bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction: Han et al. MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells. Int. J. Mol. Sci. 2023, 24, 7433
Authors: Han Peifeng , Sunada-Nara Keisuke , Kawashima Nobuyuki , Fujii Mayuko , Wang Shihan , Kieu Thoai Quoc , Yu Ziniu , Okiji Takashi
Published: February 2024

In the original publication, there was a mistake in Figure 4J,K as published [...]
Hybrid 2D Supramolecular Organic Frameworks (SOFs) Assembled by the Cooperative Action of Hydrogen and Halogen Bonding and π⋯π Stacking Interactions
Authors: Baykov Sergey V. , Semenov Artem V. , Presnukhina Sofia I. , Tarasenko Marina V. , Shetnev Anton A. , Frontera Antonio , Boyarskiy Vadim P. , Kukushkin Vadim Yu.
Published: February 2024

The cis- and trans-isomers of 6-(3-(3,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)cyclohex-3-ene-1-carboxylic acid (cis-A and trans-A) were obtained by the reaction of 3,4-dichloro-N′-hydroxybenzimidamide and cis-1,2,3,6-tetrahydrophthalic anhydride. Cocrystals of cis-A with appropriate solvents (cis-A‧½(1,2-DCE), cis-A‧½(1,2-DBE), and cis-A‧½C6H14) were grown from 1,2-dichloroethane (1,2-DCE), 1,2-dibromoethane (1,2-DBE), and a n-hexane/CHCl3 mixture and then characterized by X-ray crystallography. In their structures, cis-A is self-assembled to give a hybrid 2D supramolecular organic framework (SOF) formed by the cooperative action of O–H⋯O hydrogen bonding, Cl⋯O halogen bonding, and π⋯π stacking. The self-assembled cis-A divides the space between the 2D SOF layers into infinite hollow tunnels incorporating solvent molecules. The energy contribution of each noncovalent interaction to the occurrence of the 2D SOF was verified by several theoretical approaches, including MEP and combined QTAIM and NCIplot analyses. The consideration of the theoretical data proved that hydrogen bonding (approx. −15.2 kcal/mol) is the most important interaction, followed by π⋯π stacking (approx. −11.1 kcal/mol); meanwhile, the contribution of halogen bonding (approx. −3.6 kcal/mol) is the smallest among these interactions. The structure of the isomeric compound trans-A does not exhibit a 2D SOF architecture. It is assembled by the combined action of hydrogen bonding and π⋯π stacking, without the involvement of halogen bonds. A comparison of the cis-A structures with that of trans-A indicated that halogen bonding, although it has the lowest energy in cis-A-based cocrystals, plays a significant role in the crystal design of the hybrid 2D SOF. The majority of the reported porous halogen-bonded organic frameworks were assembled via iodine and bromine-based contacts, while chlorine-based systems—which, in our case, are structure-directing—were unknown before this study.
The Potential Role of Genic-SSRs in Driving Ecological Adaptation Diversity in Caragana Plants
Authors: Wang Qinglang , Chen Xing’er , Meng Yue , Niu Miaomiao , Jia Yuanyuan , Huang Lei , Ma Wenhong , Liang Cunzhu , Li Zhiyong , Zhao Liqing , Dang Zhenhua
Published: February 2024

Caragana, a xerophytic shrub genus widely distributed in northern China, exhibits distinctive geographical substitution patterns and ecological adaptation diversity. This study employed transcriptome sequencing technology to investigate 12 Caragana species, aiming to explore genic-SSR variations in the Caragana transcriptome and identify their role as a driving force for environmental adaptation within the genus. A total of 3666 polymorphic genic-SSRs were identified across different species. The impact of these variations on the expression of related genes was analyzed, revealing a significant linear correlation (p < 0.05) between the length variation of 264 polymorphic genic-SSRs and the expression of associated genes. Additionally, 2424 polymorphic genic-SSRs were located in differentially expressed genes among Caragana species. Through weighted gene co-expression network analysis, the expressions of these genes were correlated with 19 climatic factors and 16 plant functional traits in various habitats. This approach facilitated the identification of biological processes associated with habitat adaptations in the studied Caragana species. Fifty-five core genes related to functional traits and climatic factors were identified, including various transcription factors such as MYB, TCP, ARF, and structural proteins like HSP90, elongation factor TS, and HECT. The roles of these genes in the ecological adaptation diversity of Caragana were discussed. Our study identified specific genomic components and genes in Caragana plants responsive to heterogeneous habitats. The results contribute to advancements in the molecular understanding of their ecological adaptation, lay a foundation for the conservation and development of Caragana germplasm resources, and provide a scientific basis for plant adaptation to global climate change.
Modeling the Thermoforming Process of a Complex Geometry Based on a Thermo-Visco-Hyperelastic Model
Authors: Ragoubi Ameni , Ducloud Guillaume , Agazzi Alban , Dewailly Patrick , Le Goff Ronan
Published: February 2024

The thermoforming process is commonly used in industry for the manufacturing of lightweight, thin-walled products from a pre-extruded polymer sheet. Many simulations have been developed to simulate the process and optimize it with computer tools. The development of testing machines has simplified the simulation of this type of process, allowing researchers to characterize the behavior of the material at different temperatures and for large deformation to be closer to the real conditions of the process. This paper presents the results of a study on the modeling of the thermoforming process for an industrial demonstrator made from a high-impact polystyrene (HIPS) polymer. The HIPS shows a mechanical behavior that depends on the temperature and strain rate. In such conditions, a thermo-hyper-viscoelastic constitutive model is used to replicate the thermoforming process of the industrial demonstrator using ABAQUS/Explicit. Its behavior is determined via various experimental tests: uniaxial tensile tests at different temperatures and strain rates and Dynamic Mechanical Analysis (DMA). A comparison between the numerical and experimental results is carried out for the evolution of film thickness. The paper concludes with a discussion of possible improvements to be considered for future simulations of the thermoforming process using Abaqus, which presents complex challenges in terms of contact and material modeling.
Infusion Simulation of Graphene-Enhanced Resin in LCM for Thermal and Chemo-Rheological Analysis
Authors: Alotaibi Hatim , Abeykoon Chamil , Soutis Constantinos , Jabbari Masoud
Published: February 2024

The present numerical study proposes a framework to determine the heat flow parameters—specific heat and thermal conductivity—of resin–graphene nanoplatelets (GNPs) (modified) as well as non-modified resin (with no GNPs). This is performed by evaluating the exothermic reaction which occurs during both the filling and post-filling stages of Liquid Composite Moulding (LCM). The proposed model uses ANSYS Fluent to solve the Stokes–Brinkman (momentum and mass), energy, and chemical species conservation equations to a describe nano-filled resin infusion, chemo-rheological changes, and heat release/transfer simultaneously on a Representative Volume Element (RVE). The transient Volume-of-Fluid (VOF) method is employed to track free-surface propagation (resin–air interface) throughout the computational domain. A User-Defined Function (UDF) is developed together with a User-Defined Scaler (UDS) to incorporate the heat generation (polymerisation), which is added as an extra source term into the energy equation. A separate UDF is used to capture intra-tow (microscopic) flow by adding a source term into the momentum equation. The numerical findings indicate that the incorporation of GNPs can accelerate the curing of the resin system due to the high thermal conductivity of the nanofiller. Furthermore, the model proves its capability in predicting the specific heat and thermal conductivity of the modified and non-modified resin systems utilising the computed heat of reaction data. The analysis shows an increase of ∼15% in the specific heat and thermal conductivity due to different mould temperatures applied (110–170 °C). This, furthermore, stresses the fact that the addition of GNPs (0.2 wt.%) improves the resin-specific heat by 3.68% and thermal conductivity by 58% in comparison to the non-modified thermoset resin. The numerical findings show a satisfactory agreement with and in the range of experimental data available in the literature.
Convergence and Performance Analysis of a Particle Swarm Optimization Algorithm for Optical Tuning of Gold Nanohole Arrays
Authors: Angelini Margherita , Zagaglia Luca , Marabelli Franco , Floris Francesco
Published: February 2024

Gold nanohole arrays, hybrid metal/dielectric metasurfaces composed of periodically arranged air holes in a thick gold film, exhibit versatile support for both localized and propagating surface plasmons. Leveraging their capabilities, particularly in surface plasmon resonance-oriented applications, demands precise optical tuning. In this study, a customized particle swarm optimization algorithm, implemented in Ansys Lumerical FDTD, was employed to optically tune gold nanohole arrays treated as bidimensional gratings following the Bragg condition. Both square and triangular array dispositions were considered. Convergence and evolution of the particle swarm optimization algorithm were studied, and a mathematical model was developed to interpret its outcomes.
Towards Production of Cost-Effective Modification of SmCo5-Type Alloys Suitable for Permanent Magnets
Authors: Gjoka Margarit , Sarafidis Charalampos , Giaremis Stefanos
Published: February 2024

SmCo5 constitutes one of the strongest classes of permanent magnets, which exhibit magnetocrystalline anisotropy with uniaxial character and enormous energy and possess high Curie temperature. However, the performance of SmCo5 permanent magnets is hindered by a limited energy product and relatively high supply risk. Sm is a moderately expensive element within the lanthanide group, while Co is a more expensive material than Fe, making SmCo5-based permanent magnets among the most expensive materials in the group. Subsequently, the need for new materials with less content in critical and thus expensive resources is obvious. A promising path of producing new compounds that meet these requirements is the chemical modification of established materials used in PM towards the reduction of expensive resources, for example, reducing Co content with transition metals (like Fe, Ni) or using as substitutes raw rare earth materials with greater abundance than global demand, like Ce and La. Important instruments to achieve these goals are theoretical calculations, such as ab initio methods and especially DFT-based calculations, in predicting possible stable RE-TM intermetallic compounds and their magnetic properties. This review aims to present the progress of recent years in the production of improved SmCo5-type magnets.
3D Size-Dependent Dynamic Instability Analysis of FG Cylindrical Microshells Subjected to Combinations of Periodic Axial Compression and External Pressure Using a Hermitian C2 Finite Layer Method Based on the Consistent Couple Stress Theory
Authors: Wu Chih-Ping , Wu Meng-Luen , Hsu Hao-Ting
Published: February 2024

This work develops a three-dimensional (3D) weak formulation, based on the consistent couple stress theory (CCST), for analyzing the size-dependent dynamic instability behavior of simply-supported, functionally graded (FG) cylindrical microshells that are subjected to combinations of periodic axial compression and external pressure. In our formulation, the microshells are artificially divided into nl layers. The displacement components of each individual layer are selected as the primary variables, which are expanded as a double Fourier series in the in-plane domain and are interpolated with Hermitian C2 polynomials in the thickness direction. Incorporating the layer-wise displacement models into our weak formulation, we develop a Hermitian C2 finite layer method (FLM) for addressing the current issue. The accuracy and the convergence rate of our Hermitian C2 FLM are validated by comparing the solutions it produces with the accurate two-dimensional solutions of critical loads and critical pressures of FG cylindrical macroshells and single-walled carbon nanotubes, which were reported in the literature. The numerical results show the effects of the material length-scale parameter, the inhomogeneity index, the radius-to-thickness and length-to-radius ratios, the load magnitude ratio, and the static and dynamic load factors on the first principal and first secondary instability regions of parametric resonance of simply-supported FG cylindrical microshells are significant.
Interactions of Galloylated Polyphenols with a Simple Gram-Negative Bacterial Membrane Lipid Model
Authors: Coones Ryan T. , Karonen Maarit , Green Rebecca J. , Frazier Richard
Published: February 2024

Differential scanning calorimetry (DSC) was used to explore the interactions of isolated polyphenolic compounds, including (-)-epigallocatechin gallate ((-)-EGCg), tellimagrandins I and II (Tel-I and Tel-II), and 1,2,3,4,6-penta-O-galloyl-d-glucose (PGG), with a model Gram-negative bacterial membrane with a view to investigating their antimicrobial properties. The model membranes comprised 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) and 1,2-dipalmitoyl-sn-glycero-3-phospho-(1’-rac-glycerol) (DPPG), fabricated to mimic the domain formation observed in natural membranes, as well as ideally mixed lipid vesicles for the interaction with (-)-EGCg. Polyphenols induced changes in lipid mixing/de-mixing depending on the method of vesicle preparation, as was clearly evidenced by alterations in the lipid transition temperatures. There was a distinct affinity of the polyphenols for the DPPG lipid component, which was attributed to the electrostatic interactions between the polyphenolic galloyl moieties and the lipid headgroups. These interactions were found to operate through either the stabilization of the lipid headgroups by the polyphenols or the insertion of the polyphenols into the membrane itself. Structural attributes of the polyphenols, including the number of galloyl groups, the hydrophobicity quantified by partition coefficients (logP), and structural flexibility, exhibited a correlation with the temperature transitions observed in the DSC measurements. This study furthers our understanding of the intricate interplay between the structural features of polyphenolic compounds and their interactions with model bacterial membrane vesicles towards the exploitation of polyphenols as antimicrobials.
Evaluation of a Novel High-Efficiency SHS-EAH Multi-Stage DG-ADP Process for Cleaner Production of High-Quality Ferrovanadium Alloy
Authors: Yu Bin , Yuan Tiechui , Shi Junjie , Li Ruidi , Jiang Chenglong , Ye Mingfeng , Xiao Daihong , Chen Haijun , Zhang Lin , Wang Ning , Gao Leizhang , Yin Danfeng , Zhang Lei , Yang Xiong
Published: February 2024

A novel high-efficiency industrialized clean production technology based on multi-stage gradient batching and smelting was proposed for the production of high-quality ferrovanadium. The thermodynamic mechanism of aluminothermic reduction equilibrium, alloy settlement and raw material impurity distribution were confirmed, and a multi-stage double-gradient aluminum addition pattern (DG-ADP), the highly efficient separation of molten slag and alloy, and typical impurity control standards of raw materials were achieved on the basis of a self-propagating high-temperature synthesis with an electric auxiliary heating (SHS-EAH) process. The reduction efficiency, separation efficiency and the comprehensive utilization rate of the secondary resources were significantly improved, as the whole total vanadium (T.V) content in the industrially produced residue slag reduced from 2.34 wt.% to 0.60 wt.%, while the corresponding smelting yield increased from 93.7 wt.% to 98.7 wt.% and the aluminum consumption decreased from 510 kg·t−1 to 400 kg·t−1. The multi-stage DG-ADP process enabled the internal circulation of vanadium-bearing materials in the ferrovanadium smelting system, as well as the external circulation of iron and residue slag in the same system, and finally achieved the zero discharge of solid and liquid waste from the ferrovanadium production line, which provides a brand-new perspective for the cleaner production of ferrovanadium alloy.
Investigations on the Degradation Behavior of Processed FeMnSi-xCu Shape Memory Alloys
Authors: Roman Ana-Maria , Cimpoeșu Ramona , Pricop Bogdan , Cazacu Marius Mihai , Zegan Georgeta , Istrate Bogdan , Cocean Alexandru , Chelariu Romeu , Moscu Mihaela , Bădărău Gheorghe , Cimpoeșu Nicanor , Ivănescu Mircea Cătălin
Published: February 2024

A new functional Fe-30Mn-5Si-xCu (x = 1.5 and 2 wt%) biomaterial was obtained from the levitation induction melting process and evaluated as a biodegradable material. The degradation characteristics were assessed in vitro using immersion tests in simulated body fluid (SBF) at 37 ± 1 °C, evaluating mass loss, pH variation that occurred in the solution, open circuit potential (OCP), linear and cyclic potentiometry (LP and CP), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and nano-FTIR. To obtain plates as samples, the cast materials were thermo-mechanically processed by hot rolling. Dynamic mechanical analysis (DMA) was employed to evaluate the thermal properties of the smart material. Atomic force microscopy (AFM) was used to show the nanometric and microstructural changes during the hot rolling process and DMA solicitations. The type of corrosion identified was generalized corrosion, and over the first 3–5 days, an increase in mass was observed, caused by the compounds formed at the metal–solution interface. The formed compounds were identified mainly as oxides that passed into the immersion liquid. The degradation rate (DR) was obtained as a function of mass loss, sample surface area and immersion duration. The dynamic mechanical behavior and dimensions of the sample were evaluated after 14 days of immersion. The nanocompounds found on the surface after atmospheric corrosion and immersion in SBF were investigated with the Neaspec system using the nano-FTIR technique.
A High-Performance Cr2O3/CaCO3 Nanocomposite Catalyst for Rapid Hydrogen Generation from NaBH4
Authors: Alshammari Majed , Alshammari Khulaif , Alhassan Sultan , Alshammari Alhulw H. , Alotaibi Turki , Alotibi Satam , Ismael Ali , Taha Taha Abdel Mohaymen
Published: February 2024

This study aims to prepare new nanocomposites consisting of Cr2O3/CaCO3 as a catalyst for improved hydrogen production from NaBH4 methanolysis. The new nanocomposite possesses nanoparticles with the compositional formula Cr2−xCaxO3 (x = 0, 0.3, and 0.6). These samples were prepared using the sol-gel method, which comprises gelatin fuel. The structure of the new composites was studied using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, environmental scanning electron microscopy (ESEM), and X-ray spectroscopy (XPS). The XRD data showed the rhombohedral crystallinity of the studied samples, and the average crystal size was 25 nm. The FTIR measurements represented the absorption bands of Cr2O3 and CaO. The ESEM micrographs of the Cr2O3 showed the spherical shape of the Cr2O3 nanoparticles. The XPS measurements proved the desired oxidation states of the Cr2−xCaxO3 nanoparticles. The optical band gap of Cr2O3 is 3.0 eV, and calcium doping causes a reduction to 2.5 and 1.3 eV at 15.0 and 30.0% doping ratios. The methanolysis of NaBH4 involved accelerated H2 production when using Cr2−xCaxO3 as a catalyst. Furthermore, the Cr1.7Ca0.3O3 catalyst had the highest hydrogen generation rate, with a value of 12,750 mL/g/min.
Strong Room-Temperature Ferromagnetism of MoS2 Compound Produced by Defect Generation
Authors: Park Chang-Soo , Kwon Younghae , Kim Youjoong , Cho Hak Dong , Kim Heetae , Yang Woochul , Kim Deuk Young
Published: February 2024

Ferromagnetic materials have been attracting great interest in the last two decades due to their application in spintronics devices. One of the hot research areas in magnetism is currently the two-dimensional materials, transition metal dichalcogenides (TMDCs), which have unique physical properties. The origins and mechanisms of transition metal dichalcogenides (TMDCs), especially the correlation between magnetism and defects, have been studied recently. We investigate the changes in magnetic properties with a variation in annealing temperature for the nanoscale compound MoS2. The pristine MoS2 exhibits diamagnetic properties from low-to-room temperature. However, MoS2 compounds annealed at different temperatures showed that the controllable magnetism and the strongest ferromagnetic results were obtained for the 700 °C-annealed sample. These magnetizations are attributed to the unpaired electrons of vacancy defects that are induced by annealing, which are confirmed using Raman spectroscopy and electron paramagnetic resonance spectroscopy (EPR).
The Role of NAD+ and NAD+-Boosting Therapies in Inflammatory Response by IL-13
Authors: Pugel Anton D. , Schoenfeld Alyssa M. , Alsaifi Sara Z. , Holmes Jocelyn R. , Morrison Brad E.
Published: February 2024

The essential role of nicotinamide adenine dinucleotide+ (NAD+) in redox reactions during oxidative respiration is well known, yet the coenzyme and regulator functions of NAD+ in diverse and important processes are still being discovered. Maintaining NAD+ levels through diet is essential for health. In fact, the United States requires supplementation of the NAD+ precursor niacin into the food chain for these reasons. A large body of research also indicates that elevating NAD+ levels is beneficial for numerous conditions, including cancer, cardiovascular health, inflammatory response, and longevity. Consequently, strategies have been created to elevate NAD+ levels through dietary supplementation with NAD+ precursor compounds. This paper explores current research regarding these therapeutic compounds. It then focuses on the NAD+ regulation of IL-13 signaling, which is a research area garnering little attention. IL-13 is a critical regulator of allergic response and is associated with Parkinson’s disease and cancer. Evidence supporting the notion that increasing NAD+ levels might reduce IL-13 signal-induced inflammatory response is presented. The assessment is concluded with an examination of reports involving popular precursor compounds that boost NAD+ and their associations with IL-13 signaling in the context of offering a means for safely and effectively reducing inflammatory response by IL-13.
An Esterase-Responsive SLC7A11 shRNA Delivery System Induced Ferroptosis and Suppressed Hepatocellular Carcinoma Progression
Authors: Zhang Hui , Wang Jianguo , Xiang Xiaonan , Xie Chang , Lu Xinfeng , Guo Haijun , Sun Yiyang , Shi Zhixiong , Song Hongliang , Qiu Nasha , Xu Xiao
Published: February 2024

Ferroptosis has garnered attention as a potential approach to fight against cancer, which is characterized by the iron-driven buildup of lipid peroxidation. However, the robust defense mechanisms against intracellular ferroptosis pose significant challenges to its effective induction. In this paper, an effective gene delivery vehicle was developed to transport solute carrier family 7 member 11 (SLC7A11) shRNA (shSLC7A11), which downregulates the expression of the channel protein SLC7A11 and glutathione peroxidase 4 (GPX4), evoking a surge in reactive oxygen species production, iron accumulation, and lipid peroxidation in hepatocellular carcinoma (HCC) cells, and subsequently leading to ferroptosis. This delivery system is composed of an HCC-targeting lipid layer and esterase-responsive cationic polymer, a poly{N-[2-(acryloyloxy)ethyl]-N-[p-acetyloxyphenyl]-N} (PQDEA) condensed shSLC7A11 core (G−LPQDEA/shSLC7A11). After intravenous (i.v.) injection, G−LPQDEA/shSLC7A11 quickly accumulated in the tumor, retarding its growth by 77% and improving survival by two times. This study is the first to construct a gene delivery system, G−LPQDEA/shSLC7A11, that effectively inhibits HCC progression by downregulating SLC7A11 expression. This underscores its therapeutic potential as a safe and valuable candidate for clinical treatment.
Using Natural Dye Additives to Enhance the Energy Conversion Performance of a Cellulose Paper-Based Triboelectric Nanogenerator
Authors: Piwbang Supisara , Kaeochana Walailak , Luechar Pawonpart , Bunriw Weeraya , Chimsida Praphadsorn , Yamklang Wimonsiri , Sintusiri Jirapan , Harnchana Viyada
Published: February 2024

Green and sustainable power sources for next-generation electronics are being developed. A cellulose paper-based triboelectric nanogenerator (TENG) was fabricated to harness mechanical energy and convert it into electricity. This work proposes a novel approach to modify cellulose paper with natural dyes, including chlorophyll from spinach, anthocyanin from red cabbage, and curcumin from turmeric, to enhance the power output of a TENG. All the natural dyes are found to effectively improve the energy conversion performance of a cellulose paper-based TENG due to their photogenerated charges. The highest power density of 3.3 W/m2 is achieved from the cellulose paper-based TENG modified with chlorophyll, which is higher than those modified with anthocyanin and curcumin, respectively. The superior performance is attributed not only to the photosensitizer properties but also the molecular structure of the dye that promotes the electron-donating properties of cellulose.
Advancing Molecular Weight Determination of Lignin by Multi-Angle Light Scattering
Authors: Clobes Mason L. , Kozliak Evguenii I. , Kubátová Alena
Published: February 2024

Due to the complexity and recalcitrance of lignin, its chemical characterization is a key factor preventing the valorization of this abundant material. Multi-angle light scattering (MALS) is becoming a sought-after technique for absolute molecular weight (MW) determination of polymers and proteins. Lignin is a suitable candidate for MW determination via MALS, yet further investigation is required to confirm its absolute MW values and molecular size. Studies aiming to break down lignin into a variety of renewable products will benefit greatly from a simple and reliable determination method like MALS. Recent pioneering studies, discussed in this review, addressed several key challenges in lignin’s MW characterization. Nevertheless, some lignin-specific issues still need to be considered for in-depth characterization. This study explores how MALS instrumentation manages the complexities of determining lignin’s MW, e.g., with simultaneous fractionation and fluorescence interference mitigation. Additionally, we rationalize the importance of a more detailed light scattering analysis for lignin characterization, including aspects like the second virial coefficient and radius of gyration.
Hydrogel Based on Chitosan/Gelatin/Poly(Vinyl Alcohol) for In Vitro Human Auricular Chondrocyte Culture
Authors: Ortega-Sánchez Carmina , Melgarejo-Ramírez Yaaziel , Rodríguez-Rodríguez Rogelio , Jiménez-Ávalos Jorge Armando , Giraldo-Gomez David M. , Gutiérrez-Gómez Claudia , Rodriguez-Campos Jacobo , Luna-Bárcenas Gabriel , Velasquillo Cristina , Martínez-López Valentín , García-Carvajal Zaira Y.
Published: February 2024

Three-dimensional (3D) hydrogels provide tissue-like complexities and allow for the spatial orientation of cells, leading to more realistic cellular responses in pathophysiological environments. There is a growing interest in developing multifunctional hydrogels using ternary mixtures for biomedical applications. This study examined the biocompatibility and suitability of human auricular chondrocytes from microtia cultured onto steam-sterilized 3D Chitosan/Gelatin/Poly(Vinyl Alcohol) (CS/Gel/PVA) hydrogels as scaffolds for tissue engineering applications. Hydrogels were prepared in a polymer ratio (1:1:1) through freezing/thawing and freeze-drying and were sterilized by autoclaving. The macrostructure of the resulting hydrogels was investigated by scanning electron microscopy (SEM), showing a heterogeneous macroporous structure with a pore size between 50 and 500 μm. Fourier-transform infrared (FTIR) spectra showed that the three polymers interacted through hydrogen bonding between the amino and hydroxyl moieties. The profile of amino acids present in the gelatin and the hydrogel was determined by ultra-performance liquid chromatography (UPLC), suggesting that the majority of amino acids interacted during the formation of the hydrogel. The cytocompatibility, viability, cell growth and formation of extracellular matrix (ECM) proteins were evaluated to demonstrate the suitability and functionality of the 3D hydrogels for the culture of auricular chondrocytes. The cytocompatibility of the 3D hydrogels was confirmed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reaching 100% viability after 72 h. Chondrocyte viability showed a high affinity of chondrocytes for the hydrogel after 14 days, using the Live/Dead assay. The chondrocyte attachment onto the 3D hydrogels and the formation of an ECM were observed using SEM. Immunofluorescence confirmed the expression of elastin, aggrecan and type II collagen, three of the main components found in an elastic cartilage extracellular matrix. These results demonstrate the suitability and functionality of a CS/Gel/PVA hydrogel as a 3D support for the auricular chondrocytes culture, suggesting that these hydrogels are a potential biomaterial for cartilage tissue engineering applications, aimed at the regeneration of elastic cartilage.
Assessing the Mode of Biblical Interpretation in the Light of African Biblical Hermeneutics: The Case of the Mother-Tongue Biblical Interpretation in Ghana
Authors: Antwi Emmanuel Kojo Ennin
Published: February 2024

In establishing the Christian faith on African soil, the first missionaries to Africa came along with the Bible. They were determined to share the word of God with the indigenous Africans. This was undertaken effectively; however, it came at a cost. In an attempt to produce translated versions of the Bible for the natives, they ended up producing translations, some of which did not reflect the thoughts of the indigenous people. This has called for an enterprise whereby these texts need to be retranslated and interpreted to reflect the thoughts of the indigenous people. Mother-tongue biblical hermeneutics in Ghana has been advantageous to this enterprise since it seeks to remedy the situation by examining the mother-tongue translations and making proposals for retranslations and interpretation. This has attracted some scholars to come up with a methodology and approaches that would be appropriate in this direction. This paper seeks to assess and evaluate the use of the mother-tongue interpretation, as well as its methodology and approaches in Ghana in the light of African biblical hermeneutics. Though this enterprise is recommendable to African exegetes, it is a special area of biblical studies in search of a standard methodological approach. The paper calls for much attention to how the mother-tongue interpretation could bring the meaning of the text closer to the culture of the Ghanaian reader—however, not at the expense of neglecting the cultural milieu of the original author in which the text was couched.
“Normalcy” in Behavioral Philosophy and in Spiritual Practice
Authors: Fatic Aleksandar
Published: February 2024

This paper introduces the concept of behavioral philosophy, discusses its relationship to philosophical counseling and psychotherapy, and focuses on the concept of normalcy as the normative foundation for a broader discussion on pathology versus philosophical dysfunctionality in life. Following the starting definitions, the argument proceeds to considering how normalcy as a normative foundation of both behavioral philosophy and philosophical counseling and of psychotherapy (along with pathology and pathologization) plays a role in the perspective of behavioral self-improvement sought by behavioral philosophy and by psychotherapy (for various reasons, depending on the psychotherapeutic school and methodology). The author concludes that normalcy, rather than pathology or mental disorder, is the focal concept to discuss in order to understand the role of spirituality and spiritual conviction and belief within the context of therapeutic change, whether it is interpreted philosophically or strictly psychotherapeutically.
The Paradoxes of Modern Islamic Discourses and Socio-Religious Transformation in the Digital Age
Authors: Khamis Sahar
Published: February 2024

The introduction of the internet brought about many transformations in the political, social, cultural, and educational fields worldwide. This phenomenon of digital transformation introduced a myriad of positive, negative, and paradoxical impacts. This critical essay tackles some of the significant transformations and paradoxes which the introduction of the internet invited in modern Muslim societies, with a special focus on two specific domains. First, the realm of religious authority or obtaining authoritative religious knowledge in the age of the internet. Second, the realm of shifting gendered Islamic identities in the age of cyberspace. In exploring these complex and hybrid phenomena, special attention is paid to the tensions between the opposing forces of tradition and modernity, diversity and cohesion, hegemony and resistance, and globalization and localization in cyberspace, and their numerous and far-reaching effects.
Enhancing Stress Detection: A Comprehensive Approach through rPPG Analysis and Deep Learning Techniques
Authors: Fontes Laura , Machado Pedro , Vinkemeier Doratha , Yahaya Salisu , Bird Jordan J. , Ihianle Isibor Kennedy
Published: February 2024

Stress has emerged as a major concern in modern society, significantly impacting human health and well-being. Statistical evidence underscores the extensive social influence of stress, especially in terms of work-related stress and associated healthcare costs. This paper addresses the critical need for accurate stress detection, emphasising its far-reaching effects on health and social dynamics. Focusing on remote stress monitoring, it proposes an efficient deep learning approach for stress detection from facial videos. In contrast to the research on wearable devices, this paper proposes novel Hybrid Deep Learning (DL) networks for stress detection based on remote photoplethysmography (rPPG), employing (Long Short-Term Memory (LSTM), Gated Recurrent Units (GRU), 1D Convolutional Neural Network (1D-CNN)) models with hyperparameter optimisation and augmentation techniques to enhance performance. The proposed approach yields a substantial improvement in accuracy and efficiency in stress detection, achieving up to 95.83% accuracy with the UBFC-Phys dataset while maintaining excellent computational efficiency. The experimental results demonstrate the effectiveness of the proposed Hybrid DL models for rPPG-based-stress detection.
Projection-Angle-Sensor-Assisted X-ray Computed Tomography for Cylindrical Lithium-Ion Batteries
Authors: Dong Jiawei , Ju Lingling , Jiang Quanyuan , Geng Guangchao
Published: February 2024

X-ray computed tomography (XCT) has become a powerful technique for studying lithium-ion batteries, allowing non-destructive 3D imaging across multiple spatial scales. Image quality is particularly important for observing the internal structure of lithium-ion batteries. During multiple rotations, the existence of cumulative errors and random errors in the rotary table leads to errors in the projection angle, affecting the imaging quality of XCT. The accuracy of the projection angle is an important factor that directly affects imaging. However, the impact of the projection angle on XCT reconstruction imaging is difficult to quantify. Therefore, the required precision of the projection angle sensor cannot be determined explicitly. In this research, we selected a common 18650 cylindrical lithium-ion battery for experiments. By setting up an XCT scanning platform and installing an angle sensor to calibrate the projection angle, we proceeded with image reconstruction after introducing various angle errors. When comparing the results, we found that projection angle errors lead to the appearance of noise and many stripe artifacts in the image. This is particularly noticeable in the form of many irregular artifacts in the image background. The overall variation and residual projection error in detection indicators can effectively reflect the trend in image quality. This research analyzed the impact of projection angle errors on imaging and improved the quality of XCT imaging by installing angle sensors on a rotary table.
Detection of Rehabilitation Training Effect of Upper Limb Movement Disorder Based on MPL-CNN
Authors: Shi Lijuan , Wang Runmin , Zhao Jian , Zhang Jing , Kuang Zhejun
Published: February 2024

Stroke represents a medical emergency and can lead to the development of movement disorders such as abnormal muscle tone, limited range of motion, or abnormalities in coordination and balance. In order to help stroke patients recover as soon as possible, rehabilitation training methods employ various movement modes such as ordinary movements and joint reactions to induce active reactions in the limbs and gradually restore normal functions. Rehabilitation effect evaluation can help physicians understand the rehabilitation needs of different patients, determine effective treatment methods and strategies, and improve treatment efficiency. In order to achieve real-time and accuracy of action detection, this article uses Mediapipe’s action detection algorithm and proposes a model based on MPL-CNN. Mediapipe can be used to identify key point features of the patient’s upper limbs and simultaneously identify key point features of the hand. In order to detect the effect of rehabilitation training for upper limb movement disorders, LSTM and CNN are combined to form a new LSTM-CNN model, which is used to identify the action features of upper limb rehabilitation training extracted by Medipipe. The MPL-CNN model can effectively identify the accuracy of rehabilitation movements during upper limb rehabilitation training for stroke patients. In order to ensure the scientific validity and unified standards of rehabilitation training movements, this article employs the postures in the Fugl-Meyer Upper Limb Rehabilitation Training Functional Assessment Form (FMA) and establishes an FMA upper limb rehabilitation data set for experimental verification. Experimental results show that in each stage of the Fugl-Meyer upper limb rehabilitation training evaluation effect detection, the MPL-CNN-based method’s recognition accuracy of upper limb rehabilitation training actions reached 95%. At the same time, the average accuracy rate of various upper limb rehabilitation training actions reaches 97.54%. This shows that the model is highly robust across different action categories and proves that the MPL-CNN model is an effective and feasible solution. This method based on MPL-CNN can provide a high-precision detection method for the evaluation of rehabilitation effects of upper limb movement disorders after stroke, helping clinicians in evaluating the patient’s rehabilitation progress and adjusting the rehabilitation plan based on the evaluation results. This will help improve the personalization and precision of rehabilitation treatment and promote patient recovery.
Forestry Applications of Space-Borne LiDAR Sensors: A Worldwide Bibliometric Analysis
Authors: Aguilar Fernando J. , Rodríguez Francisco A. , Aguilar Manuel A. , Nemmaoui Abderrahim , Álvarez-Taboada Flor
Published: February 2024

The 21st century has seen the launch of new space-borne sensors based on LiDAR (light detection and ranging) technology developed in the second half of the 20th century. Nowadays, these sensors offer novel opportunities for mapping terrain and canopy heights and estimating aboveground biomass (AGB) across local to regional scales. This study aims to analyze the scientific impact of these sensors on large-scale forest mapping to retrieve 3D canopy information, monitor forest degradation, estimate AGB, and model key ecosystem variables such as primary productivity and biodiversity. A worldwide bibliometric analysis of this topic was carried out based on up to 412 publications indexed in the Scopus database during the period 2004–2022. The results showed that the number of published documents increased exponentially in the last five years, coinciding with the commissioning of two new LiDAR space missions: Ice, Cloud, and Land Elevation Satellite (ICESat-2) and Global Ecosystem Dynamics Investigation (GEDI). These missions have been providing data since 2018 and 2019, respectively. The journal that demonstrated the highest productivity in this field was “Remote Sensing” and among the leading contributors, the top five countries in terms of publications were the USA, China, the UK, France, and Germany. The upward trajectory in the number of publications categorizes this subject as a highly trending research topic, particularly in the context of improving forest resource management and participating in global climate treaty frameworks that require monitoring and reporting on forest carbon stocks. In this context, the integration of space-borne data, including imagery, SAR, and LiDAR, is anticipated to steer the trajectory of this research in the upcoming years.
GNSS Spoofing Detection via the Intersection Angle between Two Directions of Arrival in a Single Rotating Antenna
Authors: Chen Shimiao , Ni Shuyan , Lei Tuofeng , Cheng Lingfeng , Song Xin
Published: February 2024

Spoofing against the Global Navigation Satellite System (GNSS) is an attack with strong concealment, posing a significant threat to the security of the GNSS. Many strategies have been developed to prevent such attacks, but current detection methods based on signal direction for multi-agent spoofing require multiple antennas/receivers, leading to increased cost and complexity in implementation. Additionally, methods utilizing a moving single antenna cannot effectively detect multi-agent spoofing. Therefore, we introduce a novel spoofing-detection technique based on the intersection angle between two directions of arrival (IA-DOA) using a single rotating antenna. The essence of this approach lies in estimating the IA-DOA between a pair of signals by utilizing the carrier-to-noise ratio (CNR) and carrier phase single difference (CPSD) of the received signal. The estimation of IA-DOA should be consistent with the prediction when there is no spoofing. With spoofing, it is difficult to accurately simulate the directionality of navigation signals, which can disrupt the consistency between the estimation and prediction of IA-DOA. Therefore, estimations and predictions of IA-DOA can be used to establish detection variables through generalized likelihood ratio testing (GLRT) to detect multi-agent spoofing. We conducted a simulation to analyze the impact of the antenna’s parameters on the detection performance and evaluated it through on-site experiments. The results indicate that the method proposed in this article can efficiently achieve real-time detection of multi-agent spoofing.
Financial Perspectives on Human Capital: Building Sustainable HR Strategies
Authors: Matei Mirabela-Constanța , Abrudan Leonard-Călin , Abrudan Maria-Madela
Published: February 2024

This paper examines the challenges surrounding sustainable human resources management (HRM), particularly in the context of budget constraints that often lead to the reduction of employee development investments. Our research focuses on developing a comprehensive model that integrates financial management tools into HRM strategies, ensuring the prioritization of sustainable practices. Through a systematic analysis of existing knowledge, we propose a solution-oriented approach that supports the financial substantiation of investments in employee development. This study addresses key research questions, emphasizing the adaptation of corporate finance tools to meet HR’s specific requirements. Our research not only identifies challenges but, more importantly, offers solutions by presenting a model that empowers organizations to align financial goals with HR development objectives. The results of our research aim to formulate a pragmatic and inventive model, offering a systematic framework for assessing the financial feasibility of initiatives in human resources development. Our model offers a practical framework for assessing the financial feasibility of HR development initiatives, facilitating informed decision-making and the promotion of sustainable HRM practices.
EL CUIDADO EN EL CENTRO DE LOS NUEVOS ACUERDOS SOCIALES
Authors: Batthyány Karina
Published: February 2024

La desigualdad social y de género es una característica estructural de América Latina y el Caribe, cuyas diversas dimensiones resultaron seriamente agravadas a raíz de la pandemia de COVID-19. Una de ellas en particular quedó expuesta con mucha claridad: la in-justa organización social del cuidado. La provisión del cuidado en la región es fundamentalmente familiar y femenina debido a que los cuidados han sido el componente del bienestar más difícil de delegar o externalizar fuera de la familia. Puede afirmarse, por tanto, que existe una crisis del cuidado en tanto desajuste entre los potenciales cuidadores y las necesidades de cuidado demandadas por la población. Esta crisis se ha profundizado debido a la reducción de las personas disponibles para brindar cuidados, y al aumento de las personas que requieren cuidados y es un nudo crítico de las desigualdades, por lo que la construcción de nuevos acuerdos sociales debe incorporar centralmente este tema.
En jouant avec les poupées russes : 88 manuscrits grecs de Gabriel Naudé, dont 50 de Guillaume Sirleto, dont certains de Marcel Cervini, dont 2 d’Ange Colocci
Authors: Cardinali Giacomo
Published: February 2024

Following traces of purchases made by Gabriel Naudé in Rome, we discovered that, while searching for volumes for his mentor’s, cardinal Julius Mazerino, personal library, he happened to enrich his own collection too with manuscripts from the Altemps dukes. Among them, we found manuscripts previously owned by the Cardinals Sirleto and Cervini : the vast majority of the Greek volumes owned by Naudé show signs of such origin and represents part of the Greek paper copies from the first half of the 16th century currently part of the Parisini graeci

collection of the National French Library.
Références à l’Antiquité dans les inscriptions médiévales
Authors: Favreau Robert
Published: February 2024

Il n’est pas rare de trouver dans les épitaphes des références à de grands personnages de l’Antiquité auxquels le défunt est comparé, éloquent comme Cicéron, sage comme Caton, etc. Dans bien d’autres types d’inscriptions, coupes, tapisseries, stalles, etc., on a des renvois à ces personnages, à des sentences qui leur sont attribuées. Enfin on cite directement des passages d’auteurs de l’Antiquité ; en outre on a christianisé des oeuvres de basse antiquité, Physiologus, oracles sibyllins, qui ont eu une grande fortune. Pour qui s’intéresse à la connaissance de l’Antiquité au Moyen Âge, les sources épigraphiques ne doivent pas être négligées, d’autant plus qu’elles donnent des repères chronologiques et géographiques utiles.