bluuebunny/crossref_metadata_2025 huggingface dataset:
ИНФОРМАТИВНОСТЬ МОДИФИЦИРОВАННОЙ ПУНКЦИОННОЙ БИОПСИИ ПРИ УЗЛОВЫХ
ЗАБОЛЕВАНИЯХ ЩИТОВИДНОЙ ЖЕЛЕЗЫ В УСЛОВИЯХ ПОЛИКЛИНИЧЕСКОГО ЗВЕНА
Authors: Никитина О. М. , Кондрахов А. В. , Киселева Т. П.
Published: July 2023

ЦЕЛЬ: оценить информативность тонкоигольной аспирационной биопсии (ТАБ) узловых образований

щитовидной железы (ЩЖ) под ультразвуковым исследованием (УЗИ) и контролем с модификацией на современном этапе в условиях амбулаторно-диагностической поликлиники.

МАТЕРИАЛЫ И МЕТОДЫ: на базе амбулаторно-диагностического отделения Эндокринологического

центра ГАУЗ СО «ГКБ№40» хирургами/эндокринологами в 2021 году проведено 3901тонкоигольная аспирационная биопсия (ТАБ) под ультразвуковым контролем. Забор материала осуществлялся двумя специалистами хирургом /эндокринологом и врачом ультразвуковой диагностики. Основными отличительными

особенностями проведения манипуляции явились: подвод иглы к капсуле узла под контролем ультразвукового датчика в поперечной плоскости сканирования; специалист удерживал иглу за основание

большим и указательным пальцами (рука как точка опоры, удерживающая шприц). Материал забирался

за один проход иглы, а извлечение иглы из щитовидной железы проводилось только после отсоединения

баллона шприца.

РЕЗУЛЬТАТЫ: в цитологическом исследовании использовалась окраска мазков-аспиратов

по Романовскому-Гимза и классификация по Betesda (2011). Информативность материала составила 98,69%

(3850). Доброкачественные образования (I группа) были выявлены в 3538 (90,69%), злокачественные

образования (II группа) отмечались в 247 (6,33%). Проанализированы данные I группы: коллоидный зоб

1808 (463%), клеточно-паренхиматозный зоб 132 (3,38%), аутоиммунный тиреоидит 362 (9,27%), коллоидноклеточный зоб 15 (0,38%), киста 230 (5,89%), коллоидно-кистозный зоб 493 (12,63%), аденоматоз 221 (5,66%).

По результатам II группы: атипия клеток составила 47 (1,2%), папиллярный рак 57 (1,46%), папиллярный

рак на фоне аутоиммунного тиреоидита 4 (0,10%), медуллярный рак 3 (0,07%), фолликулярно-папиллярный

рак 27 (0,69%). По данным гистологического исследования аденомы составили 75%, рак (фолликулярный, папиллярный, фолликулярно-папиллярный) 20%, различные формы (коллойдный зоб, аутоиммунный тиреоидит) 5%. По последним данным зарубежных авторов 2022г в ретроспективном исследовании

195 пункционных биопсий традиционным методом узловые образования выявлены у 179 (91,7%), из которых 122 (62,5%) были классифицированы как доброкачественные, 50 (25,6%) фолликулярные и 7 (3,6%)

злокачественные. Результаты были неинформативные для 16 (8,3%) узлов.

ВЫВОДЫ: данный диагностический метод с модификацией может быть проведен в условиях поликлинического звена клиницистом (хирургом/эндокринологом), владеющим навыками выполнения ТАБ узлов

под УЗИ контролем, что ведет к залогу успешного диагностического поиска при заболевании щитовидной

железы.
ГОРМОНАЛЬНЫЙ И МЕТАБОЛИЧЕСКИЙ СТАТУС У ДЕВОЧЕК-ПОДРОСТКОВ С ОЖИРЕНИЕМ
И НАРУШЕНИЕМ МЕНСТРУАЛЬНОГО ЦИКЛА
Authors: Лискина А. С. , Колбасина О. Е.
Published: July 2023

ЦЕЛЬ: охарактеризовать клинические, метаболические и гормональные особенности девочек-подростков с ожирением и нарушением менструального цикла (НМЦ).

МАТЕРИАЛЫ И МЕТОДЫ: в исследование включены 80 девочек-подростков с ожирением,

не имеющих эндокринных и тяжелых соматических заболеваний. Девочки разделены на 2 группы:

1 группа (40 человек) -с НМЦ, 2 группа (40 человек)–без НМЦ. Ожирение диагностировано при индексе массы тела (ИМТ) > 2SD. Включение в группы проводилось через 1 год и более после старта менархе. Оценка степени гирсутизма проводилась по шкале Ферримена-Галлвея. Исследования

углеводного и липидного обмена, рассчитан индекс инсулинорезистентности HOMA; Лабораторные исследования в плазме крови: уровень тиреотропного гормона(ТТГ), свободного тироксина(Т4 св.),общего

тестостерона(Т общ),пролактина(ПРЛ),индекса свободных андрогенов (ИСА),антимюллерового гормона (АМГ),17-0Н прогестерона(17-ОНП),лютенизирующего гормона(ЛГ), фолликулостимулирующего

гормона(ФСГ),эстрадиола(Е2) на 3-5 день цикла.

Статистическая обработка- программа JAMOVI. Сравнительные данные представлены в виде медиан:

Ме1-1 группа, Ме2- 2 группа.

РЕЗУЛЬТАТЫ: средний возраст старта менархе в исследуемых группах сопоставим. Характер

НМЦ: 53% олигоменорея, 47% вторичная аменорея. Различий по степени ожирения не было: SDS ИМТ

Ме12,9/Ме22,94, р= 0,459. Гирсутное число в группах сопоставимо Ме15.0/Ме24.0, р=0,293. Достоверно

выше в 1 группе: нарушение толерантности к глюкозе (1 гр. 15%/ 2 гр. 2,5%, р=0,048), гипертриглицеридемия Ме11.61/Ме21.23, р= 0.037. Уровень в плазме крови холестерина, инсулина и инсулинорезистентность

в группах без достоверных различий.

В гормональном статусе, достоверно выше в группе с НМЦ уровни ЛГ Ме18.85/Ме26.70,р=0,008, Тобщ.

Ме11.90/Ме21.25, р=0,026, ИСА Ме114.5/Ме28.65, р=0,027, АМГ Ме16.61/Ме24.26, р=0,014. Во 2 группе достоверно выше уровень Е2Ме133.5/Ме245.0,р=0,012).Пламенные уровни ТТГ, Т4 св, ПРЛ, ФСГ, 17-0НП без

достоверных различий в группах.

ВЫВОДЫ:

1. Степень ожирения не оказывала влияние на выраженность нарушения менструального цикла.

2. В группе девочек с НМЦ и ожирением достоверно чаще встречались нарушение толерантности к углеводам и гипертриглицеридемия.

3. В гормональном статусе девочки с НМЦ и ожирением имели достоверно более высокие значения уровней ЛГ, АМГ и Т общ. за счет ИСА, что свидетельствует о роли умеренной гиперандрогенемии в генезе

становления менструального цикла.
ХАРАКТЕРИСТИКА НАРУШЕНИЙ УГЛЕВОДНОГО ОБМЕНА ПРИ ПЕРВИЧНОМ
ГИПЕРПАРАТИРЕОЗЕ
Authors: Бибик Е. Е. , Добрева Е. А. , Горбачева А. М. , Елфимова А. Р. , Еремкина А. К. , Мокрышева Н. Г.
Published: July 2023

ЦЕЛЬ: определить частоту и структуру патологии углеводного обмена у пациентов с первичным гиперпаратиреозом (ПГПТ).

МАТЕРИАЛЫ И МЕТОДЫ: проведено одноцентровое ретроспективное исследование взрослых пациентов с ПГПТ, включавшее анализ основных лабораторных показателей минерального и углеводного обмена до проведения хирургического лечения заболевания. Критериями исключения пациентов являлись:

отсутствие ремиссии ПГПТ или рецидив после паратиреоидэктомии в анамнезе; беременность, лактация.

Определялась частота и структура нарушений углеводного обмена при ПГПТ, исследованы потенциальные

взаимосвязи параметров различных видов метаболизма.

РЕЗУЛЬТАТЫ: в исследование вошли 367 пациентов с ПГПТ (медиана возраста 59 лет [52; 66]),

88% из которых имели симптомную форму заболевания. Частота нарушенной гликемии натощак составила 1,9% (95% ДИ [0,8%-4%]), нарушенной толерантности к глюкозе - 3,0% (95% ДИ [1,5-5]), сахарного

диабета 2 типа - 12% (95% ДИ [9-16]), случаев впервые выявленного сахарного диабета не было. У лиц

с нарушениями углеводного обмена индекс массы тела был статистически значимо выше, а концентрации остеокальцина - ниже (27,2 [24,2; 30,4] кг/м2

против 32,7 [28,1; 39,4] кг/м2

и 48,1 [34; 76,3] нг/мл против

33,1 [20,8; 51,8] нг/мл, соответственно, для всех параметров р<0,001). Среди всех больных сахарным диабетом 2 типа (n=45) 80% получали сахароснижающую терапию, в большинстве случаев (64%) включающую

метформин. На инсулинотерапии находились 5 человек (14%). В целом, на фоне получаемой терапии показатели углеводного обмена соответствовали целевым (медиана глюкозы натощак 6,5 [5,4; 7,4] ммоль/л,

гликированного гемоглобина 6,5 [6,0; 7,6] %). Диабетическая нефропатия диагностирована у 36,4% больных,

диабетическая ретинопатия - у 15,4%, симптомы диабетической дистальной нейропатии наблюдались

у 61,9% пациентов с ПГПТ. Отрицательные корреляции выявлены между показателями глюкозы плазмы

натощак, гликированного гемоглобина и остеокальцина (r1

=-0,243, p1

< 0,001; r2

=-0,328, p2

=0,009, соответственно), а также β-crossLaps (r3

=-0,255, p3

<0,001; r4

=-0,259, p4

=0,040, соответственно). Уровень гликемии

также ожидаемо зависел от состояния фильтрационной функции почек.

ВЫВОДЫ: среди пациентов с ПГПТ сахарный диабет 2 типа встречается чаще, чем в общей популяции.

Вероятной причиной этого может являться инсулинорезистентность. Взаимосвязь показателей гликемии

и метаболитов костной ткани позволяет предполагать их участие в процессах углеводного обмена.
ПЕРВИЧНЫЙ ГИПЕРПАРАТИРЕОЗ И АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ:
ЭПИДЕМИОЛОГИЧЕСКИЕ, КЛИНИЧЕСКИЕ И ПАТОФИЗИОЛОГИЧЕСКИЕ ВЗАИМОСВЯЗИ
Authors: Горбачева А. М. , Добрева Е. А. , Бибик Е. Е. , Елфимова А. Р. , Еремкина А. К. , Мокрышева Н. Г.
Published: July 2023

ЦЕЛЬ: исследовать патогенетические ассоциации между состоянием РААС и показателями минерального обмена, а также оценить частоту и характеристики артериальной гипертензии, в том числе, антигипертензивную терапию у пациентов с ПГПТ.

МАТЕРИАЛЫ И МЕТОДЫ: были проведены проспективное исследование активности РААС при ПГПТ;

анализ частоты АГ при ПГПТ и анализ антигипертензивной терапии на основании базы данных специализированного отделения.

РЕЗУЛЬТАТЫ: в исследование РААС включены 37 пациентов в активной фазе ПГПТ и 29 сопоставимых

здоровых добровольцев. У пациентов с ПГПТ активность ренина плазмы была значимо ниже, чем в группе сравнения (0,31 vs. 1,23 нг/мл*ч, р<0,001), а концентрация ангиотензина II - выше ( 40,2 vs. 23,7 пг/мл,

р<0,001). На 3-и сутки после паратиреоидэктомии (ПТЭ) указанные изменения сохранялись. Через год

после ПТЭ отмечалась нормализация всех показателей минерального обмена, отличий по показателям

РААС между группами также не отмечалось.

Из 585 пациентов с ПГПТ, госпитализированных в специализированное отделение НМИЦ эндокринологии, АГ диагностирована у 29,7% пациентов 18-49 лет, у 74% пациентов 50-65 лет и у 94% пациентов 66 лет

и старше. Шанс наличия АГ у пациента с ПГПТ возрастает в 7 раз после 53 лет и при ИМТ более 28,3 кг/м2

,

в 1,5 раза при концентрации фосфора более 0,91 ммоль/л, в 4 раза при СКФ менее 92 мл/мин/1,73 м2

и в 2 раза при концентрации бета-кросслапс менее 1,5 нг/мл. Пациенты, получавшие 3 и более антигипертензивных препарата, в отличии от лиц, не получавших антигипертензивную терапию, имели тенденцию к более высоким показателям кальциемии (2,69 vs. 2,61 ммоль/л, р = 0,03). У пациентов, принимавших ингибиторы РААС, показатели кальциемии были выше (2,68 vs. 2,62 ммоль/л, р=0,007), а СКФ ниже

(80 vs. 84 мл/мин/1,73 м2

, р=0,002), чем у пациентов, не получавших данные препараты.

ВЫВОДЫ: выявлена взаимосвязь между ПГПТ и компонентами РААС, также показана высокая частота

АГ среди пациентов с ПГПТ, выявлена ассоциация между гиперкальциемией и интенсивностью и составом

антигипертензивной терапии у пациентов с ПГПТ, патогенетические механизмы этих явлений требуют

уточнения.
Penyisihan Krom Dalam Limbah Cair Laboratorium Dengan Metode Adsorpsi dan Fitoremediasi
Authors: Indrawati Titik , Ningsih Nunung Isnaini Dwi , Sumarwanto Padya
Published: July 2023

The laboratory is one of the units that produce liquid waste which in addition to having infectious properties is also toxic, which if not managed properly will have the potential to damage the ernvironment and living things. Laboratory wastewater treatment is important because the treament and procurement of WWTPs that meet the requirements are very high cost, therefore it is neceessary to do research to find a simple but effective liquid waste treatment technology to reduce the level of liquid waste parameters, easy to make, using local materials, and the price is affordable. This study aims to determine the performance of sandston/gravel media, fly ash, vetiver (Vetiveria Zizanoides L), and the third mixture in reducing chromium content in laboratory wastewater by applying adsorption and phytoremediatioon methods. The liquid waste used is artificial waste made of Potassium Dichromate with a concentration of 15 mg/L. This research was conducted on a laboratory scale, using beaker. Adsorption experiments were carried out on fly ash and gravel media with weight variations of 20 g (2% w/v), 30 g (3% w/v) and 50 g (5% w/v). Phytoremediation experiments were carried out on vetiver (Vetiveria Zizanoides L) with variations in plant weight, namely 70 g (2% w/v), 170 g (3% w/v) and 200 g (5% w/v), while fro adsorption experiments the mixture of gravel and fly ash was carried our with variatons in weight of 40 g (2% w/v), 60 g (3% w/v) and 100 g (5% w/v) with ration of 1:1, respectively. The mixture of gravel, fly ash and plants was carried out in a ratio of 1:1:1 with a weight of 100 g each. Observations were made on chromium levels on day 1 and 15. The results showed that the removal of chromium levels in each adsorption experiment using gravel was an average of 0,32 mg/L, whilae adsorption using fly ash average 1.58 mg/L; 10.135 for fly ash; 2.00% for gravel, and 24.16% for vetiver. The decrease ini chromium levels with vetiver plants was 3,78 mg/L on average. The highest removal efficiency (RE) value of 76.64% occured in the adsorption and phytoremediation experiments using vetiver plants and a mixture of fly ash and gravel media a ratio (1:1:1) with each weight of 100 g (5% w/v).
The effects of curcumin on the fibrous envelope surrounding silicone implants in rats
Authors: Lee Jang Won , Jeong Seong Heum , Oh Seung Hyun , Kim Chung Hun
Published: July 2023

Background Capsular contracture is the most common serious breast surgery complication. The cause of capsular formation remains unknown, but chronic inflammation is commonly considered to cause excessive fibrosis. Curcumin has anti-inflammatory effects and thus can relieve the symptoms of inflammatory diseases, as demonstrated in animal studies. This study aimed to evaluate the effects of curcumin on the fibrous envelope covering silicone implants in a rat model.Methods Two solid 1.8-cm oval-shaped silicone implants were placed beneath both sides of the back in 20 Sprague-Dawley rats. The control group included 10 rats that were fed a normal diet (group A), while the experimental group (group B) included the remaining 10 rats that were fed ground curcumin. En bloc excision was conducted at 8 postoperative weeks. Capsular thickness and inflammatory cell distribution were examined using a fixed tissue sample.Results Gross findings and histologic differences between the groups were observed. The experimental group had a significantly lower mean total capsular thickness than the control group (177.4±31.4 μm vs. 145.9±32.5 μm, P=0.007). A significant decreasing tendency was found in several inflammatory cells in the experimental group (7,070±744.3/mm2 vs. 2,640±301.7/mm2, P=0.001).Conclusions Curcumin significantly reduced the inflammatory reaction, and will help to lower the risk of capsular contracture. Long-term studies are required to determine whether this hypothesis can provide a basis for a viable therapeutic strategy to reduce capsular contracture.
A wide depressed scar deformity treated with cutting wire and autologous fat graft: a case report
Authors: Kim Eun Chan , Jeong Hyun Gyo , Wee Syeo Young
Published: July 2023

Scars are still a challenging problem in medical practice, despite advancements in treatment modalities. Numerous treatment modalities, ranging from simple revision, Z-plasty, and W-plasty to laser treatments, have been used to treat scar deformities. However, for wide depressed scars, additional methods are needed to completely restore the contour of the depression caused by tissue adhesion. We report on the case of a 34-year-old woman with a wide depressed scar deformity on the left upper buttock and the encouraging results of an autologous fat graft injection technique that utilized a cutting wire to form a pocket for the fat graft site, while simultaneously resolving the adhesion caused by the tissue. This method is safe and easily reproducible, making it a useful addition to the surgeon’s toolkit when dealing with such lesions.
Case report of unusual complication following thread lifting: an obstructive stone in the parotid duct
Authors: Chung Yoon Kyu , Kim Min-Seok , Shin Jin Yong , Lee Nae-Ho , Park Ho Sung , Roh Si-Gyun
Published: July 2023

Advances in plastic surgery have included a shift toward less invasive procedures. To improve outcomes and avoid incisional surgery, numerous noninvasive face-lifting techniques have been studied. This includes thread-lifting, a technique that promises to correct facial aging with limited scarring, rapid recovery, and minimal complications. As the population ages, an increasing number of ordinary people in South Korea are undergoing thread lifting procedures for the purpose of rejuvenation. The procedure involves insertion of a thread under the skin into the subcutaneous tissue, using a long needle as a guide. Dents or barbs prevent the thread from slipping and provide uniform aggregation of soft tissue to create a new volume contour when the thread is lifted. This procedure has gained worldwide popularity and is frequently performed. However, some minor complications have been reported. In this paper, we report an unusual complication: an obstructive stone in the parotid (Stensen) duct after a thread-lifting procedure using nonabsorbable anchoring threads.
Comparison of the efficacy and safety between a new monophasic hyaluronic acid filler and a biphasic hyaluronic acid filler in correcting facial wrinkles
Authors: Lim Jung Soo , Kim Geon Hwi , Lee Jong Hun
Published: July 2023

Background The longstanding and common use of hyaluronic acid (HA) has driven the expanded development of various commercial HA fillers. However, differences in the components of these HA fillers lead to variations in their effect. We compared the in vivo safety and efficacy of biphasic HA (BHA) and a new monophasic HA (MHA) for improving facial wrinkles. We investigated differences in outcomes after their injection into nasolabial folds (NLFs) using the Wrinkle Severity Rating Scale (WSRS), patient satisfaction using the Global Aesthetic Improvement Scale (GAIS), and pain using a visual analog scale (VAS). We also performed a safety assessment of the two fillers.Methods This matched-pair, double-blind, randomized study compared the degree of temporal wrinkle improvement in the NLFs of 91 participants using the BHA filler versus the new MHA filler. Safety and efficacy were compared at 8 and 24 weeks.Results At 24 weeks after application, the average WSRS scores were 2.17±0.72 (BHA) and 2.07±0.71 (MHA) (P=0.034). The average GAIS scores, as measured by a treating investigator at 8 weeks and 24 weeks, were 0.94±0.76 (BHA) and 0.98±0.78 (MHA) at 8 weeks (P=0.181), and 0.44±0.64 (BHA) and 0.49±0.69 (MHA) at 24 weeks (P=0.103). The VAS pain score was 0 points at 30 minutes after filler application in both groups.Conclusions Both the BHA filler and the new MHA filler were safe and effective for improving facial wrinkles in NLFs, but the new MHA filler was more effective for the cosmetic improvement of wrinkle severity than the BHA filler.
Optimized procedure for high-throughput transcriptome profiling of small extracellular vesicles isolated from low volume serum samples
Authors: Vychytilova-Faltejskova Petra , Vilmanova Sara , Pifkova Lucie , Catela Ivković Tina , Mᶏdrzyk Marie , Jugas Robin , Machackova Tana , Kotoucek Jan , Sachlova Milana , Bohovicova Lucia , Stanek Teodor , Halamkova Jana , Kiss Igor , Slaby Ondrej
Published: July 2023

Objectives

Small extracellular vesicles (EVs) contain various signaling molecules, thus playing a crucial role in cell-to-cell communication and emerging as a promising source of biomarkers. However, the lack of standardized procedures impedes their translation to clinical practice. Thus, we compared different approaches for high-throughput analysis of small EVs transcriptome.

Methods

Small EVs were isolated from 150 μL of serum. Quality and quantity were assessed by dynamic light scattering, transmission electron microscopy, and Western blot. Comparison of RNA extraction efficiency was performed, and expression of selected genes was analyzed by RT-qPCR. Whole transcriptome analysis was done using microarrays.

Results

Obtained data confirmed the suitability of size exclusion chromatography for isolation of small EVs. Analyses of gene expression showed the best results in case of samples isolated by Monarch Total RNA Miniprep Kit. Totally, 7,182 transcripts were identified to be deregulated between colorectal cancer patients and healthy controls. The majority of them were non-coding RNAs with more than 70 % being lncRNAs, while protein-coding genes represented the second most common gene biotype.

Conclusions

We have optimized the protocol for isolation of small EVs and their RNA from low volume of sera and confirmed the suitability of Clariom D Pico Assays for transcriptome profiling.
Impact of cognitive abilities on performance in organic chemistry
Authors: Nedungadi Sachin , Shenoy Sunaina
Published: July 2023

The purpose of this study was to observe the relationship between students’ cognitive abilities and their performance in organic chemistry. We were interested in measuring whether some cognitive composites were more predictive than others on organic chemistry performance, whether group differences existed between males and females, and whether group differences existed between students with above and below average cognitive abilities. For Study 1 and Study 2, our participants included 48 and 60 sophomore organic chemistry students respectively. We used the Woodcock-Johnson Test of Cognitive Abilities-IV to measure cognitive composites. ACS organic chemistry exam scores and scores on an organic chemistry concept inventory were used to measure student performance. We ran a correlational analysis between the cognitive composites and organic chemistry scores, and t-tests for group comparisons. For Study 1, we found a significant moderate correlation between long-term retrieval and organic chemistry scores. For Study 2, we found a significant small to moderate correlation between comprehension knowledge and short-term working memory, with organic chemistry scores. We did not find any significant gender differences, except on comprehension knowledge. The differences between above average and below average cognitive abilities were only seen in relation to the concept inventory and not ACS exam scores.
On the dimensional indeterminacy of one-wave factor analysis under causal effects
Authors: VanderWeele Tyler J. , Batty Charles J. K.
Published: July 2023

It is shown, with two sets of indicators that separately load on two distinct factors, independent of one another conditional on the past, that if it is the case that at least one of the factors causally affects the other, then, in many settings, the process will converge to a factor model in which a single factor will suffice to capture the covariance structure among the indicators. Factor analysis with one wave of data then cannot distinguish between factor models with a single factor vs those with two factors that are causally related. Therefore, unless causal relations between factors can be ruled out a priori, alleged empirical evidence from one-wave factor analysis for a single factor still leaves open the possibilities of a single factor or of two factors that causally affect one another. The implications for interpreting the factor structure of psychological scales, such as self-report scales for anxiety and depression, or for happiness and purpose, are discussed. The results are further illustrated through simulations to gain insight into the practical implications of the results in more realistic settings prior to the convergence of the processes. Some further generalizations to an arbitrary number of underlying factors are noted. Factor analyses with one wave of data should themselves be interpreted as characterizing associations among indicators that may be present either due to conceptual relations or due to causal relations concerning the underlying construct phenomena.
The crystal structure of 4-(2,4-dichlorophenyl)-2-(4-fluorophenyl)-5-methyl-1H-imidazole, C16H11Cl2FN2
Authors: Li Yiting , Zhang Xiaochun , Weng Xingshang , Zhuang Xuewen
Published: July 2023

C16H11Cl2FN2, orthorhombic, Pbca (no. 61), a = 9.6732(3) Å, b = 15.5602(5) Å, c = 19.0881(6) Å, V = 2873.08(16) Å3, Z = 8, R
gt(F) = 0.0361, wR
ref(F
2) = 0.0958, T = 193 K.
Highly thermally conductive polyamide 6 composites with favorable mechanical properties, processability and low water absorption using a hybrid filling of short carbon fiber, flake graphite and expanded graphite
Authors: Fu Baomin , Yang Longlong , Xiang Wenwen , Zou Xiaoxuan , Dai Wenli
Published: July 2023

It is a challenge to maintain the mechanical properties and processability of thermally conductive polymer composites in the presence of high filling of heat conductive filler. An optimized hybrid filler system composed of flake graphite (FG), expanded graphite (EG) and short carbon fiber (CF) was introduced into PA6 matrix. The addition of EG to PA6 was found to be more effective in improving its thermal conductivity, while the addition of FG maintained favorable processability due to its lubrication effect. Furthermore, the hybrid filling of FG and EG has a synergistic effect on the enhancement of thermal conductivity. The ternary filling of FG, EG and CF produced highly heat conductive PA6 composites with high strength, favorable processability, and low water absorption. The thermal conductivity of 10CF/20FG/10EG/PA6 composite reached 3.45 W/m k, which is 12.3 times of pure PA6. Additionally, the flexural strength increased to 110 MPa, which is 37 % higher than that of pure PA6, and the water absorption was reduced to one quarter that of pure PA6.
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy
Authors: Hop Huynh Tan , Huy Tran Xuan Ngoc , Lee Hu Jang , Kim Suk
Published: July 2023

Bacteria of the genus Brucella cause brucellosis, one of the world's most common zoonotic diseases. A major contributor to Brucella's virulence is the ability to circumvent host immune defense mechanisms. Here, we find that the DNA‐binding protein Dps from Brucella is secreted within the macrophage cytosol, modulating host iron homeostasis and mediating intracellular growth of Brucella. In addition to dampening iron‐dependent production of reactive oxygen species (ROS), a key immune effector required for immediate bacterial clearance, cytosolic Dps mediates ferritinophagy activation to elevate intracellular free‐iron levels, thereby promoting Brucella growth and inducing host cell necrosis. Inactivation of the ferritinophagy pathway by Ncoa4 gene knockout significantly inhibits intracellular growth of Brucella and host cell death. Our study uncovers an unconventional role of bacterial Dps, identifying a crucial virulence mechanism used by Brucella to adapt to the harsh environment inside macrophages.
Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease
Authors: Mayer Carlotta , Nehring Sophie , Kücken Michael , Repnik Urska , Seifert Sarah , Sljukic Aleksandra , Delpierre Julien , Morales‐Navarrete Hernán , Hinz Sebastian , Brosch Mario , Chung Brian , Karlsen Tom , Huch Meritxell , Kalaidzidis Yannis , Brusch Lutz , Hampe Jochen , Schafmayer Clemens , Zerial Marino
Published: July 2023

Hepatocytes form bile canaliculi that dynamically respond to the signalling activity of bile acids and bile flow. Little is known about their responses to intraluminal pressure. During embryonic development, hepatocytes assemble apical bulkheads that increase the canalicular resistance to intraluminal pressure. Here, we investigate whether they also protect bile canaliculi against elevated pressure upon impaired bile flow in adult liver. Apical bulkheads accumulate upon bile flow obstruction in mouse models and patients with primary sclerosing cholangitis (PSC). Their loss under these conditions leads to abnormally dilated canaliculi, resembling liver cell rosettes described in other hepatic diseases. 3D reconstruction reveals that these structures are sections of cysts and tubes formed by hepatocytes. Mathematical modelling establishes that they positively correlate with canalicular pressure and occur in early PSC stages. Using primary hepatocytes and 3D organoids, we demonstrate that excessive canalicular pressure causes the loss of apical bulkheads and formation of rosettes. Our results suggest that apical bulkheads are a protective mechanism of hepatocytes against impaired bile flow, highlighting the role of canalicular pressure in liver diseases.
Effects of aromatase inhibitor therapy on adiposity and cardiometabolic health in postmenopausal women: a controlled cohort extension study
Authors: Cheung Yee-Ming M , Hoermann Rudolf , Van Karen , Wu Damian , Healy Jenny , Halim Bella , Raval Manjri , McGill Maria , Al-Fiadh Ali , Chao Michael , White Shane , Yeo Belinda , Zajac Jeffrey D , Grossmann Mathis
Published: July 2023

Purpose

We previously demonstrated that 12 months of aromatase inhibitor (AI) treatment was not associated with a difference in body composition or other markers of cardiometabolic health when compared to controls. Here we report on the pre-planned extension of the study. The pre-specified primary hypothesis was that AI therapy for 24 months would lead to increased visceral adipose tissue (VAT) area when compared to controls.

Methods

We completed a 12-month extension to our prospective 12-month cohort study of 52 women commencing AI treatment (median age 64.5 years) and 52 women with breast pathology not requiring endocrine therapy (63.5 years). Our primary outcome of interest was VAT area. Secondary and exploratory outcomes included other measures of body composition, hepatic steatosis, measures of atherosclerosis and vascular reactivity. Using mixed models and the addition of a fourth time point, we increased the number of study observations by 79 and were able to rigorously determine the treatment effect.

Results

Among study completers (AI = 39, controls = 40), VAT area was comparable between groups over 24 months, the mean-adjusted difference was −1.54 cm2 (95% CI: −14.9; 11.9, P = 0.79). Both groups demonstrated parallel and continuous increases in VAT area over the observation period that did not diverge or change between groups. No statistically significant difference in our secondary and exploratory outcomes was observed between groups.

Conclusions

While these findings provide reassurance that short-to-medium-term exposure to AI therapy is not associated with metabolically adverse changes when compared to controls, risk evolution should be less focussed on the AI-associated effect and more on the general development of cardiovascular risk over time.
A metabolomics-based analysis of the metabolic pathways associated with the regulation of branched-chain amino acids in rats fed a high-fructose diet
Authors: Yu Yang , Hao Hairong , Kong Linghui , Zhang Jie , Bai Feng , Guo Fei , Wei Pan , Chen Rui , Hu Wen
Published: July 2023

Previous studies have shown that the elevated levels of circulating branched-chain amino acids (BCAAs) are associated with the development of insulin resistance and its complications, including obesity, type 2 diabetes, cardiovascular disease and some cancers. However, animal models that can mimic the metabolic state of chronically elevated BCAAs in humans are rare. Therefore, the aim of this study was to establish the above animal model and analyse the metabolic changes associated with high BCAA levels. Sixteen 8-week-old Sprague–Dawley (SD) rats were randomly divided into two groups and given either a high fructose diet or a normal diet. BCAA levels as well as blood glucose and lipid levels were measured at different time points of feeding. The mRNA expression levels of two key enzymes of BCAA catabolism, ACAD (acyl-CoA dehydrogenase) and BCKDH (branched-chain α-keto acid dehydrogenase), were measured by qPCR, and the protein expression levels of these two enzymes were analysed by immunohistochemistry. Finally, the metabolite expression differences between the two groups were analysed by Q300 metabolomics technology. Our study confirms that defects in the catabolic pathways of BCAAs lead to increased levels of circulating BCAAs, resulting in disorders of glucose and lipid metabolism characterized by insulin resistance by affecting metabolic pathways associated with amino acids and bile acids.
Spirituality and Academic Performance: Exploring the Interplay for Students
Authors: Napone Vitalian Christophere L. , Lagura Gladys L.
Published: July 2023

This study aimed to explore the association between students' spirituality level at Caraga State University and their academic performance. Spiritual health and life orientation were assessed using the Spiritual Health and Life Orientation Measure (SHALOM) developed by John Fisher, while academic performance was measured in terms of Grade-Point Average (GPA). A descriptive-correlational research design was employed, involving 366 randomly selected participants through stratified random sampling with colleges as strata. Descriptive statistics, including averages and percentages, were utilized to assess the participants' spirituality level and academic performance. Additionally, Pearson's R Correlation test was applied to investigate the relationship between spirituality and academic performance. The results indicated that the participants at Caraga State University generally exhibited good spirituality, with an average score of 4.23. Most students demonstrated very good academic performance. The study found a positive, yet weak correlation between students' spirituality and academic performance, which was not statistically significant, with a coefficient of 0.049 and a p-value of 0.347. This weak and insignificant relationship can be attributed to the majority of students having a consistently high level of spirituality. The findings suggest that promoting spirituality within the school environment remains beneficial, as it does not adversely impact education. Furthermore, spirituality appears to be non-discriminatory, as both academically-inclined and non-academically-inclined students place equal value and importance on spirituality. Therefore, fostering spirituality in the university setting may contribute positively to students' holistic development.
Mechanotransduction and Biomechanical Properties of Bone Tissue as a Basis for the Use of Intraosseous Osteopathic Techniques
Authors: Valeryevich Novoseltsev Svyatoslav , Germanovich Reshetnikov Alexey , Dmitrievich Vyunov Vladislav , Rasimovich Suleymanov Timur , Maksimovna Nefedova Anastasia , Grigorievich Solomatov Petr
Published: July 2023

The development and maintenance of bone mass is critical to movement, health, and quality of life. Bone mass is regulated by various factors, activation of biologically active substances, enzymes, including changes in mechanical load. The osteocyte network provides a wide-ranging load monitoring "network" that penetrates every cubic millimeter of bone tissue. Deformities or trauma create a limitation that can cause asymmetric bone growth, such as plagiocephaly. A deep understanding of the cellular mechanisms responsible for bone remodeling as well as bone mechanotransduction is essential for the development of effective exercise, osteopathic techniques, and pharmaceutical strategies to increase and/or prevent bone loss. This review summarizes current data on the main molecular mechanisms involved in bone mechanotransduction, which provides insight into bone tissue, methods of working with it, and points of application for correcting various dysfunctions to promote bone growth in length. This process is carried out by increasing the proliferation of chondrocytes and the activity of growth plates. This contributes to the correction of such consequences of intraosseous dysfunctions as the development of anatomical differences in the size of the lower extremities in children.
On the starting and operational transients at the core of the RMB based on 2D multigroup diffusion
Authors: Santos Rubens Souza
Published: July 2023

RMB is a multipurpose reactor to be built by CNEN. As a multipurpose facility, unlike a nuclear power plant, some operations may result in transients, whether during the movement of materials from remote irradiation, extraction of neutrons through beam holes, reactor starting up, control rod accident, etc. For that, a methodology to visualize some variables like neutron fluxes, temperatures, power, etc., was developed. In this one present some preliminary results based on multigroup diffusion theory, thermal hydraulics feedbacks, and numerical methods, systematized in the DINUCLE code. DINUCLE couples a numerical code of multigroup spatial kinetics, for calculations of the flux of neutrons in the core of reactors, with a numerical code for the analysis of thermo hydraulic transients in rods and plates, considering the refrigerant always single-phase. Use was made of a programming in VBA (Visual Basic for Applications) from Excel, for data visualization in the transient.
Influence of Gerda’s Character in Supporting Einar’s Transition into Lili in The Danish Girl Film
Authors: Herlinda Septi , Sa'diyah Sholikatus
Published: July 2023

This research aims to show how Gerda Wegener, as a supporting character in The Danish Girl film, could significantly contribute to the main character’s transition from Einar Wegener (male) to Lili Elbe (female) through Gerda’s character and personality depicted in the film. This research uses the descriptive qualitative method. The writer uses the theory of the Big Five personality factors, characterization, and altruism to support the analysis. This research shows that Gerda’s character and personality are the leading cause of the conflict that occurred in the film, on how the main character, Einar Wegener, overcame his gender dysphoria to transform into a woman named Lili Elbe fully. Based on the Big Five personality factors, this research discovered that; Gerda’s personality in agreeableness and openness are highly relatable in influencing Lili’s transition. Moreover, Gerda’s behavior in altruism is also found to be the main reason she chose to support the main character’s gender transition despite the massive loss upon her. In conclusion, Gerda Wegener, as a supporting character, played the most significant role in stirring the plot by her influence in supporting Einar Wegener’s gender transition. It also shows that someone can be so selfless regarding the person they adore. Finally, it gives a new perspective on how significant the role of supporting characters is in a film based on their character and personality.
دراسة تحليلية للحجج في البطولة الدولية لمناظرات الجامعات باللغة العربية بالدولة-قطر سنة 2015 م
Authors: Manurung Rico Andrian
Published: July 2023

يهدف البحث إلى الكشف عن أنماط الحجة وتحديد مستواها الواردة في كلمات المتناظرين في الجولة النهائية من البطولة الدولية الثالثة لمناظرات الجامعات باللغة العربية بالدوحة-قطر 2015 م على أساس المنهح الوصفي التحليلي بطريقة البحث المكتبي انطلاقا من نموذج ستيفن تولمين لعناصر الحجة الستة وهي؛ 1) الادعاء، 2) البيانات، 3) الضمان، 4) الدعم، 5) التصنيف، 6) الرد أو الاستثناء. وتوصل البحث إلى نتيجتين رئيسيتين: فالأولى أنه كان هناك نمطان من الحجة وهما: ا) نمط الحجة الأول (C-G-W-B) الذي تكرر أربع مرات، أولا: من المتحدث الأول لفريق الموالاة في الحجة حول حقوق الإنسان وثانيا: من المتحدث الثاني لفريق الموالاة في الحجة حول السياسة في المحدد الأول؛ وثالثا: من المتحدثة الأولى لفريق المعارضة في الحجة حول توجيه القضية الفلسطينية إلى جوهرها؛ ورابعا: من المتحدثة الثانية لفريق المعارضة في الحجة حول حق الأفراد في الحياة الكريمة وحول القضايا الاجتماعية. ب) نمط الحجة الثاني (C-G-W) الذي تكر ثلاث مرات. أولا: من المتحدث الثاني لفريق الموالاة في الحجة حول السياسة في المحدد الثاني؛ وثانيا: من المتحدث الثاني لفريق الموالاة في الحجة حول القانون؛ وثالثا: من المتحدثة الأولى لفريق المعارضة في الحجة حول التبادل الثقافي للقضية. والثانية أن مستوى الحجة حسب نمطها: ا) نمط الحجة الأول (C-G-W-B) حصل على درجة: "جيد جدا". ب) والنمط الثاني (C-G-W) حصل على درجة: "جيد".
The Use of Mā forms in Surah Yāsīn and its various translations
Authors: Hifni Ahmad , Ridha Muhammad Syahid , Irawan Herawati , Barri Muhammad Fathul
Published: July 2023

This research seeks to identify and introduce the function and meaning of mā and to describe techniques for translating it into Indonesian especially in the Qur'an. The method used is a qualitative method based on library research. The data sources used are the types of mā forms found in Surah Yāsīn and in the translation will be shown a comparison of the translations of the Lajnah Pentashihan Mushaf Al-Qur'an in 2019 and Lembaga Percetakan Al-Qur’an Raja Fahd in 1997. The results of this study state that There are five forms of the eight forms of mā in the Surah Yāsīn, totaling 32 data from 26 verses. The five forms are al-istifhāmiyyah with 1 data, namely in verse 22, al-mauṣūliyyah with 16 data, namely in verses 12, 35, 36, 42, 45, 47, 52, 54, 57, 64, 65, 71, and 76, al-masdariyyah has 1 data in verse 27, al-nāfiyyah has 12 data in verses 6, 15, 17, 28, 30, 46, 49, 67, and 69, and al-zaidah has 2 data in verses 11 and 82. As for the form of translation, al-istifhāmiyyah is often translated with interrogative sentences, al-mauṣūliyyah is translated as 'which', al-masdariyyah can be translated in noun form, al-nāfiyyah is mostly translated 'no', and mā al-zāidah is often not translated into Indonesian.
The Events of Friday Ta'addud in the Text of Min al-Mihnah wa al-Musibah Ta'addud al-Jumu'at bi al-Ghasibah by Sayyid Uthman bin Yahya al-'Alawi: A Historical Review
Authors: Zaelani Muhammad , Fadlan Muhammad Nida'
Published: July 2023

The purpose of this study is to analyze the text Min al-Mihnah wa al-Musibah Ta'addud al-Jumu'at bi al-Ghasibah by Sayyid Usman bin Yahya al-‘Alawi, which can be a valuable resource for a broader audience, and to uncover its main ideas. This study adopts the intellectual social history approach and focuses on the manuscript as the primary data source. The findings of this study show that the manuscript contains a fatwa issued by Sayyid Usman bin Abdullah bin Aqil bin Yahya al-‘Alawi regarding the occurrence of ta'addud jum'at in Palembang, and it covers twelve topics. In the manuscript, Sayyid Usman argues that the Friday prayer performed in Palembang was invalid according to the Shafi'i school, and he also explains that the Shafi'i school permit ta'addud jum'at under two conditions: necessity and emergency. After reviewing the situation, he concluded that ta'addud jum'at was not valid in Palembang.
Harf Ma'ani's Distinction and Its Application in Arabic-Indonesian Translation
Authors: Tsani Sulthon Farhan , Isman Ikhwanul Fitra , Ferdiansyah Farrel Arfiko
Published: July 2023

This article explain the influence of "harf ma'āni" in producing meaning in Arabic. Through the study of nahwiyah dilaliyah, researchers will examine various forms of sentences in Arabic such as fi'il madzi, fi'il mudhāri’, masdar, isim fā’il and so on whose meaning can change from the lexical meaning (dictionary) due to the inclusion of the harf al-ma 'ani. This study is important to see the various meanings of Arabic sentences that are juxtaposed with harf al-ma'ani. The method used in this research is a qualitative method (qualitative research) with library research (library research). The primary data source for this research is a number of Arabic texts taken from a book entitled Dalīl fī al-Tarjamah by Dr. Rofi'i. While secondary sources for this research were taken from various scientific literature such as books, journal articles, dictionaries, and various other literature related to this research topic. This study concludes that the lexical meanings of the forms fi'il mādhi, fi'il mudhāri’, masdar, and isim fā’il can change and even contradict each other due to the inclusion of the harf ma’āni that follows them. Arabic language reviewers, especially Arabic-Indonesian translators, must be able and thorough in observing changes in the meaning of a sentence due to the inclusion of harf ma’āni which form new meanings and even contradict each other with their lexical meanings.
Misrepresentation of Religious Tenet in Syed Waliullah’s Tree Without Roots [Lal Shalu]: An Islamic Overview
Authors: Uddin Mohammad Jashim
Published: July 2023

AbstractSyed Waliullah is one of the most versatile Muslim novelists in Bangladesh. Social reformation, awakening people about religion and satire against corruption are his main themes. He also identifies the peripheral community in his writings. His Tree Without Roots originally Lal Shalu in Bangla is the most popular novel for its multilevel portrayal of the Bengali Muslim community. The paper aims at focusing on how Islam and its followers are portrayed wrongly in Tree Without Roots because the novelist through the activities of Majeed wants to divert the mass Muslims from the Qur’anic guidelines to the man-made path for worldly benefits. It concentrates on the controversial protagonist Abdul Majeed who grasps the rural people especially the simple and innocent like women for his greater projection of power and hunger. As a part of his prosperity, Majeed deeply feels inside himself that women can be the most flexible and reliable field for smooth cultivation and experimental adventure. This paper has also traced the sources of the power of Majeed—the protagonist, that he uses to manipulate the villagers and to claim his influential position in Mahabbatpur – a fictional village of Bangladesh which was then East Pakistan. It has focused on the activities of the characters from an Islamic perspective. The paper believes that every Muslim should follow the instructions of Allah reviled in the Qur’an and the path shown in the Hadith by Prophet Muhammad (pbuh). Finally, the paper has found some ways the author has misrepresented Islam in his writing from a modernist perspective.
Islamic Values and Education in Sufiya Ahmed’s Secrets of the Henna Girl
Authors: Chaliza Annisa Nur , Djohar Hasnul Insani
Published: July 2023

This research examines how Sufiya Ahmed’s Secrets of Henna Girl challenges patriarchal practices by depicting the female character as struggling to fight for their rights through Islamic values and education. By using qualitative methods and close textual analysis, this research examines how the novel opposes to patriarchal culture and the misconception of Islam as a religion that supports discrimination against women. Indeed, the novel uses literary devices to portray patriarchal culture with the following aspects: the female characters experience patriarchal abuse by depicting men as Tiger King represents powerful men. Secondly, the female characters deal with patriarchal system by depicting women as witches representing powerful women. Thirdly, women experienced patriarchal abuse are depicted through the metaphor of glass vases and sacrificed lambs. Fourthly, the characters are depicted as a drama queen if they pursue their educations and careers. Although this novel is seemingly depicted women as the victims of patriarchal system, they are able to resist this system by using Islamic tenets and values, especially the Quran and hadiths. Furthermore, it is found that even though the female characters receive so many patriarchal practices, the novel can depict them as resisting patriarchy through education and Islamic values. Thus, the novel uses Qur’an, hadith, and Islamic teachings as a way to resist the misconception of Islam as a religion that supports discrimination against women.
Prison and Freedom in Nadia Hashimi’s A House Without Windows
Authors: Putratama Muhammad Raihansyah , Chusna Inayatul
Published: July 2023

This research aims to analyse a prison where the characters achieve their freedom, while outside the prison they get oppressed by the men. This research uses the freedom concept by Jean-Paul Sartre because of the relevancy behind the theory and the story. The corpus of this research is Nadia Hashimi’s A House Without Windows (2016). The study uses the existentialism theories from Jean-Paul Sartre and Representation theory by Stuart Hall to support the analysis. The result of this research shows a great contrast between the women when they were out of prison and when they were in prison. Outside the prison, they continue to experience oppression from various parties, while when they are in prison, they live more freely than when they were outside the prison. For the inmate, the definition of freedom itself shifts from the common definition. To be able to get freedom is not only in an open space, but it can also be in a prison where the space for movement is limited, but not by their actions and speech.