bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanomaterials-mediated lysosomal regulation: a robust protein-clearance approach for the treatment of Alzheimer’s disease
Authors: Hao Mengqi , Chu Jianjian , Zhang Tinglin , Yin Tong , Gu Yuankai , Liang Wendanqi , Ji Wenbo , Zhuang Jianhua , Liu Yan , Gao Jie , Yin You
Published: April 2024

Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins, including amyloid plaques and intracellular tau tangles, primarily within the brain. Lysosomes, crucial intracellular organelles responsible for protein degradation, play a key role in maintaining cellular homeostasis. Some studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases, including Alzheimer’s disease. Restoring the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s disease. Currently, the efficacy of drugs in treating Alzheimer’s disease is limited, with major challenges in drug delivery efficiency and targeting. Recently, nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical properties. This review aims to provide a comprehensive overview of recent advances in using nanomaterials (polymeric nanomaterials, nanoemulsions, and carbon-based nanomaterials) to enhance lysosomal function in treating Alzheimer’s disease. This review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal function. In conclusion, this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s disease. The application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.
Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism
Authors: Canovai Alessio , Williams Pete A.
Published: April 2024

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues. Pyrroloquinoline quinone is present in the diet being available in foodstuffs, conferring the potential of this compound to be supplemented by dietary administration. Pyrroloquinoline quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction, growth, and immunity resulting from the dietary absence of pyrroloquinoline quinone, and as such, pyrroloquinoline quinone has been considered as a “new vitamin.” Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established, the wide range of benefits for health provided has been reported in many studies. In this respect, pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts, thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian life. Through the regulation of different metabolic mechanisms, pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and death. Pyrroloquinoline quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration, although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully elucidated. Here, we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological contexts. In addition, we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.
A descriptive study of new drug approvals during 2017–2021 and disease morbidity and mortality patterns in India
Authors: Gupta Urvashi , Kamath Ashwin , Kamath Priyanka
Published: April 2024

Aim:

Studies show the presence of a mismatch between drug research and disease burden. A study conducted in the European Union found that new drug development was restricted to certain diseases. A study of biosimilar approvals in India found that 87% of drugs were for treating noncommunicable diseases. This study aimed to determine the new drugs approved in India from 2017 to 2021 and the top ten causes of morbidity and mortality and detect the presence of any discordance between these.

Methods:

A descriptive study was conducted using data on new drug approvals accessed from the Central Drugs Standard Control Organization website. The top ten causes of mortality and morbidity in India from 2015 to 2019 were identified from the Global Burden of Diseases database. Descriptive statistics were used to compare the drug approvals and the leading diseases.

Results:

One hundred twenty-six drugs were approved during the study period. Antineoplastic drugs constituted 19.84% of the approvals, antimicrobials 18.25%, and cardiovascular drugs 9.52%. Ischemic heart disease and chronic obstructive pulmonary disease were the two leading causes of morbidity and mortality. Diarrheal diseases, lower respiratory tract infection, and drug-susceptible tuberculosis were among the top ten causes. Ten antibacterials, including four antitubercular drugs, were approved during this period. Two drugs were approved for rare diseases.

Conclusion:

Our study showed that the drugs approved were largely in line with the prevalent disease burden, and there was no significant discordance observed. Some diseases, such as ischemic stroke/intracranial hemorrhage, require further efforts in bringing forth newer pharmacotherapy options.
Impact of accreditation on registered ethics committees in terms of quality and governance in India: A cross-sectional study
Authors: Dakhale Ganesh N. , Kalikar Mrunalini Vinay , Giradkar Akhil Bhagwan
Published: April 2024

Background:

Ethics Committee accreditation is a process to assess the performance against a set of standards. Very few studies have shown that process of accreditation results in the improvement of the overall functioning of ECs. in terms of quality and governance. Hence, the present study was planned to evaluate the impact of accreditation on registered EC in terms of quality and governance and to compare functioning of accredited versus non accredited EC in terms of quality and governance.

Materials and Methods Study Design:

This was a cross sectional, observational, questionnaire-based survey conducted on 28 registered Ethics Committee in India after approval from the Institutional Ethics Committee.

Results:

Accredited EC’s (n = 12) were compared for NABH standard for accreditation before and after accreditation in terms of percentage. It was found that majority of the standards related to structure and composition, adherence to specific policies , completeness of review and after approval process were met by majority of EC’s after accreditation. Only a few EC ‘s fulfilled some of the criteria before accreditation. There was a statistically significant difference with reference to adherence to specific policies by accredited and non-accredited EC’s like updating SOP according to changing requirements (P < 0.0237), process for preparing SOP (P < 0.0237), categorization of review process mentioned in SOP (P < 0.0237) procedure to be followed for vulnerable population (P < 0.0103) , process of handling issues related to complaints by participants and other stakeholders violation (P < 0.0103) etc.

Conclusion:

Accreditation results in improving of EC functioning in terms of quality and governance.
Cosmeceuticals in hyperpigmentary disorders
Authors: Kiruthika Subburaj , Sejal Jain , Keshavmurthy Vinay
Published: April 2024

Cosmeceuticals are hybrids between cosmetics and pharmaceuticals containing ingredients that modify the skin’s functions and enhance its appearance. They are a bridge between drugs and cosmetics for minor skin ailments. The lack of proper regulatory standards for cosmeceuticals makes it very important for the dermatologists to educate the patient regarding their safety, or consequences of lack of knowledge thereof. In hyperpigmentation disorders, cosmeceuticals specifically target melanocytes and block the important regulatory steps in melanin synthesis, especially tyrosinase. The various agents include arbutin, bakuchiol, ferulic acid, kojic acid, licorice root extract, nicotinamide, plant extracts, resorcinol, retinol, sunscreens, thiamidol, and vitamin C. Plant extracts have minimal side-effects and are gaining popularity. They include aloe vera extract, cinnamic acid, coffeeberry, flavonoids, grape seed extract, green tea extracts, marine algae extract, mulberry extract, N-acetyl glucosamine, orchid extract, pycnogel, soy and umbelliferone. There is a requirement for large randomised controlled trials to establish their efficacy and adverse effects. Patient follow-up and compliance are the cornerstones of any skin therapy as any cosmeceutical use can produce gradual results when compared to conventional therapies. The PubMed database was searched using ‘hyperpigmentation disorders’ OR ‘melasma’ AND ‘cosmeceuticals’ as keywords. Abstracts were screened to include studies in the English language and those pertaining to the use of cosmeceuticals in hyperpigmentary disorders. In this review, we summarise the existing literature on the utility of cosmeceuticals in the treatment of hyperpigmentary diseases.
A randomized comparative study of efficacy of microneedling with 5% 5-FU and microneedling with 0.1% tacrolimus in treatment of vitiligo
Authors: Passi Shanta , Punia Snehlata , Vinayak Garima
Published: April 2024

Background: Vitiligo is an amelanotic disorder affecting 0.5% to 2% of the world’s population. Several treatment modalities have been tried and it has been reported that combination therapies augment the repigmentation in vitiligo. Objective: To compare the efficacy of microneedling with 5% 5-FU and microneedling with 0.1% tacrolimus in treatment of vitiligo. Methods: Twenty-five patients with localized stable vitiligo were subjected to microneedling of two patches with dermaroller of size 2 mm, then application of 5-fluorouracil to one patch and tacrolimus on the other patch. This procedure was repeated every month for maximum 6 months (six sessions). The patients were followed up for 3 to 4 months after the last session. Results: The overall repigmentation was slightly higher in 5-FU treated patches than tacrolimus treated patches. Very much improved to much improvement in VASI score was seen in 14 patches (64%) in 5% 5FU treated patches and 11 patches (44%) in 0.1% tacrolimus treated patches. Improved and minimally improved lesions, that is, eight patches (32%) and 11 patches (44%) respectively treated with 5% 5FU and 0.1% tacrolimus. Three patients (12%) showed no improvement. However, there was significant difference between the two drugs, regarding inflammation, ulceration, and hyperpigmentation which occurred with 5-FU. Conclusion: Microneedling combined with 5% 5-fluorouracil or tacrolimus is effective though 5-FU achieved better repigmentation.
Pigmentary mosaicism and extracutaneous defects
Authors: El-Komy Mohamed H.M. , EL-Nabarawy Eman A. , Abdelkader Heba A. , Abdel-Halim Mona R.E. , EL-Aguizy Randa S.
Published: April 2024

Progressive cribriform and zosteriform hyperpigmentation (PCZH) is an uncommon disorder of pigmentation that is believed to be a result of pigmentary mosaicism. In this report, we describe a child with congenital nevus depigmentosus and low intelligence who later developed PCZH by the age of 5 years.
Intradermal platelet-rich plasma vs. 1064 nm Q switched Nd-YAG laser (Qs Nd-YAG) in the treatment of resistant melasma − A split face comparative study in Indian subjects
Authors: Rout Aradhana , Mani Siddharth , Pandey Ashish Kumar
Published: April 2024

Background: Melasma is a common dermatosis in both men and women showing varying degrees of success with treatment. Relapse of pigmentation in melasma after treatment is a common problem in dark skin types that necessitates treatment with novel alternative modalities with better efficacy. Aim: To compare the effectiveness of intradermal platelet-rich plasma vs. 1064 nm Qs Nd-YAG in patients of melasma in a split face comparative study conducted in a Dermatology center over a period of 6 months. Methods: A comparative split face prospective study of 20 female patients of Fitzpatrick skin type IV-V with mixed resistant type of melasma and bilateral involvement of the face were enrolled for the study. Platelet-rich plasma (PRP) was injected intradermally at 2 weeks interval for seven sittings in one half of the face and Qs Nd-YAG was done every week for 12 weeks on the other half of the face. The results were assessed clinically by Hemi-modified MASI score at the end of every 2 weeks. Patients were counselled to continue strict sun protection measures. Patient satisfaction was noted at baseline, 4 weeks, 8 weeks, and 12 weeks. Patients were followed up for 3 months to see for any relapse of the pigmentation and the follow-up results were compared for both modalities of treatment. Results: Comparison of Hemi-mMASI score in both groups showed statistically significant improvement of pigmentation on completion (i.e., at the end of 12 weeks) and not in successive follow-up results every 2 weeks. The subjective assessment was made by PGAIS (Physician global aesthetic improvement scale). Patient satisfaction levels (assessed by SGAIS-Subject global aesthetic improvement scale) also showed significant improvement in successive weeks of treatment in both the groups. Few patients had mild redness and burning post procedure which resolved spontaneously after few hours. Patients were followed up for 3 months to see for reappearance of melasma. The split side treated with PRP showed less reappearance of pigmentation than the side treated with Qs Nd-YAG laser. Conclusion: From this study we concluded that PRP shows a significant improvement in pigmentation in mixed resistant melasma in 12 weeks of treatment with less chances of relapse after 3 months of treatment as compared with Qs Nd-YAG laser. PRP may be used as a first-line treatment in mixed, resistant melasma cases and also as an excellent maintenance therapy in these cases. Limitations: Desired sample size could not be achieved and a longer follow-up period of 6 months could not be materialized.
Mysterious discoloration of nails in both hands, particularly thumbs alone
Authors: Jain Akshay Kumar , Saini Shivani
Published: April 2024

Preterm babies have immature immunity and skin barrier functions. To cope up with these, many times they are kept under observation in neonatal care unit (NICU) for months until they attain their normal physiological age, weight, and immune functions along with other vital capacities. We are reporting such a curious case of 1-month-old preterm child who presented with the sequence of blackish blue to yellowish discoloration of thumb nails in both the hands.
Clinico-histopathological and dermoscopic features of Becker nevus
Authors: Patil Ankita , Kumar Ajay , Dalave Kalyan , Deora Mahendra S , Pol Devayani
Published: April 2024

Background:

Becker nevus (BN), a common nevoid hamartoma, presents as a hypermelanotic often hypertrichotic plaque localized to the chest, shoulder, or back in the first two decades of life.

Aims:

The aim of the study was to evaluate clinicohistopathological and dermoscopic findings of BN in the Indian population.

Methods:

Thirty-five clinically diagnosed cases of BN were enrolled. Sample characteristics, clinicohistopathological findings, dermoscopic findings, and developmental abnormalities were noted and an observational analytical study was carried out.

Results:

The mean age of the patients was 18.9 years and 28 (80%) were Males. BN was present since birth in 12 (34.3%), developed in the first decade in 5 (14.3%), and in the second decade in 18 (51.4%). Common sites included the chest in 10 (28.6%), the face in 8 (22.9%), and the upper limb in 7 (20%). Hypertrichosis was observed in 24 (68.6%) and acneiform lesions in 2 (5.7%). Twenty-two (62.9%) patients had right-sided lesions. No developmental abnormalities were detected. Skin biopsy findings included hyperkeratosis in 25 (71.4%), acanthosis in 32 (91.4%), elongation of rete ridges in 32 (91.4%), basal layer pigmentation in 35 (100%), and smooth muscle hyperplasia in 4 (11.1%) patients. Dermoscopic findings included reticular brown lines (pigmentation network) in 32 (91.4%), perifollicular white color (perifollicular hypopigmentation) in 27 (77.1%), skin furrow hypopigmentation in 17 (48.6%), and focal hypopigmentation in 15 (48.6%) cases.

Conclusions:

Onset at birth and facial lesions are common in those of Indian ethnicity, while developmental abnormalities associated with BN are infrequent.
Primary localized cutaneous amyloidosis − a review
Authors: Somani Vijay K. , Somani Anirudh , Sarkar Rashmi
Published: April 2024

Amyloidosis describes a group of diseases characterized by abnormal extracellular deposition of a fibrillar protein in tissues. It comprises of a spectrum of diseases ranging from a mild asymptomatic cutaneous involvement to a progressive life-threatening multisystem disorder. Primary localized cutaneous amyloidosis (PLCA) is characterized by pruritus, hyperpigmentation, and lichenification. Demonstration of amyloid in dermal papillae by various techniques confirms the diagnosis. Three types are described, macular, lichen/papular, and nodular. Majority of cases of PLCA are sporadic but an autosomal dominant family history may be present in up to 10% of cases. Exact pathogenesis is not elucidated yet, but several factors like friction, sunlight, genetics, atopy, immune dysregulation have been implicated. Pathogenic mutations in oncostatin M receptor and the interleukin (IL)-31 receptor A gene (IL31RA) have an important role to play in the pathogenesis of both familial and sporadic PLCA. Nodular amyloidosis, the rarest type of PLCA, is known to progress to systemic amyloidosis in 7% to 15% of cases, hence a long-term follow up is recommended. The plethora of treatment options reported to be beneficial in cutaneous amyloidosis underscores the fact that none of the modality is universally effective.
Surgical and critical care management of earthquake musculoskeletal injuries and crush syndrome: A collective review
Authors: Abu-Zidan Fikri M. , Jawas Ali , Idris Kamal , Cevik Arif Alper
Published: April 2024

Earthquakes are unpredictable natural disasters causing massive injuries. We aim to review the surgical management of earthquake musculoskeletal injuries and the critical care of crush syndrome. We searched the English literature in PubMed without time restriction to select relevant papers. Retrieved articles were critically appraised and summarized. Open wounds should be cleaned, debrided, receive antibiotics, receive tetanus toxoid unless vaccinated in the last 5 years, and re-debrided as needed. The lower limb affected 48.5% (21.9%–81.4%) of body regions/patients. Fractures occurred in 31.1% (11.3%–78%) of body regions/patients. The most common surgery was open reduction and internal fixation done in 21% (0%–76.6%), followed by plaster of Paris in 18.2% (2.3%–48.8%), and external fixation in 6.6% (1%–13%) of operations/patients. Open fractures should be treated with external fixation. Internal fixation should not be done until the wound becomes clean and the fractured bones are properly covered with skin, skin graft, or flap. Fasciotomies were done in 15% (2.8%–27.2%), while amputations were done in 3.7% (0.4%–11.5%) of body regions/patients. Principles of treating crush syndrome include: (1) administering proper intravenous fluids to maintain adequate urine output, (2) monitoring and managing hyperkalemia, and (3) considering renal replacement therapy in case of volume overload, severe hyperkalemia, severe acidemia, or severe uremia. Low-quality studies addressed indications for fasciotomy, amputation, and hyperbaric oxygen therapy. Prospective data collection on future medical management of earthquake injuries should be part of future disaster preparedness. We hope that this review will carry the essential knowledge needed for properly managing earthquake musculoskeletal injuries and crush syndrome in hospitalized patients.
Pattern and clinical profile of patients with ocular trauma presenting to the emergency department of a teaching hospital in India: A prospective observational study
Authors: Sahu Sandip Kumar , Radhakrishnan Rakesh Vadakkethil , Mohanty Chitta Ranjan , Parija Sucheta , Palanisamy Shanmugasundaram , Mishra Priyadarshini , Sadangi Debasish
Published: April 2024

OBJECTIVES:

One major contributor to avoidable ocular morbidity is ocular trauma (OT). The study aimed to document the epidemiological factors, pattern of injury, and outcome among patients with OT presenting to the emergency department (ED).

METHODS:

This was a prospective observational study conducted in the ED of a tertiary care teaching hospital in Eastern India after due approval from the institutional ethics committee. The data were collected during the period from March 2021 to February 2022. Data pertaining to age, sex, type of injury, mechanism of injury, time and place of injury, details of tissue involvement, visual acuity, any prior history of injury, initial diagnosis, and management were noted. To estimate the severity of the injury and the probable visual outcome, we calculated through OT score (OTS), including one raw score and OTS. Statistical analysis was performed using the R, version 4.6.1.

RESULTS:

A total of 180 patient’s data were included for final analysis. The median (interquartile range) age of the patients was 32 (24–45) years. The majority were males (n = 147 [81.6%]) with a male–female ratio of 4.5:1. Road traffic accidents (RTA) were the common cause of injury (n = 122 [67.7%]). Unilateral eye involvement was the most common (n = 147 [81.6%]). In the pattern of injury, most of the patients sustained closed globe injuries (CGIs) (n = 158 [87.7%]). Among the CGIs, injury to the ocular adnexa and conjunctiva (n = 141 and 127, respectively) was the most common. Injury to the retina and choroids occurred in 20 (11%) patients. The vision was not affected in most of the cases (n = 125 [69.4%]) with a visual acuity of > 6/18. The majority (n = 120 [67%]) of the patients had an OTS of grade-4, followed by grade-2 (n = 22 [12%]). Most of the patients required only medical management (n = 100 [56%]), whereas 77 (43%) patients required surgical interventions.

CONCLUSION:

OT was a common presentation in the ED. Male patients with monocular injuries involved in RTAs were mostly affected. The vision was preserved in most of the cases.
Ventilatory load reduction by combined mild hypothermia and ultraprotective mechanical ventilation strategy in severe COVID-19-related acute respiratory distress syndrome: A physiological study
Authors: Cruces Pablo , Moreno Diego , Reveco Sonia , Ramírez Yenny , Díaz Franco
Published: April 2024

We report the feasibility of a combined approach of very low low tidal volume (VT) and mild therapeutic hypothermia (MTH) to decrease the ventilatory load in a severe COVID-19-related acute respiratory distress syndrome (ARDS) cohort. Inclusion criteria was patients ≥18-years-old, severe COVID-19-related ARDS, driving pressure ∆P >15 cmH2O despite low-VT strategy, and extracorporeal therapies not available. MTH was induced with a surface cooling device aiming at 34°C. MTH was maintained for 72 h, followed by rewarming of 1°C per day. Data were shown in median (interquartile range, 25%–75%). Mixed effects analysis and Dunnett’s test were used for comparisons. Seven patients were reported. Ventilatory load decreased during the first 24 h, minute ventilation (VE) decreased from 173 (170–192) to 152 (137–170) mL/kg/min (P = 0.007), and mechanical power (MP) decreased from 37 (31–40) to 29 (26–34) J/min (P = 0.03). At the end of the MTH period, the VT, P, and plateau pressure remained consistently close to 3.9 mL/kg predicted body weight, 12 and 26 cmH2O, respectively. A combined strategy of MTH and ultraprotective mechanical ventilation (MV) decreased VE and MP in severe COVID-19-related ARDS. The decreasing of ventilatory load may allow maintaining MV within safety thresholds.
Paulina’s Inspiration for Radical Change in The Winter’s Tale
Authors: Ringwood Frances
Published: April 2024

In the same way that Boethius is a prisoner of his mind more so than the cell that confines him in his De consolation philosophiae (c. 524), Hermione in The Winter’s Tale (c. 1609–11) is a mind restricted within a body when she chooses to adopt the guise of a statue. The following article situates Hermione’s response to her husband’s tyrannical treatment within feminist criticism of the play and new research published on its sources in order to argue that Paulina embodies a version of Boethius’s Lady Philosophy. The idea of the body as a prison is a major trope underpinning Hermione’s miraculous revivification, but she is not the only prisoner released by Paulina’s ministrations. Leontes’s recalcitrant jealousy and its aftermaths are also mental afflictions from which he needs to be released. Ultimately, Paulina’s embodiment of an insubstantial personification allows her to issue a challenge to the authority of a man in a way that makes her an inspiring feminist, and an icon for life-affirming, regenerative friendship between women.
PENENTUAN PICTURE DAN OPERASI PICTURE UNTUK PRESENTASI GRUP 〈a,b|〖a^2,b〗^3,[a,b]〉
Authors: Mardianto Dedi
Published: April 2024

Pada penelitian ini membahas tentang picture dan operasi picture untuk presentasi grup. Diberikan presentasi grup  dan . Dari presentasi grup ini akan dibuat picture dan kemudian diterapkan operasi-operasi pada picture tersebut.
USULAN PENENTUAN TITIK LOKASI PUSAT DISTRIBUSI VAKSIN COVID-19 DI JAWA BARAT
Authors: Lestari Fitria Dewi , Rismayanti Zani , Wicaksono Bagas , Fauzi Muchammad
Published: April 2024

COVID-19 became a pandemic that occurred in many countries around the world including Indonesia. On April 4, 2021, confirmed positive cases in Indonesia were recorded at 1,534,255 cases. West Java occupies the highest position recorded on April 10, 2021 amounting to 256,834 cases until July 3, 2021 positive cases have reached 2,228,938 positive cases of Covid-19 virus. Various ways have been done by the government to reduce the growth rate and spread of the Covid-19 virus, one of which is the provision of vaccines to the community. Distribution of vaccines needs to be done as quickly as possible, so an appropriate distribution strategy is needed. This study aims to determine the location of the Covid-19 vaccine distribution center in West Java. The method used in determining the location point of the vaccine distribution center is the Center of Gravity method. Based on the calculations obtained the coordinate point of the location of the Covid-19 vaccine distribution center in West Java is -6.83041 and 107.73030 with a total distribution cost of Rp31,939,000. The location of the vaccine distribution center provides a greater cost value compared to the cost in the initial condition of Rp 30,091,000. In terms of distance, the location of the latest distribution center resulted in a smaller distance of 3055.3 km compared to the initial condition with a total distance of 3389.8 km. The distance produced by the distribution center is shorter so that it will increase the efficiency of delivery time which will make the distribution process faster
ANALISIS BIAYA TRANSPORTASI ES KRIM DI PT.XYZ
Authors: Simbolon Armando Sun Angle , Dafa Moh , Purwana Aga
Published: April 2024

In the distribution process a company usually has obstacles to the delivery of goods to be sent to retailers, usually the constraints occur in large transportation costs for one distribution, which results in large costs. The right method to solve this problem is Economic Scale and Economic of Distance, due to a decrease in production costs per unit in an enterprise accompanied by an increase in production volume or output. So, the larger the company, the lower the cost of production per unit of product that will be produced as well as for the more goods transported, the smaller the cost per unit I am
PENINGKATAN HASIL BELAJAR SISWA KELAS III SDN KESAUD KOTA SERANG PADA MATA PELAJARAN MATEMATIKA MELALUI METODE DEMONSTRASI
Authors: Andini Andini , Hidayat Amat , Mubarok Ahmad
Published: April 2024

This study aims to determine the learning outcomes of third grade students at SDN Kesuad Serang City in mathematics through the demonstration method. This research uses a qualitative method with a classroom action approach (CAR) carried out collaboratively and in two cycles. The results showed that the average value of learning outcomes in the first and second cycles of the first and second meetings obtained an average value of 58.5 with a percentage increase of 68.5% and the second cycle obtained an average value of 72.7, with a percentage value achievement of 83.5%, then there is an increase in student learning outcomes. Likewise, the results of student observations showed an increase in student participation and activity in cycle I and cycle II by 90%. It can be concluded that the application of the demonstration method can improve student learning outcomes in Mathematics
BELAJAR MATEMATIKA MELALUI FUN COOKING PADA ANAK USIA DINI
Authors: Pratiwi Nadya , Islam Rahma Mujahidatul , Anggraeni Ira
Published: April 2024

This paper aims to determine the extent of the influence of fun cooking in improving mathematics learning in early childhood. This article is based on the assumption that learning in early childhood will be more meaningful by playing and having fun for children. In general, mathematics is introduced to the process of counting, measuring, and weighing. Fun cooking was chosen for the method of introducing mathematics to early childhood because it can improve children's mathematical logical abilities in the cooking process such as counting, measuring and weighing food ingredients. The findings from this article are expected to help teachers in implementing fun mathematics learning for early childhood
PEMBELAJARAN MATEMATIKA TERPADU PADA ANAK USIA DINI
Authors: Maulida Ulfa , Yuliani Riska , Anggraeni Ira
Published: April 2024

This paper aims to analyze integrated mathematics learning in early childhood education. Education for early childhood is one of the processes of growth and development that has a unique nature so that it has growth and development that is in accordance with the needs of the level of growth and development. This article is based on the assumption that early childhood should not be taught to count. Researchers used a meta-analysis of previous research and literature on mathematics learning in early childhood education. The findings from this article are expected to have a positive impact on the growth and development of early childhood. It is also hoped that learning mathematics in early childhood can be carried out with concepts that are truly in accordance with the characteristics of early childhood learning
STRATEGI PEMBELAJARAN PENDIDIKAN AGAMA ISLAM PADA JENJANG SEKOLAH DASAR
Authors: Mutaqin Mumu Zainal
Published: April 2024

This study aims to explore the potential of Islamic religious education teachers at the elementary school level because their implementation only pays attention to cognitive aspects rather than growing awareness of Islamic religious values. as well as neglecting the development of affective and conative volutive aspects, namely the will and commitment to practice the values of religious teachings. The substance of Islamic religious education is manifested in speech, attitudes and behavior, but until now learning has not affected the daily behavior of students. The research method used in this research is a qualitative approach with library research methods. Literature study is an activity that cannot be separated from research. Data collection techniques in library research can be done by reviewing books, journal articles, research reports, websites, newspapers, and magazines. Islamic religious education learning strategies can be implemented by applying an emotional atmosphere and social relations approach in classroom management. This approach is based on the views of clinical and counseling psychology. Because classroom management is a process of creating an emotional atmosphere and positive social relations in the classroom. This strategy recognizes the conditions of psychological development. The next strategy, using the media, is to include a brief description of the material being studied on power point and then provide a detailed explanation verbally. This is done when the teacher conducts learning in large or classical groups
UPAYA GURU PAI DALAM MENGATASI KESULITAN BACA TULIS HURUF HIJAIYAH PADA ANAK BERKEBUTUHAN KHUSUS
Authors: Hamdanah Hamdanah
Published: April 2024

The purpose of this study is for students to recognize hijaiyah letters, so that students will find it easier to learn to read and write verses of the Al-Qur'an. The purpose of this research is to find out the efforts of PAI teachers in overcoming difficulties in reading and writing hijaiyah letters in children with special needs at SD SKH Al-Ghisafa Labuan and to find out the inhibiting and supporting factors of Islamic education teachers in overcoming difficulties in reading and writing hijaiyah letters in children with special needs in SKH Al -Ghisafa Labuan. This research is a qualitative research type with a descriptive approach, checking the validity of the data is done by extending the observation and triangulation of the data. Data collection techniques were carried out by means of observation, interviews, documentation and literature study. The research informants are school principals and Islamic religious education teachers. The results of this study are as follows: Learning to read and write hijaiyah letters at SKh Alghisafa Labuan uses the Iqra' learning method. The material taught to children with mental retardation is flexible or adapts to students' abilities. AT SKH Alghisafa, the average mentally retarded child is still in the Iqra' stage. The efforts of PAI teachers in overcoming hijaiyah literacy difficulties for children with special needs are: Carrying out hijaiyah reading and writing activities on Monday and Friday mornings before studying, using various learning methods and the teacher asking parents to teach hijaiyah letters to students. her son at home
MENINGKATKAN KEMAMPUAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) MELALUI GERAK DAN LAGU PADA KELOMPOK A TK MARSUDI ASIH LARANGAN KOTA TANGERANG
Authors: Wahyuningtyah Tri , Afifah Afifah , Suryani Nyayu Yayu
Published: April 2024

The transition from the Covid 19 pandemic to a new normal life is an early routine for early childhood education. Clean and healthy living habits need to be formed from the age of kindergarten (TK). The purpose of this study was to determine the ability to implement clean and healthy living behaviors in group A children at Marsudi Asih Larangan Kindergarten, Tangerang City through the method of movement and singing. This research is classroom action research conducted in collaboration with colleagues through hands-on approaches and narrative analysis. The research data was collected from observation and reflection which was carried out through simulations of learning improvement results for two cycles. The cycle includes several stages such as: planning, implementing, observing and reflecting. The results of the Enhanced Learning simulation show that there are weaknesses and strengths in the Enhanced Learning simulation. The weakness lies in the teacher's technique in learning activities. The benefits are kid-friendly methods that make kids happy, creative, and productive. The method of moving through songs is proven to be able to improve children's ability to understand and demonstrate clean and healthy living behaviors: 69% developed as expected, 4% developed very well, so that initially the growth was only 13%. as expected
UPAYA MENINGKATKAN ASPEK NILAI AGAMA DAN MORAL MELALUI METODE BERCERITA ANAK USIA 5 – 6 TAHUN DI PAUD MADANI PARUNGPANJANG
Authors: Nurhayati Nurhayati , Yulianti Puji
Published: April 2024

This study aims to improve aspects of religious and moral values ​​through the storytelling method in PAUD Madani Parungpanjang. The research method used is Classroom Action Research. The population used in this study was 15 students consisting of 4 boys and 11 girls. Data collection techniques in this study used interview, observation and documentation techniques. While the data analysis technique is carried out in a qualitative and quantitative descriptive manner. Based on observations, when research showed an increase in aspects of religious and moral values ​​through the storytelling method in PAUD Madani Parungpanjang, this was evidenced by the pre-cycle with an average of 53.6 if the percentage reached 13%, in cycle I with an average of 74 if the percentage reached 26% and in cycle II with an average of 89.6 if the percentage reaches 60%. This is evidenced by the increasing aspects of religious and moral values ​​through the question-and-answer method at PAUD Madani Parungpanjang
EFEKTIVITAS PENGGUNAAN MEDIA MAZE DALAM MENINGKATKAN KECERDASAN VISUAL SPASIAL PADA KELOMPOK A DI PAUD AL IKHSAN PARUNG BOGOR
Authors: Yulianti Puji , Nurulita Nurulita
Published: April 2024

This study aims to use maze media to improve spatial visual intelligence in PAUD Al Ikhsan Parung Bogor. The research method used is survey correlation. The population used in this study was 20 students consisting of 5 boys and 15 girls. Data collection techniques in this study used tests, observations and carried out the teaching and learning process. While the data analysis technique is done by pretest and posttest. Based on the description of the spatial visual intelligence pretest value data above, an average value of 78.3, median 73.5 and mode 80.3 can be obtained. From the 20 respondents it can be seen that there were 2 children who scored between 60-64, there were 2 children who received 65-69, there was 1 child who scored 70-74, there were 3 children who scored 75-79, there were 8 children who scored 80-84 , there is 1 child getting a score of 85-89 and there are 3 children getting a score of 90-94. Based on the results of the description of the Posttest value data for the development of spatial visual intelligence above, it can be obtained an average value of 82, the median is 79, and the mode is 86. From 20 respondents, it can be seen that there are 3 students who score between 63-69, there are 2 students who score between 70-76, there were 5 students who scored between 77-83, there were 7 students who scored between 84-90, and there were 3 students who scored between 91-97
HUBUNGAN ANTARA KEPERCAYAAN DIRI DAN KEMAMPUAN KOMUNIKASI MATEMATIS TENTANG MATERI BANGUN RUANG SISWA KELAS V SD NEGERI SE-KECAMATAN ALIAN
Authors: Agustin Nurlia , Suhartono Suhartono , Salimi Salimi
Published: April 2024

The study aimed to analyze the correlation and contribution self-confidence and mathematical communication skills about solid figures to fifth grade students of public elementary schools in Alian Sub-district in academic year of 2020/202. It was correlational quantitative method. The samples were 289 fifth grade students in 11 public elementary schools throughout the Alian Sub-district. Sampling method was  a cluster random sampling. Data analysis used SPSS application. The results showed that the correlation between self-confidence and mathematical communication skills had correlation coefficient 0.595. The contribution was 35.4%. It concludes that there is positive and significant correlation between self-confidence and mathematical communication skills. It means that the higher student’s self-confidence, the higher student’s mathematical communication skills and vise versa. Self-confidence contributes 35.4% on mathematical communication skills about solid figures and the remaining 64.6% is influenced by other factors
MULTIMEDIA SEBAGAI MEDIA PEMBELAJARAN FIQIH MENGGUNAKAN ADOBE FLASH CS5
Authors: Yusnanto Tri , Mahmudir Moch Ali , Wahyudiono Sugeng
Published: April 2024

Multimedia as a fiqh learning medium at MI Ma'arif Darussolihin Jonggrangan which can increase students' learning interest so as not to quickly feel bored in receiving lessons, to improve student learning achievements as expected, especially in fiqh subjects, considering that the results of student learning achievements are currently not as expected. Namely, the average class is 6.8, while the common value of competency of fiqh subjects that apply today is 7.7. Currently, the approach applied by teachers in fiqh learning still uses a conventional approach. The research method used by researchers is the waterfall model. They are designing a multimedia-based fiqh learning media MI Ma'arif Darussolihin Jonggrangan using the Action Script programming language. Design the system using Adobe Flash CS5 version 9.0 software and graphics processing, using Adobe Photoshop CS5 version 11.0 and Corel Draw X7 software. At the time of all the pretests obtained an average score of 38.95, and students were declared incomplete, while posttests got an average score of 81.4 with a proportion of 92.1% completion with the results of 35 students declared complete while three were declared incomplete. So that it can be said that the application of learning media in the study of fiqh can improve student learning outcomes. The results of this study are a multimedia-based fiqh learning medium that can help solve problems about student achievement results that have not been in line with expectations
PENGGUNAAN MEDIA TORSO UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATERI ORGAN PENCERNAAN DI SD NEGERI BOJONGJENGKOL 03 KABUPATEN BOGOR
Authors: Fajrudin Lili , Rahmat Khoerunnisa Nur Awaliah , Junaedi Yusup
Published: April 2024

This study aims to determine the implementation of the use of learning media using Torso media in improving student learning outcomes in science lessons on the subject of Digestive Organs in Theme 3 Sub-theme 1. The research method used is Kurt Lewin's CAR (Classroom Action Research) with the following steps: (1) planning, (2) action, (3) observation, and (4) reflection. From the results obtained in the pre-cycle learning, it can be seen that only 8 students have completed the KKM with a percentage of 36% with an average value of 62.27. Then proceed to cycle 1 and get a score that only 12 students have completed the KKM with a percentage of 55% with a class average of 67.27. After that, cycle 2 was carried out again with the score that 22 students all completed the KKM with a percentage of 100% with a class average of 90.00. Thus there has been an increasing change so there is no need to take further action because it has been successful. Based on all these data, it can be concluded that using the demonstration method can improve student learning outcomes in Natural Science Subjects Theme 3 Sub-theme 1 in class V SD Negeri Bojongjengkol 03 Ciampea District, Bogor Regency, West Java Province
PERAN MODEL PEMBELAJARAN TUTOR SEBAYA TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS 5 SDN 2 TAHUNAN
Authors: Sutriyani Wulan , Nafila Dwi Rahmatika Riqki , Layliya Putri Syfa’atul
Published: April 2024

This study aims to determine the effect of the Tutor's Learning Method Peer to the mathematics learning outcomes of fifth graders of bar chart material in grade 5 SD N 2 Tahunan. In this study, the type of research used was a descriptive qualitative. Qualitative data analysis techniques were chosen in this study because the data analysis process did not involve or take the form of numbers. The results of the research from observations when it was carried out at SD N 2 Tahunan, several problems were found including, low student learning outcomes, lack of knowledge about the material being taught and weak memorization of multiplication formulas as well as errors in working on questions that occurreddifficulty in applying the formula to solving practice problems
PENGARUH MOTIVASI BELAJAR DENGAN MENGGUNAKAN MODEL KUANTUM TERHADAP HASIL BELAJAR SISWA SEKOLAH DASAR
Authors: Asidiqi Deby Fauzi
Published: April 2024

The  purpose  of  this  study  was  to  determine  the  influence  of  motivation  on learning outcomes of students that using quantum learning model with the direct learning model. The method that used in this research was a quasi experimental with research design nonequivalent control group design.  The  sampling  technique  in  this  research  was  using  cluster random sampling technique. In this research, experiment class using quantum learning model and the control class using direct learning model. The  research  instrument  was  given  in  the  form  of  10  essay  questions.  Data analysis techniques to test the hypothesis were using correlation and linearity (simple  regression).  From  the  calculation  of  the  hypothesis  test  obtained correlation r ≤ +1, 0.9032 ≤ +1, thus there is a significant  functional  relationship  between  the  variables  of  motivation  and learning outcomes of  students who  using  quantum  learning model.  From  the calculation of the linearity hypothesis test (simple regression) obtained Fhitung > Ftabel, 172.68 > 4,09, thus there is a significant functional effect between varaibel motivation and learning outcomes of students who using quantum learning model
PENANAMAN MINAT BACA MELALUI GERAKAN LITERASI SEKOLAH DI SDN SAJIRA 2
Authors: Andriana Encep , Rosidin Odin , Yuliana Rina , Maptuhah Siti Lulu
Published: April 2024

This research was conducted at SDN Sajira 2 based on data of the low interest in reading at Indonesia, especially in SDN Sajira 2 School environment. This study aims to determine the implementation of the school literacy movement in instilling students’ interest at SDN Sajira 2 also to find out about teacher activities in instilling students’ interest in reading through the school literacy movement at SDN Sajira 2. This research was conducted using descriptive qualitative research methods, with descriptive research procedures, data reduction, and selection. The main data in qualitative research are words and he data source comes from primary and secondary data sources, the data collection techniques that the researcher uses are observation, interview, and documentation techniques. The data obtained os then re-examined through data reduction, than presented and concluded, after that, data will be checked for validityusing source triangulation and technical triangulation. The research at this time will describe the cultivation of reading activities for fifteen minutes before studying