bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Safety of Erenumab, Galcanezumab, and Fremanezumab in the Treatment of Drug-Resistant Chronic Migraine: Experience in Real Clinical Practice
Authors: Cantarelli Lorenzo , Pestana Grafiña Diana , Gonzalez Perez Amanda , García Gil Sara , Gutiérrez Nicolás Fernando , Ramos Santana Emma , Navarro Dávila Marco Antonio , Otazo Pérez Sheila María , Calzado Gómez Gloria , Perez Reyes Sergio , Nazco Casariego Gloria Julia
Published: August 2022

Background:

Due to the recent introduction of new biologic drugs for chronic migraine, a global evaluation in real clinical practice is necessary.

Objective:

The objective was to evaluate the effectiveness and safety in real clinical practice of drugs targeting the calcitonin gene-related peptide receptor (CGRPr) in patients with chronic migraine.

Methods:

Single-center, restrospective study (2019-2022), including patients with chronic migraine treated with erenumab, galcanezumab, or fremanezumab. Effectiveness variables were recorded, namely, number of migraine headache days per month (MHD), Migraine Disability Assessment Scale (MIDAS) score, and Headache Impact Test–6 (HIT-6) score, assessing changes at week 12, 24 from baseline. Toxicity was recorded following the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 criteria.

Results:

In all, 104 patients were included (46.2% erenumab, 41.3% galcanezumab, 12.5% fremanezumab). A reduction in MHD, MIDAS, and HIT-6 was achieved at weeks 12 and 24 with erenumab (p75% at week 24 than those intensified; P = 0.041). There was no difference in efficacy ( P = 0.154) or improvement in quality of life ( P = 0.783, P = 0.150), but there was greater toxicity ( P < 0.001) among nonresponders with erenumab 70 mg versus erenumab 140 mg.

Conclusions:

The results confirm the effectiveness and safety of anticalcitonin gene-related peptide (CGRP) drugs in real clinical practice. However, the study shows little benefit from erenumab intensification, with similar effectiveness and worse tolerability than the standard dose.
Analysis and Prediction of the Survival Trends of Patients with Clear-Cell Renal Cell Carcinoma: A Model-Based Period Analysis, 2001-2015
Authors: Du Sicong , Zhong Yu , Zheng Shuai , Lyu Jun
Published: August 2022

Background

Clear-cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors worldwide whose poor prognosis results in a serious disease burden on patients. The changing trend of the long-term relative survival rates (RSRs) of patients with ccRCC was analyzed in this study to evaluate their treatment results over a 15-year period.

Methods

This study is a retrospective study, which assessed and predicted the 1-, 3-, and 5-year survival rates of patients with ccRCC during 2001-2005, 2006-2010, 2011-2015, and 2016-2020 using data extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Period analysis was used in this study to analyze the data from the SEER database and to assess survival differences according to age, sex, race, and socioeconomic status (SES) during the 15-year study period by comparing Kaplan-Meier curves.

Results

During 2001-2015, the 5-year RSR of patients with ccRCC increased from 78.4% to 83.0%, and the generalized linear model predicted that the 5-year RSR increased to 85.7% during 2016-2020. The RSR of patients with ccRCC differed significantly with SES, race, sex, and age. Compared with male patients, the survival advantage of female patients decreased as their age increased. The RSR of all patients with ccRCC was also lower in patients with a lower SES and of black race.

Conclusion

This study found an improvement in the RSR of patients with ccRCC during 2001-2020. Understanding the change trend of the survival rate of patients with ccRCC is helpful to improve the design of clinical trials. It also provides basic data and a scientific basis for evaluating the harm of ccRCC on the health of affected patients and the effect of cancer prevention, and developing cancer prevention plans.
Sexual Violence Among Sorority Women: Victimization Experiences, Contexts, and Disclosure
Authors: Hoxmeier Jill C. , O’Connor Julia , McMahon Sarah
Published: August 2022

The purpose of this study was to examine and compare sexual violence (SV) victimization among sorority women and unaffiliated counterparts. Results showed sorority women were more likely than unaffiliated women to report experiencing some types of SV, consuming alcohol prior to victimization, and to identify their perpetrator as a hookup/casual partner. More women, regardless of affiliation, informally disclosed their victimization compared to formally reporting; many did not tell anyone because they did not think it was serious enough. The findings point to implications for harm reduction, bystander intervention, and primary prevention programming, as well as institutional policy to address SV.
Māori experiences of hospital care: a qualitative systematic review
Authors: Thomas Courtney , Weller Jennifer , Rahiri Jamie-Lee , Harwood Matire , Pitama Suzanne
Published: August 2022

Indigenous experiences of hospitalisation may contribute to maintenance of Indigenous health inequities. We undertook a qualitative systematic review of Māori experiences of hospital care within New Zealand. We performed electronic database searches and used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement to assist study selection. We were guided by Kaupapa Māori (Māori centred) research methodology and used the CONSolIDated critERtia statement to evaluate completeness of reporting against recommended Indigenous ethical guidelines. The Betancourt framework for addressing ethnic disparities in health care was utilised to synthesise findings. Seven studies were included. Studies enlisting Indigenous research expertise and Kaupapa Māori research methodology demonstrated clearer links between participant voices and critique of hospital experiences. Multiple barriers were identified within clinical, organisational and structural loci of practice. Proposed interventions focused on building cultural safety against these barriers. Strategies promoting access to care for Māori and cultural safety training for the workforce are needed.
Effectiveness of 3 Polyherbal Formulations (EcXaPu, EcXa, and EcPu) on the Management of Oxidative Stress and Hyperglycemia
Authors: Essola Nadine Ndoe , Takuissu Guy Roussel Nguemto , Fonkoua Martin , Youovop Fotso Janvier Aimé , Mandob Damaris , Ngondi Judith Laure , Gouado Innocent
Published: August 2022

Oxidative stress and hyperglycemia are major disorders involved in the occurrence and severity not only of chronic non-communicable diseases but also of infectious pathologies. This study aimed to evaluate the in vitro antioxidant and antihyperglycemic properties of EcXaPu, EcXa, and EcPu. The antioxidant properties were evaluated using 3 mechanisms: radical scavenging; reducing property, and metal chelating. Finally, the antihyperglycemic properties were evaluated by 2 mechanisms: glucose adsorption and cellular glucose capture. The different formulations showed their ability to scavenge DPPH, ABTS, and NO radicals with SC50 ranging from 2.75 to 3.51 mg/ml, from 2.6 to 2.76 mg/ml, and from 2.59 to 3.3 mg/ml, respectively. All the formulations also reduced MoO42+ and Fe3+ and chelated Cu2+ and Fe2+. The different formulations adsorbed the glucose with glucose adsorption rates ranging from 72.83% to 87.01%. The different formulations also stimulated cellular glucose uptake, with uptake rates ranging from 31.9% to 50.71% in yeast cells and from 21.81% to 39.45% in muscle cells. These formulations could be potential agents to prevent and/or protect against biological disorders associated with oxidative stress and hyperglycemia.
Royal London Space Planning as a learning tool for postgraduate Orthodontic students. A mixed methods study
Authors: Ahmed Farooq , Sharma Pratik K
Published: August 2022

Objective:

To assess the effectiveness of the Royal London Space Planning (RLSP) as a learning tool among postgraduate orthodontic students as well as investigate students’ attitudes to its use. The RLSP tool is a structured method of orthodontic case assessment and treatment planning.

Design:

A prospective cohort study of first year postgraduate orthodontic students who attended teaching of the RLSP.

Setting:

Postgraduate teaching institute.

Participants:

First year postgraduate orthodontic students.

Methods:

The outcome measured was the accuracy in assessment and planning of a standardised orthodontic simulated case before and after teaching. Qualitative assessment was conducted through focus group and a semi-structured format after the teaching.

Results:

Nineteen students were included in the study. There was an overall improvement in assessment and planning of 20% after the teaching intervention ( P < 0.05). Assessment improved by 34% in comparison to treatment planning, which improved by 17% ( P < 0.05). The impact of the RLSP was most noticeable on the assessment of crowding in the lower arch which improved by 37% after teaching ( P < 0.05). Students felt using the RLSP tool made them more confident and was advantageous to use in training; most felt they would not use the tool after qualification.

Conclusion:

The RLSP tool is an effective method of teaching assessment and treatment planning to postgraduate orthodontic students. The effect of the RLSP is greater at assessments and less significant for treatment planning. The participant students felt the RLSP improved their confidence in assessment and treatment planning.
Closure of Post-thrombotic Iliac Arteriovenous Fistulas by Iliac Vein Recanalization
Authors: Schlager Oliver , Wolf Florian , Mueller Markus , Gschwandtner Michael E. , Loewe Christian , Koppensteiner Renate , Beitzke Dietrich , Willfort-Ehringer Andrea
Published: August 2022

Purpose:

The purpose of this study was to report the closure of iliac arteriovenous fistulas associated with a post-thrombotic iliac vein occlusion by iliac venous stent recanalization.

Case Report:

An 80-year-old woman presented with a worsening painful swelling of her left leg after an iliofemoral deep vein thrombosis 6 months ago. Duplex ultrasound and magnetic resonance venography revealed a post-thrombotic obstruction of her iliac veins as well as several arteriovenous fistulas between branches of her left external and internal iliac arteries and adjacent diseased venous segments. In a first attempt, coil embolization did not sustainably close these iliac arteriovenous fistulas. Direct stent recanalization of the chronically diseased iliofemoral venous segment, however, resulted in an immediate closure of arteriovenous shunt flow and subsequent improvement of clinical symptoms. Six months after iliac vein stent recanalization, still no fistulas could be detected any more, venous stents were fully patent, and the patient was free of symptoms.

Conclusion:

Post-thrombotic iliofemoral obstructions might be associated with the development of arteriovenous fistulas. Direct stent recanalization of the chronically occluded veins results in closure of related arteriovenous fistulas.

Clinical Impact

This case suggests that the combined occurrence of post-thrombotic venous obstructions with arteriovenous fistulas, which are related to aforementioned venous lesions, should be evaluated for primary venous stent recanalization rather than fistula embolization.
You Booze, You Lose? Spillovers to Crime from Alcohol Sales at College Football Games
Authors: Fone Zachary S.
Published: August 2022

In recent years, many schools have lifted their alcohol sales bans at college football games, possibly as a tool to increase attendance and revenues. However, spillovers to crime deserve consideration, given the research that links alcohol consumption and availability to crime. Alcohol sales may spill over to crime through their impacts on attendance, preferences for alcohol consumption among fans, and endogenous changes to policing and enforcement, although the net effect on crime is theoretically ambiguous. Using data from the National Incident-Based Reporting System (NIBRS) over the 2005 to 2016 period for law enforcement agencies that serve 33 Football Bowl Subdivision (FBS) schools, and utilizing difference-in-differences (DD) and triple-differences empirical strategies (leveraging variation in pre-vs. post-sales periods, home vs. away game days, and sales-adopting vs. non-adopting schools), I find that alcohol sales are associated with reductions in arrests for liquor law violations (83.5 percent) and disorderly conduct (81.0 percent) on home game days.
Tunisian Horehound (Marrubium vulgare) Aqueous Extract Improves Treatment of Bleomycin-Induced Lung Fibrosis in Rat
Authors: Abidi Anouar , Dhaouafi Jihen , Brinsi Chirine , Tounsi Haifa , Sebai Hichem
Published: August 2022

Pulmonary fibrosis (PF) remains one of the most serious pneumopathies whose diagnosis and physiopathogenesis are still poorly understood and no treatment has been shown to be effective. Recently, many studies have shown a renewed interest in plants thanks to their pharmacological potentials, like horehound, known, for its anti-inflammatory and antioxidant activities. The present study investigated the effects of the aqueous extract of horehound (Mae) on bleomycin (BLM)-induced PF in rats. Thirty rats were divided into three groups. The control group received no treatment, the BLM group received only intratracheally BLM (2 mg/kg), and the Mae group underwent administration of BLM+ Mae (2 mL/kg) daily for 20 days. Obtained results showed that Mae, rich in polyphenols, could significantly improve the damage caused by BLM by reducing the inflammatory index and the fibrosis score, bringing the lung structure of fibrotic rats close to that of control rats. As well, Mae obviously acted on the BLM inflammatory reaction, and the counting of bronchoalveolar lavage fluid (Balf) cells showed an increase in total cell number and a decrease in the infiltration of inflammatory cells in the bronchoalveolar space. In addition, the BLM instillation was accompanied by oxidative stress in the lung, liver, and kidney tissues, proven by an increase in lipid peroxidation, as well as through depletion of superoxide dismutase (SOD) and catalase (CAT). The Mae treatment reversed all disturbances of BLM-induced oxidative stress parameters promoting antioxidant and anti-inflammatory of the latter. These findings point to Mae as a promising candidate for the treatment of pulmonary fibrosis.
Wise Exertion: Associating Stoic Thought with Stress, Well-Being, and Life Satisfaction in Physicians
Authors: Shreffler Jacob , Shreffler Megan , Thomas Alyssa , Huecker Martin
Published: August 2022

Recognition of how physicians contemplate and approach their activities, positive or negative, may shed light into a more holistic depiction of physician well-being. The purpose of this work was to develop items to measure wise cognitive exertion, constructed with Stoic thought, and determine its association with physician stress, well-being, and life satisfaction. A survey was sent to physicians and university staff members. This pilot investigation found a relationship among focusing on a purposeful life, acknowledging locus of control, avoiding wasteful cognition, and taking (good or bad) life experiences for personal growth and superior life satisfaction, well-being and lower stress. A 13-Item Wise Exertion Scale was developed and had significant associations with stress, well-being, and life satisfaction. Each of the four factors from the 13-Item Wise Exertion Scale were significantly associated with each measure with the exception of Control Consciousness and life satisfaction. Within physicians (N = 59), the 13-Item Wise Exertion Scale was a significant predictor, after adjusting for demographics with stress, well-being, and life satisfaction. Physicians had significantly lower 13-Item Wise Exertion Scale scores compared to non-physicians (N = 126). Future inquiries are required to determine if physicians with a mindset assembled with these beliefs have superior well-being.
Evaluating the concordance of functional MRI-based language lateralization and Wada testing in epilepsy patients: A single-center analysis
Authors: Campbell Justin M , Kundu Bornali , Lee James N , Miranda Michelle , Arain Amir , Taussky Philipp , Grandhi Ramesh , Rolston John D
Published: August 2022

Background

For patients with drug-resistant epilepsy, surgery may be effective in controlling their disease. Surgical evaluation may involve localization of the language areas using functional magnetic resonance imaging (fMRI) or Wada testing. We evaluated the accuracy of task-based fMRI versus Wada-based language lateralization in a cohort of our epilepsy patients.

Methods

In a single-center, retrospective analysis, we identified patients with medically intractable epilepsy who participated in presurgical language mapping (n = 35) with fMRI and Wada testing. Demographic variables and imaging metrics were obtained. We calculated the laterality index (LI) from task-evoked fMRI activation maps across language areas during auditory and reading tasks to determine lateralization. Possible scores for LI range from −1 (strongly left-hemisphere dominant) to 1 (strongly right-hemisphere dominant). Concordance between fMRI and Wada was estimated using Cohen’s Kappa coefficient. Association between the LI scores from the auditory and reading tasks was tested using Spearman’s rank correlation coefficient.

Results

The fMRI-based laterality indices were concordant with results from Wada testing in 91.4% of patients during the reading task ( κ = .55) and 96.9% of patients during the auditory task ( κ = .79). The mean LIs for the reading and auditory tasks were −0.52 ± 0.43 and −0.68 ± 0.42, respectively. The LI scores for the language and reading tasks were strongly correlated, r(30) = 0.57 ( p = 0.001).

Conclusion

Our findings suggest that fMRI is generally an accurate, low-risk alternative to Wada testing for language lateralization. However, when fMRI indicates atypical language lateralization (e.g., bilateral dominance), patients may benefit from subsequent Wada testing or intraoperative language mapping.
Studying Socioeconomic Status: Conceptual Problems and an Alternative Path Forward
Authors: Antonoplis Stephen
Published: August 2022

Socioeconomic status (SES; or social class) is considered an important determinant of psychological and life outcomes. Despite this importance, how to appropriately conceive of and measure it remains unsettled. In this article, I argue that SES is, under conventional conceptions of the construct, an unmeasurable construct and present an alternative strategy for studying socioeconomic conditions. I make this argument using several lines of analysis. First, a literature review of 20 years of psychological research on SES reveals that psychologists rarely define SES theoretically (79.6% of articles did not) but call a great number of operationalizations measures of SES (147 in total). Second, current recommendations for studying SES permit contradictory predictions, rendering the recommendations unsatisfactory. Third, the appropriate measurement model for SES inhibits accumulation of results across studies, which makes studying the construct practically impossible. To rectify these issues, I reconceptualize SES as a set of socioeconomic conditions and develop a measurement strategy for studying these conditions. I conclude by considering implications for ongoing research on socioeconomic conditions and for interpreting past research on SES.
Investigating the biomechanical validity of the V-spine angle technique in cricket fast bowling
Authors: Ferdinands René ED , Singh Utkarsh
Published: August 2022

The effective utilisation of braking ground reaction forces is considered an essential biomechanical characteristic of fast bowling in cricket. The configuration of the trunk and legs during the delivery stride phase has been hypothesised to increase braking forces, causing the upper body segments to increase their angular momentum and thereby increase ball release speed. This study investigated the relationship between V-spine angle, front shank angle (plant angle) and front knee angle with braking ground reaction forces and ball release speed. Three-dimensional kinematic and kinetic analyses were performed for 17 male pace bowlers (17.2 ± 1.7 years) of New South Wales grade club level using data from a Cortex 2.0 motion analysis system (200 Hz) and Kistler force plates (1000 Hz). V-spine angle was strongly and significantly correlated with braking ground reaction force (r = −0.691), plant angle (r = −0.806) and front knee angle (r = −0.606). In addition, stepwise multiple linear regression analysis revealed that front shank angle was the strongest predictor of braking ground reaction force. The data suggests that V-spine angle and plant angle may play an important role in generating high braking ground reaction forces in bowling, with the front knee angle possibly playing a supporting role. Coaches may need to consider these findings when assessing the techniques of pace bowlers.
Memory, remembrance and nostalgia in Ken Burns’ The Vietnam War
Authors: Cornelius Paul , Rhein Douglas
Published: August 2022

This essay examines how society and culture constructs differing responses to memory and remembrance in producing documentary series that look back at the American War in Indochina. Drawing upon studies of memory, nostalgia, and remembrance, the primary focus is on the recent documentary series directed by Ken Burns and Lynn Novick, The Vietnam War. That series can be seen as a remembrance rather than an example of historical memory. The essay provides a close analysis, therefore, of The Vietnam War and compares it, in particular, to an earlier series, Vietnam: The Ten Thousand Day War. Also under discussion are documentaries contemporary with the war, In the Year of the Pig and Hearts and Minds. What ultimately can be seen is a shift from active memory and advocacy in human behavior and perspective within the contemporaneous documentaries to an institutionalized construct focusing on remembrance and nostalgia in The Vietnam War.
Safeguarding children
Authors: Gibson Jeremy C.
Published: August 2022

GPs are ideally placed to identify and respond to concerns raised about children in relation to safeguarding. The most recent edition of the intercollegiate document, ‘Safeguarding Children and Young People: Roles and Competencies for Healthcare Staff, Fourth edition: January 2019’, outlines the core competencies, knowledge, skills, attitudes, and values required of GPs in the area of safeguarding children. This paper attempts to summarise its recommendations under clear headings to give GPs practical guidance for their role in safeguarding children.
Factors predicting kindergarten teachers’ integration of science into their teaching in indigenous areas
Authors: Hsin Ching-Ting , Wu Hsin-Kai , Liang Jyh-Chong , Luu Di Tam
Published: August 2022

Past studies have shown that kindergarten teachers find it challenging to integrate science into their instruction, but little is understood about factors that influence their science teaching in Indigenous areas. Our study aimed to investigate the associations between kindergarten teachers’ experiences, attitudes, self-efficacy, outcome expectations and science teaching. Partial least square structural equation modelling was employed to analyse 384 questionnaires from kindergarten teachers in Indigenous areas of Taiwan, teaching children aged 2–6 years. Results showed that self-efficacy had stronger predictive power over outcome expectations for the level of teachers’ science integration into teaching. Teachers’ mastery experience, perceived social support and attitude toward teaching diverse children significantly and positively predicted their science teaching self-efficacy and outcome expectations for Indigenous students. Moreover, teachers’ attitude toward diverse groups was significantly associated with their outcome expectations. This study sheds light on ways to enhance teachers’ early science teaching for culturally diverse students.
Interaction Mechanism of Mangiferin and Ovalbumin Based on Spectrofluorimetry and Molecular Docking
Authors: Chen Si , Zhen Shiyu
Published: August 2022

Mangiferin (MAG) is a kind of polyphenol with many bioactivities. However, its application in medicines and functional foods is restricted because of its poor aqueous solubility and stability. The construction of a MAG/protein complex is an effective way to solve this bottleneck. In this study, the interaction of MAG and ovalbumin (OVA) was systematically investigated by spectrofluorimetry, and their binding mode was clarified based on molecular docking. The results suggested that MAG could cause the static fluorescence quenching of OVA with the quenching constant ( Kq) of >2 × 1010 L/(mol·s). Their binding performance increased with increasing temperature, and the binding-site number ( n) was close to 1. The thermodynamic analysis indicated that the binding was a spontaneous process, which was mainly driven by hydrophobic force. During this process, there was no apparent change in the microenvironment surrounding the tyrosine and tryptophan residues of OVA. The molecular docking results demonstrated the hydrophobic interaction and hydrogen bonding in the complex, which well-confirmed the results of the fluorescence experiments.
A Cryoprotectant-Gel Composite Designed to Preserve Articular Cartilage during Frozen Osteoarticular Autograft Reconstruction for Malignant Bone Tumors: An Animal-Based Study
Authors: Chen Chao-Ming , Chen Yi-Chun , Wang Jir-You , Chen Cheng-Fong , Chao Kuang-Yu , Wu Po-Kuei , Chen Wei-Ming
Published: August 2022

Objective

We designed a highly adhesive cryoprotectant-gel composite (CGC), based on regular liquid-form cryoprotectant base (CB), aiming to protect cartilage tissue during frozen osteoarticular autograft reconstruction for high-grade sarcoma around the joint. This study aimed to evaluate its effectiveness in rat and porcine distal femur models.

Design

Fresh articular cartilage samples harvested from distal rat and porcine femurs were divided into 4 test groups: untreated control group, liquid nitrogen (LN) freezing group, LN freezing group pretreated with CB (CB group), and LN freezing group pretreated with CGC (CGC group). Microscopic and macroscopic evaluation of cartilage condition, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, and apoptotic protein analysis of chondrocytes were performed to confirm our results.

Results

In the rat model, CGC could prevent articular cartilage from roughness and preserve more proteoglycans when compared with the LN freezing and CB groups. Western blot analysis showed CGC could prevent cartilage from LN-induced apoptosis supported by caspase-3/8 apoptotic signaling cascade. Macroscopically, we observed CGC could reduce both articular clefting and loss of articular luminance after freezing in the porcine model. In both models, CGC could reduce articular chondrocytes from degeneration. Fewer TUNEL-positive apoptotic and more viable chondrocytes in cartilage tissue were observed in the CGC group in our animal models.

Conclusion

Our study proved that CGC could effectively prevent cartilage surface and chondrocytes from cryoinjury after LN freezing. Freezing articular cartilage surrounded with high concentration of CGC can be a better alternative to preserve articular cartilage during limb salvage surgery for malignant bone tumor.
Feline eosinophilic sclerosing fibroplasia – a characteristic inflammatory response in sites beyond the gastrointestinal tract: case report and proposed nomenclature
Authors: Zampieri Bianca , Church Molly E , Walsh Koranda , Lennon Elizabeth M
Published: August 2022

Case summary

An adult male neutered Russian Blue cat presented for a right-sided nasal mass with bilateral retropharyngeal and right mandibular lymphadenomegaly. Medial retropharyngeal lymph node excision with nasal mass biopsy revealed eosinophilic sclerosing lymphadenitis and eosinophilic and lymphoplasmacytic rhinitis, respectively. Bacterial culture of the lymph node grew Pseudomonas aeruginosa, and treatment with pradofloxacin was started. Despite initial improvement, clinical signs recurred after 9 months, and fine-needle aspirates of the right mandibular and left medial retropharyngeal lymph nodes showed eosinophilic and mastocytic infiltration. Bacterial culture of the left medial retropharyngeal lymph node grew P aeruginosa, and treatment with anti-inflammatory doses of prednisolone and, later, marbofloxacin was instituted.

Relevance and novel information

This report describes a case of feline eosinophilic sclerosing lymphadenitis diagnosed outside of the abdominal cavity and is the first case reported to be associated with P aeruginosa. Feline eosinophilic sclerosing lymphadenitis should be considered as a differential for lymphadenopathy occurring in areas other than the abdominal cavity. Feline eosinophilic sclerosing lymphadenitis may develop in cats due to a species-specific inflammatory response to chronic bacterial and fungal infections.
Social Media Networking Sites Usage and Depression Among University Students During the COVID-19 Pandemic: The Mediating Roles of Social Anxiety and Loneliness
Authors: Iqbal Javed , Asghar Muhammad Zaheer , Ashraf Muhammad Azeem , Rafiq Muhammad
Published: August 2022

The current COVID-19 pandemic has resulted in increased psychological issues such as excessive social media networking sites usage (SMNSU), loneliness, social anxiety, and depression. In this quantitative study, we examined how SMNSU can directly and indirectly influence depression, with loneliness and social anxiety examined as mediator variables. A 39-item questionnaire was used to collect survey data on SMNSU, loneliness, social anxiety, and depression from 244 blended learning undergraduate students from universities in the Hunan province in China. Partial least squares structural equation modeling was conducted using SmartPLS 3.3.3 to measure the relationships between the stated variables of interest. Results indicated that SMNSU has a direct, significant, and positive relationship with depression. In terms of mediating effects, both loneliness and social anxiety have an intervening role in the association between SMNSU and depression. This study focused on the higher education sector of China by recruiting students who were enrolled in blended learning courses during the COVID-19 pandemic and experiencing psychological problems. We found that excessive SMNSU is associated with depression. Loneliness and social anxiety also increase depression along with excessive SMNSU among blended learning students during unprecedented situations, in this case, the COVID-19 pandemic. The valuable implications of these findings for teachers, counselors, and university managers are discussed, along with a consideration of future research directions.
Implementing Health Related Social Needs Screening in an Outpatient Clinic
Authors: Nohria Raman , Xiao Nan , Guardado Rubeen , Drainoni Mari-Lynn , Smith Cara , Nokes Keith , Byhoff Elena
Published: August 2022

Introduction/Objectives:

Health-related social needs (HRSN) screening efforts have reported high rates of identified social needs. Little is known if efforts to conduct HRSN screening in resource-constrained federally-qualified health centers (FQHC) successfully captures a representative patient population.

Methods:

This cross-sectional study extracted EMR data from 2016 to 2020 for 4731 screened patients from 7 affiliated clinics of a FQHC. Unscreened patients were pulled as a random sample from the study period. A multivariable logistic regression was used to identify sociodemographic traits, chronic disease diagnoses and burden, and clinic visit type and frequency associated with being screened for HRSN.

Results:

Our FQHC screened 4731 unique patients or <1% of the total clinic population. Screened patients had a median of 3.3 (±2.5) unmet HRSN. Medicaid patients had higher odds of being screened (aOR = 1.38, CI 1.19-1.61) relative to Medicare patients. The odds of being screened for social needs increased with more provider visits per year: compared to fewer than 1 visit per year, patients with 1 to 3 provider visits (aOR = 2.06, CI 1.73-2.32), 4 to 6 provider visits (aOR = 3.34, CI 2.89-3.87), and more than 6 provider visits (aOR = 5.16, CI 4.35-6.12) all had higher odds of social needs screening. Patients with a higher comorbid disease burden (>2 conditions, aOR = 2.80, CI 2.07-3.79) had higher odds of screening.

Conclusions:

Our findings demonstrate an increased likelihood to screen patients who visit outpatient services more often and have a higher comorbid disease burden. To meet state-level Medicaid requirements, resource-constrained FQHCs that implement clinic wide HRSN screening may be well served to identify a priori strategies to ensure representative and equitable screening across the patient population.
The Influence of University Principal Preparation Program Policies on the Program Internship
Authors: Abdelrahman Nahed , Irby Beverly J. , Lara-Alecio Rafael , Tong Fuhui
Published: August 2022

The purpose of this study was to examine the influence of program admission requirements, university-district partnerships, and course content integration on the internship within principal preparation programs. University principal preparation programs have been a focus of recent attention, specifically since 2005 when the report Arthur Levine published his report, Educating School Leaders. Research identified the field-based internship as a valuable part of principal preparation programs. We developed the Principal Preparation Program Policy Survey (4Ps) to collect data from program chairs of public universities across the nation. We employed structural equation modeling to answer the research questions. The findings revealed that partnership policies have significant relationships with the principal internship and with admission requirements. Universities that develop strong district partnership policies are more likely to have strong internship and admission policies for their preparation programs. Similarly, admission policies have a significant relationship with program-course content integration, which means that the universities that produce strong admission policies are more likely to produce strong program course-content integration policies. Because this study provides empirical evidence that universitydistrict partnership policies and admissions policies have a significant relationship with internship policies, it is important for university principal preparation faculty to review their university-district partnership and admission policies and practices in relation to their internship policies and practices. The outcome based on the results implies that the stronger the university-district partnerships and admissions policies are, the stronger the internship will be.
Examination of ADHD Symptom Severity, Depression Symptoms, and Alcohol-Related Negative Consequences in College Students with ADHD
Authors: Kaiser Ariela J. E. , Shippen Nellie A. , Oddo Lauren E. , Vasko John M. , Chronis-Tuscano Andrea , Meinzer Michael C.
Published: August 2022

College students with ADHD are at elevated risk for problem drinking behaviors and depression symptoms relative to their peers without ADHD. However, mechanisms underlying these constructs are unclear. This cross-sectional study examines two models: (1) alcohol-related negative consequences account for the covariation between ADHD symptom severity and depression symptoms and (2) depression symptoms account for the covariation between ADHD symptom severity and alcohol-related negative consequences. The sample included 106 college student drinkers with ADHD ( Mage = 19.86, SD = 1.4). Results indicated that depression symptoms partially accounted for the covariation between ADHD symptom severity and alcohol-related negative consequences. Additionally, alcohol-related negative consequences partially accounted for the covariation between ADHD symptom severity and depression symptoms. Future directions and clinical implications are discussed such as understanding the bidirectional nature of these relationships longitudinally, improving alcohol and depression-related outcomes, and developing transdiagnostic treatments to address these comorbidities among young adults with ADHD.
Personality (Dys)Function and General Instability
Authors: Ringwald Whitney R. , Hallquist Michael N. , Dombrovski Alexandre Y. , Wright Aidan G. C.
Published: August 2022

Humans adapt to a dynamic environment while maintaining psychological equilibrium. Systems theories of personality hold that generalized processes control stability by regulating how strongly a person reacts to various situations. Research shows there are higher order traits of general personality function (stability) and dysfunction (general personality pathology [GPP]), but whether they capture individual differences in reactivity is largely theoretical. We tested this hypothesis by examining how general personality functioning manifests in everyday life in two samples ( Ns = 205 and 342 participants and 24,920 and 17,761 observations) that completed an ambulatory assessment protocol. Consistent with systems theories, we found that (a) there is a general factor reflecting reactivity across major domains of functioning and (b) reactivity is strongly associated with stability and GPP. Results provide insight into how people fundamentally adapt to their environments (or not) and lay the foundation for more practical, empirical models of human functioning.
Lymphaticovenous Anastomosis and Vascularized Lymph Node Transfer for the Treatment of Lymphedema—A Canadian Case Series
Authors: Bonapace-Potvin Michelle , Lorange Elisabeth , Tremblay-Champagne Marie-Pascale
Published: August 2022

Introduction: Lymphedema is a chronic and debilitating condition. This study aims to assess the efficacy and safety of lymphaticovenous anastomosis (LVA) and vascularized lymph node transfers (VLNT) for the treatment of patients suffering from lymphedema, mainly by comparing pre- and postoperative daily compression use, limb volumes, and occurrence of cellulitis. Methods: We performed a retrospective analysis of patients who were treated by a single surgeon for lymphedema with LVA and/or VLNT between March 2018 and February 2020. Eighteen limbs met the inclusion criteria. The severity of lymphatic dysfunction was assessed by indocyanine green lymphangiography. Patients with patent vessels were offered LVA, whereas those without were offered VLNT. Pre- and postoperative circumferential limb measurements, use of compression garments, and postoperative complications were compared. Results: Nine limbs underwent LVA, 8 underwent VLNT, and one both. The minimum follow-up was 12 months. Postoperatively, all but 3 patients (83%) were able to cease daily compression. When considering excess limb volumes, the average reduction was 58%. This reduction was achieved despite compression weaning. Forty-four percent of patients (8) reported episodes of recurrent cellulitis preoperatively, while postoperatively, only 3 of those patients (17%) experienced cellulitis, which was statistically significant ( P  =  .018). No surgical complications occurred. Conclusions: Patients with lymphedema can benefit from LVA and VLNT surgery. An important effect of surgery is decreased dependence on daily compression garments to maintain a stable and reasonable limb volume. The reduction of limb circumference after 1 year was similar to LVA and VLNT. Episodes of cellulitis were significantly lower after the intervention.
The Spirit of Critical Race Theory
Authors: Bracey Glenn E.
Published: August 2022

An underappreciated aspect of critical race theory (CRT) is its analysis of the intersection of race, law, religion, and spirituality. These topics are of concern to critical race theorists because a complete critique of U.S. law must account for how religion is embedded in the nation’s founding documents and subsequent jurisprudence. Recently, leading scholars have called for a theory that accounts for the codefining quality of race, racism, and religion. I argue that CRT is an appropriate answer to these calls. I demonstrate CRT’s utility by renewing the religion and spirituality-based critique of race law that undergirds early CRT. Then, I discuss the spirituality of CRT, noting its founders’ reliance on Christian tradition and the spiritual claims in its tenets. Finally, I suggest future lines for research and show how CRT speaks to several debates among religious practitioners and academic researchers.
GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post–allo-HSCT
Authors: Wang Dongyao , Sun Zimin , Zhu Xiaoyu , Zheng Xiaohu , Zhou Yonggang , Lu Yichen , Yan Peidong , Wang Huiru , Liu Huilan , Jin Jing , Zhu Huaiping , Sun Rui , Wang Yi , Fu Binqing , Tian Zhigang , Wei Haiming
Published: August 2022

Relapse is a leading cause of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML). However, the underlying mechanisms remain poorly understood. Natural killer (NK) cells play a crucial role in tumor surveillance and cancer immunotherapy, and NK cell dysfunction has been observed in various tumors. Here, we performed ex vivo experiments to systematically characterize the mechanisms underlying the dysfunction of bone marrow−derived NK (BMNK) cells isolated from AML patients experiencing early relapse after allo-HSCT. We demonstrated that higher levels of active transforming growth factor β1 (TGF-β1) were associated with impaired effector function of BMNK cells in these AML patients. TGF-β1 activation was induced by the overexpression of glycoprotein A repetitions predominant on the surface of CD4+ T cells. Active TGF-β1 significantly suppressed mTORC1 activity, mitochondrial oxidative phosphorylation, the proliferation, and cytotoxicity of BMNK cells. Furthermore, pretreatment with the clinical stage TGF-β1 pathway inhibitor, galunisertib, significantly restored mTORC1 activity, mitochondrial homeostasis, and cytotoxicity. Importantly, the blockade of the TGF-β1 signaling improved the antitumor activity of NK cells in a leukemia xenograft mouse model. Thus, our findings reveal a mechanism explaining BMNK cell dysfunction and suggest that targeted inhibition of TGF-β1 signaling may represent a potential therapeutic intervention to improve outcomes in AML patients undergoing allo-HSCT or NK cell−based immunotherapy.
A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis
Authors: Dampier Carlton D. , Telen Marilyn Jo , Wun Ted , Brown R. Clark , Desai Payal , El Rassi Fuad , Fuh Beng , Kanter Julie , Pastore Yves , Rothman Jennifer , Taylor James G. , Readett David , Sivamurthy Krupa M. , Tammara Brinda , Tseng Li-Jung , Lozier Jay Nelson , Thackray Helen , Magnani John L. , Hassell Kathryn L.
Published: August 2022

The efficacy and safety of rivipansel, a predominantly E-selectin antagonist, were studied in a phase 3, randomized, controlled trial for vaso-occlusive crisis (VOC) requiring hospitalization (RESET). A total of 345 subjects (204 adults and 141 children) were randomized and 320 were treated (162 with rivipansel, 158 with placebo) with an IV loading dose, followed by up to 14 additional 12-hourly maintenance doses of rivipansel or placebo, in addition to standard care. Rivipansel was similarly administered during subsequent VOCs in the Open-label Extension (OLE) study. In the full analysis population, the median time to readiness for discharge (TTRFD), the primary end point, was not different between rivipansel and placebo (−5.7 hours, P = .79; hazard ratio, 0.97), nor were differences seen in secondary end points of time to discharge (TTD), time to discontinuation of IV opioids (TTDIVO), and cumulative IV opioid use. Mean soluble E-selectin decreased 61% from baseline after the loading dose in the rivipansel group, while remaining unchanged in the placebo group. In a post hoc analysis, early rivipansel treatment within 26.4 hours of VOC pain onset (earliest quartile of time from VOC onset to treatment) reduced median TTRFD by 56.3 hours, reduced median TTD by 41.5 hours, and reduced median TTDIVO by 50.5 hours, compared with placebo (all P < .05). A similar subgroup analysis comparing OLE early-treatment with early-treatment RESET placebo showed a reduction in TTD of 23.1 hours (P = .062) and in TTDIVO of 30.1 hours (P = .087). Timing of rivipansel administration after pain onset may be critical to achieving accelerated resolution of acute VOC. Trial Registration: Clinicaltrials.gov, NCT02187003 (RESET), NCT02433158 (OLE).
A novel CD19/CD22/CD3 trispecific antibody enhances therapeutic efficacy and overcomes immune escape against B-ALL
Authors: Zhao Lijun , Li Shuhong , Wei Xiaoyi , Qi Xuexiu , Liu Dong , Liu Lei , Wen Feiqiu , Zhang Ji-shuai , Wang Feng , Liu Ze-lin , Cao Yu J.
Published: August 2022

The bispecific T-cell engager (BiTE) blinatumomab against CD19 and CD3 has emerged as the most successful bispecific antibody (bsAb) to date; however, a significant proportion of patients do not respond to the treatments or eventually experience relapse after an initial response, and the recurrence rate increases significantly due to escape or downregulation of the CD19 antigen. To enhance antitumor efficacy and overcome potential immune escape, we developed a novel approach to design a CD19/CD22/CD3 trispecific antibody (tsAb) by site-specifically fusing anti-CD19 scFv (FMC63) and anti-CD22 nanobody (Nb25) to the defined sites of the CD3 antigen-binding fragment (Fab, SP34). This strategy allows for the optimal formation of immune synapses mediated by CD19/CD22/CD3 between target cells and T cells. Optimized tsAb can be superior for inducing T-cell−specific cytotoxicity and cytokine production against CD19+ and/or CD22+ tumor cells compared to other tsAb formats, and demonstrated significantly enhanced antitumor efficacy and the ability to overcome immune escape compared with the corresponding bsAbs alone or in combination, as well as with blinatumomab. In addition, tsAb treatment can lead to the long-term elimination of primary B-ALL patient samples in the PDX model and significantly prolong survival. This novel approach provides unique insight into the structural optimization of T-cell−redirected multispecific antibodies using site-specific recombination, and may be broadly applicable to heterogeneous and resistant tumor populations as well as solid tumors.