bluuebunny/crossref_metadata_2025 huggingface dataset:
TÜRKİYE-AZERBAYCAN DİPLOMATİK İLİŞKİLERİNDE HAYDAR ALİYEV DÖNEMİ: "TEK MİLLET-İKİ DEVLET"
Authors: ÜNALP F. Rezzan
Published: December 2023

Azerbaycan bulunduğu coğrafya, sahip olduğu petrol kaynakları dolayısıyla bölgesel ve Batılı güçlerin dikkatlerini üzerinde toplayan bir ülke olmuştur. Bu durum Türkiye Azerbaycan ilişkileri üzerinde de bir etkiye sahiptir. Sovyetler Birliği'nin 1991 yılı sonunda dağılmasıyla birlikte Kafkasya'da ortaya çıkan üç devletten -Azerbaycan, Ermenistan ve Gürcistan-biri olan Azerbaycan, bağımsızlık sonrası hem kendi içinde ve hem de dışarıya karşı birçok sorunla karşı karşıya kalmıştır. Başta Dağlık Karabağ sorunu olmak üzere Ermenistan ile yaşadığı gerginlik ve savaş hali, İran ve Rusya gibi bölgesel güçlere karşı kendini savunma ve bağımsızlığını koruma çabası, yeni ekonomi sistemine geçiş sürecinin getirdiği büyük sıkıntılar ve darboğaz, bağımsızlığını henüz yeni kazanmış ülkenin şartlarını ağırlaştırmış, istikrarsız ortam devletin güvenliğini olumsuz yönde tehlikeye sokmuştur.
Bu makalede, Haydar Aliyev'in Cumhurbaşkanlığı dönemi (1993-2003) Türkiye-Azerbaycan diplomatik ilişkileri ele alınmıştır. Bu 10 yıllık süreçte Aliyev'in devlet idaresi ve takip ettiği politikalar ile bu politikaların Türkiye-Azerbaycan ilişkilerinin seyrini belirleyen, kurulan ortaklığın derinleşmesine etki eden yönleri incelenmiştir. İki ülke arasındaki ilişkileri "Tek Millet-İki Devlet" anlayışı ile stratejik ortaklığa taşıyan Haydar Aliyev ile dönemin Türkiye Cumhuriyeti Devleti Cumhurbaşkanı Süleyman Demirel arasındaki dostane ilişkilerin bölgesel istikrarın sağlanmasındaki rolü değerlendirilmiştir. Bu kapsamda durum ve değerlendirme yöntemi esas alınarak kaleme alınmış olan makalede; Haydar Aliyev'in ülkesinin milli menfaatlerini gözeten, güçlü, dengeli bir devlet adamı olduğuna dikkat çekilmiş, iki ülke arasındaki ilişkilerin günümüze kadar dostluk ve güçlü bir stratejik ortaklık çerçevesinde gelmesinin arkasında gerek Aliyev'in ve gerekse Demirel'in yapıcı kararları ve samimi dostluk ilişkileri olduğuna vurgu yapılmıştır. 2023'ün ölümünün 20.yılı olması dolayısıyla; Türkiye-Azerbaycan arasındaki kadim dostluğun en seçkin temsilcisi olan Haydar Aliyev'i bir kez daha hatırlatmak amaçlanmıştır.
Crop DNA Extraction with Lab-Made Magnetic Nanoparticles v1
Authors: Wang Haichuan , Zhao Xueqi , Tan Li , Zhu Junwei , not provided david.hyten
Published: December 2023

Molecular breeding methods, such as marker-assisted selection and genomic selection, require high-throughput and cost-effective methods for isolating genomic DNA from plants, specifically from crop tissue or seed with high polysaccharides, lipids, and proteins. A quick and inexpensive high-throughput method for isolating genomic DNA from seed and leaf tissue from multiple crops was tested with a DNA isolation method that combines CTAB extraction buffer and lab-made SA-coated magnetic nanoparticles. This method is capable of isolating quality genomic DNA from leaf tissue and seeds in less than 2 hours with fewer steps than a standard CTAB extraction method. The yield of the genomic DNA was 582-729 ng per 5 leaf discs or 216-1869 ng per seed in soybean, 2.92-62.6 ng per 5 leaf discs or 78.9-219 ng per seed in wheat, and 30.9-35.4ng per 5 leaf discs in maize. The isolated DNA was tested with multiple molecular breeding methods and was found to be of sufficient quality and quantity for PCR and targeted genotyping by sequencing methods such as molecular inversion probes (MIPs). The combination of SA-coated magnetic nanoparticles and CTAB extraction buffer is a fast, simple, and environmentally friendly, high-throughput method for both leaf tissues and seed(s) DNA preparation at low cost per sample.The DNA obtained from this method can be deployed in applied breeding program for marker-assisted selection or genomic selection.
Graph Neural Network Framework for Web-Based Prediction of Protein-Ligand Docking Scores across multiple organs v1
Authors: S Setlur Anagha
Published: December 2023

Estimating the docking score between proteins and drugs is very important in the application of structure-based drug design. This project explores the application of Graph Neural networks (GNN) in the field of molecular property prediction using SMILES representation, the trained models are then deployed on a web-based platform for broader accessibility and use. The primary dataset utilized in this study includes molecular data represented by MolPort IDs and associated docking scores, which are critical in assessing molecular interactions. A significant aspect of this project is data preprocessing, where each molecule, initially represented as a SMILES string, is converted into a graph format. Effective molecular representation learning is pivotal to facilitate molecular property prediction. Models are then evaluated based on various performance metrics and deployed on the web-based platform. Keywords: QSAR, machine and deep learning, graph convolution networks, graph neural networks, data pre-processing, human organs, web-based predictions
MORPHOLOGICAL, AGRONOMIC, AND QUALITY PROPERTIES OF THE TWO DEVELOPED POPULATIONS OF ALFALFA (Medicago sativa L.) UNDER NON-IRRIGATED CONDITIONS OF SEMIARID REGIONS
Authors: ÜNAL Sabahaddin , EFE Berna , MUTLU Ziya , IŞIK Şaban , MİNTAŞ Hacer , HANOĞLU ORAL Hülya
Published: December 2023

Alfalfa is the most important crop in Turkey but there is no alfalfa cultivar developed for rainfed conditions under the semiarid regions in Turkey. For this reason, new cultivars are needed for using of rangeland improvement, artificial pasture establishment, and hay production. For this reason, the two alfalfa populations were developed by the mass selection method in the breeding project. These two advanced populations (L-533, and L-1739) were examined with the three control cultivars of alfalfa (Bilensoy-80, Savaş and Kayseri) for morphological, yield and quality traits in two various regions of Turkey in three experimental years. The present study results demonstrated that there were significant differences in terms of the plant height, but no differences in stem diameter, and stem number among the study genotypes. When evaluating all genotypes, the L-533 and Kayseri had the highest yield value, but the Savaş cultivar was the lowest. As compared to Bilensoy-80 cultivar, the L-533, and L-1739 populations gave higher at 22.27 and 11.57% in green forage yield; 18.30 and 10.13% in dry forage yields, respectively.

In addition, statistically significant differences were found for ADF, NDF, and digestible dry matter yield among the study genotypes, except crude protein contents. Moreover, the highest crude protein content and digestible dry matter yield were obtained from the L-533 and L-1739, but the L-533 had also the lowest NDF content. The present study result showed that the L-533, and L-1739 had high adaptation capability, excellent yield, and good quality performance in dry conditions under semi-arid regions and could be used as commercial cultivars.
IMPACT OF NITROGEN FERTILIZER ON THE PRODUCTIVITY AND QUALITATIVE PARAMETERS OF ANISE (Pimpinella anisum L.)
Authors: GEDİK Osman , AKGUL Furkan
Published: December 2023

The present study investigated the effects of nitrogen fertilization on the yield and quality characteristics of Anise (Pimpinella anisum L.). The study was conducted in the ecological conditions of Kahramanmaras from 2019 to 2021. Two different anise populations Izmir (P1) and Konya (P2) and six different nitrogen fertilizer doses (0, 30, 60, 90, 120, 150 kg ha-1) were used in the study. The experiment was set up in triplicate using a split-plot design, with the populations on the main plots and the fertilizer doses on the subplots. Considering the herbal properties of anise grown in different nitrogen dose applications; plant height was 41.71- 42.75 cm, the total number of branches (10.62-12.50 plants-1), fruit branches (4.78-5.29 plants-1) and umbrellas (8.12-9.64 plants-1) were recorded. Considering the yield and quality characteristics; seed yield the range was 350.10- 400.02 kg ha-1, 1000-seed weight 2.78-3.49 g, protein rate 15.3-17.77%, fixed oil rate 15.15-16.34% fixed oil yield 50.51-60.48 kg ha-1, essential oil rate 1.66-2.26%, and essential oil yield 5.80-8.90 L ha-1. The Konya population had higher values in terms of seed yield and quality characteristics. With the exception of plant height, which revealed the total number of branches, fruit branches, umbels, seed yield, thousand seed weight, protein ratio, fixed oil ratio, fixed oil yield, essential oil ratio, and essential oil yield, all of the studied characteristics generally showed improvement with an increase in nitrogen doses. However, a nitrogen treatment of 120 kg ha-1 produced the maximum seed production.
Family Collemataceae in the lichen flora of the Magadan Region, Russia
Authors:   Central Siberian Botanical Garden SB RAS, Makryi Tatiana V. , Zheludeva Elena V. ,   Institute of Biological Problems of the North FEB RAS
Published: December 2023

The localities of sixteen species of cyanolichens of the family Collemataceae Zenker discovered in the Magadan Region are provided. Collema glebulentum (Cromb.) Degel. is recorded for the first time in the Russian Far East. Fourteen species are new for the Magadan Region. Collema furfuraceum (Arn.) DR., C. subflaccidum Degel., Leptogium saturninum (Dicks.) Nyl., Rostania occultata (Bagl.) Otálora, P.M. Jørg. et Wedin, Scytinium teretiusculum (Wallr.) Otálora, P.M. Jørg. et Wedin live as epiphytes in poplar-chosenia forests along the valleys of large rivers. Collema pulcellum Ach., C. flaccidum (Ach.) Ach., Leptogium cf. hirsutum Sierk occur in habitats unusual for them – in the subalpine mountain belt. Leptogium cyanescens (Ach.) Körb. was found only on the coast of the Sea of Okhotsk. All lichens are rare and occur in special habitats, manly refugia. Most species were found on the Olskoye Basalt Plateau and the Atargan Peninsula. The localities of Collema pulcellum, Leptogium cyanesces, L. cf. hirsutum are outside their ranges; these lichens are relics of the Miocene-Pliocene mesophilous flora.
Educational and local history excursion «Natural and cultural heritage of Bylotserkivshchyna» from the «Meridian» Tourist Center
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Rudenko A. , Burachok V. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Gryniuk O. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2023

By studying local aspects, local history helps reveal the unique features and traditions of each region, enriching the understanding of its past and present. While tours provide an opportunity to immerse yourself in the history, culture and nature of a particular region through a personal interactive experience. The article examines the importance of local history, examines its history and current stage of development. Various classifications of excursions and their forms of conduct are outlined. Special emphasis is placed on the importance of educational and local history excursions for students. The organizational requirements for conducting student excursions were also considered, including the selection of objects and the development of an educational and local history excursion entitled «Natural and cultural heritage of Bilotserkivshyna».
Geographical competence and global challenges of our time
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Pylypiak M. , Gryniuk O. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2023

Geographical education is an important part of the present, and in order for it to be qualitative, it is necessary to master a number of competencies. This is especially true now, when the world is faced with many global challenges. Geographical competence plays an important role in the formation of an educated, globally oriented personality capable of understanding and responding to complex challenges that arise in the modern world. Having mastered geographical competencies, students and adults will not only have knowledge of this field, but will also be able to independently analyze world problems from a geographical point of view. The work analyzes the origin and concept of the general term "competence," and reveals the essence of the concept of "geographical competence." Particular attention in the work is paid to the formation of these competencies in students in geography lessons, and it is shown what role geographical competence plays in understanding global challenges on specific examples.
HARMONY AND RELIGIOUS TOLEANCE BETWEEN THE ARABIC AND UKRAINIAN COMMUNITIES
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kharkovshchenko Yevhen , Alrub Emad Abu ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2023

The subject matter of the study is provision of conditions and finding ways of improvement the efficiency of mutual understanding and tolerance between the Arabic and Ukrainian communities. There have been stressed the importance of human rights and causes of occurrence of religious conflicts, as well as ways of settling that kind of problems have been put forward. Particularly, we focus in this study on the needs to study the Moslem Laws on the basis of the principal respective source – The Holy Writ The Koran, so as to conceive objectively foundations of the religious and legal norms related to providing human rights and obligations, as well as that of a joint peaceful life of and mutual undersatanding between the Ukrainian and Arabic communities within a united society. Besides, this paper deals with the Russian War against Ukraine, that is directed at ruining the spiritual and cultural values, and that produces threats to the religious security in general. The conclusion of the study having been made is that under the conditions of the world globalisation it is impossible to overcome completely the problem of occurrence of religious conflicts, but those ones could be prevented by means of a respective method of studying objectively and implementing practically into everyday life the religious moral and legal norms.
MAIN ACTIVITY OF MUSLIM ORGANIZATIONS OF UKRAINE IN 2022
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Gotska Ievgeniia
Published: December 2023

The activity of the Muslim communities of Ukraine during the Russian Federation war, due to the involvement of Muslims in social processes, military actions and migration processes of a multi-confessional state, is considered. In the article, we were selected the main areas of activity of Muslim organizations: protection of the state borders and territories of Ukraine, cooperation and consolidation of the Muslim Ummah to help the civilian population and the military of the Armed Forces with the necessary help and directly volunteer work. The article also examines such an important element of the activities of Muslim communities as cooperation with authorities in order to establish productive relations among Muslim organizations and the Muslim world as a whole.
A Study on impact of Perceived Supervisor Support on Employee Stress in Aviation Sector
Authors: Hasijani Gunjan
Published: December 2023

Purpose: The purpose of this study is to find the impact of Perceived Supervisor Support on Stress.

Design/Methodology/Approach: This study is based on descriptive cum causal research design and a sample of 200 employees was randomly selected from various Aviation employees working at the ground level. 

Originality/value: The study examined the impact of Supervisor’s Support on Employee Stress.
Effect of Inorganic, Organic Nutrient Sources and Bio-Fertilizers on Growth Attributes, Biomass at Flowering and Nodule Weight of Phaseolus vulgaris (Rajma)
Authors: Vitthal Andhale Atmaram , Chate S. P.
Published: December 2023

It is essential to adopt new techniques and management practices as integrated nutrient management. The combined use of organic, inorganic manures and bio-fertilizer not only increases the crop yield but also improves the physical, Chemical and biological properties of soil. As enhance these properties, we can enhance the growth rate at flowering and nodule weight of plant, Phaseolus vulgaris. It did positive impact on quality and yield of Rajama. To study this, nine treatments, three replications, RBD design and Dibbling sowing method was adopted. The growth and yield attributes i.e. height, number of branches plant-1, Number of pods plant-1, number of grains pod-1 were recorded highest when only inorganic fertilizers @ 150% RDF was applied and these plant characters were recorded lowest when only vermicompost was applied.  Biomass production at flowering, grain and straw yield were highest due to application of 150% RDF of NPK through inorganic fertilizers.  The lowest biomass production at flowering was recorded where 2.5 t vermicompost at sowing and 50 % N through urea at flowering were applied. The lowest grain yield and straw yield was recorded when only vermicompost @ 5 tonnes ha-1 was applied.  Fresh weights of nodules were negligible.
Variables Affecting Psychological Health and Their Relationship to Job Performance Among Faculty Members (A Field Study on The College of Education at The University of Hail)
Authors: Alkfare Wedad Mohammad Saleh , Alshammari Rehab Mujzi Radhi
Published: December 2023

The current study aimed to determine the faculty members' level of awareness of the factors affecting their psychological health and level of job performance at the College of Education at Hail University, as well as whether there is a correlation between their level of awareness of the factors affecting their psychological health and level of job performance. This study took a descriptive methodology. 87 faculty members from the College of Education at Hail University, including both genders, made up the study sample. Two measures were created to accomplish the study's goals: one to gauge the degree of faculty members' knowledge of factors relating to their psychological health, and the other to gauge the quality of their work output. The study found that faculty members performed at a high level on the job but had limited awareness of the factors affecting their psychological health. It also showed that there was no statistically significant correlation between faculty members' levels of psychological health and their levels of job performance at the University of Hail's College of Education. In light of the study's findings, it is advised the report emphasizes the necessity for University of Hail administrators to focus on improving academic members' mental health.
Evaluation of Association Between High Frenal Attachment and Severity of Midline Diastema
Authors: P S Samyuktha , Kumar M Dr. Naveen
Published: December 2023

Introduction: A "midline diastema" arises when there is a space of more than 0.5 millimeters between the proximal surfaces of two consecutive teeth. There is usually open space between the two central incisors. Depending on its width, a midline diastema can make speaking difficult and look unsightly.  Genetic factors, large tongues, improper tongue positioning during rest or function, microdontia or hypodontia of upper lateral incisors, extra teeth between upper central incisors, particularly mesiodens, aberrant frenal attachment, periodontal disease, and extra teeth are some of the multifactorial causes of midline diastema. The aim of this study is to assess the association between high frenal attachment and the severity of midline diastema. Materials and method: The study involved 126 patients. We assessed the frequency of high frenal attachment and midline diastema in these patients. The Chi square test was used to examine the data in the SPSS Software. Results and discussion: The current study has arrived at a positive correlation between the frenal attachment type and the severity of the midline diastema space. Midline diastema might be transitory or result from pathogenic, developmental, or iatrogenic reasons. Treatment options for diastema vary, and each one calls for an accurate etiology diagnosis and prompt action appropriate to that etiology. A correct diagnosis needs radiographic and clinical examination, medical and dental history, and perhaps tooth size assessment. Conclusion: Within the limitations of the study, it can be concluded that there is a positive correlation between the frenal attachment type and the severity of midline diastema space. It was also observed that the most common frenal attachment type was papillary type and the space more commonly was 2-3 mm in length.
Detection of Suspicious Activity using Mobile Sensor Data and Modified Sub-space K-NN for Criminal Investigations
Authors: Aloni Sukhada , Shekhawat Divya
Published: December 2023

With the bulk availability of mobile sensors, the data collected from them mustn’t be wasted. Nowadays the creation of black-box software that collects this data is not a very difficult task. It is possible to detect suspicious unlawful events using this black-box data. In this paper, we present a novel way of doing forensic investigation using a modified sub-space K-NN (MSK) algorithm. The MSK algorithm is capable of detecting suspicious activities from mobile sensor data. Using this technique, we could detect any normal activity versus suspicious activity with 99.7 % accuracy. This study lays the foundation for future explorations, envisioning potential applications in diverse fields, including zoology. By adapting and expanding the proposed methodology, researchers in zoology could harness mobile sensor data to study animal behavior, offering an innovative approach to understanding and monitoring wildlife activities. Such interdisciplinary bridges highlight the versatility of technological advancements, where tools developed for criminal investigations may find unexpected yet valuable applications in the study of zoological phenomena
The Dimensional Changes of Clasp Arm in Removable Partial Denture Frameworks Fabricated Through DMLS and Conventional Lost Wax Technique: An In Vitro Study
Authors: Sai K Lokesh , Venugopalan Suresh
Published: December 2023

AIM: The aim of the present study is to evaluate the effect of CAD designing on the dimensions of the clasp arm. METHODOLOGY: A Kennedy Class III mod I cast was selected as the reference cast. Samples were divided into 2 groups, Group I with DMLS and Group II with Conventional lost wax technique. Three reference points were selected on the clasp arm and the vertical dimensions were measured in the digital design and compared it with the dimensions at the same points in the final framework. RESULTS: There was slight expansion in group 1 (p-value > 0.05) with mean of -0.035 and standard deviation 0.088. And there was decrease in dimensions in the clasp arm in group 2 (p-value < 0.05) with mean of 0.1741 and standard deviation 0.081. CONCLUSION: From the present study, it was concluded that the dimensions of the clasp arm of DMLS framework increased slightly, whereas the there was significant decrease in the clasp arm dimensions in the framework produced through conventional lost wax technique. Both the frameworks had clinically acceptable fit.
A Study on Income and Expenditure Pattern of Fishermen During Fishing Holiday Period in Kakinada Harbour, Andhra Pradesh
Authors: Venu Dr. A. , Lakshmi Ms. M. Vara , Latha Dr. D. Asha
Published: December 2023

India is the second leading fish producing country in the world accounting for 7.56 per cent of global production. Fisheries sector plays an important role in the Indian economy through contributing national income, employment creation; promote exports, provides food and nutritional security. Andhra Pradesh has favorable agro-climatic conditions for the growth of fisheries and aquaculture sector. The State is contributing about 29.7% of national fish production and is a major exporter of shrimp in India with share of 40.4% in total value of sea food exports of the country during 2019-20. The sector is providing employment to nearly 26.5 lakhs. Andhra Pradesh has 26 coastal districts. The present study analyzing the socio-economic status of fishermen and various problems encountered by the fishermen during fishing holiday period in the study area. To analyze the income and expenditure pattern and asset structure of fisher households. This study is confined to Kakinada Harbour Area. A major proportion of the sample respondents were joined in fishing due to poverty i.e. 45 per cent, a higher proportion of the respondents (67%) are living in nuclear family, Major proportion of respondents had 11-20 years of fishing experience (42%), followed by 21-30 years (24%), 1-10 years (17%) and more than 30 years (16%), 97 per cent of respondents are living in the pucca and semi-pucca houses
Videoassistirovannye operatsii pri opukholyakh shchitovidnoy zhelezy s biopsiey storozhevogo limfaticheskogo uzla
Authors: Chissov V I , Reshetov I V , Golubtsov A K , Sevryukov F E , Krekhno O P
Published: December 2023

The paper describes the procedure for mini-invasive lateral-access video-assisted resection of the thyroid in its tumors, which has been tested in cadaver experiments. The length of skin incision varied between 2.0 and 3.0 cm, depending on the length and thickness of the neck. There were no problems in imaging the recurrent laryngeal nerve and in exposing the superior and inferior thyroid arteries. The parathyroids were difficult to visualize in some cases. With lateral access, the distance to cervical structures averaged 3.0 and 3.0 cm to the superior and inferior thyroid arteries, respectively; it did 3.5 cm to the recurrent laryngeal nerve. The pretracheal and paratracheal fats, the nearest regional metastasizing areas, could be adequately revised in all cases.
Video-assisted resection of the thyroid was clinically used in 135 patients in the treatment of benign and low-grade malignant thyroid tumors (T1-2NxM0). Surgery was performed in 120 women and 15 men; their age was 40.9 years. Preoperative cytological studies revealed papillary/follicular adenoma and low-grade adenocarcinoma (T1-2N0M0) in 92 and 52 patients, respectively. The surgical interventions were hemithyroidectomy with isthmusectomy and subtotal thyroid resection, sentinel lymph node biopsy was made in 18 patients.
On the basis of topographic and anatomic studies, the authors have proven the principal possibility of adequate thyroid resection through the mini-invasive lateral access; the latter allows biopsy of the sentinel lymph node of thyroid cancer; hemithyroidectomy with the determination of the sentinel lymph node through a mini-invasive lateral approach reduces operative time and blood loss and does not increase the frequency of postoperative complications, decreases postoperative hospital bed/days to 2-3 days, results in a good cosmetic scar, and does not impair cervical organ function. The indications for mini-invasive lateral-access hemithyroidectomy are adenoma of the thyroid and its low-grade cancer (T1NxM0); the relative indications are female gender and under 60 years of age.
Varianty rezektsii pecheni pri zlokachestvennykh opukholyakh
Authors: Chzhao A V , Kovalenko Yu A , Chugunov A O , Navruzbekov M S
Published: December 2023

The paper analyzes the results of surgical treatment in 85 patients with malignant liver tumors. According to the nature of a tumor process, all the patients were divided into two group: 1) 16 (18.8%) patients with hepatocellular carcinoma (HCC) and 2) 69 (81.9%) with colorectal cancer liver metastases (CCLM). The staging distribution of patients was as follows: 1) (TNM) 7 (43.7%) patients with Stages II-III and 9 (56.3%) with Stage IVA; 2) mTNM) 1 (1.4%) patient with Stage I, 12 (17.4%) with Stage II, 15 (21.7%) with Stage III, and 31 (44.9%) with Stage IVA, and 10 (14.5%) with Stage IVB. Choice of a resection mode was determined by the clinical and pathological factors of a tumor and the functional reserve of the liver. Extended hemihepatectomy (EHH) was carried out in 6 patients with HCC; hemihepatectomy (HH) in 2; bisegmentectomy in 2, and segmentectomy in 1; nonanatomic resections in 4; a combination of anatomic and non-anatomic resections in 1. Fifty-three (77%) and 7 (10%) patients with CCLM underwent anatomic and anatomic resections, respectively; a combination of both resection modes was performed in 9 (13%0 cases. According to the volume of anatomic resection, the patient distribution was as follows: EHH in 15 (28%) patients, HH in 21 (40%), bisegmentectomy in 7 (15%), and segmentectomy in 10 (19%). The preoperative risk for hepatic failure was assessed by ultrasonography and a methacetin breath test. No extensive resection was made if the hepatectomy index was less 3.8%. Postoperative complications occurred in 4 patients with HCC. Post-CCLM mortality was 4.3%. In patients with HCC, 5-year survival was 48%; in those with CCLM, 5-year overall and relapse-free survival were 35.1 and 22.4%, respectively.
Kliniko-geneticheskoe issledovanie papillyarnogo i follikulyarnogo raka shchitovidnoy zhelezy
Authors: Kazubskaya T P
Published: December 2023

Hereditary predisposition to thyroid cancer (TC) was studied in 40 patients with this condition, out of whom 74% were observed to have papillary cancer; papillary-follicular and follicular cancers were found in 23 and 3%, respectively; and their 912 first-degree relatives. For the convenience of analysis, these histological forms were integrated into nonmedullar TC (NMTC). The risk of NMTC was ascertained to be higher in women than that in men (the male/female ratio was 1:5). The age at disease diagnosis averaged 47.7% years; however, in 78% of the patients the first signs of the disease occurred an average of 6-7 years earlier. There was a significant trend for various organs to be involved; the rate of primary-multiple malignant neoplasms were 5.4%, by exceeding the similar rate in the population manifold (0.003%). Analysis of the relatives' diseases revealed that 4% of them were affected by various neoplasias and 3.2% were by various benign thyroid tumor and nontumor diseases. NMTC was found to have a family component. The age at the manifestation of familial papillary TC (32.1% years) was much less than that in the total sample of patients with NMTC, indicating a severer phenotype. The detected familial cases of papillary TC were referred to as familial papillary TC, in which only thyroid tissue is involved. Papillary and follicular TC may be a component of hereditary syndromes. It was suggested that there were general regularities in tissue lesions of the thyroid, kidney, breast, skin (melanoma), nervous system, and large bowel in the family of patients with NMTC. Recommendations are proposed for the management of hereditary TC forms.
Khirurgicheskoe lechenie bol'nykh s metastazami kolorektal'nogo raka v pecheni i legkikh
Authors: Vishnevskiy A A , Vishnevskiy V A , Ionkin D A , Pikunov M Yu
Published: December 2023

The authors give data on 39 patients operated on for colorectal cancer metastases to the liver and lung. Resurgeries were made in 6 cases. Predictors were defined. In patients with simultaneous metastases, 3-year survival was 36% with a median of 21 months and in those with metachronic metastases, it was 69% with a median of 31 months. Better results were obtained in the patients who had undergone hepatectomy and, following 2-3 weeks, metastasis removal from the lung particularly when secondary foci were detected only 6 months or more after primary tumor removal.
Algoritm meropriyatiy dlya profilaktiki i lecheniya gnoynykh oslozhneniy ran u onkoginekologicheskikh bol'nykh
Authors: Ismailova L V , Krikunova L I , Berdov B A , Efendiev V A
Published: December 2023

The risk factors of pyoinflammatory complications of postoperative wounds during elective surgery were studied in gynecological and gynecological cancer patients. An algorithm was developed and described for measures to prevent infectious postoperative wound complications and their treatment. The above algorithm makes it possible to reduce the frequency of infectious complications, wound and abdominal abscesses, peritonitis by 2.5-fold and the length of stay in bed. The results of magnetic laser therapy used to prevent pyoinflammatory complications of wounds are given.
VLIYaNIE BIOLOGIChESKIKh OSOBENNOSTEY OPUKhOLI NA KLINIChESKIE VARIANTY METASTAZIROVANIYa RAKA MOLOChNOY ZhELEZY V LEGKIE
Authors: Andreyashkina I I , Plokhov V N , Konopatskova O M
Published: December 2023

The paper presents the results of a study dealing with the determination of the impact of the specific features of a tumor on the variants of breast cancer metastazing to the lung and two groups of patients with early and late breast metastases to the lung are identified.
Prognozirovanie rezul'tatov lecheniya bol'nykh kolorektal'nym rakom s mnozhestvennymi metastazami v pecheni
Authors: Islamov Kh D , Navruzov S N , Abduzhabbarov S B , Gil'dieva M S
Published: December 2023

Colon cancer is one of the most common malignancies, which annually afflicts as high as 1 million people worldwide. In 20% of patients with colon cancer, its distant metastases primarily to the liver are detectable at diagnosis; metastases develop in the course of the disease in 50%, which become a cause of their death. Expression of p53 in relation to the morphological characteristics of the primary colon tumor spreading to the liver is one of the negative predictors of the course of the tumor process in colorectal cancer that worsens the prognosis of the disease and greatly affects the efficiency of used chemotherapy regimens. The chemotherapy regimen FOLFI-RE overcomes drug resistance in tumor cells, which further permits a positive treatment response to be achieved in most patients.
Termografiya v diagnostike i opredelenii ob\"ema khirurgicheskogo vmeshatel'stva pri pigmentnykh opukholyakh kozhi
Authors: Konopatskova O M , Bukina Yu V , Terentyuk G S
Published: December 2023

The paper presents the results of using thermography to diagnose pigmented nevi and to define a surgical scope.
Synchronous polyneoplasias in patients with gastric cancer: clinical and morphological regularities, treatment results
Authors: Skoropad V Yu , Berdov B A , Skoropad V Yu , Berdov B A
Published: December 2023

The paper analyzes synchronous polyneoplasias in radically operated patients with gastric cancer, which were detected in 2.9% of cases, including 7.3% among the patients with early gastric cancer. Among second tumors, there was a preponderance of neoplasms of the colon, urinary bladder, throat, lung, and kidney. Preoperative examination of patients with gastric cancer should exclude synchronous tumors of the most common sites. Conversely, gastroscopy should be included in a diagnostic algorithm for patients with the above neoplasms to exclude gastric cancer. Synchronous multiplicity of the disease is shown to be a contraindication to the radical treatment of each neoplasm. If reasonably effective palliative therapy for a second tumor can be performed during its generalizations, radical surgical treatment for gastric cancer is warranted. If there are technical feasibilities and the patient's functional status is adequate, simultaneous removal of both tumors is the method of choice. Radical treatment for synchronous tumors ensures high survival rates. In this patient category, the cardinal cause of death is second tumor progression, which is associated with the predominance of early gastric cancer.
Redkoe klinicheskoe nablyudenie gigantskoy nekrotiziruyushcheysya epiteliomy Malerba temenno-zatylochnoy oblasti
Authors: Reshetov I V , Kravtsov S A , Anurova O A , Batukhtina E V , Antonenkova E N , Toporov E N , Sidletskiy V Ya , Chervov A Yu , Kirillov N V
Published: December 2023

The authors report a rare case of Malherbe's giant epithelioma in the parieto-occipital region. Emergency surgery under local anesthesia could preserve the life of a female and realize a radical surgical treatment plan. The uniqueness of this case is due to the fact there are no reports of such cases in the available literature.
Surgical tactics for hemorrhage-complicated gastric cancer
Authors: Repin V N , Kostylev L M , Gudkov O S , Tsoy S K , Repin V N , Kostylev L M , Gudkov O S , Tsoi S K
Published: December 2023

The paper presents diagnosis and surgical tactics while treating 219 patients with gastric cancer. Carcinoma was present in the cardia in 26% of the patients, in the body in 37.9%, in the anthral part in 17.8%, total lesion in 12.8%, and stump cancer in 5.5%. Seventy-four (33.8%) patients with arrested bleeding were recognized as inoperable; 145 patients were operated on. Emergency operations were performed in 28 patients; urgent operations due to threatening recurrent hemorrhage and delayed ones were in 14 and 103 patients. Gastrectomy with lymphodissection D2 was carried out in 78 (54.6%) patients and subtotal gastric resection was in 40 (28%); the other patients underwent palliative operations. Mortality was 14.3 and 21.4% after radical and palliative surgery, respectively. After radical operations, 66.1 and 32.9% survived 3 and 5 years, respectively.
VOZVRAShchENIE OTEChESTVENNOGO OPIOIDNOGO ANAL'GETIKA PROSIDOLA V KLINIChESKUYu PRAKTIKU ROSSIYSKOY ONKOLOGII
Authors: Abuzarova G R , Osipova N A , Danilova T V , Petrova G V
Published: December 2023

The paper describes the Russian opioid analgesic prosidol: its benefits and adverse reactions, its place in therapy for cancer pain. The authors consider the therapeutic equivalence and clinical efficacy of the drug from the results of its clinical trials and their experience. A pharmacoeconomic analysis of prosidol versus the similarly effective agent promedol is given, which emphasizes the economic expediency of prosidol therapy,is given
Reconstructive-plastic and combined operations in patients with lung cancer during neoadjuvant chemotherapy and intraoperative radiation
Authors: Miller S V , Zav'yalov A A , Tuzikov S A , Efimov N P , Dobrodeev A Yu , Polishchuk T V , Yumov E L , Miller S V , Zavyalov A A , Tuzikov S A , Efimov N N , Dobrodeev A Yu , Polishchuk T V , Yumov E L
Published: December 2023

The authors studied the results of reconstructive-plastic and combined operations when neoadjuvant systemic anti-tumor treatment and intraoperative radiotherapy were performed in patients with locally advanced non-small cell lung cancer. Additional chemoradiation was found to have no substantial impact on its postoperative course, to reduce the number of patients with disease progression, and to increase relapse-free and overall survival.
Issledovanie kachestva zhizni pri lechenii kolorektal'nogo raka
Authors: Pomazkin V I
Published: December 2023

The paper gives the data available in the literature on quality of life (QL) in patients treated for colorectal cancer. Studies of QL in the treatment of colorectal cancer along with the traditional qualitative parameters are promising in evaluating the efficiency of anti-tumor exposures.
Organosokhranyayushchee lechenie bol'nykh rakom pochki
Authors: Teplov A A , Rusakov I G , Smirnova S V , Zakharova M A , Andreeva Yu Yu , Sidorov D V
Published: December 2023

The authors analyze the results of treatment in 124 patients with renal cancer who have undergone 127 kidney resections. Follow-ups lasted 1 to 97 months (mean 14.6 months). Early postoperative complications were recorded in 27 (21.3%) cases. Mortality was 0.8%. A recurrent tumor was found at the site of kidney resection in 3 (2.4%) patients with renal cancer T1aN0M0, grade 2-3, at 14 to 23 months, among them there was one (0.8%) patient after horseshoe kidney resection.
Open renal resection has demonstrated good oncological and functional results and is the operation of choice for patients with renal cancer, but it requires a preoperative careful diagnosis comprising contrast 3D computed tomography and/ or magnetic resonance imaging, as well as angiography in order to define the anatomic relationships between the renal structures and a tumor.
Intraoperative radiotherapy with cisplatin radiosensitization during combination treatment for Stage III lung cancer
Authors: Dobrodeev A Yu , Zav'yalov A A , Tuzikov S A , Musabaeva L I , Miller S V , Vorob'ev A V , Dobrodeev A Yu , Zavyalov A A , Tuzikov S A , Musabayeva L I , Miller S V , Vorobyev A V
Published: December 2023

The results of combination treatment with neoadjuvant chemotherapy (NACT) (paclixel/carboplatin), radical surgery, and intraoperative radiotherapy (IORT), 10 Gy, during cisplatin radiosensitization were compared with those of radical surgery and IORT, 15 Gy, in 70 patients with stage III non-small cell lung cancer. NACT and additional use of cisplatin in a dose of 6 mg/m2 as a radiosensitizer during IORT could reduce a single radiation dose from 15 to 10 Gy and the incidence of postoperative pneumonias; there was a statistical significant increase in 2-year overall (88.4±6.2%) and relapse-free (84.6±7.1%) survival (p < 0.05).
KLINIChESKAYa ZNAChIMOST' MORFOLOGIChESKOY KLASSIFIKATsII GIPERPLASTIChESKIKh PROTsESSOV ENDOMETRIYa
Authors: Pronin S M , Andreeva Yu Yu , Novikova E G , Anpilogov S V
Published: December 2023

The paper presents the current morphological classifications of endometrial hyperplastic processes and their clinical value in choosing a treatment policy for patients with this pathology.
Impact of anti-inflammatory therapy on the effects of photodynamic exposure in an experiment
Authors: Karmakova T A , Vorontsova M S , Venediktova Yu B , Yakubovskaya R I , Karmakova T A , Vorontsova M S , Venediktova Yu B , Yakubovskaya R I
Published: December 2023

A model of transplantable mouse sarcoma S-37 was used to show that the administration of anti-inflammatory drugs (ketonal and contrical) in therapeutic doses after photodynamic therapy (PDT) not only reduces the magnitude of photo-induced local tissue reactions, but may potentiate, in certain regimens, the therapeutic effect against the growth of primary tumor and metastases. The most signifiсant anti-tumor effect of PDT was observed when ketonal and contrical were coadministered twice 1 and 5 hours after light exposure. The study of the microvascular bed in the tumor growth area, by using immunohistochemistry with antibodies to the vascular endothelium (anti-CD31), has indicated that neovascularization processes are inhibited at the site of exposure when ketonal and contrical are given in the above regimen after PDT. The anti-inflammatory drug-potentiated antitumor effect of PDT is presumed to be caused by the inhibition of mediators of the exudative photo-induced nonspecific inflammation phase followed by delayed microvascular regenerative proliferation and prolonged injured tissue ischemia.
Intraoperative fluorescence diagnosis and photodynamic therapy in patients with brain metastatic involvement
Authors: Chissov V I , Filonenko E V , Reshetov I V , Zaytsev A M , Loshakov V A , Kurzhupov M I , Shelesko A A , Yanikova A G , Loshchenov V B , Frank G A , Bobrov A N , Chissov V I , Filonenko E V , Reshetov I V , Zaitsev A M , Loshakov V A , Kurzhupov M I , Shelesko A A , Yanikova A G , Loshchenov V B , Frank G A , Bobrov A N
Published: December 2023

With advances in neurosurgery, stereotactic radiosurgery, fluorescence diagnosis (FD), and photodynamic therapy (PDT), there have been changes in treatment policy and an increase in survival among patients with brain metastatic involvement. The paper gives the results of treatment for brain metastastic involvement, by using the procedures of intraoperative FD and PDT with Alasens.
Intraoperative fluorescence diagnosis of breast cancer metastases into the regional lymph nodes
Authors: Pak D D , Filonenko E V , Frank G A , Barsamyan G S , Efremov G D , Pak D D , Filonenko E V , Frank G A , Barsamyan G S , Efremov G D
Published: December 2023

Intraoperative fluorescence diagnosis (FD) of breast cancer (BC) metastases into the regional lymph nodes was made in 51 patients who were divided into 2 groups: 1) 43 patients who had undergone surgical treatment in the first stage; 2) 8 who had received 2 to 4 courses of neoadjuant chemotherapy in the first stage and had been operated on in the second stage. Intraoperative FD was made using Alasens. Alasens-induced protoporphyrin IX fluorescence was assessed, by applying the methods of visual fluorescence determination and local fluorescence spectroscopy. The investigators examined a total of 384 lymph nodes, including 312 and 72 nodes in Groups 1 and 2, respectively. In Group 1, the sensitivity and specificity of the method were 84.8 and 84%, respectively; in Group 2, these were 69.4 and 78%. The first experience in using intraoperative FD of metastatic involvement in the regional lymph nodes in patients with breast cancer showed the high efficiency of and promise for this method.
Lymphatic spread of distal gastric cancer
Authors: Akhmedzyanov F Sh , Kitaev M R , Yadykov O A , Akhmedzyanova F F , Akhmedzyanov F Sh , Kitayev M R , Yadykov O A , Akhmedzyanova F F
Published: December 2023

The specific features of lymphatic cancer spread were studied in 180 patients with distal gastric cancer in relation to the segmental gastric structure. The site of metastases and the direction of their spread were revealed depending on the site of a tumor in the gastric wall. The volume of surgical intervention was proposed in distal gastric cancer.
Therapeutic pathomorphism in patients with non-small cell lung cancer during multimodality treatment
Authors: Dobrodeev A Yu , Vasil'ev N V , Zav'yalov A A , Tuzikov S A , Miller S V , Vorob'ev A V , Dobrodeev A Yu , Vasilyev N V , Zavyalov A A , Tuzikov S A , Miller S V , Vorobyev A V
Published: December 2023

Therapeutic pathomorphism was studied in 69 patients with stage III non-small cell lung cancer during multimodality treatment with neoadjuvant chemotherapy with paclixel/carboplatin. Complete regression of the tumor was achieved in 5.8±2.8% of cases with fourth-degree pathomorphism, in 37.5±5.8% of those with its third-degree, in 44.9±5.9% of those with second-degree, and in 11.6±3.8% with first-degree. High-grade carcinomas (G3) were found to be most susceptible to chemotherapy; second-third-degree therapeutic pathomorphism developed in 38.6% of patients with squamous cell lung cancer and in 65.2% of those with adenocarcinomas. In moderate-grade carcinomas (G2), second-third pathomorphism was observed in 29.5 and 21.7%, respectively (p < 0.05). There was a direct relationship between the long-term results (time to disease progression) and the short-term overall chemotherapy response and the degree of the pathomorphism.
Sravnitel'naya kliniko-diagnosticheskaya znachimost' nekotorykh serologicheskikh opukholeassotsiirovannykh markerov dlya razlichnykh gistologicheskikh tipov raka legkogo
Authors: Marshutina N V , Sergeeva N S , Trakhtenberg A Kh , Parilova N K , Solokhina M P , Vursol D A , Sergeeva V S
Published: December 2023

The authors selected a combination of serological tumor-associated markers for each histological type of tumors to enhance the sensitivity of clarifying laboratory diagnosis and monitoring of patients with lung cancer (LC). The serum levels of carcinogenic embryonic antigen (CEA), SCC, Cyfra 21-1, and ProGRP were studied in 57 primary patients with Stages I-IV LC of various histological types (squamous-cell and small-cell carcinoma, adenocarcinoma), in 12 patients with noncancer lung diseases, and in 13 healthy individuals. The highest sensitivity was demonstrated by the combined determination of Cyfra 21-1 and SCC for squamous-cell LC (88.2%) and that of CEA and Cyfra 21-1 for lung adenocarcinoma (57.1%). On a small sample of patients, the new serological marker ProGRP showed not only a high sensitivity (75%) for small-cell LC, but also a high specificity (94.3%) for non-small-cell LC. These results agree with few data in the foreign literature and suggest that the marker should be used for the specifying differential diagnosis of small-cell LC and the monitoring of patients with type of LC.