bluuebunny/crossref_metadata_2025 huggingface dataset:
The Verbal Aggression of Spectators at Youth Baseball Games: Investigating the Impact of Competition Level, Team Identification, and Fan Dysfunction
Authors: Wann Daniel L. , Sherman Michelle R.
Published: September 2019

Previous research had found that level of team identification was positively associated with aggression at youth sporting events (Wann, Weaver, Belva, Ladd, & Armstrong, 2015).  The current investigation was designed to extend this work by incorporating fan dysfunction into the model (i.e., fans who are confrontational and frequently complain).  Spectators at either a recreational or select (i.e., travel) youth baseball game completed a survey packet assessing demographics, team identification with their favorite Major League Baseball team, identification with the youth team, fan dysfunction, and hostile and instrumental verbal aggression directed toward officials and opponents.  Results indicated that, contrary to expectations, team identification was not a unique predictor of verbal aggression.  Rather, fan dysfunction predicted each form of aggression, aggression toward both targets, and total aggression.
Challenges of an established amateur sport: Exploring how wheelchair basketball grows and thrives through a sport development lense
Authors: Pate Joshua R , Bragale Danielle
Published: September 2019

Wheelchair basketball has been played in the United States for more than 70 years, and the National Wheelchair Basketball Association (NWBA) governing body has professionalized the sport to some extent with a league and culminating annual championship for its eight divisions. However, teams continue to face challenges that characteristically align with those of amateur sport in addressing recruiting and retaining athletes. The purpose of this study was to examine the challenges elite, competitive wheelchair basketball programs face and to understand their approach to recruiting and retaining athletes with disabilities to play the sport. Green’s (2005) theory of sport development was chosen as the lens for this study because of its focus on establishment of a sport for sustainability through athlete participation. An online open-ended questionnaire was sent to all 139 NWBA team contacts, with 28 responses representing multiple divisions within the league. Findings revealed that teams were primarily formed through unstable means of personal interest and community needs as well as stable means of university and rehabilitation hospital systems. Participants identified funding as the biggest challenge as they offered little support for tournament travel or financial rewards for athletes. Teams recruited athletes through social connections and community presence, but offered little structure for their means of retaining athletes. These findings show the NWBA teams operate with challenges akin to amateur sport due to uncertainty of funding and athlete sustainability.
Phenotypic analysis of circulating leukocytes v1
Authors: Davis Coakley John
Published: September 2019

Antibody panels for flow cytometry were prepared with specific antibodies for identification of lymphocyte populations, and antibodies specific to IL-23 receptor andIL-12 receptorβeta-2 subunit. Single stains were used for compensation controls and fluorescence minus one (FMO) controls were used to help set gates for flow cytometry.
Financial Analysisof Rain Water Harvesting Tools in Pamor Hamlet, Banjardowo Village, Kradenan Sub District, Grobogan District
Authors: Jariyah Nur Ainun , Purwanto Purwanto
Published: September 2019

The drought that occurs in the dry season is one of the hydrometeorological disasters. A total of 82 villages of 12 districts in Grobogan, Central Java, experience a clean water crisis due to drought because the well, as their main source of water, is likely to go dry. Therefore, a solution is needed to anticipate the water shortage. The aims of this paper is to analyze financially the water harvesting building which can be used as a reference for the community. The research was conducted in Pamor Hamlet, Banjardowo Village, Kradenan District, Grobogan Regency. The method used was to build the rainwater harvesting engineering models, namely (a) recycling tools for washing and bathing, (b) dirt filter wells, (c) three meters depth infiltration wells (1 well and 2 wells), and (d) five meters deep infiltration wells (1 well and 2 wells). Data collection was done by conducting a survey of the community. The data collected were the costs required for the construction of the rainwater harvesting equipment, maintenance, electricity, supporting materials, etc. The income was approached with replacement costs if the community buys water during the dry season. The financial analyses of NPV, IRR, BCR, and PP were employed. The results showed several feasible models to be applied, namely recycling equipment for washing and bathing, dirt filtering equipment, three meters deep infiltration wells (1 piece) and a depth of 5 meters (1 piece). This model is very good to be adopted by the community because it is easy and has minimal costs.
Effect of Mother Trees and Cuttings Material Position on the Stool Plants to Shorea leprosula Shoot Cuttings Growth
Authors: Mashudi Mashudi
Published: September 2019

Vegetative propagation plays an important role to support Shorea leprosula’s clonal forestry development. This study aimed to determine the effect of mother trees and cuttings material position of S. leprosula shoot cuttings growth at 4 months of age. Complete Randomized Design (CRD) was used as the experimental design, which consists of two factors, i.e. cuttings material position (4 level) and mother trees (10 mother trees). The results showed that the interaction between mother trees and cuttings material position significantly affected the growth of height and the number of the leaf. The best interactions in height of growth values ranged from 7.83 to 8.83 cm and the best number of leaves ranged from 3.6 to 4.5 sheets. The single factor of the cuttings material position and mother trees significantly affected the rooting percentage, the number of the root, and the length of the root. The cuttings material position at 20 cm, 40 cm, and 60 cm found to be the best rooting percentage (84 to 88%), the cuttings material position at 40 cm and 60 cm found to be the best number of the root (4.04 to 4.43 pieces) and the best length of the root (10.23 to 10.93 cm).
Degraded Land Analyses of Brantas River Basin to Support Land Rehabilitation
Authors: Wahyuningrum Nining - , Putra Pamungkas Buana
Published: September 2019

Land degradation in the Brantas River Basin occurs very massively as reflected by high erosion and sedimentation. Information related to soil erosion is important since it is one of the basic information in determining the degraded land in a watershed. The purpose of this study was to analyze and identify the distribution of degraded land in the Brantas river basin as an effort to mitigate land degradation through forests and land rehabilitation in suitable locations. Erosion analysis was carried out spatially on a watershed scale using the USLE (Universal Soil Lost Equation) method. Analyses showed that weighted soil erosion values in the Brantas river basin were 448.73 tons/ha/year which was classified as high erosion level. The area of 408,818 ha (41.74%) of Brantas river basin needs erosion handling because 22.51% was identified in the high erosion value category and 19.23% was included in very high erosion values. Those areas were identified as protected forests, production forests, dry land, and mixed gardens. The type of soil and the erodible of soil are part of the determinants of the high value of erosion, but these factors are difficult to manage while land cover types and land management which are the causes of erosion are relatively manageable. The approach to rehabilitate forests and land can be used as an effort to prevent and reduce erosion by taking into account the selection of related types of habitus (form and stratification) and economic value.
Morphology and Genetic Diversity of Jabon Putih Seedling from 4 Populations in Sumatra, Nusa Kambangan, Kalimantan, and Sulawesi
Authors: Rustam Evayusvita - , Sudrajat Dede J.
Published: September 2019

Jabon putih (Neolamarckia cadamba) is a widely distributed potential fast-growing species and is thought to be associated with extensive genetic diversity. The aim of the research was to assess the morphological and genetic variation of jabon putih seedling based on AFLP markers. Randomized block design with 4 replications was used to assess seedling morphological variation on 31 families from 4 populations (Kapuas, Kampar, Nusa Kambangan, Pomalaa) based on traits of seedling height, diameter, sturdiness quotient, number of leaves, leaf length, and leaf width at nursery. AFLP Analysis System I Kit by using dry leaf samples from each family was used. Characteristics of jabon putih seedlings had variation among populations and families within population. Genetic variation within population based on morphological traits had the similar trend with result of AFLP analysis. The highest genetic variation was detected in Kapuas population, followed by Pomalaa, Nusa Kambangan, and Kampar populations. Cluster analysis and UPGMA method had 2 cluster and put down most of families from Kapuas in one cluster separated from other families. Based on the genetic similarity analysis, 26 families could be considered as potential families for the establishment of breeding populations. The study has important practical implications for genetic resources management and for future breeding programs of jabon putih.
The Development of Non-Tax State Revenue Potency by Applying the Logical Framework Approach: A Case Study of Nagrak Research Station in Bogor District, West Java
Authors: Wisudayati Tri Astuti , Hidayat Dian Charity , Sudrajat Dede J
Published: September 2019

The Indonesian government strives to increase non-tax state revenues (PNBP). One of the potentials PNBP is using the state assets, such as research stations, for the public interest. This paper was aimed to formulate a strategy for the PNBP potential development using the Logical Framework Approach (LFA), with a case study at the Nagrak Research Station, Bogor. In order to avoid the failure when the PNBP potential development’s stages are implemented, policy makers need to build a hierarchy based on logical thinking of input, activity, output, impact, objectives and summarized them in a work plans matrix. The process of LFA development starts with the analysis of problems, goals, and strategies. Data and information were obtained through participant observation and documentation studies. The results showed that the commercialization of the operational units of research quality’ s seeds and seedlings at the Nagrak Research Station must be supported by the government policy, including: (1) planning of seed and seedling production with the consideration of price competitiveness (2) seeds and seedling production with the financial management flexibilities, and (3) seeds and seedling distribution with stakeholders protection from the non-quality seeds and seedling’s utilization.
Qualidade nutricional e parâmetros morfológicos do fruto cajá (Spondias Mombin L.)
Authors: Silvino Rayssa , Silva Graziela , Dos Santos Orquídea Vasconcelos
Published: September 2019

O aumento no consumo e na produção de frutas tropicais promove a necessidade de pesquisas direcionadas a novas vertentes de compostos Nutricionais e funcionais da biodiversidade Amazônica. Assim, o objetivo desta pesquisa e rastrear a qualidade nutricional-funcional e os parâmetros morfológicos do fruto cajá (spondias mombin l.). As bases metodológicas e métodos aplicados seguem o padrão de análise internacionalmente aceitas indicados pela Association of Official Analytical Chemists (AOAC). Os resultados obtidos apresentaram um fruto de considerável valor nutricional com baixo valor energético e alta relevância em compostos funcionais com a vitamina C com médias de 25,37 mg ácido ascórbico/100g e seu teor de carotenoides totais o valor médio de 1498,57 (?g.100g-1) mostrando a relevância desse fruto em provitamina A. As micrografias das estruturas mostram  uma matriz vegetal com presença de fibras e de raros grânulos de amido. A presença de fibras e das vitaminas A e C nesta composição aliado com seu baixo valor energético mostra a capacidade de prevenção de determinadas patologias que o consumo deste fruto pode oferecer.
An Example of Empirical and Model Based Methods for Performance Descriptors: English Proficiency Test
Authors: ARIKAN Serkan , KİLMEN Sevilay , ABİ Mehmet , ÜSTÜNEL Eda
Published: September 2019

Great
emphasis is given to the development of high-stake tests all around the world
and in Turkey. However, limited emphasis is given to adequate score reporting.
Too much emphasis on rankings and almost no emphasis on performance level
descriptors (meaning of the scores) have leaded a “ranking culture” in Turkey.
There is an immense need to raise awareness about score reporting and
performance level descriptions in Turkey. This study aims to raise awareness
about the use of performance level descriptors in a high-stake exam in Turkey,
an English proficiency exam. The study sample is consisted of 630 undergraduate
students who took the 2016-2017 English proficiency exam of a public university
in the southwest of the Turkey. In order to identify the potential exemplars,
two types of item mapping methods (i.e. experimental based method and
model-based method) were used in the present study. Item grouping for
performance level descriptors provided hierarchical and interpretable
structure. Using these performance level descriptors, it is possible to give
criterion referenced feedback to each student about his/her reading abilities.
The Influence of Using Plausible Values and Survey Weights on Multiple Regression and Hierarchical Linear Model Parameters
Authors: TAT Osman , KOYUNCU İlhan , GELBAL Selahattin
Published: September 2019

In
large-scale assessments like Programme for International Students Assessment
(PISA) and the Trends in International Mathematics and Science Study (TIMSS),
plausible values are often used as students’ ability estimations. In those
studies, stratified sampling method is employed in order to draw participants,
and hence, the data gathered has a hierarchical structure. In the context of
large-scale assessments, plausible values refer to randomly drawn values from
posterior ability distribution. It is reported that using one of plausible
values or mean of those values as independent variable in linear models may
lead to some estimation errors. Moreover, it is observed that sampling weights
sometimes are not used during analysis of large-scale assessment data. This
study aims to investigate the influence of three approaches on the parameters
of linear and hierarchical linear regression models: 1) using only one
plausible value, 2) using all plausible values, 3) incorporating sampling
weights or not. Data used in the present study is obtained from school and
student questionnaires in PISA (2015) Turkey database. Results revealed that
the use of sampling weights and number of plausible values has significant
effects on regression coefficients, standard errors and explained variance for
both regression models. Findings of the study were discussed in details and
some conclusions were drawn for practice and further research.
Development of Selcuk Sexual Development Scale (36-72 Months)
Authors: ALPTEKİN Ayşe , TEPELİ Kezban
Published: September 2019

Bu araştırma, 36-72 aylık normal gelişim gösteren çocukların, cinsel kimlik
ve cinsiyete ilişkin davranışlarını belirlemek için çocuktan ve aileden bilgi
edinmeyi hedefleyen geçerli ve güvenilir ölçme araçlarının geliştirilmesini
amaçlamıştır. Araştırma nicel araştırma yöntemlerinden genel tarama modelinde
tasarlanmıştır. Selçuk Cinsel Gelişim Ölçeği’nin (SECGÖ, 36-72 Ay) Cinsel
Kimlik Alt Ölçeği çocuk formu, Cinsiyete İlişkin Davranış Alt Ölçeği çocuk
formu, Cinsel Kimlik ve Cinsiyete İlişkin Davranış Alt Ölçeği aile formu olmak
üzere üç farklı alt ölçeğin geçerlik ve güvenirlik analizi yapılmıştır.
Verilerin analizinde SPSS 20, LİSREL 8.80 ve FACTOR yazılımı kullanılmıştır.
Çalışmanın hedef evrenini 2017-2018 yılları arasında Konya ili merkez
ilçelerinde ikamet eden 36-72 aylık normal gelişim gösteren çocuklar
oluşturmaktadır. Açımlayıcı Faktör Analizi sonucunda SECGÖ Cinsel Kimlik Alt
Ölçeği çocuk formu için sekiz maddelik iki faktörlü yapı, Cinsiyete İlişkin
Davranış Alt Ölçeği çocuk formu için sekiz maddelik tek faktörlü yapı, Cinsel
Kimlik ve Cinsiyete İlişkin Davranış Ölçeği aile formu için 18 maddelik iki
faktörlü yapı elde edilmiştir. Bu yapıların Doğrulayıcı Faktör Analizi
sonuçları yapıların modele uyumunu göstermiştir. Ölçeklerin güvenirlik katsayıları,
Cinsel Kimlik Alt Ölçeği çocuk formu için .61, Cinsiyete İlişkin Davranış Alt
Ölçeği çocuk formu için .66, Cinsel Kimlik ve Cinsiyete İlişkin Davranış Alt
Ölçeği aile formu için .85 olarak hesaplanmıştır.
Inadvertent Use of ANOVA in Educational Research: ANOVA is not A Surrogate for MANOVA
Authors: AKBAY Lokman , AKBAY Tuncer , EROL Osman , KILINÇ Mustafa
Published: September 2019

ANOVA and MANOVA
address different research questions and decision on conducting one or the
other of these tests relies on the research purpose. One prominent illegitimate
analysis of multivariate data is developed out of conducting multiple ANOVAs
rather than conducting a MANOVA. Another common mistake about MANOVA
applications is the use of improper post hoc procedure. Post hoc procedures are
needed to determine why the null hypothesis was rejected. Although the correct
post hoc procedure for MANOVA is descriptive discriminant analysis (DDA), many
researchers fail to conduct DDA to interpret their MANOVA results. The purpose
of this study is two-fold; (1) we aim to emphasize the theory behind the MANOVA
and its appropriate post hoc procedure and make clear distinction between
surrogate statistical procedures such as ANOVA; and (2) this study also
investigates the extent of incorrect analysis of multivariate dependent
variables in educational research in Turkey. First, we provided a small
simulation study to demonstrate the extent to which multiple ANOVAs yields
contradictory results when they are inadvertently used to test group mean
differences on multiple dependent variables. Results of the simulations
indicated that MANOVA and multiple ANOVAs had severe disagreements under many
conditions. Disagreement rate is elevated under the conditions where MANOVA
retains the null hypothesis. Then, we systematically reviewed the archives of
three education journals, which are classified as higher-, medium, and lower
quality journals. Results indicated that correct use of MANOVA with its proper
post hoc procedure is not common practice across educational researchers who
publish in Turkish education journals.
Investigation of Item Selection Methods According to Test Termination Rules in CAT Applications
Authors: SULAK Sema , KELECİOĞLU Hülya
Published: September 2019

In this
research, computerized adaptive testing item selection methods were
investigated in regard to ability estimation methods and test termination
rules. For this purpose, an item pool including 250 items and 2000 people were
simulated (M = 0, SD = 1). A total of thirty computerized adaptive testing
(CAT) conditions were created according to item selection methods (Maximum
Fisher Information, a-stratification, Likelihood Weight Information Criterion,
Gradual Information Ratio, and Kullback-Leibler), ability estimation methods
(Maximum Likelihood Estimation, Expected a Posteriori Distribution), and test
termination rules (40 items, SE < .20 and SE < .40). According to the
fixed test-length stopping rule, the SE values that were obtained by using the
Maximum Likelihood Estimation method were found to be higher than the SE values
that were obtained by using the Expected a Posteriori Distribution ability
estimation method. When ability estimation was Maximum Likelihood, the highest
SE value was obtained from a-stratification item selection method when the test
length is smaller then 30. Whereas, Kullback-Leibler item selection method
yielded the highest SE value when the test length is larger then 30. According
to Expected a Posteriori ability estimation method, the highest SE value was
obtained from a-stratification item selection method in all test lengths. In
the conditions where test termination rule was SE < .20, and Maximum
Likelihood Ability Estimation method was used, the lowest and highest average
number of items were obtained from the Gradual Information Ratio and Maximum
Fisher Information item selection method, respectively. Furthermore, when the
SE is lower than .20 and Expected a Posteriori ability estimation method was
utilized, the lowest average number of items was obtained through
Kullback-Leibler, and the highest was obtained through Likelihood Weight
Information Criterion item selection method. In the conditions where the test
termination rule was SE < .40, and ability estimation method was Maximum
Likelihood Estimation, the maximum and minimum number of items were obtained by
using Maximum Fisher Information and Kullback-Leibler item selection methods
respectively. Additionally, when Expected a Posteriori ability estimation was
used, the maximum and minimum number of items were obtained via Maximum Fisher
Information and a-stratification item selection methods. For the cases where
the stopping rule was SE < .20 and SE < .40 and Maximum Likelihood
Estimation method was used, the average number of items were found to be
highest in all item selection methods.
NEW TREATMENT OPTION FOR ESOPHAGOGASTRIC ANASTOMOTIC LEAK: A CASE REPORT
Authors: Davydov M. M. , Abdullaev A. G. , Malikhova O. A. , Tsigankova A. V.
Published: September 2019

The formation of esophagogastric anastomosis has a long history due to the search for the most reliable and safe fistula. The use of invagination anastomosis, proposed in the early 90s by Professor M.I. Davydov, fully met all the requirements, allowing significantly improve the quality of life of patients and significantly reducing the frequency of failure of the anastomoses to 0.5%.

Case description. We present the case of proximal gastric cancer invading the lower thoracic esophagus. The patient underwent proximal subtotal gastric and lower thoracic esophageal resection using the combination of a laparotomy and right thoracotomy. Contrast radiography performed on day 11 after surgery revealed esophagogastric anastomotic leak. The patient underwent urgent surgery.

Conclusion. This article presents a new treatment option for esophagogastric anastomotic leak by using endoscopic transesophageal clipping of the defect in combination with sanitation and drainage of the pleural/mediastinsl cavity. The proposed technique can be considered as a minimally invasive treatment method and can be used in any surgical clinic.
CRYOSURGERY IN THE TREATMENT OF LIVER CANCER: A CASE REPORT
Authors: Merzlikin N. V. , Petrov L. U. , Tskhai V. F. , Pshenichnikova E. A. , Sarueva A. P.
Published: September 2019

Background. Hepatocellular carcinoma is the most common liver cancer and is a leading cause of cancerrelated death worldwide. Its aggressiveness and extensive dissemination lead to a poor patient prognosis. The 5-year survival rate does not exceed 15 %. Despite advances in imaging techniques, its curable rate remains low, because signs and symptoms of liver cancer do not usually appear until the late stages. There is no standard curative treatment for advanced liver cancer.

Description. We present the case of a 56- year-old female patient with stage T3N0M0 hepatocellular carcinoma. The patient had a tumor of 20 cm in diameter and 2400 g in weight. The patient underwent right hemihepatectomy and cryodestruction of the liver stump along the resection margin. No evidence of tumor recurrence was found with a follow-up of 12 years.

Conclusion. Cryodestruction of the liver stump along the resection margin increases the potential for a higher cure rate in patients with hepatocellular carcinoma, even in cases of extensive organ damage in the absence of metastasis and tumor ingrowth into surrounding organs.
UNCONVENTIONAL FRACTIONATION RADIOTHERAPY REGIMENS IN TREATMENT OF INOPERABLE LUNG CANCER
Authors: Gogolin D. V. , Gulidov I. A. , Medvedeva K. E. , Ragulin Y. A. , Mardinsky Y. S. , Ivanova I. N. , Kursova L. V. , Kotuhov I. I. , Buksha A. Y.
Published: September 2019

The purpose of the study was to compare the efficacy and toxicity of hypofractionated versus hyperfractionated radiotherapy in patients with inoperable lung cancer.

Material and Methods. Patients with inoperable lung cancer, who were treated between 2014 and 2017, were assigned to undergo radiotherapy in two arms: accelerated hypofractionated conformal radiotherapy arm with 70 patients (60 Gy in 25 fractions, with 2.4 Gy per fraction) and accelerated hyperfractionated radiotherapy with 49 patients (60–70 Gy with 1–1.5 Gy per fraction). At the same time, platinum-based chemotherapy was applied.

Results. The rates of partial response, complete response, stable disease and progressive disease were 44.3, 7.2, 38.5 and 10.0 %, respectively in patients with hypofractionated conformal radiotherapy arm. The corresponding values were 71.4, 6.1, 16.4 and 6.1 %, respectively in patients with hyperfractionated radiotherapy arm. The 2-year overall survival rate was 62.8 % for the hypofractionated group and 58.1 % for the hyperfractionated group. Esophagitis III grade was observed in 4 (5.7 %) patients of the hypofractionated group and in 3 (6.5 %) patients of the hypofractionated group. Pneumonitis III grade was reported in 2 (2.9 %) patients in the hypofractionated radiotherapy arm and in 4 (8.7 %) patients in the hyperfractionated radiotherapy arm.

Conclusion. Results of the study showed that 3D-conformal hypofractionated radiotherapy combined with concurrent chemotherapy resulted no in severe radiation-induced complications, and demonstrated satisfactory short-and long-term treatment outcomes.
PROSPECTS FOR SEARCHING MULTITARGET TOPOISOMERASE INHIBITORS WITH ANTITUMOR PROPERTIES
Authors: Treshchalin M. I. , Neborak E. V. , Treshchalina H. M.
Published: September 2019

Purpose of research: to identify the prospects of search for new antitumor non-camptothecin inhibitors of topoisomerase I/II among the various chemical compounds based on the analysis of side effects.

Material and Methods. The analysis included 65 relevant literature sources for 2002–2018 years, found in Systems such as Scopus, Web of Science, Pubmed, and eLIBRARY.

Results. The antitumor and side effect characteristics of the agents, associated with the selective suppression of the activity of type I and/or II topoisomerase (Top1, Top2) in tumor cells were emphasized. Examples of the relationship between side effects of inhibitors and their structure and catalytic mechanisms were given. The following factors were highlighted as significant: 1) blocking of cells in G2 and S phases with a delay of entry into mitosis; 2) inhibition of the reaction of re-ligation with DNA breaks without re-linking; 3) launching of cytotoxic events with the inhibition of DNA replication and generation of double-strand breaks. Incurable cancers, such as gastric cancer, colorectal cancer, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma, etc. were determined as more sensitive to inhibitors. Side effects of treatment and their connection with the mechanism of activity were described.

Conclusion. Based on the comparative analysis of prognostically valuable data regarding the efficacy and safety of topoisomerase I/II inhibitors, multitargeted heterocyclic condensed nitrogen-containing compounds, in particular, anthrafurans, can be considered as new promising clinical candidates with higher selectivity of action.
THE VALUE OF PET/CT IN THE DIAGNOSIS, STADING AND MONITORING OF COLORECTAL CANCER
Authors: Chernov V. I. , Goncharova N. M. , Goldberg V. E. , Dudnikova E. A. , Zelchan R. V. , Medvedeva A. A. , Sinilkin I. G. , Bragina O. D. , Avgustinovich A. V. , Goldberg A. V. , Ermolenko R. V. , Popova N. O. , Simolina E. I. , Vysotskaya V. V.
Published: September 2019

The purpose of the study was to provide up-to-date data on the efficacy of positron emission computed tomography (PET) for the diagnosis, assessment of tumor extension and monitoring of colorectal cancer.

Material and Methods. The Medline and Pubmed databases were used for searching for publications devoted to clinical trials of diagnostic value of PET with 18F-Ftordesoxyglucose (PET with 18F-FDG).

Results. Data on the value of PET with 18F-FDG in visualization of the primary tumor, detection of lymph node and distant metastases and assessment of the treatment response in patients with colorectal cancer were presented.

Conclusion. PET with 18F-FDG was shown to be a promising imaging method for colorectal cancer. It is the most sensitive method in the detection of liver metastases. 18F-FDG PET is particularly superior to CT and MET in the ability to assess tumor response to treatment and predict early tumor response to therapy. The development of new radiopharmaceuticals for the diagnosis, staging, monitoring and prediction of colorectal cancer is of great importance.
Comparative analysis of anatomic parameters of the eyeball in children with ametropia, congenital glaucoma, aphakia and artiphakia
Authors: Khamraeva L. S. , Bobokha L. Yu. , Abdurakhmanova Ch. K. , Makhmudova Z. A.
Published: September 2019

Purpose. To conduct a comparative analysis of the anatomical parameters of the eyeball in children with ametropia, congenital glaucoma, aphakia and artiphakia.

Material and methods. The study involved 73 patients (146 eyes) aged 5 to 12 years with ametropia, congenital glaucoma, aphakia and artiphakia and was carried out on an ultrasonic device STRONG 6000 T in the A-scan mode with the 10 MHz sensor set for three points.

Results. A significant increase in the size of axial length of the eyeball in moderate and high myopia and in the vertical size in high myopia were revealed. In high hyperopia, sagittal dimensions were reduced while the transverse dimensions were a bit greater than the sagittal ones. In far-advanced stage of congenital glaucoma, a significant increase in eyeball dimensions was noted both in the axial direction and in the transverse — horizontal direction. No significant differences in sagittal and transverse dimensions were noted in aphakia and artiphakia.

Conclusion. For a comprehensive assessment of the clinical course of the disease, in particular as concerns the condition of the fibrous capsule of the eye in children with ametropia, congenital glaucoma, aphakia and artiphakia, echobiometric indicators characterizing sagittal and transverse (vertical and horizontal) sizes of the eyeball should be taken into account.
Retinopathy of prematurity and retinoblastoma: materials of the scientific and practical conference
Authors: Editorial Artiсle
Published: September 2019

On April 4–5, 2019, the Russian Helmholtz National Medical Research Center of Eye Diseases held a scientific and practical conference with international participation «Retinopathy of prematurity and retinoblastoma 2019». The conference, which became a platform for discussion of the most acute and burning issues of pediatric ophthalmology, was a great success. The proceedings reflect the state-of-the-art in the treatment of infants and children with retinopathy of prematurity and retinoblastoma, new technical and methodological solutions, controversial issues, and future prospects.
Pathogenesis and clinical features of congenital stationary night blindness in case of c.283delC NYX gene mutation
Authors: Ivanova M. E. , Gorgisheli K. V. , Zolnikova I. V. , Atarshchikov D. S. , Barh D. , Salmasi Zh. M. , Balashova L. M.
Published: September 2019

The complete form of X-linked congenital stationary night blindness (CSNB) is a rare genetic disease caused by a mutation in the NYX gene. CSNB is associated with the mutations taking place in 17 genes, whilst its CSNB1A form is caused by the mutations in the NYX gene, which were characterized earlier, although nothing had been reported so far about the Russian founder principle. The paper analyzes the pathogenetic mechanisms in a family with diagnosed CSNB1A and a new genetically confirmed mutation in the NYX gene in four members of one Russian family. Two brothers of the four siblings (two boys, two girls) with congenital stationary night blindness, diagnosed in early childhood, and high myopia underwent a standard ophthalmic examination, supplemented with OCT, electroretinography and color blind test with tables by Rabkin and Farnsworth test, whereupon they were sent to molecular genetics confirmation of the diagnosis by whole exome sequencing with subsequent Sanger sequencing confirmation of the detected mutation in the proband and proband’s relatives. In members of the family with clinical features of CSNB1A the reading frame shift mutation was genetically confirmed in the NYX gene (c.283delC, p.His95fs, NM_022567.2). This mutation is inherited in X-linked form. This is the first report of a case with a novel and probable founder mutation from Russia associated with CSNB1A. Since the mRNA of a NYX gene consists of only 2696 base pairs, a gene replacement therapy, or CRISPR-based gene editing, or a similar approach may be envisaged for the correction of frameshift in His95fs position.
Drainage devices in refractory glaucoma surgery
Authors: Anisimov S. I. , Anisimova S. Yu. , Arutyunyan L. L. , Voznyuk A. P.
Published: September 2019

Glaucoma is a socially sensitive disease, being one of the leading causes of irreversible visual impairment and blindness. Refractory glaucoma is one of the most severe forms of the disease as it is resistant to conservative and surgical methods of treatment. Because of pronounced postoperative fibroblastic activity of eye tissues, leading to gross scarring and obliteration of outflow paths, modern materials and methods of drainage surgery are needed. The review presents a variety of drains used today and considers in detail their main characteristics and the biocompatibility of the material used with eye tissues. Various groups of implants are presented, whose effectiveness and safety are compared and assessed. The statistics of postoperative complications and long-term results of surgical treatment are given.
Projeto Ítaca: por um saber sobre drogas a partir do campo educacional
Authors: OLIVEIRA Douglas Casarotto de , CORRÊA Guilherme Carlos
Published: September 2019

Este artigo trata de apresentar e problematizar a experiência do Projeto Ítaca Escola de Redução (ERD), onde tem sido possível desenvolver um processo de experimentação e invenção de uma perspectiva educacional sobre o campo das drogas que emerge dos saberes oriundos das práticas dos redutores de danos do Rio Grande do Sul. Para isso, realizou-se um recorte de tal experiência, que o ocorreu entre os anos de 2013 e 2015. Como método a apresentação deste percurso, dois momentos foram traçados. Num primeiro, realizou-se uma genealogia do projeto Ítaca, apontando suas proveniências e momento de sua emergência num cenário de transição da Redução de Danos. Num segundo momento, a partir de um olhar cartográfico apresentamos alguns pontos de aprendizado a partir das práticas da Ítaca ERD, apontando para um movimento de atualização da Redução de Danos (RD), a qual se dá a partir das pessoas envolvidas com a RD, na articulação da noção de RD com outros dispositivos do SUS e da reconfiguração da noção de campo.
Representações Sociais da violência doméstica em comentários de rede social
Authors: LEANDRO Maiara , GIACOMOZZI Andréia Isabel , FIOROTT Juliana Gomes , MARX Djenifer
Published: September 2019

No Brasil, mesmo com a implementação da Lei Maria da Penha, que visa proteger as mulheres, ainda existe um alto índice de feminicídio. Entende-se que por se tratar de um país com cultura machista e patriarcal há uma banalização da violência contra a mulher. Deste modo, esta pesquisa pretendeu analisar, através de um estudo documental com abordagem qualitativa, as Representações Sociais (RS) acerca da violência doméstica compartilhadas nas redes sociais. A pesquisa de RS em espaços virtuais permite ao pesquisador obter um material inédito e diferente do obtido pelas formas mais tradicionais de pesquisa. Foram analisados 133 comentários sobre uma reportagem divulgada através da rede de programação jornalística brasileira chamada Globo, conhecida por sua visibilidade. Para análise dos dados, foi realizado análise categorial temática. Os resultados obtidos indicaram que as RS veiculadas nos comentários dizem respeito a necessidade do cumprimento da legislação, também a culpabilização da mulher vítima de violência por não ter saído da relação abusiva. Também culpabilizam o homem ator de violência, mas este é visto como doente ou monstro. Observou-se questões vinculadas à religião como uma possibilidade de sentido, mas ao mesmo tempo, de conformismo. Ademais houve o acolhimento a mulher, mas violência deve ser resolvida com violência. Concluiu-se as RS sobre este fenômeno é polarizada, pois ora culpabilizam o homem, ora a mulher, entretanto não levam em consideração de que ambos foram educados na mesma cultura. E ainda é necessário maior envolvimento do poder público através de políticas públicas que trabalhem aprofundadamente a discussão sobre violências.
Chemical Constituents of Snake Fruit (Salacca zalacca (Gaert.) Voss) Peel and in silico Anti-aging Analysis
Authors: Girsang Ermi , Lister I Nyoman Ehrich , Ginting Chrismis Novalinda , Khu Adrian , Samin Butter , Widowati Wahyu , Wibowo Satrio , Rizal Rizal
Published: September 2019

Background: Skin aging is a condition where skin is unable to retain both its physiological and structural integrity. Plants is the main source of phtytochemicals compound with wide range of biological activities. Through the efforts of ongoing scientific researches, an increasing number of plant extracts and phytochemicals have been showed promising result as anti-aging agent. Snake fruit (Salacca zalacca (Gaert.) Voss) is tropical plant belongs to the palm tree family (Arecaceae) that served as important crop in Indonesia. Despite its utilization, the phytochemical compound available in snake fruit, especially its peel have not been well documented. Present study aimed to elucidate the phytochemical constituent of snake fruit peel and its anti-aging potency.Materials and Methods: Snake fruit peel extract (SPE) was subjected to qualitative phytochemical assay, high performance liquid chromatography, and molecular docking towards protein related in skin aging.Results: The screening showed SPE contained phytochemical compound belong to flavonoid, tannin, phenol, triterpenoid, saponin and alkaloid. Thus, based on the analysis only chlorogenic acid was present in SPE whilst rutin and caffeic acid were not detected. The SPE was contained chlorogenic acid around 1.074 mg/g dry weight. Chlorogenic acid had the high binding affinity towards matrix metalloproteinase (MMP)-1 (-9.4 kcal/mol).Conclusion: Current findings may provide scientific evidence for possible usage of SPE and its compounds as antioxidant and anti-aging agent.Keywords: Salacca zalacca, phytochemical compound, high performance liquid chromatography, anti-aging
Application of self-evaluation and co-evaluation on learning processes
Authors: Vera Antonia Betty Gomez , Vera Mercedes Katherine Gomez , Garcia Aidee Monserrate Ramos , Miranda María Janeth Vélez
Published: September 2019

One of the important points within the evaluation is who performs it, long ago it was understood that the evaluation always came from an external instance to the evaluation, which was usually the teacher. Self-assessment is when the student is evaluated, while co-evaluation is when the group evaluates in a reciprocal way, encouraging participation, critical and constructive reflection, identifying achievements and shortcomings within the process of Learning. This article aimed to identify the application of self-assessment and co-evaluation in learning processes, where the research was of exploratory type, the scientific method was applied, synthetic analytical, gave as end result that teachers know the importance of these evaluative practices, because of situations of conformity, monotony, and fear of causing enmities with students do not use them.
Barriers and Facilitators to the Implementation of eHealth Services: Systematic Literature Analysis
Authors: Schreiweis Björn , Pobiruchin Monika , Strotbaum Veronika , Suleder Julian , Wiesner Martin , Bergh Björn
Published: September 2019

Background

The field of eHealth has a history of more than 20 years. During that time, many different eHealth services were developed. However, factors influencing the adoption of such services were seldom the main focus of analyses. For this reason, organizations adopting and implementing eHealth services seem not to be fully aware of the barriers and facilitators influencing the integration of eHealth services into routine care.

Objective

The objective of this work is to provide (1) a comprehensive list of relevant barriers to be considered and (2) a list of facilitators or success factors to help in planning and implementing successful eHealth services.

Methods

For this study, a twofold approach was applied. First, we gathered experts’ current opinions on facilitators and barriers in implementing eHealth services via expert discussions at two health informatics conferences held in Europe. Second, we conducted a systematic literature analysis concerning the barriers and facilitators for the implementation of eHealth services. Finally, we merged the results of the expert discussions with those of the systematic literature analysis.

Results

Both expert discussions (23 and 10 experts, respectively) identified 15 barriers and 31 facilitators, whereas 76 barriers and 268 facilitators were found in 38 of the initial 56 articles published from 12 different countries. For the analyzed publications, the count of distinct barriers reported ranged from 0 to 40 (mean 10.24, SD 8.87, median 8). Likewise, between 0 and 48 facilitators were mentioned in the literature (mean 9.18, SD 9.33, median 6). The combination of both sources resulted in 77 barriers and 292 facilitators for the adoption and implementation of eHealth services.

Conclusions

This work contributes a comprehensive list of barriers and facilitators for the implementation and adoption of eHealth services. Addressing barriers early, and leveraging facilitators during the implementation, can help create eHealth services that better meet the needs of users and provide higher benefits for patients and caregivers.
Pembuatan Sediaan Tabir Surya Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa), Aktivitas Inhibisi Fotodegradasi Tirosin dan Kandungan Fenolik Totalnya
Authors: Irianti Tatang , Sulaiman T. N. Syaifullah , Fakhrudin Nanang , Astuti Siluh , Testikawati Nita , Farida Sofa , Khasanah Sari Rosiati Nur
Published: September 2019

Senyawa fenolik mempunyai potensi sebagai fotoprotektor, sehingga mampu melindungi kulit dari kerusakan oksidatif terutama menyerap Ultra Violet dari pancaran sinar matahari. Ekstrak etanolik buah masak mahkota dewa [Phaleria macrocarpa (Scheff) Boerl.] mengandung senyawa fenolik dan memiliki peranan sebagai fotoprotektor. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanolik buah mahkota dewa sebagai fotoprotektor dalam sediaan tabir surya dan oksibenson sebagai pembanding. Aktivitas fotoprotektor ditentukan dari tingkat fotodegradasi tirosin dan kadar fenolik totalnya, kemudian penelitian ini dilakukan dengan 8 formula; formula 1 sebagai kontrol negatif (basis); formula 2 sebagai kontrol positif (basis dan oksibenson); formula 3, formula 4, dan formula 5 mengandung ekstrak etanolik buah mahkota dewa dengan berbagai konsentrasi; formula 6, formula 7, dan formula 8 mengandung oksibenson dan ekstrak etanolik buah mahkota dewa dengan berbagai konsentrasi. Penentuan kemampuan fotoproteksi berdasarkan persen transmisi eritema dan persen transmisi pigmentasi. Uji inhibisi fotodegradasi dilakukan dengan menggunakan enam kelompok komposisi tirosin dan Rhetoflam. Uji penentuan kadar fenolik total dilakukan menggunakan metode Follin-Ciocalteu. Hasil pengukuran diintrapolasikan ke dalam kurva baku asam galat. Ekstrak etanolik buah mahkota dewa dalam sediaan tabir surya memberikan nilai Te sebesar 17,86-37,01 % dan nilai Tp sebesar 12,07-22,64 %. Efektivitas fotoproteksi ekstrak etanolik buah mahkota dewa lebih kecil dibandingkan oksibenson yang memiliki nilai Te sebesar 1,15.10-5 % dan Tp sebesar 0,67 %. Kombinasi ekstrak etanolik buah mahkota dewa dan oksibenson memberikan nilai Te sebesar 0,17-0,52 % dan nilai Tp sebesar 2,10-4,48 %. Sedangkan kandungan fenolik total ekstrak buah mahkota dewa adalah sebesar 8,29 ± 0,27 % dengan aktivitas penghambatan fotodegradasi tirosin 1,58 kali lebih besar dibandingkan dengan vitamin C pada kadar yang sama, yaitu 0,15%. Hal ini menunjukkan bahwa ekstrak etanolik buah mahkota dewa dapat dimanfaatkan sebagai bahan 4aktif fotoprotektor dalam sediaan kosmetik.
Produksi dan Karakterisasi Gelatin dari Limbah Tulang Ayam dengan Menggunakan Spektrofotometer Ftir (Fourier Transform Infra Red)
Authors: Maryam St. , Effendi Nurmaya , Kasmah Kasmah
Published: September 2019

Gelatin merupakan protein hasil hidrolisis parsial kolagen tulang dan kulit. Gelatin memiliki sifat yang khas, yaitu dapat berubah secara reversible dari bentuk sol ke bantuk gel, mengembang dalam air dingin, dapat membentuk film serta mempengaruhi viskositas suatu bahan, dan melindungi sistem koloid. Penelitian ini bertujuan untuk mengetahui persen rendamen serta menentukan karakteristik proksimat dan fisikokimia dari gelatin tulang ayam. Penelitian ini dilakukan dengan metode eksperimental, proses yang dilakukan untuk menghasilkan gelatin melalui beberapa tahap yaitu degreasing, demineralisasi, ekstraksi dan pengeringan. Kemudian gelatin hasil ekstraksi dari keempat perlakuan tersebut dilakukan beberapa pengujian seperti karakteristik  proksimat  (kadar  air,  abu,  dan protein),  dan  karakteristik  fisikokimia  (pH dan viskositas) serta identifikasi gugus fungsi menggunakan spektrofotometri Fourier Transform Infra Red (FTIR). Hasil penelitian ini menunjukkan persen rendamen gelatin 1,030%, hasil karakterisasi proksimat yaitu kadar air 9,214%, kadar abu 10,396%, kadar protein 67,756% dan hasil karakteristik fisikokimia yaitu pH 6, viskositas relatif 6 cP. Berdasarkan spektra FTIR, gugus fungsi gelatin tulang ayam yang dapat diidentifikasi diantaranya adalah  gugus O-H, N-H, C-N, C=O & C-H. Dari hasil penelitian yang didapatkan dapat disimpulkan bahwa gelatin dari tulang ayam memenuhi standar mutu gelatin.
Pengaruh Home Pharmacy Care Terhadap Pengetahuan, Kepatuhan, Outcome Klinik Dan Kualitas Hidup Pasien Hipertensi
Authors: Widyastuti Sad , Yasin Nanang Munif , Kristina Susi Ari
Published: September 2019

Pengetahuan dan kepatuhan pengobatan yang rendah menjadi salah satu faktor yang berperan dalam tidak terkontrolnya hipertensi. Penelitian ini bertujuan untuk mengetahui pengaruh  home pharmacy care terhadap tingkat pengetahuan, kepatuhan, outcome klinik, dan kualitas hidup pasien hipertensi peserta Prolanis.Rancangan penelitian menggunakan kuasi ekperimental, dengan desain penelitian pretes-postes with control group. Bentuk home pharmacy care  berupa edukasi dan konseling  dengan alat bantu leaflet yang melibatkan pasien hipertensi peserta prolanis di Puskesmas Klaten yang masuk kriteria inklusi dan eksklusi. Instrumen yang digunakan adalah kuesioner HK-LS, ASRQ dan kuesioner SF-36. Untuk menganalisis antar variabel digunakan uji Mann-Withney.   Dari total 78 responden terbagi menjadi 39 kelompok kontrol dan 39 kelompok intervensi. Setelah dilakukan Intervensi home pharmacy care menunjukan bahwa kelompok intervensi memiliki nilai yang lebih baik dibandingkan dengan kelompok kontrol. Pada kelompok intervensi menunjukan ada peningkatan pengetahuan pasien dengan Δ3,2 dan (p=0,000), terjadi peningkatan kepatuhan dengan Δ-0,72 dan (p=0,000), terjadi penurunan tekanan darah sistolik dengan Δ–11,69 (p=0,000) dan Δ diastolik -7,56 dan (p=0,000) dan kualitas hidup pasien meningkat dengan nilai Δ2,17 nilai (p=0,001). Intervensi home pharmacy care memperbaiki semua aspek variabel yang diteliti dalam penelitian ini.