bluuebunny/crossref_metadata_2025 huggingface dataset:
A COMPOSIÇÃO DO TEXTO MULTIMODAL: A RELAÇÃO ENTRE A IMAGEM E O VERBAL
Authors: Borges Sellan Aparecida Regina
Published: February 2024

Este artigo está tematizado nas formas de manifestação do racismo como possibilidades de mudança de práticas discursivas. Tem por objetivo verificar, na pratica discursiva da propaganda, se há ainda ocorrência manifesta de racismo, por conseguinte, de preconceito, mesmo em tempos em que o tema tem sido objeto de muita reflexão. Trata-se de analisar propagandas de um mesmo produto, divulgadas tempos diferentes, nos últimos anos. Toma como aporte teórico concepções da área da Semiótica social e da Análise Crítica do Discurso. Verifica-se que, de modo geral, embora os discursos tendam a modificar práticas discursivas e sociais, ainda se faz necessário empreender ações e intervenções que focalizem o racismo estrutural e o preconceito de forma mais objetiva, profunda e real.

 

Palavras -chave: Discurso. Racismo. Preconceito. Discurso da Propaganda
DIFERENTES OLHARES PARA A ANÁLISE DO DISCURSO CRÍTICA: ANÚNCIOS PUBLICITÁRIOS E TEXTOS MULTIMODAIS
Authors: Pagliuchi da Silveira Regina Célia
Published: February 2024

Este texto trata da Análise do Discurso Crítica (ADC), a partir dos múltiplos olhares de suas vertentes, com o objetivo de situar a vertente sociocognitiva e suas principais contribuições para o enfoque crítico, por ser ela a menos conhecida, no Brasil. Sendo assim, será passado um rápido olhar pelas origens da ADC, para fundamentar suas principais características e vertentes e, a título de exemplificação, uma análise crítica do machismo no Brasil, pela da intersecção de seus múltiplos olhares.

Palavras-Chave: Breve histórico, Análise Crítica do Discurso, Fundamentos, Textos multimodais
DIMENSÃO ARGUMENTATIVA POR MEIO DAS MACROPROPOSIÇÕES SEQUENCIAIS NO CONTO SOLAR DOS PRÍNCIPES, DE MARCELINO FREIRE
Authors: De Souza Moreira Eduardo , De Matos Edmar Ferreira
Published: February 2024

Este artigo tem como tema o estudo da dimensão argumentativa e das sequências textuais no conto Solar dos Príncipes, de Marcelino Freire, e tem como objetivo examinar as macroproposições sequenciais como recurso para atingir a dimensão argumentativa. Para isso, analisaremos as sequências textuais à luz da Análise Textual dos Discursos no conto freiriano, conforme proposto por Jean-Michel Adam (2011, 2019). Justificamos nossa escolha pelo texto por problematizar as condições de vivência periférica e por apresentar a maioria das macroproposições abordadas por Adam. Os resultados da análise revelam que o texto freiriano apresenta uma materialidade textual cuja estrutura composicional se dá por meio de sequências que apontam para uma dimensão argumentativa de denúncia contra a classe periférica.
O ABAIXAMENTO HARMÔNICO DE VOGAIS MÉDIAS PRETÔNICAS (NA FALA DE BELÉM/PA) À LUZ DA FONOLOGIA AUTOSSEGMENTAL
Authors: Cavalcante Xavier Francisco
Published: February 2024

RESUMO

O sistema vocálico tônico do português, com seus sete segmentos distintivos – /i, e, ε, a, ɔ, o, u/ – reduz-se a um subsistema pretônico de apenas cinco vogais – /i, e, a, o, u/. Tal redução sistêmica é fruto da neutralização do contraste de dois graus entre as médias (Câmara Jr., 1970, 1971) cuja consequência foi a queda das oposições /e/ - /ε/ e /o/ - /ɔ/, resultando em apenas um segmento anterior – /e/ – e um posterior – /o/. Não obstante, a realização fonética em dois graus das médias pretônicas não apenas persiste, mas é a materialização de importante variação dialetal no português brasileiro, com três variantes principais – a) as de manutenção: [e], [o]; b) as de abaixamento: [E], [O]; c) as de alteamento: [i], [u][1]. Para o dialeto de Belém do Pará, estudos apontam que o abaixamento é a segunda realização mais recorrente, ficando atrás apenas da manutenção das médio-altas subjacentes (Nina, 1991; Cruz, 2008 e 2013; Sousa, 2010; Fagundes, 2015; Costa, 2016; Souza, 2020). Souza (2020) investigou, especificamente, a ocorrência de harmonia vocálica no falar de Belém a partir da análise dos parâmetros acústicos da fala e concluiu que o fenômeno harmônico, de fato, guarda estreita relação com o abaixamento de vogais médias pretônicas na capital paraense. Por tratar-se de um fenômeno fonológico de assimilação, a harmonia vocálica pode ser bem explicada à luz dos pressupostos teóricos da Fonologia Autossegmental. Para esta abordagem fonológica, os traços operam de forma autônoma, podendo ser alvo de processos fonético-fonológicos, independentemente dos segmentos a que estão originalmente ligados. O objetivo central do presente trabalho é: a) apresentar e discutir os principais resultados da literatura acerca do abaixamento de /e/, /o/ pretônicas por harmonização vocálica na fala de Belém; b) demonstrar como esse abaixamento pode ser explicado e formalizado com esteio na Fonologia Autossegmental, por meio do instrumental formal da Geometria de Traços.

Palavras-chave: Vogais médias pretônicas; abaixamento por harmonização vocálica; português brasileiro; variedade belenense; fonologia autossegmental.
Phonological Structure of the Babasan Language of Serang Banten, Indonesia
Authors: Sulaeman Agus , Goziyah  , Syafri Frimadhona
Published: February 2024

This research aims to describe the Bebasan language of Serang Banten, which is related to the phonological aspect in terms of its structure, namely the vowel aspect and the consonant aspect. Regarding data acquisition, researchers collected data using the interview method to obtain data. The interview method recognizes three ways, namely: (1) asking questions, (2) direct recording, (3) recording. Researchers conducted direct interviews with informants or respondents who met the criteria and took direct notes to obtain data. In the data analysis method, the distributional or collection method is used where the researcher analyzes the data using determining tools such as the language in question. This method is usually used to analyze language speech. Meanwhile, in presenting data, formal and informal methods are used. From the results of this research, it can be concluded that in the free language of Serang, there are phonemes in each word or sentence, which can be grouped into vowels and consonants.
Faktor-Faktor yang Mempengaruhi Prestasi Olahraga Panjat Tebing Dinilai dari Sudut Pandang Pelatih dan Atlet
Authors: Risman Deffia , Damrah Damrah , Syahrastani Syahrastani , Sasmitha Weny
Published: February 2024

Permasalahan dalam peneltihan ini adalah rendahnya prestasi atlet panjat tebing Kabupaten 50 Kota. Tujuan penelitian ini adalah untuk mendeskripsikan Faktor-Faktor Yang Mempengaruhi Prestasi Olahraga  Panjat Tebing Di  Kabupaten 50 Kota.  Jenis penelitian adalah penelitian deskriptif.  Tempat penelitian federasi panjat tebing Kabupaten 50 Kota. Populasi sebanyak 17 orang, Sampel sebanyak 17 orang. Teknik pengambilan sampel menggunakan sampel Jenuh. Instrumen penelitian angket/kuesioner dan dokumentasi. Skala pengukuran dengan Skala Likert lima poin. Tingkat capaian pada faktor sarana dan pra-sarana yaitu 42,50%, memiliki klasifikasi ‘’Kurang Baik’’, Faktor Program latihan yaitu: 70,15%, dan berklasifikasi ‘’Cukup’’, Faktor Motivasi yaitu : 65,59%, berklasifikasi ‘’Cukup’’. Faktor  Mental yaitu : 54,26%, dan berklasifikasi ‘’Cukup’’. Faktor Teknik, yaitu: 61,18%, berklasifikasi ‘’Cukup’’. Faktor Kondisi fisik yaitu: 47,50%,  memiliki klasifikasi ‘’Kurang Baik’’.
Tinjauan Daya Tahan Kecepatan dan Kekuatan Para Petarung Cabang Olahraga Tarung Derajat di Kabupaten Pasaman
Authors: Khairi Zamzamil , Syahrastani Syahrastani
Published: February 2024

Tujuan dalam penelitian ini adalah untuk mengetahui tingkat daya tahan, kecepatan dan kekuatan otot lengan petarung cabang olahraga tarung derajat di di satuan latihan 01 Lubuk Sikaping, Kabupaten Pasaman. Jenis penelitian ini adalah penelitian deskriptif kuantitatif. Teknik pengambilan sampel menggunakan teknik purposive sampling, maka jumlah sampel dalam penelitian ini adalah sebanyak 18 orang petarung. Instrument yang digunakan dalam penelitian ini adalah: 1) daya tahan menggunakan bleep test, 2) kecepatan dengan lari sprint 30 meter, dan 3) kekuatan otot lengan dengan push up test. Teknik analisis data menggunakan analisis deskriptif persentatif.  Hasil penelitian ini adalah: 1) Tingkat daya tahan aerobik petarung berada pada kategori kurang. 2) Tingkat kecepatan petarung berada pada kategori kurang sekali 3) Tingkat kekuatan otot lengan petarung berada pada kategori sedang.
Survei Penerapan Literasi Visual Dalam Pembelajaran Senam Siswa Kelas VIII SMP Negeri 12 Padang
Authors: AKBARI WINDY , Handayani Sri Gusti
Published: February 2024

Pembelajaran yang terfokus pada senam merupakan sebuah perjalanan yang melibatkan pemahaman mendalam tentang berbagai teknik gerakan tubuh, koordinasi yang tepat antara otot-otot, serta pemeliharaan kesehatan secara menyeluruh, tujuan penelitian ini adalah untuk mengetahui gambaran Penerapan Literasi Visual Dalam Pembelajaran Senam Siswa Kelas VIII SMP Negeri 12 Padang, jenis penelitian ini adalah deskriptif dengan pendekatan kuantitatif, Teknik pengambilan sampel menggunakan teknik stratified proportional sampling, teknik analisis data adalah dengan analisis deskriftif kualitatif, hasil penelitian ini berdasarkan hasil analisi data Indikator Pandangan Kritis termasuk ketegori tinggi sebesar 71,03%. Pada Indikator Diskriminasi Visual termasuk ketegori tinggi sebesar 71,04%. Pada Indikator Kontruksi Makna termasuk ketegori tinggi sebesar 69,10%. Pada Indikator Penalaran Visual termasuk ketegori tinggi sebesar 66,88%. Pada Indikator Berpikir Visual termasuk ketegori tinggi sebesar 63,93%. Penerapan literasi visual dalam pembelajaran senam siswa kelas VIII SMP Negeri 12 Padang termasuk kategori timggu besaran persentase 63,93 yang mana nilai tersebut berada dalam rentang interval antara 61-80%.
Tinjauan Status Gizi Pemain Sepakbola di SMA Negeri 2 Padang Panjang
Authors: Saputra Shalli Rizki , Edwarsyah Edwarsyah
Published: February 2024

Masalah dalam penelitian ini adalah belum diketahuinya status gizi pemian sepak bola SMA Negeri 2 Padang Panjang. Penelitian ini bertujuan  untuk mengetahui status gizi pemain sepak bola SMA Negeri 2 Padang Panjang berdasarkan indeks massa tubuh (IMT). Penelitian ini merupakan penelitian deskriptif. Metode penelitian ini adalah survei dengan teknik pengumpulan data menggunakan pengukuran. Populasi pada penelitian ini adalah pemain sepak bola SMA Negeri 2 Padang Panjang yang berjumlah 16 orang. Instrumen yang digunakan untuk mengetahui status gizi adalah dengan menggunakan timbangan digital, dan alat microtoa dengan pedoman tabel gizi yang ditetapkan oleh DEPKES RI tahun 2010 berdasarkan umur. Analisis data menggunakan teknik distribusi frekuensi atau teknik persentase. Hasil penelitian menunjukkan bahwa status gizi pemain sepak bola SMA Negeri 2 Padang panjang termasuk ke dalam kategori normal dengan persentase 56,25%.
Nível socioeconômico das escolas brasileiras
Authors: Gonzaga Alves Maria Teresa , Guimarães Rodrigues Clarissa , Souza Senkevics Adriano
Published: February 2024

Este estudo apresenta a metodologia e os resultados de um indicador de nível socioeconômico (NSE) para o total de 164.840 escolas brasileiras com matrículas de escolarização, em funcionamento no ano de 2021. Foram utilizados indicadores primários, calculados com dados de questionários respondidos pelos estudantes nas avaliações e exames nacionais, e indicadores secundários - que caracterizam o contexto social das escolas, como os beneficiários do Programa Bolsa Família (PBF) -, além do NSE de estudantes transferidos entre estabelecimentos de ensino. Esses indicadores foram agregados em uma escala de NSE por meio de um modelo de respostas graduais da Teoria de Resposta ao Item. A metodologia deu visibilidade às escolas pequenas ou de áreas remotas que, até então, eram invisíveis para as políticas públicas, uma vez que elas não participam das avaliações e exames educacionais. A relação entre resultados educacionais e o NSE representa as desigualdades do País. É possível concluir que o NSE das escolas tem utilidade para a pesquisa acadêmica e potencial para contribuir com o aperfeiçoamento das políticas públicas que visam a reduzir as desigualdades educacionais.

Dados da pesquisa
Proposta metodológica de cálculo dos custos médios do Fundeb e o novo PNE
Authors: Lopes de Souza Marcelo , De Assis Alves Fabiana
Published: February 2024

Um dos desafios do novo Plano Nacional de Educação continuará sendo o seu financiamento. A definição dos objetivos a serem atingidos precisa de um planejamento quanto à previsão dos recursos e fontes de financiamento necessários para a viabilização do Plano. Nesse sentido, o estabelecimento de uma meta global de investimento público em educação pública é importante, e já mobilizou a sociedade. Contudo, deve-se, também, tratar de um conjunto amplo de diferenças e desigualdades existentes no financiamento. Este artigo trata da apuração de uma dessas diferenças: a existente entre os custos médios das várias etapas, modalidades e tipos de jornada da educação básica. Propõe-se, assim, uma metodologia para a definição dos ponderadores de custos médios do Fundeb, a principal fonte de financiamento da educação básica. Essa seria uma das formas fundamentais para melhorar o tratamento dessa questão no novo Plano. O texto discute três dimensões: as estimativas de gastos médios por subfunções educacionais, com base no Sistema de Informações sobre Orçamentos Públicos em Educação (Siope); levantamentos de custo-qualidade; e avaliação de efeitos redistributivos das alterações nos fatores de ponderação. Conclui-se que, embora o trabalho mostre convergências de estudos para correções nos atuais fatores de ponderação, o novo Plano continuará tendo o desafio de aprofundar essa questão. Contrariamente ao que se espera, algumas alterações necessárias nos ponderadores poderiam resultar em aumento das desigualdades no financiamento do sistema educacional e precisariam ser mais bem equacionadas.
Survivor Behavior in Covid-19 Prevention Efforts in Ujungbulu District, Bulukumba Regency
Authors: Amalia Iin Rezki , Azriful Azriful , Lagu Abdul Majid HR. Lagu
Published: February 2024

Background.  The increase in the number of cases infected with Covid-19 is influenced by the health behavior of survivors in preventing Covid-19. The aim of this research is to describe the knowledge, attitudes and actions of survivors towards efforts to prevent Covid-19 in Ujungbulu District, Bulukumba Regency. Methods.   This type of research is quantitative research with a descriptive approach which was carried out in March-April 2021. The sample size for this research was 186 samples. The sampling technique for this research uses simple random sampling by taking randomly until the number of research samples is met. Results.   The results of this study showed that 138 (74.1%) respondents had a good level of knowledge, 30 (16.1%) had sufficient knowledge and 18 (9.6%) had insufficient knowledge, 66 (35.4%) of respondents had a good category attitude. (59.1%) had an adequate attitude and 10 (4.8%) had a poor attitude, 58 (31.1%) of respondents had good action, 112 (60.2%) had sufficient action and 16 (8.6%) had insufficient action.  Conclusion.  To optimize respondent behavior, it is hoped that the government can provide education on the importance of complying with the 5M health protocols so that it can prevent transmission of the SARS-CoV-2 virus.
INTEGRASI PENDIDIKAN AGAMA ISLAM DALAM PENGEMBANGAN LITERASI DIGITAL UNTUK ANAK USIA DINI
Authors: Hasanah Fitria Fauziah
Published: February 2024

Literasi sangat penting untuk dikembangkan untuk anak sejak dini, karena literasi melatih kemampuan dasar anak yang dibutuhkan pada jenjang pendidikan selanjutnya. Penelitian ini mengkaji mengenai bagaimana integrasi Pendidikan agama Islam dalam pengembangan literasi digital untuk anak usia dini yang dilakukan oleh orang tua di lingkungan keluarga. Metode penelitian menggunakan metode kualitatif deskriptif dengan teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Hasil penelitian menunjukan bahwa orang tua mengembangkan literasi digital untuk anak usia dini dilakukan dengan: 1) Mengajarkan anak untuk mampu menggunakan perangkat elektronik untuk mendapatkan informasi; 2) Mengajarkan anak memahami informasi bahwa gambar, teks, cerita, dan film di perangkat elektronik memiliki makna; 3) Mengajarkan anak menggunakan perangkat elektronik untuk merekam ide, perasaan, kegiatan, atau lingkungan di sekitar mereka. Adapun pengembangan literasi digital untuk anak terintegrasi dengan Pendidikan agama Islam diantaranya dalam Pendidikan Aqidah atau ketauhidan, Pendidikan ibadah shalat, Pendidikan doa sehari-hari dan dzikir, serta Pendidikan akhlak dan berbakti kepada orang tua.

Literacy is very important to develop for children from an early age, because literacy trains children's basic abilities that are needed at the next level of education and is included in their daily lives. This research examines how the integration of Islamic religious education in the development of digital literacy for early childhood is carried out by parents in family institutions. The research method uses descriptive qualitative methods with data collection techniques using interviews, observation and documentation. The research results show that parents develop digital literacy for early childhood by: 1) Teaching children to be able to use electronic devices to obtain information; 2) Teaching children to understand information that images, texts, stories and films on electronic devices have meaning; 3) Teach children to use electronic devices to record ideas, feelings, activities or the environment around them. 4) The development of digital literacy is integrated with Islamic religious education through aspects of PAI materials and methods.
Information and Communication Technologies (ICT), Health, and Social Policy. Supporting
individuals with special needs
Authors: Ntaflou Aikaterini
Published: February 2024

The daily progress of science and the evolution of Information and Communication Technologies (ICT), constantly changes the world around us and significantly impacts the potential for improving both lifestyle and life expectancy. However, the increase in the population, especially the elderly and disabled within this population, creates a unique and demanding space for Social Policy. The need to promote tailored strategies to address these issues using ICT arises from the well-known advantages they offer. ICT
facilitates access to isolated areas with minimal or no healthcare needs, contributes to the equal provision of services, and assists and serves daily life for those who cannot independently care for their needs, ultimately contributing to achieving “health for all.” The purpose of this article is to explore trends and issues arising from such endeavours for the elderly and/or disabled members of society, as well as for focused (local) policy
considerations.
The Circular Economy: Recent debates and research trends
Authors: Džajić Uršič Erika , Fric Urška , Rončević Borut
Published: February 2024

The Circular Economy is one of the most prominent cross-disciplinary and cross-sectoral concepts to emerge in recent decades. It has permeated academia, policymaking, business, NGOs, and the general public, leading to numerous applications of the concept, some of which only partially overlap. In this article, we review recent debates and research trends in the Circular Economy, outlining the ten most common groups of its conceptualizations using the PRISMA (Preferred Items for Systematic Reviews and Meta-Analysis) method. We then propose a post disciplinary and transnational research program on the Circular Economy that would not only combine hard and soft sciences in unprecedented ways but also have important practical applications, such as developing tools to embed the Circular Economy in natural, technical, economic, and socio-cultural settings.
Advancing urban mobility in the State of Qatar—Establishing a framework for autonomous vehicles in Doha
Authors: Al-Malki Almaha , Madandola Muhammad , Thani Sarah Al , Bayram Goze , Al-Kandari Amina , Furlan Raffaello
Published: February 2024

The Government of Qatar is investing considerable resources in the development of integrated transport infrastructure as a solution to traffic congestion and environmental degradation. Autonomous vehicles are expected to be one of the methodologies for enhancing the quality of the built environment and fostering a more sustainable and environmentally conscious urban milieu. While autonomous cars have the potential to address urban difficulties and be utilized for personal, group, and public transit purposes, their implementation in the specific context of Doha has not been thoroughly analyzed. This research explores the potential impacts that autonomous vehicles are expected to have on travel demands, parking needs, and urban planning. It discusses the benefits and challenges associated with autonomous vehicles and predicts their likely implementation and development based on the different precedents. In addition, it explores how it will affect planning decisions such as drop-off and pick-up areas, parking and public transit. The research utilizes a qualitative approach through literature content analysis, field observations, and mobility analysis. Several case studies are analyzed to explore how autonomous vehicles can operate within a limited zone. The study uncovers the issue of ownership and mode of operation as essential factors that can affect the impact of autonomous vehicles (AVs). In addition, implementing AVs may create complex environmental concerns when greener and more sustainable transportation models are not integrated. It is recommended that Doha adopt integrated planning and implementation of AV technologies to ensure that AVs align harmoniously with the environmental stewardship requirement. The research study also presents urban design frameworks for how existing urban spaces can accommodate autonomous vehicles.
Dzieje kultury europejskiej i polskiej XVIII wieku w ujęciu polskich uczonych w XX stuleciu. Wybrane zagadnienia
Authors: Chachaj Marian
Published: February 2024

The article discusses the dispute over the chronology of the Enlightenment in Poland and the views of Józef Gierowski and Jacek Staszewski regarding the assessment of the Saxon times and the origins of the Polish Enlightenment. The problem of the reception of Western cultures (French, English, Italian and German) in the times of the Enlightenment in Poland was also treated more broadly. After presenting various understandings of culture in Polish historiography, the positions of Polish researchers on the assessment of the Enlightenment in Europe (Emanuel Rostworowski) and then the culture of the Saxon times and the Enlightenment in Poland (Józef Andrzej Gierowski, Janusz Maciejewski, Jacek Staszewski) were discussed. The achievements of Polish historiography in the field of research on the reception in Poland of the works of the most eminent authors of the French Enlightenment (these were primarily Voltaire, Rousseau, Diderot, Montesquieu), English (including Locke), Italian (Genovesi, Beccaria) and German (including Wolff, Gottsched) were shown in greater detail. The reception of this work would not have been possible without the appearance in Poland of an intellectual elite, often speaking French, who were able to evaluate and appreciate the innovative views of Western writers and philosophers.
Krakowskie tradycje badań nad dziejami Wysp Brytyjskich w XX i XXI wieku
Authors: Basista Jakub
Published: February 2024

The article is devoted to the presentation of the achivements of historians working in Kraków, which are devoted to the history of England, Scotland, and Ireland in the early modern period. In the inter‑war period (1918‑1939) the works of Władysław Konopczyński and Stanisław Kot are mentioned. The former authored several articles devoted to the English Parliament and English reactions to the partitions of Poland. The latter studied traces of the Polish Brethren in Britain and the consequences of their influence. After World War II it was Stanisław Grzybowski who should be named as the first historian who undertook serious research on British topics. He published a number of popular books, several of which were widely circulated and read, and one original source study on Tudor and early Stuart colonial policy. It is Grzybowski's student, Mariusz Misztal who has published the most widely on the early modern history of England, especially on Mary Stuart, James Stuart to move to 19th century topics connected with Queen Victoria. Andrzej Kuropatnicki is ‑ in turn ‑ Misztal's student. He works and publishes on early modern English cookery and medicine.
Pathways to school improvement: Discovering network patterns of school principals
Authors: Gonzales Miguel M. , Garza Tiber , Leon-Zaragoza Elizabeth
Published: February 2024

The purpose of this study is to examine the network effect of school principals as it relates to school improvement. Network practices of school principals are compared to an innovative practice for improving networking practices. Through descriptive statistics and chi-square goodness of fit, we illustrate the difference between what school principals do concerning their networking practices for school improvement compared to an innovative ideal approach for using network working for school improvement. Findings indicate there is a statistically significant difference between school principals’ networking practices in comparison to ideal networking practices for school improvement. There are also differences between who school principals seek out for ideas and who they seek out for feedback concerning their school improvements. Further discussion informs how the next generation of school principals can be equipped with innovative skills for tackling 21st-century school improvement issues.
The influence of cytotoxic drugs on the immunophenotype of blast cells in paediatric B precursor acute lymphoblastic leukaemia
Authors: Prelog Tomaz , Bucek Simon , Brozic Andreja , Peterlin Jakob , Kavcic Marko , Omerzel Masa , Markelc Bostjan , Jesenko Tanja , Prevodnik Veronika Kloboves
Published: February 2024

Background

Flow cytometry plays is important in the diagnosis of acute lymphoblastic leukaemia (ALL) and when antigen-specific immunotherapy is indicated. We have investigated the effects of prednisolone, vincristine, daunorubicin, asparaginase and methotrexate on the antigen expression on blast cells that could influence the planning of antigen-specific therapy as well as risk-based treatment assignment.

Patients and methods

Patients aged ≤ 17 years with de novo B-cell ALL (B-ALL) were enrolled in the study. Blast cells were isolated and exposed in vitro to 5 individual cytotoxic drugs in logarithmically increasing concentrations. Then, the expression of CD10, CD19, CD20, CD27, CD34, CD45, CD58, CD66c and CD137 antigens was determined by quantitative flow cytometry.

Results

Cytotoxic drugs caused dose-dependent or dose-independent modulation of antigen expression. Daunorubicin caused a dose-dependent down-modulation of CD10, CD19, CD34, CD45 and CD58 and an up-modulation of CD137. Vincristine caused a dose-dependent down-modulation of CD19 and CD58 and an up-modulation of CD45. Daunorubicin also caused dose-independent down-modulation of CD27 and prednisolone down-modulation of CD10, CD19, CD27, CD34 and CD58. Down-modulation of CD20 was detected only in relation to the specific dose of daunorubicin.

Conclusions

The results of the study have shown that cytotoxic drugs can alter the expression of antigens that are important for immunotherapy. Importantly, daunorubicin, prednisolone and vincristine caused down-modulation of CD19 and CD58, suggesting that these drugs are better avoided during bridging therapy prior to bispecific antibodies or CAR-T cell therapy. In addition, immunophenotypic changes on blast cells induced by different drugs could also influence risk-based treatment assignment.
The prognostic significance of programmed cell death protein 1 and its ligand on lymphoma cells and tumor-immune cells in diffuse large B-cell lymphoma, not otherwise specified
Authors: Slak Teja Cas , Miceska Simona , Gasljevic Gorana , Boltezar Lucka , Kloboves-Prevodnik Veronika
Published: February 2024

Background

Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) is the most common type non-Hodgkin’s lymphoma, where the treatment of relapsed/refractory cases is the major challenge. Programmed cell death protein 1 (PD-1) and its ligand PD-L1 play a crucial role in the negative regulation of the immune response against the disease. The aim of the study was to analyze the expression of PD-1 and PD-L1 on lymphoma cells (LCs) and tumor-immune cells (TICs) and to investigate their correlation with outcome.

Patients and methods

Samples from 283 patients diagnosed with DLBCL, NOS (both germinal center B cell like [GCB] and non-GCB subtypes) were included in the study. Expression of PD-1 and PD-L1 was determined using double immunohistochemical staining (D-IHC) for PD-1/PAX5 and PD-L1/PAX5 on tissue microarrays. LCs were highlighted by D-IHC to obtain more accurate results. Clinical data and histologic diagnoses were obtained from electronic data records. We correlated clinical characteristics, and PD-1 and PD-L1 expression on LCs and TICs with progression-free survival (PFS) and overall survival (OS).

Results

Expression of PD-1 on TICs was observed in 38.4% and on LCs in 8.8% of cases, while PD-L1 was expressed on TICs in 46.8% and on LCs in 6.5% of cases. PD-L1 expression on LCs was more frequent in non-GCB subtype (p = 0.047). In addition, patients with PD-L1 expression on LCs had significantly shorter PFS (p = 0.015), and the expression retained significant in the multivariate model (p = 0.034).

Conclusions

PD-L1 was more frequently expressed in LCs of the non-GCB subtype. Additionally, PD-L1 in LCs may predict shorter PFS time. D-IHC staining for PD-L1/PAX5 is a feasible method to assess PD-L1 expression on LCs of DLBCL, NOS patients and can be used to identify patients who may benefit from targeted immunotherapy with checkpoint inhibitors.
Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma
Authors: Ramanovic Manuel , Novak Marko , Perhavec Andraz , Jordan Taja , Popuri Karteek , Kozjek Nada Rotovnik
Published: February 2024

Background

Retroperitoneal sarcomas (RPS) are rare tumours of mesenchymal origin, commonly presented as a large tumour mass at time of diagnosis. We investigated the impact of body composition on outcome in patients operated on for primary localized RPS.

Patients and methods

We retrospectively analysed data for all patients operated on for primary RPS at our institution between 1999 and 2020. Preoperative skeletal muscle area (SMA), visceral and subcutaneous adipose tissue area (VAT and SAT) and muscle radiation attenuation (MRA) were calculated using computed tomography scans at the level of third lumbar vertebra. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were applied to define myopenia. Using maximum log-rank statistic method we determined the optimal cut-off values of body composition parameters. Myosteatosis was defined based on determined MRA cut-offs.

Results

In total 58 patient were eligible for the study. With a median follow-up of 116 months, the estimated 5-year overall survival (OS) and local-recurrence free survival (LRFS) were 66.8% and 77.6%, respectively. Patients with myopenia had significantly lower 5-year OS compared to non-myopenic (p = 0.009). Skeletal muscle index and subcutaneous adipose tissue index predicted LRFS on univariate analysis (p = 0.052 and p = 0.039, respectively). In multivariate analysis high visceral-to-subcutaneous adipose tissue area ratio (VSR) independently predicted higher postoperative complication rate (89.2% vs. 10.8%, p = 0.008). Myosteatosis was associated with higher postoperative morbidity.

Conclusions

Myopenia affected survival, but not postoperative outcome in RPS. Visceral obesity, VSR (> 0.26) and myosteatosis were associated with higher postoperative morbidity. VSR was better prognostic factor than VAT in RPS.
Digital twins in the information space as a reflection of a person
Authors: Baranov L. I.
Published: February 2024

The article considers the phenomenon of the influence of information and communication technologies on human life and the growth of the scale of this influence in the modern era, characterized by the ubiquity of the Internet. The research proves that the growth in the number of Internet users, intensification of human immersion in the network, improvement of Internet technologies, have led to significant changes in social life. The development of electronic services and provision of roundthe-clock access to them have led to a significant increase in online sales of almost all types of everyday goods. In addition, the continuous improvement of electronic devices with a wide range of opportunities for users has led to a qualitative development of the infrastructure of interaction with the Internet. Under these conditions, the information space forms conditions and opportunities for the creation and preservation of digital doubles of a human, partially or fully reflecting his or her physical and personal characteristics. As technologies develop, these digital doubles can become more independent and closer to their originals not only in the information space, but also in the physical world. In this regard, the author notes the threats of such development and argues for the need to carefully analyze the possible consequences of the widespread use of digital doubles in order to ensure that their development is for the benefit of human beings.
Export and import statistics on e-commerce in computer services: classification and evaluation challenges
Authors: Zhivykh M. V.
Published: February 2024

The specific domain of e-commerce within computer services has been insufficiently explored as a distinct area of scholarly inquiry. It is typically subsumed under the broader umbrella of ICT services, a classification that complicates accurate statistical market assessments. Present static accounting methodologies provide only a roundabout means for estimating the scope of international trade activities within the computer service sector. This study engages in a comprehensive analysis of the nuances involved in accounting for the export and import of computer services. It examines the global practices of data gathering for statistical purposes, confronts classification dilemmas, and addresses the complexities of identifying the service delivery location and mode. The culmination of this analysis is a set of proposed enhancements to statistical accounting methods. For the sake of international comparisons, it is advisable to equate the cross-border e-commerce of computer services with the exportation of services through the first mode of cross-border supply, which constitutes approximately 75% of all exported computer services. The adoption of more granular tracking methodologies for cross-border transactions necessitates the creation of a standardized ontology at the international level. The urgency of establishing a definitive conceptual framework and performing a thorough market analysis for e-commerce is underscored by the need to fine-tune policy support measures, evaluate the export potential of emerging markets, propose exemptions for e-commerce from traditional trade regulations, implement fair taxation policies, avert discrimination in determining the tax base, promote statistical coherence, and sustain a consistent stance during international negotiations and disputes resolution.
Knowledge, Skills and Attitudes Required by Students to Apply Good Practice Based on Evidence
Authors: Gomes Shawana Meita Souza , Diniz Yan Carlos de Sousa , Batista Carolina Pedrosa , De Lima Lucas Lucena , De Pontes Filho Rui Nóbrega , Nogueira Tiago Bezerra de Sá de Sousa , Nogueira Raquel Bezerra de Sá de Sousa , De Sousa Milena Nunes Alves
Published: February 2024

Objective: to identify the Knowledge, Skills and Attitudes necessary for an Evidence-Based Practice of Excellence.
 
 Method: This research was conducted following the principles of an integrative literature review. Data collection was carried out based on the selection of scientific articles published on the platforms of the Virtual Health Library and the National Library of Medicine and the National Institutes Health, including full text articles, in Portuguese, English and Spanish, being published in the last 10 years, the Health Sciences Descriptors "Evidence-Based Practice" being “students” and “health”, which were crossed with the Boolean operator AND. Finally, I selected 15 surveys.
 
Results/Discussion: The majority of studies presented were produced in 2021 (33%; n = 5) and the language was predominantly English (73%; n = 11). Furthermore, competencies are agreed, namely knowledge, skills and attitudes involved in the EBP development process. The main knowledge is mastering the stages of scientific investigation, critically interpreting literature, basic use of information technology and applying the knowledge acquired in cases individual. When referring to skills, it is necessary to take into cultural consideration the environment in which this practice is being carried out, in addition to the ability to communicate in other languages and computer skills. The most important attitudes include the student's particular interest in participating and improving in the scientific field, in addition to applying evidence.
 
Conclusion: The identification of the skills necessary to apply EBP is necessary to guarantee a solid foundation before carrying out such practice in the community, which will guarantee better health for the population in the long term, in addition to promoting technical and practical improvement for students and professionals who produce them.
Penyusunan Program Komputasi Pengidentifikasi Parameter Dinamik Balok Ditumpu Jepit-Bebas
Authors: Bur Mulyadi , Hadiguna Rika Ampuh
Published: February 2024

Operational Modal Analysis (OMA) is a new procedure to identify a structural vibrating system. In this paper, the operational modal analysis based on Ibrahim Time Domain Method. This method requires some displacement data from free vibration response of structure model. Here, a beam with clamped-free condition is used as a test model. Based on Finite Element Method, this beam is divided into 3 elements that consist of 6 degree of freedoms for each element (3 translations and 3 rotations). In this case, a fixed lumped mass is added to each translation node. The beam is excited in its clamped support by sinusoidal displacement during 0.1 s. After 0.1 s, the excitation is stopped and then the displacement data is recorded. Therefore, this condition could be assumed that recorded data represents free vibration response. For this purpose, some computation program was developed to predict the response of free vibration system. First, we make a program SINUS.FOR to produce a sinus displacement function. This function as a support motion is used as an input for program BALKEN.FOR that consist of various program, like Guyan Condensation, Cholesky Decomposition, Jacobi Method, Matrix Iteration Method, Phase Plane Method, Finite Difference Method, Houbolt Method, etc. This entire program is compiled by FORTRAN programming language. Next, the output of BALKEN.FOR that called matrix [A] become an input of program EIGENWERT-ITD.MW which is written in MAPLE programming languages. In this research, it is assumed that only the displacement of x1(t), x2(t) and x3(t) is known. It is known that to identify a system with 6 degrees of freedom, The Ibrahim Time Domain Method requires  displacement responses. To fulfill this condition, we need 9 pseudo measurement stations. It means that each station with known displacement response has to be manipulated in such way so that it can produce 3 pseudo displacement response groups. The Result shows that the common error is below 5 %. Except, the damping ratio of mode number 5 is more than 10 %. While the other result can be identified better, especially for the natural frequency is identified very well.
Penerapan Metoda High Pressure Jet Cooling (HPJC) untuk Mengurangi Keausan Tepi Pahat pada Proses Membubut dengan Kecepatan Rendah
Authors: Mulyadi Ismet Hari
Published: February 2024

High Pressure Jet Cooling (HPJC) is an alternative method to the ineffective and environmentally friendly flooding method for coolant distribution at the cutting contact area. This method is widely utilized in the machining process of materials that are difficult to cut or have superior mechanical properties using various tools that have high cutting speeds. At high cutting speeds, it will be difficult for coolant to penetrate the contact area. For this reason, in this study HPJC is used to turn low carbon steel material with a tool that has a low cutting speed. By using a tool capable of providing pressure variation in coolant delivery, flank wear as a result of the turning process was observed. The results were validated using ANOVA and Fisher Least Significant Differences methods. The results show that pressure variation can reduce the tool wear rate. However, the tools used were not sufficient to distinguish the change in applied pressure from the reduction in tool life. This is because the coolant is only concentrated on the main plane of the tool. As a result, other types of wear, namely nose wear, have increased.
PENGARUH FINANCIAL DISTRESS DAN CAPITAL INTENSITY TERHADAP TAX AVOIDANCE DENGAN UKURAN PERUSAHAAN SEBAGAI PEMODERASI
Authors: Julianty Indira , Agung Ulupui I Gusti Ketut , Nasution Hafifah
Published: February 2024

The decline in tax performance during the Covid-19 pandemic is the reason for conducting this study, namely to find out whether tax avoidance activities are increasingly being carried out, especially in the consumer non-cyclicals and consumer cyclicals sectors during the 2020-2022 period. This study is also intended to confirm the inconsistency in the relationship between financial distress and capital intensity on tax avoidance by presenting moderating variables in the form of firm size as a novelty from previous research. Using the absolute difference value test, this study shows that financial distress has a negative effect on tax avoidance, while capital intensity and firm size do not affect tax avoidance. In addition, the effect of financial distress and capital intensity on tax avoidance cannot be moderated by firm size. The implications of this study indicate the need for increased supervision from the government and shareholders on management to avoid tax avoidance, especially in companies that are financially healthy.
ECOSSISTEMAS DE INOVAÇÃO EM FOCO: UMA REVISÃO INTEGRATIVA
Authors: Cordula Dos Santos Lucia , Rebouças Porto Júnior Francisco Gilson , Pontes-Silva André , Sallazar Ferreira Pereira Renan , Sinésio Neto Luiz , Santos Figueiredo Francisco Winter dos , Rodrigues Peixoto Quaresma Fernando
Published: February 2024

artigo buscou identificar na literatura a situação dos ecossistemas de inovação que estimulam empreendedores e estudantes a transformarem ideias em produtos e serviços de saúde. Método: Revisão integrativa, com busca nas bases de dados Virtual Health Library (VHL/BVS), MEDLINE/PubMed (National Library of Medicine National Institutes of Health), Web of Science (WOS), Scopus e a coletânea da biblioteca virtual Scientific Electronic Library Online (SciELO), utilizando os descritores controlados Health Personnel, Hospitals, Program Evaluation, Occupational Health Services, Accident Prevention, Needlestick Injuries, Needles, Accident Prevention, Prevention and control, Accidents, Occupational. Trata da análise das estratégias e processos de gestão utilizados em ecossistemas de inovações, universitários ou não, mas que resultaram em soluções inovadoras para questões relevantes ao universo em que estavam compreendidos. Foram analisados 11 artigos que relatam experimentos de sucesso realizados na Europa Central, África, América e Ásia. Resultados:  encontrados servirão como referência para a análise de como é tratado o empreendedorismo e o empreendedorismo universitário nestas regiões e como ele atua no fomento a inovações que implementem processos de cuidados à saúde. Conclusão: Os estudos apontam a inovação aberta como uma das principais formas de se alcançar inovações disruptivas no segmento da saúde, entretanto há riscos empresariais envolvidos. Universidades e governos têm papel estratégico neste desenvolvimento, seja através de um currículo inovador, ou na continuidade de programas governamentais de incentivo a empreendedores e pesquisadores.
Energy Efficient Localization Technique Using Multilateration for Reduction of Spatially and Temporally Correlated Data in RFID System
Authors: Dash Lucy , Pattanayak Binod Kumar , Laha Suprava Ranjan , Pattnaik Saumendra , Mohanty Bibhuprasad , Habboush Ahmad Khader , Al Smadi Takialddin
Published: February 2024

RFID plays a vital role in data communication in multidimensional WSNs as it collects vast amounts of redundant data. The physical phenomena constitute the correlated observations in the space domain and generate spatial correlation. Periodic observations of sensor nodes result in a temporal correlation in the data. Reducing these spatio-temporal correlations in RFID surveillance data is necessary for the smooth functioning of the network. This paper proposes a Voronoi diagram-based spatio-temporal data redundancy elimination approach for RFID systems having multiple readers so only one reader will read every RFID tag depending on the distance between the tag and the center of the Minimum Enclosing Circle of the Voronoi cell to which the reader belongs. This approach eliminates spatial redundancy in the gathered data. Reading the RFID tags at regular time intervals larger than a chosen threshold value minimized temporal redundancy. In contrast to existing methods, the proposed technique is free from any false positive and false negative errors, with no loss of data and every tag being read by only one reader. Simulation of the proposed approach also established its superiority to the existing techniques in terms of these performance parameters.
You Are (Not) Your Brain: Incompatible Images of Human Beings in The Neurosciences
Authors: Craffert Pieter
Published: February 2024

On an unprecedented scale, contemporary neuroscience confronts us with claims about our essential nature as human beings. These vary from you are your brain to you have no free will. Despite the prevalence of these claims in the neurosciences on the big questions about ourselves, contemporary neuroscience of consciousness does not speak with a unified voice. Although mainstream neuroscience of consciousness claims that you are your brain, a minority tradition argues you are not your brain but that you have a brain. The substance of these two traditions is presented in this article. An evaluation of the impact of the neurosciences on the big questions of being humans should as a first step appreciate the significance that the neurosciences do not automatically provide a solution to these age-old questions about human beings but display a spectrum of views.