bluuebunny/crossref_metadata_2025 huggingface dataset:
Den Körper neu erschaffen – Der Wunsch nach Überwindung der Geschlechtsinkongruenz
Authors: Teyrowsky Angela
Published: October 2024

In den letzten Jahrzehnten der Forschung hat sich nicht nur unser Verständnis von dem Phänomen Trans* im Hinblick auf biologisch determinierte wie auch psychoanalytische Theorien erweitert, sondern auch unser Wording dementsprechend angepasst. Den Terminus Transvestitismus wechselte im Laufe der Zeit die Bezeichnung Transsexualität ab, später sprach man dann von der Transidentität, von Transgender, und schließlich gelangte man in internationalen Klassifikationssystemen dann zum Begriff der Geschlechtsinkongruenz, während hingegen die Geschlechtsdysphorie das Leiden an dem Inkongruenzempfinden widergeben soll. Damit einhergehend finden sich in der Fachliteratur im Zuge von mittlerweile 70 Jahren sehr kontroversielle Ansichten, auch innerhalb der Psychoanalyse. Es bleibt zu vermuten, dass sich in dieser Begebenheit wohl der Spannungsgrad dieses Phänomens abbildet, nicht nur in Form eines Inkongruenzempfindens im Inneren der Betroffenen, sondern auch in Form von zum Teil sehr polarisierenden Diskursen in der Fachwelt und sogar innerhalb der einzelnen Disziplinen. Neben dem state-of-the-art in der Transgendergesundheit stellt es vor allem in psychodynamisch orientierten Psychotherapien oftmals eine Herausforderung dar, im Wissen um die frühe Entwicklung des Menschen und unter Berücksichtigung von ethischen Gesichtspunkten, Menschen in ihrem Transitionsprozess zu begleiten und im Falle von Indikationsstellungen dann in Form von Stellungnahmen auch zu verschriftlichen.
Der Körper als Ort der Schmerzen – Die »Performing Art« Marina Abramovićs und Robert Wilsons als Arbeit an der Erinnerung des Körpers
Authors: Engelhardt Stephan
Published: October 2024

Marina Abramović fügt sich Schmerzen zu. Sie schneidet sich, peitscht sich aus, kämmt sich, bis sie blutet und wir als Publikum schauen zu. Diese körperlichen Torturen sind echt und finden als Performance in einer Galerie statt. Marina Abramović ist die Darstellerin, und wir das Publikum. Dieses symbolische Geschehen folgt einer sozialen Übereinkunft und kann nicht mit der alltäglichen Wirklichkeit verwechselt werden. Was machen diese beobachteten schmerzhaften körperlichen Vorgänge mit uns? In der primären mimetischen Resonanz fühlen wir für einen Moment den Schmerz so, als wenn er unser eigener wäre. Die Sprache des Körpers wird durch ein physisches Nachempfinden dechiffriert. Der Körper ist der Ort, die mimisch-gestischen Ausdrucksmöglichkeiten seine Sprache. Die Schmerzen als Mitteilungen werden ohne Worte verstanden. Auf der körperlichen Ebene ermöglicht die mimetische Resonanz eine unmittelbare Interaktion. Alle Beteiligten sind für einen Moment miteinander verbunden und teilen ein gemeinsames Gefühl. Die schmerzhaften körperlichen Vorgänge der Marina Abramović lösen als Foto oder Film bei uns eine vergleichbare Reaktion aus. Wir reagieren in der sekundären mimetischen Resonanz so, als wenn das Abbild des selbstverletzenden Spiels eine konkrete physische Realität wäre.
Robert Wilson erzählt in der Oper »The Life and Death of Marina Abramović« die Biografie der Künstlerin. Aus der traumatisierenden Kindheit, der künstlerischen Arbeit mit ihrem Körper macht er ein Theaterstück. Die physischen Vorgänge werden nicht direkt wiedergeben, sondern in ein abstraktes Zeichensystem aus Licht, Bewegung, Worten und Musik überführt. Die schmerzhaften Gefühle werden in die Sprache der theatralen Bühnenillusion übersetzt. Als betrachtende Person ergänzen wir das Gesehene, imaginieren das Dargestellte weiter und folgen der Erzählung der Schmerzen, als wäre es ein Traum und das von uns Weiterimaginierte konkret. In dieser imaginativen tertiären mimetischen Resonanz erleben alle gemeinsam auf eine mittelbare Weise einen Moment einer intensiven Gegenwart. Diese drei unterschiedlichen Formen der mimetischen Resonanz finden im therapeutischen Prozess zufällig statt oder werden in der Methode der szenischen Imagination mit Absicht herbeigeführt.In einer medial geprägten Wirklichkeit, in der die Zeichen auf keine konkreten Erfahrungen mehr verweisen und so bedeutungslos werden, schafft diese unmittelbare physische Erfahrung und das Wiedererleben einer physischen Erfahrung, die einmal tatsächlich gesammelt wurde, eine verlässliche Wirklichkeit im Hier und Jetzt. So wird der Körper zum Ort, um etwas neues denken zu können.
Wenn das Patriarchat durch und über den weiblichen Körper spricht – Über Lustquellen und Leidenswege des weiblichen Geschlechts
Authors: Ebermann Traude
Published: October 2024

Mein Beitrag handelt von der Thematisierung des Körper-Seele-Zusammenhanges bei Frauen* in Psychoanalyse, Medizin und Gesellschaft.
Dazu folgt ein historischer Exkurs, wie das Wissen über das weibliche Geschlecht als leibhaftige Erfahrung von Frauen* im Laufe von Jahrhunderten in der von Männern definierten akademischen Medizin verdrängt wurde. Die Frauen*Gesundheitsforschung zeigt den patriarchalen Verdrängungsprozess auf.
Das Recht der Frau* auf Selbstbestimmung über ihren Geschlechtskörper und ihre Sexualität wird anhand der Fristenlösung angeführt.
Die Verfügung über die Reproduktion kommt damit erneut ins Zentrum der Wertschätzung, und damit auch die Vulva. Mit einer Fallvignette mit dem Muschel-Motiv schließe ich meine Ausführungen.
Causative factors of Abandoned Urban Housing Projects and Strategies for Revitalization in Ibadan, Nigeria
Authors: Obakin Olufunmilola Adetayo , Afolami Samuel Kehinde , Akande Oluwafemi Kehinde
Published: October 2024

In Nigeria, over 56,000 projects have been abandoned, leading to negative societal and urban impacts, including wasted investment, job losses, increased crime rates, visual pollution, and disruption of urban planning. These abandoned projects, which include residential, commercial, and industrial buildings, have significant multiplier effects on the construction industry. As the housing sector plays a vital role in a country's economy, the issue of abandoned urban housing projects, particularly in Ibadan, Nigeria’s third-largest city, poses serious challenges. These challenges affect the city’s economic growth, social cohesion, and environmental quality, yet there is limited research addressing the problem. This paper investigated the causes of abandoned housing projects in Ibadan, aiming to find ways to revive them and prevent future abandonment. A structured questionnaire (n=45) was administered to consultants and professionals in the built environment (architects, engineers, quantity surveyors, and builders). Key causes of abandonment were identified, along with impacts such as building dilapidation, environmental decline, and urban visual displeasure. The paper recommended the establishment of regulatory frameworks for periodic inspections of ongoing projects and requiring developers to have exit strategies for financial setbacks. It also emphasized policies that promote repurposing abandoned buildings for public services, such as affordable housing or community centers. The conclusion stressed that without addressing the root causes, urban aesthetics and adequate housing provision will continue to suffer.
SISTEM INFORMASI AKUNTANSI PROSES BISNIS JOB ORDER PADA PERUSAHAAN JASA
Authors: Purwatiningsih Esty , Sumarna Alfonsa Dian
Published: October 2024

Accounting information systems are very important for newly established micro start-ups. Especially operational standards for main business processes. This can help start-ups carry out their business processes in a structured, orderly, controlled, and standardized manner. This applied research discusses the preparation of job order procedures that can be applied to a micro start-up business in production house services. This research aims to create accounting information systems and organize a simple job order transaction workflow with robust internal control. Procedures are prepared narratively and in flowchart form for each job order type transaction that occurs by applying the principles of effective and efficient internal control. This research method is descriptive qualitative. It can be concluded that micro start-up businesses need to have job order procedures in the form of written narratives or the form of flowcharts and also bookkeeping, which contain elements of an internal control system to adapt to the limited resources available in this micro start-up business. Keywords: Accounting Information System, Job Order, Business Process
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI UNDERPRICING SAHAM PADA PENAWARAN UMUM PERDANA
Authors: Rahma Anneu Cania , Wiharno Herma , Nurhandika Arief
Published: October 2024

This study aims to examine and analyze what factors influence stock underpricing in companies that carry out Initial Public Offerings. The research method used in this research is descriptive method and verification method. The population in this study are all companies that are conducting Initial Public Offerings in 2019-2021. The samples obtained using quota sampling are 145 companies. The analysis technique used is multiple linear regression. Data processing uses the IBM SPSS 20 program The results of this study indicate that profitability, market value, liquidity, and firm age has a negative and significant effect on stock underpricing. Capital structure has a positive and significant effect on stock underpricing. All variables in this study have significant influence on stock underpricing. Then the regression estimation results show that the predictive ability of the 5 independent variables on stock underpricing is 73%, while the remaining 27% is influenced by other factors outside the model which are not included in this analysis. Keywords: Profitability, Market Value, Capital Structure, Liquidity, Firm Age, Underpricing.
PENGARUH PENGALAMAN AUDITOR, SKEPTISME, INTUISI, RISIKO AUDIT DAN KEAHLIAN FORENSIK TERHADAP PENDETEKSIAN KECURANGAN (FRAUD)
Authors: Juliyanti Kania , Muslim Ade Imam
Published: October 2024

This research aims to determine the influence of auditor experience, skepticism, intuition, audit risk, and forensic expertise on fraud detection at Public Accounting Firms in Bandung City. This research is a type of quantitative research. The sampling technique was carried out using purposive sampling technique. So the samples obtained were 11 public accounting offices in Bandung City. The data collection technique used was a questionnaire distribution. The data analysis technique used in this research is multiple linear regression analysis with the SPSS 24 software tool. The results of this research show that auditor experience, skepticism, audit risk and forensic expertise influence fraud detection while intuition has no influence on fraud detection. and simultaneously the auditor's experience, skepticism, intuition, audit risk, and forensic expertise influence fraud detection.Keywords: auditor's experience, skepticism, intuition, audit risk, forensic expertise, and fraud detection.
FAKTOR YANG MEMPENGARUHI PEMILIHAN KARIR AUDITOR PADA MAHASISWA STIE SURAKARTA
Authors: Anggraini Caecilia Dian , Kholis Nur
Published: October 2024

The purpose of this study is to identify the variables that influence the decision of STIE Surakarta students to work as auditors. The main data was collected through a survey distributed to accounting students in semester 7 of STIE Surakarta. A sample of 44 respondents was obtained by accidental sampling. The data were analyzed by multiple linear regression. The research findings show that professional training, professional recognition, and labor market considerations have a positive and significant effect on the career choice of auditors of STIE Surakarta students. However, the gender variable has no significant effect and has a negative effect on the auditor's career choice. Overall, professional training, professional recognition, labor market considerations, and gender all affect auditor career choice. Keywords: Professional Training, Professional Recognition, Labor Market Considerations, Gender, Career Selection.
PENGARUH LIABILITAS JANGKA PANJANG DAN OPERASIONAL COST TERHADAP NET PROFIT PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI
Authors: Kamaludin Nurhadi , Ristiyana Wiwit
Published: October 2024

The purpose of this research is to understand the influence of long-term liabilities and operational costs on net profit in manufacturing companies listed on the Indonesian Stock Exchange (BEI) from 2017 to 2021. This research is a quantitative descriptive study, which involves numerical data. The sample size for this study consists of 11 companies out of a total population of 17, resulting in a total of 55 financial reports as samples. In practice, this research uses SPSS 21 software, and the data analysis technique employed is multiple linear regression analysis. The t-test results show that long-term liabilities significantly affect net profit with a significance level of 0.041. Similarly, operational costs significantly impact net profit with a significance level of 0.000. The results of the F-test indicate that long-term liabilities and operational costs collectively influence net profit significantly at a significance level of 0.000. The coefficient of determination test results show that 91% of the variability in net profit can be explained by long-term liabilities and operational costs, while the remaining 9% is explained by other variables.
Characterizing Performance Tradeoffs from Air Traffic Management Services for Advanced Air Mobility
Authors: Murça Mayara Condé Rocha , Souza Wallace Silva Sant’Anna , Ribeiro João Vitor Turchetti
Published: October 2024

The emergence of Advanced Air Mobility (AAM) has called for novel Air Traffic Management (ATM) solutions to enable the projected high number of operations, particularly in already dense and complex metroplex airspace. Understanding the multidimensional performance impacts of developing air traffic rules, procedures, and services is key to guiding this new traffic management system design. This paper presents a simulation framework to provide a quantitative assessment of the operational performance of ATM services in support of AAM. The framework embeds several modules for high-fidelity modeling of urban air traffic flows based on actual data, ATM service provision, stochastic simulation, and performance quantification. Two key services are analyzed: airspace geofencing and strategic deconfliction. We evaluate the use of these services in a scenario of air mobility operations associated with daily urban commuting in the Sao Paulo metropolitan region. Monte Carlo experiments are performed to simulate the execution of aircraft trajectories managed under different ATM service configurations, allowing for the characterization of operational performance tradeoffs, particularly in terms of safety and efficiency. The work contributes to quantifying the value of novel ATM services for integrating AAM operations in dense metroplex airspace, supporting their design and implementation.
Vibration Control for Laminated Composite Spherical-Cylindrical-Combined Shells: Theory and Experiment
Authors: Zang Jian , Zhang Rong-Yao , Yang Yang , Zhang Zhen , Song Xu-Yuan , Zhang Ye-Wei , Chen Li-Qun
Published: October 2024

Considering the structural damage and instability due to extensive vibrations, the present investigation focuses on the dynamic characteristics analysis and vibration control for aerospace structures such as rocket stages and aircraft cowling, modeled as laminated composite spherical-cylindrical-combined shells (SCCSs). The theoretical model of the SCCSs is established by a series of artificial connection and boundary springs. The proposed method’s validity is confirmed through finite element analysis and experimental validation. Nickel-titanium-steel wire ropes (NiTi-STs) are then introduced as a passive vibration control method for the SCCSs. Both circumferential and axial NiTi-ST laying schemes demonstrate good vibration control capabilities on the SCCSs. For similar lengths of NiTi-STs, the vibration control effect of circumferential laying schemes is superior to that of the axial one. Furthermore, the vibration control effect of the circumferential schemes is found to be dependent on the number and positioning of NiTi-STs. The influence of the NiTi-ST structural parameters on the vibration control performance is also analyzed; adjusting the structural parameters appropriately is helpful to improve the vibration reduction effect.
Управління змінами: порівняння східних та західних теорій менеджменту
Authors:   Національний університет «Чернігівська політехніка», Повна Світлана , Шабардін Дмитро ,   Національний університет «Чернігівська політехніка»
Published: October 2024

У статті зроблено порівняння західних та східних теорій управління змінами. Визначено, що при розгляді західних теорій управління змінами основна увага приділяється страху впровадження змін та подоланню опору змінам. Східні теорії менеджменту орієнтовані на постійне запровадження невеликих удосконалень, що стає повсякденною діяльністю. При порівнянні принципів управління змінами у західних та східних теоріях менеджменту виявлено, що східні теорії управління багато уваги приділяють самоменеджменту та вдосконаленню людей та запевняють, що робота з управління змінами має викликати захоплення та ентузіазм. Також у командну роботу щодо розробки та впровадження удосконалень залучаються абсолютно всі без винятку, увага направляється на гарні відносини в колективі.
Інвестиційна інфраструктура як ключовий фактор інноваційного розвитку високотехнологічних галузей України
Authors:   Національний університет «Чернігівська політехніка», Шпомер Тетяна , Суховерський Михайло ,   Національний університет «Чернігівська політехніка», Кіронда Ігор ,   Національний університет «Чернігівська політехніка»
Published: October 2024

У статті досліджено сутність та роль інвестиційної інфраструктури в інноваційному розвитку високотехнологічних галузей України. Виявлено й охарактеризовано основні фактори зовнішнього і внутрішнього середовища, які визначають ефективність функціонування та розвитку інвестиційної інфраструктури. До ключових факторів, які визначають результативність розвитку інвестиційної інфраструктури віднесено: інституційне середовище, інвестиційний клімат, рівень капіталізації фінансових ринків, рівень розвитку банківської системи, рівень розвитку венчурного інвестування, а також наявність державної підтримки інвестиційних процесів. Охарактеризовано взаємозв'язок і взаємозалежність між факторами розвитку інвестиційної інфраструктури та сформульованої їхній вплив на розвиток високотехнологічних галузей.
Formulation, Development & Evaluation of Mallotus philippensis Extract Loaded NLCS based Nanogel for Psoriasi.
Authors: . Nandini . , Yadav Hemant KS , . Jasmine . , Punian Sanchit .
Published: October 2024

The current study’s objective was to develop and evaluate the potential of Bergenin-loaded nanostructured lipid carriers (NLCs) as a novel topical therapeutic for psoriasis, obtained from Mallotus philippensis. NLCs loaded with Bergenin were created using a modified Hot-melt emulsification technique, and then Box-Behnken design optimization was performed. The Independent factors were concentration of solid lipid, the concentration of liquid lipid and the concentration of surfactant. Particle size, entrapment efficiency, and drug permeation percentage were the dependent variables. The Bergenin-nano-lipid carriers (NLCs) that has been optimized has a Particle size of 148 ± 0.37 nm, an %Entrapment efficiency of 93.44 ± 0.45%, and a drug permeation percentage was found to be 83.56 ± 0.137. and the zeta potential was - 0.0617 ± 5.53 mV and the polydispersity index (PDI) was 0.30 ± 0.03. Bergenin’s existence within the NLCs was verified by FTIR. The outcomes show that Nanostructured lipid carriers have the ability to deliver Bergenin for topical psoriasis treatment.
Formulation Development and Evaluation of Transdermal Patches of Apigenin.
Authors: Tirkey Fatima . , Dwivedi Abhishek .
Published: October 2024

Apigenin is a flavonoid that is abundantly present in fruits and vegetables. It has a diverse range of therapeutic properties, including cardioprotective, neuroprotective, analgesic, and cancer-preventive effects. Its safety profile, even at higher doses, makes the compound particularly valuable. Apigenin, along with excipients, was used to formulate patches using the solventcasting method on a glass mold. Seven distinct batches of patches were formulated using different combinations of polymers. The drug-polymer ratios employed in these formulations were (1:2), (1:3), (1:4), (1:4), (1:(2:8), (1:(1:9), and (1:(2:8) for both drugs. The formulated patches were evaluated and results indicate that the transdermal patches (TP5) have promising results.
Characterization of Bimetallic (Zinc and Gold) Nanoparticles of Cryptostegia grandiflora Plant Extract and Their Biological Screening .
Authors: Jadhav RS . , Inamdar AT . , Mohite SK . , Gavali RM .
Published: October 2024

The goal of this learning was to explore the uses of Cryptostegia grandiflora plant extract in the green formulation of bimetallic zinc-gold nanoparticles along with pharmacological evaluation. Green synthesis and other techniques are more advantageous than chemical and physical procedures because they produce nanoparticles in an environmentally responsible and economically viable manner. An ethanolic extract of C. grandiflora was obtained through the use of Soxhlet extraction. Additionally, an ethanolic extract of C. grandiflora and components from the extract were identified using GC-MS research after mixing plant extract (C. grandiflora) with zinc acetate and chloroauric acid solutions and letting it sit for a while. UV-visible spectroscopy was employed to analyze the formation of nanoparticles, while FTIR was used for their characterization.
Development and Characterization of Gingerol-Assisted Silver Nanoparticle and Chitosan Alginate Membrane for Antibacterial and Wound Healing Activity.
Authors: Khaire Manisha . , Bigoniya Papiya .
Published: October 2024

This study synthesized and characterized gingerol-loaded silver nanoparticles (Ag-NPs), which were incorporated into chitosan-alginate (Cs/Alg) films for advanced wound care applications. Gingerol was isolated with a 9.81% yield, forming pale-yellow needle-shaped crystals with a melting point of 32ºC. The purity and structure of gingerol were confirmed through thin-layer chromatography (TLC), UV-visible, fourier-transform infrared spectroscopy (FTIR), and high-performance liquid chromatography (HPLC) analyses. The synthesized Ag-NPs, particularly from the GN3 batch, exhibited a small particle size (36.52 ± 3.52 nm), high stability (zeta potential of -23.20 mV), and notable encapsulation efficiency (76.35%) and yield (74.11%). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses revealed their spherical and smooth morphology. Stability tests over three months showed no substantial changes in particle size, ZP, or %EE. The Cs/Alg films demonstrated appropriate thickness, weight, water uptake, and pH changes, with GN-CM4 showing the best performance. In-vitro drug release studies indicated increased release rates, especially for GN-CM4, which also exhibited the highest antibacterial activity. In-vivo studies on excision and burn wound models showed that GN-CM4 promoted complete wound closure by day 21, enhanced hydroxyproline levels, reduced myeloperoxidase content, and facilitated superior tissue regeneration. These findings underscore the potential of gingerol-loaded Ag-NPs in enhancing wound healing through their anti-inflammatory and antibacterial properties.
Design and Development of Solid Lipid Nanoparticles of Tofacitinib Citrate for the Treatment of Rheumatoid Arthritis: A Quality by Design Approach.
Authors: Deepika V . , Naik S Srinu
Published: October 2024

Solid lipid nanoparticles, or SLNs, have gained popularity recently as a possible drug delivery method. However, the idea of using SLNs for organ and site-specific drug administration is still in its early stages due to the difficulties associated with this approach. The aim of this study is to develop SLNs with improved pharmaceutical characterization and anti-arthritic efficacy. Tofacitinib citrate (TC)-loaded SLNs were created using the microemulsification method, with the addition of stearic acid, chitosan, and Tween 80 to improve skin permeability. Seventeen SLNs were developed and characterized for particle size, entrapment efficiency (EE), and percentage drug release according to the Box-Behnken design. The DSC analysis revealed a strong endothermic peak at 166.18°C, significantly different from the pure TC reported at 218.05°C. This indicates a notable alteration in the endothermic peak of the SLNs, demonstrating a relationship with the excipients used in this investigation. XRD study highlighted significant characteristic drug peaks at positions 21.06 and 23.63 (2ɵ). These peaks represented the modifications that were seen in pure TC. The SEM analysis of the optimized lipid nanoparticles showed a smooth surface and a spherical appearance. The particle size analysis of the optimized formulation showed an average size of 181.5 nm. Also, the polydispersity index (PI) revealed a value of 0.495, indicating homogeneous dispersion. The zeta value was 8.2 mV, indicating stability.
Bioguided Fractionation and Isolation of Natural Antidiabetic Agents from Polyherbal Tablet.
Authors: Vikhe Sunayana R , Vikhe Sharvari V , Vikhe Rahul L , Ghawate Vilas B , Putera Gusti Muhammad Perdana
Published: October 2024

Polyherbal antidiabetic tablets were formulated, evaluated and compressed by combining the powder extract of Nigella sativa, Trigonella foenum, and Glycyrrhiza Glabra. A number of tests were carried out, including a uniformity weight test, an assessment of the tablets’ hardness and friability, an ash value, moisture content, an extractive value that is soluble in water or alcohol, density (bulk and tapped), repose angle, Carr’s index, disintegration time with preliminary phytochemical screening. The tablet also had ex-vivo antidiabetic performance to enzymes alpha-amylase as well as glucosidase. To ensure the presence of active ingredients, thin-layer chromatography was performed. Column chromatography as performed using silica gel G as a stationary phase. The column of material was created using acetic acid, toluene, and ethyl acetate. As follows: (5.0:4.2:0.8) for 10 ml. The mobile phase of the sample, which contains toluene, ethyl acetate, acetic acid (50:42:8) and fractions, was isolated, collected and sent to IIT Bombay for GCHRMS analysis. In GCHRMS, the chemical constituent was found to be 2 H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, Tetrahydro [2 , 2’] bifuranyl-5-one, 1H-Benzimidazole, 2-(1-methylethyl)-, Bifenthrin, Propionamide, 2,2-diphenyl-N-(2-pyridinyl)-, Dihydromyristicin, 2-Dodecanone, di-p-Tolyl sulfone. The tablets showed promising results for alpha-amylase and alpha-glucosidase inhibition activities.
Physiochemical Analysis, Antioxidant Activity, Antimicrobial Activity and Phenolic Profile of Ipomoea eriocarpa R. Br. Leaves.
Authors: Singh Prashant Kumar , Rawat AKS
Published: October 2024

Many active substances found in plants are essential in the treatment of transmissible and non-transmissible ailments. To enhance their well-being and capabilities, most people around the globe use medicines from plants and herbal origin. The goal of the current study was an assessment of physiochemical properties as well as measuring the effect of various solvents (ethanol, chloroform, and water) on the phenolic profile and on free radical scavenging potential. The standard procedures were used for the preliminary phytochemical, physiochemical and fluorescence analysis. Folin-Ciocalteu and colorimetric methods were used to determine the quantitative phytochemical analysis, respectively. The free radical scavenging potential was determined through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′′-casino-bis (3-ethylbenzothiazoline-6-sulphonic) acid (ABTS) assays. The antimicrobial activity was assessed using the disk diffusion method on a range of bacterial and fungal strains. The finding showed that ethanol was the best solvent for extracting polyphenols. The presence of alkaloids, carbohydrates, flavonoids, glycosides, phenolic compounds, and tannins was observed in the plant. Additionally, fluorescence characteristics and physiochemical parameters provided valuable data that can be used to establish standards for this plant. Results of quantitative phytochemical estimation revealed that the ethanol extract had a higher phenolic content (71.82 mg/g GAE) and flavonoid content (82.7 mg/g QE), while the aqueous extract had the lowest phenolic content (27.05 mg/g GAE) and flavonoid content (18.93 mg/g QE). The I. eriocarpa ethanolic extract had the maximum scavenging potential against DPPH (32.36 µg/mL) and ABTS (55.54 µg/mL). The results of the antimicrobial activity assessment also indicate that the ethanol extract exhibited a greater inhibition zone when tested against both bacterial strains. Results of thecurrent study suggested that the ethanolic extract has significant antioxidant potential and has the capability of being a notable source of organic antioxidants for the formulation of functional foods.
Synthesis, Characterization and Antibacterial Studies of New Crown Ether Prodrugs.
Authors: Al-Lammi Marwan Majeed , M Raheem Jameel , Abbas Layla Jasim
Published: October 2024

New three esters (E1, E2 and E3) from crown ethers and drugs were prepared by Stiglich esterification. These procedures began with the reaction of certain quinolones (levofloxacin, ciprofloxacin, and nalidixic acid) with thionyl chloride to produce a considerably more potent acylating agent. Next, for the production of ester prodrugs, 2-hydroxymethyl-15-crown-5 ether (a lariat crown ether) was esterified using an acid chloride in the presence of pyridine. These molecules were synthesized as carrier-mediated prodrugs in order to solve different pharmacokinetic and pharmacological difficulties, enhance physicochemical features, and augment the antibacterial efficacy of the parent drugs by structural modifications while avoiding bacterial resistance. The compounds` structures were verified by FTIR, UV, H1 & 13C-NMR spectroscopy and certain physiochemical qualities. In a concentration-dependent manner, all of the synthesized prodrugs’ biological studies revealed improved activity against certain bacterial species.
Design, Development and Characterization of a Niosomal Anticancer Drug Delivery System Formulation.
Authors: Palva Rajesh S. , K Yadav Vikas , Suthar Rajnikant M. , Shete Rahul
Published: October 2024

Objective: This study set out to create a niosomal formulation of ceritinib with the goal of delivering the medication specifically to the lungs while reducing side effects. Method: Span 60, cholesterol and DCP were combined with the thin film hydration process to create niosomes. A central composite design was used to optimize the formulation, and the design of experiments was used to assess the impact of various variables on vesicle size and entrapment efficiency. The TEM and in-vitro drug release tests were used to analyse the optimized niosomes. Results: 395.5 nm was the particle size, 75.28% entrapment efficiency, 0.321 polydispersity Index (PDI), and -28.0 mV zeta potential of the optimized niosomes. 68.03% of the medication was released after 48 hours. Conclusion: To address the issues with traditional oral ceritinib distribution, ceritinib-loaded niosomes were created in this study as a potential substitute.
Design, Devlopment and Evaluation of Gastroretentive Floating Microspheres of Glibenclamide: In-vitro In-vivo Studies .
Authors: Samanta Radheshyam . , Tiwari Gaurav . , Gupta Naveen . , Maity Dharmendra Singh Rajput Prasenjit
Published: October 2024

The current research study was designed to characterize the ethyl cellulose act as a carrier mediator used to prepare a floating microsphere of glibenclamide for developed gastroretentive sustain release floating drug delivery. Different microspheres of glibenclamide were formulated by the emulsion solvent evaporation technique of glibenclamide with EC in different ratios by using two solvent systems (ethanol and chloroform). After evaluating the micropolitics properties, %of yield value, drug loading efficiency, entrapment efficiency, diameter and surface morphology of the microsphere by using DLS and SEM, in-vitro drug release in gastric content, in-vitro buoyancy, and in-vivo floatation using animal model, compatibility study by FTIR, DSC and any other analytical study to demonstrate all formulation (especially GM2) was showing excellent results. So this work shows great gastro etentive floating drug delivery system for prolonged periods of time which is very useful in future for further study.
Design and Optimization of Solid Lipid Nanoparticles for Enhanced Therapeutic Activity of Linagliptin.
Authors: Yambadi Swathi . , Bakshi Vasudha .
Published: October 2024

To augment oral bioavailability, linagliptin (LGP) loaded solid lipid nanoparticles (SLNs) have been formed using the solvent evaporation technique of emulsification. Utilizing the Box Behken design (BBD), examining the relation between independent and dependent variables was possible. Particle size (PS), entrapment efficiency (EE), and in-vitro drug release (DR) studies were considered response factors, whereas the various concentrations of lipid carrier, surfactant, and co-surfactant were considered process variables for optimization. The design expert program was used to obtain the optimized batch. At 24 hours, it was discovered that the optimized batch expected responses for PS, %EE, and %DR were 105.83 nm, 81.19, and 96.69%, respectively. The observed PS, %EE, and %DR responses of the optimized batch at 24 hours were determined to be 101.36 nm, 80.56, and 96.31%, respectively. There is no interaction seen in the basic physical mixing of drug and polymer, according to the FTIR spectra of pure drugs, polymers, and drug and polymer mixtures. The optimized formulation’s average size was found to be 138 nm by the particle size analysis. Similarly, a value of 0.255 was found by the polydispersity index (PDI). This suggests that the SLN in the formulation has a homogeneous size dispersion. With a zeta value of -32.8 mV, stability is indicated. Linagliptin was effectively developed as a drug with a 24-hour sustained release. Wistar rats were used in the in-vivo evaluation of linagliptin SLN formulations. The drug bioavailability increased five times (a highly significant fivefold increase) in LGP-loaded SLNs (AUC0-t ≈ 134.5 μg*h/mL) compared to raw LGP (AUC0-t = 27.23 μg*h/mL).
Evaluation of the Antihyperlipidemic Effect of Encapsulated Octacosanol for Lipid-Lowering Effect Against High-Fat Diet-Induced Hyperlipidaemia in Experimental Rats.
Authors: AK Singh . , R Kharb . , GS Chakraborty . , B Kandpal J
Published: October 2024

Background: Elevated blood lipid levels, or hyperlipidemia, are the main risk factors for cardiovascular illnesses and are frequently brought on by high-fat diets. Objectives: In this work, high-fat diet-induced hyperlipidemia in experimental rats is used to examine the antihyperlipidemic efficacy of a test formulation containing 1-octacosanol. Method: A healthy female Wistar rat was utilized for investigation, separated into four groups: normal, disease, standard control, and test group, receiving the 1-octacosanol formulation. Results: Hyperlipidemia was induced in the rats through a high-fat diet over 28 days, followed by a 28-day treatment period. Various parameters, including lipid profile (LDL, TC, TG, VLDL, HDL), body weight and antioxidant properties (MDA, SOD, GSH), were evaluated. The results showed that the 1-octacosanol formulation significantly reduced body weight and improved lipid profiles by decreasing levels of TC, TG, LDL and VLDL while increasing HDL levels. Additionally, the formulation exhibited notable antioxidant properties, contributing to its lipid-lowering effects. Statistical analysis using ANOVA and multiple comparison tests confirmed the significance of these findings, underscoring the therapeutic potential of 1-octacosanol in managing hyperlipidemia and mitigating associated cardiovascular risks. Conclusion: The test formulation of 1-octacosanol demonstrated a significant antihyperlipidemic effect in rats with high-fat diet-induced hyperlipidemia. The treatment effectively reduced serum levels of total cholesterol, triglycerides, LDL and VLDL while increasing HDL cholesterol levels. These marks suggest that 1-octacosanol has the potential as a therapeutic agent for managing hyperlipidemia, a key risk factor for cardiovascular diseases.
Unveiling the Multi-Targeted Mode of Action: Investigating the Antiepileptic Activity of Murraya koengii Extract in PTZ-induced Seizures.
Authors: RD Bawankar . , SS Kawarkhe . , SP Deshmukh . , HA Sawarkar .
Published: October 2024

Recurrent seizures are the hallmark of the neurological condition known as epilepsy. Murraya koenigii (curry leaves) has been traditionally used in medicine for various ailments. This study aimed at the anticonvulsant activity of HAEMK using a petylenetetrazole (PTZ) induced seizure model. Behavioral and biochemical parameters were assessed to determine the effectiveness of the extract in mitigating seizures. Albino mice were orally administered with different doses of the extract prior to PTZ administration. The behavioral parameters, including seizure latency, duration and severity, were monitored and recorded. Additionally, acetylcholine esterase, GSH, and malondialdehyde (MDA), three indicators of oxidative stress, were assessed in brain tissue homogenates. HAEMK-treated groups demonstrated a substantial increase in seizure latency and a decrease in seizure length and intensity compared to the control group. A dose-dependent MDA and acetylcholine esterase decreased concurrent GSH rise were seen in the HA-treated groups. These findings suggest that the hydroalcoholic extract of M. koenigii possesses antiepileptic activity, possibly mediated through its antioxidative mechanisms.
Novel Approaches and Emerging Trends in Hydrotropic Solubilization Technology
Authors: Aime Aliunui . , Bagga Harpritkaur . , Chaudhari Gunjan . , Vyas Ujwal .
Published: October 2024

Hydrotropic solubilization technology enhances the solubility and bioavailability of poorly water-soluble drugs, a major challenge in pharmaceutical research. This review discusses hydrotropic agents’ structures, the solubilization process, and factors affecting drug solubility. It explores optimizing agent concentrations, the role of computer modeling and QSAR studies, and hydrotropes’ impact on overcoming biological barriers and improving pharmacokinetics and pharmacodynamics. The review highlights hydrotropic compounds’ potential in advancing pharmaceutical formulations and clinical applications.
Nanosponges as a Drug Delivery System: Methods, Characteristics and Applications
Authors: Desai Madhuri Mahesh , Jadhav Sujata Abhay , Koparde Akshada Amit
Published: October 2024

Nanosponges, which are crosslinked polymer nanometers in sized used for drug transport, have a unique three-dimensional appearance. Their versatility lies in their ability to accommodate drugs of various sizes. The research approach, polymer type, and drug content determine the diversity of nanosponges. Nanosponges excel as delivery systems due to their capacity for controlled and targeted drug release. They offer the flexibility to regulate the duration of drug action and residence time. Their biodegradable composition ensures low toxicity and safe usage. Available voids, along with the size of the test molecule, play a crucial role in the efficiency of encapsulation. Nanosponges exhibit numerous applications such as cancer treatment, transportation of enzymes and biocatalysts, oxygen, modification of drug solubility, and immobilization of enzymes. This study emphasizes the preparation method, characterization, influencing factors, drug loading, recent advancements, and patents in the field of nanosponges.
Drug Delivery System That Self-Emulsify: Transportation of Drug From Gut to Target Organs
Authors: Nilesh Jaiswal . , Parulben Mehta .
Published: October 2024

Microemulsions are highly popular for their specific uses, including vivid applications and this is due to their special properties, which include very high interfacial interactions with demonstrated stability from a thermodynamics point of view, and on the other hand, also very low interfacial tension, which is required to solubilize highly immiscible dispersions. This review’s goal is to briefly outline potential uses of micro-emulsion systems, their uses, limitations and possible in-vitro and in-vivo techniques. To characterise such dispersion systems, it is commonly known that adding the right surfactant or surfactant mixture can combine large amounts of two non-dissolving-target liquids, such as water and oil, into a single phase that is macroscopically homogeneous but microscopically heterogeneous. Owing to the advantages of lymph drug delivery, the drug-lipid conjugates, when they enter the lymph route, become an ideal approach for enhancing the absorption of such drugs to combat metastatic cancers of the lymph nodes and their drainage to specific organ systems where the cancer is already spread. As the route of lymph delivery is important where a tumor has already been cancerous, this formulation approach has distinct opportunities to transport needy molecules to cancerous sites in various organs, which also includes the lymph nodes. This review, particularly, lays more stress on an overview of microemulsions in general, the in-vivo and in-vitro characterization methods and potential applications related to target drug delivery via the lymphatic circulatory system.
Global Progress in HIV Therapeutics: An In-Depth Analysis of Dispersible Fixed-Dose Antiretroviral Combination and Their Regulatory Pathways: A Review .
Authors: Mehetre Nitin . , Singh Inderbir  .
Published: October 2024

This review offers a detailed examination of recent advancements in human immunodeficiency virus (HIV) therapeutics, with a particular focus on dispersible fixed-dose combinations (FDCs) of antiretroviral drugs and their associated regulatory pathways. The paper highlights the global progress made in the development and implementation of these formulations, emphasizing their benefits in facilitating administration and enhanced patient adherence. Dispersible FDCs are especially beneficial for pediatric, geriatric, and bedridden patients, as they simplify dosing and improve medication compliance. The review explores the evolution of FDCs, assessing their clinical efficacy and safety profiles while also discussing the regulatory frameworks and approval processes employed by major health authorities across the globe, including the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA), and other key regulatory bodies. By analyzing these aspects, the review aims to illuminate the critical role that FDCs play in optimizing HIV treatment and their broader implications for public health. Antiretroviral therapy has significantly transformed HIV/AIDS management, leading to extended lifespan and a better enhanced well-being for patients. Fixed-dose combinations have simplified treatment regimens and improved adherence. However, the path to developing and approving antiretroviral FDC dispersible tablets is fraught with regulatory challenges. This review not only identifies these challenges but also proposes strategies to overcome them, with the goal of ensuring timely access to safe and effective medications for HIV/AIDS treatment. Through this analysis, the review contributes to understanding how regulatory practices can support the advancement of HIV therapies and enhance global health outcomes.
Innovating Pharmaceuticals: The Rise of 3D printing in Drug Delivery.
Authors: Bagga Harpritkaur . , Aime Aliunui . , Chaudhari Gunjan , Vyas Ujwal .
Published: October 2024

Additionally known as three-dimensional (3D) printing, additive manufacturing has made major advancements possible in the fields of engineering, business, the arts, education, and medical. Thanks to recent developments, it is now possible to print three-dimensional to create complex, useful living tissues, biocompatible substances, cells, and supporting structures are combined. Regenerative medicine is utilizing 3D bioprinting. Additive manufacturing technology, or 3D printing, has been labelled the “next big thing” and is predicted to overtake cell phones in popularity. 3D printers use digital templates to produce actual, three-dimensional items. Adding layers to a print, commonly referred to as additive manufacturing, allows for the use of more than a hundred different materials, including nylon, metal, and plastic. Applications for 3D printing can be found in many different industries, such as industrial design, manufacturing, dental, automotive, aerospace, civil engineering, education, jewellery, footwear, and geographic information systems. It has shown to be a simple and affordable solution for a variety of use cases. Using computer-aided design tools and programming, three-dimensional printing is a sophisticated technique that adds material to a base surface to create three-dimensional things. Additive layer manufacturing, also referred to as 3D printing, is the technique of creating three-dimensional things by depositing or solidifying material one layer at a time. Using a computer-aided design module, pharmaceutical components are organized in a three-dimensional pattern. Afterwards, the constituents are converted into a machine-readable format resembling the surface of a three-dimensional dosage form. 3D printing has been used for jewelry, shoe-making, architecture, engineering & construction, the automotive industry as well as the aerospace field, dentistry and medicine, plus geographic information systems (GIS), civil engineering and education. After that stage of the process is completed, the surface transferred to the machine is then printed in different layers. Bioprinting is an interdisciplinary domain that integrates additive manufacturing with biology and material sciences to manufacture threedimensional structures representative of living organisms. The ability to create biological tissues and organs has attracted considerable attention in biomedical research owing to the rising demand for personalized medicine. This scenario propelled bioprinting forward which received much interest thus triggering comprehensive research efforts by various players such as companies, universities as well as research institutes. The goal of this book is to provide a thorough analysis of the complex and rapidly evolving field of bioprinting by critically analyzing and evaluating the existing scientific literature.
DLipids Selection and Methods of Nanostructured Lipid Carrier for Topical Use
Authors: F Rahman . , E Hendradi . , T Purwanti .
Published: October 2024

Background: The utilization of nanoparticle systems presents a promising means for enhancing the efficacy of specific therapeutic interventions, particularly in topical applications. One of the nanoparticle systems that possesses several advantages is the nanostructured lipid carrier (NLC). It is comprised of solid and liquid lipids that form a lipid matrix with the addition of a surfactant. The utilization of lipids in NLC could impact various physical characteristics and drug release. Objective: This study aims to ascertain the considerations involved in selecting solid and liquid lipids. Method: The research approach to be undertaken is a systematic literature review, which refers to an investigation conducted through the process of identifying, evaluating, and interpreting all pertinent findings related to a study, topic, or phenomenon associated with NLC. Results: the obtained results reveal that various NLC-related articles indicate that polymorphism, the solubility of active compounds, and the ratio of solid and liquid lipids may exert a significant influence on the physical characteristics and release of active compounds. Conclusion: Consideration of the choice between solid and liquid lipids can be made to optimize topical therapeutic efficacy.