bluuebunny/crossref_metadata_2025 huggingface dataset:
A Likely Detection of a Two-planet System in a Low-magnification Microlensing Event
Authors: Suzuki D. , Bennett D. P. , Udalski A. , Bond I. A. , Sumi T. , Han C. , Kim Ho-il. , Abe F. , Asakura Y. , Barry R. K. , Bhattacharya A. , Donachie M. , Freeman M. , Fukui A. , Hirao Y. , Itow Y. , Koshimoto N. , Li M. C. A. , Ling C. H. , Masuda K. , Matsubara Y. , Muraki Y. , Nagakane M. , Onishi K. , Oyokawa H. , Ranc C. , Rattenbury N. J. , Saito To. , Sharan A. , Sullivan D. J. , Tristram P. J. , Yonehara A. ,   (the MOA Collaboration), Poleski R. , Mróz P. , Skowron J. , Szymański M. K. , Soszyński I. , Kozłowski S. , Pietrukowicz P. , Wyrzykowski Ł. , Ulaczyk K. ,   (the OGLE Collaboration)
Published: June 2018

We report on the analysis of a microlensing event, OGLE-2014-BLG-1722, that showed two distinct short-term anomalies. The best-fit model to the observed light curves shows that the two anomalies are explained with two planetary mass ratio companions to the primary lens. Although a binary-source model is also able to explain the second anomaly, it is marginally ruled out by 3.1σ. The two-planet model indicates that the first anomaly was caused by planet “b” with a mass ratio of

and projected separation in units of the Einstein radius, s = 0.753 ± 0.004. The second anomaly reveals planet “c” with a mass ratio of

with Δχ
2 ∼ 170 compared to the single-planet model. Its separation has two degenerated solutions: the separation of planet c is s
2 = 0.84 ± 0.03 and 1.37 ± 0.04 for the close and wide models, respectively. Unfortunately, this event does not show clear finite-source and microlensing parallax effects; thus, we estimated the physical parameters of the lens system from Bayesian analysis. This gives the masses of planets b and c as

and

, respectively, and they orbit a late-type star with a mass of

located at

from us. The projected distances between the host and planets are

for planet b and

and

for the close and wide models of planet c. If the two-planet model is true, then this is the third multiple-planet system detected using the microlensing method and the first multiple-planet system detected in low-magnification events, which are dominant in the microlensing survey data. The occurrence rate of multiple cold gas giant systems is estimated using the two such detections and a simple extrapolation of the survey sensitivity of the 6 yr MOA microlensing survey combined with the 4 yr μFUN detection efficiency. It is estimated that 6% ± 2% of stars host two cold giant planets.
Andromeda’s Parachute: A Bright Quadruply Lensed Quasar at z = 2.377
Authors: Rubin Kate H. R. , O’Meara John M. , Cooksey Kathy L. , Matuszewski Mateusz , Rizzi Luca , Doppmann Greg , Kwok Shui , Martin D. Christopher , Moore Anna M. , Morrissey Patrick , Neill James D.
Published: June 2018

We present Keck Cosmic Web Imager spectroscopy of the four putative images of the lensed quasar candidate J014710+463040 recently discovered by Berghea et al. The data verify the source as a quadruply lensed, broad absorption-line quasar having

. We detect intervening absorption in the Fe ii
λλ2586, 2600, Mg ii
λλ2796, 2803, and/or C iv
λλ1548, 1550 transitions in eight foreground systems, three of which have redshifts consistent with the photometric-redshift estimate reported for the lensing galaxy (z
L ≈ 0.57). The source images probe these absorbers over transverse physical scales of ≈0.3–22 kpc, permitting assessment of the variation in metal-line equivalent width

as a function of sight-line separation. We measure differences in

of <40% across most of the sight-line pairs subtending 8–22 kpc, suggestive of a high degree of spatial coherence for the Mg ii-absorbing material.

varies by >50% over the same scales across the majority of sight-line pairs, while C iv absorption exhibits a wide range in

differences of ≈5%–80% within transverse distances of ≲3 kpc. These spatial variations are consistent with those measured in intervening absorbers detected toward lensed quasars drawn from the literature, in which

and

vary by ≤20% in 35 ± 7% and 47 ± 6% of sight lines separated by <10 kpc, respectively. J014710+463040 is one of only a handful of z > 2 quadruply lensed systems for which all four source images are very bright (r = 15.4–17.7 mag) and are easily separated in ground-based seeing conditions. As such, it is an ideal candidate for higher-resolution spectroscopy probing the spatial variation in the kinematic structure and physical state of intervening absorbers.
Resolving the Nuclear Obscuring Disk in the Compton-thick Seyfert Galaxy NGC 5643 with ALMA
Authors: Alonso-Herrero A. , Pereira-Santaella M. , García-Burillo S. , Davies R. I. , Combes F. , Asmus D. , Bunker A. , Díaz-Santos T. , Gandhi P. , González-Martín O. , Hernán-Caballero A. , Hicks E. , Hönig S. , Labiano A. , Levenson N. A. , Packham C. , Almeida C. Ramos , Ricci C. , Rigopoulou D. , Rosario D. , Sani E. , Ward M. J.
Published: June 2018

We present ALMA Band 6 12CO(2–1) line and rest-frame 232 GHz continuum observations of the nearby Compton-thick Seyfert galaxy NGC 5643 with angular resolutions 0.″11–0.″26 (9–21 pc). The CO(2–1) integrated line map reveals emission from the nuclear and circumnuclear region with a two-arm nuclear spiral extending ∼10″ on each side. The circumnuclear CO(2–1) kinematics can be fitted with a rotating disk, although there are regions with large residual velocities and/or velocity dispersions. The CO(2–1) line profiles of these regions show two different velocity components. One is ascribed to the circular component and the other to the interaction of the AGN outflow, as traced by the [O iii]λ5007 Å emission, with molecular gas in the disk a few hundred parsecs from the AGN. On nuclear scales, we detected an inclined CO(2–1) disk (diameter 26 pc, FWHM) oriented almost in a north–south direction. The CO(2–1) nuclear kinematics can be fitted with a rotating disk that appears to be tilted with respect to the large-scale disk. There are strong non-circular motions in the central 0.″2–0.″3 with velocities of up to 110 km s−1. In the absence of a nuclear bar, these motions could be explained as radial outflows in the nuclear disk. We estimate a total molecular gas mass for the nuclear disk of M(H2) = 1.1 × 107
M
⊙ and an H2 column density toward the location of the AGN of N(H2) ∼ 5 × 1023 cm−2, for a standard CO-to-H2 conversion factor. We interpret this nuclear molecular gas disk as the obscuring torus of NGC 5643 as well as the collimating structure of the ionization cone.
Can Flare Loops Contribute to the White-light Emission of Stellar Superflares?
Authors: Heinzel P. , Shibata K.
Published: June 2018

Since the discovery of stellar superflares by the Kepler satellite, these extremely energetic events have been studied in analogy to solar flares. Their white-light (WL) continuum emission has been interpreted as being produced by heated ribbons. In this paper, we compute the WL emission from overlying flare loops depending on their density and temperature and show that, under conditions expected during superflares, the continuum brightening due to extended loop arcades can significantly contribute to stellar flux detected by Kepler. This requires electron densities in the loops of 1012−1013 cm−3 or higher. We show that such densities, exceeding those typically present in solar-flare loops, can be reached on M-dwarf and solar-type superflare stars with large starspots and much stronger magnetic fields. Quite importantly, the WL radiation of loops is not very sensitive to their temperature and thus both cool as well as hot loops may contribute. We show that the WL intensity emergent from optically thin loops is lower than the blackbody radiation from flare ribbons, but the contribution of loops to total stellar flux can be quite important due to their significant emitting areas. This new scenario for interpreting superflare emission suggests that the observed WL flux is due to a mixture of the ribbon and loop radiation and can be even loop-dominated during the gradual phase of superflares.
High-temperature Ionization-induced Synthesis of Biologically Relevant Molecules in the Protosolar Nebula
Authors: Bekaert David V. , Derenne Sylvie , Tissandier Laurent , Marrocchi Yves , Charnoz Sebastien , Anquetil Christelle , Marty Bernard
Published: June 2018

Biologically relevant molecules (hereafter biomolecules) have been commonly observed in extraterrestrial samples, but the mechanisms accounting for their synthesis in space are not well understood. While electron-driven production of organic solids from gas mixtures reminiscent of the photosphere of the protosolar nebula (PSN; i.e., dominated by CO–N2–H2) successfully reproduced key specific features of the chondritic insoluble organic matter (e.g., elementary and isotopic signatures of chondritic noble gases), the molecular diversity of organic materials has never been investigated. Here, we report that a large range of biomolecules detected in meteorites and comets can be synthesized under conditions typical of the irradiated gas phase of the PSN at temperatures = 800 K. Our results suggest that organic materials—including biomolecules—produced within the photosphere would have been widely dispersed in the protoplanetary disk through turbulent diffusion, providing a mechanism for the distribution of organic meteoritic precursors prior to any thermal/photoprocessing and subsequent modification by secondary parent body processes. Using a numerical model of dust transport in a turbulent disk, we propose that organic materials produced in the photosphere of the disk would likely be associated with small dust particles, which are coupled to the motion of gas within the disk and therefore preferentially lofted into the upper layers of the disk where organosynthesis occurs.
An Extremely Low Mid-infrared Extinction Law toward the Galactic Center and 4% Distance Precision to 55 Classical Cepheids
Authors: Chen Xiaodian , Wang Shu , Deng Licai , de Grijs Richard
Published: June 2018

Distances and extinction values are usually degenerate. To refine the distance to the general Galactic Center region, a carefully determined extinction law (taking into account the prevailing systematic errors) is urgently needed. We collected data for 55 classical Cepheids projected toward the Galactic Center region to derive the near- to mid-infrared extinction law using three different approaches. The relative extinction values obtained are

,

,

, and

. We also calculated the corresponding systematic errors. Compared with previous work, we report an extremely low and steep mid-infrared extinction law. Using a seven-passband “optimal distance” method, we improve the mean distance precision to our sample of 55 Cepheids to 4%. Based on four confirmed Galactic Center Cepheids, a solar Galactocentric distance of R
0 = 8.10 ± 0.19 ± 0.22 kpc is determined, featuring an uncertainty that is close to the limiting distance accuracy (2.8%) for Galactic Center Cepheids.
SOLIS IV. Hydrocarbons in the OMC-2 FIR4 Region, a Probe of Energetic Particle Irradiation of the Region∗
Authors: Favre C. , Ceccarelli C. , López-Sepulcre A. , Fontani F. , Neri R. , Manigand S. , Kama M. , Caselli P. , Al-Edhari A. Jaber , Kahane C. , Alves F. , Balucani N. , Bianchi E. , Caux E. , Codella C. , Dulieu F. , Pineda J. E. , Sims I. R. , Theulé P.
Published: June 2018

We report new interferometric images of cyclopropenylidene, c-C3H2, toward the young protocluster OMC-2 FIR 4. The observations were performed at 82 and 85 GHz with the NOrthern Extended Millimeter Array (NOEMA) as part of the project Seeds Of Life In Space (SOLIS). In addition, IRAM-30 m data observations were used to investigate the physical structure of OMC-2 FIR 4. We find that the c-C3H2 gas emits from the same region where previous SOLIS observations showed bright HC5N emission. From a non-LTE analysis of the IRAM-30 m data, the c-C3H2 gas has an average temperature of ∼40 K, a H2 density of ∼3 × 105 cm−3, and a c-C3H2 abundance relative to H2 of (7 ± 1) × 10−12. In addition, the NOEMA observations provide no sign of significant c-C3H2 excitation temperature gradients across the region (about 3–4 beams), with T
ex in the range 8 ± 3 up to 16 ± 7 K. We thus infer that our observations are inconsistent with a physical interaction of the OMC-2 FIR 4 envelope with the outflow arising from OMC-2 FIR 3, as claimed by previous studies. The comparison of the measured c-C3H2 abundance with the predictions from an astrochemical PDR model indicates that OMC-2 FIR 4 is irradiated by an FUV field ∼1000 times larger than the interstellar one, and by a flux of ionizing particles ∼4000 times larger than the canonical value of 1 × 10−17 s−1 from the Galaxy cosmic rays, which is consistent with our previous HC5N observations. This provides an important and independent confirmation of other studies that one, or more, source inside the OMC-2 FIR 4 region emits energetic (≥10 MeV) particles.
Gradual Streamer Expansions and the Relationship between Blobs and Inflows
Authors: Wang Y.-M. , Hess P.
Published: June 2018

Coronal helmet streamers show a continual tendency to expand outward and pinch off, giving rise to flux ropes that are observed in white light as “blobs” propagating outward along the heliospheric current/plasma sheet. The blobs form within the r ∼ 2–6 R
⊙ heliocentric range of the Large Angle and Spectrometric Coronagraph (LASCO) C2 instrument, but the expected inward-moving counterparts are often not detected. Here we show that the height of blob formation varies as a function of the underlying photospheric field, with the helmet streamer loops expanding to greater heights when active regions (ARs) emerge underneath them. When the pinch-offs occur at r ∼ 3–4 R
⊙, diverging inward/outward tracks sometimes appear in height–time maps constructed from LASCO C2 running-difference images. When the underlying photospheric field is weak, the blobs form closer to the inner edge of the C2 field of view and only the outward tracks are clearly visible. Conversely, when the emergence of large ARs leads to a strengthening of the outer coronal field and an increase in the total white-light radiance (as during late 2014), the expanding helmet-streamer loops pinch off beyond r ∼ 4 R
⊙, triggering strong inflow streams whose outgoing counterparts are usually very faint. We deduce that the visibility of the blobs and inflows depends on the amount of material that the diverging components sweep up within the 2–6 R
⊙ field of view. We also note that the rate of blob production tends to increase when a helmet streamer is “activated” by underlying flux emergence.
β-decay Rates for Exotic Nuclei and r-process Nucleosynthesis up to Thorium and Uranium
Authors: Suzuki Toshio , Shibagaki Shota , Yoshida Takashi , Kajino Toshitaka , Otsuka Takaharu
Published: June 2018

Beta-decay rates for exotic nuclei with neutron magic number of N = 126 relevant to r-process nucleosynthesis are studied up to Z = 78 by shell-model calculations. The half-lives for the waiting-point nuclei obtained, which are short compared to a standard finite-range-droplet model, are used to study r-process nucleosynthesis in core-collapse supernova (CCSN) explosions and binary neutron star mergers. The element abundances are obtained up to the third peak as well as beyond the peak region up to thorium and uranium. The position of the third peak is found to be shifted toward a higher mass region in both CCSN explosions and neutron star mergers. We find that thorium and uranium elements are produced more with the shorter shell-model half-lives and their abundances come close to the observed values in CCSN explosions. In the case of binary neutron star mergers, thorium and uranium are produced consistently with the observed values independent of the half-lives.
PoMiN: A Post-Minkowskian N-body Solver
Authors: Feng Justin , Baumann Mark , Hall Bryton , Doss Joel , Spencer Lucas , Matzner Richard
Published: June 2018

In this paper, we introduce

, a lightweight N-body code based on the post-Minkowskian N-body Hamiltonian of Ledvinka et al., which includes general relativistic effects up to first order in Newton’s constant G, and all orders in the speed of light c.

is written in

and uses a fourth-order Runge–Kutta integration scheme.

has also been written to handle an arbitrary number of particles (both massive and massless), with a computational complexity that scales as O(N
2). We describe the methods we used to simplify and organize the Hamiltonian, and the tests we performed (convergence, conservation, and analytical comparison tests) to validate the code.
Exploring the Variability of the Flat-spectrum Radio Source 1633+382. II. Physical Properties
Authors: Algaba Juan-Carlos , Lee Sang-Sung , Rani Bindu , Kim Dae-Won , Kino Motoki , Hodgson Jeffrey , Zhao Guang-Yao , Byun Do-Young , Gurwell Mark , Kang Sin-Cheol , Kim Jae-Young , Kim Jeong-Sook , Kim Soon-Wook , Park Jong-Ho , Trippe Sascha , Wajima Kiyoaki
Published: June 2018

The flat-spectrum radio quasar 1633+382 (4C 38.41) showed a significant increase of its radio flux density during the period 2012 March–2015 August, which correlates with γ-ray flaring activity. Multi-frequency simultaneous very long baseline interferometry (VLBI) observations were conducted as part of the interferometric monitoring of gamma-ray bright active galactic nuclei (iMOGABA) program and supplemented with additional radio monitoring observations with the OVRO 40 m telescope, the Boston University VLBI program, and the Submillimeter Array. The epochs of the maxima for the two largest γ-ray flares coincide with the ejection of two respective new VLBI components. Analysis of the spectral energy distribution indicates a higher turnover frequency after the flaring events. The evolution of the flare in the turnover frequency-turnover flux density plane probes the adiabatic losses in agreement with the shock-in-jet model. The derived synchrotron self-absorption magnetic fields, of the order of 0.1 mG, do not seem to change dramatically during the flares, and are much weaker, by a factor 104, than the estimated equipartition magnetic fields, indicating that the source of the flare may be associated with a particle-dominated emitting region.
The Correlated Variations of
Narrow Absorption Lines and Quasar Continuum
Authors: Chen Zhi-Fu , Pang Ting-Ting , He Bing , Huang Yong
Published: June 2018

We assemble 207 variable quasars from the Sloan Digital Sky Survey, all with at least 3 observations, to analyze C iv narrow absorption doublets, and obtain 328 C iv narrow absorption line systems. We find that 19 out of 328 C iv narrow absorption line systems were changed by

on timescales from 15.9 to 1477 days at rest-frame. Among the 19 obviously variable C iv systems, we find that (1) 14 systems have relative velocities

and 4 systems have

, where c is the speed of light; (2) 13 systems are accompanied by other variable C iv systems; (3) 9 systems were changed continuously during multiple observations; and (4) 1 system with

16,862 km s−1 was enhanced by

in 0.67 day at rest-frame. The variations of absorption lines are inversely correlated with the changes in the ionizing continuum. We also find that large variations of C iv narrow absorption lines are form differently over a short timescale.
FITspec: A New Algorithm for the Automated Fit of Synthetic Stellar Spectra for OB Stars
Authors: Fierro-Santillán Celia R. , Zsargó Janos , Klapp Jaime , Díaz-Azuara Santiago A. , Arrieta Anabel , Arias Lorena , Sigalotti Leonardo Di G.
Published: June 2018

In this paper we describe the FITspec code, a data mining tool for the automatic fitting of synthetic stellar spectra. The program uses a database of 27,000 cmfgen models of stellar atmospheres arranged in a six-dimensional (6D) space, where each dimension corresponds to one model parameter. From these models a library of 2,835,000 synthetic spectra were generated covering the ultraviolet, optical, and infrared regions of the electromagnetic spectrum. Using FITspec we adjust the effective temperature and the surface gravity. From the 6D array we also get the luminosity, the metallicity, and three parameters for the stellar wind: the terminal velocity (

), the β exponent of the velocity law, and the clumping filling factor (F
cl). Finally, the projected rotational velocity (

) can be obtained from the library of stellar spectra. Validation of the algorithm was performed by analyzing the spectra of a sample of eight O-type stars taken from the iacob spectroscopic survey of Northern Galactic OB stars. The spectral lines used for the adjustment of the analyzed stars are reproduced with good accuracy. In particular, the effective temperatures calculated with the FITspec are in good agreement with those derived from spectral type and other calibrations for the same stars. The stellar luminosities and projected rotational velocities are also in good agreement with previous quantitative spectroscopic analyses in the literature. An important advantage of FITspec over traditional codes is that the time required for spectral analyses is reduced from months to a few hours.
The Gaia–WISE Extragalactic Astrometric Catalog
Authors: Paine Jennie , Darling Jeremy , Truebenbach Alexandra
Published: June 2018

The Gaia mission has detected a large number of active galactic nuclei (AGNs) and galaxies, but these objects must be identified among the thousandfold more numerous stars. Extant astrometric AGN catalogs do not have the uniform sky coverage required to detect and characterize the all-sky, low-multipole proper motion signals produced by the barycenter motion, gravitational waves, and cosmological effects. To remedy this, we present an all-sky sample of 567,721 AGNs in Gaia Data Release 1, selected using WISE two-color criteria. The catalog has fairly uniform sky coverage beyond the Galactic plane, with a mean density of 12.8 AGNs per square degree. The objects have magnitudes ranging from G = 8.8 down to Gaia’s magnitude limit, G = 20.7. The catalog is approximately 50% complete but suffers from low stellar contamination, roughly 0.2%. We predict that the end-of-mission Gaia proper motions for this catalog will enable detection of the secular aberration drift to high significance (23σ) and will place an upper limit on the anisotropy of the Hubble expansion of about 2%.
Small-scale Magnetic Flux Emergence in the Quiet Sun
Authors: Moreno-Insertis F. , Martinez-Sykora J. , Hansteen V. H. , Muñoz D.
Published: June 2018

Small bipolar magnetic features are observed to appear in the interior of individual granules in the quiet Sun, signaling the emergence of tiny magnetic loops from the solar interior. We study the origin of those features as part of the magnetoconvection process in the top layers of the convection zone. Two quiet-Sun magnetoconvection models, calculated with the radiation-magnetohydrodynamic (MHD) Bifrost code and with domain stretching from the top layers of the convection zone to the corona, are analyzed. Using 3D visualization as well as a posteriori spectral synthesis of Stokes parameters, we detect the repeated emergence of small magnetic elements in the interior of granules, as in the observations. Additionally, we identify the formation of organized horizontal magnetic sheets covering whole granules. Our approach is twofold, calculating statistical properties of the system, like joint probability density functions (JPDFs), and pursuing individual events via visualization tools. We conclude that the small magnetic loops surfacing within individual granules in the observations may originate from sites at or near the downflows in the granular and mesogranular levels, probably in the first 1 or 1.5 Mm below the surface. We also document the creation of granule-covering magnetic sheet-like structures through the sideways expansion of a small subphotospheric magnetic concentration picked up and pulled out of the interior by a nascent granule. The sheet-like structures that we found in the models may match the recent observations of Centeno et al.
Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: A pilot study
Authors: Tatsukawa Yumiko , Tsuge Masataka , Kawakami Yoshiiku , Hiyama Yuichi , Murakami Eisuke , Kurihara Mio , Nomura Motonobu , Tsushima Ken , Uchida Takuro , Nakahara Takashi , Miki Daiki , Kawaoka Tomokazu , Abe-Chayama Hiromi , Imamura Michio , Aikata Hiroshi , Ochi Hidenori , Hayes C Nelson , Kawakami Hiroiku , Chayama Kazuaki
Published: June 2018

Background

Although pegylated interferon (PEG-IFN) and nucleotide/nucleoside analogue (NA) combination therapy is considered to be optimal for accelerating serum hepatitis B surface antigen (HBsAg) reduction, the effect is limited, and the best approach to PEG-IFN treatment for chronic hepatitis B patients during long-term NA therapy has yet to be determined.

Methods

A total of 21 hepatitis B e antigen-negative chronic hepatitis B patients whose HBV DNA levels were suppressed to undetectable levels by NA therapy were administrated PEG-IFN-α2a for 48 weeks (sequential therapy: 10, add-on therapy: 11). Factors associated with HBsAg reduction by PEG-IFN therapy were analysed.

Results

During PEG-IFN treatment, HBsAg levels were reduced by 0.48 log IU/ml. More than 1 log IU/ml of HBsAg reduction was observed in eight patients (sequential therapy: six, add-on therapy: two), and one patient with sequential therapy achieved HBsAg loss. By univariate analysis, sequential therapy was marginally associated with more than 1 log IU/ml HBsAg reduction during PEG-IFN treatment ( P=0.060). After PEG-IFN treatment, only five patients, including the patient with HBsAg loss, achieved more than 0.5 log IU/ml of HBsAg reduction by 1 year after PEG-IFN treatment. By univariate analysis, sequential therapy was significantly associated with HBsAg reduction after PEG-IFN treatment ( P=0.012). In addition, alanine aminotransferase elevation during PEG-IFN therapy and lower serum interleukin-8 level at the end of PEG-IFN treatment were also significantly associated with HBsAg reduction by 1 year after PEG-IFN treatment ( P=0.038, P=0.044, respectively).

Conclusions

Sequential therapy may be superior to addon therapy in reducing HBsAg levels during long-term NA therapy in chronic hepatitis B patients.
Monophasic Disease Course in Systemic Lupus Erythematosus
Authors: Tselios Konstantinos , Gladman Dafna D. , Touma Zahi , Su Jiandong , Anderson Nicole , Urowitz Murray B.
Published: June 2018

Objective.

Disease course in systemic lupus erythematosus (SLE) is primarily relapsing-remitting. Long quiescent and chronically active patterns are less frequent. We recently described an atypical “monophasic” course in a small number of patients. The aim of the present study was to assess the prevalence and characteristics of such patients in a defined SLE cohort.

Methods.

The inception patients of the University of Toronto Lupus Clinic (enrolled within 18 mos of diagnosis) were investigated. No time interval > 18 months was allowed between consecutive visits. A monophasic course was defined as Systemic Lupus Erythematosus Disease Activity Index 2000 = 0 (serology excluded), achieved within 5 years since enrollment and maintained for ≥ 10 years. Descriptive statistics were used.

Results.

Of 267 inception patients, 27 (10.1%) achieved prolonged clinical remission (≥ 10 yrs) and 20 (7.5%) sustained remission for the entire followup (18 yrs on average). Twelve patients were receiving no maintenance treatment 10 years after achieving remission. Clinical manifestations at diagnosis (apart from skin and musculoskeletal involvement) included 25% in each of central nervous system involvement and lupus nephritis (LN). Half the patients were serologically active. Ten years after achieving remission, two-thirds of the patients had discontinued glucocorticosteroids; the remaining were treated with 5 mg/day on average. Seven patients relapsed after 10 years, 4 with arthritis, 2 LN, and 1 catastrophic antiphospholipid syndrome.

Conclusion.

A monophasic disease course was observed in 7.5% in this inception cohort. Patients sustained remission for 18 years on average, eventually without medications. Further study of such patients may provide unique pathophysiologic insights for SLE.
Nueva propuesta sobre la simbología de la diadema del tesoro de Ébora
Authors: Gómez Peña Álvaro
Published: June 2018

En el presente estudio se realiza una nueva interpretación sobre el significado de las piezas que componen la zona central de la diadema del tesoro de Ébora. En concreto se defiende que el conjunto está formado por las representaciones de un altar con forma de piel de toro, una asherah, una massebah y una figura antropomorfa que podría tratarse de una representación del dios Bes o de un héroe/divinidad naciendo de la roca. Dichos elementos, especialmente los tres primeros, pueden encontrarse en varios santuarios de tradición fenicio-púnica dentro de la Península Ibérica, la misma identidad que podría otorgársele a la diadema de Ébora. Con esta propuesta se pretende generar una hipótesis simbólicamente más homogénea que las que han ofrecido anteriores publicaciones sobre esta pieza.
La villa romana de Los Villaricos (Mula, Murcia): un gran centro productor de aceite en la Hispania Tarraconense
Authors: González Fernández Rafael , Fernández Matallana Francisco , Zapata Parra José Antonio
Published: June 2018

Los trabajos realizados en la villa romana de Los Villaricos (Mula, Murcia) muestran un establecimiento rural en el que se han identificado muchos de los elementos propios de las instalaciones agropecuarias del mundo romano. Ya han sido dadas a conocer la pars urbana así como una zona aneja que se interpretó como un torcularium. En los últimos años, nuestra atención ha estado centrada en una zona algo alejada de estas instalaciones comentadas, en la que se ha documentado un gran edificio de planta rectangular con una superficie de casi 700 m2 dedicado a la producción de aceite. Se trata de una de las almazaras más grandes de la Península Ibérica y en ella hemos podido identificar todas las partes propias de un torcularium dedicado a la producción de aceite. El edificio tiene una sala de recepción que a la vez pudo funcionar como cella olearia; un tabulatum, una sala de molienda con dos molinos en posición primaria; una sala de prensado con seis prensas, dividida en dos estancias, una, a cota inferior, para contener los contrapesos y otra para los lapides o fora y areae; por último, una sala de decantación en la que se han documentado lacus y una serie de dolia adosadas al muro junto a los desagües de las prensas. Se ha establecido su abandono en torno al siglo V d. C.
La desarticulación del callejero hispanorromano: cambios en la infraestructura viaria y de saneamiento entre los siglos II y VII d. C.
Authors: Ruiz-Bueno Manuel D.
Published: June 2018

La transformación de la civitas clásica en la ciudad tardoantigua fue un proceso de larga duración al que no permaneció ajeno el callejero. El análisis crítico de las fuentes disponibles, especialmente aquellas de carácter arqueológico, nos ha permitido analizar la evolución de la red viaria y de saneamiento hispanorromana entre los siglos II y VII d. C. La necesidad de examinar dicho proceso a escala peninsular, superando el ámbito puramente local, nos ha llevado a realizar un estudio en el que hemos tratado dinámicas tan variadas como la privatización parcial o total de determinadas calles; la ocultación de los primitivos enlosados; la subida de los niveles de circulación, y la inutilización de la red de saneamiento. Frente a la visión tradicional, creemos que la desarticulación del callejero hispanorromano no fue un proceso ajeno a las autoridades, sino que éstas tuvieron un papel destacado.
Una nueva estampilla sobre ánfora púnico-ebusitana hallada en ses Païsses d’Artà (Mallorca): Nueva luz sobre una distintiva forma ebusitana de estampillado
Authors: Torres Joan Ramon , Zamora López José Á.
Published: June 2018

Se presenta el hallazgo, en el poblado talayótico mallorquín de ses Païsses d’Artá, de un fragmento de ánfora púnica de fabricación ebusitana con estampilla. El estudio conjunto de la estampilla y del contexto y tipología de su soporte permite poner el nuevo testimonio en relación con otros sellos anfóricos occidentales y analizarlos en su marco histórico (a situar en torno a la destrucción de Cartago en el 146 a. C.), avanzando en la comprensión del origen y función de estos particulares procedimientos.
Los togados y estatuas vestidas de Barcino
Authors: Claveria Montserrat
Published: June 2018

En este artículo se analizan en detalle las estatuas vestidas y los togados de Barcino conservados hasta la actualidad. El objetivo es obtener una visión de conjunto de estas producciones, que las sitúe al nivel de conocimiento que se posee desde hace tiempo sobre otras producciones barcinonenses, como los retratos o la epigrafía. Además, se pretenden aclarar las controversias cronológicas publicadas hasta el momento sobre una parte de este material. En total se tratan 16 piezas, de las que 10 son togados, una viste túnica, 2 representan a estatuas femeninas según el Schulterbausch-typus y 3 más corresponden a restos de estatuas diversas: una mano derecha, un plinto con un par de calcei y un fragmento de túnica o chitón. El estudio iconográfico y estilístico de estas piezas en relación con el contexto histórico en el que se realizaron y la consideración de su material pétreo, en su mayor parte de gres de Montjuïc, permite obtener conclusiones acerca de la producción y el uso de la escultura en Barcino. Se constata la utilización de estas estatuas durante el siglo I d. C. y la perduración en ellas de modelos triunvirales durante el transcurso del período julio-claudio, sobre todo en las representaciones destinadas al contexto funerario. Se determinan creaciones locales para adaptar los modelos foráneos al entorno de exposición de esculturas concretas, pero en general se aprecia un elevado respeto al lenguaje iconográfico metropolitano, que fue recibido a través de corrientes itálicas y del sureste de la Galia. El elevado alcance de estas influencias sobre las producciones barcinonenses determina el arraigo a la tradición de sus artesanos y el de los comitentes a los códigos establecidos para expresar mensajes de prestigio y autorrepresentación.
El equinoccio en el ritual ibérico. El santuario de La Malladeta (La Vila Joiosa, Alicante)
Authors: Esteban César , Espinosa Ruiz Antonio
Published: June 2018

Presentamos un estudio arqueoastronómico del yacimiento arqueológico de La Malladeta (La Vila Joiosa, Alicante), santuario ibérico y posteriormente romano altoimperial que se utilizó entre los siglos IV a. C. y I d. C. situado en la cima de un promontorio costero. El seguimiento fotográfico de los ortos solares desde la cima del santuario en fechas singulares de la trayectoria anual del Sol indican que el islote de Benidorm pudo haberse utilizado como marcador preciso de los equinoccios o, más probablemente, del día mitad entre solsticios. En esta última fecha, la salida del Sol se produce de forma muy llamativa sobre la ladera sur del islote. Varios de los pocos muros que quedan en la cima del promontorio, correspondientes a la zona nuclear del santuario, donde se llevaron a cabo rituales con fuego, se encuentran alineados hacia el islote. Por otra parte, el orto solar en el solsticio de verano se observa justo en el extremo de la ladera sur del Morro de Toix y cerca de la mole del Peñón de Ifach, lo que podría haberse utilizado como marcador de dicho momento del año. Resulta sugerente que la línea trazada entre La Malladeta y el orto del solsticio de verano coincide con el talud norte del cerro donde estuvo la ciudad íbera de Álon, de donde partían sus vías principales de comunicación y donde estuvo, con toda probabilidad, el foro en época altoimperial romana.
Les juristes face à la globalisation
Authors: Alemany Macario
Published: June 2018

L’article vise à promouvoir une réflexion sur les obligations morales des juristes, en tant que juristes, devant ce qu’on appelle les « méfaits de la mondialisation » et la profonde crise actuelle, qui est une parfaite illustration des causes et de l’étendue des dits méfaits. L’auteur prend pour point de départ les analyses, à la fois théoriques et pratiques, des essais sur la mondialisation et le droit présentés par Juan Ramon Capella, Luigi Ferrajoli et Francisco Laporta au congrès mondial de l’Association internationale de philosophie du droit et de philosophie sociale, qui s’est tenu en 2005, et qui avait pour thème : « le droit et la justice dans une société mondiale ». L’article se termine par une série d’idées et de propositions pour s’engager moralement.
La poétique de Haeckel
Authors: Wanlin Nicolas
Published: June 2018

On examine ici tout d’abord le discours porté par le naturaliste Ernst Haeckel (1834-1919) sur la poésie et les mythes dans ses ouvrages scientifiques, oscillant entre rejet et reconnaissance. On observe ensuite comment Haeckel déploie sa propre rhétorique au service de son argumentation scientifique. Enfin, on relève des exemples de poèmes français qui font écho à Haeckel, constituant ce qu’on pourrait appeler une poésie haeckelienne.
Reproduits et réinventés : les dessins d’embryons de Haeckel
Authors: Hopwood Nick
Published: June 2018

Les innovations visuelles du « Darwin allemand », Ernst Haeckel, mettent en évidence ce qu’il peut y avoir de créatif dans le réemploi des illustrations. En focalisant l’analyse sur les dessins célèbres et controversés des embryons de Haeckel, le présent article retrace leur circulation ainsi que les accusations de falsification dont ils ont fait l’objet, du xixe siècle à nos jours, d’Allemagne aux États-Unis. En explorant les mécanismes qui déterminent le succès ou l’échec d’images, qui les font accepter ou causent des controverses, cet article montre comment le fait de reproduire ou réemployer les images peut être créatif mais aussi contesté et lourd de conséquences.
Judyta Jakubowicz et Tamerle Sonnenberg-Bereksohn
Authors: Wichrowska Elżbieta
Published: June 2018

L’article présente deux femmes d’origine juive qui ont activement participé aux transformations de la vie sociale, économique, religieuse et culturelle sur le territoire polonais au tournant du XVIIIe siècle. La première d’entre elles, Judyta (née Levi) Jakubowicz, est une Prussienne qui s’établit en Pologne, elle était la femme de Szmul Zbytkower, marchand, banquier, conseiller du roi polonais Stanisław August – un des plus importants personnages dans le monde de la finance polonaise. Elle est representative de la Haskalah et un exemple du processus d’acculturation de cette époque. La seconde est Tamerle Sonnenberg, aïeule de Henri Bergson, et comme Judyta une femme qui a réussi dans le monde des entreprises commerciales et bancaires. Non seulement elle soutint ardemment le courant hassidique mais elle le promouvait et le protégeait. Elle représente un courant de la société juive complètement différent de celui de Judyta qui était étrangère et maskila.
Le sauvetage des juifs au Chambon-sur-Lignon à travers Les Cerfs-volants de Romain Gary
Authors: Letourneau Ingrid
Published: June 2018

Dans Les Cerfs-volants (1980) Romain Gary relate la jeunesse résistante de Ludo à Cléry, un village normand inventé par l'auteur. Au sein de cette fiction, Gary, lui‑même ancien résistant aux racines juives, cite à plusieurs reprises le nom du Chambon‑sur‑Lignon, village connu pour avoir sauvé des réfugiés juifs durant la Seconde Guerre mondiale. L'hommage de Gary adopte ainsi le ton de la pudeur. Surtout, la mémoire du village se déploie à travers le personnage d'Ambroise Fleury, dont certains traits pourraient faire de lui une figure palimpseste des habitants du Chambon, une incarnation de la lutte des « armes de l'esprit » contre l'idéologie totalitaire.
L’écriture romanesque extraordinaire en hébreu de Sayed Kashua le Peptimiste
Authors: Agsous-Bienstein Sâadia
Published: June 2018

Kashua appartient à la minorité palestinienne en Israël et publie des romans en hébreu. Cet article examine l’auteur, à partir de sa posture d’écrivain translingue, et propose une analyse de son unique nouvelle (Herzl disparaît à minuit) qui aborde la fragmentation des identités (palestinienne et juive) ancrées dans l’espace divisé de Jérusalem (Est-Ouest). Cet article est tiré de la thèse de doctorat « Langues et identités : l’écriture romanesque en hébreu des Palestiniens d’Israël (1966-2013) » soutenue en 2015 à l’Institut des langues et des civilisations orientales (INALCO).
Bible et nature dans le roman Les Innocents d'Assaf Gavron
Authors: Marti-Delescaut Françoise
Published: June 2018

Les romans israéliens qui choisissent pour thème le très délicat sujet des implantations illégales (dites « colonies ») en Israël sont extrêmement rares, c'est cependant le défi qu'a relevé le jeune écrivain israélien, Assaf Gavron, dans Les Innocents (Hagiv'a – La Colline). Il y suit, pendant un an, la vie quotidienne de l'implantation Maaleh Hermesh 3 et ses démêlés incessants avec l'administration gouvernementale qui cherche en vain à les déloger. Le roman, écrit délibérément d'un point de vue interne, se caractérise surtout par ses abondantes et élogieuses descriptions du paysage et par ses non moins nombreuses références à la religion juive (Bible, Talmud, traditions), car ces implantés sont les fidèles du courant hassidique de Nahman de Bratslav. C'est ce lien que nous avons voulu explorer dans l'étude, en quoi il était caractéristique de ce type de piété et pouvait légitimer, aux yeux des personnages, l'occupation d'une terre.
L'obsession de la dualité chez Naïm Kattan
Authors: Hocquette Éric
Published: June 2018

Arrivé au Canada en 1954, Naïm Kattan, un jeune émigré juif d'origine irakienne, a réussi à s'imposer comme l'une des figures importantes de la littérature de son pays d'adoption. Fervent défenseur de la langue française, il n'en demeure pas moins un intellectuel ouvert sur le monde et sur les autres. Son style et le contenu de ses œuvres se caractérisent par une utilisation obsessionnelle, tant dans la forme que dans le fond, de la dualité qui traduit chez cet auteur prolifique une volonté de rapprocher ce que tout semble opposer en apparence.
Les cinq cents ans du Ghetto de Venise
Authors: Cazalé Bérard Claude
Published: June 2018

L’instauration du Ghetto de Venise remonte au 29 mars 1516 : il donna son nom et une forme d’institutionnalisation aux lieux de ségrégation et d’enfermement qui se développèrent en Europe et perdurèrent jusqu’à la Seconde Guerre mondiale. La particularité du Ghetto de Venise et de sa communauté ne tient pas seulement à son antériorité mais à son caractère à la fois d’insularité et d’ouverture sur le monde.
« Jérusalem n’est pas Londres » : les sionistes au lendemain de la Déclaration Balfour dans la presse hébraïque en Palestine
Authors: Kouts Gideon
Published: June 2018

Face à l’enthousiasme général qui a emporté les cercles juifs sionistes (et non sionistes) dans le monde suite à la Déclaration Balfour, ce n’est que sur place, sur les lieux du futur « foyer national » que l’impact immédiat de la grande promesse de la Déclaration Balfour, aurait pu être mise à l’épreuve. L’évolution des réactions des sionistes de Palestine est présentée et analysée à travers trois articles parus dans le quotidien Doar Hayom de Jérusalem à l’occasion du deuxième et du troisième anniversaire de la Déclaration en 1919 et 1920, dont deux signés par son directeur, le rénovateur de la langue hébraïque Éliezer Ben Yehouda, qui teste l’importance de la Déclaration par la juxtaposition du traitement qui lui est réservé à Londres et à Jérusalem.
Supporting Optimal Neurodevelopmental Outcomes in Infants and Children With Congenital Heart Disease
Authors: Peterson Jennifer K.
Published: June 2018

Improved survival has led to increased recognition of developmental delays in infants and children with congenital heart disease. Risk factors for developmental delays in congenital heart disease survivors may not be modifiable; therefore, it is important that lifesaving, high-technology critical care interventions be combined with nursing interventions that are also developmentally supportive. Implementing developmental care in a pediatric cardiac intensive care unit requires change implementation strategies and widespread support from all levels of health care professionals. This manuscript reviews developmentally supportive interventions such as massage, developmentally supportive positioning, kangaroo care, cue-based feeding, effective pain/anxiety management, and procedural preparation and identifies strategies to implement developmentally supportive interventions in the care of infants and children with congenital heart disease. Improving developmental support for these infants and children at high risk for developmental delay may improve their outcomes and help promote family-centered care.
Cattle and water buffalo densities wading into small village reservoirs of Sri Lanka impact on yields on the culture-based fisheries thereof
Authors: Jayasinghe Asanka D. , Athula J. Arachchige , De Silva Sena S. , Amarasinghe Upali S.
Published: June 2018

This study investigated whether allochthonous inputs generated by cattle and water buffaloes grazing in the catchment or wading in the water in small village reservoirs of Sri Lanka can make a significant effect on yields from culture-based fisheries of those reservoirs. The analysis is based on limnological data of 37 randomly selected reservoirs. As culture-based fish yield data were available over the 2002 - 2003 period only for 23 reservoirs, fish yield data from seven more reservoirs were gleaned for the present analysis. Cattle and water buffalo densities (BD) in 37 reservoirs where limnological data were available, were found to be significantly correlated to the biological productivity-related parameters such as chlorophyll-a content. Culture-based fish yield in the 30 reservoirs varied from 54.6 to 1800.8 kg ha-1 and BD associated with the reservoirs studied varied from 0.90 number ha-1 to 216.25 numbers ha-1. Fish yield (FY) was significantly correlated with BD the relationship being, FY = 4.758 BD + 242.740 (R2 = 0.345; p<0.001). The importance of taking into consideration factors such as grazing cattle and buffalo density in preparing management strategies for culture-based fisheries in small village reservoirs is discussed.
The Outcome of the Cryptococcus neoformans–Macrophage Interaction Depends on Phagolysosomal Membrane Integrity
Authors: De Leon-Rodriguez Carlos M. , Rossi Diego C. P. , Fu Man Shun , Dragotakes Quigly , Coelho Carolina , Guerrero Ros Ignacio , Caballero Benjamin , Nolan Sabrina J. , Casadevall Arturo
Published: June 2018

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. C. neoformans resides within mature phagolysosomes where it often evades killing and replicates. C. neoformans induces phagolysosomal membrane permeabilization (PMP), but the mechanism for this phenomenon and its consequences for macrophage viability are unknown. In this study, we used flow cytometry methodology in combination with cell viability markers and LysoTracker to measure PMP in J774.16 and murine bone marrow–derived macrophages infected with C. neoformans. Our results showed that cells manifesting PMP were positive for apoptotic markers, indicating an association between PMP and apoptosis. We investigated the role of phospholipase B1 in C. neoformans induction of PMP. Macrophages infected with a C. neoformans Δplb1 mutant had reduced PMP compared with those infected with wild-type and phospholipase B1–complemented strains, suggesting a mechanism of action for this virulence factor. Capsular enlargement inside macrophages was identified as an additional likely mechanism for phagolysosomal membrane damage. Macrophages undergoing apoptosis did not maintain an acidic phagolysosomal pH. Induction of PMP with ciprofloxacin enhanced macrophages to trigger lytic exocytosis whereas nonlytic exocytosis was common in those without PMP. Our results suggest that modulation of PMP is a critical event in determining the outcome of C. neoformans–macrophage interaction.