bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of fatal and non-fatal cardiovascular events in men aged 25-44 in the city of Novosibirsk. Cohort study
Authors: Stryukova E. V. , Shcherbakova L. V. , Gafarov V. V. , Rymar O. D. , Khudyakova A. D. , Evdokimova N. E. , Ragino Yu. I.
Published: February 2023

Aim. To study the incidence and risk factors of cardiovascular events (CVEs) during an 8-year follow-up of a cohort of men aged 25-44 years (Novosibirsk).

Material and methods. The cohort study included 1415 people aged 37,33 [31,83; 41,92] years (Median, Me [interquartile range, Q25; Q75], of which 670 (47,3%) were men. Median follow-up period was 6,9 [5,8; 7,8] years. CVEs were identified using the "Registry of Acute Myocardial Infarction", fatal cases — from the "Medical Certificates of Cause of Death". The examination program included a questionnaire, anthropometry, biochemical studies. Statistical processing was carried out using SPSS (version 13.0).

Results. Thirteen CVEs were identified, of which 6 were fatal. Survival prognosis was more favorable in men without hypertension, with a heart rate (HR) <80 bpm. The risk of CVEs increased by 14% with an increase in fasting plasma glucose by 0,5 mmol/l, by 1,8 times with creatinine increase by 10 pmol/l (decreased by 29% with an increase in glomerular filtration rate by 5 ml/min /1,73 m2); 2 times with a heart rate increase by 10 bpm, regardless of other cardiometabolic risk factors.

Conclusion. Significant risk factors for fatal and non-fatal CVEs in men aged 25-44 years are hypertension, heart rate >80 bpm, increased fasting plasma glucose, creatinine levels (or decreased glomerular filtration rate).
Significance of standard and speckle-tracking echocardiography for early diagnosis of asymptomatic left ventricular dysfunction in type 2 diabetes
Authors: Utina T. G. , Akasheva D. U. , Korsunsky D. V. , Drapkina O. M.
Published: February 2023

Aim. To study the relationship between echocardiographic parameters of left ventricular (LV) function and carbohydrate metabolism indicators, as well as to evaluate value of speckle-tracking echocardiography (STE) in the early diagnosis of subclinical LV dysfunction in type 2 diabetes (T2D) in individuals without clinical manifestations of cardiovascular disease (CVD).

Material and methods. The study included 120 people of both sexes aged 45 to 75 years. Patients were divided into three following groups: 1 — with T2D (n=53), 2 — with prediabetes (n=20), 3 — control, without carbohydrate metabolism disorders (n=47). All participants underwent transthoracic two-dimensional echocardiography with an assessment of standard systolic and diastolic parameters, as well as quantitative STE indicators. In addition, all participants underwent laboratory diagnostics of carbohydrate metabolism disorders, which included the determination of blood fasting glucose, glycated hemoglobin (HbA1c), insulin, and C-peptide, as well as insulin resistance index estimation.

Results. In patients with T2D, in comparison with the control group, diastolic function parameters were significantly different as follows: a lower value of early to late diastolic transmitral flow velocity (E/A) ratio, the ratio of early transmitral flow velocity to early diastolic mitral annulus velocity (E/e'), mitral annular velocity (e') and higher isovolumic relaxation time (IVRT), as well as early diastolic flow deceleration time (DT). According to multivariate analysis, not only T2D, but also prediabetes was an independent predictor of diastolic dysfunction. The Simpson's LV ejection fraction was preserved in all study participants. In patients with T2D, in comparison with the control, according to STE, a decrease in global longitudinal strain (GLS), an increase in apical rotation, and also LV twist were revealed. In a multivariate regression analysis, the HbA1c level had an inverse relationship with GLS and was an independent predictor of its decrease, and the T2D duration was a significant predictor of twisting changes, apical and basal rotation. At the same time, GLS and LV twist had a high sensitivity in determining the decrease in E/A, e'/a', e', as well as the increase in IVRT.

Conclusion. In patients with T2D without CVD manifestations, sub-clinical signs of diastolic dysfunction were revealed, such as delayed LV relaxation; systolic dysfunction with preserved ejection fraction was manifested by a decrease in GLS, as well as an increase in apical rotation and LV twisting, identified by STE. The severity of asymptomatic LV systolic-diastolic dysfunction was associated with the severity of glucose metabolism disorders and T2D duration.
Ultrasound-assisted examination in internal medicine practice
Authors: Drapkina O. M. , Dzhioeva O. N. , Balakhonova T. V. , Safarova A. F. , Ershova A. I. , Zorya O. T. , Pisaryuk A. S. , Kobalava Zh. D.
Published: February 2023

The guidelines have been developed for internists, general practitioners, emergency physicians, and paramedics. The guidelines are based on expert consensus papers, accumulated clinical and scientific experience. The methodology for organizing and conducting ultrasound-assisted examinations is described in detail. Algorithms for diagnosing the main syndromes in internal medicine practice are presented to help the practitioner. Particular attention is paid to the methodology of ultrasoundassisted examinations. These guidelines will be of interest to doctors, heads of medical facilities, as well as students of medical universities.
EVALUATION OF DISSIPATION ENERGY OF ISOTROPIC CONTINUUM DAMAGE MECHANICS MODEL WITH ADAPTIVE TIME-STEP CONTROL APPROACH
Authors: Liu Nianqi , Yuan Zifeng
Published: February 2023

This paper proposes an algorithm to evaluate dissipation energy of an isotropic continuum damage mechanics model with an adaptive time-step control approach. The algorithm takes place at each integration point under the scope of finite element analysis. The total amount of the dissipation energy of one structure can be used to verify the conservation law of energy, where the summation of the elastic strain energy and the dissipation energy should be equal to the total work by external force. However, the paper shows that this condition may not be valid when the unstable crack propagation occurs. When the crack propagation is unstable, the development of damage can be driven by stored strain energy without external load. The strains at the beginning and ending time within one increment at the damaged elements will give inaccurate dissipation energy by the classic trapezoidal integration scheme. In addition, this paper proposes a new damage evolution shape function with C1 continuity of the strain-stress curve under the uniaxial tension test, which is used to demonstrate the numerical procedure of the adaptive algorithm.
A Katonai Egységes Felhőalapú Eszközrendszer fogalmi rendszerének meghatározása
Authors: Tóth András
Published: February 2023

Napjaink katonai műveleteiben kiemelt szerepet kapnak a harctéri érzékelő rendszerek, valamint a felderítést, megfigyelést támogató különböző megoldások. Ezek felhőalapúösszekapcsolásának lehetősége hozzájárulhat a nagymennyiségű információ közel valós idejű, folyamatos megosztásához. A tanulmány célja a Katonai Egységes Felhőalapú Eszközrendszer fogalmának meghatározása. Ennek eléréséhez a szerzőösszehasonlító elemzést végzett a témában megjelent releváns nemzetközi tudományospublikációk és szakmai jelentések vonatkozásában, amelyek alapján megfogalmazta kutatási eredményeit.
Izraeli válaszok napjaink kibervédelmi és kiberhadviselési kihívásaira
Authors: Rémai Dániel
Published: February 2023

A kiberbiztonság és a kibervédelem napjainkban megkerülhetetlen tényezők, ha egyország általános biztonságát vizsgáljuk. A tanulmány Izrael Állam vonatkozásábantekinti át a kiberbiztonság és a kibervédelem fogalmának megjelenését, változását ésennek hatását a zsidó állam nemzeti biztonsági koncepciójára. Vizsgálja továbbá akapcsolódó intézményi struktúrát, fókuszálva a nemzetbiztonsági szolgálatok szerepéreés megváltozott feladataira.A kiberstratégia és az operatív feladatvégrehajtás a kibertérben Izrael esetében pontosanolyan, mint számos egyéb szektor az országban: egyszerre kaotikus, ugyanakkorhatékony. Az Izrael által, az elmúlt negyed évszázadban a kibervédelem és kiberhadviselésterén bejárt út példaértékű, ugyanakkor megismételhetetlen. Elemzésemennek az útnak a bemutatására vállalkozik.
A mesterséges intelligencia hatása a társadalomra
Authors: Kiss Csaba , Kollár Csaba
Published: February 2023

A mesterséges intelligencia az utóbbi tíz-tizenöt évben a tudományos diskurzusok és kutatások slágertémája lett. Megannyi tanulmány született és születik arról, hogy a mesterséges intelligencia milyen hatást gyakorol a társadalomra, ugyanakkor Magyarországon a jelen tanulmányunkban ismertetett kutatás az első, amelyik közel ezer fő bevonásával, katonai múlttal rendelkezők, illetve civil válaszadók körében több területen vizsgálja a kérdéskört. Tanulmányunk elsődleges célja a mesterséges intelligenciaemlített két célcsoportra gyakorolt hatásai közül a hasonlóságok és a markáns különbségek számbavétele.
The Battle of the Catalaunian Plains
Authors: Majorosi Ádám
Published: February 2023

In this study, I examine the „Battle of the Catalaunian Plains”. In the first part, the causes ofthe campaign of 451 are discussed; the treachery of Honoria, the Frank succession, and theOstrogotic immigrants in the Visigothic Court. Then I present the campaign, describing howthe opposite forces manoeuvred, what their plans were, and how they arrived at the place ofthe battle. The battle plans and the fight of the forces, which continued through the night, arealso analysed. Then the next couple of days, the sieges of the camps, and the reason, why theRomans left the battlefield are described. The paper is completed with the author’sconclusions, the examination of the performance of the military leaders, the losses of theopposing forces, and claiming the winner.
Public diplomacy and construction of communicational spaces. The Cuban experience
Authors: Sunamis Fabelo Concepción
Published: February 2023

Global events, such as climate change, the food crisis, or the advance of the COVID-19 pandemic, show that the world needs new integrated dynamic processes. In dealing with the pandemic, exchanges between the scientific community, trained personnel, and the training of professionals, as well as the strengthening of local capacities to deal with the health crisis, the dispatch of health material, medical personnel, etc., have been very useful.
Retroviruses: Reversing the dogma of life - A review
Authors: Shobha Potlakayala , Andrew Miles , Shrina Patel , Aayushi Patel , Gregory Wolbrette , Shriya Kane , Nicole Lookfong , Abigayle Noble , Xiuli Shen , Sairam Rudrabhatla
Published: February 2023

Retroviruses replicate by means of reverse transcription, utilizing an enzyme, reverse transcriptase, in conjunction with integrase. Their elements have been found in humans, animals, fungi, plants, and bacteria alike. For millions of years, these elements are continuing to integrate into the eukaryotic genomes and affecting these organisms to date. Specifically, endogenous retroviruses have been shown to comprise a large portion of vertebrate genomes. Studies have shown that these microscopic viral elements within the genome are influencing gene expression and in turn evolution, by affecting adjacent gene expression patterns. In the medical field, these retroviruses can present illnesses for many, such as those living with Human Immunodeficiency Virus or Human T Cell Lymphotropic Viruses. With modern advances in bioinformatics, genomics, and drug design, retroviruses are being understood much better. A multitude of new discoveries is advancing the scientific communities to mitigate, prevent, and hopefully cure serious medical ailments caused by retroviruses.
On the Development of a Module for the coupledPoroFoam Solver of the OpenFOAM Package
Authors:   South Urals Federal Research Centre of Mineralogy and Geoecology of the UB RAS, Chelyabinsk region, Miass, Ilmen reserve, 456317, Russian Federation, Chitalov D. I.
Published: February 2023

The main provisions of the process of developing a software module with a graphical component to control numerical simulation based on the coupledPoroFoam solver and its connection to the basic version of the graphical shell for the OpenFOAM application package are described. Similar applications are analyzed, the relevance of the problem is formulated. A description of the coupledPoroFoam solver and a list of its application areas are given. The process of numerical simulation of problems of continuum mechanics based on the presented solver is studied. Particular attention is paid to the definition of the goals and objectives of development, the choice of the necessary technological means. Using diagrams, the architecture of the module and the logic of its operation are described. The purpose of each component of the application and the step-by-step process of the user working with the module are given. The results of the study, provisions that determine the technical and practical significance of the work are described. Based on the created module, a numerical simulation of one of the basic problems of continuum mechanics was carried out, and the results of the experiment were presented. The achieved tasks are defined, the final conclusions about the possibility of using the selected technologies for the development of software applications are formulated.
WAYS OF SELF-ORGANIZATION OF THE POPULATION ON THE WAY TO OVERCOMING THE CRISIS OF IDENTITY
Authors:   V. I. Vernadskyi National Library of Ukraine, Matviichuk Andriі
Published: February 2023

Defined that «crisis of identity» hide in itself intention of states to separate from cultural assimilation as consequence of global world processes, dictated by the situation of uncertainty when national cultural identity can be destroyed and new identities are still clearly uncertain. Actualized S. Huntingtons position according to which when «crisis of identity comes for people, shelter and faith, religion and family are important first of all. People grouping with those who have the same roots, church, language, values and institutions and keep on the distance from those who have another». Analyzed that really this conditions today are the reasons of reborn of the patriarchal cultural identities and even fundamentalism. However, it is beware that states which in some places shows tendency to reborn of ethnocultural national identity, can risk to stand on the sides of objective globalization processes. At the same time it’s not excluded and scenario when rebirth of patriarchal identity can’t remove states from participation and while national cultural achievements stay secured. Noticed that Ukraine as a state that just has embarked on a path of it’s own independence development and immediately trapped in situation of choice of it’s own geopolitical future. In this case highlighted there is very important to realize all of essential features of global development tendencies which enhancing tendencies to blurring each national borders as in economical, political and in cultural spheres because from this depends how will look future perspective of ukrainian state existence.
Lens thickness and associated ocular biometric factors among cataract patients in tertiary hospital
Authors: Shivani Sharma  , Anil Kumar Sharma  , Satish Gupta  , Divyanshi Gupta
Published: February 2023

Background: A significant factor in determining intraocular lens power is the biometry assessment of cataract patients prior to surgery. To evaluate the distribution of lens thickness (LT) and its associations with other ocular biometric factors among cataract patients.
Methods: Total 978 eyes from cataract patients were retrospectively included. Ocular biometric factors including k1, k2, LT, central corneal thickness (CCT), anterior chamber depth (ACD), white-to-white (WTW) distance, and axial length (AL) were collected based on the medical records. The associations between LT and general or ocular factors were assessed. We analyzed the data using descriptive analysis and correlated each variable using the Spearman’s Rho analysis.
Results: The mean age was 62.5±15.70 years and 55.11% were females. Mean LT was 4.35±0.41 mm. The LT was greater in older patients. LT positively correlated with AL, WTW and CCT, while negatively correlated with ACD.
Conclusions: LT is an important biometric parameter that should be considered, along with other biometric parameters, in determining effective lens position in patients undergoing cataract surgery. ACD is predominantly influenced by LT than the AL.
Epidemiology of prediabetes and prehypertension-progression, regression and interaction
Authors: Mudasir Muzamil  , Mir Suheel Ahmad  , Ahmad Najeeb , Hassan Nazia
Published: February 2023

Background: The major portion of the non-communicable diseases is formed by cardiovascular diseases. The two major modifiable risk factors are hypertension and diabetes. The probable CVD risk with pre-hypertension and pre-diabetes, to some extent, is dependent on whether pre-HTN leads to hypertension and pre-DM leads to diabetes. Our aim was to study: the progression of prehypertension and prediabetes to overt hypertension and diabetes or to normal status, and the association of pre-obesity and obesity with prehypertension and prediabetes.
Methods: A total of 1200 patients equally distributed among three groups were studied for progression or regression. Group A included 400 patients of pre-hypertension, and group B included 400 patients of pre-diabetes and group C included 400 patients of pre-diabetes and pre-hypertension.
Results: Among the 400 studied patients with prediabetes 31 (7.8%) progressed to diabetes and only 9 (2.3%) progressed to hypertension over a period of two years. Patients with both prehypertension and prediabetes had a higher risk of progression to hypertension and diabetes (3% to hypertension and 15.5% to diabetes). Males were more prone to develop both pre-hypertension and pre-diabetes mellitus and progression. Obesity increased the risk of progression to hypertension and diabetes significantly.
Conclusions: The screening of people for pre-diabetes mellitus and pre-hypertension should be carried out at mass levels so as to diagnose them at an early stage and hence, their progression can be either halted or modified.
Study of association of dry eye with diabetes mellitus
Authors: Chandra Shekhar Majumder  , M. Golam Mustafa Majumder  , Inamur Rahman Choudhury
Published: February 2023

Background: Aim of the study was to evaluate the tear status in diabetes mellitus (DM) patient.
Methods: This study was a prospective observational case control study. Eighty patients with DM aged from 50 to 80 years were compared with a group of 80 normal healthy age matched control group. A general ophthalmological check-up was performed. The main points of comparison were subjective complaints, objective findings on basic Schirmer test, break-up time, Rose Bengal test.
Results: The results show that 27.5% of all diabetic subjects accompanied of dry eye symptoms, as against 6.25% of the control group. A mean BUT value was 15.5s and Standard Error was 0.20. In the control group mean BUT value was 14s and standard error was 0.23. Basic Schirmer test in DM group mean value was 9.50 mm and SE was 0.268. In the control group mean basic Schirmer test value was 15 mm and SE was 0.405. Rose Bengal test score in DM group, normal score (score <3) was found in 80% case and abnormal score (score >3) was found in 20%. In the control group, normal score was found in 93.75% and abnormal score was found in 6.25% case. Dry eye percentage in DM group 11.25% had definitive dry eye, 16.25% cases had possible dry eye and 72.5% cases had no dry eye. In control group 2.50% cases had definitive dry eye, 3.75% cases had possible dry eye and 93.75% had no dry eye.
Conclusions: The study shows that dry eye is associated with DM.
Effect of asenapine and iloperidone on weight gain in patients of psychosis: a prospective study
Authors: Koduru Neeraja  , C. Keerthi  , S. Sharon Sonia
Published: February 2023

Background: Second generation or atypical antipsychotics are the most commonly used effective drugs for psychotic disorders like schizophrenia. But the drawback with the use of these drugs is that they tend to cause adverse effects; among which weight gain is an important one with risk of diabetes and adverse cardiovascular events. Weight gain is less with newer atypical antipsychotics. This study was conducted to compare weight gain with two newer atypical antipsychotic drugs, Asenapine and Iloperidone
Methods: It is a prospective study conducted on a total of 60 subjects who were diagnosed with schizophrenia or acute psychosis according to ICD 10 guidelines. The subjects were divided into two groups of 30 each. They received Asenapine (5-20 mg) and Iloperidone (8-24 mg) and were followed-up with weight measurements at baseline, week 1, week 3 and week 6.
Results: Out of 60 subjects, 5 patients were lost to follow-up. The mean weight gain in each of the groups was 2.18±1.84 kg with Iloperidone and 1.63±1.28kg with Asenapine, which was statistically not significant. Weight gain was dose-dependent, 3.63kg mean weight gain with 15-20 mg Asenapine and 3.45 kg with 18-24 mg Iloperidone; which was statistically significant.
Conclusions: Weight gain was seen with both the atypical antipsychotic drugs, Asenapine and Iloperidone; which was only of mild to moderate degree. Among the two study drugs, Iloperidone showed more weight gain than Asenapine.
Estimation of triple prognostic factors: serum ferritin, D-dimer and HbA1c levels in post-COVID mucormycosis patients: a cross-sectional observational study
Authors: Nishant Gupta  , Siddharth Nirwan  , Pawan Singhal  , Samta Verma  , Mansi Raj  , Jitendra Kumar Jangir  , Kailash Singh Jat  , Anjani Kumar Sharma
Published: February 2023

Background: India was furiously hit by the second wave of COVID-19 that peaked during the months of April and May 2021. It led to an unprecedented number of rhino-orbital-cerebral mucormycosis cases that came as a bitter surprise. Several parameters were found to be consistently elevated in the patients like serum ferritin, D-dimer, and HbA1C.
Methods: A cross-sectional observational study was conducted at the SMS medical college that included 120 patients presenting with post-COVID mucormycosis from 1st May to 31st May 2021. HbA1c, D-dimer, serum ferritin levels were measured at the time of admission.
Results: Our study showed a mean range of serum ferritin of 539.6±484.9, mean D-dimer range was 636.3±303.5, both of which were higher than normal. In the present study 94.1% of the patients had diabetes mellitus. Among them 60.80% of the patients had newly detected diabetes and 33.30% were known cases of diabetes with mean HbA1c 9.7±2.3. The p value was less than 0.001 which was statistically significant.
Conclusions: Timely detection and categorization of the patients based on severity of the above parameters can not only help in executing the existing institutional resources but can also help in saving valuable lives, and preventing radical surgical procedures like orbital exenteration and maxillectomy.
Influencia de las bacterias en la autocuración del concreto
Authors: Muñoz-Pérez Sócrates , Carlos-Sánchez Jorge , Peralta-Sánchez Miguel
Published: February 2023

El presente documento contempla una reflexión crítica de los avances tecnológicos en ensayos biológicos y químicos que es sometido el concreto mediante la incorporación de bacterias, con el objetivo de conocer los distintos elementos microbianos que poseen propiedades de biomineralización capaces de realizar la autocuración en el concreto, asimismo, se revisaron métodos y aplicaciones de las bacterias en el concreto con el fin de mejorar sus propiedades mecánicas a las diferentes exigencias sometidas las estructuras modernas, y al mismo tiempo contribuir con la reducción de gases dañinos al medio ambiente. En el desarrollo de este manuscrito se revisaron 80 artículos indexados entre los años 2017 al 2021 distribuidos de la siguiente manera, 51 en Scopus, 17 en Ebsco, y 12 en SciencieDirect, señalando y describiendo que el concreto microbiano tiene un enfoque prometedor en un futuro cercano. Los resultados alcanzados con la incorporación de las diferentes bacterias de Bacillus, como son Bacillus subtillis, B, cohnii, B. pasteurii, B. pseudofirmus, B. megaterium entre otros, en diferentes concentraciones de células/ml., mostraron gran efectividad en la cicatrización de grietas, aumentando también la resistencia a la compresión, flexión y tracción en el concreto. Sobre la base de la revisión literaria se concluye que la precipitación microbiana de carbonato de calcio mediante ureólisis en la matriz del concreto, mitiga el agrietamiento, mejora la resistencia, aumenta la durabilidad y, por lo tanto, disminuye los costes en reparación de las estructuras.
On the Role of Criticism in Literary Process of the Beginning of the XX‑th Century from the Point of View of Perception
Authors:   St. Petersburg State University of Industrial Technologies and Design, Boeva Galina N.
Published: February 2023

The subject of this article is the analysis of the complexity of literary texts perception in the beginning of the XX-th century, the epoch of change of a cultural paradigm. The author considers such new lines of literary process as «the fashionable writer», change of a publishing policy and type of reader’s perception.
Communication Matrixes In Dialogue: the Role of Mass Media in Forming the Modern Media Space (on the material of China Radio International)
Authors:   Altai State Pedagogical University, Monastyryova O. V.
Published: February 2023

The modern Media Space is a system that uses integrated new methods of communication. The article is focused on the analysis of «matrix of communication» category by intent-analysis in the programs of China Radio International. The role and the main intentions of forming the China’s image in the media discourse are revealed.
Association of cytotoxic T-lymphocyte-associated protein 4 polymorphisms with recurrent pregnancy loss: A case-control study
Authors: Vaziri Nezamdoust Fereshteh , Hadinedoushan Hossein , Ghasemi Nasrin
Published: February 2023

Background: A large proportion of cases of recurrent pregnancy loss (RPL) are associated with immunological factors.
Objective: This study investigated the association between single nucleotide polymorphisms of cytotoxic T lymphocyte-associated protein (CTLA)-4 gene in women with a history of RPL compared to healthy women. Materials and Methods: A case-control study was performed on 2 groups consisting of 120 healthy women with no history of abortion and at least one delivery (control) and 120 women with a history of 2 or more primary RPLs (case). In addition, 5 mL of peripheral blood sample was taken from all subjects. The frequencies of CTLA-4 rs3087243 and rs231775 polymorphisms were assayed by restriction fragment length polymorphism polymerase chain reaction and rs5742909 using the high-resolution melting real-time polymerase chain reaction method.
Results: The mean age of the women in the control and RPL groups were 30.03 ± 4.23 (range 21-37), and 28.64 ± 3.61 yr (range 20-35), respectively. Pregnancy loss numbers ranged between 2-6 in women with a history of RPL, and between 1 and 4 in the successful pregnancy group. Statistical analysis showed a significant difference between the genotypes of GG and AG in the 2 groups in rs3087243 polymorphism (OR 1.00 for GG genotype and OR 2.87 for AG genotype, p = 0.0043). No significant difference was observed in the genotype frequencies of rs231775 and rs5742909 polymorphisms, of the 2 groups (p = 0.37, and p = 0.095), respectively.
Conclusion: Our findings indicated that CTLA-4 polymorphism, rs3087243, might be associated with a risk of RPL in Iranian women.
Key words: Recurrent pregnancy loss, Single nucleotide polymorphisms, CTLA-4 gene.
The role of the Coronavirus pandemic on childbearing intentions in Iranian women based on path analysis: A cross-sectional study
Authors: Banaei Mojdeh , Kariman Nourossadat , Sharif Nia Hamid , Mokhtarian-Gilani Tahereh
Published: February 2023

Background: The Coronavirus disease (COVID-19) may lead to couples not being physically and mentally ready to assume a parenting role.
Objective: Given the changes in reproductive behaviors and the lack of accurate information about childbearing factors during the Coronavirus pandemic, this study was conducted to investigate the role of the COVID-19 pandemic in Iranian couples’ childbearing intentions based on the theory of planned behavior model.
Materials and Methods: This cross-sectional study was conducted on 400 married Iranian women from July to October 2020 using official online popular social networks. Data were collected using a demographic checklist and the researcher-made questionnaire, which was designed based on the main constructs of the planned behavior model.
Results: Testing the indirect relationships of the mediation model effect showed a positive relationship between knowledge (β = 0.226, p < 0.001) and subjective norms (β = 0.155, p = 0.001) about COVID-19. Anxiety about COVID-19 mediated the relationship of knowledge (β = 0.105, p = 0.009), attitude (β = -0.125, p = 0.002), subjective norms (β = 0.238, p < 0.001), and perceived behavioral control (β = 0.513, p < 0.001) about COVID-19 with childbearing intentions.
Conclusion: The results showed that COVID-19-induced anxiety can affect the relationship between the components of the theory of planned behavior model and childbearing intentions. Therefore, it is suggested that by designing appropriate interventions through anxiety-reducing and relaxation techniques, a fundamental step can be taken in increasing childbearing desires.
Key words: Iran, Delayed childbearing, Reproductive behavior, COVID-19, Attitude.
Ableism and Exclusion
Authors:   University of Kent, UK, Leigh Jennifer , Caplehorne Josie ,   University of Kent, UK, Slowe Sarah ,   University of Kent, UK
Published: February 2023

Academic institutions are abelist. This, however, does not have to be the case. How do individuals involved in research management address this culture? In the context of the drastic changes in Higher Education since the 1990s, and an increasing emphasis on equality and inclusion, initiatives such as Athena Swan and the Race Equality Charter have led to more awareness of exclusionary practices. However, statistics on disability highlight serious issues in relation to disclosure rates for staff and staff report being stigmatised and their career choices undermined or invalidated. This can be particularly true for those who research into or around ableism. In this environment how can research managers raise awareness and empower all academics to ask for and gain adjustments to support their work? How has the Covid-19 pandemic and the impact on higher education institutions and their finances affected this issue? In this paper we consider some of the challenges of conducting research on ableism in academia and what it can tell us. We then discuss the changes that can be made to research management that would help address and challenge the ableist academic culture. This would be achieved through raising expectations, placing inclusivity and accessibility at the heart of research communication and encouraging, equipping and challenging the academic community to embed these practices in the dissemination of their research.
Applications of New Generation Solvents for Extraction of Herbal Products Prior to Atomic and Molecular Analysis
Authors: IŞIK Selin , USMAN Abdullahi
Published: February 2023

In this review, an up to date and current knowledge of some of the green solvents, which includes supercritical fluids extraction (SFE), switchable polarity solvents (SPS), and natural deep eutectic solvents (NADES) are discussed with more emphasis on the extraction of active components of herbal products. Different scientific articles and books have been researched and reviewed to explain the applications of new generation solvents for extraction of herbal products prior to atomic and molecular analysis from the past until now. Currently, the most of techniques used in processing herbal products involve the use of extraction methods. Therefore, trends in extraction methods focuses mainly on finding reasonable solutions that minimizes the use of toxic solvents and allows the usage of renewable and green solvents from natural products, which ensure high quality and safe extracts. In future, SFE is definitely going to be on the industrial scale due to its numerous applications in the large scale especially for herbal, food, cosmetics and pharmaceutical products etc.
Synthesis, Spectral Characterization, Crystal Structure, and Antioxidant Properties of novel Palladium(II) Complex from ONS Donor 1,5-bis(2-hydroxybenzylidene)thiocarbohydrazone
Authors: KAYA Yeliz
Published: February 2023

A new Pd(II) complex, [Pd(PPh3)(L)] (L = 1,5-bis(2-hydroxybenzylidene)thiocarbohydrazone, PPh3 = triphenylphosphine), was synthesized and characterized by FTIR, 1H NMR and UV-Vis spectroscopies and elemental analysis. The molecular structure of [Pd(PPh3)(L)] was confirmed by the single-crystal X-ray diffraction technique. Palladium ion has distorted square planar geometry according to X-ray diffraction studies. The free thiocarbohydrazone (L), potentially a pentadentate ONSNO donor, acted as a tridentate ONS donor. The antioxidant capacity of the free thiocarbohydrazone and Pd(II) complex was determined using the CUPRAC (cupric reducing antioxidant capacity) method. Also, the DPPH method was used to test the free radical scavenging activity of the free thiocarbohydrazone and Pd(II) complex. Antioxidant activity studies showed that free thiocarbohydrazone exhibited better activity than Pd(II) complex.
Relationship of deaths caused by malignant neoplasm of stomach with healthy life expectancy (HALE) : a time-based longitudinal analysis on the ICD-10 mortality list
Authors: ALTUNAL Çetin , ŞAHİNER İbrahim Tayfun
Published: February 2023

Aim: In this research, it was aimed to evaluate relationship of deaths caused by malignant neoplasm of stomach with healthy life expectancy (HALE) : a time-based longitudinal analysis on the ICD-10 mortality list.

Material and Method: World Health Organization (WHO) ICD-10 mortality data and WHO-HALE at birth and HALE at 60 ages for 14 countries between 1996-2017 were used. Spearman’s rho, year controlled partial correlation analysis and Logit model was used for analysis of research parameters.

Results: Minimum total death was 1, and maximum was 25.898 for all years and countries. The mean death was 3.030.50±6.307.23. HALE at birth mean was 62.75±4.52, and HALE at 60 age mean was 13.93±1.90. Both Spearman’s rho correlation analysis and year controlled partial correlation analysis results showed that malignant neoplasm of stomach death is negatively correlated with HALE at birth and HALE at 60 ages (p
Optimal use of supports in interposing a pipeline into the submerged crossing well. Part 2
Authors: Ovchinnikov N.T.
Published: February 2023

The paper considers the problem of supports optimal arrangement in pulling a pipeline through the well during construction of the submerged crossing by the directional drilling method. Part 1 of this work presented results of using the pipeline rod model with positioning the transition section on the fixed supports with the variable lift height. Part 2 simulates the use of a group of the movable supports. Initially, the group working stroke is carried out accompanied by the supports positioning towards the well with a decrease in the pipeline height. After a stop in the final position, the group is being restructured taking the initial position for the next motion cycle. When the supports are moved, optimality conditions are met in the form of the missing contact load behind the well inlet and minimum stresses in the transition section, or the minimum supports reaction. The supports are brought to their initial state by taking the first support behind the last support, or by moving each of the supports in turn to the required position. The presented solution allows pulling through at the technologically determined minimum impact of the mounting loads on the pipeline.
Stability of the spherical motion of a solid body with an inhomogeneous fluid performing a uniform vortex motion
Authors: Win Ko Ko , Temnov A.N. , Yan Naing Oo
Published: February 2023

In this paper, the equations of spherical motion of a solid body with a rotating inhomogeneous incompressible fluid that fills a completely ellipsoidal cavity are obtained and investigated. The stability of rotation of a solid with an inhomogeneous fluid having a linear density distribution is considered. Arbitrary fields of density and velocity of fluid particles are represented as a power series by spatial variables with coefficients that depend only on time. Sufficient conditions for the stability of the rotation of a solid body with a fluid around the vertical axis of dynamic symmetry are presented. The obtained equations of motion make it possible to study the stability of stationary motions of the system under consideration in order to assess the effect of fluid separation on the dynamics of the body. By analogy with the motion of a solid body, it is stated that the obtained conditions are also necessary and sufficient conditions for stationary rotations of an inhomogeneous fluid in an ellipsoidal cavity.
On practical methods to determine porometric characteristics of thin samples made from combined porous mesh material
Authors: Alexandrov L.G. , Konstantinov S.B. , Markov A.V. , Novikov Y.M. , Platov I.V.
Published: February 2023

On the example of a porous structure operation in the gas-liquid flow as the phase separator, the paper demonstrates the porometric characteristics effect to assess its performance in the capillary-type intra-tank devices of the space propulsion system fuel tanks. It is shown that for manufacture of a permeable phase separator taking into account the stable capillary structure and the possibility to obtain the hydraulic resistance given value, it is advisable to introduce a combined porous mesh material. For practical determination of one of the porous structure characteristics, i.e. the capillary holding capacity, a method is presented for preparing the permeable structure surface of the phase separator material for testing based on the “bubble” technique, and principles of using such wetting liquids as water, glycerin or ethyl alcohol are discussed. Taking into account small thicknesses of the phase separators made of combined porous materials, types of the circuit solutions of the test installations are provided for determining the capillary holding capacity of porous mesh materials differing from the traditional ones used in orosimetry of soils, rocks and filter materials obtained on the basis of powder metallurgy.
School Refusal and Cognitive Behavioral Therapy: A Review
Authors: ŞANAL GÜNGÖR Beyza , KOÇTÜRK Nilüfer
Published: February 2023

School refusal is a problem area that can turn into difficult trouble for the family, school, and students by affecting children and adolescents' academic and psychosocial development. This scoping review aims to examine the effectiveness of interventions based on the cognitive behavioral therapy approach on children and adolescents experiencing school refusal. The study was carried out following the "Standards Used in Reporting of Systematic Compilation and Meta-Analysis Results." For this purpose, the databases of DergiPark, Google Scholar, PsycARTICLES, PubMed, TR Index, and Web of Science were searched without any year restriction. As a result of the search, 233 studies were reached, and according to the inclusion criteria, ten research articles were evaluated. According to the findings, cognitive-behavioral interventions applied to children with school refusal: cognitive restructuring (n = 10, 100%), exposure (n = 10, 100%), psychoeducation (n = 6, 60%), social skills training (n = 6, 60%), problem solving training (n = 4, 40%), relaxation training (n = 4, 40%) and homework (n = 4, 40%) are predominantly used techniques. In 80% of the studies, it was determined that interventions based on the cognitive behavioral therapy approach to school refusal were effective. Parental involvement was also included in 80% (n = 8) of the studies, and 100% had effective results. Cognitive behavioral interventions are effective on school refusal as a result of the studies reviewed.
Properties of Winemaking By-products of Feteasca Neagra Grape Seeds
Authors: Gurev Angela , Dragancea Veronica , Baerle Alexei , Netreba Natalia , Boestean Olga , Haritonov Svetlana , Gaina Boris
Published: February 2023

The composition of the lipophilic and hydrophilic extracts from the Feteasca Neagra ground seeds, grown in three different vineyards, was studied. The physicochemical indicators of the seeds, the oil quality indicators and the total content of polyphenols and flavonoids in the extracts were determined. Some phenolic and flavanol constituents were identified and quantified using reversed-phase HPLC by gradient-elution. The Trolox equivalent antioxidant capacity assay proved the increased antioxidant activity of the hydrophilic extracts, with the highest DPPH• scavenging effect of almost 91.70 and 93.81%, an equivalent of 281.66 and 288.27 µM/L Trolox. It was concluded that the seeds recovered from Feteasca Neagra by-products are a rich source of functional compounds, with significant antioxidant properties.
From (-)-sclareol to Norlabdane Heterocyclic Hybrid Compounds
Authors: Ciocarlan Alexandru
Published: February 2023

This review relates to chemistry of the well-known biologically active natural labdane diterpenoid (-)-sclareol easily available from Clary sage (Salvia sclarea L.). It is mainly used in industry, especially for synthesis of fragrance compounds and natural analogs. The paper covers achievements on the synthesis, structure determination and biological activity of molecular hybrid compounds bearing hydrazide and thiosemicarbazone fragments or diazine, 1,2,4-triazole, carbazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole units prepared based on it.
Application of 3D modeling in a personalized approach to bone osteosynthesis (A literature review)
Authors: Pankratov A. S. , Lartsev Yu. V. , Rubtsov A. A. , Ogurtsov D. A. , Kim Yu. D. , Shmel'kov A. V. , Knyazev N. A.
Published: February 2023

Three-dimensional printing opens up many opportunities for use in traumatology and orthopedics, because it takes into account personal characteristics of the patients. Modern methods of high-resolution medical imaging can process data to create threedimensional images for printing physical objects. Today, three-dimensional printers are able to create a model of any complexity of shape and geometry. The article provides a review of the literature about three-dimensional digital modeling in shaping implants for osteosynthesis. Data search was carried out on the Scopus, Web of Scince, Pubmed, RSCI databases for the period 2012–2022. The effectiveness of three-dimensional printing for preoperative modeling of bone plates has been confirmed: implants perfectly corresponds with the unique anatomy of the patient, since the template for it is based on the materials of computed tomography. Individual templates can be useful when the geometry of patients' bones goes beyond the standard, and when improved results of surgery are expected due to better matching of implants to the anatomical needs of patients.
Study of the dynamics of catalase activity in blood and liver tissue of old rats at experimentally induced dyslipoproteinemia against the background of mechanical damage to the skeletal muscle
Authors: Pavlova O. N. , Tulaeva O. N.
Published: February 2023

The population of Russia, as well as the population of the developed countries, is steadily aging. Atherosclerosis in elderly patients is most often manifested by acute and severe forms, such as heart attack and stroke. With age, there is an intensification of oxidative processes and a decrease in the activity of antioxidant enzymes. Creation of experimental model of dislipoproteinemia followed by skeletal muscle mechanical trauma in rats will allow to reveal the regularities of oxidative homeostasis changes and use the data obtained in therapy of elderly patients with atherosclerosis.

Aim of the investigation: to study the dynamics of catalase activity in blood and tissues of aged rats under oxidative stress caused by modeling of dyslipoproteinemia followed by mechanical injury of skeletal muscle.

Materials and methods. The investigation was performed on 120 white non-pedigreed healthy male rats aged 24 months (old rats) weighing 230–250 grams. All animals were divided into four groups, 30 rats in each. The animals in the first group were intact rats, to which no treatment was applied. The animals in the second group had a mechanical dissection in the middle third of the hind limb calf muscle. Animals in groups one and two were on a standard vivarium diet and had free access to water and food. The animals of the third and fourth groups were subjected to simulated dyslipoproteinemia for 63 days and received a high-carbohydrate and high-fat diet with an increased fat content up to 30% by weight of dry matter and replacement of drinking water by a 20% fructose solution. After a certain period of time, the animals in the fourth group underwent injuries of the middle third of the hind limb calf muscle.

Conclusions. Mechanical trauma combined with dyslipoproteemia in aged rats is characterized by intense oxidative stress and leads to the decrease of activity of the antioxidant enzyme catalase in blood and liver tissues.
Esferocitose Hereditária e Gravidez: A Propósito de um Caso Clínico
Authors: Miguel Andreia , Alves Maria José , Massa Ana Catarina
Published: February 2023

A esferocitose hereditária (EH), embora rara, constitui a principal causa de anemia hemolítica hereditária, tendo uma apresentação clínica muito diversa. Raros casos de grávidas com EH estão publicados, tendo um impacto incerto nos desfechos maternos e fetais. Os relatos de gestações complicadas por EH e de complicações trombóticas ou hipertensão portal são particularmente escassos. Apresentamos o caso de uma grávida esplenectomizada, com EH e hipertensão portal não cirrótica. A utente apresentava polimorfismos da metiltetrahidrofolato redutase e fator inibidor do ativador do plasminogénio, mutações com impacto controverso no risco trombótico. Durante a gestação não ocorreu deterioração hemodinâmica ou hepática, diagnosticando-se restrição de crescimento fetal tardia que não condicionou término precoce da gravidez. Cinco semanas após o parto, surgiu um quadro de dor abdominal, tendo-se diagnosticado trombose de veia mesentérica. Descrevemos a nossa experiência de vigilância da gravidez, parto e puerpério de uma mulher com EH grave, com destaque para potenciais complicações associadas à EH.