bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing CPR Training through Aerobic Exercise
Authors:   Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
Published: January 2025

Aerobic exercise is known for its many health benefits, such as improved cardiovascular fitness and weight loss. Interestingly, acute aerobic exercise has been shown to improve learning and cognitive function. However, the relationship between acute aerobic exercise and learning practical cardiorespiratory resuscitation (CPR) has not yet been established. The aim of this study was to investigate the effect of acute moderate-intensity aerobic exercise on the learning of CPR knowledge and skills and the effects on the concentration of brain-derived neurotrophic factor (BDNF). A total of 50 participants (mean age: 30.96 + 4.33 years) were randomly assigned to either the exercise or control group. The exercise group completed a 30-minute run on the treadmill at moderate intensity, while the control group rested without any physical activity. Knowledge and acquisition of CPR skills were assessed before and after the intervention. The results revealed a significant difference between the exercise group and the control group immediately post-intervention, accompanied by a notable increase in serum BDNF levels (P < 0.05). The findings suggest that acute aerobic exercise can improve CPR learning, possibly through BDNF-mediated neurobiological mechanisms. This research contributes valuable insight into the effects of exercise on cognition, which in turn has implications for CPR learning programmes to optimise the learning outcome of CPR.
Pansinusitis-associated Superior Subperiosteal Abscess in An Adolescent: A Case Report
Authors:   Department of Ophthalmology and and Visual Science, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Published: January 2025

Subperiosteal abscess is a serious orbital complication of pediatric rhinosinusitis. Orbital complications from rhinosinusitis are uncommon but require prompt and effective treatment to prevent disastrous consequences such as permanent blindness. Our case demonstrated a rare but potentially hazardous orbital complication of untreated sinusitis. A 14-year-old boy presented with worsening right eye proptosis and profoundly reduced vision. Computed tomography (CT) of the brain, orbit and paranasal sinuses revealed a right superior subperiosteal abscess with pansinusitis. He received both medical and surgical treatment within 48 hours of admission, consisting of broad-spectrum intravenous ceftriaxone and metronidazole and emergency functional endoscopic sinus surgery (FESS). He improved tremendously upon completion of treatments. Prompt and aggressive treatment combining both surgical and medical approaches in treating superior subperiosteal abscess may be necessary to avoid morbidity.
Defying All Odds: Successful Thrombolysis in a Nonagenarian with Posterior Circulation Infarct
Authors:   Neurology Unit, Department of Medicine, Level 8, Clinical Block, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras Kuala Lumpur, Malaysia.
Published: January 2025

A delay in recognising acute posterior circulation infarct (POCI) can cause a delay in treatment and high mortality rate. There has been an increasing trend in incidence of stroke among the elderly. Treating acute stroke in elderly has been challenging due to the lack of data on the functional outcome and mortality risk. A 97-year-old woman had left sided weakness upon waking up from sleep and dizziness two days prior. Upon arrival, her Glasgow Coma Scale (GCS) was E3V4M6, BP 162/112 mmHg, NIHSS score 10, left sided power 3/5 and right sided power 4/5. Her computed tomography (CT) angiography brain showed P2 segment of right posterior cerebral artery and distal basilar artery thrombosis, with a posterior circulation territory mismatch. Thrombolysis was given immediately. She was discharged with NIHSS 5, GCS E4V5M6 and power bilateral limbs 4/5. She was put on lifelong Apixaban for stroke prevention and underwent post-stroke rehabilitation. The time of occlusion was decided based on the time a patient was last seen well. Studies have shown that patients aged 80 years and above presenting within 3-4.5 hours from symptoms, perform well with both intravenous thrombolysis and thrombectomy, with no increased risk for intracranial hemorrhage and death.
Early Recognition and Intervention of De Winter Syndrome: A Case Report
Authors:   Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia.
Published: January 2025

De Winter syndrome is a rare but important ST-elevation myocardial infarction (STEMI) equivalent, that is characterised by severe stenosis of the left anterior descending artery (LAD). It can be easily misdiagnosed due to its atypical electrocardiogram (ECG) pattern which causing a delay in reperfusion, hence increases risk of mortality. Herein, we reported a 38-year-old man presented to the emergency department (ED) with initial ECG showed hyperacute T wave, which later evolved to de Winter syndrome ECG pattern after serial ECG were done. He was immediately referred to the cardiology team and underwent immediate percutaneous coronary intervention (PCI) to revascularise the stenosis found at the left anterior descending artery (LAD). He showed good outcomes and no complication after the procedure. This paper aimed to shed light on the importance of early identification, right diagnosis and treatment in De Winter syndrome case to avoid complications.
Death due to Liquified Petroleum Gas Inhalation Augmented with Plastic Bag Suffocation
Authors:   Forensic Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
Published: January 2025

Liquified petroleum gas usually contains butane and propane, which are the family of aliphatic hydrocarbons that are colourless and commercially available, sometimes abused as a volatile inhalant to obtain psychoactive effects or to commit suicide. Instances of non-suicidal death resulting from a combination of inhalation of hydrocarbon from liquified petroleum gas and plastic bag suffocation are uncommonly reported. A 44-year-old man was allegedly discovered naked, only partially covered with the comforter, inside his bedroom, with the head covered with a black and thin plastic bag connecting to a cooking gas cylinder tank. The plastic bag was modified to prevent a gas leak. Additionally, pornographic paraphernalia was found on the mobile phone beside him. No suicidal risk was noted before death. The investigation of deaths associated with the inhalation of liquified petroleum gas, together with the plastic bag around the head, is crucial for comprehending the underlying manner of death in such fatalities. The present case prompts inquiries into accidental, as the absence of clear suicidal indicators suggests the possibility of unintentional death.
A Flecha de Dois Gumes
Authors: Dumont Ágata Cristina Kaiser
Published: January 2025

O tempo não se apresenta somente como elemento estruturador, mas como recurso artístico em  Memórias póstumas de Brás Cubas. O tempo aqui apresentado transcende a limitação de aspecto constituinte da narrativa e  surge, na obra em questão, como mais um instrumento utilizado pelo escritor para a construção da arte literária.
Uma Leitura da Escrita Consolatória Senequiana
Authors: Veloso Maria de Fátima
Published: January 2025

Este ensaio mostra a estrutura do gênero literário  das Consolações e algumas das variações introduzidas por Sêneca aos recursos retóricos clássicos na escrita do Ad Helviam — De Consolatione.
Rompimento de Fronteiras nas Linguagens do Grupo Oficcina Multimédia
Authors: Nunes Roberson de Sousa
Published: January 2025

Este ensaio objetiva apresentar, em linhas gerais,  o caráter interdisciplinar da pesquisa de linguagens artísticas do Grupo Oficcina Multimédia, em diálogo com o teatro pós-moderno e suas representações performáticas.
Reinventing Cartography
Authors: Silva Daniela Cordeiro Soares
Published: January 2025

By taking Lahiri’s map imagery as a starting point, I reflect on the author’s portrayal of the Indian diaspora and the way she builds up a narrative that questions many of the ontological and solid beliefs established by hegemonic discourses, including the concepts of fixed identities and gender roles.
Estilhaços literários da Guerra de Canudos
Authors: Oliveira César Gonçalves de
Published: January 2025

Este artigo discorre sobre leituras literárias da Guerra de Canudos, mais especificamente sobre as crônicas de Olavo Bilac e o romance Os jagunços, de Afonso Arinos, bem como possíveis contribuições destes autores para o livro Os sertões, de Euclides da Cunha.
O homem
Authors: Freire Isabel Guimarães Rodrigues
Published: January 2025

Com o presente artigo pretendemos demonstrar os resíduos da mentalidade medieval no romance O homem, de Aluísio Azevedo, abordando os aspectos presentes na obra que remetam a possessão sexual, vampirismo e pecado original. Além do romance em questão, utilizamos estudos teóricos elaborados por Roberto Pontes sobre residualidade e estudos referentes à Idade Média.
Às margens
Authors: Silva Aline Bezerra da
Published: January 2025

Baseado em uma leitura analítica do livro São Bernardo, de Graciliano Ramos, este trabalho fomenta a discussão sobre os processos de violência e empoderamento, com vistas ao desenvolvimento crítico, capaz de garantir o desenvolvimento dos estudos literários, em especial, da obra de Graciliano.
Do quarto de despejo à sala de estar
Authors: Pereira Luciara
Published: January 2025

Este trabalho pretende indagar sobre certas implicações da presença no mercado editorial de uma narrativa como Quarto de despejo: diário de uma favelada, de Carolina Maria de Jesus, à luz da noção de campo literário, formulada por Pierre Bourdieu. A discussão adquire relevância por esse discurso, apesar de advir de um espaço historicamente desprestigiado, uma favela brasileira, negociar e disputar sua entrada e permanência no cenário da cultura letrada.
Violência, silenciamento, literatura
Authors: Côrtes Cristiane Ribeiro
Published: January 2025

Este artigo discutirá o conceito do Fora, de Maurice Blanchot, a partir de dois autores contemporâneos, Herta Müller e Ítalo Calvino. Pretende-se desenvolver uma reflexão no que tange aos tipos de violência existentes na sociedade e tratados na Literatura a partir de uma perspectiva aparentemente desconectada de sua verdadeira intenção. Tendo como mote a metáfora do lixo, os textos eleitos deverão dar conta de ilustrar em que medida a profundidade da escrita no Fora pode elucidar de uma forma significativamente os processos de trauma sofridos no plano da realidade. O texto procurará evidenciar a dificuldade de se lidar com tamanha violência no campo da linguagem. Na escrita, os autores optam por um viés externo àquele que evidencia um problema, negando a linguagem, silenciando sobre o que faz sentido, dialogando com o Fora e atribuindo uma significância mais próxima, não da realidade, mas do contexto real referente às situações de violência.
DISCURSO RELIGIOSO EM OLHAI OS LÍRIOS DO CAMPO
Authors: Bessa Daniela Borja
Published: January 2025

Este artigo procura demonstrar a importância do discurso religioso, principalmente do texto bíblico do Sermão da Montanha, na constituição dos personagens, assim como da relação existente entre aceitação de Deus, descoberta de um sentido para a vida e luta contra as injustiças sociais.
FORMA E MATÉRIA NA SINTAXE ROSIANA
Authors: Sobrinho João Batista Santiago
Published: January 2025

Pretendo demonstrar que os conceitos de Gaston Bachelard, forma e matéria contribuem para a compreensão do temperamento literário do Escritor Guimarães Rosa e seus múltiplos narradores.
O CAOS LITERÁRIO
Authors: Margutti Vivian Bernardes
Published: January 2025

Sugerimos a existência de pontes entre a arte e a ciência, através da releitura e apropriação do conceito de caos da matemática da complexidade para o campo literário. Supomos que a literatura contemporânea apresenta aspectos que podem ser ligados a este conceito. Com o intuito de demonstrar tal afirmação, desenvolvemos uma análise de Cidade de Vidro, de Paul Auster, destacando suas características “caóticas”.
ENTRE DOBRADIÇAS E DOBRADURAS
Authors: Barbosa Josane Fátima
Published: January 2025

Este trabalho aborda a construção das personagens dobradiçasde Stella Manhattan e das personagens dobraduras de Brazil.Essa construção é considerada estratégia de leitura do mundocontemporâneo.
JOSÉ PAULO PAES
Authors: Silva Júnior Maurício Guilherme
Published: January 2025

O referido ensaio pretende discutir as principais características da poesia e da obra intelectual de José Paulo Paes, assim como contextualizar o legado do autor no panorama da literatura brasileira e promover a análise crítica de seu livro póstumo, Socráticas – poemas.
The ‘Nothing Lasts!’ Motif in Stoyan Mihaylovski’s Sonnets
Authors: Mihaylov Kalin
Published: January 2025

The paper focuses on the 1895 collection ‘Philosophical and Satirical Sonnets’ by Stoyan Mihaylovski (1856–1927), a prominent Bulgarian poet and public figure. This collection allows researchers to study how the sonnet, a form of literary expression typically associated with Western Europe, settles in and makes itself noticeable in a creative path containing a vast number of East European features. The analysis begins with the sonnet ‘Nothing Lasts!’, which affirms the idea that human efforts, strivings and ideals are, after all, worthless. While this idea, among others in Mihaylovski’s collection, is consistent with ancient philosophical traditions, associated with Horace and his poem ‘Exegi monumentum’, the Bulgarian poet deals with it in an opposite vein: it makes no sense to erect a verbal monument untouched by a human hand. From here the analysis moves on to French Renaissance poet Pierre de Ronsard (1524–1585), as the ‘carpe diem’ motif (another reference to Horace), as well as acedia (a form of sadness or grief, characteristic of the Renaissance sonnet after Petrarch) are present in both Ronsard and Mihaylovski’s works. Acedia is discussed in connection with the two previously mentioned Horace motifs. The analysis leads to the conclusion that both poets search for a way out of acedia in their lyrical worlds. While Ronsard opts for the horizon of love and personal happiness here and now, Mihaylovski reaches out for a wider and more universal philosophical horizon, which excludes the possibility of such happiness. This is why Mihaylovski’s collection leans towards an escape from acedia that presents the ego dissolving in an unconscious existence, unaffected by the vicissitudes of fate and the triumph of destruction in the course of world history.
Curation, Algorithmic 'Caregiving' and Collective Archival Practices. Rethinking the Archival Work of Culture in Streaming Media
Authors: Re Valentina
Published: January 2025

This paper is structured around the central themes of archive, network, and algorithmic personalisation, moving from the historical context of digital media and the metaphors of the archive, to the specific case of streaming television. I argue that streaming aggregators such as Netflix are shifting the focus of curatorial or caretaking activity from content to consumers - from criteria of selection, classification, and presentation of content to the effectiveness of automated processes masked as ‘caregiving’ practices. This shift has the potential to significantly change, or even invalidate, the theoretical debate on the work of culture as ‘archival work.’ The paper discusses the hypothesis that algorithmic personalisation in streaming television replaces the collective issue of the formation and circulation of knowledge (seen as the tension between what I define as the ‘archive’ and the ‘network’ models), reducing it to a matter of taste and individual choice to be ‘taken care of.’ In the conclusion, I suggest that the work of culture as archival work is still active in the grey zone of digital ‘piracies’ and informal circulation, and that ‘curatorial’ impulses on the part of viewers emerge as a collective archival activity. I argue that the dialectic between formal and informal practices, and between the archive and network models, represents a vital area of inquiry for the study of streaming media that still deserves to be thoroughly scrutinised.
VIEW Journal: Time for a Jubilee
Authors: Editors-in-chief VIEW
Published: January 2025

Editorial letter to reflect on twelve and a half years of VIEW Journal.
Beyond the Flow, from Tape to Digital: Insights from Mediaset's Archives
Authors: Rossi Emiliano
Published: January 2025

This study delves into the evolution of Mediaset’s audiovisual archive, tracing its development from a mere storage facility to a sophisticated digital repository. It examines the strategic importance of archives in the television industry, focusing on the retrieval, storage, cataloguing, and commercial re-use of TV content. The paper highlights the implementation of AI and automation in managing digital resources, and the unique model adopted by Mediaset for content retention. The analysis underscores the logistical, technological, and organisational functions of the archives, and their impact on production, distribution, and long-term preservation processes.
Knowledge, attitude and practice of hemovigilance among health care professionals and hemovigilance study in a tertiary care hospital
Authors: Moqthadeer Ahamed Syed , Manjunatha Poornachandra Somwarpet , Milton Beulah , Ranjini Siva
Published: January 2025

Background: Clinical staff’s wisely varying transfusion techniques result in the misuse of blood products and endanger patient safety. Hemovigilance seeks to improve the quality and safety of blood transfusions. This study aimed in order to find out the knowledge, attitude and practice of hemovigilance among HCP’s and to know the incidence and prevalence of ATR in a tertiary care hospital.
Methods: An observational study of 120 HCP’s is planned to be conducted at Hospital. Pre-validated KAP questionnaire were issued. The frequency of ATR was recorded in TRRF form. At end of the study through collected data, we will subject it to statistical analysis.
Results: From the view of 120 HCP, only 40 % had knowledge on the hemovigilance, and a whopping 74% is not practicing Hemovigilance safety measures. But we are happy to see that 71% have a positive attitude. Out of 40 transfusion reactions, a majority of patients had encountered FNHTR and allergic reaction, that is of 30%. Followed by delayed haemolytic reaction, TACO, TAD of 10%. And 5% did get hypotensive reaction and TRALI. Coming to type of blood component administered PRBC (60%), whole blood and FFP  20% each were seen. Out of 40 ,30 female patients (75%) and 10 (25%) reported ATR.
Conclusions: Even though The HCP have positive attitude towards blood safety, the knowledge and practice of HCP is proven to be poor. The frequency of ATR showed although they are less severe if no strict monitory actions are not taken, they may turn life threatening.
Dengue outbreak of 2023 in the state of Uttar Pradesh, North India: lesson learnt and way forwards
Authors: Bashar M. Abu , Begam Nazia
Published: January 2025

Dengue, a vector borne viral disease, is endemic in most areas of India and sometimes causes yearly epidemics. Each of the dengue outbreaks causes high death and morbidity, which has a significant socioeconomic impact. In the year, 2023, India had clocked 2, 89,235 dengue cases with 485 deaths in the year 2023, highest in the last 5 years, as per the information provided by the National Centre for Vector Borne Diseases Control. Northern India is most severely impacted by each outbreak. In the state of Uttar Pradesh, the most populous state of India, there have been more than 35,000 confirmed cases of dengue and 36 deaths reported in 2023 alone. Patients are being reported from urban as well as semi-urban, and rural areas. It is necessary to properly monitor the dengue cases through both active and passive disease surveillance in order to ensure prompt case management if dengue outbreak control is to be achieved.
Assessing impact: a study of India's vaccine preventable diseases
Authors: Sharma Ankita , Sharma Somya , Sharma Divyansh
Published: January 2025

The universal immunization programme (UIP) is one of the most cost-effective methods to enhance public health. It is administered by the national rural health mission under the aegis of the ministry of health and family welfare. Despite India's 50-year history of vaccines, vaccine-preventable diseases (VPDs) still cause over 5,00,000 fatalities annually. The present study assesses the UIP 's success in decreasing VPDs in India. The data from 2006 to 2018 was taken from Indiastat.com. Since the research aimed to assess the success of UIP across India, achievements under UIP for each vaccination, i.e., Bacillus Calmette-Guerin; oral polio vaccine-1, 2 and 3; diphtheria pertussis tetanus-1, 2 and 3 and measles, was compared with the cases and deaths owing to the diseases; as per NRHM division and health index (4th round) scores given by NITI Aayog, separately. Data analysis was conducted in MS excel (2019 version). Vaccination achievements varied significantly as per NRHM and NITI Aayog health index, with HFSNNE and MI regions outperforming each other’s. Cases of polio and tetanus were lowest in HFSNE and LI states. Deaths due to diphtheria and measles, mirrored regional disparities with NHFSL and NI states having higher burden. To reduce mortality due to VPD in children, enhancing reporting networks and cross-border cooperation in vaccination strategies are crucial. Policy recommendations include targeted interventions, educational campaigns, infrastructure improvements, incentives, monitoring, evaluation strengthening, policy flexibility, community engagement, capacity building, research, and a phased implementation plan.
Reflection of Separate Provisions of the General Part of the Criminal Code of the Russian Federation in Provisions of Its Special Part as a Violation of System Coherence: A Dialogue and a Discussion
Authors:   Professor of the Department of Criminal Law and Criminology of the Kuban State University, LL.D., Professor, Prokhorova Marina L. , Gorenko Maksim G. ,   Lecturer of the Department of Criminal Law and Criminology of the Kuban State University, PhD (Law)
Published: January 2025

The article is devoted to the study of the reflection in the norms of the Special part of the Criminal Code
of the Russian Federation of certain provisions of its General part through the prism of violation of systemic
coherence. The authors, having chosen the form of presentation of the material in the form of a dialoguediscussion,
consistently express their own point of view on various aspects of the representation in articles of the
Special part of the Criminal Code of the Russian Federation of norms on organization, incitement, aiding and
abetting an unfinished crime (name, criminal law assessment, construction). In conclusion, conclusions are
drawn on these aspects, the problem of imperfection of general regulations on the types of accomplices in crime
and the institution of an unfinished crime, the need for their modernization is noted.
Treatment of Subcutaneous Sarcoidosis with Hydroxychloroquine in a Hepatitis B Carrier Patient: A Case Report
Authors: Sezer Tuna , Polat Mualla , Kandil Yasin Hakan , Erdoğan Düzcü Selma
Published: January 2025

Sarcoidosis is a disorder of unknown etiology affecting many systems and characterized by non-caseating granulomas. Subcutaneous sarcoidosis is the rarest form of specific lesions in cutaneous sarcoidosis. It occurs more frequently in the fourth decade of life and is more common in females than in males. Multiple asymptomatic to slightly painful, firm, mobile, round to oval, skin-colored, or erythematous nodules frequently occur in a bilateral and asymmetric pattern on the extremities. In the differential diagnosis, other diseases presenting with subcutaneous nodules should be excluded. Here, a case of subcutaneous sarcoidosis in a 51-year-old female hepatitis B carrier patient who partially responded to topical steroid treatment and was successfully treated with hydroxychloroquine was presented. In subcutaneous sarcoidosis, patients should be evaluated for systemic involvement. Hydroxychloroquine should be considered among the treatment options.
Association of autistic personality traits with the EEG scores in non-clinical subjects during the facial video viewing
Authors: Savostyanov A. N. , Kuleshov D. A. , Klemeshova D. I. , Vlasov M. S. , Saprygin A. E.
Published: February 2025

A software information module of the experimental computer platform “EEG_Self-Construct” was developed and tested in the framework of this study. This module can be applied for identification of neurophysiological markers of self-referential processes based on the joint use of EEG and facial video recording to induce the brain’s functional states associated with participants’ personality traits. This module was tested on a group of non-clinical participants with varying degrees of severity of autistic personality traits (APT) according to the Broad Autism Phenotype Questionnaire. The degree of individual severity of APT is a quantitative characteristic of difficulties that a person has when communicating with other people. Each person has some individual degree of severity of such traits. Patients with autism are found to have high rates of autistic traits. However, some individuals with high rates of autistic traits are not accompanied by clinical symptoms. Our module allows inducing the brain’s functional states, in which the EEG indicators of people with different levels of APT significantly differ. In addition, the module includes a set of software tools for recording and analyzing brain activity indices. We have found that relationships between brain activity and the individual level of severity of APT in non-clinical subjects can be identified in resting-state conditions following recognition of self-referential information, while recognition of socially neutral information does not induce processes associated with APT. It has been shown that people with high scores of APT have increased spectral density in the delta and theta ranges of rhythms in the frontal cortical areas of both hemispheres compared to people with lower scores of APT. This could hypothetically be interpreted as an index of reduced brain activity associated with recognition of self-referential information in people with higher scores of autistic traits. The software module we are developing can be integrated with modules that allow identifying molecular genetic markers of personality traits, including traits that determine the predisposition to mental pathologies.
Reconstruction and computer analysis of the structural and functional organization of the gene network regulating cholesterol biosynthesis in humans and the evolutionary characteristics of the genes involved in the network
Authors: Mikhailova A. D. , Lashin S. A. , Ivanisenko V. A. , Demenkov P. S. , Ignatieva E. V.
Published: February 2025

Cholesterol is an essential structural component of cell membranes and a precursor of vitamin D, as well as steroid hormones. Humans and other animal species can absorb cholesterol from food. Cholesterol is also syn­thesized de novo in the cells of many tissues. We have previously reconstructed the gene network regulating intra­cellular cholesterol levels, which included regulatory circuits involving transcription factors from the SREBP (Sterol Regulatory Element-Binding Proteins) subfamily. The activity of SREBP transcription factors is regulated inversely depending on the intracellular cholesterol level. This mechanism is implemented with the participation of proteins SCAP, INSIG1, INSIG2, MBTPS1/S1P and MBTPS2/S2P. This group of proteins, together with the SREBP factors, is designated as “cholesterol sensor”. An elevated cholesterol level is a risk factor for the development of cardiovas­cular diseases and may also be observed in obesity, diabetes and other pathological conditions. Systematization of information about the molecular mechanisms controlling the activity of SREBP factors and cholesterol biosyn­thesis in the form of a gene network and building new knowledge about the gene network as a single object is extremely important for understanding the molecular mechanisms underlying the predisposition to diseases. With a computer tool, ANDSystem, we have built a gene network regulating cholesterol biosynthesis. The gene network included data on: (1) the complete set of enzymes involved in cholesterol biosynthesis; (2) proteins that function as part of the “cholesterol sensor”; (3) proteins that regulate the activity of the “cholesterol sensor”; (4) genes encod­ing proteins of these groups; (5) genes whose transcription is regulated by SREBP factors (SREBP target genes). The gene network was analyzed and feedback loops that control the activity of SREBP factors were identified. These feedback loops involved the PPARG, NR0B2/SHP1, LPIN1, and AR genes and the proteins they encode. Analysis of the phylostratigraphic age of the genes showed that the ancestral forms of most human genes encoding the enzymes of cholesterol biosynthesis and the proteins of the “cholesterol sensor” may have arisen at early evolutionary stages (Cellular organisms (the root of the phylostratigraphic tree) and the stages of Eukaryota and Metazoa divergence). However, the mechanism of gene transcription regulation in response to changes in cholesterol levels may only have formed at later evolutionary stages, since the phylostratigraphic age of the genes encoding the transcription factors SREBP1 and SREBP2 corresponds to the stage of Vertebrata divergence.
Przydatność analizy korpusowej do badania wartościowania w recenzjach awansowych
Authors: Grech Michał
Published: January 2025

Celem niniejszego artykułu jest przedstawienie metodologii oraz wstępnych wyników badań nad wartościowaniem i jego językowymi wykładnikami na przykładzie recenzji w postępowaniach awansowych. Analizie poddano recenzje habilitacyjne z dyscypliny językoznawstwa, pobrane z archiwum Centralnej Komisji ds. Stopni i Tytułów. Główny korpus badawczy składa się z 91 recenzji z konkluzją negatywną oraz korpus referencyjny z 92 recenzji z konkluzją pozytywną. Głównym celem badań jest ocena możliwości wykorzystania metod korpusowych do analizy tekstów recenzji awansowych. Problematyka badawcza obejmuje identyfikację elementów poddawanych ocenie, szczególnie negatywnej, kryteriów oceny oraz językowych środków i zabiegów stosowanych do wartościowania. Metodologia badań opiera się głównie na porównawczej analizie korpusowej, wzbogaconej analizą kolokacji i konkordancji. Uzyskane wyniki potwierdzają możliwość zastosowania tej metody do analizy szerszego zbioru tekstów, umożliwiając także dalsze, pogłębione analizy kolejnych dokumentów.
Sing A Song for Home: How Displaced Iranian Song-Writers in LA Conceive of Home and Homeland
Authors: Morshedi Pouya , Van den Scott Lisa-Jo K.
Published: January 2025

We ask how being apart from home impacts the very definition of home. We conducted a content analysis of songs produced by Iranians who have left their first “home” in Iran and resettled in Los Angeles. Our findings suggest that distance from one’s home expands the definition and image of home from a structure where one dwells and calls home, to an imagined community at the personal (home family), local (hometown), and regional (homeland) levels. The 1979 revolution in Iran caused many people, including singers and songwriters, to immigrate. Many of them moved to Europe and North America. We analyzed songs from 1979 to 1999, produced in Los Angeles, as the heart of Iranian pop music after the revolution, focusing on the concept of “home.” Four main themes emerged: the “body of the home,” which includes windows, niches, and gardens; “homeland as home;” “home and family;” “home as a heaven to remember and a haven for return,” which involves home as a place for making memories and recalling them and home as a retreat. We explain how these themes are related to Iran’s situation post-revolution, the image of the Iranian home, and the singers’ situation in Los Angeles after the revolution. The most significant finding is the relationship between home and homeland. Songs use home as a metaphor for the homeland, even when describing the body of the home. The sadness about the destroyed home, hope to return to home, and the tendency to come back to their mother (or motherland) point to the singers’ emotions about their homeland. The distance from home has changed the conceptualization of “home.” The borders of home are not around the songwriters’ houses or intimate families anymore, but they are around the homeland.
Attitudes of EFL Learners in Kuwait Toward Project-Based Approach
Authors: Alobaidan Aishah Sami
Published: January 2025

Investigating learners’ attitudes is highly relevant to the improvement of teaching strategies and educational outcomes. The current study attempts to examine the attitudes of female EFL learners in the College of Basic Education in Kuwait toward the integration of project-based learning (PBL) in their English courses. The data were collected quantitatively using a questionnaire designed for the purpose of the study. The participants completed the questionnaire after experiencing PBL for about two months in their compulsory general English courses. The results revealed clear positive attitudes of these learners toward this student-centered method. The participants of the study have reported improvements in their English language skills, self-confidence, motivation, collaborative skills, and planning. These results can be used to improve the quality of English teaching in Kuwait and encourage the integration of PBL in all English classes in Kuwait’s public educational institutions. It is hoped that by encouraging the adoption of these modern strategies, Kuwait can enhance 21st-century skills among the graduates of its institutions and prepare them to be active and productive in their future careers.
Analisis Pengelolaan Grey Literature Sebagai Sumber Referensi di Perpustakaan Universitas Bhinneka PGRI Tulungagung
Authors: Luvi luthfiyah  , Nurul Setyawati Handayani
Published: January 2025

ABSTRAK
Perpustakaan perguruan tinggi sebagai tempat penyedia informasi bagi civitas akademika dituntut untuk memudahkan pemustaka dalam memenuhi kebutuhan informasi. Perpustakaan yang memadai yaitu perpustakaan yang mampu mengelola seluruh sumber informasi atau seluruh koleksi yang tersedia diperpustakaan khususnya koleksi grey literature tugas akhir mahasiswa. Pengelolaan koleksi perpustakaan yang baik akan memudahkan pemustaka dalam menelusur sumber informasi yang dibutuhkan.Tujuan dilakukan penelitian ini untuk mengetahui pengelolaan grey literature tugas akhir mahasiswa di Perpustakaan Universitas Bhinneka PGRI Tulungagung. Metode penelitian yang digunakan pada penelitian ini yaitu deskriptif kualitatif berlokasi di perpustakaan UBHI Tulungagung, informan pada penelitian ini yaitu kepala unit perpustakaan dan pustakawan perpustakaan UBHI Tulungagung. Kesimpulan dari penelitian ini yaitu pengelolaan grey literature tugas akhir mahasiswa di perpustakaan UBHI Tulungagung terdiri dari kegiatan inventarisasi, klasifikasi, labelling, dan shelving. Kegiatan ini dilakukan dengan cukup baik akan tetapi tidak terdapat edukasi  maupun proses khusus dalam sarana temu kembali informasi koleksi grey literature tugas akhir mahasiswa oleh pemustaka. Selain hal tersebut tidak adanya nomor panggil (Call number ) pada koleksi grey literature membuat proses temu kembali relatif lebih lama. Sehingga hal tersebut membuat pemustaka kesulitan dalam menemukan kembali koleksi grey literature tugas akhir mahasiswa karena harus mencari koleksi yang dibutuhkan satu persatu. Manfaat dari penelitian ini dapat memberikan pengetahuan terkait pengelolaan grey literature dan hasil penelitian dapat dijadikan evaluasi untuk memperbaiki dan memaksimalkan kualitas perpustakaan terkait pengelolaan grey literatutre tugas akhir.
 
Kata Kunci: Grey literature; Pengelolaan perpustakaan; Sumber referensi
Pengaruh Konten Youtube Short Terhadap Minat Baca Siswa Kelas 6 SD Negeri di Kecamatan Penajam Kabupaten Penajam Paser Utara
Authors: Adnan Andre Chairul , Suryanto  , Majidah
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh konten YouTube Short pada sosial media YouTube terhadap minat baca siswa kelas 6 SD Negeri di Kecamatan Penajam Kabupaten Penajam Paser Utara. Penelitian ini menggunakan metode kuantitatif deskriptif dengan subjek penelitian sebanyak 60 siswa kelas 6 SD Negeri di Kecamatan Penajam. Teknik pengumpulan data yang digunakan adalah kuesioner Sampel penelitian terdiri dari 60 siswa kelas 6 SD Negeri kelas 6 Kecamatan Penajam dam terbagi menjadi dua kelompok, yaitu kelompok eksperimen yang menonton konten YouTube Short selama satu minggu dan kelompok kontrol yang tidak menonton konten YouTube Short. Minat baca siswa kelas 6 SD Negeri Kecamatan diukur menggunakan skala Likert yang terdiri dari 10 pernyataan. Data yang diperoleh nantinya dianalisis menggunakan teknik analisis deskriptif dan inferensial. Analisis deskriptif digunakan untuk menggambarkan karakteristik subjek penelitian dan hasil pengukuran variabel penelitian. Sedangkan analisis inferensial digunakan untuk menguji hipotesis penelitian dengan menggunakan uji regresi linier sederhana. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara minat baca siswa yang menonton konten YouTube Short dengan tidak menonton. Nilai rata-rata minat baca siswa yang menonton konten YouTube Short adalah 4,2, sedangkan nilai rata-rata minat baca siswa yang tidak menonton konten YouTube Short adalah 3,6. Nilai t hitung adalah 2,54, yang lebih besar dari nilai t tabel pada taraf signifikansi 0,05 dengan derajat kebebasan 58, yaitu 2,00. Nilai p-value adalah 0,014, yang lebih kecil dari 0,05. Hal ini berarti hipotesis penelitian yang menyatakan bahwa ada pengaruh positif konten YouTube Short terhadap minat baca siswa diterima. Konten YouTube Short dapat menjadi salah satu media yang meningkatkan minat baca siswa kelas 6 SD Negeri kecamatan Penajam Kabupaten Penajam Paser Utara. Oleh karena itu, konten YouTube Short dapat menjadi alternatif yang dapat digunakan oleh guru dan orang tua untuk meningkatkan minat baca siswa.
Diagnostic Challenge in the Differential Diagnosis of Recurrent Seizures During Pregnancy: Epilepsy Versus Eclampsia
Authors: Andri Subiantoro  , Sugiharto Wahyu , Khaidar Reyfal
Published: January 2025

Introduction: Seizures during pregnancy are associated with adverse outcomes for mothers and infants. Seizures during pregnancy can be associated with multiple factors. To establish effective treatment and management of seizures, it is important to identify all of the factors that may contribute to seizures during pregnancy. Objective: This study aimed to evaluate and identify the cause of seizures in pregnancy to facilitate appropriate treatment. Case Report: We present a case of a 32-week pregnant woman who experienced eclampsia and recurrent seizures during the peripartum period. The patient had a history of inadequately managed epilepsy. Seizure management required multiple medications, including magnesium sulfate, benzodiazepine, and phenytoin. The patient underwent an emergency caesarean utilizing the Rapid Sequence Intubation (RSI) procedure and general anesthesia to rescue the baby. Nicardipine, furosemide, isosorbide dinitrate, captopril, spironolactone, and hydrochlorothiazide were used to manage blood pressure. The patient needs to be continuously observed, and the therapy should be adjusted according to the patient’s condition. Discussion: The patient had a history of epilepsy and had experienced two bouts of generalized seizures with characteristics of eclampsia before being arrived at the emergency room. Determining how to control the seizures in this spesific individual was a challenge. The primary therapy of patients with active seizures should include maintaining the airway, respiration, and circulation. The therapeutic objectives are immediate delivery of a viable fetus and maintenance of maternal health. Perioperative management aims to control blood pressure and seizures, maintain hemodynamics, manage anesthesia for terminating a pregnancy, and support critical care management for any potentially fatal complications from this condition. Conclusion: Seizures in pregnancy are attributable not just to eclampsia but can also cause by another or concurrently together with other causes. Early diagnosis and appropriate treatment are required to achieve the best outcome for this patient.
Mathematical forms of Planck’s thermal radiation law and photobiological biomass adaptations
Authors: Sendova Mariana , Moncada-Almendarez Isaac
Published: January 2025

Solar photons with energies from 1.2 to 3 eV fuel Earth’s biosphere via excited-state photochemical reactions. The solar radiance spectrum is successfully modeled by Planck’s thermal radiation law, applied to a blackbody heated to ~5,800 K. Mathematically, Planck’s thermal radiation law can be described by four distinct, bell-shaped radiance probability density functions. This study attempts to answer the question: Which one of the four distinct radiance spectral functions, representing one and the same thermal radiation law, is synergistic with the established photobiological adaptations on Earth? A well-defined quantitative criterion is proposed to select one of the four functions. The data suggest that the photon radiance per wavelength increment provides a deeper biophysical understanding of the broad range of photobiological biomass adaptations on Earth.
Study on the behavior of cane wood fiber–reinforced polymer composites for application in design
Authors: Anayo Agbo Cornelius Ogbodo
Published: January 2025

The growing need for sustainable green products and green manufacturing has broadened the search for high-quality natural fibers to reinforce polymer composites. However, as composites continue to serve as a viable alternative to metals in many engineering designs, the proper evaluation of these materials’ suitability is essential to aid in predicting the in situ manufacturing possibilities and in-service conditions. Cane wood fiber–reinforced composites are characterized in this study using notable mechanical tests, including tensile, compression, flexural, and impact tests. Test samples were produced with various cane wood fiber compositions of 15%, 30%, and 50% by volume fiber content. Comparative data from the samples were generated to assess their strength and behavior. The results obtained showed that cane wood fiber–reinforced polyester resin achieved a maximum tensile strength of 9.58 N/mm2 at 15% by volume fiber content, exhibiting a brittle behavior. The maximum energy to break of 4.68 J and the maximum impact strength of 0.78 N/mm2 were obtained at 30% by volume fiber content. It is, therefore, evident that while the 15% volume fiber content is structurally more suitable, the 30% volume fiber content offers better impact and damping characteristics, making it more appropriate for upholstery works and interior trim parts.
Adaptive Robot Navigation Using Randomized Goal Selection with Twin Delayed Deep Deterministic Policy Gradient
Authors: Ali Romisaa , Dogru Sedat , Marques Lino , Chiaberge Marcello
Published: January 2025

The primary challenge in robotic navigation lies in enabling robots to adapt effectively to new, unseen environments. Addressing this gap, this paper enhances the Twin Delayed Deep Deterministic Policy Gradient (TD3) model's adaptability by introducing randomized start and goal points. This approach aims to overcome the limitations of fixed goal points used in prior research, allowing the robot to navigate more effectively through unpredictable scenarios. This proposed extension was evaluated in unseen environments to validate the enhanced adaptability and performance of the TD3 model. The experimental results highlight improved flexibility and robustness in the robot's navigation capabilities, demonstrating the model's ability to generalize effectively to unseen environments. In addition, In addition, this paper presents a streamlined overview of the TD3 algorithm, focusing on its core mechanisms and improvements, to clarify its application in achieving enhanced adaptability and performance.
Three Mandatory Doses of Acetaminophen During the First Months of Life with the MenB Vaccine: A Protocol for the Induction of Autism Spectrum Disorder in Susceptible Individuals
Authors: Jones John , Konsoula Zacharoula , Williamson Lauren , Anderson Rachel , Meza-Keuthen Susanne , Parker William
Published: January 2025

The connection between acetaminophen use in the pediatric population and the etiology of autism spectrum disorder (ASD) have been a subject of misunderstanding, miscalculation, and misinformation for more than a decade. This narrative review summarizes 27 lines of evidence pointing with no reasonable doubt to the conclusion that exposure of susceptible babies and children to acetaminophen is responsible for many if not most cases of ASD. Susceptibility to acetaminophen-induced injury is imposed by a range of environmental, genetic, and epigenetic factors associated with oxidative stress, and is apparently the greatest immediately after birth. Susceptibility then decreases until about six years of age, which is likely outside of the developmental window in which regression into ASD can occur. Exposure to acetaminophen very early in life can occur for a variety of reasons, including treatment of pain during administration to the mother during labor and delivery, during vaccination, and during circumcision. Although acetaminophen use during vaccination is generally not recommended, the vaccine against meningococcal serogroup B (MenB), administered at 2, 4, and 12 months of life, is now recommended with 3 accompanying doses of acetaminophen in some countries with dramatically rising levels of ASD. Unfortunately, based on current knowledge, it is expected that such exposures to acetaminophen will induce ASD in some susceptible individuals. Evidence therefore strongly and unequivocally indicates that medical recommendations should mandate the MenB vaccine be given separately from other vaccines and without acetaminophen, which some national healthcare services (e.g., Australian and Canadian) have already identified as an acceptable clinical approach.