bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Renewable Sources of Energy on Bid Modeling Strategy in an Emerging Electricity Market Using Oppositional Gravitational Search Algorithm
Authors: Singh Satyendra , Fozdar Manoj , Malik Hasmat , Khan Irfan Ahmad , Al Otaibi Sattam , Albogamy Fahad R.
Published: September 2021

Power suppliers in a dynamic power market can achieve full benefit by introducing a bidding strategy mechanism. In the power sector, renewable resources have significant gradual usage and their effect on the production of detailed bidding approaches is becoming further complicated in the industry. Due to the irregular nature of these renewable resources and because they are subject to several fluctuations, there is an inherent issue with generating electricity. Taking these considerations into account, attempts have been made to create a model of bidding strategy to optimize the benefit of the electricity producers using the oppositional gravitational search algorithm. The Weibull and Beta distribution functions are utilized to describe the stochastic characteristics of the wind-speed profile and solar-irradiation, respectively. For the IEEE-30 and IEEE-57 frameworks, the suggested method is being checked and explained. In comparison to other optimization approaches, the results of this approach were taken into account, and it was discovered that it outperformed other techniques in addressing bid difficulties. In addition, it is worth noting that the impact of renewable energy on the bidding strategy lowered market clearing and thermal power generating costs, and encouraged renewable influenced producers to put forward the excess electricity into the real-time market.
Evaluation of Air Quality Index by Spatial Analysis Depending on Vehicle Traffic during the COVID-19 Outbreak in Turkey
Authors: Alemdar Kadir Diler , Kaya Ömer , Canale Antonino , Çodur Muhammed Yasin , Campisi Tiziana
Published: September 2021

As in other countries of the world, the Turkish government is implementing many preventive partial and total lockdown practices against the virus’s infectious effect. When the first virus case has been detected, the public authorities have taken some restriction to reduce people and traffic mobility, which has also turned into some positive affect in air quality. To this end, the paper aims to examine how this pandemic affects traffic mobility and air quality in Istanbul. The pandemic does not only have a human health impact. This study also investigates the social and environmental effects. In our analysis, we observe, visualize, compare and discuss the impact of the post- and pre-lockdown on Istanbul’s traffic mobility and air quality. To do so, a geographic information system (GIS)-based approach is proposed. Various spatial analyses are performed in GIS with the statistical data used; thus, the environmental effects of the pandemic can be better observed. We test the hypothesis that this has reduced traffic mobility and improved air quality using traffic density cluster set and air monitoring stations (five air pollutant parameters) data for five months. The results shows that there are positive changes in terms of both traffic mobility and air quality, especially in April–May. PM10, SO2, CO, NO2 and NOx parameter values improved by 21.21%, 16.55%, 18.82%, 28.62% and 39.99%, respectively. In addition, there was a 7% increase in the average traffic speed. In order for the changes to be permanent, it is recommended to integrate e-mobility and sharing systems into the current transportation network.
Experimental Investigation of Frost Formation Influence on an Air Source Heat Pump Evaporator
Authors: Kropas Tomas , Streckienė Giedrė , Bielskus Juozas
Published: September 2021

The application of heat pumps in the heating systems of buildings in the cold or transitional season is becoming an increasingly common practice not only in Lithuania but in other countries as well. Due to the growing popularity of air-to-air or air-to-water heat pumps in the building sector, the problem of the evaporator heat exchanger freezing is also becoming more and more relevant. As the outdoor temperature drops, so does the heat pump’s coefficient of performance (COP) for heating. The freezing of the evaporator surface increases the energy consumption of the system, has a negative effect on heat exchange, distorts the normal operating cycle of the heat pump and the energy is wasted for defrosting processes. This article describes the experimental investigation of an air-to-water heat pump, presents the results obtained during the experiments and their interfaces. The experiments were carried out during the transitional/cold season. It was found that frost formation on the evaporator started when the outdoor temperature was <3.5 °C and the relative humidity reached 88%. The defrosting cycle took an average of 5 min. The impact of the evaporator freezing on the operation and COP of the heat pump was assessed.
Palladium-Functionalized Graphene for Hydrogen Sensing Performance: Theoretical Studies
Authors: Kishnani Vinay , Yadav Anshul , Mondal Kunal , Gupta Ankur
Published: September 2021

The adsorption characteristics of H2 molecules on the surface of Pd-doped and Pd-decorated graphene (G) have been investigated using density functional theory (DFT) calculations to explore the sensing capabilities of Pd-doped/decorated graphene. In this analysis, electrostatic potential, atomic charge distribution, 2D and 3D electron density contouring, and electron localization function projection, were investigated. Studies have demonstrated the sensing potential of both Pd-doped and Pd-decorated graphene to H2 molecules and have found that the gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), i.e., the HOMO-LUMO gap (HLG), decreases to 0.488 eV and 0.477eV for Pd-doped and Pd-decorated graphene, respectively. When H2 is adsorbed on these structures, electrical conductivity increases for both conditions. Furthermore, chemical activity and electrical conductivity are higher for Pd-decorated G than Pd-doped G, whereas the charge transfer of Pd-doped graphene is far better than that of Pd-decorated graphene. Also, studies have shown that the adsorption energy of Pd-doped graphene (−4.3 eV) is lower than that of Pd-decorated graphene (−0.44 eV); a finding attributable to the fact that the recovery time for Pd-decorated graphene is lower compared to Pd-doped graphene. Therefore, the present analysis confirms that Pd-decorated graphene has a better H2 gas sensing platform than Pd-doped graphene and, as such, may assist the development of nanosensors in the future.
Analysis of Influencing Factors of Carbon Emissions in China’s Logistics Industry: A GDIM-Based Indicator Decomposition
Authors: Zhang Changyou , Zhang Wenyu , Luo Weina , Gao Xue , Zhang Bingchen
Published: September 2021

Due to increased global carbon dioxide emissions, the greenhouse effect is being aggravated, which has attracted wide attention. China is committed to promoting the low-carbon development of all industries. This paper analyzed the influencing factors of carbon emissions in the Chinese logistics industry, so as to identify the key factors that influence carbon emissions. Based on the carbon emission data of China’s logistics industry in 2000–2019, this paper applied the carbon emission coefficients issued by the Intergovernmental Panel on Climate Change. For the first time, the Generalized Divisia Index Method was used to analyze the degree of influence of the factors on carbon emissions. This method considered more variables and their relationships. The results showed that (1) the carbon emissions of the logistics industry were increased by 3.22 times from 2000 to 2018, and showed negative growth for the first time in 2019; (2) the added value of the logistics industry is the most important factor in increasing carbon emissions (with a contribution ratio of 65.45%), energy consumption and practical population size are the main factors in carbon emissions. The promotion of this industry is subjected to decreased per capita carbon emissions, which have a large impact on total carbon emissions; (3) the intensity of carbon output is the most important factor in the reduction of carbon emissions (with a contribution ratio of −29.1%), where the energy carbon intensity and per capita added value are the main influencing factors with regard to the reduction of carbon emissions, while energy intensity has a negative inhibitory effect on carbon emissions, and (4) the influencing factors have negative effects on the cumulative inhibition of carbon emissions in the logistics industry, to an extent that is far less than the integral promotion of carbon emissions. Finally, according to the research conclusions of this paper, it is feasible to make recommendations for the carbon reduction of the logistics industry.
COVID-19 Outbreak Management and Vaccination Strategy in The United States of America
Authors: Amara Sara Aicha , Díaz Estefany Daniella , Menon Lakshmi Krishna , Singh Priyanka , Rozanova Liudmila , Flahault Antoine
Published: September 2021

Four months after the first case of COVID-19 was reported in the United States, the SARS-CoV-2 virus had spread to more than 90% of all counties. Although the transmission of the virus can be grossly mitigated through non-pharmaceutical interventions and public health measures, risks of future outbreaks, emergence of more infectious variants, and disruptions to socio-economic life will probably remain until effective vaccines are administered to large portions of the global population. An exceptional collaboration between governments and the scientific community has led to the authorization of eight vaccines globally for full use, four of which were funded and developed in the United States. In this paper, we contextualize epidemiological, political, and economic impacts of the COVID-19 vaccination strategy in the United States of America between 20 January 2020, to 5 May 2021, with a key focus on vaccine hesitancy and public-private partnerships.
Effects of Marketing Ages on the Physicochemical Properties and Sensory Aspects of Cured Broiler Chicken Breast Meat
Authors: Park Sin-Young , Kim Hack-Youn
Published: September 2021

This research evaluated the properties of cured chicken breasts of broiler chicken with different marketing ages (28, 30, 32, and 34 day). The water contents in the proximate compositions of the samples tended to decrease with increasing marketing age, while the protein content increased. The samples’ uncooked and cooked pH values, WHC, and cooking yield increased with increasing marketing age; however, the WHC and cooking yield were not significantly different between the 32 and 34 day samples (p > 0.05). In the case of the color, the 34 day samples were significantly lower in terms of lightness, but significantly higher in redness and yellowness compared to the other samples (p < 0.05). Although the shear forces of the 28–32 day samples were not significantly different (p > 0.05), those of the 28 and 30 day samples were significantly lower than those of the 34 day sample (p < 0.05). Furthermore, the aromatic profile (determined by principal component analysis) of the 34 day sample differed from that of the 28–32 day samples. Flavor evaluation of the cooked 30 and 32 day samples showed significant differences compared to the 28 and 34 day samples (p < 0.05), and the texture evaluation showed that the 34 day sample obtained a significantly lower score than the 28 day sample (p < 0.05). Overall, these results suggest that the current broiler marketing age of 32 day results in suitable quality properties for broiler cured chicken breast.
The Effect Ultrasound and Surfactants on Nanobubbles Efficacy against Listeria innocua and Escherichia coli O157:H7, in Cell Suspension and on Fresh Produce Surfaces
Authors: Rafeeq Shamil , Ovissipour Reza
Published: September 2021

Removing foodborne pathogens from food surfaces and inactivating them in wash water are critical steps for reducing the number of foodborne illnesses. In this study we evaluated the impact of surfactants on enhancing nanobubbles’ efficacy on Escherichia coli O157:H7, and Listeria innocua removal from spinach leaves. We evaluated the synergistic impact of nanobubbles and ultrasound on these two pathogens inactivation in the cell suspension. The results indicated that nanobubbles or ultrasound alone could not significantly reduce bacteria in cell suspension after 15 min. However, a combination of nanobubbles and ultrasonication caused more than 6 log cfu/mL reduction after 15 min, and 7 log cfu/mL reduction after 10 min of L. innocua and E. coli, respectively. Nanobubbles also enhanced bacterial removal from spinach surface in combination with ultrasonication. Nanobubbles with ultrasound removed more than 2 and 4 log cfu/cm2 of L. innocua and E. coli, respectively, while ultrasound alone caused 0.5 and 1 log cfu/cm2 of L. innocua and E. coli reduction, respectively. No reduction was observed in the solutions with PBS and nanobubbles. Adding food-grade surfactants (0.1% Sodium dodecyl sulfate-SDS, and 0.1% Tween 20), did not significantly enhance nanobubbles efficacy on bacterial removal from spinach surface.
Deep Learning Architectures for Skateboarder–Pedestrian Surrogate Safety Measures
Authors: Shourov Chowdhury Erfan , Sarkar Mahasweta , Jahangiri Arash , Paolini Christopher
Published: September 2021

Skateboarding as a method of transportation has become prevalent, which has increased the occurrence and likelihood of pedestrian–skateboarder collisions and near-collision scenarios in shared-use roadway areas. Collisions between pedestrians and skateboarders can result in significant injury. New approaches are needed to evaluate shared-use areas prone to hazardous pedestrian–skateboarder interactions, and perform real-time, in situ (e.g., on-device) predictions of pedestrian–skateboarder collisions as road conditions vary due to changes in land usage and construction. A mechanism called the Surrogate Safety Measures for skateboarder–pedestrian interaction can be computed to evaluate high-risk conditions on roads and sidewalks using deep learning object detection models. In this paper, we present the first ever skateboarder–pedestrian safety study leveraging deep learning architectures. We view and analyze state of the art deep learning architectures, namely the Faster R-CNN and two variants of the Single Shot Multi-box Detector (SSD) model to select the correct model that best suits two different tasks: automated calculation of Post Encroachment Time (PET) and finding hazardous conflict zones in real-time. We also contribute a new annotated data set that contains skateboarder–pedestrian interactions that has been collected for this study. Both our selected models can detect and classify pedestrians and skateboarders correctly and efficiently. However, due to differences in their architectures and based on the advantages and disadvantages of each model, both models were individually used to perform two different set of tasks. Due to improved accuracy, the Faster R-CNN model was used to automate the calculation of post encroachment time, whereas to determine hazardous regions in real-time, due to its extremely fast inference rate, the Single Shot Multibox MobileNet V1 model was used. An outcome of this work is a model that can be deployed on low-cost, small-footprint mobile and IoT devices at traffic intersections with existing cameras to perform on-device inferencing for in situ Surrogate Safety Measurement (SSM), such as Time-To-Collision (TTC) and Post Encroachment Time (PET). SSM values that exceed a hazard threshold can be published to an Message Queuing Telemetry Transport (MQTT) broker, where messages are received by an intersection traffic signal controller for real-time signal adjustment, thus contributing to state-of-the-art vehicle and pedestrian safety at hazard-prone intersections.
The Phenotypic Spectrum of Patients with PHARC Syndrome Due to Variants in ABHD12: An Ophthalmic Perspective
Authors: Nguyen Xuan-Thanh-An , Almushattat Hind , Strubbe Ine , Georgiou Michalis , Li Catherina H. Z. , van Schooneveld Mary J. , Joniau Inge , De Baere Elfride , Florijn Ralph J. , Bergen Arthur A. , Hoyng Carel B. , Michaelides Michel , Leroy Bart P. , Boon Camiel J. F.
Published: September 2021

This study investigated the phenotypic spectrum of PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa and early-onset cataract) syndrome caused by biallelic variants in the ABHD12 gene. A total of 15 patients from 12 different families were included, with a mean age of 36.7 years (standard deviation [SD] ± 11.0; range from 17.5 to 53.9) at the most recent examination. The presence and onset of neurological, audiological and ophthalmic symptoms were variable, with no evident order of symptom appearance. The mean best-corrected visual acuity was 1.1 logMAR (SD ± 0.9; range from 0.1 to 2.8; equivalent to 20/250 Snellen) and showed a trend of progressive decline. Different types of cataract were observed in 13 out of 15 patients (87%), which also included congenital forms of cataract. Fundus examination revealed macular involvement in all patients, ranging from alterations of the retinal pigment epithelium to macular atrophy. Intraretinal spicular hyperpigmentation was observed in 7 out of 15 patients (47%). From an ophthalmic perspective, clinical manifestations in patients with PHARC demonstrate variability with regard to their onset and severity. Given the variable nature of PHARC, an early multidisciplinary assessment is recommended to assess disease severity.
A Rare Case of Brachyolmia with Amelogenesis Imperfecta Caused by a New Pathogenic Splicing Variant in LTBP3
Authors: Flex Elisabetta , Imperatore Valentina , Carpentieri Giovanna , Bruselles Alessandro , Ciolfi Andrea , Pizzi Simone , Tedesco Maria Giovanna , Rogaia Daniela , Mencarelli Amedea , Di Cara Giuseppe , Verrotti Alberto , Troiani Stefania , Merla Giuseppe , Tartaglia Marco , Prontera Paolo
Published: September 2021

In recent years, a rare form of autosomal recessive brachyolmia associated with amelogenesis imperfecta (AI) has been described as a novel nosologic entity. This disorder is characterized by skeletal dysplasia (e.g., platyspondyly, short trunk, scoliosis, broad ilia, elongated femoral necks with coxa valga) and severe enamel and dental anomalies. Pathogenic variants in the latent transforming growth factor-β binding protein 3 (LTBP3) gene have been found implicated in the pathogenesis of this disorder. So far, biallelic pathogenic LTBP3 variants have been identified in less than 10 families. We here report a young boy born from consanguineous parents with a complex phenotype including skeletal dysplasia associated with aortic stenosis, hypertrophic cardiomyopathy, hypodontia and amelogenesis imperfecta caused by a previously unreported homozygous LTBP3 splice site variant. We also compare the genotypes and phenotypes of patients reported to date. This work provides further evidence that brachyolmia with amelogenesis imperfecta is a distinct nosologic entity and that variations in LTBP3 are involved in its pathogenesis.
Marine Monitoring for Offshore Geological Carbon Storage—A Review of Strategies, Technologies and Trends
Authors: Blomberg Ann E. A. , Waarum Ivar-Kristian , Totland Christian , Eek Espen
Published: September 2021

Carbon capture and storage (CCS) could significantly contribute to reducing greenhouse gas emissions and reaching international climate goals. In this process, CO2 is captured and injected into geological formations for permanent storage. The injected plume and its migration within the reservoir is carefully monitored, using geophysical methods. While it is considered unlikely that the injected CO2 should escape the reservoir and reach the marine environment, marine monitoring is required to verify that there are no indications of leakage, and to detect and quantify leakage if it should occur. Marine monitoring is challenging because of the considerable area to be covered, the limited spatial and temporal extent of a potential leakage event, and the considerable natural variability in the marine environment. In this review, we summarize marine monitoring strategies developed to ensure adequate monitoring of the marine environment without introducing prohibitive costs. We also provide an overview of the many different technologies applicable to different aspects of marine monitoring of geologically stored carbon. Finally, we identify remaining knowledge gaps and indicate expected directions for future research.
Influence of Sediment Cycling on the Rare-Earth Element Geochemistry of Fluvial Deposits (Caculuvar–Mucope, Cunene River Basin, Angola)
Authors: Cruz Armanda , Dinis Pedro A. , Gomes Alberto , Leite Paula
Published: September 2021

The rare-earth element (REE) geochemistry of sedimentary deposits has been used in provenance investigations despite the transformation that this group of elements may suffer during a depositional cycle. In the present investigation, we used the geochemistry and XRD mineralogy of a set of sand and mud fluvial deposits to evaluate the ability of REE parameters in provenance tracing, and the changes in REE geochemistry associated with weathering and sorting. The analyzed deposits were generated in a subtropical drainage basin where mafic and felsic units are evenly represented, and these crystalline rocks are covered by sedimentary successions in a wide portion of the basin. A few element ratios appear to hold robust information about primary sources (Eu/Y, Eu/Eu*, LaN/YbN, LaN/SmN, and GdN/YbN), and the provenance signal is best preserved in sand than in mud deposits. Sediment cycles, however, change the REE geochemistry, affecting mud and sand deposits differently. They are responsible for significant REE depletion through quartz dilution in sands and may promote discernible changes in REE patterns in muds (e.g., increase in Ce content and some light REE depletion relative to heavy REE).
Longitudinal Relationships between Nomophobia, Addictive Use of Social Media, and Insomnia in Adolescents
Authors: Lin Chung-Ying , Potenza Marc N. , Ulander Martin , Broström Anders , Ohayon Maurice M. , Chattu Vijay Kumar , Pakpour Amir H.
Published: September 2021

(1) Background: Temporal relationships between nomophobia (anxiety related to ‘no mobile phone phobia’), addictive use of social media, and insomnia are understudied. The present study aimed to use a longitudinal design to investigate temporal relationships between nomophobia, addictive use of social media, and insomnia among Iranian adolescents; (2) Methods: A total of 1098 adolescents (600 males; 54.6%; age range = 13 to 19) were recruited from 40 randomly selected classes in Qazvin, Iran. They completed baseline assessments. The same cohort was invited to complete three follow-up assessments one month apart. Among the 1098 adolescents, 812 (400 males; 49.3%; age range = 13 to 18) completed the baseline and three follow-up assessments. In each assessment, the participants completed three questionnaires, including the Nomophobia Questionnaire (NMP-Q), Bergen Social Media Addiction Scale (BSMAS), and Insomnia Severity Index (ISI); (3) Results: Multilevel linear mixed-effects regression analyses showed that participants demonstrated increased insomnia longitudinally over 3 months (B = 0.12 and 0.19; p = 0.003 and <0.001). Insomnia was associated with nomophobia (B = 0.20; p < 0.001) and addictive use of social media (B = 0.49; p < 0.001). Nomophobia and addictive use of social media interacted with time in associations with insomnia as demonstrated by significant interaction terms (B = 0.05; p < 0.001 for nomophobia; B = 0.13; p < 0.001 for addictive use of social media); (4) Conclusions: Both nomophobia and addictive use of social media are potential risk factors for adolescent insomnia. The temporal relationship between the three factors suggests that parents, policymakers, and healthcare providers may target reducing nomophobia and addictive use of social media to improve adolescents’ sleep.
Economic Valuation of Cultural Heritage Using the Travel Cost Method: The Historical Centre of the Municipality of Bucharest as a Case Study
Authors: Merciu Florentina-Cristina , Petrişor Alexandru-Ionuţ , Merciu George-Laurenţiu
Published: September 2021

Because heritage buildings represent a special category of goods due to characteristics such as uniqueness and irreversibility, they are associated with multiple possibilities of use. This article aims to present a complex analysis of the values associated with using heritage buildings in the historical center of Bucharest and their correlation with corresponding conservation measures using the travel cost method. The authors used two computation methods: the zonal travel cost and the individual travel cost methods. The application of Bravais–Pearson’s coefficient of linear correlation confirmed that the demand for a cultural heritage site is inversely related to the travel costs and distance. The results reflect that the demand also depends on other factors, such as the satisfaction level of the tourist experience and tourists’ income and motivations. The study highlights the usefulness of the travel cost method, which facilitates analyzing the relationship between the significant value of using historical monuments and the extremely important conservation process in the current context, marked by socioeconomic dynamics that determine many reuses of cultural heritage.
Inactivation of Salmonella enterica and Colletotrichum gloeosporioides on Whole Mangoes by Application of an Antimicrobial Coating Containing Oregano Essential Oil
Authors: Sánchez-Tamayo Martha , Ochoa-Martínez Claudia , Critzer Faith
Published: September 2021

Mangoes are susceptible to bacterial and fungal contamination during storage and transportation. This study investigated the effectiveness of pectin-based coatings containing oregano essential oil (OEO) to reduce Salmonella enterica contamination and decrease anthracnose disease on whole mangoes. A cocktail of five strains of Salmonella spp. and Colletotrichum gloeosporioides strains was spot inoculated in mangoes to verify the antibacterial and antifungal activity of OEO. The inoculated mangoes were coated with pectin-based coatings containing 0, 0.5, 0.7, and 0.9% OEO. Coated fruits were stored for 11 days at 25 °C and 90% of relative humidity. All treatments with OEO effectively inhibited the growth of Salmonella, causing a reduction of 2.5 CFU/cm2 compared to the control treatment (0% OEO). In addition, coatings effectively inhibited the growth of C. gloeosporioides on the mango surface after 9 days of storage to the same extent as the traditional Prochloraz fungicide. The efficacy of coatings treatments was between 88.06 and 96.68% compared to the control treatment. Sensory analysis showed that the OEO did not affect the quality attributes of coated mango. Results showed the potential benefits of applying the pectin-based coatings with OEO as an alternative to control S. enterica and C. gloeosporioides in whole mangoes.
Determination of the Elements Composition in Sempervivum tectorum L. from Bulgaria
Authors: Gentscheva Galia , Karadjova Irina , Radusheva Poli , Minkova Stefka , Nikolova Krastena , Sotirova Yoana , Yotkovska Ina , Andonova Velichka
Published: September 2021

Sempervivumtectorum L. is an evergreen plant with fleshy blue-green leaves forming a rosette. The plant is well-known in alternative medicine and has been used for thousands of years. Traditionally for medicinal purposes, the plant is used as a juice obtained by simple squeezing of fresh plants leaves. The total content of Ca, K, Na, Mg, Mn, Fe, Zn, Cu, Co, Al, V, Cr, Ni, Mo, Ba, Pb, Cd, Hg, As, and Tl in plant leaves of Sempervivum tectorum L. sampled from different habitats in Bulgaria was determined after microwave digestion and measurements by inductively coupled plasma mass spectrometry and flame atomic absorption spectrometry. Furthermore, the bioavailable fraction of essential elements Ca, Mg, Fe, Mn, and Zn was defined after extraction with a hydrochloric acid solution, mimicking stomach juice. The total element content showed a high bioavailability of essential human health elements, such as Ca, Mg, Fe, and Zn. Additionally, essential and toxic elements concentrations were quantified in a fresh juice, obtained by squeezing from plant leaves, as most frequently used in folk medicine. The results obtained demonstrated high concentrations of K, Mg, Ca, Zn, and Cu, which could be accepted as an explanation and a further confirmation of the anti-inflammatory action of this plant.
Introduction to the Special Issue “Socio-Hydrology: The New Paradigm in Resilient Water Management”
Authors: Younos Tamim , Parece Tammy E. , Lee Juneseok , Giovannettone Jason , Armel Alaina J.
Published: September 2021

Water is life! Ancient human communities were established in close proximity of natural water systems, i [...]
Clinical Presentations of Adolescents Aged 16–18 Years in the Adult Emergency Department
Authors: Brockhus Lara Aurora , Bärtsch Martina , Exadaktylos Aristomenis K. , Keitel Kristina , Klukowska-Rötzler Jolanta , Müller Martin
Published: September 2021

Background: In many large hospitals in Switzerland, adolescents 16 years and older are treated in adult emergency departments (ED). There have been few publications about this specific patient population, especially in Switzerland. This study aims to provide an overview of emergency presentations of adolescents between 16–18 years of age when compared to adults and focuses on their principle complaints. Methods: We conducted a single-centre, retrospective, cross-sectional study of all patients aged 16 years and older presenting to the adult ED at the University Hospital (Inselspital) in Bern, Switzerland, from 2013 to 2017. This analysis gives an overview of emergency presentations of adolescents between 16–18 years of age in this time period and compares their consultation characteristics to those of adult patients. Results: Data of a total of 203,817 patients who presented to our adult ED between 2013 and 2017 were analysed. Adolescents account for 2.5% of all emergency presentations. The number of ED presentations in the reviewed time period rose for adults (+2368, 95% CI: 1695, 3041, p = 0.002 consultations more per year; +25% comparing 2013 with 2017), while adolescent presentations did not significantly increase (p = 0.420). In comparison to adult patients, adolescents presented significantly more often during the night (39.1% vs. 31.5%, p < 0.001), as walk-ins (54.2% vs. 44.9%, p < 0.001), or with less highly acute complaints at triage (21% vs. 31%, p < 0.001). They were more likely to be discharged (70.8% vs. 52.2%, p < 0.001). We found a significant association between the two age groups and principle complaints. In comparison to adults, trauma and psychiatric problems were significantly more common among adolescents. Conclusions: Our data showed that complaints in adolescent patients under 18 years of age significantly differ from those in older patients. The artificial age cut-off therefore puts this vulnerable population at risk of receiving inadequate diagnostic testing and treatment adapted only for adults. Additional studies are needed on the reasons adolescents and young adults seek ED care, as this could lead to improvements in the care processes for this vulnerable population.
Interactions of Comorbidity and Five Simple Environmental Unhealthy Habits Concerning Physical and Mental Quality of Life in the Clinical Setting
Authors: Martínez-Urbistondo Diego , Suarez del Villar Rafael , Ramos-Lopez Omar , Fernández María Agud , Segovia Ramón Costa , Domínguez Andrea , de la Garza Rocío García , Gómez María López-Cano , Ramos Laura Prósper , San-Cristobal Rodrigo , Daimiel Lidia , Fernández Paula Villares , Martinez Jose Alfredo
Published: September 2021

The objective of this study was to examine the interactions between comorbidity and five lifestyle single habits concerning different subscales of quality of life (QoL). For the study, 302 patients were consecutively recruited at the internal medicine department of a tertiary teaching hospital. Lifestyle habits, comorbidities and QoL were recorded according to validated questionnaires. Five single unhealthy habits, such as tobacco consumption, dietary intake of ultra-processed pastries, raw nuts or carbonated drinks, sleep time and physical activity patterns were selected according to previously published data. The main outcomes of the study were the scores of the eight subscales of the SF-36 QoL survey. The aggregate of unhealthy habits showed statistically significant association to every category in the SF-36 questionnaire, both in the univariate and the multivariate analysis when adjusting by age, sex and comorbidity. An interaction was found between comorbidity and unhealthy habits in both physical and mental summaries of SF-36. In conclusion, the lifestyle assessment according to five unhealthy habits is associated with a worse QoL. The interaction between comorbidity and unhealthy habits is especially clear in diseased patients due to the interplay between illness and lifestyle in the prediction of QoL.
Body Mass and Income: Gender and Occupational Differences
Authors: Li Ping , Chen Xiaozhou , Yao Qi
Published: September 2021

This paper aims to examine the influence of body shape on income, which varies with gender and occupational structure in China. The data were obtained from the CGSS (Chinese General Social Survey) 2010–2017 Survey. The overall finding in this paper is that women and men face different body shape–income effects. For females, the obesity penalty is significant and is reinforced with increasing occupational rank. For men, the thinness penalty (or weight premium) is enhanced as the occupational class decreases. Body shape–income gaps are mainly caused by the occupational structure. Twenty-nine percent of the income gap between overweight and average weight women can be explained by the obesity penalty, 37% of the income gap between overweight and average weight men can be interpreted by the weight premium, and 11% of the gap between underweight and normal weight men can be explained by the thinness penalty. The findings also suggest that the effect of body shape on income consists of two pathways: body shape affects health capital and socialization, and therefore income. Healthy lifestyles and scientific employment concepts should be promoted, and measures to close the gender gap should be implemented.
Differences in Reward Sensitivity between High and Low Problematic Smartphone Use Adolescents: An ERP Study
Authors: Deng Xinmei , Gao Qiufeng , Hu Lijun , Zhang Lin , Li Yanzhen , Bu Xiangyu
Published: September 2021

Background: Problematic smartphone use is highly prevalent in adolescent populations compared to other age groups (e.g., adults and young children). Previous studies suggested that higher levels of reward sensitivity were associated with problematic smartphone use. Therefore, the current study investigated the neural processing of monetary and social reward and punishment feedbacks between high and low problematic smartphone use adolescents. Methods: 46 adolescents participated in the current study and they were categorized into two groups based on their level of problematic smartphone use: those who obtained low scores on the measure of problematic smartphone use were categorized as Low Problematic Smartphone Use (LPSU), and those who obtained high scores on the measure of problematic smartphone use were categorized as High Problematic Smartphone Use (HPSU). Electrocortical activities were recorded during the processing of monetary and social reward and punishment feedback. Results: (1) LPSUs evoked larger P3 in the social punishment condition than in the monetary punishment condition. HPSUs evoked larger P3 in the social reward condition than in the monetary condition. (2) The feedback-related negativity (FRN) amplitudes in the reward condition were significantly larger than those in the punishment condition. (3) HPSUs induced larger reward positivity in social feedback conditions than in monetary feedback conditions, while there were no significant differences between the two types of conditions in the LPSUs. Discussion: The results provide neural underpinning evidence that high sensitivity to social rewards may be related to problematic smartphone use in adolescence.
The Impact of COVID-19 Lockdown on Agility, Explosive Power, and Speed-Endurance Capacity in Youth Soccer Players
Authors: Pucsok József Márton , Kovács Miklós , Ráthonyi Gergely , Pocsai Balázs , Balogh László
Published: September 2021

Our goal was to assess agility, explosive power, and speed-endurance capacity by implementing noninvasive procedures and sport-specific tests. We hypothesized that agility, speed, explosive power, and speed-endurance capacity might be maintained or increased by an individualized home-based training program. Eleven adolescent athletes participated in our study; they executed three tests before the coronavirus outbreak and 13 weeks later, after the pandemic curfew. We used the SpeedCourt System to assess the sport-specific speed and agility parameters and monitor speed-endurance capacity. We conducted the first measurement at the end of the preparatory period, on 28 February 2020. The second session consisted of 4 weeks of regular training and 9 weeks of individual, home-based activities. Compared to the first (pre-pandemic) testing session, our participants demonstrated a significantly improved capacity of the lower limbs’ explosive strength after completing the home-based exercise routine, compared to the first (pre-pandemic) testing session. We found that agility, speed, and explosive power might be maintained at the same level under home-based conditions. We found that it was challenging for the participants to increase their “pre-pandemic” endurance capacities.
A Mechanistic Data-Driven Approach to Synthesize Human Mobility Considering the Spatial, Temporal, and Social Dimensions Together
Authors: Cornacchia Giuliano , Pappalardo Luca
Published: September 2021

Modelling human mobility is crucial in several areas, from urban planning to epidemic modelling, traffic forecasting, and what-if analysis. Existing generative models focus mainly on reproducing the spatial and temporal dimensions of human mobility, while the social aspect, though it influences human movements significantly, is often neglected. Those models that capture some social perspectives of human mobility utilize trivial and unrealistic spatial and temporal mechanisms. In this paper, we propose the Spatial, Temporal and Social Exploration and Preferential Return model (STS-EPR), which embeds mechanisms to capture the spatial, temporal, and social aspects together. We compare the trajectories produced by STS-EPR with respect to real-world trajectories and synthetic trajectories generated by two state-of-the-art generative models on a set of standard mobility measures. Our experiments conducted on an open dataset show that STS-EPR, overall, outperforms existing spatial-temporal or social models demonstrating the importance of modelling adequately the sociality to capture precisely all the other dimensions of human mobility. We further investigate the impact of the tile shape of the spatial tessellation on the performance of our model. STS-EPR, which is open-source and tested on open data, represents a step towards the design of a mechanistic data-driven model that captures all the aspects of human mobility comprehensively.
Dose- and Time-Dependent Effects of Oleate on Mitochondrial Fusion/Fission Proteins and Cell Viability in HepG2 Cells: Comparison with Palmitate Effects
Authors: de Sousa Isy F. , Migliaccio Vincenzo , Lepretti Marilena , Paolella Gaetana , Di Gregorio Ilaria , Caputo Ivana , Ribeiro Eliane Beraldi , Lionetti Lillà
Published: September 2021

Mitochondrial impairments in dynamic behavior (fusion/fission balance) associated with mitochondrial dysfunction play a key role in cell lipotoxicity and lipid-induced metabolic diseases. The present work aimed to evaluate dose- and time-dependent effects of the monounsaturated fatty acid oleate on mitochondrial fusion/fission proteins in comparison with the saturated fatty acid palmitate in hepatic cells. To this end, HepG-2 cells were treated with 0, 10 μM, 50 μM, 100 μM, 250 μM or 500 μM of either oleate or palmitate for 8 or 24 h. Cell viability and lipid accumulation were evaluated to assess lipotoxicity. Mitochondrial markers of fusion (mitofusin 2, MFN2) and fission (dynamin-related protein 1, DRP1) processes were evaluated by Western blot analysis. After 8 h, the highest dose of oleate induced a decrease in DRP1 content without changes in MFN2 content in association with cell viability maintenance, whereas palmitate induced a decrease in cell viability associated with a decrease mainly in MFN2 content. After 24 h, oleate induced MFN2 increase, whereas palmitate induced DRP1 increase associated with a higher decrease in cell viability with high doses compared to oleate. This finding could be useful to understand the role of mitochondria in the protective effects of oleate as a bioactive compound.
Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha
Authors: Yun Ba Da , Son Seung Wan , Choi Soo Young , Kuh Hyo Jeong , Oh Tae-Jin , Park Jong Kook
Published: September 2021

Hypoxia-inducible factor-1 alpha (HIF-1α) is overexpressed in cancer, leading to a poor prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in hypoxia and even in non-hypoxic conditions, affecting its progression and malignant characteristics by regulating the expression of the HIF-1α target genes that are involved in cell survival, angiogenesis, metabolism, therapeutic resistance, et cetera. Numerous studies have exhibited the anti-cancer effect of HIF-1α inhibition itself and the augmentation of anti-cancer treatment efficacy by interfering with HIF-1α-mediated signaling. The anti-cancer effect of plant-derived phytochemicals has been evaluated, and they have been found to possess significant therapeutic potentials against numerous cancer types. A better understanding of phytochemicals is indispensable for establishing advanced strategies for cancer therapy. This article reviews the anti-cancer effect of phytochemicals in connection with HIF-1α regulation.
Species-Specific Humoral Immune Responses in Sheep and Goats upon Small Ruminant Lentivirus Infections Inversely Correlate with Protection against Virus Replication and Pathological Lesions
Authors: Michiels Rodolphe , Roels Stefan , Vereecke Nick , Mathijs Elisabeth , Mostin Laurent , De Regge Nick
Published: September 2021

Maedi-Visna-like genotype A strains and Caprine arthritis encephaltis-like genotype B strains are small ruminant lentiviruses (SRLV) which, for incompletely understood reasons, appear to be more virulent in sheep and goats, respectively. A 9-month in vivo infection experiment using Belgian genotype A and B SRLV strains showed that almost all homologous (genotype A in sheep; genotype B in goats) and heterologous (genotype A in goats; genotype B in sheep) intratracheal inoculations resulted in productive infection. No differences in viremia and time to seroconversion were observed between homologous and heterologous infections. Higher viral loads and more severe lesions in the mammary gland and lung were however detected at 9 months post homologous compared to heterologous infection which coincided with strongly increased IFN-γ mRNA expression levels upon homologous infection. Pepscan analysis revealed a strong antibody response against immune-dominant regions of the capsid and surface proteins upon homologous infection, which was absent after heterologous infection. These results inversely correlated with protection against virus replication in target organs and observed histopathological lesions, and thus require an in-depth evaluation of a potential role of antibody dependent enhancement in SRLV infection. Finally, no horizontal intra- and cross-species SRLV transmission to contact animals was detected.
Topical Neck Cooling Prolongs Survival of Rats with Intra-Abdominal Feculent Sepsis by Activation of the Vagus Nerve
Authors: Zhang Aimee Y. , Marsh Katherine M. , Rastogi Radhika , Wu Di , Charles Eric J. , Kron Irving L. , Sawyer Robert G. , Yang Zequan
Published: September 2021

Global hypothermia prolongs survival in rats with intraabdominal feculent sepsis by inhibiting inflammatory responses. We hypothesized that topical neck cooling (TNC) has similar benefits. Septic shock was induced by cecal ligation and incision (CLI) in Sprague Dawley rats. Rats were randomized to sham laparotomy, control with CLI, CLI with TNC, or vagotomy at the gastroesophageal junction before CLI and TNC. Two more groups underwent peritoneal washout with and without TNC two hours after CLI. TNC significantly lowered neck skin temperature (16.7 ± 1.4 vs. 30.5 ± 0.6 °C, p < 0.05) while maintaining core body normothermia. TNC rats recovered from anesthesia 70 min earlier than the control (p < 0.05). Three hours following CLI, the control and vagotomy with TNC groups had significantly more splenic contraction, fewer circulating leukocytes and higher plasma IL-1β, IL-10 and TNF-α levels than TNC rats (p < 0.05). TNC prolonged survival duration after CLI by a median of four hours vs. control (p < 0.05), but no benefit was seen if vagotomy preceded TNC. Peritoneal washout alone increased survival by 3 h (9.2 (7.8–10.5) h). Survival duration increased dramatically with TNC preceding washout, to a 56% survival rate (>10 days). TNC significantly prolonged the survival of rats with severe intraabdominal sepsis by inhibiting systemic proinflammatory responses by activating vagal anti-inflammatory pathways.
Virtual Alanine Scan of the Main Protease Active Site in Severe Acute Respiratory Syndrome Coronavirus 2
Authors: Nakayoshi Tomoki , Kato Koichi , Kurimoto Eiji , Oda Akifumi
Published: September 2021

Recently, inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) have been proposed as potential therapeutic agents for COVID-19. Studying effects of amino acid mutations in the conformation of drug targets is necessary for anticipating drug resistance. In this study, with the structure of the SARS-CoV-2 Mpro complexed with a non-covalent inhibitor, we performed molecular dynamics (MD) simulations to determine the conformation of the complex when single amino acid residue in the active site is mutated. As a model of amino acid mutation, we constructed mutant proteins with one residue in the active site mutated to alanine. This method is called virtual alanine scan. The results of the MD simulations showed that the conformation and configuration of the ligand was changed for mutants H163A and E166A, although the structure of the whole protein and of the catalytic dyad did not change significantly, suggesting that mutations in His163 and Glu166 may be linked to drug resistance.