bluuebunny/crossref_metadata_2025 huggingface dataset:
Diabetic Vasculopathy: Molecular Mechanisms and Clinical Insights
Authors: Jia George , Bai Hetty , Mather Bethany , Hill Michael A. , Jia Guanghong , Sowers James R.
Published: January 2024

Clinical and basic studies have documented that both hyperglycemia and insulin-resistance/hyperinsulinemia not only constitute metabolic disorders contributing to cardiometabolic syndrome, but also predispose to diabetic vasculopathy, which refers to diabetes-mellitus-induced microvascular and macrovascular complications, including retinopathy, neuropathy, atherosclerosis, coronary artery disease, hypertension, and peripheral artery disease. The underlying molecular and cellular mechanisms include inappropriate activation of the renin angiotensin–aldosterone system, mitochondrial dysfunction, excessive oxidative stress, inflammation, dyslipidemia, and thrombosis. These abnormalities collectively promote metabolic disorders and further promote diabetic vasculopathy. Recent evidence has revealed that endothelial progenitor cell dysfunction, gut dysbiosis, and the abnormal release of extracellular vesicles and their carried microRNAs also contribute to the development and progression of diabetic vasculopathy. Therefore, clinical control and treatment of diabetes mellitus, as well as the development of novel therapeutic strategies are crucial in preventing cardiometabolic syndrome and related diabetic vasculopathy. The present review focuses on the relationship between insulin resistance and diabetes mellitus in diabetic vasculopathy and related cardiovascular disease, highlighting epidemiology and clinical characteristics, pathophysiology, and molecular mechanisms, as well as management strategies.
Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
Authors: Park Wonyoung , Han Jung Ho , Wei Shibo , Yang Eun-Sun , Cheon Se-Yun , Bae Sung-Jin , Ryu Dongryeol , Chung Hwan-Suck , Ha Ki-Tae
Published: January 2024

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Targeted therapy against the epidermal growth factor receptor (EGFR) is a promising treatment approach for NSCLC. However, resistance to EGFR tyrosine kinase inhibitors (TKIs) remains a major challenge in its clinical management. EGFR mutation elevates the expression of hypoxia-inducible factor-1 alpha to upregulate the production of glycolytic enzymes, increasing glycolysis and tumor resistance. The inhibition of glycolysis can be a potential strategy for overcoming EGFR-TKI resistance and enhancing the effectiveness of EGFR-TKIs. In this review, we specifically explored the effectiveness of pyruvate dehydrogenase kinase inhibitors and lactate dehydrogenase A inhibitors in combating EGFR-TKI resistance. The aim was to summarize the effects of these natural products in preclinical NSCLC models to provide a comprehensive understanding of the potential therapeutic effects. The study findings suggest that natural products can be promising inhibitors of glycolytic enzymes for the treatment of EGFR-TKI-resistant NSCLC. Further investigations through preclinical and clinical studies are required to validate the efficacy of natural product-based glycolytic inhibitors as innovative therapeutic modalities for NSCLC.
Role of Clay Substrate Molecular Interactions in Some Dairy Technology Applications
Authors: Azzouz Abdelkrim , Arus Vasilica Alisa , Platon Nicoleta
Published: January 2024

The use of clay materials in dairy technology requires a multidisciplinary approach that allows correlating clay efficiency in the targeted application to its interactions with milk components. For profitability reasons, natural clays and clay minerals can be used as low-cost and harmless food-compatible materials for improving key processes such as fermentation and coagulation. Under chemical stability conditions, clay materials can act as adsorbents, since anionic clay minerals such as hydrotalcite already showed effectiveness in the continuous removal of lactic acid via in situ anion exchange during fermentation and ex situ regeneration by ozone. Raw and modified bentonites and smectites have also been used as adsorbents in aflatoxin retention and as acidic species in milk acidification and coagulation. Aflatoxins and organophilic milk components, particularly non-charged caseins around their isoelectric points, are expected to display high affinity towards high silica regions on the clay surface. Here, clay interactions with milk components are key factors that govern adsorption and surface physicochemical processes. Knowledge about these interactions and changes in clay behavior according to the pH and chemical composition of the liquid media and, more importantly, clay chemical stability is an essential requirement for understanding process improvements in dairy technology, both upstream and downstream of milk production. The present paper provides a comprehensive review with deep analysis and synthesis of the main findings of studies in this area. This may be greatly useful for mastering milk processing efficiency and envisaging new prospects in dairy technology.
α-L-Fucosidases from an Alpaca Faeces Metagenome: Characterisation of Hydrolytic and Transfucosylation Potential
Authors: Krupinskaitė Agnė , Stanislauskienė Rūta , Serapinas Pijus , Rutkienė Rasa , Gasparavičiūtė Renata , Meškys Rolandas , Stankevičiūtė Jonita
Published: January 2024

In various life forms, fucose-containing glycans play vital roles in immune recognition, developmental processes, plant immunity, and host-microbe interactions. Together with glucose, galactose, N-acetylglucosamine, and sialic acid, fucose is a significant component of human milk oligosaccharides (HMOs). Fucosylated HMOs benefit infants by acting as prebiotics, preventing pathogen attachment, and potentially protecting against infections, including HIV. Although the need for fucosylated derivatives is clear, their availability is limited. Therefore, synthesis methods for various fucosylated oligosaccharides are explored, employing enzymatic approaches and α-L-fucosidases. This work aimed to characterise α-L-fucosidases identified in an alpaca faeces metagenome. Based on bioinformatic analyses, they were confirmed as members of the GH29A subfamily. The recombinant α-L-fucosidases were expressed in Escherichia coli and showed hydrolytic activity towards p-nitrophenyl-α-L-fucopyranoside and 2′-fucosyllactose. Furthermore, the enzymes’ biochemical properties and kinetic characteristics were also determined. All four α-L-fucosidases could catalyse transfucosylation using a broad diversity of fucosyl acceptor substrates, including lactose, maltotriose, L-serine, and L-threonine. The results contribute insights into the potential use of α-L-fucosidases for synthesising fucosylated amino acids.
Investigation of Clinical Features and Association between Vascular Endothelial Injury Markers and Cytomegalovirus Infection Associated with Thrombotic Microangiopathy in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: Case-Based Research
Authors: Nimura Takayuki , Aomura Daiki , Harada Makoto , Yamaguchi Akinori , Yamaka Kosuke , Nakajima Takero , Tanaka Naoki , Ehara Takashi , Hashimoto Koji , Kamijo Yuji
Published: January 2024

Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) can occasionally trigger thrombotic microangiopathy (TMA). Cytomegalovirus (CMV) may be reactivated during intensive immunosuppressive therapy for AAV and cause TMA. Therefore, we aimed to evaluate the clinical features of and the association between vascular endothelial injury markers and TMA due to CMV in patients with AAV. A 61-year-old female was diagnosed with AAV and severe kidney injury. Immunosuppressive therapy gradually improved her symptoms and laboratory findings. However, 2 weeks after induction therapy initiation, she exhibited altered consciousness, a significant decrease in platelet count, and hemolytic anemia, resulting in a TMA diagnosis. Plasma exchange did not improve TMA findings and routine screening test revealed CMV infection. Ganciclovir injection improved the infection and TMA findings. Consequently, we diagnosed her with CMV-induced TMA. Both AAV and CMV may induce severe vascular endothelial injury, potentially leading to TMA development. CMV-induced TMA should be considered when TMA develops during induction therapy against AAV. Moreover, of the three serum markers of vascular injury—serum sulfatides, soluble thrombomodulin, and pentraxin 3—serum sulfatides may be associated with the development of TMA, and a high level of soluble thrombomodulin may be associated with the development of CMV viremia during the clinical course of AAV.
COVID-19 and Antipsychotic Therapy: Unraveling the Thrombosis Risk
Authors: Dho-Nagy Eszter-Anna , Brassai Attila , Lechsner Patrick , Ureche Corina , Bán Erika-Gyöngyi
Published: January 2024

In the context of the COVID-19 pandemic, this study investigates the potential correlation between the increased use of antipsychotic medications and the rising incidence of venous thromboembolism (VTE). As psychiatric disorders surged, the consequential escalation in antipsychotic drug use raised concerns about thrombotic risks. We conducted a comprehensive literature review using PubMed, focusing on articles that intersected COVID-19, antipsychotic medication, and thrombosis. This approach allowed for a nuanced examination of the historical and recent data on antipsychotic drugs and their association with thrombotic events. Our findings reveal a notable link between the use of antipsychotic medications, particularly second-generation antipsychotics, and an increased risk of VTE, including pulmonary embolism and deep vein thrombosis. This association was evident, despite variations in study designs and populations. The study underscores the need for cautious medication management in psychiatric care, especially during pandemic conditions like COVID-19, to mitigate thrombotic risks. It advocates a personalized approach to prescribing antipsychotics, considering individual patient factors and comorbidities, to balance the benefits against potential thrombotic complications.
Nrf2 Pathway and Oxidative Stress as a Common Target for Treatment of Diabetes and Its Comorbidities
Authors: Yi Michelle , Cruz Cisneros Leslie , Cho Eric J. , Alexander Michael , Kimelman Francesca A. , Swentek Lourdes , Ferrey Antoney , Tantisattamo Ekamol , Ichii Hirohito
Published: January 2024

Diabetes is a chronic disease that induces many comorbidities, including cardiovascular disease, nephropathy, and liver damage. Many mechanisms have been suggested as to how diabetes leads to these comorbidities, of which increased oxidative stress in diabetic patients has been strongly implicated. Limited knowledge of antioxidative antidiabetic drugs and substances that can address diabetic comorbidities through the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway calls for detailed investigation. This review will describe how diabetes increases oxidative stress, the general impact of that oxidative stress, and how oxidative stress primarily contributes to diabetic comorbidities. It will also address how treatments for diabetes, especially focusing on their effects on the Nrf2 antioxidative pathway, have been shown to similarly affect the Nrf2 pathway of the heart, kidney, and liver systems. This review demonstrates that the Nrf2 pathway is a common pathogenic component of diabetes and its associated comorbidities, potentially identifying this pathway as a target to guide future treatments.
Heterologous Expression of Difficult to Produce Proteins in Bacterial Systems
Authors: Ferrer-Miralles Neus , Garcia-Fruitós Elena
Published: January 2024

Proteins play a crucial role in maintaining homeostasis, providing structure, and enabling various functions in biological systems [...]
The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection Responses
Authors: Liu Shuang , Li Zhangcheng , Lan Shimei , Hao Huafang , Baz Ahmed Adel , Yan Xinmin , Gao Pengcheng , Chen Shengli , Chu Yuefeng
Published: January 2024

Transcription factors are pivotal regulators in the cellular life process. Activating transcription factor 3 (ATF3), a member of the ATF/CREB (cAMP response element-binding protein) family, plays a crucial role as cells respond to various stresses and damage. As a transcription factor, ATF3 significantly influences signal transduction regulation, orchestrating a variety of signaling pathways, including apoptosis, ferroptosis, and cellular differentiation. In addition, ATF3 serves as an essential link between inflammation, oxidative stress, and immune responses. This review summarizes the recent advances in research on ATF3 activation and its role in regulating inflammatory responses, cell apoptosis, and ferroptosis while exploring the dual functions of ATF3 in these processes. Additionally, this article discusses the role of ATF3 in diseases related to pathogenic microbial infections. Our review may be helpful to better understand the role of ATF3 in cellular responses and disease progression, thus promoting advancements in clinical treatments for inflammation and oxidative stress-related diseases.
Knockdown of the ABCG23 Gene Disrupts the Development and Lipid Accumulation of Panonychus citri (Acari/Tetranychidae)
Authors: Wang Hongyan , Wang Haifeng , Xin Tianrong , Xia Bin
Published: January 2024

Panonychus citri is a worldwide citrus pest that is currently controlled through the use of insecticides. However, alternative strategies are required to manage P. citri. Recent studies suggest that the ATP-binding cassette (ABC) transporter G subfamily plays a crucial role in transporting cuticular lipids, which are essential for the insect’s barrier function against microbial penetration. Therefore, investigating the potential of the ABC transporter G subfamily as a control measure for P. citri could be a promising approach. Based on the genome database, the gene was cloned, and the transcriptional response of ABCG23 for the different developmental stages of P. citri and under spirobudiclofen stress was investigated. Our results showed that the expression level of ABCG23 was significantly lower in adult females exposed to treatment compared to the control and was higher in females than males. The knockdown of ABCG23 using RNAi led to a decrease in the survival rate, fecundity, and TG contents of P. citri. Additionally, a lethal phenotype was characterized by body wrinkling and darkening. These results indicate that ABCG23 may be involved in cuticular lipid transportation and have adverse effects on the development and reproduction of P. citri, providing insight into the discovery of new targets for pest management based on the insect cuticle’s penetration barrier function.
A Receptor Integrin β1 Promotes Infection of Avian Metapneumovirus Subgroup C by Recognizing a Viral Fusion Protein RSD Motif
Authors: Cui Yongqiu , Li Siting , Xu Weiyin , Li Yeqiu , Xie Jiali , Wang Dedong , Guo Jinshuo , Zhou Jianwei , Feng Xufei , Hou Lei , Liu Jue
Published: January 2024

Avian metapneumovirus subgroup C (aMPV/C) causes respiratory diseases and egg dropping in chickens and turkeys, resulting in severe economic losses to the poultry industry worldwide. Integrin β1 (ITGB1), a transmembrane cell adhesion molecule, is present in various cells and mediates numerous viral infections. Herein, we demonstrate that ITGB1 is essential for aMPV/C infection in cultured DF-1 cells, as evidenced by the inhibition of viral binding by EDTA blockade, Arg-Ser-Asp (RSD) peptide, monoclonal antibody against ITGB1, and ITGB1 short interfering (si) RNA knockdown in cultured DF-1 cells. Simulation of the binding process between the aMPV/C fusion (F) protein and avian-derived ITGB1 using molecular dynamics showed that ITGB1 may be a host factor benefiting aMPV/C attachment or internalization. The transient expression of avian ITGB1-rendered porcine and feline non-permissive cells (DQ cells and CRFK cells, respectively) is susceptible to aMPV/C infection. Kinetic replication of aMPV/C in siRNA-knockdown cells revealed that ITGB1 plays an important role in aMPV/C infection at the early stage (attachment and internalization). aMPV/C was also able to efficiently infect human non-small cell lung cancer (A549) cells. This may be a consequence of the similar structures of both metapneumovirus F protein-specific motifs (RSD for aMPV/C and RGD for human metapneumovirus) recognized by ITGB1. Overexpression of avian-derived ITGB1 and human-derived ITGB1 in A549 cells enhanced aMPV/C infectivity. Taken together, this study demonstrated that ITGB1 acts as an essential receptor for aMPV/C attachment and internalization into host cells, facilitating aMPV/C infection.
Genome-Wide Association Study Identifies Rice Panicle Blast-Resistant Gene Pb4 Encoding a Wall-Associated Kinase
Authors: Fan Yunxin , Ma Lu , Pan Xiaoqian , Tian Pujiang , Wang Wei , Liu Kunquan , Xiong Ziwei , Li Changqing , Wang Zhixue , Wang Jianfei , Zhang Hongsheng , Bao Yongmei
Published: January 2024

Rice blast is one of the most devastating diseases, causing a significant reduction in global rice production. Developing and utilizing resistant varieties has proven to be the most efficient and cost-effective approach to control blasts. However, due to environmental pressure and intense pathogenic selection, resistance has rapidly broken down, and more durable resistance genes are being discovered. In this paper, a novel wall-associated kinase (WAK) gene, Pb4, which confers resistance to rice blast, was identified through a genome-wide association study (GWAS) utilizing 249 rice accessions. Pb4 comprises an N-terminal signal peptide, extracellular GUB domain, EGF domain, EGF-Ca2+ domain, and intracellular Ser/Thr protein kinase domain. The extracellular domain (GUB domain, EGF domain, and EGF-Ca2+ domain) of Pb4 can interact with the extracellular domain of CEBiP. Additionally, its expression is induced by chitin and polygalacturonic acid. Furthermore, transgenic plants overexpressing Pb4 enhance resistance to rice blast. In summary, this study identified a novel rice blast-resistant gene, Pb4, and provides a theoretical basis for understanding the role of WAKs in mediating rice resistance against rice blast disease.
Modulation of Tau Pathology in Alzheimer’s Disease by Dietary Bioactive Compounds
Authors: Shi Huahua , Zhao Yan
Published: January 2024

Tau is a microtubule-associated protein essential for microtubule assembly and stability in neurons. The abnormal intracellular accumulation of tau aggregates is a major characteristic of brains from patients with Alzheimer’s disease (AD) and other tauopathies. In AD, the presence of neurofibrillary tangles (NFTs), which is composed of hyperphosphorylated tau protein, is positively correlated with the severity of the cognitive decline. Evidence suggests that the accumulation and aggregation of tau cause synaptic dysfunction and neuronal degeneration. Thus, the prevention of abnormal tau phosphorylation and elimination of tau aggregates have been proposed as therapeutic strategies for AD. However, currently tau-targeting therapies for AD and other tauopathies are limited. A number of dietary bioactive compounds have been found to modulate the posttranslational modifications of tau, including phosphorylation, small ubiquitin-like modifier (SUMO) mediated modification (SUMOylation) and acetylation, as well as inhibit tau aggregation and/or promote tau degradation. The advantages of using these dietary components over synthetic substances in AD prevention and intervention are their safety and accessibility. This review summarizes the mechanisms leading to tau pathology in AD and highlights the effects of bioactive compounds on the hyperphosphorylation, aggregation and clearance of tau protein. The potential of using these bioactive compounds for AD prevention and intervention is also discussed.
The tgd5 Mutation Affects Plastid Structure and Causes Giant Lipid Droplet Formation in Trichomes of Arabidopsis
Authors: Matsuoka Kanae , Kubotera Hiroko , Miyazaki Rina , Moriyama Shota , Fujiwara Makoto T. , Itoh Ryuuichi D.
Published: January 2024

Trichomes, epidermal protrusions in terrestrial plants, play diverse roles in plant defense, metabolism, and development. Arabidopsis thaliana, a model plant with single-celled and non-glandular trichomes, is a valuable system for studying cell differentiation in plants. However, organelle biology in Arabidopsis trichomes is relatively underexplored. Using light and transmission electron microscopy, we investigated the phenotypes of intracellular structures in Arabidopsis trichomes caused by tgd5 mutations, which are known to disrupt lipid transfer from the endoplasmic reticulum to plastids and have a large impact on chloroplast morphology in pavement and guard cells. Significant phenotypic changes in the plastid structure were observed in tgd5 trichome cells, including the absence of plastoglobuli, the emergence of clusters of electron-dense particles in the stroma, and the possibly cup-shaped morphology of plastids. Additionally, the tgd5 mutations triggered the formation of giant, up to 15 µm in diameter, neutral lipid-containing droplets in the trichome cells, as revealed using histochemical staining with lipophilic dyes. These lipid droplets were substantially larger and more frequent in trichome cells than in other types of cells in tgd5. These findings highlight the role of TGD5 in maintaining plastid structure and implicate the unique activity of lipid metabolism in Arabidopsis trichomes.
Blockchain in Smart Grids: A Bibliometric Analysis and Scientific Mapping Study
Authors: Lampropoulos Georgios
Published: January 2024

To achieve sustainability and fulfill sustainable development goals, the digitalization of the power sector is vital. This study aims to examine how blockchain can be integrated into and enrich smart grids. In total, 10 research questions are explored. Scopus and Web of Science (WoS) were used to identify documents related to the topic. The study involves the analysis of 1041 scientific documents over the period 2015–2022. The related studies are analyzed from different dimensions including descriptive statistics, identification of the most common keywords and most widely used outlets, examination of the annual scientific production, the analysis of the most impactful and productive authors, countries, and affiliations. The advancement of the research focus and the most popular topics are also examined. Additionally, the results are analyzed, the main findings are discussed, open issues and challenges are presented, and suggestions for new research directions are provided. Based on the results, it was evident that blockchain plays a vital role in securing smart grids and realizing power sector digitalization, as well as in achieving sustainability and successfully meeting sustainable development goals.
Low Response Rate to Follow-Up Using Telemedicine after Total Knee Replacement during the COVID-19 Pandemic in Italy
Authors: Cammisa Eugenio , La Verde Matteo , Coliva Federico , Favero Antongiulio , Sassoli Iacopo , Fratini Stefano , Alesi Domenico , Lullini Giada , Zaffagnini Stefano , Marcheggiani Muccioli Giulio Maria
Published: January 2024

Background: This study aimed to evaluate the survival rate and medium-term outcomes of patients after cemented posterior-stabilized (PS) mobile-bearing (MB) total knee arthroplasty (TKA) using a telemedicine platform during the COVID-19 pandemic in Italy. Methods: A total of 100 consecutive patients (mean age 73.5 ± 13.2 years) who received a cemented PS MB TKA were enrolled. The mean age of patients who did not complete the telemedicine follow-up (58%) was 75.8 ± 9.7 years. A dedicated software that makes it possible to perform video calls, online questionnaires, and acquire X-rays remotely was used. Subjective clinical scores and objective range-of-motion (ROM) measurements were observed at an average follow-up of 54 ± 11.3 months. Results: A total of 42 of 100 enrolled patients (mean age 70.3 ± 8.4 years) completed the telemedicine follow-up. The mean age of patients who did not complete the telemedicine follow-up (58%) was 75.8 ± 9.7 years. Age was found to be a statistically significant difference between the group that completed the telemedicine follow-up and the one that did not (p < 0.004). KOOS scores improved from 56.1 ± 11.3 to 77.4 ± 16.2, VAS scores decreased from 7.2 ± 2.1 to 2.8 ± 1.6, KSSf scores increased from 47.2 ± 13.3 to 77.1 ± 21.1, FJS scores improved from 43.4 ± 12.3 to 76.9 ± 22.9, and OKS scores increased from 31.9 ± 8.8 to 40.4 ± 9.9. All the differences were statistically significant (p < 0.05). The mean flexion improved from 88° ± 8° to 120° ± 12°. A radiographic evaluation showed a mean pre-operative mechanical axis deviation of 5.3 ± 8.0 degrees in varus, which improved to 0.4 ± 3.4 degrees of valgus post-operation. The survivorship at 5 years was 99%. Conclusions: Subject to small numbers, telemedicine presented as a useful instrument for performing remote monitoring after TKA. The most important factor in telemedicine success remains the patient’s skill, which is usually age-related, as older patients have much more difficulty in approaching a technological tool.
Our Experience in Diagnosing and Treating Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)
Authors: Shoham Gon , Haran Oriana , Singolda Roei , Madah Ehab , Magen Ada , Golan Orit , Menes Tehillah , Arad Ehud , Barnea Yoav
Published: January 2024

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T-cell lymphoma detected in association with textured implants. It presents as a fluid accumulation around the implant, usually years after the implantation. We present our experience in diagnosing and treating four patients with BIA-ALCL, each widely differing from the other. Data on patients’ surgical history, relevant medical information, and findings on pathological slides were retrieved from their medical charts and retrospectively reviewed. Each of the four patients was diagnosed with BIA-ALCL, one after breast augmentation, one after breast reconstruction with an implant, one after breast reconstruction with a latissimus dorsi flap and implant, and the fourth after the removal of breast implants. The cases were presented to a multidisciplinary team and subsequently underwent surgery. All four are currently free of tumors, as established by a negative follow-up via positron emission tomography-computed tomography. Although the incidence of BIA-ALCL is rare, these cases emphasize the need to rule out the diagnosis of BIA-ALCL in patients with textured implants or a history of implanted textured devices who present with symptoms such as late seroma or peri-implant mass. This pathology is typically indolent and slow-growing and heightened awareness for an early diagnosis could lead to quicker intervention and enhanced patient management.
Thinking Style Moderates the Impact of the Classroom Environment on Language Creativity
Authors: Lin Suqin , Duan Wenjin , Wang Yifan , Duan Haijun
Published: January 2024

The classroom environment significantly affects the development of creativity. This study examined the impact of the classroom environment on students’ creativity and the moderating role of thinking styles in this relationship. For this study, we recruited 451 students from six secondary schools. Data were collected using the Chinese Language Creativity Test, Classroom Environment Inventory, and Thinking Styles Inventory. Hierarchical regression analysis examined the moderating effect of thinking styles on the relationship between the classroom environment and creativity. The results showed that peer relationships in the classroom environment negatively influence students’ fluency and originality in creativity. At the same time, teachers’ evaluation and teaching methods positively affect the fluency of creativity. Thinking styles moderated the impact of the classroom environment on language creativity. This study identified four different moderating effects: the thinking styles matching the classroom environment can enhance language creativity, whereas the mismatched ones hinder it. However, matching would limit language creativity for individuals with creative thinking styles (e.g., legislative and anarchic thinking styles), while a mismatch can boost creative performance. The findings help educators understand students’ creativity with different thinking styles in various classroom environments and provide individualized and effective strategies for optimizing educational environments and enhancing language creativity.
Understanding Timing Error Characteristics from Overclocked Systolic Multiply–Accumulate Arrays in FPGAs
Authors: Chamberlin Andrew , Gerber Andrew , Palmer Mason , Goodale Tim , Gundi Noel Daniel , Chakraborty Koushik , Roy Sanghamitra
Published: January 2024

Artificial Intelligence (AI) hardware accelerators have seen tremendous developments in recent years due to the rapid growth of AI in multiple fields. Many such accelerators comprise a Systolic Multiply–Accumulate Array (SMA) as its computational brain. In this paper, we investigate the faulty output characterization of an SMA in a real silicon FPGA board. Experiments were run on a single Zybo Z7-20 board to control for process variation at nominal voltage and in small batches to control for temperature. The FPGA is rated up to 800 MHz in the data sheet due to the max frequency of the PLL, but the design is written using Verilog for the FPGA and C++ for the processor and synthesized with a chosen constraint of a 125 MHz clock. We then operate the system at a frequency range of 125 MHz to 450 MHz for the FPGA and the nominal 667 MHz for the processor core to produce timing errors in the FPGA without affecting the processor. Our extensive experimental platform with a hardware–software ecosystem provides a methodological pathway that reveals fascinating characteristics of SMA behavior under an overclocked environment. While one may intuitively expect that timing errors resulting from overclocked hardware may produce a wide variation in output values, our post-silicon evaluation reveals a lack of variation in erroneous output values. We found an intriguing pattern where error output values are stable for a given input across a range of operating frequencies far exceeding the rated frequency of the FPGA.
Unlocking the Ocean 6G: A Review of Path-Planning Techniques for Maritime Data Harvesting Assisted by Autonomous Marine Vehicles
Authors: Zhao Liang , Bai Yong
Published: January 2024

Seamless integration of both terrestrial and non-terrestrial networks is crucial to providing full-dimensional wireless and ubiquitous coverage, particularly catering to those engaged in marine activities. Compared to terrestrial networks, wireless communications in the marine domain are still not satisfactory for ubiquitous connectivity. Featuring agile maneuverability and strong adaptive capability, autonomous marine vehicles (AMVs) play a pivotal role in enhancing communication coverage by relaying or collecting data. However, path planning for maritime data harvesting is one of the most critical issues to enhance transmission efficiency while ensuring safe sailing for AMVs; yet it has rarely been discussed under this context. This paper provides a comprehensive and holistic overview of path-planning techniques custom-tailored for the purpose of maritime data collection. Specifically, we commence with a general portrayal of fundamental models, including system architectures, problem formulations, objective functions, and associated constraints. Subsequently, we summarize the various algorithms, methodologies, platforms, tools, coding environments, and their practical implementations for addressing these models. Furthermore, we delve into the burgeoning applications of path planning in the realm of maritime data harvesting and illuminate potential avenues for upcoming research endeavors. We believe that future research may focus on developing techniques to adapt more intricate and uncertain scenarios, such as sensor failures, inaccurate state estimations, complete modeling of communication channels, ocean dynamics, and application of heterogeneous systems.
Distribution Characteristics and Factors Controlling Different Phosphorus Fractions in the Soils and Sediments of an Inland Lagoon
Authors: Yuan Kun , Wang Rui , He Bo , Fu Guowei , Song Yanwei , Pei Lixin , Fan Shichao , Gao Fangyi
Published: January 2024

Lagoons, significant coastal wetlands, stand out for their vital role in the cycles and transformations of phosphorus. However, the relationship between the spatial distributions of various phosphorus forms in the soil and sediments of lagoon areas remains unclear. This study investigated the phosphorus fractions and distribution patterns in the soil and sediments from Shimei Inland Sea, Hainan Province, China, and identified the factors controlling phosphorus distribution and its relationship with lagoon eutrophication. The results revealed significant enrichment of inorganic phosphorus (IP) in the Shimei Inland Sea (64.1–679.0 mg/kg) and offshore areas (56–627.2 mg/kg), while organic phosphorus (OP) was relatively concentrated in land (60–744.3 mg/kg), suggesting that the productivity of the terrestrial ecosystem controlled the OP content and IP formed from the mineralization of OP was more likely to leach into the water and combine with minerals. Total phosphorus (TP) content was negatively affected by pH, and organic matter, cation exchange capacity and iron/aluminum oxides showed significant positive correlations with TP content. These findings highlighted the coupled impact of soil and sediment physicochemical properties on phosphorus enrichment and transformation, providing theoretical support for the ecological restoration of ecosystems in tropical coastal wetlands.
Pile Driving and the Setup Effect and Underlying Mechanism for Different Pile Types in Calcareous Sand Foundations
Authors: Gao Yan , Guo Zixin , Yuan Quan
Published: January 2024

The mechanical response and deformation characteristics in calcareous sand foundations during pile driving and setup were studied using model tests combined with the technical methods of tactile pressure sensors and close-range photogrammetry. Different types of piles were considered, including a pipe pile, square pile and semi-closed steel pipe pile. The test results show that during pile driving, the pile tip resistance of different piles increases with an increase in the pile insertion depth, and an obvious fluctuation is also obtained due to the particle breakage of the calcareous sand and energy dissipation. Different degrees of particle breakage generated by different type piles make the internal stress variations different, as with the pile tip resistance. The pile tip resistance of model pile A, which simulates a pipe pile, is the highest, followed by model pile B, the simulated square pile. Model pile C, which simulates a semi-closed steel pipe pile, has the smallest pile tip resistance because its particle breakage is the most obvious and the pile tip energy cannot be continuously accumulated. The induced deformation such as sag or uplift on the surface and the associated influence range for the calcareous sand foundation are the smallest for model pile C, followed by model pile B and then model pile A. Model pile A has the most obvious pile driving effect. During the pile setup process after piling, the increase in the total internal stress of model pile B is the largest, and the improvement of the potential bearing capacity is the most obvious, followed by model pile A and model pile C. During the pile setup, the induced uplift deformation in pile driving is recovered and the potential bearing capacity increases due the redistribution and uniformity of the vertical and radial stress distributions in the calcareous sand foundation. Considering the potential bearing capacity of different model piles, the influence range of pile driving, foundation deformation and the pile setup effect, it is suggested to use a pointed square pile corresponding to model pile B in pile engineering in calcareous sand foundations.
An Ensemble CNOP Method Based on a Pre-Screening Mechanism for Targeted Observations in the South China Sea
Authors: Wang Ru , Zheng Qingyu , Li Wei , Han Guijun , Wang Xuan , Hu Song
Published: January 2024

The uncertainty in the initial condition seriously affects the forecasting skill of numerical models. Targeted observations play an important role in reducing uncertainty in numerical prediction. The conditional nonlinear optimal perturbation (CNOP) method is a useful tool for studying adaptive observation. However, the traditional CNOP method highly relies on the adjoint model, and it is difficult to find the global optimal solution. In this paper, a pre-screening and ensemble CNOP hybrid method called PECNOP is proposed to identify optimal sensitive areas in targeted observations. PECNOP is an adjoint-free method that captures global CNOP with high probability, which can effectively solve the two major problems faced by traditional CNOP methods. We evaluated the performance of PECNOP by building an observation simulation system consisting of an ocean model and data assimilation. One of the assimilation experiments was dedicated to evaluating the stability and effectiveness of PECNOP in extreme events. The results show that, compared with traditional methods, PECNOP can stably capture the global CNOP. Extra observations and assimilation in the optimal sensitive areas identified by PECNOP can effectively improve forecasting by about 20% within 30 days. Therefore, PECNOP has potential to reduce the initial error of numerical models, which is important for improving forecasting.
Specific Phylotypes of Saprolegnia parasitica Associated with Atlantic Salmon Freshwater Aquaculture
Authors: Shreves Kypher Varin , Saraiva Marcia , Ruba Tahmina , Miller Claire , Scott E. Marian , McLaggan Debbie , van West Pieter
Published: January 2024

Saprolegniosis is a major destructive disease in freshwater aquaculture. The destructive economic impact of saprolegniosis on freshwater aquaculture necessitates further study on the range of Saprolegnia species within Atlantic salmon fish farms. This study undertook a thorough analysis of a total of 412 oomycete and fungal isolates that were successfully cultured and sequenced from 14 aquaculture sites in Scotland across a two-year sampling period. An ITS phylogenetic analysis of all isolates was performed according to whether they were isolated from fish or water samples and during enzootic or epizootic periods. Several genera of oomycetes were isolated from sampling sites, including Achlya, Leptolegnia, Phytophthora, and Pythium, but by far the most prevalent was Saprolegnia, accounting for 66% of all oomycetes isolated. An analysis of the ITS region of Saprolegnia parasitica showed five distinct phylotypes (S2–S6); S1 was not isolated from any site. Phylotype S2 was the most common and most widely distributed phylotype, being found at 12 of the 14 sampling sites. S2 was overwhelmingly sampled from fish (93.5%) and made up 91.1% of all S. parasitica phylotypes sampled during epizootics, as well as 67.2% of all Saprolegnia. This study indicates that a single phylotype may be responsible for Saprolegnia outbreaks in Atlantic salmon fish farms, and that water sampling and spore counts alone may be insufficient to predict Saprolegnia outbreaks in freshwater aquaculture.
Vulvar Lichen Sclerosus: Navigating Sex Hormone Dynamics and Pioneering Personalized Treatment Paradigm
Authors: Popa Adelina , Dumitrascu Mihai , Petca Aida , Petca Razvan-Cosmin , Sandru Florica
Published: January 2024

Vulvar lichen sclerosus (VLS) is a frequently overlooked inflammatory disorder affecting the skin and mucous membranes of the vulva. With a propensity for atrophy, severe scarring, functional impairment, and malignant evolution, VLS is a disease that recurs frequently; early diagnosis, rapid treatment, and ongoing patient follow-up are essential. Potent topical corticosteroids (TCSs) are now widely recognized as the most effective treatment for achieving remission in VLS, but considering the potential complications of long-term treatment with potent TCSs, understanding the evolution of VLS during puberty becomes particularly crucial in determining the necessity for aggressive or more conservative therapeutic interventions. Emerging treatments, including PRP (platelet-rich plasma), stem cell therapy, and energy-based lasers like fractional CO2 and Nd-YAG, are being investigated to identify more effective VLS treatments than ultrapotent topical corticosteroids. However, more research is needed to assess the efficacy and safety of these new medicines. Topical clobetasol 0.05% ointment daily for 4–12 weeks is the gold standard for treating VLS. This article is a narrative review of the English-language medical literature from 2017 to November 2023, following three main sections concerning VLS: studies of the evolution amid pubertal hormonal changes; studies of the outcomes of personalized conventional therapies; and studies addressing the spectrum of innovative modalities for VLS.
Paediatric Neurology: Current Trends, Rehabilitation, and Future Challenges
Authors: Romeo Domenico M. , Brogna Claudia
Published: January 2024

Over the past 20 years, the introduction of new neurodevelopmental assessments and neurophysiological techniques has improved the knowledge of the complexity of the central nervous system in the first period of development [...]
High Resolution 3D Model of Heritage Landscapes Using UAS LiDAR: The Tajos de Alhama de Granada, Spain
Authors: Vílchez-Lara María del Carmen , Molinero-Sánchez Jorge Gabriel , Rodríguez-Moreno Concepción , Gómez-Blanco Antonio Jesús , Reinoso-Gordo Juan Francisco
Published: January 2024

The Tajos de Alhama de Granada, which since ancient times have inspired and surprised locals and strangers, especially foreign travelers, constituted a unique landscape, cultural and ethnological heritage of Spain, linked to water and its old flour mills. And, they are currently at serious risk of degradation. The aim of this research is to obtain a high-resolution 3D model capable of documenting this historical heritage environment with a high level of detail, using a methodology that includes small light weight LiDAR (Light Detection and Ranging) system for UAS (Unmanned Aircraft System). The model obtained should serve, on the one hand, as a valuable tool for knowledge and analysis of all the elements (river, lake, ditches, dams, mills, aqueducts, and paths) that made up this place, registered as a picturesque landscape for its extraordinary beauty and uniqueness, and on the other hand, as a basis for the development of rehabilitation and architectural restoration projects that would have to be undertaken to preserve this cultural and landscape legacy.
Lexical–Syntactic Classes of Adjectives in Copular Sentences across Spanish Varieties: The Innovative Use of Estar
Authors: Gumiel-Molina Silvia , Moreno-Quibén Norberto , Pérez-Jiménez Isabel
Published: January 2024

This paper aims to provide a clearer understanding of the structure known in the literature as the innovative use of estar, illustrated in sentences like Luego salgo/voy a visitar usuarios que están muy morosos [Medellín, Colombia; Preseea] (“Today I am going to visit users that are.ESTAR defaulting debtors”). In such sentences, no comparison is established between stages or counterparts of the subject of predication with regard to the property expressed by the adjective, as opposed to estar-sentences in standard/general Spanish. This innovative structure is a syntactic scheme employed throughout different Latin American Spanish varieties. The goal of this paper is twofold: it is both descriptive and theoretical. From a descriptive perspective, it offers an exhaustive and updated empirical characterization of the extent of this structure in Latin American Spanish based on an analysis of the Preseea corpus. This description takes into consideration both its geographical distribution in the different Latin American dialectal varieties and the lexical–syntactic classes of adjectives that appear as predicates in innovative estar-sentences. Building on this, from a theoretical point of view, a critical evaluation is made of the existing proposals in the literature that explain the properties—both syntactic and semantic—of the innovative construction.
Novel Therapeutic Agents for Management of Diabetes Mellitus: A Hope for Drug Designing against Diabetes Mellitus
Authors: Elkhalifa Ahmed M. E. , Nazar Mehak , Ali Sofi Imtiyaz , Khursheed Ibraq , Taifa Syed , Ahmad Mir Muzafar , Shah Iqra Hussain , Malik Masood , Ramzan Zahid , Ahad Shubeena , Bashir Nusrat , Elamin Elham , Bazie Elsharif A. , Ahmed Elsadig Mohamed , Alruwaili Majed Mowanes , Baltoyour Ammar W. , Alarfaj Abdullah Salah , Ali Al Bataj Ibrahim , Arabe Abdullah M. A. , Nabi Showkat Ul
Published: January 2024

Diabetes mellitus (DM) is characterized by an absolute decline in insulin secretion and peripheral resistance and is the most prevalent metabolic and endocrine disorder. However, the pathogenesis of DM also includes adipocyte insulin resistance, increased glucagon secretion, increased renal glomerular glucose absorption, and neurotransmitter dysfunction. Although there is a wide spectrum of therapeutics available for glycemic control, owing to the identification of various pathogenic determinants of DM, management of DM remains challenging and complex. Current therapeutic interventions against DM focus mostly on glycemic control without considering the other pathological determinants that eventually lead to treatment failure and the progression of DM. Furthermore, long-term use of these conventionally available anti-diabetic drugs leads to various side effects, henceforth development of novel drugs against DM remains an unending search strategy for researchers. Various studies conducted in various parts of the world have proposed that these novel therapeutic interventions target multiple and alternate pathogenic hotspots involved in DM. The current review article discusses novel therapeutic options that hold particular promise to support their safety and discuss the side effects resulting from their use so that these novel candidate drugs can be effectively fabricated into potential drugs for the treatment of DM.