bluuebunny/crossref_metadata_2025 huggingface dataset:
Lag impacts of the anomalous July soil moisture over Southern China on the August rainfall over the Huang–Huai River Basin
Authors: Dong Xuan , Zhou Yang , Chen Haishan , Zhou Botao , Sun Shanlei
Published: October 2021

The effect of soil moisture (SM) on precipitation is an important issue in the land–atmosphere interaction and shows largely regional differences. In this study, the SM of the ERA-Interim reanalysis and precipitation data of the weather stations were used to investigate their relationship over eastern China during July and August. Moreover, the WRF model was applied to further validate the effect of SM on rainfall. In the observations, a significantly negative relationship was found that, when the soil over southern China is wet (dry) in July, the rainfall decreases (increases) over the Huang–Huai–River basin (hereafter HHR) in August. In the model results, the soil can “memorize” its wet anomaly over southern China from July to August. In August, the wet soil increases the latent heat flux at surface and the air moisture at lower levels of the atmosphere, which is generally unstable due to the summer monsoon. Thus, upward motion is prevailing over southern China in August, and the increased surface air moisture is transported upwards. After that, the condensation of water vapor is enhanced at the middle and upper levels, increasing the release of latent heat in the atmosphere. The heat release forms a cyclonic circulation at the lower levels over eastern China, and induces the transport and convergence of water vapor increased over southern China in August. This further strengthens the upward motion over southern China and the cyclonic circulation at the lower levels. Therefore, positive feedback appears between water vapor transport and atmospheric circulation. Meanwhile, the cyclonic circulation over southern China results in a response of water vapor divergence and a downward motion over HHR. Consequently, the negative anomalies of precipitation occur over HHR in August. When the July soil is dry over southern China, the opposite results can be found through the similar mechanism.
Electronically monitored occlusion therapy in amblyopia with eccentric fixation
Authors: Mehmed Berna , Fronius Maria , Pohl Tabea , Ackermann Hanns , Schramm Charlotte , Spieth Bettina , Hofmann Christian , Kohnen Thomas , Wenner Yaroslava
Published: October 2021

Purpose

Amblyopia with eccentric fixation, especially when not diagnosed early, is a therapeutic challenge, as visual outcome is known to be poorer than in amblyopia with central fixation. Consequently, treatment after late diagnosis is often denied. Electronic monitoring of occlusion provides us the chance to gain first focussed insight into age-dependent dose response and treatment efficiency, as well as the shift of fixation in this rare group of paediatric patients.

Methods

In our prospective pilot study, we examined amblyopes with eccentric fixation during 12 months of occlusion treatment. We evaluated their visual acuity, recorded patching duration using a TheraMon®-microsensor, and determined their fixation with a direct ophthalmoscope. Dose-response relationship and treatment efficiency were calculated.

Results

The study included 12 participants with strabismic and combined amblyopia aged 2.9–12.4 years (mean 6.5). Median prescription of occlusion was 7.7 h/day (range 6.6–9.9) and median daily received occlusion was 5.2 h/day (range 0.7–9.7). At study end, median acuity gain was 0.6 log units (range 0–1.6) and residual interocular visual acuity difference (IOVAD) 0.3 log units (range 0–1.8). There was neither significant acuity gain nor reduction in IOVAD after the 6th month of treatment. Children younger than 4 years showed best response with lowest residual IOVAD at study end. Efficiency calculation showed an acuity gain of approximately one line from 100 h of patching in the first 2 months and half a line after 6 months. There was a significant decline of treatment efficiency with age (p = 0.01). Foveolar fixation was achieved after median 3 months (range 1–6). Three patients (> 6 years) did not gain central fixation.

Conclusion

Eccentric fixation is a challenge to therapy success. Based on electronic monitoring, our study quantified for the first time the reduction of treatment efficiency with increasing age in amblyopes with eccentric fixation. Despite some improvement in patients up to 8 years, older patients showed significantly lower treatment efficiency. In younger patients with good adherence, despite poor initial acuity, central fixation and low residual IOVAD could be attained after median 3 months. Hence, the necessity of early diagnosis and intensive occlusion should be emphasized.
Cardiovascular responses to dynamic and static upper-body exercise in a cold environment in coronary artery disease patients
Authors: Valtonen Rasmus I. P. , Hintsala Heidi H. E. , Kiviniemi Antti , Kenttä Tuomas , Crandall Craig , van Marken Lichtenbelt Wouter , Perkiömäki Juha , Hautala Arto , Jaakkola Jouni J. K. , Ikäheimo Tiina M.
Published: October 2021

Purpose

Upper-body exercise performed in a cold environment may increase cardiovascular strain, which could be detrimental to patients with coronary artery disease (CAD). This study compared cardiovascular responses of CAD patients during graded upper-body dynamic and static exercise in cold and neutral environments.

Methods

20 patients with stable CAD performed 30 min of progressive dynamic (light, moderate, and heavy rating of perceived exertion) and static (10, 15, 20, 25 and 30% of maximal voluntary contraction) upper body exercise in cold (− 15 °C) and neutral (+ 22 °C) environments. Heart rate (HR), blood pressure (BP) and electrocardiographic (ECG) responses were recorded and rate pressure product (RPP) calculated.

Results

Dynamic-graded upper-body exercise in the cold increased HR by 2.3–4.8% (p = 0.002–0.040), MAP by 3.9–5.9% (p = 0.038–0.454) and RPP by 18.1–24.4% (p = 0.002–0.020) when compared to the neutral environment. Static graded upper-body exercise in the cold resulted in higher MAP (6.3–9.1%; p = 0.000–0.014), lower HR (4.1–7.2%; p = 0.009–0.033), but unaltered RPP compared to a neutral environment. Heavy dynamic exercise resulted in ST depression that was not related to temperature. Otherwise, ECG was largely unaltered during exercise in either thermal condition.

Conclusions

Dynamic- and static-graded upper-body exercise in the cold involves higher cardiovascular strain compared with a neutral environment among patients with stable CAD. However, no marked changes in electric cardiac function were observed. The results support the use of upper-body exercise in the cold in patients with stable CAD.

Trial registration

Clinical trial registration NCT02855905 August 2016.
Kidney length normative values in children aged 0–19 years — a multicenter study
Authors: Obrycki Łukasz , Sarnecki Jędrzej , Lichosik Marianna , Sopińska Małgorzata , Placzyńska Małgorzata , Stańczyk Małgorzata , Mirecka Julia , Wasilewska Agnieszka , Michalski Maciej , Lewandowska Weronika , Dereziński Tadeusz , Pac Michał , Szwarc Natalia , Annusewicz Karol , Rekuta Viktoriia , Ažukaitis Karolis , Čekuolis Andrius , Wierzbicka-Rucińska Aldona , Jankauskiene Augustina , Kalicki Bolesław , Jobs Katarzyna , Tkaczyk Marcin , Feber Janusz , Litwin Mieczysław
Published: October 2021

Background

Currently used pediatric kidney length normative values are based on small single-center studies, do not include kidney function assessment, and focus mostly on newborns and infants. We aimed to develop ultrasound-based kidney length normative values derived from a large group of European Caucasian children with normal kidney function.

Methods

Out of 1,782 children aged 0–19 years, 1,758 individuals with no present or past kidney disease and normal estimated glomerular filtration rate had sonographic assessment of kidney length. The results were correlated with anthropometric parameters and estimated glomerular filtration rate. Kidney length was correlated with age, height, body surface area, and body mass index. Height-related kidney length curves and table were generated using the LMS method. Multivariate regression analysis with collinearity checks was used to evaluate kidney length predictors.

Results

There was no significant difference in kidney size in relation to height between boys and girls. We found significant (p < 0.001), but clinically unimportant (Cohen’s D effect size = 0.04 and 0.06) differences between prone vs. supine position (mean paired difference = 0.64 mm, 95% CI = 0.49–0.77) and left vs. right kidneys (mean paired difference = 1.03 mm, 95% CI = 0.83–1.21), respectively. For kidney length prediction, the highest coefficient correlation was observed with height (adjusted R2 = 0.87, p < 0.0001).

Conclusions

We present height-related LMS-percentile curves and tables of kidney length which may serve as normative values for kidney length in children from birth to 19 years of age. The most significant predictor of kidney length was statural height.

Graphic Abstract
A Splitting Result for Real Submanifolds of a Kähler Manifold
Authors: Biliotti Leonardo
Published: October 2021

Let $$(Z,\omega )$$

(
Z
,
ω
)

be a connected Kähler manifold with an holomorphic action of the complex reductive Lie group $$U^\mathbb {C}$$

U
C

, where U is a compact connected Lie group acting in a hamiltonian fashion. Let G be a closed compatible Lie group of $$U^\mathbb {C}$$

U
C

and let M be a G-invariant connected submanifold of Z. Let $$x\in M$$

x
∈
M

. If G is a real form of $$U^\mathbb {C}$$

U
C

, we investigate conditions such that $$G\cdot x$$

G
·
x

compact implies $$U^\mathbb {C}\cdot x$$

U
C

·
x

is compact as well. The vice-versa is also investigated. We also characterize G-invariant real submanifolds such that the norm-square of the gradient map is constant. As an application, we prove a splitting result for real connected submanifolds of $$(Z,\omega )$$

(
Z
,
ω
)

generalizing a result proved in Gori and Podestà (Ann Global Anal Geom 26: 315–318, 2004), see also Bedulli and Gori (Results Math 47: 194–198, 2005), Biliotti (Bull Belg Math Soc Simon Stevin 16: 107–116 2009).
Modifications and hybrids of 1,2,3,4-tetrahydropyridinium salts and their antiprotozoal potencies
Authors: Seebacher Werner , Mohsin Noor-ul-Amin , Dolensky Johanna , Hochegger Patrick , Kaiser Marcel , Mäser Pascal , Saf Robert , Schuster Daniela , Temml Veronika , Weis Robert
Published: October 2021

The antiprotozoal activity of 1-benzyltetrahydropyridin-4-yliden iminium salts is reported. This paper describes the preparation of a series of analogs from dihydropyridines or dihydrothiopyrans as educts. The new compounds were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis (sleeping sickness). Several structure–activity relationships were detected. Both the substituents in ring positions 1 and 4 of the tetrahydropyridinium moiety had a strong impact on the antiprotozoal activities as well as on the cytotoxicity of compounds against L-6 cells (rat skeletal myoblasts). All new compounds were characterized using FT-IR spectroscopy, HRMS, and NMR spectroscopy.

Graphic abstract
Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
Authors: Krus David , Kahn Fredrik , Nilson Bo , Sunnerhagen Torgny , Rasmussen Magnus
Published: October 2021

Non-β-hemolytic streptococci (NBHS) cause infective endocarditis (IE) and a short blood culture time to positivity (TTP) is associated with risk of IE in bacteremia with other pathogens. In this retrospective population-based cohort study, we investigate if TTP is associated to IE or mortality. Of 263 episodes with NBHS bacteremia, 28 represented IE and the median TTP did not differ significantly between episodes with IE (15 h) and non-IE (15 h) (p=0.51). TTP was similar among those who survived and those who died within 30 days. However, TTP significantly differed when comparing the different streptococcal groups (p<0.001).
Estimation of the cost-effective threshold of a quality-adjusted life year in China based on the value of statistical life
Authors: Cai Dan , Shi Si , Jiang Shan , Si Lei , Wu Jing , Jiang Yawen
Published: October 2021

Cost-effective threshold (CET) is essential for health technology assessment and decision-making based on health economic evaluations. Recently, it has been argued that the commonly used once and three times of gross domestic product (GDP) per capita CETs of a quality-adjusted life year (QALY) are not necessarily empirically supported in all countries. Therefore, we aimed to estimate the CET of a QALY as times of GDP per capita in China, of which the reimbursement coverage decisions are increasingly engaging economic evaluations. Estimates on the value of statistical life (VSL) in China were identified from several studies in the literature and converted to times of GDP per capita, the weighted average of which was used for subsequent calculation. By pooling data on population mortality, health utility, and age distribution, we estimated the value of a statistical QALY (VSQ) from VSL using an established mathematical process, which represented the theoretical upper bound of CET. The corresponding point estimate and theoretical lower bound were obtained using their numerical relationships with the upper bound. Scenarios analyses were also conducted. The estimated CET, its upper bound, and its lower bound were 1.45, 2.90, and 1.16 times of GDP per capita in China, respectively. In different scenarios, the estimated CET varied but was greater than once GDP per capita in most cases. As such, the CET of a QALY in China is close to 1.5 times of GDP per capita, which should be benchmarked for future ICER-based coverage decisions.
Investigation of a Capnometry Guided Respiratory Intervention in the Treatment of Posttraumatic Stress Disorder
Authors: Ostacher Michael J. , Fischer Eileen , Bowen Ellie R. , Lyu Jihun , Robbins Denishia J. , Suppes Trisha
Published: October 2021

Evidence‐based treatments for posttraumatic stress disorder (PTSD), including psychotherapies and medications, have high dropout and nonresponse rates, suggesting that more acceptable and effective treatments for PTSD are needed. Capnometry Guided Respiratory Intervention (CGRI) is a digital therapeutic effective in panic disorder that measures and displays end-tidal carbon dioxide (EtCO2) and respiratory rate (RR) in real-time within a structured breathing protocol and may have benefit in PTSD by moderating breathing and EtCO2 levels. We conducted a single-arm study of a CGRI system, Freespira®, to treat symptoms of PTSD. Participants with PTSD (n = 55) were treated for four weeks with twice-daily, 17-min at-home CGRI sessions using a sensor and tablet with pre-loaded software. PTSD and associated symptoms were assessed at baseline, end-of treatment, 2-months and 6-months post-treatment. Primary efficacy outcome was 50% of participants having ≥ 6-point decrease in Clinician Administered PTSD Scale (CAPS-5) score at 2-month follow up. Tolerability, usability, safety, adherence and patient satisfaction were assessed. CGRI was well tolerated, with 88% [95% CI 74–96%] having ≥ 6-point decrease in CAPS-5 scores at 2-months post-treatment follow up. Mean CAPS-5 scores decreased from 49.5 [s.d. = 9.2] at baseline to 27.1 [s.d. = 17.8] at 2-months post-treatment follow up. Respiratory rate decreased and EtCO2 levels increased. Associated mental and physical health symptoms also improved. This CGRI intervention was safe, acceptable, and well-tolerated in improving symptoms in this study in PTSD. Further study against an appropriate comparator is warranted.

Trial registration Clinicaltrials.gov NCT#03039231.
Decolonizing Deliberative Democracy: Perspectives from Below
Authors: Banerjee Subhabrata Bobby
Published: October 2021

In this paper I provide a decolonial critique of received knowledge about deliberative democracy. Legacies of colonialism have generally been overlooked in theories of democracy. These omissions challenge several key assumptions of deliberative democracy. I argue that deliberative democracy does not travel well outside Western sites and its key assumptions begin to unravel in the ‘developing’ regions of the world. The context for a decolonial critique of deliberative democracy is the ongoing violent conflicts over resource extraction in the former colonies of Africa, Asia and Latin America. I argue that deliberative democracy cannot take into account the needs of marginalized stakeholders who are defending their lands and livelihoods. The paper contributes to the literature by (1) offering a critique of hegemonic models of democracy that cannot address issues of inequality and colonial difference and (2) offering possibilities to imagine counterhegemonic alternatives for a democratization of democracy from below.
Enabling the Voices of Marginalized Groups of People in Theoretical Business Ethics Research
Authors: Alm Kristian , Guttormsen David S. A.
Published: October 2021

The paper addresses an understudied but highly relevant group of people within corporate organizations and society in general—the marginalized—as well as their narration, and criticism, of personal lived experiences of marginalization in business. They are conventionally perceived to lack traditional forms of power such as public influence, formal authority, education, money, and political positions; however, they still possess the resources to impact their situations, their circumstances, and the structures that determine their situations. Business ethics researchers seldom consider marginalized people’s voices and experiences as resources to understand their lives, as demonstrated through a review of 7500 articles published in the Journal of Business Ethics and Business Ethics Quarterly (2000–2019). Only 78 studies included aspects of marginalized groups. 69 of those studies discussed the topic of marginalized groups of people, but without integrating their explicit voices into the text. Only 9 of the 78 articles featured marginalized people’s explicit voices about their marginalization experiences incorporated into the text as a source for exploration. None of the identified studies discussed the potential for theorizing based on such voices. This paper contributes to business ethics theory by developing four theoretical possibilities vis-à-vis the critical voices of marginalized people’s experiences in business: (a) marginalized theory on critical agency and freedom of speech; (b) the gatekeeping role of academia; (c) primary sources; and (d) a participative perspective. Discussing the theoretical potential of quoting the above voices can enrich business ethics research in terms of the theoretical understanding of marginalized groups in business.
Subclinical leaflet thrombosis after transcatheter aortic valve implantation: no association with left ventricular reverse remodeling at 1-year follow-up
Authors: Kuneman Jurrien H. , Singh Gurpreet K. , Hansson Nicolaj C. , Fusini Laura , Poulsen Steen H. , Fortuni Federico , Vollema E. Mara , Pedersen Anders L. D. , Annoni Andrea D. , Nørgaard Bjarne L. , Pontone Gianluca , Ajmone Marsan Nina , Delgado Victoria , Bax Jeroen J. , Knuuti Juhani
Published: October 2021

Hypo-attenuated leaflet thickening (HALT) of transcatheter aortic valves is detected on multidetector computed tomography (MDCT) and reflects leaflet thrombosis. Whether HALT affects left ventricular (LV) reverse remodeling, a favorable effect of LV afterload reduction after transcatheter aortic valve implantation (TAVI) is unknown. The aim of this study was to examine the association of HALT after TAVI with LV reverse remodeling. In this multicenter case–control study, patients with HALT on MDCT were identified, and patients without HALT were propensity matched for valve type and size, LV ejection fraction (LVEF), sex, age and time of scan. LV dimensions and function were assessed by transthoracic echocardiography before and 12 months after TAVI. Clinical outcomes (stroke or transient ischemic attack, heart failure hospitalization, new-onset atrial fibrillation, all-cause mortality) were recorded. 106 patients (age 81 ± 7 years, 55% male) with MDCT performed 37 days [IQR 32–52] after TAVI were analyzed (53 patients with HALT and 53 matched controls). Before TAVI, all echocardiographic parameters were similar between the groups. At 12 months follow-up, patients with and without HALT showed a significant reduction in LV end-diastolic volume, LV end-systolic volume and LV mass index (from 125 ± 37 to 105 ± 46 g/m2, p = 0.001 and from 127 ± 35 to 101 ± 27 g/m2, p < 0.001, respectively, p for interaction = 0.48). Moreover, LVEF improved significantly in both groups. In addition, clinical outcomes were not statistically different. Improvement in LVEF and LV reverse remodeling at 12 months after TAVI were not limited by HALT.
Sodium-glucose cotransporter 2 inhibitors and heart failure: the best timing for the right patient
Authors: Severino Paolo , D’Amato Andrea , Prosperi Silvia , Costi Bettina , Angotti Danilo , Birtolo Lucia Ilaria , Chimenti Cristina , Lavalle Carlo , Maestrini Viviana , Mancone Massimo , Fedele Francesco
Published: October 2021

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs, have shown many beneficial effects on the cardiovascular system, in particular against heart failure (HF). HF is a complex and multifaceted disease that requires a comprehensive approach. It should not be considered as a simplistic cardiac disease, but a systemic disease that leads to multisystemic organ failure and death. Exploiting their pleiotropic effects, SGLT2i are a very valid tool for HF treatment. Beyond the indication to reduce HF hospitalization and death risk, in patients with diabetes mellitus at high cardiovascular risk or with established cardiovascular event, SGLT2i administration reported beneficial effects regarding the wide spectrum of HF manifestations and stages, independently by diabetes mellitus presence. Recent evidence focuses on HF rehospitalization, cardiac and all-cause death reduction, as well as symptoms and quality of life improvement, in patients with chronic HF or with a recent HF decompensation episode. Given the recent finding about the SGLT2i usefulness in HF patients, further studies are needed to define the best administration timing to maximize the SGLT2i-derived beneficial effects.
Device design and optimization of CNTFETs for high-frequency applications
Authors: Peng Boli , Annamalai Manojkumar , Mothes Sven , Schröter Michael
Published: October 2021

Carbon nanotube (CNT) field-effect transistors (FETs) have recently reached high-frequency (HF) performance similar to that of silicon RF-CMOS at the same gate length despite a tube density and current per tube that are far from the physical limits and suboptimal device architecture. This work reports on an investigation of the optimal device design for practical HF applications in terms of cut-off frequencies, power gain, and linearity. Different fundamental designs in the gate contact arrangement are considered based on a 3D device simulation of both CNTs and contacts. First, unit cells with a single CNT and minimal contact sizes are compared. The resulting simulation data are then extended toward a structure with two gate fingers and realistic contact sizes. Corresponding parasitic capacitances, as well as series and contact resistances, have been included for obtaining realistic characteristics and figures of merit that can be used for comparison with corresponding silicon RF MOSFETs. Finally, a sensitivity analysis of the device architecture with the highest performance is performed in order to find the optimal device design space.
The Readiness for Return to Work Scale; Does it Help in Evaluation of Return to Work?
Authors: Aasdahl Lene , Fimland Marius Steiro , Røe Cecilie
Published: October 2021

Purpose The Readiness for Return to Work (RRTW) scale is used to evaluate workers’ readiness to resume work after sick leave. Previous research has questioned the RRTW scale’s constructs and stages. The aim of this study was to assess the unidimensionality of the RRTW scale and its six subscales by evaluating its fit to the Rasch model, and furthermore to assess if Rasch-based scaling would improve its predictive value, compared with the conventional use of the scale. Methods A prospective cohort study with 12 months of follow-up. Individuals (n = 397) sick-listed due to musculoskeletal, unspecified, or common mental health disorders undergoing rehabilitation were included: 191 were full-time sick-listed (not working), and 206 were part-time sick-listed (working). A Rasch analysis was applied to evaluate the measurement properties of the RRTW scale in the working and not working participants at baseline. Linear and logistic regressions were used to assess how well Rasch-based scaling predicted future work participation during the 12 months of follow-up. Results The RRTW subscales had too few items to represent underlying dimensions properly, and the items fitted poorly within the subscales. A constructed variable based on the items that fit together for not working individuals poorly predicted future work participation. The individuals’ scores across stages were disordered, indicating a lack of ordered stages. Conclusions This study reveals poor measurement properties of the Norwegian version of the RRTW scale in individuals with musculoskeletal and common mental disorders, with neither the subscales nor the stages closely associated with return to work.
What is a plant nutrient? Changing definitions to advance science and innovation in plant nutrition
Authors: Brown Patrick H. , Zhao Fang-Jie , Dobermann Achim
Published: October 2021

Current definitions of essential or beneficial elements for plant growth rely on narrowly defined criteria that do not fully represent a new vision for plant nutrition and compromise fertilizer regulation and practice. A new definition of what is a plant nutrient that is founded in science and relevant in practice has the potential to revitalize innovation and discovery. A proposed new definition might read: A mineral plant nutrient is an element which is essential or beneficial for plant growth and development or for the quality attributes of the plant or harvested product, of a given plant species, grown in its natural or cultivated environment. A plant nutrient may be considered essential if the life cycle of a diversity of plant species cannot be completed in the absence of the element. A plant nutrient may be considered beneficial if it does not meet the criteria of essentiality, but can be shown to benefit plant growth and development or the quality attributes of a plant or its harvested product. It includes elements currently identified as essential, elements for which a clear plant metabolic function has been identified, as well as elements that have demonstrated clear benefits to plant productivity, crop quality, resource use efficiency, stress tolerance or pest and disease resistance. We propose an open scientific debate to refine and implement this updated definition of plant nutrients. Other outcomes of this debate could be a more precise definition of the experimental evidence required to classify an element as a plant nutrient, and an independent scientific body to regularly review the list of essential and beneficial nutrients. The debate could also attempt to refine the definition of plant nutrients to better align with nutrients deemed essential for animal and human nutrition, thus following a more holistic ’one nutrition‘ concept.
A novel survey of raptor collections in Europe and their potential to provide samples for pan-European contaminant monitoring
Authors: Ramello Gloria , Duke Guy , Dekker Rene W. R. J. , van der Mije Steven , Movalli Paola
Published: October 2021

This paper provides a novel survey of current collections of frozen raptor carcasses and tissue samples in natural history museums (NHMs), environmental specimen banks (ESBs) and other research collections (ORCs e.g. at universities and research institutes) across Europe and assesses the extent to which collections might support pan-European raptor biomonitoring through the provision of samples for contaminant analyses. The paper is based on questionnaire responses received in late 2018 and early 2019 from 116 institutions. Issues covered include the number of raptor carcasses and diversity of raptor species arriving annually at collections, the number of carcasses stored in freezers, the extent to which collections retain frozen tissue samples, what records are kept of carcasses and tissue samples, constraints to expanding collections of frozen carcasses and tissues and the extent to which collections currently engage in ecotoxicological research and monitoring. Our findings show that collections in Europe receive well over 5000 raptor carcasses per annum, and that NHMs are the key recipients of raptor carcasses for most countries. Collections in Europe probably hold well over 10,000 raptor carcasses in their freezers, offering a substantial resource of frozen raptor carcasses and tissues from recent years. Moreover, these carcasses include good specimen numbers for species that have been prioritized for pan-European contaminant monitoring. Collections are becoming digitized aiding access to samples. However, freezer capacity is a key constraint to retention of carcasses, and contaminant biomonitoring is novel for most NHMs. Our findings on the repository and availability of frozen raptor carcasses and tissues held by collections in Europe can enable greater use of these specimens for pan-European contaminant monitoring in support of better chemicals management. We highlight opportunities to further optimize raptor collections for pan-European contaminant monitoring.
Transplanting Hybrid Potato Seedlings at Increased Densities Enhances Tuber Yield and Shifts Tuber-Size Distributions
Authors: van Dijk Luuk C. M. , de Vries Michiel E. , Lommen Willemien J. M. , Struik Paul C.
Published: October 2021

To contribute to the development of a novel cropping system for potato grown from greenhouse-derived seedlings from hybrid true potato seeds, planting density trials were carried out under normal Dutch agronomic conditions. For two consecutive years, 5-week-old seedlings of two experimental genotypes were transplanted into farmers’ potato production fields at two contrasting locations: a flat-bed system on sandy soil and a traditional ridge system on clay soil. Planting densities were 6.25, 12.5, 25, 50, 100 and 200 plants/m2 in the flat-bed system, and 3.125, 4.688, 6.25, 12.5, 25 and 50 plants/m2 in the ridge system. In general, increasing planting density of hybrid seedlings per area decreased tuber fresh weight per plant and reduced the number of tubers per plant. On a per hectare basis, an increased planting density resulted in increased total tuber yield and number of tubers up to very high densities, but finally both parameters levelled off. Highest total tuber yields harvested were 107 and 45 Mg/ha for the flat-bed and ridge system, respectively. On flat-beds, the optimal planting density for total yield was 50 plants/m2. On ridges, planting density interacted with year and genotype, resulting in an optimum planting density of 25 plants/m2 to reach the maximum total yield. Obtained yields in the commercial size classes Baby Baker (20 < size class ≤ 35 mm) and Seed Tubers (28 < size class ≤ 50 mm) were in general very high on the flat-beds, with a maximum Seed Tuber yield of 64 Mg/ha at 50 plants/m2. The current study showed that transplanted hybrid seedlings are feasible alternatives for seed-tuber-grown systems for certain potato outlets.
Sexual health-related care needs among young adult cancer patients and survivors: a systematic literature review
Authors: Lehmann Vicky , Laan Ellen T. M. , den Oudsten Brenda L.
Published: October 2021

Purpose

Young adult cancer patients and survivors have age-specific care needs, but care needs related to sexual health are poorly understood. A systematic literature review was conducted to examine sexual health-related care needs among patients/survivors diagnosed with cancer during young adulthood (age: 18–39 years). The prevalence and types needs were assessed along with associated patient factors.

Methods

Four major databases were screened to identify relevant studies, which were also assessed for risk of bias; all following PRISMA guidelines.

Results

Identified studies (N = 35) often assessed sexual health-related care needs by whether participants experienced a generic need for support from providers. The prevalence of such needs ranged between 8 and 61.7% and was higher in female survivors and those with more health impairments. The type of diagnosis could also play a role in these varying prevalence rates, but was not systematically tested in included studies. Types of sexual health-related care needs were clustered into practical/emotional support needs (e.g., coping with physical side effects), information needs (e.g., more details), and communication needs (e.g., providers should initiate conversations, validate concerns, be empathetic/open). Needs should be addressed in-person and/or online.

Conclusions

The extent of needs related to sexual health varies among young adult patients and survivors, but types of needs center around improving provision of support and information by providers.

Implications for Cancer Survivors

Sexual health should routinely be addressed alongside other potential effects of cancer treatment to allow for constructive conversations between patients and providers. Referrals to (online) resources or specialists should be tailored to individual preferences.
Fixed point theorems in preordered sets
Authors: Górnicki Jarosław
Published: October 2021

Ran and Reurings (Proc Am Math Soc 132(5):1435–1443, 2003) extended the Banach contraction principle to the setting of partially ordered metric spaces and recently Proinov (J Fixed Point Theory Appl 22:21, 2020) extended and unified many earlier fixed point theorems. In this paper we will present analogous results for the significantly wider class of mappings on preordered metric spaces. We give non-trivial examples of Kannan-type mappings.
Ambarzumian-type Problems for Discrete Schrödinger Operators
Authors: Hatinoğlu Burak , Eakins Jerik , Frendreiss William , Lamb Lucille , Manage Sithija , Puente Alejandra
Published: October 2021

We discuss the problem of unique determination of the finite free discrete Schrödinger operator from its spectrum, also known as the Ambarzumian problem, with various boundary conditions, namely any real constant boundary condition at zero and Floquet boundary conditions of any angle. Then we prove the following Ambarzumian-type mixed inverse spectral problem: diagonal entries except the first and second ones and a set of two consecutive eigenvalues uniquely determine the finite free discrete Schrödinger operator.
Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma
Authors: Su Li , Zhang Jicheng , Zhang Xinglong , Zheng Lei , Zhu Zhifa
Published: October 2021

Gallbladder cancer (GBC), the most common malignancy in the biliary tract, is highly lethal malignant due to seldomly specific symptoms in the early stage of GBC. This study aimed to identify exosome-derived miRNAs mediated competing endogenous RNAs (ceRNA) participant in GBC tumorigenesis. A total of 159 differentially expressed miRNAs (DEMs) was identified as exosome-derived miRNAs, contains 34 upregulated exo-DEMs and 125 downregulated exo-DEMs based on the expression profiles in GBC clinical samples downloaded from the Gene Expression Omnibus database with the R package. Among them, 2 up-regulated exo-DEMs, hsa-miR-125a-3p and hsa-miR-4647, and 5 down-regulated exo-DEMs, including hsa-miR-29c-5p, hsa-miR-145a-5p, hsa-miR-192-5p, hsa-miR-194-5p, and hsa-miR-338-3p, were associated with the survival of GBC patients. Results of the gene set enrichment analysis showed that the cell cycle-related pathways were activated in GBC tumor tissues, mainly including cell cycle, M phase, and cell cycle checkpoints. Furthermore, the dysregulated ceRNA network was constructed based on the lncRNA-miRNA-mRNA interactions using miRDB, TargetScan, miRTarBase, miRcode, and starBase v2.0., consisting of 27 lncRNAs, 6 prognostic exo-DEMs, and 176 mRNAs. Together with prognostic exo-DEMs, the STEAP3-AS1/hsa-miR-192-5p/MAD2L1 axis was identified, suggesting lncRNA STEAP3-AS1, might as a sponge of exosome-derived hsa-miR-192-5p, modulates cell cycle progression via affecting MAD2L1 expression in GBC tumorigenesis. In addition, the biological functions of genes in the ceRNA network were also annotated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Our study promotes exploration of the molecular mechanisms associated with tumorigenesis and provide potential targets for GBC diagnosis and treatment.
It’s all about control: Sense of control mediates the relationship between physical activity and mental health during the COVID-19 pandemic in Germany
Authors: Precht Lena-Marie , Margraf Jürgen , Stirnberg Jan , Brailovskaia Julia
Published: October 2021

COVID-19-related burden has a significant impact on mental health and has led to an increase of depression, anxiety, and stress symptoms. Physical activity has been suggested to mitigate the negative effects of the pandemic and to foster mental health. The present study aimed to investigate, whether sense of control might mediate the supposed beneficial effects of physical activity on positive (PMH) and negative mental health (NMH) in unpredictable extraordinary situations. Data were assessed in a sample of 568 students (Mage = 19.90, SDage = 4.52) from Germany via an online survey in fall 2020. Mediation analyses revealed that sense of control mediated the relation between physical activity and PMH as well as depression, anxiety, and stress symptoms, respectively. The findings indicate that physical activity may be a promising strategy for fostering sense of control and thus mental health. Due to its practical implications and practicability, engagement in physical activity could be an effective way to reduce the NMH consequences of the current COVID-19 situation, and therefore should be addressed in actions for long-term prevention and intervention.
Identification hub genes of consensus molecular subtype correlation with immune infiltration and predict prognosis in gastric cancer
Authors: Yu Xin , Yu Bin , Fang Weidan , Xiong Jianping , Ma Mei
Published: October 2021

Gastric cancer (GC) has a great fatality rate, meanwhile, there is still a lack of available biomarkers for prognosis. The goal of the research was to discover key and novel potential biomarkers for GC. We screened for the expression of significantly altered genes based on survival rates from two consensus molecular subtypes (CMS) of GC. Subsequently, functional enrichment analysis showed these genes involved in many cancers. And we picked 6 hub genes that could both secreted in the tumor microenvironment and expression enhanced in immune cells. Then, Kaplan Meier survival and expression detected in the tumor pathological stage were utilized to clarify the prognostic of these 6 hub genes. The results indicated that OGN, CHRDL2, C2orf40, THBS4, CHRDL1, and ANGPTL1, respectively, were significantly associated with poor OS in GC patients. And their expression increased with cancer advanced. Moreover, immune infiltration analysis displayed that those hub genes expression positively with M2 macrophage, CD8+ T Cell, most immune inhibitors, and majority immunostimulators. In summary, our results suggested that OGN, CHRDL2, C2orf40, THBS4, CHRDL1, and ANGPTL1 were all potential biomarkers for GC prognosis and might also be potential therapeutic targets for GC.
Micropore structure and water driving characteristics of tight sandstone reservoirs in Ordos Basin
Authors: Zhou Shuxun , Zhou Yan , Shi Jian , Zhu Yujie , Xiao Wulin , Zhang Rui
Published: October 2021

In order to explore the influence of the micropore structure of the tight sandstone reservoir in the water driving characteristics, the studies on the Chang 6 tight sandstone reservoir of the middle-western part of Ordos Basin are carried out by various experiments such as cast-thin section analysis, scanning electron microscopy, high-pressure mercury injection and micro-water driving. The result shows that the permeability contribution curves of samples shift to the left as the sample permeability decreases, indicating that the greater the permeability, the greater the proportion of large pores. The permeability is mostly dominated by pores with the radius larger than R50–R60. There are big differences in the water driving type, oil-driven efficiency and residual oil distribution characteristics between reservoirs of different types. The type II reservoir is the major target of subsequent exploration and development, where water driving types consist of mesh and finger, leaving the residual oil mainly locked by water or isolated as oil drops. The size and distribution feature of pores are the key factors dominating the oil-driven efficiency.
The changing microRNA landscape by color and cloudiness: a cautionary tale for nipple aspirate fluid biomarker analysis
Authors: Patuleia Susana I. S. , van der Wall Elsken , van Gils Carla H. , Bakker Marije F. , Jager Agnes , Voorhorst-Ogink Marleen M. , van Diest Paul J. , Moelans Cathy B.
Published: October 2021

Purpose

Investigation of nipple aspirate fluid (NAF)-based microRNAs (miRNAs) as a potential screening tool for women at increased risk of developing breast cancer is the scope of our research. While aiming to identify discriminating NAF-miRNAs between women with different mammographic densities, we were confronted with an unexpected confounder: NAF sample appearance. Here we report and alert for the impact of NAF color and cloudiness on miRNA assessment.

Methods

Seven classes of NAF colors coupled with cloudiness appearance were established. Using 173 NAF samples from 154 healthy women (19 samples were bilaterally collected), the expression of 14 target and 2 candidate endogenous control (EC) miRNAs was investigated using Taqman Advanced miRNA assays to identify significant differential expression patterns between color-cloudiness classes. Inter- and intra-individual variation of miRNA expression was analyzed using the coefficient of variation (CV).

Results

We found that between the seven NAF classes, fold change miRNA expression differences ranged between 2.4 and 19.6 depending on the interrogated miRNA. Clear NAF samples exhibited higher miRNA expression levels compared to cloudy NAF samples with fold change differences ranging between 1.1 and 6.2. Inter-individual and intra-individual miRNA expression was fairly stable (CV < 15 %), but nevertheless impacted by NAF sample appearance. Within NAF classes, inter-individual variation was largest for green samples (CV 6-15 %) and smallest for bloody samples (CV 2-6 %).

Conclusions

Our data indicate that NAF color and cloudiness influence miRNA expression and should, therefore, be systematically registered using an objective color classification system. Given that sample appearance is an inherent feature of NAF, these variables should be statistically controlled for in multivariate data analyses. This cautionary note and recommendations could be of value beyond the field of NAF-miRNAs, given that variability in sample color and cloudiness is likewise observed in liquid biopsies such as urine, cerebrospinal fluid and sputum, and could thereby influence the levels of miRNAs and other biomarkers.
Fetal Congenital Mesoblastic Nephroma: Case Report
Authors: Patil Prajakta Aloorkar , Vemarapu Gayatri
Published: October 2021

Congenital mesoblastic nephroma (CMN) is a rare renal tumor, but the commonest tumor of early infancy. It can be detected prenatally as a renal mass and is associated with prematurity, polyhydramnios, and neonatal hypertension. We report a case of congenital mesoblastic nephroma which presented as a large unilateral solid renal mass detected at 33 weeks of gestation associated with oligohydramnios and small for gestational age (SGA) fetus. Ultrasound features were a large hypoechoic mass arising from the upper pole of the Left kidney measuring 52 ⅹ 43 ⅹ 32 mm. Inside the mass there were incomplete septae and a few cystic areas, likely hemorrhagic areas, with minimal peripheral vascularity. The mass was surrounded by a hyperechoic capsule. The left adrenal gland could be imaged separately. The baby was delivered by a lower segment cesarean section (LSCS) at 38 weeks of gestation. After birth, the baby presented with a mass per abdomen with no other symptoms and no hypertension. CT scan and ultrasound guided biopsy confirmed the finding of the cellular variant of congenital mesoblastic nephroma. Left radical nephrectomy with adrenal gland conservation was performed on day 8 of life. Postoperative adjuvant chemotherapy was administered. On follow-up, the baby is asymptomatic with no relapse or metastasis. Fetal CMN and Wilms tumor have overlapping ultrasound features and are difficult to differentiate on prenatal ultrasound. Prenatal detection of fetal renal tumors and timely neonatal management improve perinatal outcome.
Effect of corporate social responsibility on consumer retention for FMCG industries: a deep learning analysis of professional students of Odisha
Authors: Das Santanu Kumar
Published: October 2021

Corporate social responsibility (CSR) represents a form of international private business self-regulation that contributes to the social aims of a charitable, activist, or philanthropic nature through helping ethically based practices. The benefits from CSR like generating better public image, enhance in community support, enhance in market share, enhance in the satisfaction of the consumer, enhance in the exports, offering better quality services and products, and enhance in the productivity is not considered as the perception level consumers. This paper analyzes the effect of CSR activities on the fast moving consumer goods (FMCG) industries on the basis of the retention of the consumers of FMCG products. Initially, a questionnaire is prepared that consists of five categories. Each category is composed of more than ten questions. The information related to the questionnaire is obtained in the view of the professional students from Odisha. The customers are requested to fill the exact information as much as possible. Next, a higher-order statistical analysis is considered for realizing the behaviour of the categories. Additionally, the usage of deep learning called Optimized RNN (O-RNN) is used for predicting the customer retention in maintaining the CSR on FMCG industries. The improvement in the traditional RNN is done by optimizing the hidden neurons by the improved form of Sea Lion Optimization Algorithm (slno) called Modified slno (M-slno) with the intention of minimizing the error among the actual and the predicted outcome, hence it is called as O-RNN. The retention of the customers regarding the effect of CSR activities on FMCG companies and the benefits from CSR is investigated using the O-RNN prediction analysis against several traditional deep learning models as well as different statistical measures.