bluuebunny/crossref_metadata_2025 huggingface dataset:
Lesão Tumoral Primária do Pulmão em Adolescente
Authors: Rodrigues Luís , Domingues Rui , Amaral Diana , Cavaco José
Published: January 2020

Os tumores pulmonares primários em idade pediátrica são raros, existindo, contudo, uma multiplicidade de tipos histológicos, com diferentes abordagens terapêuticas. O tumor miofibroblástico inflamatório do pulmão representa 0,04% - 1,2% de todos os tumores pulmonares, é mais frequente em crianças e adultos jovens e a sua etiologia é desconhecida. A apresentação clínica e radiológica é muito variável, pelo que o diagnóstico é difícil. Descrevemos o caso de um adolescente de 15 anos, com achado de nódulo pulmonar em radiografia de tórax realizada no contexto de infeção respiratória e cujo estudo etiológico revelou tratar-se de um tumor miofibroblástico inflamatório do pulmão. Foi realizada resseção atípica por toracoscopia videoassistida, verificando-se evolução favorável. Salientamos a raridade desta entidade, a necessidade de elevado índice de suspeição clínica e a marcha diagnóstica que levou ao esclarecimento definitivo e à sua resolução.
Interdisciplinaridade e formação docente
Authors: Hahn Alexandre José , Centenaro Junior Bufon
Published: January 2020

Pesquisar sobre uma temática de tamanha envergadura e polissemia como a interdisciplinaridade não é uma tarefa simples, ainda mais quando ela está se constituindo em um campo de conhecimento próprio. Sendo assim, tocar no assunto exige cautela e rigorosidade intelectual, visto que a interdisciplinaridade não se resume apenas a uma ponte entre saberes como comumente é acatada. Não é uma questão de deslocamento, mas de vinculação, de atitude, de um olhar cruzado entre o que se sabe e o que sepode aprender com outros sujeitos e outros saberes; em sua gênese, podemos explicitar que a interdisciplinaridade “busca uma nova forma de compreensão a respeito do conhecimento e sua produção” (p. 11).
Perfis femininos no romance A maçã no escuro, de Clarice Lispector
Authors: Almeida Marília Murta de
Published: January 2020

Este artigo propõe uma análise das figuras femininas no romance A maçã no escuro, de Clarice Lispector. Tal análise busca explicitar o modo como as personagens femininas se relacionam com o protagonista Martim, trazendo à luz estruturas marcadamente conhecidas socialmente como “lugares” femininos, formas típicas de expressão e de dominação da mulher, assim como a saída vislumbrada pelo desenlace do texto para tal situação.
Ciência e subjetividade na perspectiva de Hilton Japiassu
Authors: Oliveira Vanessa Sousa de
Published: January 2020

As transformações epistemológicas que presenciamos nos últimos cinquenta anos, fundamentadas no questionamento ao Positivismo, alteraram profundamente o modo de pensar a relação entre ciência e subjetividade. Nesse contexto, cabe perguntar como essa relação é abordada nas Ciências Humanas/Sociais. O ensaio discorre sobre como as Epistemologias da Subjetividade se apresentam diante dessa relação, qual o papel social delegado ao cientista, sujeito e objeto de suas próprias práticas, e como a discussão é abordada pelo filósofo Hilton Japiassu.
Educação formal, não-formal e Hip Hop contextos e desafios educacionais no Brasil e Cabo Verde
Authors: Mafra Vitor
Published: January 2020

O modelo escolar moderno que foi universalizado durante o século XX, mostrou-se incapacitado de responder todas as demandas sociais que lhe foram impostas. Dessa forma, durante a segunda metade deste século a crise do sistema de ensino formal deu abertura a diversos debates sobre questões que permeiam a ação de educar, como os espaços, os atores e porque não sobre próprio conceito: o que é educar? Sendo assim, neste artigo trago reflexões sobre a educação formal, dentre outras formas, analisando o contexto da educação no Brasil e em Cabo Verde, para compreender de que maneira determinados atores sociais, como os rappers, podem contribuir para a construção de uma educação emancipadora.
La influencia del espacio, la ciudad y la Cultura Maker en educación = The influence of space, the city and maker culture in education
Authors: Garcia Rodriguez Yolanda , Carrascal Domínguez Silvia
Published: January 2020

ResumenEn el desarrollo del presente texto se muestra una reflexión sobre la in-fluencia que ejercen los espacios y la cultura Maker en la educación. En este sen-tido, la educación se convierte en el vínculo de transmisión de culturas y la escuela se presenta como un lugar privilegiado para el desarrollo de aprendizajes y rela-ciones en espacios de gran diversidad que den respuesta a las demandas sociales. Las nuevas generaciones se forman en un contexto educativo que da mucha im-portancia a las Tecnologías de la Información y la Comunicación, las cuales trans-miten nuevos valores de colaboración y respeto, a través del diseño de nuevos espacios de aprendizaje e intercambio de experiencias. En este sentido, la escuela puede servir para compensar desigualdades y adquirir nuevos conocimientos com-partidos con personas de todo el mundo, favoreciendo entornos de interacción entre los diferentes sistemas sociales, culturales y educativos.AbstractIn the development of this text reflects on the influence spaces and Maker culture in education. In this sense, education becomes the transmission link cul-tures and the school is presented as a privileged place for the development of learning and relationships in areas of great diversity that respond to social de-mands. The new generations are formed in an educational context that gives great importance to information and communications technology, which transmit new values of cooperation and respect, through the design of new spaces for learning and sharing of experiences. In this sense, the school can serve to offset inequali-ties and acquire new shares with people around the world, promoting environments interaction between different social, cultural and education systems.
A RESPOSTA DOS ESPECTADORES DO YOUTUBE A PROPAGANDAS INTEGRADAS AO CONTEÚDO DE VÍDEOS: um estudo netnográfico
Authors: Corso Kathiane Benedetti , Barcellos Matheus de Mello
Published: January 2020

O presente artigo tem por objetivo analisar a resposta de usuários do YouTube à existência de propaganda inserida dentro do conteúdo de vídeosPara se chegar a tal objetivo foi realizada uma pesquisa exploratória e qualitativa através do método netnográfico. Como principais resultados foi observado que existem cinco modelos utilizados pelos produtores de conteúdo para a inserção de propagandas no conteúdo de vídeos. Os modelos com maior resposta por parte dos usuários foram aqueles que apresentavam o produto por um período maior de tempo. Sendo que as propagandas que apresentaram uma resposta mais positiva dos usuários foram aquelas que geraram informação, entretenimento ou eram customizadas para o público que as assistiram.

 

PALAVRAS-CHAVE: YouTube; Propaganda; Netnografia.

 

 

ABSTRACT

This article purpose to analyze the response of YouTube users to advertisement inserted within the content of videos. To reach this aim, an exploratory and qualitative research was carried out through the netnographic method. As main results it was perceived that there are five models used by content producers for the insertion of advertisements in the content of videos. The models with the highest response from users were those who presented the product for a longer period of time. Since the advertisements that presented a more positive response from the users were those that generated information, entertainment or were customized for the audience that attended them.

 

KEYWORDS: YouTube; Advertising; Netnography.

 

 

RESUMEN

El presente artículo tiene como objetivo analizar la respuesta de usuarios de YouTube a propagandas insertadas em el contenido de videos. Para llegar a tal objetivo se realizó una investigación exploratoria y cualitativa por médio del método netnográfico. Como principales resultados se observó que existen cinco modelos utilizados por los productores de contenido para la inserción de propagandas en el contenido de los vídeos. Los modelos con más respuesta por parte de los usuarios fueron aquellos que presentaban el producto por un período mayor de tiempo. Siendo que las propagaciones que presentaron una respuesta más positiva de los usuarios fueron aquellas que generaron información, entretenimiento o eran personalizadas al público que las asistieron.

 

PALABRAS CLAVE: YouTube; publicidad; Netnografía.
PERCEPÇÕES SOBRE CIBERESPAÇO E TERRITORIALIDADE DIGITAL: estudo exploratório com foco em aspectos socioculturais presentes na deep web e dark web
Authors: Nogueira Cássio Cipriano , Vas Braz Batista
Published: January 2020

Aquilo que muitos conhecem popularmente como Internet, caracteriza-se, socioculturalmente como ciberespaço e possui territorialidade própria, bem como suas próprias práticas culturais, identificadas como cibercultura. Tendo em vista que, para trazer à luz percepções fundamentais acerca de determinados territórios faz-se necessário analisá-los sob diferentes óticas, contemplando dimensões tais como a política, a econômica, a social e a cultural, este artigo tem como objetivo a realização de um estudo exploratório sobre a territorialidade digital do ciberespaço, por meio de pesquisa bibliográfica e análise de conteúdo, de modo a examinar e destacar aspectos socioculturais a partir das alterações promovidas pela Web 2.0 e percepções sobre as frações do ciberespaço designadas genericamente de Deep Webe Dark Web.
VALIDAÇÃO DE VÍDEO LÚDICO: educação em saúde de idosos hipertensos para a promoção do uso correto e seguro de medicamentos e conhecimento sobre sua doença
Authors: MIRANDA CAROLINA GALGANE LAGE , SOARES-SOBRINHO JOS´E LAMARTINE , Castro Mauro Silveira
Published: January 2020

A utilização do vídeo “Uma história ImPRESSÃOnante”  como ferramenta de educação em saúde para idosos hipertensos, a fim de determinar o ganho de conhecimento entre grupo controle (recebeu palestra tradicional) e grupo intervenção (assistiu ao vídeo). O vídeo produzido teve o objetivo de desenvolver o uso correto e seguro de medicamentos e promover o conhecimento sobre hipertensão e práticas não farmacológicas para tratamento da doença. Métodos: Foi realizado um quase-experimento para avaliação do ganho de conhecimento significativo antes e depois da palestra ou vídeo. A análise dos resultados realizou-se com o teste de normalidade Shapiro-Wilks e ANOVA para ambos os grupos: Controle (N=16) e Intervenção (N=17) e internamente no mesmo grupo. Cada grupo contou com idosos pertencentes ao grupo HiperDia dos Centro de Saúde da Comunidade (CSC) municipais, sorteados aleatoriamente, pertencente a cidade de Palmas, capital do Tocantins. Resultados: Os valores da diferença de médias encontrado para o Grupo Controle e o Grupo intervenção antes e depois da aplicação da palestra ou vídeo, foi significativa  para intervalo de confiança de 95%. Indicando que as médias encontradas no pré e pós teste dentro do mesmo grupo (p=0,00), bem como a diferença entre as médias encontradas entre os grupo (p=0,001) foi estatisticamente significativa. O teste ANOVA comparou o ganho de conhecimento entre os grupos Controle (p=0,019) e intervenção (p=0,000). O grupo Intervenção teve maior ganho de conhecimento (0,8 pontos na média) que no Grupo Controle  (0,2 pontos). Conclusão: Os resultados encontrados levam a conclusão de que o vídeo é uma ferramenta que promove ganho de conhecimento em comparação à metodologia padrão de transferência de conhecimento (palestra).
AS DIFICULDADES DE LICENCIANDOS COM O USO DE MATERIAIS AUTORAIS DIGITAIS EDUCACIONAIS
Authors: Lima Luciana de
Published: January 2020

O objetivo da pesquisa é analisar quais são as dificuldades que os licenciandos da disciplina Tecnodocência ofertada no primeiro semestre de 2019 apresentam em relação à utilização de Materiais Autorais Digitais Educacionais (MADEs). A pesquisa qualitativa de caráter exploratório, investiga cinco grupos interdisciplinares formados por licenciandos de diferentes áreas do conhecimento. Os dados foram coletados a partir dos roteiros e dos MADEs propriamente ditos. Diante de uma análise interpretativa, constatou-se que os licenciandos, ao utilizarem tecnologia digital, trouxeram o aluno para o centro do processo de ensino, aprendizagem e avaliação; apresentaram dificuldades em relacionar os conteúdos de diferentes áreas de forma interdisciplinar.
A DEMOCRACIA SEM FIM
Authors: Pierini Alexandre
Published: January 2020

A obra de Leitsky e Ziblatt é mais uma chega ao mercado editorial brasileiro na ânsia de tentar traduzir em palavras o significado da eleição de Donald Trump. Na visão dos autores, as regras políticas americanas se afrouxaram nos últimos anos, a sociedade americana "perdeu" sua reserva política, assim como a responsabilização do Partido Republicano  são alguns dos argumentos utilizados pelos autores no sentido de explicar o porque um lider como Trump ascendeu ao poder.
POR UMA AVALIAÇÃO DA APRENDIZAGEM COMO ATO AMOROSO: 50 anos da oficina pedagógica de Cipriano Luckesi
Authors: Soares Fagno da Silva
Published: January 2020

Entrevista realizada durante o X Encontro Técnico-Pedagógico IFMA/Campus Açailândia em 23 de janeiro de 2019, com o teórico da educação Cipriano Carlos Luckesi, professor aposentado da Faculdade de Filosofia e do Programa de Pós-Graduação em Educação da Faculdade de Educação da Universidade Federal da Bahia (UFBA). Destacado teórico nos estudos em Avaliação da Aprendizagem Escolar há 5 décadas de reflexões seminais sobre o tema. Durante a entrevista, o teórico Cipriano Luckesi falou de sua trajetória profissional, e fez reflexões acerca da avaliação da aprendizagem como ato pedagógico, passando pela avaliação como ato amoroso, a distinção entre avaliar e examinar até o processo de consolidação dos estudos em Avaliação da Aprendizagem no Brasil. Por fim, tratou dos desafios da educação para o professor do século XXI, bem como, das trajetórias, experiências e perspectivas da Avaliação da Aprendizagem Escolar.
Tissue Location Drives the Metabolic Re-Profiling of Macrophages
Authors: Bouchery Tiffany , Coakley Gillian , Harris Nicola
Published: January 2020

That metabolic phenotype can dictate the function of macrophages has been widely demonstrated in vitro, however in vivo relevance of these findings has been lacking. Sverdberg et al., observe that the in vivo microenvironment shapes the ability of macrophages to utilize glucose and thus affects their responsiveness to stimuli.
Entropy, Information and Symmetry, Ordered is Symmetrical, II: System of Spins in the Magnetic Field
Authors: Bormashenko Edward
Published: January 2020

Abstract: The second part of the paper develops the approach, suggested in the Entropy 2020, 22(1), 11; https://doi.org/10.3390/e22010011 , which relates ordering in physical systems to their symmetrizing. Entropy is frequently interpreted as a quantitative measure of “chaos” or “disorder”. However, the notions of “chaos” and “disorder” are vague and subjective to a much extent. This leads to numerous misinterpretations of entropy. We propose to see the disorder as an absence of symmetry and to identify “ordering” with symmetrizing of a physical system; in other words, introducing the elements of symmetry into an initially disordered physical system. We explore the initially disordered system of elementary magnets exerted to the external magnetic field H ⃗. Imposing symmetry restrictions diminishes the entropy of the system and decreases its temperature. The general case of the system of elementary magnets demonstrating the j-fold symmetry is treated. The interrelation T_j=T/j takes place, where T and T_j are the temperatures of non-symmetrized and j-fold-symmetrized systems of the magnets correspondingly.
Patient Derived Models to Study Head and Neck Cancer Radiation Response
Authors: Cosper Pippa F. , Abel Lindsey , Lee Yong-Syu , Paz Cristina , Kaushik Saakshi , Nickel Kwangok P. , Alexandridis Roxana , Scott Jacob G. , Bruce Justine Y. , Kimple Randall J.
Published: January 2020

Patient derived model systems are important tools for studying novel anti-cancer therapies. Patient derived xenografts (PDXs) have gained favor over the last 10 years as newer mouse strains have improved the success rate of establishing PDXs from patient biopsies. PDXs can be engrafted from head and neck cancer (HNC) samples across a wide range of cancer stages, retain the genetic features of their human source, and can be treated with both chemotherapy and radiation, allowing for clinically relevant studies. Not only do PDXs allow for study of patient tissues in an in vivo model, they can also provide a renewable source of cancer cells for organoid cultures. Herein, we review the uses of HNC patient derived models for radiation research including approaches to establishing both orthotopic and heterotopic PDXs, approaches and potential pitfalls to delivering chemotherapy and radiation to these animal models, biological advantages and limitations, and alternatives to animal studies that still use patient-derived tissues.
Acute Effect of Moderate Dose Fructose in Solid Foods on Triglyceride, Glucose and Uric Acid before and after a One-Month Moderate Sugar Feeding Period - A Randomised Controlled Trial
Authors: Clifton Peter M. , Keogh Jennifer B.
Published: January 2020

Fructose in beverages has adverse effects on lipids, glucose and insulin sensitivity after acute and chronic ingestion. There is limited data showing that chronic consumption of fructose in solid foods has harmful effects. We hypothesized that a moderate amount of fructose compared with sucrose in solid food consumed for a month would not adversely influence fasting or postprandial lipids and glucose after an acute fat and carbohydrate load. Twenty-five men and women with prediabetes and/or obesity and overweight consumed in random order two acute test meals of muffins sweetened with either fructose or sucrose, followed by 4-week chronic consumption of 42g/day of either fructose or sucrose in low fat muffins after which the 2 meal tests were repeated. Subjects were randomised to sugar type in the chronic feeding period. Sugar type had no effect on the incremental area under the curve for triglyceride or uric acid at either time point (P=0.4 and P=0.9). There was no overall difference between meal tests at baseline and after 1 month and no effect of consuming sucrose or fructose muffins for 1 month. Fasting triglyceride increased after chronic consumption of fructose by 0.31±0.37 mmol/L compared with sucrose in people with IFG/IGT only (P=0.004). Fructose at a moderate intake of <10% of energy in solid food has no different effects on postprandial triglyceride and uric acid compared with sucrose although fasting triglyceride was increased in people with IFG/IGT after 1 month of fructose muffins suggesting the need for caution.
Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products
Authors: Kaur Ramanpreet , Sharma Pooja , Gupta Girish K. , Ntie-Kang Fidele , Kumar Dinesh
Published: January 2020

Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason for death in South Africa, for example. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity showing more potent anti-HIV activity along with their structures, SARs & important key findings.
The Articulation of Public Problems within a Communicative Figuration Approach
Authors: Ciocea Mălina , Cârlan Alexandru , Cheregi Bianca
Published: January 2020

This article proposes an analytical shift in the theorization of public problems, from the standard (institutional) constructionist view which has informed the tradition of conceptualising social problems since Spector and Kitsuse’s classic work, to a communicative constructionist view, stemming from the mediatization paradigm. The rationale behind this shift is based on the conceptualization of the relation between various types of actors as claim makers and the logic of visibility governing processes of publicization in a media ecology marked by accelerated development. If, in the new communicational landscape, claim-making activities can turn any new-media user into a potential constructor of public problems, then we need to explain how developments in media technology reconfigure the practices of claim-making. In our understanding, such reconfigurations are just a particular case of the socio-cultural processes of transformation which are the focus of the mediatization paradigm.

On the other hand, in a Foucaultian tradition, a shift from problems to problematizations is required in order to account for the processual dynamic through which certain phenomena are analysed under specific circumstances and at certain times, while others are ignored. This shift leads to an understanding of communicative figurations as a meta-theoretical framework for the construction of public problems, accounting for the interdependencies between articulations of public problems and the dynamics of the public sphere.

With this aim in view, we first identity and evaluate the theoretical directions that are symptomatic for the transition from social problems to public ones and from problems to problematizations. In the second part, we present the heuristic potential of the concept of communicative figurations for our topic and articulate some methodological implications for a research agenda.
Depiction of Childlessness in Lithuanian Mass Media from 2011–2016: A Catalyst of Modernization
Authors: Rapoliene Grazina , Sumskaite Lina
Published: January 2020

Demographic research shows the increase of childlessness rates among women born in 1970 in comparison to those born in 1953 in Lithuania, but cultural aspects influencing reproductive behavior are under-explored. To our knowledge, the representation of childlessness in the Lithuanian mass media has not been studied yet. The aim of this article is to analyze how childlessness is depicted in the most popular mass media from 2011-2016. Our research revealed that the discourse of childlessness is undeveloped, and the depiction of voluntary childlessness is dominating. It is portrayed favorably as a modern behavior, space for which consolidation is created challenging traditional social norms. Thus Lithuanian media appear as a part of global media that promotes imitative trends of social change.
Первые данные о двустворчатых миксоспоридиях кефалевых рыб залива Нячанг (Вьетнам)
Authors: Юрахно В. М. , Ha Vo Thi
Published: January 2020

Кефалевые рыбы являются объектом промысла во Вьетнаме; некоторых из них разводят на рисовых чеках. Интенсивное развитие в этой стране марикультуры рыб, а также большая доля гидробионтов в рационе населения требуют знаний не только о видовом составе паразитов, но и об их жизненных циклах, патогенности, медицинском и эпизоотологическом значении. Фауна морских миксоспоридий в этом районе изучена крайне слабо. В пресноводных видах Вьетнама известно 36 видов и 10 не идентифицированных до вида миксоспоридий; в морских рыбах найдено 7 видов и 9 не определённых до вида Myxosporea. В марте — апреле 2018 г. в заливе Нячанг (Вьетнам, Восточное море) на предмет обнаружения миксоспоридий методом неполного паразитологического вскрытия исследовали 71 экз. рыб 7 видов из сем. Mugilidae (4 экз. Chelon planiceps, 25 экз. Valamugil speigleri, 10 экз. V. formosae, 1 экз. Planiliza subviridis, 19 экз. Paramugil parmatus, 9 экз. Mugil cephalus, 3 экз. Moolgarda seheli). Все органы просматривали под бинокуляром Olympus SZ61 при увеличении от ×15 до ×25. Мазки из тканей различных органов рыб исследовали на микроскопе Olympus CKX53 с фазовым контрастом при увеличении ×400 и на микроскопе Olympus CX41 с цифровой камерой Olympus SC50 и фазовым контрастом при увеличении ×800. Миксоспоридий фиксировали в глицерин-желатине по общепринятой методике. Промеры паразитов базировались на 20 спорах Myxobolus spinacurvatura, 25 спорах Sphaerospora dicentrarchi и 10 спорах Henneguya sp. Все промеры выполнены по стандартной методике. Для оценки численности паразитов использованы показатели экстенсивности и интенсивности инвазии. Получены первые сведения о миксоспоридиях отр. Bivalvulida кефалевых рыб залива Нячанг: найдены Myxobolus spinacurvatura в жёлчном пузыре и кишечнике у 78 % лобана M. cephalus при интенсивности инвазии, составляющей единичные споры в мазке из жёлчного пузыря и 5–11 цист в кишечнике; Sphaerospora dicentrarchi в жёлчном пузыре у 5 % черноплавничных хелонов Paramugil parmatus, 12 % Valamugil speigleri, 20 % V. formosae и 56 % Mugil cephalus при интенсивности инвазии, составляющей единичные споры в мазке; Henneguya sp. в жёлчном пузыре 8 % V. speigleri и 10 % V. formosae при интенсивности инвазии, составляющей единицы, десятки спор в мазке. Сделаны описания обнаруженных видов. Указано их распространение в других регионах Мирового океана. S. dicentrarchi — новый вид в фауне Восточного моря и Вьетнама. Он был найден не только в известном для него в других регионах M. cephalus, но и в новых хозяевах — P. parmatus, V. speigleri и V. formosae. Myxobolus spinacurvatura впервые констатирован в заливе Нячанг. Myxobolus spinacurvatura и Sphaerospora dicentrarchi известны от лобана в бассейне не только Тихого, но и Атлантического океана, поэтому предполагается, с учётом связи этих водоёмов в глубокой древности, наличие у каждого из данных паразитов в прошлом единого большого ареала, который затем был разорван вследствие мощных геологических преобразований нашей планеты.
Atlanta Field: Producing Heavy and Viscous Oil in Ultradeepwater
Authors: Marsili Marcelo D. , Rocha Paulo S. , de Almeida Ferreira Igor
Published: January 2020

Atlanta Field is a post-salt heavy-oil field located 185 km off the city of Rio de Janeiro, in Santos Basin, Brazil, at a water depth of approximately 1550 m. Atlanta, however, is not just another ultradeepwater heavy-oil field. Several additional challenges had to be overcome for its development, such as low reservoir overburden (800m), highly unconsolidated sandstone reservoir (36% porosity and 5,000 md permeability), heavy and viscous crude flow assurance (14 °API and 228 cp at initial reservoir conditions), high-naphthenic-acidity oil [total acid number (TAN) 10mg KOH/g], high-power artificial-lift pumping-systemrequirement (1,600 hp), and complex-topside crude facilities.

The development of Atlanta Field was phased in two stages: an early production system (EPS), which is expected to last from four to five years and comprises three horizontal production wells; and a definitive production system (DPS), which will add nine wells to complete the development plan with 12 horizontal producers. The first two EPS wells were successfully constructed and tested during 2013 and 2014, proving the feasibility of surpassing the great challenges imposed by the field’s unique environment and enabling the beginning of the production phase of the field. The first oil occurred in May 2018 with these two wells producing to the floating production, storage, and offloading unit (FPSO) Petrojarl I. The third and last producer of the EPS was constructed in 2019 and began operation in June of the same year. More than five million barrels of oil were already produced to date.

Marsili et al. (2015) described in detail the exploration and development phases of Atlanta Field, focusing on their challenges, the overcoming process, and solutions adopted. This current work intends to present an updated review of the paper, providing the most recent information related to the project with a subsequent focus on the production phase findings and results. Among others, the initial prediction and expectations will be compared with actual field performance. For all milestones achieved, the Atlanta project is considered a great success so far and a benchmark for the industry in this harsh and adverse environment.
Thailand Medical Mobile Application for Patients Triage Base on Criteria Based Dispatch Protocol
Authors: Sutham Krongkarn , Khuwuthyakorn Pattaraporn , Thinnukool Orawit
Published: January 2020

Background : Before admitting patients into the emergency department, the pre-hospital process is important both in terms of treatment performance and requesting resources from an emergency unit. The existing system to triage patients in Thailand is not functioning optimally in either the primary medical system or pre-hospital treatment. Areas that contain shortcomings include speed, features, and appropriate systems. There is a high possibility of misrepresenting false Initial Dispatch Code (IDC) which causes over or under utilizing emergency resources, such as rescue teams, community hospitals and emergency medical volunteers. Methods : In the application development, usability system design has been applied together with system reliability test, to optimize the pre-hospital processes specifically to sort patients by using IDC improving request for emergency resources. The development of a triage mobile application has been conducted on both iOS and Android operating systems to support patient triage based on the Criteria Based Dispatch (CBD). The 25 main symptom categories covered by CBD were used to design and develop the application, and 12 emergency medical staff including doctors and nurses were subjected to test the system in the following aspects: triage protocol correction, triage reliability, usability and user satisfaction. Results : The application development result shows the comparison between the proposed triage application and staff experience. The triage reliability test implies that the time used to triage by experienced staff, in non-trauma cases, is slower than using the application. For the usability test, the result shows that the application functions are more effective in the emergency operations and correction of IDC code representation. Conclusions : The triage application will be utilized to support the pre-hospital process and to classify patient conditions before admitting patients to the Emergency Department (ED). The application is suitable for users who are not medical emergency staff. Patients with non-trauma symptoms may be a suitable group to use the application in terms of time used to identify IDC for their own symptoms. In terms of application use, it can provide benefits to those who want to self-identify their symptoms before requesting medical services.
Increased soil moisture aggravated the competitive effects of the invasive tree Rhus typhina on the native tree Cotinus coggygria
Authors: Guo Xiao , Xu Zhen-Wei , Li Ming-Yan , Ren Xiao-Huang , Liu Jian , Guo Weihua
Published: January 2020

Background: Invasive exotic species cause significant problems, and the effects of extreme precipitation and drought, which might occur more frequently under the global climate change scenarios, on interspecific relationship between invasive and native species remain unclear. Results: We conducted a greenhouse experiment with three soil water levels (30%–40%, 50%–60%, and 70%–80% of field capacity) and two cultivation treatments (monoculture pots, one seedling of either species and mixture pots, one seedling of each species) to investigate soil water content effects on the relationship between invasive Rhus typhina and native Cotinus coggygria . Rhus typhina had lower height but bigger crown area than C. coggygria in the monoculture treatment. Rhus typhina had higher height, bigger crown area and total biomass than C. coggygria in the mixture treatment. Drought decreased the growth parameters, total chlorophyll concentration, and leaf biomass, but did not change gas exchange and other biomass parameters in R. typhina . The growth parameters, leaf area index, biomass parameters, total chlorophyll concentration, and net photosynthetic rate of C. coggygria decreased under drought conditions. The log response ratio (lnRR), calculated as ln (total biomass of a target plant grown in monoculture / total biomass of a target plant grown in mixed culture), of R. typhina was lower than that of C. coggygria . The lnRR of R. typhina and C. coggygria decreased and increased with increase in soil water content, respectively. Conclusions: Rhus typhina has greater capacity to relatively stable growth in the drought condition than C. coggygria and has strong competition advantages in the mixture with C. coggygria , especially in the drought condition. Our study will help understand the causes of invasiveness and wide distribution of R. typhina under various moisture conditions and predict its expansion under climate change scenarios.
The Effect of Sleeping Position on Heart Rate Variability in Newborns
Authors: Fister Petja , Nolimal Manca , Lenasi Helena , Klemenc Matjaž
Published: January 2020

Background : Lower heart rate variability (HRV) in a newborn might represent a risk factor for unfavourable outcome, a longer recovery after illness, and a sudden infant death. Our aim was to determine whether the newborn’s sleeping position is associated with HRV. Methods : We performed a prospective clinical study in 46 hospitalized cardiorespiratory stable term newborns. During sleeping, we measured the parameters of HRV in four body positions (supine, supine with tilt, prone, prone with tilt). Results : The TP (total power spectral density) was significantly higher when lying supine in comparison to prone (p = 0,048) and to prone with tilt (p = 0,046). The HF (high frequency of power spectral density) in the supine position without tilt tended to be higher compared to prone without tilt (p > 0,05). The LF (low frequency power) was significantly higher when lying supine compared to prone, both without tilt (p = 0,018). TP and HF showed a positive correlation with gestational age (p = 0.044 and p = 0.036, respectively). Conclusions : In term newborns, sleeping position is associated with HRV. Higher TP and HF were found in the supine position, which might reflect better ANS stability. Gestational age positively correlated with TP and HF power, but only in supine position.
Seasonal variation and change trends for quit smoking: evidence from Internet search engine query data
Authors: Hu Dingtao , Lou Xiaoqi , Meng Nana , Xie Qiaomei , Zhang Man , Zou Yanfeng , Wang Fang
Published: January 2020

Background: The outcomes of smoking have generated considerable clinical interest in recent years. Although people from different countries are more interested in the topic of quit smoking during the winter, few studies have tested this hypothesis. The current study aimed to quantify public interest in quitting smoking via Google.Methods: We use Google Trends to obtain the Internet search query volume for terms relating to quit smoking in major northern and southern hemisphere countries in this research. Normally search volumes for the term “quit smoking + stop smoking + smoking-cessation” were retrieved within the USA, the UK, Canada, Ireland, New Zealand and Australia from January 2004 to December 2018. Seasonal effects were investigated using cosinor analysis and seasonal decomposition of time series models.Results: Significant seasonal variation patterns in those search terms were revealed by cosinor analysis and demonstrated by the evidence from Google Trends analysis in the representative countries including the USA (pcos = 2.36×10-7), the UK (pcos < 2.00×10-16), Canada (pcos < 2.00×10-16), Ireland (pcos <2.00×10-16) ,Australia (pcos = 5.13×10-6) and New Zealand (pcos = 4.87×10-7). Time series plots emphasized the consistency of seasonal trends with peaks in winter / late autumn by repeating in nearly all years. The overall trend of search volumes for quitting smoking, observed by dynamic series analysis, has declined from 2004 to 2018.Conclusions: The preliminary evidence from Google Trends search tool showed a significant seasonal variation and a decreasing trend for the RSV of quit smoking. Our novel findings in smoking-cessation epidemiology need to be verified with further studies, and the mechanisms underlying these findings must be clarified.
Azithromycin exposure induces transient microbial composition shifts and decreases the airway microbiota resilience from PM2.5 stress in healthy adults: a randomized, double-blind, placebo-controlled trail.
Authors: Du Sisi , Zou Xiaohui , Deng Xiaoyan , Shang Lianhan , Sun Aihua , Mu Shengrui , Zhao Jiankang , Wang Yimin , Feng Xiaoxuan , Li Binbin , Wang Chunlei , Liu Shuai , Lu Binghuai , Liu Yingmei , Zhang Rongrong , Tong Yigang , Wang Chen , Cao Bin
Published: January 2020

Background Azithromycin, widely used in recent years, can change the airway microbiota in patients with chronic lung diseases. Little data exists regarding the effects of azithromycin administration on airway microbiota among healthy adults. Therefore, we conducted a randomized, double-blind, placebo-controlled trial to assess the process of variation and re-establishment of the airway microbiota after azithromycin exposure in healthy adults. Methods Forty-eight healthy volunteers were enrolled and randomly assigned into two groups. 500mg azithromycin or placebo was administered once daily for 3 days. We collected the induced sputum at the day before the drugs administration (D0), the day after the treatment course was completed (D4), 14 days, 30 days and 60 days post-dosing. 16S rRNA gene sequencing and quantification were applied to the induced sputum samples. We collected the environmental information including air quality data [particulate matter (PM 2.5 ) and PM 10 , air quality index (AQI) values] that might have an influence on the airway microbiota during the study. The subjects’ respiratory tract infection (RTI) events during sampling were recorded. Results Azithromycin didn’t alter bacterial load but significantly reduced species richness and Shannon index. Azithromycin exposure resulted in decrease in the detection rate and relative abundance of different families belonging to Veillonellaceae , Pasteurellaceae , Leptotrichiaceae , Neisseriaceae and Fusobacteriaceae . By contrast, the relative abundance of taxa belonging to Streptococcus increased immediately after azithromycin intervention. The shifts in the microbial community composition require about 14 days to recover while alpha-diversity recovered later. The high concentration of PM 2.5 contributed to a novel variability in microbial community composition of azithromycin group at D30 (30 days after baseline). The network analysis found that azithromycin altered the microbial interactions within airway microbiota. The influence was still obvious at D14 when the relative abundance of most taxa had returned to the baseline level. Conclusions Azithromycin has transient effect in airway microbiota of healthy adults and decreases the ability of the airway microbiota resilient from PM 2.5 stress. The influence of azithromycin on microbial interactions is noteworthy though the airway microbiota has returned to the near-baseline level.
Capturing complex vaccine-immune-disease relationships for free-ranging koalas: IL17 production is an important intermediate factor against chlamydial disease
Authors: Lizárraga David , Timms Peter , Quigley Bonnie L , Hanger Jon , Carver Scott
Published: January 2020

The authors have withdrawn this preprint from Research Square
Client satisfaction and Competency of Healthcare Providers with the services of BRAC Maternity Centres – A Cross Sectional Study
Authors: Khan Nusrat , Jolly Saira Parveen , Chowdhury Tridib Roy , Alam Ariful , Rahman Mahfuzar , Afsana Kaosar
Published: January 2020

Background Client satisfaction and competency of the healthcare providers are key areas to ensure good health service delivery anywhere. The objective of this study was to understand the competency of the healthcare providers of BRAC maternity centres (BMC) in rural areas of Bangladesh and acceptance of their services at client level. Methods It was a cross-sectional exploratory mixed method study. For exploring client satisfaction and expected services of the clients, 2810 married women, aged 15-44 years with a delivery outcome within one year of interview, were included in the survey. In addition, 12 observations, and19 in-depth interviews of patients and their attendants were used for collecting information on competency of the midwives and Community Skilled Birth Attendants (CSBAs) from four upazillas in Bangladesh. The BMC in Mithapukur was functioning for two years preceding the survey, whilst rest of the three were established before two months of the survey. For this reason client satisfaction information was collected only from BMC in MIthapukur. On the other hand, information on competency of midwives and CSBAs were collect from all BMCs. Results Mean age of the respondents was around 24 years and more than 96% were housewives. All facilities were well equipped to provide maternity services. We found that more than 92%, 91% and 87.5% of the beneficiaries of BMC in Mithapukur were satisfied with the antenatal care (ANC) check-up, normal delivery and episiotomy services. For all other centres, most of the clients expected caesarean section facilities, availability of doctors and financial support from the centres. In terms of competency, the midwives and CSBAs were satisfactorily competent to provide all required services. Conclusion Overall, the results suggest the BMC holds competent workforce and similar service delivery strategies can be replicated in poor resource settings and BMCs to ensure quality care and trust in the patients for healthcare service utilisation. Keywords: Antenatal care, delivery care, postnatal care, neonatal care, competency, midwife, community skilled birth attendant, client satisfaction
Feasibility of in vivo Magnetic Induction Tomography in Rabbits
Authors: Chen Qihui , Liu Runsheng , Wang Cong , Liu Ruigang
Published: January 2020

Background: As a non-contact, non-invasive medical imaging technique, magnetic induction tomography (MIT) can measure the conductivity distribution inside the human body. Numerical calculation and physical phantom tests have showed the accuracy of MIT in principle. However, very few human studies have limited the development and application. At the key stage before clinical trials, animal experiment will be an effective method to verify the feasibility of in vivo detection the conductivity variation inside of biological body. Methods: An abdominal subcutaneous injection rabbit model was used to simulate the local conductivity perturbation by injecting a 0.9% NaCl solution along with in vitro heparinized blood step by step. An insulated and sliding operation console was built to carry out the animal tests. An improved 16-channel MIT data acquisition system was used to record the data at 13.56 MHz and 4 seconds per frame. A series of time-difference reconstructed images, relative to non-injection, were obtained by the regularized Newton-Raphson algorithm for every 3 mL of injection. Results: 15 rabbits were divided by two groups. Six rabbits were injected with 0.9% NaCl solution and nine rabbits were injected with the in vitro heparinized blood. The target with an increased conductivity distribution can clearly be observed in all the reconstructed images. The maximum target value in each image increased with the injection dosage. The slopes of the regressive line for the mean of maximum target value in two groups were statistically different. Conclusion: Local conductivity perturbation inside of the rabbits is able to be reconstructed. The position and conductivity difference relative to the surrounding tissue of the target can be reflected correctly. This preliminary rabbit test shows the feasibility of the in vivo application for MIT and will be the basis for further animal tests and clinical trials in the future.
LINGUISTIC PROFICIENCY DEVELOPMENT THROUGH SCAFFOLDING: A SPANISH TEACHER’S BELIEFS AND PRACTICES IN AUSTRALIA
Authors: Devina Devina , Varona-Domblas Santiago
Published: January 2020

In determining the implementation and execution of the classroom activities, the teacher’s beliefs plays an important role as one of the fundamental aspects of language teaching. In-depth, the beliefs also influence the learner’s competency and the achievement of learning outcomes. This research aims at observing the beliefs of a Spanish language teacher in a private language school in Australia. Data were gathered through interview and classroom observations. The interview was designed to explore the teacher’s beliefs regarding the language learning approach. Furthermore, the classroom observations were conducted through 1) complete observer observation and 2) complete participants observation. They were carried out to see to what extent the teacher implemented the beliefs into action. Pre-classroom questionnaires on the learner’s background were distributed to know the learners’ background. In the era where communicative approach becomes the axis of language teaching, this study suggests “scaffolding” as an alternative approach to language teaching. The finding indicates that some primary factors affecting the teacher to hold his beliefs are: limited classroom duration, small class size, and the condition of Spanish as a foreign language (FL) in Australia – where learning resources are limited. In the learning condition where the target language (TL) resources found to be scarce, this ‘scaffolding’ approach successfully and effectively equips learners with adequate knowledge of Spanish. Taking the ‘scaffolding’ as the major foundation to develop learners’ linguistic proficiency, this research provides insight regarding the use of ‘scaffolding’ toward language teaching and learning.
Site Suitability Analysis for Water Conservation Using AHP and GIS Techniques: A Case Study of Upper Sina River Catchment, Ahmednagar (India)
Authors: Badhe Yogesh , Medhe Ravindra , Shelar Tushar
Published: January 2020

The site suitability for construction of water conservation structures is an important step towards groundwater conservation in arid and semi-arid regions. Water is the most crucial for maintaining an environment and ecosystem which is helpful to sustaining all forms of the life. The increasing water scarcity day to day has been one of the common problems over a period of time. On top of it, when the area is a part of rain shadow zone like Ahmednagar district, water conservation activities are become more important. The present study aims to identify the suitable zones for water conservation activity. Multi- criteria evaluation is carried out using Geographic Information System (GIS) techniques to help the choice makers in defining suitable site for construction of water conservation structures. Different layers which were considered for multi-criteria evaluation: slope, land use land cover, soil texture, lithology, soil depth, soil erosion, wells, lineaments and drainage network. Analytical Hierarchy Processes (AHP) is used for weighted sum to find suitable sites for implementation of water conservation activity using selected criterions. The site suitability map was classified into four classes: highly suitable, moderately suitable, less suitable and not suitable with area of 19.19%, 26%, 49.03% and 5.78, respectively. This map will help for selection of suitable sites for construction of Mati Nala Bund (MNB), Check Dam, Cement Nala Bund (CNB) and Continuous Contour Trenches (CCT) for conservation of groundwater resource in the region.