bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of fructose and mannose – regulatory peptides signaling pathway in porcine epithelial oviductal cells (OECs) primary cultured long-term in vitro
Authors: Nawrocki Mariusz J. , Budna Joanna , Celichowski Piotr , Khozmi Ronza , Bryja Artur , Kranc Wiesława , Borys Sylwia , Ciesiółka Sylwia , Knap Sandra , Jeseta Michal , Bukowska Dorota , Antosik Paweł , Brüssow Klaus P. , Bruska Małgorzata , Nowicki Michał , Zabel Maciej , Kempisty Bartosz
Published: October 2017

The morphological and biochemical modification of oviductal epithelial cells (OECs) belongs to the compound process responsible for proper oocytes transport and successful fertilization. However, the main mechanisms which regulated this process are still not entirely known. Moreover, the OECs metabolism, which may be identified as the “cellular activity” marker, is poorly recognized. In this study we investigated the fructose and mannose metabolic pathway in porcine OECs primary long-term cultured in vitro.

In our study, we employ a primary long term in vitro culture (IVC) and microarray approach (the Affymetrix microarray were used for analysis of transcriptomic profile of OECs) for expression levels analysis.

We found that from the whole analyzed transcriptome, 1537 genes were upregulated and 995 were down regulated after 7 days of culture, 1471 genes were upregulated and 1061 were downregulated after 15 days of culture and 1329 genes were upregulated and 1203 were downregulated after 30 days of culture. Moreover, the differential expression of SORD, FPGT, PFKFB4, TPI1, MPI, ALDOC, HK2 and PFKFB3 at 24 hours, 7 day, 15 day and 30 day, was also observed.

We suggested that fructose and mannose metabolism may be important molecular bio-marker of porcine OECs capability in in vitro model. The metabolic profile is significantly accompanied by cells proliferation in vitro. The transcriptomic profile of SORD, FPGT, PFKFB4, TPI1, MPI, ALDOC, HK2 and PFKFB3 expression may be identified as “fingerprint” of fructose and mannose metabolism in OECs as well as involved in cellular in vitro developmental capacity in pigs.
Investigating the degree of humorous enjoyment in reading Chinese language errors
Authors: Chen Guangyan
Published: October 2017

Second language learners often make errors when they use their target language for communication. People perceive some of these errors as humorous. Many factors influence these perceptions. The purpose of this study is to investigate how these factors affect people’s perceptions when they read CSL (Chinese as a second language) learners’ humorous errors. The factors mainly refer to error stimuli and readers’ backgrounds. The researcher collected 25 error stimuli from two popular and often-cited online articles. 57 participants responded to these errors and rated them in the following three categories: Very Funny, Somewhat Funny, and Not Funny. These participants included 51 Native Speakers (NSs) of Chinese and six Non-Native Speakers (NNSs). The NSs consisted of 28 females and 23 males. Out of the participants, 17 were Chinese teachers and 40 were non-teachers. The results indicate that teachers perceived these texts as less funny than non-teachers; No significant gender difference was found; NNSs seemed to perceive these error stimuli as less funny than NSs, however, readers should be cautious in interpreting this result because of the limited number of NNSs. In addition, this study compared the humorous texts that were perceived as the funniest and the ones perceived as the least funny. The results demonstrate that an error-evoked “Very Funny” joke text had two overlapping and opposing scripts. The more overlapping and opposing the two scripts within a joke text were, the more humorous enjoyment a reader experienced. These findings improve our understanding of the interrelationship of language and humor that has been neglected in CSL, Chinese linguistics, and humor literature.
Mathematical Modeling and Optimization of Syngas Production Process: A Novel Axial Flow Spherical Packed Bed Tri-Reformer
Authors: Karimipourfard Dornaz , Nemati Nasrin , Bayat Mehdi , Samimi Fereshteh , Rahimpour Mohammad Reza
Published: October 2017

A recently proposed approach for the production of syngas is Tri-reforming process. Significant preferences of tri-reforming over conventional reformers are high methane conversion in a single unit, in situ heat generation, carbon dioxide consumption and adjustable outlet H2/CO ratio. In this work, a one dimensional mathematical model was developed for a novel axial-flow spherical packed bed tri-reformer. The results of reforming model were compared with the process data obtained from conventional Lurgi-steam reformer (CSR). Effects of feed flow rate, inlet temperature and length per radius (L/R) of the reactor on outlet hydrogen yield, methane conversion and H2/CO ratio were also studied. To maximize the outlet hydrogen yield, operation conditions and L/R ratio of the reactor were optimized applying differential evolution (DE) method. Obtained results were then compared with non-optimized condition. High methane conversion (99.68 %), high hydrogen yield (1.896) and much lower pressure drop were the superiorities of the presented reactor to the previous configurations.
Functional limit theorem for a stopped random walk attaining a high level
Authors: Afanasyev Valeriy I.
Published: October 2017

For a stopped random walk with zero drift conditioned to attain a high level the theorem on the convergence in distribution to the Brownian high jump in the space D [0, +∞) is proved.
Bounded prefix concatenation operation and finite bases with respect to the superposition
Authors: Marchenkov Sergey S.
Published: October 2017

The paper is concerned with word functions over the alphabet {1,2}. Given arbitrary one-place functions f
1, …, f

l
, the class BPC[f
1, …, f

l
] is defined as the closure of the set of simplest word functions and the functions f
1, …, f

l
under the operations of superposition and bounded prefix concatenation. The class BPC[f
1, …, f

l
] is shown to have a finite basis with respect to the superposition.
Wastewater treatment in submerged aerated biofilter under condition of high ammonium concentration
Authors: Pawęska Katarzyna , Bawiec Aleksandra , Pulikowski Krzysztof
Published: October 2017

Treatment of wastewater produced in Service Areas (SA) located on expressways and highways is a worldwide problem because of increasing amount of roads and specific composition of those kinds of sewage. Insufficient removal of pollutants from wastewater discharged into surface water may cause serious environmental problems. In the present study efficiency of treatment of wastewater with high ammonium concentration in biological membrane system used on SA was investigated. Concentrations of ammonia nitrogen in wastewater flowing into bioreactor in none of the tested objects did not fall below 99.0 mg of N-NH4·dm−3. Because of high ammonium content in sewage and high pH reaching value about 9, it is almost impossible to create favorable conditions for microorganisms that run purification processes resulting in low efficiency of phosphorus and nitrogen removal (reduction of biogenic compounds did not exceed 15%). Treatment of wastewater consisting mainly of urine with commonly used biological membrane technology has to be widely tested to perform suitable quality of discharged wastewater, to provide safety of surface water environment.
Electrochemical, optical and morphological properties of poly (N-vinylcarbazole/TiO2) and (N-vinylcarbazole/aniline)/TiO2 copolymer prepared by electrochemical polymerization
Authors: Bouriche Ouahiba , Bouzerafa Brahim , Kouadri Hicham
Published: October 2017

Poly (N-vinylcarbazole) (PVK) and a new copolymer, PVK/polyaniline (PANI), have been successfully prepared by electrochemical polymerization of N-vinylcarbazole (NVK) and NVK/aniline from acetonitrile medium and LiClO4 supporting electrolyte. Composite thin films were studied by cyclic voltammetry (CV) in LiClO4/acetonitrile solutions on an indium tin oxide (ITO) electrode. The influences of concentration of titanium dioxide (TiO2) on the electrochemical properties of these composite materials were also investigated. The results of scanning electron microscopy (SEM) confirm the presence of TiO2 in the composite, which consequently modifies the morphology of the film significantly. Topographical analysis has shown that TiO2 nanoparticles (NPs) affect the morphology of thin films (roughness). The analysis of the voltammograms of PVK and of (PVK+PANI) before and after the addition of TiO2 at different concentrations shows a redox couple which was not observed in the absence of TiO2. The impedance spectroscopy study shows that the resistance of the PVK and (PVK+PANI) films decreases with increasing of TiO2 concentration, and this in turn contributes to a good conductivity of the film. The optical characterization of the composites has been carried out by UV-Vis absorption and photoluminescence (PL) spectroscopy and it was noted that the samples (PVK+10−2 TiO2) exhibited high transmittance (83%) in the visible region and a low gap value (2.69 eV) which confirms that this material can be used in a photovoltaic cell. This is explained by the introduction of the donor levels in the band gap of PVK by the TiO2, due to an effective doping.
Harmonicity and minimality of complex and quaternionic radial foliations
Authors: González-Dávila José Carmelo
Published: October 2017

We construct special classes of totally geodesic almost regular foliations, namely, complex radial foliations in Hermitian manifolds and quaternionic radial foliations in quaternionic Kähler manifolds, and we give criteria for their harmonicity and minimality.
Then examples of these foliations on complex and quaternionic space forms, which are harmonic and minimal, are presented.
An Efficient High-Frequency Method to Compute EM Scattering of a Target on Rough Surface
Authors: Yang Wei , Qi Cong-hui
Published: October 2017

The physical optics and shooting and bouncing rays method are combined to rapidly compute the electromagnetic (EM) scattering from electrically large three- dimensional targets on a dielectric rough surface. To avoid modeling the rough surface of infinite extent, image theory is first used to account for the EM interactions between the target and the infinite planar surface. Next, the dielectric rough surface is accounted for by multiplying the Fresnel reflection coefficient with a roughness coefficient. In this way, only the target needs to be modeled. Thus, the proposed method can reduce significantly the computational costs and achieve a reasonable accuracy for the composite scattering problem, such as a ship-sea model.
Sero Survey of Foot and Mouth Disease Virus Infection in Cattle Crossing Some Major Border States in Northwestern Nigeria
Authors: Babangida D. , Ibrahim A. A. , Oladayo F. O. , Magaji A. A. , Alkali B. R. , Jibril A. H.
Published: October 2017

Foot and mouth disease (FMD) poses a major constraint to international trade in animals and animal products in sub-Saharan Africa. A retrospective and serological survey was conducted in two major Border States of Sokoto and Kebbi in north-western Nigeria. This study was aimed at determining the sero-prevalence of FMD virus (FMDV) antibodies in cattle at international animal control posts and to examine cattle population movement across the border area for a period of one year (January to December 2014) from the available records. Eight hundred and eighty (880) sera samples were collected and screened for the presence of antibodies to FMDV using the competitive enzyme linked immunosorbent assay (ELISA) technique. The data were subjected to chi-square and relative risk to check for independence and association. An overall seropositive rate was found to be 55.2 % (486/880). A 79.9 % (359/450) sero-positive rate was obtained from the Kamba border, while 29.5 % (127/430) was found at the Illela border. Kamba showed a statistically significant (P < 0.05) higher sero-prevalence when compared with cattle that are crossing the Illela border (Relative Risk 2.70; 95 % Confidence Interval 2.317—3.149). Retrospective data from the control posts revealed that an average number of 2019 and 2747 of cattle, respectively, crossed the Kamba and Illela international borders monthly. The highest influx of animals from the Niger Republic through the Illela international border was encountered between the month of March and April 2014. The magnitude of the presence of FMDV Non-structural protein (NSP) antibodies in the study areas is an indication of the infection and the presence of the virus in the study areas and the neighbouring countries.
Effects of Electrolyte Concentration and Ultrasound Pretreatment on Ohmic-Assisted Hydrodistillation of Essential Oils from Mentha piperita L.
Authors: Gavahian Mohsen , Farhoosh Reza , Javidnia Katayoun , Shahidi Fakhri , Golmakani Mohammad-Taghi , Farahnaky Asgar
Published: October 2017

In this study, the effects of salt concentration (1, 3 and 6% w/v) and ultrasound pretreatment (50 W for 5, 10 and 15 minutes) on extraction parameters and extracted essential oil from peppermint by ohmic-assisted hydrodistillation (OAHD), a recently innovated extraction technique, have been studied. The results showed that salt concentration significantly affected the extraction parameters of OAHD, while ultrasound pretreatment had negligible effect. Sudden eruption of essential oil glands was observed in scanning electron micrographs of all OAHDs mint leaves. GC-MS analysis did not indicate any noticeable change in the compounds of all the extracted essential oils. The results of this study showed that increase of electrolyte concentration could speed up OAHD process without any adverse effect on essential oil quality, while ultrasound pretreatment neither reduced process time nor increased extraction yield of OAHD.
Catalytic processes in the chemistry of lactic acid and PLLA: enzymatic stereoselective alcoholysis of rac-lactide
Authors: Shuklov Ivan A. , Shuklov Alexey D. , Dubrovina Natalia V. , Kühlein Klaus , Börner Armin
Published: October 2017

The preparation of the enantiomerically pure (R,R)-lactide (>99%ee) on the gram scale by alcoholysis of rac-lactide in the presence of Amano lipase PS is described. The synthesis of enantiopure lactide by this method is advantageous over traditional preparation via thermal tin-catalysed cyclisation of corresponding oligolactic acids, since the reaction temperature are much lower. That results that no meso-lactide is formed. The alcoholysis of rac-lactide with n-BuOH was studied in the presence of various enzymes in different solvent systems. The kinetic study of the alcoholysis of rac-lactide in the presence of CALB was performed.
Application of an Autonomous/Unmanned Survey Vessel (ASV/USV) in Bathymetric Measurements
Authors: Specht Cezary , Świtalski Emilian , Specht Mariusz
Published: October 2017

The accuracy of bathymetric maps, especially in the coastal zone, is very important from the point of view of safety of navigation and transport. Due to the continuous change in shape of the seabed, these maps are fast becoming outdated for precise navigation. Therefore, it is necessary to perform periodical bathymetric measurements to keep them updated on a current basis. At present, none of the institutions in Poland (maritime offices, Hydrographic Office of the Polish Navy) which are responsible for implementation of this type of measurements has at their disposal a hydrographic vessel capable of carrying out measurements for shallow waters (at depths below 1 m). This results in emergence of large areas for which no measurement data have been obtained and, consequently, the maps in the coastal zones are rather unreliable.

The article presents the concept of bathymetric measurements for shallow waters with the use of an autonomous, unmanned survey vessel (ASV/USV). For this purpose, the authors modernized a typical ASV/USV unit with standard radio remote control system to the fully autonomous mode. As part of the modernization, the route planning software was created. The developed software works based on, alternatively, GNSS measurements of the coastline, or satellite images. The system was supplemented by an own autopilot (adapted for flying drones). Moreover, the method of controlling electric motors was changed thanks to the use of own electronic circuit.

The modernized ASV/USV measuring system was verified by performing bathymetric measurements of the retention reservoir in Gdansk, Poland. Then, the obtained measurement data were used to create a digital bottom model and a bathymetric map of the reservoir.
Problems of the Starting and Operating of Hydraulic Components and Systems in Low Ambient Temperature (Part IV)
Authors: Jasiński Ryszard
Published: October 2017

Designers of hydraulically driven machines and devices are obliged to ensure during design process their high service life with taking into account their operational conditions. Some of the machines may be started in low ambient temperature and even in thermal shock conditions (due to delivering hot working medium to cold components). In order to put such devices into operation appropriate investigations, including experimental ones - usually very expensive and time-consuming, are carried out. For this reason numerical calculations can be used to determine serviceability of a hydraulic component or system operating in thermal shock conditions. Application of numerical calculation methods is much less expensive in comparison to experimental ones. This paper presents a numerical calculation method which makes it possible to solve issues of heat exchange in elements of investigated hydraulic components by using finite elements method. For performing the simulations the following data are necessary: ambient temperature, oil temperature, heat transfer coefficient between oil and surfaces of elements, as well as areas of surfaces being in contact with oil. By means of computer simulation method values of clearance between cooperating elements as well as ranges of parameters of correct and incorrect operation of hydraulic components have been determined. In this paper results of computer simulation of some experimentally tested hydraulic components such as axial piston pump and proportional spool valve, are presented. The computer simulation results were compared with the experimental ones and high conformity was obtained.
Modern Modeling of Water Hammer
Authors: Urbanowicz Kamil
Published: October 2017

Hydraulic equipment on board ships is common. It assists in the work of: steering gear, pitch propellers, watertight doors, cargo hatch covers, cargo and mooring winches, deck cranes, stern ramps etc. The damage caused by transient flows (which include among others water hammer) are often impossible to repair at sea. Hence, it is very important to estimate the correct pressure runs and associated side effects during their design. The presented study compares the results of research on the impact of a simplified way of modeling the hydraulic resistance and simplified effective weighting functions build of two and three-terms on the estimated results of the pressure changes. As it turns out, simple effective two-terms weighting functions are able to accurately model the analyzed transients. The implementation of the presented method will soon allow current automatic protection of hydraulic systems of the adverse effects associated with frequent elevated and reduced pressures.
Urban Geomorphological Heritage. An Overview
Authors: Reynard Emmanuel , Pica Alessia , Coratza Paola
Published: October 2017

Urbanization is a global phenomenon and currently more than half of the world’s population lives in urban areas. Studies on geomorphological heritage and the development of specific methods of investigation (assessment, inventories, cartography) are, however, relatively rare and limited. This paper first describes the relationships between urbanization and geomorphology. Secondly, it presents an overview of the main works on the urban geomorphological heritage. Then, the main methods of investigation are presented. Finally, we discuss the challenging issues concerning the protection and the promotion of the urban geomorphological heritage.
From Urban Geodiversity to Geoheritage: The Case of Ljubljana (Slovenia)
Authors: Tičar Jure , Komac Blaž , Zorn Matija , Ferk Mateja , Hrvatin Mauro , Ciglič Rok
Published: October 2017

The city of Ljubljana lies at the intersection of various geomorphological regions that have strongly influenced its spatial organization. Prehistoric settlements were built on marshland, a Roman town was built on the first river terrace of the Ljubljanica River, and in the Middle Ages a town was built in a strategic position between the Ljubljanica River and Castle Hill. The modern city absorbed all usable space between the nearby hills. This paper reviews some relief features in Ljubljana, their influence on the city’s spatial development, and urban geoheritage. The results indicate new possibilities for urban geoheritage tourism in the Slovenian capital and its surroundings.
Potential Values of Urban Geotourism Development in a Small Polish Town (Pruszków, Central Mazovia, Poland)
Authors: Górska-Zabielska Maria , Zabielski Ryszard
Published: October 2017

The paper presents abiotic resources which are located in a small town in central Poland. They remain unknown to authorities and inhabitants. For the first time they are illustrated in a scientific paper. The objects of local geological heritage point to geodiversity of this district town in the south-western Mazovia. When the geodiversity is interpreted in a simple, an understandable way, it may become attractive for tourists. We show how abiotic resources located within an urban area can be used to support urban geotourism development. The scientific, educational and aesthetic values of these resources may create the town image in accordance with the principles of environmental protection.
Geomorphological and Anthropic Control of the Development of Some Adriatic Historical Towns (Italy) Since the Roman Age
Authors: Dall’Aglio Pier Luigi , de Donatis Mauro , Franceschelli Carlotta , Guerra Cristiano , Guerra Veronica , Nesci Olivia , Piacentini Daniela , Savelli Daniele
Published: October 2017

The geomorphological analysis of historically urbanized areas is the best scientific way to understand how the extant geomorphological factors conditioned urbanization. It also provides a baseline to enable comparisons to be made with the modern environment. This paper considers four urbanized historical sites on the Adriatic coast (Italy) that owe their urban development to particular geomorphological and environmental conditions that were modified over the centuries from the Roman age to the present day. The focus here is on the evolution of the shoreline and associated geomorphic variables (streambeds and river mouths migration). These factors are fundamental for determining the development of a city, both as basic boundary elements – therefore including defence and protection – and also for the development of harbours.
Typology of Household Strategies of Action in Four Countries of Southeastern Europe in a Period of Economic Crisis
Authors: Cvetičanin Predrag , Lavrič Miran
Published: October 2017

In this paper, we explore whether the myriad production and consumption household practices in four societies of Southeastern Europe (Bosnia-Herzegovina, Croatia, Serbia and Slovenia) can empirically be reduced to a relatively small number of coherent and socially meaningful combinations, which we have labelled household strategies of action. Approaching the same data from two different angles, namely, using Multiple Correspondence Analysis (MCA) and Two-Step Cluster Analysis (TCA), we have identified five general household strategies and eleven more detailed and specific sub-strategies. More importantly, by projecting these strategies and sub-strategies onto the social space, we have shown that these household practices are linked to the class position of households. On a more general level, it is indicated that the study of household strategies can be viewed as a way of rendering relatively static structural approaches, in this case the Bourdieusian approach to social space, more dynamic.
Coping Strategies of Economically (Partially) Inactive Households: The Case of Croatia
Authors: Bagić Dragan , Dobrotić Ivana , Lažnjak Jasminka , Rodik Petra , Vučkovićjuroš Tanja
Published: October 2017

How do households with inactive or unemployed members face growing risks and uncertainty? The present study tackles this problem with a case study on Croatia, a country at the bottom of the European Union’s (EU) scale of economic activity rate. The low level of activity that has characterized Croatia for more than twenty years has been accompanied by a continuously high unemployment rate, which has further increased since 2009. In this context, households with (long-term) inactive or unemployed members have had to develop alternative coping strategies. In order to identify and examine these strategies, in 2014 we conducted a mixed-method study, including a quantitative survey of 453 households and 37 semi-structured interviews. We identified six household strategies, more or less ‘successful’ in terms of the household’s material position. In this essay we further examine these strategies’ characteristics and implications, with a focus on the profiles of households employing specific strategies.
Scholars (Not) Investigating Srebrenica. Academic Feuds and Other Shortcomings
Authors: Duijzings Ger
Published: October 2017

Fifteen years after the publication of the Srebrenica report by the Netherlands Institute for War Documentation (NIOD), the Srebrenica genocide has not become subject of more scholarly and historical research. On the contrary, academics prefer to keep their hands off the topic, confining themselves to ‘theoretical’, ‘reflexive’, or ‘moralistic’ reflections on the work done by the NIOD team. Symptomatic of the current state of inertia and diminishing professional standards is the recent book by the Dutch historian and psychologist Eelco Runia in which he attacks the NIOD report from a psychoanalytic standpoint.
Wattwaage mit Hebelübersetzung auf Basis eines kommerziellen EMK-Wägesystems
Authors: Hilbrunner Falko , Rahneberg Ilko , Fröhlich Thomas
Published: October 2017

Bei Waagen nach dem Prinzip der elektromagnetischen Kraftkompensation
wird die auf eine Waagschale wirkende Gewichtskraft eines Wägegutes
durch eine elektromagnetische Gegenkraft kompensiert. Nach dem Stand
der Technik wird der Zusammenhang zwischen dem, die Gegenkraft
erzeugendem Aktorstrom durch eine Spule und der Gewichtskraft des
Wägegutes durch Kalibrierung mit Massenormalen hergestellt. Mit der
für 2018 zu erwartenden Neudefinition der SI-Einheit der Masse durch
Festlegung eines Wertes der Planck-Konstanten wird ein unmittelbarer
Zusammenhang zwischen den mechanischen und elektrischen Größen
geschaffen, so dass das aus Fundamentalexperimenten bekannte
Wattwaagenprinzip zur Kalibrierung von Massen eingesetzt werden kann.
Im vorliegenden Artikel wird eine darauf aufbauende Methode zur
Bestimmung des Kraftfaktors Bl einer kommerziellen EMK-Wägzelle
vorgestellt. Dies geschieht durch die simultane Messung der Spannung
über der im Magnetfeld bewegten Spule und deren Geschwindigkeit.
Dabei wird im vorgestellten Verfahren die Spule gleichzeitig zur
Erzeugung der Bewegung mit einem harmonischen Wechselsignal bestromt.
Die Frequenz der harmonischen Bewegung hat hierbei maßgeblichen
Einfluss auf die Unsicherheit des resultierenden Kraftfaktors. Eine
Trennung der Spannungsanteile über der Spule erfolgt durch simultane
Messung von Strom und Spannung an der Spule und Auswertung unter
Berücksichtigung der vorliegenden Amplituden und Phasenlagen. Die
Spule ist hierbei, wie bei kommerziellen EMK-Wägezellen üblich, über
ein mechanisches Hebelwerk angekoppelt. Durch diese Hebelübersetzung
ist es möglich, mit einem kompakten elektrodynamischen Aktuator
(Spule–Permanentmagnetsystem), einen großen wirksamen Kraftfaktor zu
realisieren.

Im Ergebnis können mit dem System Kräfte in beliebiger Raumrichtung
gemessen bzw. erzeugt werden, wobei die Massebestimmung einen
Spezialfall darstellt, für den zusätzlich die lokale
Fallbeschleunigung bekannt sein muss. Unter Nutzung der gleichen
Methodik kann durch Vertauschung von Eingangs- und Ausgangsgrößen des
Formalismus, die EMK-Wägezelle auch als Positionssensor eingesetzt
werden. Hierbei erfolgt unter Zuhilfenahme eines Referenzgewichtes
(Justiergewichtes) und der Ausgangsspannung des Positionssensors des
Wägesystems eine Kalibrierung der Auslenkung des Koppelstücks. Für
beide Verfahren werden im Gegensatz zu Fundamentalexperimenten
industriell relevante Messunsicherheiten im ppm-Bereich
angestrebt. Es werden Messungen für beide Messmodi auf Basis
kommerziell verfügbarer EMK-Wägezellen und elektrischer Messtechnik
vorgestellt und diskutiert.
Bestimmung der temperaturabhängigen Oberflächenspannung des Eisen-Nickel-Systems mittels elektromagnetischer Levitation
Authors: Leitner Thomas , Klemmer Olivia , Pottlacher Gernot
Published: October 2017

Für das Eisen-Nickel-Legierungssystem wird die Oberflächenspannung in Abhängigkeit der Temperatur in der flüssigen Phase
untersucht. Hierfür kommt an der Technischen Universität Graz (TU Graz) die Methode des oszillierenden Tropfens (engl.:
oscillating drop, OD) in Kombination mit einer elektromagnetischen Levitations-Apparatur zum Einsatz.

Die elektromagnetische Levitation (EML) stellt eine elegante experimentelle Methode dar, um die Oberflächenspannung und
Dichte von Reinmetallen und Legierungen zu untersuchen, da sie den Anforderungen einer kontaktfreien, behältnislosen
Messmethode genügt. Mittels Hochgeschwindigkeitskameras und Software zur Kantenerkennung wird das Volumen sowie ein
Frequenzspektrum der Oberflächenoszillationen der Probe ermittelt. Aus den Oszillationsfrequenzen kann schließlich die
Oberflächenspannung berechnet werden.

Essentiell für dieses Experiment ist die Temperaturmessung, die ebenfalls kontaktlos mittels Einwellenlängen-Pyrometer
durchgeführt wird, wobei eine Kalibration des Emissionsgrades bei einer Referenztemperatur, z. B. am Schmelz- oder
Erstarrungsplateau erfolgt. Zusätzlich wird seit kurzem ein Zweiwellenlängen-Pyrometer im Quotientenmodus genutzt, um die
Resultate der Temperaturmessung zu überprüfen.

Diese Arbeit enthält aktuelle experimentelle Messergebnisse mit einer Unsicherheitsangabe nach GUM. Die ermittelten
Messdaten werden, sofern verfügbar, mit bereits existierenden experimentellen Daten aus der Literatur verglichen.
Experimental and Analytical Modal Analysis of Cantilever Beam for Vibration Based Damage Identification Using Artificial Neural Network
Authors: Rao P. S. , Ramakrishna V. , Mahendra N. V. D.
Published: October 2017

This paper presented procedures of experimental and analytical modal analysis of cantilever beam used for vibration-based damage identification using an artificial neural network (ANN). It is a part of structural health monitoring. The process of implementing a damage detection strategy for aerospace, civil, and mechanical engineering structures is referred to as SHM. Experimental modal analysis involves acquisition of point-to-point frequency response functions at a set of points for a dynamic model. Analytical modal analysis uses differential equations of motion of a structure using a theoretical and finite element modeling technique. In experimental modal analysis, the transient excitation method of modal testing is conducted using an impact hammer test. We considered two cantilever beams of different materials, i.e., aluminum and stainless steel. Different crack lengths were introduced on the beams by cutting the slot. Slot lengths were 2, 4, 6, 8, and 10 mm, with cracks designated as damage level 1, 2, 3, 4, and 5, respectively. The undamaged cantilever structure was treated as damage level 0. The analytical modal analysis was performed using ANSYS 15. The geometric models for analytical modal analysis were developed using CATIA V5R20. A cantilever beam of longitudinal crack at different crack lengths and materials was considered for analysis. The experimental modal analysis was validated with analytical modal analysis. It was observed that there was no change in the first mode; for higher modes, there is a decrease in natural frequencies with the increase in crack length. Frequency response functions were obtained from the experimental modal analysis. These can be used for damage identification using ANN.
Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron–Glia Cell-Fate Switch in the Developing Hippocampus
Authors: Muralidharan Bhavana , Keruzore Marc , Pradhan Saurabh J. , Roy Basabdatta , Shetty Ashwin S. , Kinare Veena , D'Souza Leora , Maheshwari Upasana , Karmodiya Krishanpal , Suresh Agasthya , Galande Sanjeev , Bellefroid Eric J. , Tole Shubha
Published: October 2017

Regulation of the neuron–glia cell-fate switch is a critical step in the development of the CNS. Previously, we demonstrated that Lhx2 is a necessary and sufficient regulator of this process in the mouse hippocampal primordium, such that Lhx2 overexpression promotes neurogenesis and suppresses gliogenesis, whereas loss of Lhx2 has the opposite effect. We tested a series of transcription factors for their ability to mimic Lhx2 overexpression and suppress baseline gliogenesis, and also to compensate for loss of Lhx2 and suppress the resulting enhanced level of gliogenesis in the hippocampus. Here, we demonstrate a novel function of Dmrt5/Dmrta2 as a neurogenic factor in the developing hippocampus. We show that Dmrt5, as well as known neurogenic factors Neurog2 and Pax6, can each not only mimicLhx2overexpression, but also can compensate for loss of Lhx2 to different extents. We further uncover a reciprocal regulatory relationship between Dmrt5 and Lhx2, such that each can compensate for loss of the other. Dmrt5 and Lhx2 also have opposing regulatory control onPax6andNeurog2, indicating a complex bidirectionally regulated network that controls the neuron–glia cell-fate switch.

SIGNIFICANCE STATEMENTWe identify Dmrt5 as a novel regulator of the neuron–glia cell-fate switch in the developing hippocampus. We demonstrate Dmrt5 to be neurogenic, and reciprocally regulated by Lhx2: loss of either factor promotes gliogenesis; overexpression of either factor suppresses gliogenesis and promotes neurogenesis; each can substitute for loss of the other. Furthermore, each factor has opposing effects on established neurogenic genesNeurog2andPax6. Dmrt5 is known to suppress their expression, and we show that Lhx2 is required to maintain it. Our study reveals a complex regulatory network with bidirectional control of a fundamental feature of CNS development, the control of the production of neurons versus astroglia in the developing hippocampus.

Finally, we confirm that Lhx2 binds a highly conserved putative enhancer ofDmrt5, suggesting an evolutionarily conserved regulatory relationship between these factors. Our findings uncover a complex network that involves Lhx2, Dmrt5, Neurog2, and Pax6, and that ensures the appropriate amount and timing of neurogenesis and gliogenesis in the developing hippocampus.
Persistent hyperthyroidism and de novo Graves’ ophthalmopathy after total thyroidectomy
Authors: Tay Wei Lin , Loh Wann Jia , Lee Lianne Ai Ling , Chng Chiaw Ling
Published: October 2017

We report a patient with Graves’ disease who remained persistently hyperthyroid after a total thyroidectomy and also developed de novo Graves’ ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion.

Learning points:

It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy.

TSH receptor antibody may persist after total thyroidectomy and may potentially contribute to the development of de novo Graves’ ophthalmopathy.
Dendritic Cytoskeletal Architecture Is Modulated by Combinatorial Transcriptional Regulation in Drosophila melanogaster
Authors: Das Ravi , Bhattacharjee Shatabdi , Patel Atit A , Harris Jenna M , Bhattacharya Surajit , Letcher Jamin M , Clark Sarah G , Nanda Sumit , Iyer Eswar Prasad R , Ascoli Giorgio A , Cox Daniel N
Published: October 2017

Transcription factors (TFs) have emerged as essential cell autonomous mediators of subtype specific dendritogenesis; however, the downstream effectors of these TFs remain largely unknown, as are the cellular events that TFs control to direct morphological change. As dendritic morphology is largely dictated by the organization of the actin and microtubule (MT) cytoskeletons, elucidating TF-mediated cytoskeletal regulatory programs is key to understanding molecular control of diverse dendritic morphologies. Previous studies in Drosophila melanogaster have demonstrated that the conserved TFs Cut and Knot exert combinatorial control over aspects of dendritic cytoskeleton development, promoting actin and MT-based arbor morphology, respectively. To investigate transcriptional targets of Cut and/or Knot regulation, we conducted systematic neurogenomic studies, coupled with in vivo genetic screens utilizing multi-fluor cytoskeletal and membrane marker reporters. These analyses identified a host of putative Cut and/or Knot effector molecules, and a subset of these putative TF targets converge on modulating dendritic cytoskeletal architecture, which are grouped into three major phenotypic categories, based upon neuromorphometric analyses: complexity enhancer, complexity shifter, and complexity suppressor. Complexity enhancer genes normally function to promote higher order dendritic growth and branching with variable effects on MT stabilization and F-actin organization, whereas complexity shifter and complexity suppressor genes normally function in regulating proximal-distal branching distribution or in restricting higher order branching complexity, respectively, with spatially restricted impacts on the dendritic cytoskeleton. Collectively, we implicate novel genes and cellular programs by which TFs distinctly and combinatorially govern dendritogenesis via cytoskeletal modulation.
Toward a qualitative understanding of binge-watching behaviors: A focus group approach
Authors: Flayelle Maèva , Maurage Pierre , Billieux Joël
Published: October 2017

Background and aims

Binge-watching (i.e., seeing multiple episodes of the same TV series in a row) now constitutes a widespread phenomenon. However, little is known about the psychological factors underlying this behavior, as reflected by the paucity of available studies, most merely focusing on its potential harmfulness by applying the classic criteria used for other addictive disorders without exploring the uniqueness of binge-watching. This study thus aimed to take the opposite approach as a first step toward a genuine understanding of binge-watching behaviors through a qualitative analysis of the phenomenological characteristics of TV series watching.

Methods

A focus group of regular TV series viewers (N = 7) was established to explore a wide range of aspects related to TV series watching (e.g., motives, viewing practices, and related behaviors).

Results

A content analysis identified binge-watching features across three dimensions: TV series watching motivations, TV series watching engagement, and structural characteristics of TV shows. Most participants acknowledged that TV series watching can become addictive, but they all agreed having trouble recognizing themselves as truly being an “addict.” Although obvious connections could be established with substance addiction criteria and symptoms, such parallelism appeared to be insufficient, as several distinctive facets emerged (e.g., positive view, transient overinvolvement, context dependency, and low everyday life impact).

Discussion and conclusion

The research should go beyond the classic biomedical and psychological models of addictive behaviors to account for binge-watching in order to explore its specificities and generate the first steps toward an adequate theoretical rationale for these emerging problematic behaviors.
Relabáló/refrakter Hodgkin-lymphoma brentuximab vedotin kezelése. Hazai tapasztalatok
Authors: Molnár Zsuzsa , Pinczés László Imre , Piukovics Klára , Istenes Ildikó , Wolf Krisztina , Csukly Zoltán , Szomor Árpád , Illés Árpád , Miltényi Zsófia
Published: October 2017

Abstract:

Introduction: The treatment of relapsed or refractory Hodgkin lymphoma is still a major therapeutic challenge. The use of brentuximab vedotin, an anti-CD30 antibody-drug conjugate, represents a promising approach for these patients, however clinical outcomes have not yet been evaluated in Hungary. Aim: Our aim was to assess the efficacy, safety and outcome of brentuximab vedotin treatment in Hungarian Hodgkin lymphoma patients. Method: In this retrospective case note review we enrolled patients at 6 clinical sites countrywide who were diagnosed with Hodgkin lymphoma and received brentuximab vedotin between 1 January 2013 and 31 December 2016. Results: A total of 86 patients were treated with brentuximab vedotin during the examined period. Before therapy initiation 66% of our patients had advanced-stage disease. Overall response rate to brentuximab vedotin, administered before autologous hematopoietic stem cell transplantation (n = 54) was 66.6%, complete remission rate was 42.6%. Thirty patients received brentuximab vedotin after AHSCT, 46.67% responded to treatment, 30% achieved complete remission. Thirty-six patients received the drug as a single-agent therapy, 50 patients were given brentuximab vedotin in combination, 39 of them with bendamustin. Toxicity was observed only in 13.95% of our patients, most common symptom was skin rash. Based on our analysis the estimated 5-year overall survival rate was 78.7%, the estimated progression free survival rate was 23.59 months (95% CI: 19.50–27.68). Conclusion: Brentuximab vedotin carries a substantial improvement in the treatment of relapsed or refractory Hodgkin lymphoma. Our results underline prior observations published in the literature. The use of brentuximab vedotin in combination can be beneficial, however further investigation is needed on the subject. Orv Hetil. 2017; 158(41): 1630–1634.
A Waldenström-macroglobulinaemia és betegségre szabott kezelése
Authors: Szemlaky Zsuzsanna , Mikala Gábor
Published: October 2017

Abstract:

Waldenström’s macroglobulinaemia is a form of lymphoplasmocytic lymphoma that preferentially localizes to the bone marrow and causes a special syndrome characterized by monoclonal IgM hypersecretion. Recent results point to the fact that this disease has at least three different pathobiological forms with different clinical presentation. While mutations of MYD88 occur in 95–97% of the cases, there are CXCR4 mutations in 30–40%, ARID1A mutations in 17% and CD79B mutations in approximately 10% of afflicted individuals. CXCR pathway signaling is able to transcriptionally silence tumor suppressors induced by MYD88 activation. Patients with mutated MYD88 and CXCR4 present with higher tumor burden, slower developing and less deep response upon therapy with more frequent resistance. In this review, based on the most recent data, a treatment selection advice is provided for the therapy of symptomatic patients. Orv Hetil. 2017; 158(41): 1604–1614.
Percepción de la facultad de fiscalización de la administración tributaria y su relación con el cumplimiento de las obligaciones tributarias en las microempresas del parque comercial de Ceres, Ate, Lima, 2016
Authors: Díaz Estela Wiliam , Lobato Campos Jorge Luis
Published: October 2017

El propósito de la investigación fue determinar la relación que existe entre la percepción de la facultad de fiscalizaciónde la administración tributaria y el cumplimiento de las obligaciones tributarias en las microempresasdel parque comercial de Ceres, Ate, Lima, 2016. El tipo de estudio es correlacional y de diseño no experimental.Mediante la prueba de normalidad de Kolgomorov-Smirnov, se determinó que la distribución de ambas variablesno es normal, por lo tanto, se utilizó para la prueba de hipótesis el estadístico de Rho de Spearman. Losresultados según el coeficiente 0,408 (p-valor 0,000) indican una relación directa y significativa entre el nivel defiscalización con respecto al cumplimiento de obligaciones tributarias. Respecto a las dimensiones de la variablefiscalización y su relación con la variable cumplimiento de obligaciones tributarias se obtuvo un coeficiente de0,108 (p-valor = 0,088) para el nivel de investigación; un coeficiente de 0,249 (p-valor = 0,000) para el nivel deinspección y un coeficiente de 0,503 (p-valor = 0,000) para el nivel de control. En conclusión, según el estudiose concluye que existe una relación directa y significativa entre la percepción de la facultad de fiscalización dela administración tributaria de los pequeños empresarios que pertenecen a los diferentes regímenes tributariosy el cumplimiento de las obligaciones tributarias en las microempresas del parque comercial de Ceres, Ate, enLima para el año 2016. Es decir, cuanto más elevada es la percepción de la facultad de fiscalización de la administracióntributaria (SUNAT), respecto de los comerciantes del parque de Ceres-Ate, estos tienden a mejorar enel cumplimiento de las obligaciones tributarias.
Proyecto Museo Pedagógico Colombiano
Authors: Noguera R. Carlos Ernesto , Herrera B. Claudia Ximena
Published: October 2017

La Universidad Pedagógica Nacional, a través de su Facultad de Educación y en asocio con el Grupo interuniversitario de Historia de las Prácticas Pedagógicas en Colombia, se han propuesto la creación del Museo Pedagógico Colombiano, como un espacio para la recuperación de la memoria pedagógica nacional y la generación de reflexiones, discusiones e investigaciones alrededor de los problemas centrales de la educación y la pedagogía en Colombia.
Las meditaciones de palomar
Authors: Pedagógico de Medios Observatorio
Published: October 2017

A raíz de una serie de contrariedades intelectuales que no vale la pena recordar, el señor Palomar ha decidido que su principal actividad será mirar las cosas desde afuera. Un poco miope, distraído, introvertido, no cree pertenecer a ese tipo humano que suele ser calificado de observador. Y, sin embargo, siempre le ha ocurrido que ciertas cosas -una pared de piedra, una conchilla, una hoja, una tetera- se le presenten como solicitándole una atención minuciosa y prolongada: se pone a observarlas casi sin darse cuenta y su mirada comienza a recorrer todos los detales y no consigue desprenderse de ellos. El señor Palomar ha decidido que en adelante redoblará su atención: primero, no pasando por alto esos reclamos que le llegan de las cosas; segundo, atribuyendo a la operación de observar toda la importancia que merece.
La infancia en la perspectiva de las representaciones sociales
Authors: Delgadillo Ingrid
Published: October 2017

El grupo infancia y sociedad, del proyecto curricular Licenciatura en Educación Infantil de la Universidad Pedagógica Nacional, desde hace tres años trabaja alrededor de lo que implica para la infancia el proceso de socialización en los escenarios educativos, indaga sobre la construcción histórica de la representación social de la infancia, tomando como marco el ámbito europeo, integrando y releyendo los aportes que algunos historiadores del tema han planteado en nuestro contexto.En el escrito se reflexiona sobre la categoría de niñez entendida inicialmente como "adultos en miniatura", y el desplazamiento de dicha noción hacia los procesos de privatización de la infancia en los espacios familiares y escolares y la consecuente configuración de subjetividades ancladas tanto en el niño “hijo” como niño “alumno" a lo cual se denominará "niñez institucionalizada". A ese respecto se considera en los contextos europeo y colombiano, tres fenómenos socioculturales capitales en la construcción de la "infancia”; el surgimiento del Estado moderno, de la institución escolar y la aparición de una nueva afectividad hacia el niño. Así mismo, se deja abierto el tema, planteando cómo hoy la infancia está siendo comprometida, transformándose en razón a las relaciones que se establecen en la actualidad con el mundo massmediático y tecnológico, entre otros aspectos.