bluuebunny/crossref_metadata_2025 huggingface dataset:
Influencia del uso de escritorios virtuales y la mejora del trabajo remoto de los asesores de negocio en la entidad financiera MiBanco
Authors:   , Peñaranda Huerta Jesús Eduardo
Published: January 2023

El objetivo de esta investigación es determinar cómo el uso de escritorios virtuales influye en la mejora del trabajo remoto de los asesores de negocio. Se realizó una encuesta a 269 asesores de negocio para determinar el impacto del uso de escritorios virtuales como herramienta tecnológica para el trabajo remoto. Según los resultados, hay una clara influencia en el uso de los escritorios virtuales para lograr la eficiencia y cumplimiento de sus objetivos en la modalidad de trabajo remoto. Se concluye que la tecnología ha sido fundamental para evitar una caída drástica en la productividad de las organizaciones causada por la pandemia, que obligó a la mayoría de las empresas a implementar la modalidad de trabajo remoto en un tiempo muy corto, lo que supuso enfrentar uno de los retos más complejos bajo circunstancias nunca experimentadas.
Habitat and nutrients, but not artificial lighting at night, drive fish assemblage composition in urban streams
Authors: Bohenek Jason , Sulliván S. Mažeika Patricio , Gray Suzanne M.
Published: January 2023

Artificial light at night (ALAN) is pervasive in urban environments, yet its potential effects on biotic communities of urban streams are not fully understood. We investigated the effects of ALAN on fish assemblages in 20 lit-unlit paired stream reaches across 10 sites in Columbus, Ohio, USA across two years. Our results show that light trespass into urban streams is approximately doubled during leaf-off in winter months (1.97 lux ± 0.28) compared to leaf-on in summer months (1.00 lux ± 0.19), highlighting the important interceptive effect of canopy coverage in headwater systems. There were no differences in fish assemblages (i.e., abundance, relative abundance, biomass, diversity, guild composition) between lit and unlit reaches (> 100 m apart). Species richness and α-diversity (Hill numbers) scaled positively with mean stream depth. Nutrient concentrations were negatively related to mean fish mass and fish assemblage diversity. Species richness scaled negatively with total phosphorus and α-diversity scaled negatively with orthophosphate. Our results imply that the relatively low-levels of ALAN observed in canopied streams may exert only subtle effects on small stream fish assemblages, which are difficult to detect amongst the multiple, confounded stressors impacting these relatively species-poor, urban systems. Experimental approaches or large-scale manipulative studies may be necessary to isolate the effects of ALAN on streams and fish in urban contexts.
The mRNA m6A reader YTHDF2 suppresses the proliferation and migration of pterygium fibroblasts
Authors: Li Yunping , Peng Yangyang , Yang Xue , Qi Xi , Tong Boding , Bai Xiaojing , Li Yuan , Wang Lujue
Published: January 2023

BACKGROUND: Pterygium is a common, benign ocular surface disease. Its characteristics, such as hyper-proliferation, anti-apoptotic behavior, and high recurrence rate, contribute to the tumourigenic-like features. Emerging evidence has shown that N6-methyladenosine (m6A) modification plays a vital role in pterygium progression. YTHDF2, an m6A reader, is recognized as promoting targeted mRNA decay. However, the effect of YTHDF2 on pterygium fibroblasts is unknown and remains to be elucidated.
METHODS: 42 pterygium tissues and 42 conjunctiva tissues were obtained from pterygium patients who were recruited from the 2nd Xiangya Hospital. The level of m6A modification was detected using an m6A RNA Methylation Quantification Kit. Quantitative real-time PCR (qRT-PCR) compared the differential expression among binding proteins, methyltransferases, and demethylases. The expression and location of YTHDF2 were identified by immunofluorescence. Plasmid construction, Cell transfection, Western blotting, Cell Counting Kit-8 (CCK-8), and Scratch Wound Healing Assay were used to evaluate the effect of YTHDF2 on proliferation and migration of cultured human pterygium fibroblasts (HPFs). RESULTS: Our research demonstrated that YTHDF2 expression was decreased in HPFs, and overexpression of YTHDF2 could inhibit the proliferation and migration of HPFs. Global m6A expression levels were related to the expression of multiple m6A-related proteins.
CONCLUSIONS: Our study indicated that YTHDF2 might act as a suppressor to suppress the proliferation and migration of fibroblasts in pterygium. This finding provides additional insight into understanding the role of m6A modification in pterygium.
“Nine-step method”mastoscopic scar-hidden surgery on gynecomastia：a single-institution， large sample experiences
Authors: Luo Chengyu , Zhang Shuqi , Wei Changsheng , Guo Yang , Zhang Yajing
Published: January 2023

Background: To summarize the experiences on the mastopscopic subcutaneous mastectomyfor gynecomastia by "nine-step method"based on the "5S" goal ，and standardize this operation.
Patients and methods：Between January 1st 2002 and October 31st 2021，a total of 2035 breasts of 1082 male patients with gynecomastia, of which 129 patients with one side, were underwent mastopscopic subcutaneous mastectomy.
Results：All patients were successfully completed the operation, and none of them was transferred to open operation. The operation time for unilateral breast was 12-28 min, and the average time was 17.7±6.2 min. The amount of bleeding during unilateral operation was very small, about 5-10ml. The total drainage volume was 5ml~50ml after the operation, and the drainage tube was removed in 3~5 days. The epidermal necrosis occurred in 0.3% nipple. 0.2% chest wall had a little ecchymosis in the upper- inner region of the breast. All patients had the normal feeling of nipples and areola, the smoothing and symmetrical chest wall, and the natural contour. There was no recurrence during the follow-up period.
Conclusions：The mastopscopic subcutaneous mastectomy for gynecomastia by "nine-step method" based on the "5S" goal has a short operation time, few surgical complications and good esthetics. It achieving the "5S" goals on the complete removal of glandular tissue（sweeping）, small and scar-hidden incision are small（scarless）,good symmetry of bilateral chest wall (symmetry), normal chest shape (shape), and smoothing chest wall（smoothing）.
Computational Correlation analysis of In-doped Aluminium Antimonide Alloy for Optoelectronic Applications: A First Principle Study
Authors: Nabi Shafqat , Anwar Abdul Waheed , Ahmad Muhammad , Haq Najam Ul , Waqas Rana , Tayyab Muhammad , Moin Muhammad , Ali Anwar , Afzal Muhammad , Nabi Kashif
Published: January 2023

The first Principle calculations are made to study the structural electronic and optical properties for indium doped aluminum antimonide. The most appropriate method of density functional theory (DFT) naming Full Potential Linearized Augmented Plane Wave (FP-LAPW) is used. The structural properties like Lattice constant (a), pressure derivative, bulk modulus (B) examined by Local density approximation (LDA) along with generalized gradient approximation (GGA). Generalized gradient approximation along with TB-mBJ is used to determine electronic parameters like band structure along and density of states. According to the computed results the binary compound AlSb is optically inactive and exhibits an indirect (Γ -L) band gap. By increasing the concentration of indium with different percentages, the indirect band gape shifted to direct (Γ – Γ) band gap which shows material is optically active. The optical properties of material including dielectric (Real and imaginary part) constant, reflectivity, refractive index, energy loss, absorption coefficient, and optical conductivity have changed significantly. Electronic and optical properties are modified by (TB-mBJ) approach. The results obtained are examined with experimental data and utilized as a starting point to propose that the material is the superlative choice for optoelectronic devices/applications.
Designing for trust: user-friendly refugee wellness center planning process and concept, a health design case study
Authors: Solomon Ellen , Joa Brandon , Coffman Shandon , Faircloth Billie , Altshuler Marc , Ku Bon
Published: January 2023

Background
Refugee and immigrant populations have diverse cultural factors that affect their access to health care and must be considered when building a new clinical space. Health design thinking can help a clinical team evaluate and consolidate these factors while maintaining close contact with architects, patients’ community leaders, and hospital or institutional leadership. A diverse group of clinicians, medical students, community leaders and architects planned a clinic devoted to refugee and immigrant health, a first-of-its-kind for South Philadelphia.
Methods
The planning process and concept design of this wellness center is presented as a design case study to demonstrate how principles and methods of human-centered design were used to create a community clinic. Design thinking begins with empathizing with the end users’ experiences before moving to ideation and prototyping of a solution. These steps were accomplished through focus groups, a design workshop, and iterations of the center’s plan.
Results
Focus groups were thematically analyzed and generated two themes of access and resources and seven culturally specific subthemes that informed the design workshop. A final floor plan of the wellness center was selected, incorporating priorities of all stakeholders and addressing issues of disease prevention, social determinants of health, and lifestyle-related illness that were relevant to the patient population.
Conclusions
Design thinking methods are useful for health care organizations that must adapt to the needs of diverse stakeholders and especially underserved or displaced populations. While much has been written on the theory and stages of design thinking, this study is novel in describing this methodology from the beginning to the end of the process of planning a clinical space with input from the patient population. This study thus serves as a proof of concept of the application of design thinking in planning clinical spaces.
The photocoagulation-assisted aesthetic treatment of phlebectasias of the lips by using a Nd:YAG laser with a low energy level
Authors: Armogida Niccolò Giuseppe , Calabria Elena , Canfora Federica , Valletta Alessandra , Rengo Carlo , Spagnuolo Gianrico
Published: January 2023

Background: Venous lakes (VL) are benign malformations often localized in the lips, thereby impacting on the self-confidence of the patients. In the present study, the use of an Nd:YAG laser, according to a defined protocol with an absolute low energy level, is proposed for the treatment of VL of the lips.
Methods: 50 patients with VL of the lips were treated with the Nd:YAG in one laser session, without local anaesthesia. The area reduction, according to the Vlachakis criteria, was evaluated 7 and 30 days after the laser application. Additionally, the oral discomfort, rated according to the Numeric Rating Scale (NRS) during and 24 hours after the procedure, was recorded.
Results: All the patients with VL achieved a complete clinical healing within 30 days after the laser application. In particular, those patients with VL with a diameter ≤ 6 mm (62.1%) achieved a complete resolution after 7 days (p-value: <0.001). Such patients reported no or little discomfort (NRS 0 to 3) during the laser session and no discomfort after 24 hours (p-value < 0.001). No major complications were reported and no recurrence was observed at a 2-year follow up.
Conclusions: These findings suggest that Nd:YAG laser treatment could be an effective and well-tolerated approach in the aesthetic treatment of VL of the lips.
Characterization of Chimeric Antigen Receptor Modified T Cells Expressing scFv-IL-13Rα2 after Radiolabeling with 89Zirconium Oxine for PET Imaging
Authors: Leland Pamela , Kumar Dhiraj , Nimaggada Sridhar , Bauer Steven R , Puri Raj K , Joshi Bharat H
Published: January 2023

Background
Chimeric antigen receptor (CAR) T cell therapy is an exciting cell-based cancer immunotherapy. Unfortunately, CAR-T cell therapy is associated with serious toxicities such as cytokine release syndrome (CRS) and neurotoxicity. The mechanism of these serious adverse events (SAEs) and how homing, distribution and retention of CAR-T cells contribute to toxicities is not fully understood.
Methods
To determine if radiolabelling of CAR-T cells could support positron emission tomography (PET)-based biodistribution studies, we labeled IL-13Rα2 targeting scFv-IL-13Rα2-CAR-T cells (CAR-T cells) with 89Zirconium-oxine (89Zr-oxine), and characterized and compared their product attributes with non-labeled CAR-T cells. The 89Zr-oxine labeling conditions were optimized for incubation time, temperature, and use of serum for labeling. In addition, product attributes of radiolabeled CAR-T cells were studied to assess their overall quality including cell viability, proliferation, phenotype markers of T-cell activation and exhaustion, cytolytic activity and release of interferon-γ upon co-culture with IL-13Rα2 expressing glioma cells.
Results
We observed that radiolabeling of CAR-T cells with 89Zr-oxine is quick, efficient, and radioactivity is retained in the cells for at least 8 days with minimal loss. Also, viability of radiolabeled CAR-T cells was similar to that of unlabeled cells as determined by TUNEL assay and caspase 3/7 enzyme activity assay. Moreover, there were no significant changes in T cell activation (CD24, CD44, CD69 and IFN-γ) or T cell exhaustion(PD-1, LAG-3 and TIM3) markers expression between radiolabeled and unlabeled CAR-T cells. In chemotaxis assays, migratory capability of radiolabeled CAR-T cells to IL-13Rα2Fc was similar to that of non-labeled cells.
Conclusions
Importantly, radiolabeling has minimal impact on biological product attributes including potency of CAR-T cells towards IL-13Rα2 positive tumor cells but not IL-13Rα2 negative cells as measured by cytolytic activity and release of IFN-γ. Thus, IL-13Rα2 targeting CAR-T cells radiolabeled with 89Zr-oxine retain critical product attributes and suggest 89Zr-oxine radiolabeling of CAR-T cells may facilitate biodistribution and tissue trafficking studies in vivo using PET.
Corrosion performance of Wire and Arc
Additive Manufacturing 316L stainless steel
in as-deposited and post heat treatment
conditions
Authors: penot Corentin , Wharton Julian , Addison Adrian , Wang Yikun , Lu Qing
Published: January 2023

Corrosion performance of a multi-layered ER316LSi wall deposited using wire and arc additive manufacturing was studied in the as-deposited condition and after stress relief heat treatment at 900 ℃, in 3.5 wt.% NaCl solution. It was found that the heat treatment is not suitable for WAAM ER316LSi components due to the complete transformation of the delta ferrite into sigma decreasing the corrosion performance. The delta ferrite to sigma transformation during heat treatment was facilitated by the cyclic reheating of the part during deposition. The electrochemical response of as-deposited WAAM differed from a wrought alloy with similar composition and linked to microstructural differences: as-deposited WAAM had a higher pitting potential due to the absence of sulfide inclusions and increased metastable activity due to the presence of the secondary delta ferrite causing elemental segregation.
A bioprocess for rapid compost production from rice straw using C/N ratio improvers and indigenous microorganisms at the lab and pilot scales
Authors: Sharafi Reza , Jouzani Gholamreza Salehi , Karimi Ebrahim , Ghanavati Hossein , Kowsari Mojegan
Published: January 2023

Management of agricultural waste like rice straw is essential in reducing environmental pollution and also creating added value. For this purpose, microorganisms with high hydrolytic activities were isolated from a simulated composting process. The effects of different materials, including rice straw, chicken manure, urea, olive pomace, and two groups of microbial boosters were assayed at lab-scale and pilot-scale for 60 days. The lab-scale results showed that two treatments containing chicken manure and microbial cocktails (E and F) improved the composting process significantly better than others. They had maximum temperature (59°C), C/N reduction rate (76.7%), and macro/microelements contents. Treatment E showed maximum wheat growth indexes, including dry (1.1 g) and wet (4.7 g) weight of aerial parts, plant height (47 cm), leaf area index (18.9 cm2), and leaf specific area index (45 cm2/g) compared to the control. The pilot-scale results showed that E treatment could reduce C/N (73.48%) better than F (58.32%) and control (13.03%) and it also caused most of the temperature changes up to 69°C. Finally, considering the highest germination index (96%) and lack of phytotoxicity, and also the greatest impact on wheat growth indexes, treatment E was selected for industrial production of compost.
Development and validation of an ultrasound diagnostic nomogram to predict benign or malignant lymph nodes in HIV-infected patients
Authors: Huang Chen , Shi Xia , Ma Xin , Liu Jianjian , Huang Jingjing , Deng Li , Cao Ye , Zhao Mingkun
Published: January 2023

Objective
This study aimed to establish an effective ultrasound diagnostic nomogram for benign or malignant lymph nodes in HIV-infected patients.
Methods
The nomogram is based on a retrospective study of 131 HIV-infected patients who underwent ultrasound assess at the Shanghai Public Health Clinical Center from December 2017 to July 2022. The nomogram's predictive accuracy and discriminative ability were determined by concordance index (C-index) and calibration curve analysis. A nomogram combining the lymph node US characteristics were generated based on the multivariate logistic regression results.
Results
Predictors contained in the ultrasound diagnostic nomogram included age (OR 1.044 95%CI: 1.014-1.074 P= 0.004), number of enlarged lymph node regions (OR 5.445 95%CI: 1.139-26.029 P= 0.034), and CDFI grades (OR 9.614 95%CI: 1.889-48.930 P= 0.006). The model displayed good discrimination with a C (ROC) of 0.775 and good calibration.
Conclusions
The proposed nomogram may result in more-accurate diagnostic predictions for benign or malignant lymph nodes in patients with HIV infection.
Climate-Induced Shifts in Irrigation Water Demand and Supply during Sensitive Crop Growth Phases in South Asia
Authors: Ahmad QURAT UL AIN , Moors Eddy , Biemans Hester , Shaheen Nuzba , Masih Ilyas , HASHMI Muhammad Zia ur Rahman
Published: January 2023

This study investigated climate-induced shifts in irrigation water demand and supply of the major staple and water-intensive crops (wheat and rice) in the Indus, Ganges and Brahmaputra (IGB) river basins of South Asia. It explores irrigation water usage during climate-sensitive crop growth phases (i.e., vegetative and reproductive which required ~ 60% of the total crop water demand), which is supposed to be crucial for long-term integrated crop water management. A hydrology vegetation model LPJmL is forced with an ensemble of eight downscaled (5 arc-min) GCM’s using a mix of two emission scenarios i.e., RCP4.5-SSP1 and RCP8.5-SSP3. To investigate phase-specific shifts in crop water use during the period 1981-2100, trend analysis is performed. It shows a significant (p<0.001) increase in irrigation water demand during the vegetative phase of wheat (6 mm) and reproductive phase of rice (26 mm) and a decrease during the reproductive phase of wheat (13 mm) and vegetative phase of rice (11 mm) in selected study sites. The large decrease in projected irrigation demand for wheat can be explained by a shortening of growing season length as a result of rising temperatures and increased precipitation. Whereas, an increase in irrigation demand for rice is a combined effect of higher temperatures and less precipitation during the reproductive phase in the region. At the same time, irrigation supply by surface water and groundwater is likely to change in future due to warmer and drier growing periods, causing a significant increase in groundwater irrigation, mainly for rice. Our major research findings show the importance of crop water assessments during the sensitive crop growth phases of wheat and rice which vary in space and time. Including crop phase-specific, climate impact assessments of regional and global projection will help improve the region's existing crop-water management strategies and adaptation practices.
Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions
Authors: Kusová Alžbeta , Steinbachová Lenka , Přerovská Tereza , Drábková Lenka Záveská , Paleček Jan , Khan Ahamed , Rigóová Gabriela , Gadiou Zuzana , Jourdain Claire , Stricker Tino , Schubert Daniel , Honys David , Schrumpfová Petra Procházková
Published: January 2023

Telomere repeat binding proteins (TRBs) belong to a family of proteins possessing a Myb-like domain which binds to telomeric repeats. Three members of this family (TRB1, TRB2, TRB3) from Arabidopsis thaliana have already been described as associated with terminal telomeric repeats (telomeres) or short interstitial telomeric repeats in gene promoters (telo-boxes). They are also known to interact with several protein complexes: telomerase, Polycomb repressive complex 2 (PRC2) E(z) subunits and the PEAT complex (PWOs-EPCRs-ARIDs-TRBs). Here we characterize two novel members of the TRB family (TRB4 and TRB5). Our wide phylogenetic analyses have shown that TRB proteins evolved in the plant kingdom after the transition to a terrestrial habitat in Streptophyta, and consequently TRBs diversified in seed plants. TRB4-5 share common TRB motifs while differing in several others and seem to have an earlier phylogenetic origin than TRB1-3. Their common Myb-like domains bind long arrays of telomeric repeats in vitro, and we have determined the minimal recognition motif of all TRBs as one telo-box. Our data indicate that despite the distinct localization patterns of TRB1-3 and TRB4-5 in situ, all members of TRB family mutually interact and also bind to telomerase/PRC2/PEAT complexes. Additionally, we have detected novel interactions between TRB4-5 and EMF2 and VRN2, which are Su(z)12 subunits of PRC2.
A Direct Construction of Optimal 2D-ZCACS with Flexible Array Size and Large Set Size
Authors: GHOSH GOBINDA , Majhi Sudhan , Paul Subhabrata
Published: January 2023

In this paper, we propose a direct construction of optimal two-dimensional Z-complementary array code sets (2D-ZCACS) using multivariable functions (MVFs). In contrast to earlier works, the proposed construction allows for a flexible array size and a large set size. Additionally, the proposed design can be transformed into a one-dimensional Z-complementary code set (1D-ZCCS). Many of the 1D-ZCCS described in the literature appeared to be special cases of this proposed construction. At last, we compare our work with the current state of the art and then draw our conclusions.
Higher resistance of a microcystin (MC)-producing cyanobacterium, Microcystis to the submerged macrophyte Myriophyllum spicatum
Authors: Gao Yunni , Yang Hui , Li Longfei , Gao Xiaofei , Li Mei , Dong Jing , Zhang Man , Zhang Jingxiao , Li Xuejun , Lu Zhiying , Burford Michele A
Published: January 2023

Microcystin (MC) -producing and non-MC-producing Microcystisstrains typically coexist in Microcystis-dominated blooms. However, the interaction between submerged plants and Microcystis at strain level is not clear. This study aimed to assess the effects of a submerged macrophyte Myriophyllum spicatum on one MC-producing versus one non- MC-producing strains of the cyanobacterium Microcystis using plant-Microcystis co-culture experiments. The impacts of Microcystis on M. spicatum were also examined. It showed that the MC-producing Microcystis strain had a higher resistance to negative impacts by the cocultured submerged plant M. spicatum than the non-MC-producing strain. By contrast, the plant M. spicatum was impacted more by the MC-producing Microcystis than the non-MC-producer. The associated bacterioplankton community was affected more by the MC-producing Microcystis than the cocultured M. spicatum. The MC cell quotas were significantly higher in the coculture treatment (the PM+ treatment, p < 0.05), indicating that the production and release of MCs might be a key factor responsible for the reduced impact of M. spicatum. The higher concentrations of dissolved organic and reducing inorganic compounds might eventually exacerbate the recovering capacity of co-existing submerged plants. Overall, this study indicated that the capacity to produce MCs, as well as the density of Microcystis should be taken into account when attempting to re-establish submerged vegetation to undertake remediation works.
Operation mode selection of offshore wind power PPP project: A case in China
Authors: Zhao Hui , Yu Guikun , Gao Jing
Published: January 2023

As the world economy recovers from the coronavirus pandemic, we used coal in large quantities to fuel economic growth. The issue of excessive carbon emissions is once again causing concern. In this context, how to cope with the risks faced by offshore wind power projects and choose the most favorable PPP project operation mode has become a hot research issue in the dual-carbon background. This study identifies risk factors for offshore wind power PPP projects and constructs an analytical hierarchical process consistent with a triangular ambiguity number for empowerment. The VIKOR hesitancy fuzzy multi-attribute method based on prospect theory is used for the terminal decision and comparative analysis. We have constructed a model of operational mode selection for PPP projects for offshore wind power generation and verified its practicality and scientificity through empirical calculations. This paper discusses and points out the rational progress model of future offshore wind power project PPP model and based on this maximizes the venture of offshore wind power PPP project. The above studies are expected to provide a useful reference for the reasonable burden of offshore wind PPP projects and the development of current energy sources in a low-carbon context.
Levonorgestrel Intrauterine System (LNG-IUS)- First Line Treatment of AUB
Authors: Kaur Prabhjot , GARG RAMA , Kaur Gurdip
Published: January 2023

Background: Abnormal uterine bleeding (AUB) is a significant cause of hysterectomy, hence a major health problem. This study was done to evaluate the effectiveness of LNG-IUS in different indications of AUB.
Materials and Methods: This was a prospective and observational study conducted at Government Medical College- A Tertiary Care Institute in Northern India over a period of 18 months from January 2019 to June 2020. A total of 40 women in the reproductive age group with AUB having no contraindication for the device, underwent LNG IUS insertion after the consent and followed up at 3,6,9, and 12 months.
Results: At 3 months -24 (60%) women had a decrease in mean blood loss (MBL) and16 (40 %) continued with heavy menstrual bleeding(HMB). But most of the women complained of intermenstrual spotting, which needed time-to-time counseling. There was no expulsion and need for removal. At 12 months - 33 women continued with LNG-IUS: 25 women had a decrease in , 7 women achieved amenorrhea and 1 woman persisted with HMB. A total of 32/40 (80%) women were relieved from AUB: [25/40(62.5%) women decrease in MBL, and amenorrhea in 7/40(17.5%]. Only one/40(2.5%) women persisted with HMB, 4/40 (10%)women expelled, 2/40(5%) women got removed from the device as one wanted to conceive, and another had dyspareunia. Only one woman140(2.5%) underwent hysterectomy. The majority 32/40(80.000%) of the patients were satisfied with the treatment. The increase in Hb was less than anticipated. No major side effect was noted.
Conclusion:LNG-IUS is an excellent treatment modality for patients of AUB, with good patient satisfaction. It is highly effective in controlling blood loss, well tolerated, with no need for admission, and a better alternative for hysterectomy in the reproductive age group.
Pediatric schistosomiasis in hard-to-reach areas and populations: a scoping review
Authors: Isaiah Phyllis Munyiva , Palmeirim Marta Sólveig , Steinmann Peter
Published: January 2023

Background
Schistosomiasis affects over 200 million people worldwide. Despite children and the poor being key risk groups, limited research and control activities target pre-school aged children (PSAC) and hard-to-reach populations. As endemic countries shift the goals of their schistosomiasis programs from morbidity control to disease elimination, there is a need for inclusive planning to cover all affected age groups from all geographical areas and populations to achieve sustainable impact and health equity.
Methods
We conducted searches in Medline, Web of Science, Embase (Ovid), and LILACS per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - Extension for Scoping Reviews (PRISMA-ScR) guidelines. Quality assessment of identified articles was done using the Joanna Briggs Institute Prevalence Critical Appraisal Tool. Relevant study data were extracted from the articles and entered into Microsoft Excel 2016 for descriptive analysis.
Results
From 17,179 screened articles, we identified 13 eligible studies on PSAC living in hard-to-reach areas and populations. All identified studies were from Sub-Saharan Africa. The mean sample size of the retained studies was 572, with a balanced sex distribution among the young children sampled in each study. Ten studies investigated Schistosoma mansoni, one investigated S. haematobium, while two covered both S. mansoni and S. haematobium in the target population. The prevalence of S. mansoni among PSAC in the included studies was estimated at 12.9% in Ghana, 80.3–90.5% in Kenya, 35.0% in Madagascar, 9.6–78.0% in Senegal, 11.2–35.4% in Sierra Leone, 44.4–54.9% in Tanzania and 39.3–74.9% in Uganda. Out of the three studies that investigated S. haematobium, the presence of the infection was reported in only one study carried out in Nigeria. Schistosome infections reported in nearly all studies included in this review were of light intensity. Only one study conducted in Nigeria documented visible hematuria in 17.7% of the PSAC studied.
Conclusion
The findings document the high prevalence of schistosomiasis among PSAC in hard-to-reach populations and underscore the need to consider this population subgroup when designing the expansion of preventive chemotherapy and schistosomiasis control activities.
Comparative study of ultrasonographic and ultra-wide-field fundus for measurements of the diameter of choroidal and retinal tumors
Authors: Yang Qiong , Wang Qian , Yang Jingyan , Wei Wen Bin
Published: January 2023

Background
Measurement of the largest basal dimension (LBD) of intraocular tumors is important as a prognostic parameter. In order to evaluate the potential value of true color wide-field fundus photography in the measurement of tumors, we compared the measurements of the LBD of choroidal and retinal tumors by color ultra-wide-field fundus camera to clinical estimation based on indirect ophthalmoscopy and standardized ophthalmic ultrasound.
Methods
The LBD of 148 choroidal and retinal tumors of 148 patients seen at the Tongren Hospital were measured by ultra-wide-field fundus photography and compared with those measured by B-scan ultrasound and clinical estimation based on indirect ophthalmoscopy.
Results
Paired t-tests reveal that measurements from wide-field fundus photographic images are not statistically different from clinical estimation and ultrasound measurements. The results also showed that, although not statistically significant, when the tumor boundary was clear, the height ༜3 mm or the tumor was pigmented, the measurement value of wide-field fundus photography was greater than that measured by ultrasound. However, when the vitreous opacity, subretinal fluid or retinal detachment obscures the tumor, or the tumor is too large, or the tumor is located in the peripheral retina and close to the ciliary body, it is difficult to obtain accurate measurement by wide-field fundus photography.
Conclusions
The LBD measurement by wide-field fundus photography correlated well with ultrasonography and clinical estimation and could be used as a reliable tool for LBD measurement of choroidal and retinal tumors.
The Influence of Emotional Intelligence on Academic Stress. A Study with University of Medical Sciences Students
Authors: Khorasani Elham Charoghchian , Ardameh Mohammad , Tehrani Hadi , Ghavami Vahid , Gholian-aval Mahdi
Published: January 2023

Background
The purpose of this study was to investigate the effect of an intervention based on an emotional intelligence component on the coping skills of academic stress in medical students.
Methods
This research has been done in two descriptive and quasi-experimental sections in the academic student. In order to determine the effect of emotional intelligence components on stress levels, this descriptive study was performed on 200 students. Then, a quasi-experimental study was then conducted to determine the effect of an emotional intelligence component-based educational intervention on academic stress coping skills. Data were collected through personal information questionnaire, Bradbury and Graves emotional intelligence questionnaire and Gadzella’s academic stress questionnaire.
Results
Emotional intelligence components predicted 27.1% of the variance of academic stress among students. In parallel with the effect of education, the experimental group showed a statistically significant difference in the mean of each of the components of emotional intelligence and the overall score of academic stress (p > 0.05).
Conclusions
Educational intervention based on emotional intelligence components can significantly help reduce students' academic stress.
Evolution of the Main Hospital Activity Indicators in Sikasso Hospital, Mali, 2015-2021.
Authors: Sidi Haidara Dadé Ben
Published: January 2023

Introduction: The right information system makes it possible to describe and evaluate hospital activity and the performance of a hospital establishment. The objective of this work was to describe the trends in Sikasso's hospital activity over the past seven years.
Methods: This was a descriptive study using existing data at Sikasso Hospital. Ports of entry staff handled all admissions between January 1, 2015 and December 31, 2021.
Results: Analysis of the data showed that Sikasso Hospital has 14 wards, eight of which are inpatient and have a capacity of 163 beds.
The total number of hospitalizations decreased from 6747 (2015) to 5899 (2021). This evolution varied from one department to another with an increase over the years in hospitalizations from consultation at the expense of those from emergencies, especially at the level of pediatrics and gynecology.
The average length of stay increased from three days in 2015 to four days in 2021, while the overall bed occupancy rate varied from year to year and from service to service. It averaged 44.55% with a minimum of 40% in 2020 and a maximum of 49.96% in 2016. During this period, the overall mortality rate was 9.62%, and 9.99% in 2015 to 9.35% in 2021.
Conclusion : The existing information system, with its shortcomings, allowed us to describe the main indicators of activity in our hospital
An AI based Voice Controlled Humanoid Robot
Authors: Naeem Bisma , Saeed-Ul-Hassan  , Yousuf Nadeem
Published: January 2023

Humanoid robots may be utilized in daily life and are more efficient at performing tasks that humans would find unpleasant. Robots are getting more proficient and are capable of performing many tasks that humans can. In a world designed for people, creating robots that behave like humans is a significant problem for robotics. In this study, we introduce a Voice Controlled Humanoid Robot, a mobile robot that can be moved by the operator by issuing precise voice instructions. The Google Voice API is used to handle the voice command when it is picked up by an Android phone's microphone. The vocal signals are then translated into text by the app, which creates a variable against the text and sends it to the Arduino Node MCU in the form of a command. The Arduino Node MCU then examines the instruction and performs the necessary operations. The VCHR app and VCHR system are linked together using the Bluetooth module. The android app also has a camera for live video streaming, and the robot can utilize its SONAR sensors to identify any obstacles in its path and sound an alert as a result. VCHR can carry out around 20 distinct tasks in total. When given voice input through the supplied external mic, the VCHR system is also capable of speech-emotion recognition in addition to these characteristics. The IoT cloud service provider ThingSpeak receives the temperature sensor data from the VCHR system in order to analyze and interpret the sensor data at various time intervals. The performance obtained for movement, speech emotion recognition, and sensor data processing is demonstrated by experimental findings.
The spatial spillover effect of ICT development level on regional CO2 emissions--Evidence from Chinese cities
Authors: Su Jinqi , Wang Wenbo , Tang Shiyao
Published: January 2023

Information and Communication Technology plays an essential role in affecting CO2 emissions and promoting green and sustainable development. This paper estimates the CO2 emissions of 259 cities in China from 2011 to 2017 and uses the spatial Durbin model to empirically analyze the spatial spillover effect of the level of ICT development affecting regional CO2 emissions and to further analyze its direct, indirect, and total effects. The study finds that: (1) There is a spatial correlation between regional CO2 emissions and ICT development level, and the CO2 emissions of Chinese cities show high-high or low-low clustering characteristics; (2) The level of ICT development can significantly increase CO2 emissions in the region and significantly suppress CO2 emissions in neighboring regions, and after a series of robustness tests, the findings of the study still hold; (3) The mechanism of action shows that ICT can influence regional CO2 emissions through the three elements included in it: infrastructure, application level, and service level; (4) The effect of ICT on regional CO2 emissions varies by city resource allocation and level of science and education.
Exploring Genetic Alterations in Hodgkin Lymphoma using Comparative Genomic Hybridization on DNA Microarrays
Authors: Almosawy Baneen , Alzeyadi Mohammad
Published: January 2023

The genetic alterations can contribute to the development and progression of the disease. In the case of c HL, a type of cancer that affects the immune system, understanding the genetic changes that occur may inform the development of more targeted and effective treatments. In this study, we used comparative genomic hybridization CGH on DNA microarrays to perform a whole-genome analysis of 30 individuals, 15 patients with HL and 15 healthy controls. Aberrations were divided into three groups based on size: large aberrations, regional aberrations, and microstructural aberrations Our results showed that there were more duplications of genetic material (gains) than deletions (losses), and that specific genetic additions and deletions were present in multiple tumors. Aberrations were divided into three groups based on size: large, regional, and microstructural. Large aberrations included trisomy of whole chromosomes and gains or losses of chromosome arms. Regional aberrations were greater than 5 Mb in size and were found on multiple chromosomes. Microstructural aberrations were smaller than 5 Mb and had high amplitudes. Amplification of specific loci, such as 5q31.1 and 8q24.3, were found in multiple tumors, and loss of a single region, such as 8q22.1, was found in multiple tumors as well. it appears that genetic alterations of chromosome 8, specifically the 8q21-8q22 and 8q24.2 regions, are common in individuals with Hodgkin lymphoma. In particular, the MYC and MALT1 genes, as well as the RAD54B protein, may play a role in the development of Hodgkin lymphoma. and could potentially be targeted for therapeutic purposes. Overall, the results of this study provide insight into the genetic alterations present in Hodgkin lymphoma and may inform future research and treatment approaches. Further research is needed to fully understand the functional consequences of these genetic changes and to explore their potential as therapeutic targets. Exploring Genetic Alterations in Hodgkin Lymphoma using Comparative Genomic Hybridization on DNA Microarrays
Drag Reduction of Complex Mixtures in Turbulent Pipe Flows
Authors: Watanabe Keizo , Ogata Satoshi
Published: January 2023

The drag reduction of high molecular polymer solutions can be divided into two types: Type A and B. Type A corresponds to the solutions of synthetic polymers such as polyethylene oxide or polyacrylic amide. In contrast, Type B corresponds to the solutions of biopolymers such as xanthan gum, guar gum, and polysaccharide. Experiments were performed to measure the friction factor and heat transfer coefficient for the aqueous suspensions of graphene oxide shin-plate particles. The results show that the complex fluids exhibit a Type B drag reduction phenomenon in the turbulent flow range. The onset point of the drag reduction was found to be 𝑅𝑒√𝑓 ≅ 260 for Cw=0.1 wt%. This point increased compared to the experimental results for Cw = 0.5 wt% graphene oxide solutions that have been reported on drag reduction. In general, aqueous suspensions of fine particles are characterized by an increase in the friction factor and the heat transfer coefficient as compared to water. However, the aqueous suspension of the graphene shin-plate particles produces the drag reduction of the friction factor and increases the heat transfer coefficient. Therefore, suspensions become a useful carrier for the cooling pipeline system. Considering the predicted velocity profiles of the aqueous suspensions of graphene oxide shin-plate particles and the dried malted rice culture solutions classified as biopolymer, it was pointed out that the thickness of the viscous sublayer increases, and the width of the buffer zone narrows in the turbulent pipe flow on the mechanism of Type B drag reduction.
Extent of Nutritional failure among under-five children from an urban slum in South India: A cross-sectional assessment using Composite index of Anthropometric failure
Authors: Mohandas Anu , Priya Hamsa , Varma Pavani , Pattnaik Snigdha
Published: January 2023

Introduction

NFHS-5 Telangana statistics reports underweight, stunting, and wasting among under 5 children to be 31.8%, 33.1%, and 21.7% respectively.Nutritional assessment is done by several methods. Composite Index of Anthropometric Failure(CIAF) is an aggregate indicator that excludes children with anthropometric failure and includes children who are wasted, stunted, or underweight, and their combinations. Only a few published research regarding the prevalence of under nutrition have utilized CIAF and explored the association between food intake with anthropometric failures in urban slums of Telangana.

Objectives

To determine the prevalence of anthropometric nutritional failures and to find the determinants among under-five children in an urban slum area of Hyderabad

Methodology

A cross sectional community based study was conducted among 309 under 5 children residing in the urban-slum area of Hyderabad. Sampling of anganwadis was done by probability proportionate to size and children were randomly selected within anganwadis. Using questionnaire and standard operating procedures, socio-demographic profile, health details and nutritional assessment was done. Statistical analysis was done using SPSS version 26.

Results

The prevalence of under nutrition as per CIAF is noted to be 39.6%. The prevalence of stunting, underweight and wasting were found to be 20.7%, 26.8% and 12%, respectively. The illiteracy of father[AOR:2.94(CI: 1.31–6.62);p value = 0.009],low birth weight[AOR:2.024(CI: 1.253–3.26);p value = 0.004], not exclusively breastfed[AOR:4.291(CI: 1.55-11.904);p value = 0.005] and deficient calorie intake[AOR:2.079(CI:1.103–3.906);p value = 0.023]were found to be the significant predictors of Anthropometric failure.

Conclusion

Under nutrition is an important public health problem with 40% prevalence in urban slum of Telangana. CIAF provides a single, aggregated assessment of under nutrition in the community. Enhancing the literacy level of fathers, reduction in low birth weight through better nutrition of mothers during pregnancy, better IYCF practices and providing children with a calorie adequate diet will aid in enhancing children's nutritional status.
Tropical tree quality and sawmill yield in the amazon rainforest
Authors: Casagrande Michelly
Published: January 2023

The low sawn timber yield of tropical species is caused by quality of the logs, among other factors. The objective was to evaluate the quality of logs and the sawn wood yield for export of the tropical species. The log quality parameters analyzed were conicity, flattening, curving, buttresses, cracks, heartwood percentage and net volume. The yield of sawn timber for export differed between species and ranged There was variation in the quality of the logs and the yield of sawn timber for export due to the distinctive characteristics of the species evaluated.
Taraxasterol suppresses the proliferation and tumor growth of prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway
Authors: Yang Jinqiu , Xin Chulin , Yin Guangfen , Li Juan
Published: January 2023

Prostate cancer (PCa)is prevalent among older men and difficult to survive after metastasis. It is urgent to find new drugs and treatments. Several studies show that taraxasterol (TAX) has important anti-inflammatory, anti-oxidative and anti-tumor effects. However, the function and mechanisms of TAX in PCa remain unclear. Here, we found that TAX could significantly suppress the viability and growth of PCa cells and down-regulate the expression of c-Myc and cyclin D1 in vitro. Mechanistically, PI3K/AKT signaling pathway was weakened and the expression of FGFR2 was reduced after TAX treatment in PCa cells. Moreover, TAX evidently inhibited the tumor growth in nude mice and the expression of c-Myc, cyclin D1, p-AKT and FGFR2 were down-regulated in xenograft tumor. These results indicate that TAX suppresses the proliferation of PCa cells via inhibiting the activation of PI3K/AKT signaling pathway and the expression of FGFR2, which means TAX may be a novel anti-tumor agent for PCa treatment.
Extensive systemic thrombo embolism including intra-cardiac thrombosis mimicking an atrial myxoma in a patient with beta thalassaemia major
Authors: Welhenge Chiranthi , Ranasinghe Rumesh , Rajapakse Sanjeewa , Premawardhena Anuja
Published: January 2023

We report the case of a 20-year-old female splenectomised thalassaemia major patient with severe iron overload, who presented with life threatening sepsis associated with a liver abscess. Her clinical course was complicated with an intra cardiac thrombus. 2D echocardiogram and Contrast Enhanced Computed Tomography (CECT) chest revealed a large oscillating mass in right atrium extending from the left hepatic vein through the inferior vena cava. After a prolonged Intensive Care Unit (ICU) stay supported with antibiotics and anticoagulation she had a good clinical recovery with evidence of resolution of the intra cardiac thrombus.