bluuebunny/crossref_metadata_2025 huggingface dataset:
Depressive Symptoms and Achievement Goals: Parental Rejection as a Moderator
Authors: Măirean Cornelia , Diaconu-Gherasim Loredana R.
Published: June 2019

This present study investigated the longitudinal relations between depressive symptoms and achievement goals and whether maternal and paternal rejection moderated these relations. A sample of 436 early adolescents ([Formula: see text]age = 13.19, 58.33% girls) filled in scales measuring the depressive symptoms (Time 1), parental rejection (Time 2; 1 year later), and achievement goals (Time 2). Early adolescents’ depressive symptoms were positively related to performance-avoidance goals and negatively related to mastery and performance-approach goals. Furthermore, the father’s rejection was positively related to the adolescents’ performance-avoidance and negatively related to mastery goals, whereas maternal rejection was not related to achievement goals. Finally, maternal rejection moderated the association between depressive symptoms and performance-avoidance goals 1 year later. The implications of these results for future studies and educational practices are discussed.
LncRNA PAPAS may promote triple-negative breast cancer by downregulating miR-34a
Authors: Kong Yan , Geng Cuizhi , Dong Qian
Published: June 2019

Objective

To investigate the role of promoter and pre-rRNA antisense (PAPAS) long noncoding (Lnc) RNA in cancer biology.

Methods

Tumour and tumour-adjacent healthy tissue biopsies from patients with triple-negative breast cancer (TNBC), and plasma samples from these patients plus healthy controls, were assessed for PAPAS and microRNA (miR)-34a. Effects of PAPAS and miR-34a overexpression were also investigated in vitro.

Results

PAPAS was upregulated in tumour tissues of patients with TNBC versus tumour-adjacent healthy tissues. Plasma PAPAS levels were also upregulated in patients with TNBC versus healthy controls. Levels of PAPAS in tumour tissue was significantly positively correlated with PAPAS levels in plasma from patients with TNBC. MiR-34a was downregulated in tumour tissues versus adjacent healthy tissues, and was significantly correlated with PAPAS in tumour tissues. PAPAS overexpression in vitro was associated with miR-34a inhibition, while miR-34a failed to significantly affect PAPAS levels. PAPAS overexpression promoted in vitro migration and invasion of TNBC cells, while miR-34a overexpression was inhibitory. MiR-34a overexpression decreased the enhanced cell migration and invasion associated with PAPAS overexpression. PAPAS overexpression showed no significant effects on cancer-cell proliferation.

Conclusion

LncRNA PAPAS may promote TNBC by downregulating miR-34a.
Severe polymorphic erythema due to interferon α-2b during treatment of hairy cell leukemia
Authors: Li Chen , Geng Hui , Ji Linhua , Jiang Yan , Ma Xiaojing , Yin Qichao , Xiong Hua
Published: June 2019

A 54-year-old woman with hairy cell leukemia developed severe polymorphic erythema and blisters on the trunk and limbs after injection of interferon (IFN) α-2b. Skin biopsy revealed lymphocytic exocytosis and perivascular lymphocytic infiltrate in the dermis, and the lesions improved after methylprednisolone pulse therapy. Although injection-site reactions have been observed after injection of IFNα-2b, this is the first report of a widespread cutaneous reaction to IFNα-2b.
Dynamical delimitation of the Central American Dry Corridor (CADC) using drought indices and aridity values
Authors: Quesada-Hernández Luis Eduardo , Calvo-Solano Oscar David , Hidalgo Hugo G , Pérez-Briceño Paula M , Alfaro Eric J
Published: June 2019

The Central American Dry Corridor (CADC) is a sub-region in the isthmus that is relatively drier than the rest of the territory. Traditional delineations of the CADC’s boundaries start at the Pacific coast of southern Mexico, stretching south through Central America’s Pacific coast down to northwestern Costa Rica (Guanacaste province). Using drought indices (Standardized Precipitation Index, Modified Rainfall Anomaly Index, Palmer Drought Severity Index, Palmer Hydrological Drought Index, Palmer Drought Z-Index and the Reconnaissance Drought Index) along with a definition of aridity as the ratio of potential evapotranspiration (representing demand of water from the atmosphere) over precipitation (representing the supply of water), we proposed a CADC delineation that changes for normal, dry and wet years. The identification of areas that change their classification during extremely dry conditions is important because these areas may indicate the location of future expansion of aridity associated with climate change. In the same way, the delineation of the CADC during wet extremes allows the identification of locations that remain part of the CADC even during the wettest years and that may require special attention from the authorities.
Total Recycled Asphalt Mixes: Characteristics and Field Performance
Authors: Safi Fazal R. , Al-Qadi Imad L. , Hossain Kamal , Ozer Hasan
Published: June 2019

The use of recycled materials in asphalt concrete (AC) pavement has increased significantly because of their economic and environmental benefits. The use of recycled materials can pose risks to the performance of asphalt pavements, however. The Illinois Department of Transportation developed five total recycled asphalt (TRA) mixes in the pursuit of environmentally sustainable pavements. These mixes contain up to 60% asphalt binder replacement (ABR) obtained from reclaimed asphalt pavement (RAP) and recycled asphalt shingles. Virgin aggregates were replaced by 100% recycled aggregates including RAP, steel slag, and recycled concrete aggregate (RCA). Based on laboratory testing, all the mixes offered excellent rutting resistance because of their high ABR content. The TRA mixes were relatively less compliant and not very sensitive to field aging, whereas indirect tensile strength tests showed indistinguishable results. All mixes had comparable complex modulus |E*| and phase angle ([Formula: see text]) values at low temperatures. Laboratory-compacted specimens had relatively low flexibility index (FI) compared with field cores taken after construction. The FI values of the field cores decreased with aging, higher recycled materials content, or both. An exponential increase in transverse cracking was observed in the field cores because of their relatively high ABR, RCA/steel slag content, or both. The progression of field transverse cracking over time and FI values are well correlated. A three-dimensionally balanced mix design was introduced and used successfully to distinguish between AC mixes; it is proposed as a tool for better control mix designs and optimum field performance.
Bicyclist Crash Comparison of Mixing Zone and Fully Split Phase Signal Treatments at Intersections with Protected Bicycle Lanes in New York City
Authors: Sundstrom Carl A. , Quinn Sean M. , Weld Roger
Published: June 2019

This study builds on the success of New York City’s protected bicycle lanes (PBLs) through improving the understanding and impacts of different intersection designs. Specifically, to understand better the safety of the two primary intersection design treatments for single direction PBLs, the mixing zone and fully split phase signal, several different data sources are used in a before–after and cross-sectional analysis including; 184 intersections, nearly 17 years of reported bicycle injury crashes at intersections, and historic bicycle volume and turning movement counts. It was found that, following the installation of PBLs, the rate of crashes per bicyclist decreased by an average of 30%. The study also identified similar benefits between mixing zones and fully split phases at intersections with lower turn volumes while at higher turn volume locations the shorter mixing zones have the lowest crash rates. For wider cross-streets, the crash risk for bicycle riders increased regardless of the treatment, however fully split phase intersections perform better at wider crossings overall. Based on these results, it is recommended that the fully split phase treatment should be typically prioritized where the safety need is greatest, such as at wider intersections and two-way cross-streets. In addition, these findings reinforce the need to reduce turn speeds and cyclist exposure at multilane crossings.
Severe Bone Marrow Edema Among Patients Who Underwent Prior Marrow Stimulation Technique Is a Significant Predictor of Graft Failure After Autologous Chondrocyte Implantation
Authors: Merkely Gergo , Ogura Takahiro , Bryant Tim , Minas Tom
Published: June 2019

Background:

Autologous chondrocyte implantation (ACI) is a well-established cartilage repair procedure; however, numerous studies have shown higher ACI graft failure rates after prior marrow stimulation techniques (MSTs).

Purpose:

To identify which factors may predict decreased graft survival after ACI among patients who underwent a prior MST. A secondary aim was to investigate the specificity of these predictors.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

In this review of prospectively collected data, the authors analyzed 38 patients who had failed prior MST surgery and subsequently underwent collagen-covered ACI (case group). The case group was divided into graft failure ACI (n = 8, 21%) and successful ACI (n = 30, 79%). Fourteen clinical variables were categorized and analyzed to determine predictors for failure of the ACI graft: age, body mass index, sex, defect characteristics (number, size, location, etiology, type), presence of kissing lesion, intraoperative presence of intralesional osteophyte, time between an MST and ACI, previous surgery, duration of the symptoms, and concomitant surgical procedure. Preoperative magnetic resonance imaging (MRI) was used to evaluate the severity of subchondral bone marrow edema (BME), graded I (absent) to IV (severe), and the presence of subchondral cyst, hypertrophic sclerosis, and intralesional osteophyte. The effects of these MRI findings on the graft survivor were also investigated. Concurrently, a control group without a prior MST was matched to investigate the specificity of the previously determined predictors. These patients were matched individually according to age, sex, body mass index, and outcome of the procedure (failure [n = 8] or successful [n = 30] per the case group).

Results:

In the case group, the presence of preoperative severe BME was significantly higher among patients with failed ACI as compared with patients with successful ACI ( P < .001). In the control group, the presence of severe BME was not significantly different between the failure and successful groups ( P = .747). The ACI graft failure rate among patients with a prior MST and preoperative grade IV BME was 83.7% at 5 years postoperatively, resulting in a significantly lower survival rate as compared with patients with a prior MST and without severe BME (5-year graft failure rate, 6.5%; P < .001). All the other parameters did not differ significantly.

Conclusion:

After a prior MST, the presence of grade IV BME by MRI was a predictive factor for graft failure among patients who then underwent second-generation ACI.
Estimating the value of implementing reimbursement decisions: What can payers and manufacturers learn from economics?
Authors: Dixon Simon
Published: June 2019

Implementation of reimbursement decisions is important to payers and manufacturers, however, evidence shows that it is highly variable. An economic framework is available to assess its value that has been successfully applied and which has developed over time to produce a more realistic representation of the real world. The framework incorporates the value of information, technology diffusion, and the interaction between the two, to generate a value of implementation. While potentially complex to apply, simple analyses are possible and qualitative lessons identified from its associated literature. Six lessons are identified which highlight the importance of considering pricing, population size, technology diffusion, evidence generation, and cost-effectiveness. Consideration of these issues would help payers and manufacturers to work together in a combined effort to increase the implementation of new technologies and generate greater value to society.
Borrelia lusitaniae Infection Mimicking Headache, Neurologic Deficits, and Cerebrospinal Fluid Lymphocytosis
Authors: Vieira José Pedro , Brito Maria João , de Carvalho Isabel Lopes
Published: June 2019

Headache with neurologic deficits and cerebrospinal fluid lymphocytosis (HaNDL) is a rare headache syndrome included in the Classification of Headache of the International Headache Society as a “headache attributed to non-infectious inflammatory intracranial disease.”

We report one 15-year-old patient with clinical history and cerebrospinal fluid findings compatible with the diagnosis of HaNDL in whom Borrelia lusitaniae was identified in cerebrospinal fluid by polymerase chain reaction.
Maximum Norepinephrine Dosage Within 24 Hours as an Indicator of Refractory Septic Shock: A Retrospective Study
Authors: Kasugai Daisuke , Hirakawa Akihiko , Ozaki Masuyuki , Nishida Kazuki , Ikeda Takao , Takahashi Kunihiko , Matsui Shigeyuki , Uenishi Norimichi
Published: June 2019

Background:

The management of refractory septic shock remains a major challenge in critical care and its early indicators are not fully understood. We hypothesized that the maximum norepinephrine dosage within 24 hours of intensive care unit (ICU) admission may be a useful indicator of early mortality in patients with septic shock.

Methods:

In this retrospective single-center observational study, patients with septic shock admitted to the emergency ICU of an academic medical center between April 2011 and March 2017 were included. Individuals with cardiac arrest and those with do-not-resuscitate orders before admission were excluded. We analyzed if the maximum norepinephrine dosage within 24 hours of ICU admission (MD24) was associated with 7-day mortality.

Results:

Among 152 patients with septic shock, 20 (15%) did not survive by day 7. The receiver operating characteristic curve analysis for predicting 7-day mortality revealed a cutoff of MD24 of 0.6 μg/kg/min (sensitivity 47%, specificity 93%). In the multivariable regression analysis, a higher MD24 was significantly associated with 7-day mortality (odds ratio: 7.20; 95% confidence interval [CI]: 2.02-25.7; P = .002) but not with 30-day mortality. Using the inverse probability of treatment weighting method in a propensity scoring analysis, a higher MD24 was significantly associated with 7-day (hazard ratio [HR]: 8.9; 95% CI: 3.2-25.0; P < .001) and 30-day mortality (HR: 2.7; 95% CI: 1.2-5.8; P = .012).

Conclusions:

An MD24 ≥0.6 μg/kg/min was significantly associated with 7-day mortality in patients with septic shock and may therefore be a useful indicator of refractory septic shock.
Beyond the Albanian–Slav Divide: Political Cooperation and National Identities in the Balkans at the Turn of the Twentieth Century
Authors: Bego Fabio
Published: June 2019

This article investigates how some prominent and less known Albanian activists perceived their Southern Slav neighbors at the turn of the twentieth century. The research explores the way in which the spread of nationalism conditioned the positioning of Albanians and Slavs in the process of identity construction and how such identities mirrored their reciprocal political claims. Recent scholarship has often emphasized that the affirmation of national ideas led to the fragmentation of Balkan communities by turning Albanian-speaking populations and their Slavic-speaking neighbors into “others.” My analysis expands this assertion by elaborating a theoretical approach that allows us to explore the impact of nationalism on the post-1878 Balkan context from a more dynamic point of view. National discourses did not only lay the foundation for a differentiation between the Balkan communities, but were also tools for promoting joint political activism. National activists often felt it necessary to cooperate in order to deal with the challenges posed by the surrounding environment, which was common to both Albanians and Slavs. Various contingent circumstances led Albanian activists to project long-term forms of coexistence with their neighbors, and to imagine forms of political, cultural, and social synthesis with the Slavs.
Interaction Between Cyclosporine and Palbociclib in a Renal Transplant Patient: Case Report and Pharmacokinetic Perspective
Authors: Momper Jeremiah D. , Yang Jin , Kerr Janice , Saunders Ila , Smith Jennifer , Shah Mita M.
Published: June 2019

Solid organ transplant recipients have increased cancer risk due in part to chronic immunosuppression and opportunistic oncogenic viral infections. The management of drug interactions in transplant recipients being treated for cancer is important both to minimize the likelihood of drug-related toxicities and to optimize therapeutic outcomes. We present a case of a 41-year-old woman with a stable living–related kidney transplant maintained on an immunosuppressive regimen of cyclosporine, mycophenolate mofetil, and prednisone, who was subsequently diagnosed with a metastatic lobular breast carcinoma and papillary thyroid cancer and started palbociclib, a time-dependent CYP3A inhibitor. After initiation of palbociclib, cyclosporine trough and peak concentrations were increased by 159% and 81%, respectively, relative to the average cyclosporine concentrations pre-palbociclib. Using the Drug Interaction Probability Scale (DIPS), the interaction between palbociclib and cyclosporine was rated as “probable.” Dose reductions of immunosuppressive agents that are CYP3A substrates are warranted if palbociclib is initiated, followed by close monitoring of blood concentrations. This report also highlights the challenges of coadministering a time-dependent inhibitor with a narrow therapeutic index drug that is metabolized by the same enzyme, particularly when the inhibitor is given in cycles with off-treatment periods.
Gene Replacement Therapy: A Primer for the Health-system Pharmacist
Authors: Petrich John , Marchese Dominic , Jenkins Chris , Storey Michael , Blind Jill
Published: June 2019

Purpose:

Comprehensive review of gene replacement therapy with guidance and expert opinion on handling and administration for pharmacists.

There are currently ∼2600 gene therapy clinical trials worldwide and 4 Food and Drug Administration (FDA)-approved gene therapy products available in the United States. Gene therapy and its handling are different from other drugs; however, there is a lack of guidance from the National Institutes of Health (NIH), FDA, Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), and professional associations regarding their pharmaceutical application. Although the NIH stratifies the backbone biologicals of viral vectors in gene therapies into risk groups, incomplete information regarding minimization of exposure and reduction of risk exists. In the absence of defined guidance, individual institutions develop their own policies and procedures, which often differ and are often outdated. This review provides expert opinion on the role of pharmacists in institutional preparedness, as well as gene therapy handling and administration. A suggested infrastructural model for gene replacement therapy handling is described, including requisite equipment acquisition and standard operating procedure development. Personnel, patient, and caregiver education and training are discussed.

Conclusion:

Pharmacists have a key role in the proper handling and general management of gene replacement therapies, identifying risk level, establishing infrastructure, and developing adequate policies and protocols, particularly in the absence of consensus guidelines for the handling and transport of gene replacement therapies.
Statin-Associated Bilateral Foot Myopathy
Authors: Baggett Mary Caitlin , Nykamp Diane
Published: June 2019

Objective:

To report a case of statin-induced bilateral foot myopathy that resulted from 2 different statins. Case Summary: A 44-year-old Caucasian male with a history of ventricular fibrillation cardiac arrest, hyperlipidemia, and coronary artery disease experienced bilateral foot pain, weakness, and soreness while taking atorvastatin 20 mg daily. The pain subsided within weeks of discontinuing atorvastatin but returned years later after the initiation of rosuvastatin. The Naranjo probability scale indicates that this is a definite association between bilateral foot myopathy and statin use.

Discussion:

There is an association with statin use and lowering cardiovascular risk in patients with dyslipidemia and cardiovascular disease. However, statin metabolites can accumulate in the myocytes of muscle groups to cause a common side effect of myopathy. Statin myopathy typically occurs in large, bilateral, or proximal muscle groups, such as the thighs, back, calves, or buttocks. This patient was unusual in that his muscle symptoms only occurred in his feet and was severe enough to affect his ambulation.

Conclusion:

Stain-associated muscle symptoms have been reported to lessen medication adherence. There is also a risk with muscle symptoms that the patient could develop rhabdomyolysis, a rare but serious condition. Recognizing statin-associated muscle symptoms even in uncommon locations is important, so that alternative lipid-lowering strategies can be implemented to lower cardiovascular risk.
Integrating professionals in French multi-professional health homes: Fostering collaboration beyond the walls
Authors: Alrabie Nour
Published: June 2019

Current evidence of the effectiveness of multi-disciplinary co-location for healthcare integration is mixed. This case study investigates a territorial healthcare project that is implemented across four French rural healthcare practices that co-locate multi-disciplinary healthcare practitioners. Two levels of collaboration were identified: (i) local, intra-team collaboration (i.e., care and prevention) and (ii) territorial, inter-team collaboration (i.e., patient therapeutic education and knowledge sharing). An analysis of 50 interviews with healthcare professionals uncovers important aspects of successful multi-disciplinary collaboration, which is an intermediary between co-location and care integration. By highlighting the social dimension of care integration, with a specific focus on the professional component of interpersonal integration, this study expands the theory of care integration by identifying three antecedents of multi-disciplinary collaboration: (i) prior general practitioner joint-practice experience, (ii) professional impetus (i.e., initiated by practitioners) and (iii) general practitioner peer group membership. Successful multi-disciplinary co-location and, in turn, collaboration offer a range of benefits to both patients and practitioners and advance progress towards promising perspectives, such as local competence transfer and territorial contagion.
What Christian Environmental Ethics Can Learn from Stewardship’s Critics and Competitors
Authors: Simmons Frederick V.
Published: June 2019

In this article I distill a trio of lessons for Christian environmental ethics from the stewardship model’s detractors and rivals. I begin by delineating stewardship and explaining the model’s initial prevalence as Christians’ primary response to widespread recognition of environmental crisis and their faith’s alleged culpability for it. I then distinguish two waves of criticism that, by denouncing stewardship’s substance and method, thoroughly discredited the model among Christian ethicists. Yet, as stewardship was being rejected for its susceptibility to anthropocentrism, one of its chief competitors—the land ethic—was being repudiated for its liability to misanthropy. I argue that these developments give Christians cause to (1) affirm a hierarchical non-anthropocentrism that prioritizes human interests; (2) premise such priority in part on human embrace of non-anthropocentrism; and (3) interpret environmental ethics as more than a matter of models like stewardship.
Comparison of depth cameras for three-dimensional reconstruction in medicine
Authors: Chiu Chuang-Yuan , Thelwell Michael , Senior Terry , Choppin Simon , Hart John , Wheat Jon
Published: June 2019

KinectFusion is a typical three-dimensional reconstruction technique which enables generation of individual three-dimensional human models from consumer depth cameras for understanding body shapes. The aim of this study was to compare three-dimensional reconstruction results obtained using KinectFusion from data collected with two different types of depth camera (time-of-flight and stereoscopic cameras) and compare these results with those of a commercial three-dimensional scanning system to determine which type of depth camera gives improved reconstruction. Torso mannequins and machined aluminium cylinders were used as the test objects for this study. Two depth cameras, Microsoft Kinect V2 and Intel Realsense D435, were selected as the representatives of time-of-flight and stereoscopic cameras, respectively, to capture scan data for the reconstruction of three-dimensional point clouds by KinectFusion techniques. The results showed that both time-of-flight and stereoscopic cameras, using the developed rotating camera rig, provided repeatable body scanning data with minimal operator-induced error. However, the time-of-flight camera generated more accurate three-dimensional point clouds than the stereoscopic sensor. Thus, this suggests that applications requiring the generation of accurate three-dimensional human models by KinectFusion techniques should consider using a time-of-flight camera, such as the Microsoft Kinect V2, as the image capturing sensor.
The concept of socio-environmental transformations in prehistoric and archaic societies in the Holocene: An introduction to the special issue
Authors: Müller Johannes , Kirleis Wiebke
Published: June 2019

Transformations of human societies and environments are closely interwoven. Due to improved possibilities of paleoecological reconstruction and archaeological methods, we are now in a position to empirically collect detailed data from a variety of records. The Collaborative Research Centre 1266 ‘Scales of Transformation’ has developed a concept in which both deductive and inductive transformation dimensions are compared on different temporal and spatial scales. This concept includes the connection between the environmental and social spheres, which are often inseparable. Accordingly, a holistic principle of socio-environmental research is developed, which is exemplified by the contributions to this special issue of The Holocene.
Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from Porcine Mesenchymal Stem Cells
Authors: Conley Sabena M. , Shook John E. , Zhu Xiang-Yang , Eirin Alfonso , Jordan Kyra L. , Woollard John R. , Isik Busra , Hickson LaTonya J. , Puranik Amrutesh S. , Lerman Lilach O.
Published: June 2019

Mesenchymal stromal/stem cells (MSCs) belong to the endogenous cellular reparative system, and can be used exogenously in cell-based therapy. MSCs release extracellular vesicles (EVs), including exosomes and microvesicles, which mediate some of their therapeutic activity through intercellular communication. We have previously demonstrated that metabolic syndrome (MetS) modifies the cargo packed within swine EV, but whether it influences their phenotypical characteristics remains unclear. This study tested the hypothesis that MetS shifts the size distribution of MSC-derived EVs. Adipose tissue-derived MSC-EV subpopulations from Lean ( n = 6) and MetS ( n = 6) pigs were characterized for number and size using nanoparticle-tracking analysis, flow cytometry, and transmission electron microscopy. Expression of exosomal genes was determined using next-generation RNA-sequencing (RNA-seq). The number of EV released from Lean and MetS pig MSCs was similar, yet MetS-MSCs yielded a higher proportion of small-size EVs (202.4 ± 17.7 nm vs. 280.3 ± 15.1 nm), consistent with exosomes. RNA-seq showed that their EVs were enriched with exosomal markers. Lysosomal activity remained unaltered in MetS-MSCs. Therefore, MetS alters the size distribution of MSC-derived EVs in favor of exosome release. These observations may reflect MSC injury and membrane recycling in MetS or increased expulsion of waste products, and may have important implications for development of adequate cell-based treatments.
CSR, Trust, Brand Loyalty and Brand Equity: Empirical Evidences from Sportswear Industry in the NCR Region of India
Authors: Sharma Rajesh , Jain Vranda
Published: June 2019

This study is aimed towards understanding the effect of perceived CSR initiatives (PCSRI) on brand loyalty, and consumer based brand equity (CBBE) in Indian sportswear market. This study was conducted on a group of respondents in Delhi NCR region. Different categories of sportswear brands were chosen for an adequate representation of market share, price and country of origin. The findings indicate that positive and direct relationships exist between PCSRI and consumer trust, PCSRI and brand loyalty; PCSRI and CBBE; consumer trust and brand loyalty; consumer trust and CBBE; brand loyalty and CBBE. The study contributes to the existing literature in understanding the role of PCSRI in building brand loyalty, consumer trust and CBBE. The study will help managers in implementing action plans for enhancing brand loyalty and CBBE in Indian sportswear industry.
“Doing Men’s Jobs”: A Commentary on Work–Life Balance Issues Among Women in Engineering and Technology
Authors: Maji Sucharita
Published: June 2019

Despite a steep increase in female representation in the workforce in the last decade, the gendered division of labour in the family remains broadly unaltered. Women, even who work for the same duration as their husbands in the office and contribute equally or more to the financial status of the family, often take most of the shares of childcare responsibility and domestic work. Work–family conflict is a global problem for working men and women; the struggle is even more prominent among working women, especially those who work in male-dominated sectors such as engineering and technology. Working in gender-atypical professions, females in engineering and technology face solo status and experience perceived discrimination and social identity threat. They require to put additional efforts to adjust to the work environment which, in turn, impacts their work–life balance status. The gendered work culture in engineering and technology sectors is reported to be masculine and patrifocal as a result of the skewed sex-ratio. Moreover, the study attempted to find out how the gender-role perception and identification of them, gender stigma consciousness, and role conflict may further aggravate the work–family conflicts among women engineers. In addition, the added responsibilities and conflicts that come with motherhood and their impacts on the work–life balance are discussed.
Ecocentric Education: Student Reflections on Anthropocentrism–Ecocentrism Continuum and Justice
Authors: Kopnina Helen
Published: June 2019

This article discusses liberal arts college students’ perceptions of environmental and ecological justice. Complementing emerging studies of education that tackles human–environment relationships, this article discusses student assignments related to the debates in social/environmental and ecological justice written as part of the course ‘Environment and Development’. Student assignments are analysed with the aim of gauging their view on the environment and society, identifying reasoning patterns about the anthropocentrism–ecocentrism continuum. In conclusion, this article distills recommendations for the design of a university curriculum that can facilitate the development of a non-anthropocentric worldview.
Socio-economically Substantiated Education for Sustainable Development: Development of Competencies and Value Orientations Between Individual Responsibility and Structural Transformation
Authors: Schank Christoph , Rieckmann Marco
Published: June 2019

In this article, the concept of education for sustainable development is substantiated and expanded upon from a socio-economic perspective. Incorporating the concept of the economic citizen, we present the liberal republican civic ethos, moral judgement, decision-making capabilities and key competencies relevant for sustainability together with an informed understanding of economic context as constitutive elements of the educational concept. Against the backdrop of the limited reach of individual behavioural changes and the necessary reflections on structural questions, a heuristic of shared responsibility for sustainable development will be devised.
Effect of Composition of Board and Promoter Group Retained Ownership on Underpricing of Indian IPO firms: An Empirical Study
Authors: Anand Ramit , Singh Balwinder
Published: June 2019

The present empirical investigation is an addition to the existing extant literature available on the issue of initial public offering (IPO) which sees its inherent anomaly of underpricing by linking it to some of under-researched dimensions of corporate governance in the emerging economy of India. This study incorporates about 443 Indian IPO firms with their board composition and ownership retained by promoter group post IPO being primary variables of focus which are obtained from respective prospectuses of such firms. Like many previous studies, this study also keeps signalling theory as base, and findings show that only interlocking of directors among all the board variables has a significant and negative relation with underpricing. Significant relation of ownership concentration in hands of promoter group with underpricing shows that it is considered as a signal by investors assisting them in gauging safety of their minority interests. Findings show that too high insiders’ ownership alignment of interest between promoters and minority holders turn into risk of entrenchment by initial investors, that is, promoters as perceived by investors.
CPEC, Afghanistan and India’s Concerns
Authors: Manish  , Kaushik Prashant
Published: June 2019

This paper highlights China’s views regarding CPEC and argues that stakes are very high for China in CPEC, and it is a project that must succeed if BRI is to go down in history as a success. However, CPEC’s success cannot be ensured without responding to the security challenge present in Pakistan and Afghanistan, which has the potential to jeopardise the CPEC and as a result the entire BRI. Hence, China is required to engage with both Pakistan and Afghanistan to ensure the long-term security of the CPEC. Building of CPEC and its further extension leaves India with limited options but augmenting economic, political and security concerns.
Book review: C. V. Ranganathan and Sanjeev Kumar (Eds), China and the Eurasian Region: Geographic and Geopolitical Influences
Authors: Singh Prashant Kumar
Published: June 2019

C. V. Ranganathan and Sanjeev Kumar (Eds), China and the Eurasian Region: Geographic and Geopolitical Influences. New Delhi: ICWA, 2018, pp. i–xxii + 1–301, ₹995. ISBN: 978-93-83445-31-8.
Book review: Avtar Singh Bhasin, India and Pakistan: Neighbours at Odds
Authors: Behera Ajay Darshan
Published: June 2019

Avtar Singh Bhasin, India and Pakistan: Neighbours at Odds. New Delhi: Bloomsbury India, 2018, pp. 514, INR 599. ISBN: 978-93-86826-20-6.
Malignant Leydig cell tumor in dogs: two cases and a review of the literature
Authors: Kudo Tomoo , Kamiie Junichi , Aihara Naoyuki , Doi Masaki , Sumi Ayumi , Omachi Tetsuo , Shirota Kinji
Published: June 2019

Malignant Leydig cell tumor (MLCT) is a rare testicular tumor in dogs. We report herein 2 dogs with MLCT and cutaneous metastasis. Grossly, marked enlargement and distortion of the involved testes were noted; on cut surface, the parenchyma was completely replaced by neoplastic tissue. In addition, these tumors had extensive necrosis and hemorrhage. Case 1 had a rapidly growing cutaneous mass in the left angle of the mouth; the lesion was well-circumscribed and had an indistinct lobular pattern. Case 2 had multiple cutaneous masses in the dorsal neck region, the thoracic back region, and the right hindlimb. Microscopically, the tumor lobules were composed of oval-to-polyhedral cells with eosinophilic cytoplasm and resembled testicular tumors. By immunohistochemistry, the neoplastic cells in both the testicular and cutaneous tumors were positive for inhibin-alpha and melan A. The mitotic counts of the primary tumors from cases 1 and 2 were 21 and 11 per 10 high-power fields, respectively. Based on these findings, the cases were diagnosed as MLCT with cutaneous metastasis. Ki-67 expression in the neoplastic cells of the 2 cases was higher than in benign Leydig cell tumors. Our findings may be helpful for the diagnosis of canine MLCT.
Leadership Team Components Leading to Implementation Success: An Exploratory Study
Authors: Judkins Maryann , Bosworth Kris , Garcia Rafael
Published: June 2019

Facilitating change in schools requires the leadership, time, and skills of a number of educators in the school community. While the principal usually initiates change activities such as implementing a new program or initiative or reform, the planning and the daily monitoring of the implementation becomes the purview of teams of school personnel. By sharing or distributing the leadership responsibilities, engagement and commitment to the intended change increases as does the likelihood of success. Although much has been written about the importance of teams to program implementation and school outcomes, less is known about the specific contribution of a team’s organization, leadership capacity, or processes. This exploratory study examines these components of leadership teams at 19 high schools implementing School-wide Positive Behavior Interventions and Supports (SW-PBIS). We found that team functioning was significantly associated with program implementation of SW-PBIS. Additionally, we found that the process component was significantly associated with implementation fidelity, organization had a weak association, and leadership capacity had no association. Implications for practice and future research are discussed.
Predictors of Self-Efficacy in Administering Insulin Injection
Authors: Huang Mei-Chuan , Hung Chich-Hsiu , Huang Ya-Wen , Yang Su-Ching
Published: June 2019

This study aimed to identify the predictors of self-efficacy in administering insulin injection among patients with type 2 diabetes. Using a cross-sectional survey, data were collected via purposive sampling from a metabolic ward of a medical center in Southern Taiwan. Participants were 72 patients with type 2 diabetes, who had started using Lantus, Levemir, or Novomix pen injectors. Data were collected from October 2013 to August 2014, using the Diabetes and Insulin Injection Knowledge Scale, Self-Efficacy in Administering Insulin Injection Scale, and photographs illustrating insulin injection skills. The findings indicated that “knowledge of diabetes and insulin injection,” “insulin injection skills,” “senior high school or above education,” and “diabetes duration” were predictors of self-efficacy in administering insulin injection, which explained 41% of the total variance in self-efficacy. Health care professionals can design relevant strategies for improving patient self-efficacy in administering insulin injection, thereby increasing patients’ insulin self-injection abilities.
Experiential Learning Through Local Implementation of a National Chief Resident in Quality and Patient Safety Curriculum
Authors: Ronan Matthew V. , Menon Aravind , Swamy Lakshman , Thornton David
Published: June 2019

The Clinical Learning Environment Review was created to evaluate quality improvement and patient safety (QIPS) beginning in 2013. Little guidance has been offered on implementing QIPS curricula for residency education. The aim was to provide a model QIPS residency curriculum from VA Boston Healthcare System (VABHS), wherein a chief resident in quality and patient safety (CRQS) participates in a national curriculum implementing skills and concepts locally. The CRQS mentors a patient safety resident with faculty oversight. The program involves case investigations, educational conferences, and experiential learning. Participants are residents from Beth Israel Deaconess Medical Center, Boston Medical Center, and Brigham and Women’s Hospital and medical students from Boston University Medical School and Harvard Medical School. Local and national CRQS programs are evaluated. The patient safety rotation is evaluated locally. The local curriculum at VABHS augments the national curriculum and deploys a patient safety education that develops experiential learning skills.
Effectiveness of Statins as Primary Prevention in People With Gout: A Population-Based Cohort Study
Authors: Garcia-Gil Maria , Comas-Cufí Marc , Ramos Rafel , Martí Ruth , Alves-Cabratosa Lia , Parramon Dídac , Prieto-Alhambra Daniel , Baena-Díez Jose Miguel , Salvador-González Betlem , Elosua Roberto , Dégano Irene R. , Marrugat Jaume , Grau María
Published: June 2019

Background:

Cardiovascular guidelines do not give firm recommendations on statin therapy in patients with gout because evidence is lacking.

Aim:

To analyze the effectiveness of statin therapy in primary prevention of coronary heart disease (CHD), ischemic stroke (IS), and all-cause mortality in a population with gout.

Methods:

A retrospective cohort study (July 2006 to December 2017) based on Information System for the Development of Research in Primary Care (SIDIAPQ), a research-quality database of electronic medical records, included primary care patients (aged 35-85 years) without previous cardiovascular disease (CVD). Participants were categorized as nonusers or new users of statins (defined as receiving statins for the first time during the study period). Index date was first statin invoicing for new users and randomly assigned to nonusers. The groups were compared for the incidence of CHD, IS, and all-cause mortality, using Cox proportional hazards modeling adjusted for propensity score.

Results:

Between July 2006 and December 2008, 8018 individuals were included; 736 (9.1%) were new users of statins. Median follow-up was 9.8 years. Crude incidence of CHD was 8.16 (95% confidence interval [CI]: 6.25-10.65) and 6.56 (95% CI: 5.85-7.36) events per 1000 person-years in new users and nonusers, respectively. Hazard ratios were 0.84 (95% CI: 0.60-1.19) for CHD, 0.68 (0.44-1.05) for IS, and 0.87 (0.67-1.12) for all-cause mortality. Hazard for diabetes was 1.27 (0.99-1.63).

Conclusions:

Statin therapy was not associated with a clinically significant decrease in CHD. Despite higher risk of CVD in gout populations compared to general population, patients with gout from a primary prevention population with a low-to-intermediate incidence of CHD should be evaluated according to their cardiovascular risk assessment, lifestyle recommendations, and preferences, in line with recent European League Against Rheumatism recommendations.
Retrospective Autoethnographies: A Call for Decolonial Imaginings for the New University
Authors: Bell Deanne , Canham Hugo , Dutta Urmitapa , Fernández Jesica Siham
Published: June 2019

In this article, we present “retrospective autoethnographies” as a methodology for decolonial inquiry/intervention in the context of neoliberal settings, specifically the university. Autoethnography represents that epistemic and methodological space where the personal intersects with the political, historical, and cultural to critique everyday power structures. Instead of inserting the autobiographical past into the present, we write of our present and our desire for a utopian future to begin to create an image of the New University. Together, as people raised in the postcolony and within coloniality, we begin at the negative affect as neoliberal universities invisibilize, surveil, audit, and discipline—but then, we strive to imagine a New University characterized by radical hope, doing so alongside student movements pushing for decolonizing the university. This article is envisioned as an exhortation for a decolonial intervention of radically dreaming the New University into place.
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Authors: Ghosh Hiyaa S
Published: June 2019

The adult brain, even though largely postmitotic, is now known to have dividing cells that can make both glia and neurons. Of these, the precursor cells that have the potential to make new neurons in the adult brain have attracted great attention from researchers, anticipating their therapeutic potential for neurodegenerative conditions. In this review, I will focus on adult neurogenesis, from the perspective of the overall neurogenic potential in the adult brain, current understanding of the ‘adult neural stem cell’, and the importance of niche as a decisive factor for neurogenesis under homeostasis and pathologic conditions.
Socially inclusive practices in the music classroom: The impact of music education used as a vehicle to engage refugee background students
Authors: Crawford Renée
Published: June 2019

As schools become increasingly culturally diverse, globalisation and cross-cultural exchange challenge teachers in complex but exciting ways. This article reports on the impact of music education for students in a secondary school in Victoria, Australia. Socially inclusive practices were a focus of the study as the school has a high percentage of young people with a refugee background. A number of school-based musical experiences provided opportunities for cross-cultural exchange and negotiation, and diverse communications are described. Music education was used as a vehicle to engage young refugee background students, which was indicative of three primary themes: personal wellbeing, social inclusion (a sense of belonging), and an enhanced engagement with learning. Key findings from this case study research indicated that a music classroom which fostered socially inclusive practices resulted in a positive transcultural learning space. This research raises important questions about the critical role of music education and the arts in contemporary and culturally diverse school contexts.
Do contextual factors matter? Evidence from Chinese hotel productivity with heterogeneity
Authors: Dong Hai , Peypoch Nicolas , Zhang Linjia
Published: June 2019

In this article, an assessment of efficiency and productivity of Chinese hotels at the provincial level in relation to their star rating is proposed. This heterogeneity is considered by using a hierarchical structure. The drivers of productivity and its components are studied through various and innovative environmental and contextual factors. This study shows that Chinese star-rated hotels experienced a slight productivity deterioration in the last decade. Furthermore, several contextual and environmental factors explain significant differences in productivity rankings of the Chinese provinces. These findings reveal important patterns that are useful for both hotel managers and policymakers.
The effect of the Las Vegas Strip on hotel prices: A hedonic approach
Authors: Conroy Stephen J , Toma Nicholas , Gibson Gregory P
Published: June 2019

The authors investigate the effect of location on the nightly hotel room rates charged in Las Vegas. Using a hedonic estimation approach, the authors control for room amenities and hotel and time characteristics. Including 6087 hotel room nights for hotels located near the Las Vegas Strip in two different years (2012 and 2017), the authors estimate the relationship between hotel location and nightly room rates. Consistent with prior investigations, the authors find strong evidence for the effect of location, amenities, and day of week on hotel prices, with a “Strip premium” of 40.21% (US$106.85 at the mean hotel price) for hotels located within 0.25 miles of the Las Vegas Strip compared to hotels beyond 0.75 miles of the Strip. They estimate a Center-of-Strip premium of 70.23% (US$186.61 at the mean hotel price) for hotels located within 0.75 miles, 36.89% (US$98.01) for the next 0.75 miles, and 18.89% (US$50.18) for the next 0.75 miles, compared to hotels beyond 2.25 miles.