bluuebunny/crossref_metadata_2025 huggingface dataset:
Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk
Authors: Rhodri J. King  , Katharina Schuett  , Christian Tiede  , Vera Jankowski  , Vicky John  , Abhi Trehan  , Katie Simmons  , Sreenivasan Ponnambalam  , Robert F. Storey  , Colin W.G. Fishwick  , Michael J. McPherson  , Darren C. Tomlinson  , Ramzi A. Ajjan
Published: May 2020

Complement C3 binds fibrinogen and compromises fibrin clot lysis thereby enhancing thrombosis risk. We investigated the role of fibrinogen-C3 interaction as a novel therapeutic target to reduce thrombosis risk by analysing: i) consistency in the fibrinolytic properties of C3, ii) binding sites between fibrinogen and C3 and iii) modulation of fibrin clot lysis by manipulating fibrinogen-C3 interactions. Purified fibrinogen and C3 from the same individuals (n=24) were used to assess inter-individual variability in the anti-fibrinolytic effects of C3. Microarray screening and molecular modelling evaluated C3 and fibrinogen interaction sites. Novel synthetic conformational proteins, termed Affimers, were used to modulate C3-fibrinogen interaction and fibrinolysis. C3 purified from patients with type 1 diabetes showed enhanced prolongation of fibrinolysis compared with healthy control protein [195±105 and 522±166 seconds, respectively (p=0.04)], with consistent effects but a wider range (5-51% and 5-18% lysis prolongation, respectively). Peptide microarray screening identified 2 potential C3-fibrinogen interactions sites within fibrinogen β chain (residues 424-433, 435-445). One fibrinogen-binding Affimer was isolated that displayed sequence identity with C3 in an exposed area of the protein. This Affimer abolished C3-induced prolongation of fibrinolysis (728±25.1 seconds to 632±23.7 seconds, p=0.005) and showed binding to fibrinogen in the same region that is involved in C3-fibrinogen interactions. Moreover, it shortened plasma clot lysis of patients with diabetes, cardiovascular disease or controls by 7-11%. C3 binds fibrinogen β-chain and disruption of fibrinogen-C3 interaction using Affimer proteins enhances fibrinolysis, which represents a potential novel target tool to reduce thrombosis in high risk individuals.
Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression
Authors: Antonio G. Solimando  , Matteo C. Da Vià  , Patrizia Leone  , Paola Borrelli  , Giorgio A. Croci  , Paula Tabares  , Andreas Brandl  , Giuseppe Di Lernia  , Francesco P. Bianchi  , Silvio Tafuri  , Torsten Steinbrunn  , Alessandra Balduini  , Assunta Melaccio  , Simona De Summa  , Antonella Argentiero  , Hilka Rauert-Wunderlich  , Maria A. Frassanito  , Paolo Ditonno  , Erik Henke  , Wolfram Klapper  , Roberto Ria  , Carolina Terragna  , Leo Rasche  , Andreas Rosenwald  , K. Martin Kortüm  , Michele Cavo  , Domenico Ribatti  , Vito Racanelli  , Hermann Einsele  , Angelo Vacca  , Andreas Beilhack
Published: May 2020

Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated whether BM MM endothelial cells (MMECs) control disease progression via the junctional adhesion molecule A (JAM-A). Membrane and cytoplasmic JAM-A levels were upregulated in MMECs in 111 newly diagnosed (NDMM) and 201 relapsed-refractory (RRMM) patients compared to monoclonal gammopathy of undetermined significance (MGUS) and healthy controls. Elevated membrane expression of JAM-A on MMECs predicted poor clinical outcome. Mechanistically, addition of recombinant JAM-A to MMECs increased angiogenesis whereas its inhibition impaired angiogenesis and MM growth in 2D and 3D in vitro cell culture and chorioallantoic membrane-assays. To corroborate these findings, we treated MM bearing mice with JAM-A blocking mAb and demonstrated impaired MM progression corresponding to decreased MM-related vascularity. These findings support JAM-A as an important mediator of MM progression through facilitating MM-associated angiogenesis. Collectively, elevated JAM-A expression on bone marrow endothelial cells is an independent prognostic factor for patient survival in both NDMM and RRMM. Blocking JAM-A restricts angiogenesis in vitro, in embrio and in vivo and represents a suitable druggable molecule to halt neoangiogenesis and MM progression.
Subcutaneous daratumumab in patients with relapsed or refractory multiple myeloma: Part 2 of the open-label, multicenter, dose-escalation phase 1b study (PAVO)
Authors: Jesus San-Miguel  , Saad Z. Usmani  , Maria-Victoria Mateos  , Niels W.C.J. van de Donk  , Jonathan L. Kaufman  , Philippe Moreau  , Albert Oriol  , Torben Plesner  , Lotfi Benboubker  , Kevin Liu  , Peter Hellemans  , Tara Masterson  , Pamela L. Clemens  , Man Luo  , Andrew Farnsworth  , Hareth Nahi  , Ajai Chari
Published: May 2020

Intravenous daratumumab is approved for the treatment of multiple myeloma. In Part 1 of the PAVO study, a mix-and-deliver subcutaneous formulation of daratumumab with recombinant human hyaluronidase PH20 (rHuPH20) was well tolerated, with low rates of infusion-related reactions and similar efficacy to intravenous daratumumab. Part 2 of PAVO evaluated a concentrated, pre-mixed co-formulation of daratumumab and rHuPH20 (DARA SC). Patients with ≥2 prior lines of therapy, including a proteasome inhibitor and immunomodulatory drug, received daratumumab (1800 mg) and rHuPH20 (30,000 U) in 15 mL subcutaneously over 3-5 minutes per the approved intravenous monotherapy dosing schedule. Primary endpoints were daratumumab trough concentration at the end of weekly dosing (just prior to the Cycle 3 Day 1 dose) and safety. Twenty-five patients were enrolled in PAVO Part 2. DARA SC achieved daratumumab trough concentrations similar to or greater than intravenous daratumumab 16 mg/kg. The adverse event profile of DARA SC was consistent with intravenous daratumumab, with no new safety concerns and a lower infusion-related reaction rate. At a median follow-up of 14.2 months, the overall response rate was 52%, median duration of response was 15.7 months, and median progression-free survival was 12.0 months. DARA SC 1800 mg was well tolerated in relapsed/refractory multiple myeloma, with a low infusion-related reaction rate and reduced administration time. Daratumumab serum concentrations following DARA SC were consistent with intravenous dosing, and deep and durable responses were observed. Based on these results, ongoing studies are investigating DARA SC in multiple myeloma and other conditions. (ClinicalTrials.gov identifier: 02519452).
Challenges of NATO aspıratıon: the dıscrepancy between rhetorıc and realıty
Authors: Iskandarov Khayal , Gawliczek Piotr
Published: May 2020

The Russo-Georgia war in 2008 and the conflict in Ukraine in 2014 galvanized the countries, which are namely squeezed between NATO and Russia into considering their strategies again. The paper examines Russia’s efforts to maintain its influence in its “near abroad” in the face of NATO’s enlargement. It principally focuses on identifying the challenges particular countries face as obstacles to NATO accession. The arguments raised in the paper prove that, the primary reasons of Russia-Georgia War and Ukraine conflict are associated with these countries’ NATO aspiration. An argument regarding the Alliance’s reluctance to actively engage in partner nations is also presented.

The objective of the study is to consider the repercussions of NATO aspiration and introduce the real prospects of cooperation with NATO. The research methods primarily used in the book are comparative analysis and synthesis.
The invisibility of social movements in international press coverage of the Catalan sovereignty process
Authors: Mauri-Ríos Marcel , Pont-Sorribes Carles , Perales-García Cristina
Published: May 2020

We describe partial results from a study on the construction of the international image of the political process in Catalonia in recent years in the main European and the US newspapers. In particular, using several analytical techniques we determine the presence of civil society organisations for and against independence in press articles between July 2010 (the first mass demonstration, in this case against a Spanish Constitutional Court ruling on the Catalan Statute of Autonomy) and October 2017 (the self-determination referendum). To detect the dominant frame, a framing analysis was undertaken from a communicative and deductive perspective, applying the widely tested and used Semetko and Valkenburg (2000) classification.

The international press has generally depicted the Catalan sovereignty process as a conflict involving institutions and politicians, despite the fact that the Catalan process has always been claimed as an initiative with social and cultural roots. The research concludes that, although social movements and civil society played a significant role in the emergence of the sovereignty movement, these have been rendered largely invisible by the international press.
Leadership of Integrated Health and Social Care Services
Authors: Elliott Ian C. , Sinclair Caroline , Hesselgreaves Hannah
Published: May 2020

This research explores the lived experience of those individuals charged with leading the integration of health and social care services in Scotland. The research was primarily qualitative in nature – comprising of a qualitative survey of front-line managers of integrated health and social care services from a single partnership area. The survey explored the management and leadership tasks and activities expected of those leading health and social care teams. The research uncovers a sense that these new leadership positions are both overwhelming in the scope of tasks required and lack clarity in how these tasks should be undertaken. This highlights a need for coordinated support and training for staff who are charged with leading integrated health and social care teams. Three key recommendations have been drawn from the findings of this research: more support should be provided to managers working within these complex integrated systems; a joint training programme should be developed for managers across both partnering organisations and finally relevant policies and procedures should be compiled into one reference resource for managers of integrated services.
The Level of Serum C-Reactive Protein and Neutrophil Lymphocyte Ratio According to Thyroid Function Status
Authors: KAR Fatih , KİRAZ Zeynep Küskü , KOCATÜRK Evin , USLU Sema
Published: May 2020

Objective: We aimed to investigate neutrophil lymphocyte ratio (NLR), leukocyte count (WBC), mean platelet volume (MPV) and C-reactiveprotein levels (CRP) as inflammatory markers according to thyroid function status in hypo-hyperthyroidism patients.Methods: Data of patients (n=454, age>18) who applied to the Eskisehir Osmangazi University Hospital between March 2018 and December2018 were evaluated retrospectively. There were 79 patients in hyperthyroidism group (TSH<0.27 μIU/ml, group I), 297 patients in euthyroidgroup (TSH=0.27-4.2 μIU/ml, group II) and 78 patients in hypothyroidism group (TSH>4.2 μIU/ml, group III).Results: Serum TSH, fT4, fT3, anti-TG and anti-TPO levels were found statistically different between groups (p<0.001) but there were nosignificant difference in WBC, NLR and MPV between groups. There was a positive correlation between the NLR and CRP (r=0,295, p<0.01). Inaddition, NLR was positively correlated with WBC (r=0,412, p<0.001). Serum CRP levels were statistically higher in group I (3.5 mg/L [1.50-11])than group II (2.1 mg/L [0.86-5.42]), (p<0.001). Although CRP levels were higher in group III (2.5 mg/L [1.18-5.73]) than group II, there was nosignificant difference. CRP showed weak positive correlation with fT4 (r=0,118, p<0.05) and negative correlation with TSH (r=-0,108, p<0.05).Conclusion: High CRP levels may play an important role in the evaluation of hyperthyroidism in terms of thyroid dysfunction observed in thepresent study.
Reliability and Validity of Nurses’ Experiences of Infection Prevention and Control Questionnaire
Authors: AKTAŞ Eda , ÇÖVENER ÖZÇELİK Çağrı , OCAKÇI Ayşe Ferda
Published: May 2020

Objective: Nosocomial infections are the primary reason of morbidity and mortality especially at children’s hospitals. Thus, educating pediatric health care providers is rather crucial in order to protect children from exposure to infection. This study was planned to examine reliability and validity of Nurses’ Infection Prevention and Control Observation Questionnaire in Turkish Language. Methods: This methodological study was carried out at a randomly selected Children’s Hospital from each of the 7 regions of Turkey. In total, 443 pediatric nurses from those hospitals participated in the study. Content validity, construct validity, inter-consistency reliability and item total correlation of the questionnaire were analysed in order to adjust reliability and validity. Results: The questionnaire has good content, face and construct validity. The acceptable level for scales’ items was above 0.30 and had one factor according to results of explanatory factor analysis. The questionnaire model fitted the data according to confirmatory factor analysis. A level of Cronbach's alpha at 0.74 was considered to be an acceptable level of reliability and item-total score correlation of the study –except for four items- was identified above 0.30.Conclusion: The questionnaire was determined as a reliable and validate tool in evaluation of observation for nurses’ infection prevention and control.
METODOLOGIAS ÁGEIS PARA O DESENVOLVIMENTO DE SOFTWARES
Authors: Pontes Thiago Bessa , Arthaud Daniel Dias Branco
Published: May 2020

O desenvolvimento de software é uma atividade muito complexa. Devido a essa complexidade a Engenharia de Software foi criada. Ela tem por objetivo aumentar a produtividade no desenvolvimento e melhorar a qualidade do produto gerado. Diversas metodologias e práticas surgiram com a intenção de direcionar o desenvolvimento. Inicialmente vieram as metodologias chamadas tradicionais: cascata, prototipação, incremental. Elas traziam junto consigo muita rigidez e cada passo delas gerava diversos artefatos e documentações, mesmo assim os resultados entregues pelos projetos geravam resultados abaixo do esperado. Com isso, metodologias ágeis surgiram com a proposta de fornecer agilidade de resposta e flexibilidade de adaptação no desenvolvimento trazendo um diferencial competitivo através de velocidade e qualidade dos resultados. Esta revisão técnica tem como objetivo apresentar um mecanismo para desenvolvimento ágil de software de modo a atender com mais rapidez e qualidade, reduzindo dessa forma o consumo desnecessário de recursos, auxiliando na promoção de um sistema sustentável. Compreendeu-se que essas técnicas ágeis trouxeram uma grande evolução na troca de experiência, comunicação, transmissão de conhecimento, confiança das pessoas, confiança do cliente. E isso faz com que a produtividade da equipe cresça e também faz com que a satisfação do cliente seja maior.
UMA SOLUÇÃO CONTRA O DESCARTE DE CANTONEIRAS PLÁSTICAS COM BASE NO DESIGN DE PRODUTOS
Authors: Trindade Ana Paula de Oliveira , Santos Deborah Macêdo
Published: May 2020

Este artigo apresenta uma alternativa, no design de luminárias, ao descarte de materiais (cantoneiras plásticas) oriundos das fábricas de móveis modulados. É feito um estudo de caso em uma loja na cidade de Juazeiro do Norte quanto ao descarte para caracterização e quantificação do mesmo. Seguindo a metodologia de Lobäch, foram feitos estudos de design para a elaboração de projetos de luminárias que reutilizem estes materiais descartados. Esta alternativa proposta interfere diretamente nas dimensões ecológicas, ambientais e econômicas da sustentabilidade. Pode ainda interferir indiretamente na dimensão social e cultural visto que a produção das luminárias pode aumentar a geração de empregos e, da maneira como foi desenvolvida, por pesquisa em design, pode ser incorporada na identidade cultural da região. Esta investigação conseguiu alcançar os objetivos de forma eficaz, propondo uma alternativa viável de reutilização das cantoneiras plásticas em luminárias, que podem, inclusive, ser comercializadas na própria loja de moveis que as descartaria. Como validação dos resultados propostos, foram feitos dois protótipos físicos, uma luminária de mesa e um paflon, que utilizaram 128 e 64 cantoneiras plásticas respectivamente. Assumindo que são descartadas mais de 2000 cantoneiras por loja, todo mês, podem-se executar 18 luminárias de mesa ou aproximadamente 36 paflons, acabando com este descarte.Palavras-chave: Sustentabilidade; Sustentável; Design; descarte de plástico;luminárias.
Automated Image Analyses of Glomerular Hypertrophy in a Mouse Model of Diabetic Nephropathy
Authors: Østergaard Mette V. , Sembach Frederikke E. , Skytte Jacob L. , Roostalu Urmas , Secher Thomas , Overgaard Agnete , Fink Lisbeth N. , Vrang Niels , Jelsing Jacob , Hecksher-Sørensen Jacob
Published: May 2020

Background

Glomerular hypertrophy is a hallmark of kidney injury in metabolically induced renal diseases such as obesity-associated glomerulopathies and diabetic nephropathy (DN).

Methods

Using light sheet fluorescent microscopy (LSFM) and 3D image analysis, we tested algorithms for automated and unbiased quantification of total glomerular numbers and individual glomerular volume in the uninephrectomized (UNx) db/db mouse model of DN.

Results

At 6 weeks after surgery, db/db and UNx db/db mice showed increased urine albumin-to-creatinine ratio (ACR) compared with db/+ control mice. Before euthanasia, glomeruli were labeled in vivo by injecting tomato lectin. Whole-kidney LSFM 3D image analysis revealed that mean glomerular volume was significantly increased in UNx db/db mice compared with db/+ mice. Moreover, analysis of individual glomerular volume showed a shift in volume distribution toward larger glomeruli and thereby demonstrated additive effects of diabetes and UNx on induction of glomerular hypertrophy. The automatized quantification showed no significant differences in glomerular numbers among db/+, db/db, and UNx db/db mice. These data correlated with glomerular numbers as quantified by subsequent stereologic quantification.

Conclusions

Overall, LSFM coupled with automated 3D histomorphometric analysis was demonstrated to be advantageous for unbiased assessment of glomerular volume and numbers in mouse whole-kidney samples. Furthermore, we showed that injection of fluorescently labeled lectin and albumin can be used as markers of nephron segments in the mouse kidneys, thus enabling functional assessment of kidney physiology, pathology, and pharmacology in preclinical rodent models of kidney disease.
Pattern and predictability of potential wind assistance for waders and geese migrating from West Africa and the Wadden Sea to Siberia
Authors: Piersma Theunis , Van de Sant Sjon
Published: May 2020

We have analysed published wind data from the period 1979–1991 to evaluate to what extent migrating waders and geese might benefit from tailwind assistance when flying at altitudes ranging from ground level up to 5.5 km from West Africa (Banc d’Arguin, Mauritania) to the Wadden Sea (Netherlands, Germany and Denmark) in late April and early May, and from the Wadden Sea to Taymyr Peninsula (central Siberia) in late May and early June. Between West Africa and the Wadden Sea it is usually advantageous to fly high, with an average tailwind of 15 km/h (mean of yearly averages) for those birds flying along the optimal height track. There were large differences between years though, with 36 km/h tailwind (1983) and 2 km/h headwind (1991) as extreme values. The best altitudes for migration were higher along the northwest African coast than over Europe. There was no evidence for consistent seasonal changes in wind favourability, but “bad” years were consistently bad over the whole season. Between the Wadden Sea and the Taymyr Peninsula wind conditions were better still than for the Banc d’Arguin-to-Wadden Sea journey (long term average for flights along optimal height track is 21 km/h tailwind), with the favourable winds found at intermediate altitudes (1.5–3 km). The wind conditions were less variable between years along the Wadden Sea–Taymyr route. We discuss both the limitations of the current analyses and the scope for future work.
Quaternary glaciation history and glaciology of Jakobshavn Isbræ and the Disko Bugt region, West Greenland: a review
Authors: Weidick Anker , Bennike Ole
Published: May 2020

The Disko Bugt region in central West Greenland is characterised by permanent ice streams, of which Jakobshavn Isbræ is by far the most important. The first thorough studies on the glaciology of the region were conducted over 150 years ago by H.J. Rink, who introduced the terms 'ice streams' and 'Inland Ice'. Rink's work inspired new field work, which has continued to the present, and the long series of observations are unique for an Arctic region.

Cooling during the Cenozoic led to ice-sheet growth in Greenland. A number of interglacial occurrences have been reported from the Disko Bugt region, and during the penultimate glacial stage, the Greenland ice-sheet margin extended to the shelf break. During the last glacial maximum, the ice margin probably extended only to the inner part of the banks on the continental shelf, and large floating glaciers may have been present at this time. During the Younger Dryas cold period, the ice margin may have been located at a marked basalt escarpment west of Disko Bugt.

Disko Bugt was deglaciated rapidly in the early Holocene, around 10 500–10 000 years before present (10.5–10 ka B.P.), but when the ice margin reached the eastern shore of the bay, recession paused, and major moraine systems were formed. With renewed recession, the present ice-margin position was attained around 8–6 ka B.P., and by c. 5 ka B.P. the ice margin was located east of its present position. The subsequent Neoglacial readvance generally reached a maximum during the Little Ice Age, around AD 1850. This was followed by recession that has continued to the present day.

The relative sea-level history shows a rapid sea-level fall in the early Holocene, and a slow rise in the late Holocene. This development mainly reflects a direct isostatic response to the ice-margin history.

Jakobshavn Isbræ is the main outlet from the Greenland ice sheet. It drains c. 6.5% of the present Inland Ice, and produces c. 35–50 km3 of icebergs per year, corresponding to more than 10% of the total output of icebergs from the Inland Ice. The velocity of the central part of the ice stream at the front has been around 7 km/year since records began, but has nearly doubled in recent years. Other calf-ice producing glacier outlets in Disko Bugt produce c. 18 km3 per year. The large calf-ice production of Jakobshavn Isbræ may have been initiated at about 8 ka B.P. when the glacier front receded from the iceberg bank (Isfjeldsbanken) near Ilulissat. Ice streams in inner and outer Egedesminde Dyb may have been active during the early Holocene and during the last glacial maximum.
Greenland ice sheet monitoring network (GLISN): a seismological approach
Authors: Dahl-Jensen Trine , Larsen Tine B. , Voss Peter H.
Published: May 2020

The dynamics of the large outlet glaciers in Greenland is attracting both scientific and political attention due to the possible implications of a rising global sea level. Extensive glaciological and meteorological monitoring programmes have been implemented to quantify and track changes in the ice sheet and local glaciers (Ahlstrøm et al. 2008). The dynamic processes controlling the flow of the outlet glaciers are complex and poorly understood, involving a wealth of parameters such as bed conditions, hydrology and meteorological conditions. It is desirable to obtain as many fundamentally independent data sets as possible to understand and eventually predict the behaviour of the outlet glaciers.
Zircon record of the igneous and metamorphic history of the Fiskenæsset anorthosite complex in southern West Greenland
Authors: Keulen Nynke , Næraa Tomas , Kokfelt Thomas F. , Schumacher John C. , Scherstén Anders
Published: May 2020

The Fiskenæsset complex in southern West Greenland is part of the North Atlantic craton and is a layered intrusion consisting of gabbro, ultramafic and anorthositic rocks that was deformed during multiple episodes of folding and metamorphism (Myers 1985). We collected late-stage magmatic hornblenditic dykes and adjacent anorthosites and studied these samples integratively with several in situ techniques to determine the igneous and metamorphic history of the Fiskenæsset complex. The work presented here is part of an ongoing joint project between the Greenland Bureau of Minerals and Petroleum and the Geological Survey of Denmark and Greenland (GEUS). Here we report on new radiometric ages and mineral chemistry data from anorthosites from the North Atlantic craton in southern West Greenland (Fig. 1).
An advancing glacier in a recessive ice regime: Berlingske Bræ, North-West Greenland
Authors: Dawes Peter R. , Van As Dirk
Published: May 2020

Greenland is receiving unprecedented international attention, both in scientific and political circles. Characterised by a central ice sheet up to 3.4 km thick (Inland Ice), numerous ice caps and hundreds of outlet glaciers debouching into the surrounding oceans, Greenland supports the second largest ice mass in the world. Analysis of glacier movements, melt rates and ice loss to the sea, provide data with which to assess mass balance changes and thereby predict global sealevel rise. Thus Greenland plays a central role in the current worldwide debate on climate change. Present-day dynamic ice loss is invariably advertised by the fast moving glaciers of western Greenland with their spectacular calf ice production, such as the ice streams around Disko Bugt reviewed by Weidick & Bennike (2007). This tends to overshadow ice stability and expansion seen in the form of stationary and advancing glaciers elsewhere in Greenland (MODIS 2009). While the seawards acceleration of glacier flow and retreat in frontal positions can be readily attributed to a shift in atmospheric and oceanic conditions (global warming), the same explanation can hardly be used for glaciers with contrasting movement histories.
Factors of Performance for Application of AI Models in GPU Cloud
Authors: Tulchinsky Vadim , Lavreniuk Serhii , Roganov Viacheslav , Tulchinsky Petro , Khalimendik Valerii
Published: May 2020

Introduction. In machine learning (ML) and artificial intelligence (AI) works, the emphasis is usually on the quality of classification or the accuracy of parameter estimation. If the focus is on performance, then it is also mainly about the performance of the model's training phase. However, with the proliferation of AI applications in real-world problems, the problem of ensuring high data processing performance with ready models becomes more important. By its nature, this problem is fundamentally different from the one of model training: the latter deals with intensive calculations and the former with simple calculations, but large flows of data (files) coming from the network or file system for processing. That is, the typical task of parallel processing with intensive input-output.

Besides, in terms of application, the AI module that performs classification, evaluation, or other data processing is a "black box": the cost of developing and training the model, as well as the risks of failure, are too high to handle such tasks in a non-professional manner. Therefore, performance optimization primarily involves the selection and balancing of system parameters. Cloud systems with their flexibility, manageability and easy scaling are the ideal platforms for such tasks.

Consider in more detail the task of investigating the factors which affect performance on a single, but notable, pattern recognition sample of a subset of ImageNet image collection [1] classified by the 50-layer deep learning neural network ResNet-50 [2].

The purpose of the paper is to experimentally investigate the factors that influence the performance of a ready-to-use neural network model application in GPU cloud systems of various architectures.

Results. Overheads related to microservices and distributed architectures, memory, network, batch size, synchronous and asynchronous interactions are estimated. The complex nonlinear nature of the influence of the system parameters in various combinations is demonstrated.
PENGARUH PEMBERIAN OKSIGEN DAN ELEVASI KEPALA 30º TERHADAP TINGKAT KESADARAN PADA PASIEN CEDERA KEPALA SEDANG
Authors: Ginting Luci Riani , Sitepu Kuat , Ginting Renni Ariana
Published: May 2020

Head injury is directly or indirectly mechanical injuries that resulted wound in the scalp, skull fracture, tear the lining of the brain, and brain damage, and neurological disorders. The basic method for brain protection of head injury patients are freeing the airway and giving adequate oxygenation. Giving oxygen and headv elevation 30° of head are the appropriate action for the moderate head injury classification to launch the cerebral oxygen perfusion and to increase consciousness level. The purpose of this research were to determine the GCS before and after giving oxygenation with and position 30 ° of head and to analyze the effect of giving oxygen and headv elevation30 °of head to change the levels of consciousness of moderate head injury patients. This research was an Quasi-Experimental study with 10 respondents. The test were used Paired Sample T-test Test. The results showed that there was an effect of giving oxygen and headv elevation 30 °of head toward to change the level of consciousness of moderate head injury patients. GCS average value before was 10.10 and GCS average after 12.90 value was with p value was 0.000.

Keywords : Levels of Consciousness GCS, Moderate Head Injury, Position 30° of the Head
PENGARUH PEMBERIAN D-GALAKTOSA TERHADAP PERUBAHAN BERAT BADAN MENCIT JANTAN
Authors: Sari Indah Permata , Ichwan Muhammad , Siregar Yahwardiah
Published: May 2020

D-galactose is aldohexose which occurs naturally in the body, including in the brain which is found in lactose disaccharides in honey, beets and milk products. Needed in the body for lactose formation during the process of lactogenesis. Provision of large amounts of D-galactose can cause oxidative damage to various tissues and organs. The purpose was to see changes in body weight in male rats after being given a D-galactose injection. Samples using male mice aged 8 weeks with a weight of ± 30 grams, the number of samples was 6 mice swiss webster strain. intra-peritoneal injection of D-galactose is given for 6 weeks every day (150 mg / kg / bb). The results of this study indicate that the statistical analysis is significant p <0.05 (p = 0.016). The conclusion after being given injection of D-galactose for 6 weeks every day intra peritoneally was found D-galactose had an effect on the weight gain of male mice.
HUBUNGAN LAMA MENGIKUTI BABY SPA DENGAN KENAIKAN BERAT BADAN BAYI USIA 0-6 BULAN DI YAYASAN IBU SEJATI MANDIRI KECAMATAN TUNTUNGAN KOMPLEKS MEDAN PERMAI KOTA MEDAN TAHUN 2018
Authors: Wahyuni Faradita , Purwana Rudi , Matondang Desyi Gusharni
Published: May 2020

Abstract

Background;Babies who attend baby spas on a regular basis will produce weight gain of up to 47% -80% for a month, while babies who do not regularly attend baby spas only 2 times a week experience a weight gain of 15-30%. Objectives;The purpose of this study is to find out the Relationship of the Length in Attending Baby Spa with 0-6 Months Old Baby’s Weight Gain at Ibu Sejati Mandiri Foundation Tuntungan Sub District, Komplek Medan Permai Kota in 2018. Method; This type of research is an analytical survey with a cross sectional approach. The population of this study were all infants aged 0-6 months totaling 32. The sample in this study was a 0-6-month-oldin July to September with a total of 32 babies at Ibu Sejati Mandiri Foundation.Results; There is a long relationship following the baby spa with weight gain infants aged 0-6 months with the results of the calculation p value = 0,000 <α = 0.05. Conclusion;There is Relationship of the length in attending Baby Spa with Weight gain for 0-6-month-olds at Ibu Sejati Mandiri Foundation Medan in 2018. It is suggested for future researchers to be able to make this research as an experience and knowledge, especially about Baby Spa.
PENGARUH PEMBERIAN KOMPRES KOL TERHADAP PENURUNAN PEMBENGKAKAN PAYUDARA PADA IBU POST PARTUM DI KLINIK BERSALIN KASIH IBU DELI TUA KABUPATEN DELI SERDANG TAHUN 2019
Authors: Ariescha Putri Ayu Yessy , Manalu Andayani Boang , Siagian Nurul Aini , Yanti Mutiara Dwi , Tarigan Rehulina
Published: May 2020

One of common problems associated with breastfeeding is breast engorgement. This breast swelling can cause the mother to stop breastfeeding. This study aims to determine the effect of cabbage compresses on reducing breast engorgement in postpartum mothers at Kasih Ibu Primary Clinic in Deli Tua in 2019. The research used quasi-experimental, one-group pretest-posttest method design. The sampling technique used convenience sampling to recruit 30 postpartum mothers who had breast engorgement. The instrument used to measure breast swelling was the breast engorgement assessment scale of Hill and Hummenick which consisting of a scale of 1 to 6. Application of cabbage compresses was done by attaching cabbage to the breast until the cabbage withers. This procedure was repeated four times every 6 hours per day, for 2 days. The results of the study showed that at the time before being compressed all the research subjects had a score of 4. On the 1st day of compressing with cabbage leaves, there were 7 people (23.3%) who had decreased breast swelling and on the 2nd day of compressing, the total postpartum mothers experienced a decreased in breast engorgement was 9 people (30%). Statistical analysis by paired t-test obtained the value of p = 0.001 (p <0.05). Thus, the results of this study concluded that there was a significant influence of cabbage compresses to decrease breast engorgement of the postpartum mothers at Kasih Ibu Primary Clinic in Deli Tua in 2019.
PENGARUH SENAM NIFAS TERHADAP PROSES INVOLUSI UTERI PADA IBU POSTPARTUM
Authors: Saputri Ika Nur , Gurusinga Rahmad , Friska Nurmailaini
Published: May 2020

Postpartum hemoragic is caused by unfavorable uterine involution, therefore early ambulation with puerperal gymnastics is necessary. Puerperal gymnastics is one way for early mobilization that is highly recomended for post partum mothers so that the process of involution is smooth. The purpose of the study was to determine the effect of puerperal gymnastics by uterine involution in post partum in midwife clinick Nining Pelawati in lubuk pakam sub-district with terrain city in 2019. The research medhod is a pre-experiment with respondent totaling 30 normal post partum mothers at the seka sriwahyuni midwife clinic consisting of 15 morhers who performed puerperal gymnastics (eksperimental respondent group). And 15 mothers who did not do purperal gymnastics (group of control respondents). Data collection uses observation while the formula uses the dependent t-test, the results of the study of the speed of uterine involution in mothers who do puerperal gymnastics are mostly in the fast category as much as 8 people (53,3%), the rest are in the normal categori as many as 5 people (33,3%), while those in the slow category do not exit (0,00%). The rate of uterine involution in pospartum women who do not do partuirition gymnastics in the majority in the slow category in 9 people (60,6%), the rest are in the normal category as 4 people (26,6%), while in the fast category as many as 2 people (13,3%). It can be concluded differences in changen in uterine involution between intervention groups ang control groups.
PENGARUH PENERAPAN PIJAT DAN RENDAM KAKI DENGAN AIR HANGAT CAMPURAN KENCUR TERHADAP EDEMA KAKI PADA IBU HAMIL
Authors: Yanti Mutiara Dwi , Purba Tetty Junita , Ariescha Putri Ayu Yessy , Manalu Andayani Boang , Siagian Nurul Aini , . Mardiah
Published: May 2020

Physiological foot edema was found in about 80% of pregnant women. This occurs due to suppression of the uterus which inhibits venous return. Physiological foot edema if not treated can cause discomfort, feeling heavy, and cramps at night. This study aim to analize the effect of applying foot massage and soaking feet with warm water mixed with kaempfaria galanga L against foot edema in pregnant women in the village of Tulaan Kec. Gunung Meriah district. Aceh Aingkil. This type of research is Quasy Experiment with one group pre-test and post-test design. The population was all The population in this study were all pregnant women who experienced physiological edema of the feet to pregnancy in Tulaan Village, Kec. Gunung Meriah Regency. Aceh Singkil in 2019. The sampling technique was done by total sampling which received 10 respondents and analyzed by Dependent T-Test significance level p = 0.05. The results showed that there was a significant effect on the application of foot massage and foot soaking with warm water mixed with kaempfaria galanga L against foot edema in pregnant women. Significant results indicate that p = 0,00 <0,05. the conclusion in this study is foot massage and soaking the feet with warm water mixed with Kaempfaria Galanga L proven effective in reducing physiological edema in pregnant women. Therefore Kaempfaria Galanga L can be made as a complementary alternative therapy in pregnant women with physiological edema.
PENGARUH INISIASI MENYUSU DINI TERHADAP INVOLUSI UTERUS PADA IBU POSTPARTUM
Authors: Ginting Desideria Yosepha , Nirwana Syafria , Sara Arfah May , Tarigan Layari
Published: May 2020

Early Breastfeeding Initiation is the process of breastfeeding babies as soon as they are born and can not be postponed by weighing or measuring the baby. The purpose of this study was to determine the effect of Early Breastfeeding Initiation on uterine involution in postpartum mothers. This type of research is Quarsi Experimental Design with observation research. the population in this study were all postpartum mothers at Tutun Sehati Tanjung Morawa’s Clinic Deli Serdang Regency. Samples taken amounted to 10 people, used with observation techniques, which were divided into two groups, namely control (which was not given Early Breastfeeding Initiation) and intervention (given IMD).The result that the average Uterine Revolution in postpartum mothers who were controlled was 11.40 with a standard deviation of 0.54.while the intervention group performed by Early Breastfeeding Initiation was 9.20 with a standard deviation of 0.47. so there is an effect of Early Breastfeeding Initiation on uterine involution in postpartum mothers with a p-value = 0.003 (P <0.05), It is recommended that health workers do Early Breastfeeding Initiation to postpartum mothers to accelerate the decrease in uterine involution.
STEM Leadership and Training for Trailblazing Students in an Immersive Research Environment
Authors: Villafañe-Delgado Marisel , Johnson Erik C. , Hughes Marisa , Cervantes Martha , Gray-Roncal William
Published: May 2020

Educating the workforce of tomorrow is an increasingly critical challenge for areas such as data science, machine learning, and artificial intelligence. These core skills may revolutionize progress in areas such as health care and precision medicine, autonomous systems and robotics, and neuroscience. Skills in data science and artificial intelligence are in high demand in industrial research and development, but we do not believe that traditional recruiting and training models in industry (e.g., internships, continuing education) are serving the needs of the diverse populations of students who will be required to revolutionize these fields. Our program, the Cohort-based Integrated Research Community for Undergraduate Innovation and Trailblazing (CIRCUIT), targets trailblazing, high-achieving students who face barriers in achieving their goals and becoming leaders in data science, machine learning, and artificial intelligence research. Traditional recruitment practices often miss these ambitious and talented students from nontraditional backgrounds, and these students are at a higher risk of not persisting in research careers. In the CIRCUIT program we recruit holistically, selecting students on the basis of their commitment, potential, and need. We designed a training and support model for our internship. This model consists of a compressed data science and machine learning curriculum, a series of professional development training workshops, and a team-based robotics challenge. These activities develop the skills these trailblazing students will need to contribute to the dynamic, team-based engineering teams of the future.
Some FDA Approved drugs exhibit binding affinity as high as -16.0 kcal/mol against COVID-19 Main Protease (Mpro): A Molecular Docking Study
Authors: Subramanian Shanmuga
Published: May 2020

Currently the new Coronavirus "COVID-19", also known as SARS-CoV-2, has infected nearly 3 million patients and nearly 200,000+ people have lost their lives due to this pandemic. There is an urgent need to find an antiviral agent that may slow down the spread of the virus. The aim of this study is to assess and evaluate some FDA Approved drugs as potential inhibitors for COVID-19 Main Protease (Mpro) (PDB code: 6LU7). This will be done by blind molecular docking using PyRx and Auto Vina software. The compounds Hydroxychloroquine and Remdesivir were used for comparative study. The binding energies obtained from the docking of 6LU7 with Midostaurin, Zafirlukast, Eluxadoline, Naldemedine, Netupitant, Pancuronium, Letermovir, Baloxavir marboxil, Tazemetostat, Telotristat ethyl, Zeaxanthin, Lutein, Deserpidine, Cefotetan, Procaine benzylpenicillin were -16, 15.6, -15.3, -15.2, -15.1, -14.8, -14.6, -14.5, -13.8, -13.2, -13.2, -12.4, -12.4 and -11.2 kcal/mol respectively . Therefore some of the drugs can be used in Clinical trials as they are purified compounds of known composition and among all of them are approved drugs,some of them are investigative drugs except Pancuronium. All these drugs should be evaluated for further use by conducting in vitro tests and if they are successful they should evaluated for further use in clinical trials against COVID-19 as they are readily available in the market.
OPTIMIZATION OF THE DECORTICATION PROCESS OF INDUSTRIAL HEMP STEMS BY MATHEMATICAL PLANNING METHOD
Authors: Boyko Galina , Tikhosova Hanna , Ternova Tatiana
Published: May 2020

The paper presents the results of theoretical and experimental studies aimed at optimizing the decortication process of industrial hemp stems. In order to achieve this goal, physical and mechanical properties of industrial hemp straw stems were investigated, with the choice of the main quality indicator - diameter, which directly influences the bast output. Also, with the help of mathematical planning of the experiment, the optimal treatment mode for the stems of industrial hemp with clearing of wood of 5-6% was calculated.
TECHNICAL AND TECHNOLOGICAL SOLUTIONS FOR PRODUCING FIBRE
FROM BAST CROPS
Authors: Вerezovsky Yu. , Kuzmina T. , Lialina N. , Yedynovych M. , Lobov O.
Published: May 2020

The paper is devoted to solving problems related to developing scientific bases for resource-saving technologies in bast crops complex processing. The work contains theoretical and experimental research in processing flax and hemp raw materials.
The work objective is to find ways to improve the production conditions for processing bast fibre plants and to solve the problems of ameliorating the qualitative and quantitative bast fibre characteristics by improving the technological features of stem material processing and structural design application to the joint connections of the devices for processing bast-fibre raw materials. The paper also analyses current trends in the flax and hemp processing industry development, investigates the technical and technological features of processing bast-fibre crop stems and assesses the directions for increasing their processing efficiency.
DESIGN AND THRESHING OUTPUTS STUDY OF INTERNAL AND EXTERNAL ROTARY ROLLER BUCKWHEAT THRESHER
Authors: Wang Jiawei , Li Zhiwei , Hussain Saddam , Lu Qi , Song Haiyan , Zheng Decong
Published: May 2020

In order to study the distribution of buckwheat threshing outputs, on the self-designed internal and external rotary roller buckwheat threshing device test bench, the feeding amount was 0.5 kg/s, the internal roller speed was 380 r/min, and the external roller speed was +50 r/min (same direction as the internal roller), 0 r/min and -50 r/min (reverse direction compared to the internal roller) for threshing test. By analysing the overall condition of the threshing outputs, the content of each component in the threshing outputs, and the axial distribution of the threshing roller, it was found that the receiving box below the rasp bar roller mainly contained grains and chaff, leaves and petals, and the receiving box below the spike tooth roller mainly contained short stalks. Under the three conditions, the proportion of chaff in the threshing outputs was 40-45%, the proportion of leaves and petals was 23-29%, the proportion of grains was 13-19%, the proportion of short stalks was 14-16%. Grains, chaff, leaves and petals were mainly concentrated at the front, and short stalks were mainly distributed at the rear of the threshing roller, providing a theoretical basis for the design of the cleaning system.
VIBRATION AND IMPACT DETECTION OF AXIAL- FLOW THRESHING UNIT UNDER DYNAMIC THRESHING CONDITIONS
Authors: Jiangtao Ji , Jingpeng Hu , Shengsheng Wang , Ruihong Zhang , Jing Pang
Published: May 2020

In order to explore the interaction between the axial-flow threshing unit and the agricultural materials, the vibration signal of the axial-flow threshing unit and the stress signal of the internal threshing tooth under the dynamic threshing condition were detected by using the three-way acceleration sensors and the resistance strain gauges. The results show that under the dynamic threshing condition, the amplitude of the vibration signal along the axial direction of the threshing unit experienced a small change, but changed greatly at the feeding direction of materials and vertical direction of fixed bearings, which was mainly caused by the internal impact between the threshing unit and the materials; Under the impact of materials, the threshing element of each measuring point has a continuous peak value of stress signal, and the stress signals gradually decreased along the axial direction. This study further reveals the interaction mechanism between axial-flow threshing unit and materials from the perspective of vibration and impact, and provides new methods for the development of condition detection technology of grain harvesting equipment.
CONTROL METHOD FOR PARAMETERS COORDINATE MATCH
OF FLUTED ROLLER FERTILIZER APPARATUS
Authors: Feng Huimin , Gao Nana , Li You , Fu Weiqiang , Guo Yuming
Published: May 2020

To improve the fertilization accuracy and distribution uniformity of nitrogen fertilizer, control method of working parameters coordinate match was proposed in this paper. Take minimum coefficient of variation as criterion, the nearly-optimal set of exposure length and rotational speed was solved based on regression models with known values of target fertilizer amount and operating speed, the interfaces were built to rapidly calculate related parameters. The static and dynamic experiments were conducted to verify the reliability and accuracy of regression models and control method; the results showed that under static conditions, the biggest difference value of fertilizer amount is 0.22g per revolution; under dynamic conditions, the deviation of fertilizer amount is less than 4.01%, the maximum deviation of rotational speed is 2.74%. Those results indicate that the control method is practical and feasible for fertilization operation.