bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 4 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

XLSX file, 115K, Oligodendroglioma-specific genes.
Supplementary Figure 3 from FGFR4 Promotes Stroma-Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer
Authors: Liu Rui , Li Jingyi , Xie Ke , Zhang Tao , Lei Yunlong , Chen Yi , Zhang Lu , Huang Kai , Wang Kui , Wu Hong , Wu Min , Nice Edouard C. , Huang Canhua , Wei Yuquan
Published: April 2023

PDF file, 1780K, Proteomic analysis of RKO cells co-cultured with TAFs.
Supplementary Figure 8 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

PDF file, 1743K, p53 sequencing of Rb/Pten tumours and in vitro recombined Rb/Pten neurospheres.
Supplementary Figure 6 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

PDF file, 929K, Derivation and testing of a human sPNET-specific gene signature.
Supplementary Figure 4 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

PDF file, 828K, Tumour incidence in primary and grafted tumours depend on the initial genetic mutation.
Supplementary Figure 1 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

PDF file, 1557K, Expression patterns of tumours generated in a p53/PTEN/Rb background.
Supplementary Methods from Substance P Autocrine Signaling Contributes to Persistent HER2 Activation That Drives Malignant Progression and Drug Resistance in Breast Cancer
Authors: Garcia-Recio Susana , Fuster Gemma , Fernandez-Nogueira Patricia , Pastor-Arroyo Eva M. , Park So Yeon , Mayordomo Cristina , Ametller Elisabet , Mancino Mario , Gonzalez-Farre Xavier , Russnes Hege G. , Engel Pablo , Costamagna Domiziana , Fernandez Pedro L. , Gascón Pedro , Almendro Vanessa
Published: April 2023

PDF file, 290K.
Supplementary Figure 3 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 1303K, Evaluation of available material from patient #9. (a-b) Array CGH profiles of the primary tumor (a) and metastasis (peritoneal carcinomatosis) (b). Regarding the color bar codes please see legend to Supp. Fig. 2.
Supplementary Figure 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing
Authors: Heitzer Ellen , Auer Martina , Gasch Christin , Pichler Martin , Ulz Peter , Hoffmann Eva Maria , Lax Sigurd , Waldispuehl-Geigl Julie , Mauermann Oliver , Lackner Carolin , Höfler Gerald , Eisner Florian , Sill Heinz , Samonigg Hellmut , Pantel Klaus , Riethdorf Sabine , Bauernhofer Thomas , Geigl Jochen B. , Speicher Michael R.
Published: April 2023

PDF file - 1233K, Additional CTCs from patient #26. Individual CTC-integer number profiles from CTCs 05 (a), 24 (b), 25 (c), 28 (d).
Supplementary Figure 5 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: April 2023

PDF file - 450K, Phenotype of blood NK cells from stage III melanoma patients.
Supplementary Figure 1 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: April 2023

PDF file - 272K, Gating strategy of NK cells in total LN cell suspensions.
Supplementary Figure 4 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 1504K,(A, B) The indicated amounts of PKH- and PKH+ cells from A549 cells were transplanted into 21-day old nude mice
Supplementary Movie 1 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

MP4 file - 195K, SPION positive H2 cells at 24 hours
Supplementary Figure 1 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

PDF file - 355K, From human melanoma brain metastases to transfected cell line
Supplementary Table 1 from Ex Vivo Activation of CD56+ Immune Cells That Eradicate Neuroblastoma
Authors: Rujkijyanont Piya , Chan Wing Keung , Eldridge Paul W. , Lockey Timothy , Holladay Martha , Rooney Barbara , Davidoff Andrew M. , Leung Wing , Vong Queenie
Published: April 2023

PDF file - 57K, Characteristics of neuroblastoma cell lines
Supplementary Methods from MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Authors: Tovar Christian , Graves Bradford , Packman Kathryn , Filipovic Zoran , Xia Brian Higgins Mingxuan , Tardell Christine , Garrido Rosario , Lee Edmund , Kolinsky Kenneth , To Kwong-Him , Linn Michael , Podlaski Frank , Wovkulich Peter , Vu Binh , Vassilev Lyubomir T.
Published: April 2023

PDF file - 136K, Includes HTRF, cell growth/viability, apoptosis assays and biacore, crystal structure and animal studies. Also includes supplemental references.
Supplementary Figures S1-S9 from Cholesterol Loading and Ultrastable Protein Interactions Determine the Level of Tumor Marker Required for Optimal Isolation of Cancer Cells
Authors: Jain Jayati , Veggiani Gianluca , Howarth Mark
Published: April 2023

Supplementary Figures S1-S9 PDF file 2507K, Testing Fab monobiotinylation (S1); Relationship between Fab0.11 antibody concentration and number of antibodies bound per cell (S2); Cell recovery sensitivity was enhanced by twin biotin tags on the antibody (S3); Chemically biotinylated antibody also gave efficient cell isolation (S4); Effect of cholesterol on surface staining for HER2 (S5); Cholesterol loading and direct bead linkage enhanced the recovery even with lower affinity antibody (S6); Effect of individual changes on recovery of cells varying in HER2 expression (S7); Cholesterol loading and direct bead linkage enhanced isolation of cells expressing low levels of EpCAM (S8); Specificity of recovery of cancer cell-lines from blood (S9)
Supplementary Figure 4 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 74K, PD-1 or PD-L1 blockade increases immune activation of TILs in ID8 tumor.
Supplementary Figure 2 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 58K, Expression of PD-L1 and PD-1 in ID8 mice.
Supplementary Figure 1 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 78K, Gating strategy & representative stains of MDSC and Treg cells.
Supplementary Methods, Figures 1 - 9, Tables 1 - 2 from Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer
Authors: Wauters Elke , Sanchez-Arévalo Lobo Victor J. , Pinho Andreia V. , Mawson Amanda , Herranz Daniel , Wu Jianmin , Cowley Mark J. , Colvin Emily K. , Njicop Erna Ngwayi , Sutherland Rob L. , Liu Tao , Serrano Manuel , Bouwens Luc , Real Francisco X. , Biankin Andrew V. , Rooman Ilse
Published: April 2023

PDF file - 790K, S Table 1. Primary and secondary antibodies used in immunostaining and Western Blotting experiments S Table 2. Antibodies used for immunoprecipitation experiments S Table 3. Primers used in real time RT-PCR and PCR of the ChIP experiments S Figure 1: The expression pattern of Sirt1 and beta-catenin changes in Caerulein induced pancreatitis. S Figure 2: The expression pattern of Sirt1 and beta-catenin, but not Dbc1, changes in pancreatic duct ligation. S Figure 3: In an in vitro ADM model, Sirt1 undergoes transient changes in subcellular localisation without changes in expression levels. S Figure 4: Deletion of functional Sirt1 in Pdx1-Cre;Sirt1ex4lox/lox pancreas impacts on acinar cell differentiation during ADM. S Figure 5: Acinar cell differentiation is not altered during ADM in Sirt1 transgenic (SirtTg) pancreas. S Figure 6: Nicotinamide represses ADM of human cells in culture. S Figure 7: Sirt1 co-localizes and interacts with beta-Catenin in acinar cells. S Figure 8: Nicotinamide increases beta-catenin/Wnt signaling in ADM cultures. S Figure 9: Dbc1 expression is decreased in PDAC but not in chronic pancreatitis.
Supplementary Methods and Figure Legend from Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression
Authors: Lin Pei-Chun , Chiu Ya-Lin , Banerjee Samprit , Park Kyung , Mosquera Juan Miguel , Giannopoulou Eugenia , Alves Pedro , Tewari Ashutosh K. , Gerstein Mark B. , Beltran Himisha , Melnick Ari M. , Elemento Olivier , Demichelis Francesca , Rubin Mark A.
Published: April 2023

PDF file - 134K
Supplementary Movie 2 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

WMV file - 2.7MB, Condensed video of empty vector PCa cell breaching of vascular endothelium
Supplementary Figure 6 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 198KB, Validation of the PI3K Inhibitor LY294002 repressing Fra-1 and c-Jun expression in MDA-MB-231 and Hs578T TNBC cell lines.
Supplementary Movie 1 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

WMV file - 3MB, Condensed video of FT7+ PCa cell breaching of vascular endothelium
Supplementary Figure 4 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Authors: Barthel Steven R. , Hays Danielle L. , Yazawa Erika M. , Opperman Matthew , Walley Kempland C. , Nimrichter Leonardo , Burdick Monica M. , Gillard Bryan M. , Moser Michael T. , Pantel Klaus , Foster Barbara A. , Pienta Kenneth J. , Dimitroff Charles J.
Published: April 2023

PDF file - 178K, FT expression generates E-selectin-binding determinants on PCa cell glycoproteins and glycolipids
Supplementary Figure 1 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 41KB, Validation of ChIP-seq data by real-time PCR.
Supplementary Figure 6 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 263K, Supplementary Figure 6. Knockdown of SAC1, PI4KIIIbeta and GOLPH3.
Supplementary Methods and Materials from Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
Authors: Huang Shyhmin , Li Chunrong , Armstrong Eric A. , Peet Chimera R. , Saker Jarob , Amler Lukas C. , Sliwkowski Mark X. , Harari Paul M.
Published: April 2023

PDF file- 63KB, Supplementary Materials and Methods
Supplementary Figure 2 from Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
Authors: Huang Shyhmin , Li Chunrong , Armstrong Eric A. , Peet Chimera R. , Saker Jarob , Amler Lukas C. , Sliwkowski Mark X. , Harari Paul M.
Published: April 2023

PDF file - 51KB, MEHD7945A increases cell fraction in apoptotic sub-G0 phase.
Supplementary Table 2 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 56K, qPCR primer pairs
Supplementary Figure Legend from Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Authors: Akalay Intissar , Janji Bassam , Hasmim Meriem , Noman Muhammad Zaeem , André Fabrice , De Cremoux Patricia , Bertheau Philippe , Badoual Cécile , Vielh Philippe , Larsen Annette K. , Sabbah Michèle , Tan Tuan Zea , Keira Joan Herr , Ying Hung Nicole Tsang , Thiery Jean Paul , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 108K
Supplementary Figure S3 from Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity
Authors: Perret Rachel , Sierro Sophie R. , Botelho Natalia K. , Corgnac Stéphanie , Donda Alena , Romero Pedro
Published: April 2023

Supplementary Figure S3. T cell responses following adjuvanted peptide vaccination with or without IFA
Supplementary Figure S2 from Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity
Authors: Perret Rachel , Sierro Sophie R. , Botelho Natalia K. , Corgnac Stéphanie , Donda Alena , Romero Pedro
Published: April 2023

Supplementary Figure S2. Activation status of antigen-specific T cells following vaccination with and without adjuvants
Supplementary Figure S1 from Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity
Authors: Perret Rachel , Sierro Sophie R. , Botelho Natalia K. , Corgnac Stéphanie , Donda Alena , Romero Pedro
Published: April 2023

Supplementary Figure S1. T cell responses following peptide vaccination in combination with CpG
Supplementary Figure S2 from A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity
Authors: Yu Xiaofei , Guo Chunqing , Yi Huanfa , Qian Jie , Fisher Paul B. , Subjeck John R. , Wang Xiang-Yang
Published: April 2023

Supplementary Figure S2 PDF file - 71K,TLR5 expression has little effect on activation of NF-B and MAPKs in bone marrowderived DCs following adenovirus-mediated delivery of Flagrp170
Supplementary Figure 2 from A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
Authors: Zhang Xiaolei , Sun Ying , Pireddu Roberta , Yang Hua , Urlam Murali K. , Lawrence Harshani R. , Guida Wayne C. , Lawrence Nicholas J. , Sebti Saïd M.
Published: April 2023

PDF file - 6958K, Figure S2: STAT3-C inhibits the ability of S3I-1757 to suppress migration and invasion. MDA-MB-468 cells were transiently transfected with vector or STAT3C, plated either for migration (A) or invasion (B) and then treated with S3I-1757 as described in Methods. The cells were then processed for migration (A) and invasion (B) assays as described under Methods.
Supplementary Figure S1 from A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity
Authors: Yu Xiaofei , Guo Chunqing , Yi Huanfa , Qian Jie , Fisher Paul B. , Subjeck John R. , Wang Xiang-Yang
Published: April 2023

Supplementary Figure S1 PDF file - 85K, Flagrp170 stimulates enhanced activation of DCs
Supplementary Figure Legend from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 88K
Supplementary Table 2 from Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors
Authors: Hahn Maria A. , Li Arthur X. , Wu Xiwei , Yang Richard , Drew David A. , Rosenberg Daniel W. , Pfeifer Gerd P.
Published: April 2023

PDF file - 125KB, Gene ontology analysis for genes activated at least 2-fold in at least 2 out 4 tumors and not carrying bivalent promoter status in any of the normal mucosa samples.
Supplementary Figure 6 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 50K, Figure S6: Ex vivo comparison of vessel density in stroma vs tumor tissue. Using the Image Scope v7.1 regions of viable tumor were manually selected. 200�m micrometers were placed around the circumference of the tumor region perpendicular to the tumor edge. A second manually selected region was drawn around the perimeter of the micrometers. This effectively segments the entire tissue section into three regions of interest; the tumor, the edge within 200�m of the tumor and the distant stromal region. The Aperio (Vista, CA, USA) microvessel algorithm v1.0 was used with the following parameters (smoothing 2; dark threshold160; light threshold 210; regioning 6; completion 7) to identify the vascular density which was defined as the vessel area divided by total area (�m2).
Supplementary Figure Legends from Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors
Authors: Hahn Maria A. , Li Arthur X. , Wu Xiwei , Yang Richard , Drew David A. , Rosenberg Daniel W. , Pfeifer Gerd P.
Published: April 2023

PDF file - 89KB
Supplementary Figure 5 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 43K, Figure S5: Relation between tumor growth and pH for all 5 mice. Data for all 5 mice were parsed as in figure 2D wherein the growth (in pixels) and pH were calculated every 22.5o of arc. These data show that growth increased with decreasing pH for all animals, and that there was a threshold of pH above which no growth occurred. Lines represent the trend below threshold for each mouse.
Supplementary Figure 3 from Ly49 Family Receptors Are Required for Cancer Immunosurveillance Mediated by Natural Killer Cells
Authors: Tu Megan M. , Mahmoud Ahmad Bakur , Wight Andrew , Mottashed Amelia , Bélanger Simon , Rahim Mir Munir A. , Abou-Samra Elias , Makrigiannis Andrew P.
Published: April 2023

PDF file - 40KB, Decreased cytotoxicity but not IFN-gamma production in NKCKD mice.
Supplementary Figure 10 from Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Authors: Estrella Veronica , Chen Tingan , Lloyd Mark , Wojtkowiak Jonathan , Cornnell Heather H. , Ibrahim-Hashim Arig , Bailey Kate , Balagurunathan Yoganand , Rothberg Jennifer M. , Sloane Bonnie F. , Johnson Joseph , Gatenby Robert A. , Gillies Robert J.
Published: April 2023

PDF file - 81K, Figure S10: Inhibition of tumor growth as a result of NaHCO3 treatment. Tumor area was measured at days 4 and 13 by fluorescent pixel number using Image-Pro Plus v6.2. The mean growth illustrated a significant increase in size of the control tumor over 2 weeks (p<0.033). In contrast, following bicarbonate treatment, the size of the tumor significantly decreased (p<0.003). Comparing control vs. bicarbonate mice on day 13 showed a significant difference (p<0.028) using three different statistical approaches.
Supplementary Figure 1 from Ly49 Family Receptors Are Required for Cancer Immunosurveillance Mediated by Natural Killer Cells
Authors: Tu Megan M. , Mahmoud Ahmad Bakur , Wight Andrew , Mottashed Amelia , Bélanger Simon , Rahim Mir Munir A. , Abou-Samra Elias , Makrigiannis Andrew P.
Published: April 2023

PDF file - 39KB, Defective control of B16F10-derived flank tumors in NKCKD is MHC-I-dependent.
Supplementary Tables 1 through 3 from Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression
Authors: Palmer Trenis D. , Martínez Carlos H. , Vasquez Catalina , Hebron Katie E. , Jones-Paris Celestial , Arnold Shanna A. , Chan Susanne M. , Chalasani Venu , Gomez-Lemus Jose A. , Williams Andrew K. , Chin Joseph L. , Giannico Giovanna A. , Ketova Tatiana , Lewis John D. , Zijlstra Andries
Published: April 2023

PDF - 67K, Demographic information of patients that underwent RRP at the London Regional Cancer Program between 1994 and 1998 (S1); Pathological and clinical outcomes of patients that underwent RRP at the London Regional Cancer Program between 1994 and 1998 (S2); Demographic information of patients that developed metastasis during follow up at the London Regional Cancer Program between 1994 and 1998 (S3).
Supplementary Figure Legend from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells
Authors: Michels Sebastian , Trautmann Marcel , Sievers Elisabeth , Kindler Dagmar , Huss Sebastian , Renner Marcus , Friedrichs Nicolaus , Kirfel Jutta , Steiner Susanne , Endl Elmar , Wurst Peter , Heukamp Lukas , Penzel Roland , Larsson Olle , Kawai Akira , Tanaka Shinya , Sonobe Hiroshi , Schirmacher Peter , Mechtersheimer Gunhild , Wardelmann Eva , Büttner Reinhard , Hartmann Wolfgang
Published: April 2023

PDF file - 17K
Supplementary Figure 1 from SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells
Authors: Michels Sebastian , Trautmann Marcel , Sievers Elisabeth , Kindler Dagmar , Huss Sebastian , Renner Marcus , Friedrichs Nicolaus , Kirfel Jutta , Steiner Susanne , Endl Elmar , Wurst Peter , Heukamp Lukas , Penzel Roland , Larsson Olle , Kawai Akira , Tanaka Shinya , Sonobe Hiroshi , Schirmacher Peter , Mechtersheimer Gunhild , Wardelmann Eva , Büttner Reinhard , Hartmann Wolfgang
Published: April 2023

PDF file - 70K, As an indirect proof of specific SRC-related action of dasatinib in synovial sarcoma cells, CME-1 did not display any significant effects upon dasatinib treatement after siRNA-mediated SRC-knockdown.
Supplementary Figure 4 from Identification of Inherited Genetic Variations Influencing Prognosis in Early-Onset Breast Cancer
Authors: Rafiq Sajjad , Tapper William , Collins Andrew , Khan Sofia , Politopoulos Ioannis , Gerty Sue , Blomqvist Carl , Couch Fergus J. , Nevanlinna Heli , Liu Jianjun , Eccles Diana
Published: April 2023

PDF file - 52K, Regional plot of p-values arising from cox-proportional hazard models, 250 kb either side of the rs2774307 variant in stage-1. P-values are from imputed data alone.
Supplementary Figure S6 from IFN-γ–Mediated Downregulation of LXA4 Is Necessary for the Maintenance of Nonresolving Inflammation and Papilloma Persistence
Authors: Wang Chunhui , Xiao Mingjie , Liu Xiaoman , Ni Chen , Liu Jianhong , Erben Ulrike , Qin Zhihai
Published: April 2023

Supplementary Figure S6 PDF file - 1652K, IFN� inhibited LXA4 generation and 15-LOX expression in vitro
Supplementary Figure Legends from IFN-γ–Mediated Downregulation of LXA4 Is Necessary for the Maintenance of Nonresolving Inflammation and Papilloma Persistence
Authors: Wang Chunhui , Xiao Mingjie , Liu Xiaoman , Ni Chen , Liu Jianhong , Erben Ulrike , Qin Zhihai
Published: April 2023

Supplementary Figure Legends PDF file - 92K, Legends for supplementary Table 1, Fig.S1, S2, S3, S4, S5 and S6
Supplementary Figure Legend from Preclinical Evidence That PD1 Blockade Cooperates with Cancer Vaccine TEGVAX to Elicit Regression of Established Tumors
Authors: Fu Juan , Malm Ian-James , Kadayakkara Deepak K. , Levitsky Hy , Pardoll Drew , Kim Young J.
Published: April 2023

PDF file - 50KB
Supplementary Figures 1 - 7 from HTLV-1 bZIP Factor Suppresses Apoptosis by Attenuating the Function of FoxO3a and Altering Its Localization
Authors: Tanaka-Nakanishi Azusa , Yasunaga Jun-ichirou , Takai Ken , Matsuoka Masao
Published: April 2023

PDF file - 373K, HBZ also inhibited Doxorubicin-induced cell death (S1); FoxO3a transcript in shRNA transfectant of Jurkat was quantified by real-time PCR (S2); Expression of the TP73 gene mRNA (S3); Comparison of the HBZ mRNA expression in Jurkat-HBZ, CEM-HBZ and ATL cell lines (S4); The results of GSE33615 affymetrix microarray data in Bim and FasL genes, which were normalized to GAPDH (S5); DNA methylation in the promoter region of the Bim gene (S6); Epigenetic status of the promoter1 of the Bim gene (S7).
Supplementary Figure 2 from Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
Authors: Lindner Andreas U. , Concannon Caoimhín G. , Boukes Gerhardt J. , Cannon Mary D. , Llambi Fabien , Ryan Deborah , Boland Karen , Kehoe Joan , McNamara Deborah A. , Murray Frank , Kay Elaine W. , Hector Suzanne , Green Douglas R. , Huber Heinrich J. , Prehn Jochen H.M.
Published: April 2023

PDF file - 53K, Temporal protein profiles for HCT-116 cells.
Supplementary Table 6 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: April 2023

XLSX file - 14K, Set of most significantly enriched biological functions as deterermined by IPA analysis based on the gene list in Supplementary Table 5.
Supplementary Figure Legend from Homing of Human B Cells to Lymphoid Organs and B-Cell Lymphoma Engraftment Are Controlled by Cell Adhesion Molecule JAM-C
Authors: Doñate Carmen , Ody Christiane , McKee Thomas , Ruault-Jungblut Sylvie , Fischer Nicolas , Ropraz Patricia , Imhof Beat A. , Matthes Thomas
Published: April 2023

PDF file - 80K
Supplementary Tables 1 - 9 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: April 2023

XLSX file - 2089K, Definition of 50 metrics of MT dynamics (1). Ranking of targets by number of changes in 23 selected metrics of MT dynamics (2). Reproducibility of effects on MT dynamics by 12 selected targets (3). Statistics of experiments in RPE and Meso-33 cells validating NF2 as a regulator of MT dynamics (4). Documentation of oligos used for gene depletion (5). Contains the raw values of of the 50 metrics for each target and movie aquired in primary or secondary screen (6). Comparison of Negctr and Allstar negatove controls for individual days (7). Documents for each of the 70 targets the variation of effects between different oligos of the same target (8). Identification of significant shifts in MT dynamics (9).
Supplementary Table 1 from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: April 2023

PDF file - 78KB, Tumor types in Tg-beta-cats mice.
Supplementary Figure 2 from β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Authors: Mokkapati Sharada , Niopek Katharina , Huang Le , Cunniff Kegan J. , Ruteshouser E. Cristy , deCaestecker Mark , Finegold Milton J. , Huff Vicki
Published: April 2023

PDF file - 105KB, FACS analysis of fetal cell suspensions for hepatic stem/progenitor markers.
Supplementary Table 1, Figure 1 - 6 from Soluble Carcinoembryonic Antigen Activates Endothelial Cells and Tumor Angiogenesis
Authors: Bramswig Kira H. , Poettler Marina , Unseld Matthias , Wrba Friedrich , Uhrin Pavel , Zimmermann Wolfgang , Zielinski Christoph C. , Prager Gerald W.
Published: April 2023

PDF file - 482K, Supplemental Table 1 displays patients' characteristics of paraffin-embedded tumor tissue sections analyzed in Figure 6D; Supplemental Fig.1 demonstrates tumor-vascularization of CEA-mimotop immunized mice; Supplemental Fig.2 displays Matrigel-invasion as well as CaKi2-xenotransplant in vivo assays; Supplemental Fig.3 gives a description of the purity of CEA used in in vitro assays; Supplemental Fig4 reflects CEA-induced integrin activation and it's independency of VEGF; Supplemental Fig.5 gives a summary of CEAR expression as well as a potential CEA effect in different cell types; Supplemental Fig.6 displays consequences of CEACAM1 downregulation on CEA-induced intracellular signal transduction; a detailed description of the materials and methods used is given in the appendix of the Supplemental Information.
Supplementary Tables 1 - 4 from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Authors: Rehman Sumaiyah K. , Li Shau-Hsuan , Wyszomierski Shannon L. , Wang Qingfei , Li Ping , Sahin Ozgur , Xiao Yi , Zhang Siyuan , Xiong Yan , Yang Jun , Wang Hai , Guo Hua , Zhang Jitao D. , Medina Daniel , Muller William J. , Yu Dihua
Published: April 2023

PDF file - 297K, Tumor incidence and latency in MMTV-HA-14-3-3zeta transgenic and wild type mice (S1); Mammary tumor histology and latency in female MMTV-HA-14-3-3zeta transgenic mice (S2); TMA Analysis (S3); Confusion matrix of SVM (S4).
Supplementary Methods from MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer
Authors: MacNeil Adam J. , Jiao Shun-Chang , McEachern Lori A. , Yang Yong Jun , Dennis Amanda , Yu Haiming , Xu Zhaolin , Marshall Jean S. , Lin Tong-Jun
Published: April 2023

PDF file - 116K
Supplementary Figure Legend from MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer
Authors: MacNeil Adam J. , Jiao Shun-Chang , McEachern Lori A. , Yang Yong Jun , Dennis Amanda , Yu Haiming , Xu Zhaolin , Marshall Jean S. , Lin Tong-Jun
Published: April 2023

PDF file - 86K
Movie 4 from ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics
Authors: Molina Angie , Velot Lauriane , Ghouinem Lydia , Abdelkarim Mohamed , Bouchet Benjamin Pierre , Luissint Anny-Claude , Bouhlel Imène , Morel Marina , Sapharikas Elène , Di Tommaso Anne , Honoré Stéphane , Braguer Diane , Gruel Nadège , Vincent-Salomon Anne , Delattre Olivier , Sigal-Zafrani Brigitte , André Fabrice , Terris Benoit , Akhmanova Anna , Di Benedetto Mélanie , Nahmias Clara , Rodrigues-Ferreira Sylvie
Published: April 2023

Movie 4 AVI file - 879K, Time-lapse videomicroscopy of wound healing assay using GFP-ATIP3-transiently transfected D3H2LN cells
Supplementary Table 1, Figures 1 - 8 from Cisplatin Resistance Associated with PARP Hyperactivation
Authors: Michels Judith , Vitale Ilio , Galluzzi Lorenzo , Adam Julien , Olaussen Ken André , Kepp Oliver , Senovilla Laura , Talhaoui Ibtissam , Guegan Justine , Enot David Pierre , Talbot Monique , Robin Angélique , Girard Philippe , Oréar Cédric , Lissa Delphine , Sukkurwala Abdul Qader , Garcia Pauline , Behnam-Motlagh Parviz , Kohno Kimitoshi , Wu Gen Sheng , Brenner Catherine , Dessen Philippe , Saparbaev Murat , Soria Jean-Charles , Castedo Maria , Kroemer Guido
Published: April 2023

PDF file - 490K, Supplementary Table S1. Systematic comparison of the effects of CDDP and PARP inhibitors on cancer cell lines used in this study. Supplementary Figure S1. Generation and characterization of CDDP-resistant human NSCLC cell clones. Supplementary Figure S2. Effects of CDDP and PARP inhibitors on the intracellular levels of poly(ADPribosyl) ated proteins in WT and CDDP-resistant NSCLC cells. Supplementary Figure S3. DNA damage as induced by PARP inhibitors is not a consequence of apoptotic caspase activation. Supplementary Figure S4. Markers of homologous recombination (HR) in CDDP-sensitive and CDDP-resistant A549 cells responding to PARP inhibitors. Supplementary Figure S5. DNA repair activity of A549 cell extracts towards dA�T- and THF�T-containing substrates. Supplementary Figure S6. DNA glycosylase activity of A549 cell extracts towards Hx�T- and U�G-containing substrates. Supplementary Figure S7. DNA repair activity of A549 cell extracts towards 5-OHC�T-and 8oxoG�C-containing substrates. Supplementary Figure S8. Expression levels and functional activity of XRCC1 and POL in CDDP-sensitive and CDDP-resistant cancer cells that overexpress PARP1 and contain high levels of poly(ADP-ribosyl)ated proteins.
Supplementary Video 3 from Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Authors: Martínez-Bosch Neus , Fernández-Barrena Maite G. , Moreno Mireia , Ortiz-Zapater Elena , Munné-Collado Jessica , Iglesias Mar , André Sabine , Gabius Hans-Joachim , Hwang Rosa F. , Poirier Françoise , Navas Carolina , Guerra Carmen , Fernández-Zapico Martin E. , Navarro Pilar
Published: April 2023

AVI file - 3727KB, Supplementary video 3 (Related to Figure 4E). Time lapse video microscopy in PANC-1 cells infected with a Gal1 shRNA (shGal1#2). Frames were collected every 15 min for 12h.
Supplementary Figure 4 from Parathyroid Hormone–Related Protein Drives a CD11b+Gr1+ Cell–Mediated Positive Feedback Loop to Support Prostate Cancer Growth
Authors: Park Serk In , Lee Changki , Sadler W. David , Koh Amy J. , Jones Jacqueline , Seo Jung Won , Soki Fabiana N. , Cho Sun Wook , Daignault Stephanie D. , McCauley Laurie K.
Published: April 2023

PDF file - 2044K, Supplemental Fig. 4 Anti-PTHrP monoclonal antibody suppress cellular proliferation.
Supplementary Video 1 from Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Authors: Martínez-Bosch Neus , Fernández-Barrena Maite G. , Moreno Mireia , Ortiz-Zapater Elena , Munné-Collado Jessica , Iglesias Mar , André Sabine , Gabius Hans-Joachim , Hwang Rosa F. , Poirier Françoise , Navas Carolina , Guerra Carmen , Fernández-Zapico Martin E. , Navarro Pilar
Published: April 2023

AVI file - 2551KB, Supplementary video 1 (Related to Figure 4E). Time lapse video microscopy in PANC-1 cells infected with a scrambled shRNA (shCtl). Frames were collected every 15 min for 12h.
Supplementary Methods, Tables 1 - 3; 5 - 6, Figures 1 - 10 from A DNA Methylation Prognostic Signature of Glioblastoma: Identification of NPTX2-PTEN-NF-κB Nexus
Authors: Shukla Sudhanshu , Pia Patric Irene Rosita , Thinagararjan Sivaarumugam , Srinivasan Sujaya , Mondal Baisakhi , Hegde Alangar S. , Chandramouli Bangalore A. , Santosh Vani , Arivazhagan Arimappamagan , Somasundaram Kumaravel
Published: April 2023

PDF file - 5025K, Supplementary Figure SF1: ROC analysis and risk stratification in three groups ; Supplementary Figure SF2: Risk score distribution of TCGA and our patients' cohort and and heatmap of 9 genes in TCGA cohort ; Supplementary Figure SF3: Kaplan meier analysis and Risk score distribution of Bent et al data set ; Supplementary Figure SF4: NFkb network and EMSA of NFkB protein ; Supplementary Figure SF5: Heat map of differentially expressed genes in low and high risk of REMBRANDT and Phillips et al datasets ; Supplementary Figure SF6: Kaplan meier analysis and landscape analysis of REMBRANDT and Phillips et al datasets ; Supplementary Figure SF7: NPTX2 expression level and methylation level correlation ; Supplementary Figure SF8: NPTX2 inhibits NFkB activity ; Supplementary Figure SF9: NPTX2 inhibits NFkB nuclear translocation ; Supplementary Figure SF10: NPTX2 inhibits NFkB activity by activating p53 dependent PTEN pathway.Table ST1: Kaplan Meier overall survival analysisin our patient set and the TCGA data set. ; Table ST2: Univariate and multivariate Cox regression analysis of methylation risk score with 9-gene predictor and 10-miRNA prognostic signature ; Table ST3: Multivariate Cox regression analysis of methylation risk score and other Prognostic markers using Bent et al. data set ; Table ST4: Differentially expressed genes between low and high risk ; Table ST5: Significantly enriched networks obtained from Metacore network analysis ; ST6: List of NFkB target genes overexpressed only in high-risk but not in Low risk compared to normal.
Supplementary Figures 1 - 10 from Real-time In Vivo Molecular Detection of Primary Tumors and Metastases with Ratiometric Activatable Cell-Penetrating Peptides
Authors: Savariar Elamprakash N. , Felsen Csilla N. , Nashi Nadia , Jiang Tao , Ellies Lesley G. , Steinbach Paul , Tsien Roger Y. , Nguyen Quyen T.
Published: April 2023

PDF file - 835K, Supplementary Fig 1. Structures of RACPP1,2,3 and uncleavable control. Supplementary Fig 2. Structures of synthesized RACPPs with varying acceptor fluorophores. Supplementary Fig 3. Characterization of RACPP2. Supplementary Fig 4. Ratiometric RACPP images show superior contrast compared to Cy5 fluorescence alone. Supplementary Fig 5. RACPPs show specificity for MMP2,9 cleavage in transgenic animal models. Supplementary Fig 6. RACPPs show tumor specific cleavage and uptake. Supplementary Fig 7. Non-ratiometric ACPP has poor contrast in liver metastases. Supplementary Fig 8. Ratiometric analyses using RACPPs show sensitive detection of metastatic lymph nodes. Supplementary Fig 9. LCMS characterization of RACPPs. Supplementary Fig 10. Synthetic schemes for RACPPs.
Supplementary Table 1 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia
Authors: Bunda Severa , Kang Michelle W. , Sybingco Stephanie S. , Weng Julie , Favre Helene , Shin Danielle H. , Irwin Meredith S. , Loh Mignon L. , Ohh Michael
Published: April 2023

PDF file - 310K, JMML patient-derived primary cell information
Supplementary Figure Legend from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia
Authors: Bunda Severa , Kang Michelle W. , Sybingco Stephanie S. , Weng Julie , Favre Helene , Shin Danielle H. , Irwin Meredith S. , Loh Mignon L. , Ohh Michael
Published: April 2023

PDF file - 52K
Supplementary Methods, Figure Legends from Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells
Authors: Horiguchi Michiko , Koyanagi Satoru , Hamdan Ahmed M. , Kakimoto Keisuke , Matsunaga Naoya , Yamashita Chikamasa , Ohdo Shigehiro
Published: April 2023

PDF file - 138K
Supplementary Figure 4 from Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells
Authors: Horiguchi Michiko , Koyanagi Satoru , Hamdan Ahmed M. , Kakimoto Keisuke , Matsunaga Naoya , Yamashita Chikamasa , Ohdo Shigehiro
Published: April 2023

PDF file - 67K, Excess expression of p53 in oncogene-introduced Atf4-/- cells overrides the binding capacity of SV40LT.
Supplementary Figure 2 from Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells
Authors: Horiguchi Michiko , Koyanagi Satoru , Hamdan Ahmed M. , Kakimoto Keisuke , Matsunaga Naoya , Yamashita Chikamasa , Ohdo Shigehiro
Published: April 2023

PDF file - 378K, Temporal expression profiles of p53 mRNA in oncogenic transformed wild-type and Atf4-/- cells.
Supplementary Figure 1 from Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells
Authors: Horiguchi Michiko , Koyanagi Satoru , Hamdan Ahmed M. , Kakimoto Keisuke , Matsunaga Naoya , Yamashita Chikamasa , Ohdo Shigehiro
Published: April 2023

PDF file - 1958K, UV.BAL-5.4G tumor cells express wild-type p53 protein.
Supplementary Table 2 from Targeting the Deregulated Spliceosome Core Machinery in Cancer Cells Triggers mTOR Blockade and Autophagy
Authors: Quidville Virginie , Alsafadi Samar , Goubar Aïcha , Commo Frédéric , Scott Véronique , Pioche-Durieu Catherine , Girault Isabelle , Baconnais Sonia , Le Cam Eric , Lazar Vladimir , Delaloge Suzette , Saghatchian Mahasti , Pautier Patricia , Morice Philippe , Dessen Philippe , Vagner Stéphan , André Fabrice
Published: April 2023

PDF file - 58K, Supplemental Table S2: The primers and probe sequences used for the qPCR for mTOR and house-keeping gene
Supplementary Table 1 from Targeting the Deregulated Spliceosome Core Machinery in Cancer Cells Triggers mTOR Blockade and Autophagy
Authors: Quidville Virginie , Alsafadi Samar , Goubar Aïcha , Commo Frédéric , Scott Véronique , Pioche-Durieu Catherine , Girault Isabelle , Baconnais Sonia , Le Cam Eric , Lazar Vladimir , Delaloge Suzette , Saghatchian Mahasti , Pautier Patricia , Morice Philippe , Dessen Philippe , Vagner Stéphan , André Fabrice
Published: April 2023

PDF file - 43K, Supplemental Table S1: SNRPD1 and SNRPE specific siRNA sequences used for transfection
Supplementary Table 1 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 75K, Gene set enrichment analysis using embryonic stem cell (ESC) gene sets.
Supplementary Figure 2 from Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
Authors: Dijkgraaf Eveline M. , Heusinkveld Moniek , Tummers Bart , Vogelpoel Lisa T.C. , Goedemans Renske , Jha Veena , Nortier Johan W.R. , Welters Marij J.P. , Kroep Judith R. , van der Burg Sjoerd H.
Published: April 2023

PDF file - 913K, Cell lines were untreated or cultured with cisplatin or carboplatin. RNA was isolated and mRNA levels of PTGS1 and IL-6 were analyzed by quantative PCR. Representative experiment of two experiments. ND: not detectable. Cervical cancer cell lines; CSCC1, CASKI, HELA, CC8 and CSCC7. Ovarian cancer cell lines; SKOV3, OVCAR3, A2780, COV413B and CAOV3.
Supplementary Figure 1 from Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
Authors: Dijkgraaf Eveline M. , Heusinkveld Moniek , Tummers Bart , Vogelpoel Lisa T.C. , Goedemans Renske , Jha Veena , Nortier Johan W.R. , Welters Marij J.P. , Kroep Judith R. , van der Burg Sjoerd H.
Published: April 2023

PDF file - 1243K, An MTT assay was performed to measure survival of cancer cells upon treatment with chemotherapy. Mean of 3 experiments performed in triplicate. Survival of cervical cancer cell lines HELA, CC8. CSCC7, CASKI and CSCC1 upon treatment with A) Cisplatin and B) Carboplatin. Survival of ovarian cancer cell lines COV413B, CAOV3, SKOV3, OVCAR3 and A2780 upon treatment with C) Cisplatin and D) Carboplatin.
Supplementary Figure 8 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 125K, Tumors generated by PC3.Luc xenografts as described in Figure 5 were dissociated in single cell suspensions and cells (105 cells/injection) were injected subcutaneously in the right flank of nude mice (n = 5).
Supplementary Methods from Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C
Authors: Stout Gerdine J. , Blasco Maria A.
Published: April 2023

PDF file - 92K, Includes Immunohistochemistry data, COFISH and MTS analysis