bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting the Mortality and Readmission of In-Hospital Cardiac Arrest Patients With Electronic Health Records: A Machine Learning Approach
Authors: Chi Chien-Yu , Ao Shuang , Winkler Adrian , Fu Kuan-Chun , Xu Jie , Ho Yi-Lwun , Huang Chien-Hua , Soltani Rohollah
Published: July 2021

Background

In-hospital cardiac arrest (IHCA) is associated with high mortality and health care costs in the recovery phase. Predicting adverse outcome events, including readmission, improves the chance for appropriate interventions and reduces health care costs. However, studies related to the early prediction of adverse events of IHCA survivors are rare. Therefore, we used a deep learning model for prediction in this study.

Objective

This study aimed to demonstrate that with the proper data set and learning strategies, we can predict the 30-day mortality and readmission of IHCA survivors based on their historical claims.

Methods

National Health Insurance Research Database claims data, including 168,693 patients who had experienced IHCA at least once and 1,569,478 clinical records, were obtained to generate a data set for outcome prediction. We predicted the 30-day mortality/readmission after each current record (ALL-mortality/ALL-readmission) and 30-day mortality/readmission after IHCA (cardiac arrest [CA]-mortality/CA-readmission). We developed a hierarchical vectorizer (HVec) deep learning model to extract patients’ information and predict mortality and readmission. To embed the textual medical concepts of the clinical records into our deep learning model, we used Text2Node to compute the distributed representations of all medical concept codes as a 128-dimensional vector. Along with the patient’s demographic information, our novel HVec model generated embedding vectors to hierarchically describe the health status at the record-level and patient-level. Multitask learning involving two main tasks and auxiliary tasks was proposed. As CA-mortality and CA-readmission were rare, person upsampling of patients with CA and weighting of CA records were used to improve prediction performance.

Results

With the multitask learning setting in the model learning process, we achieved an area under the receiver operating characteristic of 0.752 for CA-mortality, 0.711 for ALL-mortality, 0.852 for CA-readmission, and 0.889 for ALL-readmission. The area under the receiver operating characteristic was improved to 0.808 for CA-mortality and 0.862 for CA-readmission after solving the extremely imbalanced issue for CA-mortality/CA-readmission by upsampling and weighting.

Conclusions

This study demonstrated the potential of predicting future outcomes for IHCA survivors by machine learning. The results showed that our proposed approach could effectively alleviate data imbalance problems and train a better model for outcome prediction.
Role of Metacognitive Beliefs in the Prediction of Academic Procrastination: A Case Study of the Students of Kermanshah University of Medical Sciences, Iran (Preprint)
Authors: Safari Yahya
Published: July 2021

BACKGROUND

The present study aimed to determine the predictability level of academic procrastination based on students’ metacognitive beliefs at Kermanshah University of Medical Sciences (KUMS), Iran.

OBJECTIVE

Determine the predictability level of academic procrastination based on students’ metacognitive beliefs at Kermanshah University of Medices (KUMS), Iran.cal Scien

METHODS

Materials and Methods: This descriptive, cross-sectional study was performed on 300 students selected via stratified random sampling. Data were collected using PASS by Solomon and Rothblum (1984) and Mc0-30 by Wells and Cartwright-Hatton. Data analysis was carried out using Pearson’s correlation-coefficient and regression analysis.

RESULTS

Results: A negative significant correlation was observed between the subscale of positive beliefs of concern with academic procrastination (r=-0.16; P<0.05). In addition, the metacognitive beliefs of the participants predicted 10% of academic procrastination. The component of positive metacognitive beliefs with the beta value of -0.45 negatively and significantly predicted the students’ academic procrastination, whereas the component of negative metacognitive beliefs with the beta value of 0.42 positively and significantly predicted the students’ academic procrastination (P<0.05).

CONCLUSIONS

Conclusion: The obtained results had implications for the better understanding of academic procrastination and using academic interventions for its correction.
Osteointegration of polylactide-based implants
Authors: Makarov V.B. , Dedukh N.V. , Nikolchenko O.A.
Published: July 2021

Background. Materials degrading after implantation into bone are in the field of actual vision of orthopediс surgeon. These materials include polylactides, which are the ideal material for creating bone implants in 3D-printer, especially implants of complex shapes and different sizes. The purpose of the study is to conduct a comparative analysis of bone remodeling under conditions of implantation of polylactide 3D-printed screws into metadiaphyseal and diaphyseal defects of the rat femur. Materials and methods. Comparative analysis of bone remodeling under conditions of implantation of polylactide Ingeo™ Biopolymer 4032D 3D-printed screws into the metadiaphyseal and diaphyseal defects of the rat femur for 15, 30, 90, 180 and 270 days are conducted. After implantation of polylactide, areas of bone with implants were examined by the histological method with the determination of the osteointegration index. Results. It was found that for all the study periods the implants kept their shape, were surrounded by bone tissue. The osseointegration index on the 270th day in metadiaphyseal and diaphyseal defects is 97.1 and 94.3 %, respectively, and is statistically higher compared to the 15th day by 2.2 and 2.3 times (p < 0.001). Conclusions. The polylactide-based Ingeo™ Biopolymer 4032D implants are biocompatible, have high osteointegration qualities, do not cause inflammation in the surrounding soft tissues and bone marrow, do not lead to destructive changes of the bone in the implantation sites. At the end of the study (270 days), the degradation of polylactide is not found, which makes it possible to use it for fixation or filling cavities in compact and spongy bones for a long time.
Kolaborasi Komunitas Stucash dan Lakoni dalam Penanganan Dampak Sosial-Ekonomi Pandemi COVID-19
Authors: Miftah Awalurrizqi  , Sumantiyasmi Agresti Retno , Azzahidah Atikah
Published: July 2021

Komunitas Stucash dan Lakoni menjadi aktor penting dalam penanganan pandemi COVID-19 di Yogyakarta karena bersentuhan secara langsung dengan masyarakat dan juga telah akrab dengan pemanfaatan teknologi digital. Penelitian ini bertujuan untuk melihat bagaimana kolaborasi dua komunitas tersebut dalam penanggulangan dampak sosial-ekonomi akibat pandemi. Komunitas Stucash dan Lakoni dipilih sebagai fokus penelitian karena mereka merupakan representasi dari pergerakan sosial oleh pemuda, mulai dari tahap inisiasi, konsepsi hingga eksekusi. Penelitian ini merupakan jenis penelitian kualitatif-deskriptif dengan teknik pengumpulan data melalui wawancara secara daring terhadap perwakilan dari setiap komunitas, dokumentasi dan observasi pada publikasi serta interaksi dari akun media sosial di tiap komunitas. Hasil dari penelitian menunjukkan bahwa Stucash dan Lakoni mampu membantu kinerja Pemerintah Daerah D.I. Yogyakarta dalam menanggulangi dampak sosial-ekonomi akibat pandemi COVID-19 dengan menggunakan pendekatan partisipatif dimana komunitas sebagai wujud aktor dari masyarakat menjadi inisiator utama sekaligus eksekutor gerakan dengan memanfaatkan teknologi digital yang dalam hal ini yaitu media sosial.

Kata Kunci: Kolaborasi, Komunitas Pemuda, Media Baru, Pandemi COVID-19 

 

The Stucash and Lakoni communities are important actors in handling the COVID-19 pandemic in Yogyakarta because they have direct contact with the community and familiar with the utilization of digital technology. This study aims to see how the collaboration of the two communities in dealing with the socio-economic impacts of the pandemic is. The Stucash and Lakoni communities were chosen as the research focus because they represent the social movements of youth from initiation, conception to execution stages. This research is a descriptive-qualitative type with data collection techniques through online interviews to representatives from each community, documentation and observation on publications and interactions in social media accounts of each community. The results of the study show that Stucash and Lakoni are able to help the performance of the local government of D.I. Yogyakarta in overcoming the socio-economic impacts of the COVID-19 pandemic by using a participatory approach in which the community as an actor from society becomes the main initiator and executor of the movement by utilizing digital technology, which in this context is social media.

Keywords: Collaboration, COVID-19 Pandemic, New Media, Youth Communities
Slavery Beyond History: Contemporary Concepts of Slavery and Slave Redemption in Ganta (Gamo) of Southern Ethiopia
Authors: Bombe Bosha
Published: July 2021

Slavery was officially abolished in Ethiopia by Emperor Haile Sellassie in 1942. Despite the abolitionary law slaves and their descendants have continually been marginalized in the country (especially in the peripheral parts of southwestern Ethiopia) from the time the law passed until today. In the Gamo community of southern Ethiopia, descendants of former slaves carry the identity of their ancestors and as the result they are often harshly excluded. Today, not only are they considered impure, but their perceived impurity is believed to be contagious; communicable to non-slave descendants during rites of passage. In order to escape the severe discrimination, slave descendants change their identity by redeeming themselves through indigenous ritual mechanism called wozzo ritual. However, the wozzo ritual builds the economy of former slave masters and ritual experts while leaving redeemed slave descendants economically damaged. This study is both diachronic and synchronic; it looks at the history of slavery, contemporary perspectives and practices of slavery and slave redemption in Ganta (Gamo) society of southern Ethiopia.
Adopting an Anti-human Trafficking Law in the DR Congo: A Significant Step in the Process of Combating Trafficking
Authors: Liwanga Roger-Claude
Published: July 2021

This paper highlights the necessity of adopting a comprehensive anti-human trafficking law in the Democratic Republic of Congo (DRC). The DRC ratified a number of international instruments prohibiting human trafficking, such as the Palermo Protocol, which recommend it to take legislative measures against human trafficking domestically. But so far, the DRC has not yet adopted a comprehensive anti-human trafficking law. With the increasing prevalence of human trafficking, the existing fragmented provisions on trafficking in the DRC (catalogued within the Law 06/018 amending the Penal Code, the Labor Code and the Law 09/001 on the Protection of the Child) are not sufficient to address the scourge, given the limited scope of their regulation of human trafficking. Countless victims of trafficking, particularly adults who are subjected to bonded labor, are unprotected by the law. Following the example of comprehensive anti-human trafficking legislations in the United States, Italy, Burkina Faso, Kenya or South Africa, the DRC should also adopt its own version of comprehensive anti-human trafficking law to increase its likelihood of effectively protecting trafficking victims, investigating trafficking offences, prosecuting trafficking offenders, and deterring potential traffickers. This paper recommends a sketch of a holistic anti-human trafficking law which is adapted to the DRC’s context.
NF-kB decoy oligodeoxynucleotide preserves disc height in a rabbit anular-puncture model and reduces pain induction in a rat xenograft-radiculopathy model
Authors:   Department of Orthopedic Surgery, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Kato K , Akeda K , Miyazaki S , Yamada J , Muehleman C , Miyamoto K , Asanuma YA , Asanuma K , Fujiwara T , Lenz ME , Nakazawa T , An H , Masuda K
Published: July 2021

While it is known that the degenerated intervertebral disc (IVD) is one of the primary reasons for low-back pain and subsequent need for medical care, there are currently no established effective methods for direct treatment. Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes’ expression, among which are inflammatory cytokines, in many tissues including the IVD. NF-κB decoy is an oligodeoxynucleotide containing the NF-κB binding site that entraps NF-κB subunits, resulting in suppression of NF-κB activity. In the present preclinical study, NF-κB decoy was injected into degenerated IVDs using the rabbit anular-puncture model. In terms of distribution, NF-κB decoy persisted in the IVDs up to at least 4 weeks after injection. The remaining amount of NF-κB decoy indicated that it fit a double-exponential-decay equation. Investigation of puncture-caused degeneration of IVDs showed that NF-κB decoy injection recovered, dose-dependently, the reduced disc height that was associated with reparative cell cloning and morphological changes, as assessed through histology. Gene expression, by quantitative real-time polymerase chain reaction (qRT-PCR), showed that NF-κB decoy attenuated inflammatory gene expression, such as that of interleukin-1 and tumor necrosis factor-α, in rabbit degenerated IVDs. NF-κB decoy also reduced the pain response as seen using the “pain sensor” nude rat xenograft-radiculopathy model. This is the first report demonstrating that NF-κB decoy suppresses the inflammatory response in degenerated IVDs and restores IVD disc height loss. Therefore, the intradiscal injection of NF-κB decoy may have the potential as an effective therapeutic strategy for discogenic pain associated with degenerated IVDs.
The numerical parametric study of the stress-strain state of I-beams having versatile corrugated webs
Authors: Saiyan Sergey G. , Paushkin Alexander G.
Published: July 2021

Introduction. The numerical parametric study of the stress-strain state of I-beams, having versatile corrugated walls, was carried out in the ANSYS Mechanical APDL software package. Numerical results are obtained for displacements, equivalent stresses and stability coefficients depending on the change in the inclination angle of web corrugations for trapezoidal, wavy and triangular profiles. The obtained results can help to design and substantiate the design solutions applicable to bending elements.

Materials and methods. The parametric study involved a series of numerical experiments conducted using the finite element method in the ANSYS Mechanical APDL software package. APDL parametric language was used to develop the software that was built into the software package. It allowed to perform a parametric reconstruction of the numerical model depending on varied parameters of the corrugated wall, and the reconstruction was followed by the numerical solution and post-processing of the calculation results. The calculations were made with the help of the model whose overall dimensions and material were identical to those of a standard I-beam having a solid wall exposed to a uniformly distributed transverse load.

Results. The parametric study enabled the co-authors to identify the main features of the stress-strain state of the beams that had different types of corrugated walls. A parametric numerical model was compiled to determine maximum displacements, equivalent stresses and stability coefficients for various types of corrugated walls and various parameters of the corrugation angle. Isofields of equivalent stresses and buckling modes are provided for characteristic parameters and types of corrugations. The reliability of the obtained results was confirmed by the verification of the numerical model using the method of the strength of materials and corrugation inclination angle α = 0, which was the initial point of simulation for all types of corrugations.

Conclusions. The results, obtained in the course of parametric studies, have identified the main features of the stress-strain state of beams having corrugated walls; they allow to substantiate their effectiveness as design solutions applied to bending elements.
Multifunctional layered composite material used for construction purposes
Authors: Gumeniuk Alexander N. , Polyanskikh Irina S. , Petrunin Semen M. , Shevchenko Filipp E. , Pervushin Grigory N.
Published: July 2021

Introduction. The adjustability of electrical properties of materials, that have hydraulic setting characteristics, has been studied over the last decades. It is emphasized that any change in electrical properties, triggered by various additives, causes negative side effects, including low corrosive resistance and modified physical and mechanical characteristics. The purpose of this research is to design a multifunctional layered material that features localized electrical conductivity. The objective is to track the influence of modifiers, capable of regulating electrical properties.

Materials and methods. Samples were made of Portland cement I 42.5; the cement, having the fineness modulus of 0.7, was used as the aggregate; samples also contained ground Sulphur type 9998 (GOST 127.1-93), soot slurry, and calcium nitrate. The co-authors have identified the unit resistance values of each layer of this composite material, mechanical properties and features of each layer, and the structure of contact layers.

Results. The co-authors have determined that the addition of pre-treated Sulphur in the amount of 7 % of the binder mass facilitates the formation of a nonconductive layer, whose unit resistance reaches 29.57 kiloohm cm on the 28th day. The conductive layer, generated by adding soot in the amount of 7 % of the binder mass, ensures the stable passage of electric current. The co-authors have identified that calcium nitrate influences the morphology of secondary crystalline hydrates and the non-crystalline phase of the mineral matrix, made of Portland cement, and it also ensures the required concrete strength.

Conclusions. The layered method of formation of new compositions allows to make composite materials having adjustable electrical characteristics. New materials are made of Portland cement, and they contain no non-conductors. The co-authors have proven the efficiency of Sulphur, an integrated modifier made of soot and calcium nitrite, used as the modifiers of the mineral matrix, since they regulate the electrical properties of the artificial stone.
A change model of the hydraulic characteristics of the territory occupied by the landfill of solid industrial and domestic waste
Authors: Kovrigin Artur A. , Slesarev Mikhail Yu.
Published: July 2021

Introduction. A landfill of solid industrial and domestic waste (LSIDW) is a source of negative impact on the environment. Although landfills have coverings, and they are equipped with engineering systems designated for the capturing and treatment of the biogas, LSIDW landfills still have a negative impact on subsurface and surface waters due to the spread of leachate. The purpose of this work is to obtain predictive data on changes in the hydrogeological characteristics of the territory of Salaryevo landfill, and to develop a simulation model to assess the application of technical solutions in the course of the landfill reclamation.

Materials and methods. Processing Modflow is the software designated for the 3D modeling of filtration and transportation of pollutants. An engineering report based on the engineering and environmental surveys, performed by JSC MosvodokanalNIIproekt in the Salaryevo landfill and its environs in 2017, served as the input data designated for a simulation model.

Results. Processing Modflow software allowed to consider three options of cutoff walls, tailored to this landfill. The installation of cutoff walls on the east and west sides of the landfill, to be performed with regard for the sorption function of the cutoff walls, is the most effective solution. The results have shown that the cutoff walls, installed to prevent the leachate from seeping, can potentially reduce the area, exposed to the impact, by 500 m.

Conclusions. It is recommended to install a cutoff wall in the west and a sorption curtain in the east in the course of recultivating Salaryevo landfill; this solution will ensure the containment of the leachate inside the landfill and prevent its spreading.
A Review of Recent Korean Medicine Treatment for Chronic Subdural Hematoma Using the CNKI Database
Authors: Je Yu-ran , Kim Kyong-lim , Hwang Won-deok
Published: July 2021

Objectives: This study investigates the latest clinical studies on Korean medicine treatment of chronic subdural hematoma (CSDH) in China.Methods: A CNKI search investigated the last 10 years of clinical studies of Korean medicine treatments in Chinese medical journals for CSDH. The search focused on authors, publication years, types of studies, purposes of studies, methods and duration of treatment, evaluation criteria, and results of treatment.Results: In 19 studies, there were 14 randomized controlled trials (RCTs), 4 case series, and 1 case-control study. In all 19 studies, Korean medical treatment and Western treatment were combined. Herbal medicine was used in 19 studies and acupuncture treatment in 2 studies. The most frequently used prescription was Hyeolbuchukeo-tang-gagambang, and the most frequently used acupoint was PC6. In all 19 studies, the effectiveness of Korean medicine treatment performed in parallel with Western treatment was confirmed.Conclusions: In this study, Korean medicine combined with Western treatment for CSDH was effective. More clinical studies and case reports are required to develop a guided treatment for CSDH.
Effects of Korean Medicine in Idiopathic Pulmonary Fibrosis Patients - A Retrospective Chart Review
Authors: Hong Sung-eun , Kang Sung-woo , Park Ji-won , Jang Kwon-jun , Park Su-hyeon , Kim Kwan-il , Bu Yung-min , Jung Hee-jae , Lee Beom-joon
Published: July 2021

Objective: This study was designed to analyze the clinical features of idiopathic pulmonary fibrosis patients who attended a Korean medicine hospital and the treatment effects through retrospective chart reviews.Methods: The medical records of 82 outpatients who had been diagnosed with idiopathic pulmonary fibrosis and visited the Allergy, Immune, and Respiratory System Department of Kyung Hee Korean Medicine Hospital from 8 January 2015 to 8 January 2021 were retrospectively reviewed. To assess the treatment outcomes, we used the FVC (Forced Vital Capacity), DLCO (Diffusing capacity of the Lung for CO), 6-minute walk test, and HRCT (High Resolution Computed Tomography).Results: The study group consisted of 28 females and 54 males. The median age of the patients was 67.98±11.44 years. The chief complaints were cough (n=51) and dyspnea (n=49). Other frequent symptoms were general weakness (n=8), weight loss (n=4), and a fever (n=2). A total of 77 (93.90%) patients were prescribed Korean herbal medicine, and 52 (63.41%) patients were treated with acupuncture, moxibustion, cupping therapy, ICT, or pharmacopuncture. After treatments, FVC, DLCO, the 6-minute walk test, and HRCT were maintained or worsened slightly.Conclusions: This study presented the characteristics of idiopathic pulmonary fibrosis patients treated by Korean medical therapies, and further studies of Korean medical treatments for idiopathic pulmonary fibrosis patients would be valuable.
A Case of the Therapeutic Effect of Nangan-jeon on Refractory Functional Dyspepsia Caused by “Liver-Kidney Deficiency Cold”
Authors: Son Chang-gue
Published: July 2021

Objective: This study explored the clinical usefulness of Nangan-jeon decoction to treat refractory functional dyspepsia.Methods: A 61-year-old female had been suffering from severe functional dyspepsia for about 40 years, but the dyspeptic symptoms rapidly improved after taking Nangan-jeon decoction. The clinical outcome was assessed by the numerical rating scale (NRS) and the self-reporting method.Result: After there was no improvement from various herbal treatments in a department of a Korean college hospital, the patient moved to the author’s clinic. She had been diagnosed with the pattern identification of “liver-kidney deficiency cold” and prescribed with Nangan-jeon decoction. This herbal drug rapidly improved her dyspeptic symptoms, from NRS 10 to NRS 2 (after 3 weeks) and NRS 1 (after 7 weeks).Conclusion: This case report is the first to present the potential of Nangan-jeon decoction to improve refractory functional dyspepsia.
Orodispersible Tablet in Treatment of Migraine: Opportunities, Challenges and Recent Advancements
Authors: Bhattacharya Suhasis , Mohanta Tanmay , Das Sujit , Basak Rumpa
Published: July 2021

The most comfortable and choicely path of drug administration is oral route. Orodispersible tablets bring a revolution among all routes of drug administration as well as oral route of drug administration also. Orodispersible tablets are unit dosage form but it has unique characteristics. It disintegrates in the mouth within a minute for the presence of saliva where the presence of super disintegrates in the preparation. Especially, old and child have no chance to swallow as a result it is very acceptable for them. Migraine is a very well-known irritating condition for adult and female. Migraine is a debilitating and common neurovascular illness associated with symptoms of one-sided headache, nausea with or without vomiting, photophobia and/or phonophobia. But these symptoms are subjective and vary from patient to patient. Orodispersible tablets are most important solution of migraine like emergency condition and helping human by transferring from hell to heaven. Very short half-life, quick disintegration, quick onset of action and better bioavailability brings the orodispersible tablets into the top position of the management of migraine. Sumatriptan, zolmitriptan like drugs are helping their hands to reduce migraine. Lastly, there are lots of drugs are investigating for this purpose and our hope that the orodispersible tablet can give the pioneer and will give the migraine free era to us and our futures.

Keywords: Orodispersible tablet, migraine, sumatriptan, super disintegrate, fast dissolving
“Organs on a Chip”: Revolutionization in personalized treatment
Authors: Sahoo Subhalaxmi , Patel Priyanka , Goswami Meghna
Published: July 2021

“Organs-on-a-chip” (OOAC), involves microfluidics based biomaterial sciences, bio-engineering and cell biology majorly cell isolation and cell culturing aspects. This technology claims to develop 3-dimensional tissues structurally and physiologically in simulation to in vivo providing relevant results in terms of physiological and genetic aspects with virtue of its origin from human systems. In recent times, experts from diversified disciplines have developed and established many OOAC systems with an assertion of being perfect for drug research replacing convectional cell cultures and animal testing due to the technical limitations in the applicability  of the same in vivo for systemic complexities and genetic variances. “Organs-on-a-chip” has attracted substantial interest for its wide range of applications in fields of drug research, regenerative medicine and personalized medicine. Successful development and establishments of different OOACs will contribute towards newer avenues in the path of precised personalized medicine. 

Keywords: Organs on a chip, personalized medicine, OOAC, 3D cell culture
Pharmacognostical and Physiochemical Study on the Leaves of Nyctanthes arbor-tristis Linn
Authors: Bijauliya Rohit Kumar , Kannojia Pushpendra , Mishra Pankaj , Singh Prashant Kumar , Kannaujia Rahul
Published: July 2021

Aim: To rationalize the macroscopial, microscopical and physico-chemical studies on leaves of plant Nyctanthes arbor-tristis Linn. Methods: The pharmacognostic characters were determined in terms of macroscopy, microscopy and powder microscopy of plant Nyctanthes arbor-tristis leaves. The crude ethanolic extract of leaves of Nyctanthes arbor-tristis Linn. was using physico-chemical parameters, and preliminary phytochemical investigation (TLC). Results: The microscopic study shows the general characteristic of Nyctanthes arbor-tristis leaves. Phytochemical analysis revealed the presence of various phytochemical groups like alkaloids, glycosides, steroids, phenolic, tannins constituents. Conclusion: It can be concluded that the established pharmacognostic profile of Nyctanthes arbor-tristis leaves will be helpful in developing pharmacopoeial standards for correct identification and quality control. The present observation will also be helpful in macroscopical and microscopical on leaves of Nyctanthes arbor-tristis Linn.

Keywords: Nyctanthes arbor-tristis, Pharmacognostical Study, Macroscopial and Microscopical studies
Integration of Complementary and Alternative Medicines in Health care system to combat COVID 19- A Validation
Authors: Shinde Vaishali H. , Bawaskar Ramesh
Published: July 2021

Human mankind has always been under the wrath of various epidemics viz. Spanish Flu, Asian Flu, Hong Kong Flu, influenza A-H1N1 virus, SARS in 2003, etc. The on-going COVID 19 pandemic has posed as a serious concern to humans with no proper treatment and no specific drugs against this virus. There have been various challenges to the current health care delivery system. There is dearth of reported RCTs evaluating effects of antivirals. Corticosteroid treatment has reported to have delayed coronavirus RNA clearance with its widespread use leading to development/exacerbation of fungal diseases like Mucormycosis. Various vaccines designed have many questions about their efficacy that may rise with time, as SARS-CoV-2 has numerous variants, and it can mutate over time. With limited success in developing antivirals, Complementary and Alternative medicines like Traditional Chinese medicines, Ayurvedic and homoeopathic medicines have been gaining momentums in recent years displaying promising results. Methodical researches are warranted to further evaluate the efficacy of Complementary and alternative medicines. For curtailing the devastating effects of COVID 19 requires reviewing the current health policies by integrating complementary medicine with conventional system. To channelize all the available therapeutic options to win the battle against COVID-19 is the need of hour.
Evaluation of Anthelmintic Activity of Calendula officinalis Flowers Extract
Authors: Bhardwaj Alok , Alam Khursheed , Pathak Devender , Ansari Shahid , Sethi Vandana Arora
Published: July 2021

Background: The present study is an attempt to explore the anthelmintic activity of ethanolic extract of flower of Calendula officinalis. Various doses of ethanolic extracts were evaluated for their anthelmintic activity on adult Indian earthworms, Pheretima posthuma. Calendula officinalis Linn has been widely used in homeopathic medicine for the treatment of many diseases. It has been reported to possess many pharmacological activities, which include antibacterial, antifungal, antiviral,antioxidant and anti-inflammatory.

Methods: The ethanol extract of air dried flowers powder (500g) was prepared by using soxlet apparatus, concentrated and vacuum dried which gave an orange yellowish mass (60.46 g). Extract was subjected to qualitative chemical investigation of phytoconstituents such as glycosides, alkaloids, flavonoids, carbohydrates, tannins, proteins, vitamins, coumarins etc.

Results: All extracts were able to show anthelmintic activity at 10mg/mL concentration. The activities are comparable with the standard drugs, piperazine citrate and albendazole. The data were found statistically significantly by using one way Anova at 5% level of significance (p< 0.05).

Conclusion: All the doses of ethanolic extract of calendula officinalis showed dose dependent anthelmintic activity in comparison to standard drugs.

Keywords: Calendula officinalis, Asteraceae, Anthelmintic, Piperazine citrate, Albendazole
UTILIZAÇÃO DE INDICADORES DE LITERACIA EM SAÚDE SOBRE PROCEDIMENTOS E ATITUDES DE ADOLESCENTES EM EDUCAÇÃO SEXUAL
Authors: Zompero Andreia Freitas , Machado Gessica Aparecida , Santos Fabiana Moreira , Junior da Sila Marcos Henrique
Published: July 2021

As infecções sexualmente transmissíveis e os casos de gravidez precoce têm causado preocupação para os órgãos de saúde em todo mundo.  Segundo a Organização Mundial de Saúde a cada dia, há mais de 1 milhão de novos casos de infecções sexualmente transmissíveis  em pessoas de 15 a 49 anos, chegando a mais de 376 milhões de novos casos anuais. Em relação ao HIV/AIDS, no Brasil, em 2018, foram diagnosticados 43.941 novos casos de HIV e 37.161 casos de AIDS – notificados no Sinan. Nos casos de gravidez na adolescência o número é de 400 mil por ano no Brasil. No mundo, são aproximadamente 16 milhões na faixa etária de 15 a 19 anos; e 2 milhões menores de 15 anos. Nesse sentido é necessário conhecer as ações dos adolescentes mediante práticas de prevenção. O objetivo deste estudo foi identificar procedimentos e atitudes de adolescentes quanto à prevenção de IST e gravidez não planejada com base na manifestação de indicadores de literacia em saúde utilizando abordagem quanti e qualitativa. Participaram do estudo 99 alunos do nonos anos de uma escola pública do município de Londrina, que já haviam tido aulas sobre essa temática nas aulas de Ciências e também por meio de oficinas pedagógicas realizadas por alunos do curso de Enfermagem de uma instituição particular da cidade. Os alunos responderam a oito perguntas extraídas do instrumento National Health Education Standards Developing an “Exit Competencies” Assessment Instrument (2004). As respostasforam analisadas com base em indicadores propostos no mesmo instrumento: aquisição da informação, estratégias para implementação e planejamento de procedimentos relacionados a estratégias em saúde. Os resultados indicam que os alunos apresentaram resultados satisfatórios quanto à negociação do uso do preservativo, atitudes frente à gravidez não planejada e quanto aos recursos disponíveis nas unidades de saúde, mas foram insatisfatório quanto à prevenção de IST.
HOMEM ARANHA EM SALA DE AULA: PROPOSTA DO USO DE HISTÓRIAS EM QUADRINHOS E DA FICÇÃO CIENTÍFICA PARA O ENSINO DE CIÊNCIAS
Authors: Ornellas Janaína Farias de , Melo Letícia Gomes de
Published: July 2021

Considerando que documentos oficiais da educação básica argumentam a favor de trabalhar diferentes tipos de linguagens para o desenvolvimento da escrita, da leitura, do debate de questões filosóficas e aprimorar o domínio da contextualização sociocultural, o referido trabalho sugere o uso da aproximação entre dois campos do conhecimento que envolvem diferentes gêneros de linguagem: a literatura de ficção científica (FC) e a ciência por meio de História em Quadrinhos (HQ) para ensinar ciências. A proposta parte de HQs e da FC a fim de compreender os superpoderes dos heróis (considerados elementos contrafactuais aqueles elementos fora do comum ao mundo real, capazes de causar estranheza em sua leitura) sob a luz da Ciência e, com isso, se apropriar das diferentes linguagens que sugerem os documentos oficiais. Importante salientar que ao destacar os elementos contrafactuais, não significa que estaremos atribuindo alguma base Científica a esses elementos. O intuito é destacá-los e a partir disso, compreender e interpretar o discurso científico. Almejamos com isso que os estudantes por meio da literatura de FC tenham contato com discurso científico que sustentam as narrativas/histórias dos heróis, de forma dinâmica e interativa com a finalidade de promover o ensino dos conceitos/fenômenos científicos. Em igual medida, acreditamos que essa proposta pode auxiliar e fomentar ideias para os docentes sobre o uso da HQ em sala aula de forma diferente do que vem sendo proposto na literatura.
High density mapping of atrial insertion of retrograde decremental accessory pathway 3D-illustration of accessory atrio-ventricular conduction network
Authors: Maury Philippe , Voglimacci Quentin , Mandel Franck , Parlier Pauline , Tabuteau Maud , Beneyto Maxime , Rollin Anne
Published: July 2021

We report the case of a reciprocating tachycardia using a purely
retrograde decremental slow-conducting accessory pathway. High density
3D mapping of the atrial insertion reveals a large area of specific
potentials at the level of the tricuspid annulus, which can be regarded
as an accessory conduction network
An Enhanced Hidden Semi-Markov model for Outlier Detection in Multivariate Datasets
Authors: Manoharan G , Sivakumar K
Published: July 2021

Outlier detection in data mining is an important arena where detection
models are developed to discover the objects that do not confirm the
expected behavior. The generation of huge data in real time applications
makes the outlier detection process into more crucial and challenging.
Traditional detection techniques based on mean and covariance are not
suitable to handle large amount of data and the results are affected by
outliers. So it is essential to develop an efficient outlier detection
model to detect outliers in the large dataset. The objective of this
research work is to develop an efficient outlier detection model for
multivariate data employing the enhanced Hidden Semi-Markov Model
(HSMM). It is an extension of conventional Hidden Markov Model (HMM)
where the proposed model allows arbitrary time distribution in its
states to detect outliers. Experimental results demonstrate the better
performance of proposed model in terms of detection accuracy, detection
rate. Compared to conventional Hidden Markov Model based outlier
detection the detection accuracy of proposed model is obtained as
98.62% which is significantly better for large multivariate datasets.
Glutamine deficiency shifts the asthmatic state toward neutrophilic airway inflammation
Authors: Kim June-Mo , Im Yoo-Na , Chung Yun-Jo , Youm Jung-ho , Im Suhn-Young , Han Myung Kwan , Lee Hern Ku
Published: July 2021

Background: The administration of L-glutamine (Gln) suppresses
allergic airway inflammation via the rapid upregulation of MAPK
phosphatase (MKP)-1, which functions as a negative regulator of
inflammation by deactivating p38 and JNK mitogen-activated protein
kinases (MAPKs). However, the role of endogenous Gln remains to be
elucidated. Therefore, we investigated the mechanism by which endogenous
Gln regulates MKP-1 induction and allergic airway inflammation in an
ovalbumin-based murine asthma model. Methods: We depleted
endogenous Gln levels using l-γ-glutamyl- p-nitroanilide (GPNA),
an inhibitor of the Gln transporter ASCT2, and glutamine synthetase
small interfering (si)RNA. Lentivirus expressing MKP-1 was injected to
achieve overexpression of MKP-1. Asthmatic phenotypes were assessed
using our previously developed ovalbumin-based murine model, which is
suitable for examining sequential asthmatic events, including neutrophil
infiltration. Gln levels were analyzed using a Gln assay kit.
Results: GPNA or glutamine synthetase siRNA successfully
depleted endogenous Gln levels. Importantly, homeostatic MKP-1 induction
did not occur at all, which resulted in prolonged p38 MAPK and cytosolic
phospholipase A (cPLA )
phosphorylation in Gln-deficient mice. Gln deficiency augmented all
examined asthmatic reactions, but it exhibited a strong bias toward
increasing the neutrophil count, which was not observed in
MKP-1-overexpressing lungs. This neutrophilia was inhibited by a cPLA
inhibitor and a leukotriene B4 inhibitor, but not by
dexamethasone. Conclusion: Gln deficiency leads to the
impairment of MKP-1 induction and activation of p38 MAPK and cPLA
, resulting in the augmentation of neutrophilic, more
so than eosinophilic, airway inflammation.
Identity Ambiguity and Change in the Wake of a Corporate Spin-off
Authors: Corley Kevin G. , Gioia Dennis A.
Published: July 2021

We report on the findings of an inductive, interpretive case study of organizational identity change in the spin-off of a Fortune 100 company's top-performing organizational unit into an independent organization. We examined the processes by which the labels and meanings associated with the organization's identity underwent changes during and after the spin-off, as well as how the organization responded to these changes. The emergent model of identity change revolved around a collective state of identity ambiguity, the details of which provide insight into processes whereby organizational identity change can occur. Additionally, our findings revealed previously unreported aspects of organizational change, including organization members' collective experience of “change overload” and the presence of temporal identity discrepancies in the emergence of the identity ambiguity.
Managers' Mobility and Market Interface: The Effect of Managers' Career Mobility on the Dissolution of Market Ties
Authors: Broschak Joseph P.
Published: July 2021

Using social embeddedness arguments, this study examines how the mobility of managers in professional service and client firms affects dissolution among their firms' market ties for that service. My analyses from a sample of agencies and clients in the advertising industry from 1986 to 1998 show that the exit of managers from client firms increases the likelihood that market ties dissolve and that the results are contingent on the size of the firm. In professional service firms, both the exit and promotion of managers affect the number of market tie dissolutions, but these results are contingent on managers' functional roles and the number of market ties maintained by professional service firms. Taken together these findings illustrate how dynamics in managerial labor markets affect market ties for services and how firms' characteristics moderate these effects. The results suggest several refinements to the social embeddedness perspective. *
Partisipasi Kelompok Wanita Tani Dalam Meningkatkan Kawasan Rumah Pangan Lestari Di Nagari Sago Salido Kebupaten Pesisir Selatan
Authors: Putry Rahayu Erita , Dt.Maani Karjuni
Published: July 2021

Meeting the needs of food for the community in connection with increasing population and decreasing the number of agricultural areas. resulting in serious problems because the amount of food available is deficient. Based on this, a strategy that needs to be followed up to overcome the food crisis going forward. One of the efforts carried out by the government so far is to optimize the use of community houses as a source of family food. Food is a basic need for human survival, so everyone needs to be guaranteed to get quality and safe food. Food that is not produced properly and can be a source of microorganisms and chemical contaminants that can be dangerous and cause disease to humans. Cases of food poisoning should not need to occur if food products are processed with the correct processing procedures (Badan POM, 2007). Conditions for the fulfillment of food for the state up to individuals, as reflected in the availability of sufficient food, both in quantity and quality, safe, diverse, nutritious, equitable and affordable and not contrary to religion, beliefs, and culture of the community, to be able to live healthy, active, and productive in a sustainable manner (Law No. 18/2012).
Implementasi Kebijakan Ketahanan Pangan Dalam Meningkatkan Kesejahteraan Masyarakat di Kabupaten Pesisir Selatan (studi kasus pengelolaan cadangan pangan pemerintahan desamelalui kelembagaan lumbung pangan)
Authors: Rahmi Hasanatul , Jumiati Jumiati
Published: July 2021

The purpose of this study is to find out the implementation of food security policies to improve welfare through food reserve management programs. The aim is to increase the volume of group food reserves to ensure access and adequate food for its members and increase group capital through productive economic endeavors. This study uses qualitative research with a normative-empirical and phenomenal approach. The informants in this study were determined by purposive sampling with a total of 6 people, namely the Head of Planning, the Head of Food Security, the Mayor of Nagari and the Communitys. The data used are primary data and secondary data, derived from field observations or observations, interviews and documentation studies. This data is tested for validity using source triangulation techniques which are then analyzed with qualitative data analysis techniques. The results showed that the process of implementing food security policy in its implementation still needed some improvements such as in terms of resources involved, characteristics of the ruling institutions and responses from implementers. Supporting factors in the implementation of food security policies are built by the government food storage (granary) which is built by the special allocation fund (DAK) in agriculture and is given a budget in replenishing community food reserves. Whereas the saving factor is the lack of community understanding of how the system in managing community food reserves which causes internal problems in groups such as people who borrow grain / rice in storage (granaries) do not return loans according to the agreement. Efforts made by the Department of Food directly met with members of the group to request that loans be returned in accordance with the agreement that had been made so that the stock of community food reserves could still be available in storage areas (granaries).
peningkatan mutu pendidikan Peningkatan Mutu Pendidikan di Sekolah Dasar (SD)
Authors: Atikah Nur , Resisca Yeni
Published: July 2021

Artikel ini bertujuan untuk menentukan mutu pendidikan di sekolah dasar. Artikel ini memberikan kontribusi kepada kepala sekolah dalam meningkatkan supervisi agar kinerja sekolah dasar sangat baik. Karena sekolah ingin berprestasi maka harus ada supervisi kepala sekolah, peran serta komite, pendidik, orang tua siswa, dan masyarakat di lingkungan sekolah. Upaya peningkatan mutu pendidikan yang dapat diterapkan antara lain; memberikan kesempatan kepada guru untuk meningkatkan kompetensinya, menyediakan buku-buku di perpustakaan, memberikan pelatihan kepemimpinan dan manajemen kepala sekolah, pembaharuan sarana prasarana untuk menunjang kenyamanan siswa selama di sekolah terutama di dalam kelas saat belajar, meningkatkan partisipasi masyarakat dan peran Orang tua yang membimbing mereka ketika berada di rumah dan pada akhirnya, yaitu kebijakan yang dibuat sekolah sesuai dengan kebutuhan sekolah.
EFEKTIVITAS KAPASITAS KELEMBAGAAN BADAN PENENANGGULANGAN BENCANA DAERAH (BPBD) PROVINSI SUMATERA BARAT DALAM MENGURANGI RISIKO BENCANA
Authors: Lestari Ade , Alhadi Zikri
Published: July 2021

This researxh describes the effectiveness of the institutional capacity of the West Sumatra Province BPBD in reducing disaster risk with all forms of effort and coordination. The purpose of this study was to determine the effectiveness of the institutional capacity of West Sumatra Province BPBD in an effort to reduce disaster risk. This research method is a qualitative method. The locations of the study were scattered at the West Sumatra Province BPBD office, informant's residence and via telephone. Data collection uses interviews, observation, and study documentation. The research informants were several heads of departments, section heads and staff at the West Sumatra Province Regional Development Planning Agency and several members of the forum and non-governmental disaster risk reduction organizations. The results of the research found are case examples, supporting and inhibiting factors, from which conclusions can be drawn on how effective the BPBD of West Sumatra Province is in reducing disaster risk.