bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathway to Decarbonization Through Industrial Energy Efficiency: Micro and Macro Perspectives from Compressed Air Usage
Authors: McNelly Megan , Choi Jun-Ki
Published: June 2024

Energy audits directly provided the industrial sector with reduced energy costs and avoided emissions. Still, they also lead to far-reaching indirect and induced local, regional, and national benefits. This paper aims to present the techno-economic-environmental analysis to achieve decarbonization through implementing industrial energy efficiency at micro and macro levels. An integrated techno-economic-environmental methodology is developed. Case studies of micro-level carbon reduction efforts through industrial energy efficiency technologies are presented. The broader macroeconomic and environmental effects of technology on society are analyzed using data from 206 energy audits of industrial compressed air systems conducted over 13 years. The impacts show that energy-efficient improvements lead to direct cost savings for manufacturers, boost economic activity across sectors, and affect carbon dioxide emissions both short-term and long-term in the region. Given their extensive benefits, energy audits significantly influence policymaking. We devised a methodology to link micro-level energy audit data with macroeconomic and environmental analyses to quantify these cascading benefits. The economic scenario analysis shows that $228 M has been saved from direct industrial energy savings from implementing all compressed air recommendations in the studied periods and the region. In addition, the investment made through manufacturers would create 2,025 jobs and $383 M annually, cascading regional economic impacts. The environmental analysis shows that the regional manufacturers have directly avoided about 2.8 M metric tons of carbon dioxide emissions.
Hybrid structure of maximal ideals in near rings
Authors: Jebapresitha B.
Published: June 2024

A hybrid structure is an arrangement that makes use of many hierarchical reporting structures and is applied to algebraic structures such as groups and rings. In the discipline of abstract algebra, an ideal of a near-ring is a unique subset of its elements in ring theory. Ideals generalize specific subsets of integers, such as even numbers or multiples of three. Researchers have been using mathematical theories of fuzzy sets in ring theory to explain the uncertainties that emerge in various domains such as art and science, engineering, medical science, and in environment. By fusing soft sets and fuzzy sets, a new mathematical tool that has significant advantages in dealing with uncertain information is provided. Consequently, there is always some discrepancy between reality's haziness and its mathematical model's precision. Hence ring theory has been widely used in many researches but there is some uncertainty in converting the fuzzy sets to a hybrid structure of any algebraic structure. Many approaches were done in groups. Therefore, the Hybrid structure of fuzzy sets in near rings is introduced, in which the fuzzy ideals are converted to hybrid ideals and fuzzy maximal ideals are converted to hybrid maximal ideals. For hybridization, firstly the hybrid structure is established and then sub-near rings and near rings are also determined. Then the hybrid structure of sub-near rings and ideals is introduced. This converts the fuzzy ideals and fuzzy maximal ideals to hybrid ideals and hybrid maximal ideals. The result obtained by the proposed model efficiently solved the uncertainty problems and the effectiveness of the proposed approach shows the best class, mean, worst class, and time complexity.
Influence of reconstruction uncertainty in fiber orientation distribution on the effective elastic constants of composites reinforced with discontinuous fibers: a Monte Carlo simulation study
Authors: Ogierman Witold
Published: June 2024

The orientation distribution of fibers in discontinuous fiber composite materials is influenced by various factors associated with the manufacturing process. Predicting fiber orientation distribution can be achieved through software simulation of the process or experimental methods, such as X-ray computed tomography. As uncertainties related to the reconstruction of fiber orientation distribution may be unavoidable in practical cases, this paper investigates the impact of some of these uncertainties on the effective elastic constants of composites through Monte Carlo simulations. The primary objective of this study is to address how the ratio of fiber detection and the measurement error of individual fiber orientation influence the orientation tensors and effective elastic constants. To predict the elastic properties of composites under various scenarios of fiber orientation distributions, a micromechanical model incorporating an orientation averaging procedure has been used. Three cases of different fiber orientation distributions have been analyzed. The conducted Monte Carlo simulations enabled the presentation of a quantitative description of the uncertainty associated with the reconstruction of the orientation distribution of fibers, including the effective elastic constants. The resulting distributions of orientation tensors and elastic constants have been analyzed and discussed.
The Multidimensional Prognostic Index predicts incident delirium among hospitalized older patients with COVID-19: a multicenter prospective European study
Authors: Morganti Wanda , Custodero Carlo , Veronese Nicola , Topinkova Eva , Michalkova Helena , Polidori M. Cristina , Cruz‐Jentoft Alfonso J. , von Arnim Christine A. F. , Azzini Margherita , Gruner Heidi , Castagna Alberto , Cenderello Giovanni , Custureri Romina , Seminerio Emanuele , Zieschang Tania , Padovani Alessandro , Sanchez‐Garcia Elisabet , Pilotto Alberto ,   the MPI-COVID-19 Study Group Investigators, Barbagallo Mario , Barbagelata Marina , Dini Simone , Diesner Naima Madlen , Fernandes Marilia , Gandolfo Federica , Garaboldi Sara , Musacchio Clarissa , Pilotto Andrea , Pickert Lena , Podestà Silvia , Ruotolo Giovanni , Sciolè Katiuscia , Schlotmann Julia
Published: June 2024

Purpose

Incident delirium is a frequent complication among hospitalized older people with COVID-19, associated with increased length of hospital stay, higher morbidity and mortality rates. Although delirium is preventable with early detection, systematic assessment methods and predictive models are not universally defined, thus delirium is often underrated. In this study, we tested the role of the Multidimensional Prognostic Index (MPI), a prognostic tool based on Comprehensive Geriatric Assessment, to predict the risk of incident delirium.

Methods

Hospitalized older patients (≥ 65 years) with COVID-19 infection were enrolled (n = 502) from ten centers across Europe. At hospital admission, the MPI was administered to all the patients and two already validated delirium prediction models were computed (AWOL delirium risk-stratification score and Martinez model). Delirium occurrence during hospitalization was ascertained using the 4A’s Test (4AT). Accuracy of the MPI and the other delirium predictive models was assessed through logistic regression models and the area under the curve (AUC).

Results

We analyzed 293 patients without delirium at hospital admission. Of them 33 (11.3%) developed delirium during hospitalization. Higher MPI score at admission (higher multidimensional frailty) was associated with higher risk of incident delirium also adjusting for the other delirium predictive models and COVID-19 severity (OR = 12.72, 95% CI = 2.11–76.86 for MPI-2 vs MPI-1, and OR = 33.44, 95% CI = 4.55–146.61 for MPI-3 vs MPI-1). The MPI showed good accuracy in predicting incident delirium (AUC = 0.71) also superior to AWOL tool, (AUC = 0.63) and Martinez model (AUC = 0.61) (p < 0.0001 for both comparisons).

Conclusions

The MPI is a sensitive tool for early identification of older patients with incident delirium.
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver
Authors: Danek Przemysław J. , Daniel Władysława A.
Published: June 2024

Background

Our recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome P450 (CYP), as demonstrated in vitro on human hepatocytes and in vivo on the rat liver. The aim of the present work was to study the effect of repeated treatment with asenapine, iloperidone, and lurasidone on the expression of transcription factors regulating CYP drug-metabolizing enzymes in rat liver.

Methods

The hepatic mRNA (qRT-PCR) and protein levels (Western blotting) of aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor (PPARγ) were measured in male Wistar rats after 2 week-treatment with asenapine, iloperidone or lurasidone.

Results

The 2-week treatment with asenapine significantly diminished the AhR and PXR expression (mRNA, protein level), and CAR mRNA level in rat liver. Iloperidone lowered the AhR and CAR expression and PXR protein level. Lurasidone did not affect the expression of AhR and CAR, but increased PXR expression. The antipsychotics did not affect PPARγ.

Conclusions

Prolonged treatment with asenapine, iloperidone, or lurasidone affects the expression of transcription factors regulating the CYP drug-metabolizing enzymes. The changes in the expression of AhR, CAR, and PXR mostly correlate with alterations in the expression and activity of respective CYP enzymes found in our previous studies. Since these transcription factors are also engaged in the expression of phase II drug metabolism and drug transporters, changes in their expression may affect the metabolism of endogenous substrates and pharmacokinetics of concomitantly used drugs.
Assessing factors influencing greywater characteristics around the world: a qualitative and quantitative approach with a short-review on greywater treatment technologies
Authors: Mohan S. , Manthapuri Vineeth , Chitthaluri Santhoshi
Published: June 2024

The obsolete efficiencies in conventional centralized wastewater treatment systems call for implementation of source separation and treatment of wastewater. Approximately 60–75% of domestic wastewater is attributed to greywater, which could be reused to combat freshwater crisis. The present study investigates qualitative and quantitative attributes of greywater from different sources in High-Income Countries (HICs) and Low-Income Countries (LICs). The quantity of greywater generation is positively correlated with country’s per capita income, but feebly negatively correlated with temperature. Kitchen source is the highest contributor of total suspended solids (134–1300 mg/l), whereas in case of turbidity, laundry is the major contributor (39–444 NTU). Also, kitchen greywater is characterized by comparatively high biochemical oxygen demand (BOD) of 100–1850 mg/l, low pH of 5.6–8, and elevated total nitrogen (TN) of about 1.5–48 mg/l. The high pH (7.3–10) and chemical oxygen demand (COD) levels (58–2497 mg/l) in laundry greywater are due to usage of sodium hydroxide-based soaps, while usage of wash detergents containing phosphates like sodium tripolyphosphate contribute to high total phosphorus (TP) (0.062–57 mg/l). The qualitative characteristics of greywater in HICs are perceived to be superior compared to LICs. Furthermore, the most widely used physicochemical, biological, and advanced oxidation treatment technologies for greywater are outlined briefly. It can be observed that economical treatment systems like phytoremediation or biological technologies combined with sand filtration systems can be implemented to treat greywater with high organic content in LICs, whereas in HICs where greywater is generated in large quantities, electro-coagulation combined with advanced oxidation technologies can be used to treat its higher COD levels.

Graphical Abstract
Unlocking environmental solutions: a review of cyclodextrins in pollutant removal
Authors: Urooj Tuba , Mishra Monika , Pandey Shivam
Published: June 2024

Cyclodextrins are cyclic oligosaccharides characterized by a hydrophobic interior and a hydrophilic outside linked by α-1,4 glycosidic bonds. Cyclodextrins are biodegradable and generally considered environmentally friendly. These are utilized in diverse applications, encompassing environmental cleanup which is enhanced through the processes of cross-linking or surface modification. These molecules have a unique structure that enables them to form inclusion complexes with various guest molecules, including organic pollutants, pesticides, dyes, pharmaceuticals, and hydrocarbons. When used in water treatment, cyclodextrins can act as molecular sponges, trapping pollutants within their cavities through non-covalent interactions such as hydrogen bonding, van der Waals forces, and hydrophobic interactions. When cyclodextrins are introduced into water containing pollutants, the pollutants can enter the cavities of cyclodextrin molecules, forming inclusion complexes. This process effectively sequesters the pollutants from the surrounding water, reducing their concentration. It can often be regenerated and reused multiple times, making them cost-effective for water treatment applications. This review presents the primary applications of cyclodextrins for the adsorption of contaminants from various pollutants from diverse sources, based on recent publications.
Complex Multi‐Fault Dynamics in Sikkim Himalaya: New Insights From Local Earthquake Analysis
Authors: Uthaman Mita , Singh Chandrani , Singh Arun , Hetényi György , Dutta Abhisek , Kumar Gaurav , Dubey Arun Kumar
Published: June 2024

Anomalously overturned thrust faults, lineaments and segmentation causing cross‐cutting basement structures characterize the tectonic setting of Sikkim Himalaya. However, its seismotectonics is poorly constrained along with the speculated northward extension of the Dhubri‐Chungthang Fault Zone (DCFZ) causing segmentation. Here, we utilize the precise location of newly acquired local earthquake data and fault plane solutions using full‐waveform moment tensor inversion to better constrain seismically active zones. Transtensional shearing along the Main Himalayan Thrust in central Sikkim is possibly incited by fluid‐rich upper‐crust. Cessation of the mapped 20 km wide mid‐crustal seismogenic zone of DCFZ at Chungthang and its northward discontinuation into the Higher Himalayas is confirmed by the striking variation in focal mechanisms. Earthquakes along imbricated segments in the lower‐crust originate possibly in response to crustal shortening. Extensional shearing along the Moho triggers seismicity to the northwest of Sikkim. Such complex tectonic dynamics instigating persistent seismicity indicates high potential for future great earthquakes in Sikkim Himalaya.
Biological Production of Distinct Carbon Pools Drives Particle Export Efficiency in the Southern Ocean
Authors: Huang Yibin , Fassbender Andrea J.
Published: June 2024

We use observations from the Southern Ocean (SO) biogeochemical profiling float array to quantify the meridional pattern of particle export efficiency (PEeff) during the austral productive season. Float estimates reveal a pronounced latitudinal gradient of PEeff, which is quantitatively supported by a compilation of existing ship‐based measurements. Relying on complementary float‐based estimates of distinct carbon pools produced through biological activity, we find that PEeff peaks near the region of maximum particulate inorganic carbon sinking flux in the polar antarctic zone, where net primary production (NPP) is the lowest. Regions characterized by intermediate NPP and low PEeff, primarily in the subtropical and seasonal ice zones, are generally associated with a higher fraction of dissolved organic carbon production. Our study reveals the critical role of distinct biogenic carbon pool production in driving the latitudinal pattern of PEeff in the SO.
Presence of Frozen Fringe Impacts Soft‐Bedded Slip Relationship
Authors: Hansen D. D. , Warburton K. L. P. , Zoet L. K. , Meyer C. R. , Rempel A. W. , Stubblefield A. G.
Published: June 2024

Glaciers and ice streams flowing over sediment beds commonly have a layer of ice‐rich debris adhered to their base, known as a “frozen fringe,” but its impact on basal friction is unknown. We simulated basal slip over granular beds with a cryogenic ring shear device while ice infiltrated the bed to grow a fringe, and measured the frictional response under different effective stresses and slip speeds. Frictional resistance increased with increasing slip speed until it plateaued at the frictional strength of the till, closely resembling the regularized Coulomb slip law associated with clean ice over deformable beds. We hypothesize that this arises from deformation in a previously unidentified zone of weakly frozen sediments at the fringe's base, which is highly sensitive to temperature and stress gradients. We show how a rheologic model for ice‐rich debris coupled with the thermomechanics of fringe growth can account for the regularized Coulomb behavior.
Rapid Primary Sulfate Aerosol Generation Observed With OP‐FTIR in the Eruptive Plume of the Fagradalsfjall Basaltic Eruption, Iceland, 2021
Authors: Smekens Jean‐François , Mather Tamsin A. , Burton Mike R. , Varnam Matthew , Pfeffer Melissa A.
Published: June 2024

Open‐Path Fourier‐Transform Infrared (OP‐FTIR) absorption spectroscopy is a powerful method for remote characterization of volcanic plume composition from safe distances. Many studies have used it to examine the composition of volcanic gas emitted at the surface, which is influenced by initial volatile contents and magma ascent/storage processes, and help to reveal the dynamics controlling surface activity. However, to evaluate the health hazard threats associated with volcanic emissions and their potential impact on wider atmospheric conditions, near‐source particle measurements are also key. Here we present a forward model and fitting algorithm which allows quantification of particle size and abundance. This was successfully applied to radiometrically uncalibrated OP‐FTIR spectra collected with a highly dynamic radiation source during the Fagradalsfjall eruption, Iceland, on 11 August 2021. Quantification of plume temperatures ranging from 350 to 650 K was essential to characterize the emission‐absorption behavior of SO2, enabling retrievals of particulate matter in the thermal infrared spectral window (750–1250 cm−1) in each spectrum. For the first time, we observe the rapid formation of primary aerosols in young plumes (only a few seconds old) with OP‐FTIR. Temperature‐dependent SO2/SO42− molar ratios range from 100 to 250, consistent with a primary formation mechanism controlled by cooling and entrainment of atmospheric gases. This novel aerosol spectrum retrieval opens new frontiers in field‐based measurements of sulfur partitioning and volcanic plume evolution, with the potential to improve volcano monitoring and quantification of air quality hazard assessments.
Responses of Marginal and Intrinsic Water‐Use Efficiency to Changing Aridity Using FLUXNET Observations
Authors: Yi Koong , Novick Kimberly A. , Zhang Quan , Wang Lixin , Hwang Taehee , Yang Xi , Mallick Kanishka , Béland Martin , Senay Gabriel B. , Baldocchi Dennis D.
Published: June 2024

According to classic stomatal optimization theory, plant stomata are regulated to maximize carbon assimilation for a given water loss. A key component of stomatal optimization models is marginal water‐use efficiency (mWUE), the ratio of the change of transpiration to the change in carbon assimilation. Although the mWUE is often assumed to be constant, variability of mWUE under changing hydrologic conditions has been reported. However, there has yet to be a consensus on the patterns of mWUE variabilities and their relations with atmospheric aridity. We investigate the dynamics of mWUE in response to vapor pressure deficit (VPD) and aridity index using carbon and water fluxes from 115 eddy covariance towers available from the global database FLUXNET. We demonstrate a non‐linear mWUE‐VPD relationship at a sub‐daily scale in general; mWUE varies substantially at both low and high VPD levels. However, mWUE remains relatively constant within the mid‐range of VPD. Despite the highly non‐linear relationship between mWUE and VPD, the relationship can be informed by the strong linear relationship between ecosystem‐level inherent water‐use efficiency (IWUE) and mWUE using the slope, m*. We further identify site‐specific m* and its variability with changing site‐level aridity across six vegetation types. We suggest accurately representing the relationship between IWUE and VPD using Michaelis–Menten or quadratic functions to ensure precise estimation of mWUE variability for individual sites.
Inversion of Sea Surface Currents From Satellite‐Derived SST‐SSH Synergies With 4DVarNets
Authors: Fablet R. , Chapron B. , Le Sommer J. , Sévellec F.
Published: June 2024

Satellite altimetry offers a unique approach for direct sea surface current observation, but it is limited to measuring the surface‐constrained geostrophic component. Ageostrophic dynamics, prevalent at horizontal scales below 100 km and time scales below 10 days, are often underestimated by ocean reanalyzes employing data assimilation schemes. To address this limitation, we introduce a novel deep learning scheme, rooted in a variational data assimilation formulation with trainable observations and a priori terms, that harnesses the synergies between satellite‐derived sea surface observations, namely sea surface height (SSH) and sea surface temperature (SST), to enhance sea surface current reconstruction. Numerical experiments, conducted using realistic simulations, in a case study area of the Gulf Stream, demonstrate the potential of the proposed scheme to capture ageostrophic dynamics at time scales of 2.5–3.0 days and horizontal scales of 0.5°–0.7°. The analysis of diverse observation configurations, encompassing nadir along‐track altimetry, wide‐swath SWOT (Surface Water and Ocean Topography) altimetry, and SST data, highlights the pivotal role of SST features in retrieving a significant portion of the ageostrophic dynamics (approximately 47%). These findings underscore the potential of deep learning and 4DVarNet schemes in improving ocean reanalyzes and enhancing our understanding of ocean dynamics.
Zeitlin Truncation of a Shallow Water Quasi‐Geostrophic Model for Planetary Flow
Authors: Franken A. D. , Caliaro M. , Cifani P. , Geurts B. J.
Published: June 2024

In this work, we consider a Shallow‐Water Quasi Geostrophic equation on the sphere, as a model for global large‐scale atmospheric dynamics. This equation, previously studied by Verkley (2009, https://doi.org/10.1175/2008jas2837.1) and Schubert et al. (2009, https://doi.org/10.3894/james.2009.1.2), possesses a rich geometric structure, called Lie‐Poisson, and admits an infinite number of conserved quantities, called Casimirs. In this paper, we develop a Casimir preserving numerical method for long‐time simulations of this equation. The method develops in two steps: first, we construct an N‐dimensional Lie‐Poisson system that converges to the continuous one in the limit N → ∞; second, we integrate in time the finite‐dimensional system using an isospectral time integrator, developed by Modin and Viviani (2020, https://doi.org/10.1017/jfm.2019.944). We demonstrate the efficacy of this computational method by simulating a flow on the entire sphere for different values of the Lamb parameter. We particularly focus on rotation‐induced effects, such as the formation of jets. In agreement with shallow water models of the atmosphere, we observe the formation of robust latitudinal jets and a decrease in the zonal wind amplitude with latitude. Furthermore, spectra of the kinetic energy are computed as a point of reference for future studies.
Reduced‐Order Probabilistic Emulation of Physics‐Based Ring Current Models: Application to RAM‐SCB Particle Flux
Authors: Cruz Alfredo A. , Siddalingappa Rashmi , Mehta Piyush M. , Morley Steven K. , Godinez Humberto C. , Jordanova Vania K.
Published: June 2024

In this work, we address the computational challenge of large‐scale physics‐based simulation models for the ring current. Reduced computational cost allows for significantly faster than real‐time forecasting, enhancing our ability to predict and respond to dynamic changes in the ring current, valuable for space weather monitoring and mitigation efforts. Additionally, it can also be used for a comprehensive investigation of the system. Thus, we aim to create an emulator for the Ring current‐Atmosphere interactions Model with Self‐Consistent magnetic field (RAM‐SCB) particle flux that not only improves efficiency but also facilitates forecasting with reliable estimates of prediction uncertainties. The probabilistic emulator is built upon the methodology developed by Licata and Mehta (2023), https://doi.org/10.1029/2022sw003345. A novel discrete sampling is used to identify 30 simulation periods over 20 years of solar and geomagnetic activity. Focusing on a subset of particle flux, we use Principal Component Analysis for dimensionality reduction and Long Short‐Term Memory (LSTM) neural networks to perform dynamic modeling. Hyperparameter space was explored extensively resulting in about 5% median symmetric accuracy across all data sets for one‐step dynamic prediction. Using a hierarchical ensemble of LSTMs, we have developed a reduced‐order probabilistic emulator (ROPE) tailored for time‐series forecasting of particle flux in the ring current. This ROPE offers accurate predictions of omnidirectional flux at a single energy with no pitch angle information, providing robust predictions on the test set with an error score below 11% and calibration scores under 8% with bias under 2% providing a significant speed up as compared to the full RAM‐SCB run.
Evidence for an Imbricated Lower Crust and Its Role in Accommodating Crustal Shortening in Sikkim Himalaya
Authors: Singh Arun , Kumar Gaurav , Singh Chandrani , Kumar M. Ravi , Uthaman Mita , Vadlamani Ravikant , Dutta Abhisek , Saikia Dipankar , Dubey Arun Kumar
Published: June 2024

Geometrical heterogeneity of the subducting Indian continental crust along the Himalaya‐Tibet collision zone remains enigmatic. Mass budget estimates describing shortening across the orogen are partly derived from observations made from seismic imaging of the deep earth. Here, using data from 38 broadband seismic stations covering Sikkim Himalaya, we produce high resolution seismic images in order to fill crucial gaps in our understanding of the evolution of Himalayan collision zone. We used 12,288 high quality receiver functions computed using waveforms of earthquakes having magnitude >5.5 in the distance range of 30°–100°. Our results reveal a highly imbricated and heterogeneous crust beneath Sikkim Himalaya. The Main Himalayan Thrust (MHT) responsible for large scale earthquakes in the Himalayan collision zone is not so distinct in the migrated images, but intermittent. A dominant cluster of earthquakes at shallower depths is associated with the MHT, marked by negative amplitude arrivals. The Moho is found to be gently dipping, reaching depths of ∼60 km beneath the Higher Himalaya compared to ∼40 km in the Himalayan foredeep. Interestingly, the Moho in this part of Himalaya has offsets and overlapping segments, indicating crustal imbrication in response to active shortening. Clusters of lower crustal earthquakes coincide with the junction of offsets in the Moho.
Importance of Variable Turbine Efficiency in Run‐Of‐River Hydropower Design Under Deep Uncertainty
Authors: Yildiz Veysel , Brown Solomon , Rougé Charles
Published: June 2024

When less water is available, hydropower turbines are less efficient, or have to stop altogether. This reality is often neglected in recent work on the planning and operations of hydropower systems, despite widespread expected increases in drought intensity, frequency and duration. This paper is the first to integrate variable‐efficiency turbines into a hydropower plant design framework that accounts for design optimization as well as deep uncertainty in climatic and socio‐economic variables. Specifically, this framework focuses on leveraging multi‐objective robust decision making for the financially robust design of run‐of‐river hydropower plants, whose output is highly sensitive to flow variability. Application to five plants in Türkiye challenges two key design assumptions, use of net present value as a design objective and use of identical turbines. Instead, maximizing the benefit‐cost ratio yields plants with better financial viability over a range of plausible futures. They tend to have smaller capacity, and feature a small turbine that is well‐adapted to low‐flow periods. Another key insight is that socio‐economic uncertainties have as much or even more impact on robustness than climate conditions. In fact, these uncertainties have the potential to make many small hydropower projects too risky to build. Our findings are of considerable practical relevance at a time where 140 GW of unexploited small hydropower potential could help power the energy transition. They also highlight the need for similar research in reservoir‐based plants, considering over 3,000 such plants planned or in construction worldwide.
Interactions of Logjams, Channel Dynamics, and Geomorphic Heterogeneity Within a River Corridor
Authors: Marshall Anna , Wohl Ellen , Iskin Emily , Zeller Lucas
Published: June 2024

Natural rivers are inherently dynamic. Spatial and temporal variations in water, sediment, and wood fluxes both cause and respond to an increase in geomorphic heterogeneity within the river corridor. We analyze 16 two‐km river corridor segments of the Swan River in Montana, USA to examine relationships between logjams (distribution density, count, and persistence), channel dynamism (total sinuosity and average channel migration), and geomorphic heterogeneity (patch density) in the river corridor. We hypothesize that (a) more dynamic river segments correlate with a greater presence, persistence, and distribution of logjams; (b) higher annual peak discharges correspond with greater channel dynamism and logjam presence and distribution; and (c) greater logjam distribution densities and channel dynamism are predictive of more spatially heterogeneous sections of the river corridor. Our results suggest that, first, decadal‐scale channel dynamism, as reflected in total sinuosity, corresponds to greater numbers of logjams and greater persistence of logjams through time. Second, higher peak discharges correspond to greater presence and distribution of logjams, but not to greater channel dynamism. Third, greater geomorphic heterogeneity in the river corridor, as reflected in the spatial distribution of landscape patch density, is explained by greater logjam distribution density, total sinuosity, and proportions of beaver meadows. Our results reflect the complex interactions of water, sediment, and wood in river corridors; the difficulties of interpreting causal relationships among these variables through time; and the importance of spatial and temporal analyses of past and present river processes to understand future river conditions.
MAGPRIME: An Open‐Source Library for Benchmarking and Developing Interference Removal Algorithms for Spaceborne Magnetometers
Authors: Hoffmann Alex Paul , Moldwin Mark B. , Imajo Shun , Finley Matthew G. , Sheinker Arie
Published: June 2024

Magnetometers are essential instruments in space physics, but their measurements are often contaminated by various external interference sources. In this work, we present a comprehensive review of existing magnetometer interference removal methods and introduce MAGPRIME (MAGnetic signal PRocessing, Interference Mitigation, and Enhancement), an open‐source Python library featuring a collection of state‐of‐the‐art interference removal algorithms. MAGPRIME streamlines the process of interference removal in magnetic field data by providing researchers with an integrated, easy‐to‐use platform. We detail the design, structure, and functionality of the library, as well as its potential to facilitate future research by enabling rapid testing and customization of interference removal methods. Using the MAGPRIME Library, we present two Monte Carlo benchmark results to compare the efficacy of interference removal algorithms in different magnetometer configurations. In Benchmark A, the Underdetermined Blind Source Separation (UBSS) and traditional gradiometry algorithms surpass the uncleaned boom‐mounted magnetometers, achieving improved correlation and reducing median error in each simulation. Benchmark B tests the efficacy of the suite of MAGPRIME algorithms in a boomless magnetometer configuration. In this configuration, the UBSS algorithm proves to significantly reduce median error, along with improvements in median correlation and signal to noise ratio. This study highlights MAGPRIME's potential in enhancing magnetic field measurement accuracy in various spacecraft designs, from traditional gradiometry setups to compact, cost‐effective alternatives like bus‐mounted CubeSat magnetometers, thus establishing it as a valuable tool for researchers and engineers in space exploration and magnetism studies.
Radioactive Sediments May Have Built Earth’s Cratons
Authors: Barbuzano Javier
Published: June 2024

Weathering of the earliest continents could have set in motion the formation of cratons, the immutable roots of continents.
Magmatic Storage and Volatile Fluxes of the 2021 La Palma Eruption
Authors: Dayton K. , Gazel E. , Wieser P. E. , Troll V. R. , Carracedo J. C. , Aulinas M. , Perez‐Torrado F. J.
Published: June 2024

The 2021 La Palma eruption (Tajogaite) was unprecedented in magnitude, duration, and degree of monitoring compared to historical volcanism on La Palma. Here, we provide data on melt inclusions in samples from the beginning and end of the eruption to compare the utility of both melt and fluid inclusions as recorders of magma storage. We also investigated compositional heterogeneities within the magmatic plumbing system. We found two populations of olivine crystals: a low Mg# (78–82) population present at the beginning and end of eruption, recording the maximum volatile contents (2.5 wt % H2O, 1,800 ppm F, 700 ppm Cl, 3,800 ppm S) and a higher Mg# (83–86) population sampled toward the end of the eruption, with lower volatile contents. Despite their host composition, melt inclusions share the same maximum range of CO2 concentrations (1.2–1.4 wt %), indicating olivine growth and inclusion capture at similar depths. Overall, both melt and fluid inclusions record similar pressures (450–850 MPa, ∼15–30 km), and when hosted in the same olivine crystal pressures are indistinguishable within error. At these mantle pressures, CO2 is expected to be an exsolved phase explaining the similar range of CO2 between the two samples, but other volatile species (F, Cl, S) behave incompatibly, and thus, the increase between the two olivine populations can be explained by fractional crystallization prior to eruption. Finally, based on our new data, we provide estimates on the total volatile emission of the eruption.
A Synoptic View of Mantle Plume Shapes Enabled by Virtual Reality
Authors: Lu Qianyi , Rudolph Maxwell L.
Published: June 2024

The shapes of mantle plumes are sensitive to mantle viscosity, density structure, and flow patterns. Increasingly, global tomographic models reveal broad plume conduits in the lower mantle and highly tilting conduits in the mid and upper mantle. Previous studies mostly relied on 2D slices to analyze plume shapes, but fully investigating the complexity of 3D plume structures requires more effective visualization methods. Here, we use immersive headset‐based virtual reality (VR) to visualize the full‐waveform global tomographic models SEMUCB‐WM1 and GLAD‐M25. We develop criteria for the identification of plume conduits based on the relationship between the plume excess temperature and the VS anomaly (δVS). We trace 20 major plume conduits, measure the offsets of the conduits in azimuth and distance with respect to the hotspots, calculate the tilt angle, and evaluate the δVS along all traced conduits. We compare our traced conduits with the conduits predicted by global mantle convection models and vertical conduits. The wavespeed variations along conduits traced from each tomographic model are slower than modeled or vertical conduits, regardless of which tomographic model they are evaluated in. The shapes of traced conduits tend to differ greatly from modeled conduits. Plume ponding and the emergence of secondary plumes, which could result from a combination of compositional variations, phase transitions, small‐scale convection, and variations in viscosity, can contribute to the complex observed plume shapes. The variation of δVS along the traced conduits and complex plume shapes suggest a thermochemical origin of many plumes.
Microbial Autotrophy Recorded by Carbonate Dual Clumped Isotope Disequilibrium
Authors: Ingalls Miquela , Leapaldt Hanna C. , Lloyd Max K.
Published: June 2024

The proliferation of microbial carbon fixation is a key control on the evolution of the biosphere and global carbon cycle. Most records of these metabolisms in ancient rocks come from organic matter or fossils, which are not always preserved. Here, we present a potential proxy for microbial carbon fixation (autotrophy) based on the isotopic composition of carbonate minerals. Autotrophs influence carbonate chemistry in the cellular microenvironment by decreasing CO2 concentration and increasing the carbonate saturation state. This can induce rapid precipitation of carbonate minerals that are out of isotopic equilibrium with their environment. Recent work has identified disequilibrated dual clumped isotope compositions (∆47 and ∆48) in the skeletal fossils of marine calcifying organisms. Here we test whether the same is true of non‐skeletal carbonate fabrics associated with microbial autotrophs in modern and Eocene lakes. We found that microbial carbonate formed via autotrophic metabolism recorded lower ∆47 and higher ∆48 values (−∆47/+∆48) than predicted for thermodynamic equilibrium mineral formation. Our findings are supported by models of dual clumped isotope kinetics in the DIC system, and disequilibrium in the oxygen isotope system. We hypothesize that the inverse trajectory away from the equilibrium line (+∆47/−∆48) should be recorded by carbonates formed in association with alkalinizing heterotrophs, such as sulfate reducers. If so, carbonate dual clumped isotopes could be a powerful tool to identify the proliferation and rate of heterotrophic and autotrophic metabolisms in the carbonate rock record on Earth and (perhaps) other planets.
Guidelines for Managing Radon Hazards in Tourist Volcanic Caves in Spain
Authors: Hernández‐Gutiérrez Luis E. , Calderón‐Guerrero Carlos , Martín‐Rosales Wenceslao , Rodríguez‐Martín Jesica , Cruz‐Pérez Noelia , Hernández‐Martín Helena , García‐Gil Alejandro , Santamarta Juan C.
Published: June 2024

Tourist volcanic caves are in high demand for ecotourism and geotourism lovers, as well as by sun and beach tourists as a complementary activity during their holidays. There are six tourist volcanic caves in the Canary Islands, all of them managed by the local administration of the island. The managers of these caves must ensure the safety of visitors and workers, who are exposed to natural hazards, such as radon, inherent to the environment in which the activity takes place. The methodology for analyzing natural radon radiation is based on the latest studies published by experts in this field and on previous experiences in tourist caves. This article proposes a protocol for the correct management of radon in tourist caves in the Canary Islands, adapted to current regulations, to mitigate effects on the health of visitors and workers.
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer
Authors: Saatci Ozge , Alam Rashedul , Huynh-Dam Kim-Tuyen , Isik Aynur , Uner Meral , Belder Nevin , Ersan Pelin Gulizar , Tokat Unal Metin , Ulukan Burge , Cetin Metin , Calisir Kubra , Gedik Mustafa Emre , Bal Hilal , Sener Sahin Ozlem , Riazalhosseini Yasser , Thieffry Denis , Gautheret Daniel , Ogretmen Besim , Aksoy Sercan , Uner Aysegul , Akyol Aytekin , Sahin Ozgur
Published: June 2024

Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER + ) breast cancer, constituting around 75% of all cases. However, the emergence of resistance is common, necessitating the identification of novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen resistance by blocking tamoxifen-induced ferroptosis, an iron-mediated cell death. Mechanistically, inhibiting LINC00152 reduces the mRNA stability of phosphodiesterase 4D (PDE4D), leading to activation of the cAMP/PKA/CREB axis and increased expression of the TRPC1 Ca2+ channel. This causes cytosolic Ca2+ overload and generation of reactive oxygen species (ROS) that is, on the one hand, accompanied by downregulation of FTH1, a member of the iron sequestration unit, thus increasing intracellular Fe2+ levels; and on the other hand, inhibition of the peroxidase activity upon reduced GPX4 and xCT levels, in part by cAMP/CREB. These ultimately restore tamoxifen-dependent lipid peroxidation and ferroptotic cell death which are reversed upon chelating Ca2+ or overexpressing GPX4 or xCT. Overexpressing PDE4D reverses LINC00152 inhibition-mediated tamoxifen sensitization by de-activating the cAMP/Ca2+/ferroptosis axis. Importantly, high LINC00152 expression is significantly correlated with high PDE4D/low ferroptosis and worse survival in multiple cohorts of tamoxifen- or tamoxifen-containing endocrine therapy-treated ER+ breast cancer patients. Overall, we identified LINC00152 inhibition as a novel mechanism of tamoxifen sensitization via restoring tamoxifen-dependent ferroptosis upon destabilizing PDE4D, increasing cAMP and Ca2+ levels, thus leading to ROS generation and lipid peroxidation. Our findings reveal LINC00152 and its effectors as actionable therapeutic targets to improve clinical outcome in refractory ER+ breast cancer.
Golgi dispersal in cancer stem cells promotes chemoresistance of colorectal cancer via the Golgi stress response
Authors: Li Yangkun , Mu Lei , Li Yanqi , Mi Yulong , Hu Yibing , Li Xiaolan , Tao Deding , Qin Jichao
Published: June 2024

Chemotherapy is a crucial treatment for colorectal tumors. However, its efficacy is restricted by chemoresistance. Recently, Golgi dispersal has been suggested to be a potential response to chemotherapy, particularly to drugs that induce DNA damage. However, the underlying mechanisms by which Golgi dispersal enhances the capacity to resist DNA-damaging agents remain unclear. Here, we demonstrated that DNA-damaging agents triggered Golgi dispersal in colorectal cancer (CRC), and cancer stem cells (CSCs) possessed a greater degree of Golgi dispersal compared with differentiated cancer cells (non-CSCs). We further revealed that Golgi dispersal conferred resistance against the lethal effects of DNA-damaging agents. Momentously, Golgi dispersal activated the Golgi stress response via the PKCα/GSK3α/TFE3 axis, resulting in enhanced protein and vesicle trafficking, which facilitated drug efflux through ABCG2. Identification of Golgi dispersal indicated an unexpected pathway regulating chemoresistance in CRC.
Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α
Authors: Peng Yu , Qian Hui , Xu Wen-Ping , Xiao Meng-Chao , Ding Chen-Hong , Liu Fang , Hong Huan-Yu , Liu Shu-Qing , Zhang Xin , Xie Wei-Fen
Published: June 2024

Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in hepatocellular carcinoma (HCC) remain unknown. Hepatocyte nuclear factor 1α (HNF1α) is a key transcriptional factor that plays a significant role in regulating hepatocyte differentiation and liver function. The reduced expression of HNF1α is a critical event in the development of HCC, but the underlying mechanism for its degradation remains elusive. In this study, we discovered that the expression of TRIM8 was upregulated in HCC tissues, and was positively correlated with aggressive tumor behavior of HCC and shorter survival of HCC patients. Overexpression of TRIM8 promoted the proliferation, colony formation, invasion, and migration of HCC cells, while TRIM8 knockdown or knockout exerted the opposite effects. RNA sequencing revealed that TRIM8 knockout suppresses several cancer-related pathways, including Wnt/β-catenin and TGF-β signaling in HepG2 cells. TRIM8 directly interacts with HNF1α, promoting its degradation by catalyzing polyubiquitination on lysine 197 in HCC cells. Moreover, the cancer-promoting effects of TRIM8 in HCC were abolished by the HNF1α-K197R mutant in vitro and in vivo. These data demonstrated that TRIM8 plays an oncogenic role in HCC progression through mediating the ubiquitination of HNF1α and promoting its protein degradation, and suggests targeting TRIM8-HNF1α may provide a promising therapeutic strategy of HCC.
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease
Authors: Kan Shuyan , Hou Qing , Shi Jinsong , Zhang Mingchao , Xu Feng , Liu Zhihong , Jiang Song
Published: June 2024

Peroxisomal l-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between EHHADH expression and diabetic kidney disease has not been well understood. Here, we found that endogenous EHHADH levels were strongly correlated with the progression and severity of diabetic nephropathy in T2D patients. EHHADH knockout mice exhibited worsened renal tubular injury in diabetic mice. Furthermore, EHHADH is a modulator of pexophagy. In renal tubular epithelial cells (RTECs) in vitro, the knockdown of EHHADH induced a dramatic loss of peroxisomes. The loss of peroxisomes in EHHADH-deficient RTECs was restored by either an autophagic inhibitor 3-methyladenine or bafilomycin A1 both in vitro and in vivo. NBR1 was required for pexophagy in EHHADH-knockdown cells, where the level of reactive oxygen species (ROS) was increased, while inhibition of ROS blocked pexophagy. In summary, our findings revealed EHHADH deficiency accelerated renal injury in DKD as a modulator of pexophagy.
Microbiota succession influences nematode physiology in a beetle microcosm ecosystem
Authors: Lo Wen-Sui , Sommer Ralf J. , Han Ziduan
Published: June 2024

Unravelling the multifaceted and bidirectional interactions between microbiota and host physiology represents a major scientific challenge. Here, we utilise the nematode model, Pristionchus pacificus, coupled to a laboratory-simulated decay process of its insect host, to mimic natural microbiota succession and investigate associated tripartite interactions. Metagenomics reveal that during initial decay stages, the population of vitamin B-producing bacteria diminishes, potentially due to a preferential selection by nematodes. As decay progresses to nutrient-depleted stages, bacteria with smaller genomes producing less nutrients become more prevalent. Lipid utilisation and dauer formation, representing key nematode survival strategies, are influenced by microbiota changes. Additionally, horizontally acquired cellulases extend the nematodes’ reproductive phase due to more efficient foraging. Lastly, the expressions of Pristionchus species-specific genes are more responsive to natural microbiota compared to conserved genes, suggesting their importance in the organisms’ adaptation to its ecological niche. In summary, we show the importance of microbial successions and their reciprocal interaction with nematodes for insect decay in semi-artificial ecosystems.