bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Surgical Tumor Resection Deregulates Hallmarks of Cancer in Resected Tissue and the Surrounding Microenvironment
Authors: Chaubal Rohan , Gardi Nilesh , Joshi Shalaka , Pantvaidya Gouri , Kadam Rasika , Vanmali Vaibhav , Hawaldar Rohini , Talker Elizabeth , Chitra Jaya , Gera Poonam , Bhatia Dimple , Kalkar Prajakta , Gurav Mamta , Shetty Omshree , Desai Sangeeta , Krishnan Neeraja M. , Nair Nita , Parmar Vani , Dutt Amit , Panda Binay , Gupta Sudeep , Badwe Rajendra
Published: June 2024

Abstract
Surgery exposes tumor tissue to severe hypoxia and mechanical stress leading to rapid gene expression changes in the tumor and its microenvironment, which remain poorly characterized. We biopsied tumor and adjacent normal tissues from patients with breast (n = 81) and head/neck squamous cancers (HNSC; n = 10) at the beginning (A), during (B), and end of surgery (C). Tumor/normal RNA from 46/81 patients with breast cancer was subjected to mRNA-Seq using Illumina short-read technology, and from nine patients with HNSC to whole-transcriptome microarray with Illumina BeadArray. Pathways and genes involved in 7 of 10 known cancer hallmarks, namely, tumor-promoting inflammation (TNF-A, NFK-B, IL18 pathways), activation of invasion and migration (various extracellular matrix–related pathways, cell migration), sustained proliferative signaling (K-Ras Signaling), evasion of growth suppressors (P53 signaling, regulation of cell death), deregulating cellular energetics (response to lipid, secreted factors, and adipogenesis), inducing angiogenesis (hypoxia signaling, myogenesis), and avoiding immune destruction (CTLA4 and PDL1) were significantly deregulated during surgical resection (time points A vs. B vs. C). These findings were validated using NanoString assays in independent pre/intra/post-operative breast cancer samples from 48 patients. In a comparison of gene expression data from biopsy (analogous to time point A) with surgical resection samples (analogous to time point C) from The Cancer Genome Atlas study, the top deregulated genes were the same as identified in our analysis, in five of the seven studied cancer types. This study suggests that surgical extirpation deregulates the hallmarks of cancer in primary tumors and adjacent normal tissue across different cancers.
Implications:
Surgery deregulates hallmarks of cancer in human tissue.
Table S7 from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Table S7: C-miR risk sum score of hsa-let-7e-5p, hsa-miR-10b-5p and hsa-miR-3613-5p in MLH1 sample. Unadjusted and sex- adjusted models. b = regression coefficient; HR = hazard ratio; 95% CI = 95% confidence interval; P-value = P-value significant at <0.05 level; Full model C-index = Harrel’s concordance (C) index. N = 74 of whom 14 developed cancers during the surveillance
Table S4 from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Table S4: C-miR full model. HR = hazard ratio, 95% CI = 95% confidence interval, b= regression coefficient, SE = standard error, df = degrees of freedom. P significant at 0.05 level.
Table S2 from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Table S2: Cancer characteristics.
Table S12 from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Table S12: The experimentally verified c-miR risk sum target genes from miRTarBase.
Table S10 from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Table S10: C-miR risk sum score in CRC samples. Unadjusted and sex and MMR-variant adjusted models. b = regression coefficient; HR = hazard ratio; 95% CI = 95% confidence interval; P-value = P-value significant at <0.05 level; Full model C- index = Harrel’s concordance (C) index. N = 74 of whom 14 developed cancers during the surveillance.
Methods S1 from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Methods S1: This code supplementary file was used to perform the differential expression analysis as well as to develop the c-miR cancer risk prediction model described in the manuscript.
Data from Low-Carbohydrate Diet Score and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study
Authors: Pham Yen Thi-Hai , Jin Aizhen , Wang Renwei , Behari Jaideep , Koh Woon-Puay , Yuan Jian-Min , Luu Hung N.
Published: June 2024

Abstract
Limited data are reported on the association between low-carbohydrate diet (LCD) score, a comprehensive measure of dietary pattern according to sources of carbohydrate, fat, and protein, and risk of hepatocellular carcinoma (HCC). We evaluated this score with HCC risk in the Singapore Chinese Health Study, a prospective cohort of 63,275 middle-aged and elderly Chinese living in Singapore and recruited during 1993–1998 period. LCD scores were derived from the semi-quantitative food frequency questionnaire at baseline. A nested case–control study involved 197 HCC cases and 465 controls was also constructed among 28,346 participants who provided blood samples. Cox proportional hazard regression method was used to calculate HRs and 95% confidence intervals (CI) for HCC with different levels of LCD scores. Conditional logistic regression was performed for the case–control study analysis. After 17.6 years of follow-up with 819,573 person-years, 561 participants developed primary HCC. Although there was a null association between total LCD score and HCC risk (HRper-SD increment = 1.07; 95% CI, 0.98–1.16; Ptrend = 0.06), there was a positive association between animal-based LCD and the risk of HCC (HRper-SD increment = 1.11; 95% CI, 1.02–1.21; Ptrend = 0.01). Furthermore, this association was present in both HBsAg-negative and HBsAg-positive individuals in the case–control study. In stratified analysis for the entire cohort, this positive association was only present in those who consumed alcoholic beverages monthly or less frequent but not in weekly or daily drinker (Pinteraction = 0.79). In summary, a diet with lower carbohydrate, higher animal fat and protein was significantly associated with higher risk of HCC among Chinese Singaporeans.
Prevention Relevance:
In a large cohort study of more than 63,000 Chinese Singaporeans, we found that a diet with lower carbohydrate and higher animal fat and protein was associated with increased risk of HCC, suggesting that dietary modification could be an effective strategy in primary prevention to reduce the HCC burden.
Data from Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome—A Pilot Study
Authors: Sievänen Tero , Jokela Tiina , Hyvärinen Matti , Korhonen Tia-Marje , Pylvänäinen Kirsi , Mecklin Jukka-Pekka , Karvanen Juha , Sillanpää Elina , Seppälä Toni T. , Laakkonen Eija K.
Published: June 2024

Abstract
Lynch syndrome (LS) is the most common autosomal dominant cancer syndrome and is characterized by high genetic cancer risk modified by lifestyle factors. This study explored whether a circulating miRNA (c-miR) signature predicts LS cancer incidence within a 4-year prospective surveillance period. To gain insight how lifestyle behavior could affect LS cancer risk, we investigated whether the cancer-predicting c-miR signature correlates with known risk-reducing factors such as physical activity, body mass index (BMI), dietary fiber, or NSAID usage. The study included 110 c-miR samples from LS carriers, 18 of whom were diagnosed with cancer during a 4-year prospective surveillance period. Lasso regression was utilized to find c-miRs associated with cancer risk. Individual risk sum derived from the chosen c-miRs was used to develop a model to predict LS cancer incidence. This model was validated using 5-fold cross-validation. Correlation and pathway analyses were applied to inspect biological functions of c-miRs. Pearson correlation was used to examine the associations of c-miR risk sum and lifestyle factors. hsa-miR-10b-5p, hsa-miR-125b-5p, hsa-miR-200a-3p, hsa-miR-3613-5p, and hsa-miR-3615 were identified as cancer predictors by Lasso, and their risk sum score associated with higher likelihood of cancer incidence (HR 2.72, 95% confidence interval: 1.64–4.52, C-index = 0.72). In cross-validation, the model indicated good concordance with the average C-index of 0.75 (0.6–1.0). Coregulated hsa-miR-10b-5p, hsa-miR-125b-5p, and hsa-miR-200a-3p targeted genes involved in cancer-associated biological pathways. The c-miR risk sum score correlated with BMI (r = 0.23, P < 0.01). In summary, BMI-associated c-miRs predict LS cancer incidence within 4 years, although further validation is required.
Prevention Relevance:
The development of cancer risk prediction models is key to improving the survival of patients with LS. This pilot study describes a serum miRNA signature–based risk prediction model that predicts LS cancer incidence within 4 years, although further validation is required.
Supplementary Table S9 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Authors: Jiang Jingjing , Jiang Lingyan , Maldonato Benjamin J. , Wang Yingyun , Holderfield Matthew , Aronchik Ida , Winters Ian P. , Salman Zeena , Blaj Cristina , Menard Marie , Brodbeck Jens , Chen Zhe , Wei Xing , Rosen Michael J. , Gindin Yevgeniy , Lee Bianca J. , Evans James W. , Chang Stephanie , Wang Zhican , Seamon Kyle J. , Parsons Dylan , Cregg James , Marquez Abby , Tomlinson Aidan C.A. , Yano Jason K. , Knox John E. , Quintana Elsa , Aguirre Andrew J. , Arbour Kathryn C. , Reed Abby , Gustafson W. Clay , Gill Adrian L. , Koltun Elena S. , Wildes David , Smith Jacqueline A.M. , Wang Zhengping , Singh Mallika
Published: June 2024

Supplementary Table S9 shows datasets used for PK/Efficacy and PK/PD modeling.
Supplementary Table S6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Authors: Jiang Jingjing , Jiang Lingyan , Maldonato Benjamin J. , Wang Yingyun , Holderfield Matthew , Aronchik Ida , Winters Ian P. , Salman Zeena , Blaj Cristina , Menard Marie , Brodbeck Jens , Chen Zhe , Wei Xing , Rosen Michael J. , Gindin Yevgeniy , Lee Bianca J. , Evans James W. , Chang Stephanie , Wang Zhican , Seamon Kyle J. , Parsons Dylan , Cregg James , Marquez Abby , Tomlinson Aidan C.A. , Yano Jason K. , Knox John E. , Quintana Elsa , Aguirre Andrew J. , Arbour Kathryn C. , Reed Abby , Gustafson W. Clay , Gill Adrian L. , Koltun Elena S. , Wildes David , Smith Jacqueline A.M. , Wang Zhengping , Singh Mallika
Published: June 2024

Supplementary Table S6 shows PK/PD data used to derive PK/PD relationship curves in Fig. 5 and Fig. S5.
Supplementary Table S1 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: June 2024

Table S1. Representativeness of study participants.
Supplementary Appendix from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: June 2024

Supplementary Appendix: additional Methods information
Figure S8 from The ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid Enhances NK-Cell Antitumor Effector Functions
Authors: Wu Shuting , Peng Hongyan , Li Songyang , Huang Lanlan , Wang Xiangyu , Li Yana , Liu Yongjie , Xiong Peiwen , Yang Qinglan , Tian Kunpeng , Wu Weiru , Pu Rongxi , Lu Xiulan , Xiao Zhenghui , Yang Jian , Zhong Zhaoyang , Gao Yuan , Deng Yafei , Deng Youcai
Published: June 2024

Figure. S8. A, Purified splenic NK cells from WT mice were treated with DMSO or 10 μM DHA in the presence of 1000 IU IL-2 plus 10 ng/ml IL-15 or 50 ng/ml IL-15 alone for 10 days and the gMFIs of 2-NBDG were measured in NK cells. B, Purified splenic NK cells (purity ≥ 98.0%) from WT mice were treated with DMSO, 10 μM DHA, 10 μM DHA plus 20 μM SR-18292 or 20 μM SR-18292 in the presence of 50 ng/ml IL-15 for 48 hours and the gMFIs of 2-NBDG were measured in NK cells.
Figure S6 from The ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid Enhances NK-Cell Antitumor Effector Functions
Authors: Wu Shuting , Peng Hongyan , Li Songyang , Huang Lanlan , Wang Xiangyu , Li Yana , Liu Yongjie , Xiong Peiwen , Yang Qinglan , Tian Kunpeng , Wu Weiru , Pu Rongxi , Lu Xiulan , Xiao Zhenghui , Yang Jian , Zhong Zhaoyang , Gao Yuan , Deng Yafei , Deng Youcai
Published: June 2024

Figure. S6 NK cells have high absorption capacity for DHA
Figure S1 from The ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid Enhances NK-Cell Antitumor Effector Functions
Authors: Wu Shuting , Peng Hongyan , Li Songyang , Huang Lanlan , Wang Xiangyu , Li Yana , Liu Yongjie , Xiong Peiwen , Yang Qinglan , Tian Kunpeng , Wu Weiru , Pu Rongxi , Lu Xiulan , Xiao Zhenghui , Yang Jian , Zhong Zhaoyang , Gao Yuan , Deng Yafei , Deng Youcai
Published: June 2024

Figure. S1. The effects of DHA supplementation for three weeks on T, B and NK cells without B16F10 injection. WT mice were fed with control or DHA-enriched diets for three weeks.
Figure S6 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S6: Comparison of long and short read RNA gene expression quantification and transcript coverage bias.
Figure S4 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S4: Overview of somatic mutation statistics for tumor samples analyzed by WGS in this study.
Figure S3 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S3: Identifying FRM0469-dextramer-positive CD8+ T cells.
Figure S2 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S2: Long RNA splice correction, isoform identification, and translation prediction.
Figure S16 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S16: Expansion of FRM-specific CD8T cells after priming with relevant peptide in PBMC from healthy individuals.
Supplementary Figure S5 from An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T Cells and Promotes Tumor Clearance
Authors: Shao Lulu , Srivastava Rashmi , Delgoffe Greg M. , Thorne Stephen H. , Sarkar Saumendra N.
Published: June 2024

Supplementary Figure S5 with legend
Figure S14 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S14: A375 immunopeptidomics.
Supplementary Figure S3 from An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T Cells and Promotes Tumor Clearance
Authors: Shao Lulu , Srivastava Rashmi , Delgoffe Greg M. , Thorne Stephen H. , Sarkar Saumendra N.
Published: June 2024

Supplementary Figure S3 with legend
Supplementary Data File 2 from An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T Cells and Promotes Tumor Clearance
Authors: Shao Lulu , Srivastava Rashmi , Delgoffe Greg M. , Thorne Stephen H. , Sarkar Saumendra N.
Published: June 2024

Treg cells gating strategy
Figure S10 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S10: A) NOP expression compared to normal genes.
Supplementary Data File 1 from An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T Cells and Promotes Tumor Clearance
Authors: Shao Lulu , Srivastava Rashmi , Delgoffe Greg M. , Thorne Stephen H. , Sarkar Saumendra N.
Published: June 2024

Exhausted T cells gating strategy
Figure S1 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S1: RNA-guided tumor genome reconstruction.
Supplemental Figure 5 from Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects
Authors: Menachem Assaf , Alteber Zoya , Cojocaru Gady , Fridman Kfir Tal , Blat Dan , Leiderman Olga , Galperin Moran , Sever Lital , Cohen Nadav , Cohen Keren , Granit Roy Z. , Vols Sandra , Frenkel Masha , Soffer Liron , Meyer Karin , Menachem Keren , Galon Tilleman Hadas , Morein Dina , Borukhov Itamar , Toporik Amir , Perpinial Shahor Michal , Tatirovsky Evgeny , Mizrachi Aviram , Levy-Barda Adva , Sadot Eran , Strenov Yulia , Eitan Ram , Jakobson-Setton Ariella , Yanichkin Natalia , Ferre Pierre , Ophir Eran
Published: June 2024

Supplemental Figure S5. IL-18BP blockade alters the immune infiltrate composition of E0771 tumors.
Supplementary Figure 3 from Intratumoral TREX1 Induction Promotes Immune Evasion by Limiting Type I IFN
Authors: Toufektchan Eléonore , Dananberg Alexandra , Striepen Josefine , Hickling James H. , Shim Abraham , Chen Yanyang , Nichols Ashley , Duran Paez Mercedes A. , Mohr Lisa , Bakhoum Samuel F. , Maciejowski John
Published: June 2024

Frequency of micronucleation and micronuclear envelope rupture are similar across KO models.
Supplementary Figure 5 from The Exonuclease TREX1 Constitutes an Innate Immune Checkpoint Limiting cGAS/STING-Mediated Antitumor Immunity
Authors: Lim Junghyun , Rodriguez Ryan , Williams Katherine , Silva John , Gutierrez Alan G. , Tyler Paul , Baharom Faezzah , Sun Tao , Lin Eva , Martin Scott , Kayser Brandon D. , Johnston Robert J. , Mellman Ira , Delamarre Lélia , West Nathaniel R. , Müller Sören , Qu Yan , Heger Klaus
Published: June 2024

Supplementary Figure 5. TREX1 loss remodels an immunosuppressive myeloid tumor microenvironment
Supplemental Figure 5 from Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer
Authors: Choudhury Atish D. , Kwak Lucia , Cheung Alexander , Allaire Kathryn M. , Marquez Jaqueline , Yang David D. , Tripathi Abhishek , Kilar Jacqueline M. , Flynn Meredith , Maynard Brianna , Reichel Rebecca , Pace Amanda F. , Chen Brandon K. , Van Allen Eliezer M. , Kilbridge Kerry , Wei Xiao X. , McGregor Bradley A. , Pomerantz Mark M. , Bhatt Rupal S. , Sweeney Christopher J. , Bubley Glenn J. , Jacene Heather A. , Taplin Mary-Ellen , Huang Franklin W. , Harshman Lauren C. , Fong Lawrence
Published: June 2024

Kaplan-Meier estimates of time to treatment failure (TTF), radiographic progression-free survival (rPFS), and overall survival (OS) by A. baseline CD4+FoxP3- (effector) proportion above (high) vs. below (low) median. B. baseline CD8+ proportion above vs. below median. C. baseline CD8+ / CD4+FoxP3+ (Treg) ratio above vs. below median. N.B. Patients were event-free for 2 months as they need to have on treatment biopsy at week 8 of treatment.
Supplemental Figure 3 from Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer
Authors: Choudhury Atish D. , Kwak Lucia , Cheung Alexander , Allaire Kathryn M. , Marquez Jaqueline , Yang David D. , Tripathi Abhishek , Kilar Jacqueline M. , Flynn Meredith , Maynard Brianna , Reichel Rebecca , Pace Amanda F. , Chen Brandon K. , Van Allen Eliezer M. , Kilbridge Kerry , Wei Xiao X. , McGregor Bradley A. , Pomerantz Mark M. , Bhatt Rupal S. , Sweeney Christopher J. , Bubley Glenn J. , Jacene Heather A. , Taplin Mary-Ellen , Huang Franklin W. , Harshman Lauren C. , Fong Lawrence
Published: June 2024

Swimmer’s plot of treatments received. Number of radium-223 and pembrolizumab doses received are listed to the left and right of the bars, respectively. The brackets “[” and “]” represent the planned break period from radium-223 dosing with “[” representing cycle 3 day 28 and “]” representing cycle 4 day 1 when the interval between these was greater than 28 days. Patients could resume radium treatment at radiographic progression by PCWG2 criteria (“△”) if there were no new visceral metastases, but two patients (bars 7 and 13 below) resumed without confirmed radiographic progression.
Supplemental Figure 2 from Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer
Authors: Choudhury Atish D. , Kwak Lucia , Cheung Alexander , Allaire Kathryn M. , Marquez Jaqueline , Yang David D. , Tripathi Abhishek , Kilar Jacqueline M. , Flynn Meredith , Maynard Brianna , Reichel Rebecca , Pace Amanda F. , Chen Brandon K. , Van Allen Eliezer M. , Kilbridge Kerry , Wei Xiao X. , McGregor Bradley A. , Pomerantz Mark M. , Bhatt Rupal S. , Sweeney Christopher J. , Bubley Glenn J. , Jacene Heather A. , Taplin Mary-Ellen , Huang Franklin W. , Harshman Lauren C. , Fong Lawrence
Published: June 2024

Consort diagram for status of trial. Progression (PD) includes protocol defined progression and clinical/symptomatic progression per physician.
Figure S6 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
Authors: Mikami Hirofumi , Feng Shu , Matsuda Yutaka , Ishii Shinya , Naoi Sotaro , Azuma Yumiko , Nagano Hiroaki , Asanuma Kentaro , Kayukawa Yoko , Tsunenari Toshiaki , Kamikawaji Shogo , Iwabuchi Ryutaro , Shinozuka Junko , Yamazaki Masaki , Kuroi Haruka , Ho Samantha Shu Wen , Gan Siok Wan , Chichili Priyanka , Pang Chai Ling , Yeo Chiew Ying , Shimizu Shun , Hironiwa Naoka , Kinoshita Yasuko , Shimizu Yuichiro , Sakamoto Akihisa , Muraoka Masaru , Takahashi Noriyuki , Kawa Tatsuya , Shiraiwa Hirotake , Mimoto Futa , Kashima Kenji , Kamata-Sakurai Mika , Ishikawa Shumpei , Aburatani Hiroyuki , Kitazawa Takehisa , Igawa Tomoyuki
Published: June 2024

Supplementary Figure S6. Cross-reactivity of DLL3 trispecific.
Figure S4 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
Authors: Mikami Hirofumi , Feng Shu , Matsuda Yutaka , Ishii Shinya , Naoi Sotaro , Azuma Yumiko , Nagano Hiroaki , Asanuma Kentaro , Kayukawa Yoko , Tsunenari Toshiaki , Kamikawaji Shogo , Iwabuchi Ryutaro , Shinozuka Junko , Yamazaki Masaki , Kuroi Haruka , Ho Samantha Shu Wen , Gan Siok Wan , Chichili Priyanka , Pang Chai Ling , Yeo Chiew Ying , Shimizu Shun , Hironiwa Naoka , Kinoshita Yasuko , Shimizu Yuichiro , Sakamoto Akihisa , Muraoka Masaru , Takahashi Noriyuki , Kawa Tatsuya , Shiraiwa Hirotake , Mimoto Futa , Kashima Kenji , Kamata-Sakurai Mika , Ishikawa Shumpei , Aburatani Hiroyuki , Kitazawa Takehisa , Igawa Tomoyuki
Published: June 2024

Supplementary Figure S4. DLL3 trispecific induces multiple cytokine production and DLL3-
dependent cytotoxicity
Figure S2 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
Authors: Mikami Hirofumi , Feng Shu , Matsuda Yutaka , Ishii Shinya , Naoi Sotaro , Azuma Yumiko , Nagano Hiroaki , Asanuma Kentaro , Kayukawa Yoko , Tsunenari Toshiaki , Kamikawaji Shogo , Iwabuchi Ryutaro , Shinozuka Junko , Yamazaki Masaki , Kuroi Haruka , Ho Samantha Shu Wen , Gan Siok Wan , Chichili Priyanka , Pang Chai Ling , Yeo Chiew Ying , Shimizu Shun , Hironiwa Naoka , Kinoshita Yasuko , Shimizu Yuichiro , Sakamoto Akihisa , Muraoka Masaru , Takahashi Noriyuki , Kawa Tatsuya , Shiraiwa Hirotake , Mimoto Futa , Kashima Kenji , Kamata-Sakurai Mika , Ishikawa Shumpei , Aburatani Hiroyuki , Kitazawa Takehisa , Igawa Tomoyuki
Published: June 2024

Supplementary Figure S2. Overview of the generation of the CD3/CD137 dual-specific Fab
Data from Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects
Authors: Menachem Assaf , Alteber Zoya , Cojocaru Gady , Fridman Kfir Tal , Blat Dan , Leiderman Olga , Galperin Moran , Sever Lital , Cohen Nadav , Cohen Keren , Granit Roy Z. , Vols Sandra , Frenkel Masha , Soffer Liron , Meyer Karin , Menachem Keren , Galon Tilleman Hadas , Morein Dina , Borukhov Itamar , Toporik Amir , Perpinial Shahor Michal , Tatirovsky Evgeny , Mizrachi Aviram , Levy-Barda Adva , Sadot Eran , Strenov Yulia , Eitan Ram , Jakobson-Setton Ariella , Yanichkin Natalia , Ferre Pierre , Ophir Eran
Published: June 2024

Abstract
Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory cytokine, which enhances T- and NK-cell activity and stimulates IFNγ production. The activity of IL18 is naturally blocked by a high-affinity endogenous binding protein (IL18BP). IL18BP is induced in the tumor microenvironment (TME) in response to IFNγ upregulation in a negative feedback mechanism. In this study, we found that IL18 is upregulated in the TME compared with the periphery across multiple human tumors and most of it is bound to IL18BP. Bound IL18 levels were largely above the amount required for T-cell activation in vitro, implying that releasing IL18 in the TME could lead to potent T-cell activation. To restore the activity of endogenous IL18, we generated COM503, a high-affinity anti-IL18BP that blocks the IL18BP:IL18 interaction and displaces precomplexed IL18, thereby enhancing T- and NK-cell activation. In vivo, administration of a surrogate anti-IL18BP, either alone or in combination with anti-PD-L1, resulted in significant tumor growth inhibition and increased survival across multiple mouse tumor models. Moreover, the anti-IL18BP induced pronounced TME-localized immune modulation including an increase in polyfunctional nonexhausted T- and NK-cell numbers and activation. In contrast, no increase in inflammatory cytokines and lymphocyte numbers or activation state was observed in serum and spleen. Taken together, blocking IL18BP using an Ab is a promising approach to harness cytokine biology for the treatment of cancer.
Supplementary figure 3 from B7-H3–Targeting Chimeric Antigen Receptors Epstein-Barr Virus–specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3–positive Solid Tumors
Authors: Yeo Siok Ping , Kua Lindsay , Tan Jin Wei , Lim Joanna Kristyn , Wong Fiona HS , Santos May Delos , Poh Chek Meng , Goh Angeline XH , Koh Xin Yu , Zhou Xiaohua , Rajarethinam Ravisankar , Chen Qingfeng , Her Zhisheng , Horak Ivan D. , Low Lionel , Tan Kar Wai
Published: June 2024

Supplementary figure 3
FIGURE 2 from B7-H3–Targeting Chimeric Antigen Receptors Epstein-Barr Virus–specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3–positive Solid Tumors
Authors: Yeo Siok Ping , Kua Lindsay , Tan Jin Wei , Lim Joanna Kristyn , Wong Fiona HS , Santos May Delos , Poh Chek Meng , Goh Angeline XH , Koh Xin Yu , Zhou Xiaohua , Rajarethinam Ravisankar , Chen Qingfeng , Her Zhisheng , Horak Ivan D. , Low Lionel , Tan Kar Wai
Published: June 2024

The P2A5 VHH binds to human and mouse B7-H3. SPR multi-cycle kinetic analysis of P2A5 binding to the 4-Ig (A) and 2-Ig (B) human B7-H3 isoforms, and to mouse B7-H3 (C). D, Binding kinetic parameters of P2A5 binding to the B7-H3 variants in A–C. E, Representative fluorescence microscopy images of P2A5 binding to human and mouse B7-H3. B7-H3–negative murine CT26 cells and human MKN7 cells knocked out for endogenous B7-H3 were transfected to express either murine B7-H3 or human 4-Ig B7-H3 and stained with positive control anti-mouse or anti-human B7-H3 antibodies, P2A5 as a VHH-Fc fusion molecule, or isotype control. GFP expression was used as an indicator of successful transfection.
A new airfield lighting system network architecture
Authors: Derraa Amine , Ouaaline Najat , Nassiri Boujemaa
Published: June 2024

Airport navigation lights are essential for safe night and adverse weatherflying. Airfield ground lighting (AGL) systems providevisual guidanceduring airport operations. These systems use multiple lamps connected inseries with constant current regulators (CCRs) to provide power. Promptdetection and location of failed lamps are critical to airport efficiency andcost savings. Local area network (LAN) communication facilitates lampmonitoring and control, improving system performance and reducingmaintenance costs. Effective transmission media are critical for systemreliability and efficiency. This article presents a new network architecturefor AGL systems that connects lamps and the control system using a newintelligent module; this architecture combines star and bus topologies in ahybrid intranet network. The obtained results show excellent networkingperformances by means oflatency and throughput. This architectureimproves operational efficiency and reduces maintenance for AGL systems.
Power efficiency improvement in reactive power dispatch under load uncertainty
Authors: Agouzoul Naima , Oukennou Aziz , Elmariami Faissal , Boukherouaa Jamal , Gadal Rabiaa
Published: June 2024

Nowadays, there is a significant rise in electricity demand, posing challenges for power grid operators due to inaccurate forecasting, leading to excessive power losses and voltage instability. This paper addresses these issues by focusing on solving optimal reactive power dispatch (ORPD) while considering load demand uncertainty. The main objective of solving ORPD is to reduce power losses by adjusting generator voltage ratings, transformer tap ratio, and shunt capacitors' reactive power. Monte Carlo simulation (MCS) is employed to generate load scenarios using the normal probability density function, while a reduction-based technique is implemented to decrease the number of those scenarios. The improved gray wolf optimization (I-GWO) algorithm is introduced for the first time to address the stochastic ORPD problem. Experimentation is conducted on an IEEE-30 bus system when results are contrasted with conventional gray wolf optimization (GWO) and five other algorithms as stated in the literature. The I-GWO algorithm's performance is assessed with and without considering load demand uncertainty. Through Friedman's statistical tests, a significant decrease of 20.96% in active power losses and 63.06% in the summation of expected power losses is observed. The I-GWO algorithm's results on the ORPD problem demonstrate its effectiveness and robustness.
Enhancing efficiency in capacitive power transfer: exploring gap distance and load robustness
Authors: Yusop Yusmarnita , Cheok Yan Qi , Saat Shakir , Husin Huzaimah
Published: June 2024

In this paper, the capacitive power transfer (CPT) technology is used as an alternative to inductive power transfer (IPT). CPT relies on electric fields that are not sensitive to the presence of any metals, utilizes metal electrodes for power transfer, and is less bulky compared to IPT. The proposed CPT system utilizes a Class-E resonant inverter with a double-sided inductor-capacitor (LC) matching circuit which operates at an optimum load, with a duty cycle, D=0.5 to gain an output power, W and efficiency, η=84.6%. The proposed CPT system enhances the system’s efficiency as compared to the past research while preserving the zero-voltage switching (ZVS) condition within a wider load range from 50 Ω to 1,316 Ω. This paper also shows that the proposed CPT system is less sensitive to load and coupling variations. Finally, the rate of power dissipated at varied load resistances, has been derived successfully to determine the sensitivity level of the proposed CPT systems toward load variations. These equations are then validated by plotting the efficiency graphs based on load and coupling variations.
Energy efficient improved content addressable memory using quantum-dot cellular automata
Authors: Kotte Sujatha , Kanaka Durga Ganapavarapu
Published: June 2024

Quantum-dot cellular automata (QCA) is an emerging technology with high integration density, low power consumption, and high operating speed. This study introduces a QCA-based modified content addressable memory (CAM) cell employing a five-input minority gate. The functionality, temperature sensitivity, and heat distribution of this modified CAM cell are comprehensively analyzed using QCADesigner E and QCA Pro simulation tools. The results reveal significant advancements over existing designs, with a remarkable 8.33% reduction in area and a substantial 63.7% decrease in energy consumption. Additionally, this modified CAM cell exhibits a notable 5% enhancement in temperature tolerance. These findings emphasize the QCA-based modified CAM cell is more efficient and thermally robust.
Field-programmable gate array implementation of efficient deep neural network architecture
Authors: Kumar Reddy Pottipati Dileep , Ramanaiah Kota Venkata
Published: June 2024

Deep neural network (DNN) comprises multiple stages of data processing sub-systems with one of the primary sub-systems is a fully connected neural network (FCNN) model. This fully connected neural network model has multiple layers of neurons that need to be implemented using arithmetic units with suitable number representation to optimize area, power, and speed. In this work, the network parameters are analyzed, and redundancy in weights is eliminated. A pipelined and parallel structure is designed for the fully connected network information. The proposed FCNN structure has 16 inputs, 3 hidden layers, and an output layer. Each hidden layer consists of 4 neurons and describes how the inputs are connected to hidden layer neurons to process the raw data. A hardware description language (HDL) model is developed for the proposed structure and the verified model is implemented on Xilinx field-programmable gate array (FPGA). The modified structure comprises registers, demultiplexers, weight registers, multipliers, adders, and read-only memory lookup table (ROM/LUT). The modified architecture implemented on FPGA is estimated to reduce area by 87.5% and improve timing by 3x compared with direct implementation methods.
Intermittent open-circuit fault diagnosis of inverters based on DC-link electromagnetic field signal
Authors: Vu Hoang-Giang , Yahoui Hamed
Published: June 2024

For the objective of improving the reliability of converters in electric drives, research on a method for early detection of intermittent open-circuit faults of power valves is reported in this article. Intermittent open circuit condition is the incipient form of power valve open-circuit fault in power converters. Prompt detection of this fault allows for timely remediation of permanent open circuit defects that is a commonly subsequent process. This study introduces an investigation of this fault, which occurs in the voltage source inverter of induction motor drives. Intermittent faults are created through interference with the control pulse of the power valve. Wavelet transform with the Mexican hat mother function is utilized for signal processing. Appropriate ranges of the scale are selected to obtain a high magnitude of the wavelet coefficient at faulty instants. The analysis for the direct current recorded at the DC-link in simulation and the electromagnetic signal measured at the DC-bus of the inverter can be effectively used for the fault diagnosis.
Internet of things-based electrical energy control and monitoring in households using spreadsheet datalogger
Authors: Jannah Misbahul , Hasibuan Arnawan , Kartika Kartika , Asran Asran , Yunizar Zara , Usrina Nura , Nuryawan Nuryawan , Almunadiansyah Rizky
Published: June 2024

Today, the demand for electrical energy is paramount in various daily activities. Hence, individuals must be aware of the amount of electrical energy consumed to maintain the quality of electronic devices. Knowing the quality of electronic devices is essential since it can impact the performance and lifespan of electrical equipment. The value of electrical power is determined by the quality of electrical power and the number of hours. Monitoring electrical energy involves collecting or measuring data to assess the current level of energy consumption. The author is interested in researching the use of Datalogger Spreadsheets to monitor and gather real-time information on energy use, which is made possible through integration with internet of things (IoT) and microcontrollers. Through data analysis and observation, solutions to existing problems are sought by comparing and matching data. Monitoring daily energy usage in a home setting produces output data that can be viewed directly and remotely with real-time results. This tool is expected to address current issues.
Optimizing drone-assisted victim localization and identification in mass-disaster management: a study on feasible flying patterns and technical specifications
Authors: Azmi Intan Nabina , Kassim Murizah , Mohd Yussoff Yusnani , Md Tahir Nooritawati
Published: June 2024

The prompt emphasizes the importance of identifying victims in a disaster area within 48 hours and highlights the potential benefits of using drones in search and rescue missions. However, the use of drones is limited by factors such as battery life, processing speed, and communication range. To address these limitations, the paper presents a detailed research study on the most effective flying pattern for drones during search and rescue missions. The study utilized energy consumption and coverage area as performance metrics and collected precise images that could be analyzed by the forensic team. The research was conducted using OMNET++ and fieldwork at Pulau Sebang, Melaka, in collaboration with search and rescue agencies in Malaysia. The results suggest that the square flying pattern is the most effective, as it provides the highest coverage area with reasonable energy utilization. Both simulation and fieldwork results showed coverage of 100% and 97.96%, respectively, for this pattern. Additionally, the paper provides technical specifications for rescue teams to use when deploying drones during search and rescue missions.
Fine-tuning ResNet-50 for the classification of visual impairments from retinal fundus images
Authors: Imaduddin Helmi , Utomo Ihsan Cahyo , Anggoro Dimas Aryo
Published: June 2024

The sense of sight plays a crucial role in human perception, as it serves as our primary sensory organ for perceiving light. However, a considerable number of individuals experience a wide range of vision impairments. These impairments encompass diverse conditions such as diabetic retinopathy, glaucoma, and cataracts. Each visual impairment exhibits unique characteristics and symptoms, highlighting the need for timely and accurate detection to facilitate appropriate treatment and prevent vision loss. This research aims to develop a deep learning-based system specifically designed to detect visual impairments. The proposed solution involves creating a model using the ResNet-50 algorithm as the foundational methodology, and fine-tuning multiple parameters to enhance the model's performance. The research utilizes a dataset consisting of retinal fundus images, which are categorized into four distinct classes: diabetic retinopathy, glaucoma, cataracts, and normal. The findings demonstrate the effectiveness of the model, achieving an impressive accuracy score of 92%. This signifies a significant improvement of 6% over the accuracy achieved in the previous study, which stood at 86%. The implementation of this system is expected to make a significant contribution to the rapid and accurate detection of various eye disorders in the future, enabling timely intervention and prevention of visual impairment.
AlgoDM: algorithm to perform aspect-based sentiment analysis using IDistance matrix
Authors: Savanur Sandhya Raghavendra , Ranganathaiah Sumathi , Srinivasamurthy Shreedhara Kondajji
Published: June 2024

Sentiment analysis is a method of analyzing data to identify its intent. It identifies the emotional tone of a text body. Aspect-based sentiment analysis is a text analysis technique that identifies the aspect and the sentiment associated with each aspect. Different organizations use aspect-based sentiment analysis to analyze opinions about a product, service, or idea. Traditional sentiment analysis methods analyze the complete text and assign a single sentiment label to it. They do not handle the tasks of aspect association, dealing with multiple aspects and inclusion of linguistic concepts together as a system. In this article, AlgoDM, an algorithm to perform aspect-based sentiment analysis is proposed. AlgoDM uses a novel concept of IDistance matrix to extract aspects, associate aspects with sentiment words, and determine the sentiment associated with each aspect. The IDistance matrix is constructed to calculate the distance between aspects and the words expressing the sentiment related to the aspect. It works at the sentence level and identifies the opinion expressed on each aspect appearing in the sentence. It also evaluates the overall sentiment expressed in the sentence. The proposed algorithm can perform sentiment analysis of any opinionated text.