bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Fagopyrum esculentum Moench germplasm based on agro-morphological traits and the rutin and quercetin content of seeds under spring cultivation
Authors: Rauf Muhammad , Yoon Hyemyeong , Lee Sukyeung , Hyun Do Yoon , Lee Myung-Chul , Oh Sejong , Choi Yu -Mi
Published: February 2020

Buckwheat is an important grain crop known for its nutritional value and content of bioactive compounds, particularly rutin. In this study, we characterized diverseFagopyrum esculentumMoench germplasm for the diversity of agro-morphological characteristics and the rutin and quercetin content in seeds under the spring cultivation. Of the 251 germplasm accessions assessed, 193 had red stems, 182 had a pale brown seed coat color, and 238 had ovate seeds. The times taken to reach 50% flowering and 80% maturity ranged from 38–45 to 73–95 days, respectively. The 1000-seed weight (TSW) varied from 21 to 42 g. Overall, the content of rutin and quercetin ranged from 7.22–47.86 to 0–1.22 mg/100 g DW, respectively. The number of days to flowering and maturity showed negative correlations with TSW and rutin and quercetin content. However, we found that at 73–80 days after sowing, early-maturing germplasm had significantly higher mean rutin content than either intermediate-or late-maturing germplasm. The TSW weight showed a positive correlation with the content of rutin and quercetin. We identified promising accessions based early maturity (< 80 days), higher seed weight (≥ 35 g) and higher content of rutin (≥ 35 mg/100 g DW) and quercetin (≥ 1 mg/100 g DW). These accessions will help to enhance grain yield and the rutin and quercetin content in existing buckwheat cultivars for spring cultivation.
Comparing Methods for Assessing Chimpanzee (Pan troglodytes schweinfurthii) Party Size: Observations, Camera Traps, and Bed Counts from a Savanna–Woodland Mosaic in the Issa Valley, Tanzania
Authors: Vink Daphne N. , Stewart Fiona A. , Piel Alex K.
Published: February 2020

Studying animal grouping behavior is important for understanding the causes and consequences of sociality and has implications for conservation. Chimpanzee (Pan troglodytes) party size is often assessed by counting individuals or extracted indirectly from camera trap footage or the number of nests. Little is known, however, about consistency across methods for estimating party size. We collected party size data for wild chimpanzees in the Issa valley, western Tanzania, using direct observations, camera traps, and nest counts over six years (2012–2018). We compared mean monthly party size estimates calculated using each method and found that estimates derived from direct observations were weakly positively correlated with those derived from camera traps. Estimates from nest counts were not significantly correlated with either direct observations or camera traps. Overall observed party size was significantly larger than that estimated from both camera traps and nest counts. In both the dry and wet seasons, observed party size was significantly larger than camera trap party size, but not significantly larger than nest party size. Finally, overall party size and wet season party size estimated from camera traps were significantly smaller than nest party size, but this was not the case in the dry season. Our results reveal how data collection methods influence party size estimates in unhabituated chimpanzees and have implications for comparative analysis within and across primate communities. Specifically, future work must consider how estimates were calculated before we can reliably investigate environmental influences on primate behavior.
Genetic characterization and deployment of a major gene for grain yield on chromosome arm 1BS in winter wheat
Authors: Kan Chia-Cheng , Jia Haiyan , Powers Carol , Carver Brett F. , Yan Liuling
Published: February 2020

Winter bread wheat (Triticum aestivum L., 2n = 6 × =42, AABBDD) cultivars “Duster” and “Billings” have occupied significant acreages in the Southern Great Plains for their outstanding yielding ability. In this study, we discovered a major quantitative trait locus (QTL) QYld.osu-1BS for grain yield in a population of 260 doubled haploid (DH) lines derived from the cross of Duster and Billings. When the population was tested under field conditions for 2 years, QYld.osu-1BS explained 13.9% and 23.5% of the total phenotypic variation. However, no crossover was observed among 40 genotyping-by-sequencing markers covering the region from the telomere to 25.3 Mb in the population of 260 DH lines. Furthermore, no crossover was observed in the region from the telomere to 18.4 Mb, when up to 4146 individual plants within F2:4 lines derived from the cross of Duster and Billings were screened. The 1BL-1RS translocation was not observed in the region with the abnormal recombination rate in Duster or Billings. Duster is a unique haplotype in the whole exome capture dataset, compared with 57 cultivars and breeding lines with various genetic backgrounds. Unique sequences of the QYld.osu-1BS allele for the higher grain yield in Duster were identified, and kompetitive allele specific PCR (KASP) markers for the unique sequences were developed for breeding of novel cultivars with increased grain yield in winter wheat.
Monitoring CD8a+ T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [64Cu]NOTA-CD8a PET Imaging
Authors: Kristensen Lotte K. , Christensen Camilla , Alfsen Maria Z. , Cold Sigrid , Nielsen Carsten H. , Kjaer Andreas
Published: February 2020

Purpose

Current response assessment systems for cancer patients receiving immunotherapy are limited. This is due to the associated inflammatory response that may confound the conventional morphological response evaluation criteria in solid tumors and metabolic positron emission tomography (PET) response criteria in solid. Recently, novel PET imaging techniques using radiolabeled antibodies and fragments have emerged as a particularly sensitive and specific modality for quantitative tracking of immune cell dynamics. Therefore, we sought to investigate the utility of Cu-64 labeled F(ab)′2 fragments for in vivo detection of CD8a+ T cells as a prognostic imaging biomarker of response to immunotherapy in an immunocompetent mouse model of colorectal cancer.

Procedures

[64Cu]NOTA-CD8a was produced by enzymatic digestion of rat-anti-mouse CD8a antibody (clone YTS169.4), purified yielding isolated CD8a-F(ab)′2 fragments and randomly conjugated with the 2-S-(isothiocyanatbenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA) chelator. NOTA-CD8a was radiolabeled with Cu-64 and injected into CT26 tumor-bearing mice for longitudinal assessment. To investigate the value of [64Cu]NOTA-CD8a PET imaging for assessment of treatment response, CT26 tumor-bearing mice were subjected to external radiation therapy (XRT) in combination with anti-CTLA-4 therapy. Imaging data was supported by flow cytometry and immunohistochemistry (IHC).

Results

Combination treatment with XRT and anti-CTLA-4 effectively inhibited tumor growth until day 22 post-therapy initiation (p = 0.0025) and increased the overall survival of mice compared to control (p = 0.0017). The [64Cu]NOTA-CD8a tumor-to-heart ratio was increased in XRT + anti-CTLA-4-treated mice on day 8 after initiation of therapy (p = 0.0246). Flow cytometry and IHC confirmed the increase in tumor-infiltrating CD8a+ cells in XRT + anti-CTLA-4-treated mice. Furthermore, [64Cu]NOTA-CD8a PET imaging distinguished responders and non-responders prior to treatment-induced changes in tumor volume among mice.

Conclusion

In the present study, we demonstrated that [64Cu]NOTA-CD8a was able to detect treatment-induced changes in CD8a+ infiltration in murine CT26 colon tumors following a common preclinical combination treatment protocol. Overall, [64Cu]NOTA-CD8a exhibited good prognostic and predictive value. We suggest that [64Cu]NOTA-CD8a PET imaging can be used as an early biomarker of response to therapy in preclinical models.
A new model for predicting irreducible water saturation in tight gas reservoirs
Authors: Su Yu-Liang , Fu Jin-Gang , Li Lei , Wang Wen-Dong , Zafar Atif , Zhang Mian , Ouyang Wei-Ping
Published: February 2020

The irreducible water saturation (Swir) is a significant parameter for relative permeability prediction and initial hydrocarbon reserves estimation. However, the complex pore structures of the tight rocks and multiple factors of the formation conditions make the parameter difficult to be accurately predicted by the conventional methods in tight gas reservoirs. In this study, a new model was derived to calculate Swir based on the capillary model and the fractal theory. The model incorporated different types of immobile water and considered the stress effect. The dead or stationary water (DSW) was considered in this model, which described the phenomena of water trapped in the dead-end pores due to detour flow and complex pore structures. The water film, stress effect and formation temperature were also considered in the proposed model. The results calculated by the proposed model are in a good agreement with the experimental data. This proves that for tight sandstone gas reservoirs the Swir calculated from the new model is more accurate. The irreducible water saturation calculated from the new model reveals that Swir is controlled by the critical capillary radius, DSW coefficient, effective stress and formation temperature.
Perception of Potential Health Risk of Climate Change and Utilization of Fans and Air Conditioners in a Representative Population of Hong Kong
Authors: Gao Yang , Chan Emily Y. Y. , Lam Holly C. Y. , Wang Aiwei
Published: February 2020

Climate change, especially as reflected in heat waves, is a rising threat worldwide. Appropriate use of cooling devices can protect people from health impacts during a heat wave. A population-based telephone survey was conducted in a representative sample of residents in Hong Kong to investigate ownership and use of domestic cooling devices, identify correlates, and examine their associations with risk perception of potential health impact of climate change. More than 90% of the 1002 respondents owned and used cooling devices at home. The majority (57.7%) perceived the potential health risk of climate change at a high level. However, risk perception had no relationship with ownership and utilization of cooling devices. Old people (≥ 65 years), the low-educated, those with low income, and those with chronic diseases were more likely not to use air conditioners when feeling hot. Our findings suggest that there are no signs showing people have taken more protective actions although half of respondents recognized climate change as a threat. Familial economic condition may be a major determinant in ownership and use of air conditioners at home. Old people and those with chronic diseases are at high risk of adverse exposure to climate change and therefore should be equipped with appropriate measures to use cooling devices.
Friction transitions and connections to third bodies for a Cd coating on steel substrate
Authors: Behera Priyadarshi , Lee Lisa , Rajagopalan Sriraman K. , Chromik Richard R. , Yue Stephen
Published: February 2020

Cd coating is used in aerospace industries from last five decades due to its sacrificial protection and lubrication properties. Although Cd coating is primarily used due to its sacrificial corrosion protection when applied on steel substrate, the added benefit of modifying the tribological behavior by acting as a lubricious layer gives it a leading-edge than other coatings. Often the measurement of friction coefficient (CoF) is reported as a value generated after full sliding cycle. This measurement of average CoF generally limits the study of local variation in CoF occurring within one sliding cycle, which can be significantly different with change in spatial position due to change in third body morphology. In this study, a linearly reciprocating sliding test is used to measure the CoF at a sampling rate of 800 Hz along the track length to generate triboscopic image with steel countersphere. The instantaneous CoF obtained with triboscopy is correlated with the wear track morphology using scanning electron microscope (SEM) and optical profilometer for variation in contact conditions. Tribological test performed in dry atmosphere shows an average CoF of 0.4 till the end of the test whereas with increase in relative humidity to 60%, the average CoF changes from 0.4 to 0.8 at the end of the test due to change in contact conditions. Soft Cd coating on low carbon steel substrate is used to study these variations in third body morphology.
NiSe2/Ni(OH)2 Heterojunction Composite through Epitaxial-like Strategy as High-Rate Battery-Type Electrode Material
Authors: Mei Hao , Huang Zhaodi , Xu Ben , Xiao Zhenyu , Mei Yingjie , Zhang Haobing , Zhang Shiyu , Li Dacheng , Kang Wenpei , Sun Dao Feng
Published: February 2020

Constructing heterojunction is a promising way to improve the charge transfer efficiency and can thus promote the electrochemical properties. Herein, a facile and effective epitaxial-like growth strategy is applied to NiSe2 nano-octahedra to fabricate the NiSe2-(100)/Ni(OH)2-(110) heterojunction. The heterojunction composite and Ni(OH)2 (performing high electrochemical activity) is ideal high-rate battery-type supercapacitor electrode. The NiSe2/Ni(OH)2 electrode exhibits a high specific capacity of 909 C g−1 at 1 A g−1 and 597 C g−1 at 20 A g−1. The assembled asymmetric supercapacitor composed of the NiSe2/Ni(OH)2 cathode and p-phenylenediamine-functional reduced graphene oxide anode achieves an ultrahigh specific capacity of 303 C g−1 at 1 A g−1 and a superior energy density of 76.1 Wh kg−1 at 906 W kg−1, as well as an outstanding cycling stability of 82% retention for 8000 cycles at 10 A g−1. To the best of our knowledge, this is the first example of NiSe2/Ni(OH)2 heterojunction exhibiting such remarkable supercapacitor performance. This work not only provides a promising candidate for next-generation energy storage device but also offers a possible universal strategy to fabricate metal selenides/metal hydroxides heterojunctions.
Making communities show respect for order
Authors: Vasiliauskaite Vaiva , Evans Tim S.
Published: February 2020

In this work we give a community detection algorithm in which the communities both respects the intrinsic order of a directed acyclic graph and also finds similar nodes. We take inspiration from classic similarity measures of bibliometrics, used to assess how similar two publications are, based on their relative citation patterns. We study the algorithm’s performance and antichain properties in artificial models and in real networks, such as citation graphs and food webs. We show how well this partitioning algorithm distinguishes and groups together nodes of the same origin (in a citation network, the origin is a topic or a research field). We make the comparison between our partitioning algorithm and standard hierarchical layering tools as well as community detection methods. We show that our algorithm produces different communities from standard layering algorithms.
Diversity of culturable heterotrophic bacteria from the Mariana Trench and their ability to degrade macromolecules
Authors: Zhao Xiuxiu , Liu Jiwen , Zhou Shun , Zheng Yanfen , Wu Yanhong , Kogure Kazuhiro , Zhang Xiao-Hua
Published: February 2020

The Mariana Trench is the deepest location on earth and harbors unique microbial communities as evidenced by 16S rRNA gene amplicon and metagenomic sequencing. Obtaining culturable microorganisms from the Mariana Trench will contribute to a further understanding of hadal biogeochemical processes and act as a unique microbial reservoir with potential applications. Here, 825 bacterial strains, identified by 16S rRNA gene sequencing, were isolated from 12 water depths (0–10,400 m) of the Mariana Trench with 2216E and R2A media at 4 °C or 28 °C on four cruises during 2015–2017. These bacteria belong to four phyla, nine classes, 27 orders, 45 families and 108 genera. Alphaproteobacteria, Gammaproteobacteria, Actinobacteria_c, Bacilli and Flavobacteriia were the most abundant classes, accounting for 37.9%, 33.0%, 11.8%, 8.6% and 8.0% of the total bacterial isolates, respectively. 2216E and R2A media were found to have a better selectivity to Bacilli and Flavobacteriia, respectively. Fifty strains were potential novel bacterial species with a 16S rRNA gene similarity < 98.65%, and a higher percentage of novel strains were obtained from R2A than 2216E medium. Additionally, 301 (150 species) out of 354 strains (178 species) selected from each depth could degrade at least one of the ten kinds of macromolecules tested. These results indicate that there is a high diversity of culturable bacteria in the Mariana Trench and they can produce a variety of extracellular enzymes. Our study provides a valuable resource of microorganisms for investigating their biogeochemical roles in the Mariana Trench and for industrial applications.
Accumulation rates (2009–2017) in Southeast Greenland derived from airborne snow radar and comparison with regional climate models
Authors: Montgomery Lynn , Koenig Lora , Lenaerts Jan T. M. , Kuipers Munneke Peter
Published: February 2020

Since the year 2000, Greenland ice sheet mass loss has been dominated by a decrease in surface mass balance rather than an increase in solid ice discharge. Southeast Greenland is an important region to understand how high accumulation rates can offset increasing Greenland ice sheet meltwater runoff. To that end, we derive a new 9-year long dataset (2009–17) of accumulation rates in Southeast Greenland using NASA Operation IceBridge snow radar. Our accumulation dataset derived from internal layers focuses on high elevations (1500–3000 m) because at lower elevations meltwater percolation obscured internal layer structure. The uncertainty of the radar-derived accumulation rates is 11% [using Firn Densification Model (FDM) density profiles] and the average accumulation rate ranges from 0.5 to 1.2 m w.e. With our observations spanning almost a decade, we find large inter-annual variability, but no significant trend. Accumulation rates are compared with output from two regional climate models (RCMs), MAR and RACMO2. This comparison shows that the models are underestimating accumulation in Southeast Greenland and the models misrepresent spatial heterogeneity due to an orographically forced bias in snowfall near the coast. Our dataset is useful to fill in temporal and spatial data gaps, and to evaluate RCMs where few in situ measurements are available.
A state-of-the-art review of the socio-ecological correlates of volunteerism among older adults
Authors: Lu Peiyi , Xu Cai , Shelley Mack
Published: February 2020

The health and social benefits of volunteering behaviours by older adults are well acknowledged. However, few review articles have been concerned with the correlates/dimensions of older adults’ volunteerism. Some focused only on the North American context or reviewed studies only up to 2008. This study reviewed the recent global literature in the past decade about the correlates of older adults’ volunteerism. We carried out a literature search in PsycINFO, Social Services Abstracts, Sociological Abstracts and Google Scholar to identify empirical journal publications about the correlates of older adults’ (age 60+) volunteerism from 2008 to 2019. Among 112 initially eligible papers, 41 were selected. Findings were synthesised using the framework of the Socioecological Model. Existing studies mainly have used quantitative methodologies and were conducted within the context of a single Western country. Motivations included higher education, morale and mentality, previous experiences, social network, community cohesion and organisational management. Major barriers were health and financial constraints. Few studies focused on macro-level correlates. Irrelevant and confounding correlates were also discussed. We suggest practitioners recruit and retain older volunteers by identifying their needs and optimising management within the organisation. Policy makers should create a supportive environment and increase resource accessibility. Future research could conduct cross-cultural comparisons, use diverse methodologies and embrace more correlates, especially at the macro-level.
Monotone Lagrangians in of minimal Maslov number n + 1
Authors: KONSTANTINOV MOMCHIL , SMITH JACK
Published: February 2020

We show that a monotone Lagrangian L in ${\mathbb{C}}{\mathbb{P}}^n$ of minimal Maslov number n + 1 is homeomorphic to a double quotient of a sphere, and thus homotopy equivalent to ${\mathbb{R}}{\mathbb{P}}^n$. To prove this we use Zapolsky’s canonical pearl complex for L over ${\mathbb{Z}}$, and twisted versions thereof, where the twisting is determined by connected covers of L. The main tool is the action of the quantum cohomology of ${\mathbb{C}}{\mathbb{P}}^n$ on the resulting Floer homologies.
Associations of dietary carbohydrate and fatty acid intakes with cognition among children
Authors: Naveed Sehrish , Venäläinen Taisa , Eloranta Aino-Maija , Erkkilä Arja T , Jalkanen Henna , Lindi Virpi , Lakka Timo A , Haapala Eero A
Published: February 2020

Objective:

To investigate the cross-sectional associations of dietary carbohydrate and fatty acid intakes with cognition in mid-childhood.

Design:

Dietary carbohydrate and fatty acid intakes were assessed using 4-d food records, and cognition was evaluated using the Raven’s Coloured Progressive Matrices (RCPM) score. The cross-sectional associations of dietary carbohydrate and fatty acid intakes with cognition were investigated using linear regression analyses adjusted for age, sex, body fat percentage, household income, parental education and daily energy intake.

Setting:

The baseline examinations of the Physical Activity and Nutrition in Children study.

Participants:

A population-based sample of 487 children (250 boys, 237 girls) aged 6–8 years living in the city of Kuopio, Finland.

Results:

A higher dietary intake of fructose (standardised regression coefficient,β= 0·24,P< 0·001), total fibre (β= 0·16,P= 0·02) and soluble fibre (β= 0·15,P= 0·02) was associated with a higher RCPM score in boys. Other dietary carbohydrates and fatty acids, including total carbohydrates, glucose, sucrose, starch, insoluble fibre, total fat, SFAs, MUFAs, PUFAs, palmitic acid (C16), stearic acid (C18), linoleic acid (C18:2), α-linoleic acid (C18:3), arachidonic acid (C20:4), EPA (C20:5n-3) and DHA (C22:6n-6), were not associated with the RCPM score in boys. Dietary carbohydrates or fatty acids were not associated with the RCPM score in girls.

Conclusions:

Higher dietary fructose and fibre intakes were associated with better cognition in boys, but not in girls. Dietary fatty acids were not related to cognition in boys or in girls.
The efficacy of litter management strategies to prevent morbidity and mortality in broiler chickens: a systematic review and network meta-analysis
Authors: Sargeant Jan M. , Bergevin Michele D. , Churchill Katheryn , Dawkins Kaitlyn , Deb Bhumika , Dunn Jennifer , Hu Dapeng , Logue Catherine M. , Meadows Shannon , Moody Carly , Novy Anastasia , O'Connor Annette M. , Reist Mark , Sato Yuko , Wang Chong , Winder Charlotte B.
Published: February 2020

A systematic review and network meta-analysis (NMA) were conducted to address the question, ‘What is the efficacy of litter management strategies to reduce morbidity, mortality, condemnation at slaughter, or total antibiotic use in broilers?’ Eligible studies were clinical trials published in English evaluating the efficacy of litter management in broilers on morbidity, condemnations at slaughter, mortality, or total antibiotic use. Multiple databases and two conference proceedings were searched for relevant literature. After relevance screening and data extraction, there were 50 trials evaluating litter type, 22 trials evaluating litter additives, 10 trials comparing fresh to re-used litter, and six trials evaluating floor type. NMAs were conducted for mortality (61 trials) and for the presence or absence of footpad lesions (15 trials). There were no differences in mortality among the litter types, floor types, or additives. For footpad lesions, peat moss appeared beneficial compared to straw, based on a small number of comparisons. In a pairwise meta-analysis, there was no association between fresh versus used litter on the risk of mortality, although there was considerable heterogeneity among studies (I2= 66%). There was poor reporting of key design features in many studies, and analyses rarely accounted for non-independence of observations within flocks.
How to read and interpret the results of a Bayesian network meta-analysis: a short tutorial
Authors: Hu D. , O'Connor A. M. , Winder C. B. , Sargeant J. M. , Wang C.
Published: February 2020

In this manuscript we use realistic data to conduct a network meta-analysis using a Bayesian approach to analysis. The purpose of this manuscript is to explain, in lay terms, how to interpret the output of such an analysis. Many readers are familiar with the forest plot as an approach to presenting the results of a pairwise meta-analysis. However when presented with the results of network meta-analysis, which often does not include the forest plot, the output and results can be difficult to understand. Further, one of the advantages of Bayesian network meta-analyses is in the novel outputs such as treatment rankings and the probability distributions are more commonly presented for network meta-analysis. Our goal here is to provide a tutorial for how to read the outcome of network meta-analysis rather than how to conduct or assess the risk of bias in a network meta-analysis.
Medical care in armed conflict: Perpetrator discourse in historical perspective
Authors: McLean Duncan
Published: February 2020

Although the Geneva Conventions have been successively revised since 1864, norms regarding the protection of medical care have been frequently disregarded. Despite current claims of international humanitarian law in crisis, comparing historic levels of violations with contemporary incidents is quantitatively challenging. Reviewing past reactions and justifications used by perpetrators of attacks on medical care can, however, be revealing. Based on a series of emblematic cases, qualitative analysis of perpetrator discourse can contribute to a better understanding of why the protection of medical care in armed conflict continues to be problematic to this day, notably through the rationales given for attacks, which have remained remarkably consistent over time.
Heritability of Curve Patterns in Oral Glucose Tolerance Test
Authors: Dalgård Christine , Möller Soren , Kyvik Kirsten O.
Published: February 2020

Type 2 diabetes, which is caused by both genetic and environmental factors, may be diagnosed using the oral glucose tolerance test (OGTT). Recent studies demonstrated specific patterns in glucose curves during OGTT associated with cardiometabolic risk profiles. As the relative contribution of genetic and environmental influences on glucose curve patterns is unknown, we aimed to investigate the heritability of these patterns. We studied twins from the Danish GEMINAKAR cohort aged 18–67 years and free from diabetes at baseline during 1997–2000; glucose concentrations were measured three times during a 2-h OGTT. Heterogeneity of the glucose response during OGTT was examined with latent class mixed-effects models, evaluating goodness of fit by Bayes information criterion. The genetic influence on curve patterns was estimated using quantitative genetic modeling based on linear structural equations. Overall, 1455 twins (41% monozygotic) had valid glucose concentrations measured from the OGTT, and four latent classes with different glucose response patterns were identified. Statistical modeling demonstrated genetic influence for belonging to a specific class or not, with heritability estimated to be between 45% and 67%. During ∼12 years of follow-up, the four classes were each associated with different incidence of type 2 diabetes. Hence, glucose response curve patterns associated with type 2 diabetes risk appear to be moderately to highly heritable.
The Cauchy 5 Small, Low‐Volume Lunar Shield Volcano: Evidence for Volatile Exsolution‐Eruption Patterns and Type 1/Type 2 Hybrid Irregular Mare Patch Formation
Authors: Qiao Le , Head James W. , Wilson Lionel , Ling Zongcheng
Published: February 2020

The lunar shield volcano Cauchy 5, sitting at the low diameter‐height‐volume end of the population, is the only known example containing two different types of Irregular Mare Patches (IMPs) in very close association: (1) the pit crater interior Type 1 IMP composed of bleb‐like mounds surrounded by a hummocky and blocky floor unit and (2) Type 2 IMPs, small, often optically immature pits less than ~5 m deep, located on the generally block‐deficient shield flanks. A four‐phase lunar magma ascent/eruption model predicts that during a relatively brief eruption, low magma rise rates maximize volatile exsolution in lava filling the pit crater. Bubble‐rich magmas overtop the pit crater and form extremely vesicular flows on the shield flanks. Exposure of the flanking flows to vacuum produces a fragmental layer of exploded glassy bubble walls. Subsequent second boiling upon cooling of the flanking flow interiors releases additional volatiles which migrate and collect, forming magmatic foams and gas pockets. As magma rise rates slow, trapped gas and magmatic foam build up below the cooling pit crater floor. Magmatic foams are extruded to form Type 1 IMP deposits. Type 2 IMPs on the flanks are interpreted to be due primarily to subsequent impacts causing collapse of the flow surface layer into the extremely vesicle‐ and void‐rich flow interior. Anomalously young pit crater floor/shield flank crater retention ages compared with surrounding maria ages may be due to effects of Cauchy 5 substrate characteristics (extreme micro‐ and macroporosity, foamy nature, and glassy auto‐regolith) on superposed crater formation and retention.
Simulating the Reiner Gamma Swirl: The Long‐Term Effect of Solar Wind Standoff
Authors: Deca J. , Hemingway D. J. , Divin A. , Lue C. , Poppe A. R. , Garrick‐Bethell I. , Lembège B. , Horányi M.
Published: February 2020

The Reiner Gamma swirl is a prime location to investigate the lunar albedo patterns and their colocation with magnetic anomalies. The precise relationship between impinging plasma and the swirl, and, in particular, how these interactions vary over the course of a lunar day, remains an open issue. Here we use a fully kinetic particle‐in‐cell code, coupled with a magnetic field model based on orbital‐altitude observations, and simulate the interaction with the Reiner Gamma anomaly for all plasma regimes the region is exposed to along a typical orbit, including different solar wind incidence angles and the Moon's crossing through the terrestrial magnetosphere. Consistent with the hypothesis that swirls form as a result of plasma interactions with near‐surface magnetic fields, we show that the energy flux profile produces a pattern similar to Reiner Gamma's alternating bright and darkly colored bands, but only when integrating over the full lunar orbit. We additionally show that including He
as a self‐consistent plasma species improves the match.
Mare Deposits Identification and Feature Analysis in Mare Australe Based on CE‐2 CELMS Data
Authors: Meng Z.G. , Chen S.B. , Zheng Y.C. , Cheng W.M. , Zhu Y.Q. , Cai Z.C. , Zhang Y.Z. , Cao W. , Hou L.L.
Published: February 2020

The microwave signal has the penetration capability, which provides a potential chance to improve understanding of the mare deposits and the formation process of Mare Australe, a complex, extensive, and poorly understood region on the Moon. In this paper, the Chang'E‐2 microwave radiometer (CELMS) data were selected and processed to evaluate the microwave thermal emission features of the mare deposits in Mare Australe. After comparison, the dTB map at 3.0 GHz is employed. The results are as follows. (a) The possible cryptomare is much more extensive in Australe region than that identified with optical data. (b) The basaltic volcanism is re‐understood as three major episodes. (c) The high dTB anomaly is interpreted as the location of the vent areas in the mare patches. (d) The K‐means algorithm was first used to process the CELMS data, and the identified linear and ring structures indicate some important information about the formation processes of Mare Australe. These special findings will be of fundamental significance to better understand the basaltic volcanism and the evolution of the lunar surface.
Seasonal Subsurface Thaw Dynamics of an Aufeis Feature Inferred From Geophysical Methods
Authors: Terry Neil , Grunewald Elliot , Briggs Martin , Gooseff Michael , Huryn Alexander D. , Kass M. Andy , Tape Ken D. , Hendrickson Patrick , Lane John W.
Published: February 2020

Aufeis are sheets of ice unique to cold regions that originate from repeated flooding and freezing events during the winter. They have hydrological importance associated with summer flows and winter insulation, but little is known about the seasonal dynamics of the unfrozen sediment layer beneath them. This layer may support perennial groundwater flow in regions with otherwise continuous permafrost. For this study, ground penetrating radar (GPR) were collected in September 2016 (maximum thaw) and April 2017 (maximum frozen) at the Kuparuk aufeis field on the North Slope of Alaska. Supporting surface nuclear magnetic resonance data were collected during the maximum frozen campaign. These point‐in‐time geophysical data sets were augmented by continuous subsurface temperature data and periodic Structure‐from‐Motion digital elevation models collected seasonally. GPR and difference digital elevation model data showed up to 6 m of ice over the sediment surface. Below the ice, GPR and nuclear magnetic resonance identified regions of permafrost and regions of seasonally frozen sediment (i.e., the active layer) underlain by a substantial lateral talik that reached >13‐m thickness. The seasonally frozen cobble layer above the talik was typically 3‐ to 5‐m thick, with freezing apparently enabled by relatively high thermal diffusivity of the overlying ice and rock cobbles. The large talik suggests that year‐round groundwater flow and coupled heat transport occurs beneath much of the feature. Highly permeable alluvial material and discrete zones of apparent groundwater upwelling indicated by geophysical and ground temperature data allows direct connection between the aufeis and the talik below.
Correction: Multi-trait single-step genomic prediction accounting for heterogeneous (co)variances over the genome
Authors: Karaman Emre , Lund Mogens S. , Su Guosheng
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Simple-to-use nomogram for evaluating the incident risk of moderate-to-severe LEAD in adults with type 2 diabetes: A cross-sectional study in a Chinese population
Authors: Zhao Xin , Zhang Xiaomei , Ran Xingwu , Xu Zhangrong , Ji Linong
Published: February 2020

This study aimed to analyze the clinical characteristics of lower extremity atherosclerotic disease (LEAD) in Chinese adult type 2 diabetes (T2D) patients, and also explored the risk factors for LEAD and developed simple-to-use nomograms for LEAD and lesion degree in these patients. We retrospectively studied 4422 patients (male = 2084; female = 2338) with T2D who were ≥50. Based on lower extremity arterial ultrasound findings, we divided the patients into three groups: normal, mild, and moderate-to-severe group. The factors related to LEAD in patients with T2D were analyzed by logistic regression analysis. The risk factors for moderate-to-severe LEAD included: high HbA1c (OR = 1.07 95% CI 1.02–1.13), diabetic peripheral neuropathy (OR = 1.93 95% CI 1.57–2.37), and diabetic retinopathy (OR = 1.26 95%CI 1.01–1.57). The overall areas under the receiver operating characteristic curves for the nomograms for predicting the risks of LEAD and moderate-to-severe LEAD in adult T2D patients were 0.793 (95%CI 0.720, 0.824) and 0.736 (95%CI 0.678, 0.795), respectively. The developed nomograms are simple to use and enable preliminary visual prediction of the risk and degree of LEAD in Chinese T2D patients over 50 years. The nomograms are accurate to a certain degree and provide a clinical basis for predicting the occurrence and progression of LEAD.
Publisher Correction: Diversified Floral Resource Plantings Support Bee Communities after Apple Bloom in Commercial Orchards
Authors: Heller Sarah , Joshi Neelendra K. , Leslie Timothy , Rajotte Edwin G. , Biddinger David J.
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Improved Gait Parameters After Orthotic Treatment in Children with Infantile Tibia Vara
Authors: Alsancak Serap , Guner Senem , Kınık Hakan
Published: February 2020

The aim of this study was to investigate the modification of gait kinematics before and after orthotic treatment in patients with ITV. Vicon instrumented gait analysis was performed on three patients with ITV, pre and post treatment. Orthoses were applied a total of eighteen participants with ITV who were 25–38 months. 34 extremities were treated and radiographic evidence evaluated before and after orthotic treatment. Treatment duration for orthotic treatment ranged between 11 and 41 (25.9 ± 10.0) months. Only three patients were evaluated in gait analysis due to application difficulties. Three patients kinematic and kinetic instrumented gait analysis were found flatfoot, varus and internal rotation of the foot, hip flexion and external rotation. Study were reported an improvement in gait kinematics after orthotic treatment, in patients with ITV.
Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes
Authors: Montesanto Alberto , Bonfigli Anna Rita , De Luca Maria , Crocco Paolina , Garagnani Paolo , Marasco Elena , Pirazzini Chiara , Giuliani Cristina , Romagnoli Fabio , Franceschi Claudio , Passarino Giuseppe , Testa Roberto , Olivieri Fabiola , Rose Giuseppina
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Extending the Spectrum of Dysgraphia: A Data Driven Strategy to Estimate Handwriting Quality
Authors: Asselborn Thibault , Chapatte Mateo , Dillenbourg Pierre
Published: February 2020

This paper proposes new ways to assess handwriting, a critical skill in any child’s school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children’s Handwriting) is used to assess children’s handwriting in French-speaking countries. Any child with a BHK score above a certain threshold is diagnosed as ‘dysgraphic’, meaning that they are then eligible for financial coverage for therapeutic support. We previously developed a version of the BHK for tablet computers which provides rich data on the dynamics of writing (acceleration, pressure, and so forth). The underlying model was trained on dysgraphic and non-dysgraphic children. In this contribution, we deviate from the original BHK for three reasons. First, in this instance, we are interested not in a binary output but rather a scale of handwriting difficulties, from the lightest cases to the most severe. Therefore, we wish to compute how far a child’s score is from the average score of children of the same age and gender. Second, our model analyses dynamic features that are not accessible on paper; hence, the BHK is useful in this instance. Using the PCA (Principal Component Analysis) reduced the set of 53 handwriting features to three dimensions that are independent of the BHK. Nonetheless, we double-checked that, when clustering our data set along any of these three axes, we accurately detected dysgraphic children. Third, dysgraphia is an umbrella concept that embraces a broad variety of handwriting difficulties. Two children with the same global score can have totally different types of handwriting difficulties. For instance, one child could apply uneven pen pressure while another one could have trouble controlling their writing speed. Our new test not only provides a global score, but it also includes four specific score for kinematics, pressure, pen tilt and static features (letter shape). Replacing a global score with a more detailed profile enables the selection of remediation games that are very specific to each profile.
Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus
Authors: Westerhuis Brenda , ten Hulscher Hinke , Jacobi Ronald , van Beek Josine , Koopmans Marion , Rimmelzwaan Guus , Meijer Adam , van Binnendijk Rob
Published: February 2020

H7 avian influenza viruses represent a major public health concern, and worldwide outbreaks raise the risk of a potential pandemic. Understanding the memory B cell response to avian (H7) influenza virus infection in humans could provide insights in the potential key to human infection risks. We investigated an epizootic of the highly pathogenic A(H7N7) in the Netherlands, which in 2003 led to infection of 89 persons and one fatal case. Subtype-specificity of antibodies were determined for confirmed H7N7 infected individuals (cases) (n = 19), contacts of these cases (n = 21) and a comparison group controls (n = 16), by microarray, using recombinant hemagglutinin (HA)1 proteins. The frequency and specificity of memory B cells was determined by detecting subtype-specific antibodies in the culture supernatants from in vitro stimulated oligoclonal B cell cultures, from peripheral blood of cases and controls. All cases (100%) had high antibody titers specific for A(H7N7)2003 (GMT > 100), whereas H7-HA1 antigen binding was detected in 29% of contacts and 31% of controls, suggesting that some of the H7 reactivity stems from cross reactive antibodies. To unravel homotypic and heterotypic responses, the frequency and specificity of memory B cells were determined in 2 cases. Ten of 123 HA1 reactive clones isolated from the cases bound to only H7- HA1, whereas 5 bound both H7 and other HA1 antigens. We recovered at least four different epitopal reactivities, though none of the H7 reactive antibodies were able to neutralize H7 infections in vitro. Our study serologically confirms the infection with H7 avian influenza viruses, and shows that H7 infection triggers a mixture of strain -specific and cross-reactive antibodies.
Optically tunable terahertz chiral metasurface based on multi-layered graphene
Authors: Masyukov Maxim , Vozianova Anna , Grebenchukov Alexander , Gubaidullina Kseniya , Zaitsev Anton , Khodzitsky Mikhail
Published: February 2020

Active manipulation of the polarization states at terahertz frequencies is crucially helpful for polarization-sensitive spectroscopy, having significant applications such as non-contact Hall measurements, vibrational circular dichroism measurements and anisotropy imaging. The weakness of polarization manipulation provided by natural materials can be overcomed by chiral metamaterials. Chiral metamaterials have a huge potential to achieve the necessary polarization effects, hence they provide the basis for applications such as ultracompact polarization components. Terahertz chiral metamaterials that allow dynamic polarization modulation of terahertz waves are of great practical interest and still challenging. Here, we show that terahertz metasurface based on the four conjugated “petal” resonators integrated with multi-layered graphene (MLG) can enable dynamically tunable chiroptical response using optical pumping. In particular, a change of ellipticity angle of 20° is observed around 0.76 THz under optical pumping by a 980 nm continuous wave (CW) laser. Furthermore, using temporal coupled-mode theory, our study also reveals that the chiroptical response of the proposed multi-layered graphene-based metasurface is strongly dependent on the influence of optical pumping on the loss parameters of resonance modes, leading to actively controllable polarization states of the transmitted terahertz waves. The present work paves the way for the realization of fundamental terahertz components capable for active polarization manipulation.
Association between Dietary Quality and Prediabetes based on the Diet Balance Index
Authors: He Dingliu , Qiao Yanan , Xiong Suting , Liu Siyuan , Ke Chaofu , Shen Yueping
Published: February 2020

Dietary quality is an important factor influencing prediabetes, but few studies have applied the Chinese Diet Balance Index (DBI-16) to evaluate the dietary quality of individuals with prediabetes and explore the associations between dietary quality and prediabetes. In our study, the lower-bound score, higher-bound score and diet quality distance, were respectively calculated to assess dietary quality based on each food group. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (95%CI) of unfavorable dietary quality leading to prediabetes in every subgroup. The results were shown that individuals with prediabetes had excessive intake in the categories of cereals, salt and inadequate intake in vegetables, fish and diet variety than participants without prediabetes (all P < 0.01). Unfavourable dietary quality was significantly associated with an increased risk of prediabetes (OR: 1.45, 95%CI: 1.29–1.63), especially among the subjects who lived in rural areas (OR: 1.63, 95%CI: 1.25–1.76), those who had abdominal obesity (OR: 1.58, 95%CI: 1.36–1.85), those who smoked (OR: 1.58, 95%CI: 1.30–1.93), those who consumed alcohol (OR: 1.57, 95%CI: 1.28–1.93) and those who did not drink tea (OR: 1.64, 95%CI: 1.42–1.88). In Conclusion, unfavourable dietary quality was significantly associated with an increased risk of prediabetes.
T-13 and T-26, the novel taxanes with improved oral bioavailability in rats
Authors: Jing Yun-Rong , Zhou Wei , Wang Xiang-Yang
Published: February 2020

In an attempt to improve the oral bioavailability of taxanes, a series of new analogues were synthesized and tested in a panel of human tumor cell lines and cellular permeability assays. Compounds T-13 and T-26 showed potent cytotoxicity and exhibited the highest permeability, so they were selected for pharmacokinetic studies. Here, pharmacokinetics of T-13 and T-26 were studied after intravenous injection (5 mg/kg) and oral administration (60 mg/kg) in male Sprague-Dawley (S.D.) rats, respectively. Plasma concentrations were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The oral bioavailability of T-13 and T-26 was determined to be 10.71% and 65.79%, respectively. Compounds T-13 and T-26 were both poor substrates of P-glycoprotein (P-gp), and they had a much higher bioavailability than paclitaxel, especially T-26. T-26 with good oral bioavailability represented a potential candidate for potent antitumor activity given oral administration.