bluuebunny/crossref_metadata_2025 huggingface dataset:
Gait Transition from Pacing by a Quadrupedal Simulated Model and Robot with Phase Modulation by Vestibular Feedback
Authors: Fukui Takahiro , Matsukawa Souichiro , Habu Yasushi , Fukuoka Yasuhiro
Published: December 2021

We propose a method to achieve autonomous gait transition according to speed for a quadruped robot pacing at medium speeds. We verified its effectiveness through experiments with the simulation model and the robot we developed. In our proposed method, a central pattern generator (CPG) is applied to each leg. Each leg is controlled by a PD controller based on output from the CPG. The four CPGs are coupled, and a hard-wired CPG network generates a pace pattern by default. In addition, we feed the body tilt back to the CPGs in order to adapt to the body oscillation that changes according to the speed. As a result, our model and robot achieve stable changes in speed while autonomously generating a walk at low speeds and a rotary gallop at high speeds, despite the fact that the walk and rotary gallop are not preprogramed. The body tilt angle feedback is the only factor involved in the autonomous generation of gaits, so it can be easily used for various quadruped robots. Therefore, it is expected that the proposed method will be an effective control method for quadruped robots.
Predictive Analytic Techniques to Identify Hidden Relationships between Training Load, Fatigue and Muscle Strains in Young Soccer Players
Authors: Mandorino Mauro , Figueiredo António J. , Cima Gianluca , Tessitore Antonio
Published: December 2021

This study aimed to analyze different predictive analytic techniques to forecast the risk of muscle strain injuries (MSI) in youth soccer based on training load data. Twenty-two young soccer players (age: 13.5 ± 0.3 years) were recruited, and an injury surveillance system was applied to record all MSI during the season. Anthropometric data, predicted age at peak height velocity, and skeletal age were collected. The session-RPE method was daily employed to quantify internal training/match load, and monotony, strain, and cumulative load over the weeks were calculated. A countermovement jump (CMJ) test was submitted before and after each training/match to quantify players’ neuromuscular fatigue. All these data were used to predict the risk of MSI through different data mining models: Logistic Regression (LR), Random Forest (RF), Support Vector Machine (SVM). Among them, SVM showed the best predictive ability (area under the curve = 0.84 ± 0.05). Then, Decision tree (DT) algorithm was employed to understand the interactions identified by the SVM model. The rules extracted by DT revealed how the risk of injury could change according to players’ maturity status, neuromuscular fatigue, anthropometric factors, higher workloads, and low recovery status. This approach allowed to identify MSI and the underlying risk factors.
An Equifinality Energy Management Framework in Terms of Benchmarking Practices and Expectations: The EnerMan Project Outlook
Authors: Katrakazas Panagiotis , Costantino Marco , Magnea Federico , Moore Liam , Ismail Abdelgafar , Bourithis Eleftherios , Taşkın Hasan Basri , Özen Zeynep Tutku , Sarı İlyas Artunç , Pissaridi Katerina , Bachler Johann , Polic Stefan , Pippione Giulia , Paoletti Roberto , Falco Rosa di , Ferrario Fabio
Published: December 2021

Background: The Industry 4.0 wave is leading the changes in existing manufacturing and industrial processes across the world. This is especially important in the formulation of the smart-factory concept with an outlook to energy sustainable processes. In viewing and identifying the foundational elements of such a transformation, the initial conditions and current practices in a cross-sectoral manner is considered a first, yet crucial step in the EU-funded project EnerMan. Methods: In this paper, we identify and analyse the key common features and characteristics of industrial practices set in a perspective of similar and identical functions with a focus to three key energy areas: sustainability, management, and footprint. The examination of different industrial sector cases is performed via distributed questionnaires and then viewed under the prism of the equifinality state via a text-mining analysis approach. Results: identification of common themes and benchmarking of current practices in a cross-industry manner led to the creation of a common systemic framework within energy management related aspects, which is hereby presented. Conclusions: use of an equifinality approach in energy management practices should be further pursued to open up new methods of ideation and innovation and communicate systems’ design in tandem with each industrial set goals.
Lethal and Sub-Lethal Effects and Modulation of Gene Expression Induced by T Kinase Inhibitors in Zebrafish (Danio Rerio) Embryos
Authors: Elersek Tina , Novak Matjaž , Mlinar Mateja , Virant Igor , Bahor Nika , Leben Karin , Žegura Bojana , Filipič Metka
Published: December 2021

Tyrosine kinase inhibitors (TKIs) are designed for targeted cancer therapy. The consumption of these drugs during the last 20 years has been constantly rising. In the zebrafish (Danio rerio) embryo toxicity test, we assessed the toxicity of six TKIs: imatinib mesylate, erlotinib, nilotinib, dasatinib, sorafenib and regorafenib. Imatinib mesylate and dasatinib induced lethal effects, while regorafenib, sorfenib and dasatinib caused a significant increase of sub-lethal effects, predominantly oedema, no blood circulation and formation of blood aggregates. The analyses of the changes in the expression of selected genes associated with the hormone system after the exposure to imatinib mesylate, dasatinib and regorafenib demonstrated that all three tested TKIs deregulated the expression of oestrogen receptor esr1, cytochrome P450 aromatase (cypa19b) and hydroxysteroid-dehydrogenase (hsd3b), regorafenib, and also thyroglobulin (tg). The expression of genes involved in the DNA damage response (gadd45 and mcm6) and apoptosis (bcl2) was deregulated only by exposure to regorafenib. The data indicate that common mechanisms, namely antiangiogenic activity and interference with steroidogenesis are involved in the TKI induced sub-lethal effects and potential hormone disrupting activity, respectively. The residues of TKIs may represent an environmental hazard; therefore, further ecotoxicological studies focusing also on the effects of their mixtures are warranted.
Tomography of the Ie-Re and L-Sigma Planes
Authors: D’Onofrio Mauro , Chiosi Cesare
Published: December 2021

We have analyzed the distribution of early-type galaxies (ETGs) in the effective surface intensity vs. effective radius (Ie−Re) plane and in the total luminosity vs. central stellar velocity dispersion (L−σ) diagram, with the aim of studying the physical variables that allow the transformation of one space-parameter into the other. We find that the classical Faber–Jackson relation L=L0σα, in which the parameters L0 and α are confined in a small range of possible values, is incompatible with the distribution observed in the Ie−Re plane. The two distributions become mutually consistent only if luminosity is not considered a pure proxy of mass but a variable tightly dependent on the past history of mass assembling and star formation and on the present evolutionary state of the stellar content of a galaxy. The solution comes by considering the L=L0′σβ law proposed by D’Onofrio et al. in 2020, in which both L0′ and β can vary considerably from galaxy to galaxy. We will also show that the data of the Illustris numerical simulation prove the physical foundation of the L=L0′σβ law and confirm the prediction of the Zone of Exclusion (ZoE) originating from the intersection of the virial law with the L=L0′σβ relation. The ZoE is the region in the Ie−Re and Re−Ms diagrams avoided by real galaxies, and the border of which marks the condition of ‘full’ virial equilibrium with no recent significant merger events and no undergoing star formation.
The Role of Risk Perception in Students’ COVID-19 Vaccine Uptake: A Longitudinal Study
Authors: Hilverda Femke , Vollmann Manja
Published: December 2021

Since COVID-19 vaccine uptake was found to be especially low among young adults, the present study investigated COVID-19 risk perception as predictor of COVID-19 vaccination intention and actual COVID-19 vaccine uptake among this age group. More specifically, it was tested whether cognitive risk perception predicts vaccination uptake successively via affective risk perception and vaccination intention. In total, 680 students (65.9% female) between 17 and 28 years participated in this longitudinal online study. COVID-19 cognitive and affective risk perception, COVID-19 vaccination intention, and actual COVID-19 vaccine uptake were measured in t1: November/December 2020, t2: March 2021, and t3: June/July 2021, respectively. The mediation analysis revealed a significant indirect effect of perceived severity at t1 on vaccine uptake at t3 via worry at t1 and vaccination intention at t2. Stronger perceptions of perceived severity of COVID-19 were related to more worry about COVID-19, which led to a higher vaccination intention, which, in turn, increased the chance of COVID-19 vaccine uptake. To increase vaccine uptake among young adults it might be fruitful to emphasize the severity of COVID-19. However, one should take into account that tapping into fear works best when messages also include efficacy statements.
MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation
Authors: Li Yang , Yang Shanshan , Huang Xin , Yang Ning , Wang Caiying , Zhao Jing , Jing Zhizhong , Willems Luc , Liu Guangliang
Published: December 2021

Intestinal microfold (M) cells are critical for sampling antigens in the gut and initiating the intestinal mucosal immune response. In this study, we found that the oral administration of dextran sulfate sodium (DSS) and Salmonella infection induced colitis. In the process, the expression levels of M cell differentiation-related genes were synchronized with the kinetics of pro-inflammatory cytokines. Compared to wild-type (WT) mice, MyD88−/− mice exhibited significantly lower expression levels of M cell differentiation-related genes. However, DSS induced colitis in MyD88−/− mice but failed to promote the transcription of M cell differentiation related genes. Furthermore, the receptor activator of the Nuclear Factor-κB ligand (RANKL) upregulated the transcription of M cell differentiation related genes in murine intestinal organoids prepared from both WT and MyD88−/− mice. Meanwhile, fewer changes in M cell differentiation related genes were found in MyD88−/− mice as compared to WT mice. Hence, we concluded that myeloid differentiation factor 88 (MyD88) is an essential molecule for colitis- and RANKL-related differentiation of M cells.
Forecasting Reservoir Water Levels Using Deep Neural Networks: A Case Study of Angat Dam in the Philippines
Authors: Ibañez Sebastian C. , Dajac Carlo Vincienzo G. , Liponhay Marissa P. , Legara Erika Fille T. , Esteban Jon Michael H. , Monterola Christopher P.
Published: December 2021

Forecasting reservoir water levels is essential in water supply management, impacting both operations and intervention strategies. This paper examines the short-term and long-term forecasting performance of several statistical and machine learning-based methods for predicting the water levels of the Angat Dam in the Philippines. A total of six forecasting methods are compared: naïve/persistence; seasonal mean; autoregressive integrated moving average (ARIMA); gradient boosting machines (GBM); and two deep neural networks (DNN) using a long short-term memory-based (LSTM) encoder-decoder architecture: a univariate model (DNN-U) and a multivariate model (DNN-M). Daily historical water levels from 2001 to 2021 are used in predicting future water levels. In addition, we include meteorological data (rainfall and the Oceanic Niño Index) and irrigation data as exogenous variables. To evaluate the forecast accuracy of our methods, we use a time series cross-validation approach to establish a more robust estimate of the error statistics. Our results show that our DNN-U model has the best accuracy in the 1-day-ahead scenario with a mean absolute error (MAE) and root mean square error (RMSE) of 0.2 m. In the 30-day-, 90-day-, and 180-day-ahead scenarios, the DNN-M shows the best performance with MAE (RMSE) scores of 2.9 (3.3), 5.1 (6.0), and 6.7 (8.1) meters, respectively. Additionally, we demonstrate that further improvements in performance are possible by scanning over all possible combinations of the exogenous variables and only using a subset of them as features. In summary, we provide a comprehensive framework for evaluating water level forecasting by defining a baseline accuracy, analyzing performance across multiple prediction horizons, using time series cross-validation to assess accuracy and uncertainty, and examining the effects of exogenous variables on forecasting performance. In the process, our work addresses several notable gaps in the methodologies of previous works.
A Study of Drag Reduction on Cylinders with Different V-Groove Depths on the Surface
Authors: Qi Jiyang , Qi Yue , Chen Qunyan , Yan Fei
Published: December 2021

In this study, the drag reduction effect is studied for a cylinder with different V-groove depths on its surface using a k-ω/SST (Shear Stress Transport) turbulence model of computational fluid dynamics (CFD), while a particle image velocimetry (PIV) system is employed to analyze the wake characteristics for a smooth cylinder and a cylinder with different V-groove depths on its surface at different Reynolds numbers. The study focuses on the characteristics of the different V-groove depths on lift coefficient, drag coefficient, the velocity distribution of flow field, pressure coefficient, vortex shedding, and vortex structure. In comparison with a smooth cylinder, the lift coefficient and drag coefficient can be reduced for a cylinder with different V-groove depths on its surface, and the maximum reduction rates of lift coefficient and drag coefficient are about 34.4% and 16%, respectively. Otherwise, the vortex structure presents a complete symmetry for the smooth cylinder, however, the symmetry of the vortex structure becomes insignificant for the V-shaped groove structure with different depths. This is also an important reason for the drag reduction effect of a cylinder with a V-groove surface.
Temperature Impact on Reverse Osmosis Permeate Flux in the Remediation of Hexavalent Chromium
Authors: Shigidi Ihab , Anqi Ali E. , Elkhaleefa Abubakar , Mohamed Azam , Ali Ismat H. , Brima Eid I.
Published: December 2021

Reverse osmosis technique was applied in removing hexavalent chromium ions from artificial wastewater. Different operating conditions were studied to monitor the separation process using commercial Reverse Osmosis BW30XFR membrane. Different concentrations of hexavalent chromium; 5, 30, and 100 ppm were tested. Samples were subjected to incrementally increasing operating pressure; 10, 30, and 45 bar and flow rates; 2.2, 3.4, and 4.5 L/min under various temperatures; 25, 35, 45, and 55 °C. Collected permeate and concentrations were measured after each experiment using a UV spectrophotometer. Results obtained presented a higher rejection percentage at lower feed concentrations with a value up to 99.8% for 5 ppm in comparison to 94.3% for 30 ppm and 77.2% for 100 ppm concentration due to concentration polarization; however, it showed no effect of increasing operating flow rates. Moreover, the increase in feed temperature from 25 to 55 °C had positively increased permeate flux to more than 300 times. The permeate flux at 25 °C is recorded for all tested samples in the range of 30 to 158 kg/h·m2, this range has risen at 55 °C under the same conditions to the range of 70 to 226 kg/h·m2, indicating alteration within the membrane pore size due to temperature increase and high applied pressure concluding high sensitivity of polymeric membranes towards changing permeate flow rate with increasing temperatures.
Optimization of TSPWM for Common-Mode Voltage Reduction in Vehicular Electric Drive System
Authors: Jiang Shang , Wang Yuan
Published: December 2021

Common-mode voltage can be reduced effectively by optimized modulation methods without increasing additional costs. However, the existing methods cannot satisfy the requirements of the vehicular electric-drive application. This paper optimizes the tri-state voltage modulation method to reduce the common-mode voltage for vehicular electric drive system applications. Firstly, the discontinuous switching issue during sector transition is analyzed. Under the limit of two switching times in one period, multiple alignments combination is proposed to address that issue. Secondly, the zero-voltage time intervals in different modulation ranges are explored. This paper proposes an unsymmetric translation method to reconstruct the voltage vector, and then the minimum zero-voltage time interval is controlled to enough value for safe switching. Finally, the proposed methods have been validated through experiments on a vehicular electric drive system. The results show that the common-mode voltage can be reduced effectively in the whole range with the optimized tri-state voltage modulation method.
Helmintosis y eventos alérgicos
Authors: Fonte Galindo Luis , Méndez Sutil Yuliet , Sarracent Pérez Jorge , Baldriche Acosta Jessica , Fabré Ortiz Dania
Published: December 2021

En las últimas tres décadas se ha reconocido un alarmante aumento en la frecuencia de las en- fermedades  alérgicas,  asociadas  con  cuadros  de  parasitismos,  y  este  número  sigue  creciendo. Se realizó una revisión del tema, en cuanto a características clínicas, epidemiológicas y factores inmunológicos que identifican a esta asociación. El objetivo de esta revisión es exponer, algunos aspectos relevantes de estas patologías. Se destaca la importancia del papel modulador de las hel- mintiasis, en el desarrollo de las alergias; sin embargo, las evidencias de esta asociación no están claramente establecidas, por lo que existe todavía en la comunidad científica, la controversia y el debate, acerca de este tema y específicamente de los mecanismos que intervienen en la modula- ción de las alergias por los parásitos helmintos.

Palabras clave: Geohelmintosis, helmintiasis, alergia.

Abstract:

In the last three decades an alarming increase in the frequency of allergic diseases associated with symptoms of parasitism has been recognized, and this number continues to grow. A review of the topic was conducted regarding clinical, epidemiological and immunological factors that identify this association. The objective of this review is to present some important aspects of these pathologies. The importance of modulatory helminthiasis, in the development of allergies is highlighted; however, the evidence of this association is not clearly established, so there is still, in the scientific community, controversy and debate about this issue and specifically of the mechanisms involved in the modula- tion of allergies by helminth parasites.

Key words: Geohelmintosis, helminth infections, allergies.
Oximetría de pulso en el pesquisaje de malformaciones congénitas cardiovasculares en recién nacidos
Authors: Burgos Quiroga Ana Gabriela , Caicedo Freire María Lissette , Toledo Santana Nancy , Marín Pérez Alfredo , Marín Toledo Ilien , Ramírez Fernández Juan Antonio
Published: December 2021

Las malformaciones congénitas cardiovasculares son anomalías del desarrollo estructural del corazón que ocurren en el período embrionario y son una de las principales causas de morbimortalidad infantil. Sus manifestaciones clínicas suelen ser tardías por los cambios circulatorios que existen durante el paso a la vida extrauterina. La oximetría de pulso es un método de detección precoz de cardiopatías congénitas, considerada una herramienta capaz de detectar grados de hipoxemia leve que la exploración clínica no revela. Con el objetivo de determinar la utilidad de la oximetría de pulso en el pesquisaje de cardiopatías congénitas, prueba empleada por primera vez en el Hospital Verdi Cevallos, se realizó un estudio exploratorio, prospectivo, cuantitativo en 203 recién nacidos a término sanos, entre las 24 a 48 horas de vida. Los datos sociodemográficos y clínicos se obtuvieron de las historias clínicas maternas y neonatales. De los neonatos que resultaron positivos a la prueba, algunos no presentaron soplos a la auscultación, siendo la única manifestación clínica, la baja saturación de oxígeno. La confirmación del diagnóstico se realizó mediante la ecocardiografía revelando cardiopatías simples como la comunicación interauricular e interventricular; severas como la comunicación interventricular asociada a estenosis pulmonar y, críticas como la transposición de grandes vasos.

Palabras clave: oximetría de pulso, pesquisa, cardiopatías congénitas.
Péptidos bioactivos presentes en la leche: revisión
Authors: Collado Luis , García Tatiana , Ciudad María , Garicano Vilar Elena , San Mauro Ismael
Published: December 2021

Los péptidos bioactivos son un conjunto de moléculas de naturaleza proteica presentes en la leche de forma natural, con potenciales efectos beneficiosos en el organismo humano. El objetivo es realizar una revisión actualizada de la literatura científica sobre la acción de estos compuestos en el organismo. Se realizó una revisión bibliográfica con la base de datos MEDLINE como fuente de información. Selección de artículos científicos de las últimas 2 décadas y, de entre ellos, los artículos más relevantes sobre los diferentes compuestos y sus múltiples acciones biológicas. Se ha encontrado multitud de publicaciones recientes que registran las acciones biológicas de estos compuestos en el ser humano y muestran sus capacidades de protección de la salud y prevención de diversas patologías.

Palabras clave: leche, proteína, péptido, bioactivo.
Asociaciones entre alimentos, flora intestinal y sistema nervioso central
Authors: Caballero Torres Angel Eladio , Fernández Vélez Yumy Estela
Published: December 2021

Existe un incremento del interés sobre posibles efectos de la alimentación en el funcionamiento del sistema nervioso central, aunque la importancia de esa influencia parece requerir mayores respaldos científicos. Estos señalamientos son motivos para   valorar, sobre la base de los aportes de otros autores, el posible significado de la relación de alimentos, flora intestinal y sistema nervioso. Para cumplir este objetivo fue necesario una búsqueda de informaciones científicas en la US National Library of Medicine sobre este tema, una selección de publicaciones relevantes y análisis de los datos encontrados. Según esas publicaciones, la protección de la inocuidad de los alimentos, probióticos y algunas sustancias químicas de la dieta tienen relación con la composición y funcionamiento de la flora intestinal que puede afectar el eje intestino cerebro y causar alteraciones en el funcionamiento del sistema nervioso central. Se acepta que son insuficientes las explicaciones sobre relaciones específicas entre componentes de la dieta y efectos en el sistema nervioso central de los consumidores de alimentos, incluyendo los posibles mecanismos de esas relaciones.

 

Palabras clave: alimentos, eje intestino cerebro, sistema nervioso central, microbiota intestinal.

 

Abstract

 

There is an increased interest in possible effects of food on the central nervous system functioning, although the importance of this influence seems to require more scientific support. These indications are reasons to value, based on the contributions of other authors, the possible meaning of the relationship of food with the intestinal flora and the nervous system. To accomplish this goal, a search of scientific information was necessary for the US National Library of Medicine on this topic, a selection of relevant publications and analysis of the data found. According to those publications, food safety, probiotics and some dietary chemicals has a relationship with to the composition and functioning of the intestinal microbiome that can affect the brain intestinal axis and cause alterations in the functioning of the central nervous system. It’s accepted that explanations about specific relationships between diet components and effects on the central nervous system of food consumers, including the possible mechanisms of these relationships, are insufficient.

 

Key words: food, intestine brain axis, central nervous system, nutrition, intestinal microbiota.
Infecciones fúngicas cutáneas profundas: Revisión de la literatura
Authors: Olivera Cardozo Maria , Pérez Ortiz Viorkis , Piñón Gámez Aimee , Mejia Montilla Jorly , Reyna Eduardo Javier
Published: December 2021

Las infecciones fúngicas cutáneas profundas son cada vez más comunes debido tanto a la inmunosupresión como a la dispersión global. Comprender estas infecciones, requiere no solo leer muchos informes de casos y verificar las imágenes clínicas típicas de las lesiones cutáneas, sino también manejar adecuadamente a los pacientes para evitar diagnósticos erróneos. Esta revisión se realizó en PubMed, MEDLINE, EMBASE, con las palabras clave: Infecciones fúngicas cutáneas profundas, micosis, dermatomicosis, diagnóstico e histopatología micótica. El total de artículos consultados fueron 151 y se seleccionaron 81 para esta revisión. Se encontró la descripción de las micosis cutáneas profundas realizadas por varios autores y se resumen los hallazgos histopatológicos de estas infecciones fúngicas que se observan comúnmente en la práctica clínica diaria. El reconocimiento precoz de este tipo de infecciones es importante, ya que estas patologías se asocian frecuentemente con una alta morbilidad, en especial en sujetos con alteraciones de la inmunidad.

 

Palabras clave: Infecciones fúngicas, profundo cutáneo, micosis, histopatología, diagnóstico.

 

Abstract

 

Deep cutaneous fungal infections are becoming more common due to both immunosuppression and global dispersion. Understanding these fungal infections requires not only reading many case reports and verifying typical clinical images of skin lesions but also properly managing patients to avoid misdiagnosis. This systematic review was made on PubMed, MEDLINE, EMBASE, with the key words: Deep cutaneous fungal infections, mycosis, dermatomycosis, diagnosis and mycotic histopathology. The total number of the articles consulted for it, was 151 and 81 articles were selected for this review. On those, the deep cutaneous mycoses were described for some authors and the histopathological findings of those fungal infections that are commonly observed in daily clinical practice are summarized. Early recognition of this type of infection is important since these pathologies are frequently associated with high morbidity, especially in subjects with impaired immunity.

 

Keywords: Fungal infections, deep cutaneous, mycosis, histopathology, diagnosis.
Detección de cáncer oculto de mama metastásico con compromiso ocular. Presentación de un caso clínico
Authors: Marrero González Dadier , López Díaz Lizeet , Aldama Rodríguez María Isabel
Published: December 2021

El cáncer de mama es la neoplasia más frecuente en el sexo femenino y la segunda causa de muerte por cáncer en la mujer, puede hacer metástasis en pulmón, hígado, hueso, cerebro y órbita, representando esta última menos del 1 % de los casos reportados. Con el objetivo de describir un caso clínico atípico, se reporta una paciente de 56 años, que debuta con cefalea frontal y adenopatías cervicales unilaterales. La biopsia de adenopatía cervical informó: metástasis de un carcinoma poco diferenciado de origen mamario con receptores hormonales de estrógeno y progesterona positivos por Inmunohistoquímica (IHQ). Con estudios de extensión negativos y sin presencia de lesión mamaria-axilar, se interpreta como un cáncer oculto de mama metastásico con compromiso ocular. Actualmente en seguimiento controlado de su enfermedad, aunque mantiene cefalea y pérdida de visión, pero sin enfermedad visceral ni primaria demostrable. Con este trabajo se pretende demostrar la importancia del diagnóstico diferencial y oportuno de los tumores metastásicos intraorbitarios.

 

Palabras clave: Neoplasias de la mama, cáncer orbitario, metástasis.

 

Abstract

 

Breast cancer is the most frequent malignancy in females and the second cause of cancer death in women can metastasize to lung, liver, bone, brain, and orbit, representing the latter less than 1% of reported cases. With the aim of describing an atypical clinical case, a 56 years old female patient was reported, who debuted with a frontal headache and unilateral cervical adenopathies. The cervical adenopathy biopsy reported: metastasis of a poorly differentiated carcinoma of mammary origin; with hormone receptors of estrogen and progesterone positive by Immunohistochemistry (IHC). With negative extension studies and no presence of the mammary-axillary lesion, it is interpreted as a hidden cancer of the metastatic breast in orbit. Currently in the controlled monitoring of his disease, although he maintains a headache and loss of vision but no visceral disease or primary provable. This work aims to demonstrate the importance of differential and timely diagnosis of intraorbital metastatic tumors.

 

Key words: neoplasma mammary cancer, orbital cancer, metastasis.
Consecuencias clínicas del Zika en recién nacidos del Hospital Regional Verdi Cevallos Balda, año 2016
Authors: Pico Franco Monserratt Betzabhé , García Quijije Jose Alberto , Giler Bardellini David , Meza Valdez Luisa Lisbeth , Loor Cevallos Ginger Andrea , Vinces Carrillo Gema Maricela , Zamora Cevallos Shirley Magdalena
Published: December 2021

El zika es una enfermedad causada por un flavivirus que se transmite por la picadura del mosquito Aedes infectado con el virus. Su infección afecta especialmente a las embarazadas, dando lugar a alteraciones en el feto como microcefalia congénita y el síndrome de Guillain-Barré. En este trabajo se determinaron las consecuencias clínicas del virus en recién nacidos del Hospital Verdi Cevallos Balda. En este sentido, se realizó un estudio retrospectivo, descriptivo y cuantitativo en 62 mujeres gestantes infectadas por el virus, de los 62 recién nacidos uno murió por complicaciones (encefalocele y microcefalia). Los factores sociodemográficos arrojaron que la mayoría de las embarazadas infectadas tenían entre los 20 y 25 años; así como que el lugar de residencia de la mayoría durante la gestación fueron las parroquias Andrés de Vera y Francisco Pacheco, sitios donde las condiciones socioeconómicas permiten una menor prevención de la enfermedad y una mayor proliferación del vector. El 59,68 % de las gestantes se infectaron durante el segundo trimestre, y más de la mitad (64,52 %) de los neonatos presentaron síndrome de zika congénito sin complicaciones.

 

Palabras clave: Microcefalia, complicaciones, gestación.

 

Abstract

Zika is a disease caused by a flavivirus that is transmitted by the bite of the Aedes mosquito infected with the virus. Its infection especially affects pregnant women, leading to alterations in the fetus such as congenital microcephaly and Guillain-Barré syndrome. In this work, the clinical consequences of the virus were determined in newborns at the Verdi Cevallos Balda Hospital. In this sense, a retrospective, descriptive and quantitative study was carried out in 62 pregnant women infected by the virus, of the 62 newborns, one died of complications (encephalocele and microcephaly). Sociodemographic factors showed that most of the infected pregnant women were between 20 and 25 years old; as well as that the place of residence of the majority during pregnancy was the parishes Andrés de Vera and Francisco Pacheco, places where socioeconomic conditions allow less prevention of the disease and greater proliferation of the vector. 59.68% of the pregnant women were infected during the second trimester, and more than half (64.52%) of the newborns had congenital Zika syndrome without complications.

 

Keywords: Microcephaly, complications, pregnancy.
Consideraciones breves sobre microbiota intestinal en la prevención y tratamiento de la covid-19
Authors: Caballero Barrios Jenny , Caballero Torres Angel Eladio , Fernández Vélez Yumy Estela
Published: December 2021

La microbiota intestinal de los miembros de la especie humana tiene un papel determinante en el estado de salud por sus contribuciones a la defensa del hospedero; mientras las alteraciones de su composición y funcionamiento pueden influir en el desarrollo de enfermedades. Por estas razones, el objetivo de este trabajo fue identificar, en publicaciones científicas, posibles asociaciones de la microbiota intestinal y respuestas del hospedero a la exposición al SARS-CoV-2. Se realizó una búsqueda y análisis de artículos científicos publicados desde enero del 2017 hasta septiembre del 2020 con explicaciones sobre microbiota intestinal que pudieran vincularse con respuestas a la exposición al SARS-CoV-2 y patogenia de la covid 19. Se encontraron informaciones relevantes sobre la vinculación de la microbiota intestinal con el envejecimiento, enfermedades cardiovasculares y pulmones. Se observaron señalamientos útiles para el tratamiento y prevención de covid 19 por lo cual es posible afirmar que la microbiota intestinal puede influir en las respuestas del hospedero a infecciones de SARS-CoV-2. No obstante, se requiere mayor dominio sobre este tema para contribuir a la superación y prevención de esta enfermedad.

Palabras clave: Microbiota intestinal, covid 19, SARS-CoV-2.
Electroforesis de proteínas séricas asociadas a disproteinemias en pacientes ecuatorianos
Authors: Vélez Arteaga Diego Armando , Sosa Fernández-Aballí Lilian , Zambrano Mera Jorge , Howland Álvarez Ivón
Published: December 2021

En este trabajo se caracterizaron los resultados patológicos de las electroforesis de proteínas (ELP) de pacientes atendidos en el Hospital Dr. Julio Villacreses Colmont (SOLCA-Manabí) entre 2015 y 2018. Se realizó un estudio retrospectivo, longitudinal y descriptivo de las características analíticas, clínicas y demográficas de los pacientes con resultados de ELP patológicas obtenidas en equipo Minicap (Sebia). La población estuvo conformada por 992 ELP y la muestra quedó constituida por 629 que resultaron patológicas (89 %). Se encontró que en el periodo evaluado se solicitaron ELP a menos del 1 % del total de pacientes atendidos a pesar de las facilidades diagnósticas que ofrece la prueba. En el estudio predominaron las mujeres y la edad media fue de 63 años, con mayor frecuencia de presentación entre la cuarta y octava décadas de vida. La mayoría de las electroforesis patológicas fueron gammapatías policlonales (GP), seguidas por gammapatías monoclonales (GM) lideradas por el mieloma múltiple. Se observaron componentes monoclonales débiles y componentes oligoclonales no relacionados a diagnóstico de GM. Se concluyó que un examen de proteínas totales no sería suficiente para poder diferenciar entre GM y GP; sin embargo, en caso de no disponer de un resultado inmediato de ELP, lo cual sería óptimo, una hiperproteinemia con hipoalbuminemia y una relación del coeficiente albúmina/globulinas disminuido, orientarían hacia el diagnóstico precoz del tipo de gammapatía.

Palabras clave: Electroforesis capilar, electroforesis de proteínas, gammapatía, hipoproteinemia.
Moringa oleifera Lam. (Moringaceae): evaluación nutricional y clínica en modelos animales y correspondencia con investigaciones en humanos
Authors: Vásquez Giler Yira A. , Carrillo Farnés Olimpia V. , Vidal Novoa Alexis , Marrero González Dadier
Published: December 2021

Moringa oleifera es una especie vegetal que pertenece a la familia Moringaceae. Durante cientos de años, poblaciones de diferentes países han considerado que posee propiedades medicinales y nutritivas. Recientemente se le ha prestado atención en países tropicales y subtropicales de Europa del Este, América Latina, el Caribe y Asia, y se ha ganado un lugar en la industria de suplementos, ingredientes funcionales y en la fortificación de alimentos. El objetivo de este trabajo fue relacionar los hallazgos bioquímicos y fisiológicos determinados en modelos experimentales animales y los que se han logrado demostrar en humanos en los mismos aspectos, mediante el empleo de M. oleifera; con un llamado de atención a aquellas similitudes y diferencias entre el modelo animal y el prototipo humano. Los efectos beneficiosos de M. oleifera vinculados al tratamiento de la diabetes mellitus, dislipidemias y anemia se han asociado en gran medida al contenido y variedad de sustancias antioxidantes que posee y que complementan su valor en nutrientes. Esta revisión enfatiza en la necesidad de desarrollar experimentos controlados en humanos para estudiar el papel de los principios activos de M. oleifera en nutrición y clínica para establecer las formas idóneas de suministrar la planta y dosis óptimas que permitan lograr los efectos deseados, de manera que resulte aceptable al paladar y sea una solución sostenible en el tratamiento de estas enfermedades.

Palabras clave: Moringa oleífera, modelos experimentales, antioxidantes, diabetes mellitus, dislipidemias, anemia.
Intervención educativa de enfermería en la adherencia terapéutica de adultos mayores con diagnósticos de hipertensión y diabetes durante la pandemia COVID-19
Authors: Cajamarca Karen Michelle , Jiménez Ana Lucía
Published: December 2021

Las bajas cifras de adherencia terapéutica se han convertido en un problema de salud a nivel mundial, por lo que la presente investigación tuvo como objetivo aplicar una intervención educativa de enfermería sobre la adherencia terapéutica a adultos mayores con diagnósticos de hipertensión y diabetes durante la pandemia COVID-19, mediante un estudio de tipo cuantitativo-explicativo, con diseño cuasi experimental y de corte transversal. La muestra estuvo constituida por 30 adultos mayores pertenecientes al Club de Leones del barrio Sigsicalle Sur, divididos en un grupo experimental y otro de control, con 15 personas cada uno. En lo referente a los resultados, el grupo experimental presentó porcentajes de adherencia pre y post intervención de 65,3 y 76,15 %, respectivamente. Mientras que el grupo de control disminuyó la adherencia en 1,48 %. En cuanto a la primera dimensión acerca de la ingesta de medicación, alimentos y ejercicio, aumentó la adherencia en 12,77 %, respecto a la dimensión relacionada con el seguimiento médico-conductual acrecentó en 7,14 % y sobre la tercera dimensión de autoeficacia, incrementó 12,64 %. En conclusión, se muestra la efectividad de la intervención sobre la adherencia terapéutica, por lo que se puede afirmar el aporte significativo del rol educativo de enfermería durante la pandemia COVID-19.

Palabras clave: Intervención; educación; enfermera; pandemia.
Ebeveynlerin canlandırma sırasında çocuklarının yanında bulunmaya ilişkin görüşleri: Yoğun bakım ünitesi örneği-
Authors: YT Bahar , AYSEL Kokcu , KUĞUOĞLU Sema
Published: December 2021

Giriş ve Amaç: Bu çalışma, ebeveynlerin canlandırma sırasında çocuklarının yanında bulunmaya ilişkin görüşlerini belirlemek amacıyla, tanımlayıcı ve metodolojik olarak yapılmıştır.

Klinik çalışmalarda etkinliği kanıtlanmış olmasına rağmen, daratumumabın gerçek yaşam verilerinden elde edilen literatür bilgileri ülkemizde oldukça sınırlıdır. Bu nedenle merkezimizde daratumumab ile tedavi edilen hastaların karakteristik özelliklerini ve yanıt oranlarını incelemeyi amaçladık.

Gereç ve Yöntemler: Araştırmanın evrenini, İstanbul'daki özel bir üniversite hastanesinin bebek ve çocuk yoğun bakım ünitelerinde bebek ve çocukları yatan ebeveynler, örneklemini ise Haziran 2018-Şubat 2019 tarihleri arasında araştırmaya katılmaya gönüllü olan 222 ebeveyn oluşturmuştur. Veriler, araştırmacılar tarafından “Tanıtıcı Bilgi Formu” ve “Canlandırma Sırasında Ebeveyn Görüşlerine İlişkin Veli Görüş Formu” (cronbach alpha: .85) ile toplanmıştır. Çalışmada elde edilen veriler lisanslı SPSS (Statistical Package for Social Sciences) Windows 22.0 programı kullanılarak analiz edilmiştir.

Bulgular: Araştırma kapsamında; ebeveynlerin canlandırma odasında bulunmak istedikleri (%64.0), daha önce yaşamını kaybeden bir yakınının canlandırma işlemine tanıklık etmedikleri (%88.3), sağlık çalışanlarının konuya ilişkin eğitim almasını düşündükleri (%89.2), canlandırma odasında bulunmalarının çocuklarına yapılması gereken tüm uygulamaların yapıldığına inanmalarını sağlayacağı (%76,6), canlandırma işleminden sonra çocuklarıyla vedalaşmak için uygun bir ortam bekledikleri (%78,4), ailelerin canlandırma odasında bulundukları takdirde sağlık çalışanları tarafından desteklenmeyi bekledikleri (%84,2), sağlık kurumlarında ailelere yönelik canlandırma prosedürleri geliştirilmesini istedikleri (%85,6) saptanmıştır.

Sonuç: Bulgular, sağlık kurumlarında çocukların canlandırma odasında ebeveynlerinin bulunmasına yönelik kapsamlı protokol ve prosedürlerin geliştirilerek standardize edilmesi, gerektiğini göstermektedir.
Bel Ağrısı Olan Hastalarda Huzursuz Bacak Sendromunun Risk Faktörleri ve Denge Üzerine Etkisi: Karşılaştırmalı Bir Çalışma
Authors: CAN AKMAN Tuba , TEKİN Fatih
Published: December 2021

Giriş ve amaç: Bu çalışmanın amacı, kronik bel ağrısı olan hastalarda Huzursuz Bacak Sendromu’nun (HBS) risk faktörlerini ve denge üzerine etkisini incelemektir.

Gereç ve yöntem: Pamukkale Üniversitesi Hastanelerine daha önce bel ağrısı şikayetiyle başvurmuş, dahil edilme kriterlerine uyan 98 olgu dâhil edilmiştir. Bu olgulardan HBS olan (HBS+) 66 olgu çalışma grubuna, HBS olmayan (HBS-) 32 olgu ise kontrol grubuna alınmıştır. Tüm olguların demografik bilgileri alınmış ve Uluslararası HBS Çalışma Grubu HBS Şiddet Skalası’na göre değerlendirmeleri yapılmıştır. Çalışma grubundaki olgulara ayrıca Aktivitelere Özgü Denge Güven Ölçeği (ADG-6) uygulanmıştır.

Bulgular: Çalışma grubundaki olguların ortalama yaşı 47,12±9,74 yılken, kontrol grubundaki olguların 43,50±8,09 yıldı. Olguların %67’si HBS+, %33’ü HBS- olarak belirlenmiştir. HBS- olanların anlamlı şekilde ADG-6 skorlarının daha yüksek olduğu bulunmuştur (p
Del movimiento de los entes naturales a la dinámica transpersonal del viviente humano: ¿quién es el sujeto de percepción?
Authors: Larison Mariana
Published: December 2021

Phénoménologie de la perception es, sin duda, una de las obras más potentes del pensamiento francés del siglo XX. Allí se plantea una pregunta antigua y novedosa al mismo tiempo, en el cruce de la filosofía fenomenológico-existencial con diversas disciplinas que se ocupan del viviente humano: ¿quién es el sujeto de percepción? Merleau-Ponty responderá en esta obra ya clásica: el cuerpo vivido. Éste será, a su vez, caracterizado como un tipo particular de movimiento, que, en el camino de la fenomenología existencial, adquiere la forma de un movimiento intencional, de una trascendencia y, finalmente, de un movimiento de temporalización que es, en términos husserlianos, la propia subjetividad. Tomando como punto de partida estos análisis, buscaremos desarrollar en este trabajo la tesis según la cual el cuerpo vivido debe comprenderse, en Phénoménologie de la perception, como un movimiento subjetivo transpersonal. Para desarrollar esta idea, partiré de un panorama general sobre el problema de la relación entre cuerpo, movimiento y vida frente al cual Phénoménologie de la perception se presenta como una continuidad y como una ruptura. En segundo lugar, presentaré los conceptos fundamentales que conducen a la concepción merleau-pontyana del cuerpo vivido como movimiento subjetivo para, en tercer lugar, centrar mi lectura en las posibilidades abiertas por este análisis de la experiencia corporal que denomino transpersonal.
Walter Benjamin, la embriaguez urbana y el despertar político de las masas
Authors: Michalski Nahuel
Published: December 2021

Partiendo de las tensiones conceptuales entre las obras tempranas y las de madurez de Walter Benjamin, el presente trabajo propone abordar sus reflexiones en torno a la crisis moderna de la experiencia  política en el marco de la sociedad de masas a partir de dos perspectivas que involucran la noción de imagen, a saber: la corporal-perceptiva presente en sus referencias a la vida urbana y referida a afecciones psicofísicas como el olvido, el shock y la ensoñación, y la histórico-memoriosa desarrollada a partir de la tardía noción de imagen dialéctica íntimamente relacionada con las ideas de despertar y de acción política en clave de rememoración. Desde aquí, se intentará mostrar la importancia que la categoría de imagen y el par olvido (ensoñación) - recuerdo (despertar) adquieren en el pensamiento benjaminiano a la hora de abordar el problema moderno en torno a la degradación de la experiencia política.
Cahit Sıtkı Tarancı’nın “Gençlik Böyledir İşte” Şiirinin Gençlik Algısı Bağlamında Çözümlemesi
Authors: DURUKOĞLU Salim
Published: December 2021

İnsan gençliğinde yaşar, yaşlandığında ya da yaşlandıkça anlar. Bu bir genel kabuldür ve insan gerçeğidir. Aklın başa gelmesi, Cahit Sıtkı’nın Otuz Beş Yaş şiirinde söylediği dizeler üzerinden gidersek, suyun insanı boğduğu, ateşin yaktığı gibi temel ve sıradan gerçekleri bile insanın bilgiden bilince dönüştürebilmesi ancak yolun yarısı olan otuz beş yaşı devirmesi / olgunlaşması ile mümkün olabilecektir. Yaş, yaşlanana bilgelik de katar. Gençliğinde yaşayan, yaşlandığında anlayan insanları, zihnen uyanık tutmak, bilgi ve bilinç sahibi olarak yarınlara hazırlamak, sanatsal olarak eğitmek, geçmişin deneyimlerini gelecek kuşaklara aktarmak için edebiyat, en iyi araçlardan biridir. Bu bağlamda Cahit Sıtkı Tarancı’nın “Gençlik Böyledir İşte” adlı şiiri, bir kuşağın deneyimlerini, duygusal ve düşünsel dünyası ile algısını; sonraki kuşağa aktarmak, onları düşündürmek, bilinçlendirmek, kendine getirmek, varoluşlarını sorgulatmak, zamanın ve gençliklerinin değerini fark ettirmek için anılması gereken önemli ve öncelikli edebi metinlerdendir. Bu yazı, söz konusu şiiri, biçim ve içerik özelliklerini incelemek, şairi Cahit Sıtkı’nın edebi portresinden de yararlanarak, çözümlemek, öncelikle hedef kitlesi gençlere hatırlatmak için kaleme alınmıştır. Gençlik konusunun ve pişmanlık duygusunun / temasının işlendiği bu şiir, gençlere, gençliklerini heba etmemeleri, dolu dolu yaşamaları noktasında edebi bir uyarıdır. Bu araştırmada, nitel araştırma desenlerinden doküman incelemesi yöntemi kullanılmıştır.
Havaalanlarında Müşteri Memnuniyetinin Sağlanması: Van Ferit Melen Havaalanı Örneği
Authors: KIPÇAK Mehtap , UYAR Burak
Published: December 2021

Günümüzde yolcu talepleri açısından büyük bir artış yaşanan hava yolu taşımacılığında müşteri memnuniyetinin doğru şekilde sağlanabilmesi, havayolları işletmeciliğindeki gelişimi daha da hızlandıracak bir olgu olarak ele alınmaktadır. Çalışmamızda, belirlenen tarih aralığında, Van Ferit Melen Havalimanı’nı kullanan toplam 6000 yolcu arasından 300 müşterinin gönüllü katılımıyla anket yapılıp memnuniyet durumları incelenmiştir. Van Ferit Melen Havalimanı’ndan seyahat eden bireylerin memnuniyetini etkileyen faktörlerin başında, gelir ve eğitim durumlarının önemli bir yere sahip olduğu, meslek gruplarının da Van Ferit Melen Havalimanı’ndan seyahat etme durumu üzerinde önemli etkisinin olduğu tespit edilmiştir. Havayolu müşterilerinin memnuniyet durumları ve bu durumlar üzerinde etkili olan faktörlerin, müşteri gözünden ele alınarak havayolu yolcu taşımacılığındaki memnuniyet unsurlarının geliştirilmesi, memnuniyetsizliğe sebep olan unsurların ortadan kaldırılması, tespit edilen hususların literatüre kazandırılarak işletmeler tarafından değerlendirmeye alınıp sektörün daha iyi bir hale getirilmesi amaçlanmıştır.