bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Contact Tracing Technologies for Infection Prevention and Control Purposes in Nosocomial Settings: A Systematic Literature Review
Authors: Stokes Katy , Piaggio Davide , De Micco Francesco , Zarro Marianna , De Benedictis Anna , Tambone Vittoradolfo , Moon Madison , Maccaro Alessia , Pecchia Leandro
Published: June 2024

Background: Pandemic management and preparedness are more needed than ever before and there is widespread governmental interest in learning from the COVID-19 pandemic in order to ensure the availability of evidence-based Infection Prevention and Control measures. Contact tracing is integral to Infection Prevention and Control, facilitating breaks in the chain of transmission in a targeted way, identifying individuals who have come into contact with an infected person, and providing them with instruction/advice relating to testing, medical advice and/or self-isolation. Aim: This study aims to improve our understanding of the use of contact tracing technologies in healthcare settings. This research seeks to contribute to the field of Infection Prevention and Control by investigating how these technologies can mitigate the spread of nosocomial infections. Ultimately, this study aims to improve the quality and safety of healthcare delivery. Methods: A systematic literature review was conducted, and journal articles investigating the use of contact tracing technologies in healthcare settings were retrieved from databases held on the OvidSP platform between March and September 2022, with no date for a lower limit. Results: In total, 277 studies were retrieved and screened, and 14 studies were finally included in the systematic literature review. Most studies investigated proximity sensing technologies, reporting promising results. However, studies were limited by small sample sizes and confounding factors, revealing contact tracing technologies remain at a nascent stage. Investment in research and development of new testing technologies is necessary to strengthen national and international contact tracing capabilities. Conclusion: This review aims to contribute to those who intend to create robust surveillance systems and implement infectious disease reporting protocols.
Physical Activity and Associated Factors among Brazilian Adult Inmates: A Cross-Sectional Study
Authors: Baccon Wanessa Cristina , Laranjeira Carlos , Marques Priscila Garcia , Höring Carla Franciele , Gallo Adriana Martins , Araujo Juliane Pagliari , Marques Francielle Renata Danielli Martins , Carreira Lígia , Salci Maria Aparecida
Published: June 2024

Previous studies on health in prison facilities have determined that imprisonment has adverse effects on both physical and emotional well-being. Therefore, the introduction of public health measures is encouraged. This study aimed to (a) evaluate the levels of physical activity and the health condition of a sample of Brazilian prisoners and (b) determine the predictors of low physical activity. An observational and cross-sectional study was developed following the STROBE checklist. Data collection took place between June and November 2019 in a maximum-security Brazilian prison institution. This study’s final sample included 220 people selected through convenience sampling, of which 115 (53.2%) were aged 18 to 29 years, followed by 79 (36.6%) aged 30 to 44 years and 22 (10.2%) aged 45 to 59 years old. Overall, 64.3% of participants failed to meet the World Health Organization (WHO) recommendation for physical activity [at least 150–300 min of moderate-intensity or 75 min of vigorous-intensity aerobic physical activity per week]. The majority reported unhealthy food consumption (116; 53.7%). Regarding body mass index (BMI), 50.2% of individuals were classified as eutrophic, 38.1% were overweight and 11.6% were obese. Older age (AOR: 0.95; CI95%: 0.92–0.99; p = 0.01) and sitting time (AOR: 0.74; CI95%: 0.65–0.85; p < 0.01) were associated with low adherence to physical activity. Our results highlight the importance of practicing physical activity within the prison context and the need for institutional programs that promote regular physical activity.
Dry–Wet Changes in a Typical Agriculture and Pasture Ecotone in China between 1540 and 2019
Authors: Wang Xiaodong , Song Yujia , An Yu , Liu Xiaohui , Li Xiaoqiang
Published: June 2024

Exploring periodic dry–wet changes is an important topic in climate change research due to its impact on drought and flood disasters. The purpose of this research was to determine the occurrence law of dry–wet changes in China on a scale of several hundred years, using the example of transitional zones. In this study, we analyzed typical areas of the ecotone between agricultural land and pasture along the Great Wall of China. The ring width index of Carya cathayensis was fitted with the March–August Palmer drought severity index (PDSI38). The PDSI38 was divided into different periods using the stepwise function fitting method. The results indicated that there were two dry periods and one wet period in the region from 1543 to 2019. In each dry and wet period, there were also different temporal periods, including long (decades), intermediate (ten years), and short periods (several years). Drought represents a significant threat to agricultural production in China. In the first dry period (1543–1756), four periods with low PDSI38 values (1633–1635, PDSI38 = −1.71; 1636–1939, PDSI38 = −3.35; 1640–1642, PDSI38 = −4.68; and 1643–1645, PDSI38 = −2.92) occurred, during which severe droughts (PDSI38 < −4) lasted for 13 years. The dry–wet change showed the characteristics of a 12-year or multiple 12-year cycle. The results can be used to prepare to effectively address extreme drought scenarios worldwide in the future.
QTL Analysis of β-Glucan Content and Other Grain Traits in a Recombinant Population of Spring Barley
Authors: Gianinetti Alberto , Ghizzoni Roberta , Desiderio Francesca , Morcia Caterina , Terzi Valeria , Baronchelli Marina
Published: June 2024

Barley with high grain β-glucan content is valuable for functional foods. The identification of loci for high β-glucan content is, thus, of great importance for barley breeding. Segregation mapping for the content in β-glucan and other barley grain components (starch, protein, lipid, ash, phosphorous, calcium, sodium) was performed using the progeny of the cross between Glacier AC38, a mutant with high amylose, and CDC Fibar, a high β-glucan waxy cultivar. The offspring of this cross showed transgressive segregation for β-glucan content. Linkage analysis based on single-nucleotide polymorphism (SNP) molecular markers was used for the genotyping of the parents and recombinant inbred lines (RILs). Two Quantitative Trait Loci (QTL) for β-glucan content and several QTL for other grain components were found. The former ones, located on chromosomes 1H and 7H, explained 27.9% and 27.4% of the phenotypic variance, respectively. Glacier AC38 provided the allele for high β-glucan content at the QTL on chromosome 1H, whereas CDC Fibar contributed the allele at the QTL on chromosome 7H. Their recombination resulted in a novel haplotype with higher β-glucan content, up to 18.4%. Candidate genes are proposed for these two QTL: HvCslF9, involved in β-glucan biosynthesis, for the QTL on chromosome 1H; Horvu_PLANET_7H01G069300, a gene encoding an ATP-Binding Cassette (ABC) transporter, for the QTL on chromosome 7H.
Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants
Authors: Dymanowska-Dyjak Izabela , Frankowska Karolina , Abramiuk Monika , Polak Grzegorz
Published: June 2024

Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility is caused by a wide range of abnormalities affecting the female reproductive tract, from oocyte quality impairment to disturbances in the eutopic endometrium or mechanical abnormalities resulting from disease progression. Since supportive antioxidant therapies, in addition to surgical treatment or assisted reproductive techniques (ARTs), have overall been proven to be effective tools in endometriosis management, the objective of our review was to analyze the role of antioxidant substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, in endometriosis-related infertility. Most of these substances have been proven to alleviate the systemic oxidant predominance, which has been expressed through decreased oxidative stress (OS) markers and enhanced antioxidative defense. In addition, we demonstrated that the predominant effect of the aforementioned substances is the inhibition of the development of endometriotic lesions as well as the suppression of pro-inflammatory molecules. Although we can undoubtedly conclude that antioxidants are beneficial in fertility support, further studies explaining the detailed pathways of their action are needed.
Molecular Markers for Marker-Assisted Breeding for Biotic and Abiotic Stress in Melon (Cucumis melo L.): A Review
Authors: Shahwar Durre , Khan Zeba , Park Younghoon
Published: June 2024

Melon (Cucumis melo L.) is a globally grown crop renowned for its juice and flavor. Despite growth in production, the melon industry faces several challenges owing to a wide range of biotic and abiotic stresses throughout the growth and development of melon. The aim of the review article is to consolidate current knowledge on the genetic mechanism of both biotic and abiotic stress in melon, facilitating the development of robust, disease-resistant melon varieties. A comprehensive literature review was performed, focusing on recent genetic and molecular advancements related to biotic and abiotic stress responses in melons. The review emphasizes the identification and analysis of quantitative trait loci (QTLs), functional genes, and molecular markers in two sections. The initial section provides a comprehensive summary of the QTLs and major and minor functional genes, and the establishment of molecular markers associated with biotic (viral, bacterial, and fungal pathogens, and nematodes) and abiotic stress (cold/chilling, drought, salt, and toxic compounds). The latter section briefly outlines the molecular markers employed to facilitate marker-assisted backcrossing (MABC) and identify cultivars resistant to biotic and abiotic stressors, emphasizing their relevance in strategic marker-assisted melon breeding. These insights could guide the incorporation of specific traits, culminating in developing novel varieties, equipped to withstand diseases and environmental stresses by targeted breeding, that meet both consumer preferences and the needs of melon breeders.
Sphingolipids: Less Enigmatic but Still Many Questions about the Role(s) of Ceramide in the Synthesis/Function of the Ganglioside Class of Glycosphingolipids
Authors: Schengrund Cara-Lynne
Published: June 2024

While much has been learned about sphingolipids, originally named for their sphinx-like enigmatic properties, there are still many unanswered questions about the possible effect(s) of the composition of ceramide on the synthesis and/or behavior of a glycosphingolipid (GSL). Over time, studies of their ceramide component, the sphingoid base containing the lipid moiety of GSLs, were frequently distinct from those performed to ascertain the roles of the carbohydrate moieties. Due to the number of classes of GSLs that can be derived from ceramide, this review focuses on the possible role(s) of ceramide in the synthesis/function of just one GSL class, derived from glucosylceramide (Glc-Cer), namely sialylated ganglio derivatives, initially characterized and named gangliosides (GGs) due to their presence in ganglion cells. While much is known about their synthesis and function, much is still being learned. For example, it is only within the last 15–20 years or so that the mechanism by which the fatty acyl component of ceramide affected its transport to different sites in the Golgi, where it is used for the synthesis of Glu- or galactosyl-Cer (Gal-Cer) and more complex GSLs, was defined. Still to be fully addressed are questions such as (1) whether ceramide composition affects the transport of partially glycosylated GSLs to sites where their carbohydrate chain can be elongated or affects the activity of glycosyl transferases catalyzing that elongation; (2) what controls the differences seen in the ceramide composition of GGs that have identical carbohydrate compositions but vary in that of their ceramide and vice versa; (3) how alterations in ceramide composition affect the function of membrane GGs; and (4) how this knowledge might be applied to the development of therapies for treating diseases that correlate with abnormal expression of GGs. The availability of an updatable data bank of complete structures for individual classes of GSLs found in normal tissues as well as those associated with disease would facilitate research in this area.
Beyond Psychotropic: Potential Repurposing of Fluoxetine toward Cancer Therapy
Authors: Kadasah Sultan F. , Alqahtani Abdulaziz M. S. , Alkhammash Abdullah , Radwan Mohamed O.
Published: June 2024

Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed a beneficial approach for a quick and cost-effective drug discovery process by skipping preclinical, Phase 1 trials and pharmacokinetic studies. Several psychotropic drugs, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), were studied for their potential application in different diseases, especially in cancer therapy. Fluoxetine (FLX) is one of the most prescribed psychotropic agents from the SSRIs class for the treatment of several neuropsychiatric disorders with a favorable safety profile. FLX exhibited different oncolytic effects via mechanisms distinct from its main serotonergic activity. Taking advantage of its ability to rapidly penetrate the blood–brain barrier, FLX could be particularly useful in brain tumors. This was proved by different in vitro and in vivo experiments using FLX as a monotherapy or combination with temozolomide (TMZ) or radiotherapy. In this review of the literature, we summarize the potential pleiotropic oncolytic roles of FLX against different cancers, highlighting the multifaceted activities of FLX and its ability to interrupt cancer proliferation via several molecular mechanisms and even surmount multidrug resistance (MDR). We elaborated on the successful synergistic combinations such as FXR/temozolomide and FXR/raloxifene for the treatment of glioblastoma and breast cancer, respectively. We showcased beneficial pharmaceutical trials to load FLX onto carriers to enhance its safety and efficacy on cancer cells. This is the first review article extensively summarizing all previous FLX repurposing studies for the management of cancer.
Genetic Modifiers of Stroke in Patients with Sickle Cell Disease—A Scoping Review
Authors: Oni Morohuntodun O. , Brito Miguel , Rotman Chloe , Archer Natasha M.
Published: June 2024

Sickle cell disease (SCD) clinically manifests itself with a myriad of complications. Stroke, both ischemic and hemorrhagic, as well as silent white matter changes, occurs at a relatively high prevalence. Understanding why and in whom stroke is most likely to occur is critical to the effective prevention and treatment of individuals with SCD. Genetic studies, including genome- and exome-wide association studies (GWAS and EWAS), have found several key modifiers associated with increased stroke/stroke risk in SCD via mechanisms including Hemoglobin F (HbF) modulation, inflammation, cellular adhesion, endothelial disruption, and hemolysis. We present a review on the modifiers that have most clearly demonstrated an association to date. More studies are needed to validate other potential polymorphisms and identify new ones. Incorporating gene-focused screenings in clinical care could provide avenues for more targeted, more effective, and less toxic prevention of stroke in this population. The data from this review will be used to inform the initial GWAS performed by the International Hemoglobinopathy Research Network (INHERENT) consortium.
Platelet-Rich Plasma (PRP) and Injectable Platelet-Rich Fibrin (i-PRF) in the Non-Surgical Treatment of Periodontitis—A Systematic Review
Authors: Niemczyk Wojciech , Janik Katarzyna , Żurek Jacek , Skaba Dariusz , Wiench Rafał
Published: June 2024

The gold standard in the non-surgical treatment of periodontitis is scaling and root planing (SRP). In recent years, the use of autogenous platelet concentrates has spread over many specialties in dentistry and, thus, has also been gaining popularity in periodontal treatment. Its two main fractions are platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), which, since 2014, can also be used via injection as injectable platelet-rich fibrin (i-PRF). The authors conducted a comprehensive systematic review in accordance with the PRISMA 2020 guidelines. It involved searching PubMed, Embase, Scopus, and Google Scholar databases using the phrases (“Root Planing” OR “Subgingival Curettage” OR “Periodontal Debridement”) AND (“Platelet-Rich Plasma”). Based on the authors’ inclusion and exclusion criteria, 12 results were included in the review, out of 1170 total results. The objective of this review was to ascertain the impact of utilizing PRP and i-PRF in SRP. The results revealed that both the incorporation of PRP and i-PRF were found to be significantly associated with are duction in gingival pocket depth and again in clinical attachment level; however, i-PRF demonstrated superiority in improving clinical parameters. Furthermore, i-PRF demonstrated notable bactericidal efficacy against Porphyromonas gingivalis. On the other hand, PRP proved inferior to an Nd:YAG laser in clinical parameter improvement; however, it demonstrated significant efficiency as well. This literature review led the authors to the conclusion that autologous platelet concentrates might be competent agents for improving the therapeutic outcomes of SRP.
Decreasing Intracellular Entropy by Increasing Mitochondrial Efficiency and Reducing ROS Formation—The Effect on the Ageing Process and Age-Related Damage
Authors: Poljšak Borut , Milisav Irina
Published: June 2024

A hypothesis is presented to explain how the ageing process might be influenced by optimizing mitochondrial efficiency to reduce intracellular entropy. Research-based quantifications of entropy are scarce. Non-equilibrium metabolic reactions and compartmentalization were found to contribute most to lowering entropy in the cells. Like the cells, mitochondria are thermodynamically open systems exchanging matter and energy with their surroundings—the rest of the cell. Based on the calculations from cancer cells, glycolysis was reported to produce less entropy than mitochondrial oxidative phosphorylation. However, these estimations depended on the CO2 concentration so that at slightly increased CO2, it was oxidative phosphorylation that produced less entropy. Also, the thermodynamic efficiency of mitochondrial respiratory complexes varies depending on the respiratory state and oxidant/antioxidant balance. Therefore, in spite of long-standing theoretical and practical efforts, more measurements, also in isolated mitochondria, with intact and suboptimal respiration, are needed to resolve the issue. Entropy increases in ageing while mitochondrial efficiency of energy conversion, quality control, and turnover mechanisms deteriorate. Optimally functioning mitochondria are necessary to meet energy demands for cellular defence and repair processes to attenuate ageing. The intuitive approach of simply supplying more metabolic fuels (more nutrients) often has the opposite effect, namely a decrease in energy production in the case of nutrient overload. Excessive nutrient intake and obesity accelerate ageing, while calorie restriction without malnutrition can prolong life. Balanced nutrient intake adapted to needs/activity-based high ATP requirement increases mitochondrial respiratory efficiency and leads to multiple alterations in gene expression and metabolic adaptations. Therefore, rather than overfeeding, it is necessary to fine-tune energy production by optimizing mitochondrial function and reducing oxidative stress; the evidence is discussed in this paper.
Preferential Co-Expression and Colocalization of rDNA-Contacting Genes with LincRNAs Suggest Their Involvement in Shaping Inter-Chromosomal Interactions with Nucleoli
Authors: Tchurikov Nickolai A. , Alembekov Ildar R. , Klushevskaya Elena S. , Kretova Antonina N. , Lukicheva Viktoriya N. , Chechetkin Vladimir R. , Kravatskaya Galina I. , Kravatsky Yuri V.
Published: June 2024

Different developmental genes shape frequent dynamic inter-chromosomal contacts with rDNA units in human and Drosophila cells. In the course of differentiation, changes in these contacts occur, coupled with changes in the expression of hundreds of rDNA-contacting genes. The data suggest a possible role of nucleoli in the global regulation of gene expression. However, the mechanism behind the specificity of these inter-chromosomal contacts, which are rebuilt in every cell cycle, is not yet known. Here, we describe the strong association of rDNA-contacting genes with numerous long intergenic non-coding RNAs (lincRNAs) in HEK293T cells and in initial and differentiated K562 cells. We observed that up to 600 different lincRNAs were preferentially co-expressed with multiple overlapping sets of rDNA-contacting developmental genes, and there was a strong correlation between the genomic positions of rDNA-contacting genes and lincRNA mappings. These two findings suggest that lincRNAs might guide the corresponding developmental genes toward rDNA clusters. We conclude that the inter-chromosomal interactions of rDNA-contacting genes with nucleoli might be guided by lincRNAs, which might physically link particular genomic regions with rDNA clusters.
Structural Insights into the Mechanisms Underlying Polyaminopathies
Authors: Wu Bing , Liu Sen
Published: June 2024

Polyamines are ubiquitous in almost all biological entities and involved in various crucial physiological processes. They are also closely associated with the onset and progression of many diseases. Polyaminopathies are a group of rare genetic disorders caused by alterations in the function of proteins within the polyamine metabolism network. Although the identified polyaminopathies are all rare diseases at present, they are genetically heritable, rendering high risks not only to the carriers but also to their descendants. Meanwhile, more polyaminopathic patients might be discovered with the increasing accessibility of gene sequencing. This review aims to provide a comprehensive overview of the structural variations of mutated proteins in current polyaminopathies, in addition to their causative genes, types of mutations, clinical symptoms, and therapeutic approaches. We focus on analyzing how alterations in protein structure lead to protein dysfunction, thereby facilitating the onset of diseases. We hope this review will offer valuable insights and references for the future clinical diagnosis and precision treatment of polyaminopathies.
Synergistic Effect of Co-Administered SARS-CoV-2 Vaccines Improves Immune Responses in BALB/c Mice: A Preliminary Study
Authors: Jonas Nshimirimana , Kimani Josephine , Kimotho James , Munyao Matthew Mutinda , Nzou Samson Muuo
Published: June 2024

Various vaccine platforms have been approved for broad use to prevent the transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, these vaccines exhibit distinct differences in immunogenicity and efficacy, which decline after vaccination and are further exacerbated by the emergence of virus variants and mutants. This study reports the immunization outcomes against the SARS-CoV-2 virus by assessing the immune responses and safety of different SARS-CoV-2 vaccines co-administered in BALB/c mice. Vaccine combinations comprising mRNA/adenovirus26-vector, mRNA/inactivated, adenovirus26-vector/inactivated, and mRNA/adenovirus26-vector/inactivated vaccines were prepared in optimized doses, and their activities upon immunization evaluated in comparison with individual mRNA, adenovirus26-vectored, and inactivated vaccines. Fourteen- and 28-days post-immunization, we measured spike-specific IgG response using Enzyme-Linked Immunosorbent Assay (ELISA), cytokine expression profiles through Quantitative real-time polymerase chain reaction (RT-PCR), and evaluated safety through histopathological examination. The mRNA/Vector/Inactivated group exhibited slightly higher anti-spike IgG levels, albeit not statistically significant (p > 0.132). Importantly, this regimen induced elevated IL-6 and IFN-γ mRNA expression levels (p < 0.0001) compared to immunization with individual vaccines. In summary, this study demonstrated that co-administering the mRNA/adenovirus26 vector/inactivated SARS-CoV-2 vaccines improved spike-specific IgG response, triggered significantly enhanced IL-6 and IFN-γ mRNA expression levels, and proved safe in mice.
The Non-Invasive Detection of Pulmonary Exacerbations in Disorders of Mucociliary Clearance with Breath Analysis: A Systematic Review
Authors: Nessen Emma , Toussaint Belle , Israëls Joël , Brinkman Paul , Maitland-van der Zee Anke-Hilse , Haarman Eric
Published: June 2024

Background: Disorders of mucociliary clearance, such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and bronchiectasis of unknown origin, are characterised by periods with increased respiratory symptoms, referred to as pulmonary exacerbations. These exacerbations are hard to predict and associated with lung function decline and the loss of quality of life. To optimise treatment and preserve lung function, there is a need for non-invasive and reliable methods of detection. Breath analysis might be such a method. Methods: We systematically reviewed the existing literature on breath analysis to detect pulmonary exacerbations in mucociliary clearance disorders. Extracted data included the study design, technique of measurement, definition of an exacerbation, identified compounds and diagnostic accuracy. Results: Out of 244 identified articles, 18 were included in the review. All studies included patients with CF and two also with PCD. Age and the definition of exacerbation differed between the studies. There were five that measured volatile organic compounds (VOCs) in exhaled breath using gas chromatography with mass spectrometry, two using an electronic nose and eleven measured organic compounds in exhaled breath condensate. Most studies showed a significant correlation between pulmonary exacerbations and one or multiple compounds, mainly hydrocarbons and cytokines, but the validation of these results in other studies was lacking. Conclusions: The detection of pulmonary exacerbations by the analysis of compounds in exhaled breath seems possible but is not near clinical application due to major differences in results, study design and the definition of an exacerbation. There is a need for larger studies, with a longitudinal design, international accepted definition of an exacerbation and validation of the results in independent cohorts.
IL-1 Inhibitors in the Treatment of Familial Mediterranean Fever: Treatment Indications and Clinical Features in a Large Real-World Cohort
Authors: Yalcin-Mutlu Melek , Icacan Ozan Cemal , Yildirim Fatih , Temiz Selahattin Alp , Fagni Filippo , Schett Georg , Tascilar Koray , Minopoulou Ioanna , Burul Gokhan , Bes Cemal
Published: June 2024

Background: The accruing evidence about the efficacy of anti-IL-1 agents in Familial Mediterranean Fever (FMF) patients led to their widespread off-label use. Therefore, identifying precise indications and clinical characteristics of IL-1i-warranting patients are important. This study investigated the clinical characteristics and treatment indications of patients with FMF requiring interleukin 1 inhibition therapy (IL-1i). Methods: Hospital records of FMF patients attending a tertiary care center at the Department of Rheumatology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital were retrospectively analyzed. Data on symptoms and disease manifestations, age of symptom onset, time to diagnosis, MEFV variants, type of treatment, and their indications were collected. Results: Between June 2020 and March 2023, 312 FMF patients were identified. The mean age at the onset of symptoms was 14.0, and the mean time to diagnosis was 11.9 years. In total, 87.1% of patients were receiving colchicine monotherapy, while the remaining 11.8% warranted IL-1i. Clinical symptoms and flare manifestations did not show a significant difference between the two groups. However, patients receiving IL-1i started having symptoms at younger age (11.5 vs. 14.5, p = 0.042) and time to diagnosis was longer (18.2 vs. 11.0, p < 0.01). M694V homozygosity was more common in patients receiving IL-1i. Indications for patients receiving IL-1i were colchicine resistance (8.0%), secondary amyloidosis (5.1%), and colchicine intolerance (2.2%). Conclusions: This study shows that a subset of FMF patients, particularly those with a more severe phenotype with an earlier disease onset and M694V homozygosity, require IL-1i treatment despite the overall good efficacy and tolerability of colchicine, primarily due to colchicine resistance, intolerance, or complications such as amyloidosis.
Estimated Pulse Wave Velocity and All-Cause and Cardiovascular Mortality in the General Population
Authors: Prelević Vladimir , Blagus Luka , Bošnjak Vito , Radunović Danilo , Marinović Glavić Mihaela , Premužić Vedran , Kos Jelena , Pećin Ivan , Željković Vrkić Tajana , Domislović Marija , Jelaković Ana , Domislović Viktor , Capak Krunoslav , Bubaš Marija , Kriksić Valentina , Jelaković Bojan
Published: June 2024

Background: Carotid-femoral pulse wave velocity (cfPWV), acknowledged as a reliable proxy of arterial stiffness, is an independent predictor of cardiovascular (CV) events. Carotid-femoral PWV is considered the gold standard for the estimation of arterial stiffness. cfPWV is a demanding, time consuming and expensive method, and an estimated PWV (ePWV) has been suggested as an alternative method when cfPWV is not available. Our aim was to analyze the predictive role of ePWV for CV and all-cause mortality in the general population. Methods: In a stratified random sample of 1086 subjects from the general Croatian adult population (EH-UH study) (men 42.4%, average age 53 ± 16), subjects were followed for 17 years. ePWV was calculated using the following formula: ePWV = 9.587 − 0.402 × age + 4.560 × 10−3 × age2 − 2.621 × 10−5 × age2 × MBP + 3.176 × 10−3 × age × MBP − 1.832 × 10−2 × MBP. MBP= (DBP) + 0.4(SBP − DBP). Results: At the end of the follow-up period, there were 228 deaths (CV, stroke, cancer, dementia and degenerative diseases, COLD, and others 43.4%, 10.5%, 28.5%, 5.2%, 3.1%, 9.3%, respectively). In the third ePWV tercile, we observed more deaths due to CV disease than to cancer (20.5% vs. 51.04%). In a Cox regression analysis, for each increase in ePWV of 1 m/s, there was a 14% increase risk for CV death. In the subgroup of subjects with higher CV risk, we found ePWV to be a significant predictor of CV deaths (ePWV (m/s) CI 1.108; p < 0.029; HR 3.03, 95% CI 1.118–8.211). Conclusions: In subjects with high CV risk, ePWV was a significant and independent predictor of CV mortality.
Mechanical Performance of Recycled 3D Printed Sustainable Polymer-Based Composites: A Literature Review
Authors: Kyriakidis Ioannis Filippos , Kladovasilakis Nikolaos , Pechlivani Eleftheria Maria , Tsongas Konstantinos
Published: June 2024

The development of efficient waste valorization strategies has emerged as an important field in the overall efforts for alignment with the environmental goals that have been set by the European Union (EU) Green Deal regarding the development of sustainable circular economy models. Additive manufacturing has emerged as a sustainable method for secondary life product development with the main advantages of it being a form of net-zero waste production and having the ability to successfully transport complex design to actual products finding applications in the industry for rapid prototyping or for tailored products. The insertion of eco-friendly sustainable materials in these processes can lead to significant reduction in material footprints and lower energy demands for the manufacturing process, helping achieve Sustainable Development Goal 12 (SDG12) set by the EU for responsible production and consumption. The aim of this comprehensive review is to state the existing progress regarding the incorporation of sustainable polymeric composite materials in additive manufacturing (AM) processes and identify possible gaps for further research. In this context, a comprehensive presentation of the reacquired materials coming from urban and industrial waste valorization processes and that are used to produce sustainable composites is made. Then, an assessment of the printability and the mechanical response of the constructed composites is made, by taking into consideration some key thermal, rheological and mechanical properties (e.g., viscosity, melting and degradation temperature, tensile and impact strength). Finally, existing life cycle analysis results are presented regarding overall energy demands and environmental footprint during the waste-to-feedstock and the manufacturing processes. A lack of scientific research was observed, regarding the manifestation of novel evaluation techniques such as dynamic mechanical analysis and impact testing. Assessing the dynamic response is vital for evaluating whether these types of composites are adequate for upscaling and use in real life applications.
Emotional Competency in Education: Special Issue on Emotional Intelligence and Creativity
Authors: Celume Macarena-Paz , Zenasni Franck
Published: June 2024

According to Salovey and Mayer (1990), having high EI allows individuals to think clearly, supports intuition and insight, and ultimately enhances creative thinking [...]
Effects of Oil Concentration in Flood Cooling on Cutting Force, Tool Wear and Surface Roughness in GTD-111 Nickel-Based Superalloy Slot Milling
Authors: Kónya Gábor , Kovács Zsolt F.
Published: June 2024

Cooling–lubricating processes have a big impact on cutting force, tool wear, and the quality of the machined surface, especially for hard-to-machine superalloys, so the choice of the right cooling–lubricating method is of great importance. Nickel-based superalloys are among the most difficult materials to machine due to their high hot strength, work hardening, and extremely low thermal conductivity. Previous research has shown that flood cooling results in the least tool wear and cutting force among different cooling–lubricating methods. Thus, the effects of the flood oil concentration (3%; 6%; 9%; 12%; and 15%) on the above-mentioned factors were investigated during the slot milling of the GTD-111 nickel-based superalloy. The cutting force was measured during machining with a Kistler three-component dynamometer, and then after cutting the tool wear and the surface roughness on the bottom surface of the milled slots were measured with a confocal microscope and tactile roughness tester. The results show that at a 12% oil concentration, the tool load and tool wear are the lowest; even at an oil concentration of 15%, a slight increase is observed in both factors. Essentially, a higher oil concentration reduces friction between the tool and the workpiece contact surface, resulting in reduced tool wear and cutting force. Furthermore, due to less friction, the heat generation in the cutting zone is also reduced, resulting in a lower heat load on the tool, which increases tool life. It is interesting to note that the 6% oil concentration had the highest cutting force and tool wear, and strong vibration was heard during machining, which is also reflected in the force signal. The change in oil concentration did not effect the surface roughness.
Modeling and Optimization of the Air-Supported Membrane Coal Shed Structure in Ports
Authors: Dong Mingwang , Zhang Huimin , Tang Daogui , Guo Xiaohai , Gu Yong , Qiao Lei , Guerrero Josep M.
Published: June 2024

The air-supported membrane coal shed is widely used in bulk cargo terminals. It not only effectively protects goods from adverse weather conditions but also helps reduce coal dust and harmful gas emissions, promoting the green and sustainable development of ports. However, in practical engineering, the design parameters of the coal shed are often based on experience, making it difficult to accurately assess the quality of the structural design. The flexibility of the membrane material also makes the structure susceptible to deformation or tearing. This paper mainly focuses on modeling and solving the optimization design issues of air-supported membrane coal shed structures. According to the evaluation criteria for the form of air-supported membrane coal sheds, a multi-objective structural optimization model is established to minimize the maximum stress on the membrane surface, ensure uniform stress distribution, maximize structural stiffness, and minimize costs. The study utilizes a combined optimization approach using ANSYS 19.0 and MATLAB 2016a, incorporating an improved NSGA-II algorithm program developed in MATLAB into ANSYS for structural form analysis and load calculation. The research results indicate that the optimal solution reduces the maximum stress on the loaded membrane surface by 5.36%, shortens the maximum displacement by 30.3%, and saves on economic costs by 9.85%. Compared to traditional empirical design methods, the joint use of MATLAB and ANSYS for optimization design can provide more superior solutions, helping ports to achieve environmental protection and economic efficiency goals.
Experimental Study on Local Scour at the Monopile Foundation of an Offshore Wind Turbine under the Combined Action of Wave–Current–Vibration
Authors: Shi Li , Cheng Yongzhou , Zheng Yuwei , Xia Bo , Huang Xiaoyun
Published: June 2024

Monopile foundations are the most widely used offshore wind turbine foundations. The experiments were conducted to investigate the influencing factors of local scour around the monopile under the action of wave–current–vibration. The study analyzed the characteristics of local scour, including the maximum scour depth, the development of scour hole shape, and the shape of the scour hole profile. The dimensionless influencing factors (vibration intensity, Froude number, Keulegan–Carpenter number, and combined wave–current parameter) are subsequently analyzed. An empirical formula is developed to predict the local scour depth of a monopile under the combined influence of wave–current–vibration. The formula provides a theoretical underpinning for engineering design.
Exploring the Resilience of Islamic Stock in Indonesia and Asian Markets
Authors: Nofrianto Nofrianto , Nugraha Deni Pandu , Ahmed Amanj Mohamed , Muttaqin Zaenal , Fekete-Farkas Maria , Hágen István
Published: June 2024

This study aims to investigate the relationship between returns and risk of Islamic stock under stable economic conditions, crises, and pandemics within the scope of Indonesian and Asian Islamic capital markets. How do economic conditions affect the risks and returns of investors in the Indonesian and Asian Islamic capital markets? Verification of the veracity of the Islamic capital market serves as a more resilient option for alternative investments. This study uses Granger causality to determine exogenous and endogenous variables when building the model. The model that is formed is then analyzed using regression with dummy variables of stable economic conditions, crises, and pandemics. The first research findings on differences in crisis, stable and pandemic times in the Asian stock market show that there is no significant difference in effect between stable times and during a crisis, but there are differences in the effect during stable and pandemic times. The second research finding states that the return on Asian market Shariah stocks has no influence on increasing or reducing the value of risk or value at risk. The third finding explains that Islamic stocks in Indonesia have a greater risk value during pandemics and crises than in stable times, but the effect of pandemic and crisis conditions is not as great as Islamic stocks in Asia as a whole. In order to stabilize markets and reduce risks, regulatory bodies and governments frequently employ a variety of actions during times of crisis. When applied to trading volume, risk, and return patterns, these findings can help determine the appropriate policy.
The Practice Characteristics of Authorized Heritage Discourse in Tourism: Thematic and Spatial
Authors: Jin Yang , Hou Bing , Kong Xiang
Published: June 2024

Under the influence of tourism and globalization, heritage production presents a new landscape. As a crucial framework for interpreting heritage, Authorized Heritage Discourse (AHD) has profound significance in discussing its practice characteristics in this context. Taking cities along the Jiangsu–Zhejiang section of the Grand Canal as a case study and drawing upon policy text, this study explores the practice characteristics of AHD in the tourism context. Results indicate that the thematic practices of AHD encompass protection and management, ecological construction, cultural production and inheritance, touristification, infrastructure and services, and marketing and cooperation, forming a clustering pattern with touristification as the central theme. The spatial characteristics manifest as multi-scale practices ranging from global to regional to local, each corresponding to diverse thematic characteristics. This study deepens the understanding of AHD in tourism and advances the research progress of heritage tourism. It also provides practical references for the utilization of urban heritage and the management of heritage tourism.
Histoplasmosis in Taiwan: Case Summary and Literature Review
Authors: Hsu Jui-Chi , Chang Po-Hsun , Tai Chien-Hsiang , Chen Yi-Chun
Published: June 2024

Histoplasmosis is a global infection caused by the thermally dimorphic fungus, Histoplasma capsulatum complex. It is endemic in the United States, as well as in Central and South America. In Taiwan, histoplasmosis is rare, with the first reported case not occurring until 1977. We summarized a total of 17 cases reported in Taiwan over the past 40 years and provided detailed descriptions for four probable indigenous cases. Due to the lack of rapid diagnostic tools and clinical suspicion, histoplasmosis may be underdiagnosed in Taiwan. We recognize that a limitation of our review is the lack of data on the environmental surveillance for H. capsulatum complex in Taiwan. Conducting a further phylogenetic analysis on both environmental and clinical isolates would provide valuable evidence for the region.
Removal of Iron and Copper Ions and Phenol from Liquid Phase by Membrane Based on Carbonaceous Materials
Authors: Przybyl Joanna , Bazan-Wozniak Aleksandra , Poznan Faustyna , Nosal-Wiercińska Agnieszka , Cielecka-Piontek Judyta , Pietrzak Robert
Published: June 2024

The present work reports an effective method for the removal of inorganic and organic pollutants using membranes based on different carbonaceous materials. The membranes were prepared based on cellulose acetate (18 wt. %), polyvinylpyrrolidone as a pore-generating agent (2 wt. %) and activated carbon (1 wt. %). Activated carbons were developed from residues after extraction of the mushroom Inonotus obliguus using microwave radiation. It has been demonstrated that the addition of activated carbon to the membranes resulted in alterations to their physical properties, including porosity, equilibrium water content and permeability. Furthermore, the chemical properties of the membranes were also affected, with changes observed in the content of the surface oxygen group. The addition of carbon material had a positive effect on the removal of copper ions from their aqueous solutions by the cellulose–carbon composites obtained. Moreover, the membranes proved to be more effective in the removal of copper ions than iron ones and phenol. The membranes were found to show higher effectiveness in copper removal from a solution of the initial concentration of 800 mg/L. The most efficient in copper ions removal was the membrane containing urea-enriched activated carbon.
Improving the Automatic Detection of Dropout Risk in Middle and High School Students: A Comparative Study of Feature Selection Techniques
Authors: Zapata-Medina Daniel , Espinosa-Bedoya Albeiro , Jiménez-Builes Jovani Alberto
Published: June 2024

The dropout rate in underdeveloped and emerging countries is a pressing social issue, as highlighted by studies conducted by The Organization for Economic Co-operation and Development. This study compares five feature selection techniques to address this challenge and improve the automatic detection of dropout risk. The methodological design involves three distinct phases: data preparation, feature selection, and model evaluation utilizing machine learning algorithms. The results demonstrate that (1) the top features identified by feature selection techniques, i.e., those constructed through feature engineering, proved to be among the most effective in classifying student dropout; (2) the F-score of the best model increased by 5% with feature selection techniques; and (3) depending on the type of feature selection, the performance of the machine learning algorithm can vary, potentially increasing or decreasing based on the sensitivity of features with higher noise. At the same time, metaheuristic algorithms demonstrated significant precision improvements, but there was a risk of increasing errors and reducing recall.
Hyers–Ulam Stability of Isometries on Bounded Domains–III
Authors: Choi Ginkyu , Jung Soon-Mo
Published: June 2024

The question of whether there is a true isometry that approximates the ε-isometry defined on a bounded set has long interested mathematicians. The first paper on this topic was published by Fickett, whose result was subsequently greatly improved by Alestalo et al., Väisälä and Vestfrid. Recently, the authors published some papers improving the previous results. The main purpose of this paper is to improve all of the abovementioned results by utilizing the properties of the norm and inner product for Euclidean space.