bluuebunny/crossref_metadata_2025 huggingface dataset:
A gamificação como apoio no ensino de metodologia científica: Um relato de experiência e lições aprendidas no domínio de ciências agrárias
Authors: Mercês Freitas Danilo , Toda Armando
Published: January 2023

A gamificação tem atraído atenção de educadores nos últimos anos, devido aos benefícios relacionados à motivação e engajamento, que podem impactar no desempenho dos alunos. No entanto, para que esses efeitos sejam alcançados, é necessário um bom planejamento, baseado em evidências empíricas, sobre o design da gamificação. Com base no exposto, este estudo visa demonstrar o relato de experiência da aplicação da gamificação, num contexto de sala de aula, para apoiar o ensino de metodologia científica. Para este estudo, foram selecionadas uma turma de três cursos distintos (N = 150 alunos), nas quais foram aplicadas estratégias gamificadas. Os resultados foram analisados de um ponto de vista qualitativo e demonstraram que os alunos se interessam mais em uma aula gamificada, no entanto o trabalho individualizado tornou a aplicação da gamificação impráticável pelo professor, necessitando um novo planejamento em tempo real.
Um Web App com elementos de u-learning e gamificação voltado ao contexto da pedagogia da alternância
Authors: Souza Oliveira Fábio Cristiano , Ribeiro Freitas Helder , Cavalcanti Ramos Jorge Luis , Rodrigues Diniz Márcio
Published: January 2023

A U-learning emerge como um novo paradigma educacional que possibilita aprendizagem contínua, contextualizada e colaborativa, destacadamente, em espaços urbanos. Por outro lado, a educação do campo tem ficado a margem desses avanços, sendo necessário uma reflexão sobre a importância de se buscar desenvolver alternativas para diminuir essa lacuna existente. Este trabalho tem o objetivo de apresentar um sistema desenvolvido com elementos da aprendizagem significativa ubíqua e gamificação voltado para cursos de agroecologia, que adotam a pedagogia da alternância como método educativo muito presente em iniciativas da educação do campo. Para guiar os procedimentos realizados, foi empregada a Design Science Research Methodology. Como resultado, obteve-se um artefato de software com potencial de contribuir com a formação dos aprendizes de maneira colaborativa e contextualizada.
Literature review on technologies and games that motivated people to practice physical activity during the pandemic
Authors: Sendacz Nayara , Isotani Seiji , Araujo Lima Danielli
Published: January 2023

With the pandemic arrival, changes in people’s lives have become increasingly frequent, also affecting the education and physical health sector. As a consequence, many schools, gyms and clubs ended up closing. However, so that the activities did not stop, there was a need to adapt to technology, involving digital classes, physical activities with the use of applications and data analysis using data science. For this article, a systematic review was carried out, with the objective of evaluating the motivation to practice physical activities during the pandemic (2020 - 2021). We found (226) articles, selected (49) articles and extracted (16). The results, for the most part, were positive for the use of technologies in the practice of physical activities. Thus, the research carried out here reinforces the importance for more research in the area of physical education, health and well-being of people, mainly due to the decrease in this practice due to Covid-19.
Fuzzy Matrix Theory and Infertility Management – Measures Follicle Fertilization Possibility
Authors: V. Raich Vivek , Gangele Sharad , Verma Nutan
Published: January 2023

In this paper, we are exploring fuzzy logic in medical diagnosis of infertility where our aim is to predict the possibility of total fertility using fuzzy matrix theory by measuring the follicle fertilization possibility based on follicle size. Also developed a computer program to calculate fuzzy matrix based on MaxMin rule using JavaScript.
Weak Domination Alteration Sets in Fuzzy Graphs
Authors: Hussain R. Jahir , Banu S. Ameena
Published: January 2023

In general yf (G) can be made to increase or decrease by the removal of nodes from fuzzy graph G. In this paper the effect of the removal of a node of a fuzzy graph on weak fuzzy dominating set is studied. Further the stability of weak fuzzy domination number of fuzzy graph is investigated.
Computing Certain Degree Based Topological Indices and Coindices of E-graphs
Authors: G. Mirajkar Keerthi , Pooja B
Published: January 2023

In this paper, we obtain the explicit formulae for general sum-connectivity index, general product-connectivity index, general Zagreb index and coindices of G-networks, extended G-networks and -networks.
General Fifth M-Zagreb Indices and Fifth M-Zagreb Polynomials of PAMAM Dendrimers
Authors: V.R.Kulli
Published: January 2023

A molecular graph or a chemical graph is a simple graph related to the structure of a chemical compound. In this paper, we introduce the general fifth M-Zagreb indices and fifth M3-Zagreb index and their polynomials of a molecular graph. Also we compute the general fifth M-Zagreb indices and fifth M3-Zagreb index of PAMAM dendrimer graphs. Finally, we compute the fifth M3-Zagreb polynomial of PAMAM dendrimer graphs.
Type-2 Fuzzy Soft Sets on Fuzzy Decision Making Problems
Authors: V.Anusuya  , B.Nisha
Published: January 2023

Making decision is one of the most fundamental activities of human being. Decision making is a study of how decisions are actually made better. Applications of fuzzy sets within the field of decision making consisted of fuzzifications of the classical theories of decision making. Decisions are made under conditions of uncertainty is the prime domain for fuzzy decision making. In this paper, we have applied the notion of similarity measure and inclusion measure between Type-2 fuzzy soft sets to verify their relationships. This relation is used to obtain a solution of a decision making problem.
Fuzzy Valued Measure Based on Integral, Decomposition and Representation under Closed Intervals
Authors: D.Rajan  , A.Beulah
Published: January 2023

Fuzzy valued measure is a mapping which maps a σ- algebra to a set of fuzzy set with convex compact σ- level defined on banach space (β). In this paper, we investigate the notion of decomposition and representation of fuzzy valued measure (F.V.M) is given in the sequence of singular valued measure. Also we have been studied and develop the notion of integrals with the aid of F.V.M under closed intervals based on the proposed notions, we can prove relevant theorems.
A Fuzzy Inventory Model for Deteriorating Items with Linear Price Dependent Demand in a Supply Chain
Authors: Saha Sujata , Chakrabarti Tripti
Published: January 2023

In this paper we have developed a supply chain production inventory model for deteriorating items under fuzzy environment. Demand is taken as linear price dependent. In reality it is seen that we cannot define all parameters precisely due to imprecision or uncertainty in the environment. So we have defined the inventory parameters, such as set up cost, holding cost and deteriorating cost as triangular fuzzy numbers. The signed distance method and graded mean integration method have been used for defuzzification. To illustrate the proposed model a numerical example and sensitivity analysis with respect to different associated parameter has been presented.
Pareto Optimal Solutions of the Fuzzy Multi-Index, Bi-Criteria Fixed Charge Transportation Problem
Authors: Sing Sungeeta , Tuli Renu , Sarode Deepali
Published: January 2023

In this paper, a multi-index, bi-criteria, fixed charge transportation problem (MIBCFCTP) is considered in which the parameters of cost and duration are taken as trapezoidal fuzzy numbers. An algorithm incorporating an extended VAM and an extended MODI method is developed to find Pareto optimal solutions of the problem. The algorithm is illustrated with a numerical example and solutions obtained are compared with existing methods.
Some Notes on Pentagonal Fuzzy Numbers
Authors: J. Kamble Avinash
Published: January 2023

The aim of this paper is to discuss the basic concept pentagonal fuzzy number (PFN). Canonical pentagonal fuzzy numbers are discussed by means of internal arithmetic operations by using α -cut operations.
Level Separation on Intuitionistic Fuzzy T0 Spaces
Authors: Islam Md. Saiful , Hossain Md. Sahadat , Asaduzzaman Md.
Published: January 2023

The purpose of this paper is to introduce and study the intuitionistic fuzzy T0 spaces. We give eight new notions of intuitionistic fuzzy T0 spaces and investigate some relations among them. Also we investigate some relations between our notions and other given notions of intuitionistic fuzzy T0 spaces. Further, we study hereditary and productive property of such spaces. Moreover, under some conditions it is shown that image and preimage preserve intuitionistic fuzzy T0 spaces.
Common Fixed Point Theorems in Fuzzy Metric Spaces Using CLR Property
Authors: Singh Balbir , Kumar Pawan , Ansari Z.K.
Published: January 2023

In this paper, we prove some common fixed point theorems for weakly compatible mappings in Fuzzy metric space using the notion of CLR and JCLR property.
Intuitionistic Fuzzy Sets and its Applications in Medical Diagnosis
Authors: Samuel A.Edward , S.Rajakumar
Published: January 2023

In this paper, we propose a new approach for medical diagnosis with the symptoms of disease using intuitionistic fuzzy sets with extended modal operators for negation.
The Optimal Contract Complexity for Coordination Mechanisms of Supply Chain
Authors: Lei Yi-feng , Zhou Jun , Zhou Ting
Published: January 2023

This paper considers a supply chain system which consists of a supplier and a retailer. The purpose is to investigate the impact of contract complexity on supply chain coordination under complete information. The supplier drafts contracts, which include wholesale price contracts and simple quantity discount contracts. These contracts are of different complexity. The retailer chooses one of the supplier-designed contracts to optimize its profit. This study shows that a complex contract with an infinite number of price breaks can achieve the coordination of a general supply chain. It can also arbitrarily distribute supply chain profit under mild conditions. Theoretically, this is the optimal contract. However, it is difficult to implement in practice. Complex contracts with limited price breaks can improve the performance of the decentralized supply chain system compared to simple contracts (i.e. wholesale price contracts), but neither can coordinate the general supply chain. In addition, as the complexity of the contract increases, the performance of the decentralized supply chains continues to decline. This means that the increased in contract complexity does not necessarily increase the efficiency of supply chain contracts. Our study suggest that a three-price contract (all-unit quantity discount contract with two price breaks), although theoretically suboptimal, is sufficient for a general supply chain and should be preferred in practice.
Procedural Regulation of Information Content Review Rules of Network Platforms
Authors: Yuan Jun
Published: January 2023

Online platform information content review rules are the normative basis for platforms to regulate their internal activities and ensure the security of online information content. They are also an important object for platforms to perform their governance responsibilities under the co-governance order and should be reasonably established on the basis of complying with legal provisions. In order to exercise the private power of censorship of illegal information content, online platforms establish rules for censorship of information content based on legal authorization and their own influence, and the operation of this rule should conform to the standard of procedural justice. Specifically, the process of formulating the rules should be transparent while guaranteeing the user's right to participate, and the basic due procedures should be guaranteed in advance when making decisions based on the rules. At the same time, platforms should be required to establish a reasonable content review mechanism. The improvement of the relevant procedures of the information content review rules can enhance the credibility of the platform rules, thereby ensuring the platform autonomy and network governance environment.
Should the Decisions of the International Court of Justice and the Work of the International Law Commission be Recognized as Binding Sources of International Law?
Authors: Yinan Yu
Published: January 2023

This year marks the 76th anniversary of the first sitting of the International Court of Justice, and the article 38(1) of the Statute of the International Court of Justice is considered to be one of the most authoritative guides for ICJ when deciding international disputes. However, whether this provision is complete and covers all the sources of international law are of concern. Someone argues that decisions of the International Court of Justice, and the work of the International Law Commission, should be recognized as binding sources of international law as well. This essay is going to focus on the sources of international law listed in the article 38(1) of the Statute and other possible sources which are not included in this article. In addition, it will discuss the judicial decisions of the ICJ, the work of ILC, and the reasons for not adding them into the sources of international law.
Quadratically Optimal Bi-Matrix Games
Authors: Lahiri Somdeb
Published: January 2023

In this paper, we introduce the class of quadratically optimal (bi-matrix) games, which are bi-matrix games whose set of equilibrium points contain all pairs of probability vectors which maximize the expected pay-off of some pay-off matrix. We call the equilibrium points obtained in this way, quadratically optimal equilibrium points. We prove the existence of quadratically optimal equilibrium points of identical bi-matrix games, i.e. bi-matrix games for which the two pay-off matrices are equal, from which it easily follows that weakly potential bi-matrix games (a generalization of potential bimatrix games) are quadratically optimal. We also show that those weakly potential square bi-matrix games which have potential matrices that are two-way matrices are quadratically and symmetrically solvable games (i.e. there exists a square pay-off matrix whose expected pay-off maximizing probability vectors subject to the requirement that the two probability vectors (row probability vector and column probability vector) being equal) are equilibrium points of the bi-matrix game. We show by means of an example of a 2×2 identical symmetric potential bi-matrix game that for every potential matrix of the game, the set of pairs of probability distributions that maximizes the expected pay-off of the potential matrix is a strict subset of the set of equilibrium points of the potential game.
L2 Regularization Model with Removal of Gaussian Noise
Authors: Yuying Gou , Guicang Zhang , Genlian Han
Published: January 2023

In order to remove Gaussian noise from images, a Gaussian noise image restoration method based on the L2 norm regularization model was proposed. The L2 norm is selected as the data fidelity term and the gradient operator and wavelet frame as the regularization term to suppress the image ladder effect and protect the image edge details. Since the objective function of the model is a large convex function, the solving process is very tedious. The split Bregman iterative algorithm and alternate direction multiplier method are combined to restore the image. The experimental results show that show that the alternate direction multiplier method can effectively reduce the difficulty of solving the restoration model, and the image recovered by using this model has a higher peak signal-to-n ratio and better structural similarity and can get a clearer image.
On the Diophantine Equation (p+6)x - p y = z2 where p is a Prime Number with p ≡ 1 (mod 28)
Authors: Tadee Suton
Published: January 2023

This paper shows that the Diophantine equation (p+6)x - p y = z2 where p is a prime number with p ≡ 1 (mod 28), has a unique non-negative integer solution. The solution is ( , , ) (0,0,0) x y z = .
Digital Sociological Review of KP2C in the Use of Whatsapp Groups for Flood Mitigation
Authors: Faiz Sarvianto Dwiki , Kolopaking Lala M. , Hapsari Dwi Retno
Published: January 2023

KP2C has implemented a flood early warning system through Whatsapp groups since 2016. However, in the areas of Bojong Kulur and Jatirasa, which are the focus of KP2C information and downstream of the Cileungsi and Cikeas rivers, there are still losses for members. The interaction illustrates that achievement of KP2C’s goals has not been maximized, so the meaning of effectiveness is important to explored sociologically with variables thought to be related to it such as the digital divide, social structure’s form, and social capital’s level. This study uses a postpositivism paradigma and survey methods with data qualitative as a support. Respondents in this study were obtained by purposive technique with 40 individuals in RW 24 Bojong Kulur and RW 8 Jatirasa Village as affected areas. The results showed the majority of all variables were dominated by the medium category. Digital divide variable is strongly and positively related to social structure. Both are simultaneously also related to social capital. Therefore, it can be said that if the role of the early warning system is to be effective, then the three variables must clearly be considered.
Spirometric Values of Healthy School Children in Three Rural Schools of Bangladesh
Authors: Adnan Mohammad Ahad , Hossain Md Delwar , Habib Rahat Bin , Islam Tania , Khanam Wahida
Published: January 2023

Background: The prevalence of asthma in Bangladesh is about
7%. The spirometric values in healthy children were obtained in a
single urban school more than a decade ago. No rural data is available
till date. Objective: To determine the spirometric values of
healthy school going children in three rural schools of Bangladesh.
Materials and Methods: This cross-sectional study was carried
out from July 2019 to June 2020 among 300 healthy children among both
boys and girls aged 11 to 15 years in three rural schools. Among 350
approached students 332 students responded to the study, 18 students did
not meet inclusion criteria and 14 students could not follow spirometry
procedure. Informed written consent was taken from guardians. History
regarding socio-demographic profile, passive smoking, concurrent or past
respiratory illness and medication were taken and weight, height and BMI
were measured of the children. Spirometry was done with spirometer
machine and reports were generated by software installed in a laptop.
Results: Boys showed higher FVC, FEV1 and PEFR but lower
FEV1/FVC ratio than those of girls. Regression equations for lung
function values were determined for boys and girls considering height as
independent variable. Conclusions: Spirometric indices were
higher in boys than those of girls and they tended to increase with
height, except FEV1/FVC ratio that was higher in girls with a negative
correlation with height.
Diffuse alveolar hemorrhage, A rare complication of severe hypertension
Authors: Basrak Mohamad Talal , Alhammad Muhammad Firas , Anjum Shahzad , Ahmed Yasir Eltiraifi , Altermanini Mohammad
Published: January 2023

Severe hypertension is a rare cause of diffuse alveolar hemorrhage. We
reported a case of a 43-year-old lady who presented with shortness of
breath, hemoptysis and severe hypertension, patient was diagnosed with
diffuse alveolar hemorrhage due to severe hypertension and she improved
after controlling her blood pressure.
Soil filtration-sedimentation improves shelled protist discovery in eukaryotic eDNA surveys
Authors: Lentendu Guillaume , Bruni Estelle , Ah-Peng Claudine , Fujinuma Junichi , Kubota Yasuhiro , Lorite Juan , Peñas Julio , Huang Shuyin , Strasberg Dominique , Vittoz Pascal , Mitchell Edward
Published: January 2023

A large part of the soil protist diversity is missed in metabarcoding
studies based on 0.25 g of soil environmental DNA (eDNA) and universal
primers due to ca. 80 % co-amplification of non-target plants, animals
and fungi. To overcome this problem, enrichment of the substrate used
for eDNA extraction is an easyly implemented option but its effect has
not yet been tested. In this study, we evaluated the effect of a 150 µm
mesh size filtration and sedimentation method to improve the recovery of
protist eDNA, while reducing the co-extraction of plant, animal and
fungal eDNA, using a set of contrasted forest and alpine soils from La
Réunion, Japan, Spain and Switzerland. Biodiversity of the whole
eukaryotic community was estimated with V4 18S rRNA metabarcoding and
classical amplicon sequence variant calling. A 2-3-fold enrichment in
shelled protists (Euglyphida, Arcellinida and Chrysophyceae) was
observed at the sample level with the proposed method, with, at the same
time, a 2-fold depletion of Fungi and a 3-fold depletion of
Embryophyceae. Protist alpha diversity was slightly lower in filtered
samples due to reduced coverage in Variosea and Sarcomonadea, but
significant differences were observed in only one region. Beta diversity
was mostly impacted by region and habitat, and explained the same
variance in bulk soil and filtered samples. The increase resolution in
the soil protist diversity provided by the filtration-sedimentation
method is a strong argument to include it in the standard preparation of
any future soil for protist eDNA metabarcoding studies.
Bio-based Polymers containing traditional medicinal fillers for wound healing applications- An evaluation of Neoteric development and Future Perspectives
Authors: S HEMA , . Gayathri , Unni Vaani , B Niranjan , Chandran Smitha , Sambhudevan Sreedha
Published: January 2023

In recent years, health care providers have seen an increase in the
number of patients with difficult-to-treat wounds and burns. The bio
polymer-based wound dressing shields the injured part and aids in the
recapture of epithelial and dermal tissues throughout the process of
healing. The total count of a person with chronic lesions has been
expanding whole due to developing society, over weight and
cardiovascular illness. The development of ideal wound dressing material
with excellent characteristics like antimicrobial activity,
biocompatibility, free radical scavenging capacity, non-adherent
property, the hydrophilicity of alginate, cellulose, chitosan, collagen
has an increasing demand for the treatment of chronic wounds.
Nevertheless, owing to the above mention property, natural polymers are
being used for several key functions of biomedicine like narcotic
distribution systems, tissue manufacturing, bandages etc. accordingly,
the significance of these bio-based polymers interfered with healing
functions that lead to inform and inspire youth and scientist
researchers worldwide to grab with these far-reaching areas of medicine
and biology. The review highlights the physiochemical property of
natural polymer, biological evaluation of various materials as wound
dress, along with their synthesis and mechanical properties, clinical
status, challenges and future perspectives.
Alzheimer's disease- Pharmacotherapy, Immunotherapy and clinical trials in Immunotherapy
Authors: G Jefry Winner , Natarajan Anusha
Published: January 2023

Neurodegenerative disorders are common among the elderly. They possess a
tremendous therapeutic challenge for drug development and tackling the
disease. Alzheimer’s ranks as the most common neurodegenerative disease
affecting the elderly population. Developing therapeutics is still a
challenge despite advancements in the medical sciences. Replacing the
small molecules that are used for Alzheimer’s today, numerous Monoclonal
antibodies and vaccines are tried that targets explicitly the disease
pathology, either beta-amyloid or Tau aggregation. In this review, we
try to shed light on the existing small molecule therapeutics and the
recent advances with insights into Monoclonal antibodies and clinical
trials.
Systematically uncovering the absorbed effective substances of Radix scutellaria-licorice drug pair in rat plasma against COVID-19 using a combined UHPLC-Q-TOF-MS analysis and target network pharmacology
Authors: wen xuqing , xie weiwei , gao juan , zhang dedong , Yang Mengxin , Zhang Zhiqing , jin yiran , Du Yingfeng
Published: January 2023

Rationale: Radix scutellaria-Licorice drug pair (RSLDP), a frequently
used herbal pair with the effect of clearing heat and detoxifying, is
the commonly employed drug pair in TCM prescription for the treatment of
COVID-19. Until now, the metabolism feature and anti-COVID-19 mechanism
of RSLDP have not been fully elucidated. Methodology: In this study, a
sensitive and rapid method was developed for the separation and
identification of the absorbed constituents of RSLDP in the rat plasma
by UHPLC-QTOF-MS. Besides, we optimized the conventional process ways of
network pharmacology and proposed a new concept called target network
pharmacology (T-NP). It used the absorbed constituents and the
corresponding targets to generate compound-target network, and compare
to the conventional network pharmacology, it could reduce the false
positive results. Results: A total of 85 absorbed constituents were
identified or tentatively characterized in dosed plasma,including 32
components in Radix Scutellaria,27 components in Licorice and 65
components in RSLDP. The results showed that the compatibility of Radix
Scutellaria and Licorice increased the quantity of components in vivo.
We found that 106 potential targets of 64 active compounds in RSLDP were
related to COVID-19.And 12 targets (MAPK3,IL6,JUN,IL2,STAT3,
AKT1,TNF,STAT1,EGFR,HSP9AA1,VEGFA,RELA) could be core targets for RSLDP
in treating COVID-19. Conclusions: The metabolism feature of RSLDP in
vivo was systematically uncovered. The combining use of the T-NP method
could discover potential drug targets and disclose the biological
processes of RSLDP, which will clarify the potential mechanisms of RSLDP
in the treatment of COVID-19.
Privacy-Preserving Schemes of Distributed Sensor Networks with Dynamic Code
Authors: Chen Peipei , Liu Yun , Yang Wen
Published: January 2023

In this letter, we consider the privacy-preserving strategies of the
distributed state estimator over wireless sensor networks. Aiming at an
eavesdropper who can intercept the data transmitted on the communication
channel, we design a simple preserving scheme to encode the transmitted
data by using system dynamics and history estimates. To analyze the
privacy-preserving performance, we use the gap between the values
deciphered by the eavesdropper and decoded by the sensor as the privacy
index to evaluate the degree of robust privacy protection. Finally, we
provide some simulations to illustrate the effectiveness of the proposed
preserving schemes.
In silico prediction of immune-escaping hot spots for future COVID-19 vaccine design
Authors: Huang Sing-Han , Chen Yi-Ting , Lin Xiang-Yu , Ly Yi-Yi , Lien Ssu-Ting , Wang Cheng-Tang , Wu Suh-Chin , Chen Chwen-Cheng , Lin Ching-Yung
Published: January 2023

The COVID-19 pandemic has had a widespread impact on a global scale, and
the evolution of considerable dominants has already taken place. Some
variants contained certain key mutations located on the receptor binding
domain (RBD) of spike protein, such as E484K and N501Y. It is
increasingly worrying that these variants could impair the efficacy of
current vaccines or therapies. Therefore, how to design future vaccines
to prevent the different variants remains urgent. In this work, we
proposed an in silico approach, in which we combined binding free energy
measured by computational mutagenesis of spike-antibody complexes and
mutation frequency calculated from viral genome sequencing data, to
estimate an immune-escaping score ( IES) and predict
immune-escaping hot spots. We identified 23 immune-escaping mutations on
the RBD, nine of which occurred in omicron variants (R346K, K417N,
N440K, L452Q, L452R, S477N, T478K, F490S, and N501Y), despite our
dataset being curated before the omicron first appeared. The highest
immune-escaping score ( IES=1) was found for E484K, which agrees
with recent studies stating that the mutation significantly reduced the
efficacy of neutralization antibodies. Furthermore, our predicted
binding free energy and IES show a high correlation with
high-throughput deep mutational scanning (Pearson’s r = 0.70) and
experimentally measured neutralization titers data (mean Pearson’s
r = -0.80). In summary, our work provides valuable insights and
will help design future COVID-19 vaccines.
Gut microbiota: the indispensable player in neurological diseases
Authors: Li Sen , Wang Shuo , Luo Lei , Zhang Yu , Huang Kai , Guan Xiao
Published: January 2023

As one of the most urgent social and health problems in the world,
neurological diseases have always been attracted by researchers.
However, the pathological mechanisms and therapeutic approach are not
achieved. In addition to the established roles of oxidative stress,
inflammation and immune response, the changes of gut microbiota are also
closely related to the development of neurological diseases. Emerging
insights on the roles of gut microbiota have confirmed its
indispensability in the development of neurological diseases, including
neurodegenerative diseases and neuropsychiatric diseases. The dynamic
bidirectional communication pathway between gut microbiota and central
nervous system is called “gut-brain axis”, which involves immune,
metabolic and neural pathways. In this review, we discussed the complex
relationship between gut microbiota and the central nervous system from
the perspective of gut-brain axis, reviewed the mechanism of microbiota
in different neurological diseases, and prospected the employment of gut
microbiota in the therapeutic approach of those diseases.
RISK Factor Identification of COVID-19 Patients with Chronic Obstructive Pulmonary Disease
Authors: Hassan Muhammad Muneeb , Ameeq Muhammad , Jamal Farrukh , Tahir Muhammad H. , T John Mendy , Chesneau Christophe
Published: January 2023

Objectives: Chronic obstructive pulmonary disease (COPD)
affects a large part of the population around the world between the ages
forty-one to seventy-one years. However, by combining the effects of the
COVID-19 pandemic and the SARS-Cov-2 virus on COPD patients, we may be
able to overcome factors that have a significant impact on our success.
Moreover, we have to investigate the relationship between the diagnosis
and its influencing factors to possibly overcome the emerging causes of
this disease. Methods: A retrospective study of 280 patients
was conducted at DHQ Hospital Muzaffargarh in Punjab, Pakistan. Negative
binomial regression describes the risk of fixed successive variables.
Cox proportional hazard model, and the model co-efficient is observed
using log-likelihood. Kaplan-Meier curves showed how long COPD patients
survived or died. Results: The increased risk of death in COPD
patients was due to the effects of variables such as cough, lower
respiratory tract infection, tuberculosis, and body aches being 1.369,
0.693, 0.170, and 0.217 times higher, while it decreased by 0.396 in
normal conditions. Conclusion: We found that the symptoms of
COPD (cough, lower respiratory tract infection, tuberculosis, and body
aches) are statistically significant in patients who were most infected
by COVID-19 and SARS-Cov-2.
Runcinidae and Facelinidae: Two complete mitogenomes of understudied and misleading heterobranch families (Gastropoda, Mollusca)
Authors: Galià-Camps Carles , Araujo Ana Karla , Carmona Leila , Palero Ferran , Martín-Hervás María del Rosario , Pola Marta , Cervera Juan Lucas
Published: January 2023

Here, we present the mitochondrial sequences of two ‘opistobranch’
heterobranchs: Runcina aurata García-Gómez, López, Luque &
Cervera, 1986 and Facelina auriculata (O. F. Müller, 1776), the
latter type taxon of the genus. The mitochondrial genomes were 14,282
and 14,171bp in length respectively, the two of them with a complete set
of 13 CDS, 2 rRNAs, and 22 tRNAs. None of the mitogenomes showed gene
reorganization, keeping the standard heterobranch mitogenomic structure.
The base composition was completely distant between them, with a 25.7%
GC for R. aurata, becoming the mitogenome with more AT content to
the date, and 35% for F. auriculata, supposing one case of
extremely rich GC content in “opistobranch” mitochondrial genomes.
Effects of Environmental Stress Factors on the Actin Cytoskeleton of Fungi and Plants: Ionizing Radiation and ROS
Authors: Stephan Octavian O. H.
Published: January 2023

Actin is an abundant and multifaceted protein in eukaryotic cells that
has been detected in the cytoplasm as well as in the nucleus. In
cooperation with numerous interacting accessory-proteins, monomeric
actin (G-actin) polymerizes into microfilaments (F-actin) which
constitute ubiquitous subcellular higher order structures. Considering
the extensive spatial dimensions and multifunctionality of actin
super-arrays, the present study analyses the issue if and to what extent
environmental stress factors, specifically ionizing radiation (IR) and
reactive oxygen species (ROS), affect the cellular actin-entity. In that
context, this review particularly surveys IR-response of fungi and
plants. It examines in detail which actin-related cellular constituents
and molecular pathways are influenced by ionizing radiation and related
ROS. This comprehensive survey concludes that the general integrity of
the total cellular actin cytoskeleton is a requirement for IR-tolerance.
Actin´s functions in genome organization and nuclear events like
chromatin remodelling, DNA-repair, and transcription play a key role.
Beyond that, it is highly significant that the macromolecular
cytoplasmic and cortical actin-frameworks are affected by IR as well. In
response to IR, actin-filament bundling proteins (fimbrins) are required
to stabilize cables or patches. In addition, the actin-associated
factors mediating cellular polarity are essential for IR-survivability.
Moreover, it is concluded that a cellular homeostasis system comprising
ROS, ROS-scavengers, NADPH-oxidases, and the actin cytoskeleton plays an
essential role here. Consequently, besides the actin-fraction which
controls crucial genome-integrity, also the portion which facilitates
orderly cellular transport and polarized growth has to be maintained in
order to survive IR.
Future aspects of micro-plastics and their management
Authors: Archibong Ekong, Emem
Published: January 2023

Plastics are versatile materials of synthetic long-chain polymers with
low cost, lightweight, recalcitrant properties. The market is mostly
dominated by 6 classes of plastics:  Polyethylene (PE), Polypropylene
(PP), Polyvinyl Chloride (PVC), Polystyrene (PS), Poly-Urethane (PUR),
and Polyethylene Terephthalate (PET).  Microparticles as being in the
size range <5 mm (recognizing 333 μm as a practical lower
limit when neuston nets are used for sampling.  Microplastic pollution
has been a particular concern in recent years because of its prevalence
in the ocean and potential ingestion by marine organisms.  A sustainable
approach to both production and consumption of plastic materials with
global efforts has been geared towards the management of marine debris
via prevention. Recycling and reusing plastic products are some of the
most effective actions to reduce the volumes of plastic wastes that must
be flushed into the ocean. Finally, with the increase in microplastics
and its effects on marine ecosystems, it is suggested that community and
public vanguards could be initiated to develop a feasible platform for
microplastics’ mitigation and ecosystem balance.
Financial Access of Women-Owned Small and Medium-Sized Enterprises in Viet Nam
Authors: Bialus Diana , Tam Le Thanh , Nguyen Thi Thu Hien , Hong Minh Chu
Published: January 2023

This working paper identifies challenges in access to finance for women-owned small and medium-sized enterprises (SMEs) in Viet Nam and recommends ways to improve it. Out of 27 banks surveyed, the authors found that only 5 cater to the specific needs of SMEs owned by women. The paper proposes ways of incentivizing financial institutions to invest in this market segment. These include requiring gender-disaggregated data reporting, boosting knowledge on gender lens investing, improving guarantee schemes, and promoting lending to women-owned SMEs as an active hedge against portfolio deterioration. The paper recommends that financial institutions introduce regular tracking of gender-disaggregated data at portfolio level, design and implement gender lens strategies, and develop products and services better tailored to the needs and preferences of women-owned businesses.
Out-of-Pocket Costs in Alopecia Areata: A Cross-Sectional Study in German-speaking Countries
Authors: Kullab Johaina , Schielein Maximilian C. , Stuhlmann Caroline F.Z. , Tizek Linda , Wecker Hannah , Kain Alphina , Biedermann Tilo , Zink Alexander
Published: January 2023

Alopecia areata is a common skin disease which is associated with psychosocial and financial burden. No curative therapy exists and, hence, affected persons resort to self-financed cosmetic solutions. However, studies on the economic impact of alopecia areata on individuals are limited. To estimate annual individual out-of-pocket costs in persons with alopecia areata, a cross-sectional study using a standardized online questionnaire was performed in Germany, Austria and Switzerland. A total of 346 individuals (95.1% women, mean age: 38.5 ± 11.6 years) with alopecia areata participated between April and August 2020. Mean additional spending on everyday necessities was 1,248€ per person per year, which was significantly influenced by the duration of the illness, the treatment provider, and disease severity. Hair replacement products and cosmetics accounted for the highest monthly costs, followed by costs for physician visits, hospital treatments, and medication. Most participants (n = 255, 73.7%) were currently not undergoing treatment, due to lack of efficacy, side-effects, costs and acceptance of the disease. Sex differences in expenses were observed, with women having higher expenditures. Alopecia areata-related out-of-pocket costs place a considerable financial burden on affected individuals, are higher compared with those of other chronic diseases, and should be considered in economic assessments of the impact of this disease.
Siekierka kamienna z Bolkowa nad jeziorem Świdwie. Najstarszy ślad penetracji terenów nad dolną Odrą przez społeczności wczesnoneolityczne?
Authors: Galiński Tadeusz
Published: January 2023

W artykule omówiono znalezisko wczesnoneolitycznej siekierki kamiennej odkrytej w 2019 r. podczas badań wykopaliskowych na stanowisku mezolitycznym w Bolkowie na Pomorzu Zachodnim. Okaz wystąpił w warstwie datowanej serią 15 oznaczeń radiowęglowych na okres od 7870±50 BP do 7280±40 BP. Uwzględniając elementy paleotopograficzne i stratygraficzne znaleziska, jego wiek można określać na około 6200/6100 cal. BC. W świetle aktualnego stanu badań wyprzedza o pond 500 lat najstarsze zespoły kultury ceramiki wstęgowej na ziemiach polskich i w całej Europie Środkowej. Podobnie jak inne znaleziska tego typu znane z terenów Niemiec (Bad Dürrenberg), stanowi materialny ślad najstarszych penetracji północnych obszarów Niziny Europejskiej przez społeczności wczesnorolnicze z południa Europy.
Identifying Bronze Age glass production centres through bead-making techniques
Authors: Purowski Tomasz
Published: January 2023

The assemblage of Bronze Age glass beads found in the territory of present-day Poland counts 3100 pieces. The earliest examples known from excavations in central Europe are dated most often to the BrB–HaA1/A2 phases of the Bronze Age (= BA II–III/IV); they are made of high magnesium glass (HMG), which is now most frequently corroded. In the HaA2–HaB3 phases (= BA IV–V), beads were produced of a “mixed alkali” glass, also called low magnesium and high potassium glass (LMHK), which is usually preserved in rather good condition. The oldest beads are large as a rule, well made, using, at least in some cases, the folding technique. Small, undecorated beads made of “mixed alkali” glass were produced by the winding technique.
Między centrum, zapleczem a szlakiem handlowym. Wymiana i obieg pieniężny w tzw. ośrodkach centralnych we wczesnym średniowieczu na przykładzie Wrocławia
Authors: Pankiewicz Aleksandra
Published: January 2023

W artykule omówiono problem handlu i wymiany w głównych ośrodkach państwa Piastów na przykładzie Wrocławia. Podjęto próbę rewizji tras, którymi przebiegały okoliczne szlaki handlowe oraz odtworzenia ich zmienności w okresie od X do 1 poł. XIII w. Poruszono także kwestię roli handlu w kształtowaniu się samego Wrocławia, przy czym za istotne uznano pytanie, czy ośrodek ten, jak się powszechnie przypuszcza, powstał na skrzyżowaniu szlaków dalekosiężnych, czy też wzniesienie tego ważnego grodu stanowiło stymulator dla rozwoju lokalnych i ponadlokalnych połączeń drożnych. Przeanalizowano zarówno przedmioty związane z wymianą dóbr, jak i próbowano zlokalizować miejsca dokonywania ewentualnych transakcji. Na podstawie poszczególnych kategorii znalezisk (skarby srebrne, monety, wagi, odważniki etc.) ukazano przemiany dokonujące się w ekonomii grodu wrocławskiego i jego zaplecza.
Struktura spożycia mięsa w późnośredniowiecznym zamku w Sanoku (stan. 1, pow. sanocki, woj. podkarpackie)
Authors: Piątkowska-Małecka Joanna , Kotowicz Piotr
Published: January 2023

W artykule przedstawiono wyniki analizy archeozoologicznej zwierzęcych szczątków kostnych odkrytych w trakcie prac wykopaliskowych przeprowadzonych w 2011 r. na dziedzińcu zamku królewskiego w Sanoku. Badaniom poddano kości ssaków i ptaków pochodzące z nawarstwień datowanych od połowy XIV do początku XVI stulecia. Podstawę konsumpcji mięsa rezydentów sanockiego zamku stanowiła wołowina, uzupełniana wieprzowiną, baraniną i koziną, w niewielkim stopniu także mięsem zwierząt dzikich i ptactwa. Spożywano głównie wartościowe konsumpcyjnie części tuszy z łopatki i udźca, pochodzące od osobników zabijanych w młodym wieku, w większości samców.
GEODYNAMICS
Authors:   Design Institute of Security Service of Ukraine, Zhyrnov Pavlo
Published: January 2023

The article is aimed at conducting the engineering-construction assessment of Irpin town of Kyiv region. It is based on the engineering-geological zoning of the settlement, which provides the allocation of different-level taxonomic units with a set of natural and anthropogenic factors of construction conditions from the largest unit (engineering-geological region) to the smallest (sites and subsites). Engineering and geological surveying and mapping became the main research methods. The main result of the study was a comprehensive comparison of data on the geomorphological, geological-genetic structure, hydrogeological conditions, soils’ composition and properties of Irpin. It ultimately provided an opportunity to build a large-scale synthetic map of engineering-geological zoning and engineering- construction assessment of the town. The study identified eleven engineering-geological sites with appropriate characteristics of natural and anthropogenic factors of construction conditions factors, including have been identified, among which six sitesare unfavorable for construction. The scientific novelty of the above research lies in the application of engineering-geological zoning as a basis for engineering-construction assessment, which is not limited to the selection of planning restrictions of an engineering-geological nature. For the first time the novel method of engineering-geological subsites’ selection is based on the principle of taking into account natural hazards and morphometric characteristics of the relief. They reflect the degree of erosion dissection, potential for the of modern relief-forming processes’ manifestation and soil erosion. The practical aspect of the conducted research consists in creating a high-quality scheme of engineering-construction assessment, supplementing the scheme of existing planning restrictions, selecting optimal and economically justified measures for engineering preparation and territories’ protection against dangerous geological processes. Engineering-geological zoning allows you to determine safe places for the accomodation of engineering structures, their structural features, choose rational types of foundations, reduce the cost of survey and construction work and generally improve the design’s quality.
Perancangan Animasi 3D Tempat Wisata Pos Lintas Batas Negara antara Indonesia dan Papua Nugini
Authors: Marvel Arkha Tania  , Paulus Mudjihartono  , Patricia Ardanari
Published: January 2023

Abstrak. Perkembangan teknologi telah menyebabkan dampak besar dalam arti positif, salah satu bidang yang terdampak yaitu bidang multimedia. Berkat berkembangnya teknologi, multimedia yang semula menggunakan media fisik untuk memberikan informasi sudah berganti menjadi media digital. Perkembangan teknologi juga berdampak pada berkembangnya jaringan internet, sehingga informasi yang dikirimkan melalui internet dapat diakses oleh masyarakat secara mudah dan efisien. Penggunaan multimedia seiring dengan perkembangan zaman dapat digunakan untuk mempromosikan atau memperkenalkan suatu tempat atau daerah, contohnya adalah penggunaan simulasi 3D mengenai tempat wisata yang berada di Pos Lintas Batas Negara (PLBN) Skouw Jayapura, Papua. Simulasi 3D dapat memproyeksikan dengan baik dan jelas tentang gambaran dari bangunan dan objek wisata yang berada di PLBN. Berdasarkan pengujian yang dilakukan menggunakan proses wawancara dan kuesioner mengenai penerapan animasi dalam bentuk simulasi 3D ini, diperoleh hasil bahwa 70% responden sudah merasa sesuai dengan mekanisme pada simulasi dan 60% responden sudah merasa cukup puas mengenai simulasi secara keseluruhan.Kata Kunci: Teknologi, Simulasi 3D, PLBN Skouw, Tempat Wisata.
Rancang Bangun Aplikasi Pengolahan Data Transaksi Bengkel Berbasis Desktop
Authors: Kevin Septianto Waluyo  , Suyoto  , Joanna Ardhyanti Mita Nugraha
Published: January 2023

Abstrak. Di era teknologi komputer dan informasi ini merancang suatu aplikasi berbasis desktop dapat dilakukan. Desktop merupakan Aplikasi yang dapat di jalankan di desktop menggunakan komputer maupun laptop pengguna. Aplikasi Desktop juga dapat digunakan untuk mengolah berbagai data agar data tersebut lebih mudah di akses untuk mendapatkan informasinya. Bengkel bernama Citras Jaya Service ini masih menggunakan kertas untuk mencatat berbagai data secara manual yang membuat pemilik dari bengkel kesusahan untuk mencari atau memeriksa data terutama data transaksi. Aplikasi pengolahan data berbasis desktop dapat membantu mengolah data penting bengkel dan mencetak laporan transaksi sekaligus mencari data penting bengkel lebih efektif dan efisien agar pemilik bengkel tidak kesusahan dalam mencari data. Hasil yang di dapat dari penelitian ini, aplikasi Citras Jaya Service yang berbasis desktop ini dapat mempermudah pengguna untuk mengelola data dan melakukan proses transaksi melalui aplikasi.Kata Kunci: Bengkel, Aplikasi, Desktop, Pengolahan Data.
Pengujian Website EPOS PT XYZ Menggunakan Metode Black Box Testing
Authors: Wendy Winata  , Andi Wahju Rahardjo Emanuel  , Herlina
Published: January 2023

Abstrak. PT XYZ merupakan salah satu perusahaan yang mengadopsi website untuk membantu produktivitas bisnisnya. Oleh karena itu, website yang digunakan memerlukan pengujian terlebih dahulu untuk memastikan fungsionalitas website dapat berjalan sesuai dengan tujuan dan terhindar dari bug atau masalah. Penelitian ini berfokus dalam melakukan pengujian pada website secara manual dan otomatis, menggunakan metode black box testing dan teknik equivalence partitioning. Pengujian akan dimulai dengan membangun test case terlebih dahulu agar bisa mendapatkan hasil yang terstruktur dan terarah. Hasil dari pengujian akan digunakan untuk melihat bagaimana presentase keberhasilan dari fungsionalitas yang ada pada website. Selain mendapatkan presentase keberhasilan dari pengujian, penelitian ini juga akan melihat bagaimana kelebihan dan kekurangan dari pengujian otomatis dan pengujian manual berdasarkan beberapa parameter perbandingan.Kata Kunci: Pengujian, Black Box Testing, Equivalence Partitioning, Pengujian Otomatis, Pengujian Manual