bluuebunny/crossref_metadata_2025 huggingface dataset:
Peculiarities of Functional Connectivity—including Cross-Modal Patterns—in Professional Karate Athletes: Correlations with Cognitive and Motor Performances
Authors: Berti Beatrice , Momi Davide , Sprugnoli Giulia , Neri Francesco , Bonifazi Marco , Rossi Alessandro , Muscettola Maria M. , Benocci Roberto , Santarnecchi Emiliano , Rossi Simone
Published: June 2019

Professional karate is a sport activity requiring both physical and psychological skills that have been associated with a better “global neural efficacy.” By means of resting state functional magnetic resonance imaging (rs-fMRI), we investigated the neural correlates of cognitive and kinematic abilities in a group of 14 professional karateka and 14 heathy matched controls. All subjects underwent an extensive cognitive test battery for the identification of individual multidimensional cognitive profile and rs-fMRI scans investigating functional connectivity (FC). Moreover, kinematic performances in athletes were quantified by the Ergo-Mak, an integrated system developed for measuring motor reactivity, strength, and power of athletic gestures. Karateka performed significantly better than controls in the visual search task, an ability linked with increased positive correlations in FC between the right superior parietal lobe and bilateral occipital poles. Kinematic performances of athletic feats were sustained by increased positive correlations between subcortical (cerebellum and left thalamus) and cortical (inferior frontal cortex, superior parietal cortex, superior temporal cortex) regions. An unexpected FC increase between auditory and motor-related areas emerged in karateka, possibly reflecting a cross-modal coupling due to the continuous exposure to either internal or external auditory cues, positing this sensory channel as a possible target for novel training strategies. Results represent a further step in defining brain correlates of “neural efficiency” in these athletes, whose brain can be considered a model of continuous plastic train-related adaptation.
Adsorptive Applications of Montmorillonite Clay for the Removal of Ag(I) and Cu(II) from Aqueous Medium
Authors: Alandis Naser M. , Mekhamer Waffa , Aldayel Omar , Hefne Jameel A. A. , Alam Manawwer
Published: June 2019

The present work aims to investigate the ability of Saudi clay containing montmorillonite to remove Ag(I) and Cu(II) ions from aqueous solutions for waste water purification. The effect of pH, adsorbent mass, metal concentration, and contact time on the removal process has been investigated. The batch method was applied, using solution metal concentrations ranging from 40 to 2000 mg/L. Adsorption percentage and distribution coefficients (Kd) were determined as a function of metal concentration. pH 6 was found to be optimal for the adsorption. Adsorption reached equilibrium in 5 min for both Ag(I) and Cu(II) ions. The study on adsorption’s kinetic characteristics showed the adsorption process of these metal ions was of pseudo-second-order. Furthermore, the adsorption rate of Ag(I) was higher than that of Cu(II), and their adsorption appeared to follow the Langmuir isotherm. From the equilibrium studies, it was observed that the selectivity of Ag(I) was higher than that of Cu(II). The results showed that Saudi clay has the potential to be a suitable adsorbent for Ag(I) and Cu(II) removal from aqueous solutions compared with other adsorbents.
Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway
Authors: Meng Yan-Yan , Yuan Yu-Pei , Zhang Xin , Kong Chun-Yan , Song Peng , Ma Zhen-Guo , Tang Qi-Zhu
Published: June 2019

Oxidative stress and cardiomyocyte apoptosis play critical roles in the development of doxorubicin- (DOX-) induced cardiotoxicity. Our previous study found that geniposide (GE) could inhibit cardiac oxidative stress and apoptosis of cardiomyocytes but its role in DOX-induced heart injury remains unknown. Our study is aimed at investigating whether GE could protect against DOX-induced heart injury. The mice were subjected to a single intraperitoneal injection of DOX (15 mg/kg) to induce cardiomyopathy model. To explore the protective effects, GE was orally given for 10 days. The morphological examination and biochemical analysis were used to evaluate the effects of GE. H9C2 cells were used to verify the protective role of GE in vitro. GE treatment alleviated heart dysfunction and attenuated cardiac oxidative stress and cell loss induced by DOX in vivo and in vitro. GE could activate AMP-activated protein kinase α (AMPKα) in vivo and in vitro. Moreover, inhibition of AMPKα could abolish the protective effects of GE against DOX-induced oxidative stress and apoptosis. GE could protect against DOX-induced heart injury via activation of AMPKα. GE has therapeutic potential for the treatment of DOX cardiotoxicity.
Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD
Authors: Lv Wei-jie , Liu Cui , Li Yue-fei , Chen Wen-qian , Li Zeng-quan , Li Yue , Xiong Ying , Chao Li-min , Xu Xiao-long , Guo Shi-ning
Published: June 2019

Generally, inflammatory bowel disease (IBD) can be caused by psychology, genes, environment, and gut microbiota. Therefore, IBD therapy should be improved to utilize multiple strategies. Shen Ling Bai Zhu San (SLBZS) adheres to the aim of combating complex diseases from an integrative and holistic perspective, which is effective for IBD therapy. Herein, a systems pharmacology and microbiota approach was developed for these molecular mechanisms exemplified by SLBZS. First, by systematic absorption-distribution-metabolism-excretion (ADME) analysis, potential active compounds and their corresponding direct targets were retrieved. Then, the network relationships among the active compounds, targets, and disease were built to deduce the pharmacological actions of the drug. Finally, an “IBD pathway” consisting of several regulatory modules was proposed to dissect the therapeutic effects of SLBZS. In addition, the effects of SLBZS on gut microbiota were evaluated through analysis of the V3-V4 region and multivariate statistical methods. SLBZS significantly shifted the gut microbiota structure in a rat model. Taken together, we found that SLBZS has multidimensionality in the regulation of IBD-related physiological processes, which provides new sights into herbal medicine for the treatment of IBD.
Nocturnal Glycemic Control with New Insulin Glargine 300 U/mL
Authors: Yu Neng Chun
Published: June 2019

Insulin glargine 300 U/mL (Gla-300) is a new generation basal insulin product that has been demonstrated to have more stable pharmacokinetic and pharmacodynamic characteristics than insulin glargine 100 U/mL (Gla-100). To evaluate the real-world benefits of Gla-300 in reducing nocturnal fluctuations in blood glucose levels and nocturnal hypoglycemia, 10 Taiwanese patients using Gla-100 for insulin therapy were switched to Gla-300 and continuous glucose monitoring (CGM) was applied at nighttime to monitor changes to nocturnal glycemic variability parameters. Glycemic variability parameters measured to assess between- and within-night glycemic variability included mean 6-hour nocturnal (00:00–6:00 AM) glucose levels, standard deviation (SD), and coefficient of variance (CV) of mean nocturnal glucose levels and mean glucose excursion (MAGE). In this study, Gla-300 demonstrated comparable glycemic efficacy to Gla-100 and the potential to further reduce nocturnal hypoglycemia risk. Overall, nocturnal glycemic variability parameters measured during the Gla-300 treatment period were numerically smaller than those measured during the Gla-100 treatment phase although statistical significance was not reached. In terms of within-night glucose management, SD and CV values of mean nocturnal glucose levels were found to be statistically lower during the Gla-300 treatment phase than the Gla-100 treatment phase on nights individuals displayed normal blood glucose level readings at the beginning of the night. In summary, this study represents the first of its kind from Taiwan to evaluate the real-world clinical benefits of switching Taiwanese diabetes patients from Gla-100 to Gla-300 insulin therapy in reducing nighttime glucose variability by means of CGM.
Quality of Drinking Water from Springs in Palestine: West Bank as a Case Study
Authors: Daghara Azza , Al-Khatib Issam A. , Al-Jabari Maher
Published: June 2019

The shortage of fresh water creates acute challenges in the West Bank of Palestine. Springs provide a main water resource in the West Bank. Investigating springs’ water quality is essential step for promoting their public use. The aim of this research is to assess the microbiological and physiochemical quality parameters of drinking water from springs. The study methodology included sampling through field work and laboratory testing for water quality parameters using standard procedures. The study area covered all locations containing licensed springs by the Palestinian Water Authority in the West Bank of Palestine. The number of collected samples was 127 covering 300 springs. The chemical, physical, and biological parameters for each sample were measured. Then, the obtained characteristics were evaluated based on national and international quality standards (PSI and WHO). The investigated parameters included temperature, pH, EC, total hardness, concentrations of nitrate, sodium ions, total chlorine, residual chlorine, turbidity, and total and faecal coliforms. Most of investigated physical and chemical parameters were within the acceptable standard limits. However, the turbidity and chloride and nitrate concentrations exceeded standard limits. The findings indicate that only a minor fraction of the samples (2%) requires chlorination treatment, while most of the springs (97% of samples) are classified as possessing no risk.
Dialyzable Leukocyte Extract (Transferon™) Administration in Sepsis: Experience from a Single Referral Pediatric Intensive Care Unit
Authors: Castrejón Vázquez Maria Isabel , Reséndiz-Albor Aldo Arturo , Ynga-Durand Mario A. , Arciniega Martínez Ivonne Maciel , Orellana-Villazon Vanessa Ivonne , García López Carlos Alberto , Laue Noguera Maria Laura , Vargas Camaño Maria Eugenia
Published: June 2019

Immunomodulatory agents have been proposed as therapeutic candidates to improve outcomes in sepsis. Transferon™, a dialyzable leukocyte extract (DLE), has been supported in Mexico as an immunomodulatory adjuvant in anti-infectious therapy. Here we present a retrospective study describing the experience of a referral pediatric intensive care unit (PICU) with Transferon™ in sepsis. We studied clinical and laboratory data from 123 patients with sepsis (15 in the DLE group and 108 in the control group) that were admitted to PICU during the period between January 2010 and December 2016. Transferon™ DLE use was associated with lower C reactive protein (CRP), increase in total lymphocyte counts (TLC), and decrease in total neutrophil count (TNC) 72 hours after Transferon™ DLE administration. The control group did not present any significant difference in CRP values and had lower TLC after 72 hours of admission. There was no difference in PICU length of stay between control and Transferon™ DLE group. Transferon™ DLE administration was associated with a higher survival rate at the end of PICU stay. This study shows a possible immunomodulatory effect of Transferon™ on pediatric sepsis patients.
Effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs on Platelet Aggregation Rate and PI3K/Akt Pathway in the Rat Model of Coronary Heart Disease
Authors: Feng Hui , Wang Zhipeng , Wang Changsong , Zhu Xinyi , Liu Zhigang , Liu Hongmei , Guo Ming , Hou Qian , Chu Zhenrong
Published: June 2019

Aim. To investigate the effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs (FSAMB) on platelet aggregation rate of rats with coronary heart disease and discuss the mechanism of FSAMB affecting the platelet aggregation rate through PI3K/Akt pathway. We established the rat models with coronary heart disease (CHD) and prepared the platelet-rich plasma. The effect of different concentrations of FSAMB on platelet aggregation in SD rats induced by ADP was observed in vitro and in vivo. And Lactate Dehydrogenase (LDH), Creatine Kinase-MB Form (CK-MB), and Cardiac Troponin I (cTnI) are detected in the blood to know the level of damage to heart cells. The expansion of platelets in the immobilized fibrinogen in different concentrations of FSAMB was observed. Western blot was conducted to detect the phosphorylation level of protein kinase B (also known as Akt) and the expression level of phosphoinositide 3-kinase (PI3K). We found that FSAMB had a significant inhibitory effect on the ADP-induced platelet aggregation in vitro. Intragastric administration of FSAMB also inhibited platelet aggregation induced by ADP in rats. LDH, CK-MB, and cTnI levels in serum of rats in FSAMB (672 mg/kg) group were lower than those in the model control group after the intervention (P<0.01 or P<0.05). FSAMB inhibited the expansion of platelets on immobilized fibrinogen. Also, FSAMB inhibited ADP-induced platelet PI3K expression and Akt phosphorylation. The inhibition of Akt phosphorylation by FSAMB was more obvious after the inhibition of the expression of PI3K. This study demonstrated that FSAMB can reduce the degree of myocardial cell damage and inhibit ADP-induced platelet aggregation in SD rats, possibly by inhibiting platelet PI3K/Akt signaling pathway in vitro and in vivo.
Effect of Core Stability Training Monitored by Rehabilitative Ultrasound Image and Surface Electromyogram in Local Core Muscles of Healthy People
Authors: Zheng Yaochao , Ke Songjian , Lin Caina , Li Xiao , Liu Cuicui , Wu Yuanyuan , Xin Wenjun , Ma Chao , Wu Shaoling
Published: June 2019

Background. The purpose of this study is to investigate the influence of transverses abdominis and lumbar multifidus thickness activation and electromyogram signal characteristics after core stability training monitored by rehabilitative ultrasound imaging and surface electromyogram. Methods. 60 healthy volunteers were allocated randomly into two groups, one of which received monitoring training and the other participated identical training without monitoring. Ultrasound image and surface electromyogram signal were collected at 0, 4, and 8 weeks during training. The muscle thickness activation ratio value and integrated electromyogram value were then extracted. During the training, the monitoring group was monitored by real-time rehabilitative ultrasound imaging and surface electromyogram while the control group was not. Results. There are no differences in performance of local core muscles between both groups before training (p>0.05). Compared with the control group, the thickness contraction ratio value and integrated electromyogram value of core muscles in the monitoring group were higher after 8 weeks’ training (p<0.05). Conclusion. Together, the core stability training monitored by rehabilitative ultrasound imaging and surface electromyogram can markedly activate and enhance local core muscles in healthy people, providing a potential strategy to treat low back pain more effectively.
The Effectiveness of Acupoint Catgut Embedding Therapy for Abdominal Obesity: A Systematic Review and Meta-Analysis
Authors: Sheng Jili , Jin Xiaoqing , Zhu Jianfang , Chen Yidan , Liu Xu
Published: June 2019

Acupoint catgut embedding is a useful therapy for weight management and widely applied in China. This review aimed to systematically evaluate the effects of acupoint catgut embedding on abdominal obesity. We searched the PubMed, Cochrane-Library, Embase, OVID, MEDLINE, ISI (web of science), Wanfang, VIP, CBM, and CNKI for randomized controlled trials that used acupoint catgut embedding to treat abdominal obesity before April 2019 with the language restriction of Chinese and English. The combination subject terms of abdominal obesity (or central obesity) and acupoint catgut embedding (or catgut implantation, catgut embedding) were used. We found 15 studies involving 1584 individuals. When acupoint catgut embedding plus electroacupuncture is compared with electroacupuncture alone, significant reductions in improvement rate (RR = 1.03, 95% CI = 0.99~1.08), body weight (MD = 5.20, 95%CI = 1.16~9.25), body mass index (MD = 1.73, 95%CI = 0.70~2.76), waist circumference (MD = 2.91, 95%CI = 1.36~4.46), and hip circumference (MD = 1.06, 95%CI = -0.18~2.30) were found. Mean values of body weight by acupoint catgut embedding were 1.35 kg compared with electroacupuncture. Less adverse events were reported in all included articles. In summary, pooled outcomes of acupoint catgut embedding presented a tendency of equal effects to other kinds of acupuncture, whereas acupoint catgut embedding plus electroacupuncture is more effective for abdominal obesity. This study is registered with PROSPERO 2017 (CRD42017082357).
Multicenter, Open-Label, Phase II Study of Bendamustine and Rituximab Followed by 90-Yttrium (Y) Ibritumomab Tiuxetan for Untreated Follicular Lymphoma (Fol-BRITe)
Authors: Lansigan Frederick , Costa Cristiana A. , Zaki Bassem I. , Yen Stephanie P. , Winer Eric S. , Ryan Helen , Findley Darcie , Metzler Sara R. , Shaw Lynn , Toaso Bonnie , MacKenzie Todd A. , Chen Youdinghuan , Beaven Anne W.
Published: June 2019

Purpose:

Bendamustine and rituximab (BR) has been established as a superior frontline therapy over R-CHOP in the treatment of follicular lymphoma (FL). Yttrium-90 Ibritumomab tiuxetan (90YIT) is an effective consolidation strategy after chemotherapy induction. This prospective, single-arm, multicenter, phase II trial evaluated the response rate, progression-free survival (PFS), and tolerability of BR followed by consolidation with 90YIT in patients with untreated FL.

Patients and Methods:

The study included grade 1 to 3a FL patients aged ≥18 years, chemotherapy-naïve, and requiring treatment for stage II–IV disease. Study treatment included an initial rituximab treatment, followed by four cycles of BR. Patients were eligible for consolidation with 90YIT, 6 to 12 weeks after BR, if they obtained at least a partial response after induction had adequate count recovery and bone marrow infiltration < 25%.

Results:

Thirty-nine patients were treated. Eighty-two percent had an intermediate or high-risk Follicular Lymphoma International Prognostic Index score, and 6 of 39 (15%) were grade 3a. The response rate was 94.8%, and the complete response(CR)/CR unconfirmed (CRu) rate was 77% in the intention-to-treat analysis. The conversion rate from PR to CR/Cru after 90YIT was 81%. After median follow-up of 45 months, the PFS was 0.71 (95% confidence interval, 0.57–0.89).

Conclusions:

This report demonstrates that four cycles of BR followed by consolidation with 90YIT achieve high response rates that are durable. In addition, consolidation with 90YIT results in a high conversion rate of PR to CR/CRu. A short course of BR followed by 90YIT is a safe and effective regimen for frontline treatment of FL.
Pentecostalismo e questão racial no Brasil: desafios e possibilidades do ser negro na igreja evangélica
Authors: Reina Morgane Laure
Published: June 2019

Em um contexto de crescente intolerância religiosa no Brasil e dada a importância do pentecostalismo para a população negra, a relação entre fiéis negros e sua igreja torna-se um tema importante para a academia, embora seja pouco estudado e ainda mal delimitado. O objetivo deste artigo é estudar as possibilidades e os desafios para os negros de reivindicar sua etnicidade e historicidade dentro da comunidade eclesial: qual é o lugar dos fiéis negros – como indivíduos não branqueados – na igreja? Quais são as possibilidades de reconhecimento da sua identidade negra? Qual identidade deve ser reivindicada? Apesar de certa ausência desta discussão teórica em pesquisas sociológicas, este trabalho se baseia em uma revisão crítica da limitada literatura, aprofundada por uma observação participante e entrevistas. Apresenta um desafio heurístico e metodológico que busca uma melhor compreensão da questão da intolerância racial, cultural e religiosa na igreja evangélica. Nesta perspectiva, esta reflexão propõe uma abordagem interdisciplinar entre a sociologia da religião e a sociologia das relações e das desigualdades raciais, no fim de explorar que não há necessariamente um antagonismo entre a identidade negra e a identidade cristã.
The status of wild canids (Canidae, Carnivora) in Vietnam
Authors: Hoffmann Michael , Abramov Alexei , Duc Hoang Minh , Trai Le Trong , Long Barney , Nguyen An , Son Nguyen Truong , Rawson Ben , Timmins Robert , Bang Tran Van , Willcox Daniel
Published: June 2019

Four species of wild canids are documented as occurring in Vietnam: Dhole Cuon alpinus, Eurasian Golden Jackal Canis aureus, Red Fox Vulpes vulpes and Raccoon Dog Nyctereutes procyonoides.  Except for Dhole, all species are widely distributed globally and are listed as Least Concern on the IUCN Red List of Threatened Species.  Concerned by the paucity of recent records of these species from Vietnam, especially in the context of rapidly declining mammal populations in the country in general, we undertook a review of the status of these species in Vietnam.  All traceable and potentially verifiable canid records from 01 January 2002 until 31 December 2018 were collated and reviewed.  The Dhole, formerly the most widely distributed of all canid species in Vietnam, and Raccoon Dog, apparently formerly widely distributed in the northern part of the country, appear to have both declined; Dhole is now either extirpated, or close to extirpation, while Raccoon Dog is of uncertain status.  The Eurasian Golden Jackal does not seem to have been reliably observed in the wild since 2004, although it is possible the species may persist in some areas.  Red Fox has only ever been known from a handful of records, and the current status of this species is unknown. In summary, Vietnam cannot be considered to sustain healthy populations of any of its four native wild canid species. These declines seem largely attributable to hunting of both the canids themselves and, for Dhole, their prey base, exacerbated by habitat loss.
Remarks on the age of Dominican amber

Authors: ITURRALDE-VINENT MANUEL A. , MACPHEE ROSS D.E.
Published: June 2019

Amber from the Dominican Republic is famous for the high quality, frequency, and diversity of organic fossils found as inclusions in this mineral (Grimaldi, 1996; Poinar & Poinar, 1999). However, its geological age of origin remains a continuing source of controversy. Over the years a wide variety of age estimates have been made for occurrences of Dominican amber, ranging from Cretaceous (Brouwer & Brouwer, 1982) to Late Eocene (Lambert et al., 1985) to pre-Lower Miocene (Baroni-Urbani & Saunders, 1982). Some authors have also favored a spread of ages that covers much of the Cenozoic (e.g., 40 or 45 Ma to 15 Ma; Poinar & Poinar, 1999). Iturralde-Vinent & MacPhee (1996) attempted to resolve discrepancies in age assignments by taking a multi-pronged analytical approach which yielded a best-fit estimate of mid-Miocene age (20–15 Ma). This estimate has been widely accepted and additionally corroborated by new studies (Iturralde-Vinent, 2001; Ortega-Ariza et al., 2015). However, Braga et al. (2012) have challenged the assessment of Iturralde-Vinent & MacPhee (1996) by arguing for a Pliocene–early Pleistocene date for the amber-bearing Yanigua Formation. Here we address the sources of disagreement and suggest a solution.
LncRNA-ANRIL promotes gastric cancer progression by enhancing NF-kB signaling
Authors: Deng Wei , Zhang Yulong , Cai Jun , Zhang Jun , Liu Xiaoye , Yin Jie , Bai Zhigang , Yao Hongwei , Zhang Zhongtao
Published: June 2019

Metastasis is the most challenging issue for gastric cancer, and identification of the molecular mechanism and suitable targets for treatment is the major purpose of recent research. In this study, we found the long non-coding RNA ANRIL was critical for the progression of gastric cancer. Knockdown of ANRIL (also known as CDKN2B-AS) with shRNA increased apoptosis, inhibited tumor growth, and suppressed migration of cancer cells. TET2 (Tet Methylcytosine Dioxygenase 2), a methylcytosine dioxygenase suppressed ANRIL function and prevented cancer progression. Patients with higher TET2 expression survived better, while with higher ANRIL survived worse. Furthermore, expressions of TET2 and ANRIL were negatively correlated in the patient samples. The mechanistic study suggested that ANRIL promoted tumor progression mainly by enhancing NF-kB signaling.

Impact statement

Gastric cancer is one of the leading causes of cancer-related death. The lack of curative therapeutic options ascribes to the complex genetic background and heterogeneity of gastric cancer. Understanding the molecular details of the disease and identifying the therapeutic targets would offer additional treatment options. Long non-coding RNA ANRIL was involved in the progression of many cancers, including gastric cancer, but the mechanism was unknown. The current study indicated that ANRIL supported tumor cell survival by inhibiting apoptosis and promoted metastasis by enhancing NF-kB signaling. NF-kB signaling was critical in tumor progression, and this study proved another long non-coding RNA that could regulate NF-kB signaling. ANRIL would be a potential biomarker and therapeutic target for gastric cancer prognosis and treatment.
Incentives and the Supply of Effective Charter Schools
Authors: Singleton John D.
Published: June 2019

Charter school funding is typically set by formulas that provide the same amount for students regardless of advantage or need. I present evidence that this policy skews the distribution of students served by charters toward low-cost populations by influencing where charter schools open and whether they survive. To do this, I develop and estimate an equilibrium model of charter school supply and competition to evaluate the effects of funding policies that aim to correct these incentives. The results indicate that a cost-adjusted funding formula would increase the share of disadvantaged students in charter schools with little reduction in aggregate effectiveness. (JEL H75, I21, I22, I28)
УCТРAНEНИE ЛOЖНЫХ CУCТAВOВ ДЛИННЫХ ТРУБЧAТЫХ КOCТEЙ C ИCПOЛЬЗOВAНИEМ МAТEРИAЛOВ C ПAМЯТЬЮ ФOРМЫ
Authors: Radkevich Andrey Anatolevich , Sinyuk Vasily Pavlovich , Sinyuk Ilya Vasilevich
Published: June 2019

Цeль. Пoвышeниe эффeктивнocти хирургичecкoгo уcтрaнeния лoжных cуcтaвoв длинных трубчaтых кocтeй нa ocнoвe рaзрaбoтки нoвых мeдицинcких тeхнoлoгий c иcпoльзoвaниeм мaтeриaлoв c пaмятью фoрмы.Мaтeриaлы и мeтoды. 23 бoльным в вoзрacтe oт 1 гoдa дo 65 лeт c лoжными cуcтaвaми нижних кoнeчнocтeй выпoлняли рeзeкцию пaтoлoгичecких ткaнeй, пoмeщaли в зoну дeфeктa aутoocтeoгeнную ткaнь, мeлкoгрaнулирoвaнный пoриcтый никeлид титaнa, кoнcтрукции нa ocнoвe пoриcтoгo никeлидa титaнa, нacыщeнныe низкoдиффeрeнцирoвaнными клeтoчными элeмeнтaми мeзeнхимaльнoгo прoиcхoждeния, фикcирoвaли фрaгмeнты cкoбaми из никeлидa титaнa c пaмятью фoрмы. Для прeдoтврaщeния прoрacтaния в кocтную рaну coeдинитeльных ткaнeй co cтoрoны мышeчных cлoeв иcпoльзoвaли cвeрхэлacтичный тoнкoпрoфильный ceтчaтый никeлид титaнa, нaнeceнный пoвeрх cинтeзирoвaнных фрaгмeнтoв.Рeзультaты. Вo вceх cлучaях пoлучeн удoвлeтвoритeльный функциoнaльный рeзультaт.Зaключeниe. Cдeлaн вывoд o выcoкoй эффeктивнocти иcпoльзoвaния мaтeриaлoв c пaмятью фoрмы в кoмбинaции c ocтeoгeннoй ткaнью в хирургии лoжных cуcтaвoв длинных трубчaтых кocтeй.
ПОКАЗАТЕЛИ КЛЕТОЧНОГО ИММУНИТЕТА В КРОВИ У БОЛЬНЫХ ХРОНИЧЕСКИМ И ХРОНИЧЕСКИМ АТРОФИЧЕСКИМ ГАСТРИТОМ
Authors: Smirnova Olga Valentinovna , Sinyakov Alexander Alexandrovich
Published: June 2019

Helicobacter pylori является одной из распространенных причин возникновения хронических гастритов. В нашем исследовании мы изучили показатели клеточного иммунитета у больных хроническим гастритом и хроническим атрофическим гастритом на фоне Helicobacter pylori инфекции. У больных с атрофическим гастритом тела желудка регистрировались изменения иммунного статуса, проявляющиеся в развитии вторичного иммунодефицита.
КОМПЛЕКСНОЕ ПРИМЕНЕНИЕ МЕТОДОВ ИФА И ПЦР ДЛЯ ДИАГНОСТИКИ ЭПШТЕЙН-БАРР ВИРУСНОЙ ИНФЕКЦИИ
Authors: Smirnova Svetlana Sergeevna , Ivanova Natalia Aleksandrovna , Stepanova Tatyana Fedorovna
Published: June 2019

В статье рассматриваются результаты обследования пациентов ФБУН ТНИИКИП Роспотребнадзора на Эпштейн-Барр-вирусную инфекцию. Подтвердилось, что сочетание методов ИФА и ПЦР дает более полную информацию для постановки клинического диагноза, чем при изолированном их применении.
АНАЛИЗ СЕРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ СЫВОРОТОК КРОВИ НА КЛЕЩЕВОЙ ЭНЦЕФАЛИТ У НАСЕЛЕНИЯ ТЮМЕНСКОЙ ОБЛАСТИ ЗА 2016–2018 ГОДА
Authors: Zatsepina A. O. , Leontyeva S. A. , Bragina E. A.
Published: June 2019

Представлены результаты серологических исследований сывороток крови людей на содержание иммуноглобулина класса М к вирусу клещевого энцефалита у жителей г. Тюмени и юга Тюменской областиза 2016–2018 гг.
ДИНАМИКА ПОКАЗАТЕЛЕЙ, ХАРАКТЕРИЗУЮЩИХ ОРГАНИЗАЦИЮ ОБСЛЕДОВАНИЯ БЕРЕМЕННЫХ В ГОРОДАХ КРАСНОЯРСКОГО КРАЯ
Authors: Kurbanismailov Renat Badrudinovich , Narkevich Artem Nikolaevich
Published: June 2019

В статье представлена динамика показателей, характеризующих организацию обследования беременных в городах Красноярского края за период с 2012 по 2016 гг. Отмечено, что в городах Красноярского края за период с 2012 по 2016 гг. произошло снижение доли женщин, не наблюдавшихся в женской консультации, а также увеличение охвата беременных женщин 3-х кратным скрининговым УЗИ обследованием и выявляемости врожденных пороков развития.
THE DEFORMATION OF AZ31 MAGNESIUM ALLOY DURING WARM CONSTRAINED GROOVE PRESSING
Authors: Dang Hue Thi Hong , Pham Thuy Thi , Dao Ngung Minh , Pham Quang , Shchukin Valery Y.
Published: June 2019

A magnesium alloy AZ31 as plate of dimensions (60 x 60 x 3) mm has been constrained groove pressed (CGP) four deformation passes (16 pressings) at 250 oC by simulation and expremental. On the basis of the analysis of calculation results about the deformation distribution in the alloy AZ31 workpiece the mechanism for its microstructure evolution during the severe plastic deformation (SPD) process was partly clarified. On the other hand, deformation heterogeneity distribution developed in plate by applying CGP caused the evolution of a non-uniform microstructure. The TEM microstructure analysis results provided clear evidence that across the plate both the banded deformed microstructure where dislocation cell structure and/or partially or fully recovered polygonized subgrain microstructure are present. The recovering dynamic and local polygonization process contributes significantly to the formation of ultra-fine materials (UFG) microstructure.
THEORETICAL-EXPERIMENTAL POSSIBILLITIES OF MICROSTRUCTURE QUANTIFICATION OF DISPERSION STRENGTHENED MATERIALS
Authors: Besterci Michal , Sülleiová Katarína
Published: June 2019

The present paper is devoted to the possibilities to classify the spatial arrangement of the elements (features) of a stochastic process with geometrical objects. The fundamental quantities describing point processes were introduced. Experimental possibilities of structural objects determination, possibilities of evaluation of the size distribution of the secondary phases, testing of planar point structures (estimation of the process intensity, square method and characteristics of the second order) were estimated. Interparticle distances, namely mean interparticle distance, mean minimum distance, mean visibility and mean path of spherical contact were defined. Selected processes were described and demonstrated from simulated realizations on Al-Al4C3  dispersion strengthened material, prepared by a powder metallurgy method of reaction milling.  Interparticle distances of Al4C3 particles were evaluated. Polygonal methods and quadrant counts method were used for characterization of the particle arrangement.
INTERVENÇÕES URBANAS A PARTIR DE INVESTIMENTOS DO PROGRAMA DE ACELERAÇÃO DO CRESCIMENTO (PAC): A RETERRITORIALIZAÇÃO DOS MORADORES DO ENTORNO DA OBRA CONTORNO NORTE DE MARINGÁ-PR
Authors: Oliveira Adriano Aparecido de , Chagas Priscilla Borgonhoni , Borges William Antonio , Gonçalves Julia Silva
Published: June 2019

O presente artigo tem por objetivo compreender como ocorreu a reterritorialização, pelos moradores, de dois bairros fronteiriços a uma obra de grande magnitude - o Contorno Norte em Maringá (PR), realizada com recursos do Programa de Aceleração do Crescimento (PAC). Para tanto, o artigo apresenta conceitos relativos à produção do espaço urbano e território e caracteriza-se como qualitativo e descritivo. Foram realizadas entrevistas semiestruturadas com quatorze moradores e um representante do poder público municipal, além de pesquisa documental e bibliográfica. Esses dados foram analisados por meio da análise de conteúdo. Ao tratar da reterritorialização, foi possível concluir que os moradores sentem muita diferença no que diz respeito ao território em que viviam antes da construção da obra. Atualmente, eles relatam que se sentem excluídos do restante da população citadina e reconhecem diversos problemas socioespaciais, vistos por eles como um reflexo direto da construção da referida obra.
INOVAÇÃO EM MICRO E PEQUENAS EMPRESAS DE GOIÂNIA
Authors: Bontempo Paulo Cesar , Witotovicz Rodson Marden , Yoshitake Mariano
Published: June 2019

As micro e pequenas empresas podem utilizar recursos próprios para inovarem, podem utilizar recursos de bancos privados ou públicos. O objetivo deste estudo é verificar as principais características e dificuldades envolvendo a inovação em micro e pequenas empresas dos setores industrial, comercial e de serviços de Goiânia e para tanto, foi utilizada uma amostra de 228 micro e pequenas empresas do município. A metodologia da pesquisa é quantitativa, tendo sido utilizada a técnica de análise de correspondência. Foi possível verificar que, apesar das micro e pequenas empresas reconhecerem a importâncias das inovações, existem algumas dificuldades associadas à obtenção de recursos para inovar e que empresas dos três setores que utilizam uma combinação de recursos próprios e de bancos privados para promoverem suas inovações, têm mais sucesso em suas iniciativas. Por outro lado, é grande o número de empresas dos três setores que não dispões de recursos para inovar.
REVITALIZAÇÃO COMERCIAL: UMA ANÁLISE DO SISTEMA DE MARKETING CIRCUITO SILVA LOBO SOB A PERSPECTIVA DOS COMERCIANTES
Authors: Mota Débora Rocha , Leite Ramon Silva
Published: June 2019

Este estudo buscou analisar as transformações, percepções e perspectivas dos comerciantes envolvidos no desenvolvimento do Circuito Silva Lobo, um sistema de marketing que passou recentemente por um processo de revitalização comercial. A análise verificou a relação entre marketing e sociedade a partir do relacionamento de troca entre esses envolvidos, sob a ótica do macromarketing. Para isto, foi conduzida uma pesquisa exploratória, baseada em triangulação de métodos de coleta de dados, a qual contou com 13 entrevistas em profundidade com comerciantes do Circuito, além de análise documental e observação não participante. Verificou-se que projetos de revitalização comercial contribuem de forma significativa para o desenvolvimento econômico e social do seu entorno, gerando externalidades positivas. No entanto, tais iniciativas demandam engajamento dos participantes, além de planejamento que contemple medidas de curto, médio e longo prazo, pois qualquer desajuste pode implicar em uma reconfiguração das relações existentes, desestruturando ou inviabilizando o sistema de marketing.
PROPOSIÇÃO DE UM PROCESSO DE PLANEJAMENTO ESTRATÉGICO APOIADO NO BSC PARA O SERVIÇO PÚBLICO: O CASO DE UM SERVIÇO DE LICENCIAMENTO MUNICIPAL DE PEQUENAS REFORMAS
Authors: Fares Fábio Aranha , Bastos Sérgio Augusto Pereira , Fortunato Graziela Xavier
Published: June 2019

Governantes, servidores, usuários de serviços e a sociedade como um todo percebem que os governos municipais, no exercício do serviço de licenciamento de pequenas reformas em edificações, geram obstáculos ao desenvolvimento urbano por criar procedimentos ineficientes desprovidos de um direcionamento estratégico. Os gestores públicos estão muito focados nos aspectos urbanísticos e formais das edificações, mas usualmente desprezam uma visão de longo prazo. Com isso, a construção da legislação e a dinâmica operacional ocorrem de forma errática. É proposto, então, um processo de planejamento estratégico para unidade que presta o referido serviço público, com a utilização do Balanced Scorecard (BSC), a partir do planejamento estratégico do Município. Foram identificadas as perspectivas, os objetivos estratégicos, os indicadores, as metas e o mapa estratégico, utilizando a metodologia da pesquisa-ação. Além da contribuição teórica com a sugestão de uma perspectiva regulatória ao BSC, destacam-se as lições aprendidas com a aplicação do método escolhido.
OS (DES)AVANÇOS NOS NÍVEIS DE INDICADORES DE COMPETITIVIDADE DE DESTINOS TURÍSTICOS INDUTORES BRASILEIROS: O CASO DE SÃO RAIMUNDO NONATO
Authors: Zouain Deborah Moraes , Pereira Júnior Airton Nogueira , Souza Luiz Alexandre Valadão de , Duarte André Luís Faria
Published: June 2019

O turismo vem crescendo bastante em todo o mundo e sendo enquadrado na perspectiva econômica. Nesse contexto, o desempenho de seus destinos passou a ser avaliado com o mesmo parâmetro de outras atividades do mercado: a competitividade. No Brasil, para atender à meta do Plano Nacional de Turismo de estruturar 65 destinos turísticos, de modo a deixá-los em condições de competir internacionalmente, foi realizado um diagnóstico de seus níveis de competitividade. Para tanto, foi feita uma pesquisa documental, com abordagem qualitativa, visando a análise comparativa dos resultados do "Estudo dos 65 destinos" e a construção da agenda do Ministério do Turismo (MTur). A competitividade dos 65 destinos turísticos foi mensurada por meio de um indicador de competitividade composto de 13 pilares. No presente estudo, foi analisado o caso do Município de São Raimundo Nonato, que contribuiu para demonstrar possíveis falhas entre os resultados do Estudo e as ações do MTur.
TRANSPARÊNCIA PÚBLICA MUNICIPAL: UMA ANÁLISE DOS MUNICÍPIOS MINEIROS QUE DECRETAM CALAMIDADE FINANCEIRA
Authors: Sediyama Gislaine Aparecida Santana , Anjos Daniela Araújo dos , Felix Eliane Maria
Published: June 2019

Objetivou-se analisar a evidenciação das informações contábeis, financeiras e orçamentárias dos municípios mineiros que decretaram calamidade financeira e verificar se estas informações permitiam que os cidadãos inferissem sobre a materialidade da calamidade decretada. Para tanto, confrontou-se as informações divulgadas nos portais eletrônicos dos municípios e as exigências legais impostas pela LRF, Lei de Acesso a Informação e Lei da Transparência. Constatou-se que os municípios não cumpriram todas as exigências legais em termos de evidenciação nos sites oficiais das prefeituras, mas que o cidadão poderia acessá-las em sistemas de informações disponibilizados pelo Tribunal de Contas do Estado e o Sistema de Informações Contábeis e Fiscais do Setor Público Brasileiro. Assim, conclui-se que o cidadão poderia inferir sobre a calamidade pública financeira em nove dos dezessete municípios analisados, se conhecessem os demais sistemas de informações contábeis.
A new subspecies of Chrysochroa margotana Novak, 1992 (Coleoptera, Buprestidae) from Myanmar
Authors: Zubov A.S. , Titarenko A.Yu.
Published: June 2019

The paper provides the description of a new subspecies of Chrysochroa margotana Novak, 1992 from Burma and restoration of C. margotana Novak, 1992 as a valid specie name as a result of morphological analysis of close species from subgenus Chrooxantha, group mniszechi (Holynski, 2009).
The first record of Libellula depressa Linnaeus, 1758 (Odonata: Libellulidae) in Siberia, Russia
Authors: Kosterin O.E. , Gribkov A.V.
Published: June 2019

Libellula depressa (Linnaeus, 1758) was recorded from the NW foothills of Altai Mts. at the Inya River near the Chineta Village (51.34° N, 83.05° E) in Kranoshchekovo District of Altai Krai Province, Russia. This record was made for the first time in the territory of Russia, eastward of Urals and in 150 km NNE of the closest locality in East Kazakhstan in Ust’-Kamenogorsk (Oskemen).
Альго-пыльцевой мониторинг в Алтайском биосферном заповеднике (Республика Алтай, Россия)
Authors: Mitrofanova E.Yu. , Kuriatnikova N.A. , Malygina N.S. , Demberel О.
Published: June 2019

Представлены результаты исследований первичных биологических аэрозолей (пыльцевые спектры и водоросли) в атмосферных осадках, выпадавших на территории Алтайского биосферного заповедника (Республика Алтай, Россия) с июля по октябрь 2017 года. В проанализированных пробах было интерпретировано 28 таксонов пыльцевых зерен и водорослей. Анализ обратных траекторий движения воздушных масс, рассчитанных с помощью модели HYSPLIT, позволил определить основные регионы поступления пыльцевых зерен и водорослей на территорию Алтайского биосферного заповедника за указанный промежуток времени.
Managing the Measurement of Colonoscopy Quality
Authors: Dominitz Jason A. , Ko Cynthia W.
Published: June 2019

The adenoma detection rate (ADR) is our current best colonoscopy quality indicator, but it is not without limitations. In this issue of the Journal, novel ADR benchmarks are proposed based on historical local colonoscopy results. These minimally acceptable, standard of care, and aspirational benchmarks may encourage continuous quality improvement through the explicit determination of notably higher but proven achievable ADR targets, although validation in clinical practice is needed. Ultimately, we must transition from ADR measurement to the implementation of robust quality improvement processes that assure the best outcomes for our patients.
Processos de indeterminação em Acronon de H. J. Koellreutter
Authors: Bonafe Isabela Martins
Published: June 2019

O presente trabalho propõe a análise da peça Acronon, do maestro e compositor Hans Joachim Koellreutter, com base nas estéticas da indeterminação dos compositores John Cage e Pierre Boulez. Ambas as estéticas do século XX divergem a terminologia em significado, porém ainda sim é possível encontrá-las no processo de criação da peça para piano solo, Acronon. Buscar-se-á demonstrar como tais estéticas, por vezes divergentes, convergem na obra de Koellreutter, Acronon, por meio da análise e estudos a cerca do indeterminismo e serialismo de John Cage e Pierre Boulez.
Processos Interacionais na Educação Musical: reflexão sobre a aula de instrumento musical
Authors: Chagas Antonio
Published: June 2019

Este artigo busca apresentar reflexões sobre o processo de interação social durante uma aula de música. Para isso, será apresentado uma breve revisão de literatura tanto de conceitos sociológicos pertinentes ao tema quanto trabalhos na área da música que versam sobre esta temática. Em seguida, será apresentado trechos da análise de uma aula particular de violino, efetuados durante uma pesquisa de doutorado ( 2018) que buscou compreender as interações sociais construídas durante uma aula de instrumento musical para crianças. Como fundamentação teórica, utilizou-se os conceitos de Goffman (2010). Por meio das análises, foi possível compreender que os comportamentos dos indivíduos agem e moldam a interação estabelecida, em um processo constante de retroalimentação.
Narrativas de uma professora de um curso de Licenciatura em Música: entrelaçando memórias e práticas musicais
Authors: Torres Maria Cecilia de Araujo Rodrigues
Published: June 2019

Nos limites deste texto, trago um resumo de algumas reflexões sobra a minha aproximação e inserção como pesquisadora no campo dos estudos biográficos e das narrativas de si, entrelaçados com a educação musical e, desta forma, compartilho algumas narrativas autobiográficas como docente de um Curso de Graduação em Música/Licenciatura, no período entre 2008 e 2018. Rememoro questões que emergiram ao final da minha tese de doutorado no ano de 2003, na perspectiva de uma pesquisa no campo das autobiografias de si e memórias, e, desta maneira, busco entrelaçar narrativas diversas de discentes do curso em diferentes disciplinas e atividades tais como Projeto PIBID e Estágios Supervisionados em espaços não escolares no decorrer destes dez anos. Assumo assim o papel e a responsabilidade de narradora destas narrativas e memórias, em um diálogo com autores dos campos dos estudos autobiográficos/ narrativas e da educação musical, que realizam pesquisas neste campo teórico. Finalizo pontuando que este exercício de recontar e rememorar me constituem a cada dia como professora formadora/pesquisadora da área da Educação Musical.
Gib mir den Kopf des Pinkertons - Perspectivas teatrais em três processos em ópera
Authors: Veloso Mauricio Schwab
Published: June 2019

Este artigo se propõe a discutir as especificidades do trabalho de atuação dos cantores de ópera a partir de uma experiência de acompanhamento de três processos de ensaio na Alemanha em 2016. Partindo-se da compreensão do canto como uma ação vocal será analizada a possibilidade de se utilizar o processo de aprendizado e internalização da estrutura musical durante a preparação de uma nova partitura para estabelecer uma base de impulsos físicos que podem, graças à sua conexão com o universo ficcional dramatúrgico, servir como ponto de partida para o desenvolvimento do trabalho de atuação.
O diário de bordo e suas potencialidades pedagógicas
Authors: De Carvalho Larcher Pinto Lucas
Published: June 2019

Este artigo tem como objetivo reconhecer e explicitar algumas das possíveis potencialidades pedagógicas trazidas pela elaboração de diários de bordo em situações de criação e de ensino-aprendizagem no âmbito das Artes, em especial das Artes Cênicas. Para isso, foi realizada uma revisão bibliográfica sobre o diário de bordo, que apontou para a identificação deste como uma espécie de criação de natureza diversa a do processo artístico documentado, como um catalisador para as constantes (re)criações do sujeito – artista e autor -, fazendo-o refletir a partir de suas experiências, como um instrumento de avaliação, permitindo orientações e acompanhamento de percursos, e como uma fonte para pesquisas e/ou práticas pedagógicas. Aspectos estes que colaboram para o entendimento de que a criação de uma obra artística e/ou o ensino-aprendizagem em Artes se configuram como uma complexa trama que entrelaça a Arte e a Educação.
Alumni Komunikasi dan Penyiaran Islam (KPI) dan Peluang Kerja (Studi Alumni Pascasarjana UIN Ar-Raniry)
Authors: Usman A. Rani
Published: June 2019

Abstrak. Kompetensi adalah suatu hal yang dikaitkan dengan kemampuan, pengetahuan atau wawasan, dan sikap yang dijadikan suatu pedoman dalam melakukan tanggung jawab pekerjaan yang dikerjakan. Persaingan di bidang pendidikan tinggi menyebabkan bertambah dan berkurangnya yang mendaftar di perguruan tinggi. Keadaan ini memaksa kampus untuk mencari berbagai strategi baru yang menjadikan pendidikan tinggi Islam mampu bertahan dan berkembang dalam persaingan tingkat nasional bahkan tingkat dunia. Berdasarkan persoalan di atas, penulis ingin meneliti lebih lanjut tentang Kompetensi Alumni KPI dalam Mencari Peluang Kerja. Penelitian ini ingin mengkaji tentang bagaimana kompetensi dan kendala alumni KPI dalam mencari peluang kerja.Penelitian ini menggunakan pendekatan kualitatif dimana dalam penelitian ini lebih menekankan pada makna dan proses daripada hasil suatu aktifitas. Penelitian ini dilaksanakan di beberapa kantor pemerintahan di Kota Lhokseumawe. Hasil penelitian menunjukkan bahwa masyarakat memberikan perhatian penting terhadap lulusan atau alumni Fakultas Dakwah, khususnya alumni Komunikasi dan Penyiaran Islam (KPI) Universitas Islam Negeri (UIN) Ar-Raniry. Mereka mampu dan bisa tampil di forum-forum, menjadi penceramah, khatib, wartawan. Sebagian alumni KPI mendapatkan peluang kerja yang baik dari pemerintah, seperti ada yang menjadi Kepala Kantor Kemenag Lhokseumawe, Ketua MPU Lhokseumawe, Sekwan DPRK Lhokseumawe. Mereka juga bekerja di IAIN Lhokseumawe. Kendala alumni KPI dalam mencari kerja salah satunya adalah tidak adanya wadah perkumpulan alumni, sehingga sulit berbagi informasi, baik yang berhubungan dengan peluang kerja atau lainnya. Kendala lainnya adalah alumni KPI tidak mampu mengaplikasikan ilmu yang didapat saat menjadi mahasiswa, sehingga berefek dalam kehidupan sehari-hari