bluuebunny/crossref_metadata_2025 huggingface dataset:
The Evolution of Measles in Romania Between 2016 and 2018. A comprehesive overview
Authors: Musat Simona Nicoleta , Nemes Maria Roxana , Moldovan Cosmin Alec , Harsovescu Tudor , Tudorache Ioan Sorin , Nemes Alexandra Floriana , Ion Laura , Rusu Elena
Published: January 2020

Measles is an ever-growing threat, a major public health issue, being responsible for a large number of deaths, especially in children. This paper aims to study all cases of measles in Romanian hospitals, cases reported by National School of Public Health, Management and Professional Development, Bucharest on a two year period of time; the study focuses on frequency and pattern territorial distribution of cases, temporal evolution, complication rates and the social pressure the such an infectious disease is putting onto the national health system. Data gathered shows a total number of 2,985 for 2016, 10,181 for 2017 and 8,364 for the entire 2018, with a grand total of 21,530 patients analyzed by our study. The analysis clearly shows, on one hand, a descending rate in vaccination coverage, compared with the national assigned target and, on the other hand, a continuous drop in vaccination rates with the first dose of Measles-mumps-rubella vaccine (MMR), both being in equal manner dangerous situations for the entire health system in Romania.
Tissue Engineering - Collagen Matrix Based Flaps - a Simple Construct. Experimental and Theoretical Aspects
Authors: Susanu Sidonia , Moraru Andreea , Costin Dan , Rusu Cristina Marcela , Agop Maricel , Cioca Gabriela
Published: January 2020

In our study we demonstrate the possibility to create a free flap using only a collagen matrix and a vascular pedicle. The processes of cell migration and differentiation, endogenous collagen synthesis, vascular network development, all rely on the arteriovenous loop introduced in the scaffold with no participation of surrounding vascularity. The flap has the capability to revascularize a full thickness skin graft, and also to establish vascular connections with adjacent vascular territories. Also, a fractal mathematical model was built based on spontaneous breaking symmetry to explain the behaviors of biostructures mentioned above.
The Therapeutic Relevance of Vitamin E
Authors: Anghel Lucretia , Baroiu Liliana , Beznea Adrian , Topor Gabi , Grigore Camelia Ana
Published: January 2020

Maintaining cellular homeostasis in the context of its normal metabolic function is achieved by establishing the balance between its own antioxidant capacity and the level of harmful compounds resulting from the mitochondrial activity and the immune system. One of the antioxidants involved in this process is vitamin E with its most active form - alpha-tocopherol, which exerts its functions through vitamin C. The main functions of this antioxidant are: regulation of platelet aggregation, cellular signaling, antioxidation. The therapeutic relevance of vitamin E has increased due to the incrimination of oxidative stress as a link in the pathophysiology of many chronic diseases. Respectively, the role most targeted is that of antioxidant.
Nicotine Activity on Healthy Oral Cells and Pharyngeal Tumor Cells
Authors: Sitaru Adrian , Cheveresan Adelina , David Vlad Laurentiu , Susan Razvan , Susan Monica , Stoian Dana , Szasz Florin , Balica Nicolae , Poenaru Marioara
Published: January 2020

A number of studies highlight the harmful effects of smoking and the extremely serious consequences of the majority of compounds found in cigarettes and cigarette smoke. Of these, nicotine has attracted attention due to the suspicion of a carcinogen compound. The present study investigated the effect of nicotine on primary gingival keratinocytes but also on pharyngeal tumor cells, by evaluating viability and apoptotic processes.
Oxidative Stress and Haematological Response in Rainbow Trout (Oncorhynchus Mykiss) Fed With Brewer Yeast (Saccharomyces Cerevisiae) as Nutritional Supplement
Authors: Coroian Cristian Ovidiu , Miresan Vioara , Raducu Camelia , Costea Claudia , Constantinescu Radu , Coroian Aurelia , Bentea Mihai Iacob , Simeanu Daniel , Radu-Rusu Cristina Gabriela , Latiu Calin , Cocan Daniel
Published: January 2020

Production of freshwater fish evolved constantly over the past decades in parallel with increasing the amount of ingredients conventionally used to feed these fish. From the main ingredients, those protein based are the most expensive and increasingly difficult to obtain. Fishmeal demands valuable alternative ingredients to replace it and yeasts seem to offer new protein sources, but not only, acting as probiotics in fish feed. We tested productive and physiological benefits of brewer yeast (Saccharomyces cerevisiae) added 1.5% in standard rainbow trout (Oncorhynchus mykiss) nutrition with Coppens fodder (2 mm granulation) with 45% crude protein (CP) over a period of 45 days, starting at an average live weight of 56.86 gramsin a classical system of breeding. Production parameters as average daily gain (ADG), total live gain (TLG) and feed conversion rate (FCR) but also hematologic and biochemical blood parameters have been evaluated. Yeast fed batch presented higher productive indices but not statistically represented. Significant differences were observed in hematological parameters for hemoglobin, very significant response of yeast fed batch regarding gamma globulins (GGL) level and significant changes were also recorded for total proteins (TP). Significantly lower values for amylase were revealed, while enzymatic profile shown significant differences in alkaline phosphatase (PAL) and creatinine phosphokinase (CPK). Overall, 1.5% of dried brewer yeast added to standard fodder in rainbow trout das led to a better use of feed and a strengthening of immunity.
Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms
Authors: Ichim Daniela Luminita , Duceac Letitia Doina , Marcu Constantin , Iordache Alin Constantin , Ciomaga Irina Mihaela , Luca Alina Costina , Bogdan Goroftei Elena Roxana , Mitrea Geta , Damir Daniela , Stafie Liviu
Published: January 2020

Some infectious agents frequently act on human body. Multi-drug resistant microorganisms (MDR) develop the capacity to stabilize biofilms. The use of antimicrobials loaded nanoparticles can defeat antibiotic resistance mechanism. The major aim of this study was the synthesis and physico-chemical characterization of Colistin molecules intercalated nanoparticles in order to enhance antibiotic efficacy against multi-drug resistant microorganisms. Advanced characterization techniques were used to analyze new nanostructures containing antibiotics in order to improve antimicrobial efficacy of the free drug. Nano-encapsulated Colistin is presumed to be more efficient in the eradication of severe infections caused by MDR.
The Management of Post-Tonsillectomy Morbidity in Patients With Sleep Apnoea
Authors: Stefanescu Cristian Dragos , Hainarosie Razvan , Alius Oana Ruxandra , Zainea Viorel
Published: January 2020

The Tonsillectomy in children or adults is an intervention commonly encountered in the ENT (Ear Nose and Throat) and�Head�and�Neck surgeon practice. The current tendency is to perform this type of surgery in major ambulatory surgery centers. Two objectives are thus pursued: first of all, the increase of the patient quality of life through the reintegration into the family as quickly as possible and secondly, the expenses associated with continuous hospitalization are reduced. Any tertiary (multidisciplinary) sleep center must ensure the complete diagnosis and treatment (including surgery) of sleep respiratory disorders. Under these conditions the selection of patients and especially the implementation of the specific protocols in order to control the postoperative complications it becomes essential. The present paper describes our experience of tonsillectomy as treatment for selected patients with chronic rhonchopathy (snoring) and mild to moderate obstructive sleep apnoea. It was presented the impact of antibiotics protocols in reducing the main morbid outcomes following tonsillectomy, in our day surgery center. The obtained results can also be a prerequisite for the integrative approach of the patients with sleep apnoea who were recommended surgical treatment. Considering the wide range of therapeutic modalities used in sleep apnoea, each with its specific advantages and disadvantages, more extensive and multicenter studies are needed.
Microwave - Assisted Synthesis of a Library of Pyrrolo[1,2-c]quinazolines
Authors: Georgescu Emilian , Dumitrascu Florea , Georgescu Florentina , Draghici Constantin , Dumitrescu Denisa
Published: January 2020

A library of new pyrrolo[1,2-c]quinazoline derivatives was obtained by the one-pot, three-component microwave-assisted synthesis, starting from quinazolines, 2-bromoacetyl derivatives and electron-deficient alkynes in 1,2-epoxybutane via 1,3-dipolar cycloaddition of quinazolinium N-ylides. This synthetic pathway offers a simple and rapid access to a large range of pyrrolo[1,2-c]quinazoline derivatives.
Comparative Research Concerning Hydrogen Storage by Platinum, Ruthenium and Iridium Doped Multiwall Carbon Nanotubes
Authors: Mirea Radu , Iordoc Mihai , Rimbu Gimi
Published: January 2020

A comparative research related to hydrogen adsorption capacity of multiwall nanotubes (MWNTs) doped with Platinum (Pt), Ruthenium (Ru) and Iridium (Ir) was carried out. Carbonic materials are considered to be one of the most promising materials for hydrogen adsorption and storage;they have different applications and fuel cells technology may be considered the most important of them. By using transitional metals for doping carbonic materials, the adsorption capacity increases, can approach the target of 6.5% weight ratio of H2 adsorbed in a substrate. The doping procedure consists in a physical or chemical method which involves metal for doping of a nano carbon structure. The use of ultrasounds is known in order to activate the substrate by inducing fractures within its internal structure. The adsorption capacity of the carbonic materials, which is a consequence of spill over phenomena, has been determined both by physical adsorption and by cyclic voltammetry. The substrates have been characterized in order to determine their BET and microspores surface and structure. The collected data related to the adsorption capacity have been processed by using a dedicated software. The results have been compared with the available data from literature and a good consistency was found.
Transtoracical Ecocardiographic Assessment of Severe Degenerative Aortic Stenosis with Normal Ejection Fraction and Low Transvalvular Gradient
Authors: Nanea Ioan Tiberiu , Nicolae Camelia , Iliesiu Adriana Mihaela , Plesa Florentina Cristina , Ples Liana , Munteanu Alice , Diaconu Magdalena , Bisoc Alina , Ciucurel Constantin , Iconaru Elena Ioana , Paunescu Alina
Published: January 2020

Purpose of the study: echocardiographic evaluation of the form of degenerative aortic stenosis (DAS) with preserved ejection fraction (EF) and low transvalvular gradient, in order to formulate the indication of valvular prosthesis as early as possible; retrospective observational study that includes patients admitted or sent for ambulatory evaluation by other medical services. The echocardiographic parameters used: systolic and diastolic indices, tissue and spectral, mitral and tricuspid veins, aortic orifice area, maximal aortic systolic velocity, maximal and medium aortic transvalvular gradient, myocardial mass index, volume of left atrium, left ventricular (LV) thickness. 42 patients with severe DAS and preserved EF, average age 71.7�3.85 years. Two groups were isolated: A - with increased gradient (22 patients) and B - with low gradient (20 patients). The gender distribution was comparable: women representing 33% in group A versus 30% in group B. The average age of women in both groups was higher than that of the men: in group A: 72�8 years in the case of women vs. 67�6 years in the case of men and in group B 72�3.5 years in women vs. 68�6 years in men. Apical displacement of the mitral ring: 14�2mm in lot A vs. 11�2mm in lot B. Myocardial mass index: 120 � 9g/m2 in lot A vs. 126 � 12g/m2 in lot B. Left ventricular filling ratio E/e�: 8�2 in lot A vs. 13�2 in lot B; maximum aortic systolic velocity: 4.3�0.9m/s in lot A vs. 3.1�0.8m/s in lot B; maximum gradient: 73.9�10mmHg in lot A vs. 37�12mmHg in lot B; aortic orifice area: 0.80�10.5 in lot A vs. 0.79�0.07 in lot B. Statistical analysis shows the Pearson correlation index r with the highest values of 95% at the significance threshold between the aortic orifice area and the valve opening (r=0.87), the ratio E/e� (r=-0.85) and diastolic thickness of the posterior wall of the aortic left ventricle (r = 0.78). Aortic stenosis with preserved ejection fraction and low gradient was more common in men. The filling ratio E/e� was increased (13 � 2) in group B, suggesting the increase of filling pressures of LV in patients with DAS and low transvalvular gradient. Tissue spectral systolic and longitudinal velocities were lower in group B, suggesting the onset of systolic LV dysfunction. The aortic valve opening and the E/e� ratio showed the highest correlation coefficient with the area of the aortic orifice in both groups. The myocardial mass index and the thickness of the walls of the LV cavity are similar in the two groups, suggesting that the reduction of the LV cavity through hypertrophy may not explain, at least in totality, the form of DAS with low gradient and preserved ejection fraction.
Influence of Isothermal Heating on the Curie Temperature of FeCoB Bulk Amorphous Alloy
Authors: Jez Kinga , Jez Bartlomiej , Pietrusiewicz Pawel
Published: January 2020

The article presents the results of research on the thermal treatment of amorphous alloys. As part of the work, an alloy with a chemical composition Fe63Co8Y8W1B20 was produced by rapid cooling. The method used to aspirate the liquid alloy into the copper mold was used. The produced material was subjected to annealing at 940K for 10 minutes. The alloy, after solidification and after heat treatment, was subjected to structure testing by means of X-ray diffraction. The soaking process led to the partial crystallization of the amorphous precursor. Using the Faraday magnetic balance, curves of the magnetic saturation polarization as a function of temperature were recorded, on the basis of their analysis, the Curie temperature of the produced materials was determined. Using the vibration magnetometer, the primary curves of magnetization and static magnetic hysteresis loops were measured. The alloy after the soaking process was characterized by higher Curie temperature and magnetically hard properties. The test results confirm the possibility of modifying the magnetic properties of high-temperature alloys through a suitably designed heat treatment.
Percutaneous Aspiration-Injection-Reaspiration of Hepatic Cystic Echinococcosis
Authors: Papancea Adelina , Georgescu Stefan Octavian , Vintila Dan , Lupascu Corina Ursulescu , Timofte Daniel , Fotea Vasile , Petrariu Florin , Ciuntu Bogdan Mihnea
Published: January 2020

Human echinococcosis is a zoonotic infection caused by larval forms (metacestodes)of the tapeworm of the genus echinococcus found in the small intestines of carnivores. Humans are only incidentally infected. The liver is the most frequent site for the cystic lesions seen in hydatid disease, followed by the lung, the brain, and other visceral. Surgery is the recommended treatment for hepatic hydatid cysts. However, drug therapy and percutaneousdrainage have recently been introduced as alternative treatments. We present the case of a 68 year old female pacient that admitted in our clinic for pain in the superior abdominal region. The ecography performed revealed a large cystic formation about 700 mL with a diameter of 10 cm in the right lobe of the liver. We performed a Percutaneous Aspiration-Injection-Reaspiration Drainage (PAIR) under Albendazol treatment before and after the procedure without any incidents. The histopathological examination concluded the diagnosis of hydatid hepatic cyst. Percutaneous drainage is minimally invasive and very effective in the treatment of hepatic hydatidosis. Percutaneous aspiration of a documented or suspected hydatid cyst was long considered to be contraindicated to avoid the risk of leakage of cyst contents, which can lead to anaphylaxis and seeding of intraperitoneal structures. In the our case report the hydatid hepatic cyst was a large univezicular cyst, with a approachable localization in the liver, on a pacient without any other medical problems that was suitable for PAIR, and after the procedure we didn�t identified any of the complication reported in literature. The effectiveness of PAIR method allowed a short period of hospitalization with ambulatory follow up with benefits on the both sides , the pacient social integration and medical system economy.
Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic
Authors: Korodi Andrei Dan , Furau Cristian , Furau Gheorghe , Dimitriu Mihai , Socea Bogdan , Codreanu Ada Maria , Botezatu Dragos , Dumnici Alexandru , Totolici Bogdan , Barbu Ion , Gheorghiu Nicolae , Gheorghiu Diana Claudia , Miutescu Eftimie
Published: January 2020

Gastrointestinal stromal tumors (GIST�sare the most common mesenchymal neoplasms of the alimentary tract. Angiogenesis is an essential condition in the growth and development of tumors, especially in the case of GISTs due to their particular behavior. The aggressive behavior depends on the size and site of the tumor in close relationship with the intratumoral vascular development. The purpose of this study is to investigate, using immunohistochemical stainings, the types of intratumoral vessels in GIST�s, knowing the interrelation between the tumor angiogenesis and the response to the targeted antivascular therapy, influencing directly the prognosis. In our research, in all 37 cases the most numerous vessels were the immature and intermediate ones, signaling an increased angiogenic activity. The perivascular cell free vessels are the most sensitive at antivascular therapy with tyrosine kinase receptor inhibitors, providing a good response and prognosis to the treatment. Immature vessels evaluation especially, could be a an important sign in assessment of the effectiveness of antivascular therapy in GIST.
Primary Systemic Amyloidosis - an Unusual Cause of Diarrhea
Authors: Plaisanu Carmen , Baleanu Vlad Dumitru , Davitoiu Dragos Virgil , Meianu Corina , Diculescu Mircea , Ciora Cosmin Alexandru
Published: January 2020

The amyloidosis is a group of rare diseases caused by extracellular deposition of amyloid. It may affect multiple organs with protean manifestations, thus often causing delayed or incorrect diagnoses. We report a case of gastrointestinal involvement in primary systemic amyloidosis (PSA) in a patient complaining of diarrhea and weight loss. The diagnosis was confirmed by endoscopic biopsies of upper digestive tract and by multidisciplinary evaluation for systemic involvement.
Dispersion of Nicotine Circular Birefringence
Authors: Stratulat Ioan Sorin , Scripa (Tudose) Adina , Barzic Andreea Irina , Dimitriu Dan Gheorghe , Dorohoi Dana Ortansa , Luca Alina Costina
Published: January 2020

The dispersion of nicotine�s circular birefringence in the visible range was determined from the channeled spectrum and verified using a polarimeter standardized in yellow light of a Natrium lamp. The obtained results are in agreement with the data from literature.
Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit
Authors: Golli Andreea Loredana , Nitu Floarea Mimi , Balasoiu Maria , Nemes Roxana Maria , Tudorache Sorin Ioan , Mahler Boca Beatrice , Olteanu Mihai
Published: January 2020

The emergence of multidrug-resistant (MDR) pathogens, especially for intensive care unit (ICU) patients is a serious threat to public health. To determine the frequency and antibiotic resistance pattern of bacterial pathogens isolated from tracheal aspirates of the patients admitted in ICU. The retrospective study included endotracheal aspirates from 734 patients admitted to the ICU, from January to December 2017. The analysis of the resistance patterns for the action of the appropriate antibiotics was performed using Vitek 2 Compact system and diffusion method. A total of 985 bacterial isolates were obtained, of which 227 strains of Klebsiella spp. (23.04%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (170- 17.25%), MRSA (134- 13.60%). Isolation rates indicates a higher value for male patients and elderly patients (over 65 years), statistically significant. High rates of MDR were found for Klebsiella spp. (70.04%) and Pseudomonas aeruginosa (66.25%) while almost all of the isolated NFB strains were MDR (98.82%). The study revealed high rates of MDR pathogens in the majority of ICU isolates which may be due to unnecessary use of higher generations of antibiotics, use of mechanical devices, age, comorbidities, and can determine a higher rate of morbidity and mortality among these patients.
Evaluation of Porphyridium purpureum and Nannochloropsis sp. for Carbohydrates and Lipids Production
Authors: Oprescu Elena Emilia , Enascuta Cristina Emanuela , Galan Ana Maria , Bombos Mihaela , Vasilievici Gabriel , Isopencu Gabriela , Lavric Vasile , Velea Sanda
Published: January 2020

This study was aimed to evaluate the growth conditions of Porphyridium purpureum and Nannochloropsis sp. microalgae for carbohydrates and lipids productivity increase. The cultivation experiments for both microalgae strains were done in triplicates using the artificial seawater (ASW) as culture media. The lipids were separated from the algal biomass and the exo-polysaccharides content from the supernatant. The results showed that the highest carbohydrate content is found in Porphyridium purpureum while the highest lipid content was found in biomass.
Relation Between Clinical Oral Health Status, Oral Health Related Quality of Life, Denture Material Type and Self-perceived General Health, in a General Population
Authors: Grecu Alexandru Gratian , Aungurencei Andra Elena , Dumitrascu Dan Lucian
Published: January 2020

The purpose of the current study was to assess the oral health related quality of life (OHRQoL), general health related quality of life (HRQoL), clinical oral and denture status, as well as their interrelation, within a hospitalized general population. The Romanian versions of the Oral Health Impact Profile-49 (OHIP-49Ro), SF-36 questionnaires, together with an additional set of oral health assessment questions, were administered under the interview format to 170 patients, hospitalized in the Second Medical Clinic of Internal Medicine, Cluj-Napoca, Romania. The patients also underwent clinical examination, based on which the DMFT was calculated. Denture status, was as well, registered, together with the denture material. Each patient provided informed consent, prior to any examination. Questionnaire scores were calculated and used for the univariate descriptive statistics, reflecting oral health, OHRQoL and HRQoL sample tendencies. Successively, multiple regression analysis was applied, with the purpose of investigating the relationship between: the clinical oral health status, OHRQoL and HRQoL. In the first model, OHRQoL, while in the second model the dependent variable was represented by the HRQoL, each having a set of established predictors. Additionally, for denture wearing patients, OHRQoL variations in respect to the denture material were assessed, using one-way ANOVA. The mean OHIP-49Ro overall score was 31.90. The mean SF-36 subscales score was 60.66. The mean DMFT score was 18.47. For both regression analyses, all the regression models were significant. For the first model, the predictors accounted for 48.5% of variance in OHRQoL. For the second model, the highest percent of variance, explained by the predictors, was registered for the Mental Health subscale (22.8%). DMFT, as a clinical measure, was a statistically significant predictor rather for the perception in general health. However, OHRQoL was a good predictor for HRQoL, as an integrated part of it. Moreover, the one-way ANOVA indicated statistically significant differences in OHRQoL perception, in respect to the denture material F(2, 82) = 3.253, p = 0.044. The current study indicated complex relations between the patients� clinical status, the OHRQoL and HRQoL. The clinical determinants presented direct impact on both OHRQoL and HRQoL. More balanced HRQoL scores suggested that patients focused more on the perception of general health outcomes.
Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts
Authors: Balean Octavia Iulia , Floare Alin Daniel , Focht Roxanne , Jumanca Daniela , Coricovac Dorina , Pinzaru Iulia , Galuscan Atena , Chioran Doina , Cheveresan Adelina , Podariu Angela Codruta
Published: January 2020

Bisphosphonates are effective antiresorptive agents frequently used in the treatment of different bone disorders, as osteoporosis, Paget�s disease and tumours that cause osteolysis. A major concern related to bisphosphonates therapy is represented by osteonecrosis of jaw, a serious, debilitating, and mostly, a therapy-resistant disease, reported as a frequent side effect of bisphosphonates. The present study was aimed to assess and compare the effect of four commercially available bisphosphonates, very frequently used as oral (Fosamax - F and Actonel - A) and injectable (Ossica - O and Zoledronic acid - Z) therapy on primary human gingival fibroblasts - HGF viability. Alamar blue cell viability assay was performed to assess the effect of test compounds (1.5; 2.5; 5 and 10 mM) on gingival fibroblasts viability after a 24 h interval. In these experimental conditions, injectable bisphosphonates (O and Z) proved to be safe for HGF cells, whereas oral compounds (F and A) were cytotoxic even at low concentrations.
Preserving Fertility in Ovarian Cancer
Authors: Dinca Alexandra Ligia , Dinca Valeriu Gabi , Birla Rodica Daniela , Constantinoiu Silviu Marian
Published: January 2020

In the last decades, by improving the oncological treatment, the life expectancy of the adolescent patients with ovarian cancer has been increased and more than that they have succeeded by a real chance of obtaining a future pregnancy. Thus, the problem of preserving fertility becomes paramount both for patients who have suffered from an oncological disease and for those up to the age of 40 who have fertility problems.
Considerations Upon Pterygium Perception in Terms of Symptoms Induced by Inflammatory Response, According to Sex and Age
Authors: Mercut (Nicolcescu) Maria Filoftea , Craitoiu Stefania , Dima Alin Stefanescu , Mocanu Carmen Luminita , Tanasie Andreea , Mercut Irina , Ionescu Mihaela
Published: January 2020

Pterygium is a common eye disease, which affects both males and females, and is usually described by most patients as painless and unaesthetic. In case pterygium is symptomatic, the perceived ocular discomfort level is determined by a series of symptoms, among which we have studied tearing, foreign body sensation and blurred vision. Based on patients� evaluation, we have generated a perception score regrouping the presence or absence of symptoms, and we have analysed it according to various age decades and sex. In this study, our data revealed a correlation between the presence of the studied symptoms and the size of the lesion measured when patients opted for professional medical care (P [ 0.01). We have also determined that males and females with similar lesions in terms of size have a different perception upon pterygium; there are also differences regarding symptoms presence or absence, for various age decades and lifestyle context. In general, pterygium perception score indicated that males are more constant in their evaluation, presenting increased score values for higher ages; females tend to seek out medical treatment later than males, especially for higher ages, and present greater perception scores which do not seem to be correlated with age decades.
Primary Bowel Malignant Melanoma with Ileo-Ileal Intussusception
Authors: Firescu Dorel , Serban Cristina , Neagu Anca , Mihalache Daniela , Rebegea Laura
Published: January 2020

Primary malignant melanoma of the small bowel is extremely rare. A limited number of cases was described in the specialty literature. The small bowel is most frequently affected by metastatic tumors of other primary lesions, especially epidermal. We report the case of a 77 years old male patient with primary bowel malignant melanoma, diagnosed histologically and immunohistochemically after segmental ileal resection.
It was not discovered a primary lesion atskin, eye, anus and rectum levelor with other localization, through the investigations performed after surgery.
Clinical and Biological Profile of Patients with Non-Valvular Atrial Fibrillation and Hemodynamic Significant Valvular Heart Disease
Authors: Ardeleanu Iuliana , Floria Mariana , Badulescu Oana Viola , Bojan Iris Bararu , Vladeanu Maria , Anghel Larisa , Tanase Ana , Macovei Liviu , Statescu Cristian , Ciocoiu Manuela , Sirbu Paul Dan , Arsenescu Georgescu Catalina
Published: January 2020

The non-valvular AF, beyond the guidelines, include 2 types of patients. We aimed to analyze the clinical and biological profile of patients with non-valvular atrial fibrillation (AF)andhemodynamicsignificantvalvular heart disease. We includedretrospectively 513 patients admitted in our hospitalwithnon-valvular AF, and we divided into:study group(333 patients; 64.9%) andcontrole group(180 patients; 35.1%) hemodynamic significant valvular heart disease. From the studied group 5.5% of patients associated all four valvular heart disease, 26.7% ofpatients associated mitral, aortic and tricuspid regurgitation and 71.9%of patients associated two valvular heart disease: 32.7% with mitral and aortic, 31.4% with mitral and tricuspid, 4.5% with tricuspid and pulmonary, and3.3% withtricuspid and aortic. Dyslipidemia (higher cholesterol and trygliceride levels) was present in 14.5% of patients, statistic significantly more frequently in patients from the control group (11.4% vs 18.3%, P= 0.033). Dyslipidemia showed a significantly higher estimated risk for AF (RR=1.25; IC95%: 0.99-1.56), as well as diabetes mellitus (RR=1.36; IC95%: 1.12-1.64)and coronary heart disease (RR=3.70; IC95%: 1.83-7.46). Therefore patients with non-valvular AF and hemodynamic significant valvular heart disease, beyond the curent guidelines, could has a completely different profile and prognosis.
Electrochemical Deposition of Mixed Ce-Al Oxide Layers on Stainless Steel and Assessment of their Corrosion-Protective Ability
Authors: Guergova Desislava , Stoyanova Emilia , Avramova Ivalina , Stoychev Dimitar
Published: January 2020

The corrosion protective ability of the electrodeposited mixed nanocrystalline (CeO2)x(Al2O3)1-x layers has been studied in 0.1M HNO3 solution as a function of the changing ratio between CeO2, CeAlO3 and Al2O3 on the modified SS surface. It was ascertained that the mixed layer changes substantially the character of the cathodic corrosion reaction, which leads to changes in the control of the corrosion process and stabilization of the passive state of the SS, the system (CeO2)x(Al2O3)1-x/SS respectively, in case of prolonged corrosion testing.
Synthesis and Structural Characterization of Cobalt Nanostructures in AAO Membranes
Authors: Calin Gabriela , Mitrea Geta , Marcu Constantin , Burlui Alexandra , Trusca Roxana , Vasile Eugeniu , Iacomi Felicia
Published: January 2020

Metallic nanostructures have attracted the interest of researchers due to their fundamental importance and potential applications in nanodevices, sensors and catalysts. Co-AAO nanocomposites were obtained by using a sol-gel method that uses ultrasonic vibrations to induce the penetration of a colloidal solution through the pores of an anodized aluminum oxide (AAO) template. The AAO template, with the sol into its pores, was annealed at 648 K. The entire dip-anneal-dip�process was repeated three times. Finally, the metal nanostructures were formed by further annealing at 873 K in hydrogen atmosphere for 1 h. The morphology and structure of Co-AAO were investigated by using SEM, HRTEM, XRD and EPR methods.
FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN STRESS KERJA PERAWAT DI RUANG ICU RS STELLA MARIS MAKASSAR
Authors: Haerani  , Edison
Published: January 2020

Job stress is an important factor to consider in improving the performance and quality of goal achievement nurses in nursing care The aim of the research was to find the factors related to work stress of ICU nurses. The research was a cross sectional study. The sample consisted of 30 nurses of all population in ICU. The data were obtained using queitionaire and analized using chi squere test with contuinity correction or Yates Correction. The result of multivariate analysis was used to see the most dominant factor releted to work stress of ICU nurses. The result of the research indicate that there are 13 (43.3%) people having a slight stress and 17 (56.7%) people having a severe stress. The result of bivariate analysis between independent variable and dependent variable indicate job intrinsic factor (p=0.001), job extrinsic factor (p=0.005), and individual factor (p=0.004). the analysis of multivariate analysis indicate that intrinsic factor is the most related factor with work stress of ICU nurses. It is concluded that there is correlation between work ontrinsic factor, work extrinsic factor, individual factor and work stress ICU nurses. It is expected that the improvement of job intrinsic factor such as work load, work rutinity, and work invorenment situation could become the program in avoiding the occurrence of work stress of ICU nurses.
Konsep Prajurit Allah Berdasarkan Efesus 6:10-20 dan Implementasinya Dalam Kehidupan Orang Percaya
Authors: Kadjakoro Yolanda Olivya
Published: January 2020

A soldier of God will always be identical to his armor. God's armor itself is a picture used by the Apostle Paul in his letter to the congregation at Ephesus. Paul ended this letter to the congregation by giving a description of the weapons used by the Roman army at that time. The weapons themselves are belts, armor, shoes, shields, helmets and swords. Paul gives this picture so that his readers in Ephesus can understand that it is actually one of the Roman provinces. This weapon of God does not only apply to the Ephesians, but can also be drawn into the lives of believers, namely that the war of believers against the powers of Satan must be equipped with truth, justice, willingness, faith, the word of God, and prayer.

Seorang prajurit Allah akan selalu identik dengan perlengkapan senjatanya. Perlengkapan senjata Allah sendiri merupakan suatu gambaran yang dipakai oleh Rasul Paulus dalam suratnya kepada jemaaat di Efesus. Paulus mengakhiri suratnya ini kepada jemaat disana dengan memberikan gambaran perlengkapan senjata yang dipakai oleh tentara Romawi pada saat itu. Perlengkapan senjata itu sendiri ialah  ikat pinggang, baju zirah, kasut kaki, perisai, ketopong, dan pedang. Paulus memberikan gambaran ini agar dapat dimengerti oleh pembacanya di Efesus yang notabene adalah salah satu propinsi Romawi. Perlengkapan senjata Allah ini tidak hanya berlaku bagi jemaat di Efesus saja, tetapi juga dapat ditarik ke dalam kehidupan orang percaya yaitu bahwa peperangan orang percaya melawan kuasa-kuasa Iblis harus dilengkapi dengan kebenaran, keadilan, kerelaan, iman, firman Allah, dan doa.
Analisis Penerimaan Orang Tua Terhadap Anak Autis di Kecamatan Kelapa Lima Kota Kupang
Authors: Tameon Sance Mariana , Tlonaen Talita
Published: January 2020

Children who are born with a perfect condition in the sense of healthy and normal are expected by all parents. In reality, not all children are born with this condition, so that not a few parents who are shy, lack of confidence and unable to accept the situation of less normal children. One example is a child who has autism. The purpose of this study was to determine how parents' attitudes toward children with autism. Qualitative methods used in this study with data collection techniques are interviews and observation. The results of the study found that parents can accept children diagnosed with autism with a different time period from one another. This can be seen from how the subject understands the child's condition as it is good, positive, negative, strengths and weaknesses of the child and understands children's habits in their daily life such as realizing what children can and cannot do, understanding the causes of bad and good behavior done by children.

Anak yang terlahir dengan keadaan sempurna dalam artian sehat dan normal sangat diharapkan oleh semua orang tua. Kenyataannya, tidak semua anak terlahir dengan kondisi demikian, sehingga tidak sedikit orang tua yang malu, kurang percaya diri dan tidak dapat menerima keadaan anak yang kurang normal. Misalnya anak yang mengidap autisme. Penelitian ini  bertujuan untuk mengetahui bagaimana sikap penerimaan orang tua terhadap anak penyandang autis. Metode kualitatif dipakai dalam penelitian ini dengan teknik pengumpulan datanya adalah wawancara dan observasi. Hasil penelitian didapati bahwa orangtua dapat menerima anak yang didiagnosa menyandang autis dengan jangka waktu yang berbeda satu dengan yang lainnya. Pasangan orang tua yang lengkap (suami istri) berbeda dengan orang tua single parent dalam proses penerimaan anak autis. Hal ini terlihat dari bagaimana subjek memahami kondisi anak apa adanya baik itu tingkah laku positif, negatif, kelemahan dan kelebihan yang anak miliki, serta memahami kebiasaan-kebiasaan anak dalam kesehariannya. Seperti menyadari apa yang telah dapatdan yang belum dilakukan oleh anak dan memahami munculnya perilaku anak yang baik dan buruk.
RANCANG BANGUN PENGARSIPAN BEBAN KERJA UNTUK JENJANG JABATAN AKADEMIK DENGAN METODE RUP (STUDI KASUS PADA STMIK WIDURI)
Authors: Budiyantara Agus
Published: January 2020

Dosen adalah salah satu komponen penting didalam suatu sistem pendidikan perguruan tinggi , Karena

fungsi seorang dosen sangat penting, maka pemerintah menetapkan mengenai jabatan fungsional dosen dan

angka kreditnya yang disebut jabatan akademik. Untuk menentukan angka kredit terdapat beberapa unsur

Tri Dharma yang meliputi Pengajaran, Penelitian dan Pengabdian Masyarakat. Jabatan fungsional dosen

dibuat sebagai tanda penghargaan, pengakuan dan kepercayaan atas kinerja, integritas dan tanggung jawab

dosen. Namun permasalahan timbul ketika dosen yang akan mengurus jenjang jabatan akademik terhambat

oleh masalah administrasi. Peneliti memilih STMIK Widuri sebagai obyek penelitian karena hingga saat ini

STMIK Widuri tidak memiliki pengarsipan yang baik untuk dokumen para dosennya ketika akan mengurus

jenjang jabatan akademik, tidak adanya kejelasan untuk jalur karir dosen, informasi mengenai jenjang

jabatan akademik tidak disosialisasikan secara baik, sehingga pemahaman mengenai pentingnya jenjang

jabatan akademik tidak ketahui oleh semua dosen, tingginya tingkat ketidakhadiran dosen dalam

perkuliahan, dosen sering keluar masuk atau turn over yang berpengaruh kepada akuntabilitas perguruan

tinggi. Untuk memecahkan permasalah diatas, peneliti melakukan tinjauan pustaka, pengumpulan data yang

meliputi wawancara, observasi, analisis data dengan menggunakan RUP (Rational Unified Process),

merancang model, membangun prototype dan pengujian dilakukan dengan cara metode user acceptance

test. Dan hasil yang diharapkan dari sistem ini adalah mengatasi permasalahan mengenai kinerja dosen

untuk jenjang jabatan akademik di STMIK Widuri.
PERSEPSI DIGITAL WALLET DI INDONESIA – STUDI KASUS PADA GO-PAY
Authors: Chandra Yakob Utama
Published: January 2020

Penelitian ini dilakukan dengan menggunakan metode penelitian campuran yaitu kualitatif dan kuantitatif. Penelitian ini

dilakukan untuk menganalisis penggunaan digital wallet khususnya GO-Pay di Indonesia. Data yang digunakan

adalah data hasil penyebaran kuesioner dari masyarakat Indonesia yang telah menggunakan digital wallet khususnya

pada GO-Pay. Kesimpulan penelitian ini bahwa digital wallet merupakan alat pembayaran yang populer dan memiliki

pengguna yang banyak di seluruh dunia.
PERANCANGAN SISTEM INFORMASI AKUNTANSI SIKLUS PENGGAJIAN PADA PERUSAHAAN RETAIL
Authors: Hartono Sugiarto
Published: January 2020

Tujuan dari penelitian ini adalah untuk mengidentifikasi. menganalisis serta merancang sebuah sistem informasi akuntansi penggajian untuk mendukung proses penggajian pada perusahaan retail. Metode perancangan yang digunakan adalah metode Object Oriented Analysis and Design (OOAD) yang mengacu pada permodelan. Untuk menggali informasi mengenai proses bisnis yang berjalan, maka dilakukan beberapa tahap seperti survei, wawancara dan identifikasi masalah. Analisis dilakukan berdasarkan proses penggajian yang saat ini berjalan , selanjutnya hasil analisis dituangkan dalam perancangan sistem informasi akuntasi penggajian berupa aplikasi web yang dapat membantu kegiatan absensi, izin/cuti, lembur, pinjaman dan penggajian, khususnya pendokumentasian dan penyimpanan data yang terintegrasi sehingga membantu mempercepat proses perhitungan gaji karyawan.
PERENCANAAN BISNIS ERPIN.BIZ SEBAGAI APLIKASI ERP FINANCIAL BERBASIS CLOUD COMPUTING UNTUK USAHA MIKRO, KECIL DAN MENENGAH
Authors: Natanael Seprihadi
Published: January 2020

Tujuan dari penelitian ini adalah untuk menganalisa peluang dan kelayakan bisnis solusi ERP Financial berbasis cloud computing untuk Usaha Mikro, Kecil, dan Menengah di Indonesia. Perencanaan bisnis ini disusun berdasarkan hasil dari pembuatan analisa SWOT, strategi pemasaran, model bisnis, dan melakukan penilaian bisnis. Dapat disimpulkan bahwa bisnis ini layak dijalankan dilihat dari Return on-Investment (ROI) sebesar 438,43% setelah jangka waktu 2,5 tahun.
PENGEMBANGAN SISTEM INFORMASI JASA PENUKARAN VALAS
Authors: Perbangsa Anzaludin Samsinga , Reyner Aloysius , Nugroho Joshua Christian , J Junne
Published: January 2020

Peran money changer sangat penting dalam memenuhi kebutuhan valas untuk masyarakat. Peran tersebut juga dapat dipenuhi oleh bank dan institusi keuangan lainnya. Masyarakat yang hendak memesan mata uang asing saat ini masih harus melalui prosedur tradisional, dimana pemesan diharuskan untuk datang secara langsung ke tempat penukaran valuta asing. Penelitian ini bermaksud untuk membangun rancangan sistem yang dapat melakukan pemesanan mata uang dan memberikan informasi kurs mata uang asing yang terdapat pada setiap money changer melalui aplikasi berbasis web. Penelitian ini menggunakan metode Object Oriented Analysis and Design (OOAD), studi pustaka, dan metode pengumpulan data menggunakan kuesioner. Berdasarkan masalah yang dijabarkan dan hasil penelitian, maka sistem ini dapat menjadi sumber informasi pertukaran kurs valuta asing dan juga menjadi alternatif pemesanan valuta asing. Sehingga pengguna dapat mencari nilai valas dan memesannya secara mudah melalui media online.
KOMPARASI METODE INTERPOLASI UNTUK SISTEM PENGENALAN SEL DARAH PUTIH
Authors: L Lina , Anthony Kelly
Published: January 2020

Sistem aplikasi yang dirancang bertujuan untuk membantu ahli dalam bidang medis untuk mendiagnosis penyakit melalui pengenalan terhadap jenis sel darah putih. Sistem pengenalan yang dikembangkan menggunakan metode Nearest Feature Line (NFL). Dalam metode NFL ini, garis ciri dibentuk menggunakan metode interpolasi linier, spline linier, spline kuadratik, dan spline kubik. Selain melakukan sistem pengenalan, makalah ini juga membahas perbandingan antara metode interpolasi untuk membentuk garis ciri. Pengujian dilakukan dengan menggunakan data sel darah laboratorium Pattern Recognition FTI Untar. Hasil pengujian menunjukkan bahwa pembentukan garis ciri menggunakan metode interpolasi linier memberikan hasil pengenalan yang lebih baik dibandingkan dengan metode interpolasi spline.
PRE-ELIMINARY STUDY OF IKAN (FISH ONLINE INVESTMENT) PROTOPY BASED ON WEB APPLICATION USING AGILE SCRUM
Authors: Sari Wina Permana , Sidharta Hanugra Aulia , A Sidharta
Published: January 2020

Departemen Kesehatan (DepKes) Republik Indonesia, masalah utama yang seringkali menjadi penghambat bagi nelayan dalam membuka suatu usaha kecil dalam bidang perikanan ialah masalah permodalan. Masalah permodalan tersebut dapat dijabarkan menjadi: sulitnya akses, persyaratan penerimaan permodalan yang berbelit-belit, hingga ketidaktahuan masyarakat mengenai lembaga pendanaan. Akibatnya, tak sedikit masyarakat yang kemudian menggunakan modal mandiri, ataupun melakukan peminjaman melalui lembaga keuangan yang informal. Masalah yang didapatkan para nelayan tersebut seringkali membuat mereka bingung dan bahkan kesusahan saat membuka usaha mikro mereka tersebut. Namun, hal tersebut tentu dapat diatasi, mengingat bagaimana teknologi sudah berkembang pesat saat ini. Dari segi perkembangan teknologi, saat ini kita memasuki era revolusi industri 4.0, dimana teknologi informasi dan informasi sudah sangat berkembang. Melihat fakta yang ada di masyarakat, teknologi dapat digunakan untuk mempermudah manusia dalam melakukan kegiatan sehari-hari. Oleh karena itu, menilik fakta-fakta diatas, maka penulis ingin menciptakan sebuah aplikasi investasi perikanan sebagai wadah bagi para investor untuk menanamkan modal mereka didalam usaha mikro para nelayan, dan sebaliknya. Penulis ingin menciptakan aplikasi Investasi Perikanan berbasis mobile dan web (dengan menggunakan bootstrap) yang akan penulis namai “Ikan” yang diambil dari Investasi perikanan secara bertahap menggunakan tahapan-tahapan yang sesuai dalam metode Agile Scrum yang berbasis pada pengetahuan di dalam bidang Software Engineering dan dilengkapi dengan model-model rancangan dasar untuk pembentukkan sistem, seperti: Business Model Canvas (BMC), Use Case, Activity Diagram, dan mock-up.
PERANCANGAN SISTEM INFORMASI MARKETING BERBASIS WEBSITE PADA
Authors: Hartono Sugiharto
Published: January 2020

Tujuan penelitian ialah merancang dan menghasilkan sebuah aplikasi berbasis web yang mempermudah PT. SBM dan perusahaan lain maupun perorangan untuk mempromosikan produk-produknya kepada khalayak ramai. Permasalahan umum pada PT. SBM adalah terbatasnya dana serta sumber daya untuk mempromosikan suatu produk. Karena itu, diperlukan sebuah website yang dapat membantu memperkenalkan atau mempromosikan produk-produk yang akan dijual kepada khalayak ramai tanpa memandang jarak dan waktu, serta menghemat biaya promosi. Metode penelitian yang digunakan yaitu metode pengumpulan data melalui survei, wawancara, dan studi kepustakaan. Metode perancangan aplikasi menggunakan metode OOAD yang dibagi menjadi 2 proses: Analisis dan Perancangan. Hasil penelitian berupa web yang dapat mempromosikan produk-produk perusahaan maupun perorangan secara lebih efektif dan efisien. Simpulan dari penelitian ini ialah dihasilkannya e-marketing berbasis web yang dapat mendukung perusahaan maupun perorangan dalam mempromosikan produk-produknya.
PERANCANGAN APLIKASI BERBASIS ANDROID UNTUK KOMUNITAS PENGGEMAR BURUNG KICAU
Authors: Dian sano Albert V , Muhammad Bintang Fadhli , Mangare Edward Kristian , Jason Jeremy , Hidayah Taufiq
Published: January 2020

Tujuan dari kajian ini adalah merancang aplikasi berbasis android untuk komunitas penggermar burung. Kicau adalah forum berbasis android untuk komunitas pecinta burung. Penerapan teknologi Android pada informasi tentang kegiatan komunitas kicau burung adalah aplikasi yang berfungsi untuk memberikan informasi yang efektif bagi anggota komunitas kicau mania di berbagai acara, kompetisi dan jual beli burung. Dalam aplikasi ini pengguna dapat memposting foto dari burung, transaksi jual beli burung. lihat informasi berita dan jadwal balapan serta tip tentang perawatan burung agar siap bersaing. Aplikasi ini dibangun menggunakan Android Studio dan menggunakan metode desain Business Model Canvas (BMC), Use Case, Activity Diagram, dan mock-up.