bluuebunny/crossref_metadata_2025 huggingface dataset:
Turismo de bienestar como técnica de fidelización para atractivos turísticos: caso Tungurahua, Ecuador
Authors: Ramos Cevallos Moisés Elías , Chávez Yépez Howard Fabián
Published: August 2023

La provincia de Tungurahua presenta diversos atractivos que realizan prácticas de turismo de bienestar de forma involuntario, por ende, desconocen del concepto, importancia, beneficios e implicaciones del turismo de bienestar e incluso tienden a confundirlo con el turismo de salud. Por tanto, el objetivo de la presente investigación consiste en describir la situación del turismo de bienestar en los negocios y atractivos turísticos de la provincia de Tungurahua, a través del análisis de las dimensiones: condición física, estado mental y estado espiritual. El abordaje metodológico obedeció a una tipología descriptiva para detallar el comportamiento del turista y su fidelización con las prácticas del turismo de bienestar; el instrumento de recolección de datos fue una encuesta aplicada a 384 turistas tungurahuenses que hayan visitado negocios como hoteles y spa, aguas termales, caminata, medicina no tradicional, entre otros. Los principales resultados demuestran efectividad en las prácticas de turismo de bienestar para disminuir los niveles de estrés en los turistas, especialmente en la dimensión de condición física. Los principales cambios y mejoras fueron incremento de resistencia física con un 45,5%, refuerzo de creencias y valores con un 71,5% y mejora de concentración y atención con un 36,0%. También, existe un 62,0% de turistas fidelizados que desean realizar una próxima visita o estadía al negocio con una frecuencia estimada de cada 3 meses. Por tanto, el turismo de bienestar de Tungurahua posee facilidades para mejorar la condición física de los turistas, sin embargo, presenta moderadas complicaciones en mejorar el estado mental y espiritual.
El teorema fundamental del Cálculo: una versión contemporánea y la otra basada en las ideas de I. Barrow, utilizando GeoGebra
Authors: Zubieta Badillo Gonzalo
Published: August 2023

En la perspectiva de los registros de representación semiótica de R. Duval consideramos el Teorema Fundamental del Cálculo (TFC), en las dos versiones mencionadas en el título, ya que de acuerdo a Duval (pág. 127) " ... que toda representación es cognoscitivamente parcial en referencia a lo que ella representa y que de un registro a otro no son los mismos aspectos de un contenido los que son representados", motivo por el cual en el aprendizaje es de crucial importancia presentar en al menos dos registros de representación a dicho concepto. De lo anterior, pretendemos obtener algunas orientaciones didácticas que permitan un mejor aprendizaje para los estudiantes, de tan importante resultado.
Analizando las conexiones matemáticas de un futuro profesor de matemáticas al resolver problemas en una asignatura de Didáctica del Cálculo
Authors: Rodríguez-Nieto Camilo Andrés , Romero-Sierra Paula Andrea , Otero-Domínguez Natalia Carolina , Vega-Del Castillo Nayelis
Published: August 2023

Se analizaron las conexiones matemáticas que establece un futuro profesor de matemáticas cuando resuelve un problema de aplicación sobre derivadas. El estudio se fundamentó en la Teoría Ampliada de las Conexiones (TAC) y la metodología fue cualitativa desarrollada en tres etapas: 1) selección de los participantes, 2) realización de una observación participante en un curso de Didáctica del Cálculo en una Universidad pública colombiana, 3) ejecución de un análisis temático de los datos. Los principales resultados muestran que el futuro profesor estableció conexiones orientadas a la instrucción, significado, modelado, procedimental, características, representaciones diferentes e implicación, con el fin de resolver y explicar un problema de aplicación sobre el volumen de una caja y son la evidencia especial de su comprensión. Es importante que tanto el profesor como los estudiantes fomenten las conexiones al momento de resolver problemas y reflejen alto nivel de comprensión de los conceptos de Cálculo.
Analysis of Working Capital Turnover on Profitability: A Case from PT Telekomunikasi Indonesia, Tbk
Authors: Aslam Annisa Paramaswary
Published: August 2023

This study aims to analysis about the turnover of working capital on profitability at PT. Telekomunikasi Indonesia Tbk. In addition, this study purpose to know about the impact of The Covid-19 for the telecommunications sector. The pandemic has changed the needs and lifestyles of people who rely heavily on internet access and the government's hard work to uniformly distribute digital infrastructure across Indonesia. The sample set is the balance sheet and income statement at PT Telekomunikasi Indonesia Tbk for the 2015-2021. The data used in this research is secondary data from the published financial reports of PT. Telekomunikasi Indonesia Tbk through the Indonesia Stock Exchange (IDX) website.  The results showed that high working capital turnover was not followed by a high level of profitability, and working capital turnover was low it resulted in a high level of profitability.
The Effect of Service Quality on Customer Satisfaction Using Goods Delivery Services in Makassar City
Authors: Hasdiansa Ilma Wulansari , Hasbiah Sitti
Published: August 2023

This study aims to determine whether the dimensions of service quality, namely tangible, reliability, responsiveness, assurance, and empathy affect customer satisfaction of Goods Delivery Services in Makassar City and analyze the most dominant factors in influencing customer satisfaction of Goods Delivery Services in Makassar City. The population in this study were all customers at the Goods Delivery Service in Makassar City, totaling 8544. The sample taken was 100 respondents using Non-Probability Sampling technique with Purposive sampling approach. The results showed that all independent variables each had a positive and significant effect on the dependent variable. Simultaneously all service quality variables have a positive and significant influence on customer satisfaction. Goods Delivery Services in Makassar City need to maintain elements that have been rated well by customers such as empathy, tangible, and responsiveness, on the other hand, they need to improve things that are still lacking, namely assurance.
Analysis of Segmentation, Targeting, and Positioning (STP) Determination on Sales Volume at Cafe Teras Empang Parepare City
Authors: Ilham Abu  , Ridwan
Published: August 2023

This study aims to assess and analyze whether the STP (Segmentation, Targeting, and Positioning) marketing strategy on the sales volume that has been implemented by Cafe Teras Empang in Parepare City has reached approximately one year (2021-2022). This type of research is descriptive quantitative. The population in this study were all employees of Cafe Teras Empang while the sample of this study were all 36 employees of Cafe Teras Empang as respondents using saturated sampling, which is a sampling technique when all members of the population are used as samples. The data collection techniques were carried out by means of questionnaires conducting interviews and questionnaires. While the data analysis technique used is to use Multiple Linear Regression Analysis using two statistical test methods, namely Simultaneous Test (Test f). Based on the results of research with statistical data analysis, the indicators in this study are valid and the variables are reliable. In the classical assumption test, it is proven that all indicators are normally distributed and there is a significant linear relationship between each independent variable and the dependent variable, for influence Segmentation, Targeting, and Positioning all have a positive direction and are not significant in their influence on the sales volume at Cafe Teras Empang in Parepare City.
Storks and Jars: Within the World of Surrogacy Narratives
Authors: Korytowska Olga
Published: August 2023

By analyzing public accounts of the experiences of surrogates and intended parents, this article aims at identifying popular American discourses on surrogacy, which remains a contested assisted reproduction technology. Focusing on first-person narratives, I look at the strategies of rationalization employed by people entering commercial surrogacy contracts, particularly in relation to the monetary exchange. I argue that even though the ethics of financial compensation is not questioned in most narratives by surrogates and intended mothers, the normalizing discourse on American surrogacy requires the issue of money to be downplayed – instead surrogacy is presented as an altruistic “gift of life.”
Allen Iverson: Celebrity and the Event
Authors: Muniowski Łukasz
Published: August 2023

Allen Iverson can be characterized as an event, because listed at 6 feet and weighing just 165 pounds, he won four scoring titles in his NBA career, and was one of the best shooting guards in the history of the league. Small, quick and explosive, he was an exceptional talent with a complicated personality. Iverson was a trendsetter, as important off as he was on the court. He was a villain, but one that was “cool” enough to root for. His basketball career is best summed up by two events, which occurred just a year apart. One was his memorable crossover and shot in overtime of Game One of the 2001 Finals, the other was Iverson’s press conference a year later, known now as “The Practice Rant.” This article will analyze both of these events with the aid of various critical texts, most notably by Slavoj Žižek. It will explain their significance to the modern shape of the NBA, how they influenced players that joined the league after Iverson. In doing so, it will establish AI as an important, truly revolutionary event – a force that influenced not only basketball culture, but modern America.
Hidden Curriculum Activities on Numeracy and Literacy Development in Early Grade Education: Perspectives from Elementary School Teachers in Ghana
Authors: Atteh Evans , Kwofie Winnifred , Martin Georgina , Boakye Anthony
Published: August 2023

This paper synthesizes the perspectives of five elementary school instructors on hidden curriculum activities in basic education in Ghana. These opinions were expressed during an interview conducted to determine the effect of a hidden curriculum on the development of numeracy and literacy among Ghana's early-grade learners. Qualitative analysis was used to analyze the data collected through open-ended queries and semi-structured interviews. The findings of this study indicated that early-grade educators are well aware of hidden curriculum activities and engage in various extracurricular activities to develop their pupils' numeracy and literacy skills. Therefore, the hidden curriculum contributes to a more holistic education by expanding the scope of learning beyond the curriculum's prescribed subjects. The study concludes with suggestions that education is not limited to textbooks and lesson plans but includes a wide range of experiences that shape learners' perspectives, skills, and character development; therefore, teachers should provide an environment that creates learning opportunities for students to improve retention, engagement, and enjoyment of the learning process.
Assessement of Geohelminth Contamination of Playground and Sanitation Compliance among Primary Schools in Akwa Ibom State’s Rural Area
Authors: Adams E. G. , Usip L. P. , Opara K. N. , Mbong E. O. , Yaro C. A. , Asuquo A.
Published: August 2023

The study was carried out to assess the level of geohelminth contamination in playgrounds of six Government Primary School (GPS) randomly selected within the three districts of Akwa Ibom State and also their state of compliance on sanitation in order to ensure a child-friendly learning environment. Soil samples were collected and analyzed using the zinc sulphate floatation method and the Baermann technique while sanitation facility compliance was assessed using structured checklist which was subjected to Water Access, Sanitation and Hygiene (WASH) grading criteria for sanitation. Out of 300 soil samples analyzed, a 22% contamination rate was recorded, with Ascaris lumbricoides being the most encountered. Toxocara canis and Taenia sp. were also encountered in the study which are associated with visceral larval migran and cysticercosis, respectively. Sanitation compliance rate recorded was 68.8% which revealed that the existing facilities in the public primary schools in the area need improvement. A high level of improper fecal disposal and also the potential risk of geohelminthiasis and zoonotic diseases among pupils in the schools were revealed in the study as such, health education and awareness is advocated alongside strategies for the provision and sustainable use of sanitation facilities in schools.
Nutri-hormonal Manipulation for Yield and Quality Improvement in Guava (Psidium guajava L.)
Authors: Ishwariya R. , Sivakumar V. , Shanmugasundaram K. A. , Vanitha K. , Seenivasan N. , Muthuvel I.
Published: August 2023

Aims: To study the effect of nutrients and plant growth regulators through foliar spray on yield and quality characteristics of guava var. Arka Kiran.

Study design:  Randomized Block Design (RBD).

Place and Duration of Study: The experimental trial was conducted at a Farmer’s field in Theethipalayam village of Coimbatore district, Tamil Nadu during 2022-2023.

Methodology: The current study included six treatments and three replications. Three-year-old guava trees with uniform size, growth, and bearing habit were chosen for imposing treatments. Observations on fruit yield, physical and quality characteristics of guava were recorded.

Results: Fruit diameter (6.30 cm), Fruit weight (168.17 g), fruit volume (146.46 ml), fruit yield (16.53 kg/tree) and the number of fruits per tree (98.35) were recorded maximum in plants treated with nutri-hormonal spray-I. The best-quality fruits in terms of increased TSS (12.08), ascorbic acid (185.35 mg/g), reducing (3.15%), non-reducing (4.19%), and total sugars (7.35%) and reduced acidity (0.40%) were also recorded in the same combination.

Conclusion: The foliar application of nutrients and PGRs spray-I can be advocated to improve the yield and quality attributes of guava.
Pharmacognostic Evaluation of the Leaves of Coccinia barteri Hook F (Cucurbitaceae)
Authors: Obinna Onugwu Sabastine , Ebele Obi Patrick , Linda Onugwu Adaeze
Published: August 2023

Background: In general, Coccinia barteri is offered and sold in its raw form. This natural form could be adulterated, substituted, or contaminated. Therefore, the purpose of this study is to use pharmacognostic analyses to verify the authenticity of the leaves of the Coccinia barteri plant.

Methods: The organoleptic studies were carried out through sensory organs. Histological analyses were conducted by microscopic examination of the specimen mounted on hand slides. Phytochemical screening and chemomicroscopic evaluation were also carried out using various standard methods.

Results: The leaves of Coccinia barteri come in a range of forms and sizes. They are lustrous, bright, and dark green. They are also tiny and feature opposite imparipinnate compound leaves. The organoleptic evaluation showed a leafy odour and an astringent taste. Microscopic evaluation showed glandular trichomes, wavy epidermal cells, and anomocytic stomata. The leaf had anomocytic stomata and hypostomatic. with an average stomatal number, index, density, length, width and size of 13.75 ± 0.40%, 15.44 ± 0.42 mm-2, 80.88±2.82 mm-2, 29.26µm, 26.17 ± 0.4 µm and 766.38± 39.49 µm, respectively.

The phytochemical screening revealed the presence of phenols, terpenoids, saponins, alkaloids, proteins, glycosides, and flavonoids, while tannins and fixed oils were not detected. Chemotaxonomic studies showed the presence of starch grains, lignified tissues, calcium oxalates, gum, and the absence of protein and oil globules.

Analytical evaluation of the leaves of Coccinia barteri produced 7.00% total ash, 0.93% acid insoluble ash, 2.96% water soluble ash, 8.40% moisture content, 29.67% alcohol extractive value, 40.17% water extractive value, and 21.00% ethyl acetate extractive value.

Conclusion: This study provides information on the morphology, microscopic, and phytochemical profile of the leaves of Coccinia barteri.
Assessment of Agricultural Practices Impact on the Development of Arbuscular Mycorrhizal Fungi
Authors: Brahima Ouattara , Sibirina Soro , Abdoulaye Koné N’golo , Nakpalo Silué , Daouda Koné
Published: August 2023

In natural environments, the development of plants depends on the interactions they maintain with their environment, in particular with soil microorganisms such as arbuscular  mycorrhizal fungi, especially since the used of inputs is scarce by the majority of farmers in Côte d’Ivoire. The present study was carried out to study the endomycorrhizogenic potential of the soils on which tomato, cashew and banana are grown. Place and Duration of Study: Soil sampling in bananas, cashews and tomatoes fields (July and August 2016), spore trapping in WASCAL (West African Science Service Center on Climate Change and Adapted Land Use) greenhouse in the city of Bingerville and spore extraction and identification in Laboratory of Biotechnology, Agriculture and Development of Biological Resources (September 2016 to March 2017).  Material and Methods: Soil samples were taken away from the same depth, 10 to 20 cm, in cashew, tomato or banana fields. They were then used for trap pot culture by sorghum [Sorghum bicolor (L.)] and cowpea [Vigna ungugulata (L.) Walp.]. The wet sieving revealed spore density and morphological diversity. Results: Spores were more abundant in the soils sampled under cashew (22 spores / gram of soil) in comparison to banana (9 spores / gram of soil) and tomato (3 spores / gram of soil). There were a real diversity of glomeromycete in the different agrosystems. There is a great richness and diversity of AMF spore form under cashew (18 morphotypes) in Côte d'Ivoire compared to tomato (2 morphotypes) and banana (4 morphotypes). Conclusion: Land use system impact spore richness and diversity. Controlled mycorrhization of cashew, tomato and banana could be considered.
Prognostic Factors and Survival Outcomes Among Patients With Mycosis Fungoides in China
Authors: Chen Zhuojing , Lin Yuwei , Qin Yao , Qu Hui , Zhang Qiuli , Li Yingyi , Wen Yujie , Sun Jingru , Tu Ping , Gao Pei , Wang Yang
Published: August 2023

Importance

There are limited prognostic statistics and data available on survival outcomes for patients with mycosis fungoides (MF) in Asia.

Objective

To determine the prognostic factors and survival outcomes of patients with MF among a cohort in China.

Design, Setting, and Participants

This was a retrospective cohort study of patients with MF who received treatment at a tertiary referral center for skin lymphoma (Peking University First Hospital, Beijing, China) from August 1, 2009, to August 31, 2021. Data were analyzed from September 1, 2021, to December 31, 2022.

Main Outcomes and Measures

Overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS); for prognostic factors, hazard ratios (HRs), and adjusted HRs (aHRs; adjusted for sex, age, and overall TNMB [tumor, node, metastasis, blood] stage) determined using the Cox proportional hazards model.

Results

The study cohort comprised 461 patients with MF (median [range] age at diagnosis, 46 [5-87] years; 275 [59.7%] men and 186 [40.3%] women; 461 [100%] Chinese). The overall 5-year rate was 82.2% for OS, 83.5% for DSS, and 79.6% for PFS. Stage-specific 5-year OS rates were 95.7% for stage IA, 93.2% for IB, 95.7% for IIA, 70.1% for IIB, 55.3% for III, and 23.6% for IV. Compared with a UK cohort, our Chinese cohort had a younger median age at diagnosis (46 years vs 54 years) and a more favorable 5-year OS (82.2% vs 75.0%); however, after adjusting for age, the discrepancy in the 5-year OS rate was diminished (77.3% vs 76.4%). Cox models revealed that unfavorable predictors of OS, PFS, and DSS, respectively, were: age older than 60 years (aHR [95% CI], 2.25 [1.28-3.96]; 2.09 [1.16-3.76]; 2.27 [1.39-3.72]); advanced TNMB stage; advanced overall stage; large-cell transformation (aHR [95% CI], 2.16 [1.17-3.99]; 2.29 [1.21-4.33]; 2.21 [1.26-3.86]); and elevated lactate dehydrogenase levels (aHR [95% CI], 3.92 [1.64-9.36]; 4.77 [1.86-12.22]; 5.05 [2.23-11.42]). Biological sex and plaque lesion type were not associated with prognosis among this study cohort.

Conclusion and Relevance

The findings of this retrospective cohort study of patients with MF in China suggest that Asian patients are diagnosed at a younger age and have a higher 5-year OS compared with patients of other races in studies in other countries (predominantly White). Prognostic factors were similar to those of previous studies, except for patient sex and plaque lesion type.
Posttraumatic Stress Disorder Among Residents of Conflict-Affected Towns
Authors: Moges Solomon , Molla Gebeyaw , Mekuria Kindie , Molla Niguss , Girmaw Fentaw
Published: August 2023

This cross-sectional study assesses the prevalence of and risk factors associated with posttraumatic stress disorder in a large conflict-affected area in Ethiopia.
Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF‐α, IL‐1β and IL‐10 secretion from monocytic cells
Authors: Ogbodo Emmanuel , Michelangeli Francesco , Williams John H. H.
Published: August 2023

Endogenous molecules, such as heat shock proteins (HSP), can function as danger signals when released into the extracellular environment in response to cell stress, where they elicit an immune response such as cytokine secretion. There has also been some suggestion that contamination of exogenous HSPs with lipopolysaccharide (LPS) may be responsible for these effects. This study investigates the effects of exogenous HSPA1A and HSPB1 on the activation of immune cells and the resulting secretion of cytokines, which are involved in inflammatory responses. To address whether exogenous HSPs can directly activate cytokine secretion, naïve U937 cells, differentiated U937 cells and peripheral blood mononuclear cells (PBMCs) were treated with either exogenously applied HSPA1A or HSPB1 and then secreted IL‐1β, TNF‐α and IL‐10 were measured by ELISA. Both HSPs were able to induce a dose‐dependent increase in IL‐10 secretion from naïve U937 cells and dose‐dependent IL‐1β, TNF‐α and IL‐10 secretion were also observed in differentiated U937 cells and PBMCs. We also observed that CD14 affects the secretion levels of IL‐1β, TNF‐α and IL‐10 from cells in response to exogenous HSP treatment. In addition, HSPA1A and HSPB1 were shown to interact with CD14, CD36 and CD11b extracellular receptor proteins. Several approaches used in this study indicate that HSP‐induced cytokine secretion is largely independent of any contaminating LPS in the samples.
Nanozyme‐Cosmetic Contact Lenses for Ocular Surface Disease Prevention
Authors: Liu Quanyi , Zhao Sheng , Zhang Yihong , Fang Qi , Liu Wanling , Wu Rong , Wei Gen , Wei Hui , Du Yan
Published: August 2023

Efficiently balancing excess reactive oxygen species (ROS) caused by various factors on the ocular surface is a promising strategy for preventing the development of ocular surface diseases (OSDs). Nevertheless, the conventional topical administration of antioxidants is limited in efficacy due to poor absorption, rapid metabolism, and irreversible depletion, which impede their performance. To address this issue, contact lenses embedded with antioxidant nanozymes that can continuously scavenge ROS, thereby providing an excellent preventive effect against OSDs are developed. Specifically, Prussian blue family nanozymes are chosen based on their multiple antioxidant enzyme‐like activities and excellent biocompatibility. The diverse range of colors made them promising candidates for the development of cosmetic contact lenses (CCLs) as a substitute for conventional pigments. The efficacy of nanozyme‐CCLs is demonstrated in rabbits and rats exposed to a high risk of developing OSDs. These OSDs' prevention nanozyme‐CCLs can pave the way for CCLs toward powerful wearable biomedical devices and provide novel strategies for the rational utilization of nanomaterials in clinical practice.
Remote Selective C−H Halogenation of Arylphosphine Oxides with Ferric Halides
Authors: Yu Hong , Lin Xiuhua , Xu Guang , Yin Tingrui , Zhang Ying , Liu Jinpeng , Chen Jian , Meng Sixuan , Yuan Jia , Dang Li , Yu Guang‐Ao
Published: August 2023

We developed the remote selective C−H bromination for the synthesis of C4′‐brominated biarylphosphine oxides using FeBr3 as a brominating reagent. C3′‐Brominated products were obtained in reactions with substrates bearing a 2,4,6‐triisopropyl substituent on the bottom ring. Moreover, direct access to C5‐chlorinated peri‐substituted(1‐naphthalenyl)phosphines is developed using FeCl3 as a chlorinating reagent. These halogenated compounds can be utilized for cross‐coupling reactions to construct functionalized phosphine oxides.
Traceless Directing Group Enabled One‐Pot Regiospecific Synthesis of 2,3‐Diaryl‐4‐Fluoropyrroles
Authors: Wang Dan , Tian Yu‐Ting , Nie Jing , Jasiński Marcin , Tang Xiaodong , Ma Jun‐An
Published: August 2023

We describe a traceless group directed one‐pot regiospecific cycloaddition strategy to construct 4‐fluorinated pyrroles, which showcased promising anti‐inflammatory activity previously. By taking advantage of this protocol, a range of 4‐fluoropyrroles which are inaccessible via previous methods can be obtained, and a tentative reaction mechanism was proposed based on observed intermediates.
Synthesis of 5‐Trifluoromethylpyrroles from Heating‐Induced Annulation of Pyridinium 1,4‐Zwitterionic Thiolates with CF3‐Imidoyl Sulfoxonium Ylides
Authors: Ling Sihao , Zhang Yu , Chen Zhengkai , Wu Xiao‐Feng
Published: August 2023

A heating‐induced desulfuration annulation of pyridinium 1,4‐zwitterionic thiolates and CF3‐substituted imidoyl sulfoxonium ylides has been achieved, allowing a route to biologically important 5‐trifluoromethylpyrroles. The transformation proceeds through an unusual ((3+3)‐1) pathway under metal‐free conditions with the extrusion of 4‐methoxypyridine, sulfur and DMSO. The scale‐up reaction and further transformation of the obtained pyrrole products have been performed to demonstrate the synthetic utility of the developed method.
Syntheses and Structures of 5‐Membered Heterocycles Featuring 1,2‐Diphospha‐1,3‐Butadiene and Its Radical Anion
Authors: Sharma Mahendra K. , Weinert Hanns M. , Li Bin , Wölper Christoph , Henthorn Justin T. , Cutsail George E. , Haberhauer Gebhard , Schulz Stephan
Published: August 2023

LGa(P2OC)cAAC2features a 1,2‐diphospha‐1,3‐butadiene unit with a delocalized π‐type HOMO and a π*‐type LUMO according to DFT calculations. [LGa(P2OC)cAAC][K(DB‐18‐c‐6)]3[K(DB‐18‐c‐6] containing the 1,2‐diphospha‐1,3‐butadiene radical anion3⋅−was isolated from the reaction of2with KC8and dibenzo‐18‐crown‐6.3reacted with [Fc][B(C6F5)4] (Fc=ferrocenium) to2and with TEMPO to [L−HGa(P2OC)cAAC][K(DB‐18‐c‐6)]4[K(DB‐18‐c‐6] containing the 1,2‐diphospha‐1,3‐butadiene anion4−. The solid state structures of2,3K(DB‐18‐c‐6], and4[K(DB‐18‐c‐6] were determined by single crystal X‐ray diffraction (sc‐XRD).
Selektivitätskontrolle des Ligandenaustauschs am Kohlenstoff in α‐metallierten Yliden als Zugang zu Ketenylanionen**
Authors: Krischer Felix , Jörges Mike , Leung Tsz‐Fai , Darmandeh Heidar , Gessner Viktoria H.
Published: August 2023

Kürzlich berichteten wir, dass α‐metallierte Ylide einen Phosphan‐CO‐Ligandenaustausch eingehen und darüber Zugang zu isolierbaren Ketenylanion liefern. Systematische Studien an Tosyl‐substituierten Yldiiden der Form R3P=C(M)Ts (M=Li, Na, K) zeigen nun, dass die Carbonylierung auch zu einer konkurrierenden Metallsalzeliminierung (MTs) führen kann. Diese Nebenreaktion kann durch die Wahl des Phosphans, des Metallkations, des Lösungsmittels und der Zugabe geeigneter Coliganden kontrolliert werden, was die selektive Isolierung des Ketenylanions [Ts−CCO]M (2‐M) ermöglicht. Die Komplexierung von 2‐Na durch Kronenethern oder Kryptanden ermöglichte zudem die Strukturaufklärung des ersten freien Ketenylanions [Ts−CCO], welches eine annähernd lineare S−C−O‐Einheit aufweist, was auf einen höheren Anteil der Ynolat‐Grenzstruktur hindeutet. DFT‐Studien zeigen jedoch eine hohe negative Ladung am Ketenylkohlenstoff, was sich in der selektiven Reaktivität am C1‐Atom widerspiegelt. Die vorgestellten Ergebnisse liefern wichtige Informationen über die Selektivitätskontrolle der Carbonylierung von α‐metallierten Ylide, was für künftige Anwendungen unabdingbar ist.
Polymeric Carbon Nitride with Chirality Inherited from Supramolecular Assemblies
Authors: Azoulay Adi , Aloni Sapir Shekef , Xing Lidan , Tashakory Ayelet , Mastai Yitzhak , Shalom Menny
Published: August 2023

The facile synthesis of chiral materials is of paramount importance for various applications. Supramolecular preorganization of monomers for thermal polymerization has been proven as an effective tool to synthesize carbon and carbon nitride‐based (CN) materials with ordered morphology and controlled properties. However, the transfer of an intrinsic chemical property, such as chirality from supramolecular assemblies to the final material after thermal condensation, was not shown. Here, we report the large‐scale synthesis of chiral CN materials capable of enantioselective recognition. To achieve this, we designed supramolecular assemblies with a chiral center that remains intact at elevated temperatures. The optimized chiral CN demonstrates an enantiomeric preference of ca. 14 %; CN electrodes were also prepared and show stereoselective interactions with enantiomeric probes in electrochemical measurements. By adding chirality to the properties transferrable from monomers to the final product of a thermal polymerization, this study confirms the potential of using supramolecular precursors to produce carbon and CN materials and electrodes with designed chemical properties.
Syntheses and Structures of 5‐Membered Heterocycles Featuring 1,2‐Diphospha‐1,3‐Butadiene and Its Radical Anion
Authors: Sharma Mahendra K. , Weinert Hanns M. , Li Bin , Wölper Christoph , Henthorn Justin T. , Cutsail George E. , Haberhauer Gebhard , Schulz Stephan
Published: August 2023

LGa(P2OC)cAAC 2 features a 1,2‐diphospha‐1,3‐butadiene unit with a delocalized π‐type HOMO and a π*‐type LUMO according to DFT calculations. [LGa(P2OC)cAAC][K(DB‐18‐c‐6)] 3[K(DB‐18‐c‐6] containing the 1,2‐diphospha‐1,3‐butadiene radical anion 3⋅− was isolated from the reaction of 2 with KC8 and dibenzo‐18‐crown‐6. 3 reacted with [Fc][B(C6F5)4] (Fc=ferrocenium) to 2 and with TEMPO to [L−HGa(P2OC)cAAC][K(DB‐18‐c‐6)] 4[K(DB‐18‐c‐6] containing the 1,2‐diphospha‐1,3‐butadiene anion 4−. The solid state structures of 2, 3K(DB‐18‐c‐6], and 4[K(DB‐18‐c‐6] were determined by single crystal X‐ray diffraction (sc‐XRD).
Selectivity Control of the Ligand Exchange at Carbon in α‐Metallated Ylides as a Route to Ketenyl Anions**
Authors: Krischer Felix , Jörges Mike , Leung Tsz‐Fai , Darmandeh Heidar , Gessner Viktoria H.
Published: August 2023

α‐Metallated ylides have recently been reported to undergo phosphine by CO exchange at the ylidic carbon atom to form isolable ketenyl anions. Systematic studies on the tosyl‐substituted yldiides, R3P=C(M)Ts (M=Li, Na, K), now reveal that carbonylation may lead to a competing metal salt (MTs) elimination. This side‐reaction can be controlled by the choice of phosphine, metal cation, solvent and co‐ligands, thus enabling the selective isolation of the ketenyl anion [Ts−CCO]M (2‐M). Complexation of 2‐Na by crown ether or cryptand allowed structure elucidation of the first free ketenyl anion [Ts−CCO]−, which showed an almost linear Ts−C−C linkage indicative for a pronounced ynolate character. However, DFT studies support a high charge at the ketenyl carbon atom, which is reflected in the selective carbon‐centered reactivity. Overall, the present study provides important information on the selectivity control of ketenyl anion formation which will be crucial for future applications.
Controlled Radical Copolymerization toward Well‐Defined Fluoropolymers
Authors: Chen Kaixuan , Guo Xing , Chen Mao
Published: August 2023

In the past 80 years, fluoropolymers have found broad applications in both industrial and academic settings, owing to their unique physicochemical properties. Copolymerizations of fluoroalkene feedstocks present an important avenue to obtain high‐performance materials by merging intrinsic attributes of fluorocarbons and great versatility of comonomers. Recently, while massive investigations have disclosed the great potentials of precisely synthesized polymers, researchers have made considerable efforts to approach well‐defined fluorinated copolymers. This minireview discusses challenges in controlled radical copolymerizations (CRCPs) of fluoroalkenes and provides a concise perspective on recent progress in CRCPs of fluoroalkenes (e.g., tetrafluoroethylene, chlorotrifluoroethylene, hexafluoropropene, perfluoroalkyl vinyl ethers) with non‐fluorinated vinyl comonomers, which have enabled on‐demand preparations of various main‐chain fluoropolymers with predefined molar masses, low dispersities, as well as regulable chemical compositions and sequences. The synthetic advantages of CRCPs will promote controlled and facile access to customized fluoropolymers for high‐tech applications such as batteries, coatings and so on.
Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes
Authors: Matchide Marie Germaine T. , Hnin Saw Yu Yu , Nguekeu Yves M. Mba , Matheuda Elodie Gaële , Nghokeng Josker , Tabakam Gaetan T. , Djoumbissie Raymonde A. Dzatie , Ngouela Silvère Augustin , Lee Yuan‐E , Tene Mathieu , Morita Hiroyuki , Awouafack Maurice Ducret
Published: August 2023

A new fructofuranoside glycerol, dryoptkirbioside (1), along with thirteen known compounds (2‐14), was isolated from the MeOH extract of Dryopteris kirbi rhizomes by silica gel column chromatography, Sephadex LH‐20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high‐resolution electrospray ionisation mass spectrometry (HR‐ESI‐MS) and chemical conversions. The hexane‐soluble portion and the EAFA fraction showed strong activities against lung (A549), breast (MCF‐7), and cervical (HeLa) human cancer cell lines (IC50 values ranging from 4.0 to 8.8 μg/mL). Aspidinol P (5) and aspidinol B (6) exhibited moderate to low cytotoxicity on the three cell lines (IC50 values ranging from 20.4 to 58.7 μM). The MeOH extract and hexane‐soluble portion had excellent activities against Staphylococcus aureus and Bacillus subtilis (MICs 11.7 and 23.4 μg/mL), whereas the AcOEt‐ and BuOH‐soluble portions were significantly active on S. aureus (MICs 46.9 and 93.8 μg/mL). The main fractions EAFB, EAFC and nBFB displayed excellent activity against S. aureus (MICs 11.7 and 23.4 μg/mL). Aspidinol B (6) had significant activity, while aspidinol P (5) was moderately active against S. aureus and B. subtilis (MICs 42.0 and 89.5 μM).
Noncalcifying type of calcifying epithelial odontogenic tumor: A rare case report and literature review
Authors: Zouaghi Hela , Garma Maroua , Slim Afef , Chokri Abdellatif , Njima Manel , Selmi Jamil
Published: August 2023

Key Clinical Message

There has been a recent spike in reporting of noncalcifying variants of CEOT with the WHO 2022 classification of head and neck tumors. The present case describes a rare histopathological variant of CEOT of which a handful of cases have been reported.

This work aimed to report a rare case of noncalcifying type of Pindborg Tumor involving the right mandible. The absence of calcifications in the calcifying epithelial odontogenic tumor presents a diagnostic challenge and prognostic implications. A literature review of the 16 reported clinical cases of this scarce variant was performed.
Thermochromic Hydrogels with Opaque‐Transparent Gradient Transition for Switchable Window and Temperature Monitor
Authors: Gao Yang , Li Kunming , Ren Xiuyan , Gao Guanghui
Published: August 2023

In recent years, the thermochromic hydrogel was acted as suitable sandwiching material to adjust light transmission. However, to accurately control the thermochromic temperature in a wide range still was a significant challenge. Here, a simple method was explored to prepare hydrogels with gradient opaque‐transparent transition thermochromic temperature from 5 °C to 53 °C, which was regulated by the aggregation state of sodium dodecyl sulfate micelles by adding potassium tartrate hemihydrate and cations. Using Li+, Na+, and K+ as cations, the accuracy was controlled at 1 °C. Moreover, the transmittance of the hydrogel was not changed when the thermochromic temperature was adjusted. As a result, an intelligent window was fabricated by utilizing thermochromic hydrogel as a sandwiching layer into the outer glass layers, which could effectively and stably regulate the visible and infrared light. The temperature monitors/detectors were also designed, which showed excellent temperature monitoring/detecting ability. Therefore, this low‐cost, high‐efficient, large‐scale prepared thermochromic hydrogel provided more potential for intelligent temperature devices.
Iron‐Catalyzed Alkenylzincation of Internal Alkynes†
Authors: Wang Wei‐Na , Huang Qiang , Jin Ye , Zhou Qi‐Lin , Zhu Shou‐Fei
Published: August 2023

Comprehensive Summary

The alkenylzincation of internal alkynes is an effective method for the synthesis of multi‐substituted conjugated dienes; however, the current catalytic systems for this reaction are limited in terms of substrate scope and selectivity control, which restricts its practical applications. Herein, we report the first iron‐catalyzed alkenylzincation of internal alkynes, which features mild conditions, simple operation, broad substrate scope (including aryl/alkyl, diaryl, and dialkyl acetylenes), excellent functional group tolerance (tolerating highly active functional groups such as ester, methylthio, amide, sulfonyl, cyano, etc.), and high activity (with a turnover number of up to 11500, the highest record for carbometallation reactions). Notably, the catalytic system described in this article also realized the highly selective vinylzincation of unfunctionalized internal alkynes as well as the alkenylzincation of unsymmetrical diarylacetylenes and dialkyl acetylenes, which have not been achieved with other catalytic systems reported in the literatures. The current study provides a highly selective access to synthetically important multi‐substituted conjugated dienes.
European Plant Cytoskeletal Club meeting: A vital platform for advancing plant cytoskeleton research
Authors: Bürstenbinder Katharina , Schwarzerová Kateřina
Published: August 2023

This contribution reports on a meeting of plant cytoskeleton scientists—the European Plant Cytoskeletal Club 2023 conference.
A Series of Cobalt bis(Thiosemicarbazone) Catalysts for Effective Photocatalytic Hydrogen Evolution Reaction
Authors: Papadakis Michael , Landrou Georgios , Poisson Marie , Delmotte Léa , Achileos Katerina , Bertaina Sylvain , Hardré Renaud , Ladomenou Kalliopi , Coutsolelos Athanassios G. , Orio Maylis
Published: August 2023

In order to diminish environmental issues such as global warming due to increased carbo dioxide (CO2) emissions, considerable efforts have been made in the research community. Photocatalytic hydrogen (H2) production is a very important way towards this goal, since sunlight is an abundant source of energy and H2 is a clean fuel, producing no greenhouse gases. Inexpensive, stable and non‐toxic carbon dots were easily synthesized and used as photosensitizers in water in the presence of a series of molecular cobalt catalysts (CoTSC). The catalysts were thiosemicarbazone‐based complexes able to transfer electrons for hydrogen evolution reaction. Under visible light irradiation, the nitrogen‐doped carbon dots (NCdots) transfer the photoexcited electrons to the catalyst, producing an activity of 358 μmol gNCdot−1 h−1 (TONCo=570) for CoTSC−N(CH3)2CN after 24 h of irradiation. These types of molecular catalysts display great activity and stability in combination with the easily synthesized and modified carbon dot materials.
Chiral Substitution on Spaced Cations Lead to Improved Properties and Reversible Phase Transition, Broadband Emission in Parent Compound (3APr)PbBr4
Authors: Wan Ming‐Yang , Tang Yun‐Zhi , Tan Yu‐Hui , Li Yi‐Luo , Wang Fang‐Xin , Liao Juan , Wang Li‐Juan
Published: August 2023

Hybrid organic‐inorganic perovskites (HOIP) due to their excellent optoelectronic properties and flexible structure have attracted enthusiastic interest. In particular, introducing chirality is a method to enhance compound performance. Herein, we report a multifunctional compound: (3APr)PbBr4 (1) (3APr=3‐Pyrrolidinamine) and corresponding enantiomer R and S‐(3APr)PbBr4 (R/S‐2). Compound 1 show reversible solid‐state phase transition, step‐like dielectric anomaly and broadband yellow emission under uv light excitation. Accompany with phase transition, structure dimension transition from 2D to 1D without space group change. Through introduce chirality, the R/S‐2 display mirror image 1D structural relationship, increased quantum yield from 3.43 % (1) to 13.65 % (R/S‐2) and exhibits corresponding CD signals. Then combine to first‐principles analysis, it was found that fluorescence is attributed to the formation of instantaneous defects during excitation, leading to the formation of self‐trapped excitons (STEs). This finding will further promote the development of multifunctional compound and the study of chiral substitution enhance compound properties.
Movements and central positive complexes during an ECT‐induced seizure: A video‐EEG case
Authors: Nayak Chetan Sateesh , Kafashan Mohammad Mehdi , Nascimento Fábio A. , Farber Nuri B. , Palanca Ben Julian A. , Hogan R. Edward
Published: August 2023

Content available: Video.
Neuropsychiatric comorbidities and cognition in epilepsy with eyelid myoclonia: A retrospective pediatric case series
Authors: Ballarà Petitbò Maria , González Alguacil Elena , Gutiérrez Delicado Eva , Ortiz Cabrera Nelmar Valentina , Duat Rodríguez Anna , García Peñas Juan José , Soto Insuga Victor
Published: August 2023

Objective

Epilepsy with eyelid myoclonia (EEM) is a rare epileptic syndrome classified within the Genetic Generalized Epilepsies of childhood. It is characterized by a high drug resistance, and little is known about prognostic factors and neurodevelopmental comorbidities. The aim of this study was to describe the clinical features, cognitive profile, and prognostic factors in a series of children with EEM.

Methods

This is a retrospective observational study of patients diagnosed with EEM from 2012 to 2022 in a tertiary pediatric hospital.

Results

Seventeen patients were analyzed (mean age at symptom onset 5.8 years). Neuropsychiatric comorbidities were present in 76.4% (attention deficit hyperactivity disorder 58.8%, behavioral disorder 11.8%, autism spectrum disorder 11.8%, and psychotic outbreaks 11.8%). Neurocognitive assessment was performed in 75%, revealing cognitive impairment in 66.6% (62.5% with borderline intellectual function and 37.5% with ‐IQ <70‐), with predominant difficulties in executive functions, comprehensive language, and motor skills. Cognitive deterioration was observed in one patient in parallel onset with psychotic symptoms. High refractoriness to antiseizure medication (ASM) was observed, with only 23.5% of the patients being seizure‐free after a mean follow‐up of 7 years. The most effective ASM was valproic acid, and two of them received ketogenic diet with good response. Regarding prognostic factors, psychotic symptoms were associated with a greater number of antiseizure medication (p < .05) implying a more drug‐resistant epilepsy.

Significance

In our study, we found a high rate of cognitive and psychiatric comorbidities and high refractoriness. These data support the concept of EEM as an intermediate entity between idiopathic generalized epilepsy and epileptic and/or neurodevelopmental encephalopathy. Making a proper diagnosis and management of these comorbidities is necessary to improve prognosis and quality of life in EEM.
FTO‐mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR‐1343‐3p
Authors: Lin Wei , Mo Cai‐Qin , Kong Ling‐Jun , Chen Ling , Wu Kun‐Lin , Wu Xian
Published: August 2023

This study was to explore the regulatory effect of long non‐coding RNA LINC01559 on Docetaxel resistance in breast carcinoma (BCa) and its underlying mechanism. In the present study, we found that LINC01559 expression was elevated and LINC01559 overexpression facilitated docetaxel resistance in BCa cells. Moreover, it was revealed that the upregulation of LINC01559 in BCa cells was induced by FTO‐mediated demethylation in an m6A‐YTHDF2‐dependent manner. Additionally, Dual‐luciferase reporter assay confirmed the binding ability between LINC01559 and miR‐1343‐3p, and Pearson correlation analysis showed a negative correlation between them. Particularly, miR‐1343‐3p inhibition partly abolished the suppression on docetaxel resistance in BCa cells caused by LINC01559 knockdown. To sum up, FTO‐mediated epigenetic upregulation of LINC01559 promoted cell resistance to Docetaxel in BCa by negatively regulating miR‐1343‐3p.
Erratic birational behavior of mappings in positive characteristic
Authors: Cutkosky Steven Dale
Published: August 2023

Birational properties of generically finite morphisms of algebraic varieties can be understood locally by a valuation of the function field of X. In finite extensions of algebraic local rings in characteristic zero algebraic function fields which are dominated by a valuation, there are nice monomial forms of the mapping after blowing up enough, which reflect classical invariants of the valuation. Further, these forms are stable upon suitable further blowing up. In positive characteristic algebraic function fields, it is not always possible to find a monomial form after blowing up along a valuation, even in dimension two. In dimension two and positive characteristic, after enough blowing up, there are stable forms of the mapping which hold upon suitable sequences of blowing up. We give examples showing that even within these stable forms, the forms can vary dramatically (erratically) upon further blowing up. We construct these examples in defect Artin–Schreier extensions which can have any prescribed distance.
Visualizing Penetration of Fluorescent Dye through Polymer Coatings
Authors: Chaudhuri Krishnaroop , Medhi Riddhiman , Zhang Zhenglin , Cai Zhuoyun , Ober Christopher K. , Pham Jonathan T.
Published: August 2023

Understanding how small molecules penetrate and contaminate polymer films is of vital importance for developing protective coatings for a wide range of applications. To this end, rhodamine B fluorescent dye is visualized diffusing through polystyrene‐polydimethylsiloxane block copolymer (BCP) coatings using confocal microscopy. The intensity of dye inside the coatings grows and decays non‐monotonically, which is likely due to a combination of dye molecule transport occurring concurrently in different directions. An empirical fitting equation allows for comparing the contamination rates between copolymers, demonstrating that dye penetration is related to the chemical makeup and configuration of the BCPs. This work shows that confocal microscopy can be a useful tool to visualize the transport of a fluorophore in space and time through a coating.