bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of the Dynamics of Agglomeration Externalities on Air Pollution: Evidence from Urban Panel Data in China
Authors: Tan Xiaolan , Yu Wentao , Wu Shiwei
Published: January 2022

Air pollution in China has become a matter of increasing public concern. In this paper, we attempted to build a theoretical model to explore the impact of the dynamics of agglomeration externalities on haze pollution in urban China, where agglomeration is differentiated by regional specialization and geographical concentration. Based on China’s panel data for 289 cities during the period of 1998–2018, the empirical result shows that the relationship between industrial agglomeration and urban haze pollution is not simply linear or of an inversed U-type but turns out to be dynamically N-shaped. To be specific, the increase in local haze pollution can be explained by agglomeration externalities in the beginning stage, whereas the reducing effect only occurs during the mature stage. The heterogeneity test indicated that the effect of the type of agglomeration on haze pollution seems to be mixed in different groups of cities, but is still consistent with the hypothesis of the dynamic change of agglomeration externalities. The results are found to be quite robust and consistent after replacing variables and using other regression methods. This paper provides answers to the question of how to coordinate the relationship between developing industry parks and air pollution in terms of the life cycle of agglomeration as well as the types of city.
Supervisor Bottom-Line Mentality and Knowledge Hiding: A Moderated Mediation Model
Authors: Li Zhen , Cheng Yanyuan
Published: January 2022

Organizations need to respond to multiple demands, not only of shareholders but of stakeholders. Supervisor mentality that focuses on bottom-line goals, such as financial performance, can result in negative consequences. We used conservation of resources theory to examine how and when employees engage in knowledge hiding toward coworkers was influenced by supervisor bottom-line mentality. A two-wave survey (N = 274) revealed a positive impact of supervisor bottom-line mentality on knowledge hiding toward coworkers via prevention-based psychological ownership. Further, the higher the competitive psychological climate, the stronger the positive relationship between supervisor bottom-line mentality and knowledge hiding via prevention-based psychological ownership. Our study highlights the negative effect of supervisor bottom-line mentality on knowledge transfer among employees.
Hybrid Finite-Discrete Element Modelling of Various Rock Fracture Modes during Three Conventional Bending Tests
Authors: An Huaming , Wu Shunchuan , Liu Hongyuan , Wang Xuguang
Published: January 2022

The numerical techniques for modelling the rock fracture have been briefly reviewed. A hybrid finite-discrete element method (HFDEM) is proposed to simulate various fracture types of rock. A fracture model is implemented in the HFDEM for simulation of the three main fracture types. In addition, the influence of the strain rate is considered during the HFDEM modelling rock behavior. Then, two typical rock mechanism tests are employed to calibrate the HFDEM. The proposed method has well modelled the rock fracture processes and can obtain reasonable stress distribution and force–displacement curves. After that, the HFDEM is used to model three convention bending tests. The obtained rock fracture processes indicates that the HFDEM can simulate various fracture types. The obtained rock strengths and fracture toughness indicate that the HFDEM can reflect the influence of the strain rate. It is concluded that the HFDEM can model the entire and complete rock fracture process during the three convention bending tests, and it also can capture the rock’s behavior on the strain rate.
A Mobile System for the On-Site Assembly of Timber Frame Components: The Development of an Agile, Low-Cost Alternative to Offsite Prefabrication
Authors: Gee Stuart , Brown Andre
Published: January 2022

Prefabricated timber component-based systems are the most prevalent industrialised system used to build housing. Along with many other countries, the UK has invested in different types of factory-based prefabrication systems as a means of increasing productivity and enhancing quality. In more recent decades, prefabrication has become part of a series of ‘modern methods of construction’ employed for, and aimed at, delivering sustainable and efficient construction. However, certain pragmatic issues remain. The industry is cyclical, and during periods of declining resources, skills and technical development can be lost. Additionally, factory-based prefabrication requires substantial initial investment and an appropriate local workforce. To help address these issues, this paper presents the concept of an alternative method of production and assembly that takes a different approach to traditional industrialised systems that involve large investments and fixed-location factories. The proposition presented in this paper is that it is possible to design and develop a small, low cost, portable micro-factory that can be taken to a temporary location or construction site, where it can then be used to construct prefabricated closed panels. We describe the development of a working prototype, effectively a micro-factory, along with its potential advantages over a fixed facility.
Biogenic Synthesis of Silver Nanoparticles, Characterization and Their Applications—A Review
Authors: Raj Shani , Trivedi Rohini , Soni Vineet
Published: January 2022

With the growing awareness for the need of sustainable environment, the importance of synthesizing and the application of green nanoparticles has gained special focus. Among various metal nanoparticles, silver nanoparticles (AgNPs) have gain significant attention. AgNPs are synthesized conventionally by physical and chemical methods using chemicals such as reducing agents, which are hazardous to environment due to their toxic properties, provoking a serious concern to create and develop environment friendly methods. Thus, biological alternatives are emerging to fill gaps, such as green syntheses that use biological molecules taken from plant sources in the form of extracts, which have shown to be superior to chemical and physical approaches. These biological molecules derived from plants are assembled in a highly regulated manner to make them suitable for metal nanoparticle synthesis. The current review outlines the wide plant diversity that may be used to prepare a rapid and single-step procedure with a green path over the traditional ones, as well as their antifungal activity.
Evaluating the Ability of Bone Char/nTiO2 Composite and UV Radiation for Simultaneous Oxidation and Adsorption of Arsenite
Authors: Alkurdi Susan , Al-Juboori Raed , Bundschuh Jochen , Marchuk Alla
Published: January 2022

The reuse of waste materials for water treatment purposes is an important approach for promoting the circular economy and achieving effective environmental remediation. This study examined the use of bone char/titanium dioxide nanoparticles (BC/nTiO2) composite and UV for As(III) and As(V) removal from water. The composite was produced via two ways: addition of nTiO2 to bone char during and after pyrolysis. In comparison to the uncoated bone char pyrolyzed at 900 °C (BC900), nTiO2 deposition onto bone char led to a decrease in the specific surface area and pore volume from 69 to 38 m2/g and 0.23 to 0.16 cm3/g, respectively. However, the pore size slightly increased from 14 to 17 nm upon the addition of nTiO2. The composite prepared during pyrolysis (BC/nTiO2)P had better As removal than that prepared after pyrolysis with the aid of ultrasound (BC/nTiO2)US (57.3% vs. 24.8%). The composite (BC/nTiO2)P had higher arsenate oxidation than (BC/nTiO2)US by about 3.5 times. Arsenite oxidation and consequent adsorption with UV power of 4, 8 and 12 W was examined and benchmarked against the composite with visible light and BC alone. The highest UV power was found to be the most effective treatment with adsorption capacity of 281 µg/g followed by BC alone (196 µg/g). This suggests that the effect of surface area and pore volume loss due to nTiO2 deposition can only be compensated by applying a high level of UV power.
Stability Assessment of Rock Mass System under Multiple Adjacent Structures
Authors: Kim Bo Sung , Lee Joon Kyu
Published: January 2022

Numerical modeling is important for exploring the fundamental processes occurring in rock and for evaluating the real performance of structures built on and in rock mass system, and thus for supporting the design of rock engineering problems. Estimating the stability of rock mass foundation systems entirely based on a theoretical approach is a complicated task if there exists overlapping of their potential collapse modes. This paper applies finite element limit analysis to evaluate the bearing capacity of equally spaced multiple strip footings resting on rock mass obeying the modified non-linear Hoek–Brown failure criterion. Numerical solutions are expressed in terms of the efficiency factor that is dependent on the spacing between footings, as well as the rock mass properties. In addition, the effects of surface surcharge and footing roughness are quantified. The maximum spacing at which the interfering effect of adjacent footings becomes disappeared is evaluated and an algebraic expression for approximating the maximum spacing is proposed. Failure mechanisms for a few cases of rock mass under multiple strip footings are examined.
The Influence of Farmers’ Socio-Economic Characteristics on Their Choice of Opinion Leaders: Social Knowledge Systems
Authors: Tamako Nthabeleng , Chitja Joyce , Mudhara Maxwell
Published: January 2022

Smallholder farmers’ social knowledge systems are evolving in connecting key actors within and outside their knowledge systems. These key actors play a vital role in navigating the complexity and the dynamics of organisations, and effectively influence the community. This study identified the opinion leaders of smallholder farmers and measured the extent of their influence on the quality of these farmers’ knowledge of agriculture. Furthermore, the study explored the reasons why farmers choose their opinion leaders. A structured questionnaire was administered to 219 purposively selected smallholder farmers in the rural areas in KwaZulu-Natal, South Africa. Data were captured and analysed using the Statistical Package for Social Sciences (SPSS) version 26 and STATA to run multinomial logistic regression model (MNL). The results showed that farmers participated in field visits and attended farmers’ group meetings to communicate with agricultural advisors and group leaders. In addition, the findings showed that interactions could be a crucial element of knowledge and learning for farmers. This showed that the farmers required a consistent flow of material resources and knowledge. The time and energy spent by farmers building social relationships with these opinion leaders reflected the accumulation of information and resources gathered. Issues related to accessibility, availability and, quick feedback regarding farmers’ problems emerged, which seemed to influence the farmers’ choice of an opinion leader. The language and accessibility to sources of knowledge and feedback were crucial to the smallholder farmers included in the study. Furthermore, the results revealed that farmers’ educational level, farmers who engaged in agriculture for household consumption, and opinion agricultural skills have statistical significance on farmers’ choice of opinion leaders. Considering the findings, it is suggested that efforts to improve farmers’ active knowledge systems and access to the opinion leaders within these active knowledge systems should take into consideration the socio-economic factors that influence farmers’ choices and participation in social systems and social interactions. These findings may help agents develop a better understanding of the dynamics of local communities and the social complexity that shapes farmers’ environments and decisions. To be a progressive and effective opinion leader, constant, continuous assessment is needed to increase leadership skills. In addition, the enhancement of programmes, which will recognise the active opinion leaders within the communities, are needed to strengthen the efforts and impact for more resilient outcomes.
XGB-RF: A Hybrid Machine Learning Approach for IoT Intrusion Detection
Authors: Faysal Jabed Al , Mostafa Sk Tahmid , Tamanna Jannatul Sultana , Mumenin Khondoker Mirazul , Arifin Md. Mashrur , Awal Md. Abdul , Shome Atanu , Mostafa Sheikh Shanawaz
Published: January 2022

In the past few years, Internet of Things (IoT) devices have evolved faster and the use of these devices is exceedingly increasing to make our daily activities easier than ever. However, numerous security flaws persist on IoT devices due to the fact that the majority of them lack the memory and computing resources necessary for adequate security operations. As a result, IoT devices are affected by a variety of attacks. A single attack on network systems or devices can lead to significant damages in data security and privacy. However, machine-learning techniques can be applied to detect IoT attacks. In this paper, a hybrid machine learning scheme called XGB-RF is proposed for detecting intrusion attacks. The proposed hybrid method was applied to the N-BaIoT dataset containing hazardous botnet attacks. Random forest (RF) was used for the feature selection and eXtreme Gradient Boosting (XGB) classifier was used to detect different types of attacks on IoT environments. The performance of the proposed XGB-RF scheme is evaluated based on several evaluation metrics and demonstrates that the model successfully detects 99.94% of the attacks. After comparing it with state-of-the-art algorithms, our proposed model has achieved better performance for every metric. As the proposed scheme is capable of detecting botnet attacks effectively, it can significantly contribute to reducing the security concerns associated with IoT systems.
Aromatherapy in Textiles: A Systematic Review of Studies Examining Textiles as a Potential Carrier for the Therapeutic Effects of Essential Oils
Authors: Mehta Sunidhi , MacGillivray Maureen
Published: January 2022

Integrative medicine is a rapidly growing specialty field of medical care that emphasizes the amalgamation of complementary therapies and conventional medicine. Aromatherapy, one of the complementary therapies, is a centuries-old tradition, used in many cultures and societies as an alternative to, or in conjunction with, conventional medicine. However, there is very little understanding of its therapeutic benefits in the scientific realm related to the correct dosage of essential oils, their delivery mechanism and their efficacy on human physiology in general. We reviewed studies published between 2011–2021 focused on aromatherapy and textiles, and explore “textile” materials as a possible carrier for essential oils in this paper. Due to their proximity to the biggest organ of the human body, textiles can potentially serve as a good delivery system for the therapeutic benefit of essential oils. After this rigorous review, we found gaps in the field. Therefore, we propose cross-disciplinary synergies for future research to fully understand the therapeutic efficacy of essential oils.
Microscopic Fractional Anisotropy Detects Cognitive Training-Induced Microstructural Brain Changes
Authors: Li Xinnan , Sawamura Daisuke , Hamaguchi Hiroyuki , Urushibata Yuta , Feiweier Thorsten , Ogawa Keita , Tha Khin Khin
Published: January 2022

Cognitive training-induced neuroplastic brain changes have been reported. This prospective study evaluated whether microscopic fractional anisotropy (μFA) derived from double diffusion encoding (DDE) MRI could detect brain changes following a 4 week cognitive training. Twenty-nine healthy volunteers were recruited and randomly assigned into the training (n = 21) and control (n = 8) groups. Both groups underwent brain MRI including DDE MRI and 3D-T1-weighted imaging twice at an interval of 4–6 weeks, during which the former underwent the training. The training consisted of hour-long dual N-back and attention network tasks conducted five days per week. Training and time-related changes of DDE MRI indices (μFA, fractional anisotropy (FA), and mean diffusivity (MD)) and the gray and white matter volume were evaluated using mixed-design analysis of variance. In addition, any significant imaging indices were tested for correlation with cognitive training-induced task performance changes, using partial correlation analyses. μFA in the left middle frontal gyrus decreased upon the training (53 voxels, uncorrected p < 0.001), which correlated moderately with response time changes in the orienting component of attention (r = −0.521, uncorrected p = 0.032). No significant training and time-related changes were observed for other imaging indices. Thus, μFA can become a sensitive index to detect cognitive training-induced neuroplastic changes.
Mimics and Pitfalls of Primary Ovarian Malignancy Imaging
Authors: Elsherif Sherif B. , Agely Ali , Gopireddy Dheeraj R. , Ganeshan Dhakshinamoorthy , Hew Karina E. , Sharma Smita , Lall Chandana
Published: January 2022

The complex anatomy and similarity of imaging features of various pathologies in the pelvis can make accurate radiology interpretation difficult. While prompt recognition of ovarian cancer remains essential, awareness of processes that mimic ovarian tumors can avoid potential misdiagnosis and unnecessary surgery. This article details the female pelvic anatomy and highlights relevant imaging features that mimic extra-ovarian tumors, to help the radiologists accurately build a differential diagnosis of a lesion occupying the adnexa.
SPECT/CT Assessment of In-Vivo Loading of the Knee Correlates with Polyethylene Deformation in Retrieved Total Knee Arthroplasty
Authors: Hothi Harry , Cerquiglini Arianna , Büel Lukas , Henckel Johann , Moser Lukas B. , Hirschmann Michael T. , Hart Alister
Published: January 2022

Background: SPECT/CT distribution patterns in patients with total knee replacements have previously been correlated with factors such as time of implantation, implant type and alignment. It is unknown, however, if an increased and more extended bone tracer uptake (BTU) in SPECT/CT, representing loading of the joint, correlates with findings from retrieval studies. The aim of this study was to further understand this subject. Materials and Methods: 62 retrieved TKA were included. SPECT/CT was performed prior to revision. Quantitative and qualitative medio-lateral comparisons of BTU intensity and distribution in the tibia were performed. Retrieval analysis was performed with a micro-CT method to assess the thickness differences between medial and lateral sides of polyethylene inserts with symmetrical designs. Results: In the subgroup of TKA with asymmetrical SPECT/CT distribution, there was a significant correlation between retrieval and medical imaging data (p = 0.0355): patients showing a more extended BTU in the medial compartment also had a significantly thinner insert in the medial compartment, and vice versa in the lateral side. Conclusion: This is the first study comparing BTU distribution patterns and retrieval findings. Our results support the hypothesis that SPECT/CT is able to identify bone activity due to implant position and loading.
Comparative Assessment of Antibiotic Residues Using Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC-MS/MS) and a Rapid Screening Test in Raw Milk Collected from the North-Central Algerian Dairies
Authors: Meklati Fawzi Rostane , Panara Anthi , Hadef Ahmed , Meribai Amel , Ben-Mahdi Meriem H. , Dasenaki Marilena E. , Thomaidis Nikolaos S.
Published: January 2022

Antibiotic residues in milk are a major health threat for the consumer and a hazard to the dairy industry, causing significant economic losses. This study aims to assess the presence of antibiotic residues in raw milk comparatively by a rapid screening test (BetaStar® Combo) and Liquid Chromatography coupled with Tandem Mass Spectrometry (LC-MS/MS). A total of 445 samples were collected from 3 dairy companies of north-central Algeria (Algiers, Blida, Boumerdes), and they were rapidly screened for β-lactams and tetracyclines; 52 samples, comprising 34 positive tanker-truck milk and 18 negative bulk-tank milk were tested by LC-MS/MS, which revealed 90.4% were contaminated (n = 47) and 55.3% exceeded the Maximum Residue Limit (MRL). The β-lactams as parent compounds and their metabolites were the most frequently detected with maximum value for cloxacillin (1231 µg/kg) and penicillin G (2062 µg/kg). Under field condition, the false-positive results, particularly for tetracyclines, seems to be related to milk samples displaying extreme acidity values (≥19°D) or fat-level fluctuations (2.7 g/100 mL and 5.6–6.2 g/100 mL). Despite a relatively low prevalence (7.64%) of residues using the rapid test, the detection by LC-MS/MS of flumequine (52 µg/kg), cefaclor (maximum 220 µg/kg) and metabolites of β-lactams at high levels should lead to reflections on the control of their human and environmental toxicological effects.
Urban Neighbourhood Environments, Cardiometabolic Health and Cognitive Function: A National Cross-Sectional Study of Middle-Aged and Older Adults in Australia
Authors: Cerin Ester , Barnett Anthony , Shaw Jonathan , Martino Erika , Knibbs Luke , Tham Rachel , Wheeler Amanda , Anstey Kaarin
Published: January 2022

Population ageing and urbanisation are global phenomena that call for an understanding of the impacts of features of the urban environment on older adults’ cognitive function. Because neighbourhood characteristics that can potentially have opposite effects on cognitive function are interdependent, they need to be considered in conjunction. Using data from an Australian national sample of 4141 adult urban dwellers, we examined the extent to which the associations of interrelated built and natural environment features and ambient air pollution with cognitive function are explained by cardiometabolic risk factors relevant to cognitive health. All examined environmental features were directly and/or indirectly related to cognitive function via other environmental features and/or cardiometabolic risk factors. Findings suggest that dense, interconnected urban environments with access to parks, blue spaces and low levels of air pollution may benefit cognitive health through cardiometabolic risk factors and other mechanisms not captured in this study. This study also highlights the need for a particularly fine-grained characterisation of the built environment in research on cognitive function, which would enable the differentiation of the positive effects of destination-rich neighbourhoods on cognition via participation in cognition-enhancing activities from the negative effects of air pollutants typically present in dense, destination-rich urban areas.
In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol
Authors: Jeong Dahye , Shin Hyosook , Lee Jinhee , Yang Junyoung , Jung Kikyung , Jeong Jayoung , Won Hansol , Oh Jaeho
Published: January 2022

Chlorobutanol (CB) is used as a preservative in cosmetics and has antibacterial activity. This study investigated the single- and repeated-dose 28-day oral toxicity of a CB solvent in Sprague Dawley (SD) rats. For the single-dose oral toxicity study, a dose of 62.5, 125, or 250 mg per kg of body weight (mg/kg b.w.) of CB was given once orally via gavage. For the repeated-dose 28-day toxicity study, the high dose was set as 100 mg/kg b.w./day, and the middle, middle-low, and low doses were set to 50, 25, and 12.5 mg/kg b.w./day, respectively. Body weight was not significantly changed in the repeated-dose toxicity study. Relative liver and kidney weights were significantly increased in both sexes of the 100 mg/kg b.w./day treatment group. However, there were histopathological changes in liver and kidney for females and males, respectively. These data suggested that the approximate lethal dose (ALD) of CB was over 250 mg/kg b.w./day in the single-dose study, and the no adverse effect level (NOAEL) for CB was over 50 and 12.5 mg/kg b.w./day for female and male rats in the repeated-dose toxicity study.
Innate Immunity Response to BK Virus Infection in Polyomavirus-Associated Nephropathy in Kidney Transplant Recipients
Authors: Chancharoenthana Wiwat , Leelahavanichkul Asada
Published: January 2022

BK polyomavirus (BKV) mainly causes infection in uroepithelial and renal tubular epithelial cells of either immunocompetent or immunocompromised hosts. Despite asymptomatic or mild clinical features in immunocompetent hosts with BK infection, serious complications are frequently found in immunocompromised patients, especially patients with kidney transplantation. Accordingly, BKV-associated nephropathy (BKVN) demonstrates a wide range of clinical manifestations, including ureteric stenosis and hemorrhagic cystitis. In addition, BKV re-infection in post-kidney transplantation is also a main cause of kidney allograft dysfunction and graft loss. Since the direct anti-BKV is unavailable, immune response against BKV infection is the main mechanism for organism control and might be a novel strategy to treat or suppress BKV. As such, the innate immunity, consisting of immune cells and soluble molecules, does not only suppress BKV but also enhances the subsequent adaptive immunity to eradicate the virus. Furthermore, the re-activation of BKV in BKVN of kidney-transplanted recipients seems to be related to the status of innate immunity. Therefore, this review aims to collate the most recent knowledge of innate immune response against BKV and the association between the innate immunity status of kidney-transplanted recipients and BKV re-activation.
COVID-19 Pandemic: Influence of Gender Identity on Stress, Anxiety, and Depression Levels in Canada
Authors: Chima Chidi , Shalaby Reham , Lawal Mobolaji A. , Vuong Wesley , Hrabok Marianne , Gusnowski April , Surood Shireen , Greenshaw Andrew J. , Wells Kristopher , Agyapong Vincent I. O.
Published: January 2022

Background: This cross-sectional study explored variation of the prevalence of perceived stress, depression and anxiety among different self-identified gender identity groups in the Canadian population during the early stages of the COVID-19 pandemic. Methods: Anxiety, depression, and stress were assessed using the Generalized Anxiety Disorder 7-item (GAD-7) scale, Patient Health Questionnaire-9 (PHQ-9), and Perceived Stress Scale (PSS) respectively. Data were analyzed using one-way analysis of variance. Results: There were 8267 respondents to the online survey; 982 (12.0%) were male-identified, 7120 (86.9%) female-identified, and 92 (1.1%) identified as a diverse gender group. Prevalence rates for clinically meaningful anxiety (333 (41.7%), 2882 (47.6%), 47 (61.0%)), depression (330 (40.2%), 2736 (44.3%), 46 (59.7%)), and stress (702 (79.6%), 5711 (86.4%), 74 (90.2%)) were highest among respondents who self-identified as “other gender” followed by female-identified and then male-identified, respectively. There were statistically significant differences between gender groups for mean scores on GAD-7 (F (2, 6929) = 18.02, p < 0.001), PHQ-9 (F (2, 191.4) = 11.17, p < 0.001), and PSS (F (2, 204.6) = 21.13, p < 0.001). Conclusions: Gender identity differences exist in terms of the prevalence and severity of anxiety, depressive, and stress symptoms during the COVID-19 pandemic. This finding highlights the importance of incorporating self-identified gender identity in medical research, clinical practice, and policy.
Editorial for the Special Issue “Relativistic Astrophysics”
Authors: De Paolis Francesco , Nucita Achille A. , Zakharov Alexander F.
Published: January 2022

Relativistic Astrophysics is the branch of astrophysics that studies astronomical phenomena and celestial bodies, for which classical mechanics and Newton’s law of gravitation are inapplicable to creation of suitable models and we have to generalize these approaches following general relativistic prescriptions [...]
Evaluation of the UMASEP-10 Version 2 Tool for Predicting All >10 MeV SEP Events of Solar Cycles 22, 23 and 24
Authors: Núñez Marlon
Published: January 2022

The prediction of solar energetic particle (SEP) events may help to improve the mitigation of adverse effects on humans and technology in space. UMASEP (University of Málaga Solar particle Event Predictor) is an empirical model scheme that predicts SEP events. This scheme is based on a dual-model approach. The first model predicts well-connected events by using an improved lag-correlation algorithm for analyzing soft X-ray (SXR) and differential proton fluxes to estimate empirically the Sun–Earth magnetic connectivity. The second model predicts poorly connected events by analyzing the evolution of differential proton fluxes. This study presents the evaluation of UMASEP-10 version 2, a tool based on the aforementioned scheme for predicting all >10 MeV SEP events, including those without associated flare. The evaluation of this tool is presented in terms of the probability of detection (POD), false alarm ratio (FAR) and average warning time (AWT). The best performance was achieved for the solar cycle 24 (i.e., 2008–2019), obtaining a POD of 91.1% (41/45), a FAR of 12.8% (6/47) and an AWT of 2 h 46 min. These results show that UMASEP-10 version 2 obtains a high POD and low FAR mainly because it is able to detect true Sun–Earth magnetic connections.
What Happens in Your Brain When You Walk Down the Street? Implications of Architectural Proportions, Biophilia, and Fractal Geometry for Urban Science
Authors: Brielmann Aenne A. , Buras Nir H. , Salingaros Nikos A. , Taylor Richard P.
Published: January 2022

This article reviews current research in visual urban perception. The temporal sequence of the first few milliseconds of visual stimulus processing sheds light on the historically ambiguous topic of aesthetic experience. Automatic fractal processing triggers initial attraction/avoidance evaluations of an environment’s salubriousness, and its potentially positive or negative impacts upon an individual. As repeated cycles of visual perception occur, the attractiveness of urban form affects the user experience much more than had been previously suspected. These perceptual mechanisms promote walkability and intuitive navigation, and so they support the urban and civic interactions for which we establish communities and cities in the first place. Therefore, the use of multiple fractals needs to reintegrate with biophilic and traditional architecture in urban design for their proven positive effects on health and well-being. Such benefits include striking reductions in observers’ stress and mental fatigue. Due to their costs to individual well-being, urban performance, environmental quality, and climatic adaptation, this paper recommends that nontraditional styles should be hereafter applied judiciously to the built environment.
To What Extent Does Frailty Influence the Risk of Developing Urolithiasis?
Authors: Wu Henry H. L. , Chinnadurai Rajkumar
Published: January 2022

Urolithiasis has become more prevalent in recent years, given the rapid rise of the global geriatric population. Although factors such as ethnicity, dietary and fluid intake, co-morbidity status and age have been associated with increased incidence of urolithiasis, the links between frailty status and risks of developing urolithiasis are not yet known. In this commentary, we will explore the scale and significance of this relationship based on emerging evidence. We will review the plausible factors on how a more severe frailty status may be significantly associated with greater risks of developing urolithiasis. We will also discuss the strategies that may help to lower the incidence of urolithiasis in older and frail individuals. We hope our article will bring greater awareness on this issue and motivate further research initiatives evaluating the relationship between frailty and urolithiasis, as well as holistic prevention strategies to lower the risks of developing urolithiasis within this vulnerable population.
Boosting Humoral Immunity from mRNA COVID-19 Vaccines in Kidney Transplant Recipients
Authors: Tylicki Leszek , Dębska-Ślizień Alicja , Muchlado Marta , Ślizień Zuzanna , Gołębiewska Justyna , Dąbrowska Małgorzata , Biedunkiewicz Bogdan
Published: January 2022

Introduction: The immune response to the primary (two-dose) series of mRNA COVID-19 vaccines in kidney transplant recipients (KTRs) is very weak. We conducted a longitudinal observational study to compare the humoral response to a third, additional primary dose of mRNA vaccines between infection-naïve (IN-KTRs) and previously infected KTRs (PI-KTRs). Methods: We measured the levels of anti-spike (anti-s) IgG antibodies before and 14–21 days after the third dose and, in the secondary analysis, we compared the antibody response to BNT162b2 versus mRNA-1273. The reactogenicity assessment included solicited local and systemic reactions. Results: A total of 112 KTRs were enrolled, including 83 IN-KTR and 29 PI-KTR, among whom seroconversion in anti-s antibodies after the primary two-dose vaccination was achieved in 45.78% and 100% of cases, respectively. After three months, a waning antibodies titer by 67.4% (IN-KTR) and 7.5% (PI-KTR) was observed. After the third dose of the mRNA vaccine, 71.08% (59/83) of IN-KTR and 96.5% (28/29) of PI-KTR samples were seroconverted with a median anti-s titer of 468.0 (195.0–1620.0) BAU/mL and 1629.0 (1205–1815) BAU/mL, respectively. Of those IN-KTR in whom the primary vaccination failed, 46.67% (21/45) of patients achieved seroconversion after the third dose. No serious adverse events after the third dose were reported. In strata analyses, after the third dose, 66% (40/60) of patients vaccinated with BNT162b2 and 82.6% (19/23) of patients vaccinated with mRNA-1273 seroconverted with a median anti-s titer of 384.5 (144–837) BAU/mL and 1620 (671–2040) BAU/mL, respectively. Conclusions: The use of a third dose of mRNA vaccine may be of benefit for KTR, especially for those in whom the primary vaccination failed. Vaccines with a higher dose of mRNA and a longer interval between doses of the primary vaccination, such as mRNA-1273, seem to be the preparations of choice in immunocompromised individuals.
After 100 Years of BCG Immunization against Tuberculosis, What Is New and Still Outstanding for This Vaccine?
Authors: Flores-Valdez Mario Alberto
Published: January 2022

In 2021, most of the world was reasonably still concerned about the COVID-19 pandemic, how cases were up and down in different countries, how the vaccination campaigns were ongoing, and most people were familiar with the speed with which vaccines against SARS-Co-V2 were developed, analyzed, and started to be applied in an attempt to curb the pandemic. Because of this, it may have somehow passed relatively inadvertently for people outside of the field that the vaccine used to control tuberculosis (TB), Mycobacterium bovis Bacille Calmette-Guérin (BCG), was first applied to humans a century ago. Over these years, BCG has been the vaccine applied to most human beings in the world, despite its known lack of efficacy to fully prevent respiratory TB. Several strategies have been employed in the last 20 years to produce a novel vaccine that would replace, or boost, immunity and protection elicited by BCG. In this work, to avoid potential redundancies with recently published reviews, I only aim to present my current thoughts about some of the latest findings and outstanding questions that I consider worth investigating to help develop a replacement or modified BCG in order to successfully fight TB, based on BCG itself.
Role of Clostridium perfringens Necrotic Enteritis B-like Toxin in Disease Pathogenesis
Authors: Lee Kyung-Woo , Lillehoj Hyun S.
Published: January 2022

Necrotic enteritis (NE) is a devastating enteric disease caused by Clostridium perfringens type A/G that impacts the global poultry industry by compromising the performance, health, and welfare of chickens. Coccidiosis is a major contributing factor to NE. Although NE pathogenesis was believed to be facilitated by α-toxin, a chromosome-encoded phospholipase C enzyme, recent studies have indicated that NE B-like (NetB) toxin, a plasmid-encoded pore-forming heptameric protein, is the primary virulence factor. Since the discovery of NetB toxin, the occurrence of NetB+ C. perfringens strains has been increasingly reported in NE-afflicted poultry flocks globally. It is generally accepted that NetB toxin is the primary virulent factor in NE pathogenesis although scientific evidence is emerging that suggests other toxins contribute to NE. Because of the complex nature of the host-pathogen interaction in NE pathogenesis, the interaction of NetB with other potential virulent factors of C. perfringens needs better characterization. This short review will summarize the primary virulence factors involved in NE pathogenesis with an emphasis on NetB toxin, and a new detection method for large-scale field screening of NetB toxin in biological samples from NE-afflicted commercial broiler flocks.
Large-Scale Study of Antibody Titer Decay following BNT162b2 mRNA Vaccine or SARS-CoV-2 Infection
Authors: Israel Ariel , Shenhar Yotam , Green Ilan , Merzon Eugene , Golan-Cohen Avivit , Schäffer Alejandro A. , Ruppin Eytan , Vinker Shlomo , Magen Eli
Published: January 2022

Immune protection following either vaccination or infection with SARS-CoV-2 is thought to decrease over time. We designed a retrospective study, conducted at Leumit Health Services in Israel, to determine the kinetics of SARS-CoV-2 IgG antibodies following administration of two doses of BNT162b2 vaccine, or SARS-CoV-2 infection in unvaccinated individuals. Antibody titers were measured between 31 January 2021, and 31 July 2021 in two mutually exclusive groups: (i) vaccinated individuals who received two doses of BNT162b2 vaccine and had no history of previous infection with COVID-19 and (ii) SARS-CoV-2 convalescents who had not received the vaccine. A total of 2653 individuals fully vaccinated by two doses of vaccine during the study period and 4361 convalescent patients were included. Higher SARS-CoV-2 IgG antibody titers were observed in vaccinated individuals (median 1581 AU/mL IQR [533.8–5644.6]) after the second vaccination than in convalescent individuals (median 355.3 AU/mL IQR [141.2–998.7]; p < 0.001). In vaccinated subjects, antibody titers decreased by up to 38% each subsequent month while in convalescents they decreased by less than 5% per month. Six months after BNT162b2 vaccination 16.1% subjects had antibody levels below the seropositivity threshold of <50 AU/mL, while only 10.8% of convalescent patients were below <50 AU/mL threshold after 9 months from SARS-CoV-2 infection. This study demonstrates individuals who received the Pfizer-BioNTech mRNA vaccine have different kinetics of antibody levels compared to patients who had been infected with the SARS-CoV-2 virus, with higher initial levels but a much faster exponential decrease in the first group.
Identification of B-Cell Epitopes of HspA from Helicobacter pylori and Detection of Epitope Antibody Profiles in Naturally Infected Persons
Authors: Zhang Xin , Sang Shuli , Guan Qing , Tao Haoxia , Wang Yanchun , Liu Chunjie
Published: January 2022

Helicobacter pylori (H. pylori), heat-shock protein A (HspA), is a bacterial heat-shock chaperone that serves as a nickel ion scavenging protein. Ni2+ is an important co-factor required for the maturation and enzymatic activity of H. pylori urease and [NiFe] hydrogenase, both of which are key virulence factors for pathogen survival and colonization. HspA is an important target molecule for the diagnosis, treatment, and immune prevention of H. pylori. In this work, HspA was truncated into five fragments to determine the location of an antigen immunodominant peptide. A series of overlapping, truncated 11-amino-acid peptides in immunodominant peptide fragments were synthesized chemically and screened by ELISA. The immunogenicity and antigenicity of the screened epitope peptides were verified by ELISA, Western blot, and lymphocyte proliferation tests. Two novel B-cell epitopes were identified, covering amino acids 2–31 of HspA, which are HP11 (2–12; KFQPLGERVLV) and HP19 (18–28; ENKTSSGIIIP). The antiserum obtained from HP11-KLH and HP19-KLH immunized mice can bind to naive HspA in H. pylori SS2000, rHspA expressed in E. coli, and the corresponding GST fusion peptide. Among HspA seropositive persons, the seropositive rates of HP11 and HP19 were 21.4% and 33.3%, respectively. Both of the B-cell epitopes of HspA are highly conserved epitopes with good antigenicity and immunogenicity.
Attitudes of Poles towards the COVID-19 Vaccine Booster Dose: An Online Survey in Poland
Authors: Babicki Mateusz , Mastalerz-Migas Agnieszka
Published: January 2022

Introduction: COVID-19 vaccination has now become the most effective way to combat the pandemic, but there is a gradual decline in the protection that it offers over time. Therefore, the Food and Drug Administration (FDA) and EMA now recommend the use of the so-called booster dose, especially in at-risk groups. The purpose of the study was to assess the attitudes of Poles towards the recommendation to receive a booster dose of the COVID-19 vaccine and to evaluate the main reasons for refusing or delaying the decision. Material and methods: The study was based on a proprietary questionnaire distributed via the Internet. There were 1598 respondents, 54 of which did not consent to participate in the survey and/or did not complete the vaccination against SARS-CoV-2. As a result, 1528 surveys were included in the final analysis. The vast majority of the respondents, namely 1275 (83.4%), were female, and 772 (50.5%) were residents of cities with a population of over 250,000. Results: Out of all respondents, 38 (2.5%) had already received the COVID-19 vaccine booster dose and 1031 (67.4%) would like to receive it as soon as possible. Forty-five (2.9%) respondents reported that they were completely unwilling to take the booster dose. The occurrence of adverse events after primary vaccination were reported by 79.9% of the survey participants. The most common reasons why the respondents refused to be vaccinated are lack of confidence in the effectiveness of the booster dose and the occurrence of adverse events in them or their loved ones. Age, gender, residence, or relationship status were not shown to affect attitudes towards the expansion of the basic vaccination schedule. Conclusions: One in three respondents plans to delay or refrain from taking the COVID-19 vaccine booster dose. The main reason for refusal to be vaccinated is the belief that the previous vaccination provides sufficient protection.
Inclusive Education for Health: Analysis of the Mandatory Nature of Vaccination and Its Regulation by Administrations, and Implications and Considerations for Vaccination against COVID
Authors: García-Toledano Eduardo , López-Parra Emilio , Cebrián-Martínez Antonio , Palomares-Ruiz Ascensión
Published: January 2022

In the process of vaccination against COVID-19, the problem of parents who do not want to vaccinate their school-age children has been evident. A conflict arises between two fundamental rights: the right to ideological freedom, privacy, and physical integrity of parents and minors who do not opt for vaccination; and the right to health of the rest of the children who attend the same school, provoking a social debate on the need to introduce regulatory changes that favor the mandatory imposition of vaccination in certain cases. This research offers an observational study through a cross-sectional design of a quantitative nature, in which one thousand people belonging to the education, health, and economy sectors from seventy-six countries of five continents have participated. The instrument used was a previously validated questionnaire: VACUNASEDUCA. It was considered essential to know the awareness of vaccination processes of professionals from essential social sectors. Therefore, the objectives were: to reflect on the measures of mandatory vaccination, to know the importance of teachers being able to demand a regulated vaccination card from students, to study the need for regulation by administrations of compliance with vaccines, and to analyze the importance of health education. It has been shown that women and those under thirty years of age are the least in favor of compulsory vaccination, with the health sector being the most defending of their demand, and with Europe with the lowest means. It is concluded that mandatory vaccination could be an acceptable tactical option to prevent high-risk situations.
Circulating Cytokines in Metastatic Breast Cancer Patients Select Different Prognostic Groups and Patients Who Might Benefit from Treatment beyond Progression
Authors: Paccagnella Matteo , Abbona Andrea , Michelotti Andrea , Geuna Elena , Ruatta Fiorella , Landucci Elisabetta , Denaro Nerina , Vanella Paola , Lo Nigro Cristiana , Galizia Danilo , Merlano Marco , Garrone Ornella
Published: January 2022

Cancer induces immune suppression to overcome its recognition and eradication by the immune system. Cytokines are messengers able to modulate immune response or suppression. There is great interest in the evaluation of their changes during treatment in order to identify their relationship with clinical outcome. We evaluated 18 cytokines in breast cancer patients treated with eribulin before starting treatment (T0) and after four courses of therapy (T1). Longitudinal modifications were considered and cytokine clusters through PCA and HCPC correlated to patients’ outcomes were identified. Forty-one metastatic breast cancer patients and fifteen healthy volunteers were included. After clustering, we identified at T0 six patient clusters with different risk of relapse and death. At T1, only four clusters were identified, and three of them accounted for thirty-eight of forty-one patients, suggesting a possible role of treatment in reducing heterogeneity. The cluster with the best survival at T1 was characterized by low levels of IL-4, IL-6, IL-8, IL-10, CCL-2, CCL-4, and TGF-β. The cluster showing the worst survival encompassed high levels of IL-4, IL-6, IL-8, IL-10, CCL-2, and IFN-γ. A subgroup of patients with short progression-free survival (PFS) and long overall survival (OS) was comprised in the cluster characterized by low levels of CCL-2, IL-6, IL-8, IL-10, and IL-12 at T0. Our data support the prognostic significance of longitudinal serum cytokine analysis. This approach may help identify patients for whom early treatment stop avoids needless toxicity or might justify treatment beyond early progression. Further investigations are required to validate this hypothesis.