bluuebunny/crossref_metadata_2025 huggingface dataset:
Lateral Meniscal Graft Transplantation: Effect of Fixation Method on Joint Contact Mechanics During Simulated Gait
Authors: Brial Caroline , McCarthy Moira , Adebayo Olufunmilayo , Wang Hongsheng , Chen Tony , Warren Russell , Maher Suzanne
Published: July 2019

Background:

Controversy exists regarding the optimal bony fixation technique for lateral meniscal allografts.

Purpose/Hypothesis:

The objective was to quantify knee joint contact mechanics across the lateral plateau for keyhole and bone plug meniscal allograft transplant fixation techniques throughout simulated gait. It was hypothesized that both methods of fixation would improve contact mechanics relative to the meniscectomized condition, while keyhole fixation would restore the distribution of contact stress closer to that of the intact knee.

Study Design:

Controlled laboratory study.

Methods:

Six human cadaveric knees were mounted on a multidirectional dynamic simulator and subjected to the following conditions: (1) native intact meniscus, (2) keyhole fixation of the native meniscus, (3) bone plug fixation of the native meniscus, and (4) meniscectomy. Contact area, peak contact stress, and the distribution of stress across the tibial plateau were computed at 14% and 45% of the gait cycle, at which axial forces are at their highest. Translation of the weighted center of contact stress throughout simulated gait was computed.

Results:

Both bony fixation techniques improved contact mechanics relative to the meniscectomized condition. The keyhole technique was not significantly different from the intact condition for the following metrics: contact area, peak contact stress, distribution of force between the meniscal footprint and cartilage-to-cartilage contact, and the position of the weighted center of contact. In contrast, bone plug fixation resulted in a significant decrease of 21% to 28% in contact area at 14% and 45% of the simulated gait cycle, a significant increase in peak contact stresses of 34% at 45% of the gait cycle, and a shift in the weighted center of contact, which increased forces in the cartilage-to-cartilage contact area at 45% of the gait cycle.

Conclusion:

While both keyhole and bone plug fixation methods improved lateral compartment contact mechanics relative to the meniscectomized knee, keyhole fixation restored contact mechanics closer to that of the intact knee.

Clinical Relevance:

Method of meniscal fixation is under the direct control of the surgeon. From a biomechanics perspective, keyhole fixation is advocated for its ability to mimic intact knee joint contact mechanics.
Transrectal ultrasound in abacterial chronic prostatitis: Identification of a possible reference pattern
Authors: Conti G. , Gianneo E. , Fumagalli L. , Sala E. , Antinozzi R. , Comeri G.C.
Published: July 2019

Chronic prostatitis caused by sexually transmitted pathogens (Chlamydia Trachomatis, Ureaplasma Urealyticum, Mycoplasma Hominis) is a quite frequent disease in the mean age of life (20–50 years). Diagnostic difficulties are encountered because of poor symptomatology and inadequacy of common laboratory microbiologic essay. So this disease requires a rather elaborate diagnostic procedure like specific determination of microrganisms in seminal fluid, prostatic and urethral secretion. From the echographic point of view no patognomonic patterns can be referred to at present. The authors identified in a group of 48 patients with proven infection by sexually transmitted pathogens, some echographic findings perhaps indicative of this prostatic disease (more evidence of cranial periurethral prostatic hypoechogenicity in all infected patients, and quite complete resolution in a high percentage of patients after microrganism eradication). If confirmed by a higher number of observations, this data may become a useful diagnostic instrument in the approach to sexually transmitted prostatic disease in order to support and confirm the diagnosis and therapy.
Determination of the serum anti-bodies (TB-Test) in the diagnosis of urogenital tubercolosis: Preliminary note
Authors: Fontana D. , Porpiglia F. , Toffola A. Della , Chirillo G. , Scoffone G. , Tarabuzzi R. , Del Noce G.
Published: July 2019

The Authors report the results concerning the serological test (TB-test) used for diagnosing tubercolosis. They compare three groups of patients: the first group is represented by 19 patients suffering from urogenital tubercolosis; the second group is represented by 9 patients having preexistant lung tubercolosis and now healed; the third group is represented by 12 healthy patients. The TB-test values among the three groups are compared with statistical tests (χ-square and t-test). It is demonstrated that there is a statistical significant difference between the values obtained among the first group and the third one. No statistical significant difference is demonstrated between the second and the third group. The Authors conclude that, although tubercolosis diagnosis is of the cultural type, TB-test may have a certain utility in diagnostic methods.
Blended anesthesia in major urological surgery
Authors: Preciso G. , Spinella F. , Spimpolo A.M. , Gasparella V. , Bastianello P. , Seren P. , Benzone S. , Artuso G.
Published: July 2019

The Authors report the results of a retrospective analysis of two groups of patients, who underwent major urological surgery, (extensive nephrectomies, radical prostatectomies, retroperitoneal lymphadenectomies and radical cystectomies with urinary diversion according to Bricker, VIP, US).

Improvementiv surgery and clinical results is largely due to the improvement of the combined anaesthesiologic action — a light general and at the same time selective peridural anaesthesia — considering that both groups of patients were treated equally, in that they were nourished in the same way in the pre and post-operative phases and underwent the same intensive cures immediately after the operation, which was invasive and aggressive.
Intraoperative autotransfusion during radical prostatectomy
Authors: Dell'Acqua S. , Tombolini P. , Ruoppolo M. , Bellorofonte C. , Zaatar C. , Ferri P.M. , Yamak R. , Tagliaferri A. , Innocenti L. , Beleggia F.
Published: July 2019

Intraoperative autotransfusion is the ideal method for restoring blood loss during surgical procedures. In the last few years the confirmation of damage due to transfusion of stored blood, plus risingcosts, led to a revaluation of this procedure. From March 1990 to December 1991, 18 patients underwent intraoperative autotransfusion during radical prostatectomy for carcinoma stage B, utilizing a Dideco Autotrans BT 795 processor. Recovered blood was washed by physiological solution, centrifuged and filtered for air bubble and aggregate elimination, then reinfused. Average recovered blood rate was 853 ml (640-1087), the retransfused rate was 557 ml (410-727). Preoperative Ht rate was between 38.6% and 42.7% (average 40.8%); in the immediate post operative period (4–6 hours after procedure) Ht rate was between 34.3% and 38.6% (average 36.8%). No stored blood was required. We propose a wider utilization of this procedure for safety and lower cost.
Two years experience in computer filing of ESWL treatments
Authors: Bianchi G. , Curti P. , Schiavone D. , Cavalleri S. , Comunale L. , Mobilio G.
Published: July 2019

ESWL treatment filing system by computer has proved itself to be very useful; however both the structure of the files and the programming procedure required several changes in order to allow accurate analysis of the results of this treatment. Such changes allow evaluation of the results related to both the patients globally and the single stones specifically.
Methotrexate and estramustine phosphate in the treatment of hormone-refractory prostatic carcinoma. Preliminary study
Authors: Torelli T. , Bacchioni A.M. , Corrada P. , Leidi G.L. , Ordesi G. , Zanitzer L. , Campo B.
Published: July 2019

The authors report preliminary results of a study performed on six patients with by advanced, hormone-refractory prostate cancer. These patients were treated by estramustine phosphate (10 mg/kg) and methotrexate (60 mg/mq). Low toxicity allows the use of this therapy in outpatient regimens. Moreover, the high rate of partial responses (five patients) shows the remarkable efficacy of this therapy, even if follow-up and number of patients are not sufficient to reach definitive conclusions.
Adjuvant immunotheraphy in the treatment of superficial multicentric bladder tumors
Authors: Lissoni G. , Galbiati G. , Borin R. , Ferruti M. , Milani C.
Published: July 2019

The authors report their results in adjuvant immunotherapy with B.C.G. after TUR for superficial and multicentric bladder tumors (Ta-T1). After TURB a cycle of intravesical immunotheraphy with 150 mg of BCG (Bacillus Calmette-Guerin) is performed once a week for 6 weeks, ther every 2 weeks for 6 times and finally once a month for 1 year. (16.5 months of treatment). Controls with CTM and cystoscopy are performed periodically. 63 patients have been treated: 20 (60.6%) are free from disease with follow-up of 18–36 months; 87.5% of patients who had BCG as immunotherapy after first TUR for bladder tumor, are free from disease. Comparing their results with experiences reported in literature with Mytomicin and Doxorubicin, the authors think that adjuvant immunotherapy with BCG is actually the best local treatment for these tumors. Some patients (25%) had slight troubles because of therapy but only in 3 cases (9.09%) treatment was stopped. In conclusion intravesical therapy with BCG significantly changes natural history of superficial bladder tumor, increasing the time free from disease (in our experience: 27 months).
Staghorn renal calculi: Personal experience with PCN
Authors: Zucconelli R. , Belmonte P. , Francini M. , Fiaccavento G.
Published: July 2019

We report the results on 47 patients treated for staghorn renal calculi (partial and complete) by PCN-monotherapy and PCN-debulking. According to Rocco's classification the renal stones were 34 C4 and 13 C5. The PCN-monotherapy was used for 34 C4 and 6 C5, and showed itself to be resolutive in 83.4%. We resorted to the PCN-debulking in 7 cases, all C5: subsequent treatment with Extracorporeal Shock Wave Lithotripsy (ESWL) was performed or planned in other Centres. We emphasize the feasibility of PCN in staghorn renal calculi for the low incidence of major complications and for sometimes reducing the wait, both before and after treatment of complex renal lithiasis.
Instrumental chemiolysis as sole treatment for urinary stones
Authors: Minervini M.S. , Malagola G. , Dormia G. , Luongo P. , Bertana F. , Castellani R. , Gonnella G. , Mantovani F. , Mazza L.
Published: July 2019

Until the eighties chemiolysis represented the only alternative to surgery in the treatment of reno-ureteral stones. Nowadays it successfully used as debulking pre ESWL or to eliminate residual or ureteral fragments, even after unsuccessful percutaneous or ureteroscopic treatments. We report our experience on instrumental chemiolysis as elective procedure in selected patients.
Laparoscopic varicocelectomy: Preliminary study
Authors: Tombolini P. , Ruoppolo M. , Bellorofonte C. , Beleggia F. , Zaatar C.
Published: July 2019

Varicocele is frequently a contributing factor in male infertility. We performed outpatient laparoscopic varicocelectomy in 13 patients (15 varices) with clinically evident varicocele and persistent oligo-asthenospermia. Identification and preservation of the spermatic artery was easy in all cases. Mean interval to resumption of preoperative activity levels was 3 days. The procedure decreases post-operative morbidity.
Preliminary report on laparoscopic treatment of renal cysts
Authors: Tombolini P. , Novellino L. , Ruoppolo M. , Bellorofonte C. , Beleggia F. , Zaatar C. , Gozo M. , Ferri P.M.
Published: July 2019

Renal cysts are frequently recognised by urological assessment. The management of these cysts is performed by echoguided percutaneous puncture and drainage, by sclerosing with alcohol or antimitotic agents or by open surgery. Laparoscopy is a safe and reliable procedure for treatment of cryptorchid testicle, varix ligation and staging of lymph nodes in prostatic cancer. From 2/92 to 3/93, we treated in our center, 4 patients with renal cysts. The patients were placed in a contro-lateral position. The Verress needle is inserted at the edge of the rectus muscle. The first Trocar is placed 5 cm above the needle. The following trocars are placed in the hemiabdomen related to the cyst. The cyst was freed and resected. In 3 cases the procedure was successful. In the last one, laparoscopy failed because of damage to the speen. The patients were mobilized within 1 day and discharged within 3 days.
Echinococcosis of the psoas muscle: Clinical case
Authors: Blefari F. , Risi O. , Pino P.
Published: July 2019

A rare case of hydatid cyst of the left psoas muscle with a short account of the nosological, physiopathological and therapeutical aspects due to muscular echinococcosis is reported. The Authors particularly emphasize the diagnostic difficulties due to discrepancies between radiological imaging and serological data and specially recommend prudence in surgical management.
Para-urethral vaginal leiomyoma
Authors: Giunta A. , Silvestre P. , Xausa D. , Gherardi L. , Tamia A. , Breda G. , Guerini A. , Venza E.
Published: July 2019

Only a few cases of para-urethral vaginal leiomyoma have been reported in literature. We describe two additional cases and discuss the differential diagnosis and management.
Endoscopic correction of vesicoureteral reflux in the adult by Teflon injection
Authors: Da Pozzo G.P. , Simeone C. , Cozzoli A. , Zambolin T. , De Luca V. , Scanzi M. , Cunico S. Cosciani
Published: July 2019

Appropriate therapy of vesicoureteral reflux is a controversial topic. Many studies have been performed to compare medical versus surgical treatment and various operations have been described to correct vesicoureteral reflux. In recent years, endoscopic subureteral Teflon Injection has been used successfully, mostly in children. We report our positive experience in 31 adults. The procedure proved to be simple and reliable. No complications have occurred.
Complications in radical cystectomy and their prevention
Authors: Pavone-Macaluso M. , Montie J. , Serretta V. , Tazaki H. , Bono A. , Bocconc-Gibod L. , Miyanaga N. , Albrecht W. , Karthaus P. , Melloni D. , Pavone C. , Pisciotta A.
Published: July 2019

We wish to dedicate this review article on radical cystectomy, its complications and their prevention to the memory of Prof. Luciano Giuliani. The article is based on a work written originally by Jim Montie and many other authors for the consensus meeting on bladder cancer held in Antwerp in 1994 and recently published in a booklet entitled “Global strategy for bladder cancer” (1). With the consent of Montie and the other co-authors, we have prepared on updated Italian version, inserting some parts (such as vascular complications) which were treated more superficially in the preliminary text.
Quail sono i limiti attuali dell'indicazione alla prostatectomia radicale?
Authors: Zappalà L. , Bertè R. , Callari S. , Guaitoi P. , Mazza G.
Published: July 2019

Progressive improvement in surgical techniques has considerably reduced complications subsequent to radical prostatectomy, which has been considered first choice treatment for about a decade. At the same time two lines of thought have been established regarding the more or less extended indication for surgery. Today's greater knowledge concerning the biological behaviour of the neoplasm and the significance of the prognostic factors should stimulate reflection about the selection of patients for more effective surgery.
La progressione di malattia dopo prostatectomia radicale: Quale strategia terapeutica?
Authors: Bertè R. , Guaitoli P. , Callari S. , Zappalà L. , Mazza G.
Published: July 2019

Cancer progression, following radical prostatectomy, is distinguished by its biological or clinical aspects and is a controversial subject. As adjuvant therapy there is hormonal treatment and radiation therapy or a combination of both. The lack of standardization of the main pathological features of prostate cancer does not allow an accurate valuation of the results from the most important studies. A real efficacy in local or distant control seems to be certain, while the influence on disease-free survival is more uncertain. After a review of the most common options of treatment, the Authors present their results from 107 radical prostatectomies carried out between 1989 and 1994.
Laserterapia della IPB
Authors: Marco G. Dl , Corvaja A.
Published: July 2019

TURP is performed in 80% of cases of benign prostatic hypertrophy (BPH), but one of the alternative methods, which uses the photocoagulating energy of the laser beam and in particular the Nd-Yag, seems to be very promising. Used in prostates with a suitable weight (< 40 g) and in particular in high-risk patients with myocardiopathies and/or coagulative troubles, this source of energy, through fibres at right angles or in contact or interstitial, permits the photocoagulation or vaporisation of the prostatic tissue. Association of this technique with the usual TURP has been suggested in heavier prostates, for a quick return to spontaneous micturition. The absence of bleeding, retrograde ejaculation and more serious complications, plus the reduced time of hospitalisation make this a safe technique in selected cases.
Chemioterapia endovescicale antiblastica con idarubicina. Risultati preliminari
Authors: Messina G. , Serretta V. , Piazza S. , Gange E. , Falletta V. , Piazza B.
Published: July 2019

Preliminary results are given of the topical endovesical use of idarubicin for superficial bladder urotheliomas. Its toxicity toward the urothelium is underlined; a fact which strongly compromises its endovesical chemotherapeutic use.
Terapia della calcolosi delle vie urinarie: Ancora tema controverso? Interrogativi
Authors: Orestano F. , Giardina M. Curti
Published: July 2019

The authors report some cases of urinary calculosis mistakenly treated in monotherapy with ESWL. They indicate the limits of this technique as well as the necessity of starting auxiliary and/or alternative methods. In the authors’ opinion the indispensable preliminary parameter is the careful evaluation of the functional possibilities of the involved area, also taking into account that if anatomical function is partially or totally compromised, traditional surgery undoubtedly still plays a leading role.
Studio urodinamico della contrattilità detrusoriale e del vuotamento vescicale femminile
Authors: Pennisi M. , Leanza F. Grasso , Pepe P. , Panella P.
Published: July 2019

Computerised urodynamic analysis is extremely interesting when studying detrusorial contractility in the woman. The authors give the results of urodynamic exams Performed on 150 women, in which the contractile power, the contraction speed, the force, the energy, the detrusorial work and the URA (urethral flow resistance factor) are considered in addition to the standard pressure and flowmetry parameters.
Surgical and endoscopic treatment of ureterocele: Case reports
Authors: Trombetta C. , Savoca G. , Poddighe S. , Salisci E. , Siracusano S. , Raber M. , Belgrano E.
Published: July 2019

— Ureterocele is a cystic dilatation of the ureter, often associated with urinary tract infection and vesico-ureteral reflux. Treatment should aim at preserving renal function. Eight patients with ureterocele were included in this study. Three of them underwent surgery hemiureteronephrectomy with ureterocystoneostomy was performed in two, while a supernumerary blind-ending ureter in the third was resected and the complementary ureter reimplanted. Endoscopic incision of the ureterocele was carried out in five patients, of whom four were children. Endoscopic incision was possible in all patients and hospital stay was considerably shortened. In two cases endoscopic incision was followed by UCNS of both ureters Our results agree with data reported in recent literature (93% successful endoscopic procedures).
Correction of vesicoureteral reflux in kidney transplanted patients by submucosal Teflon injection
Authors: Guermani P. , Alladio F. , Arena G. , Manzo M. , Ferrando U. , De Natale A. , Cucchiarale G.
Published: July 2019

— The Authors evaluate the efficiency of submucosal Teflon injections for the treatment of vesicoureteral reflux in kidney transplanted patients. They suggest the use of Teflon both for resolving urinary tract infections and for the final correction of the vesicoureteral reflux.
Urological surgery in patients with a prosthetic heart valve. Experience in 59 cases
Authors: Fandella A. , Merlo F. , Maccatrozzo L. , Faggiano G. , Anselmo G.
Published: July 2019

— Patients with prosthetic heart valves must be kept free from blood clots due to the high thromboembolic risk. Whenever these patients need to be operated, inadequate control of coagulation may lead to a high risk of haemorrhage or thrombosis. From January 1990 to December 1994, 59 patients with prosthetic heart valves undergoing chronic therapy with oral anticoagulants were treated in our Unit. Until December 1993 patients were treated with calcium heparine s.c., suspending the oral anticoagulant; this group showed a high risk of haemorrhage even with normal PTT values. In fact 19% of patients required blood transfusions while 8% had to be treated for haemorraghic complications. From January 1994 onwards, anticoagulant therapy has been changed to using intravenous heparin sodium, reducing the difficulties in monitoring and eliminating the characteristic side effects of calcium heparine s.c. therapy. There have been no haemorrhagic complications in this second group.
Leukoplakic urethrotrigonitis in the female: Endoscopic treatment
Authors: Polledro P. , Ambruoso G. , Cordara G. , Borsa R. , Fontana G.
Published: July 2019

— Leukoplakic urethrotrigonitis is a frequently encountered phlogistic bladder pathology in the female. We present our experience of an endoscopic “peeling” treatment. Follow-up after 1 and 2 years shows a very high percentage of full recovery (94.3%).
Complications of Bacillus Calmette-Guerin immunotherapy in superficial bladder cancer
Authors: Vestita E. , Manassero A. , Terrone C. , Rossetti S. Rocca
Published: July 2019

— Intravesical immunotherapy with BCG has become a standard treatment of superficial recurrent transitional cell carcinoma and in-situ bladder carcinoma. Studies on the mechanism of action have demonstrated the role of T lymphocytes. Moreover clinical and experimental results suggest a role by cytochines and delayed type hypersensitivity. BCG, while effective in the treatment of bladder cancer, has a defined morbidity that can be ascribed to the fact that it consists of viable bacterial cells. We evaluated the complications and side effects of this therapy in 71 patients who had received intravesical BCG (Pasteur strain BCG was instilled weekly for 6 weeks, fortnightly for three months and monthly for 12 months at a dose of 75 mg). Our findings showed the following complications: cystitis (63.3%), hematuria (28.1%), fever (7%), two cases of pruritus (2.8%), one case of hepatitis with persistent fever. Granulomatous prostatitis was noted in four cases (5.6%), a higher incidence than reported in literature, but it is a localized and self-limiting process that does not require specific therapy. In conclusion, the treatment with intravesical BCG has a significant morbidity, but the rate of complications is low and most need no treatment.
Primary prostatic lymphoma: A rare case report
Authors: Tognoni P. , Banchero R. , Repetto U. , Caviglia C. , Cussotto M. , Oppezzi F. , Donelli A. , Medica M. , Schenone M. , Carmignani G.
Published: July 2019

— We present a rare case report of a non-Hodgkin primary prostatic lymphoma. In the article we focus on the increasing number of primary urologic lymphomas, the usual indolent clinical course of such a neoplasm and the combination of surgery and chemotherapy that we performed in this case.
Laparoscopic treatment of varicocele
Authors: Bianchi G. , Beltrami P. , Tallarigo C. , Giusti G. , Mofferdin A. , Malossini G.
Published: July 2019

— This paper reports the result of our experience on laparoscopic varicocele treatment. Fifty-two patients underwent ligation of the spermatic vein. In 34 patients the procedure was monolateral and in 18 bilateral. Disposable trocars were used for umbilical access; non-disposable trocars were used for the others. Operative time was comparable to that of traditional surgery. Short hospitalization (24–48 hours) and the rapid resumption of everyday activity give the laparoscopic approach a favourable cost/benefit ratio in comparison with standard open techniques.
Diagnostic strategies for the early detection of prostatic cancer
Authors: Benecchi L. , Bordinazzo R. , Caldera G. , Catania G. , Cazzaniga A. , Vercesi A. , Privitera O.
Published: July 2019

— We carried out an investigational study of early detection of prostate carcinoma, using digital rectal examination (DRE) and serum prostate specific antigen (PSA). We determined the detection rate and some profiles of the carcinoma detected by screening in men from 50 to 80 years old. The detection rate was 2.3% in 1345 participants. In 20 men (64.5%) the disease was T1c or T2 and in 16 patients we performed radical prostatectomy.
Flow cytometric DNA analysis in conservatively treated renal tumours
Authors: Beltrami P. , Lazzarotto M. , Giusti G. , Tallarigo C. , Malossini G. , Azzolina L.S. , Bianchi G. , Mobilio G.
Published: July 2019

— The DNA histograms of 21 conservatively resected renal tumours were studied using DNA flow cytometry. Five patients had an imperative and sixteen an elective indication for conservative resection of the renal tumour. On the basis of DNA histograms twelve aneuploid tumours were pointed out. A mean follow-up of 34.2 months was considered to see whether the ploidy would provide criteria with a prognostic significance, to be useful as an additional parameter. None of the twenty-one patients had local recurrence or distant metastasis: in our series the DNA analysis had no influence on the prognosis of this group of patients. The tumour size seems to be the only selective parameter for choosing renal-conserving surgery.
Nephrogenic adenoma of the bladder in renal transplant patients: Three clinical cases
Authors: Arena G. , Guermani P. , Manzo M. , Pigato M. , Alladio F. , Ferrando U. , De Natale A.
Published: July 2019

— The Authors report on three cases of nephrogenic adenoma of the bladder in a population of 796 renal transplant patients. According to their experience the Authors think that a more aggressive approach is advisable in transplant patients with frequent urinary tract infections and/or hematuria.
Flow cytometry in renal cell carcinoma
Authors: Fiaccavento G. , Belmonte P. , Zucconelli R. , Forgiarini O. , Chiara A. , Antonini C. , Sacchi G.
Published: July 2019

– The most important prognostic factors in renal carcinoma are the stage and grade. World literature is full of information on new markers, the analysis of DNA with the cytofluorimetric method being foremost, as it allows the cell lines in the neoplasm to be assessed and at the same time the ploidy and cell cycle stages to be studied. We have found an excellent correlation between the ploidy and cell grade. After a preliminary study we can conclude that the method is easy to perform and to reproduce. The procedure is also interesting for retrospective studies which allow the pathologist to select the blocks to be examined, thereby avoiding those widely contaminated by hemorrhages or necrosis.
Biological prognostic factors in renal cell carcinoma: Personal experience
Authors: Cortellini P. , Monica B. , Barbieri A. , Camisa R. , Bozzetti C. , Guazzi A. , Di Stefano C. , Borrini A. , Martella E. , Crafa P.
Published: July 2019

– Histological specimens from 95 RCCs were immunostained for p53 protein, E-cadherin and Ki-67 antigen. Results, as well as stage and grade, were correlated to overall survival and disease-free interval. Markers were also correlated to each other. Statistically significant correlations were observed between stage, grade and Ki-67 versus both overall survival and disease-free interval and between Ki-67 and grade. The authors conclude that the analysis of cell proliferation by Ki-67 immunostaining may help improve understanding of the RCC prognosis.
Hypospadias: Classification and criteria for surgery
Authors: Stracuzzi G. , Ranno S. , Minaldi G. , Leonardi R. , Turco M.G.
Published: July 2019

– The authors report on 579 cases of hypospadias operated between 1975 and 1995 (405 Balkan, 112 penile and 62 with involvement of the scrotum). The first 90 cases were treated with traditional techniques (45 Ombredanne, 25 Matthieu, 15 Duplay-Marion, 5 Brown), the most recent, from 1979 to 1995, by urethroplasty with pedunculated island strips. The authors describe these techniques applied to the various kinds of hypospadias and conclude that modern techniques (modified MAGPI, modified Standoli, Micali) permit reconstruction in one session with few complications.
Salvage cystectomy
Authors: La Rosa P. , Rotondo S. , Molino F. , Basilicò C. , Maccarrone G. , Aragona C.
Published: July 2019

– Radical cystectomy is still the best treatment today for patients with infiltrating bladder cancer, despite it being burdened by a high mortality rate at five years in the most aggressive forms and by a high possibility of metastasisation. In symptomatic patients after radiotherapy for actinic cystitis (also recurring), and in patients over seventy years old in poor general condition with locally advanced neoplastic forms, salvage cystectomy and “palliative” cystectomy respectively are in our opinion the only methods capable of guaranteeing an acceptable residual quality of life. This work consists of a retrospective analysis of the 9 patients (2 women and 7 men) who, between 1994 and 1996, underwent salvage and/or palliative cystectomy. We report a low rate of intra-operative complications and mortality in the immediate post-operative period. Early and late complications were at an acceptable level.
New strategems for optimising medical therapy of IPP with iontophoresis
Authors: Catuogno C. , Scalfari A. , Ventrice G.A. , Martino L.F. , Lanza P.
Published: July 2019

– In this work the authors report on their experience in treating 18 patients suffering from IPP with Verapamil and Dexamethasone administered by electrophoresis. The new feature of this treatment consisted of the three snap rings that were put on the penis (one at the base of the penis, one above and one below the electrode) during each session. Pain was totally eliminated in 12 patients and partially in 3, while there was a reduction in curvature of between 30 and 50% in 9. There was also subjective improvement in erection in 12 patients, as could be seen (in some) from the Doppler colour ultrasound and NPT test. The authors conclude that better results may be obtained with early treatment, careful selection of patients and association with other drugs.
Andrological surgery under local anesthesia
Authors: Catuogno C. , Scalfari A. , Ventrice G.A. , Martino L.F. , Lanza P.
Published: July 2019

– This work describes the authors’ experience with 454 patients operated under local anesthesia for andrological related diseases. Only six patients had side effects: 5 crises of stimulation of the vagus and 1 interruption of the operation due to pain. The authors conclude that local anesthesia is not only safe and well tolerated by the patient, who returns to his normal acitivity much quicker, but is also economical with regard to health care costs.
Biofeedback and functional perineal electro-stimulation in male urinary incontinence
Authors: Lamartina M. , Rizzo M. , Bianco A. Lo , Di Girolamo A. , Spanò V. , Camilleri G.
Published: July 2019

– The aim of the study is to evaluate the efficacy of biofeedback (BF) and of electrostimulation (SEF) of the perineal floor in male patients suffering from urinary incontinence. Eleven patients entered the study, five of them suffering from mixed urinary incontinence and six from pure stress incontinence. They were treated with six sittings of BF, SEF and domiciliary exercises. The results are promising. Additional monthly sittings and domiciliary SEF maintenance are advised.
Efficacia dell'ecotomografia intraoperatoria nella valutazione dei trombi cavali da adenocarcinoma renale
Authors: Trombetta C. , Liguori G. , Lodolo C. , Buttazzi L , Belgrano E.
Published: July 2019

Sometimes NMR, CT, cavography and abdominal ultrasonography are not specific enough for the correct staging of cranial extension of caval thrombus in patients with renal adenocarcinoma. We recently performed intraoperative ultrasonography (IU) in 3 such patients with caval thrombus. IU is a useful tool for enabling the surgeon to assess the anatomo-clinical picture more precisely and sometimes to perform a less invasive operation.
Ricostruzione cavale con patch di vena ovarica in un caso di adenocarcinoma renale con trombosi cavale intraepatica
Authors: Belgrano E. , Trombetta C. , Liguori G. , Siracusano S. , Buttazzi L. , Zincone B.
Published: July 2019

We report a case of caval reconstruction with ovarian vein patch in a patient suffering from renal adenocarcinoma with intrahepatic caval thrombosis. The size of the patch was 5×1.5 cm, allowing a cavai gauge of 2 cm to be obtained. The use of autologous material for caval reconstruction is a common technique with fewer complications than with heterologous material.
La chirurgia dell'induratio penis plastica (IPP) nel paziente anziano con conservata funzionalità erettile
Authors: Toia G. , Baroni G. , Bianchi A. , Bottanelli A. , Rovellini P. , Sciaraffia G. , Marcelli G.
Published: July 2019

Peyronie's disease also concerns people over sixty who still wish to lead a satisfying sexual life. The authors provide indications for a surgical technique allowing the best cost/benefit ratio for the patient and present their experience with the Nesbit technique.
Due casi di fibrosi retroperitoneale con risposta favorevole alla terapia corticosteroidea
Authors: Mastrooeni F. , D'amico A. , Novella G. , Isgrò A. , Guddemi A. , Paganelli A. , Tallarigo C.
Published: July 2019

Retroperitoneal fibrosis is rare and is usually treated with exploratory laparotomy. Satisfactory response to corticosteroid therapy has been shown, however, in cases with early retroperitoneal disease, while those with late disease show no improvement. Two cases are reported of patients with retroperitoneal fibrosis treated successfully with long-term corticosteroid therapy.
Valutazione ecografica e TC di pielonefrite acuta in paziente affetta da rene policistico
Authors: Lodolo C. , De Stefani S. , Moro U. , Lissiani A. , Mucelli F. Pozzi , Belgrano E.
Published: July 2019

Autosomal dominant polycystic kidney disease is a rare nephropathy consisting of multiple cysts that alter almost all the parenchyma of the organ, leading to renal failure. A clinical case with atypical presentation is described.
Amiloidosi polidistrettuale. Implicazioni urologiche
Authors: Schiavon L. , Bondavalli C. , Pegoraro C. , Dall'Oglio B. , Luciano M. , Canclini L. , Parma A.
Published: July 2019

Amyloidosis covers a group of morbid processes which have the common characteristic of amyloid being deposited in an extracellular site of one or more organs. The mechanisms causing amyloidogenesis are still unknown. Involvement of the urinary apparatus is more frequent with primary amyloidosis and myeloma (AL form) as well as inflammatory or neoplastic diseases (AA form). The disease in the kidney is characterised by proteinuria progressing to the nephrotic syndrome and renal failure, while frank hematuria is typical of the disease in the bladder. In our case emergency cystectomy was performed because of severe anemia consequent to hematuria. Prodromal symptoms were asthenia, loss of weight, purpura and subsequent to involvement of the urinary tract, also gastroenteric, cardiac, neurovegetative, articular and thyroid disorders typical of multi-district involvement. Diagnosis is confirmed only after the histological examination and average survival rate is 20 months. There is no fully effective therapy.
Carcinoma del pene: Chirurgia e chemioterapia
Authors: Iantorno R. , Nicolai M. , Cipollone G. , Peracchia G. , Mastroprimiano G. , Cortellini P. , Cataudo C. , Tenaglia R.
Published: July 2019

Spinocellular carcinoma of the penis is rare and potentially fatal, especially when there are lymph node metastases. From January 1992 to December 1995 we treated 6 stage T3 N1 M0 tumours of the penis. Six to eight weeks after total penectomy, bilateral inguinal lymphadenectomy and pelvic lymphadenectomy were carried out. These patients also underwent 8 cycles of chemotherapy with vincristine, bleomycin and methotrexate. At an average follow-up of 36 months, all the patients are disease-free with no signs of recurrence either in the lymph nodes or in any organ.
Deduzioni sulla terapia dei tumori vescicali nel paziente anziano
Authors: Dormia G. , Minervini M.S. , Malagola G. , Bertana F. , Gonnella G. , Mazza L , Luongo P. , Longo G.
Published: July 2019

Our experience over the last 5 years has been reviewed to assess the therapeutic choices in relation to the age of patients with bladder tumour. The results of TURB, partial cystectomy + radiotherapy (RV) and radical cystectomy (CX) were compared. Patients subjected to RV were on average older (69.9 years) than those treated by TURB and CX (67.6 and 65.3 years).
Retroperitoneal hematoma from spontaneous rupture of renal neoplasia
Authors: Pirritano D. , Spasari A. , Falvo F. , De Pasquale M. , Zagordi A. , Apollini L. , Martino L. , Sicuro O. , Scalfari A.
Published: July 2019

The authors describe 4 recently observed cases of retroperitoneal hematoma from spontaneous rupture of renal neoplasia. The aim of this report is to underline the problems concerning the pathogenesis, diagnosis, staging and therapy.
Papuliferous adenocarcinoma of the seminal vesicle: Clinical case
Authors: Cammarata C. , Paola Q. , Panarisi S. , Curto F. , Barbera M. , Solazzo G. , Curto G. , Nuciforo G.
Published: July 2019

The authors describe the case of a cylindrical cell papuliferous carcinoma of the right seminal vesicle in an 84-year-old man with prostatic adenocarcinoma. The heteroplasia of the seminal vesicle was detected during instrumental staging of the prostatic neoplasm. The unusual localisation of the neoplasm stimulated the authors to review the literature, diagnostic methods and possible therapies.
Enlargement urethroplasty using retrospongious epidermal flap
Authors: Palminteri E. , Barbagli G. , Mottola A. , Rizzo M.
Published: July 2019

Free or pedunculated skin flaps may be used to repair stenoses of the anterior urethra. The authors prefer using free preputial flaps in reconstructing the bulbar urethra which, having a spongy body, guarantees an adequate vascular and mechanical support for the transplanted flaps. The bulbar reconstruction technique uses an epidermal epithelial strip along the dorsal face of the urethra. The dorsal approach to the urethral channel prevents mechanical yielding of the transplanted area and consequent formation of symptomatic urethrocele. Dorsal enlargement urethroplasty has the advantage that invasion of both the area of skin removal and the urethral channel is reduced to a minimum.
The quality of life after cystectomy
Authors: Ingargiola G.B. , Di Girolamo A. , Lamartina M. , Tripi M. , Daricello G. , Melloni D. , Pavone-Macaluso M.
Published: July 2019

In this study the authors have tried to identify some useful parameters for assessing the quality of life after cystectomy: continence, sexual activity, electrolytic and acid-base balance alterations. Factors which could improve the quality of life after cystectomy include improving surgical techniques and the correct practice of informed consent, when the doctor should give as much information as possible on the therapeutic options, specifying the pros and cons and possible complications, while paying particular attention to the psychological aspects.
The fascial muscle valve in continent ileal pouches: Preliminary results
Authors: Aragona C. , La Rosa P. , Rotondo S. , Piccolo A.
Published: July 2019

This study aims at assessing a new type of continent cutaneous valve in terms of simplicity of construction and durability. The technique consists of making an ileal pouch with approx. 45 cm of detubularised intestine with the proximal 5 cm, reduced in calibre, anastomised to the skin through a fascial-muscle tunnel, thereby creating an unusual continence device. After 6 months, 2 of the 3 patients who were operated with this technique are continent and satisfied with the reservoir.
Atypical leiomuscular tumour of the prostate
Authors: Cammarata C. , Barbera M. , Curto F. , Panarisi S. , Paola Q. , Solazzo G. , Curto G. , Cabibi D.
Published: July 2019

Leiomyomas are an uncommon form of benign tumour composed exclusively or mostly of smooth muscle. They may involve any part of the genito-urinary apparatus, but are found most frequently in the renal capsule. The authors report the case of a leiomuscular type prostatic tumour with atypia making it impossible to define a malignant state with any certainty. It is emphasised that only the histological examination can decide since observation and instrumental examinations are not sufficient for diagnosis.
Female urinary stress incontinence: Instrumental diagnosis
Authors: Fondacaro L. , Morgia G.
Published: July 2019

A review was made of the diagnosis tools available today for assessing female urinary stress incontinence. Many investigators perform both functional and morphological examinations, but as yet there are no universally accepted guidelines to help in the choice.
Physiokinesitherapy in the treatment of female stress incontinence
Authors: Lopes M. , Savoca F. , Bartolotta S. , Nisticò C. , Ventimiglia B.
Published: July 2019

The authors report the results of treatment with physiokinesitherapy (PKT) in 36 women with stress incontinence (29 with genuine-stress incontinence and 7 with urge-stress incontinence). The therapeutic programme consisted of twelve 30-minute sessions, in which biofeedback was alternated with functional electric stimulation. Clinical evaluation included a self-assessment questionnaire, a physiatric visit and a urodynamic examination at 6 and 12 months after treatment. At the end of the PKT cycle, approx. 92% of patients had improved or recovered. After 6 months, however, 53% of patients had recovered, 33% had improved and 14% were stationary. After 12 months, in the 29 patients with genuine-stress incontinence, 66% had recovered, 24% had improved and 3% were stationary, while none of the patients with urge-stress incontinence had recovered (72% improved, 28% stationary). Our study confirms that PKT is helpful in treating urinary stress incontinence in women.
Bladder-vaginal fistulas: Technical notes
Authors: Savoca F. , Amuso G. , Caizzone F. , Morana C. , Nisticò C. , Salvia L. , Salvia G. , Nicolosi D.
Published: July 2019

Bladder vaginal fistulas are one of the most common urological pathologies. They are mostly of iatrogenic origin and are a great handicap, especially with regard to the quality of life of the patients. The authors report on the experience gained by working together with gynaecology departments, giving some case reports and the therapeutic strategies used.
Treatment of La Peyronie's disease with Verapamil and cryoelectrophoresis
Authors: Salvia G. , Potenza R. , Aloisi A. , Palazzolo F. , Amuso G. , Morana C. , Nicolosi D.
Published: July 2019

Over the years the treatment of induratio penis plastica has known many ups and downs, using many drugs administered in different ways (Potaba, vit. E, Nimesulide, Orgotein) associated or not with other drugs (Potassium iodide, Cortisone). Verapamil has been used in the last two years. It is a calcium antagonist drug commonly used by cardiologists in treating arrhythmia. It is administered by injection directly into the plaque at a dose of 5 mg a week and has given good results with regard to pain and curvature of the shaft during erection. We treated 40 patients from 1995 to 1997, 13 with injection into the plaque and 27 with a new method of drug transportation called cryoelectrophoresis. The physical principles of this method are referred to and the authors’ experience and results of IPP treatment are described.
Stimulatory effect of engineered three-layer adipose tissue-derived stem cells sheet in atelocollagen matrix on wound healing in a mouse model of radiation-induced skin injury
Authors: Zhang Yuanzheng , Li Dan , Fang Shuo , Li Xueyang , Zhang Huojun , Dai Haiying , Fan Hao , Li Yingli , Shen Di , Tang Weiya , Yang Chao , Xing Xin
Published: July 2019

To investigate the effectiveness of adipose tissue-derived stem cells sheet combined with atelocollagen matrix on a mouse model of radiation-induced skin injury, adipose tissue-derived stem cells were harvested from the bilateral groin of mice and were screened out by fluorescence-activated cell sorting. Cell sheets were created on a temperature-responsive cell culture surface. The wound recovery rate was detected by measuring the injury area and the recovery shapes of wound were monitored by hematoxylin–eosin, Masson’s trichrome, and immunohistochemical staining. Quantitative reverse transcription polymerase chain reaction and Western blot analysis were conducted to detect relative mRNA expression level of interleukin-1β and protein expression level of vascular endothelial growth factor, respectively. As results, the three-layer adipose tissue-derived stem cells sheet combined with atelocollagen matrix treatment promoted wound healing significantly compared to other treatments. More collagen, higher vessel density, and milder inflammation were observed in the group of three-layer adipose tissue-derived stem cells sheet combined with atelocollagen matrix compared with other treatments. Moreover, both mRNA expression level of interleukin-1β and protein expression level of vascular endothelial growth factor were drastically decreased in that group. In conclusion, three-layer adipose tissue-derived stem cells sheet combined with atelocollagen matrix could promote wound healing synergistically, providing a substantial advance in cell-based tissue engineering and wound healing.
Decellularised baby spinach leaves and their potential use in tissue engineering applications: Studying and promoting neovascularisation
Authors: Dikici Serkan , Claeyssens Frederik , MacNeil Sheila
Published: July 2019

Although significant progress has been made, delayed neovascularisation of tissue-engineered constructs still remains challenging for the survival of constructs post-grafting. The addition of laboratory expanded proangiogenic cells to tissue engineering scaffold systems prior to implantation is a promising approach to overcome the slow neovascularisation. The use of decellularised biological constructs is an emerging strategy for producing physiologically relevant scaffolds for use in both pre-clinical and clinical applications. Decellularised plant architectures have recently been proposed as one approach – here we seek to confirm and extend this work by preparing baby spinach leaves without damaging their intrinsic vascular architecture and to explore their efficacy once seeded with cells to promote neovascularisation in a chick bioassay of neovascularisation. Firstly, the in vitro biocompatibility of the decellularised spinach leaves and the effect of gelatin coating on cell attachment and proliferation were assessed. The decellularised leaves showed no toxicity to cells, and gelatin coating and the presence of fibroblasts enhanced the survival of human endothelial cells in the scaffolds. The proangiogenic activity of these cell populated scaffolds was then investigated in ex ovo chick chorioallantoic membrane assay where the presence of the endothelial cells significantly promoted angiogenesis over seven days. In conclusion, these results support a small but growing body of literature that suggests the use of decellularised plants as potential scaffolds to promote neovascularisation for tissue engineering constructs.