bluuebunny/crossref_metadata_2025 huggingface dataset:
Fast 3D movement of a laser focusing spot behind scattering media by utilizing optical memory effect and optical conjugate planes
Authors: Tran Vinh , Sahoo Sujit K. , Dang Cuong
Published: December 2019

Controlling light propagation intentionally through turbid media such as ground glass or biological tissue has been demonstrated for many useful applications. Due to random scattering effect, one of the important goals is to draw a desired shape behind turbid media with a swift and precise method. Feedback wavefront shaping method which is known as a very effective approach to focus the light, is restricted by slow optimization process for obtaining multiple spots. Here we propose a technique to implement feedback wavefront shaping with optical memory effect and optical 4f system to speedy move focus spot and form shapes in 3D space behind scattering media. Starting with only one optimization process to achieve a focusing spot, the advantages of the optical configuration and full digital control allow us to move the focus spot with high quality at the speed of SLM frame rate. Multiple focusing spots can be achieved simultaneously by combining multiple phase patterns on a single SLM. By inheriting the phase patterns in the initial focusing process, we can enhance the intensity of the focusing spot at the edge of memory effect in with 50% reduction in optimization time. With a new focusing spot, we have two partially overlapped memory effect regions, expanding our 3D scanning range. With fast wavefront shaping devices, our proposed technique could potentially find appealing applications with biological tissues.
Author Correction: From taxonomic deflation to newly detected cryptic species: Hidden diversity in a widespread African squeaker catfish
Authors: Jirsová Dagmar , Štefka Jan , Blažek Radim , Malala John O. , Lotuliakou David E. , Mahmoud Zuheir N. , Jirků Miloslav
Published: December 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Automating sleep stage classification using wireless, wearable sensors
Authors: Boe Alexander J. , McGee Koch Lori L. , O’Brien Megan K. , Shawen Nicholas , Rogers John A. , Lieber Richard L. , Reid Kathryn J. , Zee Phyllis C. , Jayaraman Arun
Published: December 2019

Polysomnography (PSG) is the current gold standard in high-resolution sleep monitoring; however, this method is obtrusive, expensive, and time-consuming. Conversely, commercially available wrist monitors such as ActiWatch can monitor sleep for multiple days and at low cost, but often overestimate sleep and cannot differentiate between sleep stages, such as rapid eye movement (REM) and non-REM. Wireless wearable sensors are a promising alternative for their portability and access to high-resolution data for customizable analytics. We present a multimodal sensor system measuring hand acceleration, electrocardiography, and distal skin temperature that outperforms the ActiWatch, detecting wake and sleep with a recall of 74.4% and 90.0%, respectively, as well as wake, non-REM, and REM with recall of 73.3%, 59.0%, and 56.0%, respectively. This approach will enable clinicians and researchers to more easily, accurately, and inexpensively assess long-term sleep patterns, diagnose sleep disorders, and monitor risk factors for disease in both laboratory and home settings.
Synthesis of 2-alkenylfurans via a Ag(i)-catalyzed tandem cyclization/cross-coupling reaction of enynones with iodonium ylides
Authors: Peng Haiyun , Wan Yinbo , Zhang Yu , Deng Guisheng
Published: December 2019

A silver(i)-catalyzed tandem cyclization/cross-coupling reaction of enynones with iodonium ylides to construct carbon–carbon double bonds has been developed.
A novel molecular tube fully modified at one end: selective inclusion of cis-unsaturated fatty acid esters
Authors: Kogame-Asahara Chizuru , Ito Shogo , Iguchi Hitomi , Kazama Ai , Shigemitsu Hajime , Kida Toshiyuki
Published: December 2019

A cyclodextrin tube with one fully modified and one unmodified end selectively includes cis-unsaturated fatty acid esters.
Solution-mediated and single-crystal to single-crystal transformations of cucurbit[6]uril host–guest complexes with dopamine
Authors: Danylyuk Oksana , Worzakowska Marta , Osypiuk-Tomasik Joanna , Sashuk Volodymyr , Kedra-Krolik Karolina
Published: December 2019

The structural transformations of cucurbit[6]uril–dopamine complexes are associated with loss of water molecules either from the macrocyclic cavity or from the crystal lattice.
The incorporation of heterovalent copper-oxo and copper-halide clusters for the fabrication of three porous cluster organic frameworks: syntheses, structures and iodine adsorption/release study
Authors: Liu Jin-Hua , Zhang Jing , Zhao Dan , Lin Li-Dan , Sun Yan-Qiong , Li Xin-Xiong , Zheng Shou-Tian
Published: December 2019

Three porous cluster organic frameworks constructed from the paddle-wheel Cu2(CO2)4 and cubane-like Cu4I4 clusters have been synthesized and characterized. Interestingly, compound 2 shows moderate gas uptake ability and I2 adsorption/release feature.
An asymmetric aluminum active quantum plasmonic device
Authors: Mokkath Junais Habeeb , Henzie Joel
Published: December 2019

Plasmonic metal nanostructures support intense nanoscale electromagnetic hotspots that can be modulated in an active plasmonic device.
Structure, elastic characteristic, ideal strengths, and phonon stability of binary uranium intermetallic UGe3 of AuCu3-type
Authors: Yang Jin-Wen , An Li
Published: December 2019

No imaginary vibration frequencies can be observed along any high symmetry directions of the Brillouin zone (BZ), confirming that the UGe3 intermetallic compound is dynamically stable.
Dissociative photodetachment dynamics of the oxalate monoanion
Authors: Gibbard J. A. , Castracane E. , Shin A. J. , Continetti R. E.
Published: December 2019

Photoelectron–photofragment coincidence spectroscopy is used to investigate the dissociative photodetachment of the oxalate monoanion, which results in HOCO + CO2.
Correction: A new non-fullerene acceptor based on the combination of a heptacyclic benzothiadiazole unit and a thiophene-fused end group achieving over 13% efficiency
Authors: Zhang Yunqiang , Cai Fangfang , Yuan Jun , Wei Qingya , Zhou Liuyang , Qiu Beibei , Hu Yunbin , Li Yongfang , Peng Hongjian , Zou Yingping
Published: December 2019

Correction for ‘A new non-fullerene acceptor based on the combination of a heptacyclic benzothiadiazole unit and a thiophene-fused end group achieving over 13% efficiency’ by Yunqiang Zhang et al., Phys. Chem. Chem. Phys., 2019, DOI: 10.1039/c9cp05015a.
Heteroatom substituted zeolite FAU with ultralow Al contents for liquid-phase oxidation catalysis
Authors: Bregante Daniel T. , Tan Jun Zhi , Sutrisno Andre , Flaherty David W.
Published: December 2019

Titanium-substituted FAU stabilizes aromatic alkenes to greater extents than BEA and mesoporous silica.
A systematic theoretical study of the water gas shift reaction on the Pt/ZrO2 interface and Pt(111) face: key role of a potassium additive
Authors: Wang Yan-Xin , Wang Gui-Chang
Published: December 2019

K can enhance the activity of the WGSR on the Pt40/ZrO2 model by reducing both the H2O and COOH dissociation barriers.
In vivo evaluation of the toxic and genotoxic effects of exposure to cobalt nanoparticles using Drosophila melanogaster
Authors: Alaraby Mohamed , Demir Esref , Domenech Josefa , Velázquez Antonia , Hernández Alba , Marcos Ricard
Published: December 2019

Nanomaterials in general and cobalt nanoparticles (CoNPs) in particular are of great interest not only because of their multiple applications and environmental impact, but also for their potential toxicity and safety issues.
Protection by pure and genistein fortified extra virgin olive oil, canola oil, and rice bran oil against acetic acid-induced ulcerative colitis in rats
Authors: Tanideh Nader , Sadeghi Fatemeh , Amanat Sasan , Firoozi Donya , Noorafshan Ali , Iraji Aida , Koohi-Hosseinabadi Omid
Published: December 2019

Conjugation of genistein and dietary oils improves the anti-inflammatory and antioxidant effects of genistein on colitis in rats.
A self-encapsulated broadband phototransistor based on a hybrid of graphene and black phosphorus nanosheets
Authors: Zhou Guigang , Li Zhongjun , Ge Yanqi , Zhang Han , Sun Zhenhua
Published: December 2019

An air-stable, high-performing, broadband phototransistor employing a hybrid of graphene and BP nanosheets is fabricated using a facile process.
A new amplification strategy for a quartz crystal microbalance miRNA sensor based on selective interactions between a metal–organic framework and miRNA
Authors: Ma Ding , Zheng Sheng-Run , Fan Jun , Cai Song-Liang , Dai Zong , Zou Xiao-Yong , Teng Shao-Hua , Zhang Wei-Guang
Published: December 2019

UiO-66 is used as an effective amplifier in a QCM miRNA sensor to detect Let-7a.
Three-dimensional near-field analysis through peak force scattering-type near-field optical microscopy
Authors: Wang Haomin , Li Jiahan , Edgar James H. , Xu Xiaoji G.
Published: December 2019

Peak force scanning near-field optical microscopy (PF-SNOM) is instrumental in exploring tomographic polaritonic behaviors of two-dimensional (2D) materials at the nanoscale.
Magnetic force fields of isolated small nanoparticle clusters
Authors: Iacovita C. , Hurst J. , Manfredi G. , Hervieux P. A. , Donnio B. , Gallani J. L. , Rastei M. V.
Published: December 2019

The usage of magnetic nanoparticles (NPs) in applications necessitates a precise mastering of their properties at the single nanoparticle level.
The journey of lithium ions in the lattice of PNb9O25
Authors: Yu Haoxiang , Zhang Jundong , Zheng Runtian , Liu Tingting , Peng Na , Yuan Yu , Liu Yufei , Shu Jie , Wang Zhen-Bo
Published: December 2019

Evidence for the movement of inserted lithium ions in the insertion host PNb9O25 is provided according to the variation for reflection intensities.
Intrinsic poorly-crystallized Fe5O7(OH)·4H2O: a highly efficient oxygen evolution reaction electrocatalyst under alkaline conditions
Authors: Ding Xiaoteng , Cui Wei , Zhu Xiaohua , Zhang Jianwei , Niu Yusheng
Published: December 2019

A novel low-crystallized Fe5O7(OH)·4H2O electrocatalyst was fabricated and it demonstrates excellent OER activity, outperforming most of the reported Fe-based electrocatalysts.
Sulfonic SiO2 nanocolloid doped perfluorosulfonic acid films with enhanced water uptake and inner channel for IPMC actuators
Authors: Han Yubing , Wang Fang , Li Hongkai , Meng Erchao , Fang Shaoming , Zhao Ansha , Guo Dongjie
Published: December 2019

Sulfonic SiO2 nanocolloids are prepared and doped into perfluorosulfonic acid film for making IPMC actuator with higher levels of actuation behaviors.
Triarylethylene-indolin-2,3-dione molecular conjugates: design, synthesis, docking studies and anti-proliferation evaluation
Authors: Kumar Sumit , Palma Gabriella , Perumal Shanen , Kaur Mandeep , Singh-Pillay Ashona , Raj Raghu , Singh Parvesh , Kumar Vipan
Published: December 2019

A series of 1H-1,2,3-triazole-linked ospemifene–isatin and O-methylated ospemifene–isatin conjugates were synthesized and assayed for their anti-proliferative activities against estrogen-responsive as well as estrogen-non-responsive cells.
Lactobacillus fermentumHFY06 reduced CCl4-induced hepatic damage in Kunming mice
Authors: Li Fang , Lu De-Yun , Zhong Qiu , Tan Fang , Li Wenfeng , Liao Wei , Zhao Xin
Published: December 2019

This study was conducted to investigate the preventative effect ofLactobacillus fermentumHFY06 on carbon tetrachloride (CCl4)-induced liver injury in Kunming mice.
Developing a screen-printed graphite–polyurethane composite electrode modified with gold nanoparticles for the voltammetric determination of dopamine
Authors: Cervini Priscila , Mattioli Isabela A. , Cavalheiro Éder T. G.
Published: December 2019

A screen-printed modified composite electrode (SPGPUE) was prepared with graphite–polyurethane ink containing gold nanoparticles (AuNPs), resulting in a sensor with improved sensitivity regarding the unmodified device in dopamine determination.
Efficient tri-metallic oxides NiCo2O4/CuO for the oxygen evolution reaction
Authors: Mugheri Abdul Qayoom , Tahira Aneela , Aftab Umair , Bhatti Adeel Liaquat , Memon Nusrat Naeem , Memon Jamil-ur-Rehman , Abro Muhammad Ishaque , Shah Aqeel Ahmed , Willander Magnus , Hullio Ahmed Ali , Ibupoto Zafar Hussain
Published: December 2019

In this study, a simple approach was used to produce nonprecious, earth abundant, stable and environmentally friendly NiCo2O4/CuO composites for the oxygen evolution reaction (OER) in alkaline media.
Trisulfur radical anion-triggered stitching thienannulation: rapid access to largely π-extended thienoacenes
Authors: Su Feng , Chen Shuqi , Mo Xiaogang , Wu Kongchuan , Wu Jiajun , Lin Weidong , Lin Zhiwei , Lin Jianbin , Zhang Hui-Jun , Wen Ting-Bin
Published: December 2019

A facile stitching thienannulation between acetylenic rylene dyes and S3˙− for rapid synthesis of largely π-extended thienoacenes was developed.
Scalable and energy-efficient synthesis of CoxP for overall water splitting in alkaline media by high energy ball milling
Authors: Xue Hongyao , Zhang Haiqin , Fricke Sebastian , Lüther Marco , Yang Zijiang , Meng Alan , Bremser Wolfgang , Li Zhenjiang
Published: December 2019

Earth-abundant catalysts based on transition metal phosphides (TMPs) such as CoxP have recently gained a lot of attention in the field of electrocatalysis and are usually acquired by chemical synthesis.
Rechargeable Zn-ion batteries with high power and energy densities: a two-electron reaction pathway in birnessite MnO2 cathode materials
Authors: Li Guanzhou , Huang Zongxiong , Chen Jinbiao , Yao Fu , Liu Jianping , Li Oi Lun , Sun Shuhui , Shi Zhicong
Published: December 2019

As one of the most promising next-generation safe and green energy storage technologies, aqueous Zn-ion batteries have attracted considerable attention in recent years.
Rituximab conjugated iron oxide nanoparticles for targeted imaging and enhanced treatment against CD20-positive lymphoma
Authors: Song Lina , Chen Yi , Ding Jiali , Wu Haoan , Zhang Wei , Ma Ming , Zang Fengchao , Wang Zhongqiu , Gu Ning , Zhang Yu
Published: December 2019

The Fe3O4-PEG-nAb multivalent nanoprobes provide a possible avenue to improve the cancer therapy of rituximab towards clinical application.
Comment on “Zero-thermal-quenching and photoluminescence tuning with assistance of carriers from defect cluster traps” by Chen et al., J. Mater. Chem. C, 2018, 6, 10687–10692
Authors: Xiao Yu , Hao Zhendong
Published: December 2019

Chen et al. (J. Mater. Chem. C, 2018, 6, 10687–10692) reported that the zero-thermal-quenching behavior of Tb3+ was the compensation of different trap depths. In this comment, we argue that this unique behavior is just an intrinsic property of Tb3+.
Reply to ‘Comment on “Zero-thermal-quenching and photoluminescence tuning with the assistance of carriers from defect cluster traps”’
Authors: Chen Yali , Yu Binxun , Gou Jing , Liu Shengzhong Frank
Published: December 2019

In this response to the comments on our article, a series of Sr8Zn1−xSc(PO4)7:12%Tb3+ (SZ1−xSPO:12%Tb3+) phosphors were synthesized, and their photoluminescence behavior confirmed that zinc vacancy defects play a vital role in the SZ1−xSPO:12%Tb3+ phosphor.
Characterization of cathepsin S exosites that govern its elastolytic activity
Authors: Andrault Pierre-Marie , Panwar Preety , Brömme Dieter
Published: December 2019

We have previously determined that the elastolytic activities of cathepsins (Cat) K and V require two exosites sharing the same structural localization on both enzymes. The structural features involved in the elastolytic activity of CatS have not yet been identified. We first mutated the analogous CatK and V putative exosites of CatS into the elastolytically inactive CatL counterparts. The modification of the exosite 1 did not affect the elastase activity of CatS whilst mutation of the Y118 of exosite 2 decreased the cleavage of elastin by ∼70% without affecting the degradation of other macromolecular substrates (gelatin, thyroglobulin). T06, an ectosteric inhibitor that disrupt the elastolytic activity of CatK, blocked ∼80% of the elastolytic activity of CatS without blocking the cleavage of gelatin and thyroglobulin. Docking studies showed that T06 preferentially interacts with a binding site located on the Right domain of the enzyme, outside of the active site. The structural examination of this binding site showed that the loop spanning the L174N175G176K177 residues of CatS is considerably different from that of CatL. Mutation of this loop into the CatL-like equivalent decreased elastin degradation by ∼70% and adding the Y118 mutation brought down the loss of elastolysis to ∼80%. In addition, the Y118 mutation selectively reduced the cleavage of the basement membrane component laminin by ∼50%. In summary, our data show that the degradation of elastin by CatS requires two exosites where one of them is distinct from those of CatK and V whilst the cleavage of laminin requires only one exosite.
The Bubble Noise Technique for Speech Perception Research
Authors: Mandel Michael I. , Grover Vikas , Zhao Mengxuan , Choi Jiyoung , Shafer Valerie L.
Published: December 2019

Purpose

The “bubble noise” technique has recently been introduced as a method to identify the regions in time–frequency maps (i.e., spectrograms) of speech that are especially important for listeners in speech recognition. This technique identifies regions of “importance” that are specific to the speech stimulus and the listener, thus permitting these regions to be compared across different listener groups. For example, in cross-linguistic and second-language (L2) speech perception, this method identifies differences in regions of importance in accomplishing decisions of phoneme category membership. This research note describes the application of bubble noise to the study of language learning for 3 different language pairs: Hindi English bilinguals' perception of the /v/–/w/ contrast in American English, native English speakers' perception of the tense/lax contrast for Korean fricatives and affricates, and native English speakers' perception of Mandarin lexical tone.

Conclusion

We demonstrate that this technique provides insight on what information in the speech signal is important for native/first-language listeners compared to nonnative/L2 listeners. Furthermore, the method can be used to examine whether L2 speech perception training is effective in bringing the listener's attention to the important cues.
Referenceless single‐loop CDR with a half‐rate linear PD and frequency acquisition technique
Authors: Kim H.R. , Chun J.‐H.
Published: December 2019

A referenceless single‐loop clock and data recovery (CDR) circuit with a half‐rate linear phase detector (PD) and an inherent frequency acquisition technique are introduced. Cycle‐slip in the half‐rate linear PD and its relationship with the frequency acquisition are described in detail. The single‐loop CDR consists of a conventional phase‐tracking loop and a frequency‐tracking unit, referred to as the cycle‐slip detector. The proposed CDR is fabricated in a 28 nm CMOS process and achieves a wide capture range of 2.6 Gb/s for a PRBS31 pattern. The RMS and peak‐to‐peak jitter of the recovered clock are and , respectively, at 8 Gb/s. The high frequency jitter tolerance is measured as . The CDR occupies and consumes 26 mW at 8 Gb/s from a 1.0 V supply.
Robust transceiver design based on switched preprocessing for K‐pair MIMO interference channels
Authors: Han Hui , Cai Yunlong , Zhao Ming‐Min , Shi Qingjiang
Published: December 2019

In this work, the authors propose a transceiver design strategy based on switched preprocessing (SP) for interference management in K‐pair MIMO interference channels. Each transmitter performs SP by using a small number of permutation matrices to allocate the entries of its precoder output vector on different transmit antennas. Each arrangement of permutation matrices among the K transmitters gives rise to a set of K parallel point‐to‐point transceivers, referred to as MIMO latent transceiver set (MLTS). Based on the given channel state information (CSI), the optimum MLTS among the available ones is chosen by minimising the squared Euclidean distance between the pre‐estimated noiseless received vector and the true transmit symbol vector. In addition, they consider two CSI error models, i.e. the stochastic error model and the norm‐bounded error model, and for each type they propose robust algorithms for the design of the MLTS associated to the different choices of permutation matrices, which are based on minimising various types of mean square error criteria. A detailed study of computational complexity for the proposed SP‐based MIMO transceiver design algorithms is carried out. Simulation results verify the effectiveness of the new SP‐based designs for MIMO interference channels.
Novel modified phase‐shift modulation strategy for isolated AC–DC power converters
Authors: Llomplat Marcelo , Bosso Jonathan E. , Carballo Roberto E. , García Guillermo O.
Published: December 2019

Different power converter topologies are used to perform the energy exchange between an AC grid and a DC source belonging to a hybrid electric micro‐grid. A single‐phase single‐stage isolated AC–DC power converter is one of them. Moreover, this power converter can operate under different modulation strategies. The phase‐shift modulation (PSM) strategy is capable of varying the phase between the voltages applied to the high‐frequency transformer terminals of the power converter in order to control the energy flow in both directions. Based on the PSM strategy, this study presents a novel modified PSM strategy capable of controlling the power flow in both directions and obtaining a current with low total harmonic distortion and a power factor close to 1 for the entire operating range on the AC side. Considering the novel modulation strategy to be proposed, a comparison of three PSM‐based modulation strategies was carried out taking into account the total harmonic distortion of current injected into the AC grid, the power factor and the average power transferred. A theoretical analysis was carried out and the results obtained were validated by means of experimental results.
Performance of the matched filter in sonar systems having time variable gain
Authors: Rashed Muhammad Salman , Meijer Marco , Teal Paul D.
Published: December 2019

Acoustic wave propagation incurs a loss in an underwater acoustic channel. In sonar systems, a time variable gain (TVG) is used to compensate for this loss. The channel noise in the received signal is assumed to be white and stationary. The TVG transforms the noise in the received signal so that it is still white but no longer stationary. The authors calculate the signal‐to‐noise ratio (SNR) improvement at the output of a matched filter based on white, stationary noise, and compared this with the output of a filter specially designed to match the signal when the noise is altered by TVG. The results reveal that there is a small SNR improvement for longer codes at short ranges with the filter . They study the sensitivity of the sidelobes to a timing mismatch in applying the TVG. Using , the degradation of the correlation sidelobes is considerable. In most cases, it appears that designing the filter to account for non‐stationary of the noise is not warranted, which is a novel conclusion. Regardless of the receiver filter, accuracy in applying the TVG is still important, as even a slight mismatch in its application can be detrimental.
Testing massive star evolution, star-formation history, and feedback at low metallicity
Authors: Fulmer Leah M. , Gallagher John S. , Hamann Wolf-Rainer , Oskinova Lida M. , Ramachandran Varsha
Published: December 2019

Context.The supergiant ionized shell SMC-SGS 1 (DEM 167), which is located in the outer Wing of the Small Magellanic Cloud (SMC), resembles structures that originate from an energetic star-formation event and later stimulate star formation as they expand into the ambient medium. However, stellar populations within and surrounding SMC-SGS 1 tell a different story.

Aims.We present a photometric study of the stellar population encompassed by SMC-SGS 1 in order to trace the history of such a large structure and its potential influence on star formation within the low-density, low-metallicity environment of the SMC.

Methods.For a stellar population that is physically associated with SMC-SGS 1, we combined near-ultraviolet (NUV) photometry from the Galaxy Evolution Explorer with archival optical (V-band) photometry from the ESO Danish 1.54 m Telescope. Given their colors and luminosities, we estimated stellar ages and masses by matching observed photometry to theoretical stellar isochrone models.

Results.We find that the investigated region supports an active, extended star-formation event spanning ∼25−40 Myr ago, as well as continued star formation into the present. Using a standard initial mass function, we infer a lower bound on the stellar mass from this period of ∼3 × 104 M⊙, corresponding to a star-formation intensity of ∼6 × 10−3 M⊙kpc−2yr−1.

Conclusions.The spatial and temporal distributions of young stars encompassed by SMC-SGS 1 imply a slow, consistent progression of star formation over millions of years. Ongoing star formation, both along the edge and interior to SMC-SGS 1, suggests a combined stimulated and stochastic mode of star formation within the SMC Wing. We note that a slow expansion of the shell within this low-density environment may preserve molecular clouds within the volume of the shell, leaving them to form stars even after nearby stellar feedback expels local gas and dust.
NOEMA redshift measurements of bright Herschel galaxies
Authors: Neri R. , Cox P. , Omont A. , Beelen A. , Berta S. , Bakx T. , Lehnert M. , Baker A. J. , Buat V. , Cooray A. , Dannerbauer H. , Dunne L. , Dye S. , Eales S. , Gavazzi R. , Harris A. I. , Herrera C. N. , Hughes D. , Ivison R. , Jin S. , Krips M. , Lagache G. , Marchetti L. , Messias H. , Negrello M. , Perez-Fournon I. , Riechers D. A. , Serjeant S. , Urquhart S. , Vlahakis C. , Weiß A. , van der Werf P. , Yang C. , Young A. J.
Published: December 2019

Using the IRAM NOrthern Extended Millimeter Array (NOEMA), we conducted a program to measure redshifts for 13 bright galaxies detected in the Herschel Astrophysical Large Area Survey with S500 μm ≥ 80 mJy. We report reliable spectroscopic redshifts for 12 individual sources, which are derived from scans of the 3 and 2 mm bands, covering up to 31 GHz in each band, and are based on the detection of at least two emission lines. The spectroscopic redshifts are in the range 2.08 <  z <  4.05 with a median value of z = 2.9 ± 0.6. The sources are unresolved or barely resolved on scales of 10 kpc. In one field, two galaxies with different redshifts were detected. In two cases the sources are found to be binary galaxies with projected distances of ∼140 kpc. The linewidths of the sources are large, with a mean value for the full width at half maximum of 700 ± 300 km s−1 and a median of 800 km s−1. We analyze the nature of the sources with currently available ancillary data to determine if they are lensed or hyper-luminous (LFIR >  1013 L⊙) galaxies. We also present a reanalysis of the spectral energy distributions including the continuum flux densities measured at 3 and 2 mm to derive the overall properties of the sources. Future prospects based on these efficient measurements of redshifts of high-z galaxies using NOEMA are outlined, including a comprehensive survey of all the brightest Herschel galaxies.
Two-dimensional simulations of coronal rain dynamics
Authors: Martínez-Gómez D. , Oliver R. , Khomenko E. , Collados M.
Published: December 2019

Context. Coronal rain often comes about as the final product of evaporation and condensation cycles that occur in active regions. Observations show that the condensed plasma falls with an acceleration that is less than that of free fall.

Aims. We aim to improve the understanding of the physical mechanisms behind the slower than free-fall motion and the two-stage evolution (an initial phase of acceleration followed by an almost constant velocity phase) detected in coronal rain events.

Methods. Using the MANCHA3D code, we solve the 2D ideal magnetohydrodynamic equations. We represent the solar corona as an isothermal vertically stratified atmosphere with a uniform vertical magnetic field. We represent the plasma condensation as a density enhancement described by a 2D Gaussian profile. We analyse the temporal evolution of the descending plasma and study its dependence on such parameters as density and magnetic field strength.

Results. We confirm previous findings that indicate that the pressure gradient is the main force that opposes the action of gravity and slows down the blob descent, and that larger densities require larger pressure gradients to reach the constant speed phase. We find that the shape of a condensation with a horizontal variation of density is distorted during its fall because the denser parts of the blob fall faster than the lighter ones. This is explained by the fact that the duration of the initial acceleration phase and, therefore, the maximum falling speed attained by the plasma, increases with the ratio of blob to coronal density. We also find that the magnetic field plays a fundamental role in the evolution of the descending condensations. A strong enough magnetic field (greater than 10 G in our simulations) forces each plasma element to follow the path given by a particular field line, which allows for the description of the evolution of each vertical slice of the blob in terms of 1D dynamics, without the influence of the adjacent slices. In addition, under the typical conditions of the coronal rain events, the magnetic field prevents the development of Kelvin-Helmholtz instability.
Le réseau européen de référence pour les maladies neuromusculaires rares (EURO-NMD)
Authors: Evangelista Teresinha
Published: December 2019

Il est bien établi que le nombre réduit de patients atteints d’une maladie rare (MR), la dispersion géographique de ceux-ci ainsi que le nombre réduit d’experts constituent des obstacles au diagnostic, à l’accès aux soins, à la recherche et au perfectionnement de l’expertise médicale. Pour surmonter ces obstacles, il est nécessaire de mettre en contact les experts du domaine et de mutualiser les ressources via des réseaux. Les réseaux européens de référence (ERNs), réseaux de professionnels de santé dispensant des soins hautement spécialisés, sont une initiative de la Commission Européenne (CE) visant à surmonter les problèmes liés aux MR et à améliorer l’accès au diagnostic, au traitement et aux soins pour les patients à travers l’Union Européenne.
Vivian Maier, ni vue ni connue
Authors: Samacher Jean-Yves , Samacher Robert
Published: December 2019

Il existe des formes de délire qui ne trouvent pas d’expression directe dans le langage, mais que l’on peut repérer par certains comportements, des façons d’être singulières, excentriques. À partir de la vie et de l’œuvre de Vivian Maier, garde d’enfants anonyme devenue photographe de renommée internationale après son décès, en 2009, nous tenterons de mettre en évidence l’existence d’une « psychose à bas bruits ». Nous insisterons particulièrement sur les points de bascule constitués par les sautes d’humeur et la désadaptation progressive, chez un sujet s’efforçant de garder le secret sur lui-même comme sur sa pratique personnelle.
La politique, l’Autre de la psychanalyse. Terreur, haine, radicalisation
Authors: Prado de Oliveira Luiz Eduardo
Published: December 2019

À l’occasion d’actions terroristes récentes, nous montrons que depuis longtemps des psychanalystes se sont intéressés à la terreur, dès l’ascension du nazisme jusqu’à la guerre du Vietnam, dès la terreur des femmes et des enfants face aux bombardements aériens jusqu’aux situations cliniques où s’installe la peur. Ce faisant, nous évoquons différents auteurs ayant traité de la terreur, qui peuvent enrichir la psychanalyse, en éclaircissant ses difficultés actuelles face aux formes manifestes de terreur sociale.
Humeurs sénescentes : la question narcissique dans le vieillissement
Authors: Rexand-Galais Franck
Published: December 2019

Développée en premier par Balier (1976), la théorie du vieillissement narcissique constitue une clef de compréhension incontournable des enjeux psychopathologiques du vieillissement et de la question de l’humeur sénescente en particulier. Alors que l’abord contemporain (American Psychiatric Association, 2013) produit une mise en forme catégorielle des troubles de l’humeur toujours plus affinée qui est loin de correspondre aux spécificités de la sénescence (Batelaan et coll., 2012 ; Calvet et Clément, 2014), la théorie narcissique du vieillissement permet de restituer une cohérence explicative aux troubles du vieillissement en rendant compte de leurs liens. À travers sa prise en compte des larges conséquences des atteintes subies par le narcissisme au cours de la vieillesse, elle donne au narcissisme un rôle central dans le fonctionnement psychique sénescent. La reprise de la pensée de Balier à la lumière de ses sources (Kestemberg et Kestemberg, 1966) et des éclairages les plus contemporains (Beatson et coll., 2016) permet d’approfondir la théorie en la prolongeant et d’isoler une « désorganisation limite sénescente partagée » et ses différents destins. La prise en compte clinique de ce fonctionnement limite au cours du vieillissement et de son devenir est d’une importance centrale dans la prise en charge psychothérapeutique des troubles du vieillissement.
Häufigkeit eines Risikos für Mangelernährung bei Patienten in onkologischen Schwerpunktpraxen – eine Querschnittserhebung
Authors: Hauner Hans , Kocsis Alexandra , Jaeckel Benjamin , Martignoni Marc , Hauner Dagmar , Holzapfel Christina
Published: December 2019

Hintergrund Daten zum Ernährungsstatus von Patienten mit Tumorerkrankungen in ambulanten Einrichtungen fehlen in Deutschland. Die durchgeführte Querschnittserhebung bei Patienten mit Tumorerkrankungen hatte daher das Ziel, die Häufigkeit eines Risikos für Mangelernährung bei Tumorpatienten in onkologischen Schwerpunktpraxen zu ermitteln.

Methode Patienten mit Tumorerkrankungen wurden mittels eines standardisierten Fragebogens konsekutiv in 17 onkologischen Schwerpunktpraxen in Südbayern zwischen Juni 2017 und Mai 2018 befragt. Neben Fragen zum Gesundheitszustand und zur Ernährung wurden die validierten Screening-Fragebögen Malnutrition Universal Screening Tool (MUST) und Nutritional Risk Screening Tool-2002 (NRS-2002) zur Erfassung des Risikos für Mangelernährung (primärer Endpunkt) eingesetzt. Die statistische Auswertung erfolgte deskriptiv.

Ergebnisse Insgesamt wurden Datensätze von 765 Patienten (60,9 % Frauen) ausgewertet. Die Teilnehmer waren im Mittel 63,1 ± 13,1 Jahre alt, der durchschnittliche Body-Mass-Index (BMI) betrug 25,2 ± 5,1 kg/m2. Bei Anwendung des MUST-Fragebogens hatten 15,4 % der Teilnehmer ein mittleres und 19,5 % ein hohes Risiko für eine Mangelernährung. Darunter wiesen am häufigsten Patienten mit Tumoren des Verdauungssystems ein Risiko für eine Mangelernährung auf (46,6 %). Die Kriterien für ein Mangelernährungsrisiko nach dem NRS-2002-Score (≥ 3 Punkte) erfüllten hingegen 29,1 % der befragten Patienten. Weniger als ein Drittel der Tumorpatienten hatte nach Diagnosestellung eine Ernährungsberatung erhalten (29,9 %).

Schlussfolgerung Etwa jeder dritte Patient mit einer Tumorerkrankung in ambulanter Betreuung weist ein erhöhtes Risiko für eine Mangelernährung auf. Die Ergebnisse dieser Erhebung unterstreichen die Notwendigkeit für ein systematisches Screening auf Mangelernährung und ein leitliniengerechtes Ernährungsmanagement von Tumorpatienten in der ambulanten Versorgung.
European Committee for Treatment and Research in Multiple Sclerosis
Authors: Anja Katharina
Published: December 2019

Die Jahrestagung des European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) ist mit mehr als 8000 Teilnehmern der weltweit größte jährlich stattfindende Kongress, der sich mit Grundlagen- und klinischer Forschung im Bereich der Multiplen Sklerose (MS) befasst. Das Wissen über MS und ihrer Behandlung ist in den vergangenen Jahren auch im pädiatrischen Bereich rapide gewachsen, aber es gibt noch viele offene Fragen, die im September in Stockholm diskutiert wurden.
Perspektive einer PrEP-Nutzerin auf die PrEP
Authors: Sweers Holger
Published: December 2019

Miriam (Pseudonym) ist zum Zeitpunkt des Interviews im Herbst 2018 35 Jahre alt. Sie lebt seit mehr als zehn Jahren in Berlin, wo sie auch studiert hat. Aktuell arbeitet sie als Marketingexpertin. Miriam führt ein aktives, selbstbestimmtes Sexualleben und greift aus guten Gründen zur HIV-PrEP, wie sie im Interview mit Holger Sweers erklärt.
How to identify patients who are less likely to have metachronous neoplasms after a colon cancer: a predictive model
Authors: Frazzoni Leonardo , Laterza Liboria , Mussetto Alessandro , Zagari Rocco Maurizio , Trovato Cristina , De Bellis Mario , Paggi Silvia , Piccirelli Stefania , Ricciardiello Luigi , Cesaro Paola , Spada Cristiano , Dal Piaz Giulia , La Marca Marina , Fabbian Fabio , Petrella Laura , Smania Veronica , Marone Pietro , Tatangelo Fabiana , Bazzoli Franco , Radaelli Franco , Repici Alessandro , Hassan Cesare , Scagliarini Michele , Fuccio Lorenzo
Published: December 2019

Background Patients with prior colon cancer have increased risk of metachronous colorectal neoplasms; therefore, endoscopic surveillance is indicated. Current recommendations are not risk-stratified. We investigated predictive factors for colorectal neoplasms to build a model to spare colonoscopies for low-risk patients.

Methods This was a multicenter, retrospective study including patients who underwent surgery for colon cancer in 2001 – 2008 (derivation cohort) and 2009 – 2013 (validation cohort). A predictive model for neoplasm occurrence at second surveillance colonoscopy was developed and validated.

Results 421 and 203 patients were included in derivation and validation cohort, respectively. At second surveillance colonoscopy, 112 (26.6 %) and 55 (27.1 %) patients had metachronous neoplasms in derivation and validation groups; three cancers were detected in the latter. History of left-sided colon cancer (OR 1.64, 95 %CI 1.02 – 2.64), ≥ 1 advanced adenoma at index colonoscopy (OR 1.90, 95 %CI 1.05 – 3.43), and ≥ 1 adenoma at first surveillance colonoscopy (OR 2.06, 95 %CI 1.29 – 3.27) were independently predictive of metachronous colorectal neoplasms at second surveillance colonoscopy. For patients without such risk factors, diagnostic accuracy parameters were: 89.3 % (95 %CI 82.0 %-94.3 %) and 78.2 % (95 %CI 65.0 %-88.2 %) sensitivity, and 28.5 % (95 %CI 23.5 %-33.9 %) and 33.8 % (95 %CI 26.2 %-42.0 %) specificity in derivation and validation group, respectively. No cancer would be missed.

Conclusions Patients with prior left-sided colon cancer or ≥ 1 advanced adenoma at index colonoscopy or ≥ 1 adenoma at first surveillance colonoscopy had a significantly higher risk of neoplasms at second surveillance colonoscopy; patients without such factors had much lower risk and could safely skip the second surveillance colonoscopy. A prospective, multicenter validation study is needed.
Psychische Komorbidität bei der juvenilen idiopathischen Arthritis
Authors: Sengler Claudia , Niewerth Martina , Holl Reinhard W. , Kilian Reinhold , Meissner Thomas , Staab Doris , Warschburger Petra , Baumeister Harald , Minden Kirsten
Published: December 2019

Psychische Erkrankungen wie Depression und Angst beginnen häufig im Jugend- und jungen Erwachsenenalter. Heranwachsende mit einer chronischen rheumatischen Erkrankung haben hierfür ein besonderes Risiko. In Untersuchungen zur psychischen Gesundheit gaben in der Regel über 10 % der Jugendlichen mit juveniler idiopathischer Arthritis (JIA) depressive Symptome an. Die frühzeitige Erkennung von psychischen Belastungen ist notwendig, um Betroffenen rechtzeitig adäquate Unterstützung anbieten zu können. Geschieht das nicht, werden Möglichkeiten, die Langzeitprognose und Lebensqualität der Betroffenen zu verbessern, verpasst. Psychische Störungen werden in der klinischen Praxis oft nur am Rande berücksichtigt. Wie groß das Problem unter den bundesweit kinder- und jugendrheumatologisch betreuten Patienten mit JIA ist, wird in diesem Jahr im Rahmen des interdisziplinären Forschungsverbundes COACH untersucht.
Limited diagnostic accuracy and clinical impact of single-operator peroral cholangioscopy for indeterminate biliary strictures
Authors: de Vries Adriaan B. , van der Heide Frans , ter Steege Rinze W. F. , Koornstra Jan Jacob , Buddingh Karel T. , Gouw Annette S. H. , Weersma Rinse K.
Published: December 2019

Background Single-operator peroral cholangioscopy (sPOCS) is considered a valuable diagnostic modality for indeterminate biliary strictures. Nevertheless, studies show large variation in its characteristics and measures of diagnostic accuracy. Our aim was to estimate the diagnostic accuracy of sPOCS visual assessment and targeted biopsies for indeterminate biliary strictures. Additional aims were: estimation of the clinical impact of sPOCS and comparison of diagnostic accuracy with brush cytology.

Methods A retrospective single-center study of adult patients who underwent sPOCS for indeterminate biliary strictures was performed. Diagnostic accuracy was defined as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The clinical impact of sPOCS was assessed by review of medical records, and classified according to its influence on patient management.

Results 80 patients were included, with 40 % having primary sclerosing cholangitis (PSC). Prior ERCP was performed in 88 %, with removal of a biliary stent prior to sPOCS in 55 %. The sensitivity, specificity, PPV, and NPV for sPOCS visual impression and targeted biopsies were 64 %, 62 %, 41 %, and 84 %, and 15 %, 65 %, 75 %, and 69 %, respectively. The clinical impact of sPOCS was limited; outcome changed management in 17 % of patients. Sequential brush cytology sensitivity, specificity, PPV, and NPV were 47 %, 95 %, 80 %, and 83 %.

Conclusions The diagnostic accuracy of sPOCS for indeterminate biliary strictures was found to be inferior to brush cytology, with a low impact on patient management. These findings are obtained from a select patient population with a high prevalence of PSC and plastic stents in situ prior to sPOCS.
Variables Correlated with Physical Activity and Conformance to
Physical Activity Guidelines in Healthy Children and Children with Down
Syndrome
Authors: Alhusaini Adel A. , Ali Al-Walah Misfer , Melam Ganeswara Rao , Buragadda Syamala
Published: December 2019

Ziel Kinder mit Down-Syndrom zeigen körperliche und geistige
Entwicklungsverzögerungen. Aus diesem Grund können sie
möglicherweise die Empfehlungen für Bewegung nicht
erfüllen. Hauptziel dieser Studie war es, das Maß der
körperlichen Aktivität und die Gehleistung von Kindern mit
Down-Syndrom zu beurteilen.

Material und Methoden Querschnittsstudie. Es wurden Kinder mit
Down-Syndrom und gesunde Kinder im Alter von 8 bis 12 Jahren untersucht. Die
körperliche Aktivität wurde über 7 Tage mittels
Pedometer gemessen und die Gehfähigkeit wurde mittels 6-Minuten Gehtest
(6MWT) bewertet.

Ergebnisse Kinder mit Down-Syndrom sind körperlich weniger aktiv
als gesunde Kinder. Der Test der durchschnittlichen Gehfähigkeit ergab
in allen Altersgruppen signifikante Unterschiede zwischen gesunden Kindern und
Kindern mit Down-Syndrom. Es bestand ein enger Zusammenhang zwischen der
täglichen Schrittzählung und der Gehfähigkeit.

Schlussfolgerung In unserer Studie konnten wir feststellen, dass Kinder
mit Down-Syndrom einen höheren BMI haben, weniger körperlich
aktiv sind und im Vergleich zu normal entwickelten Kindern eine geringere
Gehfähigkeit aufweisen.
Perspektive eines ehemaligen PrEP-Nutzers auf die PrEP
Authors: Döring Nicola
Published: December 2019

Steve Spencer war einer der ersten HIV-PrEP-Nutzer in Australien und Gründungsmitglied von PAN (PrEP Access Now), einer Non-Profit-Organisation, die sich für niedrigschwelligen Zugang zu PrEP in Australien einsetzt. Trotz PrEP-Einnahme hat er sich 2018 mit HIV infiziert. Denn die PrEP bietet zwar einen sehr hohen, aber eben keinen perfekten Schutz. Wovor er jetzt Angst hat und warum er sich immer noch für die PrEP stark macht, fasst Nicola Döring anhand seiner Pressebeiträge zusammen.
Aryl-Decarboxylation Reactions Catalyzed by Palladium: Scope and Mechanism
Authors: Daley Ryan A. , Topczewski Joseph J.
Published: December 2019

Palladium-catalyzed cross-couplings and related reactions have enabled many transformations essential to the synthesis of pharmaceuticals, agrochemicals, and organic materials. A related family of reactions that have received less attention are decarboxylative functionalization reactions. These reactions replace the preformed organometallic precursor (e.g., boronic acid or organostannane) with inexpensive and readily available carboxylic acids for many palladium-catalyzed reactions. This review focuses on catalyzed reactions where the elementary decarboxylation step is thought to occur at a palladium center. This review does not include decarboxylative reactions where decarboxylation is thought to be facilitated by a second metal (copper or silver) and is specifically limited to (hetero)arenecarboxylic acids. This review includes a discussion of oxidative Heck reactions, protodecarboxylation reactions, and cross-coupling reactions among others.

1 Introduction

2 Oxidative Heck Reactions

3 Protodecarboxylation Reactions

4 Cross-Coupling Reactions

5 Other Reactions

6 Conclusion
Artroplastia reversa de ombro: Resultados funcionais na artropatia do manguito
Authors: Nascimento Alexandre T. , Claudio Gustavo K. , Rocha Pedro B.
Published: December 2019

Objetivo Avaliar os resultados funcionais dos pacientes submetidos a artroplastia reversa de ombro, para tratamento da artropatia do manguito refratária a tratamento conservador.

Métodos Estudo retrospectivo de 20 pacientes (21 ombros), 17 mulheres (81%) e 3 homens (19%), submetidos a artroplastia reversa de ombro no período de outubro de 2012 a setembro de 2017, para tratamento de artropatia de manguito rotador, operados por um único cirurgião em um único centro. Os pacientes foram avaliados pelo escore de disfunções do braço, ombro e mão (DASH, na sigla em inglês), pelo questionário genérico de avaliação de qualidade de vida SF-36 (SF-36), pela escala visual analógica de dor (EVA) e pelo escore da Universidade de Los Angeles – Califórnia (UCLA, na sigla em inglês). A média de idade na cirurgia foi de 66 anos (variação de 55 a 83 anos). O tempo de sintomas antes da realização da cirurgia foi de ∼ 2,5 anos (variação de 12 meses a 6 anos). O seguimento médio foi de 42,4 meses (variação de 19 a 56,7 meses).

Resultados A média dos escores pós-operatórios foi de 18,2 pontos no DASH; de 2 pontos na EVA, sendo 16 (77%) de dores leves, 4 (18%) de dores moderadas e 1 (5%) de dor intensa; de 29 pontos no UCLA, sendo 6 pacientes com resultado regular (28%), 10 pacientes com resultado bom (48%), e 5 pacientes com resultado excelente (24%); e de 63 pontos no SF-36. Tivemos como complicações quatro casos de notching, um caso de fratura de acrômio por estresse, e um caso de infecção pós-operatória.

Conclusões A artroplastia reversa do ombro apresenta bons resultados funcionais nos escores avaliados, propiciando melhora significativa na qualidade de vida dos pacientes.