bluuebunny/crossref_metadata_2025 huggingface dataset:
20 Years of global climate change governance research: taking stock and moving forward
Authors: Pattberg Philipp , Kaiser Cille , Widerberg Oscar , Stripple Johannes
Published: March 2022

Research on global climate change governance is no longer primarily concerned with the international legal regime, state practice and its outcomes, but rather scrutinizes the intricate interactions between the public and the private in governing climate change. This broad trend has also taken center stage within the pages of INEA. Two decades after its establishment, we sketch the main theoretical debates, conceptual innovations and empirical findings on global climate change governance and survey the new generation of climate governance scholarship. In more detail, we sketch how climate governance research has developed into three innovative sub-debates, building on important conceptualizations and critical inquiries of earlier debates. Our aim is not so much to provide an all-encompassing assessment of global climate change governance scholarship in 2022, but rather to illustrate in what important ways current research is different from research in the early phase of INEA, and what we have learned in the process. First, we discuss scholarship on the bottom-up nature of climate governance, developing from earlier ideas on agency beyond the state and the transnationalization of governance arenas. Second, we review contributions that have more systematically engaged with the concept of governance architectures, resulting in a stimulating new academic debate on the characteristics of complex governance systems and the consequences of governance complexity and fragmentation. Third, we note a distinct normative turn in global environmental scholarship in general and global climate governance in particular, associated with question of access, accountability, allocation, fairness, justice and legitimacy. The assessment of each of these debates is centered around questions of effective and legitimate climate governance to counter the climate emergency. Finally, as a way of concluding, we critically reflect on our own scholarly shortcomings and suggest a modest remedy.
Controlling microstructure evolution and phase transformation behavior in additive manufacturing of nitinol shape memory alloys by tuning hatch distance
Authors: Zhu Jia-Ning , Borisov Evgenii , Liang Xiaohui , Huizenga Richard , Popovich Anatoly , Bliznuk Vitaliy , Petrov Roumen , Hermans Marcel , Popovich Vera
Published: March 2022

Laser powder bed fusion (L-PBF), categorized as additive manufacturing technique, has a capability to fabricate NiTi (Nitinol) shape memory alloys with tailorable functional properties and complex geometries. An important processing parameter, hatch distance (h), is often related to macroscale structural defects; however, its role on controlling the microstructure and functional properties is usually underestimated in L-PBF of NiTi. In this work, equiatomic NiTi (50.0 at% Ni) parts were fabricated with various hatch distances to tailor the microstructure and their shape memory characteristics. Contrary to what is observed in Ni-rich NiTi alloys, in this work, we demonstrate that phase transformation temperatures of L-PBF equiatomic NiTi do not decrease proportionally with hatch distance but rather relate to a critical hatch distance value. This critical value (120 μm) is derived from the synergistic effect of thermal stress and in situ reheating. Below this value, epitaxial grain growth and in situ recrystallization are enhanced, while above, irregular grains are formed and dislocations induced by thermal stresses decrease. However, the critical value found herein is characterized by high dislocation density and fine grain size, resulting in a superior thermal cyclic stability. The proposed finite element model is proven to be an effective tool to understand and predict the effect of hatch distance on grain morphology and dislocation density evolutions in L-PBF NiTi SMAs. In the present study, we provide a comprehensive understanding for in situ controlling L-PBF NiTi microstructure and functional characteristics, which contributes to designing 4-dimensional shape memory alloys.
Effects of Iron and Vitamin A Levels on Pregnant Women and Birth Outcomes: Complex Relationships Untangled Using a Birth Cohort Study in Uganda
Authors: Mezzano Julieta , Namirembe Grace , Ausman Lynne M. , Marino-Costello Elizabeth , Shrestha Robin , Erhardt Juergen , Webb Patrick , Ghosh Shibani
Published: March 2022

Introduction

Women and infants are among the most vulnerable groups for micronutrient deficiencies. Pregnancy micronutrient status can affect birth outcomes and subsequent infants’ growth.

Methods

We determined the relationship between maternal iron and vitamin A status at delivery using several biomarkers (ferritin, soluble transferrin receptor [sTFR], body iron stores [BIS], hemoglobin and retinol binding protein [RBP]) and birth outcomes (body weight, Z-scores, head circumference, small-for-gestational-age and preterm birth) in rural Uganda. We investigated women who had serum results at the point of delivery and paired them to their infants at birth (n = 1244). We employed multivariable linear and logistic regression, adjusting for clustering at the subcounty level to determine the relationship between maternal micronutrients and birth outcomes.

Results

After adjusting for relevant factors, we found that maternal iron status (ferritin and BIS) and anemia (hemoglobin) were not significantly associated with the assessed birth outcomes. However, there was a significant association between serum sTFR and preterm births (AOR: 0.67; 95% CI 0.48–0.94). For Vitamin A, we observed a significant positive association between RBP and length-for-age (LAZ) at birth (β = 0.12, p < 0.030).

Discussion

These findings indicate that the relationship between maternal iron status and birth outcomes needs to be further investigated, because depending on the biomarker used the associations were either in favor of an adverse birth outcome or not significant. Additionally, they confirm that higher maternal RBP levels could be beneficial for birth outcomes.

Clinicaltrials.gov as NCT04233944.
Virtual conference design: features and obstacles
Authors: Hurst William , Withington Adam , Kolivand Hoshang
Published: March 2022

The Covid-19 pandemic has forced a change in the way people work, and the location that they work from. The impact has caused significant disruption to education, the work environment and how social interactions take place. Online user habits have also changed due to lockdown restrictions and virtual conferencing software has become a vital cog in team communication. In result, a spate in software solutions have emerged in order to support the challenges of remote learning and working. The conferencing software landscape is now a core communication solution for company-wide interaction, team discussions, screen sharing and face-to-face contact. Yet the number of existing platforms is diverse. In this article, a systematic literature review investigation on virtual conferencing is presented. As output from the analysis, 67 key features and 74 obstacles users experience when interacting with virtual conferencing technologies are identified from 60 related open-source journal articles from 5 digital library repositories.
Exploring the role of ride-hailing in trip chains
Authors: Ahmed Tanjeeb , Hyland Michael
Published: March 2022

Ride-hailing can potentially provide a variety of benefits to individuals who need to chain several activities together within a single trip chain, relative to other travel modes. Using household travel diary/survey data, the goal of this study is to assess the role ride-hailing currently plays within trip chains. Specifically, the study aims to determine, within trip chains, who uses ride-hailing services, for what trip/activity purposes, and to/from what types of areas, as well as the characteristics of trip chains that involve ride-hailing segments. To meet these objectives, the study estimates a binary logit model using 2017 National Household Travel Survey data, where the dependent variable denotes the inclusion of at least one ride-hailing trip within a trip chain. Similar to the non-trip-chaining ride-hailing literature, this study indicates that trip chains with ride-hailing legs are positively associated with travelers who are younger, live in high-income households, frequently use transit, and reside in high-density areas. However, this study includes novel findings indicating statistically significant relationships between ride-hailing and trip chains that end in healthcare and social/recreational activities. Moreover, trip chains with ride-hailing tend to have fewer stops and longer activity durations than trip chains without ride-hailing. This study also includes nested logit choice models, wherein the dependent variable denotes the primary mode (ride-hailing, transit, personal vehicle, or non-motorized transport) of a trip chain. These model results provide additional insights into the role of ride-hailing within trip chains, as they allow for cross-mode comparisons. The paper discusses the potential transportation planning and policy implications of the model results as well as future research directions.
Longitudinal Patterns of Material Hardship Among US Families
Authors: Thomas Margaret M. C.
Published: March 2022

Material hardship has emerged as a direct measure of deprivation in the United States and an important complement to income poverty, providing different evidence about the ways in which deprivation may affect wellbeing. This study addresses gaps in our knowledge about deprivation as the first to examine patterns of material hardship over time. Using data from the Fragile Families and Child Well-Being Study, this study examined five material hardship types (food, housing, medical, utility, and bill-paying) experienced at five timepoints over 15 years. Employing latent class analysis and latent transition analysis, this study identified six longitudinal patterns of material hardship experience, characterized by trajectories of stability or movement and relative severity of material hardship experience over time. These findings improve our conceptual understanding of deprivation and move us towards understanding the impacts of material hardship on wellbeing and identifying policy approaches to prevent deprivation or mitigate negative consequences.
Sensitivity Analysis and Quantification of the Role of Governing Transport Mechanisms and Parameters in a Gas Flow Model for Low-Permeability Porous Media
Authors: Sandoval Leonardo , Riva Monica , Colombo Ivo , Guadagnini Alberto
Published: March 2022

Recent models represent gas (methane) migration in low-permeability media as a weighted sum of various contributions, each associated with a given flow regime. These models typically embed numerous chemical/physical parameters that cannot be easily and unambiguously evaluated via experimental investigations. In this context, modern sensitivity analysis techniques enable us to diagnose the behavior of a given model through the quantification of the importance and role of model input uncertainties with respect to a target model output. Here, we rely on two global sensitivity analysis approaches and metrics (i.e., variance-based Sobol’ indices and moment-based AMA indices) to assess the behavior of a recent interpretive model that conceptualizes gas migration as the sum of a surface diffusion mechanism and two weighted bulk flow components. We quantitatively investigate the impact of (i) each uncertain model parameter and (ii) the type of their associated probability distribution on the evaluation of methane flow. We then derive the structure of an effective diffusion coefficient embedding all complex mechanisms of the model considered and allowing quantification of the relative contribution of each flow mechanism to the overall gas flow.
COVID-19-bedingte Online- vs. Präsenzlehre: Differentielle Entwicklungsverläufe von Beanspruchung und Selbstwirksamkeit in der Lehrkräftebildung?
Authors: Hußner Isabell , Lazarides Rebecca , Westphal Andrea
Published: March 2022

Bedingt durch die COVID-19-Pandemie haben Universitäten die Lehrkräftebildung in den vergangenen Monaten rasant auf Online-Formate umstellen müssen. Für eine evidenzbasierte Weiterentwicklung der Online-Lehre sind empirische Ergebnisse zur professionellen Entwicklung von Lehramtsstudierenden erforderlich. Vor diesem Hintergrund ist es wichtig, Unterschiede zwischen Präsenz- und Onlineformaten in der Lehre zu untersuchen. In der vorliegenden Studie gehen wir daher der Frage nach, inwiefern sich Selbstwirksamkeitserwartungen und Beanspruchungserleben von Lehramtsstudierenden im Verlauf eines COVID-19 bedingten Online-Semesters sowie im Verlauf von schulpraxisbezogenen Präsenzsemestern differentiell entwickeln. An der längsschnittlichen Fragebogenstudie mit quasi-experimentellem Design nahmen N = 240 Lehramtsstudierende teil (n = 127 Online-Semester; n = 113 Präsenzsemester). Die Ergebnisse verweisen auf einen stärkeren Anstieg der Selbstwirksamkeitserwartungen in Präsenzformaten als im Onlineformat. In Bezug auf das Beanspruchungserleben zeigten sich keine Gruppenunterschiede. Implikationen dieser Befunde für die Weiterentwicklung der Lehrkräftebildung werden weiterführend diskutiert.
Mitral valve surgery for atrial functional mitral regurgitation: predicting recurrent mitral regurgitation and mid-term outcome
Authors: Kawamoto Naonori , Fukushima Satsuki , Kainuma Satoshi , Ikuta Ayumi , Tadokoro Naoki , Kakuta Takashi , Fujita Tomoyuki
Published: March 2022

Objectives

This study aimed to elucidate the mid-term outcomes and risk factors for recurrent mitral regurgitation after mitral valve (MV) surgery for atrial functional mitral regurgitation (AFMR).

Methods and results

We retrospectively analyzed data of 50 consecutive patients (median age 74 years; 29 men) who underwent mitral valve surgery for AFMR between January 2001 and January 2019. Mean atrial fibrillation duration was 12 years. During the follow-up period of 4.6 ± 4.4 years, 5 cardiac-related deaths were identified. Five- and 10-year freedom from cardiac-related death rate for all patients was 88.4% and 78.6%. In total, 42 patients underwent MV repair with mitral annuloplasty and 8 underwent MV replacement. Five- and 10-year freedom from cardiac-related death rate in patients who underwent MV repair was 93.1% and 82.7%, which was better than MV replacement (log rank p = 0.04). During the follow-up period, MR recurrence rate was 16.8% at 5 and 10 years for the patients who underwent MV repair. Univariate analysis showed that partial band annuloplasty and preoperative elevated left ventricular end-systolic volume index were risk factors for recurrent MR after MV repair. Multivariate analysis identified partial band annuloplasty as the independent predictor for recurrent MR during long-term follow-up after MV repair for AFMR.

Conclusion

Patients who underwent MV repair for AFMR could have an acceptable mid-term outcome. However, MVR might not improve the mid-term outcome in patients with AFMR. The use of partial bands for mitral annuloplasty would not be recommended in terms of recurrent MR mid-term.
Global Longitudinal Strain Monitoring to Guide Cardioprotective Medications During Anthracycline Treatment
Authors: Marwick Thomas H.
Published: March 2022

Purpose of the Review

Anthracycline chemotherapy carries a risk of myocardial dysfunction and heart failure even at relatively low doses, and the clinical prediction of cancer treatment-related cardiac dysfunction (CTRCD) is inexact. Careful imaging or biomarker surveillance during chemotherapy can identify CTRCD before the development of heart failure. Currently, this surveillance is performed using ejection fraction (EF). While this is a reliable and reproducible test with three-dimensional techniques, the most widely used imaging technique is two-dimensional echocardiography, for which EF measurements have broad confidence intervals.

Recent Findings

The use of global myocardial strain (GLS) provides a more reliable and reproducible means of assessing global cardiac function and shows meaningful changes before a significant change of EF. Observational studies have shown that although absolute measurements of GLS, both at baseline and during therapy, are predictive of CTRCD risk, the most reliable approach is to assess the change of GLS with therapy — a meaningful relative change of 10–15% being significant. A clinical trial comparing GLS to EF surveillance did not show a significant change of EF in the overall study group, but did show that patients managed with a the GLS-guided approach were less likely to develop a meaningful change of cardiac function to an abnormal level. In at-risk patients, there is good evidence for the protective value of neurohormonal antagonists and statins: the use of GLS enables these benefits to be directed to those most likely to benefit, while minimizing their use in the majority of people, who do not need them.

Although GLS requires an element of training and efforts to ensure uniformity, it has proven to be a feasible, robust, and reproducible technique, ready for wide adoption.
Neo-liberal or not? Creeping enclosures and openings in the making of fisheries governance
Authors: Parlee Courtenay , Foley Paul
Published: March 2022

Neo-liberalism can mean different things from different perspectives. Social scientists tend to use the concept to identify and critique trends of privatization, marketization, commodification and enclosures, and their associated slew of exclusionary, dispossessive, and regressive effects. Counterintuitively, governmentality analyses identify how practices of collaboration, inclusion, participation, and empowerment—practices sometimes cited as means to resist and generate alternatives to neo-liberalism—are not only consistent with neo-liberal governing but also central to its functioning. This paper engages a biopolitics and governmentality analytical perspective to examine different kinds of fisheries policies in Newfoundland and Labrador (NL), Canada, where the historic cod collapse created a laboratory for examining social-ecological effects of capitalist overexploitation, resource mismanagement, and knowledge system blind spots. The case is useful because it includes, on the one hand, practices traditionally seen as reinforcing neo-liberal governance, such as property making, resource management access rationalization, and global eco-labels, and, on the other hand, practices where linkages to neo-liberalism require more critical assessment, such as fisher-influenced professionalization policies, license collaboration/consolidation initiatives, and producer-oriented eco-labels. Drawing on a governmentality perspective, this paper examines how governance change in NL fisheries is driven not by a single regulatory logic but, rather, by diverse “technologies of government” and “technologies of agency.” Diverse technologies of agency, with varying degrees of links to neo-liberalism, facilitate “creeping” enclosures and openings for fish harvesters in NL fisheries. The paper finds that multi-faceted social protection and coastal community-oriented rationalities of fisher groups are key explanatory variables in shaping practices for and against neo-liberal governance, suggesting that the relationship of diverse neo-liberal, moral economy and hybrid governmentalities to lived experiences requires more empirical and theoretical attention.
Maltodextrin-Based Carbohydrate Oral Rinsing and Exercise Performance: Systematic Review and Meta-Analysis
Authors: Hartley Claudia , Carr Amelia , Bowe Steven J. , Bredie Wender L. P. , Keast Russell S. J.
Published: March 2022

Background

Carbohydrates are an important fuel for optimal exercise performance during moderate- and high-intensity exercise; however, carbohydrate ingestion during high-intensity exercise may cause gastrointestinal upset. A carbohydrate oral rinse is an alternative method to improve exercise performance in moderate- to high-intensity exercise with a duration of 30–75 min. This is the first systematic review and meta-analysis to comprehensively examine the isolated effect of maltodextrin-based rinsing on exercise performance.

Objective

The objective of this review was to establish the effect of a maltodextrin-based carbohydrate oral rinse on exercise performance across various modes of exercise. Furthermore, a secondary objective was to determine the effects of moderators [(1) participant characteristics; (2) oral rinse protocols; (3) exercise protocol (i.e. cycling, running etc.) and (4) fasting] on exercise performance while using a maltodextrin-based, carbohydrate oral rinse.

Methods

Five databases (MEDLINE, PsycINFO, Embase, SPORTDiscus and Global Health) were systematically searched for articles up to March 2021 and screened using Covidence (a systematic review management tool). A random effects robust meta-analysis and subgroup analyses were performed using Stata Statistical Software: Release 16.

Results

Thirty-five articles met the inclusion criteria and were included in the systematic review; 34 of these articles were included in the meta-analysis. When using a conventional meta-analytic approach, overall, a carbohydrate oral rinse improved exercise performance in comparison with a placebo (SMD = 0.15, 95% CI 0.04, 0.27; p = 0.01). Furthermore, when implementing an adjusted, conservative, random effects meta-regression model using robust variance estimation, overall, compared with placebo, a carbohydrate oral rinse demonstrated evidence of improving exercise performance with a small effect size (SMD = 0.17, 95% CI − 0.01, 0.34; p = 0.051).

Conclusion

This systematic review and meta-analysis demonstrates that a maltodextrin-based carbohydrate oral rinse can improve exercise performance. When comparing the two meta-analytic approaches, although non-significant, the more robust, adjusted, random effects meta-regression model demonstrated some evidence of a maltodextrin-based carbohydrate oral rinse improving exercise performance overall.
Trait Anxiety in Individuals on the Autism Spectrum: a Systematic Review
Authors: Jolliffe Rebecca , Adams Dawn , Simpson Kate
Published: March 2022

Although anxiety is commonly researched in autism, the focus has predominantly been on anxiety disorders and not upon general levels of anxiousness or trait anxiety. This review summarises research investigating trait anxiety in autism. Systematic searches yielded 1099 records, with 23 studies meeting inclusion criteria. Study participants were mainly males from Western countries, with no representation of older adults or individuals with intellectual disability. All articles used self-report questionnaire trait anxiety measures. Anxiety measure psychometric details were absent in most studies, with 21 using subjective measures that are not validated for use in autism. Results showed higher trait anxiety scores in autism versus control groups, and correlations between trait anxiety scores and other study outcomes.
L’irisina: un ormone con benefici multiorgano
Authors: Le Grazie Giulia , Marrano Nicola , Natalicchio Annalisa , Giorgino Francesco
Published: March 2022

Sommario

L’irisina è una miochina secreta dal muscolo scheletrico in seguito ad attività fisica, in grado di regolare l’omeostasi glucidica ed energetica, agendo su numerosi tessuti e intervenendo su diversi pathways metabolici. Un’alterazione dei livelli sierici di irisina potrebbe promuovere l’insorgenza di patologie metaboliche, tra cui il diabete mellito di tipo 2. Numerosi studi su modelli animali di diabete e/o obesità hanno dimostrato che la somministrazione di irisina esogena è in grado di esercitare effetti antidiabetici e antiobesità.
Life Cycle Gap Analysis for Product Circularity and Sustainability—a Case Study with Three Different Products
Authors: Dieterle Michael , Viere Tobias
Published: March 2022

This paper aims to demonstrate the applicability and benefits of life cycle gap analyses for systematically integrating circular economy considerations into life cycle assessment. It presents life cycle gap analyses for three entirely different products (rechargeable batteries, T-shirts, plastic bottles), compares the applications and results, and draws conclusions on the usefulness of the method.

The case studies reveal life cycle gaps of 54% (plastic bottles), 61% (rechargeable batteries), and 98% (T-shirts), indicating high potential for further circularity improvements in the current life cycle systems of different industries and product groups. At the same time, a potential weakness of the method is underlined. Even considering options to increase circularity, life cycle gaps of at least 45% still exist, raising the question of what measures are really needed in order to achieve product circularity and sustainability. The analysis demonstrates the general applicability of life cycle gap analyses and their contribution to the integration of circular decision-making and life cycle thinking.
Plant phosphate nutrition: sensing the stress
Authors: Satheesh Viswanathan , Tahir Ayesha , Li Jinkai , Lei Mingguang
Published: March 2022

Phosphorus (P) is obtained by plants as phosphate (Pi) from the soil and low Pi levels affects plant growth and development. Adaptation to low Pi condition entails sensing internal and external Pi levels and translating those signals to molecular and morphophysiological changes in the plant. In this review, we present findings related to local and systemin Pi sensing with focus the molecular mechanisms behind root system architectural changes and the impact of hormones and epigenetic mechanisms affecting those changes. We also present some of the recent advances in the Pi sensing and signaling mechanisms focusing on inositol pyrophosphate InsP8 and its interaction with SPX domain proteins to regulate the activity of the central regulator of the Pi starvation response, PHR.
The Dreadful Word
Authors: Olbertson Kristin A.
Published: March 2022

This book, the first comprehensive study of criminal speech in eighteenth-century New England, traces how the criminalization, prosecution, and punishment of speech offenses in Massachusetts helped to establish and legitimate a social and cultural regime of politeness. Analyzing provincial statutes and hundreds of criminal prosecutions, Kristin A. Olbertson argues that colonists transformed their understanding of speech offenses, from fundamentally ungodly to primarily impolite. As white male gentility emerged as the pre-eminent model of authority, records of criminal prosecution and punishment show a distinct cadre of politely pious men defining themselves largely in contrast to the vulgar, the impious, and the unmanly. “Law,” as manifested in statutes as well as in local courts and communities, promoted and legitimized a particular, polite vision of the king's peace and helped effectuate the British Empire. In this unique and fascinating work, Olbertson reveals how ordinary people interacted with and shaped legal institutions.
Atomic-Scale Analytical Tomography
Authors: Kelly Thomas F. , Gorman Brian P. , Ringer Simon P.
Published: March 2022

A comprehensive guide on Atomic-Scale Analytical Tomography (ASAT) that discusses basic concepts and implications of the technique in areas such as material sciences, microscopy, engineering sciences and several interdisciplinary avenues. The title interrogates how to successfully achieve ASAT at the intersection of transmission electron microscopy and atom probe microscopy. This novel concept is capable of identifying individual atoms in large volumes as well as in 3D, with high spatial resolution. Written by leading experts from academia and industry, this book serves as a guide with real-world applications on cutting-edge research problems. An essential reading for researchers, engineers and practitioners interested in nanoscale characterisation, this book introduces the reader to a new direction for atomic-scale microscopy.
Hurricane Michael and Adverse Birth Outcomes in the Florida Panhandle: Analysis of Vital Statistics Data
Authors: Harville Emily W. , Pan Ke , Beitsch Leslie , Sherchan Samendra P. , Gonsoroski Elaina , Uejio Christopher , Lichtveld Maureen Y.
Published: March 2022

Objective:

The aim of this study was to examine birth outcomes in areas affected by Hurricane Michael.

Methods:

Vital statistics data of 2017–2019 were obtained from the state of Florida. Births occurring in the year before and after the date of Hurricane Michael (October 7, 2018) were used. Florida counties were divided into 3 categories reflecting extent of impact from Hurricane Michael. Birth outcomes including incidence of preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) were also compared before and after Hurricane Michael. Spontaneous and indicated PTBs were distinguished based on previously published algorithms. Multiple regression was used to control for potential confounders.

Results:

Both LBW (aRR 1.19, 95% CI: 1.07, 1.32) and SGA (aRR 1.11, 95% CI: 1.01, 1.21) were higher in the year after Michael than the year before in the most-affected area; a similar effect was not seen in other areas. A stronger effect was seen for exposure in the first trimester or in the 2 months after Michael than in the second or third trimester.

Conclusion:

Consistent with many previous studies, this study of Hurricane Michael found an effect on fetal growth.
Aerodynamics of a wing in turbulent bluff body wakes
Authors: Zhang Z. , Wang Z. , Gursul I.
Published: March 2022

The aerodynamics of a stationary wing in a turbulent wake are investigated. Force and velocity measurements are used to describe the unsteady flow. Various wakes are studied with different dominant frequencies and length scales. In contrast to the pre-stall angles of attack, the time-averaged lift increases substantially at post-stall angles of attack as the wing interacts with the von Kármán vortex street and experiences temporal variations of the effective angle of attack. At an optimal offset distance from the wake centreline, the time-averaged lift becomes maximum despite of small amplitude oscillations in the effective angle of attack. The stall angle of attack can reach 20° and the maximum lift coefficient can reach 64 % higher than that in the freestream. Whereas large velocity fluctuations at the wake centreline cause excursions into the fully attached and separated flows during the cycle, small-amplitude oscillations at the optimal location result in periodic shedding of leading edge vortices. These vortices may produce large separation bubbles with reattachment near the trailing-edge. Vorticity roll-up, strength and size of the vortices increase with increasing wavelength and period of the von Kármán vortex street, which also coincides with an increase in the spanwise length scale of the incident wake, and all contribute to the remarkable increase in lift.
Experimental properties of continuously forced, shear-driven, stratified turbulence. Part 2. Energetics, anisotropy, parameterisation
Authors: Lefauve Adrien , Linden P.F.
Published: March 2022

In this Part 2 we study further experimental properties of two-layer exchange flows in a stratified inclined duct, which are turbulent, strongly stratified, shear-driven and continuously forced. We analyse the same state-of-the-art data sets using the same ‘core’ shear-layer methodology as in Part 1 (Lefauve & Linden, J. Fluid Mech., vol. 937, 2022, A34), but we focus here on turbulent energetics and mixing statistics. The detailed analysis of kinetic and scalar energy budgets reveals the specificity and scalings of ‘SID turbulence’, while energy spectra provide insight into the current strengths and limitations of our experimental data. The anisotropy of the flow at different scales characterises the turbulent kinetic energy production and dissipation mechanisms of Holmboe waves and overturning turbulence. We then assess standard mixing parameterisation models relying on uniform eddy diffusivities, mixing lengths, flux parameters, buoyancy Reynolds numbers or turbulent Froude numbers, and we compare our representative values with the stratified mixing literature. The dependence of these measures of mixing on controllable flow parameters is also elucidated, providing asymptotic estimates that may be extrapolated to more strongly turbulent flows, quantified by the product of the tilt angle of the duct and the Reynolds number. These insights may serve as benchmark for the future generation of experimental data with superior spatio-temporal resolution required to probe increasingly vigorous turbulence.
Association between healthy lifestyle pattern and early onset of puberty: based on a longitudinal follow-up study
Authors: Li Yanhui , Gao Di , Chen Manman , Ma Ying , Chen Li , Ma Jun , Dong Yanhui
Published: March 2022

The present study aimed to explore the association between healthy lifestyle pattern and childhood early onset of puberty. Based on a cohort study in Xiamen of China, a total of 1294 children was followed for three and a half years. Children’s lifestyles, including dietary behaviour, physical activity, sleep duration, smoking and drinking behaviour and sedentary behaviour, were collected by questionnaires. Healthy lifestyle pattern was determined mainly according to the recommendations by the Dietary Guidelines for Chinese school-age children and Canadian Guidelines for children and youth. The pubertal development was assessed by clinical examination according to Tanner stages. The association between pre-pubertal lifestyle and early onset of puberty was estimated using linear regression and log-binomial regression. We found that children who adhered to a healthy lifestyle had a 0·36-year delay of the age of puberty onset (coef = 0·36, 95 % CI (0·08, 0·65)) and 53 % lower risk of early onset of puberty (risk ratio = 0·47, 95 % CI (0·27, 0·80)), compared with those who had a poor lifestyle. However, the beneficial effect of favourable lifestyles on the early onset of puberty was found only in boys with normal weight. Boys who adhered to active physical activity and low sedentary behaviour had a relatively delayed age of puberty onset (coef = 0·49, 95 % CI (0·26, 0·72)). This is the first time to find that healthy lifestyle pattern was associated with a substantially lower risk of early onset of puberty, especially in boys with normal weight. Advocating an integrated healthy lifestyle is essential for the development of children.
Weighting the relative importance of behaviors affecting gait score
Authors: Jones Barbara , Tsai I. Ching , Chang Yu-Mei , Bewley Jeffrey
Published: March 2022

This research communication evaluates experts’ opinions on the importance and weights of six gait aspects. In 2016, a Qualtrics (Qualtrics LLC., Provo, Utah) survey was distributed to lameness experts. Six gait aspects – general symmetry, tracking, spine curvature, head bobbing, speed and abduction as well as adduction were included. Respondents were asked to rank the gait aspects from 1 (most important) to 6 (least important), and to indicate which weight each gait aspect should receive when assessing lameness. For each gait aspect, frequency (percentage %) was used to describe the distribution of rank, and medians as well as 25th and 75th percentiles were used to summarize assigned weights. Thirty-nine percent of respondents ranked general symmetry first, followed by 32% for tracking, and 19% ranked spine curvature third. Head bobbing ranked fourth with 10% whereas, speed, abduction and adduction were not ranked. The median, 25th and 75th percentiles weight for each gait aspect were: general symmetry (25, 15, and 30), tracking (20, 10, and 30), spine curvature (20, 10, and 21), head bobbing (15, 10, and 20), speed (10, 5, and 20), and abduction and adduction (10, 5, and 10). General symmetry and tracking were deemed the most important gait aspects. A composite gait score can be calculated based on weighted importance of different gait aspects to indicate possible lameness.
On heat conduction in an irregular magnetic field. Part 1
Authors: Helander Per , Hudson Stuart R. , Paul Elizabeth J.
Published: March 2022

Anisotropic heat conduction in a plasma embedded in a magnetic field with irregular, possibly chaotic, field lines is discussed. If the collisional mean free path exceeds the electron gyroradius, the heat conductivity is much larger along the field lines than across them, and this enhances the transport across a domain where good flux surfaces do not exist. Recognising that anisotropic heat conduction may be cast in a variational form, and by constructing increasingly sophisticated trial functions that are based on invariant and almost-invariant structures under the magnetic field-line flow, bounds are derived on this enhancement and on the temperature variation along the magnetic field. In this way, remarkably accurate approximations for the temperature can be rapidly constructed without solving the diffusion equation, even in the small perpendicular-diffusion limit when the solution for the temperature is dominated by the fractal structure the magnetic field lines.
A validated high-throughput method for assaying rat lungworm (Angiostrongylus cantonensis) motility when challenged with potentially anthelmintic natural products from Hawaiian fungi
Authors: Rollins Randi L. , Qader Mallique , Gosnell William L. , Wang Cong , Cao Shugeng , Cowie Robert H.
Published: March 2022

Parasitic nematodes devastate human and animal health. The limited number of anthelmintics available is concerning, especially because of increasing drug resistance. Anthelmintics are commonly derived from natural products, e.g. fungi and plants. This investigation aimed to develop a high-throughput whole organism screening method based on a motility assay using the wMicroTracker system. Anthelmintic activity of extracts from Hawaiian fungi was screened against third-stage larvae of the parasitic nematode Angiostrongylus cantonensis, categorized according to the degree of motility reduction. Of the 108 crude samples and fractionated products, 48 showed some level of activity, with 13 reducing motility to 0–25% of the maximum exhibited, including two pure compounds, emethacin B and epicoccin E, neither previously known to exhibit anthelmintic properties. The process of bioassay-guided fractionation is illustrated in detail based on analysis of one of the crude extracts, which led to isolation of lamellicolic anhydride, a compound with moderate activity. This study validates the wMicroTracker system as an economical and high-throughput option for testing large suites of natural products against A. cantonensis, adds to the short list of diverse parasites for which it has been validated and highlights the value of A. cantonensis and Hawaiian fungi for discovery of new anthelmintics.
Parasite communities in English Sole (Parophrys vetulus) have changed in composition but not richness in the Salish Sea, Washington, USA since 1930
Authors: Preisser Whitney C. , Welicky Rachel L. , Leslie Katie L. , Mastick Natalie C. , Fiorenza Evan A. , Maslenikov Katherine P. , Tornabene Luke , Kinsella John M. , Wood Chelsea L.
Published: March 2022

Earth is rapidly losing free-living species. Is the same true for parasitic species? To reveal temporal trends in biodiversity, historical data are needed, but often such data do not exist for parasites. Here, parasite communities of the past were reconstructed by identifying parasites in fluid-preserved specimens held in natural history collections. Approximately 2500 macroparasites were counted from 109 English Sole (Parophrys vetulus) collected between 1930 and 2019 in the Salish Sea, Washington, USA. Alpha and beta diversity were measured to determine if and how diversity changed over time. Species richness of parasite infracommunities and community dispersion did not vary over time, but community composition of decadal component communities varied significantly over the study period. Community dissimilarity also varied: prior to the mid-20th century, parasites shifted in abundance in a seemingly stochastic manner and, after this time period, a canalization of community change was observed, where species' abundances began to shift in consistent directions. Further work is needed to elucidate potential drivers of these changes and to determine if these patterns are present in the parasite communities of other fishes of the Salish Sea.
Speech representation used by Mandarin Chinese-speaking children aged three to six years
Authors: GUAN Wei , LIU Haitao
Published: March 2022

This study investigates how Mandarin Chinese-speaking children use Mandarin Chinese, a language lacking tense markers, to represent characters’ speech in their story narratives. Eighty participants, from three to six years of age, completed an elicited narrative task based on a wordless picture book. The representing forms and signals that they employed in representing activities were assessed. The results showed a significant age-related increase in the overall use of speech representation by the cohort of children. Regarding representing forms, direct representation exhibited its expected dominance among all age groups, and its presence in children’s narratives grew significantly with age. Concerning representing signals,shuō‘say’ was the most prevalent across all ages and susceptible to significant age effects, and, with advancing age, children’s representing signals expanded from single verbs to more complex syntactic constructions. In addition, no significant gender effects were observed regarding the representing forms or signals that Mandarin-speaking children used.
Korean-speaking children’s constructional knowledge about a transitive event: Corpus analysis and Bayesian modelling
Authors: SHIN Gyu-Ho , MUN Seongmin
Published: March 2022

We investigate Korean-speaking children’s knowledge about clause-level constructions involving a transitive event – active transitive and suffixal passive – through corpus analysis and Bayesian modelling. The analysis of Korean caregiver input and children’s production in CHILDES revealed that the rates of constructional patterns produced by the children mirrored those uttered by the caregivers to a considerable degree and that the caregivers’ use of case-marking was skewed towards single form-function pairings (despite the multiple form-function associations that the markers manifest). Based on these characteristics, we modelled a Bayesian learner by employing construction-based input (without considering lexical information). This simulation revealed the dominance of several constructional patterns, occupying most of the input, and their inhibitory effects on the development of the other patterns. Our findings illuminate how children shape clause-level constructional knowledge in Korean, an understudied language for this topic, as a function of input properties and domain-general learning capacities, appealing to the usage-based constructionist approach.
Facial edema as an adverse drug reaction to olanzapine in a patient with cancer receiving palliative care
Authors: Julião Miguel , Sobral Maria Ana , Ferreira Tiago , Calaveiras Patrícia , Costa Elisabeth , Daniel Ana Sara , Lemos-Caldas Mafalda , Bruera Eduardo
Published: March 2022

Objective

Atypical neuroleptics such as olanzapine are indicated for the treatment of various psychiatric disorders and have been used in the palliative care setting also for several clinical indications. Peripheral and facial edema are a rare side effect of the treatment with olanzapine. We report a case of an advanced cancer patient cared receiving palliative care who developed severe facial edema after initiating a low dose of olanzapine in monotherapy.

Method

A patient with advanced cancer who presented with severe facial edema after initiating olanzapine for the treatment of her opioid use disorder.

Results

After excluding other differential diagnosis for facial edema, olanzapine was discontinued with complete resolution of the edema.

Significance of results

To the best of our knowledge, this is the first case reporting facial edema due to olanzapine treatment in a patient with advanced cancer. Our report will help clinicians recognize the possible role of olanzapine in cases of rapid onset of facial edema, allowing its rapid resolution.
Exploring the domestic and international drivers of professionalization of Central and Eastern European interest groups
Authors: Dobbins Michael , Horvath Brigitte , Labanino Rafael Pablo
Published: March 2022

While there has been a veritable boom in literature on organized interests, their lobbying strategies, relationships with decision-makers, and their impact on policymaking, only a few studies have explored internal organizational developments and, specifically, the professionalization of interest groups. The present study focuses on the national and transnational factors driving the professionalization of interest groups in Central and Eastern Europe, a region previously neglected in much of the interest group literature. Based on a sample of more than 400 surveyed organizations operating in Poland, the Czech Republic, Hungary, and Slovenia in the healthcare, higher education, and energy sectors, we explore three bundles of factors potentially enhancing the professionalization of interest groups – organizational funding sources, national and transnational intergroup cooperation and organizations’ standing in the domestic interest group system. Our statistical analyses show that state subsidies and tight policy coordination with the state are crucial drivers of internal organizational professionalization, suggesting rather patronistic and symbiotic relationships between the state and certain organizations. However, our data also support the notion that interorganizational collaboration, both at the national and international levels, may also be key to organizational professionalization, enabling groups that lack close ties with the state to compensate their disadvantage with intensive domestic and international networking. The study is also among the first to link increasing professionalization with organizational population density.
Competitive mimicry: The socialization of antifeminist NGOs into the United Nations
Authors: Cupać Jelena , Ebetürk Irem
Published: March 2022

Conservative NGOs contesting women’s rights in the United Nations are on the rise, and their activity is increasingly described as an antifeminist backlash. This article focuses a new theoretical lens on this development: socialization. It argues that conservative NGOs’ socialization into transnational practices and the United Nations has played a significant part in facilitating the antifeminist backlash. To support this claim, the article examines socialization comprehensively, applying several analytical angles: its definition, directionality, mechanism, degree and effects. It also treats conservative NGOs’ socialization as both a process and an outcome. As a process, it unfolds horizontally, by conservative NGOs competitively mimicking feminist NGOs in two domains in particular: their manner of transnational organizing and their skilful use of the UN human rights framework. The article finds that conservative NGOs have socialized into transnational NGO practices and the regulative institutional rules of the United Nations, but not into all its constitutive norms. The chief effect of this kind of socialization is polarization. The article singles out and empirically illustrates three of its manifestations: the struggle for institutional spaces; zero-sum politics based on a sense of existential threat; and the use of a strong moralizing discourse.