bluuebunny/crossref_metadata_2025 huggingface dataset:
A Phenomenological Analysis on Evaluation of Sports Management Department Curriculum by Sports Sciences Faculty Members
Authors: Araç Ilgar Ebru , Cihan Bekir Barış
Published: December 2018

The aim of this study is evaluating the curriculum of sports management department, which is offered by sportssciences faculties and schools of physical education and sports, by faculty members. With this study, which isconstructed on qualitative research methods and a phenomenological pattern, instead of statistical generalizations,analytical generalizations were performed, a hypothesis was formed and hypothetical theorems were proposed.“Convenience Sampling”, which is a form of purposive sampling, was chosen as the method of sampling.Semi-structured interview forms were used during data collection. Interview data were put down on paper andorganized, and themes were created by determining meaningful data. In accordance with the themes, categories wereformed and findings were extracted. In the light of obtained data, faculty members point out that the existingcurriculum helps students’ professional development with theoretical classes such as sports law, sports economy,administration, economics and sports management. In contrast, they also mentioned negative aspects of thecurriculum such as scarcity of applied classes, inadequate sports facilities, lack of sectoral collaboration andinefficiency of sports management applications. It is envisioned that findings of this study will improve thepreparation and organization processes of sports management curriculums of sports sciences faculties and schools ofphysical education and sports.
Cancer Related Fatigue and Optimism in Cancer Patients
Authors: Strebkova Raisa , Petkova Miroslava Petkova
Published: December 2018

Summary: The symptoms of fatigue and exhaustion are considered to be the most common complaints amongpatients with malignant diseases during the process of treatment and upon its completion. The manifestations offatigue can be physical, cognitive and emotional. Particularly interesting are the risk factors for the emergence offatigue which persists for months or years upon the completion of the treatment. A number of studies have discussedthe significance of the psychological factors such as the personality traits, the person’s behaviour and the lifestyle.Objective: To examine the burden of fatigue among patients with malignant diseases undergoing radiotherapy andlong-term survivors and determine the effect of optimism on the burden of fatigue among them. Method: Aquestionnaire; MFI-20-A multidimensional questionnaire on fatigue; Method of examining the generalizedexpectations about the valence of the obtained results. 66 people with a confirmed oncological diagnosis wereincluded in the study, 36 of whom were undergoing radiotherapy at the time of the study. 30 of the examined peoplehave undergone radiotherapy and are presently long-term survivors who have lived over five years after beingdiagnosed with the disease. Conclusion: The patients that were undergoing radiotherapy at that time manifestedmore evident symptoms of fatigue within the dimensions of decreased motivation and decreased activity compared tothe patients belonging to the group of the long-term survivors. Optimism and the negative expectations correlatesignificantly with the dimensions of fatigue in both groups of patients, as the most obvious is the negative correlationof optimism with the decreased activity and the decreased motivation. The presence of optimism and low negativeexpectations within the personality profile of patients with oncological diseases suggests lower levels of fatigueregardless of the stage of the disease and the conducted treatment.
Comparing Different Systemic Risk Measures for European Banking System
Authors: Di Clemente Annalisa
Published: December 2018

This research examines and compares the performances in terms of systemic risk ranking for three different systemic risk metrics based on daily frequency publicly available data, specifically: Marginal Expected Shortfall (ES), Component Expected Shortfall (CES) and Delta Conditional Value-at-Risk (ΔCoVaR). We compute ΔCoVaR, MES and CES by utilizing EVT principles for modelling marginal distributions and Student’s t copula for describing the dependence structure between every bank and the banking system. Our objective is to attest whether different systemic risk metrics detect the same banks as systemically dangerous institutions with refer to a sample of European banks over the time span 2004-2015. For each bank in the sample we also calculate three traditional market risk measures, like Market VaR, Sharpe’s beta and the correlation between every bank and the banking system (European STOXX 600 Banks Index). Another aim is to explore the existence of a link among systemic risk measures and traditional risk metrics. In addition, the classification results obtained by the different risk metrics are compared with the ranking in terms of systemic riskiness (for European banks) calculated by Financial Stability Board (2015) using end-2014 data and collected in its list of Global Systemically Important Banks (G-SIBs). With refer to the entire sample period, we find a good coherence of ranking results among the three different systemic risk metrics, in particular between CES and ΔCoVaR. Moreover, we find for MES and ΔCoVaR a strong linkage with beta and correlation metrics respectively. Finally, CES metric shows the highest level of concordance with the list of G-SIBs by FSB with refer to European banks.
A STUDY OF AREA AND THICKNESS COMPRESSION OF PARAFFIN SECTIONS
Authors: Xiang Yu , Guo Yang , Yang Zheng-Wei
Published: December 2018

This study was carefully designed to determine the section compression of paraffin embedded sections. Two sections (one with thickness 5 µm and one 10 µm set by microtome) were cut from each of 2 sets of 12 testicular tissue (adult rats) blocks and stained with hematoxylin. Using scanned images, the area and the vertical (along the sectioning direction) and horizontal diameters of the block face were measured and compared with those of the unstained, stained or coverslipped section. Using the coverslipped section, the vertical and horizontal diameters of round spermatid nuclear profiles and the actual thickness of section were measured with light microscopy. Overall, the area of the coverslipped section was reduced by 5.5%-8.6% (on average) in comparison with that of the block face, with 69.5%-84.4% of the reduction being contributed by section compression in the process of section cutting, mounting and drying. The vertical (linear) compression of section, the primary cause of section area compression, was 5.9%-8.9%. The vertical compression of nuclear profiles was 1.5%-2.3% in 2 sets of sections and 5.2%-5.7% in other sections, indicating a non-uniform compression of structures within some sections depending on procedures of section drying. The measured mean thickness of sections decreased by 3.1%-5.0%.
A 3D STOCHASTIC MODEL FOR GEOMETRICAL CHARACTERIZATION OF PARTICLES IN TWO-PHASE FLOW APPLICATIONS
Authors: De Langlard Mathieu , Lamadie Fabrice , Charton Sophie , Debayle Johan
Published: December 2018

In this paper a new approach to geometrically model and characterize 2D silhouette images of two-phase flows is proposed. The method consists of a 3D modeling of the particles population based on some morphological and interaction assumptions. It includes the following steps. First, the main analytical properties of the proposed model – which is an adaptation of the Matérn type II model – are assessed, namely the effect of the thinning procedures on the population’s fundamental properties. Then, orthogonal projections of the model realizations are made to obtain 2D modeled images. The inference technique we propose and implement to determine the model parameters is a two-step numerical procedure: after a first guess of the parameters is defined, an optimization procedure is achieved to find the local minimum closest to the constructed initial solution. The method was validated on synthetic images, which has highlighted the efficiency of the proposed calibration procedure. Finally, the model was used to analyze real, i.e., experimentally acquired, silhouette images of calibrated polymethyl methacrylate (PMMA) particles. The population properties are correctly evaluated, even when suspensions of concentrated monodispersed and bidispersed particles are considered, hence highlighting the method’s relevance to describe the typical configurations encountered in bubbly flows and emulsions.
ON THE PRECISION OF THE ISOTROPIC CAVALIERI DESIGN
Authors: González-Villa Javier , Cruz Marcos , Cruz-Orive Luis M.
Published: December 2018

The isotropic Cavalieri design is based on a isotropically oriented set of parallel systematic sections a constant distance apart. Its advantage over the ordinary Cavalieri design is twofold - first, besides volume it allows the unbiased estimation of surface area, and second, the error variance predictor for the volume estimator is much simpler, involving only the surface area of the object, and the distance between sections. In an earlier paper, the two hemispheres of a rat brain were arranged perpendicular to each other before sectioning, aiming at reducing the error variance with respect to other arrangements (such as the aligned one) by exploiting an intuitively plausible antithetic effect. Because the total surface area of the objects is unchanged under any arrangements, however, the error variance predictor for the volume estimator does not depend on object shape, which looks intriguing. Using reconstructions of the mentioned hemispheres, we dilucidate the aparent paradox by means of automatic Monte Carlo replications of the relevant volume estimates under the antithetic and the aligned arrangements.
Tubylcy i nomadzi. Serialowe spektakle tożsamości narodowej Polaków
Authors: Kisielewska Alicja
Published: December 2018

The subjects of this article are Polish television series as spectacles of Polish national identity, presenting and broadcasting various indications of national representation. The author reflects upon popular XXI century drama series, realized by main TV broadcasts in Poland (TVP1, TVP2, Polsat, TVN), minimum two seasons executed of each series. The starting point is a thesis of ubiquitous contemporary nations as imagined communities, and at the same time, that national identity is becoming more and more problematic and unstable. The main goal of this article is to analyze how TV series are creating, consolidating and shaping Polish national identity, in context of social migration processes and mediatization of experiences. The author will analyze habits, rituals and everyday practices shown in TV series as an area of shaping national identity. National identity becomes then a construct, a project, a spectacle, in creation of which television plays an important role, being a significant source of social imagination.
Technologie self, czyli „programowanie” dryfujących tożsamości
Authors: Kalinowska Anna
Published: December 2018

How to define an identity? As a product of individual or result of social and cultural influences through the ages? One, main and only answer could not exist. Ones identity in post-modern reality will be elusive. From time to time, from information or network to alghorithmic society some new identity concepts have appeared. But it is a fact that the category of identity becames smooth and undefined nowadays. We all have its plural. Technologies of self may be a solution to search for specific identity settings. Looking at actions and attitudes that lead to the realization of the goals and self-improvement, technologies of self represent the modern coordinates of identity formation. The use of analog and digital tools makes it possible to control and characterize the factors forming ones personality. In the end, it is expressed as media practices. This article is an essay to redefine the concept of technologies of self, including digital return during last 20 years. The conclusions are based on the analysis of the author’s qualitative research. The paper presents a short specification of the definitions focused on daily on-line activities and user habits.
Opinie polskich pracowników o wynagrodzeniu minimalnym i ich konteksty w mediach
Authors: Wasilewski Jacek , Werner Aleksander , Kimla Katarzyna , Kostrzewa Agata
Published: December 2018

Celem artykułu jest przedstawienie opinii polskich pracowników dotyczących: minimalnego wynagrodzenia w odniesieniu do roli tego wynagrodzenia jako instrumentu polityki społecznej, treści medialnych o relacji pracownika z pracodawcą oraz poczucia sprawiedliwości społecznej. Analiza naświetla minimalne wynagrodzenie pod kątem sytuacji prawnej, aspektów polityki społecznej oraz narracji pojawiających się w mediach. W artykule zostały przedstawione wyniki badania opinii przeprowadzonego na reprezentatywnej grupie Polaków. Na podstawie ich analizy można wnioskować, że minimalne wynagrodzenie w opinii respondentów powinno być ukształtowane na poziomie pozwalającym przeżyć, co może rodzić pytania o jego indywidualizację i dywersyfikację w zależności od indywidualnych cech pracującego.
A review of the South American genera of Cimbicidae (Insecta, Hymenoptera)
Authors: Vilhelmsen Lars , Smith David R. , Malagòn-Aldana Leonardo A.
Published: December 2018

The South American genera of the Cimbicidae are reviewed. Five genera and nine species are recognized. Redescriptions of all genera and an identification key to all species are provided. All species are illustrated, including both sexes and aberrant specimens when relevant. The South American Cimbicidae are grouped in the subfamily Pachylostictinae, but there is substantial morphological divergence at the genus level. This and the isolated geographic and phylogenetic position relative to the other subfamilies of Cimbicidae indicates that the Pachylostictinae have evolved in isolation for a substantial amount of time. Host plant records are known for only one species, Pseudopachylosticta subflavata, which is mainly found in the Chacoan subregion. The distribution of the remaining species falls almost exclusively within the range of the Parana subregion forest provinces, a biome that has been much reduced by human activity in the past half millennium. It is likely that these rarely collected wasps are threatened by habitat degradation.
Nova abordagem para a estimativa do fluxo de calor no solo para o Bioma Pampa
Authors: Romio Leugim Corteze , Zimmer Tamíres , Roberti Débora Regina , Buligon Lidiane
Published: December 2018

The study of the thermal properties of the soil and the variables dependent on these properties is very important for the understanding of the surface energy balance. Among the main variables, there is the soil heat flux, especially because it allows the verification of the influences that occur in the biome of a region as temperature variation occurs. This work intend to estimate the coefficient of thermal conductivity and, thus, to obtain the values for the soil heat flux. The data used to estimate the parameters were obtained from an experimental site located in the city of Pedras Altas-RS. Two equations were used, the first one defined by the Fourier Heat Conduction Law (discretized) and the second one a modification of the first one including a k coefficient, named “modeling error”. Based on the results obtained it can be verified that the modified equation presented better results, when compared with the classical solution.
Estudo das técnicas de preenchimento para dados de fluxo de metano em uma área de arroz irrigado por inundação
Authors: Fagundes Lucas Augusto , Maboni Cristiano , Pinheiro Maria Eduarda , Sehnem Josue , Diaz Marcelo , Roberti Debora Regina
Published: December 2018

Studies on the emission of methane gas (CH4) in agricultural ecosystems have received attention from the scientific communitybecause it plays an important role in the greenhouse effect. Flood irrigation agriculture, such as irrigated rice, represents aconsiderable source of methane emissions (from 12 to 26 percent of all anthropogenic CH4 emissions in the world). Estimates ofCH4 emissions have also been performed through the eddy covariance technique. Although this methodology makes continuousmeasurements of methane exchanges between the ecosystem and the atmosphere, failure to collect data can occur because thesystem is quite sensitive, especially in the hard weather conditions. The gap filling in the methane data are essential to obtaina daily or seasonal quantification of the emissions. In this study, different gap filling techniques are used to fill the CH4 fluxesobtained by eddy covariance technique in an irrigated rice crop. The experimental data were obtained in Cachoeira do Sul - RS inthe period from 11/20/2015 to 04/30/2016. The Look-Up Table (LUT), which consists of filling gaps using averages of flux valuesfor periods with similar atmospheric conditions, was the technique that best close the gap in methane fluxes data.
Comparação entre dois modelos de função footprint aplicados ao sítio experimental de Pedras Altas
Authors: Bremm Tiago , Toro Ivan Mauricio Cely , Veeck Gustavo Pujol , Roberti Débora Regina , Buligon Lidiane
Published: December 2018

Micrometeorological towers are installed in several regions in order to collect atmospheric data at high frequency for the estimation of micrometeorological parameters and surface flows of energy and mass. The determination of the towers field of view and, therefore, the flow measured at the sensors is defined by the footprint, which is directly influenced by the geometry of the terrain and by the vegetation of the site on which the sensor is installed. In this way, the present work aims to analyze the predominant area of the flow contribution by two different methods of footprint determination: one analytical model and one lagrangian stochastic. The data were analyzed for the micrometeorological station of Pedras Altas, located in the south western region of Rio Grande do Sul. The results show that the stochastic model considers the tower field of view closer than the analytical model, consequently it covers a smaller area.
Perfis verticais dos espectros das velocidades turbulentas em uma torre micrometeorológica de 140 m
Authors: Acevedo Otávio Costa , Oliveira Pablo Eli Soares de , Teichrieb Claudio Alberto , Puhales Franciano Scremin , Martins Luis Gustavo Nogueira , Degrazia Gervásio Annes , Silva Samuel Martins , Maroneze Rafael
Published: December 2018

Multiresolution spectra of both horizontal and vertical wind components observed at a 140-m micrometeorological tower are analysed. The tower is located at the township of Linhares, ES, Brazil, at 4 km from the coast and nest to a thermal power plant. At nighttime, the spectral maximum is located at the largest temporal scales analyzed, being therefore related to nonturbulent low-frequency processes. During the day, spectral maxima of the horizontal wind components show little variation above 20 m.For the vertical component, on the other hand, the temporal scale of such maxima increases steadily with height.
A PERFORMANCE NA ESCOLA: EVIDENCIANDO LIMITES E POSSIBILIDADES
Authors:   Universidade Federal de Minas Gerais, Santos Isabella Fernanda
Published: December 2018

A Arte é um componente curricular da Educação Básica brasileira e seu ensino/aprendizagem contempla inúmeras expressões artísticas da Dança, do Teatro, das Artes Visuais e da Música. A performance é uma expressão artística muito relevante e recorrente na contemporaneidade e se insere nas lógicas das artes pública e conceitual, podendo ampliar a aproximação entre público e arte, assim como o cruzamento de diversas outras expressões contemporâneas. O ensino/aprendizagem da performance na escola é um desafio, pois evidencia diversas questões e problemas em relação a métodos de ensino/aprendizagem e organização escolar na atualidade. Pensar o corpo como suporte para a arte traz à tona inúmeras questões importantes para a arte contemporânea, questões que devem ser levadas para as aulas de Arte. Este artigo apresenta e discute algumas experiências com a performance no ensino/aprendizagem de Arte em uma escola pública. Essas práticas se relacionam diretamente com a poética do artista/professor e levantam questões sobre as tensões existentes entre arte e ensino/aprendizagem, como a arte se apresenta na escola e quais são suas possibilidades e limitações nesse contexto.
CONSERVATÓRIOS ESTADUAIS MINEIROS: DA FORMAÇÃO DE PROFESSORES DE MÚSICA A PROJETOS, PARCERIAS E CAPACITAÇÃO DOCENTE PARA O ENSINO BÁSICO
Authors: Alves Denise Coimbra
Published: December 2018

Neste recorte de minha dissertação de Mestrado (Prof-Artes), sintetizo a cronologia das ações da Secretaria de Estado da Educação de Minas Gerais, que envolveram os Conservatórios Estaduais de Música, com definidos propósitos de atendimento à escolarização básica obrigatória, desde a formação de Professores de Música, seguida de projetos e parcerias. Concluo com o relato de minha participação na elaboração, implantação e como professora do Curso de Extensão em Educação Musical, em 2012, no Conservatório Estadual de Juiz de Fora, destinado à capacitação de professores estaduais não especialistas em Música, para inserção da Música no âmbito escolar em cumprimento da Lei n. 11.769/2008.
Too Much Academic Research Is Being Published
Authors: Altbach Philip G. , De Wit Hans
Published: December 2018

There is a crisis in academic publishing and in the global knowledge-distribution system in general—there is too much pressure on top journals, there are too many books and articles of marginal quality, predatory journals are on the rise, and there is a tremendous pressure on academics worldwide to publish. We propose recognizing that most universities and most academics, globally, focus on teaching, and that the large majority of universities acknowledge their important roles as teaching-focused and do not seek to become research-intensive institutions. We call for quality, but also for control of what quality is, by the academic community instead of by nonacademic rankers, publishers, and citation and impact measurers. Quality—not quantity—should be the objective, in combination with an effort to bring quality control back into the academic community—while making sure that that control is not dominated by small groups in research universities in the rich countries.
Italy: Brain Drain or Brain Circulation?
Authors: Saint-Blancat Chantal
Published: December 2018

Giving a Voice to Italian Scientists in Europe, a research project based on 83 in-depth interviews and a subsequent online survey, shows that transforming brain drain into brain circulation or into a potential scientific diaspora is not an easy task. Overturning Italy’s low level of investment in R&D and building reciprocal acknowledgment and trust between scientists abroad and in their country are identified as prerequisites for this transformation.
International Faculty in Japan
Authors: Huang Futao
Published: December 2018

The 1979 and 2017 national surveys of full-time international faculty at Japanese universities show numerous important changes. The proportion of female academics has increased, and Japanese universities hire more international faculty in high academic positions, doing research in the hard sciences, and originating from China and Korea. Today, the vast majority of international faculty come to Japan for academic reasons, and have more positive perceptions of the Japanese academic market and their Japanese colleagues.
National Policies and the Role of English in Higher Education
Authors: Liu Xinyan
Published: December 2018

Past research and debate on the use of English in higher education has mostly focused on northern European countries, as they were among the first to consider using English as a language of instruction. This paper seeks to broaden the topic by focusing on a diverse group of countries including Brazil, France, Malaysia, South Africa, and Spain. The two key aspects discussed here concern existing national policies regarding language in higher education in the target countries and the role of English in their respective higher education systems.
China–US Cooperation in Higher Education: A Critical Stabilizer
Authors: Postiglione Gerard A. , Simon Denis
Published: December 2018

The world’s two leading economies have hit a rough patch that has begun to spill over into their 40 years of cooperation in higher education. At stake is the ability of their universities to be instruments of global integration, mutual understanding, and geopolitical stability.
Controllability of degenerate and singular parabolic problems: the double strong case with Neumann boundary conditions
Authors: Fragnelli Genni , Mugnai Dimitri
Published: December 2018

We prove a null controllability result for a parabolic problem with Neumann boundary conditions. We consider non smooth coefficients in presence of a strongly singular potential and a strongly degenerate coefficient, both vanishing at an interior point. This paper concludes the study of the Neumann case.
Extremal length and Dirichlet problem on Klein surfaces
Authors: Roşiu Monica
Published: December 2018

The object of this paper is to extend the method of extremal length to Klein surfaces by solving conformally invariant extremal problems on the complex double. Within this method we define the extremal length, the extremal distance, the conjugate extremal distance, the modulus, the reduced extremal distance on a Klein surface and we study their dependences on arcs.
Glucose intake hampers PKA-regulated HSP90 chaperone activity
Authors: Chen Yu-Chen , Jiang Pei-Heng , Chen Hsuan-Ming , Chen Chang-Han , Wang Yi-Ting , Chen Yu-Ju , Yu Chia-Jung , Teng Shu-Chun
Published: December 2018

Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are still elusive. Here, we conducted a quantitative mass spectrometry screen and identified all phosphorylation/dephosphorylation sites on yeast proteins that significantly responded to calorie restriction, a well-established approach to extend lifespan. Functional screening of 135 potential regulators uncovered that Ids2 is activated by PP2C under CR and inactivated by PKA under glucose intake. ids2Δ or ids2 phosphomimetic cells displayed heat sensitivity and lifespan shortening. Ids2 serves as a co-chaperone to form a complex with Hsc82 or the redundant Hsp82, and phosphorylation impedes its association with chaperone HSP90. Thus, PP2C and PKA may orchestrate glucose sensing and protein folding to enable cells to maintain protein quality for sustained longevity.
Auxiliary subunits keep AMPA receptors compact during activation and desensitization
Authors: Baranovic Jelena , Plested Andrew JR
Published: December 2018

Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers. Technical advances in cryo-electron microscopy brought a slew of full-length structures of AMPA receptors, on their own and in combination with auxiliary subunits. These structures indicate that dimers might undergo substantial lateral motions during gating, opening up the extracellular layer along the central twofold symmetry axis. We used bifunctional methanethiosulfonate cross-linkers to calibrate the conformations found in functional AMPA receptors in the presence and absence of the auxiliary subunit Stargazin. Our data indicate that extracellular layer of AMPA receptors can get trapped in stable, opened-up conformations, especially upon long exposures to glutamate. In contrast, Stargazin limits this conformational flexibility. Thus, under synaptic conditions, where brief glutamate exposures and the presence of auxiliary proteins dominate, extracellular domains of AMPA receptors likely stay compact during gating.
Promoting subjective preferences in simple economic choices during nap
Authors: Ai Sizhi , Yin Yunlu , Chen Yu , Wang Cong , Sun Yan , Tang Xiangdong , Lu Lin , Zhu Lusha , Shi Jie
Published: December 2018

Sleep is known to benefit consolidation of memories, especially those of motivational relevance. Yet, it remains largely unknown the extent to which sleep influences reward-associated behavior, in particular, whether and how sleep modulates reward evaluation that critically underlies value-based decisions. Here, we show that neural processing during sleep can selectively bias preferences in simple economic choices when the sleeper is stimulated by covert, reward-associated cues. Specifically, presenting the spoken name of a familiar, valued snack item during midday nap significantly improves the preference for that item relative to items not externally cued. The cueing-specific preference enhancement is sleep-dependent and can be predicted by cue-induced neurophysiological signals at the subject and item level. Computational modeling further suggests that sleep cueing accelerates evidence accumulation for cued options during the post-sleep choice process in a manner consistent with the preference shift. These findings suggest that neurocognitive processing during sleep contributes to the fine-tuning of subjective preferences in a flexible, selective manner.
The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage
Authors: Jeong Eutteum , Brady Owen A , Martina José A , Pirooznia Mehdi , Tunc Ilker , Puertollano Rosa
Published: December 2018

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets. TFE3 and TFEB contribute to sustain p53-dependent response by stabilizing p53 protein levels. In TFEB/TFE3 DKOs, p53 half-life is significantly decreased due to elevated Mdm2 levels. Transcriptional profiles of genes involved in lysosome membrane permeabilization and cell death pathways are dysregulated in TFEB/TFE3-depleted cells. Consequently, prolonged DNA damage results in impaired LMP and apoptosis induction. Finally, expression of multiple genes implicated in cell cycle control is altered in TFEB/TFE3 DKOs, revealing a previously unrecognized role of TFEB and TFE3 in the regulation of cell cycle checkpoints in response to stress.
Drought adaptation in Arabidopsis thaliana by extensive genetic loss-of-function
Authors: Monroe J Grey , Powell Tyler , Price Nicholas , Mullen Jack L , Howard Anne , Evans Kyle , Lovell John T , McKay John K
Published: December 2018

Interdisciplinary syntheses are needed to scale up discovery of the environmental drivers and molecular basis of adaptation in nature. Here we integrated novel approaches using whole genome sequences, satellite remote sensing, and transgenic experiments to study natural loss-of-function alleles associated with drought histories in wild Arabidopsis thaliana. The genes we identified exhibit population genetic signatures of parallel molecular evolution, selection for loss-of-function, and shared associations with flowering time phenotypes in directions consistent with longstanding adaptive hypotheses seven times more often than expected by chance. We then confirmed predicted phenotypes experimentally in transgenic knockout lines. These findings reveal the importance of drought timing to explain the evolution of alternative drought tolerance strategies and further challenge popular assumptions about the adaptive value of genetic loss-of-function in nature. These results also motivate improved species-wide sequencing efforts to better identify loss-of-function variants and inspire new opportunities for engineering climate resilience in crops.
Stem cells repurpose proliferation to contain a breach in their niche barrier
Authors: Lay Kenneth , Yuan Shaopeng , Gur-Cohen Shiri , Miao Yuxuan , Han Tianxiao , Naik Shruti , Pasolli H Amalia , Larsen Samantha B , Fuchs Elaine
Published: December 2018

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt barrier function, adjacent stem cells dramatically change their transcriptome independent of bacterial invasion and become capable of directly signaling to and recruiting immune cells. Additionally, these stem cells elevate cell cycle transcripts which reduce their quiescence threshold, enabling them to selectively proliferate within this microenvironment of immune distress cues. However, rather than mobilizing to fuel new tissue regeneration, these ectopically proliferative stem cells remain within their niche to contain the breach. Together, our findings expose a potential communication relay system that operates from the niche to the stem cells to the immune system and back. The repurposing of proliferation by these stem cells patch the breached barrier, stoke the immune response and restore niche integrity.
Evangelisk ironi
Authors: Gaasland Rolf
Published: December 2018

This article addresses the question whether unreliable narration, as the concept is understood in the tradition following Wayne Booth’s original definition, can occur in non-fictional stories. Contrary to Pekka Tammi’s conclusion in a recent article, this article’s answer is affirmative. It seeks to demonstrate, through a comparative analysis of respectively Mark’s and Matthew’s stories about the Canaanite woman (Mark 7:24–30 and Matthew 15:21–28), how Matthew comes forward as an unreliable narrator, and that his narrative unreliability is a function of what James Phelan has termed underreporting. The textual analysis, which leans on Gregory Currie’s and James Phelan’s theories of unreliable narration, argues that far from being more or less identical stories, as is suggested by various exegetes, Matthew’s pericope is significantly different from that of Mark. It is different both thematically and regarding the portrayal of the figure of Jesus, but also, and not least, by pursuing a more complex and daring communicative strategy based on unreliable narration and a system of multilayered irony. In concluding the theoretical discussion of unreliable narration, I suggest not only that unreliable narration is possible in non-fictional stories, but also that it is a somewhat misleading concept when applied to the kind of stories Wayne Booth normally referred to, namely fictional first-person narratives.
Arkeologiske undersøkelser ved Láksjohka, Tana kommune, Finnmark 2004
Authors: Skandfer Marianne
Published: December 2018

Archaeological field report (in Norwegian) from registration and test-pitting at Láksjohka, Deatnu/Tana municipality, Finnmark. Includes background, methods, observations and AMS-dates. Illustrated.Report from the same site 2006: http://doi.org/10.7557/7.4313Report from the same site 2007: http://doi.org/10.7557/7.4334
Arkeologiske undersøkelser på Kjerringneset, Sør-Varanger kommune, Finnmark 2004
Authors: Skandfer Marianne
Published: December 2018

Excavation report in Norwegian. Investigations of two lage, rectangular house-pits. Both had hearth-areas along the long mid-axis similar to so-called "Gressbakken houses". Radiocarbon dates from different layers in the hearths showed re-use: dates fall into the second millennium BC and around BC/AD. Under the wall in one of the houses were older flakes and tool fragments, belonging to an older settlement phase. It cannot be said if this was related to a house structure.Related publication:Skandfer, M. 2012. " Change and Recollection: House Structures and Social Identification in Finnmark, Artic Norway 2400 BC - AD 300." In Damm, Charlotte and Saarikiivi, Janne (eds.): Networks, Interaction and Emerging Identities in Fennoscandia and Beyond. Papers from the Conference held in Tromsø, Norway, October 13-16 2009. Suomalais-Ugrilainen Seura / Finno-Ugrian Society 2012 pp. 155-176 (2017-06-12)Related reports:http://doi.org/10.7557/7.4314http://doi.org/10.7557/7.4312http://doi.org/10.7557/7.4313http://doi.org/10.7557/7.4334http://doi.org/10.7557/7.4333
Rapport fra utgravning: "Fosslund" (g.nr. 16/1), Sør-Varanger k., Finnmark
Authors: Skandfer Marianne
Published: December 2018

Excavation report. Excavation of house-pit at "Fosslund" in Pasvik River Valley 2000, as part of PhD project. Trench through wall and floor, uncovering a fire-pit with clay (some possibly from vessels) and burnt bones and quartz. Some quartz scrapers and flakes in floor area. Radiocarbon dated to 405–205 BC and 200–35 BC.Related publication:Skandfer, M. 2012. " Change and Recollection: House Structures and Social Identification in Finnmark, Artic Norway 2400 BC - AD 300." In Damm, Charlotte and Saarikiivi, Janne (eds.): Networks, Interaction and Emerging Identities in Fennoscandia and Beyond. Papers from the Conference held in Tromsø, Norway, October 13-16 2009. Suomalais-Ugrilainen Seura / Finno-Ugrian Society 2012 pp. 155-176 (2017-06-12)Related reports:http://doi.org/10.7557/7.4334http://doi.org/10.7557/7.4311http://doi.org/10.7557/7.4314http://doi.org/10.7557/7.4313
Teaching Phrasal Verbs More Efficiently: Using Corpus Studies and Cognitive Linguistics to Create a Particle List
Authors: Spring Ryan
Published: December 2018

Phrasal verbs are important for EFL and ESL education because of their high frequency, but can be difficult for learners because of their number and polysemy. While there are a number of studies on phrasal verbs, the widening focus of such studies has left a gap between theory and practical instruction. This study improves upon previous studies related to teaching phrasal verbs through cognitive linguistics by combining the theory of event conflation with corpus-based research to create a list of phrasal verb particles and meanings that is concise and yet comprehensive enough to account for approximately 95% of common phrasal verb meanings. It also reports the results of an experiment in which learners taught with this particle list improved more on pre-/post-tests of phrasal verbs than learners that studied a list of the most common phrasal verbs as whole entities (p<0.001, d=1.34). Quantitative and qualitative data presented in this study also indicate that learners taught with the particle list improved their ability to conjecture the meanings of novel phrasal verbs more effectively than learners who studied common phrasal verbs as whole units.
The Impact of Teaching EFL Medical Vocabulary Through Collocations on Vocabulary Retention of EFL Medical Students
Authors: Najafi Maryam , Talebinezhad Mohammad Reza
Published: December 2018

Teaching technical vocabulary in ESP context is a vital part of English language teaching at a university level. EFL teachers almost use traditional techniques for teaching new medical vocabulary. This study aimed at examining the impact of teaching medical vocabulary through collocations on vocabulary learning of medical students. This quasi-experimental study with a pretest/posttest control group design was conducted on 80 students majoring Nursing at Kashan University of Medical Sciences, Iran. The proficiency test was used to determine the proficiency level of the students and 62 students were selected as intermediate students. The students were assigned into two groups. In the experimental group new medical vocabulary was taught through collocations, while in the control group new vocabularies were instructed through traditional techniques including synonym, antonym, definition and mother tongue translation. Data were collected using a researcher-made test of collocation. Results showed that the mean score of teaching medical vocabulary was increased in the experimental group after the treatment. It can be seen that the experimental group outperformed the control group on the medical collocation tests.
Implementing Poetry in the Language Class: A Poetry-Teaching Framework for Prospective English Language Teachers
Authors: Kuru Gönen Safiye İpek
Published: December 2018

Poetry has often been neglected as a favorable tool for language teaching. What is more, its role to expand human experience and create language awareness has not been fully realized. As a reaction to often-underestimated value of including literature in the language class, this article proposes a poetry-teaching (POT) framework for language practitioners to bridge the gap between literature and language teaching methodology. Step-by-step procedure followed in the framework aimed at helping prospective teachers incorporate poetry into language teaching, while at the same time offering various materials and activities to be used in their future teaching practices. The proposed framework was presented to 21 student teachers at an English Language Teaching (ELT) department of a state university in Turkey to help them integrate the ideas of using poetry in a micro-teaching context. Prospective teachers acted both as learners and teachers while following the steps of the suggested framework, and reflected on this experience through reflective diaries and stimulated recalls of their teaching performances. They also took part in semi-structured interviews at the end of the study. Qualitative analyses revealed that poetry can have a place in language teaching by using a systematic and guided framework tailored to the features of a language classroom. With the help of the proposed framework, implementing poetry in the language class helped to promote motivation, creativity and self-expression along with multi-skill development and interaction among learners. However, incorporating poetry into the language class was challenging in terms of time and effort required and difficulties in material selection and design. This study suggests that poetry can become part of language teacher education. In this regard, this article proposes implications for teachers and teacher educators for the implementation of poetry in language teaching practice.
An Experimental Documentary: Making a Case for Baird’s Modernism
Authors: Adedipe Ademolawa Michael
Published: December 2018

The refutation and the obliteration of the modernist era in Canadian literature by Robert Kroetsch and reasserted by Glen Wilmott makes it imperative to look at highly experimental literary works in the first half of the 20th century in Canada. The purpose of this paper, thus is to make a case for the inclusion Irene Bird’s Waste Heritage in the repertoire of modernist works in North America. The various criticism of Canadian literature as not having a modernist era needs to be debunked. The false assertion that Canadian literature moved straight from the Victorian era to a postmodernist face is probably due to the difficulty of defining what modernism is. The evolution and the expansion of the term modernism makes it imperative for one to reappraise the creative works of Irene Bird (Waste Heritage) and Sheila Watson (Double Hook) as modernist. An attempt to include Waste Heritage in the new modernist discourse of global literature by looking at the experimental way by which Baird used documentary modernism. The sustainability of a growing modern society vis-à-vis modernism, and the resistance of capitalism in Baird’s narrative would be used to make a case for Baird’s modernism.
An LFG Analysis of Gapping Constructions in Taif Arabic
Authors: Alzaidi Muhammad Swaileh A.
Published: December 2018

We identify and propose an analysis in LFG of Gapping construction in Taif “Hijazi” Arabic (TA). Gapping occurs in a coordination structure where the initial conjunct is syntactically complete and the non-initial conjunct is incomplete. To my knowledge, there is no previous description or analysis of gapping in TA. There have been two competing analyses in the literature on gapping, which view gapping as a result of a trace of movement and non-constituent coordination. In this paper, we show that none of these approaches succeeds to account for Gapping in TA, and hence, they fail to capture the facts of gapping in this Arabic dialect. Instead, we adopts a function-spreading approach within Lexical-Functional Grammar (LFG), and show how it is able to account for the facts of gapping in TA, using mechanisms proposed independently for other construction types.
Association between dry eye disease and asthma: a nationwide population-based study
Authors: Huang Yung-Chieh , Chan Wei-Cheng , Wang Jiaan-Der , Fu Lin-Shien , Tsan Yu-Tse
Published: December 2018

Background

Dry eye disease (DED), a chronic ocular disease, is associated with numerous medical issues, including asthma. However, studies on these associations are limited. In this study, we investigated the incidence of DED among patients with asthma and its correlation with other allergic comorbidities.

Methods

We retrospectively analyzed data from the National Health Insurance Research Database of Taiwan. We compared the data of 41,229 patients with asthma with those of 164,916 sex- and age-matched non-asthma controls. We followed up the patient and control groups from 1998 to 2010, and compared the rate of DED in these two groups. We further analyzed the allergic comorbidities and asthma-related medication use among the patients with asthma to verify whether these factors were associated with DED.

Results

The patients in the asthma group were more likely to have DED than were the controls (6.35% vs. 4.92%, p < 0.0001). In the asthma group, female had a higher risk of DED (odds ratio (OR) = 1.70, 95% confidence interval (CI) [1.57–1.85]) than males did. After adjustment for sex, age, income, urbanization, and the other two allergic comorbidities, patients with allergic rhinitis (adjusted OR = 1.58, 95% CI [1.46–1.72]) and urticaria (adjusted OR = 1.25, 95% CI [1.12–1.38]) were more likely to have DED, but not patients with atopic dermatitis (adjusted OR = 1.17, 95% CI [0.98–1.40]). Patients with asthma who had prescriptions of leukotriene receptor antagonists (LTRAs) (adjusted OR = 1.29, 95% CI [1.01–1.64]), oral antihistamines (adjusted OR = 2.02, 95% CI [1.84–2.21]), and inhaled corticosteroids (adjusted OR = 1.19, 95% CI [1.04–1.36]) exhibited association with DED.

Discussion

Our findings reveal that patients with asthma—particularly females—were more likely to have DED, with comorbidities such as allergic rhinitis and urticaria, and prescriptions including LTRAs, antihistamines, and inhaled corticosteroids. The results suggest that in clinical practice, physicians should pay attention to DED, particularly in patients with a high risk of DED.