bluuebunny/crossref_metadata_2025 huggingface dataset:
The rules on foreigners’ right to acquire ownership of agricultural land in Slovenian, Croatian and Serbian law
Authors: Dudás Attila
Published: January 2023

The paper gives an overview of the rules on the acquisition of ownership of agricultural land by foreigners in Slovenia, Croatia and Serbia. Slovenia and Croatia initiated their accession to the European Union at different times and under different conditions, while Serbia is not yet a member state of the Union, but has been a candidate country for several years, and the harmonization of its national law with the acquis communautaire has been under way for some time. These circumstances determine the right of foreigners, in particular natural persons and legal entities from the European Union, to acquire ownership of agricultural land in these countries. In Slovenia non-EU natural persons and legal entities cannot acquire ownership of agricultural land. In contrast, Slovenia opened its real estate market rather early to EU citizens and legal entities. Only the Association Agreement provided for a transitional period of four years during which they could not acquire ownership of agricultural land. From 2003 onwards, citizens and legal entities from the EU are entitled to acquire land ownership without restriction. The Accession Treaty prescribed no moratorium. Similarly to Slovenia, non-EU natural persons and legal entities may not acquire ownership of agricultural land in Croatia either. The Accession Treaty provided for a seven-year moratorium on the acquisition of ownership of agricultural land by EU citizens and legal entities. The primary moratorium expired on 30 June 2020. However, the EU Commission approved an extension of the moratorium for another three years. Thus, EU citizens and legal entities are still unable to acquire ownership of agricultural land until 30 June 2023. Foreigners’ right to acquire ownership of agricultural land is in general excluded in Serbian law as well. The Stabilization and Association Agreement from 2008 provided for the liberalization of the real estate and land markets for EU citizens and legal entities. However, in 2017 the Serbian legislature amended the Act on Agricultural Land only few days before the expiry of the moratorium on ownership included in the Stabilization and Association Agreement. Nominally, the amendments were intended to introduce explicit regulation on the right of EU citizens and legal entities to acquire ownership of agricultural land, as required by the Stabilization and Association Agreement. However, instead of extending the same conditions applicable to the domestic natural persons and legal entities to those from the EU, the legislator specified additional set of conditions applicable only to the latter. It, in fact, excludes legal entities from the right to acquire property, as they cannot be registered family farmers, and makes the right of natural persons subject to conditions that effectively exclude their acquisition of ownership by 1 September 2027 due to the calculation of deadlines.
Legal Responses to the Challenges Facing the Young Agricultural Generation
Authors: Hegyes Péter
Published: January 2023

This paper introduces the legal responses to the challenges facing the young agricultural generation. The young generation of farmers is facing several challenges that make production difficult. Farmers will only be able to farm successfully in the face of such challenges if a supportive and enabling legislative environment is in place.
Implementation of the Village Financial System (Siskeudes) to Improve Village Financial Management Accountability
Authors: Fauziah Nurul , Hermawan Sigit
Published: January 2023

This study aims to implement the Village Financial System (Siskeudes) to Increase Accountability of Village Financial Management (Study in Connectrejo Village Kec. Sukodono Kab. Sidoarjo). The approach used in this study is a qualitative approach as a method that will provide an overview of the Implementation of the Village Financial System (Siskeudes) to Increase Accountability of Village Financial Management. This research was conducted in the village of Tutuprejo sub-district Sukodono Kab. Sidoarjo. Connectrejo Village is one of the villages in Sidoarjo Regency that has implemented the Village Financial System application since 2016. In this study, there were several informants including the Village Head, Village Treasurer and Village Secretary in the Tutuprejo village in Sukodono District, besides that the researchers also involved other parties who outside the village of Tutuprejo, Sukodono Sub-district, namely the Accounting Lecturer of FBHIS UMSIDA who takes the Village, District, and BUMDes Accounting courses due to strengthen the results of interviews that have been carried out by researchers. The results of this study indicate that the process of using the Village Financial System (Siskeudes) application in Connectrejo Village has been running well. The stages of managing the village financial system starting from the process of inputting planning documents, budgeting, administration, accountability and reporting have been well structured in accordance with Permendagri No. 20 of 2018. The quality of village financial accountability in Connectrejo Village after using the Siskeudes application has brought good changes, including making it easier for the Connectrejo Village Government in the process of reporting village financial accountability, producing accountable financial reports and in accordance with applicable rules and regulations.
Analysis of the Village Financial Information System on Village Fund Management Accountability
Authors: Rahayu Ervina , Rahmawati Imelda Dian
Published: January 2023

The existence of a regional autonomy policy makes the Village Government faced with demands to be independent in managing the resources and potentials that exist in the Village, but this is also a gap for fraud in village financial management. Then the existence of the Village Financial System application launched by the Central Government is expected to be able to realize accountability for financial reports in the Village, so that the problem raised by the researcher is the application of the Village Financial System to the accountability of village fund management. The research method used is a qualitative method with an interpretive approach where data collection is in the form of primary data, namely by participatory observation and open interviews and secondary data sources through documents related to research. The results of the study show that the existence of the Siskeudes application facilitates the performance of village officials in managing village finances, although its application does not fully refer to Permendagri No. 20 of 2018. However, accountability in managing village funds can be realized and is one tool to minimize fraud.
Child-Parent Communication to Form Islamic Character
Authors: Najikhah Afiah , Romadlon Dzulfikar Akbar
Published: January 2023

Communication is very important for human life. In addition to interacting, communication is also used as a medium in delivering information and a tool to persuade others. Communication is usually done and starts from the smallest scope, namely the family. Through communication, parents in the family can influence other members, especially children. Communication that is carried out continuously by parents to children can also form habits that are spontaneously carried out by children so that they can create qualitative research with data collection techniques in the form of interviews, observations, and documentation and the formation of characters according to the wishes of parents. how to communicate between parents and children so as to create a behavior that forms a character in the future. The purpose of this study is to determine the form of parent-child communication, how parents shape the child's Islamic character, and the success of parent-child communication. This research was conducted in Randubango Village, Mojosari District. In this study, the author uses a phenomenological approach. This study involved ten parents and ten children as informants. The researcher also asked several questions which included how communication occurs between parents and children, how parents build Islamic character towards their children, and how successful parent-child communication is in building Islamic character in Randubango Village, Mojosari District. The results of the study show that: First, The form of parent-child communication is done through conversation, intimate interaction, and evaluation. Second, the method of forming the Islamic character of children in Randubango Village, Mojosari District is carried out through conversation, reading stories of inspirational figures, exemplary from both parents and habituation. Third, for the success of parent-child communication, namely with an open attitude, and mutual trust.
The Phenomenon of Murals and Graffiti as Media for Social Criticism in the Perspective of Social Interaction Alfred Schutz
Authors: Setiawan Dwi , Utomo Djarot Meidi Budi
Published: January 2023

The phenomenon of murals and graffiti has existed since time immemorial, the development is very massive in several cities in Indonesia, including the city in Sidoarjo, in Sidoarjo itself there are several points that are being targeted by artists as a form of social criticism media that occurs in the city of Sidoarjo, then from that to find out what motives behind them in drawing about social criticism in the city of Sidoarjo in carrying out social criticism. Sidoarjo. This study uses qualitative research with phenomenological methods, the theory used is Alfred Schutz. This data collection technique uses participant observation, in-depth interviews. and documentation. The results of this study indicate that the motives of these artists depart from their anxiety that they experience in their daily lives. So it's not surprising that they drew on social criticism in Sidoarjo. This also shows that these artists have limitations in the medium of expression in their work in the Public Space Room in Sidoarjo.
KOMPAKS Community Communication Network in Cat Care
Authors: Alam Bahrul , Rochmania Ainur
Published: January 2023

The study aims to describe the KOMPAKS community communication network in cat care. The method used in this study is quantitative descriptive with communication network analysis techniques. The population of this study is the KOMPAKS Community. Snowball Sampling technique for sampling while data retrieval using questionnaires and interviews is not structured. Data analysis techniques use communication network techniques with the help of the UCINET 6 application. The result of this study is, the first pattern of communication network structure formed in the Kompaks community is the structure of the Roda communication network. Both roles of communication network structure in the KOMPAKS Community found roles, neglected. Third, in this study, there are no clicks because the terms and conditions on the click do not have a KOMPAKS Community communication network in cat care. The four leaders of the opinion that there are 6 people in the network have an important role in influencing and increasing the participation of community members in cat care. Fifth in this study there are 4 types of innovation adopters in research, namely, innovator, early adopter, early majority, late majority.
Management of Island Tourism Destinations in Sidoarjo Regency
Authors: Suryani Elisa Indah , Mursyidah Lailul
Published: January 2023

Lusi Island is one of the tourist destinations in Sidoarjo which is expected to become an environmentally friendly tourist destination with the theme of utilization, research, and conservation of mangroves. Lusi Island is not widely known by the public because visitors are still dominated by the Jabon sub-district and the surrounding area. This study aims to analyze and describe the management and constraints in the Management of Tourism Destinations on Lusi Island in Sidoarjo Regency. The research method used is a qualitative approach, data collected through observation, interviews and documentation, while the data sources are primary and secondary data. Informants who were determined by interview, the informants were UPT BPSPL Wilker staff, East Java Directorate General of PRL, Lusi Island Guard and Head of the Sidoarjo Regency Tourism Office, data analysis derived from Miles and Huberman data, namely through data collection, data, data presentation and conclusions. The results of this study indicate that the process of managing Lusi Island has not been maximized because there are several inhibiting factors. As for some of these factors, there is no government intervention in the process of maintaining and developing the island and there is no legality on the island of Lusi in Sidoarjo Regency.
Transformational Leadership, Workload, and Entrepreneurial Motivation in Increasing Organizational Commitment
Authors: Maufuzah Intan Anis , Abadiyah Rifdah
Published: January 2023

The purposed of the following study are to analyze and describe the impact of transformational leadership variables, workload, and entrepreneurial motivation on organizational commitment in IKM tas UD. Suwarlandono Tanggulangin. In this study, using quantitative research methods, data collection was distributed through a questionnaire/questionnaire, with a sample using a saturated sample, where there were 170 respondents in IKM bag UD. Suwarlandono Tanggulangin. The data analysis used multiple linear regression test, asumsi classic test, , and also hypothesis testing, namely partial and simultaneous tests, and data management using SPSS version 22 software. Primary data collection was carried out by distributing questionnaires which were measured using an interval scale, the testing used Validity and Reliability Test. This study proves that transformational leadership, workload, and entrepreneurial motivation have a partial or simultaneous influence on organizational commitment.
The Influence of Leadership, Work Environment, and Discipline on Work Performance
Authors: Agustini Elly , Sari Herlinda Maya Kumala
Published: January 2023

This study aims to determine the effect of leadership, work environment and discipline on employee performance (Case Study: Bmt Madani in Taman, Sidoarjo – East Java). The method used in this research is a quantitative approach. Sampling in this study was carried out by saturated sampling method, with the number of respondents as many as 55 respondents from BMT Madani employees. The data analysis technique used in this study used the SPSS version 24 program. The results of this study prove that Leadership has a positive and significant effect on the performance of BMT Madani employees, the Work Environment has a positive and significant effect on the performance of BMT Madani employees, Discipline has a positive and significant effect on the performance of BMT Madani employees. Leadership Work Environment and Discipline have a simultaneous effect on Employee Performance at BMT Madani (Case Study: BMT Madani in Taman, Sidoarjo – East Java).
The Effect of Knowledge, Leadership Style and Work Stress on Employee Performance with Innovation as an Intervening Variable
Authors: Kebajikan Satriyo Gadang , Sumartik Sumartik
Published: January 2023

The purpose of this study was to determine the effect of knowledge, work stress and leadership style on employee performance at UMKM Sumber Rejeki Tanggulangin with innovation as an intervening variable. The type of research is survey research with a quantitative approach. Because the total population is less than 100 or can be said to be a saturated sample, the total sample used is the same as the total population, namely 45 respondents. The data analysis technique used is path analysis. The data collection technique used in this research is to distribute questionnaires and the tool to analyze the data obtained is to use IBM SPSS Statistics 25 for windows. The results obtained from this study prove that 1) Knowledge variable affects innovation at UMKM Sumber Rejeki Tanggulangin 2) Job stress variable affects innovation at UMKM Sumber Rejeki Tanggulangin 3) Leadership Style variable affects Innovation at UMKM Sumber Rejeki Tanggulangin 4) Knowledge variable Affects Employee Performance at UMKM Sumber Rejeki Tanggulangin 5) Work stress variable affects employee performance at UMKM Sumber Rejeki Tanggulangin 6) Variables of Leadership Style affect employee performance at UMKM Sumber Rejeki Tanggulangin 7) Innovation variable affects employee performance at UMKM Sumber Rejeki Tanggulangin 8) Knowledge variable affects employee performance through innovation at UMKM Sumber Rejeki Tanggulangin 9) Variable work stress affects employee performance through innovation at UMKM Sumber Rejeki Tanggulangin 10) Variable leadership style does not will have an effect on employee performance through innovation at UMKM Sumber Rejeki Tanggulangin.
The Influence of Leadership, Supervision and Work Motivation on Employee Work Effectiveness with Work Discipline as Intervening Variable
Authors: Fawaid Muhammad , Ubaidillah Hasan
Published: January 2023

The purpose of this study was to determine and analyze the influence of leadership, supervision and work motivation on work effectiveness with work discipline as an intervening variable at UD. Ridzil Jaya Utama. The research uses a quantitative approach. The sample in this study were all UD employees. Ridzil Jaya Utama with a total of 60 people. Collecting data in this study in the form of a questionnaire. The data analysis technique was carried out using path analysis using partial hypothesis testing, simultaneous testing, multiple correlation coefficient tests and multiple determination coefficients. The results showed that: 1) Leadership had an effect on work effectiveness, 2) Leadership had an effect on work effectiveness with work discipline as an intervening variable, 3) Supervision had an effect on work effectiveness with work discipline as an intervening variable, 4) Supervision had an effect on work effectiveness with discipline. work as an intervening variable, 5) work motivation affects work effectiveness, 6) motivation affects work effectiveness with work discipline as an intervening variable, and 7) work discipline affects work effectiveness.
The Influence of Transformasional Leadership Style and Organizational Culture on Employee Performance with Motivation as an Intervening Variabel
Authors: Maulana Mochamad Luthfi , Oetarjo Mas
Published: January 2023

This study aims to determine the effect of transformational leadership style and organizational culture on employee performance with motivation as an intervening variable in UKM Sumber Lancar Keramik. This research uses quantitative research with hypothesis testing. The sample used in this study were 50 employees at UKM Sumber Lancar Keramic. The analytical tool used in this research is path analysis technique with the help of SmartPLS (Partial Least Square) software version 3.0 for windows. The primary data in this study were obtained from a questionnaire whose measurement was using a Likert scale which was tested for validity and reliability. The results of this study prove that (1) transformational leadership style is positively and significantly related to motivation, (2) organizational culture is positively and significantly related to motivation, (3) transformational leadership style has positive and insignificant effect on employee performance, (4) organizational culture positive and insignificant effect on employee performance, (5) motivation is positively and significantly related to employee performance, (6) leadership style is positively and significantly related to employee performance with motivation as an intervening variable, (7) organizational culture is positively and significantly related to performance employees with motivation as an intervening variable.
Los Aromas y los perfumes en al-Andalus: Sus usos y contenedores
Authors: Girona Calvé Alicia
Published: January 2023

En el presente artículo se pone en valor la importancia de la sensibilidad olfativa en la cultura andalusí a partir de la consecuente configuración de obras artísticas, ya sean éstas objetos suntuarios vinculados a las sustancias aromáticas o plasmaciones artísticas de estos mismos objetos. Para ello, hay que prestar atención a las materias odoríferas más preciadas, teniendo en cuenta su procedencia y el largo periplo comercial que sufrían hasta llegar a la península ibérica. Es necesario, a su vez, comprobar cuáles eran los usos de los aromas y en qué contextos eran utilizados. Finalmente, se atiende a las piezas en sí, presentando diversos ejemplares de pebeteros e incensarios, esencieros y píxides, así como también se analizan algunas representaciones de redomas contenedoras de perfumes.
La imagen de Andalucía y Sevilla en Charlie Chaplin’s Burlesque on Carmen (Charles Chaplin, 1916)
Authors: Pérez García Lucía
Published: January 2023

Desde 1915 hasta la actualidad, muchos directores nos han dejado su visión de Carmen. Una visión que en muchas ocasiones ha estado condicionada por la de los viajeros y artistas del siglo XIX. Es el caso, sobre todo, de los primeros filmes, tanto por su cercanía temporal con el movimiento romántico, como por encontrarse en un momento de desarrollo de la técnica cinematográfica, donde los medios no permitían grandes alardes, y primaba el espectáculo. Ejemplo de ello es la Carmen de Chaplin la cual, además, tiene la peculiaridad de tratarse de una parodia. El interés que genera conocer la visión de tan importante director se ve, pues, duplicado, ya que una parodia no hace más que ahondar en el tópico hasta la exageración. Así, en este trabajo hago un análisis cinematográfico de la imagen de Andalucía y Sevilla que se desprende de esta producción, buscando entender su visión personal y relación con nuestra cultura, y cómo esta fue recibida.
La producción religiosa del escultor malagueño Salvador Gutiérrez de León (1777-1838) en la provincia de Cádiz y la ciudad de Ceuta
Authors: Flores Matute Francisco Jesús
Published: January 2023

Se exponen en este estudio una serie de esculturas y grupos escultóricos de carácter sacro localizados en la provincia de Cádiz y la ciudad de Ceuta que, por sus características formales, son adscribibles a la labor del escultor Salvador Gutiérrez de León, constituyendo una ampliación de su poco conocido catalogo. Asimismo, se analizan las características técnicas, estéticas y formales de dicho autor para mejor comprensión de su poética personal y su aplicación en el corpus artístico del susodicho.
La repristinación artística de la antigua iglesia conventual de los capuchinos de Málaga en el siglo XVIII
Authors: Ramírez González Sergio , Rodríguez Morgado Iluminada
Published: January 2023

El presente trabajo aborda el estudio de las reformas artísticas acometidas durante el siglo XVIII en el templo del antiguo y popular convento de los capuchinos de Málaga. En estas desempeñó un papel capital como mentor de temas, leyendas e iconografías el célebre predicador de la orden fray Diego José de Cádiz, quien demostró siempre una enorme sensibilidad hacia este tipo de iniciativas. Recientes restauraciones del interior de la iglesia permiten analizar parte de su primitiva decoración epidérmica, en especial las pinturas murales y las de caballete adscritas a algunos de los retablos. Asimismo, se corrigen errores interpretativos y de identificación de los personajes representados, que venían arrastrándose desde tiempo atrás.
Strength and toughness inputs to fitness for service analysis of existing hydraulic steel structures
Authors: Schultz Martin , Milligan Jarrod , Skahill Brain , Campbell Leslie , Sauser Phillip , Bell Ramsay
Published: January 2023

The purpose of this effort is to describe a database containing information about the strength and toughness of steel used in existing hydraulic steel structures (HSS). The lack of information about these properties often presents a barrier to conducting fitness for service (FFS) analysis. The statistical dependence between strength and toughness variables and other database fields is evaluated to assess their potential as predictive variables.
Artificial Intelligence: Transforming Ayurveda
Authors:   Professor, Department of Kayachikitsa, GS Ayurveda Medical College and Hospital, Pilkhuwa, Hapur, Uttar Pradesh 245304, India., Singhal Ankur , Gupta Komal ,   Assistant Professor, Department of Swasthwritt, GS Ayurveda Medical College and Hospital, Pilkhuwa, Hapur, Uttar Pradesh 245304, India.
Published: January 2023

As we know technology is at its boom in 21st century and it has touched our every aspect of life including The Ayurveda: ‘The science of life’. So for upgrading this ancient and 5000 yrs old system of medicine there must be full fledged inclusion of technology that allows computers and machines to function in an intelligent manner. This change with the help of technology is called as Artificial intelligence. It is the simulation of human intelligence processes by machines, especially computer systems. By adopting and adapting this digital world in the field of Ayurveda we can create a revolutionary change. The development of artificial intelligence (AI) in the medical field has been growing rapidly. The majority of the studies utilized AI models to predict certain patterns and find reliable computerized models to assist physicians. The objective of this article is to categorize and seek the current and further usage of AI in Ayurveda. A systematic scoping review has been conducted. The entire database, articles, and news have been used to find studies regarding AI and Ayurveda. A broad-range search strategy was applied to locate all relevant studies. Although the results from this review have shown the potential use of AI models in Ayurveda, future research ought to focus on verifying and validating the models by performing a large-scale clinical trial to better promote AI in Ayurveda in the era of digital health.
Out-of-pocket expenditures associated with congenital zika syndrome in Brazil: an analysis of household health spending
Authors: Pereira Claudia , Cavalcanti Luciano , Hofer Cristina , Reis Carla
Published: January 2023

Objective: The study aims to estimate catastrophic health expenditures associated with the diagnosis and follow-up treatment of Congenital Zika Syndrome (CZS) in children affected during the 2015-2016 epidemic in Brazil. Catastrophic health expenditures are defined as health spending that exceeds a predefined proportion of the household’s total expenditures, exposing family members to financial vulnerability. Methods: Ninety-six interviews were held in the cities of Fortaleza and Rio de Janeiro in a convenience sample, using a questionnaire on sociodemographic characteristics and private household expenditures associated with the syndrome, which also allowed estimating catastrophic expenditures resulting from care for CZS. Results: Most of the mothers interviewed in the study were brown, under 34 years of age, unemployed, and reported a monthly family income of two minimum wages or less. Spending on medicines accounted for 77.6% of the medical expenditures, while transportation and food were the main components of nonmedical expenditures, accounting for 79% of this total. The affected households were largely low-income and suffered catastrophic expenditures due to the disease. Considering the family income metric, in 41.7% of the households, expenses with the child’s disease exceeded 10% of the household income. Conclusion: Public policies should consider the financial and healthcare needs of these families to ensure adequate support for individuals affected by CZS.
Custos das internações de pacientes com trauma ortopédico em uma unidade hospitalar
Authors: Santos Luciene , Santos Ernandes , Fernandes Flávia , Xavier Saulo
Published: January 2023

Objetivo: Analisar os custos das internações de pacientes com traumas ortopédicos internados em um hospital de referência. Métodos: Estudo quantitativo analítico. A pesquisa teve amostra de 200 prontuários. Foram utilizados testes de Mann-Whitney e Kruskal-Wallis e correlação de Spearman para a comparação dos valores médios das Autorizações de Internação Hospitalar (AIHs) e as características sociodemográficas e clínicas; significância de 5% e confiança de 95%. Resultados: Em relação aos resultados obtidos do valor médio das AIHs, segundo as características sociodemográficas e clínica, o sexo de maior custo foi o feminino (1.673,2) (p = 0,0016), com lesão localizada no quadril (1.973,8) (p = 0,0002), na parte anatômica do fêmur (2.595,3) (p = 0,0001). Houve destaque para a prevalência de pacientes com possíveis sequelas (1.924,2) (p = 0,0185) e óbito (3.919,4) (p = 0,1015). Conclusão: No estudo, foi identificado que os maiores custos de internações foram relacionados a pacientes do sexo feminino, com lesões em fêmur, tendo como etiologia a queda; ademais, fraturas expostas e localizadas na região do quadril possuem custos elevados. Possíveis sequelas e óbitos também têm valores maiores em relação aos custos das AIHs.
Tectonic Factors Restricting Differences among Layers in Microstructure of Ultradeep Clastic Rock Reservoir: A Case Study on Cretaceous Bashijiqike Formation in Kuqa Depression
Authors: Su Miaomiao , Han Denglin , Zhang Ronghu , Zeng Qinglu , Lin Zhenzhen , Wang Chenchen
Published: January 2023

The Cretaceous Bashijiqike Formation in the Kelasu structural belt of Kuqa Depression is an ultradeep reservoir with burial depth of more than 6 km. Due to the influence of strong thrust nappe from the South Tianshan in the north, the burial depth gradually deepened from north to south in the Kelasu tectonic belt. With the increase of the burial depth, the influence of tectonic compression relatively weakens, and the formation mechanism that affects the microstructure of ultradeep clastic reservoir is changed. Comprehensive analysis of thin section and quantitative evaluation of minerals by scanning electron microscopy (QEMSCAN), scanning electron microscope (SEM), and micro-CT scanning are used to investigate the characteristics of the Cretaceous Bashijiqike Formation at the depth of 8000 m (TVD) in various stress sections. The result shows that, for the ultradeep reservoir with burial depth up to 8000 m, its reservoir characteristics and interlayer differences are not completely restricted by the neutral surface effect. (1) The porosity and permeability of various stress sections are different, and the reservoir physical properties of the tensile section are higher than that in the compressive section. (2) The pore types, pore radius, and pore throat connectivity of various stress sections are different, and the development of pores and throats in the tensile section is better than that in the compressive section. (3) As an ultradeep clastic rock reservoir, the vertical fracture development characteristics of Well Bozi9 at the depth of 8000 m differ from that in Kela-Keshen area at the depth of 6000 m in the model of strain neutral surface. The interlayer difference in the microstructure of ultradeep clastic rock reservoir is clarified, which has a positive effect to evaluate and predict the distribution of favorable deep reservoir.
Institutionalization of the Philippine Health Laboratory System (PHLS)
Authors: Balderama Hyacinth Joy , Tesoro Valerie Anne , Antonio Terence John , Ramones Richard Albert
Published: January 2023

In 1966, Section 3 of Republic Act (R.A.) 4688, entitled “An Act Regulating the Operation and Maintenance of Clinical Laboratories and Requiring the Registration of the Same with the Department of Health, Providing Penalty for the Violation Thereof, and for Other Purposes,” provided for the establishment of the Bureau of Research and Laboratories (BRL) under the Department of Health (DOH). The BRL served as the central laboratory that governed the operation of regional public health laboratories. The BRL’s function was delegated to different offices in 2000 by Executive Order 102 s. 1999 entitled “Redirecting the Functions and Operations of the Department of Health,” which was premised in part with Section 78 of the General Provisions of R.A. 8522 (“General Appropriations Act of 1998”) authorizing the President to direct changes in organization and key positions of any department, bureau, or agency.
Towards this direction, the function of the BRL was distributed to different agencies, and the Philippines designated six (6) national reference laboratories that catered to communicable and non-communicable diseases. Five (5) subnational reference laboratories for emerging and re-emerging infectious diseases were established in response to the 2009 Influenza AH1N1 pandemic. The DOH issued Administrative Order No 2012-0021 to establish a national and regional network of laboratories.
A Coordinate-based Fuzzy Encoding Strategy for Compressing Grayscale Images
Authors: Wang Dan , Zhu Xiu-bin , Pedrycz Witold , Yu Zhenhua , Li Zhiwu
Published: January 2023

Image compression techniques realized in various ways have become an indispensable part in the practical storage and transmission of digital images. In this study, we present a novel method of lossy compression based on sampling and fuzzy encoding for grayscale images and discuss the problem of their reconstruction. First, an image is divided into a number of non-overlapping blocks of pixels. Next, we perform multiple rounds of random sampling. In each round, a number of pixels are selected as prototypes for the representing the corresponding block. Each pixel in the block is reconstructed based on the gray-levels of the prototypes and membership degrees computed with respect to the distances of each pixel to the prototypes. The reconstruction abilities delivered by the prototypes are quantified by a certain objective fidelity criterion and the prototypes leading to lowest reconstruction error are determined as representatives of current block. Finally, once the representatives in each block have been determined, we reconstruct the whole image based on these prototypes. Experimental studies as well as visual evaluations show that the proposed algorithm is able to achieve high compression ratios while preserving the overall fidelity in the decompressed images.
High Dose Intravenous Anakinra Treatment is Safe and Effective in Severe and Critical COVID-19 Patients: A Propensity Score Matched Study in a Single Center
Authors: BEKTAS MURAT , Yüce Servet , Ay Mustafa , Uyar Muhammed Hamdi , Önder Mustafa Erkut , Kılıç Muhammed İkbal
Published: January 2023

Background: In COVID-19 severe disease course such as need of intensive care unit (ICU) as well as development of mortality is mainly due to cytokine storm. In this study, we aimed to evaluate the high dose intravenous anakinra treatment response and outcome in patients with severe and critically ill COVID-19 compared to standard of care.
Method : This retrospective observational study was carried out at a tertiary referral center. The study population consisted of two groups as follows; the patients receiving high dose intravenous anakinra (anakinra group) between 01.09.2021 and 01.02.2022 and the patients treated with standard of care (SoC, control group) as historical control group who were hospitalized between 01.07.2021 and 01.09.2021.
Results:After the propensity score 1:1 matching 79 patients in anakinra and 79 patients in SoC matched and included into the analysis. Mean±SD patient age was 67.4±16.7 and 67.1±16.3 years in anakinra and SoC group, respectively (p=0.9). Male gender was 38 (48.7 %) in anakinra and 36 (46.2 %) SoC (p=0.8). Overall, ICU admission was in 14.1 % (n=11) and 30.8 % (n=24) (p=0.013; OR: 6.2), intubation in 12.8 % (n=10) and 16.7 % (n=13) patients (p=0.5), 14.1 % (n=11) and 32.1 % (n=25) patients died in anakinra and control group, respectively (p=0.008; OR: 7.1)
Conclusion : In our study mortality was lower in patients receiving anakinra compared to SoC. Intravenous high dose anakinra is safe and effective treatment in patients with severe and critical COVID-19.
Automatic Enhancement Preprocessing for Segmentation of Low Quality Cell Images
Authors: Kato Sota , Hotta Kazuhiro
Published: January 2023

We present a novel automatic preprocessing and ensemble learning technique for the segmentation of low quality cell images. Capturing cells with strong light is difficult because cells die by strong light. Therefore, microscopic images of cells tend to be of low quality, which is unsuitable for semantic segmentation. This study presents automatic enhancement preprocessing (AEP), which translates an input image into images that are easy to recognize using deep learning. AEP consists of two deep neural networks. The first network is for semantic segmentation, and the penultimate feature maps of the first network are used as filters to translate an input image into images that are easily classified by a convolutional neural network. The two networks are trained in an end-to-end manner, and preparing high-quality images is not required for translation. Additionally, we combined the segmentation results using a weighted ensemble learning approach called automatic weighted ensemble learning (AWEL). Because the second network outputs the segmentation results corresponding to each translated input image, we can aggregate multiple segmentation results by automatically determining suitable weights using AWEL. Experiments on two types of cell image datasets confirmed that AEP can translate low-quality cell images into images that are easy to segment and that segmentation accuracy improves using AWEL. Our code is available at https://github.com/usagisukisuki/AEP .
Irreversible loss in marine ecosystem habitability after a temperature overshoot
Authors: Santana-Falcón Yeray , Yamamoto Akitomo , Lenton Andrew , Jones Chris , Burger Friedrich A. , John Jasmin , Tjiputra Jerry , Schwinger Jörg , Kawamiya Michio , Frölicher Thomas , Ziehn Tilo , Seferian Roland
Published: January 2023

Anthropogenic warming of the oceans and associated deoxygenation are altering marine ecosystems. Current knowledge suggests that these changes might be reversible in the centennial timescale in the ocean surface and irreversible at deeper depth if global warming were to decline. However, knowledge on the persistence of their combined effects on marine ecosystems remains limited. Here we explore to what extent global warming will drive alterations on marine habitats by following the evolution of a metabolic index that captures the ecophysiological response of marine organisms to both changes in temperature and oxygen, through an idealised ramp-up ramp-down atmospheric CO2 concentration experiment. Using a multi-model approach, we find that changes in ocean temperature and oxygen drives a centuries-long irreversible loss of ~4% in the habitable volume of the upper 1000 m of the world ocean. These results suggest the combined effect of warming and deoxygenation will diminish the capability of the ocean to hold life far after recovering from a temperature overshoot.
The association between psychosocial factors and mental health symptoms in cervical spine pain with or without radiculopathy on health outcomes: a systematic review
Authors: Mansfield Michael , Thacker Mick , Taylor Joseph , Bannister Kirsty , Spahr Nicolas , Jong Stephanie T. , Smith Toby
Published: January 2023

Background

Neck pain, with or without radiculopathy, can have significant negative effects on physical and mental wellbeing. Mental health symptoms are known to worsen prognosis across a range of musculoskeletal conditions. Understanding the association between mental health symptoms and health outcomes in this population has not been established. Our aim was to systematically review the association between psychosocial factors and/or mental health symptoms on health outcomes in adults with neck pain, with or without radiculopathy.

Methods

A systematic review of published and unpublished literature databases was completed. Studies reporting mental health symptoms and health outcomes in adults with neck pain with or without radiculopathy were included. Due to significant clinical heterogeneity, a narrative synthesis was completed. Each outcome was assessed using GRADE.

Results

Twenty-three studies were included (N = 21,968 participants). Sixteen studies assessed neck pain only (N = 17,604 participants); seven studies assessed neck pain with radiculopathy (N = 4,364 participants). Depressive symptoms were associated with poorer health outcomes in people with neck pain and neck pain with radiculopathy. These findings were from seven low-quality studies, and an additional six studies reported no association. Low-quality evidence reported that distress and anxiety symptoms were associated with poorer health outcomes in people with neck pain and radiculopathy and very low-quality evidence showed this in people with neck pain only. Stress and higher job strain were negatively associated with poorer health outcomes measured by the presence of pain in two studies of very low quality.

Conclusions

There is a negative association of mental health symptoms and health outcomes in people with neck pain, with or without radiculopathy. These findings are based on a small number of highly heterogenous, low- and very low-quality studies. Clinicians should continue to utilise robust clinical reasoning when assessing the complex factors impacting a person’s presentation with neck pain with or without radiculopathy.
PROSPERO registration number: CRD42020169497
Interleukin-4 improved adipose-derived stem cells engraftment via interacting with fibro/adipogenic progenitors in dystrophic mice
Authors: Li Huan , Lin Jinfu , Wang Liang , He Ruojie , Li Jing , Chen Menglong , Zhang Weixi , Zhang Cheng
Published: January 2023

Adipose-derived stem cells (ADSC) therapy is a promising therapy for dystrophinopathy. Fibro/adipogenic progenitors (FAP) are important in regulating the myogenesis of muscle satellite cells and contribute to muscle fibrosis and adipocyte infiltration. The interleukin-4 (IL4) pathway is found to be a switcher regulating the functions of FAP. The interaction between FAP and engrafted cells has not yet been studied. We used a co-culture system to investigate the possible crosstalk between FAP of dystrophic mice and IL4-overexpressed ADSC (IL4-ADSC) and control ADSC. The systemic transplantation of IL4-ADSC and control ADSC was conducted in dystrophic mice for 16 weeks and motor function and molecular improvements of mice were evaluated. Overexpression of IL4 in ADSC significantly promoted terminal myogenesis in vitro with significant increased expression of Myogenin and MyHC. Through co-culture, we discovered that myoblasts derived from control ADSC promoted adipogenic and fibrogenic differentiation of FAP, but FAP did not significantly affect their myogenesis, while overexpression of IL4 in ADSC inhibited their myotube-dependent promotion of FAP differentiation but promoted FAP to support myogenesis. Dystrophic mice delivered with IL4-ADSC-derived myoblasts had a significant better motor ability, more engrafted cells with dystrophin expression, less muscle fibrosis, and intramuscular adipocytes and macrophage infiltration than mice delivered with control-ADSC-derived myoblasts. Our results revealed the importance of focusing on the crosstalk between engrafted cells and resident FAP in cell therapy and the positive therapeutic effect of IL4 administration combined with ADSC therapy in dystrophic mice.
Real-time monitoring of fast gas dynamics with a single-molecule resolution by frequency-comb-referenced plasmonic phase spectroscopy
Authors: Kim Young-Jin , Nguyen Anh , Lee Geon-Ho , Kim San , Shin Dong-Chel , Kim Dae-Hee , Park Jongkyoon , Choi Hak-Jong , Kim Seung-Woo , Kim Seungchul
Published: January 2023

Surface plasmon resonance (SPR) sensors are based on photon-excited surface charge density oscillations confined at metal-dielectric interfaces, which makes them highly sensitive to biological or chemical molecular bindings to functional metallic surfaces. Metal nanostructures further concentrate surface plasmons into a smaller area than the diffraction limit, thus strengthening photon-sample interactions. However, plasmonic sensors based on intensity detection provide limited resolution with long acquisition time owing to their high vulnerability to environmental and instrumental noises. Here, we demonstrate fast and precise detection of noble gas dynamics at single molecular resolution via frequency-comb-referenced plasmonic phase spectroscopy. The photon-sample interaction was enhanced by a factor of 3,600 than the physical sample thickness owing to plasmon resonance and thermophoresis-assisted optical confinement effects. By utilizing a sharp plasmonic phase slope and a high heterodyne information carrier, a small atomic-density modulation was clearly resolved at 5 Hz with a resolution of 0.06 Ar atoms per nano-hole (in 10− 11 RIU) in Allan deviation at 0.2 s; a faster motion up to 200 Hz was clearly resolved. This fast and precise sensing technique can enable the in-depth analysis of fast fluid dynamics with the utmost resolution for a better understanding of biomedical, chemical, and physical events and interactions.
Understanding Spatial Historical and Future Landslide Variation in Africa
Authors: Nahayo Lamek , Cui Peng , Yu Lei , Tan Rongzhi
Published: January 2023

The African natural landscape reshaping in search for housing, food and infrastructure development exposes the slope to failure. However, the entire African landslide characterization is still not well known due to limited studies covering the whole continent. The authors recognize this fact and conduct this study to present the historical African landslide susceptibility (1990–2020) and the 2050 predicted occurrence under urbanization practices. Literature identifies 26,211 recent landslides and high number is localized within same areas highlighted by the 2006–2017 NASA landslide inventory. For periodical landslide susceptibility mapping, rainfall, urbanization and LULC are selected as major drivers based on literature and inventory. Each of these factors’ historical maps are estimated to date (2022). These factors are combined with elevation, slope, aspects, curvature, distance to roads, distance to rivers, distance to faults, soil moisture, soil texture and lithology as of 2022 to estimate the current (2022) spatial landslide susceptibility. The Information Gain Ratio sensitivity analysis highlights urbanization (0.106), LULC (0.097), slope (0.091), elevation (0.088) and rainfall (0.083) as key landslide drivers. The Southern and Horn of Africa record above 80% of high and very high susceptibility classes. This 2022 susceptibility map is then predicted to 2050 and reclassified as that of 2050 urbanization (base map). The Southern, Eastern, Northern and Horn of Africa are landslide prone areas. This new study helps policy makers to ensure proper land planning and management practices for sustainable urbanization and lowering loss on human lives, damage on properties and environment.