncture action in overweight patients has an effect on Hb.A1c levels.
Keywords:  Acupuncture, Uric Acid, Elderly
Analisis Nilai-Nilai Pendidikan Karakter Pada Buku Siswa Kelas IV Tema Indahnya Kebersamaan
Authors: Zuleni Elva , Sri Wulan Dari Nadia
Published: January 2024

Pendidikan karakter sangat diperlukan bagi peserta didik pada jenjang sekolah dalam membentuk watak serta peradaban bangsa yang bermartabat. Kemampuan pendidik dalam mengimplementasi pendidikan karakter dalam pembelajaran sangat penting. . Tujuan penelitian ini yaitu untuk mendeskripsikan: 1. Aspek ketepatan nilai-nilai karakter 2. Aspek penyajian buku ajar 3. Aspek materi buku ajar 4. Aspek bahasa buku ajar. Pada penelitian ini pendekatan yang digunakan adalah pendekatan kualitatif dengan jenis penelitiannya deskriptif. Hasil analisis menunjukan bahwa pada ketepatan nilai-nilai karakter yang ada pada buku guru yaitu nilai peduli dan santun, namun yang ditemukan dalam buku siswa yaitu nilai nasionalis dan nilai gotong royong. Artinya untuk nilai peduli dan santun tidak ditemukan dalam buku. Aspek penyajian buku ajar pada buku sudah baik atau sudah layak untuk digunakan dalam proses pembelajaran, namun untuk contoh-contoh soal dalam buku siswa kurang hanya 50%, seharusnya untuk contoh soal dalam buku ada. Aspek materi buku ajar dalam buku sudah baik atau layak digunakan dalam proses pembelajaran, namun dalam beberapa materi menunjukan bahwa materi yang disajikan sama atau berulang-ulang. Buku siswa kelas IV tema 1 indahnya kebersamaan butuh direvisi dan penulis merekomendasikan nilai karakter yang terdapat pada buku yaitu nilai nasioanlis dan nilai gotong royong. Aspek penyajian buku ajar seharusnya untuk contoh soal dalam buku ada, agar siswa mudah mengerjakan latihan yang ada dibuku siswa. Aspek materi buku ajar seharusnya materi yang disajikan tidak berulang-ulang tapi berbeda agar tingkat pemahaman siswa bertambah. Aspek Bahasa pada buku ajara pada perkembangan emosioanal lebih baik lagi jika ditonjolkan pada buku siswa
Pengembangan Modul Pembelajaran Tematik Terpadu Berbasis Contextual Teaching And Learning Pada Peserta Didik Kelas IV di Sekolah Dasar
Authors: Wahyuni Sisri
Published: January 2024

Penelitian ini dilatar belakangi oleh beberapa permasalahan yaitu belum ada ketersedian modul pembelajaran tematik terpadu berbasis contextual teaching and learning (CTL), guru kurangnya mengaitkan pembelajaran dengan masalah yang ada dalam kehidupan sehari-hari peserta didik, pendidik sudah memberikan buku panduan berupa bahan ajar namun peserta didik kurang tertarik, bahan ajar tersebut tidak banyak gambar, bahan ajar didominasi dengan gambar yang tidak berwarna, dikarenakan kertas yang digunakan hanya kertas koran dan dikemas biasa, Kolom isian latihan terbatas, jadi peserta didik tidak dapat maksimal mengeksporasi jawabannya terhadap latihan-latihan. Penelitian ini bertujuan  untuk mengembangkan dan memvalidkan modul berbasis contextual teaching and learning (CTL). Jenis Penelitian ini adalah penelitian pengembangan R&D (Research and Development) model pengembangan yang dilakukan adalah model 4D yang terdiri dari atas tahap pendefinisian (define), tahap perangcangan (design) tahap pengembangan (developmen), dan tahap penyebarluasan (dissemenate). Hasil penelitian pengembangan modul pembelajaran tematik terpadu berbasis contextual teaching and learning dengan tiga orang validator dosen Universitas Adzkia dan satu guru SD negeri 22 Mata Air dinyatakan sangat valid. Dengan tingkat kevalidan yang diperoleh pada tahap pengembangan modul diperoleh dengan persentase kelayakan design (92,5%) dan bahasa (85,7%) dan materi dari dosen (87,5%) dan materi dari guru (92,5%).dan tingkat pratikalitas modul berbasis contextual teaching and learning (CTL) guru (93,75%) dan kepratikalitas modul berbasis contextual teaching and learning (CTL) lima orang peserta didik adalah (95,30%)dan keefektifitasan dari tiga orang peserta didik(Gicela100%), (Lidya 98%),(fa`izza 98%).Jadi membuktikan bahwa modul berbasis contextual teaching and learning pada pembelajaran tematik terpadu tema 8 subtema 1 dinyatakan sangat valid dan layak digunakan.
Desarrollo de tres poblaciones de nemátodo dorado sobre cinco clones de papa
Authors: Rodriguez Herrera Raul , Gelacio Pérez Ugalde Gelacio , Landeros Flores Jerónimo , Cepeda Siller Melchor
Published: January 2024

Con la finalidad de observar la reproducción de tres poblaciones de nemátodo dorado Globodera rostochiensis (Woll. 1923) Mulvey y Stone 1976, recolectados en los Estados de Nuevo León, Guanajuato y México, sobre los clones de papa 75-07-83, López, Diamante, 75-06-01 y Alpha, se establecio el presente trabajo en 1986, bajo condiciones de invernadero, en la Universidad Autónoma Agraria: Antonio Narro, ubicada en Buenavista. Saltillo, Coahuila.

La prueba se realizó en macetas de donde se inocularon los clones con quistes de G. rostochiensis, a un nivel de 100 quistes/kg de suelo; el diseño estadístico bajo el cual se establecio el experimento fue el de completamente al azar con arreglo factorial.

Se detectó que las poblaciones de nemátodos que más afectan a los clones fueron las provenientes de los Estados de Guanajuato y de Nuevo León: estas dos poblaciones tuvieron un comportamiento muy similar con respecto a las variables evaluadas. A la vez se observó que la inoculación de este nemáto-do afecta el peso de los tubérculos, de las raices y del follaje. El cultivar Diamante fue el que mejor se comportó ante el ataque de las tres poblaciones.
Producción de semilla de dos variedades de zacate banderilla con diferentes densidades de siembra
Authors: González Dominguez Jorge R.
Published: January 2024

El estudio se realizó en Navidad, N.L. en 1985. El objetivo fue estudiar la respuesta en producción de semilla de dos variedades de zacate banderilla Bou-teloua curtipendula (Michx.) Torr. a cinco densidades de siembra. Se usó un arreglo factorial 2x5, con un diseño experimental de bloques completos al azar con cuatro repeticiones. Se registraron datos de rendimiento de semilla (espi-gas) y de los tres componentes del rendimiento: número de culmos por metro lineal de surco, número de espigas por racimo y peso de espiga. Se determinó, además, el peso de 1 000 cariópsides. La variedad AN Selección 75, superó a la variedad Chihuahua 75 en rendimiento de semilla (espigas), número de cul-mos por metro lineal de surco y número de espigas por racimo. La variedad Chihuahua 75 superó a la variedad AN Selección 75, en peso de espiga y peso de 1 000 cariópsides. En ninguna de las variables medidas se encontró efecto de las densidades de siembra.
Proximate Analysis of Maranta Arundinacea L. Flour
Authors: Duay Butch Stephen , De Leon Marilyn , Santos Albert
Published: January 2024

Maranta arundinacea L., also known as arrowroot, are underground rhizomes, or tubers from which arise reed-like, erect stemmed plant. This can be considered as a non-conventional raw material for flour. In Bustos, Bulacan, history tells that arrowroot starch is the primary ingredient of its chief town product which is Minasa, a local biscuit. In the process of extracting starch from the arrowroot, the waste rhizome is collected and grinded as arrowroot flour. This paper seeks to probe the ash content, moisture content, crude fat, crude protein and carbohydrates present on the arrowroot flour. In the proximate analysis it showed that the waste rhizome flour contains 2.03% ash, 8.15% moisture, 0.36% crude fat, 1.86% crude protein and 87.6% carbohydrates.  Based on the result, it implies that the rhizome waste product of the arrowroot starch extraction can be made as a flour and can have a potential of producing products that may increase the value of the production of arrowroot in the town of Bustos in Bulacan.