bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study
Authors: Zhang Wen-Jing , Yue Ke-Lin , Wang Jing-Zhai , Zhang Yu
Published: December 2023

BACKGROUND

We previously demonstrated that heat shock factor protein 4 (HSF4) facilitates colorectal cancer (CRC) progression. DNA methylation, a major modifier of gene expression and stability, is involved in CRC development and outcome.

AIM

To investigate the correlation between HSF4 methylation and CRC risk, and to uncover the underlying molecular mechanisms.

METHODS

Differences in β values of HSF4 methylation loci in multiple malignancies and their correlation with HSF4 mRNA expression were analyzed based on Shiny Methylation Analysis Resource Tool. HSF4 methylation-related genes were identified by LinkedOmics in CRC, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed. Protein-protein interaction network of HSF4 methylation-related genes was constructed by String database and MCODE algorithm.

RESULTS

A total of 19 CpG methylation loci were identified in HSF4 , and their β values were significantly increased in CRC tissues and exhibited a positive correlation with HSF4 mRNA expression. Unfortunately, the prognostic and diagnostic performance of these CpG loci in CRC patients was mediocre. In CRC, there were 1694 HSF4 methylation-related genes; 1468 of which displayed positive and 226 negative associations, and they were involved in regulating phenotypes such as immune, inflammatory, and metabolic reprogramming. EGFR , RELA , STAT3 , FCGR3A , POLR2K , and AXIN1 are hub genes among the HSF4 methylation-related genes.

CONCLUSION

HSF4 is highly methylated in CRC, but there is no significant correlation between it and the prognosis and diagnosis of CRC. HSF4 methylation may serve as one of the ways in which HSF4 mediates the CRC process.
Association of MBOAT7 rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis
Authors: Lai Min , Qin Ya-Lu , Jin Qiong-Yu , Chen Wen-Jing , Hu Jia
Published: December 2023

BACKGROUND

The MBOAT7 rs641738 single-nucleotide polymorphism (SNP) has been proven to influence various liver diseases, but its association with hepatocellular carcinoma (HCC) susceptibility has been debated. To address this discrepancy, we conducted the current systematic review and meta-analysis.

AIM

To perform a systematic review and meta-analysis on association of MBOAT7 SNP and HCC susceptibility.

METHODS

We performed a systematic review in PubMed, Web of Science, Scopus, and EMBASE; applied specific inclusion and exclusion criteria; and extracted the data. Meta-analysis was conducted with the meta package in R. Sensitivity and subgroup analyses were also performed. This meta-analysis was registered in PROSPERO (CRD42023458046).

RESULTS

Eight studies were included in the systematic review, and 12 cohorts from 6 studies were included in the meta-analysis. Our meta-analysis revealed an association between the MBOAT7 SNP and HCC susceptibility in both the dominant [odds ratio (OR): 1.14, 95% confidence interval (95%CI): 1.02-1.26, P = 0.020] and recessive (OR: 1.21, 95%CI: 1.05-1.39, P = 0.008) models. Subgroup analysis revealed that stratification of the included patients by geographical origin showed a significant association in Asia (OR: 1.20, 95%CI: 1.03-1.39).

CONCLUSION

This meta-analysis underscores the contribution of the MBOAT7 rs641738 SNP to hepatocarcinogenesis, especially in Asian populations, which warrants further investigation.
The Mobility Society
Authors:   NSC Global, Warburton Paul
Published: December 2023

Over the last century and a half, modern life has largely been characterized by stability and predictability, where individuals settled in one place and followed familiar routines. The late 19th century saw the rise of global brands and transportation advancements, making the world smaller in a virtual sense and more accessible in a logistical one. By the 1990s, global brands and easy transport were the norm, yet the patterns of life remained largely unchanged. About three decades ago, the pace of change quickened dramatically. Ties to a fixed location weakened, economic forces shifted, and telecommunications shifted from landlines to cellular and IP services. Norms around employment shifted, giving rise to the gig economy. Companies like Amazon and Uber reshaped expectations, leading to an "anything, anywhere, anytime" culture. The Mobility Society emerged, a constant evolution transcending place and time. This transformation is expertly explored and defined by the insightful mind of Paul Warburton, who has been at the forefront of this movement for over a decade. His "Now – Near – Far" structure has become a powerful tool in planning and understanding the changes that lie ahead. This book weaves together the complex web of technological and societal changes shaping the Mobility Society. For those involved in these transformations, this book offers fascinating insights, while for those in policymaking roles, it is a crucial guide to understanding and preparing for the inevitable evolution.
Implications of Off-road Automation for On-road Automated Driving Systems
Authors: Eley T.C. , King John Leslie , Lyytinen Kalle , Nickerson Jeffrey
Published: December 2023

Automated vehicles, in the form we see today, started off-road. Ideas,
technologies, and engineers came from agriculture, aerospace, and other off-road
domains. While there are cases when only on-road experience will provide the
necessary learning to advance automated driving systems, there is much relevant
activity in off-road domains that receives less attention.

Implications of Off-road Automation for On-road Automated Driving
Systems argues that one way to accelerate on-road ADS development is
to look at similar experiences off-road. There are plenty of people who see this
connection, but there is no formalized system for exchanging knowledge.

Click
here to access the full SAE EDGETM
Research Report portfolio.
Impact of Opt-Out Therapy Appointments on Resident Physicians’ Mental Health, Well-Being, Stigma, and Willingness to Engage
Authors: Kevern Taylor , Davies D. Rob , Stiel Katie , Raaum Sonja
Published: December 2023

Background Health care professionals report higher levels of mental health symptoms, pandemic-related stress, personal health concerns, and reduced proactive coping, especially in recent years marked by the COVID-19 pandemic. As physician utilization rates of mental health and well-being services remain low, the need for preemptive care is crucial.

Objective The present study sought to ascertain satisfaction, value, and attitude toward future mental health services among resident physicians.

Methods Throughout the 2020-2021 academic year, resident physicians within 8 training programs at a large academic training hospital were offered single opt-out mental health appointments from hospital-funded, graduate medical education wellness staff at no cost to the resident. Appointments were conducted virtually during protected work time. A survey was sent to participants within 2 weeks following their appointment.

Results A total of 153 residents (postgraduate years 1 to 7) were offered one-time opt-out appointments. Overall, 91 (59%) residents attended their opt-out appointments. Survey response rate was 57% (n=52). Respondents reported high levels of satisfaction (96%, 50 of 52), felt the appointment was worth their time (96%, 50 of 52), and felt that the opt-out appointments demonstrated training programs cared about their well-being (94%, 49 of 52). Nearly all residents (98%, 51 of 52) recommended appointments be offered to future residents. Most respondents (80%, 42 of 52) indicated that appointments increased their willingness to engage in mental health services.

Conclusions Opt-out appointments increased resident willingness to engage in mental health services, positive attitudes toward future mental health services, perceived training program’s care about their well-being, and reduced perceived mental illness stigma.
Implementation of a Quality Metrics Competition to Improve Panel Management Among Internal Medicine Residents
Authors: Deffendall Catherine , Lopez Christine , Trumbo Silas P. , Garrard Aelinor , Jones Jill , Peterson Neeraja B.
Published: December 2023

Background Panel management is essential for residents to learn, yet challenging to teach. To our knowledge, prior literature has not described curricula utilizing a financially incentivized competition to improve resident primary care metrics.

Objective We developed a panel management curriculum, including a financially incentivized quality competition, to improve resident performance on quality metrics.

Methods We developed a cancer screening and diabetes metric quality competition for internal medicine residents at Vanderbilt University Medical Center for their primary care clinics for the 2020-2021 (pilot) and 2021-2022 academic years. Residents received several educational tools, including a 1-hour introduction to the health maintenance dashboard within the electronic medical record (EMR) and instructions on how to access the quality dashboard outside the EMR, and were encouraged to discuss panel management with preceptors. Chief residents distributed measures to trainees 3 times annually, so residents were aware of their competition ranking. Residents’ composite metrics at year end were compared to baseline to determine top performers. The top 15 performers received $100 gift cards as incentives. We also assessed the curriculum’s impact on the residents’ metrics in aggregate.

Results At curriculum completion, residents (n=100) demonstrated an average improvement of 1.9% from baseline composite metrics for the percent of patients receiving screening. In aggregate, residents improved in every measure except HbA1c testing. Breast cancer screening had the largest improvement from 69.5% (1518 of 2183) to 75.6% (1646 of 2178) of all patients receiving recommended screening.

Conclusions The curriculum resulted in more patients receiving recommended cancer and diabetes screenings.
Giving Literal Thanks: An ACGME-Sponsored Initiative to Bring Residents Back to the Bedside
Authors: Diacovo Natalie , Gundewar Anisha , Wallace Alexandra , Scott-Vernaglia Shannon E. , Dzara Kristina , Healy Michael G. , Frey-Vogel Ariel S.
Published: December 2023

Background Resident burnout is at an all-time high. In response, the Accreditation Council for Graduate Medical Education (ACGME) developed the Back to Bedside grant for resident-led burnout interventions that increase the time residents spend with patients.

Objective We designed a resident-patient reading intervention, Giving Literal Thanks (GLT), intended to increase meaningful time residents spend with patients and thereby decrease burnout.

Methods All 65 pediatric residents rotating through our academic hospital’s inpatient units from Fall 2019 through Fall 2021 were invited to read and gift books to their patients. We studied our intervention’s relationship to resident burnout using a convergent mixed-methods design, including anonymous, unlinked pre-, peri-, and post-intervention surveys and focus groups. Qualitative and quantitative data were analyzed separately, then integrated to describe burnout pre- and post-intervention.

Results Forty-one of 65 residents (63.1%) completed pre-intervention surveys, and 8 of 65 (12.3%) completed post-intervention surveys. Twenty-seven resident-patient reading interactions were recorded, and 2 focus groups were held (1 pre- and 1 post-intervention). Five themes were identified: (1) limited opportunities exist to spend time at the bedside; (2) spending time at the bedside is valuable; (3) other responsibilities may preclude time at the bedside; (4) GLT could promote positive outcomes; and (5) GLT might not be the right tool to reduce burnout. Further quantitative data analysis was prevented by low survey response rates. While GLT was positively received and feasible, we were unable to show an improvement in burnout.

Conclusions GLT was well-regarded but may not improve resident burnout.
Multicenter Study of Optional In-Person Visits to Residency Programs After Virtual Interviews
Authors: O’Connor Alec B. , Blatt Amy E. , Fletcher Kathlyn E. , Martin Shannon K. , Rasnake Mark S. , Uthlaut Brian S. , Williams Donna M.
Published: December 2023

Background Compared to in-person recruitment, virtual interviewing reduces costs and promotes equity. However, many residency applicants believe that visiting programs helps inform their rank decisions.

Objective We assessed the feasibility of and stakeholder opinions about optional in-person visits after virtual interviewing and program rank list finalization.

Methods Six internal medicine residency programs conducted virtual recruitment in 2022-2023 and finalized their rank lists 4 weeks before the deadline. Applicants were invited for optional in-person visits after program rank list finalization. Interviewed applicants, program directors, and program administrators were given surveys that included 7-17 questions and employed “skip logic,” discrete answers (eg, “yes/no/unsure” or multiple choice), and open-ended questions. Survey questions assessed stakeholders’ opinions about the value, equity, and potential downsides of this recruitment process.

Results Participating programs interviewed an average of 379 applicants (range 205-534) with 39 (10.3% [39 of 379], range 7.9%-12.8% [33 of 420-51 of 397]) applicants completing in-person visits. Of 1808 interviewed applicants, 464 responded to the survey (26%); 88% (407 of 464) believe a similar optional in-person visit should be offered next year, 75% (347 of 464) found this process equitable, but only 56% (258 of 464) trusted programs not to change their rank lists. Nearly all who attended an in-person visit (96.5%, 109 of 113) found it valuable. All program directors liked the optional in-person visit and believe future applicants should be offered similar in-person visits.

Conclusions A large majority of participating applicants and program directors believe that in-person visits should be offered after program rank list finalization. The majority of respondents felt this recruitment process was equitable.
Annonacin and Squamocin Conjugation with Nanodiamond Alters Metastatic Marker Expression in Breast Cancer Cell Line
Authors: Dewi Firli Rahmah Primula , Sri Puji Astuti Wahyuningsih  , Adelah Putri Milenia Sari  , Umi Nur Alfiah  , Vuanghao Lim  , Ummi Zubaidah  , Alfiah Hayati
Published: December 2023

Breast cancer can perform metastasis to distant organs and cause more than 90% of malignancy-related deaths. The anti-metastasis potency of nanodiamond-conjugated annonacin and squamocin against MCF-7 cells is currently studied. First, IC50 determination of both free annonacin and squamocin to evaluate their potency as cytotoxic agents. Upon getting the IC50 value, both compounds are conjugated into nanodiamonds. Drug loading efficiencies of nanodiamond-conjugated annonacin and squamocin are 88.9% and 89.1%, respectively. Meanwhile, the ND-annonacin and ND-squamocin complex size is 150-300 nm based on SEM imaging. Subsequently, cell viability assessment of MCF-7 was performed with six cohort designs, namely, K (control cell), AN (annonacin), SQ (squamocin), NDAN (nanodiamond-conjugated annonacin), and NDSQ (nanodiamond-conjugated squamocin). Both IC50 and cell viability are assessed by MTT assay after 24 h incubation. All cohorts also underwent gene expression analysis subject to the metastasis markers CTNND1 (catenin delta 1), NOTCH4, and C-JUN. Here, the IC50 of both free annonacin (4.52 µg/ml) and squamocin (10.03 µg/ml) are more than IC50 of potent anticancer (< 4 µg/ml) for pure compounds. However, nanodiamond conjugation to both compounds can decrease cell viability better than free compounds. Compared to K, nanodiamond-conjugated annonacin and squamocin significantly decreases cell viability after 24 h incubation. Bioinformatics analysis confirmed significant pro-metastasis (C-JUN and NOTCH4) upregulation and anti-metastasis (CTNND1) downregulation in tumors compared to normal. Recent findings demonstrated that nanodiamond-conjugated annonacin can significantly upregulate CTNND1 and significantly downregulate C-JUN and NOTCH4. Even so, nanodiamond-conjugated squamocin upregulate CTNND1 but not significantly and significantly downregulate C-JUN and NOTCH4.
Bioethanol Production from Non-Conventional Yeasts Wickerhamomyces anomalus (Pichia anomala) and Detection of ADH1 Gene
Authors: Fathiah Muhammad Fadhil , Hartono Faisal Diniamal , Astuti Rika Indri , Listiyowati Sri , Meryandini Anja
Published: December 2023

Bioethanol is an organic compound resulted from the fermentation of sugar substrates by microorganisms which is used as alternative energy sources.  During bioethanol fermentation yeast are exposed to various fermentation stresses, including temperature, osmotic, and oxidative stresess. Such conditions may decrease ethanol production. We previously isolated fermentation-stress tolerance yeast isolates from traditional Balinese beverages, identified as Wickerhamomyces anomalus BT2, BT5, and BT6. However no data available regarding the bioethanol production of those isolates. Our study indicates that these strains could utilize various sugar substrates (glucose, xylose, maltose, sucrose) in oxidative fermentative media. The highest value of substrate utilization efficiency following 48 hours fermentation was shown by BT6 on glucose (61.02%), BT 2 on xylose (55.44%) and maltose (60.90%). Measurement of ethanol production by Gas Chromatography showed that the strains were able to produce higher ethanol on the glucose substrate than other substrates. For instance, BT6 could produce the highest ethanol production (5.00 g/L) amongst strains tested by using glucose as substrate. Yet, the particular strains could only produce 0.30 g/L and 0.65 g/L by using xylose and maltose, respectively. For further genetic engineering purposes, we detected ADH1 gene from all three isolates, with high homology to the alcohol dehydrogenase from Saccharomyces cerevisiae, Geobacillus stearothermophilus and Pseudomonas aeruginosa. Further strain development can be carried out targeting the ADH1 gene, important for ethanol fermentation.
Phytochemical, Antioxidant and Antimicrobial Activities of Hevea brasiliensis Leaves Extract
Authors: Kusumarn Noipha  , Piyanuch Suwannarat  , Supattra Prom-in  , Titpawan Nakpheng
Published: December 2023

Belonging to the Euphorbiaceae family, the Para rubber tree is formally referred to as Hevea brasiliensis in scientific terms. It is commonly known as an important economic commodity in Thailand because the natural rubber primarily originates from the milky latex obtained from the tree. However, the available research on the phytochemicals found in different parts of the rubber tree and their biological effects is quite restricted. This study aimed to determine the phytochemical constituents, antioxidant and antibacterial activity studies on the crude dry leaf extracts of H. brasiliensis. The results indicated the presence of alkaloids, anthraquinones, cardiac glycosides, coumarin, flavonoids, saponin, steroids, tannins, and terpenoids. The total phenolic content was 63.95±4.31 mgGAE/g in the ethanolic leaf extract. The ethanolic extract displayed notable effectiveness in scavenging free radicals (71.2±0.17%) at 500 μg/ml concentration and antioxidant capacity (the lowest IC50 value 42.57±0.91 μg/ml). The ethanol extract of the leaf of H. brasiliensis showed  inhibition zone on all of the selected bacteria (gram-positive; Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, and gram-negative; Escherichia coli, Pseudomonas aeruginosa) at 200 mg/ml. In conclusion, the dried leaves of H. brasiliensis compose phytochemicals that exhibit antioxidant and antibacterial activities and possesses the potential to act as a reservoir of plant-derived antibiotics and natural antioxidants.
Topical Application of Paraboea leuserensis on Excision Wound with Angiogenesis and Vascular Endothelial Growth Factor Analysis
Authors: Heryani Dyah Wijiana , Maya Wardhani Fiska , Yensuari  , Nazimuddin Putri Nadya , Nardi Leo , Ikhtiari Refi
Published: December 2023

Gagatan harimau or Paraboea leuserensis B.L. Burtt is an endemic plant that grows in limestone areas, natively found in Leuser Mountain Area, North Sumatra Province, Indonesia. This study determines the wound healing potential of P. leuserensis gel-based ethanolic extract (PGEE) on full-thickness excision wounds based on the angiogenesis and VEGF expression. Here, we reported 67 compounds detected by LC-MS/MS from the ethanolic extract. The antibacterial activity regarding pathogenic wound infection was also investigated. The experimental study used 30 Rattus novergicus, randomly divided into five treatment groups: base gel as a negative control, Bioplacenton as a positive control, PGEE 2.5%, 5%, and 10%. Experimental data showed that PGEE indicated a significant effect on bacterial inhibition (p = 0.02), where the greatest inhibitory was found against S. epidermidis. Topical application of PGEE showed significant differences in the number of blood vessels of PGEE 2.5% and 10% (p = 0.007) and expression of VEGF (p<0.05). The correlation between the number of blood vessels and VEGF was also described with the number of macrophages, fibroblasts, collagen, and wound diameter. Overall, this study demonstrates the pharmacological potential of PGEE for wound healing applications regarding angiogenesis and VEGF expression.
DNA Barcoding of Six Commercially Important Groupers (Epinephelidae) from Langsa, Aceh, Indonesia
Authors: Fadli Nur , Jumiati Sri , Razi Nanda Muhammad , Damora Adrian , Muchlisin Zainal A. , Dewiyanti Irma , Ramadhaniaty Mutia , Harnelly Essy , Habib Ahasan , Siti-Azizah Mohd Nor
Published: December 2023

Groupers are among the fish groups that are difficult to recognize due to their high morphological similarities. Therefore, molecular techniques, particularly DNA barcoding, are extensively utilized to differentiate this fish group. This study aimed to analyze and validate six grouper species belonging to the Epinephelidae family that were harvested from Langsa district waters in Aceh province, Indonesia, based on DNA barcode data. It was conducted from June to December 2021, with the fish specimens collected from fishers at fish landing sites and the fish market in Langsa City, Aceh province. A total of 22 grouper sequences belonging to six species were generated, namely Epinephelus coioides, E. bleekeri, E. malabaricus, E. erythrurus, E. sexfasciatus and Mycteroperca poecilonotus (formerly Epinephelus poecilonotus). Genetic distance within these species ranged from 0.10 to 0.73% (average: 0.40%). Notably, E. malabaricus and E. coioides exhibited the closest genetic kinship (4.07%), while E. sexfasciatus and M. poecilonotus displayed the greatest genetic distance (19.33%). This study provides the first DNA reference for grouper in Langsa district, Indonesia, with significant implications for future sustainable grouper management.
Cloning and Production of Antigen 85A Mycobacterium tuberculosis for Diagnostic Latent Tuberculosis: a Preliminary Study
Authors: Agus Rosana , Sjafaraenan  , Samara Yulianti , Massi Muhammad Nasrum
Published: December 2023

The main challenge in the management of Tuberculosis (TB) is diagnosing quickly and accurately, especially Latent Tuberculosis Infection (LTBI). LTBI detection was carried out using the Tuberculin Skin Test (TST) and Interferon Gamma Release Assay (IGRA). In TB endemic areas, these two examinations have limitations, so current research is directed at finding specific antigens for the diagnosis of LTBI. One  of the potential proteins is Antigen 85A (Ag85A) Mycobacterium tuberculosis (Mtb) encoded by Fibronectin-binding protein A (FbpA). The Ag85 complex induces the proliferation of T-cells and interferon-gamma in most healthy individuals infected with Mycobacterium tuberculosis, Mycobacterium leprae, and BCG-vaccinated mice, making it a potential antigen. This study aims to clone and produce recombinant protein Ag85A from Mtb in Escherichia coli BL21. The methods used were ligation to the pET-32a expression vector, transformation to Escherichia coli BL21, and production of protein by IPTG induction. Characterization of recombinant clones by colony PCR and sequencing. The results obtained were that the fbpA gene isolated from Mtb clinical isolate had been amplified, and the PCR product was 900 bp. The production of Antigen 85A has been successfully carried out and produces 44 kDa.
Isolation and Characterization of Chalcone Synthase (CHS) Gene in Variegated-Flower of Dendrobium 'Enobi' and Phalaenopsis Hybrid Orchids
Authors: Linggabuwana Aviesta , Putri Saifa Usni , Kurniawan Febri Yuda , Semiarti Endang
Published: December 2023

Variegated flowers, characterized by the presence of different colors in flowers, have high economic and aesthetic values. The main pigment in the orchid's purple flowers is anthocyanin, while the chalcone synthase (CHS) gene is the key to anthocyanin biosynthesis. Analysis of the CHS gene can reveal some changes, including mutations, in the process of color patterning in flowers. This study aims to determine the structure of the CHS gene related to color patterning in Dendrobium 'Enobi' and Phalaenopsis hybrid with variegated flowers. The methods applied in this study are floral morphology observation, DNA isolation, CHS gene amplification, anthocyanin measurement, and bioinformatic analysis. Morphologically, the variegated pattern has appeared since the flowers were still in the bud on both orchids. Based on the anthocyanin content analysis, the difference in the genus is not directly related to the differences in the flower's anthocyanin content. In addition, the purple zone in the D. 'Enobi' and Phalaenopsis hybrid has a longer fragment of CHS than the white zone. Our analysis suggested several mutations in the white zone and differences in the type and location of several conserved domain proteins. Mutations at the CHS gene fragment might cause decreased anthocyanin pigment formation in the white region.
Production of Polyurethane Elastomers from Ximenia americana L (Wild Olive) Seed Oil and Diisocyanates
Authors: Samuel A. E. , Eremosele I. C. , Kamba S. Y. , Samaila D. S.
Published: December 2023

Seed oils readily undergo derivatization by alcoholysis to yield biodegradable polyols and Ximenia americana plant from the family of Olacaeae has oily seeds. Hence, the objective of this paper is to assess the production of polyurethane elastomers from Ximenia americana L (Wild Olive) Seed Oil with diisocyanates, namely, hexamethylene diisocyanate (HDI), toluene diisocyanate (TDI) and 4,4’-methylene diphenyl diisocyanate (MDI) respectively using standard procedure and characterized by Fourier-Transform Infrared Spectroscopy (FTIR), Instron Tensile Testing Machine and Thermogravimetric Analyzer (TGA). The tensile strength and tensile modulus for HDI-based polyurethane elastomers, 5.83±0.15 and 3.95±0.07 MPa respectively are higher than the corresponding ones for TDI- and MDI-based polymers. This is consistent with the highest crosslink density (γ) of 5.05×10-3 for HDI-based polymer with corresponding average molecular weight between crosslinks (Mc) of 197.87 gmol-1  The polyurethane elastomers are stable up to 250-265oC with order of stability: HDPU-1.50>MDPU-1.50>TDPU-1.50. The results showed that diol from Ximenia americana seed oil is effective for production of polyurethane elastomers with properties which are comparable to ones of the non-oil-based polymers.
Cumhuriyet Dönemi’nde İzmir’de Yaşanan 6 Büyüklüğü ve Üzeri Depremler
Authors: ASLANER Muhammed , ÇOLAK Filiz
Published: December 2023

Yerkabuğu ve yer hareketleri bakımından dünyanın en hareketli deprem alanlarından birinde bulunan Türkiye, geçmişten günümüze barındırdığı aktif faylar ile birçok yıkıcı depremin yaşandığı bir coğrafya olmuştur. Anadolu, dünyadaki deprem kuşakları içinde Alp-Himalaya Deprem Kuşağı üzerinde yer aldığından hem geçmişte hem de günümüzde can ve mal kaybına neden olan depremlere sahne olmuştur. Türkiye’de üç tane ana deprem kuşağı mevcuttur. Kuzey-Anadolu Fay Zonu, Batı-Anadolu Genişleme Bölgesi, Doğu-Anadolu Fay Zonu. Çalışmaya konu olan İzmir ili de Batı Anadolu Deprem Kuşağı içinde yer almakta olup geçmişten günümüze pek çok depremin yaşandığı bir yerdir. Bu çalışmada Cumhuriyet döneminde İzmir’de gerçekleşen 6 büyüklüğü ve üzeri depremler ele alınmaktadır.
Examination of the Interaction Process between Architecture Students and Supervisors in the Thesis Studio
Authors:   Department of Architecture and Design, School of Architecture and Built Environment,  College of Science and Technology, the University of Rwanda, Rwanda, Tafahomi Rahman
Published: December 2023

This paper aims to criticize the current supervision process in the undergraduate thesis project in the architecture program to reveal philosophical contradiction exists in the schools of thought. The architecture programs have adopted an apprenticeship style of education as a tradition that is called learning by doing even in the thesis projects. However, new schools of education and thought are looking for more students’ freedom and flexibility. A qualitative method with focus group workshops and group reporting techniques was applied in the research to discover the opinions of the thesis students about the supervisors and their own works and progress. Data was extracted from the reports of the students. The findings reveal that the students received guidance for the design process and outputs. However, they faced problems in keeping ownership of the thesis project idea, communication, interaction, and motivation with the supervisors. The power of the supervisors over the students resulted in changing the projects, crits, and outputs in the absence of clear guidelines in more personal manners. In conclusion, thesis projects include complicated processes that need clear guidelines and training for supervisors, even undergraduate theses in architecture departments. Despite the apprenticeship tradition in architecture education, new findings in education recommended a knowledge-based orientation for the supervision process.
SAVREMENA NEMAČKA KVIR KNjIŽEVNOST U INTERNACIONALNOJ GERMANISTICI (SA PRIMEROM IZ NASTAVNE PRAKSE)
Authors:   University of Kragujevac, Faculty of Philology and Arts, Petrović Jilih Marina M.
Published: December 2023

Building on the current literary and didactic discourse of the German-speaking area, which only started to deal with the issue of queer literature in 2017, the subject of this paper is the analysis and categorization of the material created on the basis of students’ texts written after reading the queer novel „Lass uns von hier verschwinden” by Julian Mars and „Blood- book” by Kim de l’Horizon. Using qualitative research methods, an answer to the following research questions is expected: How to train female and male students to deal with LGBTI+ literature with pleasure, and whether dealing with such literary texts lead to consolidation or change in terms of values and to social engagement. The main goal of the teaching is the train- ing for participation in the cultural discourse. Queer issues have gained special importance in the last few years (and not only) in our country. This is proven by the events before and during EuroPride in Belgrade in September 2022. This study has been conducted with 16 students at the Department of German Language and Literature at the Faculty of Philology and Arts at the University of Kragujevac. During the implementation of teaching and research from October 2022 to January 2023, they were fourth-year students. Although representative, this research can generate fruitful impulses (for now only) for university teaching of literature at all philological departments in the country and region.
READING DOYLE’S „THE HOUND OF THE BASKERVILLES“ THROUGH THE PRISM OF THE GOTHIC GENRE
Authors:   University of Belgrade, Faculty of Philology, Ivanović Dušan B.
Published: December 2023

The exploitation of Gothic elements in detective fiction was long regarded as a skillful way to create an atmosphere of suspense and mystery. However, writers have often relied on the power of the Gothic not only to intrigue and unsettle the reader, but also, more importantly, to direct attention to complex taboo topics of their time. This essen- tial function of the Gothic can be identified in Arthur Conan Doyle’s detective novel The Hound of the Baskervilles, which alludes to many delicate issues of the fin-de-siècle British society, including violence, mental illness, and criminality. These phenomena were often exam- ined by late Victorians in the light of degeneration theory, which held that abnormal forms of behavior were signs of bad heredity and bio- logical regression. Thus, this paper investigates whether degeneration theory played a role in Doyle’s characterization of the novel’s criminal antagonist Jack Stapleton by focusing on how his appearance, behavior, and actions are represented in the text. It is argued that Doyle delib- erately uses the Gothic motif of duality to disperse the illusion of a clear boundary between the civilized “self” and the barbaric “other,” thereby implicitly stressing the complexity of human nature. Accordingly, the analysis, which rests on Freud’s psychoanalytic theory, reveals that Stapleton’s moral decay should not be read as an indicator of his hereditary predisposition toward crime but rather as a result of mental tensions that he fails to control.
L. N. TOLSTOJ I F. M. DOSTOJEVSKI KAO PRETEČE RUSKE RELIGIJSKE FILOZOFIJE
Authors:   University of Novi Sad, Faculty of Philosophy, Milentijević Lazar P.
Published: December 2023

This paper examines the main theses of L. N. Tolstoy and F. M. Dostoevsky, expressed in works, drafts and letters, and became the cornerstone in the formation of Russian religious philosophy of the 19th and 20th centuries. Despite the fact that in the works of Lev Tolstoy and F. M. Dostoevsky it is impossible to find a dissected and detailed philosophical or theological system, their contribution to the development of Russian religious philosophy cannot be over- estimated, as evidenced by the works of S. N. Bulgakov, D. S. Merezhkovsky, P. A. Florensky, V. V. Rozanov, Vyach. Ivanova, L. I. Shestov, A. L. Volynsky, S. A. Askoldov, V. V. Zenkovsky, N. O. Lossky, etc. The comprehension of two great writers of the 19th century is a reaction of the turn-of-the- century era to cultural, social and historical circumstances that led to new needs and ques- tions, and also forced a reassessment of the value system. In this context, the article shows that the concept of „goodness”, to which Leo Tolstoy repeatedly returned, has again become relevant among Russian religious philosophers. Religious philosophy itself in the image of Tolstoy found its almost tactile confirmation, if we take into account the clearly protruding bonds between the writer’s life and his work. On the other hand, Dostoevsky’s work found a greater response due to his commitment to a more orthodox understanding of Christianity with a clearly expressed neo-mythologization. The study examines the most important artistic principle of Dostoevsky called „realism in the highest sense”, which played an important role in the development of symbolist poetics.
PSIHOLOŠKE STUDIJE LIČNOSTI UMETNIKA
Authors:   Visoka škola socijalnog rada, Beograd, Srbija, Pejić Biljana S.
Published: December 2023

The paper analyzes different theoretical and empirical approaches to the personality of the artist. It presents a synthesis of various relevant ideas and their perception from a more gen- eral level, to assemble these ideas into a broader picture concerning the issue of the artist’s per- sonality. The analysis shows that all psychological theories were focused on individual aspects of the personality of the artist. Psychoanalytic approaches are based on the idea of discovering personal neurotic roots hidden in the subconsciousness of the creator. Gestalt psychology sees creation as based on talent, and gift and the artist is observed as a person with specially devel- oped capabilities for perception and visual thinking. Humanistic psychology sees creativity as a universal human potential and trait theories are looking for the unique composition of personality traits in the artist. However, each one is individually important, because it con- tributed to the understanding of artistic creation and the personality of the artist as a whole. Throughout history, the artists were observed as great creators, or as madmen. Varieties and differences between the concepts could be understood by the fact that each artist is great and unique in his/her originality.
Timber Traceability: A Diagnostic Tool for Practitioners and Policymakers
Authors: Stäuble Tobias , Nogueron Ruth , Knorr-Evans Maite , Schneider Martina
Published: December 2023

Traceability is recognized as important for the legitimacy and credibility of natural resource management, and as a tool to support and demonstrate compliance with legality and sustainability requirements. This report seeks to provide practical technical guidance to decision-makers and designers of government-sponsored timber traceability systems so that they can better define their needs and design and implement traceability systems that respond to the specific needs and context of the country.
Effectiveness Of Employee Engagement On Hotel Staff Performance
Authors: Sheta Nadia Nara , Catur Afriasih Maria Ulfah
Published: December 2023

Employee engagement is the attachment of employees to the company. Employees who are tied to actively engaged companies tend to have higher levels of productivity. There are many elements that affect employee performance, including the interaction between the workforce and the workplace environment. The objective of this study is to ascertain how employee involvement affects hotel staff's performance. The population of this study was made up of employees of the hotel, with 65 respondents. Data collection techniques using Google Form Questionnaires This research method is a descriptive analysis with a quantitative approach. The methods used are the validity test, reality test, descriptive statistical analysis, mean test, and Spearman rank correlation test. The findings indicated that the correlation of 0.969 shows a very strong relationship between the variables of employee engagement and performance. It can therefore be concluded that raising employee engagement will also raise employee performance. There is a very strong and unidirectionally significant association between staff engagement and performance at Hotel Jakarta if it can be determined that H0 is rejected and H1 is approved.
Identification Of Ecotherapy Design Criteria In Public Open Spaces As An Effort To Improve Visitor’s Mental Health
Authors: Prasandya Km. Deddy Endra , Satria Made Wina , Adiartha Made Arya
Published: December 2023

All activities that occur in public open spaces are basically forms of human expression as social beings who always have a deep relationship with the environment in meeting physical, psychological and social needs. Referring to mental health, the role of public open space is very important nowadays considering the number of teenagers with mental disorders in Indonesia, especially in Bali is very high. The role of public open spaces in improving the mental health of visitors is needed to reduce the prevalence of depression. The concept of ecotherapy in public open spaces can be implemented to promote mental health through human interaction with green spaces. This study aims to formulate ecotherapy design criteria in public open spaces and find out the design elements of public open spaces in Denpasar City and Klungkung Regency that need to be adjusted to be able to implement the ecotherapy concept. A synthesis of various ecotherapy theories and the link between public open spaces and mental health, as well as various studies or studies that have been conducted previously were carried out to formulate ecotherapy design indicators and sub-indicators in public open spaces. The research method used is mixed methods, by applying qualitative and quantitative approaches. The results of the study concluded that the two public open spaces which are the objects of study need to adjust the accessibility criteria, location, zoning, parking, furniture, facilities, and sign systems.
Analysis Of Domestic Tourist Satisfaction And Loyalty In Penglipuran Tourism Village, Bangli
Authors: Artha Putra I Nengah Sandi , Arini Ni Nyoman , Raditya I Putu Tiana
Published: December 2023

Penglipuran Tourism Village is an independent tourist village that has been developing since 1993. In its development, tourist behavior is very important to know. Two important aspects that must be known are tourist satisfaction and loyalty. In tourism marketing studies, there are many aspects that influence satisfaction and loyalty, including tourist motivation and destination attributes. Analyzing tourist behavior is very important as an evaluation step and a sustainable marketing strategy. The aims of this research are 1) to analyze the influence of motivation and destination attributes on tourist satisfaction, 2) to analyze the influence of motivation and destination attributes on tourist loyalty, 3) to analyze the influence of tourist satisfaction on tourist loyalty. This research was designed using quantitative methods which aim to analyze the size of the correlation and causal relationship between variables and justify the significance of each hypothesis. One hundred domestic tourists who have visited are the samples in this study. The sample was determined using accidental sampling by distributing questionnaires online via Google Form. Data were analyzed using SEM (Structural Equation Modeling) with SmartPLS software version 3.0. The research results show that 1) motivation does not have a significant effect on tourist satisfaction. Destination attributes have a significant effect on tourist satisfaction, 2) motivation does not have a significant effect on tourist loyalty. Destination attributes do not have a significant effect on tourist loyalty, 3) tourist satisfaction has a significant effect on tourist loyalty. Through the findings of this research, it can be used as reference material for sustainable marketing in looking at the behavior of domestic tourists who visit the Penglipuran Tourism Village.
Readliness Level Of Mobile-Based Mini English-Indonesia-Korean Dictionary Application Implementation In Improving The Tourism Sector
Authors: Kusuma Dewi Ayu Aprilyana , Indrawan I Putu Eka
Published: December 2023

The tourism sector has the advantage that it is currently undergoing continuous expansion and diversification compared to the manufacturing sector. Current tourism development in various regions offers innovative services through the application of information and communication technology. Currently, the application of mini dictionary applications is more widely applied in city tourism areas that have complete basic infrastructure, adequate availability of information and communication technology and a comprehensive service system. In the tourism sector in Indonesia has considerable potential and attractiveness in the natural and cultural tourism sector, in the development of tourism the central government through The Ministry of Tourism and Creative Economy/Tourism and Creative Economy Agency in each province has the aim of increasing the number of visits and services. This research will examine each tourist attraction, which in its development has developed as an urban area with the availability of supporting tourism facilities / infrastructure that has been fulfilled. The purpose of this study is to identify the level of readiness of tourist attractions in implementing mini dictionary applications in terms of the availability and quality of basic infrastructure services and ICT and tourist support facilities. This research uses the waterfall process method used to describe the research approach to the analysis process. The results of the analysis show that the level of readiness of the application of mini dictionaries at tourist attractions is stated to be against ready. The readiness of the application of the mini dictionary in terms of the availability and quality of basic infrastructure services and ICT and tourist support, based on the results of a review of all components in its application that can be reviewed from infrastructure, facilities and service systems shows that almost all tourist attractions have shown readiness in basic infrastructure and for ICT infrastructure and tourist support facilities are still in a somewhat ready position. This is due to the inadequate quantity and also ICT that has not been applied in tourism management.
Improving Photovoltaic Grid Integration under Partial Shading by Equilibrium Slime Mould Optimization
Authors:   Laboratory of Identification, Command, Control and Communication (LI3CUB), University of Biskra, Algeria, ZABIA Djallal Eddine , AFGHOUL Hamza ,   LEPCI Laboratory, Faculty of technology, Ferhat Abbas Setif-1 University, Algeria, KRAA Okba ,   Laboratory of Energy System modeling electrical engineering (LMSE), Algeria, KRIM Fateh ,   LEPCI Laboratory, Faculty of technology, Ferhat Abbas Setif-1 University, Algeria
Published: December 2023

In the realm of photovoltaic grid integration with Shunt Active Power Filters operating under partial shading conditions, this study introduces an innovative approach aimed at minimizing both power consumption from the electrical grid and associated costs. The primary objective of this research is to maximize the efficiency of photovoltaic system output by implementing a novel algorithm known as the Equilibrium Slime Mould Optimization technique. This algorithm is employed to precisely track the global power point of the photovoltaic array under partial shading conditions, resulting in increased photovoltaic power injection and decreased grid-side consumption. The choice of the Equilibrium Slime Mould Optimization technique is motivated by its exceptional ability to efficiently explore the search space and avoid falling into local extrema. Additionally, this article incorporates Predictive Direct Power Control, one of the most contemporary Shunt Active Power Filter control techniques, to effectively eliminate harmonics and enhance overall system efficiency. To validate this proposed approach, a simulation setup was meticulously developed. The obtained results demonstrate a remarkable enhancement in the efficiency of photovoltaic power injection compared to the conventional sliding mode technique, which tends to get trapped at local maximum power point, thereby resulting in diminished power injection. This pioneering approach heralds a new era in the application of metaheuristic algorithms within practical systems, leading to enhanced productivity and reduced costs for consumers. Furthermore, it holds the potential to advance various categories of interconnected photovoltaic systems, ensuring improved performance across diverse operational scenarios.