bluuebunny/crossref_metadata_2025 huggingface dataset:
Substrate Temperature Dependent Properties of Sputtered AlN:Er Thin Film for In-Situ Luminescence Sensing of Al/AlN Multilayer Coating Health
Authors: Fang Liping , Jiang Yidong , Zhu Shengfa , Ding Jingjing , Zhang Dongxu , Yin Anyi , Chen Piheng
Published: November 2018

The integrity and reliability of surface protective coatings deposited on metal surface could be in-situ monitored via the attractive luminescence sensing technique. In this paper, we report the influence of substrate temperature on the properties of erbium (Er) doped aluminum nitride (AlN) film, which could be applied as a luminescent layer for monitoring the health of multilayered Al/AlN coating. The AlN:Er films were deposited via reactive radio-frequency magnetron sputtering, and the silicon substrate temperature was varied from non-intentional heating up to 400 °C. The composition, morphology, crystalline structure, and dielectric function of the AlN:Er films deposited under these different substrate temperature conditions were studied. These properties of the AlN:Er films show strong correlation with the substrate temperature maintained during film fabrication. The obtained AlN:Er films, without further annealing, exhibited photoluminescence peaks of the Er3+ ions in the visible wavelength range and the strongest photoluminescence intensity was observed for the AlN:Er film deposited with the temperature of substrate kept at 300 °C. The results demonstrated in this work offer guidance to optimize the substrate temperature for the deposition of AlN:Er film for future application of this sensing technique to thin metal components.
An Introduction to 3D Bioprinting: Possibilities, Challenges and Future Aspects
Authors: Kačarević Željka P. , Rider Patrick M. , Alkildani Said , Retnasingh Sujith , Smeets Ralf , Jung Ole , Ivanišević Zrinka , Barbeck Mike
Published: November 2018

Bioprinting is an emerging field in regenerative medicine. Producing cell-laden, three-dimensional structures to mimic bodily tissues has an important role not only in tissue engineering, but also in drug delivery and cancer studies. Bioprinting can provide patient-specific spatial geometry, controlled microstructures and the positioning of different cell types for the fabrication of tissue engineering scaffolds. In this brief review, the different fabrication techniques: laser-based, extrusion-based and inkjet-based bioprinting, are defined, elaborated and compared. Advantages and challenges of each technique are addressed as well as the current research status of each technique towards various tissue types. Nozzle-based techniques, like inkjet and extrusion printing, and laser-based techniques, like stereolithography and laser-assisted bioprinting, are all capable of producing successful bioprinted scaffolds. These four techniques were found to have diverse effects on cell viability, resolution and print fidelity. Additionally, the choice of materials and their concentrations were also found to impact the printing characteristics. Each technique has demonstrated individual advantages and disadvantages with more recent research conduct involving multiple techniques to combine the advantages of each technique.
Effects of CTCP Modification on Microstructure and Wear Behavior of CTCP-NiCrBSi/Heat Resistant Steel Composite Layer
Authors: Zhang Jianjun , Hou Shuzeng
Published: November 2018

A CTCP-NiCrBSi/heat resistant steel composite layer was designed and fabricated by vacuum fusion sintering. The structure of the composite layer was similar to reinforced concrete. Numerous reinforced regions with a cylindrical shape were evenly distributed in the heat resistant steel. Modified cast tungsten carbide particles (CTCP) reinforced NiCrBSi matrix composite constituted the reinforced region (CTCP-NiCrBSi). The microstructure of the composite layers was investigated by scanning electron microscope (SEM), energy dispersive x-ray spectrometer (EDS), and image analysis. The wear behavior of the composite layer was estimated on the ring-on-disc rig at a temperature range of room temperature (RT) to 800 °C in air. The microstructure and wear behavior of the composite layer with modified CTCP were compared with those with primary CTCP. The results showed that the poor chemical resistance of W2C and the interdiffusion of elements were responsible for the dissolution of unmodified CTCP in the molten NiCrBSi alloy. A WC outer shell formed on the surface of the CTCP after surface carburizing modification. The WC outer shell could effectively resist the dissolution of CTCP in NiCrBSi during the sintering process. The content of WC/W2C in modified CTCP-NiCrBSi increased by about 12.0 vol. % when compared with that in the primary CTCP-NiCrBSi. The wear rate of the composite layer with modified CTCP was lower than that with primary CTCP between RT and 700 °C. The wear rates of the composite layer decreased with increasing temperature from RT to 700 °C and increased above 700 °C.
Adsorption of Pb (II) Ions onto Hydroxyapatite Nanopowders in Aqueous Solutions
Authors: Iconaru Simona Liliana , Motelica-Heino Mikael , Guegan Regis , Beuran Mircea , Costescu Adrian , Predoi Daniela
Published: November 2018

Contamination of water with heavy metals such as lead is a major worldwide problem because they affect the physiological functions of living organisms, cause cancer, and damage the immune system. Hydroxyapatite, (Ca5(PO4)3OH) is considered one of the most effective materials for removing heavy metals from contaminated water. The hydroxyapatite nanopowders (N-HAp) obtained by a co-precipitation method were used in this research to determine the effectiveness in removing lead ions from contaminated solutions. In this study, we have investigated the structure and morphology of N-HAp nanopowders using X-ray diffraction (XRD), electronic transmission microscopy (TEM), and scanning electron microscopy (SEM). The structure information was also obtained by spectroscopy measurements. The Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy measurements revealed the presence of peaks corresponding to the phosphate and hydroxyl groups. The ability of N-HAp nanopowders to adsorb lead ions from aqueous solutions were established. The results of the kinetic and equilibrium studies on the removal of Pb (II) from aqueous solution revealed that the adsorption of lead (II) cations is due to the surface reaction with the hydroxyl terminal groups on the adsorbent and the combination of the positive charges of the metal cations with the negative charges on the adsorbent surfaces. These observations could validate the use of these ceramic nanopowders in ecological remediation strategies.
Complex Effect of Concrete Composition on the Thermo-Mechanical Behaviour of Mass Concrete
Authors: Klemczak Barbara , Batog Maciej , Giergiczny Zbigniew , Żmij Aneta
Published: November 2018

The current work presents the complex investigation of the influence of cement and aggregate type on the thermo-mechanical behavior of mass concrete. Six types of cement with different amounts of non-clinker constituents and four types of aggregates are used in experimental tests. Particular attention was given to the low clinker cements with high amounts of siliceous fly ash and ground blast furnace slag. The experimental research covered the determination of thermal, mechanical, and rheological properties of early age concrete with different constituents. Experimental results have been used both to validate the numerical model and analysis of exemplary foundation slab. The results confirm the importance of the concrete mix composition and it has been shown that the early-age volume deformation and possible cracking is the result of the concerted action of thermal and mechanical properties of concrete. The obtained results indicate granite as the best aggregate for mass concrete. Considering the type of cement, much better behaviour of mass concrete has been noted for cements with fly ash and composite cements containing both fly ash and slags than cements only with slag.
Superhydrophobic Surface Preparation and Wettability Transition of Titanium Alloy with Micro/Nano Hierarchical Texture
Authors: Yang Zhiru , Zhu Chongchong , Zheng Nan , Le Dezheng , Zhou Jianzhong
Published: November 2018

Microstructures are applied to various hydrophobic/hydrophilic surfaces due to the role of adjusting the surface wettability. In this paper, a 1064 nm pulsed picosecond laser was applied to prepare a micro/nano hierarchical structure on the surface of the titanium alloy (Ti-6Al-4V). The microstructures consist of dimple arrays with various diameters, depths, and areal densities. They are obtained by controlling the pulse energy and the number of pulses. The nanostructures are periodic ripples, which are defined as laser-induced periodic surface structure (LIPSS), and the dimensional parameter of LIPSS can be adjusted by changing the laser energy density and scanning speed. The contact angles of various laser textured surfaces were measured. It is found that the contact angle increases with the density of micro-textured surface increases, and the wetting state of textured surfaces conforms to the Cassie model. Some laser processed samples were subjected to low-temperature annealing treatment. It is observed that the low-temperature annealing process can accelerate the surface wettability transition significantly, which is attributed to the change of the hydroxyl groups on the surface. Finally, a superhydrophobic surface with the maximum contact angle of 144.58° is obtained.
Topology Choice and Optimization of a Bearingless Flux-Switching Motor with a Combined Winding Set
Authors: Jurdana Vedran , Bulic Neven , Gruber Wolfgang
Published: November 2018

The purpose of this paper is to choose a new topology for bearingless flux-switching slice motors, regarding the number of stator and rotor poles, with a combined winding set. Additionally, the selected motor topology is optimized with finite element method (FEM) simulations to improve the performance. Bearingless slice drives feature a magnetically-suspended rotor disk passively stabilized by reluctance forces due to a permanent magnet (PM) bias flux in the air gap and actively controlled by the generation of radial bearing forces and motor torque. Usage of the combined winding set, where each phase generates both motor torque and suspension forces, opens the opportunity for a new topology. The topology choice and optimization are based on FEM simulations of several motor optimization criteria, as the passive axial, tilting and radial stiffness values and the active torque and bearing forces, which are simulated regarding the motor height and specific stator and rotor parameters. Saturation, cogging torque and cogging forces are also analyzed. The 3D FEM program ANSYS Maxwell 2015 was used. The results led to an optimized bearingless flux-switching motor topology with six new stator segments and seven rotor poles. By optimizing the geometry, a considerable improvement of performance was reached. This geometry optimization is a base for a future prototype model.
On p-Common Best Proximity Point Results for S-Weakly Contraction in Complete Metric Spaces
Authors: Kongban Chayut , Kumam Poom , Komal Somayya , Sitthithakerngkiet Kanokwan
Published: November 2018

In this work, we introduced new notions of a new contraction named S -weakly contraction; after that, we obtained the p-common best proximity point results for different types of contractions in the setting of complete metric spaces by using weak P p -property and proved the uniqueness of these points. Also, we presented some examples to prove the validity of our results.
Edge Version of Metric Dimension and Doubly Resolving Sets of the Necklace Graph
Authors: Liu Jia-Bao , Zahid Zohaib , Nasir Ruby , Nazeer Waqas
Published: November 2018

Consider an undirected and connected graph G = ( V G , E G ) , where V G and E G represent the set of vertices and the set of edges respectively. The concept of edge version of metric dimension and doubly resolving sets is based on the distances of edges in a graph. In this paper, we find the edge version of metric dimension and doubly resolving sets for the necklace graph.
A New Identity Involving the Chebyshev Polynomials
Authors: Zhang Yixue , Chen Zhuoyu
Published: November 2018

In this paper, firstly, we introduced a second order non-linear recursive sequence, then we use this sequence and the combinatorial methods to perform a deep study on the computational problem concerning one kind sums, which includes the Chebyshev polynomials. This makes it possible to simplify a class of complex computations involving the second type Chebyshev polynomials into a very simple problem. Finally, we give a new and interesting identity for it.
Modeling and Simulation of a Hydraulic Network for Leak Diagnosis
Authors: Bermúdez José-Roberto , López-Estrada Francisco-Ronay , Besançon Gildas , Valencia-Palomo Guillermo , Torres Lizeth , Hernández Héctor-Ricardo
Published: November 2018

This work presents the modeling and simulation of a hydraulic network with four nodes and two branches that form a two-level water distribution system. It also proposes a distribution of hydraulic valves that allows emulating a leak using a valve and different network configurations, e.g., simple ducts, closed networks and branched networks. The network is modeled in the steady state considering turbulent flow. Numerical experiments are performed, and the results show that the proposed network is useful for the design of leakage diagnosis and control algorithms in different configurations and leakage scenarios.
Insights on Allergic Rhinitis Management from a Northern Cyprus Perspective and Evaluation of the Impact of Pharmacist-Led Educational Intervention on Patients’ Outcomes
Authors: Arsoy Günay , Varış Ahmet , Saloumi Louai M. , Abdi Abdikarim , Başgut Bilgen
Published: November 2018

Background and objective: the global prevalence of allergic rhinitis (AR) is rising and yet there is scarce information concerning the diagnosis, management and treatment patterns of AR in Northern Cyprus (NC). This study aims to provide a unique perspective on AR management as well as assessing the effectiveness of the pharmacist-led educational intervention for improving care of AR patients. Methods: across-sectional survey was carried out with community pharmacists (n = 70), patients (n = 138) and ear, nose and throat (ENT) specialists (n = 12) in NC. For a controlled interventional trial, trained pharmacists provided a brief education on management of AR and nasal spray technique for patients while other pharmacists provided the usual care. Quality of life (QoL) and other outcome measures on the perceived symptom severity of the two groups were compared after a 6-week period. Results: only 33.3% of the ear, nose and throat (ENT) specialists and 15.7% of the community pharmacists are aware of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The majority of patients (63%) self-managed with over-the-counter medications. Nasal congestion (96.4%) is the most bothersome symptom and oral antihistamines are the most commonly purchased medications (51.4%), indicating a pattern of suboptimal management. The pharmacists-led educational intervention has resulted in statistically more significant improvement in regards to nasal congestion and QoL for the intervention group patients (p < 0.05). Conclusion: the current management of AR has not been in accordance with the ARIA guidelines in NC. An educational intervention of the pharmacists can enhance the symptom management and improve the QoL in patients with AR.
Weld Formation in Laser Hot-Wire Welding of 7075 Aluminum Alloy
Authors: Li Shichun , Xu Wei , Xiao Gang , Chen Bing
Published: November 2018

The laser hot-wire welding process was adopted to weld 7075 high-strength aluminum alloy. The influence laws of parameters on the weld formation were analyzed during laser hot-wire welding, and the microstructure characteristics and mechanical properties of welds were analyzed. The results showed that the parameters whose significance of influence on weld formation as ranked from high to low were laser power, current, gap width, welding speed and wire feeding rate. With the increase of wire temperature, the weld formation quality became better initially and then worse. Under the condition of optimized parameters, good weld formation could be obtained. The weld zone had a fine grain microstructure, and was in casting state consisted of dendritic crystal and equiaxed crystal. The heat affected zone mainly consisted of columnar crystal. The microhardness decreased gradually from base metal to heat affected zone then to weld zone. The tensile fracture of weld specimen occurred at the weld zone, and was in the ductile fracture state. The tensile strength of weld joint was 206 MPa and was 64.2% of base metal strength.
Analysis of the Effect of Tungsten Inert Gas Welding Sequences on Residual Stress and Distortion of CFETR Vacuum Vessel Using Finite Element Simulations
Authors: Zhang Jingwen , Yu Liming , Liu Yongchang , Ma Zongqing , Li Huijun , Liu Chenxi , Wu Jiefeng , Ma Jianguo , Li Zhanlun
Published: November 2018

The as-welded sectors of China Fusion Engineering Testing Reactor (CFETR) vacuum vessel (VV) have very tight tolerances. However, it is difficult to investigate the welding stress and distortion without the production of a full-scale prototype. Therefore, it is important to predict and reduce the welding stress and distortion to guarantee the final assembly by using an accurately adjusted finite element model. In this paper, a full-scale finite element model of the 1/32 VV mock-up was built by ABAQUS which is a powerful finite element software for engineering simulation, and three different tungsten inert gas (TIG) welding sequences were simulated to study the effect of welding sequences on the welding stress and distortion. The results showed that the main welding stress happened on the weld zone, and the maximum distortion occurred on the shell near the welding joints between the inboard segment (PS1) and the lower segment (PS4). The inboard segment (PS1), upper segment (PS2), and lower segment (PS4) distorted to inside of the shell perpendicularly, while the equatorial segment (PS3) distorted to outside of the shell perpendicularly. According to the further analysis, the maximum welding stresses in sequence 1, sequence 2, and sequence 3 were 234.509 MPa, 234.731 MPa, and 234.508 MPa, respectively, and the average welding stresses were 117.268 MPa, 117.367 MPa, and 117.241 MPa, respectively, meanwhile, the maximum welding displacements in sequence 1, sequence 2, and sequence 3 were 1.158 mm, 1.157 mm, and 1.149 mm, respectively, and the average welding displacements were 1.048 mm, 1.053 mm, and 1.042 mm, respectively. Thus, an optimized welding sequence 3 was obtained and could be applied to the practical assembly process of the 1/32 VV mock-up.
Carbon Nanofibers: A New Adsorbent for Copper Removal from Wastewater
Authors: García-Díaz Irene , López Felix Antonio , Alguacil Francisco José
Published: November 2018

This research describes the adsorption of Cu2+ onto a helical ribbon carbon nanofiber. The characterization of carbon nanofiber by zeta potential showed an isoelectronic pH of 1.9. The influence of different adsorption factors, such as stirring speed, temperature, pH, adsorbent concentration, etc., on the Cu2+ adsorption capacity have been evaluated. The pH has a great influence on Cu2+ adsorption, with the maximum adsorption capacity reached at a pH of 10. The experimental data fit well to pseudo-second order kinetic and Langmuir isotherm models (qm = 8.80 mg·g−1) at T = 298 K and pH = 4. The Cu2+ adsorption could be explained by the particle diffusion model. Results showed that carbon nanofiber could be successfully used for the elimination of Cu2+ from wastewater.
Microstructure Evolution of a High Nb Containing TiAl Alloy with (α2 + γ) Microstructure during Elevated Temperature Deformation
Authors: Chu Yudong , Li Jinshan , Zhu Lei , Liu Yan , Tang Bin , Kou Hongchao
Published: November 2018

In order to verify the correctness of the transition of deformation mechanism with the change in deformation parameters and to reveal the types and mechanism of dynamic recrystallization of γ grains during compression deformation, microstructure characterization of Ti-43.5Al-8Nb-0.2W-0.2B (at. %) alloy after isothermal compression deformation were performed. When the alloy was deformed at 1000 °C/10−2 s−1, the initial γ grains are elongated and significantly refined and the fraction of low angle grain boundaries (LAGB) of γ grains is obviously increased and the texture intensity remains unchanged, which indicates that the compression deformation in dislocation creep region is dominated by intragranular deformation and dynamic recrystallization (DRX) of γ grains. Besides, the lattice rotation at grain boundary serrations may be responsible for the nucleation of new recrystallized γ grains, and the following growth process may be achieved by the migration of γ grain boundaries. However, when the alloy deformed at 1050 °C/10−4 s−1 and 1000 °C/10−4 s−1, the γ grains maintain equiaxed shapes and distribute more uniformly and the fraction of LAGB of γ grains is slightly raised and the texture sharpness decreases, which indicates that the compression deformation in grain boundary sliding (GBS) region is mainly controlled by GBS of γ grains and DRX occurs simultaneously within some coarse γ grains.
Design and Analysis of a High-Gain and Robust Multi-DOF Electro-thermally Actuated MEMS Gyroscope
Authors: Saqib Muhammad , Mubasher Saleem Muhammad , Mazhar Naveed , Awan Saif Ullah , Shahbaz Khan Umar
Published: November 2018

This paper presents the design and analysis of a multi degree of freedom (DOF) electro-thermally actuated non-resonant MEMS gyroscope with a 3-DOF drive mode and 1-DOF sense mode system. The 3-DOF drive mode system consists of three masses coupled together using suspension beams. The 1-DOF system consists of a single mass whose motion is decoupled from the drive mode using a decoupling frame. The gyroscope is designed to be operated in the flat region between the first two resonant peaks in drive mode, thus minimizing the effect of environmental and fabrication process variations on device performance. The high gain in the flat operational region is achieved by tuning the suspension beams stiffness. A detailed analytical model, considering the dynamics of both the electro-thermal actuator and multi-mass system, is developed. A parametric optimization is carried out, considering the microfabrication process constraints of the Metal Multi-User MEMS Processes (MetalMUMPs), to achieve high gain. The stiffness of suspension beams is optimized such that the sense mode resonant frequency lies in the flat region between the first two resonant peaks in the drive mode. The results acquired through the developed analytical model are verified with the help of 3D finite element method (FEM)-based simulations. The first three resonant frequencies in the drive mode are designed to be 2.51 kHz, 3.68 kHz, and 5.77 kHz, respectively. The sense mode resonant frequency is designed to be 3.13 kHz. At an actuation voltage of 0.2 V, the dynamically amplified drive mode gain in the sense mass is obtained to be 18.6 µm. With this gain, a capacitive change of 28.11   f F and 862.13   f F is achieved corresponding to the sense mode amplitude of 0.15   μ m and 4.5   μ m at atmospheric air pressure and in a vacuum, respectively.
Research on a 3-DOF Motion Device Based on the Flexible Mechanism Driven by the Piezoelectric Actuators
Authors: Lv Bingrui , Wang Guilian , Li Bin , Zhou Haibo , Hu Yahui
Published: November 2018

This paper describes the innovative design of a three-dimensional (3D) motion device based on a flexible mechanism, which is used primarily to produce accurate and fast micro-displacement. For example, the rapid contact and separation of the tool and the workpiece are realized by the operation of the 3D motion device in the machining process. This paper mainly concerns the device performance. A theoretical model for the static performance of the device was established using the matrix-based compliance modeling (MCM) method, and the static characteristics of the device were numerically simulated by finite element analysis (FEA). The Lagrangian principle and the finite element analysis method for device dynamics are used for prediction to obtain the natural frequency of the device. Under no-load conditions, the dynamic response performance and linear motion performance of the three directions were tested and analyzed with different input signals, and three sets of vibration trajectories were obtained. Finally, the scratching experiment was carried out. The detection of the workpiece reveals a pronounced periodic texture on the surface, which verifies that the vibration device can generate an ideal 3D vibration trajectory.
High Performance Seesaw Torsional CMOS-MEMS Relay Using Tungsten VIA Layer
Authors: Riverola Martín , Torres Francesc , Uranga Arantxa , Barniol Núria
Published: November 2018

In this paper, a seesaw torsional relay monolithically integrated in a standard 0.35 μm complementary metal oxide semiconductor (CMOS) technology is presented. The seesaw relay is fabricated using the Back-End-Of-Line (BEOL) layers available, specifically using the tungsten VIA3 layer of a 0.35 μm CMOS technology. Three different contact materials are studied to discriminate which is the most adequate as a mechanical relay. The robustness of the relay is proved, and its main characteristics as a relay for the three different contact interfaces are provided. The seesaw relay is capable of a double hysteretic switching cycle, providing compactness for mechanical logic processing. The low contact resistance achieved with the TiN/W mechanical contact with high cycling life time is competitive in comparison with the state-of-the art.
Recent Developments for Flexible Pressure Sensors: A Review
Authors: Xu Fenlan , Li Xiuyan , Shi Yue , Li Luhai , Wang Wei , He Liang , Liu Ruping
Published: November 2018

Flexible pressure sensors are attracting great interest from researchers and are widely applied in various new electronic equipment because of their distinct characteristics with high flexibility, high sensitivity, and light weight; examples include electronic skin (E-skin) and wearable flexible sensing devices. This review summarizes the research progress of flexible pressure sensors, including three kinds of transduction mechanisms and their respective research developments, and applications in the fields of E-skin and wearable devices. Furthermore, the challenges and development trends of E-skin and wearable flexible sensors are also briefly discussed. Challenges of developing high extensibility, high sensitivity, and flexible multi-function equipment still exist at present. Exploring new sensing mechanisms, seeking new functional materials, and developing novel integration technology of flexible devices will be the key directions in the sensors field in future.
A Novel One-Transistor Dynamic Random-Access Memory (1T DRAM) Featuring Partially Inserted Wide-Bandgap Double Barriers for High-Temperature Applications
Authors: Kim Myeongsun , Ha Jongmin , Kwon Ikhyeon , Han Jae-Hee , Cho Seongjae , Cho Il Hwan
Published: November 2018

These days, the demand on electronic systems operating at high temperature is increasing owing to bursting interest in applications adaptable to harsh environments on earth, as well as in the unpaved spaces in the universe. However, research on memory technologies suitable to high-temperature conditions have been seldom reported yet. In this work, a novel one-transistor dynamic random-access memory (1T DRAM) featuring the device channel with partially inserted wide-bandgap semiconductor material toward the high-temperature application is proposed and designed, and its device performances are investigated with an emphasis at 500 K. The possibilities of the program operation by impact ionization and the erase operation via drift conduction by a properly high drain voltage have been verified through a series of technology computer-aided design (TCAD) device simulations at 500 K. Analyses of the energy-band structures in the hold state reveals that the electrons stored in the channel can be effectively confined and retained by the surrounding thin wide-bandgap semiconductor barriers. Additionally, for more realistic and practical claims, transient characteristics of the proposed volatile memory device have been closely investigated quantifying the programming window and retention time. Although there is an inevitable degradation in state-1/state-0 current ratio compared with the case of room-temperature operation, the high-temperature operation capabilities of the proposed memory device at 500 K have been confirmed to fall into the regime permissible for practical use.
The Balancing Act in Ferroelectric Transistors: How Hard Can It Be?
Authors: Hueting Raymond J. E.
Published: November 2018

For some years now, the ever continuing dimensional scaling has no longer been considered to be sufficient for the realization of advanced CMOS devices. Alternative approaches, such as employing new materials and introducing new device architectures, appear to be the way to go forward. A currently hot approach is to employ ferroelectric materials for obtaining a positive feedback in the gate control of a switch. This work elaborates on two device architectures based on this approach: the negative-capacitance and the piezoelectric field-effect transistor, i.e., the NC-FET (negative-capacitance field-effect transistor), respectively π -FET. It briefly describes their operation principle and compares those based on earlier reports. For optimal performance, the adopted ferroelectric material in the NC-FET should have a relatively wide polarization-field loop (i.e., “hard” ferroelectric material). Its optimal remnant polarization depends on the NC-FET architecture, although there is some consensus in having a low value for that (e.g., HZO (Hafnium-Zirconate)). π -FET is the piezoelectric coefficient, hence its polarization-field loop should be as high as possible (e.g., PZT (lead-zirconate-titanate)). In summary, literature reports indicate that the NC-FET shows better performance in terms of subthreshold swing and on-current. However, since its operation principle is based on a relatively large change in polarization the maximum speed, unlike in a π -FET, forms a big issue. Therefore, for future low-power CMOS, a hybrid solution is proposed comprising both device architectures on a chip where hard ferroelectric materials with a high piezocoefficient are used.
The Discovery of the Romero VMS Deposit and Its Bearing on the Metallogenic Evolution of Hispaniola during the Cretaceous
Authors: Torró Lisard , Proenza Joaquín , Espaillat Julio , Belén-Manzeta Albert , Román-Alday María , Amarante Alberto , González Norverto , Espinoza Jorge , Román-Alpiste Manuel , Nelson Carl
Published: November 2018

The recently discovered Romero deposit, located in the Tres Palmas district, Cordillera Central of the Dominican Republic, has probable reserves of 840,000 oz gold, 980,000 oz silver and 136 Mlb copper. Mineralization is hosted by intermediate volcanic and volcaniclastic rocks of the lower stratigraphic sequence of the Cretaceous Tireo formation. The andesitic host rocks yield a U-Pb zircon concordia age of 116 ± 10 Ma. Au–Ag–Cu(–Zn) mineralization is divided into: (1) an upper domain with stacked massive sulfide lenses and sulfide dissemination within a 20-m-thick level of massive anhydrite-gypsum nodules, and (2) a lower domain with a high-grade stockwork mineralization in the form of cm-scale veins with open space fillings of fibrous silica and chalcopyrite, sphalerite, pyrite (+electrum ± Au–Ag tellurides). The δ34S values of sulfides from the upper (−7.6 and +0.9‰) and lower (−2.4 and +5.6‰) domains are consistent with a heterogeneous sourcing of S, probably combining inorganically and organically induced reduction of Albian-Aptian seawater sulfate. Despite this, a magmatic source for sulfur cannot be discarded. The δ34S (+19.2 and +20.0‰) and δ18O (+12.5 and +14.2‰) values of anhydrite-gypsum nodules are also consistent with a seawater sulfate source and suggest crystallization in equilibrium with aqueous sulfides at temperatures higher than 250 °C. These data point to a classification of Romero as a volcanogenic massive sulfide (VMS) deposit formed in an axial position of the Greater Antilles paleo-arc in connection with island arc tholeiitic magmatism during a steady-state subduction regime. Circulation of hydrothermal fluids could have been promoted by a local extensional tectonic regime expressed in the Tres Palmas district as a graben structure.
Elemental Geochemical Evidence for Depositional Conditions and Organic Matter Enrichment of Black Rock Series Strata in an Inter-Platform Basin: The Lower Carboniferous Datang Formation, Southern Guizhou, Southwest China
Authors: Ding Jianghui , Zhang Jinchuan , Tang Xuan , Huo Zhipeng , Han Shuangbiao , Lang Yue , Zheng Yuyan , Li Xingqi , Liu Tong
Published: November 2018

The Datang Formation black rock series deposited in an inter-platform basin are considered to be one of the main source rocks in Southwest China. However, their depositional conditions and organic matter enrichment in such a setting are not well understood. In this study, geochemical characteristics of total organic carbon (TOC), major, trace and rare earth elements (REEs) of thirty black rock series samples from a newly-cut roadside outcrop (Zhenning section) in Southern Guizhou, Southwest China are systematically investigated to examine provenance, paleoredox conditions, paleoclimate, paleoproductivity and sedimentary rate, and further to explore their influence on organic matter enrichment. Results show that TOC contents of the investigated samples range from 0.90% to 2.83%, with an average of 1.45%, with TOC variations being in accord with the stratigraphic cyclicity. These data also indicate that the target black rock series were deposited in a combination of continental island arc and active continental margin tectonic setting that exhibited moderate weathering, oxic/dysoxic oxygen levels, hot and arid to semiarid climate, and a higher sedimentary rate. Multiple paleoredox indicators (e.g., Ni/Co, V/Cr, U/Th and V/(V + Ni) ratios), together with slightly negative Ce anomalies and EFU-EFMo covariation, totally suggest an oxic/dysoxic water environment, which is usually considered unfavorable for organic matter preservation. Average (La/Yb)N ratios (1.41) reflect a higher sedimentary rate, resulting in shortening the exposure time of organic matter in the degradation region of aerobic bacteria under oxic/dysoxic conditions. Of the three factors that could affect organic matter enrichment, including paleoproductivity, paleoredox conditions and sedimentary rate, the relatively high paleoproductivity indicated by the relatively high TOC contents appears to be the dominant factor. In contrast, the other two factors, i.e., paleoredox conditions and the rate of sedimentation play relatively less significant roles. Based on these factors, an enrichment model of organic matter for the black rock series in Southern Guizhou Depression is established. These findings also contribute to constraining the sedimentary environment in such a setting and further deepen our understanding of the potential shale gas resources of the Southern Guizhou Province.
Geodynamics and Oil and Gas Potential of the Yenisei-Khatanga Basin (Polar Siberia)
Authors: Vernikovsky Valery , Shemin Georgy , Deev Evgeny , Metelkin Dmitry , Matushkin Nikolay , Pervukhina Natalia
Published: November 2018

The geodynamic development of the north–western (Arctic) margin of the Siberian craton is comprehensively analyzed for the first time based on our database as well as on the analysis of published material, from Precambrian-Paleozoic and Mesozoic folded structures to the formation of the Mesozoic-Cenozoic Yenisei-Khatanga sedimentary basin. We identify the main stages of the region’s tectonic evolution related to collision and accretion processes, mainly subduction and rifting. It is demonstrated that the prototype of the Yenisei-Khatanga basin was a wide late Paleozoic foreland basin that extended from Southern Taimyr to the Tunguska syneclise and deepened towards Taimyr. The formation of the Yenisei-Khatanga basin, as well as of the West-Siberian basin, was due to continental rifting in the Permian-Triassic. The study describes the main oil and gas generating deposits of the basin, which are mainly Jurassic and Lower Cretaceous mudstones. It is shown that the Lower Cretaceous deposits contain 90% of known hydrocarbon reserves. These are mostly stacked reservoirs with gas, gas condensate and condensate with rims. The study also presents data on oil and gas reservoirs, plays and seals in the Triassic, Jurassic and Cretaceous complexes.
Paddlewheelite, a New Uranyl Carbonate from the Jáchymov District, Bohemia, Czech Republic
Authors: Olds Travis A. , Plášil Jakub , Kampf Anthony R. , Dal Bo Fabrice , Burns Peter C.
Published: November 2018

Paddlewheelite, MgCa5Cu2[(UO2)(CO3)3]4·33H2O, is a new uranyl carbonate mineral found underground in the Svornost mine, Jáchymov District, Bohemia, Czech Republic, where it occurs as a secondary oxidation product of uraninite. The conditions leading to its crystallization are complex, likely requiring concomitant dissolution of uraninite, calcite, dolomite, chalcopyrite, and andersonite. Paddlewheelite is named after its distinctive structure, which consists of paddle-wheel clusters of uranyl tricarbonate units bound by square pyramidal copper “axles” and a cubic calcium cation “gearbox.” Paddle wheels share edges with calcium polyhedra to form open sheets that are held together solely by hydrogen bonding interactions. The new mineral is monoclinic, Pc, a = 22.052(4), b = 17.118(3), c = 19.354(3) Å, β = 90.474(2)°, V = 7306(2) Å3 and Z = 4. Paddlewheelite is the second-most structurally complex uranyl carbonate mineral known after ewingite and its structure may provide insights into the insufficiently described mineral voglite, as well as Cu–U–CO3 equilibrium in general.
Determination of Metals Content in Wine Samples by Inductively Coupled Plasma-Mass Spectrometry
Authors: Płotka-Wasylka Justyna , Frankowski Marcin , Simeonov Vasil , Polkowska Żaneta , Namieśnik Jacek
Published: November 2018

Knowledge about the metal content of wine is very important, for many reasons. Depending on the element, its quantity varies in wine from ng/L to mg/L. Despite the fact that metals are not directly connected to the taste and aroma of the wine, their content should be determined and controlled, because excess is undesirable, and in some cases prohibited, due to potential toxicity. Several analytical procedures for metal determination are applied. However, due to sensitivity, low limit of detection and speed of analysis, inductively coupled plasma-mass spectrometry (ICP-MS) is one of the most frequently used techniques. The aim of this study was to reveal specific relationships between the wine samples or between the chemical variables in order to classify the wines according to their metal content by application of chemometric analysis. For metals content determination, two techniques, ICP-MS and inductively coupled plasma-optical emission spectrometry (ICP-OES), were applied. Data obtained showed that none of the wine samples surpassed the toxic levels reported for metals in the literature, thus, these wines appeared to be safe as regards the risk associated with the potentially toxic metals intake. However, specific correlations between metals and specific aspects of the wines themselves have been found.
Analytical Profiling of Proanthocyanidins from Acacia mearnsii Bark and In Vitro Assessment of Antioxidant and Antidiabetic Potential
Authors: Chen Xiao , Xiong Jia , Huang Shenlin , Li Xun , Zhang Yu , Zhang Liping , Wang Fei
Published: November 2018

The proanthocyanidins from ethanol extracts (80%, v/v) of Acacia mearnsii (A. mearnsii) bark on chemical-based and cellular antioxidant activity assays as well as carbolytic enzyme inhibitory activities were studied. About 77% of oligomeric proanthocyanidins in ethanol extracts of A. mearnsii bark were found by using normal-phase HPLC. In addition, HPLC-ESI-TOF/MS and MALDI-TOF/TOF MS analyses indicated that proanthocyanidins from A. mearnsii bark exhibited with a degree of polymerization ranging from 1 to 11. These results of combined antioxidant activity assays, as well as carbolytic enzyme inhibitory activities of proanthocyanidins from A. mearnsii bark, indicated an encouraging antioxidant capacity for the high polyphenol content and a potential for use as alternative drugs for lowering the glycemic response.
In Silico Prediction of O6-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods
Authors: Sun Guohui , Fan Tengjiao , Sun Xiaodong , Hao Yuxing , Cui Xin , Zhao Lijiao , Ren Ting , Zhou Yue , Zhong Rugang , Peng Yongzhen
Published: November 2018

O6-methylguanine-DNA methyltransferase (MGMT), a unique DNA repair enzyme, can confer resistance to DNA anticancer alkylating agents that modify the O6-position of guanine. Thus, inhibition of MGMT activity in tumors has a great interest for cancer researchers because it can significantly improve the anticancer efficacy of such alkylating agents. In this study, we performed a quantitative structure activity relationship (QSAR) and classification study based on a total of 134 base analogs related to their ED50 values (50% inhibitory concentration) against MGMT. Molecular information of all compounds were described by quantum chemical descriptors and Dragon descriptors. Genetic algorithm (GA) and multiple linear regression (MLR) analysis were combined to develop QSAR models. Classification models were generated by seven machine-learning methods based on six types of molecular fingerprints. Performances of all developed models were assessed by internal and external validation techniques. The best QSAR model was obtained with Q2Loo = 0.83, R2 = 0.87, Q2ext = 0.67, and R2ext = 0.69 based on 84 compounds. The results from QSAR studies indicated topological charge indices, polarizability, ionization potential (IP), and number of primary aromatic amines are main contributors for MGMT inhibition of base analogs. For classification studies, the accuracies of 10-fold cross-validation ranged from 0.750 to 0.885 for top ten models. The range of accuracy for the external test set ranged from 0.800 to 0.880 except for PubChem-Tree model, suggesting a satisfactory predictive ability. Three models (Ext-SVM, Ext-Tree and Graph-RF) showed high and reliable predictive accuracy for both training and external test sets. In addition, several representative substructures for characterizing MGMT inhibitors were identified by information gain and substructure frequency analysis method. Our studies might be useful for further study to design and rapidly identify potential MGMT inhibitors.
Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells
Authors: Jung Hye-Uk , Lee Jeong-Hun , Chung Kyung-Sook , Hong Joo Young , Choi Jung-Hye , Kim Soo-Dong , Roh Eun Joo , Shin Kye Jung , Lee Kyung-Tae
Published: November 2018

We previously reported that 5-[4-(4-fluorophenoxy) phenyl] methylene-3-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride (KSK05104) has potent, selective and metabolically stable IKKβ inhibitory activities. However, the apoptosis-inducing of KSK05104 and its underlying mechanism have not yet been elucidated in human colon cancer cells. We show that KSK05104 triggered apoptosis, as indicated by externalization of Annexin V-targeted phosphatidylserine residues in HT-29 and HCT-116 cells. KSK05104 induced the activation of caspase-8, -9, and -3, and the cleavage of poly (ADP ribose) polymerase-1 (PARP-1). KSK05104-induced apoptosis was significantly suppressed by pretreatment with z-VAD-fmk (a broad caspase inhibitor). KSK05104 also induced release of cytochrome c (Cyt c), apoptosis inducing factor (AIF), and endonuclease G (Endo G) by damaging mitochondria, resulting in caspase-dependent and -independent apoptotic cell death. KSK05104 triggered endoplasmic reticulum (ER) stress and changed the intracellular calcium level ([Ca2+]i). Interestingly, treatment with KSK05104 activated not only ER stress marker proteins including inositol-requiring enzyme 1-alpha (IRE-1α) and protein kinase RNA-like endoplasmic reticulum kinase (PERK), but also μ-calpain, and caspase-12 in a time-dependent manner. KSK05104-induced apoptosis substantially decreased in the presence of BAPTA/AM (an intracellular calcium chelator). Taken together, these results suggest that mitochondrial dysfunction and ER stress contribute to KSK05104-induced apoptosis in human colon cancer cells.
Applications of Metal-Organic Frameworks in Food Sample Preparation
Authors: Manousi Natalia , Zachariadis George A. , Deliyanni Eleni A. , Samanidou Victoria F.
Published: November 2018

Food samples such as milk, beverages, meat and chicken products, fish, etc. are complex and demanding matrices. Various novel materials such as molecular imprinted polymers (MIPs), carbon-based nanomaterials carbon nanotubes, graphene oxide and metal-organic frameworks (MOFs) have been recently introduced in sample preparation to improve clean up as well as to achieve better recoveries, all complying with green analytical chemistry demands. Metal-organic frameworks are hybrid organic inorganic materials, which have been used for gas storage, separation, catalysis and drug delivery. The last few years MOFs have been used for sample preparation of pharmaceutical, environmental samples and food matrices. Due to their high surface area MOFs can be used as adsorbents for the development of sample preparation techniques of food matrices prior to their analysis with chromatographic and spectrometric techniques with great performance characteristics.
Purification, Preliminary Structure and Antitumor Activity of Exopolysaccharide Produced by Streptococcus thermophilus CH9
Authors: Sun Naxin , Liu Huiping , Liu Shaojuan , Zhang Xinyuan , Chen Pei , Li Weihong , Xu Xiangxin , Tian Wentan
Published: November 2018

In the present study, the preliminary structure and in vitro antitumor activity of three exopolysaccharides (EPSs) from Streptococcus thermophilus CH9 were investigated. Then, three purified fractions of EPS-1a, EPS-2a, and EPS-3a were obtained by chromatography using DEAE-52 cellulose and Sephadex G-100, respectively. The average molecular weight of EPS-1a, EPS-2a, and EPS-3a, were 1.80 × 106, 1.06 × 106 and 1.05 × 106. The monosaccharide composition of EPS-3a was dramatically different from the others. The EPS-1a and EPS-2a were mainly composed of mannose, in a ratio of 69.82% and 57.09%, respectively, while EPS-3a was mainly composed of glucose (63.93%), without mannose. In addition, the surface morphology observed suggested that there were protein particles on the sugar chain of EPS-3a and EPS-3a was a protein-containing polysaccharide. Furthermore, EPS-3a exhibited higher antitumor activity against human liver cancer HepG2 cells in vitro. The antitumor activity of EPS-3a in HepG2 cells was associated with cell apoptosis. HE staining and Hoechst 33342 staining showed that with the treatment of EPS-3a, HepG2 cells had typical morphological changes. Flow cytometry analysis showed that the cell cycle was arrested at G0/G1 phase.