bluuebunny/crossref_metadata_2025 huggingface dataset:
Contrasting reproductive strategies in a narrow latitude range: the case of D’Orbigny’s slider
Authors: Lucas Priscila Silva , Bager Alex
Published: September 2017

Reproductive traits and the level of parental investment in offspring varies between individuals and species. These are central issues in life history theory and evolutionary biology. Maternal body size plays an important role in reproduction, and we usually observe variable investment in offspring by females. Thus, optimal egg size may not be reached in some populations or species. In this study, we tested if reproductive traits differed between populations of D’Orbigny’s slider in a specific geographical area in Brazil. We evaluated the relationship between reproductive traits to maternal body size and clutch size to egg size to determine possible trade-offs across populations. At the population level, maternal body size and reproductive traits of D’Orbigny’s slider were different even in geographically nearby areas. Maternal body size had a positive effect on clutch size, but not on egg size, except in the Arroio Grande population. Nevertheless, we did not observe a negative correlation between clutch and egg size in any population. Although maternal body size had effects in the different populations explaining most of the variation of clutch size, variation in egg size may be the result of decreased survival chances in unpredictable environments and possibly morphological constraints. The trade-off between egg size and number was not observed and this could be expected if resource availability and reproductive allocation by females vary greatly among individuals.
Trade in wild anurans vectors the urodelan pathogen Batrachochytrium salamandrivorans into Europe
Authors: Nguyen Tao Thien , Nguyen Thinh Van , Ziegler Thomas , Pasmans Frank , Martel An
Published: September 2017

Pathogen pollution has caused dramatic losses of amphibian diversity on a global scale. The recently emerged chytrid fungus Batrachochytrium salamandrivorans (Bsal) has been hypothesized to have its origin in Asian urodelan populations, from which it may have been introduced to Europe through the trade in live urodelans. We here show that Bsal is present on wild small-webbed fire-bellied toads (Bombina microdeladigitora) from Vietnam and on representatives of the same species that have recently been imported in Germany. This finding suggests that the installment of measures to mitigate the Bsal threat through the amphibian trade should not be limited to urodeles, but should equally take anurans into account.
Overseas Chinese: The Early and the New, and the Difference Between Them (海外華人的過去發展與當前轉變)
Authors: Lin (林平) Ping
Published: September 2017

This special issue contains six essays discussing the lives of both early Chinese overseas migrants in the 19th century and those who have moved more recently during the past three decades. At heart is the thorny issue: what is the difference between early and new overseas Chinese? While earlier Chinese immigrants were mainly Han people from the Southeast China, who are the new Chinese immigrants and where do they come from? While early Chinese immigrants tended to be less skilled and educated, what are the socio-economic features of new Chinese immigrants? How do the early and new Chinese immigrants perceive each other if both live in the same locality? How do the people of the host countries perceive the new Chinese immigrants and the coming of Chinese investments? Each of these topics is partially addressed in this issue. More research on the rise of China and new Chinese immigrants will be the focus of future work in the field of overseas Chinese studies. (This article is in English).
Between Institutional Exclusion and Inclusion: Comparing Old and New Chinese Immigrants in South Korea (制度的排斥與包容：在韓國的舊華僑和新華僑之比較)
Authors: Lee (李承恩) Claire Seungeun
Published: September 2017

This article explores three Chinese immigrant groups in South Korea. South Korean society characterizes itself with a long-held traditional myth of being a homogenous society. Two waves of migrants from China, however, challenged this myth. The earlier wave took place in the late 19thcentury. The recent, new, wave of Chinese migration took place in the last three decades and coincidently right before and after the normalization of relations between the People’s Republic of China (prc) and South Korea in 1992. Due to the rise of China and the changing dynamics of inter-Asian migration, new migrants from theprcsince the 1990s have changed the demographic composition of foreign citizens in Korea.

These new migrants from theprcare mostly ethnic Han (prcChinese), but some are ethnic Korean (Korean Chinese) who holdprccitizenship. Most previous studies have focused on either old (earlier) Chinese immigrants or new (later) Chinese immigrants separately. This paper, in contrast, comparatively investigates these groups utilizing statistics and secondhand source data. This study contends that the mechanisms of institutional exclusion and inclusion in Korean immigration policies, put forward by the policies’ citizenship, legal and economic aspects, produce both new multiculturalism and ethnonationalism. This paper also contends that mechanisms of institutional exclusion and inclusion are a result of the interplay between citizenship and ethnicity.

本文對韓國華僑（“舊華僑”）、持中國國籍的中國大陸漢族和朝鮮族（“新華僑”）進行比較。長久以來，在韓國社會裡“單一民族”一直是一個很普遍的傳統現象。但兩波從中國到韓國的華人華僑移民潮卻反駁此現象。早期的移民潮發生在十九世紀末，在此期間移居到韓國的華人一般稱之為韓國華僑（簡稱為“韓華”）。最近這一波新移民潮則是發生在最近30多年，恰好是在發生在中華人民共和國和韓國建交的一九九二年前後。從一九九零年代開始，因中國崛起和亞洲移民的動態變化帶動的中國“新”移民到了韓國，也改變了在韓國社會裡外國剬民的國籍與種族結構。

這些來自中國的新移民大部分都是漢族（簡稱為“漢族”），有些則是朝鮮族，這兩個不同的民族都持有中華人民共和國的國籍。已經有許多研究關注移居韓國的華人，但比較不同時代移居至韓國的華人的討論卻非常少見。這個研究便以統計和二手資料為主，特別針對這些在不同時期來到韓國的華人進行比較。本論文分析了在韓國移民政策裡頭制度排斥和包容的機制，筆者分析了這些政策裡的剬民權、法律和經濟等不同層面，發現韓國的一系列移民政策造成了新的多文化主義和民族國家主義。此外，本研究也發現產生制度排斥和包容機制是剬民權和種族性之間的相互作用的結果。 (This article is in English).
Morphological characteristics and molecular data reveal two new species of Dentipellis from China
Authors: SHEN LU-LU , WANG MING
Published: September 2017

Two new species of Dentipellis are described from China based on morphological characteristics and molecular data. Dentipellis longiuscula is characterized by annual, resupinate hydnoid basidiomata with moderately long spines, rough basidiospores (5–6 × 3–3.6 µm) and absence of gloeoplerous hyphae and gloeocystidia. Dentipellis tropicalis is characterized by hydnoid basidiomata with numerous gloeocystidia presenting in hymenium, and minutely rough basidiospores (5–5.5 × 2.5–3.2 µm). Phylogenetic analysis based on the internal transcribed spacer (ITS) and nuclear large subunit ribosomal (nLSU) RNA gene regions confirmed the affinity of the new species in Dentipellis and indicated their relationships with other species in the genus.
Where are the species limits? Morphology versus genetics in Neotropical chewing lice of the genus Myrsidea (Phthiraptera: Menoponidae), with description of three new species
Authors: KOLENCIK STANISLAV , SYCHRA OLDRICH , PAPOUSEK IVO , LITERAK IVAN
Published: September 2017

Eleven species of lice of the genus Myrsidea Waterston, 1915 (Phthiraptera: Menoponidae) from passerine birds (Passeriformes: Cardinalidae, Fringillidae, Thraupidae) in the Neotropical Region are recorded and discussed. They include three new species with hosts in the family Thraupidae from Paraguay, which are described and illustrated: Myrsidea flaveolae new species ex Sicalis flaveola, Myrsidea habiae new species ex Habia rubica, and Myrsidea sayacae new species ex Thraupis sayaca. Five other previously known Myrsidea species are included with new data on intraspecific morphological variability, hosts associations and geographical distribution, as follows: Myrsidea coronatae, M. lightae, M. rufi, M. seminuda, and M. violaceae. Three further species are recorded at genus level only due to lack of adequate material. A 379 bp portion of the mitochondrial cytochrome oxidase I (COI) gene was sequenced in order to assess relative genetic divergence among Myrsidea populations. The application of intra- and interspecific sequence divergences as predictor of species boundaries in the taxonomy of this megadiverse genus is discussed.
From Synchronizing to Harmonizing: The Process of Authenticating Multiple Work Identities
Authors: Caza Brianna Barker , Moss Sherry , Vough Heather
Published: September 2017

To understand how people cultivate and sustain authenticity in multiple, often shifting, work roles, we analyze qualitative data gathered over five years from a sample of 48 plural careerists—people who choose to simultaneously hold and identify with multiple jobs. We find that people with multiple work identities struggle with being, feeling, and seeming authentic both to their contextualized work roles and to their broader work selves. Further, practices developed to cope with these struggles change over time, suggesting a two-phase emergent process of authentication in which people first synchronize their individual work role identities and then progress toward harmonizing a more general work self. This study challenges the notion that consistency is the core of authenticity, demonstrating that for people with multiple valued identities, authenticity is not about being true to one identity across time and contexts, but instead involves creating and holding cognitive and social space for several true versions of oneself that may change over time. It suggests that authentication is the emergent, socially constructed process of both determining who one is and helping others see who one is.
Unplanned 30‐Day Readmissions after Parathyroidectomy in Patients with Chronic Kidney Disease: A Nationwide Analysis
Authors: Ferrandino Rocco , Roof Scott , Ma Yue , Chan Lili , Poojary Priti , Saha Aparna , Chauhan Kinsuk , Coca Steven G. , Nadkarni Girish N. , Teng Marita S.
Published: September 2017

Objective

To examine rates of readmission after parathyroidectomy in patients with chronic kidney disease and determine primary etiologies, timing, and risk factors for these unplanned readmissions.

Study Design

Retrospective cohort study.

Setting

Nationwide Readmissions Database.

Subjects and Methods

The Nationwide Readmissions Database was queried for parathyroidectomy procedures performed in patients with chronic kidney disease between January 2013 and November 2013. Patient‐, admission‐, and hospital‐level characteristics were compared for patients with and without at least 1 unplanned 30‐day readmission. Outcomes of interest included rates, etiology, and timing of readmission. Multivariate logistic regression was used to identify predictors of 30‐day readmission.

Results

There were 2756 parathyroidectomies performed in patients with chronic kidney disease with an unplanned readmission rate of 17.2%. Hypocalcemia/hungry bone syndrome accounted for 40% of readmissions. Readmissions occurred uniformly throughout the 30 days after discharge, but readmissions for hypocalcemia/hungry bone syndrome peaked in the first 10 days and decreased over time. Weight loss/malnutrition at time of parathyroidectomy and length of stay of 5 to 6 days conferred increased risk of readmission with adjusted odds ratios (aOR) of 3.31 (95% confidence interval [CI], 1.55‐7.05; P =. 002) and 1.87 (95% CI, 1.10‐3.19; P =. 02), respectively. Relative to primary hyperparathyroidism, parathyroidectomies performed for secondary hyperparathyroidism (aOR, 2.53; 95% CI, 1.07‐5.95; P =. 03) were associated with higher risk of readmission.

Conclusion

Postparathyroidectomy readmission rates for patients with chronic kidney disease are nearly 5 times that of the general population. Careful consideration of postoperative care and electrolyte management is crucial to minimize preventable readmissions in this vulnerable population.
The Canadian Otolaryngology–Head and Neck Surgery Workforce in the Urban‐Rural Continuum: Longitudinal Data from 2002 to 2013
Authors: Crowson Matthew G. , Lin Vincent
Published: September 2017

Objectives

To evaluate the proportion of otolaryngology–head and neck surgery (OHNS) providers who are rural versus urban based from 2002 to 2013. Secondary objective was to present perspectives of rural primary care providers on unmet needs for OHNS services.

Study Design

Mixed methods database analysis and prospective survey.

Setting

National administrative database.

Subjects and Methods

The Canadian Medical Association OHNS provider Masterfile and the Statistics Canada postal code file were used to determine provincial, urban, rural, and Aboriginal group care coverage. The Society of Rural Physicians of Canada was surveyed to explore care delivery and unmet needs for OHNS and audiology. Descriptive statistics and linear regression were used to describe results.

Results

Ontario and Quebec had the largest annual OHNS physician growth (6.38 providers/year; r2 = 0.94) versus stagnant growth in the territories. The clear majority of OHNS providers are in urban centers, and rural OHNS coverage is decreasing annually (–0.33 providers/year, r2 = 0.28). There are no OHNS providers in 485 population centers where Aboriginal groups are located. A survey of 40 rural primary care providers reported that OHNS care is most commonly delivered through seasonal visits to a local facility, with otology (hearing loss, chronic ear disease) and rhinology (nonmalignant nasal or sinus conditions) as the most frequently reported unmet needs.

Conclusion

From 2002 to 2013, OHNS coverage showed a trend for urban consolidation. Most Aboriginal groups may have decreased access to care, as there are no OHNS providers in 485 population centers where reserves are located. There is an unmet need for specialized OHNS services reported by rural primary care physicians, especially otology and rhinology.
Markets, Knowledge and Human Nature: Friedrich Hayek, Karl Polanyi and Twentieth-century Debates on Modern Social Order
Authors: Innset Ola
Published: September 2017

The article reads the works of Friedrich Hayek (1899–1992) and Karl Polanyi (1886–1964) in the light of their political commitments to neoliberalism and socialism respectively. It argues that both thinkers were inspired to explain history and recent events in line with these commitments in their 1944 publications, The Road to Serfdom and The Great Transformation. Furthermore, they both developed their most significant insights by attempting to counter perceived challenges from political projects to which they were opposed. Polanyi spent much of his life trying to disprove a liberal attack on socialism as out of touch with the realities of human nature, whereas it was in debates with socialists that Hayek developed a new theory of the epistemological functioning of markets, which then became foundational for the neoliberal project. Taking into account the high-stakes politics of Vienna in the interwar years is crucial for fully understanding the social theory of these two thinkers.
Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury
Authors: Mitra Subhabrata , Bale Gemma , Highton David , Gunny Roxanna , Uria-Avellanal Cristina , Bainbridge Alan , Sokolska Magdalena , Price David , Huertas-Ceballos Angela , Kendall Giles S , Meek Judith , Tachtsidis Ilias , Robertson Nicola J
Published: September 2017

Hypoxic ischemic encephalopathy (HIE) leads to significant morbidity and mortality. Impaired autoregulation after hypoxia-ischaemia has been suggested to contribute further to injury. Thalamic lactate/N-Acetylasperate (Lac/NAA) peak area ratio of > 0.3 on proton (1H) magnetic resonance spectroscopy (MRS) is associated with poor neurodevelopment outcome following HIE. Cytochrome-c-oxidase (CCO) plays a central role in mitochondrial oxidative metabolism and ATP synthesis. Using a novel broadband NIRS system, we investigated the impact of pressure passivity of cerebral metabolism (CCO), oxygenation (haemoglobin difference (HbD)) and cerebral blood volume (total haemoglobin (HbT)) in 23 term infants following HIE during therapeutic hypothermia (HT). Sixty-minute epochs of data from each infant were studied using wavelet analysis at a mean age of 48 h. Wavelet semblance (a measure of phase difference) was calculated to compare reactivity between mean arterial blood pressure (MABP) with oxCCO, HbD and HbT. OxCCO-MABP semblance correlated with thalamic Lac/NAA ( r = 0.48, p = 0.02). OxCCO-MABP semblance also differed between groups of infants with mild to moderate and severe injury measured using brain MRI score ( p = 0.04), thalamic Lac/NAA ( p = 0.04) and neurodevelopmental outcome at one year ( p = 0.04). Pressure passive changes in cerebral metabolism were associated with injury severity indicated by thalamic Lac/NAA, MRI scores and neurodevelopmental assessment at one year of age.
Unique Interactions of Interpersonal Trauma and Positive Peer and Family Experiences on Traumatic Distress Among Pediatric Primary Care Patients
Authors: Wang Shirley B. , Herres Joanna , Diamond Guy
Published: September 2017

Individuals with histories of interpersonal trauma are at increased risk for posttraumatic stress disorder (PTSD). Risk of PTSD is particularly salient during critical periods of development, such as adolescence and emerging adulthood. However, little is known about the unique effects and interactions of protective factors and interpersonal trauma on PTSD symptoms in adolescents and young adults. The current study tested whether positive peer and family experiences decrease the associations between interpersonal trauma and PTSD symptoms and whether these associations differed by victim–perpetrator relationships. Participants included 3,618 adolescents and young adults (aged 14-24 years) who completed the Behavioral Health Screen—a web-based screening tool that assesses psychiatric symptoms and associated risk factors—during a routine visit across 10 primary care sites in Pennsylvania. In support of the stress buffering hypothesis, results revealed that positive peer and family experiences buffered the effects of interpersonal trauma by a romantic partner and an adult in the home. Future research should examine whether programs aimed at improving peer or family relationships improve outcomes for traumatized youth.
The Impact of Industrial Diversification on Employment Growth in the 50 U.S. States: 2000-2013
Authors: Pallares Francisco J. , Adkisson Richard V.
Published: September 2017

Economic developers express concern for both employment growth and employment stability. This study asks whether there is a trade-off between the quantity and reliability of jobs. Does industrial diversification, presumed to lead to more reliable jobs, have an impact (perhaps negative) on overall job growth? Using data from the 50 U.S. states from 2000 to 2013, this study explores the relationships between employment growth and industrial diversification measured in four ways. The results are mixed, suggesting that overreliance on employment in stable industries might retard employment growth but that overreliance on employment in volatile industries does not have a clear positive or negative impact on employment growth.
The Role of Mentoring in Protégés’ Subjective Well-Being
Authors: Wen Peng , Chen Cheng , Dong Longzhu , Shu Xiaobing
Published: September 2017

Although the benefits of mentoring for protégés’ career-related outcomes have been largely confirmed, little research has examined whether this benefit can extend to the protégés’ life domains outside of work. In this study, we investigate the impact of the extent of workplace mentoring support on protégés’ subjective well-being (SWB). Based on data that were collected from a two-wave survey of 253 protégés in ongoing mentoring programs in China, the results showed that the extent of the mentoring support was significantly related to the protégés’ SWB (i.e., satisfaction with life, positive affect, and negative affect) through their psychological safety. Furthermore, the perceived mentor status of protégés moderated the relationship between the extent of mentoring support and the protégés’ psychological safety, such that the relationship was stronger when the perceived mentor status was higher rather than lower. The theoretical and managerial implications of our findings are also discussed.
Aromatic polyamides and copolyamides containing fluorene group
Authors: Zhu Tengyang , Yang Xing , He Xiaoqi , Zheng Yayun , Luo Jujie
Published: September 2017

A series of new aromatic polyamides (PAs) and copolyamides (CPAs) containing fluorene group have been synthesized through polycondensation reaction. The chemical structure was confirmed by Fourier transform infrared and proton nuclear magnetic resonance (1H NMR). PAs and CPAs exhibited the higher thermal stability ( Td15 > 378°C in nitrogen), the higher glass transition temperature ( Tg > 345°C), and excellent solubility in polar solvent. Gas transport properties of the PA and CPA membranes were investigated using different single gases (hydrogen (H2), carbon dioxide (CO2), oxygen (O2), methane (CH4), and nitrogen (N2)). We discussed the effect of chemical structure and operating temperature on gas transport properties. The results show that PA-1 containing a hexafluoroisopropylidene moiety exhibited the highest gas permeability ( PH2 = 12.71 Barrer, PCO2 = 12.26 Barrer, and PO2 = 2.62 Barrer) and reasonably good selectivity ( α(H2/N2) = 27.63, α(CO2/N2) = 26.65, and α(O2/N2) = 5.70) at 25°C and 1 atm. For all the membranes, gas permeability gradually increased with the increase in operating temperature, while the selectivity gradually decreased. These gas permeation results were well correlated with fractional free volume, interchain d-spacing ( dsp), and intermolecular interaction.
Design, modeling, and analysis of wedge-based actuator with application to clutch-to-clutch shift
Authors: Liu Fengyu , Chen Li , Yao Jian , Lee Chunhao , Kao Chi-kuan , Samie Farzad , Huang Ying , Yin Chengliang
Published: September 2017

Clutch-to-clutch shift technology is a key enabler for fast and smooth gear shift process for multi gear transmissions. However, conventional hydraulic actuation systems for clutches have drawbacks of low efficiency, oil leakage and inadequate robustness. Electromechanical devices offer potential alternative actuators. In this paper, a novel motor driven wedge-based clutch actuator, featuring self-reinforcement, is proposed. The design concept and physical structure are thoroughly described. Dynamic models for the actuation system and vehicle powertrain are validated by experiments. Upshift and downshift processes at different engine throttle openings, clutch clearances and friction coefficients are discussed. The results show that, the self-reinforcement ratio is tested as 9.6; at the same time, the shift quality is comparable to that of the conventional hydraulic actuated clutch in automatic transmissions in terms of the shift duration (about 1 s) and vehicle jerk (<10 m/s3). Taking advantage of fast response of the actuation DC motor, the wedge-based actuator is robust dealing with uncertain clutch clearance and friction coefficient. Therefore, the wedge-based clutch actuator has potential to provide acceptable performance for clutch-to-clutch shift.
Relationship of Preservice Music Teachers’ Primary Instrument Background and Teaching Effectiveness in Brass and Woodwind Techniques Classes
Authors: Powell Sean R. , Weaver Molly A. , Henson Robin K.
Published: September 2017

The purpose of this study was to examine the relationship between preservice music teachers’ primary instrument background and their teaching effectiveness in brass and woodwind techniques classes. Study participants ( N = 135) were preservice music teachers enrolled in secondary instrument techniques courses (brass and woodwinds) from fall 2011 through spring 2015 in three universities. Participants taught a 10-minute video recorded lesson to a beginning-level university student on a brass or woodwind instrument at the end of the semester. All videos were subsequently assessed by two researchers using a researcher-designed rubric. The results of analyses of variance showed that brass-teaching scores tended to be higher than woodwind-teaching scores for all groups. Brass players taught brass more effectively than woodwind players, and woodwind players taught woodwinds better than brass players. Brass and woodwind players scored higher than percussionists, vocalists, pianists, and string players in both brass and woodwind teaching. Implications for music teacher education are discussed.
A Case Report of Steroid Responsive Nivolumab-Induced Encephalitis
Authors: Richard Kaja , Weslow Jacqueline , Porcella Stephanie L. , Nanjappa Sowmya
Published: September 2017

Nivolumab (Opdivo) approval for the treatment of non-small cell lung cancer (NSCLC) prompts recognition of its future use in various cancers. Although rare, occurring in 1% to 3% of treated cases, nivolumab along with other immune checkpoint inhibitors are associated with immune-related encephalitis. With its prospective use, nivolumab-induced encephalitis illustrates the necessity of early recognition and successful management to decrease morbidity and mortality. We describe a treated case of nivolumab-induced encephalitis. A 74-year-old male with a history of stage 4 squamous NSCLC presenting with insidious altered mental status following his first dose of nivolumab. After an extensive workup that proved negative, the patient received intravenous steroids with gradual improvement of mental status. Patient subsequently returned to baseline and was discharged with oral steroid taper. Nivolumab-induced encephalitis is a diagnosis of exclusion with nonspecific signs and symptoms. Immediate recognition of patients prescribed nivolumab chemotherapy could potentially prevent fatal complications of neurotoxicity.
Cardiac Potassium Channels: Physiological Insights for Targeted Therapy
Authors: Jeevaratnam Kamalan , Chadda Karan R. , Huang Christopher L.-H. , Camm A. John
Published: September 2017

The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that minimizes potential cardiac and extracardiac toxicity. Of these, K+ channels contribute numerous and diverse currents with specific actions on different phases in the time course of AP repolarization. These features and their site-specific distribution make particular K+ channel types attractive therapeutic targets for the development of pharmacological agents attempting antiarrhythmic therapy in conditions such as atrial fibrillation. However, progress in the development of such temporally and spatially selective antiarrhythmic drugs against particular ion channels has been relatively limited, particularly in view of our incomplete understanding of the complex physiological roles and interactions of the various ionic currents. This review summarizes the physiological properties of the main cardiac potassium channels and the way in which they modulate cardiac electrical activity and then critiques a number of available potential antiarrhythmic drugs directed at them.
Viral Causes of Lymphoma: The History of Epstein-Barr Virus and Human T-Lymphotropic Virus 1
Authors: Esau Daniel
Published: September 2017

In 1964, Epstein, Barr, and Achong published a report outlining their discovery of viral particles in lymphoblasts isolated from a patient with Burkitt lymphoma. The Epstein-Barr virus (EBV) was the first human cancer virus to be described, and its discovery paved the way for further investigations into the oncogenic potential of viruses. In the decades following the discovery of EBV, multinational research efforts led to the discovery of further viral causes of various human cancers. Lymphomas are perhaps the cancer type that is most closely associated with oncogenic viruses: infection with EBV, human T-lymphotropic virus 1 (HTLV-1), human immunodeficiency virus (HIV), Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, and hepatitis C virus have all been associated with lymphomagenesis. Lymphomas have also played an important role in the history of oncoviruses, as both the first human oncovirus (EBV) and the first human retrovirus (HTLV-1) were discovered through isolates taken from patients with unique lymphoma syndromes. The history of the discovery of these 2 key oncoviruses is presented here, and their impact on further medical research, using the specific example of HIV research, is briefly discussed.
Frontline Therapy for Classical Hodgkin Lymphoma by Stage and Prognostic Factors
Authors: Allen Pamela B , Gordon Leo I
Published: September 2017

Hodgkin lymphoma is a highly curable malignancy in early and advanced stages. Most patients are diagnosed in their teens or twenties and are expected to live decades beyond their treatment. Therefore, the toxicity of treatment must be balanced with the goal of cure. Thus, treatment has been refined through prognostic models and positron emission tomography-computed tomography (PET-CT)-directed therapy. Stratification by prognostic models defines groups of patients with favorable characteristics who may be treated with less intensive therapy upfront, including fewer cycles of chemotherapy, lower doses of radiation, or omission of radiation altogether. Alternatively, high-risk patients may be assigned to a more aggressive initial approach. The modern use of interim PET-CT allows further tailoring of treatment by response.
Grief as an extended emotion
Authors: Brinkmann Svend , Kofod Ester Holte
Published: September 2017

In recent years, human scientists have generalized the so-called hypothesis of the extended mind to human emotional life. The extended mind hypothesis states that objects within the environment function as a part of the mind and are centrally involved in cognition. Some emotion researchers have argued along these lines that there are bodily extended emotions, and (more controversially) environmentally extended emotions. In this article, we will first briefly introduce the idea of the extended mind and extended emotions before applying it to the emotion of grief specifically. We explain by introducing the notion of a cultural affective niche within which grief is scaffolded and enacted. An affective niche couples the person and the environment and enables the realization of affective states.
Development and evaluation of diversity-oriented competence training for the treatment of depressive disorders
Authors: Sempértegui Gabriela A. , Knipscheer Jeroen W. , Bekker Marrie H. J.
Published: September 2017

Studies in Europe indicate that some ethnic minorities have higher rates of mental disorders and less favorable treatment outcomes than their counterparts from majority groups. To date, efforts regarding training to reduce disparities have mainly focused on ethnocultural competences of therapists, with less attention paid to other aspects of diversity, such as sex/gender and socioeconomic status. In this study, we aim to determine the effectiveness of a population-specific, diversity-oriented competence training designed to increase therapists’ competencies to integrate aspects of diversity features in clinical assessment, diagnosis, and treatment of depressive disorders in Turkish- and Moroccan-Dutch patients. A group of 40 therapists were location-based assigned to either training or a control condition (no training). Self-reported diversity competence, a knowledge test, and therapists’ satisfaction with training were used to monitor the training and to measure competence levels at baseline, post-training, and three-month follow-up. Attitude-awareness and knowledge components of the self-reported diversity competence and test-measured knowledge increased in the training condition. Most gains remained stable at follow-up except test-measured knowledge after controlling for percentage of ethnic minority patients in caseload. There were no changes regarding therapists’ self-reported skills. Therapists expressed medium–high satisfaction with the training, acknowledging the relevance of diversity competence for their daily practice. Future training must ensure better adjustment to therapists’ pre-existing knowledge and be followed by long-term efforts to maintain competence levels and enhance competence transfer within teams.
Renal Tumor Invasion Depth and Diameter are the Two Most Accurate Anatomical Features Regarding the Choice of Radical Versus Partial Nephrectomy
Authors: Tornberg S. V. , Kilpeläinen T. P. , Järvinen P. , Visapää H. , Järvinen R. , Taari K. , Nisén H.
Published: September 2017

Background and Aims:

To evaluate simple tumor characteristics (renal tumor diameter and parenchymal invasion depth) compared with more complex classifications, that is, Renal Tumor Invasion Index (RTII) and Preoperative Aspects and Dimensions Used for an Anatomical classification, in predicting the type of nephrectomy (radical vs partial) performed.

Material and Methods:

A total of 915 patients who had undergone either partial nephrectomy ( n = 388, 42%) or radical nephrectomy ( n = 527, 58%) were identified from the Helsinki University Hospital kidney tumor database between 1 January 2006 and 31 December 2014. Tumor maximum diameter and depth of invasion into the parenchyma were estimated from computed tomography or magnetic resonance imaging images and compared with Preoperative Aspects and Dimensions Used for an Anatomical and Renal Tumor Invasion Index. Logistic regression and receiver operating curves were used to compare the parameters at predicting the type of nephrectomy.

Results and conclusion:

All the anatomical variables of receiver operating curve/area under the curve analyses were significant predictors for the type of nephrectomy. Parenchymal invasion (area under the curve 0.91; 95% confidence interval, 0.89–0.93), RTII (area under the curve 0.91; 95% confidence interval, 0.89–0.93), and diameter (area under the curve 0.91; 95% confidence interval, 0.89–0.93) performed significantly better than Preoperative Aspects and Dimensions Used for an Anatomical classification (area under the curve 0.88; 95% confidence interval, 0.85–0.89). In multivariable analysis, invasion depth was the best predictor of nephrectomy type (percentage correct, 85.6%). Addition of one anatomic parameter into the model of non-anatomical cofactors improved the accuracy of the model significantly, but the addition of more parameters did not. Parenchymal invasion depth and tumor diameter are the most accurate anatomical features for predicting the nephrectomy type. All potential anatomical classification systems should be tested against these two simple characteristics.
The Medicine Tree: Unsettling palaeoecological perceptions of past environments and human activity
Authors: Richer Suzi , Gearey Benjamin
Published: September 2017

In this paper, we consider palaeoecological approaches to past landscapes and reflect upon how these are relevant to archaeological themes concerning concepts of environmental change and the role of past and present human communities in these processes. In particular, we highlight the importance of local context in the perception and understanding of landscape. Utilising a case study from Nepal, we look to ‘unsettle’ a conventional palaeoecological interpretation of a pollen record, originally constructed on western ecological principles, and instead draw on an interpretative perspective rooted in local Buddhist ecological knowledge, or a ‘folk taxonomy’, known as ‘The Medicine Tree’. We discuss how the interpretations of patterns and processes of vegetation change from a pollen record are not necessarily absolute. In particular, we outline how the palaeoecological frame of enquiry and reference is rooted in an essentially Eurocentric, Western scientific paradigm, which, in turn, shapes how we perceive and conceive of past landscapes and the role of ‘anthropogenic impact’ on vegetation. The aim of this is not to suggest that scientific approaches to the ‘reconstruction’ of past landscapes are necessarily invalid, but to illustrate how ‘empirical’ scientific methods and interpretations in archaeological science are contingent upon specific social and cultural frames of reference. We discuss the broader relevance of this, such as how we interpret past human activity and perception of landscape change, the ways in which we might look to mobilise research in the context of contemporary problems, issues concerning ‘degraded landscapes’ and how we incorporate local and archaeological perspectives with palaeoecology within an interconnected and iterative process.
The need for statistical contributions to bioinformatics at scale, with illustration to mass spectrometry
Authors: Dowsey Andrew W
Published: September 2017

In their article, Morris and Baladandayuthapani clearly evidence the influence of statisticians in recent methodological advances throughout the bioinformatics pipeline and advocate for the expansion of this role. The latest acquisition platforms, such as next generation sequencing (genomics/transcriptomics) and hyphenated mass spectrometry (proteomics/metabolomics), output raw datasets in the order of gigabytes; it is not unusual to acquire a terabyte or more of data per study. The increasing computational burden this brings is a further impediment against the use of statistically rigorous methodology in the pre-processing stages of the bioinformatics pipeline. In this discussion I describe the mass spectrometry pipeline and use it as an example to show that beneath this challenge lies a two-fold opportunity: (a) Biological complexity and dynamic range is still well beyond what is captured by current processing methodology; hence, potential biomarkers and mechanistic insights are consistently missed; (b) Statistical science could play a larger role in optimizing the acquisition process itself. Data rates will continue to increase as routine clinical omics analysis moves to large-scale facilities with systematic, standardized protocols. Key inferential gains will be achieved by borrowing strength across the sum total of all analyzed studies, a task best underpinned by appropriate statistical modelling.
Boundaries and Boundary Objects: An Evaluation Framework for Mixed Methods Research
Authors: Wenger-Trayner Beverly , Wenger-Trayner Etienne , Cameron Josh , Eryigit-Madzwamuse Suna , Hart Angie
Published: September 2017

While mixed methods research is increasingly established as a methodological approach, researchers still struggle with boundaries arising from commitments to different methods and paradigms, and from attention to social justice. Combining two lines of work—social learning theory and the Imagine Program at the University of Brighton—we present an evaluation framework that was used to integrate the perspectives of multiple stakeholders in the program’s social interventions. We explore how this “value-creation framework” acts as a boundary object across “boundaries of practice,” specifically across quantitative and qualitative methods, philosophical paradigms, and participant perspectives. We argue that the framework’s focus on cycles of value creation provided the Imagine Program with a shared language for negotiating interpretation and action across those boundaries.
‘We pretty much just watched it all back to back!’
Authors: Frolova Ksenia
Published: September 2017

This article offers an empirical account of audience’s experience of television viewing and television flow, with a specific focus on parents as the audience group. It approaches the study of the medium from the standpoint of researching television as a lived experience, offering an insight into how television viewing practices and the experience of television flow are influenced by the complex experiences of parenting. In particular, this article addresses questions such as how audience’s specific experiences and circumstances, such as parenting, influence the ways in which television content is accessed and viewed; what is parents’ experience of flow when it comes to television viewing; and whether broadcast flow of television is becoming a contested and insecure concept in its own right, with audiences making a distinction between ‘broadcast television in the background’ and ‘watching television’.
The Financial Impact of Inaccurate Blood Glucose Monitoring Systems
Authors: Fortwaengler Kurt , Campos-Náñez Enrique , Parkin Christopher G. , Breton Marc D.
Published: September 2017

Objective:

An in silico study of type 1 diabetes (T1DM) patients utilized the UVA-PADOVA Type 1 Diabetes Simulator to assess the effect of patient blood glucose monitoring (BGM) system accuracy on clinical outcomes. We applied these findings to assess the financial impact of BGM system inaccuracy.

Methods:

The study included 43 BGM systems previously assessed for accuracy according to ISO 15197:2003 and ISO 15197:2013 criteria. Glycemic responses for the 100 in silico adult T1DM subjects were generated, using each meter. Changes in estimated HbA1c, severe hypoglycemic events, and health care resource utilization were computed for each simulation. The HbA1c Translator modeling approach was used to calculate the financial impact of these changes.

Results:

The average cost of inaccuracy associated with the entire group of BGM systems was £155 per patient year (PPY). The average additional cost of BGM systems not meeting the ISO 15197:2003 standard was an estimated £178 PPY more than an average system that fulfills the standard and an estimated £235 PPY more than an average system that appears to meet the ISO 15197:2013 standard.

Conclusion:

There is a clear relationship between BGM system accuracy and cost, with the highest costs being associated with BGM systems not meeting the ISO 15197:2003 standard. Lower costs are associated with systems meeting the ISO 15197:2013 system accuracy criteria. Using BGM systems that meet the system accuracy criteria of the ISO 15197:2013 standard can help reduce the clinical and financial consequences associated with inaccuracy of BGM devices.
A prospective, observational, longitudinal cohort study of sedation practices in SGH intensive care units
Authors: Lee Yi Lin , Ganesh Kalyanasundaram , Ti Lian Kah , Ng Shin Yi
Published: September 2017

Background:

Critically ill patients require sedation for patient comfort and ventilator synchrony. Despite the extensive use of sedation, to date there is no consensus on the best sedation practices. We attempt to investigate our local sedation practices.

Method:

This was a single-centre prospective, observation cohort study in medical and surgical intensive care unit (ICU) patients who were ventilated and sedated for more than 24 hours. Baseline demographics were obtained and patients followed-up for 28 days or to ICU discharge. Details on sedatives, ventilation duration, vasopressors and renal replacement therapy use, hospital/ICU length of stay, mortality, delirium, and sedation depth were collected and analysed.

Results:

From March to July 2012, 58 patients were recruited with a mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score of 20.2 ±8.5. Hospital mortality rates were 32.8%. Patients were followed-up for 387 ICU patient-days. In the early period (first 48 h), the most popular sedative used was propofol (74.1%), followed by morphine (29.3%). In the subsequent period (>48 h), most patients were not sedated (47.6%); morphine became the most popular sedation drug (32.5%) followed by propofol (31%). Ketamine, haloperidol and diazepam were not given. In total, 1994 Richmond Agitation and Sedation Score (RASS) assessments were performed over 387 ICU patient-days; 11.1% of RASS assessments were prescribed a sedation target, and 86% of them met the prescribed targets. Delirium was observed in 22.4% of patients. Compared with medical patients, surgical patients were more likely to be prescribed a sedation target (14.2% vs. 7.4%, p<0.01), require lower doses of sedation, have a RASS score of between −2 to 1 (84.8% vs. 72.3%, p<0.01) and have fewer incidences of delirium (4.1% vs. 12.1%, p=0.01).

Conclusion:

Propofol and morphine were the most commonly prescribed sedatives. Different sedation practices between units may contribute to a reduction in delirium incidence.
Biomechanical evaluation of native acromioclavicular joint ligaments and two reconstruction techniques in the presence of the sternoclavicular joint: A cadaver study
Authors: Masionis Povilas , Šatkauskas Igoris , Mikelevičius Vytautas , Ryliškis Sigitas , Bučinskas Vytautas , Griškevičius Julius , Martin Oliva Xavier , Monzó Planella Mariano , Porvaneckas Narūnas , Uvarovas Valentinas
Published: September 2017

Background:

Where is over 100 reconstruction techniques described for acromioclavicular (AC) joint reconstruction. Although, it is not clear whether the presence of the sternoclavicular (SC) joint influences the biomechanical properties of native AC ligaments and reconstruction techniques. The purpose of the present study was to investigate the biomechanical properties of native AC joint ligaments and two reconstruction techniques in cadavers with the SC joint still present.

Materials and Methods:

We tested eight fresh-frozen cadaver hemithoraces for superior translation (70 N load) and translation increment after 1000 cycles (loading from 20 to 70 N) in a controlled laboratory study. There were three testing groups created: native ligaments, the single coracoclavicular loop (SCL) technique, and the two coracoclavicular loops (TCL) technique. Superior translation was measured after static loading. Translation increment was calculated as the difference between superior translation after cyclic and static loading.

Results:

Native AC ligaments showed significantly lower translation than the SCL ( p = 0.023) and TCL ( p = 0.046) groups. The SCL had a significantly lower translation increment than native AC ligaments ( p = 0.028). There was no significant difference between reconstruction techniques in terms of translation ( p = 0.865) and translation increment ( p = 0.113).

Conclusions:

Native AC joint ligaments had better static properties than both reconstruction techniques and worse dynamic biomechanical properties than the SCL technique. The SCL technique appeared to be more secure than the TCL technique. The presence of the SC joint did not have an observable influence on test results.
Safety of Intravitreal Injection Guide
Authors: Watanabe Kei , Masafumi Uematsu , Mohamed Yasser H. , Watanabe Takehito , Doi Yusuke , Azusa Fujikawa , Kitaoka Takashi
Published: September 2017

Purpose:

To evaluate the safety of our developed intravitreal injection guide.

Methods:

Retrospective review of all case notes for consecutive patients treated with intravitreal anti-vascular endothelial growth factor (VEGF) injections at the Department of Ophthalmology, Nagasaki University Hospital in Japan between January 2013 and December 2014. We included all patients who had at least 1 intravitreal anti-VEGF injection done within the study period. Data collected included demographics, indications of intravitreal anti-VEGF injections, type of injected drug, usage of intravitreal guide, experience of physicians, and any complication that occurred during or after the procedure.

Results:

The study included 256 patients (154 males and 102 females) who underwent 992 intravitreal anti-VEGF injections from January 2013 until December 2014. The mean age of the patients was 70.8 ± 11.3 years. Of total injections, 907 (91.44%) were done using the intravitreal guide, 60 (6.04%) were done without using the guide, and only 25 (2.52%) injections were not determined. Local complications include 1 (0.1%) case uveitis, 1 (0.1%) case retinal tear, and 1 (0.1%) case amaurosis fugax. There were no major complications as cataract, retinal detachment, and endophthamitis. No systemic complication was encountered. All complications occurred in the guide group without statistically significant difference in comparison to without guide group ( P = 1.0). All complications were related to experienced group without significant difference in comparison to limited experienced group ( P = .28).

Conclusion:

We conclude that the process of intravitreal injection with our developed intravitreal injection guide is safe and easy even for limited experienced physicians.