bluuebunny/crossref_metadata_2025 huggingface dataset:
Limiting spectral distribution of stochastic block model
Authors: Su Giap Van , Chen May-Ru , Guo Mei-Hui , Huang Hao-Wei
Published: June 2023

The stochastic block model (SBM) is an extension of the Erdős–Rényi graph and has applications in numerous fields, such as data analysis, recovering community structure in graph data and social networks. In this paper, we consider the normal central SBM adjacency matrix with [Formula: see text] communities of arbitrary sizes. We derive an explicit formula for the limiting empirical spectral density function when the size of the matrix tends to infinity. We also obtain an upper bound for the operator norm of such random matrices by means of the Stieltjes transform and random matrix theory.
A lognormal/normal regime-switching commodity pricing model
Authors: Yuan Zhushun , Kwon Roy H.
Published: June 2023

Inspired by the negative price of WTI crude oil observed during the COVID-19 pandemic, we develop a new model for commodity pricing which allows structural change between price normality and lognormality under a Markov regime-switching (RS) framework. We augment the Extended Kalman Filter to calibrate the structural changing model. The model performance in calibration is compared to that of the common RS model with historical WTI spots, various futures and hypothetical scenarios. We conclude that our model is superior in capturing price dynamics especially in the oil market downturns. Encouragingly, the regime probabilities estimated with the new model indicate that during severe events including the 2008–2010 financial crisis, 2014–2016 oil crash and the outbreak of COVID-19 in 2020, WTI spot itself follows normal rather than the widely assumed lognormal process. This finding is consistent with our empirical studies. In addition, we assess the probability density of spot prices with the new model. Finally, we present the PDE finite difference and Monte Carlo approaches to price commodity options under the new model.
g
-C3N4–Co3O4 Z-Scheme Junction with Green-Synthesized ZnO Photocatalyst for Efficient Degradation of Methylene Blue in Aqueous Solution
Authors: Tamiru Mengistu Mintesinot , Wondimu Tadele Hunde , Andoshe Dinsefa Mensur , Kim Jung Yong , Zelekew Osman Ahmed , Hone Fekadu Gashaw , Tegene Newaymedhin Aberra , Gultom Noto Susanto , Jang Ho Won
Published: June 2023

A simple wet chemical ultrasonic-assisted synthesis method was employed to prepare visible light-driven g-C3N4-ZnO-Co3O4 (GZC) heterojunction photocatalysts. X-ray diffraction (XRD), scanning electromicroscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET), ultraviolet (UV), and electrochemical impedance spectroscopy (EIS) are used to characterize the prepared catalysts. XRD confirms the homogenous phase formation of g-C3N4, ZnO, and Co3O4, and the heterogeneous phase for the composites. The synthesized ZnO and Co3O4 by using cellulose as a template show a rod-like morphology. The specific surface area of the catalytic samples increases due to the cellulose template. The measurements of the energy band gap of a g-C3N4-ZnO-Co3O4 composite showed red-shifted optical absorption to the visible range. The photoluminescence (PL) intensity decreases due to the formation of heterojunction. The PL quenching and EIS result shows that the reduction of the recombination rate and interfacial resistance result in charge carrier kinetic improvement in the catalyst. The photocatalytic performance in the degradation of MB dye of the GZC-3 composite was about 8.2-, 3.3-, and 2.5-fold more than that of the g-C3N4, g-C3N4-ZnO, and g-C3N4-Co3O4 samples. The Mott–Schottky plots of the flat band edge position of g-C3N4, ZnO, Co3O4, and Z-scheme g-C3N4-ZnO-Co3O4 photocatalysts may be created. Based on the stability experiment, GZC-3 shows greater photocatalytic activity after four recycling cycles. As a result, the GZC composite is environmentally friendly and efficient photocatalyst and has the potential to consider in the treatment of dye-contaminated wastewater.
Plants and Plant‐Derived Molecules as Natural Immunomodulators
Authors: Zebeaman Meseret , Tadesse Mesfin Getachew , Bachheti Rakesh Kumar , Bachheti Archana , Gebeyhu Rahel , Chaubey Kundan Kumar
Published: June 2023

Background. Nowadays, the immunomodulatory properties of plants have been studied extensively with greater interest due to increasing awareness and combating the severity of immunomodulatory diseases. Scope and Approach. This paper highlights the efficacy of the available literature evidence on natural immunomodulators of plant origin and synthetic ones. In addition, several aspects of plants and their phytoconstituents responsible for immunomodulation have been discussed. Moreover, this review also discusses the mechanism involved in immunomodulation. Key Findings. One hundred fifty medicinal immunomodulatory plants are currently identified to find novel immunomodulatory drugs. Of these plants, the plant family Asteraceae also takes the first rank by offering 18 plant species (12%). Similarly of the plants studied so far, 40% belong to the Asteraceae family. Echinacea purpurea of this family is most known for its immunostimulating activity. The most prominent immune‐active bioactive molecules are polyphenols, terpenoids, and alkaloids. Also, eight plant bioactive immunomodulators were checked for clinical trials and found in the market. These are six immunosuppressants, resveratrol, epigallocatechin‐3‐gallate, quercetin, colchicine, capsaicin, and andrographolide, and two immunostimulants, curcumin and genistein. Nowadays, there are a lot of polyherbal traditional medicinal products sold in the market and claimed to their immunomodulators. However, much work is still needed to find more active immunomodulatory agents. The mechanism by which immunomodulatory medicinal plant exert their effect is through the induction of cytokines and phagocyte cells and the inhibition of iNOS, PGE, and COX‐2 synthesis.
The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: June 2023

As one of the most successful cancer therapeutic targets, estrogen receptor-α (ER/ESR1) has been extensively studied over the past few decades. Sequencing technological advances have enabled genome-wide analysis of ER action. However, comparison of individual studies is limited by different experimental designs, and few meta-analyses are available. Here, we established the EstroGene database through unified processing of data from 246 experiments including 136 transcriptomic, cistromic, and epigenetic datasets focusing on estradiol (E2)-triggered ER activation across 19 breast cancer cell lines. A user-friendly browser (https://estrogene.org/) was generated for multiomic data visualization involving gene inquiry under user-defined experimental conditions and statistical thresholds. Notably, annotation of metadata associated with public datasets revealed a considerable lack of experimental details. Comparison of independent RNA-seq or ER ChIP-seq data with the same design showed large variability and only strong effects could be consistently detected. Temporal estrogen response metasignatures were defined, and the association of E2 response rate with temporal transcriptional factors, chromatin accessibility, and heterogeneity of ER expression was evaluated. Unexpectedly, harmonizing 146 E2-induced transcriptomic datasets uncovered a subset of genes harboring bidirectional E2 regulation, which was linked to unique transcriptional factors and highly associated with immune surveillance in the clinical setting. Furthermore, the context dependent E2 response programs were characterized in MCF7 and T47D cell lines, the two most frequently used models in the EstroGene database. Collectively, the EstroGene database provides an informative and practical resource to the cancer research community to uniformly evaluate key reproducible features of ER regulomes and unravels modes of ER signaling.

Significance:

A resource database integrating 246 publicly available ER profiling datasets facilitates meta-analyses and identifies estrogen response temporal signatures, a bidirectional program, and model-specific biases.
Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance
Authors: Katona Bryson W. , Klute Kelsey , Brand Randall E. , Everett Jessica N. , Farrell James J. , Hawthorne Kieran , Kaul Vivek , Kupfer Sonia S. , Paiella Salvatore , Simeone Diane M. , Sussman Daniel A. , Zogopoulos George , Lucas Aimee L. , Kastrinos Fay ,   the PRECEDE Consortium, Bi Yan , Brentnall Teresa , Chung Daniel , Earl Julie , Gaddam Srinivas , Gallinger Steve , Graff John J. , Greenhalf William , Grossberg Aaron , Hart Philip , Idos Gregory , Jeter Joanne , Lindberg James , Lowy Andrew , Permuth Jennifer , Raitses-Gurevich Maria , Schrader Intan , Siveke Jens , Stoffel Elena , Vornhuelz Marlies , Wadlow Raymond
Published: June 2023

Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs enrolled between May 2020 and March 2022 were collected, with HRIs defined as participants enrolled in PRECEDE meeting guideline-based criteria for PDAC surveillance. Of 1,273 HRIs enrolled, 1,113 were eligible for inclusion, with 47.2% meeting familial pancreatic cancer criteria without a known pathogenic variant (PV) and the remainder having a pathogenic variant in a PDAC-risk gene (CDKN2A, STK11, PRSS1, BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, or EPCAM). Study participants were predominantly from the United States (82.7%), the most common age range at enrollment was 60–69 years (37.4%), and a non-PDAC cancer was present in 32.4%. There were racial/ethnic- and sex-based disparities among enrolled subjects, as the majority of participants were female (65.9%) and self-reported white (87.7%), with only 2.9% having Hispanic ethnicity. While more than 97% of participants consented to utilize imaging data and biosamples for research, there was no difference in rate of consent based on race/ethnicity, sex, or age, thereby demonstrating uniform participation in research activities among all subgroups after enrollment. Ensuring that diversity of HRIs in PDAC surveillance programs mirrors the communities served by participating centers is important. Substantial racial/ethnic- and sex-based disparities persist among recently enrolled HRIs undergoing PDAC surveillance, and therefore reducing these disparities will be a major focus of the PRECEDE Consortium moving forward.

Prevention Relevance:

Pancreatic cancer surveillance is critical to decreasing pancreatic cancer mortality; therefore, it is important that pancreatic cancer surveillance studies enroll diverse patients. We demonstrate that substantial racial/ethnic- and sex-based disparities exist amongst enrollment in the international PRECEDE consortium, highlighting the dire need for future efforts to reduce these disparities.

See related Spotlight, p. 305
Supplementary Table 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

Table showing the top 20 MYC gene targets with the highest positive charge density
Supplementary Methods 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

Supplementary methods
Supplementary Data 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

ZKN-157- chemical characterization
Figure S3 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

FACS analysis demonstrating ZKN-157 selectively induces cell cycle arrest and apoptosis
Figure S2 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

Results for pSILAC Mass Spec study demonstrating ZKN-157 inhibits translation of a subset of proteins
FIGURE 4 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

Sensitivity to ZKN-157 enriched in CMS2 subtype and is associated with a distinct molecular signature. A, Scatter plot displaying drug sensitivity metrics for ZKN-157 across 33 colorectal cancer cell lines with colors indicating sensitive, intermediate, and insensitive cell lines. Dotted lines indicate response percent (%) = 25 μmol/L (horizontal) and GI50 = 15 μmol/L (vertical). B, Heat map of gene expression data for CMS subtype genes across colorectal cancer cell lines shows an enrichment of sensitive cell lines in the CMS2 subtype. Row annotations show drug sensitivity, MSI/MSS status, CMS subtypes and average CNV ratios for Chr20q11–13. “+” used to annotate cell lines with WT TP53, unannotated cell lines harbor mutations in TP53. C, Bar graph plotting Chr20 CNV ratios for colorectal cancer cell lines, split by CMS2 subtype shows a further enrichment of sensitive cell lines in the CMS2 subtype with Chr20q11-13 CNV gain. D, Bar graph plotting IC50 values for ZKN-157 across colorectal cancer–derived CMS2 (light blue bars) and normal (black bar) organoids. Dotted line indicates IC50 = 30 μmol/L.
FIGURE 3 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

ZKN-157 treatment results in cell-cycle arrest in a sensitive colorectal cancer cell line. A, Immunoblots for p21 following 24-hour treatments with DMSO or ZKN-157 (40 μmol/L) are shown. Bar graphs show quantitated intensities normalized to B2M (loading control). B, Bar graph plotting percentage of SW1417 cells from cell-cycle phases.
FIGURE 1 from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

ZKN-157 selectively inhibits growth and protein translation in a sensitive colorectal cancer cell line. A, Chemical structure of ZKN-157. B, Percent response curves showing the effect of ZKN-157 treatment in COLO320DM and SW1417 cells. Curves are representative of three independent biological experiments. Error bars are SDs of two technical replicates. Table shows GI50 and LD50 values C, Cartoon showing the metabolic labeling assay workflow. D, Representative Western blot membranes of two independent biological experiments showing: -AHA (no AHA reagent added to lysate), CHX (positive control for translation inhibition), DMSO (negative control), and ZKN-157 treatment (40 μmol/L). Equal protein amount for all samples were used for click chemistry reaction. Samples resuspended in equal volume were loaded on gel. Intensity from densitometry of ZKN-157–treated samples was normalized to those of DMSO samples to calculate relative protein translation. Bar graph shows normalized values from two independent experiments. Error bars are SDs.
Data from A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: June 2023

Ribosomes in cancer cells accumulate numerous patient-specific structural and functional modifications that facilitate tumor progression by modifying protein translation. We have taken a unique synthetic chemistry approach to generate novel macrolides, Ribosome modulating agents (RMA), that are proposed to act distal to catalytic sites and exploit cancer ribosome heterogeneity. The RMA ZKN-157 shows two levels of selectivity: (i) selective translation inhibition of a subset of proteins enriched for components of the ribosome and protein translation machinery that are upregulated by MYC; and (ii) selective inhibition of proliferation of a subset of colorectal cancer cell lines. Mechanistically, the selective ribosome targeting in sensitive cells triggered cell-cycle arrest and apoptosis. Consequently, in colorectal cancer, sensitivity to ZKN-157 in cell lines and patient-derived organoids was restricted to the consensus molecular subtype 2 (CMS2) subtype that is distinguished by high MYC and WNT pathway activity. ZKN-157 showed efficacy as single agent and, the potency and efficacy of ZKN-157 synergized with clinically approved DNA-intercalating agents which have previously been shown to inhibit ribogenesis as well. ZKN-157 thus represents a new class of ribosome modulators that display cancer selectivity through specific ribosome inhibition in the CMS2 subtype of colorectal cancer potentially targeting MYC-driven addiction to high protein translation.
Significance:
This study demonstrates that ribosome heterogeneity in cancer can be exploited to develop selective ribogenesis inhibitors. The colorectal cancer CMS2 subtype, with a high unmet need for therapeutics, shows vulnerability to our novel selective ribosome modulator. The mechanism suggests that other cancer subtypes with high MYC activation could also be targeted.
Taxonomy of the genus Calamotropha Zeller (Lepidoptera: Crambidae: Crambinae) from China
Authors: KIM YONGNAM , QI MUJIE , WANG SHUXIA , LI HOUHUN
Published: June 2023

Thirty species of the genus Calamotropha Zeller, 1863 from China are reviewed. Five species are described as new: C. bleszynskii Kim & Li, sp. nov., C. duovirgata Kim & Li, sp. nov., C. nigerifera Kim & Li, sp. nov., C. parallela Kim & Li, sp. nov. and C. parvispina Kim & Li, sp. nov.; two species are newly recorded for China: C. alcesta Bleszynski, 1961 and C. punctivenella (Hampson, 1896). The female of C. sperlingi Li, 2019 is described for the first time. Calamotropha multicornuella Chen & Song, 2002 syn. nov. is synonymized with C. sienkiewiczi Bleszynski, 1961, and C. sawtoothella Chen & Song, 2002 syn. nov. is synonymized with C. latella (Snellen, 1890). Images of adults and genitalia of 28 known species with available specimens are provided, except images of genitalia provided by Li & Li in 2012. A key to the known Calamotropha species in China is included.
Hyperlocal Observations Reveal Persistent Extreme Urban Heat in Southeast Florida
Authors: Clement Amy , Troxler Tiffany , Keefe Oaklin , Arcodia Marybeth , Cruz Mayra , Hernandez Alyssa , Moanga Diana , Adefris Zelalem , Brown Natalia , Jacobson Susan
Published: June 2023

Cities around the world are experiencing the effects of climate change via increasing extreme heat worsened by urbanization. Within cities, there are disparities in extreme heat exposure that are apparent in various surface and remotely sensed observations, as well as in the health impacts. There are, however, large data gaps in our ability to quantify the heat experienced by people in their daily lives across urban areas. In this paper, we use hyperlocal observations to measure heat around Miami–Dade County, Florida. Temperature and humidity measurements were collected at sites throughout the county between 2018 and 2021 with low-cost sensors. By comparing these hyperlocal observations with a National Weather Service (NWS) site at the Miami International Airport (MIA), we show that maximum temperatures are on average 6°F (3.3°C) higher and maximum heat index values are 11°F (6.1°C) higher at sites in the county than at MIA. These measurements show that many sites frequently record a heat index above the local threshold value for heat advisory. This is in contrast with the fact that few forecast advisories are issued, and there are correspondingly few exceedances of the threshold at MIA. We use these results to motivate a discussion about the issues of this particular threshold for Miami–Dade County. We highlight the need for data that are closer to residents’ lived experience to assess the impacts of heat and help inform local and regional decision-making, particularly where heat exposure may be underappreciated as a potential public health hazard.
THE RED FLAG OF EMERGENCY USE AUTHORIZATION (EUA)
Authors: Kim HyunJung
Published: June 2023

The Emergency Use Authorization (EUA) policy, a representative biodefense policy, was legislated in the United States in 2001 based on lessons learned from Amerithrax, whereas Korea's EUA policy was based on lessons learned from the Middle East Respiratory Syndrome outbreak in 2015. Due to these divergent origins, the U.S. EUA's homeland security objectives were specialized to deal with highly pathogenic biological agents that could be exploited for bioterrorism, whereas the Korean EUA pursues disease containment purposes to strengthen mass‐testing practices. During the early phase of the COVID‐19 pandemic, the U.S. EUA revealed limitations in its integration with public health surveillance, laboratory partnerships, and insurance systems, which hampered the rapid expansion of testing capacities. Thereafter, once the limitations of the EUA were circumvented, the testing capacity of the United States began to catch up with that of South Korea, and later skyrocketed after solving these issues.
Women Directors and Board Dynamics: Qualitative Insights from the Boardroom
Authors: Wiersema Margarethe F. , Mors Marie Louise
Published: June 2023

Despite increasing attention to gender diversity on corporate boards, we have only limited understanding of what occurs within the boardroom when women are present. Prior empirical research has used various theories to infer how board gender diversity may influence firm outcomes, but without identifying the theoretical mechanisms underlying women directors’ influence on the board. To address this gap, we conducted interviews with women and men who have collectively served as directors with over 200 publicly listed companies in the United States and Europe. While prior research has suggested that the diverse cognitive perspectives women directors bring influence board decision-making, our study reveals novel insights as to the underlying mechanisms. Specifically, we contribute to the board gender diversity literature with the finding that women behave in ways contrary to existing board norms. By coming to board meetings highly prepared, being willing to acknowledge that they do not know something, asking questions, and getting things on the table, women impact the dialogue and interactions in the boardroom. Thus, our study sheds light on how the presence of women influences board dynamics, which has implications for corporate governance. Our findings also challenge prevailing gender theories as to how women are likely to behave, in that we do not find that women conform to gender stereotypes. Yet, we also find impediments to women directors’ ability to gain influence, in that men directors may not always acknowledge them or afford them respect as equal board members.
Parenting While Depressed: The Influence of Interpersonal Supports and Community Resources for Mothers
Authors: Dow-Fleisner Sarah , Baum Christopher , Pandey Shanta , Hawkins Summer Sherburne
Published: June 2023

Maternal depression may have a significant impact on multiple aspects of parenting throughout childhood, leading to negative outcomes for children. However, the impact of depression on parenting perceptions, practices, and involvement may differ among mothers, particularly when protective factors are present. Using data from the Fragile Families and Child Wellbeing Study, we compared three aspects of parenting (perceptions, practices, and involvement) between depressed and non-depressed mothers, and then investigated the influence of interpersonal supports and community resources on these aspects of the parenting, specifically for depressed mothers. Findings indicated that mothers with depression were equally involved with the child at home, but were more likely to hold negative perceptions of parenting. Furthermore, interpersonal supports and community resources had an indirect impact on parenting practices and involvement through perceptions of parenting, highlighting the importance of interventions for mothers with depression that address the appraisal and expectations of parenting stress and competencies.
Personal values and life domain satisfaction predict global life satisfaction differently across cultures
Authors: Galinha Iolanda Costa , Oishi Shigehiro , Pereira Cícero , Wirtz Derrick
Published: June 2023

The study tests two competing theoretical perspectives on the relationship between personal values and global life satisfaction, and the mediation of life domain satisfaction, contributing with novel empirical data across three countries and continents: United States ( N = 497), North America; Mozambique ( N = 544), Africa; and Portugal ( N = 541), Europe. Structural equation modelling showed that personal values and life domain satisfaction associated in both ways differently and similarly with global life satisfaction across countries. Global life satisfaction significantly associated with benevolence in the three samples; with stimulation in the U.S. and Mozambique, but not in Portugal; with tradition in Mozambique and Portugal, but not in the US; and with achievement only in Portugal. The two theoretical perspectives received partial support from the data, suggesting that each may explain part of the phenomena. Life domain satisfaction mediated the relationship between personal values and global life satisfaction. However, the person-environment congruency values perspective received the most support from the data, showing that personal values differ in how they predict global life satisfaction across samples. The differences found suggest a possible connection with individualism-collectivism and the developmental level in each country, but also with other dominant cultural values such as uncertainty avoidance and indulgence.
A case of metformin-associated lactic acidosis with cardiogenic and vasoplegic shock supported by ECPella
Authors: Ling Steven Kin-ho , Chung Kit Wang , Ma Hei Yee
Published: June 2023

Metfomin-associated lactic acidosis (MALA) is a rare but life-threatening complication of metformin use. We present a case of MALA with concurrent cardiogenic and vasoplegic shock which was successfully supported by ECPella (concurrent use of VA-ECMO and Impella). Early recognition, aggressive hemodynamic support with ECPella and early hemodialysis can be life-saving. Monitoring of both lactate and SvO2 trends can help understand the response to treatment.
Saphenous vein aneurysms characterization and treatment: A 36-year single center experience
Authors: Moreno Oscar , Kumar Kiran , Wakefield Thomas , Obi Andrea
Published: June 2023

Background

Superficial vein aneurysms (SVA) are rare vascular pathologies associated with trauma, chronic venous disease, and venous malformation.

Method

We retrospectively reviewed cases of SVA treated from 1986 to 2022.

Results

Out of 2463 venous procedures, 16 patients were found with 19 GSV and 1 SSV aneurysms, with 88% presenting with a palpable mass. Varicose veins were noted in 94% of patients, 81% had concomitant reflux, 15% had thrombus within the aneurysm sac, and 19% demonstrated multiple aneurysms. All patients underwent ligation and excision. Post-procedure, 55% of patients received anticoagulants, and 85% received compression. Mean follow-up was 19.4 months, with no aneurysm recurrence. We propose a modification to the current SVA classification.

Conclusion

The prevalence of multiple aneurysms suggests the need for complete limb imaging in affected patients. Surgical management of SVA was effective in preventing SVA recurrence, while the proposed classification modification will aid in future SVA management.
The power of fishing: The introduction of steam and motorization in Scandinavian fishing, 1880–1950
Authors: Hallén Per , Bornmalm Lennart , Alexandersson Henrik
Published: June 2023

The history of fishing has often been written from a local or regional perspective. There has gradually been a shift where fishing has been studied from a broader international perspective. Nevertheless, large international overviews need detailed studies of individual ports in a similar way as studies of individual ports benefit from the international perspective. The introduction of steam-powered fishing vessels in Scandinavia has often been regarded as an attempt to imitate fishing in Great Britain. However, a closer study of the Scandinavian countries shows that this does not match, for example, the Norwegian steam fishing fleet. Scandinavia's two main fishing ports with steam-powered fishing vessels, Ålesund in Norway and Gothenburg in Sweden, show great differences. Gothenburg is the place that has the most similarities with the large British fishing ports. Steam-powered fishing vessels played a modest role in Danish fishing. On the other hand, when it comes to the introduction of engines, the Danish fishery was the leader. However, it would take more than 30 years from the first functionable engines around the turn of the twentieth century before motor-driven fishing vessels could begin to compete with steam-powered fishing vessels. The problems of financing the new technology are emphasized in the article. Government loans were important in many countries, but much research is still needed to clarify the proportion that was government-financed and how much other financial actors contributed.
Corrosion characteristics of microwave and furnace annealed electroless Ni-P-TiO2 coatings
Authors: John PV George , Sahayaraj M Edwin , Jappes JT Winowlin , Leon S John
Published: June 2023

The Co-deposition of TiO2 particles (anatase type) of 200–300 nm with Ni-P electroless coatings on low carbon steel. The coated specimen was annealed by microwave and common electric furnace. The effects of microwave and furnace annealing temperatures on these coatings were characterized via. XRD, SEM, EDAX, and the corrosion performance was characterized through electrochemical polarization technique. The corrosion medium used for this work was sodium chloride (NaCl) solution and which contains 3.5 wt-% in distilled water. The result showed that, the microwave annealing method was enhanced the corrosion performance of the coating by diffused TiO2 particle into the matrix and reduced the micro voids presented in the matrix. Further, the corrosion mechanisms of the non-treated and the annealed coated materials have been explained in the consideration of crystallization, transformation of phases, grain size, and micro strain.
The epistemologies of research on the survival of consciousness after death in the golden era of the Society for Psychical Research (1882–1930)
Authors: Resende Pedro Henrique Costa de , Moreira-Almeida Alexander , Schubert Coelho Humberto
Published: June 2023

The Society for Psychical Research (SPR) of London was founded in 1882 with the purpose of investigating psychical phenomena, especially the theme of survival, with scientific rigour. Despite the recognized importance of the SPR for dynamic psychiatry in the nineteenth and twentieth centuries, there are few studies of its epistemological contributions to the theme of survival and its implications to science. In order to fill this gap, we have consulted the main journals of the SPR in its golden period, and highlight the epistemologies of Sidgwick, Myers, James, Podmore, Schiller, Lodge and Richet. We conclude that the authors, whether for or against survival, argued in defence of an expanded science, and looked forward to understanding the complexity of human experience.
3D digitization and archaeobotanical analysis of wooden artifacts
Authors: Caruso Fermé Laura , González Bagur Ivana
Published: June 2023

The study of wooden artifacts recovered in dry context is scarce. The objective of this work is to identify morphometric patterns in wooden artifacts and to evaluate their relationship with the technological manufacturing processes. To this end, wooden artifacts were analyzed from the site Cerro Casa de Piedra 7, through the 3D scanning, calculation of curvature directions and archaeobotanical analysis. These artifacts are associated to hunter-gatherer groups and different occupations of the early Holocene. The results obtained show, on the one hand, the efficiency of the use of these techniques in the analysis of wooden artifacts recovered in completely dry contexts. The use of 3D scanning techniques showed that they can improve the analysis of manufacturing traces and/or use of wooden artifacts and the possibility of simulating the obtained results by computer. On the other hand, they show the existence of morphometric patterns, sustained in time, which are related to the manufacturing of the artifacts from the Cerro Casa de Piedra 7. In summary, the archaeobotanical analysis methodology presented and developed in this work allows its application to the study of different woody materials regardless of their chronology and recovery site.
Statue of Dr. Aletta Henriëtte Jacobs (1854–1929): Physician, Activist, and an Inspiration
Authors: Bharadwaj Hareesha Rishab , Wellington Jack , Wellington Alexander
Published: June 2023

Dr Aletta Henriette Jacobs (9 February 1854 to 10 August 1929) was a Dutch physician and advocate of modern-day women's rights, being among the first female clinicians and to formally enrol at a Dutch university. She bolstered the Dutch and international women's movements and pioneered as the first woman to develop a clinic based on contraceptive principles in 1882 internationally. Her legacy has become paramount in the progression of modern-day feminism, where her vigour for equality and diversity has stipulated campaigns to demand women's voting rights, deregulate acts of prostitution, improve working conditions for women, and promote world peace through her work.
Book review: Kalpana Kannabiran, Law, Justice and Human Rights in India: Short Reflections
Authors: Uma Saumya
Published: June 2023

Kalpana Kannabiran, Law, Justice and Human Rights in India: Short Reflections (Orient BlackSwan, 2021), 416 pp., ₹1,500, ISBN 9789354421105 (Paperback).
Preliminary Screening of in vitro Kaempferia galanga Oil for Anti-Proliferative Activities Against HeLa and MCF-7 Cell
Authors: Panigrahi Rajashree , Parida Reena
Published: June 2023

Background

Kaempferia galanga, commonly known as aromatic ginger, is a potential herb with high medicinal value and is used to treat many diseases like diabetes and asthma. Cancer is a group of diseases characterized by abnormal cells that divide uncontrollably and spread throughout the body. Nowadays, medicinal plants are used for their essential oil activities, including anti-cancerous effects.

Objectives

The aim of this study is to establish a method for screening in vitro oil cytotoxic effects.

Materials and Methods

Murashige and Skoog (MS) medium with growth regulators like benzyladenine, kinetin, indole-3-acetic acid, adenine sulfate, and naphthalene acetic acid was used for plantlet production. The in vitro regenerated plants were studied for rhizome oil extraction using Clevenger’s apparatus and gas chromatography-mass spectrometry (GC-MS) analysis, followed by their cytotoxicity study against human cervical cancer cells (HeLa) and human breast cancer cells (MCF-7) by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction (MTT) assay.

Results

Upon analysis, it has been found that this medicinal plant contains ethyl-p-methoxycinnamate (EPMC) (56.41 ± 0.34%) as a vital compound in its rhizome oil. The validation of cytotoxicity in both cell lines was done by treatment with rhizome oil concentrations ranging from 6.25 to 100 µL, respectively. The IC50 value was found to be 44.18 ± 0.65 µL/mL in HeLa and 72.94 ± 0.26 µL/mL in MCF-7 cells after 24 h of incubation.

Conclusion

The results of this study would be helpful for this important medicinal plant to be used by pharmaceuticals in the treatment of cancer.
Fan responses to ownership change in the English Premier League: Motivated ignorance, social creativity and social competition at Newcastle United F.C.
Authors: Jones Ian , Adams Andrew , Mayoh Joanne
Published: June 2023

Over recent years there has been a significant increase in foreign ownership within the English Premier League, with ‘sportswashing’ being identified as a key motive for some new club owners. Whilst the effects of changes of ownership have received considerable focus, especially in terms of their impacts upon the club, less attention has been paid to the status of the owners themselves, how any perceived sportswashing strategy impacts upon fans, and how that impact is managed, especially in terms of the strategies that are used by fans to maintain a sense of identification. This paper focuses on the takeover of one Premier League football club, Newcastle United, and explores fan responses to its high-profile and controversial takeover by the Saudi Arabian Public Investment Fund (PIF). The paper explores the identity-maintenance strategies used by fans to maintain a positive association with the club using existing frameworks related to social creativity and social competition, as well as through the application of a novel strategy that has yet to be explored within the sport fan literature, that of motivated ignorance. The results demonstrate that whilst social creativity and social competition strategies are evident, motivated ignorance also provides an additional mechanism through which social identities may be protected from identity threat.
Therapeutic effect of C-type natriuretic peptide on persistent pain in a rat knee arthritis model
Authors: Hasegawa Shoichi , An Jae-Sung , Hino Jun , Amano Yusuke , Nakagawa Yusuke , Miyatake Kazumasa , Katagiri Hiroki , Nakamura Tomomasa , Sekiya Ichiro , Koga Hideyuki , Tsuji Kunikazu
Published: June 2023

Background

Intra-articular injection of C-type natriuretic peptide (CNP) at the acute inflammatory stage suppressed fibrotic changes in the infrapatellar fat pad (IFP), articular cartilage degeneration, and persistent pain in a monoiodoacetic acid (MIA)-induced rat knee arthritis model. In this study, we administered CNP during the inflammation subsiding period to evaluate CNP effectiveness in knees with osteoarthritis (OA) pathology.

Methods

20 male Wistar rats were randomly divided into two groups. The rats received an intra-articular injection of MIA solution in the right knee to induce inflammation-induced joint degeneration. One group subsequently received an intra-articular CNP injection for six consecutive days from day 8, whereas another group received vehicle solution. Pain avoidance behavior tests and histological analyses were conducted to examine the therapeutic effects of CNP.

Results

The incapacitance test indicated that the percent weight on the ipsilateral limb decreased after MIA injection by day 4 and continued to decrease until the end of the experiment in the vehicle group, suggesting persistent pain in the knee. Intra-articular injection of CNP reversed the weight-bearing ratio on day 19. Histological evaluation showed that the CNP group had more residual fat tissue in the IFP and fewer calcitonin gene-related peptide-positive nerve endings compared to the vehicle group. CNP could not reverse articular cartilage degeneration.

Conclusions

Intra-articular injection of CNP after the IFP fibrosis onset had no significant effect on OA severity and extent. Nevertheless, CNP might be utilized therapeutically for OA treatment since it can alleviate persistent knee pain and inhibit structural changes in residual fat tissue.
The Political Consequences of Racialized Ethnic Identities
Authors: Cardenas Kimberly , Silber Mohamed Heather , Michelson Melissa R.
Published: June 2023

Racial classifications are a social construct with no basis in biology; yet, race is an omnipresent and powerful factor in U.S. politics, shaping electoral boundaries, disbursement of resources, and political alliances (Omi and Winant 1994, Haney López 1994). Race, then, is a malleable construct wielded by varying interests, with racial definitions changing in response to social and political battles. Some new immigrant groups initially classified as not white have been reclassified as white over time, thereby benefitting from associated legal, economic, and sociopolitical privileges. More recently, however, some Latinos have sought recognition as a distinct non-white racial group, in acknowledgment of the racialization of their identities over time. We seek to better understand who is most likely to support a racialized Latino identity, and the political consequences of this choice. Using data from the 2020 Collaborative Multiracial Post-election Survey, we test whether individuals who believe that a Latino identity is a racial identity are also more likely to be interested in and engaged in politics. We also examine the extent to which support for a racialized Latino identity is associated with progressive attitudes on racial issues.
Experimental assessment and compressive constitutive model of rubberized concrete confined by steel tube
Authors: Zhou Zhi , Huang Wei , Wang Xiaodong
Published: June 2023

To investigate the confining effect and axial compressive behavior of rubberized concrete (RuC) confined by steel tube, axial compression tests were carried out on 12 circular RuC cylinders confined by steel tube. The cylinders considered parameters such as steel tube thicknesses (2 mm, 3 mm, 4 mm) and rubber volume replacement ratios of the fine aggregates (0%, 10%, 20%, and 30%). It was observed that the compressive strength of RuC decreases as the rubber volume replacement ratio increases. However, an increase in steel tube thickness enhances the confining effect of the core RuC, leading to an increase in its compressive strength and the corresponding strain, similar to that of conventional concrete. Moreover, post-peak curves are more likely to exhibit a strengthening part in confined concrete with more rubber content. Furthermore, a model was developed to determine the compressive strength of RuC confined by steel tube. Finally, an axial stress-strain model of steel tube confined RuC was proposed, which was validated against test results.
A Systematic Review of Interventions Addressing the Primary Prevention of Violence Against Women With Disability
Authors: Sutherland Georgina , Hargrave Jen , Krnjacki Lauren , Llewellyn Gwynnyth , Kavanagh Anne , Vaughan Cathy
Published: June 2023

Women with disability experience significantly more violence and abuse than their nondisabled peers. Efforts to implement, evaluate, and scale-up strategies to prevent violence against women are rapidly expanding, but we know less about “what works” to prevent violence against women with disability. While secondary and tertiary prevention aim to identify violence early and prevent further occurrence, this review focuses on primary prevention. In the disability services sector, primary prevention is sometimes referred to as safeguarding and covers a range of activities that aim to address the underlying determinants of violence to prevent it from happening in the first place. The aim of this review is to identify and synthesize research on evaluated interventions addressing the primary prevention of violence against women with disability and explore evidence about their quality and effectiveness. A systematic search across the bibliographic databases of Medline, CINAHL, Embase, and PsychInfo for peer-reviewed literature published in English on or after January 1, 2010, yielded 483 papers of potential interest. Twelve studies met the inclusion criteria and were considered for review. Data were extracted and the quality of the studies was assessed using the Quality Assessment Tool for Quantitative Studies. Most studies reported outcomes from pre- and post-test research designs and received a weak rating of quality. Although interventions targeting awareness, knowledge, and skill development showed evidence of effectiveness, there is a distinct lack of program development that draws on known risk factors for violence such as the intersection of ableism and gender inequality.
When the Stars Are Out: The Impact of Missed Games on NBA Television Audiences
Authors: Reilly Patrick , Solow John L. , von Allmen Peter
Published: June 2023

Using the 2018–2019 NBA season, we examine the causes and effects of star players missing games. Focusing on 19 star players, we find that injury, proximity to the end of season, games on consecutive days, and opponent quality lead to missed games. We then estimate a model of NBA television audience size using granular data from nationally broadcast games. Doubling the proportion of star players missing games reduces TV audience by approximately 6.5 million household viewings per regular season. A rough estimate of the advertising revenue lost due to stars missing games is between $15 and $20 million per season.