bluuebunny/crossref_metadata_2025 huggingface dataset:
Priapism in a Patient with Rectal Adenocarcinoma
Authors: Dehar Navdeep , Tong Justin , Siddiqui Zain , Leveridge Michael , Tomiak Anna
Published: February 2023

Background: Priapism is a very rare complication of malignancy and is usually accompanied by locally advanced or widely metastatic disease. We describe a case of priapism arising in a 46-year-old male with localised rectal cancer that was responding to therapy. Case presentation: This patient had just completed two weeks of neoadjuvant, long-course chemoradiation when he presented with persistent painful penile erection. Assessment and diagnosis were delayed for more than 60 h, and although a cause could not be determined from imaging, a near complete radiological response of the primary rectal cancer was seen. His symptoms were refractory to urologic intervention and were associated with extreme psychological distress. He re-presented shortly thereafter with extensively metastatic disease in the lungs, liver, pelvis, scrotum, and penis; additionally, multiple venous thromboses were identified, including in the dorsal penile veins. His priapism was not reversible and was associated with a considerable symptom burden for the remainder of his life. His malignancy did not respond to first-line palliative chemotherapy or radiation, and his clinical course was further complicated by obstructive nephropathy, ileus, and genital skin breakdown with a suspected infection. We initiated comfort measures, and he ultimately died in hospital less than five months after his initial presentation. Conclusion: Priapism in cancer is usually related to tumour infiltration of the penis and corporal bodies resulting in poor venous and lymphatic drainage. The management is palliative and can include chemotherapy, radiation, surgical shunting, and potentially penectomy; however, conservative penis-sparing therapy may be reasonable in patients with limited life expectancy.
Optimising Early Childhood Educational Settings for Health Using Nature-Based Solutions: The Microbiome Aspect
Authors: Robinson Jake M. , Barrable Alexia
Published: February 2023

Early childhood is a time of rapid physiological, cognitive, and social development, affected by various environmental factors. The physical environment, including the environmental microbiome (the entire consortium of microorganisms and their theatre of activity in a given environment), plays an essential role in childhood development and can be shaped in ways to support health and wellbeing. In this Perspective article, we present considerations for early childhood education settings that wish to shape their outdoor and indoor environments to optimise human and ecosystem health. This is done in line with the latest evidence base on optimising health-supporting interactions between humans and environmental microbiota, but also in pedagogically and developmentally appropriate ways. Based on the Microbiome-Inspired Green Infrastructure (MIGI) principles, the considerations presented here not only support health through human–nature interactions and a healthier natural environment, but also promote a closer, reciprocal relationship between children and their natural environments.
Detecting Phishing Accounts on Ethereum Based on Transaction Records and EGAT
Authors: Zhou Xuanchen , Yang Wenzhong , Tian Xiaodan
Published: February 2023

In recent years, the losses caused by scams on Ethereum have reached a level that cannot be ignored. As one of the most rampant crimes, phishing scams have caused a huge economic loss to blockchain platforms and users. Under these circumstances, to address the threat to the financial security of blockchain, an Edge Aggregated Graph Attention Network (EGAT) based on the static subgraph representation of the transaction network is proposed. This study intends to detect Ethereum phishing accounts through the classification of transaction network subgraphs with the following procedures. Firstly, the accounts are used as nodes and the flow of transaction funds is used as directed edges to construct the transaction network graph. Secondly, the transaction record data of phishing accounts in the publicly available Ethereum are analyzed and statistical features of Value, Gas, and Timestamp values are manually constructed as node and edge features of the graph. Finally, the features are extracted and classified using the EGAT network. According to the experimental results, the Recall of the proposed method from the article is 99.3% on the dataset of phishing accounts. As demonstrated, the EGAT is more efficient and accurate compared with Graph2Vec and DeepWalk, and the graph structure features can express semantics better than manual features and simple transaction networks, which effectively improves the performance of phishing account detection.
A Review on Cell-Free Massive MIMO Systems
Authors: Kassam Joumana , Castanheira Daniel , Silva Adão , Dinis Rui , Gameiro Atílio
Published: February 2023

Cell-free massive multiple-input multiple-output (CF mMIMO) can be considered as a potential physical layer technology for future wireless networks since it can benefit from all the advantages of distributed antenna systems (DASs) and network MIMOs, such as macro-diversity gain, high channel capacity, and link reliability. CF mMIMO systems offer remarkable spatial degrees of freedom and array gains to mitigate the inherent inter-cell interference (ICI) of cellular networks. In such networks, several distributed access points (APs) together with precoding/detection processing can serve many users while sharing the same time-frequency resources. Each AP can be equipped with single or multiple antennas, and hence, can provide a consistently adequate service to all users regardless of their locations in the network. This paper presents a detailed overview of the current state-of-the-art on CF systems. First, it performs a literature review of the conventional CF and scalable user-centric (UC) CF mMIMO systems in terms of the limited capacity of the fronthaul links and the connection between APs and user equipments (UEs). As beyond networks will rely on higher frequency bands, it is of paramount importance to discuss the impact of beamforming techniques that are being investigated. Finally, some of the CF promising enabling technologies are presented to emphasize the main applications in these networks.
State Feedback and Deadbeat Predictive Repetitive Control of Three-Phase Z-Source Inverter
Authors: Peng Fan , Xie Weicai , Yan Jiande
Published: February 2023

In this paper, a composite control method combining repetitive control (RC) and deadbeat predictive control (DPC) is proposed to reduce the harmonic content of output voltage and improve the quality of voltage waveform, in order to solve the problem of voltage distortion caused by linear and nonlinear loads at the common grid-connected point of microgrid. First, the mathematical model of three-phase Z-source inverters is established, and the model is transformed into a state space expression. Then, Lyapunov’s theory is used to find the design conditions of the state feedback control law based on linear matrix inequality. Finally, the parameters of the controller are solved by linear matrix inequality (LMI), and the parameter design of the improved repetitive controller is optimized. Furthermore, the system response speed is improved, and the system stability and robustness are guaranteed by combining the deadbeat predictive control technology. The simulation and experimental results verify the accuracy and superiority of the proposed deadbeat predictive repetitive control (DPRC) based on parameter optimization.
Disturbance-Dependent Variation in Functional Redundancy Drives the Species Versus Functional Diversity Relationship across Spatial Scales and Vegetation Layers
Authors: Biswas Shekhar R , Yin Chaoqin , Gong Li , Qing Yanxia , Li Jialin
Published: February 2023

Since species’ traits are closely linked to ecosystem functioning, the species versus functional diversity relationship (the SD–FD relationship) is considered a valuable indicator of ecosystem health. However, the extent to which the SD–FD relationship varies among disturbed versus undisturbed subtropical forests and whether the conclusion depends on the spatial scale of the observation or vegetation layer remains unclear. In this study, using plots of 100 m2, 400 m2 and 2000 m2, we gathered species and functional diversity data for woody and non-woody vegetation from replicate sites of undisturbed mature forests versus disturbed shrubland and plantations from subtropical China. Our analyses indicated that the species richness versus functional richness relationship, as well as the species evenness versus functional evenness relationship, varies markedly among disturbed versus undisturbed forests and woody versus non-woody layers. Scale-dependent variations in the SD–FD relationship were evident mainly in the woody layers or evenness component. Additional analyses revealed that disturbance-dependent variation in the community-level functional redundancy and species-level functional uniqueness can partly explain the observed variation in the SD–FD relationships. Overall, our study demonstrated that the SD–FD relationships are positive, but the relationship’s slope varies with contexts, partly due to variations in community-level functional redundancy and species-level functional uniqueness.
On the Use of Knowledge Transfer Techniques for Biomedical Named Entity Recognition
Authors: Mehmood Tahir , Serina Ivan , Lavelli Alberto , Putelli Luca , Gerevini Alfonso
Published: February 2023

Biomedical named entity recognition (BioNER) is a preliminary task for many other tasks, e.g., relation extraction and semantic search. Extracting the text of interest from biomedical documents becomes more demanding as the availability of online data is increasing. Deep learning models have been adopted for biomedical named entity recognition (BioNER) as deep learning has been found very successful in many other tasks. Nevertheless, the complex structure of biomedical text data is still a challenging aspect for deep learning models. Limited annotated biomedical text data make it more difficult to train deep learning models with millions of trainable parameters. The single-task model, which focuses on learning a specific task, has issues in learning complex feature representations from a limited quantity of annotated data. Moreover, manually constructing annotated data is a time-consuming job. It is, therefore, vital to exploit other efficient ways to train deep learning models on the available annotated data. This work enhances the performance of the BioNER task by taking advantage of various knowledge transfer techniques: multitask learning and transfer learning. This work presents two multitask models (MTMs), which learn shared features and task-specific features by implementing the shared and task-specific layers. In addition, the presented trained MTM is also fine-tuned for each specific dataset to tailor it from a general features representation to a specialized features representation. The presented empirical results and statistical analysis from this work illustrate that the proposed techniques enhance significantly the performance of the corresponding single-task model (STM).
Calculation of Thermodynamic Characteristics and Sound Velocity for Two-Dimensional Yukawa Fluids Based on a Two-Step Approximation for the Radial Distribution Function
Authors: Fairushin Ilnaz I. , Mokshin Anatolii V.
Published: February 2023

We propose a simple two-step approximation for the radial distribution function of a one-component two-dimensional Yukawa fluid. This approximation is specified by the key parameters of the system: coupling parameter and screening parameter. On the basis of this approximation, analytical expressions are obtained for the same thermodynamic quantities as internal energy, internal pressure, excess entropy in the two-particle approximation, and also longitudinal sound velocity. The theoretical results show an agreement with the results obtained in the case of a true radial distribution function.
Influence of Processing and Digestion on the Stability, Bioac-Cessibility and Bioactivity of Food Polyphenols
Authors: Conte Angela , Martini Serena , Tagliazucchi Davide
Published: February 2023

In part, the role of polyphenols, as partially responsible components, for the protective effects of a fruit and vegetable-rich diet is an increasingly important area of human nutrition research [...]
Insights into the Genetic Determination of the Autotetraploid Potato Plant Height
Authors: Zhao Long , Zou Meiling , Jiang Sirong , Dong Xiaorui , Deng Ke , Na Tiancang , Wang Jian , Xia Zhiqiang , Wang Fang
Published: February 2023

Plant height is an important characteristic, the modification of which can improve the ability of stress adaptation as well as the yield. In this study, genome-wide association analysis was performed for plant height traits in 370 potato cultivars using the tetraploid potato genome as a reference. A total of 92 significant single nucleotide polymorphism (SNP) loci for plant height were obtained, which were particularly significant in haplotypes A3 and A4 on chromosome 1 and A1, A2, and A4 on chromosome 5. Thirty-five candidate genes were identified that were mainly involved in the gibberellin and brassinolide signal transduction pathways, including the FAR1 gene, methyltransferase, ethylene response factor, and ubiquitin protein ligase. Among them, PIF3 and GID1a were only present on chromosome 1, with PIF3 in all four haplotypes and GID1a in haplotype A3. This could lead to more effective genetic loci for molecular marker-assisted selection breeding as well as more precise localization and cloning of genes for plant height traits in potatoes.
Histories of Dermatan Sulfate Epimerase and Dermatan 4-O-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome
Authors: Mizumoto Shuji , Yamada Shuhei
Published: February 2023

Dermatan sulfate (DS) and its proteoglycans are essential for the assembly of the extracellular matrix and cell signaling. Various transporters and biosynthetic enzymes for nucleotide sugars, glycosyltransferases, epimerase, and sulfotransferases, are involved in the biosynthesis of DS. Among these enzymes, dermatan sulfate epimerase (DSE) and dermatan 4-O-sulfotranserase (D4ST) are rate-limiting factors of DS biosynthesis. Pathogenic variants in human genes encoding DSE and D4ST cause the musculocontractural type of Ehlers-Danlos syndrome, characterized by tissue fragility, joint hypermobility, and skin hyperextensibility. DS-deficient mice exhibit perinatal lethality, myopathy-related phenotypes, thoracic kyphosis, vascular abnormalities, and skin fragility. These findings indicate that DS is essential for tissue development as well as homeostasis. This review focuses on the histories of DSE as well as D4ST, and their knockout mice as well as human congenital disorders.
A Novel Homozygous Nonsense Variant in the DYM Underlies Dyggve-Melchior-Clausen Syndrome in Large Consanguineous Family
Authors: Bakar Abu , Shams Sulaiman , Bibi Nousheen , Ullah Asmat , Ahmad Wasim , Jelani Musharraf , Muthaffar Osama Yousef , Abdulkareem Angham Abdulrhman , Abujamel Turki S. , Haque Absarul , Naseer Muhammad Imran , Khan Bushra
Published: February 2023

(1) Background: Dyggve-Melchior-Clausen Syndrome is a skeletal dysplasia caused by a defect in the DYM gene (OMIM number 607461). Pathogenic variants in the gene have been reported to cause Dyggve-Melchior-Clausen (DMC; OMIM 223800) dysplasia and Smith-McCort (SMC; OMIM 607326) dysplasia. (2) Methods: In the present study, large consanguineous families with five affected individuals with osteochondrodysplasia phenotypes were recruited. The family members were analyzed by polymerase chain reaction for homozygosity mapping using highly polymorphic microsatellite markers. Subsequent to linkage analysis, the coding exons and exon intron border of the DYM gene were amplified. The amplified products were then sent for Sanger sequencing. The structural effect of the pathogenic variant was analyzed by different bioinformatics tools. (3) Results: Homozygosity mapping revealed a 9 Mb homozygous region on chromosome 18q21.1 harboring DYM shared by all available affected individuals. Sanger sequencing of the coding exons and exon intron borders of the DYM gene revealed a novel homozygous nonsense variant [DYM (NM_017653.6):c.1205T>A, p.(Leu402Ter)] in affected individuals. All the available unaffected individuals were either heterozygous or wild type for the identified variant. The identified mutation results in loss of protein stability and weekend interactions with other proteins making them pathogenic (4) Conclusions: This is the second nonsense mutation reported in a Pakistani population causing DMC. The study presented would be helpful in prenatal screening, genetic counseling, and carrier testing of other members in the Pakistani community.
Hydrodynamic Processes Controlling Sand Bank Mobility and Long-Term Base Stability: A Case Study of Arklow Bank
Authors: Creane Shauna , O’Shea Michael , Coughlan Mark , Murphy Jimmy
Published: February 2023

Offshore sand banks are an important resource for coastal protection, marine aggregates, and benthic habitats and are the site of many offshore wind farms. Consequently, a comprehensive understanding of the baseline processes controlling sand bank morphodynamics is imperative. This knowledge will aid the development of a long-term robust marine spatial plan and help address the environmental instability arising from anthropogenic activities. This study uses a validated, dynamically coupled, two-dimensional hydrodynamic and sediment transport model to investigate the hydrodynamic processes controlling the highly mobile upper layer of Arklow Bank, while maintaining overall long-term bank base stability. The results reveal a flood and ebb tidal current dominance on the west and east side of the bank, respectively, ultimately generating a large anticlockwise residual current eddy encompassing the entire bank. This residual current flow distributes sediment along the full length of the sand bank. The positioning of multiple off-bank anticlockwise residual current eddies on the edge of this cell is shown to influence east–west fluctuations of the upper slopes of the sand bank and act as a control on long-term stability. These off-bank eddies facilitate this type of movement when the outer flows of adjacent eddies, located on both sides of the bank, flow in a general uniform direction. Whereas they inhibit this east–west movement when the outer flows of adjacent eddies, on either side of the bank, flow in converging directions towards the bank itself. These residual eddies also facilitate sediment transport in and out of the local sediment transport system. Within Arklow Bank’s morphological cell, eight morphodynamically and hydrodynamically unique bank sections or ‘sub-cells’ are identified, whereby a complex morphodynamic–hydrodynamic feedback loop is present. The local east–west fluctuation of the upper slopes of the bank is driven by migratory on-bank stationary and transient clockwise residual eddies and the development of ‘narrow’ residual current cross-flow zones. Together, these processes drive upper slope mobility but maintain long-term bank base stability. This novel understanding of sand bank morphodynamics is applicable to bedforms in tidally dominated continental shelf seas outside the Irish Sea.
Chronic Resistance Training Effects on Serum Adipokines in Type 2 Diabetes Mellitus: A Systematic Review
Authors: Jiménez-Martínez Pablo , Ramirez-Campillo Rodrigo , Alix-Fages Carlos , Gene-Morales Javier , García-Ramos Amador , Colado Juan C.
Published: February 2023

(1) Background: Non-communicable diseases (NCD) are an important concern for public health because of their high rates of morbidity and mortality. A prevalent lifestyle-linked NCD is type 2 diabetes mellitus (T2D). Recently, molecular biomarkers secreted by adipocytes, called adipokines, have been linked with T2D and muscle function disturbances. However, the effects of resistance training (RT) interventions on adipokine levels in patients with T2D have not been systematically studied. (2) Methods: The PRISMA guidelines were followed. Searches for the studies were performed in the PubMed/MEDLINE and Web of Science electronic databases. Eligibility criteria included: (i) participants with T2D; (ii) RT interventions; (iii) randomized controlled trials; and (iv) measurement of serum adipokines. The PEDro scale was used to assess the methodological quality of the selected studies. Significant differences (p ≤ 0.05) and effect size were screened for each variable. (3) Results: Of the initial 2166 records, database search extraction yielded 14 studies to be included. The methodological quality of the included data was high (median PEDro score of 6.5). Analyzed adipokines in the included studies were leptin, adiponectin, visfatin, apelin, resistin, retinol-binding protein 4 (RBP4), vaspin, chemerin, and omentin. RT interventions (6–52 weeks; minimal effective duration >12 weeks) exert a meaningful effect on serum adipokine, (e.g., leptin) levels in T2D patients. (4) Conclusions: RT may be an alternative, but not an optimal, option in adipokine disruptions in T2D. Combined (i.e., aerobic and RT) long-term training may be considered the optimal intervention for treating adipokine level disturbances.
Diagnosis and Management of a Triple Infection with Leptospira spp., Hepatitis A Virus, and Epstein–Barr Virus: A Rare Occurrence with High Hepatotoxic Effect
Authors: Varga Norberth-Istvan , Mateescu Diana-Maria , Negrean Rodica Anamaria , Horhat Florin George , Bagiu Iulia-Cristina , Kodimala Shiva Charana , Bandi Satya Sai Sri , Horhat Razvan Mihai , Horhat Delia Ioana , Mot Ion Cristian , Miutescu Bogdan
Published: February 2023

The etiology of acute hepatic cytolysis is complex, and a thorough laboratory investigation is needed to find the causative agent and guide the clinician toward a specific treatment. Viral hepatitis A is a well-known cause of acute hepatitis, but other viruses and bacteria can lead to or contribute to liver damage. We report the case of a young male patient with triple infection with hepatitis A virus, Epstein–Barr virus, and Leptospira spp. To our knowledge, this is the first case of an HAV, EBV, and Leptospira triple infection, and it aims to bring awareness about the possibility of double or triple infection with such pathogens that are highly cytotoxic for the liver tissue since all three pathogens are known to cause or contribute to the onset of acute hepatitis. It was deduced that the source of the infection likely happened during a two-week visit to the countryside in Romania, returning 16 days before the onset of symptoms. The evolution was favorable receiving treatment with amoxicillin/clavulanic acid (1200 mg/8 h); glucose 5% 500 mL/day; 0.9% saline 500 mL/day; phenobarbital 1 tablet/day (200 mg); vitamins B1 and B6 and a complex of vitamin C and D3 and zinc. Lactulose syrup was also administered when the patient had no bowel movement for more than 24 h to prevent the onset of hepatic encephalopathy, and the patient was discharged after 20 days. This case suggests that a detailed anamnesis can raise suspicion about more uncommon causes of hepatic cytolysis and lead to a broader and more complex laboratory investigation, thus improving the quality of patient care. Yet, this is the only case previously reported to compare different management options and patient outcomes.
Decision Making in Shifts to Online Teaching: Analysing Reflective Narratives from Staff Working in African Higher Educational Institutions
Authors: Coughlan Tim , Goshtasbpour Fereshte , Mwoma Teresa , Makoe Mpine , Aubrey-Smith Fiona , Tanglang Nebath
Published: February 2023

Many higher education institutions moved from in-person to online teaching during the COVID-19 pandemic, but these shifts have a longer history and potential. They require challenging individual and collective decision making by staff, beyond their usual repertoire of practice. This paper, therefore, aims to understand the nature of decisions that staff made as they moved to online teaching, the reasons, processes, and reflections on the perceived impacts. Eighty-four participants with diverse roles connected to moving online from four institutions across Africa were purposively sampled. Using a constructivist paradigm and qualitative approach, participants were invited to describe decision-making experiences through short narratives with prompts around their context, decisions, and impacts. Twenty-two of these participants attended a workshop to augment the narrative data and identify good practices. Qualitative analysis directed by Activity Theory concepts revealed that decisions related to policy and rules, pedagogy, community, and technology were frequently cited by participants. The main objective expressed in these narratives was maintaining the continuity of education for students. However, mixed impacts were observed on student engagement, and further decisions were made in response to this. Common challenges related to tools and technology, and similarly, the biggest tension for implementing the decisions was found between tools and technology and the participants or their communities. Good practices include updating policies and introducing continuous assessment. Implications for reflective professional practice are discussed, including how previous practices are initially drawn on to try to reproduce in-person teaching online but then adapt in recognition of the tensions this raises.
Red-TE Homozygous Alleles of MdMYB10 Confer Full-Red Apple Fruit Skin in a High-Temperature Region
Authors: Wang Meili , Wang Yarong , Ding Tiyu , Yan Zhenli , Zhou Zhe , Li Cuiying , Yao Jia-Long , Zhang Hengtao
Published: February 2023

Apple is a major fruit crop grown worldwide and provides humans with an essential diet and health benefits. One of the health benefits is related to the accumulation of fruit anthocyanin, which also provides fruit with an attractive red colour. It is known that an MdMYB10 allele containing a transposable element (TE) insertion in its promoter (termed Red-TE allele) underlies anthocyanin accumulation and red colouration in the fruit skin of cultivated apples. However, the distribution of this Red-TE allele in wider Malus germplasm accessions is not clear. In this study, we showed that MdMYB10 RNA in fruit skin was specifically expressed from the Red-TE allele by using allele-specific expression analysis of transcriptome data. Apple cultivars and hybrids with homozygous Red-TE alleles showed stronger red colour than those with heterozygous alleles after analysing 65 cultivars and 337 hybrids. Furthermore, both hetero- and homozygous plants growing in the same high-temperature conditions had different colourations. However, the Red-TE allele was not detected in 16 wild apple accessions showing red skin, indicating that the red skin colour of these wild apples was not conferred by the Red-TE allele. These findings provide guidance for selecting cultivars able to develop consistent red colouration under high growth temperature conditions and open the opportunity for identifying novel genetic variants underpinning fruit red colouration in wild apple species.
Change in Time Perception Following the Place of Pre-Existence Technique
Authors: Pintimalli Andrea , Glicksohn Joseph , Marson Fabio , Di Giuseppe Tania , Ben-Soussan Tal Dotan
Published: February 2023

Time perception is closely related to spatial and bodily perception, yet little is known about how this interrelationship is impacted by meditation and biological sex. To examine this, we studied the effects of a stepwise application of three meditation techniques, from focused attention, to open monitoring to non-dual meditation, encompassed in the Place of Pre-Existence technique (PPEt) on the subjective perception of time, space and body using a pre–post research design. A total of 280 participants (mean age = 47.09 years; SD = 10.13; 127:153 males to females) completed the Subjective Time, Self, Space inventory before and after PPEt. Following PPEt, participants perceived time passing as slowing down, while time intensity, relaxation, ‘awareness of space’ and ‘awareness of body’ increased, suggesting heightened mindfulness to these constructs following the training. Awareness of space revealed to be modulated by biological sex and meditation expertise, with males showing a decrease of spatial awareness as a function of meditation expertise while females showed an opposite pattern. The speed and intensity of the experience of time both correlated with body and space awareness. In line with previous studies demonstrating a connection between relaxation and perception of time, a significant correlation was found between relaxation and the subjective experience of the intensity of time. The current results are discussed in the context of the embodied experience of time, and the Sphere Model of Consciousness.
A Scoping Review of Digital Well-Being in Early Childhood: Definitions, Measurements, Contributors, and Interventions
Authors: Cao Simin , Li Hui
Published: February 2023

Digital well-being concerns the balanced and healthy use of digital technology, and the existing studies in this area have focused on adolescents and adults. However, young children are more vulnerable to digital overuse and addiction than adults; thus, their digital well-being deserves empirical exploration. In this scoping review, we synthesized and evaluated 35 collected studies on young children’s digital use and their associated well-being that were published up to October of 2022 to understand the related definitions, measurements, contributors, and interventions. The synthesis of the evidence revealed that (1) there was no consensus about the definition of the concept of digital well-being; (2) there were no effective ways of measuring young children’s digital well-being; (3) both child factors (the duration and place of digital use, as well as the child’s demographic characteristics) and parent factors (digital use, parental perception, and mediation) contribute to young children’s well-being; and (4) there were some effective applications and digital interventions reported in the reviewed studies. This review contributes to the development of this concept by mapping the existing research on young children’s digital well-being, as well as proposing a model and identifying the research gaps for future studies.
Evaluating the Phytoremediation Potential of Eichhornia crassipes for the Removal of Cr and Li from Synthetic Polluted Water
Authors: Hayyat Muhammad Umar , Nawaz Rab , Irfan Ali , Al-Hussain Sami A. , Aziz Mehlil , Siddiq Zafar , Ahmad Sajjad , Zaki Magdi E. A.
Published: February 2023

Heavy metals like chromium (Cr) are hazardous pollutants for aquatic life in water bodies. Similarly, lithium (Li) is also an emerging contaminant in soil and water which later is taken up by plants. The aim of the present study is to evaluate the removal rate of Cr and Li by Eichhornia crassipes. The rate of the removal of Cr and Li by roots, stems, and leaves of E. crassipes were evaluated. The translocation factor (TF) and bioaccumulation factor (BAF) were also estimated. Roots of E. crassipes accumulated higher concentrations of Cr and Li as compared to the stems and leaves. BAF for Cr and Li showed that E. crassipes effectively accumulated the Cr and Li in the roots as compared to the stems and leaves. Statistical analysis showed that E. crassipes removed significant concentrations of Cr and Li (p ≤ 0.05). Thus, this study recommends that Cr and Li can be effectively removed by E. crassipes. High concentrations of Cr and Li could also be removed by E. crassipes. This technology could be used for the cleanup of the environment because it is eco-friendly and cost-effective.
Effects of Strength Training on Physical Fitness of Olympic Combat Sports Athletes: A Systematic Review
Authors: Cid-Calfucura Izham , Herrera-Valenzuela Tomás , Franchini Emerson , Falco Coral , Alvial-Moscoso Jorge , Pardo-Tamayo Carolina , Zapata-Huenullán Carolina , Ojeda-Aravena Alex , Valdés-Badilla Pablo
Published: February 2023

This review aimed to identify the effects of strength training programs on the physical fitness of Olympic combat sports (OCS) athletes. The systematic review included peer-reviewed articles that incorporated interventions that included pre- and post-intervention physical fitness assessment. The search was performed in the SCOPUS, PubMed, and Web of Science databases between April and September 2022. PRISMA and the TESTEX checklist were used to select and assess the methodological quality of the studies. Twenty studies with 504 participants (428 males and 76 females) were included. Significant improvements were found in athletes’ maximal dynamic and isometric strength, muscle power, flexibility, and balance. In addition, improvements in favor of the training groups in specific actions of judo, karate, fencing, and boxing were observed. In conclusion, interventions aimed at the development of muscle strength in OCS, specifically in judo, boxing, karate, wrestling, and fencing, proved to be beneficial at a physical fitness level, resulting in significant increases in favor of the training groups with OCS, which could be used by trainers and coaches to improve the physical performance of athletes.
eCONNECT Parent Group: An Online Attachment-Based Intervention to Reduce Attachment Insecurity, Behavioral Problems, and Emotional Dysregulation in Adolescence
Authors: Benzi Ilaria Maria Antonietta , Carone Nicola , Moretti Marlene , Ruglioni Laura , Tracchegiani Jacopo , Barone Lavinia
Published: February 2023

During adolescence, a secure parent–adolescent relationship promotes youths’ adjustment and psychological well-being. In this scenario, several studies have demonstrated the effectiveness of the CONNECT program, a 10-session, attachment-based parenting intervention that helps parents understand and reframe their parent–adolescent interactions, reducing adolescents’ insecure attachment and behavioral problems. Furthermore, recent years have witnessed a significant increase in the implementation of effective online versions of psychological interventions, emphasizing the opportunity for more agile and easier dissemination of evidence-based protocols. Therefore, this study aims to identify changes in adolescents’ attachment insecurity, behavioral problems, and parent–child affect regulation strategies, providing preliminary findings on an online, 10-session, attachment-based parenting intervention (eCONNECT). A total of 24 parents (20 mothers, 4 fathers; Mage = 49.33, SD = 5.32) of adolescents (Mage = 13.83 years, SD = 1.76, 45.8% girls) were assessed on their adolescents’ attachment insecurity (avoidance and anxiety) and behavioral problems (externalizing and internalizing), and on their affect regulation strategies in the parent–child interaction (adaptive reflection, suppression, and affect dysregulation) at three time points: before intervention (t0), after intervention (t1), and at a 2-month follow-up (t2). Mixed-effects regression models highlighted a reduction in adolescents’ internalizing problems (d = 0.11), externalizing problems (d = 0.29), and attachment avoidance (d = 0.26) after the intervention. Moreover, the reduction in externalizing problems and attachment avoidance remained stable at follow-up. Additionally, our findings highlighted a reduction in parent–child affect dysregulation. Results add preliminary evidence on the implementation suitability of an online attachment-based parenting intervention to change at-risk adolescents’ developmental trajectories by reducing attachment insecurity, behavioral problems, and parent–child affect regulation.
A City Surveillance System for Social Health Inequalities: The Case of Barcelona
Authors: Borrell Carme , Palència Laia , Marí-Dell’Olmo Marc , Bartoll Xavier , Gotsens Mercè , Pasarín M. Isabel , Artazcoz Lucía , Rodríguez-Sanz Maica , López María José , Pérez Katherine
Published: February 2023

Introduction: In the past, health inequalities were not prioritised in the political agenda of Barcelona. The change of city government (2015) was an opportunity to develop a Surveillance System for Social Health Inequalities in the city, which is described in this article. Methods: The design of the Surveillance System formed part of the Joint Action for Health Equity in Europe (JAHEE), funded by the European Union. Various steps were considered by the experts to set up the System: define its objectives, target population, domains and indicators, and sources of information; perform data analysis; implement and disseminate the system; define the evaluation; and perform regular data updates. Results: The System considers the following domains: social determinants of health, health-related with behaviours, use of healthcare, and health outcomes, and includes eight indicators. As axes of inequality, the experts chose sex, age, social class, country of origin, and geographical area. The Surveillance System for Social Health Inequalities is presented on a website including different types of figures. Conclusion: The methodology used to implement the Surveillance System can be used to implement similar systems in other urban areas around the world.
Motor Imagery Training Is Beneficial for Motor Memory of Upper and Lower Limb Tasks in Very Old Adults
Authors: Hilt Pauline M. , Bertrand Mathilde F. , Féasson Léonard , Lebon Florent , Mourey France , Ruffino Célia , Rozand Vianney
Published: February 2023

Human aging is associated with a decline in the capacity to memorize recently acquired motor skills. Motor imagery training is a beneficial method to compensate for this deterioration in old adults. It is not yet known whether these beneficial effects are maintained in very old adults (>80 years), who are more affected by the degeneration processes. The aim of this study was to evaluate the effectiveness of a mental training session of motor imagery on the memorization of new motor skills acquired through physical practice in very old adults. Thus, 30 very old adults performed 3 actual trials of a manual dexterity task (session 1) or a sequential footstep task (session 2) as fast as they could before and after a 20 min motor imagery training (mental-training group) or watching a documentary for 20 min (control group). Performance was improved after three actual trials for both tasks and both groups. For the control group, performance decreased in the manual dexterity task after the 20 min break and remained stable in the sequential footstep task. For the mental-training group, performance was maintained in the manual dexterity task after the 20 min motor imagery training and increased in the sequential footstep task. These results extended the benefits of motor imagery training to the very old population, showing that even a short motor imagery training session improved their performance and favored the motor memory process. These results confirmed that motor imagery training is an effective method to complement traditional rehabilitation protocols.
Deprescribing as an Opportunity to Facilitate Patient-Centered Care: A Qualitative Study of General Practitioners and Pharmacists in Japan
Authors: Ie Kenya , Machino Reiko , Albert Steven M. , Tomita Shiori , Kushibuchi Mio , Hirose Masanori , Matsuda Takahide , Okuse Chiaki , Ohira Yoshiyuki
Published: February 2023

Deprescribing has recently been applied to address polypharmacy, particularly among older adults. However, the characteristics of deprescribing that are likely to improve health outcomes have not been well studied. This study explored the experiences and perspectives of general practitioners and pharmacists with regard to deprescribing in older adults with multimorbidity. A qualitative study was conducted involving eight semi-structured focus group interviews with 35 physicians and pharmacists from hospitals, clinics, and community pharmacies. Thematic analysis was applied to identify themes using the theory of planned behavior as a guide. The results illustrated a metacognitive process, as well as influencing factors, through which healthcare providers commit to shared decision making for deprescribing. Healthcare providers acted on the basis of their attitudes and beliefs on deprescribing, the influence of subjective norms, and perceived behavioral control for deprescribing. These processes are influenced by factors such as drug class, prescribers, patients, deprescribing experience, and environment/education. Healthcare providers’ attitudes, beliefs, and behavioral control (along with deprescribing strategies) evolve in a dynamic interplay with experience, environment, and education. Our results can serve as a foundation for the development of effective patient-centered deprescribing to improve the safety of pharmaceutical care for older adults.
Clear Aligners Treatment of Class III Subdivision with an Extraction of a Lower Bicuspid
Authors: D’Antò Vincenzo , Valletta Rosa , De Simone Vittoria , Pisano Massimo , Martina Stefano
Published: February 2023

The aim of this study was to show a case of a Class III subdivision adult patient treated with clear aligners (CA) and the extraction of a lower bicuspid. A 19-year-old male with a class III canine and molar relationship on the right side and a deviation of lower dental midline to the left asked for an aesthetic treatment. He refused orthognathic surgical procedures, so he was offered a camouflage orthodontic treatment with the extraction of lower right first premolar to achieve a canine Class I relationship and to center the lower midline. The treatment was performed with clear aligners and the use of Class III elastics to maintain distal anchorage on the right side during the canine distalization. At the end of the treatment, the occlusal objectives were achieved.
Endocrine Disruption of Propylparaben in the Male Mosquitofish (Gambusia affinis): Tissue Injuries and Abnormal Gene Expressions of Hypothalamic-Pituitary-Gonadal-Liver Axis
Authors: Ma Yun , Li Yujing , Song Xiaohong , Yang Tao , Wang Haiqin , Liang Yanpeng , Huang Liangliang , Zeng Honghu
Published: February 2023

Propylparaben (PrP) is a widely used preservative that is constantly detected in aquatic environments and poses a potential threat to aquatic ecosystems. In the present work, adult male mosquitofish were acutely (4d) and chronically (32d) exposed to environmentally and humanly realistic concentrations of PrP (0, 0.15, 6.00 and 240 μg/L), aimed to investigate the toxic effects, endocrine disruption and possible mechanisms of PrP. Histological analysis showed time- and dose-dependent manners in the morphological injuries of brain, liver and testes. Histopathological alterations in the liver were found in 4d and severe damage was identified in 32d, including hepatic sinus dilatation, cytoplasmic vacuolation, cytolysis and nuclear aggregation. Tissue impairments in the brain and testes were detected in 32d; cell cavitation, cytomorphosis and blurred cell boundaries appeared in the brain, while the testes lesions contained spermatogenic cell lesion, decreased mature seminal vesicle, sperm cells gathering, seminiferous tubules disorder and dilated intercellular space. Furthermore, delayed spermatogenesis had occurred. The transcriptional changes of 19 genes along the hypothalamus–pituitary–gonadal–liver (HPGL) axis were investigated across the three organs. The disrupted expression of genes such as Ers, Ars, Vtgs, cyp19a, star, hsd3b, hsd17b3 and shh indicated the possible abnormal steroidogenesis, estrogenic or antiandrogen effects of PrP. Overall, the present results provided evidences for the toxigenicity and endocrine disruptive effects on the male mosquitofish of chronic PrP exposure, which highlights the need for more investigations of its potential health risks.
Assessment of Medical Students Burnout during COVID-19 Pandemic
Authors: Muaddi Mohammed A. , El-Setouhy Maged , Alharbi Abdullah A. , Makeen Anwar M. , Adawi Essa A. , Gohal Gassem , Alqassim Ahmad Y.
Published: February 2023

This study estimated the prevalence of burnout and its determinants among medical students at Jazan University during the COVID-19 pandemic. A total of 444 medical students completed an online survey containing the Maslach burnout inventory. The prevalence of burnout was 54.5%. Burnout reached its peak during the fourth year whereas it was the lowest in the internship year. Being a resident in mountain areas, being delayed in college-level, being divorced, and having divorced parents were all associated with an increased risk of burnout. During their time at medical school, students generally showed a trend of consistently high scores in the personal accomplishment subscale, a decreasing trend in the emotional exhaustion subscale, and an increasing trend in the depersonalization subscale. The most important predictive factor was having separated parents. Perceived study satisfaction appeared to be a significant protective factor in a dose–response manner. These findings suggest that burnout among medical students during the COVID-19 pandemic is a concern that should be monitored and prevented.
The Effect of Energy Use Rights Trading Policy on Environmental Performance: Evidence from Chinese 262 Cities
Authors: Le Dong , Ren Fei , Li Yusong
Published: February 2023

This study provides empirical evidence and policy inspiration for China to implement the energy use rights trading policy. Using 262 cities in China from 2005 to 2019 as samples, we employed the double difference method and mediation analysis to empirically measure the impact of energy use rights trading policy on environmental performance. First, energy use rights trading policy can improve urban environmental performance. This conclusion is valid as per the endogeneity test, parallel trend test, PSM-DID test, placebo test, and triple difference method. Second, heterogeneity analysis shows that the effect of the energy use rights trading policy on urban environmental performance will be different by the size of population. Energy use rights trading policy has the greatest effect on the environmental performance of resource-based cities. Meanwhile, compared to non-industrial base, the effect of the energy use rights trading policy on environmental performance is more pronounced in cities with older industrial base. Third, the mechanism test using the mediation effect model proved that the impact of energy use rights trading policy on environmental performance is achieved by improving the level of marketization and technological innovation.