bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging antimicrobial susceptibility methods in monitoring colistin-resistant Enterobacteriaceae
Authors:   Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Romania, VRANCIANU CORNELIU OVIDIU ,   Earth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, University of  Bucharest, Bucharest, Romania, CRISTIAN ROXANA-ELENA ,   Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Romania,   Earth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, University of  Bucharest, Bucharest, Romania, GHEORGHE-BARBU IRINA ,   Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Romania,   Earth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, University of  Bucharest, Bucharest, Romania, BARBU CZOBOR ILDA ,   Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Romania,   Earth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, University of  Bucharest, Bucharest, Romania, CONSTANTIN MARIAN ,   Microbiology Department, Institute of Biology, Romanian Academy, Bucharest, Romania, CRUNTEANU IOANA ,   Faculty of Medicine, ”Titu Maiorescu” University, Bucharest, Romania, TUDORACHE SORIN IOAN ,   Faculty of Medicine, ”Titu Maiorescu” University, Bucharest, Romania
Published: April 2024

One of the most important essential pillars in the fight against antibiotic resistance is to optimize antibiotic treatment by developing and optimizing appropriate methods to establish the antibiotic susceptibility profiles of a specific microbial strain. Moreover, this will contribute to the suveillance and limitation of antimicrobial resistance transmission and spread. Therefore, it is also imperative to harmonize different approaches and techniques and to perform suitable antimicrobial susceptibility tests in microbiology laboratories to achieve precise, reproducible, and comparable results. However, the conventional methods for antimicrobial susceptibility testing are usually based on bacterial culture methods, which are time-consuming, complicated, and labor-intensive. Therefore, other approaches are needed to address these issues. In this mini-review, we will present the common and future perspectives in antimicrobial susceptibility testing. Microfluidic technology and electrochemical devices have recently gained significant attention in infection management. These advantages include rapid detection, high sensitivity and specificity, highly automated assay, simplicity, low cost, and potential for point-of-care testing in low-resource areas.
Los textos auténticos en la escuela secundaria
Authors: Jiménez Manuel
Published: April 2024

Resumen
EFEKTIVITAS BAHASA VISUAL POSTER UNTUK MENGETAHUI DAMPAK NEGATIF NARKOBA BAGI MAHASISWA PADA KAMPANYE ANTI NARKOBA DI LINGKUNGAN KAMPUS MERCU BUANA DENGAN MODEL EPIC
Authors: Ulita Novena , Fahlan Ahmad Syauqi , Hakam Abdurrahman , Argakusmah Lucky , Islami Intan
Published: April 2024

Posters are one of the media that is close to reaching students to convey information or messages. As an educational institution, Mercubuana University actively provides education for students, one of which is voicing the dangers of drugs for students. The Anti-Drug Campaign carried out by Mercubuana University uses posters posted around the campus. However, as a campaign it is necessary to evaluate the level of effectiveness of the media in conveying information/messages to students so that it achieves the intended goals. To know this, several theories are needed, including visual language theory, color theory, and the EPIC model of communication effectiveness theory. The method used in this research is a quantitative method with a Likert scale using the EPIC model approach. The EPIC variable (empathy, persuasion, impact, communication) is used to measure the effectiveness of posters as part of campaign media. The results of this research show that there is the influence of visual elements, especially illustration elements, which can build persuasion with a value of 4.33, so that visual elements greatly influence the effectiveness of a poster, especially illustration attributes. Thus, in this research, it is proven that posters are an effective medium in conveying messages in the anti-drug campaign carried out by Mercubuana University. In particular, posters are effective because they are influenced by illustration, color and typography attributes that build the visual language of the campaign and this needs to be taken into account by designers.Keywords: effectiveness, social campaign, poster, visual language, visual communication, EPIC Model
Once again about the translation principles of Epiphanius Slavinetsky and Euphemia Chudovsky (based on the material "Epitomy")
Authors: Ivanova Elizaveta Vyacheslavovna
Published: April 2024

The subject of the study is the linguistic features of the Slavic translation of the Epitomies by Konstantin Armenopoul, performed by Epiphanius Slavinetsky. The object of study was the translation itself, presented in several major manuscripts. The work on the Epitomies belongs to one of the early works of Epiphanius in Moscow, since the Kiev scribe began it in 1652-1653. In the course of the analysis, we considered both the earliest discovered lists of "Epitomies" and the latest (up to the end of the XIX – beginning XX centuries), however, the most important textual and linguistic material is presented in the following lists: Usp. 91, GIM – a draft of the hand of Epiphany Slavinetsky; Und. 40, RGB – records of active editorial editing; Sin. 129, GIM – the final version, rewritten by Euphemia Monstrosky. The work uses the linguotextological method, as well as methods of continuous sampling, analytical observation and comparison of the Slavic text with the original in Greek. The novelty of the study consists in the introduction into scientific circulation of lists that have not been studied by researchers in the linguistic aspect before. The analysis of the Epitomium material not only makes it possible to reconstruct the history of the text, but also has fundamental linguistic significance. It makes it possible to summarize the general and highlight the differences in the linguistic features of Epiphanius Slavinetsky and his pupil Euphemia Chudovsky. Thus, the author of the translation, Epiphany Slavinetsky, and the editor, Euphemia Chudovsky, have different linguistic orientations – the first relies more on Slavic grammars, and for the second it is important to convey the Greek original as accurately as possible, which also leads to the elimination of regionalisms characteristic of the Ukrainian-Belarusian translation of Church Slavonic, and the Grecization of the text.
Narrowband Clusteroluminescence with 100% Quantum Yield Enabled by Through-Space Conjugation of Asymmetric Conformation
Authors: Wang Yipu , Zhang Jianyu , Tu Weihao , Wang Lei , Xie Yuan , Sun Jing Zhi , Huang Feihe , Zhang Haoke , Tang Ben Zhong
Published: April 2024

Different from traditional organic luminescent materials based on covalent delocalization, clusteroluminescence (CL) from nonconjugated luminogens relies on noncovalent through-space conjugation (TSC) of electrons. However, such spatial electron delocalization is usually weak, resulting in low luminescent efficiency and board emission peak due to multiple vibrational energy levels. Herein, several nonconjugated luminogens are constructed by employing biphenyl as the building unit to reveal the structure-property relationship and solve current challenges. The intramolecular TSC could be gradually strengthened by introducing building units and stabilized by rigid molecular skeleton and multiple intermolecular interactions. Surprisingly, narrowband CL with full width at half-maximum of 40 nm and 100% efficiency is successfully achieved via an asymmetric conformation, exhibiting comparable performance to the traditional conjugated luminogens. This work realizes highly efficient and narrowband CL from nonconjugated luminogens and highlights the essential role of structural conformation in manipulating the photophysical properties of unconventional luminescent materials.
Extracellular vesicles in the pathogenesis of Campylobacter jejuni
Authors: Malet-Villemagne Jeanne , Vidic Jasmina
Published: April 2024

Bacteria in genus Campylobacter are the leading cause of foodborne infections worldwide. Here we describe the roles of extracellular vesicles in the pathogenesis of these bacteria and current knowledge of vesicle biogenesis. We also discuss the advantages of this alternative secretion pathway for bacterial virulence.
Cycloadditions of 5-Vinyloxazolidine-2,4-diones: A Straightfor-ward Access to the (thio)Hydantoin Scaffold
Authors: Busicchia Marc , Roblin Antoine , Dubois Carla , Mekranter Nagy , Casaretto Nicolas , Archambeau Alexis
Published: April 2024

A palladium-catalyzed (3+2) cycloaddition between 5-vinyloxazolidine-2,4-diones (VOxD) and (thio)isocyanates is described. Under optimized conditions, an array of (thio)hydantoins was readily prepared and an enantioselective version of this transformation was then studied. To illustrate the importance of this method, a concise synthesis of two bioactive compounds, nirvanol and mephenytoin, was carried out. This work emphasizes the synthetic potential of VOxD as useful precursors of zwitterionic aza-π- allylpalladium II intermediates.
MatchMass: A Web-Based Tool for Efficient Mass Spectrometry Data Analysis
Authors: Ustrnul Lukas , Jarg Tatsiana , Jantson Martin , Osadchuk Irina , Anton Lauri , Aav Riina
Published: April 2024

MatchMass is a user-friendly web-based application designed to streamline the analysis of mass spectrometry (MS) data for researchers studying complex mixtures of molecules. Users upload experimental data (m/z and abundance) and a list of theoretical monoisotopic masses. MatchMass then identifies matching molecules within the sample based on user-defined parameters (mass accuracy, abundance threshold, and ions of interest). The tool generates a visual comparison of experimental and theoretical m/z values, facilitates result exploration, and allows download of comprehensive reports. MatchMass eliminates the need for manual data processing, improving efficiency and accuracy in MS data analysis, particularly for researchers working with complicated mixtures.
Dynamic Implications of Non-Covalent Interactions in Amphiphilic Single-Chain Polymer Nanoparticles
Authors: Dykeman-Bermingham Peter , Stingaciu Laura-Roxana , Do Changwoo , Knight Abigail
Published: April 2024

Single-chain polymer nanoparticles (SCNPs) combine the chemical diversity of synthetic polymers with the intricate structure of biopolymers, generating versatile biomimetic materials. The mobility of polymer chain segments at length scales similar to secondary structural elements in proteins are critical to SCNP structure and thus function. However, the influence of non-covalent interactions used to form SCNPs (e.g., hydrogen-bonding and biomimetic secondary-like structure) on these conformational dynamics is challenging to quantitatively assess. To isolate the effects of non-covalent interactions on SCNP structure and conformational dynamics, we synthesized a series of amphiphilic copolymers containing dimethylacrylamide and monomers capable of forming these different interactions: 1) di(phenylalanine) acrylamide that forms intramolecular β-sheet-like crosslinks, 2) phenylalanine acrylamide that forms hydrogen-bonds, but lacks a defined local structure, and 3) benzyl acrylamide that has lowest propensity for hydrogen-bonding. Each SCNP formed folded structures comparable to those of intrinsically disordered proteins, as observed by size exclusion chromatography and Small Angle Neutron Scattering. The dynamics of these polymers, as characterized by a combination of dynamic light scattering and Neutron Spin Echo spectroscopy, was well described using the Zimm with internal friction (ZIF) model, high-lighting the role of each non-covalent interaction to additively restrict the internal relaxations of SCNPs. These results demonstrate the utility of local scale interactions to control SCNP polymer dynamics, guiding the design of functional biomimetic materials with refined binding sites and tunable kinetics.
Emerging conformational-analysis protocols from the RTCONF-16K reaction thermochemistry conformational benchmark set
Authors: Mészáros Bence Balázs , Kubicskó Károly , Németh Dávid Dorián , Daru János
Published: April 2024

Here, we provide a new, realistic reactive conformational analysis benchmark set (RTCONF-16) based on state-of-the-art and cost-efficient methods to assess different protocols. Our comprehensive reference calculations were used to underpin the accuracy of the CENSO (JPCA, 2021, 125, 4039) procedure and to provide alternative recipes with different cost-accuracy compromises. Our general-purpose and economical protocols (CENSO-light and zero, respectively), were found to be 10-30 times faster than the original algorithm while adding only 0.4-0.7 kcal/mol absolute error to the relative free energy estimates.
LC-HRMS analysis of phospholipids bearing oxylipins
Authors: Carpanedo Laura , Rund Katharina M. , Wende Luca M. , Kampschulte Nadja , Schebb Nils Helge
Published: April 2024

Several oxylipins including hydroxy- and epoxy-polyunsaturated fatty acids (PUFA) act as lipid mediators. In biological samples they dominantly occur esterified in phospholipids (PL). Esterified oxylipins are usually quantified indirectly after alkaline hydrolysis as non-esterified oxylipins. Here, a liquid chromatography high-resolution mass spectrometry (LC-HRMS) method for the direct analysis of oxylipins bound to PL was developed. Optimized reversed phase LC separation enabled the separation of isobaric and isomeric PL from different lipid classes bearing oxylipin positional isomers, by both the polar head groups as well as the fatty acyl chains. Each individual PL bearing oxylipins was tentatively identified based on the combination of retention time, precursor ion and specific product ions. The oxylipin was characterized based on product ions resulting from the characteristic α cleavage occurring at the hydroxy/epoxy group. Phospholipid sn 1/sn 2 isomers were identified based on the neutral loss of the fatty acyl in the sn 2 position as a ketene. A total of 422 individual oxPL species from 7 different lipid classes i.e., PI, PS, PC, PE, PC P, PC O, and PE P, bearing hydroxy- and epoxy-PUFA were detected in human serum and cells. This method was applied to investigate in which PL class supplemented oxylipins are incorporated in HEK293 cells. 153 individual oxPL species were characterized and semi-quantified using one internal standard per lipid class: 20:4;15OH, 20:4;14Ep, and 20:5;14Ep were mostly bound to PI. 20:4;8Ep and 20:5;8Ep were esterified to PC and PE while other hydroxy- and epoxy-PUFA were mainly found in PC. The developed LC-HRMS method enables the direct and comprehensive analysis of PL bearing oxylipins and to investigate their biological role.
Covid-19 vaccination acceptance among visitors of Erbil primary health care centers
Authors: Hawez Sulaiman Karwan
Published: April 2024

Background: Vaccination is probably the most effective approach to prevent and control COVID-19. Studies assessing acceptance towards vaccination showed huge regional variations.
Objective: To find out the rate of acceptance of Covid 19 vaccine and its associated factors as well as to explore out both the most frequent reasons behind acceptance or refusal of this vaccine and the most received and preferred type
Patients and Methods: In this cross-sectional study, a convenience sample of 1000 visitors to primary health care centers (PHCCs) in Erbil/Iraq, aged 18 years and older, were collected from December 2021 to December 2022. A structured questionnaire was used for data collection through a direct interview.
Results: The study showed that 43.9% of the participants accepted the vaccine. The main reason behind refusal (53.8%) was not trusting its development, while the main reasons for receiving were to protect themselves (44.2%), majority of those vaccinated (76.5%) received Pfizer, which was the most preferred type (67.4%), 10.3% of them were not completing the recommended dose and the most common reasons behind this were neglect and shortage of time (31%), and afraid from side effects (31%). A significant association found between vaccination practice with gender, education, occupation, family income and socioeconomic status. Vaccinated persons were less likely to be infected with COVID19 (20.7%) than nonvaccinated ones (62.7%).  
Conclusion: Less than half of the participants were accepted the vaccine and the acceptance rate significantly associated with male gender, education, occupation, family income, and socioeconomic status.
Enhancing Students Experience: A Comprehensive Approach through Uni-Connect
Authors:   Asst. Professor, Department of Computer Application, Lovely Professional University, Jalandhar, INDIA, Sharma Prof.Aastha , Kumar Dr.Pawan ,   Prof & Head, Department of Computer Application, Lovely Professional University, Jalandhar, INDIA
Published: April 2024

In today's digital age, university students seek comprehensive platforms that transcend basic functionalities to enrich their academic, professional, and social experiences. Inspired by this need, we propose the development of UniConnect, a dynamic web application utilizing the MERN stack. UniConnect serves as a centralized hub offering a plethora of features including user authentication, profile management, event management, job placement, real- time notifications, resource hub, project collaboration tools, peer tutoring, career assessments, and more. This paper outlines the phased development approach undertaken to realize UniConnect's vision, culminating in three distinct phases: Basic, Intermediate, and Advanced versions. Each phase incrementally enhances the platform's capabilities, focusing on functionality, usability, and user engagement. Evaluation results demonstrate the effectiveness of the UniConnect platform in meeting the diverse needs of university students, fostering collaboration, networking, and personal development. Through UniConnect, we aim to revolutionize the university experience, empowering students to thrive academically, professionally, and socially.
The Bryophyte Flora of a Collapse Doline in Niğde (Türkiye)
Authors: Keskin Ali , Ezer Tülay
Published: April 2024

In this study, the bryophyte flora of a collapse doline located in the steppe of Central Anatolia has been investigated. As a result of the identification of 365 bryophyte specimens collected from various habitats of doline, a total of 72 taxa (71mosses and 1 liverwort) belonging to 9 families and 24 genera are determined. Among them Didymodon icmadophilus is new for C13 grid-square. The most species-rich families in the study area are Pottiaceae (31 taxa), Bryaceae (13 taxa) and Grimmiaceae (11 taxa) respectively. While the widespread genera are Syntrichia (9 taxa), Didymodon (9 taxa), Ptychostomum (9 taxa) and Grimmia (6 taxa). Syntrichia ruralis, Weissia condensa, Didymodon vinealis and Orthotrichum cupulatum are the most common species in the study area.
A Bibliometric Study on The Application of Progressive Muscle Relaxation Training in The Nursing Field in China
Authors: Shi Chengwen , Zhao Feifan , Wang Yingshuo , Liu Chengxuan , Mao Aiyu , Ji Siqi , Lu Ruixiao
Published: April 2024

Objective: To systematically analyze the research status and application of progressive muscle relaxation training (PMRT) in the nursing field in China, and provide a reference basis for scientific research in this field. Methods: The bibliometric method was adopted in “progressive muscle relaxation training” or “PMRT,” and “nursing.” The established database was included in the China National Knowledge Infrastructure (CNKI) and the Wanfang Medical Network. The relevant articles in the Chinese Science and Technology Periodical Database (VIP) were analyzed. Results: A total of 169 literatures were included. The journals, years, and regions of literature publication were uneven, mainly originating from the eastern region (43.19%), and listed the application of progressive muscle relaxation training in the field of nursing in China. Intervention literature information was mainly dominated by experimental studies (97%). Conclusion: The related research and application of progressive muscle relaxation training in nursing in China is increasing, but there is a lack of objective evaluation of outcome indicators and a short intervention period. Further research should be conducted in the future to effectively guide the development of PMRT in the field of nursing in China.
Isolation, Screening, and Molecular Characterization of Rhizosphere Derived Potential Biofertilizer from Different Crops Land for Sustainable Agriculture and Environment
Authors:   Principle Scientific Officer and Officer-in-Charge, Institute of Technology Transfer and Innovation (ITTI), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Kudrat-I-Khuda Road, Dhanmondi, Dhaka-1205, Bangladesh., Karim Md. Rezaul , Hasan Md. Rakibul ,   Institute of Technology Transfer and Innovation (ITTI), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka-1205, Bangladesh., Karmakar Debabrata ,   Institute of Technology Transfer and Innovation (ITTI), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka-1205, Bangladesh., Tasnim Nishat ,   Institute of Technology Transfer and Innovation (ITTI), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka-1205, Bangladesh., Sultana Razia ,   Institute of Technology Transfer and Innovation (ITTI), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka-1205, Bangladesh., Akter Sharmin ,   Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology (JUST), Jashore-7408, Bangladesh., Hossain Md. Saddam ,   Institute of Technology Transfer and Innovation (ITTI), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhanmondi, Dhaka-1205, Bangladesh.
Published: April 2024

Overpopulation in world has created immense pressure on agricultural land to increase crops production by using excess chemical fertilizers, pesticides, and plant growth regulators. Nowadays, biofertilizer is one of the best concerns of research interest for sustainable development in agriculture and environment. About 30 soil bacteria were isolated from three different locations in Bangladesh by growing on nitrogen-free selective media and primarily had been categorized based on colony features. However, to short out the biofertilizer and biocontrol potential bacteria several assay had been conducted including nitrogen-fixing assay, ammonia production assay, phosphate solubilizing assay, IAA production assay, siderophores production assay, amylase production assay, biocontrol assay, and seed germination bioassay. Different species of Rhizobium, Bacillus, Paraburkholderia, Priestia, Arthrobacter, Pseudarthrobacter, Rhodanobacter, Flavobacterium, Mucilaginibacter, and Sphingomonas were identified by analyzing 16S rRNA gene partial sequence analysis by BLASTn that revealed many of these act as biofertilizer. Moreover, the antibiotic resistance tests of biofertilizer potential isolates and all others intensive data analysis in respect of biofertilizer functionality revealed that Paraburkholderia sacchari is the best while Priestia megaterium, Bacillus zanthoxyli, Arthrobacter globiformis, and Bacillus wiedmanni have also the potentiality to be biofertilizer. The outcome will help the researchers and industries to develop biofertilizer for crops plant.
Outbreak of invasive Group A streptococcus disease in a nursing home in Ireland in February 2023 caused by emm type 18
Authors: Carroll Ciara , Meehan Mary , Connolly Roisin , Prendergast Jayne , Magnone Colette , Meehan Aine , Migone Chantal , Quintyne Keith Ian , Carpenter Caroline , Byrne Helen , Cunney Robert , Mullane Paul
Published: April 2024

An out-of-season increase in cases of invasive Group A streptococcus (iGAS) was observed in Ireland between October 2022 and August 2023. We describe the management of an iGAS outbreak involving three nursing home residents in Ireland in early 2023. A regional Department of Public Health was notified of an iGAS case in a nursing home resident in January 2023. When two further cases among residents were notified 7 days later, an outbreak was declared. Surveillance for GAS/iGAS infection in residents and staff was undertaken. The site was visited to provide infection prevention and control (IPC) support. Isolates were emm typed. A total of 38 residents and 29 staff in contact with resident cases were provided with antibiotic chemoprophylaxis. Seven additional staff with no direct resident contact also received chemoprophylaxis after finding one probable localised GAS infection among them. No more iGAS cases subsequently occurred. Site visit recommendations included advice on terminal cleaning and cleaning of shared equipment, as well as strengthening staff education on hand hygiene and masking. All isolates were of emm subtype 18.12, a subtype not previously detected in Ireland. Key outbreak control measures were rapid delivery of IPC support and chemoprophylaxis. Emm18 is infrequently associated with GAS infections.
Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024
Authors: Bartolini Luca , Ricci Silvia , Azzari Chiara , Moriondo Maria , Nieddu Francesco , L’Erario Manuela , Ricci Zaccaria , Simonini Gabriele , Mortilla Marzia , Indolfi Giuseppe , Montagnani Carlotta , Chiappini Elena , Galli Luisa , Guerrini Renzo
Published: April 2024

A severe outbreak of influenza A(H1N1pdm09) infection in seven children (median age: 52 months) occurred between December 2023 and January 2024 in Tuscany, Italy. Clinical presentation ranged from milder encephalopathy to acute necrotizing encephalopathy (ANE) with coma and multiorgan failure; one child died. This report raises awareness for clinicians to identify and treat early acute encephalopathy caused by H1N1 influenza and serves as a reminder of severe presentations of influenza in young children and the importance of vaccination.
Contact tracing management of a measles case in a paediatric hospital: experience of the local public health unit, Portugal, January 2024
Authors: Saldanha Resendes Daniel , Tomás António , Pinção Cardoso Mariana , von Schreeb Sebastian , Miranda Ferrão Rita , Vasconcelos Paula , Almeida Maria Helena , Novo Castro Bruno , Ricoca Peixoto Vasco , Lourenço Silva Renato , de Morais Margarida
Published: April 2024

In January 2024, a child was diagnosed with measles in a paediatric hospital in Lisbon. Of 123 contacts, 39 (32%) were not fully immunised, presenting a risk for a potential outbreak. The public health unit initiated control measures and identified challenges during the response, such as the lack of interoperability between information systems and accessing vaccination records. The lessons learned prompted changes to national contact tracing procedures for measles, further strengthening Portugal’s preparedness.
Stages and Pedagogical Conditions for Forming Performance Phrasing Skills of Future Musical Art Teachers in the Process of Teaching Playing Wind Instruments
Authors: Zhan` Li
Published: April 2024

The article presents the justification of the step-by-step methodology of forming future musical art teachers’ culture of performing phrasing in the process of learning to play wind instruments. The problem of formation of the specified professional quality, which is considered as a segment of performance training that ensures the quality of the artistic-figurative disclosure of the meaning of a musical work, has been actualized. The essence and component structure of the culture of performing phrasing, which is made up of certain relevant performing skills, and the criteria for their assessment make it possible to classify three levels of their formation: high – “meaningful expressive phrasing”, medium – “aspiration for expressive phrasing”, low – “weak perception of phrasing”.

Three stages are presented, according to which the introduction of pedagogical conditions is carried out, each of which aims to positively influence the components of the culture of performing phrasing. At the first stage – motivational-setting – the pedagogical condition of stimulating a meaningful attitude towards the skills of performing phrasing is introduced, which affects the component: “motivation of artistic-technical excellence”. At the second stage – practice-oriented – such pedagogical condition is introduced as the purposeful assimilation of various forms and types of phrasing in the context of the evolution of styles and genres, which affects the component: “competence in working on the performing repertoire and musical texts of pieces”. At the third stage – self-methodological – the pedagogical condition of the activation of methodological self-efficacy in performing and educational processes is introduced, which affects the component: “artistic-communicative content of creative-performing and pedagogical interpretation of musical works for wind instruments (solo, ensemble)”.
A STRUCTURAL EQUATION MODELING WITH WELFARE INDICATORS: EXAMINING THE RELATIONSHIP BETWEEN SOCIOECONOMIC STATUS, ACCESS TO SERVICES AND MATERIAL DEPRIVATION
Authors: Bahçeci Cansu , Özdamar Öznur , Üçdoğruk Şenay , Gıovanıs Eleftherıos
Published: April 2024

This study aims at presenting comprehensive model using welfare indicators such as socioeconomic status, access to services and material deprivation, and examining the relationships between these variables. In the analysis, we use the pooled cross-sectional data set of the Household Budget Survey of the Turkish Statistical Institute (TURKSTAT) covering the period 2015-2019. Since the simultaneous relationship between welfare indicators such as socioeconomic status, material deprivation and access to services is examined using latent variables, Structural Equation Modeling is preferred. The study finds that socioeconomic status, composed of education and income, increases households' access to services and decreases their material deprivation. In addition, as households' access to services increases, their material deprivation decreases. Our study also finds that women's socioeconomic status is lower than men's in Turkiye during the period analysed. Moreover men in households have more limited access to services and face more material deprivation than women. The increase in household size makes access to services more difficult, worsens the socioeconomic situation and increases deprivation. Considering the health status variable, it is concluded that healthy individuals have higher socioeconomic status and suffer from less deprivation.
Comparative Performance Analysis of Time-Frequency Domain Images and Raw Signal Data for Classification of ECG Signals
Authors: Özseven Turgut
Published: April 2024

ECG signals are one of the most common tools used to diagnose cardiovascular diseases. ECG signals are obtained by measuring electrical changes on the skin surface. Arrhythmias occurring in the heart are diagnosed because the expert evaluates ECG signals. This diagnosis depends on the experience of the specialist and is a subjective evaluation. With the widespread use of computer-aided diagnostic systems, evaluations dependent on the expert's experience are objectified, and support is provided to the physician for diagnosis. For computer-aided ECG classification, beats are detected from ECG signals, and arrhythmias are detected by analyzing the structure of these beats. In recent years, deep learning models have been successful in classifying ECG signals. The data to be used in the classification process is realized with the help of morphological features or images of the signal. The main objective of this study is to compare the classification performance of digital and visual heartbeat data for ECG signal classification. For this purpose, 1D-CNN and 2D-CNN architectures are used for the type of ECG signals. As inputs of the 1D-CNN model, numerical values of the heartbeat signal and hand-crafted features obtained from these numerical values were used. The inputs of the 2D-CNN model are the raw signal image, spectrogram, scalogram, Mel-spectrogram, GFCC, and CQT images, which are visual representations of the heartbeat signal. The results show that the numerical model of the ECG signal fails for classification, while the hand-crafted features provide 85.2% accuracy. The results obtained with the visual representation of the signal provided over 99% classification accuracy for all images. The highest success rate was 99.9% with the visualization of the raw signal. In line with these findings, the 2D-CNN architecture and the visual representation of the heartbeat signal were found to be the most suitable method for classifying ECG signals.
Yönetim Sistemi Standartlarının İşletmelerde Uygulanması: Düzce Sanayi İşletmelerinde Bir Araştırma
Authors: Kesici Buşra , Yıldız Mehmet Selami
Published: April 2024

Bu araştırmanın temel amacı, Düzce’de faaliyet gösteren işletmelerin yönetim sistemi standartlarına sahip olma durumlarının ve öneminin ortaya konmasıdır. Nitel araştırma deseninin kullanıldığı araştırmada, veriler doküman inceleme ve görüşme teknikleri ile elde edilmiştir. Düzce’de faaliyet gösteren 57 üretim işletmesinden toplanan veriler meslek gruplarına göre kategorilere ayrılmıştır. Üretim tesislerinin içinde bulundukları sektörlere özgü gerekliliklere göre edindikleri standartlar, ISO 9001, ISO 14001, ISO 45001, IATF 16949, ISO 27001, ISO 50001, ISO 10002, ISO 13485 ve ISO 22000 olarak tanımlanmıştır. Söz konusu standartların uygulanma durumu, koşulları ve sektördeki önemli özelliklerine ait çıkarımlar yapılarak sonuçlar paylaşılmıştır.
Optimization of Surface Roughness and Cutting Temperature in Turning of 1.4534 Stainless Steel under Sustainable Conditions
Authors: Şirin Emine
Published: April 2024

1.4534 stainless steel, which is produced especially for aerospace applications, is frequently preferred in aircraft landing sets under high load and in highly corrosive environments. In addition to its superior properties, its machinability rate is low compared to other stainless steels. Moreover, improving 1.4534 stainless steel's machining performance is crucial since its formability problems. In this study, 1.4534 stainless steel was tested in a series of experiments under sustainable conditions (hBN, CO2, and hBN+CO2). Taguchi techniques were used in the experimental design to save cost and time. Three cooling levels (hBN, CO2, and hBN+CO2), three cutting speeds (140, 200, and 260 m/min), three feed rates (0.12, 0.16, and 0.20 mm/rev), and a constant cutting speed (0.8 mm) were used in the current study. Analysis of variance (ANOVA) was performed in the current study to determine the extent of the components' effects since cutting temperature and surface roughness were chosen as the performance standard. According to the test results obtained; hBN+CO2 condition showed the best performance for surface roughness and cutting temperature.
Investigation on the Effect of Parasitic Elements on PID Control of DC-DC Buck Converter
Authors: İnci Mustafa , Altun Yusuf
Published: April 2024

DC-DC converter circuits are used in many electronic devices to adjust the voltage to a certain level such as Electric Vehicle. DC-DC Buck converters, which are the most used type of DC-DC converters, reduce the input voltage and keep the output voltage constant at a desired reference voltage value. In this study, the effect of parasitic elements in Buck DC-DC converters is examined on the PID controllers. Parasitic elements cause a non-linear effect on the Buck converter system model. Studies in the literature generally control the output voltage by designing controllers on the Buck converter model without parasitic elements. Alternatively, linear controllers such as PID are designed according to the linearizing model, taking into account the effect of parasitic elements. In addition, nonlinear controllers are designed on the full model with the effect of parasitic elements. In this study, the effect of parasitic elements on linear controllers, especially PID, is examined.
Molecular Docking Study of Bioactive Compounds from Curcuma aeruginosa Roxb. as Antioxidant and Anticancer Activities
Authors: Ambarsari Laksmi , Nurjanah Siti , Artika I Made , Fatriani Rizka
Published: April 2024

Cancer is one type of dangerous disease that is increasing every year. Free radicals are the cause of gene mutations (cancer). Cancer will develop uncontrollably due to the occurrence of the cell cycle and the presence of compounds that trigger cell proliferation and inhibit the process of apoptosis. This cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. Curcuma aeruginosa RoxB., the plant, is known to have the potential for antioxidant and anticancer properties. This study aims to determine the molecular interaction between the dominant compound in the ethanol extract of C. aeruginosa with CDK2, COX-2, and LOX receptors. The type of ligand interaction with the receptor was determined through the parameters of affinity energy (∆G), inhibition constant (Ki), type of interaction, and percentage of binding site similarity (%BSS). The results showed that the gajutsulacton A had the best potential in inhibiting CDK2. The cucumenol may be a COX-2 inhibitor, and there are no compounds that can inhibit LOX as well as an antioxidant. Thus, our findings demonstrate the potential for C. aeruginosa bioactive to serve as anticancer candidate molecules against CDK2 and COX-2 receptors.
Rinorrea de líquido cefalorraquídeo secundaria a carcinoma etmoidal: reporte de caso
Authors: García-López Bryan Eduardo , Mondragón-García Diana , Morán-Domínguez Abigail , Sánchez-Pérez Itzel Yoselin , Velázquez-Sámano Guillermo , Velasco-Medina Andrea Aída
Published: April 2024

Abstract
Background
The first report of cerebrospinal fluid rhinorrhea (CSFR) was described in 1679. In 1826 it was reported that one of the possible causes of CSFR was a fistula between the subarachnoid space and the nasal cavity. In 1903, chemical analysis of the fluid was proposed as a diagnostic criterion. In Mexico there has been 32 case reports.
Case report. Forty-nine years old female with a history of nasal polyposis, profuse rhinorrhea and cephalea who attends the allergy department with the suspicion of allergic rhinitis. After anamnesis and physical evaluation, CSFR was suspected. Chemical analysis of the fluid, head CT and biopsy of nasal polyp were performed. An etmoidal fistula associated with carcinoma was confirmed.
Discussion and conclusions. Spontaneous fistulas are rare but can erosionate the bone and adjacent tissues. Diagnosis is based on the clinical findings, patient’s history and complementary studies such as beta-2-transferrin determination in nasal fluid.
Loxoscelismo con síndrome compartimental agudo: reporte de un caso con desenlace exitoso
Authors: Sánchez-Pérez Itzel Yoselin , Chávez- Ríos Yareni , Moreno- Hernández Sergio Gerardo , Velasco-Medina Andrea , Velázquez-Samano Guillermo Velázquez-Sámano , Ramos-Martínez Espiridión
Published: April 2024

Antecedentes: El loxoscelismo es un cuadro clínico tóxico provocado por la mordedura de arañas del género Loxosceles, con amplia distribución en todo el mundo.1 La fosfolipasa D es la responsable de la dermonecrosis, inflamación, agregación plaquetaria, hemólisis, alteración de la permeabilidad vascular, citotoxicidad, nefrotoxicidad, insuficiencia renal aguda, entre otros síntomas implicados con esta proteína.
Reporte de caso: Paciente masculino de 27 años, que inició con un cuadro repentino de dolor intenso en la mano derecha, en el metacarpo y las articulaciones metacarpofalángicas. Al examen clínico, la extremidad superior se percibió con aumento de volumen, edema extenso, hiperemia y aumento de la temperatura local; la lesión progresó a necrosis extensa. Se realizaron fasciotomías, de distal a proximal, y liberación del compartimento del segundo y tercer dedo a través de incisiones longitudinales radiales y cubitales. Se colocó un autoinjerto de piel, obtenido de la superficie anterior del muslo derecho. Se administraron analgésicos opioides, antiinflamatorios no esteroides, corticosteroides y antibióticos. La biopsia de piel reporto: infiltrado inflamatorio con neutrófilos, ulceración y colonias bacterianas. Luego de 27 días tuvo evolución favorable, por lo que se dio alta a su domicilio, con seguimiento por personal del servicio de Consulta externa.
Conclusión: El loxoscelismo cutáneo, como causa de síndrome compartimental agudo de la mano, es poco común, pero debe considerarse en un área endémica para Loxosceles spp. La descompresión quirúrgica de los compartimentos afectados representa un factor decisivo en el tratamiento de los pacientes.
Inflammaging en pacientes con Fibrosis pulmonar idiopática (FPI).
Authors: Rodríguez Rodríguez Ivon , Mesa Gallo Brayan Leonardo , Rico Puentes Yubely , González Mauricio , Parra López Carlos Alberto
Published: April 2024

Background: Chronic lung pathologies represent a mortality burden on older adults. Specifically, idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial disease with a prevalence that increases linearly with age. Immune aging has been characterized by increased circulating proinflammatory cytokines that can facilitate pathological remodeling and tissue fibrosis. In this context, there can be a connection between the cytokine profile and diseases such as IPF.
Aim: To identify proinflammatory cytokines in the plasma of patients with IPF residing in the Bogotá area.
Materials and methods: We took Peripheral blood samples from healthy adults and patients over 60 years of age with a confirmed diagnosis of IPF through biopsy or clinical criteria. We measure proinflammatory cytokines in plasma using CBA. This study received approval from the ethics and research committee of the Fundación Neumologica Colombiana.
Results: Patients with IPF exhibited increased cytokines such as IL-4, INFy, and IL-6 compared to healthy older adults.
Conclusion: Inflammatory disease has been associated with the development and coexistence of multiple chronic non-communicable diseases that have a higher incidence after 65 years old. The involvement of adaptive immunity in the pathogenesis of IPF has been described as an imbalance in the Th1/Th2 lymphocyte response. Further studies are required to identify additional markers of immunosenescence that correlate with IPF.
Reactividad IgE de sueros en pacientes con enfermedades autoinmunes, frente a una proteína multi-epítopes construida a partir de epítopes T de alérgenos de Ascaris lumbricoides
Authors: Fang Luis , Martínez Dalgys , Meza-Torres Catherine , Moreno-Woo Ana , Pereira-Sanandres Nicole , Dominguez-Vargas Alex , Garavito Gloria , Egea Eduardo
Published: April 2024

Background:
Helminth infections for Ascaris lumbricoides and exposure to mite allergens stimulate a Th2 immune response present in allergic diseases. Helminth proteins are well known can modulate the host immune response and lessen the inflammation response. We evaluate the Ig E reactivity to a molecule constructed from A. lumbricoides T epitopes (MP1) in sera from patients suffering from T1D, LN, and JIA
Methods:
We designed and expressed a synthetic multi-epítope protein named MP1 from A. lumbricoides and house dust mites allergens. By indirect ELISA, we evaluated IgE-reactivity to MP1 and to the whole-body extract of Ascaris lumbricoidesin 45 sera from Colombian Caribbean patients with lupus nephritis (LN; n=25), type 1 diabetes (T1D; n=10) and Juvenil idiopathic arthritis (JIA; n=10). Individuals with poly autoimmunity were excluded. All patients were referred to the study by their specialist doctor.
Results:
IgE to whole-body extract of A. lumbricoides showed the following median concentrations: 484.2 ng/ml (IQR: 203.4) in JIA patients, 325.6 ng/ml (IQR: 179.3) in individuals with LN, and 424.7 ng/ml (IQR: 80.1) in T1D group. On the other hand, IgE-reactivity to MP1 was 126.4 ng/ml (IQR: 90.9) in JIA patients, 130.7 ng/ml (IQR: 94.8) in an individual with LN, and 148.8 ng/ml (IQR: 102.1) in T1D group. Although no statistical differences were observed between patient groups, the IgE to MP1 in all patients (n: 45) (IgE median: 134.2 ng/ml; IQR: 100) were significantly less compared to Ascaris extract (IgE median: 380.7 ng/ml; IQR: 175.8); (W:0.732; p-value: 1.034x10-7).
Conclusions:
These preliminary results suggest that MP1 showed antigenic properties with low IgE-reactivity compared to Ascaris lumbricoides extract in individuals with autoimmune diseases. Further studies are needed to understand better the immune response induced by this molecule.
Atos de fala e a relevância social de propagandas de cosméticos na construção da identidade da mulher negra
Authors: Souza Fabiana Santos
Published: April 2024

O presente estudo objetiva estabelecer e pensar a relação entre linguagem midiática e a construção de identidade por meio de atos de fala e dos jogos de linguagem, considerando-os como atos políticos.
Perfil epidemiológico das emergências oftalmológicas pediátricas no Brasil entre 2019 e 2023.
Authors: Rezende Heitor Martins , Silva Wesley do Nascimento , Rocha Mayara Regina Fontinele , Uchôa Alexandre Magno Rodrigues
Published: April 2024

Introdução: A saúde ocular é crucial para o desenvolvimento e bem-estar das crianças. As perfurações de globo ocular, por exemplo, são causa importante de incapacidade funcional, sendo a casa do pacie
Riscos e adequações para envenenamento infantil por produtos e por artigos domésticos químicos.
Authors: Medeiros Maria Eduarda Santos , Silva Paula Leonara Da , Rocha Marcella Zica , Castanheira Luiza
Published: April 2024

Com este relato de caso propõe-se uma afirmativa acerca da intoxicação infantil por meio da ingestão de materiais domésticos de limpeza em que a gravidade possa ser classificada como emergência. Somad
PATRIMÔNIO ARQUITETÔNICO, NORMAS E FORMAS DE PROPOR ACESSIBILIDADE EM OBJETOS TOMBADOS
Authors: MARTINS MARIA JULIA AVELINO SILVA , FERNANDES FABRICIA DIAS DA CUNHA DE MORAES
Published: April 2024

Acessibilidade é permitir que um local tenha livre circulação a todos os públicos, incluindo as pessoas com limitações de movimentos, ou mobilidade reduzida, visando permitir uma interação comum. Cont
Atlas de Bolso de Anatomia Humana III
Authors: Machado Camila Zanetti , Azizi Marco Antônio Alves , Condé Gabrielle Mendonça , Azevedo Tito Vidal Oliveira de , Mello Esther Victoria Lima de , Mourão Luma Chan , Meirelles Larissa Monteiro de , Alvim Eduarda Reis da Rocha Villalba , Silva Cassio Eduardo dos Santos , Vicini Juliana Rosa , Witte Bruna Rambo , Souza Lucas Gomes de , Gonçalves Taylane Guimaraes , Coelho Karen de Oliveira , Póvoa Maria Carolina Ramos , Santos Ludmilla Pimentel , Alvarenga Enrico Casini , Massimiliani Lorenza Eccard , Sá Luiz Felipe Barbosa de , Faria Pedro Caetano de Mesquita Diniz de
Published: April 2024

O Atlas de Bolso de Anatomia Humana III, produzido pelos alunos da Liga de Anatomia Humana da Universidade de Nova Iguaçu Campus I, destaca-se por apresentar imagens de peças reais, oferecendo uma visão autêntica e realista da neuroanatomia, contento conteúdo acadêmico de anatomia de cérebro, tronco encefálico e cerebelo. Desenvolvido com dedicação e empenho, o atlas combina informações concisas com imagens de alta qualidade, proporcionando uma ferramenta didática completa para estudantes e profissionais da área da saúde. Além de seu valor acadêmico, o atlas reflete o comprometimento dos alunos em compartilhar conhecimento anatômico de maneira acessível, tornando-se uma contribuição significativa para a comunidade acadêmica. Conta ainda com questões de anatomia de concursos de anatomia 1, 2 e 3, com gabarito.