bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospective Analysis of the Ventilatory Workload Kinetic Index during Stability and Crisis in Patients with Asthma and COPD in a Monitored Program
Authors: Muñoz-Cofré Rodrigo , Pinochet-Urzúa Ramón , del Sol Mariano , Medina-González Paul , Valenzuela-Vásquez Jorge , Molina-Vergara Gerardo , Lizama-Pérez Rodrigo , Escobar-Cabello Máximo
Published: March 2024

To assess ventilatory evolution through the Ventilatory Workload Kinetic Index (VWKI) in patients with asthma and chronic obstructive pulmonary disease (COPD) during stability and exacerbation. Retrospective analysis. Conducted at the Padre Alberto Hurtado Hospital, Santiago, Chile. Ten patients with asthma and fifty-five with COPD participated. Sixty-five clinical records were reviewed. The VWKI in stability and exacerbation of these patients was extracted. When analyzing the baseline with the peak in both asthma and COPD, there was a significant increase in the VWKI. Similarly, the loads, translations, and supports significantly increased from the baseline to the peak. However, in the loads, there were no changes in airway resistance for asthma or in cough for COPD. Likewise, the supports for asthma and COPD showed no changes in the O2. The VWKI determined ventilatory issues in outpatients and made locating the greatest compromise in loads, translations, or supports possible.
Conservation Humanities and Multispecies Justice
Authors: Heise Ursula K.
Published: March 2024

This article argues that biodiversity conservation is primarily a social and cultural issue and only secondarily a scientific one. It explains the proxy logic of narratives about endangered species, which typically serve as proxies for community identities and the changes communities have undergone through processes of modernization and colonization. Polar bears, whose endangerment is interpreted differently by North American and European audiences, on the one hand, and by Inuit communities, on the other, serve as an example of how endangered species narratives not only involve culture but also, more specifically, issues of multispecies justice. Conservation humanities needs to engage with the two central problems that multispecies justice has identified and grappled with: conflicts between the interests of disadvantaged human communities and nonhuman species and conflicts and trade-offs between the interests of different nonhuman species. The essay argues that adopting the framework of “multispecies justice” rather than “conservation” will help to overcome some of the impasses of interdisciplinary collaboration in environmental studies in the past.
Effects of Continuous Glucose Monitoring on Glycemic Control in Type 2 Diabetes: A Systematic Review and Meta-Analysis
Authors: Kong Seung-Yeon , Cho Mi-Kyoung
Published: March 2024

As the prevalence of diabetes is rapidly increasing, the use of continuous glucose monitoring, which is effective in improving glycemic control in type 2 diabetes, is increasing. Methods: Systematic review was performed according to PRISMA criteria. The search was conducted for articles published until 31 May 2023 in PubMed, CINAHL, Cochrane Library, EMBASE, ClinicalKey, etc. The meta-analysis involved the synthesis of effect size; tests of homogeneity and heterogeneity; trim and fill plot; Egger’s regression test; and Begg’s test for assessing publication bias. Results: 491 studies were searched, of which 17 studies that met the selection criteria were analyzed. The overall effect on HbA1c was −0.37 (95% CI, −0.63~−0.11, p < 0.001), with HbA1c decreasing significantly after CGM interventions. Sub-analyses showed that the study was statistically significant in those aged 60 years or older, when rt-CGM was used and when the study was performed in multiple centers. Conclusion: The results of this study showed that intervention using CGM was effective in reducing HbA1c in type 2 diabetes. The factors identified in this study can be used as guidelines for developing future CGM intervention programs.
Assessment of Intuitive Eating and Mindful Eating among Higher Education Students: A Systematic Review
Authors: Rezende Fabiane , Oliveira Bruno M. P. M. , Poínhos Rui
Published: March 2024

Background: The role of mindful eating (ME) and intuitive eating (IE) in improving eating behavior, diet quality, and health is an area of increasing interest. Objective: The objective of this review was to identify the instruments used to assess ME and IE among higher education students and outcomes related to these dimensions. Methods: This review was carried out according to the PRISMA statement, through systematic searches in PubMed, Web of Science, PsycInfo, and Scopus. The inclusion criteria selected for higher education students, levels of ME and/or IE reported, and observational and clinical studies. The exclusion criteria selected against reviews, qualitative studies, and case studies. Quality was assessed using the Academy of Nutrition and Dietetics Quality Criteria Checklist. Results: A total of 516 initial records were identified, from which 75 were included. Cross-sectional studies were the most common research design (86.7%). Most studies were conducted with samples that were predominantly female (90.7%), White (76.0%), aged 18 to 22 years (88.4%), with BMI < 25 kg/m2 (83.0%), and in the United States (61.3%). The Intuitive Eating Scale (IES), the Mindful Eating Questionnaire (MEQ), and their different versions were the most used instruments. The outcomes most studies included were eating behavior and disorders (77.3%), anthropometric assessments (47.8%), mental health (42.0%), and body image (40.6%). Regarding the quality of studies, 34.7% of studies were assigned a positive, 1.3% a negative, and 64.0% a neutral rate. Conclusions: IES and MEQ were the most used instruments. RCT and cohort studies are scarce, and future research with a higher level of quality is needed, especially on the topics of food consumption, diet quality, and biochemical markers.
Association between Post-Hospitalization Psychological Distress, Exercise Capacity, Physical Function and Health Status in COVID-19 Survivors
Authors: D’Ors-Vilardebó Clara , Cebrià i Iranzo Maria Àngels , González-King-Garibotti Carola , Vázquez-Arce María Isabel , Calvache-Mateo Andrés , López-López Laura , Valenza Marie Carmen
Published: March 2024

This study aims to determine whether post-hospitalization psychological distress is associated with exercise capacity, physical function and health status in COVID-19 survivors. In this observational study, hospitalized COVID patients were included and divided into two groups according to the mental component summary subscale of the 12-item Short-Form Health Survey. Patients with a score ≤ 45 were included in the psychological distress group, and patients with a score > 45 were included in the non-psychological distress group. The main variables were exercise capacity, physical function, and health status. Patients were evaluated at discharge, 3 months, and at 6 months follow-up. Finally, a total of 60 patients were included in the study. Significant differences were found in exercise capacity, physical function, and health status (p < 0.05), with worse results in the group with psychological distress at discharge and 3 months follow-up. At 6 months after discharge, COVID patients with psychological distress exhibited worse results in exercise capacity, physical function, and health status, being significant exercise capacity and physical function (p < 0.05). It can be concluded that COVID patients with psychological distress at hospital discharge reported worse exercise capacity, physical function and health status at hospital discharge, 3 months and 6 months follow-up.
An Archaeometric Analysis of Black-Appearing Iron Age Glass Beads from Vinha das Caliças 4 (Portugal)
Authors: Lončarić Valentina , Arruda Ana Margarida , Barrulas Pedro , Costa Mafalda
Published: March 2024

Phoenician colonisation of the Iberian Peninsula in the 1st millennium BCE introduced many novel and luxurious goods to the local populations of the Western Mediterranean. Among them, black-appearing glass beads are characteristic of indigenous female burials in Southern Portugal during the 6th century BCE. This study presents the results of the first comprehensive archaeometric investigation of black-appearing glass from Vinha das Caliças 4 (Portugal), and of black-appearing glass from the Iberian Peninsula in general. A multi-analytical approach employing Stereomicroscopic observation of manufacture and use traces, VP-SEM-EDS, μ-XRD, and LA-ICP-MS was used to cover a wide range of questions regarding technology and provenance. All analysed samples are natron glass. All samples of black and white beads are characterized by high Zr and low Sr values typically ascribed to the use of Egyptian sands. A comparison of the results of previous studies from the same site clearly demonstrates at least two geochemical provenances for Phoenician-traded glass beads, located in the Levantine region and Egypt, respectively. Furthermore, different colours of glass in individual polychrome beads exhibit similar trace element patterns, which might suggest these beads could have been produced close to glassmaking sites/regions.
Characterisation and Expression of Osteogenic and Periodontal Markers of Bone Marrow Mesenchymal Stem Cells (BM-MSCs) from Diabetic Knee Joints
Authors: Hussein Nancy , Meade Josephine , Pandit Hemant , Jones Elena , El-Gendy Reem
Published: March 2024

Type 2 diabetes mellitus (T2DM) represents a significant health problem globally and is linked to a number of complications such as cardiovascular disease, bone fragility and periodontitis. Autologous bone marrow mesenchymal stem cells (BM-MSCs) are a promising therapeutic approach for bone and periodontal regeneration; however, the effect of T2DM on the expression of osteogenic and periodontal markers in BM-MSCs is not fully established. Furthermore, the effect of the presence of comorbidities such as diabetes and osteoarthritis on BM-MSCs is also yet to be investigated. In the present study, BM-MSCs were isolated from osteoarthritic knee joints of diabetic and nondiabetic donors. Both cell groups were compared for their clonogenicity, proliferation rates, MSC enumeration and expression of surface markers. Formation of calcified deposits and expression of osteogenic and periodontal markers were assessed after 1, 2 and 3 weeks of basal and osteogenic culture. Diabetic and nondiabetic BM-MSCs showed similar clonogenic and growth potentials along with comparable numbers of MSCs. However, diabetic BM-MSCs displayed lower expression of periostin (POSTN) and cementum protein 1 (CEMP-1) at Wk3 osteogenic and Wk1 basal cultures, respectively. BM-MSCs from T2DM patients might be suitable candidates for stem cell-based therapeutics. However, further investigations into these cells’ behaviours in vitro and in vivo under inflammatory environments and hyperglycaemic conditions are still required.
Rapid and Convenient Single-Chain Variable Fragment-Employed Electrochemical C-Reactive Protein Detection System
Authors: Miura Daimei , Motohashi Saki , Goto Ayaka , Kimura Hayato , Tsugawa Wakako , Sode Koji , Ikebukuro Kazunori , Asano Ryutaro
Published: March 2024

Although IgG-free immunosensors are in high demand owing to ethical concerns, the development of convenient immunosensors that alternatively integrate recombinantly produced antibody fragments, such as single-chain variable fragments (scFvs), remains challenging. The low affinity of antibody fragments, unlike IgG, caused by monovalent binding to targets often leads to decreased sensitivity. We improved the affinity owing to the bivalent effect by fabricating a bivalent antibody–enzyme complex (AEC) composed of two scFvs and a single glucose dehydrogenase, and developed a rapid and convenient scFv-employed electrochemical detection system for the C-reactive protein (CRP), which is a homopentameric protein biomarker of systemic inflammation. The development of a point-of-care testing (POCT) system is highly desirable; however, no scFv-based CRP-POCT immunosensors have been developed. As expected, the bivalent AEC showed higher affinity than the single scFv and contributed to the high sensitivity of CRP detection. The electrochemical CRP detection using scFv-immobilized magnetic beads and the bivalent AEC as capture and detection antibodies, respectively, was achieved in 20 min without washing steps in human serum and the linear range was 1–10 nM with the limit of detection of 2.9 nM, which has potential to meet the criteria required for POCT application in rapidity, convenience, and hand-held detection devices without employing IgGs.
Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(N-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels
Authors: Liu Xiaohong , Shen Juanli , Wang Ying , Li Ming , Fu Shiyu
Published: March 2024

Photoinduced metal-free ATRP has been successfully applied to fabricate thermo-responsive cellulose graft copolymer (PNIPAM-g-Cell) using 2-bromoisobuturyl bromide-modified cellulose as the macroinitiator. The polymerization of N-isopropylacrylamide (NIPAM) from cellulose was efficiently activated and deactivated with UV irradiation in the presence of an organic-based photo-redox catalyst. Both FTIR and 13C NMR analysis confirmed the structural similarity between the obtained PNIPAM-g-Cell and that synthesized via traditional ATRP methods. When the concentration of the PNIPAM-g-Cell is over 5% in water, it forms an injectable thermos-responsive hydrogel composed of micelles at 37 °C. Since organic photocatalysis is a metal-free ATRP, it overcomes the challenge of transition-metal catalysts remaining in polymer products, making this cellulose-based graft copolymer suitable for biomedical applications. In vitro release studies demonstrated that the hydrogel can continuously release DOX for up to 10 days, and its cytotoxicity indicates that it is highly biocompatible. Based on these findings, this cellulose-based injectable, thermo-responsive drug-loaded hydrogel is suitable for intelligent drug delivery systems.
From Case Reports to Molecular Insight: Examining the Outcomes and Underlying Mechanisms of Squamous Cell Carcinoma in Breast Implant Patients—A Systematic Review
Authors: Camicia Alexandra , Foppiani Jose A. , Raska Otakar , Hernandez Alvarez Angelica , Lee Daniela , Taritsa Iulianna C. , Schuster Kirsten A. , Wan Rou , Neradová Sylva , Lin Gavin J. , Lee Theodore C. , Molitor Martin , Zikan Michal , Lin Samuel J.
Published: March 2024

There is extensive coverage in the existing literature on implant-associated lymphomas like anaplastic large-cell lymphoma, but breast implant-associated squamous cell carcinoma (BIA-SCC) has received limited scholarly attention since its first case in 1992. Thus, this study aims to conduct a qualitative synthesis focused on the underexplored association between breast implants and BIA-SCC. A systematic review was conducted utilizing the PubMed, Web of Science, and Cochrane databases to identify all currently reported cases of BIA-SCC. Additionally, a literature review was performed to identify potential biochemical mechanisms that could lead to BIA-SCC. Studies were vetted for quality using the NIH quality assessment tool. From an initial pool of 246 papers, 11 met the quality criteria for inclusion, examining a total of 14 patients aged between 40 and 81 years. BIA-SCC was found in a diverse range of implants, including those with smooth and textured surfaces, as well as those filled with saline and silicone. The condition notably manifested a proclivity for aggressive clinical progression, as evidenced by a mortality rate approximating 21.4% within a post-diagnostic interval of six months. Our literature review reveals that chronic inflammation, driven by various external factors such as pathogens and implants, can initiate carcinogenesis through epigenetic modifications and immune system alterations. This includes effects from exosomes and macrophage polarization, showcasing potential pathways for the pathogenesis of BIA-SCC. The study highlights the pressing need for further investigation into BIA-SCC, a subject hitherto inadequately addressed in the academic sphere. This necessitates the urgency for early screening and intervention to improve postoperative outcomes. While the review is confined by its reliance on case reports and series, it serves as a valuable reference for future research endeavors.
Dualistic Effects of PRKAR1A as a Potential Anticancer Target in Cancer Cells and Cancer-Derived Stem Cells
Authors: Baek Joong-Won , Nam A-Reum , Kim Kyunggon , Kim Pyung-Hwan
Published: March 2024

The integration of innovative medical technologies and interdisciplinary collaboration could improve the treatment of cancer, a globally prevalent and often deadly disease. Despite recent advancements, current cancer therapies fail to specifically address recurrence and target cancer stem cells (CSCs), which contribute to relapse. In this study, we utilized three types of cancer cells, from which three types of CSCs were further derived, to conduct a proteomic analysis. Additionally, shared cell surface biomarkers were identified as potential targets for a comprehensive treatment strategy. The selected biomarkers were evaluated through short hairpin RNA treatment, which revealed contrasting functions in cancer cells and CSCs. Knockdown of the identified proteins revealed that they regulate the epithelial–mesenchymal transition (EMT) and stemness via the ERK signaling pathway. Resistance to anticancer agents was consequently reduced, ultimately enhancing the overall anticancer effects of the treatment. Additionally, the significance of these biomarkers in clinical patient outcomes was confirmed using bioinformatics. Our study suggests a novel cancer treatment strategy that addresses the limitations of current anticancer therapies.
O26 Polysaccharides as Key Players in Enteropathogenic E. coli Immune Evasion and Vaccine Development
Authors: Lemos Thiago Jordão da Silva , Silva Herbert Guimarães de Sousa , Previato José Osvaldo , Mendonça-Previato Lucia , Freitas Elisangela Oliveira de , Barbosa Angela Silva , Franzolin Marcia Regina , Santos Luis Fernando dos , Melo Bruna de Sousa , Anjos Geovana Ferreira dos , Gonçalves Renata Hiromi Nakagima , Domingos Marta de Oliveira
Published: March 2024

Enteropathogenic Escherichia coli (EPEC) produce a capsule of polysaccharides identical to those composing the O-antigen polysaccharide of its LPS (lipopolysaccharide) molecules. In light of this, the impact of O26 polysaccharides on the immune evasion mechanisms of capsulated O26 EPEC compared to non-capsulated enterohemorrhagic Escherichia coli (EHEC) was investigated. Our findings reveal that there was no significant difference between the levels in EPEC and EHEC of rhamnose (2.8:2.5), a molecule considered to be a PAMP (Pathogen Associated Molecular Patterns). However, the levels of glucose (10:1.69), heptose (3.6:0.89) and N-acetylglucosamine (4.5:2.10), were significantly higher in EPEC than EHEC, respectively. It was also observed that the presence of a capsule in EPEC inhibited the deposition of C3b on the bacterial surface and protected the pathogen against lysis by the complement system. In addition, the presence of a capsule also protected EPEC against phagocytosis by macrophages. However, the immune evasion provided by the capsule was overcome in the presence of anti-O26 polysaccharide antibodies, and additionally, these antibodies were able to inhibit O26 EPEC adhesion to human epithelial cells. Finally, the results indicate that O26 polysaccharides can generate an effective humoral immune response, making them promising antigens for the development of a vaccine against capsulated O26 E. coli.
A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic
Authors: Goryunov Kirill , Ivanov Mikhail , Kulikov Andrey , Shevtsova Yulia , Burov Artem , Podurovskaya Yulia , Zubkov Victor , Degtyarev Dmitry , Sukhikh Gennady , Silachev Denis
Published: March 2024

Neonatal disorders, particularly those resulting from prematurity, pose a major challenge in health care and have a significant impact on infant mortality and long-term child health. The limitations of current therapeutic strategies emphasize the need for innovative treatments. New cell-free technologies utilizing extracellular vesicles (EVs) offer a compelling opportunity for neonatal therapy by harnessing the inherent regenerative capabilities of EVs. These nanoscale particles, secreted by a variety of organisms including animals, bacteria, fungi and plants, contain a repertoire of bioactive molecules with therapeutic potential. This review aims to provide a comprehensive assessment of the therapeutic effects of EVs and mechanistic insights into EVs from stem cells, biological fluids and non-animal sources, with a focus on common neonatal conditions such as hypoxic–ischemic encephalopathy, respiratory distress syndrome, bronchopulmonary dysplasia and necrotizing enterocolitis. This review summarizes evidence for the therapeutic potential of EVs, analyzes evidence of their mechanisms of action and discusses the challenges associated with the implementation of EV-based therapies in neonatal clinical practice.
Li3V2(PO4)3 Cathode Material: Synthesis Method, High Lithium Diffusion Coefficient and Magnetic Inhomogeneity
Authors: Gavrilova Tatiana , Deeva Yulia , Uporova Anastasiya , Chupakhina Tatiana , Yatsyk Ivan , Rogov Alexey , Cherosov Mikhail , Batulin Ruslan , Khrizanforov Mikhail , Khantimerov Sergey
Published: March 2024

Li3V2(PO4)3 cathodes for Li-ion batteries (LIBs) were synthesized using a hydrothermal method with the subsequent annealing in an argon atmosphere to achieve optimal properties. The X-ray diffraction analysis confirmed the material’s single-phase nature, while the scanning electron microscopy revealed a granular structure, indicating a uniform particle size distribution, beneficial for electrochemical performance. Magnetometry and electron spin resonance studies were conducted to investigate the magnetic properties, confirming the presence of the relatively low concentration and highly uniform distribution of tetravalent vanadium ions (V4+), which indicated low lithium deficiency values in the original structure and a high degree of magnetic homogeneity in the sample, an essential factor for consistent electrochemical behavior. For this pure phase Li3V2(PO4)3 sample, devoid of any impurities such as carbon or salts, extensive electrochemical property testing was performed. These tests resulted in the experimental discovery of a remarkably high lithium diffusion coefficient D = 1.07 × 10−10 cm2/s, indicating excellent ionic conductivity, and demonstrated impressive stability of the material with sustained performance over 1000 charge–discharge cycles. Additionally, relithiated Li3V2(PO4)3 (after multiple electrochemical cycling) samples were investigated using scanning electron microscopy, magnetometry and electron spin resonance methods to determine the extent of degradation. The combination of high lithium diffusion coefficients, a low degradation rate and remarkable cycling stability positions this Li3V2(PO4)3 material as a promising candidate for advanced energy storage applications.
Numerical and Experimental Investigations on the Acoustic Characteristics of a Single-Stage Centrifugal Pump
Authors: Lehr Christian , Munsch Pascal , Skoda Romuald , Brümmer Andreas
Published: March 2024

The acoustic properties of a single-stage centrifugal pump with low specific speed are investigated by means of compressible 3D CFD simulations (URANS) and experiments. In order to determine the pump’s acoustic transmission and excitation characteristics, a four-pole approach in the frequency domain is used. The transmission parameters determined by simulation are compared to experiments in water and air as functions of the Helmholtz number. The results indicate that the acoustic transmission characteristics within the experiments are significantly influenced by the structural compliance of the volute casing in terms of a fluid–structure interaction (FSI). A modelling approach for a one-dimensional representation of the centrifugal pump’s acoustic transmission characteristics in the time and frequency domains is applied to the current pump. As one model parameter, the effective speed of sound in the 1D model needs to be reduced to 607 ms−1 to account for the FSI. The agreement of the simulation results and the experiments underlines the above statement about the influence of the FSI. In a last step, the acoustic excitation parameter, depicted as monopole and dipole amplitudes, at two different blade-passing frequencies (fBP≈[111;169] Hz) are determined for several operating points. Especially for dipole amplitudes, a good agreement between experiments and simulations can be seen. The monopole amplitudes are also of similar orders of magnitude, but show stronger deviations. The cause of discrepancies between the 3D CFD simulations and experiments is believed to be the neglected influence of the FSI and surface roughness as well as the inaccurate reproduction of flow separation at the volute’s tongue due to the use of wall functions. A final important observation made during the numerical investigations is that the excitation mechanisms at the blade-passing frequency are probably independent of the piping system’s acoustic impedance.
Exploring the Interplay between Fatty Acids, Inflammation, and Type 2 Diabetes
Authors: Nicholas Dequina A. , Mbongue Jacques C. , Garcia-Pérez Darysbel , Sorensen Dane , Bennit Heather Ferguson , De Leon Marino , Langridge William H. R.
Published: March 2024

Around 285 million people worldwide currently have type 2 diabetes and it is projected that this number will be surpassed by 2030. Therefore, it is of the utmost importance to enhance our comprehension of the disease’s development. The regulation of diet, obesity, and inflammation in type 2 diabetes is believed to play a crucial role in enhancing insulin sensitivity and reducing the risk of onset diabetes. Obesity leads to an increase in visceral adipose tissue, which is a prominent site of inflammation in type 2 diabetes. Dyslipidemia, on the other hand, plays a significant role in attracting activated immune cells such as macrophages, dendritic cells, T cells, NK cells, and B cells to visceral adipose tissue. These immune cells are a primary source of pro-inflammatory cytokines that are believed to promote insulin resistance. This review delves into the influence of elevated dietary free saturated fatty acids and examines the cellular and molecular factors associated with insulin resistance in the initiation of inflammation induced by obesity. Furthermore, it explores novel concepts related to diet-induced inflammation and its relationship with type 2 diabetes.
Experimental and Numerical Evaluation of Equivalent Stress Intensity Factor Models under Mixed-Mode (I+II) Loading
Authors: Gómez-Gamboa Estefanía , Díaz-Rodríguez Jorge Guillermo , Mantilla-Villalobos Jairo Andrés , Bohórquez-Becerra Oscar Rodolfo , Martínez Manuel del Jesús
Published: March 2024

This study determines the equivalent stress intensity factor (SIF) model that best fits the experimental behavior of low-carbon steel under mixed modes (I and II). The study assessed Tanaka, Richard, and Pook’s equivalent SIF models. The theoretical values used for comparison correspond to the experimental results in a modified C(T) geometry by machining a hole ahead of the crack tip subjected to fatigue loads with a load ratio of R = 0.1. The comparison involved the SIF for six experimental points and the values computed through the numerical simulation. The Paris, Klesnil, and Modified Forman–Newman crack growth models were used with each equivalent SIF to analyze the prediction in the estimated number of cycles. The Klesnil model showed the closest prediction since the error between the calculated and experimentally recorded number of cycles is the lowest. However, the material behavior reflects a reduced crack propagation rate attributed to plasticity in the crack tip. The results suggest that Asaro equivalent SIF conservatively estimates the element lifespan with increasing errors from 2.3% at the start of growth to 27% at the end of the calculation. This study sheds light on the accuracy and limitations of different equivalent SIF models, providing valuable insights for structural integrity assessments in engineering applications.
Improving Fabrication and Performance of Additively Manufactured RF Cavities by Employing Co-Printed Support Structures and Their Subsequent Removal
Authors: Mayerhofer Michael , Brenner Stefan , Doppler Michael , Catarino Luis , Girst Stefanie , Nedeljkovic-Groha Vesna , Dollinger Günther
Published: March 2024

The enormous potential of additive manufacturing (AM), particularly laser powder bed fusion (L-PBF), to produce radiofrequency cavities (cavities) has already been demonstrated. However, the required geometrical accuracy for GHz TM010 cavities is currently only achieved by (a) avoiding downskin angles <40∘, which in turn leads to a cavity geometry with reduced performance, or (b) co-printed support structures, which are difficult to remove for small GHz cavities. We have developed an L-PBF-based manufacturing routine to overcome this limitation. To enable arbitrary geometries, co-printed support structures are used that are designed in such a way that they can be removed after printing by electrochemical post-processing, which simultaneously reduces the surface roughness and thus maximizes the quality factor Q0. The manufacturing approach is evaluated on two TM010 single cavities printed entirely from high-purity copper. Both cavities achieve the desired resonance frequency and a Q0 of approximately 8300.
Objective Quantification of Bilateral Bubble Contrast Echocardiography Correlates with Systemic Oxygenation in Patients with Single Ventricle Circulation
Authors: Phimister Ashley , Bushee Chana , Merbach Monica , Challa Sai Alekha , Pan Amy Y. , Spearman Andrew D.
Published: March 2024

Bubble contrast echocardiography is commonly used to diagnose pulmonary arteriovenous malformations (PAVMs) in single ventricle congenital heart disease (CHD), yet previous studies inconsistently report a correlation between bubble echoes and oxygenation. In this study, we sought to re-evaluate the correlation between bubble echoes and oxygenation by assessing total bilateral shunting and unilateral shunting. We conducted a single-center, retrospective study of patients with single ventricle CHD and previous Glenn palliation who underwent a cardiac catheterization and bubble echocardiogram during the same procedure from 2011 to 2020. Spearman’s rank correlation was performed to examine the relationship between total bilateral shunting and measures of systemic oxygenation, as well as unilateral shunting and ipsilateral pulmonary vein oxygenation. For all patients (n = 72), total bilateral shunting moderately correlated with peripheral oxygen saturation (SpO2) (rs = −0.44, p < 0.0001). For patients with Glenn/Kawashima circulation (n = 49), total bilateral shunting was moderately correlated (SpO2: rs = −0.38, p < 0.01). In contrast, unilateral shunting did not correlate with ipsilateral pulmonary vein oxygenation for any vein measured (p = 0.16–p > 0.99). In conclusion, the total burden of bilateral bubble shunting correlated with systemic oxygenation and may better reflect the total PAVM burden from all lung segments. Unilateral correlation may be adversely influenced by non-standardized approaches to pulmonary vein sampling.
Simulation-Assisted Tool Design for Pulsed Electrochemical Machining of Magnetic Shape-Memory Alloys
Authors: Böttcher Falko , Schaarschmidt Ingo , Edelmann Jan , Schubert Andreas
Published: March 2024

Shape-memory alloys set high demands on the production technologies being used. During cutting, continuous heat input and mechanical stress have an undesirable influence on the shape-memory effect. Pulsed electrochemical machining (PECM), which is based on anodic dissolution, enables force-free machining without thermomechanical influence on the edge-zone properties of the workpiece. Depending on the desired geometry, the development of a customized PECM fixture is necessary. The design of the fixtures is often based on the experiences of the designers and manufacturers, which often results in an estimation of the functionally critical dimensions. For this reason, the study focuses on a methodical approach for evaluating crucial fixture dimensions using knowledge of the specific material dissolution behavior linked with a numerical simulation model. It has been shown that the shape-memory alloy NiMnGa has a non-linear dissolution behavior in sodium nitrate. A reduction of stray currents up to 20% resulting from a lateral gap between the cathode and electrical insulation was demonstrated using numerical simulation. The study shows that a low cathode shaping height has the strongest influence on precise processing. Varying the process parameters allowed for the lateral gap to be adjusted between 0.15 and 0.25 mm.
In Situ Synchrotron Investigations of Beam Diameter Influence on Vapor Capillary Formation during Laser Beam Welding of Copper Alloy with a Blue Laser Beam Source
Authors: Spurk Christoph , Dietrich Frederik , Hummel Marc , Gillner Arnold , Beckmann Felix , Moosmann Julian , Häfner Constantin
Published: March 2024

Laser beam welding as a reliable tool for high-precision joining of batteries or microelectronics is more and more the choice for achieving reproducible results in production processes. In addition to a high automation capability, the precise control of the energy deposition into the material plays an important role, especially when highly reflective materials, such as copper or aluminum, must be welded together. Alongside the use of highly brilliant fiber lasers in the near-infrared range with a focal diameter of a few tens of micrometers, diode lasers in the wavelength range of 445 nm are increasingly being used. Here, beam diameters of a few hundred micrometers can be achieved. With a wavelength of 445 nm, the absorptivity in copper can be increased by more than a factor of 10 compared to a near-infrared laser beam sources in solid state at room temperature. This paper presents the in situ X-ray observation of laser welding processes on CuSn6 with a laser beam source with a wavelength of 445 nm using synchrotron radiation at DESY Petra III Beamline P07 EH4 in Hamburg, Germany. For the experiments, the laser radiation was focused via two separate optics to focal diameters of 362 µm and 609 µm. To characterize the dynamics of the vapor capillaries depending on the different focal diameters dF, the parameters were varied with respect to laser power PL and feed rate v. For the investigations, a synchrotron beam of 2 × 2 mm2 in size with a photon energy of 89 keV was used, and the material samples were analyzed by means of phase-contrast videography to show the boundaries between solid, liquid, and gaseous material phases. The results of this paper show the welding depths achieved and how the geometry of the vapor capillary behaves by changing the focal diameter, laser power and feed rate.
Characterization of Microstructural and Mechanical Properties of 17-4 PH Stainless Steel by Cold Rolled and Machining vs. DMLS Additive Manufacturing
Authors: Moreno-Garibaldi Pablo , Alvarez-Vera Melvyn , Beltrán-Fernández Juan Alfonso , Carrera-Espinoza Rafael , Hdz-García Héctor Manuel , Díaz-Guillen J. C. , Muñoz-Arroyo Rita , Ortega Javier A. , Molenda Paul
Published: March 2024

The 17-4 PH stainless steel is widely used in the aerospace, petrochemical, chemical, food, and general metallurgical industries. The present study was conducted to analyze the mechanical properties of two types of 17-4 PH stainless steel—commercial cold-rolled and direct metal laser sintering (DMLS) manufactured. This study employed linear and nonlinear tensile FEM simulations, combined with various materials characterization techniques such as tensile testing and nanoindentation. Moreover, microstructural analysis was performed using metallographic techniques, optical microscopy, scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), and X-ray diffraction (XRD). The results on the microstructure for 17-4 PH DMLS stainless steel reveal the layers of melting due to the laser process characterized by complex directional columnar structures parallel to the DMLS build direction. The mechanical properties obtained from the simple tension test decreased by 17% for the elastic modulus, 7.8% for the yield strength, and 7% for the ultimate strength for 17-4 PH DMLS compared with rolled 17-4 PH stainless steel. The FEM simulation using the experimental tension test data revealed that the 17-4 PH DMLS stainless steel experienced a decrease in the yield strength of ~8% and in the ultimate strength of ~11%. A reduction of the yield strength of the material was obtained as the grain size increased.
Oxidative Stress and ROS Link Diabetes and Cancer
Authors: Black Homer S.
Published: March 2024

Type 2 diabetes mellitus (T2DM) accounts for one-sixth of deaths globally, whereas cancer is the second leading cause of death in the U.S. T2DM is a known risk factor for many cancers. Reactive oxygen species (ROS)-altered metabolic and signaling pathways link T2DM to cancer. These reprogrammed metabolic and signaling pathways contribute to diabetic complications, impact the redox balance (oxidative stress), and have differential roles in the early and late stages of cancer. A respiratory chain that is highly reduced (as under hyperglycemic conditions) or if reduced cofactors accumulate, ROS are greatly elevated. ROS may cause mutations in mitochondrial DNA (mtDNA) that result in further ROS elevations. The amplification of ROS results in the activation of PKC, an overarching signaling pathway that activates MAPK with a subsequent regulation in several factors that result in pathophysiological manifestations of T2DM and cancer. An upregulation in PKC leads to a deregulation in NF-kß, which regulates the PKB/P13/Akt pathway and orchestrates the cell survival, growth, proliferation, and glucose metabolism manifested in cancer. It also affects Insulin Receptor Substrate (IRS-1), decreasing insulin-stimulated glucose transport and glucose uptake, disrupting subsequent cell signaling pathways contributing to the development of T2DM. Dyslipidemia is a hallmark of T2DM and cancer. ROS-induced lipid peroxidation leads to systemic inflammation, producing inflammatory prostaglandins, cytokines, and chemokines that result in tumor proliferation, rapid tumor growth, and modulation of immunity. The dual role of ROS in the early and late stages of cancer makes antioxidant therapy precarious and may be responsible for controversial results. A system that delivers an antioxidant directly to mitochondria may be useful in inhibiting the formation of ROS early during the pre-diabetic stage, whereas antioxidant therapy must be halted in later stages to retard metastasis.
Statistical Analysis of Ice Load on Icebreaker Ship Based on Stochastic Ice Fields
Authors: Li Liang , Han Guangchun , Ji Shunying
Published: March 2024

Accurately assessing ice loads is a fundamental issue in the field of structural design for ships in ice-covered regions. In this paper, we conducted research on extreme ice load estimation for icebreaking ships, combining stochastic theory with numerical simulation. Firstly, using sea ice data from the Arctic region of the United States National Snow and Ice Data Center, a stochastic ice field model was established under Arctic sea ice conditions using non-parametric estimation and the rejection sampling method, and ice field data were generated stochastically. Then, based on the stochastic ice field data, a three-dimensional numerical model of the interaction between the ice field and the ship hull was established, and the reliability of the numerical model was verified by experimental results. Finally, based on the numerical model of the interaction between the ice field and the ship hull, asymptotic methods were used to study the extreme ice load estimation in different parts of the ship hull, revealing the variation law of the extreme ice load in different parts of the ship hull. This study provides basic theory and technical support for the structural design of ships in polar regions and has engineering application value.
Airway Stents in Interventional Pulmonology
Authors: Bashour Sami I. , Lazarus Donald R.
Published: March 2024

Airway stents, first developed in the 1980s, have become fundamental in managing a multitude of airway pathologies and complications within the field of interventional pulmonology. The primary function of an airway stent is to re-establish airway patency and integrity when obstruction, stenosis, anastomotic dehiscence, or fistulae develop as a result of various malignant or benign conditions. Nevertheless, airway stents are foreign bodies that can result in complications. In this review article, we will discuss airway stents and their ongoing role in the management of several malignant and benign diseases. We will describe indications for airway stenting and review the elements that must be taken into consideration for optimal patient and stent selection. Given the prevalence of data regarding therapeutic bronchoscopy and airway stenting in malignant airway obstruction, much of the discussion in this review will focus on stent placement for that indication. We will also review the data as it pertains to safety, efficacy, and complications after stent placement, and conclude with a discussion of the future applications and research avenues related to airway stents.
The Impact of Non-Interest Income on Commercial Bank Profitability in the Middle East and North Africa (MENA) Region
Authors: Abu Khalaf Bashar , Awad Antoine B. , Ellis Scott
Published: March 2024

This study examines the effects of non-interest income on bank performance in the Middle East and North Africa (MENA) region, addressing existing research gaps and conflicting results. The analysis is based on data from 40 banks (5 banks from each country) operating in Bahrain, Egypt, Jordan, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates between 2010 and 2022. Using correlation analysis and three regression models (OLS, FE, and RE), this study explores the relationship between non-interest income, overheads, capital adequacy, loan loss provision, bank size, and return on assets. The findings reveal positive associations among banks’ overhead, size, capital adequacy, and loan loss provision. Additionally, a favorable correlation is observed between non-interest income and bank performance. Non-interest income significantly influences the profitability of MENA region banks across all three models, supporting the main hypothesis. While the study’s limitations include sample size and geographic focus, the findings of this study provide valuable insights for policymakers, allowing them to recognize the positive impact of increasing non-interest income on commercial bank profitability in the MENA region and consider implementing policies that encourage and support banks in diversifying their income sources.
Enhancing the Management of Pediatric Sickle Cell Disease by Integrating Functional Evaluation to Mitigate the Burden of Vaso-Occlusive Crises
Authors: Boma Paul Muteb , Kaponda Alain Ali , Panda Jules , Bonnechère Bruno
Published: March 2024

Sickle cell disease (SCD) imposes a significant health burden, particularly in low- and middle-income countries where healthcare professionals and resources are scarce. This opinion paper delves into the management strategies employed for vaso-occlusive crises (VOCs) in pediatric patients with SCD, advocating for the adoption of a transformative strategy. We explore the integration of functional assessment approaches into existing procedures, highlighting the potential of technology-assisted rehabilitation, including wearable sensors and digital biomarkers, to enhance the effectiveness of managing and preventing VOCs. Rehabilomics, as a comprehensive framework, merges rehabilitation-related data with biomarkers, providing a basis for personalized therapeutic interventions. Despite the promising advantages of these approaches, persistent obstacles such as the limited availability of rehabilitation programs, especially in resource-limited settings, pose challenges. This paper underscores the importance of a collaborative strategy to effectively address the unique obstacles faced by patients with SCD. This collaborative approach involves improving accessibility to rehabilitation services, incorporating technology-supported therapy, and fostering focused research endeavors. The primary objective of this comprehensive approach is to enhance the overall care of SCD patients, with a specific focus on preventing VOCs, as well as providing tailored (neuro)rehabilitation services in resource-limited settings. By examining the current state of SCD management and proposing transformative strategies, this opinion paper seeks to inspire collective action and collaboration to improve outcomes for pediatric SCD patients globally.
Exploring the Land Cover Material Interaction of Urban Open Space on the Thermal Comfort of Crowds in High-Temperature Environments and Retrofit Strategies: Two Case Studies in the Nanjing Xinjiekou District
Authors: Tan Ying , Li Chen , Feng Haiyi , Yang Junyan
Published: March 2024

The increased frequency of extreme hot weather events in recent years poses a significant threat to the lives and health of urban residents. Consequently, the thermal comfort of urban open areas has garnered growing attention. The ground material in these urban open areas directly impacts the thermal environment, which significantly influences the comfort of crowds. This study aimed to assess the effect of land cover materials in urban center squares on the thermal comfort of people in high-temperature conditions. Eight types of land cover materials were selected from the two urban squares in the central district of Nanjing Xinjiekou. Physiological equivalent temperature (PET) calculations were performed by measuring the surface temperature, the air temperature, the humidity, and other relevant data to evaluate population thermal comfort. The findings indicated that grass provided the highest thermal comfort, with PET scores ranked as follows, from low to high: grass, permeable bricks, granite, concrete, basalt, bluestone, andesite, and asphalt. Additionally, factors such as color, roughness, and shade within the same material also impacted thermal comfort. Subsequently, using the ENVI-met 5.1 software, surface materials exhibiting superior thermal comfort were simulated for replacement, aiming to confirm the experimental results and propose retrofit strategies for improving urban square thermal comfort by optimizing material selection. The outcomes of this study hold significant implications for urban open space design and the overall well-being of city dwellers. The thermal environment in urban centers during high-temperature conditions can be improved by optimizing the choice of land cover materials in urban open areas, thereby enhancing the comfort of the population.
Lipidology: A New Open Access Journal
Authors: Ferri Nicola
Published: March 2024

On behalf of all the Editorial Board members and MDPI staff, I am pleased to announce the publication of the inaugural issue of the Lipidology journal [...]