bluuebunny/crossref_metadata_2025 huggingface dataset:
A Personalized, Transdiagnostic Smartphone App (Mello) Targeting Repetitive Negative Thinking for Depression and Anxiety: Qualitative Analysis of Young People’s Experience (Preprint)
Authors: Valentine Lee , Arnold Chelsea , Nicholas Jennifer , Malouf Jessi , Alvarez-Jimenez Mario , Bell Imogen H
Published: July 2024

BACKGROUND

The increasing rates of mental health challenges among young people highlight an urgent need for accessible and effective treatment. However, current mental health systems face unprecedented demand, leaving most young people globally with unmet mental health needs. Smartphones present a promising solution to this issue by offering in-the-moment support through innovative just-in-time adaptive interventions, which provide support based on real-time data.

OBJECTIVE

This study explores young people’s experiences with Mello, a just-in-time adaptive intervention that focuses on the transdiagnostic mechanism of repetitive negative thinking (RNT), a significant factor contributing to youth depression and anxiety.

METHODS

Semistructured qualitative interviews were conducted with 15 participants aged 16 to 25 years, all of whom had previously participated in a pilot randomized controlled trial of Mello. Of the 15 participants, 9 (60%) identified as women, 4 (27%) as men (including 1 transgender man), and 2 (13%) as nonbinary. Interviews focused on participants’ experiences with the Mello app, factors influencing engagement, perceived benefits and limitations, and suggestions for future improvements. Thematic analysis was used to analyze the data.

RESULTS

The analysis identified three superordinate themes: Mello as a tool for intentional reflection; doing therapy your own way; and barriers to engagement during low mood, anxiety, and RNT. Theme 1 explored young people’s experiences of how the app facilitated active management of negative thoughts and supported the development of reflective habits, contrasting with their typical strategies of avoidance or resistance. Theme 2 highlighted the value of the app’s self-guided nature, with a particular focus on its flexibility and accessibility, particularly when compared to traditional face-to-face therapy. Finally, theme 3 addressed barriers to engagement, particularly during emotionally difficult times, with participants reporting feeling “stuck” in their negative thoughts. To mitigate these challenges, participants suggested incorporating gamification elements, such as progress-tracking visuals, to enhance motivation and increase engagement with the app.

CONCLUSIONS

Our findings underscored the value of Mello in promoting intentional engagement and reflection with RNT, consistent with prior research that emphasizes the effectiveness of tailored interventions. Although some users valued the self-guided nature of the application, others encountered difficulties with motivation. Future research should explore strategies to enhance engagement for young people with low mood and motivation, such as co-design methodologies, advanced personalization features, and gamification techniques.
Using Machine Learning to Predict the Duration of Atrial Fibrillation: Model Development and Validation (Preprint)
Authors: Shimoo Satoshi , Senoo Keitaro , Okawa Taku , Kawai Kohei , Makino Masahiro , Munakata Jun , Tomura Nobunari , Iwakoshi Hibiki , Nishimura Tetsuro , Shiraishi Hirokazu , Inoue Keiji , Matoba Satoaki
Published: July 2024

BACKGROUND

Atrial fibrillation (AF) is a progressive disease, and its clinical type is classified according to the AF duration: paroxysmal AF, persistent AF (PeAF; AF duration of less than 1 year), and long-standing persistent AF (AF duration of more than 1 year). When considering the indication for catheter ablation, having a long AF duration is considered a risk factor for recurrence, and therefore, the duration of AF is an important factor in determining the treatment strategy for PeAF.

OBJECTIVE

This study aims to improve the accuracy of the cardiologists’ diagnosis of the AF duration, and the steps to achieve this goal are to develop a predictive model of the AF duration and validate the support performance of the prediction model.

METHODS

The study included 272 patients with PeAF (aged 20-90 years), with data obtained between January 1, 2015, and December 31, 2023. Of those, 189 (69.5%) were included in the study, excluding 83 (30.5%) who met the exclusion criteria. Of the 189 patients included, 145 (76.7%) were used as training data to build the machine learning (ML) model and 44 (23.3%) were used as test data for predictive ability of the ML model. Using a questionnaire, 10 cardiologists (group A) evaluated whether the test data (44 patients) included AF of more than a 1-year duration (phase 1). Next, the same questionnaire was performed again after providing the ML model’s answer (phase 2). Subsequently, another 10 cardiologists (group B) were shown the test results of group A, were made aware of the limitations of their own diagnostic abilities, and were then administered the same 2-stage test as group A.

RESULTS

The prediction results with the ML model using the test data provided 81.8% accuracy (72% sensitivity and 89% specificity). The mean percentage of correct answers in group A was 63.9% (SD 9.6%) for phase 1 and improved to 71.6% (SD 9.3%) for phase 2 (P=.01). The mean percentage of correct answers in group B was 59.8% (SD 5.3%) for phase 1 and improved to 68.2% (SD 5.9%) for phase 2 (P=.007). The mean percentage of answers that differed from the ML model’s prediction for phase 2 (percentage of answers where cardiologists did not trust the ML model and believed their own determination) was 17.3% (SD 10.3%) in group A and 20.9% (SD 5%) in group B and was not significantly different (P=.85).

CONCLUSIONS

ML models predicting AF duration improved the diagnostic ability of cardiologists. However, cardiologists did not entirely rely on the ML model’s prediction, even if they were aware of their diagnostic capability limitations.
Teacher Motivation under Chhukha Dzongkhag
Authors: Dorji Ten
Published: July 2024

Teacher well-being and motivation play important roles in teacher and student experiences at school. When teachers fair well and are motivated to teach, they are more effective in their teaching. Fewer teachers leave the profession and they promote motivation and achievement among their students. This study investigated teacher motivation and factors affecting teachers’ motivation with the aim of advancing our understanding of the two constructs as well as finding out how they can be promoted among teachers. Study one involved motivation and testing of the attitude of teachers which measured 12 factors of teacher motivation and tested the attitude of teachers. Among a sample of 50 school teachers, results revealed that the new measure functioned similarly across the different demographic groups in the sample. The 12 factors of teacher motivational and testing of the attitude of teachers also revealed that attitude towards the profession is not that negative. Study two involved job satisfaction of teachers. The study on job satisfaction revealed that teachers in general are not satisfied with their profession. Study three involved examining importance of motivation. The findings showed that teachers’ motivation is the key to the success for student engagement and instructional strategies. Study four was associated with major motivational factors affecting teachers in schools. It presented that the motivation is the key to making teachers happy and do their best. Overall findings from the study revealed the significance of the basic psychological needs (autonomy, competence, and relatedness) in predicting teacher well-being and self-efficacy. Taken together, the four studies helped to improve our understanding of the important variables of teachers’ motivation. Implications of the findings for both research and practice are also discussed. For instance, major motivational factors like training opportunity, salary and perks, conducive working school environment and workload to mentioned a few, if taken care, will minimize the teacher attrition rate and will also address the issue of quality of education.
PEMBELAJARAN TAHFIDZ DENGAN METODE TALAQQI VIA APLIKASI ZOOM DAN WHATSAPP (STUDI KASUS SETORAN ONLINE RUMAH TAHFIDZ SMP MA'ARIF NU 1 WANAREJA)
Authors: Latifah Ainiyatul , Nurasih Wiji , Waliko  , Rasidin Mhd. , Witro Doli
Published: July 2024

Since entering the beginning of 2020, the Covid-19 outbreak has rapidly spread to various parts of the world, including Indonesia. Therefore, everyone must keep their distance from each other to avoid transmission and break the chain of the virus. This situation requires the government to impose restrictions on community activities on a large scale, including in this case the restrictions on interaction in the education sector at the Tahfidz House of SMP Ma'arif NU 1 Wanareja. All learning activities must be transferred to the online system (online) or online, as well as the student's tahfidz program. Deposits for memorizing Al-Qur'an which are usually done in talaqqi in front of ustadz/ustadzah are now made through Zoom and Whatsapp media. This study aims to provide an overview of how an effort to learn Al-Qur'an must always run even in very difficult conditions. The results of this study indicate that Zoom is used for interpretation learning which requires delivering presentations (video calls), while Whatsapp is used for memorizing deposits through voice notes.
Belajar Sebagai Kehendak Manusia (Masyiatul I'bad) dalam Mendapatkan Ilmu Pengetahuan
Authors: Rachman Taofik Andi , Nuwadjah Ahmad  , Andewi Suhartini
Published: July 2024

The human will to choose is a gift that Allah has given to them. Since early life, humans have the potential to choose certain attitudes in life. With this will of choice, human can be in goodness and also man can fall into sin. The factors that can influence this will are human reason and revelation sent down by Allah Almighty. The relevance of the human will to gain knowledge is to study hard to master the knowledge that humans need. This paper is compiled from a literature study that contains the human will and theological reviews of the human will in obtaining knowledge. The data is compiled, analyzed, and concluded so as to get an overview of the views of Islamic theology in gaining knowledge. The results of the study show that knowledge is essentially a sustenance from Allah swt. As Allah's sustenance, humans are required by Sharia to earn it seriously. Studying diligently is a human effort to master knowledge. This human will is an important matter for humans in obtaining and developing knowledge.
Profesionalisme Guru dalam Menumbuhkan Nilai Karakter Siswa Berbasis Nilai-Nilai Budaya 5S (Senyum, Sapa, Salam, Sopan, Santun) di SMK 1 Muhammadiyah Kasihan Bantul Yogyakarta
Authors: Yusutria  , Sutarman
Published: July 2024

The cultivation of 5S culture in instilling religious character imbues the teachings of Islamic values. So that professional teachers help grow the character values "‹"‹of students who are still lacking and need to be instilled in order to get used to and have religious characters that are in accordance with Islamic teachings and national education goals. The aim is to determine the professionalism of teachers in growing religious character based on 5S culture. This research is quantitative with a population of 45 students in class XI SMK 1 Muhammadiyah Bantul Yogyakarta. Collecting information using questionnaires and documentation. The results of the research on the results of the growth of character values "‹"‹are 100% teachers provide socialization and role models, 80% warmly welcome students, 100% teachers say hello, 90% give advice if there are mistakes, 100% teachers give awards to students who apply S5, 100% teachers are careful in speaking, 80% of teachers apply S5, 100% of teachers establish good cultural relations with parents and the community.
Mixed Methods of Learning in Schools: Reshaping comprehensive education in Synchronous and Asynchronus
Authors: Lastari Riska , Lismawati  , Heru Wibowo  , Totong Heri
Published: July 2024

This research was conducted to determine whether there is influence of the Synchronous and Asynchronous approach methods on student learning outcomes. This research was conducted at SMAN 3 Tangerang. The population in this study were 310 students and 175 students were taken as a sample. This research is a quantitative research and uses a questionnaire in collecting data. The results of the questionnaire data were processed using the IMB SPSS Statistics application version 25. The results of this study indicate that there is a positive influence in online learning using the Synchronous and Asynchronous approach methods on student learning outcomes. Even though the magnitude of this influence, based on the results of the analysis the coefficient of Determination (R2) is relativaly low, namely 0.292 or 29.2 %.
APPROACHES TO THE STUDY OF THE FUNCTIONING OF THE COMPLEX OF CREATIVE INDUSTRIES IN THE ECONOMY
Authors: Makieva Irina ,   Committee of the State Duma of the Federal Assembly of the Russian Federation on Economic Policy
Published: July 2024

The increase in the share of creative industries in the GDP of the Russian Federation up to 6% over the last year indicates the need to determine a methodological basis for studying these industries. The currently prevailing sectoral approach does not allow to give details of the internal connections of the creative industries and, accordingly, does not contribute to the unambiguous determination of the object and subject of this research. Formulation of the scientific research problem. Sectoral analysis and calculation of a set of general economic indicators does not allow to take into account the nature of relations between participants in creative industries and the complexity of the formation of a creative product. Well-known metrics, including quantitative and structural analysis of organizations according to the codes of All-Russian Classifier of Types of Economic Activity (RCEAP), calculations of value added and marginality level do not allow to obtain comparable results for all kinds of activities classified as creative industries. In this regard, the scientific task of the study was formulated consisting of identifying approaches to understanding the functioning of creative industries from the point of economic activity, allowing to overcome the identified limitations. Results achieved. The complex of creative industries, operating in a constantly modifying structure of collaborations, creative projects, acts of short-term cooperation between organizations and individual participants, theoretically represents a network structure and can be most fully studied within the context of the existing network methodology. The development of network analysis makes it possible to study the functioning of creative industries as a set of entities acting in a complementary manner. Conclusions. Understanding the complex of creative industries as a network structure allows to consistently solve the problem of determining the composition and structure of a creative network, determine the parameters of participants based on the possibilities of dominance, coordination of networks participants, as well as define the nature of connections between participants in a creative networks and calculate the indicators that determine the features of the formation of consumer value, and correlate with certain parts of the creative network, which will ultimately make it possible to determine the most effective tools for stimulating the development of network structures of industries and increase the benefits of their formation within regional and national economies
Novel Cavity Disinfectants and Their Effects: A Review
Authors: Alp Şemsi
Published: July 2024

Objective: This review aims to assess the efficacy of various materials and systems, including Chlorhexidine Digluconate, Benzalkonium Chloride, Hydrogen Peroxide, Sodium Hypochlorite, Iodine, Aloe Vera, Hyaluronic Acid, Propolis, Ozone, Photoactivated Disinfection, Lasers, and Antibacterial Dentin Adhesives, in cavity disinfection.
Methods: A comprehensive review of literature and studies was conducted to evaluate the effectiveness of the mentioned materials and systems for cavity disinfection.
Results: The review revealed diverse effects of Chlorhexidine Digluconate, Benzalkonium Chloride, Hydrogen Peroxide, Sodium Hypochlorite, Iodine, Aloe Vera, Hyaluronic Acid, Propolis, Ozone, Photoactivated Disinfection, Lasers, and Antibacterial Dentin Adhesives on cavity disinfection. The findings highlight the potential of these agents and technologies in enhancing disinfection protocols in dental practice.
Conclusion: This review underscores the importance of exploring various materials and systems for cavity disinfection to improve dental treatment outcomes. Further research and clinical trials are warranted to validate the efficacy and safety of these agents and technologies in dental settings.
Bonhoeffer e Lutero
Authors: Wachholz Wilhelm , Brüning Djonata
Published: July 2024

O presente artigo tem como objetivo promover o diálogo entre a teologia Bonhoeffer e de Lutero a partir do problema da superioridade racial. Ele reforça a tese que a correta interpretação da teologia de Bonhoeffer precisa sempre ser concebida em seu diálogo com a teologia de Lutero. Trata-se de uma análise de natureza literária. Constata-se um duplo movimento, a saber, que a teologia de Lutero forneceu a base para a reflexão e ação de Bonhoeffer quanto à questão racial e, ao mesmo tempo, Bonhoeffer corrigiu os equívocos interpretativos da teologia de Lutero e atualizou sua herança teológica para a atualidade. Deste modo, o diálogo entre Bonhoeffer e Lutero é (sempre) necessário e atual porque traz referenciais para o discernimento teológico.
grande baile de máscaras do mal”
Authors: Schaper Valério
Published: July 2024

Partindo de um texto redigido por Dietrich Bonhoeffer na virada 1942 para 1943, em que ele analisa a década transcorrida entre a ascensão do Partido Nacional-Socialista dos Trabalhadores Alemães e o período de redação do texto, investiga-se que tipo de ética ele propõe para aquele período de exceção em que todas as referências institucionais e culturais desapareceram. Examina-se parcialmente o texto da ética em que Bonhoeffer trabalhava quando foi preso pelas forças nazistas. Num segundo momento, a reflexão proposta pelo autor é colocada em contexto ampliado, lançando mão das contribuições de pessoas que também se envolveram no esforço de pensar aquele momento, desentranhando daquela situação a noção de responsabilidade como única ação possível em um estado de exceção. Em um momento em que o tema do fascismo se coloca novamente na ordem do dia este exame a questão responsabilidade cobra novamente sua hora.
Palavas-chave: Estado de Exceção. Fascismo. Ética. Responsabilidade.
Traditional Productions and Neo-Liberal Market Challenges for Cultural Identities: A study of Manipuri Indigenous Weavers in Bangladesh
Authors: Singha Rajmoni ,   North South University, Dhaka
Published: July 2024

This study investigates how the Manipuri weaving community in Bangladesh strives to maintain their livelihoods and ethnic identity while preserving their traditional handloom weaving customs. The community’s main professions are agriculture and weaving. The Manipuri, an ethnic group residing in the Greater Sylhet region of Bangladesh, produces handloom products that are deeply intertwined with their culture and identity. This paper explores how Manipuri weaving processes and products embody their cultural values and contribute to the community’s identity in Bangladesh. Weaving holds significant cultural importance within Manipuri society, particularly for women, and later becomes a crucial aspect of their daily livelihoods in Bangladesh. The paper analyses the practical constraints that bind the Manipuri weaving practices and the preservation of their identity in Bangladesh. The study reveals that many weavers lack literacy and connections with government agencies. Additionally, modern textile factories mass-produce counterfeit “Manipuri” handloom items, distorting the authentic cloth motifs and patterns that hold historical, identity, and cultural significance. Consequently, Manipuri weavers face many challenges in dealing with these imitation products. A qualitative approach was employed in this study.
Gender, Identity and Conflict: Militant Women and Feminist Assertion in In the Shadow of a Sword: The Memoir of a Woman Leader in the LTTE by Thamizhini
Authors: Jenisha T. ,   Central University of Tamil Nadu, India, Boopathi P. ,   Central University of Tamil Nadu, India
Published: July 2024

This article attempts to study the condition of militant women in conflict zones by exploring how Sri Lankan militant women who actively engaged themselves in the Sri Lankan civil war for more than two decades, were reifying their radical feminist self, amidst the adversities of war and its strenuous terrain. Further, the article attempts to study the life narrative In the Shadow of a Sword: The Memoir of a Woman Leader in the LTTE by Thamizhini, translated by Nedra Rodrigo, which depicts a realistic way of dealing with the struggles of war, with Thamizhini focusing primarily on the feminist aspects of the movement, including how female cadres evolved into formidable women over the course of the struggle, and how it all fell apart at the end of the war. It also tries to look into the militant identity that the Sri Lankan Tamil women built during the course of the war and the identity crisis that they have gone through in the aftermath of the war. It examines the positionality of female soldiers in conflict, peace negotiations, and national politics, by foregrounding how female combatants in the Liberation Tigers of Tamil Eelam (LTTE) transition from a female to a feminist phase during the conflict, and how this transition inverses in the aftermath. Furthermore, the article intends to investigate Thamizhinis past experiences and memories and how she came to terms with her past. This article aims to analyse the development of female soldiers identities inside the LTTE, from their initial identification as “female” with feminine traits to their acceptance of a more “feminist” stance within the movement and throughout the course of the war by drawing on Toril Mois (1989) conceptions of female, feminine, and feminist identities. This framework further sheds light on the complex processes of constructing identities and agency among these women, extending the relevance of Mois idea beyond the confines of womens literature and comprehending how the genre of life narrative represents and negotiates varied aspects of subdued gender identities.
Effects of the estimated inversion strength and aerosols on monthly variations of subtropical marine stratocumulus to the west of Africa
Authors: Soriano Waren Dale Rosario , Dinh Tra , Bellon Gilles
Published: July 2024

Satellite and reanalysis data over 20 years (2003‒2022) are used to
study how the estimated inversion strength (EIS), other known
thermodynamic variables, dust aerosols (DAs) and biomass-burning
aerosols (BBAs) affect the monthly variations of marine stratocumulus
(MSc) to the west of Canary Islands and Namibia. Although EIS is thought
to be the main predictor of low-cloud cover (LCC), the seasonal cycles
of EIS and LCC differ significantly in the Canary MSc region. In linear
regression models, adding DA optical depth as a predictor significantly
improves the prediction of LCC across all seasons and almost everywhere
in the region compared to using EIS alone. In fact, DAs contribute more
than EIS to the LCC maximum in boreal summer, reducing the error by up
to 11%. In this season, large amount of DAs are transported by the
African Easterly Jet from the Sahara to the Canary MSc region. DAs can
increase LCC as they are effective cloud condensation nucleii (CCN).
Other known thermodynamic predictors of LCC can reduce the error, but by
far less effectively than DAs. BBAs also improve the prediction of LCC
in the region, but less so than DAs, suggesting that BBAs are less
effective as CCN. Our results indicate the insufficiency of EIS as a
predictor of LCC, particularly in the Canary MSc region, a limitation
that aerosols as CCN help to address.
Paradigmas económicos, emergencia socioambiental y procesos de territorialización en los corredores biológicos en Villavicencio 1980-2015
Authors: Quintero Velandia Marlon Fabián , Ramírez Ramírez Angie Daniela , Ochoa Amaya Juan Manuel
Published: July 2024

Este trabajo de investigación analiza en conjunto el modelo desarrollista de producción junto con sus afectaciones ambientales devenidas a partir de los distintos modelos económicos en el periodo 1980 a 2015. Es a su vez es el resultado del análisis y estudio de las presiones territoriales emanadas a partir de la década del 50 del siglo XX se han ejercido sobre el área de monte aledaña al corredor biológico Zuria en Villavicencio, y que han generado una disminución del dosel de bosque y pérdida de biodiversidad en el sector. Esta relación de los temas ambientales ligados a prácticas derivadas del modelo desarrollista de producción, están enfocadas a responder a la pregunta central de investigación sobre ¿Cómo los actores sociales, a través de sus actividades socioeconómicas y sus perspectivas socioambientales han reconfigurado el territorio conformando una frontera socioambiental en el corredor biológico Zuria, Villavicencio en el periodo 1980-2015? Para ello se incorporó una metodología de investigación cualitativa de tipo analítico descriptivo, pues precisamente este tipo de investigación puede tomar un punto de partida o retroceder en él hasta encontrar las conexiones entre hechos ya conocidos o evidentes. Es así como se llegó a la conclusión que los actores sociales que allí habitan han realizado practicas sociales y económicas, concordantes con el modelo de desarrollo, que han diezmado la flora y fauna del corredor biológico Zuria, y que a su vez son incompatibles con el uso del suelo.
Deciphering the connection between microvascular damage and neurodegeneration in early diabetic retinopathy
Authors: Yang Qian , Yasvoina Marina , Olvera-Barrios Abraham , Mendes Joel , Zhu Meidong , Egan Cathy , Tufail Adnan , Fruttiger Marcus
Published: July 2024

Diabetic retinopathy (DR), a common diabetes complication leading to vision loss, presents early clinical signs linked to retinal vasculature damage, affecting the neural retina at advanced stages. However, vascular changes and potential effects on neural cells before clinical diagnosis of DR are less well understood. To study the earliest stages of DR we performed histological phenotyping and quantitative analysis on postmortem retinas from 10 donors with diabetes and without signs of DR (such as microaneurysms and haemorrhages), plus 3 controls and 1 DR case, focusing on capillary loss in the deeper (DVP) and superficial vascular plexuses (SVP) and neural retina effects. The advanced DR case exhibited profound vascular and neural damage, whereas the ten randomly selected donors with diabetes appeared superficially normal. The SVP was indistinguishable from the controls. In contrast, over half of the retinas from donors with diabetes showed capillary dropout in the DVP and increased capillary diameter. However, we could not detect any localised neural cell loss in the vicinity of dropout capillaries. Instead, we observed a subtle pan-retinal loss of inner nuclear layer (INL) cells in all diabetes cases (p<0.05), independent of microvascular damage. In conclusion, our findings demonstrate a novel histological biomarker for early-stage diabetes-related damage in human postmortem retina, common in people with diabetes before clinical DR diagnosis. Furthermore, the mismatch between capillary dropout and neural loss questions the notion of microvascular loss directly causing neurodegeneration at the earliest stages of DR, so diabetes may affect the two readouts independently. article Highlights · The study the earliest stages of diabetic retinopathy (DR), we histologically analysed postmortem retina from donors with diabetes but no DR. · We found in many donors vascular damage in the deeper plexus of the retinal vasculature in the absence of changes in the superficial plexus or other manifest DR signs. · We also found pan-retinal neural loss, not spatially correlated with local microvascular nonperfusion and even in tissue with no vascular damage. · Retinal neurodegeneration seems therefore not directly linked to microvascular dropout at the earliest stage of DR. · Deeper plexus perfusion can be a useful early biomarker to assess DR.
Insulin regulation of lysine and α-aminoadipic acid dynamics and amino metabolites in insulin-resistant and control women
Authors: Y Chang Alice , K Asokan Aneesh , Z. Lalia Antigoni , Sakrikar Dhananjay , R. Lanza Ian , Petterson Xuan-Mai , Sreekumaran Nair K.
Published: July 2024

Insulin is a key regulator of amino acids (AAs) metabolism. Many plasma AAs, including lysine and its metabolite, α-aminoadipic acid (α-AA), a predictor for developing diabetes, are elevated in insulin resistance. In 18 insulin-resistant (IR) over-weight women with polycystic ovary syndrome compared to 12 lean controls, high physiological insulin during a euglycemic clamp failed to normalize many elevated AA metabolites, including branched-chain and aromatic AA, alpha-amino-butyric acid, and lysine, but normalized α-AA. To understand the underpinning of differential responses of lysine and its metabolic product α-AA to high physiological insulin in IR compared to controls, we developed a kinetic model utilizing [α-15N1] lysine and [13C1] α-AA as tracers and measured the two tracers simultaneously in α-AA by innovative mass spectrometry. High insulin increased lysine conversion to α-AA in IR and controls but failed to normalize plasma lysine concentrations in IR due to a decrease in lysine metabolic clearance rate (MCR). In contrast, despite higher conversion rates of lysine to α-AA by high insulin, α-AA concentration decreased in IR because of the sustained greater MCR of α-AA. The abnormal AAs and metabolites, even while on high physiological insulin, could potentially explain many functional derangements in IR.
Overexpressed Poldip2 incurs retinal fibrosis via the TGFβ1/SMAD3 signaling pathway in diabetic retinopathy
Authors: Ji Zhiyu , Lin Siyu , Gui Siyu , Gao Jie , Cao Fan , Guan Yiming , Ni Qinyu , Chen Keyang , Tao Liming , Jiang Zhengxuan
Published: July 2024

Retinal fibrosis is one of the major features of Diabetic retinopathy. Our recent research has shown that Poldip2 can affect early DR through oxidative stress, but whether or not Poldip2 would regulate retinal fibrosis during DR development is still enigmatic. Here, Diabetic Sprague-Dawley (SD) rats were induced with STZ and treated with AAV9-Poldip2shRNA, while human retinal pigment epithelial cells (ARPE-19) were treated with high glucose (HG) or Poldip2 siRNA. We identified that in STZ-induced DR rats and ARPE-19 treated with high glucose, the expression of Poldip2, TGFβ1， P-SMAD3/SMAD3, MMP9, COL-1, FN, and CTGF increased while the expression of Cadherin decreased. However, deleting Poldip2 inhibited the TGF-β1/SMAD3 signaling pathway and attenuated the above protein expression in vivo and in vitro. Mechanistically, we found that Poldip2 promotes the activation of SMAD3, and facilitates its nuclear translocation through interacting with it, and significantly enhances the expression of fibrosis makers. Collectively, it was identified that Poldip2 is a novel regulator of DR fibrosis and it is expected to become a therapeutic target for PDR.
Response Surface Methodology (RSM) for Optimization Carbonization Parameters of Exhausted Coffee Husk for Iron Removal from Aqueous Solution
Authors: Puari Aninda T. , Yanti Nika R. , Sari Nurmala , Rusnam Rusnam
Published: July 2024

In this study, biochar derived from exhausted coffee husk (ECH) was used as biosorbent for removing Iron (II) from aqueous solution. The aim of this study was to improve the biosorption capacity of the biosorbent from agricultural solid waste and its usability for Fe²⁺ removal. The biosorption performance of ECH biochar was optimized through carbonization parameters: temperature, time, and temperature gradient. Response Surface Methodology (RSM) based on multivariate analysis was employed to evaluate the biosorption performance of ECH biochar for Fe²⁺ biosorption. The optimum performance predicted through Box-Behnken design experiment. The optimal combination of the three parameters was 549.37°C, 1.98 h and 21.98°C/min. At the optimal condition the removal efficiency (RE) was predicted to be 107.01% and biosorption capacity (qt) was 5.11 mg/g. SEM-EDX, FT-IR and XRD analysis were conducted in this study to evaluate the biosorption mechanism of ECH biochar on the iron ion. The results showed that ion exchange existed on the surface of the ECH biochar during the biosorption. Additionally, the presence of functional groups on the ECH biochar surface responsible for Fe(II) binding. Overall, the findings of this study suggested an eco-friendly strategy for optimizing the removal of Iron (II) from polluted water by the biosorption onto ECH biochar. Keywords: Biochar, Biosorption capacity, Box-Behnken design, Temperature, Time
ANALISIS KEBIJAKAN KESEHATAN DALAM MENINGKATKAN MUTU PELAYANAN KESEHATAN PUSKESMAS DI KOTA MEDAN
Authors: Agung Saputra  , Siti Hajar  , Mila Trisna Sari
Published: July 2024

Puskesmas sebagai salah satu FKTP (Fasilitas Kesehatan Tingkat Pertama) yang difungsikan sebagai gatekeeper dalam pelayanan kesehatan yang dituntut untuk menyelenggarakan pelayanan kesehatan untuk masyarakat secara adil, merata, berkualitas dan memuaskan masyarakat. Namun, kinerja Puskesmas yang ada di Kota Medan, tidak seluruhnya menyelenggarakan pelayanan kesehatan dengan baik dan benar sesuai dengan standar pelayanan kesehatan yang diatur dalam peraturan yang berlaku. Dengan demikian, untuk menghasilkan kinerja yang optimal dan berkualitas maka seluruh sumber daya yang ada sebagai input dalam pelayanan kesehatan di Puskesmas Kota Medan harus dapat disesuaikan dengan standar dan kode etik profesi di bidang kesehatan. Tujuan penelitian ini untuk mengetahui kebijakan pelayanan kesehatan berbasis kinerja dalam meningkatkan kepuasan masyarakat pada Puskesmas Kota Medan. Metode yang digunakan dalam penelitian ini adalah metode mixed methode yang menggabungkan antara kualitatif dan kuantitatif (penelitian kombinasi). Penelitian ini menghasilkan mutu pelayanan kesehatan di Puskesmas Kota Medan tergolong sangat bagus berdasarkan tingkat kepuasan masyarakat terhadap pelayanan kesehatan yang diperoleh, meliputi unsur keandalan (87%), ketanggapan (88%), kepastian (77%), empati (84%) dan tangible (77%).
DIGITALISASI PELAYANAN PUBLIK : KETIDAKSIAPAN MASYARAKAT DALAM PENGGUNAAN APLIKASI IDENTITAS KEPENDUDUKAN DIGITAL DI BOJONEGORO
Authors: Siti Marfu'ah  , Ana Kumalasari  , Ida Swasanti
Published: July 2024

ABSTRAK
Dengan penerapan teknologi digital dalam pelayanan publik, terutama melalui penggunaan aplikasi Identitas Kependudukan digital di Bojonegoro, terdapat banyak pro dan kontra. Dengan menerapkan e-government, pemerintah harus meningkatkan pelayanan publik. Studi kasus Identitas Kependudukan Digital Kabupaten Bojonegoro merupakan salah satu contoh ketidaksiapan masyarakat dalam memasuki era digitalisasi pelayanan publik. Studi ini meningkatkan pemahaman tentang pro dan kontra digitalisasi pelayanan publik, khususnya di Bojonegoro, dan menekankan berbagai masalah yang dihadapi masyarakat. Sukses dalam menerapkan transformasi digital di tingkat lokal bergantung pada kebijakan yang dapat meningkatkan inklusi dan memenuhi kebutuhan masyarakat. Data mining, machine learning, sensor technology, dan service automation merupakan beberapa contoh potensi baru dalam digitalisasi pelayanan publik. Studi kualitatif dengan menggunakan studi kasus Untuk melakukan observasi dan wawancara mendalam dengan para informan di lokasi penelitian, peneliti terjun langsung ke lapangan. Fokus penelitian adalah pada individu yang menggunakan aplikasi IKD khususnya yang tinggal di wilayah Kabupaten Bojonegoro. Hasil penelitian menunjukkan bahwa masyarakat Indonesia, khususnya Bojonegoro, belum siap.
 
Kata kunci: Digitalisasi; E- goverment; IKD; Ketidaksiapan; Pelayanan publik
ABSTRACT
With the application of digital technology in public services, especially through the use of the IKD application in Bojonegoro, there are many pro and contra. By implementing e-government, the government must improve public services. The Bojonegoro Regency IKD case study is an example of the community's unreadiness to enter the era of digitization of public services. This study increases understanding of the pros and cons of digitizing public services, especially in Bojonegoro, and emphasizes various problems faced by the community. Success in implementing digital transformation at the local level depends on policies that increase inclusion and meet community needs. Data mining, machine learning, sensor technology, and service automation are some examples of new potentials in digitizing public service provision. Qualitative study using case studies To conduct in-depth observations and interviews with informants at the research location, researchers went directly to the field. The focus of the study was on individuals using the IKD application, especially those living in the Bojonegoro Regency area. The study shows that Indonesian society, especially Bojonegoro, is not yet ready.
 
Keywords: Digitalization; E-government; IKD; Unreadiness; Public service
Digital Economy and Poverty Reduction in Africa: The Role of Governance Quality
Authors: Rakotondrazaka Tojo Herilanto , Velomasy Yanne Gabriella
Published: July 2024

This research explores the relationship between the digital economy and poverty in Africa, with a focus on the role of governance quality. Utilizing data from 37 African countries from 2009 to 2022, the study employs robust statistical techniques, such as Panel-Corrected Standard Errors and Instrumental Variable Two-Stage Least Squares estimation. The results indicate a significant association between the digital economy index and reduced poverty levels. Additionally, the study highlights the necessity of improving governance quality to maximize the positive effects of digital economic initiatives on poverty alleviation. By elucidating these interrelated dynamics, this research seeks to provide actionable policy recommendations tailored to the unique developmental challenges faced by African countries.
Novel interpretation of the crustal structure and hydrocarbon evolution within the South Caspian and Kura sedimentary basins, Azerbaijan
Authors: Abdullayev N.R. , Guliyev I.S. , Kadirov F.A. , Huseynova Sh.M. , Javadova A.S. , Maharramov B.I. , Mukhtarov A.Sh.
Published: July 2024

The South Caspian Basin, Lower and Middle Kura Basins, onshore Azerbaijan, and Georgia Upper Kura Basin are a genetically linked basin system created in a Mesozoic extensional setting with a complex Cenozoic sediment fill history. Delineating these basins shed new light on understanding the complex geodynamic history of the region between the Black Sea and the Caspian Sea and elucidate the petroleum prospectivity of the region.
Key data used for basin analysis were a series of regional isopach maps, temperature measurements from over 150 onshore and offshore boreholes in Azerbaijan, derived geothermal gradient data, and published surface heat flow data. Taken together, they allowed us to put some constraints on the crustal structure of an area where accurate temperature measurements are limited. An integrated set of offshore and onshore regional isopach maps for the key stratigraphic units from Jurassic to Pleistocene were created. The depth to basement and the crustal thickness across four seismic cross-sectionswere estimated and validatedvia interpretation of isopach maps and gravity and magnetic modeling.
The results encompass the area from the onshore Kura Basin in eastern Georgia to the offshore South Caspian. Several specific regions were differentiated, including a «cold» region in the South Caspian Basin. A reasonable correlation was established between basement depth, crustal thicknesses, and geothermal gradients. The tectonic boundary between these two basins controls the geothermal gradient change and therefore the hydrocarbon potential.
The western margin of the South Caspian Basin represents a long-standing crustal boundary between the South Caspian Basin oceanic crust of the South Caspian Basin and the thicker crust of the Kura basin of the island-arc origin. The Mesozoic evolution of these basins started as a result of an island arc extension in Mesozoic, followed by Cenozoic flexural overprint with rapid burial and significant sediment flux, thus creating suitable conditions for the development of a dynamic petroleum systems in the South Caspian Basin.
PENELITIAN PAJAK DAERAH: STUDI BIBLIOGRAFI 27 TAHUN
Authors: Erfandi Moh. , Lastanti Nadila , Aniyah Shofinatul , Wati Nova Dwi Medya , Herawati Nurul
Published: July 2024

Penelitian ini bertujuan untuk mengkaji penelitian pajak, dengan tema pajak daerah sebagai salah satu indikator perkembangan ilmu pajak di Indonesia. Pajak daerah dikelola oleh provinsi dan kabupaten/kota. Pajak daerah merupakan kontribusi dalam pendapatan asli daerah, dimana pajak daerah mempengaruhi kegiatan penyelenggaraan pemerintah dan bangunan daerah. Penelitian ini menggunakan 194 sampel artikel yang terpublikasi di jurnal terakreditasi SINTA 1 dan 2. Penelitian ini mengklasifikasikan berdasarkan topik penelitian dan metode penelitian. Periode amatan yang digunakan adalah tahun 1997-2023. Hasil penelitian menunjukkan bahwa topik yang paling banyak diteliti adalah ekonomi. Penelitian pajak daerah lebih didominasi oleh paradigma kuantitatif. Penelitian ini juga menemukan bahwa tahun 1997 merupakan tahun pertama artikel pajak daerah dipublikasikan dalam jurnal terakreditasi SINTA 1 dan 2. Implikasi penelitian ini adalah memberikan wawasan mengenai perkembangan penelitian pajak daerah di Indonesia dalam kurun waktu 27 tahun dan memberikan kontribusi pada pustaka akuntansi untuk memahami aspek perpajakan. Selain itu, penelitian pajak daerah masih terbuka untuk diteliti lebih lanjut dengan paradigma kualitatif dan topik penelitian yang masih jarang diteliti.
Minutiöse Planung für ein Mammutprojekt
Authors: Scheurer Steffen , Steeger Oliver
Published: July 2024

Kein Restaurierungsprojekt ist gegen Überraschungen gefeit: Plötzlich stoßen die Fachleute etwa auf Mauerrisse, faule Bodenbalken oder hartnäckigen Schmutz. Doch so wahrscheinlich Überraschungen sind – dies entbindet das Projekt nicht von der Pflicht minutiöser Planung. Beim Schloss Neuschwanstein hat sich dieser Projektmanagement-Grundsatz hervorragend bewährt. Projektleiter Heiko Oehme berichtet über den Umgang mit Überraschungen, über die Koordination der Restaurierung mit dem Besucherverkehr – und darüber, weshalb das erhaltene Bauarchiv des berühmtesten deutschen Schlosses ein fantastischer Glücksfall ist.
Hygienic assessment of weather sensitivity and meteotropic reactions in students
Authors: Ganuzin VM , Baraboshin AT , Serkova OV
Published: July 2024

The issue of weather sensitivity and meteotropic reactions in various population groups depending on the age, place of residence, professional features, and health status is relevant and inadequately covered in scientific literature. The study was aimed to assess weather sensitivity and meteotropic reactions in medical university students of various age groups. Polling of 243 students aged 17–18 and 23–24 years was performed using a tailored questionnaire consisting of 16 questions allowing one to detect weather sensitivity and meteotropic reactions in the respondents. Analysis of the data acquired showed that 53.7% of female and 16.7% of male first-year students had weather sensitivity (р < 0.001). Furthermore, 47.0% of surveyed first-year students and 67.0% of 5–6th-year students complained of various intermittent meteotropic reactions. In first-year students, meteotropic reactions were most often manifested in the decreased performance (76.6%), headache (74.6%), fatigue (70.2%). The weather-sensitive 5–6th-year students more often complained of the bouts of headaches (72.9%), decreased performance (66.7%), sleep disorders (31.2%), and muscle pain (49.6%). Meteotropic reactions occurred in 47.0–67.0% of the surveyed students of various age groups. Thus, when weather sensitivity is detected in students during the medical check-up, further prevention of the meteotropic reaction exacerbations should be tailored based on the medical weather forecasting.
Data Mining for Fraud Detection
Authors:   Salahaddin University – Erbil, Sabah Mamand Samar
Published: July 2024

In the contemporary era, most of the operations in various domains take place through a transparent digital platform. However, there have been instances of fraudulent behavior and transactions leading to loss to individuals or entities. In this context, there is a need for technology-enhanced approaches to detect different kinds of fraud in sectors like banking, insurance, healthcare and e-commerce, to mention a few, for sustainable digitalization. With technological innovations such as the Internet of Things (IoT) and cloud computing, unprecedented applications emerged. This has also brought increased fraud instances. At the same time, Artificial Intelligence (AI) along with data mining, machine learning and deep learning is found to solve problems in the real world. Therefore, it is essential to ascertain the present state of the art in fraud detection. Towards this end, this paper focuses on a systematic review of existing data mining or AI methods used for fraud detection in different domains. The insights of this paper can trigger further research in the area of automatic fraud detection.
The Role of Transparency International in Rationalizing Governance and combating Corruption
Authors:   College of Politic Science_Al Nahrain Uni. – Iraq, Isa Abdulrahman , Kadim Ali ,   Presidency of Kerbalaa Uni. -Iraq
Published: July 2024

اذا ما اردنا في بداية البحث ان نعرف منظمة الشفافية الدولية (Transparency International) والتي هي منظمة غير حكومية تهدف إلى تعزيز الشفافية ومكافحة الفساد في جميع مختلف انحاء العالم ، وتعمل تلك المنظمة بمجالات عدة اذ انها تقوم المنظمة بتنفيذ العديد من الأنشطة والمبادرات الهادفة إلى ترشيد الحكم ومكافحة الفساد، وتلعب دورًا هامًا في تعزيز النزاهة والحوكمة في القطاعين العام والخاص ، ويمكن تلخيص البعض من جوانب اساسية في دور منظمة الشفافية الدولية في ترشيد الحكم ومكافحة الفساد واهمها 1. تقييم العمل ومراقبة اوجه الفساد: اذ انها تعمل على تقييم مستويات الفساد في الدول والعمل على تصنيفها وفقًا لمؤشرات الفساد الدولي الذي تعمل على اصداره بالاعتماد على استطلاعات الرأي وتقارير المؤسسات الدولية، ويوفر صورة عامة عن مستوى الفساد في الدول المختلفة. 2. تعمل المنظمة على بث و تعزيز الوعي حول الفساد وابراز أثره السلبي على التنمية والمجتمعات ، كما انها تقوم بالدعوة إلى تحسين النظم القانونية والتشريعات المتعلقة بالنزاهة والشفافية، وتشجع على اعتماد معايير دولية لمكافحة الفساد. 3. السعي الى بناء القدرات: اذ انها تقدم الدعم والتوجيه والمشورة للحكومات والمؤسسات والمجتمع المدني في تعزيز النزاهة وتطوير استراتيجيات مكافحة الفساد، تقوم بتنظيم ورش العمل والدورات التدريبية وتبادل المعرفة والخبرات. 4. عقد التحالفات والشراكات عبر بناء شراكات قوية مع المؤسسات الحكومية والمنظمات غير الحكومية والقطاع الخاص ووسائل الإعلام والأفراد المهتمين بمكافحة الفساد تعزز المنظمة التعاون الدولي وتبادل المعلومات والأفكار لتعزيز جهود مكافحة الفساد. نشر الشفافية والنزاهة و تعزيز ثقافة الشفافية والنزاهة في القطاعين العام والخاص عبر تشجيع الاعتماد على الممارسات الشفافة وتعزيز حق الوصول إلى المعلومات والرقابة المستقلة