bluuebunny/crossref_metadata_2025 huggingface dataset:
Adapting the Mullen Scales of Early Learning for a Standardized Measure of Development in Children With Rett Syndrome
Authors: Clarkson Tessa , LeBlanc Jocelyn , DeGregorio Geneva , Vogel-Farley Vanessa , Barnes Katherine , Kaufmann Walter E. , Nelson Charles A.
Published: December 2017

Rett Syndrome (RTT) is characterized by severe impairment in fine motor (FM) and expressive language (EL) function, making accurate evaluations of development difficult with standardized assessm ents. In this study, the administration and scoring of the Mullen Scales of Early Learning (MSEL) were adapted to eliminate the confounding effects of FM and EL impairments in assessing development. Forty-seven girls with RTT were assessed with the Adapted-MSEL (MSEL-A), a subset (n = 30) was also assessed using the Vineland Adaptive Behavior Scales-Second Edition (Vineland-II) and a further subset (n = 17) was assessed using an eye-tracking version of the MSEL (MSEL-ET). Participants performed better on the visual reception (VR) and receptive language (RL) domains compared to the FM and EL domains on the MSEL-A. Individual performance on each domain was independent of other domains. Corresponding MSEL-A and Vineland-II domains were significantly correlated. The MSEL-ET was as accurate as the MSEL-A in assessing VR and RL, yet took a 44% less time. Results suggested that the MSEL-A and the MSEL-ET could be viable measures for accurately assessing developmental domains in children with RTT.
Development of the Supported Decision Making Inventory System
Authors: Shogren Karrie A. , Wehmeyer Michael L. , Uyanik Hatice , Heidrich Megan
Published: December 2017

Supported decision making has received increased attention as an alternative to guardianship and a means to enable people with intellectual and developmental disabilities to exercise their right to legal capacity. Assessments are needed that can used by people with disabilities and their systems of supports to identify and plan for needed supports to enable decision making. This article describes the steps taken to develop such an assessment tool, the Supported Decision Making Inventory System (SDMIS), and initial feedback received from self-advocates with intellectual disability. The three sections of the SDMIS (Supported Decision Making Personal Factors Inventory, Supported Decision Making Environmental Demands Inventory, and Decision Making Autonomy Inventory) are described and implications for future research, policy, and practice are discussed.
Una revisión del mosaico dionisíaco de la villa romana de Albaladejo (Ciudad Real)
Authors: García Bueno María Del Carmen
Published: December 2017

A lo largo de las siguientes páginas intentamos profundizar en la lectura del único mosaico figurativo de esta villa que ha llegado hasta nuestros días. Además, queremos dar a conocer algunas noticias y material gráfico inéditos.
La alimentación en al-Andalus a partir del registro arqueofaunístico. Estado de la cuestión
Authors: Vaquerizo Gil Desiderio
Published: December 2017

Al Andalus fue un espacio plural, dinámico y variable en el tiempo, que bebió de influencias culturales muy diversas. Todo ello le dio una idiosincrasia mestiza y claramente mediterránea que sólo consiguieron matizar la religión y sus rigurosas prescripciones, también en el campo de la alimentación. Aun así, y con sólo ligeros matices que evolucionan, cambian o se enriquecen a lo largo de los siglos conforme evoluciona también el propio al Andalus, los andalusíes practicaron un modo de comer sano y socializador, nutrido de alimentos que combinaron de forma hábil y sabia incluso en sus expresiones más pobres y frugales -dirigidos de alguna manera por sus sabios y dietistas, herederos militantes de los legados grecorromano y oriental-, pero también de manera intuitiva y espontánea. Tales prácticas se vieron favorecidas por un nuevo sistema de explotación de las tierras, basado fundamentalmente en la irrigación, la introducción de nuevas especies vegetales y una intensificación racional de las cosechas que les permitieron disponer de productos frescos todo el año, protagonistas sin saberlo de lo que muchos autores han dado en llamar la revolución verde. De todo ello dan buena cuenta las fuentes escritas, pero también la arqueología, en particular el registro faunístico; de ahí la necesidad de cruzarlos, en aras de contrastar ambos universos.
Salient accounting value drivers and equity re-turns : Evidence from US industries
Authors: Camara Omar
Published: December 2017

Past literatures suggest the presence of ubiquitous disquiet among corporate financial managers, financial analysts and portfolio managers that changes in certain accounting variable's results in changes in stock prices, irrespective of whether future cash flow's subsume these changes in salient accounting variables. Using an empirical rational inquiry, this paper attempts to test whether there is any relationship between salient accounting variables and equity returns for five major US industries (Manufacturing, Services, Wholesale, Constructions and Retail) from the period 1996 to 2015, and as a result, may contribute to accretion or loss in stockholdersâ€™ wealth. To account for divergent industry-specific revenue generating process and the existing fluidity in industry-specific application of accounting standards, this study thus disaggregates sample data by industry. The industry approach implies that the effect of salient accounting variables on equity prices may be described as a conflation of industry-specific characteristics and capital market synergies. Consistent with this notion, this study finds that salient accounting variables which are used to measure operating performance, growth opportunities, investment management and profitability have the significant impact on equity returns. However, and most importantly, the study finds that the impact of the salient accounting variables varies from one industry to another. As such, this study is particularly useful for equity market participants in the identification of industry related, market-relevant accounting variables, which may be used to guide future financial policies.
Investigation of the case method in accounting education
Muhasebe eğitiminde vak’a yönteminin irdelenmesi
Authors: Güney Aysel
Published: December 2017

Training is the development of human skills and behaviors in a certain process. Because of this reason, training is necessary to be carried out by specialists. A quality education improves the existing system, reduces costs and increases revenues (Korkmaz, 1997). Managers and faculty members of specifically the higher education institutions must meet the constantly changing needs and requests of the individuals or institutions in the customer situation with the highest quality products. The accounting courses are offered by educational institutions should be organized as a whole and conveyed to the students within the system. Case method which is one of the methods that will enable the student to develop his point of view during this conveyance. Therefore, this study aims  to focus on the place and importance of the case method in accounting education.Extended English abstract is in the end of Full Text PDF (TURKISH) file.Özetİnsan beceri ve davranışlarının belli bir süreç içinde geliştirilmesi eğitim olarak tanımlanabilir. Eğitimin uzmanlarca yapılması gereklidir. Kaliteli bir eğitim sonucunda mevcut sistem gelişir, maliyetler düşer ve gelirler artar. (Korkmaz, 1997). Özellikle üniversite kurumları içinde bulunan ve görev yapan yöneticiler ve öğretim üyeleri, muhasebe bilgisini ve muhasebe elemanının talep eden kişi veya birimlerin sürekli değişen ihtiyaç ve isteklerini iyi yetişmiş bireylerle karşılamak durumundadırlar.  Bu yüzden özellikle yükseköğretim kurumlarında verilen muhasebe derslerinin bir bütün olarak düzenlenmesi ve bir sistem anlayışı içerisinde öğrencilere aktarılması zorunludur. Bu aktarım sırasında öğrencinin bakış açısını gelişmesini sağlayacak yöntemlerden birisi vak’ a yöntemidir. Bu çalışmada muhasebe eğitiminde vak’a yönteminin yeri ve önemi üzerinde durulacaktır.
Micro sociological syndromes
Authors: Aydoğmuş Ördem Özlem
Published: December 2017

With the emergence of postmodernist and poststructuralist theories, studies on micro sociology have begun to gain importance in recent years. Contrary to research on general societal structures, micro sociological studies attempt to understand how individuals or small groups are affected by micro-environment, general macro-sociological structures and socialization processes such as family and relatives, and these processes. This study examined the micro-sociological processes in which a participant lived in 16 years. The research method is composed of longitudinal idiographic technique. The data were obtained by log keeping and interview methods. The study shows that the participant experienced severe syndrome at the micro sociological level. The family showed that the participant did not agree with the values of friends, relatives and general social structure, and that they were in conflict. The findings were interpreted within the framework of the concepts of social dialogue and ambivalence. These two concepts were analyzed on the basis of postmodernist and poststructuralist theories and the data of participants were analyzed.
Proklamasi 17 Agustus 1945: Revolusi Politik Bangsa Indonesia
Authors: Rinardi Haryono
Published: December 2017

Artikel sederhana ini membahas persoalan arti penting Proklamasi Kemerdekaan 17 Agustus 1945 bagi bangsa Indonesia, terutama berdasar pada keabsahannya dari segi hukum. Untuk menjawab persoalan hukum yang menyertai peristiwa Proklamasi Kemerdekaan RI tersebut, maka perlu diungkap terlebih dahulu latar belakang peristiwa sehingga dapat dijadikan landasan untuk menjawab pertanyaan tersebut. Kajian ini menekankan pada penggunaan literatur sebagai metode utama untuk menelaah persoalan. Oleh karena itu, berdasar pada penelaahan tersebut, artikel ini merumuskan bahwa gagasan kemerdekaan Indonesia secara legal formal diperoleh melalui proses perjuangan yang panjang, bukan merupakan ‘hadiah’ atas praktik kolonialisasi yang berlangsung saat itu.
Identity, Positioning, Brand Image and Brand Equity Comparison.
Authors: Chaves Eduardo de Paula e Silva
Published: December 2017

The management of marketing has as presupposition the understanding of the relations between market and consumption, as well as, the concepts related to the maximization of the results of the company. In this way, an article was elaborated in search of the understanding of the existing relations between brand identity, positioning, brand image and brand equity. In this context, qualitative-quantitative research was sought to describe the existing relationships between concepts, as well as the conceptual and managerial gaps arising from their management. As a result of this work we have the analysis of the conceptual and operational gaps of these concepts.
Organizational creativity in innovation – a multicriteria decision analysis
Authors: Martins Fellipe Silva , Santos Eduardo Biagi Almeida , Vils Leonardo
Published: December 2017

Creativity is essential for the emergence of innovation within organizations, both necessary for organizational survival. Several models have been proposed for organizational creativity, each containing different constructs. This research aims to verify the standardization of constructs in the literature and to verify the possible existence of two dimensions not previously explored: hierarchy between constructs (global importance) and weight of constructs (relative importance) of organizational creativity that lead to innovation. We employed Multicriteria Decision Analysis with the PAPRIKA method, which combines the advantages of numerical and verbal decision making. The creativity constructs were elicited from a detailed review of the literature from Scopus and Web of Science databases. The results contribute to the expansion of the current theory of creativity, with the application of a new method to the object and management practices.
Comparing the environmental impacts of ethyl biodiesel production from soybean oil and beef tallow through lca for brazilian conditions
Authors: Esteves Rafael Alves , Pereira Roberto Guimarães
Published: December 2017

The present paper sought compare the environmental impacts throughout the life cycle of biodiesel production obtained from the two raw materials most used in Brazil (soybean oil and beef tallow) through the process ethyl transesterification in an alkaline medium. The reference flow adopted for the work was the generation of power supplied 1GJ from the produced biodiesel. The data used in the inventory life cycle were calculated based on similar scientific papers. The method of assessment of environmental impacts chosen was the CML 2001 modified. Altogether, it were analyzed nine categories of environmental impacts for both processes (abiotic depletion (kg Sb eq), land use (m2a), global warming (kg CO2 eq), ozone layer depletion (kg CFC-11 eq), human toxicity (kg 1,4-DB eq), freshwater ecotoxicity (kg 1,4-DB eq), terrestrial ecotoxicity (kg 1,4-DB eq), acidification (kg SO2 eq) and eutrophication (kg PO43- eq)). The results of evaluation of environmental impacts show that the biodiesel production process from soybean oil presents major environmental damage in seven categories of analyzed impacts (destruction of abiotic resources, destruction of the ozone layer, human toxicity, freshwater ecotoxicity, terrestrial ecotoxicity, acidification and eutrophication). The production process of biodiesel from tallow presents major environmental damage in two categories of impacts analyzed (land use and global warming). However, the results show that the absolute values of environmental damage caused by impacts of the production process using beef tallow are much more aggressive.
Hybrid sediment transport model for the “linguado” channel, state of Santa Catarina, Brazil
Authors: Santos Edison Conde Perez dos , Cosenza Carlos Alberto Nunes , Amorim José Carlos Cesar
Published: December 2017

This study involves an assessment of various artificial intelligence-related techniques which aim to produce a more robust system for sediment transport modeling. The intelligent systems developed in this research are directly applicable to academic knowledge and use data from a report on "water circulation assessment in the “Linguado” Channel and Babitonga Bay ,”Santa Catarina”, Brazil, developed by  Military Engineering Institute (IME). The solution employed for sediment transport was built using an intelligent system from the conception of two hybrid models. The first was a Neuro-Fuzzy (ANFIS) hybrid model for the study of hydrodynamic behavior, aiming to determine flow rate in the channel. The second was a fuzzy genetic model, able to assess sediment transport in the “Linguado” Channel. The study's conclusion compares the different effects involved in the dredging equilibrium in the “Linguado” Channel according to this hybrid model with the results obtained using a finite element model in the MIKE21® software.
Marketing Capabilities in International Marketing
Authors: Morgan Neil A. , Feng Hui , Whitler Kimberly A.
Published: December 2017

There has been a significant increase in scholarly research focusing on marketing capabilities as an important aspect of marketing theory–based explanations of firm performance. This growing research interest in marketing capabilities has also been reflected in the international marketing literature. However, it is unclear whether and how thinking and research about international marketing capabilities differs from that of marketing capabilities in a domestic market context. To explore this question, the authors conduct a review of studies of marketing capabilities in the most influential journals publishing research in international marketing. They supplement this with insights from interviews with executives in firms engaged to varying degrees in international marketing. The study suggests that there remain numerous important unanswered questions in conceptualizing and empirically researching international marketing capabilities.
Strategic Information Transmission in Peer-to-Peer Lending Markets
Authors: Caldieraro Fabio , Zhang Jonathan Z. , Cunha Marcus , Shulman Jeffrey D.
Published: December 2017

Peer-to-peer (P2P) marketplaces, such as Uber, Airbnb, and Lending Club, have experienced massive growth in recent years. They now constitute a significant portion of the world's economy and provide opportunities for people to transact directly with one another. However, such growth also challenges participants to cope with information asymmetry about the quality of the offerings in the marketplace. By conducting an analysis of a P2P lending market, the authors propose and test a theory in which countersignaling provides a mechanism to attenuate information asymmetry about financial products (loans) offered on the platform. Data from a P2P lending website reveal significant, nonmonotonic relationships among the transmission of nonverifiable information, loan funding, and ex post loan quality, consistent with the proposed theory. The results provide insights for platform owners who seek to manage the level of information asymmetry in their P2P environments to create more balanced marketplaces, as well as for P2P participants interested in improving their ability to process information about the goods and services they seek to transact online.
The Impact of Mergers and Acquisitions on the Sales Force
Authors: Bommaraju Raghu , Ahearne Michael , Hall Zachary R. , Tirunillai Seshadri , Lam Son K.
Published: December 2017

This research draws from the psychodynamic perspective of social identity theory to examine the causal effect of mergers and acquisitions involving a mismatch of external images on the sales force. Study 1, a natural longitudinal experiment, shows that a merger with a poorer-image firm immediately dilutes salespeople's organizational identification (OI), which in turn impairs their performance. As sense makers, salespeople who are more tenured experience stronger OI dilution, whereas those who perceive a high level of social inclusion experience weaker OI dilution. As sense givers, managers who emphasize the firm's strategic intent in their communication buffer the OI-dilution effect, whereas those who emphasize the firm's organizational culture aggravate the effect. Study 2, a scenario-based experiment, further demonstrates that the OI-dilution effect is stronger than the OI-enhancement effect from merging with a better-image firm. Furthermore, both studies confirm that the adverse effect of mergers and acquisitions that involve a mismatch of external image stems from image uncertainty rather than job uncertainty.
Periodización y diacronía de los marcadores discursivos de distanciamiento: la etapa del español moderno
Authors: Garcés Gómez María Pilar
Published: December 2017

The aim of this paper is to show the relevance of the first centuries of the modern age, especially the XVIII and the XIX centuries, for the history of the Spanish language as far as the creation and consolidation of new discourse markers are concerned. The development of new genres and discursive models involves different ways of constructing the discourse as well as the necessity of incorporating new markers to implement different discursive functions. In some cases these innovations are realized via grammaticalization through expansion processes fostered by a semantic change which itself has been created by the conventionalization of inferences associated to a construction. In other cases, the above-mentioned innovations are directly incorporated by adaptation or borrowing words from other languages in which they already had a fully-developed discursive function. In order to prove these claims, the author focuses on the analysis of a set of distance reformulative markers that emerged in the first centuries of the modern age and which show these processes in a manifest way.
Blended learning versus traditional teaching-learning-setting: Evaluation of cognitive and affective learning outcomes for the inter-professional field of occupational medicine and prevention / Blended Learning versus traditionelles Lehr-Lernsetting: Evaluierung von kognitiven und affektiven Lernergebnissen für das interprofessionelle Arbeitsfeld Arbeitsmedizin und Prävention
Authors: Eckler Ursula , Greisberger Andrea , Höhne Franziska , Putz Peter
Published: December 2017

Blended learning is characterised as a combination of face-to-face teaching and e-learning in terms of knowledge transfer, students’ learning activities and reduced presence at the teaching facility. The present cohort study investigated long-term effects of blended learning regarding cognitive outcomes as well as self-indicated estimates of immediate learning effects on the affective domain in the inter-professional field of occupational medicine. Physiotherapy students (bachelor degree) at FH Campus Wien – University of Applied Sciences completed the course Occupational Medicine/Prevention either in a traditional teaching-learning setting entirely taught face-to-face (control-group, n=94), or with a blended learning model (intervention-group, n=93). Long-term effects (1.5 year follow-up) on the cognitive learning outcomes were assessed according to four levels of Bloom’s learning objectives. In addition, students estimated potential benefits resulting from blended learning based on four Krathwohl’s learning objectives for the affective domain by means of a six-option Likert scale (n=282). Concerning cognitive outcomes, significant results favouring both groups were found with effect sizes from small to medium. The traditional teaching-learning setting resulted in significantly better results in the upmost aspired learning objective (analysis) at the long-term (p<0,01; r=-0,33). In contrast, the intervention group resulted in significantly better long-term results on learning objective levels 1 (knowledge) and 2 (understanding) (p=0,01; r=-0,20 and, p=0,02; r=-0,17, respectively). Hence, no general recommendation favouring either the classical setting or blending learning can be drawn regarding the cognitive domain. However, students’ self-indications on the affective domain give preference to blended learning, particularly if inter-professional teamwork is a course objective.
A Cross-layer Traffic Grooming Algorithm in Joint Optimization of the IP over Elastic Optical Network
Authors: Zhao Jijun , Xu Yuehuan , Ren Danping , Hu Jinhua
Published: December 2017

To fully utilize the existing optical network resource, the dynamic traffic grooming technology, which could efficiently multiplex many low-speed services arriving dynamically onto high-capacity optical channels, has been studied extensively and used widely. In this article, the problem of dynamic traffic grooming in joint optimization of IP over elastic optical network (EON) is studied. This problem consists of three sub-problems at two layers: the routing problem at the IP-layer (IPR), the routing, modulation level (RML), and the spectrum allocation (SA) problems at the optical layers. We proposed a novel topology-integration and adaptive-modulation based in cross-layer routing spectrum allocation (CL-RSA) algorithm, which follows a multi-cost approach that solves the IPR, the RML, and the SA problems jointly. The most important features of the proposed algorithm are merging physical topology with virtual topology and using the minimum-weight preferred method for route selection. Meanwhile, the effect of physical-layer impairments (PLI) on signal transmission is considered. In addition, the adaptive modulation scheme is used to allocate the spectrum resource. The simulation results show that the algorithm can effectively improve the spectrum resource utilization and reduce the network blocking probability compared to other algorithms in various network conditions, especially in the high load condition effectively.
Die Gerechtigkeitslücke in der Verteilung der Kosten der Energiewende auf die privaten Haushalte
Authors: Frondel Manuel , Kutzschbauch Ole , Sommer Stephan , Traub Stefan
Published: December 2017

Die Energiewende bürdet den Verbrauchern zunehmende Lasten auf, die diese vor allem mit ihrer Stromrechnung zu begleichen haben. Die Ergebnisse der vorliegenden empirischen Studie zeigen, dass in der Regel eine Aufteilung der Kosten der Energiewende gewünscht wird, die Haushalte mit hohen Einkommen vergleichsweise stärker in die Pflicht nimmt. Die auf dieser Grundlage konstatierte Gerechtigkeitslücke zwischen der gewünschten und der tatsächlichen Kostenbelastung privater Haushalte nimmt mit den wachsenden Kosten der Energiewende voraussichtlich weiter zu. Diese Lücke könnte im Prinzip leicht geschlossen werden, wie die in diesem Beitrag dargestellten empirischen Schätzungen der Zahlungsbereitschaft der Haushalte für die Förderung der Erneuerbaren auf Basis von Diskrete-Wahl-Modellen nahelegen. So könnten die einkommensstärkeren Haushalte bei der Finanzierung der Energiewende stärker als bislang in die Pflicht genommen werden, da diese eine statistisch signifikant höhere Zustimmung zu zukünftigen EEG-Umlageerhöhungen zeigen als einkommensschwache Haushalte.
Vector Monte Carlo algorithms with finite computational cost
Authors: Medvedev Ilia N.
Published: December 2017

The issues of finite computational cost of some vector weighted Monte Carlo algorithms are studied in the paper relative to estimation of linear functionals of solutions to systems of the 2nd kind integral equations. A universal modification of the weight vector collision estimator with branching of the chain trajectory relative to the elements of matrix weight is constructed. It is proved that the computational cost of the constructed algorithm is finite in the case when the basic functionals are bounded. The results of numerical calculations are presented for the case of use of a modified weight estimator for some problems of the radiation transfer theory with allowance for polarization.
Bilateral Trade Elasticity of Serbia and Her Trading Partners
Authors: Kurtovic Safet , Halili Blerim , Maxhuni Nehat
Published: December 2017

Almost all countries face the problems of trade balance, although they are more inherent in developing countries and economies in transition. A majority of economists adhere to a common opinion that real depreciation may lead to an improvement of trade balance. That said, countries encountering trade balance issues use real exchange rate depreciation in order to improve trade balance. In fact, this research refers to the assessment of bilateral elasticity effect of real exchange rate depreciation and the income on export and import demand function of Serbia and its nine leading partners. 2004Q1-2015Q4 data and ARDL approach have been used in this research. The results obtained show the presence of the J-curve in cases of Germany, Austria and Croatia. On the other hand, we examined if the Marshall-Lerner condition was fulfilled in the case of bilateral trade with Austria. Finally, we found that the elasticity of income has a greater effect on the export and import demand function, in relation to the elasticity of the exchange rate.
Characterization of CRM Binders with Wax Additives Using an Atomic Force Microscopy (AFM) and an Optical Microscopy
Authors: Kim Hyun Hwan , Mazumder Mithil , Torres Anthony , Lee Soon-Jae , Lee Moon-Sup
Published: December 2017

This paper investigates the change in micromorphology of two binders and their respective warm mix asphalt binders before and after aging using atomic force microscopy (AFM) and optical microscopy. The control (PG 64-22) and crumb rubber modified (CRM) binders were blended with two different types of wax additives (L, a wax-based composition including crystal controller, and S, a long chain aliphatic hydrocarbon) and then artificially short-term and long-term aged using the rolling thin film oven and pressure aging vessel procedures. L is a wax based composition including crystal controller and S is a long chain aliphatic hydrocarbon. The AFM tapping-mode imaging technique was used to analyze the microstructure and the Superpave asphalt binder test was used to measure the rheology properties. In general, the results of this study indicated that (1) a correlation was observed between the changes in micromorphology (the distribution of dispersed domains and matrix) and rheology properties regardless of the aging, binder, and wax types; (2) the addition of crumb rubber into the base binder decreased the dimension of the catana phase (“bee-like”) structure, which increased the quantity of these structures; (3) the opposite trend was found between the aged control binder and the aged CRM binder regarding the size of the bee-like structure; (4) the long-term aging seemed to have a significant effect on the microstructures of the warm control and CRM binders; and (5) the inclusion of S and L was observed to have a similar trend for both binder types in terms of increased size of the bee-like structure and no bee-like structure, respectively.
Extracting More from Dynamic Modulus Data Using Split-Plot Repeated Measures Analysis
Authors: Buss Ashley , Elkashef Mohamed , Stephenson W. Robert
Published: December 2017

Dynamic modulus testing and the development of master curves is an essential test used to characterize asphalt mixes. The dynamic modulus values are used in the mechanisitic-emprical pavement design guide that is being implemented by many state agencies. To compare dynamic modulus values, most researchers use master curves to analyze the values; however, the log-log scale of the master curve masks the differences between the mixes, requiring the use of an appropriate and reliable statistical data analysis approach to make accurate comparisons between mixes. In this paper, a full experimental plan is designed to investigate the effect of three different factors on the dynamic modulus, namely (1) type of mix: hot mix asphalt versus warm mix asphalt, (2) impact of reheating, and (3) moisture conditioning of specimens. An open-access statistical software package, “R,” is used for the analysis. The data showed that the type of mix and moisture conditioning were statistically significant factors. The statistical analyses presented in this paper begin with a simplified approach and then become increasingly comprehensive. The simplified approach considers a single temperature and frequency only. A more encompassing approach, with the aid of split-plot repeated measures (SPRM) analysis, is then performed in which each of the three factors is considered separately. This is followed by a full analysis on the entire data set that takes into account the interaction between all factors. The benefits of performing a full analysis in lieu of a simplified analysis are highlighted and a detailed interpretation of the results is given.
Transcranial Alternating Current Stimulation Modulates Risky Decision Making in a Frequency-Controlled Experiment
Authors: Yaple Zachary , Martinez-Saito Mario , Awasthi Bhuvanesh , Feurra Matteo , Shestakova Anna , Klucharev Vasily
Published: December 2017

In this study, we investigated the effect of transcranial alternating current stimulation (tACS) on voluntary risky decision making and executive control in humans. Stimulation was delivered online at 5 Hz (θ), 10 Hz (α), 20 Hz (β), and 40 Hz (γ) on the left and right frontal area while participants performed a modified risky decision-making task. This task allowed participants to voluntarily select between risky and certain decisions associated with potential gains or losses, while simultaneously measuring the cognitive control component (voluntary switching) of decision making. The purpose of this experimental design was to test whether voluntary risky decision making and executive control can be modulated with tACS in a frequency-specific manner. Our results revealed a robust effect of a 20-Hz stimulation over the left prefrontal area that significantly increased voluntary risky decision making, which may suggest a possible link between risky decision making and reward processing, underlined by β-oscillatory activity.
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties
Authors: Sharma Vijendra , Ounallah-Saad Hadile , Chakraborty Darpan , Hleihil Mohammad , Sood Rapita , Barrera Iliana , Edry Efrat , Kolatt Chandran Sailendrakumar , Ben Tabou de Leon Shlomo , Kaphzan Hanoch , Rosenblum Kobi
Published: December 2017

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 α (eIF2α) or other signal transduction cascades. Recently, both eIF2α and its kinases were found to play a role in normal and pathological brain function. Here, we show that reduction of either the amount or the activity of PERK, specifically in the CA1 region of the hippocampus in young adult male mice, enhances neuronal excitability and improves cognitive function. In addition, this manipulation rescues the age-dependent cellular phenotype of reduced excitability and memory decline. Specifically, the reduction of PERK expression in the CA1 region of the hippocampus of middle-aged male mice using a viral vector rejuvenates hippocampal function and improves hippocampal-dependent learning. These results delineate a mechanism for behavior and neuronal aging and position PERK as a promising therapeutic target for age-dependent brain malfunction.

SIGNIFICANCE STATEMENTWe found that local reduced protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) expression or activity in the hippocampus enhances neuronal excitability and cognitive function in young normal mice, that old CA1 pyramidal cells have reduced excitability and increased PERK expression that can be rescued by reducing PERK expression in the hippocampus, and that reducing PERK expression in the hippocampus of middle-aged mice enhances hippocampal-dependent learning and memory and restores it to normal performance levels of young mice. These findings uncover an entirely new biological link among PERK, neuronal intrinsic properties, aging, and cognitive function. Moreover, our findings propose a new way to fight mild cognitive impairment and aging-related cognitive deterioration.
An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4
Authors: van Battum Eljo Y. , Verhagen Marieke G. , Vangoor Vamshidhar R. , Fujita Yuki , Derijck Alwin A.H.A. , O'Duibhir Eoghan , Giuliani Giuliano , de Gunst Thijs , Adolfs Youri , Lelieveld Daphne , Egan David , Schaapveld Roel Q.J. , Yamashita Toshihide , Pasterkamp R. Jeroen
Published: December 2017

During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian CNS is limited in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing CNS regeneration. Here, we performed one of the first miRNome-wide functional miRNA screens to identify miRNAs with robust effects on axon growth. High-content screening identified miR-135a and miR-135b as potent stimulators of axon growth and cortical neuron migrationin vitroandin vivoin male and female mice. Intriguingly, both of these developmental effects of miR-135s relied in part on silencing of Krüppel-like factor 4 (KLF4), a well known intrinsic inhibitor of axon growth and regeneration. These results prompted us to test the effect of miR-135s on axon regeneration after injury. Our results show that intravitreal application of miR-135s facilitates retinal ganglion cell (RGC) axon regeneration after optic nerve injury in adult mice in part by repressing KLF4. In contrast, depletion of miR-135s further reduced RGC axon regeneration. Together, these data identify a novel neuronal role for miR-135s and the miR-135–KLF4 pathway and highlight the potential of miRNAs as tools for enhancing CNS axon regeneration.

SIGNIFICANCE STATEMENTAxon regeneration in the adult mammalian CNS is limited in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing regeneration. By performing an miRNome-wide functional screen, our studies identify miR-135s as stimulators of axon growth and neuron migration and show that intravitreal application of these miRNAs facilitates CNS axon regeneration after nerve injury in adult mice. Intriguingly, these developmental and regeneration-promoting effects rely in part on silencing of Krüppel-like factor 4 (KLF4), a well known intrinsic inhibitor of axon regeneration. Our data identify a novel neuronal role for the miR-135–KLF4 pathway and support the idea that miRNAs can be used for enhancing CNS axon regeneration.
A univocidade do común. Un percorrido
dende Spinoza a Deleuze, Lazzarato e Negri-Hardt
Authors: Rubín Abraham
Published: December 2017

El concepto de común es fundamental para construir una teoría política igualitaria, perosi queremos acercarnos a este concepto de lo común con rigor, creemos que es imprescindiblepensar primero un concepto unívoco de ser a partir de Spinoza, que además será clave paraentender a autores como Antonio Negri, Gilles Deleuze o Maurizio Lazzarato, que continuarány asumirán ese camino con el fin de apuntalar una lectura ontológica “común” del ser,antijerárquica e inmanente, lo que ya es una visión política. Una de las maneras es a través dela figura de la multiplicidad y la máquina deleuziana, que nos servirá para ver un ejemplo deconstrucción conceptual común desde la inmanencia; otro modo es a través del concepto deagenciamiento, empleado por Deleuze-Guattari y asumido por Lazzarato en su concepciónpolítica. Por último, el papel de la multitud en este terreno —entendiendo ésta como unasubjetividad política— deviene también importante, motivo por el cual seguiremos a Negri-Hardt en la caracterización que hacen de ella.
Claude Lévi-Strauss y el estructuralismo metateórico sneedeano
Authors: Jaramillo Juan Manuel
Published: December 2017

El objeto de este artículo es mostrar las similitudes que existen entre el estructuralismo metateórico sneedeano y la que considero es la propuesta teórica más desarrollada del estructuralismo francés, la teoría antropológica de Claude Lévi-Strauss, en particular, su teoría de los sistemas elementales de parentesco. Aunque entre el estructuralismo francés de Lévi-Strauss (al igual que con otros estructuralismos) y el estructuralismo metateórico sneedeano sólo existe, como diría Wittgenstein, un “aire de familia” (Familienähnlichkeit), sin embargo, quiero mostrar que gracias al trabajo algebraico de André Weil y, en particular, a su clarificación de la noción de estructura, existe un “puente” entre la propuesta teórica de Lévi-Strauss y la metateórica del estructuralismo inaugurada por J. D. Sneed en 1971 con la publicación de su libro The logical structure of mathematical physics.
¿Por qué Aristóteles no apoyaría la teoría del diseño inteligente?
Authors: Picón Casas Javier
Published: December 2017

La teoría del diseño inteligente ha irrumpido en el panorama cultural de un modo extraño. Algunos ecos del antisemitismo resuenan en el antidarwinismo. Los biólogos ignoran el creacionismo que, sin embargo, significativos estamentos políticos apoyan más allá del Atlántico. Convendría combatir ese populismo hostil a la ciencia. De hecho, podríamos recordar por qué los biólogos de la antigüedad estarían de acuerdo con el darwinismo. Trataremos mostrar un gran ejemplo: Aristóteles.
Michael Oakeshott, Wendy Brown, and Paradoxes of Anti-moralism
Authors: Laursen John Christian
Published: December 2017

El filósofo británico Michael Oakeshott es muy conocido por su crítica del idealismo moral racionalista. El ha sido acusado en ocasiones de conservadurismo porque alguno de los moralismos racionales que critica son socialistas o izquierdistas. Sin embargo, la pensadora Wendy Brown que se autodefine como progresista también critica el moralismo en la política a veces con las mismas razones. Interlocutores recientes en debates sobre moralismo racionalista han intentado aconsejar cómo evitar el moralismo racionalista, pero es uno de los vicios que uno identifica en otros, mucho antes que en uno mismo. Volver a alguno de los aspectos de la filosofía de Oakeshott nos ayuda a aclarar los problemas y proporcionar algunas orientaciones para proseguir el debate.
La obra de arte como fin del mundo. Exotismo y sombra en el pensamiento estético de Emmanuel Levinas
Authors: Llorente Jaime
Published: December 2017

El presente estudio trata de exponer y analizar los principales conceptos del pensamiento estético de Emmanuel Levinas desde una perspectiva de interpretación centrada en el significado ontológico subyacente a las ideas levinasianas acerca de la percepción de la obra de arte y la esencia de la experiencia estética en general. Las dos nociones clave que ponen de manifiesto el trasfondo «metafísico» de la teoría del arte de Levinas son «exotismo» y «sombra». Ambas hacen referencia, aunque en distinto sentido, al modo en el que la mirada estética rasga la continuidad de las formas que constituyen el mundo percibido, permitiendo así a la sensación el acceso al ámbito nocturno, informe y definido por la alteridad que se oculta tras él.
Biotecnología y naturaleza humana. La cuestión del posthumanismo
Authors: Galparsoro José Ignacio
Published: December 2017

El hombre es el único animal que cree haber comprendido el mecanismo que le ha llevadohasta su presente como especie. Comprender este proceso es el primer paso, al que le puedeseguir la consideración de la posibilidad de actuar sobre él de manera consciente. Al hombrese le abre la posibilidad de actuar, mediante la biotecnología, sobre el proceso evolutivo paratratar de «mejorar» sus prestaciones biológicas, atravesando el umbral de la humanidad conel fin de lograr una condición «posthumana». La cuestión del posthumanismo es objeto deun encendido debate que el artículo trata de reflejar.
El valor en la ética del discurso: una revisión de las objeciones de Putnam a Habermas y algunas observaciones sobre la racionalidad axiológica
Authors: Molina González Yohan Manuel
Published: December 2017

En su conferencia “Valores y normas”, Hilary Putnam critica la ética discursiva de Habermas desde la evidencia de la necesidad de un sustrato cognitivo del valor, elemento que según la óptica putnamiana Habermas no aceptaría, para poder fundamentar cabalmente el estatuto universal de las normas morales. Aunque Habermas no responde directamente las preocupaciones de Putnam, da a entender que no piensa que los valores son ajenos a la discusión racional, solo que esta racionalidad estaría limitada por un marco de asuntos particulares y, por lo tanto, por un plano práctico extraño a la perspectiva universal. En nuestro trabajo nos plantearemos una reconstrucción rigurosa de las objeciones de Putnam para luego desafiar su interpretación escéptica del valor en la obra de Habermas a partir de algunas consideraciones expuestas por el propio autor alemán, y, sobre esta base, criticar el abordaje habermasiano de la racionalidad axiológica por considerarlo poco exhaustivo y problemático.
El Realismo de Leyes Naturales: ¿en qué consiste?
Authors: Rojas Durán Edgar Eduardo
Published: December 2017

El presente trabajo tiene como propósito responder la pregunta ¿en qué consiste el realismo de leyes naturales? Para lograr esto, en la primera sección, se exponen y analizan tres teorías filosóficas de leyes naturales: la universalista, la disposicionalista y la contra-factualista. Esta exposición y análisis se centra en la respuesta que cada una de éstas da a la pregunta ¿qué es una ley natural? Posteriormente, en la segunda sección, se muestran tanto las convergencias y divergencias encontradas en ellas. Finalmente, en la tercera sección, se conjuntan los puntos que comparten para presentar la tesis que las engloba a todas como teorías de leyes realistas. Esta tesis, afirmo, es en el fondo el núcleo de la posición realista general sobre leyes naturales que denomino “Realismo de Leyes Naturales”.
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish
Authors: Xia Hui , Zhong Chengrong , Wu Xingxing , Chen Ji , Tao Binbin , Xia Xiaoqin , Shi Mijuan , Zhu Zuoyan , Trudeau Vance L , Hu Wei
Published: December 2017

N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A modification in multiple biological processes, but the in vivo function of m6A has been difficult to study, because mettl3 mutants are embryonic lethal in both mammals and plants. In this study, we have used transcription activator-like effector nucleases and generated viable zygotic mettl3 mutant, Zmettl3m/m, in zebrafish. We find that the oocytes in Zmettl3m/m adult females are stalled in early development and the ratio of full-grown stage (FG) follicles is significantly lower than that of wild type. Human chorionic gonadotropin-induced ovarian germinal vesicle breakdown in vitro and the numbers of eggs ovulated in vivo are both decreased as well, while the defects of oocyte maturation can be rescued by sex hormone in vitro and in vivo. In Zmettl3m/m adult males, we find defects in sperm maturation and sperm motility is significantly reduced. Further study shows that 11-ketotestosterone (11-KT) and 17β-estradiol (E2) levels are significantly decreased in Zmettl3m/m, and defective gamete maturation is accompanied by decreased overall m6A modification levels and disrupted expression of genes critical for sex hormone synthesis and gonadotropin signaling in Zmettl3m/m. Thus, our study provides the first in vivo evidence that loss of Mettl3 leads to failed gamete maturation and significantly reduced fertility in zebrafish. Mettl3 and m6A modifications are essential for optimal reproduction in vertebrates.
El ensayo lírico como experiencia estética-hermenéutica (The Lyric Essay as an Aesthetic-Hermeneutical Experience)
Authors: Hernández Carmona Luis Javier
Published: December 2017

Se plantea la teorización sobre el ensayo lírico y la generación de la experiencia estética-hermenéutica, a partir de la aplicación de la ontosemiótica como perspectiva metodológica. Con ello, se analizan las prácticas discursivo-literarias que contienen la metarreflexión que desde la extratextualidad da respuesta a los planteos metaforizados, dado que la autonomía del texto y los desdoblamientos del sujeto enunciador implican estrategias de análisis centradas en el cuadrante referencial autor-texto-lector-contexto. Se analizan teorías sobre el ensayo según Montaigne, Lukács, Adorno y Nicol, hasta proponer el ensayo como balance entre lo objetivo y lo subjetivo trascendente. Abstract A theorization is proposed for the lyric essay and the generation of the aesthetic-hermeneutic experience from the application of ontosemiotics as a methodological perspective. A discussion is presented of discursive-literary practices containing meta-reflection which, from extratextuality, responds to metaphorized approaches that for the autonomy of the text and the splits of the enunciating subject require analytical strategies focusing on the referential quadrant author-text-reader-context. Theories on the essay are reviewed, including those of Montaigne, Lukács, Adorno and Nicol, to propose the essay as a balance between the objective and transcendental subjectivity.