bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure and history of Hellenides
Authors: Argyriadis Ion , Forti Silvia
Published: June 2024

This study is based on some new field observations made on the group of the Eastern Hellenic regions. Our observations have led us to adopt a simplified view of the paleogeography of the Greek mainland before the Alpine orogenesis. The subsequent varied tectonic units originate mainly from the following paleogeographic areas:
• A carbonate Arabo-African shelf margin which displays several lateral transitions, ridges and basins. On the Greek mainland this margin is represented by the Preapulian, Ionian, Gavrovo-Tripolis, Parnassos zones, the Olympus platform and probably the Kavala and Thassos marble.
• A transition zone from the shelf units to the Tethys ophiolites (Pindos Zone, Styra, Argolis and Hydra, Eretrias new unit).
• Tethys ophiolites, which might represent either an “ocean” fault zone or subduction of the lithosphere along a weak area.
• A Hercynian continental mass (Serbomacedonian).
This group is currently completed by the presence of a large tectonic mélange connected to the ophiolite overthrust.
Structural data, geomorphology and rock slides in the SW of Barles (The Alps of Northern Provence, France)
Authors: Bureau Dominique
Published: June 2024

The Alps of northern Provence in France is a familiar area to European geologists because numerous, long field studies have been organized by European universities and private petroleum companies during the 20th century and the beginning of the 21st century. Nevertheless, geologists have made few comments on the consequences of some topographic slides and, more broadly, on the manner by which nature has sculpted the local geomorphology. After having set the local tectonic data (the thrust of the Blayeul Massif on an already folded para-autochtonous formation and locally up and down reversals in the area of the Heights of Chine and Proussier), a geological and geomorphological summary introduces a discussion on slides and slope formations; then the details of the morphology analysis lead us to the conclusions.
Over half a century of Messinian salinity crisis
Authors: Vai Gian Battista
Published: June 2024

Did the Mediterranean ever become a desert during Messinian or was it a huge hyperhaline water body? According to Selli, the introduction of the concept and name of the Messinian Salinity Crisis in 1954, the second hypothesis was correct, but he did not succeed in preventing the rapid growth of popularity of the first hypothesis, triggered by the DSD Mediterranean campaign during the 1970s. The ensuing desiccation theory became popular enough to be included in elementary text books.
The controversy has been revived in the new millennium and much former proof of the theory is now in doubt. The Mediterranean was not totally isolated, but often supplied with normal marine water. Instead of km-deep drawdown, shallower-to-absent level drop is favoured. Exposed canyons at the mouth of major Mediterranean rivers have turned into submarine channels filled by clastic sulphates. The mega-catastrophic potential of the desiccation theory has turned out to be less worrying. Perhaps the textbooks of our grandchildren should be updated.
Within the frame of new evidence regarding normal water supply, even from the Indian Ocean, are discussed, based on two new palinspastic Messinian maps. However, reduced sharpness in the controversy and increasing consensus reached among specialists depend on ongoing inferred correlations between on-land and deep-marine Messinian evaporites. Only drilling across the whole, deep Mediterranean evaporite sequences can back-up the reliability of the correlation and validity of these new views.
Histoplasmose disseminada em canino urbano com acesso ao ambiente rural
Authors: Vanzin Paula Michelson , Santos Ezequiel Davi dos , Silva Rúbia Schallenberger da , Pereira Bibiana da Rosa , Santos Aline Bielak dos , Motta Adriana Costa da
Published: June 2024

Histoplasmosis is a systemic disease caused by the fungus Histoplasma capsulatum. The microorganism causes localized granulomatous disease, with the respiratory tract being most affected, and can spread through the lymphatic and blood stream. Severe infection in dogs is associated with immunosuppressive therapies. The reported case occurred in a canine, brought to care with a serious clinical condition, which did not respond to treatment and was euthanized. The necropsy examination showed white nodules, of firm consistency and distributed throughout the omentum, liver, splenic capsule, pancreas, stomach serosa, intestines, bladder, mesenteric and inguinal lymph nodes, diaphragm, parietal pleura, aorta and aortic lunate. Microscopically, all nodular lesions consisted of areas of necrosis, with intense histiolymphoplasmacytic infiltrate, epithelioid macrophages and Langhans-type giant cells with yeast-like structures, with morphology and arrangement consistent with Histoplasma spp., confirmed by special Periodic Acid-Schiff (PAS) stains and Grocott. Therefore, the present study aims to describe a case of multisystemic histoplasmosis in a canine, diagnosed through anatomopathology and histochemistry, and to alert to this potential infection in urban canines with access to rural areas and/or environments with the fungal agent.
Parâmetros hematológicos da tainha (Mugil Liza) submetida a diferentes concentrações de formalina e água doce
Authors: Souza Ana Paula de , Brasil Elenice Martins , Pereira Scheila Anelise , Costa Domickson Silva , Lessa João Gabriel Miranda , Magnotti Caio Cesar França , Cerqueira Vinicius Ronzani , Martins Mauricio Laterça
Published: June 2024

Lebranche mullet, Mugil liza is a species of high economic value for fishing. Despite the importance of the species, little is known about the effects of therapeutic baths on the hematological parameters of mullet. Such parameters are important tools for facilitating the early detection of diseases and illnesses that may impair the performance of the animals. This study evaluated the hematological parameters of mullet submitted to therapeutic baths with formalin and freshwater. For the experiment a total of 108 mullets were used, divided in groups of six individuals per tank. In this experiment, immersion baths were tested for 1 hour in freshwater (zero salinity), formalin at concentrations: 150, 200, 250, 300 and 350 mg L-1 in seawater and a control (without formalin and parasitized), in triplicate. After the immersion bath, fish blood was collected from the caudal vein for evaluation of hematological parameters. The blood was destined to erythrogram, leukogram, thrombogram and glucose determinations. The hematological analyses found significant difference in the number of erythrocytes, lymphocytes, hematocrit, hemoglobin, MCV, MCH, MCHC and glucose. However, there was no significant difference in thrombocyte, total leukocyte, monocyte and neutrophil values. It is concluded that 150 mg L-1 formalin concentration and freshwater bath for one hour can be used for mullet as it causes mild hematological changes.
Ecocardiografia fetal nas modalidades B e M para padronização de variáveis cardiovasculares morfológicas e funcionais de fetos caninos no terço final da gestação: medidas ecocardiográficas fetais
Authors: Rodrigues Renan Paraguassu de Sá , Leitão Kelvin Ramon da Silva , Sousa Francisco das Chagas Araujo , Moura Laecio da Silva , Marques Danielle Clímaco , Alves Flavio Ribeiro
Published: June 2024

Fetal echocardiography allows early diagnosis of cardiovascular changes. However, few studies have described physiological values that allow a quantitative evaluation for this test in dogs. The objective was to describe the presumed physiological values of echocardiographic variables obtained in B and M modes, and cardiac function, by canine fetal echocardiography in the last trimester of pregnancy. Twenty fetuses were submitted to fetal echocardiography. The variables that showed a statistically significant correlation coefficient in relation to fetal age were the diameter of the aorta and the thickness of the interventricular septum in systole and in diastole. The morphological evaluation allowed the observation and determination that the heart occupied an average of one third of the thorax, most of it located in the left hemithorax and with the apex turned to the left. By identifying the spine, the anterior wall of the chest was observed opposite to it, represented by the sternum. The right ventricle was found just below, separated from the right atrium by the tricuspid valve. Both ventricles showed similar size, thickness and contractility. The measurement of ejection fractions and shortening allowed the determination of the left ventricular systolic function. This study determined physiological values for the main echocardiographic variables obtained in B and M modes for the investigated group.
Relato de caso de correção cirúrgica de estenose prepucial adquirida em bezerro
Authors: Câmara Antonio Carlos Lopes , Borges José Renato Junqueira
Published: June 2024

Diseases involving the reproductive tract of male ruminants, especially bulls, are a significant cause of economic and genetic loss to beef and dairy cattle industry worldwide. In calves, congenital hypospadia is the most commonly reported condition affecting genital organs. In the reviewed literature, there are no reports of surgical correction of acquired phimosis in calves. Therefore, the present paper aimed to report the surgical correction by circumcision of a traumatic-induced phimosis in a calf. A 6-months-old crossbred calf was submitted to surgical correction of acquired preputial stenosis by the Lazzeri circumcision approach. Surgery was uneventful and post-operatory complication was restricted to partial wound dehiscence, that did not compromise complete secondary intention healing. Long-term follow-up (30-months after surgery) was conducted by telephone call, revealing that the calf is now a bull with 3-years-old and still is the herd’s breeder. To the best of our knowledge, this is the first report of surgical correction by circumcision of a traumatic-induced phimosis in a calf using the Lazzeri technique. In this calf post-operatory complications were considered minor and long-term follow-up confirmed that the procedure was successful, and the animal obtained its reproductive capacity maintained.
Importance of Canis familiaris in the maintenance of visceral leishmaniasis in the endemic area of Diamantina municipality (Minas Gerais State, Brazil)
Authors: Antônio Nascimento Dória Diogo , Michalsky Monteiro Érika , Santos Dias Edelberto , Cotta Bodevan Emerson , Andrade Barata Ricardo
Published: June 2024

The present study aimed to evaluate the role of dogs in the epidemiology of visceral leishmaniasis (VL) in the municipality of Diamantina. Phenotypic information of seroreactive dogs were analysed and the identification of Leishmania was performed by Ln-PCR and sequencing. The predominant profiles observed were dogs residing in the rural area, males, mongrel and short-haired dogs. The most clinical signs were onychogryphosis and cachexia. The presence of Leishmania infantum circulating in the dogs of the municipality is worrying and indicates that urgent measures for surveillance and control of VL should be adopted in this endemic area.
Targeted Treatment of Various Cancers using Radionuclide: Advancement and Prospective
Authors: Rajput Shivam , Malviya Rishabha , Srivastava Saurabh , Ahmad Irfan , Obaidur Rab Safia , Uniyal Prerna
Published: June 2024

Radiopharmaceutical therapy is a novel targeted cancer treatment approach that is presently
being investigated and developed. Radiation is administered in radiopharmaceutical therapy by
selectively binding drugs to target cancer cells. Since most radioactive materials used in radiation
therapy emit photons, it is possible to monitor the movement of drugs in a non-invasive manner.
Compared to other systemic cancer treatments, Radiopharmaceutical therapy has shown effectiveness
with minimal adverse effects. Radiopharmaceutical treatment has shown a promising safety profile
and potential effectiveness against various types of cancers. Additionally, it has been successful in
distinguishing between cancerous and non-cancerous tissues. Radiopharmaceutical therapy offers
numerous advantages compared to other techniques. Radiopharmaceuticals are chemical substances
containing a radioactive isotope that can release radiation. This radiation can be identified and employed
for medical imaging or as a therapy for cancer. Several cancer treatment methods utilize radiopharmaceuticals,
such as radioimmunotherapy, radiolabeled peptides, radiolabeled small molecules,
bone-targeted radiopharmaceuticals, and others. This review aims to comprehensively analyze the
fundamental principles, recent advancements in clinical practice, and an in-depth understanding of
radiotherapy in cancer management.
Precision Medicine in Fibromyalgia Syndrome
Authors: Fatima Ghizal
Published: June 2024

Individualized remedy for patients is a middle objective of today’s clinical
approach and the need of our society. Many elements, starting from genes to proteins,
all stay unknown for their unique roles in human physiology. The accurate prognosis,
monitoring, and remedy of various problems require dependable biomarkers, for the
development of correct healing interventions. Precision medicine within the treatment
of Fibromyalgia Syndrome (FMS) has attracted a whole lot of attention, particularly
with the gene discovery pushing toward more modern know-how of the biology of
disorders. Genome-huge association research has proven that in fibromyalgia
pathogenesis, genetic factors are accountable for as much as 50% of the sickness
susceptibility. Candidate genes determined to be associated with fibromyalgia are
SLC64A4, TRPV2, MYT1L, and NRXN3. Fibromyalgia is an extensive
musculoskeletal pain disorder followed by fatigue, sleep, memory, and mood troubles. Fibromyalgia syndrome (FMS) exacerbates painful sensations by altering the way the
brain and spinal cord process both painful and non-painful signals. While some
targeted treatments have shown promise in improving the condition of FMS patients in
the short term, there is an opportunity to delve deeper into the mechanisms at play.
With the aid of animal models, we can further explore the intricate interplay between
the brain and the spinal cord, identifying specific genes, loci, and potential failures
within the spinal cord that contribute to FMS.
Additionally, FMS has been linked to biogenic amine depletion and mitochondrial
dysfunction. These factors represent crucial avenues for investigation. This chapter
aims to spotlight the significant advancements in technology that facilitate personalized
or precision medicine approaches for FMS. Since FMS is closely tied to the
functioning of the brain and spinal cord, research using animal models offers a
promising avenue, as conducting experiments on patients presents logistical challenges.
Therapeutic Dynamics of Tannin Interaction and Significance in Precision Medicine
Authors: Khan Mohammad Faheem , Ansari Waseem Ahmad , Ali Kajim
Published: June 2024

Personalized medicine is a targeted therapy that aims to provide people
suffering from complex illnesses with tailored-made healthcare. Taking this into
consideration, foods with diverse bioactive compounds have recently gained
widespread scientific interest as alternatives to modern drugs for developing
therapeutic agents against human diseases. Tannins are an important group of
polyphenol compounds in foods that have both beneficial and anti-nutritional effects.
As an anti-nutrient, they can reduce element bioavailability, and protein absorption,
and inhibit enzymatic actions during metabolism. If tannin-rich foods are consumed in
sufficient quantities and at the appropriate time, they may act similarly to natural drugs
that ameliorate a range of metabolic disorders. Thus, the types of tannin-rich foods and
the timing of consumption before or after meals should be considered for maximum
physiological importance in maintaining human health. In this chapter, we compiled
the different types of tannins and their food sources, as well as their beneficial and antinutrient effects on human health.
Analisis Pelaksanaan Pengadaan Tanah untuk Pembangunan Jalan Lingkar Timur di Kabupaten Sukoharjo Jawa Tengah
Authors: Rahmawaty Mitha Asyita , Mispaki Syachril Warasambi , Alfiah Eva Nur
Published: June 2024

Permasalahan yang dihadapi oleh pemerintah dalam pelaksanaan pembangunan itu sendiri dikarenakan tanah negara yang saat ini jumlahnya sangat terbatas. Sebagai kabupaten yang menghubungkan antar pusat industri dan perdagangan, kondisi kemacetan di Kabupaten Sukoharjo perlu penanganan serius baik melalui peningkatan kualitas dan kapasitas jaringan jalan. Kabupaten Sukoharjo menjadi salah satu tempat berlangsungya proyek pembangunan jalan yaitu Jalan Lingkar Timur (JLT) segmen Plesan-Bendosari. Penelitian ini mengeksplorasi obyek penelitian dengan studi literatur dan pendekatan spasial yang bertujuan untuk menjelaskan mekanisme dan penyelesaian ganti kerugian atas hak atas tanah serta hambatan yang timbul dalam pembangunan Jalur Lingkar Timur Kabupaten Sukoharjo. Dalam melakukan penelitian ini penulis mengumpulkan sumber data dipadukan dengan teori hukum yang ada didukung studi kepustakaan yang dianalisis secara sistematis dan konseptual terkait dengan proses pengadaan untuk pembangunan Jalan Lingkar Timur di Kabupaten Sukoharjo. Pelaksanaan pengadaan tanah Pembangunan Jalan Lingkar sudah dilaksanakan sejak tahun 2015 hingga selesai tahap penyerahan hasil pada tahun 2020. Tahap akhir dari pelaksanaan pengadaan tanah sendiri yang berupa penyerahan hasil terjadi pada bulan Desember 2020, kemudian agenda kedua pada bulan Maret-April 2021. Kendala yang terjadi dapat terselesaikan dengan cukup baik dengan upaya pemerintah walaupun terkendala kondisi pandemi covid-19 dan beberapa kendala yang biasa muncul selama tahap penyelesaian dari kegiatan pembangunan.
Pengelolaan sampah dan partisipasi masyarakat terhadap sampah rumah tangga di RW 06 percontohan pengurangan sampah Kelurahan Kebon Kosong, Jakarta Pusat
Authors: Pratiwi Shafira Adelia
Published: June 2024

Penelitian ini bertujuan untuk mengetahui sistem pengelolaan sampah dan bentuk partisipasi masyarakat di RW 06 yang didaulat menjadi RW percontohan pengurangan sampah, sebagai bagian dari program SAMTAMA dalam melakukan pengelolaan sampah yang berbasis 3R. Penelitian ini dilakukan di RW 06 Percontohan, Kelurahan Kebon Kosong, Jakarta Pusat. Metode yang digunakan dalam penelitian ini adalah metode deskriptif evaluatif. Hasil penelitian ini menunjukkan bahwa RW 06 menerapkan tiga sistem pengelolaan sampah yaitu, pengelolaan sampah dengan tabungan bank sampah, mandiri dan produktif serta kumpul-angkut-buang. Masyarakat RW 06 sudah mulai berpartisipasi dalam pengelolaan sampah secara 3R, seperti dalam tahap perencanaan mengikuti kegiatan rapat pengelolaan sampah secara 3R, pada tahap pelaksanaan sudah melakukan pemilahan sampah organik dan anorganik, kegiatan-kegiatan yang dapat mengurangi sampah (3R), lalu pada tahap evaluasi masyarakat RW 06 sudah terlibat dalam pemantauan dan pemberian kritik/saran terhadap pengelolaan sampah secara 3R. Meskipun beberapa masyarakat sudah berpartisipasi untuk mengupayakan pengelolaan sampahnya secara 3R, sistem pengelolaan sampah masih dominan digunakan masyarakat RW 06 percontohan pengurangan sampah.
Identifikasi Kerentanan Masyarakat Usia Produktif terhadap Penyebaran Vuirus Covid-19 di Kecamatan Mlati Kabupaten Sleman Daerah Istimewa Yogyakarta
Authors: Suherningtyas Ika Afianita
Published: June 2024

Tujuan penelitian ini adalah mengidentifikasi hubungan kerentanan masyarakat usia produktif terhadap penyebaran virus covid-19 di (daerah peri- urban) Kecamatan Mlati. Kecamatan Mlati merupakan daerah peri-urban yang memiliki tingkat penularan covid-19 yang terus mengalami kenaikan kasus pada masyarakat usia produktif. Metode untuk mengetahui kerentanan yang terjadi dilakukan dengan deskriptif kuantitatif, pengambilan sampel dengan teknik stratified random sampling pada lima desa yang berada di Kecamatan Mlati menggunakan kuesioner. Pembobotan pada tiap parameter berupa aktivitas keseharian yang dilakukan oleh masyarakat dengan Analytical Hierarchy Process (AHP). Identifikasi kerentanan masyarakat usia produktif terhadap penyebaran virus covid-19 menggunakan sifat statistik korelasi chi square untuk mengetahui hubungan pada parameter. Berdasarkan uji statistik chi square parameter penelitian menunjukan lima parameter yang memiliki hubungan dengan parameter yang mempengaruhi antara lain mobilitas, riwayat penyakit, aktivitas organisasi, jenis pekerjaan dan pendapatan perbulan. Hasil penelitian menunjukan pada peta kerentanan pada Kecamatan Mlati paling tinggi berada di Desa Sinduadi, sedangkan Desa Sendangadi, Desa Tlogoadi, Desa Sumberadi dan Desa Tirtoadi memiliki kerentanan sedang.
Relevansi fenomena lingkungan kawasan borobudur sebagai sumber belajar geografi
Authors: Widodo Edi , Rifa'atussa’adah Nahida , Riantika Rasti Fajar Peni , Masruri Muhsinatun Siasah , Hastuti Hastuti
Published: June 2024

Keunikan candi dan fenomena lingkungan kawasan sekitar Borobudur dapat dijadikan sumber belajar geografi. Tujuan penelitian untuk mendeskripsikan fenomena lingkungan di kawasan sekitar Borobudur untuk dapat dimanfaatkan sebagai sumber belajar geografi. Teknik pengumpulan data meliputi pengamatan lapangan, wawancara mendalam terhadap responden kunci, dan selanjutnya dokumentasi. Validasi data menggunakan trianggulasi teknik menurut Miles dan Huberman. Hasil penelitian menunjukkan terdapat keunikan fenomena lingkungan yang ada pada kawasan sekitar candi Borobudur layak digunakan sebagai sumber pembelajaran geografi secara kontekstual pada jenjang sekolah menegah atas. Hasil kajian menatakan relevansi fenomena tersebut dapat digunakan untuk sumber belajar geografi sekolah menengah atas pada materi pembelajaan sistem informasi geografis, hidrosfer, kebencanaan, penginderaan jauh dan litosfer. Pengembangan Candi Borobudur sebagai prioritas wisata Dunia, diharapkan memperhatikan nilai edukatif yang terkandung di dalamnya supaya fenomena lingkungan yang dapat dijadikan sumber belajar tidak hilang.
Pengaruh Lereng dalam Penentuan Kesesuaian Permukiman di Bogor Raya
Authors: Gafuraningtyas Dewi , Wibowo Adi
Published: June 2024

Meningkatnya jumlah penduduk maka mengakibatkan meningkatnya aktivitas antropogenik pada suatu wilayah. Salah satu permasalahan utama yang muncul seiring dengan perubahan aktivitas manusia adalah meningkatnya kebutuhan akan perumahan atau permukiman. Penduduk seringkali membangun tempat tinggal pada lahan yang tidak sesuai akibat semakin sempitnya lahan kosong yang dapat dijadikan area terbangun. Hal ini mengakibatkan maraknya penggunaan lahan di wilayah dengan kemiringan lereng di atas 20% sebagai lokasi untuk tempat tinggal. Bogor raya yang mencakup Kabupaten Bogor dan Kota Bogor merupakan wilayah yang mengalami pesatnya pertumbuhan permukiman dalam beberapa tahun terakhir. Oleh sebab itu, rencana tata ruang menjadi kontrol penting dalam mencegah adanya dampak  negatif dari pertumbuhan permukiman. Penelitian ini bertujuan untuk mengevaluasi rencana tata ruang pada pola kawasan permukiman terhadap kelerengan. Metode yang digunakan adalah overlay antara data DEMNAS dengan data spasial RTRW. Hasilnya menunjukkan bahwa di Kabupaten Bogor kesesuaian penetapan permukiman dengan kondisi kelerengan 25% mencapai 97,7% sedangkan pada Kota Bogor kesesuaiannya mencapai 99,17%.
Perkembangan Lahan Terbangun Kota Pekanbaru Tahun 2000-2020
Authors: Almegi Almegi , Fatmawati Fatmawati
Published: June 2024

This research aims describe the development of built-up area and identify trends the development of built-up area in Pekanbaru City in 2000-2020. The approach in research is descriptive quantitative with stages of temporal landsat image interpretation, field verification, and spatial analysis. The study population is the entire pixel data in satellite imagery with sampling techniques for the image interpretation process. Supervised classification is used in the interpretation process, kappa index with 22 sample points is used to test the accuracy of the interpretation results, and map overlays are used in spatial analysis. The results of the analysis show that in the last two decades (2000-2020) the built-up area in Pekanbaru City increased by 13,45% (85,99 km2) with an average increase of 0.67% (4,30 km2) annually. Spatially, the distribution of development of built up area is unevenly, but forms a patterns and directions that tends to be the same, namely the pattern of spreading from the city center to the fringe area with development trends in the south and southwest following the main road route.
Spin Entanglement – A Unifying Principle for Superconductors and Molecular Bonding
Authors: O'Hara Paul
Published: June 2024

The spin-statistics theorem is generalized to include quantum entanglement. Specifically, within the context of spin entanglement, we prove that isotropically spin-correlated (ISC) states must occur in pairs. This pairing process can be composed of parallel or anti-parallel states. Consequently, the article proposes using ISC states as a unifying principle to explain better Bose-Einstein condensates, the theory of superconductivity, and molecular and atomic orbitals, all of which involve a pairing process. The theoretical framework is established in sections 1 and 2. The other qualitative sections focus primarily on the experimental evidence to support the theory.KeywordsEntanglement and spin-statistics; unifying principle; condensates; superconductors; molecular bonds
Current Management of CINV (Preprint)
Authors: Mahendra I Nyoman Bayu
Published: June 2024

BACKGROUND

Chemotherapy-induced nausea and vomiting (CINV) significantly impact cancer patients undergoing treatment, affecting their quality of life and treatment adherence. Despite advances in antiemetic therapy, CINV remains a challenge, necessitating ongoing research and development of effective management strategies.

OBJECTIVE

This review aims to provide an overview of the current management strategies for CINV, focusing on the use of 5-HT3 receptor antagonists, NK1 receptor antagonists, corticosteroids, and newer agents like olanzapine. The review also discusses risk factors for CINV and the pathophysiology underlying its various forms.

METHODS

A comprehensive literature search was conducted to identify relevant studies and guidelines related to the management of CINV. Key databases, including PubMed, were searched for articles published in English. Studies evaluating the efficacy and safety of antiemetic agents in preventing and treating CINV were included in the review.

RESULTS

The review highlights the importance of risk assessment for CINV based on patient and chemotherapy-related factors. It discusses the role of 5-HT3 receptor antagonists, NK1 receptor antagonists, and corticosteroids in the prevention and treatment of CINV, emphasizing the need for individualized therapy. The review also discusses newer agents like olanzapine and their potential in improving CINV control.

CONCLUSIONS

Effective management of CINV is crucial for optimizing cancer treatment outcomes and improving patient quality of life. A multimodal approach combining different classes of antiemetic agents tailored to individual patient risk factors and chemotherapy regimens is recommended. Ongoing research is needed to further improve the management of CINV and reduce its impact on cancer patients undergoing treatment.
Design, Development, and Evaluation of escape rooms in medical education: Protocol for a Scoping Review (Preprint)
Authors: Krage Ralf
Published: June 2024

BACKGROUND

Serious games encompass a wide range of educational approaches, including e-learning, edutainment, game-based learning, and digital game-based learning. These games align with the digitalization of education and offer innovative opportunities for learning and assessment in medical education. Among these serious games, escape rooms stand out as they combine mental and physical challenges to enhance critical skills relevant to everyday life. They foster logical thinking, require careful analysis of situations, and demand problem-solving abilities within the constraints of time and pressure. Additionally, escape rooms provide a suitable environment for developing communication, leadership, and problem-solving skills through collaborative efforts towards a shared objective. This study aimed to explore the various applications of escape rooms in the context of medical education.This scoping review aims to help inform those who wish to develop effective escape rooms interventions.

OBJECTIVE

In this review, the development, design, and assessment of escape rooms in medical education are examined. Studies examining escape rooms in medical education are the main focus of this article, which aims to pinpoint important aspects of their conception, implementation, and assessment.

METHODS

This scoping review will adhere to the Joanna Briggs Institute's methodology, ensuring standardized conduct and reporting. The search strategy involves three steps: identifying terms and keywords, conducting a systematic search across selected databases, and examining reference lists for additional material. The databases used include MEDLINE, PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and ProQuest Dissertations and Theses. The review aims to follow predefined inclusion criteria and will document any modifications made to the search strings. The review's methodology and search strategy aim to promote consistency and comprehensiveness in identifying relevant literature.

RESULTS

The data collected in this systematic scoping review on escape rooms in medical education will be presented in diagrammatic or tabular formats, complemented by a narrative summary. The report will be structured into two sections: the selection process with a PRISMA flowchart, and the results addressing the review questions. The aim is to provide comprehensive and visually supported findings in a scoping review report.

CONCLUSIONS

This review will help guide scholars looking to build escape rooms interventions toward evidence-based practices in design and evaluation.
Effects of Konjac (Amorphophallus muelleri Blume) Flour Addition and Drying Time on the Crude Fiber and Texture Level of Instant Yellow Rice
Authors: Anam Choiroel , Zulfa Fitriyah , Suleman Dininurilmi Putri , Abdi Yenny Febriana Ramadhan , Mulyani Rizka , Rochmah Alfi Nur , Adi Prakoso , Rahmawati Adinda Dwi
Published: June 2024

Instant yellow rice is a traditional breakfast dish prepared using special technology for quick and practical cooking and a longer shelf life. Since rice has low crude fiber content as the main ingredient, substitution with local sources, such as konjac flour, can be made. Konjac flour is the powdered root of konjac plant, and it contains high crude fiber. Therefore, this study aimed to examine the texture and crude fiber properties of instant yellow rice with the addition of konjac flour. Furthermore, a completely randomized design (CRD) was used with two factors, namely variations in konjac flour concentration (2%, 3%, and 4%) and variations in drying time (5 hours, 6 hours, and 7 hours). Each sample was analyzed for the physical (hardness, stickiness and chewiness texture) and chemical characteristics (crude fiber content). The results showed that the konjac flour concentration had a significant (p<0.05) effect, while the drying time had no significant (p<0.05) effect on the physical and chemical characteristics of instant yellow rice. Therefore, 5 hours of drying might be enough for the rice processing. The addition of 2% konjac flour on instant yellow rice dried for 5 hours showed 2.48±0.50 a N of hardness texture, 5.53±0.07 c N stickiness texture, 4.59±0.02 a N chewiness texture, and 5.20% of crude fiber. Addition of 3% konjac flour on instant yellow rice dried for 5 hours showed 5.74±0.08 b N of hardness texture, 4.73±0.17 b N stickiness texture, 4.37±0.05 a N chewiness texture, and 5.20% of crude fiber. The addition of 4% konjac flour on instant yellow rice dried for 5 hours showed 6.41±0,02 c N of hardness texture, 4.06±0.70 b N stickiness texture, 3.33±1.52 a N chewiness texture, and 5.35% crude fiber. This showed the best treatment was the use of instant yellow rice with 4% konjac flour addition at 5 hours drying time.
Optimization of Sorghum Starch (Sorghum bicolor L.) Partial Hydrolysis using Microwave-Assisted Acetic Acid Catalyst
Authors: Sitio Septi Enjelina , Nurlaili Fitri Dwi , Riadhus Shalihin Muhammad Zaki , Amalia Rizka , Paramita Vita
Published: June 2024

Hydrolysis process is relatively slow, requiring the use of catalyst and microwave assistance to accelerate the reaction. There fore, this study aimed to determine the optimum conditions for partial hydrolysis of sorghum starch (Sorghum bicolor L.) using acetic acid as a microwave-assisted catalyst to produce maltodextrin. The experiment was carried out in several stages, namely gelatinization, liquefaction, and drying, while Response Surface Method (RSM) was used for variable design and data analysis. Hydrolysis process was carried out with three independent variables, including acetic acid concentration (9%, 12%, and 15%), microwave power (300 watts, 400 watts, and 500 watts), and liquefaction time (35 minutes, 45 minutes, and 55 minutes). The results showed that the highest DE (Dextrose Equivalent) value of maltodextrin was found at 17.04% acid concentration, 400 watts microwave power, and 45 minutes liquefaction time, valued at 18.921 ± 0.099. The optimum dextrose equivalent of 17.763 would be achieved at 16.879% acetic acid concentration, 390.233 watts of microwave power, and 47.055 minutes of liquefaction time. This study introduces the innovation of using acetic acid as a catalyst and microwave assistance during the gelatinization stage.
The Effect of Drying Method on The Quality of MOCAF (Modified Cassava Flour) from Raw Material Beta-Carotene-Rich Bokor Genotype Cassava
Authors: Aprilia Aqsha Putri , Fathoni Rois , Fathoni Ahmad , Setiarto Raden Haryo Bimo , Damayanti Ema
Published: June 2024

The high dependence on flour imports is a significant challenge to overcome by processing local food ingredients through diversification. To address this challenge, the use of MOCAF (Modified Cassava Flour) as a substitute for wheat flour has been carried out in the manufacture of wet and dry noodles, along with analog rice, and bread. The optimization of MOCAF production from beta-carotene-rich cassava depends on the selection of appropriate equipment technology and drying process. Therefore, this study aimed to analyze the effect of drying method on MOCAF characteristics of beta-carotene-rich cassava genotype. The analysis was carried out using two methods, namely sun drying for 3-4 days and oven drying at 60 o C for 24 hours. Parameters analyzed included viscosity, solubility, syneresis, Near Infra-Red analysis, proximate analysis, and Scanning Electron Microscope (SEM). The results showed that drying affected the physicochemical properties of MOCAF, including viscosity, solubility, and syneresis. NIR (Near-infrared) and proximate analysis showed that drying process affected the decrease in moisture, ash, protein, and fat content, along with an increase in crude fiber, and dry fiber matter content. Furthermore, SEM microstructural analysis resulted in the reformation of starch granules, characterized by changes in morphology and structure, such as the separation of irregular spherical shapes, and hollowness.
Production of Fatty Acid Methyl Ester Surfactants using Palm Oil with Various Reaction Temperatures and Duration
Authors: Agatha Stefanie Bernike , Ariviani Setyaningrum , Yuliatun Simping
Published: June 2024

Most surfactants are made from petrochemicals, posing significant environmental concerns due to the non- biodegradable and non-renewable nature. To address this challenge, surfactants from biodegradable, non-toxic, and harmless materials are required, such as Fatty Acid Methyl Ester (FAME) derived from palm oil. Therefore, this research aimed to investigate the effect of reaction tempetarures and durations as well as the interactions on the yield of FAME surfactants. The characteristics of the highest yield of FAME surfactants were also examined, including HLB (hydrophilic-lipophilic balance) value, surface tension, CMC (critical micelles concentration), density, and pH values. The study was conducted using Completely Randomized Factorial Design with three (3) factors, namely temperature (50 and 60 °C), reaction duration (60, 90, and 120 minutes), and the interaction. The results showed that the highest yield of 82.43% was produced at an interaction reaction temperature of 60 °C and a duration of 120 minutes. The characteristics of surfactants obtained were HLB value of 5.47, surface tension of 30.49 dyne/cm, capable of reducing surface tension by 73.20% (from 72.80 to 19.52 dyne/cm), CMC, density and pH values of 1.50% (v/v), 0.8757 g/cm 3 , and 6.86, respectively. These characteristics suggested that FAME has the potential for application as a water-in-oil (w/o) emulsifier. Moreover, the results could be applied to produce biodegradable surfactants using tropical oils through easy and simple technology.
New Series of Ni(II), Cu(II), Zr(IV), Ag(I), and Cd(II) Complexes of Trimethoprim and Diamine Ligands: Synthesis, Characterization, and Biological Studies
Authors: Al-Assafe Amaal Younis , Al-Quaba Rana Abdul Malik Sulaiman
Published: June 2024

New compounds series of [M(TMP)(en)]X·nH2O and [M(TMP)(PD)]X·nH2O, where M = Ni2+, Cu2+, Zr4+, Ag+, Cd2+, TMP = trimethoprim, en = ethylenediamine, PD = o-phenylene and X= Cl− or NO3−, were prepared. The compounds were characterized using techniques including melting points, conductance, elemental analysis, FTIR, NMR, and mass spectroscopy. FTIR spectra indicated TMP acted like a bi-dentate ligand, combining via the nitrogen atoms of azomethine and pyrimidine amino groups. Diamine ligands (en or o-PD) are coordinated via two nitrogen atoms. Prepared compounds showed monomeric behavior and adopted a 6-coordinate octahedral geometry based on magnetic susceptibility and UV spectra. Conductivity measurements revealed Zr(IV) compounds were 1:2 conductive, while Ag+ and Cd2+ were 1:1 conductive; Ni2+ and Cu2+ compounds were non-conductive. Antibacterial tests on compounds and ligands against Bacillus subtilis and Staphylococcus aureus demonstrated broad-spectrum antibacterial activity. The mixed metal compounds revealed an observable tendency of antibacterial activity in the order Zr > Cd = Ag > Cu, making Zr(IV) compounds the most biologically active among them against S. aureus (Gram-positive) while the same compounds showed less antibacterial activity against B. subtilis (Gram-negative) than the free ligand.
Synthesis and Characterization of Novel Terpolymers as Viscosity Index Improvers Using Industrial Waste for Iraqi Lubricating Oil
Authors: AL-Malki Ziyad Tarik , Khalaf Moayad Naeem
Published: June 2024

The potential utilization of industrial waste, specifically polyethylene wax, to enhance the efficiency of alkyl acrylate polymers as viscosity index improver (VII) additives in lubricating compositions has been investigated. Four terpolymers (w1, w2, w3, and w4) were synthesized via free radical polymerization, incorporating hexyl acrylate, 1-tetradecene, and industrial waste-sourced polyethylene wax at varying molar ratios. These terpolymers were characterized through gel permeation chromatography (GPC) for molecular weight determination, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR) spectroscopy for chemical structure analysis, and thermal gravimetric analysis (TGA) for thermal stability assessment. The study evaluated the efficiency of these terpolymers as viscosity index improvers (VII) in combination with free additives Iraqi lubricating oil (base oil 60). Our results demonstrate the feasibility of significantly enhancing the efficiency of viscosity improvers through the utilization of industrial waste, with improvements proportional to terpolymer concentration. The terpolymer w3, characterized by a balanced molar ratio of 1:1:1, exhibiting the highest degree of efficacy, which gave VI of 206 at 5 wt.% concentration compared with free additive lubricating oil, which gives VI of 98. This study offers promising insights into the sustainable use of industrial waste to improve lubricating compositions.
In Silico Study of Aptamer Specificity for Detection of Insulin as Development for Diabetes Mellitus Diagnosis
Authors: Mulyani Dinda Exelsa , Maksum Iman Permana , Yusuf Muhammad
Published: June 2024

Diabetes mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels. There are 2 types of DM where molecular-level diagnosis becomes very important because both have different treatments to avoid treatment errors. An electrochemical aptasensor as a type 2 DM detector with insulin target has been developed. This study aims to determine the interaction and specificity based on the values of RMSD, RMSF, and binding energy between aptamer and insulin when it reaches stability in silico compared to HbA1c and glucose. Docking simulations were performed on the HDOCK webserver and dynamics simulations for 1000 ns on the aptamer and protein molecular models used. The simulation results were analyzed to see the stability and visualized using VMD to see the conformation of the aptamer-ligand complex. The docking result showed higher binding energy between aptamer-insulin compared to other molecules, namely −221.87 kcal/mol. The results of RMSF and RMSD analysis of molecular dynamics simulations show that the system is stable, has the best binding energy value of −9.9510 kcal/mol. The aptamer complex with insulin showed better specificity compared to glucose and HbA1c based on RMSD, RMSF, and binding energy.
Strategi Pengembangan Website Marketplace “Kiose Pejawaran” dalam Mendukung Digitalisasi Pemasaran Komoditas Pertanian di Kecamatan Pejawaran (Studi Kasus Desa Karangsari dan Desa Sarwodadi)
Authors: Sentagi Sesotya Utami  , Salsabila Aulia Rahmadani  , Linda Tri Nurjannah  , Vallentina Wahyu Febrihartanti  , Imam Arif Hadi Pramono  , Agatha Harta Muliani  , Bagas Yodya Ananda  , Muhammad Alwi Rahmanda
Published: June 2024

Pemasaran mempunyai peranan penting dalam siklus bisnis komoditas pertanian dan menentukan besar kecilnya pendapatan petani. Permasalahan pemasaran yang berada di Desa Karangsari dan Sarwodadi, Kecamatan Pejawaran yaitu terbatasnya akses promosi hasil panen dari petani serta rendahnya informasi komoditas siap panen bagi tengkulak. Kondisi ini membuat diperlukannya pemasaran online berbasis website untuk mengatasi permasalahan tersebut. Melalui website, petani dapat dengan mudah mempromosikan hasil panen dan menginformasikan status ketersediaan panen, sedangkan tengkulak dapat dengan mudah menentukan pembelian berdasarkan kuantitas yang dibutuhkan. Adapun tujuan yang hendak dicapai dari kegiatan pembelajaran dan pengabdian masyarakat ini yaitu 1) mengetahui kondisi permasalahan pemasaran komoditas hasil pertanian dari sudut pandang petani dan aktor pemasaran di Kecamatan Pejawaran; 2) mengetahui dan mengevaluasi usability website marketplace “Kiose Pejawaran”; dan 3) mengetahui dan merumuskan strategi pengembangan website marketplace “Kiose Pejawaran” dengan menggunakan analisis SWOT. Pengabdian dilakukan dengan metode pengambilan data melalui wawancara serta pelatihan berbasis Forum Group Discussion (FGD). Lebih lanjut, metode pengujian menggunakan System Usability Scale (SUS) dengan 10 pertanyaan sebagai tolak ukur kinerja website serta matriks SWOT untuk merumuskan strategi pengembangan. Dari hasil pengujian SUS, didapatkan skor akhir sebesar 57,875 yang termasuk dalam rating OK, tetapi menunjukkan pentingnya dilakukan perbaikan dan pengembangan untuk meningkatkan kesesuaian. Beberapa elemen perbaikan dan pengembangan dijelaskan secara rinci dalam matriks SWOT. Oleh karena itu, website marketplace “Kiose Pejawaran” sudah dapat digunakan dengan baik dan memerlukan keberlanjutan pemeliharaan dan pengembangannya.
Pariwisata Berbasis Komunitas sebagai Penggerak Sosial-Ekonomi Masyarakat Lokal: Strategi Pembangunan Ekowisata Bahari di Pulau Liki, Papua
Authors: R. Rachmat A. Sriwijaya  , Chalfi Laroza Virginindya Sutanto  , Muhammad Fauzan Ramadhani  , Syifaa Aqilla Hafidz
Published: June 2024

Pulau Liki merupakan salah satu pulau terluar di Indonesia yang terletak di Papua, Kabupaten Sarmi, Provinsi Papua. Sebagai pulau yang terletak di tengah Samudera Pasifik, Pulau Liki memiliki kekayaan alam tak ternilai khususnya keindahan alam baharinya yang berpotensi besar sebagai sebuah destinasi wisata yang menjanjikan. Meskipun memiliki keindahan alam yang tidak ternilai, Pulau Liki menghadapi tantangan ketimpangan, kemiskinan, dan ketertinggalan. Artikelini bertujuan untuk mengidentifikasi persiapan yang diperlukan untuk mewujudkan pariwisata bahari berkelanjutan di Pulau Liki dengan mengimplementasikan Community Based Tourism (CBT).   Model ini terbukti berhasil dalam mengembangkan pariwisata berkelanjutan di berbagai negara dengan berfokus pada partisipasi komunitas lokal dalam pengambilan keputusan dan pelestarian lingkungan. Artikel ini menganalisis keberhasilan peran komunitas dalam pengembangan pariwisata di daerah terpencil yang dampaknya dirasakan oleh penduduk setempat. Penelitian ini menggunakan metode kualitatif melalui observasi intensif serta pelaksanaan Focus Group Discussion (FGD) untuk mendapat perspektif lokal terkait pembangunan daerah berbasis pariwisata dan proyeksi CBT sebagai konsep pembangunan pariwisata berkelanjutan di Pulau Liki. Hasil penelitian ini menunjukkan bahwa konsep CBT sangat relevan untuk Pulau Liki karena dapat  berpotensi untuk meningkatkan kesejahteraan masyarakat setempat, melindungi keanekaragaman hayati, menggerakkan pertumbuhan ekonomi melalui Pendapatan Asli Daerah (PAD), serta pembangunan infrastruktur.
Melacak Minat Siswa SMP Negeri 2 Kismantoro dalam Melanjutkan Pendidikan
Authors: Purwanta  , Anirotun Nisa  , Reni Ramadhina  , Lestari  , Ahmad Sidik Pramono  , Defa Rizky Pratama  , Christy Paramitha  , Muhammad Fakhrizal
Published: June 2024

Ada beberapa faktor yang mempengaruhi minat anak untuk melanjutkan pendidikan ke jenjang lebih tinggi, termasuk potensi diri. Sayangnya, banyak siswa yang tidak tahu potensi diri mereka sendiri, dan ini berpengaruh pada motivasi mereka dalam menentukan pilihan pendidikan selanjutnya. Terbatasnya informasi dan jarak sekolah dapat mempengaruhi pilihan siswa SMP Negeri 2 Kismantoro dalam melanjutkan pendidikan. Penelitian ini dilakukan dalam program KKN-PPM UGM Periode 2 2023 di Kecamatan Kismantoro, Kabupaten Wonogiri. Ini untuk menggali faktor-faktor yang mempengaruhi motivasi siswa melanjutkan pendidikan ke jenjang lebih tinggi. Kegiatan terbagi menjadi tahap asesmen pra-konsultasi dan tahap konsultasi. Metode analisis data yang digunakan adalah analisis data deskripsi kualitatif. Berdasarkan konsultasi dengan 21 siswa kelas IX SMP Negeri Kismantoro, ternyata ada beberapa penyebab siswa tidak melanjutkan pendidikan. Ini disebabkan oleh kendala mobilisasi, terutama bagi siswa yang jarak sekolahnya jauh dan tidak memiliki kendaraan pribadi. Selain itu, sebagian besar siswa juga belum menyadari potensi diri mereka. Oleh karena itu, sekolah diharapkan dapat membantu siswa mengenali potensi mereka melalui tes minat dan bakat serta bimbingan dan konseling.  Asesmen dan konsultasi yang dilakukan dapat memberikan masukan untuk sekolah mengatasi masalah siswa putus sekolah dan membutuhkan bantuan pihak lain untuk mendampingi siswa demi kelangsungan program ini.