bluuebunny/crossref_metadata_2025 huggingface dataset:
Is it safe to discontinue anticoagulant after surgical treatment of varicose vein disease, which caused pulmonary embolism?
Authors: Kipiani T. G. , Kozlova V. V. , Lobastov K. V.
Published: May 2024

Superficial vein thrombosis, which is mostly caused by lower extremity varicose vein disease, can be complicated by pulmonary embolism. At the same time, the optimal duration of anticoagulant therapy for pulmonary embolism originated from varicose vein thrombosis is still under debate. On the one hand, the presence of varicose veins is considered a small risk factor for the development of venous thromboembolic events, which persistence determines an increased risk of relapse and requires prolonged anticoagulant therapy. On the other hand, elimination of varicose veins is associated with reduced risk of subsequent venous thromboembolic events. The article describes a clinical case of recurrent pulmonary embolism after surgical treatment of varicose vein disease, which caused primary pulmonary embolism. A 45-year-old patient suffering from left lower extremity varicose vein disease for 5 years was admitted to the intensive care unit with suspected pulmonary embolism. The further examination revealed signs of thrombotic occlusion of the segmental and subsegmental branches of the pulmonary arteries bilaterally and the middle lobe branch of the right pulmonary artery, as well as signs of the right-sided heart overload. In this case, pulmonary embolism was found to originate from thrombosis of the trunk of the great saphenous vein ofthe left lower extremity with a proximal border at the level of the lower leg. No signs of deep vein involvement were detected. The parenteral anticoagulant therapy initiated in the hospital was followed by switching to therapeutic doses of rivaroxaban. The signs of recanalization of involved veins were identified after 6 months of treatment, and it was decided to perform endovenous laser coagulation of the trunk of the great saphenous vein combined with mini-phlebectomy of varicose tributaries on continuous oral anticoagulant therapy. The rivaroxaban therapy was completed a month after intervention. However, 7 days later the patient was diagnosed with repeated symptomatic pulmonary embolism, which originated from thrombosis of the left popliteal vein. It was recommended to resume anticoagulant therapy of indefinite duration. The article discusses the issues of optimal duration of treatment for pulmonary embolism originated from thrombosis of superficial varicose veins, as well as the possible timing of completion of anticoagulant therapy after the intervention.
Optimization of treatment of patients with inguinal hernia in combination with recurrence of varicose veins
Authors: Milyukov V. E. , Chernookov A. I. , Kandyba S. I. , Bartosh N. O. , Dondup O. M. , Atayan А. A. , Ramazanov A. A. , Pshmakhova A. Z. , Shadyzheva T. I.
Published: May 2024

Introduction. In recent years, surgeons have increasingly used combined operations in patients with inguinal hernias and recurrent varicose veins. However, it is necessary to justify the choice of the type and volume of the main and concomitant stages of combined surgery, depending on the individual characteristics of both diseases.

Aim. Optimization of surgical treatment of patients with inguinal hernias in combination with relapses of varicose veins.

Materials and methods. The study included 39 patients aged 35 to 78 years with inguinal hernias and RVB. Of these, 21 patients who underwent combined operations were included in the main group. The control group included 18 patients who underwent staged hernioplasty, and then after 1–26 months, operations for RVB, or interventions were performed in reverse order. A comparative assessment of the duration of operations, the level of postoperative pain, immediate and long-term results, and the number of complications of uncorrected diseases in two-stage treatment was carried out.

Results and discussion. Performing combined operations in this category of patients does not lead to an increase in the level of postoperative complications, it is accompanied by an average increase in the duration of surgery by 33.6 minutes and an increase in the intensity of postoperative pain by 0.8 points, a decrease in temporary disability by 1.2 times.

Conclusions. Performing combined operations is the optimal intervention in patients with inguinal hernias with concomitant recurrence of varicose veins. The use of combined operations makes it possible to simultaneously eliminate both diseases and exclude the development of complications from an uncorrected disease, which, with two-stage treatment, was observed in 11.1% of cases and required emergency operations.
Combined use of oral and topical forms of phlebotonics after endovasal laser coagulation
Authors: Chubirko Yu. M. , Kasyanov I. O.
Published: May 2024

Introduction. The combination of endovasal laser coagulation and miniphlebectomy is actively used in the treatment of Chronic venous diseases, however, the question of improving the management of such patients in the postoperative period remains actual.

Aim. To evaluate the effectiveness of the combined use of oral and topical forms of phlebotonics after endovasal laser coagulation.

Materials and methods. The study was conducted in 60 patients after surgery divided into 2 comparable (n = 30). The group 1 was treated with MPFF 1000 mg (Detralex) once a day during the perioperative period (10 days before surgery and up to 2 months after) and additionally topical Detragel daily 3 times a day for 10 days after the intervention. The group 2 used heparin topical form for 10 days after surgery. Control was carried out on the 1st day, 10th day after surgery, as well as after 3 and 6 months.

Results. In group 1, there was a statistically more significant decrease in the level of pain on days 1 and 10 after surgery (p ≤ 0.05), while the frequency of hyperpigmentation at months 3 and 6 after surgery was also less presented.

Conclusions. The combination of endovasal laser coagulation and miniphlebectomy while taking MPFF and a gel based on heparin, escin and essential phospholipids is accompanied by less severe pain and the level of hyperpigmentation in the postoperative period.
Chronic venous diseases and obesity: pathogenetically based treatment and prevention options
Authors: Boldin B. V. , Boldin B. V. , Varich G. A. , Dzhenina O. V. , Abdosh R.
Published: May 2024

This literature review analyzes relationships and correlations between obesity and chronic venous diseases. The search of scien tific publications was carried out in the Cochrane Library, PubMed, Medscape and Medline databases in accordance with the PRISMA guidelines. The review includes only publications, which were particularly relevant to our focus of research and where a significance difference between “experience and control” groups was found based on the results of statistical analysis. All studies included in the analysis defined obesity as a body mass index of 30.0 kg/m2 or more, and overweight as a BMI from 25 to 30 kg/m2 according to the criteria of the World Health Organization. The findings of publication analysis show that excess body weight, and especially obesity, is a major independent risk factor for the development and progression of chronic venous diseases and their complications. In addition, a direct cause-and-effect relationship between body weight and the severity of chronic venous insufficiency was observed. Increased intra-abdominal pressure associated with the visceral fat deposition is one of the key features of the pathogenesis of chronic venous diseases in patients with overweight and obesity. In this context, bariatric surgery, after which weight loss correlates with falling into a lower clinical class of chronic venous diseases is the most effective method for improving phlebological status. Along with bariatric surgery, the pharmacotherapeutic options are considered in patients with chronic venous diseases with underlying overweight and burdened comorbidities anamnesis. In this regard, the role of hesperidin combined and diosmin that have been shown to be most effective phlebotropic drug is discussed. Recent studies demonstrate that hesperidin has independent pluripotent properties, among which the mechanisms of action of this substance on lipid metabolism accompanied by a decrease in subjects’ body weight and visceral fat volume are a matter of interest. After completion of full-fledged clinical studies this action of hesperidin can be implemented in various treatment-and-prophylactic protocols on the management of patients with chronic venous diseases, related to underlying overweight and morbid obesity. Venarus® contains two micronized components hesperidin and diosmin at standardized dosages: 10% hesperidin and 90% diosmin, which can be used as an argument in favour of choosing this drug to treat patients with chronic venous diseases, related to underlying obesity or overweight.
Experience of using homeopathic ointment in the treatment of patients with anal itching
Authors: Lichman L. A. , Katorkin S. E. , Andreev P. S. , Davydova O. E.
Published: May 2024

Introduction. Anal contact or conduction in the anal canal and rectum is a common condition in the coloproctological field, occurring in 5% of the population that affects this country. Treatment consists of hygiene and the use of topical steroids, antibacterial and antifungal agents. No generally accepted attitude towards a private person has been developed.

Aim. To study the effectiveness of using homeopathic ointment in the treatment of patients with anal itching.

Material and methods. A prospective comparative randomized study was conducted in a specialized advisory center of the Clinics of Samara State Medical University. The study included 96 patients with anal itching without fungal infection of the perianal skin and concomitant purulent pathology. In the main group (n = 46), treatment was carried out using homeopathic ointment in the perianal area 2–3 times a day for 14 days. In the control group (n = 50), treatment was carried out with topical steroid ointments 2–3 times a day for 14 days.

Results and discussion. From the data obtained on the use of homeopathic ointment, it follows that it is not inferior in effectiveness to topical steroid ointments in reducing symptoms of the disease (Student’s t-test = 0.35; p > 0.05 and Student’s t-test = 0.28; p > 0.05), and by the number of relapses (χ2 = 0.535; p > 0.05).

Conclusion. The use of homeopathic ointment for topical application appears to be a promising new treatment for patients with anal itching and is as effective as topical steroid ointments.
Endovenous laser obliteration of the lower extremity veins: there is a time and place
Authors: Zubkov D. S.
Published: May 2024

.
How to improve the health care quality for patients with lower extremity varicose vein disease? Book Review: Borsuk D.A., Fokin A.A. Strategies to improve outcomes of minimally invasive treatment of varicose veins of the lower extremities. Moscow: DPK Press; 2023. 300 p. (In Russ.)
Authors: Bogachev V. Yu.
Published: May 2024

The presented paper reviews the monograph Strategies to improve outcomes of minimally invasive treatment of varicose veins of the lower extremities by D.A. Borsuk and A.A. Fokin intended to be used by surgeons, cardiovascular surgeons, ultrasonic medical investigation specialists, resident physicians, graduate students and students of medical universities. The need to publish the book is determined by the urgency of the problem at issue. The reviewer discusses the results presented by the authors of their own comparative and non-comparative, randomized and non-randomized, prospective and retrospective, clinical and morphological single-centre trials. The monograph’s review summarized its theoretical and practical value for treatment and preventive surgery facilities providing care to patients with lower extremity varicose vein disease.
Research on the Constitutional Reform of Kyrgyzstan and Its Influence on Political Transformation
Authors: Tian Fuchang
Published: May 2024

In the 1990s, Union Republic of the Soviet Union Kyrgyzstan passively began the process of national independence and political transformation. As a country in transition, all the constitutions in Kyrgyzstan not only regulate the political life of the country, but also epitomize the practice of political transition. By combing the history of political transformation and constitutional reform in Kyrgyzstan, this paper analyzes the main contents and characteristics of the successive constitutional amendments in Kyrgyzstan by using the methods of literature analysis, text analysis and comparative study, and focus on analyzing the impact of constitutional reform on political transformation.
reducción del financiamiento público de los partidos políticos en México: de demanda ciudadana a iniciativa populista
Authors: Flores Díaz Jorge Gerardo
Published: May 2024

En esta investigación se estudia la propuesta de modificar el artículo 41 constitucional con el objetivo de reducir el financiamiento público de los partidos políticos en México. Se sostiene que inicialmente fue una demanda ciudadana: en 2012 fue impulsada por las organizaciones sociales que presentaron esta propuesta a los candidatos y partidos contendientes en las elecciones federales, y en 2017 fue una demanda ciudadana que surgió ante la emergencia derivada de los sismos de ese año. Sin embargo, desde que el partido MORENA accede al poder (2018) esta iniciativa forma parte de una estrategia populista encabezada por el presidente de la República que busca debilitar a las instituciones del Estado autónomas y a todo tipo de oposición política.
Investigation on Effects and Properties of Concrete Structure after Exposed to Fire
Authors: Dhoke Prof. S. V.
Published: May 2024

Abstract: The integrity and strength of the materials used in reinforced concrete structures are highly influenced by their exposure environment. Exposing the building materials to high temperature changes their performance. The change in the performance is a result of the change in the material properties. When subjecting a building material to fire, the occurring damage depends on the severity of the fire in terms ofthe fire temperature and time of exposure. This study investigates the effects of fireexposure on the set of RC beams. Through controlled experiments, varyingtemperatures from 3000C to 7000C areapplied to RC beams, analyzing changes in compressive strength, spalling, andmicrostructure by using rebound hammer,UPV meter and applying two-point loading in UTM. Results indicate a significantreduction in compressive strength with increasing fire temperature, attributed to thermal degradation of cement paste and aggregate. Additionally, changes inmicrostructure, such as pore structure alterations and formation of cracks, are observed. Also, few of RC beams were strengthened using GFRP sheets as a U- shaped wrapping to entire beam and U- shaped wrapping at certain intervals. The strengthened specimens are again tested in UTM for two-point loading, the results of the tests showed the feasibility of rehabilitating RC beams exposed to fire using GFRP plates.U-shaped wrapping to entire beam showed the good performance
Automatic Power Factor Compensation (APFC) for Industrial Power Use to Minimize Penalty
Authors: Kotresh Prof. Mr. S.
Published: May 2024

Abstract: In this proposed system, two zero crossing detectors are used for detecting zero crossing of voltage and current. The project is designed to minimize penalty for industrial units using automatic power factor correction unit. The microcontroller used in this project belongs to 8051 family. The time lag between the zero-voltage pulse and zero-current pulse is duly generated by suitable operational amplifier circuits in comparator mode is fed to two interrupt pins of a microcontroller. The program takes over to actuate appropriate number of relays from its output to bring shunt capacitors into load circuit to get the power factor till it reaches near unity. The capacitor bank and relays are interfaced to the microcontroller using a relay driver. It displays time lag between the current and voltage on an LCD. Furthermore, the project can be enhanced by using thyristor control switches instead of relay control to avoid contact pitting often encountered by switching of capacitors due to high in rush current
Design and Analysis of ONLINE Voting System
Authors: Vigneshwar Merugu
Published: May 2024

A democratic country encourages voting system to decide the future leader. Traditional voting system offers lack of user friendliness in review of votes and voters’ identity security. In this present work, for the first time, a web-based voting architecture is designed and developed. The system has a login page, registration page, and dashboard page for voters to access in a user-friendly manner. The login page is the first page that users see when they access the system through registered mobile number, password, and role. The role is used to distinguish between voters and groups or candidates. The dashboard page is the display unit to exhibit voters’ profile information such as name, image, voting status, and mobile number on the left side of the page. On the right side of the page, there will be a list of groups or candidates whom they can cast their votes. In our proposed system, it is ensured that each voter can only vote once and that duplicate voting is not possible. The system uses password protected voting system and Black Box to administer the security issues for inculcating integrity of the voting process. The system is designed to provide a secure and user-friendly interface for voters to cast their votes online and henceforth the architecture will save the time, energy, and costs. T
A Fake Products Identification by Using Blockchain
Authors: Nagarkar Gaurav
Published: May 2024

Abstract: Counterfeiting of products is a significant challenge across various industries, leading to economic losses and risks to consumer safety. This paper proposes a novel approach to combat counterfeit products using blockchain technology. By leveraging the immutable and transparent nature of blockchain, a framework is devised to authenticate products throughout their lifecycle. The system utilizes unique identifiers assigned to each product during manufacturing, which are then recorded on a blockchain ledger. Through a decentralized network of nodes, stakeholders including manufacturers, distributors, retailers, and consumers can verify the authenticity of products in real-time. Smart contracts are employed to automate verification processes, ensuring integrity and efficiency. Additionally, the framework incorporates mechanisms for data privacy protection, ensuring sensitive information remains secure. Through empirical analysis and simulations, the effectiveness and scalability of the proposed solution are evaluated. Results demonstrate a significant reduction in counterfeit incidents and enhanced trust among stakeholders. This research contributes to the advancement of anti-counterfeiting measures, offering a robust solution to safeguard product authenticity in the digital age.
To Study Significance and Impact of Social Media Marketing in CRM
Authors: Katyal Drishti
Published: May 2024

Abstract: Social media is now a crucial component of contemporary communication, and the way peoplecommunicate with one another has changed dramatically. Being a platform for communicatingwith customers and creating relationships, social media has also become an important component of customer relationship management (CRM) for organisations. As a result, social media marketing has changed as a critical tactic for firms seeking to reach out to customers and build long-term relationships. One of the primary benefits of CRM social media marketing is that it enables organisations to communicate with their customers in a more personal and interactive manner. Customers can use social media platforms to ask questions, provide comments, and share their experiences with a brand, allowing businesses to reply in a quick and effective manner. This type of two- way communication fosters customer and business trust, resulting in enhanced customer satisfactionand retention. Social media is now a crucial component of contemporary communication, and the way people interact with their customers, offering unparalleled opportunities for engagement and relationship building.
Tinjauan Aksesibilitas Masjid Raya Baiturrahman Banda Aceh bagi Penyandang Disabilitas
Authors: Nadhifa Nada , Rahmi Marlisa , Alfitri Mira
Published: May 2024

Abstract. Public buildings are formed based on public activities and needs. The building must meet the needs of users as a whole. One of the public buildings most needed by the community is a house of worship. For the people of Aceh, one of the houses of worship that is quite often visited is the Baiturrahman Great Mosque, which is located in the center of Banda Aceh City. The existence of disability issues raises questions about the needs of persons with disabilities which makes this question the basis of this research. The question in this research is how accessible is it in a public building, especially for persons with disabilities. The research method used in this research is descriptive qualitative. Data collection is done by observation. that the results of the study show that the Baiturrahman Grand Mosque in Banda Aceh, has not fully implemented the concept of a disability-friendly building. This is because the availability of supporting facilities for persons with disabilities has not been maximized, and some of the facilities provided cannot be used properly, so that when viewed from the perspective of the needs of persons with disabilities, this building cannot operate optimally.
Interpretasi Kaidah Arsitektur Islam Pada Desain Rumah Tradisional Aceh
Authors: Annisa Astrid , Ali Nasution Mufti
Published: May 2024

Abstract. Aceh, as a province deeply rooted in Islamic Sharia, consistently applies the teachings of Islam in every aspect of community life. Aceh has customs and culture based on Islamic teachings. Traditional Acehnese houses, commonly known as 'Rumoh Aceh,' represent the traditional homes of the Acehnese people, conveying meanings and philosophies related to the culture and customs of the Acehnese community. This research aims to identify and examine the compatibility of traditional Acehnese house designs based on Islamic values and architectural principles. The study employs a descriptive-qualitative method to uncover the application of Islamic architecture in traditional Acehnese house structures. The research findings indicate that traditional Acehnese houses adhere to Islamic architecture principles. Every element of the building and the design of spaces, all grounded in the teachings of Islam.
Pengaruh Desain Interior terhadap Kenyamanan Pengguna di Perpustakaan UIN Ar-Raniry Banda Aceh
Authors: Naufal Muhammad , Putri Rachmadani Nisa , Alfitri Mira
Published: May 2024

Abstract. The college library is a place for students to be used as   a science-based recreation area. To fulfill this, a comfort is needed for visitors, especially students, to feel at home and feel / want to continue to linger while in the library. Wicaksana (2016) defines comfort as a relaxed condition, where pain is not felt between all limbs. Factors from the interior of the library also greatly influence students to feel more comfortable when they are in the room in the library. The purpose of this study is to determine the level of user comfort when in the UIN Ar-R aniry library room, especially in the reading area / room which includes lighting, air, and sound efficiency (acoustic) factors.  This research uses qualitative methods with descriptive data analysis methods (data coding) and calculations based on the results of questionnaires (Likert scale), observation, and documentation.   The results showed that the average visitor was a student of UIN Ar-Raniry and chose to visit in groups, with a frequency of visits ranging from 1 to 3 visits, and a visit time of less than or for 2 hours. Serta prefers to visit during the day (14.00 WIB) to afternoon (16.30 WIB). Common activities are doing assignments or looking for references with the reading room as the most visited area. Based on open questions to respondents and has been categorized, the comfort factor is the reason users want to stay longer in the UIN Ar-Raniry library. Respondent also feels comfortable in terms of lighting and air both naturally and artificially. But for the noise level, occasionally respondents feel a little disturbed due to the sound generated from other users' activities.
Foundational Exploration and Key Properties of Refined Intuitionistic Q-fuzzy Set: A Comprehensive Study on Mathematical Framework and Set-Theoretic Operations
Authors: Saeed Muhammad , Razaq Fatima
Published: May 2024

Fuzzy set theory, allows for degrees of membership and introduces
membership functions to model imprecise information. Q-fuzzy set theory
extends this by incorporating linguistic quantifiers for a flexible
representation of uncertainty. Intuitionistic fuzzy set theory, adds a
separate degree of non-membership for a more comprehensive portrayal of
uncertainty. Refined intuitionistic fuzzy set theory, further enhances
precision by subdividing membership and non-membership values,
addressing the limitation of singular assignments in representing
uncertainty. This research delves into the foundational aspects of
refined intuitionistic Q-fuzzy set (RIQFS) and investigates several key
properties associated with this specialized mathematical framework, like
subset, equal set, null set, and complement set within the framework of
refined intuitionistic Q-fuzzy set. The investigation also involves
conceptualizing basic settheoretic operations, including union,
intersection, extended intersection, restricted union, restricted
intersection, and restricted difference. Furthermore, the analysis
explores fundamental laws, elucidating each with illustrative examples
to facilitate a clearer understanding.
Persistent inner tepals and wings protect developing seeds of Rheum nanum from insect herbivory in Central Asian cold deserts
Authors: Li Yuting , Mamut Jannathan , Xie Kaiqing , Zhao Jing , Tan Dun-Yan
Published: May 2024

Although the postdispersal function of fruit appendages has been
reported, little is known about their protective/defensive functions. In
this context, diaspores with appendages (persistent inner tepals and/or
fruit wings) that experienced predispersal herbivory by insects in
natural populations of Rheum nanum were investigated. The seed abortion
percentage, seed and embryo masses, and germination of seeds from
diaspores with different categories of insect herbivory were measured
and compared. Predispersal insect herbivory of R. nanum diaspores was
prevalent in the four natural populations, but the percentage of
diaspores with appendages (persistent inner tepals and and/or fruit
wings) damaged by insects was significantly higher than that of
diaspores with the pericarp damaged by insects. Seeds from diaspores
with gnawed appendages experienced significantly less damage than those
with gnawed pericarps. Importantly, we conclude that fruit appendages of
Rheum nanum help to mechanically protect developing seeds from
predispersal insect herbivory.
Dauresorcinols A and B, Two Pairs of Merosesquiterpenoid Enantiomers with New Carbon Skeletons from Rhododendron dauricum
Authors: Zhang Hanqi , Gao Biao , Zheng Guijuan , Feng Yuanyuan , Liu Zhijun , Yao Guangmin
Published: May 2024

Five pairs of new merosesquiterpenoid enantiomers, named dauresorcinols
A−E (1−5), were isolated from the leaves of
Rhododendron dauricum. Their structures were elucidated by
comprehensive spectroscopic data analysis, quantum chemical
calculations,
Rh(OCOCF)-induced
ECD, and single-crystal X-ray diffraction analysis. Dauresorcinols A
(1) and B (2) possess two new merosesquiterpene
skeletons bearing an unprecedented
2,6,7,10,14-pentamethyl-11-oxatetracyclo[8.8.0.0.0]octadecane
and a caged
15-isohexyl-1,5,15-trimethyl-2,10-dioxatetracyclo[7.4.1.1.0]pentadecane
motif, respectively. Plausible biosynthetic pathways of
1−5 are proposed involving key oxa-electrocyclization
and Wagner−Meerwein rearrangement reactions. (+)/(−)-1 and
3−5 showed potent α-glucosidase inhibitory activity, 3
to 22 times stronger than acarbose, an antidiabetic drug targeting
α-glucosidase. Docking results provide a basis to design and develop
merosesquiterpenoids as potent α-glycosidase inhibitors.
Potentiating light-harvest tactics through A-D-A structure: repolarization tumor associated macrophage through phototherapy
Authors: Liu Pai , Cao Jiayu , Zhao Xinyue , Tian Mengyan , Li Yaning , Ma Chunyan , Yang Tianyue , Liu Yi
Published: May 2024

Aiming to decrease the recurrence of tumors and achieve patients’
satisfactory, the elicitation of immunotherapy and integrated
synergistic employment anew bright new down in oncotherapy, yet an
emergently challenging task. Especially, tumor-associated macrophages
(TAMs) regulation though light-induced photodynamic and photothermal
therapy (PDT and PTT) was regarded as a powerful approach, which focused
on systemic immune instead of tumor itself. Herein, this study published
an acceptor-donor-acceptor (A-D-A) aggregation-induced emission
luminogens (AIEgens), named TPA-2CN, which was applied as
photosensitizer (PSs) and photothermal agent (PTA). Attributing to the
A-D-A structure and AIE property, TPA-2CN owned higher molar absorption
coefficient and perfect templates in regulating radiative and
nonradiative transitions, which maximally utilized excited energy. The
generation of type I reactive oxygen pro-moted its application in
hypoxia tumor sites and the combination of hyperpyrexia forcefully
induced macrophages to polarization to-wards immune responses M1
phenotype. Both in vitro and in vivo, the successful reversion and
reprogramming of immune microenvironment was impressively proved. This
finding optimally concentrated immune therapy, PDT and PTT as one, and
exhibited excellent synergistic therapeutic effects with good biosafety.
Transseptal approach versus retrograde aortic approach in mapping and ablation of ventricular arrhythmias from anterolateral papillary muscles
Authors: Jiang Chen-Xi , LI Shao-Long , Li Mengmeng , Tang Ribo , Sang Caihua , Wang Wei , Dong Jianzeng , Long Deyong , Zei Paul , Ma Chang Sheng
Published: May 2024

Background: The anterior and lateral position of the
anterolateral papillary muscle (ALPM) has found to be reached with
better catheter stability and less mechanical bumping via the
transseptal (TS) compared to the retrograde aortic (RA) approach.
Aim: To compare the TS and RA approaches on mapping and
ablation of ventricular arrhythmias (VAs) arising from ALPMs.
Methods: Thirty-two patients with ALPM-VAs undergoing mapping
and ablation via the TS approach were included and compared with 31
patients via the RA approach within the same period. Acute success was
compared, as well as other outcomes including misinterpreted mapping
results due to bumping, radiofrequency (RF) attempts, procedural time
and success rate at 12 months’ follow-up. Results: Acute
success was achieved in more cases in the TS group (96.4% vs 72.0%,
P=0.020). During activation mapping, bump-provoked premature ventricular
complexes (PVCs) misinterpreted as clinical PVCs were more common in the
RA group (30.0% vs 58.3%, P=0.036), leading to more RF attempts
(3.5±2.7 vs 7.2±6.8, P=0.006). Suppression of VAs were finally achieved
in the unsuccessful cases by changing to the alternative approach, but
the procedural time was significantly less in the TS group (90.0±33.0 vs
113.7±41.1min, P=0.027) with less need to change the approach, although
follow-up success rates were similar (75.0% vs 71.0%, P=0.718).
Conclusion: A TS rather than RA approach as the initial
approach appears to facilitate mapping and ablation of ALPM-VAs,
specifically by decreasing the possibility of misleading mapping results
caused by bump-provoked PVC, and increase the acute success rate
thereby.
Modelling and Estimation of Above Ground Biomass and Carbon Stock of Pinus Roxburghii Dominated Forest Using Sentinel-2 Imagery in Shreenagar Hill, Nepal
Authors: Bashyal Sagar , Gautam Jeetendra , Subedi Bibek , Timilsina Pooja
Published: May 2024

Aim: To model and estimate the total above ground biomass (AGB) of
forest with the best model out of five different regression models
Location: Shreenagar Hill Forest, Tansen Municipality, Nepal Time
Period: During the month of July, 2023 Major Taxa Studies: Pinus
roxburghii Methods: Sentinel-2 satellite imagery and field-measured AGB
at plot level were used. Field data were collected from a total of 26
sample. Randomly chosen 18 sample plots (SPs) (70%) were used to
generate the model and remaining 8 SPs (30%) for validation of
developed model. Using various bands with 10m spatial resolution, eleven
VIs were calculated & correlated with field measured AGB at plot level.
Results & Main Conclusions: Evaluating the fit statistics, quadratic
regression model using NDVI with correlation coefficient (R) 0.92,
coefficient of determination (R^2) 0.86, AIC (161.13) & BIC (164.69)
was found as the best model. Predicted value of AGB from best model and
observed value of AGB from field were used for model validation. Root
mean square error (RMSE), R & R^2 were found as 13.3594 t.ha-1per
plot, 0.9597 and 0.9211 respectively during the model validation.
Therefore, the quadratic regression model with NDVI as best fit model
was used to estimate the total AGB and carbon stock (CS) of study area.
The average value of AGB & CS (including no vegetation area) for total
study area were found 192.403 & 90.429 t.ha-1 respectively. The value
of AGB & CS range from 0 to 233.451 & 0 to 109.722 t.ha-1 per pixel
respectively. The benefits, possibilities, and effectiveness of
combining Sentinel-2 VIs with field data to forecast biomass are
demonstrated by this work. To reduce the estimation error & make wider
application of research, very large sample size can be chosen by future
researchers.
A novel method for calculating the dynamic reserves of tight gas wells considering stress sensitivity is under consideration. - Take the ZT block in Northwest Sichuan as an example
Authors: Chen Chang-Hao , Luo Jing , Cao Jian , Li Xu-Chen , Cai Lin-Feng , Zhu Tan-Yin
Published: May 2024

The accuracy of dynamic reserve calculation in gas fields is of
significant importance for the rational and efficient development of oil
and gas fields, as well as the establishment of gas well production
allocation schemes. The reservoir in the ZT block in the northwest of
Sichuan is tight and highly heterogeneous, with complex gas-water
distribution and significant differences in gas well test production
rates and rapid decline rates. In order to accurately calculate the
dynamic reserves of such tight water-bearing gas wells, this study
focuses on the tight water-bearing gas reservoirs in the ZT block in the
northwestern region of Sichuan. Rock core X-ray diffraction experiments,
constant rate mercury injection experiments, and reservoir rock stress
sensitivity experiments were conducted. Based on the experimental
results, corrections were made to the porosity and permeability of rock
samples under effective stress conditions using a binary linear
regression method. These corrected parameters were then incorporated
into the water-sealed gas material balance method, establishing a new
method for calculating dynamic reserves in water-bearing tight gas
reservoirs under stress-sensitive conditions. Utilizing reservoir
parameters and production data from the ZT block, the results of the
material balance method, well testing analysis method, and mathematical
statistical method were compared with the results obtained using the new
method. The dynamic reserve calculations for water-bearing tight gas
reservoirs considering stress-sensitive conditions showed smaller
relative errors and more accurate results.
Effect of Maternal Prebiotic Supplementation on Human Milk Immunological Composition.
Authors: Macchiaverni Patricia , Divakara Nivedithaa , Saraswati Chitra , Dempsey Zac , Garssen Johan , Silva Desiree T. , A Jeffrey Keelan , T Claus Christophersen , N Matthew Cooper , Prescott Susan , Palmer Debra J , Verhasselt Valerie
Published: May 2024

Background: Immunomodulatory proteins in human milk (HM) can
shape infant immune development. However, strategies to modulate their
levels are currently unknown. This study investigated whether maternal
prebiotic supplementation alters the levels of immunomodulatory proteins
in HM. Methods: The study was nested within the SYMBA
double-blind randomised controlled trial (ACTRN12615001075572), which is
investigating the effects of maternal prebiotic (scGOS/lcFOS)
supplementation from <21 weeks gestation during pregnancy
until 6-months postnatal during lactation on child allergic disease
risk. Mother-child dyads receiving prebiotics (n=46) or placebo (n=54)
were included in this study. We measured the levels of 24
immunomodulatory proteins in HM collected at 2, 4 and 6 months.
Results: Cluster analysis showed that the overall
immunomodulatory protein composition of milk samples from both groups
was similar. Prebiotic-supplemented women had decreased levels of TGF-β1
at 2 months, IgG1 at 4 months and sCD14 at 6 months (p=0.03, 0.03 and
0.04, respectively). IL-5 levels were increased in the prebiotic group
compared to the control group at 4 and 6 months (p=0.02 and 0.04,
respectively). After adjustment for multiple comparisons, the
statistical differences between the prebiotic and placebo groups were no
longer present (p>0.05). Conclusion: This study is
the first to comprehensively trial scGOS/lcFOS intake during pregnancy
and indicate potentially altered levels of immunomodulatory proteins in
HM. Future research will elucidate the significance of change in milk
content in immunomodulatory compounds in the prevention of allergy risk
(and beyond), filling a major gap in dietary advice to pregnant and/or
lactating women.
Differential atrophy along the longitudinal hippocampal axis in Alzheimer's disease
Authors: Morais-Ribeiro Rafaela , Almeida Francisco , Coelho Ana , Oliveira Tiago
Published: May 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder
that primarily affects the hippocampus. Since hippocampal studies have
highlighted a differential subregional regulation along its longitudinal
axis, a more detailed analysis addressing subregional changes along the
longitudinal hippocampal axis has the potential to provide new relevant
biomarkers. This study included structural brain MRI data of 583
participants from the Alzheimer’s Disease Neuroimaging Initiative
(ADNI). Cognitively normal (CN) subjects, mild cognitively impaired
(MCI) subjects and AD patients were conveniently selected considering
the age- and sex-match between clinical groups. Structural MRI
acquisitions were pre-processed and analysed with a new longitudinal
axis segmentation method, dividing the hippocampus in three subdivisions
(anterior, intermediate, and posterior). When normalizing the volume of
hippocampal sub-divisions to total hippocampus, the posterior
hippocampus negatively correlates with age only in CN subjects (r =
-0.31). The longitudinal ratio of hippocampal atrophy (anterior
sub-division divided by the posterior one) shows a significant increase
with age only in CN (r = 0.25). Overall, in AD the posterior hippocampus
is predominantly atrophied early on. Consequently, the
anterior/posterior hippocampal ratio is an AD differentiating metric at
early disease stages with potential for diagnostic and prognostic
applications.
Trilobatin targets Nrf2 to ameliorate lipopolysaccharide-induced depressive-like behavior: Involvment of microbiota-gut-brain axis
Authors: Gao Jianmei , Yi Yang , Wei Jiajia , Gong Miaoxian , Deng Weikun , Hou Fangqin , Zhang Yuandong , Gong Qihai
Published: May 2024

Abstract Background and Purpose: Activation of Nrf2 holds great promise
for treating major depressive disorder (MDD). Trilobatin (TLB) is a
naturally occurring food additive conferring robust neuroprotection with
Nrf2 activation potency. This study was designed to explore whether TLB
is able to overcome MDD, and the role of Nrf2 in the antidepressant
effect of TLB. Experimental Approach: Mice and primary hippocampal
astrocytes challenged with lipopolysaccharide (LPS) were used to
decipher the effects of TLB on MDD. Nrf2-deficient mice were treated
with TLB and fecal microbiota transplantation (FMT) to validate the
potential targets of ICS Ⅱ on ALI. Key results: TLB ameliorated
depressive-like behavior in LPS-induced MDD mouse model. Single-cell RNA
sequencing analysis of the hippocampus revealed that astrocytes
exhibited distinct MDD-related clustering with increased Nrf2 in the
antidepressant effect of TLB. TLB directly bound to Nrf2 and increased
Nrf2-antioxidant response element (ARE) binding activity, which
ultimately restored mitochondrial function, reduced oxidative stress and
neuroinflammation. TLB improved intestinal microbiota dysbiosis and
attenuated intestinal barrier through increasing expressions of the
tight junction proteins. Fecal microbiota transplantation from
TLB-treated mice also ameliorated depression-like behavior after LPS
insult. Furthermore, by using genetically modified Nrf2-knockout mice,
we validated that the antidepressant effect of TLB were Nrf2/ARE
signaling dependent, suppressing astrocytes activation and gut
microbiota dysbiosis. These favorable effects of TLB were abrogated in
Nrf2 deficiency mice. Conclusions and implications: Our results reveal a
new-found pharmacological property of TLB: serves as a novel and
naturally-occurring Nrf2 activator to conquer MDD through modulating
microbiota-gut-brain axis.
“Evaluating Triplet Regimens for Advanced Biliary Tract Cancer: A Meta-analysis of Safety and Efficacy Profiles”
Authors: Hasibuzzaman Md. Al , Zakaria Faiza , Ashkar Anusha , Baig Mirza Mehmood Ali , Fauzia Taqia , Irfan Shayan Ali , Umer Muhammed
Published: May 2024

Objective: Biliary Tract Cancer (BTC) is a significant health
concern with limited resectable cases. This meta-analysis assessed the
safety of triplet regimens for advanced BTC, specifically gemcitabine,
cisplatin, nab-paclitaxel, and gemcitabine, oxaliplatin, erlotinib,
along with their associated adverse events. Method: Following
PRISMA guidelines, we systematically reviewed PubMed/Medline, Google
Scholar, and the Cochrane Library from inception to November 2022.
Results: Our analysis of 5 studies favored
Gem+Cisplatin+nab-Paclitaxel over GEMOX-T in terms of safety and adverse
events. Qualitative analysis of 7 studies (491 patients) showed that
Gem+Cisplatin+nab-Paclitaxel also outperformed in median overall
survival, progression-free survival, and response rates.
Conclusion: This study suggests that
Gem+Cisplatin+nab-Paclitaxel is a safer and more effective treatment
than GEMOX-T for advanced BTC. It exhibits superior outcomes in terms of
survival and response rates. Further research should focus on optimizing
treatment regimens to reduce adverse effects in advanced BTC patients.
A framework for fluid motion estimation using a constraint-based refinement approach
Authors: Doshi Hirak , Nori Uday Kiran
Published: May 2024

Physics-based optical flow models have been successful in capturing the deformities in fluid motion arising from digital imagery. However, a common theoretical framework analyzing several physics-based models is missing. In this regard, we formulate a general framework for fluid motion estimation using a constraint-based refinement approach. We demonstrate that for a particular choice of constraint, our results closely approximate the classical continuity equation-based method for fluid flow. This closeness is theoretically justified by augmented Lagrangian method in a novel way. The convergence of Uzawa iterates is shown using a modified bounded constraint algorithm. The mathematical well-posedness is studied in a Hilbert space setting. Further, we observe a surprising connection to the Cauchy-Riemann operator that diagonalizes the system leading to a diffusive phenomenon involving the divergence and the curl of the flow. Several numerical experiments are performed and the results are shown on different datasets. Additionally, we demonstrate that a flow-driven refinement process involving the curl of the flow outperforms the classical physics-based optical flow method without any additional assumptions on the image data.
PERFORMANCE OF SMALL BUSINESSES: DOES SUSTAINABILITY REPORTING ISSUE MATTER?
Authors: Gozali Efva , Hamzah Ruth , Ferina Ika , Annisa Mutiara , Toruan Antonius
Published: May 2024

Sustainability reporting serves as a valuable tool to demonstrate how a business addresses economic and environmental challenges. This study investigates the influence of age, size and sustainability reporting comprehension of Micro, Small, and Medium-sized Enterprises (MSMEs) on their performance. From a certain population, 40 MSMEs were successfully collected as samples. Logistic regression was employed as the data analysis method. The results reveal that the age do not affect performance, meanwhile size positively affects performance. Moreover, it is found that sustainability reporting comprehension negatively affects performance of MSMEs. The results of this study contribute to bridge the literature gap in the scope of sustainability reporting for MSMEs. In addition, it offers support for the adoption of sustainability reporting standards for MSMEs as a specific sector.
ENHANCING TAX COMPLIANCE THROUGH DIGITAL TRANSFORMATION: EVIDENCE FROM CORPORATE TAXPAYERS' USAGE OF E-BUPOT
Authors: Faisol Moh. , Norsain Norsain
Published: May 2024

Digital transformation facilitates and accelerates taxpayers in withholding/collecting taxes and registering, reporting, and paying taxes. This research aims at understanding the use of E-Bupot in the tax withholding/collection process to improve tax compliance for corporate tax players in the Sumenep Regency. The authors used the phenomenology method by conducting interviews with two informants and then interpreting and explaining the actions or experiences of taxpayers. This research concluded that using information technology with E-Bupot was more practical in tax withholding. E-Bupot also sped up the tax collection process and minimized costs, including file storage because it did not use paper. The implication was that information technology could be an alternative to increase taxpayer compliance because technology had become a part of the lives of Indonesian people.
THE IMPLICATION OF PROFITABILITY AS A MODERATING IN THE RELATION OF ENVIRONMENTAL CERTIFICATION AND FINANCIAL PERFORMANCE TO MARKET REACTION
Authors: Widiatami Anna , Khasanah Nasriatun , Aeni Ida , Nurkhin Ahmad
Published: May 2024

This study aims to analyze and empirically evaluate the effect of financial and non-financial information submitted through annual reports on the market reaction, proxied by trading volume activity. A study was conducted in 103 manufacturing companies listed on the Indonesian Stock Exchange for the 2017-2021 period with 515 annual reports. The panel data moderating regression results show that environmental certification and financial performance, measured by Sales growth, market value added, and Tobin's Q Ratio, do not affect the market reaction. However, return on equity as a Profitability measurement can strengthen the relationship between environmental certification and sales growth in trading volume activity. This study implies that a high return on equity in companies attracts an investor more than environmental certification. Besides, it could change the confidence of the investor to invest in a company that has been obtaining ISO 14001 certificates.