bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Effects of Long-COVID on Mental Health in the United States: A Population Based Study
Authors: Datta Anusua
Published: August 2024

Background
The term long-COVID is commonly used to refer to protracted symptoms following COVID-19 infection that persist beyond four weeks from onset. Long-COVID conditions have been associated with reduced quality of life. This study estimates the impact of long-COVID on anxiety and depression in the US, using survey data from nearly a million Americans.
Methods
The Household Pulse Survey, provides the first population based nationally representative data on the prevalence of long-COVID, starting with the survey’s June 2022 wave. A population-based survey allows us to conduct counterfactual research using control groups. Difference-in-differences models are applied to predict anxiety and depression in the population that contracted COVID-19 and had symptoms of long-COVID vis-à-vis control groups.
Results
Nearly 51.8% of those surveyed reported testing positive for COVID-19 and of these 27.3% reported suffering from long-COVID. Anxiety and depression rates were twice as high in those with long-COVID. Our sub-group analysis reveals that in general COVID-19 is associated with higher rates of anxiety and depression among younger adults and females, and those on the lower income and education scale. Whites, Blacks and Hispanics had higher odds of anxiety and depression symptoms compared to Asians in both the COVID-19 and long-COVID groups. Interestingly, long-COVID was associated with more negative mental health outcomes among males, where reported mortality rates were higher.
Conclusion
This study fills a significant gap in the literature on the mental health effects of long-COVID. Our results, based on a large population level data, point to a significant association between COVID-19, especially long-COVID, and cognitive impairment and mental health problems
Exploring the trends of Urban Scale and Urban Vitality on S&D Balance in the Yangtze River Delta, China from 2015 to 2025
Authors: Wang Ke , Chen Qiuxiao
Published: August 2024

Analysis of the spatiotemporal trends of urban scale and urban vitality on ecosystem services balance provides an essential basis for regional sustainable development. Based on multi-source big data, the actual levels of urban scale and urban vitality of Yangtze River Delta, China are constructed, solving the previous problem that statistical datasets cannot fully demonstrate the real-time and real scope of the scale and vitality. Moreover, the article develops an integrated quantitative and strategic research system including spatiotemporal correlation, predictive scenario simulation and importance-performance analysis. Results show that urban vitality increases ESs demand without hurting ESs supply, as seen by its favorable impact on the S&D ratio. On the other hand, because cities occupy resources and seize land, they reduce the availability of ESs. Second, the economic priority scenario had the greatest influence on the S&D ratio, reaching -37.5%. This resulted in Zhejiang Province's S&D value approaching 1 (the lowest S&D value being 2.044). In Anhui, Jiangsu Province, and Shanghai, the ecological priority scenario had the most impact on the S&D ratio, raising the S&D value to 0.58~1.057. Third, although urban scale and ecological priority scenarios balance S&D by enhancing ESs supply in northeastern YRD, urban vitality and economic priority scenarios complement each other by improving ESs demand in southwest YRD.
It is safe to use the ulnar length difference to correct the radial length difference in the 3D-planning process of a radius osteotomy in patients with a distal radius malunion
Authors: Smees Camiel J , Nijhuis Koen D Oude , Heide Stein van der , Heuvel Judith olde , Doornberg Job N , Vochteloo Anne J H , Tuijthof Gabriëlle J M
Published: August 2024

Background
A corrective radius osteotomy is often performed in patients with a symptomatic distal radius malunion. In 3D-planned osteotomies, the unaffected radius is mirrored over the malunited radius after adjusting for left-right length differences using both ulnae. This approach assumes that ulnar length differences in a malunion population are similar to those in a healthy population. This study was conducted to analyze the difference in ulnar length in a distal radius malunion population and to assess the potential influence of age, sex, or malunion side on this difference.
Methods
We evaluated 65 adult patients with distal radius malunion using bilateral forearm CT scans. 3D models of both ulnae were constructed, and length differences were determined along a standardized length axis. The results were compared to two populations without a radius malunion.
Results
The average absolute ulnar length difference was 2.57 mm (SD 1.81), which was comparable to the two healthy populations. This difference was not significantly affected by age, sex, or malunion side.
Conclusion
This study demonstrated that using the ulnar length difference to correct for radial length difference in the current 3D planning process, before using the contralateral radius as a template for a corrective osteotomy in patients with radius malunion, is safe.
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Authors: Zhao Juanjuan , Chen Manling , Li Xudong , Chen Zhaoqi , Li Wei , Guo Rongqun , Wang Min , Jiang Zhongxing , Song Yongping , Wang Jianxiang , Liu Delong
Published: August 2024

Background Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered chimeric Fcγ receptor (FcγR) T cells and tested their potential as a versatile platform for universal T cell therapy.
Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs).
Results Three types of CFR T cells were engineered, 16s3, 32-8a, 64-8a CFR T cells. In the presence of rituximab (RTX), cytotoxicity of all three types of CFR T cells against CD20+ Raji-wt, K562-CD20+, and primary tumor cells was significantly higher than that of the mock T cells (P < 0.001). When herceptin was used, all three types of CFR T cells exhibited significant cytotoxicity against HER2+ cell lines of SK-BR-3, SK-OV-3, and HCC1954 (P < 0.001). The cytotoxicity of 64-8a CFR T cells was significantly inhibited by free human IgG at a physiological dose (P < 0.001), which was not observed in 16s3, 32-8a CFR T cells. Compared to 32-8a CFR T cells, 16s3 CFR T cells exhibited more prolonged cytotoxicity than 32-8a CFR T cells (P < 0.01).
In in vivo assays using xenograft models, 16s3 CFR T cells significantly prolonged the survival of mice xenografted with Raji-wt cells in the presence of RTX (P < 0.001), and effectively reduced tumor burden in mice xenografted with SK-OV-3 cells in the presence of herceptin (P < 0.05). No significant non-specific cytotoxicity of CFR T cells was found in vivo.
Conclusion The anti-tumor effects of the CFR T cells in vitro and in xenograft mouse models are mediated by specific MoAbs such as RTX and herceptin. The CFR T cells therefore have the features of universal T cells with specificity directed by MoAbs. 16s3 CFR T cells are chosen for clinical trials.
A GFP-GAN based method for improving clarity of license plate images
Authors: Huang Tianyun , Wei Jinxu
Published: August 2024

License plate recognition is a very important component of intelligent transportation system, and its accuracy and speed affect the operation of the entire system. However, it is still difficult to achieve high accuracy in license plate positioning and character recognition for low-quality license plate images. To migrate the GFP-GAN model from blind face reconstruction to license plate image restoration, we made contributions to improve the clarity of license plate images in three aspects: (1). add motion blur present commonly on license plate images rather than facial images; (2). add the license plate recognition loss during training to increase the network's ability to recover correct characters; (3). align the region discriminator to the license plate position to optimize the region recovery effect. As in GFP-GAN, the multi-scale semantic information of low-quality license plate image is extracted by U-Net (extractor), and converted to coding that controls the image content (encoder), then the coding is input to a pre-trained StyleGAN2 network to generate the corresponding high quality license plate image (generator/decoder). The migrated model, datasets requirement and preparation, training process and algorithms are given in detail. As compared with existing methods, the experiments show that our method can significantly improve the accuracy on license plate recognition, with advantages of strong adaptability to various type of blurs, fine and smooth restoration quality, prominent emphasis on license plate area.
The complex kinematics of the young stars orbiting the SMBH in the Galactic center can be explained by an intermediate-mass companion of Sgr A★
Authors: Wang Long , Zheng Xiaochen , Lin Douglas , Burkert Andreas , Mao Shude
Published: August 2024

The inner parsec of the supermassive black hole (SMBH) in the center of the Milky Way, Sgr A★, contains a cluster of several hundred young, massive stars. Their complex, highly structured kinematics poses an intriguing conundrum on their origin within the strong tidal field close to the SMBH. It has been suggested that the encounter of a gas cloud with the SMBH could produce a fast rotating disk of coeval, massive stars. This result however differs strongly from the observed multi-component orbital distribution. We demonstrate that star-star scattering within the disk can only weakly change their orbits and cannot explain the observations, even if one includes the dispersal of an additional gaseous disk component. Including however the gravitational interaction with a putative intermediate-mass companion (IMC) of Sgr A$^\star$, possibly an intermediate mass black hole, naturally scatters the stars into their current kinematic configuration on timescales consistent with their stellar ages.
Impact of Genetic Ancestry on T-cell Acute Lymphoblastic Leukemia Outcomes
Authors: Teachey David , Newman Haley , Lee Shawn , Pölönen Petri , Shraim Rawan , Li Yimei , Liu Hongyan , Aplenc Richard , Bandyopadhyay Shovik , Chen Changya , Chen Zhiguo , Devidas Meenakshi , Diorio Caroline , Dunsmore Kimberly , Elghawy Omar , Elhachimi Amira , Fuller Tori , Gupta Sumit , Hall Junior , Hughes Andrew , Hunger Stephen , Loh Mignon , Martinez Zachary , McCoy Michael , Mullen Cassidy , Pounds Stanley , Raetz Elizabeth , Ryan Theresa , Seffernick Anna , Shi Gongping , Sussman Jonathan , Tan Kai , Uppuluri Lahari , Vincent Tiffaney L , Wang'ondu Ruth , Winestone Lena , Winter Stuart , Wood Brent , Wu Gang , Xu Jason , Yang Wenjian , Mullighan Charles , Yang Jun , Bona Kira
Published: August 2024

The influence of genetic ancestry on biology, survival outcomes, and risk stratification in T-cell Acute Lymphoblastic Leukemia (T-ALL) has not been explored. Genetic ancestry was genomically-derived from DNA-based single nucleotide polymorphisms in children and young adults with T-ALL treated on Children’s Oncology Group trial AALL0434. We determined associations of genetic ancestry, leukemia genomics and survival outcomes; co-primary outcomes were genomic subtype, pathway alteration, overall survival (OS), and event-free survival (EFS). Among 1309 patients, T-ALL molecular subtypes varied significantly by genetic ancestry, including increased frequency of genomically defined ETP-like, MLLT10, and BCL11B-activated subtypes in patients of African ancestry. In multivariable Cox models adjusting for high-risk subtype and pathways, patients of Admixed American ancestry had superior 5-year EFS/OS compared with European; EFS/OS for patients of African and European ancestry were similar. The prognostic value of five commonly altered T-ALL genes varied by ancestry – including NOTCH1, which was associated with superior OS for patients of European and Admixed American ancestry but non-prognostic among patients of African ancestry. Furthermore, a published five-gene risk classifier accurately risk stratified patients of European ancestry, but misclassified patients of African ancestry. We developed a penalized Cox model which successfully risk stratified patients across ancestries. Overall, 80% of patients had a genomic alteration in at least one gene with differential prognostic impact by genetic ancestry. T-ALL genomics and prognostic associations of genomic alterations vary by genetic ancestry. These data demonstrate the importance of incorporating genetic ancestry into analyses of tumor biology for risk classification algorithms.
Sequential Plasmodium Infections in Two Resident Families in Mangalore, India
Authors: MUKHI BENUDHAR
Published: August 2024

Eleven members of two resident families in Mangalore city suffered from Plasmodium falciparum, P. vivax and mixed infections of both parasites in a sequential manner despite using bed nets regularly. Malarial symptoms of febrile illness started with chills and rigors at the schools for children and at work places for adult members. Five members of first family are from the central part of the city, and six members in the second family reside ∼10 km away from the central city, their live locations as well as community health care (CHC) center were mapped using QGIS software, respectively. Interestingly, first infection started with P. falciparum followed by P. vivax in the first family. However, P. vivax appeared first in the second family followed by mixed infection, and the last infection was P. falciparum. Both the families reside in close proximities of construction sites, which correlate with the role of mosquito breeding sites and indoor biting in ongoing malaria transmission in the city.
Graduação em Odontologia e a Aplicação do PBL (Problem-Based Learning): suas Prinicpais Implicações
Authors: Carregosa Fernando José Santana , Dantas Janaína Araújo , Gaujac Danielle Pereira , Gaujac Cristiano
Published: August 2024

As novas Diretrizes Curriculares Nacionais (DCN) preconizam realinhamento dos métodos de ensino utilizados nos currículos de graduação em odontologia. O PBL (Problem Based Learning) é exemplo de abordagem ativa amplamente utilizada em cursos da área da saúde. Caracteriza-se pelo foco no aluno, exige atitude proativa e crítica, possibilita o desenvolvimento de habilidades de integração entre teoria e prática. Os alunos vivenciam situações problemáticas, refletem sobre suas possíveis causas, buscam informações sintéticas na literatura científica, formulam hipóteses e dicutem possiveis diagnósticos e formas de intervenção. O objetivo desta revisão da literatura é fornecer informações sobre utilização de métodos PBL na graduação de Odontologia. Após uma busca sistemática de artigos científicos na base de dados da Biblioteca Virtual de Saúde, foram selecioados e analisados criteriosamente 10 artigos publicados nos últimos 10 anos relatando a aplicação desse método na formação de cirurgiões-dentistas. Dos resultados obtidos mostrou que a aplicação do método PBL, no currículo odontológico, estimula os alunos de serem capazes de encontrar soluções para os mais diversos e complexos casos clínicos de forma autônoma e eficiente. Conforme os resultados, é evidenciado que o uso do PBL possibilitou a formação de um perfil profissional diferenciado e que atendem as mais recentes diretrizes curriculares do curso de Odontologia.
AVANT PIED FLOTTANT : UNE LESION RARE
Authors: Aznague Youness , Chaoui Abdenasser
Published: August 2024

Lavant pied flottant est une lesion rare et complexe rentrant dans le cadre des traumatismes haute energie du pied. Cette blessure est typiquementcaracterisee par des luxations concomitantes des deux extremites articulaires des metatarsiens luxation bipolaire . Nous rapportons le cas dun patient presentant de multiples luxations bipolaires de metatarsiens.Le caractÃ¨re particulier de ces lesions emane de sa rarete (seulement quelques cas ont ete rapportes dans la litterature avec atteinte dun rayon ou deux) et du caractÃ¨re pejoratif des lesions negliges des metatarsophalangienne en presence dune lesion de linterligne de Lisfranc.
LUXATION BILATERALE DE LA HANCHE: CAS RARE
Authors: Aznague Youness
Published: August 2024

Hip dislocation is a permanent displacement of the femoralheadoutside the acetabulum. Due to the increasingnumber of road accidents, thispathologyisexperiencing an increase in its incidence.Standard radiographyremains essential for diagnostic confirmation.Computedtomographyremainsreserved in most cases for the search for associatedlesions. Emergency management isnecessary to avoidirreversiblesequelae, includingnecrosis of the femoralhead.
EFFICACY OF DEXAMETHASONE AS AN ADJUVANT TOBUPIVACAINE IN SUPRA CLAVICULAR BRACHIAL PLEXUS BLOCK:A COMPARATIVE STUDY
Authors:   MBBS, (MD)., Sandeep CH. , Sahithi Priya G. ,   MBBS, (MD)., Chenna Kesava Swamy K. ,   MBBS, MD., Associate Professor.
Published: August 2024

Aim:To compare the efficacy of Dexamethasone when combined with Bupivacaine to Bupivacaine alone in terms of their analgesic efficacy and onset time of sensory and motor blockades for procedures involving the upper limb in Supraclavicular Brachial Plexus Block. Introduction: The rise in pain therapy, the superiority of regional anaesthesia in urgent procedures, and the growing significance of outpatient surgery in anaesthesiology require a specialised focus on peripheral nerve blocks. In the case of upper limb procedures, the elected choice during regional anaesthesia is the blocking of the supraclavicular brachial plexus. Materials and methods: It is a randomised controlled trial the study was undertaken in patients posted for elective and emergency upper limb surgeries. 100 patients aged 20 to 60 years with ASA classes 1 and 2.The participants were assigned to two groups by a random process. Group A â€“Was given Bupivacaine alone. Group B â€“ Was given Bupivacaine along with Dexamethasone. Results: Group B patients had a prolonged duration of analgesia and premature initiation of both sensory and motor paralysis. Discussion: The addition of Dexamethasone 8mg along with 0.5% Bupivacaine in the Supra clavicular brachial plexus block extends the length of pain relief and provides the premature beginningof both sensory and motor blockades, reducing the requirement of rescue pain relievers. Conclusion: The addition of Dexamethasone 8mg along with 0.5% Bupivacaine in Supra clavicular brachial plexus block provides early onset time of both sensory and motor blockades and prolongs the duration of analgesia.
ZAPPED: RADIOLOGY IN PEDIATRIC DENTISTRY
Authors: Baviskar Mansi , S. Naik Shilpa , Sharma Rachna , Lakhotiya Rutuja , Namapalle Apurva
Published: August 2024

Radiographs are an integral part of in a Pediatric Dental practice. Their use in diagnosis and treatment planning cannot be refuted. There are various radiographs available for this purpose -IOPA (conventional and RVG),Orthopantogram (OPG ) and latest being Cone Â–beam computed tomography (CBCT ) with their advantages and disadvantages .Every time radiograph is taken, child is exposed to radiation Children are more sensitive to the X-rays as compared to adult. The knowledge of the exposure time ,effective radiation dose of various radiographs in children help us to make an informed decision on their use .The type and number of x-rays taken in children need to be limited and justified. Ill effect of radiation on sensitive developing cells of a child has dangerous and long term effects which need to be taken into consideration. while selecting the radiograph to be taken.
PREVALENCE AND RISK FACTORS ASSOCIATED WITH MULTI-DRUG RESISTANT ORGANISMS IN ADULT INTENSIVE CARE UNIT OF KFSH, TABUK, SAUDI ARABIA, 2023
Authors: Fraih Al Enzi Eman , Hassan Saleh Lama , Abdelwhed Mohammed Ahmed Swsan
Published: August 2024

Purpose:Toassess the prevalence and risk factors associated with multi-drug resistant organisms in adult intensive care unit of KFSH-Tabuk during the year 2023. Methods:This study was a retrospective, descriptive, cross-sectional institutionalâ€“based studyincluding88 cases of ICU patientswith positive microbiology cultures for MDROs between the 1st of January 2023 to 31st of Dec 2023 in King Fahad Specialist Hospital, Tabuk, Saudi Arabia. Results:The prevalence of MDRO among ICU patients was found to be 31.4%. Males (64.8%) were more than females (35.2%). The most common age group was found to be 66-80 years (29.5%), followed by more than 80 years (22.7%). The majority of patients (64.8%) has chronic diseases, and the most common chronic disease was hypertension (63.2%), followed by diabetes mellitus (56.1%). (93.2%) of patients had external medical support equipment. Of them, the majority (52.3%) had three external medical support equipment, followed by two (20.5%), and the most common external medical support equipment was found to be foley catheter (F.C) (81.7%), followed by central venous line (CVL) (64.6%), then endotracheal tubes (ETT) (50%). (56.8%) of patients had community-onset (CO) MDRO, while (42%) had healthcare facility-onset (HO) MDRO. Carbapenem-resistant Enterobacterales (CRE) MDR (33%) was the most common type of MDRO, followed by Acinetobacter MDR (28.4%). The majority of the identified organisms (87.5%) were gram-negative bacteria. The most common type of organism was Klebsiella pneumonia (37.5%), followed by Acinetobacter baumannii (29.5%), then Escherichia coli (10.2%). Sputum sample (42%) was the most common type of taking the sample. The majority of patients (87.5%) had only one type of organism, while (9.1%) had two types of organisms. Conclusion: This study can conclude that the prevalence of multi-drug resistant organisms in adult intensive care unit of KFSH-Tabuk during 2023is not that high. However, risk factors should be taken into consideration in order to prevent them, and thus, decrease the incidence of multi-drug resistant organisms and decrease the mortality.
EVALUATION OF ANTIDIABETIC ACTIVITY OF BILE FROM GALLUS GALLUSDOMESTICUS
Authors:   Department of Pharmacology College of Pharmaceutical Sciences, Government Medical College Kannur, Kerala-670503., B.K. Athira , M. Minil ,   Asst. Professor Dept. of Pharmacology College of Pharmaceutical Sciences, Government Medical College Kannur, Kerala-670503.
Published: August 2024

Diabetes mellitus is a chronic condition characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The current study aimed at evaluating the antidiabetic activity of bile from Gallus gallusdomesticus. The zoochemical analysis revealed the presence of steroids. The invitro antioxidant activity of the HMEB and in vitroantiinflammatory activity of HMEB was evaluated. The invitroantidiabetic activity was investigated by Î±-Amylase inhibition assay, and glucose uptake assay. The gene expression study was carried out for GLUT-4 and PPAR-ê© was compared with the housekeeping gene Î²-actin. The animal toxicity study was performed as per OECD test guidelines 423 limit test The OGTT was conducted in normal rats and observed significant blood glucose lowering with HMEB (high dose). Thus hydro-methanolic extract of bile from Gallus gallusdomesticus could be developed as a potential drug candidate for the treatment of diabetes mellitus.
A STUDY TO ASSESS THE EFFECTIVENESS OF SELF-INSTRUCTIONAL MODULE ON PREVENTION OF CERVICAL R.R. NURSING COLLEGE BENGALURU KARNATAKA
Authors: K.M Chithra , J. Pavithra , . Karthikeyaprasath
Published: August 2024

The objectives of the study: 1. To assess the knowledge of women on prevention of cervical cancer. 2. To evaluate the effectiveness of structured teaching programme on prevention of cervical cancer. 3. To analyze the knowledge of women on prevention of cervical cancer with selected variables. The study was conducted at Nursing institutes, Bengaluru. The population for the study was aged between 35 â€“ 55 years. The size of the sample was forty. The sample was selected through the purposive sampling technique. A structured interview schedule was used to collect the required information regarding prevention of cervical cancer. The tool was given for content validity to the experts in the field of nursing and Obstetrics and gynecology. A pilot Study was conducted on 5 samples in Soldevanahalli, Bengaluru from 1ST April to 3rd April 2023 and found that the tool was feasible and appropriate. The reliability of the tool was tested by spearmans brown formula and Guttmann split of method and obtained value r= 0.892 revealed that the tool was reliable. The data was collected from 12th April 2023 to 3rd May 2023 at Acharya institutes, Bengaluru. In view of the nature of the problem selected and objectives to be accomplished pre-experimental one group pretest and posttest design was considered most suitable for the study to evaluate the effectiveness of structured teaching programme on prevention of cervical cancer. The analysis and interpretation of data was done with the help of descriptive and inferential statistics. The result of the major findings indicated that women had inadequate knowledge in various aspects in prevention of cervical cancer. Structured teaching programme was found to be very effective method of providing information regarding prevention of cervical cancer. The mean post test knowledge is significantly higher than the mean pre test knowledge scorest=16.250 p<0.000 level. Modified gain knowledge scores shows maximum gain in causes, signs and symptoms and prevention of cervical cancer. The study conducted that the structured teaching programme on various aspects in prevention of cervical cancer was an effective method for providing moderate to adequate knowledge and helps women to prevent cervical cancer and enable them to live a better quality of life. On the basis offindings, it is recommended that a similar study may be replicated using a larger number of respondents. It is also recommended that other methods of teaching along with frequent reinforcement may be implemented for improving the knowledge on prevention of cervical cancer. Objectives 1. To assess the knowledge of women on prevention of cervical cancer. 2. To evaluate the effectiveness of structured teaching programme on prevention of cervical cancer. 3. To analyze the knowledge of women on prevention of cervical cancer with selected variables.
RISK OF SUBSEQUENT HIP FRACTURES AND MORTALITY FOLLOWING LOW VELOCITY TRAUMA IN THE ELDERLY POPULATION
Authors: Singh Shantanu
Published: August 2024

This study investigates the risk of subsequent hip fractures and mortality following low-velocity trauma in elderly populations. Conducted over 18 months at Tertiary Care Institute of Central India, the study included 100 patients aged over 60 years who had experienced hip fractures due to low-velocity trauma. Data were collected, analyzed, and statistically evaluated. The study aimed to identify the correlation between initial fractures and the risk of subsequent fractures and mortality within a year.
MEDICINAL PLANTS EXHIBIT VARIATION IN LEAF MORPHOLOGY FROM FLORA OF TELANGANA, INDIA
Authors:   Plant Systematics, Biodiversity and Conservation Laboratory, Department of Botany, University College of Science, Saifabad, Osmania University, Hyderabad -500 004, Telangana State, India., Dudagonda Ashok , Ramana Munigela Venkat ,   Plant Systematics, Biodiversity and Conservation Laboratory, Department of Botany, University College of Science, Saifabad, Osmania University, Hyderabad -500 004, Telangana State, India., Kante Nethaji ,   Plant Systematics, Biodiversity and Conservation Laboratory, Department of Botany, University College of Science, Saifabad, Osmania University, Hyderabad -500 004, Telangana State, India.
Published: August 2024

Intraspecific variation in medicinal plants known from since ancient times from India region. Many of the medicinal plants belong to flowering plants expressing the variations at different levels in a isolated populations or in a single individual. Particularly the medicinal plants exhibit variation is leads to the much confusion in the local and indigenous systems of medicines. Investigation and identification of intraspecific medicinal plants from flora of Telangana region and its causes and consequences in the local and traditional medicines are discussed in detail in the present paper.
Repeated ischemic stroke and its prevention
Authors: Pizova N. V. , Pizov A. V.
Published: August 2024

Stroke is the world’s 2nd – 3rd leading cause of death and mortality. The risk of stroke is much greater for survivors of stroke. Survivors of a transient ischemic attack (TIA) or ischemic stroke are at higher risk of recurrent stroke during the interval between a few days or weeks and several years after the first event. Risk factors for ischemic stroke include hypertension, diabetes, hyperlipidemia, etc. The highest rate of recurrent stroke is observed in large artery atherosclerosis (atherothrombotic stroke) and cardioembolic stroke, while a recurrent stroke most often relates to the same subtype. A lacunar stroke is noted to have a lower recurrence rate, and a recurrent stroke may have a subtype that is different from the first one. In a recurrent stroke, neurological damage is usually more severe and harder to deal with. Patients with recurrent stroke have a higher mortality rate compared with patients with the first stroke. Secondary prevention is crucial to reduce recurrent ischemic stroke rates. To identify CVD risk factors is the initial priority when focusing efforts on secondary prevention. Lifestyle modifications, including tobacco cessation, decreased alcohol use, and increased physical activity, are also important in the management of patients with a history of stroke or transient ischemic attack. Optimal pharmacotherapeutic preventive strategies should be tailored to the specific stroke subtype. Antiplatelet therapy is recommended to reduce the risk of recurrent ischemic stroke, and its choice should be based on treatment duration, safety, efficacy, the cost of the drug, and patient characteristics and preferences.
Piriformis muscle pain syndrome: the myths and reality
Authors: Akhmedzhanova L. T. , Isaikin A. I. , Vakhnina N. V. , Busol V. N. , Bashkatova M. M. , Efimova E. T. , Upatova A. G.
Published: August 2024

Issues of diagnosis, effective treatment and prevention of chronic pain syndromes represent an urgent problem of modern medicine. About 80% of the population has experienced low back pain (LBP) at least once in their life; in 20% of patients acute LBP becomes chronic. Pain in the gluteal region with radiation to the leg can be caused by damage to various structures (joints, ligaments, deep muscles of the gluteal region, spinal roots), which are closely located and have similar innervation. The article presents a clinical case that illustrates the difficulties of diagnosing deep pain syndrome in the gluteal region in a young athlete. The condition, which was initially considered as myofascial pain syndrome of the piriformis muscle, upon detailed examination and observation turned out to be a rheumatological pathology (Bechterew’s disease). The article discusses the etiology, diagnostic criteria, differential diagnosis and treatment of piriformis muscle syndrome. There are currently no reliable diagnostic tests or validated diagnostic criteria to confirm the diagnosis, and therefore piriformis syndrome should be considered a diagnosis of exclusion. In clinical practice, there is both overdiagnosis of piriformis muscle syndrome with the widespread use of various invasive procedures, and ignorance of this syndrome. In most cases, secondary piriformis syndrome is observed and identification of the causative factor is decisive for the successful treatment of patients. Treatment of piriformis muscle syndrome should include the elimination of provoking factors, kinesiotherapy, NSAIDs, muscle relaxants, and, if indicated, therapeutic blockades, and for chronic pain syndrome, cognitive behavioral therapy and antidepressants. Nimesulide is a NSAID with proven effectiveness and a good safety profile, and therefore can be recommended for the treatment of both musculoskeletal pathologies and symptomatic treatment of rheumatological diseases.
Pain and sensory disorders after removal of mandibular third molars
Authors: Maximova M. Yu. , Suanova E. T.
Published: August 2024

Introduction. Extraction of mandibular third molars is one of the most common oral surgical procedures.

Aim. To evaluate the efficacy of B Complex Preparation on pain and sensory problems related to inferior alveolar nerve damage after surgical removal of mandibular third molars.

Materials and methods. In the open-label comparative trial 86 patients aged 45 to 54 years with sensory disturbances, lasting 72 hours, after surgical removal of mandibular third molar were included. Pain intensity was assessed using a visual analogue scale (VAS). Quantitative sensory testing (QST) was performed with the computer-controlled Thermal Sensory Analyzer (TSA type II, Medoc Ltd., Ramat Yishai, Israel) with contact thermode (30 × 30 mm). Patients with inferior alveolar nerve damage were divided into 2 groups: the first group – 44 patients received the standart therapy in combination with B Complex Preparation for 30 days, in the second group 42 patients received the standart treatment.

Results. After a course of treatment in the first group (B Complex Preparation) was determined the relieving of numbness and pain in 90.9% of patients with inferior alveolar nerve damage. The pain intensity in VAS reduced from 6.3 ± 0.9 to 0.8 ± 0.2 points (p = 0.02) in the first group and from 6.1 ± 0.6 to 4.8 ± 0.4 points (p = 0.09) in the second group. Only in the first group there was a decrease of the warm sensation threshold during QST, which additionally confirms the positive therapeutic effect of B Complex Preparation.

Conclusion. Effectiveness of therapy with B Complex Preparation was noted in patients with algic manifistations and sensory disorders after the removal of the third molar.
Currículo e avaliação da aprendizagem no projeto Escola Cidadã
Authors: Benvenutti Dilva Bertoldi , Paulo Fernanda dos Santos
Published: August 2024

Este artigo explora a Escola Cidadã de Porto Alegre, um projeto educacional progressista implementado nos anos 90 como resposta às políticas neoliberais. O objetivo geral é analisar os conceitos de currículo e avaliação da aprendizagem sob a perspectiva de Paulo Freire, focando na transformação social e democratização do ensino. A metodologia envolve uma revisão documental e bibliográfica, destacando a participação comunitária e a gestão democrática como pilares do projeto. Os resultados indicam que o currículo da Escola Cidadã é dinâmico, integrando saberes culturais e locais, e a avaliação é processual e contínua, focada no desenvolvimento do aluno. As reflexões apontam para o impacto transformador de um modelo educacional que promove cidadania ativa e formação crítica. Em conclusão, apesar dos desafios estruturais e políticos, a Escola Cidadã oferece uma referência viável para uma educação inclusiva e transformadora, reafirmando a educação como um campo de resistência e emancipação social.
Kheiron: Uma aplicação web para acompanhamento pedagógico focado em treinamentos de programação competitiva
Authors: De Oliveira Lucas Santana , Bezerra Filho Alexandre Douglas Leite , Vasconcelos Rafael Oliveira
Published: August 2024

A programação competitiva é um esporte mental em que os competidores resolvem problemas de Ciência da Computação dentro de um tempo limitado, sem acesso a materiais externos. Ganhou popularidade nas instituições de ensino fundamental e médio com o crescimento da internet e das competições como a Olimpíada Brasileira de Informática e a Maratona Brasileira de Programação. Professores têm treinado seus alunos para participarem desses eventos, mas a falta de plataformas adequadas dificulta o sucesso no preparo dos competidores. Para suprir essa demanda, foi desenvolvida a aplicação web Kheiron para o auxílio pedagógico, aplicação que facilita o gerenciamento e acompanhamento dos estudos dos alunos por parte do docente e fornece ferramentas de análise e de repasse de conteúdo, além de permitir que o aluno seja atendido diretamente pelo docente/treinador ou por um robô (bot) dotado de Inteligência Artificial Generativa. Para o desenvolvimento deste trabalho, aplicou-se uma pesquisa exploratória, seguida de uma revisão bibliográfica.
Concepciones arquetípicas y críticas del sentido común: un enfoque desde la filosofía práctica
Authors: Morro Delgado Joan
Published: August 2024

El sentido común es un concepto controvertido en filosofía y ciencias sociales. Por lo general, se entiende como una intencionalidad compartida, un conjunto de intuiciones y creencias autoevidentes que guían nuestras ideas y conductas. Cuando se tiende a discrepar es al discutir el origen y el alcance de dicha intencionalidad. A partir de una lectura crítica de diferentes planteamientos contemporáneos del sentido común (G. E. Moore, C. Geertz, A. Gramsci, E. Laclau, C. Mouffe, y C. Pérez), en este artículo presento dos concepciones arquetípicas de este conjunto de intuiciones y creencias y dos críticas al respecto con una finalidad de síntesis para la filosofía práctica. El objetivo general es mostrar la relevante correlación entre nuevas tecnologías y sentido común y la necesidad de entender dicha correlación críticamente para la reflexión ética y política.
Capabilities and Education in Latin America
Authors: González M. Sebastián Alejandro , López Gómez Catalina
Published: August 2024

This paper explores the fundamental theses of the capabilities approach and differentiates it from notions of development that are more focused on the generation of wealth and growth. The paper emphasizes the importance of action in the development of life projects and describes the importance of emancipation in exercising freedoms. It then describes the education challenges from the perspective of the capabilities approach. It situates the importance of this approach in the Latin American context, where freedom is closely linked to the pursuit of social justice. Finally, it describes the different areas of application of the capabilities approach in education and points out the limitations of formal education in the contemporary world.
Crítica retórica y retórica filosófica en la “nueva retórica” de Kenneth Burke
Authors: González de Requena Farré Juan Antonio
Published: August 2024

En el escenario contemporáneo, caracterizado por la rehabilitación de la retórica, Kenneth Burke (1897-1993) ha realizado contribuciones decisivas que lo han convertido en una de las figuras fundamentales de la “nueva retórica” y, quizá, de un posible “giro retórico”. Mediante una sistematización de las proyecciones de la retórica en los distintos momentos de su pensamiento, este artículo identifica los aportes de Burke a la retórica contemporánea, sopesa las transformaciones que su enfoque introduce en la tradición retórica y discute los alcances de su crítica retórica. En su obra, asistimos a una amplificación de la crítica retórica hasta la formulación de una retórica dialéctica y filosófica que se perfila, sucesivamente, como una retórica de la filosofía, una filosofía de la retórica y una filosofía retórica o dramática. La crítica retórica burkeana constituye una vía privilegiada para cualquier proyecto de retórica general y de renovación de la retórica.
Animalidad en la individuación simondoniana
Authors: Di Iorio German E.
Published: August 2024

Este escrito explora La individuación a la luz de las nociones de forma y de información de Gilbert Simondon, tomando como hilo conductor la cuestión de la animalidad. Se analiza si en dicho libro hay un corte antropológico que permita separar tajantemente la individuación del hombre de la de los otros animales. La hipótesis inicial es que tal concepción de la antropogénesis, con el excepcionalismo humanista y el especismo que implica, resulta incompatible con el sistema allí desplegado por Simondon. A lo largo del trabajo se enfatiza que la ontología de Simondon, con sus ambigüedades y tensiones en torno a la cuestión, exige pensar otro concepto de “animalidad” que aquel que hereda de la tradición filosófica contra la que se enfrenta.
Evaluation of the Family Burden and Social Isolation Status of Mothers of Children with Special Needs
Authors: Şahin Hande , Çakmak Aygen , Erdem Yurdagül
Published: August 2024

Introduction: The high family burden in families with children with special needs causes social isolation. The current research was conducted as a descriptive study to determine the family burden and social isolation status of mothers of children with special needs and the influencing factors.
Method: The researchers conducted the present study on 180 Turkish mothers selected by convenience sampling and collected data using the "Information Form," "Social Isolation Scale," and "Family Burden Assessment Scale for Families of Children with Intellectual Disability." They performed data analysis using the program SPSS. The study, which examined the social isolation status and family burdens according to some demographic variables, calculated skewness and kurtosis values. Since the results showed that the distributions were within acceptable limits, the researchers used ANOVA and t-test analysis to compare the means and multiple regression analysis to determine the possible predictors of the total scores from the scales.
Findings: The findings showed that respondent mothers had a moderate level of social isolation and a high level of family burden. With an increase in respondent mothers' age and education level, their social isolation levels decreased. Furthermore, with an increase in respondent mothers' education level, family burden decreased. However, with the increasing number of children with special needs respondent mothers had, their family burden increased. The family burden of respondent mothers who reported that having children with special needs caused them to experience problems with their social communication and spouses also increased.
Discussion: The impact of having a child with special needs on social communication and the number of children with special needs are important predictors of both social isolation and family burden.
Ultra-thin Polarization Converter Using Single Layer Metasurface for X-, Ku-, and K-Band Applications
Authors: Arslan Madak Seher Şeyma , Teber Ahmet , Topkaya Ramazan
Published: August 2024

In this article, an ultrathin (λ0/14.9), single layer, reflective type polarization converter for either linear-to-circular (LP-to-CP) or linear-to-linear (LP-to-LP) polarization conversion is reported. It has been demonstrated to achieve the LP-to-CP conversion at two separate frequency bands, including 11.52-11.84GHz and 19.83-20.01GHz. The circular polarization type is specified as a right-hand circular polarization (RHCP) for the first band and a left-hand circular polarization (LHCP) for the second band. In both of frequency bands, the metasurface structure reveals highly efficient features. Besides that, the metasurface structure exhibits highly efficient features within 3-dB bandwidths of 10.29-12.58GHz and 19.32-20.50GHz. Crucial parameters of polarization conversion such as ellipticity, axial ratio, and |Eco|/|Ecross| are confirmed to be in good agreement with another one. The metasurface structure's angular stability up to 200 oblique incidence angles makes it useful for beam scanning antennas. CST Microwave Studio program is utilized to carry out extensive simulations. This presented study offers a low cost, relatively high-performance, ultrathin polarization converter capable of linear-to-linear and circular polarization conversion in the X-, Ku-, and K-bands.
Alyssum sibiricum Willd. Bitkisinin GC-MS Analizi ve Antioksidan Aktivitesinin Tayini
Authors: Argon Merve , Çalışkan Hilmican , Cakır Cansel , Öztürk Mehmet , Şabudak Temine
Published: August 2024

Bu çalışmada, Trakya Bölgesinde yetişen Alyssum sibiricum Willd. bitkisinin ham ekstrelerinde antioksidan aktivitesi incelenmiş ve hekzan ekstresinin kimyasal içeriği GC-MS ile belirlenmiştir. Bu amaçla; Alyssum sibiricum sırasıyla hekzan, kloroform, etil asetat ve metanol ile ekstrakte edilmiş ve bu ekstrelerde antioksidan aktivite; DPPH, ABTS, β-Karoten-linoleik asit renk giderim aktivitesi ve CUPRAC yöntemleri kullanılarak araştırılmıştır. Antioksidan aktivite sonuçlarına göre; tüm yöntemlerde, en yüksek antioksidan aktiviteyi metanol ekstresi göstermiştir. A. sibiricum bitkisinin hekzan ekstresinin GC-MS sonuçlarına göre, 41 bileşik tespit edilmiştir. Bu bileşikler arasında; n-Dokosan (%23.24), palmitik asit (%15.02), laurik asit (%7.67) ve 1-hekzadekanol (%5.82), hekzan ekstresinin temel bileşiklerini oluşturmuştur.
Yenisolöz ve Fındıcak (Gemlik, Türkiye) Erken – Orta Eosen Yaşlı Nummulites’lerin Biyometrisi ve Filojenisi
Authors: Ünal Esin , Örçen Sefer
Published: August 2024

Bu çalışmada, kuzeybatı Türkiye’de Fındıcak ve Yenisölöz lokalitelerinde (kuzeybatı Anadolu) yüzeyleyen Küviziyen – Alt Lütesiyen (Alt – Orta Eosen) yaşlı çökelme ortamlarından alınan tane Nummulites formundaki ölçümlerle biyometrik analizi yapılarak, Nummulites filojenisine ait yaklaşımda bulunulmuştur. Özellikle karbonat egemen çakıltaşı, kumtaşı, silttaşı, kireçtaşı, marn istiflenmesinin gözlemlendiği Küviziyen (Alt Eosen) yaşlı Fındıcak Formasyonu, Alt Lütesiyen (Orta Eosen) yaşlı Dürdane Formasyonu, Priyaboniyen (Üst Eosen) yaşlı Soğucak Formasyonu) birimlerinden elde edilen tane Nummulites bireylerinin makrosferik ve mikrosferik formları incelenmiştir. Işınsal-granüllü, ışınsal-beyaz lekeli özellikli toplanan Nummulites bireylerinin makrosferik ve mikrosferik formlarının biyometrik analizi sonucunda Nummulites burdigalensis de la Harpe (Küviziyen), Nummulites uranensis de la Harpe (Alt Lütesiyen) türleri tanımlanmıştır. Biyometrik ölçümlerden 2 lokalite için verilerin dökümünün yer aldığı bir çizelge oluşturulmuştur. 2 türün birbirleriyle örtüşen dağılımları sonucunda; Nummulites’lerin cins özellikleri, ilk locadan başlayarak gelişim evreleri, ergin birey olana kadar geçirdiği değişimlere ait bazı ipuçları elde edilmiştir. Bu değişimler gözetilerek inceleme alanı Nummulites’lerinin filojenetik gelişimleri, altları çizili türler kapsamında temsil olunmak üzere Nummulites burdigalensis → uranensis soy çizgileri ortaya konulmuştur.
A SYSTEMATIC REVIEW ON THE EFFECTIVENESS OF BRAIN-BREAKS® VIDEO PROGRAMMING ON ACADEMIC PERFORMANCE AND PHYSICAL ACTIVITY OF SCHOOL CHILDREN
Authors: Kuan Garry , Chin Mingkai , Kueh Yee Cheng , Sabo Abdulwali , Mok Magdalena Mo Ching , Balasekaran Govindasamy , Chang Yu-kai , Edginton Christopher R. , Culpan Ian , Popeska Biljana , Durstine J. Larry
Published: August 2024

Purpose: This study aimed to complete a systematic review of the effect of the Brain Breaks® video program on academic performance and health-related outcomes among schoolchildren.
Methods: A literature search was performed using Scopus, PubMed, ResearchGate, ScienceDirect, and Google Scholar databases to identify published manuscripts from December 2017 to December 2023. Dissertations, theses, monographs, and commentaries were excluded from this review.
Results: A total of 15 studies were included in the review. Most studies applied quasi-experimental design and were conducted in Asia and Europe with children. Nine of these studies found that Brain Breaks® improved students' attitudes toward physical activity (PA), and two found that it improved their PA levels. The other studies found that Brain Breaks® improved students' academic performance, perceived pros and cons of PA, transtheoretical model (TTM) constructs, motivation to participate in PA, cognitive function, muscle strength, muscular endurance, and flexibility, as well as the fitness knowledge test and the Fitnessgram test battery results.
Conclusion: It is thought that the Brain Breaks® web-based online video program has the potential to improve the academic performance and health-related physical fitness of school children