bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effectiveness of a Program Visualization Tool on Introductory Programming: A Case Study with PythonTutor
Authors: Karnalim Oscar , Ayub Mewati
Published: March 2018

Program Visualization (PV) is an educational tool frequently used to assist users for understanding a program flow. However, despite its clear benefits, PV cannot be incorporated easily on Introductory Programming course. Several key properties such as student characteristics and behavior should be considered beforehand. This paper is intended to provide an empirical review about the impact of PV toward students of Introductory Programming course. For our case study, PythonTutor is selected as a sample of PVs due to its accessibility. It can be accessed anywhere and anytime through a web browser. Three conclusions are obtained based on our evaluation on data collected from a survey. Firstly, PV is quite effective to assist students for conducting several programming sub-tasks. Secondly, PV, at some extent, may help students to learn advanced topics on Introductory Programming course. Finally, despite the fact that several features should be incorporated to enhance understanding of students, PV is beneficial for learning Introductory Programming course, especially when it is frequently used.
Network Security Analysis in Vanet Against Black Hole and Jellyfish Attack with Intrusion Detection System Algorithm
Authors: Mustikawati Elsa , Perdana Doan , Negara Ridha Muldina
Published: March 2018

VANET is the key to the Intelligent Transportation Systems (ITS), where vehicles can communicate with others to exchange information in real time. VANET is an ad-hoc that has no fixed infrastructure and rapidly changing network topology. As the result, the network is insecure and vulnerable to various attacks both from within and outside the network. This research analyzes AODV routing protocol comparing the conditions without the attacks and with the attacks with the of black hole and jellyfish using the algorithm of Intrusion Detection System with the number of nodes changing from 10 to 100 nodes at the change speeds of 70, 80, 90, 100, 110, and 120 km/h. This research is simulated using Network Simulator 2 to model the network and ONESimulator to model node mobility. The analyzed QoS parameters are packet delivery ratio (PDR), throughput, and end-to-end delay. The results of the simulation show that changing the number of nodes and node velocity affects the performance in the network. On the number of nodes scenario with attacks, the average value of PDR decreases by 48.03%, throughput decreases by 50.23%, and delay, for black hole, decreases by 80.18% but increases by 47.87% for jellyfish. Whereas in the node velocity scenario, the average values of PDR, throughput, and delay decrease by 58.52%, 60.34%, 13.81% for blackhole attack, respectively. However, the delay increases by 123.91% for jellyfish attack.
Development of Asset Management Control Application for Direktorat Jenderal Sumber Daya dan Perangkat Pos dan Informatika
Authors: Richard Richard
Published: March 2018

The purpose of this research was to identify problems, analyze needs, and develop management information system especially the process internal control of asset management on Direktorat Jenderal Sumber Daya dan Perangkat Pos dan Informatika (SDPPI - government communication and informatics organization). This system development used the System Development Life Cycle (SDLC) method which refers to 4 phases. Those were initiation and business feasibility, requirements definitions, functional design, and verification. The analysis used to support the research methods was Enterprise Architecture (EA) and SWOT. The analysis was conducted on business process that was running at the moment. The results show that the management information system in the form of web-based applications can help the process based on activity logging assets, assets allocation, complaints, and user guide in accordance with the needs of the Direktorat Jendral SDPPI. The design of this application can also help the existing asset management process to become more efficient and effective.
Indonesian News Harvester and Recommender System
Authors: Wibowo Adi , Intan Rolly , Valentina Nydia
Published: March 2018

To provide convenience for the user that frequently read the news, a system to gather, classify, and provide news from several news websites in one place was needed. This system utilized a recommender system to provide only relevant news to the user. This research proposed a system architecture that used vector space model, and Rocchio relevance feedback to provide specific news recommendation to user’s feedback. The results are that the proposed system architecture can achieve the goal by using five levels of feedback from the user. However, the time needed to gather news is increasing exponentially in line with the number of terms gathered from articles.
Analysis of Wollongong City Council using 7s’s of Galliers and Sutherland Methods
Authors: Gamayanto Indra
Published: March 2018

The research analyzed website of Wollongong City Council (WCC) and all the plans done by the WCC. It also showed details an Information Systems (IS) strategic plan for WCC. Although the WCC already had an integrated system, there were several key issues. The framework used to devise IS plan was seven stages (7S) of Gallier and Sutherland (G&S). The approach assisted WCC in locating the current stage of its Information Technology (IT) maturity. From the analysis undertaken, it finds that IT currently is within stages 4 and stage 5 in seven stages. The final result will be the framework of the design as recommendations to the WCC.
Question Categorization using Lexical Feature in Opini.id
Authors: Saputra Christian Eka , Suhartono Derwin , Wongso Rini
Published: March 2018

This research aimed to categorize questions posted in Opini.id. N-gram and Bag of Concept (BOC) were used as the lexical features. Those were combined with Naïve Bayes, Support Vector Machine (SVM), and J48 Tree as the classification method. The experiments were done by using data from online media portal to categorize questions posted by user. Based on the experiments, the best accuracy is 96,5%. It is obtained by using the combination of Bigram Trigram Keyword (BTK) features with J48 Tree as classifier. Meanwhile, the combination of Unigram Bigram (UB) and Unigram Bigram Keyword (UBK) with attribute selection in WEKA achieves the accuracy of 95,94% by using SVM as the classifier.
Benthix VR: A Virtual Reality Simulation Application to Preserve Traditional Benthik Game
Authors: Setiawan Abas , Nugraha Alvin Satria , Haryanto Hanny , Gamayanto Indra
Published: March 2018

This research aimed to preserve Benthik traditional game using Benthix VR. Benthix VR used the Virtual Reality Interface Design (VRID) development model. The development phase of the VRID model started from High Level to Low-Level phase. The High-Level Design (HLD) phase consisted of identifying data elements and multiple objects, and modeling component objects. The output from the HLD phase would be input to the Low-Level Design (LLD) phase. The LLD phase was a phase of repetition and fine-tunes from the modeling of several component objects thoroughly. Testing of Benthix VR was conducted on 34 respondents with five assessment aspects. Those were enjoyment, realism, interactivity, usability, and impact. The average result of the questionnaire assessment of all aspects is 3,18824. These results indicate that users feel that Benthix VR is comfortable, realistic, interactive, and fascinating. Moreover, they are also interested in playing Benthik in the real world after using the application.
Revolting Against Imperialism and Capitalism in Sherlock Holmes: a Game of Shadows (2011)
Authors: Adji Alberta Natasia
Published: March 2018

The purpose of the study was to reveal the struggle among imperialism, capitalism, and social class dominance found within Guy Ritchie’s A Game of Shadows (2011), which was set in Britain, France, and Germany in 1891. British imperialism, capitalism, and social class were very well-related since they formed the basic classic social tradition in European countries that confined minorities such as working-class people and immigrants. The study was particularly focused on (1) the imperialist and capitalist representations were portrayed by Professor Moriarty as the much honoured academic figure who was able to disguise his criminal activities, and (2) the revolt of the marginalized people which were represented by the working-class; Gypsy immigrant minorities who are isolated from the imperialist West European social class strata. The study was conducted using the perspectives of AJ Greimas’ narrative structure through identifying all of the sequences and actantial models of the film, as well as relating them to capitalism and social class issues. The result of the study shows that the film has managed to show the success in fighting against imperialism and capitalism that initially determine the characters’ positions.
Gestalt Principles Applied on Visual Identity in Bogor City
Authors: Suprayitno Suprayitno
Published: March 2018

This study was a review on the problem of rules of logo design principles used in visual identity in the city of Bogor at random. The purpose of this study was to provide input and a better visual identity approach in accordance with the principles of design. One of the theories used was the theory of Gestalt Max Wertheimer. The theory was used to dissect some examples of visual identity in the area especially the city of Bogor. The research applied qualitative research methods, including data collection in the form of literature study, accompanied by observation and documentation. The results of this research are in the form of suggestions and inputs in designing a visual identity or logo, with applied Gestalt principles as one approach to visual solutions more unique and interesting. So the identity of a brand becomes more memorable.
The Relationship of Exhibition Space Design and the Success of Delivering Messages to Museum Visitors in Jakarta
Authors: Wulandari Anak Agung Ayu , Fajarwati Ade Ariyani Sari , Latif Fauzia
Published: March 2018

The research explored exhibition space designs, particularly the interior design elements such as circulation, lighting, and display techniques to find out whether the design elements corresponded the design principles and to find out which museum had the most ideal exhibition design that was able to deliver exhibition messages to the audience. The research applied qualitative method with case study approach in three museums in Jakarta, those were National Museums, Bank of Indonesia museum, and museum of Fine Art and Ceramic as case studies and qualitative data collecting methods through observations to get real-settings information. Data analysis and comparison of various interior elements shows that from the three case studies only Bank of Indonesia Museum has an integrated exhibition space using various interior elements; circulation and lighting design as well as display technique that support the success of a museum to deliver exhibition messages to their visitor. It can stimulate visitors senses visually, auditory, and kinetic.
Effectiveness of a Brief Mindfulness Based Intervention to Promote Posttraumatic Growth in Cancer Patients
Authors: Nurfadhilah Nurfadhilah , Widyastuti Widyastuti , Ridfah Ahmad
Published: March 2018

The purpose of this study was to determine the effectiveness of a brief mindfulness based intervention to promote posttraumatic growth in cancer patients. The research design used was untreated control group design with pretest and posttest samples. Subjects in this study were 21 cancer patients that were divided into an experimental group (n = 10) and a control group (n = 11). Data were analyzed using Anova Mixed Design. The analysis showed significant changes of posttraumatic growth in the experimental group (MD=-14,400; p=0,000, p<0,05) and in the control group changes of posttraumatic growth were not significant (MD=-0,273, p=0,914, p>0,05). The results show that a brief mindfulness based intervention, which in this case is mindfulness training and yield significant results towards increased scores of posttraumatic growth in cancer patients. Hence, mindfulness based intervention can be used as one of psychotherapy to help individual psychologically growth.
Cultural Acculturation in Interior and Architecture of Old Straits-Born Chinese Lasem House
Authors: Rachmayanti Sri , Rusli Christianto , Wulandari Anak Agung Ayu
Published: March 2018

The long-term goal of this research was to make variety ornament documentation on architecture and the interior of Indonesian historical buildings, especially for buildings having the combination between western and eastern. The original plan of this research was to achieve some cultural preservation efforts, they were (1) to find various styles of design art, including the variety of native straits-born Chinese ornaments, Art Deco, and Neoclassical, or found that there are any acculturations among the ornaments in an interior. (2) To understand characteristics of each style and applied it appropriately in the interior space. (3) To find on how the building functioned and how to preserve as cultural heritage. The method began with a survey, interviews, and observations by documenting the application of Indonesia art and culture for cultural conservation, especially on interior design. The case study was straits-born Chinese buildings in Lasem, Central Java. The observation and research concerned with design styles applied in architecture, interior, and home decoration. The observation and research were followed by summarizing and analyzing the material obtained from field surveys result by comparing two samples of Chinese houses in Lasem that also supported with literature research. Researchers find several differences of art styles which had been applied. The styles are original Chinese decorations, Art Deco, and Neoclassical decorations.
Tax Amnesty Role in Developing National Public Welfare
Authors: Tukina Tukina
Published: March 2018

This article was a descriptive qualitative research. The discussion conducted with descriptive analysis. Basic analysis of the study used observation, seminar, and literature review from the web, book, and journal. The study focused on the national development, tax amnesty, and repatriation. It finds that the most important thing for the people, especially under the economic development, is the public welfare and prosperity that are achieved by tax conducted by the government. The making of tax policy, repatriation, and tax amnesty need to be preceded by the academic paper earnestly and profoundly as a basic philosophical, social, and cultural that can be accepted by the people of Indonesia.
Learning Polygons using English Language
Authors: Willyarto Mario Nugroho
Published: March 2018

The authors conducted a study related to using English in learning mathematics, for grade 7 junior high school students in a private national plus school. The purpose of this study was for the reader to open up further insights related to the topic. This study was carried out with experimental design, by doing different treatment between classes in the same level. The subjects of the study consisted of 63 students spread into three classes; 7A, 7B, and 7C. Class 7C was a control group, using Bahasa Indonesia (mother tongue) in learning Mathematics. Class 7A and 7B were the experimental groups, where 7A was in English and 7B used bilingual (English and Indonesian). Results of the study include the following; using English is not detrimental to the students in mark achievement that is shown by the average of the final mark of Mathematics that is not significantly different. The challenges that arise from learning Mathematics need to be reviewed from the process, readiness, independence, motivation of students and needs to be followed up critically so that students can achieve better results. Short and long-term programs need to be created and observed in order to support the learning process of Mathematics for students, such as training teachers to be able to teach mathematics in English, in supporting action study by teachers, managed by the school.
Significantly photoinduced synergy between sodium sulfite and ammonium nitrate and the mechanism study
Authors: Hu Wen-Na , Liu Jian , Liu Wei , Zhang Xian-Feng
Published: March 2018

In this paper, a significantly photoinduced synergy between ammonium nitrate and sodium sulfite via dye decolorization was first found. This study mainly aims to explore the influences of several fundamental aspects on the photoinduced synergy as well as discuss the detailed mechanisms. The dye removal efficiencies of methyl orange and methylene blue of the synergistic system are much higher than that of a single one, and they reach 96.4% and 90.7% when the illumination is 6 and 14 min, respectively. The optimum mass ratio of sodium sulfite and ammonium nitrate in the reaction system is 1:1. The reaction process of photoinduced synergy follows the first-order reaction equation. Effects of different structures of dyes, amount of sodium sulfite and initial dye concentration on the synergistic effect were investigated. The changes of UV-vis spectra in the course of photoinduced synergy were also examined. The excellent synergistic effect can owe to the simultaneous photoreduction and photooxidation reaction with respect to photoinduced hydrated electrons (eaq−) and SO4•− active species, respectively. This work may provide some insight into detoxifying water contaminants in practical applications as well as developing other novel photoinduced synergistic systems with high performance.
Use of the terrestrial weed Alternanthera ficoidea in treating greywater in soil-less SHEFROL® bioreactors
Authors: Abbasi S. A. , Tauseef S. M.
Published: March 2018

The ornamental plant Alternanthera ficoidea (also named A. tenella), which is common and widespread throughout the tropics and is being increasingly regarded as an invasive, problematic weed, has been explored as a bioagent in greywater treatment. In the recently developed SHEFROL® bioreactor, it was seen to treat greywater of varying strengths (250–1,300 mg/L chemical oxygen demand, COD) quickly and substantially to the extent of 75–77%. Biological oxygen demand (BOD), nitrogen, phosphorus, suspended solids, and heavy metals copper, nickel, manganese, and zinc were also removed to the extents of 83.5, 94.9, 33.1, 27.0, 44.8, 27.5, 38.2, and 43.2%, respectively. As all this was achieved in a single pot, single step, and in a simple reactor operation, at hydraulic retention times of a mere 6 h, it shows the process to be several times more efficient as well as potentially less expensive than the conventional treatment systems which utilize macrophytes in tanks or constructed wetlands.
Enucleation Induces Parvalbumin and Glial Fibrillary Acidic Protein, but Not Calbindin D28k Protein Expression in Superior Colliculus of Wistar Rats
Authors: Gonzalez Daniel , Afadlal Szeifoul , Lizal Kristin , Hermanto Yulius , Miki Takanori , Takeuchi Yoshiki , Satriotomo Irawan
Published: March 2018

Background: It is known that eye enucleation causes various morphological and functional alterations in the central nervous system (CNS). The purpose of this study was to examine the sub-chronic effects of monocular enucleation on the distribution of the calcium binding proteins calbindin D28k (CB) and parvalbumin (PV) as well as the glial fibrillary acidic protein (GFAP) immunoreactivity in the superior colliculus (SC) of Wistar rats.Materials and Methods: Thirty young adult (8 weeks) male Wistar rats from SLC (Shizuoka, Japan), weighing 200-250 grams, were housed in separate cages under controlled conditions with a constant temperature kept in 12:12 light/dark cycle and ad libitum water and food. In this study the rats were divided into two groups, a control and an enucleated groups. The experimental group received unilateral eye enucleation and was allowed 1, 4 or 12 weeks recovery before sacrificed.Results: Unilateral enucleation over a period of 1 week or more caused a decrease in the number CB-immunoreactive (CBIR) neurons. This loss was associated with an increase in GFAP-IR astrocytes in the superficial gray layer and the optic layer of the SC with contralateral side predominance. In addition, the CB-IR neurons illustrated a smaller soma and poor dendritic arborization. Conversely, the GFAP-IR astrocytes were hypertrophied with longer foot processes on the contralateral side of enucleation. Interestingly, the number of PV-IR neurons was elevated for up to 4 weeks in enucleated rats versus shamoperated rats.Conclusion: This study demonstrates the importance of calcium-binding protein homeostasis and reversible glial response for maintaining variability of neuronal function in sub-cortical visual centers following optic nerve deafferentation.Keywords: enucleation, superior colliculus, calbindin D28k, parvalbumin, glial fibrillary acidic protein
Synthesis and Kinetics of Highly Substituted Piperidines in the Presence of Tartaric Acid as a Catalyst
Authors: Ghalandarzehi Younes , Shahraki Mehdi , Habibi-Khorassani Sayyed M.
Published: March 2018

Aim & Scope: The synthesis of highly substituted piperidine from the one-pot reaction
between aromatic aldehydes, anilines and β-ketoesters in the presence of tartaric acid as a catalyst
has been investigated in both methanol and ethanol media at ambient temperature. Different
conditions of temperature and solvent were employed for calculating the thermodynamic parameters
and obtaining an experimental approach to the kinetics and mechanism. Experiments were carried
out under different temperature and solvent conditions.

Material and Methods:

Products were characterized by comparison of physical data with authentic
samples and spectroscopic data (IR and NMR). Rate constants are presented as an average of several
kinetic runs (at least 6-10) and are reproducible within ± 3%. The overall rate of reaction is followed
by monitoring the absorbance changes of the products versus time on a Varian (Model Cary Bio-
300) UV-vis spectrophotometer with a 10 mm light-path cell.

Results:

The best result was achieved in the presence of 0.075 g (0.1 M) of catalyst and 5 mL
methanol at ambient temperature. When the reaction was carried out under solvent-free conditions,
the product was obtained in a moderate yield (25%). Methanol was optimized as a desirable solvent
in the synthesis of piperidine, nevertheless, ethanol in a kinetic investigation had none effect on the
enhancement of the reaction rate than methanol. Based on the spectral data, the overall order of the
reaction followed the second order kinetics. The results showed that the first step of the reaction
mechanism is a rate determining step.

Conclusion:

The use of tartaric acid has many advantages such as mild reaction conditions, simple
and readily available precursors and inexpensive catalyst. The proposed mechanism was confirmed
by experimental results and a steady state approximation.
Effects of Estrogen in Gender-dependent Fetal Programming of Adult Cardiovascular Dysfunction
Authors: Chen Zewen , Wang Lei , Ke Jun , Xiao Daliao
Published: March 2018

Background: Epidemiological studies and experimental studies have demonstrated that intrauterine adverse environment increases the risk of Cardiovascular Disease (CVD) in adulthood. However, whether an individual develops a cardiovascular dysfunctional phenotype may depend on genetic background, age, and sex.  Methods: In this review, we summarize some of the recent experimental animal studies in the developmental programming of adult CVD with an emphasis on sex differences and the potential role of estrogen in mediating sexual dimorphism.  Results: Few epidemiological studies report the effect of sex on the developmental programming of CVD. However, numerous experimental animal studies have shown a sex difference in fetal programming of adult cardiovascular dysfunction. Most of the animal studies indicate that male offspring develop cardiovascular dysfunction and CVD in adulthood, whereas adult females appear to be protected. Estrogen is one of the key factors that contributes to the sex difference of adult CVD. Estrogen/its Receptor (ER) may interact with the RAS system by changes of DNA methylation patterns at the target gene promoter, serve as an antioxidant to counteract the prenatal insults-induced heightened ROS, and function as an eNOS activator to increase vasodilation, resulting in the protection of female offspring from the development of hypertension and other CVDs.  Conclusion: These studies suggest that estrogen/ER may contribute to sex differences in cardiovascular response to an adverse intrauterine environment and play a significant role in modulating the cardiovascular response in adulthood.
A Systematic Review on Popularity, Application and Characteristics of Protein Secondary Structure Prediction Tools
Authors: Kashani-Amin Elaheh , Tabatabaei-Malazy Ozra , Sakhteman Amirhossein , Larijani Bagher , Ebrahim-Habibi Azadeh
Published: March 2018

Background:

Prediction of proteins’ secondary structure is one of the major steps in the generation
of homology models. These models provide structural information which is used to design suitable
ligands for potential medicinal targets. However, selecting a proper tool between multiple Secondary
Structure Prediction (SSP) options is challenging. The current study is an insight into currently favored
methods and tools, within various contexts.

Objective:

A systematic review was performed for a comprehensive access to recent (2013-2016) studies
which used or recommended protein SSP tools.

Methods:

Three databases, Web of Science, PubMed and Scopus were systematically searched and 99
out of the 209 studies were finally found eligible to extract data.

Results:

Four categories of applications for 59 retrieved SSP tools were: (I) prediction of structural features
of a given sequence, (II) evaluation of a method, (III) providing input for a new SSP method and
(IV) integrating an SSP tool as a component for a program. PSIPRED was found to be the most popular
tool in all four categories. JPred and tools utilizing PHD (Profile network from HeiDelberg) method occupied
second and third places of popularity in categories I and II. JPred was only found in the two first
categories, while PHD was present in three fields.

Conclusion:

This study provides a comprehensive insight into the recent usage of SSP tools which
could be helpful for selecting a proper tool.
Critical Insight into the Design of PPAR-γ Agonists by Virtual Screening Techniques
Authors: Thangavel Neelaveni , Al Bratty Mohammed , Javed Sadique Akhtar , Ahsan Waquar , Alhazmi Hassan A.
Published: March 2018

Background:

Design of novel PPAR-γ modulators with better binding efficiency and
fewer side effects to treat type 2 diabetes is still a challenge for medicinal chemists. Cost and time
efficient computational methods have presently become an integral part of research in nuclear
receptors and their ligands, enabling hit to lead identification and lead optimization. This review will
focus on cutting-edge technologies used in most recent studies on the design of PPAR- γ agonists and
will discuss the chemistry of few molecules which emerged successful.

Methods:

Literature review was carried out in google scholar using customized search from 2011-
2017. Computer-aided design methods presented in this article were used as search terms to retrieve
corresponding literature.

Results:

Virtual screening of natural product libraries is an effective strategy to harness nature as the
source of ligands for PPARs. Rigid and induced fit docking and core hopping approach in docking
are rapid screening methods to predict the PPAR- γ and PPAR-α/ ཫ dual agonistic activity. Onedimensional
drug profile matching is one of the recent virtual screening methods by which an
antiprotozoal drug, Nitazoxanide was identified as a PPAR- γ agonist.

Conclusion:

It is concluded that to achieve a convincing and reliable design of PPAR-γ agonist by
virtual screening techniques, customized workflow comprising of appropriate models is essential in
which methods may be applied either sequentially or simultaneously.
Combined Office-based Vergence Therapy and Home Therapy System for Convergence Insufficiency in Egyptian Children
Authors: Nehad Tarek , Salem Tamer , Elmohamady Mohamed Nagy
Published: March 2018

Background:

Convergence Insufficiency (CI) is a common binocular vision disorder characterized by exophoria more at near than at far, a receded Near Point of Convergence (NPC), and decreased Positive Fusional Vergence (PFV) at near. This disorder is often associated with several symptoms that may disturb the person’s quality of life. Therefore, diagnosis and treatment of CI is a vital issue.

Objectives:

To compare therapeutic yield of Office Based Vision Therapy (OBVT) and combined OBVT with Home Therapy System (HTS) in patients with CI.

Methods:

The study included 102 patients with age range of 7-13 years. All patients underwent Convergence Insufficiency Symptom Survey (CISS) scoring, estimation of Near Point of Convergence (NPC) and determination of Positive Fusional Vergence at near (PFV) using Sheard’s criterion. Patients were randomly allocated in two groups: Group I: received Office-based Vision Therapy (OBVT) and Group II: received OBVT with home reinforcement using the Home Therapy System (HTS). At the end of 12th week of therapy; outcome was determined as Successful (all the following: CISS score of <16, NPC <6 cm and PFV >15Δ), Improved (CISS score of <16 or a 10 points-decrease and one of the following: NPC <6cm or improved by >4 cm, PFV >15Δ or increased by > 10Δ), Insufficient response (NPC <6cm or improved by >4 cm, PFV >15Δ or increased by > 10Δ) and non-responders.

Results:

At the end of the 12th week of therapy, the applied therapeutic polices were successful in 48 patients (47.1%), the symptoms were improved in 30 patients (29.4%), improvement was insufficient in 13 patients (12.7%) and 11 patients (10.8%) were considered as non-responders. There was significantly higher frequency of patients with improved outcome in group II (86%) compared to group I (69.2%).

Conclusion:

OBVT with home supplement using HTS provided a high success rate, and it seems to be superior to OBVT alone in treatment of children with convergence insufficiency after 12-week course of therapy.
Central Hemangioma Involving the Mandible: A Rare Condition: Case Report and Review of Literature
Authors: Kamath Jasmine Shanthi , Kini Raghavendra , R Sangeetha , Murukan Sivakumar , Naik Vathsala , Madiyal Ananya
Published: March 2018

Intraosseous
hemangiomas are quite a rare condition and those occurring in the mandible
often pose a diagnostic dilemma to the Dental surgeon as they present with variable and atypical radiographic manifestations. Biopsy or surgical excision of the
lesion can result in severe haemorrhage, leading even to death; therefore
accurate clinical and radiographic diagnosis is essential before any surgical
intervention is started. In this paper, we discuss a
case of central hemangioma of the mandible occurring in a 17-year-old male
patient, angiography was used for diagnosis and was treated with surgical
excision.

 İntraosseöz hemanjiomlar ender görülen bir durumdur ve
mandibulada görülen hemanjiyomlar sıklıkla dişhekimleri için değişken ve atipik
radyografik bulgularla ortaya çıktığı için tanı ikilemi oluştururlar. Biyopsi
ya da lezyonun cerrahi olarak eksizyonu ciddi kanamalara neden olabilir, ölümle
bile sonuçlanabilir; bu nedenle herhangi bir cerrahi işleme başlamadan önce
doğru klinik ve radyolojik tanı gereklidir. Bu yazıda, 17 yaşındaki erkek
hastada mandibulanın santral hemanjiyom olgusu tartışılmıştır. Anjiyografi tanı
için kullanılmış ve cerrahi eksizyon ile tedavi edilmiştir.
Integrating Social Determinants of Health into Dental Curricula: An Interprofessional Approach
Authors: Sabato Emily , Owens Jessica , Mauro Ann Marie , Findley Patricia , Lamba Sangeeta , Fenesy Kim
Published: March 2018

Approaching patient care from a holistic perspective, incorporating not only the patient's medical and dental history but also psychosocial history, improves patient outcomes. Practitioners should be trained to provide this style of care through inclusive education, including training working on interprofessional teams. A component of this education must incorporate social determinants of health into the treatment plan. Social determinants of health include income, race/ethnicity, education level, work opportunities, living conditions, and access to health care. Education regarding social determinants of health should be woven throughout dental curricula, including hands‐on application opportunities. This education must extend to patient care situations rather than be limited to didactic settings. This article explains the need to incorporate social determinants of health into dental education and illustrates how social determinants education is being addressed in two U.S. dental schools’ curricula, including how to weave social determinants of health into interprofessional education. These descriptions may serve as a model for curricular innovation and faculty development across the dental education community.
How Twitter Can Support the HIV/AIDS Response to Achieve the 2030 Eradication Goal: In-Depth Thematic Analysis of World AIDS Day Tweets (Preprint)
Authors: Odlum Michelle , Yoon Sunmoo , Broadwell Peter , Brewer Russell , Kuang Da
Published: March 2018

BACKGROUND

HIV/AIDS is a tremendous public health crisis, with a call for its eradication by 2030. A human rights response through civil society engagement is critical to support and sustain HIV eradication efforts. However, ongoing civil engagement is a challenge.

OBJECTIVE

This study aimed to demonstrate the use of Twitter data to assess public sentiment in support of civil society engagement.

METHODS

Tweets were collected during World AIDS Days 2014 and 2015. A total of 39,940 unique tweets (>10 billion users) in 2014 and 78,215 unique tweets (>33 billion users) in 2015 were analyzed. Response frequencies were aggregated using natural language processing. Hierarchical rank-2 nonnegative matrix factorization algorithm generated a hierarchy of tweets into binary trees. Tweet hierarchy clusters were thematically organized by the Joint United Nations Programme on HIV/AIDS core action principles and categorized under HIV/AIDS Prevention, Treatment or Care, or Support.

RESULTS

Topics tweeted 35 times or more were visualized. Results show a decrease in 2015 in the frequency of tweets associated with the fight to end HIV/AIDS, the recognition of women, and to achieve an AIDS-free generation. Moreover, an increase in tweets was associated with an integrative approach to the HIV/AIDS response. Hierarchical thematic differences in 2015 included no prevention discussion and the recognition of the pandemic’s impact and discrimination. In addition, a decrease was observed in motivation to fast track the pandemic’s end and combat HIV/AIDS.

CONCLUSIONS

The human rights–based response to HIV/AIDS eradication is critical. Findings demonstrate the usefulness of Twitter as a low-cost method to assess public sentiment for enhanced knowledge, increased hope, and revitalized expectations for HIV/AIDS eradication.
Activated Carbon from Spent Brewery Barley Husks for Cadmium Ion Adsorption from Aqueous Solution
Authors: Osasona Ilesanmi , Aiyedatiwa Kayode , Johnson Jonathan , Faboya Oluwabamise Lekan
Published: March 2018

This study investigated the feasibility of using acid activated carbon prepared from brewery spent barley husks for the adsorption of cadmium from aqueous solution. The effects of operation parameters such as pH, contact time, adsorbent dosage, concentration and temperature were verified. The amount of cadmium adsorbed increased with increase in solution pH, initial solution concentration and with the amount of adsorbent dosed. A time of 5 minutes was required for attainment of equilibrium. The equilibrium data obtained were analysed using both Langmuir and Freundlich isotherm models and the data were better described by Langmuir model with correlation coefficient of 0.9183. The thermodynamic parameters revealed that the removal of cadmium by the activated carbon was exothermic and spontaneous. Thus, activated carbon obtained from brewery spent barley husk can be employed as an economically viable low-cost adsorbent for removing cadmium from aqueous solution.
Improvement of Cycling Performance of Na2/3Co2/3Mn1/3O2 Cathode by PEDOT/PSS Surface Coating for Na Ion Batteries
Authors: Ni’mah Yatim Lailun , Cheng Ju Hsiang , Cheng Ming Yao , Su Wei Nien , Hwang Bing Joe
Published: March 2018

The surface-modified Na2/3Co2/3Mn1/3O2 is coated with a conductive Poly (3,4-Ethylene dioxy thiophene)-poly (styrene sulfonate) (PEDOT/PSS) polymer, and their resulting electrochemical properties were investigated as Na-ion battery cathode. The surface-modified Na2/3Co2/3Mn1/3O2 cathode material exhibits a high discharge capacity and good rate capability due to enhanced electron transport by surface PEDOT/PSS. The presence of PEDOT/PSS surface layer suppresses the growth of a resistive layer, while the dissolution of transition metals of the active cathode materials is inhibited as well. The resulting surface-modified Na2/3Co2/3Mn1/3O2 shows superior cycling performance, which is much stable than the pristine one as being the Na-ion battery cathode.
Cytotoxic Triterpenoids from the Stembark of Aglaia argentea (Meliaceae)
Authors: Hidayat Ace Tatang , Farabi Kindi , Harneti Desi , Nurlelasari Nurlelasari , Maharani Rani , Nurfarida Ida , Supratman Unang , Shiono Yoshihito
Published: March 2018

Four dammarane-type triterpenoid compounds, dammar-24-en-3a-ol (1), 3-epi-cabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3b,20-diol (3), and dammar-24-en-3β,20-diol (4), were isolated from the methanolic extract of the stembark of Aglaia argentea. Compounds 1-4 were isolated for first time from this plant. The structure of isolated compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as mass spectrometric analysis. Compounds, 1-4, along with a known synthetic analog, 20-hydroxy-dammar-24-en-3-on (5), were evaluated their cytotoxic activity against P-388 murine leukemia cells in vitro. The IC50 values of compounds, 1-5 were 9.09 ± 0.10, 68.53 ± 0.08, 5.89 ± 0.08, 22.40 ± 0.11, and 11.53 ± 0.08 µg/mL, respectively. Among the dammarane-type triterpenoids, compounds 1, 3, 4 and 5 having opened side chain showed the stronger activity, wheres compound 2 with cyclic side chain showed weak or no activity. In addition, compound 3 showed strongest activity, indicate that hydroperoxy group at side chain increase cytotoxic activity.
The Effect of Pseudomonas aeruginosa Addition on 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) Biodegradation by Brown-rot Fungus Fomitopsis pinicola
Authors: Sariwati Atmira , Purnomo Adi Setyo
Published: March 2018

Effect of addition of Pseudomonas aeruginosa on 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) biodegradation by Fomitopsis pinicola had been investigated. P. aeruginosa was added into F. pinicola culture at 1, 3, 5, 7 and 10 mL (1 mL ≈ 1.53 x 109 P. aeruginosa bacteria cells/mL culture). The addition of 10 mL of P. aeruginosa showed the highest DDT biodegradation approximately 68% during 7 days incubation in Potato Dextrose Broth (PDB) medium, which was higher than biodegradation of DDT by F. pinicola only (42%) at the same incubation time. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (DDD), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) and 1-chloro-2,2-bis(4-chlorophenyl)ethylene (DDMU) were detected as metabolites from DDT biodegradation by mixed cultures of F. pinicola and P. aeruginosa.
Density Functional Theory (DFT) and Natural Bond Orbital (NBO) Analysis of Intermolecular Hydrogen Bond Interaction in "Phosphorylated Nata De Coco - Water"
Authors: Rahmawati Sitti , Radiman Cynthia Linaya , Martoprawiro Muhamad Abdulkadir
Published: March 2018

This study aims to study the conformation, the hydrogen bond network, and the stabilities of all the possible intermolecular interactions in phosphorylated nata de coco membrane with water (NDCF-(H2O)n, n = 1-5). Analysis of natural bond orbital (NBO) was performed to measure the relative strength of the hydrogen bonding interactions, charge transfer, particularly the interactions of n-σ * O-H and to take into account the effect on the stabilities of the molecular structure. All calculation were performed using density functional theory (DFT) method, at B3LYP functional level of theory and 6-311 G** basis set. The charge transfer between the lone pair of a proton acceptor to the anti-bonding orbital of the proton donor provides the substantial to the stabilization of the hydrogen bonds. Interaction between NDCF and (H2O)5 was strongest with the stabilization energy of 37.73 kcal/mol, that indicate the ease of donating lone pair electrons. The contributions of each hydrogen bond to the stability of the complex have been analyzed.
Structure-Activity Relationship Study on the Ethyl p-Methoxycinnamate as an Anti-Inflammatory Agent
Authors: Komala Ismiarni , Supandi Supandi , Nurhasni Nurhasni , Betha Ofa Suzanti , Putri Eka , Mufidah Syarifatul , Awaludin Muhammad Fikry , Fahmi Mida , Reza Muhammad , Indriyani Nurkhayati Putri
Published: March 2018

Ethyl p-methoxycinnamate (EPMC) (1) has been isolated as a major compound from the rhizome of Kaempferia galanga together with the other compound ethyl cinnamate (2). As reported in the literature, EPMC (1) exhibited a significant in vitro and in vivo anti-inflammatory activity. In this research, we investigated the anti-inflammatory activity of compounds 1 and 2 by using anti-denaturation of heat bovine serum albumin (BSA) method. In order to analyze active sites that are responsible for the anti-inflammatory activity, therefore, it is necessary to conduct structural modification of EPMC (1). The structural modification was performed through re-esterification reaction by using conventional and assistance of the unmodified microwave oven. Evaluation of the results of the bioassay indicated that the ester and methoxy functional groups of EPMC (1) play an important role for the anti-inflammatory activity.
Molecular Docking Analysis of Ginger Active Compound on Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1)
Authors: Fajrin Fifteen Aprila , Nugroho Agung Endro , Susilowati Rina , Nurrochmad Arief
Published: March 2018

Ginger had been reported to ameliorate painful diabetic neuropathy (PDN) in an animal model. Gingerol and shogaol were active compounds of ginger that potentially act on transient receptor potential cation channel subfamily V member 1 (TRPV1), a key receptor in PDN. This study aims to predict the binding of gingerol and shogaol to TRPV1 using an in silico model. The ligands of the docking study were 3 chemical compounds of each gingerol and shogaol, i.e. 6-shogaol, 8-shogaol, 10-shogaol, 6-gingerol, 8 gingerol and 10-gingerol. Capsaicin, a TRPV1 agonist, was used as a native ligand. The TRPV1 structure was taken from Protein Data Bank (ID 3J9J). The docking analysis was performed using Autodock Vina. The result showed that among the ginger active compounds, 6-shogaol had the strongest binding energy (-7.10 kcal/mol) to TRPV1. The 6-shogaol lacked the potential hydrogen bond to Ile265 of TRPV1 protein, which capsacin had. However, it's binding energy towards TRPV1 was not significantly different compared to capsaicin. Therefore, 6-shogaol had potential to be developed as a treatment for PDN.
Applying Remote Sensing Technology and Geographic Information System in Batu, East Java
Authors: Hartono Rudi , Nasikh Nasikh
Published: March 2018

This research is aimed to map potential landslide areas, identify types of the landslide, and draw a map of potential landslide level. This research was carried out in Batu, East Java. The research design that was used in the study was image interpretation of Landsat 7 Band 432 Satellite and primary data of the landslide causes (the data of soil and rocks, map interpretation, and variable scoring of the landslide. ArcGIS 9.3 and ArcView 3.2 software was used for map analysis. The researcher also analyzed the soil texture, permeability and land plasticity index, bedding, weathering level, the density of joints, the depth of weathering, the existence of springs, slopes, and slope cutting. The research findings showed that the image of Landsat 7 Bands 432 in 1:11.000 – 1:15.000 scale could be used to interpret land use and land cover. Interpreted land use included housing, bare soil, irrigated rice field, rain-fed rice field, moor, nursery area, garden, slope failure, natural forest, sengon forest, pine forest, and agroforestry.
Aspiration in Basque
Authors: Hualde José Ignacio
Published: March 2018

The distribution of aspiration in Basque — with ‘aspiration’ referring to both the occurrence of [h] and of aspirated stops — shows some puzzling aspects. In some words, aspiration is ancient, in the sense that it must be assumed for the earliest reconstructable stage. In some other instances, however, it has arisen seemingly ex nihilo, as can be observed in borrowings from Latin and Romance, e.g. Latin/Romance īra > Basque hira ‘ire’, Romance taula > Basque thaula ‘board’. Most surprisingly, in some words aspiration has developed after a sonorant consonant, e.g. Romance solatz > Basque solhas ‘conversation’. Aspiration may also continue intervocalic /n/, e.g. Latin anāte > Basque ahate ‘duck’. Another unusual development is the phonologization of the contrast between aspirated and unaspirated voiceless stops triggered by a shift of the stress in some words without affecting the properties of consonants. Finally, an interdialectal alternation /k-/ ~ /g-/ ~ /h-/ ~ Ø in demonstratives and related adverbs appears to have involved fortition, contrary to initial expectations. Here we describe the environments in which aspiration is found in Basque and discuss the most likely historical developments that could have given rise to the state of affairs that we find, paying particular attention to what would appear to be unusual or unnatural sound changes. We build on prior scholarship, but this paper also contains some new hypotheses, especially regarding the aspiration in words like ahate ‘duck’.  We have also tried to contribute to the dating of the different processes and to the understanding of in their causes.
¿Leer para estar bien?: prácticas actuales y perspectivas sobre la biblioterapia como estrategia educativo-terapéutica
Authors: Castro Santana Anaclara , Altamirano Bustamante Nelly
Published: March 2018

La biblioterapia, una tendencia con raíces ancestrales, ha cobrado un nuevo auge mundial en tiempos recientes. Esta propuesta de intervención educativo-terapéutica plantea que es posible mejorar la salud por medio del contacto habitual con la lectura. Partiendo del entendido de que los actos significativos de lectura propician cambios en los individuos, los teóricos y practicantes de la biblioterapia argumentan que leer puede aumentar el bienestar de las personas en diversos contextos y etapas de sus vidas, en especial cuando se hace de manera guiada y propositiva. En este artículo se presenta una revisión de los conceptos y facetas actuales de esta práctica interdisciplinaria, seguida de una exploración sobre sus posibilidades de estudio y aplicación a futuro.AbstractBiblio-therapy, an age-old technique, has recently regained some momentum in diverse settings around the world. This therapeutic-didactic approach posits that one can regain or improve health by reading on a regular basis. Taking this as a point of departure, the idea that significant acts of reading elicit changes in the reader, theorists and active practitioners of bibliotherapy argue that books can improve the well-being of individuals, particularly when it is guided in some way. This paper offers an assessment of concepts and current trends in biblio-therapy as an interdisciplinary practice, along with an exploration of potential paths for further development.