bluuebunny/crossref_metadata_2025 huggingface dataset:
The Evolutions and Large-scale Mechanisms of Summer Stratospheric Ozone Intrusion across Global Hotspots
Authors: Lee Jae Won , Wu Yutian , Wang Xinyue
Published: September 2023

Stratospheric ozone intrusions have a significant impact on surface
ozone levels. Especially in summer, intrusions can contribute to extreme
ozone events because of preexisting high ozone levels near the surface
and cause serious health issues. Considering the increasing trend of
surface ozone level, an understanding of stratospheric ozone intrusion
is necessary. Previous studies mainly focused on the case studies, and
general knowledge of the spatial structure and large-scale dynamics
underlying these intrusions is lacking. Thus, based on the Whole
Atmosphere Community Climate Model, version 6 (WACCM6) simulation and a
stratospheric origin ozone tracer, we identify the global hotspots of
stratospheric intrusions: North America, Africa, the Mediterranean, and
the Middle East, and investigate the underlying large-scale mechanisms.
From the trajectory analysis, we find that the upper-level jet drives
isentropic mixing near the jet axis and initiates stratospheric ozone
intrusion. Subsequently, climatological descent at the lower troposphere
brings the ozone down to the surface, which explains the spatial
preference of summertime stratospheric intrusion events. Apart from
others, the Middle East shows a relatively fast descent, likely related
to the Asian summer monsoon circulation.
UNetKF: Ensemble U-Net Kalman Filter
Authors: Lu Feiyu
Published: September 2023

Machine learning techniques have seen a tremendous rise in popularity in
weather and climate sciences. Data assimilation (DA), which combines
observations and numerical models, has great potential to incorporate
machine learning and artificial intelligence (ML/AI) techniques. In this
paper, we use U-Net, a type of convolutional neutral network (CNN), to
predict the ensemble covariances in the Ensemble Kalman Filter (EnKF)
algorithm.

Using a 2-layer quasi-geostrophic model, U-Nets are trained using data
from existing EnKF systems. The U-Nets are then used to predict the
flow-dependent covariance matrices in U-Net Kalman Filter (UNetKF)
experiments, which are compared to traditional 3-dimensional variational
(3DVar) and EnKF methods. The performance of UNetKF can match or exceed
that of 3DVar, or EnKF with ensemble sizes up to 80. We also demonstrate
that trained U-Nets can be transferred to a higher-resolution model for
UNetKF, which again performs competitively to 3DVar and EnKF,
particularly for small ensemble sizes.
Observations of hydrodynamic processes on atolls in the South China Sea with deep reef flats (> 10m) with implications for sediment transport potential
Authors: Li Jin , Ashton Andrew Dale , Gao Shu , Wang Ya Ping , Xu Xiaomei
Published: September 2023

The Nansha Islands comprise the largest atoll archipelago in the South
China Sea, accommodating 15% of global atolls. In contrast to reef
flats found elsewhere in the Indo-Pacific region that typically have
grown close to modern sea level, a considerable portion of atoll rims
there are composed of 10-20-m-deep reef flats. To better understand
modern processes, particularly whether these deep reefs are host to
modern physical reworking or instead may be relict features abandoned by
sea-level rise, we conducted a mooring hydrodynamic observation from
January to September on a 12-m-deep southwest-facing reef flat. These
measurements show a predominance of seasonally-varying waves and stable,
moderate tide-driven currents, similar to short-term observations at
three adjacent deep-reef-flats. While the reef flat was protected from
the northeast monsoon from January to May, the southwest monsoon from
June to September caused prolonged exposure to large waves (mean Hs of
1.3 m; orbital velocity 0.22 m/s) and consistent cross-flat currents
(0.08 m/s on average), resulting in near-bed skin-friction shear
velocities of 0.02 m/s on average. These wave conditions are capable of
forming and mobilizing bed ripples while entraining coarse coral sand
(d50 = 1 mm) for over half a year. Estimates of potential sediment flux
suggest the capability for combined waves and advective currents to
deflate the 12-m-deep reef rim by up to 28 mm in 8 months. As these
potential losses are similar to reef accretion rates, our measurements
imply that modern processes could play a significant role in the
maintenance of deep reef flats.
Two classes of equatorial magnetotail dipolarization fronts observed by Magnetospheric Multiscale Mission: A statistical overview
Authors: Qeeq Soboh Wajih Al , Contel Olivier Le , CANU Patrick , Retinò Alessandro , Chust Thomas , Mirioni Laurent , Chuvatin A. , Nakamura Rumi , Ahmadi Narges , Wilder Frederick , Gershman Daniel J , Khotyaintsev Yuri V. , Lindqvist Per-Arne , Ergun Robert E , Burch James L , Torbert Roy B. , Fuselier Stephen A. , Russell Christopher T. , Wei H. Y. , Strangeway Robert J. , Bromund Kenneth R , Fischer David , Giles Barbara L. , Saito Yasuyuki
Published: September 2023

We carried out a statistical study of equatorial dipolarization fronts
(DFs) detected by the Magnetospheric Multiscale mission (MMS) during the
full 2017 Earth’s magnetotail season. We found that two DF classes are
distinguished: class I (74.4%) corresponds to the standard DF
properties and energy dissipation and a new class II (25.6%). This new
class includes the six DF discussed in Alqeeq et al. (2022) and
corresponds to a bump of the magnetic field associated with a minimum in
the ion and electron pressures and a reversal of the energy conversion
process. The possible origin of this second class is discussed. Both DF
classes show that the energy conversion process in the spacecraft frame
is driven by the diamagnetic current dominated by the ion pressure
gradient. In the fluid frame, it is driven by the electron pressure
gradient. In addition, we have shown that the energy conversion
processes are not homogeneous at the electron scale mostly due to the
variations of the electric fields for both DF classes.
Free infragravity waves on the inner shelf: Observations and Parameterizations at two Southern California beaches
Authors: Lange Athina MZ , Fiedler Julia W , Merrifield Mark A. , Guza R.T.
Published: September 2023

Co-located pressure and velocity observations in 10-15m depth are used
to estimate the relative contribution of bound and free infragravity
(IG) wave energy to the IG wave field. Shoreward and seaward going IG
waves are analyzed separately. At the Southern California sites,
shoreward propagating IG waves are dominated by free waves, with the
bound wave energy fraction <30% for moderate energy incident
sea-swell and <10% for low energy incident sea-swell. Only
the 5% of records with energetic long swell show primarily bound waves.
Consistent with bound IG wave theory, the energy scales as the square
(frequency integrated) sea-swell energy, with a higher correlation with
swell than sea energy. Seaward and shoreward free IG energy is strongly
tidally modulated. The ratio of free seaward to shoreward propagating IG
energy suggests between 50-100% of the energy radiated offshore is
trapped on the shelf seaward of 10-15m and redirected shoreward. Remote
sources of IG energy are small. The observed linear dependency of free
seaward and shoreward IG energy on local sea-swell wave energy and tide
are parameterized with good skill (R2 ~ 0.90). Free
(random phase) and bound (phase-coupled) IG waves are included in
numerically simulated timeseries for shoreward IG waves that are used to
initialize (~ 10m depth) the numerical nonlinear wave
transformation SWASH. On the low slope study beach, wave runup is only
weakly influenced by free shoreward propagating waves observed at the
offshore boundary (foreshore slope = 0.02).
Negatif Poisson Oranındaki Stent Tasarımının Üç Katmanlı Arter ve Asimetrik Plak Yapısına Göre Sanki-Statik Analizi
Authors: Erdoğuş Hakan Burçin
Published: September 2023

Biyobozunur stent tasarımlarında eğrisel strat formunda açık hücre modelleri yüksek kısalma oranı ve uç açılması nedeniyle yüksek damar hasarı oluşturmaktadır. Arterde oluşan hasarın erken dönemde stent içi daralmaya ve stentin kaymasına sebep olduğundan geometrik yenilikler sayesinde dezavantajlı durumun giderilebileceği belirtilmektedir. Negatif Poisson oranına (NPR) sahip olan stent tasarımlarında minimum oranda kısalma oranı sağlanmaktadır. Bununla birlikte stent genişlemesinde uç açılması oluşmamaktadır. Bu çalışmada, çeper doğrultusunda dört öksetik geometri olarak tasarlanan NPR stent için stent-arter kaplama oranı % 26,3 olarak belirlenmiştir. NPR stentin asimetrik plak içeren üç katmanlı arter yapısı içerisinde dört aşamalı olarak sayısal analizi gerçekleştirilmiştir. PLLA malzeme modelinde yüksek akma dayanımı ve düşük strat kalınlığındaki NPR stent için yapılan analizlerde, kısalma oranı % 12 ve geri daralma oranı % 1,19 olarak elde edilmiştir. Absorb BVS eğrisel tasarımla kıyaslandığında % 10 daha düşük miktarda uzunlamasına yer değiştirme elde edildiğinden, stentin arter duvarındaki konumlanması iyileştirilmiştir.
Digitale Nachweise und europäische Interoperabilität – eine Herausforderung für das Projektmanagement der Zukunft
Authors: Bacharach Guido
Published: September 2023

Wie einfach wäre es, Zeugnisse und andere Nachweise digital zu erhalten und verarbeiten zu können! Im Rahmen der Digitalisierung im öffentlichen Dienst wird dieser Traum in einigen deutschen wie auch europäischen Projekten soeben realisiert. Doch der Einsatz einer solchen digitalen Technik bedingt auch Changeprojekte im rechtlichen und organisatorischen Umfeld – und das gleich für ein nationales wie internationales Umfeld verschiedenster Rechts- und Organisationssysteme. Ein komplexes System von bedingten Änderungen, die eine große Herausforderungen im Multiprojektmanagement in der nahen Zukunft darstellen werden. Interoperabilität, gerade bei digitalen Nachweisen, ist ein momentan heißes Thema im europäischen Umfeld und könnte eine Lösung für diese Aufgabe sein. Der Artikel beschreibt beispielhafte Projekte, aktuelle Initiativen und mögliche zukünftige Entwicklungen.
Validation des seuils cliniques dans la version remplie par les parents du Questionnaire sur les points forts et les points faibles au sein d’un vaste échantillon d’enfants et de jeunes canadiens
Authors: Turner Sarah E. , Dopko Raelyne L. , Goldfield Gary , Cloutier Paula , Pajer Kathleen , Abdessemed Mohcene , Mougharbel Fatima , Ranney Michael , Hoffmann Matt D. , Lang Justin J.
Published: September 2023

Introduction

Le Questionnaire sur les points forts et les points faibles (Strengths and Difficulties Questionnaire, ou SDQ), qui permet d’évaluer les difficultés comportementales et émotionnelles, est un outil de dépistage des problèmes de santé mentale utilisé dans plusieurs pays. Notre objectif était de valider les seuils (cut-points) actuels, britanniques, du SDQ au sein d’un échantillon d’enfants et de jeunes canadiens et, au besoin, de fixer de nouveaux seuils canadiens pour le SDQ.

Méthodologie

Cette étude est fondée sur les données d’enfants et de jeunes de 6 à 17 ans provenant de l’Enquête canadienne sur les mesures de la santé (n = 3 435) et de dossiers de consultations externes du Centre hospitalier pour enfants de l’est de l’Ontario (n = 1 075). Nous avons recueilli les données issues du SDQ rempli par les parents. Nous avons ajusté les seuils actuels du SDQ à l’aide d’une approche fondée sur la distribution et d’une approche par courbe ROC (Receiver Operating Characteristic, ou courbe caractéristique de la performance d’un test). Nous avons ensuite calculé, à l’aide de ces deux méthodes analytiques, la sensibilité, la spécificité et le rapport de cotes diagnostique des seuils cliniques actuels et des nouveaux seuils cliniques du SDQ afin de déterminer si de nouveaux seuils offriraient une meilleure utilité clinique.

Résultats

Les données recueillies révèlent des différences entre les seuils cliniques britanniques et les seuils cliniques canadiens en matière d’efficacité de dépistage. L’utilisation des valeurs canadiennes obtenues à l’aide de la technique fondée sur la distribution a permis de maximiser la spécificité, c’est-à-dire qu’elle a permis d’améliorer la probabilité de détecter les vrais négatifs. Le score total au SDQ atteignait le seuil d’utilité clinique (rapport de cotes diagnostiques > 20) tant avec les seuils actuels qu’avec les nouveaux seuils, mais les échelles individuelles n’atteignaient pas ce seuil d’utilité clinique, et ce, avec aucun des deux seuils.

Conclusion

Les chercheurs canadiens travaillant avec le SDQ devraient tenir compte à la fois des nouveaux seuils calculés avec notre population à l’étude et des seuils britanniques afin de permettre les comparaisons au fil du temps et entre pays.
MUJER Y MEDICINA, Dr. Juan Riera Palmero, Editorial de los Anales 2019.
Authors: Riera Palmero Juan
Published: September 2023

En la actualidad los estudios de género se han multiplicado, siendo una nueva línea de investigación, sociológica, antropológica, histórica y legislativa con honda dimensión política. El volumen de publicaciones, libros, monografías y revistas especializadas sobre la historia de la mujer se halla en auge creciente.
BUDAYA DAN BAHASA KELUARGA MULTI-SUKU DI KELURAHAN NARAM KOTA SINGKAWANG
Authors: Farenti Sheila Aisyah
Published: September 2023

In Indonesia, there are many tribes including the Malay, Javanese, Batak, Sundanese, Dayak and many more. Each tribe has its own culture and language. Then the culture develops and experiences some renewal in traditions or customs. The Malay tribe and the Javanese tribe really uphold, appreciate and respect existing customs. At present, the Malay and Javanese tribes are still very attached to the customs that have been created since long ago even though there are updates and decreases. The culture or tradition that is still carried out today is Saprahan in the Malay tribe and Kenduri in the Javanese tribe. This research was conducted to find out the culture and language found in multi-tribe families. This research method uses qualitative methods with interview and observation techniques in multi-tribe families to collect research data. So from this research it is known that the culture of the Malay and Javanese tribes is still carried out today and has experienced renewal and decline. From the renewal and decline, there is an influence on both tribes such as the existence of culturation and the replacement of a tradition. For language use, it is influenced by environmental factors. Therefore, it is important to maintain the culture and language that has been produced by the ancestors in order to remain a self-identity.
A dimensão da afetividade identitária: literatura, língua e normas ortográficas na Galiza. Uma proposta de aproximação
Authors: Torres Feijó Elias José
Published: September 2023

O presente trabalho propõe tomar em consideração a componente afetiva na construção identitária individual e coletiva. São formulados os conceitos de identidade afetivizada (a assunção sentimental de elementos identitários: o elemento identitário gera afetividade) e afetividade identitária (o resultado numa identidade a partir dum elemento ou duns elementos mediadores não necessariamente vinculados de modo linear com o objeto da identificação). Aplica-se em concreto à questão ortográfica no caso galego e como essas componentes podem incidir nas elaborações afetivas das pessoas em relação à conceção da língua, à literatura e aos afetos e orientações de leitura; e como essas orientações se relacionam com o próprio conceito de nação e das suas relações externas.
Leitura literária como performance e o circuito dos afetos na biblioteca
Authors: Chiari Gisele Gemmi
Published: September 2023

O artigo a seguir apresenta algumas reflexões sobre quais seriam os objetivos e perspectivas das práticas de leitura literária hoje a partir da realização do projeto “Itinerários de Leitura Literária e o circuito dos afetos na biblioteca”, e considerando a obra de Paul Zumthor acerca da relação entre performance, recepção e leitura e as proposições do filósofo Vladimir Safatle a respeito de como os afetos criam vínculos e organizam o tecido social. Dito de outra maneira, a partir de uma noção amplificada do termo performance, no sentido da percepção e recepção da literatura no momento em que ela é presentificada no ato de leitura ou de escuta, propõe-se pensar como a prática da leitura literária pode ensejar dinâmicas sociais de transformação, do circuito dos afetos, ocasionadas pela fruição poética tendo como base o que foi experienciado nos encontros com as bibliotecárias e bibliotecários, dentre outros colaboradores, das bibliotecas públicas do município de Londrina durante o desenvolvimento do projeto.
Mia Couto: uma escrita na voz – aprendendo com a chuva...
Authors: Pereira José Paulo
Published: September 2023

A nossa leitura de Um rio chamado tempo, uma casa chamada terra, da autoria de Mia Couto, tem o seu foco na conceção de escrita que, da singular correspondência entre as personagens do Avô Dito Mariano e Mariano, o neto que lhe herda o nome, se desprende. A nossa questão condutora refere-se, por um lado, à dupla inscrição de Dito Mariano, a respeito dessa escrita: simultaneamente por fora – sendo ele analfabeto... – e por dentro – mas num sentido que julgamos derrideano. As premissas da noção de escrita de Mia Couto, expostas em E se Obama fosse africano? são, por seu lado, compatíveis, com as posições de Jacques Derrida, contidas em livros como Posições, De la grammatologie, Marges – de la philosphie ou Points de suspension sobre uma certa escrita na voz, uma arqui-escrita que nos deve ajudar a reconsiderar a posição da oralidade, na sua diferença em relação à escrita corrente.
Loucura e velhice na poética da derrelição: notas sobre A obscena Senhora D, de Hilda Hilst
Authors: Almeida Tereza Virginia de
Published: September 2023

A obscena Senhora D, de Hilda Hilst, tem como personagem central Hillé, uma viúva de sessenta anos que decide morar no vão da escada de sua casa, de onde fala com o marido e o pai já mortos, ouve vozes de dentro da parede e assusta a vizinhança com máscaras de papel. O artigo, dedicado a esta obra de Hilst, aborda o entrelaçamento entre velhice e loucura na definição de um espaço de exclusão a partir do qual a personagem experiencia uma singular relação com a linguagem. Trata-se não somente do constante contato com o tema da morte, mas também da experimentação em torno da palavra da qual deriva uma estética singular, uma poética, a poética da derrelição.
Ancestralidade e autoestima em Maréia, de Miriam Alves
Authors: Santos Luciana Lis de Souza e , Souza Elio Ferreira de
Published: September 2023

O presente artigo tem por objetivo refletir sobre ancestralidade e como, a partir desta, deriva-se a autoestima quando são criadas imagens positivas acerca da negritude, no romance Maréia, de Miriam Alves, publicado em 2019. Analisa, também, a Autodefinição e a Autoavaliação (Collins, 2019) de Maréia, personagem homônima. Por meio da obra, é possível exaltar nossos ancestrais negros. Para tanto, o estudo está apoiado nas teorias de Collins (2016, 2019), Mongim (2017), Maldonado-Torres (2018), Woodson (2021), Carneiro (2005), Oliveira (2009), Ribeiro (2020), dentre outros. Os estudos tendem ao entendimento de que Maréia está sempre buscando, em seus ancestrais, a força para criar seus caminhos. Portanto, ela subverte a lógica colonial que invisibilizou os saberes provenientes da diáspora negra.
Prostate cancer in an elderly patient with a history of comorbidities
Authors: Stryczyńska-Mirocha Adriana , Mirocha Martyna
Published: September 2023

Prostate cancer is the most common cancer in men in Poland. The choice of treatment method depends on many factors, including the stage of the disease, the patient's age, life expectancy, the presence of comorbidities and the general condition of the patient. Hormone therapy is one of the basic methods of prostate cancer treatment, both in adjuvant and palliative treatment. Castration-resistant prostate cancer is an incurable disease. However, the introduction of new hormonal drugs to therapy significantly extended the survival time of patients with relatively low harmfulness of therapy.
Apalutamide as a new option for postponing metastatic disease in hormone-resistant patients with biochemical recurrence in prostate cancer
Authors: Dąbek Bartosz
Published: September 2023

Treatment of non-metastatic castration-resistant prostate cancer is a radically new option for cancer patients. Novel anti-hormonal therapy not only improves metastasis free survival but overall survival times and positively impacts quality of life. This case shows how apalutamide lowered tPSA level and postponed metastatic disease.
Apalutamid for treatment of nonmetastatic castration-resistant prostste cancer – case study
Authors: Sikora-Kupis Bożena
Published: September 2023

A special form of prostate cancer is non-metastatic castration-resistant prostate cancer. Patients with this form have rising prostate-specific antigen and castrate testosterone levels, with no radiological findings of metastatic disease on computed tomography and bone scan. The phase III trials demonstrated apalutamide, darolutamide or enzalutamide to be associated with a significantly longer median metastasis-free survival. The featured description presents one case of man with non-metastatic castration- resistant prostate cancer who was treated with apalutamide.
Influence of brassinosteroids on sex allocation in walnut (Juglans regia L.) flowers
Authors: Engin Hakan , Gökbayrak Zeliha
Published: September 2023

The effect of foliar treatment with brassinosteroid (BR) on gender distribution in flowers of walnut (Juglans regia L. cv. Chandler) was investigated. Grafted walnut saplings (‘Chandler’) on the wild walnut (Juglans regia L.) rootstock were planted into 70-liter pots with a soil: peat: perlite medium and grown in pots between 2016–2020. BRs (24-epibrassinolide; EBR and 22(S), 23(S)-homobrassinolide; HBR) were applied at a concentration of 1 mg L–1 for four consecutive years at the time of flower differentiation. The experimental design was completely randomized with three replicates. The results show that BR applications could alter the sexual distribution of the walnut’s flower. BRs application significantly increased the number of total flowers and female flowers per tree. The number of female flowers was also increased by the season. The highest number of female flowers (20.9) was observed in the trees in 2020 and the application of 1 mg L–1 of HBR. It was determined that the annual growth of the plant and the increase in the number of females and total flowers were positively related. The effect of BRs indicated that the response was BR-type specific.
Goethes Schweizer Reisen - Band I: Tagebücher, Briefe, Bilder
Band II: 25 Wanderungen
Authors: Wyder Margrit , Naumann Barbara , Steiger Robert
Published: September 2023

Goethe war der wohl bekannteste und literarisch bedeutendste Schweiz-Reisende aller Zeiten. Band 1 dieser Ausgabe präsentiert Goethes Schweizer Reisen in ihrem genauen zeitlichen und topographischen Ablauf. Briefe, Tagebücher und Notizen werden hier ediert und kommentiert vorgelegt. So lassen sich Goethes Eindrücke und Erlebnisse anhand der Originaltexte mitverfolgen. Band 2 widmet sich der Praxis: Er bietet die Möglichkeit, Goethes Wege heute in Form von kürzeren und längeren Wanderungen nachzugehen. Mit den 25 genau recherchierten Routen kann man Goethes Wege wandernd nachvollziehen und die historische Dimension von Schweizer Landschaften und Städten erleben.
Beide Bände sind reich bebildert: der Textband mit Goethes Zeichnungen und zeitgenössischen Illustrationen, das Wanderbuch mit aktuellen Fotos und Kartenausschnitten.
Ein unverzichtbares Vademecum für Goethe-Liebhaber, Schweiz-Reisende und Wanderfreundinnen.

Einen passenden Schuber für die beiden Bände können Sie kostenlos per E-Mail bestellen unter goethe-schweiz@gmx.ch.
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Nipah (Nypa fruticans Wurmb.) dan Pembuatan Formulasi Basis Krim
Authors: Rezky Ahmad , Gama Sabanniah Indjar , Narsa Angga Cipta
Published: September 2023

Daun nipah (Nypa fruticans Wurmb.) merupakan tanaman palem yang tumbuh di daerah pasang surut yang dekat dengan tepi laut yang diduga memiliki kandungan metabolit sekunder sebagai antioksidan dan kaya akan vitamin A dan C. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak daun nipah dan mendapatkan formula terbaik dari basis krim dengan memvariasikan konsentrasi asam stearat dan TEA. Metode penelitian yang dilakukan yaitu skrining fitokimia, uji parameter spesifik dan non-spesifik ekstrak meliputi organoleptis, kadar air, pH, kadar abu, kadar abu tidak larut asam bobot jenis, uji aktivtias antioksidan ekstrak etanol daun nipah dengan metode DPPH, formulasi serta evaluasi basis krim yang meliputi organoleptis, pH, tipe emulsi, daya sebar, dan viskositas. Hasil yang didapatkan ekstrak etanol daun nipah mengandung metabolit sekunder berupa fenol, tanin, dan steroid. Hasil parameter spesifik dan non-spesifik ekstrak diperoleh semua nilai parameter telah memenuhi standar yang berlaku. Aktivitas antioksidan ekstrak etanol daun nipah didapatkan nilai IC50 sebesar 2.379 ppm yang menunjukkan aktivitas antioksidan sangat kuat. Hasil evaluasi formulasi basis krim didapatkan basis krim F1, F2, F3 memenuhi persyaratan evaluasi krim.
Bioaktivitas Ekstrak Etil Asetat Hasil Fermentasi Fungi Endofit Batang Bajakah (Uncaria nervosa Elmer.)
Authors: Khoirunnisa Khoirunnisa , Gama Novianty Indjar , Arifuddin M. , Rusli Rolan
Published: September 2023

Uncaria nervosa Elmer. atau biasa dikenal dengan Bajakah merupakan tanaman endemik Kalimantan yang dipercaya dapat mengobati kanker. Pemanfaatan mikroorganisme fungi endofit menjadi upaya dalam menjaga keberlangsungan tumbuhan yang memiliki kemampuan transfer genetik dari tanaman inangnya. Tujuan dari penenlitian ini adalah mengetahui jumlah rendemen, mendapatkan jenis metabolit sekunder yang terkandung dalam ekstrak etil asetat, dan mengetahui toksisitas isolat fungi endofit berdasarkan nilai LC50 terhadap larva Artemia salina. Metode yang digunakan adalah isolasi fungi endofit, ekstraksi fungi endofit, uji fitokimia dengan KLT dan pengujian sitotoksik dengan metode Brine Shrimp Lethality Test (BSLT) menggunakan hewan uji dari larva Artemia salina. Jumlah rendemen isolat G1A1 dan isolat G1A3 masing-masing sebesar 0,0084% dan 0,0078%. Hasil skrining fitokimia isolat G1A1 adalah tanin (Rf = 0,55) dan triterpenoid (Rf =0,6). Pada isolat G1A3 mengandung triterpenoid (Rf = 0,5) dan flavonoid (Rf = 0,9). Nilai LC50 isolat G1A1 sebesar 512,86 ppm dan pada isolat G1A3 sebesar 660,7 ppm yang berpotensi sebagai sitotoksik.
Pengaruh Pemberian Teh Kulit Buah Salak (Salacca zalacaa) Terhadap Kadar Glukosa Darah Mencit yang di Induksi Aloksan
Authors: Ribatul Novia Dwi , Prasetya Fajar , Badawi Satriani
Published: September 2023

Diabetes melitus merupakan suatu penyakit tidak menular dan menjadi salah satu penyebab utama kematian di dunia. Pengobatan diabetes melitus pada umumnya di tangani dengan pemberian obat-obatan antidiabetes serta pemberian insulin, namun dalam jangka waktu konsumsi yang panjang terdapat efek samping yang dihasilkaan dari pemberian obat tersebut dan juga biaya pengobatan yang semakin mahal, sehingga penderita diabetes menggunakan cara tradisional untuk menetralkan kadar glukosa darah dengan pemberian teh kulit buah salak. Kulit buah salak (Salacca zalacca) merupakan salah satu limbah yang terbukti secara ilmiah dapat menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui informasi awal potensi teh kulit buah salak dapat menurunkan kadar glukosa darah mencit diabetes dan mengetahui berapa dosis yang efektif dalam menurunkan kadar glukosa darah. Metode penelitian ini menggunakan mencit jantan putih, yang terdiri dari 3 kelompok masing-masing diberi teh kulit buah salak dengan dosis 70 mg/kgBB, 140 mg/kgBB dan 210 mg/kgBB. Digunakan aloksan sebagai penginduksi diabetes selama tiga hari secara intrapeitoneal. Pengukuran glukosa darah menggunakan glukometer (Easy Touch GCU). Hasil penelitian menunjukkan pemberian teh kulit salak dapat menurunkan kadar glukosa darah pada mencit diabetes dan dosis 210 mg/kgBB menunjukkan hasil terbaik dalam menurunkan glukosa darah yaitu sebesar 40,94%, Sehingga dapat dikatakan teh kulit buah salak (Salacca zalacca) memiliki aktivitas sebagai antidiabetes.
Uji Efektivitas Ekstrak Daun Cemba (Senegalia rugata) terhadap Penyembuhan Luka Sayat pada Kelinci (Oryctogalus cuniculus)
Authors: Rahmadina Dewi , Kartab Novita Eka Putri , Indriyanti Niken
Published: September 2023

Obat luka adalah sediaan farmasi yang membantu mempercepat proses penyembuhan luka. Obat luka seperti povidone iodine mengandung antiseptik untuk mencegah infeksi. Povidone iodine memiliki aktivitas bakterisidal, toksisitasnya rendah, dan harganya terjangkau. Akan tetapi pada beberapa kasus, povidone iodine dapat menimbukan alergi. Daun cemba (Senegalia rugata) adalah tanaman endemik yang secara empiris dimanfaatkan sebagai penyembuh luka terbuka. Penelitian ini bertujuan untuk mengetahui hasil rendemen dari ekstraksi daun cemba, kemampuan ekstrak daun cemba sebagai penyembuh luka sayat, konsentrasi ekstrak daun cemba yang dapat memberikan aktivitas paling baik sebagai penyembuh luka sayat. Pengujian ini menggunakan kelinci sebagai subjek yang akan diberikan perlakuan berupa kontrol uji ekstrak daun cemba dengan varian konsentrasi basis salep yaitu 5%, 10%, dan 15%, untuk kontrol pembanding digunakan kontrol negatif berupa basis, kontrol positif berupa salep betadine, dan kontrol normal. Berdasarkan penelitian yang telah dilakukan, didapatkan besar rendemen ekstrak daun cemba sebesar 31,82%. Hasil skrinning fitokimia yang dilakukan, diketahui ekstrak daun cemba mengandung metabolit sekunder berupa alkaloid, flavonoid, tanin, steroid, dan saponin. Hasil uji menunjukkan bahwa ekstrak daun cemba konsentrasi 5% dan kontrol positif  dapat menyembuhkan luka pada ± hari ke-10.
Uji Perbandingan Antioksidan dari Produk Teh Daun Kelor, Teh Bunga Rosella dan Teh Daun Melati dengan Metode Seduhan Suhu Konstan
Authors: Rahim Abdul , Febriani Yuyun , Azim Muhlisun , Nisaa Nur Rezky Khairun
Published: September 2023

Radikal bebas dikenal sebagai suatu atom yang tidak memiliki pasangan elektron dan tidak stabil serta hanya memiliki satu elektron. Radikal bebas akan cepat beraksi untuk mencari pasangan elektronnya. Daun melati kaya akan antioksidan polifenol. Selain tanaman melati, salah satu jenis tumbuhan yang diduga sebagai antioksidan adalah kelor (Moringa oleifera, Lamk). Tanaman kelor telah dikenal selama berabad-abad sebagai tanaman multiguna padat nutrisi dan berkhasiat obat. Daun kelor mengandung metabolit primer seperti protein, lemak, karbohidrat, berbagai mineral, vitamin dan asam amino. Bunga Rosella banyak mengadung senyawa metabolit sekunder antara lain polifenol dan falvonoid. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antioksidan tertinggi pada teh dari beberapa merk dagang teh (teh daun kelor, teh bunga rosella dan teh daun melati) menggunakan metode DPPH dengan standar penyeduhan teh sesuai dengan yang diatur dalam SNI 01-1902-1995 dengan tingkatan suhu yang konstan. Hasil uji kuantitatif menunjukkan bahwa nilai IC50 teh bunga Rosella 148 ppm (antioksidan sedang), nilai IC50 teh melati 80 ppm (antioksidan kuat) dan nilai IC50 teh daun kelor 88 ppm (antioksidan kuat).
Validasi dan Analisis Allopurinol dan Deksamethason pada Jamu Pegal Linu di Kabupaten Semarang dengan KLT dan Spektrofotometri UV-Vis
Authors: Minarsih Tri , Roni Abdul
Published: September 2023

Jamu masih banyak digunakan oleh masyarakat Indonesia untuk pengobatan. BPOM melarang penggunaan Bahan Kimia Obat di dalam sediaan jamu. Penelitian ini bertujuan untuk melakukan validasi metode serta analisis kandungan allopurinol dan deksamethason di dalam jamu pegal Linu yang beredar di Kabupaten Semarang. Metode yang digunakan adalah KLT untuk analisis kualitatif dan Spektrofotometri UV-Vis untuk analisis kuantitatif. Sampel yang digunakan terdiri dari 8 sampel jamu pegal linu dan asam urat yang beredar di Ungaran, yang tidak terdaftar pada BPOM. Fase Diam yang digunakan adalah Lempeng Silika Gel GF 254 Fase Gerak yang digunakan kloroform:etil asetat 1:4. Dari 8 sampel yang dianalisis terdapat 2 sampel yang mengandung Allopurinol, yaitu sampel E dan F yang mempunyai harga Rf sebesar 0,2 sama dengan harga Rf baku allopurinol yang digunakan dan tidak ada sampel yang mengandung deksametason. Kadar allopurinol pada sampel E sebesar 2,1% dan dalam sampel F sebesar 1,14%. Hasil validasi metode yang dilakukan diperoleh nilai RSD = 0,75%, perolehan kembali 98,2- 101,6 %, batas deteksi = 1,09 ppm dan batas kuantifikasi = 3,66 ppm. Terdapat 2 sampel jamu yang mengandung allopurinol dengan kadar 2,17% dan 1,14%. Metode spektrofotometri UV-Vis yang digunakan memenuhi persyaratan validasi.
CIE Research Strategy 2023
Authors: Veitch Jennifer
Published: September 2023

The International Commission on Illumination (CIE) is a global non-profit organization dedicated to advancing knowledge and providing standardization to improve the lighted environment. Light and darkness form the fundamental rhythm of daily life for the planet and light reveals the details of the world around us. The CIE seeks to make possible the equitable and responsible provision of the proper light, in the proper place, at the proper time. Doing so is a critical element in humanity’s response to global environmental crises including climate change. Over 1 000 volunteer experts contribute to CIE committees to develop consensus on scientific fundamentals and application guidance that is published in the form of technical notes, technical reports and international standards. Continuing advances in scientific knowledge provide the foundation for new and revised CIE publications. The CIE Research Strategy identifies the topics that researchers should study now, so that the knowledge is available to support and guide the next generation of CIE reports and standards. First published in 2015, the CIE Research Strategy received minor updates in 2019 and 2020. The 2023 edition is a major revision and reflects the CIE’s aim to contribute to the achievement of the United Nations 2030 Sustainable Development Goals (SDGs).
Mirada al enfoque pedagógico y calidad de educación superior colombiana. Un estudio en la Universidad Surcolombiana
Authors: Castañeda Mogollón Rodrigo
Published: September 2023

En el año 2020¹ se inicia la ejecución de un proyecto de investigación titulado “Incidencia del Modelo Pedagógico en la Calidad de la Educación Superior en Colombia” en un grupo de profesores investigadores de algunas universidades del país. El grupo Red de Investigadores en Pedagogía y Didáctica del Lenguaje y Literatura de la Universidad del Tolima participó en dicho estudio en convenio con la Universidad Santo Tomás, liderados por el Maestro Luis Alfonso Ramírez Peña. En Bogotá las universidades involucradas fueron la Universidad Santo Tomás, Pedagógica Nacional, Juan N. Corpas y San Buenaventura; en Ibagué, en las universidades de Ibagué y del Tolima; y en Neiva, la Universidad Surcolombiana. En este informe de la fase final de la investigación, entre los interrogantes abordados, en síntesis, se encuentra la pregunta ¿Cuál es el estado de la calidad de la educación superior en Colombia que le permita responder adecuadamente a las necesidades de las culturas y organizaciones sociales, profundamente cambiantes e inciertas, del siglo XXI? Se encontró en la Universidad Surcolombiana, como en otras universidades abordadas, que los requerimientos del Consejo Nacional de Acreditación en Colombia (CNA) se reducen a los paradigmas del pasado, donde el maestro es el poseedor de los conocimientos y el estudiante asume su transferencia y tránsito en los procesos de aprendizaje.
Sacralidad y tabú: abordando la menstruación desde una clase de química
Authors: Gómez Fierro Wilmer A.
Published: September 2023

El propósito de la investigación es diseñar una propuesta pedagógica con el fin de reconocer la problemática de discriminación que padecen las mujeres frente al hecho de la menstruación y el uso de toallas higiénicas, abordado desde la clase de química. Para ello se desarrolló una propuesta pedagógica que radicó en la recolección de concepciones de los estudiantes respecto a preguntas de las problemáticas que padecen mujeres vulnerables y el diseño de una experiencia de aula de química, en específico sobre separación de mezclas, en donde, hicieron uso de las toallas higiénicas. De este modo, se generó una contribución para consolidar nuevas propuestas de trabajo pedagógico que permita una clase de química critica que contribuya a la lucha antidiscriminatoria.
Correlation of total phenolic and flavonoid contents on the antioxidant activity of Psychotria gitingensis and Psychotria pilosella
Authors: Aureada Mikaela Yakira M. , Duran Jo Dexter R. , Falcatan Stephanie Rafaelle A. , Pornillos Kirsten Marla T. , Villanueva Mary Angela G. , Ordas Jorge Anton D. , Tan Mario A.
Published: September 2023

The genus Psychotria (Rubiaceae) possesses various biological properties, ranging from phytochemical and pharmacological properties of their chemical constituents to traditional medical applications. Most Psychotria species remain unstudied despite high diversity and endemism in the Philippines. Hence, this study investigates the total phenolic and flavonoid contents of Psychotria gitingensis and Psychotria pilosella methanolic crude extracts, evaluates their antioxidant properties, and assesses their antibacterial properties. Results revealed that P. gitingensis fruit extract exhibited the highest phenolic content (254.45 ± 6.63 mg GAE/g extract) and flavonoid content (9.85 ± 0.49 mg QE/g). In addition, it also displayed the highest antioxidant activity (0.993 ± 0.041 mg/mg) in the ABTS assay. P. pilosella leaf extract exhibited the highest antioxidant activity in DPPH (70.53% ± 1.50), and P. gitingensis leaf extract showed the highest iron-reducing antioxidant power (86.06% ± 0.73) in FRAP. Paper disk diffusion tests, however, did not exhibit activity against selected nosocomial pathogens. The results of this study contribute to expanding the field of knowledge on alternative treatments and paving the way for the development of new medicinal products.
Integrating genetic markers and adiabatic quantum machine learning to improve disease resistance-based marker assisted plant selection
Authors: Albert Enow Takang Achuo , Bille Ngalle Hermine , Martin Bell Joseph , Leonard Ngonkeu Mangaptche Eddy
Published: September 2023

The goal of this research was to create a more accurate and efficient method for selecting plants with disease resistance using a combination of genetic markers and advanced machine learning algorithms. A multi-disciplinary approach incorporating genomic data, machine learning algorithms and high-performance computing was employed. First, genetic markers highly associated with disease resistance were identified using next-generation sequencing data and statistical analysis. Then, an adiabatic quantum machine learning algorithm was developed to integrate these markers into a single predictor of disease susceptibility. The results demonstrate that the integrative use of genetic markers and adiabatic quantum machine learning significantly improved the accuracy and efficiency of disease resistance-based marker-assisted plant selection. By leveraging the power of adiabatic quantum computing and genetic markers, more effective and efficient strategies for disease resistance-based marker-assisted plant selection can be developed.
Análisis psicométrico de la Escala de Cinismo Organizacional en trabajadores de la ciudad de Arequipa, Perú
Authors: Arias Gallegos Walter L. , Velásquez Ramos Diego , Galdos Jiménez Andrea , Huertas Solis Valeria G. , Salas Palomino Katiuska Y. , Olivares Villanueva Scarlet M.
Published: September 2023

En esta investigación se analizan las propiedades psicométricas de la Escala de Cinismo Organizacional (Salessi & Omar, 2014b) en una muestra de 710 trabajadores (58.59% hombres y 41.40% mujeres) de la ciudad de Arequipa, en Perú. Se trató de un estudio instrumental para cuyo procesamiento estadístico se analizó la estructura interna mediante el análisis factorial confirmatorio y para estimar la confiabilidad se aplicó la prueba Alfa de Cronbach y la prueba Omega de McDonald. Los resultados confirmaron la estructura de tres factores con óptimos índices de bondad de ajuste y de confiabilidad: Ideas Cínicas (ω= .886, α= .883), Conductas Cínicas (ω= .841, α= .841) y Emociones Cínicas (ω= .907, α= .906). Por tanto, se recomienda su uso en el ámbito organizacional local.
Deep learning for COVID-19 by X-ray images Analysis and Designing Diagnostic Application
Authors: Khaleel Thamer , Kalakech Ali
Published: September 2023

Nearly every element of life is being significantly impacted by the COVID-19 pandemic. Since COVID-19 was just recently identified, there isn't much known about the illness, how to identify it, or how to treat it. This has increased interest in the creation of AI-based automated detection systems, and deep learning is a group of machine learning algorithms used in AI that aim to automatically extract key properties from a dataset. Based on their architecture and learning principles, these neural networks are classified into a number of groups. Artificial neural networks (ANN), recurrent neural networks (RNN), and convolutional neural networks (CNN) are a few of the popular deep learning categories. Deep learning is therefore a powerful tool that could be used to classify data in ways that humans might not be able to. This makes it possible for computers to learn from modest quantities of data and provide excellent outcomes. For the first task in this investigation, multiple Convolutional neural networks (CNN) models were used.To maximize accuracy during training with maintain constant conditions. After training on x-ray images, VGG16, VGG19, and ResNet50V2, were found to ResNet50V2 have the highest accuracy (96%) and can be used in future chest x-ray studies and applications. Second, we designed a COVID-19 Diagnostic application. This app uses a chest x-ray to determine if a person has the disease or is healthy, saving medical staff time and energy and helping with preventative isolation. Test huge numbers from images in record time.
n-absorbing I-primary ideals in commutative rings
Authors: Anjuman Sarbast A. , Akray Ismael
Published: September 2023

We define a new generalization of n-absorbing ideals in commutative rings called n-absorbing I-primary ideals. We investigate some characterizations and properties of such new generalization. If P is an n-absorbing I-primary ideal of R and √IP=I√P, then √P is a n-absorbing I-primary ideal of R. And if √P is an (n-1)-absorbing ideal of R such that √(I√P) ⊆IP, then P is an n-absorbing I-primary ideal of R.
Ecological consciousness and behavior of modern students: a sociological analysis
Authors: Valeeva Marina Vladimirovna
Published: September 2023

The current environmental situation requires serious attention and active participation of every person. A special role in this process is played by the student youth – an active and promising part of society, capable of making a significant contribution to the development of ecological culture and changing environmental behavior. The ecological consciousness and behavior of students are becoming the object of more and more in-depth study by specialists in various fields of knowledge, including sociologists. To assess the level of formation of ecological consciousness and behavior in 2023, a sociological study was conducted using two methods: a questionnaire, the object of which was the student youth of Yekaterinburg and an expert interview. The study revealed the attitude of young people to the environment, as this is an indicator of the formation of ecological consciousness. Next, the key environmental problems that, according to the youth, are most acute were considered, as well as real practices that students implement while taking care of the environment were considered. In addition, the research revealed the role of the university as an actor influencing the formation of environmental consciousness and behavior. As a result, it was concluded that modern youth in general show interest and awareness in relation to environmental problems, but in reality their environmental behavior is often uneven and limited.
Doğrudan Yabancı Yatırım Çıkışları ile Ekonomik Kırılganlık Arasında Nedensellik: Sekiz Kırılgan Ekonomi Üzerine İnceleme
Authors: EMEÇ Abdulkadir Sezai , KOLUMAN Ahmet
Published: September 2023

Bu çalışmanın amacı, kırılgan sekiz ekonominin (Arjantin, Brezilya, Çin, Kolombiya, Hindistan, Güney Afrika, Tayland, Türkiye) doğrudan yabancı yatırım çıkışları ile ekonomik kırılganlık göstergeleri arasındaki nedensellik ilişkisini araştırmaktır. 1995-2021 dönemini kapsayan çalışmanın veri seti, doğrudan yabancı yatırım çıkışları ile ekonomik kırılganlık göstergesi olarak belirlenen; tüketici fiyat endeksi, merkezi hükümet borçları/gayrisafi yurt içi hâsıla, toplam rezerv/dış borç, M2/gayrisafi yurt içi hâsıla, cari işlemler dengesi/ gayrisafi yurt içi hâsıla, bankalar tarafından sağlanan yurtiçi özel sektör kredileri/ gayrisafi yurt içi hâsıla ve toplam borç/ihracat değişkenlerinden oluşmaktadır. Kónya (2006) tarafından geliştirilen bootstrap panel nedensellik analizi sonuçlarına göre; ekonomik kırılganlığı temsil eden değişkenler ile doğrudan yabancı yatırım çıkışları arasında nedensellik ilişkisi en çok Tayland’da, en az Çin’de görülmektedir. Araştırma sonuçları, ekonomik kırılganlık göstergeleri ile doğrudan yabancı yatırım çıkışları arasındaki nedensel ilişkinin yönü konusunda güçlü bir fikir birliği olmadığını göstermektedir. Çalışmanın bulgularına dayanarak her ülkenin kendi iç dinamiklerine uygun politika geliştirmesi önerilmektedir.
Relajación residual en la unidad de cuidado postanestésico. Un estudio descriptivo de corte transversal
Authors: Tejada Jorman H. , Tovar Jesús H. , Benavides Diana C. , Beleño Carlos , Gutiérrez Valentina
Published: September 2023

Introducción: La relajación residual posoperatoria se asocia a complicaciones mayores respiratorias. El uso de bloqueantes neuromusculares requiere de monitoria neuromuscular que brinde mayor seguridad al paciente. Objetivo: Determinar la prevalencia de relajación residual y los factores relacionados con su presentación. Metodología: Estudio descriptivo, transversal, en pacientes posquirúrgicos con anestesia general y relajación neuromuscular, llevados a la unidad de cuidados postanestésicos del Hospital Universitario Hernando Moncaleano Perdomo. Se registró la respuesta del abductor del pollicis a un estímulo de tren de cuatro con aceleromiografía (TOF WATCH SX- marca Organon, modelo 57-20100699), en los primeros 10 minutos de llegar a sala de recuperación y la temperatura del paciente. Relajación residual postoperatoria definida como un Tren de cuatro < 90%. Se realiza análisis uni y bivariado de las variables para determinar complicaciones y posibles asociaciones. Resultados: N = 185 pacientes, mediana de edad 42 años (RIQ 28-62), género femenino (55,7%). Más del 50% fue ASA I y II, siendo el abordaje abierto (58,4%) el más empleado. La prevalencia de relajación residual del 43,2%; con predominio de mujeres (67,7%) y alta proporción de abordaje quirúrgico endoscópico (53,8%). Dentro de los factores asociados a la presencia de relajación residual, tener cirugía abierta resultó factor protector [OR 0,45 (IC95% 0,24-0,86)] y pertenecer al género femenino [OR 2,09 (IC 95% 1,12-3,89)] un factor de riesgo para su presentación. Conclusión: En un grupo de pacientes sometidos a anestesia general con relajación neuromuscular, se identificó prevalencia de relajación residual en cerca de uno de cada dos pacientes, identificando que pertenecer al género femenino duplica el riesgo de presentación de relajación residual y tener cirugía abierta resulta como factor protector.