bluuebunny/crossref_metadata_2025 huggingface dataset:
The Sensitive Regions of Surface Air Temperature and Terrestrial Precipitation to Global Warming, IPO and AMO
Authors: Xu Chengyu , Tao Li
Published: March 2023

Against the background of global warming (GW), the distribution of decadal (10–20-year), multidecadal (20–50-year) and secular (>50-year) variabilities and their causes of surface air temperature (SAT) and terrestrial precipitation were explored. We applied the singular spectrum analysis method to categorize the low-frequency variabilities of global SAT and terrestrial precipitation anomalies. Three sea surface temperature (SST) modes were identified through singular value decomposition that affect the low-frequency variabilities of global SAT and terrestrial precipitation anomalies—namely, the GW, Interdecadal Pacific Oscillation (IPO) and Atlantic Multidecadal Oscillation (AMO) modes. The sensitive regions of SAT and terrestrial precipitation to GW, IPO and AMO were validated through an information flow method. Significant decadal and multidecadal variabilities of SAT were found to exist over the Pacific and Northern Atlantic, respectively, because of the IPO and AMO. In terms of terrestrial precipitation, a large area with a wet trend was found over Eurasia at mid-to-high latitudes, and this trend was especially remarkable in the boreal winter half-year (November–April), as compared with that in the boreal summer half-year (May–October). As a result, it could be concluded that GW is the trigger of the wet trend. By employing artificial neutral networks with a self-organized map to cluster the key patterns of vertically integrated water vapor flux, we found that the synopitic circulation related to the wet trend is characterized by westerly flow that transports water vapor from the northeastern Atlantic to Eurasia, which is favorable for precipitation there both in the boreal winter and summer half-year.
Node MCU based Pocket Cloud Memory System for Secure Data Storage
Authors: Manjula S. , Sudha M. Swarna , Kumar D. Mohan
Published: March 2023

Many people nowadays rely on storage devices such as external hard drives and pen drives to store files. The users reported that their drives kept disconnecting and causing problems in some operating systems. Some models have their own set of problems. If the user has important data that has been compromised by infected files, viruses, or malware, the user will undoubtedly require adequate protection. These drives require protection against file loss, malware, and hardware failure. In this work, an innovative wireless handheld storage device called Pocket Cloud has been proposed, which includes data query processing, and IoT sensor data processing. When connected to a power supply, it can be used as a wired storage device. Users can also transfer files between cloud services. Volumes can also be attached, detached, swapped, and edited. The pocket cloud provides remote file access, additional cloud storage, and convenient web backup options. For added security, the user can encrypt data with a key before uploading it to the device.
Delay tumor progression with the introduction of engineered impactive cells
Authors: Hong Dengli , Li Shuiping , Ma Junxia , Mu Lili , Wu Wanying , Hu Ye , Wang Yiding , Guo Xiaolin , Cai Jiejing , Wang Xi , Wei Jieping , Liu Yanjun , Xie Hongyu
Published: March 2023

The complete eradication of tumor cells is extremely challenging. An alternative strategy is tumor containment, which utilizes the interaction of tumor cells and has achieved promising results. However, effective interaction and controllability are not guaranteed for a given tumor. Here, we proposed a novel strategy comprising an impactive cell population and a control system and realized it in leukemic mouse model. To identify impactive cells, we xenografted six leukemic cell lines together. We found NALM-6 cells strongly impact the infiltration of other leukemic cells. To control NALM-6 cells, we introduced the herpes simplex virus thymidine kinase/ganciclovir suicide system. We found they effectively controlled the infiltration of NALM-6 cells. To evaluate the effectiveness, we used this strategy in mice xenografted with REH cells. The survival time was significantly elongated. In summary, our strategy guaranteed the impact and controllability of effector cells, thereby extending the tumor containment strategy.
Analysis of fecal microbiome and metabolome changes in goats with pregnant toxemia
Authors: Jin Bingyan , Wang Ruoqian , Hu Jiada , Wang Yan , Cheng Panpan , Zhang Jiancong , Zhang Jiahui , Xue Gang , Zhu Yan , Zhang Yunhai , Fang Fugui , Liu Ya , Li Yunsheng
Published: March 2023

Background Pregnancy toxemia is a common disease, which occurs in older ewes that are pregnant with multiple lambs in the third trimester. Most of the sick goats die within a few days, which can seriously impact the economic benefits of goat breeding enterprises. The disease is believed to be caused by malnutrition, stress, and other factors, that lead to the disorder of lipid metabolism, resulting in increased ketone content, ketosis, ketonuria, and neurological symptoms. However, the changes in gut microbes and their metabolism in this disease are still unclear. The objective of this experiment was to evaluate the effect of toxemia of pregnancy on the fecal microbiome and metabolomics of ewes.
ResultsEight pregnant ewes suspected of having toxemia of pregnancy (PT group) and eight healthy ewes during the same pregnancy (NC group) were selected. Clinical symptoms and pathological changes at necropsy were observed, and liver tissue samples were collected for pathological sections. Jugular venous blood was collected before morning feeding to detect biochemical indexes, and fecal samples were collected simultaneously using 16SrRNA and Liquid Chromatography-Mass Spectrometry (LC-MS) techniques to detect different flora and metabolites. Autopsy revealed that the liver of the pregnancy toxemia goat was enlarged and earthy yellow, and the biochemical results showed that the serum levels of aspartate aminotransferase (AST) and β-hydroxybutyric acid (B-HB) in the PT group were significantly increased, while calcium (Ca) levels were significantly reduced. Sections showed extensive vacuoles in liver tissue sections. The microbiome analysis found that the richness and diversity of the PT microbiota were significantly reduced.Metabolomic analysis showed that 125 differential metabolites were screened in positive ion mode and enriched in 12 metabolic pathways. In negative ion mode, 100 differential metabolites were screened and enriched in 7 metabolic pathways.
ConclusionsEvidence has shown that the occurrence of pregnancy toxemia is related to gut microbiota, and further studies are needed to investigate its pathogenesis and provide research basis for future preventive measures of this disease.
Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia
Authors: Akiyama Hiroki , Zhao Ran , Ostermann Lauren , Li Ziyi , Baran Natalia , Yazdani Samar , Ayoub Edward , Pryor Malcolm , Nishida Yuki , Mak Po , Ruvolo Vivian , Carter Bing , Andreeff Michael , Ishizawa Jo
Published: March 2023

Resistance to apoptosis in acute myeloid leukemia (AML) cells causes refractory or relapsed disease, associated with dismal clinical outcomes. Ferroptosis, a mode of non-apoptotic cell death triggered by iron-dependent lipid peroxidation, has been investigated as potential therapeutic modality against therapy-resistant cancers, but our knowledge of its role in AML is limited. We investigated ferroptosis in AML cells and identified its mitochondrial regulation as a therapeutic vulnerability. GPX4 inhibition induces ferroptosis in AML cells, accompanied with characteristic mitochondrial lipid peroxidation, exerting anti-AML effects in vitro and in vivo. Electron transport chains (ETC) are primary sources of coenzyme Q10 (CoQ) recycling for its function of anti–lipid peroxidation in mitochondria. We found that the mitochondria-specific CoQ potently inhibited GPX4 inhibition–mediated ferroptosis, suggesting that mitochondrial lipid redox regulates ferroptosis in AML cells. Consistently, Rho0 cells, which lack functional ETC, were more sensitive to GPX4 inhibition–mediated mitochondrial lipid peroxidation and ferroptosis than control cells. Furthermore, degradation of ETC through hyperactivation of a mitochondrial protease, caseinolytic protease P (ClpP), synergistically enhanced the anti-AML effects of GPX4 inhibition. Collectively, our findings indicate that in AML cells, GPX4 inhibition induces ferroptosis, which is regulated by mitochondrial lipid redox and ETC.
Are TIPs involved in the stomatal regulation in sunflower under different conditions?
Authors: Abdelhakam Selwan , Rabei Sami H. , Nada Reham M. , Abogadallah Gaber M.
Published: March 2023

In this study we aimed at elaborating the contribution of sunflower stomata on both sides in the stomatal conductance (gs) and the relation between its regulation and specific aquaporins expression under different conditions. Our results indicated higher stomatal index of the adaxial than the abaxial as well as the photosynthesis (A), manifesting that stomatal index was a key factor for A and/or stomatal conductance (gs). Sunflower plants could absorb CO2 from both leaf surfaces and therefore have a more efficient photosynthetic CO2 uptake and fixation rates than other C3 species maintaining the high concentration of intercellular CO2. We also indicated that stomatal regulation rather than stomata per se determines the rate of transpiration (E). Key regulators of stomata are plant vacuoles in which aquaporins (TIPS) function. Insilico characterization of sunflower TIPS deduced from database indicated a conserved motif MIP with other species proved to transport water and involved in many different physiological processes. Inconsistent regulation of TIPs under different conditions was detected indicating TIPs were not involved in stomatal regulation at these conditions. Hierarchical analysis showed that TIP7 was distantly related to the other sunflower identified aquaporins.
WITHDRAWN: Enhancing Cloud Storage Security with Multi-Authority Privacy Preserving Data Signcryption using Rijndael Encryption and HMAC
Authors: A Abirami , S Bhuvaneswari , K Chandraprakash Reddy , M Eshwanth G , S Imran Khan
Published: March 2023

In recent times, data storage security in cloud storage systems has become a major concern due to the rising incidents of security breaches and data theft by attackers or hackers. To address this challenge, researchers have focused on developing efficient fine-grained access mechanisms in cloud storage space. Attribute Based Encryption (ABE) and Attribute Based Signature (ABS) have emerged as promising techniques for providing confidentiality and authenticity, respectively, to different types of data. These techniques are combined to form Attribute Based Signcryption (ABSC). However, most existing solutions are impractical for real-world scenarios due to the involvement of multiple third-party services and high computation and communication overhead. Therefore, we propose a novel ABSC technique that provides privacy protection and public verifiability for the signcryptor and ciphertext, respectively. Our approach aims to enhance the security of cloud storage systems by addressing the limitations of existing solutions.
Investigating rainfall-runoff and turbidly behavior during the rainy season in west of Japan
Authors: Sawaf Mohamad Basel Al , Kawanisi Kiyosi , Bahreinimotlagh Masoud
Published: March 2023

Understanding the recent variability in massive rainfall patterns is essential to provide a clear image about underlying hydrological processes that occur over a watershed scale. The main objective of this study is to investigate the variability of rainfall events in Western Japan as a result of climate change and examine the related runoff-turbidity dynamics during rainy season. To fulfill the research objectives, we investigated the changeability of the precipitation records in the Gōno River watershed for the last two decades and the related runoff-turbidity behavior during floods using the turbidity-discharge (T-Q) loops and quantified using an improved hysteresis index. The findings revealed a kind of intense rainfall periodicity of 3 ~ 4 years. In addition, spatial pentads analysis exhibited various intensities of accumulated precipitation suggesting that there is no specific spatial zone of extreme rainfall. Regarding the turbidity-discharge behavior, it was found that clockwise hysteresis patterns were induced by sediment sources from near channel areas, alternatively, anticlockwise pattens were produced due to soil erodibility from the nearby areas. Another interesting finding was a notable behavior of turbidity during floods such as “bursts” or “local peaks” may represent an earlier (or later) arrival of turbid waters from nearby distant sources at an upstream section as a result of an intense precipitation. One of the fundamental challenges in the quantification of hysteresis patterns is that there is no accepted definition on how to determine the start and the end of a flood event which may led to a bias in the quantification of these patterns.
Assessing the Readiness of Staff at Uitm Pahang Toward Big Data Adoption
Authors: Ujang Suriyati , Saad Zuria Akmal , Mohamad Mastura , Abdullah Mohd Amli , Sarimin Siti Norbaini
Published: March 2023

The adoption of Big Data (BD) in higher education is still in its initial stages compared to other sectors. This has led to numerous frameworks for BD adoption in higher education, as different studies cover different scopes and objectives. This study aims to explore the readiness of University Teknologi MARA Cawangan Pahang (UiTM Pahang) towards BD adoption. Diffusion of Innovation and Technology, Environment, and Organization Theories will be used to explore the organization's readiness, while Unified Theory and Use of Technology elements will explore individual acceptance of BD. According to the findings, 25.7% of respondents are aware of the term "big data" but lack the skills to apply it in their workplace, and the majority (80%) of UiTM Pahang staff agree that adopting big data will increase their productivity. In the context of the use of technology, 70% of the respondents agreed that UiTM Pahang would support the use of big data in the organization. Approximately 80% of respondents believe that using big data will assist UiTM Pahang improve student performance, the teaching process, decision-making, and knowledge of future trends, thereby assisting in changing the academic curriculum. Hence, to increase the awareness and readiness of the staff toward BD adoption at UiTM Pahang, the top management can impart BD training and motivational support. The positive outlook of the overall state would lead to the ongoing improvement of the education system with continuous aid from both management and staff.
Pulp regeneration by transplantation of dental pulp with the synergy of concentrate growth factor: An in vitro and in vivo study
Authors: Xie Yuhong , Feng Xingrong , Hu Yuntong , Wang Zhi , Xia Xueling , Luo Xinxiao , Xiao Yuhong
Published: March 2023

Objectives This study aimed to investigate the mechanism of successful autologous pulp transplantation through semi-in situpulp regeneration in animal experiments and three case reports of autologous pulp transplantation protocols using concentrated growth factor (CGF)-enriched pulp. Material and methods Wisdom tooth pulp was removed, placed in the anterior molar canal, and implanted in the subcranial space of the cranial apex of SD rats to establish an animal model of hemi-in situpulp regeneration. Postoperative histological observations were performed. Three patients diagnosed with chronic periapical inflammation in a single canal of the anterior teeth and satisfied with the presence of wisdom teeth were recruited, and the CGF-rich autologous pulp transplantation protocol was selected after obtaining informed consent. Result Animal experiments showed no detachment of all SD rat grafts after surgery, a large amount of neovascularization by HE staining, and positive vascular expression by immunohistochemistry for both human CD31 and murine CD31. The three patients were followed at 3 and 6 months after surgery, and all teeth showed improvement in periapical lesions and positive pulp electrical vitality tests. Conclusion The results of animal experiments indicate that isolated pulp can survive and establish a blood supply with the host, and the addition of CGF facilitates regenerative pulp formation. The clinical results also demonstrated that CGF-rich autologous pulp transplantation protocols are a good regenerative pulp therapy (RET) for the treatment of chronic apical periodontitis in anterior teeth.
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state
Authors: Kim Carla , Li Jingyun , Dang Susanna , Schurmann Paul , Dost Antonella , Moye Aaron , Paschini Margherita , Bhetariya Preetida , Bronson Roderick , Sui Shannan Ho
Published: March 2023

Alveolar type 2 (AT2) cells, the epithelial progenitor cells of the distal lung, are known to be the prominent cell of origin for lung adenocarcinoma. The regulatory programs that control chromatin and gene expression in AT2 cells during the early stages of tumor initiation are not well understood. Here, we dissected the response of AT2 cells to Kras activation and p53 loss (KP) using combined single cell RNA and ATAC sequencing in an established tumor organoid system. Multi-omic analysis showed that KP tumor organoid cells exhibit two major cellular states: one more closely resembling AT2 cells (SPC-high) and another with loss of AT2 identity (hereafter, Hmga2-high). These cell states are characterized by unique transcription factor (TF) networks, with SPC-high states associated with TFs known to regulate AT2 cell fate during development and homeostasis, and distinct TFs associated with the Hmga2-high state. CD44 was identified as a marker of the Hmga2-high state, and was used to separate organoid cultures for functional comparison of these two cell states. Organoid assays and orthotopic transplantation studies indicated that SPC-high cells have higher tumorigenic capacity in the lung microenvironment compared to Hmga2-high cells. These findings highlight the utility of understanding chromatin regulation in the early oncogenic versions of epithelial cells, which may reveal more effective means to intervene the progression of Kras-driven lung cancer.
Prevalence of depression among elderly women in India- An intersectional analysis of the Longitudinal Ageing Study in India (LASI), 2017-2018
Authors: Panda Paramjot , Dash Prashansa , Behera Manas , Mishra Trupti
Published: March 2023

Epidemiological transition in India shows a shift in disease burden from youth to the elderly. As Life Expectancy increases, a greater burden is placed on the state, society, and families in India. Mental health disorders are insidious, debilitating Non-Communicable Diseases (NCDs) that afflict people, their families, and generations down the line. Globally, depression is the leading cause of mental health-related disability. It is estimated that mental illness contributes to 4.7% of Disability Adjusted Life Years (DALYs) in India. It is predicted that by 2026, the elderly's sex ratio will increase to 1,060 feminizing ageing. Research has shown that elderly women in developed countries like the United States are more prone to depression. Chronic morbidities are more common in women than in men, and they may suffer from poor vision, depression, impaired physical performance, and elder abuse. Mostly widowed, economically dependent, lacking proper food and clothing, fearing the future, and lacking proper care, they have difficulty coping with these health problems. There are surprisingly few studies on elderly female depression. Therefore, we want to hypothesize the prevalence of depression among women in different regions and demographic groups in India, and what factors may contribute to these differences. Using intersectional analysis with the data from Wave 1 (2017-2018) of the (Longitudinal Ageing Study in India) LASI (N = 16,737) we were able to explore the intersecting patterns between different variables and how people are positioned simultaneously and position themselves in different multiple categories based on the type of place of residence, age and level of education. Through the study we further aim to determine the prevalence of depression among elderly female in the age group of 60 in different states using the Chloropleth map. The findings of the study highlight the significance of the place of residence in the development of depression among elderly women, with the rural area being associated with a higher prevalence of depression compared to urban area. When compared to people with higher literacy, those with low literacy were significantly associated with depression. State-wise, there is a huge difference between the prevalence of elderly women depression in rural and urban areas. The study highlights the vulnerability of elderly women to depression. It is possible for the government to develop programs that address the needs of elderly women, both in urban and rural areas, to reduce depression. Multi-factor approaches to mental health, which consider age, literacy, and location, are essential. Programs targeting specific populations can be developed to address depression's root causes..
Zinc oxide nanoparticles induce renal injury by initiating oxidative stress, mitochondrial damage and apoptosis in renal tubular epithelial cells
Authors: Liu Shuang , Shi Yang , Zhou Han , Li Jingyan , Yi Simeng , Liao Bin , Cao Ji-Min , Li Guang
Published: March 2023

Zinc oxide nanoparticles (ZnO NPs) are widely used in many fields due to their unique physicochemical properties. However, the renal toxicity of ZnO NPs and the underlying mechanisms has not been well elucidated. Here we found that ZnO NPs induced injury of human renal proximal tubular epithelial cells (HK-2) in a dose- and size-dependent manner, as revealed by CCK-8, LDH and AnnexinV-FITC assay. Mechanistically, ZnO NPs promoted oxidative stress and mitochondrial damage by generating ROS, and finallyinduced apoptosis of HK-2 cells, as evidenced by upregulation of Bax and Caspase 3 and downregulation of Beclin 1. In vivo, ZnO NPs induced tubular epithelial cell apoptosis and elevations of serum creatinine, serum urea nitrogen, and urinary protein in mice suggesting damage of renal structure and function. Collectively, this study demonstrated that oral intake of ZnO NPs induced nephrotoxicity both in vitro and in vivo mainly via inducing oxidative stress, mitochondrial damage and apoptosis in the tubular epithelial cells.
Graph Convolutional Networks based Non-Negative Matrix Factorization aware Community detection
Authors: Scholar Pawan Meena Research , Professor Mahesh Pawar Associate , Professor Anjana Pandey Associate
Published: March 2023

Nonnegative matrix factorization (NMF) is widely used in community discovery because of its effectiveness and easy interpretability. However, most of the existing NMF-based community detection methods are linear. They cannot effectively deal with the nonlinear characteristics of complex networks, resulting in further improvement in community detection performance. Aiming at this problem, a convolution graph network (GCN) enhanced nonlinear NMF community discovery method NMFGCN is proposed. NMFGCN consists of two main modules: GCN and NMF, where GCN is used to learn network node representations, and NMF uses node representations as input to obtain network community representations. In addition, a joint optimization method is proposed to train NMFGCN, which enables NMFGCN to have nonlinear feature representation capabilities and enables GCN and NMF to promote each other and obtain better community segmentation results. Many experiments on artificial synthetic networks and entire networks show that NMFGCN is superior to current NMF-based community discovery methods , thus proving that NMFGCN can improve the performance of NMF community discovery methods. In addition, NMFGCN also outperforms Deep Walk and LINE standard graph representation learning methods.
College Students' Suicidal Behavior: Protective and Risk Factors in a State University in Pampanga, Philippines
Authors: Bangalan Sherna , Otanes Marie Eugenie , Escalona Arsenio
Published: March 2023

Background
The world's fourth leading cause of death among young people is a suicide, a serious public health concern. In the Philippines, there is an increasing number of suicide deaths.
Objective
The present study aims to investigate the prevalence of suicidal behavior among college students in a state university in Pampanga, Philippines, and examine the risk and protective factors most associated with suicidal behavior.
Method
A cross-sectional study used data from 522 college students obtained through an online survey; 443 were included in the final analysis. Six (6) standardized scales were used to assess the study variables. 24% of the participants have suicidal ideation, 14% have suicidal plans, and 9% would attempt to commit suicide.
Results
A multiple logistic regression analysis revealed that family support and spiritual well-being were protective factors against suicide attempts. On the contrary, depressive symptoms and adverse childhood experiences increased the likelihood of the participants committing suicide.
Discussion
Even though an association does not imply causation, suicide prevention programs and policies would benefit from understanding how family support, spiritual well-being, and suicidal behavior are interconnected. Moreover, treating depressive symptoms and adverse childhood experiences should be integrated into targeted mental health interventions to reduce suicidal behavior.
The Values of k-th Order of Entire Functions Share 1 CM with its Linear Differential Polynomial
Authors: Wei Huanhuan , Hu Wenju
Published: March 2023

In this paper, we discuss the values of k-th order of the entire functions which with its linear differential polynomial share 1 CM. We prove that if k(≥ 3) is an integer, for the given non-negative real number λ (may be infinity), then there exists an entire function ƒ(z) which with its linear differential polynomial share 1 CM, such that the k-th order of ƒ(z) is λ.
MSC Classification: 30D35 , 30D20
The feasibility of adding wood quality traits as selection criteria in the Galician Pinus pinaster Aiton breeding program: case study
Authors: TORRES-SÁNCHEZ Esteban , PRADA Eva , DÍAZ Raquel
Published: March 2023

Pinus pinaster is a very important species for the Galician wood industry. A genetic breeding program was started in the 1980s to select plus trees based on growth and straightness. In this study, we estimated genetic parameters, juvenile-mature correlations and genetic gains in basic density (BD) and the dynamic modulus of elasticity (MOEd) in Galician breeding families, as well as their relation to volume, straightness, and tree slenderness. All traits were measured at a tree age of 12 years in three half-sib progeny trials. Wood quality traits were also measured at 24 years in two other trials. All progeny trials followed a randomized complete block design and the data were analyzed using several mixed-model approaches. The individual heritability of MOEd remained stable at both ages (~ 0.39) but decreased with age for BD (from 0.44 at age 12 to 0.24 at age 24). The high juvenile-mature correlations (0.51 for BD, 0.57 for MOEd) observed support the viability of early selection for both traits at 12 years. Both wood quality traits correlated positively with each other and weakly with volume, straightness and tree slenderness. Selecting a minimum number of the best families, based on volume or any wood quality trait, would generate genetic gains for the selecting trait and prevent genetic losses of non-selecting traits. We also identified specific families showing positive genetic gains for all traits. The research indicates that either or both of these wood quality traits could be included as new selection criteria in the Galician breeding program.
Rapid genotyping of plant samples using TaqMan TM assays
Authors: Hicks Leannah K. , Fili Stavroula , Walker Elsbeth L.
Published: March 2023

Insertional mutagenesis is a routine method used in reverse genetics, but commonly-used end-point PCR molecular screening methods are flawed because they rely on negative results and require labor intensive gDNA extractions. To address this, we have developed TaqMan™ genotyping assays that allow us to compare the copy number of specific alleles of a gene of interest to an internal control. The method is effective with ‘on-the-fly’ template prep with no purification that allows for streamlined genotyping of up to 95 samples in ~ 2 hours. TaqMan™ genotyping has been effective in both identifying all possible genotypes (wild type, heterozygous, and homozygous) for insertional mutants and for determining transgene copy numbers of individual transformation events in transgenic lines. Expression of maize transposon-insertion alleles was determined and the correlation between the transposon’s insertion location and its ability to effect gene expression was examined.
Extremal parameter for double phase problem with concave-convex nonlinearity
Authors: Mishra Pawan Kumar , Silva Kaye , Tripathi Vinayak Mani
Published: March 2023

Note: Please see pdf for full abstract with equations.
In this work, we study the following problem
−Δpu − div(μ(x)|∇u|q−2∇u) = λf(x)|u|γ−2u + g(x)|u|r−2u in Ω,
u = 0 on ∂Ω,
where Ω ⊂ RN,N ≥ max{2, p} is a bounded smooth domain, 1 < γ < p < q < r < p∗ = Np/(N−p) and λ is a positive real parameter. The weights f, g : Ω → R are continuous and bounded functions, where g may change sign on Ω. The function 0 ≤ μ ∈ Cc(Ω) ∩ L∞(Ω) and μ ≢ 0. The objective of this work is to explore the optimal control on λ to apply Nehari manifold
Mathematics Subject Classification (2010). Primary 35A02; Secondary 35A15, 35B32.
Stability Analysis of a Fractional Order of a New Corona Virus Disease (Covid-19) Model
Authors: Labzai Abderrahim , Belam Mohamed , Rachik Mostafa
Published: March 2023

In this paper, we propose a fractional order SEIHR pandemic model of Covid-19 that describesthe spreadability of Corona virus within a population. We prove the global existence, positivity, and bound-edness of solutions. In addition, the local and the global stability of the disease-free equilibrium and thedisease equilibrium are studied by using Routh-Hurwitz criteria and construction an appropriate Lyapunovfunctions. Finally, numerical simulations are performed to verify the theoretical results.
The conservation status of the Cretan Endemic Arthropods under Natura 2000 network
Authors: Bolanakis Giannis , Paragkamian Savvas , Chatzaki Maria , Kotitsa Nefeli , Kardaki Liubitsa , Trichas Apostolos
Published: March 2023

Arthropods' decline has been documented in global and local studies, yet they are still not sufficiently protected on a global scale. Crete (Greece), a Mediterranean hotspot is a continental island, renowned for its diverse geology, ecosystems and endemicity of flora and fauna, with many studies on all of the above disciplines dating back to the 19th century. Here we investigate the conservation status of the Cretan Arthropods using Preliminary Automated Conservation Assessments (PACA) and the overlap of Cretan Arthropod distributions with the Natura 2000 protected areas. In order to perform this analysis, we assembled occurrences of the endemic Arthropods in Crete located in the collections of the Natural History Museum of Crete together with literature data. These assessments resulted in 75% of endemic Arthropods as potentially threatened. The hotspots of endemic and threatened taxa are distributed mostly on the mountainous areas where the Natura 2000 protected areas have great coverage. Yet human activities have significant impact even in those areas, while some taxa are not sufficiently covered by Natura 2000. These findings call for countermeasures and conservation actions.
Menger curve and Spherical CR uniformization of a closed hyperbolic 3-orbifold
Authors: Ma jiming , Xie Baohua
Published: March 2023

Let G6,3= ⟨a0, · · · , a5|a3i = id, aiai+1 = ai+1ai, i ∈ Z/6Z⟩ be a hyperbolic group with boundary the Menger curve. Granier [10] constructed a discrete, convex cocompact and faithful representation p of G6,3 into PU(2,1). We show the 3-orbifold at infinity of p(G6,3 )is a closed hyperbolic 3-orbifold, with underlying space the 3-sphere and singular locus the Z_3-coned chain-link C(6,-2). This answers the second part of Kapovich's Conjecture 10.6 in [14], and it also provides the second explicit example of a closed hyperbolic 3-orbifold that admits uniformizable spherical CR-structure after Schwartz's first example in [25].
Curcumin and omega-3 ameliorate experimental osteoarthritis progression in terms of joint pain and mitochondrial dysfunction
Authors: Jhun JooYeon , Lee Donghwan , Na Hyun Sik , Cho Keun-Hyung , Lee Seung Yoon , Lee Jeong Su , Kim Seok Jung , Cho Mi-La , Park Sung-Hwan
Published: March 2023

Background
Osteoarthritis (OA), a chronic degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Curcumin and omega-3 have been used as dietary supplements for OA due to their anti-inflammatory and antioxidant properties. However, there is no evidence demonstrating a synergistic effect in OA. The current study aimed to investigate the therapeutic effects and underlying mechanism of a combination of curcumin and omega-3 in the treatment of OA.
Methods
Wistar rats were injected with monosodium iodoacetate to induce OA. Oral treatments of a vehicle, curcumin, curcumin and omega 3, or celecoxib were administered. Pain was analyzed according to the paw withdrawal latency, paw withdrawal threshold, and weight bearing ability. The joint was isolated from OA rats, and cartilage damage was evaluated using histomorphological techniques, the Mankin scoring system, and micro computed tomography analysis. Protein expression in the joint was examined using immunohistochemistry. The expression levels of catabolic markers were measured in curcumin and omega-3-treated OA chondrocytes.
Results
The OA animal model revealed diminished pain and cartilage conservation in response to the combined treatment. mRNA levels of matrix metalloproteinase 1 (MMP1), MMP3, and MMP13 were reduced in interleukin-1 beta-simulated human OA chondrocytes. Additionally, mitochondrial markers, cytochrome c oxidase 4, and TOMM20, were increased by the combination treatment.
Conclusions
These findings suggest promising therapeutic outcomes for the combined treatment of curcumin and omega-3 in OA patients.
Knowledge Framework Construction, Question Bank Promotion and Case Collection Driving on Grade Point Average and the Medical Licensing Examination
Authors: Qu Xiaoying , Cao Jinfeng , Huang Xiaoming , Li Zhuoquan
Published: March 2023

Objectives:Passing the medical licensing exam is a primary objective of MBBS (Bachelor of Medicine and Bachelor of Surgery) education and a major milestone in medical careers. This study aimed to explore the influence of various learning methods on the participation and pass rate of the license exam.
Methods: Three different study tactics were employed among two grades (A: n=15 and B: n=23) of MBBS students. These tactics were Knowledge framework construction (KFC), Question bank promotion (QBP) and Case collection driving (CCD).
Results: The percentage distribution of KFC, QBP and CCD at the 1st AY in grade A was 40.0%, 40.0% and 20.0%, respectively, while at the 6th AY, it was 33.3%, 40.0% and 26.7%. At the 1st AY in grade B, the distribution was 52.2%, 21.7% and 26.1%, and at the 6th AY, it was 13.1%, 47.8% and 39.1%. The overall participation and pass rates in grade A were higher than in grade B (73.3% to 78.3%, 53.3% to 60.9%). The pass rates of participants in KFC, QBP and CCD in grade A were 50.0%, 100.0%, 66.7%, respectively, and in grade B were 0.0%, 100.0%, 57.1%. The grade point average (GPA) was significantly higher in QBP (4.2 ± 0.4) than in KFC (3.8 ± 0.2), but not in CCD (3.9 ± 0.4).
Conclusions: The pass rate of MBBS students in the license exam was higher in grade A than in grade B, and the study method of QBP had a better effect on the passing rate and GPA than KFC and CCD.
Distal Radius Reconstruction Using Proximal Non-Vascularized Fibula Graft in a Patient during the Syrian Conflict: A Case Study on Treatment Outcomes
Authors: Khatib Mohamad , Hasani Ibrahim
Published: March 2023

Giant cell tumor (GCT) is a bone tumor that is encountered frequently and can have both benign and aggressive characteristics. It is commonly found in individuals between the ages of 20 and 45, with a slightly higher incidence in females. A 22-year-old female presented with a progressively increasing painful and tender lump in the distal forearm, along with restricted wrist movements and inability to use her right hand. The patient's medical history was complicated by the ongoing Syrian conflict, which limited her access to medical care and resources. Physical examination showed a large lump in the distal radius and severely restricted pronation and supination, additionally, Plain radiographs and computerized tomography (CT) were suggestive of an aggressive giant cell tumor (GCT) of the proximal humerus, which was confirmed on histopathological examination. After appropriate investigation, we decided to proceed with En bloc resecting and reconstructing the resultant defect with a proximal non-vascularized fibula graft. Despite the challenges posed by the Syrian conflict, our surgical intervention successfully restored the patient's arm function and provided her with a positive outcome. This case highlights the importance of adapting to difficult circumstances in order to provide necessary medical care to patients affected by conflict and other adverse situations.
Horizontal Mergers and Innovation with Knowledge Spillovers
Authors: Hwangbo Changwoo , Lee Jihong
Published: March 2023

We introduce knowledge spillovers in a model of innovation competition à la Federico et al. (2017) and Denicolò and Polo (2018), which otherwise features horizontal mergers that harm innovation due to the business stealing effect. With knowledge spillovers, competition discourages investment in R&D due to free-riding, and by internalizing such externalities, a merger can improve the incentives for innovation. Horizontal mergers raise (reduce) innovation if the spillover effect is large (small), in contrast with the standard account of spillover effects on mergers.
JEL codes: G34, L13, L40, O30
Lumican promotes proliferation, migration and invasion of gastric cancer through ERK pathway
Authors: liu Guangxi , Li Xin , Shen Xiaobing
Published: March 2023

Purpose
To clarify the molecular mechanism of lumican's effects on gastric cancer cell proliferation, migration, and invasion.
Methods
qRT-PCR was used to analyze lumican expression in gastric cancer tissues and cell lines. Small interfering RNA (siRNA) transfection and lentivirus infection have been used to produce lumican knockdown or overexpression gastric cancer cell models from screened cell lines. CCK-8, wound healing assays, and transwell assays were performed to confirm the effect of lumican on gastric cancer cell’s proliferation, migration, and invasion. To further evaluate the potencial mechnism of lumican on gastric cancer cells, bioinformatic prediction and western blot experiment were used to identify and confirm its related signaling pathway.
Results
Using MGC-803 and AGS gastric cancer cells, lumican knockdown or overexpression was achieved. Overexpression of lumican increased MGC-803 and AGS gastric cancer cell proliferation, migration, and invasion, whereas knockdown decreased them. The expression levels of ERK and p-ERK, two key proteins of the ERK pathway, were significantly decreased in MGC-803 and AGS cells with lumican knockdown, while the opposite result was observed with lumican overexpression; the expression levels of MEK and p-MEK, two key proteins of the MEK pathway, were not significantly changed with lumican knockdown or overexpression. GDC-0994, an ERK pathway inhibitor, restored ERK1/2 and p-ERK1/2 protein expression in MGC-803 and AGS cells overexpressing lumican.
Conclusion
Lumican was discovered in high levels in the tissues of patients with gastric cancer, and it promoted proliferation, migration, and invasion in gastric cancer cells. Lumican may impact the expression of two main proteins, ERK1/2 and p-ERK1/2, in the ERK signaling pathway rather than activating it via MEK, indicating that the pathway may be a therapeutic target for lumican overexpression in gastric cancer.
Highly Accurate Memristor Modelling Using Mos Transistor for Analog Applications
Authors: Soni K. , Sahoo Satyajeet
Published: March 2023

Memristor technology has grown at a breakneck pace over the last decade, with the promise to transform data processing and storage. A memristor is a non-linear electrical component with two terminals that connects electric charge and magnetic flux. The ability to store and process data in the same physical location is a fundamental benefit of memristors over traditional electrical components. It has a unique feature in that its resistance may be preset (resistor function) and then saved (memory function). Memristors, unlike other types of memory used in modern electronics, are stable and retain their state even if the device is turned off. In this work, a new highly accurate asymmetrical memristor is proposed for highly efficient analog applications. The proposed work used 5 Complementary metal-oxide-semiconductor (CMOS) devices in a parallel and series-connected manner. A bypass transistor is used to control the current flow between two terminals to perform a stable operation. A differential amplifier circuit is used to validate the proposed memristor performance. The proposed work is implemented using TSMC 45nm CMOS technology. This application consumes less power and has good performance when compared with conventional techniques. In this work, a 1V power supply occupies a 67.5 µm2 layout area. The experimental results are improved when compared with the existing circuit.
Systemic Practice in the Business Mountain Models nexus Internet of Things
Authors: Covaci Brindusa , Covaci Mihai
Published: March 2023

The paper proposes an aggregate index for systemic practice regarding mountain business development through the Internet of Things (IoT) and Information and Communication Technology (ICT). The paper presents an aggregate index, build from unequal indices, which sustain systemic practice of the business development in the mountain area, especially through ICT and IoT. The proposed model is predictive. The paper contains relevant data related to the Eurostat index Business Demography and activities of ICT and IoT for some European mountain areas. Data have been processed and simulated in Excel, SPSS, and Make fractal software. The article performed exploratory and quantitative analysis, using statistics and forecasting techniques based on ANOVA. The indicator, the first in the specific literature and its application, develop considerably systemic practice of the mountain business in Europe, in the 2022 context, declared by the United Nations as the ”International Year of Sustainable Mountain Development”.
From the consumers’ side: Determining students’ perception and intention to use ChatGPT in Ghanaian higher education
Authors: Bonsu Emmanuel Mensah , Baffour-Koduah Daniel
Published: March 2023

The advent and development of technologies such as artificial intelligence have created benefits and challenges for educational stakeholders. Artificial intelligence, such as OpenAI’s Chat Generative Pre-trained Transformer (ChatGPT), has brought new benefits, challenges and pressures for higher educational institutions. There are relatively few reports of how students perceive and intend to use ChatGPT. Taking cognizance of these, the research explored students’ perceptions and intentions to use ChatGPT in their higher education. Guided by two hypotheses and a mixed-method approach, the analysis revealed no statistical relationship between perception and intention to use ChatGPT. Despite this statistical relationship, the study reported students’ positive perceptions towards ChatGPT, and intentions to use ChatGPT and advocated its adoption in education. Based on these findings, the study offers implications for educational practices and further research.
Physical aspects of chemical carcinogenesis
Authors: A.P Batyanov
Published: March 2023

This study investigated the effects of chemical carcinogenesis induced by 7,12-dimethylbenz(α)anthracene (DMBA) in mice. The respiratory activity of isolated mitochondria in mouse livers was investigated at various times after the subcutaneous administration of DMBA. Our findings indicated that DMBA derivatives did not exhibit damaging effects on mitochondrial membranes. On the contrary, they showed a stimulating effect on the phosphorylation process compared with the control. This paper discusses the possible role of coherent electromagnetic radiation in biological systems. Additionally, data on the non-chemical interactions between isolated mitochondria and the material (plexiglass and quartz) of the incubation cells were considered. Carcinogenesis was previously considered an exclusive process of biochemical and genetic disorders.However, recent studies have increasingly focused on the physical aspects of carcinogenesis, such as the influence of various wavelengths of electromagnetic radiation on biological systems, the special energy organization of the intracellular space associated with the architectonics of mitochondria and microtubules, and the generation of coherent electromagnetic waves. It was assumed that the biological features of the malignant cells were due to the violation of the electrodynamic parameters of the intracellular space, and the initiating factor was the intrinsic emission of carcinogenic substances. The results of this study indicated that non-chemical factors influenced the mitochondrial poly-enzyme system and confirmed the importance of the non-chemical effect of a carcinogen on bio-objects by examining respiration and phosphorylation of isolated mouse liver mitochondria at various times after the subcutaneous injection of DMBA.
Exploratory Study Regarding the Status of Women's Educational Administrative Support Organizations
Authors: Irby Beverly , Brown Genevieve
Published: March 2023

Women's support organizations should serve as vehicles for the growth of women at initial administrative career stages as well as for women in top level positions.
What Does Emotional Intelligence and Gender Have to Do with Leadership Effectiveness "¦.Or Does It?
Authors: Condren Tammy , Martin Barbara N. , Hutchinson Sandy
Published: March 2023

The purpose of this descriptive study was to examine the relationship between the emotional intelligenceand gender of the principal, and teacher's perceptions of the principal's leadership effectiveness. Theresearcher administered the Emotional IQ Test (Jerabek, 1998) to 32 randomly selected principals. Onehundred and sixty randomly selected teachers in the buildings of these administrators then took the observerform of the Leadership Practices Inventory (LPI) (Kouzes & Posner's, 2001) to measure the leader'sperceived effectiveness. The leadership practices and gender were correlated to the two aspects of emotionalintelligence to determine possible relationships. Findings show that principals with higher emotionalintelligence are perceived to be more effective. Overall, women have a higher EQ than their malecounterparts and the building level assignment had a significant impact on how principals were perceived.