bluuebunny/crossref_metadata_2025 huggingface dataset:
Ferroelectric Polarization in an h-BN-Encapsulated 30°-Twisted Bilayer–Graphene Heterostructure
Authors: Ren Lingling , Dong Baojuan
Published: April 2023

Recently, the emergent two-dimensional (2D) ferroelectric materials have provided new possibilities for the miniaturization of ferroelectric systems and the integration of novel 2D nano-electronic devices. In addition to the intrinsic ferroelectrics exfoliated from bulk, 2D heterostructures hybridized from electrically non-polarized van der Waals (vdW) materials have also been proven to be a promising platform for the construction of ferroelectricity. Here, we report 30° twisted bilayer–graphene (TBLG) incommensurate moiré superlattice encapsulated by hexagonal boron nitride (h-BN), in which robust hysteretic resistance was detected at the top interface between h-BN and the TBLG from room temperature down to 40 mK. The hysteretic phenomenon can be understood by the extra carrier induced by the interfacial 2D ferroelectric polarization, which is estimated to be around 0.7 pC/m. Our work of interfacial ferroelectric heterostructure achieved by a TBLG/h-BN hybrid system expands the 2D ferroelectric families and opens more possibilities for future coupling the ferroelectricity with rich electronic and optical properties in vdW twistronic devices.
Analytic Study of Coupled Burgers’ Equation
Authors: Cesarano Clemente , Massoun Youssouf , Said Abderrezak , Talbi Mohamed Elamine
Published: April 2023

In this paper, we construct an analytical solution of the coupled Burgers’ equation, using the homotopy analysis method, which is a semi-analytical method, the approximate solution obtained by this method is convergent for different values of the convergence control parameter ℏ, the optimal value of ℏ corresponding with the minimum error to be determined by the residual. The results obtained by the present method are compared with other obtained solutions by different numerical methods.
Proliferative Effect of Aqueous Extract of Sea Cucumber (Holothuria parva) Body Wall on Human Umbilical Cord Mesenchymal Stromal/Stem Cells
Authors: Rasekh Poorya , Kameli Ali , Khoradmehr Arezoo , Baghban Neda , Mohebbi Gholamhossein , Barmak Alireza , Nabipour Iraj , Azari Hossein , Heidari Yaser , Daneshi Adel , Bargahi Afshar , Khodabandeh Zahra , Zare Shahrokh , Afshar Alireza , Shirazi Reza , Almasi-Turk Sahar , Tamadon Amin
Published: April 2023

Sea cucumber extracts and their bioactive compounds have the potential for stem cell proliferation induction and for their beneficial therapeutic properties. In this study, human umbilical cord mesenchymal stromal/stem cells (hUC-MSCs) were exposed to an aqueous extract of Holothuria parva body walls. Proliferative molecules were detected using gas chromatography-mass spectrometry (GC-MS) analysis in an aqueous extract of H. parva. The aqueous extract concentrations of 5, 10, 20, 40, and 80 µg/mL and 10 and 20 ng/mL of human epidermal growth factor (EGF) as positive controls were treated on hUC-MSCs. MTT, cell count, viability, and cell cycle assays were performed. Using Western blot analysis, the effects of extracts of H. parva and EGF on cell proliferation markers were detected. Computational modeling was done to detect effective proliferative compounds in the aqueous extract of H. parva. A MTT assay showed that the 10, 20, and 40 µg/mL aqueous extract of H. parva had a proliferative effect on hUC-MSCs. The cell count, which was treated with a 20 µg/mL concentration, increased faster and higher than the control group (p < 0.05). This concentration of the extract did not have a significant effect on hUC-MSCs’ viability. The cell cycle assay of hUC-MSCs showed that the percentage of cells in the G2 stage of the extract was biologically higher than the control group. Expression of cyclin D1, cyclin D3, cyclin E, HIF-1α, and TERT was increased compared with the control group. Moreover, expression of p21 and PCNA decreased after treating hUC-MSCs with the extract. However, CDC-2/cdk-1 and ERK1/2 had almost the same expression as the control group. The expression of CDK-4 and CDK-6 decreased after treatment. Between the detected compounds, 1-methyl-4-(1-methyl phenyl)-benzene showed better affinity to CDK-4 and p21 than tetradecanoic acid. The H. parva aqueous extract showed proliferative potential on hUC-MSCs.
Biochemical Characteristics and Potential Biomedical Applications of Hydrolyzed Carrageenans
Authors: Humayun Sanjida , Premarathna Amal D. , Rjabovs Vitalijs , Howlader Md Musa , Darko Clarisa Naa Shormeh , Mok Il-Kyoon , Tuvikene Rando
Published: April 2023

Seaweed contains a variety of bioactive compounds; the most abundant of them are polysaccharides, which have significant biological and chemical importance. Although algal polysaccharides, especially the sulfated polysaccharides, have great potential in the pharmaceutical, medical and cosmeceutical sectors, the large molecular size often limits their industrial applications. The current study aims to determine the bioactivities of degraded red algal polysaccharides by several in vitro experiments. The molecular weight was determined by size-exclusion chromatography (SEC), and the structure was confirmed by FTIR and NMR. In comparison to the original furcellaran, the furcellaran with lower molecular weight had higher OH scavenging activities. The reduction in molecular weight of the sulfated polysaccharides resulted in a significant decrease in anticoagulant activities. Tyrosinase inhibition improved 2.5 times for hydrolyzed furcellaran. The alamarBlue assay was used to determine the effects of different Mw of furcellaran, κ-carrageenan and ι-carrageenan on the cell viability of RAW264.7, HDF and HaCaT cell lines. It was found that hydrolyzed κ-carrageenan and ι-carrageenan enhanced cell proliferation and improved wound healing, whereas hydrolyzed furcellaran did not affect cell proliferation in any of the cell lines. Nitric oxide (NO) production decreased sequentially as the Mw of the polysaccharides decreased, which indicates that hydrolyzed κ-Carrageenan, ι-carrageenan and furcellaran have the potential to treat inflammatory disease. These findings suggested that the bioactivities of polysaccharides were highly dependent on their Mw, and the hydrolyzed carrageenans could be used in new drug development as well as cosmeceutical applications.
Anti-Diabetic Activity of a Novel Exopolysaccharide Produced by the Mangrove Endophytic Fungus Penicillium janthinellum N29
Authors: Shao Zhuling , Tian Yingying , Liu Shan , Chu Xiao , Mao Wenjun
Published: April 2023

Marine microorganisms often produce exopolysaccharides with novel structures and diverse biological activities due to their specific marine environment. The novel active exopolysaccharides from marine microorganisms have become an important research area in new drug discovery, and show enormous development prospects. In the present study, a homogeneous exopolysaccharide from the fermented broth of the mangrove endophytic fungus Penicillium janthinellum N29, designated as PJ1-1, was obtained. The results of chemical and spectroscopic analyses showed that PJ1-1 was a novel galactomannan with a molecular weight of about 10.24 kDa. The backbone of PJ1-1 was composed of →2)-α-d-Manp-(1→, →4)-α-d-Manp-(1→, →3)-β-d-Galf-(1→ and →2)-β-d-Galf-(1→ units with partial glycosylation at C-3 of →2)-β-d-Galf-(1→ unit. PJ1-1 had a strong hypoglycemic activity in vitro, evaluated using the assay of α-glucosidase inhibition. The anti-diabetic effect of PJ1-1 in vivo was further investigated using mice with type 2 diabetes mellitus induced by a high-fat diet and streptozotocin. The results indicated that PJ1-1 markedly reduced blood glucose level and improved glucose tolerance. Notably, PJ1-1 increased insulin sensitivity and ameliorated insulin resistance. Moreover, PJ1-1 significantly decreased the levels of serum total cholesterol, triglyceride and low-density lipoprotein cholesterol, enhanced the level of serum high-density lipoprotein cholesterol and alleviated dyslipidemia. These results revealed that PJ1-1 could be a potential source of anti-diabetic agent.
Anti-Viral Surfaces in the Fight against the Spread of Coronaviruses
Authors: Kwiatkowska Angelika , Granicka Ludomira
Published: April 2023

This review is conducted against the background of nanotechnology, which provides us with a chance to effectively combat the spread of coronaviruses, and which primarily concerns polyelectrolytes and their usability for obtaining protective function against viruses and as carriers for anti-viral agents, vaccine adjuvants, and, in particular, direct anti-viral activity. This review covers nanomembranes in the form of nano-coatings or nanoparticles built of natural or synthetic polyelectrolytes––either alone or else as nanocomposites for creating an interface with viruses. There are not a wide variety of polyelectrolytes with direct activity against SARS-CoV-2, but materials that are effective in virucidal evaluations against HIV, SARS-CoV, and MERS-CoV are taken into account as potentially active against SARS-CoV-2. Developing new approaches to materials as interfaces with viruses will continue to be relevant in the future.
Advances in Antimicrobial Peptide Discovery via Machine Learning and Delivery via Nanotechnology
Authors: Sowers Alexa , Wang Guangshun , Xing Malcolm , Li Bingyun
Published: April 2023

Antimicrobial peptides (AMPs) have been investigated for their potential use as an alternative to antibiotics due to the increased demand for new antimicrobial agents. AMPs, widely found in nature and obtained from microorganisms, have a broad range of antimicrobial protection, allowing them to be applied in the treatment of infections caused by various pathogenic microorganisms. Since these peptides are primarily cationic, they prefer anionic bacterial membranes due to electrostatic interactions. However, the applications of AMPs are currently limited owing to their hemolytic activity, poor bioavailability, degradation from proteolytic enzymes, and high-cost production. To overcome these limitations, nanotechnology has been used to improve AMP bioavailability, permeation across barriers, and/or protection against degradation. In addition, machine learning has been investigated due to its time-saving and cost-effective algorithms to predict AMPs. There are numerous databases available to train machine learning models. In this review, we focus on nanotechnology approaches for AMP delivery and advances in AMP design via machine learning. The AMP sources, classification, structures, antimicrobial mechanisms, their role in diseases, peptide engineering technologies, currently available databases, and machine learning techniques used to predict AMPs with minimal toxicity are discussed in detail.
Phosphate Solubilization and Plant Growth Promotion by Pantoea brenneri Soil Isolates
Authors: Suleimanova Aliya , Bulmakova Daria , Sokolnikova Lidiya , Egorova Evgenia , Itkina Daria , Kuzminova Olga , Gizatullina Albina , Sharipova Margarita
Published: April 2023

Phosphate solubilizing microorganisms (PSMs) in soil have been shown to reduce mineral phosphate fertilizer supplementation and promote plant growth. Nevertheless, only several P-solubilizing microorganisms capable of solubilizing both organic and mineral sources of soil phosphorus have been identified up to now. The aim of this study was to evaluate the inorganic soil phosphate solubilizing activity of phytate-hydrolyzing Pantoea brenneri soil isolates. We showed that the strains efficiently solubilize a variety of inorganic phosphates. We optimized the media composition and culturing conditions to improve the solubilization efficiency of the strains and investigated the mechanisms of their phosphate solubilization. Through HPLC analysis, it was determined that P. brenneri produce oxalic, malic, formic, malonic, lactic, maleic, acetic, and citric acids as well as acid and alkaline phosphatases while growing on insoluble phosphate sources. Finally, we analyzed the influence of P. brenneri strains with multiple PGP-treats on plant growth in greenhouse experiments and showed their ability to promote growth of potato.
Human Orf with Immune-Mediated Reactions: A Systematic Review
Authors: Rossi Luca , Tiecco Giorgio , Venturini Marina , Castelli Francesco , Quiros-Roldan Eugenia
Published: April 2023

Background: Orf is a highly contagious zoonosis caused by Orf virus (ORFV), which is endemic in sheep and goats worldwide. Human Orf is usually a self-limiting disease, but potential complications, including immune-mediated reactions, may occur. Methods: We included all articles regarding Orf-associated immunological complications published in peer-reviewed medical journals. We conducted a literature search of the United States National Library of Medicine, PubMed, MEDLINE, PubMed Central, PMC, and the Cochrane Controlled Trials. Results: A total of 16 articles and 44 patients were included, prevalently Caucasian (22, 95.7%) and female (22, 57.9%). The prevailing immunological reaction was erythema multiforme (26, 59.1%), followed by bullous pemphigoid (7, 15.9%). In most cases, the diagnosis was made on the basis of clinical and epidemiological history (29, 65.9%), while a biopsy of secondary lesions was performed in 15 patients (34.1%). A total of 12 (27.3%) patients received a local or systemic treatment for primary lesions. Surgical removal of primary lesion was described in two cases (4.5%). Orf-immune-mediated reactions were treated in 22 cases (50.0%), mostly with topical corticosteroids (12, 70.6%). Clinical improvement was reported for all cases. Conclusions: Orf-related immune reactions can have a varied clinical presentation, and it is important for clinicians to be aware of this in order to make a prompt diagnosis. The main highlight of our work is the presentation of complicated Orf from an infectious diseases specialist’s point of view. A better understanding of the disease and its complications is essential to achieve the correct management of cases.
Leading Pathogens Involved in Co-Infection and Super-Infection with COVID-19: Forensic Medicine Considerations after a Systematic Review and Meta-Analysis
Authors: Scendoni Roberto , Bury Emanuele , Lima Arrais Ribeiro Isabella , Cingolani Mariano , Cameriere Roberto , De Benedictis Anna , De Micco Francesco
Published: April 2023

The COVID-19 pandemic raised concerns about the potential for co-infection or over-infection with other respiratory infections, as they can complicate the diagnosis, treatment and prognosis of the disease. This is also a challenge for forensic pathologists, who may come across cases where the presence of co-infection or over-infection is suspected or confirmed, and it is important that they take this into account when determining the cause of death. The aim of this systematic review is to analyse the prevalence of each specific pathogen co-infecting or over-infecting patients with SARS-CoV-2 infection. In total, 575 studies were selected from the Scopus and Pub-Med online databases and 8 studies were included in a meta-analysis. Male gender, advanced age and nursing home care are risk factors associated with the development of co-infection, whereas age, tachypnoea, hypoxaemia and bacterial infection are predictors of mortality. Overall, however, having a SARS-CoV-2 infection does not represent a real risk for the development of co-infections/super-infections.
Frequency-Selective Surface Based on Negative-Group-Delay Bismuth–Mica Medium
Authors: Zaitsev Anton D. , Demchenko Petr S. , Kablukova Natallya S. , Vozianova Anna V. , Khodzitsky Mikhail K.
Published: April 2023

Negative group delay may be observed in dispersive media with anomalous dispersion in a certain frequency range. The fact that an outgoing wave packet precedes an incoming one does not violate the causality principle but is only a consequence of a waveform reshaping. This effect is observed in media such as photonic crystals, hyperbolic and epsilon-near-zero metamaterials, undersized waveguides, subwavelength apertures, side-by-side prisms, and resonant circuits at various frequencies. The current work is devoted to the design of a simple negative-group-delay medium with tunable properties in the THz frequency range. This medium consists of a bismuth-based frequency-selective surface on a dielectric substrate and may be tuned both statically and dynamically. While a geometry variation defines a main form of an effective permittivity dispersion and group delay/group velocity spectra, an external voltage allows one to adjust them with high precision. For the configuration proposed in this work, all frequency regions with noticeable change in group delay/group velocity lie within atmospheric transparency windows, which are to be used in 6G communications. This medium may be applied to THz photonics for a tunable phase-shift compensation, dispersion management in systems of THz signal modulation, and for encoding in next-generation wireless communication systems.
Valorization of Pennisetum setaceum: From Invasive Plant to Fiber Reinforcement of Injected Composites
Authors: Cabrera-García Patricia , Marrero María Dolores , Benítez Antonio Nizardo , Paz Rubén
Published: April 2023

During the control campaigns of Pennisetum setaceum (invasive species widespread worldwide), the generated waste has accumulated in landfills. This study investigates its use to obtain P. setaceum fibers for their application as reinforcement of polymeric materials for injection molding, thus facilitating and promoting alternatives for the long-term sustainable management of P. setaceum. The extracted fibers were treated with alkaline, silane, acetic acid, and combined alkaline and silane treatments. Different composites with 20 and 40 wt% of fiber were extruded, and test samples were obtained by injection molding using recycled polyethylene as matrix. The composition of the fibers was determined by gravimetric methods, and contrasted with the analysis of the functional chemical groups using Fourier Transform Infrared Spectroscopy. Increases of up to 47% in the cellulose content of the treated fiber were observed. The thermal degradation was also evaluated using thermogravimetric analysis, which determined an increase in the degradation temperature, from 194 to 230 °C, after the combined alkaline–silane treatment. In order to analyze the differences in the composites, tensile, flexural, and impact properties were evaluated; in addition, differential scanning calorimetry was performed. Regarding the flexural behavior, it was possible to improve the flexural modulus up to 276% compared with that of the unreinforced polymer.
Modulation of the Berry Skin Transcriptome of cv. Tempranillo Induced by Water Stress Levels
Authors: Carvalho Luísa C. , Ramos Miguel J. N. , Faísca-Silva David , Marreiros Pedro , Fernandes João C. , Egipto Ricardo , Lopes Carlos M. , Amâncio Sara
Published: April 2023

Climate change in the Mediterranean area is making summers warmer and dryer. Grapevine (Vitis vinifera L.) is mostly important for wine production in Mediterranean countries, and the variety Tempranillo is one of the most cultivated in Spain and Portugal. Drought decreases yield and quality and causes important economic losses. As full irrigation has negative effects on quality and water is scarce in this region, deficit irrigation is often applied. In this research, we studied the effects of two deficit irrigation treatments, Sustained Deficit Irrigation (SDI) and Regulated Deficit Irrigation (RDI), on the transcriptome of grape berries at full maturation, through RNAseq. The expression of differentially regulated genes (DEGs) was also monitored through RT-qPCR along berry development. Most transcripts were regulated by water stress, with a similar distribution of up- and down-regulated transcripts within functional categories (FC). Primary metabolism was the more severely affected FC under water stress, followed by signaling and transport. Almost all DEGs monitored were significantly up-regulated by severe water stress at veraison. The modulation of an auxin response repression factor, AUX22D, by water stress indicates a role of this gene in the response to drought. Further, the expression of WRKY40, a TF that regulates anthocyanin biosynthesis, may be responsible for changes in grape quality under severe water stress.
In Depth Topological Analysis of Arabidopsis Mid-SUN Proteins and Their Interaction with the Membrane-Bound Transcription Factor MaMYB
Authors: Andov Bisa , Boulaflous-Stevens Aurelia , Pain Charlotte , Mermet Sarah , Voisin Maxime , Charrondiere Camille , Vanrobays Emmanuel , Tutois Sylvie , Evans David E. , Kriechbaumer Verena , Tatout Christophe , Graumann Katja
Published: April 2023

Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals, and fungi. Previous higher plant studies have associated them with functions at the nuclear envelope and the endoplasmic reticulum (ER). In this study, high-resolution confocal light microscopy is used to explore the localisation of SUN3 and SUN4 in the perinuclear region, to explore topology, and to study the role of mid-SUNs on endoplasmic reticulum morphology. The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. The results highlight the importance of mid-SUNs as functional components of the ER and outer nuclear membrane.
Development and Analysis of a Distributed Leak Detection and Localisation System for Crude Oil Pipelines
Authors: Ahmed Safuriyawu , Le Mouël Frédéric , Stouls Nicolas , Lipeme Kouyi Gislain
Published: April 2023

Crude oil leakages and spills (OLS) are some of the problems attributed to pipeline failures in the oil and gas industry’s midstream sector. Consequently, they are monitored via several leakage detection and localisation techniques (LDTs) comprising classical methods and, recently, Internet of Things (IoT)-based systems via wireless sensor networks (WSNs). Although the latter techniques are proven to be more efficient, they are susceptible to other types of failures such as high false alarms or single point of failure (SPOF) due to their centralised implementations. Therefore, in this work, we present a hybrid distributed leakage detection and localisation technique (HyDiLLEch), which combines multiple classical LDTs. The technique is implemented in two versions, a single-hop and a double-hop version. The evaluation of the results is based on the resilience to SPOFs, the accuracy of detection and localisation, and communication efficiency. The results obtained from the placement strategy and the distributed spatial data correlation include increased sensitivity to leakage detection and localisation and the elimination of the SPOF related to the centralised LDTs by increasing the number of node-detecting and localising (NDL) leakages to four and six in the single-hop and double-hop versions, respectively. In addition, the accuracy of leakages is improved from 0 to 32 m in nodes that were physically close to the leakage points while keeping the communication overhead minimal.
SM2-Based Offline/Online Efficient Data Integrity Verification Scheme for Multiple Application Scenarios
Authors: Li Xiuguang , Yi Zhengge , Li Ruifeng , Wang Xu-An , Li Hui , Yang Xiaoyuan
Published: April 2023

With the rapid development of cloud storage and cloud computing technology, users tend to store data in the cloud for more convenient services. In order to ensure the integrity of cloud data, scholars have proposed cloud data integrity verification schemes to protect users’ data security. The storage environment of the Internet of Things, in terms of big data and medical big data, demonstrates a stronger demand for data integrity verification schemes, but at the same time, the comprehensive function of data integrity verification schemes is required to be higher. Existing data integrity verification schemes are mostly applied in the cloud storage environment but cannot successfully be applied to the environment of the Internet of Things in the context of big data storage and medical big data storage. To solve this problem when combined with the characteristics and requirements of Internet of Things data storage and medical data storage, we designed an SM2-based offline/online efficient data integrity verification scheme. The resulting scheme uses the SM4 block cryptography algorithm to protect the privacy of the data content and uses a dynamic hash table to realize the dynamic updating of data. Based on the SM2 signature algorithm, the scheme can also realize offline tag generation and batch audits, reducing the computational burden of users. In security proof and efficiency analysis, the scheme has proven to be safe and efficient and can be used in a variety of application scenarios.
High-Dynamic-Range Spectral Reflectance for the Segmentation of Paint Pigment: Application to Dalí’s Oil Painting Dos Figuras (1926)
Authors: Fernandez-Balbuena Antonio Alvarez , Gómez-Manzanares Angela , Martínez Antón Juan Carlos , Gómez-Tejedor Jorge García , Mayorga-Pinilla Santiago , Durán Roque Humberto , Vázquez Moliní Daniel
Published: April 2023

Restorers and curators in museums sometimes find it difficult to accurately segment areas of paintings that have been contaminated with other pigments or areas that need to be restored, and work on the painting needs to be carried out with minimum possible damage. It is therefore necessary to develop measurement systems and methods that facilitate this task in the least invasive way possible. The aim of this study was to obtain high-dynamic-range (HDR) spectral reflectance and spatial resolution for Dalí’s painting entitled Two Figures (1926) in order to segment a small area of black and white pigment that was affected by the contact transfer of reddish pigment from another painting. Using Hypermatrixcam to measure the HDR spectral reflectance developed by this research team, an HDR multispectral cube of 12 images was obtained for the band 470–690 nm in steps of 20 nm. With the values obtained for the spectral reflectance of the HDR cube, the colour of the area of paint affected by the transfer was studied by calculating the a*b* components with the CIELab system. These a*b* values were then used to define two methods of segmenting the exact areas in which there was a transfer of reddish pigment. The area studied in the painting was originally black, and the contamination with reddish pigment occupied 13.87% to 32% of the total area depending on the selected method. These different solutions can be explained because the lower limit is segmentation based on pure pigment and the upper limit considers red as an exclusion of non-black pigment. Over- and under-segmentation is a common problem described in the literature related to pigment selection. In this application case, as red pigment is not original and should be removed, curators will choose the method that selects the highest red area.
Deep SE-BiLSTM with IFPOA Fine-Tuning for Human Activity Recognition Using Mobile and Wearable Sensors
Authors: Jameer Shaik , Syed Hussain
Published: April 2023

Pervasive computing, human–computer interaction, human behavior analysis, and human activity recognition (HAR) fields have grown significantly. Deep learning (DL)-based techniques have recently been effectively used to predict various human actions using time series data from wearable sensors and mobile devices. The management of time series data remains difficult for DL-based techniques, despite their excellent performance in activity detection. Time series data still has several problems, such as difficulties in heavily biased data and feature extraction. For HAR, an ensemble of Deep SqueezeNet (SE) and bidirectional long short-term memory (BiLSTM) with improved flower pollination optimization algorithm (IFPOA) is designed to construct a reliable classification model utilizing wearable sensor data in this research. The significant features are extracted automatically from the raw sensor data by multi-branch SE-BiLSTM. The model can learn both short-term dependencies and long-term features in sequential data due to SqueezeNet and BiLSTM. The different temporal local dependencies are captured effectively by the proposed model, enhancing the feature extraction process. The hyperparameters of the BiLSTM network are optimized by the IFPOA. The model performance is analyzed using three benchmark datasets: MHEALTH, KU-HAR, and PAMPA2. The proposed model has achieved 99.98%, 99.76%, and 99.54% accuracies on MHEALTH, KU-HAR, and PAMPA2 datasets, respectively. The proposed model performs better than other approaches from the obtained experimental results. The suggested model delivers competitive results compared to state-of-the-art techniques, according to experimental results on four publicly accessible datasets.
Artificial Intelligence for Media Ecological Integration and Knowledge Management
Authors: Balaram Allam , Kannan K Nattar , Čepová Lenka , Kumar M Kishore , Rani B Swaroopa , Schindlerova Vladimira
Published: April 2023

Information Technology’s development increases day by day, making life easier in terms of work and progress. In these developments, knowledge management is becoming mandatory in all the developing sectors. However, the conventional model for growth analysis in organizations is tedious as data are maintained in ledgers, making the process time consuming. Media Ecology, a new trending technology, overcomes this drawback by being integrated with artificial intelligence. Various sectors implement this integrated technology. The marketing strategy of Huawei Technologies Co. Ltd. is analyzed in this research to examine the advantages of Media Ecology Technology in integration with artificial intelligence and a Knowledge Management Model. This combined model supports sensor technology by considering each medium, the data processing zone, and user location as nodes. A Q-R hybrid simulation methodology is implemented to analyze the data collected through Media Ecology. The proposed method is compared with the inventory model, and the results show that the proposed system provides increased profit to the organization. Paying complete attention to Artificial intelligence without the help of lightweight deep learning models is impossible. Thus, lightweight deep models have been introduced in most situations, such as healthcare management, maintenance systems, and controlling a few IoT devices. With the support of high-power consumption as computational energy, it adapts to lightweight devices such as mobile phones. One common expectation from the deep learning concept is to develop an optimal structure in case time management.
Introduction of the Personal Domain in Water Sanitation and Hygiene (WASH), a New Approach to Identify Missing Health Impacts
Authors: Jensen Peter Kjær Mackie , Hossain Zenat Zebin , Sultana Rebeca , Ferdous Jannatul , Almeida Sara , Begum Anowara
Published: April 2023

The water sanitation and hygiene (WASH) sector has provided beneficiaries in low and middle-income countries with latrines and clean water for decades. However, we still need good evidence documenting the expected health impact. This paper investigates why we lack this evidence and ways to move forward. Using mTEC agar, we monitored E. coli contamination on selected “hotspot” surfaces within the kitchen environments of 32 low-income households in Dhaka, Bangladesh, every six weeks for two years. Despite being washed, the highest average contamination was found on food plates, at 253 cfu/10 cm2, followed by cutting knives, with 240 cfu/10 cm2. The drinking vessel surfaces and the latrine doorknobs had the lowest contaminations, with E. coli means of 167 and 73 cfu/10 cm2, respectively. These findings imply a need to measure an individual’s pathogen exposure as close to the mouth as possible to estimate the true pathogen exposure. The paper proposes introducing the new “personal domain”—the point of consumption—as the physical sphere in which WASH interventions should be assessed. With this approach, we can observe and quantify the different pathogen exposure routes and, with this, further improve WASH interventions.
The Prevalence of Immediate Hypersensitivity Reactions to the BNT162b2 mRNA Vaccine against SARS-CoV-2: Data from the Vaccination Campaign in a Large Academic Hospital
Authors: Paoletti Giovanni , Pepys Jack , Bragato Maria , Paoletti Sandro , Piona Alessandra , Messina Maria , Racca Francesca , Ferri Sebastian , Nappi Emanuele , Costanzo Giovanni , Del Moro Lorenzo , Puggioni Francesca , Canonica Giorgio , Azzolini Elena , Heffler Enrico
Published: April 2023

The anti-SARS-CoV-2 vaccination has probably been the most effective tool for preventing the infection and negative outcomes of the COVID-19 disease, and therefore for interrupting the pandemic state. The first licensed SARS-CoV-2 vaccine was BNT162b2, an mRNA vaccine that has been widely used since the earliest stages of the global vaccination campaign. Since the beginning of the vaccination campaign, some cases of suspected allergic reactions to BNT162b2 have been described. Epidemiological data, however, have provided reassuring results of an extremely low prevalence of these hypersensitivity reactions to anti-SARS-CoV-2 vaccines. In this article, we describe the results of a survey carried out through the use of a questionnaire, administered to all the health personnel of our university hospital after the first two doses of the BNT162b2 vaccine, which investigated the development of adverse reactions after a vaccination. We analyzed the responses of 3112 subjects subjected to the first dose of the vaccine; among these, 1.8% developed symptoms compatible with allergic reactions and 0.9% with clinical manifestations of possible anaphylaxis. Only 10.3% of the subjects who had allergic reactions after the first injection experienced similar reactions after the second dose and none of them experienced anaphylaxis. In conclusion, the anti-SARS-CoV-2 vaccination is rarely associated with severe allergic reactions and the second dose of vaccine is safe for this group of patients.
Narratological approach of the film adaptation of Thérèse Desqueyroux by François Mauriac
Authors: Gialatzi Despina
Published: April 2023

The aim of this paper is to examine translation as a phenomenon from literature into movies through isotopies. In particular, the research concen-trates on the intertextual phenomenon between the original classic version in literature and the two film versions (1962 and 2012). In Gideon Toury’s work, translation is seen as an intertextual phenomenon. The three “texts” form  an  intertextual  triangle.  Mauriac’s  classic  novel  is  at  the  top  of  the  triangle as a significant guide, and at the same time the two films rest on the triangle’s base. In 1927, the French writer, François Mauriac wrote his iconic  work,  Thérèse  Desqueyroux.  In  his  novel,  the  writer  describes  the  tragic  story  of  a  poisoner.  This  is  a  woman  who  hovers  between  the  romantic of the past and the realism of the present. The young heroine lets herself  go  psychically  into  her  dreams,  and  she  does  not  see  reality  in  its  logical dimension. Her marriage is not a romantic, happy and ideal union taken  from  the  romantic  works  of  the  19th  century.  It  is  a  cold,  cruel  and  indifferent marriage. In a way, Thérèse is a victim of herself. Unveiling the psychographic image of this fatal woman called Thérèse D, the application of Greimas’s narratological method offers a fertile field of research, and the examination of the transformation into a double cinematographic portrait. Thérèse  is  a  woman  prisoner  in  her  name:  Desqueyroux.  The  narrative  structure of the work turns on the fragile psyche of the heroine. Is she real-ly a fragile female figure or, a cruel poisoner in a search of mental freedom?
Methodology for content analysis of the digital medicine information space
Authors:   Federal State Budgetary Institution “Russian State Research Center – Burnasyan Federal Medical Biophysical Center” of the FMBA of Russia, Moscow, Berdutin V. A. , Romanova T. E. ,   FSBEI HE Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod
Published: April 2023

In the near future, global healthcare will undergo fundamental changes associated with digital transformation of medicine, which is supported by numerous innovative technologies. Digitalization of domestic healthcare is currently a priority for its development. It requires medical professionals to have specialized knowledge and a willingness to make the most of the advances in digital medicine. Content analysis of the information space of digital medicine makes it possible to determine people's attitudes by learning the opinions of representatives of various strata of civil society, expressed in the media, and to draw a conclusion about the state of healthcare both in Russia and around the world. In this regard, the methodological support of computer-based content analysis, which must be carried out at the most modern technological level, is of particular interest. It is no coincidence that the purpose of this article is to consider key issues related to the use of innovative approaches and algorithms for assessing the information space of digital medicine.
High technologies in medicine and neurology at the current stage: problems and prospects
Authors:   FSBI DPO ", Pomnikov V. G. ,   St. Petersburg Institute of Advanced Medical Experts",   of the Ministry of Labor of Russia, Alekhin A. A. ,   FSBI DPO "St. Petersburg Institute of Advanced Medical Experts" of the Ministry of Labor of Russia, Sakovskiy I. V. ,   FSBI DPO "St. Petersburg Institute of Advanced Medical Experts" of the Ministry of Labor of Russia, Belozertseva I. I. ,   FSBI DPO "St. Petersburg Institute of Advanced Medical Experts" of the Ministry of Labor of Russia, Dudkina O. V. ,   FSBI DPO "St. Petersburg Institute of Advanced Medical Experts" of the Ministry of Labor of Russia, Amelina V. V. ,   FSBI DPO "St. Petersburg Institute of Advanced Medical Experts" of the Ministry of Labor of Russia
Published: April 2023

The article presents the data on the most important technological solutions that have been implemented in medicine and neurology over the past five years. The analysis of innovations is carried out, their role in the development of medical science is shown, their strengths and weaknesses are highlighted, and problems and prospects for further development of high technologies are reflected.
Individual labor relations: theoretical and legal aspect
Authors:   JSC ", Kuznetsov A.M. ,   Problematical Assets Fund",   , Moscow
Published: April 2023

The article is devoted to an actual and significant topic today concerning individual labor relations. This is justified by the fact that individual labor relations regulate mutual interests agreed between the parties to the employment contract. This article analyzes the essence of individual labor relations and their place in the field of labor law along with relations directly related to labor. Their structure is considered, the elements are analyzed. The distinctive features of individual labor relations are formulated taking into account modern reality. The author’s definition of the category under study is presented.
VARIASI KETEBALAN MEDIA BIO CERAMIC BALL FILTER UNTUK MENURUNKAN TOTAL COLIFORM PADA AIR MINUM
Authors: Wahyudiniar Devira Nuradzila , Pujiono Pujiono
Published: April 2023

Air minum sebagai salah satu kebutuhan penting untuk manusia, sehingga harus sesuai dengan regulasi yang ditetapkan. Air minum yang ada di Kantin PT. X melakukan pengolahan hanya dengan memasak air hingga mendidih, hasil pemeriksaan kualitas bakteriologis tidak memenuhi syarat untuk parameter Coliform sebesar 119 APM/100 ml menurut Peraturan Menteri Kesehatan RI No. 492 Tahun 2010 tentang Persyaratan Kualitas Air Minum. Sumber air berasal dari sumur bor, jarak sumur bor < 10 meter sumber pencemar. Perlu adanya pengolahan tambahan dengan metode filtrasi menggunakan filter Bio Ceramic Ball untuk menurunkan nilai total Bakteri Coliform. Tujuan penelitian ini untuk mengetahui efektivitas variasi ketebalan filter Bio Ceramic Ball terhadap penurunan total Coliform, dengan variasi ketebalan 25 cm, 30 cm, dan 35 cm. Jenis penelitian ini yaitu penelitian eksperimen dengan desain pretest postest whitout control. Besar sampel sebanyak 36 sampel dengan kebutuhan air minum untuk pemeriksaan sebanyak 3,6 liter. uji yang dilakukan menggunakan uji one way anova karena data penelitian berdistribusi normal. Rata-rata penurunan nilai total Coliform pada variasi ketebalan 25 cm sebesar 104 APM/100 ml, variasi ketebalan 30 cm sebesar 112 APM/100 ml dan variasi ketebalan 35 cm sebesar 116 APM/100 ml. Ini menunjukkan hasil penelitian  yang paling efektif  penurunan total Bakteri Coliform adalah ketebalan filter Bio Ceramic Ball 35 cm yang mencapai 99,02%. Ketebalan dapat ditingkatkan sehingga hasilnya lebih baik.
Cahiliye Dönemi Kâhinelerinden Zerkâ-i Yemâme ve Darîr’in "Siyer-i Nebî"sindeki Yansımaları
Authors: DİKMEN Melek
Published: April 2023

İslamiyet etkisinde gelişen Türk edebiyatında tarihî ve efsanevî şahsiyetlerin zikredilmesi, hatta bazı özellikleri ile sembol olarak kullanımı dikkat çekmektedir. Bu anlamda, görme kuvveti ve ferasetiyle anılan, Cahiliye dönemi Arap toplumunda meşhur olan kâhine Zerkâ-i Yemâme’den bahsetmek mümkündür. Zerkâ-i Yemâme’nin üç günlük mesafeden gelenleri görebilecek kadar keskin bir görme gücüne sahip oluşu Klâsik dönem şiirlerinde remiz olarak kullanıldığı gibi siyer türündeki eserlerde de zikredilmiştir. Türk edebiyatındaki siyerlere öncülük eden Darîr’in Siyer-i Nebî’sinde de söz konusu kadın karakter farklı yönleriyle anlatılmış ve hatta Topkapı Sarayı Müzesi Kütüphanesi H. 1221 nolu minyatürlü nüshasında olaylar tasvirlerle görsel hâle getirilmiştir. Eserde Zerkâ, Hz. Peygamber’in babası Abdullah ile evlenmek istemesi, basireti, kabilesine baskın yapan Gassânlılara karşı uyarmasına rağmen söylediklerinin dikkate alınmaması ve Hz. Peygamber’in dünyayı teşrifine engel olmak için annesi Âmine’yi öldürtmek istemesi yönüyle söz konusu edilmiştir. Metni görsel hâle getiren resimler, hem olayların geçtiği hem de eserin resmedildiği dönemin zihniyetini ve inanışlarını ortaya koyması yönüyle mühimdir. Çalışmada Zerkâ hakkında bilgi verildikten sonra Darîr’in eserinde anlatılan olaylar ve tasvirleri hakkında değerlendirmeler yapılmıştır.
Educação diferenciada para o pouso da Cajaíba: uma proposta de trabalho para o outro lado da linha?
Authors: E Cruz Marina Alves Novaes , Teixeira Jacqueline , De Sá Maria Inês Rocha
Published: April 2023

Este artigo aborda as ações desenvolvidas pelo Núcleo de Extensão e Pesquisa em Educação Diferenciada –­ Nepedif e pelo Observatório de Territórios Sustentáveis e Saudáveis da Bocaina – OTSS junto à comunidade tradicional caiçara[1] do Pouso da Cajaíba, Paraty/RJ, Brasil, pretendendo discutir questões relativas às práticas pedagógicas diferenciadas como forma de preservação dos saberes populares caiçaras. Assim, dialogando com Boaventura de Souza Santos e Miguel Arroyo, o texto apresenta os caminhos tomados para discutir a Educação Diferenciada: começando pelo seu conceito e pela definição atual de comunidade tradicional e chegando à criação do Nepedif e às ações desenvolvidas pelo grupo.
Avaliação do conhecimento sobre testagem, vacinação e transmissão do vírus do papiloma humano (HPV) de profissionais e estudantes da saúde na Unidade Básica de Saúde número 1 da Estrutural/DF
Authors: Aguiar Rafael Cavendish , Menezes João Paulo Sousa , Melo Ana Estrela , Santos Mateus Américo Galvão , Vitorino Thiago Callak Teixeira , De Carvalho Clerio Augusto Ferreira Arosteguy , Stivanin Geovanni Félix , De Lima Sergio Henrique Mattioda
Published: April 2023

A infecção pelo HPV é altamente prevalente mundialmente e no Brasil1,2,5, tendo a maioria dos homens e mulheres sexualmente ativos contraído o vírus durante a vida3. No Brasil, é alta a prevalência entre jovens, inclusive por tipos de alto risco oncológico5,6. Objetivos: O presente estudo tem como objetivo primário avaliar o conhecimento sobre HPV, no que diz respeito ao rastreio, vacinação e transmissão, de profissionais da saúde e de estudantes de medicina e enfermagem lotados na UBS da Cidade Estrutural/DF. Metodologia: Trata-se de estudo transversal, em que foram avaliados 42 estudantes de Medicina e Enfermagem de uma faculdade pública do Distrito Federal, com atividades práticas regulares em uma UBS em região vulnerável em 2020, e 32 profissionais da área da saúde - médicos, enfermeiros, técnicos de enfermagem e agentes comunitários de saúde. Foi aplicado questionário de instrumento de avaliação sobre o conhecimento do HPV adaptado para a língua portuguesa. Resultados: A maioria dos entrevistados (95,9%) obteve pontuação maior ou igual a 70% de acertos no questionário. Identificou-se que estar cursando as séries iniciais de graduações da área da saúde associa-se estatisticamente a menores médias no questionário, em comparação a outros grupos. Foi observado que os profissionais avaliados tiveram pontuações mais baixas em relação à testagem do HPV. Ademais, verificou-se que os estudantes avaliados possuem déficits significativos no que se refere à vacinação contra o HPV, apesar de obterem pontuação geral no questionário acima de 70%. Agentes comunitários de saúde obtiveram médias menores que outros profissionais, apesar de tal constatação não possuir significância estatística. Não foram identificadas médias significativamente diferentes comparando-se entrevistados com ou sem capacitação prévia sobre o HPV. Conclusões: O conhecimento sobre HPV de profissionais e estudantes da área da saúde lotados na UBS avaliada é suficiente, embora existam lacunas. A capacitação de estudantes da área da saúde é importante para o contexto do SUS, por corroborar uma boa formação profissional em saúde, o que gera, irrefutavelmente, ganhos para a sociedade.
The principle of control by diagnosis as a result of the systematic application of fundamental control principles
Authors: Kulik Anatoly
Published: April 2023

The subject of study is the principle of control by diagnosis. The goal is to form a control principle based on a diagnosis as a result of the systematic application of fundamental management principles. Task: an excursion into history of mastering the principles of control. Analysis of features, positive and negative qualities of principles of control by setting influence, by disturbing influence and by deviation. Description of the principle of control by diagnosis. Presentation of diagnostic functional models of diagnostic objects. Giving an example of the application of the principle of control by diagnosis. The methods used are: retrospective analysis, the method of constructing graphic functional schemes, the method of the space of discrete states, the method of forming diagnostic functional models, methods of bench research and simulation modeling. The following results were obtained: the process of mastering control principles was decomposed into three stages: intuitive understanding of principles, mastering them in industry and scientific mastering. Features of the principles of control by setting influence, disturbing influence and by deviation are described. The principle of control by diagnosis and the functional scheme of a rational control system are proposed. Diagnostic functional models are presented that reflect the relationship between direct signs of destabilizing influences and indirect signs that are directly available for measurement. The results of experimental studies are presented, which testify to the possibility of rational control of the operability of sensors of flight parameters, in particular, of angular movements, during the action of various types of destabilizing influences. Conclusions. The scientific novelty consists in the formation of a new principle of control based on diagnosis and the development of a number of tools, the use of which allows to ensure the functionality of automatic control objects under the conditions of various types of destabilizing influences.