bluuebunny/crossref_metadata_2025 huggingface dataset:
THE VALUE OF THE IMMUNE RESPONSE IN PATIENTS WITH EBV INFECTIOUS MONONUCLEOSIS IN PREDICTING THE COURSE AND EFFICACY OF ANTIVIRAL AND IMMUNO IMMUNOCORRECTING THERAPY
Authors: Svintsova T. A. , Sobchak D. M. , Korochkina O. V. , Kravchenko G. A , Novikov V. V
Published: April 2021

The indices of immune response were studied in 68 patients with infectious mononucleosis caused by the Epstein-Barr virus (35 males, 33 females) aged 18 to 30 years. Materials and methods. The content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50, sHLAI, sCD54) has been studied with enzyme immunoassay using monoclonal antibodies Mab IC0-20 and polyclonal antibodies to the antigens of the mononuclear cells of the peripheral blood. The control group included 60 healthy volunteers matched for age and sex with the main group. The aim of this study is the assessment of the content of soluble forms of differentiation antigens in patients with infectious mononucleosis caused by Epstein-Barr virus, depending on gender, age, severity of illness, comorbidities, laboratory values, the presence of viral DNA, as well as a demonstration of their value in predicting the course and outcome of the disease and the efficacy of antiviral and immunocorrecting therapy. In patients with negative results of DNA indication of EBV a significant increase in the content of soluble forms of differentiation antigens characterizing the adhesion of leukocytes (sCD18), the activity of T-lymphocytes (sCD50), the recognition of foreign antigens (sHLAI) in the blood in comparison with patients with a positive DNA indication of EBV was determined. Conclusion. According to the results of this performed work the criterion for an adequate immune response in patients with infectious mononucleosis caused by the Epstein-Barr virus was found to be the increase of the content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50 sHLAI, sCD54). In patients with exanthema, tonsillar syndrome, leukocytosis, elevation of transaminases and the presence of antibodies to capsid antigen (a/VCAIgM) the content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50 sHLAI, sCD54), was higher than in patients without such symptoms. In the treatment with cycloferon in patients with cyclic course of EBV infectious mononucleosis the content of sHLAI and sCD54 at 2nd-4th weeks of treatment increased by 1.5-2 times compared with the corresponding values before treatment. In patients with reactivation of the disease monotonically low indices of all studied soluble forms of differentiation antigens persisted over the 4 weeks during patients following up. In patients with infectious mononucleosis caused by Epstein-Barr virus, the dynamics of sHLAI and sCD54 after 2-4 weeks of treatment serves as secondary efficacy endpoint of antiviral, immunomodulatory therapy and the formation of the cyclic course of the disease.
Dynamics of specific IgM and IgG antibodies in patients with Crimean Hemorrhagic Congo Fever
Authors: Trusova I. N. , Butenko A. M. , Larichev V. F. , Shchelkanov M. Yu , Azaryan A. R , Grishanova A. P , Ivashchenko E. I , Arshba T. E , Govorukhina M. V , Asmolova N. Yu , Sidenko I. S , Vasilenko N. F , Rusakova N. V , Shishkina L. V , Bushkieva B. Ts
Published: April 2021

338 blood sera from 254 CCHF patients residing in the south endemical areas of the Russian Federation during 2003-2010 were examined with the use of ELISA-IgM (MAC-ELISA) and ELISA-IgG methods. The dynamics of specific antibodies for a month from the beginning of the disease including patients with different clinical forms of CCHF, cases of different ages, males and females has been investigated.
The evolution of the pathogen and the clinical and epidemiological features of the recent cholera (el tor)
Authors: Savelyev V. N. , Savelyeva I. V. , Babenyshev B. V. , Kulichenko A. N.
Published: April 2021

In a comparative perspective studied cholera outbreak in the Caucasus due to typical toxigenic and genetically modified (hybrid) El Tor variant strains have been studied. Revealed features of the genetic structure of the genome, factors and ways of transmission of the causative agent of modern cholera El tor should be considered when improving the program of epidemiological supervision in terms of enhancing antiepidemic and prevention measures in cholera, the causative factor of which are of hybrid variants of Vibrio cholerae El tor.
DYNAMICS OF MENINGOCOCCAL INFECTION RATE IN THE REPUBLIC OF KARELIA
Authors: Filatova T. G. , Kovalenko A. I. , Leri M. M.
Published: April 2021

The paper presents the results of an epidemiological analysis of the incidence of meningococcal infection in the Republic of Karelia over epidemic and interepidemic periods. Year over year meningococcal infection rate in the Republic has been remaining to be higher than similar data in Russian Federation. In the years of epidemiological outbreak the number of regions being affected and the disease incidence in children under 14 increases. The largest lethality has been observed in the beginning of epidemiological outbreak. The results of the study indicate the exchange of the leader of meningococcus of serogroup В by meningococcus of serogroup C and A. In the absence of planned vaccinal prevention there remains the threat for the rise of meningococcal infection rate.
THE CLINICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THE CORRECTION OF POSTENCEPHALITIC SOMATOGENIC ASTHENIA
Authors: Sumlivaya O. N , Vorobiova N. N , Karakulova Yu. V , Veselova E. L , Shalaeva O. V , Merkurieva E. V
Published: April 2021

An open, randomized clinical study in two groups of reconvalescents of tick-borne encephalitis suffered from postencefalitic somatogenetic asthenia. The first group was consisted of 14 patients who received adamantane derivatives - ladasten at a daily dose of 100 mg for 25 days. The second comparison group included 18 convalescents who were followed up without an prescription of Ladasten. Before and after treatment, the examination with the use of a Visual Analogue Scale fatigue, scale of subjective evaluation fatigue - Multidimensional Fatigue Inventory (MFI-20), Beck Depression Inventory, D. Spielberger's test (State-Trate-Anxiety-Inventory (STAI)), adapted for Russia by Yu. L. Khanin, a questionnaire for detection signs of autonomic changes. After receiving ladasten patients showed significant dynamics of the drop in scores accordingly to visual analogue scale fatigue by 2.5 times as opposed to those in the second group, where the fall was only by 1.4 times. In the first group there were also significant fall in scores of all scales MFI-20 (p = 0.0001), Beck Depression Scale (p = 0.001), Spielberger-Khanin test (p = 0.002) and the questionnaire for evidence of autonomic changes (p = 0.001). The obtained data suggest that Ladasten at a daily dose of 100 mg is highly effective drug with antifatigue, anxiolytic and vegetostabilizing effects and can be recommended in rehabilitation period to patients after the tick-borne encephalitis with manifestations of postencefalitic somatogenetic asthenia.
IMPACT OF CHRONIC INFLAMMATORY PATHOLOGY OF ENT ORGANS ON THE QUALITY OF LIFE OF HIV-INFECTED PATIENTS
Authors: Zatoloka P. A
Published: April 2021

Indices of the quality of life were analyzed in 259 HIV-infected re—spondents at different stages of disease. There were detected average integral in—dices of physical component of health (PH=1-67,7) and psychological (mental) compon—ent of health (MH=59,1). There was detected negative impact of chronic inflam—matory pathology of ENT organs on self-assessment of the quality of life of HIV-infected people, that led to the decline in the level of both physical (PH-from 80,5 to 65,3), and psychological (MH - from 71,7 to 55,5) components of health. The most negative impact of chronic inflammatory otorhinolaryngological pathology was detected among respondents with the 2nd stage of HIV-infection (decline of PH- from 79,3 to 52,4; MH- from 64,0 to 41,6).
MUSCULOSKELETAL HYDATIDOSIS: REPORT OF TWO СASES AND REVIEW THE LITERATURE
Authors: Bronstein A. M. , Malishev N. A. , Legonkov Yu. A. , Musaev G. H. , Jarov S. N. , Sertakova O. V.
Published: April 2021

Musculoskeletal system is rarely involved by hydatid cyst, the larvalform of Echinococcus granulosus. Two cases of intramuscular hydatid cysts within thigh musculature are being reported with the intent of highlighting this atypical localization of the disease. Preoperative computerized tomography suggested an unusual location of echinococcus. Since the soft tissue tumors may be confused with hydatid cysts, preoperative evaluation of these patients is critical for proper handling during surgery to avoid life-threatening complications. Surgical excision with postoperative antihelmenthics formed the main modality. These cases emphasize that especially in endemic areas to avoid fine-needle biopsy and the risk of spillage of cyst contents hydatidosis should be included in differential diagnosis of any soft tissue mass.
THE EXPERIENCE OF THE USE OF PNEUMOCOCCAL CONJUGATE VACCINE IN YOUNG CHILDREN IN THE PERM KRAI
Authors: Zubova E. S. , Semerikov V. V , Sofronova L. V
Published: April 2021

A comparative evaluation of the reactogenicity and preventive efficacy of the use of Prevnar Pneumococcal 7-valent conjugate vaccine in healthy (N=95) and frequently ill children (N=30) has been performed. Under administration Vaccine was characterized by low reactogenicity and high prevention efficacy. Index of prophylactic efficacy among long-term and frequently ill children was 46.0 that’s 6 times higher than among healthy vaccinated children - 7.55.
A RARE CASE OF GENERALIZED LEGIONELLOSIS IN THE PRACTICE OF INFECTIOUS DISEASE PHYSICIAN
Authors: Nagibina M. V. , Tishkevich O. A. , Muravyov O. A , Kadyshev V. A. , Shakhmardanov M. Z. , Parkhomenko Yu. G. , Kulagina M. G. , Chebotarev E. Yu.
Published: April 2021

In legionellosis specific clinical manifestations and radiographic criteria are absent, so the identification of legionellosis is possible only with the widespread introduction of specific methods of laboratory diagnosis, that if necessary will allow to adjust quickly antibiotic therapy.
A prominent scientist and gifted epidemiologist (to the 110th an-54 niversary of Professor I. I. Elkin)
Authors: Knopov M. Sh. , Taranukha V. K.
Published: April 2021

In the article the life way and the career of an outstanding Russian epidemiologist, talented Organizer of Health care, well-known public figure, a remarkable pedagogue, honored worker of a science of Uzbek SSR Professor Ivan Ivanovich Elkin has been presented
RISK FACTORS FOR THE DEVELOPMENT OF NON-HODGKIN’S LYMPHOMA IN PATIENTS WITH HIV AND HEPATITIS С COINFECTION
Authors: Melnikova E. L , Volchkova E. V , Ivannikov E. V , Olshansky A. Ya , Vdovina V. N , Parkhomenko Yu. G
Published: April 2021

The objective of the study was to investigate risk factors for the development of non-Hodgkin's lymphoma (NHL) in HIV-infected patients with hepatitis С virus (HCV) coinfection. A total of 37 HIV-positive subjects with NHL treated in the Moscow Center for Prevention and Control of AIDS between 2009 and 2013 were included in the study. HIV patients were divided into 2 groups: 23 cases with HCV coinfection and 14 patients without HCV coinfection. At the time of making the diagnosis of NHL 90% of patients had CD4 cell count < 350 cell/mm 3. The mean CD4 cell count in the first group (120±123 cell/mm 3) was significantly lower (p=0,035), than in patients without HCV coinfection (267±253 cell/mm3). At the time of making the diagnosis of NHL 70% of patients had HIV viral load ≥5,00 log10. The mean viral load was 5,47±1,09 log10 copies/ml in the first group and 4,06±2,03 log10 copies/ml in the second group (p=0,033). At the time of making the diagnosis of NHL 78% of patients did not receive combination antiretroviral therapy (cART). In most patients who received cART virologic suppression unsufficient and CD4 cell count remained to be low. Risk factors associated with an increased risk of NHL in HIV-infected patients with HCV coinfection are low CD4 cell count, high HIV viral load and lack of effective cART. Timely initiation of cART followed by complete virologic suppression and CD4 recovery are key factors to prevent NHL in HIV-infected patients.
Lipopolysaccharides/endotoxins of gram-negative bacteria: their role in the development of intoxication
Authors: Gyulazyan N. M. , Belaia O. F. , Malovv V. A , G Paks. Grigor'evich , Volchkova E. V.
Published: April 2021

Numerous clinical and experimental studies allow us to consider bacterial endotoxins as the main factors inducing the development of intoxication syndrome in infectious and non-infectious diseases. LPS is themajor structural component of Gram-negative bacteria; its effect on the body is related to all the objective clinical manifestations of intoxication. The activation of immune cells by LPS results in the release of inflammatory mediators: cytokines, chemokines, enzymes, eicosanoids, adhesion agents and free radicals that are responsible for the progression of inflammatory reactions and may induce pathophysiological processes including septic shock. Currently, various techniques are developed and used for endotoxin /LPS determinationin biological environmentsthat are based both on detection of its serological markers and registration of its biological effects.
Seasonal fluctuations of H.Pylori markers in patients with acute viral hepatitis
Authors: Belaia O. F. , Zuevskaya S. N. , Paevskaya O. A. , Yudina YU. V. , Volchkova E. V. , Pak S. G.
Published: April 2021

Under investigation of the dynamics of pathogenicity factors H. pylori (LPS/O-antigen markers VacA and high molecular weight proteins (HMWP) (including CagA) in the body ofpatients with acute viral hepatitis (AVH) of different etiology there were established seasonal patterns in feces and serum circulating immune complexes (CIC): LPS/O-antigen markers and H. pylori VacA included in CIC. The detection rate and levels of markers of H. pylori in patients who had AVH in January-April exceeded similar indices in patients whi had AVH in May-August. We believe that these data should be considered in the assessment of the results of the diagnosis ofH. pylori and results of eradication therapy.
Monitoring for incidence of Yersiniosis and environmental contamination by these pathogens in the Tyumen region. Report 1. Regularities of the epidemic process of Yersinioses iersiniozov in the Tyumen region
Authors: Mefodev V. V. , Perminova K. G. , Dubinina O. A.
Published: April 2021

There was established the stabilization of the incidence of these infections in the long-term dynamics, that is caused by constant actingfactors. There are determined risk territories (Tyumen, one rural forest-steppe district and three rural districts of southern boreal forest), risk groups: children aged 3-6 and 7-14 years for Yersiniosis enterocolitica and Yersiniosis pseudotuberculosis and children 3-6 of years for Yersiniosis enterocolitica, risk time: January June for pseudotuberculosis and for January, March, May, June, August, October for Yersiniosis enterocolitica. The intensity of contamination of vegetables and fruits by Yersinia-bacterias on months correlates with incidence of these infections (average, moderate relationship; r = 0,57 ± 0,19). To control the epidemic process of Yersinioses there is reasonable the improvement of the system of epidemiological surveillance and elaboration of the program of interrelationship and interaction between involved bodies and institutions of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance, State Agricultural Committee and the educational sphere.
West Nile Fever in the Tula region, Russian Federation
Authors: Butenko A. M. , Kozlova A. A. , Larichev V. F. , Dzagurova T. K. , Pantykhova R. A , Vazhnenkova N. S. , Karlova V. M. , Vasilkova O. I.
Published: April 2021

As a result of serological testing (MAC-ELISA, ELISA-IgG and neutralization test) 143 sera from 132 patients with acute febrile disease of unknown etiology hospitalized in summer 2012 in the hospitals of Tula, the first time in Tula and the Tula region were diagnosed 4 cases of West Nile fever. The age ofpatients was 42, 60, 62 and 64. They all got sick in August 2012. The temperature reached 39-40°C. Duration of disease from 13 to 20 days, the duration of hospitalization from 8 to17 days. Neurological symptoms were observed in two patients in the form of meningeal syndrome and encephalopathy with asthenic symptoms (in one case) and faint meningeal syndrome (in another).
Comparative analysis of the genome regions associated with virulence in original classic and El Tor Biovars of Vibrio cholerae strains
Authors: Kul’shan T. A. , Cheldyshova N. B. , Guseva N. P. , Smirnova N. I.
Published: April 2021

The comparative analysis of the genome regions associated with virulence in various V. cholerae strains: classical biovar, as well as typical and genetically altered strains of El Tor biovar was performed with the use of PCR assays and fragment sequencing. V. cholerae classical biovar genome was demonstrated to be more stable in comparison with the same in V. cholerae El Tor biovar. Within the genome of El Tor vibrios there were identified extensive variable regions carrying pathogenicity genes. It was also found that unlike classical cholera vibrios, in the V. cholerae El Tor genome there is absent CRISPR-system limiting horizontal transfer of the genes. The obtained data concerning these structural peculiarities of V. cholerae El Tor genome may be used in the delivery of the new generations of gene-diagnostic preparations and for improvement of molecular-epidemiological monitoring in case of cholera.
RISK OF PROFESSIONAL INFECTION WITH ZOONOSES
Authors: Nafeev A. A
Published: April 2021

In this paper there is presented a material about the risk of infection of livestock workers with pathogens of Coxiellosis (Q fever), leptospirosis and pet shop workers - with psittacosis. The use of modern methods of laboratory diagnosis with taking into account the professional factors and the nature of infectious diseases (zoonoses) has played a leading role in identifying such cases.
Liver cirrhosis and hepatocellular carcinoma in patients with chronic viral hepatitis c: some epidemiologic and molecular-genetic aspects
Authors: Nikolaeva L. I , Leybman E. A , Sapronov G. V , Yudin A. N
Published: April 2021

The aim of this review is to analyze the modern epidemiological and molecular-genetic data concerning development of liver cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis C. There were considered peculiarities of the occurrence of this pathology in adult patients and children with hepatitis C.
Hepatitis C in infection with recombinant strain RF2k/1b of the virus: clinical course and therapy
Authors: Nikolaeva L. I , Sapronov G. V , Kolotvin A. V , Samokhvalov E. I , Leybman E. A , Samokhodskaya L. M
Published: April 2021

Intergenotype recombinant RF2k/1b of hepatitis C virus was firstly detected in 2002 in the Russian Federation. In our study patients, infected with this recombinant, had high indices of liver fibrosis and did not achieve a sustained viral response to standard double therapy with exception of one participant. There are discussed and proposed options for treatment and diagnosis of these patients.
Epidemiological evaluation of meningococcal infection in the Altai Krai
Authors: Shirokostup S. V , Safianova T. V , Krapivina E. A , Verevkina E. A , Nikishina K. A , Mezhevova V. E
Published: April 2021

In the paper there are presented the main characteristics of the epidemic process of meningococcal infection in the Altai Krai in 2003-2012. The results of the study showed that the incidence was characterized by trend of the declining morbidity rate by 5 times from 3,34 ± 0,17 to 0,66 ± 0,17per 100 thousand of population, respectively (p
Clinical - pathogenetical features of Cryptococcus meningoencephalitis in patients with HIV infection
Authors: Volkova O. E , Vengerov Yu. Ya , Safonova A. P , Svistunova T. S , Tishkevich O. A
Published: April 2021

The purpose of research - the study of clinical and pathogenetical features of cryptococcal meningoencephalitis (CME) in patients with HIV infection for the improvement of the efficiency of diagnosis and treatment. Materials and Methods. There are presented the results of the study of 67 cases of cryptococcal meningoencephalitis in patients with HIV infection. There was performed an assessment of the clinical picture and the cerebrospinal fluid (CSF), which was consisted of direct microscopy, cultural method and PCR. Also pathomorphological data of deceased patients have been analyzed. Results of the study. The clinical picture of CME was mildly pronounced and not constant. Dominant complaint is constant headache diffuse in character. Meningeal symptoms are uncertain or absent. CSF changes are not specific, most informative methods are PCR and mycological study of CSF. The fatality was causedfirst ofall by the development of edema-brain swelling and the dislocation of stem structures. Conclusion. The clinical picture of cryptococcal meningoencephalitis is caused first of all by destructive processes in brain tissue and progression of the development of edema-brain swelling. The clinical picture is poorly pronounced and is not constant, therefore to all patients with HIV infection in the presence of long-term headache the CSF examination is indicated even in the absence of meningeal symptoms.
Study of prevalence of chlamydial infection and other STIs in youth in the Kursk Region on results of the regional dedicated programme
Authors: Anisimova N. S , Leonova I. Yu , Bredikhina L. A , Knyaz'kova L. V , Starodubova N. I. , Gushchin A. E
Published: April 2021

Young people are at high risk for STIs. Along with this, for youth there is typical a low level of knowledge about STIs and prevention of infection. Therefore, an important element of prevention is the informing young people about STIs and their implications for reproductive health. The purpose of the study - to evaluate the prevalence of STIs among young people, who voluntarily turned in a perinatal center for examination after the outreach. A high prevalence of STIs among youth Kursk region was established as in the group with complaints and in cases without them. The first place in the structure of STI is occupied by chlamydial infection (77.5%). The creation and work of centers for the prevention of STIs among young people is a key mechanism in the prevention of disorders of the reproductive function in adolescents.
The features of tick-borne encephalitis in the Yaroslavl region at the present stage. The problem of evolution of the infection
Authors: Gerasimov S. G , Druzhinina T. A , Karan L. S , Kolyasnikova N. M , Baranova N. S , Levina L. S , Malenko G. V , Pogodina V. V , Bochkova N. G
Published: April 2021

In the Yaroslavl region (Central Federal District of Russia), endemic of tick-borne encephalitis (TBE), the features of epidemiology of this infection were studied during 1992-2012. Cyclical fluctuations in the incidence of TBE, the lack of the trend to decrease of the incidence were observed, the average annual incidence was 1,6 ± 0,32 per 100 thousand ofpopulation. The prevalence offebrile forms of disease was 62,2%, meningeal forms - 16,3%, the total percentage offocal forms was 13,9%. Manifestations of evolution of TBE were: the increase of the epidemiological significance of anthropogenically transformed natural foci, anthropurgical foci of TBE, until 81% of TBE cases were unvaccinated citizens, the high lethality of 4% and the high frequency of cases of alimentary infection of TBE of 7,8% with lethality of 10,8%. The aethiological agent of 10 lethal cases was Siberian subtype of TBE virus.
Diversity of LPS/O-antigens of causative agents of intestinal infections in HIV-infected patients at the stage of secondary diseases
Authors: Korogodskaia E. G , Umbetova K. T , Belaia O. F , Mazus A. I , Yudina Yu. V , Belaia Yu. A , Smetanina S. V , Allenov M. N , Pak S. G
Published: April 2021

The goal was to establish the frequency of detection of LPS O antigens of common causative agents of intestinal infections in HIV-infected patients at the stage of secondary diseases. Materials and methods. The study included 48 HIV-infected patients at the stage 4A, 4Б, 4B (25 men and 23 women), without diarrhea, a mean age ofpatients was 36,78 ± 7,8 years. Stool samples (2-4 samples from patient in interval of 5-7 days) were studied for the presence of LPS/O-antigens of S.sonnei, S.flexneri 1-5, 6, Salmonella sgr. B, C1, C2, D, E, Y.pseudotuberculosis I, III, Y.enterocolitica 03, 09, Campylobacter (C.jejuni, C.coli, C.lari) in coagglutination. Results. It was found that HIV-infected patients at the stage of secondary diseases have relatively high presence of LPS/Oantigens of various pathogens - Shigella, Salmonella, Yersinia, in feces (72, 55%). But Campylobacter antigens were relatively rare. In stages 4A, 4Б and 4В overall detection rate of LPS/O-antigens in stool samples did not differ significantly and was 64,3%, 91,3%, 68,6%, respectively (r ≥ 0,05). Conclusion. The high content of LPS/O-antigens may increase the toxic load in patients with HIV infection, including the immune system.
Characterization of the microflora of ventilator-associated respiratory tract infections in patients with severe trauma
Authors: Orlova O. A , Akimkin V. G
Published: April 2021

Rationale The relevance of ventilator-associated respiratory tract infections in severe injury patients (SIP) is associated with both features of causative pathogens and the initial severity of the state of patients. Among causative pathogens nosocomial flora is dominant. Purpose - to perform an analysis of the microbiological monitoring of ventilator-associated respiratory tract infections in SIP. The analysis was based on the results of a prospective epidemiological, clinical, and instrumental study of 100 SIP with ventilator-associated respiratory tract infections, stayed in the surgical intensive care unit. The proportion of ventilator-associated respiratory infections in the structure of nosocomial infections in these patients is between 90 - 95%, at that there was revealed the prevalence of nosocomial pneumonia (61%). Ventilator-associated respiratory tract infection most commonly occurs during the first 10 days of mechanical ventilation. The prevailing flora was represented by Gram negative Acinetobacter baumamnnii (40.3 ± 2.1%) and Pseudomonas aeruginosa (38.4% ± 3.2%). Isolated microorganisms possessed multiple antibiotic resistance, with the greatest extent to aminoglycosides - 69.5%, fluoroquinolones - 40.3%, penicillin - 37.6%; cephalosporins (third generation) - 33.8%. There is noted marked preponderance of microbial associations compared with monocultures 57.1 ± 5.3%.
A set of activities carried out by the medical organization to prevent the introduction and spread of infectious diseases, causing an emergency situation in the field of sanitary and epidemiological welfare of the population
Authors: Suranova T. G , Chikova S. S , Shirokov A. Yu , Nikiforov V. V
Published: April 2021

There was considered the set of activities being implemented by the medical organization to prevent the carrying and spread of infectious diseases, which give rise an emergency situation in the field of sanitary and epidemiological welfare of the population. It is indicated to the need to advance the readiness of medical organization by means of holding exercises and thematic improvement for special programs.
New generation of policlonal enteroviral diagnostic sera
Authors: Kozlov V. G
Published: April 2021

The human non-polio enteroviruses (NPEV) are ubiquitous viruses found worldwide. NPEV are etiological agents of various diseases. Traditional method of identification NPEV is the detection of serotype with the use of neutralizing serotype-specific sera. Limiting amount ofproduced horse enteroviruses reference serum is not available for practical diagnostic laboratories. In the paper there are presented the results of the improvement of methods for delivery of diagnostic enteroviral rabbit sera for the reaction of neutralization in amounts sufficient to national health care.
Varicella in the Primorsky Krai: Clinical and epidemiological determinants of the prevalence
Authors: Popov A. F , Kolpakov S. L , Voronok V. M , Simakova A. I
Published: April 2021

There was analyzed the incidence of chickenpox from 2002 to 2012 in all administrative-territorial entities of the Primorsky Krai. The prevalence in adults in the Primorsky Krai in 2009-2013 corresponded to 36.7 0/ 0000. Among hospitalized patients there were prevailed cases with moderate grade, shortfebrile period (2,6 ± 1,4 days), the prevalence of subfebrile temperature, the manifestation of a typical exanthema, without complications. For varicella in the Primorsky Krai in the long-term dynamics there is typical inapparent cyclicism, the stable reservoir of infection in the off-season period, the high prevalence in infants under one year and adults. The main regulatory role in the spread of varicella is played by the implementation of the mechanism of transmission.
il 28B polymorphisms and the prognosis for the efficacy of antiviral therapy in viral hepatitis C patients in Uzbekistan
Authors: Sekler D. E , Khudayberganova D. M , Latypov R. R , Usmanova G. Z , Rakhmanov M. I , Musabaev E. I
Published: April 2021

Introduction: By means of the Association for the Study of complete genome there was identified the prognostic value of polymorphisms associated with single-nucleotide substitutions (SNP) in the human genome and located in the region of the gene IL28B/IFN-L3. Hereafter also there were identified SNP in the gene IFN-L4 and there was found a correlation between the population and the spontaneous elimination of HCV infection. Methods: In the studies there was used the materialfrom 135 HCV-infected persons residing on the territory of Uzbekistan. DNA was isolated from peripheral blood mononuclear cells (PBMC), then SNP genotyping of the IFN-L3 gene region (rs8099917, rs12979860) was performed by means of three methods: Invader Plus Assay, TaqMan Assay and direct sequencing. The plot of the IFN-L4 gene (ss469415590) was sequenced. Results: Out of the 135 studied patients, who received antiviral treatment according to the standard scheme Peg-IFN-a in combination with RBVfor 24 and 48 weeks, 87,4% were belonged to the Central Asian (CA) ethnic group and 12.6% - Eastern European (EE). Among the examined cases, there no virological response to antiviral therapy was observed in 21.2% of patients from CA group and 35.3% of EE patients (p
Social aspects of mortality from chronic viral hepatitides in rural and urban populations of the Altai territory
Authors: Saldan I. P , Pashkov A. P
Published: April 2021

In the rural population, died people were revealed more often to be of working age, the diagnosis to them statistically significantly more often was established after the death by the doctor, just has attested the death, and by the doctor-pathologist. By comparing the results obtained with the incidence rate, we came to the conclusion that in the rural population there is decreased the quality of diagnosis of chronic viral hepatitides, that leads to the upsurge of the hidden sources of infection.
Clinical and epidemiological features of the disease caused by the Ebola virus, at the present stage: pathogenetic basis of therapy
Authors: Kiselev O. I , Tsybalova L. M , Deeva E. G , Tsvetkov V. V , Golobokov G. S , Tokin I. I , Sologub T. V
Published: April 2021

Ebola virus disease (EVD), formerly known as Ebola haemorrhagic fever is severe acute infectious diseases accompanied by the development of severe systemic inflammatory response followed by the addition of disseminated intravascular coagulation and multiple organ failure. Since 1976 in Africa regularly observed disease outbreaks among humans caused by different types of Ebola virus. Modern epidemic in West Africa began in Guinea in February 2014 and is still going on, coming out of the country and distributed in Liberia, Sierra Leone and Nigeria. According to the World Health Organization (WHO) on December 14, 2014 recorded 18,603 cases of them confirmed EVD 11807, fatal 6915. From July 2014 to currently registered sporadic cases EVD among health care workers caring for patients, as well as among tourists returning from countries affected by the epidemic is already outside of West Africa. Due to the limited use of specific antiviral therapy with special attention to the management ofpatients with EVD should be paid to the intensive and timely pathogenetic therapy. Today, the only way to reduce morbidity and mortality among people from EVD is awareness on the risk factors of infection and the use ofpersonal protective measures.
Diversity of detected pathogens from patients with erysipelas
Authors: Troitskiy V. I , Erovichenkov A. A , Potekaeva S. A , Svistunova T. S , Belaya O. F , Volchkova E. V
Published: April 2021

Objective To study the etiological structure of the disease in patients with various forms of erysipelas of the lower extremities by using bacteriological method. Materials and methods A total of 50 in-patients with erysipelas of the lower limbs, mainly with bullous hemorrhagic form, were examined. Using bacteriological method we examined blood, smears from the skin in the area of the hearth and bulls punctate. The study demonstrated the preferential identification of staphylococcus, mainly - in smears from the skin, while the informativeness of blood culture and bulls punctate was low. Conclusion The positive results of bacteriological research can serve as an objective criterion of therapy correction based on identified microbes.
Assessment of the intensity of the epidemic process of ventilator-associated respiratory tract infections in patients of surgical intensive care unit
Authors: Orlova O. A , Akimkin V. G
Published: April 2021

The urgency of the problem of ventilator-associated respiratory tract infections is stipulated by the ever-increasing number of diseases caused by nosocomial polyantibiotic-resistant strains and high mortality rate. Purpose - to give an assessment of the intensity of the epidemic process of ventilator-associated respiratory tract infections in patients of the surgical intensive care unit. In the base of the analysis there were put the results of a comprehensive epidemiological, clinical, and instrumental study of 137 patients (100 patients with severe injuries and 37 patients with diseases of the abdomen and thorax) with ventilator - associated respiratory tract infections received medical treatment in the surgical intensive care unit. The proportion of respiratory tract infections in the structure of nosocomial infections in these patients varies from 34.6 to 58.9 %, in that there was revealed the prevalence of nosocomial pneumonias (63.5 %). When using a ventilator with viral-bacterial filters signs of nosocomial respiratory tract infections were manifested on the 10th day and later in 50.8 % of patients. In cases with the duration of artificial ventilation more than 10 days the risk of the development of these infections in patients with diseases of the abdominal cavity and thorax was 2.1 times higher than in patients with injuries. There was shown the necessity of the development of a set of measures for the prevention of nosocomial infections of the respiratory tract.
Pages of history of domestic military epidemiology (to 70 Years of Victory in the Great Patriotic War)
Authors: Knopov M. Sh , Taranukha V. K
Published: April 2021

Great patriotic war was the most essential stage in development of domestic military epidemiology - the stage, characterized by creation of the slender and effective, scientifically reasonable system of the anti-epidemic assurance of troops in accordance with a concretely appearing battle epidemiological situation. In the years of war military epidemiology along with the organizational progress was enriched by new theoretical conceptualization, new different methods of work, that, undoubtedly, provided further development of medical science and the elevation of the level and efficiency of epidemiology work in troops.
Clinical and laboratory characteristics of influenza in pregnant women in the epidemiological season of 2013-2014
Authors: Deeva Ella G. , Sologub T. V , Tikhonova E. P , Krasnova E. I , Konovalova N. I , Zarubaev V. V , Eropkin M. Yu , Tsvetkov V. V , Golobokov G. S
Published: April 2021

By force of hormonal and physiological changes occurring in the body throughout pregnancy, in the case of the flu, pregnant women are at greater risk of developing complications. In this regard, the study of clinical and pathogenetic features of influenza in pregnant women deserves special attention. So, on the basis of epidemiological data over the past few decades, WHO experts have included pregnant women in groups at risk of severe (complicated) course of the flu. The flu for a pregnant female is a dangerous infection, representing a real threat to the health of the expectant mother and her child. The clinical picture of influenza in pregnant women can vary significantly, and severe complications combine with the development of a pathology of pregnancy, which ultimately exacerbates the condition as well an expectant mother as the fetus. For the study both of the character of the clinical course of influenza in pregnant women and the mechanism of the immunosuppressive state FGBU "Influenza Research Institute" performed a simple multi-center comparative study on the base of the infectious-disease units of the GBOU "NGMU" and the Medical University "KrasGMU named after. prof. V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation. The obtained results allowed to reveal some clinical and immunological features of the course of influenza in pregnant women: at the peak of the disease there was noted a significant inhibition of induced production of IFN-γ.
Analysis of the fragmented and full genome sequencing of atypical Vibrio Cholerae strains of the classical biovar, which brought about to the outbreak of the Asian cholera in Russia
Authors: Cheldyshova N. B , Kritskiy A. A , Krasnov Ya. M , Smirnova N. I
Published: April 2021

The aim of the research was the study of genetic changes in the genome of classical strains of Vibrio Cholerae which brought about to the atypical outbreak of Asian cholera in Russia in 1942 - 1943. Genome-wide and fragmented sequencing of mentioned strains revealed the presence of mutations in their structural (tcpC, tcpF, tcpS, purE) and regulatory (vieA, vieS, toxR, hapR, rpoS, crp) genes. The overproduction of CT and TCP, as well as the lack of production NAR were found to be caused by mutations in regulatory genes (hapR and rpoS). Adenine auxotrophy in V. cholerae strain M-29 is associated with a mutation in a gene purE. Thus, atypicality of the epidemic and clinical processes in the outbreak of cholera in Russia in 1942 - 1943 was associated with a combination of phenotypic features (auxotrophy, overproduction CT, TCP, lack of product HAP) of strains which brought it, caused by mutations in the structural (purE) and regulatory (hapR and rpoS) genes with social factors (war, starvation, weakened body of prisoners).
Manifestations and risk factors of epidemical process of devicerelated infections of urinary tract's in patients of intensive care unit and epidemiological safe order of urinary catheterization
Authors: Sergevnin V. I , Klyuchareva N. M
Published: April 2021

It was determined, that epidemical process device-related infections of the urinary tract in patients of intensive care unit was established to be characterized by high intensity, prevalence of Pseudomonas aeruginosa in the etiological structure of the disease, predominant occurrence of infection in patients over 50 years, particularly females, on the background of severe traumas and long period of urinary catheterization. According to results of visual estimation in 32 cases of urinary catheterization there was detected the frequency of its disorders in conditions of medical institutions and there was developed epidemiologically safe order of the implementation of this procedure.
Comparative identificational characteristic of artificial leather with embossed surface damages caused by airgun pistol pellets with different head end forms
Authors: Alyabyev Fedor V. , Belousova Olga A. , Chesalov Nazariy P. , Lubina Tatiana A. , Sapega Anna S.
Published: April 2021

Background: Authors of this article have made a comparative identificational description of artificial leather damage caused by air gun pistol pellets with different head end forms. Aim: This study aimed to provide a comparative identification characteristic of injuries caused by shots from an air pistol MP-53 M on artificial leather with a raised surface and a textile net glued to the wrong side at different angles and from different distances by bullets with different head end shapes (hemispherical, flat round, and conical). Used: Air pistol MP-53M, bullets with different head end shape, a fragment of black artificial leather with an embossed surface, and a textile mesh glued to the wrong side. Shots were fired at close range, 50 and 100 cm at angles of 30, 45, 60, and 90. The prevailing forms of damage (defects) of artificial skin, characteristic of bullets with a hemispherical, conical, and flat rounded head end, dependence of the form of damage (defect) on the distance of the shot, and the angle of entry of the bullet into the material. Conclusion: A comparative study showed that the form of damage to the material depends on the head end shape of bullets. Moreover, intragroup differences were found in the damage due to the distance of the shot and angle of entry of the bullet into the material in groups of bullets with the same head end shape.
RÉSIF-SI: A Distributed Information System for French Seismological Data
Authors: Péquegnat Catherine , Schaeffer Jonathan , Satriano Claudio , Pedersen Helle , Touvier Jérôme , Saurel Jean-Marie , Calvet Marie , Stehly Laurent , Arnoul Patrick , Bollard Philippe , Dewée Olivier , Engels Fabien , Grunberg Marc , Pardo Constanza , Wolyniec David , Arneodo Grégory , Bouazzouz Rima , Geber Olivier , Aubert Coralie , Langlais Mickaël , Roussel Sandrine , Brenguier Florent , Crawford Wayne C. , Lemarchand Arnaud , Maufroy Emeline , Olivier Serge , Rivet Diane , Vallée Martin , Vergne Jérôme , Chèze Jérôme , Debayle Éric , Delouis Bertrand , Guéguen Philippe , Lambotte Sophie , Mocquet Antoine , Paul Anne , Peix Fabrice , Schindelé François , Shapiro Nikolai , Stutzmann Éléonore , Volcke Pierre , Walpersdorf Andrea
Published: April 2021

The Résif project, which started in 2008, aims at gathering under a common research infrastructure the French seismological, Global Navigation Satellite Systems and gravimeter permanent networks, as well as the mobile instrument pools. A central part of Résif is its seismological information system, Système d'Information de Résif (Résif-SI) (started in 2012), which is in charge of collecting, validating, archiving, and distributing seismological data and metadata from seven national centers. Résif-SI follows a distributed architecture, in which the six data collection and validation centers (A-nodes) send validated data and metadata to a national data center (Résif Data Center [Résif-DC]), which is the central point for data archiving and distribution. Résif-SI is based on international standard formats and protocols, and is fully integrated into European and international data exchange systems (European Integrated Data Archive, European Plate Observing System [EPOS], Incorporated Research Institutions for Seismology, International Federation of Digital Seismograph Networks). In this article, we present the organization of Résif-SI, the technical details of its implementation, and the catalog of services provided to the end users. The article is aimed both at seismologists, who want to discover and use Résif data, and at data center operators, who might be interested in the technical choices made in the implementation of Résif-SI. We believe that Résif-SI can be a model for other countries facing the problem of integrating different organizations into a centralized seismological information system.
Thrombocytopenia and thrombocytosis as a predictor of neonatal sepsis: a hospital-based cross-sectional study
Authors: Babji N. Shivaramakrishna , Jayasheel Ajay , Veerapu Nagapraveen
Published: April 2021

Background: Hematological changes in sepsis can aid in the early diagnosis of sepsis even before the culture reports are obtained. Of the various hematological parameters, the platelet count can be an early marker for sepsis. This study was carried out to evaluate the role of thrombocytopenia and thrombocytosis as a marker of sepsis in neonates.Methods: A cross-sectional study was carried out at neonatal intensive care unit (NICU) at a tertiary care center from1st January 2014 to 30th September 2014. During this period,623 neonates had features suggestive of sepsis, of which 190 turned to be having culture-positive sepsis. One hundred and ninety neonates aged between 0 to 28 days of life admitted in NICU with culture-positive sepsis were included in the study. The newborns were categorized based on platelet count and type of organism cultured. Chi square test was used to test statistical significance. P<0.05 was considered statistically significant.Results: Among 190 participants, 50% had gram-positive organisms in culture, 37.9% had gram-negative sepsis, and 12.1% had fungal sepsis. The prevalence of thrombocytopenia among the participants was 39.47%. There was a statistically significant difference across the type of organism in sepsis (p<0.05). The difference in outcome across the platelet count status was insignificant, with a p=0.391. Conclusions: The most common organism causing neonatal sepsis was gram-positive organisms, followed by gram-negative organisms and fungus. Thrombocytopenia was present in all forms of neonatal sepsis irrespective of the causation. Hence, thrombocytopenia can be considered as an early marker of neonatal sepsis.
Dealing with tuberculosis: factors of the tuberculosis medication adherence among marginalized communities: a scoping literature review
Authors: Nasrin Shamema , Chowdhury N. M. Rabiul Awal
Published: April 2021

Marginalized communities have a prolonged experience of Tuberculosis (TB) with high prevalence. The rationalization behind the high rate is often indicted due to low medication adherence and its cultural and economic aspects. This scoping literature review assessed the influencing factors of patient TB medicine adherence, examined the conceptualization of factors, and determined the gaps related to TB medicine adherence presented in the empirical studies. Three electronic databases had been searched for selecting relevant studies published from 2000 to 2020 March. Studies associated with original research, review, classical and comparative articles on infectious TB in marginalized communities were considered under selection criteria. Finally, thirty articles met the inclusion criteria throughout the Prisma flow diagram; charting table and study characteristics have formed; results were discussed based on the study findings. Indigenous people, ethnic minorities, migrant communities, homeless, prisoners, alcohol and drug users, foreign-born, the working class, sex workers, and immune-compromised individuals suffer more from TB than the mainstream population. The concept of TB medication adherence has been illustrated as a socio-cultural and economic problem, personal beliefs, and the TB recipient's practices regarding illness and health-seeking behaviors. Most of the studies focused on the subjectified experiences of people because the 'recipient's/ patient's perspectives' on medicine adherence were being viewed by outsider’s approach. Few studies recommend prospective learning from the recipient's point of view; examine and conceptualize the political-economic factors for intensifying medication adherence. These records may use further to perform and estimate programs for better health consequences.