bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural population movement and COVID-19: data from Russia
Authors: Nusratullin Ilmir , Drozdov Igor , Ermakov Alexei , Koksharova Elena , Mashchenko Maya
Published: January 2022

The COVID-19 pandemic is highly infectious, so it paralyzed the health systems of many countries causing a high mortality rate. Official data on COVID-19 deaths at many sites are questioned, and the figures are considered several times higher than official data. In this sense, the objective of the study was to determine the impact of the COVID-19 pandemic on the natural movement of the population and, in addition, to evaluate the real mortality rate from COVID-19 in Russia from the construction of predictive mortality models. The study used data from the World Health Organization and the Statistical Service of the Federal State of Russia; se used linear and polynomial models to construct mortality models. The study revealed an underestimation of the official COVID-19 death rate by 2.4 to 6.8 times, depending on the data source. There was a sharp increase in mortality in Russia in 2020 among people over 50 years of age, and with the increase in age, mortality increased. The main reasons for the sharp increase in mortality were coronary heart disease, cerebrovascular diseases, and respiratory diseases, among others.
Política sexual, activismo conservador y redes sociodigitales
Authors:   CONICET.Universidad Nacional de Córdoba, Sgró Ruata Candelaria
Published: January 2022

Consideramos que la transformación de los ordenes heteronormativos implica comprender también las maneras en que se despliega la resistencia a estas transformaciones. El activismo en oposición a las demandas de movimientos feministas y por la diversidad sexual no es nuevo pero presenta renovadas facetas que es necesario explorar. Una de ellas es su presencia y articulación en las redes sociodigitales. Seleccionamos los debates parlamentarios sucedidos en Argentina sobre la ley de Interrupción Voluntaria del embarazo (2018) y ley de matrimonio igualitario (2010) como momentos clave para la observación de las prácticas desplegadas en los entornos virtuales por los sectores en oposición a los derechos sexuales y reproductivos. A partir del seguimiento de páginas en Facebook, twitter y sitios web conformamos un corpus documental. Con esta base, abrimos lecturas analíticas que se desprenden de la observación coyuntural pero la exceden y las organizamos en dimensiones emergentes: insistencias de sentido, contradiscursos y disputas por la captura del sentido. Estas dimensiones nos permiten caracterizar esta renovada faceta de la movilización conservadora en el campo de la sexualidad que denominamos provisoriamente como ciberactivismo conservador.
ANALISIS FAKTOR YANG BERPENGARUH TERHADAP PENGUNGKAPAN LAPORAN PERUSAHAAN YANG BERBASIS DARING ATAU WEB PADA PT. JASA MARGA KUALANAMU TOL
Authors: Asmalia Nur , Sumekar Aried
Published: January 2022

Preparation of financial reports using this online or web method aims to make iteasier for employees to make financial reports using the Internet or web media. Theinternet is widely used by various groups of people to facilitate a job, be it a job inthe financial or non-financial fields. The internet also helps to disseminateinformation and communication of a company, especially in the financial sector, sothat outside investors can find out about the company's financial developments inan effective and efficient manner. The media for delivering this information isknown as IFR (Internet Financial Reporting). The method in preparing thesefinancial statements is the method of profitability, leverage, and liquidity. This datacollection method is by doing a 7-day risert at the company PT. JasamargaKualanamu Tol as well as data sources from libraries and employees at thecompany through interviews. This online financial report preparation can be saidto be successful if the investors out there are enthusiastic about the company'sfinancial statements.
ANALISIS PENERAPAN, PEMAHAMAN DAN KEEFEKTIFAN E-FAKTUR DALAM PELAPORAN SPT MASA PAJAK PERTAMBAHAN NILAI ( STUDI KASUS DI PT. POMONA INDAH PERMAI )
Authors: Wilda Wilda , Nurhayati Nurhayati
Published: January 2022

E-faktur is an electronic tax invoice made by the Directorate General of Taxes tofacilitate PKP in making electronic tax invoices and reduce manipulation of taxinvoices or create fictitious tax invoices that can affect VAT that must be borne. Theapplication of Electronic Tax Invoice is regulated in Regulation of the DirectorGeneral of Tax PER-16 / PJ / 2014, which was carried out in stages starting onJuly 1, 2014, July 1, 2015, and finally July 1, 2016. The purpose of this study wasto determine the making of electronic tax invoices through e -Faktur and to find outthe application of VAT Period SPT reporting at PT. Pomona Indah Permai. Thistype of research used in this study is a qualitative descriptive analysis approach.The results showed that in the application of e-Faktur PT. Indah Permai hasimplemented e-Faktur since September 2015, the application of e-Fakturs inmaking tax invoices has been going well, PT. Pomona Indah Permai hasunderstood the application of e-Foice applications, and the application of e-Foiceapplications in the making and reporting of the VAT Period has been runningeffectively in accordance with the regulations of the Directorate General of TaxPER-16 / PJ / 2014. However, in the VAT Period SPT reporting the company usese-filing and has been running well even though the company reports its taxobligations right at the end of the VAT Period SPT reporting period.
Critical Realism for Health and Illness Research
Authors: Alderson Priscilla
Published: January 2022

Critical realism helps researchers to extend and clarify their analyses. This original text draws on international examples of health and illness research across the life course, from small studies to large trials, to show how versatile critical realism can be in validating research and connecting it to policy and practice.
Radical Empathy
Authors: Givens Terri E.
Published: January 2022

Renowned political scientist Terri E. Givens calls for 'radical empathy' in bridging racial divides to understand the origins of our biases, including internalized oppression. Deftly weaving together her own experiences with the political, she offers practical steps to call out racism and bring about radical social change.
Data Lives
Authors: Kitchin Rob
Published: January 2022

Rob Kitchin explores how data-driven technologies have become essential to society, government and the economy. Blending scholarly analysis, biography and fiction, he demonstrates how data influence our daily lives.
THE EROSION OF THE SALDUZ DOCTRINE IN THE CASES OF IBRAHIM AND OTHERS V. THE UNITED KINGDOM AND BEUZE V. BELGIUM
Authors:   Independent researcher, H. Avdić Faruk
Published: January 2022

The so-called Salduz doctrine that concerns the right to a fair trial and the right to the defense attorney emerged from the case of Salduz v. Turkey, decided on the part of the European Court of Human Rights where the Grand Chamber found the violation of Article 6, paragraph 3(c) of the Convention for the Protection of Human Rights and Fundamental Freedoms. In this connection, the aim of this paper is twofold. In the first place, the paper aims to demonstrate how the European Court of Human Rights has overturned the two main tenents of the so-called Salduz doctrine derived from its landmark case of Salduz v. Turkey in its later Judgments delivered in the case of Ibrahim and Others v. the United Kingdom and the case of Beuze v. Belgium. The two tenets derived from the Salduz doctrine being examined in the paper are the right to access to the defense attorney as a rule during pre-trial proceedings and the absolute exclusionary rule. In the second place, the paper aims to offer a critique of the standard of compelling reasons employed in the Ibrahim Judgment. In order to achieve its aim, this paper primarily analyses the jurisprudence of the European Human Court of Human Rights in the cases of Salduz v. Turkey, Ibrahim and Others v. the United Kingdom, and Beuze v. Belgium. Besides, the paper also touches upon other judgments of the European Court of Human Rights related to its subject. The paper in question, therefore, primarily relies on the case-law method in achieving its aims. The paper concludes that in overturning the Salduz doctrine in relation to aspects examined in the paper, the European Court of Human Rights has exacerbated the legal standing of the person against whom criminal proceedings are being conducted.
Pengaruh Strategi Positioning terhadap Keputusan Pembelian Produk Asuransi Jiwasraya
Authors: Sindi Sindi , Aslami Nuri
Published: January 2022

The purpose of this study is to identify and analyze the effect of product positioning strategy, price and service on consumer purchasing decisions on life insurance. This research is a library research. This research is a type of research that tries to collect data from literature studies. The first step of this research is to collect and study data from the same research by previous researchers . The results of this study indicate that products, prices and services have a significant effect on consumers' purchasing decisions on life insurance. The positioning strategy in making the decision to purchase life insurance products is positive. The company determines its target market, which includes all consumers as a whole. Meanwhile, the company's positioning strategy always prioritizes the interests of consumers, affordable product prices, and provides benefits.

Keywords: Positioning strategy, Purchase decision, Influence
ÇOCUK SAĞLIĞI VE HASTALIKLARI HEMŞİRELİĞİ DERSİNİ ALAN HEMŞİRELİK ÖĞRENCİLERİNİN KAVRAM HARİTASINA İLİŞKİN ALGILARI: BİR METAFOR ÇALIŞMASI
Authors: TURAN Fatma Dilek
Published: January 2022

Araştırma ile Çocuk Sağlığı ve Hastalıkları Hemşireliği dersini alan hemşirelik öğrencilerinin kavram haritasına ilişkin algılarının metafor aracılığıyla ortaya çıkarılması amaçlanmıştır. Araştırmada nitel araştırma yöntemlerinden olgu bilim deseni kullanılmıştır. Araştırmanın örneklemini kavram haritasına dayalı eğitim alan ilk ve tek grup olan, 2020-2021 Eğitim Öğretim Yılı Bahar Yarıyılında Çocuk Sağlığı ve Hastalıkları Hemşireliği Dersini alan hemşirelik öğrencileri oluşturmuştur. Dersi alan 103 öğrenciden 53’ünün katılımı ile araştırma tamamlanmıştır. Veriler Öğrenci Bilgi Formu ve kavram haritası algılarını sorgulayan, “Kavram Haritası… gibidir, çünkü…” metafor cümlesi kullanılarak toplanmıştır. Veriler içerik analiz tekniğiyle çözümlenmiştir. Öğrencilerinin %75,47’si kız, yaş ortalaması 22,21±3,23 yıldır. Öğrenciler “Kavram Haritası” algısına yönelik 32 metafor oluşturmuşlardır. Frekansı en yüksek metaforlar “yapboz (f=7)”, “puzzle (f=6), “örümcek ağı (f=4) ve “soy ağacı (f=3)” dır. Tüm metaforlar yedi kategoride toplanmıştır. Bu kategoriler; “bütünlük”, “yol gösterme”, “bağlantı”, “başlangıç”, “merkez”, “kontrol” ve “alışkanlık/besin” kategorileridir. Araştırmanın örneklemini oluşturan öğrencilerin ağırlıklı olarak “kavram haritası”na ilişkin olumlu metaforik algılara sahip oldukları belirlenmiştir.
Habitat use of common dolphin (Delphinus sp.) in the Mochima National Park, Sucre, Venezuela.
Authors: Molero-Lizarraga Alimar , Barreto Guillermo , Cobarrubia-Russo Sergio
Published: January 2022

In Venezuela, common dolphin (Delphinus sp.) is considered the cetacean with the highest incidence. Studies in the region indicate a possible isolated coastal population so called Venezuelan stock   settled mainly in the northeast of the country.  . The objective of this study is to describe the habitat use of common dolphin in the Mochima National Park (MNP), a protected area with a high and growing anthropic pressure. Seventy surveys were carried out, with predefined survey route, from September 2009 to August 2010. Each group sighted was monitored while possible to a maximum of 30min.. During this time we registered location (Latitude-longitude), behaviour, group size and composition every 5min. Additionally, environmental variables were assessed from the sight location in a nautical chart. The study area was divided into a grid (cell: 500 x 500m) and the Coefficient of Area Use (CAU) was calculated for each cell. The proportion of the total observation time where the common dolphin displayed behaviours into the areas being used was estimated. A logistic regression model was applied to identify the variables that better explained usage pattern. In 55h of observation, 111 groups were recorded. The common dolphin used the habitat differentially, showing preferences for shallow areas  near to the coast. Areas of greatest intensity of use were Tigrillo inlet and the northeast of the Caracas Islands. The probability of presence of dolphins decreased with depth and distance to the coast. Common dolphin invested more time in feeding and socializing activities. Behaviours were significantly dependent of season, group size, composition, depth and distance to the coast. Finally, these data on habitat use and behaviour allow the identification of priority habitats. Throughout the year, the MNP provided areas for refuge, feeding and resting. , It is therefore imperative to promote management and conservation policies that prevent the negative impacts of the increasing   tourism and fishing activities we observed in this Park.
The Syntax of Unreliable Narrators’ I-Utterances in ‘Gone Girl’ by G. Flynn
Authors: Hnatkovska Olena
Published: January 2022

Unreliable narration research raises the problem of truthful information presented in fiction, which is for the most part made up. However, the truth in the fictional world is what the reader believes to be true. Therefore, deliberate deluding or confusing the reader by an untrustworthy character creates an additional fictional layer consisting of false facts. This represents the contradiction between the imaginary and the fake, the latter being untrue in terms of fiction. The paper examines how the author of the best-selling novel Gone Girl realizes her intention of deceiving or misleading the readers on the syntactic level of speech of the two main characters who are unreliable narrators. The analysis of sentence structure variety, average sentence length and syntactic stylistic peculiarities of I-utterances aims at ascertaining whether these devices and their frequency indicate that the author gives the readers a hint at the unreliability of the narration. Sentence complexity and types of clauses in composite sentences are also taken into consideration as possible signs of unreliability. As one main character is male and the other is female, the quantitative analysis of syntactic features is carried out separately to detect gender differences.
Audiovisual Translation in Romanian TV News Programmes
Authors: Sinu Raluca
Published: January 2022

This paper proposes an investigation into the place of audiovisual translation in Romanian television news programmes. Although news translation has attracted a lot of attention in recent years, the same cannot be said about the various forms of audiovisual translation used in news programmes, which might range from interlingual subtitling and voice-over to media interpreting and signed language interpreting. The present paper attempts to highlight the contexts in which these types of translation are used in Romanian broadcast news, their features and functions. We will begin by discussing the concept of news translation and contrast it with audiovisual translation in the news. This will be followed by an overview and short description of the different forms of audiovisual translation encountered in the news. Based on this framework, we will then conduct a small-scale survey of several news broadcasts of the Romanian public television service in order to identify the situations in which a particular type of audiovisual translation tends to be used, as well as the reasons for resorting to it and ensuing results.
Mecánica de materiales 1
Authors: Rodríguez Mijangos Ricardo , Rodríguez Soria Abelardo , Bastién Montoya Gustavo Mauricio , Falcón Hernández Nicolás
Published: January 2022

Este volumen está dirigido a estudiantes de la licenciatura en física, ingeniería, o a interesados en la mecánica de materiales. El contenido aborda principalmente el estudio de las fuerzas internas de cables, resortes y varillas, así como el problema de tracción simple y teoría general del esfuerzo. Dentro de cada capítulo se mencionan ejemplos de problemas resueltos y problemas a ejercitar.
Paradigmas emergentes en la administración
Authors: De la Rosa Leal María Eugenia , Gastélum Franco Rosa Laura , Ballesteros Grijalva Mónica , Hernández García Patricia , Recio Reyes Ramón Gerardo , Gómez Sánchez David , Balderas Huerta María Edith , Mul Encalada Jennifer , Ojeda López Ruth Noemí , Sánchez Limón Mónica Lorena , Montiel Méndez Oscar Javier , Cruz Aldana Eduardo , Ortega Reyes Antonio Oswaldo , Garnica González Jaime , Carmona Eduardo Alejandro , Chávez Chairez Rubén , Palomo Juárez Sergio Humberto , López Gama Héctor , González Ortiz Jorge Horacio
Published: January 2022

La administración como disciplina de los negocios permite visualizar y ordenar la operación y los recursos para el logro de las metas, el crecimiento más allá de las expectativas y la colocación en el mercado. En todo esto, es necesaria una apertura a la visión de desarrollo y una administración científica que atienda todos los aspectos funcionales de una organización, sea ésta del tamaño que fuere, entendiendo que en la medida que el mercado es mayor, la complejidad de la administración también lo será. En este libro la posición de cada uno de los capítulos, desde el enfoque de investigadores pertenecientes a la Academia de Ciencias Administrativas de México, fue enfrentar y analizar nuevas situaciones de los negocios a partir de un estudio particular emergente, con la intención de crear nuevos conocimientos de una realidad nacional a la par de una administración clásica. La obra presenta siete capítulos distribuidos en tres secciones: Estudios regionales, Análisis teóricos e Instituciones de Educación Superior, todos contextualizados en regiones y actividades diferentes, con un objetivo común: entender y atender las necesidades de operación de distintas organizaciones. La sección de Estudios regionales revisa en tres trabajos las líneas de Sustentabilidad y Desarrollo, la satisfacción laboral y las implicaciones de las Tecnologías de Información. En la sección de Análisis teóricos, con dos trabajos, se presentan estudios del Startup y la versión gerencial. En la última sección, Instituciones de Educación Superior, dos trabajos estudian y analizan el clima organizacional y los Factores sociales en el rendimiento. En todos los capítulos el abordaje es deductivo con una metodología científica, cuidando las contradicciones y vacíos en los estudios desarrollados, delimitando y definiendo con claridad el objeto de estudio y el alcance del paradigma emergente. Este libro es un trabajo colaborativo para dar respuesta a una realidad cimentada en el conocimiento de las ciencias sociales-administrativas.
Gluten-related immunogenic peptides in stool as means to monitor compliance with gluten-free diet in children with newly dia gnosed coeliac disease
Authors: Vyhnánek Radim , Khaznadar Ziad , Vyhnánek Roman , Paulík Milan
Published: January 2022

Objectives and study: To compare the values of gluten-related immunogenic peptides (GIP) in stool and anti-tissue transglutaminase IgA antibodies (anti-tTG IgA) in blood in children newly diagnosed with coeliac disease (CD). Methods: All children (2–15 y) newly diagnosed with CD between May 2018 and May 2020 at our clinic who complied with the inclusion criteria were invited to join the prospective study. During workup for CD, a stool sample to measure GIP was taken together with a blood sample to measure anti-tTG IgA. All newly diagnosed children were invited 4 months later for a check-up. Children and their caregivers were asked about known non-compliance with the gluten-free diet (GFD), a blood sample was taken to measure the anti-tTG IgA, and a stool sample was collected to measure GIP. Blood was evaluated for anti-tTG IgA by ELISA, and the stool was tested by quantitative Sandwich ELISA designed to detect and quantify GIP using the G12 antibody. Values of GIP and anti-tTG IgA were compared in terms of their relation to the upper limit of normal (ULN) of the particular method. Results: 29 children (18 girls) were enrolled in the study. The values of GIP in stool at the time of diagnosis were above the ULN (0.15 µg/g) in all children. Average 4.21, median 3.29, standard deviation (SD) 3.7. After the four months, all but three (89.7%) had values of GIP in the reference range. Average 0.29, median 0.12, SD 0.73. Similarly, anti-tTG IgA values were above the ULN (9.9 U/mL) at the time of diagnosis in all children. Average 164, median 195, SD 49. Although the anti-tTG IgA levels were lower at check-up in all but one child, only 10 (34.5%) showed values within the normal range, with an average of 27.9, median 12.0, and SD 38.9. All children declared strict adherence to GFD. Discussion: Using the GIP concentration in stool, adherence to GFD in our cohort of children is very good, better than that described in literature. Conclusion: Measuring GIP in stool could prove a more sensitive indicator of adherence to GFD in the early months after the diagnosis of CD when anti-tTG IgA are still elevated above the ULN due to their well-described gradual decrease after GFD initiation.
La perception des inégalités et la promotion de la justice sociale par de futur-es enseignant-es issu-es de la migration
Authors: Delévaux Olivier
Published: January 2022

Les constats liés à la surreprésentation des élèves issu-es de la migration dans les filières de formation à exigences élémentaires ou dans les structures de l’enseignement spécialisé montrent que, malgré la mise en évidence depuis de nombreuses années des mécanismes de discrimination systémique opérant au sein du système scolaire, l’évolution en termes de réussite éducative n’est pas satisfaisante. Notre recherche qualitative s’appuie sur 25 entretiens semi-dirigés réalisés auprès de futur-es enseignant-es primaires issu-es de la migration de la Haute école pédagogique du canton de Vaud à Lausanne. Elle vise à mettre en évidence des expériences d’injustices dans leur propre parcours, mais également leurs observations de discriminations liées à l’origine des élèves dans le cadre des stages et à évoquer des pistes visant un renforcement de la justice sociale au sein de l’école. Les résultats montrent que la quasi-totalité des personnes interrogées a été confrontée personnellement à des difficultés en lien avec leur histoire migratoire. Leurs parcours scolaires et de formation sont souvent parsemés d’embûches, peu linéaires, et parfois marqués par des injustices manifestes. Ils sont également souvent témoins, lors de leurs stages, de manifestations de discriminations visant les élèves issu-es de la migration. Les pistes évoquées impliquent les enseignant-es et s’orientent vers les élèves, mais surtout vers leurs familles.
Teachers’ critical reflection: what are the practices for social justice in education?
Authors: Koubeissy Rola , Audet Genevieve
Published: January 2022

This article explores teachers’ participation in the school’s social justice system through the lens of the critical multicultural approach (May & Sleeter, 2010; May, 2000; 2003). Based on a research project about reconstruction and the theorization of teachers’ stories of practice (Desgagné, 2005) in a multiethnic context, data was collected from teachers in highly multiethnic primary schools in Québec. They were asked to narrate a story about a problem or an event with an immigrant or refugee student in their class. Four of these stories have been selected for this article. Our aim was to analyze the teachers’ cultural responses and their perception of their roles in supporting their students. Our analysis shows that although these teachers tend to make changes to their students’ reality, they cannot escape or contest “alone” the norms of an academic, societal and political system that governs its power relationships and privileges, its dominant norms and values.
Les apports de la perspective fraserienne pour comprendre les enjeux de justice sociale en éducation
Authors: Bauer Stéphanie , Radhouane Myriam
Published: January 2022

Le concept de justice sociale semble de plus en plus prégnant dans les sciences sociales francophones. Dans cette contribution, nous avons choisi de mobiliser la théorie fraserienne relative à ce concept afin de mettre en perspective la question de la justice sociale en éducation. Nancy Fraser, en développant une définition ternaire du concept, nous permet de porter un regard sur les enjeux de distribution, de reconnaissance, mais aussi de représentation dans l’école. Ce travail théorique nous permet de mettre en lumière le potentiel de l’usage du concept de justice sociale en éducation, les interdépendances entre ses différentes dimensions, et ainsi de proposer un regard critique et complexifié sur les différentes politiques et actions éducatives visant à rendre l’école plus juste. En outre, nous étendons également notre réflexion à l’importance de la pensée critique comme outil du développement de la justice sociale dans les différentes strates des systèmes éducatifs.
Automation of an automobile internal combustion engine bench calibration tests
Authors: Evdonin E. S. , Dushkin P. V. , Kuzmin A. I. , Khovrenok S. S. , Kremnev V. V.
Published: January 2022

Introduction(problemstatement and relevance).The article presents the work on the automation of an internal combustion engine (ICE) calibration tests results on a motor stand. The relevance of the article is due to the high labor intensity of such tests, the complexity of documentation and decisionmaking based on the results of the work.

Purposeof the study. This work is part of a comprehensive methodology, the purpose of which is to reduce the duration of tests and improve the calibration results quality of the vehicle’s power plant. The entire methodology description as a whole is also given in the publication.

Methodology and research methods.The achievement of this goal is ensured with the help of special systems – INCA-FLOW (test automation) and ASCMO (processing results and optimization), produced by Bosch/ETAS. The approbation of the technique was carried out on a motor stand in the MADI training box in relation to the problem of forming an ignition timing map.

Scientiﬁc novelty and results.As a result of the methodology application, a 4.8 times reduction in the motor tests duration takes place if 2 people work in manual mode at the test bench without interruption.

At the same time, the variance of the adequacy ofSadof the torque empirical modelMkturned out to be, on average, 1.5 times less if the model was built according to the automated tests results. The obtained data indicated an improvement in the quality of measurements in the transition to automated test methods.

From a scientiﬁc point of view, the most original part of the work is the application of the “Gaussian process” method to build empirical models. This method provides more accurate results than, for example, the traditional method of least squares.

Thepracticalsigniﬁcanceof the work lies in the ability to considerably reduce routine actions on a motor stand, and the additional time spent on developing and testing a test scenario (program) is compensated for by the fact that scenario models can be used in the future for other similar tests. The proposed methodology makes it possible to cover a signiﬁcant part of the internal combustion engine calibration tests. For example, you can apply it if you possess the preliminary information about the test object (basing on which you can draw up an experiment plan) and the engine is to be prepared either for a car road tests or tests under special conditions.
KHẢO SÁT TÌNH HÌNH MẮC BỆNH LÝ MŨI XOANG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN KHẢ NĂNG TIẾP CẬN CÁC DỊCH VỤ KHÁM CHỮA BỆNH BỆNH LÝ VÙNG MŨI XOANG Ở BỆNH NHÂN TỪ 18 TUỔI TRỞ LÊN TẠI HUYỆN MỸ TÚ, TỈNH SÓC TRĂNG NĂM 2020 - 2021
Authors: Triều Việt Nguyễn , Sà Kinh Triệu
Published: January 2022

Mục tiêu: Xác định tỷ lệ mắc các bệnh lý mũi xoang và khả năng tiếp cận các dịch vụ khám chữa bệnh ở bệnh nhân từ 18 tuổi trở lên mắc bệnh lý vùng mũi xoang tại Huyện Mỹ Tú, Tỉnh Sóc Trăng, năm 2020 -2021. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 640 người dân từ 18 tuổi trở lên tại Huyện Mỹ Tú, Tỉnh Sóc Trăng từ tháng 5-12/2020. Kết quả: Tỷ lệ mắc bệnh lý vùng mũi xoang là 27,5%. Trong đó, bệnh viêm mũi dị ứng là 44,9%, viêm mũi xoang cấp tính là 20,5%, viêm mũi xoang mạn tính là 33,5%, Polype mũi là 1,1%. 75% ở mức độ nhẹ. . Tỷ lệ đối tượng nghiên cứu tiếp cận dịch vụ khám chữa bệnh các bệnh lý mũi xoang là 77,3%. Yếu tố liên quan đến tỷ lệ tiếp cận các dịch vụ khám chữa bệnh của người dân bao gồm: Nơi ở, khoảng cách đến CSYT gần nhất, mức độ mắc bệnh, loại hình bệnh mũi xoang. Kết luận: Tỷ lệ mắc bệnh mũi xoang tại huyện Mỹ Tú, tỉnh Sóc Trăng khá cao chiếm 27.5% số đối tượng tham gia nghiên cứu. Khả năng tiếp cận các dịch vụ khám chữa bệnh liên quan đến nơi ở, khoảng cách đến cơ sở y tế gần nhất, mức độ mắc bệnh, loại hình bệnh mũi xoang.
ĐẶC ĐIỂM LÂM SÀNG HÀNH VI TỰ SÁT Ở BỆNH NHÂN RỐI LOẠN CẢM XÚC LƯỠNG CỰC
Authors: Quyết Thắng Trần , Văn Tuấn Nguyễn
Published: January 2022

Đặt vấn đề: Rối loạn cảm xúc lưỡng cực là bệnh nội sinh, mạn tính, ngay cả khi điều trị thì khoảng 37% bệnh nhân tái phát thành trầm cảm hoặc hưng cảm trong vòng 1 năm và 60% tái phát trong vòng 2 năm, là một trong số mười nguyên nhân hàng đầu gây ra khuyết tật trên toàn thế giới năm 1990. Trên thế giới đã có nhiều nghiên cứu về tự sát và tự sát ở bệnh nhân trầm cảm nhưng chưa có nhiều nghiên cứu về tự sát trên rối loạn cảm xúc lưỡng cực. Vì vậy để phục vụ thực hành lâm sàng và phát hiện sớm để kịp thời điều trị, từ đó giúp giảm gánh nặng chăm sóc, chúng tôi tiến hành nghiên cứu “Đặc điểm lâm sàng hành vi tự sát ở bệnh nhân rối loạn cảm xúc lưỡng cực” với mục tiêu: Mô tả đặc điểm lâm sàng tự sát ở bệnh nhân rối loạn cảm xúc lưỡng cực. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang 39 bệnh nhân rối loạn cảm xúc lưỡng cực có tự sát trong 102 bệnh nhân được chẩn đoán rối loạn lưỡng cực được điều trị tại bệnh viện Tâm thần Hà Nội, bệnh viện Tâm thần Mỹ Đức, Viện sức khỏe Tâm thần Quốc gia từ tháng 12/2020 đến tháng 8/2021. Kết quả: có 38,223% bệnh nhân có tự sát, trong đó tỷ lệ bệnh nhân nam chiếm 64,1%, bệnh nhân nữ chiếm 35,9%. Trong nhóm tự sát bệnh nhân thất nghiệp chiếm 69,23%, tỷ lệ tiền sử bệnh lý tâm thần của gia đình là 15,38%, độ tuổi trung bình 41,97 ± 13,31, thời gian mắc bệnh trung bình 12,31 ± 9,14, tuổi khởi phát trung bình 29,67 ± 11,23, giai đoạn hưng cảm chiếm 84,62%, 100% không điều trị hoặc điều trị không đều, có ý tưởng tự sát bệnh nhân giai đoạn hưng cảm chiếm 84,62%, trầm cảm chiếm 15,38%, 48,72% xuất hiện ý tưởng tự sát cả ngày và đêm, 7,69% xuất hiện vào ban đêm, Thang điểm Miller trung bình của nhóm bệnh nhân ý tưởng tự sát là 18,26 ± 9,514.
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ PHẪU THUẬT U HẬU NHÃN CẦU TẠI BỆNH VIỆN K
Authors: Đức Liên Nguyễn , Văn Luyện Hoàng
Published: January 2022

Mục tiêu: Đánh giá kết quả điều trị phẫu thuật u hậu nhãn cầu. Đối tượng và phương pháp nghiên cứu: nghiên cứu cắt ngang, hồi cứu và tiến cứu, gồm 30 bệnh nhân u hậu nhãn cầu được chẩn đoán, điều trị phẫu thuật tại khoa Ngoại Thần Kinh - bệnh viện K từ 01/2017 đến 06/2021. Kết quả: Tỷ lệ nam/nữ là 1,14/1; tuổi trung bình là 37,8 ± 22,6 (4 – 71 tuổi). Triệu chứng lâm sàng thường hay gặp nhất là lồi mắt (90%), đau mắt (86,7%), giảm thị lực (76,7%). Khối u lành tính (43,4%), u ác tính (56,7%); trong đó hay gặp nhất là u màng não (23,3%), sarcoma cơ vân thể bào thai (13,3%), carcinoma không sừng hóa  xâm nhập (10%). Kết quả lấy toàn bộ u và gần toàn bộ là 46,7% và 33,3%. Không có trường hợp nào tử vong, chảy máu do phẫu thuật. Kết quả khám lại hiện tại: Có 8/30 (26,7%) bệnh nhân tử vong, trung bình 9,0±4,3 tháng, các loại giải phẫu bệnh (Carcinom không sừng hóa xâm nhập; Sarcoma (cơ vân thể hốc, xương, cơ vân thể bào thai, sụn trung mô, xơ bì lồi); Carcinom biểu bì nhày độ cao). U tiến triển, tái phát: có 6/30 (20%), trung bình 9,0 ± 4,3 tháng, các loại giải phẫu bệnh (Hemangiopericytome malin độ III, Sarcoma (cơ vân thể hốc, xương, cơ vân thể bào thai, xơ bì lồi), Carcinom không sừng hóa xâm nhập). Còn u tồn dư, u lành tính, không tiến triển: có 9/30 (30%), trung bình 15,67 ± 12,7 tháng, các loại giải phẫu bệnh (u màng não, loạn sản xơ xương, u mạch thể tĩnh mạch, giả u – viêm mạn). Không còn u, u lành tính: có 4/30 (13,3%), trung bình 19,25 ± 8,9 tháng, các loại giải phẫu bệnh (Swhannoma, u màng não). Kết luận: Phẫu thuật là phương pháp hiệu quả để chẩn đoán và điều trị các u hậu nhãn cầu. Tỉ lệ lấy toàn bộ u và gần toàn bộ là 46,7% và 33,3%, tỉ lệ biến chứng sau mổ thấp (Có 4 ca chiếm 13,33% trường hợp nhiễm trùng tại chỗ hốc mắt. Không có biến chứng chảy máu nội nhãn hay máu tụ nội sọ, rò dịch não tủy, tràn khí).
ĐẶC ĐIỂM LÂM SÀNG VÀ MỨC ĐỘ NẶNG CỦA TỔN THƯƠNG PHỔI TRÊN X QUANG NGỰC Ở BỆNH NHÂN NHẬP VIỆN DO COVID-19
Authors: Văn Sỹ Hoàng , Minh Kha Nguyễn , Thanh Phong Nguyễn , Nghĩa Huỳnh , Phước Truyền Lê , Khánh Vinh Triệu , Thị Thu Hiền Đào , Thế Đức Tài Lê , Thanh Tòng Trần , Văn Hiếu Phan , Nguyễn Thùy Trang Bùi , Minh Quân Lê , Minh Đương Trần , Đình Thắng Nguyễn , Nhật Tài Nguyễn , Thị Ngọc Lan Vương
Published: January 2022

Mở đầu: COVID-19 đã và đang trở thành gánh nặng y tế toàn cầu. X quang ngực là công cụ hình ảnh học đơn giản giúp chẩn đoán độ nặng và tiên lượng phù hợp trong quản lý bệnh COVID-19. Dữ liệu về đánh giá độ nặng tổn thương phổi trên X quang ở bệnh nhân COVID-19 tại Việt Nam còn hạn chế. Mục tiêu: Nghiên cứu này được tiến hành để mô tả đặc điểm  lâm sàng, mức độ nặng tổn thương phổi trên X quang ngực ở bệnh nhân COVID-19 và đánh giá mối liên quan giữa những yếu tố lâm sàng với độ nặng của tổn thương phổi trên X quang ngực. Đối tượng và phương pháp nghiên cứu: Nghiên cứu hồi cứu trên bệnh nhân nhiễm COVID-19 nhập viện trong khoảng thời gian từ ngày 30/08/2021 đến ngày 30/09/2021. Đánh giá mức độ nặng của tổn thương phổi trên X quang ngực trong 24 giờ đầu nhập viện bằng thang điểm Brixia. Kết quả: Nghiên cứu có 279 bệnh nhân với 57,7% giới nữ, tuổi trung bình 59,6 ± 13,9 và 72,4% bệnh nhân COVID-19 nhập viện có bệnh nền. Điểm Brixia có giá trị trung vị là 13 (9 – 16) điểm. Phổi phải và phổi trái có điểm Brixia lần lượt 7 (5 – 9) và 6 (4 – 8). Vùng thấp của phổi có điểm tổn thương cao hơn so với vùng giữa và trên của phổi. Bệnh nhân thuộc nhóm có điểm Brixia cao có nhịp tim nhanh hơn, BMI cao, điểm NEW2 cao hơn so với nhóm có điểm Brixia thấp (p < 0,05). Tỷ lệ cao thở oxy mask ở nhóm có điểm Brixia thấp là 39,6%, trong khi đó tỷ lệ này là 62,4% ở nhóm có điểm số Brixia cao. Kết luận: Nghiên cứu cho thấy bệnh nhân COVID-19 nhập viện có độ tuổi cao tuổi, với giới nữ chiếm ưu thế và phần lớn bệnh nhân có bệnh nền. Điểm Brixia trong nghiên cứu là cao. Bệnh nhân có điểm Brixia càng cao, tỷ lệ cần hỗ trợ bằng các dụng cụ cung cấp oxy càng cao.
XÁC ĐỊNH TRUNG VỊ CỦA CÁC BIOMARKER TRONG TẦM SOÁT LỆCH BỘI QUÝ 1 THAI KÌ TẠI BỆNH VIỆN ĐẠI HỌC Y DƯỢC TP. HỒ CHÍ MINH
Authors: Thị Hương Xuân Nguyễn , Nhật Thăng Trần
Published: January 2022

Đặt vấn đề:  Thay đổi nồng độ PAPP-A và free beta-hCG (fβ-hCG) trong máu mẹ được chứng minh là có liên quan đến nguy cơ mắc hội chứng Down ở thai nhi. Một số nghiên cứu cho thấy trung vị hai chất này thay đổi theo chủng tộc và không thể giải thích được bằng hiệu chỉnh cân nặng mẹ. Mỗi dân tộc nên có giá trị tham chiếu riêng cho dân số mình. Mục tiêu: Xác định giá trị trung vị của PAPP-A và fβ-hCG của dân số đại học Y Dược Tp. Hồ Chí Minh (ĐHYD). Phương pháp: Nghiên cứu báo cáo loạt ca hồi và tiến cứu 2873 thai phụ đến khám tại đơn vị chẩn đoán trước sanh bệnh viện ĐHYD TP. Hồ Chí Minh được sàng lọc quí 1 thai kì bằng combined test. Kết quả: Trung vị dự đoán: PAPP-A=214,3 – 5,384 x (ngày tuổi thai) + 0,03415 x (ngày tuổi thai)2 r=0,9677; fβ-hCG = 10^ (-0,06799 x (ngày tuổi thai) + 7,581) r= 0,991; Mô hình điều MoM theo cân nặng mẹ: PAPP-A MoM hiệu chỉnh = 0,3628*EXP(0,01705*cân nặng Kg); fβ-hCG MoM hiệu chỉnh = 1,665*EXP(-0,005857*cân nặng Kg); Trung vị MoM PAPP-A khi sử dụng mô hình đặc trưng cho dân số ĐHYD là 0,896 khác biệt với trung vị MoM PAPP-A khi sử dụng mô hình của FMF là 1,064 (95% CI, p< 0.05). Trung vị MoM fβ-hCG khi sử dụng mô hình đặc trưng cho dân số ĐHYD là 1,221 khác biệt với trung vị MoM fβ-hCG khi sử dụng mô hình của FMF là 1,433 (95% CI, p< 0.05). So sánh hai mô hình: Tỉ lệ dương tính của test sàng lọc khi áp dụng MoM- FMF là 7,62%.Tỉ lệ dương tính của test sàng lọc khi áp dụng MoM-ĐHYD là 8,8%. Khi áp dụng MoM-ĐHYD:  Tỉ lệ phát hiện là 100%. Tỉ lệ tiên đoán dương: 7,11%; Tỉ lệ dương giả: 8,18%. Kết luận: Mỗi chủng tộc nên áp dụng giá trị trung vị PAPP-A và fβ-hCG riêng của dân số mình cho sàng lọc lệch bội ba tháng đầu thai kì bằng combined test.
In silico molecular docking of quercetin as anti-colorectal cancer agents by inhibiting LT4AH
Authors: Saputra Made Agus Widiana , Mahaswari Anak Agung Istri Rani , Anggreni Ni Ketut Sri , Putri Wahyu Nadi Eka , Laksmiani Ni Putu Linda
Published: January 2022

Colorectal cancer is a malignant neoplasm originating from the colon or rectum. Overexpression of leukotriene A4 hydrolase (LTA4H) increases the growth of HCT116 colon cancer cells, therefore, this enzyme becomes an attractive target for commercial drug bestatin. Meanwhile, quercetin is a member of flavonoids possessing a wide variety of anticancer. This study aimed to determine the potential of quercetin as anti-colorectal cancer by inhibiting LTA4H through in silico molecular docking. The docking process involved optimizing quercetin structure, preparing LTA4H protein (PDB ID: 3U9W), validating the molecular docking method, and docking quercetin and bestatin on LTA4H. The binding energy of quercetin to LTA4H was -9.57 kcal/mol, while 28P native ligand and bestatin yielded -10.22 kcal/mol and -9.10 kcal/mol, respectively. Based on the binding energy value, quercetin has a potential inhibitory against the LTA4H.
Biomass burning aerosol heating rates from the ORACLES (ObseRvations of Aerosols above CLouds and their intEractionS) 2016 and 2017 experiments
Authors: Cochrane Sabrina P. , Schmidt K. Sebastian , Chen Hong , Pilewskie Peter , Kittelman Scott , Redemann Jens , LeBlanc Samuel , Pistone Kristina , Segal Rozenhaimer Michal , Kacenelenbogen Meloë , Shinozuka Yohei , Flynn Connor , Ferrare Rich , Burton Sharon , Hostetler Chris , Mallet Marc , Zuidema Paquita
Published: January 2022

Abstract. Aerosol heating due to shortwave absorption has
implications for local atmospheric stability and regional dynamics. The
derivation of heating rate profiles from space-based observations is
challenging because it requires the vertical profile of relevant properties
such as the aerosol extinction coefficient and single-scattering albedo
(SSA). In the southeastern Atlantic, this challenge is amplified by the
presence of stratocumulus clouds below the biomass burning plume advected
from Africa, since the cloud properties affect the magnitude of the aerosol
heating aloft, which may in turn lead to changes in the cloud properties and
life cycle. The combination of spaceborne lidar data with passive imagers
shows promise for future derivations of heating rate profiles and curtains,
but new algorithms require careful testing with data from aircraft
experiments where measurements of radiation, aerosol, and cloud parameters
are better colocated and readily available. In this study, we derive heating rate profiles and vertical
cross sections (curtains) from aircraft measurements during the NASA
ObseRvations of Aerosols above CLouds and their intEractionS (ORACLES)
project in the southeastern Atlantic. Spectrally resolved irradiance
measurements and the derived column absorption allow for the separation of
total heating rates into aerosol and gas (primarily water vapor) absorption.
The nine cases we analyzed capture some of the co-variability of heating
rate profiles and their primary drivers, leading to the development of a new
concept: the heating rate efficiency (HRE; the heating rate per unit aerosol
extinction). HRE, which accounts for the overall aerosol loading as well
as vertical distribution of the aerosol layer, varies little with altitude
as opposed to the standard heating rate. The large case-to-case variability
for ORACLES is significantly reduced after converting from heating rate to
HRE, allowing us to quantify its dependence on SSA, cloud albedo, and solar
zenith angle.
A Comparative Evaluation of Snowflake Particle Size and Shape Estimation Techniques used by the Precipitation Imaging Package (PIP), Multi-Angle Snowflake Camera (MASC), and Two-Dimensional Video Disdrometer (2DVD)
Authors: Helms Charles Nelson , Munchak Stephen Joseph , Tokay Ali , Pettersen Claire
Published: January 2022

Abstract. Measurements of snowflake particle size and shape are important for studying the snow microphysics. While a number of instruments exist that are designed to measure these important parameters, this study focuses on the measurement techniques of three digital video disdrometers: the Precipitation Imaging Package (PIP), the Multi-Angle Snowflake Camera (MASC) and the Two-Dimensional Video Disdrometer (2DVD). To gain a better understanding of the relative strengths and weaknesses of these instruments and to provide a foundation upon which comparisons can be made between studies using data from different instruments, we perform a comparative analysis of the measurement algorithms employed by each of the three instruments by applying the algorithms to snowflake images captured by PIP during the ICEP-POP 2018 field campaign. Our analysis primarily focuses on the measurements of area, equivalent diameter, and aspect ratio. Our findings indicate that area and equi-area diameter measurements using the 2DVD camera setup should be the most accurate, followed by MASC, which is slightly more accurate than PIP. In terms of the precision of the area and equi-area diameter measurements, however, MASC is considerably more precise than PIP or 2DVD, which provide similar precision once the effects of the PIP image compression algorithm are taken into account. Both PIP and MASC use shape-fitting algorithms to measure aspect ratio. While our analysis of the MASC aspect ratio suggests the measurements are reliable, our findings indicate that both the ellipse and rectangle aspect ratios produced by PIP under-performed considerably due to the shortcomings of the PIP shape-fitting techniques. That said, we also demonstrate that reliable measurements of aspect ratio can be retrieved from PIP by reprocessing the PIP images using either the MASC shape-fitting technique or a tensor-based ellipse-fitting technique. Because of differences in instrument design, 2DVD produces measurements of particle horizontal and vertical extent rather than length and width. Furthermore, the 2DVD measurements of particle horizontal extent can be contaminated by horizontal particle motion. Our findings indicate that, although the correction technique used to remove the horizontal motion contamination performs remarkably well with snowflakes despite being designed for use with rain drops, the 2DVD measurements of particle horizontal extent are potentially unreliable.
Dissolved organic matter signatures in urban surface waters: spatio-temporal patterns and drivers
Authors: Romero González-Quijano Clara , Herrero Ortega Sonia , Casper Peter , Gessner Mark , Singer Gabriel
Published: January 2022

Abstract. Advances in analytical chemistry have facilitated the characterization of dissolved organic matter (DOM), which has improved understanding of DOM sources and transformations in surface waters. For urban waters, however, where DOM diversity is likely high, the interpretation of DOM signatures is hampered by a lack of basic information. Here we explored the spatiotemporal variation of DOM composition in contrasting urban water bodies, based on spectrophometry and fluorometry, size-exclusion chromatography and ultrahigh-resolution mass spectrometry, to identify linkages between DOM signatures and potential drivers. The highly diverse DOM we observed distinguished lakes and ponds characterized by a high proportion of autochthonous DOM from rivers and streams with more allochthonous DOM. Seasonal variation was apparent in all types of water bodies, driven by the interaction between phenology and urban influences. Specifically, nutrient supply, the percentage of green space adjacent to the water bodies and point source pollution emerged as major urban drivers of DOM composition. Optical DOM properties also revealed the influence of effluents from waste water treatment plants, suggesting their use in water-quality assessment and monitoring. Furthermore, optical measurements inform about processes both within water bodies and in their surroundings, which could improve the assessment of ecosystem functioning and integrity.
Evaluation of Mei-yu heavy-rainfall quantitative precipitation forecasts in Taiwan by a cloud-resolving model for three seasons of 2012–2014
Authors: Wang Chung-Chieh , Chuang Pi-Yu , Chang Chih-Sheng , Tsuboki Kazuhisa , Huang Shin-Yi , Leu Guo-Chen
Published: January 2022

Abstract. In this study, the performance of quantitative precipitation forecasts (QPFs) by the Cloud-Resolving Storm Simulator (CReSS) in Taiwan, at a horizontal grid spacing of 2.5 km and a domain size of 1500×1200 km2, in the range of 1–3 d during three Mei-yu seasons (May–June) of 2012–2014 is evaluated using categorical statistics, with an emphasis on heavy-rainfall events (≥100 mm per 24 h). The categorical statistics are chosen because the main hazards are landslides and floods in Taiwan, so predicting heavy rainfall at the correct location is important. The overall threat scores (TSs) of QPFs for all events on day 1 (0–24 h) are 0.18, 0.15, and 0.09 at thresholds of 100, 250, and 500 mm, respectively, and indicate considerable improvements at increased resolution compared to past results and 5 km models (TS < 0.1 at 100 mm and TS ≤ 0.02 at 250 mm). Moreover, the TSs are shown to be higher and the model more skillful in
predicting larger events, in agreement with earlier findings for typhoons.
After classification based on observed rainfall, the TSs of day − 1 QPFs for the largest 4 % of events by CReSS at 100, 250, and 500 mm (per 24 h) are 0.34, 0.24, and 0.16, respectively, and can reach 0.15 at 250 mm on day 2 (24–48 h) and 130 mm on day 3 (48–72 h). The larger events also exhibit higher probability of detection and lower false alarm ratio than smaller ones almost without exception across all thresholds. With the convection and terrain better resolved, the strength of the model is found to lie mainly in the topographic rainfall in Taiwan rather than migratory events that are more difficult to predict. Our results highlight the crucial importance of cloud-resolving capability and the size of fine mesh for heavy-rainfall QPFs in Taiwan.