bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuro-Linguistic Programming: The Application in Offline and Online Classes
Authors: Soethama Putu Lirishati , Sumaryana I Komang
Published: March 2024

Neuro-Liguistic Programming (NLP), proposed by Richard Bandler and John Grinder in the 1970s, is one of the most effective and useful methodologies to help us communicate effectively in various areas of life such as corporate environment, college life, education, marketing, health, and various other areas. This method is indispensable in the teaching and learning process and can accommodate the very fast and sudden changes that occurred due to the pandemic situation. In this study, the NLP effective techniques: of creating rapport, mirroring, creating positive states and anchoring, maintaining flow, pacing and leading, perceptual positioning, and modeling good practice were used in online and offline lecturing. These techniques were applied to strengthen the three learning styles visual, auditory, and kinesthetic. The data were collected through observation and field research methods. Forty (40) students from two (2) online classes and two (2) offline classes, namely Debating on Recent Issues and Theory of Literature and Literary Criticism Class participated in this study. A survey has been given by the end of each lecture to measure the success of the NLP techniques applied by the lecturer. Results showed differences between online and offline classes. Its success decreased in online classes. Therefore, the development of material delivery techniques is needed to be more developed in online classes, especially in visual presentation models to patch up the missing kinesthetic models in online classes.
The Influence of Promotion and Service Quality on Satisfaction and Its Impact on Tourist Loyalty in Historical Tourism Objects
Authors: Rahayu Sri , Nurahmi Maftuha , Samsuddin Widi
Published: March 2024

Purpose: This study aims to determine whether promotion and service quality influence satisfaction and Impact tourist loyalty to South Sumatra Province's historical attractions.
 
Theoretical Framework: This unique blend of historical significance and ongoing cultural relevance holds the potential to evolve into a scheduled tourist destination and stimulate the development of a vibrant village community around the temple.
 
Methods: This type of research is associative. The sample in this study were tourists at historical attractions in the province of South Sumatra, especially the Bala Putra Dewa Museum and Ayu Temple, which amounted to 220 people. This study uses primary data.
 
Results and Conclusion: The study results show a significant positive effect of promotion on tourist satisfaction at historical attractions in South Sumatra Province. Service quality has a significant positive effect on tourist satisfaction at historical attractions in South Sumatra Province. Promoting significantly positively affects tourist loyalty to historical tourism objects in South Sumatra Province.
 
Research implications: The act of actively participating in museum displays and informational materials provides individuals of all ages, including both children and adults, with a pleasurable and immersive opportunity for informal education. This engagement allows people to enhance their comprehension of the cultural, traditional, or historical elements associated with a particular area.
 
Originality/value: The Service quality has a significant positive effect on tourist loyalty to historical tourist objects in South Sumatra Province. There is a significant positive effect on satisfaction on tourist loyalty to historical tourism objects in South Sumatra Province.
Interpersonal Relationships in First Level Care Workers of The Ministry of Health, Breña District, 2022
Authors: Espinoza Jessica Inga , Flores Miguel Vera
Published: March 2024

Purpose: Determine the level of interpersonal relationships of the health worker at the first level of care in the Breña District in the year 2022.
 
Theoretical framework: Good treatment, which is given and received, is the way we proceed or act when relating to another human being, group or organization, whether by deed or omission, physically or verbally, etc.
 
Material and Methods: The present study is descriptive, retrospective and cross-sectional, in 68 health workers. The survey on interpersonal relationships by Muñoz (2015) was applied.
 
Results and Conclusions: Confirmatory factor analysis was applied to obtain the construct validity of the instrument, meeting the requirements: Kaiser-Meyer-Olkin (KMO) index of 0.811 (>0.7) and Bartlett test with a significance value of 0.00 < 0.05. In the health workers of the Breña district, a high level is observed 19.1%, a medium level 77.9% and a low level 2.9%. Considering the 3 dimensions, the medium level varies between 59.4% to 80.6% and in terms of proportions, in second place stands out the high level whose values vary between 16.7% and 34.4%.
 
Research implications: The instrument showed evidence of construct validity and reliability, and these analyzes indicate the feasibility of the instrument proposed by Muñoz, who distributed the 18 items in three dimensions: attitude, treatment and communication, considering 6 items for each one.
 
Originality/value:  It is important to establish adequate interpersonal relationships based on fluid communication that will contribute to the fulfillment of the institution's objectives focused on achieving of health indicators and achieve quality care.
Legislation and spiritual and moral security of the Russian Federation: mechanisms of preservation, protection and constitutionalization
Authors:   Southern Federal University, Alexey I. Ovchinnikov ,   Don Theological Seminary
Published: March 2024

The article is devoted to the consideration of mechanisms for the preservation and protection of traditional spiritual and moral values. The author notes that the adoption of the Decree of the President of the Russian Federation dated 11/19/2022 No. 809 "On Approval of the Foundations of State Policy for the preservation and strengthening of traditional Russian spiritual and moral values" is an important stage in the development of the Russian state and legal system, taking into account its socio-cultural, civilizational background. The emphasis is placed on the fact that the Constitution of the Russian Federation unequivocally prohibits the establishment of a state or mandatory ideology, there are no barriers to the presence of a public ideology in the state. According to the author, it is necessary to consolidate the concept of "traditional spiritual and moral values" in the legislation by making a number of changes to existing normative legal acts. According to the author, the legislation of the Russian Federation should develop along the path of integration of law and morality. A certain set of measures is required to institutionalize state support and protection of traditional spiritual and moral values. To date, there is a legally extremely significant gap in the definition of the concept of "public morality". Ensuring spiritual and moral security and protecting spiritual and moral human rights must be legislatively defined as a priority task of the State. According to the author, the main task of the state today is to preserve the family and the strength of marriage as the basic value of society and the state. The family, as a priority value, should be enshrined in a special federal law, providing this state-forming institution with special guarantees for the realization of the right to a decent existence, cultural and moral security, upbringing and education of children in traditional spiritual traditions.
Rendimiento de la educación en las regiones colombianas: un análisis usando la Descomposición Oaxaca-Blinder
Authors: Quiñones Domínguez Mauricio , Rodríguez Sinisterra Juan Antonio
Published: March 2024

Teniendo como referente la teoría del capital humano se examinan las diferencias regionales, como indicador de las variaciones en los ingresos de los individuos pertenecientes a ellas. Se utilizaron para este fin estimaciones por Mínimos Cuadrados Ordinarios y la descomposición de Oaxaca-Blinder, corrigiendo el sesgo de selección por el método propuesto por Heckman, usando los datos de la Encuesta Continua de Hogares en el segundo trimestre del 2006 para las trece áreas metropolitanas colombianas. Con Bogotá como región de referencia, se encontró evidencia de cambios en los rendimientos de la educación atribuibles a condiciones regionales, descomponiendo qué proporción corresponde a las dotaciones de Capital Humano y cuál a la condición de pertenencia a la respectiva región.
Salarios reales en Colombia: un análisis de convergencia condicional: 1984-2009
Authors: Galvis Luis Armando
Published: March 2024

Este artículo tiene como objetivo estudiar la convergencia sigma condicional empleando microdatos. Se utilizan las encuestas de hogares de 1984 a 2009 para obtener los salarios de los empleados del sector privado. Con esta información se calcula la contribución que tienen las principales ciudades del país en las desigualdades totales, empleando la descomposición del índice de Theil. Utilizando métodos de remuestreo se construyen intervalos de confianza para el componente interregional de este índice, encontrándose que dicho componente es significativo, y no se reduce a través del tiempo. Por ello, de acuerdo con los resultados del ejercicio se encuentra que no hay evidencia de convergencia sigma condicional. Posteriormente, se evalúan los determinantes micro-económicos de salarios, en un modelo minceriano. Los resultados indican que existen diferenciales significativos, al realizar control con dichos determinantes. Ello se toma como evidencia para rechazar la hipótesis de convergencia sigma condicional en los salarios de las principales ciudades del país.
Evaluación del desempeño económico de los sistemas de pensiones privados en Latinoamérica (1997-2008)
Authors: Duarte Ojeda José Ricardo , Elizalde Sánchez Carlos Cebarut , Casparri María Teresa
Published: March 2024

Los sistemas de pensiones de América Latina han vivido una oleada de reformas sin precedente en la década de los noventas; el pionero es el caso de Chile, que en 1981 ha migrado del sistema de Reparto (PAYGO) al sistema de capitalización individual. Es un contrastante cambio de política de corte neoliberal que ha privatizado las pensiones de los trabajadores, ocasionando una variedad de resultados, en este artículo se analiza el desempeño económico 5 sistemas seleccionados: México, Argentina, Chile, Perú y Bolivia; en un período en el cual se han producido numerosos cambios en el panorama financiero a nivel continental y mundial, que ha afectado el mercado de capitales, desencadenado una de las peores crisis del reformado sistema en 2007-2008.
Reflexiones en torno a la práctica testimonial sobre la experiencia concentracionaria en Argentina
Authors: Messina Luciana
Published: March 2024

En este trabajo me propongo reflexionar en torno a la práctica testimonial sobre la experiencia concentracionaria, mediante la reconstrucción y el análisis del recorrido testimonial de un sobreviviente de un centro clandestino de detención de la última dictadura militar en Argentina (1976-1983). Una de las inquietudes que articula esta reconstrucción es conocer cómo se fue transformando el espacio discursivo testimonial sobre los crímenes del terrorismo de Estado a lo largo de los últimos treinta años. Para ello, pondré en relación la práctica testimonial con las diferentes coyunturas sociales y políticas, atendiendo especialmente a lo dicho y lo silenciado en los testimonios.
Estrategias de la memoria: de lo político a lo cotidiano. Miradas desde el cine documental surcoreano
Authors: Álvarez María Pilar , Manfredi Luciana
Published: March 2024

El presente artículo describe y analiza las formas que adquiere la memoria histórica en el cine documental surcoreano contemporáneo, y su vinculación con los imaginarios sociales y familiares de los documentalistas. El objetivo central es discutir las nuevas tendencias de la memoria histórica en el cine documental surcoreano y su impacto en el debate sobre memoria en imágenes audiovisuales. Para tal fin seleccionamos dos documentales: Cheonggyecheon Medley: A dream of iron (Kelvin Park 2010) y Repatriation (Kim Dong Won 2003), que serán estudiados de manera comparativa en el marco del debate sobre memoria y cine de lo real. Con base en lo observado, nos atrevemos a afirmar que existe una nueva tendencia en el cine surcoreano que muestra cómo la doble funcionalidad de la memoria política, como práctica ideológica-pedagógica y como una necesidad de la vida cotidiana, genera una “zona gris” de memorias en conflicto.
Persistencia del pasado a través de los objetos del presente
Authors: Hernández Romero Yissel
Published: March 2024

El transitar del hombre por el tiempo es un movimiento cuya evidencia solo queda en memoria, evidencia que se diluye lentamente hasta que en algunos casos llega a desaparecer y que sucede tanto en lo individual como en lo colectivo; las huellas, consideradas como evidencias sensibles, superan la intangibilidad y lo efímero de las imágenes mentales al tomar forma escrita, gráfica o material. Socialmente valorado, el pasado puede preservarse, retomarse e incluso reinterpretarse. Este artículo analiza las manifestaciones del pasado a través de la cultura material, la construcción de significados y su persistencia en el presente a través del objeto antiguo, el revival y el diseño retro.
Crónica de una vergüenza: el papel de las autoridades civiles y militares durante la llegada de los paramilitares de las AUC al Valle del Cauca (julio-agosto de 1999)
Authors: González Grisales Adolfo León
Published: March 2024

El 31 de julio de 1999 se registró la primera incursión militar del Bloque Calima de las Autodefensas Unidas de Colombia (AUC), cuando un grupo de hombres uniformados y bien armados se tomaron el corregimiento de La Moralia, en zona montañosa del centro del Valle del Cauca, asesinando a dos de sus habitantes. El presente artículo analiza el papel que desempeñaron las autoridades civiles, militares y de policía de la región, durante los días previos y los que siguieron a este nefasto episodio, con base en los archivos de la prensa local y nacional de los meses de julio y agosto de 1999.
Mujeres cafeteras y los cambios de su rol tradicional
Authors: Valencia Lina María Rodríguez
Published: March 2024

Este artículo presenta los cambios más importantes generados en el rol tradicional de algunasmujeres propietarias de fincas cafeteras en los municipios de Calarcá, Montenegroy Sevilla (Colombia) para el periodo 1970-2011, destacando la incidencia de los métodos deplanificación familiar en las transformaciones femeninas. El análisis aborda las accionesinstitucionales desarrolladas por la Federación Nacional de Cafeteros y Profamilia comoelementos explicativos de los cambios identificados. Es un estudio descriptivo con perspectivahistórica que metodológicamente tuvo una aproximación regional para examinarlos cambios generales dados en la familia y la mujer.
Un fantasma recorre la izquierda nacional. El feminismo de la segunda ola y la lucha política en Argentina en los años setenta
Authors: Trebisacce Catalina
Published: March 2024

La historia de encuentros y desencuentros entre el feminismo y otras luchas socialestiene varias décadas de existencia. Probablemente sea constitutiva del propio feminismo.En el marco del reavivado interés que por este asunto presentan los estudios de interseccionalidadse vuelve necesario recuperar historias del feminismo que pongan atenciónen este punto. El presente trabajo es una contribución a dicha empresa. El mismo analizala experiencia particular que encarnó la izquierda nacional argentina, específicamente elFrente de Izquierda Popular, en pleno proceso de radicalización política y en el contextode la irrupción de la llamada segunda ola del feminismo. El artículo pone en primer planolas apuestas, las dificultades, las marchas y las contramarchas que el Frente IzquierdaNacional debió atravesar en el intento de abrazar la lucha feminista.
Historia del proceso de preimplementación de las dos Reservas Marinas de Interés Pesquero en la isla de Tenerife, Canarias, España
Authors: Rodrigues Henriques Karyn Nancy
Published: March 2024

La diversidad de fines que persiguen las Áreas Marinas Protegidas, remite a la necesidadde analizar los intereses que las justifican y las características que reúnen para alcanzarlos,a fin de prever su utilidad real. Las primeras propuestas de Reservas Marinas enTenerife comenzaron a desarrollarse en los años ochenta; sin embargo, todavía ningunade ellas se ha materializado. Mediante el análisis de fuentes documentales, entrevistas yobservación participante, se rescató el proceso histórico de dichos proyectos con el fin dedetectar las interacciones e iniciativas que contribuyeron al cambio de imágenes, metase intereses a los que respondieron. Los conflictos de interés que emergieron entre losafectados fueron uno de los factores que contribuyeron a prolongar la puesta en marchade las Áreas Marinas Protegidas.
Apuntes para una Ecología Política de la Dependencia. El caso del acaparamiento de tierras
Authors: Costantino Agostina
Published: March 2024

La importancia del problema del acaparamiento de tierras no es sólo en términos de concentraciónde los recursos naturales y exclusión de los mismos de las comunidades locales,sino que el objetivo principal de este acaparamiento es la producción de materias primasy alimentos, cuya forma de producción tiene un fuerte impacto en términos ambientales(degradación del suelo, contaminación, etc.). En este trabajo nos preguntamos sobreel marco interpretativo que permitiría abordar el problema de la orientación selectiva delas inversiones extranjeras en tierras hacia algunos países. Creemos que la condición dedependencia de los mismos es crucial para poder entender este fenómeno. Es por esto queproponemos analizar el problema del acaparamiento de tierras en relación directa con lacondición de dependencia de los países latinoamericanos; en este sentido sugerimos la necesidadde un marco teórico al que denominamos la “Ecología Política de la Dependencia”.
El alegato de la re apropiación de la naturaleza: hacia las nuevas formas biotecnologizadas del capital
Authors: Valdebenito González María Paz
Published: March 2024

Este artículo se propone analizar la relación naturaleza-sociedad en el marco de las nuevasproducciones biotecnológicas, mediante un examen crítico de las intervenciones dela moderna biotecnología en la naturaleza. La biotecnología permite la reinvención delSistema Capitalista en el contexto de una fuerte globalización del ambiente y el requerimientode un añorado equilibrio ecológico. Esta reinvención surge a partir de una reapropiaciónde la naturaleza basada en el conocimiento científico y en una operaciónsimbólica que, mediante el discurso del desarrollo sostenible, resignifica el conceptode naturaleza para dar con su normalización, dominio y capitalización en virtud de lasnecesidades del mercado y el capital.
Instrumentos económicos voluntarios para la conservación: una mirada a su surgimiento y evolución en México
Authors: Rodriguez Karla Juliana , Ávila Foucat Sophie
Published: March 2024

La política pública ambiental en México utiliza instrumentos económicos voluntarioscomo la certificación forestal (CF) y el pago por servicios ambientales (PSA) para avanzaren la conservación de sus recursos naturales. Analizar la evolución de estos instrumentosde política pública permite conocer el contexto en el que se diseñaron y se implementan,lo cual generalmente no se considera para su rediseño y evaluación. Se presenta a continuaciónun análisis del surgimiento, evolución y tendencias actuales, de la CF y PSA,después de dos décadas y una década de implementados. Las entrevistas en profundidadsemi-estructuradas muestran que aunque las directrices internacionales son el principaldetonante de su creación, son instrumentos cuya evolución y tendencias reflejan queMéxico ha logrado parcialmente su consolidación, enfrentando actualmente retos comoel fortalecimiento de las políticas comerciales en el caso de la CF y la superación de ladisyuntiva eficiencia–equidad en el caso de PSA.
Racionalidades del territorio: leyes mineras en dos provincias argentinas
Authors: De la Vega Candela
Published: March 2024

Las políticas estatales sobre el territorio contienen y prescriben específicas racionalidades,es decir, principios generadores de prácticas sociales, códigos de visión, decisión y acciónque se constituyen en criterios esperables, permitidos o legitimados. El presente artículopresenta un análisis comparativo de las convergencias entre las decisiones estatales vigentessobre minería en dos provincias argentinas: Córdoba y La Rioja. La particularidad dela convergencia entre estos dos casos es que en ambas provincias han sancionado leyesprovinciales en sentidos opuestos: mientras en Córdoba rige una ley que prohíbe la actividadminera a cielo abierto, en La Rioja la ley habilitó esta opción. Este artículo fue posiblegracias a un análisis de contenido sobre textos legales y entrevistas a funcionarios públicos.
“Cárcel de mujeres”. Una mirada etnográfica sobre las relaciones afectivas en un establecimiento carcelario de mediana seguridad en Argentina
Authors: Soledad Ojeda Natalia
Published: March 2024

El presente artículo constituye una aproximación a los modos que adopta la afectividaden cárceles de mujeres. Estas reflexiones son producto del trabajo de campo etnográficorealizado en un Instituto Correccional de Argentina que aloja mujeres adultas. Se desarrollaa lo largo del texto una mirada renovada acerca del orden social carcelario, a partirde la comprensión de las afectividades de las detenidas: alianza, amor y solidaridad. Unabordaje de este tipo se contrapone a las perspectivas más tradiciones de la cárcel quela caracterizan como encierro signado exclusivamente por el castigo y la vigilancia institucional.
La gestión de lo social y las formas de intervención en las sociedades de los siglos XX y XXI
Authors: Editorial Comité
Published: March 2024

Lo social en el transcurso de la historia de los siglos XX y XXI en América Latinaha sido un campo heterogéneo tanto de representaciones sobre las desigualdadesy la exclusión, como de las formas como estas se gestionan e intervienenen la arena de las políticas públicas. Dicha heterogeneidad de lo social ha estadopresente no sólo en sus marcos clásicos de regulación fordista y keynesiana—con problemas y grupos sociales inscritos esencialmente en criterios salariales—,sino también en sus actuales preceptos neoliberales —que desplazan lacentralidad del Estado de bienestar y la relación salarial de larga duración, incorporandoprocesos descolectivización, individualización y diversificación de lasdesigualdades y la exclusión—.
Los hospicios y asilos de la Beneficencia de Cundinamarca entre 1917-1928: discursos y prácticas
Authors: Sánchez Salcedo José Fernando
Published: March 2024

El propósito de este trabajo es describir la labor desarrollada por la Beneficencia de Cundinamarca,en los hospicios y los asilos de niños y niñas que estaban bajo su responsabilidadentre 1917-1928. Se hace hincapié en la estructura administrativa, financiera,actores y estrategias de intervención presentes en dichas instituciones. El estudio, que sellevó a cabo, principalmente, a partir de la consulta de diferentes tipos de documentosde la Junta General de Beneficencia, permite identificar las dificultades económicas queatravezaban estos establecimientos y conocer las diferentes estrategias de intervenciónimplementadas para el cuidado y protección de la niñez asilada. Todo esto en el marcode un importante debate sobre la infancia, en el que participaron médicos, pedagogos yjuristas a principios del siglo XX.
Eficiencia en la cobertura del régimen subsidiado de salud: una perspectiva departamental en Colombia
Authors: Botello Peñaloza Hector Alberto
Published: March 2024

Este trabajo evalúa la eficiencia regional en la cobertura del régimen subsidiado de Saluden Colombia entre el 2008 y el 2012, calculando simultáneamente el coste monetarioasociado a esta ineficiencia. Se relacionan datos del ingreso de los individuos con el régimenen el que se encuentran inscritos y estos resultados se cruzan con los presupuestosen salud. Se evidencia que cerca del 17% de las personas dentro de este régimen han sidoincorrectamente identificadas como beneficiarias costando cerca de 350 mil millones depesos o el 22% del presupuesto de salud.
Burbujas financieras: dos alternativas de identificación aplicadas a Colombia
Authors: Uribe Gil Jorge Mario , Ulloa Villegas Inés María
Published: March 2024

Se exploran dos metodologías econométricas para identificar la aparición y el colapso de burbujas en los precios de mercado de tres variables financieras de relevancia para la economía colombiana: la Tasa Representativa del Mercado, el Índice General de la Bolsa de Valores de Colombia y el precio del petróleo. Ambas metodologías se basan en el análisis de integración de las series. La primera toma como referencia el estadístico de signo, un método robusto para la detección de caminatas aleatorias. La segunda se basa en la construcciónde razones de varianzas. Ambas medidas se calculan dinámicamente. Se realizan pruebas de significancia empírica y potencia. Se encuentra evidencia favorable sobre laexistencia de burbujas en los precios de dos variables en períodos recientes.
Artificial intelligence as a tool built into the value system of modern culture
Authors: Belikova Evgeniya Konstantinovna
Published: March 2024

The object of the study is the value system of modern culture; the subject of the research is ways to integrate AI into the modern system of cultural values. The prerequisite is a judgment about the external nature of the changes associated with AI in society, while the value system is internal, fixed in the ideas and beliefs of the individual, formed over the course of life (more than one generation) and difficult to transform. AI acts as a phenomenon of modern culture, which has a value-semantic nature. Its active use in various spheres of life by modern people occurs in conditions when its essence is not fully defined, its capabilities for preserving or transforming the value structure of cultural space have not been established. The research was carried out on the basis of methods of analysis and synthesis, observation, description, etc. Systemic-structural, dialectical, cultural-historical, value-based, interdisciplinary approaches to the problem were used. The scientific novelty of the study lies in the attempt to identify the functions of AI, acting as a cultural phenomenon and influencing cultural values. It is noted that AI, being a relevant and significant cultural phenomenon, undoubtedly affects values, but in different ways. Regarding some values, we can talk about a positive transformation in connection with AI (intelligence and knowledge, science and cognition, equality, collectivism, pleasure, hedonism, success, recognition), regarding others — about a negative one (trust, security), regarding others, which are the majority, — about a complex, ambiguous influence (freedom, preservation of human identity, family, humanistic and spiritual-moral values, health). It is concluded that specialists’ assessment of the nature of the development of the value-semantic structure of AI depends on their level of awareness, as well as on the presence of technophobia.
Application of Mass Particle Methods in the Shape Design for Scientific Balloons
Authors: Zhang Hangyue , Yang Yanchu , Cai Rong
Published: March 2024

This paper proposes a dynamic simulation method for solving balloon shapes. The mass-spring-damping model is used to discretize two-dimensional generatrixes and three-dimensional membrane surfaces, respectively. We solve two-dimensional/three-dimensional ascent shapes at different zero-pressure heights and numerically simulate mushroom cloud shapes that occur during the balloon ground launch. The typical rapid transition feature of the mushroom cloud shape at the waist is depicted. In addition, a preliminary numerical simulation study was conducted for the pumpkin superpressure balloon deployment instability problem. The Calladine instability critical curve for constant angle design lobes is compared and validated for different gore numbers and lobe angles. Further, simulations were carried out on fully inflated shapes of two derived superpressure balloon designs developed by the Japan Aerospace Exploration Agency/Institute of Space and Astronautical Science, namely, the Tawara intermediate cylindrical segment balloon and the diamond-shaped tendon balloon. We verify the ISAS conclusion that the diamond-shaped tendon balloon has a cylindrical shape when fully inflated. Finally, a preliminary simulation study was carried out on the deployment shape of four ballonet architectures in the superpressure balloon. The proposed method for solving various types of balloon shapes based on the mass particle method is simple and efficient, and it has been well applied in our actual balloon engineering.
Nonequilibrium Flow Simulations Using Unified Gas-Kinetic Wave-Particle Method
Authors: Long Wenpei , Wei Yufeng , Xu Kun
Published: March 2024

Nonequilibrium flows are commonly encountered in aerospace engineering applications such as spacecraft reentry, rocket launch, and satellite attitude control. Numerical simulations help greatly in the understanding of nonequilibrium flow, multiscale effects, and the dynamics in these applications. Coupling particle transport and collision within the gas evolution process, the unified gas-kinetic wave-particle (UGKWP) method has been developed for multiscale flow simulation, offering a strategy that strikes a balance between accuracy and efficiency. In the present study, the UGKWP method simulates challenging flow problems with large Knudsen number variations, including supersonic flow around a sphere, hypersonic flow around a space vehicle, nozzle plume into vacuum, and side-jet impingement on the hypersonic flow. The UGKWP accurately captures complex flow structures and has been verified through experimental data or direct simulation Monte Carlo results. Regarding computational cost, the UGKWP method requires only 60 GiB of memory to simulate the three-dimensional space vehicle with 560,593 cells under various flow conditions, which is manageable even on personal workstations. Given its excellent efficiency and accuracy, the UGKWP method shows its substantial benefits in simulating multiscale flow for aerospace engineering applications.
Stable Optimal Feedback Control for Landers Based on Machine Learning
Authors: Mulekar Omkar S. , Cho Hancheol , Bevilacqua Riccardo
Published: March 2024

Stability certification is critical before controllers are rolled out onto real systems. Despite recent progress in the development of neural network systems for feedback-optimal control, enforcement and assessment of the stability of the trained controllers remains an open problem. In this investigation, a comprehensive framework is developed to achieve certifiably stable fuel-optimal feedback control of pinpoint landers in four different formulations of varying complexity. By preconditioning a deep neural network policy and a deep neural network Lyapunov function, and then applying a constrained parameter optimization approach, we are able to address the shape mismatch problem posed by the standard sum-of-squares Lyapunov function and achieve feedback-optimal control. Phase-space plots of the Lyapunov derivative show the level of certificate enforcement achieved by the developed algorithms, and Monte Carlo simulations are performed to demonstrate the stable, optimal, real-time feedback control provided by the policy.
69-Year-Old Female with Progressive Supranuclear Palsy, Frontotemporal Dementia, Focal Hyperkinesia and one variant in the GCH1 gene and in the CSF1R gene
Authors:   Center for Movement Disorders, Parkinson-Klinik Ortenau, Wolfach, Germany, Oikonomou Panteleimon , Hellwig Sabine ,   Department of Psychiatry and Psychotherapy Medical Center - University of Freiburg, Germany, Wehrum Thomas ,   Department of Psychiatry and Psychotherapy Medical Center - University of Freiburg, Germany, Urbach Horst ,   Department of Neuroradiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Germany, Jost Wolfgang H ,   Center for Movement Disorders, Parkinson-Klinik Ortenau, Wolfach, Germany
Published: March 2024

How insignificant is the detection of gene variants in a novel clinical presentation of an atypical Parkinson’s syndrome with positive family history? We present the case of a 69-year-old woman with Progressive Vertical Supranuclear Palsy (PSP), focal hyperkinesia, non-L-dopa-responsive asymmetrical Parkinsonism, postural instability as well as apraxia, cognitive, speech and frontal disorder, with a positive family history, MRI evidence of mesial temporal atrophy and tau-PET evidence of tau pathology as well as identification of one variant in the GCH1 gene and one variant in the CSF1R gene. The fact that the clinical presentation and radiological finding of our patients are not compatible with a known and well described genetic disorder caused by pathogenic mutations of these genes, supports the notion that the detected gene variants have an uncertain significance in the pathogenesis of our patient’s disease. Nevertheless, the novel description of the phenotype of our case of PSP with frontal lobe features, focal hyperkinesia and a positive family history, points to an in-vivo tauopathy, in which a genetic burden may play a role. The follow-up of the patient und her family may offer further insights into the pathophysiology of complex neurodegenerative diseases in the spectrum of tauopathies, offering possible new therapeutic targets.
Nanosensors of Fluorescent Carbon Quantum Dots Derived from Banana Peel: Application in Sr2+ and Co2+ Detection
Authors:   Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran, M Kaffash , A Bakhtparvar ,   Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran, A Rezvani-Noghani ,   Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran, S Hosseini ,   Cancer Research center, Mashhad University of Medical Sciences, Mashhad, Iran, P Mokaberi ,   Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran, J Chamani ,   Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Published: March 2024

Natural Carbon Quantum Dots (NCQDs) are known to contain photo luminescence property and stand as a promising nanomaterial group. Therefore, we intended to generate an intelligible and effective hydrothermal procedure for performing the green synthesis of this material through the usage of banana peel waste as a feasible and durable natural carbon source. The obtained NCQDs were characterized by the means of UV-visible absorption spectroscopy, spectrofluorometry, Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), zeta potential, Atomic Force Microscopy (AFM), Field Emission Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), and Thermo Gravimetric Analysis (TGA). The lack of utilizing any toxic substances has guaranteed the safety of this procedure in all the biological practices. Therefore, the high crystalline and spherical morphology of synthesized NCQDS with an average roughness of about 5.9 nm were indicated by the results of TEM and XRD. We also observed a high water stability and solubility due to the presence of hydroxyl and carboxyl group and excitation- dependent emission performance with the satisfying quantum yield of 12 %. The zeta potential of prepared NCQDs reached up to -27.4 mV. Furthermore, in order to determine the low toxicity and favorable biocompatibility of this product, we studied the toxic effects of NCQDs on the fibroblast cell line of a normal mouse through the MTT assay. In conformity with the gathered data, these NCQDs contain the potential of being utilized as a nontoxic carrier and a fine alternative for bio-sensor, bio-imaging, and drug delivery applications. The development of these NCQDs was completed with the objective of acting as a highly sensitive fluorescent “on-off-on” switch sensor in the course of the selective and simultaneous sensing of Sr2+ and Co2+. Fluorescence data revealed that the binding constants of Sr2+ and Co2+ to NCQDs were to be 1.39 × 104 M-1 and 1.58 × 104 M-1 respectively. The observations were indicative of a linear relationship among the Sr2+ and Co2+ ions volume and the fluorescence intensity throughout the range of 0 to 0.1 mM.
Application of Nanomaterials and Biomaterials in Nanovaccinology
Authors:   Department of Clinical Research and EM Microscope, Pasteur Institute of Iran, Tehran, Iran, Hadidi Naghmeh , Sheikhpour Mojgan ,   Depetment of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran, Mohebbi Maryam ,   Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Sadat Seyed Mehdi ,   Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
Published: March 2024

Over the years, the concept of vaccination has encountered great evolution. Most vaccines have been formulated in a way that mimics pathogens in order to activate immune cascades. However, vaccine development was never assumed as a simple task and it involves several studies to obtain detailed knowledge about antigen presentation and recognition by immune system. Nanovaccination has been proposed as one of the most successful break throughs and procurements in health promotion and diseases prevention. Nano vaccines can be classified into various groups based on shape, source, sizes, features and structural constriction. Therefore they are assumed to offer more opportunities and novel approaches to scientists and researches and address unmet needs in vaccine developments. Novel technologies in vaccinology mostly focus on safety-immunogenicity improvements, synergistic immunomodulation, in vivo stability, reduced toxicity and efficient delivery of stimulatory cues. Biomaterials and nano vaccines were proved as promising strategies with optimal safety and efficacy through controlling the release site and pattern for better adjustment of dosing and timing of vaccines and immunotherapies. In this review, we have summarized future horizons and cutting-edge advances of biocompatible nano biomaterials-based platforms such as liposomes, nanoparticles, carbon based structures and membrane based vaccines. We also described the remaining challenges, limitations, and possible breakthroughs in nano vaccines’ formulation and biomaterials application in industrial scale.
Technical and Managerial Quality System for the Sustainability of the Oil Sector
Authors:   Chemical Engineering Sec, Design Department, Projects Division, MOC, Misan, Iraq, Al-Khazaali Wisam Mohammed Kareem , Ahmad Ataei Seyed ,   Chemical Engineering Sec, Design Department, Projects Division, MOC, Misan, Iraq, Al-Maryani Mohammed Hadi Radhi ,   Quality Management Department, Misan Oil Company, Misan, Iraq
Published: March 2024

The quality of administration and technical aspects in the oil sectors are essential to sustain its consumption in the future. The oil companies have developed its vision in getting ISO 9001:2015, ISO 45001:2018, ISO 14001:2015. These codes are essential in development in the continuity of administration procedures of quality system, occupational health, safety, and environment. It was found that the oil company need improve the performance through licensing other ISOs such as ISO 31000:2018, ISO 27001:2013, and ISO 50001:2018 for the risk assessment, information technology, and energy saving respectively. The technical product quality and green projects can be achieved by aiming and application of the modern international codes related to the product quality and environment.
Neonatal Bacteraemia and Antibiotic Resistance at the Angre University Hospital, Abidjan, 2020
Authors:   Bacteriology Unit, Medical Biology Department, Angre University Hospital, Côte d’Ivoire, IAD Yapi , YM Coulibaly-Diallo ,   Bacteriology Unit, Medical Biology Department, Angre University Hospital, Côte d’Ivoire, GAJ Bahan ,   Bacteriology Unit, Medical Biology Department, Angre University Hospital, Côte d’Ivoire, CG Tué Bi ,   Neonatalogy Unit, Paediatric and Specialties Department, Angre University Hospital, Côte d’Ivoire, IT Koné ,   Neonatalogy Unit, Paediatric and Specialties Department, Angre University Hospital, Côte d’Ivoire, A Kacou-N’Douba ,   Bacteriology Unit, Medical Biology Department, Angre University Hospital, Côte d’Ivoire
Published: March 2024

Background: Multi-drug resistant bacteria are an increasingly important cause of neonatal sepsis. Nowadays, they are a great concern in neonates because few therapeutic options are available. Aim: To determine the bacteria responsible of neonatal sepsis and their antibiotic susceptibility pattern in order to improve the quality of antibiotic prescription. Methods: A retrospective data review on positive blood cultures from the neonatal department at the university hospital of Angre between January to December 2020 was conducted. All neonates with clinical suspicion of sepsis with positive blood cultures were identified. Patient demographics, clinical details, and laboratory data were recorded and analyzed by Epi info software version 7.2.5.0 Results: Out of 221 blood cultures samples, 82 were positive (37%). The predominant age group was that between day 0 and day 7. A preponderance of bacteria of the genus Staphylococcus (48.78%) compared to enterobacteria (43.90%) was observed. The main isolated bacteria were coagulase-negative Staphylococcus (29.27%), Klebsiella pneumoniae (26.83%) and Staphylococcus aureus (19.51%). Streptococcus agalactiae was isolated in 2 cases (2.44%). Among the Enterobacteriaceae strains, 80.56% produced an Extended Spectrum Beta-Lactamase (ESBL). The rate of methicillin-resistant was observed in coagulase-negative Staphylococcus and Staphylococcus aureus in 37.50% and 31.25% of cases respectively. Out of ESBL strains, 89.65% were multi-resistant. Of the 14 strains of methicillin-resistant staphylococci, 13 (92.86%) were multidrug resistant. Conclusion: Coagulase-negative Staphylococcus and Klebsiella pneumoniae were the common causes of neonatal sepsis. The high rate of multi-drug resistant bacteria resistant represents a great threat to neonatal survival and warrants modification of existing empirical therapy.
Revisiting textbook azide-clock reactions: A “propeller-crawling” mechanism explains differences in rates
Authors: Bogetti Anthony , Zwier Matthew , Chong Lillian
Published: March 2024

An ongoing challenge to chemists is the analysis of pathways and kinetics for chemical reactions–including transient structures between the reactants and products that are difficult to resolve using laboratory experiments. Here, we enabled direct molecular dynamics simulations of a textbook series of chemical reactions on the hundreds of ns to µs timescale using the weighted ensemble (WE) path sampling strategy with hybrid quantum mechanical/molecular mechanical (QM/MM) models. We focused on azide-clock reactions involving addition of azide anion to each of three long-lived trityl cations in an acetonitrile-water solvent mixture. Azide additions are common click-chemistry reactions of great interest to synthetic chemists. Results reveal a two-step mechanism: (1) diffusional collision of reactants to form an ion-pair intermediate, (2) “activation”, or rearrangement of the intermediate to the product. Our simulations not only yield reaction rates that are within error of experiment, but also rates for individual steps, indicating the activation step as rate-limiting for all three cations. Further, the trend in reaction rates is due to differing extents of the azide anion “crawling” along the cation’s phenyl-ring “propellers” during the activation step. Our study demonstrates the power of analyzing pathways and kinetics to gain insights on reaction mechanisms, underscoring the value of including WE and other related path sampling strategies in the modern toolbox for chemists.
Aryl-substituted acridine donor derivatives modulate the transition dipole moment orientation and exciton harvesting properties of donor-acceptor thermally activated delayed fluorescence emitters, leading to highly efficient OLEDs
Authors: Crovini Ettore , Stravou Kleitos , Sahay Prakhar , Nguyen Binh Minh , Comerford Thomas , Warriner Stuart , Brütting Wolfgang , Monkman Andrew , Zysman-Colman Eli
Published: March 2024

Thermally activated delayed fluorescence (TADF) compounds are highly attractive as sensitising and emitting materials for organic light-emitting diodes (OLEDs) as they can harvest both singlet and triplet excitons and convert them into light. In this study we designed a series of derivatives of the widely studied donor-acceptor TADF emitter DMAC-TRZ with the objective of correlating their structure to their propensity to orient horizontally in vacuum-deposited doped thin films. This is important as the preferential horizontal orientation of the transition dipole moment (TDM) of the emitter, which tends to co-align with the long axis of D-A compounds, leads to enhanced light-outcoupling, and therefore higher maximum external quantum efficiencies (EQEmax) of the OLED. The decoration of the DMAC donor with substituted aryl groups also affects the emission color and the capacity for the emitters to efficiently harvest triplet excitons. The presence of electron-withdrawing 4-cyanophenyl and 4-trifluoromethylphenyl groups in, respectively, CNPh-DMAC-TRZ and CF3Ph-DMAC-TRZ blue-shifts the emission spectrum but slows down the reverse intersystem crossing rate constant (kRISC), while the opposite occurs in the presence of electron-donating groups in tBuPh-DMAC-TRZ and OMePh-DMAC-TRZ (red-shifted emission spectrum and faster kRISC). In contrast to our expectations, the OLED performance of the five DMAC-TRZ derivatives does not scale with their degree of horizontal emitter orientation but follows the kRISC rates. This, in turn, demonstrates that triplet harvesting (and not horizontal emitter orientation) is the dominant effect for device efficiency. Nonetheless, highly efficient OLEDs were fabricated with tBuPh-DMAC-TRZ and OMePh-DMAC-TRZ as emitters, with improved EQEmax (~ 28%) compared to the reference DMAC-TRZ devices.
LSM1-MS2: A Self-Supervised Foundation Model for Tandem Mass Spectrometry Applications, Encompassing Extensive Chemical Property Predictions and Spectral Matching
Authors: Asher Gabriel , Campbell Jennifer M. , Geremia Jack , Kassis Timothy
Published: March 2024

We introduce LSM1-MS2, a self-supervised foundation model pre-trained on extensive unlabeled MS2 data for tandem mass spectrometry. LSM1-MS2 leverages the complex data within MS2 spectra, bypassing the need for detailed identification and efficiently processing traditional MS2 data. The model's architecture, based on a specialized transformer and custom tokenization scheme, enables Masked Peak Modeling, which trains the model to reconstruct MS2 peaks, preparing it for various downstream applications. Fine-tuning LSM1-MS2 with a smaller, labeled dataset focuses on compound property prediction and identification through spectral matching, enhancing its practicality. Preliminary results demonstrate that the model predicts 209 RDKIT-extracted descriptors with a mean absolute error (MAE) of 3.35 on the CASMI 2022 dataset, outperforming recent supervised models. Notably, it requires only 1% of the labeled data used by traditional methods. LSM1-MS2's rich embeddings yield similar results to supervised models even without fine-tuning. In compound identification, LSM1-MS2 excels in database lookups, achieving a 0.07 MAE in Tanimoto similarity measurements on CASMI 2022, surpassing supervised models and traditional methods. It also retrieves close matches for known and unknown molecule queries more efficiently than conventional approaches. Overall, LSM1-MS2 demonstrates a transformative impact on mass spectrometry analysis, offering effective fine-tuning with minimal data and robust predictive abilities, reshaping traditional approaches in MS2 data utilization.