bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI MODEL PEMBELAJARAN BERBASIS INTUISI TERHADAP KREATIFITAS SISWA
Authors: Lestari Mulyaningrum
Published: August 2020

IMPLEMENTATION OF INTUITION BASED LEARNING MODEL ON STUDENT CREATIVITY. The purpose of this study was to determine the implementation of intuitive learning models for the creativity of class X students. The population of this study was class X students of SMAN 2 Sragen. The sample of this study was taken by cluster random sampling and selected class X. MIA 4 as an experimental class that uses expository learning, and class X.Mia 5 as a class that uses intuitive learning. Analysis of the data in this study were students in the class who used expository learning models, on average meeting the level of fluency thinking by 71.9% and still not meeting the level of other creative thinking. Then, students in the class who use the intuitive learning model obtained students who meet the level of thinking Flexibility and fluency thinking level of 82.14%. So it can be said that the creativity of students who get an intuitive-based learning model is better than students who get an expository learning model
LAWANG SEWU DALAM SUDUT PANDANG GEOMETRI
Authors: Oktaviani dkk Utari
Published: August 2020

 LAWANG SEWU IN GEOMETRY VIEW. Mathematics and culture are two things closely related. But sometimes mathematics is seen as something that is not connected to everyday life. Infactthe environment can be a source of mathematical problems in real life. The environment is one of culture, one of which includes historic buildings. Mathematics in culture is referred to by the term ethnomatematics. Lawang Sewu is one of the historical buildings located in the city of Semarang. The purpose of this research is to know the geometry structure of Lawang SEWU building. This building can be used as a research object with qualitative descriptive method, with data collection using direct observation on research object, interview with speaker, and using library study related to research This. Through research that the authors have done, it can be concluded that Lawang SEWU building has a geometry structure of space, namely cube, beam, Limas, and Octagonal prism.
MATHCPOLLY (MATEMATHIC CULTURE MONOPOLLY): MEDIAPEMBELAJARAN ETNOMATEMATIKA YANG TERINTEGRASISOSIALISASI SIKAP PRO ENVERONMENT BERBASIS AUGMENTED REALITY
Authors: Ghoyatul Muna Siti
Published: August 2020

MATHCPOLLY (MATEMATHIC CULTURE MONOPOLLY: MEDIA PEMBELAJARAN ETNOMATEMATIKA YANG TERINTEGRASI SOSIALISASI SIKAP PRO-ENVERONMENT BERBASIS AUGMENTED REALITY . The Industrial revolution in the world has undergone significant changes into the cyber or computer era so it is referred to as the 4.0 industry in which its development has expanded into various fields ranging from economic, social to educational. In addition, people in this era tend to be fast paced both in accessing information and other things.  So many educational media innovations from 4.0 to optimize the learning in the 4.0 industrial era, therefore we make MATHCPOLLY (Matemathic Culture Monopolly) is a game media monopoly of a collection of images and short messages Contain content related to ethnomatematics (mathematics on Culture) based on augmented. The Media is used for playing activities while studying ethnomatematics through RME. The research aims to introduce MATHCPOLLY as a simple media learning ethnomatematics, informing about the potential implementation of the MATHCPOLLY media. The research methods used are qualitative descriptive where data is obtained through open interviews, field studies, and literature studies. MATHCPOLLY Media is one of the right solutions as a socialization media of pro-environment as well as simple ethnomatematics learning.
KONTRIBUSI HABITS OF MIND TERHADAP KEMAMPUAN LITERASI MATEMATIS SISWA PADA MATERI GEOMETRI
Authors: Malasari Putri Nur
Published: August 2020

CONTRIBUTION OF HABITS OF MIND TOWARDS STUDENT MATHEMATICAL LITERACY ABILITY ON GEOMETRY. The relationship between habits of mind with mathematical literacy ability is the basis of this research. The purpose of this study was to determine the description of students 'habits of mind and the influence of habits of mind on students' mathematical literacy ability. This research is an ex post facto method. Through a purposive sampling technique selected 35 students of class VIII at one of junior high school in Bandung. Students work on geometry problems in the material to build flat side spaces and habits of mind scale. The results found that habits of mind had a positive contribution on students' mathematical literacy ability by 43.5%. It can be concluded to improve students' mathematical literacy ability by increasing habits of mind.
PENGEMBANGAN UKBM DIGITAL PADA MATERI PERTIDAKSAMAAN EKSPONEN
Authors: Hermawan Faried
Published: August 2020

DIGITAL UKBM DEVELOPMENT IN EXPONENT CONSIDER MATERIAL. The use of media and learning resources is part of the components that affect learning. Utilization and empowerment of UKBM to support learning is not only to improve the effectiveness and quality of learning, but more importantly is to increase the mastery of the material both teachers and students. One of the media that can be developed is an interactive learning module in the form of Digital UKBM. UKBM through multimedia can make the learning process more interesting, more interactive, able to convey historical messages through pictures and videos, encourage student learning through instrumentalia, be able to develop students' auditory senses or hearing, so that the material delivered is easier to understand. The purpose of this research is to design and build Digital UKBM on the material Inequality of Exponents in SMAN 2 Kudus and examine whether the application can facilitate the Teachers and Students in the learning process. This study uses a type of research development (Research and Development) with a model from Dick & Carey. This research was conducted on 3 Mathematics Teacher class X MIPA and students of Class X MIPA 1 and 2 as many as 72 people in SMA Negeri 2 Kudus 2018/2019 Academic Year for 2 months starting from the preparation stage until writing the report. The results of the study, 85.00% of respondents stated strongly agree that the application of digital UKBM in learning can be said to be easy to do and will help teachers and students in learning.
Respon Mahasiswa Terhadap Pemanfaatan Aplikasi Geogebra pada Materi Aplikasi Integral
Authors: Abadi Ma'ulfi Kharis
Published: August 2020

Di universitas, ada materi tentang aplikasi integral. Banyak dosen menggambar kurva secara manual. Gambar yang dibuat secara manual memiliki berbagai kelemahan seperti tidak sesuai dengan konsep dan pembuatannya lama. Untuk membuat kurva pada kuliah bisa menggunakan aplikasi geogebra. Geogebra dapat membuat titik, garis, dan kurva dengan cepat dan bahkan dapat menghitungnya. Penelitian ini mencari informasi tentang respons mahasiswa terhadap penggunaan geogebra. Penelitian ini dilakukan di sebuah universitas di kota Serang pada lima kelas. Data dikumpulkan menggunakan kuesioner yang dibagikan kepada mahasiswa. Respon mahasiswa terhadap penggunaan geogebra mendapatkan nilai positif.
НЕКОТОРЫЕ АСПЕКТЫ ПОВРЕЖДЕНИЯ ПЕЧЕНИ ПРИ ИНФЕКЦИИ, ВЫЗВАННОЙ SARS-CoV-2
Authors: Маннанова Ирина , Понежева Жанна , Макашова Вера , Омарова Хадижат , Рейзис Ара , Горелов Александр
Published: August 2020

РЕЗЮМЕ: обзорная статья посвящена анализу имеющихся данных о различных причинах и частоте поражения печени при новой коронавирусной инфекции COVID-19.

Большинство ученых выявили повышенный уровень печеночных ферментов (от 37% до 69%) при тяжелом течении инфекции. Причины поражения печени связывают с системным полиорганным поражением с высвобождением большого количества провоспалительных цитокинов, в частности, к массивному высвобождению интерлейкина 6, что обусловливает тяжелое течение инфекции SARS-CoV-2, наличием сопутствующей патологии печени, а также возможностью ее лекарственного повреждения от 4,2% до 45,4% в зависимости от препаратов (противовирусные, антибиотики и др.)
Inappropriate child feeding practice and primary health care as major correlates of stunting and underweight among infants and young children 6-23months of age in food insecure households of Amhara and Oromia Regions, Ethiopia. A community based cross sectional study
Authors: Wondimagegne Zelalem Tafese , Alemayehu Fekadu Reta , Adole Anchamo Anato , Yimam Kaleab Baye , Berhan Yifru , Stoecker Barbara J
Published: August 2020

The authors have withdrawn this preprint due to author disagreement.
Integrative transcriptome and proteome analyses provide new insights into different stages of Akebia trifoliata fruit cracking during ripening
Authors: Niu Juan , Shi Yaliang , Huang Kunyong , Zhong Yicheng , Chen Jing , Sun Zhimin , Luan Mingbao , Chen Jianhua
Published: August 2020

Background: Akebia trifoliata (Thunb.) Koid may have applications as a new source of biofuels owing to its high seed count, seed oil content, and in-field yields. However, the pericarp of A. trifoliata cracks longitudinally during fruit ripening, which increases the incidence of pests and diseases and can lead to fruit decay and deterioration, resulting in significant losses in yield. Few studies have evaluated the mechanisms underlying A. trifoliata fruit cracking. Results: In this study, by observing the cell wall structure of the pericarp, we found that the cell wall became thinner and looser and showed substantial breakdown in the pericarp of cracking fruit compared with that in non-cracking fruit. Moreover, integrative analyses of transcriptome and proteome profiles at different stages of fruit ripening demonstrated changes in the expression of various genes and proteins after cracking. Furthermore, the mRNA levels of 20 differentially expressed genes were analyzed, and parallel reaction monitoring analysis of 20 differentially expressed proteins involved in cell wall metabolism was conducted. Among the molecular targets, pectate lyases and pectinesterase, which are involved in pentose and glucuronate interconversion, and β-galactosidase 2, which is involved in galactose metabolism, were significantly upregulated in cracking fruits than in non-cracking fruits. This suggested that they might play crucial roles in A. trifoliata fruit cracking. Conclusions: Our findings provided new insights into potential genes influencing the fruit cracking trait in A. trifoliata and established a basis for further research on the breeding of cracking-resistant varieties to increase seed yields for biorefineries.
Influential factors of postoperative outcomes of symptomatic lateral discoid meniscus
Authors: Yang ShunJie , Ding Zhong-Jun , Li Jian , Xue Yang , Chen Gang
Published: August 2020

Background: Due to its abnormal morphology and ultrastructure, discoid lateral meniscus (DLM) is prone to tear and degeneration, leading to clinical symptoms. Arthroscopy is the main treatment for symptomatic DLM; however, postoperative outcomes vary widely due to the effects of diverse factors. This research aims to explore the factors influencing postoperative outcomes of symptomatic DLM. Methods: Patients with DLM who underwent arthroscopic surgery at our hospital from 9/2008 to 9/2015 were enrolled according to the inclusion and exclusion criteria. Fourteen variables, including sex, body mass index (BMI) and other variables, were chosen as factors for study. Knee function was assessed using the International Knee Documentation Committee (IKDC) score. Univariate analyses (Mann-Whitney U test or Kruskall-Wallis rank sum test) and multivariate analyses (ordinal logistic regression) were used to identify the factors that influenced postoperative outcomes. P<0.05 was considered statistically significant.Results: A total of 502 patients, including 353 females (70.3%) and 149 males (29.7%), were enrolled. The median IKDC score postoperatively (87.4; range, 41.4~97.7; IQR, 14.6) was higher than that preoperatively (57.6; range, 26.9~ 64.9; IQR, 9.7) (P<0.001). Male sex was predictive of a higher IKDC score (P=0.023, OR=1.702). Compared with BMI ≥25 kg/m2, <18.5 kg/m2 was associated with better IKDC score (P=0.026, OR=3.016). Contrasting with age of onset ≥45 years, ≤14 years (P<0.001, OR=20.780) and 14~25 years (P<0.001, OR=8.516) were associated with better IKDC score. In comparison with symptoms duration>24 months, IKDC scores for patients with symptoms duration ≤1 month (P=0.001, OR=3.511), 1 ~ 6 months (P < 0.001, OR = 3.463) and 6 ~ 24 months (P < 0.001, OR = 3.254) were significantly elevated. Compared to Outerbridge grade III ~ IV, no injury (P<0.001, OR=6.379) and grade I (P=0.01, OR=4.332) were associated with higher IKDC score.Conclusions: Arthroscopic treatment of symptomatic DLM is safe and effective, but its clinical efficacy is affected by many factors. Specifically, male sex, BMI < 18.5kg/m2, age of onset < 25 years (especially < 14 years) and symptoms duration < 24 months are conducive to good postoperative outcomes. However, combined articular cartilage injury (Outbridge grade≥2) reduces postoperative effect.
Continuous inflorescence removal changes parameters, lignin and saponin a content and alters the transcriptome of root of Bupleurum chinense DC
Authors: Wang Hui , Zhang Gaixia , Gao Zhihui , Sui Chun , Wei Jianhe
Published: August 2020

The authors have withdrawn this preprint due to the presence of errors
Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds
Authors: Xiong Ying , Hao Yan , Cheng Yalin , Fan Liqing , Song Gang , Li Dongming , Qu Yanhua , Lei Fumin
Published: August 2020

Background

Pectoralis phenotypic variation plays a fundamental role in locomotion and thermogenesis in highland birds. However, its regulatory and metabolic mechanisms remain enigmatic to date. Here, we integrated phenomic, transcriptomic and metabolomic approaches to determine muscle variation and its underpinning mechanisms across altitudinal songbirds.

Results

Phenomics revealed that all highland birds had considerable increases in muscle oxidative capacity, capillarity, and mitochondrial abundance. Correspondingly, transcriptomic analyses found that differentially expressed genes in modules associated with phenotypes enriched in blood vessel, muscle structure development, and mitochondrial organization. Despite similar traits and functional enrichments across highland birds, different mechanisms drove their occurrence in part for their own various evolutionary histories. Importantly, a metabolic feature shared by highland birds is the improvement in insulin sensitivity and glucose utilization through activating insulin signaling pathway, which is vital to increase muscle oxidative capacity and maintain metabolic homeostasis. Nevertheless, fatty acid biosynthesis and oxidation are enhanced in species with a long evolutionary history, also differing from ketone body metabolism in recently introduced colonizer.

Conclusions

Our study represents a vital contribution to reveal the regulatory and metabolic basis of pectoralis variation across altitudinal songbirds.
Evaluating a multidimensional strategy to improve the professional self-care of occupational therapists working with people with life limiting illness.
Authors: Apostol Courtney , Cranwell Kathryn , Hitch Danielle
Published: August 2020

Background: The term ‘’life limiting conditions’ refers to premature death following decline from chronic conditions, which is a common circumstance in which occupational therapists work with people at the end of life. The challenges for clinicians of working with these patients have long been recognised, and may have a significant impact on their professional self-care. This study aimed to evaluate a multidimensional workplace strategy to improve the professional self-care of occupational therapists working with people living with a life limiting condition.Methods: A pre and post mixed methods survey approach were utilised, with baseline data collection prior to the implementation of a multidimensional workplace strategy. The strategy included professional resilience education, targeted supervision prompts, changes to departmental culture and the promotion of self-care services across multiple organisational levels. Follow up data collection was undertaken after the strategy had been in place for two years. Quantitative data were analysed descriptively, while qualitative data were subjected to thematic analysis. Results: 103 occupational therapists responded (n=55 pre, n=48 post) across multiple service settings. Complex emotional responses and lived experiences were identified by participants working with patients with life limiting conditions, which were not influenced by the workplace strategy. Working with these patients was acknowledged to challenge the traditional focus of occupational therapy on rehabilitation and recovery. Participants were confident about their ability to access self-care support, and supervision emerged as a key medium. While the strategy increased the proportion of occupational therapists undertaking targeted training, around half identified ongoing unmet need around professional self-care with this patient group. Demographic factors (e.g. practice setting, years of experience) also had a significant impact on the experience and needs of participants. Conclusions: The multidimensional workplace strategy resulted in some improvements in professional self-care for occupational therapists, particularly around their use of supervision and awareness of available support resources. However, it did not impact upon their lived experience of working with people with life limiting conditions, and there remain significant gaps in our knowledge of support strategies for self-care of occupational therapist working with this patient group.
WITHDRAWN: Role of Organizations in Preparedness and Emergency Response to Flood Disaster in Bangladesh
Authors: Hossain Babul
Published: August 2020

The present study is to know the role of organizations and make an assessment on their assistance regarding preparedness and emergency response of flood disaster affected people. This study has used a mixed-method approach. Flood-affected people were the respondents to evaluate the organizational role. The study reveals that before the flood in 2017 to minimize the loss and damages, the GOs play a very effective role concerning the arrangement of preparatory meetings and preparing shelter centers, and NGOs play a very useful role in making arrangements for awareness-building training. During the emergency period, the GOs played a comparatively better role in providing CI sheets, agricultural assistance and cash money as relief for establishing housing facilities and emergency support. The NGOs played relatively a better role in providing food, water, clothes, medicine, etc. This study put forward complications such as limited sanctions, disruption of communication, lack of awareness of sufferers, and overlapping. The findings of this study would be a significant for the disaster policymakers, and civil societies.
Keywords: Organizations (GOs & NGOs); Flood Disaster; Preparedness; Emergency Response; Bangladesh
Applying 3D-Eco Routing Model to Reduce Environmental Footprint of Road Transports in Addis Ababa City
Authors: Busho Seifu Woldemichael , Alemayehu Daniel
Published: August 2020

BackgroundClimate change has emerged as a very important threat to economic development, atmosphere, and public health. One of the driving factors behind global climate change is road transportation. Therefore, the sector needs to take on the responsibility of addressing its negative impacts on the environment. This study seeks to find ways of mitigating the impacts of climate change. It pays particular attention to greenhouse gas emissions and other selected air pollutants based on anew navigation concept called eco-route, a3D Eco -Routing transportation planning method that can help reduce the environmental footprints of Road transports in Addis Ababacity for distribution vehicles. The model applied in this study considered the road gradient, varying velocity or speed of vehicles, and weight of vehicles to evaluate gradient effects on consumption of fuel, CO2 and also other air pollutants emission. The model is applied in three scenarios within different vehicle weight ranges and three different cases in Addis Ababa.ResultThe finds of the study imply the eco-routes emission reduction potential from fuel and CO2 in the tested scenarios is up to 39.81% while other air pollutants account for 25.65%.The results prove that Eco Routes have the ability of reducing Fuel consumption, CO2 and other air pollutant emission rate.ConclusionsEco routes have the potential to provide sustainable transportation opportunities for Addis Ababa city. This study recommends that eco-routes should be used instead of Shortest and Fastest routes where significant road gradients exist.
MiR-4792 regulates inflammatory responses in Cryptococcus neoformans infected microglia
Authors: Chen Jianghan , Yao Guotai , Wang Xiaoli , Hou Qing , Gao Rui , Wang Yilin , Teng Liang , Lin Wenting , Wang Yan , Wang Zhongzhi , Jin Yi
Published: August 2020

Background: Investigating the factors that influence inflammatory response of microglial cells is important to understand the pathogenesis of cryptococcal meningitis (CM). MicroRNA (miRNA) have been shown to play an important role in inducing host defenses and activating immune response in the process of microbial infection; however, the regulatory mechanisms of miRNAs in cryptococcal meningitis are poorly defined. In our previous analysis, we assessed the miRNA profiles of BV2 cells following Cryptococcus neoformans (C. neoformans) infection. In this study, we characterized the expression of miR-4792 in CM patients to further our understanding of the host response to pathogen infections. Results: miR-4792 was downregulated in BV2 cells infected with C. neoformans while its target gene EGFR was upregulated. Infected cells with up-regulated miR-4792 exhibited a trend towards decreased EGFR transcript expression, reduced MAPK signaling and a decreased secretion of inflammatory cytokines. Afterantifungal treatment in cryptococcal meningitis patients, the levels of miR-4792 in the CSF significantly increased, while the expression of EGFR significantly decreased. Conclusion: This study identified that miR-4792 and its target gene EGFR regulate the secretion of inflammatory cytokines in BV2 cells infected with C. neoformans. This furthers our knowledge of the inflammatoryresponses to fungal infections in the CNS.
The effectiveness of a web-based decision aid for patients with hip osteoarthritis: study protocol for a randomized controlled trial.
Authors: Perestelo-Perez Lilisbeth , Alvarez-Perez Yolanda , Rivero-Santana Amado , Ramos-García Vanesa , Duarte-Díaz Andrea , Torres-Castaño Alezandra , Toledo-Chávarri Ana , Herrera-Perez Mario , País-Brito Jose Luis , Castillo José Carlos del , Vázquez José Ramón , Orrego Carola , Serrano-Aguilar Pedro
Published: August 2020

Background: Osteoarthritis (OA) is a health condition sensitive to patient’s preferences and values regarding the benefits and risks of the different treatment options. In this sense, patient decision aids (PtDA) can play an important role in helping patients to incorporate their values, needs and preferences into the decision-making process, thus improving Person-Centred Care. Previous research has focused almost exclusively on knee OA, and therefore the aim of this study is to develop and evaluate the effectiveness of a PtDA for patients with hip OA.Methods: The general design consists of two phases: 1) design a web-based PtDA for patients with hip OA, following the recommended procedures: systematic review of safety/effectiveness of treatments, and an iterative process of development with the help of an Advisory Committee composed of health professionals and patients; 2) To evaluate the impact of the PtDA on hip OA patients’ decision-making process related with their treatment. For that aim, a multicenter randomized controlled trial will be carried out with 124 patients with hip OA in Tenerife (Spain) comparing intervention or usual care.Discussion: PtDAs have been recommended as a useful and effective resource for improving PCC in many health conditions. The intervention is intended to empower patients by fostering their active participation during the decision-making process about their treatment, and by ensuring they make informed decisions congruent with their values and preferences. This study will contribute to the scientific knowledge about effectiveness of PtDAs in hip OA, in order to improve the quality of health care offered to these patients.Trial registration: ClinicalTrials.gob (NCT04241978). Registered on 24 January 2020.
Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal stage
Authors: BOUSIGES Olivier , Philippi Nathalie , Lavaux Thomas , Perret-Liaudet Armand , Lachmann Ingolf , Schaeffer-Agalède Caroline , Anthony Pierre , Botzung Anne , Rauch Lucie , Jung Barbara , de Sousa Paulo Loureiro , Demuynck Catherine , Martin-Hunyadi Catherine , Cretin Benjamin , Blanc Frédéric
Published: August 2020

Background: Several studies have investigated the value of alpha-synuclein assay in the cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) patients in the differential diagnosis of these two pathologies. However, very few studies have focused on this assay in AD and DLB patients at the MCI stage.Methods: All patients were enrolled under a hospital clinical research protocol from the tertiary Memory Clinic (CM2R) of Alsace, France, by an experienced team of clinicians. A total of 166 patients were included in this study: 21 control subjects (CS), 51 patients with DLB at the prodromal stage (pro-DLB), 16 patients with DLB at the demented stage (DLB-d), 33 AD patients at the prodromal stage (pro-AD), 32 AD patients at the demented stage (AD-d) and 13 patients with mixed pathology (AD+DLB). CSF levels of total alpha-synuclein were assessed using a commercial enzyme-linked immunosorbent assay (ELISA) for alpha-synuclein (AJ Roboscreen). Alzheimer’s biomarkers (t-Tau, P-Tau, Aβ42 and Aβ40) were also measured.Results: The alpha-synuclein assays showed a significant difference between the AD and DLB groups. Total alpha-synuclein levels were significantly higher in AD patients than in DLB patients. However, the ROC curves show a moderate discriminating power between AD and DLB (AUC = 0.78) which does not improve the discriminating power of the combination of Alzheimer biomarkers (AUC = 0.95 with or without alpha-synuclein). Interestingly, the levels appeared to be altered from the prodromal stage in both AD and DLB.Conclusions: The modification of total alpha-synuclein levels in the CSF of patients occurs early, from the prodromal stage. The adding of alpha-synuclein total to the combination of Alzheimer’s biomarker does not improve the differential diagnosis between AD and DLB.Trial registration: ClinicalTrials.gov, (AlphaLewyMa, Identifier: NCT01876459)
Facile method for the selective recovery of Gd and Pr from LCD screen wastes using ultrasound-assisted leaching
Authors: Toache-Pérez Astrid D. , Bolarín-Miró Ana M. , Jesús Félix Sánchez-De , Lapidus Gretchen T.
Published: August 2020

Rare earth elements (REE) are essential for the production of technological devices. However, their high demand and low availability, together with an increase in electronic waste generation, compel the development of efficient, economic and green methods for recovering these elements from electronic waste. In this work, a facile method for selective recovering of REE from Liquid Crystal Display (LCD) screen wastes, employing ultrasound assisted leaching is presented. The screen wastes were milled and sieved to pass through a -325 mesh sieve (44 µm). The milled powder was subjected to ultrasound-assisted leaching in an aqueous medium, at room temperature (25 °C) and pH 6 for 60 min. Subsequently, a magnetic separation was applied to the leach residue. Inductively coupled plasma was employed to quantitatively analyze the composition of the LCD powders and determine the effectiveness of the extraction process. Scanning Electron Microscopy/Energy Dispersive X-Ray Spectroscopy allowed qualitative chemical analysis of the solid materials. The results show that the LCD screen wastes are formed, mainly, by amorphous oxides of Si, Fe, In, Sn and REE. The amount of Gadolinium (Gd) and Praseodymium (Pr) in the wastes were 93 and 24 mg kg-1, respectively, which justifies their recovery. X-ray diffraction analysis of the magnetic portion of the leached residue, confirmed the presence of an amorphous phase together with crystalline metallic iron alloy. The magnetic behavior, obtained by Vibration Sample Magnetometry, helped to understand the nature of the residues. The formation of this metallic alloy is attributed to the effect of high power ultrasonic during the leach. It was confirmed that the magnetic residue concentrates and recovers 87 wt% of Gd and 85 wt% of Pr contained in the original material. Therefore, ultrasound-assisted leaching is a selective and facile method for recovering Gd and Pr from waste LCD.
Effect of prophylactic anticoagulation on the incidence of venous thromboembolism in patients with testicular germ cell tumor.
Authors: Hapakova Nikola , Chovanec Michal , Rejlekova Katarina , Kalavska Katarina , Obertova Jana , Palacka Patrik , De Angelis Valentina , Sycova-Mila Zuzana , Mardiak Jozef , Mego Michal
Published: August 2020

Background

Testicular germ cell tumors (GCTs) are among the most common solid tumors in young males. With the availability of highly effective treatment, improving patients’ quality of life has gained more focus in recent years. Venous thromboembolism (VTE), commonly occurring in patients with GCT, is associated with increased morbidity and mortality. Prophylactic anticoagulation has been shown to decrease the risk of VTE in patients with malignancy. The aim of this retrospective study was to evaluate the effect of low-molecular-weight heparin (LMWH) prophylaxis on the incidence of VTE and outcome in patients with GCT treated with first-line chemotherapy.

Methods

Our study population included chemotherapy-naive patients with GCT treated with first-line chemotherapy at the National Cancer Institute, Bratislava, Slovakia, from January 2000 to December 2017. VTE was defined as any venous thrombosis or pulmonary embolism, confirmed by imaging, occurring during first-line chemotherapy. Patients diagnosed with VTE on initial staging exam were excluded from the study. No visceral thromboses were observed.

Results

Our cohort included 353 patients with GCT. LMWH prophylaxis was administered to 104 patients (29.5%), and 249 patients (70.5%) did not receive prophylaxis. We observed 14 (4.0%) VTE events. The difference in VTE incidence between patients with and without prophylaxis was not statistically significant (5.8% vs. 3.2% P = 0.37). We observed a trend toward longer overall survival in patients without prophylaxis (hazard ratio = 0.61, 95% confidence interval = 0.32-1.13, p = 0.08). Patients with extragonadal GCT receiving VTE prophylaxis had significantly shorter survival (hazard ratio = 0.29, 95% confidence interval = 0.08-1.12, P = 0.04). This effect was most likely driven by a higher incidence of treatment-related deaths in patients with extragonadal GCT receiving LMWH ( P = 0.06).

Conclusions

LMWH prophylaxis was not associated with decreased VTE incidence.Moreover, there was a higher incidence of treatment-related deaths in patients with extragonadal tumor location. LMWH prophylaxis during hospitalization should not be used routinely in patients with GCT receiving chemotherapy.
Evaluation of antiparasitic therapy directly administered for the control of canine echinococcosis in an endemic area of hydatidosis.
Authors: Montalvo Raul , Huiza Alaina , Clemente Johana , Castañeda Lorena , Ccente Yoli , Nuñez Mayori , Arteaga Lizet , Balbuena Lizzeth , Inga Cristhian
Published: August 2020

Background: Echinococcosis remains endemic despite attempts to reduce the prevalence of this disease. The dog faeces were analyzed by coproantigen using the immunoenzymatic technique for the diagnosis of echinococcosis before and after the direct and observed administration of praziquantel 5mg by kg orally in three doses every 30 days each cycle was 2 times at year for two consecutive years. The objective of the study was to evaluate the results of an intervention program based on antiparasitic therapy directly administered to the dogs for the control of Echinococcus in an endemic area of ​​ cystic echinococcosis (CE).Results: A total of 252 dogs entered the study, of them 119 (47%) dogs had positive results for Echinococcus at the beginning of the intervention. The adverse effects that occurred with the administration of prazicuantel were vomiting (13%), diarrhea (2.4%) and lethargy (2%); 229 dogs completed the 4 cycles of praziquantel treatment. The presence of a positive coproantigen was evident in 03 (1.3%) dogs at the end of the study.Conclusions: Antiparasitic chemotherapy administered directly to the dogs periodically managed to reduce the prevalence of canine echinococcosis.
Molecular-based cross-species evaluation of bovine coronavirus infection in cattle, sheep and goats in Ghana.
Authors: Burimuah Vitus , Sylverken Augustina , Owusu Michael , El-Duah Philip , Yeboah Richmond , Lamptey Jones , Frimpong Yaw Oppong , Agbenyega Olivia , Folitse Raphael , Emikpe Ben , Tasiame William , Owiredu Eddie-Williams , Oppong Samuel , Antwi Christopher , Adu-Sarkodie Yaw , Drosten Christian
Published: August 2020

Background: Apart from the huge worldwide economic losses often occasioned by bovine coronavirus (BCoV) to the livestock industry particularly cattle, continuous surveillance of the virus in cattle and small ruminants is essential in monitoring variations in the virus that could enhance host switching. In this study, we collected rectal swabs from a total of 1,498 cattle, sheep and goats. BCoV detection was based on reverse transcriptase polymerase chain reaction. Sanger sequencing of the partial RNA-dependent RNA polymerase (RdRp) region for postive samples were done and nucleotide sequences were compared with homologous sequences from the GenBank.Results: The study reports a BCoV prevalence of 0.3% consisting of 4 positive cases; 3 goats and 1 cattle. Less than 10% of all the animals sampled showed clinical signs such as diarrhea and respiratory distress except for high temperature which occurred in > 1000 of the animals. However, none of the 4 BCoV positive animals manifested any clinical signs of the infection at the time of sample collection. Bayesian majority-rule cladogram comparing partial and full length BCoV RNA-dependent RNA polymerase (RdRp) genes obtained in the study to data from the GenBank revealed that the sequences obtained from this study formed one large monophyletic group with those from different species and countries. The goat sequences were similar to each other and clustered within the same clade. No major variations were thus observed with our isolates and those from elsewhere.Conclusion: Given that Ghana predominantly practice the extensive and semi-intensive systems of animal rearing, our study highlights the potential for spillover of BCoV to small ruminants in settings with mixed husbandry and limited separation between species.
Microstructure and mechanical properties of 3D Cf/SiBCN composites fabricated by polymer infiltration and pyrolysis
Authors: Chen Bowen , Ding Qi , Ni De-Wei , Wang Hongda , Ding Yusheng , Zhang Xiangyu , Dong Shaoming
Published: August 2020

In this work, 3D C f /SiBCN composites were fabricated by polymer infiltration and pyrolysis (PIP) with poly(methylvinyl)borosilazane as SiBCN precursor. The 3D microstructure evolution process of the composites was investigated by an advanced x-ray computed tomography (XCT). The effect of dicumyl peroxide (DCP) initiator addition on the crosslinking process, microstructure evolution and mechanical properties of the composites were uncovered. With the addition of DCP initiator, the liquid precursor can cross-link to solid-state at 120 °C. Moreover, DCP addition decreases the release of small molecule gas during pyrolysis, leading to an improved ceramic yield 4.67 times higher than that without DCP addition. After 7 PIP cycles, density and open porosity of the final Cf/SiBCN composite with DCP addition are 1.73 g·cm -3 and ~10%, respectively, which are 143.0% higher and 30.3% lower compared with the composites without DCP addition. As a result, the flexural strength and elastic modulus of Cf/SiBCN composites with DCP addition (371 MPa and 31 GPa) are 1.74 and 1.60 times higher than that without DCP addition (213 MPa and 19.4 GPa).
Clinical phenotypes and genotypic characteristics of infantile-onset inflammatory bowel disease with interleukin-10 receptor A mutations in 22 Chinese children
Authors: Guan Dexiu , Zhang Jing , Guo Shu , Yu Feihong , Zhou Jin , Wang Guoli , Fu Libing , Li Zheng , Du Juan , Xu Xiwei
Published: August 2020

Background : Infantile-onset inflammatory bowel disease (IO-IBD) patients with interleukin-10/interleukin-10 receptor (IL-10/IL-10R) mutations suffer from more severe and intractable disease. We aimed to investigate the clinical phenotypes and genotypic characteristics of IO-IBD patients with IL-10RA gene mutations. Methods : Data on 22 patients with IO-IBD with IL-10RA gene mutations were retrospectively analyzed, and high-throughput sequencing was used to identify the IL-10RA gene mutations. Results : In 22 patients with IO-IBD with IL-10RA mutations, c.C301T (p.R101W) (86.4%, 19/22) and c.G537A (p.T179T) (36.4%, 8/22) were the most common ones, and one novel mutation was identified (c.635G>C (p.R212P)). Patients had extremely early onset of symptoms, with 81.8% (18/22) having disease onset within 1 month after birth, and median onset time was 8.5 (interquartile range: 3.0–24.0) days. In addition, 77.3% (17/22) of patients had recurrent perianal lesions. Oral ulcers and skin rashes were common extra-intestinal manifestations, accounting for 72.7% (16/22) and 63.6% (14/22), respectively. In this study, three patients underwent enterostomy and one experienced intestinal perforation repair. Thalidomide was used in five patients in this study: one achieved clinical remission, three were clinical improvement and one still had disease activity. Two patients underwent umbilical cord blood transplantation (UCBT) and remained stable. Follow-up showed that the mortality rate was as high as 45% (9/20). Conclusions : In 22 IO-IBD patients with IL-10RA mutations, the most common mutations were c.C301T (p.R101W) and c.G537A (p.T179T). Patient characteristics included extremely early onset of symptoms and extra-intestinal manifestations such as recurrent perianal lesions, oral ulcers, and skin rashes, which were common. UCBT and thalidomide might be effective treatments, although the mortality rate was high in this study.
Cross-national study of worrying, loneliness, and mental health during the COVID-19 pandemic: a comparison between individuals with and without infection in the family
Authors: Bonsaksen Tore , Leung Janni , Schoultz Mariyana , Thygesen Hilde , Price Daicia , Ruffolo Mary , Geirdal Amy Østertun
Published: August 2020

Background: As a response to the COVID-19 pandemic outbreak, strict national policies regarding public behavior were implemented in countries throughout the world, including Europe, America and Australia. Social distancing became the main policy for public behavior, in effect imposing radical changes in people’s everyday life. Thus, mental health may be affected at the general population level and not only among those who have been infected by the disease or have witnessed family members or close ones fall ill. Methods: A cross-sectional online survey was conducted in Norway, UK, USA and Australia during April/May 2020. Participants (n = 3810) were recruited via social media postings by the researchers and the involved universities. Differences between those with and without infection in the family were investigated with chi-square tests and independent t-tests. Multiple regression analyses were used to assess associations between sociodemographic variables and psychological outcomes (worry, loneliness and mental health) in both groups. Results: Compared to their counterparts, participants with infection in the family reported higher levels of worries about themselves (p < 0.05) and their family members (p < 0.001), and had poorer mental health (p < 0.05). However, the effect sizes related to the differences were small. The largest effect (d = 0.24) concerned worries about their immediate family. Poorer psychological outcomes were observed in those who were younger, female, unemployed, living alone and had lower levels of edcuation, yet with small effect sizes. Conclusions: In view of the small differences between those with and without infection, we generally conclude that the mental health effects of the COVID-19 situation are not limited to those who have been infected or have had infection within the family, but extend to the general population.
Factors associated with medial meniscal subluxation in knees with medial meniscus tears: a cross-sectional study
Authors: Liu Xinguang , Ding Ran , Liu Chen , Yang Bin , Wang Weiguo
Published: August 2020

Background Previous studies have indicated that medial meniscal subluxation (MMS) is associated with special types of medial meniscus tears (MMT) and chondral lesions. However, most of these studies lacked arthroscopic findings and did not adjust for possible confounders. The purpose of this study was to explore factors associated with MMS in patients with MMT using multivariate logistic regression analysis. Methods A retrospective analysis of 115 patients who underwent arthroscopic surgery for MMT was conducted. The medial meniscal extrusion (MME) distance was measured on a single mid-coronal magnetic resonance (MR) image, and the MMS group included patients with MME distance ≥3 mm (55 patients with 55 knees). Other patients were included as the control group (60 patients with 60 knees). Demographic and clinical data were collected as variates. A multivariate logistic regression analysis was performed to identify factors associated with MMS. Results In a univariate analysis, the Outerbridge classification (P=0.002) and the type of MMT (P<0.001) were significantly different between the MMS group and the control group. According to unadjusted and age- and body mass index (BMI)-adjusted multivariate logistic regression analysis, the type of MMT was an independent factor associated with MMS. Compared with horizontal tears, radial tears, posterior medial meniscus root tears (PMMRT) and complex tears had approximately 6-fold (adjusted OR 6.468, 95% CI 1.509–27.718, P=0.012), 10-fold (adjusted OR 10.324, 95% CI 1.719–61.989, P=0.011) and 4-fold (adjusted OR 4.458, 95% CI 1.602–12.408, P=0.004) higher associations with MMS, respectively. Conclusion The type of MMT was an independent factor associated with MMS in knees with MMT. Radial tears, PMMRT and complex tears were more likely than horizontal tears to result in MMS. The results suggest that MMT combined with MMS should be noted when managing MMT, especially radial tears, PMMRT and complex tears. Moreover, the results indicate that we must not only preserve the meniscus as much as possible but also restore its position to as close to normal as possible.
Downregulation of HBx restrains proliferation, migration and invasion of HepG2 cells
Authors: Huang Chaoqun , Liu Wei , Zhao Xiaochuan , Zhao Libin , Wang Fuxiang
Published: August 2020

The authors have withdrawn this preprint due to erroneous posting.
"Aneurysmal Bone Cyst of the Pelvis: A Systematic Literature Review"
Authors: Saeed Ayesha , Rometsch Elke , Hurtado-Chong Anahí
Published: August 2020

Background:Aneurysmal bone cysts (ABC) are rare benign, vascular, osteolytic bone lesions. Pelvic ABCs account for 8 -12% of these tumors and no clear guidelines for their treatment are available. To our knowledge, this is the first systematic literature review regarding pelvic ABCs. Our primary objective was to identify treatment modalities and to assess the bone healing, measured as the degree of radiological ossification. Secondary objectives were to describe demographics, tumor characteristics, clinical and functional outcomes and recurrence.Methods: Searches were conducted in PubMed, Cochrane Library, and Web of Science. Based on the scarcity of reports, inclusion criteria were kept broad and comprised primary or recurrent pelvic ABCs, with a minimum follow up of one year and available information on radiological ossification. Data was extracted on the individual patient-level and grouped according to treatment modality. Results:Forty-nine studies reporting on 194 patients were included. The level of evidence was low (29 case reports and 20 retrospective case series) and the reporting of outcomes inconsistent. Patients had a median age of 15 years and 52% were male. Five major treatment groups were identified and divided into 11 subgroups. The largest subgroup was curettage (23%) followed by selective arterial embolization (20%). Most ABCs were located in the ilium. Variations in mean tumor size (4.5-22.2cm) and degree of ossification (60-100%) depended on the treatment modality. Overall, in 77% cases the cyst ossified completely. Recurrence was reported in 22 patients (11%) and 2 patients (1%) died during the course of the treatment.Conclusion:Despite the low quality of reporting, this systematic review provides the first comprehensive overview of pelvic ABC treatment modalities and their radiological and clinical outcomes. Neoadjuvant sclero-embolic treatments appear to be used most in recent years, but further comparative studies and better quality of reporting are needed to determine their effectiveness. Quality of reporting should be improved by following reporting guidelines.Level of Evidence: IV
Infant’s safety in cesarean section surgery: a meta-synthesis
Authors: ghafouri raziyeh , Yaghmaei Minoo , Khodadadi Sepideh
Published: August 2020

Background: Patient safety is the most important clinical priority, especially in high-risk groups such as infants. Neonatal safety after a C-section is more challenging because despite all efforts and guidelines, patient safety is still a major challenge in the operating room. This meta-synthesis study aimed to investigate the factors affecting neonatal safety during a C-section and to provide improved strategies. Methods: This systematic review was carried out through meta-synthesis. A total of 112 articles were found and finally, 37 articles were selected for research after review. The articles were first reviewed by title and abstract and those which met the inclusion criteria were entered into the study. The inclusion criteria were papers in English and Persian, relevance to neonatal safety and being published before 2019. Exclusion criteria were papers that were not relevant to safety or neonate. In the next step, the quality of the articles was reviewed simultaneously by two separate researchers using the Strengthening the Reporting of Observational studies in Epidemiology" STROBE" and consolidated standards of reporting trials "CONSORT" Review Guidelines. Data were analyzed using content analysis. Results: The most important risk factors of neonatal safety during a C-section included anemia due to early cord clamping, jaundice due to delayed cord clamping, nosocomial infection, hypothermia and hyperthermia, inappropriate positioning of the infant, fall, medication error, operative damage and error in registering infants identity. Conclusion: For improvement of neonatal safety during C-section, it is important to consider teamwork, team and interdisciplinary continuous training through simulation, accurate identification of mothers and accurate registration of mothers and infants' identity on the identification band, accurate medication and right dosage, safely carrying and sleeping, observing infection control tips, maintaining operating room temperature and humidity, cord clamping after 30 seconds before birth and 2 minutes after birth.