bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic Accuracy of Radiologic Methods for Ankle Syndesmosis Injury: A Systematic Review and Meta-Analysis
Authors: Chun Dong-il , Cho Jae-ho , Min Tae-Hong , Yi Young , Park Su Yeon , Kim Kwang-Hyun , Kim Jae Heon , Won Sung Hun
Published: July 2019

Misdiagnosis and inadequate treatment of syndesmosis could result in significant long-term morbidity including pain, instability, and degenerative changes of the ankle joint. The objective of this systematic review and meta-analysis was to determine whether radiologic tests accurately and reliably diagnose ankle syndesmosis injury. Medline, Embase, and Cochrane were searched. The database search resulted in 258 full text articles that we assessed for eligibility, we used eight studies that met all the inclusion criteria. In subgroup meta-analysis, the sensitivity analysis showed significant differences only in the MRI (Magnetic Resonance Imaging), and specificity was not statistically significant. In diagnostic meta-analysis, the pooled sensitivity and specificity were 0.528 and 0.984 for X-rays, 0.669 and 0.87 for CT (Computed Tomography), and 0.929 and 0.865 for MRI, all respectively. For sensitivity, MRI showed significantly sensitivity as higher than the other methods, and we detected no significance for specificity. Syndesmosis injuries differed significantly in the accuracy of radiological methods according to the presence of accompanied ankle fractures. In patients with fractures, simple radiography has good specificity, and CT and MRI have high sensitivity and specificity irrespective of fracture; in particular, MRI has similar accuracy to gold standard arthroscopic findings.
Twin-Twin Transfusion Syndrome with and without Selective Fetal Growth Restriction Prior to Fetoscopic Laser Surgery: Short and Long-Term Outcome
Authors: Groene Sophie G. , Tollenaar Lisanne S. A. , van Klink Jeanine M. M. , Haak Monique C. , Klumper Frans J. C. M. , Middeldorp Johanna M. , Oepkes Dick , Slaghekke Femke , Lopriore Enrico
Published: July 2019

As twin-twin transfusion syndrome (TTTS) and selective fetal growth restriction (sFGR) are both prevalent complications of monochorionic (MC) twin pregnancies, its coexistence is not uncommon. The aim of this study is to evaluate the short and long-term outcome in TTTS with and without sFGR prior to fetoscopic laser coagulation. All TTTS cases treated with laser surgery at our center between 2001–2019 were retrospectively reviewed for the presence of sFGR, defined as an estimated fetal weight (EFW) <10th centile. We compared two groups: TTTS-only and TTTS + sFGR. Primary outcomes were perinatal survival and long-term severe neurodevelopmental impairment (NDI). Of the 527 pregnancies eligible for analysis, 40.8% (n = 215) were categorized as TTTS-only and 59.2% (n = 312) as TTTS + sFGR. Quintero stage at presentation was higher in the TTTS + sFGR group compared to the TTTS-only group (57% compared to 44% stage III). Separate analysis of donors showed significantly lower perinatal survival for donors in the TTTS + sFGR group (72% (224/311) compared to 81% (173/215), p = 0.027). Severe NDI at follow-up in long-term survivors in the TTTS-only and TTTS + sFGR group was present in 7% (13/198) and 9% (27/299), respectively (p = 0.385). Both sFGR (OR 1.5;95% CI 1.1–2.0, p = 0.013) and lower gestational age at laser (OR 1.1;95% CI 1.0–1.1, p = 0.001) were independently associated with decreased perinatal survival. Thus, sFGR prior to laser surgery is associated with a more severe initial presentation and decreased donor perinatal survival. The long-term outcome was not affected.
Influence of Body Composition on Arterial Stiffness in Middle-Aged Adults: Healthy UAL Cross-Sectional Study
Authors: Hernandez-Martinez Alba , Martinez-Rosales Elena , Alcaraz-Ibañez Manuel , Soriano-Maldonado Alberto , Artero Enrique G.
Published: July 2019

Background and objectives: Several anthropometric and body composition parameters have been linked to arterial stiffness (AS) as a biomarker of cardiovascular disease. However, little is known about which of these closely related factors is more strongly associated with AS. The aim of the present study was to analyze the relationship of different anthropometric and body composition parameters with AS in middle-aged adults. Materials and Methods: This cross-sectional study included 186 middle-aged participants (85 women, 101 men; age = 42.8 ± 12.6 years) evaluated as part of the Healthy UAL study, a population study conducted at the University of Almería with the main purpose of analyzing the etiology and risk factors associated with cardio-metabolic diseases. Anthropometric measures included neck, waist, and hip circumferences, as well as the waist-to-height ratio (WHtr). Bioimpedance-derived parameters included fat-free mass index (FFMI), fat mass index (FMI), and percent of body fat (%BF). AS was measured by pulse wave velocity (PWV). The relationships of interest were examined through stepwise regression analyses in which age and sex were also introduced as potential confounders. Results: Neck circumference (in the anthropometric model; R2: 0.889; β: age = 0.855, neck = 0.204) and FFMI (in the bio-impedance model; R2: 0.891; β: age = 0.906, FFMI = 0.199) emerged as significant cross-sectional predictors of AS. When all parameters were included together (both anthropometry and bio-impedance), both neck circumference and FFMI appeared again as being significantly associated with AS (R2: 0.894; β: age = 0.882, FFMI = 0.126, neck = 0.093). Conclusion: It was concluded that FFMI and neck circumference are correlated with AS regardless of potential confounders and other anthropometric and bioimpedance-derived parameters in middle-aged adults.
Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
Authors: Tsurumaki Hiroaki , Matsuyama Toshiyuki , Ezawa Kazuma , Koga Yasuhiko , Yatomi Masakiyo , Aoki-Saito Haruka , Chikamatsu Kazuaki , Hisada Takeshi
Published: July 2019

A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia.
Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review
Authors: Rondanelli Mariangela , Faliva Milena A. , Gasparri Clara , Peroni Gabriella , Naso Maurizio , Picciotto Giulia , Riva Antonella , Nichetti Mara , Infantino Vittoria , Alalwan Tariq A. , Perna Simone
Published: July 2019

Background and objective: Often micronutrient deficiencies cannot be detected when patient is already following a long-term gluten-free diet with good compliance (LTGFDWGC). The aim of this narrative review is to evaluate the most recent literature that considers blood micronutrient deficiencies in LTGFDWGC subjects, in order to prepare dietary supplementation advice (DSA). Materials and methods: A research strategy was planned on PubMed by defining the following keywords: celiac disease, vitamin B12, iron, folic acid, and vitamin D. Results: This review included 73 studies. The few studies on micronutrient circulating levels in long-term gluten-free diet (LTGFD) patients over 2 years with good compliance demonstrated that deficiency was detected in up to: 30% of subjects for vitamin B12 (DSA: 1000 mcg/day until level is normal, then 500 mcg), 40% for iron (325 mg/day), 20% for folic acid (1 mg/day for 3 months, followed by 400–800 mcg/day), 25% for vitamin D (1000 UI/day or more-based serum level or 50,000 UI/week if level is <20 ng/mL), 40% for zinc (25–40 mg/day), 3.6% of children for calcium (1000–1500 mg/day), 20% for magnesium (200–300 mg/day); no data is available in adults for magnesium. Conclusions: If integration with diet is not enough, starting with supplements may be the correct way, after evaluating the initial blood level to determine the right dosage of supplementation.
Numerical Simulation for FSW Process at Welding Aluminium Alloy AA6082-T6
Authors: Sibalic Nikola , Vukcevic Milan
Published: July 2019

This paper presents the numerical simulation of the Friction stir welding (FSW) process obtained by using the DEFORM 3D software package. Numerical simulations are based on experimental research, welding of aluminum alloy AA6082-T6 by FSW method, which has the thickness of 7.8 mm. The aim of this paper is to determine the reliability of numerical simulations in the FSW process, which is followed by large deformations, where influential geometric and kinematic parameters are varied. Numerical research was done on the basis of the adopted five-phase orthogonal experimental plan with a variety of factors on two levels and repetition at the central point of the plan for four times. The parameters varied in the experiment are: Welding speed v mm/min, a rotation speed of tool ω rpm, angle of pin slopes α o, a diameter of the pin d mm, diameter of the shoulder D mm. During the performing of the FSW process, forces were measured in three normal directions: Axial force Fz, longitudinal force Fx and side force Fy, as well as the temperature in the adopted measuring positions of the workpiece. The experimental results obtained in this way were compared with the numerical experiment in the same adopted measuring positions, i.e., in the paper an analysis and comparison of the obtained experimental and numerical data of the measured forces and the generated temperature field were made.
Eicosanoid Profile of Influenza A Virus Infected Pigs
Authors: Schultz Daniel , Methling Karen ,   KoInfekt Study Group, Rothe Michael , Lalk Michael
Published: July 2019

Respiratory tract infections caused by the Influenza A virus (IAV) are a worldwide problem for human and animal health. Within this study, we analyzed the impact of IAV infection on the immune-related lipidome (eicosanoids) of the pig as new infection model. For this purpose, we performed HPLC-MS/MS using dynamic multiple reaction monitoring and analyzed lung, spleen, blood plasma and bronchoalveolar lavages. IAV infection leads to collective changes in the levels of the analyzed hydroxyeicosatrienoic acids (HETEs), hydroxydocosahexaenoic acids (HDHAs) and epoxyeicosatrienoic acids (EETs), and moreover, unique eicosanoid changes in several sample types, even under mild infection conditions. In accordance with different mouse infection studies, we observed infection-related patterns for 12-HETE, 15-HETE and 17-HDHA, which seem to be common for IAV infection. Using a long-term approach of 21 days we established an experimental setup that can be used also for bacterial-viral coinfection experiments.
Effects of Water Availability in the Soil on Tropane Alkaloid Production in Cultivated Datura stramonium
Authors: Moreno-Pedraza Abigail , Gabriel Jennifer , Treutler Hendrik , Winkler Robert , Vergara Fredd
Published: July 2019

Background: different Solanaceae and Erythroxylaceae species produce tropane alkaloids. These alkaloids are the starting material in the production of different pharmaceuticals. The commercial demand for tropane alkaloids is covered by extracting them from cultivated plants. Datura stramonium is cultivated under greenhouse conditions as a source of tropane alkaloids. Here we investigate the effect of different levels of water availability in the soil on the production of tropane alkaloids by D. stramonium. Methods: We tested four irrigation levels on the accumulation of tropane alkaloids. We analyzed the profile of tropane alkaloids using an untargeted liquid chromatography/mass spectrometry method. Results: Using a combination of informatics and manual interpretation of mass spectra, we generated several structure hypotheses for signals in D. stramonium extracts that we assign as putative tropane alkaloids. Quantitation of mass spectrometry signals for our structure hypotheses across different anatomical organs allowed us to identify patterns of tropane alkaloids associated with different levels of irrigation. Furthermore, we identified anatomic partitioning of tropane alkaloid isomers with pharmaceutical applications. Conclusions: Our results show that soil water availability is an effective method for maximizing the production of specific tropane alkaloids for industrial applications.
Antioxidant and Lipoxygenase Inhibitory Activities of Essential Oils from Endemic Plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum Ake Assi and Zanthoxylum psammophilum Ake Assi
Authors: Tanoh Evelyne A. , Nea Fatimata , Kenne Kemene Tierry , Genva Manon , Saive Matthew , Tonzibo Felix Z. , Fauconnier Marie-Laure
Published: July 2019

Zanthoxylum mezoneurispinosum Ake Assi and Zanthoxylum psammophilum Ake Assi are species endemic to Côte d’Ivoire. In this study, we determined, for the first time, the composition and biological activities of essential oils obtained from each of these plants. Essential oils were obtained by hydrodistillation from different organs of each plant with a Clevenger-type apparatus and analyzed by gas chromatography–mass spectrometry (GC-MS). Thirty-four components, accounting for more than 99.9% of the overall composition, were identified in the oils. The Z. psammophilum leaf and trunk bark oils exhibited two unusual methylketones, undecan-2-one and tridecan-2-one, whereas the root oil was rich in thymol and sesquiterpenoids. The Z. mezoneurispinosum leaf and trunk bark oils were rich in monoterpenoids, whereas sesquiterpenoids were predominant in the root oil. These samples produced, for the first time, some new chemical profiles of essential oils. The oils’ antioxidant activities were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity and ferric reducing antioxidant power (FRAP) assays. The results showed that the essential oil isolated from roots of Z. mezoneurispinosum had the highest antioxidant activity, which is in accordance with the high thymol content of that oil. We also determined the lipoxygenase inhibitory activities of the essential oils. The results showed that all of the tested oils displayed high and close lipoxygenase inhibitory activities.
New HSV-1 Anti-Viral 1′-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety
Authors: Tănase Constantin I. , Drăghici Constantin , Hanganu Anamaria , Pintilie Lucia , Maganu Maria , Volobueva Alexandrina , Sinegubova Ekaterina , Zarubaev Vladimir V. , Neyts Johan , Jochmans Dirk , Slita Alexander V.
Published: July 2019

New 1′-homocarbanucleoside analogs with an optically active substituted bicyclo[2.2.1]heptane skeleton as sugar moiety were synthesized. The pyrimidine analogs with uracil, 5-fluorouracil, thymine and cytosine and key intermediate with 6-chloropurine (5) as nucleobases were synthesized by a selective Mitsunobu reaction on the primary hydroxymethyl group in the presence of 5-endo-hydroxyl group. Adenine and 6-substituted adenine homonucleosides were obtained by the substitution of the 6-chlorine atom of the key intermediate 5 with ammonia and selected amines, and 6-methoxy- and 6-ethoxy substituted purine homonucleosides by reaction with the corresponding alkoxides. No derivatives appeared active against entero, yellow fever, chikungunya, and adeno type 1viruses. Two compounds (6j and 6d) had lower IC50 (15 ± 2 and 21 ± 4 µM) and compound 6f had an identical value of IC50 (28 ± 4 µM) to that of acyclovir, suggesting that the bicyclo[2.2.1]heptane skeleton could be further studied to find a candidate for sugar moiety of the nucleosides.
Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions
Authors: Mostarda Serena , Gür Maz Tugçe , Piccinno Alessandro , Cerra Bruno , Banoglu Erden
Published: July 2019

A novel flow-based approach for the preparation of benzimidazol-2-one (1) scaffold by the 1,1′-carbonyldiimidazole (CDI)-promoted cyclocarbonylation of o-phenylenediamine (2) is reported. Starting from a preliminary batch screening, the model reaction was successfully translated under flow conditions and optimised by means of design of experiment (DoE). The method allowed the efficient preparation of this privileged scaffold and to set up a general protocol for the multigram-scale preparation in high yield, purity, and productivity, and was successfully applied for the multigram flow synthesis of N-(2-chlorobenzyl)-5-cyano-benzimidazol-2-one, which is a key synthon for hit-to-lead explorations in our anti-inflammatory drug discovery program.
A Primer on Quality Assurance and Performance Improvement for Interprofessional Chronic Kidney Disease Care: A Path to Joint Commission Certification
Authors: Awdishu Linda , Moore Teri , Morrison Michelle , Turner Christy , Trzebinska Danuta
Published: July 2019

Interprofessional care for chronic kidney disease facilitates the delivery of high quality, comprehensive care to a complex, at-risk population. Interprofessional care is resource intensive and requires a value proposition. Joint Commission certification is a voluntary process that improves patient outcomes, provides external validity to hospital administration and enhances visibility to patients and referring providers. This is a single-center, retrospective study describing quality assurance and performance improvement in chronic kidney disease, Joint Commission certification and quality outcomes. A total of 440 patients were included in the analysis. Thirteen quality indicators consisting of clinical and process of care indicators were developed and measured for a period of two years from 2009–2017. Significant improvements or at least persistently high performance were noted for key quality indicators such as blood pressure control (85%), estimation of cardiovascular risk (100%), measurement of hemoglobin A1c (98%), vaccination (93%), referrals for vascular access and transplantation (100%), placement of permanent dialysis access (61%), discussion of advanced directives (94%), online patient education (71%) and completion of office visit documentation (100%). High patient satisfaction scores (94–96%) are consistent with excellent quality of care provided.
A Computational Fluid Dynamics Approach for the Modeling of Gas Separation in Membrane Modules
Authors: Qadir Salman , Hussain Arshad , Ahsan Muhammad
Published: July 2019

Natural gas demand has increased rapidly across the globe in the last decade, and it is set to play an important role in meeting future energy requirements. Natural gas is mainly produced from fossil fuel and is a side product of crude oil produced beneath the earth’s crust. Materials hazardous to the environment, like CO2, H2S, and C2H4, are present in raw natural gas. Therefore, purification of the gaseous mixture is required for use in different industrial applications. A comprehensive computational fluid dynamics (CFD) model was proposed to perform the separation of natural gas from other gases using membrane modules. The CFD technique was utilized to estimate gas flow variations in membrane modules for gas separation. CFD was applied to different membrane modules to study gas transport through the membrane and flux, and to separate the binary gas mixtures. The different parameters of membrane modules, like feed and permeate pressure, module length, and membrane thickness, have been investigated successfully. CFD allows changing the specifications of membrane modules to better configure the simulation results. It was concluded that in a membrane module with increasing feed pressure, the pressure gradient also increased, which resulted in higher flux, higher permeation, and maximum purity of the permeate. Due to the high purity of the gaseous product in the permeate, the concentration polarization effect was determined to be negligible. The results obtained from the proposed CFD approach were verified by comparing with the values available in the literature.
A LIDAR-Compatible, Multichannel Raman Spectrometer for Remote Sensing of Water Temperature
Authors: de Lima Ribeiro Andréa , Artlett Christopher , Pask Helen
Published: July 2019

The design and operation of a custom-built LIDAR-compatible, four-channel Raman spectrometer integrated to a 532 nm pulsed laser is presented. The multichannel design allowed for simultaneous collection of Raman photons at two spectral regions identified as highly sensitive to changes in water temperature. For each of these spectral bands, the signals having polarization parallel to (∥) and perpendicular to (⟂), the excitation polarization were collected. Four independent temperature markers were calculated from the Raman signals: two-colour(∥), two-colour(⟂), depolarization(A) and depolarization(B). A total of sixteen datasets were analysed for one ultrapure (Milli-Q) and three samples of natural water. Temperature accuracies of ±0.4 °C–±0.8 °C were achieved using the two-colour(∥) marker. When multiple linear regression models were constructed (linear combination) utilizing all simultaneously acquired temperature markers, improved accuracies of ±0.3 °C–±0.7 °C were achieved.
Home Energy Management System Incorporating Heat Pump Using Real Measured Data
Authors: Cao Zhengnan , O’Rourke Fergal , Lyons William , Han Xiaoqing
Published: July 2019

The demand for electricity has been rising significantly over the past years and it is expected to rise further in the coming years due to economic and societal development. Smart grid technology is being developed in order to meet the rising electricity requirement. In order for the smart grid to perform its full functions, the Energy Management Systems (EMSs), especially Home Energy Management Systems (HEMS) are essential. It is necessary to understand the energy demand of the loads and the energy supply either from the national grid or from renewable energy technologies. To facilitate the Demand Side Management (DSM), Heat Pumps (HP) and air conditioning systems are often utilised for heating and cooling in residential houses due to their high-efficiency power output and low CO2 emissions. This paper presents a program for a HEMS using a Particle Swarm Optimisation (PSO) algorithm. A HP is used as the load and the aim of the optimisation program is to minimise the operational cost, i.e., the cost of electricity, while maintaining end-user comfort levels. This paper also details an indoor thermal model for temperature update in the heat pump control program. Real measured data from the UK Government’s Renewable Heat Premium Payment (RHPP) scheme was utilised to generate characteristic curves and equations that can represent the data. This paper compares different PSO variants with standard PSO and the unscheduled case calculated from the data for five winter days in 2019. Among all chosen algorithms, the Crossover Subswarm PSO (CSPSO) achieved an average saving of 25.61% compared with the cost calculated from the measured data with a short search time of 1576 ms for each subswarm. It is clear from this work that there is significant scope to reduce the cost of operating a HP while maintaining end user comfort levels.
Ranking of Normality Tests: An Appraisal through Skewed Alternative Space
Authors: Islam Tanweer Ul
Published: July 2019

In social and health sciences, many statistical procedures and estimation techniques rely on the underlying distributional assumption of normality of the data. Non-normality may lead to incorrect statistical inferences. This study evaluates the performance of selected normality tests within the stringency framework for skewed alternative space. The stringency concept allows us to rank the tests uniquely. The Bonett and Seier test (Tw) turns out to represent the best statistics for slightly skewed alternatives and the Anderson–Darling (AD); Chen–Shapiro (CS); Shapiro–Wilk (W); and Bispo, Marques, and Pestana (BCMR) statistics are the best choices for moderately skewed alternative distributions. The maximum loss of Jarque–Bera (JB) and its robust form (RJB), in terms of deviations from the power envelope, is greater than 50%, even for large sample sizes, which makes them less attractive in testing the hypothesis of normality against the moderately skewed alternatives. On balance, all selected normality tests except Tw and Daniele Coin’s COIN-test performed exceptionally well against the highly skewed alternative space.
Effectiveness of Autologous Fat Graft in Treating Fecal Incontinence
Authors: Jeong Hyeonseok , Hwang Sung Hwan , Kim Hyoung Rae , Ryu Kil O , Lim Jiyong , Yu Hye Mi , Yoon Jihoon , Kim Chee Young , Jeong Kwang-Yong , Jung Young Jae , Jeong In Seob , Choi Young Gil
Published: July 2019

Purpose: The most common risk factor for fecal incontinence (FI) is obstetric injury. FI affects 1.4%–18% of adults. Most patients are unaware when they are young, when symptoms appear suddenly and worsen with aging. Autologous fat graft is widely used in cosmetic surgical field and may substitute for injectable bulky agents in treating FI. Authors have done fat graft for past several years. This article reports the effectiveness of the fat graft in treating FI and discusses satisfaction with the procedure.Methods: Fat was harvested from both lateral thighs using 10-mL Luer-loc syringe. Pure fat was extracted from harvests and mixed with fat, oil, and tumescent through refinement. Fats were injected into upper border of posterior ano-rectal ring, submucosa of anal canal and intersphincteric space. Thirty-five patients with FI were treated with this method from July 2016 to February 2017 in Busan Hangun Hospital. They were 13 male (mean age, 60.8 years) and 22 female patients (mean age, 63.3 years). The Wexner score was checked before procedure. We evaluated outcome in outpatients by asking the patients. For 19 patients we checked the Wexner score after procedure.Results: Symptom improved in 29 (82.9%), and not improved in 6 (17.1%). In 2 of 6 patients, they felt better than before procedure, although not satisfied. No improvement in 4. Mean Wexner score was 9.7 before procedure. There were no serious complications such as inflammation or fat embolism.Conclusion: Autologous fat graft can be an effective alternative treatment for FI. It is safe and easy to perform, and cost effective.
Oncologic Outcomes of Postoperative Chemoradiotherapy Versus Chemotherapy Alone in Stage II and III Upper Rectal Cancer
Authors: Yoon Ji Eun , Lee Soo Young , Kwak Han Duk , Yeom Seung Seop , Kim Chang Hyun , Joo Jae Kyun , Kim Hyeong Rok , Kim Young Jin
Published: July 2019

Purpose: The aim of this study was to assess oncological outcomes of postoperative radiotherapy plus chemotherapy (CRT) versus chemotherapy alone (CTx) in stage II or III upper rectal cancer patients who underwent curative surgery.Methods: We retrospectively reviewed 263 consecutive patients with pathologic stage II or III upper rectal cancer who underwent primary curative resection with postoperative CRT or CTx from January 2008 to December 2014 at Chonnam National University Hwasun Hospital. Multivariate and propensity score matching analyses were used to reduce selection bias.Results: Median follow-up was 48.1 months for the entire cohort and 53.5 months for the matched cohort. In subgroup analysis of the propensity score matched cohort, the 3-year local recurrence-free survival was 94.1% (95% confidence interval [CI], 87.8%–100%) in the CRT group and 90.1% (95% CI, 82.8%–97.9%) in the CTx group (P = 0.370). No significant difference in disease-free survival was observed according to treatment type. On multivariate analysis, circumferential resection margin involvement (hazard ratio [HR], 2.386; 95% CI, 1.190–7.599; P = 0.032), N stage (HR, 6.262; 95% CI, 1.843–21.278, P = 0.003), and T stage (HR, 5.896, 95% CI, 1.298–6.780, P = 0.021) were identified as independent risk factors for local recurrence of tumors of the upper rectum.Conclusion: Omission of radiotherapy in an adjuvant treatment setting may not jeopardize oncologic outcomes in stages II and III upper rectal cancer.
The value of calling-back patients to detect surgical site infections following orthopaedic and neurological surgeries in a tertiary care centre in Lebanon
Authors: Tannous Joseph , Zahreddine Nada Kara , Kanj Souha S
Published: July 2019

Surgical Site infections (SSIs) are a major source of morbidity, mortality and increased medical costs among patients undergoing surgeries. SSIs may be detected during hospitalization following surgery, upon readmission, through Emergency Department or clinic visits. Calling-back patients might be used to detect SSIs in patients who seek medical care in different centres. An active, patient-based, prospective surveillance for SSI following orthopaedic and neurological procedures was conducted between July and September 2016 at the American University of Beirut Medical Centre (AUBMC).

Trained infection control preventionist conducted the surveillance based on the CDC/NHSN (Centers for Disease control and Prevention/National Health Care Safety Network) definition of SSI and the NHSN methodology for data collection by calling-back patients and assessing the signs and symptoms of SSIs at 30 or 90 days after the operative procedure using a standardized checklist. Calling-back patients was initiated following an increase in the SSI rates for particular surgeons in these specialties. Rates were expressed as number of SSI in a designated specialty per 100 operative procedures of the same specialty and were benchmarked with NHSN and the International Nosocomial Infection Control Consortium (INICC) rates.

No SSIs were identified through the phone calls among the 178 patients who were assessed throughout the surveillance period. Whereas, 2 SSIs were identified through the routine surveillance of hospital re-admissions and one SSI was identified from the review of the outpatient clinic records. SSI rates remained unchanged compared to the adopted surveillance methodology and were 3.7% following neurological surgeries and zero following orthopaedic surgeries at the time of the active surveillance.

Call-back programs may be beneficial to obtain additional post-discharge surveillance information. However, patients may have a difficult time assessing their status and the possibility of developing an SSI. Moreover, this process was found to be time consuming, and was not successful in identifying additional SSIs. Re-assessment of this method is essential to examine the value of calling-back patients in detecting SSIs.
Suboptimal infection prevention and control in the healthcare culture
Authors: Cioffi Domenico , Cioffi Jane
Published: July 2019

Healthcare associated infections are one of the most common complications of hospitalised patients although

they are largely preventable through compliance with infection prevention and control standards and

guidelines. Clinical performance has been associated with culture in health care. By exploring the influence of

culture in health care on infection prevention and control practice, understanding and insight into suboptimal

IPC practice may be exposed. This paper discusses the cultural milieu of IPC practice and embedded norms

proposing a cultural shift is mandatory to address suboptimal IPC practice. Recommendations are made that a

cultural shift to blend the cure and prevention paradigms that effectively supports optimal infection prevention

and control practice be envisaged by healthcare workers and implemented.
Development of e-commerce in the area of «Greater Eurasia»: on the possibilities of Russia's participation
Authors: Nevskaya A.A. , Kondeev A.V.
Published: July 2019

The article assesses the chances of Russia's inclusion in the rapidly developing in the space of «Greater Eurasia» e-Commerce. The essence of the transformation of value chains in cross-border markets of consumer goods through e-Commerce is characterized; the existing architecture of marketplaces in Europe and Asia is considered; the limitations of our country's participation in the processes of digitalization of international trade are revealed. The information and regulatory aspects of the problem are touched upon. The conclusion, according to which Russia is able to form a competitive national infrastructure for digital trading if solve the dilemma of regulation and will also attract national digital platform for Federal information systems.
Diagnostics on characteristics of network infrastructure technology under modification of Russian natural monopoly state regulation
Authors: Belousova N.I. , Vasilieva E.M.
Published: July 2019

The process of natural monopoly Russian structure reforming and situation connected with modification the conditions of natural monopoly state regulation, list of activities and price techniques in the sphere are analyzed. There are represented the guidelines on diagnostics of infrastructure technology using natural monopoly activity indicators and taking into account network specific of transport, communications, energy and so on. Some features of realization the approaches on diagnostics and modeling natural monopoly infrastructure technologies are considered.
The roads that we do not choose (on the government «Strategy of spatial development of the Russian Federation for the period up to 2025»)
Authors: Leksin V.N.
Published: July 2019

The article analyzes the causes and predicts the consequences of the recent (in February 2019). the adoption of the «Strategy of spatial development of the Russian Federation» — a natural, according to the author, evidence of the continuation of the former regional policy of the state, including the consolidation in the future of the initiated contraction in large-city agglomerations of material, financial, human and other resources, focus on point pockets of preferential stimulated economic activity. In this regard, it is shown on what conceptual and ideological Foundation the development of the «Strategy» was based and what mechanisms of implementation are proposed in it. As a concrete example, the government of the Russian Federation adopted a «comprehensive plan for the modernization and expansion of the main infrastructure for the period up to 2024» in the development of the «Strategy», planning another «road that we do not choose».
Integration of mining and metallurgical complex: factors of industrial and corporate policy
Authors: Vinslav Yu.B. , Lunkin D.A.
Published: July 2019

The article emphasizes the need and outlines the ways of corporate relations between the mining and metallurgical segments of the mineral complex of Russia. These segments are designed to ensure the smooth and competitive functioning of the integrated process chain for the extraction of iron ore, its enrichment and production of metal products. The strategic guidelines for the development of the mining and metallurgical complex (MMC) are characterized, suggesting an increase in its diversity and innovation. The proposed instruments of the state industrial policy that stimulate the development of integrated technological chains in MMC. Recommendations on improvement of regulations of corporate policy in mining and processing plants focused on improvement of quality of integration interaction with the metallurgical enterprises are given. The principles of improving the strategic planning of companies in MMC, involving the activation of joint activities of mining and metallurgical enterprises within the integrated business.
On the role of transnational corporations in modern integration and globalization processes
Authors: Baryshnikov P.Yu.
Published: July 2019

The subject of the author's research is the development of transnational corporations (TNCs) as an organic component of modern international economic integration and globalization processes. The concept and features of TNCs are characterized. A brief historical overview of the formation and development of corporate transnationalism is proposed. Statistics on the largest TNCs are presented and analyzed. On the one hand, positive aspects of the impact of TNCs on the development of the world economy and its national components were identified, and on the other hand, the negative consequences of the expansion of these corporations for both host countries and home countries of TNCs. The relationship between TNCs and sovereign States is considered in many aspects. Thus, based on the analysis of the instruments of influence of the companies under consideration on the normative activities of the States, a shift from the interstate to the corporate legal field was recorded. One of the subjects of the article is mega regional trade agreements of a new type as a factor of increasing the contradictory impact of TNCs on the development of the world economy and its national components.
PENGARUH LATIHAN FISIK TERHADAP KUALITAS HIDUP PASIEN HEMODIALISIS
Authors: Ritianingsih Nieniek , Sahat Camalia S
Published: July 2019

Patient with chronic kidney disease (CKD), especially those on dialysis, often suffer from muscle wasting and excessive fatique. Patient continue to experience significant impairment of quality of life. Exercise in patient receiving reguler dialysis treatment is still only offered in a minority of renal units. The current study was designed to determine the effect of exercise training (intradialytic) related quality of life among patient with haemodialysis at PMI hospital Bogor. Design of the research was experiment quasi with pretest-posttest design. Thirty subjects voluntereed to participate in the study following 10 weeks (20 times) exercise training programme. Short Form-36 (SF-36) questionnaire was evaluated at beginning and end of the study. After training patient demonstrated a significant improvement in the physical component scaleof the SF-36 (from 56,6 to 64,56, P < 0,05). Intradialytic exercise training improves quality oflife (physical component scale)
Structure cristalline de la phase Li V Te O5
Authors: Darriet Jacques
Published: July 2019

La phase LiVTeO₅ a été préparée à 500° C par synthèse à l'état solide. Elle cristallise dans le système orthorhombique (groupe spatial P2₁2₁2₁) avec les paramètres a = 9,509 Å, b = 8,353 Å et c = 5,285 Å. La structure cristalline est constituée d'un réseau tridimensionnel (VTeO₅)[n fois, chargé n⁻] dans lequel le tellure possède la coordinence trois et le vanadium la coordinence cinq. Le lithium est à l'intérieur d'un tétraèdre oxygéné très déformé.
Présence de fuchsite dans les quartzites de la série charnockitique des Gour Oumelalen (nord-est de l'Ahaggar, Algérie)
Authors: Fabriès Jacques , Latouche Louis
Published: July 2019

Les quartzites verts de la série des Gour Oumelalen doivent leur couleur à la présence d'une fuchsite disséminée dans la roche. Ils font partie d'une série précambrienne ayant subi trois phases de déformation et de métamorphisme. La fuchsite, dont les propriétés physiques et chimiques ont été déterminées, a cristallisé au cours de la deuxième phase, dans les conditions du faciès amphibolite. Les arguments de terrain permettent d'écarter une origine magmatique du chrome dont la source la plus probable est constituée par de la chromite détritique présente dans le sédiment originel.
Structure et évolution thermique des oxydes de zirconium et de thorium précipités
Authors: Guymont Marcel , Livage Jacques , Mazières Charles
Published: July 2019

The structure and thermal evolution of thorium oxyde precipitates are studied by X-ray diffrection and thermal analysis. The radial distribution functions are calculated through Fourier transformation. A comparison is established with zirconium oxyde precipitates : the structure of thoria is rather microcrystalline and that of zirconia rather amorphous.
Formation de Fe2S3 cubique
Authors: Yamaguchi Shigeto , Wada H.
Published: July 2019

An iron sulfide identified as Fe₂S₃ with the spinel stucture and lattice parameter equal to 9.86 Å has been prepared in acidic aqueous medium around 80 °C. Its atomic configuration is similar to that of Al₂O₃.
Influence des germes sur la qualité radioélectrique des monocristaux de quartz de synthèse
Authors: Auvray Patrick , Regreny André
Published: July 2019

Synthetic α quartz crystals have been studied by X ray transmission topography in order to determine the influence of crystal perfection, origin (synthetic or natural quartz) and state of surface of the seeds on growth. A relation between the quality of quartz for radioelectric applications and the defects has been attempted.
Les sous-groupes isosymboliques des groupes spatiaux
Authors: Billiet Yves
Published: July 2019

Tout groupe spatial admet comme sous-groupes propres des groupes spatiaux dont le symbole cristallographique est le même que celui du groupe de départ. Les propriétés de ces sous-groupes isosymboliques et des changements de repère qui y conduisent ont été étudiées. La méthode de détermination des sous-groupes isosymboliques d'un groupe spatial est complètement exposée sur l'exemple du groupe B₂/b. Pour tous les groupes spatiaux figurent les résultats de la dérivation.
Découvertes de néphéline en mégacristaux et d'enclaves à néphéline et anorthose dans des projections volcaniques du Devès (Haute-Loire)
Authors: Blanc Yves , Mergoil-Daniel Juliette , Tempier Paul
Published: July 2019

Découverte de néphéline (Ne₇₆Ks₁₈Qz₆ % en poids) en nodules monocristallins pouvant atteindre jusqu'à 3 cm de diamètre et d'enclaves à néphéline et anorthose (Or₂₇) dans les projections stromboliennes basaltiques du Devès (Velay, Hte-Loire). Une carte provisoire d'extension est présentée.

L'association volcanique du Devès étant particulièrement déficitaire en silice et peu différenciée, deux hypothèses sont avancées quant à l'origine de ces enclaves : fragmentation d'une syénite alcaline néphélinique sous-jacente qui serait l'équivalent grenu des phonolites du Velay oriental et cristallisation en liaison avec la magmatogenèse du Devès.

Outre l'intérêt minéralogique de ce gisement, le premier de ce type signalé en France, la présence de néphéline et de l'association néphéline˗anorthose pose d'intéressants problèmes sur la magmatogenèse du Velay.
Note sur la présence de minéraux de bismuth dans un filon de barytine et fluorine à Faymont, près Le Val-d'Ajol (Vosges)
Authors: Escande Jean-Claude , Johan Zdenek , Lougnon Jean , Picot Paul , Pillard François
Published: July 2019

L'objet de cette note est de signaler la présence de minéraux de bismuth (wittichénite, emplectite, tétraédrite bismuthifère et, comme produit supergène, mixite) dans un filon quartzeux, fluoré et barytique, de la région du Val d'Ajol (Vosges). L'association ci-dessus est à rapprocher de celle de la formation « à cinq éléments » de Wittichen (Forêt Noire), qui possède les mêmes minéraux de gangue et le même âge probable de mise en place (phase palatine tardi˗hercynienne, environ 220 Ma).
The iron˗magnesium partitioning between naturally occurring coexisting olivine and Ca˗rich clinopyroxene : an application of the simple mixture model to olivine solid solution
Authors: Obata Masaaki , Banno Shohei , Mori Takeshi
Published: July 2019

Le partage de Fe et Mg entre olivine et clinopyroxène calcique a été interprété en appliquant des modèles de simple mélange pour l'olivine et de solution idéale pour le clinopyroxène. La relation entre le coefficient de partage, K et le coefficient de partage apparent, K' s'écrit :

ln K = ln K' + (1—2X) W[ol]/RT

où W[ol] est un paraètre thermodynamique dépendant de la température et de la pression, et X est le rapport Fe/(Fe + Mg) dans l'olivine. En utilisant les données expérimentales publiées sur W[ol] [, sa dépendance] avec la température a été examinée. Bien que la signification physique du terme W[ol] ne soit pas bien comprise, le coefficient de partage apparent entre olivine et clinopyroxène est sensible à la température à cause d'une grande dépendance de W[ol] de la température, et donc, ce coefficient de partage est un géothermomètre utile, spécialement à basse température.
Utilisation du modèle de F. Kohler pour le calcul de la distribution d'un élément en traces entre une solution solide binaire et une solution hydrothermale. Application à quelques tectosilicates
Authors: Lagache Martine
Published: July 2019

It is necessary to know the thermodynamic properties of the ternary (i j k) M solid solution to calculate the distribution of a trace element i between a (j k) M minerals solid solution and an aqueous vapor phase supposed to be ideal. According to the Kohler' s model, it is possible to estimate those properties from the results obtained with the bordering binary solutions (i j) M, (j k) M, and (k i) M. Moreover it is remarquable that more the excess molal Gibbs free energy of the solid solution (j k) M is strongly positive, more the trace element will be easily accepted in the solid phase. Three experimental applications support this calculation.
Jahn˗Teller effects in ferro˗magnesian minerals : pyroxenes and olivines
Authors: Walsch D. , Donnay Gabrielle , Donnay Joseph Désiré Hubert
Published: July 2019

In a crystal the replacement of Mg²⁺ in octahedral coordination by high-spin Fe²⁺ should not — even though the two effective ionic radii differ from their mean by less than 4 per cent — result in random solid solution : orbital degeneracy in the ground state increases the stability of Fe²⁺ in a distorted octahedral environment so that, if two octahedral cationic positions are available, iron (the Jahn-Teller ion) will favor the more distorted site. The occupancies of M(1) and M(2) in refined crystal structures of pyroxenes bear out this prediction : M(2) is much more distorted than M(1) and it contains most of the ferrous ion. In olivines, however, the difference in distortion between M(1) and M(2) is less extreme. M(1) is said to be « more distorted » than M(2), but the difference in the types of distortion precludes such comparison. The distortion of M(1) is « quasi-tetragonal », that of M(2) « quasi-trigonal ». Crystal-field calculations for the two sites at both the magnesium and iron end of the olivine series yield an average stabilization energy at M(1) which is 262 cm⁻¹ larger than that at M(2), yet X-ray diffraction results show very little or no ordering of iron. Dynamic Jahn-Teller effects at M(2) can be expected, since such effects are known in Mg₁₋ₓFeₓO, Ca₁₋ₓFeₓO and KMg₁₋ₓFeₓF₃. The inclusion of a Jahn-Teller stabilization energy at M(2) gives a total stabilization energy which is only 95 cm⁻¹ larger than that at M(1).
Energetic criteria for solid solution miscibility gap calculations
Authors: Urusov V. S.
Published: July 2019

L'article est une brève synthèse de la théorie énergétique des substitutions isomorphes d'éléments dans les minéraux et les composés inorganiques. Il présente quelques équations fondamentales de la théorie basée sur un modèle cristallochimique simple de solution solide. Les nomogrammes de détermination des limites de substitutions isomorphes en fonction de la température sont données ainsi que quelques exemples de calcul de la lacune de miscibilité dans des systèmes minéraux binaires. La théorie énergétique quantitative permet d'analyser les règles empiriques de l'isomorphisme.