bluuebunny/crossref_metadata_2025 huggingface dataset:
Male antiphonal calls and phonotaxis evoked by female courtship calls in the large odorous frog (Odorrana graminea)
Authors: Shen Jun-xian
Published: March 2022

Acoustic communication plays a vital role in frog reproduction. In most anuran species, long-distance sound communication is one-way- from males to females; during the reproductive season males produce species-specific advertisement calls to attract gravid females, and females are generally silent but perform phonotactic movements that lead to amplexus. One exception is the concave-eared torrent frog (Odorrana tormota). In this species, females produce courtship calls that elicit antiphonal vocalizations by males, followed by precise phonotactic movements. The large odorous frog O. graminea in southern China, is subject to the same environmental constraints as O. tormota with which it is sympatric; it is unclear whether their sound communication is one-way or bidirectional. Here we provide the first data on female O. graminea vocalizations and their functions. Using playbacks of female calls, we conducted acoustic behavioural experiments in the laboratory in response to which males emitted single- or multi-note antiphonal calls with a varying fundamental frequency. Moreover, they were attracted to female call playbacks, exhibiting precise phonotaxis. The female courtship call ̶ male response interaction thus forms a duet between partners of a receptive pair. These results demonstrate that this unique communication system likely reflects an adaptation to an environment in which short-distance communication is at a premium given the high levels of ambient noise.
Anastylosis of Apsidal Roof Engineering for Ecclesiae of Hawrān during Late Antiquity: Case of Julianos Church in Umm el-Jimal, Jordan
Authors: Rabady Rama Al , Rababeh Shaher
Published: March 2022

Umm el-Jimal, located in Hawrān of Late Antiquity, is well-known for the use of volcanic-based building materials; mainly basalt stone and scoria. Structural attributes of these two materials are important for examining potential roofing system(s) that could have been used for the semi-circular apse of Julianos Church in Umm el-Jimal. Since the roof is demolished nowadays, the study examines two interpretive theories presented in literature: ‘vault roof’ as put forward by Professor Howard Butler in 1913 and ‘corbelled flat roof’ as suggested by Corbett and Reynolds in 1957. A third theory is also introduced in this study, based on available archaeological remains, relevant cases, and religious and scientific premises. It advocates a ‘composite system’ of corbelled relieving diaphragms and non-load-bearing vaulted structure to generate a box-like buttressing apse. The composite system can operate interactively to resist static loads and dynamic seismic forces. Builders of Hawrān should have introduced novel engineering of their ecclesiastical architecture that differs from its ‘classical’ counterpart. Contemporary conservators can respectively consider these theories in their attempts to salvage the alarmingly vanishing ecclesiae of Hawrān.
Estimating the Risk of SARS-CoV-2 Deaths Using a Markov Switching-Volatility Model Combined with Heavy-Tailed Distributions for South Africa
Authors: Mthethwa Nobuhle , Chifurira Retius , Chinhamu Knowledge
Published: March 2022

Background: SARS-CoV-2 (Covid-19 virus) infection exposed the unpreparedness of African countries to health-related issues, South Africa included. Africa recorded more than 211 853 deaths as a consequence of Covid-19. South Africa faced the highest number of casualties. This study aimed to estimate the risk of fatalities due to Covid-19 infection for an African country hard hit by the pandemic. The value-at-risk (VaR) concept in financial time series analysis is used to estimate the risk of deaths.Methods: In this study, the daily number of deaths due to Covid-19 infection is used. Exploratory data analysis reveals that the data exhibits non-normality, three structural breaks and volatility clustering characteristics. The Markov switching (MS)-generalized autoregressive conditional heteroscedasticity (GARCH)-type model combined with heavy-tailed distributions is fitted to the returns of the data. The heavy-tailed distributions employed are the Student-t distribution (StD), Skewed Student-t distribution (SStD), normal reciprocal inverse Gaussian distribution (NRIGD), and Pearson type IV distribution (PIVD). Risk estimates were estimated using the value-at-risk (VaR) procedure. The model performances were assessed using the Kupiec likelihood ratio test.Results: The results indicate that the MS(3)-GARCH(1,1)-NRIGD is the best model at 90%. At 95% the MS(3)-GARCH(1,1)-SStD and MS(3)-GARCH(1,1)-PIVD are the best models, and MS(3)-GARCH(1,1)-StD, MS(3)-GARCH(1,1)-NRIGD, MS(3)-GARCH(1,1)-PIVD are the best at 97.5%. The MS(3)-GARCH(1,1)-NRIGD is the best model at 99%. Overall MS(3)-GARCH(1,1)-NRIGD is the best model, it outperforms all the models at almost all the levels. VaR estimates indicated that with a probability of 0.95, the number of deaths that will occur on the 27th, 28th and 29th of August 2021 will be greater than 278, 211, and 134 respectively, the actual values are 361, 274 and 134.Conclusion: The MS(3)-GARCH(1,1) model combined with heavy-tailed distributions provides a robust model for estimating the risk of death due to Covid-19. The accuracy of the volatility model is essential in forecasting the volatility of future health-related deaths in which the predictability of volatility plays an integral role in health risk management.
The Effect of Pupil Dilation on Biometry Measurements Obtained by AL-Scan in the Cataractous Eyes
Authors: Üçer Mehmet Barış , Bozkurt Erdinç , Gökmen Hülya
Published: March 2022

Purpose
To evaluate the effect of cycloplegia on the biometric parameters and intraocular lens (IOL) power calculated by Sanders–Retzlaff–Kraff/theoretical (SRK/T) formula in the cataractous eyes.
Methods
This cross-sectional study included 68 senile cataractous eyes of 68 patients who were scheduled to undergo cataract surgery. Measurements of anterior chamber depth (ACD), axial length (AL), white to white (WtW) diameter, corneal power (K1, K2, Kmean), central corneal thickness (CCT), and pupil size (PS) were obtained with AL-Scan (Nidek Co., Ltd, Gamagori, Japan) before and after cycloplegia. The SRK/T formula was used to calculate IOL power with a target refraction of 0 D. Cycloplegia induced by cyclopentolate hydrochloride %1.
Results
The mean age of the patients was 70.60 ± 4.07 years (range 65 to 80). A significant increase was observed in ACD after cyloplegia (p < 0.001). There was not any statistically significant difference between pre-dilation and post-dilation AL, WtW, CCT, K1, K2, Kmean and IOL power readings (p > 0.05). A decrease above 0.5 D was observed after cycloplegia in two cases.
Conclusion
Cycloplegia induced by cyclopentolate hydrochloride %1 does not affect the measurement of the AL, WTW, CCT, keratometry and SRK/T calculated IOL power with the exception of ACD in cataractous eyes with AL-Scan.
Tidal power station at sea
Authors: Huang Junqiang
Published: March 2022

Tidal energy is a cleaning resource made by the moon, it is one of the best ways for human beings to save the earth from the devastating consequences of global warming.Now climate change is a big problem to us, we should look for some good green energy to prevent global warming, we should work hard to preserve our planet. If not so, no one knows how long human beings can survive on this planet. Tidal flow speed is very big in some places, for example, at the ocean strait;also some entrances of semi-enclosed sea bays. It involves large energy,we can calculate it.According to Newton second law theory ΣF = ma, we can get the momentum theorem ΣFdt = mdv. According to dv, we can calculate the tidal flow force ΣF, then we can calculate how much energy we can get. Tide comes and goes every day, we can use tidal flow to generate electric power, then we can reduce coal power stations to cut down pollution to prevent global warming, it is a good reason to start tidal power stations.We can build a device like Fig. (1) in the following, and the surface area of square vane is one square meter. After calculation,we get the power of this device 235.7 (W). When enlarging both length and width into 2 meters,we get the power of this device nearly 13.2(KW) .Although it is little energy, we make sure we can get green energy from the ocean; we can make it bigger to get more power.We should do it, we must prevent global warming,we must preserve our earth,otherwise human beings will die out.
Physico-Analytical Studies on some Heterocyclic Azo Dyes and their Metal Complexes with some Transition Metals
Authors: El-Seify F. A. , Azab Hassan A. , Degedy Fikrea S. , Abdel-Mageed Khalid A. , El-Dossoki F. I.
Published: March 2022

In this investigation the azo dyes prepared through diazotizing 3-phenyl-5-aminopyrazole (PAP) and coupling the resulting diazonium salt with Schäffer acid [2-(3‛-phenyl-5‛-pyrazolyl azo) Schäffer acid (la)] and resorcinol [2-(3‛-phenyl-5‛ -pyrazolyl azo) resorcinol (Ib)]. These compounds are used as chromogenic reagents for the spectrophotometric determination of copper, nickel, cobalt and zinc. The conditional acid dissociation constants of these azo dyes (la, Ib) and the stability constants of its metal ion complexes have been determined by spectroanalytical methods. The molar absorptivity and Sandell's sensitivity values of the complexes have been evaluated. The stability constants of the formed complexes have been determined. This will be the subject of future studies concerning the biotechnological applications of our results in the effort to obtain possible new anticancer drugs.
Air-containing space: significantly in predicting EGFR mutation for early lung adenocarcinoma appearing as subsolid nodule
Authors: Xue Xinying , Xie Mei , Gao Jie , Wu Chongchong , Zang Xuelei , Ma Xidong , Xie Yutong , Yao Jie , Shen Jing , Jiang Tianjiao , Wu Jianlin
Published: March 2022

Background: To demonstrate the interrelation between computed tomography (CT) characteristics and epidermal growth factor receptor (EGFR) mutation status in early-stage lung adenocarcinoma manifested as subsolid nodule.Method: A total of 202 patients with appearance as subsolid nodules on CT images and pathologically confirmed as early-stage lung adenocarcinoma were enrolled in this study. All of the patients divided in to EGFR mutation group and EGFR wild-type group. Correlation between clinical and radiological features and EGFR mutation status were analyzed with univariate and multivariate analysis. A receiver operating characteristic (ROC) curves were generated to evaluate the logistic regression model.Results: EGFR mutation were detected in 137 of 202 patients. In univariate analysis, female gender, non-smokers, larger tumor size, lobulation, air-containing space and pleural retraction were more commonly indicated in EGFR mutated tumors than in EGFR wild-type tumors. Multivariate logistic regression analysis revealed that smoking history (OR, 0.275; 95%CI, 0.090–0.840), tumor size (OR, 4.263; 95%CI, 1.802–9.982) and air-containing space (OR, 3.055; 95%CI, 1.266–7.372) were independent predicting factor relevant to EGFR mutation. The AUC of ROC curve for predicting model reached 0.808. In addition, air-containing space with EGFR mutations were more commonly less than 5mm, solitary and mainly in an eccentric distribution.Conclusion: Our research indicated that smoking history, tumor size and air-containing space were independent factor for predicting EGFR mutation in early-stage lung adenocarcinoma appeared as subsolid nodule. Solitary air-containing space with≤5mm and eccentric distribution would help to determine EGFR mutation status.
Brain-Derived Neurotrophic Factor Profile in Ischemic Heart Disease; a Systematic Review and Meta-Analysis
Authors: Shobeiri Parnian , Behnoush Amirhossein , Khalaji Amirmohammad , Rezaei Nima
Published: March 2022

Background
Patients with ischemic heart disease (IHD) are at high risk of ischemic heart events, and novel biomarkers that reflect the severity of atherosclerotic disease and the fragility of coronary plaques are warranted. The Brain-Derived Neurotrophic Factor (BDNF) regulates endothelial and macrophage activation, suggesting a role in atherosclerotic plaque behavior. However, the precise involvement of BDNF in cardiovascular events is still unknown. This is the major goal of this study.
Method
We explored four databases for studies comparing BDNF levels in patients with IHD and controls. The Newcastle-Ottawa scale was used to evaluate the quality of included articles, and statistical analyses were conducted using R version 4.0.4.
Results
The final analysis comprised nine investigations covering 1,137 IHD patients and 724 controls. The preliminary result revealed statistically insignificant lower levels of BDNF in IHD compared with controls (SMD = -0.57, 95% CI [-1.18; 0.04], p-value = 0.068). After removing outliers, the following statistically significant results were obtained: SMD − 0.41 (95% CI [-0.78; -0.03], p-value = 0.03). In addition, subgroup analysis demonstrated no significant difference between serum and plasma levels (p-value = 0.53). No predictor for the difference in BDNF levels was revealed using meta-regression.
Conclusion
To conclude, when outlier studies were excluded, serum and plasma BDNF concentrations were considerably lower in patients with IHD than in healthy controls. Further studies of higher quality are required to investigate the function and value of BDNF in IHD.
Cost-effectiveness analysis of gender transition medical interventions in Sweden
Authors: Kirey-Sitnikova Yana , Ahmed Sayem
Published: March 2022

Purpose: Insurance coverage of gender transition medical interventions (GTMI), including hormone-replacement therapy and sex-reassignment surgeries, is a contested topic around the globe. However, a limited number of studies performed a cost-effectiveness analysis (CEA), necessitating more research in this area.Methods: Following a systematic review, two epidemiological studies — one for trans women (vaginoplasty) in Sweden, another for trans men (mastectomy and hysterectomy) in Iran — were identified as suitable for CEA. Improvement in health-related quality of life (HRQoL), demonstrated in these studies, was used to calculate quality-adjusted life years (QALY). Costs for the Swedish healthcare system were taken from literature. A simple decision tree model and sensitivity analysis with Monte Carlo simulation were used to determine cost-effectiveness.Results: Surgeries for trans men were found to be cost-effective in a Swedish healthcare perspective, while surgeries for trans women were on the verge of being not cost-effective. The lack of accurate data made it impossible to calculate indirect effects of surgeries on outcomes such as risk of HIV, depression, drug abuse, and suicide attempts.Conclusion: The present study demonstrates a significant gap in the epidemiological research on GTMI and suggests directions for improvement.
Dual-targeting micelles with ROS-sensitive H2S donor based on Sialic acid and Chondroitin sulfate for atherosclerosis
Authors: Chen Daquan , Chen Qiang , Guo Chunjing , Zhou Xiudi , Su Yanguo , Guo Huimin , Cao Min , Li Jing , Zhang Yue , Zhao Weiyi , Gao Xin , Mi Shuqi
Published: March 2022

Background: Currently, very limited therapeutic approaches are available for the drug treatment of atherosclerosis(AS). H2S-donor is becoming a common trend in much life-threatening research. Several studies have documented that H2S-lyase is predominantly present in endothelial cells. Sialic acid, natural carbohydrate, binds specifically to the E-selectin receptor of endothelial cells. Meanwhile, Recent studies related to Chondroitin sulfate have excellent target binding ability with CD44 receptor. We conjecture that the dual targeting of chondroitin sulfate and Sialic acid not only enhances the accumulation of the drug in the lesion but also cleaves the H2S donor, thus one stone two birds. Methods: Given these findings, we synthesized two kinds of nanoparticles, Carrier I (SCCF) and Carrier II (SCTM), for atherosclerosis to validate our guesses. Initially, S-allyl-L-cysteine and 4-methoxyphenylthiourea were used as H2S donors for SCCF and SCTM, respectively. After the introduction of ROS-sensitive groups. Then, chondroitin sulfate as the modified matrix and Sialic acid as the targeting group, micelles were prepared to load rapamycin(RAP). Results: In the in vitro assay, micelles were significantly different under H2O2 (1 mM) conditions. In the targeting test, the dual-target effect was superior to the other subgroups. treatment with SCCF@RAP and SCTM@RAP effect in AS is remarkable as confirmed via Oil Red O staining. Conclusions: Thus, we conclude that the effect of dual targeting nanomicelles with ROS-sensitive H2S donor will have a better role in atherosclerosis.
BNPs@SiO2(CH2)3 -TAPC-O-(CH2)2NH2-Pd (0) as a Nanocatalyst for the Coupling Reactions and Removing of Organic Dyes
Authors: Khodamorady Minoo , Jafarzadeh Mohammad , Bahrami Kiumars.
Published: March 2022

BNPs@SiO2(CH2)3-TAPC-O-(CH2)2NH2-Pd (0) as a highly sustainable, renewable and effectual heterogeneous nano-catalyst is used for C-C cross coupling reactions and removal of cationic (Methylen Blue) and anionic (Methyl Orange) organic dyes from aqueous medium. This nano-catalyst has features such as high activity, low cost, excellent stability, recoverability for six consecutive times with little loss in catalytic power.
Environmental Policy paradigm shifts in the post-1990 period in India
Authors: SHARMA JAGMOHAN
Published: March 2022

The post-1990 period continues to witness focus on addressing environmental pollution, conservation of biological diversity, restoration of natural ecosystems, and sustainable development. For India, it is further contextualized by the launch of the economic liberalization process in 1991, as it unleashed a severe contestation between economic activity and environmental conservation needs. From the literature, five environmental policy paradigm shifts are apparent in the post-1990 period in India: a) right to a clean environment as a fundamental right; b) polluter accountable for pollution; c) prevention approach to pollution; d) intergenerational considerations in environmental decision-making; and e) consultations-based approach to decision making. Results of the questionnaire-based survey reveal that a predominant majority of experts agrees on the abovementioned policy paradigm shifts. Such agreements range between 68% for ‘intergenerational consideration in decision-making’ to 93% for ‘right to clean environment’. Among the drivers of change, court judgments and civil society groups are the most influential drivers followed by the agency of international conventions, industrial accidents, constitutional amendments, and externally aided projects.
Metabolic Disorders in Long-Living Patients with Coronary Artery Disease
Authors: Topolyanskaya Svetlana , Eliseeva Tatyana A. , Balyasnikova Natalya A. , Sanina Anna I. , Vakulenko Olga N. , Dvoretski Leonid I.
Published: March 2022

Background/Objective Very limited data are available on metabolic disorders in centenarians; therefore, we investigated these pathologies in long-living patients with coronary artery disease (CAD). Methods The study enrolled 225 patients > 90 years, hospitalized with CAD diagnosis. The majority of patients (67.6%) were women. The mean age of patients was 92.5 ( + 2.2) years. Blood levels of uric acid, lipids, glucose and body mass index were determined. Results Obesity was registered in 31.5% of patients, but grade III obesity – in 1 patient. Overweight was found in 39.1% of patients, normal BMI – in 28.9%, and underweight – in 1 patient. Increase in the blood concentration of triglycerides was noted in 11.2% of patients. Decrease in the HDL cholesterol level was registered in 12.7% of patients. Blood concentration of LDL cholesterol < 2.0 mmol / l was observed in 23.3% of cases. Hyperuricemia was detected in 37.3% of patients – in 41.4% of women and 28.8% of men. Increase in the serum creatinine level was registered in 45% of patients. Only 16.5% of patients had glomerular filtration rate > 60 ml/min. Women had more frequent hyperuricemia, dyslipidemia and azotemia. Increase in fasting blood glucose level was found in 23.1% of patients, but only 0.9% of patients had glucose >14 mmol/l. Conclusions Study results indicate some clinical features of metabolic disorders in long-living patients with coronary artery disease. High proportion of patients with overweight or obesity was found. Frequent hyperuricemia but relatively low levels of atherogenic lipids and glucose were registered.
Digital Haptics Improve Speed of Visual Search Performance in a Dual-Task Setting
Authors: Tivadar Ruxandra I. , Arnold Rebecca C. , Turoman Nora , Knebel Jean-François , Murray Micah M.
Published: March 2022

Dashboard-mounted touchscreen tablets are now common in vehicles. Screen/phone use in cars likely shifts drivers’ attention away from the road and contributes to risk of accidents. Nevertheless, vision is subject to multisensory influences from other senses. Haptics may help maintain or even increase visual attention to the road, while still allowing for reliable dashboard control. Here, we provide a proof-of-concept for the effectiveness of digital haptic technologies (hereafter digital haptics), which use ultrasonic vibrations on a tablet screen to render haptic perceptions. Healthy human participants (N = 25) completed a divided-attention paradigm. The primary task was a centrally-presented visual conjunction search task, and the secondary task entailed control of laterally-presented sliders on the tablet. Sliders were vertical, horizontal or circular and were presented visually, haptically, or visuo-haptically. We reasoned that the primary task would be performed best when the secondary task was haptic-only. Reaction times (RTs) on the visual search task were fastest when the tablet task was haptic-only. This was not due to a speed-accuracy trade-off. While precision with the tablet task was lowest when haptic-only, such can likely be readily trained. These results provide the first quantitative support for introducing digital haptics into vehicle and similar contexts.
Is Schistosomiasis a Red Herring in Carcinoma of the Bladder?
Authors: Sanusi Haruna Muhammad , Taoheed Atanda Akinfenwa
Published: March 2022

Objective: The specific role Schistosoma ova play in bladder carcinogenesis as well as its association with a specific morphologic subtype has remained inconclusive. This study aims to re-evaluate this relationship morphologically and review the literature.

Materials: A 19-year (1999-2017) review of all cases of carcinoma of the bladder with or without schistosomiasis was conducted. This was supplemented with a review of the literature.

Results: 278 cases of carcinoma of the bladder were diagnosed. These comprised 251 males and 27 females in ratio 9:1 and mean ages 56±15 years and 54±16 years respectively (p 0.6).  While none of the 27 carcinomas among females had Schistosoma ova 28 of the 251 carcinomas in males were co-morbid with schistosomiasis. These comprised 13 of the 174 TCC, 14 of the 94 SCC, and 1 of the 10 adenocarcinomas. There were no statistically significant differences in gender (p 0.6), age (p 0.6), or co-morbidity with the parasite (p 0.2) among the various histologic subtypes. A review of the literature shows an association of Schistosoma ova not only with SCC but also with TCC and, but for isolated case reports, there is a paucity of definitive association with cancers outside the bladder.

Conclusion: There were no statistically significant differences in gender, age, or co-morbidity with the parasite among the various histologic subtypes. In addition to this, the literature review suggests there must be other co-factors present only in the bladder, rather than just the ova by itself, responsible for Schistosoma-associated carcinoma in this organ.
El Digital Storytelling como herramienta educativa de desarrollo de la creatividad. Un estudio de caso en una cuna jardín peruana
Authors: Hurtado-Mazeyra Alejandra , Afata-Ataucuri Katherine Eudis , Ancasi-Villagomez Gianella Solange , Núñez-Pacheco Rosa
Published: March 2022

El Digital Storytelling (DST) es una herramienta digital que sirve para desarrollar la creatividad y potenciar las habilidades narrativas en los estudiantes de diferentes niveles educativos. Se realizó una investigación de enfoque cuantitativo de tipo preexperimental en una cuna jardín en Perú con el objetivo central de comprobar la mejora de la creatividad después de la experiencia con la herramienta DST. Participaron 70 niños de 5 y 6 años utilizando la herramienta Sumaq Willakuy (Cuento bonito), un software diseñado para la creación de narrativas digitales para niños de educación infantil. El instrumento aplicado en el estudio es el TCI (Test de creatividad infantil). Los resultados indicaron que existen diferencias significativas entre el pretest y el postest en el puntaje global de la creatividad infantil (PD), especialmente en las variables proceso o producto (PDB) y figuras añadidas (PDC). No se encontraron diferencias significativas en función a la edad y el sexo. Se concluye que el uso del DST ha mejorado la capacidad creativa de los niños. En tal sentido, el DST puede ser aplicada en otros contextos similares para desarrollar la creatividad infantil.

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Editorial - Turismo Religioso em Tempos de Pandemia
Authors: Monteiro de Oliveira Christian Dennys
Published: March 2022

Apresentação dos artigos do numéro temático sobre Turismo Religioso em Tempos de Pandemia.
The Role of Alternative Toxicological Trials in Drug Discovery Programs.
The Case of Caenorhabditis elegans and Other Methods
Authors: Göethel Gabriela , Augsten Lucas Volnei , das Neves Gustavo Machado , Gonçalves Itamar Luís , de Souza João Pedro Silveira , Garcia Solange Cristina , Eifler-Lima Vera Lucia
Published: March 2022

The discovery of a new drug requires over a billion dollars and around 12
years of research efforts, and toxicity is the leading reason for the failure to approve candidate
drugs. Many alternative methods have been validated to detect toxicity as early as
possible to diminish the waste of resources and efforts in medicinal chemistry research,
and in vivo alternative methods are especially valuable for the amount of information
they can provide at little cost and in a short time. In this work, we present a review of the
literature published between the years 2000 and 2021 on in vivo alternative methods of
toxicity screening employed in medicinal chemistry, which we believe will be useful because,
in addition to shortening the research time, these studies provide much additional
information aside from the toxicity of drug candidate compounds. These in vivo models
include zebrafish, Artemia salina, Galleria mellonella, Drosophila melanogaster, planarians,
and Caenorhabditis elegans. The most published ones in the last decade were zebrafish,
D. melanogaster, and C. elegans due to their reliability, ease, and cost-effectiveness
in implementation and flexibility. Special attention is given to C. elegans because of
its rising popularity, a wide range of uses, including toxicity screening, and active effects
measurement, from antioxidant effects to anthelmintic and antimicrobial activities, and
its fast and reliable results. Over time, C. elegans also became a viable high-throughput
(HTS) automated drug screening option. Additionally, this manuscript lists briefly the
other screening methods used for the initial toxicological analyses and the role of alternative
in vivo methods in these scenarios, classifying them as in silico, in vitro and alternative
in vivo models that have been receiving a growing increase in interest in recent
years.
Advancement and Applications of Platelet-inspired Nanoparticles:
A Paradigm for Cancer Targeting
Authors: Swain Suryakanta , Ghose Debashish , Patra Chinam Niranjan , Jena Bikash Ranjan , Rao Muddana Eswara Bhanoji
Published: March 2022

Platelet-inspired nanoparticles have ignited the possibility of new opportunities for producing
similar biological particulates, such as structural cellular and vesicular components, as well
as various viral forms, to improve biocompatible features that could improve the nature of biocompatible
elements and enhance therapeutic efficacy. The simplicity and more effortless adaptability of
such biomimetic techniques uplift the delivery of the carriers laden with cellular structures, which
has created varied opportunities and scope of merits like; prolongation in circulation and alleviating
immunogenicity improvement of the site-specific active targeting. Platelet-inspired nanoparticles or
medicines are the most recent nanotechnology-based drug targeting systems used mainly to treat
blood-related disorders, tumors, and cancer. The present review encompasses the current approach of
platelet-inspired nanoparticles or medicines that have boosted the scientific community from versatile
fields to advance biomedical sciences. Surprisingly, this knowledge has streamlined to development
of newer diagnostic methods, imaging techniques, and novel nanocarriers, which might further
help in the treatment protocol of the various diseased conditions. The review primarily focuses on
the novel advancements and recent patents in nanoscience and nanomedicine that could be streamlined
in the future for the management of progressive cancers and tumor targeting. Rigorous technological
advancements like biomimetic stem cells, pH-sensitive drug delivery of nanoparticles, DNA
origami devices, virosomes, nano cells like exosomes mimicking nanovesicles, DNA nanorobots,
microbots, etc., can be implemented effectively for target-specific drug delivery.
The Synthesis and Application of Ionic Liquid Functionalized Mesoporous
Silica SBA-15 for Organic Synthesis
Authors: Ziarani Ghodsi Mohammadi , Javadi Fatemeh , Mohajer Fatemeh , Badiei Alireza
Published: March 2022

Ionic liquid functionalized mesoporous silica compounds present significant advantages
in organic synthesis as catalysts. There are various preparation procedures for the
synthesis of diverse ionic liquid catalysts, which have different catalytic properties with various
roles in organic reactions. Therefore, due to the increment in the usage of mesoporous
materials in the industry and numerous pieces of research, in this article, the information on
the development of ionic liquids supported on SBA-15 between the years 2014 and 2021 was
gathered.
Rheumatoid Arthritis and JAK-STAT Inhibitors: Prospects of Topical Delivery
Authors: Nishal Suchitra , Jhawat Vikas , Phaugat Parmita , Dutt Rohit
Published: March 2022

Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical prospects have increased tremendously since the advent of biological agents as therapy options. NSAIDs such as indomethacin, celecoxib, and etoricoxib are used often in the treatment of RA but off-target effects decreased their use. DMARDs such as methotrexate and etanercept were also effective in the treatment of RA, but tolerance to methotrexate developed in many cases. Janus kinase inhibitors (JAKi) have also gained popularity as a treatment option for rheumatoid arthritis. Tofacitinib is the foremost JAK inhibitor that is used to treat RA as an individual agent or in combination with other DMARDs. The most frequently used route of administration for JAKi is oral. Since oral formulations of JAK inhibitors have a number of health hazards, such as systemic toxicity and patient noncompliance, topical formulations of JAK inhibitors have emerged as a preferable alternative for administering JAK inhibitors. Tofacitinib delivered topically, seems to have the potential to eliminate or reduce the occurrences of negative effects when compared to tofacitinib taken orally. Given the scarcity of knowledge on the techniques for topical distribution of JAKi, more effort will be required to develop a stable topical formulation of JAKi to address the limitations of oral route. The current review looks at JAK inhibitors and the ways that have been used to generate topical formulations of them.
Cardiovascular disorders in patients with Zika Virus: integrative review
Authors: Rezende Lucas Dalvi Armond , Freitas Paula de Souza Silva , Catabriga Davi de Souza , Mocelin Helaine Jacinta Salvador , De Jesus Silva Kelly Eduarda , Moreira Silva Lavinya , Fiorin Bruno Henrique
Published: March 2022

Objective: To describe the primary cardiovascular disorders manifested in patients infected with the zika virus and understand the pathophysiological process. Methods: This integrative literature review occurred in January 2021 through the PICO strategy, which answered the guiding question: “What are the main cardiovascular disorders manifested in patients infected with zika virus?” For this, a time interval of 5 years was defined, using the descriptors “Zika Virus”,“Heart” and “Cardiovascular Diseases” in English, Portuguese and Spanish. The contemplated databases were MEDLINE, LILACS, and BDENF. Results: There were a total of 77,872 articles, of which, after the exclusion and inclusion processes, it was summarized in eight articles included in this review. The main cardiovascular findings present were apical muscular ventricular septal defect and ostium secundum, in addition to atrial fibrillation and heart failure with reduced ejection fraction. Conclusions: Further studies with more robustness that clearly establish the mechanism of cellular tropism for cardiac muscle cells and involve the pathophysiological process of cardiac alterations more clearly and reliably are needed.
II Congresso Mineiro de Enfermagem
Authors: II Congresso Mineiro de Enfermagem
Published: March 2022

O II Congresso Mineiro de Enfermagem foi realizado no período de 25 a 27 de novembro de 2021 no formato online, realizado pela Nova Faculdade. O Congresso objetivou também ampliar o saber da enfermagem de acadêmicos e profissionais de todo o Estado de Minas Gerais e tem como destaque a contextualização das perspectivas da profissão, através do tema central: Empoderamento e Autonomia da Enfermagem no Século XXI.
Profile structures for economical hybrid lightweight design
Authors: Wagner David , Löpitz David , Knobloch Marcus , Gedan-Smolka Michaela , Schubert Katrin
Published: March 2022

Especially in the transport sector, lightweight design with fiber reinforced plastics (FRP) is of major relevance due to CO2 reduction through mass saving [1]. In sectors like automotive, FRP are mainly used in secondary structures such as seat shells. In order to be able to operate effective FRP lightweight design in load-bearing structural components, pultruded hybrid profiles are to be established as a new tool for engineers. The profile components are characterized by a FRP base structure and a metallic core that increases the ductility. The manufacturing of the components with pultrusion ensures a large scale production. To guarantee a high covalent bond between the metal cores and the FRP, the inserts are provided by using a newly developed powder coating, which acts like a latent reactive adhesive [2]. Three different profile constructions have been verified, which are identical in the external cross-sectional shape and size, but differing in core structure. A glass-FRP-steel-combination was chosen as material and a pure FRP sample was used as a reference. The mechanical properties were investigated by using a 4-point bending test. Depending on the core structure, various failure behavior and mechanical parameters like energy absorption could be determined.
Smartphone Apps for Managing Antithrombotic Therapy: Scoping Literature Review
Authors: Praus Friederike , Krzowski Bartosz , Walther Tabea , Gratzke Christian , Balsam Paweł , Miernik Arkadiusz , Pohlmann Philippe Fabian
Published: March 2022

Background

Antithrombotic therapy is complex and requires informed decisions and high therapy adherence. Several mobile phone apps exist to either support physicians in the management of antithrombotic therapies or to educate and support patients. For the majority of these apps, both their medical evidence and their development background are unknown.

Objective

This review aims to investigate the available literature describing high-quality apps for managing antithrombotic therapy based on professional scientific information.

Methods

Keywords and Medical Subject Heading terms were used to search MEDLINE via PubMed and Ovid between December 2019 and January 2022. Inclusion criteria were the availability of full text and publications in the English language. Apps that solely focused on atrial fibrillation were excluded. Qualitative findings were thematically synthesized and reported narratively.

Results

Out of 149 identified records, 32 were classified as eligible. We identified four groups: (1) apps for patients supporting self-management of vitamin K antagonists, (2) apps for patients increasing therapy adherence, (3) educational apps for patients, and (4) apps for physicians in supporting guideline adherence.

Conclusions

Throughout the evaluated data, patients from all age groups receiving antithrombotic drugs expressed the desire for a digital tool that could support their therapy management. In addition, physicians using mobile guideline-based apps may have contributed to decreased adverse event rates among their patients. In general, digital apps encompassing both user-friendly designs and scientific backgrounds may enhance the safety of antithrombotic therapies. However, our evaluation did not identify any apps that addressed all antithrombotic drugs in combination with perioperative stratification strategies. Currently, strict regulations for smartphone apps seem to negatively affect the development of new apps. Therefore, new legal policies for medical digital apps are urgently needed.
Pilot Testing in the Wild: Feasibility, Acceptability, Usage Patterns, and Efficacy of an Integrated Web and Smartphone Platform for Bipolar II Disorder
Authors: Fletcher Kathryn , Lindblom Katrina , Seabrook Elizabeth , Foley Fiona , Murray Greg
Published: March 2022

Background

Bipolar II disorder (BD-II) is associated with significant burden, disability, and mortality; however, there continues to be a dearth of evidence-based psychological interventions for this condition. Technology-mediated interventions incorporating self-management have untapped potential to help meet this need as an adjunct to usual clinical care.

Objective

The objective of this pilot study is to assess the feasibility, acceptability, and clinical utility of a novel intervention for BD-II (Tailored Recovery-oriented Intervention for Bipolar II Experiences; TRIBE), in which mindfulness-based psychological content is delivered via an integrated web and smartphone platform. The focus of the study is evaluation of the dynamic use patterns emerging from ecological momentary assessment and intervention to assist the real-world application of mindfulness skills learned from web-delivered modules.

Methods

An open trial design using pretest and posttest assessments with nested qualitative evaluation was used. Individuals (aged 18-65 years) with a diagnosis of BD-II were recruited worldwide and invited to use a prototype of the TRIBE intervention over a 3-week period. Data were collected via web-based questionnaires and phone interviews at baseline and 3-week follow-up.

Results

A total of 25 participants completed baseline and follow-up assessments. Adherence rates (daily app use) were 65.6% across the 3-week study, with up to 88% (22/25) of participants using the app synergistically alongside the web-based program. Despite technical challenges with the prototype intervention (from user, hardware, and software standpoints), acceptability was adequate, and most participants rated the intervention positively in terms of concept (companion app with website: 19/25, 76%), content (19/25, 76%), and credibility and utility in supporting their management of bipolar disorder (17/25, 68%). Evaluation using behavioral archetypes identified important use pathways and a provisional model to inform platform refinement. As hypothesized, depression scores significantly decreased after the intervention (Montgomery-Asberg Depression Rating Scale baseline mean 8.60, SD 6.86, vs follow-up mean 6.16, SD 5.11; t24=2.63; P=.01; Cohen d=0.53, 95% CI 0.52-4.36).

Conclusions

Our findings suggest that TRIBE is feasible and represents an appropriate and acceptable self-management program for patients with BD-II. Preliminary efficacy results are promising and support full development of TRIBE informed by the present behavioral archetype analysis. Modifications suggested by the pilot study include increasing the duration of the intervention and increasing technical support.
Smart Women Protection System Using IOT
Authors: Preeti P , Tajammul Mohd
Published: March 2022

Abstract: Everyday every female irrespective of their age face lot of security issues while stepping out of the houses, in today’s world women’s safety has become one of the major problem Women have alwaysbeen vulnerable. Even with technology advancements, women are still unsafe anywhere. There are many places where they are vulnerable -including lonelyroads and abandoned places. In light of the current crime situation with women, a smart safety app based on the Internet of Things was suggested An IoT smart device that incorporates GPS, a panic button, a watch me button, and a web interface is used to provide the victim with her current location upon pressing a button.
Sino-Russian Cooperation in the Yangtze and Volga River Basins
Authors: Wang Juntao , Lyubina D. E.
Published: March 2022

Cooperation between the regions of the Volga Federal District and the territories of the upper and middle reaches of the Yangtze River of the People’s Republic of China is one of the tools for activating multifaceted Russian-Chinese relations. The creation of a Sino-Russian cooperation mechanism through the Volga — Yangtze Format is of great importance for promoting the development of economic and trade exchanges between the two states, as well as the formation of points of contact in the humanitarian sphere. The similarity of geographical features of these regions is a good basis for the exchange of experience in solving economic, environmental and humanitarian problems of the development of territories located along major waterways.

Aim. The purpose of the work is to identify the main vectors of possible development of cooperation and ways to overcome the problems arising in this cooperation by analyzing the intensity of interregional cooperation between Russia and China in the Volga — Yangtze format.

Tasks. To analyze program documents and mass-media materials in terms of coverage of the implementation of Sino-Russian projects in the Volga-Yangtze format. To carry out a quantitative analysis of existing joint projects with China in the Volga Federal District. To identify the “growth points” of further economic cooperation between Russia and China in the Volga — Yangtze format.

Methods. Empirical research methods, search and analysis of information from mass media, analysis and comparison of data, comparison and generalization were used in the work.

Results. By studying the current state of the economic component of Russian-Chinese cooperation in the Volga — Yangtze format, it was possible to identify the difficulties existing in cooperation between the two sides, which could be purposefully solved if the effectiveness of local cooperation was strengthened.

Conclusions. At the present stage, there are some obstacles to the effective development of cooperation between the regions of the Volga Federal District and the territories of the upper and middle reaches of the Yangtze River of the People’s Republic of China in the Volga — Yangtze format, such as difficulties in the macroeconomic situation in Russia, the weakness of the foundation of regional cooperation, the need for an effective coordination mechanism at the regional level, as well as clear schemes of financial and tax support. In addition, based on the geographical features of the regions and the reliance of regional economies on water resources, the development of environmental cooperation in the Volga — Yangtze format would be a progressive format of cooperation.
UNIVERSIDADE PÚBLICA, GÊNERO E PRODUÇÃO ACADÊMICA
Authors: Araujo da Silva Andréa Giordanna , Bianco de Souza Queiroz Erica
Published: March 2022

O estudo identifica os espaços reservados à discussão sobre a mulher e aos estudos de gênero na Universidade Federal de Alagoas. Trata da política de cotas por gênero e da inserção do debate das questões políticas e culturais que permeiam a questão do gênero nas produções acadêmicas no âmbito do ensino, da pesquisa e da extensão. O estudo mostra que ainda que avanços em torno da discussão de gênero no ambiente acadêmico tenham ocorrido, o debate está circunscrito ao campo das Ciências Humanas, sendo amparado numa produção acadêmica limitada e insuficiente para o contexto sociocultural em que se insere a universidade pública.
MULHERES E FUTEBOL: UM ESTUDO SOBRE ESPORTE E PRECONCEITO
Authors: Da Rosa Marcelo Victor , De Oliveira Jitsumori Carlos Igor , Monteiro Borges Andrey , De Melo Ribeiro Maria Elizia
Published: March 2022

Esta pesquisa teve por objetivo identificar preconceitos vividos por mulheres praticantes de futebol. As informações foram obtidas por meio de um questionário respondido por 47 praticantes do esporte. O preconceito acontece de forma direta e indireta, sendo proferido pela família das atletas e até mesmo pelas próprias jogadoras. Por isso, surge a necessidade de mais estudos e discussões acerca do futebol feminino, para que este seja visto como um esporte para todos/as e para que a mulher não necessite passar pelo constrangimento de ter sua sexualidade questionada simplesmente por gostar e jogar futebol.
Analisis Kemampuan Berpikir Kreatif Siswa Ditinjau dari Gaya Kognitif dalam Pembelajaran Elektronik (E-Learning) Berbasis Masalah Materi Pencemaran Lingkungan di Kelas X MIPA SMA Negeri 1 Kota Sungai Penuh
Authors: Wirsal Della , Hamidah Afreni , Asra Revis
Published: March 2022

This research uses mixed methods with a study design in sequence model aim to analize the ability of creative thinking level and the difference of creative thingking ability for student who has field independent cognitive style and field dependent cognitive style in Problem Based E-Leaning of Environmental Pollution in X MIPA class in Sungai Penuh public high school 1. Sampling of this research is 70 X MIPA students using stratifies random sampling. Quantitative data is analized with descriptive statistical technique and independent sample T-Test, while qualitative data is analized with interactive analysis technique. The analysis result is creative thinking ability of students with the field independent (FI) cognitive style is higher than the student with field dependent (FD) cognitive style in Problem Based E-Leaning of Environmental Pollution.
Keyword: Creative Thinking, Cognitive Style, Problem Based E-Learning
 
Abstrak. Penelitian ini menggunakan metode kombinasi (mixed methods), dengan rancangan penelitian berupa model urutan, yang bertujuan untuk menganalisis tingkat kemampuan berpikir kreatif dan perbedaan kemampuan berpikir kreatif pada siswa yang memiliki gaya kognitif field independent dan gaya kognitif field dependent dalam pembelajaran elektronik (e-learning) berbasis masalah materi pencemaran lingkungan di kelas X MIPA SMA Negeri 1 Kota Sungai Penuh. Sampel dalam penelitian ini terdiri dari 70 orang siswa kelas X MIPA yang diambil dengan menggunakan teknik stratified random sampling. Data kuantitatif dianalisis dengan menggunakan teknik statistik deskriptif dan Independent Sample T-Test, sedangkan data kualitatif di analisis dengan menggunakan teknik model analisis interaktif. Hasil analisis didapatkan bahwa tingkat kemampuan berpikir kreatif siswa dengan gaya kognitif field independent (FI) lebih tinggi dibandingkan siswa dengan gaya kognitif fielddependent (FD), dalam pembelajaran elektronik (e-learning) berbasis masalah materi pencemaran lingkungan.
Kata kunci: Berpikir Kreatif, Gaya Kognitif, Pembelajaran Elektronik (E-Learning) Berbasis Masalah