bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring accuracy of Dataset using Deep Learning Algorithm RMSProp Algorithm
Authors: Gedela Sanjana Naidu
Published: October 2021

Abstract: Over the last few years, there have been many significant improvements in the field of AI, machine learning, deep learning are being used in various industries and research. In order to train the deep learning models learning of parameters plays a major role, here the reduction of loss incurred during the training process is the main objective. In a supervised mode of learning, a model is given the data samples and their respective outcomes. When a model generates an output, it compares it with the desired output and then takes the difference of generated and desired outputs and then attempts to bring the generated output close to the desired output. This is achieved through optimization algorithms. Though many kinds of clinical methods have been employed to detect whether patients have heart disease or not by number of features from patients. but it’s still a challenging task due to the multitude of data elements involved. The motive of our project is to save human resources in medical centers and improve accuracy of diagnosis. In our project we used an RMS prop optimizer. The purpose is to decide how many hidden layers need to be selected and how many neurons need to be selected in each and every hidden layer by looking at the dataset and to give the application of deep learning to the health care sector so that we can minimize the costs of treatment and help in proactive actions. We want to show that we can increase the accuracy of the project by taking stability along with accuracy into consideration. Index Terms: RMS Prop, Machine Learning, Deep Learning, number of features, proactive actions
Aries Lagna Impacts on Yoga for Foreign Visit
Authors: Rajaraman A
Published: October 2021

Abstract: The history of any art is the basic nail root. In ancient times humans were first seen as the basis of omens and then began to worship the planets as deities due to the effects of the rages of nature. They then began to observe the changes in nature caused by the planets and the consequences. As a result of such research, the planets Sun, Mars and Saturn were divided into evil planets and the planets Moon, Mercury, Guru and Venus were divided into virtuous planets. Based on this they have been doing continuous study of people for centuries. The effects of planetary influences on this planet were first seen only by nations and kings, and then gradually benefited an individual. The result was a gradual breakdown of the sky, galaxy, and zodiac. Historians believe that the oldest fortune-teller was written on April 29, 410 BC. Going abroad was considered a great achievement and an active activity in the 1970s - 80s. It was considered an act performed only by the affluent. They only went abroad for higher studies and work. Due to the subsequent scientific development and technological development, going abroad has become a very simple thing. Indians got job opportunities abroad through computer and software. The growth of India's current computer industry has made it easier for all people to go abroad. Keywords: Bhakyashtana, Bhakyathipathi, pada, Dasa, Buddhi
Investment in Agriculture and Increasing Its Efficiency
Authors: Xudoyberdiyevich Xurramov Eshmamat
Published: October 2021

Annotation: Investments are made in any socio-economic formations. Because they are spent on strengthening the state, the industry, enterprises, and, finally, the economic base of the population. It is an objective necessity to invest in the development of agriculture in the Republic of Uzbekistan, where a free market economy is gradually being formed. In this article, we will learn about investment and capital investment in agriculture and how to increase their efficiency. Keywords: investments, population, efficiency, capital investments.
Chlorine As a Disinfectant in Water Treatment
Authors: Muntaha Rifahat
Published: October 2021

Abstract: Disinfection of treated water is a necessary process. For this, chlorine and its products are widely used. During the treatment process, chlorine is added to drinking water as elemental chlorine, sodium hypochlorite solution or dry calcium hypochlorite. When applied to water, each of these forms “free chlorine”, which destroys pathogenic organisms. If adequate water treatment is not readily available, the impact on public health can be devastating. Worldwide, about 1.2 billion people lack access to safe drinking water, and about 2.4 billion people lack sanitation. As per WHO, 3.4 million people die from waterrelated diseases. Drinking water chlorination will remain a cornerstone of disinfection. This is because of the wide range of benefits provided by chlorine. However, alternative disinfectants including ozone and UV radiation are available, all disinfection methods have unique benefits, limitations and costs. So, an engineer has to consider all the pros and cons of a disinfectant method properly before deciding the one to adopt. Keywords: Disinfection, Gaseous Chlorination, Sodium Hypochlorite, Calcium Hypochlorite, Ultraviolet, Ozone, Chlorine dioxide
Evaluation and Comparative Analysis of Speed Performance of Brushless DC Motor using Digital Controllers
Authors: Wadhonakar Kunal Anant
Published: October 2021

Abstract: This paper presents modeling, performance evaluation, and comparative analysis of speed performance of brushless DC motor (BLDCM) by using digital controllers. Speed performance analysis is carried out by using time response specifications which are useful for determining the effectiveness of the digital controllers. The wide spread of BLDCM in many areas due to the advantages of BLDCM over the conventional widely used motors such as induction motor and brushed DC motor. Advantages of BLDCM include higher efficiency, lower maintenance, longer life, reduced losses, single excitation, etc. Controllers are used to improve the transient and steady state speed response of the BLDCM. In many applications conventional PID controller is widely used to control the speed of the BLDCM but the main issue with the conventional PID controller is that it requires manual tuning of the parameters such as proportional, integral, and derivative gain constant. Even though the autotuning methods are available with the PID controller it is not adaptive itself to handle the conditions such as variations in parameters, disturbances in load, etc. In this Paper the Fuzzy-PID controller is used to control the speed of the BLDCM and Transient and steady state speed performance analysis is carried out using conventional PID controller and Fuzzy-PID to showcase the comparative analysis between two controllers. MATLAB/SIMULINK environment is used for modeling of the BLDCM and its drive/control system. Keywords: Brushless DC Motor (BLDCM), Fuzzy Logic Controller (FLC), Modeling of BLDC drive/control system, of PID controller, Transient and steady state analysis
INCLUSION DE ACEITE DE LINAZA EN UN ALIMENTO COMERCIAL SUMINISTRADO A Eugerres plumieri
Authors: Cerón Benavides Sandra Milena , Gómez León Javier , Imúes Figueroa Marco Antonio , Santos Acevedo Marisol
Published: October 2021

La mojarra rayada es una de las especies de mayor importancia comercial en la Ciénaga Grande de Santa Marta –CGSM, conscientes de su importancia económica y de las problemáticas que enfrenta la especie en cuestión, se consideró determinar el efecto de suministrar un alimento comercial con inclusión del aceite de linaza en el crecimiento y composición bioquímica de Eugerres plumieri; para ello se realizó un ensayo de alimentación con tres tratamientos, en el que se evaluó el efecto del pellet comercial con previa modificación de su flotabilidad, e incorporaciones de aceite de linaza a dicho concentrado en proporciones de 5 y 10%. Se pudo determinar que no se presentaron diferencias significativas entre las medias de los tres tratamientos en cuanto a tasa de crecimiento, factor de conversión y composición bioquímica del ejemplar. Por los resultados de los experimentos, se concluye que, la especie presenta alta supervivencia (>90%), rápida adaptabilidad a cautiverio y altos niveles de lípidos (12%) y proteína (61%). Por lo tanto, se recomienda su cultivo y la necesidad de continuar con su estudio, especificando, optimas densidades de siembra, requerimientos nutricionales de la especie, el perfil de ácidos grasos en su dieta y filete acorde con cada etapa de vida.
Experiencing Loneliness by Seniors during the Covid-19 Pandemic on the Example of Poland and Slovakia
Authors: Jusko P. , Kaczmarek K. , Sivok R.
Published: October 2021

Loneliness - a subjective, emotional state of feeling social isolation and being cut off from others. It comes and goes when life situation changes. In the case of chronic loneliness, it is experienced no matter what the circumstances. Loneliness functions in the temporal (time) dimension: it can be continuous, but it can also occur temporarily. The feeling of loneliness occurs in situations where the emotional bond is broken or in the case of isolation. The aim of this article is to address the problem of seniors' loneliness which is caused by the limitations of the Covid-19 pandemic. The participants of the study are seniors living in Poland and Slovakia. Research conducted in Poland, with two elderly women over 70, living in a small fishing village in the north of the country, shows that they experience unpleasant states of loneliness despite having adequate relationships with other people. As observations show, the increase in loneliness is caused by conditions that require the observance of precautionary measures related to the pandemic and restrictions on socializing and conducting classes in senior clubs. The above factors result in shallowing interpersonal interactions; weakening interpersonal relations; contribute to more superficial contacts mainly by telephone. Seniors who are in care at the Retirement Home and Nursing Home in Slovakia also admit to feeling lonely, though not directly. From the conversation, however, it can be concluded that this condition does not result directly from pandemic limitations, but rather from too little contact with loved ones. The presence of other residents and staff, contact with people, meals, activities and conversations significantly fill the time during the day. The study was aimed at checking the facts of loneliness faced by seniors living in Slovakia and Poland as well as providing information about their views on their situation. The aim of the study is also to indicate the direction that will be helpful in combating and preventing such a pejorative phenomenon as loneliness. The research was conducted in the form of an interview. In order for the quality of the interviews to be as high as possible, the respondents were selected from various backgrounds. In Poland, there were two single women, aged over 70, living in a tiny fishing village; in Slovakia they were clients of the Retirement Home and the Nursing Home in Rimavska Sobota. The authors of the texts on the situation in Poland and Slovakia would like to add that the respondents waited with interest for contact from the authors of the publication; were happy that they could speak; that there were people who were interested in their problems. The researchers tried to comprehensively present the analysis of the obtained data, situations and statements of the respondents and, using the bricollage technique, to interpret it in detail. The most important issues raised in the interviews were additionally summarized in the conclusions.
Gender, Age, previous Myocardial Infarction, and Personality as Predictors of Anxiety in Patients after Myocardial Infarction
Authors: Libova L. , Minarik P. , Solgajova A. , Sollar T. , Zrubcova D. , Turzakova J. , Vorosova G.
Published: October 2021

Objectives: The first research objective was to study the prevalence of anxiety in patients after myocardial infarction; next objective was to investigate demographic and personality predictors of anxiety. Methods: 100 hospitalized patients after myocardial infarction were studied. The Mini IPIP tool was used for the evaluation of personality characteristics and HADS-A scale was used for the evaluation of anxiety. Multiple regression was used as an analytical framework. Results: The prevalence of significant anxiety among patients after myocardial infarction was high, almost one half of patients reported abnormal anxiety symptoms. Female gender, higher age, higher neuroticism and lower conscientiousness explain 66% of the variability of anxiety. Personality traits of extraversion, openness, agreeableness and previous myocardial infarctions do not show as significant predictors. Conclusion: The prevalence of anxiety in the group of patients after myocardial infarction is high. Knowing predictors of anxiety is important for better provision of care.
The Effect of Combined Bone Marrow Aspirate, Lipoaspirate, and Platelet Rich Plasma Injections on Pain, Function, and Perceived Change Amongst Individuals with Severe Knee Osteoarthritis
Authors: Kolber Morey , Purita Joseph , Fabio Santos Duarte Lana Jose , Salamh Paul , Hanney William
Published: October 2021

Background: Owing to a paucity of research on minimally processed orthobiologics, we sought to investi-gate the efficacy of minimally processed bone marrow aspirate (BMA) and fat graft with a leukocyte-rich, platelet-rich plasma (PRP) intra-articular injection series on pain, function, and global rating of change (GROC) among patients with severe knee osteoarthritis (OA).Methods: Thirty-one adults (23 females and 8 males, mean age 67 years) with clinical and radiographic evidence of knee OA (Kellgren–Lawrence ≥ 3) were included. During the initial visit, patients were exam-ined and administered the patient-specific functional scale (PSFS) and a numerical pain rating scale ranging from 0 to 10. Patients then underwent procedures to obtain 4–6 mL of PRP, a minimally processed 6 mL fat graft, and 10 mL of BMA. Patients returned twice over 6-week intervals for booster PRP injections. At each follow-up (F1 and F2), the GROC questionnaire and prior outcome measures were completed.
Results: Patients returned at an average of 41 days for the second PRP (F1) and 90 days from initial visit for the third PRP injection (F2). Friedman Chi Square analysis indicated statistically significant improvements in pain (best and worst) and PSFS from initial to F1 and F2 (P ≤ 0.001). Post hoc Wilcoxon signed-ranks analysis with Bonferroni correction identified improvement from initial to F1 and F2, as well as F1–F2 for pain, PSFS, and GROC (P ≤ 0.013). Effect sizes ranged from r = 0.32 to 0.51. Change, based on established minimum clinically important differences, indicated pain, GROC, and PSFS met thresholds at F2.
Conclusion: A minimally processed fat graft with BMA and a series of three PRP injections improved pain and function among individuals with severe knee OA who were previously recalcitrant to conservative care. Although results indicated significant improvement, clinically important change did not occur until F2. A one-arm design is a limitation of this study.
Propuestas pedagógicas alrededor del lenguaje en la educación superior
Authors: Gómez Uribe Juana Alejandra , Ramírez Otálvaro Olga Patricia , Jaramillo Mejía Leidy Jhuliana , Hoyos Sepúlveda Sandra Patricia , Quintero Montoya Laura Marcela , Cuéllar Agudelo Jorge Enrique , Arias Loaiza Wílfer León , Jiménez Tobón Juan Carlos , Caro Torres Norberto de Jesús , Moreno Torres Mónica , Pérez Rojas Katherin , Ortiz Quintero Dally
Published: October 2021

Propuestas pedagógicas alrededor del lenguaje en la educación superior es un libro que recoge las voces de diferentes autores, que transforman su quehacer en las aulas de clase universitarias y que, mediante esa transformación, presentan propuestas innovadoras alrededor del lenguaje y su enseñanza, en temas de currículo, escritura, lectura, virtualidad, literatura y Lenguaje de Señas Colombiana – español.
RUb 50 år. På en anden planet for længe, længe siden...
Authors: Katic Stefan
Published: October 2021

Tilbageblik på RUb 5´0 år belyst udfra klip fra artiklen "Roskilde Universitetsbiblioteks tilblivelse" af Morten Laursen Vig, overbibliotekar på RUb 1972-86.
RUb 50 år. Din guide til Den store Fusionsjungle
Authors: Katic Stefan
Published: October 2021

Alle taler om de mange fusioner, men ingen har overblikket. Derfor denne liste. Stor tak til bl.a. Hans Kristian Mikkelsen (KB), Bertil F. Dorch (SDU), Mogens Kragsig Jensen (SDU) og Claus Vesterager Pedersen (DFFU).
Jacob Lawrence: The Library (1960)
Authors: Katic Stefan
Published: October 2021

Billedet "The Library" (1960) af den afroamerikanske maler Jacob Lawrence hænger på Smithsonian American Art Museum (SAAM) i USA. Billedet er bragt i REVY med tilladelse fra SAAM og Scala Archives, Firenze.
Efeito da interferência de deslizamento na mobilidade dental
Authors: Vale José D. Freitas , Mainieri Ézio Teseo
Published: October 2021

A modified version of the Mühlemann macroperiodontometer was used to study horizontal tooth mobility in 36 human subjects with sliding interferences. lt was found an increased horizontal tooth mobility in the group of teeth which received the impact at the end of the slide in centric as compared to the control group. However, the physiologic tooth mobility limits were not exceeded. The results demonstrated a great variation in horizontal tooth mobility values for specific teeth.
Determinação da curva de retenção de conhecimentos
Authors: Louro Leopoldo Marques , Brito Jorge Honório M.
Published: October 2021

No abstract available
Vernizes selantes
Authors: Araujo Paulo Amarante
Published: October 2021

No abstract available
Sobre o “cinema violento” e seus manifestos esquecidos
Authors: Esteves Leonardo Gomes
Published: October 2021

Este artigo investiga a origem e o significado do “cinema violento”, proposto nas páginas da revista Opus international em junho de 1968. Sob o impacto do Maio de 68, o periódico faz uma espécie de dossiê sobre a violência, pensando em sua abrangência sobre diversas modalidades artísticas. No cinema, destacam-se os “Quatre manifestes pour un cinéma violent” e o engajamento do principal teórico por trás da publicação, Alain Jouffroy. Como conclusão, são apontados dois possíveis desdobramentos do “cinema violento”.
Corporate social responsibility in the time of COVID-19 pandemic: An exploratory study of developing country corporates
Authors: Gokarna Poojaa , Krishnamoorthy Bala
Published: October 2021

COVID-19 pandemic has long-lasting consequences on the health, economic and social life of a country (He & Harris, 2020). In a developing country like India, the socio-economic disruption has led to collaborative action between the central government and state government machinery together with the development sector to curb the impact caused by the virus. Academia substantiates the symbiotic relationship existing between the business and the society (McGuire, 1963; Carroll & Shabana, 2010). The corporates are contributing towards alleviating the pandemic situation through their corporate social responsibility (CSR) activities (Mahmud, Ding, & Hasan, 2021). This article provides insights into the CSR strategies adopted by corporates in India during the COVID-19 pandemic through exploratory research. The study is based on semi-structured interviews of 27 CSR managers involved in strategizing and implementation of CSR activities in their respective organizations. The results outline the commitment shown by corporates towards alleviating the consequence of the virus by multiple CSR strategies. Thus, this research furthers the understanding of CSR and forms a base for future research on COVID-19 and CSR
Trans-cuff leakage in bio-Bentall operation
Authors: Hamasaki Azumi , Morita Kozo , Ikeda Masahiro , Niinami Hiroshi
Published: October 2021

We have reported a case of trans-cuff leakage that occurred in a
composite graft of bio-Bentall operation. The leakage resolved several
months after surgery, similar to the trans-cuff leakage seen in simple
aortic valve replacement. We have proposed hypotheses on the mechanism
of trans-cuff leakage during a bio-Bentall operation and suggested ways
to prevent it from occurring.
How precision medicine changes medical epistemology: A formative case from Norway
Authors: Vogt Henrik , Hofmann Bjørn
Published: October 2021

Rationale and aims: Precision medicine (PM) raises a key question: How
can we know what works when the number of people with a health problem
becomes small or one (n=1)? We here present a formative case from
Norway. The Norwegian Board of Health Supervision was faced with a
cancer patient, who had improved after treatment with a drug in the
private health sector but was refused continued treatment in the public
health service due to lack of clinical trial evidence. The Board
overturned this decision, arguing that the drug had been unambiguously
documented to work in the individual case. We aim to provide an in-depth
analysis of this case and The Board´s decision and thereby to illustrate
and elucidate key epistemological and ethical issues and developments in
PM. Method: We provide our analysis and discussion using tools of
critical thinking and concepts from philosophy of science and medicine
such as uncertainty, evidence, forms of inference and causation. We also
examine the case in the light of the history of evidence-based medicine
(EBM). Results and discussion: The case reflects an epistemological
shift in medicine where PM puts greater emphasis on evidence that arises
in individual patients after the treatment is provided over preexisting
population-based evidence. PM may rely more heavily on abduction to
decide what works and qualitative, rather than quantitative judgments.
The case also illustrates a possible shift in the concept of causation
from regularity accounts to mechanistic and process accounts. We discuss
ethical implications of a shift from more “traditional” to
“personalized EBM”. Conclusion: A framework that is more based on
abductions and evidence arising in the individual case has problems in
creating quantifiable, reliable, and generalizable evidence, and in
promoting transparency and accountability. PM currently lacks clear
criteria for deciding what works in an individual, posing ethical
challenges.
Expression of degQ gene and its effect on lipopeptide production as well as the formation of secretory proteases in Bacillus subtilis strains
Authors: Lilge Lars , Vahidinasab Maliheh , Hoffmann Mareen , Treinen Chantal , Nesamani Chanthiya Kuppusamy , Adiek Isabel , Becker Philipp , Henkel Marius , Hausmann Rudolf
Published: October 2021

Bacillus subtilis is described as a promising production strain for
lipopeptides. In the case of B. subtilis strains JABs24 and DSM10T,
surfactin, and plipastatin are produced. Lipopeptide formation is
controlled, among others, by the DegU response regulator. The activating
phospho-transfer by the DegS sensor kinase is stimulated by the
pleiotropic regulator DegQ, resulting in enhanced DegU activation. In B.
subtilis 168, a point mutation in the degQ promoter region leads to a
reduction in gene expression. Corresponding reporter strains showed a
14-fold reduced expression. This effect on degQ expression and the
associated impact on lipopeptide formation was examined for B. subtilis
JABs24, a lipopeptide-producing derivative of strain 168, and B.
subtilis wild-type strain DSM10T, which has a native degQ expression.
Based on the stimulatory effects of the DegU regulator on secretory
protease formation, the impact of degQ expression on extracellular
protease activity was additionally investigated. To follow the impact of
degQ, a deletion mutant was constructed for DSM10T, while a natively
expressed degQ version was integrated into strain JABs24. This allowed
strain-specific quantification of the stimulatory effect of degQ
expression on plipastatin and the negative effect on surfactin
production in strains JABs24 and DSM10T. While an unaffected degQ
expression reduced surfactin production in JABs24 by about 25%, a
6-fold increase in plipastatin was observed. In contrast, degQ deletion
in DSM10T increased surfactin titer by 3-fold but decreased plipastatin
production by 5-fold. In addition, although significant differences in
extracellular protease activity were detected, no decrease in
plipastatin and surfactin produced during cultivation was observed.
Polyunsaturated fatty acids cause physiological and behavioral changes in Vibrio alginolyticus and Vibrio fischeri
Authors: Smith David S. , Houck Carina , Lee Allycia , Simmons Timothy B. , Chester Olivia N. , Esdaile Ayanna , Giles David , Symes Steven
Published: October 2021

Vibrio alginolyticus and Vibrio (Aliivibrio) fischeri are Gram-negative
bacteria found globally in marine environments. During the past decade,
studies have shown that certain Gram-negative bacteria, including Vibrio
species (cholerae, parahaemolyticus, and vulnificus) are capable of
using exogenous polyunsaturated fatty acids (PUFAs) to modify the
phospholipids of their membrane. Moreover, exposure to exogenous PUFAs
has been shown to affect certain phenotypes that are important factors
of virulence. The purpose of this study was to investigate whether V.
alginolyticus and V. fischeri are capable of responding to exogenous
PUFAs by remodeling their membrane phospholipids and/or altering
behaviors associated with virulence. Thin-layer chromatography (TLC)
analyses and ultra-performance liquid chromatography-electrospray
ionization mass spectrometry (UPLC/ESI-MS) confirmed incorporation of
all PUFAs into membrane phosphatidylglycerol and
phosphatidylethanolamine. Several growth phenotypes were identified when
individual fatty acids were supplied in minimal media and as sole carbon
sources. Interestingly, several PUFAs acids inhibited growth of V.
fischeri. Significant alterations to membrane permeability were observed
depending on fatty acid supplemented. Strikingly, arachidonic acid
(20:4) reduced membrane permeability by approximately 35% in both V.
alginolyticus and V. fischeri. Biofilm assays indicated that fatty acid
influence was dependent on media composition and temperature. All fatty
acids caused decreased swimming motility in V. alginolyticus, while only
linoleic acid (18:2) significantly increased swimming motility in V.
fischeri. In summary, exogenous fatty acids cause a variety of changes
in V. alginolyticus and V. fischeri, thus adding these bacteria to a
growing list of Gram-negatives that exhibit versatility in fatty acid
utilization and highlighting the potential for environmental PUFAs to
influence phenotypes associated with planktonic, beneficial, and
pathogenic associations.
Clinical and immunological characteristic and dynamic of the secondary diseases stage of HIV infection in children, taking into account the route of infection
Authors: Denisenko V. B. , Simovanyan E. M.
Published: October 2021

The purpose is to characterize the clinical picture, immune status and the natural history of HIV infection in the stage of secondary diseases in vertical and parenteral infected children.

Materials and methods. A clinical, laboratory, instrumental, immunological examination of 132 children in the stage of secondary diseases infected with HIV in a vertical way (90; I group) and parenteral way in infancy (42; II group) was carried. Results. The clinical picture of HIV infection in the stage of secondary diseases included various combinations of HIV-associated symptoms, opportunistic infections, tumors, which determines the symptomatology of a particular stage. The use of the Cox regression mathematical model of proportional intensities demonstrated a reduction in the duration of stage 4A (RR 5.8; 95% CI 1.4—10.5; P < 0.001), 4B (RR 3.4; 95% CI 1.8—4.3; P < 0.001) and 4V (RR 4.8; 95% CI 1.2—8.9; P < 0.001) in children of group I. Using the method of multiplying Kaplan-Meier estimates, the significant differences between the time curves from the beginning of the 4A stage (Р = 0.044), 4B (P < 0.001) and 4V (Р = 0.029) before the transition to the subsequent stage in children of groups I and II were established. The content of CD4 lymphocytes in the blood in patients of group I was higher as compared with group II at the time of debut of stages 4A (Me 37.5%, IQI 33—40% and Me 22%, IQI 18—24%; Р < 0.001), 4B (Me 25%, IQI 22—28% and Me 20%, IQI 18—22%; Р < 0.001) and 4V (Me 14%, IQI 12—18% and Me 11%, IQI 10—14%; Р = 0.047).

Conclusion. HIV infection in the stage of secondary diseases in children infected with the vertical way is characterized by more rapid progression compared with parenteral infected in infancy patients, which is associated with the immaturity of the immune system.
New coronavirus infection (COVID-19) in children: clinical, laboratory and diagnostic aspects
Authors: Nosyreva S. Yu. , Pankov A. S. , Korneev A. G.
Published: October 2021

The study of a new coronavirus infection (COVID-19) in children is relevant and of interest for practical health care.

Purpose: to identify the clinical and laboratory features of COVID-19 in the context of the six-month dynamics of the pandemic in children of the Orenburg region and to formulate recommendations for optimizing the diagnosis of this disease.

Materials and methods. A retrospective analysis of 2661 results of detecting SARS-CoV-2 RNA (including 170 children) was carried out on the basis of the microbiological laboratory of the Orenburg State Medical University. Age and sex, structure of preliminary diagnoses, main clinical manifestations, frequency of testing and dynamics of the PCR threshold cycle in September 2020 and January 2021 were assessed.

Results. The proportion of children examined in the Orenburg region from September 2020 to January 2021 increased from 4.6 ± 0.6% to 8.1 ± 0.7%. At the same time, the number of PCR + results also significantly increased from 5.0 ± 2.8% to 8.2 ± 2.6% (χ2 = 54.81; p = 0). The average age of children was 9—10 years old. The main reason for referral was pre-hospitalization screening not related to COVID-19. The proportion of PCR + results in this cohort was significantly lower in children than in adults. Among the clinically manifested forms in adults, the leading diagnosis was «pneumonia», and in children «ARVI». In childhood, a predominantly asymptomatic course of the disease was recorded. In children, unlike adults, PCR Ct values did not correlate with the severity and duration of the clinical manifestations of COVID-19.

Conclusion. Due to the low diagnostic value of symptoms in children, it is more expedient to focus on epidemiological data and data from the results of laboratory examination methods. When interpreting the results of PCR diagnostics of COVID-19 for prognostic purposes, it is important to take into account the patient's age.
Characteristics of post-vaccination immunity in students vaccinated against hepatitis B in the first year of life
Authors: Shamsheva O. V. , Kochetova E. O. , Polesko I. V. , Mayorova O. A. , Belyakova V. V. , Konev V. A.
Published: October 2021

Most researchers agree that the level of protective anti-HBs decreases with age after 3-fold immunization in the first year of life, which requires the introduction of a booster dose at least 5—7 years after the completed vaccination. It is necessary to continue monitoring those vaccinated against hepatitis B in the first year of life, including those from occupational risk groups.

Objective: to assess the frequency and level of anti-HBs 18 or more years after the completed course of vaccination against hepatitis B according to the standard scheme in the first year of life and to identify risk groups that need revaccination.

Of 116 donor students in Moscow, 18—22 years after the completed course of vaccination against hepatitis B according to the standard scheme carried out in the first year of life, in 42.3% of cases, the titer of specific antibodies was determined below the protective level (< 10 mME/ml). At the same time, the share of seronegative individuals among medical students was higher (52.8%). Of 116 donor students, in 38.8% of cases, the titer of protective antibodies was determined in low (10—100 mME/ml) and only in 13.8% — in high (100—1000 mME/ml) and in 5.2% — very high (> 1000 mME/ml) values. Markers of DNA HBV, HBsAg, and anti-HBcor were not detected in any cases. Medical students primarily need a revaccination against hepatitis B without a preliminary study of the initial titers of specific antibodies.
C. difficile-infection and microbyota in newborns: resolved and outstanding issues
Authors: Mazankova L. N. , Perlovskaya S. G. , Rubalchenko O. V.
Published: October 2021

The article presents an analytical review of the works of domestic and foreign authors on the problem of studying the peculiarities of the formation of the intestinal microbiota and risk factors for the development of microdysbiosis in newborns with the activation of opportunistic bacteria, including C. difficile. Special attention is paid to the effect of antibiotics on the state of the intestinal microbiota and the activation of toxigenic strains of C. difficile. Divergent views on the role of toxigenic strains of C. difficile in the development of infectious pathology of newborns are presented.
Clinical and epidemiological features of the course of the new coronavirus infection COVID-19 in children during periods of an increase in the incidence in Moscow in 2020-2021
Authors: Mazankova L. N. , Samitova E. R. , Osmanov I. M. , Afukov I. I. , Dracheva N. A. , Malakhov A. B. , Gutyrchik T. A. , Akimkin V. G. , Ploskireva A. A. , Taranov L. O.
Published: October 2021

Purpose: to identify the features of COVID-19 infection in children at different periods of the epidemiological rise in the incidence in the city of Moscow.

Results. The article presents the observation of 1561 children hospitalized in the State Medical Institution «Children's City Clinical Hospital named after Z. A. Bash-lyaeva DZM» with a diagnosis of a new coronavirus infection COVID-19 during the periods of epidemiological rises in morbidity («2nd and 3rd waves of COVID-19»). An increase in the number of hospitalized children during the «3rd wave of COVID-19», early admission dates from the onset of the disease, due to the lack of treatment effect in outpatient settings, the predominance of school-age children and adolescents, the predominant course of infection with the development of viral pneumonia CT2-3, less often CT3-4, a 10-fold reduction in the number of children with MIS-syndrome, an elongation of the period of viral release in patients.
Clinical case of a new coronavirus infection in a teenager with ulcerative colitis
Authors: Meskina E. R. , Tselipanova E. E. , Sokhatyuk T. A.
Published: October 2021

The relevance of monitoring the course of coronavirus infection COVID-19 in combination with comorbid pathology is obvious, since this new infection with immunopathological pathogenesis is not fully understood.

The article presents a clinical case of COVID-19 disease in a 14-year-old teenager from the Moscow region, who developed against the background of severe ulcerative ileocolitis of moderate activity. The new coronavirus infection contributed to the recurrence of ulcerative colitis, which required observation and treatment in a hospital setting.

The examination revealed: mild hypochromic posthemorrhagic anemia, signs of hypercoagulation characteristic of the course of ulcerative colitis; excluded: opportunistic infections, pneumonia, acute intestinal infections and intestinal bleeding.

The standard complex therapy of ulcerative colitis without the inclusion of immunosuppressors made it possible to avoid a more severe and complicated course of the new coronavirus infection. COVID-19 in the teenager was mild, antiviral therapy was not used.
Experimental study on heat transfer performance of variable area straight fin heat sinks with PCM
Authors: Madhaiyan Rajasekaran , Thannir Pandal , Balasubramanian Kumaragurubaran , Raman Mohan
Published: October 2021

The thermal performance of heat sinks with variable area straight fins with and without PCM is quantitatively explored in this article. The effects of diverse fin geometries (constant area straight fin, variable area straight fin, circular pin fin, hemispherical pin fin, and elliptical pin fin), varying Reynolds numbers, and fin densities on boosting electronics cooling performance were investigated. The goal of this research is to develop the best fin geometry for electronics cooling technologies. This research demonstrates that altering fin density can improve heat sink thermal performance while also reducing heat sink weight. The base temperature of the heat sink is found to be lower in variable area straight fins. In comparison to alternative configurations for heat transfer with PCM, the results show that variable area straight fin heat sinks are the most effective. The thermal resistance of the improved heat sink with variable fin density was reduced by 9%.
Simulation and experimental study on performance analysis of solar photovoltaic integrated thermoelectric cooler using MATLAB Simulink
Authors: Nadimuthu Lalith , Selvaraj Divya , Victor Kirubakaran
Published: October 2021

The present study investigates the performance of solar photovoltaic integrated thermoelectric cooler using MATLAB Simulink. The enhancement of efficiency has been achieved using an effective heat removal mechanism from the hot side heat sink. Since the hot side temperature is a crucial parameter. The intrinsic material properties like Seebeck coefficient, ?, thermal conductance, K, and electrical resistance, R, of the thermoelectric module are carefully estimated using analytical method and reported. The MATLAB Simulink Peltier module is developed based on the estimated intrinsic properties. The effect of system voltage (V) and current (A) on the thermal parameters like cooling capacity, QC, and coefficient of performance has been investigated. The simulation study is validated by conducting a series of experimental analysis. The experimental model is equipped with a 100 Wp polycrystalline solar photovoltaic module to integrate and power the 12V/5A of the 60 W thermoelectric cooler. Moreover, the results reveal that there is a significant effect of ambient and hot side temperature on the thermoelectric cooler performance. The fin-type conductive mode of heat transfer mechanism is adopted along with the convective forced air-cooling system to achieve effective heat removal from the hot side. The infrared thermographic investigation is carried out for ascertaining effective heat removal.
Side preference of dairy cows in the milking parlour and its impact on daily milk yield
Authors: Rencinova Vendula , Voslarova Eva , Vecerek Vladimir
Published: October 2021

Monitoring of the side preference of dairy cows in the milking parlour was performed in a group of 40 dairy cows (Czech spotted cattle). Twenty milking sessions were evaluated for each cow, and the composition of the monitored group of cows was kept constant. A significant side preference was found in 26 (65%) cows. The results show that in the dairy herd, a significant percentage of cows prefer one side of the milking parlour. Furthermore, in dairy cows with a significant side preference, their milk yield on the preferred and non-preferred side of milking parlour was compared and a statistically significant difference was found. When the dairy cows were milked on their preferred side of the milking parlour, higher milk yield was achieved (12.21 vs. 10.38 kg).
Possible Involvement of Adipose Tissue in Older and Obese Diabetic Patients with Coronavirus SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
Authors: Shin Jihoon , Toyoda Shinichiro , Nishitani Shigeki , Fukuhara Atsunori , Kita Shunbun , Otsuki Michio , Shimomura Iichiro
Published: October 2021

Aging, obesity and diabetes are major risk factors for the severe
progression and outcome of SARS-CoV-2 infection (COVID-19), but the
underlying mechanism is not yet fully understood. In this study, we
found that the SARS-CoV-2 spike protein physically interacts with cell
surface GRP78, which promotes the binding to and accumulation in
ACE2-expressing cells. GRP78 was highly expressed in adipose tissue and
increased in older and obese diabetic human and mouse subjects. The
overexpression of GRP78 was attributed to hyperinsulinemia in
adipocytes, which was in part mediated by the stress-responsive
transcription factor XBP-1s. Management of hyperinsulinemia by
pharmacological approaches, including metformin, SGLT2 inhibitor or
β3-adrenergic receptor agonist, decreased GRP78 gene expression in
adipose tissue. Environmental interventions, including exercise, calorie
restriction, fasting or cold exposure, reduced the gene expression of
GRP78 in adipose tissue. This study provides scientific evidence for the
role of GRP78 as a binding partner of the SARS-CoV-2 spike protein and
ACE2, which might be related to the severe progression and outcome of
COVID-19 in older and obese diabetic patients. The management of
hyperinsulinemia and the related GRP78 expression could be a potential
therapeutic or preventative target.
ANALISIS KEMAMPUAN BERPIKIR KRITIS MATEMATIS SISWA KELAS XI IPA 3 SMAN 1 LEMBAH MELINTANG
Authors: Halimah Nur , Rahmi Rahmi , Suryani Mulia
Published: October 2021

This research was motivated by the low ability of students to think mathematically critical thinking in solving problems. The research objective was to describe the students' mathematical critical thinking skills in class XI IPA 3. The research method used was descriptive method with a qualitative approach. The research subjects were students of SMAN 1 Lembah Melintang class XI IPA 3. The instruments used to collect data were written tests, interviews, and documentation. The test results were analyzed based on the aspect of mathematical critical thinking skills. The results showed that mathematical critical thinking skills with high category abilities can work on critical thinking test questions properly and correctly. Furthermore, the moderate ability is not able to do critical thinking test questions well, while the low category has not been able to do critical thinking test questions properly in accordance with the aspects of mathematical critical thinking skills.
ANALISIS MISKONSEPSI SISWA MENGGUNAKAN THREE TIER DIAGNOSTIC TEST BERBASIS OPEN ENDED QUESTION
Authors: Mawaddah Mawaddah , Heryandi Yandi
Published: October 2021

This study aims to: (1) find out the misconceptions experienced by students in the material of similarity and congruence by using three-tier diagnostic tests based on open-ended questions. (2) find out the large percentage of students' misconceptions on the similarity and congruence material using a three-tier diagnostic test based on open-ended questions. The research method used was descriptive qualitative. The data collection instruments used were clinical interviews and three-tier diagnostic tests based on open-ended questions. This study was conducted in the SMP Negeri 2 Palimanan. The research subjects were selected using purposive sampling techniques so that 33 students were selected from 330 students. The results of the analysis of the three-tier diagnostic test based on open-ended questions showed that (1) the misconceptions that occurred in the material of similarity and congruence of 2D shapes included pure misconceptions, false positives, and false negatives. (2) the percentage of misconceptions experienced in the material of similarity and congruence 2D shapes as a whole was 50.2% with a large percentage of pure misconceptions 32.4%, false-positive 15.6%, and false-negative 2.2%
PENGEMBANGAN MEDIA AUDIO VISUAL BERBASIS APLIKASI CANVA MATERI BANGUN RUANG LIMAS
Authors: Rohma Ani , Sholihah Ummu
Published: October 2021

The purpose of this study is to determine the validity, practicality, and effectiveness of audio-visual media based on the canva application for pyramids in VIII grade SMP Islam Al Azhaar Tulungagung with 27 students. The approach used in this study is R&D with ADDIE steps; Analysis, Design, Development, Implementation, and Evaluation. The data collection method used is a questionnaire and test. The results of the material expert validation were 3.40 (good criteria) and the media expert validation 3.50 (very good criteria). So that it can be categorized as a criteria. The practicality test of students with an average of 89.25 of the criteria is very practical. Based on the percentage of students’ effectiveness of 92.59% the criteria is very good. Based on the validation process, practicality, and effectiveness test of audio-visual media based on the canva application the pyramid material is valid, practical, and effective. The developed media can increase students’ learning motivation. So it can be used to support the implementation of direct or online learning for VIII grade Junior High School.
ANALISIS KESULITAN BELAJAR MATEMATIKA SISWA SMP DALAM PEMBELAJARAN DARING PADA MASA PANDEMI COVID-19
Authors: Wasiah Ulfatul
Published: October 2021

One of the many sectors affected by the Covid-19 pandemic is education. This resulted in a change in the learning system from face-to-face in class to online learning from home. Since online learning took place, students have experienced many difficulties in implementing it, especially in mathematics. Therefore, this research was conducted by the author to know the difficulties students encounter during online learning during a pandemic like this. The method applied in this research is the descriptive qualitative method. Observations involved SMP / MTs students with data collection techniques through questionnaires distributed online via WhatsApp and research subjects were 30 respondents. From the data that has been received, the results obtained are that most students like the Google Classroom application as an online-based learning medium, obstacles that are often experienced by students include limited quota, unsupportive signals, many tasks, and not understanding the material presented by the teacher. In addition, mathematics is considered difficult due to several factors: (1) using a lot of formulas, (2) not understanding the concept of the material, and (3) the limited space for interaction between students and teachers.
UNGKAPAN METAFORIS TEKS TERJEMAHAN AL-QUR’AN BAHASA SUNDA SURAT AL-BAQARAH: ANALISIS SEMANTIK KOGNITIF
Authors: Nur Zakiyah Shifa
Published: October 2021

Penelitian ini bertujuan untuk mendeskripsikan ungkapan metafora yang ada dalam Al-Qur’an terjemah bahasa Sunda dengan pembahasan dikhususkan pada jenis-jenis metafora dan skema citra yang ada dalam surat Al-Baqarah. Penelitian ini dilakukan dengan menggunakan metode deskriptif serta proses analisis menggunakan kajian semantik kognitif. Teori yang digunakan untuk menganalisis data adalah teori semantik kognitif mengenai jenis-jenis metafora menurut Lakoff dan Johnson (2013) serta teori mengenai skema citra menurut Cruse dan Croft (2004). ). Hasil dari penelitian ini ditemukan 15 data ungkapan metafora dalam terjemah Al-Qur’an berbahasa Sunda surat Al-Baqarah yang terbagi menjadi tiga jenis metafora konseptual, yaitu (1) metafora struktural, (2) metafora orientasional, dan (3) metafora ontologi. Sedangkan skema citra yang ditemukan dalam penelitian ini sebanyak 5 macam data diantaranya, 1 data skema citra identitas (identity), 1 data skema citra kekuatan (force), 1 data skema citra wadah (container), 3 data skema citra eksistensi (excistence) dan 3 data skema citra kesatuan (unity).
Kata Kunci: metafora, semantic kognitif, Al-Qur’an, Al-Baqarah, Sunda