bluuebunny/crossref_metadata_2025 huggingface dataset:
Shared responsibility between teachers predicts student achievement: A mixed methods study in Norwegian co-taught literacy classes
Authors: Gourvennec Aslaug Fodstad , Solheim Oddny Judith , Foldnes Njål , Uppstad Per Henning , McTigue Erin M.
Published: December 2022

Having two teachers work collaboratively in the same class has been suggested as a possible solution to several instructional challenges, including the inclusion of students with special needs in mainstream classrooms and as part of school-wide prevention models to increase student achievement. In this, shared responsibility between teachers is regarded as a prerequisite to successful co-teaching. However, few studies have investigated whether shared responsibility between teachers actually leads to improved student achievement. This mixed methods study investigates shared responsibility in a sample of 148 classrooms where two general educators worked collaboratively in literacy instruction through first and second grade. First, we analysed whether the degree of shared responsibility between the two teachers for planning, enacting, and evaluating literacy instruction predicted student reading when controlling for pre-reading skills at baseline. Second, we carried out in-depth individual interviews with six collaborative teacher dyads purposefully selected from high- and low-performing classrooms to investigate what characterized their sharing of responsibility. The results show that shared responsibility significantly predicts students’ reading achievement. Further, the interviews reveal a surface level collaboration between coteachers in low-performing classes, yet a more profound level of collaboration with influence on key teaching decisions in high-performing classes.
Assessment of tricalcium phosphate/titanium dioxide (TCP/TiO2) nanocomposite scaffold compared with bone autograft and hydroxyapatite (HA) on the healing of segmental femur bone defect in rabbits
Authors: Sonbolekar Hoseyn , Alireza Jahandideh , Ahmad Asghary , Hesaraki Saeed , Akbarzadeh Abolfazl
Published: December 2022

Bone healing is a tissue process after a surgical operation. Many formulated materials have been designed for improving these procedures. The purpose of this study was to evaluate the effectiveness of nanocomposite tricalcium phosphate scaffolds combined with Titanium dioxide scaffold (TCP/TiO2) for femoral defects regeneration in rabbits. We studied 80 mature male New Zealand white rabbits weighing between 3 and 3.5 kg. Rabbits were subdivided into four groups. Anesthesia was performed before surgical operation by 50 mg/kg Ketamine 10% and 5 mg/kg xylazine 5% intramuscularly. We inducted a 6 × 5 mm diameter cylinder defect on the femur. Animals were separated into four trial groups of 20 animals each. After defecting, the experimental groups include control, autograft, hydroxyapatite, and TCP/TiO2 (received pure nanocomposite TCP/TiO2 material). A pathologist evaluated the sections on days 15, 30, 45, and 60 after surgery. The improvement of new and lamellar bone formation was the best in the nanocomposite TCP/TiO2 group at various point times, especially 60 days after surgery. We found that TCP/TiO2 nanocomposite has a significant improving function in the remodeling of bone in the defect areas.
A comparison of banks and real estate intermediaries as house sellers
Authors: Montalvo Jose Garcia , Raya Josep Maria
Published: December 2022

The foreclosure crisis associated with the banking crisis transformed banks in the hardest-hit countries into real estate brokers. The main novelty of this paper is to study banks as sellers of their own foreclosed properties and compare banks’ sales outcomes with those of traditional agents in the real estate market. We compare the list price, selling price, time on market and price discount of traditional real estate companies (TRECs) and bank-owned real estate companies (BRECs). We find evidence of a higher selling price, higher list price and longer time on market (TOM) for BRECs than for TRECs. Our findings are consistent with BRECs displaying greater patience as well as lower risk aversion. However, these explanations are not enough to fully account for the magnitudes of the coefficients. The empirical estimates suggest that information in the housing market may also be a source of distortions. In fact, the main aim of the sale varies depending on the incentives of the company. BREC sellers are banks that own the properties for sale, so their incentives are to maximize selling prices to reduce the loss charged to their annual results, while TRECs seek to minimize the TOM.
The Polish Catholic Church in Martin Coronado, Buenos Aires, and its Role in the Life of the Argentinian Polish Community during the COVID-19 Pandemic
Authors: Ziółkowska-Weiss Kamila
Published: December 2022

The objective of the article is to determine the role of the Catholic Church in the life of the Polish community in Argentina as exemplified by the Polish Catholic Centre in Martin Coronado during the pandemic caused by the SARS-Cov-2 coronavirus. The article presents opinions of the Polish community in Buenos Aires concerning the priestly service of the Bernardine friars during the pandemic. The research confirms that the Argentinian Polish community evaluates the work of the clergymen very highly and emphasises that thanks to their support, peace and constant contact through, inter alia, introduction of the broadcast of the masses in the Polish language, they felt the care and support of the priests, which was necessary during social isolation. The article will also present a proposal of the model of activities that Polish priests from Martin Coronado can implement during the COVID-19 pandemic so that the faithful feel even greater support and closeness to the Polish missionary centre in Argentina.
Strange Properties of Linear Reservoirs in the Infinitely Large Limit for Prediction of Continuous-Time Signals
Authors: Hsu Alexander , Marzen Sarah E.
Published: December 2022

Large linear reservoirs, while not necessarily of practical utility, might provide insight to large nonlinear reservoirs. Our study of large linear reservoirs in the context of improving predictive capabilities suggests that: one desires to be near the edge of instability; and random matrix theory guarantees that the performance of large linear random matrices is only dependent on how weights in the weight matrix are chosen and not the individual weights. It also seems as though dynamic and static weights are quite different in performance. We comment on how these lessons may or may not apply to the large nonlinear reservoirs that are typically used for prediction applications.
On the Bott index of unitary matrices on a finite torus
Authors: Toniolo Daniele
Published: December 2022

This article reviews the foundations of the theory of the Bott index of a pair of unitary matrices in the context of condensed matter theory, as developed by Hastings and Loring (J. Math. Phys. 51, 015214 (2010), Ann. Phys. 326, 1699 (2011)), providing a novel proof of the equality with the Chern number. The Bott index is defined for a pair of unitary matrices, then extended to a pair of invertible matrices and homotopic invariance of the index is proven. An insulator defined on a lattice on a two-torus, that is a rectangular lattice with periodic boundary conditions, is considered and a pair of quasi-unitary matrices associated to this physical system are introduced. It is shown that their Bott index is well defined and the connection with the transverse conductance, the Chern number, is established proving the equality of the two quantities, in certain units.
Why good work in philosophical bioethics often looks strange
Authors: Moen Ole Martin
Published: December 2022

Papers in philosophical bioethics often discuss unrealistic scenarios and defend controversial views. Why is that, and what is this kind of work good for? My aim in the first part of this paper is to specify how philosophical bioethics relates to other types of work in bioethics, and to explain the role of the unrealistic scenarios and the controversial views. In the second part, I propose three strategies for doing research in philosophical bioethics that makes a valuable contribution to the bioethics community at large.
A novel motion-reconstruction method for inertial sensors with constraints
Authors: Neurauter Rene , Gerstmayr Johannes
Published: December 2022

Motion reconstruction for rigid bodies and rigid-body frames using data from inertial measurement units (IMUs) is a challenging task. Position and orientation determination by means of IMUs is erroneous, as deterministic and stochastic errors accumulate over time. The former of which errors can be minimized by standard calibration approaches, however, sensor calibration with respect to a common reference coordinate system to correct misalignment, has not been fully addressed yet. The latter stochastic errors are mostly reduced using sensor fusion. In this paper, we present a novel motion-reconstruction method utilizing optimization to correct measured IMU data by means of correction polynomials to minimize the deviation of motion constraints. In addition, we perform gyrometer and accelerometer calibration with an industrial manipulator to address deterministic IMU errors, especially misalignment. To evaluate the performance of the novel methods, two types of experiments, one at constant orientation and another with simultaneous translation and rotation, were conducted utilizing the manipulator. The experiments were repeated for five individual IMUs successively. Application of the calibration and optimization methods yielded an average decrease of 95% in the maximum position error compared to the results of common motion reconstruction. Moreover, the average position error over the measurement duration decreased by nearly 90%. The proposed method is applicable to velocity, position, and orientation constraints for every experiment that starts and ends at standstill.
The “Double Trap” in China—Multiple Equilibria in Institutions and Income and their Causal Relationship
Authors: Glawe Linda , Wagner Helmut
Published: December 2022

While institutions are said to be poor in China in cross-country comparison, recent research indicates that at the provincial level, institutional quality plays in fact an important role for the economic success of a province, municipality, or autonomous region in China. Our paper aims to add further arguments to this discussion by focusing on the concept of club convergence. In particular, we analyze whether institutional quality in low-income provincial level administrative divisions converges to the level experienced by relatively highly developed ones or whether there exist multiple institutional clubs over the period 1997–2007 by using the log t test proposed by Phillips and Sul (Econometrica 75(6):1771–1855, 2007). Our findings indicate that there exist multiple institutional clubs within China, three rather small clubs which follow an above-average high institutional quality path and two clubs which find themselves on a relatively low institutional quality path and which together account for the majority of provinces and autonomous regions. Using the same methodology, we find that various members of the poor institutional clubs are additionally caught in a low-income trap. In a next step, we analyze the causal relationship between poor institutional traps and low-income traps in China by using a recursive bivariate probit model. We find evidence that institutional traps are important determinants of income traps, giving rise to the recently identified phenomenon of a ‘double trap’. Finally, our findings indicate that human capital and urbanization are additional important determinants of income traps, while globalization is decisive for avoiding poor institutional traps.
Learning from Polls During Electoral Campaigns
Authors: Stoetzer Lukas F. , Leemann Lucas , Traunmueller Richard
Published: December 2022

Voters’ beliefs about the strength of political parties are a central part of many foundational political science theories. In this article, we present a dynamic Bayesian learning model that allows us to study how voters form these beliefs by learning from pre-election polls over the course of an election campaign. In the model, belief adaptation to new polls can vary due to the perceived precision of the poll or the reliance on prior beliefs. We evaluate the implications of our model using two experiments. We find that respondents update their beliefs assuming that the polls are relatively imprecise but still weigh them more strongly than their priors. Studying implications for motivational learning by partisans, we find that varying adaptation works through varying reliance on priors and not necessarily by discrediting a poll’s precision. The findings inform our understanding of the consequences of learning from polls during political campaigns and motivational learning in general.
Opportunities for variable rate application of nitrogen under spatial water variations in rainfed wheat systems—an economic analysis
Authors: Tenreiro Tomás R. , Avillez Francisco , Gómez José A. , Penteado Manuel , Coelho José C. , Fereres Elías
Published: December 2022

In fields of undulating topography, where rainfed crops experience different degrees of water stress caused by spatial water variations, yields vary spatially within the same field, thus offering opportunities for variable rate application (VRA) of nitrogen fertilizer. This study assessed the spatial variations of yield gaps caused by lateral flows from high to low points, for rainfed wheat grown in Córdoba, Spain, over six consecutive seasons (2016–2021). The economic implications associated with multiple scenarios of VRA adoption were explored through a case study and recommendations were proposed. Both farm size (i.e., annual sown area) and topographic structure impacted the dynamics of investment returns. Under current policy-price conditions, VRA adoption would have an economic advantage in farms similar to that of the case study with an annual sown area greater than 567 ha year−1. Nevertheless, current trends in energy prices, transportation costs and impacts on both cereal prices and fertilizers costs enhance the viability of VRA adoption for a wider population of farm types. The profitability of adopting VRA improves under such scenarios and, in the absence of additional policy support, the minimum area for adoption of VRA decreases to a range of 68–177 ha year−1. The combination of price increases with the introduction of an additional subsidy on crop area could substantially lower the adoption threshold down to 46 ha year−1, making VRA technology economically viable for a much wider population of farmers.
Vocabulary, text coverage, word frequency and the lexical threshold in elementary school reading comprehension
Authors: Ludewig Ulrich , Hübner Nicolas , Schroeder Sascha
Published: December 2022

Vocabulary knowledge is one of the most important elements of reading comprehension. Text coverage is the proportion of known words in a given text. We hypothesize that text comprehension increases exponentially with text coverage due to network effects and activation of prior knowledge. In addition, the lexical threshold hypothesis states that text comprehension increases faster above a certain amount of text coverage. The exponential relationship between text coverage and text comprehension, as well as the lexical threshold, are at the heart of text comprehension theory and are of great interest for optimizing language instruction. In this study, we first used vocabulary knowledge to estimate text coverage based on test scores from N = 924 German fourth graders. Second, we compared linear with non-linear models of text coverage and vocabulary knowledge to explain text comprehension. Third, we used a broken-line regression to estimate a lexical threshold. The results showed an exponential relationship between text coverage and text comprehension. Moreover, text coverage explained text comprehension better than vocabulary knowledge, and text comprehension increased more quickly above 56% text coverage. From an instructional perspective, the results suggest that reading activities with text coverage below 56% are too difficult for readers and likely inappropriate for instructional purposes. Further applications of the results, such as for standard setting and readability analyses, are discussed.
Losing centrality and socialization of Islam in Suzhou Memories, identities and positionality around the city mosques
Authors: Cappelletti Alessandra
Published: December 2022

Cultural and political alterity in China is levelled by disrupting local communities and networks, both necessary to keep memories and sense of identity alive through sharing and socialising. By taking Suzhou’s mosques as focal lens, the author assesses an experiential void which is politically and socially created, and shows the consequences of rewriting history. The broken nexus between buildings, communities and memories impacts the historical centrality and socialization of Islam in Suzhou, where communities are dispersed and shared memories are lost. Mosques’ positionality in the urban fabric is assessed through interviews and interaction with local Muslims, and the identification of past surrounding communities and networks. The assessment of the heterotopic dimension and contested memories of Suzhou’s mosques in a contemporary context — performed by collecting historical, intellectual, topographical and architectural fragments — allows us to grasp the highly symbolic dimensions of a past diversity in identity spaces. The role of communities in relation with the city’s rich intellectual past — including its tradition of literati translating Islamic classics from Persian to Chinese — is understood as central, together with a spiritual geography made of connections and relations among places.
Effects of Transcranial Direct Current Stimulation (t-DCS) of the Cerebellum on Pain Perception and Endogenous Pain Modulation: a Randomized, Monocentric, Double-Blind, Sham-Controlled Crossover Study
Authors: Stacheneder Regina , Alt Laura , Straube Andreas , Ruscheweyh Ruth
Published: December 2022

Accumulating evidence demonstrates a role of the cerebellum in nociception. Some studies suggest that this is mediated via endogenous pain modulation. Here, we used t-DCS to test the effects of modulation of cerebellar function on nociception and endogenous pain modulation. Anodal, cathodal, and sham cerebellar t-DCS were investigated in a cross-over design in 21 healthy subjects. The nociceptive flexor (RIII) reflex, conditioning pain modulation (CPM), and offset analgesia (OA) paradigms were used to assess endogenous pain modulation. Somatosensory evoked potentials (SEPs) and pain ratings were used to assess supraspinal nociception and pain perception, respectively. No significant t-DCS effects were detected when including all t-DCS types and time points (baseline, 0, 30, 60 min post t-DCS) in the analysis. Exploratory analysis revealed an increased RIII reflex size immediately after cathodal t-DCS (compared to sham, P = 0.046, η2p = 0.184), in parallel with a trend for a decrease in electrical pain thresholds (P = 0.094, η2p = 0.134), and increased N120 SEP amplitudes 30 min after cathodal compared to anodal t-DCS (P = 0.007, η2p = 0.374). OA was increased after anodal compared to sham stimulation (P = 0.023, η2p = 0.232). Exploratory results suggested that cathodal (inhibitory) cerebellar t-DCS increased pain perception and reduced endogenous pain inhibition while anodal (excitatory) t-DCS increased endogenous pain inhibition. Results are principally compatible with activation of endogenous pain inhibition by cerebellar excitation. However, maybe due to limited t-DCS skull penetration, effects were small and unlikely to be clinically significant.
USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway
Authors: Zhou Yuhui , Zhao Yunxia , Ma Wei , Zhang Lin , Jiang Yuanzhu , Dong Wei
Published: December 2022

Background

This study aimed to identify genes related to lung adenocarcinoma (LUAD) and investigate the effects and molecular mechanisms of coiled-coil-helix-coiled-coil-helix domain containing 4 (CHCHD4) in the progression of LUAD.

Methods

The GEPIA database was used to evaluate the differential expression of CHCHD4 and the survival data of LUAD patients compared to controls. TCGA-LUAD database, JASPAR website, and GSEA were used to analyse the relationship between CHCHD4 and the upstream stimulating factor 1 (USF1) or MYC pathways. The proliferation, apoptosis, migration, and invasion of LUAD cells were evaluated using cell counting kit-8, 5-ethynyl-2′-deoxyuridine, colony formation, flow cytometry, wound healing, and transwell assays. qRT-PCR, western blotting, and immunohistochemistry were used to detect the mRNA and protein expression, respectively. Furthermore, xenograft tumours from nude mice were used to verify the effect of CHCHD4 on LUAD in vivo.

Results

CHCHD4 overexpression was found in LUAD tumor tissues and cells, and high CHCHD4 was associated with a poor prognosis. Interestingly, CHCHD4 knockdown suppressed the malignant phenotype of the LUAD cells. Moreover, we found that USF1 upregulated CHCHD4 and promoted LUAD progression. CHCHD4 knockdown also inhibited the progression of LUAD. In addition, CHCHD4 knockdown suppressed xenograft tumour growth.

Conclusion

USF1-CHCHD4 axis can promote LUAD progress, which may be through activating MYC pathway.
The Rule of Law as a Constitutional Mandate for the EU
Authors: Schroeder Werner
Published: December 2022

The rule of law and the other values contained in Article 2 of the Treaty on European Union (Art 2 TEU) comprise the constitutional identity of the European Union (Union). These values form part of the Union’s very foundation. Art 3(1) and (6) TEU, in conjunction with Art 2 TEU, declare the Union’s aim to promote and pursue the rule of law as one of its core values. These provisions indicate that the rule of law is not only a constitutional principle but gives the Union a mandate to shape its policies accordingly in order to create an enabling ecosystem for the rule of law in the Member States. The Union may counter internal threats to the rule of law, but it can and should also take positive legal action to strengthen and consolidate the rule of law in the Member States by making use of its sectoral law-making competences. Proactively, the rule of law must be implemented and specified through Union secondary law and made the yardstick for legislative, administrative and judicial activity in the Member States.
RETRACTED ARTICLE: Vibration test and robust optimization analysis of vehicle suspension system based on Taguchi method
Authors: Xiong Jianqiang
Published: December 2022

The suspension system is the main component that affects the NVH (Vibration, Noise, Harshness) performance of vehicles. By optimizing the key influence factors to improve the vibration of the suspension system, the comfort of car deriving could be improved greatly. Based on this consideration, the researcher proposes to apply the Taguchi method to study the contribution of different factors to the vibration of the suspension system and obtain the main influencing factors that need to be controlled. In the research, the researcher established an active suspension test system and designed a scheme which contains four factors and three levels to test the stiffness and damping properties of the front and rear suspensions under different parameters by setting the A-level road power spectrum as the input excitation of the suspension system. According to the weighted root-mean-square of acceleration, the researcher conducted the optimized calculation and analysis. It is found that the vibration contribution of each influencing factor is: the suspension stiffness is 46.81%, the front suspension damping is 15.87%, the front suspension stiffness is 4.30%, and the influence of the rear suspension damping is negligible. Results of tests and analysis offer an accurate and reliable reference for evolving suspension systems and improving the NVH.
Residue alterations within a conserved hydrophobic pocket influence light, oxygen, voltage photoreceptor dark recovery
Authors: Hemmer Stefanie , Schulte Marianne , Knieps-Grünhagen Esther , Granzin Joachim , Willbold Dieter , Jaeger Karl-Erich , Batra-Safferling Renu , Panwalkar Vineet , Krauss Ulrich
Published: December 2022

Light, oxygen, voltage (LOV) photoreceptors are widely distributed throughout all kingdoms of life, and have in recent years, due to their modular nature, been broadly used as sensor domains for the construction of optogenetic tools. For understanding photoreceptor function as well as for optogenetic tool design and fine-tuning, a detailed knowledge of the photophysics, photochemistry, and structural changes underlying the LOV signaling paradigm is instrumental. Mutations that alter the lifetime of the photo-adduct signaling state represent a convenient handle to tune LOV sensor on/off kinetics and, thus, steady-state on/off equilibria of the photoreceptor (or optogenetic switch). Such mutations, however, should ideally only influence sensor kinetics, while being benign with regard to the nature of the structural changes that are induced by illumination, i.e., they should not result in a disruption of signal transduction. In the present study, we identify a conserved hydrophobic pocket for which mutations have a strong impact on the adduct-state lifetime across different LOV photoreceptor families. Using the slow cycling bacterial short LOV photoreceptor PpSB1-LOV, we show that the I48T mutation within this pocket, which accelerates adduct rupture, is otherwise structurally and mechanistically benign, i.e., light-induced structural changes, as probed by NMR spectroscopy and X-ray crystallography, are not altered in the variant. Additional mutations within the pocket of PpSB1-LOV and the introduction of homologous mutations in the LOV photoreceptor YtvA of Bacillus subtilis and the Avena sativa LOV2 domain result in similarly altered kinetics. Given the conserved nature of the corresponding structural region, the here identified mutations should find application in dark-recovery tuning of optogenetic tools and LOV photoreceptors, alike.

Graphical abstract
Editorial
Authors: Asghar Basim H.
Published: December 2022

The Journal of Umm Al-Qura University for Applied Sciences aspires to leadership and excellence in publishing distinguished scientific research in Applied Science disciplines
A Critical Assessment of the Intergovernmental Panel on Climate Change
Authors: Hulme Mike
Published: December 2022

The Intergovernmental Panel on Climate Change (IPCC) has become a hugely influential institution. It is the authoritative voice on the science on climate change, and an exemplar of an intergovernmental science-policy interface. This book introduces the IPCC as an institution, covering its origins, history, processes, participants, products, and influence. Discussing its internal workings and operating principles, it shows how IPCC assessments are produced and how consensus is reached between scientific and policy experts from different institutions, countries, and social groups. A variety of practices and discourses – epistemic, diplomatic, procedural, communicative – that make the institution function are critically assessed, allowing the reader to learn from its successes and failures. This volume is the go-to reference for researchers studying or active within the IPCC, as well as invaluable for students concerned with global environmental problems and climate governance. This title is also available as Open Access via Cambridge Core.
Cross Purposes
Authors: Waligórska Magdalena
Published: December 2022

No other symbol is as omnipresent in Poland as the cross. This multilayered and contradictory icon features prominently in public spaces and state institutions. It is anchored in the country's visual history, inspires protest culture, and dominates urban and rural landscapes. The cross recalls Poland's historic struggles for independence and anti-Communist dissent, but it also encapsulates the country's current position in Europe as a self-avowed bulwark of Christianity and a champion of conservative values. It is both a national symbol – defining the boundaries of Polishness in opposition to a changing constellation of the country's Others – and a key object of contestation in the creative arts and political culture. Despite its long history, the cross has never been systematically studied as a political symbol in its capacity to mobilize for action and solidify power structures. Cross Purposes is the first cultural history of the cross in modern Poland, deconstructing this key symbol and exploring how it has been deployed in different political battles.
Modern Mathematical Logic
Authors: Mileti Joseph
Published: December 2022

This textbook gives a complete and modern introduction to mathematical logic. The author uses contemporary notation, conventions, and perspectives throughout, and emphasizes interactions with the rest of mathematics. In addition to covering the basic concepts of mathematical logic and the fundamental material on completeness, compactness, and incompleteness, it devotes significant space to thorough introductions to the pillars of the modern subject: model theory, set theory, and computability. Requiring only a modest background of undergraduate mathematics, the text can be readily adapted for a variety of one- or two-semester courses at the upper-undergraduate or beginning-graduate level. Numerous examples reinforce the key ideas and illustrate their applications, and a wealth of classroom-tested exercises serve to consolidate readers' understanding. Comprehensive and engaging, this book offers a fresh approach to this enduringly fascinating and important subject.
Erste Erfahrungen mit einer Selbstmanagement-App in der stationären Suchtbehandlung
Authors: Kistner Saskia , Kramer Dietmar
Published: December 2022

Zusammenfassung: Zielsetzung: Um die Möglichkeiten smartphonebasierter Interventionen für die stationäre Entwöhnungstherapie in einer Rehabilitationsklinik zu nutzen, wurde die MeinSalus-App entwickelt. Ziel der Studie ist es, (1) die Akzeptanz (Nutzungsabsicht) der App bei Patienten sowie beim therapeutischen Personal zu untersuchen, (2) Prädiktoren der Akzeptanz auf der Grundlage eines erweiterten UTAUT (Unified Theory of Acceptance and Use of Technology-)Modells zu bestimmen und (3) Aufschlüsse über das Nutzungsverhalten zu bekommen. Methodik: 193 von 282 stationären Patienten (68,4 %) sowie 18 von 34 Therapeuten (52,9 %) beantworteten Fragebögen zur Akzeptanz (Nutzungsabsicht) der App und deren einzelnen Funktionen, zu UTAUT- und mHealth-bezogenen Variablen sowie zu ihrem Nutzungsverhalten. Ergebnisse: Die mittlere Nutzungsabsicht (Range 1–5) für die App insgesamt lag für Patienten bei 4.65 ( SD = 0.83) und für Therapeuten bei 4.07 ( SD = 0.62). Alter, mobile Internetnutzung, erwarteter Nutzen sowie Vorbehalte gegenüber der App erwiesen sich als signifikante Prädiktoren der Akzeptanz. Beim Nutzungsverhalten ergab sich ein differenziertes Bild für die unterschiedlichen Funktionen. Schlussfolgerungen: Es zeigte sich sowohl in der Patientenstichprobe als auch beim teilnehmenden therapeutischen Personal eine hohe Akzeptanz der App, was auf eine akzeptable Grundlage für eine Implementierung in der stationären Suchtbehandlung hindeutet. Studien zu Effekten der App sollten sich anschließen.
Co‐Creating Ethical Practices and Approaches for Fieldwork
Authors: Ryan‐Davis Juliet , Scalice Daniella
Published: December 2022

This article builds on perspectives shared at a Town Hall held during the 2021 AGU Fall Meeting focused on valuable lessons learned after publicized incidents of unethical field sampling. We present ideas and recommendations that are applicable across all Earth science disciplines. The major recommendation centers on equally valuing Indigenous and Western perspectives and knowledges, with actions that include building relationships with Indigenous communities, teaching ethical sampling protocols in geoscience curricula, and broadly implementing sharable sample archives. Co‐creating guidelines and practices with Indigenous partnership and expertise will ensure that equity is essential to geoethics and that geoscience is for society.
Timescales of Dike Growth and Chamber Deflation Constrain Magma Storage and Transport Pathways During Kīlauea's 2018 Lower East Rift Zone Intrusion
Authors: Townsend Meredith , Huang Mong‐Han
Published: December 2022

The intrusion of magma into Kīlauea's lower East Rift Zone in May 2018 led to the largest eruption along this segment of the volcano in over 200 years. As magma drained from the rift zone, leading to the collapse of Pu'u ‘Ō‘ō, pressure at the summit initially remained elevated and dropped at a slower rate compared to historical intrusion events. The anomalously long timescale of summit deflation suggests that the dike was fed from multiple sources. Here we show that dikes can serve as “dipsticks” of magma reservoirs and that the co‐evolution of dike growth and reservoir deflation constrains key magma transport parameters. Using coupled dike‐chamber models constrained by ground deformation and seismicity, we test four configurations of magma plumbing in order to illuminate which reservoirs and transport pathways were activated during the intrusion phase (30 April to 3 May) of the 2018 event. Slow summit deflation relative to the rate of dike propagation is best explained by a model in which the dike initiates from a compressible magma reservoir in the East Rift Zone, which then drains magma upstream from the Halema'uma'u reservoir through a shallow transport system. We use a Bayesian Markov chain Monte Carlo (MCMC) approach to estimate storage parameters for both reservoirs as well as the effective conductivity of the shallow magma transport system in the East Rift Zone, finding good agreement with independent estimates. Our results suggest that the rupture of reservoirs from within the East Rift Zone presents a unique hazard at Kīlauea.
Regional Perspective of Hadley Circulation and Its Uncertainties Among Different Datasets: Spread in Reanalysis Datasets
Authors: Li Yadi , Li Xichen , Xie Shang‐Ping , Zhang Gan , Wang Zhuo , Wang Wenzhu , Hou Yurong
Published: December 2022

The Hadley circulation (HC) is often considered zonally uniform and defined using the zonally averaged mass stream function (MSF). However, the longitudinal distribution of the overturning circulation is far from uniform, which has profound impacts on regional climates. This study uses a recently developed technique to examine the three‐dimensional MSF and thus the regional manifestations of the HC, and evaluates their climatology and seasonality in eight commonly used reanalysis datasets. This comparison emphasizes the spatial structure and the intensity of four regional Hadley cells, defined based on the natural boundaries of the three‐dimensional MSF. Specifically, two Hadley cells are located in the Indo‐Pacific warm pool region, with a strong and relatively deep cell extending from the equator to mid‐latitudes in each hemisphere. The other two cells are located over the East Pacific‐Atlantic sector, which is relatively weak and shallow, confined within the tropics and subtropics. The spatial structure of each regional cell is nearly identical among all reanalysis datasets, with pairwise spatial correlation coefficients higher than 0.9. However, the intensities of regional MSF show a large spread among these datasets. The range of this spread reaches up to about half of the means of all reanalysis datasets over the Indo‐Pacific warm pool region in the Northern Hemisphere. Further analysis reveals a large spread in the spatial structure and the amplitudes of the regional HC trends among different reanalyses. The findings highlight uncertainties in the regional circulation of modern reanalysis datasets and have implications for interpreting past and future circulation changes.
Detecting the Phase of Marine Boundary Layer Clouds: Some Implications for Cloud Albedo
Authors: Rampal N. , Davies R.
Published: December 2022

This study examines rare examples of marine boundary layer clouds that show a sharp transition from supercooled to glaciated phase without other significant changes in appearance. We used the Cloud‐Aerosol Lidar with Orthogonal Polarization's (CALIOP) cloud phase detection algorithm and cloud top height to identify these cases. Measurements by CALIOP were co‐located with those by the Moderate Resolution Imaging Spectroradiometer (MODIS) to determine spectral changes in reflected and emitted radiation along the glaciated to supercooled transition path. In every case, the MODIS 8.5–11 µm brightness temperature difference abruptly changed from positive to negative, with a relatively constant cloud top temperature. No change was seen in visible reflectivity, and only weak changes were detected in shortwave infrared reflectivity. These glaciated‐to‐supercooled transitions were incorrectly classified with the MODIS cloud phase classification algorithm. We show that, for boundary layer clouds, it is possible to improve the (passive) remote sensing of the cloud phase using only a single spectral difference in brightness temperature. Using this approach, we closely match CALIOP's climatological distributions of the cloud phase. Our work also indicates that a sudden change in the boundary layer cloud thermodynamic phase from supercooled to glaciated is not accompanied by a shift in shortwave albedo.
Quantifying Permanent Uplift Due To Lithosphere‐Hotspot Interaction
Authors: Lang Guy , ten Brink Uri S.
Published: December 2022

Vertical motions that accompany the passage of the lithosphere over a mantle hotspot can shed light on the nature of the hotspot and its effect on the lithosphere. However, quantifying the temporal vertical and spatial extent, is challenging due to the paucity of evidence in the geological record. Here, we utilize dense seismic and well data covering the intersection of the Great Meteor Hotspot (GMH) track with the U.S. Atlantic continental margin to constrain the surface expression of the hotspot passage under the lithosphere. The continuous sedimentary record of the eastern North American margin during its passage over the hotspot allows determination of the timing, magnitude, width and rate of denudation. We find that a ∼300 km wide region was denuded by up to 850 m between ∼97 and 86 Ma, ∼10 m.y. after the passage of the GMH. Stratigraphic relationships suggest a decaying rock uplift rate with time and no subsequent sagging. The broad, long‐lasting, and delayed uplift was modeled as a surface manifestation of either sub‐lithospheric mantle depletion, permanently eroded base of the continental lithosphere, or intrusions of depleted magma. We consider sub‐lithospheric depletion to be the most likely cause, based on seismic imaging results.
Efficacy of Longitudinal Training Walls to Mitigate Riverbed Erosion
Authors: Czapiga Matthew J. , Blom Astrid , Viparelli Enrica
Published: December 2022

The Waal Branch of the Rhine River has eroded over the last 150 years following channel straightening and narrowing. In 2014–2015 a pilot project replaced existing groynes over an 11 km long reach with three longitudinal training walls (LTWs) to mitigate channel bed erosion, among other purposes. Walls are lower than the river bank and split the flow between a primary and an auxiliary channel, which are hydraulically connected during floods. Water enters the auxiliary channel at three elevations (from bottom to top): via an entrance weir, through inter‐wall notches, and over the wall. Bathymetry and discharge data were collected for 5 years after construction, which is a first indication that longitudinal dams can help mitigate channel bed erosion and analyzed to understand how the walls partition water and sediment and whether erosion is mitigated by LTWs. As the river discharge increases, a larger fraction of flow is diverted from the primary channel into the auxiliary channel. After a flood, sediment is deposited in the primary channel near the upstream end of each wall and localized scour occurs where the auxiliary channel rejoins the primary channel. Between floods, the accumulated sediment disperses and scour pits tend to fill. We observe a net‐accumulation of sediment in the study domain 5 years after construction. Erosion is best mitigated when weir flow is minimized to keep bed material in the primary channel, but weir flow remains important at lower flows for ecological purposes.
Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
Authors: Belmonte-Fernández Alejandro , Herrero-Ruíz Joaquín , Galindo-Moreno María , Limón-Mortés M. Cristina , Mora-Santos Mar , Sáez Carmen , Japón Miguel Á. , Tortolero Maria , Romero Francisco
Published: December 2022

Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment of different types of cancer. However, it is common to find patients who respond well to treatment at first but later relapse due to the appearance of resistance to cisplatin. Among the mechanisms responsible for this phenomenon is the increase in DNA damage repair. Here, we elucidate the effect of cisplatin on the MRN (MRE11-RAD50-NBS1) DNA damage sensor complex. We found that the tumor suppressor FBXW7 is a key factor in controlling the turnover of the MRN complex by inducing its degradation through lysosomes. Inhibition of lysosomal enzymes allowed the detection of the association of FBXW7-dependent ubiquitylated MRN with LC3 and the autophagy adaptor p62/SQSTM1 and the localization of MRN in lysosomes. Furthermore, cisplatin-induced cell death increased MRN degradation, suggesting that this complex is one of the targets that favor cell death. These findings open the possibility of using the induction of the degradation of the MRN complex after genotoxic damage as a potential therapeutic strategy to eliminate tumor cells.
Will the PRESERFLO™ MicroShunt impact the future of trabeculectomy practice? A UK and Éire Glaucoma Society National Survey
Authors: Kuet Mong-Loon , Azuara-Blanco Augusto , Barton Keith , King Anthony J.
Published: December 2022

Background/objectives

To explore the attitudes of UK glaucoma specialists regarding the current and future practice of trabeculectomy and the novel PRESERFLO™ MicroShunt (PF-MS) device, and intentions to adopt the PF-MS into routine glaucoma surgical practice.

Methods

Online survey of UK and Éire Glaucoma Society members.

Results

43 glaucoma consultants completed the survey. All surgeons performed trabeculectomies (median of 40 annually) and 51% undertook PF-MS procedures (median of 22.5 annually). The mean duration of surgery was reported as 48.9 (SD 13.3) and 31.2 (SD 9.9) min for trabeculectomy and PF-MS respectively (p < 0.0001). For surgeons not currently using the PF-MS, 65% planned to do so. Respondents judged completion of 35 trabeculectomies and 10 PF-MS were required to achieve basic competence. 91% of participants predicted their trabeculectomy volume would decrease and 73% expected PF-MS usage to increase. Respondents reported a median of six and four follow-ups within 3 months post surgery for trabeculectomy and PF-MS respectively (p < 0.0001). Respondents reported trabeculectomy required more post-operative interventions than the PF-MS and 81.8% judged the patient experience to be better with the PF-MS. The PF-MS was deemed suitable for early visual field loss by 72% of respondents, severe visual field loss by 35% and normal tension glaucoma by 21%.

Conclusion

The PF-MS has seen rapid adoption in the UK. Respondents predict its usage will significantly increase whilst trabeculectomies will decrease. They report the PF-MS is quicker to learn and perform, and requires less post-operative follow-ups and interventions which may facilitate a more efficient service delivery for patients requiring glaucoma surgery.
Principles of mitoribosomal small subunit assembly in eukaryotes
Authors: Harper Nathan J. , Burnside Chloe , Klinge Sebastian
Published: December 2022

Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the mitochondrial genome that are assembled into oxidative phosphorylation complexes. Thus, mitoribosome biogenesis is essential for ATP production and cellular metabolism1. Here we used cryo-electron microscopy to determine nine structures of native yeast and human mitoribosomal small subunit assembly intermediates, illuminating the mechanistic basis for how GTPases are used to control early steps of decoding centre formation, how initial rRNA folding and processing events are mediated, and how mitoribosomal proteins have active roles during assembly. Furthermore, this series of intermediates from two species with divergent mitoribosomal architecture uncovers both conserved principles and species-specific adaptations that govern the maturation of mitoribosomal small subunits in eukaryotes. By revealing the dynamic interplay between assembly factors, mitoribosomal proteins and rRNA that are required to generate functional subunits, our structural analysis provides a vignette for how molecular complexity and diversity can evolve in large ribonucleoprotein assemblies.
A critical period of translational control during brain development at codon resolution
Authors: Harnett Dermot , Ambrozkiewicz Mateusz C. , Zinnall Ulrike , Rusanova Alexandra , Borisova Ekaterina , Drescher Amelie N. , Couce-Iglesias Marta , Villamil Gabriel , Dannenberg Rike , Imami Koshi , Münster-Wandowski Agnieszka , Fauler Beatrix , Mielke Thorsten , Selbach Matthias , Landthaler Markus , Spahn Christian M. T. , Tarabykin Victor , Ohler Uwe , Kraushar Matthew L.
Published: December 2022

Translation modulates the timing and amplification of gene expression after transcription. Brain development requires uniquely complex gene expression patterns, but large-scale measurements of translation directly in the prenatal brain are lacking. We measure the reactants, synthesis and products of mRNA translation spanning mouse neocortex neurogenesis, and discover a transient window of dynamic regulation at mid-gestation. Timed translation upregulation of chromatin-binding proteins like Satb2, which is essential for neuronal subtype differentiation, restricts protein expression in neuronal lineages despite broad transcriptional priming in progenitors. In contrast, translation downregulation of ribosomal proteins sharply decreases ribosome biogenesis, coinciding with a major shift in protein synthesis dynamics at mid-gestation. Changing activity of eIF4EBP1, a direct inhibitor of ribosome biogenesis, is concurrent with ribosome downregulation and affects neurogenesis of the Satb2 lineage. Thus, the molecular logic of brain development includes the refinement of transcriptional programs by translation. Modeling of the developmental neocortex translatome is provided as an open-source searchable resource at https://shiny.mdc-berlin.de/cortexomics.