bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic
Review
Authors: Ghaderi Mohammad Amin , Emami Seyed Ahmad , Beirak Olia Mahla Daliri , Javadi Behjat
Published: May 2022

Background:

Neurodegenerative Diseases (NDs) are characterized by progressive neuronal
deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with
multitarget activities, have been studied widely.

Objective:

In this review, we aim to survey the neuroprotective effects of sesamin on NDs and its
mechanisms of action.

Methods:

Searching GoogleScholar, PubMed, and Science Direct databases, we reviewed original
English language articles on sesamin effects against NDs, specifically Alzheimer’s Disease (AD) and
Parkinson's Disease (PD), either in vivo or in vitro settings, with no time limitation.

Results:

Sesamin has been reported to interfere with NDs progression through its antioxidative, antiinflammatory,
and antiapoptotic actions in most of the retrieved studies. Sesamin also can prevent
amyloid-β aggregation in AD models and elevate dopamine levels in PD-induced models.

Conclusion:

The results of this study revealed the beneficial effects of sesamin in the prevention and
management of NDs, including AD and PD; however, no clinical data supporting these effects in humans
is available, which highlights the need for designing clinical trials to evaluate the efficacy, proper
dosage, pharmacokinetics aspects, and possible side effects of sesamin in humans.
The Reactions of p-Tosylmethyl Isocyanide with Aldehydes in the Synthesis
of Heterocyclic Compounds: A Review
Authors: Vchislo Nadezhda V. , Fedoseeva Victoria G. , Verochkina Ekaterina A.
Published: May 2022

p-Tosylmethyl isocyanide (TosMIC) and its derivatives represent an important class of polyfunctional reagents, which makes them privileged “building blocks” in the targeted organic synthesis to design a plethora of heterocycles as well as natural products. This review summarizes and highlights the synthetic potential of p-tosylmethyl isocyanide and its derivatives in the reaction with various aldehydes to afford valuable heterocycles. The catalytic and technological innovations discussed in the review reveal the ease of reaction that is displayed in mechanistic schemes.
Engineered BMSCs-Derived Exosomal miR-542-3p Promotes Cutaneous
Wound Healing
Authors: Li Xiao-Lin , Xiong Qing-Hua , Zhao Lei , Wan Guan-Qun , Hu Yun-Gang
Published: May 2022

Background:

The healing of cutaneous wounds requires better strategies, which remain
a challenge. Previous reports indicated that the therapeutic function of mesenchymal stem cells is
mediated by exosomes. This work demonstrated the regenerative effects of engineered BMSCsderived
Exosomal miR-542-3p in skin wound mouse models.

Methods:

Bone marrow mesenchymal stem cells (BMSCs) -derived exosomes (BMSCs-Exos) were
isolated by ultracentrifugation and identified by Transmission Electron Microscope (TEM) and
Nanoparticle Tracking Analysis (NTA). BMSCs-Exo was loaded with miRNA-542-3p by
electroporation. We explored the effects of miRNA-542-3p-Exo on the proliferation and migration
of Human Skin Fibroblasts (HSFs)/Human dermal microvascular endothelial cells (HMECs). In
addition, The angiogenesis of HMECs was detected by Tube formation assay in vitro. The effects
of miRNA-542-3p-Exo in the skin wound mouse model were detected by H&E staining, Masson
staining, and immunofluorescence analysis. We assessed the effect of miRNA-542-3p-Exo on
collagen deposition, new blood vessel formation, and wound remodeling in a skin wound mouse
model.

Results:

MiRNA-542-3p-Exos could be internalized by HSFs/HMECs and enhance the
proliferation, migration, and angiogenesis of HSFs/HMECs in vitro and in vivo. The protein
expression of collagen1/3 was significantly increased after miRNA-542-3p-Exo treatment in HSFs.
In addition, the local injection of miRNA-542-3p-Exo promoted cellular proliferation, collagen
deposition, neovascularization, and accelerated wound closure.

Conclusion:

This study suggested that miRNA-542-3p-Exo can stimulate HSFs/HMECs function.
The treatment of miRNA-542-3p-Exo in the skin wound mouse model significantly promotes
wound repair. The therapeutic potential of miRNA-542-3p-Exo may be a future therapeutic strategy
for cutaneous wound healing.
Computational Studies and Biological Evaluation on Synthesized Lead 1,3-
diphenyl-4,5-dihydro-1H-pyrazole Moiety as Anti-Infective Agents
Authors: Manickavalli Elangovan , Kiruthiga Natarajan , Vivekanandan Lalitha , Roy Anitha , Sivakumar Thangavel
Published: May 2022

Background:

Chronic non communicable diseases were interlinked with inflammation and infections should response to starting core of major diseases in both acute and chronic conditions. In drug discovery, development of a drug which acts as anti-infective agents (anti-microbial and anti-inflammatory) must be ideal and challenging for management of many chronic diseases.

Objective:

In this study, six lead pyrazoline hybrids were synthesized by cyclization of chalcones and characterized by various spectroscopic and elemental analysis. All synthesized compounds were screened for anti-inflammatory and anti-microbial activity by computational tools and biological evaluation.

Methods:

Synthesized pyrazoline analogues were characterized by various spectroscopic techniques and evaluated for prediction of pharmacokinetics, physicochemical properties and Molecular docking studies of various targeted enzymes on microbial and inflammatory mediators. Those compounds were screened by anti-microbial and anti-inflammatory activities by several in-vitro and in-vivo methods.

Results:

The synthesized compounds (A1-A6) were screened for anti-inflammatory activity in which compound A2 produced effective percentage inhibition (45.8 %) potent activity compared with that of standard indomethacin (49.7 %) in carrageenan paw edema method were observed. The anti-microbial activity was screened on synthesized compounds, among which A3 [2-(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl) phenol, A2 [5-(4-chlorophenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole] produced potential percentage zone of inhibition between 80 - 70 % for bacterial strains and 94 - 89 % for fungal strains were observed. The minimum inhibitory concentration values of those compounds were 1.56 to 6.25 µg/ml for bacterial strains and 1.56 to 12.5 µg/ml for fungal strains were noted compared with the standard gatifloxacin and clotrimazole, respectively. The molecular docking, pharmacokinetics and toxicity predictions on those compounds were supported further for the development of potent anti-infective agents.

Conclusion:

The hypothesis of this research was correlated with the results of anti-inflammatory and anti-microbial activity. The binding interactions of respective enzymes were coincided with reduction of paw edema in anti-inflammatory model and zone of inhibition in anti-microbial activity were observed.
WITHDRAWN: In silico and Experimental Analysis of miR-125b-5 and
miR-485-5p Expression in Serum of Patients with Breast Cancer
Authors: Derakhshan Sima Mansoori , Bahmanpour Zahra , Sheervalilou Roghayeh , Khaniani Mahmoud Shekari , Poursheikhani Arash , Montazeri Vahid , Tahmasebivand Mahsa
Published: May 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has
been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

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must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Nephroprotective Effect of Methanolic Extract of Solanum nigrum (Mako) and its Fractions on Cisplatin-induced Nephrotoxicity in Albino Rats
Authors: Aslam Mohammad , Shiffa Mohamed , Javed Kalim , Rahman Shabana , Fahamiya Nazeem
Published: May 2022

Background:

Renal failure is an emerging problem worldwide and it is defined as the presence of renal parenchymal damage. Its manifestations are abnormal albumin excretion or decreased kidney function. Solanum nigrum L. (Mako), ‘Black Nightshade’, belongs to the family Solanaceae known in Unani medicine for its nephroprotective activity, especially in renal disease, as the berries are used to treat many renal ailments including renal failure.

Aim:

The aim of this study was to evaluate the nephroprotective activity of the berries of Mako on cisplatin-induced nephrotoxicity in rats.

Methods:

Wistar rats were divided into 7 groups of six animals in each. Group I served as the control, group II the toxicant group (cisplatin only), group III included the methanolic extract of Mako, group IV petrol soluble fraction of ME, group V chloroform soluble fraction of ME, group VI water soluble fraction of ME, and group VII the water soluble fraction of ME. All groups except for control group received a single dose of cisplatin 7 mg/kg injection on the 4th day, and test drugs were co-administered from day 1 to day 7. On the 8th day, samples were collected for the analysis of blood urea nitrogen (BUN), serum creatinine and for histopathological examination of renal tissues.

Results:

Results were analyzed using the one-way analysis of variance followed by Dunnett’s post hoc test. It was revealed that the ME of Mako and its fractions significantly reduced the rise in BUN and serum creatinine levels caused by cisplatin. The histopathological analysis also showed the protective nature of Mako in the nephrotoxic modules.

Conclusion:

Hence, the biochemical parameters and histopathological results affirmed the nephroprotective effect of the berries of the Mako against cisplatin-induced renal damage.
Kaolinite-Chitosan based Nano-Composites and Applications
Authors: Narayana Saibaba K.V.
Published: May 2022

Chitosan is a naturally available biopolymer, having numerous applications due to its unique physico-chemical properties. Kaolinite is one of the abundantly available clay, combining these two materials imparts excellent properties suitable for various applications. Although various chitosan-based composites are developed greater attention is focused on kaolinite- chitosan composites in recent years. This chapter discusses developments in various kaolinite- chitosan nanocomposites and their applications particularly in medical, pharmaceutical, wastewater treatment and food and packaging industries. First, discussion on chitosan and kaolinite is given, then kaolinite- chitosan nanocomposite fabrication, advances, development and followed by various applications of chitosan-kaolinite nanocomposites. Finally concluding remarks are presented to summarize latest developments in this area. Challenges and future perspectives are also given in conclusions to guide the research directions.
Vermiculite Starch-based Nanocomposites and Applications
Authors: Akram N.
Published: May 2022

Nowadays, the demand of biodegradable as well as biocompatible nanocomposites-based products is growing all over the world. In this perspective, a little effort is done in terms of exploring the effectiveness of environment friendly vermiculite starch-based nanocomposites. Both the constituents are naturally occurring so they are considered as low-cost materials. Different methods such as solution casting, melt solution blending as well as in-situ polymerization approaches are used for the fabrication of vermiculite starch-based nanocomposites. Functional characterization of nanocomposites can be investigated in terms of XRD, SEM, FTIR, TGA, DSC as well as by some mechanical testing methods. The resultant nanocomposites give attractive solutions in the subject of wastewater treatment and food packaging additionally may also exhibits improved fire properties that are resistive.
Nanomaterial-Supported Enzymes
Authors: Inamuddin
Published: May 2022

The book presents recent advances in the field of nanoenzymes and the immobilization of enzymes in nanomaterials. Applications include disease diagnosis, environmental clean-up, biosensor manufacturing, drug delivery and vaccine production.
Use of Nanomaterials-Based Enzymes in the Food Industry
Authors: Hussain I.
Published: May 2022

Natural enzymes perform pivotal role in all biological reactions in living things. But their practical operations are restricted due to difficulty in synthesis, reprocessing, cost, and easy denaturation. To combat these hurdles, blistering exertion is dedicated for improving these enzymes to other enzymes known “artificial enzymes.” The man-made enzymes, which possess enzyme mimicking properties, have fascinated researchers’ attentions. From last decade, nanozymes have attained tremendous progression. Nanomaterials-based enzyme elucidates expressive features like distinct preparative protocols, low cost, long duration for storage, and high stability towards environment than natural enzymes. This draft carries survey on 1) nanozymes literature, which is considerably explored by a diverse class of nanocomposites such as composites of halogens, carbon-based nanostructured materials etc.; 2) the recent progresses made in the fabrication of nanozymes for enzyme mimicking activity; 3) the mechanism of action, schemes to increase enzymatic activities, catalytic property and recent trends of using nanomaterials-based enzymes in the food industries.
Use of Nanomaterials-based Enzymes in Vaccine Production and Immunization
Authors: Singh M.
Published: May 2022

The production of standard vaccines is increasing rapidly. The improvement is needed due to соnсerns of low immunogenicity, instability, and the need for more vассines. To оverсоme these concerns, development of vассines has been integrated with and facilitated by nanotechnology. Nanotechnology is increasingly рlаying а key role in vaccination by the development of NP-based delivery systems which have aided in increasing cellular and humoral immune responses. The nano carrier-based system facilitates the delivery of vaccine antigens to target cells and increases antigen resistance and immunogenicity. Many nano-sized particles have been studied and are being used as adjuvants and vehicles to deliver vaccine antigens. The efficiency of NPs as nanocarriers is due to their size and рrоmоting specialized and selective immune responses. This сhарter will focus on nanonzyme аnd their use in vассine prоduсtiоn аnd immunizаtiоn.
Description of second and third instar larvae of Cuterebra histrio Coquillett, 1902 and first report of Metacuterebra apicalis (Guérin-Ménéville, 1835) (Diptera: Oestridae) in Veracruz, Mexico
Authors: Lara-Lagunes Nora , Jaume-Schinkel Santiago , Ibáñez-Bernal Sergio
Published: May 2022

En este trabajo se describen e ilustran por primera vez el segundo y tercer estadio larvario del tórsalo de roedor de la especie Cuterebra histrio Coquillett, 1902, además, se discuten caracteres morfológicos que pueden ser de utilidad taxonómica para la identificación de las larvas de distintas especies. Sumado a esto, se reporta por primera vez la presencia de la especie Metacuterebra apicalis (Guérin-Ménéville, 1835) en el estado de Veracruz, México.
Features of Production Management in the Telecommunications Sector
Authors:   Southwest State University, Kashirtseva Anna Yu.
Published: May 2022

Relevance. Management processes at any level tend to constantly become more complicated and to increase their effectiveness, it is necessary to review and improve its individual aspects. This is why the importance of production management as a specific type of activity for managing the main business processes of an organization is now especially great. The modern economic reality creates conditions under which it is necessary to constantly improve management practices to increase the competitiveness of the product produced by the organization. All this is typical for such rapidly developing industries as telecommunications. The purpose of the research presented in the article is to identify the features of production (operational) management in the telecommunications sector in order to find optimal ways to improve it. The objectives of the research are to identify the universal principles of modern production management; to identify the features of the main business processes of companies in the telecommunications industry; to formulate the features of production management in the telecommunications sector; development of the main directions for improving the production management of the telecommunications sector. The research methodology includes general scientific methods such as comparative analysis of sources, system analysis and synthesis of facts, induction and analysis. The result of the study is a list of features of production management in the telecommunications sector and current ways to improve it. The author draws conclusions that production (operational) management is a specific type of management activity that allows you to manage the main business processes of organizations and increase the competitiveness of the organization's product, while having its own main characteristics, features and development paths. In addition, there are certain features of production (operational) management in the tele-communication sphere, the identification of which allows us to identify ways to improve it.
Concept, Classification and Methodology for Measuring Socio-Economic Inequality: Problems and Solutions
Authors:   Financial University under the Government of the Russian Federation, Dorofeev Mikhail L.
Published: May 2022

Relevance. The challenges standing against the world economy because of the COVID-19 pandemic have required regulators to use unconventional financial policies to stimulate economic growth. This has had a certain impact on the dynamics of poverty and economic inequality. From this perspective, the topic is particularly relevant today and requires a large number of new questions to be answered. Research on socio-economic inequality involves many different terms and indicators, which are sometimes used incorrectly, creating some terminological and methodological confusion in the scientific discussion. In this regard, it is important to study all these theoretical problems and clarify the concept, classification of socio-economic inequalities, as well as issues related to the quality of data and its methods of assessment. The purpose of the work is to solve a number of theoretical and methodological problems related to the essence, classification and methodology of assessing the socio-economic inequality of households. Objectives: define the socio-economic inequality of households; propose a classification of types of socio-economic household inequality; justify the problem of completeness, quality and comparability of data in analysis and international comparisons of the level and dynamics of socio-economic inequality of households and suggest ways to solve it. Methodology. The study used methods of analysis, and synthesis of scientific papers and graphical analysis of statistical data. Results. the definition and classification of types of socio-economic inequality have been clarified; the problem of data quality, which makes it difficult to form an objective assessment of socio-economic inequality was justified: the problem of the complexity of international comparisons, going from the usage of different methodologies for assessing the subject of the study in different countries, is also justified. Conclusions. It is proposed to continue developing and enhancing the system of statistics and analysis of socio-economic inequality of households on the base of international standards and in closer international cooperation between countries, as this will allow to get a deeper understanding of economic inequality problem and the wok out adequate policies of state financial regulation.
The Concept of Education 4.0 and Contemporary Challenges to the System of Professional Training for the Digital Economy
Authors:   MIREA - Russian Technological University, Shatskaya Irina V.
Published: May 2022

The relevance of the scientific research of the concept of education 4.0, as well as the trends accompanying the process of digital transformation of education, is due to the following reasons: the need to change the structure of education management in the process of digital economic development; search for optimal methods to solve the problem of matching the content of education with the priorities and goals of the national economy. The purpose of the study is to study the concept of education 4.0 in the context of its impact on the training of personnel for the digital economy, as well as to consider the opportunities and challenges of digital transformation of education. Objectives. In accordance with the goal, the following tasks were set and solved: to study the content of the stages of development of the education system within the framework of the technological changes observed in the economy; identify trends in the digital transformation of education; to formulate the opportunities and challenges of digital transformation that determine the priorities of the future development of the professional training system for the digital economy. Methodology. The theoretical and methodological basis of the research is the scientific achievements of domestic and foreign scientists on the digital transformation of the education system. To substantiate the achieved results, a set of scientific methods and approaches was used: analysis and synthesis, comparison, generalization, scientific abstraction. The paper uses a retrospective approach to the category "education 4.0". The research is based on the publications of foreign and domestic authors on the studied issues and problems. Results. As a result of the research, the content of the concept of education 4.0 is revealed, global trends in education are formulated, the characteristics of digital technologies used in the educational process are given, opportunities and challenges that determine the future of education are formulated. Conclusions. It is proved that even now educational organizations should pay attention to the structural changes that digitalization entails, and use the material in the educational content that forms the knowledge and skills necessary for students to adapt to it.
The COVID-19 Pandemic and Its Impact on Public Health Production
Authors: Shugaeva Olga V.
Published: May 2022

Relevance. The economic downturn during the introduction of restrictive measures in connection with the COVID-19 pandemic determines the urgency of developing measures and proposals to ensure the sustainable development of various spheres of social production. The purpose of the study is to develop proposals to support and ensure the development of tangible and intangible production in the Russian Federation during the COVID-19 pandemic. Objectives: analysis of the impact of the COVID-19 pandemic on the global economy as a whole and the Russian Federation, in particular; identification of the most affected, not affected and had a positive growth in the spheres of social production, development of the main directions of their further development. Methodology. The methodological base of the study is based on a systematic analysis of data obtained from available sources, observations and personal experience of the author, as well as the use of economic and mathematical methods and expert opinion of specialists from specialized industries. Results. As a result of the analysis, the industries most affected by the introduction of restrictive measures in connection with the COVID-19 pandemic were identified. The most affected areas of activity have been identified, and possible consequences of others that may manifest themselves in the short term. Proposals have been developed for the stabilization and development of various spheres of material and non-material production. Conclusions. The COVID-19 pandemic had a twofold impact on social production: on the one hand, certain industries declined, and on the other hand, it created prerequisites for the development of other spheres of social production. At the same time, the introduction of digital technologies and the development of information and communication systems became particularly relevant, which led to the economic transformation of production.
The Impact of Telemedicine on Physicians’ After-hours Electronic Health Record “Work Outside Work” During the COVID-19 Pandemic: Retrospective Cohort Study
Authors: Lawrence Katharine , Nov Oded , Mann Devin , Mandal Soumik , Iturrate Eduardo , Wiesenfeld Batia
Published: May 2022

Background

Telemedicine as a mode of health care work has grown dramatically during the COVID-19 pandemic; the impact of this transition on clinicians’ after-hours electronic health record (EHR)–based clinical and administrative work is unclear.

Objective

This study assesses the impact of the transition to telemedicine during the COVID-19 pandemic on physicians’ EHR-based after-hours workload (ie, “work outside work”) at a large academic medical center in New York City.

Methods

We conducted an EHR-based retrospective cohort study of ambulatory care physicians providing telemedicine services before the pandemic, during the acute pandemic, and after the acute pandemic, relating EHR-based after-hours work to telemedicine intensity (ie, percentage of care provided via telemedicine) and clinical load (ie, patient load per provider).

Results

A total of 2129 physicians were included in this study. During the acute pandemic, the volume of care provided via telemedicine significantly increased for all physicians, whereas patient volume decreased. When normalized by clinical load (ie, average appointments per day by average clinical days per week), telemedicine intensity was positively associated with work outside work across time periods. This association was strongest after the acute pandemic.

Conclusions

Taking physicians’ clinical load into account, physicians who devoted a higher proportion of their clinical time to telemedicine throughout various stages of the pandemic engaged in higher levels of EHR-based after-hours work compared to those who used telemedicine less intensively. This suggests that telemedicine, as currently delivered, may be less efficient than in-person–based care and may increase the after-hours work burden of physicians.
Slurs in Identity Politics
Authors: Conduit Ed
Published: May 2022

Slurs are words that diminish the worth of members of our groups. The UK broadcast regulator Ofcom has a list of highly offensive terms that it recommends broadcasters not to use. Bangladeshis, Poles, Greeks and lower-class white males remain of low visibility to Ofcom. Four identities that have high visibility in broadcast television were found to show low levels of slurs and Israeli to have a moderate level. British Asian Muslim identity has many pejorative terms, though most are Arabic and not well-known in English. The terms “gonimoter maal” and “gawur” could be considered severe slurs as they have resulted in rape or murder. “Misogyny” is currently used freely by broadcasters. Thorough lexicology here failed to find a credible psychology for “hatred of women” or a credible set of actions. Presumed actions were found to be mass nouns combining threat, non-sentience, pathology, doctrine, quirk, sometimes crime, and sometimes a comparison with harmful chemicals. They remove sentience from the adversary and preclude empathy and dialogue. Ofcom might ask respondents if they consider “misogynist” a slur.
Characteristics and trends of scientific-technical publications on plantations and agroforestry systems
Authors: Flores Andrés , Correa-Díaz Arian , Moctezuma-López Georgel , Pérez-Miranda Ramiro
Published: May 2022

Forest plantations management demands generating knowledge and developing innovative technologies that make their production process more efficient. The objective of this research was to analyze the characteristics and trends of scientific publications from the Centro Nacional de Investigación Disciplinaria en Conservación y Mejoramiento de Ecosistemas Forestales (National Center for Disciplinary Research in Conservation and Improvement of Forest Ecosystems) from Mexico produced from 1994 to 2021, by the Plantations and Agroforestry Systems research program. A documentary review was performed in scientific journals and documents with an editorial committee; the compiled information was systematized and analyzed through graphs prepared in Microsoft Excel®. A total of 36 documents were found for three periods: 18 documents from 2019-2021 (52.78%), 14 documents from 2008-2018 (38.89%), and three (8.33%) from 1994-2007. Specifically, 30 scientific articles, five technical guidelines, and one book chapter were published from 1994 to 2021. The main research topic from 1994 to date was conservation. Their keywords analysis indicates that the main study subject was the Pinus genus. Regarding their geographical scope, 40 works were carried out at five levels: one international, twelve national, seven regional, fourteen states level, five municipal, and one local. Most of the studies (77.78%) were published in Mexican journals and publishers. The number of reported species in these documents amounted to 90. To increase its impact in the coming years, it is advisable to strengthen the research carried out with other institutions and researchers.
Adaptation to raw materials intra-variability: Examples from three Middle Palaeolithic surface stations of the Hérault Valley, France (Les Geissières, Saint-Saturnin and Camillo)
Authors: Mathias Cyrielle , Bourguignon Laurence , Ivorra Jérôme , Barsky Déborah , Grégoire Sophie , Viallet Cyril
Published: May 2022

Up to now, little was known about the Middle Palaeolithic from the Hérault Valley (France). Recently, systematic surveys have led to the discovery of several surface stations on river terraces. Some of these have yielded stone tools made from unusual raw materials, such as, brecciated quartzites and jasper-like rocks, as well as quartz and rare flints. These rocks are found in primary position in the Montagne Noire area, and are also available in the alluvial deposits of the Hérault and its tributaries in the form of more or less rounded cobbles. These raw materials are very heterogeneous even within a single cobble. Their inter and intra-variability has been found to have induced specific knapping strategies as hominins adapted to - or took full advantage of - their special petrographic characteristics.

Here we present data from three Middle Palaeolithic open-air stations (Les Geissières, Saint-Saturnin and Camillo) to illustrate adaptive knapping strategies performed by Neanderthals. In addition to the technological analysis, experiments were also conducted to test some of the identified methods, such as bipolar-on-anvil, with the aims of: 1) evaluating flake production efficiency and 2) recognizing specific traces left on the products by this method. This enabled us to better identify archaeological artefacts in this particular alluvial context.

The study shows the use of stone reduction methods that allowed the knappers to adapt to the constraints posed by the raw materials: Discoid sensu lato (bifacial, unifacial, partial), Clactonian and bipolar-on-anvil. Methods more diagnostic of the Middle Palaeolithic, such as the Levallois and typo-Levallois or various Kombewa methods were used on finer grained raw materials. There are a few retouched flake tools and some pebble tools (mainly choppers). These assemblages show us that, despite the influence of the raw materials (which is more of a constraint than a limit), Neanderthals achieved their goals through a variety of methods.

These surface stations make it possible to better perceive adaptive strategies in the Middle Palaeolithic in Languedoc-Roussillon, in a context where the Levallois techno-complexes prevail.
Manufacturing technology of stone miniature columns from the Bronze Age site Gonur Depe (southern Turkmenistan)
Authors: Skakun Natalia Nikolaevna , Terekhina Vera Vladimirovna
Published: May 2022

Archaeological cultures of the Bronze Age, despite the widespread use of metal, also used stone raw materials for the manufacture of tools, household, and sacred items. A lot of stone products had a complicated shape and meticulous finishing, but the technology of their manufacture is still not always clear. This fully applies to the materials of the Bronze Age of southern Turkmenistan where long-term settlements of the proto-urban type are being studied. These include Gonur Depe (2500-1500 BCE) - the administrative and religious centre of ancient Margiana (Sarianidi 2005). Among its materials are stone miniature columns of “unknown” purpose in the shape of a chess rook, which are usually found in sacral complexes. This paper deals with the technology of producing these objects (half of the collection of intact items was investigated) and is part of a collective work on a comprehensive study of large stone cult objects from Gonur Depe. The raw materials for studied miniature columns were gypsum, limestone, marbled limestone, marbled onyx, onyx, talcochlorite, and polymictic breccia. For the first time the authors made an attempt to consider the issues of miniature columns manufacturing technology. Thanks to the use-wear study of their surfaces, it became possible to reveal numerous technological traces invisible to the naked eye. The data obtained made it possible to characterize all stages of the miniature columns manufacturing technology, which indicates a high level of development of the stone-processing industry in the settlements of the Bronze Age of Turkmenistan.
Functional use of large stone tool from the Upper Paleolithic site of Kamennaya Balka II (the Northern Azov Sea region, Russia)
Authors: Skakun Natalia Nikolaevna , Longo Laura , Terekhina Vera , Pantyukhina Irina , Vinogradova Ekaterina , Shulga Dmitrii
Published: May 2022

The assemblages of many Paleolithic sites on the Russian Plain contain large pebbles of various types of stone, which, due to the natural and unmodified forms, rarely become objects of special study. Some of them retain their natural shape, others are slightly artificially modified. In the course of our research, artifacts from several Paleolithic sites in Russia and the Republic of Moldova were subjected to a comprehensive study. Technical-morphological and experimental-traceological studies made it possible to characterize the methods of their manufacture and use. Among the items studied, there is a trapezoidal slab retrieved in the lower layer of the Late Paleolithic stratified site Kamennaya Balka II (the Northern Azov Sea region, Russia). On its surface, use-wear traces were found, which are characteristic of wear traces on tools used to grind plant materials. To verify the results of the traceological analysis, a series of experiments was performed. The wear traces on the working part of the experimental tool turned out to be similar to those found on the original one. The functional identification of the slab from Kamennaya Balka II as a tool for processing plants was also confirmed by the discovery on the working surface of mineralized starch grains.

This comprehensive study of an unmodified stone artifact from the Kamennaya Balka II site and its identification as the lower grinding stone indicates the presence of complex foraging strategies among the economic activities of the inhabitants of the site and their successful adaptation to the natural environment in this region.
Rock Mortars of Sar Pol-e Zahab in their Archaeological Contexts: Evidence of third and second Millennium BCE Nomads Camp Sites in Western Foothills of Zagros Mountain, Iran
Authors: Alibaigi Sajjad , MacGinnis John
Published: May 2022

During the 2016 archaeological survey in the Sar Pol-e Zahab region, in the border zone between Mesopotamia lowland and Iranian highland, a number of rock mortars were discovered on the edges of seven ancient sites. Owing to its climate and topography and its winter pastures, this region has long been favoured by nomads, and numerous remains of nomadic activities survive. The sites in question are small settlements that have been attributed to nomadic occupation owing to their small area, thin occupational deposits and extremely limited finds. Most of these sites are located near water sources such as springs and rivers. Furthermore, the associated cultural materials are not of high quality. This is in stark contrast to the settlements of farmers and sedentary settlers in the central range and western foothills of the Zagros, the remains of which formed relatively large mounds with complex stratigraphy representing extended occupations accompanied by cultural materials showing a higher degree of workmanship and artistry. In many cases, these characteristics are enough to distinguish the settlements of sedentary farmers from those of herdsmen and nomads. It appears that the nomads of the region, particularly in the third-second millennium BCE and in the Parthian period, used these permanently located rock mortars to grind grains and cereals during their seasonal occupation of these sites. These mortars are not out of context, they are related to the ancient settlements on whose periphery they are found.
ОСОБЕННОСТИ ПРОЦЕССА ЖИДКОФАЗНОГО МАГНЕТРОННОГО РАСПЫЛЕНИЯ ДЛЯ РАЗЛИЧНЫХ МАТЕРИАЛОВ
Authors: Назаренко М. , Моисеев К. , Сигов А.
Published: May 2022

Рассмотрены особенности процесса жидкофазного магнетронного распыления (ЖФМР) для различных материалов. Отмечено, что метод ЖФМР благодаря своей универсальности и экологичности обладает большим потенциалом к замещению существующих производственных методов, предназначенных для формирования толстых слоев металлизации различного назначения.
ЦИФРОВЫЕ ИС: ПЕРСПЕКТИВЫ РАЗВИТИЯ СХЕМ ПАМЯТИ И ИХ ПРИМЕНЕНИЕ В СИСТЕМАХ ИИ
Authors: Черепанов И. , Макушин М.
Published: May 2022

Анализируются тенденции развития сектора схем памяти. Большое внимание уделено освоению подходов 3D-интеграции, в том числе созданию приборов, сочетающих этажерки памяти и слои логических приборов, процессорных ядер и т. п.
Linear and nonlinear shelf space allocation problemswith vertical and horizontal bands
Authors:   Department of Process Management, Czerniachowska Kateryna ,   Faculty of Management,   Wroclaw University of Economics and Business, Poland, Lutosławski Krzysztof ,   Department of Process Management; Faculty of Management; Wroclaw University of Economics and Business, Poland, Hernes Marcin ,   Department of Process Management; Faculty of Management; Wroclaw University of Economics and Business, Poland
Published: May 2022

Aim/purpose – Shelf space is one of the most important tools for attracting customers’ attention in a retail store. This paper aims to develop a practical shelf space allocation model with visible vertical and horizontal categories. and formulate it in linear and non- -linear forms. Design/methodology/approach – The research is mainly based on operational research. Simulation, mathematical optimization, and linear and nonlinear programming methods are mainly used. Special attention is given to the decision variables and constraints. Changing the dimensioning of the decision variables results in an improvement in the formulation of the problem, which in turn allows for obtaining an optimal solution. Findings – A comparison of the developed shelf space allocation models with visible vertical and horizontal categories in linear and nonlinear forms is presented. The compu- tational experiments were performed with the help of CPLEX solver, which shows that the optimal solution of the linear problem formulation was obtained within a couple of seconds. However, a nonlinear form of this problem found the optimal solution only in 19 out of 45 instances. An increase in the time limits slightly improves the performance of the solutions of the nonlinear form. Research implications/limitations – The main implication of research results for sci- ence is related to the possibility of determining an optimal solution to the initially formu- lated nonlinear shelf space allocation problem. The main implication for practice is to take into consideration the practical constraints based on customers’ requirements. The main limitations are the lack of storage conditions and holding time constraints. Originality/value/contribution – The main contribution is related to developing math- ematical models that consider simultaneous categorization of products vertically, based on one characteristic, and horizontally, based on another characteristic. Contribution is also related to extending the shelf space allocation theory with the shelf space allocation problem model in relation to four sets of constraints: shelf constraints, product con- straints, orientation constraints, and band constraints. Keywords: Retailing, decision making/process, merchandising, shelf space allocation, planogram. JEL Classification: C61, L81.
Cross-sectional Analyses of Self-employed & Directly Employed Workers’ Job-specific Well-being In Creative and Corporate Workplaces
Authors: Maguire Larry Gerard , Hyland John
Published: May 2022

The current mixed-methods study explored differences in Job Specific Well-being (JSWB) amongst self-employed  and directly-employed workers in creative and corporate workplaces. A descriptive, cross-sectional design with open ended questions, employing purposive sampling, was used. A self-report, mixed method, digital questionnaire was used for data collection and respondents (N=230) were sourced globally. Analyses showed a significant difference in JSWB for overall self-employed compared with overall directly-employed workers. An effect of supervisory responsibility on JSWB was observed among groups of directly-employed workers. For self-employed workers, no significant effect of supervisory responsibility was seen for levels of JSWB. Additionally for self-employed workers, no significant difference in JSWB was seen based on “necessity” or “opportunity” self-employment. Generally, findings showed that both self-employed and directly employed workers in the current sample were dissatisfied with daily work. Findings were mixed, and results prompt important considerations for existing research.
Cookies ‘n’ Consent: An empirical study on the factors influencing of website users’ attitude towards cookie consent in the EU.
Authors: Jayakumar Lakshmi Narayanan
Published: May 2022

Since GDPR came into enforcement in 2018, various firms have been found violating or circumventing the ePrivacy Directive known as the Cookie Law which lays out the cookie consent guidelines for websites. To improve the GDPR compliance rate, several conversations are going on between EU commission, Data protection agencies, business & websites owners and ad vendors regarding their cookie policy, obtaining user consent for data collection and its usage. One of the key stakeholders who are the website users, whose privacy is in question seems to be left out from the discussions. The study aimed to understand user perception towards website cookie banners, which are mandatory under GDPR, and the influence of factors like awareness of cookies, user experience, consent banner design, privacy risk, brand trust on user’s willingness for accepting all cookies, to develop recommendations to improve customer’s motivations to give consent. Using a quantitative approach, the primary data was collected from 132 internet users residing in the EU region through an online survey questionnaire shared in social media networks. The results showed that the (i) majority of respondents had more than moderate level of awareness about cookies (ii) they are more likely to accept cookies for quick access or task completion, (iii) acceptance of cookies was varied across different categories of online activity and (iv) given a choice they are more likely to opt-out of 3rd party cookies which are widely used for targeted advertising. Since 3rd party cookies will be phased out in the near future and are likely to be replaced with more advanced customer tracking technologies which are harder to opt-out of, this study proposes a framework for Consent for Advertising Directive (CAD) to go beyond the existing Cookie Law, which will improve user data protection regardless of the tracking technology used, and help brands to improve transparency about their data collection and avoid GDPR violations.
An examination of social media use and the FA Women’s Super League: The challenges of going professional
Authors: Carragher Ann Marie , Lolich Luciana
Published: May 2022

This paper explores the use of social media, specifically Twitter, in two English football clubs during their first season under the professional structure of the WSL. The study uses data from the clubs’ Twitter accounts and interviews with key employees. A total of 1088 tweets were analysed. Four themes emerged: player availability; status; cooperation and social media strategy. The findings showed that while women’s football has made great strides, the increase use of social media by players has been not supported by proper media training. Furthermore, the increase in status has not been matched by better funding. It is important than the increase awareness surrounding women’s football is matched by an increase in player well-being as this will impact the standing of women’s football.
Confederación Perú-Boliviana
Authors: Gonzales Jauregui Yobani
Published: May 2022

La confederación Perú-Boliviana fue un proyecto político que buscó la unificación de Perú y Bolivia en un solo estado y con una clara política librecambista, que en su aplicación lo- gró mejorar significativamente las arcas del estado peruano. Sin embargo, el florecimiento comercial y la aparente estabilidad política generaron reacciones adversar en los países vecinos como Chile y Argentina, quienes declararon la guerra, no solamente bélica, sino librada igualmente en los periódicos de la época.
Peronismo y la Iglesia Católica (1946-1955)
Authors: Vera Mendoza Gabriel
Published: May 2022

Durante las décadas de 1940 y 1950 en Argentina se desarrolla un peculiar movimien- to en torno a la figura de Juan Domingo Perón; movimiento que entablaría fuertes relaciones con la Iglesia católica para fortalecer su influencia hacia la población, especialmente entre las clases populares. Esta relación se desarrolla entre la sumisión y la desobediencia, aspecto este último que agrupa las diferentes resistencias y desencantos hacia el peronismo como catalizador de la movilización para la desestabilización del gobierno de Perón en 1955.
Historiografía sobre la Guerra de los Mil días: un balance
Authors: Monterroza Morelo Julio
Published: May 2022

La Guerra de los Mil Días fue la última de las guerras civiles del siglo XX en Colombia, y como tal ha convocado varios textos de mayor o menor importancia. Con la profesionalización de la historia en Colombia, desde los historiadores se asumió la tarea de acercarse a dicho fenómeno con espíritu científico: las versiones sobre la guerra fueron sometidas a control empírico, y dieron lugar a unas nuevas versiones y unos nuevos debates.