bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient multi-fidelity computation of blood coagulation under flow
Authors: Guerrero-Hurtado Manuel , Garcia-Villalba Manuel , Gonzalo Alejandro , Martinez-Legazpi Pablo , Kahn Andrew M. , McVeigh Elliot , Bermejo Javier , del Alamo Juan C. , Flores Oscar
Published: October 2023

Clot formation is a crucial process that prevents bleeding, but can lead to severe disorders when imbalanced. This process is regulated by the coagulation cascade, a biochemical network that controls the enzyme thrombin, which converts soluble fibrinogen into the fibrin fibers that constitute clots. Coagulation cascade models are typically complex and involve dozens of partial differential equations (PDEs) representing various chemical species’ transport, reaction kinetics, and diffusion. Solving these PDE systems computationally is challenging, due to their large size and multi-scale nature. We propose a multi-fidelity strategy to increase the efficiency of coagulation cascade simulations. Leveraging the slower dynamics of molecular diffusion, we transform the governing PDEs into ordinary differential equations (ODEs) representing the evolution of species concentrations versus blood residence time. We then Taylor-expand the ODE solution around the zero-diffusivity limit to obtain spatiotemporal maps of species concentrations in terms of the statistical moments of residence time, t R p ¯, and provide the governing PDEs for t R p ¯. This strategy replaces a high-fidelity system of N PDEs representing the coagulation cascade of N chemical species by N ODEs and p PDEs governing the residence time statistical moments. The multi-fidelity order (p) allows balancing accuracy and computational cost providing a speedup of over N/p compared to high-fidelity models. Moreover, this cost becomes independent of the number of chemical species in the large computational meshes typical of the arterial and cardiac chamber simulations. Using a coagulation network with N = 9 and an idealized aneurysm geometry with a pulsatile flow as a benchmark, we demonstrate favorable accuracy for low-order models of p = 1 and p = 2. The thrombin concentration in these models departs from the high-fidelity solution by under 20% (p = 1) and 2% (p = 2) after 20 cardiac cycles. These multi-fidelity models could enable new coagulation analyses in complex flow scenarios and extensive reaction networks. Furthermore, it could be generalized to advance our understanding of other reacting systems affected by flow.
Contemporary pathways to adolescent pregnancy in Indonesia: A qualitative investigation with adolescent girls in West Java and Central Sulawesi
Authors: Ayuandini Sherria , Habito Marie , Ellis Steven , Kennedy Elissa , Akiyama Maki , Binder Gerda , Nanwani Sandeep , Sitanggang Margaretha , Budiono Neira , Ramly Ali Aulia , Humphries-Waa Karen , Azzopardi Peter S. , Hennegan Julie
Published: October 2023

In the last decade, reduction in adolescent fertility rates in Indonesia has slowed despite national programmes and policies focused on addressing child marriage. Indonesia currently has the highest number of births to adolescent girls aged 15–19 years in Southeast Asia. There is a need to develop a more nuanced understanding of the drivers of adolescent pregnancy in Indonesia to inform programmes and policies tailored to young people’s needs and priorities. This study explored adolescent girls’ pathways to pregnancy across two provinces (Central Sulawesi and West Java) in Indonesia. We conducted participatory timeline interviews with 79 girls aged 15–21 years from urban, peri-urban, and rural communities and inquired about their relationships and life experiences leading up to pregnancy. We conducted follow-up interviews with 19 selected participants to validate and clarify preliminary findings. We identified six pathways to adolescent pregnancy which were broadly differentiated by the timing of pregnancy relative to marriage. Three pregnancy pathways within marriage were further differentiated by the main motivation for marriage–financial reasons, protecting the girl and family’s reputation, or to progress a romantic relationship. Three pregnancy pathways outside marriage were distinguished by the nature of the sexual relationship preceding pregnancy–consensual sex, unwanted or pressured sex, and forced sex. Drivers of adolescent pregnancy include the acceptability of child marriage and stigma surrounding premarital pregnancy, family and social expectations of pregnancy following marriage, harmful gender-based norms and violence, and lack of sexual and reproductive health information and access to services. Adolescents follow varied pathways to pregnancy in Indonesia. The idealisation and acceptance of child marriage is both a catalyst and outcome of adolescent pregnancy, which is occurring amid stigma surrounding premarital sex and pregnancy, harmful gender-based norms and violence, and barriers to contraceptive access and use. Our findings emphasise that there are many drivers of adolescent pregnancy and different pathways will require intervention approaches that address child marriage alongside other key contributors.
Proportion of paediatric admissions with any stage of noma at the Anka General Hospital, northwest Nigeria
Authors: Farley Elise , Karinja Miriam Njoki , Lawal Abdulhakeem Mohammed , Olaleye Michael , Muhammad Sadiya , Umar Maryam , Gaya Fatima Khalid , Mbaeri Shirley Chioma , Sherlock Mark , Kabila Deogracia Wa , Peters Miriam , Samuel Joseph , Maloba Guy , Usman Rabi , van der Kam Saskia , Ritmeijer Koert , Ariti Cono , Amirtharajah Mohana , Lenglet Annick , Falq Grégoire
Published: October 2023

Introduction

Noma is a rapidly spreading infection of the oral cavity which mainly affects young children. Without early treatment, it can have a high mortality rate. Simple gingivitis is a warning sign for noma, and acute necrotizing gingivitis is the first stage of noma. The epidemiology of noma is not well understood. We aimed to understand the prevalence of all stages of noma in hospitalised children.

Methods

We conducted a prospective observational study from 1st June to 24th October 2021, enrolling patients aged 0 to 12 years who were admitted to the Anka General Hospital, Zamfara, northwest Nigeria. Consenting parents/ guardians of participants were interviewed at admission. Participants had anthropometric and oral examinations at admission and discharge.

Findings

Of the 2346 patients, 58 (2.5%) were diagnosed with simple gingivitis and six (n = 0.3%) with acute necrotizing gingivitis upon admission. Of those admitted to the Inpatient Therapeutic Feeding Centre (ITFC), 3.4% (n = 37, CI 2.5–4.7%) were diagnosed with simple gingivitis upon admission compared to 1.7% of those not admitted to the ITFC (n = 21, CI 1.1–2.6%) (p = 0.008). Risk factors identified for having simple gingivitis included being aged over two years (2 to 6 yrs old, odds ratio (OR) 3.4, CI 1.77–6.5; 7 to 12 yrs OR 5.0, CI 1.7–14.6; p = <0.001), being admitted to the ITFC (OR 2.1; CI 1.22–3.62) and having oral health issues in the three months prior to the assessment (OR 18.75; CI 10.65, 33.01). All (n = 4/4) those aged six months to five years acute necrotizing gingivitis had chronic malnutrition.

Conclusion

Our study showed a small proportion of children admitted to the Anka General Hospital had simple or acute necrotizing gingivitis. Hospital admission with malnutrition was a risk factor for both simple and acute necrotizing gingivitis. The lack of access to and uptake of oral health care indicates a strong need for oral examinations to be included in routine health services. This provision could improve the oral status of the population and decrease the chance of patients developing noma.
Visuo-haptic processing of unfamiliar shapes: Comparing children and adults
Authors: AlAhmed Furat , Rau Anne , Wallraven Christian
Published: October 2023

The question of how our sensory perception abilities develop has been an active area of research, establishing trajectories of development from infancy that last well into late childhood and even adolescence. In this context, several studies have established changes in sensory processing of vision and touch around the age of 8 to 9 years. In this experiment, we explored the visual and haptic perceptual development of elementary school children of ages 6–11 in similarity-rating tasks of unfamiliar objects and compared their performance to adults. The participants were presented with parametrically-defined objects to be explored haptically and visually in separate groups for both children and adults. Our results showed that the raw similarity ratings of the children had more variability compared to adults. A detailed multidimensional scaling analysis revealed that the reconstructed perceptual space of the adult haptic group was significantly closer to the parameter space compared to the children group, whereas both groups’ visual perceptual space was similarly well reconstructed. Beyond this, however, we found no clear evidence for an age effect in either modality within the children group. These results suggest that haptic processing of unfamiliar, abstract shapes may continue to develop beyond the age of 11 years later into adolescence.
A new statistical approach for China road freight transport at a subnational level
Authors: Huang Fuyou , Wang Jianbo , Xie Wenying , Chen Bin , Ma Chao
Published: October 2023

Currently, there is a large deviation between official road freight data and real road freight performance at a subnational level in China. In order to deal with this deviation, the new concept of local freight tonnage and ton-kilometers is presented in this paper based on the territoriality principle, where either the origin or the destination of goods transported is local. Also, the statistic procedures and estimation models of the local freight tonnage and ton-kilometers are proposed based on five accessible basic datasets. Finally, an empirical study in Sichuan province of China is conducted. The statistical results show that there is a large amount of local freight transported by local non-commercial trucks and non-local trucks, which is ignored in the existing road freight statistics. Especially, the higher the level of local economic development, the greater the deviation between the official road freight data and the real road freight performance at a subnational level.
En casa. Huellas del habitar precario
Authors: Girola Claudia
Published: October 2023

Este artículo trata sobre los sentidos que dan hombres y mujeres en situación de calle —sometidos a una “urbanidad de los bordes” en diferentes comunas de la región parisina— a sus lugares de vida. Sentidos que emergen a partir de una serie de escenas y relatos etnográficos de prácticas del habitar y de sociabilidades compartidas por aquellas personas. Relatos de vidas activas que ponen en evidencia la violencia interpretativa y éticamente cuestionable, contenida en la ecuación aplicada para el análisis de las experiencias cotidianas de estas mismas personas, que establece una relación causal entre precariedad socioeconómica extrema e incapacidad de estar en el mundo. Ecuación que las reduce a seres desocializados, incapaces de construir un lugar propio, un chez-soi, donde preservar su intimidad, organizar su cotidiano y al mismo tiempo abrirse al otro en un gesto de hospitalidad y de intercambio. Estos relatos hablan de memorias y de casas, de experiencias, saberes y competencias que revelan, al contrario de la mirada desocializante, personas en una lucha obstinada para enfrentar, cada día, las determinaciones históricas y estructurales de su condición de vida extrema, lucha que las inscribe de una manera ineluctable y vital en el mundo social común.
Cuidado e identidad
Authors: Martín Palomo María Teresa , Paperman Patricia
Published: October 2023

En el texto se presenta una reflexión sobre la relación entre cuidado e identidad a partir de cuatro hilos de conversación que tensionan tanto la noción de identidad como la relación entre identidad y cuidado: a) pensar los procesos de categorización, el reconocimiento, la forma de nombrar, y quien toma la palabra; b) los usos de la noción de identidad en singular, considerada como una simplificación, y en plural, que complejiza la noción de identidad en especial si se toma en perspectiva temporal; c) la concepción de la identidad como una categoría antropomórfica que es cuestionada en perspectiva posthumanista; y, d) el poder que el Estado tiene de atribuir la identidad en tanto que pertenencia, de otorgar unos papeles para poder ser parte. En síntesis, para contribuir a la reflexión sobre la identidad sería interesante pensar en algunas de las propuestas de la discusión planteada, cómo salir de la mirada antropomórfica y atemporal de la identidad, o sobre el desafío de pensar la identidad cuando se trata de personas que no tienen una clara noción del sí mismo (ej. determinadas situaciones de diversidad funcional).
Tejer el nido. Los lazos sociales que hacen que una vivienda devenga casa
Authors: Merklen Denis
Published: October 2023

En discusión con la concepción de “la casa como un nido”, propuesta por Gastón Bachelard en su Poética del Espacio (1957), desde una perspectiva sociológica se propone una concepción de la casa a partir de su inserción en una trama de relaciones sociales de tres tipos diferentes: los de la familia, los del barrio y los de la sociedad, presentes estos últimos a través de la infraestructura de servicios urbanos. Se critica la concepción de propiedad privada de la vivienda y se contrasta la política de los gobiernos de izquierda de América latina y del Sur de Europa, con los sistemas de vivienda social de propiedad pública característicos de los países del Noroeste de Europa. A partir de una investigación de campo realizada en barrios populares en la ciudad de Lille, Francia, se discute la importancia de la higiene y de la relación entre lo privado, lo íntimo y lo social incluso como territorio de la militancia barrial.
Los corretiados y la casa prometida
Authors: Aguiar Sebastián , Montealegre Natalia , Rossal Marcelo
Published: October 2023

A partir de un proceso de interlocución con personas en situación de calle que se han conformado como organización social en Montevideo, el texto plantea pensar la casa desde la situación límite del que no la tiene. Para ello se distinguen tres momentos. Primero, la irrupción de personas en situación de calle en una sede universitaria, donde se conforma un colectivo, Nitep, Ni todo está perdido. Segundo, cómo esa organización durante la pandemia comienza a habitar un espacio que más tarde se convertiría en un dispositivo diurno para personas en situación de calle (“La Casa”) en base a un acuerdo entre la Universidad y el gobierno local. Finalmente, se detallan categorías relativas a estar en calle en la ciudad y la demanda por la vivienda de Nitep, que se profundiza, pero sin obtener más que promesas y respuestas parciales a un problema, el derecho a un nido, que es total, tanto para el colectivo como para cada uno de sus integrantes.
Desire satisfaction and its discontents
Authors: Farokhi Kakesh Hadis
Published: October 2023

According to a well-established view of desire satisfaction, a desire that p is satisfied iff p obtains. Call this the 'standard view'. The standard view is purely semantic, which means the satisfaction condition of desires is placed in the truth of the embedded proposition that indicates the content of the desire. This paper aims to defend the standard view against two frequently discussed problems: the problem of underspecification and desires conditional on their own persistence. The former holds that the standard view cannot capture the specific ways of desire satisfaction. The latter holds that the standard view does not provide sufficient conditions for the satisfaction of desires conditional on their own persistence. To address the first problem, I will disambiguate different interpretations of desire ascriptions using de re/de dicto distinction. My argument to address the second problem rests on the disambiguation of different senses of satisfaction: semantic and agent.
Technológiai változások érzékelése információs mintázatok mentén
Authors: Mátó Ágnes Réka , Vilmányi Márton
Published: October 2023

Kapcsolati kontextusban a változást a hálózati interakcióval írják
le. A változás kognitív és interaktív folyamat, melynek megragadása
érdekében az üzleti hálózati szakirodalom a hálózati kép fogalmát
definiálta. Tanulmányunkban azt vizsgáljuk, hogy a technológiai változás
hogyan módosítja a problémamegoldásban résztvevő aktorok hálózati képét.
Vizsgálatunk során dokumentumelemzés és szakértői interjúk segítségével
két, egymástól elkülönült egészségügyi ellátási folyamatot elemeztünk.
Elemezzük, hogy egy új technológia bevezetése kapcsán a tevékenységek és a
felhasznált erőforrások megváltozása milyen jellegű viszonyban áll az
információ elérhetőségének észlelt változásával. Eredményeink három
érzékelési mintázatra mutatnak rá, melyek a szervezeti változások további
megértéséhez járulhatnak hozzá.
Policy Directions for Securing Food Security by Applying Critical Infrastructure in the Field of Agriculture
Authors:   Crisis and Emergency Management: Theory and Praxis, Choi Junho , Cheung Chong Soo , Lee Dongkwan , Kwon Seol A , Lee Jae Eun
Published: October 2023

This study aims to suggest policy directions to promote food security by applying the concept of critical infrastructure in Korea. It designates the agricultural sector for food security through the functions, systems, and facilities of critical infrastructure and presents policy directions. The results of the analysis show that the functions of critical infrastructure can be implemented by establishing a food security manual. Due to the lack of relevant manuals in Korea, it is necessary to strengthen the response system on a regular basis through the designation of a department dedicated to food security and the task, rather than ad hoc measures. The s y stem o f critical infrastructure is a public stockpile. As in the c ase of J apan, Korea also n eeds to strengthen the public stockpiling system through public-private cooperation to maintain an appropriate stockpile. The critical infrastructure facility is a grain stockpile. It is also necessary for Korea to devise a comprehensive food complex by understanding the characteristics and economic feasibility of grains in the future.
An Analysis of the Effect of CPTPP on Japan's Export Using the Spatial Panel Gravity Model
Authors:   Crisis and Emergency Management: Theory and Praxis, Hwang Seong-hyuk , Kim Jongin
Published: October 2023

The purpose of this paper is to quantitatively measure the effect of the CPTPP on Japan's exports to member countries, and to find out various factors affecting Japan's exports. In this study, we adopt the spatial Durbin gravity model to consider the spatial dependency and spillover effects of trade flows between Japan and CPTPP member countries during the period from 2017 to 2021. While the CPTPP did not directly increase Japan's exports, it had an indirect spillover effect due to increased trade among other CPTPP member countries, which decreased Japan's exports. The factors that have a more direct impact on Japan's exports to CPTPP member countries are currently GDP of both countries, distance between countries, and the exchange rate. In particular, the direct effect of the exchange rate is most significant, as a depreciation of the Japanese yen enhances the price competitiveness of Japanese products, resulting in increased exports.
La educación. Una perspectiva integradora
Authors: Delgadillo-Cely Ingrid Sissy
Published: October 2023

El presente artículo constituye un ensayo reflexivo acerca de cómo la pandemia es solo una de las situaciones que debemos asumir frente a las exigencias que el cambio climático y la consecuente crisis ambiental nos demandan. Sostiene que desde la educación tenemos la responsabilidad de contribuir a enfrentar estos desafíos, promoviendo un viraje creativo, solidario, con apuestas epistémica y culturalmente diversas, hacia la renovación de la relación de la humanidad con lo existente desde una visión de integración y de conexión planetaria y espiritual.
Atributos del pensamiento tecnológico en estudiantes de tercero de primaria: El caso de una institución pública en Bogotá Colombia
Authors: Pérez-Jácome Cristian Camilo , Suárez Óscar Jardey
Published: October 2023

El objetivo de la investigación es establecer la incidencia en los atributos de pensamiento tecnológico de los estudiantes de tercer grado de un colegio público en Bogotá D.C., a través la implementación de dos actividades tecnológicas escolares, una con estrategia didáctica de construcción y otra con estrategia de análisis basado en ingeniería inversa. El enfoque metodológico es cuantitativo. El diseño metodológico es cuasiexperimental con tres grupos, a conveniencia (uno en cada intervención y otro con metodología habitual). Se utiliza el instrumento de atributos del pensamiento tecnológico para registrar las observaciones pre y pos. Los resultados muestran ganancia en los tres grupos; sin embargo, hay una mayor ganancia con menor dispersión, cuando se utilizan las actividades tecnológicas escolares. A manera de conclusión, la metodología favorece el pensamiento tecnológico del estudiantado, promoviendo la interacción colaborativa con artefactos tecnológicos, a través de actividades intencionadas en el contexto propio de la educación en tecnología.
Computer Modelling of Yarn Winding on Conical Bobbins
Authors: Dvorzhak Volodymyr , Rubanka Mykola , Rubanka Alla , Polishchuk Oleh
Published: October 2023

The article presents the results of the computer modelling of yarn winding on conical bobbins based on the analytical method of constructing tubular-shaped surfaces as a partial case of channel surfaces using the vector algebra apparatus. It is stated that the guide line takes the shape of a conical spiral line along which the forming moves (in the form of a circle with a diameter equal to the average diameter of the yarn), and is set using the moving Frenet basis. The obtained mathematical models facilitate the building, in MathCAD 3D visualization graphics, of a tubular-shaped surface, which represents the layers of yarn winding on a conical cartridge, and the reinforced yarn, which comprise the core component and the wrapping component, as well as the determination of both the lengths of individual layers of winding and the total length of winding (not including the transition sections). Well-known methods of forming geometric objects and computer modelling were also used in the work. The theoretical studies are based on the basic principles of textile production technology.
Favna kačjih pastirjev (Odonata) okolice Hotunj pri Ponikvi (vzhodna Slovenija)
Authors: Bedjanič Matjaž
Published: October 2023

A list of 35 species for the study area, observed between May and September 2022, is provided with complete faunistic data. Altogether, six species are listed on the national Red List, while the Ornate Bluet Coenagrion ornatum and the Balkan Goldenring Cordulegaster heros are protected and listed in the Annexes of the EU’s Habitat Directive. The records of the Blue-eye Erythromma lindenii, Green-eyed Hawker Aeshna isoceles and Blue Chaser Libellula fulva are also interesting from a faunistic point of view and are presented in the broader context of their distribution in Slovenia. At selected census transects along melioration ditches in the narrower study area north of Hotunje, 32 species were recorded. The dynamics of the number of recorded species during the season and the corresponding dynamics of the increase in cumulative number of recorded species are shown. A total of 37 odonate species are known so far for the relatively small area around Hotunje. Further faunistic research is needed for the wider area between Ponikva and Dramlje, as it remains poorly studied in terms of biodiversity and nature conservation importance.
Developing Tourism in Hoa Binh Province in the Context of International Economic Integration
Authors: Hien Tran Thi , Hoa Ho Thi , Hanh Nguyen Thi Hong , Hoa Nguyen Thi Minh , Thao Nguyen Thi Phuong
Published: October 2023

According to a report from the Department of Culture, Sports and Tourism, in the first 6 months of 2023, the total number of tourists coming to Hoa Binh is about 2,360,000, increasing by 28.8% compared to the same period last year, reaching 67.4% of the year plan. Of which, there were 240,000 international visitors, an increase of 336% compared to the same period last year, reaching 53.3% of the year's plan; 2,120,000 domestic visitors, an increase of 19.3% compared to the same period last year, reaching 69.5% of the year's plan. Total revenue from tourists reached 2,300 billion VND, an increase of 16.2% compared to the same period last year, reaching 59% of the year plan. The above impressive recovery results after the COVID-19 pandemic are thanks to the province's tourism industry having synchronously deployed many groups of tasks and solutions to develop destinations, building tours, and attractive tourism product groups and organize a variety of activities to attract the attention of domestic and foreign tourists, creating a premise for tourism to recover and maintain operations in the last months of the year and the following years. The article focuses on analyzing and evaluating the current status of Hoa Binh tourism development in the period 2018 - 2022 and proposes some solutions to promote the development of the province's tourism industry in the context of international economic integration.
Chemistry saving lives: using First World War Hypo helmets to avoid chlorine poisoning
Authors: Horikoshi Ryo , Yoshida Souma
Published: October 2023

A Hypo helmet is a fabric hood soaked with an aqueous solution of two sodium salts for the detoxication of chlorine that was developed during the First World War. Herein, we report on a lecture, developed for non-chemistry majors that used the Hypo helmet to highlight the physical and chemical properties of chlorine. The lecture consisted of the following three components: (1) a brief introduction to the First World War (the Chemists’ War), (2) video demonstrations of the generation of chlorine by mixing bleaching powder and hydrochloric acid and the detoxication of chlorine using a dummy Hypo helmet, and (3) students’ written impressions of the lecture. The students’ written impressions revealed two things: the lecture on chlorine and the Hypo helmet was well received, and most of the students (71 %, N = 82) did not know that chlorine was used as a poisonous gas during the First World War.
Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
Authors: Venditti Noemi , Petronio Giulio Petronio , Pinti Melania , Cutolo Giovanni , Pietrangelo Laura , Massini Laura , Magnifico Irene , Cutuli Marco Alfio , Petrone Federica , Papini Stefano , Di Marco Roberto , Corbi Graziamaria
Published: October 2023

The aim of this retrospective cohort study is to understand if and how much the preventive self-isolation approach might have been a valid model to avoid care-related infection, not only from COVID-19 but also from other non-viral infectious diseases. From March to May 2020, the healthcare and management staff of the Villa Santa Maria long-term care facilities, located in the village of Montenero di Bisaccia (Campobasso, Molise, Italy), decided to carry out a preventive self-isolation plan to safeguard the residents from SARS-CoV-2. The impact on other infectious diseases was evaluated by analyzing the antibiotic therapies prescription trend among the inpatients. Our data showed that although self-isolation protected residents and caregivers from SARS-CoV-2, it can also be associated with mobility reduction, leading to an increase in bedridden pathologies, namely, pressure ulcers and pressure sores. The simultaneous isolation of residents and caregivers in the same location significantly reduced any outside influence as a cause of possible infections.
Additive manufacturing of a lightweight Al-Ca alloy by direct energy deposition and laser powder bed fusion
Authors: Preußner J. , Rödler G. , Fischer F. G. , Hintz K. , Friedmann V. , Weisheit A.
Published: October 2023

High strength and low density materials are needed to achieve lightweight design of components. Aluminum base metals alloyed with calcium are of potential interest because of the low density of calcium and its abundance. The additive manufacturing of dense and crack free samples out of an Al-10 wt.% Ca (Al-10Ca) alloy is presented. Both laser-based direct energy deposition (DED-LB) and laser powder bed fusion (LPBF) processes were applied to manufacture sample material. Preheating of the substrate plate is needed in LPBF to receive crack free samples. An analysis of the microstructure shows an Al-Al4Ca lamellar eutectic.
A novel near-infrared fluorescent probe for cysteine and application in bioimaging
Authors: Gu Xin , Chen Jiajia , Yang Xindi , Zhou Wei , Yang Li
Published: October 2023

Cysteine (Cys) plays key roles in various pathological and physiological processes. Thus, the specific detection of Cys is a great necessity for the related disease diagnosis. Herein, we present a novel fluorescent probe based on a 2-benzothiazolyl-6-quinazolinyl-4-methylphenol moiety as fluorophore and a 2,4-dinitrobenzenesulfonyl moiety as detection functioned group. The probe presented a rapid and specific turn on response to Cys under physiological conditions, which could be convenient observed by the naked eyes. The detection mechanism was elucidated by HRMS, UV/vis absorption, fluorescence and DFT calculation. Furthermore, the probe was applied to monitor the endogenous Cys in living cells and mice.
Közösségi tanulás a settlement mozgalomban és a Szegedi Fiatalok Művészeti Kollégiumában
Authors: T. Molnár Gizella
Published: October 2023

A közösségi tanulás és az intergenerációs tanulás az LLL olyan új, modern eszközeiként jelennek meg az utóbbi évtizedekben a neveléstudományi, andragógiai szakirodalomban, amelyek segítenek a 21. század kihívásaira választ adni. Alaposabban megvizsgálva azonban kitűnik, hogy a kultúra és az ismeretközvetítés történetében régóta találkozhatunk ezekkel, és az egyetemes kultúrtörténet is azt mutatja, hogy mindig különösen nagy jelentőséggel bírnak azon időszakokban, amikor a társadalom új kihívásokkal szembesül. A tanulmány amellett érvel, hogy a settlement mozgalmat a modern közösségi tanulás előképeként határozhatjuk meg. A settlement a 19. század végén Angliából indulva Európa számos országában, majd Magyarországon is megjelent, mások mellett a húszas évek végén a szegedi egyetem hallgatói körében. A hazai settlement történetét elsősorban a képviselőiktől való primer források, korabeli szövegek és kiadványok alapján vázoljuk fel röviden azzal a meggyőződéssel, hogy segítségükkel sikerül érzékeltetni a settlementben zajló közösségi tanulási formákat és generációs kölcsönhatásokat, valamint ezek társadalmi hasznát. Kiemelt figyelmet szentelünk a szegedi egyetemhez is kapcsolódó agrársettlement mozgalomnak, a Bethlen Gábor Kör és a belőle kifejlődő Szegedi Fiatalok Művészeti Kollégiuma örökségének. A szövegek tanulmányozása során azon meggyőződésünket igyekszünk validálni, hogy van mire alapozni a múlt értékeiből napjainkban, amikor a közösségi tanulásról és a generációk közötti interakciókról, kölcsönös tanulási kapcsolatokról gondolkodunk.
Rethinking Maritime Education and Training for Generation Z Students
Authors: Bartusevičienė Inga , Kitada Momoko , Valionienė Elena
Published: October 2023

Every country’s economy depends on workforce competencies that are developed mostly by education systems, in which institutions of higher education play an important role. With the spread of higher education and the continuous development of opportunities for lifelong learning, higher education institutions are facing challenges organising education by addressing the needs and preferences of different generations. As research shows, different generations have various learning preferences, needs and goals in life, and education. To organise teaching and learning activities effectively (now and in the future), educational institutions need to understand the characteristics of the multi-generational student population, and the tendencies in future changes to the student population. This is important for many industries, including the maritime industry. To supply young talent to the maritime industry, maritime education and training also need to take into account the future workforce and the needs of industry, in terms of new challenges, such as technological changes, sustainability goals, decarbonisation, and the blue economy. This paper presents an analysis of the changes in the student population at the World Maritime University higher education institution over the last five years, with a special focus on Generation Z. Insights into the organisation of effective education to address the needs of the maritime industry are presented based on the tendencies identified.
A Study on the Fishing of Ulleungdo and Dokdo by Jeju Haenyeo
Authors:   Institute of Korean Cultural Studies Yeungnam University, Kim Kyoung do , Kwon Mi seon
Published: October 2023

Due to the damages caused by Japan's underwater fishing industry, the fishing grounds of Jeju Island were devastated. Starting from 1895, Jeju Haenyeo (women divers) began migrating to locations such as Busan and Ulsan for fishing. During the period of Japanese colonial rule, their fishing activities extended to regions including China, Japan, and other areas. After Korea's liberation, the Haenyeo continued their fishing endeavors around Ulleungdo and Dokdo, with those fishing around Dokdo contributing to strengthening effective control over the island. It is necessary to examine the fishing practices of Jeju Haenyeo in Ulleungdo and Dokdo, as the management systems of these fishing grounds experienced significant changes before and after the Japanese colonial period.
After Korea's liberation, Ulleungdo fishermen actively utilized the fishing grounds to diversify their catches like squid, mackerel, and Alaska pollock. They also worked to increase their income through the cooperative use of village fishing grounds. However, concerning Dokdo, it had been a territory actively sought by Japan for colonization since the 17th century, leading to ongoing intrusions and military interventions even after liberation. The situation around Dokdo began to stabilize after the establishment of the Korean Dokdo Coast Guard unit, enabling Ulleungdo fishermen to utilize the island more securely. Particularly, over about 23 years of Dokdo fishing ground development and residency efforts led by Choi Jong-Deok, fishing practices on Dokdo started to exhibit differences from those in Ulleungdo, a distinction that was also reflected in the activities of the Haenyeo.
These changes in the management systems of Ulleungdo and Dokdo fishing grounds had an impact on the fishing practices of Jeju Haenyeo. Specialization in fishing techniques led to the evolution of fishing methods and alterations in fishing gear. These changes even influenced the terms of employment contracts for the Haenyeo. Ultimately, the cooperative village fishing practices of Jeju Haenyeo complemented the economic endeavors of both Ulleungdo fishermen and Jeju Haenyeo, contributing to income generation for both groups. Moreover, the utilization of Dokdo fishing grounds also contributed to strengthening South Korea's territorial sovereignty through effective governance.
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability
Authors: Burigotto Matteo , Vigorito Vincenza , Gliech Colin , Mattivi Alessia , Ghetti Sabrina , Bisio Alessandra , Lolli Graziano , Holland Andrew J , Fava Luca L
Published: October 2023

53BP1 acts at the crossroads between DNA repair and p53‐mediated stress response. With its interactors p53 and USP28, it is part of the mitotic surveillance (or mitotic stopwatch) pathway (MSP), a sensor that monitors the duration of cell division, promoting p53‐dependent cell cycle arrest when a critical time threshold is surpassed. Here, we show that Polo‐like kinase 1 (PLK1) activity is essential for the time‐dependent release of 53BP1 from kinetochores. PLK1 inhibition, which leads to 53BP1 persistence at kinetochores, prevents cytosolic 53BP1 association with p53 and results in a blunted MSP. Strikingly, the identification of CENP‐F as the kinetochore docking partner of 53BP1 enabled us to show that measurement of mitotic timing by the MSP does not take place at kinetochores, as perturbing CENP‐F‐53BP1 binding had no measurable impact on the MSP. Taken together, we propose that PLK1 supports the MSP by generating a cytosolic pool of 53BP1 and that an unknown cytosolic mechanism enables the measurement of mitotic duration.
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease
Authors: Schiano Guglielmo , Lake Jennifer , Mariniello Marta , Schaeffer Céline , Harvent Marianne , Rampoldi Luca , Olinger Eric , Devuyst Olivier
Published: October 2023

Missense mutations in the uromodulin (UMOD) gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD), one of the most common monogenic kidney diseases. The unknown impact of the allelic and gene dosage effects and fate of mutant uromodulin leaves open the gap between postulated gain‐of‐function mutations, end‐organ damage and disease progression in ADTKD. Based on two prevalent missense UMOD mutations with divergent disease progression, we generated UmodC171Y and UmodR186S knock‐in mice that showed strong allelic and gene dosage effects on uromodulin aggregates and activation of ER stress and unfolded protein and immune responses, leading to variable kidney damage. Deletion of the wild‐type Umod allele in heterozygous UmodR186S mice increased the formation of uromodulin aggregates and ER stress. Studies in kidney tubular cells confirmed differences in uromodulin aggregates, with activation of mutation‐specific quality control and clearance mechanisms. Enhancement of autophagy by starvation and mTORC1 inhibition decreased uromodulin aggregates. These studies substantiate the role of toxic aggregates as driving progression of ADTKD‐UMOD, relevant for therapeutic strategies to improve clearance of mutant uromodulin.
Evaluating E. coli genome‐scale metabolic model accuracy with high‐throughput mutant fitness data
Authors: Bernstein David B , Akkas Batu , Price Morgan N , Arkin Adam P
Published: October 2023

The Escherichia coli genome‐scale metabolic model (GEM) is an exemplar systems biology model for the simulation of cellular metabolism. Experimental validation of model predictions is essential to pinpoint uncertainty and ensure continued development of accurate models. Here, we quantified the accuracy of four subsequent E. coli GEMs using published mutant fitness data across thousands of genes and 25 different carbon sources. This evaluation demonstrated the utility of the area under a precision–recall curve relative to alternative accuracy metrics. An analysis of errors in the latest (iML1515) model identified several vitamins/cofactors that are likely available to mutants despite being absent from the experimental growth medium and highlighted isoenzyme gene‐protein‐reaction mapping as a key source of inaccurate predictions. A machine learning approach further identified metabolic fluxes through hydrogen ion exchange and specific central metabolism branch points as important determinants of model accuracy. This work outlines improved practices for the assessment of GEM accuracy with high‐throughput mutant fitness data and highlights promising areas for future model refinement in E. coli and beyond.
A bright future for glucagon and alpha cell biology
Authors: Panzer Julia K , Caicedo Alejandro
Published: October 2023

Long lagging behind insulin, glucagon research has caught up in large part, thanks to technological breakthroughs. Here we review how the field was propelled by the development of novel techniques and approaches. The glucagon radioimmunoassay and islet isolation are methods that now seem trivial, but for decades they were crucial in defining the biology of the pancreatic alpha cell and the role of glucagon in glucose homeostasis. More recently, mouse models have become the main workhorse of this research effort, if not of biomedical research in general. The mouse model allowed detailed mechanistic studies that are revealing alpha cell functions beyond its canonical glucoregulatory role. A recent profusion of gene expression and transcription regulation studies is providing new vistas into what constitutes alpha cell identity. In particular, the combination of transcriptomic techniques with functional recordings promises to move molecular guesswork into real-time physiology. The challenge right now is not to get enamored with these powerful techniques and to make sure that the research continues to be transformative and paradigm shifting. We should imagine a future in which the biology of the alpha cell will be studied at single-cell resolution, non-invasively, and in real time in the human body.
Grand Bahama Post-Hurricane Dorian
Authors: Welsh-Unwala Kristen , Imig Anne , Listl Isabella , Rein Arno
Published: October 2023

Freshwater lenses, a layer of fresh water that floats atop saline groundwater, are vulnerable sources of drinking water for small islands. The threats to freshwater lenses, and their recovery following catastrophic events, is not well documented. Due to storm surge and flooding during the Category 5 Hurricane Dorian in September 2019, the freshwater lenses of Grand Bahama were inundated with salt water, removing the freshwater source of drinking water for the island. This study builds on previous work to monitor the recovery of the freshwater lenses three years after the hurricane by assessing tidal lag, as well as stable isotopes in water (δ2H and δ18O), to understand the hydrologic characteristics of the FWL in Grand Bahama. Results from electrical conductivity revealed that the tidal lag, or the time it takes for the tidal effect to be observed in groundwater, was approximately 2.5 hours on average. Through stable isotope analysis of precipitation samples, we determined a local meteoric water line of δ2H = 8.2 * δ18O + 12.2, which is close to the global meteoric water line. Groundwater samples did not show evidence of significant evaporation from precipitation. These results serve as baseline data for additional monitoring and recovery efforts on Grand Bahama.
Asymptotic analysis of optimal control problems on the semiaxes for Carathéodory differential inclusions with fast oscillating coefficients
Authors: Dashkovskiy Sergey , Kapustyan Oleksiy , Kapustian Olena , Zhuk Tetyana
Published: October 2023

We consider an optimal control problem for a differential inclusion of the Carathéodory type affine with respect to the control with a coercive cost functional on a semiaxis and with fast oscillating time-dependent coefficients. We prove that, when the small parameter converges to zero, the solution to this problem tends to some solution of the optimal control problem with averaged coefficients, where the averaging we understand in the sense of the Kuratowski upper limit.
Prešić-type fixed point results via Q-distance on quasimetric space and application to (p, q)-difference equations
Authors: Altun Ishak , Gençtürk İlker , Erduran Ali
Published: October 2023

In this paper, we introduce two new properties to the Q-function, called as the 0-property and the small self-distance property, which is frequently used in studies of fixed point theory in quasimetric spaces. Then, with the help of Q-functions having these properties, we present some fixed point theorems for Prešić-type mappings in quasimetric spaces. Finally, we state a theorem for the existence and uniqueness of the solution to a boundary value problem for (p, q)-difference equations to demonstrate the applicability of our theoretical results, which we support with an example.
The Impact of Green Human Resource Management Practices on Organisational Performance
Authors: Alegbesogie Amenaghawon Igbinigiesu
Published: October 2023

GHRM integrates environmentally friendly principles into human resource policies and strategies, positively impacting the environment and organisational outcomes. By adopting GHRM practices, organisations can enhance their reputation, attract and retain top talent, and increase employee engagement. Initiatives such as eco-friendly recruitment processes, training programs on sustainability, and green employee benefits contribute to a positive organisational culture focused on environmental stewardship. Furthermore, GHRM practices promote resource efficiency, waste reduction, and eco-innovation within the organisation. These efforts result in cost savings, improved operational efficiency, and increased competitiveness. GHRM also facilitates compliance with environmental regulations and reduces the risk of legal and reputational damage. Ultimately, the implementation of GHRM practices leads to improved organisational performance by aligning environmental goals with strategic objectives, fostering employee commitment, and gaining a competitive advantage in the marketplace. Embracing sustainable HR practices is essential for organisations seeking long-term success in the context of environmental challenges and changing societal expectations.
Big Data Application for Traffic Estimation on a Website: Big Daddy Case
Authors: Udairaj Singh Shubham , Banelienė Rūta
Published: October 2023

While living under rapidly changing conditions innovation, flexibility and readiness to change are grounding prosperity of the firm. But any changes for companies should be reasoned and made on the basis of analytical approach. Big data usually could help in this situation without spending time and money on expensive research activities. Therefore, this paper is focused on big data application on customers’ behavior switching from one product to new its look. Modeling is based on few monthsˈ daily data with application of regression analysis and the least squares method. The major finding comes up with the estimation output that the new webpage is more popular among IOS and WEB users, although Android systems showing negative impact on switching to new website
A collection of scholarly articles: In the Fields of Applied Linguistics
Authors: Hilbig Inga , Jakaitė-Bulbukienė Kristina , Žurauskaitė Eglė , Daraškienė Inga
Published: October 2023

This collection of articles in applied linguistics is dedicated to Prof. Meilutė Ramonienė‘s anniversary. The book is compiled of papers written by her students, colleagues, and friends from Lithuania, Latvia, Estonia, and Switzerland. These texts are from various fields and subfields of applied linguistics, i.e., family language policy, national language policy, linguistic attitudes, motivation to learn a second language, linguadidactics, text linguistics, and linguistic impoliteness. In the preface, a short overview of Prof. M. Ramonienė‘s academic path and her as personality is given, and there is one more non-academic text that presents and highlights her long lasting fruitful contribution to the networking of the Baltic scholars.
Evangelizadores com Espírito em Comunidades Eclesiais Missionárias
Authors: De Fraga Gomes Tiago , Catelan Ferreira Antonio Luiz , Ribolli Fachin Patrícia
Published: October 2023

A presente pesquisa busca apresentar elementos para a ação evangelizadora da Igreja em Comunidades Eclesiais Missionárias à luz da pneumatologia do Papa Francisco, a fim de contribuir para o enfrentamento da ruptura geracional na transmissão da fé. Pretende-se refletir sobre a relevância de fomentar evangelizadores que vivam a santidade no Espírito e encarnada, inspirados na recepção do Concílio Vaticano II, nas exortações apostólicas Evangelli Gaudium e Gaudete et Exsultate do Papa Francisco e nas Diretrizes Gerais da Ação Evangelizadora da Igreja do Brasil propostas pela Conferência Nacional dos Bispos do Brasil para 2019-2023, as quais vigoram até 2025. Pretende-se culminar com uma reflexão sobre os desafios que o tema da sinodalidade propõe para a vida da Igreja atual.