bluuebunny/crossref_metadata_2025 huggingface dataset:
Bordetella pertussis-infected innate immune cells drive the anti-pertussis response of human airway epithelium
Authors: Kroes M. M. , Miranda-Bedate A. , Jacobi R. H. J. , van Woudenbergh E. , den Hartog G. , van Putten J. P. M. , de Wit J. , Pinelli E.
Published: March 2022

Pertussis is a severe respiratory tract infection caused by Bordetella pertussis. This bacterium infects the ciliated epithelium of the human airways. We investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium (HAE) differentiated at air–liquid interface. Infection of the HAE cells mimicked several hallmarks of B. pertussis infection such as reduced epithelial barrier integrity and abrogation of mucociliary transport. Our data suggests mild immunological activation of HAE by B. pertussis indicated by secretion of IL-6 and CXCL8 and the enrichment of genes involved in bacterial recognition and innate immune processes. We identified IL-1β and IFNγ, present in conditioned media derived from B. pertussis-infected macrophage and NK cells, as essential immunological factors for inducing robust chemokine secretion by HAE in response to B. pertussis. In transwell migration assays, the chemokine-containing supernatants derived from this HAE induced monocyte migration. Our data suggests that the airway epithelium on its own has a limited immunological response to B. pertussis and that for a broad immune response communication with local innate immune cells is necessary. This highlights the importance of intercellular communication in the defense against B. pertussis infection and may assist in the rational design of improved pertussis vaccines.
Natural history of retinal degeneration in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses
Authors: Murray S. J. , Mitchell N. L.
Published: March 2022

Neuronal ceroid lipofuscinoses (NCL; Batten disease) are a group of inherited neurodegenerative diseases with a common set of symptoms including cognitive and motor decline and vision loss. Naturally occurring sheep models of CLN5 and CLN6 disease display the key clinical features of NCL, including a progressive loss of vision. We assessed retinal histology, astrogliosis, and lysosomal storage accumulation in CLN5 affected (CLN5−/−) and CLN6 affected (CLN6−/−) sheep eyes and age-matched controls at 3, 6, 12, and 18 months of age to determine the onset and progression of retinal pathology in NCL sheep. The retina of CLN5−/− sheep shows progressive atrophy of the outer retinal layers, widespread gliosis, and accumulation of lysosomal storage in retinal ganglion cells late in disease. In contrast, CLN6−/− retina shows significant atrophy of all retinal layers, progressive gliosis, and earlier accumulation of lysosomal storage. This study has highlighted the differential vulnerability of retinal layers and the time course of retinal atrophy in two distinct models of NCL disease. This data will be valuable in determining potential targets for ocular therapies and the optimal timing of these therapies for protection from retinal dysfunction and degeneration in NCL.
Sunlight, dietary habits, genetic polymorphisms and vitamin D deficiency in urban and rural infants of Bangladesh
Authors: Das Subhasish , Hasan Md. Mehedi , Mohsin Minhazul , Jeorge Didarul Haque , Rasul Md. Golam , Khan Ar-Rafi , Gazi Md Amran , Ahmed Tahmeed
Published: March 2022

We conducted an observational study to assess the prevalence and risk factors of vitamin D deficiency in 12–24 months old children living in urban and rural Bangladesh. Serum 25-hydroxyvitamin D (free 25(OH)D) level, socio-demographic status, anthropometric status, dietary intake, exposure to sunlight and single nucleotide polymorphisms in vitamin-D pathway genes were measured in 208 children. Vitamin D deficiency (free 25(OH)D < 50 nmol/l) was reported in 47% of the children. Multivariable logistic regression model identified duration to sunlight exposure (regression coefficient, β =  − 0.01; 95% CI 0.00, − 0.02; p-value < 0.05), UV index (β =  − 0.36; 95% CI 0.00, − 0.02; p-value < 0.05) and breast-feeding (β =  − 1.15; 95% CI − 0.43, − 1.86; p-value < 0.05) to be negatively associated with vitamin D deficiency. We measured the role of single nucleotide polymorphisms in pathway genes (GC-rs7041 T > G, rs4588 C > A, CYP2R1-rs206793 A > G, CYP27B1-rs10877012 A > C and DHCR7-rs12785878 G > T) and found statistically significant differences in serum vitamin D levels between various genotypes. SNPs for CYP27B1 (CA & CC genotype) had statistically significant positive association (β = 1.61; 95% CI 2.79, 0.42; p-value < 0.05) and TT genotype of GC-rs7041 had negative association (β =  − 1.33; 95% CI − 0.02, − 2.64; p-value < 0.05) with vitamin-D deficiency in the surveyed children.
Prevalence and risk of Plasmodium vivax infection among Duffy-negative individuals: a systematic review and meta-analysis
Authors: Wilairatana Polrat , Masangkay Frederick Ramirez , Kotepui Kwuntida Uthaisar , De Jesus Milanez Giovanni , Kotepui Manas
Published: March 2022

A better understanding of the occurrence and risk of Plasmodium vivax infection among Duffy-negative individuals is required to guide further research on these infections across Africa. To address this, we used a meta-analysis approach to investigate the prevalence of P. vivax infection among Duffy-negative individuals and assessed the risk of infection in these individuals when compared with Duffy-positive individuals. This study was registered with The International Prospective Register of Systematic Reviews website (ID: CRD42021240202) and followed Preferred Reporting Items for Systematic review and Meta-Analyses guidelines. Literature searches were conducted using medical subject headings to retrieve relevant studies in Medline, Web of Science, and Scopus, from February 22, 2021 to January 31, 2022. Selected studies were methodologically evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Tools to assess the quality of cross-sectional, case–control, and cohort studies. The pooled prevalence of P. vivax infection among Duffy-negative individuals and the odds ratio (OR) of infection among these individuals when compared with Duffy-positive individuals was estimated using a random-effects model. Results from individual studies were represented in forest plots. Heterogeneity among studies was assessed using Cochrane Q and I2 statistics. We also performed subgroup analysis of patient demographics and other relevant variables. Publication bias among studies was assessed using funnel plot asymmetry and the Egger’s test. Of 1593 retrieved articles, 27 met eligibility criteria and were included for analysis. Of these, 24 (88.9%) reported P. vivax infection among Duffy-negative individuals in Africa, including Cameroon, Ethiopia, Sudan, Botswana, Nigeria, Madagascar, Angola, Benin, Kenya, Mali, Mauritania, Democratic Republic of the Congo, and Senegal; while three reported occurrences in South America (Brazil) and Asia (Iran). Among studies, 11 reported that all P. vivax infection cases occurred in Duffy-negative individuals (100%). Also, a meta-analysis on 14 studies showed that the pooled prevalence of P. vivax infection among Duffy-negative individuals was 25% (95% confidence interval (CI) − 3%–53%, I2 = 99.96%). A meta-analysis of 11 studies demonstrated a decreased odds of P. vivax infection among Duffy-negative individuals (p = 0.009, pooled OR 0.46, 95% CI 0.26–0.82, I2 = 80.8%). We confirmed that P. vivax infected Duffy-negative individuals over a wide prevalence range from 0 to 100% depending on geographical area. Future investigations on P. vivax infection in these individuals must determine if Duffy-negativity remains a protective factor for P. vivax infection.
Longitudinal relationships between disability and gait characteristics in people with MS
Authors: Dreyer-Alster Sapir , Menascu Shay , Dolev Mark , Givon Uri , Magalashvili David , Achiron Anat , Kalron Alon
Published: March 2022

Longitudinal data are vital in order to understand intra individual gait changes with the progression of multiple sclerosis (MS). Therefore, the primary aim of this study was to explore the relationship between changes in disability with changes in major spatio-temporal parameters of gait in people with MS (PwMS). PwMS (n = 83) completed two gait assessments performed at separate time points (M1, M2). For each individual, the absolute difference between the Expanded Disability Status Scale (EDSS) score, key spatio-temporal parameters of gait, Falls Efficacy Scale International (FES-I), and the 12-item Multiple Sclerosis Walking Scale (MSWS-12), were calculated. The mean time difference between M1 and M2 was 2.5 (SD = 1.7) years. At M2, PwMS presented with shorter strides, a wider base of support, increased perceived mobility difficulties and fear of falling compared with M1. According to the odds ratio (OR) analysis, the odds of experiencing an increase in the EDSS score was significantly higher once the MSWS-12 score increased at M2 compared with M1 (OR = 7.930, p = 0.004). This observation was highlighted specifically in people with mild-moderate MS (OR = 12.427, p < 0.001). The increase in the EDSS score was not associated with changes in key spatio-temporal parameters of gait. The present study provides a better understanding of gait and disease progression in PwMS, highlighting the significant role of the MSWS-12.
Anti-nuclear antibody and a granuloma could be biomarkers for iCIs-related hepatitis by anti-PD-1 treatment
Authors: Kondo Yasuteru , Akahira Junichi , Morosawa Tatsuki , Toi Yukihiro , Endo Akashi , Satio Hiroaki , Endo Mareyuki , Sugawara Shunichi , Tanaka Yasuhito
Published: March 2022

It has been reported that various kinds of immune checkpoint inhibitors (iCIs) could induce immune-related liver damage. We should focus on the programmed cell death-receptor-1 (PD-1) antibody and non-small cell lung cancer (NSCLC) to analyze the characteristics of hepatitis related to iCIs and find factors that could be useful biomarkers for the diagnosis. A single-center retrospective study of 252 NSCLC patients who received PD-1 antibody (nivolumab or pembrolizumab). Some of the biochemical markers and immunological markers were analyzed during PD-1-antibody treatment with or without ALT elevation. Histopathological features were reviewed by a single expert of hepatic pathology focusing on the following features: fibrosis, portal inflammation, lobular inflammation, lobular necrosis. The formation of macro- and micro-granulomas was also evaluated. The frequency of liver damage induced by nivolumab including grade 1 to 4 (ALT) was 41.9% (78/186 patients). The positive rate of anti-nuclear antibody in the nivolumab group with iCIs-related hepatitis was significantly higher than that in the nivolumab group without iCIs-related hepatitis (p = 0.00112). Granulomatous changes were significantly increased in patients with iCIs-related hepatitis compared with DILI and AIH patients (p < 0.05). The ratios of inflammatory cells CD4/CD8, and CD138/CD3 in ICIs-related hepatitis were significantly lower than those in AIH or DILI patients (p < 0.05). We demonstrated that the pre-existing ANA and characteristic liver histology including CD8+ cells dominancy and granulomatous hepatitis could be biomarkers for the diagnosis of iCIs-related hepatitis in the NSCLC with anti-PD-1 therapy.
Trends in colon and rectal cancer mortality in Australia from 1972 to 2015 and associated projections to 2040
Authors: Luo Qingwei , Lew Jie-Bin , Steinberg Julia , Worthington Joachim , Yu Xue Qin , Caruana Michael , Soerjomataram Isabelle , Bray Freddie , Lawrance Sheena , Arcorace Maria , O’Connell Dianne L. , Canfell Karen , Feletto Eleonora
Published: March 2022

Previously published sub-site Australian projections for colon and rectal cancers to 2035 using the World Health Organization’s mortality database sourced from the Australian Bureau of Statistics (ABS) predicted mortality rate decreases for colon cancer and increases for rectal cancer. There are complexities related to the interpretation of ABS’s Australian colon and rectal cancer mortality rates, which could lead to possible inaccuracies in mortality rates for these sub-sites. The largest Australian population-wide registry, New South Wales Cancer Registry (NSWCR), compares routinely-reported causes of death with the recorded medical history from multiple data sources. Therefore, this study used the NSWCR data to project mortality rates for colon and rectal cancers separately to 2040 in Australia. The mortality rates for colon cancer are projected to continuously decline over the period 2015–2040, from 7.0 to 4.7 per 100,000 males, and from 5.3 to 3.2 per 100,000 females. Similar decreasing trends in mortality rates for rectal cancer were projected over the period 2015–2040, from 4.9 to 3.7 per 100,000 males, and from 2.6 to 2.3 per 100,000 females. These projections provide benchmark estimates for the colorectal cancer burden in Australia against which the effectiveness of cancer control interventions can be measured.
Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cells
Authors: Lee Seung Hoon , Choi Mi-Ra , Chung Jaein , Choi Seung-Hyeon , Park Soo Kyoung , Kim Yong Min
Published: March 2022

Povidone-iodine (PVP-I) is an antiseptic and a disinfectant with broad-spectrum antimicrobial activity against various pathogens. However, it is unclear whether PVP-I nasal instillation can suppress mucosal inflammation in non-eosinophilic chronic rhinosinusitis (CRS) mice. This study aimed to explore the anti-inflammatory effects and underlying molecular mechanism of PVP-I on lipopolysaccharide-stimulated airway epithelial cells and investigate whether nasal instillation of PVP-I can suppress mucosal inflammation in non-eosinophilic CRS mice. Inflammation-related molecules in the nasal epithelial cells and non-eosinophilic CRS mice were measured by enzyme-linked immunosorbent assay, western blotting, quantitative real-time polymerase chain reaction, immunoprecipitation, and histopathological analysis. PVP-I blocked expressions of various inflammation-related molecules, such as NLRP3, NF-κB-p65, caspase-1, and IL-1β. Translocation of NF-κB to the nucleus, and assembly of NLRP3/ASC complexes in the nasal epithelial cells and non-eosinophilic CRS mice were also restricted. Notably, PVP-I strongly blocked the receptor co-localization of TLR4 and MyD88 in the epithelial cells of nasal mucosa. We demonstrated that PVP-I significantly attenuated inflammatory molecules and cytokines via blocking the formation of TLR4 and MyD88 complexes during LPS-induced mucosal inflammation in non-eosinophilic CRS.
Factors associated with posttraumatic growth among North Korean defectors in South Korea
Authors: Lee Mi Kyung , Kim Ocksim , Kim Kyoung-A. , Chu Sang Hui
Published: March 2022

Refugees experience various kinds of trauma during the migration process, which can cause psychiatric problems such as posttraumatic stress disorder. However, in the process of overcoming traumatic experiences, they may also experience posttraumatic growth (PTG). This study examined the level of PTG and its associated factors among North Korean defectors, including posttraumatic stress symptoms (PTSS). In total, 212 North Korean defectors completed self-report questionnaires measuring PTG (PTG inventory), PTSS (Posttraumatic Stress Disorder Checklist, PCL-5), quality of life (WHOQOL-BREF), and various sociodemographic variables. Participants completed the survey online, from July 27 to August 4, 2020. Participants reported a moderate level of PTG scores (51.7 ± 15.4, range 0–80). To determine the impact of PTSS on PTG among North Korean defectors, we conducted a hierarchical multiple regression analysis. In the final model, several sociodemographic factors (years in South Korea, education in North Korea, religion, and employment status), overall quality of life (β = 0.321,p < 0.001), and PTSS (β = 0.162,p = 0.035) were positively associated with PTG, whereas living with family (β = − 0.1261,p = 0.040) and loneliness (β = − 0.401,p < 0.001) were negatively associated with PTG, accounting for 36.6% of the variance in PTG scores (p < 0.001). This is the first large-scale study describing the level of PTG and its associated factors among North Korean defectors residing in South Korea. Further, our study provides suggestions for future research in this area, and interventions for improving PTG among this group.
Motion characteristics of subclinical tremors in Parkinson’s disease and normal subjects
Authors: Chan Ping Yi , Ripin Zaidi Mohd , Halim Sanihah Abdul , Arifin Wan Nor , Yahya Ahmad Shukri , Eow Gaik Bee , Tan Kenny , Hor Jyh Yung , Wong Chee Keong
Published: March 2022

The characteristics of the Parkinson’s disease tremor reported previously are not applicable to the full spectrum of severity. The characteristics of high- and low-amplitude tremors differ in signal regularity and frequency dispersion, a phenomenon that indicates characterisation should be studied separately based on the severity. The subclinical tremor of Parkinson’s disease is close to physiological tremor in terms of amplitude and frequency, and their distinctive features are still undetermined. We aimed to determine joint motion characteristics that are unique to subclinical Parkinson’s disease tremors. The tremors were characterised by four hand–arm motions based on displacement and peak frequencies. The rest and postural tremors of 63 patients with Parkinson’s disease and 62 normal subjects were measured with inertial sensors. The baseline was established from normal tremors, and the joint motions were compared within and between the two subject groups. Displacement analysis showed that pronation–supination and wrist abduction–adduction are the most and least predominant tremor motions for both Parkinson’s disease and normal tremors, respectively. However, the subclinical Parkinson’s disease tremor has significant greater amplitude and peak frequency in specific predominant motions compared with the normal tremor. The flexion–extension of normal postural tremor increases in frequency from the proximal to distal segment, a phenomenon that is explainable by mechanical oscillation. This characteristic is also observed in patients with Parkinson’s disease but with amplification in wrist and elbow joints. The contributed distinctive characteristics of subclinical tremors provide clues on the physiological manifestation that is a result of the neuromuscular mechanism of Parkinson’s disease.
Evaluation of cooperative and non-cooperative game theoretic approaches for water allocation of transboundary rivers
Authors: Mirzaei-Nodoushan Fahimeh , Bozorg-Haddad Omid , Loáiciga Hugo A.
Published: March 2022

Efficient water allocation in a transboundary river basin is a complex issue in water resources management. This work develops a framework for the allocation of transboundary river water between the countries located in the river basin to evaluate the characteristics of allocation approaches. The allocation of river water is obtained based on initial-water conditions, cooperative, and non-cooperative game-theoretic approaches. The initial-conditions water allocation approach assigns 34, 40, and 26% of the Harirud River flow to Afghanistan, Iran, and Turkmenistan, respectively. The game-theoretic cooperative approach assigns 36, 42, and 22% of the river flow to Afghanistan, Iran, and Turkmenistan, respectively. The non-cooperative game-theoretic approach establishes that the most stable water allocation was 42, 38, and 20% of the Harirud River flow for Afghanistan, Iran, and Turkmenistan, respectively. Human and agricultural water-stress criteria are used to evaluate the water allocations in the Harirud River basin. The criterion of human water stress has the largest influence in Iran, and the criterion of agricultural water stress has the smallest influence in Afghanistan. This work’s results indicate the initial-conditions water allocation approach favors Turkmenistan, whereas the cooperative and the non-cooperative game-theoretic approaches favors Iran and Afghanistan, respectively. The results show that the priorities of each country governs water allocation, and cooperation is shown to be necessary to achieve sustainable development.
Extremely low frequency wave localization via elastic foundation induced metamaterial with a spiral cavity
Authors: Bae Myung Hwan , Choi Wonjae , Ha Jong Moon , Kim Miso , Seung Hong Min
Published: March 2022

We proposed a metamaterial which exhibits elastic wave localization at extremely low frequencies. First, we opened an extremely low bandgap via elastic foundations. Subsequently, we investigated wave localization by imposing normal defect, which is widely used to capture waves in conventional wave localization systems. However, there were limitations: wave localization was not achieved when a weak bandgap is generated, and the operating frequency of localization is still in the upper part of the bandgap. To overcome wave localization via the normal defect, we proposed a novel metamaterial with a spiral cavity which can tune the resonating frequency depending on the length of the spiral path. By imposing on the spiral cavity inside the elastic foundation-induced metamaterial, we can shift the resonating frequency of the cavity down. Finally, we carried out wave simulations, not only to support the previous eigenfrequency study for the supercell, but also to verify that the finite-size metamaterial can also achieve wave localization at the extremely low frequencies. Through wave simulations, we could observe wave localization even at 77.3 Hz, which is definitely the lower part of the extremely low bandgap.
Determining the anatomical site in knee radiographs using deep learning
Authors: Quinsten Anton S. , Umutlu Lale , Forsting Michael , Nassenstein Kai , Demircioğlu Aydin
Published: March 2022

An important quality criterion for radiographs is the correct anatomical side marking. A deep neural network is evaluated to predict the correct anatomical side in radiographs of the knee acquired in anterior–posterior direction. In this retrospective study, a ResNet-34 network was trained on 2892 radiographs from 2540 patients to predict the anatomical side of knees in radiographs. The network was evaluated in an internal validation cohort of 932 radiographs of 816 patients and in an external validation cohort of 490 radiographs from 462 patients. The network showed an accuracy of 99.8% and 99.9% on the internal and external validation cohort, respectively, which is comparable to the accuracy of radiographers. Anatomical side in radiographs of the knee in anterior–posterior direction can be deduced from radiographs with high accuracy using deep learning.
Hemodynamic force analysis is not ready for clinical trials on HFpEF
Authors: Arvidsson Per M. , Nelsson Anders , Magnusson Martin , Smith J. Gustav , Carlsson Marcus , Arheden Håkan
Published: March 2022

Hemodynamic force analysis has been proposed as a novel tool for early detection of subclinical systolic dysfunction in heart failure with preserved ejection fraction (HFpEF). Here we investigated the ability of hemodynamic forces to discriminate between healthy subjects and heart failure patients with varying degrees of systolic dysfunction. We studied 34 controls, 16 HFpEF patients, and 25 heart failure patients with mid-range (HFmrEF) or reduced ejection fraction (HFrEF) using cardiac magnetic resonance with acquisition of cine images and 4D flow at 1.5 T. The Navier–Stokes equation was used to compute global left ventricular hemodynamic forces over the entire cardiac cycle. Forces were analyzed for systole, diastole, and the entire heartbeat, with and without normalization to left ventricular volume. Volume-normalized hemodynamic forces demonstrated significant positive correlation with EF (r2 = 0.47, p < 0.0001) and were found significantly lower in heart failure with reduced ejection fraction compared to controls (p < 0.0001 for systole and diastole). No difference was seen between controls and HFpEF (p > 0.34). Non-normalized forces displayed no differences between controls and HFpEF (p > 0.24 for all analyses) and did not correlate with EF (p = 0.36). Left ventricular hemodynamic force analysis, whether indexed to LV volumes or not, is not ready for clinical trials on HFpEF assessment.
A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis
Authors: Ge Ting , Weiwei Zhang , Ge Fei , Zhu Longbao , Song Ping , Li Wanzheng , Gui Lin , Dong Wan , Tao Yugui , Yang Kai
Published: March 2022

Synthesis of 5-Fu/ICG@ZIF-90-PEG-ZOL. Design based on bone-targeted modification on the surface of nanocarrier with ZOL, and also in combination chemotherapy and photothermal therapy (created in BioRender.com).
Serendipitous formation of oxygen-bridged CuII6M (M = MnII, CoII) double cubanes showing electrocatalytic water oxidation
Authors: San Esteban Anna Carissa M. , Kuwamura Naoto , Yoshinari Nobuto , Konno Takumi
Published: March 2022

Heterometallic CuII6MnII and CuII6CoII double-cubane clusters supported by d-penicillaminedisulfide were newly synthesized and structurally characterized, and their heterogeneous electrocatalytic activities for water oxidation were investigated.
Study on liquid-like SiGe cluster growth during co-condensation from supersaturated vapor mixtures by molecular dynamics simulation
Authors: Wang Wen-Bo , Ohta Ryoshi , Kambara Makoto
Published: March 2022

Illustrations of the formation for the different shaped clusters with cooling.
First-principles calculations of the BeO monolayer with chemical functionalization
Authors: Liu Hanlu , Feng Kehan , Lu Haiming , Meng Xiangkang
Published: March 2022

Hydrogenation and fluorination induced different magnetic and electronic properties.
Photothermal conversion performance and acid-induced aggregation of PLNP-Bi2S3 composite nanoplatforms
Authors: Meng Yangqi , Wang Mingwei , Zhu Yaqi , Wang Shuai , Yang Jian , Zhu Hancheng , Yan Duanting , Liu Chunguang , Xu Changshan , Liu Yuxue
Published: March 2022

Integrated autofluorescence-free bioimaging, temperature sensing and PTT realized using PSS modified PLNP-Bi2S3 composite nanoplatforms with photothermal conversion and pH-responsive acid-induced aggregation performances.
Effect of willow herb (Epilobium angustifolium L.) extract addition to canned meat with reduced amount of nitrite on the antioxidant and other activities of peptides
Authors: Ferysiuk Karolina , Wójciak Karolina Maria , Kęska Paulina
Published: March 2022

Investigation of the effect of the addition of various amounts of E. angustifolium extracts on the biological activity of peptides in canned meat with reduced amount of sodium nitrite and their stability during 180 days of storage (4 °C).
Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment
Authors: Xu Jinzhao , Tang Mengqi , Wu Xinyu , Kong Xiangli , Liu Yini , Xu Xiaoxi
Published: March 2022

Lactobacillus rhamnosus zz-1 can alleviate stress-induced depression-like behavior and physiological abnormalities, which is related to its regulation of the intestinal microecology (including the intestinal function and microbiota).
Development of ruthenium polypyridine metallo-monomers and characterization of their metallopolymers obtained by ROMP
Authors: Alves Elizabeth A. , Tomazett Vinicius K. , Martins Daniele M. , Lima-Neto Benedito S.
Published: March 2022

New monomeric ligands inserted in ruthenium polypyridine complexes generated metallomonomers that were copolymerized with NBE by ROMP resulting in metallopolymers.
New mechanism for autoxidation of polyolefins: kinetic Monte Carlo modelling of the role of short-chain branches, molecular oxygen and unsaturated moieties
Authors: De Keer Lies , Van Steenberge Paul , Reyniers Marie-Françoise , Gryn'ova Ganna , Aitken Heather M. , Coote Michelle L.
Published: March 2022

Using quantum-chemical calculations and kinetic modelling, we reveal the dominant reaction pathway in polymer autoxidation, (i) whether oxygen promotes or hamper degradation and (ii) how defects in the polymer backbone affect degradation.
Role of nanoparticle size and surface chemistry on ion transport and nanostructure of perfluorosulfonic acid ionomer nanocomposites
Authors: Domhoff Allison , Wang Xueting , Silva Mayura S. , Creager Stephen , Martin Tyler B. , Davis Eric M.
Published: March 2022

Both nanoparticle size and surface chemistry impact the nanostructure, as well as the water and ion transport properties of perfluorosulfonic acid ionomer nanocomposites.
Curvature effects in charge-regulated lipid bilayers
Authors: Khunpetch Petch , Majee Arghya , Podgornik Rudolf
Published: March 2022

We formulate a theory of electrostatic interactions in lipid bilayer membranes where both monolayer leaflets contain dissociable moieties that are subject to charge regulation.
Effect of stoichiometry on crosslinked epoxy resin characteristics: structural heterogeneities, topological defects, properties, free volume and segmental mobility
Authors: Sridhar Arun Srikanth
Published: March 2022

Perturbations in stoichiometry invariably induce topological defects in epoxy–amine systems which consequently affect properties. The present work elucidates the role played by topological defects on variations in properties with stoichiometry.
Mesolytic cleavage of homobenzylic ethers for programmable end-of-life function in redoxmers
Authors: Qian Hai , Counihan Michael J. , Doan Hieu A. , Ibrahim Nafisa A. , Danis Andrew S. , Setwipatanachai Worapol , Purwanto Nathan S. , Rodríguez-López Joaquín , Assary Rajeev S. , Moore Jeffrey S.
Published: March 2022

Homobenzylic ethers are screened and then incorporated into redoxmers for programmable deconstruction of energy storage materials.
Quantum of selectivity testing: detection of isomers and close homologs using an AZO based e-nose without a prior training
Authors: Goikhman Boris V. , Fedorov Fedor S. , Simonenko Nikolay P. , Simonenko Tatiana L. , Fisenko Nikita A. , Dubinina Tatiana S. , Ovchinnikov George , Lantsberg Anna V. , Lipatov Alexey , Simonenko Elizaveta P. , Nasibulin Albert G.
Published: March 2022

Gas analytical system made with AZO nanoflakes synthesized by programmed co-precipitation method exibits a remarkable chemiresistive response to alcohol homologs and isomers those selective determination is demonstrated even without a prior training.
One-step synthesis of quaternized silica nanoparticles with bacterial adhesion and aggregation properties for effective antibacterial and antibiofilm treatments
Authors: Yang Jing , Zhu Ya-Xuan , Lu Pengpeng , Zhu Baofeng , Wu Fu-Gen
Published: March 2022

Quaternized silica nanoparticles with excellent bacterial adhesion and aggregation properties are prepared for effective antibacterial and antibiofilm treatments.
Ultrasensitive determination of 39 parent and emerging halogenated polycyclic aromatic hydrocarbons in human serum
Authors: Zhao Chuxuan , Li Chengxin , Wang Chu , Li Yingming , Yang Ruiqiang , Zhang Qinghua , Jiang Guibin
Published: March 2022

Analytical methodologies were developed for emerging HPAHs in human serum to assess their exposure levels in humans and risks.
3-D printed injection system for capillary electrophoresis
Authors: Huge Bonnie Jaskowski , Young Kevin , Kerr Caitlin , Champion Matthew M. , Dovichi Norman J.
Published: March 2022

A robust and compact injection system for capillary electrophoresis that can be rapidly manufactured using 3-D printing technology.
Electroconductive and injectable hydrogels based on gelatin and PEDOT:PSS for a minimally invasive approach in nervous tissue regeneration
Authors: Furlani Franco , Montanari Margherita , Sangiorgi Nicola , Saracino Emanuela , Campodoni Elisabetta , Sanson Alessandra , Benfenati Valentina , Tampieri Anna , Panseri Silvia , Sandri Monica
Published: March 2022

This work describes the development of injectable and electroconductive hydrogels based on a biocompatible conductive polymer (PEDOT:PSS) and a biomimetic polymer (gelatin) for neural tissue regeneration.
Exosomes for diabetes syndrome: ongoing applications and perspective
Authors: Zhu Manning , Wu Jiahe , Gao Jianqing
Published: March 2022

This review provides a comprehensive overview of the state-of-the-art progress on strategies that utilize exosomes, especially engineered exosomes, for the treatment of diabetes and its complications.
Cesium carbonate mediated C–H functionalization of perhalogenated 12-vertex carborane anions
Authors: Lovera Sergio O. , Bagsdasarian Alex L. , Guo Juchen , Nelson Hosea M. , Lavallo Vincent
Published: March 2022

C–H functionalization of undecahalogenated carborane anions, [HCB11X11−] (X = Cl, Br, I), is performed with Cs2CO3 in acetonitrile.
Strategy toward fluorinated polyhedral oligomeric silsesquioxane wrapping nanoparticles for superomniphobic surfaces
Authors: Chen Boxu , Yang Mingjin , Lin Xilin , Liu Wenfeng , Yuan Hai , Liao Jingwen
Published: March 2022

In the developed strategy, the designed poc-F13POSS-2OH wraps nanoparticles upon its –OH protonation to form surfaces with broad-spectrum superomniphobicity.
Vibrationally resolved photoelectron angular distributions of ammonia
Authors: González-Collado Celso M. , Plésiat Etienne , Decleva Piero , Palacios Alicia , Martín Fernando
Published: March 2022

Photoelectron angular distributions of ammonia reflect, under special circumstances, the double-well potential of its umbrella mode.
Molybdenum carbide anchored on glucose-derived carbon (β-Mo2C@C) as a bifunctional catalyst for conversion of fructose to 2,5-diformylfuran
Authors: Yang Zhenzhen , He Yuhan , Tang Pengfei , Zhu Bangchong , Zhang Genlei , He Jianbo
Published: March 2022

Molybdenum carbide anchored on glucose-derived carbon (β-Mo2C@C) has been successfully synthesized and applied as a bifunctional catalyst for one-pot conversion of fructose to DFF.
HgBrI: a possible tecton for NLO molecular materials?
Authors: Giordana Alessia , Priola Emanuele , Pantaleone Stefano , Andreo Luca , Mortati Leonardo , Benzi Paola , Operti Lorenza , Diana Eliano
Published: March 2022

Mixed mercury(ii) halogenides are interesting NLO materials: the complexes of HgBrI obtained in this work could exhibit NLO activity thanks to the intrinsic disorder that generates local asymmetry.
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips
Authors: Grant Jennifer , Lee Elizabeth , Almeida Micaela , Kim Seongmin , LoGrande Nina , Goyal Girija , Sesay Adama Marie , Breault David T. , Prantil-Baun Rachelle , Ingber Donald E.
Published: March 2022

We describe a simple strategy to achieve physiologically relevant oxygen tension in human Intestine Chips without using premixed gases or specialized incubators.
Chain-ring covalently interconnected cellulose nanofiber/MWCNT aerogel for supercapacitors and sensors
Authors: Wang Duan-Chao , Yu Hou-Yong , Ouyang Zhaofeng , Qi Dongming , Zhou Ying , Ju Anqi , Li Ziheng , Cao Yiwen
Published: March 2022

Carboxylated cellulose nanofibers/aminated multi-walled carbon nanotubes covalently interconnected conductive aerogels were inspired by peptide condensation.
A stretchable ultraviolet-to-NIR broad spectral photodetector using organic–inorganic vertical multiheterojunctions
Authors: Trung Tran Quang , Dang Vinh Quang , Lee Nae-Eung
Published: March 2022

A stretchable broadband photodetector with organic–inorganic vertical multiheterojunctions on a three-dimensionally micro-patterned substrate presents good responsivity to UV, Vis, and NIR light under applied stretching up to 30%.
Observation of high-density multi-excitons in medium-size CdSe/CdZnS/ZnS colloidal quantum dots through transient spectroscopy and their optical gain properties
Authors: Yang Hongyu , Li Si , Zhang Lei , Xiang Wenbin , Zhang Yi , Wang Xiaoyong , Xiao Min , Cui Yiping , Zhang Jiayu
Published: March 2022

The binding energy and lifetime of band-edge biexcitons are influenced by the Coulomb attraction and enhanced dielectric screening effect.
Copper-catalyzed aerobic benzylic C(sp3)–H lactonization of 2-alkylbenzamides via N-centered radicals
Authors: Nozawa-Kumada Kanako , Ono Kanako , Kurosu Satoshi , Shigeno Masanori , Kondo Yoshinori
Published: March 2022

We developed a novel copper-catalyzed benzolactone synthesis via 1,5-HAT of amidyl radicals from 2-alkylbenzamides under O2 atmosphere.
An amino acid-derived ABCBA-type antifouling biohybrid with multi-stimuli responsivity and contaminant removal capability
Authors: Kumar Devendra , Mohammad Sk Arif , Kumar Anand , Mane Shivshankar R. , Banerjee Sanjib
Published: March 2022

We report a multi-stimuli (pH/thermo/redox) responsive (PCysMAM-b-PDMAEMA-b-PB-b-PDMAEMA-b-PCysMAM) pentablock copolymer biohybrid which exhibits antifouling property and contaminant removal capability.
Novel magnetic nickel ferrite nanoparticles modified with poly(aniline-co-o-toluidine) for the removal of hazardous 2,4-dichlorophenol pollutant from aqueous solutions
Authors: Fathy Mahmoud Abdelwahab , Kamel Ayman H. , Hassan Saad S. M.
Published: March 2022

Chlorinated organic and phenolic compounds are still purely studied by many researchers because of their severe damage to the aquatic environment and their carcinogenic effect on many living organisms.
Aptamer fluorescence anisotropy assays for detection of aflatoxin B1 and adenosine triphosphate using antibody to amplify signal change
Authors: Li Yapiao , Yu Hao , Zhao Qiang
Published: March 2022

Aptamer fluorescence anisotropy assays for small molecules (aflatoxin B1 and ATP) using antibody to amplify signal change.
Efficient ambient ammonia synthesis by Lewis acid pair over cobalt single atom catalyst with suppressed proton reduction
Authors: Tran Ngoc Quang , Liu Xinghui , Cho Yunhee , Duy Le Thai , Zheng Lirong , Yu Jianmin , Ajmal Sara , Shao Xiaodong , Lee Jinsun , Lee Hyoyoung
Published: March 2022

A Lewis acid pair over a single Co atom anchored on sponge-like nitrogen-doped mesoporous hollow carbon nanofibers was designed. The catalyst exhibits an NH3 production rate of 67.6 μg h−1 mg−1 and a maximum Faraday efficiency of 56.9% at a peak potential of −0.1 V vs. RHE.
NbN nanodot decorated N-doped graphene as a multifunctional interlayer for high-performance lithium–sulfur batteries
Authors: Ma Fei , Zhang Xiaojuan , Sriniva Katam , Liu Dawei , Zhang Ziheng , Chen Xin , Zhang Wanli , Wu Qi , Chen Yuanfu
Published: March 2022

A NbN nanodot decorated N-doped graphene nanosheet material was fabricated via a simple and efficient microwave-assisted method coupled with an ammonification process.
An efficient PeT based fluorescent probe for mapping mitochondrial oxidative stress produced via the Nox2 pathway
Authors: Baruah Mousumi , Jana Anal , Ali Mudassar , Mapa Koyeli , Samanta Animesh
Published: March 2022

A new pentacyclic pyridinium-based mitochondria-specific fluorescent probe, PM-S, exhibited a specific turn-on fluorescence response towards hypochlorous acid and enabled imaging of oxidative stress in mitochondria through Nox2 activation.
Surface ligand engineering involving fluorophenethyl ammonium for stable and strong emission CsPbBr3 quantum dots and high-performance QLEDs
Authors: Zhang Qiang , Jiang Minghui , Yan Guijun , Feng Yaqing , Zhang Bao
Published: March 2022

Fluorophenethyl ammonium bromide is introduced in the synthesis of CsPbBr3 QDs and the influence of the fluorination position (ortho, meta, and para) at the benzene ring on the optical properties and stability of CsPbBr3 is systematically evaluated.
The role of specific and active surface areas in optimizing hard carbon irreversible capacity loss in sodium ion batteries
Authors: Beda Adrian , Vaulot Cyril , Rabuel François , Morcrette Matthieu , Matei Ghimbeu Camélia
Published: March 2022

The hard carbon irreversible capacity loss in Na-ion cells can be reduced by decreasing the total surface area and the active surface area (defects).
How background music of shopping sites affects consumers during festival season
Authors: Chen Dan , Zhang Xiaoran , Jiang Hanyun , Meng Xiao , Zheng Jun , Sun Lingyun , Zhang Kejun
Published: March 2022

This study focusses on the impact of the background music on consumers' shopping experience during the festival seasons. The authors derived a new research model based on the environmental psychology model in the literature and then designed an empirical experiment to examine changes in consumers' non‐behavioural shopping outcomes under different conditions. The authors built a virtual shopping website and chose a traditional Chinese festival, the Mid‐Autumn Festival, as the experimental scenario in which the authors used a questionnaire to measure the differences in dependent variables formed by different treatments. Data from the online experiment showed that consumers' experience is more positive with music than without the background music, and the consumer's emotions play a mediating role. However, there is no significant effect of music with the theme of the Mid‐Autumn Festival compared to ordinary pop music, which proves that the theme of music does not affect consumers' experience in the online shopping scenario. These findings reflect the psychology and behaviour of consumers when using shopping websites and provide suggestions for shopping site design.
Aircraft trajectory filtering method based on Gaussian‐sum and maximum correntropy square‐root cubature Kalman filter
Authors: Bai Jing G. , Ge Quan B. , Li Hong , Xiao Jian M. , Wang Yuan L.
Published: March 2022

Aiming at meetiing the need to filtering flight trajectory data for aircraft testing, a novel adaptive cubature Kalman filter (CKF) is proposed based on the maximum correntropy and Gaussian‐sum in this paper. Firstly, based on the traditional CKF algorithm, we introduced a Gaussian‐sum method to approximate non‐Gaussian noise to get more accurate filtering results in view of the problem of reduced filtering accuracy caused by the inherent non‐Gaussian nature of the noise and the system non‐linearity. Secondly, the maximum correntropy criterion is introduced to solve further the problem of improving the filtering accuracy of the system in the case of non‐linearity. Simulation results and actual data verification showed that the Square‐root cubature Kalman filter algorithm based on the maximum correntropy and Gaussian‐sum has higher accuracy than traditional filtering algorithms, which verified the algorithm's effectiveness in the application.
Data‐driven consensus control for a class of unknown nonlinear multiagent systems with time delays
Authors: Liu Shida , Li Jiancheng , Wang Li , Hou Zhongsheng , Ji Honghai
Published: March 2022

In this paper, the distributed output consensus tracking problem for a class of unknown heterogeneous discrete‐time single‐input single‐output nonlinear multiagent systems (MASs) with time delays is considered. For this problem, a distributed data‐driven consensus control strategy is proposed by using improved model‐free adaptive control with a time delay. First, the unknown nonlinear multiagent time delay system is transformed into a virtual data model with time‐varying parameters by using a partial form dynamic linearisation method. Then, a controller with model‐free adaptive control and a tracking differentiator are designed. The proposed method uses only the input/output data of neighbouring agents during the control process without mathematically modelling multiple agents. For the time delay system, the boundedness of the closed‐loop tracking error is theoretically proven for both the tracking problem and the regulation problem. Furthermore, this result can be generalised to switching topology structures by a rigorous mathematical proof. Numerical simulations verify the effectiveness of the proposed algorithm.
Active and reactive power control of grid‐connected single‐phase asymmetrical eleven‐level inverter
Authors: Tayyab Mohammad , Sarwar Adil , Murshid Shadab , Tariq Mohd , Al‐Durra Ahmed , Bakhsh Farhad Ilahi
Published: March 2022

In recent times, multilevel inverters (MLIs) have become very popular for commercial and industrial applications. Here, an eleven‐level inverter and its power flow control are presented. The presented topology has a lesser component count than other existing topologies, thus reducing the devices and overall cost of the inverter. This inverter comprises six bidirectional switches, two DC sources, one four‐quadrant switch, and two capacitors for the voltage divider circuit. The conduction modes and corresponding switching states of the presented eleven‐level inverter are shown in detail. Further, the apparent power control of the presented inverter under grid‐connected operation is discussed, which provides simultaneous active and reactive power control over the power injected into the grid. Switching and conduction losses are calculated for 3 and 6 kVA grid injected power at 0.8 power factor lagging. The obtained results show that the total harmonic distortion (THD) of the inverter output voltage and grid current is 12.10% and 0.23%, respectively, under 6 kVA power transfer conditions. The real‐time analysis is also carried out for 3 and 6 kVA power transfer conditions for the presented eleven‐level inverter to validate the active and reactive power flow control.
Translational motion estimation and compensation in distributed inverse synthetic aperture radar imaging of ship target with complex motion
Authors: Zhang Junqiu , Wang Yong
Published: March 2022

A translational motion estimation and compensation method is proposed based on the parametric method by multiple stations in the distributed inverse synthetic aperture radar (ISAR) imaging. For ship targets with complex motion, the distributed ISAR increases the cross‐range resolution of the image by expanding the observation angle. However, the translation compensation methods by a single station will destroy the correlation between the echoes, which reduces the image quality, and a more accurate joint translation compensation method is required. Multi‐static observation is obtained in the Distributed system, which we can utilise in the parameter estimation: 1) joint Doppler estimation, 2) station angle estimation, and 3) rotation velocity estimation. Based on the above estimations, the velocity vector and the acceleration vector of the target can be obtained, and then the translational motion compensation can be realised parametrically. The algorithm processing chain is presented in this paper. Finally, the numerical simulations with four stations are presented to verify the effectiveness and the robustness of the proposed algorithm.