bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Triethylammonium Acetate‐Mediated Domino‐Knoevenagel‐hetero‐Diels—Alder Reaction: Synthesis of Some Angular Polyheterocycles.
Authors: Parmar Narsidas J. , Pansuriya Bhavesh R. , Barad Hitesh A. , Parmar Bhagyashri D. , Kant Rajni , Gupta Vivek K.
Published: October 2013

The title reaction is performed in triethylammonium acetate which acts as catalyst and solvent.
ChemInform Abstract: Copper‐Catalyzed Domino SN2′/Coupling Reaction: A Versatile and Facile Synthesis of Cyclic Compounds from Baylis—Hillman Acetates.
Authors: Niu Qingsheng , Mao Hui , Yuan Guodong , Gao Jilong , Liu Haiquan , Tu Yawei , Wang Xiaoxia , Lv Xin
Published: October 2013

This is a versatile and simple method for the synthesis of quinoline, pyridine, benzothiopyran, and naphthalene derivatives from readily available starting materials.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Oxidative Stannylation of Aldehydes: A Facile Entry to Organotin(IV) Carboxylates.
Authors: Reddi Rambabu N. , Malekar Pushpa V. , Sudalai Arumugam
Published: October 2013

Aerobic oxidation followed by stannylation of the resulting carboxylic acids allows the preparation of the target compounds.
ChemInform Abstract: Growth, Crystal Structure and Spectrum of a Novel Rare‐Earth Orthophosphate Crystal: Yb:LuPO4.
Authors: Zhong De‐gao , Teng Bing , Cao Li‐feng , Chao Wang , He Lin‐xiang , Li Jian‐hong , Zhang Shi‐ming , Li Yu‐yi
Published: October 2013

Large single crystals of the title compound are prepared from mixtures of Lu2O3, Yb2O3, and PbHPO4 (Pt crucible, 1350 °C, 16 h).
ChemInform Abstract: Research Development on the Preparation of Gold‐Coated Magnetic Nanoparticles
Authors: Liu Yan
Published: October 2013

Review: 20 refs.
ChemInform Abstract: Electrocaloric Materials for Future Solid‐State Refrigeration Technologies
Authors: Valant Matjaz
Published: October 2013

Review: 141 refs.
ChemInform Abstract: Lycopodium Alkaloids — Synthetic Highlights and Recent Developments
Authors: Siengalewicz Peter , Mulzer Johann , Rinner Uwe
Published: October 2013

Review: 284 refs.
ChemInform Abstract: Synthesis of 3,4‐Disubstituted Pyrroles
Authors: Leeper Finian J. , Kelly James M.
Published: October 2013

Review: 145 refs.
ChemInform Abstract: Acyl Anion Free N‐Heterocyclic Carbene Organocatalysis
Authors: Ryan Sarah J. , Candish Lisa , Lupton David W.
Published: October 2013

Review: 50 refs.
ChemInform Abstract: Recent Advances in Isocyanide Insertion Chemistry
Authors: Qiu Guanyinsheng , Ding Qiuping , Wu Jie
Published: October 2013

Review: ca. 50 refs.
ChemInform Abstract: Recent Advances in the Synthesis and Properties of 4‐, 5‐, 6‐ or 7‐Azaindoles.
Authors: Merour Jean‐Yves , Routier Sylvain , Suzenet Franck , Joseph Benoit
Published: October 2013

Review: 247 refs.
ChemInform Abstract: Intermetallic Compounds Ce4Ru3Ga3 and La3Ru2Ga2 with Crystal Structures of New Types.
Authors: Shablinskaya Ksenia , Murashova Elena , Kurenbaeva Zhanafiya , Yaroslavtsev Alexander , Seropegin Yurii , Kaczorowski Dariusz
Published: October 2013

Ce4Ru3Ga3 (I) and La3Ru2Ga2 (II) are synthesized by arc melting of the elements under Ar followed by annealing (873 K, 30 d).
ChemInform Abstract: Na8Lu2(CO3)6F2 and Na3Lu(CO3)2F2: Rare Earth Fluoride Carbonates as Deep‐UV Nonlinear Optical Materials.
Authors: Luo Min , Ye Ning , Zou Guohong , Lin Chensheng , Cheng Wendan
Published: October 2013

The two new title compounds (IV) and (V) are characterized by single crystal XRD, UV/VIS diffuse reflectance spectroscopy, second harmonic generation measurements, and DFT computations.
ChemInform Abstract: A Novel Co‐Precipitation Method for One‐Pot Fabrication of a Co—Ni Multiphase Composite Electrode and Its Application in High Energy‐Density Pseudocapacitors.
Authors: Han Joah , Roh Kwang Chul , Jo Mi Ru , Kang Yong‐Mook
Published: October 2013

A multiphase composite film composed of Ni(OH)2 and Co(OH)2 is prepared electrochemically from LiOH solutions containing Co(NO3)2, Ni(NO3)2, and NH2OH (0.9 V, 25 °C, 24 h).
ChemInform Abstract: Magnetic, Transport and Electronic Properties of SmNi4Si Compound.
Authors: Falkowski M. , Pugaczowa‐Michalska M. , Kowalczyk A.
Published: October 2013

Polycrystalline SmNi4Si samples are investigated by powder XRD, magnetic susceptibility, magnetization, electrical resistivity, specific heat measurements, and by DFT electronic structure calculations.
ChemInform Abstract: Silica Sulfuric Acid‐Catalyzed Syntheses of Calix[4]resorcinarenes.
Authors: Zhao Ling‐ling , Wan Yu , Huang Shu‐ying , Liu Gui‐xiang , Chen Liang‐feng , Yue Shu‐ning , Zhang Wen‐li , Wu Hui
Published: October 2013

14 Title compounds of type (III) are prepared.
ChemInform Abstract: Highly Stereoselective Synthesis of Z‐Homoallylic Alcohols by Kinetic Resolution of Racemic Secondary Allyl Boronates.
Authors: Incerti‐Pradillos Celia A. , Kabeshov Mikhail A. , Malkov Andrei V.
Published: October 2013

An efficient kinetic resolution of secondary allyl bromides in the allylation of aldehydes is developed using a chiral binaphthyl derived phosphonic acid as the catalyst.
ChemInform Abstract: Synergistic Dual Activation Catalysis by Palladium Nanoparticles for Epoxide Ring Opening with Phenols.
Authors: Seth Kapileswar , Roy Sudipta Raha , Pipaliya Bhavin V. , Chakraborti Asit K.
Published: October 2013

The phenolysis of glycidyl ethers and other epoxides under utilization of Pd(II)‐chloride as precatalyst is described.
ChemInform Abstract: Copper‐Catalyzed Oxidation of Deoxybenzoins to Benzils under Aerobic Conditions.
Authors: Cacchi Sandro , Fabrizi Giancarlo , Goggiamani Antonella , Iazzetti Antonia , Verdiglione Rosanna
Published: October 2013

The process proceeds under neutral conditions using air as the oxidant and is tolerant to various functional groups.
ChemInform Abstract: cis‐2,3‐Disubstituted Cyclopropane 1,1‐Diesters in [3 + 2] Annulations with Aldehydes: Highly Diastereoselective Construction of Densely Substituted Tetrahydrofurans.
Authors: Yang Gaosheng , Sun Yongxian , Shen Yue , Chai Zhuo , Zhou Shuangliu , Chu Jiang , Chai Jun
Published: October 2013

A facile and highly stereoselective synthesis to pentasubstituted tetrahydrofuran derivatives, which are not easily accessible by other methods, is presented.
ChemInform Abstract: Broensted Acid‐Controlled [3 + 2] Coupling Reaction of Quinone Monoacetals with Alkene Nucleophiles: A Catalytic System of Perfluorinated Acids and Hydrogen Bond Donor for the Construction of Benzofurans.
Authors: Hu Yinjun , Kamitanaka Tohru , Mishima Yusuke , Dohi Toshifumi , Kita Yasuyuki
Published: October 2013

The reaction can also be performed in the presence of fluorinated terephthalic acid as catalyst albeit products are obtained in somewhat lower yields.
ChemInform Abstract: Cu(OTf)2‐Catalyzed Asymmetric Friedel—Crafts Alkylation Reaction of Indoles with Arylidene Malonates Using Bis(sulfonamide)‐Diamine Ligands.
Authors: Wu Jing , Wang Dongping , Wu Fan , Wan Boshun
Published: October 2013

It is also possible to perform the reaction on large scale with only 2.5 mol% catalyst loading.
ChemInform Abstract: Engaging Isatins in Solvent‐Free, Sterically Congested Passerini Reaction.
Authors: Kaicharla Trinadh , Yetra Santhivardhana Reddy , Roy Tony , Biju Akkattu T.
Published: October 2013

The Passerini reaction of isatins (I) with isocyanides and carboxylic acids affords desired oxindole derivatives such as (IV) and (VI).
ChemInform Abstract: A General Synthesis of Tetrahydropyrazolo[3,4‐d]thiazoles.
Authors: Pelletier Sophie , Pinson Benjamin , Smejkal Tomas , Lamberth Clemens
Published: October 2013

The short three step synthesis of the title compounds (VIII) allows the introduction of a wide range of substituents.
ChemInform Abstract: Synthesis and Antifungal Activity of 3‐(1,3,4‐Oxadiazol‐5‐yl)‐indoles and 3‐(1,3,4‐Oxadiazol‐5‐yl)methyl‐indoles.
Authors: Zhang Ming‐Zhi , Mulholland Nick , Beattie David , Irwin Dianne , Gu Yu‐Cheng , Chen Qiong , Yang Guang‐Fu , Clough John
Published: October 2013

A modified synthetic route affords the novel title compounds.
ChemInform Abstract: A Convenient One‐Pot Access to Phenanthridinones via Suzuki—Miyaura Cross‐Coupling Reaction
Authors: Tanimoto Kouichi , Nakagawa Naomichi , Takeda Kazutaka , Kirihata Mitsunori , Tanimori Shinji
Published: October 2013

o‐bromobenzoic acid methyl esters with o‐aminophenylboronic acids
ChemInform Abstract: A Palladium‐Catalyzed Coupling of 3‐Chloroquinoxalinones with Various Nitrogen‐Containing Nucleophiles.
Authors: Brachet Etienne , Peyrat Jean‐Francois , Brion Jean‐Daniel , Messaoudi Samir , Alami Mouad
Published: October 2013

Application of this general method is demonstrated in the synthesis of cannabinoid CB2 receptor antagonist (VIc).
ChemInform Abstract: Substituent‐Controlled Domino‐Henry‐hetero Diels—Alder Reaction: Synthesis of Polycyclic Nitronates.
Authors: Biswas Pritam , Ghosh Jaydip , Maiti Sourav , Banerjee Subhabrata , Bandyopadhyay Chandrakanta
Published: October 2013

The reaction of chromone‐3‐carbaldehydes (I) with nitromethane under conditions A) yields only functionalized nitroalkenes instead of the expected nitronates.
ChemInform Abstract: Palladium‐Catalyzed Ring‐Opening of Cyclopropyl Benzamides: Synthesis of Benzo[c]azepine‐1‐ones via C(sp3)—H Functionalization.
Authors: Ladd Carolyn L. , Roman Daniela Sustac , Charette Andre B.
Published: October 2013

A new synthesis of biologically relevant benzo[c]azepins is achieved via a novel Pd/Ag‐catalyzed intramolecular cyclization of ortho halogenated N‐cyclopropyl benzamides.
ChemInform Abstract: Chemical Design of Nanocrystal Solids
Authors: Kovalenko Maksym V.
Published: October 2013

Review: 65 refs.
ChemInform Abstract: Isomers in the Chemistry of Iron Carbonyls
Authors: Melnik Milan , Valentova Jindra , Devinsky Ferdinand
Published: October 2013

Review: 57 refs.
ChemInform Abstract: Aerobic Copper‐Catalyzed Organic Reactions
Authors: Allen Scott E. , Walvoord Ryan R. , Padilla‐Salinas Rosaura , Kozlowski Marisa C.
Published: October 2013

Review: 1557 refs.
ChemInform Abstract: Nitroderivatives of Catechol: From Synthesis to Application
Authors: Gavazov Kiril B.
Published: October 2013

Review: 206 refs.
ChemInform Abstract: Carbene Catalysis. Beyond the Benzoin and Stetter Reactions
Authors: Cardinal‐David Benoit , Scheidt Karl A.
Published: October 2013

Review: 174 refs.
ChemInform Abstract: Developing Catalytic Asymmetric Acetalizations
Authors: Coric Ilija , Vellalath Sreekumar , Mueller Steffen , Cheng Xu , List Benjamin
Published: October 2013

Review: 58 refs.
ChemInform Abstract: Decarboxylative Coupling Reactions
Authors: Goossen Lukas J. , Goossen Kaethe
Published: October 2013

Review: 89 refs.
ChemInform Abstract: Unique Structure and Solute ‐ Solvent Interaction in Imidazolium Based Ionic Liquids
Authors: Gonfa G. , Bustam M. A. , Man Z. , Abdul Mutalib M. I.
Published: October 2013

Review: 100 refs.
ChemInform Abstract: Fluorine‐18 Labeled Amino Acids for Oncologic Imaging with Positron Emission Tomography
Authors: Huang Chaofeng , McConathy Jonathan
Published: October 2013

Review: 155 refs.
ChemInform Abstract: Design of Medium Band Gap Ag—Bi—Nb—O and Ag—Bi—Ta—O Semiconductors for Driving Direct Water Splitting with Visible Light.
Authors: Wang Limin , Cao Bingfei , Kang Wei , Hybertsen Mark , Maeda Kazuhiko , Domen Kazunari , Khalifah Peter G.
Published: October 2013

Polycrystalline “AgBiNb2O7” (I) and “Ag4/5Bi5/6Ta2O6.65” (II) are synthesized by solid state reaction of Ag2O, Bi2O3, Nb2O5, and Ta2O5 in molar ratios of 0.5:0.5:1 for (I) and 0.4:0.418:1 for (II), resp.
ChemInform Abstract: High Efficient Photocatalytic Selective Oxidation of Benzyl Alcohol to Benzaldehyde by Solvothermal‐Synthesized ZnIn2S4 Microspheres under Visible Light Irradiation.
Authors: Chen Zhixin , Xu Jingjing , Ren Zhuyun , He Yunhui , Xiao Guangcan
Published: October 2013

Hexagonal ZnIn2S4 samples are solvothermally synthesized from mixtures of ZnCl2, InCl3, and excess thiacetamide dispersed in EtOH (autoclave, 433 K, 24 h).
ChemInform Abstract: Mixed‐Valence Uranium(V,VI) and Uranyl Oxyhydroxides Synthesized under High‐Temperature, High‐Pressure Hydrothermal Conditions: Na5[U5O16(OH)2] and Na5[U5O17(OH)].
Authors: Liu Hsin‐Kuang , Lii Kwang‐Hwa
Published: October 2013

The mixed‐valence uranium(V,VI) oxyhydroxide Na5[U5O16(OH)2] is prepared via reduction of UO22+ under hydrothermal conditions using UO3, NaOH, Na2MoO4 (mineralizer), and Zn as reductant (autoclave, gold ampoule, 570 °C and 150 MPa, 2 d, 50% yield).
ChemInform Abstract: Exploring the Assembly of Supramolecular Polyoxometalate Triangular Morphologies with Johnson Solid Cores: [(MnII(H2O)3)2 (K@{α‐GeW10MnII2O38 }3)]19‐.
Authors: Molina Pedro I. , Miras Haralampos N. , Long De‐Liang , Cronin Leroy
Published: October 2013

K8Li11 [(Mn(H2O)3)2 (K@{α‐GeW10Mn2O38}3)] ·35H2O is prepared by adding aqueous LiCl and MnCl2 to K8[γ‐GeW10O36]·6H2O under vigurous stirring (pH 7.6 adjusted with 1M NaOH, 80 °C, 10 min) followed by crystallization at 18 °C (21% yield based on W).
ChemInform Abstract: Cross Metathesis of Allyl Alcohols: How to Suppress and How to Promote Double Bond Isomerization.
Authors: Schmidt Bernd , Hauke Sylvia
Published: October 2013

Cross metathesis of allyl alcohols (I) and methyl acrylate (II) under standard conditions is accompanied by formation of ketones (IV), resulting from uncontrolled double bond isomerization.
ChemInform Abstract: Homologative Trifluoromethylation of Acetals.
Authors: Hamilton James Y. , Morandi Bill , Carreira Erick M.
Published: October 2013

A method to synthesize different substituted α‐trifluoromethyl acetals via an insertion strategy is developed.
ChemInform Abstract: Palladium‐Catalyzed Regioselective and Stereoselective Oxidative Heck Arylation of Allylamines with Arylboronic Acids.
Authors: Zhang Lingjuan , Dong Chaonan , Ding Chenjun , Chen Jing , Tang Weijun , Li Huanrong , Xu Lijin , Xiao Jianliang
Published: October 2013

A general and convenient method for the oxidative Heck arylation of both N‐mono‐ and N,N‐diprotected allylic amines under mild conditions is developed.
ChemInform Abstract: Graphene Oxide as a Recyclable Phase Transfer Catalyst.
Authors: Kim Youngmin , Some Surajit , Lee Hyoyoung
Published: October 2013

Graphene oxide (GO) shows competitive phase transfer catalytic properties in Michael additions to nitroalkenes compared to the established 18‐crown‐6 ether.
ChemInform Abstract: Mild Rhodium(III)‐Catalyzed Direct C—H Allylation of Arenes with Allyl Carbonates.
Authors: Wang Honggen , Schroeder Nils , Glorius Frank
Published: October 2013

Allylic carbonates are useful reagents for the ortho‐directed allylation of a variety of aromatic carboxylic N,N‐diisopropylamides in the presence of a Rh/Ag‐mixed catalyst.
ChemInform Abstract: Ru(II)‐Catalyzed Intermolecular C—H Amidation of Weakly Coordinating Ketones.
Authors: Zheng Qing‐Zhong , Liang Yu‐Feng , Qin Chong , Jiao Ning
Published: October 2013

No additional oxidant is necessary for the reaction.
ChemInform Abstract: Efficient Ruthenium‐Catalyzed S—S, S—Si and S—B Bond Forming Reactions.
Authors: Fernandez‐Salas Jose A. , Manzini Simone , Nolan Steven P.
Published: October 2013

An efficient and general method for synthesis of disulfides, thioboranes, and silylthioethers under mild dehydrogenation reaction conditions is presented.
ChemInform Abstract: Synthesis and Biological Evaluation of 4‐Arylphthalazones Bearing Benzenesulfonamide and Anti‐Inflammatory and Anticancer Agents.
Authors: Yaseen Shafiya , Ovais Syed , Bashir Rafia , Rathore Pooja , Samim Mohammed , Singh Surender , Nair Vinod , Javed Kalim
Published: October 2013

The synthesized compounds are tested for their anti‐inflammatory and anticancer activities.
ChemInform Abstract: Facile Construction of Biaryls by Homocoupling of Aryl Halides
Authors: Hajipour Abdol R. , Abrishami Fatemeh
Published: October 2013

using an ortho‐palladated complex as catalyst
ChemInform Abstract: Viologen as Catalytic Organic Reductant: Electro‐Reductive Dimerization of Aryl Bromides in a Pd/Viologen Double Mediatory System.
Authors: Kuroboshi Manabu , Shiba Takuya , Tanaka Hideo
Published: October 2013

The Pd‐catalyzed electro‐reductive coupling of aryl bromides is achieved using a small amount of viologen additive as an in situ recyclable organic reductant.
ChemInform Abstract: Asymmetric Synthesis of Trifluoromethylated Aziridines from CF3‐Substituted N‐tert‐Butanesulfinyl Ketimines.
Authors: Yang Yanmei , Huang Yangen , Qing Feng‐Ling
Published: October 2013

Chiral CF3‐substituted ketimines react with sulfur ylides generated in situ from iodide (I) to produce aziridines with good diastereoselectivties.
ChemInform Abstract: Synthesis of a Novel Class of Benzofurans via a Three‐Component, Regiospecific Intramolecular Heterocyclization Reaction.
Authors: Karami Bahador , Khodabakhshi Saeed , Hashemi Fatemeh
Published: October 2013

An operationally simple protocol is developed for the three component reaction of arylglyoxals, phenolic substrates, and benzamide in the presence of tungstate sulfuric acid as safe and recyclable solid catalyst to yield benzofuran derivatives.
ChemInform Abstract: Electrophilic Cyclization of o‐Anisole‐ and o‐Thioanisole‐Substituted Ynamides: Synthesis of 2‐Amidobenzofurans and 2‐Amidobenzothiophenes.
Authors: Kong Yulong , Yu Lian , Fu Lingzi , Cao Jian , Lai Guoqiao , Cui Yuming , Hu Ziqiang , Wang Guanhai
Published: October 2013

A simple protocol allows the electrophilic cyclization of the title ynamides with iodine, NBS, or NCS to provide benzofurane and benzothiophene derivatives.
ChemInform Abstract: A Mild Synthesis of N‐Functionalized Bromomaleimides, Thiomaleimides and Bromopyridazinediones.
Authors: Caddick Stephen , et al. et al.
Published: October 2013

A simple procedure allows the synthesis of N‐functionalized bromomaleimides from substrates (I) or (X) and various amines.
ChemInform Abstract: Regioselective Arene Halogenation Using the FAD‐Dependent Halogenase RebH.
Authors: Payne James T. , Andorfer Mary C. , Lewis Jared C.
Published: October 2013

A biocatalytic method using the tryptophan‐7‐halogenase RebH is developed for the highly regioselective halogenation of indoles and electron rich naphthalenes.
ChemInform Abstract: Synthesis of New Aryl‐Substituted Tandospirone and Epiboxidine Analogues and Isoxazoline Derivatives.
Authors: Kulu Irem , Goksu Gokce , Sucu Bilgesu Onur , Kopruceli Asli , Ocal Nuket , Kaufmann Dieter E.
Published: October 2013

New tandospirone [cf.(IIIa)—(IIId)] and epiboxidine analogues [cf.
ChemInform Abstract: Synthesis and Biological Evaluation of Pyrazoline Derivatives Bearing an Indole Moiety as New Antimicrobial Agents.
Authors: Oezdemir Ahmet , Altintop Mehlika Dilek , Kaplancikli Zafer Asim , Turan‐Zitouni Guelhan , Karaca Huelya , Tunali Yagmur
Published: October 2013

The compound (IIIc) shows promising activity against K.
ChemInform Abstract: Pd‐Catalyzed N‐Arylation of 2‐Imidazolines Provides Convenient Access to Selective Cyclooxygenase‐2 Inhibitors.
Authors: Krasavin Mikhail
Published: October 2013

Various imidazole derivatives of type (III) and compound (X) are prepared with a Pd‐catalyzed N‐arylation as key step.
ChemInform Abstract: Synthesis of New N‐Substituted 5‐Arylidene‐2,4‐thiazolidinediones as Antiinflammatory and Antimicrobial Agents.
Authors: Nastasa Cristina , Tiperciuc Brindusa , Parvu Alina , Duma Mihaela , Ionut Ioana , Oniga Ovidiu
Published: October 2013

The products (III) are screened in vitro for their anti‐inflammatory activity and their antimicrobial activities against Gram‐positive and ‐negative bacteria and one fungal strain.
ChemInform Abstract: Pd‐Catalyzed ortho‐C—H Acylation/Cross Coupling of 2‐Arylbenzo[d]thiazoles with Aldehydes Using tert‐Butyl Hydroperoxide as Oxidant.
Authors: Wang Jian , Nie Ziyi , Li Yan , Tan Shuang , Jiang Jiantao , Jiang Pusheng , Ding Qiuping
Published: October 2013

This strategy can be used for the direct synthesis of aromatic ketones from aldehydes and is compatible with a variety of functional groups including electron‐donating and ‐withdrawing groups attached to both 2‐arylbenzo[d]thiazoles and aldehydes.
ChemInform Abstract: Highly Enantioselective [4 + 2] Annulation via Organocatalytic Mannich‐Reductive Cyclization: One‐Pot Synthesis of Functionalized Piperidines.
Authors: Kumar Indresh , Ramaraju Panduga , Mir Nisar A. , Singh Deepika , Gupta Vivek K. , Rajnikant Rajnikant
Published: October 2013

The practicability of the described method is illustrated by gram‐scale application and through the synthesis of a functionalized (‐)‐anabasine derivative (IV*).
ChemInform Abstract: InCl3‐Catalyzed Green Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐diones under Solvent‐Free Conditions.
Authors: Reddy Mudumala Veeranarayana , Jeong Yeon Tae
Published: October 2013

The procedure allows the access to various biologically interesting title compounds in high yields within a short time.
ChemInform Abstract: Synthesis of 8,9‐Dihydro[1,2,4]triazolo[1,5‐a]quinazolin‐6(7H)‐one Derivatives.
Authors: Petrov A. A. , Kasatochkin A. N.
Published: October 2013

The title compounds (III) and (VI) are regioselectively obtained in a two‐component condensation of 2‐substituted 1H‐1,2,4‐triazol‐3‐amines (I) with 2‐acyl‐5,5‐dimethylcyclohexane‐1,3‐diones (II) and three‐component reaction of aminotriazole (Ia) with dimedone and dimethylformamide dimethyl acetal.
ChemInform Abstract: Microwave‐Assisted Synthesis and Bioactivities of Novel Quinoline Lactones.
Authors: Zheng Hui , Liu Juan , Shi Qiaoyue , Mei Yijia , Du Kui , Zhang Pengfei
Published: October 2013

Newly synthesized title compounds (II) are screened for their antibacterial and antifungal activities (only few data given).
ChemInform Abstract: Synthesis of Some Monoselenolipoic Acid Derivatives and Their Biological Evaluation as Anticancer Agents.
Authors: Xu Feng , Yang Zhen Zhen , Jiang Jun Rong
Published: October 2013

An efficient and green one‐pot synthesis of 6‐selenolipoic acid (II) is developed.
ChemInform Abstract: Nocapyrones H—J, 3,6‐Disubstituted α‐Pyrones from the Marine Actinomycete Nocardiopsis sp. KMF‐001.
Authors: Kim Min Cheol , Kwon Oh‐Wook , Park Jin‐Soo , Kim Sun Yeou , Kwon Hak Cheol
Published: October 2013

Nocapyrone H (Ia) reduces the pro‐inflammatory factor and shows stronger inhibitory effect on NO production than chrysin in lipopolysaccharide‐stimulated BV‐2 microglial cells.
ChemInform Abstract: Highly Uniform α‐NaYF4:Yb/Er Hollow Microspheres and Their Application as Drug Carrier.
Authors: Han Yunhua , Gai Shili , Ma Ping'an , Wang Liuzhen , Zhang Milin , Huang Shaohua , Yang Piaoping
Published: October 2013

α‐NaYF4:Yb/Er hollow microspheres are prepared via a two‐step route.
ChemInform Abstract: Thermodynamic Modeling of the Sr—X (X: H, Li, Na, Sc) Systems
Authors: Chen Chong , Wang Man , Du Yong , Gao Qiannan , Hu Biao , Liu Shuhong
Published: October 2013

Review: 46 refs.
ChemInform Abstract: New Applications for Bismuth(III) Salts in Organic Synthesis: from Bulk Chemicals to Steroid and Terpene Chemistry
Authors: Salvador J. A. R. , Silvestre S. M. , Pinto R. M. A. , Santos R. C. , LeRoux C.
Published: October 2013

Review: 138 refs.
ChemInform Abstract: Bismuth Salts in Catalytic Alkylation Reactions
Authors: Rueping Magnus , Nachtsheim Boris J.
Published: October 2013

Review: 90 refs.
ChemInform Abstract: Environmentally Friendly Organic Synthesis Using Bismuth(III) Compounds
Authors: Krabbe Scott W. , Mohan Ram S.
Published: October 2013

Review: 122 refs.
ChemInform Abstract: Mechanism of Palladium‐Catalyzed Suzuki—Miyaura Reactions: Multiple and Antagonistic Roles of Anionic “Bases” and Their Countercations
Authors: Amatore Christian , Le Duc Gaetan , Jutand Anny
Published: October 2013

Review: <80 refs.
ChemInform Abstract: Multipurpose Applications of Coumarin Derivatives with Special Emphasis on the Fluorescent Probes
Authors: Guha Subarna , Dutta Mili , Das Debasis
Published: October 2013

Review: 252 refs.
ChemInform Abstract: On‐Chip Catalytic Microreactors for Modern Catalysis Research
Authors: Xu Bin‐Bin , Zhang Yong‐Lai , Wei Shu , Ding Hong , Sun Hong‐Bo
Published: October 2013

Review: 103 refs.
ChemInform Abstract: Bio‐inspired Oxidations: Innovative Catalytic Strategies
Authors: Sartorel Andrea , Carraro Mauro , Bonchio Marcella
Published: October 2013

Review: 62 refs.
ChemInform Abstract: Non‐conventional Techniques in Organic Synthesis
Authors: Gruttadauria Michelangelo
Published: October 2013

Review: application of non‐conventional techniques for synthesis such as ball milling, use of supported ionic liquids, supported organocatalysts, and reactions under low conditions; 47 refs.
ChemInform Abstract: Porous Protein Crystals as Reaction Vessels
Authors: Ueno Takafumi
Published: October 2013

Review: 45 refs.
ChemInform Abstract: Selective Orexin Receptor Antagonists
Authors: Lebold Terry P. , Bonaventure Pascal , Shireman Brock T.
Published: October 2013

Review: 93 refs.
ChemInform Abstract: Review of Graphene‐Supported Metal Nanoparticles as New and Efficient Heterogeneous Catalysts
Authors: Blanita Gabriela , Lazar Mihaela D.
Published: October 2013

Review: 27 refs.
ChemInform Abstract: Nanocatalysis in Water
Authors: Baig R. B. Nasir , Varma Rajender S.
Published: October 2013

Review: 332 refs.
Catalytic Mechanism of Cytochrome P450 2D6 for 4‐Hydroxylation of Aripiprazole: A QM/MM Study
Authors: Shi Rongwei , Li Weihua , Liu Guixia , Tang Yun
Published: October 2013

Drug metabolism is an important issue in drug discovery. Understanding how a drug is metabolized in the body will provide helpful information for lead optimization. Cytochrome P450 2D6 (CYP2D6) is a key enzyme for drug metabolism and responsible for the metabolism of about one third marketed drugs. Aripiprazole is an atypical antipsychotic and metabolized by CYP2D6 to its hydroxylated form. In this study, a series of computational methods were performed to understand how CYP2D6 accomplishes the 4‐hydroxylation of aripiprazole. Molecular docking and molecular dynamics simulations were first performed to prepare the initial conformations for QM/MM calculations. The results revealed two possible conformations for the drug‐CYP2D6 complex. The ONIOM method for QM/MM calculations was then carried out to show detailed reaction pathways for the CYP2D6‐catalyzed aripiprazole hydroxylation reaction, which demonstrated that the dominant reactive channel was electrophilic and involved an initial attack on the π‐system of the dichlorophenyl group of aripiprazole to produce cation δ‐complex. Furthermore, the product complex for each conformation was thermodynamically stable, which is in good agreement with previous reports.
Synthesis and Anti‐HIV Activity of a Series of 6‐Modified 2′,3′‐Dideoxyguanosine and 2′,3′‐Didehydro‐2′,3′‐dideoxyguanosine Analogs
Authors: Xie Lujia , Yang Xiantao , Pan Delin , Cao Yingli , Cao Mou , Lin Guichun , Guan Zhu , Guo Ying , Zhang Lihe , Yang Zhenjun
Published: October 2013

In search of potential 2′,3′‐dideoxyguanosine (ddG) and 2′,3′‐didehydro‐2′,3′‐dideoxyguanosine (D4G) prodrugs, a series of 6‐modified ddG, D4G analogs were synthesized and evaluated for their anti‐HIV activities and cytotoxities in cell‐based assays. All analogs showed low cytotoxicities and some of them displayed benign anti‐HIV activities. The active triphosphate forms in vivo, ddGTP and D4TTP, were also synthesized by a novel and facile "one‐pot" method. The recognition of ddGTP and D4TTP by Taq, Therminater DNA polymerase and HIV reverse transcriptase (RT) incorporated in DNA/RNA strands were investigated by a non‐radioactivity method and Km were determined.
Synthesis, Biological Activity Evaluation and Molecular Modeling Study on the New Isoconessimine Derivatives as Acetylcholinesterase Inhibitors
Authors: Jin Guofei , Yang Zhongduo , Xue Weiwei , Sheng Jie , Shi Yin , Yao Xiaojun
Published: October 2013

New isoconessimine derivatives were synthesized from conessine (1) and evaluated as acetylcholinesterase (AChE) inhibitors. The derivatives were prepared via two reaction steps, N‐demethylation and nucleophilic substitution. All of the synthesized derivatives exhibited more potential anti‐acetylcholinesterase activities than conessine (1) (IC50=16 µmol·L−1) and isoconessimine (2) (IC50>300 µmol·L−1). Compound 7b (3β‐[methyl‐[2‐(4‐nitrophenoxy)ethyl]amino]con‐5‐enine) showed the most potent inhibitory activity with an IC50 of 110 nmol/L which is close to that of reference compound huperzine A (IC50=70 nmol/L). The mode of AChE inhibition by 7b was reversible and non‐competitive. In addition, molecular modeling was performed to explore the binding mode of inhibitor 7b at the active site of AChE and the results showed that 7b could be docked into the acetylcholinesterase active site and compound 7b had hydrophobic interactions with Trp279 and Leu282.
Economic feasibility of multipath protocols in mobile Internet of Things applications
Authors: Sonntag Sebastian , Suomi Henna
Published: October 2013

Internet of Things envisions some services that require both end‐device mobility and high availability or high bandwidth. However, the current environment with a cellular network and single‐path protocols may not guarantee a sufficient service level. Thus, this study evaluates the economic feasibility of using multipath protocols for increased availability and bandwidth when contracting with several cellular operators. By using cost‐efficiency analysis, a model is developed for comparing multipath protocols with their single‐path alternatives. The usage of the model is demonstrated with two potential mobile application scenarios that could benefit either from increased availability or bandwidth. Finland is used as an example market. The benefits of multipath protocols were quantified with an extensive set of handset‐based measurements from Finnish cellular networks. The results of this study indicate that the initial costs of a multipath infrastructure remain relatively small, and the total costs rapidly approach the operational costs as the number or active time of smart devices increase. Therefore, this study indicates that multipath protocols are economically feasible for certain mobile Internet of Things applications, particularly those requiring high bandwidth. Thus, new service models emerging in the Internet could create a real demand for multipath protocols in the future. Copyright © 2013 John Wiley & Sons, Ltd.
Facilitated Transport in Hydroxide‐Exchange Membranes for Post‐Combustion CO2 Separation
Authors: Xiong Laj , Gu Shuang , Jensen Kurt O. , Yan Yushan S.
Published: October 2013

Hydroxide‐exchange membranes are developed for facilitated transport CO2 in post‐combustion flue‐gas feed. First, a correlation between the basicity of fixed‐site functional groups and CO2‐separation performance is discovered. This relationship is used to identify phosphonium as a promising candidate to achieve high CO2‐separation performance. Consequently, quaternary phosphonium‐based hydroxide‐exchange membranes are demonstrated to have a separation performance that is above the Robeson upper bound. Specifically, a CO2 permeability as high as 1090 Barrer and a CO2/N2 selectivity as high as 275 is achieved. The high performance observed in the membranes can be attributed to the quaternary phosphonium moiety.
Thermoelectric Properties and Electronic Structure of the Zintl‐Phase Sr3AlSb3
Authors: Zevalkink Alex , Pomrehn Gregory , Takagiwa Yoshiki , Swallow Jessica , Snyder G. Jeffrey
Published: October 2013

The Zintl‐phase Sr3AlSb3, which contains relatively earth‐abundant and nontoxic elements, has many of the features that are necessary for good thermoelectric performance. The structure of Sr3AlSb3 is characterized by isolated anionic units formed from pairs of edge‐sharing tetrahedra. Its structure is distinct from previously studied chain‐forming structures, Ca3AlSb3 and Sr3GaSb3, both of which are known to be good thermoelectric materials. DFT predicts a relatively large band gap in Sr3AlSb3 (Eg≈1 eV) and a heavier band mass than that found in other chain‐forming A3MSb3 phases (A=Sr, Ca; M=Al, Ga). High‐temperature transport measurements reveal both high resistivity and high Seebeck coefficients in Sr3AlSb3, which is consistent with the large calculated band gap. The thermal conductivity of Sr3AlSb3 is found to be extremely low (≈ 0.55 W mK−1 at 1000 K) due to the large, complex unit cell (56 atoms per primitive cell). Although the figure of merit (zT) has not been optimized in the current study, a single parabolic band model suggests that, when successfully doped, zT≈ 0.3 may be obtained at 600 K; this makes Sr3AlSb3 promising for waste‐heat recovery applications. Doping with Zn2+ on the Al3+ site has been attempted, but does not lead to the expected increase in carrier concentration.
Electrochemical Properties of Yolk–Shell‐Structured CuO–Fe2O3 Powders with Various Cu/Fe Molar Ratios Prepared by One‐Pot Spray Pyrolysis
Authors: Yang Kwang Min , Hong Young Jun , Kang Yun Chan
Published: October 2013

Several yolk–shell‐structured CuO–Fe2O3 powders with various Cu/Fe molar ratios have been successfully prepared under equivalent reaction conditions using a one‐pot spray pyrolysis process. The Cu and Fe components are uniformly distributed throughout the powders, irrespective of composition. The Brunauer–Emmett–Teller surface areas of the yolk–shell CuO–Fe2O3 systems increased from 5 to 16 m2 g−1 if the Cu/Fe molar ratios are decreased from 3:1 to 1:3. The initial discharge and charge capacities of the yolk–shell CuO–Fe2O3 system (Cu/Fe=1:2), showing maximum values at a constant current density of 1000 mA g−1, are 1436 and 1012 mA h g−1, respectively. After 130 cycles, the discharge capacities of the yolk–shell CuO–Fe2O3 powders with Cu/Fe molar ratios of 1:3, 1:2, 1:1, 2:1, and 3:1 are 1159, 1151, 755, 655, and 651 mA h g−1, respectively. The discharge capacities of the yolk–shell and dense powder samples after 50 cycles, when subjected to a series of current density increases from 500 to 5000 mA g−1, are 735 and 495 mA h g−1, respectively.
Measurements of SiH4/H2 VHF Plasma Parameters with Heated Langmuir Probe
Authors: Yamane T. , Nakao S. , Takeuchi Y. , Muta H. , Ichiki R. , Uchino K. , Kawai Y.
Published: October 2013

The parameters of a SiH4/H2 VHF plasma were measured as a function of silane gas concentration with a heated Langmuir probe. It was found that when the sailane gas concentration is increased, the nagative ion density increases. Here the negative ion density was estimated from the reduction of the electron saturation current. In addition, the dependence of the wall potential on the silane gas concentration agreed with the theoretical values derived from the Bohm sheath equation including negative ions. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Image thresholding techniques for localization of sub‐resolution fluorescent biomarkers
Authors: Ghaye Julien , Kamat Madhura Avinash , Corbino‐Giunta Linda , Silacci Paolo , Vergères Guy , De Micheli Giovanni , Carrara Sandro
Published: October 2013

Abstracts

In this article, we explore adaptive global and local segmentation techniques for a lab‐on‐chip nutrition monitoring system (NutriChip). The experimental setup consists of Caco‐2 intestinal cells that can be artificially stimulated to trigger an immune response. The eventual response is optically monitored using immunofluoresence techniques targeting toll‐like receptor 2 (TLR2). Two problems of interest need to be addressed by means of image processing. First, a new cell sample must be properly classified as stimulated or not. Second, the location of the stained TLR2 must be recovered in case the sample has been stimulated. The algorithmic approach to solving these problems is based on the ability of a segmentation technique to properly segment fluorescent spots. The sample classification is based on the amount and intensity of the segmented pixels, while the various segmenting blobs provide an approximate localization of TLR2. A novel local thresholding algorithm and three well‐known spot segmentation techniques are compared in this study. Quantitative assessment of these techniques based on real and synthesized data demonstrates the improved segmentation capabilities of the proposed algorithm. © 2013 International Society for Advancement of Cytometry
Efficient secondary access with intelligent spectrum sensing in cognitive radio networks
Authors: Dai Zeyang , Liu Jian , Sun Zhi , Long Keping
Published: October 2013

In cognitive radio networks, cooperative sensing can significantly improve the performance in detection of a primary user via secondary users (SUs) sharing their detection results. However, a large number of cooperative SUs may induce great sensing delay, which degrades the performance of secondary transmissions. In this paper, we jointly consider cooperative sensing and cognitive transmission in cognitive radio networks, aiming to achieve efficient secondary access with low sensing overhead under both the sensing time and reporting power limitations, where primary users are guaranteed to be sufficiently protected. We first propose an adaptive sensing scheme to lower the detection time while not degrading the detection probability. Then, based on the proposed adaptive sensing scheme, an efficient cognitive transmission protocol is well designed, which improves the throughput of secondary transmissions while ensuring the QoS of primary transmissions. We analyze the performance for the proposed secondary access framework in terms of misdetection probability, average detection time and normalized secondary throughput, respectively, and derive their closed‐form expressions over Rayleigh fading channels with considering the reporting errors accordingly. We also study the problems of optimizing the number of cooperative SUs to minimize the misdetection probability and average detection time, and maximize the normalized secondary throughput for proposed framework. Simulation results reveal that the proposed framework outperforms the traditional case significantly. Copyright © 2013 John Wiley & Sons, Ltd.
Cooperative quadrature physical layer network coding in wireless relay networks
Authors: Yang Hongjuan , Chong Peter H. J. , Meng Weixiao , Li Bo , Guan Yong Liang
Published: October 2013

This paper proposes a cooperative quadrature physical layer network coding (CQPNC) scheme for a dual‐hop cooperative relay network, which consists of two source nodes, one relay node and one destination node. All nodes in the network have one antenna, and the two source nodes transmit their signals modulated with quadrature carriers. In this paper, a cooperative quadrature physical layer network coded decode‐and‐forward (DF) relay protocol (CQPNC‐DF) is proposed to transmit the composite information from the two source nodes via the relay node to the destination node simultaneously to reduce the number of time slots required for a transmission. The proposed CQPNC‐DF relay protocol is compared with time‐division multiple‐access amplify‐and‐forward (TDMA‐AF), TDMA‐DF, cooperative network coded DF (CNC‐DF) and cooperative analog network coded AF (CANC‐AF) relay protocols to demonstrate its effectiveness in terms of bit error rate (BER) and system throughput under different propagation conditions. The simulation results reveal that the proposed CQPNC‐DF relay protocol can significantly improve the network performance. Compared with two TDMA schemes and CNC‐DF, the proposal can provide up to 100% and 50% throughput gains, respectively. Moreover, no matter what the scene, the proposed scheme always has the lowest BER in the low SNR region. Copyright © 2013 John Wiley & Sons, Ltd.
Time domain leakage in DFT‐based channel estimation for OFDM systems with guard bands
Authors: Fahmy Y. A. , Hafez H. , Khairy M. M.
Published: October 2013

In this paper, a mathematical analysis of the time domain leakage problem in the discrete Fourier transform (DFT) based channel estimation technique is presented. The time domain leakage is because of the absence of pilots in the guard band. Several solutions to this problem were previously proposed based on reducing the leakage in the frequency domain. These solutions significantly increase the receiver complexity. In this paper, the root cause of the leakage problem is linked to the time domain and a modification is proposed carrying slight additional complexity over the conventional DFT‐based estimator. Performance evaluation is assessed in terms of the bit error rate and the mean square error. The proposed modification significantly decreases the error floor of the conventional DFT‐based channel estimation technique. In addition, its performance is comparable to other more complex techniques recently proposed.Copyright © 2013 John Wiley & Sons, Ltd.
On the Reactivity of Platina‐β‐diketone and Acetylplatinum(II) Complexes toward 2‐(Diphenylphosphanyl)benzaldehyde and Its Dioxolane Derivative
Authors: Kluge Tim , Mendicute‐Fierro Claudio , Bette Martin , Rodríguez‐Diéguez Antonio , Garralda Maria A. , Steinborn Dirk
Published: October 2013

The dinuclear platina‐β‐diketone [Pt2{(COMe)2H}2(μ‐Cl)2] (1) reacts with four and two equivalents of 2‐[2‐(diphenylphosphanyl)phenyl]‐1,3‐dioxolane (L1) to yield [Pt(COMe)Cl(PPh2{o‐C6H4CH(O2C2H4)}‐κP)2] (3) and [Pt(COMe)Cl(PPh2{o‐C6H4CH(O2C2H4)}‐κP,κO)] (4), respectively. The weak Pt–O bond in 4 can be easily broken up by stronger donors. Thus, complex 4 reacts with PPh3 to yield [Pt(COMe)Cl(PPh3)(PPh2{o‐C6H4CH(O2C2H4)}‐κP)] (5) and [Pt(COMe)Cl(PPh3)2] (6) as well as with L1 to yield 3. Diacetylbis(amine)platinum(II) complexes cis‐[Pt(COMe)2(NH2R)2] (R = Bn, 2a; R = Et, 2b; Bn = benzyl) react with L1 with the substitution of one amine ligand to yield [Pt(COMe)2(NH2R)(PPh2{o‐C6H4CH(O2C2H4)}‐κP)] (R = Bn, 7a; R = Et, 7b). The unprotected 2‐(diphenylphosphanyl)benzaldehyde (L2) reacts with the platina‐β‐diketone 1 by oxidative C–H addition followed by reductive elimination of acetaldehyde to form [PtCl{PPh2(o‐C6H4CO)‐κP,κC}{PPh2(o‐C6H4CHO)‐κP}] (8). On the other hand, the reactions of diacetylbis(amine)platinum(II) complexes 2a/b and L2 proceeded with Schiff base formation and, thus, yielded complexes bearing hemiaminal–phosphane ligands, [Pt(COMe)2(PPh2{o‐C6H4CH(OH)(NHR)}‐κP,κN)] (R = Bn, 9a; R = Et, 9b), and imine–phosphane ligands, [Pt(COMe)2{PPh2(o‐C6H4CH=NR)‐κP,κN}] (R = Bn, 10a; R = Et, 10b). The identities of all platinum complexes were unambiguously proved by microanalyses, high‐resolution mass spectrometric investigations, NMR (1H, 13C, 31P, 195Pt) and IR spectroscopy, and single‐crystal X‐ray diffraction analyses (for 4, 9a). The differences in the reactivity of the aldehyde–phosphane L2 and its acetal‐protected derivative L1 are discussed.
Syntheses, Photoluminescence, and Electroluminescence of Iridium(III) Complexes with Fluorinated 2‐Phenylpyridine as Main Ligands and Tertraphenylimidodiphosphinate as Ancillary Ligand
Authors: Wang Cheng‐Cheng , Jing Yi‐Ming , Li Tian‐Yi , Xu Qiu‐Lei , Zhang Song , Li Wei‐Nan , Zheng You‐Xuan , Zuo Jing‐Lin , You Xiao‐Zeng , Wang Xiu‐Qiang
Published: October 2013

Three green‐emitting heteroleptic iridium complexes with 2‐(4,5,6‐trifluorophenyl)pyridine, 2‐(3,4,6‐trifluorophenyl)pyridine, and 2‐(3,4,5‐trifluorophenyl)pyridine as main ligands and tetraphenylimidodiphosphinate (tpip) as the ancillary ligand were synthesized and characterized. The positions of the three fluorine atoms on the phenyl ring affect the emission properties of the complexes, and the application of Htpip as the ancillary ligand improves the electron mobility of the complexes to make it comparable to that of the popular electron transport material tris(8‐hydroxyquinolinato)aluminium (Alq3) under the same electric fields. The organic light‐emitting diodes (OLEDs) based on the above phosphorescent emitters {indium tin oxide (ITO)/1,1‐bis[4‐(di‐p‐tolyl‐amino)phenyl]cyclohexane (TAPC), 30 nm/Ir complex (x wt.‐%)/N,N′‐dicarbazolyl‐3,5‐benzene (mCP), 15 nm/1,3,5‐tri(1‐phenyl‐1H‐benzo[d]imidazol‐2‐yl)phenyl (TPBi), 45 nm/LiF (1 nm)/Al (100 nm)} exhibited good performances. The device doped with bis[2‐(3,4,6‐trifluorophenyl)pyridine](tetraphenylimidodiphosphinato)iridium [Ir(F3,4,6ppy)2(tpip)] (8 wt.‐%) showed superior performance with a peak current efficiency (ηc) of 66.36 cd A–1 and a peak external quantum efficiency (ηext, EQE) of 25.7 % at 5.8 V, a maximum power efficiency (ηp) of 48.20 lm W–1 at 4.4 V, and a maximum luminance (Lmax) of 47627 cd m–2 at 12.6 V. Notably, the electroluminescence (EL) efficiency roll‐off effects at relatively high current density in all devices are very mild, which helps them to obtain high efficiency at brightness. The results suggest that the three complexes, [Ir(F3,4,6ppy)2(tpip)] especially, would have potential applications in OLEDs.
Heterobimetallic Metal–Amidinate Complexes by Stepwise Metalation of Methanetrisamidines
Authors: Gutschank Benjamin , Bayram Melike , Schulz Stephan , Bläser Dieter , Wölper Christoph
Published: October 2013

The acidity of the four N–H groups in methanetrisamidine 1c differs significantly, thereby allowing stepwise metalation by metal organic compounds such as ZnMe2, AlMe3, and GaMe3. Dinuclear complexes 3a–c were formed under kinetic control in the reactions of 1c with 2 equiv. of the metal organic compounds at low temperatures, whereas prolonged reaction times at elevated temperature (100 °C) with 4 equiv. of ZnMe2, AlMe3, and GaMe3 yielded the corresponding tetranuclear complexes 4a–c. The different acidity of the four N–H groups also allowed the stepwise metalation of 1c by two different metal organic complexes with the formation of the heterobimetallic complexes 5a and 5b. In addition, transmetalation by Zn/Al exchange was observed in the reaction of 3c with AlMe3, yielding the corresponding dinuclear aluminium complex 3a. The complexes were characterized by NMR and IR spectroscopy and single‐crystal X‐ray diffraction (3a, 4b, 5a).
Syntheses and Solid‐State Structures of Bis(dialkylstibanyl)sulfanes and ‐telluranes
Authors: Heimann Stefan , Schulz Stephan , Bläser Dieter , Wölper Christoph
Published: October 2013

Invited for the cover of this issue is the group of Stephan Schulz at the University of Duisburg‐Essen. The cover image illustrates the in situ crystallization technique, which is the thermally induced transformation of polycrystalline (diethylstibanyl)tellurane, (Et2Sb)2Te, into a single‐crystalline sample by use of an IR laser, which allows melting and recrystallization of the sample in a N2 cooling steam directly on the diffractometer. The technique provides useful structural information for small molecules and allows a detailed investigation of their intermolecular interactions in the solid state.
Synthesis of Oxazole Analogs of Streptolidine Lactam
Authors: Rynearson Kevin D. , Dutta Sanjay , Tran Kiet , Dibrov Sergey M. , Hermann Thomas
Published: October 2013

The streptolidine lactam is an amino acid constituent of streptothricin antibiotics, which inhibit protein synthesis by targeting the bacterial ribosome but suffer from toxicity as a result of the basicity of the aminoimidazole scaffold in the natural products. On the basis of the streptolidine structure, we designed and synthesized oxazole analogs with six‐ and seven‐membered lactam rings as building blocks for RNA‐targeted ligands. These analogs benefit from a dense network of hydrogen‐bond donors and acceptors within a rigid nonplanar heterocyclic system that has attenuated basicity.