bluuebunny/crossref_metadata_2025 huggingface dataset:
CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data
Authors: Tian Liqing , Li Yongjin , Edmonson Michael N. , Zhou Xin , Newman Scott , McLeod Clay , Thrasher Andrew , Liu Yu , Tang Bo , Rusch Michael C. , Easton John , Ma Jing , Davis Eric , Trull Austyn , Michael J. Robert , Szlachta Karol , Mullighan Charles , Baker Suzanne J. , Downing James R. , Ellison David W. , Zhang Jinghui
Published: May 2020

To discover driver fusions beyond canonical exon-to-exon chimeric transcripts, we develop CICERO, a local assembly-based algorithm that integrates RNA-seq read support with extensive annotation for candidate ranking. CICERO outperforms commonly used methods, achieving a 95% detection rate for 184 independently validated driver fusions including internal tandem duplications and other non-canonical events in 170 pediatric cancer transcriptomes. Re-analysis of TCGA glioblastoma RNA-seq unveils previously unreported kinase fusions (KLHL7-BRAF) and a 13% prevalence of EGFR C-terminal truncation. Accessible via standard or cloud-based implementation, CICERO enhances driver fusion detection for research and precision oncology. The CICERO source code is available at https://github.com/stjude/Cicero.
Digital ecosystems and their implications for competitive strategy
Authors: Subramaniam Mohan
Published: May 2020

This paper discusses some implications for competitive strategy when business environments are framed as digital ecosystems. Digital ecosystems are ecosystems shaped by interdependencies initiated through data connectivity, galvanized by technologies such as sensors and the Internet of Things (IoT). They are composed of two parts: production and consumption ecosystems. Production ecosystems are founded upon interdependencies associated with value chains. Although their underlying interdependencies are traditional, they gain fresh impetus because of data connectivity. Consumption ecosystems on the other hand are spawned by interdependencies among entities that complement the data generated by product usage. These are largely new interdependencies that did not exist before modern digital technologies enabled connectivity. Taken together, digital ecosystems influence a firm’s strategic landscape. I discuss three implications of digital ecosystems for competitive strategy: (1) the scope of value creation, (2) the scope of competition, and (3) the rise of digital monopoly power. I also discuss the implications of digital ecosystems for organizational design and suggest how studies can assess the processes driving the digitization of ecosystems.
A day in the life of a psychiatrist in 2050: reflections on the inaugural Praxis trainees’ section editorial competition
Authors: Bailey Cate
Published: May 2020

The Praxis trainees’ section editor reflects on the inaugural editorial competition, celebrates the winner and shortlist, and shares her own forecast for psychiatry in 2050.
Health Equity, Social Policy, and Promoting Recovery from COVID-19
Authors: Lynch Julia
Published: May 2020

The COVID-19 pandemic has revealed starkly and publicly the close interconnections between social and economic equality, health equity, and population health. To better understand what social policies would best promote population health, economic recovery, and preparedness for future pandemics, one must look both upstream and abroad for inspiration. In this article, the author argues for a suite of near-term and longer-term interventions, including universal health insurance and paid sick leave; upgraded wage insurance policies; tax reform; investments in parental leave, childcare, and education; and upgraded government record systems. Policies that equalize the distribution of the social determinants of health and promote social solidarity also will improve population health and economic performance and allow everyone to confront future pandemics more successfully.
Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification
Authors: Lorberbaum David S. , Kishore Siddharth , Rosselot Carolina , Sarbaugh Dylan , Brooks Elliott P. , Aragon Eloise , Xuan Shouhong , Simon Olivier , Ghosh Debashis , Mendelsohn Cathy , Gadue Paul , Sussel Lori
Published: May 2020

Retinoic acid (RA) signaling is essential for multiple developmental processes, including appropriate pancreas formation from the foregut endoderm. RA is also required to generate pancreatic progenitors from human pluripotent stem cells. However, the role of RA signaling during endocrine specification has not been fully explored. In this study, we demonstrate that disruption of RA signaling within the NEUROG3-expressing endocrine progenitor population impairs mouse β cell differentiation and induces ectopic expression of critical δ cell genes, including Somatostatin. In addition, inhibition of the RA pathway in hESC-derived pancreatic progenitors downstream of NEUROG3 induction impairs INSULIN expression. We further determine that RA-regulation of endocrine cell differentiation is mediated through WNT pathway components. Together, these data demonstrate the importance of RA signaling in endocrine specification and identify conserved mechanisms by which RA signaling directs pancreatic endocrine cell fate.
Nucleocytoplasmic shuttling of the glucocorticoid receptor is influenced by tetratricopeptide repeat-containing proteins
Authors: Mazaira Gisela I. , Echeverria Pablo C. , Galigniana Mario D.
Published: May 2020

It has been demonstrated that tetratricopeptide-repeat (TPR) domain proteins regulate the subcellular localization of glucocorticoid receptor (GR). This study analyses the influence of the TPR domain of high molecular weight immunophilins in the retrograde transport and nuclear retention of GR. Overexpression of the TPR peptide prevented efficient nuclear accumulation of the GR by disrupting the formation of complexes with the dynein-associated immunophilin FKBP52 (also known as FKBP4), the adaptor transporter importin-β1 (KPNB1), the nuclear pore-associated glycoprotein Nup62 and nuclear matrix-associated structures. We also show that nuclear import of GR was impaired, whereas GR nuclear export was enhanced. Interestingly, the CRM1 (exportin-1) inhibitor leptomycin-B abolished the effects of TPR peptide overexpression, although the drug did not inhibit GR nuclear export itself. This indicates the existence of a TPR-domain-dependent mechanism for the export of nuclear proteins. The expression balance of those TPR domain proteins bound to the GR–Hsp90 complex may determine the subcellular localization and nucleocytoplasmic properties of the receptor, and thereby its pleiotropic biological properties in different tissues and cell types.
Proteomic and mechanistic dissection of the poxvirus-customized ribosome
Authors: DiGiuseppe Stephen , Rollins Madeline G. , Astar Helen , Khalatyan Natalia , Savas Jeffrey N. , Walsh Derek
Published: May 2020

Ribosomes are often viewed as protein synthesis machines that lack intrinsic regulatory capacity. However, studies have established that ribosomes can functionally diversify through changes in the composition of, or post-translational modifications to ribosomal subunit proteins (RPs). We recently found that poxviruses phosphorylate unique sites in the RP, Receptor for Activated C Kinase 1 (RACK1) to enhance viral protein synthesis. Here, we developed approaches for large-scale proteomic analysis of ribosomes isolated from cells infected with different viruses. Beyond RACK1, we identified additional phosphorylation events within RPS2 and RPS28 that arise during poxvirus infection, but not other viruses tested. The modified sites lie within unstructured loop domains that position around the mRNA entry and exit channel, respectively, and site-substitution mutants revealed that each modified residue contributed differently to poxvirus replication. Our findings reveal the broader extent to which poxviruses customize host ribosomes and provide new insights into how ribosomes can functionally diversify.
Does contrast-enhanced ultrasound (CEUS) play a better role in diagnosis of breast lesions with calcification? A comparison with MRI
Authors: Pan Jiamin , Tong Wenjuan , Luo Jia , Liang Jinyu , Pan Fushun , Zheng Yanling , Xie Xiaoyan
Published: May 2020

Objective:

To compare the efficacy of contrast-enhanced ultrasound enabled reclassification of Breast Imaging Reporting and Data System (CEUS-BI-RADS) with MRI in the diagnosis of breast lesions with calcification.

Methods:

A total of 52 breast lesions with calcification from 51 patients were detected by ultrasound as hyperechoic foci and categorized as BI-RADS 3–5. The 51 patients further underwent CEUS scan and MRI. The ultrasound-BI-RADS combined with CEUS 5-point score system redefined the classification of BI-RADS which was called CEUS-BI-RADS. The diagnostic efficacy of three methods was assessed by receiver operating characteristic (ROC) curve analysis. Histopathological assessment used as the gold-standard.

Results:

The sensitivities of Ultrasound-BI-RADS, MRI classification of BI-RADS (MRI-BI-RADS) and CEUS-BI-RADS were 85%, 90% and 95% without significant difference among the three modalities (p > 0.05). The diagnostic specificities of ultrasound-BI-RADS, MRI-BI-RADS and CEUS-BI-RADS were 78.1%, 78.1% and 96.8%, respectively (p < 0.05); and the accuracy were 80.7%, 82.6% and 96.1% for ultrasound-BI-RADS, MRI-BI-RADS and CEUS-BI-RADS, respectively (p < 0.05). The area under ROC (AUROC) in differentiation of breast lesions with calcification was 0.945 for CEUS-BI-RADS, 0.907 for MRI-BI-RADS and 0.853 for ultrasound-BI-RADS, with no significant difference among the three modalities (p > 0.05).

Conclusion:

The CEUS-BI-RADS has a better diagnostic efficiency than MRI-BI-RADS in the differentiation of the breast lesions with calcification.

Advances in knowledge:

•CEUS is a better method in differentiation of breast lesions with calcification.

•CEUS-BI-RADS increases the efficiency of diagnosis compared to MRI.
Changing practice: moving to a specialist nurse-led service for BRCA gene testing
Authors: Scott Nicola , O'Sullivan Jackie , Asgeirsson Kristjan , Macmillan Douglas , Wilson Emma
Published: May 2020

Some 5–10% of all breast cancers are associated with a pathogenic variant in a breast cancer-associated gene (BRCA1/BRCA2). Historically, with referral to the Nottingham University Hospitals NHS Trust's clinical genetics department for genetic testing, waiting times were on average 12–14 weeks for an initial appointment and 4–6 months to obtain results from the date of testing. A specialist, nurse-led mainstreaming cancer genetics (MCG) service was set up in the trust's Nottingham Breast Institute (NBI) to: reduce waiting times for the initial consultation, counselling, consent and obtaining results for BRCA1/BRCA2 gene testing; and to ensure appropriate patients with breast cancer were offered genetic testing. Two breast clinical nurse specialists were trained so they could counsel, consent and give results for the BRCA1/BRCA2 gene testing directly to patients. Average waiting times for results from the time of testing were reduced to 35.8 days under the nurse-led service, which enabled oncologists and patients to consider individual treatment options at an earlier time. The MCG service reduced waiting times, resulting in an improved, more streamlined service for patients undergoing genetic testing. The MCG service extended the scope of practice of the breast nurse clinical specialists, embedded an expert advanced nursing role in the breast multidisciplinary team and developed nurse mentoring opportunities.
Advanced optical access technologies for next-generation (5G) mobile networks [Invited]
Authors: Zou Jim (Shihuan) , Adrian Sasu Silviu , Lawin Mirko , Dochhan Annika , Elbers Jörg-Peter , Eiselt Michael
Published: May 2020

Fixed optical transport is the predominant fronthaul technology for 4G
mobile access networks, carrying the traffic between the central
office and subtended antenna sites. With the new functional splits and
related standards introduced in 5G, new capacity and
quality-of-service requirements are imposed on optical transport. In
this paper, we discuss low-cost high-capacity optical fronthaul
solutions enabled by advanced modulation formats and
wavelength-agnostic passive wavelength division multiplexing (WDM)
technology. As the key component, a low-cost remotely tunable WDM
transceiver is introduced, specifically designed on a hybrid
InP-polymer platform. We also explain why an Ethernet-based 5G
fronthaul solution requires additional means to improve the latency
and timing performance of the conventional packet forwarding and
multiplexing. We review the recent standardization effort on
time-sensitive networking in support of 5G fronthaul and present an
FPGA-based implementation providing low latency and low packet delay
variation following the latest IEEE 802.1CM specification. These
advanced technologies can facilitate an effective packet-optical
transport for 5G.
Parity-based, bias-free optical quantum random number generation with min-entropy estimation
Authors: Coleman Mathew R. , Ingalls Kaylin G. , Kavulich John T. , Kemmerly Sawyer J. , Salinas Nicolas C. , Venegas Ramirez Efrain , Schlosshauer Maximilian
Published: May 2020

We describe the generation of sequences of random bits from the parity of photon counts produced by polarization measurements on a polarization-entangled state. The resulting sequences are bias free, pass the applicable tests in the NIST battery of statistical randomness tests, and are shown to be Borel normal, without the need for experimental calibration stages or postprocessing of the output. Because the photon counts are produced in the course of a measurement of the violation of the Clauser–Horne–Shimony–Holt inequality, we are able to concurrently verify the nonclassical nature of the photon statistics and estimate a lower bound on the min-entropy of the bit-generating source. The rate of bit production in our experiment is around 13 bits/s.
Ratiometric pathlength calibration of integrating sphere-based absorption cells
Authors: Bergin S. , Hodgkinson J. , Francis D. , Tatam R. P.
Published: May 2020

Chemical sensors based on optical absorption require accurate knowledge of the optical pathlength of the sample cell. Integrating spheres offer increased pathlengths compared to single pass cells combined with tolerance to misalignment, making them attractive for use in challenging environments subject to vibration. However, the equivalent optical pathlength can be degraded by dirt and / or condensation on the inner surface of the sphere. We present a new scheme for in-situ calibration that uses a ratiometric two-beam approach. Results are presented for an integrating sphere used in the measurement of methane by tunable diode laser spectroscopy (TDLS) at 1651nm. Reduced sphere reflectivity was simulated by applying small areas of black tape on the inner surface. At methane concentrations of 1500ppm and 3125 ppm, for areas of contamination up to 2.3% of the sphere wall, the technique reduced the error from over 50% to within ±4%. At a concentration of 6250 ppm and the most severe fouling corresponding to 2.9% wall coverage, the technique reduced the error from 55-65% to within ±11%.
Rapid super resolution for infrared imagery
Authors: Oz Navot , Sochen Nir , Markovich Oshry , Halamish Ziv , Shpialter-Karol Lena , Klapp Iftach
Published: May 2020

Infrared (IR) imagery is used in agriculture for irrigation monitoring and early detection of disease in plants. The common IR cameras in this field typically have low resolution. This work offers a method to obtain the super-resolution of IR images from low-power devices to enhance plant traits. The method is based on deep learning (DL). Most calculations are done in the low-resolution domain. The results of each layer are aggregated together to allow a better flow of information through the network. This work shows that good results can be achieved using depthwise separable convolution with roughly 300K multiply-accumulate computations (MACs), while state-of-the-art convolutional neural network-based super-resolution algorithms are performed with around 1500K MACs. MTF analysis of the proposed method shows a real ×4 improvement in the spatial resolution of the system, out-preforming the diffraction limit. The method is demonstrated on real agricultural images.
Long-range and wide-band vibration sensing by using phase-sensitive OFDR to interrogate a weak reflector array
Authors: Zhang Zhaopeng , Fan Xinyu , He Zuyuan
Published: May 2020

In this paper, we propose and experimentally demonstrate a novel quasi-distributed fiber-optic vibration sensing system, which can achieve vibration measurement with a wide frequency response over a long distance. The system is based on phase-sensitive optical frequency domain reflectometry (ϕ-OFDR). The sensing part is a single-mode fiber (SMF) with auxiliary weak reflection points along it. By detecting the auxiliary weak reflection points, we can obtain the waveform of the vibration signal. In the experiments, single-point and multi-point vibrations with a wide-frequency response at 100 km are successfully measured, which validated the proposed system. To the best of our knowledge, this is the first time to realize a wide-band vibration waveform measurement over such a long range by using reflectometry-based sensing system.
Time-gated luminescence imaging for background free in vivo tracking of single circulating tumor cells
Authors: Cao Xu , Yao Cuiping , Jiang Shudong , Gunn Jason , Van Namen Austin C. , Bruza Petr , Pogue Brian W.
Published: May 2020

Fluorescence imaging is severely limited by the background and autofluorescence of tissues for in vivo detection of circulating tumor cells (CTCs). Time-gated luminescence (TGL) imaging, in combination with luminescent probes that possess hundreds of microsecond emission lifetimes, can be used to effectively suppress this background, which has predominantly nanosecond lifetimes. This Letter demonstrates the feasibility of TGL imaging using luminescent probes for the in vivo real time imaging and tracking of single CTCs circulating freely in the blood vessels with higher accuracy given by substantially higher signal-to-noise ratio. The luminescent probe used in this Letter was a commercial

E
u

3
+

chelate (EuC) nanosphere with a super-long lifetime of near 800 µs, which enabled TGL imaging to achieve background-free detection with

∼

5

times higher SNR versus steady state. Phantom and in vivo mouse studies indicated that EuC labeled tumor cells moving in medium or bloodstream at the speed of 1–2 mm/s could be captured in real time.
Stitching Together: Participatory textile making as an emerging methodological approach to research
Authors: Shercliff Emma , Holroyd Amy Twigger
Published: May 2020

Arising from a recently formed research network, Stitching Together, this article introduces a collection of case studies that critically examine participatory textile making as an emerging methodological approach to research. The twenty-first-century resurgence of interest in textile processes such as knitting, sewing and weaving, whether as individual practice or community-based initiative, builds on a long and culturally diverse history of collaborative textile-making activity. This resurgence, combined with the familiarity, accessibility and flexibility of textile practices, has influenced a recent growth in the use of such activities as a means of inquiry within diverse research contexts. The article considers the ways in which collective textile-making projects privilege social encounter as a format for learning skills, creating friendships and consolidating shared interests. It goes on to discuss how researchers are drawing on these characteristics when devising new projects, highlighting the quality of experience afforded by textile making, the diverse forms of data generated and the variety of ways in which these participatory activities can be set up. Recognizing that this research approach is far from straightforward, three key methodological themes are then considered: the multifaceted nature of the researcher’s role and the complexities of relationships with participants and other stakeholders; the difficulties that can arise when using such familiar textile processes; and the opportunities, and complexities, of co-producing knowledge with participants through collaborative textile activity.
‘Made with love, filled with hope’. Knitted Knockers and the materiality of care: Their impact on the women who make and receive them
Authors: MacDonald Juliette , Peach Andrea
Published: May 2020

This reflective case study sets out to ask ‘How do participatory textile-making projects engage and impact participants and recipients?’ by focusing on Knitted Knockers UK, a global network of knitters who voluntarily create prosthetics for women following mastectomy or lumpectomy. The article examines the choices women are faced with following breast cancer surgery, and considers ‘softer options’ to surgical reconstruction, including knitted prosthetics. Drawing on qualitative data gathered via personal communications and social media, personal experience of breast cancer diagnosis and treatment, and feminist discourse with relation to breast cancer and the body, the authors evaluate the relationship between well-being, healthcare and digitally connected knitting communities. They offer reflections on the materiality of care the Knitted Knockers represent and consider the role these hand-knitted prosthetics can play in providing a sense of community and emotional well-being for both the creators and the recipients of these knitted gifts.
Weaving and flying: Fusion, friction and flow in collaborative textile research
Authors: Bunn Stephanie
Published: May 2020

Anthropological research is qualitative, emergent, even intuitive. As Ingold proposes, in this regard, it has much in common with arts practice. Anthropologists often follow ‘foreshadowed problems’, joining in with the mundane, interconnected tasks of people’s daily lives in the communities where they are based. Textiles, like other crafts, fit well here, often bringing in ‘women’s work’, domesticity, stories of everyday life and extending across the traditional, the popular, the modern. What this brings (we hope) is texture, quality, a rich description and the voices of our field companions. Collaboration brings an extending and questioning of the boundaries. Where does standard participant observation end and collaboration and making textiles begin? When does practical engagement constitute an intervention? And does intervening, and thus changing local practices in the field, matter? How can collaboration affect the field-site, the textiles and their limits? Who writes the results, whose voices are heard? In my case, early fieldwork ranged from making felt textiles to mundane domestic tasks such as cooking and washing up. But as collaboration, it expanded into sending letters, making work together, cultural exchanges, even symposia. In this article, I draw on case studies from research in Kyrgyzstan and Scotland to explore how collaborations through textile work may (with rigour) enhance inter-community knowledge and communication and produce growth and cumulative understanding.
Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort
Authors: Vasseur Pauline , Dugelay Emmanuelle , Benamouzig Robert , Savoye Guillaume , Hercberg Serge , Touvier Mathilde , Hugot Jean-Pierre , Julia Chantal , Lan Annaïg , Buscail Camille
Published: May 2020

INTRODUCTION:

This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake.

METHODS:

NutriNet-Santé cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC.

RESULTS:

Among the 105,832 participants, 27 reported incident CD and 48 reported incident UC. The relative risks of CD decreased with dietary zinc intakes. Compared with participants with the lowest tertile of zinc intake, the relative risks for CD were 0.60 (95% confidence interval [0.22–1.66]) and 0.12 (95% confidence interval [0.02–0.73]) for the second and the highest tertiles, respectively (P
trend = 0.02). No significant association was observed for UC.

DISCUSSION:

Dietary zinc intake was inversely associated with incident CD.
Os usos do neologismo spoiler no português brasileiro
Authors: Giacomini Botta Mariana
Published: May 2020

A palavra spoiler, do inglês, usada como um alerta sobre a antecipação de fatos importantes da narrativa de obras literárias, audiovisuais ou de vídeo game, está em circulação na variante brasileira da língua portuguesa desde meados de 2004. Isso é o que mostram dados da ferramenta “Google Trends”, registros de dicionários e sites de jornais como “Folha de S. Paulo”, “O Globo”, “O Estado de São Paulo” e “Extra”. Nos últimos anos, observa-se um aumento de popularidade e uma ampliação dos contextos de emprego dessa palavra, caracterizando um processo de adaptação semântica marcado pela polissemia, que assinala sua passagem do estágio de estrangeirismo ao de neologia por empréstimo (ALVES, 2002). É o estudo dessa variabilidade de usos que é apresentada neste artigo, a partir de teorias e conceitos de Guilbert (1974), Alves (2002) e Sablayrolles (2000), entre outros. De acordo com as análises, spoiler está em processo de integração ao léxico do PB e apresenta diferentes tipos de adaptação linguística. Esse neologismo tem comportamento semelhante em outras línguas românicas, como o francês, e o espanhol, o que sugere pistas para pesquisas futuras.
Reseña / Responsabilidad Social Universitaria: el caso del Programa Nacional del Voluntariado Universitario en la UNaM
Authors: Lossio Oscar
Published: May 2020

Se reseña una nueva publicación que aporta a la profundización del conocimiento sobre el Programa Nacional de Voluntariado Universitario, que se crea en el año 2006, en el ámbito de la Secretaría de Políticas Universitarias del Ministerio de Educación de la República Argentina. Precisamente, se considera que la mayor contribución de la obra es la sistematización de valiosa información acerca de dicho programa. Su autora lo analiza en su dimensión de política pública y estudia su implementación en el contexto específico de la Universidad Nacional del Misiones, entre los años 2006 y 2015, recuperando las perspectivas de distintos actores de esa institución. Se recomienda la lectura de este libro que puede ser de utilidad para quienes desarrollan prácticas de voluntariado universitario y para el personal a cargo de la gestión de la extensión.
Polska i polskość w tekstach kultury popularnej (na przykładzie wybranych piosenek)
Authors: Latoch-Zielińska Małgorzata
Published: May 2020

Jednym z kluczowych elementów budowania szacunku dla takich wartości jak patriotyzm, wolność, tolerancja jest poznawanie, czytanie, interpretacja w szkole tekstów, które te wartości reprezentują, bez wykluczania utworów przynależnych do kultury popularnej, która jest tak bliska młodzieży. W artykule przedstawiono wyniki analizy wybranych tekstów z kręgu kultury popularnej (piosenek) w aspekcie funkcjonowania w nich problematyki Polski i polskości. Sformułowane wnioski mogą być pomocne w projektowaniu edukacji nakierowanej na budowanie wielowymiarowej tożsamości młodych ludzi.
Że nienawiść jest… Ojczyzna i obczyzna w kręgu wzajemnych podejrzeń: Stefan Chwin, Srebrzysko, Hieronim Bosch, Niesienie krzyża
Authors: Tomaszewska Grażyna
Published: May 2020

W referacie wykorzystuje się fragment powieści Stefana Chwina Srebrzysko oraz obraz Hieronima Boscha Niesienie krzyża, by poprzez to intertekstualne sąsiedztwo ukazać negatywne i równocześnie potężne źródła wspólnotowości (w tym ojczyźnianej) i związane z tym problemy. Przytoczone teksty mają charakter prowokacyjny, by w przestrzeni lekcyjnej uruchomić pytania, czy rzeczywiście nienawiść jest podstawową siłą spajającą społeczności. A jeśli tak, to w jakim stopniu i jak przełamywać to, co wydaje się „naturalne”, bo powszechne, często niezauważalne, ukrywane za wzniosłymi hasłami, ideami. Według autorki artykułu bez tej etycznej refleksji i uruchomienia podejrzeń wobec naszych dobrych intencji, każda próba budowania wspólnoty opartej na innych zasadach (tj. na zasadach otwartości, tolerancji) będzie mieć charakter pozorowany.
Distinct functions and prognostic values of RORs in gastric cancer
Authors: Gu Feng , Liu Yuming , Liu Yuan , Cheng Shujie , Yang Jihong , Kang Ming , Duan Wendu , Liu Yan
Published: May 2020

Retinoic acid receptor-related orphan receptors (RORs) are frequently abnormally expressed in several human malignancies, including gastric cancer (GC). RORs are involved in the development and progression of GC through Wnt signaling pathway receptors and other common receptors. However, the prognostic roles of individual RORs in patients with GC remain elusive. We accessed the prognostic roles of three RORs (RORα, RORβ, and RORγ) through “The Kaplan–Meier plotter” (KM plotter) database in patients with GC. For all patients with GC who were followed for 20 years, the low mRNA expression of all three RORs showed a significant correlation with better outcomes. We further accessed the prognostic value of individual RORs in different clinical pathological features including Lauren classification, clinical stages, pathological grades, HER2 status, and different treatments methods. The RORs demonstrated critical prognostic roles in GC. Expressions of RORs were higher in GC tissues when compared with normal gastric tissues. Moreover, knockdown of RORs significantly inhibited cell proliferation and migration, suggesting an oncogenic role of RORs in human GC. These findings suggest potential roles of RORs as biomarkers for GC prognosis and as oncogenes in GC.
Two-dimensional flow field distribution characteristics of flocking drainage pipes in tunnel
Authors: Liu Shiyang , Zhang Xuefu , Gao Feng , Wei Liangwen , Liu Qiang , Lü Huoyin , Wang Bo
Published: May 2020

With the rapid development of traffic infrastructure in China, the problem of crystal plugging of tunnel drainage pipes becomes increasingly salient. In order to build a mechanism that is resilient to the crystal plugging of flocking drainage pipes, the present study used the numerical simulation to analyze the two-dimensional flow field distribution characteristics of flocking drainage pipes under different flocking spacings. Then, the results were compared with the laboratory test results. According to the results, the maximum velocity distribution in the flow field of flocking drainage pipes is closely related to the transverse distance h of the fluff, while the longitudinal distance h of the fluff causes little effect; when the transverse distance h of the fluff is less than 6.25D (D refers to the diameter of the fluff), the velocity between the adjacent transverse fluffs will be increased by more than 10%. Moreover, the velocity of the upstream and downstream fluffs will be decreased by 90% compared with that of the inlet; the crystal distribution can be more obvious in the place with larger velocity while it is less at the lower flow rate. The results can provide theoretical support for building a mechanism to deal with and remove the crystallization of flocking drainage pipes.
Pflege durch (nicht-verwandte) Freunde?
Authors: Schobin Janosch
Published: May 2020

Unter den Bedingungen demographischer Schrumpfung, pluralisierter Lebensformen und zunehmender Erwerbsbeteiligung der Frauen spricht alles dafür, den „Pflegemix“ verstärkt durch Pflegeleistungen zu ergänzen, die Freunde erbringen. Studien zur Pflege durch Freunde gibt es jedoch kaum. Der vorliegende Artikel analysiert das Kohortenprofil häuslicher Pflegearrangements durch eine lineare Mehrebenenanalyse der Pflegedaten des Soziooekonomischen Panels (SOEP) der Jahre 2000–2013. Die Analyse zeigt, dass freundschaftsgestützte Pflegearrangements bei Gepflegten zunehmen, die 1938 oder später geboren wurden. Im Gegensatz hierzu nehmen häusliche Pflegearrangements, in denen ausschließlich Freunde pflegen, nicht in jüngeren Kohorten zu. Des Weiteren analysiert der Beitrag die Pflegeerwartungen an Freunde anhand der Daten des SOEP aus dem Jahr 2011. Hier zeigt sich, dass 1) Pflegeerwartungen primär an kommunikativ intime Freunde adressiert sind, dass 2) Personen ohne Nach- und Vorfahren mit einer besonders hohen Wahrscheinlichkeit Pflege von Freunden erwarten und dass 3) es einen geschlechtsspezifischen Geschlechtshomogenitätseffekt für die Nominierung von Freunden als potenzielle Pfleger gibt. Der Artikel schließt mit einer Diskussion der Forschungslücken in der aktuellen Literatur zur Pflege durch Freunde und plädiert für eine stärker freundschaftssoziologisch informierte Forschung informeller Pflegearrangements.
Worry-Nostalgia: Anxieties around the Fading of Local Cuisines and Foodways
Authors: Trainer Sarah , Hardin Jessica , SturtzSreetharan Cindi , Brewis Alexandra
Published: May 2020

Worry-nostalgia is a particular iteration of felt anxiety that certain material things and ways of being in the world are slipping away. We suggest that this particular shade of place-based nostalgia, expressed through stress, anxiety, and worry, comes from broader concerns about individual and community health, weight, and well-being, as well as from longing for the relations that made certain foods seem naturally embedded in a particular community and rooted in a specific landscape. We consider and compare three very different ethnographic contexts—suburban parts of Osaka, Japan; peri-urban Atlanta, Georgia, in the United States; and the peri-urban areas around the capital city of Apia, Samoa—to explore the intersection of memory and distress around what people eat and what they think they should eat, in the context of local cuisines that are believed to be fading. This parallel analysis of narratives reveals commonalities in how sense of loss is characterized, highlighting a shared experience of worry-nostalgia generated from the shifting wider global foodscape.
HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: New and future perspectives for parathyroid carcinoma
Authors: Perrier Nancy D , Arnold Andrew , Costa-Guda Jessica , Busaidy Naifa L , Nguyen Ha , Chuang Hubert H , Brandi Maria Luisa
Published: May 2020

This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27–29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer was constituted by the Steering Committee to address key questions in the field. The objectives were to recap open forum discussion of interested parties from multiple disciplines. The expert panel met in a closed session to consult on the data to be highlighted on the evidence-based results and on the future directions. Preceding the Conference, members of the expert panel conducted an extensive literature search. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature. Questions were developed by the expert panel on parathyroid carcinoma. A comprehensive literature search for relevant studies was undertaken. This report represents the expert panel’s synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of parathyroid carcinoma. This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of parathyroid carcinoma.
La hiperdiversificación de Physeteroidea (Cetacea: Mammalia) del Mioceno tardío en el Pacifico Sur, nuevos fósiles del área de Sacaco, Arequipa, Perú
Authors: Benites-Palomino Aldo , Urbina Mario
Published: May 2020

Los cachalotes (Physeteroidea) son un grupo de cetáceos con una ecología restringida en la actualidad. Las tres especies actuales son el remanente de un grupo que alcanzó su máxima diversificacion durante el Mioceno, incluyendo cinco especies simpátricas descritas en la Formación Pisco, Ica-Arequipa, Perú. Entre estas se incluyen formas piscívoras, bénticas, así como carnívoros de tamaño medio e hipercarnívoros. Se reportan dos dientes aislados provenientes del Mioceno superior de las localidades de Sacaco y Sacaco sur, que corresponden con la morfología típica de Physeteridae. Esta morfología dentaria es similar a la de taxones presentes en el hemisferio norte como Orycterocetus o Aulophyseter del Mioceno medio. Debido a esto se presume que los restos corresponderían a physetéridos con hábitos piscívoros, que quizás poseyeron un desarrollo incipiente de la capacidad de succión. La presencia de este linaje indicaría que a fines del Mioceno los parientes de los modernos Physeter y Kogia compartieron el mar peruano con formas extintas, sin solapamiento de nichos debido a la morfología altamente derivada de cada grupo. Este nuevo registro expande la comunidad de cetáceos fósiles de Sacaco, que se vio favorecida por la gran diversidad de ambientes poco profundos que dominaron el litoral peruano hasta el establecimiento final del Sistema Humboldt.
The mechanism of after-runner storm surge along the Northern coast of Vietnam
Authors: Thuy Nguyen Ba
Published: May 2020

In this study, the mechanism of sea level rise along the Northern coast of Vietnam after the landfall of the Typhoon Kalmaegi (September/2014) at Quang Ninh province was analyzed based on the observation data and the results of a coupled model of surge, wave and tide (called SuWAT), by using asymmetric and symmetric wind and pressure fields. For the asymmetric wind and pressure field, the Weather Research and Forecasting (WRF) model was used, while for the symmetric wind and pressure field, a parametric wind and pressure model was used. In the case using wind fields from the WRF model, the case that did not consider the effect of tail wind field after the typhoon landfall was also conducted in order to assess the role of the wind field before and after the typhoon landfall on the surge. The results showed that the case using wind and pressure field from the WRF model showed better agreement with observation data, because the WRF model well simulated the wind and pressure field before and after the typhoon landfall. The strong tail wind mainly caused the high surge in the area. This research result will be useful in warning and forecasting storm surges in the area.
Nonequidistant two-dimensional antenna arrays are based on Latin squares for registration of cosmic, atmospheric and lithospheric radiation
Authors: Anh Nguyen Xuan , Lutsenko V. I. , Yiyang Luo , Popov I. V.
Published: May 2020

The possibility of using Latin squares for constructing two-dimensional non-equidistant antenna arrays that can be used for development of radio telescopes and systems for remote sensing of atmospheric and lithospheric radiation has been shown. An algorithm for calculating the coordinates of elements of a non-equidistant antenna array using the values of elements of Latin squares is proposed. It is shown that in this case, it is possible to obtain an almost complete coverage of the grid of spatial frequencies in the region of the arrangement of the elements at small filling coefficients of array. Directional patterns are studied and the side lobes levels are estimated for non-equidistant antennas obtained on the basis of Latin squares. The possibility of synthesizing of large antenna arrays on the basis of composite squares using the embedding of generative Latin squares is shown. The characteristics of the obtained arrays are studied. It is shown that using the shifts and mutual rotations of individual layers is involved in the synthesized array; its characteristics can be substantially improved.
Investigation of microtremor motion variation by Nakamura’S H/V spectral ratio method
Authors: Tien Hung Nguyen - , Nguyen-Hong Phuong , Nguyen-Le Minh , Kuo-Liang Wen , Tran-An Nguyen
Published: May 2020

In this study, the variation of microtremor motion is investigated using observation data in Hanoi and Vung Tau cities. The results of observation conducted by times and by seismometers are processed using the Nakamura's H/V spectral ratio method and compared. For investigation, the observations have been conducted with frequency of 27 observations per hour, 22 observations per month, 4 simultaneous observations using both Servo and K2 seismometers, and 12 simultaneous observation using 7 Servo seismometers. The results of data analysis show that the values of dominant frequency and shapes of the H/V spectral ratio obtained are similar in the frequency range from 0.4 Hz to 5 Hz, especially on the dominant frequency domain. The results confirm that the microtremor variation observations can be carried out with one observation time or by multiple seismometers.
Seismic hazard assessment and local site effect evaluation in Hanoi, Vietnam
Authors: Duong Nguyen Anh , Nguyen Pham Dinh , Tuan Vu Minh , Duan Bui Van , Linh Nguyen Thuy
Published: May 2020

In this study, we have carried out the probabilistic seismic hazard analysis in Hanoi based on the latest seismotectonic data. The seismic hazard map shows peak ground acceleration values on rock corresponding to the 10% probability of exceedance in a 50-year time period (approximately return periods of 500 years). The calculated results reveal that the maximum ground acceleration can occur on rock in Hanoi is about 0.13 g corresponding to the shaking intensity level of VIII on the MSK-64 scale. The ground motion values calculated on rock vary according to the local site conditions. We have evaluated and corrected the local site effects on ground motion in Ha Dong district, Hanoi by using microtremor and borehole data. The Nakamura’s H/V spectral ratio method has been applied to establish a map of ground dominant periods in Ha Dong with a TS range of 0.6 - 1.2 seconds. The relatively high values of periods indicate that Ha Dong has soft soil and thick Quaternary sediments. The sediment thickness in Ha Dong is calculated to vary between 30 - 75 m based on ground dominant periods and shear wave velocity VS30 = 171 - 254 m/s. The results of local site effect on ground motion show that the 500-year return period peak ground acceleration in Ha Dong ranges from 0.13 g to 0.17 g. It is once again asserted that the seismic hazard in Hanoi is a matter of great concern, due not only to the relatively high ground acceleration, but also to the seismic characteristics of soil (low shear wave velocity, ground dominant period of approximately 1 second).
Gravity terrain correction for mainland territory of Vietnam
Authors: Hung Pham Nam , Trieu Cao Dinh , Dung Le Van , Quang Phan Thanh , Cuong Nguyen Dac
Published: May 2020

Terrain corrections for gravity data are a critical concern in rugged topography, because the magnitude of the corrections may be largely relative to the anomalies of interest. That is also important to determine the inner and outer radii beyond which the terrain effect can be neglected. Classical methods such as Lucaptrenco, Beriozkin and Prisivanco are indeed too slow with radius correction and are not extended while methods based on the Nagy’s and Kane’s are usually too approximate for the required accuracy. In order to achieve 0.1 mGal accuracy in terrain correction for mainland territory of Vietnam and reduce the computing time, the best inner and outer radii for terrain correction computation are 2 km and 70 km respectively. The results show that in nearly a half of the Vietnam territory, the terrain correction values ≥ 10 mGal, the corrections are smaller in the plain areas (less than 2 mGal) and higher in the mountainous region, in particular the correction reaches approximately 21 mGal in some locations of northern mountainous region. The complete Bouguer gravity map of mainland territory of Vietnam is reproduced based on the full terrain correction introduced in this paper.
Impact of sand mining on sediment transport and morphological change of Hai Phong coastal area
Authors: Hai Nguyen Minh , Khanh Do Gia , Vinh Vu Duy , Lan Tran Dinh
Published: May 2020

The paper presents the results of simulating the impact of sand mining on sediment transport and morphological change in Hai Phong coastal area based on Delft3D model. Scenario groups are established: Present scenarios without sand mining and simulated scenarios of the present sand mining (assuming 30% sand compared to plan). The scenario groups are calculated in the dry and rainy seasons for main wind directions (NE, SE, SW) in the case of moderate wind and strong wind. The results show that sand mining reduces sediment flow alongshore (2–81%) and seawards (5–83%). Besides, the increase in depth causes morphological change in this area: Rising the deposition rate (5–10 mm/month) at the sand mining locations; decreasing accretion rate and increasing the erosion rate in the neighboring areas of sand mining location.
Rip current simulation on some beaches in coastal Quang Nam province
Authors: Cong Nguyen Chi , Mau Le Dinh , Tuan Nguyen Van , Dung Nguyen Thi Thuy , Bac Phan Thanh , Hoan Pham Sy , Binh Tran Van
Published: May 2020

This paper presents modelling results of rip currents on the main beaches along coastal Quang Nam province including Ha My, Binh Minh, Tam Thanh and Rang beaches during two typical wind seasons: Northeast monsoon (Northeast wind direction, wind levels: 4, 5, 6) and Southwest monsoon (Southeast wind direction, wind levels: 4, 5) using Mike 21 model. Calculation results show that during the Northeast monsoon, the rip current formed in all beaches. In the scenario of level 4 of wind speed, average rip speed was about 40–50 cm/s. In particular, at Tam Thanh beach area, the rip was a typical one with the components such as feeder current, rip neck and rip head. With the level 5 of wind field, the formation of the rip was clearer, the speed of the rip was stronger, average value was about 50–60 cm/s. Meanwhile, with the level 6 of wind field, the typical rip structure was broken, creating local eddies or longshore currents at some positions, but strengthened at other positions. During the Southwest monsoon, the rip current did not form at the beaches and the longshore currents were dominant.
Some results of research and forecasting of groundwater salinization in the coastal zone of Soc Trang province
Authors: Nhan Nguyen Thi , Trung Dang Tran , Anh Bui Thi Bao , Tung Nguyen Xuan , Thanh Nguyen Xuan
Published: May 2020

In recent years, the situation of salinity intrusion is very complicated and becomes more serious in the coastal area of Soc Trang province. In this research, SEAWAT modified water density flow model was used to forecast the salinity intrusion for Holocene aquifer (qh) and upper Pleistocene aquifer (qp3) according to the water use planning scenario. The results show that the impact of groundwater extraction process increases the TDS content in the aquifer, the salt water/fresh water areas change over time, the trend of salinity change increases. In Holocene aquifer, salt water area is relatively large and the TDS concentration increases towards the sea, however, fresh water area changes inconsiderably: In 2015 accounting for 17.42% and by 2030 accounting for 17.77% of aquifer area. In upper Pleistocene aquifer, the fresh water area declines significantly: In 2015 accounting for 9.35% and by 2030 only accounting for 7.53% of aquifer area.