bluuebunny/crossref_metadata_2025 huggingface dataset:
HEART ATTACK PREDICTION SYSTEM USING MACHINE LEARNING TECHNIQUE
Authors: M Varun
Published: August 2023

Cardiovascular disease is currently the leading cause of death in high-income countries and is projected to become the top global cause of death by 2030. In the United States, heart disease, including conditions like coronary heart disease, hypertension, and stroke, remains the primary cause of death. According to the American Heart Association's 2019 update, approximately 46% of US adults, equivalent to 116.4 million people, are estimated to have hypertension based on the new 2017 Hypertension Clinical Practice Guidelines. The impact of cardiovascular disease is profound, with a person dying from CVD every 38 seconds, resulting in approximately 2,303 CVD-related deaths per day based on 2016 data. Stroke, as a critical cardiovascular event, accounts for about 389.4 deaths daily, with a stroke-related death occurring every 3.70 minutes, according to the same data. The heart's essential function of pumping blood throughout the body makes any malfunction potentially fatal, leading to organ failure, including the brain, within minutes. Contributing factors to the rising incidence of heart-related diseases include unhealthy lifestyle choices, work-related stress, and poor dietary habits, posing a significant global health concern. According to the World Health Organization, heart-related diseases cause approximately 17.7 million deaths annually, representing 31% of all global deaths. This worrisome trend is also apparent in India, where heart-related diseases have become the leading cause of mortality. To combat the increasing rates of heart- related diseases, particularly among younger individuals, it is vital to develop an early detection system for heart stroke symptoms to prevent fatalities. This project aims to analyze heart disease datasets and utilize feature selection techniques to construct a high-accuracy model using the best-performing machine learning algorithms. By deriving valuable insights from the data, the objective is to contribute to the prevention and improved management of heart- related conditions.
EXPLORING EMPLOYEE ENGAGEMENT STRATEGY AND ITS IMPACT OF EMPLOYEE PERFOMANCE IN IT SECTOR
Authors:   Assistant Professor – Faculty of Management Studies (BBA) PES University, Bangalore, Ravi Revathi
Published: August 2023

This paper talks about the relationship between the job engagement and performance of an employee in IT sector. It also talks about the various strategies which can be implemented by the company or the employer in order to increase the overall employee engagement in the company so that the performance of the employee also increases.
QUALITY CONTROL OF POWER SYSTEM USING DG_UPQC WITH AI BASED SWITCHING MODULATION TECHNIQUE
Authors: Mandal Ashok Kumar
Published: August 2023

Problems with power quality (PQ) are those which cause the voltage and/or current to deviate from the nominal sine wave. Voltage sags/swells and harmonic currents are typically the focus of P-Q issues. Recently, it has become more common to take Custom Power (CP) devices into usage for addressing these power quality issues. The Unified Power Quality Conditioner (UPQC), which simultaneously lowers load current and supply voltage concerns, is one of the CP devices. In this study, we suggest the UPQC in combination with a hybrid solar-wind energy resource to address power quality (PQ) issues in power systems. The UPQC proves effective in mitigating voltage sags/swells, harmonic currents, and enhancing power outcomes. Through simulations in MATLAB/SIMULINK, the proposed system achieves a 3.5% increase in active power, reduces reactive power to 52.85 Var, and enhances the power factor from 0.91 to 0.96. Additionally, it significantly reduces Total Harmonic Distortion (THD %) in both current as well as voltage waveforms, making UPQC a promising solution for enhancing power quality in hybrid energy systems. Keywords: UPQC, Evolution Strategy (ES), Distributed generation (DG), Power Quality, Hybrid system.
Empowering Girls in STEM: The Transformative Impact of Early Exposure to Education in Male-Dominated Fields
Authors: Agarwal Anwita
Published: August 2023

This research paper examines the transformative impact of early exposure to education in male-dominated fields of Science, Technology, Engineering, and Mathematics (STEM) on empowering girls. Through an extensive literature review and empirical analysis, the study investigates the significance of introducing women to STEM education and activities from an early age. The research highlights the positive correlation between early exposure to STEM and their confidence, self-efficacy, and determination to excel in traditionally male-dominated fields. By delving into the experiences and perceptions of girls who have undergone early STEM exposure, this paper sheds light on the barriers they overcome and the opportunities that arise from such interventions. The findings emphasize the crucial role of early empowerment in narrowing the gender gap in STEM and fostering a more inclusive and equitable workforce for the future. Additionally, the study proposes actionable recommendations for educators, policymakers, and stakeholders to further support and sustain the momentum of empowering girls in STEM through early education initiatives. Index Terms- Early Exposure Empowerment Gender Equality STEM Education
Deep Reinforcement Learning Based Trajectory Planning Under Uncertain Constraints
Authors: JOURNAL IJSREM
Published: August 2023

Trajectory planning in complex environments with uncertain constraints is a challenging problem with numerous applications in robotics, autonomous vehicles, and aerial systems. Deep Reinforcement Learning (DRL) has emerged as a promising approach to address this issue by enabling agents to learn optimal policies through trial and error. This research paper presents a comprehensive study on employing DRL techniques for trajectory planning under uncertain constraints. We propose a novel framework that combines deep learning models with reinforcement learning algorithms to generate safe and efficient trajectories whileaccounting for environmental uncertainties. The performance of the proposed approach is evaluated through simulations and real-world scenarios, showcasing its effectiveness in handling various uncertainty sources and providing robust trajectory planning solutions.
CLASSIFICATION AND DETECTION OF TOMATO LEAF DISEASE
Authors:   Maharaja Institute of Technology, Belavadi, Mandya, India, 571477, S A Manjunatha
Published: August 2023

The tomato crop is a significant staple with a high commercial value on the Indian market and is produced in enormous quantities. Diseases are harmful to the health of the plant, which has an impact on its growth. It is essential to monitor the progress of the farmed crop to ensure minimal losses. Many different tomato diseases attack the crop's leaves at frightening rates. The primary goal of the proposed effort is to identify a simple method for detecting tomato leaf disease while employing limited computational resources to produce outcomes that are comparable to state-of- the-art. Automatic feature extraction is used by neural network models to help categorize the input image into the appropriate illness classifications. The average accuracy of this suggested system is between 94 to 95 percent, demonstrating the viability of the neural network approach even in challenging circumstances. Keywords: Agriculture, Convolution Neural Network, machine learning, Support Vector Machine.
Prediction and Classification Lung Cancer using Machine Learning
Authors: G R Shruthi
Published: August 2023

In wealthy nations, lung cancer is one of the most lethal diseases, and early detection is challenging. One of the most difficult problems people have faced recently is lung cancer diagnosis and treatment. Every day, early tumor diagnosis will continue to save many lives all around the world. This research presents a strategy that integrates a Convolutional Neural Network (CNN) with the AlexNet Network Model to categorize lung cancers as benign or malignant. One of the transfer learning models is AlexNet CNN. Here, in this project, the aim will be focussed onto list, discuss, and analyse several ML algorithm to classify and detect lung cancer and its stages. The proposed CNN achieves a high degree of accuracy, which is more effective than the accuracy attained by traditional neural network systems. Keywords: Alex Net , Convolution Neural Network, Machine learning, , Transfer learning, Tumor.
AUTOMATIC FRUIT DETECTION USING MULTILAYER NEURAL NETWORK
Authors: C M Manasa
Published: August 2023

Agriculture has become an important thing in everyday life .Among this, fruits are a great thing in everyday life. Classification of fruits based on their accuracy is a decent approach to all the fruit sellers. There is much parallelism between apple and cherry and various kinds of similarities are present in many types of fruits, so the classification plays an important role. However, there are troubles in fruit classification using machine learning algorithms like Support Vector Machine (SVM) and Convolution Neural Network (CNN). So, the methods of CNN, pooling layers and fully connected network have been applied to overcome the problems. The CNN and pooling layers have been applied to extract the features of the fruits. Keywords: Agriculture, Convolution Neural Network, machine learning, Support Vector Machine.
GREEN BUILDING- A BUSINESS REPORT OF THE COST AND BENEFITS FOR DEVELOPERS, INVESTORS AND OCCUPANTS
Authors: Verma Rishabh , Kharvi Nikunj
Published: August 2023

Many studies and reports have discussed various aspects of the "business case" for green buildings in recent years, but this report is an attempt to compile all reliable data from around the globe into a single, comprehensive resource that includes international examples and thought pieces from top experts. The final section of this study explores the effects that a greener built environment can have on a macro scale as well as how this can be accomplished. This report examines the business costs and advantages of green building in essential categories. According to the research, there are a variety of compelling advantages to building sustainably that are enjoyed by various stakeholders over the course of a building's life. However, whether it is possible to put a monetary value on the advantages of green buildings has remained debatable. This is information that real estate lenders and the investment community need. Do green buildings command a higher price when it comes to buying and renting? Are tenants and occupants finding them more appealing? KEY WORDS Green building, business, developer, inverstor, building’s life, cost, consumption, Productivity, mitigations, perfromances, industry, value etc.
Nisin Production from Waste: A Review
Authors:   Department of Biotechnology, RV College of Engineering, Bangalore, India, Kumar Dr. S Narendra
Published: August 2023

Nisin is a bacteriocin produced by microbial fermentation of the well-known starter culture for dairy products, Lactococcus lactis. A major challenge in food safety and security is the prevention of the emergence of unwanted microbes. Artificial preservatives added to prolong the shelf life of foods may have negative effects on consumer health. An alternative approach is to use bio-preservatives. However, the cost of production of nisin is relatively higher than other chemical-based alternatives, because of which it has low marketability. Traditional production techniques are expensive and harmful to the environment. This review investigates sustainable alternatives employing waste products as fermentation substrates, including whey, corn stover, cane molasses, soya-bean cake, bean pulp and mussel processing waste. These eco-friendly strategies minimize negative environmental effects while providing resource and cost-efficient solutions. This review demonstrates the possibility for India to become self-sufficient in nisin production and reduce reliance on imports by emphasizing waste-to-value techniques. Keywords: Nisin, Bio-preservatives, Waste-to-value, Sustainable, Eco-friendly
Privacy Concerns in Document Sharing: “A Study on Indian Photocopy Shops and Cyber Centers"
Authors: Chhajed Manthan P
Published: August 2023

In the context of India's document printing practices, this research paper sheds light on the existing shortfalls in privacy and security. Despite the prevalence of digital sharing, conventional methods such as email and messaging platforms continue to be widely used, putting sensitive documents at risk of unauthorized access, data breaches, and potential misuse. This paper aims to address these concerns by proposing a practical approach tailored to the unique needs of photocopy making shops and cyber centers. By focusing on enhancing privacy and security measures, the proposed approach aims to empower individuals and organizations with greater control over their sensitive documents. The research delves into the pressing concerns surrounding document handling in these environments and explores ways to ensure data protection while utilizing modern document printing and sharing technologies. Through this timely endeavor, the aim is to create a safer and more secure ecosystem for document management in India's photocopy making shops and cyber centers. Keywords: Document printing, Privacy, Security, Data breaches, Misuse, Photocopy making shops, Cyber centers, Document handling, Data protection, Modern document printing, Sharing technologies, Safer ecosystem.
Advancements in Polyhydroxyalkanoates (PHA) Production via Fermentation
Authors: JOURNAL IJSREM
Published: August 2023

Polyhydroxyalkanoates (PHA) have emerged as promising biopolymers due to their biodegradability and potential to replace conventional plastics. This review paper provides an overview of PHA production through fermentation, with a specific focus on utilizing whey as a cost-effective substrate. The paper highlights the importance of microorganism selection, whey pre-treatment requirements, recycling waste streams, PHA purification techniques, and the influence of PHA monomer composition on product properties. By addressing these key aspects, this review aims to contribute to the development of economically viable and environmentally friendly PHA production processes
A Study Performance of Conventional Structure and Outrigger Structure with Dampers in Seismic Zone IV and V
Authors: GOWDA SD VINEETH
Published: August 2023

This study compares the seismic performance of a conventional high-rise building, designed following standard codes, with an outrigger structural system featuring additional lateral resisting elements like outriggers and friction dampers. The aim is to assess the effectiveness of the outrigger system in reducing seismic forces in high seismic zone IV, zone V and enhancing overall building performance. Through seismic analysis using ETABS and comparing in storey displacement results. The findings will offer valuable insights to aid engineers in making informed decisions for seismic-prone regions, leading to safer and more resilient high-rise structures. Key Words: conventional structure, outrigger structure, friction dampers, static and dynamic analysis (Response spectrum method)
A STUDY ON COMPARATIVE STUDYON FLAT SLAB STRUCTURE WITH AND WITHOUT SHEAR WALL
Authors: R Mahesh Babu
Published: August 2023

This study presents a detailed comparative analysis of flat slab structures with and without shear walls to evaluate their seismic performance, structural behavior, and overall efficiency. Flat slab structures are widely used in modern construction due to their simplified formwork and enhanced architectural flexibility. However, their seismic performance has been a subject of concern, especially in regions prone to seismic activity. This research involved numerical simulations and analytical investigations to explore the behavior of flat slab structures under seismic loads. In this work, two main factors were considered namely with shear walls and without shear walls for flat slab structure. The Structure is modelled with the ETABS software and analysis according to 1893:2002. The project work is carried out for (G+10) stories of structure and analysis for different models, Flat slab with shear and without shear partitions. Based on the assessment of various parameters, it was observed that the flat slab with shear partition exhibited decreased values of story displacement and drift, along with improved values of story stiffness and shear when compared to the flat slab with shear wall system. Key Words: Flat Slab, Shear Wall, Seismic Loads and E-TABS.
An Information Architect by Any Other Name
Authors: Reiss Eric
Published: August 2023

The mere fact that you are reading this Journal tells me you’re different. You will inherit the earth. Not because you are meek, but because you recognize the importance of information architecture.
to_be_classified: A Facet Analysis of a Folksonomy
Authors: Conradi Elise
Published: August 2023

This paper examines the use of the postulational approach to facet analysis to manually induce a faceted classification ontology from a folksonomy. An in-depth study of faceted classification theory is used to form a methodology based on the postulational approach, which is then used to facet analyze a dataset consisting of over 107,000 instances of 1,275 unique tags representing 76 popular non-fiction history books collected from the LibraryThing folksonomy
Building an Information Architecture Checklist: Encouraging and Enabling IA from Infrastructure to the User Interface Architecture
Authors: Downey Laura , Banerjee Sumit
Published: August 2023

Government environments often have prescribed complex processes for obtaining and implementing technology solutions. In order to encourage and enable information architecture (IA) in government systems, it is essential to embed IA within the current processes and to view IA as part of the overall architectural framework. The definition of IA used here is broad and inclusive spanning applications, the Web and the enterprise. A common focus exists aimed at organizing information for findability, manageability and usefulness, but the definition also includes infrastructure to support organization of information. This case study describes the development of an IA checklist in a large United States government agency. The checklist is part of an architectural review process that is applied 1) during assessment of proposed information systems projects and 2) design of solution recommendations before system implementation
Classification, Facets, and Metaproperties
Authors: Frické Martin
Published: August 2023

The paper argues that second order properties or metaproperties are essential for classification and navigation of information, for example for faceted classification and the navigation it generates. The paper observes that metaproperties, are not accommodated well within such standard schemes as Z3.1, description logics (DLs), and the formal ontologies OWL, BFO, and DOLCE
Information Architecture is a Way of Seeing
Authors: Klyn Dan
Published: August 2023

In the Midwest of the USA where I live, there is a thinly-veiled disdain among Medical Doctors for “Doctors” of Chiropractic. Depending on which generation of MD or DC you consult with, you’ll hear different arguments for why one or the other approach is better. In my personal experience with lower back pain this past Spring, the severity of the malady — and not the weight of the opposing arguments — dictated my immediate course of action: I was unable to walk, weeping from pain and in need of narcotic pain killers. Immediately. And they don’t give prescription pads to DC’s
Web Information Architecture: A Very Inclusive Practice
Authors: Burford Sally
Published: August 2023

Information architecture is a critical aspect of the organizational use of the Web to deliver information and to communicate with clients. It is a relatively new instance of information organization and, although it draws from traditional practices such as library and information science, Web information architecture has its own characteristics and unique contexts. The practice of Web information architecture must forge its own identity. This research paper contributes to a greater understanding of Web information architecture as a practice that requires myriad conversations, negotiations and collaborations as it is carried out in large organizations. It is also a practice that is undertaken by multiple and diverse people who all make a contribution to the information structures of the enterprise website
Architectures
Authors: Arango Jorge
Published: August 2023

The end product of information architecture can be many different things: a website, a movie, a book, a game such as chess, the location of products in supermarkets. Indeed, as more of these cultural artifacts become digital, their purely informational nature is becoming more prominent
Efectos secundarios de la inmunoterapia aplicados en pacientes pediátricos con tumores cerebrales
Authors: Torres Condori Meliza Milagros
Published: August 2023

La inmunoterapia es una modalidad de tratamiento prometedora para los tumores cerebrales pediátricos, es importante tener en cuenta que los medicamentos utilizados pueden ocasionar efectos secundarios que pueden afectar cualquier órgano del cuerpo o poner en riesgo la salud de los pacientes. Por lo tanto, es crucial vigilar y reconocer tempranamente los síntomas, evitando así la exacerbación de estos problemas, ya que los efectos secundarios de la inmunoterapia pueden variar desde leves y moderados hasta potencialmente mortales.
Thirdhand smoke exposure and its toxicological impacts: A review on target organ based studies
Authors: KOLCİ Kübra , GARİPKUŞ Sena Nur , REİS Rengin
Published: August 2023

Third-hand smoke (THS) is a newly described environmental health hazard that might be defined as a residual cigarette smoke that occurs due to the accumulation of toxins of second-hand smoke (SHS) in the smoking environment. In addition, chemicodynamic of THS may alter due to the interaction with other gases and chemicals present in the environment. THS may cause serious health outcomes in the lungs, liver, skin, heart, and nervous system as well. Hence, it is thought to represent a major health hazard for people, particularly for children, whom exposed to THS where they interact more frequently with these surfaces exposed to THS via hand to mouth transfer. In the present study, it was aimed to summarize the proposed toxicity mechanisms based on in vitro and in vivo studies based on target organ toxicity. In this study, it is aimed to review toxicity mechanisms of THS based on in vitro and in vivo studies on target organ toxicity. Recent studies reported that THS might induce unwanted effects in the respiratory, cardiovascular, nervous, hematopoietic, and skeletal systems and skin. Literature data indicated that THS-mediated oxidative damage and increase in inflammatory response may play an important role in the pathogenesis of cardiovascular and neurobehavioral diseases, especially the target organ lung, and in the future, THS might be defined as a preventable environmental risk factor. Therefore, further studies on THS are needed to define its toxicity mechanism as well as increase the social awareness and legal regulations.
The Effect of Troxerutin Consumption on the Symptoms of Morphine Withdrawal Syndrome in Male Mice
Authors: GHASEMİ SHAYAN Ramin , HOSSEİNZAD MANİE Nasrin
Published: August 2023

Introduction: Chronic morphine use is associated with increased oxidative stress and inflammatory factors. Troxerutin is a natural bioflavonoid and has antioxidant and anti-inflammatory effects that could relieve morphine withdrawal syndrome.

Aim: The effects of troxerutin on morphine dependence in mice

Method: Troxerutin was prepared in three different doses (50, 100, and 200 mg/kg) via a normal saline solution. After examining the composition of troxerutin, the experiment was performed in five groups of 8 mice. One group received eight days of increasing doses (10, 20, 30, 40, 50, and 60 mg/kg) of morphine SC (subcutaneously) with normal saline (10 ml/kg) IP (Intraperitoneal), and one group received only normal saline and the other three groups received three different doses of troxerutin solved in normal saline as the carrier of troxerutin along with morphine. On the ninth day, withdrawal symptoms were recorded after naloxone injection and blood samples were examined for antioxidant factors.

Results: The total withdrawal score in the 50 mg/kg dose of the troxerutin group with morphine was significantly lower than the morphine-saline group (p
Interaction of Statins with Grapefruit Juice
Authors: ATEŞ Müge , ŞAHİN Selma
Published: August 2023

Grapefruit juice, which discovered to interact with felodipine for the first time, is now known to interact with more that 80 drugs. Statins are among the drugs that interact with grapefruit juice. Grapefruit juice-statin interactions were first investigated in 1998 in human pharmacokinetic studies with lovastatin and simvastatin. The pharmacokinetic and pharmacodynamic basis of the interaction has been extensively investigated in studies. Flavonoids and furanocoumarins, the main components of grapefruit juice, have been reported to cause drug interactions. Furthermore, statin-grapefruit juice interactions occur mostly through inhibition of cytochrome-3A4 (CYP3A4), to a lesser extent through inhibition of P-glycoprotein (P-gp) and organic anion transporting polypeptides (OATPs). Changes in plasma drug levels as a result of interaction may increase the side-effect of statins or reduce their therapeutic efficacy. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption.
The Role of Radiopharmaceuticals in the Bone Metastases Therapy
Authors: BATTAL Hümeyra , ERDOĞAN Suna
Published: August 2023

Cancer, having quite high morbidity and mortality rates, has become a significant public health problem in recent years, and it is the second leading cause of death after heart disease in the world. Metastases are one of the most serious complications of cancer, and bone metastases are detected in 2/3 of metastatic cancer cases. General therapy approaches in bone metastases can be classified as surgery, bisphosphonates therapy, radiotherapy, and radionuclide therapy. Radionuclide therapy using alpha and beta emitting radionuclides is more selective and effective than other local and systemic treatment methods, and this feature provide several advantages over existing therapeutic methods. Radionuclide therapy used in bone metastasis for reducing the pain, killing tumor cells, prolonging life span, and improving quality of life.

In recent years, alpha-emitting radiopharmaceuticals [such as Radium-223 (Ra-223) chloride] and beta-emitting radiopharmaceuticals [such as Strontium-89 (Sr-89) chloride, Lutetium-177 (Lu-177) labeled Ethylenediamine Tetra Methylene Phosphonic Acid (EDTMP), Samarium-153 (Sm-153) labeled EDTMP] are introduced in the clinic for especially the treatment of painful bone metastases and on the other hand new radiopharmaceutical development studies also continue intensively, like Actinium-225 labeled prostate-specific membrane antigen-617 (Ac-225-PSMA). Many studies have proven that using radiopharmaceuticals in the therapy of bone metastases improves the patient's general health, reduces pain and the risk of pathological fractures, and increases survival.

This review presents an overview of radionuclide therapy used in bone metastases. In this context, general information about the radiopharmaceuticals is given, and the importance of the use of radiopharmaceuticals in bone metastases therapy is explained with experimental and clinical studies examples.
The Potency of Beligo Seeds (Benincasa hispida (Thunb.) Cogn.) as Antihyperlipidemic in L-NAME-induced Hyperlipidemic Rats
Authors: ALIM Nur
Published: August 2023

Beligo or Bligo is the name of Benincasa hispida (Thunb.) Cogn. in Indonesian, is empirically used in the treatment of cholesterol and hypertension. The part of the plant used is the seed. This have a look at aimed to determine the antihyperlipidemic activity of beligo seeds in L-NAME-induced hyperlipidemic rats. Male albino rats (n= 25) were divided into 5 groups: Sod. CMC 1%, plant extract (100 mg/kg, 200 mg/kg, 300 mg/kg body weight), and Simvastatin were induced by L-NAME 40 mg/kg BW for 4 weeks. Measurement of lipid profile levels consisting of TC, HDL, LDL, TG, and VLDL, using a human analyzer (Thermo Scientific Indico®). L-NAME was shown to significantly (p
An Ethnomedicine Study of Traditional Healers as Joint Pain Therapy in Bantul District, Yogyakarta
Authors: WIDYOWATI Retno , PURWITASARI Neny , EKASARI Wiwied , AGİL Mangestuti , SAHU Ram Kumar , AROSA Zalza Billa , SHOLİKHAH Irawati
Published: August 2023

Joint pain is a sign of disorders of the musculoskeletal system. In joint pain, there will usually be discomfort in the joints, swelling, inflammation, and stiffness that can cause movement restrictions. Bantul is the district with the lowest prevalence of joint disease in Yogyakarta. The low prevalence of joint disease can be related to the culture of the community in using traditional herbs to treat the disease. The purpose of this study was to analyze the types of plants used in making potions to treat joint pain complaints, find out how to process the plants used, and know how to use herbs to treat joint pain. Traditional knowledge about local and native plants used was collected by field surveys. 48 healers from 3 hamlets in Bantul District, Yogyakarta were obtained by snowball sampling technique. An amount of 47 herbal potions were recorded as being applied for joint pain treatment. They used 33 plants relating to 18 families and the highest-used family was Zingiberaceae. Raw materials are processed by washing, boiling, pounding, grinding, pulverizing, and squeezing. There are two ways of using herbs to treat joint pain using the traditional herbs orally and topically (compresses). This study shows that most of the people in the Bantul District still depend on medicinal plants to treat diseases. Nevertheless, there are only a few traditional healers, there is a great danger that traditional knowledge will soon be lost because the young generation is not concerned about continuing this custom.
Antibiofilm Effect of Moringa oleifera Leaf Extract Against Staphylococcus aureus, Cytotoxicity, Biochemical aspects, Anti-Inflammatory potential, and Interference on the Activity of Antimicrobial Drugs
Authors: KİMBERLY SİLVA ALCÂNTARA Lorena , CARREİRO MACHADO Luiz Felipe , PENNA CERAVOLO Isabela , MARTİNS Renan , DİAS SOUZA Marcus Vinícius
Published: August 2023

Abstract: There is a growing technical difficulty to treat infectious diseases due to molecular mechanisms of resistance to antimicrobial drugs, such as biofilm formation. Here we provide evidence of the antimicrobial potential of the hydroethanolic extract of Moringa oleifera leaves, traditionally used to treat disorders like cardiovascular and endocrine diseases, on clinical isolates of Staphylococcus aureus. The extract was chemically characterized using classic techniques and by ultra performance liquid chromatography (UPLC). We carried out minimum inhibitory concentration tests, as well as minimal bactericidal concentration and minimal biofilm eradication concentration tests. Moreover, we tested the anti-inflammatory potential and assessed the toxicity of the extract on buffalo green monkey (BGM) cells. We also investigated the effects of combining the extract to clinically relevant antimicrobial drugs (i.e., synergistic or antagonistic interactions). The extract was active at 8 g/mL and 16 g/mL for planktonic cells and biofilms, respectively. Its anti-inflammatory potential was confirmed, and it lacked cytotoxicity. No significant interference of the extract on antimicrobial drugs was observed. Flavonoids, tannins, proteins, carbohydrates and vitamin C were detected in the extract. Our data open doors for further studies with isolated molecules of the extract in order to conduct in vivo antimicrobial tests.
Validation of RP-HPLC UV method for determination ketoconazole in rabbit plasma: An application to the pharmacokinetic study
Authors: ANNİSA Viviane , SULAİMAN Teuku Nanda Syaifullah , NUGROHO Akhmad Kharis , NUGROHO Agung Endro
Published: August 2023

Ketoconazole is an imidazole broad-spectrum antifungal agent used for systemic and local infections. The pharmacokinetic information for ketoconazole is relatively limited. The validated method for determining ketoconazole in plasma rabbit is not yet reported. The HPLC-UV method is simple, rapid, cost-effective, sensitive, and only requires a small blood sampling. The chromatographic system consisted of a reversed-phase C18 column (250 x 4.6 mm, 5 µm) at a flow rate of 1 ml/min and detection wavelength of 240 nm, and the retention time of about 5 minutes for ketoconazole and 11 min for itraconazole as internal standard. The calibration curve presented linearity in the 0.05-8 µg/ml with R2=0.9969, which indicated good linearity. The method's precision was obtained by intra-day and inter-day repeatability studies, and accuracy was examined by %diff. The result is
Toxicological Evaluations of Smilax Myosotiflora Methanol Extract and its Effect to Testosterone Level of Male in Subacute Study
Authors: ROSDİ Rasmaizatul Akma , SUL'AİN Mohd Dasuki , DARNİS Deny Susanti , BAHARUN Nur Bazlını , AHMAD Nur Fatıhah , WAN ISHAK Wan Rosli
Published: August 2023

Smilax myosotiflora A. DC., the horny little devil, is a tropical creeping plant which popularly consumed as a male aphrodisiac, energy booster and lumbago reliever in the old traditional medicinal. The scientific studies showed that the plant able to increase sexual behaviors and testosterone level in male rats. However, its toxicity effect is still remained unknown. Therefore, this study aimed to investigate the toxicity effects of S. myosotiflora methanol extract (SMME) through in vitro and in vivo studies. The SMME was subjected to the brine shrimp lethality test (BSLT) to determine the LC50. Acute and subacute toxicity studies according to the Limit Test of OECD guidelines no. 425 and 407 was carried out through oral gavage accordingly. It was found that the LC50 of SMME was 674.4ppm while its LD50 via acute test was more than 5000mg/kg. Neither sign of toxicity nor significant difference in food intake, weight gain, gross necropsy, the hematological and biochemical analyses and histological evaluations were recorded between the control and treated groups except for the level of AST and testosterone in male and sodium and triglycerides in female rats. The increase of testosterone in male might occur through specific pathway as the SMME did not increase the hormone level in the female. According to GHS classification, SMME in this study can be classified as Category 5 (Safe) and non-toxic. Data from this study can be served as a primary predictive guide for future research in assessing the efficiency and safety of S. myosotiflora consumption for human trial.
Evaluation of Mechanical and Mucoadhesive Properties of Polyvinyl Alcohol Nanofibers As Vaginal Drug Delivery System
Authors: SAAR Sinem , TUĞCU DEMİRÖZ Fatma Nur
Published: August 2023

Electrospinning is a versatile and inexpensive technique to produce nanofibers. Nanofibers can be a good alternative to classical dosage forms in vaginal applications due to high surface area/volume ratio, high encapsulation efficenciacy and mucoadhesive properties. Polyvinyl alcohol (PVA) is a biocompatible, easily degradable and flexible polymer with mucoadhesive properties used in industrial, commercial and medical applications. The scope of this study is to characterize electropsun nanofibers produced with different PVA types for vaginal use. PVA nanofibers were produced using the electrospinning method. Nanofiber formulations were prepared by dissolving PVA in dimethylformamide (DMF):distilled water (1:1) solvent system. Nanofibers were produced with three different types (PVA M 13/140, PVA G 26/140 and PVA G 40/140) PVA at 5%, 7.5% and 10% concentrations. The surface tension, viscosity and conductivity properties of the polymer mixtures were measured for electrospinning process and these parametres were found suitable for nanofiber production. While the viscosity increased with increasing polymer concentration, the surface tension values were found to be close to each other since the solvent system was the same. The mechanical and the mucoadhesive properties of nanofibers were examined and compared. Mucoadhesive and mechanical properties of nanofiber formulations differed depending on molecular weight and electrospinning process. The nanofiber formulations produced with PVA M 13/140 were found suitable for vaginal applications in terms of their mechanical and mucoadhesive properties. PVA nanofibers can be a good alternative as a drug delivery system in vaginal applications.
Determination of Biological Activities of Salvia sclarea L.
Authors: YÜCEL Yasemin Yücel , ÖZDEMİR Ebru
Published: August 2023

Within the last two or three decades the treatment of the neurodegenerative disorders became became the main focus of the researches. In this, our aim was to determine some biological activities of the ethanolic and methanolic extracts of Salvia sclarea L. After obtaining the extracts, first they have been tested for their DPPH radical scavenging activity and then the total phenolic contents of the extracts have been identified. Afterwords, the extracts were evaluated for both their effects on acetylcholinesterase (AChE) and monoamine oxidase-A. These two enzymes are very important enyzmes for their importance in the treatment of neurodegenerative disorders. AChE plays a very crucial role especially in Alzheimer’s Disease. Monoamine oxidases and their inhibitors have also critical value in Alzheimer type dementia and in other neurologic diseases. It has been found that DPPH activity of the methanolic extract was higher than that of ethanolic extracts; while TPC was higher for the ethanolic extract. IC50 values were found for both AChE and MAO-A. For AChE the IC50 values for ethanolic extract and methanolic extract were, 0,27±0,005 mg/mL and 1,19±0,037 mg/mL; respectively. And for MAO-A the IC50 values for ethanolic extract and methanolic extract were 6,53±0,72 microgramg/mL and 3,03±0,05 microgram/mL; respectively.
Does Foreign Direct Investment Reduce Growth Government Debt?
Authors: Dina Hendiyani  , Zainuddin Iba
Published: August 2023

The problem of fiscal deficits in the Indonesian economy has prompted the government to increase debt as a solution to reduce the deficit. Debt withdrawal in the long term without the support of an increase in state revenues has had a negative impact. Government debt increased sharply. Efforts to increase state revenue through tax collection in post-Covid 19 economic conditions that have not yet recovered will only reduce economic activity. This requires efforts to suppress government debt growth amidst a fiscal deficit. This study aims to analyze the effect of foreign direct investment, inflation and the exchange rate on government debt. Foreign direct investment is believed to be a source of financing that cannot be made through state revenue. Especially public infrastructure financing. The study concluded that it was found: foreign direct investment, inflation, and the exchange rate had a significant effect on government debt. Thus, government efforts are needed to encourage the growth of foreign direct investment, through policies that are oriented towards increasing foreign direct investment.
Terms and Conditions Applicability Muamalat
Authors: Rahmat  , Asmuni  , Tuti Anggraini  , Ade Khadijatul Z. Hrp
Published: August 2023

Aspect this elaborate agreement with the free, prohibition of usury and avoidance gharar, avoidance qimar and maisir, as well as suitability contract with maqashid sharia All studies This concludes that arrangement contracts are very important for efficacy, Muamalat, and ensuring obedience to internal sharia principles in transaction finance. Method This collects data through related literature, with agreement from Muamalat, like books, journals, and scientific articles. Research results this is a) Consent with the free method agreement That made for fulfillment the will of the parties in agreement, and it is compatibility between them to fulfill obligations with those shown with imitation, writing, moving hand, or act. b) Prohibition of usury and avoidance gharar is a prohibition to protect treasure from loss and the loss of enmity arising in people from this type of sale. c) Avoidance Qimar and Maisir is a game that has gains and losses for perpetrators of crime. d) A compatibility contract with Maqashid Syari'ah is a contract. No one can be opposed to the general public's interest.
Study of the Role of Social-Media on Consumer Desire to Shop in E-Commerce
Authors: Rudy Irwansyah  , Supiah Ningsih
Published: August 2023

Social media now has a very important role in people's lives. Social media has a function as a tool for interacting and socializing between one individual and another. And this can be done online, which gives humans the possibility to interact without space and time limitations. Social media has a very important role in the economic industry. Especially in shopping in e-commerce. This research was conducted to find out how much influence social media has on consumers' decisions to buy the goods they want. This research method by analyzing data from methods such as questionnaires, observation and also literature study. Besides that, the quantitative method is the method used in this research. Testing the validity, reliability and also the coefficients is one way of analyzing the data obtained to see the influence of social media on consumer decisions. There is a significant influence exerted by social media on consumers' desire to shop at E-Commerce.
The Effect of Digitizing Library Services and Facilities on User Satisfaction
Authors: Mutawali Amad , Alamsyah Sakti , Saputra Unin Nibi
Published: August 2023

Digitization of library services and facilities is a factor that can increase user satisfaction. The purpose of this study is to determine the effect of digitization of library services and facilities on user satisfaction. This research data is from users at the Regional Library of Cianjur Regency with a population of 1,000. The sampling technique in this study used a sample size web.raosoft.com with an error rate of 5% so that a sample of 287 respondents was obtained. Disseminating questionnaires is a method of data collection. This study used multiple linear regression analysis as its analysis method. The results showed that the digitalization of library services and facilities had a positive effect on user satisfaction, and the effect was 38.8% while 61.2% was influenced by other variables. The variable that has a dominant influence is library facilities, with an influence of 16%. The contribution of this study is to expand marketing management literature related to the digitization of library services and facilities in the context of organizations.
Transformational Leadership Style of Principals in Primary Schools
Authors: Yuda Mulfi Sandi , Rachmawati Ike , Sugihartto Sugihartto
Published: August 2023

The purpose of this study aims to analyze the transformational leadership style applied by the Principal, in elementary schools in Sukalarang District, Sukabumi Regency, West Java. Leadership Style is focused on charismatic leadership, inspirational motivation, intellectual stimulation, and individual consideration. The data collection technique is carried out through observation, interviews, and documentation. The research location focused on Sukalarang District, Sukabumi Regency, West Java. The informants in this study were school principals, teachers, and education staff as many as 15 people. Data analysis is carried out by selecting answers obtained from informants and then collected for analysis and conclusions. The data analysis used is data triangulation. The results of the study were obtained, 1) charismatic leadership from the principal, namely every democratic decision-making with educators, and the principal as an actor in carrying out transformational leadership takes a deliberation approach (open management) to make a decision. 2) Inspirational motivation from the principal is shown by Building the will to achieve achievements and planting building a positive organizational culture and organizational climate without discrimination. 3) Intellectual stimulation including the principal creates a positive work culture by strengthening human relations between educators formed through teamwork skills, communication, and the same view on the vision and mission. 4) individual consideration, namely the principal's concern in developing the character and performance of educators through various pieces of training such as independent curriculum training, scientific papers, Teacher Professional Education, and independent teaching Platform (PMM), as well as the Principal gave appreciation to educators for their achievements.
The Influence of Profitability, Liquidity and Tax Avoidance on Firm Value (Case Study in Stock Exchange Mining Sector Companies Indonesia Period 2019 - 2021)
Authors: Latersia Br Gurusinga  , Natasya Lovett Michelle
Published: August 2023

This study aims to examine and analyze the effect of Profitability, Liquidity, and Tax Avoidance on the Company Value of Mining Sector Companies listed on the Indonesia Stock Exchange in 2019-2021. The research methodology used is a quantitative descriptive method. In this study, the population used is all mining listed on the Indonesia Stock Exchange from 2019 to 2021 with a total of 28 companies. Sampling Using the purposive sampling method, namely the technique of determining the sample with certain considerations and obtaining as many as 72 research samples from 24 companies. The results of the research analysis shexamines and analysesow that profitability has a tcount (3.003) > ttable (1.995) with a significant level of 0.004 <0.05 so it can be concluded that profitability has a positive and significant effect on firm value. Liquidity has a value of -tcount (-2.023) < -ttable (1.995) with a significant level of 0.047 <0.05 so it can be concluded that Liquidity has a negative and significant effect on Firm Value. Tax Avoidance has a value of -tcount (-0.327) > -ttable (-1.995) with a significant level of 0.745 > 0.05 so that it can be concluded that Tax Avoidance has a negative and not significant effect on firm Value. Profitability, Liquidity, and Tax Avoidance have a value of Fcount (4.435) < Ftable (3.13) with a significance of 0.007 > 0.05 so it can be concluded that simultaneously the variables Profitability, Liquidity and Tax Avoidance have a positive and significant effect on Firm Value.
The Effect of Electronic Word of Mouth (E-WOM) and Price Perception on Purchase Decisions of MIXUE Products in the City of Surabaya
Authors: Luthfi Ali Akbar  , Ugy Soebiantoro  , Egan Evanzha Yudha Amriel
Published: August 2023

This study aims to determine the effect of E-WOM on Mixue Products in Surabaya and the influence of Price perceptions on Purchase Decisions of Mixue Products in Surabaya. The population in this study are consumers of Mixue products in Surabaya. The sample in this study used the slovin formula and found the results of 100 respondents. The method used in this study uses the GForm form. The analysis technique in this study uses PLS (Partial Least Square). The results of this study indicate that the E-WOM indicator variable that has the highest percentage is I often collect review information from consumers online before I buy Mixue products (X1). From the results of the study, it can be concluded that E-WOM contributes to Mixue Purchase Decisions in the City of Surabaya. The more intensity and reviews that mention Mixue products can encourage purchasing decisions about what Mixue Surabaya has provided.