bluuebunny/crossref_metadata_2025 huggingface dataset:
Catalytic Hydrogenation of Alkali Lignin Into Bio-Oil via Nano-Lamellar MoSe2-Based Composite Catalysts
Authors: Zhou Xingwang , Zhou Jia , Yu Yongwei , Ma Jiangquan , Sun Xueni , Hu Lanmei
Published: August 2017

In this research, a series of catalysts based on MoSe2 were synthesized by the hydrothermal method and used for the catalytic hydrogenation of alkali lignin for the first time. For 4[Formula: see text]wt.% NiSe2/MoSe2 catalyst, at 290[Formula: see text]C, under 2[Formula: see text]MPa H2 pressure for 1.5[Formula: see text]h, the conversion of alkali lignin and the yield of bio-oil reached 96.47% and 93.68%, respectively. In addition, the composition of the product (bio-oil) was analyzed via Fourier transform infrared (FTIR) spectrometry, gas chromatography-mass spectrometry (GC-MS) spectra, and proton nuclear magnetic resonance (1HNMR) spectra. Finally, our study demonstrated that those MoSe2-based composite catalysts can effectively degrade the biomass into bio-oil containing valuable chemical products.
Influence of Magnetic Anisotropy on Inverse Spin Hall Voltage
Authors: Song M. Y. , Luo G. Y. , Lin J. G. , Samant M. G. , Parkin S. S. P.
Published: August 2017

Spin pumping efficiency (SPE) in a ferromagnetic (FM)/Pt system relies on the effective magnetization damping of FM layer and the interface spin mixing conductance. However, there are very few studies on the influence of magnetic anisotropy of FM material on SPE. In this study, the spin pumping induced spin voltage [Formula: see text] in Fe3O4(58.9[Formula: see text]nm)/Pt(5.5[Formula: see text]nm) is investigated in two different orientations of the external magnetic field, one parallel and other perpendicular to the in-plane easy axis of Fe3O4. The value of [Formula: see text] with the magnetic field along the easy axis is 38% higher compared with that along the hard axis. The possible origin of this enhancement is investigated based on the model of ferromagnetic resonance induced spin pumping.
The Future Promise of Vehicle-to-Grid (V2G) Integration: A Sociotechnical Review and Research Agenda
Authors: Sovacool Benjamin K. , Axsen Jonn , Kempton Willett
Published: August 2017

Vehicle-grid integration (VGI) describes various approaches to link the electric power system and the transportation system in ways that may benefit both. VGI includes systems that treat plug-in electric vehicles (PEVs) as controllable load with a unidirectional flow of electricity, such as “smart” or “controlled” charging or time-of-use (TOU) pricing. VGI typically encompasses vehicle-to-grid (V2G), a more technically advanced vision with bidirectional flow of electricity between the vehicle and power grid, in effect treating the PEV as a storage device. Such VGI systems could help decarbonize transportation, support load balancing, integrate renewable energy into the grid, increase revenues for electricity companies, and create new revenue streams for automobile owners. This review introduces various aspects and visions of VGI based on a comprehensive review. In doing so, it identifies the possible benefits, opportunities, and barriers relating to V2G, according to technical, financial, socio-environmental, and behavioral components. After summarizing our sociotechnical approach and the various opportunities and barriers indicated by existing literature, we construct a proposed research agenda to provide insights into previously understudied and unstudied research objectives. We find that the majority of VGI studies to date focus on technical aspects of VGI, notably on the potential of V2G systems to facilitate load balancing or to minimize electricity costs, in some cases including environmental goals as constraints. Only a few studies directly investigate the role of consumer acceptance and driver behavior within such systems, and barely any studies address the need for institutional capacity and cross-sectoral policy coordination. These gaps create promising opportunities for future research.
Using whiteboards to support college students’ learning of complex physiological concepts
Authors: Inouye Caron Y. , Bae Christine L. , Hayes Kathryn N.
Published: August 2017

Research underscores the importance of retrieval-based practice and application of knowledge for meaningful learning. However, the didactic lecture format continues to persist in traditional university physiology courses. A strategy called whiteboarding, where students use handheld dry erase boards and work in small groups to actively retrieve, discuss, and apply concepts presented in the lecture, has the potential to address challenges associated with actively engaging students in science courses for greater learning. The purpose of this study was to empirically examine the potential benefits of whiteboarding for increasing students’ understanding of animal physiology concepts. Student performance on physiology questions assessing concepts taught using lecture only vs. concepts taught using lecture and whiteboarding were compared within the term that whiteboarding was used, as well as across whiteboard and lecture-only terms taught by the same instructor. Results showed that when whiteboarding was incorporated in the course, student performance on items that assessed concepts corresponding to the whiteboarding activities were significantly higher compared with performance on items that assessed concepts taught through lecture only. These patterns in student performance were found within and across terms. Taken together, findings point to whiteboarding as an effective tool that can be integrated in traditional lecture courses to promote students’ understanding of physiology.
Molecular insights into the normal operation, regulation, and multisystemic roles of K+-Cl− cotransporter 3 (KCC3)
Authors: Garneau A. P. , Marcoux A. A. , Frenette-Cotton R. , Mac-Way F. , Lavoie J. L. , Isenring P.
Published: August 2017

Long before the molecular identity of the Na+-dependent K+-Cl− cotransporters was uncovered in the mid-nineties, a Na+-independent K+-Cl− cotransport system was also known to exist. It was initially observed in sheep and goat red blood cells where it was shown to be ouabain-insensitive and to increase in the presence of N-ethylmaleimide (NEM). After it was established between the early and mid-nineties, the expressed sequence tag (EST) databank was found to include a sequence that was highly homologous to those of the Na+-dependent K+-Cl− cotransporters. This sequence was eventually found to code for the Na+-independent K+-Cl− cotransport function that was described in red blood cells several years before. It was termed KCC1 and led to the discovery of three isoforms called KCC2, KCC3, and KCC4. Since then, it has become obvious that each one of these isoforms exhibits unique patterns of distribution and fulfills distinct physiological roles. Among them, KCC3 has been the subject of great attention in view of its important role in the nervous system and its association with a rare hereditary sensorimotor neuropathy (called Andermann syndrome) that affects many individuals in Quebec province (Canada). It was also found to play important roles in the cardiovascular system, the organ of Corti, and circulating blood cells. As will be seen in this review, however, there are still a number of uncertainties regarding the transport properties, structural organization, and regulation of KCC3. The same is true regarding the mechanisms by which KCC3 accomplishes its numerous functions in animal cells.
Effects of NK1 receptors on gastric motor functions and satiation in healthy humans: results from a controlled trial with the NK1 antagonist aprepitant
Authors: Jacob Deepti , Busciglio Irene , Burton Duane , Halawi Houssam , Oduyebo Ibironke , Rhoten Deborah , Ryks Michael , Harmsen W. Scott , Camilleri Michael
Published: August 2017

Aprepitant, an NK1 receptor antagonist, is approved for the treatment of chemotherapy-induced or postoperative emesis by blocking NK1 receptors in the brain stem vomiting center. The effects of NK1 receptors on gastric functions and postprandial symptoms in humans are unclear; a single, crossover study did not show a significant effect of aprepitant on gastrointestinal transit. Our aim was to compare, in a randomized, double-blind, placebo-controlled, parallel-group study (12 healthy volunteers per group), the effects of aprepitant vs. placebo on gastric emptying of solids (by scintigraphy) with a 320-kcal meal, gastric volumes (GVs; fasting and accommodation by single photon emission-computed tomography ), satiation [maximum tolerated volume (MTV)], and symptoms after a dyspeptogenic meal of Ensure. Aprepitant (125 mg on day 1, followed by 80 mg on days 2–5) or placebo, one tablet daily, was administered for 5 consecutive days. Statistical analysis was by unpaired rank sum test, adjusted for sex difference and body mass index. To assess treatment effects on symptoms, we incorporated MTV in the model. Aprepitant increased fasting, postprandial, and accommodation GV and tended to increase volume to fullness and MTV by ~200 kcal. However, aprepitant increased aggregate symptoms, nausea, and pain scores after ingestion the MTV of Ensure. There was no significant effect of aprepitant on gastric half-emptying time of solids. We conclude that NK1 receptors are involved in the control of GV and in determining postprandial satiation and symptoms. Further studies of the pharmacodynamics and therapeutic role of NK1 receptor antagonists in patients with gastroparesis and dyspepsia are warranted.

NEW & NOTEWORTHY Aprepitant increases fasting, postprandial, and accommodation gastric volumes. Aprepitant increases volume to fullness and maximum tolerated volume during a nutrient drink test. NK1 receptors are involved in the control of gastric volume and in determining postprandial satiation and symptoms.
Filling the void: a role for exercise-induced BDNF and brain amyloid precursor protein processing
Authors: MacPherson Rebecca E. K.
Published: August 2017

Inactivity, obesity, and insulin resistance are significant risk factors for the development of Alzheimer’s disease (AD). Several studies have demonstrated that diet-induced obesity, inactivity, and insulin resistance exacerbate the neuropathological hallmarks of AD. The aggregation of β-amyloid peptides is one of these hallmarks. β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid precursor protein (APP) processing, leading to β-amyloid peptide formation. Understanding how BACE1 content and activity are regulated is essential for establishing therapies aimed at reducing and/or slowing the progression of AD. Exercise training has been proven to reduce the risk of AD as well as decrease β-amyloid production and BACE1 content and/or activity. However, these long-term interventions also result in improvements in adiposity, circulating metabolites, glucose tolerance, and insulin sensitivity making it difficult to determine the direct effects of exercise on brain APP processing. This review highlights this large void in our knowledge and discusses our current understanding of the direct of effect of exercise on β-amyloid production. We have concentrated on the central role that brain-derived neurotrophic factor (BDNF) may play in mediating the direct effects of exercise on reducing brain BACE1 content and activity as well as β-amyloid production. Future studies should aim to generate a greater understanding of how obesity and exercise can directly alter APP processing and AD-related pathologies. This knowledge could provide evidence-based hypotheses for designing therapies to reduce the risk of AD and dementia.
Lower body negative pressure reduces optic nerve sheath diameter during head-down tilt
Authors: Marshall-Goebel Karina , Terlević Robert , Gerlach Darius A. , Kuehn Simone , Mulder Edwin , Rittweger Jörn
Published: August 2017

The microgravity ocular syndrome (MOS) results in significant structural and functional ophthalmic changes during 6-mo spaceflight missions consistent with an increase in cerebrospinal fluid (CSF) pressure compared with the preflight upright position. A ground-based study was performed to assess two of the major hypothesized contributors to MOS, headward fluid shifting and increased ambient CO2, on intracranial and periorbital CSF. In addition, lower body negative pressure (LBNP) was assessed as a countermeasure to headward fluid shifting. Nine healthy male subjects participated in a crossover design study with five head-down tilt (HDT) conditions: −6, −12, and −18° HDT, −12° HDT with −20 mmHg LBNP, and −12° HDT with a 1% CO2 environment, each for 5 h total. A three-dimensional volumetric scan of the cranium and transverse slices of the orbita were collected with MRI, and intracranial CSF volume and optic nerve sheath diameter (ONSD) were measured after 4.5 h HDT. ONSD increased during −6° ( P < 0.001), −12° ( P < 0.001), and −18° HDT ( P < 0.001) and intracranial CSF increased during −12° HDT ( P = 0.01) compared with supine baseline. Notably, LBNP was able to reduce the increases in ONSD and intracranial CSF during HDT. The addition of 1% CO2 during HDT, however, had no further effect on ONSD, but rather ONSD increased from baseline in a similar magnitude to −12° HDT with ambient air ( P = 0.001). These findings demonstrate the ability of LBNP, a technique that targets fluid distribution in the lower limbs, to directly influence CSF and may be a promising countermeasure to help reduce increases in CSF.

NEW & NOTEWORTHY This is the first study to demonstrate the ability of lower body negative pressure to directly influence cerebrospinal fluid surrounding the optic nerve, indicating potential use as a countermeasure for increased cerebrospinal fluid on Earth or in space.
Skeletal muscle signaling, metabolism, and performance during sprint exercise in severe acute hypoxia after the ingestion of antioxidants
Authors: Morales-Alamo David , Guerra Borja , Ponce-González Jesús Gustavo , Guadalupe-Grau Amelia , Santana Alfredo , Martin-Rincon Marcos , Gelabert-Rebato Miriam , Cadefau Joan A. , Cusso Roser , Dorado Cecilia , Calbet José A. L.
Published: August 2017

The aim of this study was to determine if reactive oxygen species (ROS) could play a role in blunting Thr172-AMP-activated protein kinase (AMPK)-α phosphorylation in human skeletal muscle after sprint exercise in hypoxia and to elucidate the potential signaling mechanisms responsible for this response. Nine volunteers performed a single 30-s sprint (Wingate test) in two occasions while breathing hypoxic gas ([Formula: see text] = 75 mmHg): one after the ingestion of placebo and another following the intake of antioxidants (α-lipoic acid, vitamin C, and vitamin E), with a randomized double-blind design. Vastus lateralis muscle biopsies were obtained before, immediately after, and 30- and 120-min postsprint. Compared with the control condition, the ingestion of antioxidants resulted in lower plasma carbonylated proteins, attenuated elevation of the AMP-to-ATP molar ratio, and reduced glycolytic rate ( P < 0.05) without significant effects on performance or V̇o2. The ingestion of antioxidants did not alter the basal muscle signaling. Thr172-AMPKα and Thr184/187-transforming growth factor-β-activated kinase 1 (TAK1) phosphorylation were not increased after the sprint regardless of the ingestion of antioxidants. Thr286-CaMKII phosphorylation was increased after the sprint, but this response was blunted by the antioxidants. Ser485-AMPKα1/Ser491-AMPKα2 phosphorylation increased immediately after the sprints coincident with increased Akt phosphorylation. In summary, antioxidants attenuate the glycolytic response to sprint exercise in severe acute hypoxia and modify the muscle signaling response to exercise. Ser485-AMPKα1/Ser491-AMPKα2 phosphorylation, a known mechanism of Thr172-AMPKα phosphorylation inhibition, is increased immediately after sprint exercise in hypoxia, probably by a mechanism independent of ROS.

NEW & NOTEWORTHY The glycolytic rate is increased during sprint exercise in severe acute hypoxia. This study showed that the ingestion of antioxidants before sprint exercise in severe acute hypoxia reduced the glycolytic rate and attenuated the increases of the AMP-to-ATP and the reduction of the NAD+-to-NADH.H+ ratios. This resulted in a modified muscle signaling response with a blunted Thr286-CaMKII but similar AMP-activated protein kinase phosphorylation responses in the sprints preceded by the ingestion of antioxidants.
Effect of a patent foramen ovale in humans on thermal responses to passive cooling and heating
Authors: Davis James T. , Hay Madeline W. , Hardin Alyssa M. , White Matthew D. , Lovering Andrew T.
Published: August 2017

Humans with a patent foramen ovale (PFO) have a higher esophageal temperature (Tesoph) than humans without a PFO (PFO−). Thus the presence of a PFO might also be associated with differences in thermal responsiveness to passive cooling and heating such as shivering and hyperpnea, respectively. The purpose of this study was to determine whether thermal responses to passive cooling and heating are different between PFO− subjects and subjects with a PFO (PFO+). We hypothesized that compared with PFO− subjects PFO+ subjects would cool down more rapidly and heat up slower and that PFO+ subjects who experienced thermal hyperpnea would have a blunted increase in ventilation. Twenty-seven men (13 PFO+) completed two trials separated by >48 h: 1) 60 min of cold water immersion (19.5 ± 0.9°C) and 2) 30 min of hot water immersion (40.5 ± 0.2°C). PFO+ subjects had a higher Tesoph before and during cold water and hot water immersion ( P < 0.05). However, the rate of temperature change was similar between groups for each condition. Within a subset of 18 subjects (8 PFO+) who experienced thermal hyperpnea, PFO+ subjects experienced thermal hyperpnea at a higher absolute Tesoph but with a blunted magnitude compared with PFO− subjects. These data suggest that PFO+ subjects have a higher Tesoph at rest and have blunted thermal hyperpnea during passive heating.

NEW & NOTEWORTHY Patent foramen ovale (PFO) is found in ~25–40% of the population. The presence of a PFO appears to be associated with a greater core body temperature and blunted ventilatory responses during passive heating. The reason for this blunted ventilatory response to passive heating is unknown but may suggest differences in thermal sensitivity in PFO+ subjects compared with PFO− subjects.
State-dependent sensorimotor gating in a rhythmic motor system
Authors: White Rachel S. , Spencer Robert M. , Nusbaum Michael P. , Blitz Dawn M.
Published: August 2017

Sensory feedback influences motor circuits and/or their projection neuron inputs to adjust ongoing motor activity, but its efficacy varies. Currently, less is known about regulation of sensory feedback onto projection neurons that control downstream motor circuits than about sensory regulation of the motor circuit neurons themselves. In this study, we tested whether sensory feedback onto projection neurons is sensitive only to activation of a motor system, or also to the modulatory state underlying that activation, using the crab Cancer borealis stomatogastric nervous system. We examined how proprioceptor neurons (gastropyloric receptors, GPRs) influence the gastric mill (chewing) circuit neurons and the projection neurons (MCN1, CPN2) that drive the gastric mill rhythm. During gastric mill rhythms triggered by the mechanosensory ventral cardiac neurons (VCNs), GPR was shown previously to influence gastric mill circuit neurons, but its excitation of MCN1/CPN2 was absent. In this study, we tested whether GPR effects on MCN1/CPN2 are also absent during gastric mill rhythms triggered by the peptidergic postoesophageal commissure (POC) neurons. The VCN and POC pathways both trigger lasting MCN1/CPN2 activation, but their distinct influence on circuit feedback to these neurons produces different gastric mill motor patterns. We show that GPR excites MCN1 and CPN2 during the POC-gastric mill rhythm, altering their firing rates and activity patterns. This action changes both phases of the POC-gastric mill rhythm, whereas GPR only alters one phase of the VCN-gastric mill rhythm. Thus sensory feedback to projection neurons can be gated as a function of the modulatory state of an active motor system, not simply switched on/off with the onset of motor activity.

NEW & NOTEWORTHY Sensory feedback influences motor systems (i.e., motor circuits and their projection neuron inputs). However, whether regulation of sensory feedback to these projection neurons is consistent across different versions of the same motor pattern driven by the same motor system was not known. We found that gating of sensory feedback to projection neurons is determined by the modulatory state of the motor system, and not simply by whether the system is active or inactive.
Perception of the dynamic visual vertical during sinusoidal linear motion
Authors: Pomante A. , Selen L. P. J. , Medendorp W. P.
Published: August 2017

The vestibular system provides information for spatial orientation. However, this information is ambiguous: because the otoliths sense the gravitoinertial force, they cannot distinguish gravitational and inertial components. As a consequence, prolonged linear acceleration of the head can be interpreted as tilt, referred to as the somatogravic effect. Previous modeling work suggests that the brain disambiguates the otolith signal according to the rules of Bayesian inference, combining noisy canal cues with the a priori assumption that prolonged linear accelerations are unlikely. Within this modeling framework the noise of the vestibular signals affects the dynamic characteristics of the tilt percept during linear whole-body motion. To test this prediction, we devised a novel paradigm to psychometrically characterize the dynamic visual vertical—as a proxy for the tilt percept—during passive sinusoidal linear motion along the interaural axis (0.33 Hz motion frequency, 1.75 m/s2peak acceleration, 80 cm displacement). While subjects ( n=10) kept fixation on a central body-fixed light, a line was briefly flashed (5 ms) at different phases of the motion, the orientation of which had to be judged relative to gravity. Consistent with the model’s prediction, subjects showed a phase-dependent modulation of the dynamic visual vertical, with a subject-specific phase shift with respect to the imposed acceleration signal. The magnitude of this modulation was smaller than predicted, suggesting a contribution of nonvestibular signals to the dynamic visual vertical. Despite their dampening effect, our findings may point to a link between the noise components in the vestibular system and the characteristics of dynamic visual vertical.

NEW & NOTEWORTHY A fundamental question in neuroscience is how the brain processes vestibular signals to infer the orientation of the body and objects in space. We show that, under sinusoidal linear motion, systematic error patterns appear in the disambiguation of linear acceleration and spatial orientation. We discuss the dynamics of these illusory percepts in terms of a dynamic Bayesian model that combines uncertainty in the vestibular signals with priors based on the natural statistics of head motion.
Extracellular Acid-Base Balance and Ion Transport Between Body Fluid Compartments
Authors: Seifter Julian L. , Chang Hsin-Yun
Published: August 2017

Clinical assessment of acid-base disorders depends on measurements made in the blood, part of the extracellular compartment. Yet much of the metabolic importance of these disorders concerns intracellular events. Intracellular and interstitial compartment acid-base balance is complex and heterogeneous. This review considers the determinants of the extracellular fluid pH related to the ion transport processes at the interface of cells and the interstitial fluid, and between epithelial cells lining the transcellular contents of the gastrointestinal and urinary tracts that open to the external environment. The generation of acid-base disorders and the associated disruption of electrolyte balance are considered in the context of these membrane transporters. This review suggests a process of internal and external balance for pH regulation, similar to that of potassium. The role of secretory gastrointestinal epithelia and renal epithelia with respect to normal pH homeostasis and clinical disorders are considered. Electroneutrality of electrolytes in the ECF is discussed in the context of reciprocal changes in Cl−or non Cl−anions and [Formula: see text].
Characterization of the Aerodynamic Ground Effect and Its Influence in Multirotor Control
Authors: Sanchez-Cuevas Pedro , Heredia Guillermo , Ollero Anibal
Published: August 2017

This paper analyzes the ground effect in multirotors, that is, the change in the thrust generated by the rotors when flying close to the ground due to the interaction of the rotor airflow with the ground surface. This effect is well known in single-rotor helicopters but has been assumed erroneously to be similar for multirotors in many cases in the literature. In this paper, the ground effect for multirotors is characterized with experimental tests in several cases and the partial ground effect, a situation in which one or some of the rotors of the multirotor (but not all) are under the ground effect, is also characterized. The influence of the different cases of ground effect in multirotor control is then studied with several control approaches in simulation and validated with experiments in a test bench and with outdoor flights.
Could Hallucinogens Induce Permanent Pupillary Changes in (Ab)users? A Case Report from New Zealand
Authors: Al-Imam Ahmed
Published: August 2017

An eighteen-year-old female patient of the Caucasian ethnicity from Australasia presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when she is outdoors due to oversensitivity to sunlight. However, her pupillary reaction to light (pupillary light reflex) was intact. The patient is a known user of psychedelic substances (entheogens) including LSD, NBOMe, psilocybin, and DMT. The condition affects both eyes to the same extent. Thorough medical, neurological, and radiological examinations, including an EEG and an MRI of the head and neck region, were completely normal. All these tests failed to detect any pathophysiological or anatomical abnormalities. The patient is a known case of chronic endogenous depression in association with attention deficit hyperactivity disorder, for which she is taking citalopram and Ritalin, respectively. There was neither a family history nor a similar congenital condition in her family.
Research Trend Analysis of Geospatial Information in South Korea Using Text-Mining Technology
Authors: Oh Kwan-Young , Lee Moung-Jin
Published: August 2017

The purpose of this study was to analyze geospatial information (GI) research trends using text-mining techniques. Data were collected from 869 papers found in the Korea Citation Index (KCI) database (DB). Keywords extracted from these papers were classified into 13 GI domains and 13 research domains. We conducted basic statistical analyses (e.g., frequency and time series analyses) and network analyses, using such measures as frequency, degree, closeness centrality, and betweenness centrality, on the resulting domains. We subdivided the most frequent GI domain for more detailed analysis. Such processes permit an analysis of the relationships between the Research Fields associated with each GI. Our time series analysis found that the Climate and Satellite Image domain frequencies continuously increased. Satellite Image, General-Purpose Map, and Natural Disaster Map in the GI domain and Climate and Natural Disaster in the Research Field domain appeared in the center of the GI-Research Field network. We subdivided the Satellite Image domain for detailed analysis. As a result, LANDSAT, KOMPSAT, and MODIS displayed high scores on the frequency, degree, closeness centrality, and betweenness centrality indices. These results will be useful in GI-based interdisciplinary research and the selection of new research themes.
Space-Time Defects and Group Momentum Space
Authors: Arzano Michele , Trześniewski Tomasz
Published: August 2017

We study massive and massless conical defects in Minkowski and de Sitter spaces in various space-time dimensions. The energy momentum of a defect, considered as an (extended) relativistic object, is completely characterized by the holonomy of the connection associated with its space-time metric. The possible holonomies are given by Lorentz group elements, which are rotations and null rotations for massive and massless defects, respectively. In particular, if we fix the direction of propagation of a massless defect in n+1-dimensional Minkowski space, then its space of holonomies is a maximal Abelian subgroup of the AN(n-1) group, which corresponds to the well known momentum space associated with the n-dimensional κ-Minkowski noncommutative space-time and κ-deformed Poincaré algebra. We also conjecture that massless defects in n-dimensional de Sitter space can be analogously characterized by holonomies belonging to the same subgroup. This shows how group-valued momenta related to four-dimensional deformations of relativistic symmetries can arise in the description of motion of space-time defects.
Experimental Validation of Fly-Wheel Passive Launch and On-Orbit Vibration Isolation System by Using a Superelastic SMA Mesh Washer Isolator
Authors: Kwon Seong-Cheol , Jo Mun-Shin , Oh Hyun-Ung
Published: August 2017

On-board appendages with mechanical moving parts for satellites produce undesirable micro-jitters during their on-orbit operation. These micro-jitters may seriously affect the image quality from high-resolution observation satellites. A new application form of a passive vibration isolation system was proposed and investigated using a pseudoelastic SMA mesh washer. This system guarantees vibration isolation performance in a launch environment while effectively isolating the micro-disturbances from the on-orbit operation of jitter source. The main feature of the isolator proposed in this study is the use of a ring-type mesh washer as the main axis to support the micro-jitter source. This feature contrasts with conventional applications of the mesh washers where vibration damping is effective only in the thickness direction of the mesh washer. In this study, the basic characteristics of the SMA mesh washer isolator in each axis were measured in static tests. The effectiveness of the design for the new application form of the SMA mesh washer proposed in this study was demonstrated through both launch environment vibration test at qualification level and micro-jitter measurement test which corresponds to on-orbit condition.
Ginger Ingredients Alleviate Diabetic Prostatic Complications: Effect on Oxidative Stress and Fibrosis
Authors: Eid Basma G. , Mosli Hala , Hasan Atif , El-Bassossy Hany M.
Published: August 2017

Prostatic complications are common in patients with diabetes. This study investigated the effect of different ginger ingredients: zingerone, geraniol, and 6‐gingerol on the prostate in diabetic rats. Diabetes was induced in Wistar rats by streptozotocin intraperitoneal injection (50 mg/kg), and the rats were left for 10 weeks to develop prostatic complications. In diabetic treated groups, rats received daily oral zingerone, geraniol, and 6‐gingerol in doses of 20, 200, and 75 mg/kg, respectively, in the last 8 weeks. Treatment with the compounds caused changes in the ventral prostate of diabetic animals as indicated by the columnar ductal epithelium and dense secretions. There was an amelioration of oxidative stress as evidenced by the lowering of prostate malondialdehyde and elevating prostate oxidized to reduced glutathione (GSH/GSSG) ratios by geraniol and 6‐gingerol. None of the three ginger ingredients affected the hyperglycemia, reduction in body weight gain, and testosterone deficiency seen in diabetic animals. Interleukin‐1β and interleukin‐6 levels remained unchanged. However, zingerone and geraniol ameliorated the fibrosis in diabetic prostate through suppressing the elevated prostate transforming growth factor beta 1 (TGFβ1) and collagen IV. Therefore, ginger ingredients could be beneficial in alleviating diabetic prostatic complications through suppressing oxidative stress and tissue fibrosis.
Inversion Calculation Analysis of Operational Tunnel Structure Based on the Distributed Optical-Fiber Sensing System
Authors: Zhao Jie , Feng Jiang , Ren Liang
Published: August 2017

In combination of the actual project in Dalian Baiyun Mountain Tunnel, this paper introduces the principle of fiber optic sensor monitoring system based on optical time domain reflectometer. Then, based on the orthogonal design and even design scheme, this paper carries out a numerical experiment on the tunnel surrounding rock and establishes a regression model of the mapping relation between surrounding rock parameters of operation tunnel and the monitored displacement in order to set the difference between the monitored displacement and the calculated displacement as the fitness function. In the end, this paper carries out parameter identification based on the differential evolution algorithm. Achievements of the study proved that real-time safety warning could be realized inside the tunnel by monitoring the deformation parameters of tunnel vault at real time relying on the optical-fiber sensing system of the optical time domain reflectometer (OTDR). Parameters identification was carried out on the structure with differential evolution according to measured data and selected parameters, and great coincidence was obtained between the measured displacement and the identified parameters displacement, which proved the strong adaptability of the method.
Strengths and Failure Characteristics of Self-Compacting Concrete Containing Recycled Waste Glass Aggregate
Authors: AL-Bawi Rahman Khaleel , Kadhim Ihsan Taha , AL-Kerttani Osamah
Published: August 2017

The effects of different proportions of green-colored waste glass (WG) cullet on the mechanical and fracture properties of self-compacting concrete (SCC) were experimentally investigated. Waste bottles were collected, washed, crushed, and sieved to prepare the cullet used in this study. Cullet was incorporated at different percentages (0%, 20%, 40%, 60%, 80%, and 100% by weight) instead of natural fine aggregate (NFA) and/or natural coarse aggregate (NCA). Three SCC series were designed with a constant slump flow of700±30 mm, total binder content of 570 kg/m3and at water-to-binder (w/b) ratio of 0.35. Moreover, fly ash (FA) was used in concrete mixtures at 20% of total binder content. Mechanical aspects such as compressive, splitting tensile, and net flexural strengths and modulus of elasticity of SCC were investigated and experimentally computed at 28 days of age. Moreover, failure characteristics of the concretes were also monitored via three-point bending test on the notched beams. The findings revealed that the mechanical properties as well as fracture parameters were adversely influenced by incorporating of WG cullet. However, highest reduction of compressive strength did not exceed 43% recorded at 100% WG replacement level. Concretes containing WG showed less brittle behavior than reference concrete at any content.
Multiobjective Optimization for Fixture Locating Layout of Sheet Metal Part Using SVR and NSGA‐II
Authors: Yang Yuan , Wang Zhongqi , Yang Bo , Jing Zewang , Kang Yonggang
Published: August 2017

Fixture plays a significant role in determining the sheet metal part (SMP) spatial position and restraining its excessive deformation in many manufacturing operations. However, it is still a difficult task to design and optimize SMP fixture locating layout at present because there exist multiple conflicting objectives and excessive computational cost of finite element analysis (FEA) during the optimization process. To this end, a new multiobjective optimization method for SMP fixture locating layout is proposed in this paper based on the support vector regression (SVR) surrogate model and the elitist nondominated sorting genetic algorithm (NSGA‐II). By using ABAQUS™ Python script interface, a parametric FEA model is established. And the fixture locating layout is treated as design variables, while the overall deformation and maximum deformation of SMP under external forces are as the multiple objective functions. First, a limited number of training and testing samples are generated by combining Latin hypercube design (LHD) with FEA. Second, two SVR prediction models corresponding to the multiple objectives are established by learning from the limited training samples and are integrated as the multiobjective optimization surrogate model. Third, NSGA‐II is applied to determine the Pareto optimal solutions of SMP fixture locating layout. Finally, a multiobjective optimization for fixture locating layout of an aircraft fuselage skin case is conducted to illustrate and verify the proposed method.
HIV Epidemic in Tanzania: The Possible Role of the Key Populations
Authors: Mpondo Bonaventura C. T. , Gunda Daniel W. , Kilonzo Semvua B.
Published: August 2017

HIV remains a public health concern in Tanzania and other Eastern and Southern African countries. Estimates show that there were about 1.4 million people living with HIV in Tanzania in the year 2013. HIV is a generalized epidemic in Tanzania with heterosexual transmission being the main route of transmission. Recently, however, there has been growing concern on the potential role of the key populations in HIV epidemic in the country. Studies done have shown significantly higher HIV prevalence in these populations compared to the general population. These studies have also reported high risky behaviors among members of these populations. This review aims at discussing the possible role of the key populations in the HIV epidemic in Tanzania.
A Low Profile Ultrawide Band Monopole Antenna for Wearable Applications
Authors: Doddipalli Srinivas , Kothari Ashwin , Peshwe Paritosh
Published: August 2017

A low profile pentagonal shaped monopole antenna is designed and presented for wearable applications. The main objective of this paper is to design a miniaturized ultrawide band monopole planar antenna which can work efficiently in free space but also on the surface of the human body. The impact of human tissues on antenna performance is explained using the proposed pentagonal monopole antenna. The antenna is designed with a pentagonal radiator and a matched feed line of 50 ohm and square slots are integrated on defected ground of FR4 substrate with a size of 15 mm × 25 mm to achieve ultrawide band (UWB) performance in free space and human proximity. This overall design will enhance the antenna performance with wide bandwidth ranging from 2.9 GHz to 11 GHz. Specific absorption rate (SAR) of the proposed antenna on dispersive phantom model is also measured to observe the exposure of electromagnetic energy on human tissues. The simulated and measured results of the proposed antenna exhibit wide bandwidth and radiation characteristics in both free space and human proximity.
Determination of Different Saccharides Concentration by Means of a Multienzymes Amperometric Biosensor
Authors: Portaccio Marianna , Lepore Maria
Published: August 2017

A three-electrode amperometric biosensor for the detection of two different saccharides (lactose and glucose) in aqueous solutions is described. On the graphite working electrode, the glucose oxidase (GOD) andβ-galactosidase (β-gal) were coimmobilized by means of covalent bonding. The response of the biosensor as a function of the relative concentration of the two immobilized enzymes was investigated and the best working conditions were identified by measuring the sensitivity and the linear range response. In particular, our best lactose biosensor shows a linear range up to 0.010 mM and a limit of detection (LOD) and a sensitivity equal to 0.001 mM and 850 ± 81 μA/mM, respectively. For glucose, the values of the above-mentioned parameters are equal to 0.015 mM for the linear range, 0.001 mM for LOD, and 505 ± 55 μA/mM for the sensitivity. The working parameters of our biosensors are significant in comparison with other biosensors developed for concentration determination of the two saccharides investigated in the present work. In particular, low (LOD) and high sensitivities are obtained for lactose and glucose. To challenge our biosensor with real samples, it was tested using fruit juices, skim milk, and whey.
Component Importance Measure Computation Method Based Fuzzy Integral with Its Application
Authors: Lin Shuai , Wang Yanhui , Jia Limin , Li Yang
Published: August 2017

In view of the negative impact of component importance measures based on system reliability theory and centrality measures based on complex networks theory, there is an attempt to provide improved centrality measures (ICMs) construction method with fuzzy integral for measuring the importance of components in electromechanical systems in this paper. ICMs are the meaningful extension of centrality measures and component importance measures, which consider influences on function and topology between components to increase importance measures usefulness. Our work makes two important contributions. First, we propose a novel integration method of component importance measures to define ICMs based on Choquet integral. Second, a meaningful fuzzy integral is first brought into the construction comprehensive measure by fusion multi-ICMs and then identification of important components which could give consideration to the function of components and topological structure of the whole system. In addition, the construction method of ICMs and comprehensive measure by integration multi-CIMs based on fuzzy integral are illustrated with a holistic topological network of bogie system that consists of 35 components.
Mean First Passage Time of Preferential Random Walks on Complex Networks with Applications
Authors: Zheng Zhongtuan , Xiao Gaoxi , Wang Guoqiang , Zhang Guanglin , Jiang Kaizhong
Published: August 2017

This paper investigates, both theoretically and numerically, preferential random walks (PRW) on weighted complex networks. By using two different analytical methods, two exact expressions are derived for the mean first passage time (MFPT) between two nodes. On one hand, the MFPT is got explicitly in terms of the eigenvalues and eigenvectors of a matrix associated with the transition matrix of PRW. On the other hand, the center‐product‐degree (CPD) is introduced as one measure of node strength and it plays a main role in determining the scaling of the MFPT for the PRW. Comparative studies are also performed on PRW and simple random walks (SRW). Numerical simulations of random walks on paradigmatic network models confirm analytical predictions and deepen discussions in different aspects. The work may provide a comprehensive approach for exploring random walks on complex networks, especially biased random walks, which may also help to better understand and tackle some practical problems such as search and routing on networks.
Synchronization of Two Fractional-Order Chaotic Systems via Nonsingular Terminal Fuzzy Sliding Mode Control
Authors: Song Xiaona , Song Shuai , Balsera Ines Tejado , Liu Leipo , Zhang Lei
Published: August 2017

The synchronization of two fractional-order complex chaotic systems is discussed in this paper. The parameter uncertainty and external disturbance are included in the system model, and the synchronization of the considered chaotic systems is implemented based on the finite-time concept. First, a novel fractional-order nonsingular terminal sliding surface which is suitable for the considered fractional-order systems is proposed. It is proven that once the state trajectories of the system reach the proposed sliding surface they will converge to the origin within a given finite time. Second, in terms of the established nonsingular terminal sliding surface, combining the fuzzy control and the sliding mode control schemes, a novel robust single fuzzy sliding mode control law is introduced, which can force the closed-loop dynamic error system trajectories to reach the sliding surface over a finite time. Finally, using the fractional Lyapunov stability theorem, the stability of the proposed method is proven. The proposed method is implemented for synchronization of two fractional-order Genesio-Tesi chaotic systems with uncertain parameters and external disturbances to verify the effectiveness of the proposed fractional-order nonsingular terminal fuzzy sliding mode controller.
Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms
Authors: Olmez Inan , Brenneman Breanna , Xiao Aizhen , Serbulea Vlad , Benamar Mouadh , Zhang Ying , Manigat Laryssa , Abbas Tarek , Lee Jeongwu , Nakano Ichiro , Godlewski Jakub , Bronisz Agnieszka , Abounader Roger , Leitinger Norbert , Purow Benjamin
Published: August 2017

Purpose: Glioblastoma (GBM) is a deadly brain tumor marked by dysregulated signaling and aberrant cell-cycle control. Molecular analyses have identified that the CDK4/6-Rb-E2F axis is dysregulated in about 80% of GBMs. Single-agent CDK4/6 inhibitors have failed to provide durable responses in GBM, suggesting a need to combine them with other agents. We investigate the efficacy of the combination of CDK4/6 inhibition and mTOR inhibition against GBM.

Experimental Design: Preclinical in vitro and in vivo assays using primary GBM cell lines were performed.

Results: We show that the CDK4/6 inhibitor palbociclib suppresses the activity of downstream mediators of the mTOR pathway, leading to rebound mTOR activation that can be blocked by the mTOR inhibitor everolimus. We further show that mTOR inhibition with everolimus leads to activation of the Ras mediator Erk that is reversible with palbociclib. The combined treatment strongly disrupts GBM metabolism, resulting in significant apoptosis. Further increasing the utility of the combination for brain cancers, everolimus significantly increases the brain concentration of palbociclib.

Conclusions: Our findings demonstrate that the combination of CDK4/6 and mTOR inhibition has therapeutic potential against GBM and suggest it should be evaluated in a clinical trial. Clin Cancer Res; 23(22); 6958–68. ©2017 AACR.
Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis
Authors: Secchin Pedro , Trope Beatriz Moritz , Fernandes Larissa Araujo , Barreiros Glória , Ramos-e-Silva Marcia
Published: August 2017

Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. We present a 61-year-old man who, after an insect bite in the left leg, developed an ulcerated lesion associated with ascending lymphangitis, nonresponsive to previous antibiotic therapies. The patient was admitted for investigation, based on the main diagnostic hypothesis of lymphatic cutaneous sporotrichosis entailed by the highly suggestive morphology, associated with the epidemiologic information that he is a resident of the city of Rio de Janeiro. While culture results were being awaited, the patient was medicated with sulfamethoxazole-trimethoprim to cover CA-MRSA and evolved with total healing of the lesions. After hospital discharge, using an ulcer fragment, an Actinomyces sp. was cultivated and N. brasiliensis was identified by molecular biology. The objective of this report is to demonstrate a case of lymphocutaneous nocardiosis caused by N. brasiliensis after a probable insect bite. Despite the patient being a resident of the State of Rio de Janeiro (endemic region for sporotrichosis), it is highlighted that it is necessary to be aware of the differential diagnoses of an ulcerated lesion with lymphangitis, favoring an early diagnosis and appropriate treatment of the illness.