bluuebunny/crossref_metadata_2025 huggingface dataset:
Humor e religião na pandemia
Authors: Regiani Herivelton , Borelli Viviane
Published: April 2022

A partir da circulação de informações sobre a pandemia de Covid-19 em grupos de WhatsApp, analisa-se materialidades discursivas construídas com humor e que evocam elementos religiosos. São identificados efeitos de sentidos, como chamada de atenção, alívio de tensões, estabelecimento de identificações e afetos, além de reforço de crenças ou sinalização de atitudes indesejáveis. O estudo colabora na compreensão dos modos como sujeitos e grupos lidam com as crises, limitações e adversidades.
história de um subgênero ficcional
Authors: Meigre e Silva Marcos Vinicius
Published: April 2022

Apresento uma proposta de mapeamento das telenovelas espíritas, a partir da consulta a listas e vídeos de comentaristas sobre telenovela brasileira. A sistematização acompanha a cronologia da própria televisão brasileira e da telenovela em particular. Amparo-me em autores que investiram na proposição de linhas cronológicas, respectivamente, para a TV e para a telenovela nacional a fim de captar traços constitutivos do audiovisual brasileiro. Como corpus, adoto 12 listas que enumeram as principais telenovelas espíritas produzidas no país. Assim, estabeleço 5 fases da telenovela espírita brasileira: (1) pioneirismo nascente com o formato telenovela; (2) crescimento dúbio entre a fidelidade doutrinária e o ecumenismo; (3) recrudescimento do espiritismo na ficção e avanço do sincretismo; (4) virada espírita e consolidação do subgênero; e (5) explosão de telenovelas espíritas, concomitantes a outros segmentos religiosos de projeção no audiovisual.
Comparison of sentinel lymph node biopsy and elective neck dissection for oral cavity squamous cell carcinoma of the oral cavity in patients with clinically N0 necks: A systematic review and meta-analysis
Authors: Kang Yun Jin , Kang Min Ju , Ahn Hee Sun , Hwang Se Hwan
Published: April 2022

Aims: We compared the prognostic utility of sentinel node biopsy (SNB)
and elective neck dissection (END) in patients with early (T1–2) oral
cavity squamous cell carcinoma (OSCC) and clinically N0 necks. Methods:
We searched the PubMed, SCOPUS, Embase, Web of Science, and Cochrane
library databases up to March 2022. The hazard ratios (HRs),
Kaplan–Meier curves, p-values, and survival outcomes were extracted,
along with all study characteristics. Methodological quality was
assessed using the Cochrane Risk of Bias tool. Results: Twelve studies
involving 10,583 patients were finally included. We found no significant
differences in overall survival (OS) (HR = 1.1226; 95% confidence
interval [CI]: 0.9263; 1.3604), disease-free survival (DFS) (HR =
1.0797; 95% CI: 0.8765; 1.3300) or disease-specific survival (DSS) (HR
= 0.8652; 95% CI: 0.6531; 1.1462) between the two groups. Heterogeneity
was not detected in pooled OS, DFS, and DSS analyses (all I2 <
50). In subgroup analyses by follow-up period (3, 5, and 10 years), SNB
and END had similar prognostic value. Conclusions: We found no
significant difference in OS, DFS, or DSS between patients with early
OSCC and clinical N0 necks evaluated via SNB and END, suggesting that
SNB might be a valuable alternative to END for the management of early
stage clinically node-negative OSCC.
An Efficient Fractional Polynomial Spline for Compute FDEs with Stability Analysis
Authors: Hamasalh Faraidun , hama seaman
Published: April 2022

To compute the solution of FDEs, we create a fractional polynomial
spline in this paper; the spline interpolation with fractional
polynomial coefficients must be constructed using the Caputo fractional
derivative. Error bounds were studied and a stability analysis was
completed for the given spline function. Four examples were used to
consider the numerical explanation for the provided method. The research
suggests that the fractional spline function, which interpolates data,
is useful and accurate in solving unique problems.
HIDEA Syndrome: A rare cause of congenital hypoventilation in a premature infant
Authors: Lim Alicia , Tan Pih Lin , Visruthan Nirmal Kavalloor , Fong Nikki , Viegelmann Guadalupe , Tan Yi Hua
Published: April 2022

Background: HIDEA syndrome is a rare and novel disease characterised by
hypotonia, hypoventilation, intellectual disability, epilepsy and eye
abnormalities. Diagnosis is made by genetic testing with exclusion of
other causes of hypoventilation. We present a case of a neonate born
premature to a pair of consanguineous parents with an atypical course of
bronchopulmonary dysplasia subsequently diagnosed with HIDEA syndrome.
Conclusion: This is the first case report of HIDEA syndrome in South
East Asia, broadening our understanding of the full phenotypic pattern
of HIDEA syndrome. Patients with HIDEA syndrome are at risk of
prematurity and hypothyroidism. Early diagnosis is crucial to optimise
adequate ventilatory management including early tracheostomy as many
require lifelong continuous or intermittent ventilation. This minimises
the complications of chronic hypoxia and reduces mortality risk. HIDEA
syndrome is an important differential diagnosis in the consideration of
an infant who presents with hypoventilation.
Status and Genetic Diversity of Hipposideros pratti in the Northernmost Part of Its Distribution
Authors: Liu Wei , Wang He , YANG PING , HAO YAN , song hang , Bu zhen , Niu xing
Published: April 2022

Hipposideros pratti is species of bat distributed in caves from
Southeast Asia to the Qinling-Funiu Mountain area in China. To
understand the dynamic changes in its distribution and evaluate the
current health status of the species, we reviewed 48 caves in the
northernmost area of the H. pratti distribution and conducted the first
analysis of genetic diversity for the species in the region. H. pratti
was only detected in three caves, the four previously distributed caves
and the remaining 41 previously undistributed caves were not observed.
An analysis based on microsatellite markers revealed a few key points.
1) The average number of observed alleles (Na) of H. pratti in the
region was 3.94, and the average observed heterozygosity (Ho) was
0.5293. All three populations were in Hardy–Weinberg equilibrium. 2)
Intra-population was the predominant genetic variation of the H. pratti
population. 3) H. pratti in the region experienced a bottleneck effect.
We found that the three caves where H. pratti are currently distributed
face varying degrees of human interference and the populations are
threatened. Management strategies, including appropriate countermeasures
to reduce human interference in caves, are urgently needed.
Medicines legislation and regulation in England, 1500--2020
Authors: Ferner Robin , Aronson Jeffrey
Published: April 2022

The initial purposes of regulation of medicines in England were
principally to raise government revenue, to discourage murder by
poisoning, and to regulate the activities of pharmacists. It was only
much later that regulators sought to ensure that medicines were of good
quality, reasonably safe, and at least somewhat effective, and to
regulate misuse of drugs. Here we survey the history of the regulation
of medicines and poisons in England from the perspective of clinicians
with an interest in therapeutics.
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically Ill children: an observational, prospective, controlled study
Authors: Neupane Bikalpa , Pandya Hitesh , Pandya Tej , Austin Rupert , Spooner Neil , Rudge James , Mulla Hussain
Published: April 2022

Aims: Altered physiology caused by critical illness may change midazolam
pharmacokinetics (PK) and thereby result in adverse reactions and
outcomes in this vulnerable patient population. This study set out to
determine which critical illness related factors impact on midazolam
pharmacokinetics in children using population PK modelling. Methods: An
observational, prospective, controlled study of children admitted to
University Hospitals Leicester NHS Trust receiving IV midazolam as part
of routine care. Children recruited into the study were either
critically-ill receiving continuous infusions of midazolam or otherwise
well, admitted for elective day-case surgery (control) who received a
single IV bolus dose of midazolam. Blood midazolam and 1-OH-midazolam
concentration and patient clinical data were used to develop a
population PK model and to determine covariates which affect midazolam
disposition during critical illness. Results: 35 patients were recruited
into the critically ill arm of the study, 54 children into the control
arm. Modelling demonstrated a significant change in midazolam clearance
with acute inflammation (measured using C-Reactive Protein, CRP),
cardio-vascular status and weight. Simulations predict that elevated CRP
and compromised cardiovascular function in critically ill children
result in midazolam concentrations up to 10-fold higher than healthy
children. Conclusions: Raised CRP and compromised cardiovascular
function significantly reduce midazolam clearance. The extremely high
levels of midazolam observed in some critically-ill children indicate
that the current therapeutic dosing regimen for midazolam can lead to
over-dosing. Clinicians should be aware of this risk and intensify
monitoring of such patients.
Mixed land use levels in rural settlements and their influencing factors: A case study of Pingba Village in Chongqing, China
Authors: Chen Hongji , Su Kangchuan , Peng Lixian , Bi GuoHua , Zhou Lulu , Yang Qingyuan
Published: April 2022

Mixed land use provides an important means of promoting the intensive
and efficient use of land resources and stimulating endogenous
development power in rural areas. This paper selects Pingba Village in
Chongqing as the research area, and subdivid the land use types in the
rural settlements according to fieldwork results and the principle of
dominant function. Moreover, a land mixed use measurement system for
rural settlements was constructed to analyze their levels of mixed land
use. Furthermore, the influences of the natural environment, social,
economic and other factors on mixed land use were comprehensively
explored. The results show that 1) the mixed land use of rural
settlements in the study area was at a medium level and showed
significant spatial variability. 2) The difference in the natural
environment determines the level of mixed land use and the basic pattern
of its spatial differentiation. Social and economic factors, such as
resident population and average household income, are key impact
factors. Rural tourism resources, homestead agglomeration policies have
important impacts on the level of mixed land use. In conclusion, the
research suggests that mixed land use is an important way to boost rural
revitalization. In the future, village planning could introduce the
concept of mixed land use to improve the efficiency of land use,
optimize the land use structure according to local conditions. In
addition, it is necessary to scientifically and rationally guide rural
settlements to agglomerate appropriately to improve the utilization
efficiency of land resources and public service resources.
Tracking Democracy In Islam
Authors: Junaidi M. , Sudaryono Sudaryono
Published: April 2022

This paper aims to answer the question “Is democracy in conflict with Islam?” This paper also discusses the values contained in democracy. This paper uses a normative legal research method that is descriptive and analytic to describe the implementation of government systems and political systems in Islam. Then analyze it with democratic values as a system of government and a political system. The research results obtained a brief description of democracy as a political system and government system in the era of the Prophet and the era of Khulafaturrasyidin to determine the democratic values contained. In the end, this paper is one of the answers to the discourse that has been a growing polemic between democracy and Islam.
Legal Analysis of Shareholders as an Organ of The Company Viewed From Commercial Code
Authors: Nugraheni Prasasti Dyah
Published: April 2022

This paper aims to explain the authority possessed by the members of Shareholders in the Articles of Association. In Articles of Association of Limited Liability Company, it contains regulations governing an operational activity that will become the purpose of Limited Liability Company. The Articles of Association have compelling and binding nature for all members of Shareholders, all members of the Board of Commissioners, and all members of the Board of Directors. Members of Shareholders are an organ owned by Limited Liability Company whose authority owned by all members of the Board of Commissioners and all members of the Board of Directors. One of the authorities possessed by the members of Shareholders is to appoint the members of the Board of Commissioners and members of the Board of Directors. In this paper, the author used research methods of normative and juridical, meaning that the writing method is carried out by analyzing secondary legal materials or library materials to find solutions to problems of legal problems arising and to use a problem approach based on laws or legal rules in general about the powers of the shareholders that apply to such event and approach the problem based on a conceptual basis. The results show that the position of the shareholders is not higher than and even equal to the position of the Board of Commissioners and Board of Directors. Whereas in the Indonesian Commercial Code, it stipulates that the position of shareholders is the highest in a Limited Liability Company.Keywords: Authority of Shareholders; Company Law Number 40 of 2007; Limited Liability Company
Restorative Justice in Criminal Acts of Corruption
Authors: Pratama Vega
Published: April 2022

This article intends to elaborate the model of corruption crimes resolved in a system of restorative justice that occurs in the State of Indonesia. This article emphasizes that efforts to eradicate corruption are not merely to provide punishment for those who are proven with the most severe punishment, but so that all countries that are caused by acts of corruption prevention can be returned in a short time. Technically, this study finds that there are 3 (three) conditions that cause the loss of the unlawful nature of a criminal act of corruption, namely: the suspect or defendant is disadvantaged; the state is not disadvantaged; community served. Based on the three conditions illustrate if the criminal act of corruption has returned the entire proceeds of the criminal act of corruption along with all the profits obtained from the results of the criminal act of corruption by the criminal act of corruption then basically the perpetrator is disadvantaged, the country does not suffer financial losses and the public can be served through returning all proceeds of corruption and all the benefits thereof. As a consequence, in order to create a restoring judicial process, this article desires to reduce the socio-economic burden of the state and law enforcement energy in handling cases of corruption.
Environmental Judge Certification in an Effort to Realize the Green Legislation Concept in Indonesia
Authors: Shanty Saleh Indah Nur , Spaltani Bita Gadsia
Published: April 2022

The purpose of this research is to find out, analyze, and explain the certification of environmental judges in an effort to realize the concept of green legislation in Indonesia. This research is a normative or doctrinal legal research. The data analysis was carried out qualitatively, so it is hoped that the discussion can accurately answer the problem formulation. This research resulted in the following conclusions: first; Environmental judge certification is important in the effort to implement green legislation in Indonesia based on four considerations, namely: in the context of realizing the 1945 Indonesian Constitution as a green constitution, the strategic role of judges’ decisions in realizing human and environmental justice, contributing to the effectiveness of environmental law enforcement. as well as for the integrated exercise of judicial or judicial powers in the principles of trias politica. Second, that with regard to the application of environmental judge certification in an effort to realize green legislation, the government has issued the RI KMA Decree Number: 134/KMA/SK/IX/2011 which regulates Certification of Environmental Judges which is used as a reference point for legal development regarding the judge certification system. environment in the settlement of civil, criminal and state administration cases in the environmental field. At the same time, judges training and coaching are conducted every year so that the need for the number of certified environmental judges is met in each region. Third, that the direction of legal reform relating to the provisions of environmental judge certification in an effort to realize green legislation can be carried out through guarding the environmental judge certification policy by cooperating with various parties; increase the capability of judges in the field of environmental science; as well as strengthening the judges’ thinking paradigm so that it is pro-environment or pro-natura (green thinking) as a form of embodiment of environmental legal norms according to the green constitution and green legislation in Indonesia. The benefit of this research is in the context of gaining insight among legal experts and legislative parties in improving the substance of law, especially environmental law which represents the concept of green legislation. This research contains novelty and differences from other research in terms of discouraging ideas and models of public policy reform with the concept of green legislation which is used as a legal umbrella in the form of laws on legal substances related to environmental judge certification.
Evaluation of early pregnancy risk factors for venous thromboembolism in Turkish pregnant women: a prospective study
Authors: Kırlangıç Mehmet Mete , Mefkure Eraslan Şahin
Published: April 2022

Objective: Venous thromboembolism (VTE), a condition during pregnancy that manifests as deep vein thrombosis and pulmonary embolism, is the third most common cause of death in 0.01–0.2% pregnant women worldwide each year. Because this risk has increased in pregnant women and is treatable, early diagnosis and treatment would save lives. The aim of this study was to evaluate the early pregnancy risk factors for VTE in Turkish pregnant women. Methods:In this prospective study, 480 pregnant women between the ages of 18 and 45 years and who applied to our clinic within their first trimester (4–14 weeks) of pregnancy were enrolled in the study. Because the risk factors of the patients were to be determined, there were no exclusion criteria. The antepartum thromboembolism risk parameters were determined according to Risky Pregnancies Management Guide of Turkish Ministry of Health Guidelines. Results: There were 336 (70%) pregnant women in the low-risk group, 62 (12.9%) in the medium-risk group, and 82 (17.1%) in the high-risk group. The permanent parameters within the groups that determined the risk factors were individually evaluated. Conclusion: Our results indicated that 30% of the study population needed low-molecular-weight heparin (LMWH) prophylaxis, of whom 12.9% were in the medium-risk group, and 17.1% were in the high-risk group. VTE risk occurs from a combination of minor factors, rather than one high-risk factor. In addition, most of these VTE risk factors can be easily corrected and prevented in the pre-gestational phase or first trimester.
First trimester diagnosis of an unusual case of double aneuploidy with karyotype 48,XXY,+18 (Klinefelter-Edwards syndromes)
Authors: Gölbaşı Hakan , Saka Güvenç Merve , Gölbaşı Ceren , Ömeroğlu İbrahim , Ekin Atalay
Published: April 2022

Objective: Double aneuploidy cases involving autosomal and sex chromosomes are very rare. Therefore, it is difficult to determine the clinical features and prognosis of these cases. In this case, a fetus with 48,XYY,+18 karyotype is presented. Case(s): Cystic hygroma, cleft lip and palate, and clubbed foot were detected in the prenatal ultrasonographic evaluation of a 31-year-old pregnant woman at 13 weeks of gestation. Chorionic villus sampling revealed double aneuploidy including Klinefelter and Edwards syndromes. The molecular result was consistent with the occurrence of nondisjunction error involving chromosome 18 in maternal meiosis I (mat MI) but the finding of the extra X chromosome could not be fully explained. Post-abortion fetal pathology specimen confirmed prenatal diagnosis. Conclusion: Double aneuploidy cases may rarely present with structural anomalies due to maternal meiosis error, without advanced maternal age, as in this case.
The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation
Authors: Dagklis Themistoklis , Şen Cihat , Tsakiridis Ioannis , Villalaín Cecilia , Allegaert Karel , Wellmann Sven , Kusuda Satoshi , Serra Bernat , Luna Manuel Sanchez , Huertas Erasmo , Volpe Nicola , Ayala Rodrigo , Jekova Nelly , Grunebaum Amos , Stanojevic Milan
Published: April 2022

This practice guideline follows the mission of the World Association of Perinatal Medicine (WAPM) in collaboration with the Perinatal Medicine Foundation (PMF), bringing together groups and individuals throughout the world with the goal of improving the use of antenatal corticosteroids (ACS) for fetal maturation. In fact, this document provides further guidance for healthcare practitioners on the appropriate use of ACS with the aim to increase the timely administration and avoid unnecessary or excessive use. Therefore, it is not intended to establish a legal standard of care. This document is based on consensus among perinatal experts throughout the world and also serves as a guideline for use in clinical practice.
The use of antenatal corticosteroids for fetal maturation in COVID-19: clinical practice statement by WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation
Authors: Dagklis Themistoklis , Şen Cihat , Tsakiridis Ioannis , Villalaín Cecilia , Allegaert Karel , Wellmann Sven , Kusuda Satoshi , Serra Bernat , Luna Manuel Sanchez , Huertas Erasmo , Volpe Nicola , Ayala Rodrigo , Jekova Nelly , Grunebaum Amos , Stanojevic Milan
Published: April 2022

This statement follows the mission of the World Association of Perinatal Medicine in collaboration with the Perinatal Medicine Foundation, bringing together groups and individuals throughout the world with the goal of improving the use of antenatal corticosteroids (ACS) for fetal maturation in Coronavirus Disease 2019 (COVID-19). Pregnant women with COVID-19 are at increased risk of hospitalization, admission to intensive care unit and mechanical ventilation compared to non-pregnant patients. Thus, obstetricians may face the dilemma of initiating maternal corticosteroid therapy for maternal indication while weighing its potential adverse effects on the fetus. As there is no evidence on the effect of betamethasone in pregnant women with COVID-19, dexamethasone should be preferably used for fetal maturation, if available. As a recommendation, for pregnant women with COVID-19 who are oxygen dependent or under mechanical ventilation and meet the criteria for ACS, the usual doses of dexamethasone should be administered, followed by oral prednisolone 40 mg OD or intravenous hydrocortisone 80 mg BD for up to 10 days.
Clinical characteristics and perinatal outcomes of pregnant women with Coronavirus-19 disease
Authors: Ömeroğlu İbrahim , Gölbaşı Hakan , Şahin Suzan , Kayhan Ömeroğlu Şeyda , Gölbaşı Ceren , Ekin Atalay
Published: April 2022

Objective: The aim of this study was to evaluate the maternal and perinatal outcomes of COVID-19 infection during pregnancy. Methods: We performed a retrospective review of medical records of 37 pregnant women with the diagnosis of COVID-19. The clinical characteristics, laboratory results, perinatal and neonatal outcomes were analyzed. Results: The majority of cases with COVID-19 were evaluated as mild (97.3%). None of the women needed intensive care unit or invasive mechanical ventilation and mortality were not observed. The most common symptoms were fever (62.2%) and cough (40.5%). Of all the pregnancies, 5.4% ended with abortion, 2.7% with stillbirth, and 10% of the infants were hospitalized in the neonatal intensive care unit. Neonatal mortality was not observed. Conclusion: In our study, none of the pregnant women with SARS-CoV-2 infection had severe illness. Vertical transmission of SARS-CoV-2 which was possible in several studies is not observed in our patient population.
Assessment of the roles of ABO blood types and Rh factors in gestational diabetes mellitus
Authors: Kırlangıç Mehmet Mete , Eraslan Şahin Mefkure
Published: April 2022

Objective: Gestational diabetes mellitus (GDM) is a leading causes of both maternal and neonatal morbidity and mortality, the frequency of which is increasing gradually because of the increasing age and obesity of the pregnant woman. The aim of the present study was to evaluate ABO blood types and Rh factors and their roles in GDM prevalence. Methods: This retrospective study was conducted in the Obstetrics & Gynecology Clinic of Tuzla State Hospital. Between January 1, 2015 and May 1, 2021, 1017 pregnant women who were admitted to our clinic were evaluated according to the presence of GDM using the hospital database system. The ABO blood types and Rh factors were determined in all patients and GDM prevalence was compared among the groups. Results: The 1017 pregnant women had single- and double-step oral glucose tolerance tests and the ABO blood type results were included in the study. Of the 1017 women, 241 (23.70%) had GDM and 776 (76.30%) were normal. The mean maternal age of the group with GDM was 30.9±4.8 years and it was 27.8±5.4 years in the normal group, which was a statistically significant difference (p<0.001). Of the 1017 pregnant women, 474 (46.61%), 162 (15.93%), 316 (31.07%), and 65 (6.39%) had the blood types A, B, 0, and AB, respectively, with no difference observed among them in terms of the presence of GDM (p=0.592). There were 886 (87.12%) pregnant women in the Rh(+) group and 131 (12.88%) in the Rh(-) group; the groups were similar in terms of the presence of GDM (p=0.503). Conclusion: Our results indicated that ABO blood types and Rh factors were not risk factors for GDM.
Prenatal diagnosis of Galen vein aneurysm: when to deliver?
Authors: Kesrouani Assaad , Daou Linda , Roumieh Dina
Published: April 2022

Objective: Prenatal diagnosis of Galen vein aneurysm using color Doppler has become relatively easy. Management and timing of delivery is however challenging because of cardiac function deterioration. Ultrasound follow-up is essential to detect signs of fetal cardiac failure which must be weighed against risks of prematurity. Postnatal deterioration of the vital signs can follow a short period of improvement after birth. This report illustrates the many pitfalls that could affect the final outcome, raising the issue of the proper timing for delivery. Case(s): A 23-year-old G1P0 spontaneous pregnancy was referred at 28 WA for a Galen Vein aneurysm. The ultrasound finding included a 35 by 14 mm vascular structure with a turbulent flow, occupying the central part of the head. After 48 hours in-hospital surveillance through non-stress tests twice daily, she had a cesarean section due to a persistent non-reactive fetal heart rate, with absent variability. Unfortunately, despite a stable state for the first ten days, the baby’s cardiac function deteriorated abruptly on day 11, and the baby died of heart failure despite medical management. Conclusion: The timing of delivery in cases with Galen vein aneurysm is challenging mainly in the case of premature babies, as the prognosis is globally bad. Postnatal deterioration of the vital signs can follow a short period of improvement after delivery.
Prenatal attachment in the pregnancy: its relationship with fear of childbirth
Authors: Uğurlu Meltem , Çoban Zehranur
Published: April 2022

Objective: The aim of this study was to determine the level of prenatal attachment of pregnant women and its relationship with fear of childbirth. Methods: This descriptive and cross-sectional study was conducted with a total of 125 pregnant women who applied to outpatient obstetric unit of a training and research hospital in Ankara between September 2019 and March 2020. The data were collected using the “Participant Information Form”, “Wijma Delivery Expectation Questionnaire Version A (W-DEQ A)” and “Prenatal Attachment Inventory (PAI)”. Results: The average PAI score of pregnant women is 67.19±9.56. It was found that there was a significant relationship between the education level of pregnant women and the average PAI score (p=0.002). There was no significant difference between the gestational age, income level, education level, working status, obstetric characteristics of pregnant women, and average PAI score (p<0.05). A negative, weak, and significant relationship was found between W-DEQ A and PAI scores (r=-0.183, p=0.041). According to the linear regression model, it was found that the age, duration of the marriage, and fear of childbirth of pregnant women had a significant effect on the total score of PAI (p=0.001, p=0.018, p=0.019, respectively). Conclusion: The high fear of childbirth, young age and short marriage time may decrease prenatal attachment. As the fear of childbirth of pregnant women increases, the level of prenatal attachment decreases.
PKM OLAHAN TELUR BEBEK UNTUK MEMENUHI KEBUTUHAN GIZI DAN MENINGKATKAN PENDAPATAN MASYARAKAT DESA RUMAH SUMBUL
Authors: Rimbawati Rimbawati , Siregar Rahmad Bahagia
Published: April 2022

Rumah Sumbul village is one of the disadvantaged villages in Deli Serdang district due to the fact that the majority of the villagers are rubber farmers who experienced a significant decline in selling prices in the past three years ago. The increasingly heavy economic pressures as a result of the decline in rubber prices forced people to change professions into laborers at oil palm plantations to meet their daily needs. This condition affects the nutritional needs of the community directly. Based on the statement of the Sumbul Village Chief, Mr. Makmur Barus, to the Team, there were 30 people raising ducks and joined in three groups of poultry scattered in several hamlets. But the lack of knowledge in producing processed duck eggs makes all citizens just sell their eggs at a price of IDR 2,000/grains. Based on these problems the PKM aimed to conduct training in making various flavored salted egg preparations and provide training in production and marketing management. Accordingly, partners were able to produce various types of processed duck eggs as souvenirs typical of Tigajuhar for sale to traditional markets and tourist attractions in the region, such as Lake Linting, Kawah Putih and Sibiru-blue beach, which is approximately 2 to 5 km from the Partner's location at a price of IDR 4,000/grains. It is expected that the locals can increase their per capita income while at the same time meeting the nutritional needs of the community.
PEMBERDAYAAN IBU-IBU PKK MELALUI PELATIHAN DAN PENDAMPINGAN PRODUKSI MINYAK ANGIN AROMATERAPI
Authors: Leviana Fransiska , Herdwiani Wiwin , Saptarini Opstaria
Published: April 2022

The use of aromatherapy was very well known in the community. The best-selling and quickly accepted product was aromatherapy oil. The benefits of aromatherapy were not only for health, but also for calming the mind and relaxation. Empowerment of PKK as members of the community and still classified as productive workforce was very important to do, aiming to foster awareness and independence in doing business, while expanding employment to increase family income in an effort to achieve a happy and prosperous family. In relation to efforts to foster and develop the potential of families and regions, it can be done through various alternative activities, including training in making aromatherapy oil product. The purpose of this community service program was to empower mothers and women through training and assistance in aromatherapy oil production. The target of this activity was PKK RW 04 Mojosongo Village, Jebres District, Surakarta City. The output of this activity was improving the skills of the community to produce aromatherapy wind oil and motivating business opportunities for PKK mothers. The method used in this service was training and assistance in aromatherapy oil production.
PENDAMPINGAN PEMBUATAN OVERALL JUMPSUIT APD GOWN, PENCARIAN SUMBER DANA DAN MANAJEMEN DISTRIBUSI KE RUMAH SAKIT
Authors: Yudianti Fr. Ninik , Siswanto F.A. Joko , Anggraini Fr. Reni Retno
Published: April 2022

The activities of service were to provide assistance in the making of the Overall Jumpsuit APD Gown, funding management and distribution. There are three partners involved in this service, namely Partner-1: Gavrilla Fashion Studio, Partner-2: Sanata Dharma alumni and other donors, and Partner-3: Panti Rapih Hospital and small hospitals in Yogyakarta and its surroundings.The steps in service incclude a. Conducting discussions with a designer-entrepreneur for the manufacture of the Overall Jumpsuit APD needed by the hospital, b. Providing assistance in making the Overall Jumpsuit APD Gown: Selection of APD models, taking pictures, etc. c. Mentoring in raising funds to purchase raw materials and paying up tailors, and d. Mentoring for the distribution of Overall Jumpsuit APD Gowns that were handed over to the hospitals in need.The result of services, Gavrilla Fashion Studio, could produce large quantities of standard APD Overalls Jumpsuit. The making of APD was supported by many donors to buy materials and pay for sewing fees. The finished goods of APD were distributed and collected by the user's hospital.
Effectiveness of ChKM solution compared to triple-antibiotic paste as an intracanal medicament for bacteria that cause a chronic periapical abscess
Authors: Malinda Yuti , Azhara Dea Hanin , Harnung Kartikaning , Prisinda Diani
Published: April 2022

Introduction: Chronic periapical abscesses are caused by polymicrobial bacteria, including E. faecalis, S. mutans, S. sanguinis, and P. gingivalis. These bacteria can be eliminated with chlorophenol camphor menthol (ChKM) solution and triple-antibiotic paste (TAP) as an intracanal medicament. This study compared the effectiveness of ChKM solution to triple-antibiotic paste as an intracanal medicament for bacteria that cause a chronic periapical abscess. Methods: An experimental laboratory was conducted in-vitro with the microdilution method and optical density measurement using a spectrophotometer. The cell inhibition percentage was calculated to determine the MIC value. The MBC values were confirmed by cultivating the Mueller Hinton Agar samples, incubating them at 37°C for 24 hours, and observing bacterial growth. Bacteria did not grow in the medium at MBC value. The lower MIC and MBC were sensitive and could be an effective medicament choice. Results: The MIC ChKM solution inhibits E. faecalis ATCC 29212, S. mutans ATCC 25175, S. sanguinis ATCC 10556, and P. gingivalis ATCC 33277 were 4000, 4000, 2000, and 2000 µg/mL consecutively. While MIC of TAP were 6, 0.375, 0.75, and 1.5 µg/mL, respectively. Moreover, MBC of the ChKM solution were 32000, 32000, 8000, 8000 µg/mL and MBC of the TAP were 768, 24, 24, 96 µg/mL. Conclusions: ChKM solution and TAP effectively inhibited and killed E. faecalis, S. mutans, S. sanguinis, and P. gingivalis as an intracanal medicament, as seen from the MIC and MBC values. However, TAP is more effective than the ChKM solution because MIC and MBC values of TAP are much lower than the ChKM solution. This finding indicated that TAP is more effective at the lowest concentration than ChKM solution. It should be highlighted that this was an in-vitro study involving specific microbes; thus, further clinical research is needed.
The controlled release profile of risedronate emulgel to inhibit relapse movement in orthodontic treatment
Authors: Utari Tita Ratya , Kurniawan Muhammad Fariez , Andewa Shylvia Muchsin
Published: April 2022

Introduction: Relapse is one of the undesirable effects of orthodontic treatment. Prevention of relapse has been carried out with the use of retainer devices. Several studies also have been carried out to prevent relapse with pharmacological agents such as bisphosphonates. One of the strongest bisphosphonates is risedronate. Systemic use of bisphosphonates can cause bisphosphonate-related necrosis of the jaw (BRONJ). Systemic effects can be minimised by topical preparations locally, where the virgin coconut oil (VCO) emulgel is one of the topical preparations which controls the release of drugs. This study aims to analyse the release profile of risedronate emulgel as a material to inhibit relapse movement. Methods: This research was conducted in an experimental laboratory. Group 1 was emulgel without bisphosphonate risedronate with virgin coconut oil (VCO), Group 2 was VCO emulgel with bisphosphonates risedronate, and Group 3 was a pure bisphosphonate risedronate solution. Each group weighing 100 mg was placed in 10 ml PBS, and the release test was conducted with UV/VIS Spectrophotometer wavelength λ 262 nm at intervals of 1, 2, 4, 8, 24, 48, and 96 hours with three replications at each group. Results: Grup 2 yielded a controlled drug release of risedronate until 96 hours, while a pure solution of risedronate resulted in an uncontrolled drug release of risedronate, which was released entirely in 4 hours. Conclusion: Risedronate emulgel with VCO had a controlled drug release compared to pure bisphosphonate solution to potentially be applied topically to inhibit relapse movement.
Antibacterial activity of strawberry fruit extract against Streptococcus sanguinis (ATCC 10556)
Authors: Nurdin Denny , Dharsono Hendra Dian Adhita , Fatriadi Fajar , Sahara Elvi , Adang Rahmi Alma Farah , Gondowidjojo Yolanda Dwiutami , Kurnia Dikdik
Published: April 2022

Introduction: Streptococcus sanguinis is a facultative anaerobic Gram-positive bacteria known as a pioneer that plays a role in creating the biofilm in the oral cavity. Strawberry fruit (Fragaria x ananassa) is an edible fruit widely used for the study as their active compound synergy to improve health. This study aims to analyse the antibacterial activity of strawberry fruit against S. sanguinis (ATCC 10556). Methods: An explorative study was conducted with high concentration methanol extract from strawberry fruit. Antibacterial activity was tested on the methanol extract; afterwards, the extract was fractionated and divided into three fractions: water, ethyl acetate, and hexane. Zone of inhibition was used to assess the most effective fraction among those three, then continued by testing for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Results: Inhibitory zone of the ethyl acetate fraction from strawberry fruit 1%, 2%, 3% ,4% and 5% sequentially were 7.3 mm,10.2 mm, 12.3 mm, 16.3 mm and 16.1 mm. Ethyl acetate fraction of 4% was the most effective to create the zone of inhibition with a size of 16.3 mm compared to the others. The Minimum Inhibitory Concentration (MIC) value was 0.25%. It was obtained by diluting a 4% ethyl acetate fraction on a microplate. The Minimum Bactericidal Concentration (MBC) was 2%. Conclusion: Ethyl acetate fraction was an effective fraction from strawberry fruit and had antibacterial activity against S. sanguinis with the inhibitory zone in the concentration of 4%, MIC of 0.25%, and MBC of 2%.
Garantias fundamentais do investigado no interrogatório, no uso de algemas e na condução coercitiva
Authors: Maidl Cássia Regina da Silva , Vidal Nelson
Published: April 2022

O presente artigo tem como finalidade abordar os aspectos da investigação criminal, com observância às garantias fundamentais do investigado no curso do processo, com base na Constituição da República Federativa do Brasil de 1988 e nas decisões proferidas pela Suprema Corte. O objetivo é analisar a investigação criminal no processo penal brasileiro e quais as garantias fundamentais do investigado. Assim, é necessário compreender a investigação criminal através dos direitos e garantias fundamentais do investigado, no processo do interrogatório, no uso de algemas e verificar se sua integridade física e dignidade são garantidas, abordando por fim, a condução coercitiva e o direito a liberdade. A metodologia adotada é qualitativa e o método de abordagem é dedutivo, baseado em pesquisa teórica, pois possui análise bibliográfica realizada através da leitura de doutrina e artigos científicos de revistas renomadas da área jurídica. Através dos estudos realizados, foi possível observar que durante muitos anos as garantias fundamentais do investigado não foram completamente respeitadas, visto que no interrogatório a presença do advogado não era obrigatória até o ano de 2003. Assim como o uso de algemas, até a edição da Súmula Vinculante n. 11, era de uso comum e usado de maneira indiscriminada nos acusados, cerceando diversas garantias fundamentais, em destaque a dignidade da pessoa humana e a presunção da inocência. Quanto à condução coercitiva, somente foi proibido o seu uso indiscriminado a partir de 2018 com decisão da Suprema Corte na ADPF n. 395.
Development of a method for isolation of melanin from archival FFPE tissues of human melanoma for structural studies by pyrolysis-gas chromatography-tandem mass spectrometry
Authors: Kurkiewicz Sławomir , Dzierżęga-Lęcznar Anna , Stanek-Widera Agata , Lange Dariusz
Published: April 2022

Introduction

There is some evidence that pheomelanin produced in skin melanocytes may be involved in the development of cutaneous melanoma, particularly in individuals with a light skin/red hair phenotype. However, nothing is known about possible correlation between the type and/or clinical stage of melanoma and the content of pheomelanin in the tumor tissue. We believe that archival formalin-fixed and paraffin-embedded (FFPE) melanoma tissues could be a good source of melanin pigment for future large-scale research on that issue.

Aim

The aim of this work was to develop a method for isolation and purification of melanin from FFPE samples of human melanoma. To test the suitability of the isolation protocol for planned structural studies, the obtained melanin was analyzed for pheomelanin content by the method based on pyrolysis (Py) coupled with gas chromatography and tandem mass spectrometry (GC/MS/MS).

Material and methods

For melanin isolation, microtome sections of FFPE tissue of primary lesion and lymph node metastases were subjected to a multistep procedure of paraffin removal, tissue rehydration, homogenization, and digestion with the set of proteolytic enzymes. The pigment samples were then pyrolyzed at 500 °C, and the GC-separated thermal degradation products were identified using a triple quadrupole mass spectrometer operating in the multiple reaction monitoring mode.

Results

GC/MS/MS analysis of the pyrolysis products revealed the presence of pheomelanin markers, which allowed quantitation of a pheomelanin component of each of the isolated pigments. Melanin from the FFPE primary melanoma was found to contain 6.6%, and the pigment from FFPE metastatic lymph node 7.5% of pheomelanin.

Conclusions

The developed protocol allows for the isolation of melanin from FFPE melanoma specimens. The pigment can be successfully studied for pheomelanin content by Py-GC/MS/MS method. The results of our study indicate that archival FFPE tumor tissues can be used as a good source of melanin for future structural studies aimed at shedding more light on the role of pheomelanin in the pathomechanism of cutaneous melanoma.
Economic Assimilation of Mexicans and Central Americans in the United States1
Authors: Peri Giovanni , Rutledge Zachariah
Published: April 2022

Using United States Census data between 1970 and 2017, we analyze the economic assimilation of subsequent arrival cohorts of Mexicans and Central Americans by comparing their earnings and employment probability to those of natives with similar age and education. We find that, on average, these immigrants started with an earnings gap of 40–45% and eliminated half of it within 20 years of arrival. Recent cohorts that arrived after 1995 performed better than earlier cohorts in that they had smaller initial earnings gaps and faster convergence. Additionally, the most recent cohorts entered the United States without an employment rate disadvantage, and they surpassed natives within 10 years. We also find that Mexicans and Central Americans working in the construction sector and those living in nonenclave and urban areas had faster earnings convergence than the others.
РЕГУЛАЦИОНА СТАНИЦА ГЛАВНОГ ГАСНОГ ТРАНСПОРТНОГ ЧВОРИШТА „ГОСПОЂИНЦИ“
Authors: Кнежевић Весна
Published: April 2022

Предмет рада јесте регулациона станица у оквиру главног гасног транспортног чворишта “Госпођинци”. Услед велике редукције вред­ности притиска гаса поједини елементи регулационе станице се греју, тако да регулациона станица садржи и мерно-регулациону станицу за довођење гаса колтар­ници, котларницу и измењивач топлоте. Циљ рада био је да се димензионише и усвоји опрема регула­ционе станице главног гасног транспортног чворишта „Госпођинци”. Циљ рада реализован је поштовањем законске регулативе Републике Србије. За потребе реализације циља рада коришћен је и Интерни технички правилник за пројектовање и изградњу гасовода и гасоводних објеката на систему ЈП „СРБИЈАГАС“.
KVALITET DIMENZIONALNIH I GEOMETRIJSKIH KARAKTERISTIKA PROIZVODA DOBIJENIH BRIZGANJEM PLASTIKE
Authors: Đukić Saša , Štrbac Branko
Published: April 2022

Proizvod sa zadatim tolerancijama izrade nemoguće je zamisliti bez upotrebe koordinatnih mjernih sistema u procesu verifikacije u fazi razvoja proizvoda. Prema mjerenjima funkcionalnih dimenzija kao specijalnih karakteristika proizvoda prikazana je sposobnost procesa. Ovaj rad je imao za cilj da utvrdi ocijenu kvaliteta dimenzionalnih i geometrijskih karakteristika proizvoda tokom njegovog životnog ciklusa. Rezultati su pokazali da je koordinatni mjerni sistem, uopšteno i mjerni sistem neizostavan segment životnog ciklusa proizvoda.
UTICAJ HABANJA ALATA NA SPEKTAR SIGNALA VIBRACIJA I POPREČNI PRESEK STRUGOTINE
Authors: Zahorec Marina
Published: April 2022

U radu je prikazano eksperimentalno ispitivanje uticaja habanja alata na poprečni presek strugotine i spektar signala vibracija. Mikroskomskom analizom poprečnog preseka strugotine jasno je utvrđen oblik nastale strugotine u korelaciji sa stepenom pohabanosti alata. Tokom procesa obrade praćene su vibracije na nosaču alata, u bliskom području zone rezanja. Analiza generisanih signala vibracija tokom obrade potvrdila je da promene u stepenu habanja alata direktno utiču na oblik strugotine i tip segmentacije.
ПРИМЕНА LEAN МЕТОДОЛOГИЈЕ И BIM-А ПРИ ИЗРАДИ ПРОЈЕКАТА
Authors: Мијатовић Мирко
Published: April 2022

BIM методологија представља иновативно решење при самом приступу изради пројеката. Конципирана је тако да се све одвија у једном централном моделу, коме може свако у сваком тренутку да приступи и осети у реалности како ће неко будуће решење изгледати. Али да би се BIM методологија у потпуности примењивала у процесу израде пројеката, потребно је добро искоординисати и организовати процесе унутар ње. За тај део је задужена LEAN филозофија и њени корисни алати, који су у овом раду примењи и доказано унели побољшање.
МИКРОКЛИМАТСКИ УСЛОВИ У ПУТНИЧКОМ ПРОСТОРУ АУТОБУСА
Authors: Поповић Дејан , Ружић Драган
Published: April 2022

Тема рада су услови топлотног комфора у кабини аутобуса уз утицај клима уређаја. На почетку рада направљен је преглед развоја клима уређаја у аутобусима, наведена су претходна истраживања за побољшање перформанси система, као и начини и примјер испитивања. Обрађени су и сви параметри топлотног комфора.  Урађено је испитивање услова топлотног комфора у кабини аутобуса у стационарном стању. Након испитивања урађено је очитавање резултата, њихова обрада, анализа и поређење са стандардним вриједностима. На крају рада извршена је оцјена резултата, наведени су могући правци даљег истраживања и могућност побољшања.