bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures S1-S10 from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Authors: Oser Matthew G. , Fonseca Raquel , Chakraborty Abhishek A. , Brough Rachel , Spektor Alexander , Jennings Rebecca B. , Flaifel Abdallah , Novak Jesse S. , Gulati Aditi , Buss Elizabeth , Younger Scott T. , McBrayer Samuel K. , Cowley Glenn S. , Bonal Dennis M. , Nguyen Quang-De , Brulle-Soumare Laura , Taylor Paula , Cairo Stefano , Ryan Colm J. , Pease Elizabeth J. , Maratea Kim , Travers Jon , Root David E. , Signoretti Sabina , Pellman David , Ashton Susan , Lord Christopher J. , Barry Simon T. , Kaelin William G.
Published: April 2023

Supplementary Figure S1 shows RB1 is synthetic lethal with multiple genes that regulate chromosomal segregation. Supplementary Figure S2 shows genetic inactivation of AURKB is synthetic lethal with RB1 loss in NCI-H82 cells. Supplementary Figure S3 shows pharmacological inhibition of Aurora B kinase is synthetic lethal with RB1 loss in NCI-H82 cells. Supplementary Figure S4 shows RB1 is synthetic lethal with AURKB in other SCLC and NSCLC cell lines. Supplementary Figure S5 shows RB1-/-, MYC unamplified cancer cell lines are sensitive to AZD2811. Supplementary Figure S6 shows RB1 is synthetic lethal with AURKB in breast cancer cell lines. Supplementary Figure S7 shows pRB loss exacerbates mitotic abnormalities caused by Aurora B kinase inhibition. Supplementary Figure S8 shows AZD2811 is well tolerated in mice at concentrations used in our efficacy studies. Supplementary Figure S9 shows AZD2811 inhibits Aurora B Kinase in vivo, induces polyploidy, apoptosis, and its anti-tumor effects are on-target. Supplementary Figure S10 shows MYC, MYCN, MYCL1 copy number variation, mRNA expression, and immunohistochemistry in SCLC PDX models.
Supplementary Tables 1-5 from Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
Authors: Sukumaran Sujita , Watanabe Norihiro , Bajgain Pradip , Raja Kanchana , Mohammed Somala , Fisher William E. , Brenner Malcolm K. , Leen Ann M. , Vera Juan F.
Published: April 2023

Consolidated supplementary tables for nanostring data
Supplementary Fig. S2 from Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
Authors: Sukumaran Sujita , Watanabe Norihiro , Bajgain Pradip , Raja Kanchana , Mohammed Somala , Fisher William E. , Brenner Malcolm K. , Leen Ann M. , Vera Juan F.
Published: April 2023

Differential gene expression profile of SmarT-cells vs CAR T cells
Supplementary Fig. S1 from Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
Authors: Sukumaran Sujita , Watanabe Norihiro , Bajgain Pradip , Raja Kanchana , Mohammed Somala , Fisher William E. , Brenner Malcolm K. , Leen Ann M. , Vera Juan F.
Published: April 2023

PSCA, TGFβ and IL4 overexpression at the pancreatic tumor site
Table S5 from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

DMC identity and annotation for mouse Idh2, Dnmt3a, and Idh2/Dnmt3a cohorts.
Table S3 (part 3) from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

DMC identity and annotation for all clusters. This is part 3/3 (file split by columns due to upload limitations)
Table S3 (part 2) from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

DMC identity and annotation for all clusters. This is part 2/3 (file split by columns due to upload limitations)
Table S2 from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

Extended high throughput mutation profiling.
Figures S1-S18 from Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer
Authors: Annala Matti , Vandekerkhove Gillian , Khalaf Daniel , Taavitsainen Sinja , Beja Kevin , Warner Evan W. , Sunderland Katherine , Kollmannsberger Christian , Eigl Bernhard J. , Finch Daygen , Oja Conrad D. , Vergidis Joanna , Zulfiqar Muhammad , Azad Arun A. , Nykter Matti , Gleave Martin E. , Wyatt Alexander W. , Chi Kim N.
Published: April 2023

Supplementary Figures S1 - S18
Table S1 from The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2
Authors: Tutuncuoglu Beril , Cakir Merve , Batra Jyoti , Bouhaddou Mehdi , Eckhardt Manon , Gordon David E. , Krogan Nevan J.
Published: April 2023

Cancer drugs targeting the identified virus-host protein-protein interactions of SARS-CoV-2
Figure S4 from MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Sodir Nicole M. , Kortlever Roderik M. , Barthet Valentin J.A. , Campos Tania , Pellegrinet Luca , Kupczak Steven , Anastasiou Panayiotis , Swigart Lamorna Brown , Soucek Laura , Arends Mark J. , Littlewood Trevor D. , Evan Gerard I.
Published: April 2023

Myc instructs immediate onset of transition to pancreatic adenocarcinoma in KMpdx1 mice
Figure S8 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

MTHFR suppression attenuates the anti-leukemic effect of JQ1 in an Cbfb-MYH11-driven AML mouse model.
Figure S5 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Methotrexate and OTX015 are antagonistic in various AML cell lines.
Supplementary Data from Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade
Authors: Torrejon Davis Y. , Abril-Rodriguez Gabriel , Champhekar Ameya S. , Tsoi Jennifer , Campbell Katie M. , Kalbasi Anusha , Parisi Giulia , Zaretsky Jesse M. , Garcia-Diaz Angel , Puig-Saus Cristina , Cheung-Lau Gardenia , Wohlwender Thomas , Krystofinski Paige , Vega-Crespo Agustin , Lee Christopher M. , Mascaro Pau , Grasso Catherine S. , Berent-Maoz Beata , Comin-Anduix Begoña , Hu-Lieskovan Siwen , Ribas Antoni
Published: April 2023

Supplementary Tables
Figure S5 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

Persistent antigen exposure results in high inhibitory receptor and Tbet expression.
Supplementary Figures S1-S5 from Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia
Authors: Pei Shanshan , Pollyea Daniel A. , Gustafson Annika , Stevens Brett M. , Minhajuddin Mohammad , Fu Rui , Riemondy Kent A. , Gillen Austin E. , Sheridan Ryan M. , Kim Jihye , Costello James C. , Amaya Maria L. , Inguva Anagha , Winters Amanda , Ye Haobin , Krug Anna , Jones Courtney L. , Adane Biniam , Khan Nabilah , Ponder Jessica , Schowinsky Jeffrey , Abbott Diana , Hammes Andrew , Myers Jason R. , Ashton John M. , Nemkov Travis , D'Alessandro Angelo , Gutman Jonathan A. , Ramsey Haley E. , Savona Michael R. , Smith Clayton A. , Jordan Craig T.
Published: April 2023

Supplementary Figures S1-S5 supporting Main Figures 1-5.
Supplementary Data from The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
Authors: Hallin Jill , Engstrom Lars D. , Hargis Lauren , Calinisan Andrew , Aranda Ruth , Briere David M. , Sudhakar Niranjan , Bowcut Vickie , Baer Brian R. , Ballard Joshua A. , Burkard Michael R. , Fell Jay B. , Fischer John P. , Vigers Guy P. , Xue Yaohua , Gatto Sole , Fernandez-Banet Julio , Pavlicek Adam , Velastagui Karen , Chao Richard C. , Barton Jeremy , Pierobon Mariaelena , Baldelli Elisa , Patricoin Emanuel F. , Cassidy Douglas P. , Marx Matthew A. , Rybkin Igor I. , Johnson Melissa L. , Ou Sai-Hong Ignatius , Lito Piro , Papadopoulos Kyriakos P. , Jänne Pasi A. , Olson Peter , Christensen James G.
Published: April 2023

Supplementary Composite Figure File
Supplementary Table S6 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Authors: Clarke Matthew , Mackay Alan , Ismer Britta , Pickles Jessica C. , Tatevossian Ruth G. , Newman Scott , Bale Tejus A. , Stoler Iris , Izquierdo Elisa , Temelso Sara , Carvalho Diana M. , Molinari Valeria , Burford Anna , Howell Louise , Virasami Alex , Fairchild Amy R. , Avery Aimee , Chalker Jane , Kristiansen Mark , Haupfear Kelly , Dalton James D. , Orisme Wilda , Wen Ji , Hubank Michael , Kurian Kathreena M. , Rowe Catherine , Maybury Mellissa , Crosier Stephen , Knipstein Jeffrey , Schüller Ulrich , Kordes Uwe , Kram David E. , Snuderl Matija , Bridges Leslie , Martin Andrew J. , Doey Lawrence J. , Al-Sarraj Safa , Chandler Christopher , Zebian Bassel , Cairns Claire , Natrajan Rachael , Boult Jessica K.R. , Robinson Simon P. , Sill Martin , Dunkel Ira J. , Gilheeney Stephen W. , Rosenblum Marc K. , Hughes Debbie , Proszek Paula Z. , Macdonald Tobey J. , Preusser Matthias , Haberler Christine , Slavc Irene , Packer Roger , Ng Ho-Keung , Caspi Shani , Popović Mara , Faganel Kotnik Barbara , Wood Matthew D. , Baird Lissa , Davare Monika Ashok , Solomon David A. , Olsen Thale Kristin , Brandal Petter , Farrell Michael , Cryan Jane B. , Capra Michael , Karremann Michael , Schittenhelm Jens , Schuhmann Martin U. , Ebinger Martin , Dinjens Winand N.M. , Kerl Kornelius , Hettmer Simone , Pietsch Torsten , Andreiuolo Felipe , Driever Pablo Hernáiz , Korshunov Andrey , Hiddingh Lotte , Worst Barbara C. , Sturm Dominik , Zuckermann Marc , Witt Olaf , Bloom Tabitha , Mitchell Clare , Miele Evelina , Colafati Giovanna Stefania , Diomedi-Camassei Francesca , Bailey Simon , Moore Andrew S. , Hassall Timothy E.G. , Lowis Stephen P. , Tsoli Maria , Cowley Mark J. , Ziegler David S. , Karajannis Matthias A. , Aquilina Kristian , Hargrave Darren R. , Carceller Fernando , Marshall Lynley V. , von Deimling Andreas , Kramm Christof M. , Pfister Stefan M. , Sahm Felix , Baker Suzanne J. , Mastronuzzi Angela , Carai Andrea , Vinci Maria , Capper David , Popov Sergey , Ellison David W. , Jacques Thomas S. , Jones David T.W. , Jones Chris
Published: April 2023

Supplementary Table S6
Supplementary Table S5 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Authors: Clarke Matthew , Mackay Alan , Ismer Britta , Pickles Jessica C. , Tatevossian Ruth G. , Newman Scott , Bale Tejus A. , Stoler Iris , Izquierdo Elisa , Temelso Sara , Carvalho Diana M. , Molinari Valeria , Burford Anna , Howell Louise , Virasami Alex , Fairchild Amy R. , Avery Aimee , Chalker Jane , Kristiansen Mark , Haupfear Kelly , Dalton James D. , Orisme Wilda , Wen Ji , Hubank Michael , Kurian Kathreena M. , Rowe Catherine , Maybury Mellissa , Crosier Stephen , Knipstein Jeffrey , Schüller Ulrich , Kordes Uwe , Kram David E. , Snuderl Matija , Bridges Leslie , Martin Andrew J. , Doey Lawrence J. , Al-Sarraj Safa , Chandler Christopher , Zebian Bassel , Cairns Claire , Natrajan Rachael , Boult Jessica K.R. , Robinson Simon P. , Sill Martin , Dunkel Ira J. , Gilheeney Stephen W. , Rosenblum Marc K. , Hughes Debbie , Proszek Paula Z. , Macdonald Tobey J. , Preusser Matthias , Haberler Christine , Slavc Irene , Packer Roger , Ng Ho-Keung , Caspi Shani , Popović Mara , Faganel Kotnik Barbara , Wood Matthew D. , Baird Lissa , Davare Monika Ashok , Solomon David A. , Olsen Thale Kristin , Brandal Petter , Farrell Michael , Cryan Jane B. , Capra Michael , Karremann Michael , Schittenhelm Jens , Schuhmann Martin U. , Ebinger Martin , Dinjens Winand N.M. , Kerl Kornelius , Hettmer Simone , Pietsch Torsten , Andreiuolo Felipe , Driever Pablo Hernáiz , Korshunov Andrey , Hiddingh Lotte , Worst Barbara C. , Sturm Dominik , Zuckermann Marc , Witt Olaf , Bloom Tabitha , Mitchell Clare , Miele Evelina , Colafati Giovanna Stefania , Diomedi-Camassei Francesca , Bailey Simon , Moore Andrew S. , Hassall Timothy E.G. , Lowis Stephen P. , Tsoli Maria , Cowley Mark J. , Ziegler David S. , Karajannis Matthias A. , Aquilina Kristian , Hargrave Darren R. , Carceller Fernando , Marshall Lynley V. , von Deimling Andreas , Kramm Christof M. , Pfister Stefan M. , Sahm Felix , Baker Suzanne J. , Mastronuzzi Angela , Carai Andrea , Vinci Maria , Capper David , Popov Sergey , Ellison David W. , Jacques Thomas S. , Jones David T.W. , Jones Chris
Published: April 2023

Supplementary Table S5
Supplementary Data from Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
Authors: Erkes Dan A. , Cai Weijia , Sanchez Ileine M. , Purwin Timothy J. , Rogers Corey , Field Conroy O. , Berger Adam C. , Hartsough Edward J. , Rodeck Ulrich , Alnemri Emad S. , Aplin Andrew E.
Published: April 2023

Supplementary Figures and Legends.
Supplementary Table S1 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Authors: Clarke Matthew , Mackay Alan , Ismer Britta , Pickles Jessica C. , Tatevossian Ruth G. , Newman Scott , Bale Tejus A. , Stoler Iris , Izquierdo Elisa , Temelso Sara , Carvalho Diana M. , Molinari Valeria , Burford Anna , Howell Louise , Virasami Alex , Fairchild Amy R. , Avery Aimee , Chalker Jane , Kristiansen Mark , Haupfear Kelly , Dalton James D. , Orisme Wilda , Wen Ji , Hubank Michael , Kurian Kathreena M. , Rowe Catherine , Maybury Mellissa , Crosier Stephen , Knipstein Jeffrey , Schüller Ulrich , Kordes Uwe , Kram David E. , Snuderl Matija , Bridges Leslie , Martin Andrew J. , Doey Lawrence J. , Al-Sarraj Safa , Chandler Christopher , Zebian Bassel , Cairns Claire , Natrajan Rachael , Boult Jessica K.R. , Robinson Simon P. , Sill Martin , Dunkel Ira J. , Gilheeney Stephen W. , Rosenblum Marc K. , Hughes Debbie , Proszek Paula Z. , Macdonald Tobey J. , Preusser Matthias , Haberler Christine , Slavc Irene , Packer Roger , Ng Ho-Keung , Caspi Shani , Popović Mara , Faganel Kotnik Barbara , Wood Matthew D. , Baird Lissa , Davare Monika Ashok , Solomon David A. , Olsen Thale Kristin , Brandal Petter , Farrell Michael , Cryan Jane B. , Capra Michael , Karremann Michael , Schittenhelm Jens , Schuhmann Martin U. , Ebinger Martin , Dinjens Winand N.M. , Kerl Kornelius , Hettmer Simone , Pietsch Torsten , Andreiuolo Felipe , Driever Pablo Hernáiz , Korshunov Andrey , Hiddingh Lotte , Worst Barbara C. , Sturm Dominik , Zuckermann Marc , Witt Olaf , Bloom Tabitha , Mitchell Clare , Miele Evelina , Colafati Giovanna Stefania , Diomedi-Camassei Francesca , Bailey Simon , Moore Andrew S. , Hassall Timothy E.G. , Lowis Stephen P. , Tsoli Maria , Cowley Mark J. , Ziegler David S. , Karajannis Matthias A. , Aquilina Kristian , Hargrave Darren R. , Carceller Fernando , Marshall Lynley V. , von Deimling Andreas , Kramm Christof M. , Pfister Stefan M. , Sahm Felix , Baker Suzanne J. , Mastronuzzi Angela , Carai Andrea , Vinci Maria , Capper David , Popov Sergey , Ellison David W. , Jacques Thomas S. , Jones David T.W. , Jones Chris
Published: April 2023

Supplementary Table S1
Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Authors: Clarke Matthew , Mackay Alan , Ismer Britta , Pickles Jessica C. , Tatevossian Ruth G. , Newman Scott , Bale Tejus A. , Stoler Iris , Izquierdo Elisa , Temelso Sara , Carvalho Diana M. , Molinari Valeria , Burford Anna , Howell Louise , Virasami Alex , Fairchild Amy R. , Avery Aimee , Chalker Jane , Kristiansen Mark , Haupfear Kelly , Dalton James D. , Orisme Wilda , Wen Ji , Hubank Michael , Kurian Kathreena M. , Rowe Catherine , Maybury Mellissa , Crosier Stephen , Knipstein Jeffrey , Schüller Ulrich , Kordes Uwe , Kram David E. , Snuderl Matija , Bridges Leslie , Martin Andrew J. , Doey Lawrence J. , Al-Sarraj Safa , Chandler Christopher , Zebian Bassel , Cairns Claire , Natrajan Rachael , Boult Jessica K.R. , Robinson Simon P. , Sill Martin , Dunkel Ira J. , Gilheeney Stephen W. , Rosenblum Marc K. , Hughes Debbie , Proszek Paula Z. , Macdonald Tobey J. , Preusser Matthias , Haberler Christine , Slavc Irene , Packer Roger , Ng Ho-Keung , Caspi Shani , Popović Mara , Faganel Kotnik Barbara , Wood Matthew D. , Baird Lissa , Davare Monika Ashok , Solomon David A. , Olsen Thale Kristin , Brandal Petter , Farrell Michael , Cryan Jane B. , Capra Michael , Karremann Michael , Schittenhelm Jens , Schuhmann Martin U. , Ebinger Martin , Dinjens Winand N.M. , Kerl Kornelius , Hettmer Simone , Pietsch Torsten , Andreiuolo Felipe , Driever Pablo Hernáiz , Korshunov Andrey , Hiddingh Lotte , Worst Barbara C. , Sturm Dominik , Zuckermann Marc , Witt Olaf , Bloom Tabitha , Mitchell Clare , Miele Evelina , Colafati Giovanna Stefania , Diomedi-Camassei Francesca , Bailey Simon , Moore Andrew S. , Hassall Timothy E.G. , Lowis Stephen P. , Tsoli Maria , Cowley Mark J. , Ziegler David S. , Karajannis Matthias A. , Aquilina Kristian , Hargrave Darren R. , Carceller Fernando , Marshall Lynley V. , von Deimling Andreas , Kramm Christof M. , Pfister Stefan M. , Sahm Felix , Baker Suzanne J. , Mastronuzzi Angela , Carai Andrea , Vinci Maria , Capper David , Popov Sergey , Ellison David W. , Jacques Thomas S. , Jones David T.W. , Jones Chris
Published: April 2023

Supplementary Figures and Legends
Table S4 from Cell of Origin Influences Pancreatic Cancer Subtype
Authors: Flowers Brittany M. , Xu Hang , Mulligan Abigail S. , Hanson Kathryn J. , Seoane Jose A. , Vogel Hannes , Curtis Christina , Wood Laura D. , Attardi Laura D.
Published: April 2023

Acinar and ductal cell-derived tumor gene expression analysis
Supplementary Fig 5 from HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers
Authors: Li Bob T. , Michelini Flavia , Misale Sandra , Cocco Emiliano , Baldino Laura , Cai Yanyan , Shifman Sophie , Tu Hai-Yan , Myers Mackenzie L. , Xu Chongrui , Mattar Marissa , Khodos Inna , Little Megan , Qeriqi Besnik , Weitsman Gregory , Wilhem Clare J. , Lalani Alshad S. , Diala Irmina , Freedman Rachel A. , Lin Nancy U. , Solit David B. , Berger Michael F. , Barber Paul R. , Ng Tony , Offin Michael , Isbell James M. , Jones David R. , Yu Helena A. , Thyparambil Sheeno , Liao Wei-Li , Bhalkikar Anuja , Cecchi Fabiola , Hyman David M. , Lewis Jason S. , Buonocore Darren J. , Ho Alan L. , Makker Vicky , Reis-Filho Jorge S. , Razavi Pedram , Arcila Maria E. , Kris Mark G. , Poirier John T. , Shen Ronglai , Tsurutani Junji , Ulaner Gary A. , de Stanchina Elisa , Rosen Neal , Rudin Charles M. , Scaltriti Maurizio
Published: April 2023

Supplementary Fig 5
Table S2 from Cell of Origin Influences Pancreatic Cancer Subtype
Authors: Flowers Brittany M. , Xu Hang , Mulligan Abigail S. , Hanson Kathryn J. , Seoane Jose A. , Vogel Hannes , Curtis Christina , Wood Laura D. , Attardi Laura D.
Published: April 2023

Phenotypes in acinar cell-of-origin Trp53 missense mutation mouse cohorts
Table S1 from Cell of Origin Influences Pancreatic Cancer Subtype
Authors: Flowers Brittany M. , Xu Hang , Mulligan Abigail S. , Hanson Kathryn J. , Seoane Jose A. , Vogel Hannes , Curtis Christina , Wood Laura D. , Attardi Laura D.
Published: April 2023

Phenotypes in acinar cell-of-origin Trp53 wild-type, Trp53 heterozygous, and Trp53 knockout mouse cohorts
Figure S5 from Cell of Origin Influences Pancreatic Cancer Subtype
Authors: Flowers Brittany M. , Xu Hang , Mulligan Abigail S. , Hanson Kathryn J. , Seoane Jose A. , Vogel Hannes , Curtis Christina , Wood Laura D. , Attardi Laura D.
Published: April 2023

Acinar and ductal cell-derived tumor signature enrichment in TCGA cohort
Figure S4 from Cell of Origin Influences Pancreatic Cancer Subtype
Authors: Flowers Brittany M. , Xu Hang , Mulligan Abigail S. , Hanson Kathryn J. , Seoane Jose A. , Vogel Hannes , Curtis Christina , Wood Laura D. , Attardi Laura D.
Published: April 2023

Transcriptome and histological analysis of mouse acinar and ductal cell-derived tumors
Supplementary Figures from Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy
Authors: Nowicki Theodore S. , Farrell Colin , Morselli Marco , Rubbi Liudmilla , Campbell Katie M. , Macabali Mignonette H. , Berent-Maoz Beata , Comin-Anduix Begoña , Pellegrini Matteo , Ribas Antoni
Published: April 2023

Supplementary Figures and Figure Legends
Supplementary Table S1 from Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
Authors: Hobbs G. Aaron , Baker Nicole M. , Miermont Anne M. , Thurman Ryan D. , Pierobon Mariaelena , Tran Timothy H. , Anderson Andrew O. , Waters Andrew M. , Diehl J. Nathaniel , Papke Bjoern , Hodge Richard G. , Klomp Jennifer E. , Goodwin Craig M. , DeLiberty Jonathan M. , Wang Junning , Ng Raymond W.S. , Gautam Prson , Bryant Kirsten L. , Esposito Dominic , Campbell Sharon L. , Petricoin Emanuel F. , Simanshu Dhirendra K. , Aguirre Andrew J. , Wolpin Brian M. , Wennerberg Krister , Rudloff Udo , Cox Adrienne D. , Der Channing J.
Published: April 2023

Structure factors and crystal information
Supplementary Data S1-S7 from Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
Authors: Hobbs G. Aaron , Baker Nicole M. , Miermont Anne M. , Thurman Ryan D. , Pierobon Mariaelena , Tran Timothy H. , Anderson Andrew O. , Waters Andrew M. , Diehl J. Nathaniel , Papke Bjoern , Hodge Richard G. , Klomp Jennifer E. , Goodwin Craig M. , DeLiberty Jonathan M. , Wang Junning , Ng Raymond W.S. , Gautam Prson , Bryant Kirsten L. , Esposito Dominic , Campbell Sharon L. , Petricoin Emanuel F. , Simanshu Dhirendra K. , Aguirre Andrew J. , Wolpin Brian M. , Wennerberg Krister , Rudloff Udo , Cox Adrienne D. , Der Channing J.
Published: April 2023

All supplemental data with figure legends
Supplementary Figure S7 from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Authors: Chen Peiwen , Hsu Wen-Hao , Chang Andrew , Tan Zhi , Lan Zhengdao , Zhou Ashley , Spring Denise J. , Lang Frederick F. , Wang Y. Alan , DePinho Ronald A.
Published: April 2023

Figure S7 shows that CLOCK correlates positively with M2 microglia abundance in GBM.
Supplementary Figure S4 from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Authors: Chen Peiwen , Hsu Wen-Hao , Chang Andrew , Tan Zhi , Lan Zhengdao , Zhou Ashley , Spring Denise J. , Lang Frederick F. , Wang Y. Alan , DePinho Ronald A.
Published: April 2023

In Figure S4, Gene ontology enrichment analysis identifies the role of OLFML3, LGMN and LIPA in leukocyte/microglia migration.
Supplementary Figure S3 from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Authors: Chen Peiwen , Hsu Wen-Hao , Chang Andrew , Tan Zhi , Lan Zhengdao , Zhou Ashley , Spring Denise J. , Lang Frederick F. , Wang Y. Alan , DePinho Ronald A.
Published: April 2023

Figure S3 shows that CLOCK depletion impairs microglia migration.
Supplementary Figure S1 from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
Authors: Chen Peiwen , Hsu Wen-Hao , Chang Andrew , Tan Zhi , Lan Zhengdao , Zhou Ashley , Spring Denise J. , Lang Frederick F. , Wang Y. Alan , DePinho Ronald A.
Published: April 2023

Figure S1 shows that CLOCK/BMAL1 is essential for GSC self-­renewal, but not required for glioma cell proliferation.
Supplementary Tables. from Personalized Antibodies for Gastroesophageal Adenocarcinoma (PANGEA): A Phase II Study Evaluating an Individualized Treatment Strategy for Metastatic Disease
Authors: Catenacci Daniel V.T. , Moya Stephanie , Lomnicki Samantha , Chase Leah M. , Peterson Bryan F. , Reizine Natalie , Alpert Lindsay , Setia Namrata , Xiao Shu-Yuan , Hart John , Siddiqui Uzma D. , Hogarth D. Kyle , Eng Oliver S. , Turaga Kiran , Roggin Kevin , Posner Mitchell C. , Chang Paul , Narula Sunil , Rampurwala Murtuza , Ji Yuan , Karrison Theodore , Liao Chih-Yi , Polite Blase N. , Kindler Hedy L.
Published: April 2023

Supplementary tables.
Supplementary Table from Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19
Authors: Agarwal Sangya , June Carl H.
Published: April 2023

Examples of therapies used for HLH and MAS.
Supplementary Data Table S1 from Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response
Authors: Montesion Meagan , Murugesan Karthikeyan , Jin Dexter X. , Sharaf Radwa , Sanchez Nora , Guria Ameet , Minker Max , Li Gerald , Fisher Virginia , Sokol Ethan S. , Pavlick Dean C. , Moore Jay A. , Braly Alan , Singal Gaurav , Fabrizio David , Comment Leah A. , Rizvi Naiyer A. , Alexander Brian M. , Frampton Garrett M. , Hegde Priti S. , Albacker Lee A.
Published: April 2023

Characteristics of patients in the real-world clinico-genomic cohort
Supplementary Data Figure S3 from Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response
Authors: Montesion Meagan , Murugesan Karthikeyan , Jin Dexter X. , Sharaf Radwa , Sanchez Nora , Guria Ameet , Minker Max , Li Gerald , Fisher Virginia , Sokol Ethan S. , Pavlick Dean C. , Moore Jay A. , Braly Alan , Singal Gaurav , Fabrizio David , Comment Leah A. , Rizvi Naiyer A. , Alexander Brian M. , Frampton Garrett M. , Hegde Priti S. , Albacker Lee A.
Published: April 2023

Somatic HLA-I LOH is not significantly enriched in microsatellite instable samples
Supplementary Data Figure S1 from Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response
Authors: Montesion Meagan , Murugesan Karthikeyan , Jin Dexter X. , Sharaf Radwa , Sanchez Nora , Guria Ameet , Minker Max , Li Gerald , Fisher Virginia , Sokol Ethan S. , Pavlick Dean C. , Moore Jay A. , Braly Alan , Singal Gaurav , Fabrizio David , Comment Leah A. , Rizvi Naiyer A. , Alexander Brian M. , Frampton Garrett M. , Hegde Priti S. , Albacker Lee A.
Published: April 2023

HLA-I germline zygosity has no impact on patient survival in ICI-treated NSCLC
Supplementary Figures from Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Authors: Cremer Anjali , Ellegast Jana M. , Alexe Gabriela , Frank Elizabeth S. , Ross Linda , Chu S. Haihua , Pikman Yana , Robichaud Amanda , Goodale Amy , Häupl Björn , Mohr Sebastian , Rao Arati V. , Walker Alison R. , Blachly James S. , Piccioni Federica , Armstrong Scott A. , Byrd John C. , Oellerich Thomas , Stegmaier Kimberly
Published: April 2023

Fig. S1: Characterization of effects of Entospletinib in AML in vitro and in vivo, Fig. S2: Genome-scale lentiviral ORFeome library screen identifies drivers of entospletinib resistance in AML.; Fig. S3: Viability analysis with increasing concentrations of PRT062067; Fig. S4: Characterization of a MV4-11 cell line with acquired resistance to entospletinib; Fig. S5: PTPN11 mutants confer resistance to entospletinib in AML; Fig S6: Combination of a MEK-Inhibitor and a SYK-Inhibitor is synergistic in in vitro AML models; Fig. S7: Combination of a MEK inhibitor and a SYK inhibitor shows no toxicity in healthy mice
Supplementary Movie from Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
Authors: Song Xinxin , Zhou Zhuan , Li Hongchun , Xue Yifan , Lu Xinghua , Bahar Ivet , Kepp Oliver , Hung Mien-Chie , Kroemer Guido , Wan Yong
Published: April 2023

Movie S. AMFR RING (cyan) and B7-H4 dimer complex in 120 ns MD simulations (run 1). Simulations were performed to verify the stability of the complex conformer illustrated in Fig. 4E. B7-H4 Ig-like V-type 1 and Ig-like V-type 2 domains are in pale green and green. Ubiquitination sites (K138 and K146) are highlighted in blue spheres. Asparagines are shown in orange sticks. Interacting residues between the two proteins are represented as CPK and colored by atom types.
CD-19-1510R1_Supplementary_Appendix.docx from Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)
Authors: Diab Adi , Tannir Nizar M. , Bentebibel Salah-Eddine , Hwu Patrick , Papadimitrakopoulou Vassiliki , Haymaker Cara , Kluger Harriet M. , Gettinger Scott N. , Sznol Mario , Tykodi Scott S. , Curti Brendan D. , Tagliaferri Mary A. , Zalevsky Jonathan , Hannah Alison L. , Hoch Ute , Aung Sandra , Fanton Christie , Rizwan Ahsan , Iacucci Ernesto , Liao Yijie , Bernatchez Chantale , Hurwitz Michael E. , Cho Daniel C.
Published: April 2023

Consolidated supplementary appendix: tables, figures, text plus legends
Supplementary Table 2 from Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition
Authors: Schatoff Emma M. , Goswami Sukanya , Zafra Maria Paz , Foronda Miguel , Shusterman Michael , Leach Benjamin I. , Katti Alyna , Diaz Bianca J. , Dow Lukas E.
Published: April 2023

TPM data for 18 WNT target genes
Supplementary Figures from Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition
Authors: Schatoff Emma M. , Goswami Sukanya , Zafra Maria Paz , Foronda Miguel , Shusterman Michael , Leach Benjamin I. , Katti Alyna , Diaz Bianca J. , Dow Lukas E.
Published: April 2023

Supplementary Figures 1-14
Supplementary Data from Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
Authors: Parkhurst Maria R. , Robbins Paul F. , Tran Eric , Prickett Todd D. , Gartner Jared J. , Jia Li , Ivey Gabriel , Li Yong F. , El-Gamil Mona , Lalani Almin , Crystal Jessica S. , Sachs Abraham , Groh Eric , Ray Satyajit , Ngo Lien T. , Kivitz Scott , Pasetto Anna , Yossef Rami , Lowery Frank J. , Goff Stephanie L. , Lo Winifred , Cafri Gal , Deniger Drew C. , Malekzadeh Parisa , Ahmadzadeh Mojgan , Wunderlich John R. , Somerville Robert P.T. , Rosenberg Steven A.
Published: April 2023

Supplementary Materials and Methods
Supplementary Data from Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
Authors: Parkhurst Maria R. , Robbins Paul F. , Tran Eric , Prickett Todd D. , Gartner Jared J. , Jia Li , Ivey Gabriel , Li Yong F. , El-Gamil Mona , Lalani Almin , Crystal Jessica S. , Sachs Abraham , Groh Eric , Ray Satyajit , Ngo Lien T. , Kivitz Scott , Pasetto Anna , Yossef Rami , Lowery Frank J. , Goff Stephanie L. , Lo Winifred , Cafri Gal , Deniger Drew C. , Malekzadeh Parisa , Ahmadzadeh Mojgan , Wunderlich John R. , Somerville Robert P.T. , Rosenberg Steven A.
Published: April 2023

Supplementary Table 1
Supplementary Data from A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors
Authors: Bentebibel Salah-Eddine , Hurwitz Michael E. , Bernatchez Chantale , Haymaker Cara , Hudgens Courtney W. , Kluger Harriet M. , Tetzlaff Michael T. , Tagliaferri Mary A. , Zalevsky Jonathan , Hoch Ute , Fanton Christie , Aung Sandra , Hwu Patrick , Curti Brendan D. , Tannir Nizar M. , Sznol Mario , Diab Adi
Published: April 2023

Supplementary Figures, Tables, and Methods
Table S2 from Lineage Reversion Drives WNT Independence in Intestinal Cancer
Authors: Han Teng , Goswami Sukanya , Hu Yang , Tang Fanying , Zafra Maria Paz , Murphy Charles , Cao Zhen , Poirier John T. , Khurana Ekta , Elemento Olivier , Hechtman Jaclyn F. , Ganesh Karuna , Yaeger Rona , Dow Lukas E.
Published: April 2023

Oligonucleotides
Table S9 from Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E.
Published: April 2023

sc-RNAseq
Table S6 from Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E.
Published: April 2023

Gene expression
Table S5 from Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E.
Published: April 2023

Genomic regulatory regions in young HSCe
Table S3 from Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E.
Published: April 2023

Differentially methylated regions
Table S2 from Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E.
Published: April 2023

Differential ChIP-seq peaks
Table S10 from Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E.
Published: April 2023

Regions predisposing to AML
Figure S4 from RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon
Authors: Yu Johnny , Navickas Albertas , Asgharian Hosseinali , Culbertson Bruce , Fish Lisa , Garcia Kristle , Olegario John Paolo , Dermit Maria , Dodel Martin , Hänisch Benjamin , Luo Yikai , Weinberg Ethan M. , Dienstmann Rodrigo , Warren Robert S. , Mardakheh Faraz K. , Goodarzi Hani
Published: April 2023

Supplementary Figure 4
Figure S3 from RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon
Authors: Yu Johnny , Navickas Albertas , Asgharian Hosseinali , Culbertson Bruce , Fish Lisa , Garcia Kristle , Olegario John Paolo , Dermit Maria , Dodel Martin , Hänisch Benjamin , Luo Yikai , Weinberg Ethan M. , Dienstmann Rodrigo , Warren Robert S. , Mardakheh Faraz K. , Goodarzi Hani
Published: April 2023

Supplementary Figure 3
Supplementary Data from V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer
Authors: Gao Yijun , Maria Ann , Na Na , da Cruz Paula Arnaud , Gorelick Alexander N. , Hechtman Jaclyn F. , Carson Julianne , Lefkowitz Robert A. , Weigelt Britta , Taylor Barry S. , Zhao HuiYong , Reis-Filho Jorge S. , de Stanchina Elisa , Rosen Neal , Yao Zhan , Yaeger Rona
Published: April 2023

supplementary tables, figures, and methods
Supplementary Data from Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer
Authors: Farago Anna F. , Yeap Beow Y. , Stanzione Marcello , Hung Yin P. , Heist Rebecca S. , Marcoux J. Paul , Zhong Jun , Rangachari Deepa , Barbie David A. , Phat Sarah , Myers David T. , Morris Robert , Kem Marina , Dubash Taronish D. , Kennedy Elizabeth A. , Digumarthy Subba R. , Sequist Lecia V. , Hata Aaron N. , Maheswaran Shyamala , Haber Daniel A. , Lawrence Michael S. , Shaw Alice T. , Mino-Kenudson Mari , Dyson Nicholas J. , Drapkin Benjamin J.
Published: April 2023

Supplementary Tables and Figures
Table S2 from Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer
Authors: Pennycuick Adam , Teixeira Vitor H. , AbdulJabbar Khalid , Raza Shan E. Ahmed , Lund Tom , Akarca Ayse U. , Rosenthal Rachel , Kalinke Lukas , Chandrasekharan Deepak P. , Pipinikas Christodoulos P. , Lee-Six Henry , Hynds Robert E. , Gowers Kate H.C. , Henry Jake Y. , Millar Fraser R. , Hagos Yeman B. , Denais Celine , Falzon Mary , Moore David A. , Antoniou Sophia , Durrenberger Pascal F. , Furness Andrew J. , Carroll Bernadette , Marceaux Claire , Asselin-Labat Marie-Liesse , Larson William , Betts Courtney , Coussens Lisa M. , Thakrar Ricky M. , George Jeremy , Swanton Charles , Thirlwell Christina , Campbell Peter J. , Marafioti Teresa , Yuan Yinyin , Quezada Sergio A. , McGranahan Nicholas , Janes Sam M.
Published: April 2023

Markers used to define cell types in quantitative multiplex immunohistochemistry experiments.
Table S1 from Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer
Authors: Pennycuick Adam , Teixeira Vitor H. , AbdulJabbar Khalid , Raza Shan E. Ahmed , Lund Tom , Akarca Ayse U. , Rosenthal Rachel , Kalinke Lukas , Chandrasekharan Deepak P. , Pipinikas Christodoulos P. , Lee-Six Henry , Hynds Robert E. , Gowers Kate H.C. , Henry Jake Y. , Millar Fraser R. , Hagos Yeman B. , Denais Celine , Falzon Mary , Moore David A. , Antoniou Sophia , Durrenberger Pascal F. , Furness Andrew J. , Carroll Bernadette , Marceaux Claire , Asselin-Labat Marie-Liesse , Larson William , Betts Courtney , Coussens Lisa M. , Thakrar Ricky M. , George Jeremy , Swanton Charles , Thirlwell Christina , Campbell Peter J. , Marafioti Teresa , Yuan Yinyin , Quezada Sergio A. , McGranahan Nicholas , Janes Sam M.
Published: April 2023

Details of molecular investigations performed on each sample. Clinical and outcome data is also presented. In all cases with a previous history of lung cancer, this was of squamous histology.
Supplementary Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Authors: Grunewald Susanne , Klug Lillian R. , Mühlenberg Thomas , Lategahn Jonas , Falkenhorst Johanna , Town Ajia , Ehrt Christiane , Wardelmann Eva , Hartmann Wolfgang , Schildhaus Hans-Ulrich , Treckmann Juergen , Fletcher Jonathan A. , Jung Sascha , Czodrowski Paul , Miller Stephen , Schmidt-Kittler Oleg , Rauh Daniel , Heinrich Michael C. , Bauer Sebastian
Published: April 2023

Contains: Supplemental Figures 1-7; Supplemental Tables 1 -3; Supplemental Methods
Supplementary Figures S1-S4; Supplementary Tables S1-S4 from Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer
Authors: Coates James T. , Sun Sheng , Leshchiner Ignaty , Thimmiah Nayana , Martin Elizabeth E. , McLoughlin Daniel , Danysh Brian P. , Slowik Kara , Jacobs Raquel A. , Rhrissorrakrai Kahn , Utro Filippo , Levovitz Chaya , Denault Elyssa , Walmsley Charlotte S. , Kambadakone Avinash , Stone James R. , Isakoff Steven J. , Parida Laxmi , Juric Dejan , Getz Gad , Bardia Aditya , Ellisen Leif W.
Published: April 2023

Figure S1, radiographic assessment of key lesions of patient MGH-18; Figure S2, supplementary genomic analysis for patient MGH-18; Figure S3, supporting data for mechanism of TROP2 T256R; Figure S4, TROP2 immunohistochemistry for metastatic lesions of MGH-18; Table S1, detailed cohort characteristics; Table S2, patient treatment histories; Table S3, supplementary mutational data for MGH-18; Table S4, antibodies used.
Supplementary Data from Splicing Patterns in SF3B1-Mutated Uveal Melanoma Generate Shared Immunogenic Tumor-Specific Neoepitopes
Authors: Bigot Jeremy , Lalanne Ana I. , Lucibello Francesca , Gueguen Paul , Houy Alexandre , Dayot Stephane , Ganier Olivier , Gilet Jules , Tosello Jimena , Nemati Fariba , Pierron Gaelle , Waterfall Joshua J. , Barnhill Raymond , Gardrat Sophie , Piperno-Neumann Sophie , Popova Tatiana , Masson Vanessa , Loew Damarys , Mariani Pascale , Cassoux Nathalie , Amigorena Sebastian , Rodrigues Manuel , Alsafadi Samar , Stern Marc-Henri , Lantz Olivier
Published: April 2023

Supplementary Data from Splicing Patterns in SF3B1-Mutated Uveal Melanoma Generate Shared Immunogenic Tumor-Specific Neoepitopes
Figure S5 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Authors: Liudahl Shannon M. , Betts Courtney B. , Sivagnanam Shamilene , Morales-Oyarvide Vicente , da Silva Annacarolina , Yuan Chen , Hwang Samuel , Grossblatt-Wait Alison , Leis Kenna R. , Larson William , Lavoie Meghan B. , Robinson Padraic , Dias Costa Andressa , Väyrynen Sara A. , Clancy Thomas E. , Rubinson Douglas A. , Link Jason , Keith Dove , Horton Wesley , Tempero Margaret A. , Vonderheide Robert H. , Jaffee Elizabeth M. , Sheppard Brett , Goecks Jeremy , Sears Rosalie C. , Park Byung S. , Mori Motomi , Nowak Jonathan A. , Wolpin Brian M. , Coussens Lisa M.
Published: April 2023

Figure S5 is related to Figure 5. It shows multiple metrics of intrapatient heterogeneity based on size and histopathology type of assessed tissue.
Figure S3 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Authors: Liudahl Shannon M. , Betts Courtney B. , Sivagnanam Shamilene , Morales-Oyarvide Vicente , da Silva Annacarolina , Yuan Chen , Hwang Samuel , Grossblatt-Wait Alison , Leis Kenna R. , Larson William , Lavoie Meghan B. , Robinson Padraic , Dias Costa Andressa , Väyrynen Sara A. , Clancy Thomas E. , Rubinson Douglas A. , Link Jason , Keith Dove , Horton Wesley , Tempero Margaret A. , Vonderheide Robert H. , Jaffee Elizabeth M. , Sheppard Brett , Goecks Jeremy , Sears Rosalie C. , Park Byung S. , Mori Motomi , Nowak Jonathan A. , Wolpin Brian M. , Coussens Lisa M.
Published: April 2023

Figure S3 is related to Figure 3 and shows comparisons of leukocyte densities between treatment-naive PDACS from Cohort 1 and Cohort 2, shows leukocyte subpopulations whose density most strongly correlates to total leukocyte density within PDACs, and shows patient overall survival based on total leukocyte density in tumor and adjacent stroma.
Supplementary Figure S6 from Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer
Authors: Malone Clare F. , Dharia Neekesh V. , Kugener Guillaume , Forman Alexandra B. , Rothberg Michael V. , Abdusamad Mai , Gonzalez Alfredo , Kuljanin Miljan , Robichaud Amanda L. , Conway Amy Saur , Dempster Joshua M. , Paolella Brenton R. , Dumont Nancy , Hovestadt Volker , Mancias Joseph D. , Younger Scott T. , Root David E. , Golub Todd R. , Vazquez Francisca , Stegmaier Kimberly
Published: April 2023

NXT2 expression is not associated with neuroblastoma disease subtypes
Table S4 from Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy
Authors: Pelly Victoria S. , Moeini Agrin , Roelofsen Lisanne M. , Bonavita Eduardo , Bell Charlotte R. , Hutton Colin , Blanco-Gomez Adrian , Banyard Antonia , Bromley Christian P. , Flanagan Eimear , Chiang Shih-Chieh , Jørgensen Claus , Schumacher Ton N. , Thommen Daniela S. , Zelenay Santiago
Published: April 2023

Table S4
Figure S6 from ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Authors: Arabzade Amir , Zhao Yanhua , Varadharajan Srinidhi , Chen Hsiao-Chi , Jessa Selin , Rivas Bryan , Stuckert Austin J. , Solis Minerva , Kardian Alisha , Tlais Dana , Golbourn Brian J. , Stanton Ann-Catherine J. , Chan Yuen San , Olson Calla , Karlin Kristen L. , Kong Kathleen , Kupp Robert , Hu Baoli , Injac Sarah G. , Ngo Madeline , Wang Peter R. , De León Luz A. , Sahm Felix , Kawauchi Daisuke , Pfister Stefan M. , Lin Charles Y. , Hodges H. Courtney , Singh Irtisha , Westbrook Thomas F. , Chintagumpala Murali M. , Blaney Susan M. , Parsons Donald W. , Pajtler Kristian W. , Agnihotri Sameer , Gilbertson Richard J. , Yi Joanna , Jabado Nada , Kleinman Claudia L. , Bertrand Kelsey C. , Deneen Benjamin , Mack Stephen C.
Published: April 2023

Figure S6 to show up-regulation of the NF-kB pathway in ZRfus IUE tumors
Supplementary Methods from Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing
Authors: Sinjab Ansam , Han Guangchun , Treekitkarnmongkol Warapen , Hara Kieko , Brennan Patrick M. , Dang Minghao , Hao Dapeng , Wang Ruiping , Dai Enyu , Dejima Hitoshi , Zhang Jiexin , Bogatenkova Elena , Sanchez-Espiridion Beatriz , Chang Kyle , Little Danielle R. , Bazzi Samer , Tran Linh M. , Krysan Kostyantyn , Behrens Carmen , Duose Dzifa Y. , Parra Edwin R. , Raso Maria Gabriela , Solis Luisa M. , Fukuoka Junya , Zhang Jianjun , Sepesi Boris , Cascone Tina , Byers Lauren Averett , Gibbons Don L. , Chen Jichao , Moghaddam Seyed Javad , Ostrin Edwin J. , Rosen Daniel , Heymach John V. , Scheet Paul , Dubinett Steven M. , Fujimoto Junya , Wistuba Ignacio I. , Stevenson Christopher S. , Spira Avrum , Wang Linghua , Kadara Humam
Published: April 2023

Supplementary Methods