bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-temperature ice nucleation of sea spray and secondary marine aerosols under cirrus cloud conditions
Authors: Patnaude Ryan J. , Moore Kathryn A. , Perkins Russell J. , Hill Thomas C. J. , DeMott Paul J. , Kreidenweis Sonia M.
Published: January 2024

Abstract. Sea spray aerosols (SSAs) represent one of the most abundant aerosol types on a global scale and have been observed at all altitudes including the upper troposphere. SSA has been explored in recent years as a source of ice-nucleating particles (INPs) in cirrus clouds due to the ubiquity of cirrus clouds and the uncertainties in their radiative forcing. This study expands upon previous works on low-temperature ice nucleation of SSA by investigating the effects of atmospheric aging of SSA and the ice-nucleating activity of newly formed secondary marine aerosols (SMAs) using an oxidation flow reactor. Polydisperse aerosol distributions were generated from a marine aerosol reference tank (MART) filled with 120 L of real or artificial seawater and were dried to very low relative humidity to crystallize the salt constituents of SSA prior to their subsequent freezing, which was measured using a continuous flow diffusion chamber (CFDC). Results show that for primary SSA (pSSA), as well as aged SSA and SMA (aSSA+SMA) at temperatures >220 K, homogeneous conditions (92 %–97 % relative humidity with respect to water – RHw) were required to freeze 1 % of the particles. However, below 220 K, heterogeneous nucleation occurs for both pSSA and aSSA+SMA at much lower RHw, where up to 1 % of the aerosol population freezes between 75 % and 80 % RHw. Similarities between freezing behaviors of the pSSA and aSSA+SMA at all temperatures suggest that the contributions of condensed organics onto the pSSA or alteration of functional groups in pSSA via atmospheric aging did not hinder the major heterogeneous ice nucleation process at these cirrus temperatures, which have previously been shown to be dominated by the crystalline salts. Occurrence of a 1 % frozen fraction of SMA, generated in the absence of primary SSA, was observed at or near water saturation below 220 K, suggesting it is not an effective INP at cirrus temperatures, similar to findings in the literature on other organic aerosols. Thus, any SMA coatings on the pSSA would only decrease the ice nucleation behavior of pSSA if the organic components were able to significantly delay water uptake of the inorganic salts, and apparently this was not the case. Results from this study demonstrate the ability of lofted primary sea spray particles to remain an effective ice nucleator at cirrus temperatures, even after atmospheric aging has occurred over a period of days in the marine boundary layer prior to lofting. We were not able to address aging processes under upper-tropospheric conditions.
Spatial patterns and indices for heat waves and droughts over Europe using a decomposition of extremal dependency
Authors: Szemkus Svenja , Friederichs Petra
Published: January 2024

Abstract. We present a method for the analysis and compact description of large-scale multivariate weather extremes. Spatial patterns of extreme events are identified using the tail pairwise dependence matrix (TPDM) proposed by Cooley and Thibaud (2019). We also introduce the cross-TPDM to identify patterns of common extremes in two variables. An extremal pattern index (EPI) is developed to provide a pattern-based aggregation of temperature. A heat wave definition based on EPI is able to detect the most important heat waves over Europe. As an extension for considering simultaneous extremes in two variables, we propose the threshold-based EPI (TEPI) that captures the compound character of spatial extremes. We investigate daily temperature maxima and precipitation deficits at different accumulation times and find evidence that preceding precipitation deficits have a significant influence on the development of heat waves and that heat waves often co-occur with short-term drought conditions. We exemplarily show for the European heat waves of 2003 and 2010 that TEPI is suitable for describing the large-scale compound character of heat waves.
Canopy structure modulates the sensitivity of subalpine forest stands to interannual snowpack and precipitation variability
Authors: Berkelhammer Max , Page Gerald F. , Zurek Frank , Still Christopher , Carbone Mariah S. , Talavera William , Hildebrand Laura , Byron James , Inthabandith Kyle , Kucinski Angellica , Carter Melissa , Foss Kelsey , Brown Wendy , Carroll Rosemary W. H. , Simonpietri Austin , Worsham Marshall , Breckheimer Ian , Ryken Anna , Maxwell Reed , Gochis David , Raleigh Mark , Small Eric , Williams Kenneth H.
Published: January 2024

Abstract. Declining spring snowpack is expected to have widespread effects on montane and subalpine forests in western North America and across the globe. However, the effect of this forcing at the species and hillslope scale are difficult to predict from remote sensing or eddy covariance. Here, we present data from a network of sap velocity sensors and xylem water isotope measurements from three common subalpine tree species (Picea engelmannii, Abies lasiocarpa, Populus tremuloides) across a hillslope transect in a subalpine watershed in the Upper Colorado River Basin. We use these data to compare tree- and stand-level responses to the historically high spring snowpack but low summer rainfall of 2019 against the low spring snowpacks but high summer rains of 2021 and 2022. From the sap velocity data, we found that only 40 % of the trees showed an increase in cumulative transpiration in response to the large snowpack year (2019), illustrating the absence of a common response to a major decline in snowpack. The trees that benefited from the large snow year were all found in dense canopy stands – irrespective of species – while trees in open canopy stands were more active during the years with modest snow and higher summer rains. This pattern reflects how persistent access to soil moisture recharged by snowmelt in topographically-mediated convergence zones shapes stand density. These locally dense canopies also experience high levels of summer rainfall interception that reduce summer precipitation inputs to the soil perpetuating their greater sensitivity to snowmelt inputs. The results illustrate that the progression towards a low snowpack future will manifest at the sub-hillslope scale in dense stands with significant rainfall interception and high water demands reflecting their historical reliance on snowmelt water.
A global FAOSTAT reference database of cropland nutrient budgets and nutrient use efficiency (1961–2020): nitrogen, phosphorus and potassium
Authors: Ludemann Cameron I. , Wanner Nathan , Chivenge Pauline , Dobermann Achim , Einarsson Rasmus , Grassini Patricio , Gruere Armelle , Jackson Kevin , Lassaletta Luis , Maggi Federico , Obli-Laryea Griffiths , van Ittersum Martin K. , Vishwakarma Srishti , Zhang Xin , Tubiello Francesco N.
Published: January 2024

Abstract. Nutrient budgets help to identify the excess or insufficient use of fertilizers and other nutrient sources in agriculture. They allow for the calculation of indicators, such as the nutrient balance (surplus if positive or deficit if negative) and nutrient use efficiency, that help to monitor agricultural productivity and sustainability across the world. We present a global database of country-level budget estimates for nitrogen (N), phosphorus (P) and potassium (K) on cropland. The database, disseminated in FAOSTAT, is meant to provide a global reference, synthesizing and continuously updating the state of the art on this topic. The database covers 205 countries and territories, as well as regional and global aggregates, for the period from 1961 to 2020. Results highlight the wide range in nutrient use and nutrient use efficiencies across geographic regions, nutrients, and time. The average N balance on global cropland has remained fairly steady at about 50–55 kg ha−1 yr−1 during the past 15 years, despite increasing N inputs. Regional trends, however, show recent average N surpluses that range from a low of about 10 kg N ha−1 yr−1 in Africa to more than 90 kg N ha−1 yr−1 in Asia. Encouragingly, average global cropland N use efficiency decreased from about 59 % in 1961 to a low of 43 % in 1988, but it has risen since then to a level of 55 %. Phosphorus deficits are mainly found in Africa, whereas potassium deficits occur in Africa and the Americas. This study introduces improvements over previous work in relation to the key nutrient coefficients affecting nutrient budgets and nutrient use efficiency estimates, especially with respect to nutrient removal in crop products, manure nutrient content, atmospheric deposition and crop biological N fixation rates. We conclude by discussing future research directions and highlighting the need to align statistical definitions across research groups as well as to further refine plant and livestock coefficients and expand estimates to all agricultural land, including nutrient flows in meadows and pastures. Further information is available from https://doi.org/10.5061/dryad.hx3ffbgkh (Ludemann et al., 2023b) as well as the FAOSTAT database (https://www.fao.org/faostat/en/#data/ESB; FAO, 2022a) and is updated annually.
Exploring the ocean mesoscale at reduced computational cost with FESOM 2.5: efficient modeling strategies applied to the Southern Ocean
Authors: Beech Nathan , Rackow Thomas , Semmler Tido , Jung Thomas
Published: January 2024

Abstract. Modeled projections of climate change typically do not include a well-resolved ocean mesoscale due to the high computational cost of running high-resolution models for long time periods. This challenge is addressed using efficiency-maximizing modeling strategies applied to 3 km simulations of the Southern Ocean in past, present, and future climates. The model setup exploits reduced-resolution spin-up and transient simulations to initialize a regionally refined, high-resolution ocean model during short time periods. The results are compared with satellite altimetry data and more traditional eddy-present simulations and evaluated based on their ability to reproduce observed mesoscale activity and to reveal a response to climate change distinct from natural variability. The high-resolution simulations reproduce the observed magnitude of Southern Ocean eddy kinetic energy (EKE) well, but differences remain in local magnitudes and the distribution of EKE. The coarser, eddy-permitting ensemble simulates a similar pattern of EKE but underrepresents observed levels by 55 %. At approximately 1 ∘C of warming, the high-resolution simulations produce no change in overall EKE, in contrast to full ensemble agreement regarding EKE rise within the eddy-permitting simulations. At approximately 4 ∘C of warming, both datasets produce consistent levels of EKE rise in relative terms, although not absolute magnitudes, as well as an increase in EKE variability. Simulated EKE rise is concentrated where flow interacts with bathymetric features in regions already known to be eddy-rich. Regional EKE change in the high-resolution simulations is consistent with changes seen in at least four of five eddy-permitting ensemble members at 1 ∘C of warming and all ensemble members at 4 ∘C. However, substantial noise would make these changes difficult to distinguish from natural variability without an ensemble.
Relevansi Kebijakan Fiskal pada Masa Rasulullah dan Utsman Bin Affan di Indonesia
Authors: Akbar Rizki Ramdani , Oktafiani Sonia , Ayu Niken Putri , Hidayat Faisal , Rahmah Miftahur
Published: January 2024

Islamic economics is an economic system based on sharia rules and the main legal references are the Qur'an and Sunnah. This system is constantly evolving. Sharia tax policies have existed since the time of the Prophet SAW. The profit-sharing mechanism for the Islamic State is fay', ghanima, kharaj, jizyah, ushur and khums, just like during the time of Caliph Ustman bin Affan. The purpose of this study is to reveal the Islamic economics in the Uthman bin Affan period. The research method used is library research. The results of the study show that the form of Islamic economics in the era of Ustman bin Affan (644-656) can be derived from the policies of zakat, kharaj, jizyah and price control.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Pasien di Rumah Sakit Graha Delta Husada RSUD Sidoarjo
Authors: Amalia Yustisia , Prakasa Davis Febrinanto
Published: January 2024

This research is aiming to analyze the effect of service quality consisting of, Attitutude and behavior, Accessibility and Flexibility, dan Reliability and Trustworthness to customer satisfaction, where customer satisfaction is meant by patient satisfaction. The respondents used in this research were patients of Graha Delta Husada RSUD Sidoarjo aged 21 to 60 years who underwent hospitalization in standard care rooms for more than 1 day and had passed the initial action (patients entered through emergency installations or polyspecialists), totaling 60 people. Based on the calculation of F test, a calculated F value of 42.107 was obtained with a significant level of 0.000 smaller than (α) 0.05, so that simultaneously the quality of service consisting of: Attitude and behavior, Accessibility and flexibility, Reliability and trustworthness has a significant influence on patient satisfaction at Graha Delta Husada RSUD Sidoarjo.

Abstrak

Penelitian ini bertujuan untuk menganalisis pengaruh kualitas pelayanan yang terdiri dari, Sikap dan perilaku, Aksesibilitas dan Fleksibilitas, serta Keandalan dan Kepercayaan terhadap kepuasan pelanggan, dimana kepuasan pelanggan yang dimaksud adalah kepuasan pasien. Responden yang digunakan dalam penelitian ini adalah pasien Graha Delta Husada RSUD Sidoarjo berusia 21 hingga 60 tahun yang menjalani rawat inap di ruang perawatan standar lebih dari 1 hari dan telah melewati tindakan awal (pasien masuk melalui instalasi gawat darurat atau polispesialis) yang berjumlah 60 orang. . Berdasarkan perhitungan uji F diperoleh nilai F hitung sebesar 42,107 dengan tingkat signifikan 0,000 lebih kecil dari (α) 0,05, sehingga secara simultan kualitas pelayanan terdiri dari : Sikap dan perilaku, Aksesibilitas dan fleksibilitas, Keandalan dan dapat dipercaya. mempunyai sebuah pengaruh signifikan terhadap kepuasan pasien di Graha Delta Husada RSUD Sidoarjo.
Analisis Strategi Pendistribusian Zakat Produktif Dalam Mensejahterakan Masyarakat Indonesia
Authors: Fadhlurrahman Muhammad Syafiq , Lesmana Meichio , Rosmitha Siti Nurma , F Muhammad Iqbal
Published: January 2024

Indonesia merupakan suatu Negara yang memiliki jumlah penduduk sebanyak dari Majalah bisnis ternama di AS yaitu Global Finance baru merilis peringkat Negara berdasarkan tingkatan produk domestic bruto (PDB) Perkapita dan Indonesia berada di urutan ke 122. Menurut Badan Pusat Statistik (BPS) pada bulan Maret 2021 di indonesia terdapat 27,54 juta penduduk yang berada di garis bawah kemiskinandan tolak ukur dari masyarakat yang hidup di bawah garis kemiskinan yaitu yang memiliki pendapatan Rp472.525 perkapita perbulan Zakat adalah bagian dari harta yang wajib dikeluarkan oleh setiap muslim apabila telah mencapai syarat yang ditetapkan. Dalam rukun islam zakat ditunaikan dan diberikan kepada golongan yang menerimanya (asnaf). Zakat menempati kedudukan yang sangat penting dalam islam sehingga diposisikan menjadi rukun islam yang ketiga setelah shalat. Perhitungan zakat dan angka kemiskinan, angka pekerja yang mengeluarkan zakat profesi dapat menjadi jawaban untuk meluruskan kekeliruan masyarakat yang belum menerima adanya zakat profesi. Zakat profesi yaitu zakat yang dikenakan pada penghasilan profesi apabila telah mencapai nishab. Dari ayat Al-Qur’an surat Al-Baqarah ayat 267: yang artinya “wahai orang-orang yang beriman, nafkahkanlah sebagian dari apa yang kami keluarkan dari bumi untuk kamu…” ayat tersebut menguraikan tentang nafkah yang diberikan serta sifat nafkah tersebut. perintah ayat tersebut wajib maka, semua hasil usaha apapun bentuknya wajib dizakati termasuk gaji seorang pegawai, jika gajinya sudah mencapai syarat yang ditetapkan dalam konteks zakat. Salah satu tugas lembaga pengelolaan zakat yang keberadaannya dilindungi undang-undang adalah mewujudkan peran zakat sebagai solusi untuk mengatasi kemiskinan. Zakat produktif yaitu untuk menambah atau sebagai modal usaha mustahiq. Zakat meghasilkan redistribusi komoditas pasar dari kelompok kaya ke kelompok miskin. Pada prinsipnya ada dua jalur pendstribusian zakat melalui kekayaan dan pendapatan. Yang merupakan suatu jenis distribusi yang kedua terutama jika diberikan dalam bentuk uang tunai kepada mustahik. Dua fungsi sekaligus, yaitu fungsi pendapatan dan fungsi redistribusi fungsional.
Pemberdayaan ibu rumah tangga di Kelurahan Kalibaru, Cilincing Jakarta Utara melalui kegiatan Pengabdian Kepada Masyarakat UTA’45 Jakarta
Authors: Khoirunnisa Khoirunnisa , Hidajat Koerniawan , Rahmadan Yanuar , Nabila Firdiyatul , Juniaty Risnawaty , Sari Nilam
Published: January 2024

The processing of small fish into fish sauce is an innovative process in the sustainable utilization of fisheries resources. Groundfish, which is generally considered as waste fish -as it does not have high economic value, can be transformed into value-added products such as fish sauce. This study aims to explore and develop the production process of fish sauce from low-cost fish, as well as to analyse the economic potential of this low-cost fish. The research method involves the stages of selecting suitable low-cost fish, processing the fish into soy sauce raw materials, and making fish sauce through fermentation. The economic analysis involved estimating production costs, selling prices, and potential profits. The Kalibaru Subdistrict, Cilincing, North Jakarta has great potential in the development of the fisheries sector. To improve the sustainability of fisheries in this area, innovation is key. One of the potentials from the Kalibaru Subdistrict is groundfish. The processing of raw fish into fish sauce allows for a more efficient and sustainable utilization of fishery resources. The fermentation process not only increases the nutritional value of fish sauce but also provides economic sustainability for local communities. In addition, involving housewives provides a positive impact on local economic empowerment and increases awareness of the value-added potential of fishery products.
Aswang contra aswang: Interrogating the drug war chaos through Alyx Arumpac’s Aswang (2019)
Authors: Reyes Raniel
Published: January 2024

In this research, I seek to interrogate Rodrigo Duterte’s “war-on-drugs” through the documentary film Aswang (Arumpac, 2019). In the first part of this paper, I revisit the aswang phenomenon against the backdrop of the Philippine folkloric tradition and some evolving issues in the Philippine society. Before I narrate and dissect the indispensable aspects of the film, I explain first Gilles Deleuze and Felix Guattari’s theory of chaosmosis against the backdrop of the neoliberal capitalist chaos. Subsequently, I theorize the aswang as an aesthetic principle capable of traversing other worlds, disciplines, and scholarship. I use the film’s revolutionary potentials as an impetus to explore other artistic productions and community—rehabilitation initiatives critical of Duterte’s drug war. In the third part of the paper, I use the film in diagnosing the drug war’s secularized aswang­­—an authoritarian flattening and superimposition of chaos. In this vein, Aswang metamorphoses into a political principle that can antagonize the repressive configurations of Duterte’s anti-chaos chaos. Ultimately, the fusion of the aesthetic and the political seeks to transform the Aswang into a vector of transformation, resistance, and hope, which I call post-Aswang.
Svenska superhundraåringar
Authors: Lindberg Jimmy
Published: January 2024

Sveriges folkbokföringssystem är ett av de mest avancerade och omfattande i världen, med en historia som sträcker sig över flera århundraden. Detta system gör det möjligt att verifiera åldersanspråken på i princip alla inrikes födda invånare under de senaste tre århundradena, något som är av särskild vikt när man studerar våra allra äldsta.

I denna studie kunde 28 personer av nordisk härkomst verifieras ha uppnått en ålder av 110 år eller mer i Sverige fram till år 2022. Verifieringen gjordes genom att använda det svenska folkbokföringssystemet och offentligt tillgängliga släktforskningsresurser.

 

Swedish supercentenarians

Sweden's population registration system is among the most advanced and comprehensive in the world, with a history spanning several centuries. This system facilitates verification of age claims of all native-born inhabitants during the past three centuries, something that is of importance when studying the oldest old.

In this study, I could verify 28 persons of Nordic de­scent that reached the age of 110 years in Sweden untill the year of 2022. Verification was achieved by utilizing the Swedish population registration system and publicly available genealogy resources.
Cellular Viability and Nitric Oxide Detection in Response to Maraviroc Incubations with Axenic C6 Glioma and PC-12 Neuronal Cells in vitro
Authors:   Department of Chemistry, Illinois State University, Normal, IL 61790, USA, Jones Marjorie A
Published: January 2024

Brain cancers, such as Glioblastoma Multiforme (GBM), exploit the bodys own immune system to support tumor growth within their microenvironment. GBM, an incurable cancer known for its highly invasive characteristics, utilizes various pro-inflammatory pathways to mediate the bodys response, one of them being the CCR5 signaling pathway.
Whether is the Logic of Russian Roulette Appropriate for Assessing Individual Cancer Risks of Breast Cancer Mutation Carriers among their Clusters?
Authors:   Josip Juraj Strossmayer University of Osijek, Medical Faculty, J Huttlera 4, Osijek 31000, Croatia, Kurbel Sven
Published: January 2024

Breast and ovarian cancers can result from an inherited mutation that runs in the family. An unsolved question is the individual risk for a mutation carrier within her family cluster at some point in time.
On development of Fluid-Structure Interaction Computational Methods in the context of SPH
Authors: Khayyer Abbas
Published: January 2024

This talk presents a concise review on the state-of-the-art of developments and future perspectives corresponding to FSI solvers developed within the SPH context. The talk reviews and highlights the potential robustness of entirely Lagrangian meshfree FSI solvers, as new generation computational methods, in reproducing FSI corresponding to extreme events and portrays the future perspectives for systematic developments towards reliable engineering applications with respect to rapid advances in technology and emergence of so-called advanced materials that can result in complex and highly non-linear structural responses. Accordingly, the necessity for reproduction of comprehensive structural responses, including viscoelastic, elastoplastic and progressive damages/failures, by the advanced FSI solvers developed within the SPH context will be highlighted. In this regard, extensions of the structure model are suggested to be conducted in a variationally consistent framework to ensure stability, accuracy and physical reliability including thermodynamic consistency. As an important step for coherent extension of SPH-based structure models towards reproducing viscoelastic structural responses, a brief background of corresponding mathematical numerical modelling is presented along with some numerical results achieved by an extended Hamiltonian and thus variationally consistent SPH model. Another important, yet commonly overlooked aspect that will be highlighted corresponds to the numerical resolution of the continuity equation in the context of SPH for fluids, i.e., achieving physically consistent density and velocity-divergence fields.
Avaliação da germinação das sementes de maracujá-amarelo (Passiflora edulis) submetida a diferentes métodos de superação de dormência
Authors: De Oliveira Rafaela Rodrigues , Da Silva Deivisson Ferreira , Monzani Rodrigo Martins
Published: January 2024

A principal forma de propagação do maracujazeiro é através de sementes, no entanto, essas apresentam problemas de dormência física que atrasam o processo de germinação. O presente trabalho avaliou a taxa de germinação de sementes de maracujá-azedo (Passiflora edulis Sims) quando submetidas a tratamentos convencionais para quebra de dormência. Foram realizados tratamentos de escarificação mecânica, escarificação ácida, estratificação térmica, hidro condicionamento e um controle. O delineamento experimental utilizado foi o inteiramente casualizado, com 6 tratamentos e 8 repetições em cada um.  Adotou-se o método de germinação sobre papel germitest em incubadora BOD (Biochemical Oxygen Demand) a uma temperatura de 24°C, adequada à espécie de acordo com o RAS (Regras para análise de sementes). Foram analisadas as variáveis de porcentagem de germinação, índice de velocidade de germinação (IVG), tempo médio para germinação (TMG) e velocidade média de germinação (VMG). As análises foram realizadas a cada dois dias durante um período de 26 dias após o início do ensaio. Com exceção do tratamento térmico, os demais influenciaram positivamente na germinação da espécie. Conclui-se que, apesar da dormência física ser uma característica presente nas sementes de maracujá, pode ser superada através de tratamentos convencionais.
Predicting colorectal cancer prognosis based on long noncoding RNAs of disulfidptosis genes
Authors: Wang Kui-Ling , Chen Kai-Di , Tang Wen-Wen , Chen Ze-Peng , Wang Yu-Ji , Shi Guo-Ping , Chen Yu-Gen
Published: January 2024

BACKGROUND

A recently hypothesized cause of cell death called disulfidptosis has been linked to the expansion, emigration, and vascular rebuilding of cancer cells. Cancer can be treated by targeting the pathways that trigger cell death.

AIM

To discover the long non-coding RNA of the disulfidaptosis-related lncRNAs (DRLs), prognosis clinical survival, and treat patients with colorectal cancer with medications.

METHODS

Initially, we queried the Cancer Genome Atlas database to collect transcriptome, clinical, and genetic mutation data for colorectal cancer (CRC). Training and testing sets for CRC patient transcriptome data were generated randomly. Key long non-coding RNAs (lncRNAs) related to DRLs were then identified and evaluated using a least absolute shrinkage and selection operator procedure, as well as univariate and multivariate Cox regression models. A prognostic model was then created after risk scoring. Also, Immune infiltration analysis, immune checkpoint analysis, and medication susceptibility analysis were used to investigate the causes of the different prognoses between high and low risk groups. Finally, we validated the differential expression and biomarker potential of risk-predictive lncRNAs through induction using both NCM460 and HT-29 cell lines, as well as a disulfidptosis model.

RESULTS

In this work, eight significant lncRNAs linked to disulfidptosis were found. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of differentially expressed genes between high- and low-risk groups from the prognostic model showed a close relationship with the immune response as well as significant enrichment in neutrophil extracellular trap formation and the IL-17 signaling pathway. Furthermore, significant immune cell variations between the high-risk and low-risk groups were seen, as well as a higher incidence of immunological escape risk in the high-risk group. Finally, Epirubicin, bortezomib, teniposide, and BMS-754807 were shown to have the lowest sensitivity among the four immunotherapy drugs.

CONCLUSION

Our findings emphasizes the role of disulfidptosis in regulating tumor development, therapeutic response, and patient survival in CRC patients. For the clinical treatment of CRC, these important LncRNAs could serve as viable therapeutic targets.
Inflammatory response in gastrointestinal cancers: Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications
Authors: Fang Ze-Xuan , Chen Wen-Jia , Wu Zheng , Hou Yan-Yu , Lan Yang-Zheng , Wu Hua-Tao , Liu Jing
Published: January 2024

Chronic inflammation is known to increase the risk of gastrointestinal cancers (GICs), the common solid tumors worldwide. Precancerous lesions, such as chronic atrophic inflammation and ulcers, are related to inflammatory responses in vivo and likely to occur in hyperplasia and tumorigenesis. Unfortunately, due to the lack of effective therapeutic targets, the prognosis of patients with GICs is still unsatisfactory. Interestingly, it is found that six transmembrane epithelial antigens of the prostate (STEAPs), a group of metal reductases, are significantly associated with the progression of malignancies, playing a crucial role in systemic metabolic homeostasis and inflammatory responses. The structure and functions of STEAPs suggest that they are closely related to intracellular oxidative stress, responding to inflammatory reactions. Under the imbalance status of abnormal oxidative stress, STEAP members are involved in cell transformation and the development of GICs by inhibiting or activating inflammatory process. This review focuses on STEAPs in GICs along with exploring their potential molecular regulatory mechanisms, with an aim to provide a theoretical basis for diagnosis and treatment strategies for patients suffering from these types of cancers.
Морфологические характеристики растений-регенерантов малины при хемотерапии от Raspberry bushy dwarf virus in vitro
Authors: Hashenka Volha , Kukharchyk Natallia , Prodaniuc Leonid , Chernets Aleksandr
Published: January 2024

Field and micropropagated plants were tested for the presence of RBDV by DAS-ELISA and PCR. For in vitro therapy, plants with a proven absence of ArMV, ApMV, RpRSV, TBRV, TomRSV, SLRV, CMV, TRSV and infected with Raspberry bushy dwarf virus (RBDV) were selected.Virazole and salicylic acid at concentrations of 30, 50 and 70 mg/l were used as antiviral preparation.Low phytotoxicity of salicylic acid and high phytotoxicity of virazole were established. Long-term use of virazole, at concentrations of 50 and 70 mg/l, by the end of the 3rd passage leads to the complete death of microshoots. The studies were carried out within the framework of the project „Development of biotechnological methods (in vitro and ex vitro) obtaining virus-free material from the raspberry bushy dwarf virus” in order to increase the productivity of industrial raspberry plantations.
Research of innovative technology of sour-milk product using raw materials for detoxification of contomenants
Authors: Alimardanova M. K. , Bakiyeva V. M. , Ciprovica I.
Published: January 2024

This article focuses on the possibilities and methods of integrating enterosorbents into the composition of yoghurts in order to increase the body's ability to eliminate heavy metals. Not only the perspectives of this introduction are considered, but also the different methods of implementation, creating promising avenues for the development of functional products that promote detoxification of the body. This research represents not only a contribution to the field of food innovation, but also a response to the current challenges of heavy metal levels in the environment and the desire to improve the health and well-being of society.

This study examines the potential of using a polycomponent blend of hawthorn and mountain ash syrup, activated charcoal as a control and the dietary supplement RotovitCardio as enterosorbents. These natural ingredients not only provide sustainable options, but also have the potential to improve the way heavy metals are eliminated from the body through innovative products such as yoghurts. This approach not only reduces the cost of production, making the product more affordable, but is also actively embedded in the environmental paradigm, providing an answer to the challenges of strain on natural resources. These components, taken from different sources, emphasise the diversity of the substances investigated and offer opportunities to understand differences in application and sorption capacity. In this context, analysing pectin-containing, porous products provides a fascinating insight into their potential to create products that harmonise health care and responsibility to nature. This innovative approach not only forms the basis for functional products, but also supports the idea of sustainable consumption, making it an important step towards future wellbeing and environmental sustainability.
Investigation of rheological properties of zein dough and its qualitative indicators
Authors: Akshorayeva G. D. , Kakimov M. M. , Nurtayeva A. B. , Utarova N. B. , Mashanova N. S.
Published: January 2024

Since gluten-free dough lacks structuring gluten, it should be replaced by hydrocolloids or other water-binding compounds, such as guar gum, xanthan or hydroxypropylmethylcellulose. Typically, gluten-free bread recipes contain higher amounts of starch and are processed with more water compared to wheat and rye doughs, resulting in a liquid dough consistency. As a consequence, the overall nutritional value of these breads is not well balanced. They are rich in carbohydrates and lack dietary fiber. Zein is a unique substitute for gluten in a gluten-free system because of its viscoelastic properties similar to gluten. Corn grain prolamin, zein, has shown some promise in behaving like wheat gluten because it can form a viscoelastic protein network when the protein is held and mixed at 35°C or more, which is above its glass transition temperature (Tg). Zein (corn prolamine) can exhibit viscoelastic functionality similar to gluten in aqueous dough systems when heated above its glass transition temperature (Tg). These zein-based doughs exhibit a fibrous network that also exhibits characteristics similar to those of gluten-based doughs. However, such zein-based doughs have limited gas-holding capacity and are significantly more stretchable than gluten-based doughs. In this paper, we investigate the rheological properties of zein-based dough and its quality parameters.
Justification of progressive technology for drying vegetables and corn
Authors: Murzabaev B. A. , Kantureyeva G. O. , Raisov B. O.
Published: January 2024

Today, from the industrial applications point of view, getting dry food products by infrared radiation is considered the most relevant and perspective. Such properties of any object as absorption and emission of radiation in the infrared spectrum give possibility to dry them at moderate temperatures and rapidly. This technology makes it possible to gain dry items with high shelf-life due to their resistance to microorganisms. Infrared drying of products reduces drying time several times. As a result, the quality of ready items is very high and in addition ecologically pure. Also the form of cutting of raw materials before drying has some influence on time of process. The objects of study were samples of vegetables and corn planted in the experimental plot Kainar Bulak (Shymkent).During the drying process, vegetables as carrot and beet which were broken in the form of shavings reached required moisture 12.30% and 11.50% accordingly in two and half hours. Samples in the form of cubes were dried to these numbers only in three hours. Additionally, performed experiments indicate that there is no need for preliminary heat treatment (blanching) of samples. Reducing the time and temperature of heat treatment for corn also gave positive results. Thus, drying chopped vegetables and corn for further use in the food industry using infrared radiation is promising and cost-effective.
Information technology for weather forecast based on modern platform solutions
Authors: Mukashev D. S. , Abitova G. A.
Published: January 2024

Weather forecasting plays a crucial role in numerous industries and activities, ranging from agriculture and energy to tourism and transportation. In recent years, information technologies have significantly enhanced the capabilities of weather forecasting, providing more accurate and timely data. This article explores innovative information technologies employed in weather forecasting and their impact on modern practices. It highlights the utilization of cloud computing and data storage for managing vast amounts of meteorological data, enabling the use of more precise forecasting models. Additionally, the article discusses the integration of Internet of Things (IoT) and sensor networks, which facilitate the collection of weather data from diverse sources and contribute to localized and real-time weather predictions. Artificial intelligence (AI) and machine learning techniques are also examined for their ability to analyze large datasets, identify patterns, and improve forecast accuracy. Finally, the article emphasizes the importance of advanced data visualization techniques in effectively conveying weather information to end-users. By harnessing these information technologies, weather forecasting continues to advance, empowering various industries and enhancing decision-making processes.
The study of the nutritional value of the national product «Kurt» produced at the enterprises of the East Kazakhstan region and the Abai region
Authors: Zhakupbekova Sh. , Kalibekkyzy J. , Maizhanova A. O. , Kyrykbaeva Sh. T. , Kapshakbayeva Z. V.
Published: January 2024

The article presents the results of the physico-chemical parameters of the product "Kurt", produced by limited liability partnerships and individual entrepreneurs of the East Kazakhstan region and the Abai region.

Kurt is a versatile fermented milk product that is added as a seasoning to various dishes and consumed as a separate food product. It is a good source of macro- and micronutrients in an easily digestible form for the body, contributing to the maintenance of beneficial intestinal microflora. The product is popular among children and adults and is in great demand as a healthy food product [1].

In this regard, the study of the nutritional and biological value and quality of kurt is an urgent task.

The purpose of the study is to study the nutritional value of the national fermented milk product "Kurt", produced at enterprises of the East Kazakhstan region and the Abai region.

When determining the nutritional value of the national product "Kurt", physico-chemical parameters (mass fraction of protein, fat, ash, moisture, salt) were determined in 3 types of kurt of the most common enterprises of the East Kazakhstan region and the Abai region: Vostok-Moloko Corporation LLP, Bagration Ulan LLP, Individual Entrepreneur R.G.Petrosyan. The research was conducted at the V. M. Gorbatov Federal Scientific Center of the Food System of the Federal State Budgetary Scientific Institution of the Russian Academy of Sciences, Moscow.
Avaliação dos teores de ferro em farinhas de trigo fortificadas, São Paulo, Brasil
Authors: Kira Carmen Silvia , Buzzo Márcia Liane , Carvalho Maria de Fátima Henriques , Duran Maria Cristina , Sakuma Alice Momoyo
Published: January 2024

A anemia por carência de ferro é o distúrbio nutricional mais comum em todo o mundo. Este problema atinge principalmente crianças e mulheres em idade reprodutiva, em função desses grupos serem mais vulneráveis à carência de ferro. Em virtude da natureza global do problema e sua importância à saúde pública, muitos programas têm sido desenvolvidos para reduzir a prevalência de distúrbios causados por deficiência de ferro. Assim, desde 2002, a fortificação de farinhas com ferro tornou-se obrigatória no Brasil. A carência de ferro pode causar diminuição da imunidade e efeitos adversos no desenvolvimento mental e motor. Por outro lado, o excesso de ferro pode promover o risco de câncer e o aumento de problemas cardiovasculares. Neste contexto, é importante que os produtos fortificados sejam controlados para que os teores de ferro estejam dentro dos parâmetros estabelecidos. Foram analisadas 85 amostras de farinha de trigo fortificadas com ferro, de diferentes marcas, para uso industrial e doméstico. Do total de amostras, 65,9% apresentaram teores de ferro fora do intervalo de tolerância, em relação ao valor declarado na rotulagem, o que comprova a necessidade de efetuar o controle no procedimento de adição de ferro em farinhas de trigo, por parte dos moinhos.
Avaliação das condições higiênico-sanitárias de cominho e pimenta do reino em pó comercializados em cidades do Estado de São Paulo, Brasil, mediante a presença de matérias estranhas
Authors: Graciano Rejane Alexandre S. , Atui Márcia Bittar , Dimov Márcia N.
Published: January 2024

A pesquisa de sujidades leves presentes nos alimentos é de fundamental importância para manutenção da qualidade física, sanitária e nutricional do produto. O objetivo deste estudo foi verificar as condições higiênico-sanitárias de amostras de cominho e pimenta do reino em pó comercializados em cidades do Estado de São Paulo. Foram analisadas 69 amostras de pimenta do reino em pó e 47 amostras de cominho em pó, adquiridas no comércio de São Paulo, Campinas, Ribeirão Preto, Santo André, São José do Rio Preto e Sorocaba no período de abril de 1999 a maio de 2000. As amostras dos condimentos em estudo foram analisadas nos Laboratórios de Microscopia Alimentar do IAL Central e Regional de S.J.R.P. Foram utilizados os métodos de flutuação descritos pela Association of Official Analytical Chemists (AOAC) International, 17ª ed., 2000. De acordo com os resultados obtidos observou-se que das 47 amostras de cominho analisadas, 44 continham fragmentos de insetos, 3 continham ácaros e 11 pêlos de roedor. Em relação às amostras de pimenta do reino, das 69 analisadas, 68 continham fragmentos de insetos, 17 ácaros, 16 pêlos de roedor, além de outras sujidades. De acordo com a Resolução RDC no 175 de 8 de julho de 2003, 11 (23,4%) amostras de cominho e 16 (23,2%) amostras de pimenta do reino são consideradas impróprias ao consumo por conter pêlos de roedor.
Determinação espectrofotométrica de ciclamato de sódio em alimentos e bebidas dietéticas e de baixas calorias
Authors: Camargo Mônica C. R. de , Toledo Maria Cecília F.
Published: January 2024

O presente estudo teve como objetivo determinar os teores de ciclamato de sódio em adoçantes de mesa líquido, adoçantes em pó, refrigerantes diet/light, chás diet/light, iogurtes light, néctares light, além de preparados sólidos para refresco light, comercializados na região de Campinas, SP. A determinação deste edulcorante foi feita por espectrofotometria de UV, após sua derivação a N,N-diclorociclohexilamina. A absorbância foi medida em um espectrofotômetro Varian, Modelo Cary 50, a 314 nm usando o ciclohexano como referência. Os teores de ciclamato de sódio variaram de acordo com o produto analisado, situando-se na faixa de 64,9 a 95,0 mg/mL em adoçantes de mesa, 79,0 a 94,4 mg/g em adoçantes em pó, 36,1 a 101,0 mg/100mL em refrigerantes diet/light, 22,7 a 54,0 mg/100mL em chás diet/light, 83,6 a 105,0 mg/100mL em néctares light e de 83,6 a 122,5 mg/100mL em iogurtes light. Em uma única marca de preparado sólido para refresco light analisada, a quantidade média encontrada para o edulcorante foi de 28,2 mg/100mL. De modo geral, a concentração de ciclamato de sódio não excedeu o limite máximo estabelecido pela legislação brasileira para cada uma das categorias de alimentos estudadas.
Detecção de Vibrio cholerae O1 em ostras utilizando anticorpo monoclonal em ensaio de aglutinação
Authors: Ristori Christiane Asturiano , Rowlands Ruth Estela Gravato , Jakabi Miyoko , Gelli Dilma Scala , Scola Mônica C. G. , Gaspari Elizabeth N. de
Published: January 2024

O V. cholerae sorogrupo O1 é o agente etiológico da cólera pandêmica, sendo considerado dentre os víbrios patogênicos ao homem, o mais importante. Os sintomas das infecções por esta bactéria variam de diarréia branda a doença grave podendo até levar a óbito. Dentre os alimentos marinhos, as ostras representam uma das principais vias na transmissão de cólera. Os métodos convencionais para detecção do V. cholerae O1 são laboriosos e demorados havendo, portando, a necessidade de implantar métodos rápidos, sensíveis, específicos, simples e de baixo custo. O objetivo deste estudo foi avaliar a técnica de aglutinação de partículas de látex sensibilizadas com anticorpo monoclonal (AcMo) na detecção de V. cholerae O1 em ostras, contaminadas laboratorialmente. A técnica de aglutinação com látex sensibilizado detectou 1,2x102 UFC da bactéria (diluição 1/32). As amostras de ostras utilizadas para contaminação originalmente não continham V. cholerae, mas outras bactérias foram detectadas, tais como: Proteus mirabilis, Pseudomonas spp. e outros víbrios. O presente estudo demonstrou que a detecção de V. cholerae em alimentos foi reduzida para 18 horas, considerando que pela metodologia convencional a análise é finalizada, em média, em 7 dias. O AcMo produzido apresentou uma sensibilidade e especificidade de 100% para V. cholerae.
Citopatologia uterina em laboratório de saúde pública: impacto dos dados de 20 anos (1984-2003)
Authors: Yamamoto Luzia Setuko Umeda , Saito Simone , Pereira Sonia Maria Miranda , Utagawa Maria Lucia , Longatto-Filho Adhemar
Published: January 2024

O objetivo deste estudo foi identificar a distribuição dos diagnósticos citológicos pelo método de Papanicolaou das lesões pré neoplásicas e neoplásicas nos diferentes grupos etários no período de 20 anos. Foram utilizados dados retrospectivos dos diagnósticos citológicos cérvico-vaginais realizados no período de 1984 a 2003 no Setor de Citologia Oncótica. A distribuição dos diagnósticos de 1.020.853 amostras citológicas foi analisada por faixa etária em quatro intervalos de 5 anos (4 quinqüênios). Das amostras analisadas, 27.314 (2,68%) casos foram inadequados, 980.985 (96,09%) foram negativos e 12.554 (1,23%) lesões intraepiteliais e câncer. Neste período, o pico de LSIL foi observado entre a faixa etária dos 20-24 de idade, HSIL foi mais freqüente no intervalo entre 30-34 anos de idade, e SCC/ADENO Ca foram acima dos 50 anos de idade. Nas mulheres entre 15-19 anos de idade foi observado acentuado aumento na freqüência de LSIL nos quatro qüinqüênios, de 66 (9,19%) no primeiro, 109 (9,83%) no segundo, 441 (17,46%) no terceiro e 467 (15,97%) no último. A qualidade dos programas de prevenção de câncer de colo uterino pode ser medido pela freqüência das lesões do tipo LSIL. Os resultados do presente estudo são concordantes com os de outros programas contínuos e importantes para evitar a mortalidade em virtude dessas lesões.
Aspectos morfológicos e morfométricos do cérebro de ratos na intoxicação crônica pelo organofosforado metamidofós
Authors: Perez Nilda M. , Calore Edenilson Eduardo , Vilela-de-Almeida Liz , Narciso Emerson S. , Puga Flávio R.
Published: January 2024

Foram descritos distúrbios neurológicos sutis após intoxicação por organofosforados. Estudos experimentais relataram necrose de neurônios, particularmente nos animais que apresentaram convulsões. O objetivo do presente trabalho foi investigar se ratos (que não tenham apresentado convulsões) expostos a um agente organofosforado, apresentaram alterações morfológicas em regiões específicas do cérebro. Os animais receberam 2.5 ou 5.0 mg/kg peso de metamidofos, uma vez por semana, por dois meses e foram decapitados dois meses e sete dias após a primeira administração da droga. Foi observada atrofia da camada molecular do córtex parietal sem perda neural em regiões específicas do cérebro. Isto pode ser devido a atrofia ou à perda de ramificações neurais mas sem perda de corpos neuronais.