bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of bone metastasis of castration-resistant prostate cancer after enzalutamide and abiraterone using Bone Scan Index on bone scintigraphy.
Authors: Kadomoto Suguru , Izumi Kouji , Nohara Takahiro , Hiroyuki Konaka , Kadono Yoshifumi , Kitagawa Yasuhide , Nakajima Kenichi , Mizokami Atsushi
Published: March 2017

e596

Background: It was ambiguous till now to evaluate the change of bone metastasis by various treatments. To quantify the change of bone metastases by enzalutamide, abiraterone, and docetaxel for the castration-resistant prostate cancer (CRPC) with bone metastases (bmCRPC), we employed Bone Scan Index (BSI) on bone scintigraphy. Methods: We retrospectively evaluated the change of PSA and bone metastases of CRPC patients who were treated with enzalutamide (Enz), abiraterone (Abi) and/or docetaxel (DOC) in our hospital. All patients underwent Tc-99m MDP bone scintigraphy. The degree of bone metastases was analyzed using BSI, which was calculated by BONENAVI (FUJIFILM RI Pharma, Japan; EXINIbone, EXINI Diagnostics, Sweden). 19 patients were treated with enzalutamide (8 cases: pre-docetaxel, 11 cases: post-docetaxel). The median PSA of patients treated with Enz was 12.64 ng/ml (1.63-199 ng/ml). And 11 patients were treated with abiraterone (5 cases: pre-docetaxel, 6 cases: post-docetaxel). The median PSA of patients treated with Abi was 26.37 ng/ml (2.29-199 ng/ml). Results: We observed decline of PSA in 18/30 cases (9 cases: pre-DOC, 9 cases: post-DOC). Decline of PSA to 50% or more was observed in 14 cases. In contrast, decline of BSI was observed in 53.3% (16/30) cases and decline of PSA to 25% or more was observed in only 6 cases. BSI decreased in 84.6% (11/13) of pre-DOC setting and in 29.4% (5/17) of post-DOC setting indicating that change of BSI was poor in post-DOC setting. However, DOC had already decreased BSI in 91.7% (11/12) before Abi or Enz treatment. Moreover, the average rate of BSI decline in the patients that BSI decreased by DOC was better than the patients that BSI decreased by Abi/Enz (-48.46% vs -28.56%). Finally, although the rate of BSI change by Enz was weakly correlated with the rate of PSA decline (y = 0.3906x + 25.35, R2 = 0.3423), BSI continued to increase in four cases in spite of PSA decline. Conclusions: BSI using BONENAVI on bone scintigraphy was helpful for evaluating the effectiveness of treatment and following-up of bmCRPC.
Does Gleason pattern 5 influence the efficacy of enzalutamide against castration-resistant prostate cancer?
Authors: Shimomura Tatsuya , Yamada Hiroki , Naruoka Takehito , Mori Keiichiro , Hata Kenichi , Igarashi Taro , Kimura Takahiro , Egawa Shin
Published: March 2017

e598

Background: In this study, we evaluated our cohort treated with enzalutamide retrospectively. We focused on Gleason pattern 5 prostate cancer which was very aggressive cancer and we investigated the difference in efficacy of enzalutamide between the groups including Gleason pattern 5 or not, to understand if initial aggressiveness of prostate cancer influence the enzalutamide responses. Methods: A total of 190 CRPC cases treated with enzalutamide between June 2014 and July 2016 at our university and affiliated institutions were included in this study. We evaluated clinical and pathological factors, Prostate specific antigen(PSA) responses, and overall survival, retrospectively. Results: Of these, 80 cases did not have Gleason pattern 5 and 110 cases had Gleason pattern 5 (Gleason Score 4+5, 5+4 or 5+5). Initial PSA level was higher and metastasis was more frequent in Gleason pattern 5 group (p = 0.0328, and 0.0171, respectively). Docetaxel pretreatment, abiraterone pretreatment, PSA and other serological data at starting enzalutamide were not different between the groups other than steroidal use (p = 0.0441). Overall survival rate at 1 year and 2 years were 84.3% and 77.2% in Gleason pattern 5 negative cohort, and 81.2% and 63.5% in Gleason pattern 5 cohort (p = 0.2459). There were no differences in terms of PSA responses between these groups. Mean PSA decline rate (pattern 5 negative vs. positive) were 57.1% vs. 54.6% (p = 0.6555). ≥ 50% PSA decline rate were 62.5% vs. 60.9% (p = 0.8329), ≥ 90% decline rate were 28.75% vs. 28.2% (p = 0.9317). Conclusions: In this study, we concluded that aggressiveness of initial status did not influence the efficacy of enzalutamide treatment. And disease status might be almost same when introducing enzalutamide. Of course, we need to recognize that initial androgen deprivation therapy (ADT) could be more efficient for lower Gleeson pattern than higher Gleeson pattern. However there is possibility that aggressiveness of prostate cancer cell would change through ADT and/or chemotherapy. We should investigate how prostate cancer is changing and should evaluate the prostate cancer cell status before starting treatment to predict the efficacy and to decide the treatment agents.
Absorption of a novel formulation of abiraterone acetate (AA) fine particle (AAFP) under fed and fasted conditions.
Authors: Papangelou Alexander , Olszanski Anthony J. , Stein Cy Aaron , Zhang Yuxin , Bosch Bill , Nemeth Paul
Published: March 2017

e606

Background: AA is approved for treatment of metastatic castration-resistant prostate cancer (mCRPC). In healthy subjects administered the originator AA (OAA) formulation, AUC and Cmaxincreased by 10- and 17-fold, respectively, when administered after a high-fat meal relative to the fasted state.1 AAFP is a proprietary formulation (utilizing SoluMatrix Fine-Particle Technology) of AA designed to improve the oral bioavailability (BA) of AA, and to potentially reduce food effects compared with the OAA formulation. In healthy subjects, AAFP 500 mg was established as bioequivalent to OAA 1000 mg in a prior study when taken in fasted conditions. Methods: Healthy male subjects (N = 25) fasted 10-h overnight before randomization in a crossover design to a single 500 mg dose of AAFP under fasted or fed (high-fat FDA breakfast 30 min before AAFP administration) conditions. There was a 7-day washout period prior to crossover; 22 subjects completed the study. Results: Drug exposure of AAFP 500 mg was significantly ( P< 0.0001) greater under fed vs fasted conditions (Table). Following a single dose of AAFP 500 mg, relative BA measured by the ratio of test-to-reference geometric means of AUC and Cmax of abiraterone indicated that drug exposure increased under fed conditions by approximately 4.5- and 6.5-fold, respectively, vs under fasted conditions. AAFP 500 mg was safe and well-tolerated under fed or fasted conditions. Conclusions: AAFP 500 mg under fed conditions has higher BA than under fasted conditions. A direct comparative study between AAFP 500 mg and OAA 1000 mg under restricted food conditions is underway in patients with mCRPC. 1US FDA. CDER. Abiraterone Acetate NDA 202379 Review, 2010. Clinical trial information: NCT02737332. [Table: see text]
Zebra finches have a light-dependent magnetic compass similar to migratory birds
Authors: Pinzon-Rodriguez Atticus , Muheim Rachel
Published: March 2017

Birds have a light-dependent magnetic compass that provides information about the spatial alignment of the geomagnetic field. It is proposed to be located in the avian retina and mediated by a light-induced, radical-pair mechanism involving cryptochromes as sensory receptor molecules. To investigate how the behavioural responses of birds under different light spectra match with cryptochromes as the primary magnetoreceptor, we examined the spectral properties of the magnetic compass in zebra finches. We trained birds to relocate a food reward in a spatial orientation task using magnetic compass cues. The birds were well oriented along the trained magnetic compass axis when trained and tested under low-irradiance 521 nm green light. In the presence of a 1.4 MHz radio-frequency electromagnetic (RF)-field, the birds were disoriented, which supports the involvement of radical-pair reactions in the primary magnetoreception process. Birds trained and tested under 638 nm red light showed a weak tendency to orient ∼45 deg clockwise of the trained magnetic direction. Under low-irradiance 460 nm blue light, they tended to orient along the trained magnetic compass axis, but were disoriented under higher irradiance light. Zebra finches trained and tested under high-irradiance 430 nm indigo light were well oriented along the trained magnetic compass axis, but disoriented in the presence of a RF-field. We conclude that magnetic compass responses of zebra finches are similar to those observed in nocturnally migrating birds and agree with cryptochromes as the primary magnetoreceptor, suggesting that light-dependent, radical-pair-mediated magnetoreception is a common property for all birds, including non-migratory species.
Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review
Authors: Alvarez María Fernanda , Bolívar-Mejía Adrián , Rodriguez-Morales Alfonso J. , Ramirez-Vallejo Eduardo
Published: March 2017

Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations.

Methods: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease. Cardiac compromise is not so common in isolated episodes; but countries where chikungunya virus is an epidemic should be well informed about this condition. We used 6 bibliographical databases as resources: Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue reports on cardiovascular affectation were included as well, to compare both arbovirus’ organic affectations. Articles that delved mainly into the rheumatic articular and cutaneous complications were not considered, as they were not in line with the purpose of this study. The type of articles included were reviews, meta-analyses, case-controls, cohort studies, case reports and case series.

Results: Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at least mentioning CHIKV cardiovascular compromise within the systemic affectation. Cardiovascular manifestations can be considered common and have been reported in France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive insufficiency, heart failure and altered function profile (Troponins, CPK).

Conclusions: Physicians should be encouraged to keep divulgating reports on the cardiovascular involvement of chikungunya virus disease, to raise awareness and ultimately encourage suitable diagnosis and intervention worldwide.
TO THE QUESTION OF THE KINETICS OF HEAT RELEASE DURING HYDRATION GYPSUM BINDER (Part I)
Authors: Дребезгова Мария , Drebezgova Mariya
Published: March 2017

In this article, using isothermal differential microcalorimeter that includes a number of devices for the automatic construction of dependency of dQ/dτ=f(τ) and Q= f(τ) was studied by thermo-kinetic regularities of the intensity and completeness of the early stages of hydration of gypsum binders G-5, G-16 and their combinations (G-5-70 % + G-16-30 %), since their mixing with water.
MODELING CONSTRUCTION OF MONOLITHIS CONCRETE FLOORS TAKING INTO ACCOUNT ORGANIZATIONAL - TECHNOLOGICAL RELIABILITY
Authors: Лебедев Владимир , Lebedev Vladimir , Беликова Галина , Belikova Galina
Published: March 2017

Work out the organizational and technological models and carried out in-line construction complex engineering preparation of construction production construction of monolithic concrete floors, taking into account the organizational and technological reliability
THE INFLUENCE ON NIOBIUM AND TITANIUM ON ELECTRICAL RESISTIVITY IN LIQUID STATE AND SOLYDIFICATION OF IN718 ALLOY
Authors: Tyagunov Andrey , Baryshev Evgeny , Tyagunov Gennady , Shmakova Kseniya , Tsepelev Vladimir
Published: March 2017

The electrical resistivity of IN 718 alloy was studied in a liquid state with contactless induction method of rotating magnetic field. Solidification process was studied by differential thermal analysis. It was founded that electrical resistivity varies in a complicated way with increasing temperature. It is shown that heating of the liquid metal above certain temperatures causes of hysteresis, i.e. discrepancy between the temperature dependences of heating and cooling. It was revealed, that the changes of niobium contents within alloy composition do not lead to a qualitative change of temperature dependence type, but accompanied by some peculiarities. Effect of titanium content on electrical resistivity changes within the alloy composition does not clearly detect. The temperature of maximal melt heating determines the degree of supercooling of liquid alloy.
NEW TECHNOLOGY FOR HARDENING READY-MADE TOOLS IN AQUAEOUS DISPERSED MEDIA
Authors: Shmatov Alexander A. , Soos Lubomir , Krajny Zdenko
Published: March 2017

The new method for hardening ready-made steels, hard alloys and diamond tools is developed: low-temperature process for producing thin-film solid lubricant coatings by hydro chemical treatment in specially prepared aqueous media of nanosized hard refractory compounds and subsequent tempering. The main advantages of the method over known processes are presented. The principles for dispersion of refractory materials are formulated. The structure and properties of the obtained coatings are examined. The fields of high compression strains (180-470 МPа) are created in tool materials subjected to hydro chemical treatment. The new process permits decreasing the friction coefficient of tools surface in 3.8-12.1 and increasing the service life of steel, carbide and diamond tools by the factor of 1.5-8 as compared with untreated materials.
A Methodological Framework of Travel Time Distribution Estimation for Urban Signalized Arterial Roads
Authors: Zheng Fangfang , van Zuylen Henk , Liu Xiaobo
Published: March 2017

Urban travel times are rather variable as a result of a lot of stochastic factors both in traffic flows, signals, and other conditions on the infrastructure. However, the most common way both in literature and practice is to estimate or predict only expected travel times, not travel time distributions. By doing so, it fails to provide full insight into the travel time dynamics and variability on urban roads. Another limitation of this common approach is that the effect of traffic measures on travel time reliability cannot be evaluated. In this paper, an analytical travel time distribution model is presented especially for urban roads with fixed-time controlled intersections by investigating the underlying mechanisms of urban travel times. Different from mean travel time models or deterministic travel time models, the proposed model takes stochastic properties of traffic flow, stochastic arrivals and departures at intersections, and traffic signal coordination between adjacent intersections into account, and therefore, is able to capture the delay dynamics and uncertainty at intersections. The queue spillback phenomenon is explicitly taken into account by applying shockwave theory in a probabilistic way. The proposed model was further validated with both VISSIM simulation data and field GPS data collected in a Chinese city. The results demonstrate that the travel time distributions derived from the analytical model can well represent those from VISSIM simulation. The comparison with field GPS data shows that the model estimated link and trip travel time distributions can also represent the field travel time distributions, though a small discrepancy can be observed in both middle range travel times and higher travel times.
Optimal allocation of stratified sampling design using Gradient Projection method
Authors: Lone M. A , Mir S. A , Khan Imran , Wani M. S
Published: March 2017

This article deals with the problem of finding an optimal allocation of sample sizes in stratified sampling design to minimize the cost function. In this paper the iterative procedure of Rosen’s Gradient projection method is used to solve the Non linear programming problem (NLPP), when a non integer solution is obtained after solving the NLPP then Branch and Bound method provides an integer solution.
Packet Drop Attack Detection and Prevention Using Rank Base Data Routing in MANET
Authors: Patel Rajan , Vhora Sumaiya , Patel Nimisha
Published: March 2017

Packet drop (grayhole/blackhole) attack is occurs at a network layer to discard the packets in MANET. It is essential to detent and prevent this attack for improving performance of network. This article provides the packet drop attack detection and prevention using RBDR (Rank Based Data Routing) for AOMDV routing protocol. The fields of RBDR are generated with routing information and analysis behavior of network for detecting the malicious paths. The scheme is to identify the malicious paths for preventing the packet drop attack and also able to find the trusted multiple disjoint loop free routes for data delivery in MANET. The simulation is conducted in NS2 using AOMDV reactive routing protocol and analyze with packet loss delivery, average end-to-end delay and packet delivery ratio. The proposed technique can reduce the effect of packet drop attack.
Security with respect to MANET (Mobile Ad-hoc Network) and IoT (Internet of Things)
Authors: Agrawal Vikram
Published: March 2017

MANET is self organizing, decentralized and dynamic network. In which participating nodes can move anywhere. The nodes can be host or router anytime [1]. Mobile ad hoc network is decentralized network so if one node is participating as router for particular time but if that node leave network then it is very difficult to transfer data packets. The main feature of MANET network of self organizing capability of node has advantage and disadvantage as well. By this it is easy to maintain network and convert topology but at same time we need to tolerate data transfer. The MANET is also used for big network and internet but there is no smart objects like IoT which can share information machine to machine. Now rapidly increase internet users worldwide to access global information and technology [2]. IoT is basically used to converge applications and services to open global business opportunities which can use I-GVC (Information-driven Global Value Chain) for efficient productivity.
A New 8T SRAM Circuit with Low Leakage and High Data Stability Idle Mode at 70nm Technology
Authors: Raikwal P , Neema V , Verma A
Published: March 2017

Memory has been facing several problems in which the leakage current is the most severe. Many techniques have been proposed to withstand leakage control such as power gating and ground gating. In this paper a new 8T SRAM cell, which adopts a single bit line scheme has been proposed to limit the leakage current as well as to gain high hold static noise margin. The proposed cell with low threshold voltage, high threshold voltage and dual threshold voltage are used to effectively reduce leakage current, and delay. Additionally, the comparison has been performed between conventional 6T SRAM cell and the new 8T SRAM cell. The proposed circuit consumes 671.22 pA leakage current during idle state of the circuit which is very less as compare to conventional 6T SRAM cell with sleep and hold transistors and with different β ratio. The proposed new 8T SRAM cell shows highest noise immunity 0.329mv during hold state. Furthermore, the proposed new 8T SRAM circuit represents minimum read and write access delays 114.13ps and 38.56ps respectively as compare to conventional 6T SRAM cell with different threshold voltages and β ratio.
Eighteenth Order Convergent Method for Solving Non-Linear Equations
Authors: Vatti V.B , Sri Ramadevi , Mylapalli M.S
Published: March 2017

In this paper, we suggest and discuss an iterative method for solving nonlinear equations of the type f(x)=0 having eighteenth order convergence. This new technique based on Newton’s method and extrapolated Newton’s method. This method is compared with the existing ones through some numerical examples to exhibit its superiority.

AMS Subject Classification: 41A25, 65K05, 65H05.
Surviving the Intercollegiate Specialty Examination in General Surgery (FRCS)
Authors: Appleton ND , Kalaiselvan R
Published: March 2017

Helpful and practical tips to get you through it, bit by bit.
Perbedaan Pengaruh antara Pengaturan Suhu Ruang Operasi 240-260C dan 200-220C Terhadap Suhu Bayi Lahir Kurang Bulan
Authors: Wibowo Sukma , Salimo Harsono , Hidayah Dwi
Published: March 2017

Latar belakang. Bayi kurang bulan rentan terhadap stres dingin sehingga berisiko terjadi hipotermi. Hal ini menjadikan faktor suhu ruangan sangat penting sebagai bagian dari manajemen suhu pada kelahiran bayi kurang bulan.Tujuan. Menganalisis perbedaan pengaruh antara pengaturan suhu ruang operasi 240-260C dan 200-220C terhadap suhu bayi kurang bulan berat lahir rendah.Metode. Uji klinis dengan randomisasi dilakukan pada bulan Oktober 2016–Januari 2017 di ruang operasi IGD RS Dr. Moewardi Surakarta. Enampuluh bayi diambil secara konsekutif dibagi dalam kelompok kontrol (suhu operasi 200-220C) dan kelompok perlakuan (suhu ruang operasi 240-260C). Distribusi data tidak normal sehingga dalam bentuk median dan dianalisis menggunakan chi square dan Mann-Whitney test dengan program SPSS 17.0.Hasil. Median suhu bayi baru lahir pada kelompok perlakuan (36,10C) berbeda signifikan (p<0,001) secara statistik dibandingkan pada kelompok kontrol (35,70C), tetapi tidak berbeda secara klinis. Hasil analisis regresi linear ganda menunjukkan bahwa suhu ruang operasi (B=0,111; IK95%: 0,072 – 0,150; p<0,001), berat lahir (B=0,001; IK95%: 0,000 – 0,001; p<0,001), dan skor APGAR 1 menit (B=0,111; IK95%: 0,026 – 0,196; p=0,012) memiliki korelasi positif yang secara statistik signifikan dengan suhu bayi baru lahir.Kesimpulan. Suhu ruang operasi 240-260C akan menaikan median suhu lahir bayi kurang bulan, walaupun kejadian hipotermia tidak berbeda. Sari Pediatri
SPATIAL VARIETY AND DISTRIBUTION OF TRADITIONAL MARKETS IN SURAKARTA AS POTENTIAL FACTORS IN IMPROVING SPATIAL-BASED MANAGEMENT
Authors: Aliyah Istijabatul , Setioko Bambang , Pradoto Wisnu
Published: March 2017

Traditional markets function as trading place, socio-culture interaction, and recreation facility either in regional or urban scope. Distribution and variety of spatial condition influence traditional markets’ planning both physically and non-physically. Therefore, this research aims to conduct a mapping of traditional markets’ spatial distribution and variety as potential factors to improve spatial-based management. The research location is Surakarta City by applying analysis method including : 1) Mapping by employing Geographic Information System, 2) Category Based Analysis (CBA), and 3) Interactive Analysis. The result of this research signifies that spatial variety and distribution of traditional markets in Surakarta have similar pattern between one market to other markets; overlapping service function; specific commodity types in accordance with the market’s characteristics; diverse operating hours. Spatial variety and distribution could be potential factors to improve traditional market management as shopping service. It contrasts with Central Place Theory by Christaller and NÆss & Jensen’s research finding on distance which becomes a key factor influencing accessibility to a number of activity facilities. Therefore, distance toward the service center is not the main factor in traditional market management. However, the main factor in managing and controlling traditional markets’ development includes service function, commodity specification, and operating hours flexibility.
Challenges of Climate Change: Resilience Efforts in Rural Communities of Kaliwlingi Village
Authors: Azahro Mustovia , Ardi Angga Dwisapta
Published: March 2017

Kaliwlingi Village located in the Brebes City, northern coast of Central Java had experience about climate change such tidal flood and abrasion. The climate change causes the dynamics of the coast and sea level dramatically and fosters the coastal communities to have adaptation strategies. This paper aims to identify how the community of Kaliwlingi Village adapts to the climate change that affects to a social economic condition of the inhabitants. The study used the qualitative method by interpreting data from Pengembangan Kawasan Pesisir Tangguh (PKPT) program, interviews, and observations. The study highlights that PKPT program has a significant impact, especially regarding disaster mitigation. PKPT program is successful collecting the common rules of the community become social capital and accommodated in the local institution. Furthermore, the PKPT Program is also fostering the local economic.
„Der Glaube ist ein schäftig, tätig Ding“
Authors: Herms Eilert
Published: March 2017

Gezeigt wird, dass Luthers Sicht des
Enhancement of glucose oxide electron-transfer mechanism in glucose biosensor via optimum physical chemistry of functionalized carbon nanotubes
Authors: TermehYousefi Amin , Tanaka Hirofumi , Bagheri Samira
Published: March 2017

Nanostructures are a viable candidate for the construction of simple blood sugar monitoring devices. Electrochemical oxidation based on the immobilization of glucose oxidase (GOx) on carbon nanostructures has paved the way for a modern approach to the determination of glucose levels in blood. Carbon nanotubes (CNTs) exhibit excellent electrical properties, resulting in increased interest in glucose biosensors based on CNTs. Its large surface area and optimum aspect ratio increase the total amount of immobilized biomaterials onto its surface. In this contribution, recent advances in the development of reliable methods to improve the electron-transfer mechanism of GOx in CNT-based glucose biosensors are highlighted. Moreover, mass production and growth mechanism of purified CNTs by chemical vapor deposition were discussed by emphasizing its growth-control aspects.
Multimodale Sehflächen lesen. Eine semiotische Analyse jugendlicher Bekleidung
Authors: Staubach Katharina
Published: March 2017

By the way that we dress, we communicate a certain style to our social environment. Because of a process of searching and expressing an own identity, fashion and self-stylization processes have a special significance to young people in adolescence. The following article investigates the ways in which a youthful style can be expressed by the clothing of young people. Subject of the analysis is the multimodal language-picture-text prints in a corpus of 70 T-shirt- and sweatshirt photographs of adolescents’ clothes. Special focus is placed on the characteristics of linguistic and visual elements as well as on their multimodal relations.
Johannes Brassart’s Summus secretarius
Authors: Saucier Catherine
Published: March 2017

The motet Summus secretarius remains an enigma in the polyphonic output of the south Netherlandish composer Johannes Brassart (ca. 1400/5–1455). While extant sources (I-Bc Q15 and GB-Ob 213) attest to Brassart’s authorship, the message and function of this motet have long perplexed musicologists seeking to identify the work’s elusive subject and understand its cryptic language. Who is the “highest secretary” hailed at the outset, and what is this figure’s relationship to the biblical and cosmological references in the ensuing lines?

Summus secretarius reveals its secrets when examined within the context of the medieval cult of St. John the Evangelist. Taking cues from Brassart’s careful musical treatment of words quoted from the Gospel of John (1:1), we can decipher the motet’s language and symbolism using a diverse array of exegetical writings, images, and liturgical music that illuminate the unique status of John as Christ’s most intimate confidant, the seer and evangelist privy to his secrets. Brassart would have experienced the evangelist’s cult most vividly through his service as singer, chaplain, priest, and canon at the collegiate church of Saint-Jean l’Evangéliste in Liège—the most likely place for the motet’s composition and performance. Summus secretarius demonstrates to an exceptional degree the hermeneutic richness of enigmatic language in the unique texts of freely composed fifteenth-century motets.
MANAGEMENT OF ENDOCRINE DISEASE: Quality of life tools for the management of pituitary disease
Authors: Webb Susan M , Crespo Iris , Santos Alicia , Resmini Eugenia , Aulinas Anna , Valassi Elena
Published: March 2017

Background

In the last few years, quality of life (QoL) has become an outcome measure in patients with pituitary diseases.

Objective

To describe the available data on QoL impairment evaluated with questionnaires in patients with pituitary diseases.

Design

Critical review of the pertinent literature and pragmatic discussion of available information.

Methods

Selection of relevant literature from PubMed and WOK, especially from the last 5 years and comprehensive analysis.

Results

QoL is impaired in all pituitary diseases, mostly in acromegaly and Cushing’s disease (similar to other causes of Cushing’s syndrome), but also in non-functioning pituitary adenomas and prolactinomas, especially in the active phase of the disease. Nevertheless, even after endocrine ‘cure’, scores tend to be below normative values, indicative of residual morbidity after hormonal control. The presence of hypopituitarism worsens subjective QoL perception, which can improve after optimal substitution therapy, including recombinant human growth hormone, when indicated.

Conclusions

To improve the long-term outcome of pituitary patients, helping them to attain the best possible health, it appears desirable to include subjective aspects captured when evaluating QoL, so that the affected dimensions are identified and if relevant treated. Additionally, being aware that treatment outcome may not always mean complete normalisation of physical and mental issues related to QoL can be a first step to adaptation and conforming to this new status.
TEISMŲ VAIDMUO ARBITRAŽO PROCESE PAGAL LIETUVOS TEISĘ
Authors: Audzevičius Ramūnas , Parchajev Denis
Published: March 2017

Straipsnyje pateikiama teismo įsikišimo kiekvienoje arbitražo proceso stadijoje niuansų apžvalga ir tiriamas priimtų ir siūlomų Lietuvos Respublikos komercinio arbitražo įstatymo pakeitimų bei formuojamos Lietuvos teismų praktikos indėlis į arbitražo, kaip ginčų sprendimo būdo, veiksmingumą ir visavertiškumą.
VIEŠOSIOS TVARKOS SĄVOKA „BRIUSELIS I“ REGLAMENTE
Authors: Kisieliauskaitė Agnė
Published: March 2017

Straipsnyje analizuojama viešosios tvarkos sąvoka „Briuselis I“ reglamente ir galimybė sėkmingai remtis viešosios tvarkos išlyga kaip laisvo sprendimų judėjimo Europos Sąjungoje išimtimi.
НЕКОТОРЫЕ ПРОБЛЕМНЫЕ ВОПРОСЫ СОБЛЮДЕНИЯ ПРИНЦИПА НЕЗАВИСИМОСТИ АДВОКАТСКОЙ ДЕЯТЕЛЬНОСТИ В АСПЕКТЕ ОБЯЗАТЕЛЬНОГО ЧЛЕНСТВА АДВОКАТА В НАЦИОНАЛЬНОЙ АССОЦИАЦИИ АДВОКАТОВ УКРАИНЫ
Authors: Заборовский Виктор Викторович
Published: March 2017

Закрепляя на конституционном уровне право каждого человека на профессиональную юриди­ческую помощь, государство возлагает такую обязанность на адвокатуру, а именно на адвоката, который на профессиональной основе должен обеспечивать надлежащую реализацию такого права. Актуальность данной темы заключается в том, что реализация такого права невозможна без обеспечения надлежащих условий осуществления адвокатской деятельности. Без сомнения, основополагающим условием осуществления такой деятельности является абсолютная незави­симость адвоката. Такая независимость адвоката включает в себя, в том числе и независимость от профессиональных ассоциаций адвокатов, которые в свою очередь должны играть важную роль в обеспечении независимости адвокатской деятельности. Поэтому актуальным остается вопрос: «Существование профессиональных ассоциаций адвокатов и в частности обязательное членство в них является нарушением принципа независимости адвокатской деятельности или нет?».[...]
PROCESO, KURIAME PAREIŠKIAMAS NETIESIOGINIS IEŠKINYS, ŠALYS
Authors: Vasileva Tatyana A.
Published: March 2017

Straipsnyje analizuojama šalies samprata Anglijos, JAV ir Rusijos teisėje. Autorius daro išvadą, kad byloje dalyvaujančio asmens – juridinio asmens ar jo organo – procesinė padėtis bylose, kuriose pareiškiamas netiesioginis ieškinys, priklauso nuo valstybėje galiojančios šalies sąvokos.В статье анализируется понятие «стороны» в английском, американском и российском праве. Автор приходит к выводу, что определение процессуального положения участника, юридического лица и органа в производстве по косвенному иску зависит от понятия “стороны”.
Agricultural support model: towards long-term viability
Authors: Jurkėnaitė Nelė , Volkov Artiom
Published: March 2017

Over the recent decades the EU CAP was criticized and the reform of direct payments was underlined as an important challenge empowering desired changes. The research challenges a problem of the national support model improvement in order to promote a welfare-orientated agriculture and ensure viability of family farms. The article aims to evaluate the relevance of the Lithuanian direct payments’ model for the period 2015–2020 and propose recommendations on the development of support model. The analysis of literature on viability and the CAP issues was conducted stressing the importance of the selected viability concept for agricultural policy development. The synthesis of previous research, calculus of variations and legislation analysis were employed to estimate the relevance of current direct payments’ model in Lithuania and identify the revision of redistributive payments as possible development directions aiming to ensure long-run viability of agriculture. The recommendations on the development of the current support model are based on the estimation of impact and the comparative analysis of the selected alternatives.
Gendering occupations
Authors: Ekberg Katie , Ekberg Stuart
Published: March 2017

In spite of increasing gender diversity in employment roles, presumptions persist about the gender of people employed in particular occupations. Focusing on healthcare data collected in Australia and the United Kingdom within the past decade, we use conversation analysis to identify how presumptions about gender are displayed within social interaction through the use of gender-specific pronouns. We show how gender-specific pronouns are asymmetrically selected on the basis of a referent’s occupations, with gender-unspecified members of traditionally male occupations (e.g. doctors) referred to with masculine pronouns and gender-unspecified members of traditionally female occupations (e.g. nurses) referred to with feminine pronouns. We also explore ways people avoid making such presumptions. Our analysis therefore reveals a state of flux in contemporary social life, with instances in which gender presumptions persist as well as attempts to employ person references that reflect contemporary social dynamics.
Negotiating the tall poppy syndrome in New Zealand workplaces
Authors: Holmes Janet , Marra Meredith , Lazzaro-Salazar Mariana
Published: March 2017

The ‘tall poppy syndrome’ (TPS) is one example of a societal constraint whose function in Australasia is to enforce society-wide ideologies such as egalitarianism and the gender order. The TPS acts as an enforcement mechanism which keeps self-promoting discourse in check. While carefully managed selfpromotion is permissible in some contexts, there are others where New Zealanders are expected to behave with modesty and humility. Using a social realist approach and drawing on data from four different professional contexts (a commercial company, a medical clinic, a government department and a nongovernmental organisation), this paper explores the discursive instantiation of the TPS in combination with potentially competing leader and gender identities as experienced by New Zealand women leaders. Finally, we ask if the pressure to conform to the egalitarian ethic, alongside other downplaying strategies, is gendered in New Zealand workplaces.
ATTACHMENT PLACE: STUDI FENOMENOLOGI SPECIAL PLACE ANAK USIA DINI DI PAUD ISLAM DAN TK ISLAM DI KABUPATEN MALANG
Authors: Mukhlis Akhmad
Published: March 2017

Bahasa Indonesia:

Penelitian ini bertujuan untuk mengetahui kelekatan tempat (attachment place) pada anak usia dini. Berbeda dengan penelitian-penelitian sebelumnya, penelitian ini memfokuskan kajiannya pada tempat-tempat yang dianggap spesial (special place) oleh anak di lingkungan rumah mereka. Metodologi fenomenologi dipilih untuk mengeksplorasi tujuan penelitian dalam dua tahap. Tahap pertama dilkaukan di sekolah dengan mendiskusikan buku dengan 13 peserta didik. Tiga anak yang paling aktif dan mampu berkomunikasi dengan baik diminta untuk menjadi partisipan pada tahap kedua yaitu kunjungan rumah. Dua tahapan penggalian data menemukan bahwa anak-anak memiliki banyak tempat yang dianggap spesial. Keberadaan tempat-tempat tersebut biasa digunakan untuk bersembunyi, meredakan emosi, bermain dan mengembangkan rasa otonomi diri.

 

English:

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PENGEMBANGAN KAPASITAS INSTITUSI DAN SUMBER DAYA MANUSIA DI MADRASAH: PENDEKATAN TOTAL QUALITY MANAGEMENT
Authors: Mo'tasim Mo'tasim
Published: March 2017

Bahasa Indonesia:

Pengembangan kapasitas institusi dan sumber daya manusia di madrasah merupakan misi penting dalam meningkatkan kualitas pendidikan Islam dewasa ini. Namun, manajerial kelembagaan madrasah masih belum memenuhi ekspektasi yang diharapkan jika dilihat dari kreativitas dan inovasinya. Melihat fenomena tersebut, kiranya upaya untuk menciptakan kondisi yang kondusif dalam mencapai tujuan pendidikan adalah mutlak membutuhkan budaya manajemen yang kualitas melalui Total Quality Management (TQM) adalah salah satu alternatif. Dengan manajemen tersebut, diharapkan efektifitas pola kerja di madrasah akan dapat terwujud secara menyeluruh. Artikel ini mengkaji tentang peran kepala madrasah dalam mengembangkan kapasitas institusi dan sumberdaya manusia melalui pendekatan TQM. Artikel ini mendeskripsikan penerapan TQM  dengan library research melalui analisis deskriptif non-statistik sebagai penyajian datanya.  Sebagai kesimpulan, kepemimpinan dan manajerial kepala madrasah berperan penting dalam menentukan  kebutuhan lembaga dan menyusun visi, misi dan tujuan lembaga. Di sisi lain, efektifitas TQM ditentukan oleh kemampuan kepala madrasah dalam hal manajerial, gagasan pembaharuan, efektifitas proses pembelajaran, pengelolaan tenaga kependidikan yang baik, partisipasi warga madrasah dan masyarakat, akuntabilitas dan motivasi untuk mewujudkan tim kerja yang solid.

English:

Institutional and human capacity development in madrasah is central in developing islamic education quality nowadays. However, the institutional management in madrasah has not yet meet the expectation from its creativity and innovation. Based upon the phenomenon, this paper offers   Total Quality Management (TQM) as an alternative to create conducive atmosphere in madrasah for achieving educational purposes. The management expects holistic-effective workflow in madrasah. This article focuses on the role of madrasah principal in developing institutional and human capacity through the TQM. With library research, this article describes the TQM implementation and provides descriptive non-statistical analysis in providing the data. As a conclusion, the madrasah principal’s leadership and managerial role are the very important factors to decide intitutional needs and constructing institutional visions-missions-aims. In addition, the TQM effectiveness depends on the principal’s ability in managing, offering innovation, creating effective learning activities, managing staffs, involving stakeholders, promoting accountability, and motivating people for a solid teamwork.
Electromagnetic fields at the sea bottom induced by a line of immersed electric dipoles
Authors: Sampaio Edson E.S.
Published: March 2017

The analysis of electromagnetic fields caused by alternate or transient electric currents flowing along a cable in sea water has several applications. It supports the interpretation of electromagnetic geophysical data and safety procedures against the threat of sea mines. The approach to the problem employs a magnetic vector potential in the frequency domain due to a pulse source electric dipole, and performs Laplace and Hankel transforms and integration along the cable, to describe the variation of the magnetic induction field due to an electric dipole of finite length. The result is applicable to shallow or deep sea water environments, adaptable to any transmitting current waveform and useful for wave-field separation. The prospects relate to a horizontal receiving coil at the sea bottom and simulate: a minesweeper campaign with a current source at the sea surface or a geophysical survey with a current source close to the sea floor. Therefore, the present analysis may serve: to define parameters in counter-sweeping of submarine mines; to map the conductivity of sediments under shallow waters for the prevention and control of contamination; and as a first approach in the characterization of offshore mineral and oil economic deposits.
Glycemic and lipidic profile in diabetic patients undergoing dialysis
Authors: Fortes Paulo Cezar , Mendes Jamille Godoy , Sesiuk Karoline , Marcondes Letícia Barros , Aita Carlos Alberto Mayora , Riella Miguel Carlos , Pecoits-Filho Roberto
Published: March 2017

OBJECTIVE: The aim of this study is to assess the clinical care pattern and to compare the lipid and glycemic profile in a group of diabetic patients undergoing both hemodialysis (HD) and peritoneal dialysis (PD) and to correlate these data using biomarkers of cardiovascular risk. SUBJECTS AND METHODS: The first phase consisted in performing a survey on demographic data, questions about the medical team and glycemic control. In the second phase, patients were assessed through laboratorial data on their glycemic and lipid profile at a single center for HD and PD. RESULTS: 91 patients was the total population; 70 patients (77%) answered the survey; 66 patients (94%) considered the nephrologist the physician responsible for caring for their glycemic control. Second phase: 59 patients were assessed, 29 undergoing HD and 30 undergoing PD. Fifty-seven percent of the patients had HbA1c above 7%; the level of glycemic markers in patients undergoing peritoneal dialysis was significantly higher than in patients undergoing hemodialysis: HbA1c (9.37 ± 0.5) vs. (7.37 ± 0.49) p < 0.01; fasting glycemia (170 ± 15) vs. (126 ± 15) mg/dL p < 0.05. We found a positive correlation between HbA1c and hyperfibrinogenemia (r = 0.4437, p < 0.0005). CONCLUSIONS: The data reveal that glycemic control in diabetic patients undergoing renal replacement therapy (RRT) is neglected. Peritoneal dialysis is related to the worst level of glycemic markers, possibly due to the glucose content in the dialysis solution, and higher levels from HbA1c have a positive correlation with hyperfibrinogenesis in this population.
A morphometric study of the intestinal mucosa of rats submitted to omentoenteropexy
Authors: Fernandez Pedro Muñoz , Pollachi Fabíola , Cordeiro Rafael Alves , Mader Ana Maria A. A , Catapani Wilson Roberto
Published: March 2017

CONTEXT: The omentoenteropexy technique was developed as an alternative method for intestinal neovascularization, due to the angiogenic properties of factors from the omentum. OBJECTIVES: This study investigated changes in intestinal villi heights and crypts depths due to surgical techniques: seromiotomy with and without omentoenteropexy. METHOD: Thirty rats were operated on, after being divided into three groups, namely GI, GII and GIII with 10 rats each. In the GI rats were submitted to omentoenteropexy; rats in GII were submitted only to a seromiotomy, and in the GIII only laparotomy. Sixty days after the first surgery, the animals were sacrificed and a segment of intestine was removed for histology using Masson's trichrome technique and morphometric study of intestinal mucosa. RESULTS: The histological findings showed that seromiotomy with or without omentoenteropexy increased the length of intestinal villi when compared with GIII (only laparotomy) (analysis of variance: P = 0.0068; GI 38.88 ± 4.17; GII 39.41± 6.33; GIII 31.85 ± 5.56; GI = GII P>0.05; GII>GIII P<0.05; GI>GIII P<0.001). CONCLUSION: No differences were demonstrated in relation to crypt depths between the groups (P = 0.60). Ongoing studies are being set forth by our group to add more data on the role of omentopexy as a tool to promote neovascularization and intestinal mucosal growth.
Descargas epileptiformes periódicas lateralizadas em neurocisticercose
Authors: Carvalho-Filho Pauzanes de , Arruda Orlando Martins , Melo-Souza Sebastião Eurico de
Published: March 2017

Relatamos o caso de menina (10 anos) que apresentava síndrome psicorgânica subaguda associada a cefaléia, sem sinais patentes de hipertensão intracraniana. O diagnóstico de neurocisticercose foi firmado com base no exame do LCR. Foi tratada com praziquantel (50 mg/kg/dia por 21 dias) e apresentou PLEDs sobre o hemisfério esquerdo no dia seguinte ao término do tratamento. Posteriormente, passou a apresentar sinais de disfunção córtico-subcortical desse mesmo lado, nos EEG subseqüentes. A TC inicialmente normal confirmou, com a evolução, maior comprometimento do hemisfério esquerdo, embora houvesse disseminação parenquimatosa bilateral de cisticercos. Respondeu bem ao tratamento e evoluiu com recuperação total dos sintomas. Discutimos, também, aspectos neurofisiológicos dessa anormalidade eletrencefalográfica.
Desmielinização tóxica do sistema nervoso central: II. Aspectos biológicos das células de Schwann observados durante o processo de reparação do tecido
Authors: Graça Dominguita Lühers
Published: March 2017

A droga gliotóxica brometo de etídio, Quando injetada localmente na medula espinhal do rato, induziu áreas de desmielinização que se desenvolveram em tempos diferentes de acordo com a dose empregada. Doses altas induziram lesões de desenvolvimento rápido (tipo I) e intermediárias (tipo III), enquanto doses baixas induziram lesões lentas (tipo II). Após o processo desmielinizante, os axônios desprovidos de suas bainhas de mielina foram remielinizados por oligodendrócitos ou células de Schwann (CS) dependendo de sua localização em áreas contendo ou não astrócitos, respectivamente. Na maioria das lesões, a área remielinizada pelas CS era proeminente. Nas lesões que repararam mais lentamente foi possível observar os fatores que influenciaram o comportamento dessas células dentro dos limites do sistema nervoso central. Após a invasão inicial a partir da superfície pial e dos espaços perivasculares, a expansão das CS dependeu da presença de matriz extracelular estável. Nas lesões de tipo I, esta matriz estava presente devido à natureza inflamatória do processo. Nas lesões de tipo II a matriz não ocorreu e as CS só podiam migrar entre os axônios desmie-lizados usando-os tal como uma passadeira. Entre as células contíguas podiam ser observadas fibras colágenas de diâmetro pequeno. Não foi evidenciada migração das CS ao longo dos axônios.