bluuebunny/crossref_metadata_2025 huggingface dataset:
ВПРОВАДЖЕННЯ ІНФОРМАЦІЙНО-КОМУНІКАЦІЙНИХ ТЕХНОЛОГІЙ У ТУРИСТИЧНУ ІНДУСТРІЮ КРАЇН ПІВНІЧНОЇ АФРИКИ
Authors: Тимощук О. О.
Published: June 2024

У статті розглядаються напрямки впровадження цифрових технологій у туристичну галузь країн Північної Африки, оскільки їхній ринок дозвіллєвих послуг значно відстає від інших країн Середземномор’я за рівнем проникнення інформаційно-комунікаційних технологій. Зазначається, що цифрові технології пропонують величезний потенціал для максимізації доходів від туризму, збільшення туристичного попиту, покращення якості пропозиції та полегшення комунікації. Окремо виділено новітні цифрові технології, які використовуються в туристичній індустрії провідних країн Північної Африки: по-перше, штучний інтелект і його застосування в топових готелях Марокко та Єгипту відбувається за допомогою сканування сітківки ока або відбитків пальців, що дозволяє підвищити якість обслуговування клієнтів за рахунок послуг персоналізації; по-друге, використання Big Data північно-африканськими туроператорами надає змогу інвентаризувати туристичні ресурси, сприяти розвитку рекреаційних зон, аналізувати туристичні маршрути; по-третє, використання технології блокчейн дозволяє в режимі реального часу відстежувати інформацію про вільні номери в різних готелях країн Північної Африки, оплачувати проживання, бронювати туристичні послуги, керувати ідентифікацією клієнтів; по-четверте, Інтернет речей (IoT) успішно застосовується в індустрії туризму країн Північної Африки для досягнення максимальної відповідності умов подорожей індивідуальним уподобанням мандрівників, що докорінно змінює всю індустрію туризму; по-п’яте, використання мобільних додатків, призначених для мандрівників, забезпечує широкий спектр функцій, зокрема, купівлю авіаквитків, бронювання готелів, навігацію на місцевості, надання довідкової інформації про пам’ятки, рейтинги закладів розміщення. Було підтверджено, що розширення цифрових технологій у поєднанні зі зниженням вартості обладнання покращило надійність, сумісність і взаємозв’язок численних терміналів і програм, що перетворило їх на потужний інструмент, який може принести користь у просуванні та зміцненні стратегія та діяльність індустрії туризму країн Північної Африки.
TEORETYCZNE PODSTAWY ZARZĄDZANIA PROCESAMI W WARUNKACH ZMIANY
Authors: Verbovska L. S. , Fastivskyy G. V. , Yatsko V. M.
Published: June 2024

W artykule zbadano teoretyczne podstawy zarządzania procesowego w warunkach zmian oraz znaczenie wiedzy w zarządzaniu procesowym dla podmiotu gospodarczego. Trafność tego opracowania stanowi ważny element współczesnego podejścia do procesu zarządzania zmianami, wiedzą i procesami biznesowymi, kształtując nie tylko zrozumienie wszystkich procesów zachodzących w strukturze zarządzania, ale także wykorzystanie cyklu Deminga jako procedury wdrażanie systemu zarządzania i zarządzanie procesami w organizacji. Określono znaczenie stosowania podejścia procesowego, ponieważ umożliwi ono ocenę, monitorowanie procesów biznesowych, wprowadzanie zmian poprzez optymalizację lub reengineering, zarządzanie wiedzą i zmianami w organizacji, zgodność systemu rachunkowości zarządczej w procesach biznesowych obniży koszty rozwoju bazy informacyjnej, integracji różnych systemów informatycznych i ich wsparcia. Udowodniono, że ważnym aspektem zmiany jest teoria zmiany Lippitta, która uwzględnia świadomość potrzeby zmiany; rozwój relacji pomiędzy systemem a agentem zmiany; identyfikacja problemów zmian; ustalenie celów zmian, planu działania dla ich osiągnięcia; wdrażanie zmian; personel postrzega zmiany jako takie; stabilizacja; przedefiniowanie relacji agenta zmiany z systemem. Uzyskane badania teoretyczne wykazały, że z punktu widzenia badań rozwoju metodologicznego zastosowanie prezentowanego przez nas narzędzia w procesach biznesowych jest ważnym elementem procesu wdrażania zmian i zarządzania wiedzą w podmiocie gospodarczym. Jednocześnie ustala się, że procesy biznesowe i formalizacja, wiedza o uwarunkowaniach zmian, skuteczne zarządzanie nimi, to podstawowa technologia współczesnego zarządzania, a opisane procesy biznesowe służą jako mapa drogowa dla zainteresowanych stron, właścicieli firm. organizacja i proces biznesowy dotyczący wdrożenia przeprojektowania procesu, jeśli to konieczne, lub na różnych etapach, jest całkiem przydatny zarówno dla interesariuszy, jak i samej organizacji. Dlatego zarządzanie zmianami i wiedzą odgrywa ważną rolę w procesach biznesowych i zarządzaniu nimi, a wybrany temat artykułu jest istotny w aspektach naukowych i stosowanych.
ФІСКАЛЬНІ ЕФЕКТИ МИТНОЇ ПОЛІТИКИ УКРАЇНИ В УМОВАХ ІНТЕГРАЦІЙНИХ ПРОЦЕСІВ
Authors: Мельник В. М. , Руденко В. В. , Євтушенко Н. М.
Published: June 2024

У реаліях сьогодення, в умовах розвитку інтеграційних процесів, активного входження України у світове господарство та загальної лібералізації зовнішньої торгівлі, формування й реалізація митної політики залишається важливим завданням в контексті отримання фіскальних ефектів. Для забезпечення економічного відновлення й зростання необхідно провадити таку митну політику, яка уможливлює ефективне регулювання зовнішньоекономічної діяльності, водночас забезпечуючи стабільні надходження митних платежів до державного бюджету. Відтак необхідно звернути увагу на фіскальні ефекти митної політики в умовах входження до європейського та світового торгівельно-економічного простору.
Стаття присвячена вивченню актуальних питань формування та реалізації митної політики держави, аналізі наслідків функціонування митних союзів та обґрунтуванні фіскальних ефектів для України та країн-членів ЄС у межах митного союзу ЄС.
Специфіка наукових завдань, що становлять предмет дослідження, вимагала використання комплексу спеціальних методів, застосування яких допомогло визначити зміст митної політики, розглянути специфіку її проведення в умовах інтеграції, зокрема при входженні до митних союзів, а також оцінити фіскальні ефекти митної політики України та країн-членів ЄС, що мають спільний митний союз.
У статті досліджено поняття «митна політика» з позиції законотворці і науковців, обґрунтовано її авторське визначення Розглянуто розвиток митної політики в умовах розвитку інтеграційних процесів. Розглянуто переваги та недоліки функціонування митних союзів.
В результаті дослідження доведено, що в Україні з початком входження до зони вільної торгівлі з ЄС та в країнах-членах ЄС при входженні до митного союзу ЄС, відбулося нарощування митних платежів до бюджету при переважанні ефекту «створення» торгівлі. Останній полягає у тому, що після утворення митного союзу і скасування ввізного мита, коли іноземні товари із країн об’єднання стають дешевшими від вітчизняних, а споживачі купують імпортні товари замість вітчизняних, виникає та розширюється імпортний товарний потік, відтак ефективніше використовуються ресурси інтеграційного об’єднання та зростають митні платежі до бюджету.
Inferencia estadística en los textos escolares: una aproximación al pensamiento estadístico
Authors: Rodríguez-Alveal Francisco Enrique , Aguerrea Maitere
Published: June 2024

[Objective] The main purpose of this study was to analyze the activities related to statistical inference present in secondary education textbooks in Chile, and their relationship to the development of statistical thinking. [Methodology] For the purposes of the study, a qualitative approach was used through a content analysis of the secondary education books disseminated free of charge by the Chilean Ministry of Education during the years 2016, 2018, 2020, 2021 and 2022, which were selected using intentional non-probabilistic sampling. [Results] Among the main results obtained, it was found that most of the activities related to statistical inference in the textbooks analyzed had to do with procedures related to the calculation of confidence intervals, without addressing their interpretation in the context of the problem. In addition, it was observed that there were few activities related to informal inference. Likewise, the activities and questions presented in the textbooks do not refer to the formulation of hypotheses or conjectures about the sample data made to guide the formulation of conclusions related to statistical inference. [Conclusions] The findings indicate that despite the fact that confidence intervals are among the topics related to statistical inference in the textbooks, these textbooks are not focused on decision-making at the population level, but rather on description.
Can biophotonic therapy ameliorate the metabolic sequelae of NIDDM?
Authors: Tulp PhD, MD, FACN, CNS Orien L , Einstein, PhD, DSc George P
Published: June 2024

Since antiquity, humans have sought the healing powers of sunshine to resolve many illnesses and restore a sensation of health and wellness. In recent publications, it has been reported that biophotonic treatment resulted in improvements in hemoglobin A1c and SpO2 concentrations in human subjects. In an animal study in which biophotonic treatment was applied to skeletal muscle in two models of Type 2 diabetes (NIDDM/T2DM), biophotonic treatment resulted in normalization of fasting and response plasma glucose concentrations and in an improvement in glycogen synthesis in skeletal muscle, likely secondary at least in part to improved GLUT4 actions and insulin sensitivity resulting in improved peripheral glucose uptake and oxidation and by increases in ATP generation in skeletal muscle. Because the biochemical mechanisms of carbohydrate metabolism and their contributions to the development of NIDDM are similar in both humans and in the animal models studied, the question arises as to whether biophotonic therapy might undergo consideration as an adjunct in the treatment of hyperglycemia, elevated HbA1c, peripheral oxygen delivery and wound healing in clinical management of NIDDM/T2DM. Biophotonic therapies have been widely used in the treatment of various infectious diseases and as an adjunct in anti-aging medicine, but the observations on parameters of intermediary metabolism in humans and animal models of NIDDM/T2DM reflect new findings believed to be of significant importance if applied to the clinical management of obesity, NIDDM and impaired glycemic states in humans.
Perineal groove: more than a rare anomaly, review of the literature
Authors: Moreno Alfonso Julio César , Velásquez Sharom Barbosa , Gutiérrez William Montenegro , Beltrán Mogollón Lina Alejandra , Vela Viviana , Neira Laura , Dávila Lorena Ospina , Amaya Miguel Alejandro Suárez
Published: June 2024

The perineal groove is a rare congenital malformation that mainly affects females. Stephens and Smith first described it in 1968 as a moist groove between the vulvar fork and the anus without alteration of the vestibule, urethral or vaginal introitus, and hypertrophy of the labia minora bordering the groove posteriorly to join or surround the anus. Perineal groove is usually asymptomatic and with spontaneous resolution. Due to its lack of knowledge and scarce documentation in the literature, its diagnosis is often erroneous and patients and their families are subjected to stressful events, unnecessary studies and treatments. A literature review is conducted to increase awareness of the existence, treatment, and prognosis of this medical condition.
Assessing the Determinants of Oral Health-Related Quality of Life Among Male Costa Rican Students: Findings from a Cross-Sectional Study
Authors: Reyes-Umaña Yuliana , Rojas-Bogante Leidy , Stradi-Granados Sonia , Barahona-Cubillo Juan Bautista , Barboza-Solís Cristina
Published: June 2024

To evaluate the association between socioeconomic, psychosocial, and lifestyle factors with Oral Health-Related Quality of Life (OHRQoL) in a sample of adolescent males from Colegio Técnico San Agustín de Cartago - Ciudad de los Niños (St. Augustine’s Technical High School), located in the Cartago Province of Costa Rica. Data for this study were obtained from a descriptive, cross-sectional study conducted in 2019. The sample consisted of 394 adolescent males aged between 12 and 22 years. OHRQoL was assessed using the validated Spanish version of the Oral Health Impact Profile (OHIP-49). The following variables were considered: age, parental education, having a remunerated job, Health-Related Quality of Life (measured via the SF-36 questionnaire), self-esteem (Rosenberg scale), perceived stress (PSS-14), depression (CES-D), physical activity, history of dropping out of school, flossing and tooth-brushing habits, eating snacks between meals, medication intake for illness, having received oral health care instructions, history of dental visits due to pain, frequency of dental visits, history of childhood tooth decay, and access to dental health care during childhood. Qualitative variables were analyzed using the Student's t-test, while Pearson correlation was used for quantitative variables. Multivariable analysis was performed using linear regression. Statistical significance was set at p<0.05 using STATA 14®. Enhanced general health-related quality of life (p<0.01) and early childhood dental attendance (p<0.01) were identified as factors associated with improved OHRQoL. Conversely, having had dental visits for pain (p<0.01), elevated depression symptomatology (p<0.01), and a history of childhood dental cavities (p<0.01) were all associated with worse OHRQoL. This study suggests a link between general and oral health. Experiences during childhood appear to set a standard for adolescence. Lastly, it is crucial to note the significant impact of mental health on the perception of oral health.
A hideg agglutinin betegség diagnosztikája és ellátási gyakorlata
Authors: Brúgós Boglárka , Simon Zsófia , Zsigmond Soós Ildikó , Illés Árpád
Published: June 2024

A hideg agglutinin betegség az autoimmun hemolitikus anémiák ritka altípusa, egy indolens, low-grade lymphoproliferatív betegség, amely nem meríti ki a B-sejtes lymphoma kritériumait. A keringésben kimutatható a vörösvértestek felszínén lévő „I” antigén ellenes, rendszerint IgM típusú autoantitest. Hideg hatására a pentamer szerkezetű antitest a perifériás keringésben az antigénhez kötődve agglutinációt, súlyosabb esetben komplement aktivációt és hemolízist okoz. Vércsoport-szerológiai vizsgálat során erős C3d-pozitivitás igazolható. A betegség tünetei, a klasszikus „fatigue”, fáradékonyság, gyengeség részben a hemolitikus anémia, részben a komplement aktiváció, proinflammatorikus citokin emelkedés következményei. A hideg indukálta, IgM mediálta agglutináció felelős a betegség vaszkuláris tüneteiért (acrocyanosis). A betegség kezelésében B-sejt depléciós és komplentgátló kezelések javasoltak, de nagy, nemzetközi randomizált klinikai vizsgálatok hiányában a kezelésre vonatkozóan csak ajánlások állnak rendelkezésre. Közleményünkben a betegség kivizsgálására és kezelésére vonatkozó ajánlásokat foglaltuk össze.
LGL-leukémia: Dasatinib mellett molekuláris remisszióban lévő chronikus myeloid leukémia ritka szövődménye a splenomegália hátterében
Authors: Timár Botond , Szalóki Gábor , Zajta Erik , Bodó Imre , Szepesi Ágota
Published: June 2024

A nagy granuláris lymphocyta (LGL) leukémia leggyakrabban normál LGL-sejtek expanzióját kiváltó krónikus antigén stimulációt okozó állapotokkal, mint például krónikus vírus infekcióval, autoimmun betegségekkel és elsősorban hematológiai malignitásokkal társul. A bemutatott esetben az LGL-leukémia egy ritka okát, tünetét és diagnosztikai lehetőségeit tárgyaljuk. A várandós nőbetegnél rutin vérvizsgálat során észlelt thrombocytosis és splenomegália hátterében chronikus myeloid leukémia igazolódott. Az interferon terápiával indult kezelést autoimmun pneumonitis miatt, a másodvonalban elindított glivec terápiát pedig súlyos neutropénia és társuló MRSA sepsis miatt kellett elhagyni. Harmadvonalban császármetszés után indított dasatinib terápia 16 hónap elteltével major molekuláris választ eredményezett. A betegség kezdetétől észlelt splenomegalia és neutropenia azonban nem szűnt meg. További kivizsgálás során JAK2, CALR, MPL mutáció nem igazolódott, a beteg a lép biopsziába nem egyezett bele. A splenomegália hátterében végső soron a perifériás vérben észlelt monoclonalis T-LGL-sejtszaporulat és cytotoxikus T-sejtek csontvelői infiltrációja alapján diagnosztizált LGL-leukémia állhat. Míg a klonális LGL lymphocytosis a dasatinib kezeléshez ismerten társuló gyakori jelenség, klinikai tüneteket okozó esetet nem találtunk az irodalomban. Miután az LGL lymphocytosis chronikus myeloid leukémia válaszra kifejtett kedvező hatásáról számolnak be, és betegünknél az LGL-leukémia csak egy könnyen uralható enyhe neutropeniát okozott, így a dasatinib kezelésen egyelőre nem változtattunk.
The effect of thiocetam on the parameters of the nitric oxide system under the conditions of the experimental periodontitis and immobilization stress formation
Authors:   Department of Pathophysiology Danylo Halytsky, Lviv National Medical University, Lviv, Ukraine, Regeda Mykhailo , Olekshij Petro ,   Department of Orthopedic Dentistry, Private Higher Education Institution “Lviv Medical University”, Lviv, Ukraine, Regeda-Furdychko Maaryana ,   Department of Anatomy, Physiology, Pathology, Private Higher Education Institution “Lviv Medical University”, Lviv, Ukraine, Furdychko Lubomur ,   Department of Anatomy, Physiology, Pathology, Private Higher Education Institution “Lviv Medical University”, Lviv, Ukraine, Kolishetska Marta ,   Department of Pathophysiology Danylo Halytsky, Lviv National Medical University, Lviv, Ukraine, Regeda Stepan ,   Department of Surgical and Orthopedic Stomatology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Fil Vitalii ,   Department of Medical and Biological Disciplines, Geography, and Ecology, Drohobych Ivan Franko State Pedagogical University, Drohobych, Ukraine
Published: June 2024

Introduction and aim. The aim of this work is to study the parameters of the nitric oxide (NO) system in the blood of guinea pigs under the conditions of the experimental periodontitis (EP) and immobilization stress (IS) formation and to evaluate the effectiveness of thiocetam use. Material and methods. Experimental studies were performed on 50 guinea pigs (males, body weight 0.18–0.21 kg) which were divided into five groups (10 in each): the first group were intact animals as control; the second experimental group were animals with experimental periodontitis under conditions of immobilization stress (3rd day), the third group included guinea pigs with EP and IS on the 5th day of the combined model process, group IV – animals with EP and IS 15th day (without administration of thiocetam) and group V – animals on the 15th day of experiment with EP and IS after use of thiocetam. Results. As a result of this research, changes in the activity of the NO system in the blood were observed, namely an increase in the level of stable metabolites and an increase in the activity of total NO-synthase, which is accompanied by a compensatory inhibition of the L-arginine activity, and these indicators were most pronounced in the late stages of EP and IS formation. Conclusion. The use of thiocetam showed a corrective effect on the changed variables of NO metabolism in the peripheral blood of guinea pigs under the conditions of the EP and IS development.
Survival outcome and prognostic factors in patients with chemotherapy-naive metastatic castration-resistant prostate cancer treated with abiraterone acetate – real-world experience in Vietnam
Authors:   Department of Tam Hiep Medical Oncology, National Cancer Hospital, Hanoi, Vietnam, Do Tu Anh , Nguyen Thai Hoa Thi ,   Department of No. 2 Medical Oncology, National Cancer Hospital, Hanoi, Vietnam, Nguyen Hau Xuan ,   Oncology Department, Hanoi Medical University, Hanoi, Vietnam, Nguyen Loi Dinh ,   Hanoi Medical University, Hanoi, Vietnam, Nguyen Chu Van ,   Quansu Pathology Department, National Cancer Hospital, Hanoi, Vietnam
Published: June 2024

Introduction and aim. In real life, metastatic castration-resistant prostate cancer patients (mCRPC) had more complex clinical presentation than patients in the COU-AA-302 trial. This study primarily aimed to describe the overall survival of chemotherapy-naive mCRPC treated with abiraterone acetate plus prednisone (AAP). Other relevant outcomes and baseline characteristics of these patients were also evaluated. Material and methods. This retrospective, observational study collected data from chemotherapy-naive mCRPC patients treated with AAP in Vietnam. Kaplan-Meier curves were used to estimate time to treatment failure (TTF), and overall survival (OS). The impact of baseline characteristics on OS was explored using univariate and multivariate Cox proportional hazard models. Results. Data from 65 eligible patients were analyzed. The rate of PSA response was 73.8%, median PSA PFS was 10.5 months (95% CI: 7.4–13.6), median TTF was 15 months (95% CI: 11.1–18.9), and median OS was 24.9 months (95% CI: 18.9–30.9). Shorter OS was significantly associated with a higher Gleason score (≥8), shorter time from ADT start to mCRPC (<12 months), visceral metastases, and <50% PSA decline (p<0.05). Conclusion. Abiraterone acetate plus prednisone is well tolerated and effective for chemotherapy-naive mCRPC patients in clinical practice. Moreover, Gleason score, visceral metastasis, time from ADT start to mCRPC, and PSA response are the independent indicators for predicting the OS of mCRPC patientsin both univariate and multivariate analyses.
ChatGPT in hospital infection prevention and control – assessing knowledge of an AI model based on a validated questionnaire
Authors:   Department of Microbiology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, India, Jawanpuria Ankita , Behera Aruna Rani ,   Department of Microbiology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, India, Dash Chinmaya ,   Department of Microbiology, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, India, Rahman Mohammad Hifz Ur ,   Department of Community Medicine, Manipal Tata Medical College, Manipal Academy of Higher Education, Manipal, India
Published: June 2024

Introduction and aim. An AI model like ChatGPT is a good source of knowledge. We can explore the potential of AI models to complement the expertise of healthcare professionals by providing real-time, evidence-based information in infection prevention and control (IPC). Material and methods. This study involved 110 queries related to IPC, validated by subject experts in IPC. The responses from ChatGPT were evaluated using Bloom’s taxonomy by experienced microbiologists. The scores were divided as 4 as a good response. Statistical analysis was done by correlation coefficient and Cohen’s Kappa. Results. The overall score was 4.33 (95% CI, q1 3.65–q3 4.64) indicating ChatGPT’s substantial IPC knowledge. A good response (i.e.>4 score) was found in 70 (63.6%) questions, while in 10 (9%) questions, it showed a poor response. The poor response was seen in needle stick injury and personal protective equipment (PPE) doffing-related questions. The overall correlations were found to be significant. Cohen’s Kappa confirmed moderate to substantial agreement between evaluators. Conclusion. ChatGPT demonstrated a commendable understanding of IPC principles in various domains and the study identifies specific instances where the model may require further refinement especially in critical scenarios such as needlestick injuries and PPE doffing.
Genetic factors contributing to the development of inguinal hernias – a narrative review
Authors:   Medical School, University of Cyprus, Nicosia, Cyprus, Kalali Datis
Published: June 2024

Introduction and aim. Inguinal hernias are one of the major disorders in the field of general and visceral surgery and can be viewed as multifactorial diseases. Although the molecular mechanism that led to predistortion to inguinal herniation still remain unclear, is well known that defects leading to improper closure of the inguinal canal during fetal development and mechanisms contributing to weaker muscles of the abdominal wall can greatly increase the risk of developing the latter disease. Material and methods. A literature search was performed in all major electronic databases using keywords and Boolean operators to retrieve all available literature related to the topic. Due to the narrative nature of the review, there were no specific inclusion and exclusion criteria. Analysis of the literature. Genetic factors, undoubtedly, can interfere with these mechanisms and therefore play major role in developing hernias. To this end, the present narrative review provides an overview of genes with altered expression and genetic polymorphisms associated with inguinal herniation. Moreover, the results of genome-wide association studies (GWAS) exploring susceptible genetic loci associated with the disease have been reported. Conclusion. Nevertheless, more case-control studies and GWAS need to be conducted in different ethnic populations so as to provide better insights into the topic.
Combined non-surgical and surgical management of misdiagnosed cutaneous sinus tract of endodontic origin – 15 months CBCT follow-up
Authors:   Department of Conservative Dentistry and Endodontics, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India, Makkar Sameer , Rohilla Smriti ,   Department of Conservative Dentistry and Endodontics, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India, Gupta Sandeep ,   Department of Conservative Dentistry and Endodontics, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India, Negi Shabnam ,   Department of Conservative Dentistry and Endodontics, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India, Makkar Monika ,   Department of Prosthodontics, Crown and Bridge, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India
Published: June 2024

Introduction and aim. An extraoral cutaneous sinus tract of endodontic origin represents a skin condition that appears due to an infection that could be primary or secondary to trauma accompanied by alveolar bony changes. It may be easily misdiagnosed and inappropriately treated due to lack of inadequate expertise on part of medical professionals followed by faulty treatment which can complicate the case further. Description of case. This case report intends to highlight a case of a sixteen-year-old male patient referred for an extraoral cutaneous sinus tract misdiagnosed and insufficiently treated by a general physician followed by general dentists for more than a month due to lack of proficiency in the field of endodontics. The clinical and radiographic examinations confirmed the pulpal origin due to trauma related to permanent mandibular incisors. A combination of non-surgical root canal therapy followed by periapical surgery was performed leading to a significant healing of the lesion. Conclusion. Accurate diagnosis is the key to treat draining sinus tracts of endodontic origin. Root canal treatment and endodontic surgery should be used judiciously for effectively eliminating the pathogens thus providing healing and repair mechanisms a chance to achieve the desired result.
A study of etiological spectrum in 106 cases of pancytopenia
Authors:   Department of Pathology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India, Singhal Parul , Mittal Adreena ,   Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh, India, Dixit Ritvija ,   Department of Physiology, Amrita Medical College, Faridabad, Haryana, India
Published: June 2024

Introduction and aim. Pancytopenia is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The aim of this work was to study the etiological spectrum of pancytopenia in the National capital region of India, and evaluate the relationship of pancytopenia with serum vitamin B12 levels. Material and methods. This study is of a prospective and analytical type conducted on patients attending the outpatient and inpatient department of Santosh Medical College and the Saraswathi Institute of Medical Sciences tertiary care centers in NCR. Complete blood counts and peripheral blood smear examination was used for morphological classification and typing of anemia. Bone marrow aspiration and vitamin B12 estimation was performed where required. Results. The maximum number of pancytopenia cases were etiologically attributed to megaloblastic anemia (64.2%) followed by aplastic anemia (19.8%). Malaria was attributed to 6.6% cases of pancytopenia. Iron deficiency anemia and tuberculosis both accounted for 1.9% of cases. each. A history of drug intake and mixed nutritional anemia each contributed to 2.8% of cases. Serum vitamin B12 levels showed a significant relationship with pancytopenic cases. Conclusion. In our study, the main cause of pancytopenia is megaloblastic anemia which responds very well to treatment if diagnosed correctly in time. A detailed hematological assessment along with vitamin B12 levels should be evaluated in all cases of pancytopenia irrespective of the etiological categorization.
The relationship between knowledge levels of HPV and health literacy in youth – an example from Türkiye
Authors:   Dicle University Atatürk Vocational School of Health Services, Diyarbakır, Türkiye, Şen Mehmet Ali , Yakıt Ak Eda ,   Dicle University Atatürk Health Services Vocational School, Diyarbakir, Türkiye
Published: June 2024

Introduction and aim. Human papillomavirus (HPV) is a common infection responsible for many cancers. This study was conducted to determine the relationship between the knowledge level of HPV and the health literacy of youth living in Türkiye. Material and methods. The study sample comprised 543 youth aged 18 and 30 living in Türkiye. The data were assessed with a questionnaire, the human papilloma virus knowledge scale (HPV-KS), and the health literacy scale (HLS) and the correlation between them. Results. 50.6% of the youth informed that they are aware of HPV, and 54% of the youth know about the transmission mode of HPV. It was determined that knowing HPV increased 1.839 times by being a woman, 1.949 times by being married, and 14.339 times by knowing STIs. The HPV-KS total score average of the youth was low at 14.26±7.04, and the total score average of HLS was high at 107.91±16.81. A positive and significant correlation was found between HPV-KS total score, all sub-factor scores, HLS total score, and all sub-factors total score (p<0.001). Conclusion. Information studies on HPV should be increased by taking advantage of the generality of health literacy.
Encapsulation of genistein in glycidylated G3 polyamidoamine dendrimers enables diffusion of genistein through biological membranes and anti-nematode activity of the encapsulate
Authors:   Faculty of Medical Sciences, Rzeszów University of Information Technology and Management, Rzeszów, Poland, Filipowicz-Rachwał Aleksandra , Drozdowska Joanna ,   Faculty of Chemistry, Rzeszów University of Technology, Rzeszów, Poland, Zagórska-Dziok Martyna ,   Faculty of Medical Sciences, Rzeszów University of Information Technology and Management, Rzeszów, Poland, Uram Łukasz ,   Faculty of Chemistry, Rzeszów University of Technology, Rzeszów, Poland, Wołowiec Stanisław ,   Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
Published: June 2024

Introduction and aim. Poorly soluble isoflavonoid genistein is known as an anti-nematode agent and also it decreases the risk of certain types of cancer. The biological activity of genistein is limited mostly by its low solubility. Therefore many attempts to increase genistein solubility in water were reported. We applied a polyamidoamine dendrimer, modified its surface by glycidylation, and used this macromolecule as a guest for genistein. Material and methods. Polyamidoamine dendrimer 3rd generation was substituted with 64 glycidol residues to obtain a macromolecule host for genistein. The stoichiometry of this host-guest complex was determined. The complex was tested for skin model permeability, toxicity on fibroblast (BJ) and keratinocyte (HaCaT) cell lines in vitro and anthelmintic activity on the Caenorhabditis elegans nematode. Results. The partition coefficient of genistein between octanol and water was determined (KO/W). The 1:1 host-guest complex was isolated and used as drug delivery system for genistein delivery. PAMAM G3 glycidyled dendrimer containing genistein indicated an anthelmintic activity at 50 µM concentration. Conclusion. The solubility of genistein in water increases 640 times in presence of an equimolar concentration of the dendrimer. One molecule of host dendrimer encapsulates 3 molecules of genistein. The encapsulate is an efficient anti-nematode formulation.
Tendencias de la ingeniería multimedia: una mirada glocal desde el sector educativo
Authors: Leal-Pabón Jessica Lorena , Rodríguez-Ibáñez Raúl Eduardo , Mendoza-Gafaro Richard Eliseo
Published: June 2024

Este artículo aborda el análisis de la Ingeniería Multimedia en el contexto glocal, con el objetivo de analizar las tendencias y su relación con la solución de necesidades de la industria, así como el desarrollo de la Ingeniería Multimedia en Colombia a través de los programas académicos; este programa académico emerge para satisfacer la creciente demanda de profesionales en tecnologías de la información y comunicación, abarcando software multimedia, diseño gráfico, producción audiovisual, videojuegos, entre otros campos emergentes; a nivel global, universidades líderes como Nanyang Technological University, National University of Singapore, Northeastern University, Zhejiang University y Shanghai Jiao Tong University ofrecen programas relacionados; en América Latina se han identificado tendencias en diseño gráfico y posproducción multimedia, videojuegos y 3D, y web y aplicaciones móviles; universidades como UNIACC, La Salle Noroeste y Universidad de La Rioja reflejan esta evolución; en Colombia, la Ingeniería Multimedia se alinea con tendencias como contenidos multimedia, realidad aumentada, sistemas centrados en el usuario y desarrollo web por el crecimiento de las TIC; actualmente existen 14 programas activos que desarrollan competencias en tecnologías de telecomunicaciones y aplicaciones informáticas para producir y distribuir contenidos audiovisuales; estos programas se ofrecen en modalidad presencial y virtual; la investigación se desarrolló mediante el enfoque cualitativo de tipo documental; obteniendo como conclusión que la Ingeniería Multimedia impacta campos como educación, periodismo, salud y entretenimiento; aportando soluciones multimedia innovadoras en estos sectores, como plataformas de telemedicina, software educativo, realidad virtual para entrenamiento, entre otros; este artículo ofrece una visión integral de las tendencias contemporáneas y el impacto de la disciplina en la región; asimismo, destaca la relevancia de la Ingeniería Multimedia en la industria actual y cómo la formación de profesionales  es decisiva para el avance tecnológico en América Latina.
Damping ratio of stay cable attached with viscous damper and high-damping rubber damper
Authors: Nguyen Duy Thao , Vo Duy Hung , Chau Si Quanh , Nguyen Cung Huy
Published: June 2024

An analytical model for assessing the dynamic performance of a taut cable attached with a viscous damper (VD) and a high-damping rubber damper (HDRD) is presented. The cable bending stiffness, which is commonly disregarded in the literature, was considered in this work and it was found that the bending stiffness contributes significantly to the cable's damping ratio. The damping ratio was highest for the first mode and gradually diminished for higher modes. The proposed model establishes a relationship between the damping ratio and damper parameters, including their locations, viscosity coefficients, spring stiffness factors and material loss factors. This enables determination of the optimal parameters of dampers such that maximum value of the total damping ratio of the cable–damper system can be obtained, providing a helpful tool in cable design.
Determination of Phenolic, Flavonoid Content and Antioxidant Activity of Oil Rose Products
Authors: Kayahan Seda , Gülbağ Fatih , Kaya Yalçın , Altunkanat Hasret
Published: June 2024

Rose and rose products are used as raw materials in many sectors including cosmetics, food and medicine. The Rosa damascena Mill. rose genotype, which is intensively cultivated in the Isparta region of Türkiye, is an important export product. The flower of the plant is main source of raw materials for rose oil, herbal teas and cosmetic products due to its high essential oil and polyphenols contents. In this study, Rosa damascena, Rosa centifolia, Rosa alba L., Rosa alba ‘Semiplena’ genotypes were grown in Yalova, which is an alternative region in terms of agro-climatic conditions from Isparta and its surroundings where rose oil cultivation is carried out in Türkiye. Within the scope of the study, total phenolic matter, total antioxidant activity (DPPH and CUPRAC) and total flavonoid contents of flowers (whole flowers), rose water and wastewater of the genotypes were determined. It is important to identify alternative rose genotypes to R. damascena in Türkiye and their potential for cultivation under different climatic conditions. The highest phenolic content (4115 mg gallic acid equivalent GAE 100 g-1) and DPPH antioxidant activity (4893 mg trolox equivalent TE 100 g-1) values were obtained in R. damascena genotype at the first harvest period. The highest CUPRAC antioxidant activity (34237 mg TE 100 g-1) values were obtained in R. centifolia genotype at the first harvest period. In the second harvest period, the highest phenolic content, DPPH antioxidant activity and CUPRAC antioxidant activity values were determined in R. centifolia genotype. Antioxidant activity, phenolic and flavonoid contents of dried rose flowers were higher than in rose water and wastewater. Rose petals were found to have the potential to be used as an important antioxidant source, while total phenolic matter and antioxidant activity values were found to be low in rose water and wastewater. The harvest period was found to be major factor in oil rose flowers, which can be an important polyphenol source.
Hans Sloane, the reinvention of the museum, and the promotion of Christian knowledge
Authors: Craske Matthew
Published: June 2024

This article argues that Hans Sloane conceived of museums as an aspect of what the laity could achieve in the field of promoting Christian knowledge. This was considered, upon Lockean terms, as being founded in reason. Sloane’s scientific endeavours were, like Robert Boyle before
him, an effort towards rebuilding the nation upon a shared vision of a ‘natural’ faith. This example is contrasted with a spoof museum closely associated with Sloane’s circle, Don Saltero’s Coffee House, which was founded upon a lampoon of a Catholic reliquary and satirised
the concept of the cabinet of curiosities. This argument runs counter to prevailing views of museums as post-Enlightenment institutions intended to oppose the role of faith in society and replace them with secular alternatives.
DOCÊNCIAS ESCRAVA E NOBRE: FILOSOFIA E EDUCAÇÃO
Authors: Santos Gilberto Silva dos , Bello Samuel Edmundo Lopez
Published: June 2024

A partir da discussão filosófica de Friedrich Nietzsche em torno das tipologias escrava e nobre, compomos as docências escrava e nobre como modos de perspectivar discussões no campo da educação. Ao desenvolver um procedimento genealógico, tensionamos valores que sustentam a Pedagogia da Realidade. Para tal analítica, apresentamos discussões acerca da presença discursiva do real no campo educacional. Destarte, discutimos modos de interpelar a nós mesmos, educadores, entre negar e afirmar a vida: as docências escrava e nobre.
PESQUISA COM O COTIDIANO: AÇÃO, PARTICIPAÇÃO E TRANSFORMAÇÃO NA EDUCAÇÃO PÚBLICA
Authors: Eckhardt Fabiana , Silva Fabiano Soares , Simões Renato
Published: June 2024

O presente artigo busca apresentar a Pesquisa com o cotidiano como uma metodologia participativa que, tomando o diálogo como princípio metodológico e epistemológico, balizado pela relação sujeito-sujeito, tem nos permitido compreender o cotidiano como espaço-tempo de reivindicação, contestação, reflexão, elaboração da realidade concreta e produção de conhecimento. Tal compreensão atrelada ao legado da educação popular no Brasil e na América Latina nos auxilia a formular possibilidades em busca da garantia do direito à educação pública, gratuita e de qualidade a crianças, adolescentes, jovens e adultos das classes populares.
APRESENTAÇÃO: apesar dos desafios, 2021 é um ano de celebração
Authors: Moretti Cheron Zanini , Darsie Camilo
Published: June 2024

Apresentação.
Sobre as meninices de Paulo Freire mais do que nunca e as nossas: Entrevista com Walter Omar Kohan
Authors: Lopes Isabela Pereira , Kohan Walter Omar
Published: June 2024

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Atividade Experimental Problematizada: Uma metodologia fundamentada por narrativa autoral
Authors: Gonçalves Fernanda Tarouco , Canto-Dorow Thaís Scotti do , Coutinho Cadidja
Published: June 2024

Este estudo tem como objetivo descrever e analisar os princípios da Atividade Experimental Problematizada (AEP), considerando que o ensino experimental é uma tendência para motivar os estudantes para a aprendizagem em Ciências, em especial quando esse apresenta um caráter mais investigativo. Para tanto, o autor da AEP foi entrevistado e suas respostas foram submetidas à leitura e saturação teórica, emergindo uma Teoria Fundamentada nos Dados. Os achados, deste trabalho, levam à consideração da AEP como uma metodologia eficiente e atrativa para promover autonomia e gerar significados no processo de aprendizagem.
Ensino Médio Integrado e Abandono Escolar: Uma análise do Instituto Federal do Paraná (2017-2019)
Authors: Pelissari Lucas Barbosa , Da Silveira Patrícia , Silva David José de Andrade
Published: June 2024

O artigo objetiva analisar as relações entre o abandono escolar e os arranjos curriculares do Ensino Médio Integrado (EMI) no Brasil, especificamente observando cargas horárias e tempos de duração dos cursos. Para isso, foi investigado um conjunto de 69 cursos do Instituto Federal do Paraná (IFPR), ofertados entre 2017 e 2019. Os dados foram extraídos da Plataforma Nilo Peçanha (PNP) e analisados à luz de metodologia quantitativa própria. Foram apresentadas duas conclusões principais, que poderão contribuir para a formulação de políticas públicas e para pensar os desafios da concepção político-pedagógica da formação humana integral na atual conjuntura educacional do país.
Educação social e saberes necessários: análises a partir de experiências em acolhimento institucional
Authors: Muller Verônica Regina , Natali Paula Marçal , Santos Karine dos
Published: June 2024

Este texto versa sobre os saberes necessários ao educador social, especialmente em casas de acolhimento institucional. Considera-se a experiência das autoras junto a crianças e adolescentes com direitos violados e argumenta-se historicamente sobre a origem da concepção assistencialista que permeia a ação que deveria ser potencialmente pedagógica nestes espaços. Salienta-se a ideia da formação superior, entre outros aspectos necessários aos educadores sociais, pois a qualidade das práticas pedagógicas está intrinsecamente relacionada ao processo formativo dos profissionais envolvidos e, ainda, ao reconhecimento de um sistema de educação social como complemento à garantia do direito à educação.
Atendimento Educacional Hospitalar: atribuições e contribuições da organização do trabalho pedagógico
Authors: Mattei Cirino Leila Cristina , Lima Ferreira Jacques , Antunes de Sá Ricardo
Published: June 2024

Este artigo apresenta uma investigação de abordagem qualitativa do tipo Estado da Arte sobre a relação entre organização do trabalho pedagógico e atendimento educacional hospitalar. Teve o objetivo de mapear e analisar as atribuições e contribuições da organização do trabalho pedagógico no atendimento educacional hospitalar em pesquisas acadêmicas durante período de 2008 a 2018. A análise de dados permitiu identificar que as atribuições estão relacionadas ao processo de ensino e aprendizagem e as estratégias pedagógicas diferenciadas, a partir da ação pedagógica pautada no currículo escolar e nas necessidades educacionais específicas do estudante hospitalizado. Como contribuições, o estudo revelou exceder as questões escolares, pois além da continuidade da vida escolar, contribui no tratamento de saúde e favorece os aspectos biopsicossociais, beneficiando à atenção terapêutica.
Ensino Médio Inovador: os desafios da Educação Integral e (em) Tempo Integral para a juventude
Authors: Bernado Elisangela da Silva , Silva Flavia Gonçalves da , Felix Rosângela Cristina Rocha Passos
Published: June 2024

Este artigo apresenta uma reflexão sobre os desafios da implantação do Ensino Médio Integral e(m) Tempo Integral, Ensino Médio Inovador, desenvolvido pela SEEDUC. Por meio de uma metodologia qualitativa, dialogamos com os principais teóricos da área, as legislações produzidas nos últimos anos e as percepções dos gestores entrevistados. Os resultados são de uma pesquisa realizada na Universidade Federal do Estado do Rio de Janeiro (UNIRIO) nos anos de 2018 e 2019. Consideramos a importância de tratar sobre os desafios das desigualdades e a trajetória da educação em tempo integral no Brasil. De acordo com a percepção dos gestores, apesar dos desafios na sua implementação e continuidade, o EMI contribuiu para a melhoria na qualidade da educação.
Sob os prismas da educação integral e da complexidade: possibilidades para o ensino médio
Authors: De Souza Bezerra Daniella , De Freitas Thaisa Lemos
Published: June 2024

O texto apresenta aproximações entre ensino médio de tempo integral, educação integral e  epistemologia da complexidade. Discute-se o sentido do tempo e da formação destinada à juventude brasileira. Em seguida, discorre-se acerca dos sentidos da educação popular na perspectiva integral. Ao final, aprofunda-se sobre as formas de organização do trabalho pedagógico e curricular na perspectiva complexa, como vias de superação de uma formação resignada diante da realidade.
Sistematización de Alternativas Pedagógicas
Authors: Hamui Sutton Liz , Cadena Beatriz , Herrerías Ramírez Ashanty
Published: June 2024

El sistema escolar latinoamericano estuvo siempre acompañado por experiencias educativas y planteamientos pedagógicos cuestionadores y alternativos, en este artículo se presenta una aproximación inicial al campo de la sistematización de experiencias pedagógicas. Se revisa la propuesta teórico-metodológica que APPeAL ha construido para recuperar la memoria, los saberes, las prácticas y el proyecto de futuro de las comunidades para la formación de las nuevas generaciones. Se presentan los ejes de análisis para caracterizar las tendencias de la educación en América Latina y para ejemplificar, se aborda un ejercicio de sistematización a partir de la propuesta del magisterio oaxaqueño.
La extensión universitaria y la formación en educación
Authors: Cassanello Carina , Sánchez Cecilia , Cano Augustín
Published: June 2024

El siguiente artículo indagará en la propuesta pedagógica del Espacio de Formación Integral (EFI) Pedagogía, Política y Territorio, una experiencia que llevan adelante hace cinco años, docentes del Programa Integral Metropolitano (PIM) y del Instituto de Educación de la Facultad de Humanidades y Ciencias de la Educación, ambos pertenecientes a la Universidad de la República. El mismo tiene como objetivo generar un espacio de formación e intervención para estudiantes de diferentes disciplinas, desde una perspectiva integral. Así, los y las estudiantes, junto con docentes y actores sociales e institucionales, generan prácticas socialmente pertinentes en los territorios de abordaje, donde se ponen a discusión y se problematizan las relaciones y articulaciones que se establecen entre los territorios, los procesos pedagógicos que allí se despliegan y los actores sociales que los producen.