bluuebunny/crossref_metadata_2025 huggingface dataset:
Diretrizes para Autores
Authors: Executiva Editoria
Published: May 2022

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Analysis of inland waterway vessel propulsion by criterion efficiency, ecology and safety
Authors: Łosiewicz Zbigniew , Mironiuk Waldemar , Kaup Magdalena , Łozowicka Dorota , Ślączka Wojciech
Published: May 2022

The paper analyses the propulsion systems of inland waterway vessels according to the criteria of economic efficiency, ecology and safety. The professional experience of the authors and their expert knowledge indicate that always the increase of safety level as well as ecological solutions are realized at the expense of economic efficiency. Therefore, arguing for the result of such analysis, the features of water bodies, port infrastructure and elements which should influence the selection of propulsion systems, features of various types of power and fuels with their energy value guaranteeing the swimming range were described. Types of propulsion systems were characterized and a model of selection of propulsion system to the type of sailing was presented. The analysis presented in the article is necessary for a reliable assessment of the accuracy of the selection of the propulsion system for the actual conditions of operation of sea and inland waterway vessels, i.e. for the type of the vessel and its suitability to perform operational tasks on specific waterways.
El derecho a una salud intercultural
Authors: Rodríguez Cintia Daniela
Published: May 2022

Este artículo abordará el derecho a la salud intercultural, a partir de conceptualizar el acceso a la salud y la interacción respetuosa entre varias culturas en los distintos ámbitos (político, social, cultural, lingüístico, etario, género) que constituyen una sociedad compleja. El objetivo se centra en delimitar el concepto de interculturalidad y de diálogo intercultural desde un enfoque de justicia epistémica. Se espera que el análisis situado de la atención sanitaria intercultural promueva políticas públicas, destinadas a construir una mirada intercultural, que propicie un diálogo horizontal y una interacción respetada en todos los ámbitos de la sociedad.
Migraciones y (Des) usos del sistema de salud. Narrativas sobre dificultades de acceso y estrategias de atención/autoatención en un barrio periurbano de La Matanza
Authors: Abal Yamila Soledad
Published: May 2022

En el marco del PICT 3166/2015 “Migraciones, interculturalidad y territorio: Cartografías multiescalares de la inclusión social”, se desarrolla una línea de investigación que busca analizar las especificidades que presentan los procesos de salud-enfermedad-atención (PSEA) en barrios periurbanos de González Catán, habitados por conjuntos sociales empobrecidos y caracterizados por tener trayectorias biográficas marcadas por diversas experiencias de movilidad. A partir de un enfoque cualitativo, se analizan las narrativas de quienes habitan estos barrios, reconociendo los modos en los que diversas desigualdades se yuxtaponen y se expresan en dificultades de acceso a la atención y en el desarrollo de una pluralidad de estrategias que procuran sortear aquellas dificultades. Como resultado, se evidencia una multiplicidad de actores y de modelos concernientes a la salud y a su cuidado y a la existencia de conciencias alternativas frente a los diferentes problemas. A su vez, las dificultades de acceso y las percepciones sobre el funcionamiento de los servicios del sistema público de salud, ayudan a avanzar en la comprensión de determinados “caminos terapeúticos” y poner en tensión algunos de los estereotipos vinculados a la salud migrante que se encuentran arraigados en la opinión pública y en los medios de comunicación.
nascimento no cárcere
Authors: Peters Evandro , Ningeliski Adriane de Oliveira
Published: May 2022

A Constituição Federal em seu artigo 5º, inciso L prevê que às presidiárias serão asseguradas condições para que possam permanecer com seus filhos no período de amamentação. O presente estudo versa sobre as consequências do nascimento dessas crianças dentro de presídios à luz do princípio do melhor interesse previsto na lei 8069/90, verificando-se se o tratamento dado pelo Estado à criança nascida no cárcere está em consonância com tal princípio. A metodologia adotada para o presente trabalho é qualitativa e o método de abordagem é dedutivo, partindo-se da premissa que o sistema prisional hoje é considerado um espaço onde direitos fundamentais como o da dignidade da pessoa humana não são respeitados, situação contrária daquilo que preserva o princípio do melhor interesse da criança. Através dos estudos realizados, conclui-se que a permanência da criança com a mãe é um direito Constitucional, o qual deve ser preservado; no entanto, o tratamento do Estado para com as mães e os nascidos no cárcere é totalmente omisso, não atende suas necessidades essenciais de saúde e bem-estar e não se encontra em consonância com o princípio do melhor interesse da criança.
Prestação dos serviços públicos à luz da Lei Geral de Proteção de Dados (LGPD)
Authors: Rodrigues Alison Cleiton , Paula Alan Pinheiro de
Published: May 2022

A Lei Geral de Proteção de Dados Pessoais (LGPD) foi estabelecida para promover a regulação do tratamento dos dados pessoais do indivíduo, seguindo princípios, deveres e direitos tanto do seu titular, quanto do usuário desses dados – pessoas físicas e jurídicas, além do poder público. O objetivo deste artigo é mostrar os conceitos, a aplicação e a abrangência dessa Lei, indicando os desafios para que possa ser aprimorada. Para explicar o alcance da LGPD é apresentado seu relacionamento com o serviço de administração pública. Em complemento, são comentados os aspectos do acesso aos dados pessoais e ambientes sensíveis no serviço público, com a utilização de referências de diversos autores para referir o modo de resposta do serviço público na solicitação de acesso de terceiros. A metodologia empregada neste trabalho é qualitativa, com base técnica na legislação em vigor, em publicações específicas sobre o tema.
Hostage to history – questioning the duration of systemic antimicrobial therapy for the treatment of canine superficial bacterial folliculitis
Authors: Sousa Candace A. , Chatfield Jenifer , File Thomas M. , Koch Sandra N. , Leu Daryl B. , Loeffler Anette , Loft Klaus Earl , Souza Clarissa , Weese J. Scott
Published: May 2022

Current guidelines for the use of systemic antimicrobials for the treatment of superficial bacterial folliculitis in dogs include the recommendation that the disease be treated for a minimum of 3 weeks and for at least 1 week beyond clinical resolution. With increasing antimicrobial resistance being noted for bacteria involved in this condition, as well as the increased use of evidence-based medicine, this dogma needs to be reevaluated.
Mipymes sonorenses ante el COVID-19. Una aproximación al impacto económico por género
Authors: Robles-Robles María del Rosario Fátima , Hurtado-Bringas Beatriz Alejandra
Published: May 2022

El impacto en la actividad económica por el confinamiento y cierre temporal decretado a empresas no esenciales por el COVID-19, ocasionó un impacto diferenciado por género en las Mipymes sonorenses. Objetivo: describir el impacto económico de la contingencia por COVID-19 en Mipymes sonorenses identificando diferencias por género. Metodología: estudio exploratorio, comparativo, de corte transversal utilizando técnicas de encuesta, método de muestreo aleatorio simple, tamaño de muestra 107 de empresarios y empresarias del sector formal en Sonora. Para el procesamiento de datos se utilizó el Programa SPSS versión 25. Limitaciones: debido a que la encuesta se aplicó durante el confinamiento por COVID-19, se pidió a las cámaras empresariales el apoyo para responderla, registrándose una menor participación por parte de los municipios. Resultados: se encontraron más correlaciones significativas para las mujeres empresarias que para los hombres en: empleos generados, nivel de ingresos, despido de trabajadores y actividad esencial, así como los problemas producto del COVID-19. Conclusión: se encontró evidencia que para las mujeres empresarias Mipymes de Sonora, el efecto de la pandemia es mayor que para los hombres de este tipo de empresas.
Estrategia socioeconómica para el desarrollo forestal sustentable del ejido Tetahuichi, Guachochi, Chihuahua
Authors: Salazar-Chávez Karen Alexandra , Luján-Álvarez Concepción , Olivas-García Jesús Miguel , Grijalva-Martínez Iván , Baray-Guerrero María del Rosario
Published: May 2022

Objetivo: el objetivo fue establecer estrategias socioeconómicas para impulsar el desarrollo forestal sustentable del ejido Tetahuichi, Guachochi, Chihuahua, México. Metodología: se estudiaron variables. La entrevista fue la técnica para la toma de información y como instrumento el cuestionario. El muestreo fue aleatorio simple tomando en cuenta a los ejidatarios como unidad de muestreo. Se realizó un diagnóstico socioeconómico para conocer la problemática existente y potencialidades del ejido, a la vez se identificaron áreas de oportunidad para promover el desarrollo socioeconómico del ejido. Resultado: se establecieron estrategias socioeconómicas para fortalecer el desarrollo forestal sustentable del ejido en las diferentes áreas de oportunidad identificadas, tomando en cuenta la participación de sus habitantes, aspectos económicos y sociales, las necesidades e intereses de los involucrados en el desarrollo forestal comunitario del ejido, así como aspectos político-institucionales y legales relacionados con el medio ambiente y el desarrollo sustentable. Limitaciones: la investigación no incluyó la dimensión ambiental, además, se identificó escaso conocimiento organizacional y administrativo de los ejidatarios. Conclusiones: que el ejido tiene recursos suficientes tanto naturales y forestales, así como de personal para ser competitivos y que se genere un bienestar para la población y conservación del ecosistema forestal.
Modification of the DBSCAN algorithm for big data clustering
Authors:   Institute of Information Technology, Azerbaijan National Academy of Sciences, Fakhraddingizi Aygul
Published: May 2022

The development of Information and Communication Technologies (ICT) has led to the rapid growth of digital information and the consequent emergence of the concept of large-scale data. Therefore, there is a need to delve into large-scale data and its essence, the possibilities and problems of analytical technologies. Clustering is one of the main methods of analyzing big data. The main purpose of clustering is to separate data into clusters according to certain characteristics. When clusters come in different sizes, densities, and shapes, the problem of detection arises. The article explores the density-based DBSCAN clustering algorithm for working with big data. One of the main features of this algorithm is to create an effective cluster by detecting the noise points in big data. During the implementation of the algorithm, real databases containing noise points were used. Metrics such as adjusted rand index, homogeneity, Davis-Boldin index were used to evaluate the results of the experiment. The proposed method was more effective than the traditional DBSCAN algorithm in detecting noise points.
The diagnosis of rheumatic fever by the clinical presentation of Sydenham chorea: case report
Authors: Curi Mariana , Castanheira Juliana , Maldi Isabela Gomes , Mendonça Marcella , Cardoso Josephine , Barsam Fabiana , Lima Jussara
Published: May 2022

Sydenhams chorea is characterized by involuntary movements of the distal limbs and face region and mainly affects females during their childhood. It occurs by complication of pharyngotonsillitis caused by beta hemolytic streptococcus of the A group. This case report aims to describe a case of rheumatic fever diagnosed from a clinical picture of Sydenhams chorea. A descriptive case study of a female child was carried out, she was twelve years old, she sought the emergency care unit with involuntary movements in lower and upper rights limbs and face for five days, she had a previous history of infection an upper respiratory infection with self-limited evolution. The physical examination found, was in good general condition, with extension and flexion limbs movements, opening and closing hands movements, finger and face movements, complementary exams, they did not demonstrate any alterations, except ASLO of 217IU/ml. It was started a treatment with haloperidol, benzathine penicillin and and school progress evolved asymptomatic with improved choreatotic movements. This report demonstrates the relation between Sydenhams chorea and the late diagnosis of rheumatic fever, in addition to explaining the good prognosis from adequate and early therapeutic management.
Caracterización sociopolítica de las fronteras en Colombia y América Latina
Authors: Rey Pinto Eva María
Published: May 2022

Los espacios fronterizos son zonas donde convergen múltiples dinámicas sociales, políticas y económicas. Esto implica que dichas líneas divisorias invisibles sean de interés geopolítico para los Estados, ya que a través de estas no solo se demarcan los territorios, sino también se crean situaciones comunes, como flujos migratorios, actividades económicas legales e ilegales y relaciones sociales, que requieren especial atención, principalmente cuando las fronteras son amplias y porosas, como es el caso de América Latina. El presente capítulo busca presentar una caracterización sociopolítica de las fronteras en la región latinoamericana, con el fin de identificar los principales retos y oportunidades que enfrentan los Estados. Esto, a través de: 1) una conceptualización de los espacios fronterizos, por medio de la geopolítica crítica y las fronteras marítimas virtuales; 2) la exploración de las fronteras en América Latina y Colombia; 3) una revisión de los principales fenómenos sociales y retos de las áreas fronterizas de la región; y 4) conclusiones.
Economías ilícitas en las fronteras de Colombia
Authors: López Pulgarín Nicolás Antonio
Published: May 2022

Este capítulo tiene el objetivo de analizar la coyuntura que se ha desarrollado a lo largo de las zonas fronterizas de Colombia, debido al establecimiento de economías ilícitas a manos de actores criminales que, en consecuencia, generan inseguridad y violencia en las poblaciones que habitan allí. En primer lugar, se hará una aproximación conceptual hacia las nociones de economía ilícita y seguridad en el país. En segundo lugar, se identificarán los factores determinantes de la instalación de actores criminales en ciertas zonas fronterizas, y se hará un análisis metodológico de su operatividad, para, así, establecer su impacto económico y socioambiental en el país. Y en tercer lugar, se examinarán las medidas que el Estado colombiano ha tomado ante este panorama.
Historia de la policía en Colombia: balance y sugerencias de investigación
Authors: Mera Hansel , Sánchez-Salcedo José Fernando
Published: May 2022

El objetivo de este artículo es proponer un balance de los estudios historiográficos sobre la policía en Colombia. Su desarrollo metodológico implica una revisión bibliográfica analítica que contextualiza algunos referentes de orden global y latinoamericano cuyos resultados se expresan en la primera y segunda parte, mientras que en su tercera y cuarta parte propone un balance del caso colombiano. Se concluye que se trata de un campo de estudios en emergencia y consolidación para el caso nacional con rutas de exploración pendientes, y se proponen algunas rutas de investigación para venideros abordajes centrados en el caso colombiano.
A new monotypic genus of the subfamily Tetrastichinae (Hymenoptera: Chalcidoidea: Eulophidae) from China
Authors:   School of Life Sciences, East China Normal University, Shanghai 200241, China, Xu J.-Y. , Liu Y.-J. ,   School of Life Sciences, East China Normal University, Shanghai 200241, China, He Z.-Q. ,   Museum of Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China
Published: May 2022

New genus Zhijilingia Xu, Liu et He, gen. n. (type species: Zhijilingia tettigonia Xu, Liu et He, sp. n.) is described from Sichuan, South China. This new genus can be distinguished from other genera of Tetrastichinae by following characters: antenna with 3 anelli and 4 funicular segments, only one clava segment, all funicular segments slender and longer than broad, funicular segments almost same in length, mesoscutum without a median line, propodeum with a distinct median carina, the whole rim of propodeal spiracle exposed, postmarginal vein absent. The new species probably parasitize eggs of the katydids Prohimerta dispar (Bey-Bienko, 1951) (Orthoptera: Tettigoniidae).
Sepse neonatal: as principais linhas de tratamento com antimicrobianos
Authors: Nery Clemilson Bruno da Silva , Costa Daniele Lima da , Freitas Francisco Miguel da Silva , Silva Iara de Brito , Junior Ruy Sergio Gomes Santos Muge , Guimarães Márcia Cristina Monteiro , Monteiro Maria Gabriela Perdigão Barros , Ledo Paulo José Carneiro , Silva Marivaldo de Moraes e , Júnior Rodrigo Antônio Prazeres da Silva
Published: May 2022

Objetivo: Descrever por meio de estudos científicos as principais linhas de tratamento com antimicrobianos da sepse precoce e tardia no recém-nascido. Métodos: O estudo caracterizou-se como revisão integrativa da literatura com abordagem qualitativa descritiva. Foram selecionados 11 artigos relacionados ao tema sepse neonatal e antibioticoterapia, publicados entre 2015 a 2020 na Biblioteca Virtual de Saúde (BVS) e no Scientific Electronic Library Online (SCIELO). Resultados: A sepse neonatal é classificada como precoce e tardia. A primeira relaciona-se ao período pré-natal e seus riscos de contaminação. A segunda a fatores assistenciais em unidades hospitalares que levam à infecção. A ampicilina e gentamicina são eficazes no tratamento empírico da sepse neonatal precoce, embora outros estudos em instituições hospitalares tenham apontado para utilização de outros medicamentos como primeira escolha. Na sepse neonatal tardia o tratamento deu-se com oxacilina, amicacina, vancomicina, meropenem, cefepima e outros remédios eficazes diante do resultado da hemocultura relacionada ao microrganismo e à sensibilidade dos medicamentos. Considerações finais: A sepse neonatal é um problema mundial relacionado ao período gestacional ou à assistência hospitalar. Muitas vezes pode ser evitada e tratada sem deixar sequelas no indivíduo. Contudo, é necessário conhecimento médico diante às principais medicações e formas corretas de uso em recém-nascidos.
PDL with Negation of Atomic Programs
Authors:   Institute for Theoretical Computer Science, TU Dresden, Lutz Carsten , Walther Dirk ,   Institute for Theoretical Computer Science, TU Dresden
Published: May 2022

Propositional dynamic logic (PDL) is one of the most succesful variants of modal logic. To make it even more useful for applications, many extensions of PDL have been considered in the literature. A very natural and useful such extension is with negation of programs. Unfortunately, it is long-known that reasoning with the resulting logic is undecidable. In this paper, we consider the extension of PDL with negation of atomic programs, only. We argue that this logic is still useful, e.g. in the context of description logics, and prove that satisfiability is decidable and EXPTIME-complete using an approach based on Büchi tree automata.
Female and Male auto- and heterostereotypes of Russian and Belarusian youth
Authors: Karnialovich M. M. , Kazarenkov V. I.
Published: May 2022

The article is devoted to the actual problem of the social cognition psychology: stereotyping as a mechanism of interpersonal perception and self-perception in the context of the biological sex of the subject and the object of social perception. The results of an empirical study of male and female auto- and heterostereotypes of young women and young men, performed on a combined (Russian-Belarusian) sample, are presented. Content features and modality (emotional coloring) of male and female auto- and heterostereotypes were revealed using a free associative experiment. The content and structure of male and female auto- and heterostereotypes that exist in the ordinary consciousness of modern youth have been determined and analysed. Based on the results of the correlation analysis, the strength, direction and meaningful characteristics of the relationship between auto- and heterostereotypes in the male and female samples have been revealed. The results of the study are of interest to specialists in the field of psychology of social cognition, differential psychology, social psychology of personality, psychology of heterosexual relationships.
Characterising cheerfulness as a value for young people
Authors: Lesin A. M.
Published: May 2022

This article is presented the study’s results of the place of the cheerfulness value in the young people’s value-based world view. This value relates with the severity of value career orientations, significance of other instrumental, terminal ones, as well as with the significance, implementation and conflict between the significance and implementation of internal and external values. The value under study is to a greater extent associated with the personal sphere of young people, is not associated with the manifestation of their initiative and is negatively associated with some career orientations. The cheerfulness is an important, but rather a potential value, which does not have much motivational potential. The article suggests a hypothesis, that the image of a reliable person is negatively associated with emotionality and a positive attitude to life, and positively – with the manifestation of seriousness and will. It is concluded that this value is an internal value that is not associated with demonstrating their success to other people and social status, but is an indicator and consequence of their personal internal development and is more connected with warm friendly relationships and emotional richness of life.
Non-fungible token: a promising digital tool for business
Authors: Kashevarova N. A. , Starikova I. S.
Published: May 2022

This paper presents a review of the current status and development trends of the non-fungible tokens’ technology (NFT), which are digital rights to unique objects recorded in the blockchain. The object of the study is the non-interchangeable token technology. The subject of the study is the fields of practical application of NFT. The method is an analytical review of scientific publications. The current state and socio-cultural sources of the NFT market related to works of art and media objects are analysed. The technological and legal problems preventing the wide spread of NFT in the business environment are identified. The prospects for the use of non-fungible tokens in the field of protection and commercialization of patent law objects are considered.
Regulating the international activities of Russian higher education institutions
Authors: Bondarenko V. V. , Nazarova N. A. , Taisheva K. S. , Penzina D. P.
Published: May 2022

One of the key conditions for increasing of Russian education competitiveness in the international market is the active involvement of universities in various international cooperation forms. For this purpose, an analysis of international, federal, local normative legal acts regulating the international activities of Russian higher education institutions was carried out. The international aspect was considered using a comparative legal analysis of agreements between Russia and other countries. The article presents the results of the analysis of the principles of international agreements regulating the educational process in Russian universities. According to the research, a model, regulating the international activities of Russia’s universities, was analysed. The study of regulatory legal acts in Russia’s higher education led to the conclusion about the legislation elaboration level, to outline the prospects for development and the possibility of expanding the domestic universities international activities.
Application of experience economy tools in the hotel industry
Authors: Pshenichnykh J. A. , Adamyuk A. P.
Published: May 2022

Modern trends in the tourism and hospitality industry, influenced by the pandemic and increasing competition, are actualizing the need to find new innovative approaches to managing the development of hotel enterprises to increase the social and emotional value of hotel services for consumers. The ability of the hospitality business to make the desired impression on the consumer will determine its competitive position and success in the market. Insufficient coverage of fundamentally important issues related to the study of the essence of the concept of impression economics, insufficient theoretical consideration of the theoretical and methodological aspects of the concept of impression economics in the management of the development of hospitality enterprises confirm the relevance and purpose of this study. The work examined the essence of the concept, the main ideas, and trends of recent years in the field of the formation of the impression economy; an attempt was made to use the terminology and tools of the impression economy in relation to the hotel product.
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1
Authors: Poehner Ina , Quotadamo Antonio , Panecka-Hofman Joanna , Luciani Rosaria , Santucci Matteo , Linciano Pasquale , Landi Giacomo , Pisa Flavio Di , Iacono Lucia Dello , Pozzi Cecilia , Mangani Stefano , Gul Sheraz , Witt Gesa , Ellinger Bernhard , Kuzikov Maria , Santarem Nuno , Cordeiro-da-Silva Anabela , Costi Maria Paola , Venturelli Alberto , Wade Rebecca
Published: May 2022

The optimization of compounds with multiple targets is a difficult multidimensional problem in the drug discovery cycle. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Computational fragment-based design of novel pteridine derivatives along with iterations of crystallographic structure determination allowed for the derivation of a structure-activity relationship for multitarget inhibition. The approach yielded compounds showing apparent picomolar inhibition of T. brucei pteridine reductase 1 (PTR1), nanomolar inhibition of L. major PTR1, and selective submicromolar inhibition of parasite dihydrofolate reductase (DHFR) versus human DHFR. Moreover, by combining design for polypharmacology with a property-based on-parasite optimization, we found three compounds that exhibited micromolar EC50 values against T. brucei brucei, whilst retaining their target inhibition. Our results provide a basis for the further development of pteridine-based compounds, and we expect our multitarget approach to be generally applicable to the design and optimization of anti-infective agents.
Activation of Alkyl Chlorides Enabled by Zirconocene and Photoredox Catalysis
Authors: Okita Toshimasa , Aida Kazuhiro , Tanaka Keisuke , Ota Eisuke , Yamaguchi Junichiro
Published: May 2022

C–Cl bond cleavage of unactivated alkyl chlorides with zirconocene and photoredox catalysis has been achieved. The present protocol exhibited a broader scope of alkyl chlorides compared to the preceding methods with titanocene. This scope expansion could be attribut-ed to the zirconium metal center rendering the C–Cl bond cleavage more endergonic and lowering the transition states.
Remote C(sp3)—H insertion into non-activated bonds: rapid construction of an added-value molecular diverse library
Authors: Miguélez Rubén , Rodríguez-Arias Carlos , Mykhailiuk Pavel , González José M. , Barrio Pablo
Published: May 2022

The synthesis of added-value compounds from raw feedstock materials represents one of the major challenges in synthetic organic chemistry. By using a well-defined intramolecular C—H insertion reaction, it is possible to transform a number of raw feedstock compounds into a library of molecularly complex and diverse compounds. In addition, these compounds display a C—Br bond amenable for further functionalization. A preliminary mechanistic study supports the participation of an elusive gold (I) vinylidene complex as key intermediate of the reaction. The most salient feature of this methodology is the ability to functionalize in a predictable way non-activated C—H bonds without any sort of electronic, geometric or conformational bias.
Sequence Specific Phosphopeptide Enrichment of ZAP-70 regulatory motifs using epitope-imprinted polymer complements
Authors: Incel Anil , Shinde Sudhirkumar , Diez Ignacio A. , Stollenwerk Maria M. , Jensen Ole N. , Sellergren Börje
Published: May 2022

Immunoaffinity enrichment based on antipeptide antibodies coupled to mass spectrometry-based identification and quantification (immuno-MS) is a promising approach to translate proteomics to clinical assays with diagnostic value. This is linked to precision cancer medicine, where immuno-MS based studies of protein phosphorylation dependent-signalling states of cells enable pathway targeted therapies and response monitoring to be developed. Clinically robust methods depend on the availability of high quality phosphopeptide antibodies but these rarely meet the stringent demands on reproducibility, robustness, availability and peptide specificity. We here show that polymer-based “plastic antibodies” prepared by molecular imprinting could play this role. Focusing on the Tyr-492 and Tyr-493 kinase regulatory motif of the SH2 domain in ZAP-70, a critical mediator in T-cell receptor signalling, we show that MIPs can be easily generated to recognize corresponding mono- or di- phosphorylated tryptic peptides in a highly specific manner. The polymers bound their complementary phosphorylated decapeptides with Kd:s in the low µM range in both low aqueous proteomics media and aqueous buffers. Moreover, only minor cross-reactivity was observed for phosphopeptide variants with identical amino acid sequence. Proving their practical value, we demonstrate their use for sequence specific phosphopeptide enrichment from extracts of Jurkat T-cells stimulated to induce protein phosphorylation at either of the two regulatory sites of ZAP-70. We expect the approach to be broadly applicable paving the way for robust, low-cost multiplex phosphopeptide assays.
Plasmonic Photocatalysis in Aqueous Solution: Assessing the Contribution of Thermal Effects and Evaluating the Role of Photogenerated ROS
Authors: Negrín-Montecelo Yoel , Brissaud Charlène , Piquemal Jean-Yves , Govorov Alexander O. , Correa-Duarte Miguel A. , Besteiro Lucas V. , Comesana-Hermo Miguel
Published: May 2022

Plasmon-induced photocatalysis can drive photochemical processes with an unprecedented control of reactivity, using light as sole energy source. Nevertheless, disentangling the relative importance of thermal and non-thermal features upon plasmonic excitation remains a difficult task. In this work we intend to separate the role played by the photogenerated charge carriers from thermal mechanisms in the plasmonic photo-oxidation of a model organic substrate in aqueous solution and using a metal-semiconductor hybrid as model photocatalyst. Accordingly, we present a simple set of experimental procedures and simulations that allow us to discard the thermal dissipation upon plasmonic excitation as the main driving force behind these chemical reactions. Moreover, we also study the photogeneration of reactive oxygen species (ROS), discussing their fundamental role in photo-oxidation reactions and the information they provide regarding the reactivity of the photogenerated electrons and holes.
Enhancing the Performance of Layered Metal-Organic Framework Supercapacitors by Coordination Modulation
Authors: Gittins Jamie W. , Balhatchet Chloe J. , Fairclough Simon M. , Forse Alexander C.
Published: May 2022

Metal-organic frameworks (MOFs) are among the most promising materials for next-generation energy storage systems, including supercapacitors. Few studies, however, have examined the impact of particle morphology and degree of agglomeration on the energy storage performances of these materials. To address this, here we use coordination modulation to synthesise three samples of the conductive MOF Cu3(HHTP)2 (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) with distinct microstructures. Evaluation of the performances of these samples in symmetric supercapacitors with organic and ionic liquid electrolytes demonstrated that samples with weakly agglomerated ‘flake-like’ particles, with short pores and many pore openings, display superior capacitive performances than samples with either weakly agglomerated ‘rod-like’ particle morphologies or strongly agglomerated ‘flake-like’ particles. The results of this study provide a target microstructure for conductive MOFs for energy storage applications.
Solvent Dependence on Cooperative Vibrational Strong Coupling and Cavity Catalysis
Authors: Singh Jaibir , Lather Jyoti , GEORGE Jino
Published: May 2022

Strong light-matter coupling offers a unique way to control chemical reactions at the molecular level. Here, we try to compare the solvent effect on a solvolysis process under cooperative vibrational strong coupling (VSC). Two solvents, ethyl acetate and cyclopentanone are chosen to study cavity catalysis by coupling the C=O stretching band of the reactant and the solvent molecules to a Fabry-Perot cavity mode. Interestingly, both the solvent system catalyze the chemical reaction under cooperative VSC conditions. However, the resonance effect on catalysis is observed at different temperatures for the two solvent systems, which is further confirmed by thermodynamic studies. Cavity detuning and other control experiments suggest that cooperative VSC of the solvent plays a crucial role in modifying the transition state energy of the reaction. These findings, along with other observations, cement the concept of polaritonic chemistry.
Structure and Dynamics of Adsorbed Dopamine on Solvated Carbon Nanotubes and in a CNT Groove
Authors: Jia Qizhang , Venton B. Jill , DuBay Kateri H.
Published: May 2022

Advanced carbon microelectrodes are being developed for the in vivo detection of neurotransmitters, such as dopamine (DA), including many carbon nanotube (CNT) based electrodes. Our prior simulations of DA and dopamine-o-quinone (DOQ) on pristine, flat graphene showed rapid surface diffusion for all adsorbed species, but it is not known how CNT surfaces affect dopamine adsorption and surface diffusivity. In this work, we use molecular dynamics simulations to investigate the adsorbed structures and surface diffusion dynamics of DA and DOQ on CNTs of varying curvature and helicity. In addition, we study DA dynamics in a groove between two aligned CNTs to model the spatial constraints at the junctions within CNT assemblies. We find that the adsorbate diffusion on a solvated CNT surface depends upon curvature. However, this effect cannot be attributed to changes in the surface energy roughness because the lateral distributions of the molecular adsorbates are similar across curvatures, diffusivities on zigzag and armchair CNTs are indistinguishable, and the curvature dependence disappears in the absence of solvent. Instead, adsorbate diffusivities correlate with the vertical placement of the adsorbate's moieties, its tilt angle, its orientation along the CNT axis, and the number of waters in its first hydration shell -- all of which will influence its effective hydrodynamic radius. Finally, DA diffuses into and remains in the groove between a pair of aligned and solvated CNTs, enhancing diffusivity along the CNT axis. These first studies of surface diffusion on a CNT electrode surface are important for understanding the changes in diffusion dynamics of dopamine on nanostructured carbon electrode surfaces.
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis
Authors: Adachi Jun , Kakudo Akemi , Takada Yoko , Isoyama Junko , Ikemoto Narumi , Abe Yuichi , Narumi Ryohei , Muraoka Satoshi , Gunji Daigo , Hara Yasuhiro , Katayama Ryohei , Tomonaga Takeshi
Published: May 2022

The sensitivity of phosphorylation site identification by mass spectrometry has improved markedly. However, the lack of kinase–substrate relationship (KSR) data hinders the improvement of the range and accuracy of kinase activity prediction. In this study, we aimed to develop a method for acquiring systematic KSR data on anaplastic lymphoma kinase (ALK) using mass spectrometry and to apply this method to the prediction of kinase activity. Thirty-seven ALK substrate candidates, including 34 phosphorylation sites not annotated in the PhosphoSitePlus database, were identified by integrated analysis of the phosphoproteome and crosslinking interactome of HEK 293 cells with doxycycline-induced ALK overexpression. Furthermore, KSRs of ALK were validated by an in vitro kinase assay. Finally, using phosphoproteomic data from ALK mutant cell lines and patient-derived cells treated with ALK inhibitors, we found that the prediction of ALK activity was improved when the KSRs identified in this study were used instead of the public KSR dataset. Our approach is applicable to other kinases, and future identification of KSRs will facilitate more accurate estimations of kinase activity and elucidation of phosphorylation signals.
Campo académico de la Pedagogía/Educación Social en Argentina. Trazos de una experiencia en proceso
Authors: Baraldo Natalia
Published: May 2022

Tanto en Europa como en algunos países de América Latina, la Pedagogía/Educación Social viene afianzándose como campo académico y profesional. Este artículo busca aproximarse al surgimiento del campo académico de la Pedagogía Social en Argentina. La metodología utilizada fue el análisis bibliográfico y documental. Como respuesta a la crisis del neoliberalismo, los gobiernos progresistas del período 2003-2015 pretendieron refundar el Estado y con ello imprimieron un nuevo dinamismo a las políticas públicas, entre ellas las socioeducativas. La Pedagogía/Educación Social fue pensada en el marco de una estrategia estatal para la inclusión social y escolar que, no obstante, es tensionada por tradiciones pedagógicas preexistentes. Mientras que desde 2001 se multiplicaban diversas prácticas de educación popular en organizaciones y movimientos sociales populares, la constitución del campo académico de la Pedagogía Social se sitúa a partir de 2007, con la creación de carreras de formación de nivel técnico superior en distintas provincias.
ESTIMATE OF DISK NOT CONTAINING ROOTS OF POLYNOMIAL FUNCTIONS
Authors: Lal Roshan
Published: May 2022

Let is a polynomial of degree. Also let coefficients of polynomial follow a certain pattern of decreasing or increasing in magnitude. Then we have many results for providing the regions containing all the roots of polynomial functions. Here, in this paper we prove a result that gives a disk or circular region containing no roots of function, Thereby our result finally gives annular region containing all roots of polynomial function and hence thereby improves the earlier proved .results.
THE EFFECT OF INFORMATION TECHNOLOGY CAPABILITY, AND STRATEGIC PLANNING ON KNOWLEDGE MANAGEMENT MEDITED ORGANIZATIONAL PERFORMANCE IN THE ARMY CENTRAL IMPLEMENTING AGENCY
Authors: Daryanto Eko , Jasfar Farida , Kusnadi
Published: May 2022

The purpose of this study is to provide input to the leadership of the Indonesian Army National Armed Forces Headquarters regarding the importance of knowledge management on technological developments because this knowledge is one way to create and improve work professionalism in the military, especially the Indonesian Armed Forces.The research design and method used in this research is hypothesis testing. This research is a quantitative non-experimental, using a questionnaire given to 93 respondents. This research was conducted at the Central Implementing Agency for the Indonesian National Armed Forces.The results of this study indicate that: The effect of Information Technology Capability, Strategic Planning on Organizational Performance is positive and significant. The influence of Knowledge Management on Organizational Performance is positive and significant. The influence of Knowledge Management mediating Information Technology Capability, Strategic Planning on Organizational Performance is positive and significant. It means that the higher/positive mediation of Knowledge Management on Information Technology Capability, Strategic Planning, the higher/positive Organizational Performance.Theoretical implications: Knowledge Management as a mediating of Information Technology Capability, Strategic Planning is able to improve Organizational Performance, by increasing Knowledge Management through increasing its dimensions it will be able to improve the Organizational Performance of the Central Implementing Body of the Indonesian Armed Forces.
Pathological Q Wave in Electrocardiographic Examinations of Patients with Schizophrenia
Authors: Kanat Selçuk , Demirci Hakan , Aydin Ufuk , Taymur Ibrahim , Ciftci Fatih , Yalçintaş Emre , Ocakoglu Gokhan , Tenekecioglu Erhan
Published: May 2022

Aim: The aim of our study was to investigate the frequency of the ischemic and proarrhythmic electrocardiographic (ECG) changes in schizophrenia patients compared to normal healthy population. Methods: This study was planned retrospectively.
ECG documents were obtained from the first day of admission to patients' psychiatric clinic. The study involved 190 hospitalized schizophrenia patients and 134 healthy controls. The rhythm of the patient, presence of channelopathy,
hypertrophy findings of cardiac cavities, conduction defects, ischemic changes, p-wave length, p-wave dispersion (PWD), the presence of fragmented QRS (fQRS), QT dispersion were considered in the ECG records. Results: The mean
systolic and diastolic blood pressure were higher in the control group (p<0.001). Smoking was more prevalent among patients with schizophrenia. The heart rate was higher in the schizophrenia group than control group (85.5 vs
70.5 beats/min;p<0.001). QT-dispersion time was also higher in the schizophrenia group (35 milliseconds versus 55 milliseconds; p<0.001). P-wave dispersion time was found higher in schizophrenia group (30 to 47.50 milliseconds,
p<0.001). The incidence of fragmented QRS (fQRS) was 36.30% (n: 69) in the schizophrenic group and 7.5% (n:10) in the healthy control group (p=0.001). Pathological Q-wave frequency was about 10 times higher in patients with
schizophrenia (p<0,001). Conclusions: The proarrhythmic and ischemic electrocardiographic changes may explain the high frequency of premature deaths seen in patients with schizophrenia. When psychiatrists evaluate schizophrenia
patients, they should be aware of these cardiac findings and should be in close contact with cardiologists as necessary.
Evaluation of Nutritional Status and Pressure Sores of Elderly Patıents Admitted to Home Health Care Services
Authors: Hıdır Bekar Asım , Tuncer Özge
Published: May 2022

Aim: The aim of this study was to evaluate the nutritional status and decubitus status of elderly patients who applied to the Home Health Care Service at a training and research hospital and to determine the relationship between them.
Methods: The study was a descriptive and cross-sectional study that was conducted face-to-face with 364 elderly patients who matched the inclusion criteria. The Malnutrition Universal Screening Tool (MUST) screening test was used
to measure the presence of malnutrition and was classified in three categories as low, medium and high risk. Physical examination was performed to detect the presence of pressure sores. Results: Among the participants 30 patients
(8.24%) had pressure sores and 113 of them (31.04%) had malnutrition. A positive relationship was found between nutritional deficiency and pressure sores. Malnutrition risk was determined using the MUST and 69.00% of the patients
carried low risk, 25.80% carried medium risk and 5.20% carried high risk. There was a statistically significant difference between the number of people living with the patient at home, the duration of home health care and the duration
of pressure sores (p <0.05). While there was no relationship between malnutrition and gender, income and educational status, a significant difference for age, marital status, caregiver presence, chronic disease and pressure
sores was observed. Conclusions: Pressure sores and malnutrition are not rare among the elderly patients admitted to Home Health Care Services and they are interrelated. Effective policies need to be established, implemented and
monitored to prevent malnutrition and pressure sores. Home care providers and family doctors should take these situations into account when visiting patients at home.
Metachronous Lung Cancer in the Opposite Lung in a Patient with Long-survival Small Cell Lung Carcinoma
Authors: Öztürk Gül Ayşen
Published: May 2022

Small Cell Lung Cancer (SCLC) is an aggressive disease that accounts for 14% of all lung cancers. It is known that the risk of developing a second primary tumor is high in cured SCLC. Here, we aimed to present metachronous cancer that
developed in the contralateral lung at the 11th year in our case of small cell lung cancer, which was fully cured. A 52-year-old female patient at the time of diagnosis received chemoradiotherapy with a diagnosis of limited-stage
small cell lung cancer in the left lung 14 years ago. At the 11th year of follow-up, segmentectomy was performed because of the detection of Stage1 lung adenocarcinoma in the contralateral lung. She is in the 3rd year postoperatively
without any problems. Patients with long survival should be carefully evaluated for metachronous lung cancer in their controls. It should not be forgotten that curative treatment of second primary tumors that can be detected in
the early period will positively affect the survival of patients.
Evaluation of Physicians’ Knowledge and Attitudes about Neural Therapy
Authors: Demir İlknur , Öztürk Güzin Zeren , Önlen İrem
Published: May 2022

Aim: In this study, we aimed to evaluate the knowledge and attitudes of physicians about Neural Therapy (NT). Methods: This single-center, descriptive study included 265 physicians. A questionnaire consisting of questions on the knowledge
and attitudes of physicians about NT as well as demographic data was applied face-to-face. SPSS 15.0 program was used. Values with p<0.05 were considered statistically significant. Results: From the results of the study, 196
physicians (74.00%) knew about NT. The mean age of doctors who knew about NT was 36.07±10.72 (minimum: 24, maximum: 62). When asked about the clinical conditions for which they think NT application is effective, they gave the answers:
low back pain, neck-shoulder pain, fibromyalgia and headache. Conclusions: Three-quarters of the physicians stated that they knew about NT. The fact that the majority of those who didn’t know about NT wanted to receive education
on NT shows that physicians are open to learning about this subject.