bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasensitive wearable pressure sensors based on Silver nanowire-coated fabrics
Authors: Lian Yunlu , Yu He , Wang Mingyuan , Yang Xiaonan , Zhang Hefei
Published: February 2020

Flexible pressure sensors have attracted increasing attention due to their potential applications in wearable human health monitoring and care systems. Herein, we present a facile approach for fabricating all-textile-based piezoresistive pressure sensor with integrated Ag nanowire-coated fabrics. It fully takes advantage of the synergistic effect of the fiber/yarn/fabric multi-level contacts, leading to the ultrahigh sensitivity of 3.24×10 5 kPa −1 at 0–10 kPa and 2.16×10 4 kPa −1 at 10–100 kPa, respectively. Furthermore, the device achieved a fast response/relaxation time (32/24 ms), and a high stability (>1000 loading/unloading cycles). Thus, such all-textile pressure sensor with high performance is expected to be applicable in the fields of smart cloths, activity monitoring and healthcare device.
Impact of coronary collateralization on long-term clinical outcomes in type 2 diabetic patients after successful recanalization of chronic total occlusion
Authors: Yang Zhen Kun , Shen Ying , Dai Yang , Wang Xiao Qun , Hu Jian , Ding Feng Hua , Zhang Rui Yan , Lu Lin , Shen Wei Feng
Published: February 2020

Background: To assess the prognostic role of coronary collaterals in patients with type 2 diabetes mellitus (T2DM) after successful percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Methods: Coronary collateralization was graded according to Rentrop scoring system in 198 type 2 diabetic patients and 335 non-diabetics with stable angina undergoing PCI for at least one CTO lesion. Left ventricular ejection fraction (LVEF) was determined and major adverse cardio-cerebral events (MACCE) were recorded during follow-up. Results: Poor collateralization was more common in patients with T2DM than in non-diabetics (40% vs 29%, p=0.008). At 13.5±4.1 months, the rate of composite MACCE (17.3% vs 27.6%, p=0.034) and repeat revascularization (15.2% vs 25.5%, p=0.026) was lower and the increase in LVEF (3.10 % vs 1.80%, p=0.024) was greater in patients with good collaterals than in those with poor collaterals for non-diabetic group, but did not differ for T2DM group (35% vs 44%; 30% vs 36%; 2.14% vs 1.65%, respectively, all p>0.05) except for a higher all-cause mortality in diabetic patients with poor collaterals (p=0.034). Multivariable Cox proportional hazards analysis showed that coronary collateralization was an independent factor for time to MACCE (HR 2.155，95%CI 1.290-3.599, P=0.003) and repeat revascularization (HR 2.326, 95%CI 1.357-3.986, p=0.002) in non-diabetic patients, but did not enter the model in those with T2DM. Conclusions: T2DM is associated with reduced coronary collateralization. Successful revascularization of CTO lesions results in a mild improvement in left ventricular function, but t he status of coronary collaterals has no independent effect on long-term clinical outcomes in patients with T2DM.
Centrilobular zonal necrosis is a unique subtype of autoimmune hepatitis A cohort study
Authors: Ueda Kaoru , Aizawa Yoshio , Kinoshita Chika , Nagano Tomohisa , Ishida Jinya , Saeki Chisato , Oikawa Tsunekazu , Harada Toru , Hokari Atsushi , Saruta Masayuki
Published: February 2020

BACKGROUND Centrilobular zonal necrosis (CZN) is advocated as a histological hallmark present in a small number of patients with autoimmune hepatitis (CZN-AIH). Moreover, CZN has been detected in the absence of significant interface hepatitis, one of the most important histological findings of AIH. The concept of CZN-AIH as a distinctive subtype of AIH remains controversial, due to the rarity of CZN-AIH and the ambiguous definition of CZN. To elucidate the clinicopathological and immunogenetic features of CZN-AIH, and to evaluate the significance of co-existent interface hepatitis in CZN-AIH. METHODS A total of 102 biopsy samples of AIH, obtained at The Jikei University Katsushika Medical Center and Jikei University Hospital, were reviewed. The 32 patients whose biopsies showed CZN were selected as the CZN-AIH group and the remaining 70 were grouped as the non-CZN-AIH controls. In the CZN-AIH group, interface hepatitis was histologically present in 37.5% (n=12; mixed-type) and absent in 62.5% (n=20; pure-type). Data on clinical, histopathologic and immunogenetic features were statistically compared between the CZN-AIH group and the non-CZH-AIH controls. Additionally, significance of interface hepatitis in CZN-AIH was determined by comparative analysis of the mixed-type and pure-type subgroups. RESULTS Cases of CZN-AIH were more frequently of acute-onset hepatitis (56.2% vs chronic: 32.9%, P=0.031), lower immunoglobulin G level (P<0.001), lower antinuclear antibodies titer (P<0.001), and lower AIH score (P<0.001). Compared to the non-CZN-AIH cases, the CZN-AIH cases also tended to lack the typical histological characteristics of AIH and of the immunogenetic disproportionate distribution of HLA-DR genotypes in AIH (increased HLA-DR4 and decreased HLA-DR9), and responded more favorably to first-line therapy (P=0.054). For the acute-onset CZN-AIH cases, the clinical and histological features were indistinguishable from the non-acute cases. In contrast, the acute-onset non-CZN-AIH cases were distinguishable from the non-acute cases by lower antinuclear antibodies titer, lower immunoglobulin G level, and less advanced histological stage. The presence of interface hepatitis generally did not influence the morbidity of CZN-AIH, except for comorbid autoimmune diseases, higher gamma-glutamyltranspeptidase level, and increased immunoglobulin M level. CONCLUSION CZN-AIH is clinicopathologically and immunogenetically distinguishable. CZN can characterize a distinct AIH subtype, regardless of onset-pattern or co-existent interface hepatitis.
Distribution of Anopheles species in malaria endemic areas of Honduras in an elimination setting
Authors: Escobar Denis , Ascencio Krisnaya , Ortiz Andrés , Palma Adalid , Fontecha Gustavo
Published: February 2020

Background: Anopheles mosquitoes are the vectors of malaria, one of the most important infectious diseases in the tropics. More than 500 Anopheles species have been described worldwide, and more than 30 are considered a public health problem. In Honduras, information on the distribution of Anopheles spp. and its genetic diversity is scarce. This study aimed to update information on the diversity of Anopheles mosquitoes in Honduras with a morphological and molecular approach. Methods: Mosquitoes were captured in 8 locations in 5 malaria endemic departments during 2019. Two collections methods were used. Adult anophelines were captured outdoors using CDC light traps and by aspiration of mosquitoes at rest. The morphological identification was performed using taxonomic keys. Genetic analyses included the sequencing of a partial region of the cytochrome oxidase I gene (COI) and the ribosomal internal transcribed spacer 2 (ITS2). Results: A total of 1320 anophelines were collected and identified through morphological keys. Seven Anopheles species were identified. An. albimanus was the most widespread and abundant species (74.02%). To confirm the morphological identification of the specimens, 175 and 122 sequences were obtained for COI and ITS2 respectively. Both markers confirmed the morphological identification. COI showed a greater nucleotide diversity than ITS2 in all species. High genetic diversity was observed within the populations of An. albimanus while An. darlingi proved to be a highly homogeneous population. Phylogenetic analyses revealed clustering patterns in An. darlingi and An. neivai in relation to specimens from South America. New sequences for An. crucians, An. vestitipennis, and An. neivai are reported in this study. Conclusions: Here we report the distribution of Anopheles species in endemic areas of malaria in Honduras. According to our results, both taxonomic and molecular approaches are useful tools in the identification of anopheline mosquitoes. However, both molecular markers differ in their ability to detect intraspecific genetic diversity. These results provide supporting data for a better understanding of the distribution of malaria vectors in Honduras.
­Rotavirus group A genotype circulation patterns across Kenya before and after nationwide vaccine introduction, 2010-2018
Authors: Mwanga Mike , Owor Betty , Ocheing John , Ngama Mwanajuma , Ogwel Billy , Onyango Clayton , Juma Jane , Njeru Regina , Gicheru Elijah , Otieno Grieven , Khagayi Sammy , Agoti Charles , Bigogo Godfrey , Omore Richard , Addo Yaw , Mapaseka Seheri , Tate Jacqueline , Parashar Umesh , Hunsperger Elizabeth , Verani Jennifer , Breiman Robert , Nokes James
Published: February 2020

Background: Kenya introduced the monovalent G1P[8] Rotarix® vaccine into the infant immunization schedule in July 2014. We examined trends in rotavirus group A (RVA) genotype distribution pre- (January 2010 - June 2014) and post- (July 2014-December 2018) RVA vaccine introduction.Methods: Stool samples were collected from children aged <13 years from four surveillance sites across Kenya: Kilifi County Hospital, Tabitha Clinic, Lwak Mission Hospital, and Siaya County Referral Hospital (children aged <5 years only). Samples were screened for RVA using enzyme linked immunosorbent assay (ELISA) and G and P genes sequenced to infer genotypes.Results: We genotyped 614 samples in pre-vaccine and 261 in post-vaccine introduction periods. During the pre-vaccine introduction period, the most frequent RVA genotypes were G1P[8] (45.8%), G8P[4] (15.8%), G9P[8] (13.2%), G2P[4] (7.0%) and G3P[6] (3.1%). In the post-vaccine introduction period, the most frequent genotypes were G1P[8] (52.1%), G2P[4] (20.7%) and G3P[8] (16.1%). Predominant genotypes varied by year and site in both pre and post-vaccine periods. Temporal genotype patterns showed an increase in prevalence of heterotypic commonly DS-1-like G2P[4] (7.0 to 20.7%, P <.001) and G3P[8] (1.3 to 16.1%, P< .001) genotypes in the post-vaccine introduction period. Additionally, we observed a decline in prevalence of genotypes G8P[4] (15.8 to 0.4%, P <.001) and G9P[8] (13.2 to 5.4%, P <.001) in the post-vaccine introduction period.Conclusion: Genotype prevalence varied from before to after vaccine introduction. Such observations emphasize the need for long-term surveillance to monitor vaccine impact. These changes may represent natural secular variation or possible immuno-epidemiological changes arising from the introduction of the vaccine. Full length sequencing could provide insights into post-vaccine evolutionary pressures and antigenic diversity.
Changes in choroidal thickness in advanced diabetic retinopathy treated with pan-retinal photocoagulation using a pattern scanning laser versus a conventional laser
Authors: Park Nari , Lee In Gul , Kim Jee Taek
Published: February 2020

Background : To compare the effect of pan-retinal photocoagulation (PRP) using pattern scanning or conventional laser on subfoveal choroidal thickness (SFChT).
Methods : Thirty-eight patients (64 eyes) with advanced diabetic retinopathy (DR) who underwent PRP using pattern scanning or conventional laser were included. Changes in SFChT were compared with baseline values at 1, 3, 6, and 12 months after PRP using swept-source optical coherence tomography.
Results : The conventional laser group showed statistically significant decrease in SFChT at 1, 3, 6, and 12 months after PRP ( P <0.001). SFChT was significantly decreased at 3 ( P = 0.025), 6 ( P = 0.004), and 12 months ( P < 0.001) after treatment in the pattern laser group.
Conclusion : Eyes with advanced DR showed a significant reduction in SFChT over 12 months regardless of the type of laser used; however, the reduction was sooner after conventional laser than after pattern laser.
Tracing the Decisions That Shaped the Development of MyChart, an Electronic Patient Portal in Alberta, Canada: Historical Research Study
Authors: Avdagovska Melita , Stafinski Tania , Ballermann Mark , Menon Devidas , Olson Karin , Paul Pauline
Published: February 2020

Background

Understanding how health organizations decide on information technology (IT) investments is imperative to ensure successful implementation and adoption. There is a high rate of failure and a tendency to downplay the complexity of implementation progression. Alberta Health Services introduced a patient portal called MyChart. Although MyChart allows patients to view appointments and selected laboratory results and to communicate with their providers, its uptake varies.

Objective

The study aimed to examine the institutional decision-making processes that shaped the development and implementation of MyChart.

Methods

A historical study was conducted based on the 7-step framework, where one engages in a rigorous archival critical analysis (including internal and external criticism) of documents and analysis of interviews. We reviewed and analyzed 423 primary and secondary sources and interviewed 10 key decision makers.

Results

Supportive leadership, project management, focused scope, appropriate technology and vendor selection, and quick decision making were some of the facilitators that allowed for the growth of proof of concept. The planning and implementation stages did not depend much on the technology itself but on the various actors who influenced the implementation by exerting power. The main barriers were lack of awareness about the technology, proper training, buy-in from diverse system leaders, and centralized government decision making.

Conclusions

Organizational priorities and decision-making tactics influence IT investments, implementation, adoption, and outcomes. Future research could focus on improving the applicability of needs assessments and funding decisions to health care scenarios.
Involvement of People With Dementia in the Development of Technology-Based Interventions: Narrative Synthesis Review and Best Practice Guidelines
Authors: Rai Harleen Kaur , Cavalcanti Barroso Aline , Yates Lauren , Schneider Justine , Orrell Martin
Published: February 2020

Background

Technology can be helpful in supporting people with dementia in their daily lives. However, people with dementia are often not fully involved in the development process of new technology. This lack of involvement of people with dementia in developing technology-based interventions can lead to the implementation of faulty and less suitable technology.

Objective

This systematic review aims to evaluate current approaches and create best practice guidelines for involving people with dementia in developing technology-based interventions.

Methods

A systematic search was conducted in January 2019 in the following databases: EMBASE (Excerpta Medica database), PsycINFO, MEDLINE (Medical Literature Analysis and Retrieval System Online), CINAHL (Cumulated Index to Nursing and Allied Health Literature), and Web of Science. The search strategy included search terms in 3 categories: dementia, technology, and involvement in development. Narrative synthesis wove the evidence together in a structured approach.

Results

A total of 21 studies met the inclusion criteria. Most studies involved people with dementia in a single phase, such as development (n=10), feasibility and piloting (n=7), or evaluation (n=1). Only 3 studies described involvement in multiple phases. Frequently used methods for assessing involvement included focus groups, interviews, observations, and user tests.

Conclusions

Most studies concluded that it was both necessary and feasible to involve people with dementia, which can be optimized by having the right prerequisites in place, ensuring that technology meets standards of reliability and stability, and providing a positive research experience for participants. Best practice guidelines for the involvement of people with dementia in developing technology-based interventions are described.
Research on thermal design control and optimization of relay protection and automation equipment
Authors: Suo Na , Guo Lina
Published: February 2020

Relay protection devices and power automation systems are an important product in the power equipment manufacturing industry. They are customarily divided into secondary equipment for the transmission and distribution industry, and are responsible for protecting and controlling the primary equipment of the power grid and measuring the load of the power grid system. Thermal design is a major research topic for the reliability study of relay protection devices. The paper introduces the thermal design process of the relay protection device processing equipment, from the single-chip, module level, etc. to construct and isolate the airway facilities, and uses the FLOTHERM software to simulate the relay protection device model. Thermal simulation can guide the structural design, optimize the structure, make the single-machine structure more reasonable, and the heat dissipation more effective, improving the reliability of the single machine.
The development of Kolb Learning Style and 4c's 21st century skill integration e-book in Pedagogy Subject
Authors: Santika Tiara , Ganefri Ganefri , Jalinus Nizwardi , Syahril Syahril , Rizal Fahmi , Sukardi Sukardi , Rispendra Rispendra , Nabawi Rahmat Azis
Published: February 2020

This research was based on the demands of the 21st century in which teachers should have 4 skills (critical thinking, creativity, collaboration, and communication).  Teachers are required to change the way of teaching that initially (teacher-centered) turns into (student-centered) and able to participate to follow the development of technology. Therefore,  E-book learning is needed that can present material pedagogy integrated with kolb learning and 4C's. This research aims to produce the final product in the form of valid e-book media learning, practical and effective in pedagogy subject. This was a research and development (Research and Development) research. This development research used ADDIE development model consisting of 5 stages which were Analysis, Design, Development, Implementation and Evaluation). Based on the results, e-book validation testing conducted by three validators, it obtained Aiken's score 0.9 with a valid category. The test results practicalities of the teachers and the students were 86% in the practical category. The effectiveness test results was 89.65%. Thus, it can be concluded that this research has produced a pedagogical e-book which is valid, practical and effective.
NOTED: Dreaded word culture 'like a newsroom hand grenade'
Authors: Mulrennan Danni , Robie David
Published: February 2020

They try everything, to gnaw at us, to drain us,' said the Haitaian broadcst journalist Jean Dominique. He was an enormously popular 'Mr truth' to his grassroots listeners. 'It's been going on for 50 years, and why should it stop? 'They can still try to crush us; to machinegun us; to ignore, slander bully and seduce is; to deflate, empty and distort us.'
Ben Bohane's portrayal of spirit and war in Melanesia
Authors: Bohane Ben , Dean Bec
Published: February 2020

As a photojournalist, writer and producer of television documentaries, Ben Bohane has spent the past 12 years posting stories about life on the islands of Melanesia to the Western media—illuminating the struggles and the spirit worlds behind the news. Melanesia is as close to Australia as a 150km cruise from the tip of Cape York across the Torres Strait to Papua New Guinea, connecting Australasia to the rest of Oceania and Asia. Until recently, though, these islands have seemed distantly removed from Australia and New Zealand’s notion of its international community.
Analisis Kualitas Website Perpustakaan Universitas X Menggunakan Metode Webqual 4.0 dan Importance-Performance Analysis (IPA)
Authors: Andre Yulius , Tileng Kartika Gianina
Published: February 2020

Penggunaan teknologi yakni website menjadi salah satu faktor pendukung dalam menunjang sebuah institusi. Keberadaan website juga dapat mendukung sebuah kegiatan operasional institusi pendidikan. Hal ini yang membuat peneliti ingin melakukan penelitian pada website perpustakaan Universitas X. Tujuan dari penelitian ini adalah untuk mengetahui kualitas dari website perpustakaan dimana sebelumnya belum pernah dilakukan analisis dan pengukuran dalam menilai kualitas dari website perpustakaan Universitas X. Metode yang digunakan dalam penelitian ini adalah metode WebQual 4.0 dan Importance-Performance Analysis (IPA). Variabel yang digunakan dalam penelitian ini adalah Kegunaan (Usability), Kualitas Layanan Informasi (Information Quality), dan Kualitas Layanan Interaksi (Service Interaction Quality) berdasarkan metode WebQual 4.0 dengan 22 item atribut. Hasil yang didapatkan dari analisis kualitas website memiliki tingkat kesesuaian 99.2% dimana responden merasa mendekati kepuasan terhadap pelayanan website. Tingkat Kesenjangan diperoleh -1.21 dimana hasil dari kinerja website belum sesuai dengan harapan dari pengguna. Hasil analisis kuadran pada atribut yang menjadi prioritas utama didapatkan 2 atribut yaitu website memiliki tampilan yang menarik (US5) dan pengguna merasa data pribadinya aman saat login di website (KL3).
Implikasi Erupsi Gunung Agung Terhadap Usaha Pariwisata Di Daya Tarik Wisata Bahari Tulamben, Kecamatan Kubu, Kabupaten Karangasem
Authors: Putri Ida Ayu Karina , Adikampana I Made
Published: February 2020

Tulamben Marine Tourist Attraction it has a variety of tourism business such as, tourist accommodations, diving and snorkeling occupations, porter professions also food and beverage services. Mount Agung status alert, on October 22nd, 2017 some residents within radius of 12 km are evacuated to several areas in Bali. The evacuated people are living in 28 villages in Karangasem regency, one of them is Tulamben Village. Mount Agung eruption has a direct impact on tourism bussiness. This study aims to analyze the implication of Mount Agung Eruption on Tourism Business at Tulamben Marine Attraction, Kubu Sub-District, Karangasem Regency. The research method used is qualitative study with descriptive analysis technique to examine the implications of Mount Agung eruption on tourism business. Source data from primary knowledges and secondary documents. Data are collected through observation methods, interviews, literature study, and research instruments in the form of interview guidelines. The informants are determinated by using purposive sampling technique to obtain accurate data about the type of tourism business and the implications of eruption of Mount Agung to the tourism business service in Tulamben Marine Tourist Attraction.

Keywords: Marine Tourist Atrraction, Eruption, and Tourism Bussines
Analisis Peran Stakeholder Desa Wisata Carangsari, Kecamatan Petang, Kabupaten Badung
Authors: Cahyana Shafa Raya , Nugroho Saptono
Published: February 2020

Carangsari tourism Village is one of the tourist villages in Badung Regency, with various natural and cultural potentials. This study aims to determine the role of the three pillars of tourism in carrying out its right and responsibilitiestowards of Carangsari Tourism Village.The metode used in this study is a qualitative method with qualitative descriptive techniques understand the role of stakeholders in Carangsari Tourism Village, Petang District, Badung Regency. Used some sources of data including primary data and secondary data. The collection data technique, in this study, is using observation, interviews, library studies, and several interviewguidance instrument. Determination of informant in the study of the role of stakeholder in Carangsari Tourism Village used purposive sampling to obtain accurate data on the role of three tourism pillar actor on management in Carangsari Tourism Village, Petang District, Badung Regency. The results of this study obtained the active aspectf, status, right, and

obligation Carangsari Tourism Village, Petang District, Badung Regency.Keywords: Stakeholder, Role, Village Tourism, and Badung.
ANALISIS RISIKO PAJANAN NH3 DAN H2S TERHADAP GANGGUAN PERNAPASAN PADA PENDUDUK DI SEKITAR TEMPAT PEMBUANGAN AKHIR SAMPAH BUKIT PINANG SAMARINDA
Authors: Firdaus Ade Rahmat
Published: February 2020

The air pollution in the garbage dump gave the bad effect for the environmental health , NH3, H2S and the other polluted gases were the causes of air pollution that could give the bad effect for health, especially respiratory disorders. The garbage dump of bukit pinang was located in samarinda and still used open dumping method that could cause environmental pollution. Research design used cross sectional approach. The sample of NH3 and H2S was taken at 3 points and there were 34 respondents that were chosen using purposive sampling. Data collection included in the measurement of NH3 and H2S, interview, and observation of respiratory disorders. Data analysis used t-independent test with 95% of confidence level.Result of the study showed that the concentration of NH3 and H2S at garbage dump of Bukit Pinang at sample points I, II, and III was still under quality standard. Result of T - Independent showed that there was relationship among concentration of NH3 (?-value= 0,005), concentration H2S (?-value=0,042), exposure period of NH3 and H2S (?-value=0,000), and Risk Quotient NH3 (?-value=0,000), H2S (?-value=0,000) with the respiratory disorders of the people around the garbage dump of  bukit pinang. Result of Mann-Whitney test showed that there was no relationship between exposure frequency of NH3 and H2S (?-value=0,284) with the respiratory disorders of the people around the garbage dump of bukit pinang
ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KUNJUNGAN NEONATAL DI PUSKESMAS KAMPUNG BAQA SAMARINDA TAHUN 2018
Authors: Salasiah Siti
Published: February 2020

At the age of less than 28 days newborns are very span to death, so at this time need to be aware of some signs and dangers in the newborn. One of the efforts undertaken to reduce the infant mortality rate is neonatal visits conducted in health services. This study aims to determine several factors related to Neonatal Visits (KN) in the work area of Puskesmas Kampung Baqa in 2018. This study uses Analytical Survey, with cross sectional approach. Respondents of this study were all mothers who had babies aged 0-28 days as many as 87 respondents with sampling techniques using puposive sampling. Data analysis performed was univariate and bivariate with Chi-Square test. The results of this study found that all the variables studied were associated with neonatal visits in the work area of Puskesmas Kampung Baqa in 2018, namely knowledge (p value 0,000), attitude (p value 0,000) and family support (p value 0,006). The conclusion in this research is that knowledge, attitude, and support of mother's family can influence visit of neonatal mother to conduct Neonatal Visit (KN). Therefore, it is necessary to be counseled about the importance of conducting neonatal visits to the public by health workers intensively so that the knowledge of the community especially the mothers who have babies 0-28 days to increase. Keywords : Visit Neonatal, Knowledge, Attitude, Family SupportBibliograpy : 25 (1991-2017).
Analisis Stagnant Obat Di Unit Logistik Puskesmas Sempaja Kota Samarinda Tahun 2018
Authors: Triana Ananda , Artini Ni Nyoman , Farjam Herry
Published: February 2020

Latar Belakang:Logistik obat termasuk salah satu aspek penting dalam bidang kesehatan. Stagnant obat merupakan salah satu dampak dari kurang berjalannya manajemen logistik obat dipelayanan kesehatan yaitu puskesmas. Puskesmas Sempaja Samarinda belum menjalankan manajemen logistik dengan baik. Hal ini dapat dilihat dari data obat yang mengalami kejadian stagnant sebanyak 36 jenis dari tahun 2015 hingga bulan Agustus tahun 2018.Tujuan :Penelitian ini bertujuan untuk mengetahui kejadian stagnant obat di unit logistik Puskesmas Sempaja Samarinda.Metode Penelitian:Penelitian ini merupakan kualitatif dengan pendekatan studi kasus. Sumber informasi didapatkan dari petugas pengelola obat di Unit Logistik Puskesmas Sempaja Samarinda, Kepala Puskesma Sempaja dan Kepala Tata Usaha Puskesmas Sempaja Samarinda. Teknik analisis data adalah analisis kualitatif yaitu pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan.Hasil : Hasil penelitian yang didapat adalah perencanaan yang belum tepat, penerimaan yang masih belum efektif dan penyimpanan yang baik serta pemeliharaan obat yang cukup baik. Namun walaupun didalam pemeliharaan obat telah berjalan dengan baik, peneliti menemukan bagian pemusnahan yang masih belum berjalan dengan lancar.Kesimpulan: Kesimpulan yang didapatkan dari penelitian ini adalah masih belum terlaksnanya sistem manajemen logistik dengan benar sehingga menyebabkan kejadian obat stagnant di Unit Logistik Puskesmas Sempaja Kota Samarinda Kalimantan Timur. Saran yang dapat diberikan yaitu dengan menerapkan metode yang sesuai pada setiap proses manajemen logistik.
Position of the European Court on the Implementation of Decisions by National Courts in Latvia and in Finland which are in Legal Force
Authors: Jilkine Vladimir
Published: February 2020

Legal scholar and practising lawyer from Finland Vladimir Jilkine, who recently defended his thesis with confidence, acquiring the doctoral degree in Law, in a comparative study describes European Court of Human Rights judgments and the conclusions on the implementation of national court rulings having come into force in Latvia and Finland. European Court of Human Rights judgements prove that both in Latvia, as well as in the country recognised for its democratic values, legal norm interpretations which are contrary to the international legal norms still exist. The Latvian Supreme Court and Finnish Republic Supreme Court jurisdiction state that the European Convention is recognised as essential and important legal instrument to be taken into account when dealing with specific cases.

Tiesību zinātnieks un praktizējošs jurists no Somijas Vladimirs Žilkins, kurš nesen pārliecinoši aizstāvēja promocijas darbu, iegūstot tiesību zinātņu doktora grādu, salīdzinošā pētījumā apskata Eiropas Cilvēktiesību tiesas spriedumus un atziņas par spēkā stājušos nacionālo tiesu nolēmumu izpildi Latvijā un Somijā. Eiropas Cilvēktiesību tiesas spriedumi liecina, ka gan Latvijā, gan arī valstī ar atzītām demokrātiskām vērtībām – Somijā – ir tiesisko normu interpretācijas, kuras ir pretrunā ar starptautisko tiesisko regulējumu. Latvijas Republikas Augstākās tiesas un Somijas Republikas Augstākās tiesas judikatūra liecina, ka Eiropas Konvencija uzskatāma par būtisku un nozīmīgu juridisku instrumentu, kas jāņem vērā, izskatot konkrētās lietas.
Detection of Anomalies in the Computer Network Behaviour
Authors: Protić Danijela , Stanković Miomir
Published: February 2020

The goal of anomaly-based intrusion detection is to build a system which monitors computer network behaviour and generates alerts if either a known attack or an anomaly is detected. Anomaly-based intrusion detection system detects intrusions based on a reference model which identifies normal behaviour of the computer network and flags an anomaly. Basic challenges in anomaly-based detection are difficulties to identify a ‘normal’ network behaviour and complexity of the dataset needed to train the intrusion detection system. Supervised machine learning can be used to train the binary classifiers in order to recognize the notion of normality. In this paper we present an algorithm for feature selection and instances normalization which reduces the Kyoto 2006+ dataset in order to increase accuracy and decrease time for training, testing and validating intrusion detection systems based on five models: k-Nearest Neighbour (k-NN), weighted k-NN (wk-NN), Support Vector Machine (SVM), Decision Tree, and Feedforward Neural Network (FNN).
Transition Energy, Orientation Force and Work Done in Transitional Behavior Atoms: Formulating New Principles in Thermodynamics
Authors: Ali Mubarak
Published: February 2020

A study of different parameters in thermodynamics is important for sustainable science behind various physical and chemical phenomena. This study finds an anomaly associated with the first law of thermodynamics. The anomaly is resolved for the equations of change in the internal energy of a system composed of atoms. A gas atom involves transitional energy gained to undertake transition state. Hence, the work is carried out by that gas atom. This can be registered symbolically in a plus form. A solid atom involves transitional energy absorbed in undertaking transition state. Hence, the work is carried out on that solid atom, which can be registered in a minus form. At typical level of a ground surface, atoms give birth to condensed matter physics, so atoms of solid behaviors also give birth to transition matter physics. In a system composed of gas or solid atoms, varying energy and force introduce different transition states. Orientational force of an electron either in the transition of gas atom or in the transition of solid atom is by varying potential energy under transitional energy. Thus, understandable concepts of cooling and heating are deduced from their respective gas atoms and solid atoms when recovering from their achieved ‘attaining liquid states’.
Computational Prediction of Mutational Effects on the SARS-CoV-2 Binding by Relative Free Energy Calculations
Authors: Zou Junjie , Yin Jian , Fang Lei , Yang Mingjun , Wang Tianyuan , Wu Weikun , Zhang Peiyu
Published: February 2020

The ability of coronaviruses infecting humans is invariably associated with their binding strengths to human receptor proteins. Both SARS-CoV-2, initially named 2019-nCoV, and SARS-CoV were reported to utilize angiotensin-converting enzyme 2 (ACE2) as entry receptor of human cells. To better understand the interplay between SARS-CoV-2 and ACE2, we performed computational alanine scanning mutagenesis, on the “hotspot” residues at protein-protein interfaces, by relative free energy calculations. Our results suggested that the binding strengths of SARS-CoV and SARS-CoV-2 to the host receptor are comparable. Free energy calculations showed a promise in assessing the infectious ability of viruses on a physical basis, and can also provide useful information for the design of antiviral drugs.
Forcing or Forced Exertions in Amalgamation of Nanoparticles and Particles inside the Solution
Authors: Ali Mubarak , Lin I-Nan
Published: February 2020

The study of forcing or forced exertions in amalgamating or amalgamated different featured nanoparticles and particles is important for the scientific societies. Observing live dynamics of nanoparticles and particles in the course of their amalgamation inside the solution is a challenging task. It is difficult to discuss amalgamating nanoparticles and particles only based on their visualized dynamics. However, suitably captured microscopic images of agglomerations of nanoparticles and particles can identify different modes of forcing or forced exertions. Nanoparticles and particles just at resting positions amalgamate under resultant differences of exerting forces not only related to poles of occupied quadrants, but also related to poles of their own drawn origins. In this context, colloidal entities amalgamating inside the solution from their directing sides experience a greater exertion of force. In amalgamation of nanoparticles and particles, the exerting force is mute, alert and functioning successively; contrarily, the energy behavior remains functioning, alert and mute successively. Amalgamations depend on the features and conceived focusing lengths of colloidal entities, which are through the origins of references of their exerting forces under the resultant differences. In amalgamation of nanoparticles and particles having geometrical shapes, electrons of their elongated atoms along each side deal with even exertions of force. This is not the case in nanoparticles and particles of distorted shapes. Colloidal nanoparticles and particles are considered the best candidates to track nature of exerting forces, and so is the case with energy behaviors, too.
Comparison of organoleptic, protein, lipid and flavonoid content of commercial starter and isolated culture red dragon fruit peel yogurt
Authors: Mardiana  , Budiono I. , Putriningtyas N.D.
Published: February 2020

Red dragon fruit peel can be processed into yogurt. Yogurt is a coagulated milk product
obtained from the lactic acid fermentation-yogurt made from various milk, whether fresh
milk, skim milk, or even full cream milk. The additions of red dragon fruit peel may
enhance the taste and the therapeutical values. This study was aimed to compare the
organoleptic properties, protein, lipid, and flavonoid content of commercial starter and
isolated culture red dragon fruit peel yogurt. Red dragon fruit peel yogurt was made with
amounts of red dragon fruit peel (25% w/v), full cream milk, sucrose and, commercial
starter (Lactobacillus bulgaricus, Lactobacillus acidophilus, Streptococcus thermophilus,
Bifidobacterium) or isolated culture (L. bulgaricus and S. thermophilus). Hedonic scale
test form was used for measuring organoleptic properties. Protein content was used
Kjeldahl method, lipid content was used Soxhlet method, and flavonoid content was used
chromatography. This research showed that protein and lipid contents in red dragon fruit
peel yogurt with commercial starter were higher than red dragon fruit peel yogurt with
isolated culture. Flavonoid content in the isolated culture yogurt was higher than
commercial starter yogurt. Organoleptic properties between groups were significantly
different (p<0.05). Red dragon fruit peel yogurt used isolated culture has a good chance of
getting a positive reception from the public and has potential as a functional food.
Estudo Sobre Docência Ampliada Nos Processos De Ensino-Aprendizagem Brasileiros
Authors: Ferreira Arthur Vianna
Published: February 2020

O presente artigo tem como objetivo a ampliação do conceito de docência na formação inicial de professores em Licenciaturas. A partir da legislação brasileira (LDB de 1996, as Diretrizes Curriculares Nacionais para a formação dos professores de 2015 e o Plano Nacional de Educação de Direitos Humanos de 2007) torna-se obrigatório a preparação dos indivíduos para atuação em espaços não escolares. Assim sendo, o campo teórico da Pedagogia Social se apresenta como espaços formativos para estudantes de licenciaturas, de maneira especial, a Pedagogia da Convivência de Xesús Jares (2007) que valoriza as relações sociais estabelecidas entre educador no processo de ensino-aprendizagem em ambientes não escolares.
Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020
Authors: Okada Pilailuk , Buathong Rome , Phuygun Siripaporn , Thanadachakul Thanutsapa , Parnmen Sittiporn , Wongboot Warawan , Waicharoen Sunthareeya , Wacharapluesadee Supaporn , Uttayamakul Sumonmal , Vachiraphan Apichart , Chittaganpitch Malinee , Mekha Nanthawan , Janejai Noppavan , Iamsirithaworn Sopon , Lee Raphael TC , Maurer-Stroh Sebastian
Published: February 2020

We report two cases of coronavirus disease 2019 (COVID-19) in travellers from Wuhan, China to Thailand. Both were independent introductions on separate flights, discovered with thermoscanners and confirmed with RT-PCR and genome sequencing. Both cases do not seem directly linked to the Huanan Seafood Market in Hubei but the viral genomes are identical to four other sequences from Wuhan, suggesting early spread within the city already in the first week of January.
Transmisi Strain Wuchereria bancrofti Periodik Nokturnal oleh Culex quinquefasciatus di Kota Pekalongan
Authors: Ramadhani Tri , Hadi Upik Kesumawati , Soviana Susi , Irawati Zubaidah
Published: February 2020

Wuchereria bancrofti dikenal sebagai penyebab filariasis limfatik di Kota Pekalongan. Kegiatan ini dilakukan untuk mencari upaya dalam pengendalian penularan filariasis limfatik yang lebih efektif dan efisien. Tujuan penelitian untuk mendiskripsikan perilaku mikrofilaria Wuchereria bancrofti yang ditularkan oleh Culex quinquefasciatus. Uji periodisitas dilakukan pada enam orang relawan yang positif mengandung mikrofilaria hasil survei darah. Pengambilan darah dilakukan setiap dua jam sekali selama 24 jam (12 kali pengamatan). Uji periodisitas cacing filaria menggunakan formula Aikat dan Das . Hasil survei darah menunjukkan dari 500 sampel darah sebanyak 17 orang positif mikrofilaria (mf rate = 3,4%). Sebagian besar mikrofilaria muncul antara pukul 22.6'36" sampai 03.56'24" yang menggambarkan periodisitas mikrofilaria Wuchereria bancrofti yang nokturnal. Kasus filariasis limfatik memiliki gelombang yang harmonik atau sirkardian dengan indeks periodisitas lebih dari 100%. Hasil penelitian ini akan sangat membantu dalam mengevaluasi dan memantau program pengobatan massal yang sedang berjalan untuk eliminasi filarisis limfatik di Kota Pekalongan.
Laccase‐catalyzed, Phytochemical‐mediated Protein Crosslinking Conjugates
Authors: Chai Tsun‐Thai , Xiao Jianbo , Dass Sharmila Mohana , Wong Fai‐Chu
Published: February 2020

Laccase is a Class 1 oxidoreductase enzyme, which catalyzes the oxidation of a wide range of phenolic substrates. Previously, several reviews had highlighted on the industrial importance of laccase, including in food industry. Similarly, the ability of laccase to crosslink and polymerize food protein molecules had also been reviewed. However, no much review information is available on the crosslinking of protein molecules, mediated by phytochemicals. In this review, we highlighted on the laccase‐catalyzed, phytochemical‐mediated protein crosslinking conjugates, and their associated functional changes, reported by different research groups over the last 10 years. In many of these reported studies, milk protein components are utilized, along with the addition of selected phytochemicals (chlorogenic acid, ferulic acid). As proteins are major dietary components, while phytochemicals are plant‐derived chemicals with well‐studied bioactivities, their conjugations could potentially lead to the identification of novel health‐promoting compounds.
Percepciones sobre la muerte en la infancia temprana: estudio cualitativo
Authors: Melguizo Martín Ana Isabel , Fernández-Castillo Antonio
Published: February 2020

Este trabajo de investigación tiene como objetivo principal explorar a través de un estudio cualitativo, la visión y conocimientos previos que se poseen a edades infantiles tempranas sobre la muerte. Para la recogida de datos, se ha utilizado una entrevista y el dibujo de los participantes. En el estudio participaron 28 estudiantes de edades comprendidas entre 4-5 años. Entre los resultados más interesantes obtenidos destaca la visión infantil sobre la muerte que incluye que las personas muertas están tristes, dormidas, que van al cielo y al cementerio, cuando mueren, y que se puede curar o despertar a los muertos. Este estudio es relevante para el ámbito educativo, puesto que es una manera de explorar las percepciones y conocimientos que poseen los menores en estas edades sobre la muerte. Asimismo, aporta sugerencias sobre cómo tratar esta temática de la forma más natural posible para favorecer la aceptación de la misma, la superación del duelo y la eliminación de mitos.
The Efficiency of Kamavit®-forte in the Treatment of Erectile Dysfunction and Diseases in Men, Leading to Infertility
Authors: О. Д. Нікітін
Published: February 2020

An erection disorder is the most frequently observed phenomenon in sexual practice, the frequency of which increases with age and is associated with conditions such as partial age related immunodeficiency, diabetes mellitus, depression, atherosclerosis, dyslipidemia, endothelial failure and stress.The objective: to study the efficiency and safety of Kamavit®-forte in the treatment of erectile dysfunction and male infertility.Materials and methods. We examined 60 patients aged 23 to 62 years with ED lasting from 1 to 8 years. The study was conducted for 3 months, patients of the main group (MG) took Kamavit®-forte 1 tablet 3 times a day for 90 days.Results. Before treatment, the testosterone level was 3,1±0,5 ng/ml, after – 6,9±0,3 ng/ml. Thus, after treatment, a significant (p<0,05) increase in blood testosterone levels was observed, which led to the stimulation of sexual function, in particular, libido. Before treatment, libido was retained in 7 (23,3%) patients, and after treatment, in 27 (90%) patients with hypertension. There is a clear tendency to improve an erection according to the subjective assessment of those examined as a result of taking the study drug. So, if before treatment a full erection was in 12 (40%), patients and a partial erection – only in 10 (33,3%), then after a course of taking the drug, a full erection was restored in 23 (76,7%) and in general 29 (96,7%) patients were able to coitus.Conclusion. The appointment of Kamavit®-forte led to a significant increase in ICEF indicators: achieving an erection – by 89,4%, erection during sexual stimulation – by 68,4%, sufficiency of an erection – by 66,7%; a significant increase in the parameters characterizing the sexual activity of patients: erectile function – by 86%, sexual intercourse – by 84%, orgasm – by 79,4%, libido – by 84,9%. With the use of Kamavit®-forte, an improvement in most spermogram indicators was observed; the volume of ejaculate increased, the concentration of sperm, their total number, motility, the number of live sperm, decreased the number of leukocytes, red blood cells, liquefaction time, the number of pathological forms of sperm.
Features of the Prevention of Absorbent Salt Formation of Internal and External Drainages During Prolonged Drainage of the Upper Urinary Tract
Authors: Р. В. Савчук  , Ф. І. Костєв  , О. М. Колосов  , А. П. Піддубняк  , В. О. Васілевський
Published: February 2020

The objective: to evaluate the effectiveness of the phytotherapeutic drug Canephron® N in the prevention of absorbent salt formation of internal and external drains with prolonged drainage of the upper urinary tract.Materials and methods. The study included 76 patients aged 16 to 65 years with drainage of the kidneys due to obstructive uropathy. Depending on the chosen treatment tactics, patients were divided into two groups. The main group (n = 49) in combination with standard care for stents received a phytopreparation Canephron® N 2 tablets three times a day. Patients in the control group (n = 27) received only standard stent care. The sizes of the renal cavities were evaluated using a furosemide test, the reaction to a urine nitrite test, the presence of bacteriuria and the frequency of salt incrustation of stents and drains.Results. The quality of the functioning of drainage systems in the main group was significantly higher than that of the control group. The test with furosemide showed a smaller size of the kidney bowls in the main group by 24.3% than in patients of the control group with external drainage and 17% less with internal drainage. Positive indicators of the nitrite test in the group of patients who used the Canephron® N phytopreparation in complex therapy were lower by 54% and 53%, respectively, in the subgroups of external and internal drainage compared to the control group. Some patients with saline occlusion of the drainage systems accounted for 16% in the main group versus 85% in the control group.Conclusion. The use of Canephron® N in patients with drainage of the upper urinary tract can prevent the development of salt incrustation of stents, improve the quality of drainage, and also prevent the development of microbial inflammatory processes in the urinary tract.