bluuebunny/crossref_metadata_2025 huggingface dataset:
Sosok Perempuan Dalam Puisi “Asyhadu An Lâ Imra’ata Illâ Anti” Karya Nizar Qabbani
Authors: Hayati Dewi Lutfiana , Syafaah Daris
Published: February 2022

Abstract

Poetry research with the title "I  witness that there is no woman Apart From  You" by Nizar Qabbani. Poetry has beautiful words that describe social conditions even to the point of economic and political. The purpose of this study was to find out the meaning contained in the poem "I  witness  There Is No Woman Besides You and to know the aspects of the signified and the aspect of the signifier.  The form of the formulation of the problem contained in this poem are: 1) What are the characteristics of women in the poem "I bear witness that there is no woman but you"? 2) How does the female figure compare the poet to the poem?. The method used in this study uses qualitative methods. And this research was studied using semiotic analysis. Semiotics is the study of signs and meanings contained in literary works. The findings of this study are that there are aspects of signifier and signified . the characteristics of women described in the verses of the poem "I witness there is no woman but you". While the results of the research in this poem explain the figure of a woman, namely the most loved wife, who is able to nurture and care for her patiently which is like taking care of her young child, tough, affectionate, patient and able to accompany the poet in times of joy and sorrow.

Keywords: Poetry, I Witness There Is No Woman Apart From You, Semiotics

 

Asbtrak

 Penelitian puisi dengan judul “ Asyhadu An La> Imra’ ata Illa< Anti ” karya Nizar Qabbani. Puisi memiliki kata-kata yang indah yang menggambarkan keadaan sosial bahkan sampai ekonomi dan politik.  Tujuan penelitian ini untuk mengetahui makna yang terkandung dalam puisi “Aku Bersaksi Tiada Perempuan Selain Engkau, dan mengetahui aspek petanda dan paspek penanda. Bentuk rumusan masalah yang terdapat dalam puisi ini yaitu: 1) Bagaimana sifat-sifat wanita yang terdapat dalam puisi  “Aku Bersaksi Tiada Perempuan Selain Engkau”? 2) Bagaimana sosok wanita tersebut mengumpamakan sang penyair pada puisi tersebut?. Adapun metode yang digunakan dalam penelitian ini menggunakan metode kualitatif. Dan penelitian ini dikaji menggunakan analisis semiotika. Semiotika adalah ilmu yang mengkaji tentang tanda dan makna yang terdapat dalam karya sastra. Adapun temuan dari penelitian ini yaitu terdapat aspek petanda dan penanda, sifat-sifat wanita yang dijelaskan pada bait-bait puisi “Aku Bersaksi Tiada Perempuan Selain Engkau”. Sedangkan hasil penelitian dalam puisi ini menjelaskan sosok wanita yaitu istri yang paling dicintai, yang mampu mengayomi serta merawat dengan telaten yang diibaratkan seperti merawat anaknya yang masih kecil, tangguh, kasih sayang, penyabar dan mampu mendampingi sang penyair dalam keadaan suka maupun duka.

Kata Kunci: Puisi, Aku Bersaksi Tiada Perempuan Selain Engkau, Semiotika
Identification of Strata from Irregularities in Well Logs Using Chaos Quantifiers
Authors: Figiel Michal , Lewandowska-Smierzchalska Joanna
Published: February 2022

Estimating a transition between rock types from well logs using traditional methods can be challenging and time-consuming. Developing new approaches to improving the quality of the estimation as well as saving time becomes necessary. This paper presents a new methodology that uses elements of chaos theory to evaluate the variability of well logs to identify rock layers.

Four different parameters that quantify chaos were used in the present study: fractal correlation dimension, sample entropy, Hurst exponent, and Lyapunov exponent. Each of them describes a different property of a well log. The method presented in this paper uses all of them together for an extensive characterization of well log irregularities. The study was carried out on a set of 68 well logs from six wells in the Pluto gas field (Australia). The logs were divided into segments of 25 m. A computer program was written to calculate the chaos parameter values of each interval. The parameters were then analyzed statistically. Hierarchical methods and k-means clustering were used to create dendrograms and clusters.

The statistical analysis of the results has shown that the well log variability can be used to successfully differentiate rock formations by showing which intervals on a log are similar. In addition, the intervals that correspond to Mungaroo sandstones, which are the reservoir rock of the Pluto gas field, were particularly distinguished from other parts of the log. Therefore, the presented methodology could prove useful to estimate zones of interest in terms of hydrocarbon potential.

The presented algorithm accounts for the variability of the well log readings, not the log values themselves. It does not point exactly to a depth where rock layers interface, but it rather allows similar (in terms of irregularities), consecutive intervals to be grouped together. Based on that, one can draw a conclusion that a lithology differs between groups of intervals.
Peri-operative Management and the Role of Minimally Invasive Spine Surgery in a Case of Hemophilia B
Authors: Goparaju VNR Praveen , Chugh Amit , Rangnekar Ameya , Kundnani Vishal
Published: February 2022

Hemophilia A and B are rare X-chromosome-linked recessive bleeding disorders caused by mutations in the genes causing abnormalities of blood clotting factors VIII and IX, respectively. Surgery in these patients will require additional planning and interaction among the surgeon, anesthetist, and a hematologist because they inevitably result in bleeding, excessive blood loss, and other life-threatening complications. The authors present a case 62-year-old male with haemophilia B and progressive neurological claudication. On plain radiographs and MRI the patient had grade 1 spondylolisthesis with lumbar canal stenosis at L4-L5 with a VAS score of 8 and ODI score of 45 and was operated with MIS-TLIF with 22 mm diameter tubular retractor (METRx, Medtronics) and an operating microscope. Pre-operatively, the hematologist opinion was taken and the patient was optimised by maintaining the plasma factor peak level activity according to the WFH guidelines. The patient had uneventful peri-operative period. The total hospital stay is 16 days and a VAS score of 3 and ODI score of 12 after one-year follow-up and without any notable complications. Minimally invasive surgical techniques are a better option in hemophilia patients as these techniques provide the surgeon with an excellent magnification of the operative field, which enables the use of a smaller incision, better hemostasis, and facilitates less traumatic procedures.
Conscience Clause in the Professional Practice of a Nurse and Midwife: A Cross-Sectional Study
Authors: Iwanowicz-Palus Grażyna , Mróz Mariola , Kruczek Agnieszka , Rusińska Anna , Szlendak Beata
Published: February 2022

Background
Attitudes toward the conscience clause are a manifestation of the compromise between the conscience of the health care provider and the welfare of the patient. The aim of the study is to distinguish types of approaches of nurses and midwives to the conscience clause and factors that affect them.
Methods
The research was conducted by means of the Generalized Self-Efficacy Scale (the GSES) and a standardized questionnaire in the group of 270 nurses and 262 midwives (Poland).
Results
Nurses are characterized by three types of attitudes to the conscience clause: radically conservative, radically liberal as well as liberal-conservative. In the group of midwives moderately liberal, rational-liberal and radically conservative types of approaches were found. Factors that differentiate the attitude of nurses and midwives to the conscience clause include type of medical procedure, place of residence, education, maternal experience, seniority, attitude to faith in God and self-efficacy.
Conclusions
It is desirable for nursing and midwifery professionals to take steps toward addressing moral dilemmas through education, well-designed workplace guidelines, and engagement in research to uncover underlying barriers.
Fruquintinib in Combination with PD-1 Inhibitors in Patients with Refractory Non-MSI-H/pMMR Metastatic Colorectal Cancer: A Real-World Study in China
Authors: GOU miaomiao , Qian Niansong , Zhang Yong , Yan Huan , Si Haiyan , wang zhikuan , Dai Guanghai
Published: February 2022

Background: Fruquintinib, a vascular endothelial growth factor receptor inhibitor, is a new anti-cancer drug independently developed in China to treat refractory metastatic colorectal cancer (mCRC). In Japan, regorafenib in combination with nivolumab has demonstrated promise in patients with refractory mCRC. Here, in a real-world study, we aimed to evaluate the efficacy of fruquintinib plus various programmed death-1 (PD-1) inhibitors after standard treatment in Chinese non- microsatellite instability-high(MSI-H)/mismatch repair proficient mCRC patients.Methods: Thirty-five patients with refractory mCRC were involved in the study. They were given fruquintinib (3 or 5 mg orally, once daily for 3 weeks followed by 1 week off in 4 week cycles) and a PD-1 inhibitor. Progression free survival (PFS), overall survival (OS), disease control rate (DCR), and objective response rate (ORR) were reviewed and evaluated. Results: Of the 35 patients, the median age was 54 years (29–85). The ORR was 11.4% (4/35), DCR was 60% (21/35), median PFS was 3.8 months, and median OS was 14.6 months. The duration of response was 3.4 months. The PFS between left and right primary tumors as well as whether lung metastases were present did not differ (p > 0.05), which is inconsistent with the REGONIVO study. The multivariate analysis indicated no association of OS benefit in the specified subgroups. No adverse-effect-related deaths were reported.Conclusions: Fruquintinib in combination with anti-PD-1 was observed to have clinical activity in a small population of patients with heavily pretreated mCRC. The improvements in OS need to be verified using more real-world medical data.
Relationship Between Patient-reported Orofacial-dental Pain Severity and Tele-triage Decisions During COVID-19 Pandemic - Does the Severity of Pain Drive Tele-triage Decisions?
Authors: Ali Shaymaa , Ansari Walid El
Published: February 2022

BACKGROUND: Globally, withCOVID-19 pandemic, elective dental services were stopped, and only urgent/ emergency conditions were managed face-to-face after tele-triage(TT). However, no previous researchexploredwhetherthe severity of orofacial/ dental pain (OFDP)drivesthe TT decisions.The current report undertook this task.METHODS: This retrospective cross-sectional reportanalyzed the pain severity (PS) reported byhotline callers during the first COVID-19 lockdownand its association with patient's age,sex, history of chronic illness,and dental discipline required. PS was also compared across triage categories, associated dental history and tentative tele-diagnosis. PS was measured using self-reported numerical rating scale (NRS-11).Binomial logistic regression assessed the associationbetweenthe PS (exposure) and likelihoodof being referred for face to face management, controlling for age, sex, history of chronic illness, and dental discipline needed. ANOVA compared pain severity (PS) across dental history and tentative diagnosis.RESULTS:PS was significantly associated with TT decisions (p<0.05). An increase in pain score by 1 unit was associated with 1.4 times increased odds of face-face referral. Pediatric/ adolescent patients (9-18 years) were 2.1 times more likely, and those with chronic illness were 2.12 times more likelyto be referred for face-to-facemanagement.Among the dental specialties, surgical and orthodontic specialties were each associated with increased odds of referral (1.9 and 7.016 respectively) compared to restorative specialties.The highest PS was highest for the emergency triage category (8.00 ± 2.83, P< 0.0001),adults (6.29 ± 2.1819, P< 0.0001),and the tentative tele-diagnosis of cellulitis (7.75 ± 2.872, P< 0.0001).CONCLUSIONS: TT decisions were significantly influenced by severity of patient-reported OFDP, adjusting for a range of variables. However, acute dental conditions were not referred when they were judged to be manageable remotely; and conversely, less acute dental conditions were given the attention they required and referred when they hadpotential life threating or quality of life implications. Consideringsuch tele-approach after the pandemic has subsided might be safe and useful in a range of scenarios and healthcare facilities.
New Approach Based on Fuzzy Hypergraphs in Granular Computing (An Application to the Urban Vulnerability Assessment)
Authors: Baghini Abdolreza Zarandi , Babaei Hojjat , Mirhosseini Ramin Tabatabaei
Published: February 2022

Classifying objects based on the simultaneous impact of various parameters has always been challenging due to heterogeneity, impact conflict, and sometimes parameter uncertainty. The purpose of this study is to provide a method for classifying such data. In the proposed method, fuzzy hypergraphs were used to define the granular structures in order to apply the simultaneous effect of heterogeneous and weighted parameters in the classification. This method has been implemented and validated on Fisher intuitive research in relation to the classification of iris flowers. Evaluation and comparison of the proposed method with Fisher’s experimental and results showed higher efficiency and accuracy in flower classification. The proposed method has been used to assess the seismic risk of 50,000 buildings based on 10 heterogeneous parameters. Seismic risk classification showed that more than 88% of buildings were classified, and 12% of buildings that could not be classified due to excessive scatter of parameter values were classified using a very small confidence radius. The results indicate the ability of the proposed method to classify objects with the least similarity and number of effective parameters in classification.
Release Strategies of Telenomus Podisi for Control of Euschistus Heros: A Computational Modeling Approach
Authors: Weber Igor Daniel , Garcia Adriano Gomes , Bueno Adeney de Freitas , Freitas Regiane Cristina de Oliveira , Godoy Wesley Augusto Conde
Published: February 2022

The egg-parasitoid wasp Telenomus podisi has received attention as a biological-control agent for one of the most important soybean pests in Brazil, the stink bug Euschistus heros. As yet, no studies have conclusively established strategies for the release of T. podisi. We developed a computational model employing cellular automata to investigate release strategies for T. podisi in soybean crops, in order to optimize the use of these wasps in managing E. heros. A computational model was developed, using cellular automata in the C programming language and assuming a two-dimensional grid of cells corresponding to a soybean field. The biological dynamics of E. heros and T. podisi were programmed. The following parameters for release strategy were investigated: release mode, number of releases, number of parasitoids per hectare per release, and spacing between release points or strips. The sensitivities of the release and movement parameters were analyzed. The release strategies capable of maintaining an E. heros population below the Economic Threshold level involved releasing a total of at least 15,000 female parasitoids per hectare, in three or four releases of 5,000 or more. A 25-m spacing between release points or strips was indicated. The theoretical results produced by the computational model are expected to guide future field studies to improve T. podisi release plans for managing E. heros in soybeans.
Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells.
Authors: Nishino Teppei , Yoshihara Masaharu , Nakayama Takahiro , Tsuchiya Takaho , Tahara Saeko , Ozaki Haruka , Takahashi Satoru
Published: February 2022

Objective: Portal mesenchymal cells induces the epithelial differentiation of the bile ducts in the developing liver via one of the Delta-Notch signaling components, JAGGED1. Although this differential induction is crucial for normal liver physiology as its genetic disorder (Alagille syndrome) causes jaundice, the molecular mechanism behind JAGGED1 expression remain unknown. Here, we searched for upstream regulatory transcription factors of JAGGED1 using an integrated bioinformatics method.Results: According to DoRothEA database, which integrated multiple lines of evidence on the relation between transcription factors and its downstream target genes, three transcription factors were predicted to be upstream of JAGGED1: SLUG, SOX2 and EGR1. Among these, SLUG and EGR1 were enriched in ACTA2 expressing portal mesenchymal cells in the previously reported two human fetal liver single cell RNA-seq data. JAGGED1 expressing portal mesenchymal cells tended to express of SLUG rather than EGR1, supporting that SLUG induced JAGGED1 expression. Together with the higher confidentiality of SLUG (DoRothEA level A) over EGR1 (DoRothEA level D), we concluded that SLUG was one of the most important candidate transcription factors upstream of JAGGED1. These results would add mechanistic insights into developmental biology on how portal mesenchymal cells supports biliary development in the liver.
Theoretical study on the reactions of C2H5 with CnH2n+1OH (n = 1 - 4): Predicted rate constants and branching ratios
Authors: Nguyen Trong-Nghia , Tuan Vu Anh , Bac Phung Thi Viet , Anh Le Phuoc , Nguyen Hue Minh Thi
Published: February 2022

The mechanisms of the reactions of C2H5 with CnH2n+1OH (n = 1-4) have been investigated by CCSD(T)//B3LYP/6-311++G(3df,2p) for n = 1 - 3 and CCSD(T)//B3LYP/6-311+G(d,p) for n = 4. Our chemical quantum results show that the C2H5 + CH3OH reaction can take place via H-abstraction or substitution channels. The former is the major channel with barrier energies of 13.0 and 14.4 kcal/mol while the latter has to pass over much higher barriers of 42.2 – 52.3 kcal/mol. Similarly, the C2H5 + CnH2n+1OH (n = 2 - 4) reactions can mainly occur via H-abstraction channels with barrier energies of 10.4 - 16.4 kcal/mol. The b-H abstraction channel has the lowest barrier energy (11.7 kcal/mol) for t-C4H9OH while o/a-H abstraction channels have the lowest barrier energies (10.4 - 13.0 kcal/mol) for the others. The rate constants and product branching ratios for individual channels as well as total rate constants have been calculated for the temperature range 300-2500 K by TST theory with Eckart tunneling corrections. The optimized geometries of the related species and predicted heats of reactions agree well with available data.
The Driving Effect Of Technological Innovation On Green Development: Dynamic Efficiency Spatial Variation
Authors: Cheng Manli , Wen Zongguo , Yang Shanlin
Published: February 2022

High-tech industry has become an important position for international competition due to its strong technological innovation capabilities. Green development of the manufacturing industry is an important measure to respond to the profound changes in the global manufacturing industry, and technological innovation is the core force to drive the green development of the manufacturing industry. However, DEA model usually employed to measure the efficiencies of the innovation and green development, the internal transmission mechanism has not been thoroughly explored. In order to open the black box, this paper utilize the high-tech industry data to measure the efficiency of technological innovation process by using network Slack Based Measure (NSBM), Global Malmquist Luenberger index model (GML) is employed to evaluate and decompose the green development efficiency of high-tech industry, and the influencing mechanism between the efficiency of technological innovation and the efficiency of green development is explored by the spatial Dubin model. The results indicate that green transformation of the manufacturing industry has an obvious spatial linkage effect. In addition, technological innovation efficiency is conducive to the green development efficiency, while economic transformation efficiency and urbanization are not conducive to the green development efficiency.
Introduction and Propagation Properties of Circular Lorentz-Bessel-Gaussian Beams
Authors: Ebrahim Ahmed Abdulrab Ali , Yahya Nabil A.A. , Swillam Mohamed , Belafhal Abdelmajid
Published: February 2022

In this paper, circular Lorentz–Bessel–Gaussian beams (CLBGBs) are introduced as a novel member of the Lorentz-Gaussian beams family. The analytical expression of the propagation of these beams passing through a paraxial optical ABCD system is derived. The generalized Huygens-Fresnel diffraction integral of the form Collins’s formula and the expansion of the Lorentz distribution in terms of the complete orthonormal basis set of the Hermite-Gauss modes are used. The influences of the beam-order and Bessel part β, Gaussian and Lorentzian waists, and propagation distance z on the propagation of CLBGBs are investigated. Some numerical simulation results are done. The beams family in this work may be useful to the practical applications in free-space optical communications because they have vortex properties with their being experimentally realizable.
Anesthesia Aspects of Multivisceral Transplantation: A Case Series Study
Authors: Khalili Fatemeh
Published: February 2022

Background
Multi-visceral transplantation (MVTx) usually refers to the transplantation of more than three intra-abdominal organs. A successful MVT procedure requires strong multidisciplinary teamwork of transplant surgeons, anesthesiologists, and intensivists.
Case presentation:
We present 5 cases of MVT with a history of short bowel syndrome admitted to the Abu-Ali Sina Hospital, Shiraz, Iran between May 2019 and January 2020 and describe anesthetic considerations in MVT. Subjects were identified (4F/1M) with a mean age of 43 years old (range 35–51). The most frequent criterion was Portal vein thrombosis followed by bowel gangrene and short bowel syndrome. The mean ±SD duration of the operation was 360±60 min. The approximate bleeding volume was 2600 ±1474 cc and the 4±1 bag packed red blood cells were transfused.
Conclusion
Careful preoperative planning, vigilant intraoperative anesthetic management, and prevention of postoperative infection are imperative to reach the best outcomes.
Prediction of the diagnostic and prognostic values of homeobox family in lung cancer using bioinformatics
Authors: HU TINGTING , Gao PanJun , Jiang Min , Li Zheng , Xu Dan , Jing Jing , WANG JING
Published: February 2022

Background: Lung cancer is a frequently diagnosed malignancy and accounts for the main reason of cancer-related deaths worldwide due to the less of reliable diagnostic markers and the potent therapeutic targets. Therefore, exploration of the molecular mechanisms underlying the occurrence and development via systems biology approaches provides a promising option. Here, we aimed to reveal genes which could be used as the diagnostic and prognostic markers in lung cancer, aiming to find new efficient target for treatment using bioinformatics method. Results: We adopted a series of bioinformatics methods to identify genes which are implicated in the progression of lung cancer. From the raw RNA microarray data obtained from the database of UCSC-Xena, we identified that a total of 241 differently expressed genes (DEGs), including 8 HOX (homeobox) genes in all types of lung cancer tissues (Stage I-IV) as compared to the normal lung tissues. The gene ontology (GO) analysis showed that the 241 DEGs were mainly enriched in xenobiotic glucuronidation, regionalization, GABA receptor complex, and extracellular ligand-gated ion channel activity. Gene expression profiling interactive analysis (GEPIA) demonstrated that the expression levels of HOXA11, HOXA13, HOXB9, HOXB13, HOXC11, HOXC13, HOXD11 and HOXD13 were all obviously higher in lung adenocarcinoma and squamous cell lung carcinoma tissues than in normal lung tissues. Kaplan-Meier survival analysis and operating characteristic analyses (ROC) suggested that the high expression of HOXA11/A13/B9/B13/C11/C13/D11/D13 all predicted poor prognosis of lung cancer and had high specificity and sensitivity in distinguishing lung cancer patients from healthy individuals. Conclusion: This study using bioinformatics methods identified that 8 genes (HOXA11/A13/B9/B13/C11/C13/D11/D13) of HOX family might play an important role in lung cancer progression with high value in the diagnosis and prognostic prediction in lung cancer. However, their role in lung cancer progression still need to be verified using the fundamental experiments.
Prenatal Exposure to Diethylhexyl Phthalate Impairs the Recovery of Spatial Memory Post-traumatic Brain Injury in a Sex-specific Manner
Authors: Sun Min Kyoung , Kaimal Amrita , Latchoumane Charles-Francois V , Forghani Rameen , Lenear Christopher E , Holmes Phillip V , Mohankumar Sheba M.J , Karumbaiah Lohitash
Published: February 2022

Background
Diethyl hexyl phthalate (DEHP) is a chemical plasticizer that causes significant neurological impairments after prenatal exposure. The impact of these exposures on cognitive recovery after severe traumatic brain injury (sTBI) has never been studied. We hypothesized that prenatal exposure to DEHP will impair cognitive recovery after a sTBI in a sex-specific manner.
Methods
To test this hypothesis, six-month-old male and female offspring that were prenatally exposed to DEHP were subjected to controlled cortical impact injuries, and their spatial memory was tested weekly using a Morris Water Maze (MWM) test for 4 weeks post-sTBI.
Results
We observed that DEHP-exposed male rats demonstrated significantly impaired spatial memory up to four weeks post-sTBI when compared to controls. In contrast, DEHP-exposed female rats showed no detectable impairment in spatial memory recovery compared to injured controls. These observations were accompanied by marked increases in neurotransmitter levels in the cortex and dopamine levels in the hippocampus of female, but not in male rats. No significant differences in lesion area and number of hippocampal neurons were observed in both sexes.
Conclusion
These results suggest that prenatal exposure to DEHP may have long lasting effects in the brain that could lead to impaired recovery specifically in male subjects following post-sTBI.
Autoimmune Lymphoproliferative Syndrome (Alps) Disease and Alps Phenotype: Are They Two Distinct Entities?
Authors: Palmisani Elena , Miano Maurizio , Grossi Alice , Lanciotti Marina , Lupia Michela , Terranova Paola , Ceccherini Isabella , Montanari Eugenia , Calvillo Michaela , Pierri Filomena , Micalizzi Concetta , Maggiore Rosario , Guardo Daniela , Zanardi Sabrina , Facchini Elena , Maggio Angela , Mastrodicasa Elena , Corti Paola , Russo Giovanna , Pillon Marta , Farruggia Piero , Cesaro Simone , Barone Angelica , Tosetti Francesca , Ramenghi Ugo , Crescenzio Nicoletta , Bleesing Jack , Dufour Carlo , Fioredda Francesca
Published: February 2022

Introduction
Autoimmune Lymphoprolypherative Syndrome (ALPS) is an inherited disorder of lymphocyte homeostasis classically due to mutation of FAS, FASL, and CASP10 genes (ALPSFAS/CASP10). In spite of recent progress, about one third of ALPS patients does not carry classical mutations and still remains gene orphan (ALPS-U, undetermined genetic defects).
Objective
The aims of the present study were to compare the clinical and immunological features of ALPSFAS/CASP10 vs those of ALPS-U affected subjects and to deepen the genetic characteristics of this latter group.
Methods
Demographical, anamnestic, biochemical data were retrieved from medical record of 42 ALPS subjects. An enlarged panel of genes (Next Generation Sequencing) was applied to the ALPS-U group.
Results
ALPS-U subjects showed a more complex phenotype if compared to ALPSFAS/CASP10 group, characterized by multi-organ involvement (p=0.001) and positivity of autoimmune markers (p= 0.02). Multilineage cytopenia was present in both groups without differences with the exception of lymphocytopenia and autoimmune neutropenia that were more frequent in ALPS-U than in ALPS-FAS/CASP10 group (p=0.01 and p=0.04). First and second line treatments were able to control the symptoms in 100% of the ALPSFAS/CASP10 patients, while 63% of ALPS-U needed more than two lines of treatment and remission in some cases was obtained only after target therapy. In the ALPS-U group, we found in 14/28 (50%) patients 19 variants; of these 4/19 (21%) were known as pathogenic, 8/19 (42%) as likely pathogenic. A characteristic flow cytometry panel including CD3CD4-CD8-+TCRαβ+, CD3+CD25+/CD3HLADR+, TCR αβ + B220+ and CD19+CD27+ identified the ALPS FAS/CASP10 group.
Trans-abdominal and Trans-gastric percutaneous drainage of peripancreatic infected collections: a retrospective analysis.
Authors: Rey Carlos , Conde Danny , Girón Felipe , Ayala Daniela , Gonzalez Juliana , Quintero Marco
Published: February 2022

PurposeAcute pancreatitis is one of the most common gastrointestinal diseases. Approximately 20% of the patients develop peripancreatic collections. Step-up management it’s now the best approach with less rate of morbidity and mortality compared with open or minimally invasive surgery. Percutaneous management could reach a success rate between 50-76%. Our study shows the outcomes of trans-gastric versus transabdominal percutaneous drainage in cases of peripancreatic collections. MethodsA retrospective review of a prospectively collected database was conducted. All the patients older than 18 years old that underwent percutaneous drainage between January 2010 – December 2021 were included. Analysis and description of outcomes such as mortality, complications, and avoidance of surgical procedures was performed.Results18 patients underwent percutaneous drainage. 66.67% of patients were male. Mean age was 52.55 ± 22.06 years. Mean weight was 74.43 ± 15.25 kg. Mean size of peripancreatic collections 118.4 ± 49.12mm. Wall-off necrosis was present in 33.33%. Trans-gastric approach was performed in 50% of the cases, the rest was trans-abdominal. No mortality was evidenced after 30 days of follow up. After trans-gastric percutaneous drainage, all patients avoided surgical open or laparoscopic procedureConclusionStandardized step-up approach shows increased rates of success in percutaneous drainage of peripancreatic collections. Based on our results, in the absence of interventionist endoscopy, percutaneous drainage (trans gastric or trans-abdominal) it’s a feasible and secure procedure. Further studies are needed.
Transcriptomic analysis of differential gene expression in staphylococcus aureus-induced pneumonia in pediatrics based on microarray analysis
Authors: Ehigie Adeola Folashade , Ojeniyi Fiyinfoluwa Demilade , Aborisade Adetayo , Agboola James Busayo , Ehigie Leonard
Published: February 2022

Staphylococcus aureus is a leading cause of about 80% of infections in humans and up to 60–70% of hospital-acquired infections. Pneumonia is the broad term for a range of disorders that result in infection of the lung parenchyma and are caused by a number of organisms. It is a common disease that affects people from all walks of life. Identification of an etiologic agent for pneumonia is critical in order to provide appropriate therapy and maintain epidemiological records. Study on the transcriptional profiling of patients infected with S. aureus is a pivot to the analysis of differentially expressed gene in the blood of patients infected with S. aureus. This study performed the analysis of gene expression dataset GSE30119 available on the Gene expression Omnibus (GEO) which is based on the hypothesis tested that patient clinical heterogeneity will be reflected in transcriptional profile heterogeneity. The study comprised 143 pediatric patients, with 44 healthy individuals, 81 pneumonia-free, and 18 pneumonia infection patients. We discovered a total of 54 genes related to S. aureus infection and 612 genes associated with Pneumonia. According to Gene Ontology (GO) functional and pathway enrichment studies, the S. aureus infection associated genes are predominantly engaged in the innate immune response, calcium-mediated signaling, Neutrophil extracellular trap formation, Formation of Fibrin Clot (Clotting Cascade). Whereas the genes associated with Pneumonia are enriched in adaptive immune response, inflammatory, Interferon alpha/beta signaling, TCR signaling, Gα(i) signalling events. This study shows differentially expressed genes and their biological activities in relation to S. aureus infection and Pneumonia, and it may provide more light on the underlying molecular mechanisms and possibly important gene signatures in Pneumonia development.
Decrease Rate of Platelet Count as a Marker for Complications of Preeclampsia: A Cross-Sectional Study
Authors: Mayama Michinori , Morikawa Mamoru , Yamada Takashi , Umazume Takeshi , Noshiro Kiwamu , Nakagawa Kinuko , Saito Yoshihiro , Chiba Kentaro , Watari Hidemichi
Published: February 2022

BackgroundThrombocytopenia is considered a sign of maternal organ damage of preeclampsia. However, platelet count distribution during pregnancy shifts downward even in uncomplicated women, and platelet counts in some uncomplicated women falls below the cutoff value of thrombocytopenia. Thus, not only absolute platelet counts number but also platelet count reduction rate may relate with adverse outcomes of preeclampsia. This study aimed to evaluate whether the overall platelet count reduction rate was associated with adverse outcomes of preeclampsia. MethodsThis retrospective study included 240 singleton pregnant women with preeclampsia. Overall platelet count reduction ≥30.0% was used as a cut-off value because 10–20% platelet counts reduction can be observed in uncomplicated pregnancy. The association between the overall platelet count reduction from the first trimester ≥30.0% and adverse outcomes; severe hypertension, uteroplacental dysfunction, maternal organ damage except for thrombocytopenia, and preterm delivery <34 gestational weeks were analyzed. Moreover, subgroup analysis was conducted in women without thrombocytopenia.ResultsA total of 95/240 (39.6%) of women had ≥30.0% of overall platelet count reduction from the first trimester. The incidences of maternal organ damage except for thrombocytopenia (12.4%, 22.1%; p = 0.047), and preterm delivery <34 gestational weeks (30.3%, 48.4%; p = 0.005) were higher in women with ≥30.0% of overall platelet count reduction than those otherwise. Even in women without thrombocytopenia (platelet counts ≥150 × 109/L), severe hypertension (66.2%, 85.4%; p = 0.018), and preterm delivery <34 gestational weeks (30.8%, 51.2%; p = 0.017) were more frequently observed in women with ≥30.0% of overall platelet count reduction than those otherwise.ConclusionsA ≥30.0% of overall platelet count reduction from the first trimester was associated with adverse outcomes of preeclampsia even in women without thrombocytopenia.
Cost of research and education activities in US colleges - scalability, complementarity, and heterogeneous efficiency
Authors: Shimao Hajime , Li Xiaoxiao , Price Michael , Kempes Chris
Published: February 2022

Universities in the United States are remarkably diverse in their efficiency, both in terms of research output and educational achievement. Recent work has highlighted how important this heterogeneity is by showing that different broad categories of institutions demonstrate different scaling relationships for various features as a function of the number of students. These differences in scaling relationships reflect differences in organizational goals, constraints, and strategies. In the existing literature, this heterogeneity is under-explored and often ignored due to the lack of appropriate data and methodological limitations. In this paper, we address this problem by exploiting a newly consolidated dataset and adopting a neural-network based method to infer cost functions for universities. Our analyses reveal (1) the specific economy of scale in two distinct output types (education and research), (2) the nature of the trade-off between research and education efficiency, and (3) significant efficiency differences across universities. Particularly, we show that while both research and education outputs generally exhibit an economy of scale, their scalability largely depends on their size and other institutional characteristics. Similarly, research and education activities are complementary to each other (economy of scope) only in some situations, particularly when the scale of production is small to medium. Consequently, the cost isoclines of universities are highly non-convex, implying the possibility of multiple optima that may explain the diverse strategies universities adopt, and potential efficiency gains from specialization. It also suggests that some basic assumptions of microeconomic models may not be empirically supported.
Comparison on FTIR Spectrum and Thermal Analysis for Four Types of Rehamnnia Glutinosa and Their Extracts
Authors: Zhang Maosen , Ding Rong , Hu Fang
Published: February 2022

Rehmannia glutinosa (R. glutinosa) is a plant material and widely used clinically in China. Due to different processing methods and various healing effects, there are four types of R. glutinosas (RR, RRP, RRC, and RRPC) and their corresponding extracts for convenient use. As complicated mixture systems, chemical components of R. glutinosa are very difficult to identify and discriminate. In order to effectively control its quality during processing, Fourier transform infrared spectroscopy (FTIR), second derivative spectrum, and thermal analysis were used in this study. It was found that the major active ingredients were retained in the extracts when extracted from their corresponded R. glutinosa and subtle differences could be distinguished by the second derivative spectrum. FTIR spectrum, second derivative spectrum, and thermal analysis are valid method to validate and identify plant material, traditional Chinese medicine material, as well as their corresponding extracts.
Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence
Authors: Chen Minfeng , Wang Yinzhao , Zhou Tailai , Weng Liang , Chen Hengxing , Wen Sijie , Dao Pinghong
Published: February 2022

Bladder cancer is the most prevalent cancer of the urinary system, but its pathogenesis is still poorly understood. Several reports have suggested that gene damage repair is highly correlated with tumor development and drug resistance, in which homologous recombination repair gene Rad54L, seems to play an important role, through yet unclear mechanisms. Therefore, this study stratified cancer patients by Rad54L expression in bladder cancer tissue, and high Rad54L expression was associated with a poor prognosis. Mechanistically, we demonstrate that high Rad54L expression promotes abnormal bladder tumor cell proliferation by changing the cell cycle and cell senescence. In addition, this study also suggests that Rad54L may be associated with p53, p21, and pRB in bladder cancer tissue. In summary, this study exposes Rad54L as potential a prognostic biomarker and precision treatment target in bladder cancer.
From plant genetics to environment of selection: exploring the drivers of fungal communities in the roots and rhizosphere of Brassica napus
Authors: Bazghaleh Navid , Li Yunliang , Vail Sally , Mamet Steven D , Siciliano Steven D. , Helgason Bobbi
Published: February 2022

PurposeOur aim was to characterize the fungal root and rhizosphere microbiomes of genetically diverse Brassica napus lines in a temporally-intensive, multi-site field study to assess the relative contributions of plant genetics, growth stage and environmental conditions to microbiome composition and to identify fungi that were associated with yield performance. MethodsSixteen B. napus lines were grown across three sites in the Canadian Prairies. Sixteen lines were sampled weekly for ten weeks at one site in 2016, as well as a subset of eight lines at the same site in 2017; the sixteen lines were sampled three times at three sites in 2017. The root and rhizosphere fungal microbiomes were assessed using amplicon sequencing of the fungal ITS region with the Illumina MiSeq. ResultsOverall, B. napus line was associated with only 2% of the variation in community structure. Constrained to within a single site-year, this association increased to between 4 and 16% and to between 25 and 37% in a single week within individual sites. The fungal core microbiome consisted of 38 ASVs; Olpidium, Fusicola, Fusarium, Gibberella, Mortierella, and Cutaneotrichosporon were the most abundant taxa with varied abundance during different B. napus growth stages. Thirteen ASVs across three growth stages were highly associated with B. napus yield. ConclusionOur results point to the potential to exploit the B. napus microbiome for improving plant performance by targeting the core taxa identified here as well as those that lead to greater fitness under more specific conditions.
Evaluation Of School Mental Health Promotion Program: A Qualitative Study
Authors: Borji Mitra , Naserbakht Morteza , Hajebi Ahmad , Fazeli Asal , Khorrami Zahra , Ranjbar Helia , Hajebi Amirali
Published: February 2022

Background: Due to the need to identify problems related to mental health among students and their proper management by offering specialized medical services to them, recently a relevant research project has been fully implemented in schools of all grades in Iran. Since the only way to measure the effectiveness and find the strengths and weakness of a program is to evaluate it, the present study aims to monitor and evaluate the mentioned project in order to improve the quality of project implementation, identify defects and shortcomings and upgrade the existing system. Methods: The present study was a qualitative study using conventional content analysis that used a semi-structured in-depth interview to obtain information from group of stakeholders. Selected instructors, teachers, principals and designers of the School Mental Health Promotion Program were the target of the study. Results: The findings of the present study were presented in four categories of program strengths, program weaknesses, factors preventing achievement of program objectives and recommendations for program improvement. It is to be noted that 14 subcategories were also devised, and finally, 50 codes were extracted. The overall results of the evaluation of the School Mental Health Program showed its effectiveness. Conclusions: The new and practical model of School Mental Health Program has opened a new perspective to school-based interventions. However, the expectation of full implementation and continuation of this program in the short term and with limited resources does not seem very realistic because making change is often challenging and fraught with problems and obstacles.
Prediction and Diagnosis of Respiratory Disease by Combining Convolutional Neural Network and Bi-directional Long Short-Term Memory Methods
Authors: Li Li , Ayiguli Alimu , Luan Qiyun , Yang Boyi , Gong Hui , Zulipikaer Abudureherman , Xu Jingran , Zhong Xuemei , Subinuer Yilamujiang , Ren Jiangtao , Zou Xiaoguang
Published: February 2022

Objective Based on the respiratory disease big data platform in southern Xinjiang, we established a model that predicted and diagnosed chronic obstructive pulmonary disease, bronchiectasis, pulmonary embolism and pulmonary tuberculosis, and provided assistance for primary physicians. Methods The method combined convolutional neural network (CNN) and long-short-term memory network (LSTM) for prediction and diagnosis of respiratory diseases. We collected the medical records of inpatients in the respiratory department, including: chief complaint, history of present illness, and chest computed tomography. Preprocessing of clinical records with“ jieba” word segmentation module, and the Bidirectional Encoder Representation from Transformers (BERT) model was used to perform word vectorization on the text. The partial and total information of the fused feature set was encoded by convolutional layers, while LSTM layers decoded the encoded information. Results The precisions of traditional machine-learning, deep-learning methods and our proposed method were 0.6, 0.81, 0.89, and F1 scores were 0.6, 0.81, 0.88, respectively. Conclusion Compared with traditional machine learning and deep-learning methods that our proposed method had a significantly higher performance, and provided precise identification of respiratory disease.
Impact Of A Specifically Designed Antenatal Class For First-Time Fathers On Their Experience Of Childbirth
Authors: Cornet Isabelle , de Tejada Begoña Martinez , Guittier Marie-Julia
Published: February 2022

Purpose: Most fathers describe the experience of witnessing childbirth as very positive, but some feel unsupported and excluded. Offering specific antenatal classes for fathers could improve their experience. This study compares the childbirth experience of first-time fathers who attended specific antenatal classes for men (intervention group) with those who did not (non-intervention group).Methods: We performed a comparative study at a tertiary maternity hospital in Switzerland using First-Time Father Questionnaire (FTFQ) one month after childbirth. We assessed the satisfaction of the specific antenatal classes with a questionnaire with open and closed questions.Results: A total of 121 fathers for the non-intervention group and 52 for the intervention group completed the FTFQ. The score of two of the three dimensions of the FTFQ were significantly better: the professional support was reduced from 1.98 (SD = 0.52) in the non-intervention group to 1.69 (SD = 0.55) in the intervention group, p = 0.001; and the prenatal preparation from 1.70 (SD = 0.57) to 1.48 (SD = 0.51) respectively, p = 0.019. In the intervention group, 75% of fathers-to-be felt better prepared for the childbirth and 95% enjoyed the classes being for men only. The qualitative analysis of open questions showed positive experiences.Conclusions: Attending specific antenatal classes for first-time fathers improves the experience of childbirth. Their experience reported in terms of sharing and solidarity seems to be meaningful. Offering fathers-to-be a specifically dedicated space for expression is a way to support their transition to fatherhood.
Identification of a Six-lncRNA Prognosis Model for Predicting Progression-Free Survival in Patients with Thyroid Cancer
Authors: Ji Pei , Xu Tingyu , Hu Yifang , Cui Dai , Wang Zhongmin
Published: February 2022

Background: Thyroid cancer is the most common malignant tumor of the endocrine system. Long non-coding RNAs (lncRNAs) have been demonstrated as novel biomarkers for cancer prognosis. Methods: In this study, we performed differential expression analysis of lncRNA expression profiles in GEO datasets. LASSO regression analysis was conducted to identify lncRNA-based prognosis model that can predict progression-free survival in thyroid cancer patients from The Cancer Genome Atlas (TCGA). Further functional analysis revealed the potential biological functions of the lncRNAs.Results: A risk score model based on six lncRNA biomarkers were established after LASSO Cox regression analysis. The prognostic value of the 6-lncRNA prognosis model was successfully validated and ROC curves was analysed. Patients were classified into high- and low-risk groups using the 6-lncRNA signature-based risk score. Patients in the low-risk group had significantly better progression-free survival than high-risk group. The result of multivariate analysis showed that the six-lncRNA signature was independent from clinical features such as age, gender and stage. GO and KEGG enrichment analysis and estimation of immune infiltration suggested that the lncRNAs might closely associated with tumorigenesis. Conclusion: Our study has constructed a novel six-lncRNA prognosis model to improve progression-free survival prediction in patients with thyroid cancer.