bluuebunny/crossref_metadata_2025 huggingface dataset:
A 15-year Follow-Up of a Gingivectomy Procedure for Idiopathic Gingival Fibromatosis: A Case Report and Literature Review
Authors: Seki Keisuke , Sato Shuichi
Published: May 2022

Few long-term reports exist concerning the treatment of idiopathic gingival fibromatosis, which is a rare autosomal dominant genetic disorder associated with non-inflammatory, benign, and chronic fibrous gingival proliferation and which causes serious esthetic problems.

The aim of this study was to report a case of idiopathic gingival fibromatosis treated with a gingivectomy using an inverse bevel flap method and comprehensively followed up for 15 years. A female patient visited a pediatric dentist at 7 years of age; however, a gingivectomy was not performed until the age of 20 years because of an uncertain prognosis. Now, more than 15 years after the gingivectomy, there has been no significant recurrence and the disease is well managed. Treatment by gingivectomy with an inverse bevel flap approach may provide long-term prevention of recurrence of gingival fibromatosis into adulthood. The aim of this study was to obtain new findings on the pathogenesis and prognosis of this rare disease and to review the case reports previously published.
Virtualization of the Educational Process in the Training of Future Primary School Teachers
Authors: Tovkanets Anna , Tovkanets Oksana
Published: May 2022

Celem artykułu jest uzasadnienie cech wirtualizacji procesu edukacyjnego w kształceniu przyszłych nauczycieli szkół podstawowych w ukraińskim szkolnictwie wyższym. Wykorzystano następujące metody badań naukowych: kwestionariusze i analiza danych statystycznych – w celu wyjaśnienia rozumienia przez wnioskodawców przestrzeni wirtualnej oraz zidentyfikowania zalet i sprzeczności wykorzystania kształcenia na odległość w profesjonalnym kształceniu pedagogicznym; analiza teoretyczna – do określenia głównych podejść teoretycznych do kształcenia na odległość i roli takiego kształcenia w procesie edukacyjnym; uogólnienie – do sformułowania wniosków dotyczących wirtualizacji procesu edukacyjnego w kształceniu przyszłych nauczycieli szkół podstawowych. Okazało się, że wykorzystanie technologii w zdalnym kształceniu zawodowym przyszłych nauczycieli wymaga różnorodnych form, metod i technik wirtualnego wsparcia kształcenia zawodowego i ogólnokulturowego. Nacisk kładziony jest na tradycyjne (zasady świadomości i aktywności uczenia się, systematyczność i konsekwencja, dostępność uczenia się, celowość) i specyficzne (zasady modułowej konstrukcji treści działań edukacyjnych i poznawczych, przejście od uczenia się do samokształcenia, kolektywny charakter uczenia się i uwzględniania indywidualnych cech uczniów) zasady budowania kształcenia na odległość. Określono typy uczniów ze względu na charakter działalności edukacyjnej i odpowiadające im modele zachowań w warunkach kształcenia na odległość. Ujawniane są cechy wirtualizacji środowiska edukacyjnego uniwersytetu podczas szkolenia zawodowego przyszłych nauczycieli: szkolenie w oparciu o metodę projektów; korzystanie z serwisów społecznościowych i innych portali społecznościowych i informacyjnych, które pomagają zwiększać potencjał twórczy i intelektualny w oparciu o samoorganizację, pragnienie wiedzy, umiejętność interakcji z nowoczesną technologią komputerową; rozszerzone możliwości zaangażowania partnerów społecznych i nawiązania współpracy ze środowiskiem naukowym podczas realizacji wspólnego projektu lub przy tworzeniu innowacyjnego produktu komunikacyjnego; stworzenie systemu komunikacji od ucznia do nauczyciela, do międzynarodowego środowiska naukowego, do partnerów, pomagającego podnieść poziom ogólnego rozwoju intelektualnego w realizacji innowacyjnych projektów, a także podtrzymującego zainteresowanie innowacyjnymi, badawczymi, kreatywnymi, niezależnymi działaniami w zakresie tworzenia i realizacji projektów.
Hereditary Breast Cancer
Authors: Fernández Ángel , Reigosa Aldo
Published: May 2022

Breast cancer occurs when breast cells grow out of control because they escape the fine controls that regulate cell multiplication, resulting in cell proliferation unresponsive to regulation. Most cases of breast cancer have no identifiable cause, but approximately 5% to 10% are caused by inherited genetic mutations. Although other genes are known to cause hereditary breast cancer, most studies evaluating clinical management strategies have focused on women with mutations in the BRCA1 or BRCA2 (Breast Cancer) genes. People with these mutations have a significantly increased lifetime risk of cancer compared to the general population.
The Rare Occurrence of Splenic Metastasis of Cervical Cancer: A Case Report
Authors: Villalón-López José Sebastián , Bosque Rosalía Souto-del , Montañez-Lugo Juan Ignacio , Chávez-González Bruno
Published: May 2022

Splenic metastasis of solid tumors has a low occurrence rate and an incidence of only 2.9%–9%. Given its rarity, only a few cases of splenic metastasis of cervical cancer have been reported. This report presents a case of 76-year-old woman with stage IB1, moderately differentiated adenocarcinoma of cervix, coupled with invasion of cervical stroma and cervical canal. The patient had a cancer antigen 125 (CA-125) level of 150 U/ml and was treated with hysterictomy and pelvic lymphadenectomy. She received 45 Gy pelvic radiotherapy and then 24 Gy brachytherapy. She developed abdominal pain two years later. Computed tomography (CT) examination found two solid lesions of the spleen and no lesions in the rest of the abdominal cavity and chest. Her CA-125 level increased to 2,733 U/ml. Histopathological findings showed splenic metastasis of well differentiated adenocarcinoma in cervix. Immunohistochemical tests revealed that the tumor was positive for carcinoembryonic antigen and negative for estrogen and progesterone receptors. Eight weeks after operation, CA-125 level of the patient was 16 U/ml. She received adjuvant therapy consisting of paclitaxel and cisplatin for 6 cycles. After being followed up for 12 months, the patient was still alive and had no evidence of tumor activity. The spleen is a rare metastatic site. Splenectomy is considered an appropriate treatment to prevent complications, such as splenic rupture and splenic vein thrombosis, and reduce the pain caused by splenomegaly.
Correlation between Ultrasound and CT in the Diagnosis of Bladder Cancer
Authors: Rodríguez Andrés Manuel Martín , Vaillant Solangel Bolaños , Moya Clara Pereira , Acosta Mirelvis Musle , Fajardo José Daniel García
Published: May 2022

Introduction: Effective and early diagnosis of bladder cancer is very important to achieve potential treatment and improve the survival rate of affected patients. Objectives: To describe the ultrasonographic and computerized tomography (CT) findings of bladder malignant tumors. Method: An observational, descriptive and cross-sectional study was conducted from January 2013 to December 2017 on 250 patients with bladder cancer who previously underwent ultrasound and CT examinations in the Imaging Department of Saturnino Lora Provincial clinical surgery teaching hospital in Santiago, Cuba. Result: In this series, men over the age of 60 were more commonly diagnosed with bladder cancer. Ultrasound examination showed that in addition to the characteristics of calcification, necrosis, adenosis and infiltration of adjacent structures were observed. Ultrasound examination also showed dominant sonographic structures and clear tumors larger than 3 cm and vascularized tumors. On CT, the mixed structure, space occupying tumor and ultrasonic features were almost identical between the two diagnostic methods. Conclusion: Compared with CT, the sonogram of bladder cancer is mixed and ultrasonic, which makes the diagnosis of the bladder cancer more feasible. However, the features and details displayed by CT were consistent with other imaging techniques.
Racotumomab Therapeutic Vaccine in the Treatment of Advanced Lung Cancer in the Elderly: A Case Report
Authors: Casola Tatiana Hernández , Ferrer Héctor Luis Salazar , Cruz Isela Companioni de la
Published: May 2022

We reported a clinical case of an 84-year-old smoker who was diagnosed with stage IV lung cancer and was included in the phase III clinical trial and treated with racotumomab. The patient had a an ECOG grade 0 according to the function scale. Therefore, it should be emphasized that this vaccine can improve the survival rate of patients with recurrent or advanced non-small cell lung cancer.
Prognostic Markers and Detection Approaches of Bladder Cancer
Authors: Zhang Nan , Zhang Fuhan , Shi Mengran , Yang Zhao , Li Chong
Published: May 2022

Bladder cancer (BC) is one of the most commonly diagnosed cancers in men worldwide. Numerous treatments of BC are available, but it is noteworthy that BC patients have heterogeneous responses to these treatments. Therefore, the prognostic markers, which are associated with clinical outcomes, are vital for formulating BC treatment plan. This review provides an overview of prognostic markers and their importance in early diagnosis and recurrence of BC. Apart from that, this review discusses the application of prognostic markers and their related population studies. A deeper understanding of these prognostic markers and their prognostic value would aid in designing treatment strategies, predicting response to treatment, and managing the clinical care for BC in future.
Clinical Characteristics of Patients with Colon Cancer
Authors: Adolfo Luis Andrés Guibert , Meriño Luis Ernesto Quiroga , Brizuela Yarima Estrada , Ramos Osmany Mario Maestre , León Germán Guilarte
Published: May 2022

Background: Colon cancer is the third leading cause of cancer morbidity and mortality in the world. Objectives: To investigate the clinical characteristics of patients with colon cancer. Methods: A cross-sectional descriptive study was used to analyze the characteristics of colon cancer patients in the Service of General Surgery of Military Hospital Octavio de la Concepción y la Pedraja from October 2013 to August 2017. The universe consisted of 61 patients with colon cancer. Results: The study was mainly female, and the patients over 60 years old accounted for the majority, especially the patients in the age group of 70–79 years old. Villous adenoma was the most common history. Low gastrointestinal bleeding was the main manifestation of left tumor patients. Most cancers were well differentiated. Adenocarcinoma was the most common histological type. Conclusion: Villous adenoma was the main pathological history of women aged 70–79. Lower gastrointestinal bleeding was the most common clinical manifestation, which was related to left position. Some patients need surgical treatment, and the most commonly used technique was left hemicolectomy. Most tumors were well differentiated with chronic inflammation.
Analysis of Prognostic Factors of Colorectal Cancer Liver Metastasis after Microwave Ablation
Authors: Tan Shuyun , Huang Pinzhu , Peng Shaoyong , Zhou Jiaming , Liu Guangjian , Li Tuoyang , Huang Meijin
Published: May 2022

Objective: To investigate the risk factors associated with intrahepatic recurrence and survival after microwave ablation (MWA) for colorectal cancer with liver metastases. Methods: Retrospective analysis of clinical, pathological and follow-up data of 60 patients who underwent ultrasound-guided microwave ablation for treating liver metastases from January 2013 to December 2015 at the Sixth Affiliated Hospital, Sun Yat-Sen University, with Cox univariate and multifactorial regression analyses of risk factors affecting intrahepatic recurrence and overall survival after ablation of liver metastases. Results: After follow-up for 12.5 to 47.4 months, intrahepatic recurrence occurred in 26 cases, of which 6.1% (7/114) showed local tumor progression at the original ablation site; 11 cases died for tumor-related reasons. Multi-factor Cox regression analysis showed that age ≥60 years and maximum diameter of liver metastases ≥2 cm were independent risk factors for patients to develop intrahepatic recurrence after surgery. HBsAb positivity and chemotherapy after ablation until intrahepatic recurrence are independent protective factors for patients developing intrahepatic recurrence after surgery. Multi-factor Cox regression analysis showed that the number of liver metastases ≥3 was an independent risk factor for overall survival. Conclusion: After microwave ablation for patients with colorectal cancer liver metastases, patients aged ≥60 years, HBsAb negative and with maximum liver metastases ≥2 cm in diameter were more likely to have recurrent intrahepatic metastases, while aggressive chemotherapy after ablation was effective in reducing recurrent intrahepatic metastases, and the number of liver metastases ≥3 indicated a poor overall prognosis.
Research Progress on the Abnormal Expression of Galectin-3 and p16 in Cervical Cancer
Authors: Yang Minghan , Ma Qiushuang , Zhang Jinku
Published: May 2022

Despite the increasing awareness of early diagnosis and treatment has brought about a downtrend in the morbidity and mortality of cervical cancer, recent years have still witnessed an obvious uptrend in the incidence rate among the young patients. Galectin-3 and p16, which play an important role in the incidence and development of cervical cancer and are closely related to its diagnosis and prognosis, are often used as important indicators of the clinical diagnosis of cervical cancer. This article reviews the protein structures of galectin-3 and p16 as well as their expression mechanism and abnormal expression regarding to cervical cancer.
Effectiveness of Sildenafil in Erectile Sexual Dysfunction in Prostate Cancer Patients
Authors: Naún Vilma Ávila , Figueredo Jennifer Martínez , Chávez Rodolfo Martínez , Viñals Terianne Pérez
Published: May 2022

Introduction: Prostate cancer is the first cause of death by cancer in Cuban men and affects the quality of their sexual life. Objective: To investigate the efficacy of sildenafil in the treatment of erectile dysfunction in patients with prostate cancer after hormone or radiotherapy. Method: An observational, double perspective and cross-sectional study was conducted in the Service of Urology of Hospital “Dr. Agostinho Neto” in Guantanamo from 2014 to 2018, which was approved by the medical ethics committee. The study consisted of 70 patients diagnosed with prostate cancer who received hormone therapy or radiotherapy with erectile dysfunction. In each patient, we studied age, cancer treatment, time of postoperative dysfunction, and the response of penile erectile function to the use of sildenafil. Results: 37.2% of the patients were between 70 and 79 years old, and 79.1% of the patients received hormone therapy; the highest proportion of erectile dysfunction occurred 1–2 years after treatment (48.8%); 81.4% responded adequately to sildenafil treatment, which was not related to hormone or radiotherapy for cancer. Conclusions: Prostate cancer patients treated with hormone and/or radiotherapy benefit from the efficacy of sildenafil.
A situated agent-based model to reveal irrigators' options behind their actions under institutional arrangements in Southern France
Authors: Richard Bastien , Bonté Bruno , Barreteau Olivier , Braud Isabelle
Published: May 2022

There has been little exploration of the explicit simulation of the set of options of actors in agent-based models and its evolution over time. This study proposes to use affordances as intermediate entities between agents’ environment and agent actions. We illustrated the approach on a typical gravity-fed network in the South-East of France to explore how the abandonment of traditional sharing of water changes the irrigators’ options to irrigate. We simulated a typical dry year irrigation season under two institutional arrangements (i.e. traditional coordination through daily slots and its abandonment). Simulation results are consistent with field surveys, and reveal an increase in the number of internal conflicts among irrigators as the counterpart of the abandonment of traditional sharing of water. They also highlight the consequences of the heterogeneity of the irrigators' interests within the collective institution. The sensitivity analysis of the model allowed identification of optimal modalities of coordination, and a potential compromise between past and current institutional arrangements. The key benefits of using affordances in ABM lie in the study of their population dynamics for characterizing the interaction situations between actors and their environment and for better understanding the model dynamics.
The changes in lower lid position & laxity post cataract surgery
Authors: Govindaraj Bhavna , Natarajan Manjunath
Published: May 2022

To evaluate the changes relating to lower lid position and laxity after cataract surgery.

This is prospective study evaluating the lower eyelid position of patients who underwent cataract surgery from June to September 2019. Data collected includes duration of the cataract surgery, the duration of the speculum remaining insitu. Also we included measurements relating to the distraction test, distance of the lower lacrimal punctum from the inner canthus, and margin reflex distance 2 (MRD2) were performed 1 day, 2 weeks & 3 months post surgery. The data was analysed in Microsoft Excel & SPSS software.

The study sample comprised 109 cataract patients, all of whom were of South Indian ethnicity, 68 (62.3%) were female with a median age of 74 years, and 67 (61.4%) had surgery in their left eye. The distraction test before surgery was 6.5 ± 0.2 mm, with mild increase after 1 day (7.3 ± 0.3 mm), sustained after 14 days (7.5 ± 0.2 mm), and decreasing after 3 months (7.0 ± 0.5 mm) to a level similar to the initial values (P = 0.02). The lower (lacrimal) lid punctum distance from the inner canthus preoperatively was 6.5 ± 0.3 mm and 7.4 ± 0.2 on day 1 post operatively, 7.2 ± 0.3 two weeks post operatively, 7.0 ± 0.4 mm at 3 months postoperatively (P = 0.04) [Table 1]. The MRD2 preoperatively was 5.0 ± 0.1 mm, 5.4 ± 0.1 mm at 1 days postoperatively, 5.2 ± 0.2 mm at 2 weeks, and 5.4 ± 0.3 mm at 3 months after surgery (P = 0.02).

: An increase in lower lid laxity was noted on distraction test & lacrimal lower punctum distance post cataract surgery. Although such a change is expected in the common cataract surgery age group, there seems to be a definite increment noted in the post surgery group.
Correlation of clinical parameters and objective assessment tools in active thyroid eye disease – Prospective analytical study
Authors: Karthik Senthil Kumar Niranjan , G Senthamarai , A Samarapuri
Published: May 2022

Primary objective of this study was to identify the disease in active phase, clinically assess it and start medical management. Secondary objective was to analyze whether the objective tools like B-scan and serum levels of IL-6 and HS-CRP aid in the diagnosis of activity in thyroid eye disease. 

: The aim wasto analyze the correlation of clinical parameters and significance of objective assessment tools in active thyroid eye disease. Clinically diagnosed cases of TED with lid signs, soft tissue changes, restrictive myopathy and bilateral axial proptosis were included in our study. Patients in chronic stable phase were excluded from study. This was a prospective analytical study, conducted from June 2010 till June 2012. Sample size was thirty patients in the age group of 20 to 60 years. Complete ophthalmology workup and objective disease assessment tools including B scan (OTI 1000 with 7.5-10 MHz) was used in our study. All patients underwent CT scan orbit-axial and coronal view. After assessing the severity and stage of the disease, each patient was managed accordingly using different modalities.

: Identifying the disease activity early and aggressive management with systemic steroids in moderately active and severe stage has decreased the morbidity associated with the disease. A- scan with orbital B-scan helps in diagnosing the activity in thyroid eye disease. This procedure is very economical with relatively short examination time and no risk of radiation .Follow up of the patients can also be performed easily. IL-6 and HS-CRP was statistically significantly elevated in patients with severe disease when compared to control group. Hence can help in assessing disease activity in patients with severe disease.
Late-onset retinoblastoma camouflaged with proven chronic uveitis: A case report
Authors: Ashok Kumar Dhivya , Thajudeen Heba
Published: May 2022

A rare case of a 16year old female, diagnosed elsewhere as chronic uveitis in the left eye positive antinuclear antibodies and Anti-SSA antibodies, treated with steroids and referred for cyclocryotherapy for a painful blind eye. On examination, the patient denied perception of light. There was proptosis, limitation of extraocular movements and corneal melting with no view of the posterior segment. Ultrasound B scan showed dense vitritis with doubtful specks of calcification. Magnetic resonance imaging revealed a soft tissue mass obliterating the vitreous and anterior chamber with retroscleral extension and involvement of the optic nerve. Extended enucleation was performed under General anaesthesia. Histopathological examination confirmed a well differentiated retinoblastoma with extrascleral and optic nerve involvement. Metastatic work up was normal. Intravenous Chemotherapy and post surgery radiotherapy to the socket was advised for further management. Late onset retinoblastoma mimicking ocular inflammation with positive antibody serology is rare and the report shows the need for imaging in refractory uveitis.
Sixth nerve palsy: Three case reports on different etiologies
Authors: Mehbub Ul Kadir Syeed , Md. Rajibul Islam Shah , Ashraf Shafiul , Ahmed Rezwan , Rabbani Golam , Md. Bulbul Islam Shah
Published: May 2022

Sixth nerve palsy is the commonest isolated cranial nerve palsy. Possessing the longest course, it is susceptible to damage through a myriad of etiologies, hence termed ‘false localizing sign’. Though frequently being a benign process with spontaneous recovery, it may be due to serious underlying pathology. Therefore, sixth nerve palsy requires careful clinical workup with tailored investigation. We are presenting three cases of isolated sixth nerve palsy having different etiologies.
¿Como reconstruir la educación postpandemia? Soluciones para cumplir con la promesa de un mejor futuro para la juventud
Authors: Abizanda Beatriz , Almeyda Gonzalo , Arias Ortiz Elena , Berlanga Cecilia , Bornacelly Iván , Bos María Soledad , Díaz Ela , Dueñas Ximena , Elacqua Gregory , Elías Alison , Fernández-Coto Raquel , Frisancho Verónica , García Moreno Vicente A. , Hernández Cardozo Jenny Carolina , Hincapie Diana , Margitic Juan Francisco , Mateo-Berganza Díaz María Mercedes , Morduchowicz Alejandro , Muñoz Felipe , Näslund-Hadley Emma , Ruiz-Arranz Marta , Thailinger Agustina , Valverde Rodríguez Francisco Javier , Vezza Evelyn , Zoido Pablo
Published: May 2022

Durante la pandemia de COVID-19, 165 millones de estudiantes de América Latina y el Caribe se vieron abruptamente desconectados de la educación. A finales de 2021, las escuelas habían estado cerradas una media de 237 días, más que en cualquier otra parte del mundo. Aunque la pandemia de COVID-19 ha afectado las vidas de mucha gente en todo el mundo, no lo ha hecho de manera uniforme. Tal vez uno de los legados más devastadores de la pandemia sea su efecto sobre los jóvenes. Durante uno de los periodos de desarrollo más críticos de la vida, un gran número de jóvenes se han visto privados de educación y expuestos a mayores niveles de inseguridad social, sanitaria, económica, violencia doméstica y abusos. A pesar de los esfuerzos de toda la comunidad educativa para garantizar que los estudiantes mantuvieran algún nivel de aprendizaje, las pruebas recogidas en este informe muestran que muchos escolares no participaron en actividades de aprendizaje significativas y que el parón en la acumulación de habilidades y capital humano tendrá consecuencias inmediatas y a largo plazo para el bienestar de los países. ¿Por qué? No fue sólo la pandemia. Fue el hecho de que la región y sus sistemas educativos no estaban bien preparados para soportar un choque de esta magnitud. Los efectos a corto y largo plazo de la crisis sanitaria no pueden entenderse si el relato no incluye las condiciones de partida. El objetivo de este informe es proporcionar a los responsables de la política educativa de toda la región una idea de la magnitud de los daños, sus consecuencias si no se toman medidas inmediatas, sustanciales y eficaces, y las prioridades de la política educativa teniendo en cuenta el punto de partida y los efectos de la pandemia. Y lo que es más importante, el informe también constituye una brújula para que el sector educativo desarrolle respuestas basadas en la evidencia dirigidas a las necesidades inmediatas de los jóvenes, así como las medidas a medio plazo que se necesitan para reconstruir nuestros sistemas educativos para que sean más resistentes, equitativos y eficientes a la hora de desarrollar estudiantes eficaces a lo largo de toda la vida. Si no hacemos nada, dejaremos atrás a toda una generación. Los gobiernos tienen que utilizar todas las palancas de las que dispongan para recuperarse, y la educación es clave en ese proceso.
Use of artificial refuges as a strategy for the conservation of bats
Authors: Vieda-Ortega Juan Camilo , Muñoz-Saba Yaneth Del Socorro , Giraud-López Marie Jöelle , Aguirre-Ceballos Jaime , Chaux-Rojas Daniel Felipe
Published: May 2022

One of the main problems for the conservation of bats in Colombia is ignorance about them and their ecosystem services. In this study, we aimed to contribute to the understanding and conservation of the bat fauna of the Pasuncha region (Pacho, Cundinamarca, Colombia) by making a species inventory, installing artificial shelters as a conservation strategy, and implementing education programs addressing human-bat interaction. We recorded eight species for the region: Artibeus lituratus, Carollia brevicaudum, Carollia castanea, Carollia perspicillata, Sturnira erythromos (fruit eaters); Glossophaga soricina (nectarivorous-polynivorous); Eptesicus brasliensis (insectivore), and Desmodus rotundus (sanguinivorous). We found C. brevicaudum, C. perspicillata, and G. soricina using abandoned houses as refuges and measured the basic population characteristics of the species at the Roble & Nogal reserve. Based on the biotic and abiotic information, we designed, built, and installed a bat box for fruit eaters and nectarivorous-polynivorous species. We also implemented an environmental education project focused on citizen science to encourage changes in the community’s perceptions and behavior toward bats whose results were reflected in a series of illustrative brochures produced jointly with the community.
ISO Standards as a Quality Assurance Mechanism in Higher Education
Authors: Vorobyova Oksana , Horokhova Maryna , Iliichuk Liubomyra , Tverezovska Nina , Drachuk Oleksandra , Artemchuk Liudmyla
Published: May 2022

This article examines and analyses the use of ISO international standards to assure the quality of higher education. It identifies the specifics of the ISO international quality management system in higher education. It makes a comparative analysis of basic principles of ESG, ISO 9001:2015 and ISO 21001 and determines that ISO 9001 standards are general in nature, they do not offer any specific model of the quality assurance management system and provide an organization with the freedom to create its own industry-specific quality assurance system meeting the requirements of the general management system. Therefore, these standards should be used to develop and establish the quality assurance system in higher education. It is stated that ISO 21001 Educational Organizations – Management Systems for Educational Organizations, specially developed for the educational industry, includes the methodological framework to create the effective management system for educational institutions and provides additional mechanisms for the ESG efficient implementation and development. The application of ISO standards in higher education will help improve the quality of rendered services, increase the competitive ability of higher education institutions and stimulate the development of innovative society in the global perspective.
Distance Education on the Basis of Innovative Technologies. Problems of the Primary School Teacher Training in Ukraine
Authors: Zaporozhchenko Tetiana , Fonariuk Olena , Popadych Olena , Kliuieva Snizhana , Ashikhmina Nataliia , Kanibolotska Olha
Published: May 2022

In the article, the authors analyze international experience of scientists, the Ukrainian realities and prospects for selection of expedient innovation tools. The purpose of such selection is to optimize distance education in the primary school teacher training in Ukraine on the basis of innovative technologies. The relevance of the topic is determined by a number of contradictions between the need for innovations in distance education and objective obstacles on the way to this. The purpose of the article is formulation of selection criteria, selection of the most urgent and most relevant accessible technologies and the theoretical substantiation of their application (on the example of teaching and learning the discipline “Mathematics”). The methodology involved includes the following methods: searching, sampling (according to relevance, effectiveness, regional features) and theoretical. Methods of modeling, generalization and forecasting were applied partly. The result of the work is substantiation of various types of innovative lectures as the best method of distance teaching and selection of specific technologies which (according to the didactic evidence) are the most effective. Also, the efficiency of the Moodle platform is described as the most universal access tool. Along with the literature review, fragments of discussion and comparison took place, which testified that the Ukrainian problem of innovative distance education belongs to the resource and psychological (stereotypes) area. International significance. The article is interesting for the reformers of education in developing countries and the scientists who follow the world tendencies in the education digitalization.
Professionally Oriented Tasks in the System of Professional Training of Musical Art Teachers
Authors: Sokolova Alla , Fomin Volodymyr , Tkachenko Maryna , Vasylieva Oksana , Parfentieva Iryna , Martynenko Ivan
Published: May 2022

The relevance of the chosen topic of the article is determined by the need of definition of the tasks in the system of professional training of musical art teachers, that are focused on work, as the integration of higher musical and pedagogical education of Ukraine in the world educational and cultural space based on the principles of national and ethno cultural interests, preservation and development of the Ukrainian intellectual potential of the nation, peacekeeping orientation of international cooperation, tolerance and adaptation in the assessment of mastering and achievements in the field of art culture of different nationalities, puts forward new requirements for the training of future musical art teachers (FMAT) in the field of higher education institutions (HEI).The article analyzes the theoretical developments on the topic, specifies the tasks in the system of vocational training of musical art teachers in the works of researchers and scientists, the experience of future musical teachers in higher educational institutions. These conditions include: ensuring the motivation of students to professionally solve educational problems by immersing FMAT in an innovative professional educational environment; application of innovative methods of design of educational activities of students in the process of studying the disciplines "Pedagogy", "Musical Pedagogy" to enrich the technical knowledge of the FMAT; to help students to realize the need for continuous professional self-improvement in the process of passing various types of educational practice. The implementation of a certain educational factor was aimed at forming a specific component of the phenomenon under study.
Interactive storytelling for the retelling of autobiographical memory in children: A social robotics approach
Authors: Ozaeta Leire , Perez Itsaso , Rekalde Itziar
Published: May 2022

Memory is one of our fundamental mental functions, which allows us to revive the past in our minds. When memory is mentioned, we usually want to refer to a particular kind of memory, which is autobiographical memory. Access to these memories can be altered by various affective disorders, especially depression. Regarding these techniques, this study aims to focus on storytelling to contribute to the resilience of children using a social robot approach, as they do not perceive the robot as a figure of superiority, but as a peer. The article follows a literature review method.  This paper presents a preliminary scenario for child-robot interaction in three phases, using interactive storytelling as a way to review the children's past experiences. To help those people, particularly children who have faced trauma, to remember the past in a structured and positive way, life review techniques have been developed.
Keywords: Autobiographical; memory; robotics; storytelling.
Advances in understanding the contribution of weeds to the functioning of agroecosystems
Authors:   Agroécologie, AgroSup Dijon, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, Dijon, France, Petit Sandrine , Yvoz Séverin ,   Agroécologie, AgroSup Dijon, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, Dijon, France, Ploteau Alexandre ,   Agroécologie, AgroSup Dijon, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, Dijon, France, Zuccolo Camille ,   Agroécologie, AgroSup Dijon, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, Dijon, France, Cordeau Stéphane ,   Agroécologie, AgroSup Dijon, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, Dijon, France
Published: May 2022

Reduction in herbicide use will trigger changes in weed communities. Improving our capacity to identify farming management options that will lead to weed communities offering interesting trade-offs of functions is thus timely. Functional approaches are offering a robust framework to quantify and understand the underlying mechanisms that link farming management to weed functions. This chapter reviews recent advances in our understanding of the role of weed diversity, of key weed functional traits and of their intraspecific variability in the functioning of the agroecosystem. It presents recent progress in the emerging field of weed multifunctionality assessment. While the scarce data available supports that some weed communities can deliver several beneficial functions without causing much crop yield loss, the challenge for the future will be to demonstrate that there are interesting weed functions trade-offs that can be achieved over a wide range of agronomic and weeds contexts, that are cost-effective and credible for farmers to adopt.
Advances in understanding invasive characteristics in weed species
Authors:   Çanakkale Onsekiz Mart University, Turkey, Uludağ Ahmet , Arslan Mehmet ,   Erciyes University, Turkey, Üremiş İlhan ,   Hatay Mustafa Kemal University, Turkey, Aksoy Necmi ,   Düzce University, Turkey
Published: May 2022

Genetic modifications are a well-known mechanism for understanding the evolution of weeds and invasive alien plants. Recently more attention has been given to epigenetic modifications in weed ecological genetics since epigenetic modifications can govern the ecological-adaptive potential of weed species. The chapter starts by discussing the role of genetic modifications before focusing on epigenetic modifications to illustrate the importance of epigenetics in understanding invasiveness and weediness.
Modelling the effects of cropping systems on weed dynamics: the trade-off between process analysis and decision support
Authors:   AgroSup Dijon, INRAE, Université de Bourgogne, France, Colbach Nathalie
Published: May 2022

Models are essential to synthesize knowledge on weeds and to design integrated weed-management strategies. These models must rank cropping systems as a function of weed infestation, and account for variability in effects to estimate probabilities of success or failure. Three case studies are presented: (1) an empirical static single-equation model that directly relates weed biomass to crop management, with few inputs and parameters, (2) a matrix-based multiannual model predicting a few key weed stages annually, from weed control options and a few parameters, (3) a mechanistic process-based multiannual model predicting detailed soil, crop and weed state variables daily, with an individual-based 3D canopy representation, requiring hundreds of inputs and parameters. The chapter concludes that models using a mechanistic representation of the cropping-system ´ environment interactions are best for quantifying effects and their variability, combined with a subsequent transformation with in silico experiments into empirical models of key cropping-system components.
Developing decision support systems (DSS) for weed management
Authors:   University of Patras, Greece, Kanatas Panagiotis , Travlos Ilias ,   Agricultural University of Athens, Greece, Gazoulis Ioannis ,   Agricultural University of Athens, Greece, Tataridas Alexandros ,   Agricultural University of Athens, Greece
Published: May 2022

The objectives of this chapter are to review what is achievable in DSS designed specifically for weed management, identify the obstacles in creating more effective DSS, and discuss how to increase adoption by farmers. DSS can model crop yield losses due to weed competition and set thresholds for intervention which can significantly reduce herbicide use. Developing DSSs able to prevent the spread of herbicide-resistant weeds is a challenging objective for experts and agronomists. Validated and reliable results as well as continuous communication between experts and farmers are key factors affecting adoption of DSS in weed management.
Advanced detection technologies for weed scouting
Authors:   Instituto de Ciencias Agrarias (CSIC), Spain, Fernandez-Quintanilla C. , Dorado J. ,   Instituto de Ciencias Agrarias (CSIC), Spain, Peña J. M. ,   Instituto de Ciencias Agrarias (CSIC), Spain, Andújar D. ,   Centro de Automatica y Robótica (CSIC), Spain
Published: May 2022

This chapter discusses advanced detection technologies for weed scouting. It starts by highlighting the current techniques that can be used to make optimising herbicide treatments more efficient, such as on-ground and remotely-sensed weed detection. The chapter then goes on to discuss the replacement of herbicide treatments for other control tactics. A section on redesigning farming systems to contribute to agroecosystem sustainability is also included, focusing specifically on collaborative research programs, agroecology, cropping systems and the impacts of control actions. The chapter concludes by highlighting the importance of improving detection technologies for weed scouting in the future.
Optimising integrated weed management in narrow-row crops
Authors:   ARVALIS-Institut du Végétal, France, Bonin L. , Leskovšek R. ,   Agricultural Institute of Slovenia, Slovenia, Moonen C. ,   Institute of Life Science, Italy, Smith W. ,   NIAB, UK, Sønderskov M. ,   Aarhus University, Denmark
Published: May 2022

Sustainable management of weeds represents a major challenge for farmers. Herbicides offer the most effective curative technique and are widely used. Nevertheless, less reliance on them is necessary for environmental and technical reasons, and also in the face of societal pressure. Four detailed case studies, from Denmark, United Kindom, France and Slovenia illustrate the effectiveness of combined methods to control weeds and preserve/improve farmers’ income.
Integrated weed management in grasslands
Authors:   CABI, Switzerland, Schaffner Urs , Müller-Schärer Heinz ,   University of Fribourg, Switzerland, Lüscher Andreas ,   Agroscope, Switzerland
Published: May 2022

This chapter describes the current status of IWM for grasslands. Its focus is on management practices available to influence transitions in a weed’s life cycle: from the soil seed bank to seedling establishment, from the seedling stage to the mature plant, and from the mature plant to the soil seed bank. We provide a conceptual approach to illustrate how management practices available in IWM affect different transitions and then discuss case studies to illustrate how weed management practices have been integrated. The chapter ends with an outlook for further improving IWM in grasslands, especially also under climate change, and for promoting its application.
Integrated weed management in perennial woody crops
Authors:   IAS-CSIC, Spain, Pedraza Verónica , González-Andújar José Luis ,   IAS-CSIC, Spain, Huet Victoire ,   NIAB EMR, UK, Tuteirihia Paul ,   NIAB EMR, UK, Lecourt Julien ,   Pôle Scientifique des vignobles Bernard Magrez, France
Published: May 2022

Perennial woody crops span over a broad variety of species in Europe with olive and vine being the most cultivated tree crops. Nowadays, the increasing problem of herbicide resistance, the possible withdrawal of herbicides from the EU market and their effects on farmland biodiversity are driving a need to change weed control practices. Therefore, a combination of different weed management techniques is commonly used with the main goal being to maintain productivity, maximise water and nutrients availability for the trees and reduce chemical weed control. Case studies from Spain and United Kingdom are presented where practices such as tillage, mulch application, no-till systems with herbicide use and spontaneous/sown cover crops are applied. However, the most suitable integrated weed management (IWM) strategy will be influenced by location, soil type, crop features, topography, farmer preferences and climatic conditions.
Evaluating the economics of integrated weed management
Authors:   Wageningen Plant Research, The Netherlands, de Wolf Pieter , Houben Saskia ,   Wageningen Plant Research, The Netherlands, Bijker William ,   Wageningen Plant Research, The Netherlands, Klompe Koen ,   Wageningen Plant Research, The Netherlands
Published: May 2022

Integrated weed management (IWM) contributes to the reduction of the use of pesticides and the risks of pesticide use. Novel IWM strategies can have economic consequences for farming systems. To develop alternative weed management strategies that maintain productivity while reducing the environmental impact of weed control for farms in a specific region, the cost effectiveness and feasibility of options should be made clear prior to implementation. In this chapter we discuss our approach for the pre-evaluation of the economics of novel IWM strategies in wheat production, comparing our method with other economic evaluation studies.
De Panificio, Narcissus e De Creatione
Authors: Gouvêa Júnior Márcio Meirelles
Published: May 2022

Este artigo apresenta uma proposta de tradução de três exemplares paradigmáticos dos centões latinos. No entanto, para análise mais acurada dessas obras específicas, e, por conseguinte, de todos os exemplares conhecidos da ars centonaria, uma técnica de composição poética ainda pouco estudada entre os lusófonos, buscou-se oferecer um estudo introdutório que não apenas detalhasse suas origens, mas que também fornecesse aos leitores subsídios para a decodificação da intertextualidade constituinte dos centões. Para tanto, foram aplicadas modernas teorias semióticas, em virtude das quais pode ser percebida e aproveitada a riqueza literária contida nesses poemas, resultado do intenso diálogo com a herança clássica que motivava a produção poética durante a Antiguidade tardia.
La investigación básica y el Premio Nobel de Química 2021
Authors: Gonzales Gustavo F.
Published: May 2022

El Premio Nobel de Química del 2021 fue otorgado a dos investigadores, Benjamín List de Alemania, y David W.C. MacMillan de Escocia, por el descubrimiento de una nueva forma de catálisis diferente al de las enzimas y de los metales, en la que utilizando moléculas simples pueden desarrollar de manera selectiva y a muy bajo costo productos que son de gran utilidad en la medicina. Esta nueva manera de catálisis se denomina “la biocatálisis orgánica asimétrica”. El trabajo de estos investigadores y sus grupos, uno en Europa y otro en Estados Unidos, nos muestra la importancia en la actualidad de la investigación básica y pura, y por lo tanto los gobiernos como el nuestro deberían apoyar este tipo de investigación.
A Review of Future Household Waste Management for Sustainable Environment in Malaysian Cities
Authors: Cheng Kin Meng , Tan Jia Yue , Wong Shen Yuong , Koo Ah Choo , Amir Sharji Elyna
Published: May 2022

In recent years, Malaysia has faced environmental challenges caused by municipal solid waste, especially household waste, during the Covid-19 pandemic. Among all the household waste, plastic and paper are the most prominent waste that causes environmental hazards. Several recycling associations in Malaysia have carried out their practices for better waste sustainability and management to curb the increasing amount of household waste. However, the effectiveness is still vague in achieving smart and effective household waste management. Therefore, this paper aims to investigate Malaysia’s household waste management, mainly in three significant municipalities in Malaysia for Kuala Lumpur, Penang and Melaka, in becoming a resilient and sustainable city by addressing two main research questions 1) What are the key factors for ensuring the more success move for future household waste management in cities? and 2) How will the 3 municipalities address their waste issues based on the key factors from RQ1, respectively? This paper reviewed 13 waste management articles and explores the potential of the four factors of waste management from the perspective of technology and data, economy, social and governance. The discussed factors and models contributed to an integrated future-proofing framework that focuses on smart waste tracking, an gamified awareness education, and strict policies to control waste management are the way forward for the future of smart cities household waste management.
ANTIMICROBIAL RESISTANCE AND MORTALITY
Authors: Hariyanto Hori , Quando Yahya Corry , Cucunawangsih Cucunawangsih , Pravita  Pertiwi Cecilia Lenny
Published: May 2022

Background : Antibiotic resistance has been a long - debated topic since decades ago. The development of stronger, newer antibiotics, implementation of antibiotic stewardship and revised guidelines remain t he main focus of our society to prevent resistancy. But is it really resistancy that cause higher mortality to patients with multidrug resistance (MDR) infections? Methods : We conducted a cohort retrospective study from 2016 to 2019 in our Intensive care u nit (ICU). Antimicrobial susceptibility test (AST) results were analyzed for their association with patient mortality outcomes. Results : Over the four - year period, 381 positive bacterial cultures were analyzed and 51% of them grew MDR pathogens upon their first culture. The overall mortality rate was 19% (38/195), and there was no significant association between MDR and mortality; p 0.387. A strong association was however found between patients with medical cases with an OR 1.76; CI 1.76 - 2.55; p 0.003 and t hose with APACHE scores ≥20 upon admittance to the ICU, OR 1.32; CI 1.68 - 8.29; p 0.001 . Conclusion : Resistancy is not the true cause of mortality. Infection by resistant microbes does not necessarily mean the worst outcome since virulency is the actual cau se of pathogenicity, and thus mortality