bluuebunny/crossref_metadata_2025 huggingface dataset:
UAT ADS-B Data Anomalies and the Effect of Flight Parameters on Dropout Occurrences
Authors: Tabassum Asma , Semke William
Published: June 2018

An analysis of the performance of automatic dependent surveillance-broadcast (ADS-B) data received from the Grand Forks, North Dakota International Airport was carried out in this study. The purpose was to understand the vulnerabilities of the universal access transceiver (UAT) ADS-B system and recognize the effects on present and future air traffic control (ATC) operation. The Federal Aviation Administration (FAA) mandated all the general aviation aircraft to be equipped with ADS-B. The aircraft flying within United States and below the transition altitude (18,000 feet) are more likely to install a UAT ADS-B. At present, unmanned aircraft systems (UAS) and autonomous air traffic control (ATC) towers are being integrated into the aviation industry and UAT ADS-B is a basic sensor for both class 1 and class 2 detect-and-avoid (DAA) systems. As a fundamental component of future surveillance systems, the anomalies and vulnerabilities of the ADS-B system need to be identified to enable a fully-utilized airspace with enhanced situational awareness. The data received was archived in GDL-90 format, which was parsed into readable data. The anomaly detection of ADS-B messages was based on the FAA ADS-B performance assessment report. The data investigation revealed ADS-B message suffered from different anomalies including dropout, missing payload, data jump, low confidence data, and altitude discrepancy. Among those studied, the most severe was dropout and 32.49% of messages suffered from this anomaly. Dropout is an incident where ADS-B failed to update within a specified rate. Considering the potential danger being imposed, an in-depth analysis was carried out to characterize message dropout. Three flight parameters were selected to investigate their effect on dropout. Statistical analysis was carried out and the Friedman Statistical Test identified that altitude affected dropout more than any other flight parameter.
The Technical Efficiency of High Schools: The Case of a Greek Prefecture
Authors: Halkiotis Dimitrios , Konteles Ilias , Brinia Vasiliki
Published: June 2018

Scarce human and fiscal resources of high value are spent in the field of education. Thus, the concept of efficiency, and particularly technical efficiency, that refers to the maximization of outputs at a given set of inputs, can be a possible contribution to the design of education policy and administration; mostly at a time of economic crisis as this in Greece, research could assist in formulating proposals on how resources are actually used within education structures/services, as well as in providing guidance to those responsible for the internal allocation of funds so as to secure greater educational results and benefits. The aim of this study is to measure the degree of technical efficiency of the 23 High Schools (Lyceums) in the Prefecture of Fthiotida in Greece, using the model of Data Envelopment Analysis and explore the factors that could interrelate with these measurements. The results provide evidence that a low percentage of school units (34.8%) achieves maximum technical efficiency. Proposals for improving the technical efficiency of the specific schools are also made.
Method of Estimating Human Orientation Using Array Antenna
Authors: Shiraki Nobuyuki , Chen Zhixiong , Sasakawa Dai , Honma Naoki , Nakayama Takeshi , Iizuka Shoichi
Published: June 2018

This paper presents a method that uses microwaves to estimate human body orientation. The antennas are arranged to surround the human and observe vital signs such as respiration and heart beat from the microwaves reflected from the human. Since the signal reflected from the front of the human will fluctuate the most, mainly due to respiration, human body orientation is estimated by finding the antenna that captures the largest rhythmic fluctuation. In experiments with three subjects, the median value of angular error of human orientation was 9.01∼23.35°.
More Discussions on Intrinsic Frequency Detection Capability of Full-Rate Linear Phase Detector in Clock and Data Recovery
Authors: Byun Sangjin
Published: June 2018

The full-rate linear phase detector (PD) has not only phase detection capability but also single-sided frequency detection capability intrinsically. Previously, this fact has been discovered by researching the phase and frequency characteristics of the combined full-rate linear PD and charge pump (CP) under the condition that the ratio of the received data frequency (fDATA) and the recovered clock frequency (fCLK) is set as an integer number. In this paper, for completeness of the theory, the phase and frequency characteristics of the combined full-rate linear PD and CP are studied again while the ratio of fDATA and fCLK is set as a general rational number. Additionally, theoretical analyses of the lock-in range and the lock time of the referenceless single-loop clock and data recovery (CDR) including the full-rate linear PD are newly developed and verified. The calculated lock times by the analysis results agree well with the measured lock times from the MATLAB Simulink simulations.
Scenario Analysis of Carbon Emissions of Beijing-Tianjin-Hebei
Authors: Zhou Jianguo , Jin Baoling , Du Shijuan , Zhang Ping
Published: June 2018

This paper utilizes the generalized Fisher index (GFI) to decompose the factors of carbon emission and exploits improved particle swarm optimization-back propagation (IPSO-BP) neural network modelling to predict the primary energy consumption CO2 emissions in different scenarios of Beijing-Tianjin-Hebei region. The results show that (1) the main factors that affect the region are economic factors, followed by population size. On the contrary, the factors that mainly inhibit the carbon emissions are energy structure and energy intensity. (2) The peak year of carbon emission changes with the different scenarios. In a low carbon scenario, the carbon emission will have a decline stage between 2015 and 2018, then the carbon emission will be in the ascending phase during 2019–2030. In basic and high carbon scenarios, the carbon emission will peak in 2025 and 2028, respectively.
Fault Detection and Location of IGBT Short-Circuit Failure in Modular Multilevel Converters
Authors: Jiang Bin , Gong Yanfeng , Li Yan
Published: June 2018

A single fault detection and location for Modular Multilevel Converter (MMC) is of great significance, as numbers of sub-modules (SMs) in MMC are connected in series. In this paper, a novel fault detection and location method is proposed for MMC in terms of the Insulated Gate Bipolar Translator (IGBT) short-circuit failure in SM. The characteristics of IGBT short-circuit failures are analyzed, based on which a Differential Comparison Low-Voltage Detection Method (DCLVDM) is proposed to detect the short-circuit fault. Lastly, the faulty IGBT is located based on the capacitor voltage of the faulty SM by Continuous Wavelet Transform (CWT). Simulations have been done in the simulation software PSCAD/EMTDC and the results confirm the validity and reliability of the proposed method.
Wet Oxidation of Fine Soil Contaminated with Petroleum Hydrocarbons: A Way towards a Remediation Cycle
Authors: Collivignarelli Maria Cristina , Vaccari Mentore , Abbà Alessandro , Canato Matteo , Sorlini Sabrina
Published: June 2018

The aim of this experimental study was to assess the feasibility of using a wet oxidation (WO) process for treating fine soil with a high level of total petroleum hydrocarbons (TPHs). Two samples of soil were spiked with two different contaminants (motor oil, and motor oil + diesel). The samples were subjected to a WO bench plant test, where the effect of the main process parameters (i.e., temperature and reaction time) on the removal of TPHs was investigated. Results show that the WO process is effective for the decontamination of hydrocarbons, and a strong reduction (>85%) can be obtained with the typical working conditions of a full-scale plant (temperature = 250 °C, reaction time = 30 min). The solid residue resulting from the WO process was characterized in order to evaluate the recovery options. In terms of chemical characterization, the contents of the pollutants comply with the Italian regulations for commercial and industrial site use. Moreover, the results of the leaching test suggested that these residues could be reused for ceramic and brick manufacturing processes.
Designing Thinning Operations in 2nd Age Class Pine Stands—Economic and Environmental Implications
Authors: Mederski Piotr S. , Venanzi Rachele , Bembenek Mariusz , Karaszewski Zbigniew , Rosińska Martyna , Pilarek Zenon , Luchenti Irene , Surus Michał
Published: June 2018

The application of a harvester for thinning operations in young stands can pose several dilemmas. Firstly, the value of the timber obtained should be higher than the cost of the thinning operation—this is especially difficult with young stands, where the timber is of a small size and productivity is low. In addition, small harvesters used for thinning usually have short cranes, less than 10 m in length, which is rather impractical in stands where the distance between strip roads is a standard 20 m. The aim of this research was to select the best mechanised thinning operation, taking into account economic suitability and some environmental aspects (damage to the remaining stand and density of strip roads). The research was carried out in a 31-year-old pine stand (11.27 ha) in which three different harvester thinning (T) operations were designed: TM1) with midfield and one harvester pass, TM2) with midfield and two harvester passes and TWM) without midfield and one harvester pass. In all the proposed operations, a Vimek 404 T5 harvester (with a 4.6 m-long crane) and a Vimek 606 TT forwarder were used. The most economic operation was TWM, with a total cost of €13.73 m−3, while TM1 was 13% more expensive at €15.51 m−3. The lowest level of damage, 1.5%, was recorded in TWM, while in TM1 the level was 2.1%. The TWM operation required a net of strip roads twice as dense as in TM1. Taking into account all the analysed aspects, a thinning operation with midfield and one harvester pass is recommended when using the Vimek 404 T5 harvester and the Vimek 606 TT forwarder in the first thinning of a pine stand.
Acetogen Communities in the Gut of Herbivores and Their Potential Role in Syngas Fermentation
Authors: Yang Chunlei
Published: June 2018

To better understand the effects of host selection on gut acetogens and their potential role in syngas fermentation, the composition and hydrogenotrophic features of acetogen populations in cow and sheep rumens, rabbit ceca, and horse feces were studied. The acetogens detected in horses and rabbits were more phylogenetically diverse than those in cows and sheep, suggesting that the host species plays an important role in shaping gut acetogen populations. Acetogen enrichments from these animals presented good capacities to use hydrogen, with acetate as the major end product. Minor propionate, butyrate, and isovalerate were also produced. During 48 h of incubation, acetogen enrichments from horse consumed 4.75 moles of H2 to every 1 mole of acetate—significantly lower than rabbits, cows, and sheep (5.17, 5.53, and 5.23 moles, respectively) (p < 0.05)—and produced significantly more butyrate (p < 0.05). Enrichments from cows and sheep produced significantly higher amounts of propionate when compared to rabbits or horses (p < 0.05); enrichments from sheep produced the highest amounts of isovalerate (p < 0.05). These short chain fatty acids are important precursors for the synthesis of biofuel products, suggesting that gut contents of herbivores may be promising sources for harvesting functional acetogens for biofuel production.
A Comparison of Energy Recovery by PATs against Direct Variable Speed Pumping in Water Distribution Networks
Authors: Morani Maria Cristina , Carravetta Armando , Del Giudice Giuseppe , McNabola Aonghus , Fecarotta Oreste
Published: June 2018

Water systems are usually considered low efficiency systems, due to the large amount of energy that is lost by water leakage and dissipated by pressure reducing valves to control the leakage itself. In water distribution networks, water is often pumped from the source to an elevated tank or reservoir and then supplied to the users. A large energy recovery can be realized by the installation of energy production devices (EPDs) to exploit the excess of pressure that would be dissipated by regulation valves. The feasibility of such a sustainable strategy depends on the potential of energy savings and the amount of energy embedded in water streams, assessed by means of efficiency measures. Alternatively, energy savings can be pursued if the water is directly pumped to the network, bypassing the elevated reservoir. This study focuses on the comparison of two solutions to supply a real network, assessed as a case study. The first solution consists of water pumping to a reservoir, located upstream of the network; the excess of energy is saved by the employment of a pump as turbine (PAT). The second scenario is characterized by a smaller pressure head since a direct variable speed pumping is performed, bypassing the reservoir. The comparison has been carried out in terms of required energy, assessed by means of a new energy index and two literature efficiency indices. Furthermore, differing design conditions have been analyzed by varying the pumping head of both the scenarios, corresponding to different distances and elevation of the water source.
Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling
Authors: Dong Lile , Han Xu , Tao Xufeng , Xu Lina , Xu Youwei , Fang Linlin , Yin Lianhong , Qi Yan , Li Hua , Peng Jinyong
Published: June 2018

We previously reported the effects of the total flavonoids (TFs) from Rosa laevigata Michx fruit against carbon tetrachloride-induced liver damage, non-alcoholic fatty liver disease, and liver ischemia-reperfusion injury. However, there have been no papers reporting the role of R. laevigata TFs against lipopolysaccharide (LPS)-induced liver injury. In this paper, liver injury in mice was induced by LPS, and R. Laevigata extract was intragastrically administered to the mice for 7 days. Biochemical parameters in serum and liver tissue were examined, and pathological changes were observed by transmission electron microscopy, hematoxylin and eosin (H&E) and Oil Red O staining. The results showed that the TFs markedly reduced serum ALT (alanine transferase), AST (aspartate transaminase), TG (total triglyceride), and TC (total cholesterol) levels and relative liver weights and improved liver pathological changes. In addition, the TFs markedly decreased tissue MDA (malondialdehyde) level and increased the levels of SOD (superoxide dismutase) and GSH-Px (glutathione peroxidase). A mechanistic study showed that the TFs significantly increased the expression levels of Nrf2 (nuclear erythroid factor2-related factor 2), HO-1 (heme oxygenase-1), NQO1 (NAD(P)H dehydrogenase (quinone 1), GCLC (glutamate-cysteine ligase catalytic subunit), and GCLM (glutamate-cysteine ligase regulatory subunit) and decreased Keap1 (Kelch-like ECH-associated protein 1) level by activating FXR (farnesoid X receptor) against oxidative stress. Furthermore, the TFs markedly suppressed the nuclear translocation of NF-κB (nuclear factor-kappa B) and subsequently decreased the expression levels of IL (interleukin)-1β, IL-6, HMGB-1 (high -mobility group box 1), and COX-2 (cyclooxygenase-2) by activating FXR and FOXO3a (forkhead box O3) against inflammation. Besides, the TFs obviously reduced the expression levels of SREBP-1c (sterol regulatory element-binding proteins-1c), ACC1 (acetyl-CoA carboxylase-1), FASN (fatty acid synthase), and SCD1 (stearoyl-coenzyme A desaturase 1), and improved CPT1 (carnitine palmitoyltransferase 1) level by activating FXR to regulate lipid metabolism. Our results suggest that TFs exhibited protective effect against LPS-induced liver injury by altering FXR-mediated oxidative stress, inflammation, and lipid metabolism, and should be developed as an effective food and healthcare product for the therapy of liver injury in the future.
Propagation of Fatigue Cracks in Friction of Brittle Hydrogels
Authors: Yamaguchi Tetsuo , Sato Ryuichiro , Sawae Yoshinori
Published: June 2018

In order to understand fatigue crack propagation behavior in the friction of brittle hydrogels, we conducted reciprocating friction experiments between a hemi-cylindrical indenter and an agarose hydrogel block. We found that the fatigue life is greatly affected by the applied normal load as well as adhesion strength at the bottom of the gel–substrate interface. On the basis of in situ visualizations of the contact areas and observations of the fracture surfaces after the friction experiments, we suggest that the mechanical condition altered by the delamination of the hydrogel from the bottom substrate plays an essential role in determining the fatigue life of the hydrogel.
Hyperphagia and Obesity in Prader–Willi Syndrome: PCSK1 Deficiency and Beyond?
Authors: Ramos-Molina Bruno , Molina-Vega María , Fernández-García José C. , Creemers John W.
Published: June 2018

Prader–Willi syndrome (PWS) is a complex genetic disorder that, besides cognitive impairments, is characterized by hyperphagia, obesity, hypogonadism, and growth impairment. Proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, a rare recessive congenital disorder, partially overlaps phenotypically with PWS, but both genetic disorders show clear dissimilarities as well. The recent observation that PCSK1 is downregulated in a model of human PWS suggests that overlapping pathways are affected. In this review we will not only discuss the mechanisms by which PWS and PCSK1 deficiency could lead to hyperphagia but also the therapeutic interventions to treat obesity in both genetic disorders.
Investigating the Molecular Genetic Basis of Cytoplasmic Sex Determination Caused by Wolbachia Endosymbionts in Terrestrial Isopods
Authors: Badawi Myriam , Moumen Bouziane , Giraud Isabelle , Grève Pierre , Cordaux Richard
Published: June 2018

In animals, sexual differences between males and females are usually determined by sex chromosomes. Alternatively, sex may also be determined by vertically transmitted intracellular microbial endosymbionts. The best known cytoplasmic sex manipulative endosymbiont is Wolbachia which can, for instance, feminize genetic males into phenotypic females in the terrestrial isopod Armadillidium vulgare. However, the molecular genetic basis of cytoplasmic sex determination is unknown. To identify candidate genes of feminization induced by Wolbachia strain wVulC from A. vulgare, we sequenced the genome of Wolbachia strain wCon from Cylisticus convexus, the most closely related known Wolbachia strain to wVulC that does not induce feminization, and compared it to the wVulC genome. Then, we performed gene expression profiling of the 216 resulting wVulC candidate genes throughout host developmental stages in A. vulgare and the heterologous host C. convexus. We identified a set of 35 feminization candidate genes showing differential expression during host sexual development. Interestingly, 27 of the 35 genes are present in the f element, which is a piece of a feminizing Wolbachia genome horizontally transferred into the nuclear genome of A. vulgare and involved in female sex determination. Assuming that the molecular genetic basis of feminization by Wolbachia and the f element is the same, the 27 genes are candidates for acting as master sex determination genes in A. vulgare females carrying the f element.
Risk of Cardiovascular Diseases and Cancer in Later Life: The Role of Age at First Marriage
Authors: Liu Hui , Zhang Zhenmei , Choi Seung-won
Published: June 2018

The objective of this study was to examine how age at first marriage is related to the risk of developing cardiovascular diseases and cancer in later life. We analyzed longitudinal data from a nationally representative sample of 2129 older adults (born in the 1940s or earlier) in the National Social Life, Health, and Aging Project. We found that for men in this cohort, the age at first marriage that was related to the lowest risk of cardiovascular diseases (CVD) and cancer in later life was the early 30s; men who first married at either younger or older ages had significantly higher odds of experiencing CVD and cancer. Interestingly, for women in this cohort, the age at first marriage was not related to the risk of either CVD or cancer.
The Role of Religion, Spirituality and/or Belief in Positive Ageing for Older Adults
Authors: Malone Joanna , Dadswell Anna
Published: June 2018

(1) Background: The concept of positive ageing is gaining recognition as an approach to better understand the lives of older adults throughout the world. Positive ageing encompasses the various ways in which older adults approach life challenges associated with ageing and how certain approaches allow older adults to age in a more positive way. This paper makes a contribution to the field by examining the role of religion, spirituality and/or belief in relation to positive ageing; (2) Methods: Qualitative focus groups with 14 older adults living in West London explored the role and importance religion, spirituality and/or belief held in their everyday lives and how this could be incorporated into the idea of positive ageing; (3) Results: Religion, spirituality and/or belief were found to play a number of roles in the everyday lives of the older adults, including being a source of strength, comfort and hope in difficult times and bringing about a sense of community and belonging; (4) Conclusion: This paper argues that religion, spirituality and/or belief should be included within positive ageing literature and be viewed as a type of support (amongst multiple others) that helps older adults to live positive lives despite the many challenges of ageing.
Growth and Physiological Responses of Lettuce Grown under Pre-Dawn or End-Of-Day Sole-Source Light-Quality Treatments
Authors: Chinchilla Skarleth , Izzo Luigi G. , Van Santen Edzard , Gómez Celina
Published: June 2018

The objective of this study was to evaluate growth and physiological responses of ‘Cherokee’ and ‘Waldmann’s Green’ lettuce (Lactuca sativa) exposed to small changes in light quality and intensity within a 24-h period. Three pre-dawn (PD; 0600 to 0700) and three end-of-day (EOD; 2100 to 2200) treatments were evaluated in the study, each providing 50 ± 2 µmol·m−2·s−1 of either blue, red, or broadband white light from light-emitting diodes (LEDs). To account for the main daily light integral (DLI), broadband white LEDs provided 210 ± 2 µmol·m−2·s−1 from 0700 to 2200 or from 0600 to 2100 for the PD or EOD treatments, respectively. A control treatment was included which provided 200 ± 2 µmol·m−2·s−1 of white light from 0600 to 2200. All treatments provided a DLI of 11.5 mol·m−2·day−1 over a 16-h photoperiod. Regardless of cultivar, no treatment difference was measured for hypocotyl length or leaf number. However, plants grown under EOD-blue or PD-white had up to 26% larger leaves than those grown under PD-red and 20% larger leaves than control. In addition, plants grown under EOD-blue produced up to 18% more shoot fresh mass compared to those grown under control, EOD-red, or PD-red. Contrasts for gas-exchange data collected during the main photoperiod showed that light quality was not significant within PD or EOD for any of the parameters evaluated. However, regardless of light quality, stomatal conductance (gs) and transpiration (E) were up to 34% and 42% higher, respectively, for EOD-grown plants compared to control. Our results suggest that 1 h of low intensity EOD-blue light has the potential to promote lettuce growth by increasing leaf area and shoot fresh mass when the main DLI from sole-source lighting is provided by broadband white LEDs.
Lung Cancer Risk and Low (≤50 μg/L) Drinking Water Arsenic Levels for US Counties (2009–2013)—A Negative Association
Authors: Lamm Steven H. , Boroje Isabella J. , Ferdosi Hamid , Ahn Jaeil
Published: June 2018

While epidemiologic studies clearly demonstrate drinking water with high levels of arsenic as a significant risk factor for lung cancer, the evidence at low levels (≤50 μg/L) is uncertain. Therefore, we have conducted an ecological analysis of recent lung cancer incidence for US counties with a groundwater supply of <50 μg/L, the historical limit for both the EPA and WHO. Data sources used included USGS for arsenic exposure, NCI for lung cancer outcome, and CDC and US Census Bureau forcovariates. Poisson log-linear models were conducted for male, female, and total populations using for exposure median county arsenic level, maximum arsenic level ≤50 μg/L, and ≥80% population groundwater dependency. Statistically significant negative associations were found in each of the six models in which the exposure was limited to those who had major exposure (≥80% dependency) to low-levels of arsenic (≤50 μg/L). This is the first large ecological study of lung cancer risk from drinking water arsenic levels that specifically examined the dose-response slope for populations whose exposure was below the historical limit of ≤50 μg/L. The models for each of the three populations (total; male; female) demonstrated an association that is both negative and statistically significant.
Reloading Pupils’ Batteries: Impact of Green Spaces on Cognition and Wellbeing
Authors: Wallner Peter , Kundi Michael , Arnberger Arne , Eder Renate , Allex Brigitte , Weitensfelder Lisbeth , Hutter Hans-Peter
Published: June 2018

Cognitive functioning and academic performance of pupils depend on regular breaks from classroom work. However, it is unclear which settings during such breaks provide the best environment to restore cognitive performance and promote wellbeing of adolescent pupils. Therefore, we investigated the effects of staying in different urban green spaces during breaks. Sixty-four pupils (16–18 years old) participated in a cross-over experiment. They were placed into one of three settings (small park, larger park, forest) for one hour during a lunch break. Wellbeing was assessed four times (Nitsch scale), and a cognitive test (d2-R Test of Attention) was applied in the classrooms before and after the break. Wellbeing was almost always highest after the stay in the green spaces. However, a sustained effect was only found for the forest. Concentration performance values of the d2-R test were significantly higher after the pupils’ stay in green spaces for all sites. The highest increase of performance was found for the larger park type. In conclusion, this pilot study showed that study breaks in green spaces improved wellbeing and cognitive performance of adolescents. It also found that larger green spaces, either parks or forests, have stronger positive impacts on wellbeing and cognitive performance than small parks.
Independent and Joint Contributions of Fine Particulate Matter Exposure and Population Vulnerability to Mortality in the Detroit Metropolitan Area
Authors: Schulz Amy J. , Mentz Graciela B. , Sampson Natalie , Ward Melanie , Dvonch J. Timothy , De Majo Ricardo , Israel Barbara A. , Reyes Angela G. , Wilkins Donele
Published: June 2018

Fine particulate matter is associated with adverse health outcomes. Exposure to fine particulate matter may disproportionately affect urban communities with larger numbers of vulnerable residents. We used multilevel logistic regression models to estimate the joint effects of fine particulate matter (PM2.5) and population vulnerabilities on cardiopulmonary mortality (CPM). We estimated the health benefits of reductions in PM2.5 across census tracts in the Detroit metropolitan area with varying levels of population vulnerability, using cluster-specific odds ratios scaled to reflect PM2.5-attributable cardiopulmonary risk. PM2.5 and population vulnerability were independently associated with odds of CPM. Odds of CPM and the number of deaths attributable to PM2.5 were greatest in census tracts with both high PM2.5 exposures and population vulnerability. Reducing PM2.5 in census tracts with high PM2.5 would lead to an estimated 18% annual reduction in PM2.5-attributable CPM. Between 78–79% of those reductions in CPM would occur within census tracts with high population vulnerabilities. These health benefits of reductions in PM2.5 occurred at levels below current U.S. reference concentrations. Focusing efforts to reduce PM2.5 in the Detroit metropolitan area in census tracts with currently high levels would also lead to greater benefits for residents of census tracts with high population vulnerabilities.
A Crude 1-DNJ Extract from Home Made Bombyx Batryticatus Inhibits Diabetic Cardiomyopathy-Associated Fibrosis in db/db Mice and Reduces Protein N-Glycosylation Levels
Authors: Zhao Qing , Jia Tian Zhu , Cao Qi Chen , Tian Fang , Ying Wan Tao
Published: June 2018

The traditional Chinese drug Bombyx Batryticatus (BB), which is also named the white stiff silkworm, has been widely used in Chinese clinics for thousands of years. It is famous for its antispasmodic and blood circulation-promoting effects. Cardiomyocyte hypertrophy, interstitial cell hyperplasia, and myocardial fibrosis are closely related to the N-glycosylation of key proteins. To examine the alterations of N-glycosylation that occur in diabetic myocardium during the early stage of the disease, and to clarify the therapeutic effect of 1-Deoxynojirimycin (1-DNJ) extracted from BB, we used the db/db (diabetic) mouse model and an approach based on hydrophilic chromatography solid-phase extraction integrated with an liquid Chromatograph Mass Spectrometer (LC-MS) identification strategy to perform a site-specific N-glycosylation analysis of left ventricular cardiomyocyte proteins. Advanced glycation end products (AGEs), hydroxyproline, connective tissue growth factor (CTGF), and other serum biochemical indicators were measured with enzyme-linked immunosorbent assays (ELISA). In addition, the α-1,6-fucosylation of N-glycans was profiled with lens culinaris agglutinin (LCA) lectin blots and fluorescein isothiocyanate (FITC)-labelled lectin affinity histochemistry. The results indicated that 1-DNJ administration obviously downregulated myocardium protein N-glycosylation in db/db mice. The expression levels of serum indicators and fibrosis-related cytokines were reduced significantly by 1-DNJ in a dose-dependent manner. The glycan α-1,6-fucosylation level of the db/db mouse myocardium was elevated, and the intervention effect of 1-DNJ administration on N-glycan α-1,6-fucosylation was significant. To verify this result, the well-known transforming growth factor-β (TGF-β)/Smad2/3 pathway was selected, and core α-1,6-fucosylated TGF-β receptor II (TGFR-βII) was analysed semi-quantitatively with western blotting. The result supported the conclusions obtained from LCA lectin affinity histochemistry and lectin blot analysis. The expression level of α-1,6-fucosyltransferase (FUT8) mRNA was also detected, and the results showed that 1-DNJ administration did not cause obvious inhibitory effects on FUT8 expression. Therefore, the mechanism of 1-DNJ for relieving diabetic cardiomyopathy (DCM)-associated fibrosis can be concluded as the inhibition of N-acetylglucosamine (N-GlcNAc) formation and the reduction of substrate concentration.
Inhibition and Inactivation of Uropathogenic Escherichia coli Biofilms on Urinary Catheters by Sodium Selenite
Authors: Narayanan Amoolya , Nair Meera S. , Muyyarikkandy Muhammed S. , Amalaradjou Mary Anne
Published: June 2018

Urinary tract infections (UTI) are the most common hospital-acquired infections in humans and are caused primarily by uropathogenic Escherichia coli (UPEC). Indwelling urinary catheters become encrusted with UPEC biofilms that are resistant to common antibiotics, resulting in chronic infections. Therefore, it is important to control UPEC biofilms on catheters to reduce the risk for UTIs. This study investigated the efficacy of selenium for inhibiting and inactivating UPEC biofilms on urinary catheters. Urinary catheters were inoculated with UPEC and treated with 0 and 35 mM selenium at 37 °C for 5 days for the biofilm inhibition assay. In addition, catheters with preformed UPEC biofilms were treated with 0, 45, 60, and 85 mM selenium and incubated at 37 °C. Biofilm-associated UPEC counts on catheters were enumerated on days 0, 1, 3, and 5 of incubation. Additionally, the effect of selenium on exopolysacchride (EPS) production and expression of UPEC biofilm-associated genes was evaluated. Selenium at 35 mM concentration was effective in preventing UPEC biofilm formation on catheters compared to controls (p < 0.05). Further, this inhibitory effect was associated with a reduction in EPS production and UPEC gene expression. Moreover, at higher concentrations, selenium was effective in inactivating preformed UPEC biofilms on catheters as early as day 3 of incubation. Results suggest that selenium could be potentially used in the control of UPEC biofilms on urinary catheters.
Cellular and Molecular Mediators of Bone Metastatic Lesions
Authors: Battafarano Giulia , Rossi Michela , Marampon Francesco , Del Fattore Andrea
Published: June 2018

Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling activity, and displaying some features of bone cells. This interplay between tumor and bone cells alters the physiological bone remodeling, leading to the generation of a vicious cycle that promotes bone metastasis growth. To prevent the skeletal-related events (SRE) associated with bone metastasis, approaches to inhibit osteoclast bone resorption are reported. The bisphosphonates and Denosumab are currently used in the treatment of patients affected by bone lesions. They act to prevent or counteract the SRE, including pathologic fractures, spinal cord compression, and pain associated with bone metastasis. However, their primary effects on tumor cells still remain controversial. In this review, a description of the mechanisms leading to the onset of bone metastasis and clinical approaches to treat them are described.
ARID1B as a Potential Therapeutic Target for ARID1A-Mutant Ovarian Clear Cell Carcinoma
Authors: Sato Emi , Nakayama Kentaro , Razia Sultana , Nakamura Kohei , Ishikawa Masako , Minamoto Toshiko , Ishibashi Tomoka , Yamashita Hitomi , Iida Kouji , Kyo Satoru
Published: June 2018

AT-rich interactive domain 1A (ARID1A) and AT-rich interactive domain 1B (ARID1B) are subunits of the SWI/SNF chromatin complex. ARID1A is a tumor suppressor gene that is frequently mutated (46%) in ovarian clear cell carcinomas (OCCC). Loss of ARID1B in an ARID1A-deficient background eliminates the intact SWI/SNF complex, indicating that ARID1B is essential for the formation or stabilization of an intact SWI/SNF complex and, thus, the survival of ARID1A-mutant cancer cell lines. In this study, we investigated the clinicopathologic and prognostic relevance of ARID1B in OCCC by immunohistochemical analysis of 53 OCCC patient samples and loss-of-function experiments in OCCC cell lines. We also examined whether ARID1B could be a therapeutic target or prognostic biomarker in OCCC. siRNA-mediated knockdown of ARID1B in an ARID1A-mutant cell line significantly decreased cell growth, whereas concurrent depletion of both ARID1A and ARID1B was required to decrease wild type cell growth. In the immunohistochemical analyses, low ARID1B level was frequent in samples lacking ARID1A and was associated with shorter progression-free survival. This is the first report demonstrating that a low ARID1B level could be a marker of poor prognosis in OCCC. Moreover, the correlation between the loss of ARID1A immunoreactivity and reduced ARID1B levels indicates that ARID1B could be an attractive target for anti-cancer therapy.
A Novel Method for Determining the Attribute Weights in the Multiple Attribute Decision-Making with Neutrosophic Information through Maximizing the Generalized Single-Valued Neutrosophic Deviation
Authors: Xiong Wentao , Cheng Jing
Published: June 2018

The purpose of this paper is to investigate the weights determination in the multiple attribute decision-making (MADM) with the single valued neutrosophic information. We first introduce a generalized single-valued neutrosophic deviation measure for a group of single valued neutrosophic sets (SVNSs), and then present a novel and simple nonlinear optimization model to determine the attribute weights by maximizing the total deviation of all attribute values, whether the attribute weights are partly known or completely unknown. Compared with the existing method based on the deviation measure, the presented approach does not normalize the optimal solution and is easier to integrate the subjective and objective information about attribute weights in the neutrosophic MADM problems. Moreover, the proposed nonlinear optimization model is solved to obtain an exact and straightforward formula for determining the attribute weights if the attribute weights are completely unknown. After the weights are obtained, the neutrosophic information of each alternative is aggregated by using the single valued neutrosophic weighted average (SVNWA) operator. In what follows, all alternatives are ranked and the most preferred one(s) is easily selected according to the score function and accuracy function. Finally, an example in literature is examined to verify the effectiveness and application of the developed approach. The example is also used to demonstrate the rationality for overcoming some drawbacks of the existing approach according to the maximizing deviation method.
Multiple Congestion Points and Congestion Reaction Mechanisms for Improving DCTCP Performance in Data Center Networks
Authors: Sreekumari Prasanthi
Published: June 2018

For addressing problems such as long delays, latency fluctuations, and frequent timeouts in conventional Transmission Control Protocol (TCP) in a data center environment, Data Center TCP (DCTCP) has been proposed as a TCP replacement to satisfy the requirements of data center networks. It is gaining more popularity in academic as well as industry areas due to its performance in terms of high throughput and low latency, and is widely deployed in data centers. However, according to the recent research about the performance of DCTCP, authors have found that most times the sender’s congestion window reduces to one segment, which results in timeouts. In addition, the authors observed that the nonlinear marking mechanism of DCTCP causes severe queue oscillation, which results in low throughput. To address the above issues of DCTCP, we propose multiple congestion points using double threshold and congestion reaction using window adjustment (DT-CWA) mechanisms for improving the performance of DCTCP by reducing the number of timeouts. The results of a series of simulations in a typical data center network topology using Qualnet network simulator, the most widely used network simulator, demonstrate that the proposed window-based solution can significantly reduce the timeouts and noticeably improves the throughput compared to DCTCP under various network conditions.
A Neglected Issue in Ulcerative Colitis: Mesenteric Lymph Nodes
Authors: Sahin Abdurrahman , Artas Hakan , Eroglu Yesim , Tunc Nurettin , Oguz Gulcan , Demirel Ulvi , Poyrazoglu Orhan , Yalniz Mehmet , Bahcecioglu Ibrahim
Published: June 2018

Data evaluating the presence and characteristics of mesenteric lymph nodes (LNs) in patients with ulcerative colitis (UC) are scarce. The aim of this study is to determine the presence and characteristics of LNs in UC. The LN characteristics in computed tomography (CT), including LN dimension and attenuation, were evaluated retrospectively in 100 patients with UC (61 active and 39 inactive cases). Clinical characteristics and laboratory parameters, including CBC, biochemical analysis, erythrocyte sedimentation rate (ESR), and C reactive protein (CRP) were also compared. Mesenteric LNs were evident in all patients with UC. The attenuation and dimension of mesenteric LNs did not differ between active and inactive patients with UC. No correlation was found among patients with UC in terms of LN dimension, attenuation, ESR, CRP, leucocyte, and albumin (all with p > 0.05). The current study suggested that inflammation results in the development of mesenteric LN in UC, similar to Crohn’s disease and other inflammatory disorders.
Mechanical Properties and Wear Behavior of a Novel Composite of Acrylonitrile–Butadiene–Styrene Strengthened by Short Basalt Fiber
Authors: Abdellah Mohammed Y. , Fathi Hesham I. , Abdelhaleem Ayman M. M. , Dewidar Montasser
Published: June 2018

Polymer matrix composites (PMC) have a competitive and dominant role in a lot of industries, like aerospace and automobiles. Short basalt fiber (SBF) is used to strengthen acrylonitrile–butadiene–styrene (ABS) polymers as a composite. The composite material is fabricated using injection molding with a new technique to obtain a uniform distribution for the ABS matrix at an elevated temperature range from 140 °C to 240 °C. Four types of specimen were produced according to the mechanically mixed amounts of SBF, which were (5, 10, 15, 20) wt %. The produced material was tested for tension, hardness and impact to measure the enhancement of the mechanical properties of the ABS only and the ABS reinforced by SBF composite. Wear tests were carried out using a pin on disc at a velocity of 57.5 m/s at three normal loads of 5, 10 and 15 kN. Tensile strength increased with up to 5 wt % of SBF, then decreased with an increasing amount of SBF reinforcement, while surface hardness increased with increasing SBF. The impact strength was found to degrade with the whole increment of SBF. Wear resistance increased with the increasing SBF reinforcement amount at all applied normal loads.
The Effects of Uniquely-Processed Titanium on Balance and Walking Performance in Healthy Older Adults
Authors: Black Melissa J. , Lucero Adam A. , Fink Philip W. , Stoner Lee , Shultz Sarah P. , Lark Sally D. , Rowlands David S.
Published: June 2018

The increased risk of falls associated with advancing age has increased demand for methods to improve balance and mobility. The primary purpose of the study was to determine whether wearing Aqua Titan-treated stockings could improve balance and walking performance in an older population; secondary was to elucidate the mechanisms. In a randomized, double-blind crossover, 16 healthy older adults (age, 67.9 ± 4.2 years; BMI, 24.8 ± 3.1 kg/m2) performed two 4-day trials composed of baseline measures and fatiguing exercise on Day 1, with recovery measures at 14, 38 and 62 h post-exercise, wearing Aqua Titan and control stockings. Balance, walking performance, triceps surae stretch reflex, ankle range of motion and gastrocnemius muscle microvascular perfusion, blood flow and oxygen consumption were measured at baseline and during recovery. Aqua Titan had no effect on the microvascular parameters, but increased total ankle range of motion at 38 h (2.4°; 95% CI ± 1.8°) and 62 h (2.7°; ±1.7°), contributed to by increases in dorsiflexion and plantar flexion. There was decreasing persistence in the medial-lateral center of pressure movement at 38 h (q = 0, −0.0635 ± 0.0455), compared to control stockings. Aqua Titan garments hold potential for improving balance and mobility in older adults in the days following a bout of fatiguing exercise. The proposed mechanisms associated with enhanced sensory feedback require further exploration.
Dental Resin Cements—The Influence of Water Sorption on Contraction Stress Changes and Hydroscopic Expansion
Authors: Sokolowski Grzegorz , Szczesio Agata , Bociong Kinga , Kaluzinska Karolina , Lapinska Barbara , Sokolowski Jerzy , Domarecka Monika , Lukomska-Szymanska Monika
Published: June 2018

Resin matrix dental materials undergo contraction and expansion changes due to polymerization and water absorption. Both phenomena deform resin-dentin bonding and influence the stress state in restored tooth structure in two opposite directions. The study tested three composite resin cements (Cement-It, NX3, Variolink Esthetic DC), three adhesive resin cements (Estecem, Multilink Automix, Panavia 2.0), and seven self-adhesive resin cements (Breeze, Calibra Universal, MaxCem Elite Chroma, Panavia SA Cement Plus, RelyX U200, SmartCem 2, and SpeedCEM Plus). The stress generated at the restoration-tooth interface during water immersion was evaluated. The shrinkage stress was measured immediately after curing and after 0.5 h, 24 h, 72 h, 96 h, 168 h, 240 h, 336 h, 504 h, 672 h, and 1344 h by means of photoelastic study. Water sorption and solubility were also studied. All tested materials during polymerization generated shrinkage stress ranging from 4.8 MPa up to 15.1 MPa. The decrease in shrinkage strain (not less than 57%) was observed after water storage (56 days). Self-adhesive cements, i.e., MaxCem Elite Chroma, SpeedCem Plus, Panavia SA Plus, and Breeze exhibited high values of water expansion stress (from 0 up to almost 7 MPa). Among other tested materials only composite resin cement Cement It and adhesive resin cement Panavia 2.0 showed water expansion stress (1.6 and 4.8, respectively). The changes in stress value (decrease in contraction stress or built up of hydroscopic expansion) in time were material-dependent.
The Effect of Buffer Types on the In0.82Ga0.18As Epitaxial Layer Grown on an InP (100) Substrate
Authors: Zhang Min , Guo Zuoxing , Zhao Liang , Yang Shen , Zhao Lei
Published: June 2018

In0.82Ga0.18As epitaxial layers were grown on InP (100) substrates at 530 °C by a low-pressure metalorganic chemical vapor deposition (LP-MOCVD) technique. The effects of different buffer structures, such as a single buffer layer, compositionally graded buffer layers, and superlattice buffer layers, on the crystalline quality and property were investigated. Double-crystal X-ray diffraction (DC-XRD) measurement, Raman scattering spectrum, and Hall measurements were used to evaluate the crystalline quality and electrical property. Scanning electron microscope (SEM), atomic force microscope (AFM), and transmission electron microscope (TEM) were used to characterize the surface morphology and microstructure, respectively. Compared with the In0.82Ga0.18As epitaxial layer directly grown on an InP substrate, the quality of the sample is not obviously improved by using a single In0.82Ga0.18As buffer layer. By introducing the graded InxGa1−xAs buffer layers, it was found that the dislocation density in the epitaxial layer significantly decreased and the surface quality improved remarkably. In addition, the number of dislocations in the epitaxial layer greatly decreased under the combined action of multi-potential wells and potential barriers by the introduction of a In0.82Ga0.18As/In0.82Al0.18As superlattice buffer. However, the surface subsequently roughened, which may be explained by surface undulation.