bluuebunny/crossref_metadata_2025 huggingface dataset:
An Introduction to The Buddhist Cultural Values and Social Life of Himachali People in India
Authors: Dhammajoti Beligalle
Published: August 2022

Himachal Pradesh is a Northern State of India and bears particular types of geographical, cultural and social characteristics. Nowhere in the world that we find this type of cultural and strange social milieu. Geographically, it is a mountainous area with thousands of dangerous precipices with scenic splendour with many of the Himalaya snow-capped mountains. From mountain to mountain, from province-to-province narrow roads are present and they are extremely unsafe.  Environmentally it is the most suitable place for man to lead a happy and healthy life. People are fortunate enough to breathe fresh air and use pure water. Their religious and cultural values are of a unique character and the social life can also be considered to be peaceful and exemplary in nature. Buddhist monasteries in the Himalayan region have been having a profound impact on the cultural and social life of the people for centuries. Some of the aspects of Buddhist cultural values remain unnoticed. This paper tries to prove that there is exceptionality in Himachal culture and its social life. The objective of this research is to show the peculiarity of the Himachal life style to the rest of the world. The research method used in this research work is a qualitative research method based on observed empirical information, and secondary documents are also used.
English Functions and Ideologies in Newspaper Editorials
Authors: Gnanaseelan Jeyaseelan
Published: August 2022

Language functions empower media in 'knowledge management.' It reveals the media construction of policies, nations, peoples, communities, and individuals. Scholars have developed critical discourse analytical tools for this purpose. First, they show the theoretical constructs to approach texts for these purposes. Second, they investigate 'language in use and language in a social context.' According to experts, the CDA analysis will probe language organisation and linguistic units; a text is studied in contexts and with co-texts at both micro and macro-levels of the genre as linguistic and social practices. It is tied to social relations and identities, power, inequality, and social struggle. Thus, this paper undertakes a case study of The Hindu Editorial, 'Beyond the admission imbroglio,' published on Friday the 4th of May, 2007. It investigates how language is utilised by the media to establish or change the existing knowledge base for the empowerment of interested parties or to control the access to knowledge and resources by the underprivileged communities. Therefore, this paper attempts to identify linguistic structures and strategies such as semantic moves, nominalization, passivisation and topicalisation, used in media discourse to communicate visible or latent ideologies and attitudes in discourse construction and consumption. The text projects dichotomy and binary positions using functional English, discursive and linguistic construction reinforcing the relationship between corporate power and ideology, and naturalised group-based cultural and exclusive nationalism cloaked by constitutional and inclusive nationalism. The media discourse is oriented towards legitimisation, political accommodation, and ideological management.
Factors Influence on Studеnts’ Intention of the Continuous Usage of the Lеаrning Management System (LMS)
Authors: Muthugаmаgе C. D. , Gаlhеnа B. L.
Published: August 2022

When considering higher education in Sri Lanka, technology received a high demand in most situations due to the passage of time and the conversion of teaching and learning methods into education. Mοrеοvеr, in thе contemporary wοrld, thеrе is а trend fοr using Lеаrning Management Systеms (LMS), which еnhаncе lеаrning online. Sri Lаnkа is аn emergent nation that is fаr diffеrеnt from dеvеlοpеd cοuntriеs in thе cοntеxt οf tеchnοlοgy, еcοnοmy, аnd the еnvirοnmеnt. In οrdеr tο rеcеivе thе bеnеfits of invеsting in thе LMS, thе studеnt's intеntiοn tο cοntinuοus usаgе οf the LMS is mοrе criticаl. Though a significаnt numbеr οf studеnts rеgistеrеd with thе LMS, thе аctivе studеnts аrе mаrginаlly аt а lοw lеvеl in certain educational institutes. The continuous usage of the LMS is relatively low among professional students. Though the student intention to use the LMS has been explored largely, the intention of continuous usage of the LMS is largely unexplored in the developing context. Thus, thеrе is а compelling nееd tο lеаrn аbοut whаt fаctοrs аffеct thе intеntiοn tο the cοntinuοus usаgе οf the LMS by studеnts аs οrgаnizаtiοns invеst lаrgеly in implеmеnting аnd mаintаining thе LMS. Thus, thе purpοsе οf this study is tο discοvеr thе fаctοrs аffеcting prοfеssiοnаl studеnts' intеntiοn tο the cοntinuοus usаgе of the LMS with special reference to the Nаtiοnаl Institutе οf Businеss Mаnаgеmеnt. Following a survey of the existing literature, the independent variables were identified. A survey questionnaire was distributed to professional undergraduates of the National Institute of Business Management, and 250 responses were gathered. Multiplе Rеgrеssiοn аnаlysis wаs pеrfοrmеd tο tеst thе fοur hypοthеsеs which wеrе dеvеlοpеd in this study. The findings rеvеаlеd thаt the pеrcеivеd еаsе οf usе, the pеrcеivеd usеfulnеss, sеlf-еfficаcy, аnd the quаlity οf the LMS аrе significаnt fаctοrs dеtеrmining thе intеntiοn for the continuous usаgе οf the LMS. This study is important for several stakeholders, such as administrators and vendors, as the findings of the study contribute to making certain strategic and policy decisions in ensuring the continuous active use of e-learning platforms such as the LMS. The present study contributes to the existing knowledge as the study explains an unexplored phenomenon of the continuous usage of the LMS in developing country contexts focusing on professional students.
Evaluation of Endophytic Fungal Extracts of Mucuna pruriens for the Presence of L-Dopa
Authors: Sivaladchanam Yalini , Liyanaarachchie Chamila P.T.
Published: August 2022

Background: Mucuna pruriens (Fabaceae) is a natural source of levodopa (L-Dopa). Urbanization and overexploitation have made the plant scarce. Thus, investigations for alternative sources for natural L-Dopa are important. This study aimed to investigate the capability of the endophytic fungi present in M. pruriens plant for the production of L-Dopa.Methods: Compounds of air-dried plant parts were extracted with methanol. Endophytic fungi in fresh plant parts were isolated and grown to obtain metabolites. Plant extracts and the endophytic fungal metabolites were analyzed for the presence of L-Dopa with respect to the standard using thin-layer chromatography.Results: Nine endophytic fungi were isolated from different plant parts. Seed and pod extracts and their endophytic fungal metabolites contained L-Dopa.Conclusion: M. pruriens associated endophytic fungi could be excellent sources of natural L-Dopa.
Evaluation of Patient Related Factors, the Level of Glycemic Control; and Cost of Diabetic Medications of Patients Attending Selected Public Sector Diabetic Clinics in Sri Lanka
Authors: Miriyagalla Buddhini D. , Liyanaarachchie Chamila P.T.
Published: August 2022

Background: Diabetes Mellitus (DM) is a global epidemic. Globally the number of diabetic complications is increasing. Therefore, it is important to find the reasons for the escalating number of diabetic complications and associated mortality. The main objective of this study was to evaluate patients’ knowledge and level of adherence to treatments, the cost associated with diabetic medications and the level of glycemic control.Methods: This study was a pretested, structured questionnaire-based cross-sectional survey with retrospective data collection from participants’ clinic books. The questionnaire was developed to obtain data on socio-demographic variables; patients’ knowledge on disease and medicines; patients’ dietary control and adherence to the medications and non-medicinal recommendations.Results: Patients (n = 207) attending the diabetes clinics of two teaching- and two base-hospitals in Sri Lanka were taken as the sample. The majority of the participants demonstrated moderate knowledge (63%) on DM. Of the participants, 46% had moderate adherence to pharmacological and nonpharmacological recommendations of healthcare providers and 55% showed good glycemic control. The monthly average drug cost for a DM patient was 270.10 Sri Lankan Rupees (LKR). There was a significant association between participants’ knowledge and level of adherence. However, there were no significant associations between participants’ knowledge and glycemic control, or patients’ adherence and glycemic control. There was a significant knowledge gap between the patients attending Teaching- and Base-hospitals.Conclusion: The majority of the diabetic patients had either moderate or above knowledge and adherence, but their glycemic control was sub-optimal and associated with factors other than patients’ knowledge and adherence.
Effects of Human Milk Oligosaccharides on Microbiome
Authors: Senanayake Udeshika , Bowatte Gayan
Published: August 2022

Human Milk Oligosaccharides (HMOs), the complex, unique glycans present in human milk, are essential for infants’ early development and provide many health benefits to humans. Although the effects of all the individual HMOs are not fully understood, studies have revealed many health benefits of HMOs acting as prebiotics. They shape the gut microbiome, provide immune-modulatory and anti-adhesive effects to enhance innate and acquired immunity in the host and modulate the epithelial barrier. The effects of HMOs are not only limited to the infant gut microbiome but also affect the microbiome of breast milk and adults. This mini review highlights the recent findings on the effects of HMOs on the microbiome. It discusses the benefit of synthesizing and identifying the structures of individual glycans for further improvement in human health.
Molecular Farming: Implication for Future Pharmaceutical Products
Authors: Kumari Sajeewani R. , Tennakoon Imalka
Published: August 2022

The goal of molecular farming is to produce large amounts of active and secure pharmaceutical proteins at a low cost. Nowadays, gene transfer methods in plants have advanced significantly because of scientific advances in the field of biotechnology. Compared to other microbial and animal expression systems, these transgenic plants have several advantages in terms of ease of production, low cost, safety, and so on for producing pharmaceutical biomolecules. So far, many valuable pharmaceutical proteins and antibodies have been produced using this method, which has significantly aided patient treatment, particularly in developing countries where the production and preservation costs of such medicines are prohibitively expensive. However, there are some disadvantages, such as acceptance by the public, transgene escape and biosecurity, and so on, however, it is hoped that with the efforts of researchers, molecular farming will achieve great success in the near future. This mini-review highlights the history of molecular farming, plant transformation strategies, classes of protein within molecular farming, products in the market, products nearing commercialization, advantages of using transgenic plants as a bioreactor, major barriers to broader market penetration and strategies to overcome them, biosafety and challenges in the production of proteins and future prospects.
Academic Recognition of Systematic Reviews and the Evidence-based Research Approach in Postgraduate Health and Clinical Sciences in Sri Lanka - Can the University of Peradeniya Take the Lead?
Authors: Weerasekara Ishanka , Durage Lamawansa M. , Devane Declan , Lund Hans
Published: August 2022

No abstract available.
Food Security in Sri Lanka During COVID19 Pandemic
Authors: Ekanyake Ramya , Dassanayake Damayanthi
Published: August 2022

No abstract available.
Inhibition of APLN suppresses cell proliferation and migration and promotes cell apoptosis in esophageal cancer cells in vitro, through activating PI3K/mTOR signaling pathway
Authors: Wang Yuhan , Wang Gang , Liu Xiaojun , Yun Dong , Cui Qing , Wu Xiaoting , Lu Wenfeng , Yang Xiwen , Zhang Ming
Published: August 2022

Esophageal cancer is the sixth leading cause of cancer mortalities globally with a high incidence rate. Apelin (APLN) plays regulatory roles in different organs. However, its role in esophageal cancer remains unknown. Therefore, our study aims to explore the effect of APLN on esophageal cancer. One hundred and eighty-four (184) esophageal tumor tissues samples from patients with esophageal cancer, and 11 esophageal tissues samples from healthy volunteers were analyzed for the expression of APLN. APLN was highly expressed in the tumor of patients with esophageal cancer and esophageal cancer cells.  Patients with high expressions of APLN had a lower survival rate than the ones with low to medium expressions of APLN.  Human esophageal carcinoma cell lines, TE-1 and ECA-109 cells were transfected with APLN siRNA to knockdown APLN, or transfected with pcDNA-APLN to overexpress APLN. Inhibition of APLN by siRNA-APLN reduced proliferative, migrative, and invasive abilities of esophageal cancer cells and promoted cell apoptosis, which could be all restored by pcDNA-APLN. Moreover, knocking down APLN by siRNA-APLN suppressed the PI3K/mTOR signaling pathway. These findings identify that APLN inhibition might ameliorate esophageal cancer through activating the PI3K/mTOR signaling pathway, thus APLN could be a potential target for esophageal cancer.
Sleep Disorders in Patients with Parkinson's Disease during COVID-19 Pandemic
Authors: Desai Ishita , Gupta Ravi , Kumar Mritunjai , Tiwari Ashutosh , Kumar Niraj
Published: August 2022

Objective:

To assess the impact of coronavirus disease 2019 (COVID-19) pandemic on sleep disorders among Parkinson's disease (PD) patients using validated questionnaires.

Materials and Methods:

This prospective study involved 50 PD patients and 50 age, gender, and body mass index-matched controls. All participants underwent assessment of cognition using Montreal Cognitive Assessment scale, sleep quality using Parkinson's disease sleep scale-2 (PDSS-2; for PD patients) and Pittsburgh Sleep Quality Index (PSQI; for PD patients and healthy controls), excessive daytime sleepiness (EDS) using Epworth sleepiness scale (ESS), insomnia symptoms and severity using insomnia severity index (ISI), restless legs syndrome (RLS) using International RLS Study Group criteria, rapid eye movement sleep behavior disorder (RBD) using RBD Single-Question Screen (RBD1Q), and depression using Patient Health Questionnaire-9 scale.

Results:

Eighty-eight percent of PD patients reported one or more sleep disorders, compared to 28% controls. While 72% of PD patients reported poor sleep quality (PDSS-2 ≥15, PSQI >5), 60% had insomnia, 58% reported RBD, 50% had EDS, and 36% reported RLS. Depressive symptoms were reported by 70% patients. PD patients with and without poor sleep quality were comparable with regards to demographic and clinical variables, except for depressive symptoms (P < 0.001). Depressive symptoms showed a significant association with EDS (P = 0.008), RBD (P < 0.001), and insomnia (P = 0.001).

Conclusion:

Prevalence of sleep disorders increased in PD patients during the COVID-19 pandemic. Prevalence of EDS, RBD, and RLS in PD patients was higher compared to that reported in studies during the pre-COVID-19 times. Presence of depressive symptoms was a significant correlate of presence of sleep disorders in PD patients.
The Spectrum of Neuro-COVID
Authors: Vengalil Seena , Mahale Rohan , Chakradhar N. , Alluri Swathi , Sagar Navanith PR , VH Ganaraja , Haripriya KR , Vikram Holla Venkappayya , Asranna Ajay , Mailankody Pooja , Seshagiri Doniparthi V , Cheerla H Manoj , Maturu VN , Vaddepally CR , Kenchaiah Raghavendra , PR Srijithesh , Chaudhuri Jaydip Ray , M Netravathi , Alladi Suvarna
Published: August 2022

Background:

Though reports of neurological manifestations of COVID-19 have emerged from various parts of the world, the cohorts reported are from the West and mostly derived from electronic databases. Much remains unknown regarding neuro-COVID in developing countries. India is the second-worst affected country, and this study reports the neurological manifestations of COVID-19 in a comprehensively evaluated cohort.

Objective:

The aim of this study was to describe the range of neurological manifestations of COVID-19 in India with an emphasis on the risk factors, laboratory and imaging findings and short-term outcome.

Methods:

Retrospective review of hospital records of all confirmed COVID-19 patients with neurological manifestations, receiving inpatient care in two neurology referral hospitals were done. All demographic, clinical details, investigations, and treatment were analysed.

Results:

A total of 120 confirmed COVID-19 cases presenting with neurological symptoms were included. The mean age of illness and duration of illness was 48.03 ± 17.3 years and 10.9 ± 17.3 days respectively. New onset of neurological symptoms occurred in 100 cases while 20 patients had worsening of pre-existing neurological illness. Stroke was the commonest neurological disorder (43%), followed by encephalopathy (23%) and Guillain-Barre syndrome (10%). Other unusual neurological manifestations included new-onset headache (7%), seizures including denovo status epilepticus (5%) and meningo-encephalitis (5%). Nearly half of the patients had preceding COVID-19 symptoms. Poor outcome at discharge was seen in 40% and mortality occurred in 15%.

Conclusion:

Stroke and encephalopathy constitute the most common neurological manifestations. The absence of preceding COVID-19 symptoms in nearly half the cases is striking. Poor outcome was seen in nearly 50% despite early recognition and management.
Demystifying the Relevance of Size Amongst Macro- and Micro-Corticotropinoma
Authors: Gupta Rahul , Jain Nimisha , Bhansali Anil , Bhadada Sanjay K. , Walia Rama
Published: August 2022

Objective:

In individuals with adrenocorticotrophic hormone (ACTH)-dependent Cushing’s syndrome (CS), to estimate the differences between micro-corticotropinoma (size ≤6 mm and 6-10 mm), macro-corticotropinoma (>10 mm) and ectopic Cushing’s syndrome (ECS), in relation to their epidemiological, clinical and biochemical parameters.

Methods:

In individuals with CS, the clinical and hormonal parameters, and magnetic resonance imaging of sella were collected from 1984 to 2019. A total of 138 cases of micro-corticotropinoma, 47 cases of macro-corticotropinoma and 21 cases of ECS were compared.

Results:

Except for size, there were no differences in biochemical and hormonal parameters of macro- and micro-corticotropinoma, irrespective of their size (≤6 mm, 6-10 mm and >10 mm). In comparison to Cushing’s disease (CD), individuals with ECS had a male predominance (F:M ratio of 2.4:1 vs. 0.5:1), shorter duration from onset of symptoms to diagnosis (24 vs. 12 months). They also had a higher ACTH (139 vs. 65.8 pg/ml), 0800h cortisol (1200 vs. 880 nmol/l), 2300h cortisol (1100 vs. 700 nmol/l) and cortisol levels after high dose dexamethasone suppression test (1050 vs. 244.5 nmol/l).

Conclusion:

The biochemical phenotype of macro-corticotropinoma resembles that of micro-corticotropinoma despite their larger tumour size, suggesting that the former is relatively less functional. Micro-corticotropinoma ≤6 mm and 6-10 mm have a similar clinical and biochemical profile. As compare to CD, ECS is characterised by a higher disease burden as reflected in their higher cortisol, more autonomicity and loss of rhythmicity.
The Twenty First Century E- Learning Education Management & Implication for Media Technology Adoption in the Period of Pandemic
Authors: Matthew Ugochukwu O. , Kazaure Jazuli S. , Kazaure Ado Saleh , Onyedibe Ogechukwu N. , Okafor Abraham N.
Published: August 2022

INTRODUCTION:  The relevance of multimedia electronic learning(e-learning) education in the ongoing COVID-19 pandemic in the developing nations are justifiable on the pedagogical connections between the twenty first century digital automation and education itself. Multimedia is a creative combination of computer hardware , software and lifeware that allows for integration of video, animation, audio, graphical information and text resources in an interactive engagement , in which information are accessed interactively with any information processing devices.
OBJECTIVES: To enable personalizable and autonomous learning accomplishments when multimedia educational tools are merged , which allows for diversity in curriculum presentation.
METHODS: The current research investigated 400 postgraduate students of faculty of computer science and information technology who adopted the multimedia e-learning education approach to ensure that the  expected date of graduation was not extended during the recent institution lock .
RESULTS :The research observed that out of six multimedia e-learning education tools  used, e-mail functionalities, chat apps, audio/video computing application and discussion forum were mostly used to provide meaningful interactive engagement  while blogs and webcast were less utilized.
CONCLUSION:  The research proposed an enhanced level electronic participation, electronic readiness and e-learning education framework that matched the standards for the smartest educational reform that will enable regular and consistent educational accomplishment without disruptions of academic workflow in the global  educational business ,notwithstanding the severity of any future pandemic similar to ongoing COVID-19.
Raspberry Pi-based Intelligent Cyber Defense Systems for SMEs and Smart-homes: An Exploratory Study
Authors: Tirumala Sreenivas Sremath , Nepal Narayan , Ray Sayan Kumar
Published: August 2022

Ongoing ransomware attacks have forced business to think about security of their resources. Recently, small- to-medium enterprises (SMEs) and Smart-homes have become easy targets for attackers since they don’t have cyber defense mechanism in place other than simple firewall systems which are quite vulnerable. Cyber defense systems are costly and often not within the budget of SMEs or families which inspired to think about low cost yet highly efficient cyber defense solutions. Regular individuals and families who use internet for day to day use often end-up becoming a possible resource for using them as Trojan or bitcoin nodes. This research explores the prospects of implementing a Raspberry Pi (Raspberry Pi)-based intelligent cyber- defense system (iCDS) for SME networks and Smart-homes to filter malicious contents from incoming traffic and detect malware using artificial intelligence.
Primarily, the work presented in this paper tries to evaluate the hardware capability of network interfaces (both internal, and attached) of Raspberry Pi for handle high volumes of incoming traffic. For this, we measure the network performance of the Raspberry Pi using the speed test software and try to explore the possibility of a light weight machine learning (ML) based malware detection. The results show that the built in Ethernet interface outperforms the built in WiFi and external attached USB to Ethernet Adapter in terms of latency, download and upload throughput. Also, a new DNA based ML approach was successfully able to produce over 19.5% better accuracy rates of over classifier trained with hash-sequence. The experiment results further emphasise on the importance of generating complex malware signatures with variety to face existing threats which has taken a new form due to increase in malware based attacks, particularly for ransomware. The complexity of the generated malware is based on generic yet strong encryption principles which produced good results which is quite encouraging at this stage.
Radiografía de los micro-influencers en la economía de las plataformas digitales: insatisfacción, trabajo gratuito y desigualdad en la retribución
Authors: Villegas-Simón Isabel , Fernández-Rovira Cristina , Giraldo Luque Santiago , Bernardi Alessandro
Published: August 2022

Introducción: Los influencers se han convertido en nuevos prescriptores y trabajadores digitales que construyen comunidades digitales sólidas para los anunciantes. Los microinfluencers (5.000 - 40.000 seguidores) son utilizados por las marcas para impactar en comunidades digitales pequeñas con un alto grado de compromiso. Esta investigación explora la relación entre la inversión de tiempo, el impacto digital y la remuneración económica de la actividad de los microinfluencers para identificar nuevas formas de precariedad laboral en el ámbito digital. Metodología: Se han estudiado 34 microinfluencers a través de dos técnicas: la monitorización de sus perfiles digitales para calcular sus KPI (ej. engagement y EMV), y a través de un cuestionario destinado a conocer su satisfacción, tiempo invertido y remuneración económica. Además, se ha realizado un segundo estudio sobre la actividad digital de 21 influencers celebridades. Resultados y discusión: El análisis de los datos indica que los microinfluencers están insatisfechos debido a tres factores: la relación entre el tiempo invertido y la remuneración económica, la necesidad de crear publicaciones sin generar ingresos y la desproporcionada relación entre el tamaño de su comunidad, el vínculo que producen con sus seguidores y los beneficios en comparación con las celebridades influencers. Conclusiones: Las conclusiones contribuyen a la literatura precedente sobre la falsa meritocracia del éxito en redes sociales y confirman la retribución a través de visibilidad y capital social a costa de la precariedad de las condiciones laborales dentro de una economía liderada por las plataformas digitales.
Design and Development of an Escape Game as a Knowledge Transfer Tool in Preparation for an Accreditation Visit in a Health Care Facility
Authors: Chabrier Amélie , Difabrizio Aurélia , Parisien Geneviève , Atkinson Suzanne , Bussières Jean-François
Published: August 2022

Background: Knowledge transfer helps health care staff to be competent, well informed, and up to date. It also contributes to adherence to standards and best practices.
Objectives: To design, implement, and evaluate an escape game based on a selection of Accreditation Canada required organizational practices (ROPs).
Methods: This prospective descriptive study involved nurses and pharmacists in a health care centre. An escape game based on 6 ROPs was designed. The game was played by teams of participants in a patient room within the centre, with each game lasting 25 minutes. Participants’ satisfaction with various aspects of their experience was assessed.
Results: A total of 200 people (52 teams) participated in the escape game. About half of the teams (n = 28) completed the game within the allotted time (average completion time 20 minutes, 53 seconds; standard deviation [SD] 2 minutes, 45 seconds). On average, 1.32 (SD 0.88) clues were provided to successful teams and 1.88 (SD 0.95) to unsuccessful teams. Participants were very satisfied with their experience. However, members of unsuccessful teams had significantly lower agreement that the escape game was relevant to their practice and that it was an effective method of communication.
Conclusions: An escape game based on a selection of ROPs was successfully implemented as part of the hospital’s preparation for an accreditation visit. Use of an escape game as a knowledge transfer tool was appreciated by the staff.
Эквивариантные пополнения аффинных пространств
Authors: Arzhantsev Ivan , Zaitseva Yulia Ivanovna
Published: August 2022

Работа содержит обзор недавних результатов об открытых вложениях аффинного пространства $\mathbb{C}^n$ в полные алгебраические многообразия $X$, для которых действие векторной группы $\mathbb{G}_a^n$ на $\mathbb{C}^n$ параллельными переносами продолжается до действия $\mathbb{G}_a^n$ на $X$. В первой части работы мы подробно изучаем соответствие Хассетта-Чинкеля, описывающее эквивариантные вложения $\mathbb{C}^n$ в проективные пространства, и приводим его обобщение на случай вложений в проективные гиперповерхности. Последующие разделы посвящены изучению вложений в многообразия флагов и в их вырождения, в полные торические многообразия и в многообразия Фано определeнных типов.
Библиография: 109 названий.
Исчисление Шуберта и теория пересечений многообразий флагов
Authors: Duan Haibao , Zhao Xuezhi
Published: August 2022

В 15-й проблеме Гильберта была поставлена задача строгого обоснования исчисления Шуберта; сложной частью такого обоснования является давняя проблема характеристик Шуберта. В ходе создания основ алгебраической геометрии Ван дер Варден и А. Вейль отнесли эту проблему к теории пересечений для многообразий флагов.
В статье рассматриваются предыстория, содержание и решение проблемы характеристик. Нашими основными результатами являются единая формула для характеристик и систематическое описание колец пересечений многообразий флагов. Эффективность формулы и алгоритма проиллюстированы на явных примерах.
Библиография: 71 название.
Zoning Analysis of Iron Age Sites Using Analytic Hierarchical Process (AHP) Methods in the Middle Atrak River Basin, Northeast of Iran
Authors: Heydari Dastenaei Mohsen , Dana Mohsen
Published: August 2022

Iron Age settlements in the Middle Atrak Basin in Iran have a particular distribution pattern due to environmental, social, and economic variables, among which geographical factors play an essential role in creating and dispersing settlements. Some of these factors play a more effective and stable role than others. The present study examines and evaluates the role of geographical factors in the distribution of Iron Age sites to determine factors that have a more significant role than others. Moreover, the zoning map of the Middle Atrak Basin should be presented using four different types of location, grouped in terms of those with a perfectly suitable, relatively suitable, suitable, and unsuitable location. To achieve this goal, seven natural factors, including the distance of sites from the river, altitude, slope, slope direction, distance from communication routes, soil type, and land use, were selected as influential factors in choosing the location of the Iron Age sites. In this study operating maps were prepared digitally using ArcGIS, and then the weight of each index was determined using the AHP model. The results of this study show that 46.7% of the Iron Age settlements (or 28 sites) were located in a perfectly suitable environment and geography, 24 sites (29.3%) in a relatively suitable location, seven sites (11.4%) in a suitable place, and one site (1.6%) in a completely unsuitable environment. This last type of location in the region’s landscape indicates the choice of different livelihoods, including agriculture and animal husbandry with both seasonal and permanent methods.
Estimation of Curie-Point Depths and Heat Flow from Spectral Analysis of EMAG2 Magnetic Data in Cyprus Island
Authors: Pamuk Eren , Özsöz İlkin
Published: August 2022

This study aims to determine Curie point depth (CPD), Heat flow and the boundaries of geological structures of Cyprus Island using EMAG2 magnetic data. CPD values were calculated by applying spectral analysis technique to magnetic anomaly map divided into 60 blocks (60x60 km2). Then, different thermal conductivity values (K=1, 1.5 and 2.5 Wm–1 K–1) and heat flow values were calculated using CPD values.  CPD values ranged from 12.4 km to 28.18 km, and heat flow values were calculated between 20 and 50 mW/m2 for K=1.  Shallow CPD values (CPD< 15km) were calculated in Polis, Morphou Bay, in the area between Larnaca and Famagusta and north of Kyrenia. Heat flow values are relatively high in these areas which can be researched in detail in terms of potential geothermal. In the final phase of the study, the boundaries of buried geological structures were determined by Analytic Signal (AS), Total Horizontal Derivative (THDR) and Tilt angle (TA) methods. Moho depth, Curie-Moho difference, 2D cross-correlation map of Moho and Curie depths and Earthquake distribution map are used for interpretation of the tectonic regime. Moho-Curie difference is roughly 0 and the 2D cross-correlation map produces higher (0.60-0.75) values in the southern part of the study area which might be evaluated as a passive crust. It is possible to say that few earthquakes are observed where the difference is around 0.
Concentration of anti-inflammatory cytokines in supernatants of peripheral blood cell cultures in children with autoimmune and infectious diseases
Authors: Krivolapova Irina M. , Pashnina Irina A.
Published: August 2022

Cytokines belong to the class of signaling molecules, being involved into regulation of proliferation, differentiation and effector functions of immunocompetent cells. The ratio of pro- and anti-inflammatory cytokines is important for development of any inflammatory process. IL-1ra, IL-4, IL-10 are among the most important anti-inflammatory cytokines. Their function is to limit and suppress immune response in inflammatory processes of any etiology. In this respect, the aim of this study was to evaluate production of the anti-inflammatory cytokines IL-1ra, IL-4 and IL-10 by peripheral blood cells in children with autoimmune and infectious diseases. Patients and methods: Pediatric parients (2-17 years old) participated in the study including those with juvenile idiopathic arthritis (n = 101); unspecified reactive arthropathy (n = 24); systemic lupus erythematosus (SLE, n = 14); chronic viral hepatitis C (n = 24). 33 healthy children (n = 33) comprised the control group. Heparinized blood samples were diluted with glutamine-containing medium RPMI-1640. Control samples were not treated by any stimulants, and the stimulated samples were supplied with phytohemagglutinin (20 mkg/ml). The samples of diluted blood were incubated for 24 hours (37 C, 5% CO2). The supernates were frozen once. The concentrations of IL-1ra, IL-4 and IL-10 in these cell supernatants were determined by ELISA technique (Vector-Best, Russia). Results: It was found that the spontaneous production of anti-inflammatory cytokines (IL-1ra, IL-4 and IL-10) didnt differ, or was lower in the groups of patients with SLE, juvenile idiopathic arthritis and hepatitis C if compared with control group. SLE is an autoimmune disease, whereas juvenile arthritis is of mixed autoimmune-autoinflammatory etiology. Chronic hepatitis C is a viral disease, but autoimmune responses may manifest at the chronic stage of the disorder. Decreased production of anti-inflammatory cytokines could be an evidence for autoimmune mechanisms of these diseases, despite their different etiology. More intensive spontaneous production of IL-1ra and IL-10 in children with unspecified reactive arthropathy may suggest some compensatory reactions which inhibit development of inflammation in this disorder. IL-1ra, IL-4 and IL-10 production in stimulated cultures didnt differ between all groups of the patients, or it was lower in comparison with healthy children. Decrease cytokine production in groups of children with different diseases suggests exhausted functional reserve of immunocompetent cells caused by their chronic activation.
Reduction determinants of Scots pine tree-ring width in the vicinity of Puławy industrial plants (central-eastern Poland)
Authors: Kalbarczyk Robert , Ziemiańska Monika , Kalbarczyk Eliza , Nieróbca Anna , Dobrzańska Joanna
Published: August 2022

Scots pine (Pinus sylvestris L.) is a tree species that reacts to meteorological conditions, industrial pollution and groundwater level. The aims of this study were to evaluate reductions and increases in Scots pine tree-ring widths (VTRW) as compared to reference sequences for sites in two types of forest habitat found in the vicinity of the chemical plant complex in Puławy, located in central-eastern Poland, and to determine the relationship between VTRW, climate and anthropogenic factors. A considerable reduction in tree-ring widths compared with reference sites was found for sites affected by chemical plant emissions from the end of the 1960s, i.e. right after the start of the Puławy industrial plants, to the beginning of the 1990s (implementation of new technologies). This period of reduction in tree-ring width lasted longer and was greater in magnitude in the pure Scots pine stands studied within a coniferous mixed forest habitat. Furthermore, the reduction in Scots pine tree-ring width was largely dependent on below-average air temperature in the period from December of the year preceding ring formation until January of the current year and above-average total precipitation from June until August above-average SO2, NH3 and NOx emissions and above-average surface and underground water withdrawals from company intakes. The influence of weather on VTRW was weakened by anthropogenic factors, which affected the quality of the local natural environment. Therefore, Scots pine tree-ring width may be used to evaluate the state of the natural environment and threats it is facing in areas with high levels of industrial pollution including, for example, SO2, NH3 and NOx. Keywords: temperature and precipitation conditions, air pollution, tree-ring width, forest research area, dendroecological studies, Central Europe, Pinus sylvestris L.
Сhallenges for scientific and pedagogical staff of universities after pandemia 2019
Authors: Melnyk Nataliia , Stepanova Tеtiana , Sytchenko Anatolii , Zaplatynska Anna , Korniienko Iryna
Published: August 2022

Nowadays situation at the universities in Ukraine and all other countries round the world are faceted with different challenges almost every new quarter of the year. The very vivid example of it was the pandemic period, which determined transforming of forms of education and different approaches to education. Moreover, the Pandemia provoke the huge wave of challenges for scientific and pedagogical staff of universities. A great number of changes took place at the system of educational process organization: pandemic has exacerbated the need for digital, technology-enabled education experiences, new types of online-classes appared and new ways to scale them etc. But after pandemic period and all these transmitions in universities their appared the need for analyses of challenges which we are going to face with, when we come back to ordinary style of teaching? what problems are we going to solve? To answer these questions, we created a Questionnaire for teaching staff and students of different Universities in Ukraine in different regions. We asked them to give their feedbacks, opinions and feelings of the quarantine restrictions of COVID-19, what difficulties they had durining the next few months. The investigation helped to distinguish challenges to scientific and pedagogical staff of higher educational institutions, the nature of which is the peculiarities of the professional activities of teachers and challenges to the scientific and pedagogical staff of higher educational institutions, the nature of which are the features of the educational activities of students.
Gamification of education: innovative forms of teaching and education in culture and art
Authors: Pishchanska Viktoriia , Altukhova Anna , Prusak Yurii , Kovmir Nataliia , Honcharov Andrii
Published: August 2022

The article is devoted to the analysis of the concept of "gamification of education". The study aimed to determine the features of gamification in education and analysis of innovative forms of teaching and development of the educational process in the field of culture and art. Research methods: among the theoretical -analysis, synthesis and systematization and generalization of scientific and scientific-methodical literature to clarify the state of study of the research problem and specify the concepts on whichthe process is based; among the empirical -questionnaires of participants in the educational process in order to understand the place of the method of "gamification" in the educational process of higher education institutions. The results of the study highlight the features of the phenomenon of "gamification" and its possibilities in the organization of the educational process during the training of future professionals, in particular in the field of culture and art; there are three types of gamification that are used in education (light, deep and combined); the fundamental components of the method (elements, mechanisms, dynamics, game characters)
Upaya Meningkatkan Hasil Belajar Matematika Siswa Melalui Model Problem Based Learning Berbantu Information Communication and Technology
Authors: Pasza Febriah Bella
Published: August 2022

Penelitian Tindakan Kelas (PTK) ini bertujuan untuk meningkatkan hasil belajar matematika siswa melalui model problem based learning berbantu information communication and technology siswa pada siswa kelas VIII E semester genap SMP Negeri 49 Jakarta tahun ajaran 2020-2021. Populasi penelitian berjumlah 34 orang siswa yang seluruhnya diteliti. Penelitian ini dilatarbelakangi oleh rendahnya nilai rata-rata ulangan semester genap sebelum diberikan tindakan dan rendahnya aktivitas siswa saat proses pembelajaran. Berdasarkan hasil pengamatan awal sebelum tindakan rata-rata hasil belajar matematika siswa sebesar 69,471 dengan persentase pencapaian KKM 44,118%. Tes evaluasi pada tindakan siklus pertama diperoleh nilai rata-rata kelas sebesar 77,411 dengan persentase pencapaian kriteria ketuntasan minimal 67,647%. Pada tindakan siklus kedua diperoleh nilai rata-rata kelas sebesar 80,176 dengan persentase pencapaian kriteria ketuntasan minimal 82,353%. Hasil observasi aktivitas siswa pada siklus I mencapai persentase 45,2% dan pada siklus II mengalami peningkatan menjadi 80,6%. Dapat disimpulkan bahwa menggunakan model problem based learning berbantu ICT siswa dapat meningkatkan hasil belajar matematika siswa kelas VIII E semester genap SMP Negeri 49 Jakarta
El plan de marketing como estrategia de posicionamiento en mipymes del sector turismo
Authors: García Román Alberto Quijano , Cortés Roger Manuel Patrón , Chuc Giselle Guillermo , Blum Fernando Medina
Published: August 2022

El caso abordado presenta uno de los problemas generalizados en las mipymes de países emergentes, cuando éstas buscan permanecer en el sector económico, pero requieren que el usuario conozca de su existencia y la calidad de los servicios que puede ofrecer como vía para la generación de ingresos. El estudio incluye aspectos teóricos sobre posicionamiento en el mercado y estrategias de mercadotecnia e importancia económica del sector turístico con un diseño metodológico del caso anidado de tipo ilustrativo pues cuenta con más de una unidad de análisis.  En el análisis particular resaltan el emprendedurismo de los copropietarios así como la combinación de experiencia-profesión aplicadas en la empresa, la planeación de sus proyectos de expansión y el desarrollo de estrategias de crecimiento. Se concluye que la organización estudiada cuenta con fortalezas como su ubicación estratégica y la celebración de convenios con otros prestadores de servicios, pero también se ve amenazada por la globalización que reduce la migración turística ante los problemas económicos que enfrenta regiones como el euromercado.
Sistem Pendukung Keputusan Peserta Lomba Desain Logo Menggunakan Metode Simple Additive Weighting (SAW) Berbasis Website
Authors: Habibur Rahman Arjuni  , Arif Senja Fitrani
Published: August 2022

The Faculty of Business, Law and Social Sciences (FBHIS) Universitas Muhammadiyah Sidoarjo (Umsida) held an FBHIS Logo Design Competition for the FBHIS creative community. The provisions of the competition are to represent all study programs (Prodi) in FBHIS, namely Management Study Program, Master of Management, Law, Communication Studies, Public Administration, Accounting, and Digital Business. To help determine the winner of the best contestants, a decision support system (SPK) is needed that is able to provide alternative solutions to the parties concerned. The method used in the decision support system for selecting participants in the logo design competition uses the Simple Additive Weighting (SAW) method for the weighting of the criteria. The software used in making DSS is MySQL and PHP. The assessment criteria are taken from the Originality selection test scores, Design Idea Concepts, Aesthetic Values, Conformity of Themes and Messages Delivered. Alternative samples were taken as many as 20 participants with the top rank. The results of the SAW calculation give the order of the participants' scores from the highest to the lowest. The result of the SPK is not a final decision, because it goes back to the one who made the decision
Covid Impact on Tourism Profit and Cash Holding
Authors: Wijaya Anggita Langgeng , Hasanah Karuniawati , Sari Linda Puspita
Published: August 2022

The Covid-19 pandemic has significantly impacted various socio-economic aspects of Indonesian society. Tourism activities are a sector directly affected by the harmful effects of Covid-19. The implementation of restrictions on community activities to overcome the Covid-19 pandemic has made tourism business activities experience financial difficulties, leading to business bankruptcy. This study analyzes local tourism companies' profitability and cash holdings in Umbul, Madiun, and East Java before and during the Covid-19 pandemic. This study uses a descriptive qualitative approach. The research data was obtained through observation, interviews, and analysis of the company's financial data. The results of this study indicate a decrease in profitability and a decrease in cash holdings for local tourism companies in Umbul, Madiun during the Covid-19 pandemic. A decrease in profitability and a decrease in cash holdings can be interpreted as an increase in business risk leading to financial difficulties. Local tourism companies Umbul Madiun are advised to focus on the company's cash conversion cycle, more conservative accounting and business policies, and focus on activities that directly impact the number of tourist visits. This strategy is expected to increase the company's profitability, the efficiency of cash holdings management, and efforts to revive the tourism business after the pandemic conditions at the local tourism company Umbul Madiun.
Manufacturing Companies :The Effect of Liquidity and Corporate Governance on Financial Performance with Firm Size as a Moderating
Authors: Dyana Novita Taristy  , Ulil Hartono  , Nadia Asandimitra Haryono
Published: August 2022

Financial performance is important to see the level of achievement of predetermined targets, as material for evaluation, and policies that must be taken by management. The influence of liquidity and good corporate governance through the mechanism of ownership structure towards the financial performance of Manufacture Company listed on the IDX in 2020-2021 with firm size as moderating variable are the aim of this research. This type of research is quantitative research with secondary data. The purposive sampling method was used for research sampling and obtained 87 companies. Moderate regression analysis (MRA) is used to be analysis technique in this research. This research get results that liquidity has a significant positive effect on financial performance, but institutional and managerial ownership have not effect on financial performance because companies whose ownership structure is dominated by institutional investors actually get a poor response from the market and the company's managerial shareholding has not been able to align the interests of shareholders outside of management, and then firm size can’t moderate the relationship of liquidity, institutional and managerial ownership to financial performance because the size of the company is not so much noticed by interested parties in the company.