bluuebunny/crossref_metadata_2025 huggingface dataset:
Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors
Authors: Ao Linjun , van Heemst Diana , Luo Jiao , Teder-Laving Maris , Mägi Reedik , Frikke-Schmidt Ruth , Willems van Dijk Ko , Noordam Raymond
Published: September 2024

The genetic landscape of cardiometabolic risk factors has been explored extensively. However, insight in the effects of genetic variation on these risk factors over the life course is sparse. Here, we performed genome-wide interaction studies (GWIS) on different cardiometabolic risk factors to identify age-specific genetic risks. This study included 270,276 unrelated European-ancestry participants from the UK Biobank (54.2% women, a median age of 58 [interquartile range (IQR): 50, 63] years). GWIS models with interaction terms between genetic variants and age were performed on apolipoprotein B (ApoB), low-density lipoprotein-cholesterol (LDL-C), log-transformed triglycerides (TG), body mass index (BMI) and systolic blood pressure (SBP). Replication was subsequently performed in the Copenhagen General Population Study (CGPS) and the Estonian Biobank (EstBB). Multiple lead variants were identified to have genome-wide significant interactions with age (Pinteraction < 1e − 08). In detail, rs429358 (tagging APOE4) was identified for ApoB (Pinteraction = 9.0e − 14) and TG (Pinteraction = 5.4e − 16). Three additional lead variants were identified for ApoB: rs11591147 (R46L in PCSK9, Pinteraction = 3.9e − 09), rs34601365 (near APOB, Pinteraction = 8.4e − 09) and rs17248720 (near LDLR, Pinteraction = 2.0e − 09). Effect sizes of the identified lead variants were generally closer to the null with increasing age. No variant-age interactions were identified for LDL-C, SBP and BMI. The significant interactions of rs429358 with age on ApoB and TG were replicated in both CGPS and EstBB. The majority of genetic effects on cardiometabolic risk factors remain relatively constant over age, with the noted exceptions of specific genetic effects on ApoB and TG.
Residual Risks of Thrombotic Complications in Anticoagulated Patients with Atrial Fibrillation: A Cluster Analysis Approach from the GLORIA-AF Registry
Authors: Ishiguchi Hironori , Abdul-Rahim Azmil H. , Huang Bi , Lam Steven Ho Man , Liu Yang , Olshansky Brian , Chao Tze-Fan , Huisman Menno V. , Lip Gregory Y. H. ,   on behalf of the GLORIA-AF Investigators
Published: September 2024

Background

Assessment of residual thromboembolic risk in patients with atrial fibrillation (AF) prescribed oral anticoagulants (OACs) remains unexplored. We performed hierarchical cluster analysis to identify phenotypic profiles of these patients and their risks of residual thromboembolic events.

Methods

We utilised data from non-valvular AF patients on OACs, as documented in phases II and III of the GLORIA-AF (Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patients With Atrial Fibrillation) registry. We performed a hierarchical cluster analysis to identify distinct phenotypic profiles. We compared the incidence and risks of thromboembolic events (composite of ischaemic stroke, transient ischaemic attack, or systemic embolism) and related outcomes (major bleeding and all-cause death) across the profiles. We determined the optimal number of profiles through visual inspection of the generated dendrograms.

Results

We included 22,410 patients (mean age 70 ± 8 years; 56% male), from which five phenotypes were identified: profile 1 (“uncontrolled hypertension”), profile 2 (“young with a history of coronary artery disease”), profile 3 (“young and obese”), profile 4 (“frailty”), and profile 5 (“non-paroxysmal AF with tachycardia”). Profile 4 was associated with the highest rates of thromboembolic events (1.66/100 person-years [95% confidence interval, 1.46–1.89]), major bleeding (1.92/100 person-years [1.70–2.16]), and death (6.02/100 person-years [5.62–6.43]). Profile 3 was associated with the lowest risk across all measured outcomes (thromboembolic events, 0.64 events/100 person-years [0.48–0.82]; major bleeding, 0.83 events/100 person-years [0.65–1.04]; and death, 1.44 events/100 person-years [1.21–1.71]). Profile 1 had a moderate thromboembolic event rate (1.04/100 person-years [0.91–1.08]), while profiles 2 and 5 showed lower rates.

Conclusions

The phenotypic profiles of patients with AF prescribed OACs identified using hierarchical cluster analysis are associated with distinct residual thromboembolic risks and related outcomes. This approach has the potential to enhance patient risk-stratification and holistic approaches to management.

Graphical Abstract

AF, atrial fibrillation; CAD, coronary artery disease; F/U, follow-up; HTN, hypertension; IS, ischaemic stroke; NVAF, nonvalvular atrial fibrillation; OACs, oral anticoagulants; PAF, paroxysmal atrial fibrillation; SE, systemic embolism; TE, thromboembolism; TIA, transient ischaemic attack
A Screen of Plant-Based Natural Products Revealed That Quercetin Prevents Pyroglutamylated Amyloid-β (Aβ3(pE)-42) Uptake in Astrocytes As Well As Resulting Astrogliosis and Synaptic Dysfunction
Authors: Arndt Helene , Bachurski Mark , Yuanxiang PingAn , Franke Katrin , Wessjohann Ludger A. , Kreutz Michael R. , Grochowska Katarzyna M.
Published: September 2024

Two connected histopathological hallmarks of Alzheimer’s disease (AD) are chronic neuroinflammation and synaptic dysfunction. The accumulation of the most prevalent posttranslationally modified form of Aβ1–42, pyroglutamylated amyloid-β (Aβ3(pE)-42) in astrocytes is directly linked to glial activation and the release of proinflammatory cytokines that in turn contribute to early synaptic dysfunction in AD. At present, the mechanisms of Aβ3(pE)-42 uptake to astrocytes are unknown and pharmacological interventions that interfere with this process are not available. Here we developed a simple screening assay to identify substances from a plant extract library that prevent astroglial Aβ3(pE)-42 uptake. We first show that this approach yields valid and reproducible results. Second, we show endocytosis of Aβ3(pE)-42 oligomers by astrocytes and that quercetin, a plant flavonol, is effective to specifically block astrocytic buildup of oligomeric Aβ3(pE)-42. Importantly, quercetin does not induce a general impairment of endocytosis. However, it efficiently protects against early synaptic dysfunction following exogenous Aβ3(pE)-42 application.
Evidential Incognizance
Authors: Rippon Simon
Published: September 2024

In this article, I explore an epistemic vice I call “evidential incognizance.” It is a vice of failing generally to recognize evidence, or recognize the full force of evidence, in a domain of knowledge. It frequently manifests as a kind of unbridled skepticism or hopelessness about knowing in the domain, including (but not limited to) skepticism about expert testimony. It is epistemically vicious primarily because it leads people to overlook valuable epistemic opportunities, and thus tends to obstruct knowledge and justified belief. I believe it is of interest particularly because it tends to arise as a reaction to a certain kind of information environment and is often induced intentionally by populist candidates and authoritarian regimes. I discuss the nature of evidential incognizance, its relation to and differences from other epistemic shortcomings, its political significance, why it may have been previously overlooked in the literature, and the potential for overcoming it.
Generative AI and large language models in nuclear medicine: current status and future prospects
Authors: Hirata Kenji , Matsui Yusuke , Yamada Akira , Fujioka Tomoyuki , Yanagawa Masahiro , Nakaura Takeshi , Ito Rintaro , Ueda Daiju , Fujita Shohei , Tatsugami Fuminari , Fushimi Yasutaka , Tsuboyama Takahiro , Kamagata Koji , Nozaki Taiki , Fujima Noriyuki , Kawamura Mariko , Naganawa Shinji
Published: September 2024

This review explores the potential applications of Large Language Models (LLMs) in nuclear medicine, especially nuclear medicine examinations such as PET and SPECT, reviewing recent advancements in both fields. Despite the rapid adoption of LLMs in various medical specialties, their integration into nuclear medicine has not yet been sufficiently explored. We first discuss the latest developments in nuclear medicine, including new radiopharmaceuticals, imaging techniques, and clinical applications. We then analyze how LLMs are being utilized in radiology, particularly in report generation, image interpretation, and medical education. We highlight the potential of LLMs to enhance nuclear medicine practices, such as improving report structuring, assisting in diagnosis, and facilitating research. However, challenges remain, including the need for improved reliability, explainability, and bias reduction in LLMs. The review also addresses the ethical considerations and potential limitations of AI in healthcare. In conclusion, LLMs have significant potential to transform existing frameworks in nuclear medicine, making it a critical area for future research and development.
Dredged Canals, Wetland Loss, and Legacy
Authors: Turner R. Eugene , Ohimain Elijah I.
Published: September 2024

The direct effects of converting coastal wetlands to open water by dredging them can be magnified by indirect effects. For example, dredged canals allow for recovery of mineral fluids 1000 s of m belowground which may induce geological subsidence or faulting; the dredged material deposited at the surface creates levees that redirect overland water flows. These indirect factors may stress wetland plants enough so that additional wetland habitat is converted to open water as a result of longer intervals of wetland soil waterlogging and drying, sulfide toxicity, less organic matter and sediment accumulation, and greater erosion. We quantified the indirect effects by demonstrating a robust dose–response relationship between coastal land loss and canal density in the Mississippi and Niger river deltas over 5 decades. Importantly, the ratio of land loss to canal area increases with time—a legacy effect. Surface impediments to water movements rather than belowground subsidence are the dominant causal factor. We also found that flood protection levees on the main river channel did not significantly magnify the effect of dredging on wetland loss. The cumulative effect of these direct and indirect consequences in coastal Louisiana is enormous and continuing, equaling many tens of billions dollars annually. Understanding these effects supports the rejection of a hypothesis that regional river channel flood protection levees or fluid withdrawal is of greater importance than the local changes in wetland hydrology. Wetland restoration/mitigation of dredging impacts on these two coasts can be implemented at a relatively low cost and quickly if this paradigm of the causes of coastal wetland losses is adopted.
Hemodynamic Analysis in Aortic Dilatation after Arterial Switch Operation for Patients with Transposition of Great Arteries Using Computational Fluid Dynamics
Authors: Park Woo Young , Lee Sang Yun , Seo Jongmin
Published: September 2024

After an arterial switch operation for complete transposition of the great arteries, neo-aortic root dilatation occurs, with unclear hemodynamic effects. This study analyzes three groups (severe dilation, mild dilation, and normal) using computational fluid dynamics (CFD) on cardiac CT scans. Aortic arch angles in severe (median 72.3, range: 68.5–77.2) and mild dilation (76.6, 71.1–85.2) groups are significantly smaller than the normal group (97.3, 87.4–99.0). In the normal and mild dilatation groups, Wall Shear Stress (WSS) exhibits a consistent pattern: it is lowest at the aortic root, gradually increases until just before the bend in the aortic arch, peaks, and then subsequently decreases. However, severe dilation shows disrupted WSS patterns, notably lower in the distal ascending aorta, attributed to local recirculation. This unique WSS pattern observed in severely dilated patients, especially in the transverse aorta. CFD plays an essential role in comprehensively studying the pathophysiology underlying aortic dilation in this population.

Graphical Abstract
Breast cancer drugs: FDA approval, development time, efficacy, clinical benefits, innovation, trials, endpoints, quality of life, value, and price
Authors: Michaeli Julia Caroline , Michaeli Thomas , Trapani Dario , Albers Sebastian , Dannehl Dominik , Würstlein Rachel , Michaeli Daniel Tobias
Published: September 2024

Objective

This study analyzes the development, benefits, trial evidence, and price of new breast cancer drugs with US Food and Drug Administration (FDA) approval.

Methods

We identified 26 drugs with 42 FDA-approved indications for early and metastatic breast cancer (2000–2023). Data were collected from FDA labels, clinicaltrials.gov, and Medicare and Medicaid. Overall survival (OS) and progression-free survival (PFS) hazard ratios (HRs) and tumor response’s relative risk (RR) alongside objective response rate (ORR) were meta-analyzed.

Results

The median development time for breast cancer drugs was 7.8 years (95% CI 6.2–10.8). 26% of treatments were considered innovative (“first-in-indication”) with 88% acting via a targeted mechanism. 64% were small molecules, 19% antibodies, and 18% antibody-drug conjugates. 38% were approved for HR + and 31% for HER2 + breast cancer. 6 indications were for early and 36 for metastatic breast cancer. Indications utilized FDA’s special programs: orphan (2%), fast track (24%), accelerated approval (19%), priority review (74%), breakthrough therapy (44%). Approval was predominantly supported by phase 3 trials (88%) of randomized controlled design (66%), enrolling a median of 585 patients (IQR 417–752) at 181 centers (IQR 142–223) across 19 countries (IQR 17–20). New drugs’ HR were 0.78 for OS (95% CI 0.74–0.82) and 0.59 for PFS (95% CI 0.54–0.64) with a RR for tumor response of 1.61 (95% CI 1.46–1.76). Median improvements of OS were 2.8 months (IQR 1.8–5.8) and PFS were 4.4 months (IQR 2.2–7.1). In single-arm trials, the average ORR was 31% (95% CI 10–53). In meta-regressions, the correlation between OS/PFS was 0.34 (p = 0.031) and OS/response was 0.01 (p = 0.435). 60% of treatments had a ‘high-value’ ESMO-MCBS score with 14% demonstrating improvements in quality of life. The median price was $16,013 per month (95% CI 13,097–17,617). There was no association between prices and patient benefit. The median value per life year gained was $62,419 (IQR 25,840–86,062).

Conclusions

Over the past two decades, the development of innovative and effective drugs transformed the treatment landscape for breast cancer patients. Yet, investigators and regulators must safeguard that highly-priced new drugs demonstrate improvements in patient-centered clinical endpoints: overall survival and quality of life.
Causal relationship between Lipdome and Chronic Obstructive Pulmonary Disease and Asthma: Mendelian randomization
Authors: Wu Qiong , Fu Jingmin , Zhang Cheng , Liu Zhuolin , Shi Jianing , Feng Zhiying , Wang Kangyu , Li Ling
Published: September 2024

Genetic risk significantly influence susceptibility and heterogeneity of chronic obstructive pulmonary disease (COPD) and asthma, and increasing evidence suggests their close association with lipdome. However, their causal relationship remains unclear. In this study, we conducted a two-sample MR (Mendelian randomization) analysis using publicly available large-scale genome-wide association studies (GWAS) data to evaluate the causal impact of lipdome on COPD and asthma. The inverse variance weighted (IVW) method served as the primary analysis method, and multiple sensitivity and heterogeneity tests were performed to assess the reliability of the results. Finally, a Meta-analysis was conducted on lipdome with significant causal relationships to validate the robustness of the results. Our findings suggest that Sterol ester (27:1/18:2), Phosphatidylcholine (15:0_18:2), (16:0_18:2), (16:0_20:2), (17:0_18:2), (18:1_18:1), (18:1_18:2), (18:1_20:2), Triacylglycerol (54:3), and (56:4) levels are protective factors for COPD, while levels of Phosphatidylcholine (16:0_22:5), (18:0_20:4), and (O-16:0_20:4) are risk factors for COPD. Meta-analysis of lipids causally related to COPD also indicates significant results. Phosphatidylcholine (16:0_20:4), (16:0_22:5), and (18:0_20:4) levels are risk factors for asthma, while Phosphatidylcholine (18:1_18:2), (18:1_20:2), and Sphingomyelin (d38:1) levels are protective factors for asthma. However, the lack of statistical significance in the Meta-analysis may be due to heterogeneity in research methods and data statistics. This study indicates that 4 lipdome species have significant correlations with COPD and asthma. Phosphatidylcholine (18:1_18:2) and (18:1_20:2) are protective factors, while Phosphatidylcholine (16:0_22:5) and (18:0_20:4) are risk factors. Additionally, due to differences in molecular subtypes, phosphatidylcholine, sterol ester, and triacylglycerol exhibit differential effects on the diseases.
Oral delivery of stabilized lipid nanoparticles for nucleic acid therapeutics
Authors: Suri Kanika , Pfeifer Liam , Cvet Donna , Li Angela , McCoy Michael , Singh Amit , Amiji Mansoor M.
Published: September 2024

Gastrointestinal disorders originate in the gastrointestinal tract (GIT), and the therapies can benefit from direct access to the GIT achievable through the oral route. RNA molecules show great promise therapeutically but are highly susceptible to degradation and often require a carrier for cytoplasmic access. Lipid nanoparticles (LNPs) are clinically proven drug-delivery agents, primarily administered parenterally. An ideal Orally Delivered (OrD) LNP formulation should overcome the diverse GI environment, successfully delivering the drug to the site of action. A versatile OrD LNP formulation has been developed to encapsulate and deliver siRNA and mRNA in this paper. The formulations were prepared by the systematic addition of cationic lipid to the base LNP formulation, keeping the total of cationic lipid and ionizable lipid to 50 mol%. Biorelevant media stability depicted increased resistance to bile salt mediated destabilization upon the addition of the cationic lipid, however the in vitro efficacy data underscored the importance of the ionizable lipid. Based on this, OrD LNP was selected comprising of 20% cationic lipid and 30% ionizable lipid. Further investigation revealed the enhanced efficacy of OrD LNP in vitro after incubation in different dilutions of fasted gastric, fasted intestinal media, and mucin. Confocal imaging and flow cytometry confirmed uptake while in vivo studies demonstrated efficacy with siRNA and mRNA as payloads. Taken together, this research introduces OrD LNP to deliver nucleic acid locally to the GIT.

Graphical Abstract
Pediatric Clostridioides difficile Infection: Essential Concepts, Management Nuances, and Updates
Authors: Winkie Colin , Gisser Jonathan
Published: September 2024

Purpose of review

AlthoughClostridioides difficile(C. difficile) infection (CDI) is generally considered a healthcare-associated infection, community transmission is more common in children. As such, CDI may be encountered by pediatric generalists and specialists in a variety of clinical settings. Differentiating between colonization and true infection poses a challenge due to overlap of symptoms with other conditions, and variable performance characteristics of available diagnostic tests. Over-diagnosing pediatric CDI can lead to over-treatment and inadvertently to recurrent CDI with implications for community health. This review, therefore, aims to familiarize the practitioner with the nuances of diagnosis and treatment and summarize the most recent advances in the management of pediatric CDI.

Recent findings

Multistep algorithms that utilize PCR- and immunoassay-based tests are increasingly being employed to rapidly detect toxigenic strains ofC. difficileand more reliably differentiate between infection and colonization. Once a true infection is confirmed, a range of treatment options is available including conventional antibiotics like vancomycin, newer antimicrobials such as fidaxomicin, and microbiota-based therapies like fecal microbiota transplantation and novel well-defined bacterial preparations designed to correct dysbiosis. There are also now limited pediatric data regarding Bezlotuxumab, a monoclonal antibody which neutralizesC. difficiletoxin B, preventing recurrence of infection.

Recognizing true CDI in children and selecting the appropriate therapy can be challenging. Understanding the role of microbiota, along with the pathophysiology and risk factors associated with CDI, is crucial for accurate diagnosis, effective treatment, and the prevention of recurrences.
Day-of-the-week effect: a meta-analysis
Authors: Grebe Leonard , Schiereck Dirk
Published: September 2024

This study conducts a meta-analysis on the day-of-the-week effect to shed more light on the replication crisis of this stock market anomaly. The findings confirm that Mondays and Tuesdays provide, on average, lower daily returns. In addition, Wednesdays and Fridays indicate higher returns, with an unexpectedly strong middle-of-the-week effect on Wednesdays. The study highlights the influence of study design on these findings and notes a more substantial effect in the 1980s and 1990s. While differences in empirical methods do not impact the anomaly, index choices affect findings on day-dependent returns. The real estate sector especially stands out with a stronger day-of-the-week effect. However, geographic differences are mostly insignificant except for Oceania. Cultural differences demonstrate a weak but significant effect on abnormal daily returns. From a meta-perspective, outliers remain an essential driver for this stock market anomaly, indicating that study design is not the only factor driving the replication crisis.
Sequential parametrized topological complexity of sphere bundles
Authors: Farber Michael , Paul Amit Kumar
Published: September 2024

Autonomous motion of a system (robot) is controlled by a motion planning algorithm. A sequential parametrized motion planning algorithm [10] works under variable external conditions and generates continuous motions of the system to attain the prescribed sequence of states at prescribed moments of time. Topological complexity of such algorithms measures their structure and discontinuities. Information about states of the system consistent with states of the external conditions is described by a fibration $$p:E\rightarrow B$$

p
:
E
→
B

where the base B parametrizes the external conditions and each fibre $$p^{-1}(b)$$

p

-
1

(
b
)

is the configuration space of the system constrained by external conditions $$b\in B$$

b
∈
B

; more detail on this approach is given below. Our main goal in this paper is to study the sequential topological complexity of sphere bundles $$\dot{\xi }:\dot{E}\rightarrow B$$

ξ
˙

:

E
˙

→
B

; in other words we study “parametrized families of spheres” and sequential parametrized motion planning algorithms for such bundles. We use the Euler and Stiefel–Whitney characteristic classes to obtain lower bounds on the topological complexity. We illustrate our results by many explicit examples. Some related results for the special case $$r=2$$

r
=
2

were described earlier in [13].
Quiet Quitting as Compensatory Respect: Meaningful Work, Recognition, and the Entrepreneurial Ethic
Authors: Corbin Thomas A. , Flenady Gene
Published: September 2024

This paper employs Axel Honneth’s recognition theory to interpret ‘quiet quitting’ – the practice of limiting work efforts to contracted requirements – as a strategic response by workers facing misrecognition in their work environment. Honneth argues that misrecognition in any one of three social spheres (the family, political society, and the workplace) constitutes disrespect and causes psychological harm. While Honneth contends that experiences of disrespect tend to motivate collective “struggles for recognition,” we suggest that quiet quitters present an alternative response to disrespect, individually seeking recognition in other social spheres rather than engaging in collective action. Further, we draw on Honneth to suggest that the contemporary “entrepreneurial” work ethic – the widespread expectation that workers invest emotionally in their work role – can in practice undermine workplace recognition, contributing to quiet quitters’ compensatory emphasis on recognitive relations outside of work. This recognition-theoretical approach extends current discussions around quiet quitting and yields valuable insights for management theory and practice regarding the critical role of genuine employee recognition in promoting individual well-being and meaningful work experiences.
Elucidating the effects of metal transfer modes and investigating the material properties in wire-arc additive manufacturing (WAAM)
Authors: Iqbal Hambal , Ascari Alessandro , Fortunato Alessandro , Liverani Erica
Published: September 2024

Studies have shown the influence of WAAM process parameters on mechanical properties, bead formation, dimensional accuracy, and microstructure. However, metal transfer modes and their interactions with input variables have not been investigated thoroughly. Therefore, short/spray, pulse and double pulse modes were investigated in this study at different current levels. Bead-on-plate trials were conducted by depositing ER70S-6 wire to investigate bead morphology, dilution, microstructure, and hardness. The study was supported by a detailed statistical approach, including analysis of variance (ANOVA) and regression analysis. Similarly, the combined effects of hatch distance and current were studied on bead formation in multi-layer deposits. Moreover, a thin wall and a cubic structure were deposited to realize the WAAM capability for larger depositions. The microstructures of thin wall and cubic structure were analyzed using optical microscopy (OM) and scanning electron microscopy (SEM). The study concludes that metal transfer modes at various currents significantly influence bead geometry, microstructure and hardness. The microstructure of bead-on-plate trials show fine lamellar structure at low current in all modes. Higher current results in coarse grains with a polygonal and columnar morphology. The hardness shows a decreasing trend as the current increases. The combined effects of current and hatch distance alter bead morphology; however, an optimized combination yields smoother surfaces. The microstructure of thin wall showed a slight anisotropy along the building direction. The presence of small pores was witnessed from OM and SEM images. Similarly, the cubic structure showed a more homogeneous microstructure with much lower porosity. The hardness profile of the thin wall exhibited small fluctuations along the building direction, while that of the cubic structure was more uniform.
Experiencing Meaningful Work through Corporate Volunteering: The Other as a Source of Meaning
Authors: Hatami Akram , Glińska-Neweś Aldona , Hermes Jan
Published: September 2024

Global social, ecological and economic crises are contributing to the need for meaningfulness in different spheres of life, including work, as an increasing concern to employees. However, the current understanding of meaningfulness is bound by its normativity and thus does not meet the uncertainty present in today’s work. We utilize the Levinasian concept of “the Other” to provide a non-normative conceptualization of meaningfulness in the context of corporate volunteering (CV) and empirically explore work meaningfulness in CV projects in Poland and Finland. We find work meaningfulness to arise from proximity to the Other and the otherness of the Other. Our study contributes to the discussion on meaningful work in the fields of business ethics and management studies through a non-normative reconceptualization of meaningfulness.
A Methodology to Measure Glucose Metabolism by Quantitative Analysis of PET Images
Authors: Vizza Patrizia , Succurro Elena , Pozzi Giuseppe , Guzzi Pietro Hiram , Cascini Giuseppe Lucio , Tradigo Giuseppe , Veltri Pierangelo
Published: September 2024

Positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) tracer is the standard clinical technique to measure myocardial and vessel metabolism and viability and to investigate the metabolic syndrome associated with cardiovascular diseases. The quantitative analysis of PET images allows one to study the cardiovascular physiological processes, by extracting quantitative parameters from the analysis of the tracer kinetic. Here, we propose a new methodology to quantify and evaluate the evolution of glucose metabolism inside the myocardium and the large vascular structures over time. We merge and analyze PET and CT cardiac images, extracting different volumes of interest (VOI) and performing quantitative measurements. To validate it, we apply the methodology to merge images of the aorta vessel for patients affected by metabolic syndrome. The application of the proposed approach to the use case reveals a correlation between administered drugs and metabolic syndrome, measuring the glucose metabolic rate (MRGlu) in both the myocardium and aorta. The proposed methodology can be used to evaluate some cardiovascular risk indexes of diabetic patients, too. The proposed methodology can also be deployed to analyze other application domains.
Deep learning in Cobb angle automated measurement on X-rays: a systematic review and meta-analysis
Authors: Zhu Yuanpeng , Yin Xiangjie , Chen Zefu , Zhang Haoran , Xu Kexin , Zhang Jianguo , Wu Nan
Published: September 2024

Purpose

This study aims to provide an overview of different deep learning algorithms (DLAs), identify the limitations, and summarize potential solutions to improve the performance of DLAs.

Methods

We reviewed eligible studies on DLAs for automated Cobb angle estimation on X-rays and conducted a meta-analysis. A systematic literature search was conducted in six databases up until September 2023. Our meta-analysis included an evaluation of reported circular mean absolute error (CMAE) from the studies, as well as a subgroup analysis of implementation strategies. Risk of bias was assessed using the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). This study was registered in PROSPERO prior to initiation (CRD42023403057).

Results

We identified 120 articles from our systematic search (n = 3022), eventually including 50 studies in the systematic review and 17 studies in the meta-analysis. The overall estimate for CMAE was 2.99 (95% CI 2.61–3.38), with high heterogeneity (94%, p < 0.01). Segmentation-based methods showed greater accuracy (p < 0.01), with a CMAE of 2.40 (95% CI 1.85–2.95), compared to landmark-based methods, which had a CMAE of 3.31 (95% CI 2.89–3.72).

Conclusions

According to our limited meta-analysis results, DLAs have shown relatively high accuracy for automated Cobb angle measurement. In terms of CMAE, segmentation-based methods may perform better than landmark-based methods. We also summarized potential ways to improve model design in future studies. It is important to follow quality guidelines when reporting on DLAs.
The role of the cryosphere for runoff in a highly glacierised alpine catchment, an approach with a coupled model and in situ data
Authors: Lambrecht Astrid , Mayer Christoph
Published: September 2024

Runoff from heavily glacierised catchments, its seasonality and the contribution from different storage units are highly relevant for assessing the seasonal and long-term water supply and flood prediction. Modelling studies on runoff from such basins often use simulated meteorological input (e.g. downscaling products) based on remote observations. We investigate the contribution of snow, firn and ice to runoff in the Vernagtferner basin (Ötztal Alps) from 2020 to 2022, using a physical modelling chain driven by a local observation network. We use the SNOWPACK model to simulate snow/ice development at observation sites and the Alpine3D model to calculate accumulation and melt at the catchment scale. Basin discharge is estimated using a gridded version of the HBV-ETH model. This approach largely reproduces observed glacier mass balances, while modelled and measured basin discharge are in good agreement. Snowmelt dominates discharge in the early melt season, while ice melt becomes increasingly important during summer. This is in strong contrast to the near-equilibrium mass balances in the 1980s, when ice melt played a minor role for annual discharge. The strong reduction of the accumulation area leads to a fundamental change from a snowmelt regime to an ice melt regime, which is especially pronounced in 2022.
Dynamics of Intermarriage in Europe
Authors: Lendák-Kabók Karolina , Örkény Antal
Published: September 2024

This article analyses the scholarly results concerning the social phenomenon of intermarriage. It specifically focuses on the similarities and differences in the latter in Europe, between migrants and host society members, and between national minorities and majorities. The study shows that while intermarriage between migrants and host society members is often seen as a vehicle for bridging social gaps and promoting social cohesion, intermarriages between national minorities and majorities is more likely to lead to erosion of minority identities and cultural traits. Common challenges faced by intermarried couples include resistance from family members and bureaucratic obstacles, with gender dynamics playing a crucial role, particularly in traditional societies where women often bear the brunt of cultural assimilation. Intermarriage also promotes the perspective of the integrative nature of nation-states without requiring intervention by the states themselves. The article underscores the importance of deepening the discourse on intermarriage and focusing on the impact of the latter on both migrant and national minority communities through both quantitative analyses and qualitative approaches. This may improve the understanding of the transformative potential and challenges of these unions.
Slovak National Communism in Interwar Czechoslovakia
Authors: Benko Juraj , Hudek Adam
Published: September 2024

Slovak national communism as a specific approach to the problem of Czech-Slovak relations gained a significant position within the Communist Party of Czechoslovakia soon after its establishment in 1921. This article analyzes the foundations of this phenomenon and the evolving attitudes of the first generation of Slovak communist intellectuals and Party functionaries. The article’s primary focus is on the Slovak communists’ views regarding the official state doctrine of a unified Czechoslovak nation, Czech-Slovak relations, and the issue of Slovak autonomy. The study highlights the significant external influences, particularly the directives of the Communist International and the pre-existing national stereotypes, that shaped the worldview and nationalist tendencies of Slovak communists.
The future backbone of nutritional science: integrating public health priorities with system-oriented precision nutrition
Authors: Vergères Guy , Bochud Murielle , Jotterand Chaparro Corinne , Moretti Diego , Pestoni Giulia , Probst-Hensch Nicole , Rezzi Serge , Rohrmann Sabine , Brück Wolfram M.
Published: September 2024

Adopting policies that promote health for the entire biosphere (One Health) requires human societies to transition towards a more sustainable food supply as well as to deepen the understanding of the metabolic and health effects of evolving food habits. At the same time, life sciences are experiencing rapid and groundbreaking technological developments, in particular in laboratory analytics and biocomputing, placing nutrition research in an unprecedented position to produce knowledge that can be translated into practice in line with One Health policies. In this dynamic context, nutrition research needs to be strategically organised to respond to these societal expectations. One key element of this strategy is to integrate precision nutrition into epidemiological research. This position article therefore reviews the recent developments in nutrition research and proposes how they could be integrated into cohort studies, with a focus on the Swiss research landscape specifically.
Parasitic behaviour and developmental morphology of Anastatus japonicus reared on the factitious host Antheraea pernyi
Authors: Wang Run-Zhi , Chen Xu , Tariq Talha , Lv Rui-E , Chen Yong-Ming , Zang Lian-Sheng
Published: September 2024

The egg parasitoid Anastatus japonicus is a key natural enemy in the biological control of various agricultural and forestry pests. It is particularly used against the brown marmorated stink bug Halyomorpha halys and the emerging defoliator pest Caligula japonica in East Asia. It has been proved that the eggs of Antheraea pernyi can be used as a factitious host for the mass production of A. japonicus. This study systematically documented the parasitic behaviour and developmental morphology exhibited by A. japonicus on the eggs of A. pernyi. The parasitic behaviour of A. japonicus encompassed ten steps including searching, antennation, locating, digging, probing, detecting, oviposition, host-feeding, grooming, and resting. Oviposition, in particular, was observed to occur in three stages, with the parasitoids releasing eggs during the second stage when the body remained relatively static. Among all the steps of parasitic behaviour, probing accounted for the longest time, constituting 33.1% of the whole time. It was followed by digging (19.3%), oviposition (18.5%), antennation (9.6%), detecting (7.4%), and the remaining steps, each occupying less than 5.0% of the total event time. The pre-emergence of adult A. japonicus involves four stages: egg (0 to 2nd day), larva (3rd to 9th day), pre-pupa (10th to 13th day), pupa (14th to 22nd day), and subsequent development into an adult. Typically, it takes 25.60 ± 0.30 days to develop from an egg to an adult at 25℃. This information increases the understanding of the biology of A. japonicus and may provide a reference for optimising reproductive devices.
Negotiating power: Disputes over electrification in rural India
Authors: Roy Indrajit
Published: September 2024

How are infrastructures socially appropriated? This article uses my fortuitous presence in a rural locality in eastern India as its residents discussed proposals for its complete electrification, allowing me to reflect on social negotiations around infrastructure prior to its installation. Drawing on a detailed ethnography of electrification in a West Bengal village, I illustrate the nuanced ways in which people inflect infrastructural projects with their collective ideas of what is right and good. As far as they can see, such projects are neither the unalloyed benefit that proponents celebrate nor the unmitigated evil that opponents lament. Rather, they are evaluated in relation to people’s imagination of the collective good, to which such infrastructures may or may not be central. Drawing on the insights offered by my interlocutors as well as recent advances in the literature on the politics of infrastructures, this article interrogates the perspective that infrastructures advance governmental rationalities. Building on well-established insights that technological infrastructures are not socially neutral and that infrastructures are socially appropriated, disputed, and negotiated, this article demonstrates that people’s engagement with infrastructures politicizes, rather than governmentalizes, them.
Large-bodied gastric spirurids (Nematoda, Spirurida) predict structure in the downstream gastrointestinal helminth community of wild spiny mice (Acomys dimidiatus)
Authors: Behnke Jerzy M. , Jackson Joseph A. , Gilbert Francis , Mohallal Eman M. E. , Bajer Anna
Published: September 2024

The dominant helminths infecting spiny mice (Acomys dimidiatus) in the montane wadis of the Sinai Peninsula of Egypt are spirurid nematodes, notably Protospirura muricola and Mastophorus muris. Both are relatively large robust stomach worms that accumulate in hosts resulting in high worm burdens. To ascertain whether the presence of spirurid worms or their burdens alters the host's likelihood of infection with other helminth species, we analysed a database containing quantitative data on helminth parasites of these mice (n = 431). This comprised of worm burdens recorded during 4 surveys, conducted at 4-year intervals, in 4 wadis, during late summer of each year. The presence of spirurid worms did not significantly alter species richness with other helminth species nor the likelihood of mice carrying other nematode species. However, there was a significant association, particularly of P. muricola, with the presence of intestinal stages of cestodes, and with the acanthocephalan Moniliformis acomysi. After controlling for intrinsic and extrinsic factors, mice harbouring spirurid worms had greater worm burdens of other helminths compared with mice without spirurids. Moreover, spirurid worm burdens showed a significant positive covariation with similarly adjusted species richness of other helminths, non-spirurid helminths, non-spirurid nematodes, oxyuroid nematodes and intestinal stage cestode worm burdens. We interpret these results as an indication that the key driver for co-occurrence of spirurids with other helminths is likely to be transmission via common arthropod hosts (for cestodes and acanthocephalans), but also that mice carrying the heavier spirurid worm burdens become more susceptible to directly transmitted nematodes such as the Oxyuroidea.
Undetected suicide attempts among U.S. soldiers: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)
Authors: Naifeh James A. , Ursano Robert J. , Shor Rachel , Mash Holly B. Herberman , Aliaga Pablo A. , Fullerton Carol S. , Nock Matthew K. , Kao Tzu-Cheg , Sampson Nancy A. , Kessler Ronald C. , Stein Murray B.
Published: September 2024

Background

While previous studies have reported high rates of documented suicide attempts (SAs) in the U.S. Army, the extent to which soldiers make SAs that are not identified in the healthcare system is unknown. Understanding undetected suicidal behavior is important in broadening prevention and intervention efforts.

Methods

Representative survey of U.S. Regular Army enlisted soldiers (n = 24 475). Reported SAs during service were compared with SAs documented in administrative medical records. Logistic regression analyses examined sociodemographic characteristics differentiating soldiers with an undetected SA v. documented SA. Among those with an undetected SA, chi-square tests examined characteristics associated with receiving a mental health diagnosis (MH-Dx) prior to SA. Discrete-time survival analysis estimated risk of undetected SA by time in service.

Results

Prevalence of undetected SA (unweighted n = 259) was 1.3%. Annual incidence was 255.6 per 100 000 soldiers, suggesting one in three SAs are undetected. In multivariable analysis, rank ⩾E5 (OR = 3.1[95%CI 1.6–5.7]) was associated with increased odds of undetected v. documented SA. Females were more likely to have a MH-Dx prior to their undetected SA (Rao-Scott χ21 = 6.1, p = .01). Over one-fifth of undetected SAs resulted in at least moderate injury. Risk of undetected SA was greater during the first four years of service.

Conclusions

Findings suggest that substantially more soldiers make SAs than indicated by estimates based on documented attempts. A sizable minority of undetected SAs result in significant injury. Soldiers reporting an undetected SA tend to be higher ranking than those with documented SAs. Undetected SAs require additional approaches to identifying individuals at risk.
When and how patients' self-claims are challenged in psychotherapy
Authors: Peräkylä Anssi , Voutilainen Liisa , Wuolio Mariel , Deppermann Arnulf
Published: September 2024

The article describes the practices through which patients’ self-presentations are challenged in psychotherapy. Based on the analysis of thirty-eight instances from psychodynamic psychotherapy and psychoanalysis, analyzed with methods of conversation analysis, narrative analysis, and coding, this article reports on how therapists challenge patients’ self-conceptualizations in response to patients’ self-presentations. Challenges mostly follow patients’ descriptive, narrative, or evaluative accounts that include a strong claim about their self. Challenges to the self pertain to core issues of the therapeutic projects. They are mostly built in ways that show its sensitivity to probable rejection by the patient. Overwhelmingly, the challenge is accounted for by reference to shared knowledge built in the participants’ shared interactional history. Arguably, psychotherapy is a particular setting where the organization of face-work is modified, as occasional challenging of the co-interactant's self-presentation is part of the institutional task of the professional participant. Data are in Finnish and German. (Self, psychotherapy, Goffman, conversation analysis)*
Bundled otherwise: Skills, social mobility, and raciolinguistic ideologies in the Canadian labour market
Authors: McLaughlin Mireille
Published: September 2024

Showcasing how understandings of social mobility encoded raciolinguistic ideologies of the ideal upwardly mobile speaker, I investigate blue- and white-collar orientation to language, race, and social mobility in the Canadian labor market. I analyze these two subject positionalities and the way bundles of skills are ‘bundled otherwise’ when ideologies of race and language are invoked as relevant to a class experience. While the acquisition of standard languages remains understood as a gateway to upward mobility, the increased commodification of language made the acquisition of standard registers of French and English a skill amongst others, on par with any other. If this shift challenges an implicit ‘linguistic’ bias embedded in emic and scientific understandings of class, raciolinguistic ideologies continue to organize worker's orientations to language and work, be it to imagine themselves as cosmopolitan workers or to defend the positions of ethnic, national, and racialized groups in the economy. (Social class, raciolinguistics, work, language ideologies, francophone Canada, bilingualism)*
Diagnosis on the implementation of the New Urban Agenda
Authors: Diaz-Sarachaga Jose Manuel , Longo Sarachaga Joana
Published: September 2024

Non-technical summary

Rapid population growth in urban areas requires an effective transposition of sustainable development goals to the urban realm, for which the New Urban Agenda was adopted by most countries worldwide. The progress report of its implementation was discussed in this study to identify strengths and weaknesses in the process that assist nations in the design and application of effective actions to achieve a more sustainable urban development.

Technical summary

The adoption of the 2030 Agenda represents a daunting challenge for countries worldwide, which found its continuation in the New Urban Agenda (NUA) geared predominantly toward urban settlements. Although the achievement of the sustainable development goals (SDGs) has been widely monitored by global and national institutions, the progress of the NUA has not been properly addressed to date. With the purpose of filling this gap, this study aims to gauge the implementation level of the NUA through the analysis of all status reports issued hitherto by countries, on the basis of the reporting template designed to this effect by the United Nations. Findings revealed the scarce attention paid to report national progress on the application of the NUA, particularly marked in the most developed economies. Reporting guidelines showed a poor coverage of the SDGs, being mostly focused on a limited number of these as well as the institutional and economic dimensions. The low level of NUA implementation and the questionable effectiveness of the reporting framework for monitoring are main conclusions. Some recommendations were lastly suggested to enhance the application process of the NUA.

Social media summary

Most countries worldwide show little interest in the application of the New Urban Agenda.