bluuebunny/crossref_metadata_2025 huggingface dataset:
Kapitał społeczny młodych mieszkańców miasta na przykładzie wybranych wskaźników
Authors:   Uniwersytet Rzeszowski, Bździuch Sławomir
Published: September 2024

The main purpose of this article is to present the results of a survey of two selected social capital indicators conducted by the author among young city residents. The indicators, which have been within the research process, are “trust” and “voter turnout”. For the purposes of the article, the author assumed that young residents of the city are students of universities located in the city of Rzeszow. The results obtained as part of the research were compared for comparison purposes with surveys conducted by the Public Opinion Research Center (CBOS) and voter turnout, which was published by the National Electoral Commission (PKW).
Wizerunek miasta w świadomości młodych użytkowników przestrzeni Rzeszowa
Authors:   Uniwersytet Rzeszowski, Palak Mariusz
Published: September 2024

In the era of increased competition between cities, building a positive image of the city is becoming an important element of marketing strategies. The image of a city includes all subjective ideas of reality that are formed in people’s minds as a result of perception, the influence of mass media and informal information messages. The image of a city includes both physical and emotional elements. Physical elements are objective characteristics of a place, such as its size, location, spatial structure, condition of infrastructure and type of development. Emotional elements include people’s emotional attitude and sympathy towards a given place. Therefore, all promotional activities undertaken by the authorities and changes in the city space may affect these image elements. Some changes may have a positive impact while others may have a negative impact on one’s image. The aim of the article is to present the results of a study on the image of Rzeszów. The study was conducted in spring 2022 on a sample of 415 students of the University of Rzeszów. The CAWI technique was used to collect data. These are not the first analyzes of the city image phenomenon. Previous publications show that the subjective image of the city in the minds of its inhabitants is positive. Residents point out to many good changes that have taken place in urban space in recent years. The most important ones included increasing the city’s aesthetics, improving the quality of streets and expanding the city to include surrounding towns. Unlike previous studies, which were mainly devoted to measuring hard and soft quality of life indicators, this time the focus was on assessing the specificity and originality of Rzeszów in the minds of the respondents.
O OLHAR DOS DOCENTES SOBRE OS DESAFIOS DO ENSINO REMOTO EM NUTRIÇÃO E SAÚDE COLETIVA
Authors: Melo de Carvalho Giovanna , Wiering Pinto Telles Mauricio
Published: September 2024

Este estudo investiga os desafios e repercussões do Ensino Remoto Emergencial (ERE) na formação de estudantes de Nutrição em uma universidade pública do Rio Grande do Norte, focando especialmente no ensino de Saúde Coletiva, sob a ótica dos docentes da área. O ERE foi implementado devido à pandemia de COVID-19, afetando diretamente a qualidade do ensino, especialmente em cursos da área da saúde que exigem práticas presenciais. A pesquisa utilizou abordagem qualitativa, por meio de entrevistas semiestruturadas com docentes que ministram disciplinas relacionadas à Saúde Coletiva. Os resultados indicam que, apesar do esforço dos professores em adaptar suas metodologias ao ambiente virtual, houve desafios significativos, como a baixa participação dos alunos e dificuldades técnicas. Além disso, a falta de interação presencial prejudicou a formação prática e o desenvolvimento de competências essenciais para a atuação profissional no Sistema Único de Saúde (SUS). As conclusões ressaltam a importância do aprendizado presencial dentro da Saúde Coletiva e a necessidade de se repensar o papel das Tecnologias da Informação e Comunicação (TICs) na educação em saúde.
LOW POWER AND AREA EFFICIENT CNTFET BASED DECODER FOR SRAM DESIGN WITH 1K CELLS
Authors: Valluri Aswini , Musala Sarada , Lakshmi Posani Vijaya
Published: September 2024

Low power and fast access static random access memory (SRAM) with reduced transistor count is essential in the integrated circuits due to an exponential increase in the demand of portable battery operated devices such as biomedical implants. SRAMs occupy major portions of the die area. The peripheral devices include a write driver, a wordline driver, sense amplifier, precharge circuit, and decoders. The decoder is an important block since it takes about half of the chip's access time and significant part of
the total power during the read or write cycle. This article presents a low power SRAM design of 1 k cells with a 5 to 32 size decoder using the proposed 5 transistor AND gate. The design is implemented in cadence using CNTFET 32 nm technology operated at 900 mv.
Bould, Mark. The Anthropocene Unconscious: Climate, Catastrophe, Culture. Verso, 2021.

Authors: Schmeink Lars
Published: September 2024

Review of The Anthropocene Unconscious by Mark Bould.
Is there an association between glomerular hyperfiltration and coronary flow velocity reserve in patients with gestational diabetes history?
Authors: Takir Mumtaz , Telci Caklili Ozge , Betul Ozcan Fatma , Atici Adem , Caliskan Mustafa
Published: September 2024

Glomerular hyperfiltration (GHF) is an early marker of chronic kidney disease (CKD) and may predict coronary microvascular dysfunction, presenting as reduced coronary flow velocity reserve (CFVR) in patients with a history of gestational diabetes (GDM). This study aimed to assess the glomerular filtration rate (GFR) and compare CFVR in patients with a history of GDM. We screened patients referred to the Cardiology Department of Istanbul Medeniyet University for angina pectoris, excluding those with positive treadmill test results. Women with a history of GDM were categorized into three groups based on GFR levels: Group 1 (60-89 ml/min), Group 2 (90-119 ml/min), and Group 3 (≥ 120 ml/min). Coronary diastolic peak velocities were measured at baseline and after dipyridamole administration, with CFVR defined as the ratio of hyperemic to baseline diastolic peak velocities. The homeostasis model assessment of insulin resistance (HOMA-IR) and body mass index were derived from patient files. A total of 166 patients were included: 57 in Group 1, 80 in Group 2, and 29 in Group 3. HOMA-IR was higher in Group 3 compared to Group 2 (P < 0.05). Group 1 had the lowest CFVR (2.3 ± 0.3%), Group 2 had the highest (2.5 ± 0.3%), and Group 3 showed a moderate decrease in CFVR (2.4 ± 0.3%). Multivariate linear regression analysis revealed that HbA1c was independently associated with CFVR. In patients with GDM, GHF is associated with reduced CFVR, linked to metabolic parameters such as HbA1c and HOMA-IR. Interventions to improve metabolic health may prevent cardiovascular disease in these patients.
Serum cytokine profiles in children with IgA vasculitis with nephritis
Authors: Jin Yanyan , He Xue , Lin Weiqiang , Peng Zhaoyang , Li Wei , Xiang Wenqing , Chen Zhihui , Fu Haidong , Mao Jianhua
Published: September 2024

This study aimed to discover novel serum biomarkers for IgA vasculitis with nephritis (IgAVN). The serum of IgA vasculitis (IgAV) patients without nephritis and IgAVN patients not treated with glucocorticoids was analyzed for 440 proteins using a novel quantitative planar protein microarray. To verify the biomarkers, semiquantitative immunofluorescence analysis was performed on selected differential cytokines in a separate cohort of kidney tissue samples. A total of 41 proteins were differentially expressed between the IgAVN and IgAV groups out of the 440 proteins analyzed. Five differentially abundant proteins, including VEGF R3, ADAM12, TIM-3, IL-12p40, and CEACAM-5, were further validated by semiquantitative immunofluorescence analysis in kidney tissue from independent cohorts. ADAM12, TIM-3, IL-12p40, and CEACAM-5 were expressed in kidney tissue. A linear relationship was observed between the pathological grade of IgAVN and the expression levels of ADAM12 and CEACAM-5. Furthermore, while the prognosis of children with IgAVN may have a linear relationship with CEACAM-5, the results did not indicate a significant statistical difference, which may be related to the sample size. The expression of ADAM12 and CEACAM-5 were positively correlated with the pathological grade. More importantly, we found that CEACAM-5 may be related to the prognosis of IgAVN, which could serve as a significant biomarker for assessing disease severity and monitoring disease progression.
Opinión de padres y entrenadores sobre las reglas de competición actuales y modificadas en el fútbol para la promoción de valores
Authors: Madrid-Pedreño Javier , Gimenez-Egido Jose Maria , Ortega Toro Enrique
Published: September 2024

The current competitive systems in soccer are not, in many cases, the ideal ones to achieve an adequate teaching-learning process because they are inadequate to the characteristics and preferences of the children. The objectives of this work are to design and validate a questionnaire, so that it allows, secondly, to know the opinion of a group of parents and coaches about the degree of satisfaction with the current federative rules, those modified in the internal league of values of FC Cartagena and the benefits they consider from the new rules. For this, a questionnaire was designed and validated, by an expert group (16.3 ± 8.74 years of experience), which was administered to 21 coaches (age = 29.9±8.56 years and 6.90±6.73 years of experience) and 57 parents (age = 40.5±10.5 years) from the under 10 (41,65%) and under 12 (58,35%). The results showed that, despite showing general satisfaction with the current rules, they considered the modified regulation better with more appropriate rules for children to achieve improvements in the teaching-learning process and in the promotion of values. The rules of the internal league of values can be used by clubs and federations to implement a competitive system that allows greater personal development, thus allowing a competitive balance by being structured by levels and an increase in motivation, to achieve greater participation and equal opportunities than the competitive systems proposed by the federation.
Factores motivacionales, autoestima e intención de ser físicamente activo en el alumnado de formación profesional de modalidad deportiva
Authors: Camacho Carranza Ángel , Almagro Bartolomé J.
Published: September 2024

The primary objective of this study was to predict the influence of teachers' interpersonal motivational climate, the satisfaction of basic psychological needs, and the motivation of vocational training students in physical-sport activities on their intention to be physically active and their self-esteem. A questionnaire was administered to a sample of 427 students (Mage = 19.04; SD = 2.69) enrolled in programs such as Technician in Natural Environment and Leisure Time Guide, Higher Technician in Physical Conditioning, and Higher Technician in Sports Education and Animation. The results of the regression analysis showed that competence, identified regulation, external regulation, and self-perception of physical condition predicted the intention to be physically active. Moreover, competence, relatedness, and self-perception of physical condition predicted students' self-esteem. In conclusion, enhancing physical fitness through physical-sport activities and satisfying the need for competence can boost both the intention to remain active and the self-esteem of students.
Male role norms and development of PTSD among Polish male paramedics v1
Authors: Sitko-Dominik Magdalena , Jakubowski Tomasz , Mandal Eugenia
Published: September 2024

The aim of the study is to assess a potential relationshipbetween PTSD symptoms, trauma-related data, social relations/support,compliance with masculinity norms and sociodemographic data.Potentialpredictors of PTSD symptoms (social/relations/support, trauma-related andsociodemographic data, the level of compliance with masculinity norms) intensitywill also be investigated, and intergroup differences will be analyzed betweenmale paramedics who meet the criteria for PTSD and those who do not in the levelof perceived social support and compliance with traditional masculinity norms.
Annotation for Fungi v2
Authors: Bassi Sebastian , Gonzalez Virginia , Yang Tristan
Published: September 2024

Protocol to annotate a fungi genome
Pan-microbial metagenomics protocol v1
Authors: Alcolea-Medina Adela , Blagdon Snell Luke , Alder Chris , Batra Rahul
Published: September 2024

Please remember to cite the original manuscript: Alcolea-Medina et al. Unified metagenomic method for rapid detection of microorganisms in clinical samples. Commun Med (Lond). 2024 Jul 7;4(1):135. doi: 10.1038/s43856-024-00554-3. PMID: 38972920
Poly(A)-ClickSeq: Poly(A)-Primed Protocol with Single Indexing using Poly(A)-ClickSeq Kit v1
Authors: Routh Andrew , Jaworski Elizabeth
Published: September 2024

Poly(A)-ClickSeq is a library preparation method used to target the 3’ ends of polyadenylated RNA, such as eukaryotic mRNAs. This technique offers an alternative to conventional RNA-seq methods that provide the user with sequencing reads that cover entire transcripts. Instead, the 3’ end targeting protocol of Poly(A)-ClickSeq enables a more cost efficient and straightforward method for measuring differential gene expression and simultaneously the mapping of poly(A) sites which can be used for alternative polyadenylation studies. The process takes advantage of the chain-terminating properties of 3′-azido-nucleotides, which are included the initial in vitro reverse-transcription reactions uniformly required for RNAseq. In Poly(A)-ClickSeq (PAC-Seq), priming occurs from poly(A)-tails using an unanchored oligo-dT primer and only AzATP, AzGTP and AzCTP (collectively known as AzVTPs) are supplemented in the RT reaction. As a result, cDNA synthesis does not terminate in the poly(A)-tail, but rather continues until the 3’UTR is reached. Thereafter, the modified nucleotides (AzVTPs) are stochastically incorporated into the nascent cDNA at a programmable distance upstream of the 3’UTR/Poly(A)-tail junction, yielding cDNA fragments blocked at their 3′ends with azido groups. The 3′-azido-blocked cDNA fragments are ‘click-ligated’ onto alkyne-functionalized sequencing adaptors, which can subsequently be PCR-amplified to yield a sequencing-ready NGS library. PAC-Seq offers unique advantages over common RNA sequencing and 3’end mapping protocols in that it does not require the purification, selection, or fragmentation steps typically required in RNA-seq approaches. Sample preparation is started directly from crude total cellular RNA. Furthermore, click-chemistry is utilized to attach the required sequencing adapter, rather than commonly-used enzymatic reactions. Overall, this results in increased efficiency of the protocol, fewer processing steps, and reduced time from RNA to sequencing-ready libraries.
Environmental DNA (eDNA) indexing PCR protocol at MSU v1
Authors: Baker Jacoby , Pitz Kathleen
Published: September 2024

This sequencing protocol is intended to directly follow and use the PCR products of a primary PCR amplification protocol (e.g., 12S rRNA, 18S rRNA V9, cytochrome c oxidase subunit I (COI) mitochondrial gene). Primary PCR products were produced at MBARI and sent to Michigan State University's (MSU) Research Technology Support Facility (RTSF) Genomics Core for indexing, pooling, and sequencing. Secondary PCR primers used: PE1-BC-CS1, PE2-BC-CS2 This indexing PCR protocol is used to uniquely index the amplified DNA products of each sample. This is necessary so the sequencing results can be demultiplexed and the reads can be properly identified and assigned to each individual sample.
Readiness of Indonesian TVET Teachers in Receiving GIS Technology Using TAM 2
Authors: Bakri Arya , Sugiarti Yatti , Wahyudin Didin
Published: September 2024

Since the enactment of curriculum changes in 2013, several factors have emerged that often become obstacles in geographic and geospatial technical vocational high schools in Indonesia, one of which is minimal acceptance of Geography Information System (GIS) technology. This teacher survey research is to explore the determinant factors that influence the acceptance of GIS technology, through identifying what obstacles are found when the acceptance of GIS technology is integrated in classroom learning. Using survey data from 94 teachers from 34 geographic and geospatial technical vocational schools, question assumptions were formulated using the technology acceptance model (TAM 2), with key determinants of Perceived Usefulness (PU) and User Intention (UI). The lack of knowledge, skills and experience of teachers following GIS training, has caused teachers to be slow in accepting GIS technology. These pressures prevent teachers from reflecting on their teaching, and ultimately result in substitution of teachers intellectual creativity with compliance culture and contribute to the tendency of teachers to prioritize learning experiences that they believe can be directly applied to their own classroom situations. It is clear that the benefits of implementing a classroom will not come alone if the teacher is not ready and trained for the use of GIS technology.
Quality Assurance Practices in Public Technical and Vocational Education and Training Institutions in the Khartoum State-Sudan
Authors: Gasmelseed Ahmed Mansour Mohammad
Published: September 2024

The primary purpose of this study was to examine the quality assurance practice of public TVET institutions in Khartoum State and its challenges and prospects. To this end, the study used an explanatory sequential mixed method design. The researcher chooses 285 teachers and 491 students from 12 TVET institutions to complete the study questionnaire using stratified and simple random sampling. Descriptive (mean scores, standard deviation) and inferential statistics used to analyze quantitative data (two-sample t-test, multiple regression analysis). Also, the researcher interviewed all of the selected TVET institution managers, technical education directors, and SCVTA for qualitative data. Besides, six teachers and nine students participated in a focus group discussion, accompanied by an observational checklist for the quantity and quality of selected input resources. Documentary analyses for TVET policy documents were also used. According to the study's findings, the amount of materials and services available at Khartoum state TVET institutions is insufficient. In TVET institutions, the input quality was poor. Students had high expectations and perceptions of TVET.  It was suggested that the authorities: formulate specific policies and plans for TVET, allocate the appropriate budget, and monitor the plan's implementation; form a collaboration between industry and TVET to help students and compensate for training deficiencies, and pay more attention to teacher training and motivation by meeting their needs.
Exploring yearly vocational graduate career development, article citation and top publications
Authors: Aghniya Salsabila Manna , Nofri Bunga Arnelia , Saadah Nur Aini , Ayu Mahesa , Handayani Mustika Nuramalia
Published: September 2024

There has been a lot of research on career development, including during the COVID-19 period, but the number of studies that specifically analyze related developments from year to year is increasingly limited. This study aims to determine the development of research that focuses on career development of vocational graduates by using the bibliometric analysis method. The analysis was conducted by collecting articles published in Scopus indexed journals. Publication data collection was carried out using Scopus journals. VOSviewer application to create bibliometric network visualization. The results of the analysis show that the United States is a country that contributes the largest number of publications that discuss career development in the world. Center for International Research on Education Systems, Victoria University, Melbourne, Australia is the first institution to publish about career development among the top 10 institutions.
Producción científica sobre archivos digitales en Latinoamérica según Scopus en el período 2018-2022
Authors:   Universidad Técnica de Manabí, Quiroz-Álava Teresa Stefania , Moreira-Mieles Liggia Lisbeth ,   Universidad Técnica de Manabí, Quindemil-Torrijo Eneida María ,   Universidad Técnica de Manabí, Rumbaut-León Felipe ,   Universidad Técnica de Manabí
Published: September 2024

Los archivos digitales surgieron como una alternativa para almacenar, organizar, conservar, acceder y compartir información en formato digital. Su uso generalizado en diferentes ámbitos, como la educación, la investigación, la industria y la administración, ha transformado la manera en que se maneja la información y ha mejorado su eficiencia y su accesibilidad. El objetivo de la investigación fue analizar la producción científica sobre archivos digitales en Latinoamérica según Scopus en el periodo 2018-2022. Se realizó un estudio descriptivo con enfoque cuantitativo y un análisis bibliométrico a través de indicadores centrados en describir la producción científica para determinar el impacto de estas publicaciones, con base en la recopilación y análisis de datos bibliográficos. Los resultados del estudio mostraron la existencia de un constante interés en este tema, considerando la cantidad de publicaciones recuperadas. Destaca la productividad científica de Brasil en la región y el predominio de artículos de revista. Se evidenció el progresivo crecimiento en la cantidad de investigaciones en el periodo analizado, y la preponderancia de trabajos en idioma inglés. Los hallazgos confirmaron la estrecha relación entre las temáticas más citadas y el campo de los archivos digitales, lo que reafirma el valor de la investigación en el contexto actual.
Regeneration in Vulnerable Communities: Resident and Stakeholder Perspectives
Authors: O'Sullivan Siobhan , O'Connell Cathal , Cullinane Mark , Kenny Lorna , Folan O’Connor Elizabeth , Gaston Sadhbh
Published: September 2024

This article assesses the implementation of a regeneration programme in a disadvantaged area in the south of Ireland, with particular focus on how residents in vulnerable circumstances have been supported in the face of multiple crises including economic recession and austerity, service reductions and cutbacks, risk of poverty and social exclusion, and neighbourhood change. The article draws on longitudinal qualitative and quantitative data generated over the time frame of a decade through research with residents, community organisations, and the municipal authority. Drawing on the principles of sustainable regeneration, i.e., physical, social, economic, and environmental dimensions, the article explores the effectiveness and outcomes of regeneration strategies on improving estate liveability and the quality of life of residents across multiple themes and indicators. The key themes explored include supports across the life course, community safety and public realm, education and opportunity, and well‐being and resilience. Through this analysis, the article aims to better understand the experiences of residents in vulnerable circumstances and the impacts, both positive and negative, of a major regeneration programme on their lives.
Cyclosporine combined with eltrombopag for treatment of secondary graft failure after autologous hematopoietic stem cell transplantation
Authors: Semochkin S. V. , Lunin V. V. , Kaplanskaya I. B. , Fedenko A. A.
Published: September 2024

Graft failure (GF) is an extremely rare complication of autologous hematopoietic stem cell transplantation (auto-HSCT) with a frequency not exceeding 3–5 % of all cases of this technology. Primary graft failure is distinguished when restoration of hematopoiesis has not occurred by day +28 after hematopoietic stem cell transfusion, and secondary GF, implying the occurrence of neutropenia <0.5 × 109 /L after successful initial engraftment, which cannot be explained by tumor relapse, infections or chemotherapy toxicity.

In this report, we present a clinical case of a 57-year-old woman with newly diagnosed diffuse large B-cell lymphoma with multiple lesions of the skeletal bones and lymph node involvement on both sides of the diaphragm. A feature of this case of diffuse large B-cell lymphoma was the secretion of monoclonal IgGκ and plasmacytoid differentiation of tumor cells. Firstline therapy with 6 cycles of R-CHOP was unsuccessful. A complete metabolic response according to positron emission tomography combined with computed tomography (PET/CT) was obtained after 2 cycles of second-line R-DHAP therapy, followed by myeloablative consolidation and transfusion of 16.9 × 106/kg CD34+ autologous hematopoietic stem cells. The patient was discharged from the hospital on day +15 with stable restoration of hematopoiesis. The pancytopenia and aplasia of bone marrow hematopoiesis developed across 3 months after auto-HSCT. For secondary GF, the patient received G-CSF, transfusions of blood components, and treatment similar to that for aplastic anemia (cyclosporine 5 mg/kg plus eltrombopag). A partial hematological response was obtained within 9 months, and a complete response by 24 months of therapy. According to PET/CT data 36 months after auto-HSCT, the patient had a local increase in the level of 18F-fluorodeoxyglucose fixation (maximum standardized uptake value 3.33), possibly of an inflammatory nature, in the body of the L4 vertebra on the background of bone cement after vertebroplasty performed at the onset of the disease. In addition, monoclonal secretion of IgGκ persists in the absence of immunomorphological evidence of bone marrow involvement.

In conclusion, the article discusses the possible causes of the monotonous monoclonal IgGκ secretion and presents a literature review of known GF treating methods.
Clinical significance of infections caused by human 6A and 6B herpes viruses in allogeneic hematopoietic stem cells recipients in the post-transplant period
Authors: Saydullayeva I. S. , Tupoleva T. A. , Tikhomirov D. S. , Drokov M. Yu.
Published: September 2024

Allogeneic hematopoietic stem cells transplantation is an effective method for the treatment of hematologic malignancies and other blood system diseases. Infections caused by human 6A and 6B herpes viruses are one of the leading causes of complications and mortality in hematology patients after allogeneic hematopoietic stem cell transplantation, especially in the first 100 days after transplantation. This review discusses the clinical features of infections caused by human herpes viruses 6A and 6B, their impact on the development of post-transplant complications, including graft-versus-host disease and graft failure, as well as methods of prevention and treatment.
Complement C3 inhibitor in patients with paroxysmal nocturnal hemoglobinuria with suboptimal response to C5 inhibitor therapy
Authors: Marchenko M. V. , Klimova O. U. , Anikina E. V. , Lapina A. V. , Rudakova T. A. , Ksenzova T. I. , Kulagin A. D.
Published: September 2024

The introduction of the complement component C5 inhibitor eculizumab has radically changed the prognosis and quality of life of patients with paroxysmal nocturnal hemoglobinuria. Up to 30 % of patients develop only a suboptimal response to C5 inhibition. One reason for this is activation of extravascular hemolysis, due to opsonization of erythrocytes with fragments of the C3 component. Pegcetacoplan, the first ever registered C3 inhibitor, is aimed at solving this problem.

In Russia, 2 patients received pegcetacoplan as part of a phase 3, randomized, open-label, active-comparator controlled trial PEGASUS. The analysis includes data from the first year of therapy: the run-in period (pegcetacoplan 1080 mg SC twice weekly in addition to the current dose of eculizumab, 4 weeks), the randomized controlled period (both patients were randomized to eculizumab monotherapy, 16 weeks), and the open-label period of pegcetacoplan therapy (32 weeks). Data from the extension study to evaluate the long-term safety and efficacy of pegcetacoplan are also presented. The duration of follow-up on pegcetacoplan therapy in both patients exceeded 4 years.
Treatment efficiency in patients with acute myeloid leukemia from 2019 to 2023 according to the Moscow Cancer Registry
Authors: Tolstykh T. N. , Misyurina E. N. , Mingalimov M. A. , Baryakh E. A. , Zhelnova E. I. , Gagloeva D. E. , Kardovskaya S. A. , Chudnova T. S. , Zotina E. N. , Ivanova D. D. , Kochneva O.  L. , Yatskov K. V. , Shimanovskaya L. T. , Mar’in D. S. , Makeshova A. B. , Chernova N. G. , Dudina G. A. , Granatkin M. A. , Semina T. A. , Misyurin A. V. , Lysenko M. A.
Published: September 2024

Aim. To evaluate the acute myeloid leukemia (AML) treatment efficacy in adults in Moscow real clinical practice according to the Moscow Cancer Registry data.

Materials and methods. We retrospectively collected data from the Moscow Cancer Registry on Moscow permanent residents who were primary diagnosed with AML from January 2019 to November 2023. The effectiveness of antitumor therapy was assessed by the complete remissions rate, relapses, deaths, and 3-year overall and relapse-free survival. Data analysis performed as of 01.12.2023.

Results. According to the Moscow Cancer Registry, from 01.01.2019 to 01.12.2023, the diagnosis of AML (except for acute promyelocytic leukemia) was established in 752 patients with a median age at the time of diagnosis of 64 (19– 94) years. In the studied sample, females slightly predominated: women – 56.6 % (n = 426), men – 43.4 % (n = 326). Of all patients included in the study, 36 % (n = 275) received intensive chemotherapy, while 57 % (n = 427) received low-intensity chemotherapy, and the remaining 7 % (n = 50) patients received best supportive care. Early mortality (first 60 days) in the total group was 16 % (n = 123), 20 % (n = 149) of patients were refractory to the therapy. Complete remission was achieved by 63 % (n = 473) of patients: 82 % (n = 225) of them received intensive chemotherapy, 58 % (n = 248) – low-intensity chemotherapy. Relapses occurred in 41 % (n = 194) of 473 patients who achieved complete remission. In the first remission, allogeneic hematopoietic stem cell transplantation was performed in 11 % (n = 79) of patients. With a median follow-up of 30.1 months, the 3-year overall survival in total group was 27 % (95 % confidence interval 23–32), and the 3-year relapse-free survival was 44 % (95 % confidence interval 37–51).

Conclusion. The main problem in the treatment of adult AML patients remains high induction mortality and limited opportunities for allogeneic hematopoietic stem cell transplantation in real clinical practice, which emphasizes the need to develop transplant centers in Moscow.
Prediction of the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer based on a texture analysis of T2-weighted magnetic resonance tumor image obtained at primary staging
Authors: Dayneko Yana A. , Berezovskaya Tatiana P. , Mirzeabasov Oleg A. , Starkov Sergey O. , Myalina Sofiya A. , Nevolskikh Aleksey A. , Ivanov Sergey А. , Kaprin Andrey D.
Published: September 2024

BACKGROUND: Recently, significant efforts have been undertaken to find potential noninvasive biomarkers for predicting the response of locally advanced rectal cancer to neoadjuvant chemoradiotherapy.
AIM: To assess the texture characteristics of locally advanced rectal cancer in primary T2-weighted imaging (T2-WI) as a potential predictor for the efficacy of standard neoadjuvant chemoradiotherapy and develop a prediction system for the efficacy of neoadjuvant chemoradiotherapy based on them.
MATERIALS AND METHODS: The retrospective study enrolled 82 patients with locally advanced rectal cancer who received combination treatment with neoadjuvant chemoradiotherapy. Patient data were divided into the training (n=58) and control (n=24) sets. For texture analysis, primary high-resolution T2-WI at the level of the tumor center, oriented perpendicular to the intestinal wall, was used. The texture analysis was performed by second-order statistics based on the gray-level co-occurrence matrices using MAZDA ver. 4.6 featuring the calculation of 11 texture parameters. In the training set, based on the morphological assessment of surgical specimens, significantly different texture analysis parameters were found for two groups of patients: neoadjuvant chemoradiotherapy responders (good prognosis group) and nonresponders (poor prognosis group). Accordingly, a scoring system was created for assessing the efficacy of neoadjuvant chemoradiotherapy. The system was tested on the control set, and diagnostic efficacy parameters were determined.
RESULTS: In the training set, the good and poor prognosis groups differed significantly in five texture parameters: AngScMom (p=0.021), SumofSqs (p=0.003), SumEntrp (p=0.003), Entropy (p=0.038), and SumVarnc (p=0.015), for which the cutoff points were found. These parameters were applied to create the scoring system (excluding the Entropy parameter, which had a strong direct correlation with SumEntrp and the lowest area under the curve, and SumofSqs, which had low reproducibility). The diagnostic efficiency of the scoring system for predicting the response had sensitivity, specificity, positive-predictive value, and negative- predictive value of 72%, 69%, 70%, and 71% for the training set and 80%, 64%, 62%, and 82% for the control set, respectively. The areas under the ROC curve were 0.77 and 0.72 for the training and control sets, respectively.
CONCLUSIONS: Texture analysis of the primary T2-WI of tumors in patients with locally advanced rectal cancer allows for predicting the efficacy of neoadjuvant chemoradiotherapy with moderate diagnostic efficiency. The results suggest good prospects for further research in this area.
Pengaruh Pembelajaran Berdiferensi terhadap Persiapan Mengajar Mahasiswa PPG Prajabatan Bidang Studi Bahasa Indonesia
Authors: Toto Bagas Dwi Has , Sulistyorini Dwi
Published: September 2024

Kurangnya pemahaman mahasiswa dalam pembelajaran belum sesuai dengan kebutuhan belajarnya kemudian dapat berdampak terhadap rendahnya tingkat hasil belajar siswa. Pembelajaran yang baik dapat dilakukan dengan mengetahui karakteristik dan kebutuhan belajar siswa. Mahassiswa perlu memahami empat konsep kunci dalam pembelajaran yang berdiferensiasi konten, proses, produk, dan lingkungan belajar. Tujuan penelitian ini adalah untuk mengetahui seberapa baik mahasiswa Pendidikan Profesi Guru memahami pembelajaran berdiferensiasi dalam konteks persiapan mengajarnya. Penelitian ini menggunakan metodologi deskriptif dan bersifat kualitatif. Observasi langsung merupakan metode yang digunakan untuk mengumpulkan data, disertai dengan wawancara dan kegiatan perkuliahan. Subjek yang terlibat dalam penelitian ini yakni mahasiswa Pendidikan Profesi Guru Gelombang 2 Universitas Negeri Malang bidang studi bahasa Indonesia berjumlah 26 orang mahasiswa dan 1 dosen mata kuliah. Hasil penelitian menunjukan persiapan keterampilan mengajar mahasiswa mengalami peningkatan setelah mendapatkan pembelajaran berdiferensiasi. Persiapan mengajar mahasiswa Pendidikan Profesi Guru mengalami perubahan dapat dilihat dari proses praktik mengajar di lingkungan sekolah. Peningkatan keterampilan mengajar dapat berpengaruh terhadap hasil belajar siswa.
PENGEMBANGAN E-MODUL INTERAKTIF PADA MATERI DAMPAK SOSIAL INFORMATIKA KELAS VII SMP
Authors: Adi Prastowo Nur Kodrad , Handayani Anik Nur , Arif Widodo Baskoro
Published: September 2024

Kegiatan pembelajaran di kelas acap terjadi peserta didik enggan mengikuti proses pembelajaran yang disampaikan oleh guru karena media yang digunakan tidak menarik bagi peserta didik.Penelitian ini bertujuan untuk mengembangkan e-modul interaktif yang berfokus pada materi dampak sosial informatika kelas vii SMP. Pengembangan E-modul Interaktif diharapkan dapat menjadi alternatif media pembelajaran menarik yang dapat membantu guru menyampaikan materi dengan lebih baik sehingga meningkatkan pemahaman peserta didik terhadap materi yang disampaikan dan memahami dampak sosial informatika dengan baik. E-modul interaktif ini diharapkan dapat memfasilitasi peserta didik untuk belajar secara mandiri, praktis dan efektif . Penelitian ini diharapkan dapat memberikan dampak positif bagi pendidikan dengan pemanfaatan teknologi guna meningkatkan minat belajar peserta didik.
PENGARUH PENGGUNAAN SMARTPHONE DALAM PEMBELAJARAN TERHADAP KOMPETENSI SOSIAL EMOSIONAL DAN MINAT BELAJAR PESERTA DIDIK SMP
Authors: Puspitaning Ayu Christina , Susanto Hery , Pangastuti Sri
Published: September 2024

Perkembangan teknologi di era globalisasi yang berkembang dengan pesat mampu membawa perubahan tidak hanya dalam kehidupan bermasyarakat namun juga dalam dunia pendidikan. Perkembangan teknologi yang telah membudaya dalam kehidupan maupun dalam suni pendidikan masa kini adalah smartphone. Penggunaan smartphone dalam pembelajaran mampu memberikan pengaruh terhadap peserta didik. Pengaruh tersebut diulas pada penelitian ini dengan tujuan penelitian adalah untuk mendeskripsikan pengaruh penggunaan smartphone dalam pembelajaran terhadap kompetensi sosial emosional peserta didik dan minat belajarnya. Penelitian ini menggunakan penelitian metode deskriptif dengan pendekatan kualitatif. Pengumpulan data dilakukan dengan teknik observasi dan wawancara kepada peserta didik salah satu kelas IX di SMP Negeri 11 Malang. Berdasarkan peneltitian ini dapat disimpulan dari bahwa penggunaan smartphone dalam pembelajaran memiliki pengaruh yang besar yakni pengaruh positif terhadap kompetensi sosial emosional peserta didik dan minat belajarnya
PENGEMBANGAN BAHAN AJAR BERDIFERENSIASI KONTEN PADA MATERI ALGORITMA DAN PEMROGRAMAN KELAS VII SMP
Authors: Aprilianto Pratama
Published: September 2024

Tujuan penelitian ini adalah mengembangkan bahan ajar berdiferensiasi konten materi algoritma dan pemrograman untuk kelas VII SMP. Latar belakang penelitian ini didasarkan pada pentingnya pendekatan berdiferensiasi konten dalam pembelajaran, terutama untuk memenuhi kebutuhan beragam peserta didik dalam kelas. Metode pengembangannya adalah Research and Development (R&D) menggunakan model ADDIE (Analyze, Design, Development, Implement, Evaluation). Penelitian ini melakukan uji validasi ahli media dan materi yang berguna memastikan kualitas dan keefektifan bahan ajar yang dikembangkan. Hasil pengembangan menunjukkan bahwa bahan ajar berdiferensiasi konten pada materi algoritma dan pemrograman dapat meningkatkan pemahaman peserta didik serta menghasilkan peningkatan prestasi belajar mereka
PENGARUH KURIKULUM PADA KUALITAS LULUSAN SMK TERHADAP PENYERAPAN DI DUNIA KERJA
Authors: Puspitasari Leony , Ichwanto Muhammad Aris , Ramadhani Muhammad Rifqi , Ramadhan Muhammad Wahyu , Murtadho Muhammad Syifaul
Published: September 2024

Abstrak : Kurikulum pada dunia pendidikan merupakan suatu hal yang perlu dipikirkan matang-matang agar dapat menghasilkan lulusan berkualitas. SMK merupakan merupakan suatu sekolah menengah yang kurikulumnya perlu diperhatikan dan ditingkatkan agar dapat menghasilkan lulusan yang siap terjun kedunia industri. Kurikulum yang relevan dengan kondisi yang ada juga perlu. Kurikulum juga kerap kali mengalami perubahan seiring dengan perkembangan zaman yang semakin maju. Kematangan peserta didik diperlukan agar peserta didik mampu bersaing didunia industri.
ANALISIS PENGARUH TIPE RANGKA WARREN, PRATT, HOWE, DAN K-TRUSS TERHADAP EFISIENSI JEMBATAN RANGKA BAJA BENTANG 80 M
Authors: Putri Nadiyah Mulia , Nindyawati Nindyawati
Published: September 2024

Abstrak : Penelitian ini bertujuan untuk memperoleh pengaruh tipe rangka terhadap efisiensi jembatan berdasarkan nilai DCR (Demand Capacity Ratio), berat total struktur, nilai lendutan, dan nilai efisiensi. Penelitian ini menggunakan metode penelitian komparatif. Rancangan dari penelitian ini diawali dengan permodelan struktur jembatan menggunakan program SAP2000 dengan analisis pembebanan jembatan sesuai SNI 1725-2016 dan kontrol profil baja elemen batang jembatan sesuai RSNI T-03-2005 dan SNI 1729-2020. Tipe rangka yang dibandingkan adalah warren, pratt, howe, dan k-truss. Bentang jembatan 80 m dengan tinggi 8 m dan lebar 9 m. Mutu baja menggunakan SNI 07-2610-2011 BJ PHC 540 untuk profil baja H-beam dan JIS G3101-SS400 untuk profil IWF. Nilai efisiensi jembatan ditentukan dengan rumus perkalian berat total struktur dan lendutan maksimum jembatan. Semakin kecil nilai efisiensi jembatan maka semakin efektif kinerja struktur jembatan tersebut. Hasil penelitian menunjukkan bahwa nilai DCR pada setiap tipe rangka memiliki pola grafik yang relatif sama pada daerah gelagar dan berbeda pada daerah sistem truss (rangka utama). Tipe rangka yang terberat adalah warren sebesar 161,77 ton, sedangkan yang teringan adalah k-truss sebesar 153,38 ton. Tipe rangka pratt dan howe mempunyai berat total struktur yang sama yaitu 154,54 ton. Tipe rangka yang mempunyai lendutan maksimum yang terkecil adalah k-truss sebesar 0,05227 m, sedangkan yang terbesar adalah pratt sebesar 0,05472 m. Tipe rangka yang mempunyai nilai efisiensi terkecil adalah k-truss sebesar 8,0172, sedangkan yang terbesar adalah warren sebesar 8,6968. Sehingga dapat diidentifikasi bahwa jembatan yang paling efisien dalam penelitian ini adalah jembatan dengan tipe rangka k-truss.
Indonesia Berpetualang ke Dunia Digital: Society 5.0
Authors: Ega Wijaya Mikel , Wibawa Aji
Published: September 2024

Society 5.0 offers a platform where technology and innovation can enhance societal well-being by utilizing data and artificial intelligence to solve social issues. In the era of Society 5.0, Indonesia is faced with technology that enables virtual access as if it were physical access. AI based on big data and robots are utilized to support human labor in Society 5.0 technology. In this "new" world, digitalization, virtuality, and continuous internet access have become common for most of the world's population. In the face of the digital era and rapid technological advancements, Indonesia needs to take action. As a country with the world's largest population, it is crucial for Indonesia to utilize technology and innovation to improve the quality of life and societal well-being. Despite these challenges, Indonesia also has enormous potential to utilize technology and innovation in various sectors such as education, healthcare, and agriculture. Therefore, a joint effort between the government, industry, and society is needed to overcome these challenges and accelerate digital transformation in Indonesia to achieve maximum benefit from the potential of Society 5.0 in Indonesia.
Society 5.0 menawarkan di mana teknologi dan inovasi dapat meningkatkan kesejahteraan masyarakat dengan menggunakan data dan kecerdasan buatan untuk memecahkan masalah  sosial. Dalam era Society 5.0, Indonesia berhadapan dengan teknologi yang memungkinan akses ke tempat virtual seakan-akan seperti akses ke tempat fisik. AI berbasis big data dan robot digunakan untuk memberikan dukungan pada pekerjaan manusia. dalam teknologi Society 5.0. Di dunia "baru" ini, digitalisasi, virtualitas, dan akses internet yang terus-menerus telah menjadi hal yang umum bagi sebagian besar populasi dunia. Di hadapan era digital dan perkembangan teknologi yang pesat, Indonesia perlu mengambil tindakan. Sebagai sebuah negara yang memiliki populasi jumlah penduduk terbesar di dunia, dalam memanfaatkan teknologi dan inovasi untuk meningkatkan kualitas hidup dan kesejahteraan masyarakatnya.Namun dibalik tantangan tersebut, Indonesia juga memiliki potensi besar pada pemanfaatan teknologi dan inovasi dalam berbagai sektor seperti pendidikan, kesehatan dan pertanian. Oleh karena itu, dibutuhkan upaya bersama antara pemerintah, industri, dan masyarakat untuk mengatasi tantangan tersebut dan mempercepat transformasi digital di Indonesia agar dapat meraih manfaat maksimal dari Potensi Society 5.0 di Indonesia.
Smartphone Donation for Education: A Technopreneurship’s Approach in Indonesian Case Study
Authors: Halim Siana , A.Y. Aysia Debora , Lestari Jessi , Shu San Gan
Published: September 2024

This paper proposed a smartphone donation to help Indonesian students in remote areas and students who needed help, such as students in orphanages in Indonesia, using the technopreneurship approach. The technopreneurship steps that we used in this study started with collecting data through a questionnaire to know the willingness of Indonesians to donate and their preferences in donating their used smartphones. We found that 78.7% of the respondents are eager to donate, and they trust the social, educational, and religious institutions as trusted, credible institutions as places for collecting used smartphones. However, online channels are more convenient for them to donate, followed by donations through religious institutions such as mosques, churches, viharas, and temples. As a result, a business model canvas and a business process are constructed to answer the eagerness of Indonesians to donate their used smartphones.
Penelitian ini mengusulkan donasi smartphone untuk membantu pelajar Indonesia di daerah terpencil dan pelajar yang membutuhkan bantuan, seperti pelajar di panti asuhan di Indonesia, dengan menggunakan pendekatan technopreneurship. Langkah-langkah technopreneurship yang kami gunakan dalam penelitian ini dimulai dengan mengumpulkan data melalui kuesioner untuk mengetahui kesediaan masyarakat Indonesia untuk berdonasi dan preferensi mereka dalam mendonasikan smartphone bekas mereka. Kami menemukan bahwa 78,7% dari responden sangat ingin berdonasi, dan mereka mempercayai lembaga-lembaga sosial, pendidikan, dan keagamaan sebagai lembaga yang terpercaya dan kredibel sebagai tempat pengumpulan smartphone bekas. Namun, saluran online lebih nyaman bagi mereka untuk berdonasi, diikuti oleh donasi melalui lembaga keagamaan seperti masjid, gereja, vihara, dan kuil. Hasilnya, sebuah kanvas model bisnis dan proses bisnis dibangun untuk menjawab keinginan masyarakat Indonesia untuk mendonasikan smartphone bekas mereka.
Un megaherbívoro invasor al descubierto: ecología de la población de hipopótamos (Hippopotamus amphibius) en Colombia
Authors: Moreno-Arias Rafael , Nova-León Laura J. , García-Loaiza Lina M. , Baptiste-Espinosa Maria P. , Montenegro-Díaz Olga L. , López-Arévalo Hugo F. , Loaiza Camilo , Santamaría-Castiblanco David , Díaz-Rodríguez Gina
Published: September 2024

Debido a las condiciones climáticas y ecológicas favorables de los ecosistemas colombianos, la población de hipopótamos introducida en los años 80 en el país, se ha incrementado y ahora se distribuye desde el valle medio del río Magdalena en Antioquia hasta la depresión momposina en Bolívar. Recientemente, el gobierno nacional declaró al hipopótamo como una especie invasora por los efectos negativos que causa su presencia en los ecosistemas, los medios de subsistencia y la vida de las personas. Se hizo un extenso estudio demográfico para determinar el tamaño y la estructura de la población de hipopótamos, describir su distribución espacial y proyectar su dinámica poblacional futura. Usando múltiples técnicas, se obtuvieron registros directos e indirectos que permitieron estimar una población de al menos 181 hipopótamos distribuidos en siete grupos, de los cuales cinco se encuentran en etapas avanzadas de invasión biológica. Dada la estructura y el tamaño poblacional estimados, se espera que la población llegue a mil individuos alrededor del 2040 si no se implementan medidas urgentes para su erradicación.