bluuebunny/crossref_metadata_2025 huggingface dataset:
New progress and prospects of mechanical exfoliation technology of two-dimensional materials
Authors: Huang Xin-Yu , Han Xu , Chen Hui , Wu Xu , Liu Li-Wei , Ji Wei , Wang Ye-Liang , Huang Yuan ,   Advanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing 100081, China,   MIIT Key Laboratory for Low-Dimensional Quantum Structure and Devices, School of Integrated Circuits and Electronics, Beijing Institute of Technology, Beijing 100081, China,   School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China,   Department of Physics, Renmin University of China, Beijing 100872, China
Published: March 2022

Since the monolayer graphene was first obtained in the year of 2004, mechanical exfoliation technique has been widely used to prepare various two-dimensional materials such as transition metal dichalcogenides and black phosphorus. Among a variety of preparation techniques of two-dimensional materials, mechanical exfoliation technique shows advantages in its simplicity and universality. More importantly, the exfoliated two-dimensional samples are the ideal ones for many novel phenomena. This paper introduces the background of mechanical exfoliation technique and summarizes the problems of conventional mechanical exfoliation technique in the development of two-dimensional materials. In order to solve the problems of low efficiency and small sample size of conventional mechanical exfoliation technique, some modified mechanical exfoliation techniques have been developed, such as oxygen-plasma-assisted exfoliation method and gold-film-assisted exfoliation method. As a commonly used “top-down” preparation method, the new exfoliation technology is still full of vitality in basic research and application of two-dimensional materials. In the future, larger size and higher quality will be the development direction of exfoliation technology.
Optical echo memory based on photonic crystal cavities
Authors: Xing Xue-Yan , Li Xia-Xia , Chen Yu-Hui , Zhang Xiang-Dong ,   Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education, School of Physics, Beijing Institute of Technology, Beijing 100081, China
Published: March 2022

Like internet, connecting quantum computers together to build a full quantum network will enhance the ability to process quantum information. On-chip quantum memories can possess the essential functionalities in building a quantum network, including synchronizing a large number of quantum computers and implementing long-distance quantum communication. However, owning mainly to the constraints imposed by the micro-photonic structures themselves, on-chip quantum memories cannot satisfy the requirement for constructing the full quantum network for the incompatibility of their memory property and integration property. We here propose to build an on-chip quantum memory by using spatial-phase-mismatching effect in photonic crystal cavities. In this scenario, not only is the large orbital angular momentum of photonic crystal cavities utilized to realize photon-echo type memory, but also the light-matter enhancement of a photonic cavity is used to achieve a high-efficiency quantum storage.
Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure
Authors: Baldwin Austin T , Kim Juliana H , Seo Hyemin , Wallingford John B
Published: March 2022

Failures of neural tube closure are common and serious birth defects, yet we have a poor understanding of the interaction of genetics and cell biology during neural tube closure. Additionally, mutations that cause neural tube defects (NTDs) tend to affect anterior or posterior regions of the neural tube but rarely both, indicating a regional specificity to NTD genetics. To better understand the regional specificity of cell behaviors during neural tube closure, we analyzed the dynamic localization of actin and N-cadherin via high-resolution tissue-level time-lapse microscopy during Xenopus neural tube closure. To investigate the regionality of gene function, we generated mosaic mutations in shroom3, a key regulator or neural tube closure. This new analytical approach elucidates several differences between cell behaviors during cranial/anterior and spinal/posterior neural tube closure, provides mechanistic insight into the function of shroom3, and demonstrates the ability of tissue-level imaging and analysis to generate cell biological mechanistic insights into neural tube closure.
Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host
Authors: D'Angelo Francesca , Fernández-Fueyo Elena , Garcia Pierre Simon , Shomar Helena , Pelosse Martin , Manuel Rita Rebelo , Büke Ferhat , Liu Siyi , van den Broek Niels , Duraffourg Nicolas , de Ram Carol , Pabst Martin , Bouveret Emmanuelle , Gribaldo Simonetta , Py Béatrice , Ollagnier de Choudens Sandrine , Barras Frédéric , Bokinsky Gregory
Published: March 2022

Iron-sulfur (Fe-S) clusters are ancient and ubiquitous protein cofactors and play irreplaceable roles in many metabolic and regulatory processes. Fe-S clusters are built and distributed to Fe-S enzymes by dedicated protein networks. The core components of these networks are widely conserved and highly versatile. However, Fe-S proteins and enzymes are often inactive outside their native host species. We sought to systematically investigate the compatibility of Fe-S networks with non-native Fe-S enzymes. By using collections of Fe-S enzyme orthologs representative of the entire range of prokaryotic diversity, we uncovered a striking correlation between phylogenetic distance and probability of functional expression. Moreover, coexpression of a heterologous Fe-S biogenesis pathway increases the phylogenetic range of orthologs that can be supported by the foreign host. We also find that Fe-S enzymes that require specific electron carrier proteins are rarely functionally expressed unless their taxon-specific reducing partners are identified and co-expressed. We demonstrate how these principles can be applied to improve the activity of a radical S-adenosyl methionine(rSAM) enzyme from a Streptomyces antibiotic biosynthesis pathway in Escherichia coli. Our results clarify how oxygen sensitivity and incompatibilities with foreign Fe-S and electron transfer networks each impede heterologous activity. In particular, identifying compatible electron transfer proteins and heterologous Fe-S biogenesis pathways may prove essential for engineering functional Fe-S enzyme-dependent pathways.
Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors
Authors: Ruiz Alexis , Benucci Sofia , Duthaler Urs , Bachmann Christoph , Franchini Martina , Noreen Faiza , Pietrangelo Laura , Protasi Feliciano , Treves Susan , Zorzato Francesco
Published: March 2022

To date there are no therapies for patients with congenital myopathies, muscle disorders causing poor quality of life of affected individuals. In approximately 30% of the cases, patients with congenital myopathies carry either dominant or recessive mutations in the ryanodine receptor 1 (RYR1) gene; recessive RYR1 mutations are accompanied by reduction of RyR1 expression and content in skeletal muscles and are associated with fiber hypotrophy and muscle weakness. Importantly, muscles of patients with recessive RYR1 mutations exhibit increased content of class II histone deacetylases and of DNA genomic methylation. We recently created a mouse model knocked-in for the p.Q1970fsX16+ p.A4329D RyR1 mutations, which are isogenic to those carried by a severely affected child suffering from a recessive form of RyR1-related multi-mini core disease. The phenotype of the RyR1 mutant mice recapitulates many aspects of the clinical picture of patients carrying recessive RYR1 mutations. We treated the compound heterozygous mice with a combination of two drugs targeting DNA methylases and class II histone deacetylases. Here, we show that treatment of the mutant mice with drugs targeting epigenetic enzymes improves muscle strength, RyR1 protein content, and muscle ultrastructure. This study provides proof of concept for the pharmacological treatment of patients with congenital myopathies linked to recessive RYR1 mutations.
Patient’s Self-Decision and Death in Court Decisions and the Law of Decision of Life-Sustaining Medical Care
Authors: Na Joo-Young , Park Jong-Tae
Published: March 2022

The South Korean Supreme Court decision (2009Da17471), May 21, 2009, on removing life-sustaining medical care from persistent vegetative patients gave consent to death with dignity and initiated a lively debate in South Korea. The legal grounds for this decision were based on dignity, worth, and the right to pursue happiness regulated in Article 10 of the Constitution, The Death with Dignity Act was legislated as a law for life-sustaining medical care through debate and agreement on February 3, 2016, and has since been revised four times. However, there are some issues to discuss with this Act. First, the definition of the process of dying is unclear because the determining point of the dying process is different from the status of the attachment or detachment of an artificial ventilator. Second, the purpose of this law is the protection of dignity, worth, and the right to pursue happiness. As nutrition, fluid, and oxygen must be continuously supplied, even if the artificial ventilator is removed, is it reasonable to suggest that supplying these continuously achieves Article 10 of the Constitution? Third, if the withdrawal of life-sustaining medical care is possible or permitted without the patient’s approval, what is the legal value of advance directives? Fourth, it is whether death with dignity could be extended to the euthanasia. Conclusively, it may be necessary to partially revise the law for life-sustaining medical care through further debate and agreement.
Sudden Cardiac Death from Coronary Arteriosclerosis and Coronary Artery Aneurysm in Childhood: An Autopsy Case
Authors: Lee Ho , Noh Sang Jae
Published: March 2022

Coronary artery disease in childhood is rare. However, coronary arteriosclerosis and coronary artery aneurysm may occur in childhood as congenital malformations, or as complications of vasculitis, other connective tissue disorders, and infections. Coronary arteriosclerosis and coronary artery aneurysm may manifest in varied ways, including silent ischemia, myocardial infarction and sudden cardiac death. In this report, we present a rare case of sudden death in 5-year-old child. Autopsy examination showed coronary arteriosclerosis and coronary artery aneurysm with myocardial fibrosis of the septal wall. Pathologic examination showed near total occlusion of the left anterior descending branch of the coronary artery and the aneurysm, with fibrosis and calcification of the right coronary artery.
Back pain and body posture of non-professional Brazilian Jiu-Jitsu practitioners
Authors: Sędek Katarzyna , Truszczyńska-Baszak Aleksandra , Cygańska Anna Katarzyna , Drzał-Grabiec Justyna
Published: March 2022

Background

The aim of the study was to assess the prevalence of back pain in non-professional Brazilian Jiu-Jitsu practitioners (NP-BJJ practitioners), and to assess the relationship between their back pain and postural disorders.

Methods

The study involved 61 subjects (age: 30.7 ± 4.9 years old; body mass: 79.4 ± 12.9 kg; body height: 179.6 ± 8.4 cm; 8 woman and 53 man), 31 who trained Brazilian Jiu-Jitsu (BJJ) and 30 subjects who had never trained any combat sport. The mean time of training BJJ in the study population was 3.9 ± 4.1 years. Postural assessments were conducted with the use of the photogrammetric method. The assessment of back pain and injuries was conducted with the Oswestry Disability Index (ODI) and with our proprietary questionnaire.

Results

Among both populations, 37 subjects reported back pain. There were no differences in back pain location between the two groups or in functional state on the ODI. Significant differences between the groups in the values of the postural parameters (spinal height, length of kyphosis, length of lordosis, pelvis inclination angle) were observed. Statistically significant differences between the NP-BJJ practitioners with and without back pain in the length of the thoracic kyphosis and the differences in the height of the waist triangles were found.

Conclusions

Both in the study population and in the control group the spinal pain was minimal or moderate on the ODI. BJJ practitioners who reported back pain had characteristic postural changes in some of the analysed postural parameters in comparison to BJJ practitioners who did not report back pain.
Tendencias y efectos socioambientales del desarrollo inmobiliario turístico en zonas costeras de Sudamérica. El caso de Región Este, Uruguay
Authors: Gadino Isabel , Sciandro José , Taveira Germán , Goldberg Nathalie
Published: March 2022

La costa de Región Este, Uruguay, tiene un desarrollo histórico vinculado al turismo residencial. En las últimas décadas aprobó nuevos instrumentos de ordenamiento territorial. Simultáneamente, el avance inmobiliario, en particular el destinado al turismo neoexclusivo (tne), se extiende y acapara espacios naturales. Este trabajo analiza resultados locales del tne, comparando la apropiación de servicios ecosistémicos y las dinámicas socioterritoriales, con el modelo de costa promovido desde el ordenamiento territorial y la legislación vinculada. Se contrasta información georreferenciada con análisis cuantitativos y cualitativos de normativas, solicitudes de permisos ambientales, solicitudes de excepciones al ordenamiento territorial e información empleada para la oferta de los emprendimientos en el mercado. Se observa una clara relación entre sitios ecosistémicos clave y los nuevos emprendimientos, grandes discordancias en las informaciones emitidas por los promotores, así como un claro sesgo de la normativa tendiente al uso exclusivo del espacio en aras de su conservación.
Exportación de la contaminación en Chile: Análisis de procedimientos sancionatorios de la Superintendencia de Medio Ambiente, 2013-2019
Authors: Bergamini Kay , Dextre Rosa-María
Published: March 2022

El modelo económico basado en la extracción y exportación de recursos naturales a países procesadores de materias primas, y la influencia de las grandes potencias o países desarrollados en esa condición, han provocado deterioro ambiental. En esta investigación se analiza los datos de los procedimientos sancionatorios impuestos por la Superintendencia del Medio Ambiente de Chile entre los años 2013 y 2019 a los titulares de los proyectos de inversión que incumplieron con la normativa ambiental vigente. Se comprueba que los rubros con mayor formulación de cargos corresponden a actividades de exportación (minería, agropecuario, instalaciones fabriles, y pesca y acuicultura), cuyas multas por incumplimientos ambientales ascienden a casi 411.000.000 usd y son liderados, después de Chile, por capitales de inversión extranjera. Se argumenta que estas compañías de países con mejores estándares ambientales no aplican las mismas condiciones de operación en Chile. Esto permite mostrar carencias en la implementación de políticas estatales y empresariales relacionadas con el discurso del desarrollo sostenible del país.
Uma discussão sobre a hipótese da transferência de capital no Brasil: desafios para a financeirização urbana
Authors: Souza Marcos
Published: March 2022

La hipótesis de la transferencia de capital, elaborada por David Harvey, es una contribución influyente en los estudios urbanos, aunque su validez empírica no ha sido examinada en el contexto brasileño. Para una discusión de sus efectos se realiza un análisis de la relación entre el boom inmobiliario (2007-2013) y la crisis económica (2015) que enfrenta el país. Después de una revisión de la literatura se analiza la especificidad brasileña con respecto a la posibilidad de transferencia geográfica y sectorial de capital, utilizando datos de inversión extranjera directa e inversión en maquinaria y equipo y en la construcción de edificios. Se argumenta que las posibilidades de transferencia de capital para el ambiente construido en una economía subdesarrollada dependen de la forma específica de actuación del Estado (directa e indirectamente), de las instituciones mediadoras y de la complementariedad entre inversión pública y privada.
Los desplazamientos sociales en los programas de renovación urbana del Centro Histórico de Lima (1996-2016)
Authors: Lopez Sharo , Paraizo Rodrigo
Published: March 2022

Las condiciones de precariedad de las viviendas tugurizadas y la pobreza urbana de los residentes del Centro Histórico de Lima se han ahondado debido a las reformas estatales neoliberales implementadas en la década de 1990, entre las cuales se encuentran los programas de renovación urbana con inversión privada, bajo estos programas el Estado otorgó al mercado la responsabilidad de solucionar el acceso a la vivienda. Se presenta tres casos de estudio que evidencian que los programas de renovación urbana ejecutados por el gobierno nacional y local no han logrado solucionar el problema de tugurización, y se pone en evidencia que estos han generado diversos tipos de desplazamientos sociales directos e indirectos, en cadena, antes, durante y después de su ejecución. Asimismo, se concluye que los tres programas estudiados fueron puntuales pues solo abarcaron determinados inmuebles, excluyentes y exclusivos porque los beneficiados tenían que cumplir un conjunto requerimientos de la banca.
Gobernanza del transporte en áreas metropolitanas: revisión crítica y análisis para Santiago de Chile
Authors: Larraín-Videla Clemente , Muñoz Juan-Carlos , Briones Julio
Published: March 2022

Para abordar los desafíos de movilidad en las áreas metropolitanas, se ha cuestionado la institucionalidad política y territorial desde donde se planifica, invierte y gestiona el transporte y desarrollo urbano. En este trabajo se realiza una evaluación y revisión crítica del efecto de la gobernanza en las políticas de transporte en áreas metropolitanas, considerando los grados de integración entre las agencias públicas y la distribución de poder y competencias en los diferentes niveles de gobierno. Luego, se propone una metodología que permite caracterizar una gobernanza de transporte urbano. Aplicando esta metodología a Santiago de Chile, se observa: i) una centralización del poder y competencias; ii) dispersión y especialización de funciones; y iii) fragmentación del territorio. El marco de análisis propuesto puede ser útil para descomponer y comparar los diseños institucionales metropolitanos y reconocer reformas que mejoren el desempeño de las políticas de transporte.
Study of Morphometry of Clavicle in East Indian Population
Authors: Kundu Banani , Saha Pallab Kumar , Mukherjee Parijat
Published: March 2022

Introduction: The clavicle is a subcutaneous bone most frequently fractured at the junction of medial 2/3rd and lateral 1/3rd of its shaft. The knowledge about the morphometry of clavicle is important for surgeons as well as orthopaedic surgeons. Aim: The aim of this study is to measure the variation of length, medial and lateral angle in east Indian population. Materials and Methods: In this observational cross-sectional study, 54 dry adult clavicle (25 males, 29 females) were collected from the first year medical students of various colleges of West Bengal (east India). The length, medial and lateral angles were measured. The data obtained was tabulated in Microsoft Excel sheet and then transferred to IBM Statistical Package for the Social Sciences (SPSS) version 23. The data was analysed using Independent Sample t-test assuming unequal variances, taking p<0.05 as statistically significant. Results: The average mean length of left sided clavicle was slightly more in both male and female than the right side. But this difference was statistically nonsignificant as p-value was 0.768 (male) and 0.74 (female). In male, the average lateral angle of left side was more than the right side but not so in case of female where the right side was more than the left side. This difference was statistically significant in case of both male (p-value=0.0008), and female (p-value=0.0001). In case of medial angle, it was more in left side in both males and females. The difference was also significant in both males (p-value 0.0001) and females (p-value=0.00001). Conclusion: The present study revealed that the average length of clavicle in case of males are more in right and left side than females. The lateral angle is more for females on right side and more for males on the left side. The medial angle is more for females on both right and left side as compared to males.
Prevalence and Distribution of Pterion in Adult Dry Human Skull and its Clinical Importance
Authors: Agrawal Nidhi , Punase Vandana , Gour Kranti Kumar
Published: March 2022

Introduction: The pterion is a topographic point on the lateral aspect of the skull, where frontal, sphenoid, parietal and temporal bones meet. It lies in the anterior part of floor of the temporal fossa about 4 cm above the zygomatic arch and 3.5 cm behind the fronto-zygomatic suture. Aim: To determine the prevalence of type and position of the pterion using the standard cranial anatomical points. Materials and Methods: The present cross-sectional study was conducted from July 2020 to September 2020 in NSCB Medical college Jabalpur (M.P.). One hundred and eighty dry human skull obtained from Department of Anatomy. Sutural pattern of pterion were classified into sphenoparietal, frontotemporal, epipteric or stellate type. Position of pterion was also determined in relation to three specific bony landmarks. All parameters were evaluated bilaterally, observations tabulated and analysed using SPSS software version 23. results: In present study, it was found that 84% (n=180) skull posses sphenoparietal type of pterion bilaterally, then epipteric type (7.73%) followed by frontotemporal (6.61%) and the least variety was stellate type (1.83%). The mean distance from upper end of zygomatic arch up to centre of pterion on right side was 35.12±4.1 mm and on the left side was 36.26±3.88 mm. The distance from posterolateral margin of frontozygomatic suture up to centre of pterion on right side was 28.84±5.80 mm and on the left side was 30.10±4.79 mm. conclusion: The study concluded that in present study, sphenoparietal type of pterion was most common bilaterally and stellate type was least common. The detailed data about the location of the pterion serves as a benchmark for neurosurgeons to localise the correct position for burr hole during all invasive surgeries
Dopamine’s Role in Psychopathology and Biochemistry of Brain
Authors: Pournamdar Pouya , Azadi Pooneh , Seyyed Valilou Mir Mahmoud , Oliaei Niloufar
Published: March 2022

Dopamine (dihydroxyphenethylamine) is an organic compound from the family of Catecholamines and Phenylamines and plays an important role in the brain functioning. Dopamine is synthesized by precursors in the kidneys and brain. Dopamine is among the essential neurotransmitters in the brain, which is especially involved in pleasure and reward circuits, motivation, motor controls, functional ability, perception, sexual satisfaction, inhibition of milk secretion (lactation prevention), and nausea. This research aims to study the role of dopamine in psychopathology and biochemistry of the brain, through the document-analytical method. Review, evaluation and analysis of the previous articles imply that dopamine plays an important role in psychopathology and biochemistry of the brain.  In conclusion, it is recommended for mentioned items to be empirically researched due to importance in basic and clinical research.
Quantifying Senior High School Students’ Satisfaction in the Implemented Modular Distance Learning
Authors: Coros Joenel D.
Published: March 2022

Aims: The absence of data that could inform education stakeholders on what demographic variables play a significant role in the implementation of modular distance learning (MDL) and on areas of it, so that programs and innovations may be initiated to improve its implementation, encouraged the conduct of the study. The study aimed to assess the level of satisfaction in MDL of Senior High School Students’ as a whole, and in areas of Content of Self-Learning Modules, Teacher-Support, Parental Support, and Assessment and Feedbacking. It also seeks to determine in which demographic variables their level of satisfaction exist and whether their satisfaction has a correlation with parents' highest educational attainment or none.

Methodology: This study utilized descriptive-comparative and descriptive-correlational design.  It was participated by 346 Senior High School Students drawn through multi-stage sampling. Generated data were analyzed using mean, standard deviation, Mann-Whitney U test, and Spearman rho rank correlation.

Results: Results have shown that senior high school students are generally satisfied with the implementation of modular distance learning. Inferential results revealed that a significant difference exists between grade levels (P=.013). There was no significant difference when students were grouped according to track (P=.34), and availability of gadgets for academic use (P=.12). Interestingly, findings show that parents’ highest educational attainment influenced students' level of satisfaction (P=.000) in modular distance learning.

Conclusion: The study concluded that instructional and academic support provided by teachers and parents of Senior High School students remains vital, regardless of their grade level. Furthermore, the experiences they have in the implementation of MDL, which lead to their satisfaction or non-satisfaction in its implementation may be associated with their parent's level of education.
The Effects of Poor Financial Condition to Needy Students of Private and Public Colleges of Mafinga Town Council, Iringa Tanzania
Authors: Abdallah Ahmed Ally , Msambila Amos Ansigary , Kapange Solomon
Published: March 2022

The study was conducted to find out the effects of poor financial condition to needy students of private and public colleges in Mafinga Town Council, Iringa Tanzania. The study used a cross-sectional study design based on mixed research approach. Primary data were collected using questionnaires, interviews and focus group discussions while secondary data were obtained through documentary reviews. Both purposive and random sampling techniques were used in selecting 30 respondents and 10 key informants for this study. The collected data were analysed using SPSS Version 20 to compute descriptive statistics such as percentages and frequencies while the results were presented in the form of tables and word text narration. The study found that inability to pay tuition fees, inability to meet basic needs (food, clothing, and accommodation), inability to buy books and supplies, inability to meet medical emergencies, college dropout, affect academic performance and taking much more time to stay in college and complete studies were found to be the major effects of poor financial conditions of needy students.

The study recommended that, the government and other agencies should establish entreprenuership education to the college students particularly to the needy students so as to develop business activities while learning without affect their academic performance, offering financial literacy from which students will have the ability to read, analyzed, manage and communicate personal financial conditions that affect their well-being, giving them learning materials and special scholarship to those who are willingly to learn with monitoring them during entire period of their learning.
Principal's Strategy in Developing Teacher Work Motivation
Authors: Wibowo Ari , Hasanah Enung
Published: March 2022

Aims: This study aims to explore the role of school principals in increasing teacher motivation to work professionally.

Study Design: This research is a qualitative research

Place and Duration of Study: Researchers conducted research at SD Aisyiyah Surya Ceria Karanganyar with the address Tegalasri RT. 5 RW. VI Bejen-Karanganyar, Central Java. This research was conducted around August 2021 to january 2022

Methodology: The researcher determines the research subject using purposive sampling technique, there are 3 participants including the principal, vice principal for curriculum affairs and 1 teacher. The criteria used to determine the selection of participants are based on structural positions in school and years of service. This study took data using interview and documentation techniques. The researcher checks the validity of the data using triangulation of sources and techniques and the researcher uses data analysis techniques with stages starting from reducing data, presenting data and drawing conclusions

Results: The results show that the principal's role in growing teacher motivation is by optimizing the supporting factors and minimizing obstacles in order to motivate teachers by implementing the strategy, namely; 1) giving awards 2) giving encouragement, direction and coaching, 3) giving authority to teachers to be active, innovative and creative, 4) giving appreciation to teacher achievements, 5) organizing outbound and picnics, 6) exemplary, 7) training, 8 ) fulfillment of facilities and infrastructure, and 9) comparative study.
Predictors of Bleeding Risks and Episodes in Heart Patients
Authors: Iqbal Muhammad Zahid , Kassab Yaman W. , Salih Ahmed Abdelrahman Gadelseed , Matias Winsthon Carpo , Kaur H. Jaasminerjiit , Iqbal Muhammad Shahid
Published: March 2022

Objective: The aim of this study was to determine predictors of bleeding risks and episodes in heart patients. This study also determined the effect of demographic characteristics and comorbidities on the bleeding episodes in heart patients.

Methods: A retrospective and observational study was done on a data collection form to obtain the required data. After adjusting confounders in logistic regression analysis model, (predicting likelihood of reporting bleeding risks and episodes), pure predictors of bleeding risks and episodes were determined. Descriptive and inferential statistics were applied using the Statistical Package for Social Sciences (SPSS) version 24.0. A p-value < 0.05 was considered statistically significant.

Results: Overall, 220 patients’ data on data collection forms were collected in the study. Out of the total studied patients, around 56 were on warfarin, 47 on dabigatran, 67 on rivaroxaban and 50 on apixaban. In addition, age and presence of comorbidity were observed as the pure and strong predictors of bleeding risks and episodes among the studied patients.

Conclusion: Age and presence of comorbidity were the pure and strong predictors of bleeding risks and episodes.
A Study Protocol for Evaluation of Clinical and Functional Outcomes of Forearm Bone Fractures Treated by Screw Intramedullary Nail
Authors: Shah Parth , Dhaniwala Nareshkumar
Published: March 2022

Background: The incidence of forearm fractures has increased rapidly over the past few years as a consequence of industrial accidents, interpersonal assaults, road traffic accidents, sports injuries, etc. The advantages of Closed or mini-open reduction using screw intramedullary nail and stable fixation include short duration and low-cost of surgery, 3 point fixation, and satisfactory union of the fracture. This study aims to assess the clinical, radiological, and functional outcomes of forearm bone fractures treated by Screw intramedullary nails.

Materials and Methods: This will be a Prospective Observational study conducted on 25 skeletally mature patients reporting to the dept. of Orthopedics, AVBRH, Wardha. Patients with fracture of radius and ulna together or single bone diaphyseal fracture in the forearm will be enrolled in the study. The findings will be analyzed using parameters proposed by Anderson et. al. scoring system for functional assessment and radiological union. Statistical analysis would be done to conclude the findings.

Expected Results: Significant clinical, radiological, and functional outcomes of forearm bone fractures treated by Screw intramedullary nail are expected.
Red Tea Mediated Synthesis and Characterisation of Copper Nanoparticles
Authors: Akshaya K. , Rajasekar Arvina , Rajeshkumar S.
Published: March 2022

Background: The synthesis of metallic nanoparticles is a lively area of education and, more importantly, “application research” in nanotechnology. A wide range of chemical and physical procedures might be used for synthesis of metallic nanoparticles. However, these methods are swarming with many problems including use of toxic solvents, generation of hazardous by-products, and high energy consumption. Accordingly, there's a vital need to develop environmentally benign procedures for synthesis of metallic nanoparticles. A promising approach to realize this objective is to take advantage of the wide array of biological resources in nature. Indeed, over the past several years, plants, algae, fungi, bacteria, and viruses have been used for production of low-cost, energy-efficient, and nontoxic metallic nanoparticles.

Aim: The aim of the current study was to synthesise and characterize the copper Nanoparticles mediated with red tea.

Materials and Methods: ​The green synthesis of the copper Nanoparticles was done using red tea. Morphological characters like the shape and size of the obtained copper nanoparticles were done by transmission electron microscopy (TEM).

Results: The results confirmed that the synthesised red tea mediated nanoparticles are eco-friendly, good and non toxic. TEM images showed that the copper nanoparticles were well dispersed, crystalline in nature. Copper nanoparticles are spherical in nature. The particles size was ranging from 40 to 90 nm, The TEM image shows that nanoparticles are not combined but are separated by equal interspace between the particles, which was confirmed by microscopy visualising under the higher resolution.

Conclusion: ​In this study, a simple, biological and low-cost approach was done for the preparation of copper nanoparticles using red tea extract. Thus the green synthesized copper nanoparticles can be subjected to the various other biological activities to test their biological efficiency and can be a pioneering step towards the shift to eco friendly medicine.
Evidence of Risk Factors Associated with Autosomal Dominant Polycystic Kidney Disease in Newly Diagnosed Adult Hypertensive Patients in NAUTH Nnewi, Nigeria
Authors: Ukibe Nkiruka R. , Kalu Anya O. , Emeje Isaac P. , Ukibe Solomon N. , Ukibe Gloria E. , Obiekezie Chigozie C.
Published: March 2022

Aims & objectives: Due to other chronic diseases that are associated with hypertension and kidney disease, little or no attention has been paid to the existence of polycystic kidney disease in Nigeria. The present study aimed at assessing the prevalence of some risk factors of ADPKD among hypertensive adult patients in NAUTH, Nnewi, Anambra State, Nigeria

Study design: A cross-sectional and prospective study

Place and Duration of Study: The study was carried out at Medical out-patient, cardiology and nephrology units of NAUTH Nnewi between February and June, 2019.

Methodology: A total of 160(80 newly diagnosed hypertensive and 80 normotensive subjects) aged between 25-75 years were randomly selected. Estimation of serum electrolytes, urea, creatinine, total calcium, eGFR and total protein, BMI and waist-hip ratio of the subjects were taken were done using standard laboratory methods.

Results: 12.5% of the hypertensive subjects have undergone dialysis, 7.5% had kidney transplant, 13.8% had hematuria, 20% had proteinuria, 27.5% had recurrent kidney infection, 15% had kidney stone, 43.8% experienced abdominal/side pain, 20% have had abdominal hernias and 46.3% had elevated urea/creatinine. Mean values of age, BMI and WHR were significantly higher in hypertensive than control subjects (p =.05). Similarly, serum creatinine, urea, sodium and chloride were significantly higher with lower eGFR in hypertensive when compared with control group (p =.05). eGFR in female was significantly lower compared with male hypertensive (p = .05). The mean SBP and DBP were significantly higher in hypertensive compared with control group (p = .05).

Conclusion: 30% of the hypertensive subjects had multiple signs and symptoms of ADPKD, suggesting evidence of high prevalence of ADPKD in the hypertensive patients. Routine screening of family members with hypertension and symptomatic cases of hypertension using ultrasound imaging is strongly recommended for confirmation of presence PKD.
EXCHANGE RATE, GOLD PRICE, AND STOCK PRICE CORRELATION IN ASEAN-5: EVIDENCE FROM COVID-19 ERA
Authors: Arisandhi Vicho Dwindra , Robiyanto Robiyanto
Published: March 2022

ASEAN-5 (Indonesia, Singapore, Malaysia, Philippines, and Thailand) were the pillars of economies in the Southeast Asia. This study aimed to examine the dynamic correlation of exchange rate and gold price on stock price in ASEAN-5 countries during COVID-19 pandemic. This study used Asymmetric DCC-GARCH model and employed daily data from March 2020 to August 2021. For all cases, the findings showed the degree of correlations were similar to each other. Furthermore, the result revealed that exchange rate and gold price had weak correlations on stock price. During the pandemic, negative correlation confirmed the exchange rate was a better alternative asset than gold which was positively correlated with stock prices. The ASEAN-5 market participants should hereby evaluated their investment risk and strategy.
Análise dos Procedimentos e Critérios Necessários à Valoração de Propriedade Intelectual para a Transferência de Tecnologia no Âmbito dos Núcleos de Inovação Tecnológica (NITs)
Authors: Ferreira Ana Rita , Souza André Luis
Published: March 2022

A pesquisa teve por objetivo investigar os procedimentos e critérios necessários para a valoração de patentes no âmbito dos NITs. Para tanto, realizou-se uma pesquisa exploratória, de natureza bibliográfica e documental, com uma abordagem qualitativa, descritiva e analítica. Os resultados evidenciaram que a valoração de patente é fator importante ao processo de negociação de patentes. Observou-se também que os procedimentos e os critérios aplicados para mensurar o valor monetário de patentes no âmbito dos NITs incluem definir o tipo de contrato, a análise do ciclo de vida da patente – com a finalidade de identificar o impacto dos retornos esperados. Ademais, faz-se necessário identificar em qual estágio o invento está sendo valorado, considerando que a valoração sofre estágios diferentes. Por fim, é necessário, também, identificar o nível de prontidão tecnológica, pois o nível de maturidade impacta no valor da tecnologia.
Proposta de Intervenção para Inovação e Sustentabilidade da Vila Caramuru (Mercado do Peixe) na Cidade de Salvador – BA
Authors: Messias Thiago , Campos Cidinei , Rodrigues Marta , Rocha Driele , Teles Eduardo , Santana Marcelo
Published: March 2022

O presente trabalho aborda uma proposta de intervenção no âmbito da inovação e da sustentabilidade para a Vila Caramuru, localizada no Bairro do Rio Vermelho, na cidade de Salvador, Bahia. Para tal, foi necessária a realização de levantamento “in loco” das demandas e necessidades dos proprietários e usuários do espaço, por meio de visitas técnicas, registro fotográfico e aplicação de questionário. Como resultado, obteve-se um diagnóstico da Vila Caramuru, apontando-se as reais necessidades e as demandas para melhor funcionamento do local. Em seguida, foi apresentada a proposta de intervenção, tendo como foco a inovação e a sustentabilidade, promovendo, também, a integração do espaço da associação dos pescadores, ora abandonado e isolado pela última intervenção realizada pela Prefeitura. Nas considerações finais, a presente proposta destaca a humanização da Vila com a participação harmônica dos atores envolvidos no ambiente com mais áreas verdes, acessibilidade e áreas de convivência.
Educação Empreendedora na Base da Inovação: análise de um Case de sucesso no empreendedorismo catarinense de base universitária
Authors: Zaak Saraiva Illyushin , Butzen Eduardo , Morejon Camilo Freddy Mendoza
Published: March 2022

A Educação Empreendedora pode ser entendida como uma metodologia educacional voltada a desenvolver competências individuais relacionadas à geração de valor para a comunidade e à competência em inovar e agir de forma autônoma, buscando a sustentabilidade, e a literatura brasileira e estrangeira apresenta exemplos de atividades educacionais nas quais foi possível despertar em estudantes de diversos níveis características típicas do empreendedor, como agente promotor do empreendedorismo. Este trabalho exploratório e descritivo busca identificar possíveis elos entre a adoção de Atividades Educacionais de Formação em Empreendedorismo (AEFEs) em turmas da disciplina Empreendedorismo em cursos de Bacharelado em Engenharia, em um campus de um Instituto Federal do Estado de Santa Catarina, e os resultados obtidos pelos alunos em concursos e competições de ideias de negócio organizados pelo Sebrae-SC e pelo Governo Estadual. Resultados mostram correlação entre o número de alunos inscritos em concursos e o número de trabalhos classificados, concluindo-se ser positiva a metodologia adotada na disciplina.
Bases de Dados de Patentes: uma análise a partir do portal de periódicos da CAPES
Authors: Araujo Geovane Gomes de , Marques Moreira Etelvina Maria , Araujo Josimary Horta de , Santos Soares Maria Elizabeth , Carvalho Joelia Marques de
Published: March 2022

Esta pesquisa analisa as bases de dados de patentes disponibilizadas no Portal de Periódicos da Capes com o objetivo de apresentar informações sobre as características de cada base, considerando-se os critérios utilizados no processo de busca e recuperação da informação na análise dos documentos de patentes. Trata-se de bases acessíveis por meio eletrônico, com abrangência nacional e internacional e cobertura de todos os campos tecnológicos. Desse modo, este trabalho possibilita a análise de informações tecnológicas contidas nas bases de patentes como um recurso informacional estratégico para a atividade de prospecção de novas tecnologias. A análise das bases de patentes do Portal da Capes possibilita um conhecimento mais profundo do potencial e da limitação de cada base para a obtenção de informações consistentes que possam colaborar na realização de estudos futuros. A pesquisa mostra que as informações patentárias podem ser disponibilizadas e grandemente utilizadas dentro de universidades e centros de pesquisa.
Catálogo de Ações da Agência UNEB de Inovação Durante o Ano de 2018 com Base na Estratégia Nacional de CT&I do Brasil 2016-2022
Authors: De Vasconcelos e Araujo Kim , Saba Pereira Cardoso Hugo , De Freitas Jorge Eduardo Manuel
Published: March 2022

A presente pesquisa reúne proposições participativas de intervenção na Agência UNEB de Inovação, Núcleo de Inovação Tecnológica da UNEB, através de um catálogo, visando ao fortalecimento do setor num cenário adverso dentro do Sistema Local de Inovação da Bahia, bem como servir de referência para tomada de decisões em outros ambientes semelhantes. Para o feito, a metodologia adotada foi a pesquisa-ação em consonância com a Estratégia Nacional de Ciência, Tecnologia e Inovação 2016-2022 do Ministério da Ciência, Tecnologia, Inovações e Comunicações do Brasil. O trabalho, então, reuniu seis propostas de intervenção durante o ano de 2018 esmiuçadas e catalogadas. Ao final, a pesquisa discute os benefícios do Catálogo de Ações da Agência UNEB de Inovação durante o ano de 2018 como uma ferramenta de diálogo não só com a Estratégia Nacional de CT&I do Brasil 2016-2022, mas também com a nova legislação e sua roupagem proposta para os NIT.
Empreendedorismo e Transferência Tecnológica: uma análise da atuação das incubadoras de empresas da Amazônia
Authors: De Oliveira Márcio Luis Góes , Filho Cirilo Simões , Mendonça Cláudio Márcio Campos de , Júnior Walter Teixeira Lima
Published: March 2022

Transferência tecnológica (TT) é um processo de troca de conhecimentos e habilidades tecnológicas entre organizações. Há diversos instrumentos para a viabilização da TT, entre elas as incubadoras de empresas, organismos que têm como missão o fortalecimento da cultura empreendedora, associadas à política de inovação das ICTs. Assim, este artigo objetivou analisar como as incubadoras de empresas da Amazônia atuam para apoiar a transferência das tecnologias dos empreendimentos incubados. A abordagem ao problema foi qualitativa e quantitativa, com estudo de casos. Utilizou-se como referência as incubadoras membros da Associação Nacional de Entidades Promotoras de Empreendimentos Inovadores (ANPROTEC). Os sites institucionais das incubadoras pouco têm detalhado como funcionam os processos de apoio à transferência tecnológica e também a descrição dos instrumentos de negociação, valoração e prontidão tecnológica (TRL). Um ponto relevante refere-se ao uso de parcerias no processo de TT como solução para limitações das ICTs amazônicas.
Mapeamento Tecnológico sobre as Técnicas de Obtenção de Óleo de Resíduos de Peixe
Authors: Ferreira Amanda Guimarães , Braga Patricia Regina Sobral
Published: March 2022

A pesca é uma atividade econômica significativa, pois possui importância na alimentação humana. Entretanto tal atividade gera um grande volume de resíduos. Esses rejeitos podem ser utilizados como matéria-prima na produção de subprodutos do pescado. Dentre as maneiras de agregar valor aos resíduos estão: consumo animal, consumo humano, produção de farinha, obtenção de colágeno, preparação de biodiesel ou a produção de óleo de peixe. O presente trabalho teve por objetivo a realização de um mapeamento tecnológico para conhecer as técnicas de extração de óleo a partir dos resíduos de peixe. Para a realização do artigo foi realizada uma busca em bancos de patentes (INPI, EPO, JPO e USPTO) assim como a utilização da ferramenta Orbit® Intelligence. A maioria das patentes encontradas é chinesa, e a principal técnica utilizada para obtenção do óleo baseia-se na limpeza dos resíduos, com posterior corte, cocção, prensagem e centrifugação.
Estudo Prospectivo Sobre o Uso da Cinza de Casca de Arroz em Catalisadores Heterogêneos
Authors: De Oliveira Mariana Andrade Rodrigues , Braga Patricia Regina Sobral
Published: March 2022

A cinza de casca de arroz (CCA) é um resíduo proveniente da agricultura e tem se mostrado como potencial poluidor. Esse artigo teve por objetivo realizar um estudo sobre a aplicação da CCA na síntese de catalisadores ou como suporte catalítico. Para tal, foi utilizada uma metodologia de prospecção realizada na perspectiva tecnológica, com busca no sítio do INPI e no sistema Orbit® Intelligence. O estudo tecnológico revelou que no sítio do INPI nenhuma patente estava relacionada ao uso de CCA como catalisador. Em relação a base de dados Orbit® Intelligence, a China se destacou como país com mais depósitos de patentes. Foram recuperadas 26 famílias de patentes, na qual se observou que o código C01B-039/02 é o principal representante. O mapeamento realizado mostrou que os estudos sobre CCA em síntese de catalisadores e/ou como suporte catalítico têm crescido com o passar dos anos.