bluuebunny/crossref_metadata_2025 huggingface dataset:
QUELS SONT LES FACTEURS PREDICTIFS DECHEC DU TRAITEMENT ENDOSCOPIQUE DES ULCERES HEMORRAGIQUES?
Authors: Figuigui Mouna , Abid Hakima , Lamine Asmae , Lahlali Maria , Lahmidani Nada , El Yousfi Mounia , Adil Ibrahimi Sidi , El Abkari Mohammed , Benajah Dafr-Allah
Published: April 2022

Ulcerative gastrointestinal bleeding is the most frequent emergency in digestive endoscopy. Management is based on the initiation of an infusion of proton pump inhibitors as soon as the diagnosis is mentioned. Upper endoscopy should be performed as quickly as possible under the best technical conditions. Two combined techniques of endoscopic hemostasis, most often by injection of reduced adrenaline and placement of clips, allow hemostasis in most situations. In case of failure, a new endoscopy can be proposed. Surgery and interventional radiology have a place in second or even third line treatment. A retrospective study was carried out on 80 patients over an extended period from 2009 to 2019. Including all patients presented to the emergency department for upper gastrointestinal bleeding regardless of the mode of exteriorization and who were reinforced with endoscopic treatment. risk of surgery and death. The objective of our work is to evaluate the effectiveness of endoscopic management and to deduce the predictive factors of failure of endoscopic hemostasis.
AN OBSERVATIONAL STUDY ON DIASTOLIC FUNCTION IN POST MYOCARDIAL INFARCTION PATIENTS IN A TERTIARY CARE CENTRE IN KANCHEEPURAM DISTRICT
Authors: Sivakumar Akshara , Kulothungan R.
Published: April 2022

Background: Diastolic dysfunction may be the earliest marker which leads to progressive cardiac failure. Thus the importance of detecting diastolic dysfunction using tissue doppler echocardiography helps in preventing the progression of patients to symptomatic congestive cardiac failure Objectives: 1. To find the prevalence of diastolic dysfunction in post myocardial infarction patients 2. To study the association between left ventricular diastolic dysfunction and variables such as smoking, Diabetes, Hypertension, Killip class,Type of Myocardial Infarction Methodology: Study design: Cross sectional study Study population : Post Myocardial infarction patients between 30 to 60 years of age Study period :18 months Sample size :144 Sampling technique :Convenient sampling Results:Prevalence of left ventricular diastolic dysfunction is 56%.There is statistically significant association between risk factors like smoking ,hypertension ,diabetes and occurrence of left ventricular diastolic dysfunction(P<0.05).There is no association between type of Myocardial infarction and left ventricular diastolic dysfunction . Conclusion: Worsening diastolic function can be detected even in apparently healthy persons. Although confirmation in other studies would be helpful, our data suggest that persistence or progression of diastolic dysfunction is a risk factor for heart failure in post myocardial infarction patients.
CURING AND DEGRADATION BEHAVIOR OF VINYL ESTERS OF CYCLOALIPHATIC EPOXY RESINS
Authors:   Assistant Professor Department of Chemistry D.S.N. PG College Unnao., Srivastava Akanksha
Published: April 2022

Curing and degradation behavior of two unsaturated esters based on cycloaliphatic epoxy resin containing glycidyl epoxy group (C1E) and epoxy cyclohexane group (C2E)were studied using DSC and TGA Techniques. DSC thermograms of ester C1E and C2E mixed with reactive styrene (40% w/w) and initiator benzoyl peroxide (2%) shows that the curing of ester C2E takes place at higher temperature range in comparison to C1E due to their dense rigid structure. The degradation behavior of cured esters are studied using thermal analyst 2000 equipped with 2950 thermal gravimetric analysis at heating rate 100C min-1. The TG and DTG thermogram of both esters show single step degradation. The temperature of 1-10% weight loss for both ester was studied from TGA. Thethermal stability of the ester C2E was found to be higher than that of C1E.
ASSESSMENT OF THE USE OF COMPLEMENTARY MEDICINE AMONG DIABETIC PATIENTS ATTENDING DIABETIC CENTER IN AL-MADINAH
Authors: Kareem Al-Jedani Mohammed , Mohammed Abdulhakeem Muneer , Mohammed Abdulhakeem Mutaz
Published: April 2022

Background: Diabetes affects approximately 442 million people globally, with the majority living in low- and middle-income nations. Diabetes affects 34.1% of Saudi Arabian men and 27.6% of Saudi Arabian women. More than 400 natural diabetic therapies have been reported around the world. In Saudi Arabia, 45% of individuals use medicinal plants. The goal of our study was to see how often diabetic patients in Al-diabetic Madinahs centers used supplementary medicine. Methods: This was a descriptive cross-sectional study carried out in the city of Al-Madinah. In 2020, all adult diabetic patients of both genders who visited the diabetic center in Al-Madinah were included. EPI Info was used to compute the sample size, which was 384. Results: In this study, 362 diabetic patients were enrolled, with 193 (53.3%) of them being female and the remainder being male. The participants ranged in age from 30 to 85 years old, with a mean age of 45.25Â±12.47 years. Saudi citizens made up the vast bulk of the 332 participants (91.7% ). Herbal medicine was not widely used in the previous year, with only 53 people (14.6%) claiming to have used it. Many different types of herbs were utilized, , with Cinnamon 21(39.6%) being the most popular. Patients who utilized herbs based on a friends recommendation made up 54.7 % of the sample, while those who got them from a traditional healer made up 11.3 %. Surprisingly, 73.6 % of herb users did not tell their doctor they were using herbs. More than 88.7% of the patients said they would like to use herbs again. When the use of herbs was evaluated in relation to patient demographic features and disease status, there were no statistically significant associations between age, sex, nationality, location of residence, patient education, blood sugar control, diabetes mellitus duration, and herb use. Conclusion: Herbal medicine was not commonly used by diabetes individuals in our study. Cinnamon was the most often used spice among people who utilized it. Saudi nationality and the absence of complications were found to be strong predictors of diabetes patients usage of supplementary medicines. The government and health-care professionals should be aware of the potential benefits and hazards of herbal medication in diabetic patients. Patients with diabetes should be informed about the risks and advantages of herbal therapy.
THE RELEVANCE AND IMPORTANCE OF TUMOR INFILTRATING LYMPHOCYTES (TILS) IN BREAST CANCER
Authors:   Assistant Professor Of Pathology, Govt. Mohan Kumaramangalam Medical College, Salem., Suganya U. , Manibarathi R. ,   Assistant Professor Of Pathology, Govt. Karur Medical College, Karur., Suganthi C. ,   Assistant Profeesor Of Pathology ,Govt. Dharmapuri Medical College, Dharmapuri.
Published: April 2022

Tumor infiltrating lymphocytes (TILs) were evaluated in many cancers like ovarian tumors, endometrial tumors, colon cancer and melanoma. Now there is increasing trend in evaluating TILs in breast cancer. Tumor infiltrating lymphocytes gives the patients immune response to the tumor. 100 cases of Modified radical mastectomy specimen were chosen from surgical pathology records. The representative formalin fixed paraffin embedded tissue samples were collected. Detailed history regarding Patients age, sex, side of the breast involved , Grade and neoadjuvant chemotherapy were assessed for 100 cases. Tumor Infiltrating Lymphocytes are evaluated with Immuno HistoChemistry CD45 and CD3 for 100 cases , in which 93% cases were Infiltrating Ductal carcinoma-NOS cases and 07 % cases are of special types like Mucinous, Metaplastic, Apocrine, and Medullary carcinoma. Results: In our study, Highest incidence of breast carcinoma occur in the age group of 41-50 years. Infiltrating Ductal Carcinoma NOS is the most common primary malignant neoplasm of breast constituting 93% of cases. Most of the malignant tumors are left sided. Forty seven percent of cancers are presented in the size range of 2-5cms. Majority of the tumors are of Grade II accounting for 63.5% of all cases. TILs were evaluated with three variables 0- 10 % 20- 40 % and 50- 90 %.Younger the age, more the TILs. Neo adjuvant chemotherapy had significant correlation with TILs (P= 0.05).
EFFECTIVENESS OF AUDIOVISUAL DISTRACTION IN REDUCING ANXIETY AMONG HOSPITALIZED PRESCHOOL CHILDREN ADMITTED TO SELECTED TERTIARY CARE HOSPITAL IN, BELAGAVI CITY
Authors: Dewan Suvechhya , Thapa Nisha , Gauro Pooja
Published: April 2022

Background:Children between the ages of 3 and 6 years old are preschoolers. During the preschool phase, biological, psychosocial, emotional, moral, and social accomplishments are integrated. Preschoolers are pre-operational thinkers who believe in tangible presentation rather than concepts. Therefore, medical instruments and the hospital environment cause anxiety in them. Hospital admission is a traumatic event for both kids and adults, who unexpectedly have to abandon their comfortable residence and the people who are precious to them and avoid their enjoyable pastimes. Aim:This study aims to assess the effectiveness of audiovisual distraction in reducing hospitalization anxiety. Methods: This study used a pre-experimental (one group pretest-posttest) research design. Fifty preschoolers were selected using a non-probability convenient sampling technique. Anxiety was, evaluated using the Visual Analogue Scale for anxiety. Results:During the pretest, 60% of children had severe anxiety, 40% had mild anxiety after the audiovisual distraction, 62% had no anxiety, and 38% had mild anxiety. The mean anxiety level in the pretest score was 6.88, and the post-test score was 3.14, and the P-value was <0.0001. Findings revealed that audiovisual distraction effectively reduces the level of anxiety among hospitalized preschoolers. History and duration of the previous hospitalization have a significant association with the level of anxiety. Conclusions: Audiovisual distraction is effective in reducing anxiety among hospitalized preschoolers.
RISK MANAGEMENT RELATED TO THE PRESENCE OF LEAD IN DRINKING WATER: A LITERATURE REVIEW
Authors:   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Wartiti Mohammed Adnane El , Wafaa Enneffah ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Mustapha Bouatia ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Jaoudi Rachid El ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., El Cadi Mina Ait ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Yassir Bousliman ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco.
Published: April 2022

Background: Lead is classified as a toxic element because of its adverse health effects. World Health Organization fixes its tolerance limit at 10Î¼g/l. Lead in drinking water mainly comes from the dissolution of lead present in pipes, especially in old buildings. Resources and procedures: Through a literature review, we analyzed articles dealing with lead intoxication through drinking water. Used key words for the search were: lead, water and lead intoxication. The aim is to focus on the causes of this intoxication, the different consequences on the body, the standards in use and the prophylactic measures regarding this toxic element. Results and comments: Saturnism is a disease corresponding to acute or chronic lead intoxication. Once absorbed, lead diffuse rapidly in soft tissues and more slowly in the skeleton. Lead presents a cumulative toxicity with generalized effects, classified in group IIIB. Screening is based on blood lead levels, induced lead poisoning or radiology exams. Treatment is based on lead fixation in a non-toxic form and its elimination under methodical control. Water pollution comes from natural or anthropogenic origins and several methods and tips can reduce the risk of lead exposure. The most common technique for the determination of lead is inductively coupled plasma atomic emission spectrometry. Conclusion: In order to reduce as much as possible the risks linked to lead water pollution, it is essential to raise awareness of all stakeholders on the risks related to lead exposition and to sensitize them about preventive measures to be implemented.
PEMPHIGOID GESTATIONIS : CASE REPORT AND REVIEW OF LITTERATURE
Authors:   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco., Safae Badsi , Fatima Zahra Louzali ,   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco., Nisrine Benaouicha ,   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco., Najia Zeraidi ,   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco., Amina Lakhdar ,   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco., Aicha Kherbache ,   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco., Aziz Baidada ,   Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V and Rabat, Morocco.
Published: April 2022

Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis associated with pregnancy. Its previous designation, herpes gestationis, is obsolete. PG is characterized by a subepidermic separation induced by the presence of peripheral blood autoantibodies against two hemidesmosomal antigens: BPAG1 and BPAG2. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence tests. The most discriminant examination for other pruritic dermatoses of pregnancy is the enzyme-linked immunosorbent assay (Elisa) NC16A BP 180. First-line treatment is local corticosteroid therapy if local treatment fails, general corticosteroid therapy should be administered. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Management in a specialized setting is therefore necessary. Recurrence is possible during subsequent pregnancies. We report a case of PG identified in our department, with a review of literature about physiopathology, diagnosis and treatment of this rare pathology.
THEPREVALENCE OF ENERGY DRINKS AND ADVERSE EFFECT AMONG MALE STUDENTS IN TECHNICAL AND VOCATIONAL TRAINING CORPORATION (SAUDI ARABIA) IN AL-MADINAH AL-MUNAWARA REGION IN 2021
Authors:   Family Medicine Resident., Eid Alraddadi Husain
Published: April 2022

Background:There are so many adverse effects of consuming energy drinks, because of high amount of caffeine like increasing heart rate and blood pressure. Energy drink sales are rarely regulated by age and no roles in selling it unlike tobacco. Also, the prevalence of energy drinks consumption progressively increases in Saudi Arabia. This study aims to estimate the Prevalence of energy drinks and adverse effect among Male students in Technical and Vocational Training Corporation (Saudi Arabia) in Al-Madinah Al-Munawara Region in 2021. The study also aims to determine the Prevalence of energy drinks and adverse effect among Male students, to assess the association of energy drinks consumption and harmful effects (headache, insomnia and palpitation) among male students, and to find out the reason of Energy Drinks consumption among male students at Taibah university in Al-Madinah Al-Munawara in 2021. Methodology: This is a cross-sectional study conducted at Technical and Vocational Training Corporation (Saudi Arabia) in Al-Madinah Al-Munawara Region in 2021 to see the prevalence and adverse effects of energy drinks among male college students between March 2021 and august 2021.Analyses were conducted using Statistics SPSS 23.0 for windows (SPSS Inc., Chicago, IL, USA). Quantitative data were presented as the mean Â± SD & (range), and qualitative data were expressed as absolute frequencies (number) & relative frequencies (percentage). Results:Out of the invited 377 students, only 373 students filled and returned the questionnaire with a response rate of 99%. Fifty-nine-point two percent (59.2%) aged between 20- 25 years old, 31.9% were less than 20 years old and 5.6% were 26- 30 years old. 36.5% were specialized in network system management. More than two -third of the studied student(71%) drink one to three energy drink packs per week, while the other one-third is distributed between other categories(11.6% drink 4- 6 packs, 6% 7- 9 packs 3.6% 10- 12 packs, 1.5% 13- 15 packs and 3% more than 15 packs per week). Favourite type of energy drink was reported as 71.9% Code red, 21.3% Red bull, 21% Bison, and 11.7% power horse. Reasons for consuming energy drinks was because of its delicious taste in 80.5%, feeling of activism in 29.9%, to reduce fatigue and compensate for lost energy in 14.7%, to drive better in 9.6%, because of effect of advertising and commercials in 2.4%, and to imitate friends in 3.9%. Conclusion:Energy drink consumption is high among male students in Technical and Vocational Training Corporation (Saudi Arabia) in Al-Madinah Al-Munawara, Saudi Arabia. The rate of consumption is significantly associated with academic year.
PREVENTION OF DEEP VENOUS THROMBOSIS IN POST-OPERATIVE ARTHROPLASTY PATIENTS WITHOUT USE OF ANTICOAGULANT THERAPY
Authors: C. Supe Amit , P. Pande Kartik , A. Mhatre Jayesh
Published: April 2022

Background: Deep vein thrombosis (DVT) is one of the most common complications of total hip (THA) and total knee arthroplasty (TKA), mostly due to immobilisation and to some extent due to pre-existing co-morbidities along with genetic predisposition. Though the reported incidence of DVT is very high in multiple studies, fatal thromboembolism is very rarely seen in clinical setup. Hence the issue of prophylaxis for DVT remains highly debated1. The incidence of DVT is largely based on various studies in European and American populations. Asian population is genetically and socially quite different from American and European populations, so the incidence of DVT can be quite different2. We conducted a retrospective study at our centre to determine incidence of DVT after THA and TKA in Indian patients. Methods: A retrospective study was conducted on in 45 patients and who underwent THA and TKA respectively, without any known risk factors for thromboembolic disease. No prophylaxis was given to the patients. The patients were monitored in the post op period for any signs and symptoms of DVT along with starting of adequate physiotherapy Results: DVT was found in one patient who had undergone THA, which was confirmed on colour Doppler ultrasonography of the affected limb. No case of DVT was detected in any patient who had undergone TKA. Conclusion: These results suggest that the incidence of DVT in patients is very low and is not comparable when adequate postoperative mobilisation and physiotherapy was done.We conclude that advising prophylactic anticoagulant therapy to these patients in the post op period could be successfully substituted by a simple and cost effective but adequate physiotherapy prevent DVT, in the process also bypassing the side effects of the anticoagulant therapy.
MULTIDISCIPLINARY COLLABORATION THE GOLD STANDARD OF MEDICAL PRACTICE
Authors:   PhD Assistant Professor, Titu Maiorescu University - Faculty of Medicine, Bucharest, Romania Memormed Medical Center - Bucharest, Romania., Neagoe Mariana-Alis
Published: April 2022

The success of the medical act depends on a team approach to the patient. The multidisciplinary approach has a key role in diagnosing and treating the disease, in decreasing mortality and morbidity, increasing the patients quality of life. We present the case of a 58-year-old right-handed female patient known to have stage IIIB operated, chemo- and radio treated left breast neoplasm and operated left fronto-parietal brain tumor (adenocarcinoma metastasis). Approximately 4 months after the intervention, the patient presents an epileptic seizure, predominantly motor dysphasia and slight right brachial paresis. Brain computed tomography (CT) and magnetic resonance imaging (MRI) scan leftfronto-parietal tumor recurrence. Neurosurgical intervention is decided and subtotal ablation of the tumour formation is performed. The patient has a favourable evolution without over-added neurological deficits. A team of neurologist, neurosurgeon, radiologist, pathologist, radiotherapist, oncologist, anaesthesiologist was involved in this evolution. The team approach to the patient is the key to success, with the patient needing the opinion of each individual doctor.
COMPARATIVE EVALUATION OF MICROLEAKAGE OF NEWER GENERATION OF DENTIN BONDING AGENTS IN CLASS V CAVITY: A DYE PENETRATION STUDY
Authors: Ghone Tejas , Verma Meenakshi , Jain Ashish , Rao Rahul , Sahani Nidhi , Shrivastava Shwetank
Published: April 2022

Aims: This study aims to evaluate the microleakage (ML) of the newer generations bonding agents in Class V Cavity. Materials and Methods: Thirty six mandibular premolars were randomly divided into three groups: Group I (n = 12)â€‘bonded with GlumaBond5, Group II (n = 12) with G-Bond and Group III (n = 12) with Single Bond Universal Adhesive. Class V box cavity was prepared on the buccal surface and restored with composite resin with recommended each groups specific bonding protocol for each adhesive. ML testing were conducted, Rhodamine B and stereomicroscope was used to measure microleakage and data analyzed. Kruskalâ€“Wallis analysis was done to statistically differentiate the ML between the three experimental groups. Intergroup comparison was made using the Mannâ€“Whitney U test and the level of significance was set at p<0.05. Results :Single Bond Universal Adhesive showed maximum resistance to microleakage followed by GlumaBond5 and G- Bond and this difference is statistically significant(p<0.05). Mannâ€“Whitney U test shows statistically significant difference between Group II and Group III. (p<0.05). Conclusions: Within this studys limitation, composite resin bonded with Single Bond Universal Adhesive showed maximumresistance to ML followed by GlumaBond5 and G-Bond.
KNOWLEDGE, ATTITUDE AND PRACTICE ABOUT COVID-19 AND VACCINE ACCEPTANCE AMONG FAMILY PHYSICIAN IN AL-MADINAH
Authors:   Family Medicine Residency Program., Muneer Khushaym Tariq , Al-Johani Abdulaziz ,   Family Medicine Consultant Security Forces Hospital, Saudi Arabia.
Published: April 2022

Background: COVID-19 vaccination is very important to get immunity agents new against SARS-CoV-2. Also, itâ€™s important to know the knowledge and attitude and welling to get vaccination about covid-19 in family physicians cause the are the first line doctor and people get medical information from them so this why we chose this population to assess knowledge and willing to get vaccine. This study aims to assess family physician awareness about covid-19 and its vaccine in al Madinah and to explore the association between knowledge and awareness of covid-19 and acceptance to take its vaccine. The study also assessed the awareness of the covid-19 and the acceptance of covid-19 vaccine. Methodology: A cross-sectional study that was carried out in Al-Madinah. The study was done on family physicians in Al-Madinah. A self-administered questionnaire was used in previous publications in the English language, the questionnaire was done online. By sending the questionnaire by WhatsApp. Data was verified by hand and then was coded, entered, and analyzed using SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp. Official Data was presented using means and standard deviation and frequency number and percent according to the type of variable. The result will significant if p-value <0.05. Results:The study included 152 participants, 57.9% were males and 42.1% were females. 61.2% aged between 25- 30 years old and 24.3% aged between 31- 40 years old. 59.9% of participants strongly agree that SARS-CoV-2 can be transmitted by respiratory droplets. 35.5% strongly agree that Symptoms of COVID-19 can be similar with those of seasonal flu. 52.6% strongly agree that COVID-19 cause serious illness and death. 56.6% of study participants wash their hands before and after contact with the patient/patientâ€™s environment. 30.9% think there is an available specific drug therapy for COVID-19 while 99.3% think is an available vaccine for COVID-19. However, all study participants received vaccine against COVID-19. Only 63.2% think they have sufficient level of knowledge about CIVID-19 and 39.5% intend to take the 3rd dose of vaccine. Conclusion: Health care professionals are expected to be at high risk for COVID-19 because of contact with confirmed and suspected cases at the frontline. Family physicians in Saudi Arabia have moderate level of knowledge, attitude and practice towards COVID-19 vaccine.
SURGICAL MANAGEMENT OF PATHOLOGICAL FRACTURE OF DISTAL FEMORAL DIAPHYSIS WITH METASTASIS - A CASE REPORT
Authors: P. Mahajan Neetin , P. Pande Kartik , Patil Tushar , K. Pramod , a Bagimani
Published: April 2022

Introduction: The femur is the most common bone affected by a metastatic carcinoma and subsequently resulting into a pathological fracture of the bone which directly affects the daily activities of the cancer patient. Pathological fractures caused by metastatic events usually occur in late stage of the disease which are also accompanied by symptoms like severe pain, instability and loss of function. Several factors are considered in the treatment of femoral metastasis, including the location of the lesion, estimated prognosis, nature of the fracture â€“ complete or impending and general condition of the patient. case report: We have a case of a62-year-old male patient who presented to us with the chief complaint of pain in the left thigh since 5 months with no history of significant trauma was found to have distal third femur shaft pathological fracture with a metastatic lesion on MRI who was operated with intra-medullary interlock nail. The patient was started with partial weight bearing walker mobilization on POD3. The patient was able to bear full weight over the operated limb and there was significant reduction in the pain after 1 week post op and the follow up x-ray after 2 months of surgery showed some signs of bridging callus over the lesionand the patient was sent for further evaluation of the suspected unknown primary. Conclusion: As is evident from the above case,patients with a pathological femur fracture operated with an intra-medullary implant were shown to have a significant achievement of pre operative goals of our surgical intervention in the form of reduction of pain, regaining of the range of motion of the affected joints, full weight bearing over the affected limb and a better quality of life with improvement in performance of activities of daily living.
ACUTE DISSEMINATED ENCEPHALOMYELITIS AFTER RABIES VACCINATION: ONE CASE REPORT
Authors:   Department of Infectious Diseases, Mohammed VI University Hospital Cadi Ayad University, Marrakech, Morocco., Ait Driss W. , Ihbibane F. ,   Department of Infectious Diseases, Mohammed VI University Hospital Cadi Ayad University, Marrakech, Morocco., Tassi N. ,   Department of Infectious Diseases, Mohammed VI University Hospital Cadi Ayad University, Marrakech, Morocco.
Published: April 2022

Acute disseminated encephalomyelitis (ADEM) is an inflammatory autoimmune demyelinating disease of the central nervous system (CNS). There is no typical clinical presentation of ADEM. The combination of multiple neurological disorders occurring during infections or vaccination should alarm the clinician. We report a case of ADEM in a 37-year-old patient, occurred 2 months after an anti-rabies vaccine shot. The diagnosis was concluded as we had the anti-rabies vaccination 2 months before the onset of symptoms, clinical symptoms (of encephalomyelitis) and the outcome of nuclear magnetic resonance imaging (bilateral and symmetrical signal abnormalities of both capsules and both Putamens, hyposignal in T1, hypersignal in T2 and FLAIR). IV corticosteroid boluses were administered, followed by oral corticosteroid therapy then gradual dose reduction. Clinical evolution was marked by improving of consciousness, disappearance of the motor deficit and the persistence of irreversible blindness. ADEM is a rare and serious condition of the central nervous system. Early management is the key to avoid complications.
PROSPECTIVE EVALUATION OF PANC 3 SCORE IN PREDICTING SEVERITY OF ACUTE PANCREATITIS
Authors: Rongpi Ranjib , Ahmed Choudhury Imad , Chandra Nath Hemendra , Chandra Baro Atul , Swami Tassa Anadi
Published: April 2022

Background: About 15-20% of cases of acute pancreatitis progress to a severe form, leading to high mortality rates. Thus early prediction of severity is utmost important so as to provide better management and decrease mortality. Objective: To explore the efficiency of PANC 3 SCORE in predicting the severity in patients with acute pancreatitis on admission and its relation to clinical outcome. Methods: Patients with Acute pancreatitis were assessed to sex, age, body mass index (BMI), etiology of pancreatitis, Hematocrit and presence or absence of pleural effusion at the time of admission intensive care need, length of hospital stay, length of stay in intensive care unit and mortality. The PANC 3 score was determined on admission and compared to acute pancreatitis grade of the Revised Atlanta classification. Results: Out of 46 patients diagnosed with acute pancreatitis, 46 patients met the inclusion criteria. The PANC 3 score was positive in 4 cases (8.69%), pancreatitis progressed to a severe form in 7 cases (15.2%) and 3 patients (6.5%) died. Patients with a positive score and severe pancreatitis required intensive care more often, and stayed for a longer period in intensive care units. The PANC 3 score showed sensitivity of 42.85%, specificity of 97.45%, accuracy of 90.17%, positive predictive value of 75% and negative predictive value of 89.13% in prediction of severe acute pancreatitis. Conclusion: The PANC 3 score has high specificity, high accuracy and high predictive value in prediction of severe acute pancreatitis. It has only 3 parameters which can be easily done in any healthcare system. It does not need much expertise to analyze PANC3 at the time of admission which adds the advantage of this score over other scoring systems.
BLOOD PRESSURE RESPONSES BETWEEN TREADMILL AND ERGOMETER CYCLE
Authors:   Assistant Professor, Institute Of Physiology, Madurai Medical College, Madurai., Thendral C. , Vinodha R. ,   Professor And Head Of The Department, Department Of Physiology Thanjavur Medical College, Thanjavur.
Published: April 2022

This study was done to determine the maximal heart rate and blood pressure difference between Treadmill Running and Ergometer cycling. This study was undertaken in research laboratory of physiology department at Thanjavur medical college . 40 persons with the age group of 18-40 Years were taken as subjects. The subjects were recruited from Thanjavur medical college. The subjects were performed 3 discontinuous graded tests until exhaustion. In Bicycle, cycling was done for 2 mins at 60rpm. In Treadmill, initial Warm-up slowly by walking at a speed of 1.5-2 mph for 1min to 2 min. For first 2 weeks subject was asked to run at 4-8 mph for 20 minutes, 3rdweek to 12thweekfor 30 mins at 4-8 mph. Physiological variables blood pressure and maximal heart rate were measured and compared in between Ergometer Cycling and Treadmill Running.
STUDY ON ANTIVIRAL DRUGS RAISENEW HOPES FOR RECOVERY ON SARS-COV-2
Authors:   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Krishna Kommineni Chaitanya , Keethika Oruganti Krishna ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Vakkalagadda Narasimha ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Sai Yogesh Konakandla Venkata ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Kumari Muppa Divya ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Kakani Kumudwati ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Neeraj Krishna Vedantam Sai ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Kumar Vemuri Praveen ,   Department of Biotechnology, KoneruLakshmaiah Education Foundation, Guntur, Andhra Pradesh, India.
Published: April 2022

The goal of this study is to perform a systematic assessment of the literature to determine the effectiveness and safety of molnupiravir and paxlovid oral antiviral drugs in COVID-19 patients.These Drugs has shown consistent efficacy against the SARS-CoV-2 viruss Gamma, Delta, and Mu versions, the firm has yet to release data on the drugs action against Omicron. COVID-19, a worldwide pandemic produced by the SARS-CoV-2 virus, has already wreaked havoc on human life and the global economy. In this study, an attempt is made to comprehend the SARS-CoV-2 life cycle, and prospective druggable targets against SARS-CoV-2 are outlined based on this knowledge. COVID-19, there are more vaccine candidates in the pipeline at the same time than there haveever been for an infectious illness. Theyre all attempting to accomplish the same goal: viral immunity, and some may even be able to block transmission. Whole virus, protein subunit, viral vector, and nucleic acid are the four types of vaccines now being tested in clinical studies.
ACUTE PSYCHOSIS AND RHABDOMYOLYSIS IN THE FACE OF HYPOTHYROIDISM
Authors:   Department of Endocrinology Diabetology and Metabolic Diseases, FIP Laboratory, GFCM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Bouyela N.C Bilihi , M. Camara ,   Department of Endocrinology Diabetology and Metabolic Diseases, FIP Laboratory, GFCM, Cadi Ayyad University, CHU Mohamed VI Marrakech., S. Rafi ,   Department of Endocrinology Diabetology and Metabolic Diseases, FIP Laboratory, GFCM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Mghari G. El ,   Department of Endocrinology Diabetology and Metabolic Diseases, FIP Laboratory, GFCM, Cadi Ayyad University, CHU Mohamed VI Marrakech., Ansari N. El ,   Department of Endocrinology Diabetology and Metabolic Diseases, FIP Laboratory, GFCM, Cadi Ayyad University, CHU Mohamed VI Marrakech.
Published: April 2022

Myxedematous psychosis was first described in 1979 by Pr Asher, it is a rare diagnosis associating an acute psychosis, a rhabdomyolysis whose etiology is hypothyroidism. We report the case of a 32-year-old patient followed for 6 years for schizophrenia, who had not had any treatment for 3 years, and was admitted with an acute psychotic attack consisting of delusions of persecution. The examination revealed an oedematose syndrome, deep hypothyroidism, and high creatine phosphokinase. The treatment was the correction of the hypothyroidism associated with a short psychogenic treatment with a favorable evolution after 1 month of treatment with regression of the psychiatric picture.
INDICADORES DE CALIDAD EN EL SERVICIO DE ANESTESIOLOGIA
Authors: Josue Zarinana Najera Dr. Ian
Published: April 2022

Introduccion:El objetivo central de todo sistema de atencion a la salud es buscar mejorar el estado de salud y satisfacer las necesidades de la poblacion por ello, los elementos y cada una de las variables de todo modelo para intervenir en la salud generan indirectamente influencia en los resultados alcanzados. La definicion de buena calidad de los servicios de salud es dificil y ha sido objeto de muchos acercamientos. Cuando hablamos de Servicios de Salud, constituye un grave error si no pensamos en retroalimentarnos de como apreciaron los pacientes la atencion recibida, y oir de ellos sus recomendaciones Objetivo: Determinar los principales indicadores de calidad en el servicio de anestesiologia del Centro Medico Naval. Resultados:El citado estudio se encuentra en la ultima fase de recoleccion de datos, por el momento se han obtenido 103 individuos, con el objetivo de relacionar la calidad anestesica mediante los indicadores de calidad basados en proceso y estructura ( indice de quirofanos y Dolor postoperatorio), obteniendo como resultados preliminares la evaluacion de la calidad anestesica con un alto numero de cirugias mensuales con una relacion de 12 quirofanos disponibles, el sintoma postoperatorio mas frecuente ha sido escalofrios y dolor en minima proporcion, como dato esencial la percepcion en la comunicacion con el paciente fue con informacion clara sobre los riesgos anestesicos pero confusion al no identificar al anestesiologo responsable en comparacion con el que realiza la visita pre anestesica. Se obtuvo un total de dos indicadores validados. Un indicador, que es el de tiempo de rotacion optimo entre cirugias y el dolor postoperatorio. Se incluyo el porcentaje de la utilizacion de los quirofanos, retrasos prolongados en el cambio de turno y tiempos de espera para cirugia electiva, asi como los sintomas mas frecuentes asociados al dolor postoperatorio. Conclusiones:En el Centro Medico Naval aun no cuenta con la validacion nacional e internacional estandarizada relacionada con este tipo de indicadores, aun falta ser mejorados y con un mayor numero de herramientas para su evaluacion. Por ello, es necesario uniformar conocimientos relacionados con la generacion de dichos indicadores e iniciar la investigacion cientifica para evaluarlos.
FREQUENCY OF HYPOCALCAEMIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors:   Consultant Physician / Medical OfficerHayatabad Medical Complex Peshawar Pakistan., Ali Kifayat , Bakht Zaineb Khush ,   Medical Officer: Shukat Khanum Memorial Cancer Hospital & Research Center Peshawar Pakistan., Ahmad Waqar ,   Medical officer Hatayatabad Medical Complex Peshawar.
Published: April 2022

Background: Chronic kidney disease is a major public health problem worldwide. Kidney failure is becoming increasingly common and is associated with poor health outcomes and high medical expenditures. Objective: To determine the frequency of hypocalcemia among patients with chronic kidney disease. Setting: Department of General Medicine, Hayatabad Medical Complex, Peshawar. Duration of study: Six months 6/5/2019 to 6/11/2019. Study design: Cross sectional study. Materials and Methods: Total 194 patients were included in the study. Detail history, clinical examination and laboratory investigation was preformed for the confirmation of CKD. From all the patients at admission, 3cc of blood was obtained under strict aseptic technique and was immediately sent to hospital laboratory to detect hypocalcaemia and hypocalcaemia was considered positive if the serum corrected calcium level <8.5mg/dL. Results: Stages of CKD was analyzed as 17(9%) patients had CKD stage 1, 29(15%) patients had stage 2, 54(28%) had stage 3, 51(26%) had stage 4, 43(22%) had stage 5 respectively. More over 50(26%) patients had hypocalcemia while 144(74%) patients didnt. Seventy four 74(38%) patients had duration of CKD â‰¤ 6 months while 120(62%) patients had duration of CKD >6 month. Mean duration of CKD was 7 months with standard deviation Â± 3.78. One hundred and forty 140 (72%) patients had weight â‰¤80 Kgs while 54(28%) patients weight >80 Kgs. Mean weight was 76 Kgs with standard deviation Â± 15.29. Conclusion: Frequency of hypocalcemia was found about 26% in patients with chronic kidney disease.
IMPACT OF COVID-19 PANDEMIC ON INTESTINAL PARASITIC INFECTIONS: EXPERIENCE OF PARASITOLOGY AND MYCOLOGY LABORATORY OF AVICENNA MILITARY HOSPITAL IN MARRAKECH
Authors:   Parasitology and Mycology Laboratory, Avicenna Military Hospital Marrakech., Abbassi Saloua ,   Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University., Nachat Soumia ,   Parasitology and Mycology Laboratory, Avicenna Military Hospital Marrakech.,   Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University., Azza Hajiba ,   Parasitology and Mycology Laboratory, Avicenna Military Hospital Marrakech.,   Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University., Mostafa El Mezouari El ,   Parasitology and Mycology Laboratory, Avicenna Military Hospital Marrakech.,   Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University., Moutaj Redouane ,   Parasitology and Mycology Laboratory, Avicenna Military Hospital Marrakech.,   Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University.
Published: April 2022

Intestinal parasitic infections (IPIs) are a worldwide public health threat that remains frequent, especially in countries where hygienic conditions are precarious. The Covid-19 pandemic that the world is experiencing since March 2020 was associated with the establishment of a set of hygienic measures. The aim of this study is to highlight a possible impact of those measures on the prevalence of IPIs by evaluating the results of stool specimens examinations for patients of the Avicenna military hospital in Marrakech for a period extended from 2017 to 2022. The overall prevalence of IPIs was found to be 32%. The prevalence of protozoa infections was much higher than the prevalence of helminthic infections (95% vs. 5%). Amongst the protozoa, blastocystis hominis (BH) was the most common parasite. Our study showed a fall in the overall prevalence of IPIs starting from 2020 and a consequent drop in the prevalence of the most incriminated protozoa in parasitic diarrheas: entamoeba histolytica histolytica and giardia intestinalis. Those findings show the effectiveness of the hygiene measures, implemented during covid-19 pandemic, on the carriage of these parasites. The replacement of Entamoeba histolytica histolytica by blastocystis hominis in terms of pathogenicity could be explained by the reactivation of the carriage of BH due to the imbalance of the intestinal flora caused by the use of alcohol and bleach for sanitization. Therefore the present study highlights the positive impact of hygienic measures, carried out during covid-19 pandemic, on the prevalence of IPIs and leads us to emphasize the need to pursue those measures even outside the pandemic.
Impact of corporate governance and ownership on business performance: A case study of Vietnam
Authors: Xuan Hong Nguyen Thi , Ngoc Dang Hung
Published: April 2022

The study is conducted to investigate the impact of corporate governance and ownership on business performance in listed firms on the Vietnamese Stock Exchange. The study employed the general regression method (GLS) with a sample of 506 listed firms in the period 2008–2020. The study demonstrated the impacts of corporate governance and ownership on firm performance. First, the size of the Board of Directors (BOD), state ownership, and foreign ownership have a positive impact on firm performance. On the contrary, the ratio of independent members in the BOD and the percentage of members of the BOD who are major shareholders have a negative impact on firm performance. An interesting finding is that the BOD with female members, the duality of director and chairman, and the ratio of independent members have a negative impact on the Board of Management. In contrast, firms with no female members in the BOD have a positive relationship with firm performance. The empirical results and recommendations in this study might be good instructions for firms to improve their firm performance.
Elias Canetti’nin “Körleşme” Adlı Eserinde Özyaşamsal Yansımalar
Authors: Çorakli Şahbender , Gürer Burcu
Published: April 2022

Bu makalede, Canetti’nin öz yaşam öyküsünün “Körleşme” adlı romanındaki yansımaları üzerinde durulmuştur. Yazarın bizzat kendisinin kaleme aldığı üç ciltlik öz yaşam öyküsü olan “Kurtarılmış Dil”, “Kulaktaki Meşale” ve “Gözlerin Oyunu” adlı yapıtlar ilgili yansımanın temellendirilmesinde birincil kaynak görevini üstlenmişlerdir. Bu kaynaklar, nitel araştırma türlerinden içerik analizi yöntemiyle taranarak “ Körleşme” adlı eserle birbirine benzediği ya da birbiri ile ilişkisi olduğu düşünülen bölümler tespit edilmiştir. Bu tespitlerden de anlaşılacağı üzere yazarın okuma merakı, bilgiye açlığı, hayata karşı duruşu, tabuları ve yabancılaşması “Körleşme” adlı eserde “Doktor Kien” üzerinden okuyucuyla buluşmuştur. Yazarın hayatı ile eseri arasındaki bu örtüşmeler, Freud’un edebi eser veren bir yazarın ortaya koyduğu eserde ama açık ama örtük bir şekilde yazarın izlerine rastlanacağı görüşünü destekler niteliktedir. Bu sayede, yazıyla ve yazınla erken yaşlarda buluşan Canetti’nin kitaplarla olan imtihanı yakından tecrübe edilerek, “Körleşme”adlı eserindeki yansımalarına açıklık getirilmeye çalışılmış ve gelecekte yapılacak olan benzer çalışmalara katkı sağlamak amaçlanmıştır.
A Single Dose of Local Injection of Adipose Stem Cells Promotes Ectopic
Cartilage Regeneration In Vivo by Modulating Inflammatory Response
and Enhancing Cartilage Extracellular Matrix Synthesis in a Porcine
Model
Authors: Huang Tianyu , Sun Hengyun , Chen Jianguo , Liu Xia , Pan Bo , He Leren , Jiang Haiyue
Published: April 2022

Background:

Uncontrollable inflammatory response following ectopic engineered cartilage
implantation is devastating to the aesthetic and functional outcomes of the recipients. Adipose stem cells
(ASCs) have a good immunomodulatory capacity via a paracrine mechanism. However, works of literature
are scarce regarding ASC modulation in ectopic engineered cartilage regeneration in vivo. This study
aims to explore how ASCs modulate the inflammatory response after engineered cartilage implantation
and affect the implants in a nonchondrogenic milieu in large immunocompetent animals.

Methods:

Porcine engineered elastic cartilages were cultured in vitro for 3 weeks with chondrocyte cell
sheeting technology and then assigned into two groups: ASCs and Control (saline injection). All samples
(n= 6 per group) were autologously implanted into different subcutaneous pockets, and a single dose of
ASCs was injected at three points around the implant. All samples were harvested after 2 weeks in vivo
for analysis.

Results:

In the examination of inflammation, we observed reduced inflammatory cell infiltration and
improved M2 macrophage polarization in the implanted engineered cartilage with ASC injection compared
to the control. There were also enhanced anti-inflammatory cytokines and reduced proinflammatory
cytokines inside and adjacent to the implants, while in serum, there were no significant differences. In the
examination of the cartilage quality, there were significant increases in cartilage extracellular matrix and
chondrogenic factors, and the elastic cartilage phenotype was maintained compared to control.

Conclusion:

This study finds that a single dose of ASCs can promote ectopic cartilage regeneration by
modulating inflammation and enhancing cartilage matrix synthesis in a porcine model.