bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposed Changes to Asphalt Binder Specifications to Address Binder Quality-Related Thermally Induced Surface Damage
Authors: Elwardany Michael D. , Planche Jean-Pascal , King Gayle
Published: January 2022

Superpave specifications address binder properties that may lead to rutting, transverse cracking, and fatigue damage with varying degrees of success. However, asphalt binder production and formulation has significantly changed and introduced much more variability in relation to quality since the development of the Superpave Performance-Grade system because of economic, technical, and environmental reasons. Consequently, aged-induced surface distresses under combined thermal and traffic loading have become the main challenge for highway agencies. Thermally induced surface deterioration appears in the form of traditional transverse cracking, block cracking, and raveling, or accelerating damage at construction joints. This study evaluated the limitations of the proposed linear viscoelastic (LVE) rheological cracking surrogates, such as ΔTc, R-value, and G-R parameters, and the ability of the Asphalt Binder Cracking Device (ABCD) failure test to overcome these limitations. ABCD is particularly appropriate to rank binder performance because the measured cracking temperature (Tcr) encompasses binder LVE properties, failure strength, coefficient of thermal contraction, and cooling rate. The proposed parameter (ΔTf = Tc(S = 300 MPa) from BBR—Tcr from ABCD) relates the failure temperature to the equi-stiffness temperature and gives credit to well-formulated and compatible polymer-modified binders expected to increase binder strength and strain tolerance. This paper proposes a specification framework based on both ΔTc and ΔTf, universally applicable, regardless of binder composition. Additionally, preliminary purchase specification limits for binders used in surface layers are proposed based on the analysis of 44 binders, 15 with corresponding field performance data. Obviously, as confirmed by a recent stakeholder workshop and industry feedback, these preliminary specification limits need further validation and possible adjustments to account for regional experience and local challenges.
Is Oral Contrast Beneficial for Visualization of the Appendix in Low-Weight Children?
Authors: Shapira-Zaltsberg Gali , Dien Esquivel Maria , Mitsakakis Nicholas , Hayawi Lamia , Miller Elka
Published: January 2022

Purpose: It has been shown that oral contrast does not improve the diagnostic accuracy of Computed Tomography (CT) for appendicitis in pediatric patients; however, the cohorts in these studies were not stratified by weight or body mass index. The purpose of this study is to assess the benefit of oral contrast administration for identifying the appendix in younger children in the lower weight quartile. Materials and Methods: This retrospective study comprised 100 patients (2–10 years) in lower weight quartile who had intravenous contrast-enhanced CT of the abdomen and pelvis, 37 of which with oral contrast, and 63 without. A pediatric radiologist and a pediatric radiology fellow independently assessed whether the appendix was visualized or not. In case of discrepancy, an additional pediatric radiologist was the “tie-breaker.” Chi-squared test was used to compare the proportion of visualized appendix between the groups (with and without oral contrast). Inter-rater reliability was determined using Cohen’s Kappa coefficient. Results: There was no significant difference in the visualization of the appendix between the group with oral contrast and without ( P = 1). The Cohen Kappa coefficients were .33 (.05, .62) and .91 (.73, 1.00) for the “no oral” and “oral” groups, respectively, yielding evidence of a difference ( P = .007). Conclusions: There was no significant difference in the visualization of the appendix using CT with or without oral contrast in low-weight pediatric patients. The inter-rater reliability, however, was significantly higher in the group given oral contrast. Additional studies assessing the value of oral contrast for the sole indication of appendicitis may provide clearer results.
Masking for School-Age Children With Epilepsy: We Do Have Consensus!
Authors: Fine Anthony L. , Wong-Kisiel Lily C. , Nickels Katherine C. , Wirrell Elaine C.
Published: January 2022

Introduction

This study was designed to assess current recommendations from child neurologists and epileptologists on masking for school-age children with epilepsy.

Methods

A 7-item survey was created and sent out to members of the Child Neurology Society and Pediatric Epilepsy Research Consortium in August of 2021 to assess current practice and provider recommendations on masking.

Results

One hundred four individuals participated with representation from all regions of the United States. Masking was recommended by 95.1%, with 63.4% (n = 66) noting exception of those with severe intellectual disability, autism, and behavioral problems. Of those who write exemption letters, 54% write these <5% of the time. Only 3% reported potential adverse events associated with masking.

Conclusion

Nearly all respondents recommended masking for school-age children with epilepsy. Potential risks of masking and adverse events were low. Improved guidance on masking is needed to ensure academic success of our patients with epilepsy.
Can Women Shelters Help Reduce Symptoms of PTSD and C-PTSD? Trajectories of PTSD Symptom Development Following Partner- and Family-Related Violence
Authors: Dokkedahl Sarah , Kristensen Trine Rønde , Elklit Ask
Published: January 2022

Background: To protect women from Intimate partner violence (IPV), women’s shelters should not only provide emergency safety from IPV exposure, but also prolonged support that empowers women to build a life free from violence. The present study aims to investigate individual symptom development in association with residency at a women’s shelter. Method: Data were collected at four different timepoints, that is, enrolment (T1, N = 150), 3-months residency (T2, = 110), 6-months residency (T3, N = 68) and after relocation (T4, N = 63). Women were included from four Danish women’s shelters. The International Trauma Questionnaire (ITQ) was applied to test for post-traumatic stress disorder (PTSD) and Complex-PTSD (C-PTSD) at all timepoints. A paired sample t-test was used to test the mean symptom development, and a Latent Class Growth Analysis (LCGA) was applied to test for different classes of PTSD-trajectories. Logistic regression was applied to predict class membership from shelter-related variables and symptom severity, that is, length of residency, psychological counselling, revictimization and key symptoms of C-PTSD. Results: The prevalence of PTSD (31%) and C-PTSD (37.9%) was high at enrolment. Although t-tests suggested a significant decline in symptoms at follow-up, the LCGA revealed different classes of symptom development. The two-class model was found to be the best representation of data with low-symptom- and high-symptom profiles, respectively. Overall, the largest decline in symptoms occurred within the first 3 months of residency. Revictimization was high and was further found to predict class membership. However, when included in a multiple regression only symptom severity predicted the high-symptoms profile class. Discussion: Psychological treatment focussing on PTSD and C-PTSD is important for the women’s future well-being and safety. Reports on revictimization was alarmingly high, which emphasises a continuing need to protect women from psychological violence within the shelters. These findings should be replicated in larger samples before we can draw any conclusion.
Metabolic syndrome predicts new damage in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort
Authors: Elera-Fitzcarrald Claudia , Reatégui-Sokolova Cristina , Gamboa-Cárdenas Rocío V , Medina Mariela , Zevallos Francisco , Pimentel-Quiroz Victor R , Cucho-Venegas Jorge M , Alfaro-Lozano José L , Rodriguez-Bellido Zoila , Pastor-Asurza Cesar A , Perich-Campos Risto , Alarcón Graciela S , Ugarte-Gil Manuel F
Published: January 2022

Objectives

This study aims to determine whether the MetS predicts damage accrual in SLE patients.

Methods

This longitudinal study was conducted in a cohort of consecutive SLE patients seen since 2012 at one single Peruvian institution. Patients had a baseline visit and then follow-up visits every 6 months. Patients with ≥ 2 visits were included. Evaluations included interview, medical records review, physical examination, and laboratory tests. Damage accrual was ascertained with the SLICC/ACR damage index (SDI) and disease activity with the SLEDAI-2K. Univariable and multivariable Cox-regression survival models were carried out to determine the risk of developing new damage. The multivariable model was adjusted for age at diagnosis; disease duration; socioeconomic status; SLEDAI; baseline SDI; the Charlson Comorbidity Index; daily dose; and time of exposure of prednisone (PDN), antimalarials, and immunosuppressive drugs.

Results

Two hundred and forty-nine patients were evaluated; 232 of them were women (93.2%). Their mean (SD) age at diagnosis was 35.8 (13.1) years; nearly all patients were Mestizo. Disease duration was 7.4 (6.6) years. The SLEDAI-2K was 5.2 (4.3) and the SDI, 0.9 (1.3). One hundred and eight patients (43.4%) had MetS at baseline. During follow-up, 116 (46.6%) patients accrued at least one new point in the SDI damage index. In multivariable analyses, the presence of MetS was a predictor of the development of new damage (HR: 1.54 (1.05–2.26); p < 0.029).

Conclusions

The presence of MetS predicts the development of new damage in SLE patients, despite other well-known risk factors for such occurrence.
The Identification of Prognostic and Metastatic Alternative Splicing in Skin Cutaneous Melanoma
Authors: Huang Runzhi , Li Mingxiao , Zeng Zhiwei , Zhang Jie , Song Dianwen , Hu Peng , Yan Penghui , Xian Shuyuan , Zhu Xiaolong , Chang Zhengyan , Zhang Jiayao , Guo Juanru , Yin Huabin , Meng Tong , Huang Zongqiang
Published: January 2022

Skin cutaneous melanoma (SKCM) is a type of highly invasive cancer originated from melanocytes. It is reported that aberrant alternative splicing (AS) plays an important role in the neoplasia and metastasis of many types of cancer. Therefore, we investigated whether ASEs of pre-RNA have such an influence on the prognosis of SKCM and the related mechanism of ASEs in SKCM. The RNA-seq data and ASEs data for SKCM patients were obtained from the TCGA and TCGASpliceSeq database. The univariate Cox regression revealed 1265 overall survival-related splicing events (OS-SEs). Screened by Lasso regression, 4 OS-SEs were identified and used to construct an effective prediction model (AUC: .904), whose risk score was proved to be an independent prognostic factor. Furthermore, Kruskal–Wallis test and Mann–Whitney–Wilcoxon test showed that an aberrant splicing type of aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) regulated by CDC-like kinase 1 (CLK1) was associated with the metastasis and stage of SKCM. Besides, the overlapped signal pathway for AIMP2 was galactose metabolism identified by the co-expression analysis. External database validation also confirmed that AIMP2, CLK1, and the galactose metabolism were associated with the metastasis and stage of SKCM patients. ChIP-seq and ATAC-seq methods further confirmed the transcription regulation of CLK1, AIMP2, and other key genes, whose cellular expression was detected by Single Cell Sequencing. In conclusion, we proposed that CLK1-regulated AIMP2-78704-ES might play a critical role in the tumorigenesis and metastasis of SKCM via galactose metabolism. Besides, we established an effective model with MTMR14-63114-ES, URI1-48867-ES, BATF2-16724-AP, and MED22-88025-AP to predict the metastasis and prognosis of SKCM patients.
Behavioural Challenges Associated With Risk-Adapted Cancer Screening
Authors: Usher-Smith Juliet , von Wagner Christian , Ghanouni Alex
Published: January 2022

Cancer screening programmes have a major role in reducing cancer incidence and mortality. Traditional internationally-adopted protocols have been to invite all ‘eligible individuals’ for the same test at the same frequency. However, as highlighted in Cancer Research UK’s 2020 strategic vision, there are opportunities to increase effectiveness and cost-effectiveness, and reduce harms of screening programmes, by making recommendations on the basis of personalised estimates of risk. In some respects, this extends current approaches of providing more intensive levels of care outside screening programmes to individuals at very high risk due to their family history or underlying conditions. However, risk-adapted colorectal cancer screening raises a wide range of questions, not only about how best to change existing programmes but also about the psychological and behavioural effects that these changes might have. Previous studies in other settings provide some important information but remain to be tested and explored further in the context of colorectal screening. Conducting behavioural science research in parallel to clinical research will ensure that risk-adapted screening is understood and accepted by the population that it aims to serve.
Validation of the Digital Eye Strain Questionnaire and pilot application to online gaming addicts
Authors: Mylona Ioanna , Glynatsis Mikes N. , Dermenoudi Maria , Glynatsis Nikolaos M. , Floros Georgios D
Published: January 2022

Introduction

‘Digital eye strain’ (DES) is a clinical syndrome with eyesight symptoms related to continuous engagement in front of a screen-enabled digital device. With use of these devices constantly on the rise, the related symptoms have become prominent, even in younger ages. This study describes the process of validating the Digital Eye Strain Questionnaire (DESQ), a thirteen-item self-report scale in a yes-no format designed to offer a measure of complaints related to digital eye strain syndrome (DES).

Methods

The validation process included 150 outpatients with no long-standing eye disease who were examined for various eye complaints and 50 outpatients who were diagnosed with gaming addiction according to WHO ICD-11 clinical criteria. All participants filled in a demographics questionnaire, the DESQ, the Computer Vision Syndrome Questionnaire (CVS-Q) and the Problematic Internet Use Questionnaire-9 (PIUQ-9).

Results

Principal component analysis of categorical variables confirmed the proposed three-factor DES structure with a total of 61.02% of explained variance and Cronbach's alpha equal to.94. Concurrent validity was assessed by comparing the results of the DESQ to the CVS-Q while convergent validity was assessed by examining correlations of the DESQ with results from the PIUQ-9 questionnaire. In all cases the DESQ demonstrated excellent reliability and validity.

Conclusions

Results indicate that the DESQ questionnaire can be employed to reliably measure the symptomatology of digital eye strain in clinical populations who present either with eye issues or with excessive use of the gaming and screen-enabled devices in general.
Teachers of TikTok: Glimpses and gestures in the performance of professional identity
Authors: Hartung Catherine , Ann Hendry Natalie , Albury Kath , Johnston Sasha , Welch Rosie
Published: January 2022

During a tumultuous period marked by a global pandemic, forced lockdowns, and educational institutions going ‘digital by default’, TikTok has emerged as a key platform for teachers to connect and share their experiences. These digital practices have been widely celebrated for providing teachers with an outlet during a challenging time, though little is known about the particulars of TikTok's appeal among teachers and their followers. This article focuses on a teacher from South Australia, ‘Mr Luke’, whose upbeat TikTok videos capturing ‘#teacherlife’ have seen him grow a significant following. Drawing on interviews with Mr Luke and an Australian pre-service teacher who follows him, we consider their thoughts on TikTok and its relationship to professional practice. We identify key factors that have enabled TikTok's popularity among educators, with implications for both teacher education and social media scholarship.
A Case of Successful Endovascular Aortic Repair of Primary Aortoenteric Fistula Without Aortic Explantation
Authors: Winston Joshua , Lovelock Thomas , Kelly Thomas , Vasudevan Thodur
Published: January 2022

Purpose:

The objective of this study is to report a case of a primary aortoenteric fistula successfully treated with endovascular repair without aortic explant.

Case Report:

A 48-year-old man presented with a 24-hour history of hematemesis and malena. A computed tomography (CT) abdomen and pelvis demonstrated a 6 cm infrarenal aortic aneurysm with periaortic stranding and contrast enhancement within the lumen of the third part of the duodenum. The patient underwent emergency Endovascular Aortic Repair (EVAR). The patient was discharged on day 8 of his admission on oral antibiotics. He returned 7 weeks postindex procedure and underwent a laparotomy with omental patch repair of the aortic defect. Intraoperative cultures grew candida albicans, and the patient was discharged on lifelong oral Fluconazole and Amoxycillin-Clavulanic Acid. At 18 months postoperatively, the patient was clinically stable with improved appearances on CT aortogram.

Conclusion:

We discuss the use of EVAR without aortic explant as a possible treatment option in the management of patient with primary aortoenteric fistulae. This may potentially avoid the significant morbidity and mortality associated with aortic explant in suitable candidates without perioperative signs of sepsis.
Balloon-Assisted Retrograde Puncture of Distal Vessels in Patients Unsuitable for a Conventional Transpedal Approach
Authors: Ysa August , Lobato Marta , Quintana Ana M. , Ortiz de Salazar Leire , Gómez Roberto , Arruabarrena Amaia , Metcalfe Matthew , Fonseca Juan L.
Published: January 2022

Purpose:

To describe a novel bailout technique to approach below-the-knee chronic total occlusions after a failed bidirectional recanalization attempt using the plantar loop maneuver in patients who are poor candidates for a retrograde puncture.

Technique:

After a failure of recanalization of the opposite tibial artery using the plantar loop maneuver, an assisted direct retrograde transpedal approach can be performed regardless of poor vessel caliber or even arterial occlusion. After crossing the plantar arch, a low profile angioplasty balloon is used as a landmark for the pedal puncture and to give guidance for the wire advancement from the new access.

Conclusion:

A balloon-assisted retrograde transpedal approach may be considered for below-the-knee recanalization after standard plantar loop technique failure in patients who are not candidates for conventional retrograde puncture.
Electroless plating process for the manufacture of radiation protection suits for pregnant woman: Effect of bending on its electromagnetic shielding performance
Authors: Gui Chengmei , Sun Di , Liu Wenya , Ma Haodong , Chen Zhenming , Li Peng , Huang Junjun
Published: January 2022

Multi-ion fabrics (especially silver ion fabrics) have special advantages as electromagnetic radiation, but the use of noble metals enhances its cost. Electroless nickel plating (EP-Ni) has great potential application in fabricating low-cost metallized material. Here, EP-Ni on pure cotton surface to fabricate radiation protection suits for pregnant woman was established to replace traditional protection suits with silver film. The active groups on the cotton/polyester blend fiber surface could absorb tin and palladium ions, acting as catalytic centers, which can catalyze the reduction of Ni2+ in the plating solution. Ni particle with (111) crystal plane preferential oriented crystal structure deposited on cotton surface with a coarse microstructure. The Ni deposited amount is about 19%. The fabricated material exhibited a shielding effectiveness of 29.5 dB. Studies also shown that bending has no negative effect on crystallinity and electrical property. But more bending times could lead to crack, which would decline electromagnetic shielding performance by 24%.
Serum Metabolomic Analysis of Radiation-Induced Lung Injury in Rats
Authors: Feng Yahui , Gao Yiying , Tu Wenling , Feng Yang , Cao Jianping , Zhang Shuyu
Published: January 2022

Radiation-induced lung injury is a common complication of radiotherapy for lung cancer, breast cancer, esophageal cancer, and thymoma. This study aims to illustrate biomarkers of radiation-induced lung injury and its potential mechanism through the study of metabolomic alterations in serum of Sprague-Dawley rats with different radiation doses. Serum from 0, 10, or 20 Gy irradiated rats were collected and subjected to gas chromatography-mass spectrometry. The result showed that there were 23 dysregulated metabolites between the 10 Gy irradiation group and the 0 Gy control group, whereas 36 preferential metabolites were found between the 20 Gy irradiated rat serum and the control groups. Among them, there were 19 common differential metabolites in the 2 irradiation groups, including 3 downregulated (benzyl thiocyanate, carbazole, and N-formyl-L-methionine) and 16 upregulated metabolites. We further analyzed the metabolic pathways of different metabolites; the results showed that there were 3 significant enrichment pathways in the 10 Gy vs 0 Gy group and 7 significant enrichment pathways in the 20 Gy vs 0 Gy group. Among them, taurine and hypotaurine metabolism, riboflavin metabolism, and glyoxylate and dicarboxylate metabolism were the common metabolic enrichment pathways of the 10 Gy vs 0 Gy group and the 20 Gy vs 0 Gy group.
Arthritis glove provision in rheumatoid arthritis and hand osteoarthritis: A survey of United Kingdom rheumatology occupational therapists
Authors: Hammond Alison , Prior Yeliz
Published: January 2022

Introduction

Hand pain and function limitations are common in rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Provision of arthritis (compression) gloves to relieve hand symptoms is increasing in occupational therapy. Research evaluating arthritis gloves dates to the 1990s, focussing on night-wear of full-length finger gloves in RA. This survey examined glove provision in contemporary clinical practice in the United Kingdom.

Methods

A survey of arthritis glove provision in RA was conducted with Royal College of Occupational Therapists Rheumatology Specialist Section members. A more detailed survey about glove provision in RA and HOA was conducted with rheumatology occupational therapists in North-West England.

Results

Response rates were good, with 60 (73%) therapists responding to the national and 24 (69%) to the regional surveys. Most therapists provided open-finger gloves (commonly IsotonerTM) to about a third of their RA and HOA patients, and to those with any arthritic condition causing significant hand pain and/or swelling. Day-wear was as common as night-wear, and patients were advised to wear these ‘as and when’ for hand symptom relief and support for hand function. They were advised not to wear gloves continually in the day, and regularly perform hand exercises and monitor for potential adverse effects, for example, skin discolouration. Therapists commonly provide replacement gloves as these are often used long-term.

Conclusion

Prescription of arthritis gloves has changed considerably in the last 30 years, with open-finger gloves provided to a wider range of people with arthritis, for a broader range of clinical reasons.
Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica
Authors: Nugraha Ari S. , Purnomo Yoshinta D. , Widhi Pratama Antonius N. , Triatmoko Bawon , Hendra Rudi , Wongso Hendris , Avery Vicky M. , Keller Paul A.
Published: January 2022

Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds to combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into the Indonesian medicinal plants Swietenia mahagoni and Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri- O-caffeoylquinic acid (4) to be the most active against Plasmodium falciparum 3D7 and Dd2 strains with IC50 values of 8.2 and 8.8 µM, respectively. No cytotoxicity was observed against Human Embryonic Kidney cells at a concentration of 40 µM.
Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis
Authors: Kawasumi Tomohiro , Takeno Sachio , Ishino Takashi , Ueda Tsutomu , Hamamoto Takao , Takemoto Kota , Horibe Yuichiro , Takashi Oda
Published: January 2022

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme-2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) as a primary receptor for invasion. Cell entry by the virus requires the co-expression of these molecules in the host cells.

Objective

We investigated ACE2 and TMPRSS2 expression and localization in paranasal epithelium of eosinophilic chronic rhinosinusitis (ECRS) patients (n = 38), non-ECRS (n = 31), and healthy controls (n = 25). CRS inflammatory patterns are characterized by the type of cytokines; we investigated whether inflammatory endotypes are associated with cell-entry molecules, as this could be linked to susceptibility to SARS-CoV-2 infection.

Methods

The ACE2, TMPRSS2, and other inflammatory cytokine mRNA levels were assessed by quantitative RT-PCR. The localizations of ACE2- and TMPRSS2-positive cells were examined with immunofluorescent double-staining using laser scanning confocal microscopy (LSCM).

Results

The non-ECRS patients showed significantly increased ACE2 and TMPRSS2 mRNA expressions compared to the ECRS patients. The CRS patients’ ACE2 and TMPRSS2 mRNA levels were positively correlated with IFN-γ ( r = 0.3227 and r = 0.3264, respectively) and TNF-α ( r = 0.4008, r = 0.3962, respectively). ACE2 and TMPRSS2 were negatively correlated with tissue eosinophils ( r =  −0.3308, r =  −0.3112, respectively), but not with IL-13. ACE2 mRNA levels were positively correlated with TMPRSS2 ( r = 0.7478). ACE2 and TMPRSS2 immunoreactivities were localized mainly in the epithelial ciliated cells, as confirmed by co-staining with TMPRSS2 and acetylated α-tubulin, a cilia organelle marker. Using LSCM imaging, we observed higher expressions of these molecules in the non-ECRS patients versus the ECRS patients.

Conclusion

ECRS patients with type 2 inflammation showed decreased ACE2 and TMPRSS2 expressions in their sinus mucosa. ACE2 and TMPRSS2 regulation seems to be positively related to IFN-γ and TNF-α production in CRS patients; ACE2 and TMPRSS2 were co-expressed in the ciliated epithelium of their paranasal mucosa, implicating the paranasal epithelium as a portal for initial infection and transmission.
A Quantitative and Qualitative Study on Patient and Physician Perceptions of Nephrology Telephone Consultation During COVID-19
Authors: Heyck Lee Seung , Ramondino Sonya , Gallo Kerri , Moist Louise M.
Published: January 2022

Background:

COVID-19 required rapid adoption of virtual modalities to provide care for patients with a chronic disease. Care was initially provided by telephone, which has not been evaluated for its effectiveness by patients and providers. This study reports patients’ and nephrologists’ perceptions and preferences surrounding telephone consultation in a chronic kidney disease (CKD) clinic.

Objective:

To evaluate patient and physician perspectives on the key advantages and disadvantages of telephone consultations in a nephrology out-patient clinic setting.

Design:

Cross-sectional observational survey study.

Setting:

General nephrology clinic and a multidisciplinary kidney care clinic in London, Ontario, Canada.

Participants:

Patients with CKD who were fluent in English and participated in at least one telephone consultation with a nephrologist during the COVID-19 pandemic.

Methods and measurements:

Nephrologists’ and participants’ input facilitated the development of both patient and nephrologist surveys. Participants provided self-reported measures in 5 domains of satisfaction: user experience, technical quality, perceived effectiveness on well-being, perceived usefulness, and effect on interaction. Nephrologists provided self-reported measures within 6 categories: general experience, time management, medication changes, quality of care, job satisfaction, and challenges/strengths. Descriptive statistics were used to present data. Content analysis was performed on 2 open-ended responses.

Results:

Of the 372 participants recruited, 235 participated in the survey (63% response). In all, 79% of the participants were ≥65 years old and 91% were white. Telephone consultation was a comfortable experience for 68%, and 73% felt it to be a safer alternative during the pandemic. Although 65% perceived no changes to health care access, most reported spending less time and fewer resources on transit and parking. Disadvantages to telephone consultation included a lack of physical examination and reduced patient-physician rapport. Eleven of 14 nephrologists were surveyed, with most reporting confidence in the use of telephone consultation. Physician barriers to telephone consultation included challenges with communications and lack of technology to support telephone clinics.

Limitations:

Our survey included a majority of older, white participants, which may not be generalizable to other participants particularly those of other ages and ethnicity.

Conclusion:

Although both patients and nephrologists adapted to telephone consultations, there remain opportunities to further explore populations and situations that would be better facilitated with an in-person visit. Future research in virtual care will require measurement of health care outcomes and economics.

Trial registration:

Not applicable as this was a survey.
Serum Sodium, Patient Symptoms, and Clinical Outcomes in Hospitalized Patients with COVID-19
Authors: Yen Timothy E. , Kim Andy , Benson Maura E. , Ratnaparkhi Saee , Woolley Ann E. , Mc Causland Finnian R.
Published: January 2022

Introduction:

Disorders of serum sodium (SNa) are common in hospitalized patients with COVID-19 and may reflect underlying disease severity. However, the association of SNa with patient-reported outcomes is not clear.

Methods:

The Brigham and Women’s Hospital COVID-19 Registry is a prospective cohort study of consecutively admitted adult patients with confirmed SARS-CoV-2 infection (n = 809). We examined the associations of SNa (continuous and tertiles) on admission with: (1) patient symptoms obtained from detailed chart review; and (2) in-hospital mortality, length of stay, and intensive care unit (ICU) admission using unadjusted and adjusted logistic regression models. Covariates included demographic data and comorbidities.

Results:

Mean age was 60 years, 48% were male, and 35% had diabetes. The most frequent symptoms were cough (64%), fever (60%), and shortness of breath (56%). In adjusted models, higher SNa (per mmol/L) was associated with lower odds of GI symptoms (OR 0.96; 95% CI 0.92-0.99), higher odds of confusion (OR 1.08; 95% CI 1.04-1.13), in-hospital mortality (OR 1.06; 95% CI 1.02-1.11), and ICU admission (OR 1.09; 95% CI 1.05-1.13). The highest sodium tertile (compared with the middle tertile) showed similar associations, in addition to lower odds of either anosmia or ageusia (OR 0.30; 95% CI 0.12-0.74).

Conclusion:

In this prospective cohort study of hospitalized patients with COVID-19, hypernatremia was associated with higher odds of confusion and in-hospital mortality. These findings may aid providers in identifying high-risk patients who warrant closer attention, thereby furthering patient-centered approaches to care.
Are U.S. Professionals and Managers More Left Than Blue-Collar Workers? An Analysis of the General Social Survey, 1974 to 2018
Authors: Brint Steven , Curran Michaela , Mahutga Matthew C.
Published: January 2022

Social science interest in professionals and managers as a left- and liberal-trending stratum has increased in recent years. Using General Social Survey data over a 44-year period, the authors examine 15 attitudes spanning social, economic, and political identity liberalism. On nearly all attitudes, professionals and managers have trended in a liberal direction, have liberalized more quickly than blue-collar workers, and are either as or more liberal than blue-collar workers. The authors find that the higher levels of education among professionals and managers, their tendency to adopt nonauthoritarian outlooks, and their lower propensity to identify with fundamentalist religion mediate their more liberal trends vis-à-vis blue-collar workers. Conversely, their higher relative incomes suppress the extent of their economic and criminal justice liberalism. The authors’ theorization links changes in the macro-economy to growing gaps in the composition of the two strata and the activities of politicians and parties to consolidate emerging political differences.
COVID-19: General Strategies for Herbal Therapies
Authors: Soleymani Samaneh , Naghizadeh Ayeh , Karimi Mehrdad , Zarei Azadeh , Mardi Raefeh , Kordafshari Gholamreza , Esmaealzadeh Niusha , Zargaran Arman
Published: January 2022

The coronavirus disease-2019 (COVID-19) pandemic started in early 2020 with the outbreak of a highly pathogenic human coronavirus. The world is facing a challenge and there is a pressing need for efficient drugs. Plants and natural compounds are a proven rich resource for new drug discovery. Considering the potential of natural products to manage the pandemic, this article was designed to provide an inclusive map of the stages and pathogenetic mechanisms for effective natural products on COVID-19. New drug discovery for the COVID-19 pandemic can encompass both prevention and disease management strategies. Preventive mechanisms that may be considered include boosting the immune response and hand hygiene in the preexposure phase; and blocking of virus binding and entry in the postexposure phase. Potential therapeutic target mechanisms include virus-directed therapies and host-directed therapies. Several medicinal plants and natural products, such as Withania somnifera (L.) Dunal and propolis for prevention; Tanacetum parthenium (L.) for treatment; and Ammoides verticillata (Desf.) Briq and Nigella sativa L. for both prevention and treatment have been found effective and are good targets for future research. The examples of phytochemical compounds that may be effective include aloin and terpenes as anti-septics; isothymol, dithymoquinone, and glycyrrhizin as inhibitors of virus binding and entry; glycyrrhizin, and berberine as replication suppressants; ginsenoside Rg1 and parthenolide as immunomodulators; and eriocitrin, rhoifolin, hesperidin, naringin, rutin, and veronicastroside as anti-complements. Recognizing different mechanisms of fighting against this virus can lead to a more systematic approach in finding natural products and medicinal plants for COVID-19 prevention and treatment.
Vishaghn Dhoop, Nano-Scale Particles with Detoxifying Medicinal Fume, Exhibits Robust Anti-Microbial Activities: Implications of Disinfection Potentials of a Traditional Ayurvedic Air Sterilization Technique
Authors: Balkrishna Acharya , Yagyadev Swami , Vipradev Swami , Singh Kanchan , Varshney Yash , Rastogi Shubhangi , Haldar Swati , Varshney Anurag
Published: January 2022

The rapidly increasing global burden of healthcare associated infections (HAI) is resulting in proportionate increase in chemical disinfection in healthcare settings, adding an extra burden of environmental toxicity. Therefore, alternative disinfection techniques with less or no adverse side-effects need to be explored. In this regard, ayurvedic ‘ dhoopan’ technique involving slow combustion of medicinal herbs, minerals and animal products hold great promise. In this study, dhoopan of a traditionally defined ayurvedic medicinal mix, ‘Vishaghn Dhoop’ (VD) has been assessed for its anti-microbial potentials against both Gram-positive and negative pathogenic bacteria, Mycobacterium and pathogenic fungus, Candida albicans. Fume generated from slow combustion of VD was subjected to physico-chemical characterization and was assessed for anti-microbial effects. VD fume contained particles of 354 ± 84 nm size, laden with anti-microbial metabolites. On agar plates, VD fumigation reduced bacterial growth by 13 - 38%. Liquid culture aeration with VD fume inhibited bacterial growth by 50 - 85%, and fungal growth by 80%. In real life settings (in vivo), un-sanitized rooms fumigated with VD fumes for 30 min reduced the environmental microbial loads by 10 folds. In addition, the safety of VD fumigation was evaluated through in vitro cytotoxicity assay on human lung epithelial (A549) cells. Cells exposed to media-collected VD fumes for 24 h exhibited normal cyto-safety profile. Collectively, these observations provide scientific evidence in support of a traditional technique of disinfection, which can be fine-tuned to have implications in clinical, healthcare and food industry where, disinfection is a prime requirement.
Awareness and understanding among patients about patient safety in India: A cross-sectional questionnaire-based study
Authors: Bhowmick Subhrojyoti , Banerjee Snigdha , Das Saibal , Nath Abhishek , Kundu Debarati , Das Anupam , Das Nina , Ray Krishnangshu , Purkayastha Sujit Kar
Published: January 2022

Background

There is a dearth of studies from India evaluating the awareness of patient safety. This study was performed to gain insight into the Indian patients’ awareness about patient safety and evaluate their willingness in promoting the same.

Methods

In this cross-sectional study, online interactive sessions pertaining to patient safety and patient safety culture were arranged by clinical pharmacologists for 800 urban patients post-discharge from a tertiary care hospital in India. A validated questionnaire was used, and the responses were analysed using descriptive statistics.

Results

A total of 635 patients [mean age, 43.2  ±  10.3 years; 385 (60.6%) males] responded. A total of 93.4% of the patients were aware of the term “patient safety” and 35.3% faced situations where they felt that patient safety was compromised. Of these patients, 64.3% reported to higher authorities when faced with such situations, while the remaining either ignored the issue or had no idea about how to deal with the same. A total of 99.2% of the patients never participated in any patient safety program; nevertheless, 94.5% of them were willing to participate in the same. Accessibility to information about patient care was deemed essential by 58.3% of the patients.

Conclusions

Although the overall awareness about patient safety among urban Indian patients is high, there is a lack of awareness about ways of dealing with patient safety issues. Given the high level of interest in participating in patient safety programs, such programs should routinely include patients for optimizing the chances for safer provision of health care.
The Circular Economy and retail: using Deep Learning to predict business survival
Authors: Uribe-Toril Juan , Ruiz-Real José Luis , Galindo Durán Alejandro C. , Torres Arriaza José Antonio , de Pablo Valenciano Jaime
Published: January 2022

Background

The Circular Economy system can improve the product cycle and changes the system and mentality, both for production and the consumer and has become a significant alternative to the classic economic model. The retail sector has also started to advance along these lines. Following an analysis of the state of the art of the Circular Economy and retailing, using bibliometric techniques, our research focuses on understanding if the relationship between circularity and retailing can help us determine a business’ survivability and resilience. To this end, data pertaining to 658 commercial premises from four cities were studied over a period of 11 years. A Deep Learning technique is applied using Long Short-Term Memory to determine if there is a relationship between the resistance of the selected commercial premises, their status in previous periods of time, the type of business activity, and their classification in the Circular Economy plane.

Results

The system predicts, on the set of tests, with a 93.17% accuracy, the survival of a commercial premises based on the activity, and circularity information before 2012. The results of the training also show very significant precision values of the order of 94.15% with data from the post-depression period.

Conclusions

The results show that businesses with activities related to the Circular Economy are more likely to survive over extended periods of time.
AVL9 promotes colorectal carcinoma cell migration via regulating EGFR expression
Authors: Wu Qiong , Chen Jing De , Zhou Zhuqing
Published: January 2022

Background

Despite advanced treatments could inhibit progression of colorectal carcinoma (CRC), the recurrence and metastasis remain challenging issues. Accumulating evidences implicated that AVL9 played a vital role in human cancers, but it’s biological function and mechanism in CRC remain unclear.

Aim

To investigate the biological role and mechanism of AVL9 in colorectal carcinoma.

Results

AVL9 expression was significantly upregulated in tumor tissues than that in matched normal tissues both at mRNA and protein levels. High expression of AVL9 was closely correlated with M status, stages and poor prognosis of colorectal carcinoma (CRC) patients. Functionally, AVL9 overexpression promoted cell migration rather than cell proliferation in vitro, whereas AVL9 knockdown exhibited the contrary results. Mechanistically, AVL9 regulated EGFR expression, and knockdown of EGFR restrained AVL9-induced cell migration.

Conclusion

These findings demonstrated that AVL9 contributed to CRC cell migration by regulating EGFR expression, suggesting a potential biomarker and treatment target for CRC.
SweepCluster: A SNP clustering tool for detecting gene-specific sweeps in prokaryotes
Authors: Qiu Junhui , Zhou Qi , Ye Weicai , Chen Qianjun , Bao Yun-Juan
Published: January 2022

Background

The gene-specific sweep is a selection process where an advantageous mutation along with the nearby neutral sites in a gene region increases the frequency in the population. It has been demonstrated to play important roles in ecological differentiation or phenotypic divergence in microbial populations. Therefore, identifying gene-specific sweeps in microorganisms will not only provide insights into the evolutionary mechanisms, but also unravel potential genetic markers associated with biological phenotypes. However, current methods were mainly developed for detecting selective sweeps in eukaryotic data of sparse genotypes and are not readily applicable to prokaryotic data. Furthermore, some challenges have not been sufficiently addressed by the methods, such as the low spatial resolution of sweep regions and lack of consideration of the spatial distribution of mutations.

Results

We proposed a novel gene-centric and spatial-aware approach for identifying gene-specific sweeps in prokaryotes and implemented it in a python tool SweepCluster. Our method searches for gene regions with a high level of spatial clustering of pre-selected polymorphisms in genotype datasets assuming a null distribution model of neutral selection. The pre-selection of polymorphisms is based on their genetic signatures, such as elevated population subdivision, excessive linkage disequilibrium, or significant phenotype association. Performance evaluation using simulation data showed that the sensitivity and specificity of the clustering algorithm in SweepCluster is above 90%. The application of SweepCluster in two real datasets from the bacteria Streptococcus pyogenes and Streptococcus suis showed that the impact of pre-selection was dramatic and significantly reduced the uninformative signals. We validated our method using the genotype data from Vibrio cyclitrophicus, the only available dataset of gene-specific sweeps in bacteria, and obtained a concordance rate of 78%. We noted that the concordance rate could be underestimated due to distinct reference genomes and clustering strategies. The application to the human genotype datasets showed that SweepCluster is also applicable to eukaryotic data and is able to recover 80% of a catalog of known sweep regions.

Conclusion

SweepCluster is applicable to a broad category of datasets. It will be valuable for detecting gene-specific sweeps in diverse genotypic data and provide novel insights on adaptive evolution.
Biomedical relation extraction via knowledge-enhanced reading comprehension
Authors: Chen Jing , Hu Baotian , Peng Weihua , Chen Qingcai , Tang Buzhou
Published: January 2022

Background

In biomedical research, chemical and disease relation extraction from unstructured biomedical literature is an essential task. Effective context understanding and knowledge integration are two main research problems in this task. Most work of relation extraction focuses on classification for entity mention pairs. Inspired by the effectiveness of machine reading comprehension (RC) in the respect of context understanding, solving biomedical relation extraction with the RC framework at both intra-sentential and inter-sentential levels is a new topic worthy to be explored. Except for the unstructured biomedical text, many structured knowledge bases (KBs) provide valuable guidance for biomedical relation extraction. Utilizing knowledge in the RC framework is also worthy to be investigated. We propose a knowledge-enhanced reading comprehension (KRC) framework to leverage reading comprehension and prior knowledge for biomedical relation extraction. First, we generate questions for each relation, which reformulates the relation extraction task to a question answering task. Second, based on the RC framework, we integrate knowledge representation through an efficient knowledge-enhanced attention interaction mechanism to guide the biomedical relation extraction.

Results

The proposed model was evaluated on the BioCreative V CDR dataset and CHR dataset. Experiments show that our model achieved a competitive document-level F1 of 71.18% and 93.3%, respectively, compared with other methods.

Conclusion

Result analysis reveals that open-domain reading comprehension data and knowledge representation can help improve biomedical relation extraction in our proposed KRC framework. Our work can encourage more research on bridging reading comprehension and biomedical relation extraction and promote the biomedical relation extraction.