bluuebunny/crossref_metadata_2025 huggingface dataset:
The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders
Authors: Maiuolo Jessica , Gliozzi Micaela , Musolino Vincenzo , Carresi Cristina , Scarano Federica , Nucera Saverio , Scicchitano Miriam , Oppedisano Francesca , Bosco Francesca , Ruga Stefano , Zito Maria Caterina , Macri Roberta , Palma Ernesto , Muscoli Carolina , Mollace Vincenzo
Published: March 2021

Different bacterial families colonize most mucosal tissues in the human organism such as the skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian intestine hosts a microbial community of between 1,000 and 1,500 bacterial species, collectively called “microbiota.” Co-metabolism between the microbiota and the host system is generated and the symbiotic relationship is mutually beneficial. The balance that is achieved between the microbiota and the host organism is fundamental to the organization of the immune system. Scientific studies have highlighted a direct correlation between the intestinal microbiota and the brain, establishing the existence of the gut microbiota–brain axis. Based on this theory, the microbiota acts on the development, physiology, and cognitive functions of the brain, although the mechanisms involved have not yet been fully interpreted. Similarly, a close relationship between alteration of the intestinal microbiota and the onset of several neurological pathologies has been highlighted. This review aims to point out current knowledge as can be found in literature regarding the connection between intestinal dysbiosis and the onset of particular neurological pathologies such as anxiety and depression, autism spectrum disorder, and multiple sclerosis. These disorders have always been considered to be a consequence of neuronal alteration, but in this review, we hypothesize that these alterations may be non-neuronal in origin, and consider the idea that the composition of the microbiota could be directly involved. In this direction, the following two key points will be highlighted: (1) the direct cross-talk that comes about between neurons and gut microbiota, and (2) the degree of impact of the microbiota on the brain. Could we consider the microbiota a valuable target for reducing or modulating the incidence of certain neurological diseases?
Periodic Fluctuations in the Incidence of Gastrointestinal Cancer
Authors: Rhyu Mun-Gan , Oh Jung-Hwan , Kim Tae Ho , Kim Joon-Sung , Rhyu Young A , Hong Seung-Jin
Published: March 2021

Purpose

Native stem cells can be periodically replaced during short and long epigenetic intervals. Cancer-prone new stem cells might bring about periodic (non-stochastic) carcinogenic events rather than stochastic events. We investigated the epigenetic non-stochastic carcinogenesis by analyzing regular fluctuations in lifelong cancer incidence.

Materials and Methods

Korean National Cancer Screening Program data were collected between 2009 and 2016. Non-linear and log-linear regression models were applied to comparatively evaluate non-stochastic and stochastic increases in cancer incidence. Prediction performances of regression models were measured by calculating the coefficient of determination, R2.

Results

The incidence of gastric and colorectal cancers fluctuated regularly during both short (8 years) and long (20 years) intervals in the non-linear regression model and increased stochastically in the log-linear regression model. In comparison between the 20-year interval fluctuation model and the stochastic model, R2 values were higher in the 20-year interval fluctuation model of men with gastric cancer (0.975 vs. 0.956), and in the stochastic model of men with colorectal cancer (0.862 vs. 0.877) and women with gastric cancer (0.837 vs. 0.890) and colorectal cancer (0.773 vs. 0.809). Men with gastric cancer showed a high R2 value (0.973) in the 8-year interval fluctuation model as well.

Conclusion

Lifelong incidence of gastrointestinal cancer tended to fluctuate during short and long intervals, especially in men with gastric cancer, suggesting the influence of an epigenetic schedule.
Immune-Related Adverse Events Are Associated With Clinical Benefit in Patients With Non-Small-Cell Lung Cancer Treated With Immunotherapy Plus Chemotherapy: A Retrospective Study
Authors: Morimoto Kenji , Yamada Tadaaki , Takumi Chieko , Ogura Yuri , Takeda Takayuki , Onoi Keisuke , Chihara Yusuke , Taniguchi Ryusuke , Yamada Takahiro , Hiranuma Osamu , Morimoto Yoshie , Iwasaku Masahiro , Kaneko Yoshiko , Uchino Junji , Takayama Koichi
Published: March 2021

Background

The immunotherapy plus chemotherapy combination is one of the most promising treatments in advanced non-small-cell lung cancer (NSCLC). Immunotherapy often causes immune-related adverse events (irAEs), which have been reported to be associated with the good clinical outcomes. However, the effects of immunotherapy plus chemotherapy remain unknown. In this study, we investigated the association between irAEs caused by immunotherapy plus chemotherapy and clinical efficacy in patients with advanced NSCLC.

Materials and Methods

We retrospectively analyzed the data of patients with advanced NSCLC, who received a combination of immunotherapy plus chemotherapy at six institutions in Japan between January 2019 and September 2019. We examined the effect of irAEs on various clinical outcomes.

Results

We included 70 patients with advanced NSCLC. Patients were divided into two groups: patients with irAEs and patients without irAEs. Patients with irAEs had significantly longer progression-free survival than those without irAEs on univariate (hazard ratio 0.53, 95% confidence interval 0.30–0.93, p = 0.026) and multivariate (hazard ratio 0.53, 95% confidence interval 0.29–0.97, p = 0.041) analyses. In addition, patients with grade 1–2 irAEs (mild irAEs) had significantly longer progression-free and overall survival than those with grade 3-5 irAEs (severe irAEs) or without irAEs on univariate (398 days versus 189 days, respectively; p = 0.0061) and multivariate (not reached versus 412 days, respectively; p = 0.021) analyses.

Conclusion

Patients with NSCLC who experienced mild irAEs showed better response to treatment with immunotherapy plus chemotherapy than those with severe irAEs or without irAEs. Further large-scale research is warranted to confirm these findings.
Analysis of the PD-1 Ligands Among Gastrointestinal Cancer Patients: Focus on Cancer Immunity
Authors: Dai Lin , Huang Zilin , Li Wang
Published: March 2021

Many types of gastrointestinal cancer have shown promising outcomes after checkpoint blockade immunotherapy; however, it remains largely unclear about the expression profiles of programmed death 1 (PD-1) ligands (CD274 and PDCD1LG2) in the context of human pan-cancer. This work comprehensively analyzed the expression pattern of the PD-1 ligands and the clinical significance in the prognosis prediction among the seven types of gastrointestinal malignancies collected from The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE) database. Furthermore, the correlation of CD274/PDCD1LG2 with cancer immunity was also explored. The patients with liver hepatocellular carcinoma (LIHC) receiving cytokine-induced killer (CIK) cell immunotherapy at our cancer center were enrolled. CD274 and PDCD1LG2 displayed inconsistent gene expression levels among the diverse cancer cell lines. Typically, the abnormal expression level of CD274 and PDCD1LG2 was detected in both esophageal carcinoma (ESCA) and stomach adenocarcinoma (STAD), where PDCD1LG2 was related to the overall survival (OS) of the patients in ESCA (p = 0.015) and STAD (p = 0.025). High-serum CD274 and PDCD1LG2 levels predicted a worse survival in the patients with LIHC receiving CIK therapy. More importantly, the expression level of CD274 and PDCD1LG2 was significantly correlated with the degree of Estimation of STromal and Immune cells in MAlignant Tumor tissues using the Expression data (ESTIMATE). In addition, we found that CD274 and PDCD1LG2 were correlated with gene markers in tumor-infiltrating immune cells. Furthermore, the expression of CD274 and PDCD1LG2 was correlated with tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), and DNA methyltransferase (DNMT) of different types of cancers. The present work comprehensively analyzed a RNA sequencing of the PD-1 ligands across the seven distinct types of gastrointestinal cancers, which provided clues for further studies in cancer immunity and development.
Interleukin-17 Receptor D in Physiology, Inflammation and Cancer
Authors: Girondel Charlotte , Meloche Sylvain
Published: March 2021

Interleukin-17 receptor D (IL-17RD) is an evolutionarily conserved member of the IL-17 receptor family. Originally identified as a negative regulator of fibroblast growth factor (FGF) signaling under the name of Sef (Similar expression to FGF genes), IL-17RD was subsequently reported to regulate other receptor tyrosine kinase signaling pathways. In addition, recent studies have shown that IL-17RD also modulates IL-17 and Toll-like receptor (TLR) signaling. Combined genetic and cell biology studies have implicated IL-17RD in the control of cell proliferation and differentiation, cell survival, lineage specification, and inflammation. Accumulating evidence also suggest a role for IL-17RD in tumorigenesis. Expression of IL-17RD is down-regulated in various human cancers and recent work has shown that loss of IL-17RD promotes tumor formation in mice. However, the exact mechanisms underlying the tumor suppressor function of IL-17RD remain unclear and some studies have proposed that IL-17RD may exert pro-tumorigenic effects in certain contexts. Here, we provide an overview of the signaling functions of IL-17RD and review the evidence for its involvement in cancer.
Proactive Measures to Combat a SARS-CoV-2 Transmission Among High Risk Patients and Health Care Workers in an Outpatient Dialysis Facility
Authors: Pillai Jayandiran , Motloba Pagollang , Motaung Keolebogile Shirley Caroline , Wallis Carole , Ozougwu Lovelyn Uzoma , Basu Debashis
Published: March 2021

Background: End-stage-renal-failure (ESRF) patients attending clustered out-patient dialysis are susceptible to SARS-CoV-2 infection. Comorbidities render them vulnerable to severe COVID-19. Although preventative and mitigation strategies are recommended, the effect of these are unknown. A period of “potential-high-infectivity” results if a health-care-worker (HCWs) or a patient becomes infected.

Aim: We describe and analyze early, universal SARS-CoV-2 real time reverse transcription polymerase chain reaction (RT-PCR) tests, biomarker monitoring and SARS-CoV-2 preventative strategies, in a single dialysis center, after a positive patient was identified.

Methodology: The setting was a single outpatient dialysis center in Johannesburg, South Africa which had already implemented preventative strategies. We describe the management of 57 patients and 11 HCWs, after one of the patients tested positive for SARS-CoV-2. All individuals were subjected to RT-PCR tests and biomarkers (Neutrophil-Lymphocyte Ratio, C-reactive protein, and D-Dimer) within 72 h (initial-tests). Individuals with initial negative RT-PCR and abnormal biomarkers (one or more) were subjected to repeat RT-PCR and biomarkers (retest subgroup) during the second week. Additional stringent measures (awareness of viral transmission, dialysis distancing and screening) were implemented during the period of “potential high infectivity.” The patient retest subgroup also underwent clustered dialysis until retest results became available.

Results: A second positive-patient was identified as a result of early universal RT-PCR tests. In the two positive-patients, biomarker improvement coincided with RT-PCR negative tests. We identified 13 individuals for retesting. None of these retested individuals tested positive for SARS-CoV-2 and there was no deterioration in median biomarker values between initial and retests. Collectively, none of the negative individuals developed COVID-19 symptoms during the period “potential high infectivity.”

Conclusion: A SARS-CoV-2 outbreak may necessitate additional proactive steps to counteract spread of infection. This includes early universal RT-PCR testing and creating further awareness of the risk of transmission and modifying preventative strategies. Abnormal biomarkers may be poorly predictive of SARS-CoV-2 infection in ESRF patients due to underlying illnesses. Observing dynamic changes in biomarkers in RT-PCR positive and negative-patients may provide insights into general state of health.
Comparative Effectiveness of Midazolam, Propofol, and Dexmedetomidine in Patients With or at Risk for Acute Respiratory Distress Syndrome: A Propensity Score-Matched Cohort Study
Authors: Hu An-Min , Zhong Xiong-Xiong , Li Zhen , Zhang Zhong-Jun , Li Hui-Ping
Published: March 2021

Background: Sedatives are commonly used in patients with or at risk for acute respiratory distress syndrome (ARDS) during mechanical ventilation. To systematically compare the outcomes of sedation with midazolam, propofol, and dexmedetomidine in patients with or at risk for ARDS.

Methods: We developed a dataset of real-world data to enable the comparison of the effectiveness and safety of sedatives and the associated outcomes from the MIMIC-III database and the eICU Collaborative Research database. We performed a systematic study with six cohorts to estimate the relative risks of outcomes among patients administered different sedatives. Propensity score matching was performed to generate a balanced 1:1 matched cohort and to identify potential prognostic factors. The outcomes included hospital mortality, duration of mechanical ventilation, length of intensive care unit stay, length of hospitalization, and likelihood of being discharged home.

Results: We performed 60 calibrated analyses among all groups and outcomes with 17,410 eligible patients. Sedation with dexmedetomidine was associated with a lower in-hospital mortality rate than sedation with midazolam and propofol or sedation without dexmedetomidine (p < 0.001). When compared with no sedation, the use of midazolam, propofol or dexmedetomidine was associated with a longer ICU stay and longer hospitalization duration (p < 0.01). Patients treated with midazolam were relatively less likely to be discharged home (p < 0.05).

Conclusion: Patients treated with dexmedetomidine had a reduced risk of mortality. These data suggest that dexmedetomidine may be the preferred sedative in patients with or at risk for ARDS.
Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology
Authors: Popescu Maria , Feldman Talia B. , Chitnis Tanuja
Published: March 2021

The sex-bias of disease susceptibility has remained a puzzling aspect of several autoimmune conditions, including post-infection viral autoimmunity. In the last half of the twentieth century, the incidence rate of female-biased autoimmunity has steadily increased independent of medical advances. This has suggested a role for environmental factors, such as endocrine disrupting chemicals, which have been described to interfere with endocrine signaling. Endocrine involvement in the proper function of innate and adaptive immunity has also been defined, however, these two areas have rarely been reviewed in correlation. In addition, studies addressing the effects of endocrine disruptors have reported findings resulting from a broad range of exposure doses, schedules and models. This experimental heterogeneity adds confusion and may mislead the translation of findings to human health. Our work will normalize results across experiments and provide a necessary summary relevant to human exposure. Through a novel approach, we describe how different categories of ubiquitously used environmental endocrine disruptors interfere with immune relevant endocrine signaling and contribute to autoimmunity. We hope this review will guide identification of mechanisms and concentration-dependent EDC effects important not only for the sex-bias of autoimmunity, but also for other conditions of immune dysfunction, including post-infection autoreactivity such as may arise following severe acute respiratory syndrome coronavirus 2, Epstein-Barr virus, Herpes Simplex virus.
The Role of Relational Entitlement, Self-Disclosure and Perceived Partner Responsiveness in Predicting Couple Satisfaction: A Daily-Diary Study
Authors: Candel Octav Sorin , Turliuc Maria Nicoleta
Published: March 2021

Recent research has investigated how the sense of relational entitlement (SRE, the extent to which a person expects that his/her needs and wishes will be fulfilled by the romantic partner) diminishes couple satisfaction, but little is known about how SRE affects the daily quality of close, romantic relationships. Moreover, the evidence on how SRE interacts with other features of a satisfying relationship (such as the variables of the interpersonal process model of relationships—self-disclosure, perceived partner disclosure, and perceived partner responsiveness) is scarce. Using an electronic daily diary, we examined 99 couples (198 participants) for 7 days, with two daily measurements for each partner. We used a dyadic double intercept multilevel model, which simultaneously computes effects for men and women. We tested a model where one partner's daily couple satisfaction was predicted by their overall levels of SRE (excessive, restricted, and assertive) and by their daily and overall levels of self-disclosure, perceived partner self-disclosure, and perceived partner responsiveness. The model also included person-level interactions and cross-level interactions between the SRE types and variables of the interpersonal process model of relationships for each gender. The analysis indicated that person-level excessive SRE lowers couple satisfaction. Also, day and person-level perceived partner responsiveness and person-level self-disclosure are related to couple satisfaction, but the latter association is significant only for men. Finally, we found some significant person-level interactions that account for changes in couple satisfaction. For men, the links between couple satisfaction, excessive and restricted SRE were moderated by self-disclosure and perceived partner responsiveness, respectively, perceived partner self-disclosure and perceived partner responsiveness. For women, the associations between couple satisfaction, restricted and assertive SRE were moderated by self-disclosure, respectively, perceived partner self-disclosure. This study advances our understanding of the general implications of SRE in the dynamics of couple relationships. More specifically, it shows how SRE interacts with other couple-specific variables in shaping day-to-day couple satisfaction. The theoretical and clinical implications for couple therapy are discussed.
The Neglected C of Intercultural Relations. Cross-Cultural Adaptation Shapes Sojourner Representations of Locals
Authors: Bierwiaczonek Kinga , Waldzus Sven , Zee Karen van der
Published: March 2021

We investigated, by means of the Reverse Correlation Task (RCT), visual representations of the culturally dominating group of local people held by sojourners as a function of their degree of cross-cultural adaptation. In three studies, using three different methods (reduced RCT, full RCT, conceptual replication) with three independent samples of sojourners and seven independent samples of Portuguese and US-American raters, we gathered clear evidence that poor adaptation goes along with more negative representations of locals. This indicates that sojourner adaptation is reflected, at a social-cognitive level, in the valence of outgroup representations.
The Compensatory Protective Effects of Social Support at Work in Presenteeism During the Coronavirus Disease Pandemic
Authors: Chen Jia Wun , Lu Luo , Cooper Cary L.
Published: March 2021

The present study investigated the lasting effects of sickness presenteeism on well-being and innovative job performance in the demanding Chinese work context compounded with the precarities of the post-pandemic business environment. Adopting the conservation of resources (COR) theory perspective, especially its proposition of compensation of resources, we incorporated social resources at work (supervisory support and collegial support) as joint moderators in the presenteeism–outcomes relationship. We employed a panel design in which all variables were measured twice with 6 months in between. Data were obtained from 323 Chinese employees working in diverse industries in Taiwan. We found that after controlling for the baseline level of well-being, presenteeism did not have a lasting effect on employees' exhaustion. However, presenteeism did have a negative lasting effect on employees' innovative behavior 6 months later. Moreover, we found a significant three-way interaction of presenteeism, supervisory support, and collegial support on employees' innovative job performance, after controlling for the baseline level of performance. Specifically, when working under illness, employees displayed the best innovative performance with high levels of both supervisory and collegial support, the worst performance with both support being low, and the intermediate when any one of the support being high. This can be taken as the preliminary evidence to support the COR proposition of resource caravans, showing that supervisory support and collegial support compensated for each other as critical resources in alleviating the impact of working under sickness on employees' innovative performance. Theoretical implications of the findings are discussed, taking into account the macro-cultural context of the East Asian Confucian societies. We also reflected on the managerial implications of the lasting damages of sickness presenteeism and benefits of mobilizing social resources on employees' well-being and performance.
COVID-19: Mental Health Prevention and Care for Healthcare Professionals
Authors: Rolling Julie , Mengin Amaury C. , Palacio Cédric , Mastelli Dominique , Fath Morgane , Gras Adrien , Von Hunolstein Jean-Jacques , Schröder Carmen M. , Vidailhet Pierre
Published: March 2021

The Coronavirus Disease 2019 (COVID-19) pandemic exposed health professionals to high stress levels inducing significant psychological impact. Our region, Grand Est, was the most impacted French region during the first COVID-19 wave. In this context, we created CoviPsyHUS, local mental health prevention and care system dedicated explicitly to healthcare workers affected by the COVID-19 pandemic in one of this region's tertiary hospitals. We deployed CoviPsyHUS gradually in 1 month. To date, CoviPsyHUS comprises 60 mental health professionals dedicated to 4 complementary components: (i) a mental health support hotline (170 calls), (ii) relaxation rooms (used by 2,120 healthcare workers with 110 therapeutic workshops offered), (iii) mobile teams (1,200 contacts with healthcare staff), and (iv) a section dedicated to patients and their families. Among the critical points to integrate mental health care system during a crisis, we identified: (i) massive dissemination of mental health support information with multimodal communication, (ii) clear identification of the mental health support system, (iii) proactive mobile teams to identify healthcare professionals in difficulty, (iv) concrete measures to relieve the healthcare professionals under pressure (e.g., the relay in communication with families), (v) support for primary needs (body care (physiotherapy), advice and first-line therapy for sleep disorders), and (vi) psychoeducation and emotion management techniques. The different components of CoviPsyHUS are vital elements in meeting the needs of caregivers in situations of continuous stress. The organization of 4 targeted, modular, and rapidly deployable components makes CoviPsyHUS an innovative, reactive, and replicable mental health prevention and care system that could serve as a universal support model for other COVID-19 affected teams or other exceptional health crises in the future.
A Fear of COVID-19 and PTSD Symptoms in Pathological Personality: The Mediating Effect of Dissociation and Emotion Dysregulation
Authors: Velotti Patrizia , Civilla Claudia , Rogier Guyonne , Beomonte Zobel Sara
Published: March 2021

Background: The 2019 coronavirus disease (COVID-19) outbreak is currently putting a strain on the mental health resilience of the world's population. Specifically, it is likely to elicit an intense response to fear and to act as a risk factor for the onset of posttraumatic stress disorder (PTSD). Some individuals may be more at risk than others, with pathological personality variables being a potential candidate as a central vulnerability factor. In addition, the pathways that lead the pathological personality to PTSD and intense fear responses to COVID-19 are likely to be explained by poor emotion regulation capacities, as well as by dissociative mechanisms.

Aims: This study aimed to shed light on vulnerability factors that may account for the onset of PTSD and intense responses of fear in response to COVID-19 outbreak and to test the mediating role of emotion dysregulation and dissociation proneness in these pathways.

Methods: We used a longitudinal design of research administered to a sample of community individuals (N = 308; meanage = 35.31, SD = 13.91; 22.7% were male). Moreover, we used self-report questionnaires to measure pathological personality, emotion regulation capacities, dissociative proneness at the beginning of the lockdown, and PTSD symptoms and fear of COVID-19 at the end of the Italian lockdown (from March 9 to May 18, 2020). Structural equation modeling was used to test the hypotheses.

Results: We found that pathological personality levels longitudinally predicted PTSD and fear of COVID-19 levels. Moreover, the associations between emotion dysregulation and dissociation were shown to significantly and totally mediate the relationship between pathological personality and PTSD, whereas no significant mediation effects were observed in relation to fear of COVID-19.

Conclusions: Individuals with pathological personality traits may be more vulnerable to the onset of negative psychological consequences related to COVID-19 outbreak, such as PTSD symptomatology and fear levels. Emotion regulation capacities appear to be relevant targets of interventions for PTSD symptomatology. Future research should explore the mediating variables linking pathological personality to intense fear responses to COVID-19.
Improving Individual Brain Age Prediction Using an Ensemble Deep Learning Framework
Authors: Kuo Chen-Yuan , Tai Tsung-Ming , Lee Pei-Lin , Tseng Chiu-Wang , Chen Chieh-Yu , Chen Liang-Kung , Lee Cheng-Kuang , Chou Kun-Hsien , See Simon , Lin Ching-Po
Published: March 2021

Brain age is an imaging-based biomarker with excellent feasibility for characterizing individual brain health and may serve as a single quantitative index for clinical and domain-specific usage. Brain age has been successfully estimated using extensive neuroimaging data from healthy participants with various feature extraction and conventional machine learning (ML) approaches. Recently, several end-to-end deep learning (DL) analytical frameworks have been proposed as alternative approaches to predict individual brain age with higher accuracy. However, the optimal approach to select and assemble appropriate input feature sets for DL analytical frameworks remains to be determined. In the Predictive Analytics Competition 2019, we proposed a hierarchical analytical framework which first used ML algorithms to investigate the potential contribution of different input features for predicting individual brain age. The obtained information then served as a priori knowledge for determining the input feature sets of the final ensemble DL prediction model. Systematic evaluation revealed that ML approaches with multiple concurrent input features, including tissue volume and density, achieved higher prediction accuracy when compared with approaches with a single input feature set [Ridge regression: mean absolute error (MAE) = 4.51 years, R2 = 0.88; support vector regression, MAE = 4.42 years, R2 = 0.88]. Based on this evaluation, a final ensemble DL brain age prediction model integrating multiple feature sets was constructed with reasonable computation capacity and achieved higher prediction accuracy when compared with ML approaches in the training dataset (MAE = 3.77 years; R2 = 0.90). Furthermore, the proposed ensemble DL brain age prediction model also demonstrated sufficient generalizability in the testing dataset (MAE = 3.33 years). In summary, this study provides initial evidence of how-to efficiency for integrating ML and advanced DL approaches into a unified analytical framework for predicting individual brain age with higher accuracy. With the increase in large open multiple-modality neuroimaging datasets, ensemble DL strategies with appropriate input feature sets serve as a candidate approach for predicting individual brain age in the future.
Locating Creativity in Differing Approaches to Musical Robotics
Authors: Kemper Steven
Published: March 2021

The field of musical robotics presents an interesting case study of the intersection between creativity and robotics. While the potential for machines to express creativity represents an important issue in the field of robotics and AI, this subject is especially relevant in the case of machines that replicate human activities that are traditionally associated with creativity, such as music making. There are several different approaches that fall under the broad category of musical robotics, and creativity is expressed differently based on the design and goals of each approach. By exploring elements of anthropomorphic form, capacity for sonic nuance, control, and musical output, this article evaluates the locus of creativity in six of the most prominent approaches to musical robots, including: 1) nonspecialized anthropomorphic robots that can play musical instruments, 2) specialized anthropomorphic robots that model the physical actions of human musicians, 3) semi-anthropomorphic robotic musicians, 4) non-anthropomorphic robotic instruments, 5) cooperative musical robots, and 6) individual actuators used for their own sound production capabilities.
Relative Age Effect in 14- to 18-Year-Old Athletes and Their Initial Approach to This Effect—Has Anything Changed Over the Past 10 Years?
Authors: Lidor Ronnie , Maayan Zohar , Arnon Michal
Published: March 2021

One of the environmental variables associated with early talent development and the achievement of a high level of proficiency in sport is the relative age effect (RAE). The purpose of our study was threefold: (a) to calculate the RAE in young Israeli athletes (ages 14–18 years); (b) to examine how the athletes perceived this effect, if the effect indeed exists; and (c) to compare the RAE findings of this study with those of two previous studies on elite male (Lidor et al., 2010) and female (Lidor et al., 2014) Israeli ballplayers. Participants in the current study were 1,397 athletes (390 females and 1,007 males) who competed in five individual (gymnastics, judo, swimming, tennis, and track and field) and five team (basketball, soccer, team handball, volleyball, and water polo) sports. Data on the RAE, as well as on a number of aspects associated with this effect as perceived by the athletes, were collected via two closed questions. Data analyses showed that the RAE was found to be significant among the male athletes in four sports—swimming, basketball, soccer, and team handball; those who were born early in the year had a higher representation in these sport programs. However, this effect was not found to be significant in the female athletes. Most of the female and male athletes did not think that their birth date influenced their athletic success. However, a large portion of those who were born in the first quarter of the year (Q1) and the second quarter of the year (Q2) among the male athletes felt that they exhibited stronger abilities in the sports program compared to their peers who were born in the third and fourth quarters of the year (Q3 and Q4, respectively). The data of the current study provide additional support for the use of an “open door” approach to accepting children to sport programs by policymakers and coaches in Israel.
Selected, Deselected, and Reselected: A Case Study Analysis of Attributes Associated With Player Reselection Following Closure of a Youth Soccer Academy
Authors: Dugdale James H. , McRobert Allistair P. , Unnithan Viswanath B.
Published: March 2021

Considering the perceived benefit of early recruitment and the time and resources spent developing youth players, individuals released from talent development programmes are often re-recruited by rival academies. However, due to the contractual nature of many talent development programmes, limited empirical data exists on players deselected from (or reselected to) youth soccer academies. Adopting a novel case study approach, differences in skill, psychological, and physical attributes associated with reselection following closure of a junior-elite soccer academy were explored. Overall subjective coach ratings for skill, psychological, and physical abilities; subjective coach ratings for skill and psychological attributes; and physical fitness test performance of 79 junior-elite soccer players (U11–U17) were assessed as part of regular scheduled testing and monitoring practices prior to the academy closure. Reselection status was monitored and recorded for all players in the 6 months following the academy closure and was classified as a persistence/progression (“Reselected”) or attrition (“Deselected”) in playing level. Of the 79 released players, a total of 60 players (76%) were re-signed to a junior-elite academy within 6 months. Differences were observed for overall ratings of skill, psychological, and physical abilities in favor of the “Reselected” player group. “Reselected” players were also rated higher by coaches for all attributes categorized as skill and psychological, as well as performing better at all physical fitness tests. However, “Reselected” players were lesser in stature and body mass and less mature than “Deselected” players. Our findings suggest that reselection is not a product of anthropometric criteria and, therefore, a pathway for selection remains open for later maturing players. We also inform upon desirable qualities associated with player reselection and provide a case study approach of a unique, yet highly relevant, scenario for talent identification and development in youth soccer.
Childhood Adversity, Impulsivity, and HIV Knowledge as Predictors of Sexual Risk Outcomes in At-Risk Female Youth
Authors: Kovensky Rachel , Khurana Atika , Guyer Sally , Leve Leslie D.
Published: March 2021

Sexual risk behavior in adolescence can lead to adverse health consequences, particularly for female youth. Most interventions focus on imparting knowledge about the consequences of such behaviors, even though little research has examined whether increasing such knowledge results in desired behavioral changes. Further, individual factors such as impulsivity and childhood adversity might moderate this relationship. We examined associations between HIV knowledge and sexual risk behavior and condom use efficacy in a sample of 122 at-risk females, aged 13–18. HIV knowledge was unrelated to sexual risk behavior, but positively related to condom use efficacy. Impulsivity and childhood adversity had direct effects, with no interaction effects. Increasing HIV knowledge may play an important role in promoting proximal predictors of safer sex practices.
Effect of a Biostimulant on Bermudagrass Fall Color Retention and Spring Green-Up
Authors: De Luca Verónica , Gómez de Barreda Diego
Published: March 2021

Field research was conducted in 2017–2019 on “Princess 77” bermudagrass (Cynodon dactylon (L.) Pers.) to determine whether an amino acid based biostimulant program applied in the late season (October-November) and early season (March-April) could extend fall color retention (FCR) or hasten the spring green-up (SGU), respectively. Bermudagrass was treated with the biostimulant under five different managements: non-treated; 6 times at 5 L ha−1 weekly; 3 times at 5 L ha−1 in a 14-day interval; 6 times at 10 L ha−1 weekly; and 3 times at 10 L ha−1 in a 14-day interval. Normalized difference vegetation index (NDVI) and visual ratings (turf green color and percentage of green coverage in the subplot) were determined weekly, and turf clipping dry weight for the SGU studies. At the end of the FCR studies (2017 and 2018), there was no effect of the biostimulant; although, some isolated positive effects were detected during the experiment in 2017 on bermudagrass treated weekly at 10 L ha−1 for NDVI. However, there was a slight positive effect on SGU when this physiological process occurred slowly (year 2018) and the biostimulant was applied weekly at 10 L ha−1 (4.4 kg N ha−1), compared to another performed management and warmer years (2017 and 2019).
Oocyte Ageing in Zebrafish Danio rerio (Hamilton, 1822) and Its Consequence on the Viability and Ploidy Anomalies in the Progeny
Authors: Waghmare Swapnil Gorakh , Samarin Azadeh Mohagheghi , Franěk Roman , Pšenička Martin , Policar Tomáš , Linhart Otomar , Samarin Azin Mohagheghi
Published: March 2021

Fish egg quality can be markedly influenced by the oocyte age after ovulation. In this study, we examined the duration of oocyte ageing in the zebrafish (Danio rerio) and whether prolonged ageing is associated with the incidence of ploidy anomalies in the resulting embryos. Oocytes were incubated in vitro for 6 h post-stripping (HPS) at 26 °C and fertilized at 2-h intervals. Meanwhile, for eggs fertilized immediately after stripping, the fertilization, embryo survival, and hatching rates started at ~80%; these rates decreased to 39%, 24%, and 16%, respectively, for oocytes that had been stored for 4 h (p ˂ 0.05), and there was an almost complete loss of egg viability at 6 HPS. Furthermore, almost 90% of the embryos derived from 6-h aged oocytes died prior to hatching, and all larvae originating from 4- and 6-h aged oocytes showed malformations. The proportion of ploidy abnormal embryos was significantly greater at 4 HPS (18.5%) than at either 0 or 2 HPS (4.7% and 8.8%, respectively). The results revealed that zebrafish oocytes retained their fertilization potential for up to 2 h after stripping at 26 °C and indicated the contribution of post-ovulatory oocyte ageing in the occurrence of ploidy anomalies in the resulting embryos.
New Echinoderm-Crab Epibiotic Associations from the Coastal Barents Sea
Authors: Dvoretsky Alexander G. , Dvoretsky Vladimir G.
Published: March 2021

During diving surveys for a Russian research project that monitored introduced species, red king crabs (Paralithodes camtschaticus) were collected at a coastal site of the Barents Sea to study the structure and dynamics of this species. Sampling of the organisms colonizing the crabs was part of this research project. For the first time, the presence of relatively large specimens of the common starfish Asterias rubens as epibionts of P. camtschaticus was observed in July 2010, 2018, and 2019. In 2010 and 2019, we also found three other echinoderm species (the Atlantic sea cucumber Cucumaria frondosa, the green sea urchin Strongylocentrotus droebachiensis, and the brittle star Ophiura sarsii). These findings add to the current list of associated species on king crabs not only in the Barents Sea but also in native areas of this host. Red king crabs have been documented as predators for these echinoderm species, and our records show additional possible interactions between king crabs and echinoderms in this region. More likely, the epibiotic lifestyle allows these echinoderms to avoid predation from red king crabs. There are no potential disadvantages derived by red king crabs through their relationships with the echinoderm epibionts due to low occurrences of these associations. We suggest no negative effects for the local red king crab population and populations of other commercial species in the Barents Sea.
Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors
Authors: Gaspar Renato Simões , Sage Tanya , Little Gemma , Kriek Neline , Pula Giordano , Gibbins Jonathan M.
Published: March 2021

Background: Protein disulphide isomerase (PDI) and NADPH oxidase 1 (Nox-1) regulate platelet function and reactive oxygen species (ROS) generation, suggesting potentially interdependent roles. Increased platelet reactivity and ROS production have been correlated with cardiometabolic disease risk factors. Objectives: To establish whether PDI and Nox-1 cooperate to control platelet function. Methods: Immunofluorescence microscopy was utilised to determine expression and localisation of PDI and Nox-1. Platelet aggregation, fibrinogen binding, P-selectin exposure, spreading and calcium mobilization were measured as markers of platelet function. A cross-sectional population study (n = 136) was conducted to assess the relationship between platelet PDI and Nox-1 levels and cardiometabolic risk factors. Results: PDI and Nox-1 co-localized upon activation induced by the collagen receptor GPVI. Co-inhibition of PDI and Nox-1 led to additive inhibition of GPVI-mediated platelet aggregation, activation and calcium flux. This was confirmed in murine Nox-1−/− platelets treated with PDI inhibitor bepristat, without affecting bleeding. PDI and Nox-1 together contributed to GPVI signalling that involved the phosphorylation of p38 MAPK, p47phox, PKC and Akt. Platelet PDI and Nox-1 levels were upregulated in obesity, with platelet Nox-1 also elevated in hypertensive individuals. Conclusions: We show that PDI and Nox-1 cooperate to control platelet function and are associated with cardiometabolic risk factors.
Stoichiometric Thiol Redox Proteomics for Quantifying Cellular Responses to Perturbations
Authors: Day Nicholas J. , Gaffrey Matthew J. , Qian Wei-Jun
Published: March 2021

Post-translational modifications regulate the structure and function of proteins that can result in changes to the activity of different pathways. These include modifications altering the redox state of thiol groups on protein cysteine residues, which are sensitive to oxidative environments. While mass spectrometry has advanced the identification of protein thiol modifications and expanded our knowledge of redox-sensitive pathways, the quantitative aspect of this technique is critical for the field of redox proteomics. In this review, we describe how mass spectrometry-based redox proteomics has enabled researchers to accurately quantify the stoichiometry of reversible oxidative modifications on specific cysteine residues of proteins. We will describe advancements in the methodology that allow for the absolute quantitation of thiol modifications, as well as recent reports that have implemented this approach. We will also highlight the significance and application of such measurements and why they are informative for the field of redox biology.
Infrared Radiation Favorably Influences the Quality Characteristics of Key Lime Juice
Authors: Altemimi Ammar B. , Al-Hilphy Asaad R. S. , Abedelmaksoud Tarek Gamal , Aboud Salam A. , Badwaik Laxmikant S. , G Lakshmanan , Noore Shaba , Pratap-Singh Anubhav
Published: March 2021

The effect of infrared radiation (IR) on the physicochemical characteristics, pectin methylesterase activity (PME), hydroxymethylfurfural (HMF) content, microbiological activity, color, and sensory aspects on black lime juice was studied. IR was compared to conventional thermal heating (CTH) in batch infrared extraction pasteurizer, designed to allow both infrared and conventional heating. IR resulted in a reduction in pH and Brix values and a mild increase in titratable acidity, as compared to CTH and control. After 60 days at 5 °C, the ascorbic acid percentage was decreased by 24.90%, 29.75%, and 58.31% in the control, IR and CTH, respectively. The total amount of phenols in juice treated with IR was higher as compared to CTH and control, while there was a significant decrease in the antioxidant activity. The statistical analysis reflected significantly low (p < 0.05) activity of PME for IR samples as compared to CTH and control. The amount of Hydroxymethylfurfural (HMF) in all juice samples steadily increased during the storage at 5 °C in 60 days. The microbial content of control was 3.85 log cfu/mL after 60 days at 5 °C, while it was 2.1 log cfu/mL for IR which reflected a significant difference between the IR, CTH, and control samples. Additionally, color and sensory analysis of IR treated sample when compared to control, reflected similar attributes. Overall, IR was found to be an excellent substitute for the preservation of black lime juice as a rapid pasteurization technique with less heat exposure; wherein the nutrition and health benefits of the juice could be maintained for a minimum period of 60 days.
Balneotherapy with the Use of Radon–Sulphide Water: The Mechanisms of Therapeutic Effect
Authors: Pawlik-Sobecka Lilla , Górka-Dynysiewicz Joanna , Kuciel-Lewandowska Jadwiga
Published: March 2021

Despite its enormous therapeutic potential, spa treatment is not always properly perceived, hence the numerous attempts to assess its effectiveness. In the world literature, there are few reports on therapy using sulphur- and radon-containing therapeutic waters. In countries with a long tradition of balneotherapy, activity in this field of medicine is evident. Undoubtedly, the interest in balneotherapy results also from natural resources used in spa medicine, which, as geological and balneochemical research shows, are enormous in Poland. A particular example of the occurrence of radon–sulphide waters, rare on the European scale, is the Przerzeczyn-Zdrój health resort. The mechanism of action of therapeutic waters is not fully explored, but their effectiveness in therapy is confirmed by many authors. It is believed to be an effect of combined action of many factors, the most important of which are thermal, mechanical, and chemical.
A Single Assistive Profile Applied by a Passive Hip Flexion Device Can Reduce the Energy Cost of Walking in Older Adults
Authors: Panizzolo Fausto Antonio , Annese Eugenio , Paoli Antonio , Marcolin Giuseppe
Published: March 2021

Difficulty walking in older adults affects their independence and ability to execute daily tasks in an autonomous way, which can result in a negative effect to their health status and risk of morbidity. Very often, reduced walking speed in older adults is caused by an elevated metabolic energy cost. Passive exoskeletons have been shown to offer a promising solution for lowering the energy cost of walking, and their simplicity could favor their use in real world settings. The goal of this study was to assess if a constant and consistent low torque applied by means of a passive exoskeleton to the hip flexors during walking could provide higher and more consistent metabolic cost reduction than previously achieved. Eight older adults walked on a treadmill at a constant speed of 1.1 m/s with and without the hip assistive device. Metabolic power and spatiotemporal parameters were measured during walking in these two conditions of testing. The hip assistive device was able to apply a low torque which initiates its assistive effect at mid-stance. This reduced the metabolic cost of walking across all the participants with respect to free walking (−4.2 ± 1.9%; p = 0.002). There were no differences in the spatiotemporal parameters reported. This study strengthened the evidence that passive assistive devices can be a valuable tool to reduce metabolic cost of walking in older adults. These findings highlighted the importance of investigating torque profiles to improve the performance provided by a hip assistive device. The simplicity and usability of a system of this kind can make it a suitable candidate for improving older adults’ independence.