bluuebunny/crossref_metadata_2025 huggingface dataset:
Industrial and scientific-technological integration of the EAEU member-states in the area of remote sensing of the Earth: legal and program framework
Authors: Shugurov Mark Vladimirovich
Published: July 2021

The subject of this research is the legal framework for scientific-technological and industrial cooperation of the EAEU member-states in the area of remote sensing of the Earth, reflected in the provisions of international agreements and acts of the Union bodies. Emphasis is placed on the analysis of the legal nature of the EAEU transnational program for the creation of an integrated remote sensing system, characterized by the author as a promising organizational legal instrument for cooperation and integration. Special attention is given to the factors of its successful implementation. The research is conducted in the context of theoretical and practical aspects of strategic integration of the EAEU in the space sector. The novelty consists in substantiation of the fact that in the conditions of specific state of legal regulation of cooperation of the EAEU member-states in the space sector, the leading role in the mid-term perspective would be played by program control. In turn, it would contribute to the systematic development of general, as well as special legal framework for cooperation in the space sector. The author’s main contribution consists in pursuing correlation between the system of legal and program framework for cooperation in the area of remote sensing of the Earth and the legal model of EAEU, as well as the legal model of scientific-technological and industrial integration.
Competition of world powers in Central Asia
Authors: Iuniushkina Anna Sergeevna , Pon'ka Tat'yana Ivanovna , Shapovalova Kristina Alekseevna
Published: July 2021

This article explores the role of Central Asia in modern conditions, which significantly increases in geopolitical and geoeconomic aspect. Attention is given to the general security challenges of Central Asian countries, as this region requires the coordination of efforts of the leading global actors, as well as Central Asian countries themselves. Security issues associated with vulnerability of Central Asian countries to natural disasters and emergency situations that may occur as a result of territorial disputes, ethnic violence, drug trafficking, and terrorism prevention, fight against extremism underline the need for multilateral cooperation aimed at solution of general problems. The novelty of this research lies in the fact that after the dissolution of the Soviet Union, which changed the world political map, the newly formed Central Asian countries gave acquired statehood on the international arena. Namely during this difficult period, the Central Asian countries were forced to choose their own development path. Russia and China, to certain extent, have confirmed their presence in the region by creating the economic and military integration institutions with participation of Central Asian countries. Therefore, the emphasis is placed on the analysis of interaction between China and Russia in the post-Soviet Central Asia, their role in ensuring regional stability and economic growth. The article also examines the importance of studying the role of the United States and the European Union in Central Asia.
The phenomenon of data diplomacy: key terms, research methodology, and current challenges
Authors: Trubachev Vadim
Published: July 2021

The key goal of this research lies in presenting the basic terminology and structure of the phenomenon of data diplomacy, as well as in forming the methodological framework based on the empirical manifestations of data diplomacy in the modern context. The subject of this article is the examination of the three semantic concepts of data diplomacy: “data in diplomacy”, “diplomacy for data”, and “data for diplomacy”, as well as the possibilities of their intersection and interaction for achieving political goals. Using the Russian and international political examples, the author describes the manifestations of these concepts in diplomatic practice. The relevance of data diplomacy emerges due to the ongoing technological changes, which provide new instruments and capabilities for traditional diplomacy. The existing gap between the emergence of new technological instruments, namely those related to big data, and their implementation in the traditional diplomacy of any country, requires deliberate attention and development of methodology that allows determining the key trends in transition from traditional diplomacy to data diplomacy. The main results of the conducted research consists in the formation of a framework for studying data diplomacy, as well as outlining the key legal, ethical, and technological challenges and problems of using big data and their impact upon the role and work of a diplomat, as well as interaction of various actors in the international relations. This brings novelty into the Russian scope of works on digital diplomacy, since the aforementioned framework of data and definition of the key challenges based on it have not been previously reflected in the Russian research.
Certains aspects of using a lies detector for the investigation of crimes
Authors: Krasinskaya Elena
Published: July 2021

The author describes particular theoretical aspects of psychophysiological research with the help of a lie detector, and their role in the investigation of crimes. The research object is the current condition of the theory and practice of using a polygraph. The research subject is the problems of using the results of lie detector testing, their interpretation and role in criminal investigation. The purpose of the research is to study the principles of using, and the options of a lie detector and polygraph examiners, and to define the importance of such a type of research for the investigation of crimes. The research methodology is based on general scientific research methods including analysis and generalization, and specific methods: observation and analysis of psychodiagnostic research. The scientific novelty of the research consists in the comprehensive analysis of the theory and practice of using a polygraph based on the case studies of particular investigations. The author arrives at the conclusion about a further analysis of legal, technical and practical problems of using a polygraph in criminal proceedings, for the purpose of the consideration of the idea about the legislative consolidation of such a research as a proof, which determines the importance of the topic of the research. The practical importance consists in the possibility to use the research results during the evaluation of the polygraph testing and the consideration of the examiner’s report as a proof in the criminal investigation.    
The contribution of Franz Josef Gall to the development of criminal anthropology. Part II. In Search of the physiological origins of compulsive behavior
Authors: Bakharev Dmitry Vadimovich
Published: July 2021

This article is dedicated to the teachings of the Austrian medical scientist and naturalist Franz Josef Gall (1758-1828) on anthropology and human psychology. One of the key theses of Gall’s doctrine consists in the conclusion that the peculiarities of human anthropology and psychology manifest in various forms of social activity. According to Gall, the specificity of physiological processes in human body, peculiarities of personality development, and the intensity of external manifestation of personality traits are substantiated by the peculiarities of formation and subsequent development of separate parts and elements of the human brain. Developmental imbalances or existence of pathologies in the segment of the brain located above the ear canal of the human skull imparts a negative overtone on personality traits. In a worst-case scenario, this may lead to manifestation of such destructive qualities as a pathological lust for violence against animals and people, propensity for arson, and ultimately, homicide. Similar cerebral dysfunctions many have a significant impact upon sexual behavior of a person, and activate destructive qualities. The ideas of F. J. Gall on the influence of developmental imbalances or pathology of separate segments of the human brain upon the occurrence and manifestation of negative personality traits, are still used in modern research in the field of neurocriminology. Namely, the recent findings of American scientists, which are based on the methods of magnetic resonance and positron emission tomography, reveal substantial differences in the structure and functionality of separate segments of the brain of persons who committed murder or convicted of less grave offences.
The Concept of subject in the philosophy of E. Husserl
Authors: Rusakov Sergei Sergeevich
Published: July 2021

This article analyzes the elements of the concept of  subject traced in the philosophy of Edmund Husserl throughout all his works. The author follows the transformation of the views of German philosopher on the idea of subject. As well as their implementation in the context of phenomenological thought. Special attention is given to correlation between the works of Husserl of the early period and the later period.  It is noted that unlike the Cartesian or Kantian model of subjectivity, the egological subject for the first time conceptualizes intersubjectivity as the foundation for the development of the fundamentally new concept of understanding a human as a subject endowed with self-consciousness. The main conclusions consist in the following theses: despite the fact that the key role in the egological concept of subject belongs to the definition of evidence, intentionality, and reduction, the problem of cognition, considered in this article, is developed by Husserl as further complication of the Kantian approach; the egological concept of subject implements the concept of intersubjectivity, which demarcates the ideas of E. Husserl among other approaches towards the concept of subject. understanding the subject. On the one hand, intersubjectivity weakens the position of the idea of absolute autonomy of the subject’ while on the other hand, it is the new mechanism for legitimizing the subjective process of cognition and the truth itself, due to recognition of ego behind the figure of the Other.
In pursuit of identity (relevance of the philosophy of N. Berdyaev)
Authors: Zabneva El'vira Ivanovna
Published: July 2021

This article discusses the topic of identity in the religious philosophy of N. Berdyaev. The author emphasizes the importance of this topic for the philosopher alongside the problematic of freedom and creativity. Emphasis is placed on the existential-religious traditions of Berdyaev’s philosophy, which views a particular individual in his relation to the society and history. According to Berdyaev, an individual is a puzzle not as an organism or social being, but as the identity; the spiritual aspect alone does not depend or determined by the society, which indicates its freedom, although not absolute. The conclusion is made on the relevance of philosophical reflections of N. Berdyaev for the modern state of social development. The author comes into line with the prophetic ideas of the philosopher on the approaching process of dehumanization in spheres of cultural and social life, and namely, dehumanization of moral consciousness. A human fades out as an integral, internally centered, spiritually focused being, who retains cohesion and unity. The author is forced to acknowledge the transformation of moral and ethical values of society, loss of innate thinking, increasing dependence on popular culture and consumer ideology, undermined faith in the future and self-confidence.
Historical development of domestic experience of shared construction of apartment buildings
Authors: Odnopalova Dar'ya Aleksandrovna
Published: July 2021

Currently, the most common way to finance the acquisition of residential real estate is shared construction, which has its drawbacks. This article discusses the domestic and Russian experience of shared construction, and compares the activities and organizations. The object of research is the financing schemes for residential real estate. The subject of the study is the comparative characteristics of financing schemes for multi-apartment residential buildings. The aim of the study is to analyze the experience of shared construction of multi-apartment residential buildings in the USSR and modern Russia. Summarizing the comparative analysis of the features of the organization and activities of domestic and modern experience in shared construction, we can say that these schemes have similarities in attracting public funds for the construction of multi-apartment buildings and that these mechanisms for acquiring housing in the primary market are not safe for their members. Therefore, there is still a need to develop the most effective organization of financing investment and construction projects in the residential real estate market, providing for the interests of the developer, participant in shared construction, the state and the bank.
Cladding panel material as the basis for the typological variety of hinged facade systems
Authors: Aliev Semur Asif ogly
Published: July 2021

  The article discusses the variety of facing panels of hinged façade systems. Typological classification was made on the basis of a variety of materials used for facing panels. The author identifies 6 groups of materials: clay, wood, cement, titanium dioxide, metal, special components. Analysis is conducted on the 18 names of facing panels according to the following characteristics: cladding material, exterior, image application technology, weight in kg / m2, attachment, durability, and manufacturer. The article determines 6 criteria and 2 requirements for ventilated facades. Based on the typology of the material, the author outlines advantages and disadvantages of certain types of facing panels. The article determines the criteria and requirements set for ventilated facades. Leaning on the provided typology of material, the advantages and disadvantages of individual types of facing panels for hinged façade systems are indicated. The relevance of this research is substantiated by the growing need for modern technologies and means to make buildings look architectural and expressive due to an assortment of combinations of facing materials in hinged ventilated systems.  The study reveals a wide variety of characteristics and types of facing panels. The market offer fully reflects the modern production technology capabilities with regards to construction materials. Despite a number of restrictions imposed by the normative acts, facing panels fully meet all the requirements, as the construct of hinged façade panels in general. Thus, is safe to say that facing panels fully satisfy the market demand. Titanium dioxide panels purify the air, which is in line with the current environmental trends contributing to emission reduction and environmental cleanup.
Evolution of regulations for thermal protection of buildings
Authors: Ivanova Lyubov' Vyacheslavovna
Published: July 2021

The article is devoted to the study of regulatory documents in the field of thermal engineering in construction and the development of regulations for thermal protection of buildings. The object of the research is the standard documentation in the field of thermal engineering in construction. A retrospective analysis of the norms and requirements for thermal protection of buildings was carried out by identifying qualitative changes in the content of standard documentation. Building codes and regulations, Code specification, Federal laws and Government decrees have been adopted as such regulatory documents for this study. The documents that influenced these changes are considered. The normative requirements of the past years in the field of building heat engineering have been systematized. Six stages of the formation of norms for the thermal protection of buildings are determined, based on changes in the formulas for determining the resistance to heat transfer of enclosing structures and the introduction of the characteristic of the degree-day of the heating period, depending on the climatic features of the region. Trends in the development of standards for thermal protection of buildings have been determined. The main goal is to reduce the specific characteristic of heat energy consumption for heating and ventilation, which requires a change in the requirements for thermal protection, in particular, an increase in the required resistance to heat transfer, which can contribute to updating the existing set of rules for thermal protection of buildings.
Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis
Authors: Papareddy Ranjith K , Páldi Katalin , Smolka Anna D , Hüther Patrick , Becker Claude , Nodine Michael D
Published: July 2021

DNA methylation has evolved to silence mutagenic transposable elements (TEs) while typically avoiding the targeting of endogenous genes. Mechanisms that prevent DNA methyltransferases from ectopically methylating genes are expected to be of prime importance during periods of dynamic cell cycle activities including plant embryogenesis. However, virtually nothing is known regarding how DNA methyltransferase activities are precisely regulated during embryogenesis to prevent the induction of potentially deleterious and mitotically stable genic epimutations. Here, we report that microRNA-mediated repression of CHROMOMETHYLASE 3 (CMT3) and the chromatin features that CMT3 prefers help prevent ectopic methylation of thousands of genes during embryogenesis that can persist for weeks afterwards. Our results are also consistent with CMT3-induced ectopic methylation of promoters or bodies of genes undergoing transcriptional activation reducing their expression. Therefore, the repression of CMT3 prevents epigenetic collateral damage on endogenous genes. We also provide a model that may help reconcile conflicting viewpoints regarding the functions of gene-body methylation that occurs in nearly all flowering plants.
Sexual Terrorism and Social Stigma: How Stigma Influences the Pathway to Justice for Survivors of Boko Haram, and Potential Ways Forward
Authors: van de Klundert Manouk AW
Published: July 2021

Boko Haram has victimised numerous women and girls using tactics of sexual terrorism. As criminal justice for this crime is rarely obtained, this article seeks to find ways to bring social justice to its survivors. However, the stigmatisation of the survivors, which is signalled to
frequently occur, hampers this process greatly. As survivors of sexual terrorism suffer from stigma, they are being denied social justice, since their position in society is compromised or their suffering is even being denied. This article comprises a literature review that aims to combine
published work concerning sexual terrorism, social justice and stigma in an explorative, yet systematic way to identify underlying mechanisms and classify potential ways forward. It was found that stigmatisation, both from wider society as survivors' close connections can have a great psychological
impact, on top of the frequently severe physical, psychological, and socio-economic consequences that sexual terrorism already brings forward. Six kinds of interventions were found to reduce the survivor's suffering and stigmatisation, thereby enlarging their social justice.
Proton Pump Inhibitors and Gastric Cancer
Authors: Kang Seungkyung , Cho Soo-Jeong
Published: July 2021

Concerns have been raised regarding the long-term use of proton pump inhibitors (PPIs) as an important risk factor for gastric cancer in clinical practice. PPIs can cause hypergastrinemia at clinical doses, and hypergastrinemia has been reported to induce malignant neoplasms in the stomach in previous animal studies. In humans, the proliferation of enterochromaffin-like (ECL) cells induced by hypergastrinemia is suspected as a potential mechanism of gastric cancer. Meanwhile, persistent Helicobacter pylori (H. pylori) infection causes gastric atrophic change, which itself is a major cause of gastric cancer, and it can further increase the risk of gastric cancer by strengthening corpus atrophy through interaction with PPIs. Recent epidemiologic studies have reported an important link between long-term PPI intake and gastric cancer risk even after successful eradication of H. pylori. However, due to the methodological limitations of observational clinical studies, the causal relationship is still not clear, and a recent big data-based study reported that long-term PPI use was not related to gastric cancer incidence. Taken together, despite the potential detrimental effects of PPIs, it is currently difficult to draw a definite conclusion about its association with gastric cancer. To minimize the possibility of gastric cancer in H. pylori-infected patients or precancerous lesions in long-term PPI users, long-term PPI administration should be limited to the minimum effective dose, and antibacterial treatment for H. pylori should be considered.
How fish traits and functional diversity respond to environmental changes and species invasion in the largest river in Southeastern China
Authors: Lin Li , Deng Weide , Huang Xiaoxia , Liu Yang , Huang Liangliang , Kang Bin
Published: July 2021

Background

Freshwater fish populations are facing multiple stressors, including climate change, species invasion, and anthropogenic interference. Temporal studies of fish functional diversity and community assembly rules based on trait-environment relationships provide insights into fish community structure in riverine ecosystems.

Methods

Fish samples were collected in 2015 in the Min River, the largest freshwater riverine system in Southeastern China. Fish functional diversity was compared with the background investigation in 1979. Changes in functional richness, functional evenness, functional divergence, and functional beta diversity were analyzed. Relationships between functional diversity and environmental factors were modeled by random forest regression. Correlations between fish functional traits and environmental factors were detected by fourth-corner combined with RLQ analysis.

Results

Functional richness was significantly reduced in 2015 compared with 1979. Functional beta diversity in 2015 was significantly higher than that in 1979, with functional nestedness being the driving component. Reduction of functional richness and domination of functional nestedness is associated with species loss. Trait convergence was the dominant mechanism driving the temporal changes of functional diversity. Precipitation, temperature, species invasion, and human population were the most significant factors driving fish functional diversity. Higher precipitation, higher temperature, and presence of invasive species were significantly associated with higher swimming factor and higher relative eye diameter, while the opposite environmental conditions were significantly associated with higher pectoral fin length and eurytopic water flow preference.

Conclusions

Environmental filtering is the dominant temporal assembly mechanism shaping fish community structure. This work contributes to the understanding of temporal freshwater fish community assembly and the associations between fish functional structure and local environmental conditions, which will be informative for future freshwater fish conservation.
Relationship between Corporate Social Responsibility Performance and Systematic Risk—A Case Study of A-share Listed Chinese Companies
Authors: Hsiao Chih-Yi , Lin Xue , Cen Ke-Ke , Zheng Wan-Ping
Published: July 2021

Taking the A-share listed companies in the 2018-2019 Environment, Social and Governance (ESG) rating by the China Alliance of Social Value Investment (CASVI) as samples, we analyze the impact of Corporate Social Responsibility (CSR) performance on the current systematic risk and its deferred effect. By using quantile regression and the ordinary least squares (OLS) for cross-comparison, we find that 1) for high-risk companies, the current performance of CSR can help reduce systematic risks, and 2) for low-risk companies, the more progress they make in CSR performance but do not disclose social responsibility information according to the global reporting initiative (GRI) guideline, the more systematic risks they will encounter; if they proactively disclose such reports, however, they may reduce systematic risks. Based on our findings, we propose the following measures: 1) the government should properly guide economic development; 2) companies should actively disclose CSR reports so as to achieve a win-win result for both the companies and their stakeholders; 3) investors should consult social responsibility information to make rigorous investment plans, before making investment decisions.
Marketing Strategy of HDL 293 Cilaki Bandung Seafood Restaurant (West Java) in the Midst of COVID-19 Pandemic
Authors: Amini Ghaida Yasmin , Nurhayati Atikah , Rizal Achmad , Handaka Asep Agus
Published: July 2021

This research was held at HDL 293 seafood restaurant located on Cilaki street, Bandung, West Java. The implementation started on April 2020 until May 2021. This research aims to analyze internal environmental conditions including strengths and weaknesses, while external environmental conditions including opportunities and threats faced, then formulate and analyze marketing strategy during the COVID-19 pandemic. The method used is a case study using primary and secondary data. The sampling method used was accidental sampling and data processing used SPSS 25, Ms. Excel through SWOT analysis. Based on research, the best strategy for development of HDL 293 Cilaki Bandung seafood restaurant using SWOT analysis is in Quadrant I by implementing the SO (Strength and Opportunity) strategy or supporting an aggressive growth policy (growth oriented strategy). Where the coordinates are 0.38 ; 0.05 means taking advantage of strengths to seize opportunities that exist.
Levels of Plasma 8-Hydroxy-2'-Deoxyguanosine—A Marker of Oxidative DNA Damage—Are Not Associated with Primary Angle-closure Glaucoma
Authors: Kondkar Altaf A.
Published: July 2021

Aim: The study aimed to estimate plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, a marker of oxidative deoxyribonucleic acid (DNA) damage, and evaluate their potential association with primary angle-closure glaucoma (PACG) and related clinical markers.

Study Design: This is retrospective case-control study.

Place and Duration: The study was performed on samples recruited from King Abdulaziz University Hospital, Riyadh, Saudi Arabia between August 2018 through September 2019 in the participants of Saudi origin.

Methodology: Plasma 8-OHdG levels were measured in duplicates using automated ELISA analyzer in 43 PACG patients and 45 non-glaucomatous controls.

Results: The mean levels of 8-OHdG were 13.59 ng/mL [±4.50] in PACG patients compared to 16.95 ng/mL [±10.66] in controls. The differences did not achieve statistical significance (P = 0.06). Similarly, no significant differences (P = 0.42) were observed in the median levels of 8-OHdG between PACG and controls. Furthermore, except for sex, where males exhibited a significant negative correlation (R = -0.35, P = 0.02), there was no significant correlation between 8-OHdG levels and age (P = 0.85), intraocular pressure (P = 0.58), cup/disc ratio (P = 0.39) and number of antiglaucoma medications (P = 0.41) in the PACG group. Regression analysis showed no significant influence of age, sex, and 8-OHdG levels on PACG outcome. Besides, the area under the receiver operating characteristic curve was 0.55 and non-significant (P = 0.42).

Conclusion: There is no association between plasma levels of 8-OHdG and PACG or its specific clinical markers. Further studies in a much larger cohort are needed to validate these findings.
Impact of 6 Weeks Pilates Training on Menopause Specific Symptoms and Quality of Life in Menopausal Women: A Case Report
Authors: Bais Anjali , Mishra Simran A. , Darda Palak P. , Phansopkar Pratik
Published: July 2021

Introduction: The concept of menopause is a complete cessation of ovarian function. Most common symptom of menopause include muscle and joint ache, poor memory, lower back pain and trouble sleeping. The vasomotor and emotional domains reported less often compared with the physical and psychological domains. Such adverse changes in physical and mental health may have a negative impact on Quality of Life (QOL). Pilates is a mind body exercise focusing on muscle strength, core stability, endurance, muscle control, posture, and respiration which seems to improve both the physical and psychological components in women during menopause. The given study helps to provide the effect of 6 weeks Pilates training protocol on menopausal women’s presenting complaints as well as on her QOL.
Complaints and clinical finding: Patient’s main concern were low back ache without any cause night sweats, fatigue, disturbed sleep wake cycle which lead to difficulties in performing activities of daily living which hampered the QOL of the patient. Physical findings revealed decrement in lower back and lower limb muscle strength along with some tightness. Scales helped to reveal that patient is having fatigue and tiredness and mat-exercise treatment protocol were formed.
Therapeutic Intervention: 6 weeks Pilates training.
Conclusion: As there are minimal to no evidence present in reference to this study, it helps us to provide new and proper treatment protocol and it is helpful to know the effect of the same. It showed significant improvement in the muscular strength as well as reduction in stress level and helped in enhancing the QOL of the patient.
Correlation of p53 Immunoexpression with Depth of Tumor in Microinvasive Oral Squamous Cell Carcinoma
Authors: Sonone Archana , Patil Swati , Hande Alka , Gawande Madhuri
Published: July 2021

Introduction: “Oral squamous cell carcinoma (OSCC)” is a major health issue in India, the incidence of OSCC is 3-7 times more in developing countries than developed countries. OSCC is the ‘3rd most common cancer’ in India followed by “cervical and breast cancer”. One side  of OSCC that  has not much explore is the ‘microinvasive squamous cell carcinoma’ which is an early stage neoplasm  without infiltration in the deeper tissues. There is no particular definition of “microinvasive oral squamous cell carcinoma (MIOSCC)” There are no specific guideline are present to categories the “microinvasive squamous cell carcinoma (MIOSCC)”. Most of the time the infiltrating neoplastic cells are masked under the background of the inflammatory cell infiltrate present connective tissue stroma. So this study is humble attempt to recognized and measured depth of invasion of infiltrative neoplastic cells to categories MIOSCC and to find better management protocol for it

Aim: This study aims to: Measure p53 immunoexpression  in “microinvasive oral squamous cell carcinoma, evaluate the depth of invasion in MIOSCC  in H & E stained section, and correlate the  p53 immunoexpression with  the depth of tumor in it.

Methodology: The  25 cases of  “microinvasive oral squamous cell carcinoma” will be selected  and 10 cases of “normal oral mucosa (NOM)” will be   obtained from “gingiva and vestibular mucosa” as controls  after extraction of impacted teeth. “The depth of tumor”  will  be measured from the “basement membrane or in areas of basement membrane loss, from an imaginary line reconstructing the basement membrane from the adjacent epithelium to the deepest point of invasion in connective tissue” by  Leica DMLB2 research microscope with Leica Q-win standard software (Switzerland).

Results: The results  show that   the depth of invasion in MIOSCC, will be  categorized the lesion and give the better guidelines for histological grading and treatment protocol for MIOSCC

Conclusion: There are no definite guidelines for histological grading and final treatment protocol for MIOSCC. The assessments of depth of tumor through p53 immunoexpression may be one of the criteria for grading in MIOSCC. Thus the correlation of p53 immunoexpression with the depth of tumor in MIOSCC helps to determine the treatment modalities of MIOSCC.
Telmisartan Induced Myotoxicity: A Case-Report
Authors: Hadia Rajesh , Bhavsar Krishna , Patel Riddhi , Shivadas Vidhya
Published: July 2021

The precise incidence of drug-induced myopathy is still not known, only few reports with the use of Telmisartan. There are likely around 150 agents that are associated to cause myotoxicity like statins, corticosteroids, anti-retroviral, and immunosuppressants. Therefore, as recommended by the guidelines, therapeutic drug monitoring of Telmisartan is required after the initiation of the therapy. However, the rise in serum creatinine up to 20-30% is accepted. But if serum creatinine level increases >30% then withdrawal of the therapy is recommended.

Suspicious with the previous therapy of Tab. Telmisartan as no other pathology could be detected. A causality analysis was done using the Naranjo’s algorithm and WHO-UMC Scale and the present ADR was found to be ‘Probable’ with Telmisartan. Tab. Telmisartan was withdrawn completely and was switched by another Antihypertensive -Tab. Enalapril (5mg). Gradually, the condition of the patient showed improvement in terms of both- the clinical symptoms and laboratory abnormalities. However, re-challenge of the drug was not performed in order to avoid further toxicity. After 15 days, the patient had visited Medicine Outpatient Department (OPD) again the creatinine and uric acid levels where checked which were normal and further advised to follow up every month. To be conclude, adverse drug reaction of myotoxicity associated with telmisartan is rare but quite significant. So, close monitoring is necessary to ensure safety of drug therapy especially in long term use.
A Physiotherapeutic Approach Along with Bronchodilators to Control Bronchial Asthma in a 35 Year Old Adult: A Case Report
Authors: Thombare Nupur , Yadav Madhumita , Phansopkar Pratik
Published: July 2021

Background: Bronchial asthma is a common disease characterized by the generalized narrowing of intrapulmonary airways accompanied by breathlessness and wheezing, which differs in severity spontaneously or as a result of treatment. Asthma is caused by bronchial wall inflammation and constriction due to the hyper-reactivity of their smooth muscle, resulting in a series of spasmodic wheezing attacks and shortness of breath (SOB).
Case description: The patient was a 35 year old female presented with a complaint of dry cough with mucoid expectoration and chest pain since 3 weeks. The cough was progressive and aggravating while walking or while doing any sort of activity and it use to relieve at rest. She also complained of Modified Medical Research Council (MMRC) grade 2 breathlessness along with palpitation while doing household work. She had chest pain while coughing on left side over the 2nd intercostal space which was gradually progressive and 7/10 on VAS. She also had low grade fever, cold with chills and night sweats. The patient had a history of seasonal variation, dust allergies and biomass exposure. She was given medications but was not relieved so she was referred for physiotherapy. Physiotherapy treatment was started. Patients sleep was disturbed. The patient had no past history. Family history is not present.
Diagnosis: The patient was diagnosed with bronchial asthma.
Outcomes & conclusion: This case study showed that breathing exercise, postural drainage and proper relaxation of the patient may reduce the symptoms associated with bronchial asthma also the peak flow values may increase with breathing retraining. Pain reduces with reduction in cough and episodes of dyspnoea. Also educating the patient about prevention of asthmatic episodes help the patient in many ways. Along with bronchodilators physiotherapy plays an integral part in treating the patient with bronchial asthma.
COVID-19, a Pandemic Situation: Symptoms and its Prevention Scenario
Authors: Hardaswani Daksh
Published: July 2021

The corona virus COVID-19 is the pandemic due to global health crisis among the world and greatest challenge that we have faced in 21ST century. The novel corona virus disease COVID-19 has become the 5th pandemic which is reported in Wuhan, China and gradually spread into worldwide. This virus is a spillover of an animal virus and then also adapted the ability of transferring human to human. This virus is highly contagious due to rapid spread and constantly evolves in the human population. This virus has spread to every continent of the world and the death ratio is staggering. The COVID-19 pandemic is a lot more than just a health calamity, but it is also socio-economic because people are losing jobs and income. The COVID-19 disease affects physical and mental health due to isolation. Moreover, more and more countries are affecting the cases of COVID-19 which are rising very rapidly day by day. Therefore, every country needs to several actions which accelerates their safety health, balance between the protection of health, prevent economic and social disruption due to this pandemic. In the spirit of the solidarity, we all need to be contributing our self to protect this situation. However, every country is equally responsible for determining the measures to prevent or decrease the viral transmission. Government authorizes also trying to act for reduce disease’s trajectory and they focus on develop the vaccination and therapeutic drugs.
Covid - 19: Government Intervention and Post Covid Complications in India
Authors: Tiwari Akhilesh , Sandalwala Jainab , Joshi Megha , Gupta Anil Kumar
Published: July 2021

Most discussing topic in the year 2020 is nCovid-19, popularly known as Covid-19 in which most anticipated debates are going on for concluding the justification of lockdown. Present work reveals that India where large population lives in very dense localities are still struggling for improving its healthcare facilities. From very beginning government of India has taken many important steps to protect the country from this pandemic. The Government has taken the decision of lock down and face criticism for imposing lock down. But now we can understand that at very initial stage where the modern science and technology failed to explain all aspects of this pandemic, in that situation the lockdown was a good decision, It provided sufficient time for government and healthcare departments to be ready to deal with this pandemic. This paper is also explain the post Covid-19 complications.
Ancient Overview of Modern Genetics as Per Ayurveda: A Review
Authors: Thankachan Shyny , Kulkarni Bhagavan G. , Dayana H.
Published: July 2021

The human genome studies reveal that most of the diseases have a genetic component. Genetic mutation occurs either randomly or due to an environmental factor. Genetic disorders may or may not be hereditary. WHO data illustrate that the congenital anomalies are the reason for 17%–43% of infant mortality. If parent’s genetic configuration is vulnerable to some diseases, their children and grandchildren are more susceptible to such illness. This suggests that their genes or chromosomes possess aberrant changes and are carried over into next generation and results in congenital or hereditary diseases. Ancient ayurvedic acharyas had the idea that the genetic materials are transmitted from generation to generation. The expression of these can be understood with regard to prakriti. An individual’s unique physical characteristics and psychic behaviors (phenotype) depends on the prakriti. Genetics emerged in mid to late 19th Century. But centuries before itself, ancient Ayurvedic literature documented the union of sukra and shonita, concept of beeja, beejabhaga and beejabhagavayava, inheritance, congenital anomalies, and genetic disorders. Ayurveda also gave importance to personalized or individualized concepts of understanding and treating diseases. Ayurvedic concepts like garbhasambhavasamagri (factors necessary for formation of garbha) and garbhotpadaka bhava (six procreating factors), dinacharya, ritucharya, sadvritha, dharaneeya, adharaneeyavega, ritumaticharya, & garbhinicharya assures the regulation of gene sequencing and gene expression and thus can-do wonders to the challenging issues.
Visualization of Collagen–Mineral Arrangement Using Atom Probe Tomography
Authors: Lee Bryan E. J. , Langelier Brian , Grandfield Kathryn
Published: July 2021

Bone is a functional material comprised of mainly two phases: an organic collagenous phase and an inorganic mineral phase. Collagen–mineral arrangement has implications for bone function, aging, and disease. However, theories on collagen‐mineral arrangement have been confined to studies with low spatial and/or compositional resolution resulting in an extensive debate over the location of mineral with respect to collagen. Herein, a strategy is developed to extract a single mineralized collagen fibril from bone and analyze its composition and structure atom‐by‐atom with 3D sub‐nanometer accuracy and compositional clarity using atom probe tomography (APT). It is shown for the first time a method to probe fibril‐level mineralization and collagen–mineral arrangement from an in vivo system with both the spatial and compositional precision required to comment on nanoscale collagen–mineral arrangement. APT of leporine bone shows distinct and helical collagen fibrils with mineralized deposits both encapsulating and incorporated into the collagenous structures. This study demonstrates a novel fibril‐level detection method that can be used to probe the composition of bone and contribute new insights to the structure and organization of mineralized materials such as bones and teeth.
High‐Yield Production, Characterization, and Functionalization of Recombinant Magnetosomes in the Synthetic Bacterium Rhodospirillum rubrum “magneticum”
Authors: Mickoleit Frank , Rosenfeldt Sabine , Toro‐Nahuelpan Mauricio , Schaffer Miroslava , Schenk Anna S. , Plitzko Jürgen M. , Schüler Dirk
Published: July 2021

Recently, the photosynthetic Rhodospirillum rubrum has been endowed with the ability of magnetosome biosynthesis by transfer and expression of biosynthetic gene clusters from the magnetotactic bacterium Magnetospirillum gryphiswaldense. However, the growth conditions for efficient magnetite biomineralization in the synthetic R. rubrum “magneticum”, as well as the particles themselves (i.e., structure and composition), have so far not been fully characterized. In this study, different cultivation strategies, particularly the influence of temperature and light intensity, are systematically investigated to achieve optimal magnetosome biosynthesis. Reduced temperatures ≤16 °C and gradual increase in light intensities favor magnetite biomineralization at high rates, suggesting that magnetosome formation might utilize cellular processes, cofactors, and/or pathways that are linked to photosynthetic growth. Magnetosome yields of up to 13.6 mg magnetite per liter cell culture are obtained upon photoheterotrophic large‐scale cultivation. Furthermore, it is shown that even more complex, i.e., oligomeric, catalytically active functional moieties like enzyme proteins can be efficiently expressed on the magnetosome surface, thereby enabling the in vivo functionalization by genetic engineering. In summary, it is demonstrated that the synthetic R. rubrum “magneticum” is a suitable host for high‐yield magnetosome biosynthesis and the sustainable production of genetically engineered, bioconjugated magnetosomes.
From main axes control to flexible body control of large telescope structures
Authors: Kärcher Hans J.
Published: July 2021

Astronomers have to point their telescopes with extreme high precision to their targets on the sky. The early craftsmen, which built their telescope mounts, were masters in mechanics and developed sophisticated axis mechanisms based on clockwork motors for the hour angle. The situation changed with the growth of the size of the optical telescopes, the upcoming of large radio telescopes, the related transition to elevation over azimuth mounts and the introduction of electrical main axes drives. The new telescopes were equipped with gears of high transmission ratios, and the dynamics of the motor control was limited by mechanical resonances between the rotors of the motors and the mass of the telescope structure. Early layout tools for the controllers were lumped mass models for the telescope structure including gear stiffnesses and inertias of rotors and brakes, with the free rotor and locked rotor frequencies as critical characteristics influencing the servo loop performance. Nowadays, static and dynamic analysis is performed with the help of finite element models, and the axes controllers are optimized with end‐to‐end models. The emergence of large radio telescopes initiated the development of additional compensation methods for environmental influences as temperature and wind on the shape of the reflectors and their pointing to the sky. Additional active elements on the telescope as surface actuators and subreflector positioners, and additional state sensors on the structure allow the identification and compensation of structural deformations. The method is called flexible body control (FBC). The increasing size of the optical telescopes initiated the development of new mirror technologies as thin meniscus or segmented mirrors in sizes not feasible with the passive supported thick meniscus mirrors. These mirrors need active elements as shape actuators, segment positioners, and wavefront and edge sensors. The method is called active optics (AcO). Astronomical observations in the visible are disturbed by atmospheric blur, and the operability is depending of the active compensation of that blur, based on a fast wavefront sensor analyzing an artificial star and an additional fast wavefront corrector. The method is called adaptive optics (AdO). The following text gives an overview on the historic development of telescope control systems from the viewpoint of the telescope mount and its axes control systems, finally culminating in FBC applications. Actual examples are the large millimeter telescope LMT/GTM in Mexico, the advanced technology solar telescope DKIST in Hawaii, and the airborne telescope of SOFIA, the Stratospheric Observatory for Infrared Astronomy with its base in Palmdale, California.
Stable Light‐Emitting Electrochemical Cells Using Hyperbranched Polymer Electrolyte
Authors: Mardegan Lorenzo , Dreessen Chris , Sessolo Michele , Tordera Daniel , Bolink Henk J.
Published: July 2021

The choice of an adequate electrolyte is a fundamental aspect in polymer light‐emitting electrochemical cells (PLECs) as it provides the in situ electrochemical doping and influences the performance of these devices. In this study, a hyperbranched polymer (Hybrane DEO750 8500) blended with a Li salt is used as a novel electrolyte in state‐of‐the‐art Super Yellow (a polyphenylenevinylene) based LECs. Due to the desirable properties of the hyperbranched polymer and the homogeneous and smooth films that it forms with the emitting polymer, PLEC with excellent electroluminescent properties are obtained using a pulsed current bias scheme. The devices are very stable, with lifetimes in excess of 2000 h with initial luminance values above 450 cd m−2, a peak efficiency of 12.6 lm W−1, and sub‐minute turn‐on times. The stability of the devices is also studied by measuring the photoluminescence (PL) of the semiconductor during electroluminescent operation. The findings suggest that it is possible to observe the quenching of the PL in vertically stacked devices due to the advancement of the doped fronts in the film and an immediate PL recovery when the bias is removed.