bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomechanical study on the stress distribution of the knee joint after residual rotation deformity of tibial fracture
Authors: Li Ming , Zhu Yanbin , Wei Ning , Chang Wenli , Jin Zeyue , Yan Ying , Du Hao , Chen Wei
Published: February 2020

Objectives To investigate the effect of residual rotation deformity on the stress distribution of the knee joint after surgery to treat middle and upper tibial fractures. Methods Fourteen adult cadaver specimens that were preserved with formalin were included, and the tibias were randomly positioned at 0 degree, 5 degrees, 10 degrees, and 15 degrees from the line of force of the lower limb. These positions modeled deformities of 5 degrees, 10 degrees, and 15 degrees from the line of force. Low-pressure pressure-sensitive film technology measured the stress distribution of the knee joint under different degrees of rotation deformity. Results Under a vertical load of 400 N, the difference between the medial and lateral stress of the knee joint was significantly different between the different tibia deformities (P<0.05), and the medial stress of the knee joint was higher than the lateral stress. The current study showed that there were statistically significant differences in the medial stress on the knee joint at all angles (including the neutral position of 0 degrees) (F=89.753, P<0.001) . There was a statistically significant difference in the lateral stresses of the knee joint between different rotation deformities (including the neutral position of 0 degrees) (F=102.998, P<0.001). Conclusions Residual rotation deformity after fracture of middle and upper tibia can lead to poor alignment of lower limb force and change of articular contact characteristics of knee joint, especially external rotation of tibia.Therefore, orthopedic surgeons should correct the malalignment of lower limbs to the greatest extent and reduce the rotation deformity as far as possible.
Development and validation of a predictive model for predicting acute kidney injury in patients with acute pancreatitis
Authors: Yang Dongliang , Kang Jian , Wen Chao , Zhang Xiujie , Song Jing , Wang Hui , Jiang Li , Gao Dongna , Zhang Huanhuan , Xue Lin , Li Yuling
Published: February 2020

Background: Acute kidney injury is a serious complication of acute pancreatitis and significantly increases the risk of mortality. Early identification of acute kidney injury is important for medical interventions and care options. The aim of this study is to develop a predictive model that could rapidly identify high-risk population of acute kidney injury in patients with acute pancreatitis. Methods: Totally 808 patients with acute pancreatitis admitted to our center from January 2015 to May 2019 were included in the study and were divided into the training (n =566) and validation (n = 242) cohorts randomly, in a 2:1 ratio. The least absolute shrinkage and selection operator (LASSO) regression was used for data dimension reduction and feature selection; then, multivariable logistic regression analysis was used to develop the prediction model. The performance of this nomogram was evaluated with calibration and validated in the validation set. Decision curve analysis was applied to evaluate the clinical usefulness of this model. Results: Five potential predictors (BMI, RANSON score, serum uric acid, triglycerides and lactate) from 53 high‑dimensional clinical variables were incorporated to develop the prediction model of acute kidney injury. The nomogram demonstrated valuable prediction performance with AUROC of 0.994 and 0.996 in the training and validation cohorts, respectively. Individual risk probability was visually scored. The nomogram achieved fine calibration and good clinical usefulness. Conclusions: The proposed nomogram can help to identify high-risk population of acute kidney injury in patients with acute pancreatitis and facilitate timely individualized clinical decision‑making. Keywords: acute kidney injury; acute pancreatitis; risk factor; nomogram
Spatial patterns and associated factors’ of Early Marriage among Reproductive age women in Ethiopia: a Secondary Analysis of Ethiopian Demographic and Health Survey 2016
Authors: Tadesse Zemenu Tessema
Published: February 2020

Background

Besides, the presence of national law, the country has to set up its own mid-term and long term goals to bring about a significant reduction in child marriages in Ethiopia. To achieve this, determining the spatial pattern of early marriage and factors associated is important for government, other concerned bodies, program implementers and policy developers to end up early childhood marriage. Thus, the aim of this study was to assess the spatial patterns and associated factors of Early marriage among reproductive-age women in Ethiopia.

Methods

This study analyzed retrospectively a cross-sectional data on a weighted sample of 11,646 women aged 15-49 years after requesting from Ethiopian Demographic and Health Survey 2016 via the link www.measuredhs.com . ArcGIS version 10.7 software was used to visualize spatial distribution for Early marriage. The Bernoulli model was applied using Kilduff SaTScan version 9.6 software to identify significant purely spatial clusters for Early marriage in Ethiopia multiple logistic regression analysis was used to identify factors associated with early marriage. Finally, variables with a p-value<0.05 were considered as statistically significant.

Results

In this analysis, about 62.8% (95%CI: 61.9, 63.74%) of the study participants were married before they reached 18 years. The overall median age at first marriage was 17.1 with IQR 5 years. The high clustering of early marriage was located in Amhara, Afar, and Gambella Regions. In spatial Scan statistics 87 clusters (RR = 1.28, P-value < 0.001) significant primary clusters were identified. The associated factors of early marriage were lesser among women’s attending primary (AOR=0.60; 95%CI: 0.51, 0.71), secondary (AOR=0.19; 95%CI: 0.13, 0.26) and tertiary education (AOR=0.11; 95%CI: 0.07, 0.18). Similarly, women found in Addis Ababa were at a lesser risk of early marriage compared to other regions of the country.

Conclusion

Marriage below age 18 was high in Ethiopia. High-risk area of early marriage was located in Amhara, Afar, and Gambella and special attention should be given for identified risk areas. Therefore, providing educational opportunities to young girls was important in addition to inhibiting the marriage of girls under 18 years.
Systematic analysis of 4-gene prognostic signature in patients with diffuse gliomas based on gene expression profiles
Authors: Huang Chunhai , Xiong Zujian , Li Xuejun
Published: February 2020

Background: Diffuse gliomas are a group of diseases that contain different degrees of malignancy and complex heterogeneity. Previous studies proposed biomarkers for certain grades of gliomas, but few of them have conducted a systematic analysis of different grades to search for molecular markers.Methods: WGCNA was used to find significant genes associated with malignant progression of diffuse glioma in TCGA glioma sequencing expression data and the GEO expression profile-merge meta dataset. Lasso regression was used for potential model building and the best model was selected by CPE, IDI and C_index. Risk score model was used to evaluate the gene signature prognostic power. Multi-omics data, including CNV, methylation, clinical traits and mutation, were used for model evaluation.Results: We find out 67 genes significantly associated with malignant progression of diffuse glioma by WGCNA. Next, we establish a new 4 gene molecular marker (KDELR2, EMP3, TIMP1, and TAGLN2). Multivariate cox analysis identified the risk score of the 4 genes as an independent predictor of prognosis in patients with diffuse gliomas, and its predictive power was independent of the histopathological grades of glioma. Further, we had confirmed in five independent test datasets and the risk score remained good predictive power. The combination of the prognosis model with specific molecular characteristics possessed better predictive power than risk score solely and we divided the low-risk group into three subtypes: LowRisk_IDH1wt, LowRisk_IDH1mut/ATRXmut, and LowRisk_IDH1mut/ATRXwt by combining IDH1 mutation with ATRX mutation, which possessed obvious survival difference. In further analysis, we found that the 4 gene prognosis model possessed multi-omics features.Conclusion: we established a malignant-related 4-gene molecular marker by glioma expression profile data from multiple microarrays and sequencing data. The four markers had good predictive power on the overall survival of glioma patients and were associated with gliomas’ clinical and genetic backgrounds, including clinical features, gene mutation, methylation, CNV, signal pathways.
Combined Effects of Lifestyle Risk Factors on Fatty Liver Index
Authors: Nivukoski Ulla , Niemelä Markus , Bloigu Aini , Bloigu Risto , Aalto Mauri , Laatikainen Tiina , Niemelä Onni
Published: February 2020

Background: Factors of lifestyle may have a major impact on liver-related morbidity and mortality.We examined independent and joint effects of lifestyle risk factors on fatty liver index (FLI), a biomarker of hepatic steatosis, in a population-based cross-sectional national health survey. Methods: The study included 12,368 participants (5,784 men, 6,584 women) aged 25–74 years. Quantitative estimates of alcohol use, smoking, adiposity and physical activity were used to establish a total score of risk factors, with higher scores indicating an unhealthier lifestyle. FLI was calculated based on an algorithm including body mass index, waist circumference, serum gamma-glutamyltransferase and triglycerides.Results: The occurrence of FLI ≥ 60% indicating fatty liver increased from 2.4% in men with zero risk factors to 81.9% in those with a total risk score of 7–8 (p < 0.0005 for linear trend) and in women from 0% to 73.5% (p < 0.0005). The most striking individual impacts on the likelihood for FLI above 60% were observed for physical inactivity (p < 0.0005 for both genders) and alcohol consumption (p < 0.0005 for men). Interestingly, coffee consumption was also found to increase with increasing risk factor scores (p < 0.0005 for linear trend in both genders).Conclusions: The data indicates that unfavorable combinations of lifestyle risk factors lead to a high likelihood of hepatic steatosis. Use of FLI as a diagnostic tool may benefit the assessment of interventions aimed at maintaining a healthy lifestyle and prevention of liver-related morbidity.
β-glucosidase genes differentially expressed during composting
Authors: Zhang Xinyue , Chen Xiehui , Li Shanshan , Su Erlie , Liu Jiawen , Gao Liyuan , Ma Bo , Li Hongtao
Published: February 2020

Background: Cellulose degradation by cellulase is brought about by complex communities of interacting microorganism, which significantly to the cycling of carbon on a global scale. β-Glucosidase is the rate-limiting enzyme of degradation of cellulose. Thus, analysis of expression of genes involved in cellulose degradation and regulation of β-glucosidase gene expression in composting is beneficial to a better understanding of cellulose degradation mechanism. According to our previous researches, we present the hypothesis that “microbial functional communities differentially regulate the expression of glucose-tolerant β-glucosidase and glucose sensitive β-glucosidase (up or down regulation) to adapt to the changes in cellulose degradation.” Results: Here, the functional microbial community structure and function change in association with cellulose degradation during the process of natural and inoculated composts was investigated by metatranscriptome and DNA clone library. Compared with inoculated compost, cellulose degradation was obviously inhibited during natural composting. Especially, the cooling phase of natural compost exhibited carbon catabolite repression (CCR) effect due to high concentration of glucose and cellobiose. The expression of genes encoding endoglucanase and exoglucanase were significantly down-regulation, while the CCR has no effect on β-glucosidase genes expression levels. But functional microbial community composition changed significantly, the composition of glucose-tolerant β-glucosidase increased. Conclusions: These results indicated that microbial functional communities differentially regulate the expression of glucose tolerant β-glucosidase (up regulation) and non-glucose tolerant β-glucosidase (down regulation) under CCR. This work provides a frame work to predict how functional microbial communities will respond to cellulose degradation conditions changes.
Gastric tumorigenesis induced either by Helicobacter pylori infection or chronic alcohol consumption through IL-10 inhibition
Authors: Aziz Faisal , Chakarobaty Abhijit , Liu Kandong , Yoshitomi Hisae , Li Xiang , Monts Josh , Xu Gang , Li Yonghan , Bai Ruihua , Bode Ann M. , Dong Zigang
Published: February 2020

Background Alcohol is class 1 carcinogen and results in 3.3 million deaths every year. H. pylori is also an important factor for gastric carcinogen. Alcohol consumption is emerging as an important contributor to gastric cancer, but there is no direct or experimental evidence of alcohol and H. pylori infection produce gastric cancer in human and animal model alone. Here, we provide insight into the molecular mechanisms driving gastric carcinogenesis. Results Alcohol consumption, together with H. pylori infection, causes gastric cancer; interleukin-10 (IL-10) downregulation and mitochondrial metabolic dysfunction in CD8+ cells are also involved. IL-10 knockout accelerates tumor development in mice with either H. pylori infection or alcohol induced gastric cancer or both. IL-10 downregulation and CD-8+ cell dysfunction stimulates IL-1β secretion. Specifically, we show IL-10 inhibits glucose uptake and glycolysis and promotes oxidative phosphorylation with lactate inhibition. Consequently, In the absence of IL-10 signaling, CD8+ cells accumulate damaged mitochondria in a mouse model of gastric cancer induced with the combination of alcohol plus H. pylori infection, and this results in mitochondrial dysfunction and production of IL-1 β. IL-1β promotes H. pylori infection and reduces NKX6.3 gene expression, resulting in increased cancer cell survival and proliferation. Conclusions Overall, the molecular mechanisms of gastric carcinogenesis include IL-10 inhibition resulting in lowered host immunity via mitochondrial dysfunction of CD8+ lymphocytes; gastric inflammation due to H. pylori infection, alcohol intake, and IL-1β production; and disruption of gastric-specific tumor suppressor NKX6.3 expression, which increases cancer cell survival and proliferation.
Genome-wide analysis of physic nut MADS-box gene family and functional characterization of the JcMADS05 gene in transgenic rice
Authors: Tang Yuehui , Wang Jian , Bao Xinxin , Wu Qian , Yang Tongwen , Li Han , Wang Wenxia , Zhang Yizhen , Bai Nannan , Guan Yaxin , Dai Jiaxi , Xie Yanjie , Li Shen , Huo Rui , Cheng Wei
Published: February 2020

Background: Physic nut (Jatropha curcas), a non-edible oilseed plant, is among the most promising alternative energy sources because of its high seed oil content, rapid growth and extensive adaptability. Proteins encoded by MADS-box genes are important transcription factors involved in the regulation of plant growth, seed development and responses to abiotic stress. However, there has been no in-depth research on the MADS-box genes and their roles in physic nut. Results: In the present study, 63 MADS-box genes (JcMADSs) were identified in the physic nut genome, and classed into five groups (MIKC, Mα, Mβ, Mγ, Mδ) based on phylogenetic comparison with Arabidopsis homologs. Expression profile analysis based on RNA-seq suggested that many JcMADS genes were expressed most strongly in seeds, and seven of them responded in leaves to at least one abiotic stressor (drought and/or salinity) at one or more time points. Transient expression analysis and a transactivation assay indicated that JcMADS05 is a nucleus-localized transcriptional activator. Plants overexpressing JcMADS05 did not show altered plant growth, but the overexpressing plants did exhibit reductions in grain size, grain length, grain width, 1000-seed weight and yield per plant. Further data on the reduced grain size in JcMADS05-overexpressing plants supported the putative role of JcMADS genes in seed development. Conclusions: This study will be useful in understanding the involvement of MADS-box genes in growth and development in addition to their functions in abiotic stress resistance, and will ultimately form the basis for functional characterization and the exploitation of candidate genes for the genetic engineering of physic nut.
The Three-Gap Model of Health Worker Performance
Authors: Ibnat Fabliha , Leonard Kenneth , Bawo Luke , Mohammed-Roberts Rianna
Published: February 2020

Background: Improving process quality remains a signiﬁcant opportunity to improve outcomes in many low resource settings, however a continued focus on improving knowledge through increased training has proven ineﬀective. In this context, we introduce a methodology for diagnosing the causes of low quality care, including not only low knowledge, but also infrastructure and material as well as motivation.Methods: The Three-Gap Model uses four measures of performance — target performance, actual performance, the capacity to perform and the knowledge to perform — to deﬁne three gaps for each health worker: the gap between target performance and what they have the knowledge to do (the know gap); the gap between their knowledge and their capacity to perform (the know-can gap) and the gap between their capacity and what they actually do (the can-do gap).Results: Using data on pediatric care from hospitals in Liberia, we illustrate how the model can be used to investigate the potential for improvements in the quality of care from several possible policy interventionsConclusions: The analysis of the relationships between these gaps across health workers in a health system help to paint a better picture of the determinants of performance and can assist policymakers in choosing relevant policies to improve health worker performance.
Challenge for Diagnostic Assessment of Deep Learning Algorithm for Metastases Classification in Sentinel Lymph Nodes on Frozen Tissue Section Digital Slides in Women with Breast Cancer
Authors: Kim Young-Gon , Song In Hye , Lee Hyunna , Yang Dong Hyun , Kim Namkug , Shin Dongho , Yoo Yeonsoo , Lee Kyowoon , Kim Dahye , Jung Hwejin , Cho Hyunbin , Lee Hyungyu , Kim Taeu , Choi Jong Hyun , Seo Changwon , Han Seong il , Lee Young Je , Lee Young Seo , Yoo Hyung-Ryun , Lee Yongju , Park Jeong Hwan , Gong Gyungyub , Oh Sohee
Published: February 2020

Assessing the status of metastasis in sentinel lymph nodes (SLNs) by pathologists is an essential task for the accurate staging of breast cancer. However, histopathological evaluation of sentinel lymph nodes by a pathologist is not easy and is a tedious and time-consuming task. The purpose of this study is to review a challenge competition (HeLP 2018) to develop automated solutions for the classification of metastases in hematoxylin and eosin–stained frozen tissue sections of SLNs in breast cancer patients. A total of 297 digital slides were obtained from frozen SLN sections, which include post–neoadjuvant cases (n = 144, 48.5%) in Asan Medical Center, South Korea. The slides were divided into training, development, and validation sets. All of the imaging datasets have been manually segmented by expert pathologists. A total of 10 participants were allowed to use the Kakao challenge platform for six weeks with two P40 GPUs. The algorithms were assessed in terms of the AUC (area under receiver operating characteristic curve). The top three teams showed 0.986, 0.985, and 0.945 AUCs for the development set and 0.805, 0.776, and 0.765 AUCs for the validation set. Micrometastatic tumors, neoadjuvant systemic therapy, invasive lobular carcinoma, and histologic grade 3 were associated with lower diagnostic accuracy. In a challenge competition, accurate deep learning algorithms have been developed, which can be helpful in making frozen diagnosis of intraoperative sentinel lymph node biopsy. Whether this approach has clinical utility will require evaluation in a clinical setting.
Prevalence and Risk Factors for Anxiety and Depression in Chinese Unruptured Intracranial Aneurysms Patients Treated by Endovascular Intervention
Authors: Zhai Xiao-Dong , Yu Jia-Xing , Ma Yong-Jie , Li Gui-Lin , He Chuan , Hu Peng , Xiang Si-Shi , Wang Jun , Zhang Hong-Qi
Published: February 2020

Background: Studies on anxiety and depression after treatment via endovascular intervention for unruptured intracranial aneurysm (UIA) patients are rare and controversial. We aimed to explore the prevalence of anxiety and depression among Chinese UIA patients treated by endovascular intervention and to identify which factors contribute to the development of these symptoms.Methods: We performed a cross-sectional study of anxiety and depression in patients who underwent endovascular treatment for UIAs using the Hospital Anxiety and Depression Scale (HADS). The demographic, clinical and radiological data for all patients were retrospectively collected from the aneurysm database and medical records. Moreover, we utilized a large sample data and logistic regression analysis to investigate the risk factors for the anxiety and depression for these patients. Results: Two hundred patients returned a completed questionnaire in this study. Of the 200 patients, 34 (17.0%) suffered from anxiety, and 31 (15.5%) suffered from depression after being discharged for 30.67±8.6 months. The multivariate analysis results indicated that treatment cost exceeding the annual household income was statistically significantly associated with anxiety (OR= 2.42, p= 0.03). Patients with shorter sleep time was statistically significantly associated with anxiety (OR= 1.51, p= 0.02) and depression (OR= 1.62, p= 0.007).Conclusion: The prevalence of anxiety and depression in the UIA patients treated by endovascular intervention was 17.0% and 15.5% respectively. Treatment cost exceeding the annual household income was statistically significantly associated with anxiety. Patients with shorter sleep time was statistically significantly associated with anxiety and depression. Our findings provide valuable evidence for the clinical and psychological management of these patients.
PLACE AND ROLE OF SUPPLY CHAINS IN THE AGRICULTURAL INDUSTRY OF UKRAINE
Authors: Syhyda L. , Sigida N.
Published: February 2020

The purpose of this article is to analyze the agricultural sector of Ukraine and to determine the importance of supply chains for industry efficiency increasing.
As a result of the study, the main indicators of the agricultural sector functioning in Ukraine were analyzed. The obtained results make it possible to characterize the burning situation, as well as to develop appropriate proposals for its improvement in the future (taking into account marketing and logistical components). Almost 18% of the able-bodied population of Ukraine were employed in the agriculture sector in 2016. At the same time, the largest share of agricultural enterprises is located in three regions of Ukraine – Odesa, Dnipropetrovsk, and Mykolaiv.
It is determined that in 2007-2016 there is a steady increase in agricultural production. It is enough to meet the internal needs of the population and export needs. It is proved that the basis of Ukrainian exports is primary agricultural products (wheat, corn, soybeans). Despite the gradual increase in food exports (by 16% from 2010 to 2016), the share of value-added goods in exports remains low. It indicates Ukraine's specialization as a supplier of raw materials on the world market.
Besides, it is found that the share of imports for agriculture needs remains high. Mainly mineral fertilizers, agricultural machines, petroleum products are imported. The reason is that the need for these things is not fully met by domestic producers. Accordingly, it is determined that all the above requires the formation of internal supply chains of agricultural enterprises (they allow to establish relations between structural units) as well as external supply chains (they allow to establish partnerships with counterparties in Ukraine and abroad).
It is established that in the supply chains’ formation it is necessary to take into account the main problems of the agricultural sector, in particular, the involvement of new producers of agricultural products in export activities; increasing the share of value-added products in exports; coverage of new markets in foreign countries. The solution to these problems is crucial for the country too.
Keywords:
agriculture, import, export, supply chain, industry.
On the synonymy of Trophotylenchulus asoensis and T. okamotoi with T. arenarius, and intra-generic structure of Paratylenchus (Nematoda: Tylenchulidae)
Authors: Mirbabaei Hossein , Eskandari Ali , Ghaderi Reza , Karegar Akbar
Published: February 2020

Two populations of the genus Trophotylenchulus and 10 species of the genus Paratylenchus from Iran were characterized based on morphometric, morphological and molecular characters. Our observations on the two populations of Trophotylenchulus from Iran revealed that T. asoensis and T. okamotoi have been distinguished from T. arenarius, on the basis of the features which cannot be longer considered as stable diagnostic characters. One of the populations shows a mixed combination of the characters of T. arenarius and T. asoensis; it has morphometrics more similar to T. arenarius but shows affinities with T. asoensis in the tail terminus shape of females and second-stage juveniles (J2) and in having a reduced stylet in males. The other population fit well with T. okamotoi; it has females with generally bluntly rounded tails typical for T. okamotoi, but sometimes with finely rounded tail termini, like those of T. arenarius or T. asoensis. The sequences of D2–D3 expansion segments of 28 S rRNA gene for the two populations are identical with each other, but only 4 bp (0.67%) difference with T. arenarius sequence deposited in the GenBank. Considering no stable difference allow separating species, synonymy of T. asoensis and T. okamotoi with T. arenarius, which has already been proposed, is supported and confirmed here. All studied Paratylenchus species with stylets longer than 40 µm, except P. straeleni, formed a basal cluster to Cacopaurus pestis and species of Paratylenchus bearing stylets shorter than 40 µm; thus, validity of Gracilacus cannot be rejected using our data sets. However, the synonymy of Paratylenchoides was supported by the positioning of P. sheri within representatives of Paratylenchus in the inferred phylogenetic tree.
Reproduction and life history traits of a resistance breaking Globodera pallida population
Authors: Mwangi James M. , Niere Björn , Finckh Maria R. , Krüssel Stefan , Kiewnick Sebastian
Published: February 2020

The main and most efficient measure to control potato cyst nematode (PCN) is the use of resistant cultivars. German and Dutch National Plant Protection Organizations (NPPOs) recently reported the emergence of Globodera pallida populations virulent on potato cultivars carrying resistance against pathotype 2/3. The development and virulence of the virulent population Oberlangen from Germany in comparison to the reference population G. pallida Pa3 Chavornay were investigated on resistant and susceptible cultivars in glasshouse experiments. Various life history traits associated with change in virulence were also assessed. Hatching of second-stage juveniles (J2s) was similar for both populations but incubation of cysts in potato root diffusate resulted in higher hatching rates compared to 3 mM Zinc Chloride and tap water. Both populations showed high penetration rates in the roots of the resistant and susceptible cultivars. However, only the population Oberlangen was able to complete the life cycle in the roots of the resistant potato cultivar. In ‘Seresta’, the resistance response restricted the formation of females by avirulent individuals in favor of males. Oberlangen was virulent on all cultivars tested. No difference in cyst size, number of eggs per cyst, length of juveniles, and males was found for Oberlangen and Chavornay on the susceptible cv. ‘Desiree’. However, cysts of virulent populations from the same region Oberlangen was obtained from had a significantly larger diameter compared to avirulent populations. The population Oberlangen showed a higher reproduction and fitness than the reference population Chavornay on susceptible cultivars and could serve as a future reference population in testing of new potato cultivars for resistance against this new virulence type in Europe.
Momentum and contrarian effects in the Ukrainian stock market: case of daily overreactions
Authors: Plastun Alex , Strochenko Nataliya , Zhmaylova Olga , Sliusareva Liudmyla , Bashlay Sergiy
Published: February 2020

This paper examines momentum and contrarian effects in the Ukrainian stock market after one-day abnormal returns. To do this, UX futures data over the period 2010–2018 are used. The following hypotheses are tested: H1) hourly returns on overreaction days differ from hourly returns on normal days, H2) there are price patterns on overreaction days, and H3) to test these hypotheses, visual inspection and average analysis are used, as well as t-tests, cumulative abnormal returns, and trading simulation approaches. The results suggest that there are statistically significant differences between intraday dynamics during the usual days and the overreactions day. There is a strong momentum effect present on the day of overreaction: prices tend to change only in the direction of the overreaction during the whole day. The fact of the overreaction becomes clear after 13:00-14:00. This gives a lot of time to explore the momentum effect in the day of overreaction. On the day after the overreaction, prices tend to go in the opposite direction: contrarian pattern is detected, which is in line with the overreaction hypothesis. Based on detected price patterns, rules of trading and trading strategies for the Ukrainian stock market are developed. Momentum Strategy (based on price patterns on the day of overreaction) generates several successful trades; close to with 90%, and their number being is profitable (trading results differ from the random ones – confirmed by t-tests). Contrarian Strategy (based on price patterns on the day after the overreaction) demonstrates low efficiency, and results do not differ from random trading.
Employment in the financial sector of economy: features and trends
Authors: Paska Igor , Satyr Larysa , Zadorozhna Ruslana , Stadnik Leonid , Shevchenko Alla
Published: February 2020

The significant transformation of employment in terms of its quantitative and qualitative characteristics is a hallmark of the current labor market. Some labor market segments differ in the market condition, growth rates, and the mechanisms of adaptation to change. This article aims at analyzing employment trends in the domestic financial sector in the context of global labor market trends. The research is based on methodological approaches to the employment study of the International Labor Organization and the information of the State Statistics Service of Ukraine. The study found out that in the pre-crisis period, employment in financial activities increased at a faster rate than other types of economic activity. However, after 2008, the trend has reversed. The concentration ratio of employees of the financial and insurance activities in the capital and in economically developed regions is moderate and steadily increasing. A decrease in the intensity of vocational training and advanced training is the negative aspect of the crisis processes in the Ukrainian financial sector.
Reinventing Place-identity and Embracing New Economic Opportunities: Promoting Creative Economy of Sanur Through Public Participation
Authors: Gede Maha Putra Nyoman , Parama Putra Ida Bagus Gede
Published: February 2020

Every place on the planet has unique characters that make it distinguishable from other sites. Place-identity is the term widely accepted to explain this phenomenon. It is argued that the place-identity could not only strengthen the sense of belonging of the locals to a place and improve social cohesion but, in the age of global tourism, it could also increase the attractiveness of the place to visitors. Therefore, it contains economic values if managed in a proper way. But places are transforming. The dynamics of contemporary activities where tradition is seen as outdated, new government system, new economic activities, and new actors and their roles challenge the stability of place-identity. Unfortunately, the transformation of a place may benefit some actors but may trouble other groups.  Some places, however, maintain their place-identity for the social and economic values it holds. Collaboration among different actors in managing the transformation of such place could maintain the place-identity of a place which ensures its attractiveness to visitors, sustains its economic values amidst rapid changes.  The collaboration confirms no one is left behind.  The case study research conducted in Sanur showed that the sustained place-identity could economically benefit all actors.
An autonomous operational trajectory searching system for an economic and environmental membrane bioreactor plant using deep reinforcement learning
Authors: Nam KiJeon , Heo SungKu , Loy-Benitez Jorge , Ifaei Pouya , Yoo ChangKyoo
Published: February 2020

Optimal operation of membrane bioreactor (MBR) plants is crucial to save operational costs while satisfying legal effluent discharge requirements. The aeration process of MBR plants tends to use excessive energy for supplying air to micro-organisms. In the present study, a novel optimal aeration system is proposed for dynamic and robust optimization. Accordingly, a deep reinforcement learning (DRL)-based optimal operating system is proposed, so as to meet stringent discharge qualities while maximizing the system's energy efficiency. Additionally, it is compared with the manual system and conventional reinforcement learning (RL)-based systems. A deep Q-network (DQN) algorithm automatically learns how to operate the plant efficiently by finding an optimal trajectory to reduce the aeration energy without degrading the treated water quality. A full-scale MBR plant with the DQN-based autonomous aeration system can decrease the MBR's aeration energy consumption by 34% compared to other aeration systems while maintaining the treatment efficiency within effluent discharge limits.
Infraestructuras de Confianza y Sostenibilidad Una mirada a las relaciones entre sostenibilidad y estandarización en la política internacional de producción cafetera
Authors: Sanchez-Vargas Derly Yohanna
Published: February 2020

Este artículo presenta el aporte de los Estudios Sociales de la Ciencia y la Tecnología en la comprensión de las configuraciones sociales y técnicas que introducen los estándares de sostenibilidad en la producción de cafetera. Esta literatura hace énfasis en la importancia de entender las infraestructuras materiales y sociales que sostienen, a menudo de forma invisible, prácticas y órdenes institucionales. En el caso de la producción agrícola, una agenda política global que promueve la sostenibilidad ha atraído un conjunto de actores que prometen producción más sostenible a través de su estandarización. Este artículo explora el potencial analítico y empírico del estudio de los procesos de estandarización en café, especialmente en el caso de los sellos de sostenibilidad.
Review of MiRNA-Disease Association Prediction
Authors: Jiang Lei , Zhu Ji
Published: February 2020

:

Accumulating evidence demonstrates that miRNAs serve as critical biomarkers in various
complex human diseases. Thus, identifying potential miRNA-disease associations has become a hot
research topic for providing a better understanding of disease pathology, including cell carcinoma, cell
proliferation and mevalonate pathway. Recently, based on various biological datasets, more and more
computational prediction methods have been designed to uncover disease-related miRNAs for further
experimental validation. Due to the fact that different limitations exist in previous computational
methods, we proposed the model of Decision Template-based MiRNA-Disease Association prediction
(DTMDA) to prioritize potential related miRNAs for diseases of interest. By integrating miRNA functional
similarity network, miRNA Gaussian interaction profile kernel similarity network, two disease
semantic similarity networks and disease Gaussian interaction profile kernel similarity network, we
trained five multi-label K nearest neighbors-based core classifiers.
A Simple Synthesis of the Anticancer Drug Altretamine
Authors: Duong Vu Binh , Hien Pham Van , Ngoc Tran Thai , Chau Phan Dinh , Vu Tran Khac
Published: February 2020

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown
antitumor drug, has been successfully developed. The synthesis method involves the conversion
of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of
40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high
yield.
Regioselective IED Diels-Alder Reaction of Bis-(4,6-dichloro-[1,3,5]triazin- 2-yl)-diazene with Furan and Its Molecular Mechanism
Authors: Karkhut Andrew , Polovkovych Sviatoslav , Lesyk Roman , Novikov Volodymyr
Published: February 2020

The reaction of bis-(4,6-dichloro-[1,3,5]triazin-2-yl)-diazene with furan proceeds with the
formation of inverse electron demand Diels-Alder product with a high yield. M06 2X/6 31G(d,p) calculations
show thermodynamic instability of “normal” DA reaction product and predict its [3,3] sigmatropic
rearrangement to the thermodynamically more favorable formal IEDDA reaction product. The
obtained NMR spectra were in good agreement with GIAO calculations and were in accordance with
DFT thermochemical data that confirmed the formation of the described product. IR and UV/Vis spectral
data was also obtained and discussed.
Determination of Fundamental Medication Reconciliation Features with an International Perspective
Authors: Tafazoli Ali
Published: February 2020

Background:

Medication reconciliation is a major part of clinical care transitions that
can promote patient safety and satisfaction. The main administrators of this process are pharmacy
practitioners. Currently, many medical centers all over the world implement the procedures of
medication reconciliation with varying styles and inconsistent success. Some other centers are going
to build protocols in the near future. By now, there is no consensus for an optimal method of
running medication reconciliation and each center has its own approach. This fact can cause a huge
amount of resource wastages. In this narrative review, we searched scientific literature in this field
in order to extract, underline and formalize the specific features which help a medical center to
reach an optimized medication reconciliation plan.

Methods:

We explored the PubMed database with keywords of “medication reconciliation” and
“pharmacy service” to obtain a relevant reference pool for our topic. Then we checked the affiliations
of authors to be assured of the international diversity of our perspective.

Results:

Our search method yielded 184 journal articles from different continents. The frequency of
published articles from America was higher and then, Europe, Australia, Asia and Africa were
placed, respectively.

Conclusion:

According to the results, inclusion of factors like establishing phases for implementation,
proper education, developing academic coordination, providing suitable facilities, specialization
of the services, periodical evaluations and promoting pharmacy practice in the development of
medication reconciliation will potentially lead to an optimized plan.
Acknowledgement to reviewers 2019
Authors: Davids M. Razeen
Published: February 2020

The editors of AJN wish to thank the colleagues who generously gave of their time and expertise to review manuscripts for us during 2019. We greatly appreciate their contribution to the quality of the work that we publish.
Internalisasi nilai pendidikan kewarganegaraan pada tradisi pesta laut blanakan dalam rangka pengembangan ideal democratic citizen
Authors: Halimah Lili , Anisah Anisah
Published: February 2020

Pendidikan memiliki peranan yang penting dalam kehidupan manusia, dan diharapkan dapat menciptakan manusia yang berkualitas. Pendidikan Kewarganegaraan memiliki tiga kompetensi yang dapat  membentuk “the ideal democratic citizen” yakni kompetensi civic knowledge, civic skills, dan  civic disposition. Pembelajaran PPKn mengaitkan antara teori dengan praktek nyata di lapangan, dan berhubungan dengan nilai-nilai budaya yang beragam dan majemuk. Faktor yang mempengaruhi nilai budaya lokal dalam melestarikan kebudayaan melalui  upacara adat pesta laut Blanakan Kabupaten  Subang Jawa Barat yang dilakukan setahun sekali  guna  menghormati leluhurmya. Penelitian ini menggunakan pendekatan kualitatif. Hasil penelitian (a) Masyarakat nelayan memunculkan civic knowledge yang diarahkan oleh para tokoh, sehingga memiliki kesadaran untuk melestarikan nilai-nilai kebudayaan, yang mampu mengeksplorasi dan memanfaatkan potensi alam daerah, (b) Nilai-nilai dalam pesta laut, selalu memerlukan civic skill yang cakap dalam mengorganisasikan kegiatan, semua ini diperlukan partipatory skill, dan (c) Membentuk karakter masyarakat nelayan pada pesta laut, dengan cara memberi tahu dan mengajarkan hal-hal yang baik oleh para tokoh budaya. Dengan demikian perlu ditanamkan the ideal democratic citizen untuk meningkatkan kecintaan pada  nilai budaya lokal, dan tidak terpengaruh oleh budaya asing.----------------------------------------------------------- Internalization the value of citizenship education in the traditional sea party tradition (Pesta Laut Blanakan)  in order to develop the ideal democratic citizenEducation has an important role in human life and is expected to create quality human beings. Citizenship Education has three competencies that can form the ideal democratic citizen, namely civic knowledge, civic skills, and civic disposition competencies. PPKn learning links theory with real practice in the field, and deals with diverse and pluralistic cultural values. Factors that influence the value of local culture in preserving culture through the Blanakan Subang regency West Java regency traditional ceremony which is conducted annually to honor its ancestors. This study uses a qualitative approach. Research results (a) The fishing community raises civic knowledge directed by leaders, so that they have an awareness to preserve cultural values, which are able to explore and utilize the natural potential of the region, (b) Values in sea party, it always requires civic skills that competent in organizing activities, all of this requires participatory skills, and (c) forming the character of fishing communities at sea party, by telling and teaching good things by cultural leaders. Thus it is necessary to instill the ideal democratic citizen to increase the love of local cultural values, and not be influenced by foreign cultures.
Pemberdayaan penyandang disabilitas pada objek wisata Kuta Bali
Authors: Waruwu Dermawan , Adhi Ni Ketut Jeni
Published: February 2020

Penelitian ini mengkaji tentang jenis penyandang disabilitas dan bentuk pemberdayaan penyandang disabilitas pada objek wisata Kuta, Kabupaten Badung, Provinsi Bali. Masalah ini dianalisis secara kualitatif dengan pendekatan kajian budaya serta dikaji menggunakan teori hegemoni dan praktik sosial. Hasil penelitian menunjukkan: (1) jenis penyandang disabilitas yang diberdayakan pada objek wisata Kuta yaitu tunanetra dan dan tunadaksa; (2) bentuk pemberdayaan penyandang disabilitas yaitu cleaning service, tukang masak, operator CCTV, dan penjual pulsa keliling; (3) penyandang disabilitas kurang diberdayakan pada objek wisata Kuta, sehingga mereka menjadi kelompok yang termarginalkan dan terhegemoni ditengah geliat industri pariwisata. Pemerintah, pengusaha, dan masyarakat diharapkan agar memberdayakan penyandang disabilitas secara maksimal agar mereka memperoleh pekerjaan yang layak untuk keberlanjutan kehidupannya.---------------------------------------------------------------------------This study examines what types of people with disabilities and how to empower people with disabilities in the tourist attraction of Kuta, Badung Regency, Bali Province? This problem is analyzed qualitatively with a cultural study approach and examined using the theory of hegemony and social practice. The results of the study showed: (1) types of persons with disabilities who were empowered in Kuta's tourist objects, namely blind and disabled people; (2) forms of empowerment namely cleaning service, cooks, CCTV operators, and mobile credit sellers; (3) people with disabilities are less empowered in Kuta tourism objects, so they become the marginal group and hegemony in the midst of the stretch of the tourism industry. The government, employers, and the community are expected to empower persons with disabilities to the fullest so that they get decent jobs for the sustainability of their.
Online Health Information–Seeking Among Older Women With Chronic Illness: Analysis of the Women’s Health Initiative
Authors: Sedrak Mina S , Soto-Perez-De-Celis Enrique , Nelson Rebecca A , Liu Jennifer , Waring Molly E , Lane Dorothy S , Paskett Electra D , Chlebowski Rowan T
Published: February 2020

Background

Understanding how older patients with chronic illnesses use the internet to obtain health information is relevant for the design of digital interventions aimed at improving the health and well-being of adults aged 65 years and older; this cohort represents the sickest, most expensive, and fastest-growing segment of the US population.

Objective

The objective of our study was to describe online health information–seeking behavior among older patients with chronic illnesses and to compare the characteristics of patients who report using the internet to obtain health information with those who do not.

Methods

The study population included 72,806 women aged 65 years and older enrolled in the Women’s Health Initiative (WHI), a national cohort study, who completed a 2014 supplemental questionnaire assessing everyday technology use and internet use for researching health conditions. Comparisons were made between participants with and without a history of chronic illness and between users and nonusers of online sources for health information. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% CIs.

Results

Of the total, 59% (42,887/72,806) of older women used the internet for health information. Compared with women who did not use the internet to obtain health information, those who used the internet were younger (median age: 76 vs 81 years), more likely to be non-Hispanic white (90% [38,481/42,887] vs 87% [26,017/29,919]), earned a higher income (over $US 50,000: 55% [23,410/42,887] vs 33% [9991/29,919]), achieved a higher educational level (more than high school: 87% [37,493/42,887] vs 75% [22,377/29,919]), and were more likely to live with a partner (52% [22,457/42,887] vs 36% [10,759/29,919]) (all P<.001). Women with Alzheimer disease were least likely to report online health information–seeking compared to those without the disease (OR 0.41, 95% CI 0.38-0.43). In contrast, women with a recent diagnosis of cancer, within the previous 2 years (OR 1.23, 95% CI 1.11-1.36) or 2-5 years ago (OR 1.09, 95% CI 1.00-1.19), were most likely to use the internet for health information.

Conclusions

Nearly 6 in 10 older women participating in the WHI reported using the internet to obtain health information. Patients recently diagnosed with cancer are more likely to be looking for health information online, even after adjustment for age, suggesting that these patients may have a greater need for digital health resources.