bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemberdayaan Perempuan Anggota Koperasi Purun Al-Firdaus Melalui Penerapan Smart Finance Application (SFIA)
Authors: Analisa Analisa , Nurhaeni Nurhaeni , Rezeki Yuliarti
Published: June 2024

Pendahuluan: Koperasi Purun Al-Firdaus memiliki beberapa permasalahan diantaranya sumber daya manusia  bagian keuangan tidak mampu mengoperasikan komputer dan melakukan pencatatan operasional keuangan meliputi penjualan, pembelian, penerimaan dan pengeluaran kas dengan benar. Pencatatan transaksi masih dilakukan secara manual. Hal ini, menyebabkan sering terjadi kehilangan buku catatan penjualan dan pengeluaran kas sehingga berdampak pada proses pertanggungjawaban laporan keuangan bulanan yang menjadi terkendala. Proses pemasaran pun masih dilakukan secara tradisional menggunakan pamflet dan status aplikasi chat yang berdampak pada pangsa pasar kerajinan purun ini terbatas di Kalimantan saja.Tujuan: Pengabdian kepada masyarakat dilakukan dengan tujuan memberikan pelatihan kepada anggota koperasi yang mayoritas adalah ibu rumah tangga yang memiliki kemampuan dalam menghasilkan kerajinan purun supaya bisa menggunakan Web aplikasi keuangan SFIA (Smart Financial Application)  dan web promosi serta, memberikan pendampingan dalam mengkreasikan model kerajinan purun.Metode: Metode Pelaksanaan yang dilakukan dengan sistem Warrior Four Missing melalui metode Missing Based Learned yang akan dilakukan secara luring.Hasil: Menunjukkan bahwa terdapat para pengrajin yang mampu menggunakan Smart Financial Application (SFiA) untuk pencatatan transaksi dan pembuatan laporan keuangan serta pengetalasean produk untuk dipasarkan di dalam web SFiA. Simpulan: Kegiatan pengabdian kepada masyarakat untuk pengrajin Purun Al-Firdaus ini dilaksanakan dengan beberapa tahapan warrior four mission meliputi motivation class, Coaching Class, Creative Class dan The Day Intercamp yang telah dilaksanakan dengan baik dan di ikuti oleh banyak peserta PKM.
ERBB4 stimulation as a therapeutic strategy for atrial myopathy and atrial fibrillation
Authors:   , Tubeeckx Michiel
Published: June 2024

Atrial myopathy often underlies atrial fibrillation, the most common cardiac arrhythmia, and induces continuing atrial remodeling, including atrial fibrosis, that is not targeted by current therapies. ERBB4 agonists have proven counteracting effects on ventricular fibrosis. With this thesis, we set up two different porcine models of atrial myopathy, to study the anti-fibrotic and anti-arrhythmic effects of the ERBB4 agonist JK07 in the atria of the animals.
The Phenomenon of Teachers’ Burnout: Its Implication for Job Satisfaction
Authors: De la Cruz Joanna Mae , Macalisang Denmark
Published: June 2024

Teachers play an indispensable role in the lives of children; however, in recent years, the demands of teaching have increased significantly. This study aims to determine the feelings of burnout among secondary public-school teachers in the District of Aloran, Division of Misamis Occidental. It examines the elements contributing to teacher burnout, its impact on job satisfaction, and the coping mechanisms teachers use to mitigate it. Informant teachers, who participated in one-on-one interviews, were employed during the 2023–2024 academic year and were identified as experiencing burnout based on the results of the Maslach Burnout Inventory. A transcendental phenomenological approach and a qualitative study design were employed. The findings reveal that concerns about academics, administration, and workload demands significantly contribute to teacher burnout, affecting their well-being and hindering their professional growth. To manage burnout, teachers utilize coping strategies such as seeking social support and engaging in self-care practices. The study proposes program interventions, including upgrading and continuing current programs that support and enhance teacher well-being, along with offering competitive compensation and benefits. These findings suggest that a holistic approach addressing equity and inclusion, enhancing teacher professional development, and promoting cooperation among stakeholders will transform the school system, providing high-quality, relevant, and inclusive education.
Sustainable Coastal Tourism Practices in Aklan: Bases for Policy Recommendations
Authors: Estuya Probee Bea , De Jose Tonylen
Published: June 2024

Aklan, one of the provinces in the Philippines, is known for its beautiful white beaches. Among its municipalities, Buruanga stands out with its immaculate white sand. This study examined the current state of coastal tourism, identified challenges and opportunities, and proposed policy recommendations for the effective implementation of sustainable practices in Aklan, Philippines. The research, conducted through a quantitative descriptive correlational design, involved 30 stakeholders, including resort owners, tourists, resort workers, municipal tourism officers, and local government officials. Data were collected using a researcher-made questionnaire and interviews. Findings revealed positive implementation of sustainable practices, particularly in policies, operations and management, socio-cultural aspects, products and services, and facilities. However, challenges persisted, such as changing existing practices and waste management. Despite these challenges, opportunities existed, including existing infrastructure and collaboration between stakeholders. Recommendations emphasized the need for strengthened waste management systems, updated policies, increased awareness campaigns, and community involvement. The study underscored a commitment to sustainable practices in Buruanga's coastal areas while identifying areas for improvement. Addressing these weaknesses can leverage existing strengths, contributing to a more environmentally responsible and economically viable tourism industry. Through its findings and recommendations, this research sought to inform policymakers, stakeholders, and communities, fostering sustainable tourism development in Buruanga, Aklan, and beyond.
LA SUSPENSIÓN TEMPORAL DEL RÉGIMEN DE DISOLUCIÓN POR PÉRDIDAS A RAÍZ DE LA PANDEMIA DEL COVID-19
Authors: Castillo Rovira Pablo
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
LA CUESTIÓN DEL ACTIVISMO ACCIONARIAL TRAS LA REGULACIÓN ESTABLE DE LA JUNTA GENERAL EXCLUSIVAMENTE TELEMÁTICA: DEL VOTO ELECTRÓNICO AL VOTO ROBOTIZADO
Authors: García Mandaloniz Marta
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
IMPLICACIONES DEL COVID-19 EN EL FENÓMENO CRIPTO. DE LAS CONSIDERACIONES SOCIOLÓGICAS AL CONOCIMIENTO Y CONSENTIMIENTO DEL INVERSOR
Authors: Blanco Sánchez María
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
LA REALIZACIÓN DE LA MASA ACTIVA EN FASE DE LIQUIDACIÓN CONCURSAL TRAS LA COVID-19
Authors: Ruiz Demetrio José
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
USING INTERACTIVE METHODS IN TEACHING ENGLISH AT THE UNIVERSITIES
Authors: Yulduzxon SAYDIBRAGIMOVA
Published: June 2024

This study explores the effectiveness of interactive teaching methods in enhancing English language education at universities. Employing a mixed-methods approach, the study investigates the impact of interactive techniques on language proficiency, student engagement, and satisfaction. Results indicate significant improvements in language skills among students who received instruction using interactive methods, alongside positive perceptions and experiences with interactive teaching. The findings underscore the importance of incorporating interactive approaches into language instruction to promote active learning, meaningful communication, and student empowerment. Implications for curriculum design, instructional practice, and educational policy are discussed, highlighting the practical significance of interactive methods in meeting the diverse needs of students in language education. Further research is warranted to explore long-term effects and extend findings across different contexts and learner demographics.
PELATIHAN PENANGANAN PASIEN GAWAT DARURAT YANG EFEKTIF DAN EFISIEN DI INSTALASI RADIOLOGI
Authors: Widya Mufida  , Faik Muhamad
Published: June 2024

Emergencies can be caused by disease, natural disasters and accidents. In the Radiology Installation, patients are no exception with emergencies that require immediate treatment due to trauma, illness or accidents experienced by the patient, apart from that the emergency situation that occurs in the Radiology Installation is that the patient has an allergic reaction to the contrast medium. The solution offered is training regarding handlers on radiographic examinations of emergency patients and first aid for patients who experience contrast media allergies. The training aims to improve soft skills and add insight to radiographers, alumni and D3 Radiology Study Program students by means of training in the effective and efficient handling of emergency patients at the Radiology Installation. From the results of the pretest and posttest, an increase of 20% was obtained, this shows success in increasing radiographers' understanding of handling patients in emergencies at radiology installations.
PKM EDUKASI POLA HIDUP SEHAT DAN KESEHATAN REPRODUKSI KEPADA MASYARAKAT DUSUN PULAU EMPAT DESA EMPAT BALAI KABUPATEN KAMPAR
Authors: Fauziah Nurul , Hidayati Nurkhairo , Mellisa  , Hajar Ibnu , Ferazona Sepita , Suryanti  , Robiah Siti , Yeyendra
Published: June 2024

Tujuan pengabdian kepada masyarakat ini adalah memberikan edukasi mngenai pola hidup sehat dan kesehatan reproduksi kepada masyarakat Dusun Pulau Empat. Metode pelaksanaan kegiatan pengabdian dengan cara wawancara, pemberian edukasi, diskusi, dan tanya jawab. Hasil kegiatan pengabdian masyarakat menunjukkan bahwa masyarakat Dusun Pulau Empat masih ada yang belum menjalankan pola hidup sehat dan masih ada yang belum memahami cara menjaga kesehatan organ reproduksi pada usia lanjut. Kesimpulannya adalah setelah dilakukannnya kegiatan pengabdian masyarakat masyarakat Dusun Pulau Empat ke depannya akan lebih konsisten dalam menjalankan pola hidup sehat dan lebih memperhatikan kesehatan organ reproduksi terutama pada usia lanjut.
EDUKASI POLITIK BAGI PEMILIH PEMULA DI DESA RIMBO PANJANG TAMBANG – KAMPAR
Authors: Rustam Afrinaldy , Afrizal  , Mashuri  , Khairunsyah  , Kafrina  , Mustiqowati  , Hastuti Weni Puji , Sehani  , Dewi Ratna , Asutri Fitri Ramashani , Canddra Pivit Sptiary , Emti Dewvi , Nurdiana  , Syarli Zikri Adilla
Published: June 2024

Studi ini bertujuan untuk menginvestigasi dampak edukasi politik terhadap pemilih pemula di Desa Rimbo Panjang Tambang, Kabupaten Kampar. Desa ini dipilih sebagai lokasi penelitian karena tingkat partisipasi pemilih pemula dalam proses politik seringkali rendah, yang bisa disebabkan oleh kurangnya pemahaman tentang politik dan kebijakan publik. Metode penelitian yang digunakan adalah survei dan wawancara dengan pemilih pemula dan pemangku kepentingan lokal.Hasil studi menunjukkan bahwa edukasi politik memiliki dampak yang signifikan terhadap pemilih pemula di Desa Rimbo Panjang Tambang. Sebelum mendapatkan edukasi politik, mayoritas pemilih pemula memiliki pemahaman yang terbatas tentang proses politik dan isu-isu penting. Namun, setelah mengikuti program edukasi politik, terjadi peningkatan yang signifikan dalam keterampilan berpikir kritis mereka, kemampuan untuk mengevaluasi informasi politik, dan partisipasi aktif dalam proses politik lokal.
DEVELOPING A DIGITAL PICTURE BOOK FOR SPEAKING COMPETENCE
Authors: Yani Safriyani Novitri , Satriani Estika , Piliang Wilda Srihastuty Handayani
Published: June 2024

This study aims to prepare a new product in the process of learning English, especially for semester 1 students. The product to be prepared is a digital picture book-based learning medium (e-book). Digital picture books (e-books) are made specifically to guide students to become more skilled in learning English according to ethical norms and customary values. Digital picture books or e-books will be packaged more independently and can be used directly by students with the help of the teacher or personally. This research uses the development method by adapting the IDI model, which has three stages of development: planning, design, and development. All processes will be adjusted based on the students' needs in terms of English skills. Quantitative data were collected through questionnaires and testing, and qualitative data were collected through interviews. To develop learning materials to offer students, researchers sought to find needs analysis, effectiveness, and practicality of the products in designing and implementing. Based on the research findings, the study was considered valid and practical and could be used to improve the quality of English comprehension among students.
ANALYSIS OF THE ROLE OF BUMDES AS AN EFFORTS TO EMPOWER VILLAGE COMMUNITIES
Authors: Oktari Widia , Desriadi  , Aidil Ridan , Syahputra Yogi
Published: June 2024

This research aims to investigate the role of Village-Owned Enterprises (Bumdes) in empowering the community on Kedungung Island, using a qualitative approach. Kedundung Island, representing a rural area, possesses substantial natural resources potential, yet often faces developmental challenges and limited access to resources. The research employs a qualitative approach through in-depth interviews, participatory observation, and document analysis. Bumdes is the primary subject, while the rural community of Kedungung Island serves as the research object. The qualitative approach allows researchers to gain a deeper understanding of the dynamics of interaction between Bumdes and the local community. The findings reveal that Bumdes plays a significant role in enhancing the well-being of the rural community on Kedundung Island. Through the qualitative approach, this research illustrates various contextual aspects such as local cultural values, government policies, and socio-economic dynamics that influence the role of Bumdes in community empowerment. Bumdes on Kedungung Island has proven successful in managing various local economic potentials, including agriculture, fisheries, and tourism, taking into account the needs and aspirations of the community. Collective business development initiatives by Bumdes not only increase community income but also strengthen a sense of ownership and responsibility towards village development.
Lipid Peroxidation and Detection of Pro-Inflammatory Variables in Rheumatoid Arthritis- A Comprehensive Analysis of Malondialdehyde and Isoprostanes in Synovial Fluids and SERA
Authors: Saeed UMER , Ali Mudassar , Mahmood Faheem , Saeed Saman , Mudassar Sahar , Ahmed Jamil
Published: June 2024

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation and joint destruction produced mostly by oxidative stress and lipid peroxidation. Analyzing markers for these processes is critical to understanding the etiology of RA. Objectives: The goal of this study is to assess the importance of the lipid peroxidation indicators malondialdehyde (MDA) and isoprostanes in RA synovial fluids and sera in indicating oxidative stress, as well as their potential diagnostic use. Methodology: We carried up cross-sectional analytical study with 60 participants, evenly divided between RA patients and healthy controls of the same age and gender. Malondialdehyde levels were measured spectrophotometrically using the thiobarbituric acid reactive substances (TBARS) method, and isoprostanes were quantified using commercially available ELISA kits. The samples were obtained at the Arif Clinical and Diagnostic Centre and examined in the biochemical labs of Rashid Latif Hospital in Lahore. Results: The study found that RA patients had significantly higher levels of MDA and isoprostanes in their serum (MDA: 1.95±0.094 µmol/ml; Isoprostanes: 12.26±5.26 pg/ml) and synovial fluid (MDA: 3.26±0.65 µmol/ml; Isoprostanes: 34.26±4.26 pg/ml) compared to controls (MDA: 0.95±0.019 µmol/ml; Synovial Fluid MDA: 0.019±0.0016). Conclusion: Elevated levels of MDA and isoprostanes in RA patients highlight their significance as oxidative stress indicators, representing the continuous inflammatory process and probable joint damage in RA. These findings lend credence to the diagnostic and prognostic value of lipid peroxidation products in the treatment of RA.
Unobtrusive Health Hazard
Authors: Shuja Naveed
Published: June 2024

Oxidative stress is a biological mechanism triggered by an imbalance between the biosynthesis and accumulation of reactive oxygen species (ROS) in a biological system. Normally, ROS are produced as byproducts of oxygen metabolism and fulfill various physiological roles such as cell signaling. However, environmental stressors like UV radiation, ionizing radiation, pollutants, heavy metals, and xenobiotics can also lead to increased ROS production. Common types of ROS include superoxide radicals (O2−), hydrogen peroxide (H2O2), hydroxyl radicals (•OH), and singlet oxygen (1O2), which are generated during various metabolic pathways. Key cellular processes such as protein phosphorylation, activation of transcriptional factors, apoptosis, immunity, and differentiation depend on maintaining appropriate levels of ROS within cells.
Under conditions of excessive ROS production, which can occur during both normal physiological processes and pathological conditions like inflammation, ischemia, and aging, ROS can damage important cellular components such as proteins, lipids, and nucleic acids. This production is primarily mitochondrial but can also result from enzymatic activities involved in the respiratory chain, prostaglandin synthesis, phagocytosis, and the cytochrome P450 system. Both immune system activation and environmental factors contribute to endogenous and exogenous free radical production.
The signs of oxidative stress include fatigue, memory loss, muscle or joint pain, the appearance of wrinkles and grey hair, decreased eyesight, headaches, increased sensitivity to noise, and a heightened susceptibility to infections. To reduce oxidative stress, it is advised to avoid sugar and processed foods while balancing blood sugar levels, prevent infections, incorporate daily stress reduction practices, avoid toxins, and promote the production of antioxidants through diet and herbal supplements that are rich in antioxidants.
Lytinio švietimo nuostatų Gyvenimo įgūdžių bendrojoje programoje vertinimas: visuomenės pozicija
Authors: Advilonienė Živilė
Published: June 2024

Straipsnyje analizuojamas visuomenės požiūris į lytiškumo ugdymo turinį Gyvenimo įgūdžių bendrojoje programoje. Remiantis skirtingų lytiškumo ugdymo paradigmų (rizikos vengimu grindžiamo pilnutinio, arba integralaus, lytiškumo ugdymo ir rizikos pasekmių kontrole grįsto dalinio, arba dezintegruoto, lytiškumo ugdymo) apžvalga gvildenamas klausimas, kokį nepilnamečių lytiškumo ugdymo modelį palaiko visuomenė. Straipsnyje pristatomi 2023 m. „Vilmorus“ atlikto reprezentatyvaus (N-1001) Lietuvos gyventojų tyrimo metu gauti duomenys apie visuomenės požiūrį į keturis aspektus, susijusius su Gyvenimo įgūdžių bendrojoje programoje pristatomo lytiškumo ugdymo turiniu. Tai – tėvų teisė savo vaikams parinkti šeimos įsitikinimus atitinkantį lytiškumo ugdymo turinį; nepilnamečių ugdymas atidėti lytinius santykius vėlesniam amžiui ir sieti juos su meile, ilgalaikiais santykiais ir šeimos kūrimu; pritarimas ar nepritarimas tam, kad būtų ugdoma nepilnamečių nuostata apie homoseksualių santykių tapatumą vyro ir moters santykiams; pritarimas ar nepritarimas mokinių supažindinimui su kontracepcija nuo 7 klasės. 2023 m. tyrimo duomenys lyginami su panašaus 2018 m. (N-1000) tyrimo, kuriuo siekta analizuoti visuomenės požiūrio kaitą, rezultatais. Abiejų tyrimų rezultatai atskleidė, kad Lietuvos gyventojai remia rizikos vengimu grindžiamą pilnutinį (integralų) lytiškumo ugdymą ir nepritaria unifikuotai rizikos pasekmių kontrole grįstai dalinio (dezintegruoto) lytiškumo ugdymo koncepcijai, įtvirtintai Gyvenimo įgūdžių bendrojoje programoje.
Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal Organ at Single Cell Resolution
Authors: Hills Max , Ma Limei , Fang Ai , Chiremba Thelma , Malloy Seth , Scott Allison , Perera Anoja , Yu C. Ron
Published: June 2024

We have generated single cell transcriptomic atlases of vomeronasal organs (VNO) from juvenile and adult mice. Combined with spatial molecular imaging, we uncover a distinct, previously unidentified class of cells that express the vomeronasal receptors and a population of canonical olfactory sensory neurons in the VNO. High resolution trajectory and cluster analyses reveal the lineage relationship, spatial distribution of cell types, and a putative cascade of molecular events that specify the V1r, V2r, and OR lineages from a common stem cell population. The expression of vomeronasal and olfactory receptors follow power law distributions, but there is high variability in average expression levels between individual receptor and cell types. Substantial co-expression is found between receptors across clades, from different classes, and between olfactory and vomeronasal receptors, with nearly half from pairs located on the same chromosome. Interestingly, the expression of V2r, but not V1r, genes is associated with various transcription factors, suggesting distinct mechanisms of receptor choice associated with the two cell types. We identify association between transcription factors, surface axon guidance molecules, and individual VRs, thereby uncovering a molecular code that guides the specification of the vomeronasal circuitry. Our study provides a wealth of data on the development and organization of the accessory olfactory system at both cellular and molecular levels to enable a deeper understanding of vomeronasal system function.
Redox takes control
Authors: Plaza-Menacho Iván
Published: June 2024

A study of two enzymes in the brain reveals new insights into how redox reactions regulate the activity of protein kinases.
Production Characteristics of Local Guinea Fowl (Numida Meleagris) in the Urban Commune of Tessaoua, Niger
Authors: Ousseini Moussa Hassan , Nouri Brah , Laminou Souley Garba Mahamadou
Published: June 2024

Guinea fowl breeding is an important source of animal protein and income for populations in Niger. Improving this activity requires better knowledge of production practices. Thus, a survey was carried out in August 2023 in the urban commune of Tessaoua (Maradi/Niger) in order to provide the necessary information on the practice of guinea fowl breeding. For this purpose, sixty (60) producers distributed in 6 villages (10 producers / villages) within a radius of 15km around the urban commune of Tessaoua were interviewed using a structured questionnaire. The results of this study show that guinea fowl breeding is an activity mainly carried out by men (86%). Guinea fowl (28.47%) are raised at the same time with chickens (60.08%), pigeons (6.74%), ducks (4.52%) and Turkey (0.20%). The predominant breeding system for local guinea fowl in the urban commune of Tessaoua is scavenging (77%). The guinea fowl most preferred by producers are respectively those with gray plumage (44%), gray plumage with white breast (23%), and those with ash plumage (21%). Guinea fowl breeding products are mainly intended for sale (45%), for self-consumption (36%) and donation (14%). Sixty-eight percent (68%) of producers do not vaccinate their poultry. This is why Newcastle disease is the most catastrophic for 52% of producers. The main constraints in guinea fowl breeding in the urban commune of Tessaoua are diseases (67%) and lack of resources (18%). It is clear that the development of the sector necessarily involves strengthening the surveillance of avian diseases, coupled with veterinary monitoring and supervision of producers.
Impact of Spacing on Soil Microbial Populations, Pest and Disease Incidence in Cocoa Cultivation
Authors: V Jegadeeswari. , Padmadevi K. , Vijayalatha K. R. , Mohanalakshmi M. , Kalaivani J. , Sidhdharth G.
Published: June 2024

Cocoa (Theobroma cacao) is a globally important commercial crop prized for its delicious and versatile beans used in chocolate production. However, cocoa cultivation faces significant challenges, including pest and disease outbreaks that can devastate yields and farmer livelihoods. One potential approach to managing these challenges is optimizing agricultural practices, including planting density or crop spacing. This study aimed to investigate the impact of different planting densities on these factors to identify an optimal spacing strategy that promotes a healthy soil microbiome, reduces pest and disease problems, and ultimately enhances cocoa yields. The experiment was laid out in Randomized Block Design (RBD) with eight treatments and three replications. Results revealed that T7 (2.5m) exhibited the lowest incidence of pod rot (0.48), while T6 (2m) had the least mealy bug infestation (0.55). Notably, T6 showed the highest bacterial population (7.33 × 106 CFU g-1), whereas T4 (3 x 3 m) and T7 (2.5m) demonstrated higher fungal populations (3.33 × 104 CFU g-1). Furthermore, T3 (3m x 2.5m) displayed the highest actinomycetes population (4.33 × 103 CFU g-1). These findings underscore the importance of spacing configurations in influencing soil microbial populations and pest and disease incidence in cocoa cultivation.
Cytarabine and clofarabine after high‐dose cytarabine in relapsed or refractory AML patients
Authors: Scappini Barbara , Gianfaldoni Giacomo , Caracciolo Francesco , Mannelli Francesco , Biagiotti Caterina , Romani Claudio , Pogliani Enrico M. , Simonetti Federico , Borin Lorenza , Fanci Rosa , Cutini Ilaria , Longo Giovanni , Susini Maria Chiara , Angelucci Emanuele , Bosi Alberto
Published: July 2012

Clofarabine has been shown to be effective in AML patients, either as single agent or, mainly, in association with intermediate dose cytarabine. Based on these reports, we conducted a preliminary study combining clofarabine and intermediate dose cytarabine in AML patients who relapsed or failed to respond to at least two induction therapies. We treated 47 patients affected by relapsed/refractory AML with a regimen including clofarabine at 22.5 mg/m2 daily on days 1–5, followed after 3 hr by cytarabine at 1 g/m2 daily on days 1–5. Ten patients received a further consolidation cycle with clofarabine at 22.5 mg/m2 and cytarabine at 1 g/m2 day 1–4. Among the 47 patients, 24/47 (51%) achieved a complete remission, 5/47 (10.5%) a partial response, 10/47 (21%) had a resistant disease, and 6/47 (13%) died of complications during the aplastic phase. The most frequent nonhematologic adverse events were vomiting, diarrhea, transient liver toxicity, febrile neutropenia, and infections microbiologically documented. Among the 24 patients who obtained a CR 13 underwent allogeneic bone marrow transplantation. In 14 patients, complete remission duration was shorter than 12 months, whereas 10 patients experienced longer complete remission duration. These very preliminary results suggest that clofarabine‐cytarabine regimen is effective in this particularly poor prognosis category of patients, representing a potential “bridge” toward bone marrow transplant procedures. Safety data were consistent with previously reported salvage therapies. Further studies and a longer follow up are warranted. Am. J. Hematol., 2012. © 2012 Wiley Periodicals, Inc.
Isolation and characterization of mesenchymal stem cells from whole human umbilical cord applying a single enzyme approach
Authors: Zhang Hao , Zhang Bin , Tao Yanling , Cheng Mei , Hu Jiangwei , Xu Man , Chen Hu
Published: July 2012

Mesenchymal stem cells (MSCs) are multipotent cells traditionally derived from bone marrow (BM). They have been demonstrated to be widely applied in tissue regeneration and cellular therapy. As an alternative to BM, an umbilical cord (UC) is considered as a potential source of MSCs. Here, we showed that human UC‐MSCs were easily isolated by a single enzymatic digestion and characteristic of plastic adherence and fibroblast‐like morphology. UC‐MSCs isolation was successful in 15 of 15 samples. The colony‐forming unit‐fibroblast frequency was obtained 54 ± 1.33 from 103 UC‐MSCs at passage 3, and the doubling time was (24.15 ± 0.49) h. Almost 1010 UC‐MSCs were largely produced in about 30 days. By flow cytometry analysis, the adherent cells displayed an abundant presence of CD73, CD90 and CD105 and absence of CD34, CD45 and HLA‐DR. When cultured in differentiation media, they can be differentiated into adipocytes, osteocytes and chondrocytes. RT‐PCR reactions confirmed that their multidifferentiation related genes were positive. Moreover, stem cell‐related transcription factors Nanog, Oct‐4 and Sox‐2 were positively expressed in UC‐MSCs. On the basis of these findings, the single enzyme method is a good method to obtain large‐scale production of MSCs from whole human UC in a short time, and the UC can be considered as a novel and convenient source of adult MSCs displaying high expansion potential and primitive pluripotent stem cells. Copyright © 2012 John Wiley & Sons, Ltd.
A Density Functional Theory Investigation of the Cobalt‐Mediated η5‐Pentadienyl/Alkyne [5+2] Cycloaddition Reaction: Mechanistic Insight and Substituent Effects
Authors: Ylijoki Kai E. O. , Budzelaar Peter H. M. , Stryker Jeffrey M.
Published: July 2012

Alkyl‐substituted η5‐pentadienyl half‐sandwich complexes of cobalt have been reported to undergo [5+2] cycloaddition reactions with alkynes to provide η2,η3‐cycloheptadienyl complexes under kinetic control. DFT studies have been used to elucidate the mechanism of the cyclization reaction as well as that of the subsequent isomerization to the final η5‐cycloheptadienyl product. The initial cyclization is a stepwise process of olefin decoordination/alkyne capture, CC bond formation, olefin arm capture, and a second CC bond formation; the initial decoordination/capture step is rate‐limiting. Once the η2,η3‐cycloheptadienyl complex has been formed, isomerization to η5‐cycloheptadienyl again involves several steps: olefin decoordination, β‐hydride elimination, reinsertion, and olefin coordination; also here the initial decoordination step is rate limiting. Substituents strongly affect the ease of reaction. Pentadienyl substituents in the 1‐ and 5‐positions assist pentadienyl opening and hence accelerate the reaction, while substituents at the 3‐position have a strongly retarding effect on the same step. Substituents at the alkyne (2‐butyne vs. ethyne) result in much faster isomerization due to easier olefin decoordination. Paths involving triplet states do not appear to be competitive.
Depression, Anxiety, and Quality of Life After Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
Authors: Sang Cai‐Hua , Chen Ke , Pang Xue‐Feng , Dong Jian‐Zeng , Du Xin , Ma Hui , Liu Ji‐Hong , Ma Chang‐Sheng , Sun Ying‐Xian
Published: July 2012

Background:

Patients with paroxysmal atrial fibrillation (AF) experience impaired quality of life (QoL) and psychological distress. Catheter ablation of AF can markedly improve QoL. However, the effect of catheter ablation of AF on psychological status is unknown.

Hypothesis:

Depression, anxiety, and QoL improve after catheter ablation in patients with paroxysmal AF.

Methods:

A total of 166 consecutive patients with symptomatic paroxysmal AF were examined. Eighty‐two patients (55 men, mean age 55.9 ± 6.1 y) underwent catheter ablation and 84 patients (58 men, mean age 57.2 ± 5.4 years) received antiarrhythmic drug (AAD) therapy. The Self‐Rating Depression Scale, Self‐Rating Anxiety Scale, and Medical Outcomes Survey 36‐item Short‐Form questionnaires were completed by these patients at baseline, and at 3, 6, 9, and 12 months of follow‐up. Results in the ablation group were compared with those of the AAD group.

Results:

In the ablation group, 42.7% of patients showed symptoms of depression and 37.8% showed symptoms of anxiety, which were similar to those in the AAD group. Both groups similarly displayed reduced physical and mental QoL. Catheter ablation was effective in reducing symptoms of depression and anxiety and improving QoL, and it was superior to AAD therapy (all P < 0.001). Multiple regression analysis demonstrated that catheter ablation, no AF recurrence, avoidance of warfarin use, higher baseline depression and anxiety scores, and lower baseline QoL scores contributed to improvement of depression, anxiety, and QoL, respectively.

Conclusions:

Catheter ablation is more effective for improving depression, anxiety, and QoL in patients with paroxysmal AF compared with AAD therapy. Clin. Cardiol. 2012 doi: 10.1002/clc.22039

This work was supported by grants from the National Science Foundation Council of China (No. 30971239 and No. 81070147) and the Beijing Natural Science Foundation (No. 7101004). The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Cyclosquaramides as Kinase Inhibitors with Anticancer Activity
Authors: Villalonga Priam , Fernández de Mattos Silvia , Ramis Guillem , Obrador‐Hevia Antònia , Sampedro Angel , Rotger Carmen , Costa Antoni
Published: July 2012

We report the synthesis and biological evaluation of a new series of oligosquaramide‐based macrocycles as anticancer agents. Compound 7, considered as representative of this series, exhibited significant antiproliferative activity against the NCI‐60 human tumor cell line panel, with IC50 values ranging from 1 to 10 μM. The results show that sensitivity to cyclosquaramides is clearly dependent on cell type, underscoring a degree of biological selectivity. The observed antiproliferative effects appear to be related to deregulation of protein phosphorylation, as compounds 7 and 8 are effective inhibitors of several important kinases such as ABL1, CDK4, CHK1, PKC, c‐MET, and FGFR, among others. The corresponding acyclic oligosquaramides and smaller cyclosquaramides did not show antitumor activity, suggesting that a macrocyclic structure with minimal molecular size plays a key role in the observed antitumor activity.
Backfilling with guarantees made as jobs arrive
Authors: Lindsay A. M. , Galloway‐Carson M. , Johnson C. R. , Bunde D. P. , Leung V. J.
Published: July 2012

In this paper, we present scheduling algorithms that simultaneously support guaranteed starting times and favor jobs with system‐desired traits. To achieve the first of these goals, our algorithms keep a profile with potential starting times for every unfinished job and never move these starting times later, just as in Conservative Backfilling. To achieve the second, they exploit previously unrecognized flexibility in the handling of holes opened in this profile when jobs finish early. We find that, with one choice of job selection function, our algorithms can consistently reduce average waiting time and average bounded slowdown relative to Conservative Backfilling while still providing a guaranteed start time to each job as it arrives. In fact, in most cases, the algorithms give better performance than the more aggressive Extensible Argonne Scheduling System (EASY) backfilling algorithm, which does not provide guaranteed start times. Alternately, with a different choice of job selection function, our algorithms can focus the benefit on the widest submitted jobs, the reason for the existence of parallel systems. In this case, these jobs experience significantly lower waiting times than Conservative Backfilling with minimal impact on other jobs. Copyright © 2012 John Wiley & Sons, Ltd.
Parallel implementation and performance analysis of a linear octree finite element mesh generation scheme
Authors: Camata Jose J. , Coutinho Alvaro L. G. A.
Published: July 2012

We show a parallel implementation and performance analysis of a linear octree‐based mesh generation scheme designed to create reasonable‐quality, geometry‐adapted unstructured hexahedral meshes automatically from triangulated surface models. We present algorithms for the construction, 2:1 balancing and meshing large linear octrees on supercomputers. Our scheme uses efficient computer graphics algorithms for surface detection, allowing us to represent complex geometries. An isogranular analysis demonstrates good scalability. Our implementation is able to execute the 2:1 balancing operations over 3.4 billion octants in less than 10 s per 1.6 million octants per CPU core. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis and optical properties of CuInS2 thin films prepared by sulfurization of electrodeposited Cu‐In layers
Authors: Chen Yu‐Cheng , Shi Jen‐Bin , Wu Po‐Feng , Chen Chih‐Jung , Yang Shui‐Yuang
Published: July 2012

The chalcopyrite CuInS2 thin film was fabricated at 500 °C for 2 h by sulfurization of Cu‐In layers (as precursors) that were sulfurized in a glass tube with pure sulfur powder. The structural, morphological, and optical properties of CuInS2 thin films are characterized using X‐ray diffraction (XRD), field‐emission scanning electron microscope (FE‐SEM), and UV/Visible/NIR spectrophotometer. The study of UV/Visible/NIR absorption shows the band gap energy value of CuInS2 thin films is 1.5 eV. The XRD pattern shows the film is pure CuInS2; no other peaks, such as CuS or CuIn5S8 were observed. Furthermore, the surface of the CuInS2 film is compact characterized by FE‐SEM, which also shows the disappearance of CuS on the surface at 500 °C.