bluuebunny/crossref_metadata_2025 huggingface dataset:
A semana da tuberculose de 1937 em Curitiba: educação para combater a enfermidade na terra dos “bons ares”
Authors: De Oliveira Marinice Sant’Ana , Bertucci Liane Maria
Published: November 2017

O artigo analisa como se deu a educação para combate da tuberculose na cidade de Curitiba (Paraná) durante a Semana da Tuberculose, realizada em novembro de 1937. O evento organizado por autoridades médico-governamentais mobilizou vários médicos, sendo realizadas palestras, distribuição de folheto educativo e utilização de jornais e da rádio local como difusores de informações. A Revista Médica do Paraná transcreveu algumas das palestras e publicou informações sobre o evento. Não havendo ainda medicamentos específicos para tratamento e cura da tuberculose, as recomendações baseavam-se na importância da higiene (individual e do ambiente), de uma alimentação adequada e uma vida “sem excessos” como formas de prevenção da doença. O tratamento dos tuberculosos apregoado pelos médicos se sustentava quase que exclusivamente no regime higiênico-dietético e no isolamento, visto como imprescindível para evitar novos contágios e para aumentar as possibilidades de cura.
A Gripe sob a ótica da História Ecológica: um estudo comparativo entre as pandemias de 1918 e 2009
Authors: Klajman Charles
Published: November 2017

Os autores que escreveram sobre a História Ecológica, relataram o dramático impacto das doenças infecciosas e o papel fundamental no desaparecimento de algumas civilizações dos novos mundos. Através dessa chave, utilizada por William McNeill em Plagues and Peoples (1998), Alfred Crosby em Imperialismo Ecológico (1993) e por Jared Diamond em Armas Germes e Aço (2001), pretendo apresentar um estudo comparativo entre a Gripe Espanhola de 1918 e Gripe Influenza A de 2009, vulgo Suína provocada pelo vírus H1N1, na formatação teórico-metodológica estabelecida por esses autores.
A saúde em tempos de desenvolvimento: a campanha de erradicação da malária na Amazônia
Authors: Andrade Rômulo De Paula
Published: November 2017

Nas décadas de 1950 e 1960, uma descoberta feita pelo médico Mario Pinotti ganhou vulto no Brasil e no mundo: a mistura de um antimalárico (cloroquina) ao sal de cozinha, dando origem ao chamado sal cloroquinado. O método de controle e erradicação da malária foi pensado e aplicado em uma região na qual a doença era (e ainda é) endêmica: a Amazônia. O artigo trata de três momentos específicos: as pesquisas iniciais que legitimaram a aplicação do produto em larga escala; a Campanha de Erradicação de Malária na região amazônica e, por fim, o ocaso do chamado sal medicamentoso como ferramenta de controle da doença. Por meio da articulação entre ciência, saúde e desenvolvimento, pretende-se aqui compreender este período da história da Amazônia.
ANÁLISE DA TRANSFERÊNCIA DE CONHECIMENTOS ADQUIRIDOS EM UM PROGRAMA DE TREINAMENTO EM ALVENARIA ESTRUTURAL
Authors: Bressiani Lucia , Oliveira Ana Maria de Sousa Santana de , Oliveira Ricardo Rocha de
Published: November 2017

RESUMO:  A transferência de aprendizagem é um dos processos de maior interesse nos modelos de avaliação de treinamento. Muitos trabalhos buscam investigar após o treinamento, quais eventos do ambiente de trabalho influenciam na eficácia do programa, contribuindo para a transferência de conhecimentos. Desta forma, este trabalho busca efetuar uma análise da transferência dos conhecimentos, após a realização de um treinamento em uma obra em alvenaria estrutural. O objetivo é verificar quais fatores afetam de forma positiva ou negativa na transferência de conhecimentos. Para o trabalho foi utilizado um modelo de avaliação de transferência já testado e validado por outros pesquisadores. O modelo foi aplicado para os funcionários envolvidos com o processo de execução das paredes em alvenaria estrutural em uma obra na cidade de Toledo, PR. Com isso, procura-se contribuir para a melhoria dos processos de treinamentos no setor da construção civil, de forma a se obter os melhores resultados em termos de desempenho no trabalho.ABSTRACT: The transfer of learning is one of the processes of greatest interest in models of training evaluation. Many studies seek to investigate after training, what events influence the effectiveness of the program, contributing to the transfer of knowledge. Thus, this work aims to make an analysis of the transfer of knowledge, after the completion of training in a work in masonry. The goal is to determine which factors affect positively or negatively the transfer of knowledge. For the study we used a transfer valuation model already tried and tested by other researchers. The model was applied to the staff involved in the implementation process of the walls in masonry in a work in the city of Toledo, PR. It seeks to contribute to the improvement of training processes in the construction sector in order to obtain the best results in terms of job performance.
Influence of social networks on the purchase decisions of university students
Authors:   Department of Organization Engineering. Carrera 80 No 65-223. Postal code: 050034.(Colombia). legutierrezf@ unal.edu.co, Gutiérrez Flórez Lorena Estefania , Correa Escobar Maria Isabel ,   Department of Organization Engineering. Carrera 80 No 65-223. Postal code: 050034.(Colombia). maicorreaes@unal.edu.co, Henao Restrepo Andrés ,   Department of Organization Engineering. Carrera 80 No 65-223. Postal code: 050034.(Colombia). anhenaore@unal.edu.co, Arango Botero Diana ,   Departament of Management Sciences. Carrera 31 No 54-10. Postal code: 050013 (Colombia). dianaarangob@ itm.edu.co, Valencia Arias Alejandro ,   Departament of Management Sciences. Carrera 31 No 54-10. Postal code: 050013 (Colombia). jhoanyvalencia@itm.edu.co
Published: November 2017

Departament of Management Sciences. Carrera 31 No 54-10. Postal code: 050013 (Colombia). dianaarangob@ itm.edu.co; jhoanyvalencia@itm.edu.co
The abilities of managers in UK pension funds. Are socially responsible managers superior?
Authors:   Facultad de Economía y Empresa, C/Gran Vía, 2, C.P.50005, Zaragoza (España). malda@unizar.es, Alda Mercedes
Published: November 2017

The abilities of managers in pension funds and, especially, in Socially Responsible (SR) pension funds have only rarely been investigated. Both standard pension funds and specialized SR funds are concerned with social welfare, but SR pension funds present a special interest of study. Various works show that SR managers usually underperform conventional funds because they focus on social aspects, although other studies find that SR funds overperform. In this work, the stock-picking and style timing abilities of UK conventional and SR equity pension fund managers are studied, examining whether SR pension funds implement different strategies and contribute to developing more socially responsible outcomes. Additionally, the influence of SR as a risk factor is introduced. As far as is known, style timing and the introduction of the SR risk factor have not been previously studied in the context of SR pension funds. The results indicate that both kinds of pension fund develop similar investment strategies, investing in small cap and growth values. Moreover, both funds present negative performance, poor/negative stock-picking abilities, and perverse market timing abilities. SR managers exhibit superior style timing skills and are able to correctly time size and book-to-market strategies. The SR risk factor shows that SR pension funds have significantly positive loadings of this factor, which erodes their performance. Overall, none of the funds analyzed develop proper management, and the optimization of the risk-return binomial in SR funds may be constrained by SRI requirements.
Determinants of Dividends Payout and Policy Used In Emerging Economies: Evidence from Turkey
Authors: Kisava Zakayo Samson , John Fredynandy M
Published: November 2017

The study is focused on the determinants of dividends payout and policy in the emerging economies, as the sector is too significant and gets more attention from large number of researchers in financial area as well as accounting because of its contribution in the economy. The scope of the study went throughout 2005 to 2016 years, the selected time was theoretically analyzed and studied to understand determinant of dividends payout and policy used in emerging economies in comparison to countries with emerged economy. The study used Turkey to represent emerging economies since it is among the fast growing economy despite political and economic issues it goes through. The study theoretically confirmed that size level, profitability size, retained earnings, net income, and debt level are the determinants of dividends payout and policy and are some of the significant factors. Additionally, through these factors we identified that emerging economies use unstable policies in comparison to developed economies. This study is too significant to investors since it will assist them to understand features of financial markets and companies listed or trading in those financial markets. Furthermore, the paper will assist financial managers to comprehend the significance of factors such as net income, cash balance, retained earnings and companies’ profitability in the process of dividend payments whilst maintaining stable financial position of the business.
Incidence and quantitative analysis of dissociated optic nerve fiber layer appearance: real loss of retinal nerve fiber layer?
Authors: Kim Yoon J. , Lee Kyoung S. , Joe Soo G. , Kim June-Gone
Published: November 2017

Purpose:

To assess the association between appearance of dissociated optic nerve fiber layer (DONFL) after internal limiting membrane (ILM) peeling and changes in the macular nerve fiber layer (NFL) area by spectral-domain optical coherence tomography (SD-OCT).

Methods:

This study included 132 consecutive patients who had successfully undergone vitrectomy with ILM peeling for idiopathic epiretinal membrane or macular holes and had been followed up for ≥6 months. Two examiners evaluated macular 5-line raster horizontal SD-OCT images and categorized the patients on the basis of presence (group I) or absence (group II) of DONFL. The average macular NFL areas in both groups were measured using ImageJ at baseline and 1, 3, and 6 months after surgery.

Results:

Among the 132 eyes of 132 patients, DONFL was noted in 42 (31.8%), 104 (78.8%), 106 (80.3%), and 106 (80.3%) eyes at 1, 3, and 6 months and at the last visit (12.8 ± 6.5 months) after surgery. These layers appeared most commonly between 1 and 3 months after ILM peeling. There was no significant difference in average macular NFL area between groups I and II (3453.4 ± 125.3 and 3513.0 ± 100.2 pixels, respectively) at 6 months after surgery (p = 0.56).

Conclusions:

Appearance of DONFL increased between postoperative months 1 and 3. Moreover, there was no significant difference in average NFL in terms of DONFL. Thus, appearance of DONFL might represent macular NFL rearrangement and reorganization rather than true mechanical damage to the NFL after ILM peeling.
Blindness and visual impairment in opera
Authors: Aydin Pinar , Ritch Robert , O’Dwyer John
Published: November 2017

Purpose:

The performing arts mirror the human condition. This study sought to analyze the reasons for inclusion of visually impaired characters in opera, the cause of the blindness or near blindness, and the dramatic purpose of the blindness in the storyline.

Methods:

We reviewed operas from the 18th century to 2010 and included all characters with ocular problems. We classified the cause of each character’s ocular problem (organic, nonorganic, and other) in relation to the thematic setting of the opera: biblical and mythical, blind beggars or blind musicians, historical (real or fictional characters), and contemporary or futuristic.

Results:

Cases of blindness in 55 characters (2 as a choir) from 38 operas were detected over 3 centuries of repertoire: 11 had trauma-related visual impairment, 5 had congenital blindness, 18 had visual impairment of unknown cause, 9 had psychogenic or malingering blindness, and 12 were symbolic or miracle-related. One opera featured an ophthalmologist curing a patient.

Conclusions:

The research illustrates that visual impairment was frequently used as an artistic device to enhance the intent and situate an opera in its time.
An unusual case of bilateral pigmented maculopathy and anterior segment dysgenesis
Authors: Bloch Edward , Pefkianaki Maria , Hakim Jamil
Published: November 2017

Purpose:

Pigmentary maculopathy can occur in the context of various inherited and acquired diseases. Anterior segment dysgenesis arises due to developmental anomalies and may be associated with systemic disease, as in Rieger syndrome.

Case report:

A 49-year-old woman presented with longstanding reduction in vision, evidence of anterior segment dysgenesis, and multiple discrete pigmented lesions throughout the macula bilaterally. Electroretinographic findings were consistent with severe macular dysfunction. Gene array analysis did not reveal any chromosomal imbalances or other specific abnormalities.

Conclusions:

This is a unique case of bilateral pigmentary maculopathy and anterior segment dysgenesis, with clinical findings that are not characteristic of previously reported disease.
Blue Planet dialysis: novel water-sparing strategies for reducing dialysate flow
Authors: Molano-Triviño Alejandra , Wancjer Benjamin , Neri Mauro M. , Karopadi Akash N. , Rosner Mitchell , Ronco Claudio
Published: November 2017

Introduction:

Hemodialysis (HD) is an expensive therapy in economic and in ecological terms, owing to a high carbon footprint and significant consumption of natural sources, especially water. Our aim was to review strategies to diminish waste of water in maintenance dialysis, exploring previously described water reuse trends and less known strategies for reducing the dialysate flow.

Methods:

We conducted a systematic review of water-sparing strategies, including the reuse of reverse osmosis rejected water and the reduction of dialysate flux. We performed a search in Medline, Pubmed, Scielo, OVID and Biblioteca Redentor, using key words: Dialysate flow rate, Dialysate flux, and decrease; excluding: online, peritoneal, continuous, blood access, needle, hemodiafiltration, acute, pharmacokinetics, increase. We limited our search to adult humans or in vitro trials in English, Spanish, Italian and Portuguese, between January 1980 and June 2017. We found 816 trials. 37 articles were retrieved for review, and 11 articles were analyzed.

Results and conclusions:

Conservation of water in chronic HD should be considered an important responsibility of healthcare practitioners all over the world. We present a wider usage of dialysate flow rates, considering that it would lead to significant water conservation without much compromise on dialysis efficacy in small patients. We believe that further investigation into the utility of reduced dialysate flux in different populations is needed to broaden our understanding of how we can use these techniques in order to significantly reduce water consumption during chronic HD while still ensuring optimum efficacy and efficiency of the therapy.
Printability of papers recycled from toner and inkjet-printed papers after deinking and recycling processes
Authors: Karademir Arif , Aydemir Cem , Tutak Dogan , Aravamuthan Raja
Published: November 2017

Background:

In our contemporary world, while part of the fibers used in the paper industry is obtained from primary fibers such as wood and agricultural plants, the rest is obtained from secondary fibers from waste papers. To manufacture paper with high optical quality from fibers of recycled waste papers, these papers require deinking and bleaching of fibers at desired levels. High efficiency in removal of ink from paper mass during recycling, and hence deinkability, are especially crucial for the optical and printability quality of the ultimate manufactured paper.

Methods:

In the present study, deinkability and printability performance of digitally printed paper with toner or inkjet ink were compared for the postrecycling product. To that end, opaque 80 g/m2 office paper was digitally printed under standard printing conditions with laser toner or inkjet ink; then these sheets of paper were deinked by a deinking process based on the INGEDE method 11 p. After the deinking operation, the optical properties of the obtained recycled handsheets were compared with unprinted (reference) paper. Then the recycled paper was printed on once again under the same conditions as before with inkjet and laser printers, to monitor and measure printing color change before and after recycling, and differences in color universe.

Results:

Recycling and printing performances of water-based inkjet and toner-based laser printed paper were obtained. The outcomes for laser-printed recycled paper were better than those for inkjet-printed recycled paper.

Conclusions:

Compared for luminosity Y, brightness, CIE a* and CIE b* values, paper recycled from laser-printed paper exhibited higher value than paper recycled from inkjet-printed paper.
Targeting zero catheter-related bloodstream infections in pediatric intensive care unit: a retrospective matched case-control study
Authors: Biasucci Daniele G. , Pittiruti Mauro , Taddei Alessandra , Picconi Enzo , Pizza Alessandro , Celentano Davide , Piastra Marco , Scoppettuolo Giancarlo , Conti Giorgio
Published: November 2017

Introduction:

The aim of this study was to evaluate the effectiveness and safety of a new three-component ‘bundle’ for insertion and management of centrally inserted central catheters (CICCs), designed to minimize catheter-related bloodstream infections (CRBSIs) in critically ill children.

Methods:

Our ‘bundle’ has three components: insertion, management, and education. Insertion and management recommendations include: skin antisepsis with 2% chlorhexidine; maximal barrier precautions; ultrasound-guided venipuncture; tunneling of the catheter when a long indwelling time is expected; glue on the exit site; sutureless securement; use of transparent dressing; chlorhexidine sponge dressing on the 7th day; neutral displacement needle-free connectors. All CICCs were inserted by appropriately trained physicians proficient in a standardized simulation training program.

Results:

We compared CRBSI rate per 1000 catheters-days of CICCs inserted before adoption of our new bundle with that of CICCs inserted after implementation of the bundle. CICCs inserted after adoption of the bundle remained in place for a mean of 2.2 days longer than those inserted before. We found a drop in CRBSI rate to 10%, from 15 per 1000 catheters-days to 1.5.

Conclusions:

Our data suggest that a bundle aimed at minimizing CR-BSI in critically ill children should incorporate four practices: (1) ultrasound guidance, which minimizes contamination by reducing the number of attempts and possible break-down of aseptic technique; (2) tunneling the catheter to obtain exit site in the infra-clavicular area with reduced bacterial colonization; (3) glue, which seals and protects the exit site; (4) simulation-based education of the staff.
How to treat arteriovenous graft infection: total versus partial graft excision
Authors: Min Kim Suh , Min Seung-Kee , Ahn Sanghyun , Min Sang-Il , Ha Jongwon , Chung Jung Kee
Published: November 2017

Introduction:

Arteriovenous graft (AVG) infection can result in life-threatening sepsis and loss of vascular access. A retrospective study was performed to establish an appropriate treatment strategy for AVG infection.

Methods:

A total of 50 cases of AVG infection were treated between January 2005 and June 2016. The surgical methods used were total graft excision (TGE) (n = 34), or partial graft excision (PGE) with interposition graft (n = 16).

Results:

Infection was noted at a puncture site (n = 22), a prior incision for surgery or endovascular therapy (n = 20), and abandoned (currently unused) grafts (n = 5). Infection occurred within 1 month after AVG creation (n = 1), or any intervention (n = 14), and more than 1 month after creation or intervention (n = 35). Simultaneous remote infection was identified in 7 patients, 2 of whom underwent an operation for infective endocarditis and spondylitis. After PGE, 5 patients (5/16, 31.2%) having recurrent infection were treated with further graft excision; however, no patient showed life-threatening complications. After TGE, a central venous catheter (CVC) was inserted and used for a median period of 90 days. Among 34 patients who underwent TGE, new vascular access was created in 18 patients at a median period of 2 months later, and 12 patients continued to use a CVC until last follow-up or death.

Conclusions:

PGE could be a treatment option for AVG infection to achieve both infection eradication and vascular access preservation in selected patients. Because of a higher risk of recurrent infection, sufficient surgical removal and careful postoperative management are warranted.
Intraspinal Mesenchymal Chondrosarcoma: Report of a Pediatric Case and Literature Review
Authors: Di Giannatale Angela , Colletti Marta , Russo Ida , Ferruzzi Valentina , Anna Vito Andrea Dell , Cozza Raffaele , Colafati Giovanna Stefania , Messina Raffaella , Mastronuzzi Angela , De Vito Rita , Milano Giuseppe Maria
Published: November 2017

Purpose

Mesenchymal chondrosarcoma (MCS) is an aggressive variant of chondrosarcoma and is a rare tumor, particularly within the pediatric population. Commonly, MCS originates in the bone, but it can also arise in extraskeletal sites, such as the brain and the intraspinal area. Due to the rarity of this tumor, there are no guidelines for its optimal treatment.

Methods

We report a case of intradural extra medullary MCS, located at the T11–T12 level, in a 14-year-old male. The tumor was documented by magnetic resonance imaging and treated with gross total resection (GTR) without adjuvant treatment. We further reviewed the relevant pediatric literature and discussed the management and outcome of intracranial and intraspinal MCS.

Results

The patient's follow-up showed no evidence of disease 2 years from diagnosis. A total of 51 cases of intracranial and intraspinal MCS have been reported (24 intraspinal and 27 intracranial). Recurrence has been described in only 4 patients with intraspinal MSC, and among them 3 received adjuvant chemotherapy and radiotherapy. GTR seems to reduce the risk of recurrence and, due to a higher cancer-mortality rate for these patients, adjuvant chemotherapy and radiotherapy are recommended in case aggressive surgery is not possible.

Conclusions

According to our single experience, we would suggest that adjuvant therapy might be unnecessary in cases where a localized MCS undergoes GTR. Chemotherapy and radiotherapy should be recommended when GTR cannot be obtained. Further studies are needed to investigate a standard treatment approach for this rare tumor.
FISIOLOGIA DA EREÇÃO PENIANA: UMA BREVE REVISÃO
Authors: SARRIS Andrey Biff , NAKAMURA Maki Caroline , STAICHAK Rodrigo Luiz , FERNANDES Luiz Gustavo Rachid , PUPULIM Alisson Ferreira , SOBREIRO Bernardo Passos
Published: November 2017

A ereção peniana é um processo neurovascular complexo que se inicia pela estimulação sexual através de fenômenos físicos e/ou psicológicos, mediado por substâncias que atuam no endotélio vascular para garantir um ato sexual satisfatório. O objetivo do artigo foi realizar uma revisão bibliográfica sobre os processos de ereção e detumescência peniana. Foi realizada pesquisa nas bases de dados “PUBMED”, “SCIELO” e “LILACS” e selecionados os artigos adequados à temática. Três são os fenômenos responsáveis pela ereção peniana: relaxamento dos músculos lisos, aumento do influxo sanguíneo arterial do pênis e restrição do fluxo sanguíneo venoso do pênis. Esses eventos levam à progressiva distensão dos espaços sinusoidais e à compressão do plexo venoso subtúnico contra a túnica albugínea. Já a detumescência ocorre com o relaxamento do músculo isquiocavernoso em consequência da contração do músculo liso cavernoso. Todos esses processos são controlados por inervação autônoma e somática. O sistema somatossensorial se origina em receptores na pele, corpo e glande do pênis e uretra e dão origem ao nervo pudendo. As estruturas nervosas são responsáveis por três tipos de ereção: psicogênica, ativada por estimulação audiovisual e fantasias; reflexogênica ativada por estimulação física da área genital; noturna com fisiopatologia ainda incompreendida. O principal neurotransmissor da ereção peniana é a acetilcolina, que estimula o endotélio a liberar oxido nítrico, responsável pelo relaxamento dos vasos sanguíneos; enquanto que o principal neurotransmissor da detumescência é a noradrenalina, responsável por vasoconstrição. Concluiu-se que a fisiologia da ereção é a base para o desenvolvimento de terapias a doenças prejudiciais à função sexual.
INCONTINÊNCIA URINÁRIA EM MULHERES: BREVE REVISÃO DE FISIOPATOLOGIA, AVALIAÇÃO E TRATAMENTO
Authors: CÂNDIDO Fernando José Leopoldino Fernandes , MATNEI Thiago , GALVÃO Letícia Carollyne , SANTOS Vamilly Leal de Jesus , SANTOS Melina Chaves dos , SARRIS Andrey Bif , SOBREIRO Bernardo Passos
Published: November 2017

A incontinência urinária (IU) é definida como qualquer perda involuntária de urina que gere desconforto social ou higiênico para a paciente e possa ser objetivamente demonstrado. Estudos indicam que até 40% das mulheres americanas tem algum grau de IU. Para que os pacientes mantenham uma capacidade adequada de continência urinária, é necessário que diversos músculos, nervos simpáticos, parassimpáticos e somáticos atuem conjunta e harmonicamente, sendo que a falha de qualquer uma dessas estruturas pode culminar na perda involuntária de urina. Considerando-se os distintos mecanismos fisiopatológicos e as diferentes clínicas possíveis da IU, ela pode ser subdividida em cinco tipos básicos: a incontinência de esforço, de urgência, mista, paradoxal ou contínua. Esse distúrbio é mais comumente encontrado em mulheres caucasianas e com história familiar positiva, o que demonstra a participação de fatores hereditários em sua etiologia. Dentre os fatores de risco ambientais, podemos citar: idade avançada, prática de atividades físicas de alto impacto, grande paridade, obesidade, tabagismo e presença de algumas doenças crônicas, como diabetes mellitus. De forma geral, os episódios de incontinência são responsáveis por grande constrangimento social das pacientes acometidas, podendo comprometer suas vidas na esfera social, psicológica, física e econômica. Ainda assim, muitas pacientes não compreendem a IU como uma doença e acreditam que se trate apenas de uma complicação natural do ato de envelhecer. Isso é preocupante, pois mascara a real gravidade do problema e faz com que a IU seja subestimada e negligenciada por muitos profissionais de saúde. Nas últimas décadas, diversos tratamentos conservadores foram propostos, como terapias farmacológicas, utilização de exercícios específicos, biofeedback e estimulação elétrica ou magnética. Apesar disso, a cirurgia ainda é considerada o principal método terapêutico para muitas das pacientes acometidas pela IU.
Korovkin Approximation Theorem with Ω Striped
Authors: Al-Muhja Malik Saad , Mursaleen Mohammad , Misiran Masnita , B. Omar Zurni , Yang Khoo Sui
Published: November 2017

In this paper, we discuss some theorem reached M. Mursaleen, there are several properties of statistical lacunary summability presented (Mursaleen, M. & Alotaibi,A., 2011; Mursaleen, M. &Alotaibi, A., 2011; Edely, O. H. & Mursaleen, M., 2009). This is concerned the motivate to narrowly delineated context denoted by Ω striped usage in prove our theorem (theorem A). We introduce some piecewise polynomial functions (Kopotun,K. A., 2006) and some results Korovkin theorem.
Reverse Definite Integral of Algebraic Functions
Authors: Mahat Yogesh
Published: November 2017

In this work, an algebraic function is considered and integrated the function with some particular boundaries to obtain the area. Through the help of the area obtained and given boundaries, we determined different functions of different degree. Also, found a relationship between them.
Empowerment Community Leaders as to Strengthen the Implementation of Regional Autonomy
Authors: Rachmi Handayani I Gusti Ayu Ketut , Marpaung Lintje Anna , Hamzah Guntur , Yuliandri Yuliandri , Mashdurohatun Anis
Published: November 2017

The local government together with community leaders consisting of traditional leaders, religious leaders, and NGOs need to work together in building the region so that it can thrive again and be able to strengthen the character of Indonesian society, in a society that increasingly modern and multicultural. With the cooperation, areas that initially the potential for conflict, it can be prevented by approaches are persuasive by the community leaders, to be more tolerant and try to take advantage or learn from the conflict. The principles of cooperation between local government and community leaders in strengthening regional autonomy in general that good governance principles that can be used as a guide in conducting cooperation between community leaders with local.
Identifying patients for palliative care in primary care in Brazil: Project Estar ao Seu Lado’s experience
Authors: Corrêa Santiago Rodríguez , Mazuko Carla , Mitchell Geoffrey , Pastrana Tania , De Lima Liliana , Murray Scott
Published: November 2017

Objective: To present the process of identification of palliative care patients in a Family Health Strategy´s team in Brazil. Methods: The identification process ocurred 1) using the system of work of a Family Health Strategy Team and the principles of primary care and 2) by applying the SPICT, a tool to help identify patients who might benefit with palliative care. Results: Twenty-three patients were enrolled in the palliative care program at the beginning of the project. By the end of the 12 month period, we had identified 38 patients. Six patients died during the time period. Thus during 2015, 38 people were identified with palliative needs from a total population of 3,000 (1.2% of the practice population). Of these 58% (n=22) were women, 63% (n=24) over 65 years, 74.7% (n=28) reported white ethnicity. The most frequent major diagnoses were cancer (39.5%), psychiatric disease (18.4%), cardiovascular disease (15.8%), frailty (10.5%), dementia (10.5%), and respiratory disease (7.9%). Multimorbity was higher in patients over 65 years (t-test, p=0.009) with a median of four diseases. The most prevalent conditions among those suffering multimorbidity were cardiovascular disease (73.7%), psychiatric disease (65.8%), cancer (50%), frailty (39.5%), diabetes mellitus (31.6%), and respiratory diseases (23.7%). Conclusion: We applied a tool for identifying patients who would benefit from palliative care in primary care in a community of Rio Grande. It was practical and feasible. Its further refinement, implementation and evaluation in Brazil is indicated at community centres of Family Health Strategy, specifically taking account of social and economic factors.
Infecções comunitárias do trato urinário em Divinópolis, MG: avaliação do perfil de resistência bacteriana e do manejo clínico
Authors: Ferreira Vanessa Machado , Rossiter Lucas Nicolas Viana , Aragão Nicole Faraje Ferreira , Pinto Otávio Augusto , Santos Paola Mara , Cardoso Pedro Henrique Alves , Cerqueira Thaís Braga , Fernandino Débora Moura , Rocha Gustavo Machado
Published: November 2017

Objetivo: Analisar o perfil de resistência bacteriana e o manejo clínico das infecções do trato urinário (ITU) no município de Divinópolis, MG. Métodos: Trata-se de estudo transversal descritivo, cujos dados foram obtidos a partir das uroculturas positivas realizadas no primeiro semestre de 2015 no Laboratório Municipal de Microbiologia e por meio de entrevistas com médicos atuantes na atenção básica de Divinópolis, MG. Resultados: Das uroculturas avaliadas (N=802), 72,8% isolaram a bactéria Escherichia coli, sendo 38,6% delas resistentes ao sulfametoxazol+trimetoprima, 33,0% ao norfloxacino, 31,8% ao ciprofloxacino e 9,0% à nitrofurantoína. Dos 57 médicos entrevistados, 73,5% solicitam, habitualmente, algum exame laboratorial para cistite aguda não complicada. Os antimicrobianos de primeira escolha no tratamento empírico das ITU, segundo os entrevistados, foram norfloxacino (56,1%), sulfametoxazol+trimetoprima (19,3%), ciprofloxacino (10,5%) e nitrofurantoína (8,8%). Conclusão: Os dados encontrados indicam que as taxas de resistência bacteriana às quinolonas nas ITU são elevadas e que a terapia empírica adotada pela maioria dos médicos entrevistados vai contra esse perfil de resistência. Por outro lado, foi encontrada uma baixa resistência à nitrofurantoína, demonstrando a necessidade de elaboração de protocolo local de tratamento.
Nanotechnology in the Water Industry, Part 2: Toxicology and Analysis
Authors: Bhattacharyya Sanjib , Bennett Jack , Short Luke C. , Theisen Tamara S. , Wichman Michael D. , White Jason C. , Wright Sarah
Published: November 2017

Nanotechnology and water treatment is a new, emerging pairing that requires examining the opportunities as well as the risks.
Getting to Know Your Stakeholders in Advance of a Rate Change
Authors: Davis Marci , Elliott Melissa Essex , Snyder Karen
Published: November 2017

While often considered to fall on the “softer side” of the water profession, effective customer and stakeholder communication is founded on data, qualitative and quantitative research, and strategic thinking, just like any other water planning effort. This is particularly true when lack of community understanding about or support of investment can stop all other utility activities midstream, which is the case for communication associated with cost of service and rate modifications.
Risk Communication
Authors: Mercer Kenneth L.
Published: November 2017

Although the literature on risk communication is extensive, the topic remains especially rich for the constantly evolving water industry. Risk communication is about conveying the possibilities of both bad and good outcomes, and there are numerous opportunities where potential risks and customer and community interests commix around water works. From public health protection to environmental stewardship, members of the water sector should appreciate that their work ultimately comes down to understanding and minimizing risks.
Innovation in the planning of V-Y rotation advancement flaps: A template for flap design
Authors: Dölen Utku Can , Koçer Uğur
Published: November 2017

Local flaps exhibit excellent color matching that no other type of flap can compete with. Moreover, surgery using a local flap is easier and faster than surgery using a distant or free flap. However, local flaps can be much more difficult to design. We designed 2 templates to plan a V-Y rotation advancement flap. The template for a unilateral V-Y rotation advancement flap was used on the face (n=5), anterior tibia (n=1), posterior axilla (n=1), ischium (n=1), and trochanter (n=2). The template for a bilateral flap was used on the sacrum (n=8), arm (n=1), and anterior tibia (n=1). The causes of the defects were meningocele (n=3), a decubitus ulcer (n=5), pilonidal sinus (n=3), and skin tumor excision (n=10). The meningocele patients were younger than 8 days. The mean age of the adult patients was 50.4 years (range, 19–80 years). All the donor areas of the flaps were closed primarily. None of the patients experienced wound dehiscence or partial/total flap necrosis. The templates guided surgeons regarding the length and the placement of the incision for a V-Y rotation advancement flap according to the size of the wound. In addition, they could be used for the training of residents.
Nicholas R. Brown. For the Nation: Jesus, the Restoration of Israel and Articulating a Christian Ethic of Territorial Governance
Authors: Leighton Christopher M.
Published: November 2017

No abstract is available.
ФОКУС НА ЗАДОВОЉСТВО КОРИСНИКА У ИНТЕГРИСАНОМ МЕНАЏМЕНТУ КРОЗ ПРИМЈЕНУ БСЦ КОНЦЕПТА У ГРАДСКОЈ УПРАВИ БАЊА ЛУКА // CUSTOMER SATISFACTION FOCUS IN INTEGRATED MANAGEMENT APPLIED THROUGH BSC CONCEPT IN ADMINISTRATIVE SERVICE IN LOCAL GOVERNMENT OF BANJA LUKA
Authors: Бобрек Мацановић Кристина
Published: November 2017

Задовољан корисник је основни приоритет како профитно оријентисанихкомпанија, тако и непрофиних организација или појединаца који се баве билокаквом испоруком производа или услуга. Глобални процеси у европској исвјетској економији афирмишу поступке мјерења задовољства корисника ипримјену многих метода менаџмента у вођењу организација према његовомсталном расту. Међутим, често у пракси није лако направити мост између визијекоју има главни менаџмент, преко оперативних циљева и стратегије којуспроводи оперативни менаџмент, па до запослених који су у свакодневномконтакту са корисником. У овом смислу значајну помоћ менаџментуорганизација пружају процеси стандардизације менаџмента који истовременопредстављају својеврсне облике глобализације на свјетском (ИСО стандарди) иевропском (ЕН норме) простору. Ови стандарди афирмишу примјенумногобројних метода и алата менаџмента који помажу организацијама далокална ограничења претварају у глобалне предности. Један од концепата којије веома успјешан управо у овој конкретизацији циљева и мјерењу њиховогостваривања је BSC - Balanced scorecard. Због тога је и циљ овог рада да покажепримјену концепта Balanced scorecard, у оквиру интегрисаног система менаџмента, са посебним акцентом на задовољство корисника. Конкретанпримјер ће бити приказан кроз BSC карту Градске управе Бањалука.
REFORMOM JAVNE UPRAVE I IMPLEMENTACIJOM SISTEMA KVALITETA DO BOLJE USLUGE U REPUBLICI SRPSKOJ // PUBLIC ADMINISTRATION REFORMS AND IMPLEMENTATION OF QUALITY SYSTEMS IN ORDER TO IMPROVE SERVICES IN REPUBLIC OF SRPSKA
Authors: Mrda Ljubomir , Radivojević Mladen
Published: November 2017

U sadašnjem načinu rada i poslovanja raste potreba i zahtjevi korisnika usluga zaboljom, bržom, jeftinijom, ali i drugačijom uslugom. Povećavaju se zahtjevi zaosiguranjem raspoloživosti, povjerljivosti i cjelovitosti informacija, koje se pojavljujuu najrazličitijim oblicima. Sveobuhvatne, a neizbježne promjene koje očekujuRepubliku Srpsku (Bosnu i Hercegovinu) u narednom periodu, prije svega uključujupromjene načina rada javne uprave. Novi trendovi, novi načini privređivanja,uslovljavaju drugačije potrebe korisnika javnih usluga. Javni sektor se mora otvoritiuticaju tržišta i u svoj rad integrisati metode rada privatnog sektora. Prihvatajućiosnovnu koncepciju kvaliteta i odnoseći se prema građanima i ostalim korisnicimasvojih usluga na drugačiji način, rad javne uprave mora biti bolji, brži i jeftiniji.Naglasak u ovom radu je dat na implementaciju kvaliteta koji može da obezbijedizadovoljstvo korisnika usluga i svih građana kao i njihov partnerski odnos doefikasnije i kvalitetnije usluge. U ovom radu, neophodnu promjenu prema kvalitetu iefikasnijem, a jeftinijem radu jedne uprave posmatramo u segmentu reforme javne uprave, boljeg usluživanja, te jeftinijem radu uz implemantaciju standarda kvaliteta iposlovne inteligencije. Posmatramo iskustva nekih zemalja, njihov sistemreformisanja javne uprave, njihova dostignuća, njihova pozitivna iskustva da bismo ihpokušali prilagoditi našim uslovima, našem radu i poimanju reforme i efikasnijegusluživanja. Pratimo CAF alate, sistem implementacije ISO standarda i kvaliteta ujavnu upravu, sve sa ciljem da predložimo nove modele koji reformu javne uprave uRepublici Srpskoj (Bosni i Hercegovini) mogu učiniti ostvarivom na zadovoljstvo idavaoca i korisnika usluga. Sagledavamo neke od dokazanih metodologijaimplementacije standarda i dajemo preporuke kako to ostvariti na ovim prostorima.
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis
Authors: Xian Xunde , Ding Yinyuan , Dieckmann Marco , Zhou Li , Plattner Florian , Liu Mingxia , Parks John S , Hammer Robert E , Boucher Philippe , Tsai Shirling , Herz Joachim
Published: November 2017

Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor with diverse physiological roles, ranging from cellular uptake of lipoproteins and other cargo by endocytosis to sensor of the extracellular environment and integrator of a wide range of signaling mechanisms. As a chylomicron remnant receptor, LRP1 controls systemic lipid metabolism in concert with the LDL receptor in the liver, whereas in smooth muscle cells (SMC) LRP1 functions as a co-receptor for TGFβ and PDGFRβ in reverse cholesterol transport and the maintenance of vascular wall integrity. Here we used a knockin mouse model to uncover a novel atheroprotective role for LRP1 in macrophages where tyrosine phosphorylation of an NPxY motif in its intracellular domain initiates a signaling cascade along an LRP1/SHC1/PI3K/AKT/PPARγ/LXR axis to regulate and integrate cellular cholesterol homeostasis through the expression of the major cholesterol exporter ABCA1 with apoptotic cell removal and inflammatory responses.
Revealing the distribution of transmembrane currents along the dendritic tree of a neuron from extracellular recordings
Authors: Cserpán Dorottya , Meszéna Domokos , Wittner Lucia , Tóth Kinga , Ulbert István , Somogyvári Zoltán , Wójcik Daniel K
Published: November 2017

Revealing the current source distribution along the neuronal membrane is a key step on the way to understanding neural computations; however, the experimental and theoretical tools to achieve sufficient spatiotemporal resolution for the estimation remain to be established. Here, we address this problem using extracellularly recorded potentials with arbitrarily distributed electrodes for a neuron of known morphology. We use simulations of models with varying complexity to validate the proposed method and to give recommendations for experimental applications. The method is applied to in vitro data from rat hippocampus.
Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo
Authors: Stadler Michael R , Haines Jenna E , Eisen Michael B
Published: November 2017

High-throughput assays of three-dimensional interactions of chromosomes have shed considerable light on the structure of animal chromatin. Despite this progress, the precise physical nature of observed structures and the forces that govern their establishment remain poorly understood. Here we present high resolution Hi-C data from early Drosophila embryos. We demonstrate that boundaries between topological domains of various sizes map to DNA elements that resemble classical insulator elements: short genomic regions sensitive to DNase digestion that are strongly bound by known insulator proteins and are frequently located between divergent promoters. Further, we show a striking correspondence between these elements and the locations of mapped polytene interband regions. We believe it is likely this relationship between insulators, topological boundaries, and polytene interbands extends across the genome, and we therefore propose a model in which decompaction of boundary-insulator-interband regions drives the organization of interphase chromosomes by creating stable physical separation between adjacent domains.
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Authors: Karch Jason , Schips Tobias G , Maliken Bryan D , Brody Matthew J , Sargent Michelle A , Kanisicak Onur , Molkentin Jeffery D
Published: November 2017

Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013). Here we show that mouse embryonic fibroblasts deficient in Bax/Bak1 are resistant to the third major form of cell death associated with autophagy through a mechanism involving lysosome permeability. Indeed, specifically targeting Bax only to the lysosome restores autophagic cell death in Bax/Bak1 null cells. Moreover, a monomeric-only mutant form of Bax is sufficient to increase lysosomal membrane permeability and restore autophagic cell death in Bax/Bak1 double-deleted mouse embryonic fibroblasts. Finally, increasing lysosomal permeability through a lysomotropic detergent in cells devoid of Bax/Bak1 restores autophagic cell death, collectively indicting that Bax/Bak integrate all major forms of cell death through direct effects on membrane permeability of multiple intracellular organelles.
Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa
Authors: Nakamura Paul A , Shimchuk Andy A , Tang Shibing , Wang Zhizhi , DeGolier Kole , Ding Sheng , Reh Thomas A
Published: November 2017

Regulation of rod gene expression has emerged as a potential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP). We previously reported on a small molecule modulator of the rod transcription factor Nr2e3, Photoregulin1 (PR1), that regulates the expression of photoreceptor-specific genes. Although PR1 slows the progression of retinal degeneration in models of RP in vitro, in vivo analyses were not possible with PR1. We now report a structurally unrelated compound, Photoregulin3 (PR3) that also inhibits rod photoreceptor gene expression, potentially though Nr2e3 modulation. To determine the effectiveness of PR3 as a potential therapy for RP, we treated RhoP23H mice with PR3 and assessed retinal structure and function. PR3-treated RhoP23H mice showed significant structural and functional photoreceptor rescue compared with vehicle-treated littermate control mice. These results provide further support that pharmacological modulation of rod gene expression provides a potential strategy for the treatment of RP.
Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
Authors: Rodriguez Camargo Diana C , Korshavn Kyle J , Jussupow Alexander , Raltchev Kolio , Goricanec David , Fleisch Markus , Sarkar Riddhiman , Xue Kai , Aichler Michaela , Mettenleiter Gabriele , Walch Axel Karl , Camilloni Carlo , Hagn Franz , Reif Bernd , Ramamoorthy Ayyalusamy
Published: November 2017

Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights into the pathology and aid in the design of compounds to potentially treat the diseases, it has not been feasible to overcome the challenges posed by the cell membrane. Here, we use NMR experimental constraints to solve the structure of a type-2 diabetes related human islet amyloid polypeptide intermediate stabilized in nanodiscs. ROSETTA and MD simulations resulted in a unique β-strand structure distinct from the conventional amyloid β-hairpin and revealed that the nucleating NFGAIL region remains flexible and accessible within this isolated intermediate, suggesting a mechanism by which membrane-associated aggregation may be propagated. The ability of nanodiscs to trap amyloid intermediates as demonstrated could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
Learning from losers
Authors: Kirkup Benjamin
Published: November 2017

Bacteria can overcome environmental challenges by killing nearby bacteria and incorporating their DNA.