bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of a bi-directional methodology for automated assessment of compliance to continuous application of clinical guidelines, and its evaluation in the type 2 diabetes domain
Authors: Hatsek Avner , Hochberg Irit , Daoud Naccache Deeb , Biderman Aya , Shahar Yuval
Published: May 2024

We introduce a new approach for automated guideline-based-care quality assessment, the bidirectional knowledge-based assessment of compliance (BiKBAC) method, and the DiscovErr system, which implements it. Our methodology compares the guideline’s Asbru-based formal representation, including its intentions, with the longitudinal medical record, using a top-down and bottom-up approach. Partial matches are resolved using fuzzy temporal logic. The system was evaluated in the type 2 Diabetes management domain, comparing it to three expert clinicians, including two diabetes experts. The system and the experts commented on the management of 10 patients, randomly selected from 2,000 diabetes patients. On average, each record spanned 5.23 years; the data included 1,584 medical transactions. The system provided 279 comments. The experts made 181 different unique comments. The completeness (recall) of the system was 91% when the gold standard was comments made by at least two of the three experts, and 98%, compared to comments made by all three experts. The experts also assessed all of the 114 medication-therapy-related comments, and a random 35% of the 165 tests-and-monitoring-related comments. The system’s correctness (precision) was 81%, compared to comments judged as correct by both diabetes experts, and 91%, compared to comments judged as correct by one diabetes expert and at least as partially correct by the other. 89% of the comments were judged as important by both diabetes experts, 8% were judged as important by one expert, and 3% were judged as less important by both experts. Adding the validated system comments to the experts’ comments, the completeness scores of the experts were 75%, 60%, and 55%; the expert correctness scores were respectively 99%, 91%, and 88%. Thus, the system could be ranked first in completeness and second in correctness. We conclude that systems such as DiscovErr can effectively assess the quality of continuous guideline-based care.
Observation system for the technical-tactical analysis of judo by the Rio 2016 Olympic champions
Authors: Soriano David , Tarragó Rafael , Lapresa Daniel , Callan Mike , Iglesias Xavier
Published: May 2024

An observational methodology system has been designed which allows the observation and analysis of the technical-tactical behaviour and interaction of judokas during competition. The observation instrument (JUTACTIC) is composed of 8 fixed criteria that provide information related to the competition and the competitors and 13 variable criteria that, throughout the intrasessional monitoring of each combat, allow the behaviour displayed by both judokas and their interaction to be recorded. From an observational sample consisting of matches from the Rio 2016 Olympic champions and the corresponding samples made using the LINCE PLUS software, evidence of validity, reliability, generalizability and applicability of the observation system is provided. The content validity of the observation instrument has been endorsed by a panel of experts (n = 11). Intra and inter-observer reliability has been guaranteed from the results obtained in the Fleiss Kappa and the Krippendorff Alpha. The generalizability analysis with the design structure [Category] [Participants] / [Matches] has confirmed that around seven matches are needed to accurately analyse the behaviour of the competitor under study. The practical application possibilities of the observation instrument has been shown with an example of the results obtained and the regular behaviour structures detected (T-patterns) using the THEME software.
Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type I
Authors: Cubero Elena , Ruano Ana , Delgado Aida , Barril Xavier , Morales Sara , Trapero Ana , Leoni Lorenzo , Bellotto Manolo , Maj Roberto , Guzmán Beatriz Calvo-Flores , Pérez-Carmona Natalia , Garcia-Collazo Ana Maria
Published: May 2024

Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal disease caused by lowered activity of the enzyme alpha-L-iduronidase (IDUA). Current therapeutic options show limited efficacy and do not treat some important aspects of the disease. Therefore, it may be advantageous to identify strategies that could improve the efficacy of existing treatments. Pharmacological chaperones are small molecules that protect proteins from degradation, and their use in combination with enzyme replacement therapy (ERT) has been proposed as an alternative therapeutic strategy. Using the SEE-Tx® proprietary computational drug discovery platform, a new allosteric ligand binding cavity in IDUA was identified distal from the active site. Virtual high-throughput screening of approximately 5 million compounds using the SEE-Tx® docking platform identified a subset of small molecules that bound to the druggable cavity and functioned as novel allosteric chaperones of IDUA. Experimental validation by differential scanning fluorimetry showed an overall hit rate of 11.4%. Biophysical studies showed that one exemplary hit molecule GT-01803 bound to (Kd = 22 μM) and stabilized recombinant human IDUA (rhIDUA) in a dose-dependent manner. Co-administration of rhIDUA and GT-01803 increased IDUA activity in patient-derived fibroblasts. Preliminary in vivo studies have shown that GT-01803 improved the pharmacokinetic (PK) profile of rhIDUA, increasing plasma levels in a dose-dependent manner. Furthermore, GT-01803 also increased IDUA enzymatic activity in bone marrow tissue, which benefits least from standard ERT. Oral bioavailability of GT-01803 was found to be good (50%). Overall, the discovery and validation of a novel allosteric chaperone for rhIDUA presents a promising strategy to enhance the efficacy of existing treatments for MPS I. The compound’s ability to increase rhIDUA activity in patient-derived fibroblasts and its good oral bioavailability underscore its potential as a potent adjunct to ERT, particularly for addressing aspects of the disease less responsive to standard treatment.
Open innovation and confidentiality agreements as key factors of innovative performance in the manufacturing and service industries
Authors: Barrios Aguirre Fernando , Alvarez Ovalle Diana Maritza , Riveros Chávez Nancy Milena , Martinez Garcia Carla Johana
Published: May 2024

The innovative performance of manufacturing and service companies can be impacted by the existing relationship between open innovation (OI) and the generation of confidentiality agreements (NDAs) as a tool for the protection of intellectual property. Based on the analysis of a cross-sectional sample of 6,798 industrial companies (2019–2020) and 9,304 companies in the service sector (2017–2019) that are part of the directory of the National Administrative Department of Statistics (DANE) in its Technological Innovation and Development Survey (EDIT and EDITS), it can be suggested that the interaction of these two variables (OI and NDAs) generate positive effects for the manufacturing industry but negative ones for the service sector. It could be deduced that the positive effect is due to the greater tradition of OI in the manufacturing industry and the negative effect to the caution that the service sector presents when collaborating with external actors.
MECHANICAL PROPERTIES OF LAMINATED BAMBOO LUMBER MADE OF TROPICAL SPECIES
Authors: Rittironk Supreedee
Published: May 2024

Bamboo has been the trend for a sustainable material, due to its renewability. Bamboo can grow abundantly throughout the tropical area of the world, such as Latin America, East Asia and Southeast Asia. It is seen that Southeast Asia has variety of bamboo to utilize and many of them are suitable for structural applications. One additional reason is that they are clumping type, so fibers are built stronger. Bamboo is hollow and irregular in sizes and shapes, so it cannot maximize the use out of the materials. Bamboo Laminated Lumber (LBL) is the product to solve bamboo issues on the irregularity be transforming into solid lumber. It can be called the engineered bamboo, which have been transformed conventional form of bamboo using engineering process. This is the same technology as laminated timber. It has more potential to substitute the use of timber. This research is to experiment of making LBL using structural bamboo species that are widely used in Southeast Asia. They are Dendrocalamus Asper, Dendrocalamus Sericeus, Bambusa Multiplex, and Bambusa Blumena. They are tested for mechanical properties; Tension, compression parallel to grain, compression perpendicular to grain, and bending. Those properties are compared to other tropical hardwood and engineered wood. The result shows that LBL of all species are qualified for medium-hardwood quality, while B.Multiplex lumber performs best overall. The rest still have great mechanical properties and can be qualified some structural lumber in order to reduce the use of timber.
THE CARBON-REINFORCED CONCRETE BUILDING – CUBE | BOX MANUFACTURING AND ASSEMBLING
Authors: Frenzel Michael
Published: May 2024

The world's first building made entirely of non-metallic reinforcement was constructed in Dresden, Germany in 2022. It will be 220 m² in size and represents the entire process chain of carbon reinforced concrete construction. In Germany's largest construction research project C³-Carbon Concrete Composite, the topic of carbon reinforced concrete and its implementation have been researched and tested since 2014. All the research results were culminated in a lighthouse project, the C³ technology demonstration house CUBE. Based on these results, the boundary conditions for material, form and construction were derived and the necessary structural, experimental and design verifications were provided as well as the approvals for the construction of the building were granted. This paved the way for further new construction projects. Originally planned as an actual cube, architect of HENN Architects gave the CUBE a bit of a twist. And so, an interplay of two essential elements was created: the double-curved striking TWIST shells and the clearly structured BOX. In order to successfully realize the demonstration house CUBE, science and industry combined their competences in carbon reinforced concrete construction. Above all, the BOX precast complex demonstrates the extraordinary and immediate application potential of this composite material. The BOX, described in this paper, consists of semi-precast wall elements and precast slabs that can be manufactured with component thicknesses of just a few centimeters due to the use of carbon reinforcement. Manufacturing technology was tested in an automated precast plant and assembly was implemented at the construction site.
STRAIN MEASUREMENT AND ADHESIVE SELECTION FOR STRAIN GAUGES ON CARBON ROVING IN TEXTILE-REINFORCED CONCRETE STRUCTURES
Authors: Polienko Wladislaw , Tekle Biruk Hailu , Holschemacher Klaus
Published: May 2024

Textile-reinforced concrete (TRC) is a promising building material that meets modern environmental protection and sustainability requirements. For the widespread use of this innovative building material, empirical models based on material properties determined by laboratory tests are needed. This study investigated the ability to measure the strain of carbon rovings with small strain gauges during standard tensile tests. The measured values were compared and validated using the digital image correlation (DIC) method. Another component of this study is the investigation of a suitable adhesive for the application of the sensors to SBR-coated (styrene-butadiene rubber) carbon roving. Three test series with three different adhesives, cyanoacrylate adhesive, epoxy resin, and polychloroprene, were produced and tested for tensile strength. The validation tests showed that a strain loss occurs in the adhesive joint of the strain gauges. It was found that cyanoacrylate adhesives, such as M-Bond 200, suffered the lowest losses and are recommended for further investigations. The epoxy resin influences the stiffness of the carbon fibers at the contact surface too strongly, while the polychloroprene adhesive could not transfer the actual roving strain due to insufficient stiffness of the bond line.
PACKING ORDER THEORY FOR ULTRA-HIGH PERFORMANCE CONCRETE MIX DESIGN: A CRITICAL REVIEW
Authors: Akhnoukh Amin Kamal , Diab Mohamed
Published: May 2024

Ultra-high-performance concrete (UHPC), also known as reactive powder concrete (RPC), is a relatively new construction material with improved mechanical properties and long-term performance. UHPC is manufactured using a specific matrix of well-graded granular particles including Portland cement, supplementary cementitious materials (SCMs), and fine aggregates. The cementitious material matrix is hydrated using a relatively low water-to-powder ratio and high range water reducing chemicals (HRWR). The hydrated mix is augmented with high grade random steel fibers. UHPC superior mechanical performance and durability is attributed to the high packing order of the granular materials within the UHPC mix resulting in lower voids, reduced permeability, and high density. Accordingly, UHPC design depends on proportioning the mix granular material to produce minimal void content (i.e., produce highest packing order). This research paper discusses UHPC mix constituents, proprietary UHPC mix designs, sizes of granular particles, and resulting packing order. Moreover, a critical review of the particles packing order approach used in UHPC mix design is presented. Possible improvement of UHPC mix design may result in economic mixes, enhanced mechanical properties, and increased durability.
OVERVIEW OF STUDIES ON EXTERNAL CONFINEMENT OF R/C COLUMNS USING UNIAXIAL GEOGRID
Authors: Bashir Ruba , Hamad Bilal
Published: May 2024

It has been established in the literature that using uniaxial geogrid as internal confinement for reinforced concrete (R/C) columns would improve the strength and ductility characteristics of the column. However, the potential of using uniaxial geogrid as external confinement remains largely unexplored. The aim of the study is to assess the effectiveness of utilizing uniaxial geogrid as external confinement as compared to FRP external confinement, as well as various configurations of internal confinement, including uniaxial geogrid and stirrups. The assessment encompasses the analysis of axial load-displacement behavior, identification of failure modes, and evaluation of structural ductility through metrics such as fracture energy and energy dissipation. Test results indicate significant benefits associated with external confinement using uniaxial geogrid, including strength, ductility, and energy capacity. This study contributes to the progression of knowledge by illustrating the efficacy of uniaxial geogrid as an external confinement method for reinforced concrete columns. Additionally, it offers valuable comparative insights into different confinement techniques, informing the selection and design of optimal strategies for reinforced concrete structures.
COMPARISON OF SOIL DEFORMATION PARAMETERS DETERMINED BY OEDOMETER AND TRIAXIAL TESTS
Authors: Zakarka Mindaugas , Dirgėlienė Neringa , Skuodis Šarūnas , Fiodorov Michail
Published: May 2024

One of the main parameters characterizing soil deformations is the deformation modulus, which can be determined in the laboratory with an oedometer or a triaxial test device. The authors conducted experimental tests with the oedometer and triaxial test apparatuses with eight different type soils. Experimental data for eight types of sands, clays, silts with specially mixed grain size distribution curves, having different non-plastic fines contents, mean grain sizes and uniformity coefficients, were analyzed. In general, the deformation modulus obtained from the triaxial test is higher than that obtained from the oedometer test, due to the difference in loading conditions. It is important to take into account the specific properties of the soil, like particles form, and test conditions when comparing the values of the deformation modulus obtained by performing different laboratory tests. Also, it is very important to know the magnitude of the loads and the type of foundation when assessing ground deformations.
RHEOLOGICAL CHARACTERIZATION OF TRANSPARENT ASPHALT MODIFIED WITH COLORING PIGMENTS
Authors: Alsuwaidi Alya , Zeiada Waleed , Ashour Ayat , Hamdan Saeed , Ezzat Helal , Al-Khateeb Ghazi G.
Published: May 2024

The black asphalt is high-temperature dependent and viscoelastic in nature, which is prone to experiencing more significant rutting under vehicular loading conditions when exposed to high temperatures. In addition, the pavement temperature contributes towards urban heat island (UHI). Therefore, colored pavement surfaces could play a role in protecting asphalt pavements from excessive rutting. This study investigated the use of transparent asphalt colored with green iron pigment as an alternate asphalt for replacing traditional black asphalt. The paper studied the rheological properties of a transparent asphalt modified with 4% by weight green pigment. The experiment included the determinations of penetration values, softening point temperatures, rotational viscosity, and rutting parameters (G*/sin δ). The AASHTOW Pavement MEPDG Design software was utilized to assess the impact of using transparent and colored asphalt on the simulated rutting performance under Sharjah climate conditions. The study's findings indicated that the transparent and colored asphalt demonstrated superior rheological characteristics compared to black asphalt. The rutting parameter of colored and transparent asphalt was greater than that of the black asphalt. Finally, simulated rutting analysis showed that both transparent and colored asphalt binders exhibited better resistance against long-term rutting performance compared to black asphalt.
A MOBILE-BASED LOCALIZATION SYSTEM FOR INFRASTRUCTURE-INDEPENDENT EMERGENCY COMMUNICATION
Authors: Behrooz Hojat , Ilbeigi Mohammad
Published: May 2024

After natural or human-made disasters, determining the locations of individuals needing urgent assistance is critical and time-sensitive. This paper introduces a novel ad-hoc infrastructure-less communication system for emergency scenarios, relying solely on basic mobile device capabilities. The proposed approach estimates mobile device coordination using multilateration, incorporating path loss theory to transform receiving signal strength into distance. A least square optimization algorithm is also applied to enhance localization accuracy. The system facilitates coordination and communication among citizens and first responders by strategically positioning a few emergency mobile devices as temporary base stations. Mobile devices search for neighboring base stations and transform into temporary base stations upon finding at least four. Those temporary base stations assist farther mobile devices in localization, creating a cascading effect until no more mobile devices are discovered. Simulation demonstrates robustness with a 97% discovery rate, maintaining accuracy even in environmental noise. While promising, real-world validation is essential to assess performance under diverse conditions and practical feasibility.
DEFORMATION OF END CROSSBEAMS OF STEEL BRIDGES RELATED TO SUSTAINABILITY OF BRIDGE JOINTS
Authors: VAN BOGAERT PHILIPPE
Published: May 2024

Both AASHTO and Eurocode stipulate that the deflection of end crossbeams of bridges must be limited to 5 mm under the influence of frequent traffic loads. After a thorough literature review and survey of data from manufacturers of bridge joints, it must be concluded that the background of this requirement is not really based on facts. Durability of bridge joints certainly does not appear to be the basis. Another valid reason can be the comfort of road user, which is effectively disturbed by driving over bumps and thresholds. Although the road user expects light shocks at the end of a bridge, the acceleration inside the vehicle must be limited. Therefore, the state of a wheel driving over a threshold has been studied, by applying analytical equations taken from literature and extended. These allow a fairly accurate simulation of the state. Force required to cross the threshold produces an acceleration of wheel, which is transmitted to vehicle's sprung chassis. In the latter one finds the acceleration to which persons are subjected. Several values of comfort can be considered. It turns out that 5 mm limit is very conservative, and one could easily allow up to double the end cross beam’s deflection.
FATIGUE BOND LIFE OF REINFORCED CONCRETE BEAMS WITH LOW REINFORCEMENT CORROSION
Authors: THAJUDDEEN HALEEMA LAMEEZ , KARTHIK MADHU M
Published: May 2024

Corrosion in reinforced concrete elements can result in a decrease in cross-sectional area and loss of bond between steel and concrete. The cumulative effects of fatigue loading can exacerbate the adverse impact on the bond characteristics between steel and concrete. In this study, the impact of reinforcement corrosion on the fatigue bond life of reinforced concrete members using lap-splice specimens is investigated. The beams are designed such that the failure of the control specimen occurs due to bond failure in the lap-splice region. Stirrups are provided in the lap-splice region to consider the influence of stirrup confinement on bond behavior. The longitudinal rebars and stirrups in the lap-splice region are subject to accelerated corrosion using the impressed current technique, respectively achieving approximately 5% and 15% mass loss. Subsequently, the beam specimens are tested under four-point loading, such that the lap-splice region falls under a constant moment zone. Under monotonic loading, the control specimen experiences abrupt failure due to bond failure. In fatigue loading, the corroded specimen exhibits a significant reduction of 98% in its fatigue life.
DATA-DRIVEN ASSESSMENT OF SHEAR STRENGTH OF SINUSOIDAL CORRUGATED STEEL WEBS
Authors: Alzoubi Rouba , Barakat Samer , Junaid Muhammad Talha
Published: May 2024

The construction industry increasingly recognizes the value of steel beams with corrugated webs for their enhanced resistance to buckling, superior shear capacity, and the elimination of the need for web stiffeners. While a wealth of research focuses on beams with trapezoidal corrugated webs, investigations into sinusoidal corrugated webs (SCWs) remain comparatively sparse. This work investigates the variability in the prediction of the various models and assesses the interactions among different influencing parameters affecting the shear strength of sinusoidal corrugated steel web beams. A comprehensive database of 66 experimental data on SCW beams is assembled and rigorously examined to facilitate this analysis. The collected database is used to test the prediction accuracy of the existing design models provided by codes or proposed models in the literature. The Eurocode3 and DASt-Ri. 015 code models are considered in this study. The results of the evaluated prediction models showed considerable scatters, emphasizing the ongoing need for research to enhance the accuracy of these predictive models for better application in construction practices.
INVESTIGATING FIRE-INDUCED DAMAGE ON FIBER-REINFORCED CONCRETE SAMPLES USING NONDESTRUCTIVE EVALUATION METHODS
Authors: Mpalaskas Anastasios , Kytinou Violetta , Zapris Adamantis , Matikas Theodore
Published: May 2024

This research article investigates the effect of severe thermal exposure on the mechanical behavior of fiber-reinforced concrete specimens. Having been exposed to direct fire, the specimens undergo the fracture experiment to determine their mechanical properties. Fire-damage examination is performed with nondestructive techniques such as acoustic emissions (AE) and ultrasonic pulse velocity (UPV). The main purpose is to demonstrate that AE parameters, such as amplitude, cumulative hits, and energy, have a strong correlation with mechanical parameters and temperature. Besides that, acoustic emission monitoring is also an assessment tool of the structural integrity throughout the entire loading process. The distribution of AE events and the variation of key AE parameters across the load process give very useful hints to differentiate between intact and fired-damaged specimens. The fact that the AE can be used on-site to determine cracks means that it may be used as an alternative method to describe concrete's mechanical properties after fire exposures.
EVALUATING THE PLA AGING EFFECTS ON THE MECHANICAL PERFORMANCE OF 3D-PRINTED COMPONENTS
Authors: Rimkus Arvydas , Šalna Remigijus , Gribniak Viktor
Published: May 2024

The aging influence on the mechanical performance of bio-degradable polymers holds significant importance in additive manufacturing, particularly in structural applications. Understanding the changes in mechanical properties over time is crucial for ensuring the long-term sustainability and reliability of polymer-based structures. Thus, this study aims to comprehensively evaluate the effects of aging on polylactic acid (PLA) by analyzing its failure mechanisms of 3D-printed samples subjected to compression load. To achieve this goal, specimens of PLA were exposed to natural environmental conditions for varying periods. Subsequently, the mechanical characteristics of the additively produced component were assessed after each exposure, providing valuable insights into its performance at different stages of aging. By quantifying the material’s ability to withstand applied forces, the study enables the prediction of its long-term structural integrity. In addition, the investigation of failure mechanisms aids in understanding the modes of failure that PLA may undergo as it ages. This knowledge is essential for developing strategies to prevent structural failures and enhance the overall reliability of PLA-based applications. The findings contribute to advancing the field of additive manufacturing, enabling PLA’s sustainable and reliable application in various industries.
Combined effects of low pressure superheated steam drying and vacuum drying on sugar reduction and quality attribute in mango (Mangifera indica L.) slices
Authors: Liu Jianbo , Xu Xin , Zhang Tianjian , Wang Jingcheng , Wang Ruifang , Xu Qing
Published: May 2024

Consumers paying more attention to physical health has led to an increasing market demand for low-sugar dried fruit products. The quality of products dried via low pressure superheated steam drying (LPSSD) is not only superior to those dried via conventional hot air or vacuum drying (VD), but also has the potential to reduce sugar content. In order to elucidate the mechanism of reducing the sugar of mango slices by LPSSD and obtain low-sugar dried mango slices, the combined effect of LPSSD–VD on mango slices was studied and an evaporation experiment of a sugar solution in a low pressure superheated steam environment was performed. This study revealed that the sugar reduction of mango slices was mainly due to the superheated steam carryover phenomenon in the second half of the constant-temperature stage and the occurrence of Maillard reaction during LPSSD. The quality attributes of mango slices dried using LPSSD–VD was improved compared with LPSSD and VD. As a result, LPSSD–VD could be used to regulate the sugar content in dried fruit and provide a theoretical basis for the production of low-sugar preserved fruits.
Two new Zn(ii) coordination polymers incorporating 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: Synthesis and structure
Authors: Wang Huilin , Wang Xin , Li Meimiao , Feng Jingdong
Published: May 2024

Based on phenanthroline derivate ligand and Zn(ii), two novel coordination polymers, namely [Zn(L)(hta)]
n
(1) and {[Zn2(L)2(dhb)2]·H2O}
n
(2) (L = 2-(2,6-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline, H2hta = heptanedioic acid, and H2dhb = 3,5-dinitro-2-hydroxybenzoic acid), have been synthesized under the hydrothermal condition. For 1, each hta anion bridges two Zn(ii) atoms in a tridentate mode to shape into a chain structure and through different π–π stacking interactions to form a three-dimensional supramolecular structure. The L ligand of 2 connects two neighbouring Zn(ii) atoms to give a 1D chain, which is further extended into the 2D supramolecular layer.
Stress deletion or stress demotion? An acoustic study of stress in Spanish lexical compounds
Authors: Lin Dongmei , Piñeros Carlos-Eduardo
Published: May 2024

In Spanish lexical compounds, stress on the final constituent is consistently preserved; however, it is uncertain whether stress on the initial constituent is preserved as well. Some linguists claim that stress is deleted from the initial constituent, whereas a few argue, instead, that it is demoted from primary to secondary. Given that empirical evidence has been scarce, this issue remains unresolved. To inform the debate, the present study examines all known phonetic correlates of stress in both accented and unaccented contexts. The acoustic measures of lexical compounds are compared to those of non-compound words and phrases that have a similar segmental structure. The results demonstrate that the initial constituent of lexical compounds bears secondary stress. This secondary stress, as a result of stress demotion, differs from rhetorical secondary stress both phonetically and phonologically. These findings provide fresh insights into the definitional properties as well as the prosodic structure of Spanish compounds.
Modelo metodológico de uso de pódcast y vodcast como material académico universitario
Authors: Díaz Monsalvo Miguel Ángel
Published: May 2024

Introducción: La implantación de las Nuevas Tecnologías de la Información y la Comunicación en el ámbito académico ha creado un nuevo paradigma en el proceso de enseñanza-aprendizaje, derivando en las TAC, Tecnologías de Aprendizaje y Conocimiento. Sus cualidades encajan con los preceptos del Espacio Europeo de Educación Superior de promover un aprendizaje autónomo del alumno basado en enfoques innovadores con el empleo de Objetos Virtuales de Aprendizaje (OVA). En estos últimos años ha proliferado el uso de herramientas TAC con elementos sonoros (pódcast) o audiovisuales (vodcast). Metodología: Esta investigación ha buscado en las principales bases de datos de material científico todas las iniciativas docentes generadas en España en los últimos diez años que usan estas herramientas en los Grados de Periodismo, Comunicación Audiovisual y Publicidad mediante una exhaustiva búsqueda de material científico. Resultados: Se han encontrado catorce proyectos que responden a los parámetros de búsqueda y se han sometido a un análisis en profundidad de su desarrollo, objetivos, interrelaciones y puntos fuertes y débiles. Discusión y conclusiones: El análisis aplicado a la revisión del estado de la cuestión ha permitido crear una propuesta metodológica de desarrollo, basada en vincular su finalidad (refuerzo de aprendizaje o simulación de entornos profesionales) con las diferentes áreas competenciales a implementar o desarrollar, tanto en el área instrumental como en las habilidades blandas y trabajo en equipo.
Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway
Authors: Boscher Flore , Jumel Katlyn , Dvorkov Tereza , Gentet Luc J. , Urbain Nadia
Published: May 2024

Rapid eye movement (REM) sleep, also referred to as paradoxical sleep for the striking resemblance of its electroencephalogram (EEG) to the one observed in wakefulness, is characterized by the occurrence of transient events such as limb twitches or facial and rapid eye movements. Here, we investigated the local activity of the primary somatosensory or barrel cortex (S1) in naturally sleeping head-fixed male mice during REM. Through local field potential recordings, we uncovered local appearances of spindle waves in the barrel cortex during REM concomitant with strong delta power, challenging the view of a wakefulness-like activity in REM. We further performed extra- and intracellular recordings of thalamic cells in head-fixed mice. Our data show high-frequency thalamic bursts of spikes and subthreshold spindle oscillations in approximately half of the neurons of the ventral posterior medial nucleus which further confirmed the thalamic origin of local cortical spindles in S1 in REM. Cortical spindle oscillations were suppressed, while thalamus spike firing increased, associated with rapid mouse whisker movements and S1 cortical activity transitioned to an activated state. During REM, the sensory thalamus and barrel cortex therefore alternate between high (wake-like) and low (non-REM sleep-like) activation states, potentially providing a neuronal substrate for mnemonic processes occurring during this paradoxical sleep stage.
Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns
Authors: Yrjölä Pauliina , Vanhatalo Sampsa , Tokariev Anton
Published: May 2024

The third trimester is a critical period for the development of functional networks that support the lifelong neurocognitive performance, yet the emergence of neuronal coupling in these networks is poorly understood. Here, we used longitudinal high-density electroencephalographic recordings from preterm infants during the period from 33 to 45 weeks of conceptional age (CA) to characterize early spatiotemporal patterns in the development of local cortical function and the intrinsic coupling modes [ICMs; phase–phase (PPCs), amplitude–amplitude (AACs), and phase–amplitude correlations (PACs)]. Absolute local power showed a robust increase with CA across the full frequency spectrum, while local PACs showed sleep state-specific, biphasic development that peaked a few weeks before normal birth. AACs and distant PACs decreased globally at nearly all frequencies. In contrast, the PPCs showed frequency- and region-selective development, with an increase of coupling strength with CA between frontal, central, and occipital regions at low-delta and alpha frequencies together with a wider-spread decrease at other frequencies. Our findings together present the spectrally and spatially differential development of the distinct ICMs during the neonatal period and provide their developmental templates for future basic and clinical research.
The role of the tumor microenvironment in papillary thyroid microcarcinoma nodal metastasis
Authors: Kim Mijin , Kwon Chae Hwa , Kim Bo Hyun
Published: May 2024

The genetic alterations currently identified in papillary thyroid microcarcinomas (PTMCs) are insufficient for distinguishing tumors with aggressive features. We aimed to identify candidate markers associated with lateral lymph node metastasis (LLNM, N1sb disease) in patients with PTMC using transcriptomic analysis. RNA sequencing was performed on 26 matched tumor and normal thyroid tissue samples (N0, n = 14; N1b, n = 12), followed by functional enrichment analyses of differentially expressed genes (DEGs). EcoTyper was used to explore the distinct tumor microenvironment (TME). We identified 631 DEGs (213 upregulated and 418 downregulated) between N1b and N0 PTMCs. The most significantly upregulated genes in N1b were associated with tumorigenesis, adhesion, migration, and invasion. DEGs were mainly enriched in the pathways of idiopathic pulmonary fibrosis, TME, wound healing, and inhibition of matrix metalloproteases. We predicted the activation of these pathways in N1b PTMCs. N1b PTMCs had a unique TME with abundant fibroblasts and epithelial cells, associated with an increased risk of disease progression. Fibroblast marker genes, including POSTN, MMP11, TNFAIP6,and FN1, and epithelial cell marker genes, including NOX4, MFAP2, TGFVBI,and TNC, were selected. POSTN and FN1, fibroblast cell-specific genes, and NOX4 and TNC, epithelial cell-specific genes, were promising biomarkers for predicting LLNM development and recurrence in patients with PTMC. We delineated the cellular ecotypes within the TME of patients with N1b PTMC and revealed potential markers for predicting LLNM and the prognosis of PTMC. These findings provide valuable insights into the contributions of cancer-associated fibroblasts and epithelial cells to PTMC progression and metastasis.
The Influence of Polarized Phonons on Interband Light Absorption in Spheroidal Quantum Dots of the CdS/SiO2 Heterosystem
Authors: Holskyi V.B. , Leshko R.Ya. , Brytan V.B. , Uhryn Y.O. , Karpiy V.R.
Published: May 2024

The influence of confined phonons on the coefficient of interband absorption of polarized light as a function of its frequency has been investigated. A comparison was made between the obtained results and those obtained considering polarized phonons in a bulk crystal. The dependence of interband light absorption on the ellipsoid's axis ratio has been established. Calculations were performed for various temperatures and radii of the quantum dot in the CdS/SiO2 heterostructure, shaped as an elongated spheroid.
KİRA UYUŞMAZLIKLARINDA DAVA ŞARTI ARABULUCULUK VE TİCARİ DAVA ŞARTI ARABULUCULUK ÜZERİNDEKİ ETKİLERİ
Authors: Çelik Aytekin , Doğu Hakkı Mert
Published: May 2024

Hukuk Uyuşmazlıklarında Arabuluculuk Kanunu’na eklenen 18/B maddesiyle kiralanan taşınmazların ilamsız icra yoluyla tahliyesi dışında kalan kira uyuşmazlıklarında dava açılmadan önce arabulucuya başvurulması dava şartı olarak kabul edilmiştir. Söz konusu düzenleme hem taşınır hem de taşınmazlara ilişkin kira uyuşmazlıklarını kapsamaktadır ve her türlü kira uyuşmazlığında gündeme gelmektedir.
Türk Ticaret Kanunu m. 5/A çerçevesinde her iki tarafın ticari işletmesini ilgilendiren kira sözleşmelerinden konusu bir miktar para olan alacak, tazminat, menfi tespit, itirazın iptali ve istirdat davalarında arabulucuya başvurulması dava şartıdır. Hukuk Uyuşmazlıklarında Arabuluculuk Kanunu m. 18/B ile söz konusu uyuşmazlıklarla beraber bu kapsama girmeyen diğer kira uyuşmazlıkları da dava şartı arabuluculuk kapsamına dahil edilmiştir. Çalışmada her iki tarafın ticari işletmesini ilgilendiren kira sözleşmesine ilişkin uyuşmazlıklarda dava şartı arabuluculuk konusu da ele alınmıştır.
Immediate prepectoral implant-based breast reconstruction for breast cancer patients
Authors:   , Ostapenko Edvin
Published: May 2024

The aim of this dissertation was to provide the evidence for the oncological safety, to evaluate results of combined treatment and quality of life, and to optimize surgical technique in NSM following immediate prepectoral IBBR for BC patients. The dissertation consists of an introduction, literature review, methods, results, discussion, conclusions, reference list, summary, and author's publications. Performed scientific research confirm the thesis that variations in surgical approaches did not affect oncologic outcomes in immediate prepectoral IBBR. Data revealed that the IMF technique is a preferable method for cup A-B sized breasts with ptosis grade 0-I in BC patients after immediate prepectoral IBBR. The inverted-T technique is a preferable method for cup C-D sized breasts with ptosis grade II-III in BC patients after immediate prepectoral IBBR. The dissertation results showed that patients in the PMRT group had statistically higher rates of implant loss and capsular contracture, than non-irradiated patients regardless of the surgical approach in immediate prepectoral IBBR.
Atsparumo 5-fluoruracilui ir oksaliplatinai molekulinių mechanizmų tyrimai žmogaus kolorektalinės karcinomos ląstelėse
Authors:   , Žitkutė Vilmantė
Published: May 2024

The analysis of the molecular mechanisms of resistance to 5-fluorouracil and oxaliplatin in human colorectal carcinoma cells
Reljefą sudarančio vidurinio pleistoceno moreninio smulkaus grunto savybių įvertinimas
Authors:   , Lekstutytė Ieva
Published: May 2024

Assessment of Middle Pleistocene terrain forming fine-grained till soil properties
Ma’had Aly Lecturers’ Research and Publication Activities: Challenges and Prospects
Authors: Purnomo Pungki , Wenny Lili Sudria , Farida Ida , Hamdani Fadhilatul
Published: May 2024

PurposeIn Islamic higher education, Ma'had Aly lecturers rarely performed research and publication activities. The study aimed to explore Ma’had Aly lecturers’ in conducting research and publishing scholarly works activities.MethodThis qualitative study used a case study design whose data collection techniques utilized in-depth interviews and a review of relevant articles. The informants comprised four Ma'had Aly lecturers taken purposively.Results/findingsThe findings revealed problems that caused lecturer Ma'had Aly to rarely carry out research and publication activities. In terms of personnel problems, apart from the fact that Ma'had Aly lecturers had not only adequate knowledge regarding research and publications, but they were also burdened with a heavy teaching load and other non-academic activities. Meanwhile, in terms of institutional problems, Ma'had Aly could not create a conducive atmosphere for lecturers to perform research and publication activities.Conclusion Research and publication are important for Ma'had Aly lecturers for their professional development. Therefore, both Ma'had Aly management and the Ministry of Religion should make various efforts to accelerate the research and publication competency improvement of Ma'had Aly lecturers.
Translation Equivalence Degrees among Indonesian EFL Undergraduate Students
Authors: Baihaqi Akhmad
Published: May 2024

PurposeThe way to produce an equivalent translation text appears hard that every translation work should engage with diverse language and cultural systems. The issues are expected to affect both translation students and professional translators. Therefore, this current work aims to discover in-depth information about translation equivalence degrees among Indonesian EFL undergraduate students.MethodThis study employed qualitative content analysis. The research data included documentation of the translation texts from English into the Indonesian language, which resulted in 22 students majoring in English education at a public university in Banten Province, Indonesia. The source language texts were derived from the news-item texts published in national newspapers. The data analysis procedure comprised comparing the two texts, classifying, discussing, drawing conclusions, and making interpretations. Results/findingsThe study of the translation texts revealed that 11 texts (50%) referred to near-optimal translation, six texts (27%) to partial translation, and five texts (23%) to poor translation.ConclusionGiven that none of the students' translation outputs achieved the optimal equivalency; this conclusion suggests that students' translation knowledge and skills still need to be improved by regular practice and discussion at each translation course meeting.
A Comparative Study of Students Graduation Analysis Using Classification Methods in Undergraduate Electrical Engineering Tidar University
Authors: Wicaksono Damar , Nisworo Sapto , Nata Imam Adi
Published: May 2024

This research aimed to classify achievement factors for electrical engineering students at Tidar University using K-Means and Agglomerative Clustering classification algorithms. The goal was to understand if any parameters influence high-achieving student performance. The Indonesian government and private sector for university students provide significant education funds. Student scholarships are awarded based primarily on GPA and entry path, overburdening staff and causing confusion during distribution to eligible recipients. A system was needed to accommodate additional eligible criteria. The researcher selected factors to identify engineering student performance, including school origin, entry path, tuition fees, and GPA. These inputs could determine graduation status. The results compared calculation methods based on collected data accuracy, processing times, and characterizing clustered data to determine the best classification method. Agglomerative Hierarchical Clustering performed better. Accuracy testing on 600 training data points yielded 73.94% for improved K-means and 90.42% for AHC. The Average processing time was 674.92 seconds for improved K-means and 554.35 seconds for AHC. Silhouette testing also characterized calculation methods, with improved K-means scoring best at 0.654 and AHC at 0.787 using two clusters.
SVM Optimization with Grid Search Cross Validation for Improving Accuracy of Schizophrenia Classification Based on EEG Signal
Authors: Desiawan Masdar , Solichin Achmad
Published: May 2024

The advantage of the Support Vector Machine (SVM) is that it can solve classification and regression problems both linearly and non-linearly. SVM also has high accuracy and a relatively low error rate. However, SVM also has weaknesses, namely the difficulty of determining optimal parameter values, even though setting exact parameter values affects the accuracy of SVM classification. Therefore, to overcome the weaknesses of SVM, optimizing and finding optimal parameter values is necessary. The aim of this research is SVM optimization to find optimal parameter values using the Grid Search Cross-Validation method to increase accuracy in schizophrenia classification. Experiments show that optimization parameters always find a nearly optimal combination of parameters within a specific range. The results of this study show that the level of accuracy obtained by SVM with the grid search cross-validation method in the schizophrenia classification increased by 9.5% with the best parameters, namely C = 1000, gamma = scale, and kernel = RBF, the best parameters were applied to the SVM algorithm and obtained an accuracy of 99.75%, previously without optimizing the accuracy reached 90.25%. The optimal parameters of the SVM obtained by the grid search cross-validation method with a high degree of accuracy can be used as a model to overcome the classification of schizophrenia.
A Comparative Analysis of Random Forest, XGBoost, and LightGBM Algorithms for Emotion Classification in Reddit Comments
Authors: Anggraini Nenny , Putra Syopiansyah Jaya , Wardhani Luh Kesuma , Arif Farid Dhiya Ul , Hakiem Nashrul , Shofi Imam Marzuki
Published: May 2024

This research aims to compare the performance of three classification algorithms, namely Random Forest, XGBoost, and LightGBM, in classifying emotions in Reddit comments. Emotion classification in Reddit comments is a complex classification problem due to its numerous variations and ambiguities. This research utilizes the GoEmotions Fine-Grained dataset, filtered down to 7,325 Reddit comments with 5 different basic emotion labels. In this study, data preprocessing steps, feature extraction using CountVectorizer and TF-IDF, and hyperparameter tuning using GridSearchCV for each algorithm are conducted. Subsequently, model evaluation is performed using Cross-Validation and confusion matrix. The results of the study indicate that Random Forest outperforms the XGBoost and LightGBM algorithm with an accuracy of 75.38% compared to XGBoost with 69.05% accuracy and LightGBM with 66.63% accuracy.