bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term outcomes of acetabular impaction grafting with cemented cups and trabecular metal for revision hip arthroplasty: a follow-up study
Authors: Curtin Mark , Russell Shane P , Mirdad Rayyan S , Irwin Shane C , Rowan Fiachra E , Masterson Eric L , Condon Finbarr
Published: September 2024

Introduction:

Revision hip arthroplasty in the presence of complex acetabular deficiencies is challenging. Cement, allograft, reconstruction rings and porous trabecular metal now provide versatile options for acetabular fixation and restoration of acetabular offset. We compare acetabular impaction bone grafting (AIBG) and trabecular metal (TM) cups at long-term follow-up.

Methods:

53 patients who underwent revision hip arthroplasty were retrospectively reviewed from local joint registry data. 36 patients were revised using AIBG and 17 with TM. Median clinical follow-up was 9.57 (2.46–18.72) years and 9.65 (7.22–12.46) years, respectively. 82% of the TM group and 63% of the AIBG group were ⩾ Paprosky 2C. Re-revision was considered failure. Radiographs demonstrating 5 mm of femoral head migration and 5° of acetabular component inclination change were considered loose.

Results:

Patients receiving AIBG were younger (68 vs. 74 years) with a longer interval from initial arthroplasty to revision (17 vs. 13 years). Revisions in both groups were indicated most commonly for failed cementing (AIBG 88.9% vs. TM 70.5%). No TM reconstructions underwent re-revision, with only 1 failing at 6.3 years, compared with 9 AIBG re-revisions. When revising for sepsis, 33% of AIBG revisions failed.

Conclusions:

AIBG demonstrated high failure rates at long-term follow-up when compared to TM constructs. We recommend the use of AIBG in small cavitary defects only. We strongly advise against its use in the setting of significant bony defects and for prosthetic joint infection.
Downregulation of LPAR1 Promotes Invasive Behavior in Papillary Thyroid Carcinoma Cells
Authors: Bokaii Hosseini Zahra , Rajabi Fatemeh , Morovatshoar Reza , Ashrafpour Mahshad , Behboodi Panteha , Zareie Dorsa , Natami Mohammad
Published: September 2024

Background:

Lysophosphatidic acid receptor 1 (LPAR1) has been identified as a biomarker in various cancer types. However, its biological function in papillary thyroid carcinoma (PTC) remains unknown.

Methods:

LPAR1 was identified as a key regulator of epithelial-mesenchymal transition (EMT) in PTC cells through bioinformatics analysis of TCGA and GEO datasets. PPI analysis and correlation with immune infiltrates were also conducted. LPAR1 expression was evaluated using Gepia2 and GTEx, and miRNA target gene prediction was done with multiMiR. To assess the expression of LPAR1, we extracted total RNA from both the BCPAP cell line and the normal human thyroid epithelial cell line Nthy-ori 3-1. The levels of LPAR1 expression were then measured using quantitative real-time polymerase chain reaction (qRT-PCR) in the BCPAP cell line, with a comparison to the Nthy-ori 3-1 cell line.

Results:

1081 genes were upregulated, and 544 were downregulated compared to normal tissue. LPAR1 was identified as a key candidate by analyzing the TCGA and GEO datasets. PPI data analysis showed interactions with metastasis-related proteins. Functional enrichment analysis indicated involvement in signaling pathways like phospholipase D and actin cytoskeleton regulation. LPAR1 expression correlated positively with immune infiltrates such as CD4+ T cells, macrophages, neutrophils, and myeloid dendritic cells but negatively with B cells. Additionally, miR-221-5p was predicted to target LPAR1 in PTC. Furthermore, our experimental data demonstrated that LPAR1 was under-expressed in the PTC cell line compared to the nonmalignant one ( P < .01).

Conclusion:

LPAR1 suppresses metastasis and is linked to EMT, as evidenced by the decreased LPAR1 expression and increased miR-221-5p in PTC. This suggests its potential as a biomarker for diagnosis and prognosis and as a therapeutic target for EMT.
Exposure to Smoking as a Predictor of ADHD Subtypes Among Children Within Saudi Arabia: An Observational Study
Authors: Zakariyah Abeer , Al Qutub Sulafa , Kazim Sereen , Alharbi Reman , Alharthi Hams , Alharbi Hadeel , Albassami Maram , Hanbazazh Mehenaz , Mahnashi Morooj
Published: September 2024

Previous studies have found an association between maternal smoking and an increased risk of attention deficit hyperactivity disorder (ADHD) in offspring. However, the prevalence of maternal smoking, secondhand smoke (SHS) exposure during pregnancy, and ADHD in children within the Saudi Arabian context is not well-documented. Objective: To explore the prevalence of maternal smoking and SHS exposure during pregnancy among mothers of children diagnosed with ADHD and investigate exposure to smoking as a predictor of ADHD subtypes. Methods: A cross-sectional study was conducted from December 1, 2022, to February 28, 2023, using an online questionnaire. The study included 217 parents of children aged 4-17 years diagnosed with ADHD and without a family history of the disorder. Data on sociodemographic determinants, academic achievement, ADHD types, and maternal smoking habits during pregnancy were collected. Results: Among the mothers surveyed, 6.4% reported smoking during pregnancy, while 41% were exposed to SHS. The study found a predominance of the combined subtype of ADHD among the children. Logistic regression analysis revealed that families with monthly income <10 000 SR were 2.6 times more likely to have a child with inattentive or hyperactive ADHD ( P < 0.03). Male gender was associated with a 46% reduced likelihood of these subtypes ( P < 0.03). SHS smoking and active exposure to smoking during pregnancy did not show any significant effect on ADHD. Conclusion: The study found that child gender and family income were significantly associated with the distribution of ADHD subtypes, while maternal smoking and SHS exposure during pregnancy did not show a significant association. The high prevalence of SHS exposure emphasizes the need for increased public health awareness and interventions to promote smoke-free environments during pregnancy.
Serum Potassium in Thyroid Cancer Patients With Hypothyroidism During Thyroid Hormone Withdrawal: A Retrospective Study
Authors: Tangsermvong Poonyisa , Chamroonrat Wichana , Vittayachokkitikhun Siripong , Sriphrapradang Chutintorn
Published: September 2024

Background:

Several case reports and a few studies have reported that hypothyroid patients have elevated serum potassium levels. However, hypothyroidism has not been widely accepted as a cause of hyperkalemia.

Objectives:

This study aims to evaluate the incidence of hyperkalemia and factors influencing serum potassium levels in thyroid cancer patients with hypothyroidism during thyroid hormone withdrawal before radioactive iodine (RAI) treatment.

Methods:

We conducted a retrospective review of electronic medical records from January 2017 to June 2021, involving 956 thyroid cancer patients post-thyroidectomy and undergoing RAI. Laboratory parameters, including serum potassium levels, were collected in both euthyroid (<1 year prior to RAI) and hypothyroid states.

Results:

Among 508 patients (mean age 52 years, 79.3% female), hyperkalemia (potassium ⩾ 5.0 mEq/L) occurred in 2.8%, without severe hyperkalemia (potassium ⩾ 6.5 mEq/L). The hypothyroid state exhibited significantly higher serum potassium than the euthyroid state [4.16 (IQR, 3.94-4.41) vs 4.10 (IQR, 3.90-4.35) mEq/L, P < .01]. The mean change in potassium levels between the euthyroid and hypothyroid state was 0.05 ± 0.17 mEq/L. Pre-thyroid hormone withdrawal (euthyroid state) factors associated with serum potassium levels in the hypothyroid state included age, use of angiotensin-converting enzyme inhibitors, diabetes mellitus, serum BUN/creatinine, serum potassium levels, hemoglobin A1c (positive correlation); and thiazide use and eGFR (negative correlation). In the hypothyroid state, hyperkalemia was more likely in patients with serum potassium ⩾4.2 mEq/L (OR 9.36, P < .01) or free T4 ⩾1.38 ng/dL (OR 7.05, P < .01) during the euthyroid state.

Conclusions:

The incidence of hyperkalemia was low in our hypothyroid cohorts. However, physicians should remain vigilant for cases with risk factors for developing hyperkalemia.
Comparison of Infection Rate Between Sterile and Nonsterile Gloves During Mohs Micrographic Surgery: An Updated Systematic Review and Meta-Analysis
Authors: Sarto Rubiana , Pereira Lívia F. , Mesquita Yasmin , Chater Regina C. , Lapenda Izadora , Moury Luana , Moraes-Souza Rafaela
Published: September 2024

Background:

Mohs micrographic surgery (MMS) is a well-established technique for the removal of various types of skin cancers. While sterile gloves (SG) are commonly used in skin surgeries such as MMS, additional understanding of their effectiveness compared to nonsterile gloves (NSG) in preventing local infection is required.

Objective:

We aimed to perform an updated systematic review and meta-analysis comparing the use of SG with NSG for local infection rate post-MMS and point out cost discrepancies between these 2 scenarios.

Methods:

We searched MEDLINE, Embase, and Cochrane for studies published up to August 2023 comparing the use of SG with NSG during MMS that reported the outcome of wound infection.

Results:

A total of 4 studies with 10,644 MMS were included, of which 7512 (70.6%) were performed with SG and 3132 (29.4%) were done with NSG. In the SG group, 232 out of 7512 cases (3.1%) developed infection compared to 64 out of 3132 (2.0%) in the NSG group [odds ratio (OR) 1.14; 95% confidence interval (CI) 0.85-1.52; P = .39; I2 = 0%]. Therefore, the post-MMS infection rates were not significantly different between SG and NSG groups, including in the excision (OR 0.92; 95% CI 0.48-1.79; P = .81; I2 = 0%) and reconstruction (OR 1.17; 95% CI 0.85-1.60; P = .34; I2 = 0%) subanalysis. Regarding the mean cost of the gloves, the NSG pair was $0.24, approximately 10% of the price of the SG pair ($2.27).

Conclusion:

The results support that, compared to SG, NSG are equally effective in preventing infections during MMS while offering significant cost savings without compromising patient outcomes. Protocol registration: PROSPERO, CRD42023458525
The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis
Authors: Sarthou Aurélie , Chrétien Pascale , Giorgi Laetitia , Chiron Andrada , Leroy Carole , Horellou Philippe , Krzysiek Roman , Deiva Kumaran , Hacein-Bey-Abina Salima
Published: September 2024

Background:

Multiple sclerosis (MS) may occur before the age of 18. Differentiation between paediatric MS (PedMS) and other demyelinating syndromes (ODSs) is challenging. In adult with MS, the kappa free light chain (KFLC) index has proven to be a reliable marker of intrathecal Ig synthesis.

Objective:

To assess the diagnostic value of the KFLC index in a cohort of patients with paediatric-onset, inflammatory disorders of the CNS.

Methods:

We included 73 patients and divided them into four groups: PedMS ( n = 16), ODS ( n = 17), encephalitis and/or inflammatory epilepsy (EE, n = 15), and controls without inflammatory CNS diseases ( n = 25). The KFLC index was calculated and compared with the results of the oligoclonal bands determination.

Results:

The KFLC index was higher in the PedMS group (median (interquartile range (IQR)): 150.9 (41.02–310.6)) than in the ODS (3.37 (2.22–8.11)), the EE (5.53 (2.31–25.81)) and the control group (3.41 (2.27–5.08)), respectively. The best KFLC index cut-off for differentiating between patients with PedMS and controls was 6.83 (sensitivity: 100%; specificity: 92%). A KFLC index over 93.77 indicated that the patient is very likely to have PedMS (sensitivity: 68%; specificity: 100%).

Conclusion:

The KFLC index is a reliable tool for the diagnosis of MS in a paediatric population.
Gender differences in the labour market insertion of tourism graduates
Authors: Escalonilla Marta , Boto-García David
Published: September 2024

This article studies gender differences in labour mobility, employment type, contract type, and sectoral mismatch among tourism graduates in the first 4 years after graduation. We exploit a longitudinal dataset of seven graduation cohorts to ascertain gender differences in their labour market insertion process at the beginning of their careers. We estimate Heckman probit regressions for each outcome variable that deal with self-selection into employment status. Our results show that females are less likely to move outside their region for labour reasons and more likely to work part-time and with temporal contracts. Moreover, females exhibit a 15 per cent higher probability of being horizontally mismatched in their jobs. Importantly, the documented gap remains over time and even widens, suggesting a faster transition of males towards matched jobs and better labour conditions.
A multigroup SEM analysis of mediating role of enjoyment, anxiety, and boredom in the relationships between L2 motivational self-system, L2 proficiency, and intercultural communication competence
Authors: Tang Lingjie , Zhang Chang’an , Cui Yu
Published: September 2024

This study aims to test a mediation model to understand how the second language motivational self-system (L2MSS) affects second language (L2) proficiency and intercultural communication competence (ICC) through the mediating effects of foreign language enjoyment, anxiety, and boredom among English as a foreign language (EFL) learners in China. A total of 2,713 Chinese EFL learners, comprising 1,376 English majors and 1,337 non-English majors, voluntarily participated in the present study. Structural equation modeling (SEM) analysis was conducted to analyse the collected data. Additionally, a multigroup SEM approach was applied to compare potential differences between the two major types in the hypothesized relationships. The results revealed that the impacts of the ideal self and learning experience positively and directly predicted L2 proficiency and ICC, whereas the ought-to self had a direct and negative influence. Foreign language enjoyment, anxiety, and boredom mediated the relationships between L2MSS, L2 proficiency, and ICC. Also, L2 proficiency positively affected ICC. Moreover, the multigroup SEM analysis revealed that these two groups did not differ significantly in the hypothesized pathways, suggesting that these relationships were not moderated by students’ majors. These research findings may present significant implications for EFL learners and teachers.
Seasonal indoor air quality, self-reported health and comfort amongst tenants living at Danish multi-family social housing sites
Authors: Gabel Charlotte , Elholm Grethe , Petersen Steffen , Sigsgaard Torben
Published: September 2024

Studies have identified seasonal differences between the indoor environment and residents’ comfort, as well as an association between indoor air quality (IAQ) and residents’ overall health. Furthermore, measured IAQ is not always aligned with perceived IAQ. The HOME-Health study is a cross-sectional study with seasonal measurements of IAQ amongst residents living in social housing. The aim is to describe and analyse measured and perceived IAQ, and residents’ health symptoms. We found a lower relative humidity, temperature (TP) and air change level (h−1) level, and a higher carbon dioxide (CO2) level during winter compared to summer. In general, higher IAQ levels were measured in apartments with increased crowdedness. The inability to be able to create cross ventilation increased TP, and a larger number of rooms decreased TP. Overall, there was no clear alignment between measured and perceived IAQ, but we found a trend that higher CO2-levels led to a perception of poor IAQ especially during summer. Overall, draught and thermal discomfort were the most common complaints. Self-reported humidity was increased during winter and was associated with nasal and respiratory symptoms, whereas self-reported humidity during summer was associated with fatigue and dermal symptoms. Findings show challenges with IAQ in Danish social housing that are associated with negative health issues.
Systematic review of subjective validation methods for computerized colonoscopy simulators
Authors: Lugilde-López Adrián , Caeiro-Rodríguez Manuel , Mikic-Fonte Fernando A. , Llamas-Nistal Martín
Published: September 2024

Introduction: In recent years, different approaches have been used to conduct a subjective assessment of colonoscopy simulators. The purpose of this paper is to review these different approaches, specifically the ones used for computerized simulators, as the first step for the design of a standard validation procedure for this type of simulators. Methods: A systematic review was conducted by searching papers after 2010 in PubMed, Google Scholar, ScienceDirect, and IEEE Xplore databases. Papers were screened and reviewed for procedures regarding the subjective validation of computerized simulators for traditional colonoscopy with an endoscope. Results: An initial search in the databases identified 2094 papers, of which 7 remained after exhaustive review and application of exclusion criteria. All studies used questionnaires for subjective validation, with “face” being the most common validity type tested, while “content” validity and “usability” were less prominent. Conclusions: A classification of subscales for testing face validity was derived from the studies. The Colonoscopy Simulator Realism Questionnaire (CSRQ) was selected as the guide to follow for the development of future questionnaires related to subjective validation. Mislabeling of the validity tested in the studies due to ambiguous interpretations of the validity types was a common occurrence observed in the reviewed studies.
A multivariate and wavelet-based analysis on the wall pressure fluctuations for propellers in ground effect
Authors: Kamliya Jawahar Hasan , Hanson Liam , Meloni Stefano , Azarpeyvand Mahdi
Published: September 2024

This study, conducted at the University of Bristol’s aeroacoustic facility, explores the aeroacoustic characteristics of a 10-inch APC propeller in pusher configuration within ground effect conditions. Tested at a rotational speed of 7000 r/min, the propeller’s performance was evaluated at varying distances from the ground. Wall pressure fluctuations near the propeller were measured at eight radial points, complemented by far-field acoustic measurements. Consistent with previous research, distinctive thrust and torque behaviours were observed when operating both in and out of ground effect. Notably, a significant noise increase of approximately 5 dB was observed on the ground’s reflected side, while a reduction of about 14 dB was detected on the shielded side. Higher-order statistical analysis such as skewness and kurtosis revealed substantial effects of tip vortex impingement in ground effect conditions. This study applies two-point statistics and the Corcos model to analyze propeller-induced wall pressure fluctuations. The coherence function effectively captures the intricate dynamics of pressure variations across different spatial locations and frequencies. This approach offers novel insights into the behaviour of boundary layers and flow-induced pressures in the context of propellers operating in the ground effect. Wavelet decomposition was utilized to differentiate the influences of the boundary layer and the acoustic field. This comprehensive analysis highlights the intricate dynamics of propeller operation in ground effect, contributing valuable insights to the field of aeroacoustic research.
Nonlinear ultrasonic Lamb wave phased array imaging based on hybrid array and time-reversal of harmonic
Authors: Li Xuan , Liu Lishuai , Xu Haiming , Xiang Yanxun , Xuan Fu-Zhen
Published: September 2024

Fatigue cracks, as one of the early performance deteriorations of plate-like structures, are critical to be detected in a timely manner to prevent further failures and disastrous accidents. But the intimate contact of crack interfaces is difficult to form a significant scattering field of traditional ultrasonic Lamb waves, resulting in the insensitivity of Lamb wave phased array-based imaging methods to crack imaging. To break through the detecting limitations of conventional Lamb wave phased array, the nonlinear Lamb wave-based phased array method is first proposed to realize fatigue crack imaging, which is achieved by a new form of phased array with hybrid elements, signal processing for harmonic enhancement and time-reversal based harmonic field focusing. The hybrid array is designed for efficient transmission and capture of fundamental wave and harmonics, and Pulse-inversion technology and continuous wavelet transform filter are used to extract and enhance second harmonic response, and the images are obtained by the time domain topological energy imaging algorithm. Finally, the imaging results of barely visible fatigue cracks and through-holes in metallic plate structures using linear and nonlinear Lamb wave-phased array are compared. The nonlinear ultrasonic Lamb wave-phased array demonstrates excellent capability of fatigue crack imaging.
Investigating the evolution of road surface descriptors according to observation angles using a database of the reflection properties of urban materials
Authors: Saint-Jacques E , Brémond R , Eymond F , Morvan K
Published: September 2024

For road lighting design, road surface descriptors like the degree of lightness Q0 and specular factor S1 are derived from reflection properties (or Bidirectional Reflectance Distribution Function (BRDF)) of road surfaces. However, these BRDF are based on outdated road surface characteristics and are also partial (they are called r-tables) because only the motorist’s 1° observation angle is considered. Thus, the need to have full BRDF measurements of current road surfaces available. This paper proposes to use a recently released open source database of measured whole BRDF by means of our in-lab gonioreflectometer to investigate the performance of Q0 and S1 according to observation angles. We first compare descriptors obtained from measured and interpolated r-tables and find a good accuracy, especially for Q0. Then we propose a model for these descriptors function of the observation angle, and find quite an accurate fitting. Finally, we suggest a methodology for the classification of road surfaces which equally considers Q0, S1 and the observation angles, and propose a tentative classification of road surfaces based, not in terms of their materials, but rather in terms of their usage-driven performance.
Evaluating the impact of road lighting on pedestrian reassurance through the day-dark approach
Authors: Wei L , Bizjak G , Kobav MB
Published: September 2024

A field study in the urban area of Ljubljana, Slovenia, explored the impact of variations in lighting parameters on pedestrian perceptions of safety, visual comfort and risk. Utilising the day-dark approach with 35 participants, this research evaluates differences in perception under daytime and after dark (but with road lighting) environments to determine the optimal lighting conditions. The results suggested that a minimum horizontal illuminance of 1.8 lx, corresponding to a day-dark differential of 0.5 on a 5-point scale, and a minimum luminance of about 0.15 cd m−2 were optimal for perceived safety and comfort. The results suggest that minimum illuminance provided a more effective predictor of pedestrian reassurance than did the other lighting parameters considered.
Comparative study: High performance polymers of polyphenylene sulfide and polyethylenimine using Taguchi-Topsis optimization approaches
Authors: Öktem Hasan , Konada Naresh Kumar , Karasungur Halit
Published: September 2024

The role of high-performance thermoplastic products is increasing in the present days because of its excellent physical and mechanical properties and also capable of withstanding critical loads and temperatures. In this study, an attempt was made to improve the mechanical and physical properties of two polymers PPS (Polyphenylene Sulfide) and PEI (Polyethylenimine) by addition of glass fiber as a reinforcement fiber. The glass fiber (GF) content considered as 40 wt% for both the polymers. Injection molding method was used for fabrication of PPS and PEI samples. After fabrication, mechanical tests such as tensile, impact and dimensional shrinkage (%) of samples were calculated. Taguchi and Topsis analysis techniques were applied for evaluation of major influencing parameters and determining the best experiment to be performed on the machine. After conducting the test, PPS polymer exhibited better mechanical strength values and lower shrinkage (%) compared to PEI. The best input parameters kept on the machine were observed to be gate way type, temperature and pressure. The conditions of gate way type 2, temperature 320°C, and a pressure of 100 bar are obtained as the best input parameters to be fixed on the machine for achieving higher values of mechanical strength and lower dimensional shrinkage for both PPS and PEI polymers. Out of these two polymers, PPS exhibited better mechanical and physical properties combining with GF. This polymer can extend its usage as a high-performance polymer for various industrial applications.
Critical analysis of the subspecialty stroke medicine curriculum: Social and political influences on its design and professionalism
Authors: Gul Samia , Shahid Muhammad
Published: September 2024

The curriculum comprises all learners’ learning experiences that enable them to achieve specific learning outcomes. The Subspeciality Stroke Medicine Curriculum is designed to train doctors in Stroke Medicine as specialists capable of providing holistic healthcare in preventing, treating and rehabilitating stroke through achieving the desired competencies. This article discusses the influence of factors like the development of learning theory, the democratisation of social process, public demand for accountability and transparency, political imperatives, economic factors and professional standards set by professional bodies on curriculum design. The curriculum focuses on an outcome-based educational approach, workplace-based assessment with formative feedback to promote learning, summative evidence for knowledge, skills and attitudes and greater integration to make learning closer to actual practice. This outcome-based, integrated approach is approved by regulating bodies as positively impacting doctors’ training and, consequently, the health of individual patients and society.
Five Forms of Coerced “Self-Produced” Child Sexual Exploitation Material: A Critical Interpretive Synthesis
Authors: Bloxsom Genevieve , McKibbin Gemma , Humphreys Cathy , Davidson Jennifer , Halfpenny Nick
Published: September 2024

This review explored how the phenomenon of coerced “self-produced” child sexual exploitation material (CSEM) has been constructed in the literature using Critical Interpretative Synthesis. Selected keywords were systematically searched on relevant databases. Types of papers included were: peer-reviewed research articles; conceptual papers; commentary papers; theses; book chapters; systematic reviews; and government reports. Papers published in English between January 2005 and November 2022 were included. The initial search revealed 1,021 papers, after two reviewers applied the inclusion and exclusion criteria, 38 papers were selected for the final sample. Findings indicated five forms of coerced “self-produced” CSEM: Solicitation; Peer Sexting; Viral Challenge; Sextortion; and Financial Coercion. The forms are described and critically analyzed through an “Accountability Lens.” This Lens was developed to be victim-centered including identifying the coercive actions of the person responsible for the exploitation. The review found an absence of a consistent victim-centered approach to how the phenomena of coerced “self-produced” CSEM is understood that would ensure children are not held responsible for being exploited.
Bias-Based Cyberaggression Related To Origin, Religion, Sexual Orientation, Gender, and Weight: Systematic Review of Young People’s Experiences, Risk and Protective Factors, and the Consequences
Authors: Jaron Bedrosova Marie , Dufkova Eliska , Machackova Hana , Huang Yi , Blaya Catherine
Published: September 2024

Bias-based cyberaggression—hateful and bias-based content and interactions via information and communication technologies—is a frequent experience for young internet users that can result in detrimental consequences for both individuals and society. Ample research has focused on the factors related to involvement in bias-based cyberaggression. This study systematically reviews the research published in the past decade about the investigations into exposure, vicarious and direct victimization, and aggression among young people (up to age 30). We aimed to provide a complex summarization of the research findings about the risk and protective factors and the consequences of experiences with bias-based cyberaggression—specifically the diverse manifestations of bias-based cyberaggression targeted toward ethnicity, race, nationality, religion, sexual orientation, gender, weight, and disability. Three academic databases (EBSCO, Scopus, and WoS) were searched and 41 articles were included in the review. The results show a dominant research focus on bias-based cyberaggression victimization and on the bias-based cyberaggression that targets ethnicity, race, nationality, and religion, leaving a gap in the knowledge about the different types of targeted group categories and bias-based cyberaggression perpetration. The identified risk factors for bias-based cyberaggression involvement included being a minority, low psychological well-being, other victimization experiences, higher internet use, and risky internet use. An overlap was found for bias-based cyberaggression involvement with other offline and online victimization experiences. This review showed limited knowledge about protective factors, namely the social-level and contextual factors. The identified factors, as well as the gaps in the knowledge, are discussed in relation to research implications and practice and policy implications.
Piloting a Virtual Yoga and Mindfulness Program for Juvenile Court Involved Youth
Authors: Cruce Amanda , Slade Ebonie , Savage Friedman Felicia , Savage Maya , Miller Elizabeth , Szoko Nicholas
Published: September 2024

Juvenile court-involved youth (JCIY) face unique psychosocial challenges, with a higher prevalence of mental health concerns and substance use disorders. The COVID-19 pandemic intensified these challenges, prompting a need for interventions that address trauma and discrimination experienced by this vulnerable population that could be delivered virtually during the pandemic. This study describes implementation and evaluation of a Raja yoga and mindfulness program among JCIY, with particular attention to barriers and facilitators to participation to inform next steps in this work. The nine-session program aimed to promote mindfulness practices, build coping skills, and address elements of JCIY’s emotional health and well-being. Despite challenges in participant retention, participants expressed intent to use skills they learned in the future. Challenges related to implementation included technological barriers, staff turnover, and competing responsibilities; abrupt closure of the county juvenile detention center further strained resources. Successes included providing real-time resources during the early pandemic stages and building relationships between program facilitators and juvenile court staff. Involving youth and court personnel in program design and evaluation, adopting implementation science approaches to refine program delivery, and developing tailored support systems for JCIY are among the key lessons learned. Given the many structural inequities that make JCIY more vulnerable to poor health outcomes, insights may inform broader efforts to improve receipt of relevant services and programs to enhance their well-being, including use of virtual modalities.
Introduction to the special issue: The Platformization of Cancel Culture
Authors: Farries Elizabeth , Kerrigan Páraic , Siapera Eugenia
Published: September 2024

Cancel culture claims, narratives and practices now play out in predominantly platformed spaces, spanning from progressive publics and accountability practices to reactionary/anti-woke/far right publics. We argue that platform affordances, architectures and cultures serve as a nodal point to bring together a disparate set of practices, discourses and ideological positions to facilitate polarized, reactionary, and or strategic networked publics in the context of digital politics and the (re)emergence of culture wars. Papers within this special issue speak to our argument in varying ways. They explore the mechanisms, sentiments, tolerances, and practices in local and global contexts. They consider how certain practices manifesting as social justice interventions apply to negatively impact marginalized groups, theorize the role of and power of platforms in propelling cancelations, and track the rituals associated with cancel culture on platforms. In doing so we encompass perspectives and case studies from the global majority to inform what has to date been a largely Western area of focus and scholarship.
cnevent: Event study with Chinese equity market data
Authors: Li Chuntao , Fang Yizhuo , Cao Lifang
Published: September 2024

In this article, we present a new command, cnevent, that runs event studies about Chinese-listed companies. With cnevent, researchers are required to provide only a list of events with the Chinese stock code and the corresponding date for each event, and the command can automatically extract indexes and each individual stock’s return data to run the whole process of the event study. Furthermore, cnevent enables users to choose the benchmark from among different market indexes and different event window sets with options. The command then generates daily abnormal returns for all trading days within the event window and aggregates the cumulative abnormal returns (CARs) for the whole event window. Finally, cnevent can plot a graph to show the trend of the CARt within the event window and test whether the event has a significant effect on valuation.
miesize: Effect-size calculation in imputed data
Authors: Tiffin Paul A.
Published: September 2024

In this article, I describe the miesize command for the calculation of effect sizes in imputed data. There may be situations where an effect size needs to be estimated for an intervention, an exposure, or a group membership variable but data on the independent or dependent variable are missing. Such missing data are commonly dealt with by multiply imputing plausible values. However, in this circumstance, the estimated effect size and associated standard errors will need to be pooled and estimated from the imputed dataset. The miesize command automates this process and calculates effect sizes for a binary variable from multiply imputed data in wide format. The estimates and standard errors (used to calculate the confidence intervals) are recombined using Rubin’s (1987, Multiple Imputation for Nonresponse in Surveys [Wiley]) rules. These rules are applied such that the average point estimate for the effect size is calculated from the imputed datasets. The pooled standard error, and hence confidence intervals, is calculated to account for both the variance between the imputed datasets and the variance within them. Pooled effect sizes and confidence intervals for Cohen’s (1988, Statistical Power Analysis for the Behavioral Sciences, 2nd ed. [Lawrence Erlbaum]) d, Hedges’s (1981, Journal of Educational Statistics 6: 107-128) g, and Glass’s ( Smith and Glass, 1977 , American Psychologist 32: 752-760) delta are provided by miesize.
Endovascular Treatment of Aortoiliac Aneurysms With the Bell-Bottom Technique: A Systematic Review and Meta-Analysis
Authors: Volteas Panagiotis , Giannopoulos Stefanos , Koudounas Georgios , Asencio Anthony , Chandrashekar Anirudh , Karkos Christos , Virvilis Dimitrios
Published: September 2024

Objective

Aneurysmal degeneration of the common iliac artery (CIA) can pose a challenge to achieve distal landing zone sealing at the time of endovascular abdominal aortic aneurysm repair (EVAR). The aim of this study was to summarize the current literature regarding the bell-bottom technique (BBT) for ectatic CIAs during EVAR.

Methods

This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible articles were identified through a comprehensive search of PubMed, Scopus, and Cochrane Central published until April 2023. A meta-analysis was conducted using the random effects model and the I2 statistic was used to assess for heterogeneity. The primary endpoints were type Ib/III endoleak, graft occlusion/limb embolization, and reintervention rate. Secondary endpoints included perioperative adverse events and mortality.

Results

Overall, twenty-six studies and 4332 patients with flared limbs were included. The pooled estimate for type Ib/III endoleak was 4% (95% CI: 2-6, I2 = 85.6%), for reintervention rate was 9% (95% CI: 6-12, I2 = 90.4%), and for overall mortality was 10% (95% CI: 4-19, I2 = 97.3%). No aneurysm related deaths were recorded. Comparative analysis showed similar type Ib/III endoleak, graft occlusion, and reintervention rates between the EVAR BBT, iliac branch endoprosthesis (IBE), and embolization of the internal iliac artery followed by extension of the iliac limb to the external iliac artery (EIE) groups.

Conclusions

The use of flared limbs could be considered a reasonable first line choice for EVAR cases with CIA ectasia as it is simpler, allows for future IBE or EIE and does not increase the risk for type Ib/III endoleak or graft occlusion. Further comparative studies with longer follow-up are needed.
Open Surgical Repair in a Patient With Loeys-Dietz Syndrome and Extensive Vascular Compromise: A Case Report and Literature Review
Authors: Polania-Sandoval Camilo A. , Farres Houssam , Lanka Santh Prakash , Erben Young
Published: September 2024

Loeys-Dietz syndrome (LDS) has been associated with multiple vascular abnormalities involving the entire arterial tree. However, limited reports regarding compromise in the aortoiliac and femoral bifurcation are available. Further, recommendations for optimal approach, thresholds for diameter at the time of surgery, and surveillance are also limited. We present a case of a 67-year-old male patient with LDS and aneurysmal aortoiliac and enlarging common femoral arteries aneurysms, who underwent open surgical repair. His past surgical history included multiple vascular interventions for lower extremity claudication and bilateral hip replacements. The right hip arthroplasty was previously removed due to infection. From the vascular standpoint, the patient underwent staged endovascular left hypogastric artery embolization and open aorto-bi-profunda bypass with a Rifampin-soaked Dacron graft. At 5-month follow-up, he remains asymptomatic with healed incisions and patent bypasses. This case highlights the challenges in managing peripheral aneurysms in LDS patients, emphasizing the need for tailored treatment strategies. While open repair is preferred, endovascular options may be considered in selected cases. Surveillance remains critical with annual cross-sectional imaging. Surgical planning is intricate due to comorbidities, anatomical complexities, and previous surgical infection. Surveillance of these patients must be strict as multiple vascular and non-vascular complications may arise. Therefore, collaborative decision-making is essential for optimal outcomes in this known high-risk population with connective tissue disorders.
In Defense of Imagination: Canadian Youth Culture and the Dungeons & Dragons Panic in Canada, 1980–1995
Authors: Gagné Alex
Published: September 2024

Dungeons & Dragons (D&D), the iconic tabletop role-playing game released in 1974, sparked controversy from its early inception. This article examines the emergence of moral panic around D&D, particularly in the United States and Canada during the early 1980s. It explores how concerned groups, such as Bothered Against Dungeons & Dragons, portrayed the game as a corrupting influence on American youth. Focusing on the spread of panic into Canada, this article investigates the role of American media in shaping Canadian perceptions. This study highlights questions about transnational cultural influence and the impact of media on societal norms. Was the moral panic primarily a result of American cultural influence, or was there tangible evidence linking D&D to real-world violence in Canada? Through analysis of media representation and cultural discourse, this article seeks to shed light on these complex dynamics and to highlight moments of youth resistance to narratives of moral panic.
Examining Real-World Evidence of Depression-Related Symptom Reduction Through a Comprehensive Holistic Lifestyle Intervention
Authors: Sutliffe Jay T. , Lopez Nanette V. , Papini Natalie M. , Herrmann Stephen D.
Published: September 2024

Depression is a global health concern, with various treatments available. In this study, participants (n = 430) were self-selected or medically referred to a residential lifestyle program at the Black Hills Health & Education Center (BHHEC), with a mean stay of 19 days. Individualized treatment plans included structured physical activity sessions, counseling sessions, and the provision of a vegan diet. Beck Depression Inventory-II, self-reported total exercise minutes, resistance exercise minutes, and sleep, along with the number of holistic treatments and counseling sessions, were evaluated. Paired samples t-tests indicated a significant decrease in depression scores over time (MT1 = 20.14, MT2 = 6.17, P < .001). Results from the multiple linear regression that evaluated total exercise minutes, resistance exercise, number of treatments and counseling sessions, and average reported hours of nightly sleep on depression scores at time 2 indicated that average reported hours of nightly sleep were the only significant predictor of depression scores at time 2 ( P < .05). While depression scores significantly improved from baseline to post-assessment for all participants, it is possible that an unmeasured variable, or the synergistic intervention effect of the wellness program, accounted for changes in depressive symptoms over time. Future studies should incorporate sleep quality and assessing time spent in nature to explore these relationships further.
Perfusion deficit and vessel wall characteristics to predict recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion
Authors: Zhou Chun , Cao Yue-Zhou , Jia Zhen-Yu , Zhao Lin-Bo , Lu Shan-Shan , Xu Xiao-Quan , Shi Hai-Bin , Liu Sheng
Published: September 2024

Background

To investigate the association between perfusion deficit, vessel wall characteristics, and risk of recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion.

Methods

We retrospectively reviewed chronic symptomatic patients due to anterior circulation large vessel occlusion in our center. All patients received multiparametric magnetic resonance imaging (including perfusion-weighted imaging and high-resolution vessel wall imaging) within 4 weeks to 3 months after symptom onset. The association between baseline clinical or imaging variables and recurrent ischemic events was assessed in bivariate models and multivariable logistic regression to identify independent predictors of recurrence.

Results

Among 71 enrolled patients, 21.1% (15/71) patients had recurrent ischemic events (nine ischemic strokes and six transient ischemic attacks) during a 2-year follow-up. In bivariate models, hypertension, occlusion with hyperintense signals, the presence of intraluminal thrombus, Tmax >4 s volume, Tmax >6 s volume, Tmax >8 s volume, and Tmax >10 s volume were associated with recurrence (all p < 0.05). In multivariate analysis, hypertension ( p = 0.039, OR 10.057 (95% CI, 1.123–90.048)), higher deficit volume of Tmax >4 s ( p = 0.011, OR 1.012 (95% CI, 1.003–1.021)) and occlusion with hyperintense signal ( p = 0.030, OR 6.732 (95% CI, 1.200–37.772)) were still independent predictors of recurrent ischemic events.

Conclusions

Besides hypertension history, higher deficit volume of Tmax >4 s and occlusion with hyperintense signal determined using multiparametric MRI are strongly associated with risk for recurrent ischemic events in medically treated patients with chronic symptomatic anterior circulation large vessel occlusion. Future studies are needed to determine the utility of revascularization strategies in such high-risk patients.
A prospective, randomized, controlled, interventional clinical trial to evaluate the safety and efficacy of the medical monopoint reperfusion system for aspiration thrombectomy in acute ischemic stroke patients (SUMMIT MAX): Trial rationale and design
Authors: Dabus Guilherme , Puri Ajit S , McGuinness Ben , Priest Ryan A , Rai Ansaar T , Gross Bradley A , Zaidat Osama O , Hanel Ricardo A , Shazam Hussain M , Shaikh Hamza A , English Joey D , Nguyen Thanh N
Published: September 2024

Background

Treatment of large vessel occlusion (LVO) using mechanical thrombectomy with or without intravenous thrombolysis has demonstrated better outcomes compared to medical treatment alone. Large-bore aspiration catheters have been recently introduced. Their effectiveness and safety have not been demonstrated in a randomized trial. The SUMMIT MAX study is designed to address this question.

Methods

SUMMIT MAX is a randomized controlled trial where the effectiveness and safety of the large-bore Monopoint Reperfusion system (Route 92 Medical, San Mateo, CA), will be compared to the currently largest available FDA-cleared aspiration thrombectomy device the AXS Vecta Aspiration system (Stryker Neurovascular, Fremont, CA). The study is a multi-center, prospective, randomized, controlled, interventional, open label clinical trial. The hypothesis is that the effectiveness measured by the recanalization rate (modified thrombolysis in cerebrovascular infarction - mTICI) and safety measured by symptomatic intracranial hemorrhage rate (sICH) of the medical monopoint reperfusion system is non-inferior to the AXS Vecta Aspiration system.

Results

Up to 250 subjects are enrolled with at least 50% of subjects enrolled by US sites. The primary effectiveness endpoint is successful arterial revascularization defined as an mTICI score ≥ 2b after use of the assigned device adjudicated by an independent core lab. The primary safety endpoint is defined as sICH within 24 h (−8/+24) post-procedure. Secondary endpoints include successful arterial revascularization defined as a mTICI score ≥ 2b after use of the assigned device with or without adjunctive therapy; device-related serious adverse events; all asymptomatic hemorrhages; time from groin puncture to final angiogram; and rate of first pass effect defined as mTICI 2b after first pass with the assigned device stratified by age (≤85, ≥ 86).

Conclusion

SUMMIT MAX is a randomized controlled trial comparing the effectiveness and safety of a new large bore class of aspiration devices to the currently largest FDA-cleared aspiration device available.