bluuebunny/crossref_metadata_2025 huggingface dataset:
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4
Authors: Salsman Jayme , Stathakis Alex , Parker Ellen , Chung Dudley , Anthes Livia E. , Koskowich Kara L. , Lahsaee Sara , Gaston Daniel , Kukurba Kimberly R. , Smith Kevin S. , Chute Ian C. , Léger Daniel , Frost Laura D. , Montgomery Stephen B. , Lewis Stephen M. , Eskiw Christopher , Dellaire Graham
Published: March 2017

The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes in the vicinity of these bodies. However, few PML NB-associated genes have been identified. PML and PML NBs can also regulate mTOR and cell fate decisions in response to cellular stresses. We now demonstrate that PML depletion in U2OS cells or TERT-immortalized normal human diploid fibroblasts results in decreased expression of the mTOR inhibitor DDIT4 (REDD1). DNA and RNA immuno-FISH reveal that PML NBs are closely associated with actively transcribed DDIT4 loci, implicating these bodies in regulation of basal DDIT4 expression. Although PML silencing did reduce the sensitivity of U2OS cells to metabolic stress induced by metformin, PML loss did not inhibit the upregulation of DDIT4 in response to metformin, hypoxia-like (CoCl2) or genotoxic stress. Analysis of publicly available cancer data also revealed a significant correlation between PML and DDIT4 expression in several cancer types (e.g. lung, breast, prostate). Thus, these findings uncover a novel mechanism by which PML loss may contribute to mTOR activation and cancer progression via dysregulation of basal DDIT4 gene expression.
Multiparty Quantum Key Agreement Based on Quantum Search Algorithm
Authors: Cao Hao , Ma Wenping
Published: March 2017

Quantum key agreement is an important topic that the shared key must be negotiated equally by all participants, and any nontrivial subset of participants cannot fully determine the shared key. To date, the embed modes of subkey in all the previously proposed quantum key agreement protocols are based on either BB84 or entangled states. The research of the quantum key agreement protocol based on quantum search algorithms is still blank. In this paper, on the basis of investigating the properties of quantum search algorithms, we propose the first quantum key agreement protocol whose embed mode of subkey is based on a quantum search algorithm known as Grover’s algorithm. A novel example of protocols with 5 – party is presented. The efficiency analysis shows that our protocol is prior to existing MQKA protocols. Furthermore it is secure against both external attack and internal attacks.
Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia
Authors: Matsumoto Junya , Nakanishi Hiroki , Kunii Yasuto , Sugiura Yuki , Yuki Dai , Wada Akira , Hino Mizuki , Niwa Shin-Ichi , Kondo Takeshi , Waki Michihiko , Hayasaka Takahiro , Masaki Noritaka , Akatsu Hiroyasu , Hashizume Yoshio , Yamamoto Sakon , Sato Shinji , Sasaki Takehiko , Setou Mitsutoshi , Yabe Hirooki
Published: March 2017

The etiology of schizophrenia includes phospholipid abnormalities. Phospholipids are bioactive substances essential for brain function. To analyze differences in the quantity and types of phospholipids present in the brain tissue of patients with schizophrenia, we performed a global analysis of phospholipids in multiple brain samples using liquid chromatography electrospray ionization mass/mass spectrometry (LC-ESI/MS/MS) and imaging mass spectrometry (IMS). We found significantly decreased 16:0/20:4-phosphatidylinositol (PI) levels in the prefrontal cortex (PFC) in the brains from patients with schizophrenia in the LC-ESI/MS/MS, and that the 16:0/20:4-PI in grey matter was most prominently diminished according to the IMS experiments. Previous reports investigating PI pathology of schizophrenia did not identify differences in the sn-1 and sn-2 fatty acyl chains. This study is the first to clear the fatty acid composition of PI in brains from patients with schizophrenia. Alteration in the characteristic fatty acid composition of PI may also affect neuronal function, and could play a role in the etiology of schizophrenia. Although further studies are necessary to understand the role of reduced 16:0/20:4-PI levels within the prefrontal cortex in the etiology of schizophrenia, our results provide insight into the development of a novel therapy for the clinical treatment of schizophrenia.
The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme
Authors: Torraca Vincenzo , Tulotta Claudia , Snaar-Jagalska B. Ewa , Meijer Annemarie H.
Published: March 2017

CXC chemokine receptor 4 plays a critical role in chemotaxis and leukocyte differentiation. Furthermore, there is increasing evidence that links this receptor to angiogenesis. Using the well-established zebrafish-Mycobacterium marinum model for tuberculosis, angiogenesis was recently found to be important for the development of cellular aggregates called granulomas that contain the mycobacteria and are the hallmark of tuberculosis disease. Here, we found that initiation of the granuloma-associated proangiogenic programme requires CXCR4 signalling. The nascent granulomas in cxcr4b-deficient zebrafish embryos were poorly vascularised, which in turn also delayed bacterial growth. Suppressed infection expansion in cxcr4b mutants could not be attributed to an overall deficient recruitment of leukocytes or to different intramacrophage bacterial growth rate, as cxcr4b mutants displayed similar microbicidal capabilities against initial mycobacterial infection and the cellular composition of granulomatous lesions was similar to wildtype siblings. Expression of vegfaa was upregulated to a similar extent in cxcr4b mutants and wildtypes, suggesting that the granuloma vascularisation phenotype of cxcr4b mutants is independent of vascular endothelial growth factor.
Metabolic Flux Redirection and Transcriptomic Reprogramming in the Albino Tea Cultivar ‘Yu-Jin-Xiang’ with an Emphasis on Catechin Production
Authors: Liu Guo-Feng , Han Zhuo-Xiao , Feng Lin , Gao Li-Ping , Gao Ming-Jun , Gruber Margaret Y. , Zhang Zhao-Liang , Xia Tao , Wan Xiao-Chun , Wei Shu
Published: March 2017

In this study, shade-induced conversion from a young pale/yellow leaf phenotype to a green leaf phenotype was studied using metabolic and transcriptomic profiling and the albino cultivar ‘Yu-Jin-Xiang’ (‘YJX’) ofCamellia sinensisfor a better understanding of mechanisms underlying the phenotype shift and the altered catechin and theanine production. Shaded leaf greening resulted from an increase in leaf chlorophyll and carotenoid abundance and chloroplast development. A total of 1,196 differentially expressed genes (DEGs) were identified between the ‘YJX’ pale and shaded green leaves, and these DEGs affected ‘chloroplast organization’ and ‘response to high light’ besides many other biological processes and pathways. Metabolic flux redirection and transcriptomic reprogramming were found in flavonoid and carotenoid pathways of the ‘YJX’ pale leaves and shaded green leaves to different extents compared to the green cultivar ‘Shu-Cha-Zao’. Enhanced production of the antioxidant quercetin rather than catechin biosynthesis was correlated positively with the enhanced transcription ofFLAVONOL SYNTHASEandFLAVANONE/FLAVONOL HYDROXYLASESleading to quercetin accumulation and negatively correlated to suppressedLEUCOANTHOCYANIDIN REDUCTASE, ANTHOCYANIDIN REDUCTASEandSYNTHASEleading to catechin biosynthesis. The altered levels of quercetin and catechins in ‘YJX’ will impact on its tea flavor and health benefits.
Retinol Binding Protein-4 Levels and Non-alcoholic Fatty Liver Disease: A community-based cross-sectional study
Authors: Chen Xuechen , Shen Tianran , Li Qing , Chen Xu , Li Yanping , Li Dan , Chen Gengdong , Ling Wenhua , Chen Yu-ming
Published: March 2017

Previous reports on the association between retinol binding protein 4 (RBP4) and nonalcoholic fatty liver disease (NAFLD) were controversial. This study aimed to investigate the association between the serum RBP4 levels and occurrence of NAFLD in Chinese population. In total, 2938 participants aged 40–75 years were involved in this community-based cross-sectional study. General information, lifestyle factors, serum levels of RBP4 and the presence of NAFLD were determined. Patients with NAFLD had significantly higher concentrations of RBP4 (37.9 ± 6.8 μg/ml) than did non-NAFLD controls (35.0 ± 6.7 μg/ml) (P < 0.001). The odds ratios (ORs) of NAFLD for the highest (vs. lowest) quartile of RBP4 were 1.884 (95% CI: 1.391, 2.551) for females (P < 0.001), and 2.107 (95% CI: 1.357, 3.273) for male participants (P < 0.01) after adjusting for related factors. The serum RBP4 levels were positively associated with the prevalence of NAFLD in middle-aged and elderly Chinese people, and Homeostatic model assessment-insulin resistance (HOMA-IR), trunk fat, the waist-to-hip ratio (WHR), systolic blood pressure (SBP), fasting insulin, high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) might be implicated in the pathogenesis of RBP4 in NAFLD.
Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients
Authors: Nomizo Takashi , Ozasa Hiroaki , Tsuji Takahiro , Funazo Tomoko , Yasuda Yuto , Yoshida Hironori , Yagi Yoshitaka , Sakamori Yuichi , Nagai Hiroki , Hirai Toyohiro , Kim Young Hak
Published: March 2017

This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We investigated the association among PD-1/PD-L1 SNPs, objective response rate (ORR) and progression-free survival (PFS). Two of seven SNPs studied showed association with ORR and PFS, with maximum evidence at the marker rs2282055. The ORR was 25%, 15%, and 0% for the G/G, G/T and T/T genotypes of PD-L1 rs2282055, respectively. The G allele of PD-L1 rs2282055 was significantly associated with better clinical response compared with the T allele (P = 0.0339 [Cochran-Armitage trend test]). The median PFS time was 2.6 months (95% confidence interval [CI], 1.8 months to 4.3 months) for the G/G and G/T genotypes and 1.8 months (95% confidence interval [CI], 0.4 months to 2.2 months) for the T/T genotype (P = 0.0163). Moreover, the C/C and C/G genotypes of PD-L1 rs4143815 were significantly associated with better ORR and PFS in NSCLC patients treated with nivolumab. These results suggest that rs2282055 and rs4143815 may be a biomarker for the efficacy of nivolumab.
Light controlled assembly of silver nanoparticles
Authors: Polywka Andreas , Tückmantel Christian , Görrn Patrick
Published: March 2017

Metal nanoparticles show a particularly strong interaction with light, which is the basis for nanoparticle plasmonics. One of the main goals of this emerging research field is the alignment of nanoparticles and their integration into sophisticated nanostructures providing a tailored interaction with light. This assembly of nanoparticles at well-controlled substrate sites often involves expensive technological approaches, such as electron beam lithography in order to fabricate the nanoparticle structures. Furthermore difficult numerical simulations are needed to predict their optical properties. Both requirements, fabrication and prediction, complicate a cost-efficient exploitation of nanoparticle plasmonics in optoelectronic devices. Here we show that silver nanoparticles deposited under exposure to visible light arrange in a way that the resulting structure shows an optimized interaction with that light. This way, the light not only controls the nanoparticle alignment with an estimated accuracy of well below 20 nm during deposition from the liquid phase, but also defines the optical properties of the growing structure, and therefore complicated prediction is not needed.
Xeno-free culture of human pluripotent stem cells on oligopeptide-grafted hydrogels with various molecular designs
Authors: Chen Yen-Ming , Chen Li-Hua , Li Meng-Pei , Li Hsing-Fen , Higuchi Akon , Kumar S. Suresh , Ling Qing-Dong , Alarfaj Abdullah A. , Munusamy Murugan A. , Chang Yung , Benelli Giovanni , Murugan Kadarkarai , Umezawa Akihiro
Published: March 2017

Establishing cultures of human embryonic (ES) and induced pluripotent (iPS) stem cells in xeno-free conditions is essential for producing clinical-grade cells. Development of cell culture biomaterials for human ES and iPS cells is critical for this purpose. We designed several structures of oligopeptide-grafted poly (vinyl alcohol-co-itaconic acid) hydrogels with optimal elasticity, and prepared them in formations of single chain, single chain with joint segment, dual chain with joint segment, and branched-type chain. Oligopeptide sequences were selected from integrin- and glycosaminoglycan-binding domains of the extracellular matrix. The hydrogels grafted with vitronectin-derived oligopeptides having a joint segment or a dual chain, which has a storage modulus of 25 kPa, supported the long-term culture of human ES and iPS cells for over 10 passages. The dual chain and/or joint segment with cell adhesion molecules on the hydrogels facilitated the proliferation and pluripotency of human ES and iPS cells.
Significantly Enhanced Energy Storage Density by Modulating the Aspect Ratio of BaTiO3 Nanofibers
Authors: Zhang Dou , Zhou Xuefan , Roscow James , Zhou Kechao , Wang Lu , Luo Hang , Bowen Chris R.
Published: March 2017

There is a growing need for high energy density capacitors in modern electric power supplies. The creation of nanocomposite systems based on one-dimensional nanofibers has shown great potential in achieving a high energy density since they can optimize the energy density by exploiting both the high permittivity of ceramic fillers and the high breakdown strength of the polymer matrix. In this paper, BaTiO3 nanofibers (NFs) with different aspect ratio were synthesized by a two-step hydrothermal method and the permittivity and energy storage of the P(VDF-HFP) nanocomposites were investigated. It is found that as the BaTiO3 NF aspect ratio and volume fraction increased the permittivity and maximum electric displacement of the nanocomposites increased, while the breakdown strength decreased. The nanocomposites with the highest aspect ratio BaTiO3 NFs exhibited the highest energy storage density at the same electric field. However, the nanocomposites with the lowest aspect ratio BaTiO3 NFs achieved the maximal energy storage density of 15.48 J/cm3 due to its higher breakdown strength. This contribution provides a potential route to prepare and tailor the properties of high energy density capacitor nanocomposites.
Plasmonic metamaterial for electromagnetically induced transparency analogue and ultra-high figure of merit sensor
Authors: Wu Dong , Liu Yumin , Yu Li , Yu Zhongyuan , Chen Lei , Li Ruifang , Ma Rui , Liu Chang , Zhang Jinqiannan , Ye Han
Published: March 2017

In this work, using finite-difference time-domain method, we propose and numerically demonstrate a novel way to achieve electromagnetically induced transparency (EIT) phenomenon in the reflection spectrum by stacking two different types of coupling effect among different elements of the designed metamaterial. Compared with the conventional EIT-like analogues coming from only one type of coupling effect between bright and dark meta-atoms on the same plane, to our knowledge the novel approach is the first to realize the optically active and precise control of the wavelength position of EIT-like phenomenon using optical metamaterials. An on-to-off dynamic control of the EIT-like phenomenon also can be achieved by changing the refractive index of the dielectric substrate via adjusting an optical pump pulse. Furthermore, in near infrared region, the metamaterial structure can be operated as an ultra-high resolution refractive index sensor with an ultra-high figure of merit (FOM) reaching 3200, which remarkably improve the FOM value of plasmonic refractive index sensors. The novel approach realizing EIT-like spectral shape with easy adjustment to the working wavelengths will open up new avenues for future research and practical application of active plasmonic switch, ultra-high resolution sensors and active slow-light devices.
Variation in sensitivity of large benthic Foraminifera to the combined effects of ocean warming and local impacts
Authors: Prazeres Martina , Roberts T. Edward , Pandolfi John M.
Published: March 2017

Large benthic foraminifera (LBF) are crucial marine calcifiers in coral reefs, and sensitive to environmental changes. Yet, many species successfully colonise a wide range of habitats including highly fluctuating environments. We tested the combined effects of ocean warming, local impacts and different light levels on populations of the common LBF Amphistegina lobifera collected along a cross-shelf gradient of temperature and nutrients fluctuations. We analysed survivorship, bleaching frequency, chlorophyll a content and fecundity. Elevated temperature and nitrate significantly reduced survivorship and fecundity of A. lobifera across populations studied. This pattern was exacerbated when combined with below optimum light levels. Inshore populations showed a consistent resistance to increased temperature and nitrate levels, but all populations studied were significantly affected by light reduction. These findings demonstrated the capacity of some populations of LBF to acclimate to local conditions; nonetheless improvements in local water quality can ultimately ameliorate effects of climate change in local LBF populations.
Comparison of Co(ii) adsorption by a crosslinked carboxymethyl chitosan hydrogel and resin: behaviour and mechanism
Authors: Luo Wenqiang , Bai Zhishan , Zhu Yong
Published: March 2017

This article studies the possible chemical and physical adsorption mechanism for Co(ii) onto the crosslinked carboxymethyl chitosan hydrogel and resin.
Sonochemistry – an innovative opportunity towards a one-pot three-component synthesis of novel pyridylpiperazine derivatives catalysed by meglumine in water
Authors: Tabassum S. , Govindaraju S. , Pasha M. A.
Published: March 2017

An unprecedented and expeditious synthetic strategy for rapid access to a diversity-oriented library of novel functionalized pyridyl piperazine derivatives is reported.
Controllable TiO2 heterostructure with carbon hybrid materials for enhanced photoelectrochemical performance
Authors: Ge Yilin , Bai Hongye , Li Chunfa , Guan Peng , Wu Linlan , Xu Dongbo , Hong Yuanzhi , Fan Weiqiang , Shi Weidong
Published: March 2017

A TiO2/RGO/C3N4 heterostructure has been successfully designed and fabricated, and the narrow bandgap and conductivity of RGO and C3N4 could be beneficial for the generation and separation of photocharges.
Enhancement of hydrogen production of a Cu–TiO2nanocomposite photocatalyst combined with broad spectrum absorption sensitizer Erythrosin B
Authors: Zhang Piyong , Song Ting , Wang Tingting , Zeng Heping
Published: March 2017

A broad spectrum absorption photocatalytic system has been expected for a long time, especially for catalysts where the absorption mainly concentrates on the ultraviolet region, like TiO2.
Proton-coupled electron transfer promotes the reduction of ferrylmyoglobin by uric acid under physiological conditions
Authors: Zawadzki Andressa de , Cardoso Daniel R. , Skibsted Leif H.
Published: March 2017

Uric acid prevents the oxidative toxic effects of ferrylmyoglobin during red meat digestion.
Sub-micron silk fibroin film with high humidity sensibility through color changing
Authors: Li Qingsong , Qi Ning , Peng Yu , Zhang Yafeng , Shi Lei , Zhang Xiaohua , Lai Yuekun , Wei Kai , Kim Ick Soo , Zhang Ke-Qin
Published: March 2017

A Sub-micron silk fibroin film with high humidity sensibility through color changing is achieved by spin-coating fibroin aqueous solution, and it can be potentially applied for low-cost and fast humidity detection, as well as anti-counterfeit labels.
Understanding rectifying and nonlinear bipolar resistive switching characteristics in Ni/SiNx/p-Si memory devices
Authors: Kim Sungjun , Chang Yao-Feng , Park Byung-Gook
Published: March 2017

Two resistive memory devices were prepared with different doping concentrations in the silicon bottom electrodes to explore the self-rectifying and nonlinear resistive switching characteristics of Ni/SiNx/p-Si devices.
Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics
Authors: Kadlcik S. , Kamenik Z. , Vasek D. , Nedved M. , Janata J.
Published: March 2017

Combinatorial biosynthesis for more efficient antibiotics: 150 novel lincosamides prepared by combining lincomycin and celesticetin biosynthetic pathways.
Gel-based morphological design of zirconium metal–organic frameworks
Authors: Bueken Bart , Van Velthoven Niels , Willhammar Tom , Stassin Timothée , Stassen Ivo , Keen David A. , Baron Gino V. , Denayer Joeri F. M. , Ameloot Rob , Bals Sara , De Vos Dirk , Bennett Thomas D.
Published: March 2017

The ability of zirconium metal–organic frameworks (MOFs) to gelate under specific synthetic conditions opens up new opportunities in the preparation and shaping of hierarchically porous MOF monoliths, which could be directly implemented for catalytic and adsorptive applications.
A highly stretchable and robust non-fluorinated superhydrophobic surface
Authors: Ju Jie , Yao Xi , Hou Xu , Liu Qihan , Zhang Yu Shrike , Khademhosseini Ali
Published: March 2017

A stretchable, rub-proof superhydrophobic surface was realized by a chemically bonded silicone elastomer network covering the surface of silica microparticles to form enhanced micro-scale surface roughness.
Cross-linked antifouling polysaccharide hydrogel coating as extracellular matrix mimics for wound healing
Authors: Tang Yuqin , Cai Xueqin , Xiang Yingying , Zhao Yu , Zhang Xinge , Wu Zhongming
Published: March 2017

Antifouling hydrogel coating based on natural polysaccharide could effectively promote diabetic wound healing.
Novel method for standard addition signal analysis in voltammetry
Authors: Ciepiela Filip , Węgiel Krystian
Published: March 2017

A new procedure for standard addition analysis in voltammetry based on the slope of the peak at the inflection point (SSAA) is proposed.
In situ quantification and evaluation of ClO−/H2S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H+-activated mechanism
Authors: Fu Qiang , Chen Guang , Liu Yuxia , Cao Ziping , Zhao Xianen , Li Guoliang , Yu Fabiao , Chen Lingxin , Wang Hua , You Jinmao
Published: March 2017

A new dual-response probe for in situ quantification of ClO−/H2S homeostasis in inflammatory gastric tissue.
Determination of fragrance ingredients in fish by ultrasound-assisted extraction followed by purge & trap
Authors: Chen Changer Long , Löfstrand Karin , Adolfsson-Erici Margaretha , MacLeod Matthew
Published: March 2017

Acid-sensitive organic chemicals representative of fragrance materials can be isolated from fish tissue by extraction into a mild solvent followed by capture from the gas phase.
Spontaneous phase transition of hexagonal wurtzite CoO: application to electrochemical and photoelectrochemical water splitting
Authors: Jang Kyu Yeon , Park Gisang , Oh Kyung Hee , Seo Jong Hyeok , Nam Ki Min
Published: March 2017

Spontaneous phase transition of h-CoO to β-Co(OH)2 is widely applicable for electrochemical and photoelectrochemical water oxidation reactions.
Distinct activation of Cu-MOR for direct oxidation of methane to methanol
Authors: Kim Younhwa , Kim Tae Yong , Lee Hyunjoo , Yi Jongheop
Published: March 2017

Enhancement of methanol production was achieved by N2O activation in virtue of the facile formation of active sites at elevated temperatures.
Rational design of a luminescent nanoprobe for hypoxia imaging in vivo via ratiometric and photoluminescence lifetime imaging microscopy
Authors: Yu Qi , Huang Tianci , Li Yipeng , Wei Huanjie , Liu Shujuan , Huang Wei , Du Jing , Zhao Qiang
Published: March 2017

A nanoprobe has been employed for hypoxia imagingin vitroandin vivo viaratiometric and, photoluminescence lifetime imaging techniques.
A highly stable sodium solid-state electrolyte based on a dodeca/deca-borate equimolar mixture
Authors: Duchêne L. , Kühnel R.-S. , Rentsch D. , Remhof A. , Hagemann H. , Battaglia C.
Published: March 2017

Na2(B12H12)0.5(B10H10)0.5, a new solid-state sodium electrolyte is shown to offer high Na+ conductivity of 0.9 mS cm−1 at 20 °C.
Synthesis of highly efficient azure-to-blue-emitting Zn–Cu–Ga–S quantum dots
Authors: Kim Bu-Yong , Kim Jong-Hoon , Lee Ki-Heon , Jang Eun-Pyo , Han Chang-Yeol , Jo Jung-Ho , Jang Ho Seong , Yang Heesun
Published: March 2017

Non-Cd, azure-to-blue-emitting Zn–Cu–Ga–S/ZnS quantum dots with exceptional quantum yields of 78–83% are synthesized.
Entropy-driven homochiral self-sorting of a dynamic library
Authors: Atcher Joan , Bujons Jordi , Alfonso Ignacio
Published: March 2017

The efficient homochiral self-sorting of pseudopeptidic macrocycles, observed from a simple dynamic library, is driven by entropy.
Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex
Authors: Liu Suyan , Zheng Wei , Wu Kui , Lin Yu , Jia Feifei , Zhang Yang , Wang Zhaoying , Luo Qun , Zhao Yao , Wang Fuyi
Published: March 2017

A correlated ToF-SIMS and CLSM imaging strategy was developed to visualize the subcellular distribution of an organoruthenium anticancer complex, showing its accumulation in both cell membrane and nuclei and verifying its dual-targeting feature.
Thermal spin-crossover with a large hysteresis spanning room temperature in a mononuclear complex
Authors: Tailleur E. , Marchivie M. , Daro N. , Chastanet G. , Guionneau P.
Published: March 2017

The substitution of sulphur by selenium leads to spin-crossover single-crystals exhibiting a large hysteresis centred at room temperature.
Perspectives on metal–organic frameworks with intrinsic electrocatalytic activity
Authors: Solomon Marcello B. , Church Tamara L. , D'Alessandro Deanna M.
Published: March 2017

This highlight article focuses on the rapidly emerging area of electrocatalytic metal–organic frameworks (MOFs) with a particular emphasis on those systems displaying intrinsic activity.
Understanding how cAMP-dependent protein kinase can catalyze phosphoryl transfer in the presence of Ca2+and Sr2+: a QM/MM study
Authors: Pérez-Gallegos Ayax , Garcia-Viloca Mireia , González-Lafont Àngels , Lluch José M.
Published: March 2017

Theoretical results demonstrate for the first time at the molecular level that the overall PKAc-catalyzed phosphoryl-transfer reaction is plausible with Ca2+and Sr2+, alkaline earth metal ions other than Mg2+, which is in good agreement with experiments.
Thermal conductivity of glassy GeTe4by first-principles molecular dynamics
Authors: Bouzid Assil , Zaoui Hayat , Luca Palla Pier , Ori Guido , Boero Mauro , Massobrio Carlo , Cleri Fabrizio , Lampin Evelyne
Published: March 2017

A transient thermal regime is achieved in glassy GeTe4by first-principles molecular dynamics following the recently proposed “approach-to-equilibrium” methodology.
Methylene-bridged, intramolecular donor–acceptor systems based on rare-earth metals and phosphinomethanides
Authors: Pieper Martin , Lamm Jan-Hendrik , Neumann Beate , Stammler Hans-Georg , Mitzel Norbert W.
Published: March 2017

Geminally bonded intramolecular Lewis-pairs based on rare-earth metal phosphinomethanides were prepared, characterized and tested for their reactivity towards H2, CO2and alkynes.
Schiff base thorium(iv) and uranium(iv) chloro complexes: synthesis, substitution and oxidation chemistry
Authors: Stobbe Brian C. , Powell Douglas R. , Thomson Robert K.
Published: March 2017

Schiff base chloro complexes of U(iv) and Th(iv) are prepared and provide access to rare pseudo trans diazide species, and a facile pathway to uranyl complexes through oxidation with NaNO2.
The impact of silicon solar cell architecture and cell interconnection on energy yield in hot & sunny climates
Authors: Haschke Jan , Seif Johannes P. , Riesen Yannick , Tomasi Andrea , Cattin Jean , Tous Loïc , Choulat Patrick , Aleman Monica , Cornagliotti Emanuele , Uruena Angel , Russell Richard , Duerinckx Filip , Champliaud Jonathan , Levrat Jacques , Abdallah Amir A. , Aïssa Brahim , Tabet Nouar , Wyrsch Nicolas , Despeisse Matthieu , Szlufcik Jozef , De Wolf Stefaan , Ballif Christophe
Published: March 2017

A series resistance induced by cell interconnections will lead to a worse TCPMPP of solar modules compared with cells.
Surface induced crystallization of polymeric nano-particles: effect of surface roughness
Authors: Jabbarzadeh Ahmad , Chen Xin
Published: March 2017

Molecular dynamics simulations are conducted to study the crystallization of a polymeric system as a drop in an isolated state and on a surface. It is shown that crystallization kinetics for the polymeric system as a particle on a smooth surface is much faster than in the isolated form. We show however that as the surface becomes rough the crystallization rate of the polymeric particle decreases. The effect of roughness was compared for two cases of a polymer drop, partially (Wenzel state) and fully (fully confined) wetting the cavities on a rough surface. In both cases it was observed that crystallization was slower than that on a smooth surface, and crystal growth rate was decreased by increasing the characteristic roughness ratio. The crystallization on rough surfaces was still faster than that of the isolated polymer drop.
Observational constraints on particle acidity using measurements and modelling of particles and gases
Authors: Murphy J. G. , Gregoire P. K. , Tevlin A. G. , Wentworth G. R. , Ellis R. A. , Markovic M. Z. , VandenBoer T. C.
Published: March 2017

In many parts of the world, the implementation of air quality regulations has led to significant decreases in SO2 emissions with minimal impact on NH3 emissions. In Canada and the United States, the molar ratio of NH3 : SO2 emissions has increased dramatically between 1990 and 2014. In many regions of North America, this will lead the molar ratio of NHx : SO4, where NHx is the sum of particle phase NH4+ and gas phase NH3, and SO4 is the sum of particle phase HSO4− and SO42−, to exceed 2. A thermodynamic model (E-AIM model II) is used to investigate the sensitivity of particle pH, and the gas-particle partitioning of NHx and inorganic nitrate, to the atmospheric NHx : SO4 ratio. Steep increases in pH and the gas fraction of NHx are found as NHx : SO4 varies from below 1 to above 2. The sensitivity of the gas fraction of nitrate also depends strongly on temperature. The results show that if NHx : SO4 exceeds 2, and the gas and particle phase NHx are in equilibrium, the particle pH will be above 2. Observations of the composition of particulate matter and gas phase NH3 from two field campaigns in southern Canada in 2007 and 2012 have median NHx : SO4 ratios of 3.8 and 25, respectively. These campaigns exhibited similar amounts of NH3, but very different particle phase loadings. Under these conditions, the pH values calculated using the observations as input to the E-AIM model were in the range of 1–4. The pH values were typically higher at night because the higher relative humidity increased the particle water content, diluting the acidity. The assumption of equilibration between the gas and particle phase NHx was evaluated by comparing the observed and modelled gas fraction of NHx. In general, E-AIM was able to reproduce the partitioning well, suggesting that the dominant constituents contributing to particle acidity were measured, and that the estimated pH values were realistic. These results suggest that regions of the world where the ratio of NH3 : SO2 emissions is beginning to exceed 2 on a molar basis may be experiencing rapid increases in aerosol pH of 1–3 pH units. This could have important consequences for the rates of condensed phase reactions that are acid-catalyzed.
Are lutein, lycopene, and β-carotene lost through the digestive process?
Authors: Kopec Rachel E. , Gleize Béatrice , Borel Patrick , Desmarchelier Charles , Caris-Veyrat Catherine
Published: March 2017

The bioavailability of many carotenoids has been assessed, but little attention has been given to the metabolism of these antioxidant compounds during digestion.
Informing rational design of graphene oxide through surface chemistry manipulations: properties governing electrochemical and biological activities
Authors: Wang Yan , Gilbertson Leanne M.
Published: March 2017

The electrochemical and biological activities are synergistically driven by the physicochemical properties of graphene oxide and reduced graphene oxide.
Intensification studies of heterogeneous catalysts: probing and overcoming catalyst deactivation during liquid phase operation
Authors: Hammond Ceri
Published: March 2017

In addition to high levels of activity and selectivity, promising heterogeneous catalysts must also possess sufficient levels of stability. This tutorial review covers the topic of heterogeneous catalyst deactivation during liquid phase operation.
Organocatalytic valorisation of glycerol via a dual NHC-catalysed telescoped reaction
Authors: Axelsson A. , Antoine-Michard A. , Sundén H.
Published: March 2017

NHC-catalysis enables the successful functionalisation of glycerol through a telescoped reaction strategy involving carbonation and the subsequent oxidative esterification.
Determination of the platinum concentration of a Pt/silica nanocomposite decorated with ultra small Pt nanoparticles using single particle inductively coupled plasma mass spectrometry
Authors: Sápi András , Kéri Albert , Kálomista Ildikó , Dobó Dorina G. , Ákos Szamosvölgyi Ákos Szamosvölgyi , Juhász Koppány L. , Ákos Kukovecz Ákos Kukovecz , Kónya Zoltán , Galbács Gábor
Published: March 2017

The accurate load concentration of ultra small nanoparticles in a Pt/SiO2 nanocomposite is determined by the novel spICP-MS analytical method.
Selective synthesis of mono- and bis-butenolide α-aminomethyl adducts
Authors: Talbi Arbia , Arfaoui Aïcha , Bsaibess Talia , Lotfi Efrit Mohamed , Gaucher Anne , Prim Damien , M′Rabet Hédi
Published: March 2017

The preparation of mono- and bis-butenolide α-adducts is described using α-bromomethylene-γ-butenolide and primary as well as secondary amines.
Bis(2-oxo-7-azaindolin-3-ylidene)benzodifuran-dione-based donor–acceptor polymers for high-performance n-type field-effect transistors
Authors: Zhang Guobing , Dai Yanrong , Song Kuychan , Lee Hansol , Ge Feng , Qiu Longzhen , Cho Kilwon
Published: March 2017

Two donor–acceptor (D–A) conjugated polymers were synthesized using a strongly electron-deficient unit as the acceptor, and dithiophene and (E)-2-(2-(thiophen-2-yl)vinyl)thiophene as the donor units.
Photosensitive polydimethylsiloxane networks for adjustable-patterned films
Authors: Jellali Rachid , Alexandre Michaël , Jérôme Christine
Published: March 2017

Mixtures of polydimethylsiloxanes bearing coumarin moieties provide films with photo-adjustable topography.
Enantioselective synthesis of a cyclobutane analogue of Milnacipran
Authors: Nguyen Dinh-Vu , Gravel Edmond , Buisson David-Alexandre , Nicolas Marc , Doris Eric
Published: March 2017

An optically active cyclobutane analogue of Milnacipran was synthesized from phenylacetonitrile, and its cis-stereochemistry was controlled by an epimerization step.
Poly(l-lysine) modified zein nanofibrous membranes as efficient scaffold for adhesion, proliferation, and differentiation of neural stem cells
Authors: Miao Yingling , Yang Ruirui , Deng David Y. B. , Zhang Li-Ming
Published: March 2017

Cell viability, adhesion, proliferation, and differentiation of neural stem cells (NSCs) on zein nanofibrous membranes could be improved by poly(l-lysine) modification.
CdTe/CdS quantum dot-labeled fluorescent immunochromatography test strips for rapid detection of Escherichia coli O157:H7
Authors: Yu Jinlu , Su Jing , Zhang Jing , Wei Xuetuan , Guo Ailing
Published: March 2017

Immunochromatography test strips have been widely used to detect foodborne pathogens due to their high sensitivity, stability and specificity, and the selection of the label is an important factor.
Assembly of carbon nanotubes into microparticles with tunable morphologies using droplets in a non-equilibrium state
Authors: Tomii Sakurako , Yamada Masumi , Mizuno Masahiro , Yamada Yasuhiro , Kojima Takashi , Kushida Masahito , Seki Minoru
Published: March 2017

A microfluidic process to assemble carbon nanotubes (CNTs) into micrometer-sized particles is presented, using aqueous droplets in a non-equilibrium state.
Total synthesis of aristolactam alkaloids via synergistic C–H bond activation and dehydro-Diels–Alder reactions
Authors: Reddy Mallu Chenna , Jeganmohan Masilamani
Published: March 2017

A concise total synthesis of aristolactam alkaloids by a synergistic combination of C–H bond activation and dehydro-Diels–Alder reactions is described.
A DFT calculation-inspired Rh(i)-catalyzed reaction via suppression of α-H shift in α-alkyldiazoacetates
Authors: Liu Shunying , Jiang Jun , Chen Jianghui , Wei Qinghua , Yao Wenfeng , Xia Fei , Hu Wenhao
Published: March 2017

An α-alkyldiazoacetate-involved three-component reaction has been developed via the suppression of intramolecular α-H shift and 1,2-proton transfer by Rh(i) complexes.
A critical review on tin halide perovskite solar cells
Authors: Konstantakou Maria , Stergiopoulos Thomas
Published: March 2017

In this work, we reviewed the evolution of the performance of photovoltaic devices (single junction and tandems) using Sn-containing perovskites.
Dual-functional CoAl layered double hydroxide decorated α-Fe2O3 as an efficient and stable photoanode for photoelectrochemical water oxidation in neutral electrolyte
Authors: Chong Ruifeng , Wang Baoyun , Su Caihong , Li Deliang , Mao Liqun , Chang Zhixian , Zhang Ling
Published: March 2017

An α-Fe2O3 photoanode was decorated with a dual-functional CoAl layered double hydroxide for photoelectrochemical water oxidation. The composite photoanode exhibits high efficiency and excellent stability in neutral electrolyte.
Mediating physicochemical properties and paclitaxel release of pH-responsive H-type multiblock copolymer self-assembly nanomicelles through epoxidation
Authors: Luo Yan-Ling , Zhang Xue-Yin , Wang Yuan , Han Fang-Jie , Xu Feng , Chen Ya-Shao
Published: March 2017

We focused on modulation of the physicochemical and biomedical properties of copolymer nanomicellesviaepoxidation, which provided significant improvements.
Rapid laser-induced photochemical conversion of sol–gel precursors to In2O3 layers and their application in thin-film transistors
Authors: Dellis Spilios , Isakov Ivan , Kalfagiannis Nikolaos , Tetzner Kornelius , Anthopoulos Thomas D. , Koutsogeorgis Demosthenes C.
Published: March 2017

We report the development of indium oxide (In2O3) transistors via a single step laser-induced photochemical conversion process of a sol–gel metal oxide precursor.
Red green blue emissive lead sulfide quantum dots: heterogeneous synthesis and applications
Authors: Hou Bo , Cho Yuljae , Kim Byung-Sung , Ahn Docheon , Lee Sanghyo , Park Jong Bae , Lee Young-Woo , Hong John , Im Hyunsik , Morris Stephen M. , Sohn Jung Inn , Cha SeungNam , Kim Jong Min
Published: March 2017

RGB emissive PbS QDs with high quantum yield and remarkable photovoltaic open-circuit voltages are achieved through heterogeneous synthesis methodologies.
New WOLEDs based on π-extended azatrioxa[8]circulenes
Authors: Ivaniuk K. B. , Baryshnikov G. V. , Stakhira P. Y. , Pedersen S. K. , Pittelkow M. , Lazauskas A. , Volyniuk D. , Grazulevicius J. V. , Minaev B. F. , Ågren H.
Published: March 2017

New stable WOLEDs based on π-extended azatrioxa[8]circulenes have been fabricated.
Luminescence spectroscopy of lead-halide perovskites: materials properties and application as photovoltaic devices
Authors: Kanemitsu Yoshihiko
Published: March 2017

This review summarizes the optical properties of lead-halide-perovskite thin films, single crystals, and solar-cell devices.
Combining the converse humidity/resistance response behaviors of rGO films for flexible logic devices
Authors: Tai Yanlong , Bera Tushar Kanti , Lubineau Gilles , Yang Zhenguo
Published: March 2017

We report the fabrication of a series of flexible logical devices based on the converse humidity/resistance response of rGO films.
Aligned carbon and graphite fibers prepared from poly(3,4-ethylenedioxythiophene) single crystals synthesized by solid-state polymerization and their supercapacitor performance
Authors: Yan Bairu , Matsushita Satoshi , Akagi Kazuo
Published: March 2017

Aligned carbon and graphite fibers with high crystallinity are prepared from doped and dedoped poly(3,4-ethylenedioxythiophene) fibers synthesized through solid-state polymerization.
Beyond binary: optical data storage with 0, 1, 2, and 3 in polymer films
Authors: Wei Peiran , Li Bowen , de Leon Al , Pentzer Emily
Published: March 2017

The evergrowing amount of data created and collected is met with the increased need to store this data. By using a quaternary instead of binary code, data storage capabilities are vastly improved.
Fine‐grained azimuthal direction of arrival estimation using received signal strengths
Authors: Maddio S. , Cidronali A. , Passafiume M. , Collodi G. , Maurri S.
Published: March 2017

We propose a direction of arrival (DoA) estimation technique, which is enabled by a single printed patch antenna capable of four reconfigurable beams at the operative frequency of 2.45 GHz. The direction of the messages sent by a nomadic wireless node is estimated and stored without the need of lengthy offline measurements, by correlating the real‐time received signal strength actual data and the expected antenna beams. The comparison is implemented with a least square technique with an extremely reduced computational cost. Experimental validations demonstrate the DoA estimation capability, with a mean error <2.3° with a variance of 1.9° within a domain of 90°.
Improved free matrix‐based integral inequality for stability of systems with time‐varying delay
Authors: Zhi Ya‐Li , He Yong , Wu Min
Published: March 2017

The stability problem for systems with time‐varying delay is investigated. Firstly, an augmented Lyapunov–Krasovskii functional is constructed by introducing a double integral of the second‐order derivative. To estimate its derivative, an improved free matrix‐based integral inequality is presented, which is more powerful than the improved Jensen inequality and Wirtinger inequality. As a result, some less conservative stability criteria in terms of linear matrix inequalities are obtained. Finally, two numerical examples are provided to demonstrate the validity and superiority of the proposed methods.
Carrier signal injection‐based sensorless control for permanent magnet synchronous machine drives with tolerance of signal processing delays
Authors: Xu Peilin , Zhu Ziqiang
Published: March 2017

In the case of high precision A/D converters, carrier signal injection based position estimation methods can adopt a relatively higher injection frequency (>1/10 pulse width modulation (PWM) switching frequency), which can lead to enhanced system bandwidths. However, simultaneously, signal processing delay effects (e.g., PWM duty ratio updating delay, etc.) become prominent, resulting in large phase shifts of carrier currents. On the other hand, the high frequency (HF) resistance effects may also be enlarged. Consequently, large oscillating position estimation errors will arise for the pulsating injection method due to carrier signal distortions induced by the delay and HF resistance effects. In order to suppress the undesirable position errors, based on the theoretical analyses, a new compensation strategy of maximizing the useful inductive saliency part and minimising the resistive saliency components using a PI regulator is proposed. The proposed position error suppression method is very easy and simple to implement, and moreover can significantly improve the sensorless control performance. Furthermore, the similar compensation strategy can also be applied for the position error compensation for rotating injection method as will also be discussed in this paper. Finally, the theoretical analyses and compensation effectiveness are validated by experiments on a laboratory interior permanent magnet machine.
Phased antenna arrays based on non‐volatile resistive switches
Authors: Dragoman Mircea , Aldrigo Martino , Adam Gina
Published: March 2017

The authors propose a phased patch‐antenna array working in the X‐band (i.e. 8–12 GHz), in which the beam‐steering is obtained by means of two‐terminal non‐volatile resistive switches (or memristors). These novel components have a simple design and a tunable resistance (suitable for electromagnetic matching), and could replace other volatile switching‐type devices (such as PIN diodes, MEMS, etc.), providing good radiofrequency (RF) performance and low‐power consumption. They also offer the advantage of non‐volatility state, i.e. the controlling signals do not need to be applied continuously, which entails a decrease of the power consumption and a reduction of antenna's sensitivity to power outages. The paper models a simple non‐volatile resistive switch working in the microwave and millimetre frequency bands, then simulates, based on these switches, a frequency‐tunable dipole antenna and a double patch‐antenna array with beam steering capabilities. The authors obtained a multi‐resonant array, which exhibits a maximum steering angle of ±28°. They also report the fabrication and characterisation of a resistive switch, based on TiO2−x that shows promising performance for high endurance and retention, with low insertion loss and high isolation. The results of this study represent the starting point for a new family of microwave tunable devices.
Integrated data‐driven model‐based approach to condition monitoring of the wind turbine gearbox
Authors: Qian Peng , Ma Xiandong , Cross Philip
Published: March 2017

Condition monitoring (CM) is considered an effective method to improve the reliability of wind turbines (WTs) and implement cost‐effective maintenance. This study presents a single hidden‐layer feedforward neural network (SLFN), trained using an extreme learning machine (ELM) algorithm, for CM of WTs. Gradient‐based algorithms are commonly used to train SLFNs; however, these algorithms are slow and may become trapped in local optima. The use of an ELM algorithm can dramatically reduce learning time and overcome issues associated with local optima. In this study, the ELM model is optimised using a genetic algorithm. The residual signal obtained by comparing the model and actual output is analysed using the Mahalanobis distance (MD) measure due to its ability to capture correlations among multiple variables. An accumulated MD value, obtained from a range of components, is used to evaluate the health of a gearbox, one of the critical subsystems of a WT. Models have been identified from supervisory control and data acquisition (SCADA) data obtained from a working wind farm. The results show that the proposed training method is considerably faster than traditional techniques, and the proposed method can efficiently identify faults and the health condition of the gearbox in WTs.