bluuebunny/crossref_metadata_2025 huggingface dataset:
Upper Cretaceous and Early Paleogene Smaller Calcareous Benthic Foraminifera from Cauvery Basin, Southeast India
Authors: Govindan Abiraman , Vijayan R.
Published: June 2019

Smaller calcareous benthic foraminiferal fauna consists of 198 species with observed stratigraphic ranges from upper Cretaceous to early Paleogene are documented from Cauvery Basin. One species has been described as new species. This compilation is based on well cutting samples of 17 exploratory wells from sub-surface litho units Kamalapuram Formation of early Eocene – Paleocene age and the underlying Porto Nova and Nannilam Formation of Maestrichtian – Campanian age. Several representatives of Nodosariids, Gyroidinoidids and Gavelinellids were found with extended stratigraphic ranges crossing K/T boundary. Nearly 40 benthic species became extinct at the end of Paleocene as reported among deep sea benthics elsewhere. The record of high diversity of benthic species, moderately high percentage of planktic forms associated with several of deep water organic walled agglutinated benthic species indicates sediments at this time interval are deep water shelf and slope deposits in the basin.
Comparative Evaluation of GIS Based Landslide Hazard Zonation Maps Using Different Approaches
Authors: Versain Laxmi Devi , Banshtu Rajeshwar Singh , Pandey Desh Deepak
Published: June 2019

Natural hazards like landslides in lesser Himalayan region of district Kullu (HP) India, owe to its typical geomorphic setting, variations in relief, precipitation during monsoon, thick forest cover, presence of glacier and glacial lakes along the higher reaches and various anthropogenic activities. Landslide locations, types and factor influencing the slope details are collected through the field visits and past record of landslides were used for development of inventory. Ancillary data are used for generation of different thematic layers (aspect, drainage density, geology, land cover, lineament density, relief, slope, and soil). Weight of evidence (WOE), information value(IV) and frequency ratio (FR) methods are used for generation of landslide hazard zonation (LHZ) maps which were classified into four zones namely high, moderate, low and very low. Validation and comparison of these hazard maps was done through the successive rate curve method which showed almost similar results, this proved the accuracy of these methods for generation of LHZ maps (WOE 80.01%, IV81.54% and frequency ratio 83.21%).
Microfacies and Depositional Environment of the Ilerdian Carbonates in the North-Western Tosya (SE Kastamonu) Region, Northern Turkey
Authors: Özgen-Erdem Nazire , Koç-Tasgin Calibe
Published: June 2019

Ilerdian (early Eocene) carbonates in the northwestern Tosya region, northern Turkey, are characterized by porcellaneous larger benthic foraminifera; Glomalveolina, Alveolina, Orbitolites, Opertorbitolites and Cyclopertorbitolites are common in the southeastern Kastamonu region, in facies deposited on a low-gradient carbonate ramp. The inner ramp comprises of Miliolid-soritid wackestone, Soritid wackestone, Alveolinid-soritid wackestone-packstone, Alveolinid wackestone, Alveolinid-Nummulitid wackestone-packstone, algal wackestone, and Coralline algal pack-grainstone microfacies. The middle ramp deposits are composed of Alveolinid-nummulitid wackestone-packstone and Nummulitid wackestone-packstone microfacies. Overall, the succession reflects a long term deepening trend.
Sequence Stratigraphic Interpretation of Late Cretaceous-Early Paleogene Sediments in the Central Part of Southern Anambra Basin, Nigeria
Authors: Onyekuru Samuel O. , Opara Alexander I. , Njoku Ikechukwu O. , Bassey Emmanuel O. , Ukaonu Cyril E.
Published: June 2019

The identification of additional hydrocarbon reserves to buffer pressure from increasing energy demands in Nigeria necessitated the application of sequence stratigraphic framework in the analysis of sedimentary successions in the central portion of southern Anambra basin. Wireline logs and biofacies data from three exploratory wells (S-1, S-2 and S-3) were used for the study. The stratigraphy of the study area observed from the three wells showed an overall regressive succession with short-lived transgressions. Lithofacies associations deduced from well log signatures defined four lithostratigraphic units: The Mamu and Ajali formations of kate Maastrichtian age; the Nsukka Formation of kate Maastrichtian - Danian age and Imo Formation of Paleocene age. The study further used the depositional sequence model to identify sequences and accompanying systems tracts that are bounded at the top and bottom by unconformities. Dating of identified key stratigraphic surfaces was achieved by correlating chronostratigraphic biofacies data to third order cycle charts. Correlation across the three wells highlighted spatial distributions of reservoirs and some useful stratigraphic and structural discontinuities that could form hydrocarbon traps. It also showed profitable stratigraphic surfaces that would aid basin-wide correlation for improved horizon(s) mapping and hydrocarbon prospectivity in the Anambra basin. Erosional unconformities identified in the wells that correlated with major drops in global sea level, fingerprinted the influence of eustacy on sedimentation and sequence development. Other factors such as subsidence and sediment supply have direct relationships to the identified structures (faults) which also initiated the accommodation created for sedimentation in the study area.
FM-to-AM conversion in angular filtering based on transmitted volume Bragg gratings
Authors: Gao Fan , Xiong Baoxing , Zhang Xiang , Yuan Xiao
Published: June 2019

FM-to-AM conversion for angular filtering based on transmitted volume Bragg gratings (TBGs) is discussed. Simulation results show that a narrower spectral selectivity of TBGs led to stronger FM-to-AM conversion. Good angular selectivity and a wide bandwidth for the TBGs can be obtained by controlling the grating period and thickness. FM-to-AM conversion can be effectively suppressed and the distortion criterion for the filtered beam reduces to less than 5%. FM-to-AM conversion of TBGs is demonstrated in the ‘Shenguang’ facility, and the results are in good agreement with the simulation.
The effect of an unsteady flow incident on an array of circular cylinders
Authors: Klettner C. A. , Eames I. , Hunt J. C. R.
Published: June 2019

In this paper we investigate the effect of an inhomogeneous and unsteady velocity field incident on an array of rigid circular cylinders arranged within a circular perimeter (diameter $D_{G}$) of varying solid fraction $\unicode[STIX]{x1D719}$, where the unsteady flow is generated by placing a cylinder (diameter $D_{G}$) upwind of the array. Unsteady two-dimensional viscous simulations at a moderate Reynolds number ($Re=2100$) and also, as a means of extrapolating to a flow with a very high Reynolds number, inviscid rapid distortion theory (RDT) calculations were carried out. These novel RDT calculations required the circulation around each cylinder to be zero which was enforced using an iterative method. The two main differences which were highlighted was that the RDT calculations indicated that the tangential velocity component is amplified, both, at the front and sides of the array. For the unsteady viscous simulations this result did not occur as the two-dimensional vortices (of similar size to the array) are deflected away from the boundary and do not penetrate into the boundary layer. Secondly, the amplification is greater for the RDT calculations as for the unsteady finite Reynolds number calculations. For the two highest solid fraction arrays, the mean flow field has two recirculation regions in the near wake of the array, with closed streamlines that penetrate into the array which will have important implications for scalar transport. The increased bleed through the array at the lower solid fraction results in this recirculation region being displaced further downstream. The effect of inviscid blocking and viscous drag on the upstream streamwise velocity and strain field is investigated as it directly influences the ability of the large coherent structures to penetrate into the array and the subsequent forces exerted on the cylinders in the array. The average total force on the array was found to increase monotonically with increasing solid fraction. For high solid fraction $\unicode[STIX]{x1D719}$, although the fluctuating forces on the individual cylinders is lower than for low $\unicode[STIX]{x1D719}$, these forces are more correlated due to the proximity of the cylinders. The result is that for mid to high solid fraction arrays the fluctuating force on the array is insensitive to $\unicode[STIX]{x1D719}$. For low $\unicode[STIX]{x1D719}$, where the interaction of the cylinders is weak, the force statistics on the individual cylinders can be accurately estimated from the local slip velocity that occurs if the cylinders were removed.
Fractal sets of neutral curves for stably stratified plane Couette flow
Authors: Healey Jonathan J.
Published: June 2019

The linear stability of plane Couette flow is investigated when the plates are horizontal, and the fluid is stably stratified with a cubic basic density profile. The disturbances are treated as inviscid and diffusion of the density field is neglected. Previous studies have shown that this density profile can develop multiple neutral curves, despite the stable stratification, and the fact that plane Couette flow of homogeneous fluid is stable. It is shown that when the neutral curves are plotted with wave angle on one axis, and location of the density inflexion point on the other axis, they produce a self-similar fractal pattern. The repetition on smaller and smaller scales occurs in the limit when the waves are highly oblique, i.e. longitudinal vortices almost aligned with the flow; the corresponding limit for two-dimensional waves is that of strong buoyancy/weak flow. The fractal set of neutral curves also represents a fractal of bifurcation points at which nonlinear solutions can be continued from the trivial state, and these may be helpful for understanding turbulent states. This may be the first example of a fractal generated by a linear ordinary differential equation.
Richtmyer–Meshkov instability on a quasi-single-mode interface
Authors: Liang Yu , Zhai Zhigang , Ding Juchun , Luo Xisheng
Published: June 2019

Experiments on Richtmyer–Meshkov instability of quasi-single-mode interfaces are performed. Four quasi-single-mode air/$\text{SF}_{6}$ interfaces with different deviations from the single-mode one are generated by the soap film technique to evaluate the effects of high-order modes on amplitude growth in the linear and weakly nonlinear stages. For each case, two different initial amplitudes are considered to highlight the high-amplitude effect. For the single-mode and saw-tooth interfaces with high initial amplitude, a cavity is observed at the spike head, providing experimental evidence for the previous numerical results for the first time. For the quasi-single-mode interfaces, the fundamental mode is the dominant one such that it determines the amplitude linear growth, and subsequently the impulsive theory gives a reasonable prediction of the experiments by introducing a reduction factor. The discrepancy in linear growth rates between the experiment and the prediction is amplified as the quasi-single-mode interface deviates more severely from the single-mode one. In the weakly nonlinear stage, the nonlinear model valid for a single-mode interface with small amplitude loses efficacy, which indicates that the effects of high-order modes on amplitude growth must be considered. For the saw-tooth interface with small amplitude, the amplitudes of the first three harmonics are extracted from the experiment and compared with the previous theory. The comparison proves that each initial mode develops independently in the linear and weakly nonlinear stages. A nonlinear model proposed by Zhang & Guo (J. Fluid Mech., vol. 786, 2016, pp. 47–61) is then modified by considering the effects of high-order modes. The modified model is proved to be valid in the weakly nonlinear stage even for the cases with high initial amplitude. More high-order modes are needed to match the experiment for the interfaces with a more severe deviation from the single-mode one.
JOINT DIAMONDS AND LAVER DIAMONDS
Authors: HABIČ MIHA E.
Published: June 2019

The concept of jointness for guessing principles, specifically ${\diamondsuit _\kappa }$ and various Laver diamonds, is introduced. A family of guessing sequences is joint if the elements of any given sequence of targets may be simultaneously guessed by the members of the family. While equivalent in the case of ${\diamondsuit _\kappa }$, joint Laver diamonds are nontrivial new objects. We give equiconsistency results for most of the large cardinals under consideration and prove sharp separations between joint Laver diamonds of different lengths in the case of θ-supercompact cardinals.
Do socio-demographic and anthropometric characteristics predict food choice motives in an Irish working population?
Authors: Schliemann Désirée , Woodside Jayne V. , Geaney Fiona , Cardwell Chris , McKinley Michelle C. , Perry Ivan
Published: June 2019

Dietary behaviour is influenced by a complex web of biological, psychological, physiological, social, economic and cultural factors. Understanding socio-demographic and anthropometric characteristics that influence food choice may be important in guiding dietary interventions. The present study aimed to identify whether socio-demographic and anthropometric characteristics influence food choice in an Irish working population. A cross-sectional survey was conducted in 2014 as part of the Food Choice at Work Study, a large clustered non-randomised, controlled trial based in county Cork, Ireland. Information regarding food motives was collected at the 3–4 months follow-up. The ‘Food Choice Questionnaire’ was used to measure food motives. Multiple linear regression was conducted to test the association between socio-demographic and anthropometric characteristics (age, sex, BMI, education, type of accommodation, living situation, marital status, parental status) and worksite and food motives. A total of 678 employees were included in the analysis. Overall, only a small percentage of food choice was influenced by the characteristics included in this analysis (1·6 to 8·8 %). Sensory appeal and satisfaction were scored most important by all sub-populations. Sex was most often associated with differences in food motives (i.e. all food motives except for familiarity and ethical concern were significantly more important to females compared with males; P = 0·001/P < 0·001). Worksite, age, BMI and marital status also seemed to play a small role in influencing food choice. The results show that food choice is complex and not easily explained by differences in socio-demographic or anthropometric population characteristics.
Models for the rates of pupal development, fat consumption and mortality in tsetse (Glossinaspp)
Authors: Hargrove J.W. , Vale G.A.
Published: June 2019

Environmental temperature is an important driver of the population dynamics of tsetse (Glossinaspp) because the fly's immature stages are particularly vulnerable to temperatures (T) outside the rangeT= 16–32°C. Laboratory experiments carried out 50 years ago provide extensive measures of temperature-dependent rates of development, fat consumption and mortality in tsetse pupae. We improve on the models originally fitted to these data, providing better parameter estimates for use in population modelling. A composite function accurately models rates of pupal development forT= 8–32°C. Pupal duration can be estimated by summing the temperature-dependent daily percentage of development completed. Fat consumption is modelled as a logistic function of temperature; the total fat consumed during pupal development takes a minimum forT≈ 25°C. Pupae experiencing constant temperatures <16°C exhaust their fat reserves before they complete development. At high temperatures, direct effects kill the pupae before fat stores are exhausted. The relationship between pupal mortality and temperature is well described by the sum of two exponential functions. Summing daily mortality rates over the whole pupal period does not reliably predict overall mortality. Mortality is more strongly correlated with the mean temperature experienced over pupal life or, forT≤ 30°C, the fat consumption during this period. The new results will be particularly useful in the construction of various models for tsetse population dynamics, and will have particular relevance for agent-based models where the lives of individual tsetse are simulated using a daily time step.
Beyond the epistaxis: voluntary nasal leech (Dinobdella ferox) infestation revealed the leech behaviours and the host symptoms through the parasitic period
Authors: Lai Yi-Te
Published: June 2019

Dinobdella ferox is the most reported and studied leech species parasitizing mammalian mucus membranes. However, our knowledge of D. ferox during parasitizing and its effects on hosts has remained limited. To investigate the behaviour of D. ferox in the parasitic period and the subsequent host symptoms, the author was infested voluntarily with three juvenile leeches under regularly-conducted examinations of complete blood count (CBC) and nasal endoscopy (NE). After the first head protrusion of the parasitizing leech at the host nostril, the occurrence of bleeding-related symptoms decreased and ceased completely weeks before the end of the parasitic period. Negligible impacts of the parasitizing leech on the host were shown by CBCs, and a parasitizing leech was able to hide from NE despite being so large it at times protrudes out of the host nostril. Finally, parasitizing D. ferox were coaxed to emerge at the nostril by water only after their first head protrusion, indicating that non-invasive removal of parasitizing D. ferox before head protrusion might be difficult. Through the voluntary infestation, the full documentation of behaviours of D. ferox in the parasitic period and host symptoms shown in this study will promote better diagnoses and treatments of nasal leech infestation.
Health Technology Assessment in Thailand: Institutionalization and Contribution to Healthcare Decision Making: Review of Literature
Authors: Leelahavarong Pattara , Doungthipsirikul Suradech , Kumluang Suthasinee , Poonchai Akanittha , Kittiratchakool Nitichen , Chinnacom Danai , Suchonwanich Netnapis , Tantivess Sripen
Published: June 2019

Objectives

To explore health technology assessment (HTA) in Thailand focusing on its institutionalization, key elements for HTA introduction, and HTA contribution to policy.

Methods

A review of literature covered a wide range of topics, including the institutionalization of HTA, elements of HTA introduction, and the role of HTA in policy decision making in Thai context. Additional information from the authors’ involvement in the policy decision-making process in Thailand was also considered.

Results

HTA institutionalization comprises processes of introducing HTA, including evidence generation and use in policymaking, building capacity of HTA practitioners, organizations, system infrastructure, and collaborations. In Thailand, HTA has been formally integrated into coverage decisions, including in the development of the National List of Essential Medicines and the Universal Health Coverage Scheme benefits package. Contributing factors included political will and leadership, capacity building on HTA-related disciplines, adequate resources, technical expertise, and data. Conversely, challenges faced included the absence of a governing body and strategic plan for HTA systems development, a lack of formal mechanisms for mobilizing financial support, an inadequate number of HTA researchers in nonprofit institutes, and the rise in advanced biotechnologies.

Conclusions

HTA plays an important role in evidence-based healthcare decision making. However, key elements of HTA institutionalization need to be strengthened, especially governance structure and policy for HTA systems development, building and retaining capacity of HTA practitioners to meet demand, addressing the challenges of complex and highly innovative health interventions. Lessons learned from the Thai experience may be used as guidance for HTA institutionalization in other developing countries.
Individual differences in non-adjacent statistical dependency learning in infants
Authors: LANY Jill , SHOAIB Amber
Published: June 2019

There is considerable controversy over the factors that shape infants’ developing knowledge of grammar. Work with artificial languages suggests that infants’ ability to track statistical regularities within the speech they hear could, in principle, support grammatical development. However, little work has tested whether infants’ performance on laboratory tasks reflects factors that are relevant in real-world language learning. Here we tested whether the language that infants hear at home, and their receptive language skills, predict their performance on tasks assessing the ability to learn non-adjacent statistical dependencies (NADs) at 15 months, and whether that in turn predicts sensitivity to native-language NADs at 18 months. We found evidence for some (though not all) of these relations, and primarily for females. The results suggest that performance on the artificial language-learning task reveals something about the mechanisms of grammatical development, and that females and males may be learning NADs differently.
Exploring the Value–Action Gap through Shared Values, Capabilities and Deforestation Behaviours in Guatemala
Authors: Robb Jane , Haggar Jeremy , Lamboll Richard , Castellanos Edwin
Published: June 2019

Understanding drivers of deforestation is essential for developing any successful intervention to reduce forest degradation or loss, yet there remains relatively little consensus or clarity on how drivers should be identified and classified. To capture the full range of values and mediating factors that may contribute to land-use behaviours, an approach derived from a shared values perspective that includes a range of values associated with whole landscapes and ecosystems is required. We developed a model that combines behavioural theory with the Capability Approach as a conceptual framework through which to investigate the value–action gap. We used exploratory factor analysis (EFA) of Likert-scale responses to belief statements in order to identify land users’ shared values in the Sarstún Motagua region of Guatemala. We then qualify and quantify the role of capabilities in mediating between the shared values of different cultural groups of land users (Q’eqchi Maya and Ladinos) by comparing their factor scores with their self-reported forest cover change behaviours. Our results indicate that Maya and Ladinos share a set of values, but hold different value orientations that predict their behavioural intentions. We find that their different value orientations reflect behavioural intentions, but an understanding of the capabilities available to different groups is also necessary to fill the value–action gap. These findings have implications for behavioural theory, providing empirical links between shared values, capabilities and behaviour and identification of the role of value orientations, as well as demonstrating a useful approach for decision-makers seeking to understand drivers of change at landscape and whole-ecosystem levels.
A longitudinal study to investigate previousChlamydia trachomatisinfection as a risk factor for subsequent anorectal infection in men who have sex with men (MSM) and women visiting STI clinics in the Netherlands
Authors: Leenen J. , van Liere G.A.F.S. , Hoebe C.J.P.A. , Hogewoning A.A. , de Vries H.J.C. , Dukers-Muijrers N.H.T.M.
Published: June 2019

Although anorectalChlamydia trachomatis(CT) infections are frequently diagnosed in men who have sex with men (MSM) and women, the reason for this infection often remains unexplained, as anal sex is not always reported. Oropharyngeal infections inoculating the gastrointestinal (GI) tract may contribute to anorectal-CT infections, as evidence in animals suggests that chlamydia bacteria undergo GI passage; however, no evidence exists in humans. Longitudinal patient clinic-registry data from MSM (n= 17 125) and women (n= 4120) from two Dutch sexually transmitted infection clinics were analysed. When adjusting for confounding socio-demographics, co-infections and risk behaviour, previous (from 3 weeks up to 24 months) oropharyngeal CT was not a risk factor for subsequent anorectal CT in women (odds ratio (OR) 0.46; 95% confidence interval (CI) 0.18–1.18;P= 0.11) and MSM (OR 1.33; 95% CI 0.86–2.07;P= 0.204). Despite the large dataset, the numbers did not allow for the estimation of risk in specific subgroups of interest. The role of the GI tract cannot be excluded with this epidemiological study, but the impact of preceding oropharyngeal CT on anorectal-CT infection is likely limited.
Local Experiences and the Second World War: New Perspectives on Mass Violence in Mid-Twentieth Century Europe
Authors: Erdeljac Filip
Published: June 2019

The extensive attention that Timothy Snyder’sBloodlands: Europe Between Hitler and Stalinhas attracted since its publication in 2010 has raised our overall awareness of the structural might that the Soviet Union and Nazi Germany displayed as they reshaped the territories that had separated the two states during the interwar period. In addition to earning widespread acclaim, the volume has been widely criticised by scholars who have exposed the extent to which non-German populations in Eastern Europe participated in the violent persecution of unwanted minority communities during the Second World War. Jan Gross, whoseNeighborsunearthed that the Poles of Jedwabne murdered their Jewish neighbours without significant prompting from the German occupiers, has argued that Snyder deprives the inhabitants of his ‘bloodlands’ of agency by blaming wartime violence in the region almost exclusively on Hitler, Stalin and their overlapping policies of state destruction. The evident tensions between micro-historical approaches that stress the importance of local agency and macro-level analyses of larger geographical spaces have obscured how profoundly the interplay of broader structural factors and local variables shaped the course of the Second World War in different locations. Four recent micro-historical works help to partially reconcile the two seemingly oppositional approaches by providing new frameworks for thinking about the complex interactions that occurred between smaller groups of people and the broader forces that shaped their lives during the 1930s and 1940s. The four volumes show that global, national, regional and local agendas overlapped to make ordinary people reconfigure how they saw themselves and how they interpreted the world around them. The identities and perceptions that emerged from these interactions enhance our understanding of the multiple factors that determined people’s actions during the Second World War and the Holocaust.
Approximation algorithms in combinatorial scientific computing
Authors: Pothen Alex , Ferdous S. M. , Manne Fredrik
Published: June 2019

We survey recent work on approximation algorithms for computing degree-constrained subgraphs in graphs and their applications in combinatorial scientific computing. The problems we consider include maximization versions of cardinality matching, edge-weighted matching, vertex-weighted matching and edge-weighted$b$-matching, and minimization versions of weighted edge cover and$b$-edge cover. Exact algorithms for these problems are impractical for massive graphs with several millions of edges. For each problem we discuss theoretical foundations, the design of several linear or near-linear time approximation algorithms, their implementations on serial and parallel computers, and applications. Our focus is on practical algorithms that yield good performance on modern computer architectures with multiple threads and interconnected processors. We also include information about the software available for these problems.
Processing level and diet quality of the US grocery cart: is there an association?
Authors: Juul Filippa , Simões Bárbara dos Santos , Litvak Jacqueline , Martinez-Steele Euridice , Deierlein Andrea , Vadiveloo Maya , Parekh Niyati
Published: June 2019

Objective:

The majority of groceries purchased by US households are industrially processed, yet it is unclear how processing level influences diet quality. We sought to determine if processing level is associated with diet quality of grocery purchases.

Design:

We analysed grocery purchasing data from the National Household Food Acquisition and Purchase Survey 2012–2013. Household grocery purchases were categorized by the NOVA framework as minimally processed, processed culinary ingredients, processed foods or ultra-processed foods. The energy share of each processing level (percentage of energy; %E) and Healthy Eating Index-2015 (HEI-2015) component and total scores were calculated for each household’s purchases. The association between %E from processed foods and ultra-processed foods, respectively, and HEI-2015 total score was determined by multivariable linear regression. Foods purchased by households with the highest v. lowest ultra-processed food purchases and HEI-2015 total score <40 v. ≥60 were compared using linear regression.

Setting:

USA.

Participants:

Nationally representative sample of 3961 households.

Results:

Processed foods and ultra-processed foods provided 9·2 (se 0·3) % and 55·8 (se 0·6) % of purchased energy, respectively. Mean HEI-2015 score was 54·7 (se 0·4). Substituting 10 %E from minimally processed foods and processed culinary ingredients for ultra-processed foods decreased total HEI-2015 score by 1·8 points (β = −1·8; 95 % CI −2·0, −1·5). Processed food purchases were not associated with diet quality. Among households with high ultra-processed food purchases, those with HEI-2015 score <40 purchased less minimally processed plant-foods than households with HEI-2015 score ≥60.

Conclusions:

Increasing purchases of minimally processed foods, decreasing purchases of ultra-processed foods and selecting healthier foods at each processing level may improve diet quality.
Expressive Voting in Autocracies: A Theory of Non-Economic Participation with Evidence from Cameroon
Authors: Letsa Natalie Wenzell
Published: June 2019

Why do people vote in autocratic elections? Until now, most answers to this question have argued that people vote because they expect a material reward, such as patronage or a direct transfer via vote-buying, or as a way of rewarding the regime for its economic performance. I argue that citizens also vote for different non-economic, expressive reasons, such as a sense of civic duty or a desire to improve the democratic process. I present data from an original quasi-national public-opinion survey conducted in Cameroon, which shows that expressive reasons for voting can explain more variation in voting behavior than economic reasons. These different motivations challenge the implications of existing models of democratization by explaining how some of the poorest electoral autocracies have withstood decades of economic stagnation.
Reactive vs structural approach: A public law response to populism
Authors: ALTERIO ANA MICAELA
Published: June 2019

Contemporary scholarship mainly focuses on the crisis of political representation as the key facilitator behind the emergence of populism. If so, populism urges public law to revisit and rethink institutional designs. This article addresses two possible responses to populism. On one hand, an intuitive response could be to hamper popular participation by avoiding plebiscites, referendums or any other kind of public consultation. Alternatively, it is possible to respond to populism from a structural point of view. In my opinion, to resist populism public law should take into account the lack of responsiveness and accountability of representative systems. The article puts forward a proposal in that direction; it advances a response to populism consisting of new institutional systems that generate strong participatory mechanisms to incorporate ‘the popular’. In doing so, the article uses the new Latin American Constitutionalism as an example of both the potentialities and difficulties of designing institutional systems in public law. In the wake of rising populism, it contributes to the existing debate by criticising populism and its constitutional expression, as well as developing arguments in favour of popular constitutionalism.
Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia
Authors: Giménez Neus , Schulz Ralph , Higashi Morihiro , Aymerich Marta , Villamor Neus , Delgado Julio , Juan Manel , López-Guerra Mònica , Campo Elias , Rosich Laia , Seiffert Martina , Colomer Dolors
Published: June 2019

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses. Recruitment and subsequent activation of IRAK4 upon TLR stimulation is mediated by the myeloid differentiation primary response 88 (MYD88) adaptor protein. Around 3% of chronic lymphocytic leukemia (CLL) patients have activating mutations ofMYD88, a driver mutation in this disease. Here, we studied the effects of TLR activation and the pharmacological inhibition of IRAK4 with ND2158, an IRAK4 competitive inhibitor, as a therapeutic approach in CLL. Our in vitro studies demonstrated that ND2158 preferentially killed CLL cells in a dose-dependent manner. We further observed a decrease in NF-κB and STAT3 signaling, cytokine secretion, proliferation and migration of primary CLL cells fromMYD88-mutated and -unmutated cases. In theEµ-TCL1 adoptive transfer mouse model of CLL, ND2158 delayed tumor progression and modulated the activity of myeloid and T cells. Our findings show the importance of TLR signaling in CLL development and suggest IRAK4 as a therapeutic target for this disease.
Therapeutic effects of a novel BAFF blocker on arthritis
Authors: Zhou Bailing , Zhang Hailong , Su Xiaoqing , Luo Yi , Li Xiaopeng , Yu Chaoheng , Xie Qibing , Xia Xuyang , He Gu , Yang Li
Published: June 2019

B-cell targeted therapy is effective for autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis (RA), although there are setbacks in RA clinical trials. In this study, we designed a novel B-cell activating factor (BAFF) antagonist: BAFF-Trap, a recombinant glycoprotein with BAFF-binding domains of two BAFF receptors (TACI and Br3) linked to Fc domain of human IgG1. Unlike TACI-Fc, BAFF-Trap bound BAFF but not APRIL (a proliferation-inducing ligand), and significantly suppressed the development of collagen-induced arthritis and adjuvant-induced arthritis. Furthermore, BAFF-Trap inhibited proinflammatory cytokine expression, ameliorated joint damage and suppressed B- and T-cell activation. BAFF-Trap reduced dendritic cells in joints, and increased regulatory T cell, regulatory B-cell, and M2 macrophage. The function of BAFF-Trap was related to inhibition of canonical and noncanonical NF-κB activation. Thus, BAFF-Trap may be a valuable agent for the effective treatment of RA.
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
Authors: Zhang Wei , Yang Si-Lu , Yang Mei , Herrlinger Stephanie , Shao Qiang , Collar John L. , Fierro Edgar , Shi Yanhong , Liu Aimin , Lu Hui , Herring Bruce E. , Guo Ming-Lei , Buch Shilpa , Zhao Zhen , Xu Jian , Lu Zhipeng , Chen Jian-Fu
Published: June 2019

Primary microcephaly is caused by mutations in genes encoding centrosomal proteins including WDR62 and KIF2A. However, mechanisms underlying human microcephaly remain elusive. By creating mutant mice and human cerebral organoids, here we found that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells (NPCs), including outer radial glia (oRG). WDR62 ablation led to retarded cilium disassembly, long cilium, and delayed cell cycle progression leading to decreased proliferation and premature differentiation of NPCs. Mechanistically, WDR62 interacts with and promotes CEP170’s localization to the basal body of primary cilium, where CEP170 recruits microtubule-depolymerizing factor KIF2A to disassemble cilium. WDR62 depletion reduced KIF2A’s basal body localization, and enhanced KIF2A expression partially rescued deficits in cilium length and NPC proliferation. Thus, modeling microcephaly with cerebral organoids and mice reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly, disruption of which contributes to microcephaly.
Layer-specific integration of locomotion and sensory information in mouse barrel cortex
Authors: Ayaz Aslı , Stäuble Andreas , Hamada Morio , Wulf Marie-Angela , Saleem Aman B. , Helmchen Fritjof
Published: June 2019

During navigation, rodents continually sample the environment with their whiskers. How locomotion modulates neuronal activity in somatosensory cortex, and how it is integrated with whisker-touch remains unclear. Here, we compared neuronal activity in layer 2/3 (L2/3) and L5 of barrel cortex using calcium imaging in mice running in a tactile virtual reality. Both layers increase their activity during running and concomitant whisking, in the absence of touch. Fewer neurons are modulated by whisking alone. Whereas L5 neurons respond transiently to wall-touch during running, L2/3 neurons show sustained activity. Consistently, neurons encoding running-with-touch are more abundant in L2/3 and they encode the run-speed better during touch. Few neurons across layers were also sensitive to abrupt perturbations of tactile flow during running. In summary, locomotion significantly enhances barrel cortex activity across layers with L5 neurons mainly reporting changes in touch conditions and L2/3 neurons continually integrating tactile stimuli with running.
Atomic-resolution imaging of surface and core melting in individual size-selected Au nanoclusters on carbon
Authors: Foster D. M. , Pavloudis Th. , Kioseoglou J. , Palmer R. E.
Published: June 2019

Although the changes in melting behaviour on the nanoscale have long attracted the interest of researchers, the mechanism by which nanoparticles melt remains an open problem. We report the direct observation, at atomic resolution, of surface melting in individual size-selected Au clusters (2–5 nm diameter) supported on carbon films, using an in situ heating stage in the aberration corrected scanning transmission electron microscope. At elevated temperatures the Au nanoparticles are found to form a solid core-liquid shell structure. The cluster surface melting temperatures, show evidence of size-dependent melting point suppression. The cluster core melting temperatures are significantly greater than predicted by existing models of free clusters. To explore the effect of the interaction between the clusters and the carbon substrate, we employ a very large-scale ab initio simulation approach to investigate the influence of the support. Theoretical results for surface and core melting points are in good agreement with experiment.
Deep data analytics for genetic engineering of diatoms linking genotype to phenotype via machine learning
Authors: Trofimov Artem A. , Pawlicki Alison A. , Borodinov Nikolay , Mandal Shovon , Mathews Teresa J. , Hildebrand Mark , Ziatdinov Maxim A. , Hausladen Katherine A. , Urbanowicz Paulina K. , Steed Chad A. , Ievlev Anton V. , Belianinov Alex , Michener Joshua K. , Vasudevan Rama , Ovchinnikova Olga S.
Published: June 2019

Genome engineering for materials synthesis is a promising avenue for manufacturing materials with unique properties under ambient conditions. Biomineralization in diatoms, unicellular algae that use silica to construct micron-scale cell walls with nanoscale features, is an attractive candidate for functional synthesis of materials for applications including photonics, sensing, filtration, and drug delivery. Therefore, controllably modifying diatom structure through targeted genetic modifications for these applications is a very promising field. In this work, we used gene knockdown in Thalassiosira pseudonana diatoms to create modified strains with changes to structural morphology and linked genotype to phenotype using supervised machine learning. An artificial neural network (NN) was developed to distinguish wild and modified diatoms based on the SEM images of frustules exhibiting phenotypic changes caused by a specific protein (Thaps3_21880), resulting in 94% detection accuracy. Class activation maps visualized physical changes that allowed the NNs to separate diatom strains, subsequently establishing a specific gene that controls pores. A further NN was created to batch process image data, automatically recognize pores, and extract pore-related parameters. Class interrelationship of the extracted paraments was visualized using a multivariate data visualization tool, called CrossVis, and allowed to directly link changes in morphological diatom phenotype of pore size and distribution with changes in the genotype.
Supplying a pharmacy for NASA exploration spaceflight: challenges and current understanding
Authors: Blue Rebecca S. , Bayuse Tina M. , Daniels Vernie R. , Wotring Virginia E. , Suresh Rahul , Mulcahy Robert A. , Antonsen Erik L.
Published: June 2019

In order to maintain crew health and performance during long-duration spaceflight outside of low-Earth orbit, NASA and its international partners must be capable of providing a safe and effective pharmacy. Given few directed studies of pharmaceuticals in the space environment, it is difficult to characterize pharmaceutical effectiveness or stability during spaceflight; this in turn makes it challenging to select an appropriate formulary for exploration. Here, we present the current state of literature regarding pharmaceutical stability, metabolism, and effectiveness during spaceflight. In particular, we have attempted to highlight the gaps in current knowledge and the difficulties in translating terrestrial-based drug studies to a meaningful interpretation of drug stability, safety, and effectiveness in space. We hope to identify high-yield opportunities for future research that might better define and mitigate pharmaceutical risk for exploration missions.
Spending at least 120 minutes a week in nature is associated with good health and wellbeing
Authors: White Mathew P. , Alcock Ian , Grellier James , Wheeler Benedict W. , Hartig Terry , Warber Sara L. , Bone Angie , Depledge Michael H. , Fleming Lora E.
Published: June 2019

Spending time in natural environments can benefit health and well-being, but exposure-response relationships are under-researched. We examined associations between recreational nature contact in the last seven days and self-reported health and well-being. Participants (n = 19,806) were drawn from the Monitor of Engagement with the Natural Environment Survey (2014/15–2015/16); weighted to be nationally representative. Weekly contact was categorised using 60 min blocks. Analyses controlled for residential greenspace and other neighbourhood and individual factors. Compared to no nature contact last week, the likelihood of reporting good health or high well-being became significantly greater with contact ≥120 mins (e.g. 120–179 mins: ORs [95%CIs]: Health = 1.59 [1.31–1.92]; Well-being = 1.23 [1.08–1.40]). Positive associations peaked between 200–300 mins per week with no further gain. The pattern was consistent across key groups including older adults and those with long-term health issues. It did not matter how 120 mins of contact a week was achieved (e.g. one long vs. several shorter visits/week). Prospective longitudinal and intervention studies are a critical next step in developing possible weekly nature exposure guidelines comparable to those for physical activity.
Effects of maize rotation on the physicochemical properties and microbial communities of American ginseng cultivated soil
Authors: Jiao Xiao-Lin , Zhang Xue-Song , Lu Xiao-Hong , Qin Ruijun , Bi Yan-Meng , Gao Wei-Wei
Published: June 2019

The production of American ginseng (Panax quinquefolius L.) is severely limited by the replant disorders in China. Crop rotation with maize might reduce the replant problems, but little information is available on the effect of maize rotation on soil cultivated with ginseng. In this study, we analyzed nutrients, phenolic acids, and microbial communities in soils from the fields with continuous maize, mono-culture ginseng, and 1-, 3-, and 5-year maize rotation after ginseng. Pot experiments were also conducted to evaluate the performance of replanting ginseng in these soils. The results showed that Mn, Cu, and 5 phenolic acids in ginseng-cultivated soil were significantly decreased by maize rotation. A 5-year maize rotation significantly increased the relative abundance of beneficial soil bacteria, such as Arthrobacter, rather than decreasing the abundances of potential pathogenic genera. Clustering analysis revealed that the physicochemical properties and microbial communities of 3- and 5-year maize rotation soil were more similar to CM than to G soil. The biomass of replanted ginseng root was improved, and root disease was reduced over 3 years of maize rotation. Overall, the results showed that at least a 3-year maize rotation is needed to overcome the replant failure of American ginseng.
Precisely Endowing Colloidal Particles with Silica Branches
Authors: Zhao Bin , Li Dongzhi , Long Yue , Song Kai
Published: June 2019

A method to modify colloidal particles with silica rods in a water/n-pentanol system is reported here. Because of the interfacial tension between aqueous and n-pentanol phase, water which surrounds the colloidal particles de-wets into droplets during the deposition process of silica. As a result of unidirectional deposition, silica rods grow perpendicularly on the surface of the colloidal particles at the site of the smallest curvature where the water droplet has been de-wetted. By controlling the hydrolysis conditions, particles with certain number of branches or rambutan-like particles can be obtained. This approach opens a path towards the higher levels of colloidal complexity.
The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection
Authors: Foulsham William , Mittal Sharad K. , Nakao Takeshi , Coco Giulia , Taketani Yukako , Chauhan Sunil K. , Dana Reza
Published: June 2019

Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor antagonist oxidized ATP (oATP). Corneal transplantation was performed using C57BL/6 donors and BALB/c hosts. oATP or sterile saline was administered via intraperitoneal injection for 2 weeks postoperatively. Frequencies of CD45+ leukocytes, CD11b+MHCII+ antigen presenting cells (APCs), CD4+IFN-γ+ effector Th1 cells and CD4+Foxp3+ regulatory T cells (Tregs) were evaluated by flow cytometry. Slit-lamp microscopy was performed weekly for 8 weeks to evaluate graft opacity and determine transplant rejection. Treatment with oATP was shown to significantly reduce graft infiltration of CD45+ leukocytes, decrease APC maturation and suppress effector Th1 cell generation relative to saline-treated control. No difference in Treg frequencies or Foxp3 expression was observed between the oATP-treated and control groups. Finally, oATP treatment was shown to reduce graft opacity and increase graft survival. This report demonstrates that oATP limits the alloimmune response by regulating APC maturation and suppressing the generation of alloreactive Th1 immunity.