bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-Border Shopping and Employment Patterns in the Southwestern United States
Authors: Fullerton Thomas M. , Walke Adam G.
Published: December 2019

Price differentials, among other factors, persuade many residents of Northern Mexico to shop in the Southwestern United States border region. Employment patterns in the latter region are studied using a set of control variables and two indicators that are likely to influence cross-border shopping patterns. The first is a real exchange rate index, which captures changes in relative prices in the United States and Mexico. The second is real per capita gross state product in Mexican states adjacent to the international boundary. Both of these variables are found to impact retail and restaurant employment in the United States border zone, confirming that cross-border shopping influences labor market conditions in that region. Furthermore, the estimated elasticities vary across retail sub-sectors in ways that are generally consistent with prior research. Overall, the results suggest that economic setbacks in Northern Mexico and real peso depreciations are likely to have adverse consequences for important sectors of border economies in the United States.
A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem
Authors: Sachithanandam V. , Lalitha P. , Parthiban A. , Mageswaran T. , Manmadhan K. , Sridhar R.
Published: December 2019

Mangrove ecosystem has many potential species that are traditionally used by the coastal communities for their traditional cure for health ailments as evidenced by their extensive uses to treat hepatic disorders, diabetes, gastrointestinal disorders, anti-inflammation, anticancer, and skin diseases, etc. In recent times, the diabetes mellitus (DM), a serious physiological disorder all over the world, occur due to the relative or complete deficiency of insulin in the body, characterized by an abnormally high blood glucose level. India has a rich traditional knowledge on plant-based drug formulations that are protective and curative for many health ailments. In this context, we aimed to compile the works done on the antidiabetic activities of mangrove species from Indian coastal regions especially on Andaman and Nicobar Islands as well as some recent works reported from other countries. A total of 126 published articles and 31 mangrove species related pieces of information were gathered with reference to antidiabetic properties of mangroves. This review summarizes the chemical structures, molecular formula, molecular weight, and their biological activities with an aspiration that it might be helpful for the future bioprospecting industries who are interested in develop the natural drugs for DM.
A Rare Case of Intracardiac Extension of Hepatocellular Carcinoma in a Child
Authors: Al Jassmi Abdulrahman , Humad Hani , Eida Said Abou
Published: December 2019

Hepatocellular carcinoma (HCC) is the fifth most common malignancy found in men and ninth most common in women, out of which 72.5% reported cases are from Asia. In children, it accounts for <2% cases worldwide with even rarer incidence of 1.2% involving intracardial extension. However, it presents with a high mortality rate with mean survival ranging from 1 to 4 months. The present case is an extremely rare case of intracardiac extension of HCC in a 3.5-year-old Asian girl with no history of hepatitis B infection presented at an advanced stage of HCC who succumbed within one month of presentation to the hospital.
Aqueous and Methanol Extracts of Paullinia pinnata (Sapindaceae) Improve Monosodium Urate-Induced Gouty Arthritis in Rat: Analgesic, Anti-Inflammatory, and Antioxidant Effects
Authors: Tseuguem Pius Pum , Nguelefack Télesphore Benoît , Piégang Basile Ngnanmegne , Mbankou Ngassam Sorelle
Published: December 2019

The profound modification of lifestyle and food habits has led to an important increase in the prevalence of gout. Unfortunately, there are current unmet needs for the treatment of this disease, prompting the search for new alternatives. Paullinia pinnata is a plant used to treat various diseases including arthritis. The present work aimed to investigate the antigouty activities of the aqueous (AEPP) and methanolic (MEPP) extracts of P. pinnata as well as their in vivo antioxidant properties. The gouty arthritis was induced by injecting 50 μl of monosodium urate (MSU, 100 mg/ml) in the left hind ankle of rats. P. pinnata extracts were administered orally at the doses of 100 and 200 mg/kg/day for 6 days, starting 24 h after MSU injection. Allopurinol 5 mg/kg/day was used as reference drug. Inflammation and hyperalgesia were daily monitored from 24 hours after treatment initiation and for the 6 consecutive days. Myeloperoxidase (MPO) quantification was done in collected synovial fluid. Nitrite oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) were evaluated in the spinal cord and the brain. The serum content of SOD was additionally quantified. AEPP and MEPP significantly (p<0.001) reduce MSU-induced inflammation (22.41% to 93.65%) and hyperalgesia (33.33% to 64.44%) in both ankle and paw. AEPP and MEPP significantly (p<0.001) reduce synovial MPO production with the percentage ranging from 76.30% to 85.19%. AEPP and MEPP significantly (p < 0.001) reduce serum, spinal, left and right hemispheres NO, and MDA and increase the SOD activity (p<0.001). P. pinnata leaf extracts possess potent curative effects against MSU-induced gouty arthritis that combines analgesic, anti-inflammatory, and antioxidant activities. These findings support the use of P. pinnata leaves extracts in the treatment of gouty arthritis and further present the plant as a potent source of efficient antigouty medicine.
A New Approach to Shortest Route Finding in a Railway Network with Two Track Gauges and Gauge Changeovers
Authors: Almech Alberto , Roanes-Lozano Eugenio , Solano-Macías Carmen , Hernando Antonio
Published: December 2019

The Spanish railway network is a complex one, due to the existence of standard gauge (1,435 mm), Iberian gauge (1,668 mm), and dual gauge (with three rails) subnetworks, as well as connections between the two first subnetworks (at the so‐called gauge changeovers), usable by dual gauge trains. Two of the authors developed a package for shortest route finding, and consumes, costs, and emissions calculations in the Spanish railway network (within the frame of two research projects funded by the Fundación de los Ferrocarriles Españoles–Spanish Railways Foundation). Nevertheless, the approach required from a curious specific algorithm to be developed ad hoc. In this paper, a much simpler approach to shortest route finding in such a network, which merges the three subnetworks into two and considers the gauge changeovers as connections between the two new subnetworks, is detailed. This approach allows to use any standard shortest route algorithm. It has been implemented in the computer algebra system Maple and is applied in this paper both to small specific cases and to the whole Spanish railway network.
Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats
Authors: Ekanayake C. P. , Thammitiyagodage M. G. , Padumadasa S. , Seneviratne B. , Padumadasa C. , Abeysekera A.M.
Published: December 2019

Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.
Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model
Authors: Murando Federica , Peloso Andrea , Cobianchi Lorenzo
Published: December 2019

Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes.
Anticancer Activity of ZnO Nanoparticles against Human Small-Cell Lung Cancer in an Orthotopic Mouse Model
Authors: Tanino Ryosuke , Amano Yoshihiro , Tong Xuexia , Sun Rong , Tsubata Yukari , Harada Mamoru , Fujita Yasuhisa , Isobe Takeshi
Published: November 2019

Small-cell lung cancer, a highly malignant form of lung cancer, often responds to first-line treatments but relapses in most cases with resistance to further treatments. We tested zinc oxide (ZnO) nanoparticles against small-cell lung cancer and other cancer cell lines, in light of reported anticancer effects in vitro. Because of a strong safety record, ZnO nanoparticles are frequently used in biomedical research, including in cellular imaging and drug delivery, and have been used for many years in several commercial products such as skin care agents. Strikingly, ZnO nanoparticles were genotoxic against small-cell lung cancer cells, resulting in low viability, even in cells orthotopically grafted onto mouse models. However, the nanoparticles were less cytotoxic against normal lung–derived cells and did not elicit observable adverse effects after intravenous administration. ZnO nanoparticles were also found to induce highly reactive oxygen species and DNA leakage from nuclei. This study is the first comprehensive evaluation of the anticancer effects of ZnO nanoparticles in vitro and in vivo and highlights new therapeutic opportunities against small-cell lung cancer.
A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical–Genetic High-Content Phenotypic Screen
Authors: Dawson John C. , Serrels Bryan , Byron Adam , Muir Morwenna T. , Makda Ashraff , García-Muñoz Amaya , von Kriegsheim Alex , Lietha Daniel , Carragher Neil O. , Frame Margaret C.
Published: November 2019

We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We reexpressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which endogenous FAK had been deleted, genetically fixing one axis of a FAK inhibitor combination high-content phenotypic screen to discover drugs that may synergize with FAK inhibitors. Histone deacetylase (HDAC) inhibitors represented the major class of compounds that potently induced multiparametric phenotypic changes when FAK was rendered kinase-defective or inhibited pharmacologically in SCC cells. Combined FAK and HDAC inhibitors arrest proliferation and induce apoptosis in a subset of cancer cell lines in vitro and efficiently inhibit their growth as tumors in vivo. Mechanistically, HDAC inhibitors potentiate inhibitor-induced FAK inactivation and impair FAK-associated nuclear YAP in sensitive cancer cell lines. Here, we report the discovery of a new, clinically actionable, synergistic combination between FAK and HDAC inhibitors.
A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer–Induced Osteolytic Bone Resorption
Authors: Pore Subrata K. , Hahm Eun-Ryeong , Kim Su-Hyeong , Singh Krishna B. , Nyiranshuti Lea , Latoche Joseph D. , Anderson Carolyn J. , Adamik Juraj , Galson Deborah L. , Weiss Kurt R. , Watters Rebecca J. , Lee Boeun , Kumta Prashant N. , Singh Shivendra V.
Published: November 2019

Bone is the most preferred site for colonization of metastatic breast cancer cells for each subtype of the disease. The standard of therapeutic care for breast cancer patients with bone metastasis includes bisphosphonates (e.g., zoledronic acid), which have poor oral bioavailability, and a humanized antibody (denosumab). However, these therapies are palliative, and a subset of patients still develop new bone lesions and/or experience serious adverse effects. Therefore, a safe and orally bioavailable intervention for therapy of osteolytic bone resorption is still a clinically unmet need. This study demonstrates suppression of breast cancer–induced bone resorption by a small molecule (sulforaphane, SFN) that is safe clinically and orally bioavailable. In vitro osteoclast differentiation was inhibited in a dose-dependent manner upon addition of conditioned media from SFN-treated breast cancer cells representative of different subtypes. Targeted microarrays coupled with interrogation of The Cancer Genome Atlas data set revealed a novel SFN-regulated gene signature involving cross-regulation of runt-related transcription factor 2 (RUNX2) and nuclear factor-κB and their downstream effectors. Both RUNX2 and p65/p50 expression were higher in human breast cancer tissues compared with normal mammary tissues. RUNX2 was recruited at the promotor of NFKB1. Inhibition of osteoclast differentiation by SFN was augmented by doxycycline-inducible stable knockdown of RUNX2. Oral SFN administration significantly increased the percentage of bone volume/total volume of affected bones in the intracardiac MDA-MB-231-Luc model indicating in vivo suppression of osteolytic bone resorption by SFN. These results indicate that SFN is a novel inhibitor of breast cancer–induced osteolytic bone resorption in vitro and in vivo.
Introduction of Noninvasive Prenatal Testing for Blood Group and Platelet Antigens from Cell-Free Plasma DNA Using Digital PCR
Authors: Eryilmaz Marion , Müller Dennis , Rink Gabi , Klüter Harald , Bugert Peter
Published: December 2019

Background: Noninvasive prenatal testing (NIPT) for fetal antigens is a common standard for targeted immune prophylaxis in RhD-mediated hemolytic disease of the fetus and newborn, and is most frequently done by quantitative PCR (qPCR). A similar approach is considered for other blood group and human platelet alloantigens (HPA). Because of a higher sensitivity compared to qPCR for rare molecule detection, we established and validated digital PCR (dPCR) assays for the detection of RHD exons 3, 5 and 7, KEL1, HPA-1a, and HPA-5b from cell-free DNA (cfDNA) in plasma. The dPCR assays for the Y-chromosomal marker amelogenin and autosomal SNPs were implemented as controls for the proof of fetal DNA. Methods: Validation was performed on dilution series of mixed plasma samples from volunteer donors with known genotypes. After preamplification of the target loci, two-color (FAM and VIC) TaqManTM probe chemistry and chip-based dPCR were applied. The assays for RHD included GAPDH as an internal control. For the diallelic markers KEL1/2, HPA-1a/b, HPA-5a/b, and AMEL-X/Y and 3 autosomal SNPs, the probes enabled allelic discrimination in the two fluorescence channels. The dPCR protocol for NIPT was applied to plasma samples from pregnant women. Results: The RHD exon 5 assay allowed the detection of a 0.05% RHD target in an RhD-negative background, whereas the exon 7 assay required at least a 0.25% target. The exon 3 assay showed the highest background and required at least a 2.5% RHD target for reliable detection. The dPCR assays for the diallelic markers revealed similar sensitivity and enabled the detection of at least a 0.5% target allele. The HPA-1a assay was the most sensitive and allowed target detection in plasma mixtures containing only 0.05% HPA-1a. The plasma samples from 13 pregnant women at different gestational ages showed unambiguous positive and negative results for the analyzed targets. Conclusion: Analysis of cfDNA from maternal plasma using dPCR is suitable for the detection of fetal alleles. Because of the high sensitivity of the assays, the NIPT protocol for RhD, KEL1, and HPA can also be applied to earlier stages of pregnancy.
The Life Cycle of Dictyostelium discoideum Is Accelerated via MAP Kinase Cascade by a Culture Extract Produced by a Synthetic Microbial Consortium
Authors: Kuwayama Hidekazu , Higashinakagawa Toru
Published: December 2019

A cellular slime mold, Dictyostelium discoideum, is an amoeboid organism that has a unique life cycle consisting of distinctly separated vegetative and developmental phases. Thus, this organism presents a rare opportunity in which to examine the effects of bioactive substances on separate cellular activities. In this research, we investigated the effect of a culture extract, termed EMXG, produced by a synthetic microbial consortium. EMXG promoted proliferative response of amoeba cells. It further accelerated the developmental phase, leading to the preferred fruiting body formation from fewer cells. Furthermore, EMXG modulated biological rhythm of this organism, that is, interval of oscillation of cAMP level observed in suspension starvation was significantly shortened. Concomitantly, the level of ERKB, a MAP kinase, was found to oscillate in a similar fashion to that of cAMP. Additionally, ErkB-deficient mutant amoeboid cells did not respond to proliferative stimulation by EMXG. These lines of evidence point to a likelihood that MAP kinase cascade is involved and further that ErkB could be the molecular target of EMXG.
Effectiveness of Prompt Mental Health Care, the Norwegian Version of Improving Access to Psychological Therapies: A Randomized Controlled Trial
Authors: Knapstad Marit , Lervik Linn Vathne , Sæther Solbjørg Makalani Myrtveit , Aarø Leif Edvard , Smith Otto Robert F.
Published: December 2019

Background: The innovative treatment model Improving Access to Psychological Therapies (IAPT) and its Norwegian adaptation, Prompt Mental Health Care (PMHC), have been evaluated by cohort studies only. Albeit yielding promising results, the extent to which these are attributable to the treatment thus remains unsettled. Objective: To investigate the effectiveness of the PMHC treatment compared to treatment as usual (TAU) at 6-month follow-up. Methods: A randomized controlled trial with parallel assignment was performed in two PMHC sites (Sandnes and Kristiansand) and enrolled clients between November 9, 2015 and August 31, 2017. Participants were 681 adults (aged ≥18 years) considered for admission to PMHC due to anxiety and/or mild to moderate depression (Patient Health Questionnaire [PHQ-9]/Generalized Anxiety Disorder scale [GAD-7] scores above cutoff). These were randomly assigned (70:30 ratio; n = 463 to PMHC, n = 218 to TAU) with simple randomization within each site with no further constraints. The main outcomes were recovery rates and changes in symptoms of depression (PHQ-9) and anxiety (GAD-7) between baseline and follow-up. Primary outcome data were available for 73/67% in PMHC/TAU. Sensitivity analyses based on observed patterns of missingness were also conducted. Secondary outcomes were work participation, functional status, health-related quality of life, and mental well-being. Results: A reliable recovery rate of 58.5% was observed in the PMHC group and of 31.9% in the TAU group, equaling a between-group effect size of 0.61 (95% CI 0.37 to 0.85, p < 0.001). The differences in degree of improvement between PMHC and TAU yielded an effect size of –0.88 (95% CI –1.23 to –0.43, p < 0.001) for PHQ-9 and –0.60 (95% CI –0.90 to –0.30, p < 0.001) for GAD-7 in favor of PMHC. All sensitivity analyses pointed in the same direction, with small variations in point estimates. Findings were slightly more robust for depressive than anxiety symptoms. PMHC was also more effective than TAU in improving all secondary outcomes, except for work participation (z = 0.415, p = 0.69). Conclusions: The PMHC treatment was substantially more effective than TAU in alleviating the burden of anxiety and depression. This adaptation of IAPT is considered a viable supplement to existing health services to increase access to effective treatment for adults who suffer from anxiety and mild to moderate depression. A potential effect on work participation needs further examination.
The Association of Partial Azoospermia Factor C Deletions and Male Infertility in Northwestern China
Authors: Liu Chunlian , Zhao Xinyan , Mu Chunlan , Li Hui , Ma Jia , Jiao Haiyan , Huo Zhenghao
Published: December 2019

Background: Male infertility is a major health issue worldwide. Y chromosome microdeletions are well-characterized genetic causes of male infertility. The association of partial AZFc deletions (gr/gr, b2/b3, and b1/b3) with male infertility is not well confirmed in diverse populations. The purpose of the present study was to investigate the frequency of partial AZFc deletions and their association with male infertility in a population from Northwestern China. Methods: Multiplex polymerase chain reaction was used to detect partial AZFc deletions in 228 infertile patients. We analyzed 141 cases of azoospermia (AS), 87 cases of oligozoospermia (OS), and 200 fertile controls. Results: Our data showed that the frequency of a b2/b3 deletion in infertile men, men with AS, men with OS, and controls was 3.51, 2.13, 5.75, and 0.00%, respectively. The frequency of this deletion was significantly different between the infertile group and the control group (3.51 vs. 0.00%, respectively, p = 0.021) and between the OS group and the control group (5.75 vs. 0.00%, respectively, p = 0.003). The frequency of a gr/gr deletion in each group was 11.84, 9.22, 16.09, and 7.50%, respectively. The frequency of a gr/gr deletion was significantly different between the OS group and the control group (16.09 vs. 7.50%, respectively, p = 0.026) but not between the infertile group and the control group (11.84 vs. 7.50%, p = 0.132) or the AS group and the control group (9.22 vs. 7.50%, p = 0.569). The frequency of a b1/b3 deletion was 0.44, 0.71, 0.00, and 3.00%, respectively. For this deletion, there was no significant difference between the infertile (0.44 vs. 3.00%, p = 0.089), AS (0.71 vs. 3.00%, p = 0.276), and OS groups (0.00 vs. 3.00%, p = 0.236) and the control group. Conclusions: Our results suggest that the b2/b3 deletion might be associated with male infertility and that the gr/gr deletion might be associated with spermatogenic failure in men with OS in Northwestern China (Ningxia).
Endogenous Heparin-Like Substances May Cause Coagulopathy in a Patient with Severe Postpartum Hemorrhage
Authors: Wang Shichun , Qi Chao , Liu Zhicheng , Xu Ting , Yao Chunyan
Published: December 2019

Introduction: Postpartum hemorrhage (PPH) is associated with maternal morbidity and mortality. Accurate diagnosis of the cause of puerperal hemorrhage is as important as treatment strategies for resuscitation. We report a case of coagulation disorder caused by endogenous heparin-like substances in a PPH patient. Case Presentation: A 30-year-old woman with no medical history of bleeding disorders suffered intractable hemorrhage following spontaneous delivery in a local hospital. The patient was transferred to the department of obstetrics of a superior hospital. On arrival, the patient was found to have severe hemorrhagic anemia, hemorrhagic shock, and disseminated intravascular coagulation. Active treatments were performed, but the patient continued bleeding. Laboratory testing, performed during early treatment, revealed that all coagulation factors were below normal. The differences between CK-TEG R-time (reaction time in citrated kaolin thromboelastography assay) and CKH-TEG R-time (reaction time in citrated kaolin with heparinase thromboelastography assay) suggested the presence of heparin activity. However, the patient’s family denied heparin use prior to presentation. Thus, we deduced that endogenous heparin-like substances were the main cause of the coagulopathy. After receiving treatment with protamine, the patient stopped bleeding. Meanwhile, all coagulation parameters and the TEG assay results improved. Conclusions: In this case report, TEG assay suggested the presence of heparin activity in a PPH patient, and treatment also highlighted the importance of analyzing different parameters in TEG.
Lucas Galon’s Concerto for Violin, Percussion and Strings (2018)
Authors: Palmezano Ricardo Alex
Published: December 2019

In this paper, I investigate how the composer searches for his own voice in his violin concerto while using a blend of influences such as Bartok, twelve-tone and Brazilian popular music. Galon argues that composers such as Bartok, Stravinsky and Villa-Lobos followed an independent, more varied compositional style without subscribing to any specific method.[1]On the other hand, the self-proclaimed mainstream of the Second Viennese School established a very structured, particular way of writing music. The composer seems to put into question the mechanization of composition of the dodecaphonic method, but validates its use as a way of refraining his creative impulse.[2]While Bartok’s Violin Concerto No. 2provides a framework for his piece; the tools he uses to manipulate the musical material are drawn from a free use of serialism and Brazilian contemporary music philosophy and aesthetic.
Carotid Intima-Media Thickness
Authors: Strawbridge Rona J. , Ward Joey , Bailey Mark E.S. , Cullen Breda , Ferguson Amy , Graham Nicholas , Johnston Keira J.A. , Lyall Laura M. , Pearsall Robert , Pell Jill , Shaw Richard J. , Tank Rachana , Lyall Donald M. , Smith Daniel J.
Published: December 2019

Objective:

Atherosclerosis is the underlying cause of most cardiovascular disease, but mechanisms underlying atherosclerosis are incompletely understood. Ultrasound measurement of the carotid intima-media thickness (cIMT) can be used to measure vascular remodeling, which is indicative of atherosclerosis. Genome-wide association studies have identified many genetic loci associated with cIMT, but heterogeneity of measurements collected by many small cohorts have been a major limitation in these efforts. Here, we conducted genome-wide association analyses in UKB (UK Biobank; N=22 179), the largest single study with consistent cIMT measurements.

Approach and Results:

We used BOLT-LMM software to run linear regression of cIMT in UKB, adjusted for age, sex, and genotyping chip. In white British participants, we identified 5 novel loci associated with cIMT and replicated most previously reported loci. In the first sex-specific analyses of cIMT, we identified a locus on chromosome 5, associated with cIMT in women only and highlight
VCAN
as a good candidate gene at this locus. Genetic correlations with body mass index and glucometabolic traits were also observed. Two loci influenced risk of ischemic heart disease.

ConclusionS:

These findings replicate previously reported associations, highlight novel biology, and provide new directions for investigating the sex differences observed in cardiovascular disease presentation and progression.
Integrative Omics Approach to Identifying Genes Associated With Atrial Fibrillation
Authors: Wang Biqi , Lunetta Kathryn L. , Dupuis Josée , Lubitz Steven A. , Trinquart Ludovic , Yao Lixia , Ellinor Patrick T. , Benjamin Emelia J. , Lin Honghuang
Published: December 2019

Rationale:

GWAS (Genome-Wide Association Studies) have identified hundreds of genetic loci associated with atrial fibrillation (AF). However, these loci explain only a small proportion of AF heritability.

Objective:

To develop an approach to identify additional AF-related genes by integrating multiple omics data.

Methods and Results:

Three types of omics data were integrated: (1) summary statistics from the AFGen 2017 GWAS; (2) a whole blood EWAS (Epigenome-Wide Association Study) of AF; and (3) a whole blood TWAS (Transcriptome-Wide Association Study) of AF. The variant-level GWAS results were collapsed into gene-level associations using fast set-based association analysis. The CpG-level EWAS results were also collapsed into gene-level associations by an adapted SNP-set Kernel Association Test approach. Both GWAS and EWAS gene-based associations were then meta-analyzed with TWAS using a fixed-effects model weighted by the sample size of each data set. A tissue-specific network was subsequently constructed using the NetWAS (Network-Wide Association Study). The identified genes were then compared with the AFGen 2018 GWAS that contained more than triple the number of AF cases compared with AFGen 2017 GWAS. We observed that the multiomics approach identified many more relevant AF-related genes than using AFGen 2018 GWAS alone (1931 versus 206 genes). Many of these genes are involved in the development and regulation of heart- and muscle-related biological processes. Moreover, the gene set identified by multiomics approach explained much more AF variance than those identified by GWAS alone (10.4% versus 3.5%).

Conclusions:

We developed a strategy to integrate multiple omics data to identify AF-related genes. Our integrative approach may be useful to improve the power of traditional GWAS, which might be particularly useful for rare traits and diseases with limited sample size.
Description of Longidorus barsii Radivojević & De Luca sp. n. (Nematoda: Longidoridae) from Serbia and observations on some taxonomic characters
Authors: Radivojević Milan , Barsi László , Fanelli Elena , De Luca Francesca
Published: November 2019

Longidorus barsii sp. n., from Mt Tara in the Balkan Peninsula, is described and characterised by using a polyphasic approach. The species has numerous males. The female body is 5-7 mm long, rather stout and resembles a large Xiphinema. The lip region is wide, with rounded sides continuous with the neck, frontally flattened and depressed around the oral aperture, amphids are pouch-like and distinctly bi-lobed and the odontostyle is moderately long. The nuclei of the pharyngeal glands are in the normal position, the dorsal nucleus located somewhat posterior to anterior third of bulb. The uteri are long, the distal inner epithelium densely covered with papilla-like outgrowths. The tail is rounded, bluntly conoid and very short. Alpha-numerical identification codes: A4/5, B45, C3, D3, E2, F3, G 1(2), H1, I2, J1, K67. The morphologically most similar species are L. kheirii, L. polyae and L. profundorum. Additional observations are provided on the anterior body region and genital organs in L. barsii sp. n., L. piceicola, L. silvae, and L. uroshis. Selected features are discussed from the taxonomic and functional points of view. The D2-D3 expansion domains of the 28S rRNA gene and the ITS region of L. barsii sp. n. were amplified and sequenced. Phylogenetic analysis using the D2-D3 expansion domains of the 28S rRNA gene revealed close evolutionary relationships with L. polyae, L. athesinus and three unidentified Longidorus spp.
Marxism, Structuralism and Psychoanalysis
Authors: Starcenbaum Marcelo
Published: November 2019

Althusser’s reception within Argentinian psychoanalytic culture assumed a variety of different forms. For the purposes of delimiting mediations between Marxism, structuralism and psychoanalysis in Argentina during the 1960s and ’70s, this work seeks to reconstruct historical readings of Althusser according to his reception within three distinct interpretative communities. The first group, centring on the figure of Oscar Masotta, concerns Althusser’s role in the development of Argentina’s incipient Lacanian groups. For the second group, primarily dissident-psychoanalytic and Freudo-Marxist, the reception of Althusser will be considered in tandem with ensuing debates between Freudo-Marxism and Althussero-Lacanism. The third group asks us to consider the role of Althusserianism in discussions around the professionalisation of psychology, where the careers of Carlos Sastre and Roberto Harari showed the strongest connections to Althusser’s work.
Contradictions of the Labour Process, Worker Empowerment and Capitalist Inefficiency
Authors: Vidal Matt
Published: November 2019

I articulate a classical-Marxist theory of technical change in the capitalist labour process, highlighting two contradictions. The management contradiction is the conflict managers experience between coordination (to increase efficiency) and discipline (to ensure valorisation). The workforce contradiction is the tension workers experience between productive socialisation and alienation. I submit that both contradictions were substantially muted from the earliest stages of capitalism through the Fordist stage but have become intensified in the postfordist period. Under postfordism, the basis of efficiency is economies of scope and flexibility, and thus there is a real efficiency advantage to empowering workers, via both multiskilling and employee involvement in problem-solving and decision-making. Postfordist capitalism has thus initiated an intensification of the management and workforce contradictions. In response, capitalist management is increasingly impeding the growth of the productive forces by failing to empower workers.
First Person Thoughts: Shareability and Symmetry
Authors: Bermúdez José Luis
Published: November 2019

Victor Verdejo’s paper ‘On Having the Same First Person Thoughts’ introduces an interesting and fruitful framework for applying the type-token distinction to first person thoughts. He draws a three-way distinction between types, instantiable types, and instantiated types, and uses that distinction to open up a conceptual space for the possibility of shareable first person thoughts. This note distinguishes two types of interpersonal shareability and argues that Verdejo’s suggestions about instantiable types can only secure shareability of the first kind, but not the second. The author then shows how his own account of what he terms the token-sense of “I” (Bermúdez 2011 and 2017) succeeds in making possible this second type of interpersonal shareability, despite the criticisms in Verdejo’s paper.
Inconsistency without Irrationality
Authors: Weber Konstantin
Published: November 2019

Every theory of rationality worth taking seriously implies that it is in some way irrational to accept contradictions. In this essay, the author examines how exactly this basic idea should be spelled out. He argues for two claims. First, it is not practically irrational to accept a contradiction in the sense of causing oneself to have contradictory beliefs. Second, it is moreover not theoretically irrational to accept a contradiction in the sense of having contradictory beliefs, if the contradictoriness of the relevant beliefs is inaccessible to the person. The contradictoriness of a set of beliefs is accessible to a person only if this person possesses the general cognitive capacities to realise that the beliefs are contradictory.
Preface to Symposium on David Rondel’s Pragmatist Egalitarianism
Authors: Koopman Colin
Published: November 2019

David Rondel’s Pragmatism Egalitarianism offers valuable contributions to both contemporary pragmatist scholarship and contemporary political philosophy. The book was the focus of a discussion at the American Philosophical Association’s Pacific Division meeting in April of 2019 in Vancouver, British Columbia. That discussion forms the basis for the four essays gathered here: three critical responses from Susan Dieleman, Alexander Livingston, and Robert Talisse, as well as David Rondel’s reply to these critics. This brief prefatory essay summarizes the book and its contexts in contemporary pragmatism scholarship and political philosophy.
The Bad, The Wrong, and The Unjust: A Comment on Rondel’s Pragmatist Egalitarianism
Authors: Talisse Robert B.
Published: November 2019

In his Pragmatist Egalitarianism, David Rondel proposes a “pluralist egalitarianism” as a pragmatist resolution to longstanding debates over egalitarian justice. On Rondel’s view, egalitarianism has three distinct and irreducible variables. In this comment, I argue that pluralist views generally do not reconcile anything, but instead posit sites of normative conflict that are in principle invulnerable to remediation by human intelligence. I then propose that although Rondel might be correct to identify three distinct sites of egalitarian concern, there remains reason to prioritize what he calls the “institutional” variable.
Toward a Pragmatist Feminist Egalitarianism: Redescribing the Vertical-Horizontal Debate From a Feminist Perspective
Authors: Dieleman Susan
Published: November 2019

In this response to David Rondel’s Pragmatist Egalitarianism, I suggest that the disagreement between vertical egalitarians and horizontal egalitarians has deeper roots than Rondel acknowledges. Using feminist egalitarianism as my example, I suggest that this is because Rondel fails to note that horizontal egalitarians do not merely offer an alternative account of the sites of and remedies for inequality than do vertical egalitarians; they also see vertical egalitarianism itself as contributing to inequality. Yet I also contend that, even though the two sides of the vertical-horizontal debate are more divided than Rondel lets on, a pragmatist egalitarianism, because of its emphasis on problem-solving, is still able to circumvent this debate.
Some Political Consequences of Pragmatism
Authors: Livingston Alexander
Published: November 2019

The question of what political consequences, if any, follow from American pragmatism is nearly as old as pragmatism itself. David Rondel’s Pragmatist Egalitarianism breathes new life into this old debate. Rondel outlines a distinctively pluralistic and problem-oriented approach to political philosophy that claims to “reconcile and mediate” the false dichotomies and interminable debates marking philosophical discourses of egalitarian justice. This article identifies two competing visions of the political consequences of Rondel’s egalitarian brand of pragmatism: one Rortyan and deflationary, the other Deweyan and reconstructive. Rondel’s reconstructive argument shows how pragmatism’s democratic radicalism pushes beyond the liberal consensus of contemporary theories of justice and towards a more robust conception of democratic socialism, yet the full implications of this position are cut short by the book’s competing deflationary mode.
Pragmatist Egalitarianism Revisited: Some Replies to my Critics
Authors: Rondel David
Published: November 2019

In this article, I reply to some criticisms of my book, Pragmatist Egalitarianism, offered by professors Robert Talisse, Susan Dieleman, and Alexander Livingston. Some of the major themes and questions I address include the following: How are conflicts between different egalitarian ideals best understood and addressed? Does the quest for equality have a fundamental locus, or are the different egalitarian variables I identify in the book, conceptually speaking, on an equal footing? What is the relationship between justice and equality? How are feminist egalitarianism and Marxian egalitarianism best slotted into my distinction between “vertical” and “horizontal” egalitarianism? What does liberalism, problematic though it may sometimes be, have to contribute to the egalitarian project?
The Advancement of Altruism as a Criterion of Moral Validity
Authors: Pueyo-Ibáñez Belén
Published: November 2019

Jürgen Habermas’s discourse ethics is a method of intersubjective argumentation conceived to test the validity of moral norms on the basis of their universalizability. As some scholars have argued, Habermas’s proposal is problematic in that the process of argumentation is always affected by the circumstances of inequality and unfairness that pervade communal life and, therefore, it cannot be as inclusive and egalitarian as it needs to be in order to function effectively. In this paper, I argue that the solutions proposed by these scholars, namely, the improvement of social conditions and the pluralization of the process of argumentation, cannot by themselves resolve the practical limitation Habermas’s method presents. As an alternative, I adopt Philip Kitcher’s approach to ethics according to which the establishment of moral norms is oriented not to the resolution of disagreements but to the restitution of healthy relationships among individuals. On the basis of this alternative conception, I propose the addition to Habermas’s principle of universalization of a supplemental criterion of moral justification—one that makes the validity of norms dependent upon their potential to foster altruism.
John Dewey, Nonhuman Agency, and the Possibility of a Posthuman Public
Authors: Richards Daniel P.
Published: November 2019

This article re-visits the critiques of anthropocentricism levied against John Dewey by his contemporaries and offers a reading of this critique through the lens of nonhuman agency using the theoretical work of Bruno Latour and Jane Bennett, particularly the latter’s coverage of Dewey’s theory of democracy. This work culminates into an argument for envisioning Dewey’s publics as constituted by human and nonhuman bodies, anticipating in some ways the work of contemporary posthumanists and new materialists. This leads us to not only re-think Dewey’s typecasting as unabashedly anthropocentric but also reinvigorates the use value of Dewey’s thinking in the context of contemporary ecological issues.
Philosophical Disagreement and the Value-Laden Nature of Philosophy
Authors: Arroyo Gustavo
Published: November 2019

Disagreement in philosophy is all-pervasive and irresolvable. There is almost no thesis in philosophy about which philosophers agree. In contrast to most contemporary accounts of philosophical disagreement, I argue that a significant proportion of philosophical disagreements are rooted in differences regarding values. A second thesis that I shall defend in this paper is that disagreements regarding values are not resolvable by argumentative means.
Introduction to Special Issue: Critical Interventions on the Spaces and Practices of State Power
Authors: Chomiak Laryssa , Schwedler Jillian
Published: November 2019

Many analyses of the 2011 uprisings and their aftermath 2011 uprisings have been built explicitly on social movements theory with a focus on specific episodes of social unrest. Others have employed procedural approaches from theories of democratization. The nation-level unit of analysis dominant in these approaches reproduces classic regime-character typologies and invokes questions about the relationship between regime type and successful social mobilization. This special issue explores the spaces and practices of state power beyond the conventional framework, giving special attention to space, time, and the multiple scales of relations of power. The contributors explore how these alternative approaches open up different questions into the operation of state power—some in the specific context of the uprisings and some in the course of more quotidian administration.
Claiming Bits and Pieces of the State: Squatting and Appropriation of Public Domain in Algeria
Authors: Parks Robert P.
Published: November 2019

This article examines how Algerians negotiate property and public space and how citizens encounter and engage the state. It explores the phenomenon of squatting and appropriation of public space in contemporary Algeria through the lens of the polysemic term beylik, which can be simultaneously used to define the state, public domain, and no man’s land. It argues that, in addition to individual motivations for personal gain or out of necessity, squatting and the appropriation of public space is also a silent yet highly political act that reimagines the relationship of rights and obligations incumbent between citizen and polity. The appropriation of beylik is a process that comes from widely-held beliefs that types of unused state property are somehow unnatural, if not illegitimate, or that, as a citizen, one has the right to re-model and re-fashion it for either individual or collective use. In this sense, beylik is an empty space in which citizens re-imagine how the community should be governed. By seizing and transforming beylik, a citizen is simultaneously forgetting (or ignoring) the state, while projecting a different governing order for both private and public spheres. The silent encroachment of citizens into the domains of the state – in occupying and re-ordering state space – reveals the fluidity of Algerian institutions, inasmuch as it reveals that institutions are themselves negotiated between state and society.
When Revolutionary Coalitions Break Down: Polarization, Protest, and the Tunisian Political Crisis of August 2013
Authors: Berman Chantal
Published: November 2019

Revolutionary coalitions often break down in the aftermath of revolution, leading to the collapse of transitional governments. Fragmentation among revolutionary elites has been extensively theorized, but few works consider the origins and consequences of polarization among non-elite protesters in the revolutionary coalition. This paper examines the case of Tunisia to unpack how polarization among former revolutionaries may drive secondary waves of mobilization that imperil governing coalitions, even when elites are cooperating. Unique protest surveys of pro- and anti-government demonstrations during the Tunisian political crisis of 2013 – which catalyzed the resignation of the country’s first elected assembly – show that polarization within this coalition occurred along ideological lines concerning the role of Islam in governance but not along class lines, as some theories of transition would predict. Revolutionaries are re-mobilized in part through divergent narratives concerning which social groups participated most in the revolutionary struggle, and which groups suffered and profited most under the old regime. This paper counters the elite-centrism of predominant “transitology” approaches by highlighting how protest politics may shape institutional transitions.
Trade-Offs and Public Support for Security Reform during Democratic Transitions
Authors: J. Lotito Nicholas
Published: November 2019

During democratic transitions, newly elected governments face public demands to reform the institutions of the old regime, especially the security forces; yet, these reforms often fail. I argue that politicians define policy issues in ways that maximize popular support for their own positions through well-established processes of elite issue framing. Politicians can reduce popular demand for difficult and costly reforms of the security forces by framing them as trade-offs with other types of reform. The argument is tested with original survey data from Tunisia, an important contemporary case of democratic transition. An embedded vignette experiment primes existing issue frames by asking respondents to adjudicate between investments in security reform versus economic or political reform. I find that framing a trade-off with a more popular policy, economic development, reduces public demand for security reform. These findings have important implications for security sector reform and democratic consolidation in Tunisia and beyond.