bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinicopathological differences in focal segmental glomerulosclerosis depending on the accompanying pathophysiological conditions in renal allografts
Authors: Taneda Sekiko , Honda Kazuho , Koike Junki , Ito Naoko , Ishida Hideki , Takagi Toshio , Nagashima Yoji
Published: November 2023

Primary focal segmental glomerulosclerosis (FSGS) is thought to be caused by circulating factors leading to podocytopathy, whereas segmental sclerotic lesions (FSGS lesions) have several causes. We studied the clinicopathological differences of FSGS-lesions in 258 cases of FSGS in renal allografts, depending on the following accompanying pathophysiology: recurrence of primary FSGS, calcineurin inhibitor (CNI)-induced arteriolopathy, antibody-mediated rejection (ABMR), and other conditions. All cases were categorized with the Columbia classification. Recurrent FSGS developed the earliest after transplantation and showed the highest percentage of the collapsing (COL) variant in which collapse of the glomerular capillaries with epithelial hypertrophy was apparent. FSGS accompanying CNI-induced arteriolopathy predominantly developed the not otherwise specified (NOS) variant, showing severe ultrastructural endothelial injury. On the contrary, approximately 7% of the cases showed the COL variant, presenting glomerular endothelial damage such as double contours of glomerular basement membrane and endothelial cell swelling as well as epithelial cell proliferation. FSGS with ABMR had the highest creatinine levels and cellular variant percentage, with marked inflammation and ultrastructural endothelial injury. Approximately two-thirds of the cases without ABMR, CNI-induced arteriopathy, or recurrent FSGS had other coexisting conditions such as glomerulonephritis, T cell-mediated rejection, and reflux nephropathy with progressive tubulointerstitial fibrosis. Most of these cases were of the NOS variant. The clinicopathologic features of post-transplant FSGS differed depending on the associated conditions, and endothelial injury was apparent especially in cases of CNI-induced arteriolopathy and ABMR. Precise observation of FSGS lesions may facilitate the diagnosis and clinical management of FSGS during renal transplantation.
Worldwide disparities in access to treatment and investigations for nephropathic cystinosis: a 2023 perspective
Authors: Regnier Maitena , Flammier Sacha , Boutaba Mounia , Ndongo Aliou Abdoulaye , Servais Aude , Schaefer Franz , Levtchenko Elena , Bacchetta Justine , Bertholet-Thomas Aurélia
Published: November 2023

Background

Nephropathic cystinosis (NC) is a rare lysosomal disease, leading to early kidney failure and extra-renal comorbidities. Its prognosis strongly relies on early diagnosis and treatment by cysteamine. Developing economies (DEing) face many challenges when treating patients for rare and chronic diseases. The aim here is to evaluate the access to investigations and treatment in DEing, and to assess for potential inequalities with Developed Economies (DEed).

Methods

In this international cross-sectional study, a questionnaire on access, price and reimbursement of genetic, biological analyses, and treatment was sent to nephrology centers worldwide during 2022.

Results

A total of 109 centers responded, coming from 49 countries and managing 741 patients: 43 centers from 30 DEing and Economies in transition (TrE), and 66 from 19 DEed. In 2022, genetics availability was 63% in DEing and 100% in DEed, whereas intra leukocytes cystine levels (IL-CL) were available for 30% of DEing patients, and 94% of DEed patients, both increasing over the last decade, as has access to immediate release cysteamine and to cysteamine eye drops in DEing. However, delayed released cysteamine can be delivered to only 7% vs. 74% of patients from DEing and DEed, respectively, and is still poorly reimbursed in DEing.

Conclusions

Over the last decade, access to investigations (namely genetics and IL-CL) and to cysteamine have improved in DEing and TrE. However, discrepancies remain with DEed: access to delayed released cysteamine is limited, and reimbursement is still profoundly insufficient, therefore limiting their current use.

Graphical abstract
Adsorption of some cationic dyes onto two models of graphene oxide
Authors: Mounra Emma , Malloum Alhadji , Fifen Jean Jules , Conradie Jeanet
Published: November 2023

Context:

The search for highly efficient adsorbent materials remains a significant requirement in the field of adsorption for wastewater treatment. Computational study can highly contribute to the identification of efficient material. In this work, we propose a computational approach to study the adsorption of four cationic basic dyes, basic blue 26 (BB26), basic green 1 (BG1), basic yellow 2 (BY2), and basic red 1 (BR1), onto two models of graphene oxide as adsorbents. The main objectives of this study are the assessment of the adsorption capacity of the graphene oxide towards basic dyes and the evaluation of the environmental and temperature effects on the adsorption capacity. Quantum theory of atoms in molecules (QTAIM) analysis has been used to understand the interactions between the dyes and graphene oxides. In addition, adsorption free energies of the dyes onto graphene oxides are calculated in gas and solvent phases for temperatures varying from 200 to 400 K. As a result, the adsorption free energy varies linearly depending on the temperature, highlighting the importance of temperature effects in the adsorption processes. Furthermore, the results indicate that the environment (through the solvation) considerably affects the calculated adsorption free energies. Overall, the results show that the two models of graphene oxide used in this work are efficient for removing dyes from wastewater.

Methods:

We have optimized the complexes formed by the interaction of dyes with graphene oxides at the PW6B95-D3/def2-SVP level of theory. The SMD solvation model realizes the implicit solvation, and water is used as the solvent. Calculations are performed using the Gaussian 16 suite of program. QTAIM analysis is performed using the AIMAll program. Gibbs free energies as function of temperature are calculated using the TEMPO program.
“Listen to us”: small-scale farmers’ understandings of social-ecological changes and their drivers in Important Agricultural Heritage Systems
Authors: Caviedes Julián , Ibarra José Tomás , Calvet-Mir Laura , Junqueira André Braga
Published: November 2023

Current social-ecological changes affect territories and people’s livelihoods worldwide. Many of these changes have detrimental effects on small-scale agricultural systems, with concomitant negative consequences on global and local food security and sovereignty. The objectives of this study were to explore (i) local knowledge on social-ecological changes and (ii) the perceived drivers of those changes occurring in a mountainscape and an islandscape in two Important Agricultural Heritage Systems of southern South America, both located within a Global Biodiversity Hotspot. This was done by conducting in-depth semi-structured interviews with local campesinos, whose livelihoods are based on the use and management of agrosilvopastoral systems. We found that local communities experience a wide range of globally and locally induced social-ecological changes acting in their territories. Campesinos mentioned 79 different observations of social-ecological changes and identified drivers for 77% of them. Changes in the atmospheric system, specifically regarding changes in precipitation, drought, and temperatures, were commonly observed by campesinos in both sites. Participants also observed complex interrelations between these changes and the drivers influencing them, climatic drivers being the most important. Even though general changes in climatic patterns were identified as drivers of changes by campesinos, other situated changes derived from the site’s biophysical, social, and economic conditions were also important. Our results highlight the importance of considering local knowledge to understand social-ecological changes and to support the development and implementation of public policies that promote contextualized adaptation measures to global changes that affect local livelihoods.
Clinical and imaging features of lymphomatosis cerebri: analysis of 8 cases and systematic review of the literature
Authors: Fan Mengke , Zhao Lu , Chen Qingjiang , Zhang Mingzhi , Zhang Xudong , Yang Zhihao , Li Suxiao , Song Yunfei
Published: November 2023

Lymphomatosis cerebri (LC) is a rare type of primary central nervous system lymphoma with diffuse, nonenhancing infiltrative lesions and is often misdiagnosed. Our study aimed to investigate the clinical characteristics and prognosis of LC through analyzing patients from the literature and our own center, so as to improve early diagnosis and treatment. PubMed, Web of Science and our hospital databases were reviewed, and information on demographic, clinical, pathological, cerebrospinal fluid (CSF), neuroimaging and treatment options was extracted. Univariate survival analysis was conducted by generating survival curves and comparing them using the log-rank test. Multivariate analysis was performed using the Cox proportional hazards regression model to identify the prognostic predictors. A total of 81 patients (median age: 58 years; interquartile range, IQR: 50–66.5 years), 45 males and 36 females, were included. The most common symptoms were cognitive impairment (65.4%) and gait impairment (50.6%). Imaging studies indicated that all 81 patients had supratentorial structure involvement, and 93.8% (76/81) had bilateral hemisphere involvement. There were 53.3% (32/60) patients with CSF pleocytosis and 65% (39/60) patients with increased CSF protein levels. The median time of diagnosis was 4.8 months (IQR: 2.3–6.9 months). Compared with 4 (95% CI: 1.78–6.22) months for all 81 patients, the median OS was 20 (95% CI: 8.24–31.76) months for those who had chemotherapy plus radiotherapy. Multivariate Cox analysis revealed that chemoradiotherapy (HR: 0.12; 95% CI: 0.02–0.68) and higher CSF glucose level (HR: 0.01; 95% CI: 0.00–0.26) were inversely associated with death. The diagnosis of LC should be alerted when neuroimaging with bilateral hemispheric involvement and CSF abnormality with pleocytosis and increased protein. Once the diagnosis is confirmed, the combination of chemotherapy and radiotherapy can be considered if the patient’s physical condition permits.Journal standard instruction requires an unstructured abstract. Kindly check and confirm.We have checked and confirmed that there is no problem.
Convolutional neural networks for accurate identification of mining remains from UAV-derived images
Authors: Fernández-Alonso Daniel , Fernández-Lozano Javier , García-Ordás María Teresa
Published: November 2023

A new deep learning system is proposed for the rapid and accurate identification of anthropogenic elements of the Roman mining infrastructure in NW Iberia, providing a new approach for automatic recognition of different mining elements without the need for human intervention or implicit subjectivity. The recognition of archaeological and other abandoned mining elements provides an optimal test case for decision-making and management in a broad variety of research fields. A new image dataset was created by obtaining UAV images from different anthropic features. A convolutional neural network architecture was implemented, achieving recognition results of close to 95% accuracy. This methodological approach is suitable for the identification and accurate location of ancient mines and hydrologic infrastructure, providing new tools for accurate mapping of mining landforms. Additionally, this novel application of deep learning can be implemented to reduce potential risks caused by abandoned mines, which can cause significant annual human and economic losses worldwide.
Be Well™ Acres Homes: a community-driven, evidence-based approach to reduce health inequities through sustained cross-sector partnership
Authors: Rechis Ruth , Oestman Katherine B. , Walsh Michael T. , Love Brad , Hawk Ernest
Published: November 2023

Purpose

Be Well Communities™ is MD Anderson’s signature place-based approach for cancer prevention and control, working with communities to promote wellness and address modifiable risk factors for cancer. The purpose of this paper is to describe implementation of the planning phase of the Be Well Communities model in Acres Homes which began in 2019.

Methods

A community advisory group (Steering Committee) including residents, non-profit organizations, health care partners, city and county agencies, plus other stakeholders, was convened and aligned through a structured process to develop shared goals, foster multisector collaboration, as measured by a stakeholder survey administered twice, and enhance community capacity to improve health outcomes through development of a Community Action Plan.

Results

Clear, achievable goals were developed, multisector collaboration was enhanced, and more than 400 h of capacity building support led to a Community Action Plan initially focused on healthy eating and active living, including 15 evidence-based interventions led by 18 organizations. The majority (93%) of the Steering Committee reports that this plan reflects community priorities and will reach the residents most in need.

Conclusion

By listening and developing trust, the Be Well Communities team successfully worked with Acres Homes residents and organizations to enhance community capacity to address health inequities in one of Houston’s most diverse and historic communities.
Navigating the metric maze: a taxonomy of evaluation metrics for anomaly detection in time series
Authors: Sørbø Sondre , Ruocco Massimiliano
Published: November 2023

The field of time series anomaly detection is constantly advancing, with several methods available, making it a challenge to determine the most appropriate method for a specific domain. The evaluation of these methods is facilitated by the use of metrics, which vary widely in their properties. Despite the existence of new evaluation metrics, there is limited agreement on which metrics are best suited for specific scenarios and domains, and the most commonly used metrics have faced criticism in the literature. This paper provides a comprehensive overview of the metrics used for the evaluation of time series anomaly detection methods, and also defines a taxonomy of these based on how they are calculated. By defining a set of properties for evaluation metrics and a set of specific case studies and experiments, twenty metrics are analyzed and discussed in detail, highlighting the unique suitability of each for specific tasks. Through extensive experimentation and analysis, this paper argues that the choice of evaluation metric must be made with care, taking into account the specific requirements of the task at hand.
Fast Kötter–Nielsen–Høholdt interpolation over skew polynomial rings and its application in coding theory
Authors: Bartz Hannes , Jerkovits Thomas , Rosenkilde Johan
Published: November 2023

Skew polynomials are a class of non-commutative polynomials that have several applications in computer science, coding theory and cryptography. In particular, skew polynomials can be used to construct and decode evaluation codes in several metrics, like e.g. the Hamming, rank, sum-rank and skew metric. We propose a fast divide-and-conquer variant of Kötter–Nielsen–Høholdt (KNH) interpolation algorithm: it inputs a list of linear functionals on skew polynomial vectors, and outputs a reduced Gröbner basis of their kernel intersection. We show, that the proposed KNH interpolation can be used to solve the interpolation step of interpolation-based decoding of interleaved Gabidulin codes in the rank-metric, linearized Reed–Solomon codes in the sum-rank metric and skew Reed–Solomon codes in the skew metric requiring at most $${\widetilde{O}}\left( s^\omega {\mathfrak {M}}(n)\right) $$

O
~

s
ω

M

(
n
)

operations in $${\mathbb {F}}_{q^m}$$

F

q
m

, where n is the length of the code, $$s$$
s
the interleaving order, $${\mathfrak {M}}(n)$$

M
(
n
)

the complexity for multiplying two skew polynomials of degree at most n, $$\omega $$
ω
the matrix multiplication exponent and $${\widetilde{O}}\left( \cdot \right) $$

O
~

·

the soft-O notation which neglects log factors. This matches the previous best speeds for these tasks, which were obtained by top–down minimal approximant bases techniques, and complements the theory of efficient interpolation over free skew polynomial modules by the bottom-up KNH approach. In contrast to the top–down approach the bottom-up KNH algorithm has no requirements on the interpolation points and thus does not require any pre-processing.
Thermal properties and the decomposition path of novel UV polymers of terpene-based monomer: citronellyl methacrylate
Authors: Makowskaya Katsiaryna , Jargieło Patrycja , Worzakowska Marta , Rogulska Magdalena
Published: November 2023

Thermal properties and the decomposition path of more environmentally friendly polymers in both atmospheres: inert and oxidizing have been studied with a use of simultaneous TG/FTIR/QMS and DSC methods. The polymeric materials in the UV-polymerization process of cyclohexyl methacrylate and methacrylate monomer obtained from natural terpene alcohol: citronellol, using different compositions of monomers were prepared. The glass transition temperature (Tg) and thermal stability of these high solvent and chemical resistant materials were dependent on the composition and increased with increasing cyclic monomer content in the compositions. The Tg changed from 9.8˚C to 47.5˚C and a thermal stability from 195˚C to 222˚C (inert atmosphere) and from 160˚C to 217˚C (oxidizing atmosphere). The TG/FTIR/QMS analysis proved the emission of cyclohexyl methacrylate, citronellyl methacrylate and their lower molecular mass decomposition fragments, e.g., propene, cyclohexane, citronellol, citronellal, formic acid, methacrylic acid and CO, CO2 during heating of these materials in helium and air atmospheres. It indicated the same radical mechanism of their decomposition in both atmospheres which meant that the presence of oxygen did not affect the course of decomposition but reduced the initial decomposition temperature of the copolymers.
What do we know about the disruption index in scientometrics? An overview of the literature
Authors: Leibel Christian , Bornmann Lutz
Published: November 2023

The purpose of this paper is to provide a review of the literature on the original disruption index (DI1) and its variants in scientometrics. The DI1 has received much media attention and prompted a public debate about science policy implications, since a study published in Nature found that papers in all disciplines and patents are becoming less disruptive over time. This review explains in the first part the DI1 and its variants in detail by examining their technical and theoretical properties. The remaining parts of the review are devoted to studies that examine the validity and the limitations of the indices. Particular focus is placed on (1) possible biases that affect disruption indices (2) the convergent and predictive validity of disruption scores, and (3) the comparative performance of the DI1 and its variants. The review shows that, while the literature on convergent validity is not entirely conclusive, it is clear that some modified index variants, in particular DI5, show higher degrees of convergent validity than DI1. The literature draws attention to the fact that (some) disruption indices suffer from inconsistency, time-sensitive biases, and several data-induced biases. The limitations of disruption indices are highlighted and best practice guidelines are provided. The review encourages users of the index to inform about the variety of DI1 variants and to apply the most appropriate variant. More research on the validity of disruption scores as well as a more precise understanding of disruption as a theoretical construct is needed before the indices can be used in the research evaluation practice.
Prevention and control of ship-source pollution in the Arctic shipping routes: challenges and countermeasures
Authors: Zhang Cheng , Yang Jia-qi
Published: November 2023

Ship-source pollution is one of the important contributors to marine environment pollution. Because the legal status of the Arctic shipping routes is not clear, there is a considerable degree of dispute in the application of the rules on the prevention and control of ship-source pollution. The increased melting of sea ice undermines the legal legitimacy of the “ice-covered areas” clause under the United Nations Convention on the Law of the Sea. The conflict between the application of the Polar Code and “ice-covered areas” will also reach an initial conclusion in the context of melting sea ice. However, the inadequacy of ship-source pollution rules in the Polar Code hampers its application, which has led to a negative impact on the more active role in the governance of pollution from Arctic shipping. For replying to the Challenges in the prevention of ship-source pollution in Arctic shipping routes, the relevant rules of the Polar Code need to be further improved, while a more binding HFO ban according to ship types needs to be applied. Therefore, a more important role in the future Arctic governance mechanism will be played by the enhanced enforcement of the Polar Code, meanwhile, the target for uniform international regulation of preventing and controlling ship-source pollution in Arctic shipping routes should be achieved.
Changing trends in gamma knife surgery to linear accelerator brain stereotactic radiotherapy in Japan: a survey based on the nationwide claims database
Authors: Koide Yutaro , Aoyama Takahiro , Tanaka Hiroshi , Shindo Yurika , Nagai Naoya , Kitagawa Tomoki , Shimizu Hidetoshi , Hashimoto Shingo , Tachibana Hiroyuki , Kodaira Takeshi
Published: November 2023

Purpose

This study evaluated the trends in the platform for stereotactic radiotherapy to the brain (SRT), utilizing the open data of the National Database published by the Ministry of Health, Labour, and Welfare.

Materials and methods

This study analyzed data from FY2014 to FY2021. The practices included in the study were gamma knife surgery (GKS) and SRT with a linear accelerator (LINAC). The total number of outpatient and inpatient cases in each SRT system was evaluated annually.

Results

From April 2014 to March 2022, the study included 212,016 cases (102,691 GKS and 109,325 LINAC) of the registered 1,996,540 radiotherapy cases. In the first year, 13,117 (54.1%) cases were GKS, and 11,128 (45.9%) were LINAC; after that, GKS decreased, and LINAC increased, reaching the same rate in FY2017. Compared to the first year, the final year showed 11,702 GKS (− 1415 or − 10.8%) and 17,169 LINAC (+ 6041 or + 54.3%), with an increase of 4626 total SRT cases to 28,871 (+ 19.1%). The percentage of outpatient treatment also increased from 4.6 to 11.8% for GKS and from 44.7 to 57.9% for LINAC.

Conclusion

The study found a gradual decrease in the selection of GKS, an increasing trend in the selection of LINAC, and an increase in the overall number of stereotactic irradiations. In particular, the proportion of outpatient treatment increased, indicating that more than half of LINAC was selected for outpatient treatment.
“Don’t Leave me Behind!” Problematic Internet Use and Fear of Missing Out Through the Lens of Epistemic Trust in Emerging Adulthood
Authors: Benzi Ilaria Maria Antonietta , Fontana Andrea , Lingiardi Vittorio , Parolin Laura , Carone Nicola
Published: November 2023

The present study investigates the association between Fear of Missing Out (FoMO) and Problematic Internet Use (PIU) in a sample of 358 cisgender emerging adults (74.58% females assigned at birth; Mage = 25.02, SD = 2.60; age range: 18–29 years), with a specific focus on the roles of various stances of Epistemic Trust, including Trust, Mistrust, and Credulity. The aim is to explore the complexities of these relationships and their implications for the psychological well-being of this population. We computed a mediation model to examine the relationships among PIU as the dependent variable, FoMO as the predictor, and Epistemic Trust, Mistrust, and Credulity as the mediating factors. Covariates such as age, gender, and sexual orientation were also considered in the analysis. The results revealed significant indirect effects for both Mistrust and Credulity. Specifically, higher levels of FoMO were associated with increased Mistrust and Credulity, leading to greater PIU. In contrast, the indirect effect of Trust was not significant. Also, FoMO had a direct effect on PIU. The results highlight the importance of considering Mistrust and Credulity as potential risk factors for Internet addiction in emerging adults. These findings have practical implications for clinical practice, psychological assessment, and intervention strategies, emphasizing the need to address FoMO and its associated vulnerabilities within different therapeutic settings. By doing so, mental health professionals can better support the psychological well-being of emerging adults and assist them in navigating the challenges inherent to this crucial developmental stage.
Does habitual moderate alcohol consumption enhance working memory performance?
Authors: Cansino Selene , Torres-Trejo Frine , Estrada-Manilla Cinthya , Ruiz-Velasco Silvia
Published: November 2023

The present study aimed to establish whether habitual alcohol consumption benefits verbal and spatial working memory performance after addressing the main criticisms that have been raised against the finding that alcohol benefits cognition. An adult lifespan sample of 1,652 healthy adults between 21 and 80 years of age participated in the study. Participants were classified as lifetime nondrinkers or drinkers, and several demographic and biological variables were controlled. Alcohol consumption was assessed through a lifestyle questionnaire created for the study. Working memory was measured through a 2-back computerized task. Discrimination and speed in verbal and spatial working memory among drinkers were superior to those among nondrinkers. Total alcohol intake across life and the amount of alcohol intake per week predicted higher verbal and spatial working memory discrimination. Beer drinkers showed more accurate and faster responses in verbal and spatial working memory than nondrinkers, wine drinkers and spirit drinkers. The optimal amount of alcohol intake to benefit working memory for women and men was 100 g per week, which is equivalent to one drink per day. After consuming 350 g of alcohol per week, equivalent to 25 drinks per week, the effects of alcohol on working memory become more negative than the effects of alcohol abstinence. While alcohol consumption is considered a risk factor for several diseases, we found that moderate alcohol intake benefits working memory performance throughout the adult lifespan to a greater extent than whole-life abstinence.
Why are the Solutions to Overdetermined Problems Usually “As Symmetric as Possible”?
Authors: Cavallina Lorenzo
Published: November 2023

In this paper, we study the symmetry properties of nondegenerate critical points of shape functionals using the implicit function theorem. We show that, if a shape functional is invariant with respect to some one-parameter group of rotations, then its nondegenerate critical points (bounded open sets with smooth enough boundary) share the same symmetries. We also consider the case where the shape functional exhibits translational invariance in addition to just rotational invariance. Finally, we study the applications of this result to the theory of one/two-phase overdetermined problems of Serrin-type. En passant, we give a simple proof of the fact that, under suitable smoothness assumptions, the ball is the only nondegenerate critical point of the Lagrangian associated to the maximization problem for the torsional rigidity under a volume constraint. We remark that the proof does not rely on either the method of moving planes or rearrangement techniques.
Assessing the Verbal Behavior of a Linguistically Diverse Speaker with Autism
Authors: Atherkode Sreeja , Mason Lee
Published: November 2023

For speakers belonging to multiple verbal communities, functional analyses of verbal behavior allow for dynamic control over response topography. The simple practice of allowing the speaker the freedom to select the language of instruction minimizes cultural bias and hegemony. We extended the research on functional analyses of verbal behavior to include a speaker of multiple languages in a quasi-experimental case study. We employed verbal operant experimental (VOX) analyses as a repeated measure of language acquisition with a linguistically diverse, 7-year-old Indian boy with autism. The VOX analyses were conducted as part of the child’s early intensive behavioral intervention, and we observed the impact of an immersive foreign language experience on his verbal repertoire with follow-up VOX analyses conducted in three topographically distinct languages: English, Telugu, and Tamil. The results show a dynamic hierarchy of strength between the three languages, with overarching patterns across the three assessments. The implications for using VOX analyses to assess the functional language skills of multilingual speakers with autism are discussed, and areas of future research are highlighted.
Meaningfulness, Death, and Suffering: Philosophy of Meaning in Life in the Light of Finitude
Authors: Peltomäki Isto Johannes
Published: November 2023

Subjective sense of meaningfulness of life, or meaning in life, is a growing theme of interest in psychological research. Psychology of meaningfulness originates from existential psychology that aligned closely to mid-twentieth century philosophical existentialism. Now positive psychology is a strong field of study of meaning in life. This article investigates the role of the negative element of human life, that is, death and suffering, plays in psychologies about meaning in life. This article proposes the concept of finitude for the negative element of human life, aims to clarify the central concepts of meaning in life and meaning-making, and offers a short intellectual historical background on questioning existential psychology and meaning in life. The article concentrates on selected classic existential psychological thinkers (Viktor Frankl, Rollo May, and Irvin Yalom), on Tatjana Schnell’s contemporary existential psychology, and on Martin Seligman’s contemporary positive psychology.
Assessing the potential of compaction techniques in tropical peatlands for effective carbon reduction and climate change mitigation
Authors: Samuel Marshall Kana , Evers Stephanie L.
Published: November 2023

There is a pressing need to tackle carbon emissions from oil palm plantations on tropical peatland, which has garnered significant discussion and concern in recent years. In response, compaction techniques were introduced in Malaysia with the aim of mitigating CO2 emissions by improving moisture levels and reducing soil aeration. This research investigates the impact of mechanical compaction on two distinct ecosystems: a peat swamp forest (PSF) and an oil palm plantation (OPP), characterized by their unique physicochemical properties Using a specially designed compaction apparatus, significant changes in carbon emissions were observed in PSF but not in OPP, with means 1263 and 404 mg CO2-eq m−2 h−1, respectively. This disparity can be due to substrate availability between the two ecosystems. Subsequently, in the PSF, a promising pattern of a percentage ratio of approximately 1:3.5 was observed, indicating a substantial reduction in CO2 emissions (from 1295 to 468 mg m−2 h−1; 64%) alongside a corresponding increase in CH4 emissions (from −50 to 60 µg m−2 h−1; 221%). This finding suggests that compaction alters the aerobic peat horizon, bringing the peat surface closer to the groundwater level. The study underscores the importance of considering confounding factors such as decomposition degree and groundwater fluctuation when assessing the effects of compaction on tropical peat. By shedding light on these complexities, the findings contribute to a better understanding of the efficacy of compaction techniques in reducing emissions of these special case atmospheric pollutants.
An antenna array utilizing slotted conductive slab: inspired by metasurface and defected ground plane techniques for flexible electronics and sensors operating in the millimeter-wave and terahertz spectrum
Authors: Ali Esraa Mousa , Alibakhshikenari Mohammad , Virdee Bal S. , Kouhalvandi Lida , Livreri Patrizia , Falcone Francisco
Published: November 2023

This paper describes an innovative design of an antenna array that is metamaterial inspired using sub-wavelength slots and defected ground structure (DGS) for operation over millimeter-wave and terahertz (THz) spectrum. The proposed antenna array consists of a 2 × 4 array of conductive boxes on which are implemented rectangular slots. The presence of dielectric slots introduces resonant modes within the structure. These resonant modes result in enhancing the electromagnetic fields within the slots, which radiate energy into free space. The resonant frequencies and radiation patterns depend on the specific geometry of the slots and the dielectric properties. The antenna array is excited through a single microstrip line. The radiating elements in the array are interconnected to each other with a microstrip line. Unwanted mutual coupling between the radiating elements can degrade the performance of the antenna. This was mitigated by defecting the ground plane with rectangular slots. It is shown that this technique can enhance the array’s reflection coefficient over a wider bandwidth. The array was constructed on polyimide substrate having dielectric constant of 3.5 and thickness of 20 μm. The design was modelled, and its performance verified using an industry standard electromagnetic package by CST Studio Suite. The proposed array antenna has dimensions of 20 × 10 mm2 and operates between 80 and 200 GHz for radiation gain better than 4 dBi and efficiency above 55%. The peak radiation gain and efficiency are 7.5 dBi and 75% at 91 GHz, respectively. The operational frequency range of the array corresponds to a fractional bandwidth of 85.71%.
The effect of 10-week long yoga training on interoceptive abilities: cross-sectional and longitudinal investigation of cardiac and gastric accuracy
Authors: Koncz Ádám , Csala Barbara , Ferentzi Eszter
Published: November 2023

Based on their characteristics, it is likely that mind–body techniques develop interoception, the perception of bodily state. Nevertheless, findings on mindfulness, meditation, yoga, and body scan techniques are inconclusive. Additionally, the methodological scope is not exhaustive, neither in terms of the intervention nor the applied measure of interoception. This study investigated for the first time the effect of regular yoga training on cardiac and gastric perceptual ability (measured with the mental heartbeat tracking task and the water load task, respectively). With the involvement of 90 female university students (yoga group n = 57, control group n = 33) we did not find any connection between baseline heartbeat perception score and gastric fullness. Moreover, the applied 10-week-long regular yoga training did not develop any of the measured interoceptive abilities. We conclude that yoga might develop other abilities than these specific sensations. Very probably, the measured cardiac and gastric perceptual abilities do not represent bodily sensations in general. It would be worth to investigate, however, the effect of longer yoga training on interoception.
Effect of Pb doping on the structural, optical and electrical properties of sol–gel ZnO nanoparticles
Authors: Moosavi Fatemeh , Neri Giovanni
Published: November 2023

Pure and Pb-doped ZnO NPs were synthesized using the sol–gel method. The structural and morphological properties were investigated via XRD, FTIR and FE-SEM. A detailed study of the effect of Pb on the properties of ZnO NPs ascertained many interesting results. XRD analysis showed that doped and undoped samples have hexagonal wurtzite structures and the average grain size increases from 21.2 to 27.8 nm with doping. Morphological analysis of undoped and Pb-doped ZnO NPs indicated that they are composed of quasi-spherical particles. Optical and electrical characteristics were also evaluated by UV–Vis spectroscopy and electrical measurements. These studies revealed that the Pb doping resulted in a blue shift of the absorption edge and thus increasing the gap band, from 3.39 to 3.53, and the electrical resistance. Based on these characteristics, the possible use of the sol–gel synthesized Pb–ZnO for conductometric gas sensing, was also discussed.
Principles of Turbomachinery in Air-Breathing Engines
Authors: Baskharone Erian A. , Hill D. Lee
Published: November 2023

Acquire complete knowledge of the basics of air-breathing turbomachinery with this hands-on practical text. This updated new edition for students in mechanical and aerospace engineering discusses the role of entropy in assessing machine performance, provides a review of flow structures, and includes an applied review of boundary layer principles. New coverage describes approaches used to smooth initial design geometry into a continuous flow path, the development of design methods associated with the flow over blade shape (cascades loss theory) and annular type flows, as well as a discussion of the mechanisms for the setting of shaft speed. This essential text is also fully supported by over 200 figures, numerous examples, and homework problems, many of which have been revised for this edition.
The History of Manchuria, 1840-1948
Authors: Nish Ian
Published: November 2023

In The History of Manchuria, 1840-1948, Ian Nish describes the turbulent times which the three Northeastern Provinces of China experienced in the last two centuries. The site of three serious wars in 1894, 1904 and 1919, the territory rarely enjoyed peace though its economy progressed because of the building of arterial railways. From 1932 it came under the rule of the Japanese-inspired government of Manchukuo based at Changchun. But that was short-lived, being brought to an end by the punitive incursion and occupation of the country by Soviet forces in 1945. Thereafter the devastated territory was fought over by Chinese Nationalist and Communist armies until Mukden (Shenyang) fell to the Communists in October 1948. Manchuria, under-populated but strategically important, was the location for disputes between China, Russia and Japan, the three powers making up the 'triangle' which gives the name to the sub-title of this study. These countries were hardly ever at peace with one another, the result being that the economic growth of a potentially wealthy country was seriously retarded. The story is illustrated by extracts drawn from contemporary documents of the three triangular powers.
A Unique Banchado
Authors: Young-woo Han
Published: November 2023

Fully illustrated in colour, here is the first introduction in English to one of Korea's outstanding cultural assets - the banchado ('painting of the order of guests at a royal event') - relating to all those taking part (1800 people) in the eight-day royal procession to Hwaseong (Gyeonggi Province) organized by King Jeongjo in 1795 for the dual purpose of visiting his father's tomb and celebrating his mother's sixtieth birthday. The banchado is a fine example of the meticulous record-keeping of the period (known as uigwe - the subject-matter of this book being known as the Wonhaeng eulmyo jeongni uigwe) and the skills of the court artists at that time. In addition to the banchado illustrations, the Wonhaeng eulmyo jeongni uigwe contains extensive lists of all the participants in the procession, details of the workers and technicians involved, including their duties and wages. It even includes the different foods offered at meal-times, the quantity of ingredients and the costs. The author provides a full analysis of the context, planning, execution and significance of the event.
The Fame of Sor Juana Inés de la Cruz
Authors: Echenberg Margo
Published: November 2023

The Fame of Sor Juana Inés de la Cruz traces the meteoric trajectory of the Mexican Tenth Muse's renown and studies how her worldly celebrity was altered posthumously by elegists in her Fama y obras póstumas [Fame and Posthumous Works] of 1700. In this study of a polyphonic, transatlantic volume, the didactic framework of early modern fame is pushed to its limits as panegyrists inscribe the nun into an evolving world-view that could trade in the fictions of the saintly exemplar, the Tenth Muse or a New World treasure, but could not preserve a woman's renown on the grounds of authorship. Only by making her legible could she vie for the promise of posthumous fame. In flushing out the machinations of Sor Juana's role as agent of her own celebrity as well as the negotiations of her contemporaries, this book opens new lines of inquiry in the study of early modern fame and print culture and the role of writers, panegyrists and editors as cultural agents in the transatlantic literary relationship between Mexico and Spain.
The Biography of a God
Authors: Sharabi Asaf
Published: November 2023

Mahasu is the joint name of four gods whose influence is widespread throughout the Indian states of Himachal Pradesh and Uttarakhand. Like other deities in the Western Himalayas, they are regarded as royal gods who rule over territories and people. This book traces changes in faith and practices surrounding the Mahasu brothers, and shows how the locals understand these changes by emphasizing the dominant role of humans in the decisions of the gods. The locals are also constantly testing the authenticity of the human mediumship. Thus, the book presents the claim that the gap between local conceptions of divinity and the perceptions of anthropologists regarding gods may be narrower than we think.

The Biography of a God: Mahasu in the Himalayas is based on ethnographic research, resulting in an important contribution to the study of Indian village deities, Himalayan Hinduism, lived Hinduism, and the anthropology of religion.
Optimizing Boundary Conditions in GNSS Tomography: A Continuous 7‐Month Case Study in the Amazon
Authors: Miranda P. M. A. , Adams D. K. , Tomé R. , Fernandes R. , Mateus P.
Published: November 2023

Different estimates of the regional water vapor scale height, taken from ERA5 reanalysis, in situ observations and the direct optimization of retrieved water vapor profiles in GNSS tomography, are found to have major impact in the performance of tomographic inversions, with the better results displaying mean errors comparable to radiosondes. The analysis uses 7 months of GNSS (Global Navigation Satellite Systems) observations in the Amazon Dense GNSS Network near Manaus, Brazil, in 2011–2012, to compute a time series of water vapor profiles, with a tomographic technique capable of producing quasi‐instantaneous inversions with minimal external data or constraints. Results compare very well with 12‐hourly in situ radiosondes, especially in the lower troposphere above 2 km, and its daily‐to‐seasonal variability compares well with WRF (Weather Research and Forecasting) convective‐permitting simulations driven by ERA5 boundary conditions, suggesting that GNSS tomography may be an important source of atmospheric water vapor data for different applications.
Crustal Conditions Favoring Convective Downward Migration of Fractures in Deep Hydrothermal Systems
Authors: Halldórsdóttir Sæunn , Berre Inga , Keilegavlen Eirik , Axelsson Gudni
Published: November 2023

Cooling magma plutons and intrusions are the heat sources for hydrothermal systems in volcanic settings. To explain system longevity and observed heat transfer at rates higher than those explained by pure conduction, the concept of fluid convection in fractures that deepen because of thermal rock contraction has been proposed as a heat‐source mechanism. While recent numerical studies have supported this half a century old hypothesis, understanding of the various regimes where convective downward migration of fractures can be an effective mechanism for heat transfer is lacking. Using a numerical model for fluid flow and fracture propagation in thermo‐poroelastic media, we investigate scenarios for which convective downward migration of fractures may occur. Our results support convective downward migration of fractures as a possible mechanism for development of hydrothermal systems, both for settings within active zones of volcanism and spreading and, under favorable conditions, in older crust away from such zones.
Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications
Authors: Sun Shicheng , Qi Guoliang , Chen Hao , He Dong , Ma Dengzhen , Bie Yifan , Xu Linzong , Feng Bin , Pang Qi , Guo Hua , Zhang Rui
Published: November 2023

Glioma, the most common primary malignant tumor of the central nervous system, lacks effective targeted therapies. This study investigates the role of SOAT1, a key gene involved in cholesterol esterification, in glioma prognosis and its association with ferroptosis. Although the impact of SOAT1 on glioma prognosis has been recognized, its precise mechanism remains unclear. In this study, we demonstrate that inhibiting SOAT1 increases the sensitivity of glioma cells to ferroptosis, both in vitro and in vivo. Mechanistically, SOAT1 positively modulates the expression of SLC40A1, an iron transporter, resulting in enhanced intracellular iron outflow, reduced intracellular iron levels, and subsequent disruption of ferroptosis. Importantly, we find that SOAT1 regulates ferroptosis independently of SREBPs, which are known to be involved in ferroptosis regulation. Furthermore, we identify the involvement of the PI3K-AKT-mTOR signaling pathway in mediating the regulatory effects of SOAT1 on SLC40A1 expression and ferroptosis sensitivity. These findings highlight the contribution of intracellular signaling cascades in the modulation of ferroptosis by SOAT1. We show that inhibiting SOAT1 enhances the efficacy of radiotherapy in gliomas, both in vitro and in vivo, by promoting sensitivity to ferroptosis. This suggests that targeting SOAT1 could potentially improve therapeutic outcomes for glioma patients. In summary, this study uncovers the pivotal role of SOAT1 as a link between cholesterol esterification and ferroptosis in glioma. Our findings underscore the potential of SOAT1 as a promising clinical therapeutic target, providing new avenues for the development of effective treatments for glioma. Further research is warranted to unravel the complete regulatory mechanisms of SOAT1 and explore its clinical applications.