bluuebunny/crossref_metadata_2025 huggingface dataset:
Amorphous poly-N-vinylcarbazole polymer as a novel matrix for the determination of low molecular weight compounds by MALDI-TOF MS
Authors: Chen Xiu-Ying , Wang Yong-hui , Ren Shu-Yue , Li Shuang , Wang Yu , Qin Kang , Li Sen , Han Dian-Peng , Peng Yuan , Han Tie , Gao Zhi-Xian , Gao Bao-Xiang , Zhou Huan-ying
Published: May 2022

Amorphous, highly salt tolerant and stable polymer PVK as a negative ion mode matrix was successfully achieved for the qualitative and quantitative detection of small molecule compounds by MALDI MS.
Comparing the efficacy of various methods for sulfate radical generation for antibiotics degradation in synthetic wastewater: degradation mechanism, kinetics study, and toxicity assessment
Authors: Behnami Ali , Aghayani Ehsan , Benis Khaled Zoroufchi , Sattari Mohammad , Pourakbar Mojtaba
Published: May 2022

In the present study the aim was to investigate and compare various methods of persulfate activation for amoxicillin degradation.
Microwave-assisted synthesis of Ag/ZnO nanoparticles usingAverrhoa carambolafruit extract as the reducing agent and their application in cotton fabrics with antibacterial and UV-protection properties
Authors: Porrawatkul Paweena , Pimsen Rungnapa , Kuyyogsuy Arnannit , Teppaya Nongyao , Noypha Amnuay , Chanthai Saksit , Nuengmatcha Prawit
Published: May 2022

This is the first timeAverrhoa carambolafruit extract has been used as a reducing agent to synthesize Ag/ZnO composites for coating cotton to develop antibacterial activity and UV protection under domestic microwave irradiation.
Conversion of bio-carbohydrates to 5-hydroxymethylfurfural in three-component deep eutectic solvent
Authors: Zhang Hongtao , Liu Xiao , Han Miaomiao , Zhang Rui
Published: May 2022

The conversion process of fructose and glucose in the three-component DES system. Substrates such as fructose, glucose and sucrose treated with this DES system could convert to HMF in a satisfactory yield and selectivity.
Versatile synthesis of pathogen specific bacterial cell wall building blocks
Authors: Wingen Lukas Martin , Braun Christina , Rausch Marvin , Gross Harald , Schneider Tanja , Menche Dirk
Published: May 2022

A modular three coupling strategy involving a versatile solid phase peptide synthesis enables access to pathogen specific lipid analogs in high yield, revealing high spectroscopic resolution of these key bacterial cell wall building blocks.
Preparation and characterization of attapulgite-supported phase change energy storage materials
Authors: Hu Weijun , Lin Shaohui , Cao Yufeng , Feng Xianshe , Pan Qinmin
Published: May 2022

A facile organic modification method of attapulgite was developedand it's supporting capacity for organic PCMs was significantly enhanced.
In situ fabrication of porous biochar reinforced W18O49 nanocomposite for methylene blue photodegradation
Authors: Li Yi , Chen Wenting , Liu Zhiwei , Cao Dehua , Chen Yu , Thummavichai Kunyapat , Wang Nannan , Zhu Yanqiu
Published: May 2022

Schematic illustration of the proposed reaction mechanism based on the CDAC/W18O49 composite.
Effect of chloride ions on the corrosion behavior of carbon steel in an iron bacteria system
Authors: Xu Ping , Zhao Meihui , Fu Xue , Zhao Chen
Published: May 2022

In the early stage, Cl− destroys the corrosion product film and promotes localized corrosion. In the later stage, a high concentration of Cl− accelerates biofilm growth and densifies the corrosion product layer, thereby inhibiting corrosion.
Correction: Thiophene derivatives as corrosion inhibitors for 2024-T3 aluminum alloy in hydrochloric acid medium
Authors: Arrousse N. , Fernine Y. , Al-Zaqri Nabil , Boshaala Ahmed , Ech-chihbi E. , Salim R. , El Hajjaji F. , Alami Anouar , Touhami M. Ebn , Taleb M.
Published: May 2022

Correction for ‘Thiophene derivatives as corrosion inhibitors for 2024-T3 aluminum alloy in hydrochloric acid medium’ by N. Arrousse et al., RSC Adv., 2022, 12, 10321–10335, https://doi.org/10.1039/D2RA00185C.
Collective motion of self-propelled chemical garden tubes
Authors: Kumar Pawan , Wang Qingpu , Horváth Dezső , Tóth Ágota , Steinbock Oliver
Published: May 2022

In H2O2 solutions, manganese-containing chemical garden tubes can self-propel due to the catalytic production and ejection of oxygen bubbles.
A simple decagram-scale synthesis of an atomically dispersed, hierarchically porous Fe–N–C catalyst for acidic ORR
Authors: Koyuturk Burak , Farber Eliyahu M. , Wagner Friedrich E. , Fellinger Tim-Patrick , Eisenberg David
Published: May 2022

A scalable synthesis of magnesium ion imprinted nitrogen-doped carbon allows for facile preparation of large quantities of Fe–N–C, for large-scale fuel cell research.
Correction: Rational design of microporous polybenzimidazole framework for efficient proton exchange membrane fuel cells
Authors: Harilal  , Bhattacharyya Rama , Shukla Avanish , Chandra Ghosh Prakash , Jana Tushar
Published: May 2022

Correction for ‘Rational design of microporous polybenzimidazole framework for efficient proton exchange membrane fuel cells’ by Harilal et al., J. Mater. Chem. A, 2022, https://doi.org/10.1039/d2ta00734g.
Use of Speech-to-Text Biofeedback in Intervention for Children With Articulation Disorders
Authors: Findley Brooke R. , Gasparyan Diana
Published: May 2022

Purpose:

This study was conducted to explore the effectiveness of speech to text as a form of biofeedback intervention for speech sound production in children with articulation disorders.

Method:

A multiple-baseline across-participants design was used for this study. Speech-to-text biofeedback was implemented with three children aged 7–9 years who demonstrated consonantal articulation errors. Data regarding accuracy of target phoneme production were repeatedly collected across baseline, treatment, and probe phases.

Results:

Based on the preliminary data collected and analyzed during this study, results suggest that speech to text is an effective approach for addressing speech sound production. All three participants demonstrated improvement in the production of their target phonemes. In addition, all of the participants maintained their skills posttreatment.

Conclusions:

The results of this study provide initial support for the use of speech to text for children who demonstrate articulation disorders. Implications for future research and practice based on the results are discussed.
A RoF-FSO communication system using 10Gbit/s polsk 4-PAM downstream signals
Authors: Tian Qing , Shao Yufeng , Wang Anrong , Yang Jie , Wang Zhuang , Yu Ni , Yang Qiming , Yi Linfang , Yuan Jie , Li Yanlin , Chen Peng , Li Chong , Liu Shuanfan , Zuo Renjie
Published: May 2022

In this paper, the performance of a 60 GHz radio over fiber free space optics (RoF-FSO) communication system with 10Gbit/s 4-ary pulse amplitude modulation (4-PAM) polarization shift-keying (Polsk) downlink signal is proposed and designed. In the receiver, the 60GHz millimeter-wave with 4-PAM downstream signals is generated by the beating of two continuous light waves, and the high frequency signal is demodulated by self-mixing zero difference detection method. Meanwhile, the optical spectra, radio frequency (RF) spectrum, eye-diagram are measured, and the transmission performance of the used RoF-FSO system are analyzed.
Sexualität
Authors: Gehn Jana
Published: May 2022

Definitionen, Fakten, Relevantes – die PiD-Essentials fassen die wichtigsten Informationen zum Thema des Heftes knapp und übersichtlich für Sie zusammen.
Erotik, Flirten und Sexualität im Therapieraum
Authors: Richter Sylke
Published: May 2022

Grundsätzlich fällt es Psychotherapeuten leicht, mit ihren Klienten ins Gespräch zu kommen. Alle Themen dürfen sein, alle Gefühle dürfen gefühlt werden. Doch bei den Themen Sexualität, Erotik oder gar Verliebtheit in den Therapeuten kann es vorkommen, dass es ein kurzes Stocken gibt und nach den passenden Worten gesucht werden muss. Zwei Haltungen sollten parallel nebeneinanderstehen dürfen: einerseits das Wohlwollende, Einladende, andererseits das Grenzwahrende.
Perioperative Echokardiografie der rechts- und linksventrikulären Funktion
Authors: Koeppen Michael , Keller Marius
Published: May 2022

Die Echokardiografie erlaubt eine präzise und minimalinvasive Charakterisierung der rechtsventrikulären (RV) und linksventrikulären (LV) Funktion chirurgischer Patientinnen und Patienten.
Eine korrekte Handhabung und ein fundiertes Verständnis der Messungen sind unabdingbar für eine valide echokardiografische Untersuchung. Im folgenden Beitrag werden die gängigsten, aber auch
einige neue Parameter der RV- und LV-Funktion vorgestellt.
Ansätze für eine nachhaltige Bewegungsförderung
Authors: Eckert Katharina , Wollesen Bettina , Reusch Andrea , Peters Stefan , Schaller Andrea
Published: May 2022

Es besteht kein Zweifel daran, dass Bewegung ein wirksames Medikament ist. Das von der Weltgesundheitsorganisation (WHO) empfohlene minimale Aktivitätsniveau erreichen aber längst nicht alle. Um langfristig Menschen zu Bewegung zu motivieren, benötigt es eine Verhaltensänderung. Das Modell der Bewegungsbezogenen Gesundheitskompetenz bildet die Grundlage, um diese Verhaltensänderung in Gang zu bringen.
Pulsatiler Tinnitus nach Covid-19 Erkankung
Authors: Donnerer Corinna , Taxer Bernhard
Published: May 2022

Nach einer Covid-19 Erkrankung vor einem Monat sind bei einem Patienten extreme Schmerzen im Kopf- und Nackenbereich sowie ein sehr störender, pulssynchroner (pulsatiler) Tinnitus (NRS 6–7/10) als Symptome geblieben. In der physiotherapeutischen Befundaufnahme wird klar, dass der Patient nicht physiotherapeutisch weiterbehandelt werden kann, sondern erst weiter von ärztlicher Seite abgeklärt werden muss. Nach dieser Abklärung und Freigabe zur Fortsetzung der Physiotherapie wird ein Behandlungsplan erarbeitet, der vor allem die Stressbewältigung des Patienten in den Mittelpunkt stellt. Gleichzeitig werden unterstützend manualtherapeutische Techniken an der Halswirbelsäule und der Kieferregion sowie Edukationsmaßnahmen eingesetzt. Durch die erfolgreiche Zusammenarbeit zwischen ärztlicher Abklärung, Physiotherapie und Psychotherapie sowie durch die gute Kommunikation mit dem Patienten kann dieser erfolgreich begleitet und eine deutliche Reduktion der Symptome erreicht werden.
Kosmetische Aspekte in der Shuntchirurgie
Authors: Krönung Gerhard
Published: May 2022

Shunts können für den Patienten kosmetisch belastend sein. Oft kann die Belastung gemindert, in einigen Fällen auch beseitigt werden. Ein vertrauensvoller Dialog zwischen den Patienten und beteiligten Ärzten ist genauso entscheidend wie solide shuntchirurgische Expertise.
Die Travenol-Tankniere
Authors: Sander Ullrich
Published: May 2022

Ab 1956 wurde in den USA von der Firma Travenol die abgebildete 100-Liter-Tankniere gebaut (Abb. 1) – zunächst nur für Akutdialysen. Ab 1960, nachdem B. Scribner in Seattle den nach ihm benannten arteriovenösen Shunt erfand, verzeichnete man weltweit einen eklatanten Mangel an Dialyseplätzen. Viele (auch technische) Lösungen waren geeignet, diesem Mangel etwas abzuhelfen – so auch der Travenol-Tank.
DiGAs als Chance begreifen – Digitale Gesundheitsanwendungen
Authors: Köcker Sebastian
Published: May 2022

Die ersten 32 digitalen Gesundheitsanwendungen, kurz DiGAs, sind im Verzeichnis des Bundesinstituts für Arzneimittel und Medizinprodukte aufgenommen. physiopraxis-Themenscout Sebastian Köcker findet, mit Blick auf die Blankoverordnung und die damit einhergehende finanzielle Verantwortung könnten DiGAs auch für Physiotherapeut*innen von Nutzen sein.
Versorgungsqualität in der außerklinischen Beatmung
Authors: Klingshirn Hanna , Schwarz Sarah B.
Published: May 2022

Die außerklinische Beatmung zeigt eine rasante Entwicklung in den letzten 20 Jahren. Die heute vorherrschende Positivdruckbeatmung kann hierbei entweder nicht-invasiv über Gesichtsmasken oder invasiv mittels endotrachealer Intubation oder Trachealkanüle erfolgen. Insbesondere die nicht-invasive Beatmung (noninvasive ventilation = NIV) hat in den letzten Jahren an Bedeutung gewonnen, da sich die positive Evidenz zu einer Vielzahl an Indikationen zur außerklinischen Beatmung zunehmend mehrt. Um bei der stetig steigenden Anzahl an Patient:innen eine hohe Behandlungsqualität zu gewährleisten, wurden spezifische Leitlinien für die unterschiedlichen Patient:innengruppen verfasst und regelmäßig aktualisiert. Hierbei werden die geeigneten Versorgungsstrukturen dieser teils multimorbiden Patient:innenkohorten stark diskutiert, da durch die rasante Entwicklung in der außerklinischen Beatmung Kapazitätsgrenzen der bestehenden Versorgungsstruktur erreicht werden. Diese Entwicklung zeigt, dass es einer kritischen Evaluation der bestehenden Versorgungsstrukturen bedarf, um auf deren Grundlagen und unter Berücksichtigung der nationalen Charakteristika des deutschen Gesundheitssystems eine patient:innenzentrierte, bedarfsgerechte und ressourcenschonende Versorgungsstruktur zu entwickeln.
Förderpreis Nephrologische Pflege 2022
Authors: Schäfer Christian
Published: May 2022

Die Thieme Gruppe schreibt im Jahr 2022 wieder den Förderpreis Nephrologische Pflege aus und stiftet das Preisgeld von 1500 Euro.
Kurse der Nephrologischen WBS-Ulm
Authors: Bundschu Marion
Published: May 2022

Informationen zu den Veranstaltungen finden Sie auf
www.wbs-ulm.de
.
Effects of ion extraction on discharges in gridded ion source
Authors: Yang Y. R. , Fu S. H. , Ding Z. F.
Published: May 2022

Effects of ion extraction on gridded ion source discharge or the coupling between ion extraction and gridded ion source discharge are investigated for the first time by correlating the ratio of the ion impingement current (Ia) to ion beam current (Ib) with the total gray values extracted from images of discharge glows with and without ion extraction. The results indicate that, under equal power and gas pressure, discharges with high and low Ia/Ib values in the presence of ion extraction are, respectively, more intensive and weaker than those without ion extraction. The competing factors behind the coupling between ion extraction and ion source discharge are ion loss and energetic secondary γ-electron injection from the accelerator grid, which weakens and enhances ion source discharge, respectively.
The influence of thermal parameters on the temperature distribution and output parameters of c-Si solar cell under actual test conditions
Authors: Lu Xiaodong , Gao Sheng , Lu Chao , Lu Di , Lun Shuxian
Published: May 2022

The accurate measurement of the output parameters of photovoltaic (PV) cells is a key step in building a PV system. The output parameters of a PV cell under actual test conditions will appear different degrees of the deviation from those under the standard test conditions. In this work, we are primarily concerned with the deviations of the temperature distributions and output parameters of a testing c-Si solar cell caused by the heat transfer process under actual test conditions. The results show that the temperature distributions of c-Si solar cells under actual test conditions will be uneven and obviously deviate from those under the standard test conditions; the heat transfer coefficients at the interfaces between the front surface and environmental air and between the back surface and mental holder have important consequences for the temperature distributions of c-Si solar cells; under the actual test conditions of PV enterprises, the possible deviation range of short-circuit current density, open-circuit voltage, filling factor, and efficiency may be from −17 to 9 µA/cm2, from −11 to 17 mV, from −0.4% to 0.7%, and from −0.4% to 0.7%, respectively.
Tunable ultra-high quality factor graphene absorber based on semicylindrical silica array and distributed Bragg reflector structure
Authors: Liu Jinlai , Tang Shuai , Ren Bin , Song Jie , Jiang Yongyuan
Published: May 2022

We propose a tunable narrowband absorber by utilizing a graphene monolayer placed between a dielectric semicylindrical array and a multilayer silica/silicon distributed Bragg reflector (DBR) structure. The multi-band perfect absorption can be achieved due to the excitation of multiple resonant modes in the absorber, including the guided mode resonance of the dielectric silica array and BR-based guided mode resonance in the DBR structure. The ultra-high quality factor (Q) is mainly attributed to the low external leakage loss of the resonator and the low intrinsic loss of the graphene monolayer. Moreover, the Q-factor of absorption peaks can be tuned by electrically controlling the Fermi energy of graphene. The sensitivity of a spectral wavelength shift for the refractive index change of the resonator is up to 730 nm/RIU, and the figure of merit is 1043. The proposed graphene-based metamaterial offers potential applications for photodetectors, optical modulators, and sensors in the near infrared frequency regime.
In Ukraine, science will need rebuilding postwar; in Russia, its isolation could endure
Authors: Feder Toni
Published: May 2022

The impulse to help Ukrainian scientists is widespread. But balancing sanctions against Russia while keeping open bridges of communication is tricky and controversial.
Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in adolescent rats
Authors: Jadhav Kshitij S. , Bernheim Aurélien P. , Aeschlimann Léa , Kirschmann Guylène , Decosterd Isabelle , Hoffman Alexander F. , Lupica Carl R. , Boutrel Benjamin
Published: May 2022

Significance

Clinical evidence suggests that adolescents engage in dangerous activities despite understanding the risks involved, questioning the theory of decreased top-down control of the immature prefrontal cortex promoting adolescent disinhibited behaviors. In the present study, we report that adolescent rats show a much higher degree of inflexible behavior when making decisions under conflict compared to adults. Unexpectedly, we identified a lower excitability of layer 5 pyramidal neurons in the anterior insular cortex (AIC) of adolescent rats and smaller synaptic glutamatergic inputs to these cells but no difference in layer 5 prefrontal cortex pyramidal neurons. Chemogenetic activation of AIC neurons reduced persistent reward-seeking despite punishment, suggesting that the delayed maturation of the insula may promote inflexible reward-related behaviors in adolescent rats.
Connection between water’s dynamical and structural properties: Insights from ab initio simulations
Authors: Herrero Cecilia , Pauletti Michela , Tocci Gabriele , Iannuzzi Marcella , Joly Laurent
Published: May 2022

Significance

First-principles calculations, which explicitly account for the electronic structure of matter, can shed light on the molecular structure and dynamics of water in its supercooled state. In this work, we use density functional theory, which relies on a functional to describe electronic exchange and correlations, to evaluate which functional best describes the temperature evolution of bulk water transport coefficients. We also assess the validity of the Stokes–Einstein relation for all the functionals in the temperature range studied, and explore the link between structure and dynamics. Based on these results, we show how transport coefficients can be computed from structural descriptors, which require shorter simulation times to converge, and we point toward strategies to develop better functionals.
Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I–deficient and MHC I
+
tumors
Authors: Wolf Natalie K. , Blaj Cristina , Picton Lora K. , Snyder Gail , Zhang Li , Nicolai Christopher J. , Ndubaku Chudi O. , McWhirter Sarah M. , Garcia K. Christopher , Raulet David H.
Published: May 2022

Significance

Immunotherapy provides long-term remissions in numerous types of cancer but is ineffective in most tumors with poor immune cell infiltrates or lacking T cell epitopes or MHC I molecules. Agents that activate the STING protein showed promise in several MHC I
+
and MHC-deficient tumor models in mice, where they induced powerful antitumor CD8
+
T cell and natural killer (NK) cell responses, respectively. They were less effective in numerous other tumor models and yielded mixed results in the clinic in human patients. This report demonstrates strong synergy between a STING agonist and an IL-2 superkine in effectively curing difficult-to-treat MHC-deficient and MHC-positive tumor models in mice by mobilizing T cells and NK cells. This combination therapy shows considerable promise for clinical application.
Gene discovery and virus-induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids in
Euphorbia peplus
Authors: Czechowski Tomasz , Forestier Edith , Swamidatta Sandesh H. , Gilday Alison D. , Cording Amy , Larson Tony R. , Harvey David , Li Yi , He Zhesi , King Andrew J. , Brown Geoffrey D. , Graham Ian A.
Published: May 2022

Significance

Euphorbia peplus
, a member of the
Euphorbia
genus, is rich in jatrophane and ingenane diterpenoids. Using a metabolomics-guided transcriptomic approach to gene candidate identification, we have discovered a short-chain dehydrogenase gene involved in the production of the lathyrane jolkinol E. We have developed a virus-induced gene-silencing method in
E. peplus
that has allowed us to demonstrate the direct relationship between casbene and polycyclic diterpenoids and that jolkinol C acts as a key branch point intermediate in the production of ingenanes and jatrophanes. This work contributes both knowledge and tools for engineering production of bioactive diterpenoids in heterologous host systems, thus enabling their further evaluation and development.
ASIC3, a proton-gated ion channel with preference for polyunsaturated lipids with specific headgroup and tail properties
Authors: Liin Sara I.
Published: May 2022

Commentary highlighting valuable mechanistic insights provided by Klipp and Bankston on ASIC3 regulation by lipids.
Approaching multi-band and broadband high absorption based on one-dimensional layered structures containing monolayer MoS2
Authors: Liu Yang , Wang Zhiyong , Zhou Benyuan , Ming Liu , Deng Lei , Yu Li , Cheng Long
Published: May 2022

MoS2 has attracted considerable attention owing to its unusual and intriguing potential applications in optoelectronic devices. In this study, the absorption properties of a simple one-dimensional (1D) layered structure composed of monolayer MoS2 are analyzed by transfer matrix method. The dielectric permittivity of monolayer MoS2 is employed using the Lorentz model. The influences contributed to the period of the structure and the incident angle are numerically investigated. Our results indicate that a tunable multi-band (broadband) absorber can be achieved by using such a 1D layered structure. A multi-band (broadband) absorption phenomenon can be obtained by increasing the period of the structure. Furthermore, the absorption peaks and broadband absorptance spectra have blue-shifted as the incident angle increases.
Accelerated oxygen evolution kinetics on Ir-doped SrTiO3 perovskite by NH3 plasma treatment
Authors: Deng Li-Li , Ma Xiao-Ping , Lu Man-Ting , He Yi , Fan Rong-Lei , Xin Yu
Published: May 2022

Exploring low-cost and high-performance catalysts for oxygen evolution reaction (OER) remains to be a great challenge. Iridium-based perovskite oxide has large potential in OER because of its intrinsic activity and outstanding physicochemical properties. In this study, iridium-doped strontium titanate (Ir-STO) solution is brushed on a Ti sheet by the traditional method to obtain the Ir-STO/Ti electrodes after being calcined at a high temperature. The microstructure and electrocatalysis properties of the Ir-STO are further modified by a facile and scalable NH3-plasma strategy. In addition to the doping of Ir, the NH3 plasma treatment further results in N-doping into Ir-STO, which enriches active species and causes oxygen vacancies near doped sites. The resulting N, Ir-STO/Ti electrode reveals excellent acidic OER activity with the lowest overpotential of 390 mV at 10 mA/cm2 and the smallest Tafel slope of 140 mV/dec after 10-min plasma treatment. Therefore, the great potential of activated N, Ir-STO/Ti is regarded as a catalyst for the OER, and thus making a new opportunity for developing other perovskite catalysts via NH3 plasma treatment.
Charge self-trapping in two strand biomolecules: Adiabatic polaron approach
Authors: Chevizovich D , Zdravković S , Chizhov A V , Ivić Z
Published: May 2022

We investigate the properties of the excess charge (electron, hole) introduced into a two-strand biomolecule. We consider the possibility that the stable soliton excitation can be formed due to interaction of excess charge with the phonon subsystem. The influence of overlap of the molecular orbitals between adjacent structure elements of the macromolecular chain on the soliton properties is discussed. Special attention is paid to the influence of the overlapping of the molecular orbitals between structure elements placed on the different chains. Using the literature values of the basic energy parameters of the two-chain biomolecular structures, possible types of soliton solutions are discussed.
Prediction of flexoelectricity in BaTiO3 using molecular dynamics simulations
Authors: Zhou Long , Zhang Xu-Long , Cao Yu-Ying , Zheng Fu , Gao Hua , Liu Hong-Fei , Ma Zhi
Published: May 2022

Flexoelectric effect, referring to the strain gradient induced polarization, widely exists in dielectric materials, but its molecular dynamics has not been studied so much so far. In this work, the radial distribution function of BaTiO3 and the phase transition temperatures have been investigated, and the results show that the core-shell potential model is effective and the structure of BaTiO3 is stable in a temperature range of 10 K–150 K. Molecular dynamics simulated hysteresis loops of BaTiO3 show that anisotropy can play an important role in the coercive field. Based on the rational simulation process, the effects of cantilever beam bent angle and fixed length on the polarization are analyzed. It is found that the small bent angle of the curved cantilever beam can give a proportional relationship with a fixed end length and a non-linear relationship is presented when the bent angle is much larger. The prediction of flexoelectric coefficient in BaTiO3 is 18.5 nC/m. This work provides a computational framework for the study of flexoelectric effect by using molecular dynamics.
Exploring Majorana zero modes in iron-based superconductors
Authors: Li Geng , Zhu Shiyu , Fan Peng , Cao Lu , Gao Hong-Jun
Published: May 2022

Majorana zero modes (MZMs) are Majorana-fermion-like quasiparticles existing in crystals or hybrid platforms with topologically non-trivial electronic structures. They obey non-Abelian braiding statistics and are considered promising to realize topological quantum computing. Discovery of MZM in the vortices of the iron-based superconductors (IBSs) has recently fueled the Majorana research in a way which not only removes the material barrier requiring construction of complicated hybrid artificial structures, but also enables observation of pure MZMs under higher temperatures. So far, MZMs have been observed in iron-based superconductors including FeTe0.55Se0.45, (Li0.84Fe0.16)OHFeSe, CaKFe4As4, and LiFeAs. In this topical review, we present an overview of the recent STM studies on the MZMs in IBSs. We start with the observation of MZMs in the vortices in FeTe0.55Se0.45 and discuss the pros and cons of FeTe0.55Se0.45 compared with other platforms. We then review the following up discovery of MZMs in vortices of CaKFe4As4, impurity-assisted vortices of LiFeAs, and quantum anomalous vortices in FeTe0.55Se0.45, illustrating the pathway of the developments of MZM research in IBSs. Finally, we give perspective on future experimental works in this field.
The qualitative behavior for 𝛼-harmonic maps from a surface with boundary into a sphere
Authors: Li Jiayu , Zhu Chaona , Zhu Miaomiao
Published: May 2022

Let

u
α

u_\alpha

be a sequence of smooth

α
\alpha

-harmonic maps from a compact Riemann surface

M
M

with boundary

∂
M

\partial M

to a compact Riemannian manifold

N
N

with free boundary

u
α

(
∂
M
)

u_\alpha (\partial M)

on a supporting submanifold

Γ
\Gamma

of

N
N

and with uniformly bounded

α
\alpha

-energy. If the target manifold

N
N

is a sphere

S

K
−
1

S^{K-1}

, we show that there is no energy loss for such a sequence of maps during the blow-up process as

α
↘
1

\alpha \searrow 1

. Moreover, the image of the weak limit map and bubbles is a connect set. Also, the case of Dirichlet boundary is considered.
The variability of juvenile dispersal in an opportunistic raptor
Authors: García-Macía Jorge , López-Poveda Gabriel , De La Puente Javier , Bermejo-Bermejo Ana , Galán Manuel , Álvarez Ernesto , Morollón Sara , Urios Vicente
Published: May 2022

The juvenile dispersal of raptors is a crucial stage that stretches from parental independence to the establishment of the first breeding area. Between 2012 and 2020, 44 juvenile red kites Milvus milvus from the Spanish breeding population were tagged using GPS telemetry to study their dispersal. Juveniles left the parental breeding area at the end of their first summer and performed wandering movements throughout the Iberian Peninsula, returning to the parental breeding area the following year, repeating the same pattern until they settled in their first breeding area. We analyzed the mean distance from the nest, the maximum reached distances, and the traveled distances (daily and hourly) during the first 2 years of dispersal and compared them. Despite the high individual variability, variables describing the dispersal movements of juveniles showed a decreasing trend during the second dispersal year: 80% of individuals reached a shorter maximum distance in the second year, 70% decreased their mean distance to the nest, 65% decreased their hourly traveled distances, and 50% decreased their daily traveled distances. On the other hand, the red kites usually combined wandering movements with the establishment of temporary settlement areas (TSA). The average duration of settlement in the TSAs was 75 ± 40 days (up to 182 days) and was located at 182 ± 168 km from the nest. In those areas, juveniles used 781.0 ± 1895.0 km2 (KDE 95%). Some of the TSAs were used by several individuals, which suggests that these areas might be good targets for conservation in future management plans
The way to a man’s heart is through his stomach? A unique case report of transient constrictive pericarditis secondary to infarction of herniated omentum following bariatric surgery
Authors: Singh Suhasini , Rowe M. , Hopkins G. , Dahiya A.
Published: May 2022

Background

Intrapericardial diaphragmatic hernias are a rare form of diaphragmatic hernia. The presentation is usually acute due to trauma or from iatrogenic causes. In some instances however, these patients can present years later. We describe an unusual case of transient constrictive pericarditis associated with herniation of omentum through a diaphgragmatic hernia extending into the pericardial space, which infarcted following recent bariatric surgery. A multi-disciplinary approach was required with surgical correction of the diaphragmatic defect and removal of omentum from the pericardial space.

Case summary

A 38-year-old gentleman with a history of a remote abdominal stab wound and recent laparoscopic gastric sleeve procedure presented with sharp central chest pain radiating to the shoulder. Chest imaging [echocardiography, computed tomography (CT), and cardiac magnetic resonance imaging (MRI)] revealed the presence of an intrapericardial diaphragmatic hernia and herniation of devascularized omentum into the pericardial space. Surgery was undertaken to remove the pericardial omentum. Echocardiography and cardiac MRI revealed changes of pericardial constriction which resolved with anti-inflammatories.

Discussion

A multi-disciplinary approach was required in this case with surgical correction of the diaphragmatic defect and removal of omentum from the pericardial space. Multi-modal imaging proved essential in the diagnosis of this rare condition, aiding in timely diagnosis, ongoing management decisions, and for assessing therapeutic response.
C7 WEARABLE CARDIOVERTER – DEFIBRILLATOR IN PATIENTS WITH HIGH RISK OF SUDDEN CARDIAC DEATH: IS IT USEFUL A PATIENT SELECTION?
Authors: Bolognesi M , Rossi L , Biagi A , Coccia M , Sticozzi C , Comastri G , Aschieri D
Published: May 2022

Background

The wearable cardioverter defibrillator (WCD) is considered in patients with increased risk of sudden cardiac death (SDC), in which implanted cardiac defibrillator (ICD) is temporary not definitively indicated. A few registry confirmed efficacy and safety of WCD and left ventricular ejection fraction recovery (LEVS)after wearing time.

Methods

We considered in our study 40 consecutively patients that used WCD in Piacenza and Castel San Giovanni Cardiology Department from August 2017 to September 2021 with recent acute myocardial infarction, newly diagnosed cardiomyopathy, primary arrhythmias syndrome awaiting diagnostic completation. They were followed by remore monitoring. The primary outcome were: the need of ICD implantation or not indication to ICD at the of the wearing time, We analyzed clinical variables related to primary outcome.

Results

Out of 40 patients, average age 66 years, average LEVS media 29%±12,5,88% were males, 32% suffered from diabetes mellitus, 35% renal failure, 55% acute and chronic heart failure, 10% previous ischemic stroke, 17% atrial fibrillation (AF), 12% cardiac arrest (ACC) after STEMI onset, 20% ventricular tachicardia (VT). 27% of these patients took amiodarone,92% beta blockers and 82% ACEi.The average wearing time of WCD was 51 days and 22,96 hours dailyAt the end of this period 48% of patients didn‘t receive ICD implantation for increasing LEVS.We evaluated clinical variables related to primary outcome with Chi Square test and Student’s t test.There weren’t significant difference regarding primary outcome between ischemic disease and other cardiophaties. The presence of AF, previous stroke, renal failure, hypertension, diabetes mellitus was more but not significant in ICD group. No significant age difference(66.8±14.1 vs 66.3±11.8, p = 0,6) neither FEVS (29.4±11.6 vs 29.5±12.7, p = 0,8) was in patients that received ICD versus not received .The clinical variables related to primary outcome only were: ACC after STEMI onset and amiodarone therapy.

Conclusions

In our study of patients with WCD, the percentage of LEVS increase is consistent with European registries. A few clinical variables may be related to ICD indication. Further studies can be useful to identify patients who need more of WCD for a lack of LEVS improvement.
C24 TWIDDLER SYNDROME AND HEART FAILURE: INTEGRATION OF REMOTE MONITORING AND CARDIOLOGY TELECONSULTATION FOR OPTIMAL MANAGEMENT
Authors: Gatto M , Dominici T , Rinaldi M , Rinaldi D , Percoco F , Tung M , Pontiroli C , Persi A , Ciccaglioni L , Kol A
Published: May 2022

The prevalence of heart failure in the population and the COVID pandemic have rendered increasingly necessary the integration of remote monitoring with cardiology teleconsultation. A patient with dilated cardimiopathy was subjected to ICD implantation (Boston Scientific Perciva DR) with remote monitoring (LatitudeTM). One month after implant, remote monitoring recorded an increase in the HeartLogicTM heart failure index, a decrease of right ventricular and atrial sensing, contextually to fluctuations of the impedance values of the two leads (Fig. 1). The patient reported having performed shoulder’s rehabilitation therapy with probable manipulation of the ICD pocket. Chest X–ray showed dislocation of both leads with distal end of right atrial catheter in superior vena cava and distal end of right ventricular catheter in right atrium (Fig. 2A) and kinking of proximal segments (Fig. 2B), a picture compatible with diagnosis of Twiddler‘s syndrome. Implant revision confirmed lead kinking in the subcutaneous pocket (Fig. 3A). The atrial catheter, given the amount of tissue deposited at its distal end (Fig.3B) which prevented its active fixation, was replaced. Following discharge, an increase in the HeartLogicTM Heart Failure Index was detected. The outpatient visit showed the presence of pleural effusion and medical therapy was therefore optimized. In order to avoid frequent ambulatory visits to the patient, a cardiology teleconsultation was planned, which enabled to verify the clinical benefit of therapy’s variation. Remote device monitoring confirmed HeartLogicTM Heart Failure Index normalization. In conclusion, the integration of remote monitoring with cardiology teleconsultation, enables to timely detect device malfunctions and prevent episodes of heart failure, avoiding further hospitalizations. This integration is even more useful and necessary in geographically disadvantaged areas, strengthening the link between the territory and the hospital, improving patients compliance and therapeutic adherence and thus allowing a progressive improvement of the symptoms and quality of life of heart failure patients.
C59 HEART RATE AT DISCHARGE AS INDEPENDENT LONG–TERM PREDICTOR OF ALL–CAUSE MORTALITY IN PATIENTS WITH ACS: INSIGHTS FROM THE APULIA PONTE ACS STUDY
Authors: Lisi F , Locuratolo N , Rutigliano D , Campanella C , Mancini L , Parisi G , De Gennaro L , Bonfantino V , Potenza A , Sasanelli P , Scicchitano P , Barletta A , Caldarola P
Published: May 2022

Background

Heart rate is able to impact on the prognosis if patients with cardiovascular diseases. The aim of this study was to evaluate the impact of heart rate at discharge of patients with ACS and/or coronary revascularization on long–term follow–up

Methods

This was a subanalysis of the PONTE ACS study. The PONTE ACS study is a prospective, longitudinal, cohort study which enrolled patients who were discharged from HUB centres of ASL BARI after coronary revascularization and/or ACS. They underwent clinical evaluation at 30 days, 3, 6 and 1 year–follow–up. The data were collected after including the data in the electronic medical record of the PONTE ACS study. Anthropometric, clinical and pharmacological parameters, instrumental and laboratory examinations were included. Data were computed in order to evaluate the major determinants of all–cause mortality at one–year follow–up.

Results

We finally enrolled 2476 patients (77.4% male, mean age: 67.2±12.0 years). Pharmacological treatments were optimized during the follow–up visits. Heart rate at discharge was 65.5 ± 11.3 bpm. At univariate regression analysis, age, systolic and diastolic arterial pressure, body mass index, smoke habit, diabetes, hypertension, high–density lipoprotein and total cholesterol, creatinine, haemoglobin, fasting glycemia, left ventricle ejection fraction, heart rate, use of ACEi/sartans, statins, dual/triple anti–thrombotics were all related to all–cause mortality. Nevertheless, at multivariate Cox regression analysis, age (β coefficient: 0.07117 ± 0.01942, p = 0.0002), history of hypertension (1.4823 ± 0.7476, p = 0.0474), and heart rate (0.04409 ± 0.01278, p = 0.0006) remained related to the primary endpoint.

Conclusions

Heart rate confirmed to act as a long–term predictor of all–cause death in patients with ACS.
C77 EFFECT OF SACUBITRIL/VALSARTAN ON BOTH METABOLIC PARAMETER AND INSULIN RESISTANCE IN NON OBESE NON DIABETIC PATIENTS WITH HEART FAILURE
Authors: Giofrè F , Ventura M , Sacchetta L , Arturi F , Clausi C , Pelle M , Zaffina I , Lucà S , Sciacqua A , De Rosa F , Arturi F , Cloro C
Published: May 2022

Background

Sacubitril/Valsartan has been shown to improve mortality and reduce hospitalizations in patients with heart failure with reduced ejection fraction (HFrEF). Moreover Sacubitril/Valsartan showed a significantly reduction in the HbA1c in diabetic patients. The effect of Sacubitril/Valsartan on metabolic parameter and insulin resistence in both, non obese and non diabetic patients, have not been previously described.

Aim

We evaluated the effects of the Sacubitril/Valsartan on both glycaemic and metabolic parameter, on HOMA–IR and on echocardiographic parameters in patients with HFrEF.

Methods

A total of 59 non obese and non diabetic patients with a diagnosis of HFrEF (EF < 35%) have been enrolled. All the patients underwent a complete anthropometrical evaluation, laboratory determinations (including fasting glucose, fasting insulin, HbA1c) and echocardiogram evaluation. Data analysis was made after 24 weeks of treatment. The insulin resistance has been assessed by HOMA–IR.

Results

Data analysis demostrated a significant reduction in fasting plasma glucose (111.4 + 11.5 vs 106 + 10 mg/dl, P = 0.03), fasting plasma insulin (13.6 + 5.9 vs 10.5 + 4.4 µUI/ml), HbA1c value (6.14 + 0.5% vs 5.9 + 0.3%, P < 0.01) and insulin resistance (HOMA–IR, 3.74 + 2.2 vs 2.7 + 2.1, P = 0.03). The echocardiogram evaluation showed a significant reduction of the end–diastolic left ventricular volume (168 + 44 vs 150 + 38 ml, P < 0.05), a no significant reduction of the end–systolic left ventricular volume (98 + 26 vs 88 + 22 ml, P = 0.07), a significant reduction of E/e1 ratio and an average 7.8% increase in ejection fraction (EF), from a mean baseline of 32.3 + 2.4 to 40.1 + 3.8% (P < 0.0001). No differences in interventricular septal (IVS) thickness, posterior wall (PW) thickness, A–wave, E–wave and E/A ratio have been observed. No differences in anthropometrical parameters (weight, body mass index, waist circumference) and blood pressure were observed.

Conclusions

Our data, even if preliminary, seem to indicate that sacubitril/valsartan might enhance glycaemic control and improve insulin resistance in non obese/non diabetic patients with HFrEF. Also, our data confirm that sacubitril/valsartan treatment is able to improve ejection fraction in HFrEF patients.
P14 PROCEDURAL SAFETY, SHORT AND LONG–TERM FOLLOW UP AFTER PACEMAKER IMPLANTATION IN NONAGENARIANS
Authors: Meynet I , Tricomi L , Ferraro A , Maggio R , Mazza A , Ceci R , Minniti D , Varbella F
Published: May 2022

Background

Permanent cardiac stimulation is increasingly necessary in very old patients, due to the augmented life expectancy. This raise concerns in physicians, patients and caregivers, because pacemaker (PM) implantation can be perceived as too invasive for frail patients with significant comorbidities. The aim of the present study is to provide data about peri–operative complications, short and long–term survival and their predictors in this specific setting.

Materials and Methods

All consecutive patients aged ≥ 90 years undergoing pacemaker implantation in our Centre from 2008 to 2020 were enrolled in the registry. Their baseline and follow up data were recorded in a specific database.

Results

Among the 2437 patients undergoing PM implantation in a 13–year period, 153 were nonagenarians (6.3%). Mean age was 92.7 ± 2.3 years. Most of the patients (66.7%) received a ventricular single chamber PM. High–degree atrio–ventricular block was the first indication for implant (59.5%), followed by sick sinus syndrome or atrial fibrillation with slow ventricular response (30.1%). 15.7% patients needed temporary pacing at presentation. 4 patients (2.6%) experienced acute complications: 3 pneumothorax, 1 ventricular lead displacement with need of repositioning. Mean follow up duration was 2.5 ± 2.0 years. 117 patients (78.5%) died during the follow up. Death occurred after a mean of 2.47 years after pacemaker implantation (range 1 – 3272 days). Survival rates were 70.0%, 35.3% and 10.0% at 1, 3 and 5 years respectively. No pacemaker–related long–term complication was recorded during the follow up. 2 patients underwent generator replacement due to battery end of life. Chronic kidney insufficiency (p = 0.030) and congestive heart failure (p = 0.021) but not age were predictors of precocious mortality (within 1 month). Age at implant and longer length of hospital stay before PM implantation were predictors of long–term death (p = 0.001 and p = 0.043 respectively).
P42 ASCENDING AORTIC DISEASE: IS CURRENT GENERAL PERCEPTION UPDATED TO CURRENT GUIDELINES ??
Authors: Totaro P , Sciortino A , Preda Z , Pelenghi S
Published: May 2022

Backgroud

Thoracic aorta diseases represent a frequent cause of hospitalization and up to 15% of workload of a modern Cardiac Surgery centre. To allow for an accurate monitoring of such activity a dedicated thoracic aorta diseases clinic was launched in January 2019 at our Division. Clinic was open for all new referrals (both by general pratictioner and different specialities clinic) as well as for follow–up of operated on patients. Here we report our analysis of new referrals during past 30 months.

Materials and Metods

237 overall patients were seen at clinic. 68 patients (29%) were new referrals; 23 patients (10%) were preoperative follow up and 145 (61%) were postoperative follow up. New referrals were divided in urgent referral (42 pts 62%) and scheduled referral (26 patients 38%). Out of 168 follow up, 22 (12%) were requested as urgent follow up. Majority of urgent new referral were from general pratictioner (21 pts 50%).

Results

Only 5 patients (2 urgent referral) had surgical indication at time of clinic assessment, according current guidelines. 23 patients (6 urgent referral) were in the so–called grey zone and required close follow–up). 40 patients (34 urgent referral) had no significant aortic diseases to require neither urgent specialist consultation or close follow–up. Out of 181 postoperative follow up, 12 patients required surgical re–intervention none of these were referred with matter of urgency. Despite 56% of new referral did not have recent CT scan evaluation, majority of new referral clearly showed moderate aortic dilatation especially in urgent referral (Fig 1). When considering indexed–dilatation, proportion of patient with moderate dilation raised even more (Fig 2).

Conclusions

Current perception of clinical severity of thoracic aorta diseases is still sub–optimal. Majority of patients are indeed referred as a matter of urgency despite non–significant aortic ectasia. On other hands, potentially dangerous situation are underestimated by the general practitioner and/or medical specialist. An accurate territorial policy of sensitization and updating about these pathologies is therefore essential to try to reduce the risks of acute aortic syndromes in our country.