bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of life and psychological well-being of the working population during the lockdown and work-from-home phases of the COVID-19 pandemic
Authors: Jayanand Kalidas , Kannan Radhika , Thottath Deepu , Madayil Drisya
Published: August 2022

Background: The COVID-19 pandemic has shocked the world with lockdown and quarantine procedures and working from home has brought an expeditious change in the daily life of people. The objective of this study was to assess the quality of life of working population during the lock down and work-from-home phases of the second wave of COVID-19 outbreak in Kerala.Methods: A cross-sectional study was done during June to July 2021 among 216 subjects who were employed and had work-from-home during the previous six months. A structured and pre-validated questionnaire including the 36-item short form quality of life (SF-36) was broadcasted through online platforms using google forms. The data was then analysed using the SPSS V.21.Results: The mean age of the study group was 37.8±10.1 years. Most of the subjects belonged to the educational sector 57 (26.4%) and IT sector 48 (22.2%). Bodily pain had the highest domain score (73.55±24.5). When compared to other scores, the mean physical functioning score (58.73±27.9), role limitation due to physical (54.86±37.1), and emotional difficulties (55.19±43.1) had lower scores. All domain scores were found to be higher for people over the age of 60. There was statistically significance between the mean values of social functioning (p=0.010), mental health (p=0.0001), role limitation due to emotional problem (p=0.003), vitality (p=0.0001) and general health (p=0.012) when compared with age groups.Conclusions: There was significant impairment in the quality of life and psychological aspects of the working population of Kerala during the work-from-home phase of the second wave of COVID-19 pandemic.
Validity of anthropometric measurements for estimation of obesity among geriatric residing in Bhavnagar city Gujarat, Western India
Authors: Trivedi Bansi Janak , Trivedi Atul V.
Published: August 2022

Background: Validity of anthropometric measurements has not been adequately evaluated in diverse geriatric population. We determine diagnostic accuracy of body mass index using different anthropometric in assessing the obesity in geriatrics.Methods: This community based cross sectional study was carried out in Bhavnagar city among geriatric people (≥60) residing in 13 different wards of Bhavnagar city during September 2019 to September 2020. Anthropometric data (height, weight, mid upper arm circumference, waist circumference, hip circumference, and skinfold thickness) were measured. Prevalence of obesity measure by different method was compared using kappa coefficient, sensitivity, and specificity.Results: Fair agreement found between waist circumference and BMI for obesity. High sensitivity and low specificity found for BMI measurements at the cut off 30 kg/m2 in comparison of other anthropometric measurements.Conclusions: Body mass index can be used for screening of obesity among geriatrics. however, body mass index should not be used to replace the other anthropometric measurements.
An epidemiological study of nicotine de-addiction
Authors: Desai Muskaan V. , Patel Ritul R. , Sachdeva Punam D.
Published: August 2022

Background: Nicotine is the primary contributor to cancer among users and harms nearly every organ in the body. Nicotine de-addiction is one of the best things that can protect the vulnerable body from disease. Nicotine de-addiction includes diverse methods from simple medical advice to pharmacotherapy. However, some people show serious withdrawal symptoms after quitting. It is therefore necessary to analyze the frequency of the use of various de-addiction methods and prevalence of withdrawal symptoms observed on quitting.Methods: The relevant information was collected from the community (friends, relatives, neighbours, students) using a specially designed Google form or data collection form, prepared in both English and Gujarati. Data collected was subjected to descriptive statistical analysis to determine the frequency distribution of various parameters using Microsoft excel.Results: 83.52% people were aware about the carcinogenic effects of nicotine containing tobacco products. 49.43% people attempted to quit using methods like nicotine replacement therapies, counselling and drug therapy. Out of which, 36.78% people were successful. It was observed that 75.86% people observed one or other withdrawal effects during the quitting attempt.Conclusions: Encouraging users for de-addiction can have positive cascading effects. De-addiction treatments in compliance with people are counselling, Nicotine patches and Nicotine gum. However, many people did not choose any of these methods may be due to cost and access barriers. Integration of nicotine replacement therapies and behavioural treatment must be recommended by the physicians to help their patients overcome this habit.
Knowledge, attitude and perception on breast cancer awareness among paramedical workers
Authors: P. Akila , Esther Blessy , Ambekar Rahul
Published: August 2022

Background: The projected incidence of patients with cancer in India among females was 712,758 (103.6 per 100,000) for the year 2020. 1 in 29 females will develop cancer during their lifetime (0-74 years of age).Methods: This is a descriptive cross-sectional study conducted using a self-administered questionnaire distributed among 392 Registered nurses in a community care hospital. Totally 130 nursing staffs gave consent and were eligible for the study having work experience of more than one year.Results: Total 83 (63%) of study participants belonged to 21-30 years. 113 (86%) thinks breast cancer is a public health problem. 80 (61.5%) thinks breast lump is a most common sign of breast cancer. 121 (93.07%) heard of breast self-examination and 126 (96.9%) thinks it is a useful tool for early detection of breast cancer. 82 (63.07%) said BSE should be done monthly. 114 (87.6%) has been taught how to do BSE. We found 113 (86.9%) has got satisfactory score and average score is 4.67. P value 0.44 when scores of people with breast cancer in their families are compared to people without a positive family history.Conclusions: Based on the results of this study, it was discovered that the low levels of practise were closely related to the lack of awareness of breast cancer screening and the willing to practise breast self-examination. An Indian woman disregards clinical breast examination. By creating awareness, we can reduce the occurrence and death rates from this illness.
Effect of Shiva Samkalpa Sooktha chanting on stress among ayurveda college students: an open label randomized trial design
Authors: A. Resmy Raj , M. Abhilash , Gawande Chitra M. , Kulkarni Jeevan Jagadeesh
Published: August 2022

Backgrounds: Stress is physical or mental tension in response to life demands. In medical sectors, the surplus stress may decrease the students’ abilities to establish good relationships with patients resulting in feeling of clinical dissatisfaction.Methods: In this open label interventional study, 160 students from an Ayurveda college, India who were suffering from moderate stress, after screening with perceived stress scale (PSS 10) were selected. They were instructed to complete the inventory of college student’s recent life experiences (ICSRLE) scale and satva sara assessment. The participants were randomly allocated into two groups of 80 each. Test group was administered shiva samkalpa sooktha chanting continuously for 30 minutes for 48 days at 6 AM in yoga hall of the institution. Control group did not follow any of the practices followed by mantra group. After 48 days; both groups were evaluated for stress and satva sara.Results: Post hoc analysis with Wilcoxon signed rank test showed statistically significant reduction of stress in test group soon after mantra chanting. Mann-Whitney U test showed a difference in perceived stress between groups after mantra chanting; but the result is statistically not significant (U=2446.5, p=0.167). Statistically significant reduction in ICSRLE stress score is observed in test group compared to control group after chanting (U=2268, p=0.040).Conclusions: Short term mantra chanting can reduce the stress among undergraduate students. Reduction is more appreciated in stressors like relationship related problems, time factor and in social isolation factors.
Prevalence of post COVID-19 syndrome
Authors: Shroff Riddhi S. , Talwar Jaspreet Kaur , Ray Manish M.
Published: August 2022

Background: Post COVID-19 syndrome is a condition where symptoms from the acute infection continue to persist after several weeks of testing negative on RT-PCR. It has been divided into 2 stages- post-acute and post chronic COVID-19, where symptoms continue to persist after 3 and 12 weeks respectively. The most common are fatigue, breathlessness, arthralgia, myalgia, chest pain, headache, concentration problems, etc. Different treatment techniques like breathing exercises, strengthening and stretching as well as cardiovascular endurance exercises can be given to improve their quality of life.Methods: A cross-sectional study was conducted among 150 COVID-19 survivors who are in the time-span of more than 3 weeks after testing negative on RT-PCR. A validated questionnaire was circulated via online platforms. The data was analysed using descriptive statistics.Results: Data analysis showed that there was a 39.33% prevalence of post COVID-19 syndrome among the Indian population. The standard deviation of age was 33.96±13.954. It is found that high levels of fatigue (28.2%), myalgia (12.9%), cough (10.3%), headache (7.7%) and breathlessness (7.7%) still exist post 3 weeks of COVID-19 infection. In the case of post 12 weeks of COVID-19 infection, symptoms like fatigue (19%), avascular necrosis of femur (AVN) (12.6%), arthralgia (10.8%), myalgia (9%), problems with concentration (9%) and brain fog (7.2%) still persist.Conclusions: The study confirms the occurrence of long-term COVID-19 effects in the Indian population, and a 39.33% prevalence of post COVID-19 syndrome.
Standard operating procedure for prevention and initial management of COVID-19 in pregnancy at a secondary level hospital in rural South India: a quality improvement project
Authors: Johnson Andrea Daniella , Menezes Gladys
Published: August 2022

Background: During the COVID-19 pandemic there was an influx of antenatal patients presenting with symptoms while still requiring essential obstetric care. We needed to follow a standard operating procedure (SOP) at this rural maternity hospital for the prevention and initial management of COVID-19 in pregnancy.Methods: An SOP was formulated using national and international guidelines that were tailored to a resource-constrained setting. Healthcare workers were trained to implement the SOP. Sequential Plan-Do-Study-Act (PDSA) cycles enabled fine contouring of the prevention and initial management steps. Data was collected using an observational checklist at the end of each PDSA cycle and compared statistically to the baseline assessments using chi-square test.Results: Patients wearing face mask appropriately increased from 60% to 82.4% (P=0.0007). Patients using hand sanitizer provided at the hospital improved from 50% to 84.8% (P=0.0004). Proportion of patients screened for covid-19 symptoms rose from 74% to 94.4% (P=0.0002). Patients counselled for COVID-19 vaccination increased from 42% to 87.2% (P<0.0001). Proportion of patients triaged at the OPD using the SOP improved from 66.6% to 87.2% (P=0.004). All improvements were statistically significant.Conclusions: The SOP for prevention and the initial management of COVID-19 symptoms in pregnancy was successfully implemented followed by PDSA cycles and can be used in similar health-care settings.
Prevalence of anaemia among college going students in India: a systematic review
Authors: Varghese Sheeba , Kareem Semeena N. , Purushothaman Binitha Ponnaparambil , Mukkadan J. K.
Published: August 2022

Anaemia an important global health problem, which is categorized as one of the 10 most serious health problems by the World Health Organization. More than two billion people worldwide are estimated to have anaemia, with majority coming from the developing countries. Anaemia affects health of an individual varying from poor scholastic performance and cognitive impairment and even causes maternal mortalities. Percentage prevalence of anaemia among adolescent girls in the age group 15-19 years and in the older age group 20-29 years remains almost stagnant at 55.8% and 56.1% respectively. Young age period is formative years in life of an individual and crucial period for undertaking greater responsibilities including decision for study, to earn livelihood and healthy responsible parenthood. Protocol of study selection were prepared before the start of study and studies conducted in various states of India among college students and published between the year January 2000 to December 2021 were included. We searched Pubmed, Research gate, Google scholar for articles and 24 studies were included as per predesigned protocol. Analysis of reported studies shown high prevalence of anaemia among college students and more among female students. Subjects of most of the conducted studies were medical students. More studies should be conducted among Arts and Science college students. It is essential to conduct studies among college students to give not only awareness, but also warn them about health hazards and consequences affecting their day to day life.
Human consumption, nutritional value and health benefits of Moringa (Moringa oleifera Lam.): a review
Authors: Hossain M. Farid , Numan Sharker M. , Khan Sayeed Saleh , Mahbub Samiha , Akhtar Shaheen
Published: August 2022

Moringa is an expeditious-growing evergreen perennial plant and has wide adaptability to grow in different environmental conditions. The nutritive value and medicinal benefits of its leaves, flowers, pods, roots, and stem barks are established by philanthropic research. Edible parts are rich in protein, vitamins, minerals, antioxidants, and other chemical compounds with medicinal properties. The pods and leaves are mainly used as vegetables and ingredients in soups and curries. It is used to boost the nutritional value of food, as well as to boost the immune system and antioxidant levels, lower blood sugar levels and maintain inflammation. Moreover, Moringa leaves flavonoid amelioration of total antioxidant capacity in the lens. Its leaves, pods, and leaf powder contain a high proportion of Vitamin A, which can help to prevent night blindness and eye problems in children.
Scientific and Technical Aspects of the Development of the Pulp and Paper Industry in the USSR in the 1950—1980s (Based on Materials from the Leningrad Region)
Authors: Pokidko Pavel
Published: August 2022

The article examines the history of the development of scientific and technical cooperation between enterprises of the pulp and paper industry on the Karelian Isthmus and scientific and technical institutes of the pulp and paper industry. The article examines the problems of reconstruction and modernization of technological processes. The partial nature of the renewal of production equipment and machine tool park is noted, which made it possible to increase volumes, but, at the same time, hindered the expansion of the range of products. On the basis of archival documents of periodicals from the Leningrad Regional State Archives (LOGAV), the Central City Archives of St. the introduction of new technologies in the period under review was the cooperation of industrial enterprises with research organizations.
Philosophical Freethinking in the USSR (Cases of Evald Ilyenkov and Merab Mamardashvili)
Authors: Mikhel Dmitriy
Published: August 2022

The article deals with the phenomenon of philosophical freethinking in the USSR. It is shown that the emergence of freethinking was the result of many years of ideological and political control over philosophical discourse from the early 1930s to the early 1950s. For the generation that chose philosophy as their profession in the 1950s, the main manifestation of freethinking was the creative appeal to the philosophical heritage of Karl Marx, accompanied by attempts to separate the “genuine Marx” from other classics of the Marxist-Leninist philosophical doctrine and to find in Marx’s philosophy the key to understanding modern problems. A remarkable case of philosophical freethinking in the 1950—1970s was the romantic Marxism of Evald Ilyenkov, who was characterized by the desire to protect communist ideals and preserve Marxist dialectics in the face of the threat of the spreading influence of Western philosophy. Another example of freethinking was the philosophical work of Merab Mamardashvili. He began with the development of a Marxist philosophy of consciousness, thanks to which he managed to achieve professional recognition and intellectual independence, but later moved away from the philosophy of Marx and turned to understanding the work of other Western thinkers. The thinking of Descartes, Kant, and Proust for him symbolized a different philosophical homeland and ideals, which in the 1980s he was opposed to Soviet reality and Russian culture.
“Russie Regno Polonie Perpetuo Inscripsit”: Narrative of Substantiation for Historical Rights to East Slavic Lands in the Polish Chronography of 15th — 16th Century
Authors: Karnaukhov Dmitriy
Published: August 2022

The article demonstrated the processes of mythologizing and “political appropriation” of history on the example of pro-scientific historical concepts of Polish authors who substantiated the annexation of southwestern Rus’ to Poland. These concepts are narrative practices that clearly show the possibilities of historiography as an instrument of ideological support of practical policy and a factor in the formation of national cultural and historical mythologemes that had a significant impact on the formation of national identity. By the example of the approaches of several Polish historians to the coverage of Polish-Russian relations, the continuity of the axiological dominants of the national historiography of Poland at the pro-scientific and scientific stages of its development is shown.
On the Fontanka River by the Obukhov Bridge: Economic Activities of the Russian Academy in the 1780s — 1790s
Authors: Gruzdeva Elena
Published: August 2022

The entire history of the St. Petersburg Imperial Russian Academy (1783—1841), being relatively short, can be divided into two periods: the first, which took place on the Fontanka embankment, and the second — on Vasilievsky Island. The article deals with the first period of this institution’s activity associated with the names of Catherine II, E. R. Dashkova, Paul I. However, the research does not focus on publishing the first dictionary of the Russian language or other scholarly works of academicians who already have a rich bibliography, but on the events of economic nature. The article traces the Academy's initial search for temporary premises, followed by acquiring its own real estate; it analyzes the financial side of its existence — budget and off-budget income — ways to increase capital, construction activities and dealing with renters. The author also examines the events which resulted in the loss of the entire economic complex created by the Russian Academy on the Fontanka embankment. The main sources of the research were archival documents: minutes of the Russian Academy’s meetings, account books, business correspondence.
On the Early Period in the Biography of Ieremia Ioffe: upon the Archival Materials
Authors: Ananiev Vitaliy
Published: August 2022

The article is devoted to the reconstruction of the early period of the biography of the prominent Soviet historian of culture and art Ieremia Isaevich Ioffe. Based on the materials of several personal files of Ioffe, preserved in the funds of the Central State Archive of St. Petersburg and the Central State Archive of Historical and Political Documents of St. Petersburg, the author specifies the circumstances of the place and time of Ioffe's birth, and the education he received. The author makes the main emphasis in the article for the period after Ioffe's arrival in Petrograd in 1917. The materials introduced into scientific usage for the first time make it possible to correct ideas about his student years. The importance of his acquaintance with V. A. Desnitsky is stated. The circumstances of Ioffe's studies at the Pedagogical institute named after A. I. Herzen and work at the Communist University named after Zinoviev are described. The environment in which the formation of his theoretical views took place is analyzed.
Expeditionary Activity of Aleksey Pozdneev (1851—1920) with the Reference to the History of the Development of Scientific Mongolian Studies in Russia
Authors: Polyanskaya Oksana
Published: August 2022

The article deals with the expeditionary work of an outstanding Russian specialist in Mongolian studies Aleksey Matveyevich Pozdneev. He can be characterized by a wide range of work, from collecting field materials, compilation of manuscripts in oriental languages and objects of the religious cult of Buddhists to the creation of fundamental works in the history of the development of scientific Mongolian studies and the organization of leading centers for practical Mongolian studies in Russia, whose tasks were to train specialists in the modern East. The author of the article gives details of the scientist's expeditionary activities, revealed both from his published works and manuscripts from the archives of scientific institutions of St. Petersburg as well as shows the importance of scientific trips in general for the formation and development of scientific Mongolian studies in Russia and obtaining objective knowledge about the Mongolian peoples of Inner Asia.Multiple scientific trips to the territory of Mongolia and China, to the nomad camps of the Trans-Baikal Buryats and Kalmyks of the Astrakhan steppes of Russia contributed to the formation of A. M. Pozdneev as an authoritative scholar of Mongolian studies. Knowledge of history, culture, language and experience accumulated during a long stay among the Mongolian peoples determined the direction of his work as a state and public figure who made decisions about organization of education in national schools and conducted surveys on the situation and role of Buddhist Church. He thoroughly collected materials about life and religion, the administrative structure and social structure of Mongolian society in the late 19th — early 20th centuries which allowed to create a comprehensive picture of Mongolia at that time. The richest collections of manuscripts and woodcuts, which make up “A. M. Pozdneev Fund” of the scientific library in St. Petersburg University, contributed to the formation of new directions in Mongolian studies - linguistic, comparative-historical.
Science and Ideology at the Turn of the 1930—1940s: towards the Reconstruction of the Scientific Biography of Vasily Struve
Authors: Bukharin Mikhail
Published: August 2022

The article is devoted to the reconstruction of the scientific biography of Vasily Struve at the turn of the 1930—1940s, which can be regarded as reflection of the general evolution of historical science in the USSR. Struve played an important role in the development of scientific policy in the USSR in the 1930s, he substantiated a number of important theses that determined the attitude of the authorities not only to historical science in particular, but also to science in general in the USSR. Struve himself sought to show loyalty to the teachings of the classics of Marxism-Leninism of the Soviet edition, but it was namely in this aspect that he failed. As Struve’s speech at the discussion of volume II of World History in 1940 shows, he was inclined to fidelity to facts, and not ideological schemes, which he was rather forced to pay tribute to. Nevertheless, Struve was not considered an ally either for the authorities or among the new generation of Marxist scholars who turned the Soviet Marxist scheme of historical progress against Struve himself — one of its authors. The desire to sit on two chairs was one of the factors that did not allow the talent of the Struve-scientist to develop fully, while the efforts of the Struve-administrator to develop scientific policy in the USSR were ultimately in vain.
How it Came to the “Ancient History of the USSR”? Nikolay Marr’s Theory and the Problem of Periodization of Soviet History in the 1930s
Authors: Kirillova Maria
Published: August 2022

The article discusses the background for the appearance in the history of the USSR of “the ancient period” typologically corresponding to the slave-owning formation and directly connected with the subsequent history of the feudal Kievan Rus’. Developing the concept of the history of the USSR in the 1930s was tangibly influenced by the Japhetic theory of Nikolay Marr. The idea of autochthonous ethnic groups made it possible to connect the Slavs and the ancient population of the territory of southern Russia, thus ensuring the unity of the historical process and synchronizing European and Russian history. The conductors of Marr’s influence were the employees of the State Academy of History of Material Culture from the first Marxist generation of historians, primarily Sergey Bykovskiy. An analysis of Bykovskiy’s biography and papers shows that he formulated the idea of the continuity between the Slavic and non-Slavic population even before he began his work with Marr, but after that his constructions became consistently more related with Japhetic theory and more politicized.
Implementation of Digital Ergonomic Tools during the Flexible Screening of Lighting in the Working Environment
Authors: Dupláková Darina , Duplák Ján , Simkulet Vladimír , Kojic Dejan
Published: August 2022

Light is an integral part of our environment. Its effect on humans is significant - it affects not only their visual performance or well-being but also other extra-visual functions of the body, which affect the quality of their life. Lack of light causes various health problems of physiological or psychological dimensions caused by visual discomfort at the workplace. The presented article describes the possibilities of assessing the visual well-being of the workplace by implementing digital ergonomic tools during the flexible screening of lighting. The introductory part of the article is focused on a theoretical description of the issues in the field and then the tools of digital ergonomics are introduced, through which the experiment is carried out. The main part of the article provides an overview of the achieved results and describes the conclusions based on the analysis. Regarding the achieved results, at the end of the article, there is a description of the possibilities of ensuring rationalization measures and the direction of further research.
Genomic Basis of Defining Heterotic Pools in Pigeonpea (Cajanus cajan L.): A Review
Authors: Patel Kishan , Varshney Rajeev , Saxena Rachit , Singh Pradeep Kumar
Published: August 2022

Hybrid breeding strategy leading to define heterotic pools expedited execution of hybrid technology for amelioration of yield, quality, wide adaptability and resistance to biotic and abiotic stresses. In case of pigeonpea conventional hybrid breeding programme has yielded good dividends, yet it can be further honed up by understanding the genome wide variations in the hybrid parental lines for defining heterotic pools. Also, combining ability basis of defining heterotic pools offer enormous opportunities for pragmatic exploitation of pigeonpea hybrid technology with high yield advantages realized in farmers’ fields.
​Efficacy of Pre and Post-emergence Herbicides for Weed Management in Groundnut
Authors: Naik A.H. Kumar , Naik T. Basavaraj , Nagaraj R. , Madhu G. , Goudra Shivanand
Published: August 2022

Background: Herbicides are used in agriculture to reduce the density of weeds and improve the crop yield. Pendimethalin 30% EC is widely used pre-emergent herbicide to control annual grasses and certain broad leaf weeds; is no longer effective against established weeds like Cyperus and Commelina benghalensis, Acalypha indica and Phyllanthus spp. that are dominant in groundnut crop. Combination of Pendimethalin 30% and Imazethapyr 2% EC is a broad-spectrum herbicide that controls most broadleaf weeds and some annual grasses. The current study aimed to improve the profitability of farmers by effectively and economically by controlling the targeted weeds. Methods: A field experiment was conducted at Zonal Agricultural and Horticultural Research Station (ZAHRS), Babbur Farm, Hiriyur, Karnataka during Kharif 2018, 2019 and 2020, to study the efficacy of pre and post-emergence herbicides for weed management in groundnut. The trial comprised of nine treatments involving two pre-emergence herbicides (Pendimethalin 38.7 CS 1.0 kg/ha PE and Pendimethalin 30 EC+Imazethapyr 2 EC 1.0 kg/ha PE (ready mix)) alone and in combinations with post-emergence herbicides (quizalofop-p-ethyl 50 g/ha at 15-20 DAS (PoE)), along with pre-emergence herbicides super imposed with hand weeding at 30 DAS and compared with two inter cultural operation at 15 and 30 DAS followed by manual weeding for intra rows and weedy check. Result: The experimental results revealed that, among the different herbicides treatments, the higher net return (Rs. 92,835/ha) and B:C ratio (2.70) were noticed in Pendimethalin 30 EC+Imazethapyr 2 EC 1.0 kg/ha PE (ready mix)+manual weeding at 30 DAS as compared to control plot (Rs. 2620/ha and 0.96, respectively) this has effectively controlled most of the weed flora present in the experimental field.
Dünyada son beş yıla ait biyobenzer ilaç çalışmalarının sistematik değerlendirilmesi ve çıktılar
Authors: SONER Burak Cem
Published: August 2022

Amaç: Faz 1 çalışmalar aday ilacın ilk defa insan ile karşılaştığı çalışmalar olması nedeni ile
önemlidir. Ülkemizde yazım tarihi itibari ile 12 adet onaylı Faz 1 merkezi bulunmaktadır. Biyoteknolojik
ilaçlar tüm dünyada başarı göstermelerin yanı sıra çok ciddi bir tedavi maliyetine neden
olabilmektedirler. Patent koruma sürelerinin sonlanması ile biyobenzer ilaçlar aynı pazarda yer bularak hem tedavi maliyetlerinde azalmaya hem de daha fazla kişinin ilacı ulaşabilmesine sonuç vermektedir.

Gereç ve Yöntem: Bu yazıda 01.01.2017-01.06.2022 yıllarında dünyada biyobenzer ilaçlar ile yapılmış olan Faz 1, Faz 1, Faz 1-2 klinik çalışmaların sistematik değerlendirilmesi yapılmıştır. Son 65 aya ait olan bu veriler başvuru sayıları, çalışma süreleri, gönüllü sayıları ve sağlıklı gönüllü sayıları açısından ilişkilendirilerek değerlendirilmiştir.

Bulgular: 01.01.2017-01.06.2022 tarihleri arasında toplamda kayıtlı 87 biyobenzer çalışmasında 7746 gönüllü ile çalışılmıştır. Bu gönüllülerin 4906’sı (%76,08) sağlıklı gönüllülerden oluşmaktadır. Tamamlanmış olan çalışmaların ortalama süresi 293,2 gün ve bu çalışmalara ait ortalama gönüllü sayısı 155,6’dır.

Sonuç: Sonuç olarak, biyobenzer ürünler ile yapılan karşılaştırmalı Faz 1 çalışmalar yüksek sayıda sağlıklı gönüllü katılımı gerektirebilen, uzun süreli, her basamağının detaylı olarak planlanması gereken çalışmalardır. Patent sürelerinin sonlanması önümüzdeki dönemde biyobenzer çalışmaları için yeni merkezlerin aranması ihtiyacını doğuracaktır.
Isolation and Enzymatic Degradation of Hemicellulose from Corncobs Waste
Authors: Fithri Lailatul , Damayanti Mamik , Ayu Anna Kartika
Published: August 2022

Corncobs are rich in hemicellulose, which has very important applications in the food industry and biofuels. Hemicellulose is a heteropolysacharide which contains hexosan such as glucan, mannan, galactan and pentosan such as xylan and arabinan. The aims of this research are determining the optimum condition of hemicellulose isolation and identifying enzymatic degradation products of hemicellulose. Hemicellulose is extracted from corn cobs using various NaOH concentrations and extraction times. Acetic acid was added to the mixture after hemicellulose A reflux process, whereas hemicellulose B was precipitated with ethanol 96%. Enzymatic hydrolysis is carried out using xylanolytic enzyme from a recombinant of E. coli DH5α. The yield of hemicellulose is nearly 64.74% (w/w) using NaOH 4 M for 2 h of extraction time. Based on High Performance Liquid Chromatography data indicating that the enzymatic hydrolysis products of hemicellulose A are xylose and arabinose. While xylose, arabinose, and xylooligosaccharide are hemicellulose B and unextracted hemicellulose hydrolysis products.
In Silico Design Gene Encoding CYP71AV1 for Expression in Escherichia coli
Authors: Ulfa Evi Umayah
Published: August 2022

Cytochrome P450 monooxygenase (CYP71AV1) is a crucial enzyme in the artemisinin biosynthesis pathway. This enzyme oxidized Amorpha 4,11 diene to produce artemisinic acid. This study aimed to in silico design high-level expression of CYP71AV1 in the E.coli system. In silico techniques are highly suitable for designing protein recombinant production before entering the laboratory. The amino acid sequence of CYP71AV1 was back-translated to the DNA sequence and adapt to E.coli codon usage by using Gene Designer. The DNA sequence of optimized CYP71AV1 was analyzed using Rare Codon Analysis to assess the expression efficiency in E.coli. The protein solubility prediction was determined using the SoDoPe tool. The optimized CYP71AV1 was determined to have a CAI 0.81, a GC content of 53.08 %, CFD with low frequency, and no negative cis or repeat elements. The result of the probability of solubility of CYP71AV1 was 0.6207 when expressed in E.coli. The MBP fusion partner can be used to increase the solubility of CYP71AV1. The in silico results showed the possibility of high-level protein expression of optimized CYP71AV1 in the E.coli system.
Isolation and Characterization of Uricase Produced from Chicken Liver
Authors: Wuryanti Handayani  , Nasrul Amaliyatun Naja  , Muhamad Kiki Afindia Joenata  , Ratnadewi Anak Agung Istri
Published: August 2022

Uricase is an enzyme that degrades uric acid into allantoin. One of the uricase sources is obtained from chicken species (Gallus gallus domesticus) liver which are broiler and native chicken. This study aims to determine the maximum uricase activity in broiler and native chicken liver. The uricase activity was obtained by measuring the uric acid concentration as uricase substrate using spectrophotometric method and wavelength at 291 nm. Uricase isolation was carried out into extraction process, ammonium sulfate fractionation (0-60% saturation of ammonium sulfate), and dialysis. During isolation process, centrifugation speed was also optimized to obtain the maximum uricase crude extract and uricase activity. The molecular weight of uricase was also determined by SDS PAGE. The result showed that the highest uricase activity remained using centrifugation speed of 15,000 rpm. The optimum uricase fraction for broiler chicken liver was obtained at 20-40% saturation of ammonium sulfate with uricase activity was 1.854 x 10-2 U/mg, and the uricase fraction for native chicken liver was obtained at 40-60% saturation of ammonium sulfate with uricase activity was 2.496 x 10-2 U/mg. The optimum fraction for uricase production and isolation is carried out to the dialysis process. The optimum uricase activity of broiler chicken liver crude extract was 4.921 x 10-4 U/mg, the uricase fraction was 3.989 x 10-3 U/mg, and the dialysate was 5.120 x 10-3 U/mg. While the native chicken liver crude extract was 2.980 x 10-4 U/mg, the uricase fraction was1.415 x 10-2 U/mg, and the dialysate was 1.753 x 10-2 U/mg. The molecular weight of the uricase was around 35 kDA according to the SDS PAGE result.
Partial Purification of Thermophilic Pectinase from Local Isolate Anoxybacillus flavithermus TP-01
Authors: Putri Kartika Dwi Asni , Galih Ayhusta Laras  , Ismi Aulia Syafira  , Afaf Baktir
Published: August 2022

Pectinase is an enzyme that can hydrolyze substances of pectin. It has several applications in daily life, for example in juice factories, wine factories, pulp and paper factories, coffee and tea factories that use fermentation. Pectinase consists of pectate lyase, pectin lyase, and polygalacturonase. The aim of this research is to partially purify pectinase protein by ammonium sulfate precipitation and dialysis. A preliminary test of pectinase activity used halo zone analysis. The partial purification was needed to optimize ammonium sulfate and get the optimal condition in 40–90% of the ammonium sulfate composition. Pectinase activity was measured using DNS method, and the concentration of protein was measured using Bradford method. The result of this partial purification of Anoxybacillus flavithermus TP-01 was 70%. Decreasing od pectinase activity was resulted in this research due to the loss of cofactor. Based on the result, it can be concluded that the pectinase from Anoxybacillus flavithermus TP-01 was polygalacturonase.
New Journey Through Young Customer Experience in Omnichannel Context: The Role of Personalization
Authors: Rahmawati Rahmawati , Arifin Rois
Published: August 2022

Objective: This study investigates the relationship between personalization and customer experience, with emotion and cognitive as the components through which the result repeats purchase intention.
Design/Methods/Approach: This study uses purposeful sampling to enroll research participants based on the research objective. A total of 429 respondents met the criteria, and the hypotheses were tested using Smart PLS 3 software with Partial least squares (PLS) structural equation modeling.
Findings: The results of this study confirm that customer experience is a significant attribute of consumer behavior in the omnichannel context. Specifically, the main findings of our research indicate that emotions and cognitive processes are influenced by personalization, a relationship that has been established in the online context. The findings also indicate that the emotional and cognitive components of the customer experience can influence purchase intention.
Originality: Our framework is based on previous research and applies to a new construct with new phenomena.
Practical/Policy implication: Our finding demonstrates that a better customer experience in an omnichannel context has a beneficial effect on repeat purchase intention, indicating that personalization might influence purchasing behavior. In essence, our finding enables companies to understand the linked nature of variables and consequently prioritize marketing initiatives in an omnichannel context.
Indonesia's Cosmetics Industry Attractiveness, Competitiveness and Critical Success Factor Analysis
Authors: Ferdinand Michelle , Ciptono Wakhid Slamet
Published: August 2022

Objective: This research aims to assess attractiveness, identify national competitiveness drivers, and critical success factors of Indonesia's cosmetics industry as Indonesia has an enormous growing market for cosmetics, but the revenue growth has been declining.
Design/Methods/Approach: This research uses quantitative and qualitative data to conduct a descriptive case study. The first step of the analysis is a pre-test using quantitative data gathered through a survey questionnaire to 30 cosmetics industry practitioners to ensure the validity and reliability of the statement used in this research. The second step is an in-depth interview with ten managers in top cosmetics industry firms in Indonesia.
Findings: It is shown that the cosmetics industry attractiveness in Indonesia is medium. Demand and factor conditions are the main driver of industry competitiveness. Strategy, structure, rivalry, and related and supporting industries are the supporting driver of cosmetics industry competitiveness in Indonesia. Finally, product, marketing, and speed are critical success factors in the cosmetics industry in Indonesia.
Originality: A current study of Indonesia's cosmetics industry mostly explained cosmetics market size, share, growth, segments, trend, industry forecast, leading players in the industry and customer behaviour. However, the study of Indonesia's cosmetics competitiveness landscape and industry critical success factor is still limited.
Aspects of Human Capital Management and Employee Job Performance: The Moderation Role of Perceived Organizational Support
Authors: Gebremedhn Abel , Mekonnen Work , Mulusew Wubshet Bekalu
Published: August 2022

Objective: This study examines the aspects of human capital management and its effects on employee job performance and the moderation role of perceived organizational support.
Design/Methods/Approach: This study is structured on a quantitative approach, with stratified and simple random sampling techniques. This study reports the responses of 426 respondents from twelve banking institutions in Addis Ababa, Ethiopia. Exploratory and confirmatory factor analyses were applied to test the factors and verify the factor structure of a set of observed variables. The scales were tested for reliability and validity. Structural equation modeling with AMOS was used to test the hypothesized relationships.
Findings: The results show that the aspects of human capital management, namely knowledge accessibility, learning capacity, workforce optimization, leadership practice, and career advancement, are positively related to employee job performance. Moreover, the results also reveal that perceived organizational support positively moderates the relationship between knowledge accessibility, learning capacity, leadership practice, career advancement, and employee job performance. Conversely, it is shown that perceived organizational support has an insignificant moderation effect on the relationship between workforce optimization and employee job performance
Originality: Our research highlights the importance of focusing on the intangible assets of an organization (i.e., human capital). Besides, this study contributes to creating a new theoretical framework for the relationship between the aspects of HCM, perceived organizational support, and employee job performance by integrating crucial factors that have not been previously connected.
Combination of Financial Knowledge and Financial Attitude in Establishing Good Financial Management Behaviour for Students After the COVID-19 Pandemic
Authors: Yudha Aji , Pradana Azka
Published: August 2022

Objective: This study aims to investigate the factors influencing student financial management behaviour after the COVID-19 pandemic. Financial management behaviour is believed to be a driving factor in managing good finances during a difficult financial condition.
Design/Methods/Approach: This study applied quantitative methods by distributing questionnaires using google forms. A total of 173 data were declared valid. The data was then processed using SEM GSCA Pro software to test its validity and reliability. Then measurements of the fit model and hypothesis test were carried out. The mediation test was carried out using the Sobel test.
Findings: The results of this study indicate that financial knowledge and financial attitude have a significant effect on financial management behaviour. However, locus of control and materialism do not influence financial management behaviour. This study also revealed that financial attitude mediates the effect of financial knowledge on financial management behaviour.
Originality: This research applied the Theory of Planned Behaviour in predicting factors that influence student financial management. This research also contributes to financial literacy and reveals the influence of financial knowledge, financial attitude, locus of control, and materialism. The difference between this research and the previous one is that this study tried to discuss the antecedents of student financial management behaviour after the COVID-19 pandemic. Financial management behaviour research after the COVID-19 pandemic is rarely examined, so this research filled the existing gaps.
Practical/Policy implication: Practitioners and policymakers should focus on good financial education, so students have good financial knowledge. In addition, inner attitudes must also be formed with periodic training to form a good financial attitude.
Partial double-pruning after bloom delays bunch rot epidemics in Vitis vinifera L. cvs. Riesling and Pinot gris
Authors: Molitor Daniel , Schultz Mareike , Dam Doriane , Pallez-Barthel Marine , Friedel Matthias , Beyer Marco
Published: August 2022

Bunch rot caused by Botrytis cinerea is a major fungal disease in grapevines. Under humid climatic conditions, bunch rot development on grapes cannot be completely suppressed and bunch rot control strategies mainly aim to delay the epidemic. In the present study, we investigated the potential of the innovative cultural practice “partial double-pruning after bloom (PDP)” to delay the bunch rot epidemic on Pinot gris and Riesling cultivars over five consecutive seasons (2016-2020) in Remich/Luxembourg. Control vines were pruned at winter to one 10-node fruiting cane per vine, while in PDP, two 10-node fruiting canes per vine were kept; one of the two canes was removed at BBCH 73 (2-3 weeks after bloom).In all the 10 cultivar*year combinations, the bunch rot disease severity at the final assessment date (shortly before harvest) was lower in PDP than in the control. This reduction was significant (P £ 0.05) in 7 of the 10 cultivar*year combinations. PDP significantly delayed the date when 5 % disease severity was reached; in data pooled over the five years this delay ranged between 10.3 (Pinot gris) and 8.3 days (Riesling). The proportion of non-marketable fruit was significantly reduced by 41 % (Pinot gris) and 53 % (Riesling). Total yield per plant was reduced by 10 % (Pinot gris) and 19 % (Riesling), with a significant increase in total soluble solids at harvest in the case of Riesling. An additional evaluation in the year 2020 revealed reduced cluster compactness in PDP for both cultivars.PDP turned out to be an innovative, efficient, reliable and relatively cost-efficient cultural practice to delay the bunch rot epidemic in grapes. It can be integrated as one module into the best practice strategy to control bunch rot and contributes to pesticide reduction in viticulture.
Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells induce Oxygen-dependent Cell Invasion
Authors: Pachane Bianca Cruz , Nunes Ana Carolina Caetano , Cataldi Thais Regiani , Micocci Kelli Cristina , Moreira Bianca Caruso , Labate Carlos Alberto , Selistre-de-Araujo Heloisa Sobreiro , Altei Wanessa Fernanda
Published: August 2022

Hypoxia, a condition of low oxygenation frequently found in triple-negative breast tumors (TNBC), promotes extracellular vesicle (EV) secretion and favors cell invasion, a complex process in which cell morphology is altered, dynamic focal adhesion spots are created, and ECM is re-modeled. Here, we investigated the invasive properties triggered by TNBC-derived hypoxic small EV (SEVh) in vitro in cells cultured under hypoxic and normoxic conditions, using pheno-typical and proteomic approaches. SEVh characterization demonstrated increased protein abundance and diversity over normoxic SEV (SEVn), with enrichment in pro-invasive pathways. In normoxic cells, SEVh promotes invasive behavior through pro-migratory morphology, in-vadopodia development, ECM degradation and matrix metalloprotease (MMP) secretion. Pro-teome profiling of normoxic cells exposed to SEVh determined enrichment in metabolic processes and cell cycle, modulating cell health to escape apoptotic pathways. In hypoxia, SEVh was re-sponsible for proteolytic and catabolic pathway inducement, interfering with integrin availabil-ity and gelatinase expression. Overall, our results demonstrate the importance of hypoxic signal-ing via SEV in tumors for the early establishment of metastasis.