bluuebunny/crossref_metadata_2025 huggingface dataset:
Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson’s disease patients: A prospective cohort study (HP-PD trial)
Authors: Lolekha Praween , Sriphanom Thanakarn , Vilaichone Ratha-Korn
Published: May 2021

Background

Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson’s disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response and decrease motor fluctuations.

Methods

A prospective cohort study was conducted on the clinical symptoms of PD patients with motor fluctuations. The 13C-urea breath test was used to diagnose a current HP infection. All patients with HP infection received a 2-week regimen of triple therapy. The changes in the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score, L-dopa onset time, wearing-off symptoms, mean daily on-off time, GI symptom scores, and quality of life score were measured at baseline and at a 6-week follow-up.

Results

A total of 163 PD patients were assessed, of whom 40 were enrolled. Fifty-five percent of the enrolled patients (22/40) had a current HP infection, whereas HP eradication was identified in 17 of 22 (77.3%) patients who received eradication therapy. Patients with HP eradication showed a significant decrease in daily ‘off’ time (4.0 vs. 4.7 h, p = 0.040) and an increase in daily ‘on’ time (11.8 vs. 10.9 h, p = 0.009). Total wearing-off score (4.4 vs. 6.0, p = 0.001) and the GI symptom score (8.1 vs. 12.8, p = 0.007) were significantly improved. There was no significant improvement in L-dopa onset time, UPDRS motor score, or quality of life score.

Conclusions

HP eradication leads to significant clinical improvement in the symptoms of PD. Eradication of HP not only increases the total daily ‘on’ time but also decreases wearing-off symptoms and improves GI symptoms.
Objeto de aprendizagem sobre cultura digital: fake news e filtros bolha
Authors: Rocha de Oliveira Gabriel , Victoria Viana Aguiar Odakura Valguima
Published: May 2021

In a society inserted in the digital environment, where childrenare exposed daily to different types of content, there is a need toguide children, especially in relation to digital citizenship. In thiscontext, this work aims to develop a Learning Object (LO) that helpsdiscuss fake news and bubble filters in a playful way, encouragingelementary school children to have a critical view on the topic.To qualify whether this LO achieved its objective, two methodsof evaluation were used with the intention of verifying whetherthe proposed LO fulfills its role in raising the target audience’sawareness.
Uma Análise de Critérios de Acessibilidade em Interfaces web de Jogos de Segurança Computacional
Authors: Augusto Ueno Otto Vítor , De la Rocha Ladeira Ricardo
Published: May 2021

The expressive amount of people with disabilities makes the accessibilitytheme increasingly important. However, this relevancecontrasts with the significant inaccessibility in the world. On theweb this is no different, despite the existence of solid accessibilityguidelines, such as WCAG. The same thing happens in ComputerSecurity game interfaces, which can be used as pedagogical toolsfor teaching this area with increasing demand for professionals.Therefore, this paper aimed to analyze web interfaces of ComputerSecurity games, among them TreasureHunt, object of the authorsresearch work; thereby It was possible to identify which WCAGguidelines were followed in those interfaces and improve the accessibilityof TreasureHunt. For such, manual validations of theWCAG’s 87 accessibility guidelines in version 2.1 and drafts ofversion 2.2 were used, as well as automatic validations of HTML,CSS and accessibility. As a result, the TreasureHunt interface met78% of the accessibility guidelines and passed the three automaticvalidators, while the other tools had an average of approximately30% of the guidelines met and didn’t pass the HTML validator
Australian Early Childhood Teachers’ Training in Language and Literacy: A Nation-Wide Review of Pre-Service Course Content
Authors:   La Trobe University, Bendigo Campus, Victoria, Weadman Tessa , Serry Tanya ,   La Trobe University, Bendigo Campus, Victoria, Snow Pamela C. ,   La Trobe University, Bendigo Campus, Victoria
Published: May 2021

Early childhood teachers are well-positioned to maximise preschoolers’ development in oral language and emergent literacy; both of which are vital predictors of academic success at school. Research investigating their pre-service training in language and emergent literacy remains limited. This issue is addressed in the present study, with the first nation-wide review of the oral language and emergent literacy course content across all 84 Australian early childhood teacher pre-service courses. Qualitative Content Analysis was employed to gain an overview of language and emergent literacy teaching content reported in publicly available course documents. Study findings demonstrated large variation in the oral language and emergent literacy course content reported. The results showed that course content on the structure of language and code-related skills including phonological awareness and concepts of print, do not feature prominently across pre-service course documents. Further, course content on evidence-based strategies to foster children’s oral language and emergent literacy development, such as dialogic book reading, and intentional adult-child interactions were also limited. Findings are discussed with respect to their implications for preparing early childhood teachers to support the oral language and emergent literacy growth of preschoolers.
Molecular Evolutionary Characteristics of the 2019 Novel Coronavirus (SARS-CoV-2) Contracted by Tunisian Citizens: Comparison and Relationship to Other Human and Animal Coronaviruses Based on Spike Glycoprotein-Coding Gene Sequences Analysis
Authors: Boulila Moncef
Published: May 2021

In contributing to the initiative to address the COVID-19 pandemic and in order to enhance the knowledge on driving forces shaping the evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (isolated from Tunisian patients), a comparison in relation to other coronaviruses infecting humans (SARS-CoV-1, MERS-CoV, HCoV/229E, HCoV/NL63, HCoV/OC43, and HCoV/HKU1) as well as animals (SARS-CoVs in tiger, bats, civet, pangolin, bovine, and MERS-CoV in dromedary/camel), was conducted. In-depth analysis was carried out involving 115 sequences of spike glycoprotein-coding gene extracted from the international databases. Phylogeny inference allowed the reconstruction of a bifurcating tree where four distinct groups were delineated and at the same time, three animal accessions (SARS-CoV-2/tiger, MERS-CoV/camel, and SARS-CoV/bovine) shifted from the animal group and integrated the human coronaviruses clades. Nonetheless, in the presence of reticulate events such as recombination, networks described better the phylogenetic relationships rather than the classic dendrogram. Thus, networks were produced and identified four clusters containing sharply demarcated subgroups (eight subdivisions). Except networked phylogenies of SARS-CoV-1, SARS-CoV-2, and HCoV/HKU1, all the others showed edges and boxes illustrating the occurrence of incompatibilities related to the sequences of spike glycoprotein-coding gene. Thereby and consolidating this result, three methods (RDP package, GARD, and RECCO) were used to detect breakpoints in aligned sequences. Except the clades SARS-CoV-1 and SARS-CoV-2, all the remaining phylogenetic subdivisions were subject to recombination. Furthermore, the screening of selection pressure in all studied sequences by various statistics-based models of the HyPhy package, showed that, similarly, the lineages belonging to the clades SARS-CoV-1 and SARS-CoV-2 were not under selection. In contrast, all members of the remaining clades underwent, to different extents, adaptive selection as well as purifying selection.
Russomania: Russian culture and the creation of British modernism, 1881-1922 (2020)
Authors: Bretan Juliette
Published: May 2021

N/A
RECURSOS FITOGENÉTICOS FORESTALES, FORRAJEROS, DE INTERÉS APÍCOLA Y PAISAJÍSTICO NATIVOS DE LA PROVINCIA DE SANTA FE (ARGENTINA)
Authors: ZABALA J. M. , EXNER E. , CERINO C. , BUYATTI M. , CUFFIA C. , MARINONI L. , KERN V. , PENSIERO J. F.
Published: May 2021

Santa Fe posee un número signiﬁcativo de especies nativas con valor real o potencial para la producción agropecuaria, industrial y la protección ambiental. El primer paso para desarrollar una estrategia de uso eﬁciente de los recursos genéticos silvestres es el listado de las especies prioritarias a conservar. En este trabajo se analizan los recursos ﬁtogenéticos forrajeros herbáceos, forestales, de interés apícola y paisajístico dada su importancia económica y/o estratégica. Se brinda información de uso en cada categoría y en todas las especies se analiza su distribución geográﬁca por departamentos y se presenta información sobre la conservación de sus semillas. Se priorizaron 138 especies, 29 de las cuales tienen más de un uso (24 de interés forestal, 45 de interés forrajero, 32 de interés apícola y 69 de interés paisajístico). La información que se presenta será de utilidad en el diseño de estrategias de conservación y uso de los recursos ﬁtogenéticos nativos por parte de investigadores y organismos oﬁciales provinciales y nacionales.
Differences In The Reading Comprehension Ability Of Students In The PQ4R Learning Model For Indonesian Language Subjects
Authors: Rahmawati Puji , Susanti Hamdiah , Selestin Yulia Deodata , Mustajab Amin
Published: May 2021

The purpose of this research is to determine students' reading comprehension skills before and after using the PQ4R learning model. This research was motivated by preliminary studies, which showed that students' reading comprehension skills are still low in conventional learning models. This is a quantitative research consisting of a one-group pretest-posttest research design. Data were obtained from 22 students of state elementary school 03 Sontas using a written test of 6 (six) questions. The research showed differences in students' reading comprehension skills before and after learning using the PQ4R model.
Developing Communicative-Based Instructional Model Of Speaking Skill In Elementary School
Authors: Muammar Muammar , Suhardi Suhardi , Mustadi Ali
Published: May 2021

This study aims to develop a communicative-based instructional speaking skill model, in respect to experts' validation, practicality, and effectiveness in learning. The learning process was generated due to the unavailability of an instructional speaking skill model, which was predicted to help students verbalize their thoughts, ideas, and feelings. The method used was research and development (R&D) technique, while the subjects included five experts/teachers and 26 students selected in the elementary school. Data collection were carried out through scale, observation, tests, and distribution of questionnaires, as well as analyzed descriptively and statistically, using a t-test method. The results showed that, the communicative-based instructional speaking skill model was practical, effective in improving students'verbal ability, and considered valid by the experts.
“Notes and Letters”: Music of the City in Flight / Trans-Migratory Poetry. By Antonio Monte Casablanca. Translated by Crystal Neill, with Amanda Minks and Lila Ellen Gray.
Authors: Monte Casablanca Antonio , Neill Crystal
Published: May 2021

In this essay I draw from memory studies and Latin American cultural studies to reflect on Notas y Letras (Notes and Letters), a collaboration by the Nicaraguan band Nemi Pipali and the poet Adolfo Beteta. I analyze these artistic expressions, music and poetry, at their place of convergence—the city of Managua—making audible some of the mechanisms that combine symbolic universes in Nicaraguan culture. This transdisciplinary reading allows me to propose that 1) music becomes a social marker of performative memory, transmitted by sounds present in hybrid Latin American cities, and 2) the migrant subject is displaced and divided between the center and the periphery.
Citation: Monte Casablanca, Antonio. “Notes and Letters”: Music of the City in Flight / Trans-Migratory Poetry. Translated by Crystal Neill, with Amanda Minks and Lila Ellen Gray. Ethnomusicology Translations no. 11. Bloomington, IN: Society for Ethnomusicology, 2021.
Originally published in Spanish as “‘Notas y Letras’: Música de la ciudad en fuga / Poesía transmigratoria.” Revista de Historia (Instituto de Historia de Nicaragua y Centroamérica) 33/34 (2015): 108-129.
Formation of the Enterprise Strategy based on the Industry Life Cycle
Authors: Karpenko Yuliia , Kuznetsova Inna , Chykurkova Alla , Matveyeva Maryana , Hridin Oleksandr , Nakonechna Kateryna
Published: May 2021

The article considered the process of forming an enterprise strategy in the following stages: analysis of the external and internal environment of an enterprise, formation of a system of enterprise goals, assessment of alternative development strategies and the choice of one of them, implementation of the chosen strategy, and adjustment of the strategy. It is proposed to analyze the external environment in accordance with the concept of the industry life cycle. The concept of the life cycle of the industry, in particular the main stages of development of the industry and the criteria that are the basis for their identification, has been investigated.  It is proposed to use the scientific developments of Porter and use the following characteristics as criteria: behavior of buyers of products (services), changes in goods, the nature of competitive relations in the market, profits of enterprises in the industry and marketing activities. Accordingly, it is proposed to highlight the stages of the industry development: implementation, growth, maturity, decline.  Alternative strategies of enterprise development at various stages of the industry life cycle are considered: the strategy for realizing the advantages of the pioneer, the strategy of change response, the strategy of change management, the strategy of stabilization, the strategy of reduction, the strategy for finding segments of steady demand, as well as the strategy of the "last time". The main characteristics of these strategies are studied. The analysis of the life cycle of the agricultural industry in Ukraine has been carried out and it has been established that according to most of the characteristics it is at the stage of maturity. The industry has established relationships between producers and business consumers, enterprises receive average profits and specialize in the production of certain types of agricultural products of sufficiently high quality, and there are processes of gradual ousting of competitors from the market.  It is proposed to agricultural enterprises as a possible strategy to implement a stabilization strategy that best suits the conditions of the external environment.
Peculiarities of Implementation of Configuration Control Processes of Integrated and Innovative Projects of Logistics System Creation
Authors: Тryhuba Inna , Ivanyshyn Olexandr , Chaban Vitalii , Horobchenko Oksana , Zaika Olena , Semenyshyna Iryna
Published: May 2021

The analysis of the current scientific and methodological principles of project management is performed. It is established that the existing models and methods cannot be used to control the configuration of integrated projects for the creation of logistics systems. The known toolkit provides general approaches to controlling the configuration of projects and does not take into account many factors of the design environment, which determine changes in the configuration of integrated projects for creating logistics systems. It has been substantiated that changes in the configuration of integrated projects for the creation of logistics systems are due to two groups of factors. They can be assessed by four criteria based on the determination of two generalized evaluative characteristics of the influence of the factors of the design environment on changes in the configuration objects of these projects. The scientific and methodological foundations of the configuration control of integrated projects for the creation of logistics systems are proposed, taking into account the changing components of their design environment. To control the configuration of integrated projects for the creation of logistics systems, the use of project management theory and system-factor principles is envisaged, which fully take into account the peculiarities of the implementation of these projects. Based on the proposed model, the impact of internal environment factors of integrated projects for the creation of logistics systems on changes in the configuration object No. 4.1 (a specialized tank truck for transporting perishable goods) was assessed. Significance coefficients are defined for each of the assigned codes (evaluation criteria and factors that determine the configuration changes) of the configuration objects of integrated projects for the creation of logistics systems. Their numerical value is in the range 0…1 and it characterizes the significance of each of the factors for a particular object of the configuration of integrated projects for the creation of logistics systems. Quantitative assessment of the impact of design environment factors on changes in the configuration of integrated projects for the creation of logistics systems is carried out on a 100-point scale.
An improved parallel sub-filter adaptive noise canceler for the extraction of fetal ECG
Authors: Jaba Deva Krupa Abel , Dhanalakshmi Samiappan , R Kumar
Published: May 2021

Non-invasive extraction of fetal electrocardiogram (FECG) by processing the abdominal signals is emerging as a promising approach in the areas of obstetrics and gynecology. This paper presents a two-stage improved non-linear adaptive filter for FECG extraction. The reference input to the adaptive noise canceler (ANC) is first processed using an adaptive neuro-fuzzy inference system (ANFIS) to estimate the non-linear maternal component in abdominal signals. A parallel sub-filter (PSF) ANC is proposed to assess the fetal ECG from the abdominal signal. The PSF-ANC decomposes a single adaptive filter into multiple sub-filters to improve the convergence performance. The filter coefficients of PSF-ANC adaptively obtained using normalised least mean square algorithm by minimizing the mean square error. Different error and common error algorithms are proposed based on the computation of the error signal. A synthetic data from the FECG synthetic database is used to evaluate the convergence performance. Two real-time data from the Daisy database and the Non-invasive FECG database from Physionet are used to evaluate the proposed ANFIS-PSF’s performance qualitative and quantitatively. The results justify the performance improvement of proposed ANFIS-PSF ANC compared to the state of art techniques. The proposed scheme achieves a sensitivity of 97.92%, 94.52% accuracy, a positive predictive value of 94.66%, and an F1 score of 96.12%.
Vergleichende Bewertung von Algorithmen zur Lokalisierung von Flammen und Glut
Authors: Stoller Fabian , Kümmerlen Felix , Fay Alexander
Published: May 2021

Die Zulassung von Feuerlöschern erfordert die Durchführung von Versuchen für den Nachweis des Löschvermögens eines Feuerlöschermodells. Damit dieser Versuch unabhängig von den Fähigkeiten menschlicher Löschmeister ist, soll die Durchführung automatisiert werden. Dafür wird der Stand der Forschung auf Algorithmen untersucht, die mithilfe einer Farb- und einer Infrarotkamera Flammen und Glutnester lokalisieren können. Diese Informationen sollen genutzt werden, um den Löschversuch effektiv und effizient durchzuführen. Dafür werden in diesem Beitrag sechs Algorithmen zur Lokalisierung von Flammen in Farbbildern und drei Algorithmen zur Lokalisierung von Glut in den Bildern einer Infrarotkamera anhand der Kriterien Sensitivität, Falsch-Positiv-Rate, Intersection over Union und durchschnittlicher Ausführungsdauer verglichen. Anhand des Ergebnisses des Vergleichs wird jeweils ein Algorithmus für das automatisierte Löschen des Normbrandversuchs ausgewählt.
Stitched open-loop measurements with a focal-distance-modulated confocal sensor
Authors: Schaude Janik , Gröschl Andreas Christian , Hausotte Tino
Published: May 2021

The article presents measurements with a high-speed focal-distance modulated fibre-coupled confocal sensor integrated into a nano measuring machine (NMM-1). Combined with an appropriate signal processing, this axial beam modulating sensor yields a linear characteristic curve within a range of about 600 nm. This characteristic curve enables scans in closed-loop constant distance mode, where the controller of the NMM-1 keeps the distance between the measured surface and the sensor constant. Therefore, only one lateral scan is necessary to measure a given topography. Nevertheless, it is also possible to conduct open-loop constant height measurements on discrete heights. The axial offset between the heights needs to be only slightly less than the measuring range of the sensor, leading to a great reduction of the number of needed lateral scans to measure a given topography compared to a conventional confocal sensor, where the axial offset for a similar optical system is typically about 50 nm. To combine the scans taken at different heights, it is possible to stitch them using overlapping measuring points taken at two adjacent heights. Within this article, measurements are conducted on a roughness standard in closed-loop constant distance and in open-loop constant height mode, where the latter are evaluated with and without the application of the stitching algorithm.
Anaesthesia for Awake Fiberoptic Intubation: Ultrasound-Guided Airway Nerve Block versus Ultrasonic Nebulisation with Lignocaine
Authors:   Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, Mohanta Jharana , Kumar Ajit ,   Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, Kaushal Ashutosh ,   Department of Anaesthesiology, All India Institute of Medical Sciences, Bhopal, M.P., India, Talawar Praveen ,   Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, Gupta Priyanka ,   Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, Jain Gaurav ,   Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Published: May 2021

Background: In anticipated difficult airway, awake fiberoptic guided intubation should be the ideal plan of management. It requires sufficient upper airway anesthesia for patient’s comfort and cooperation. We compared the efficacy of ultrasound guided airway nerve blocks and ultrasonic nebulisation with lignocaine for airway anesthesia before performing awake fibreoptic guided intubation. Methods: This prospective, randomised study included sixty consenting adult patients of both genders (American Society of Anesthesiologists' physical status 1–3) with anticipated difficult airway undergoing surgery. Ultrasound guided airway nerve blocks group received ultrasound-guided bilateral superior laryngeal (1 ml of 2% lignocaine) and transtracheal recurrent laryngeal (2 ml of 2% lignocaine) airway nerve blocks and ultrasonic nebulisation with lignocaine group received ultrasonic nebulisation of 4 ml of lignocaine 4%. The primary outcome was to compare the time required to intubate, whereas the secondary outcomes were to compare cough reflex and gag reflex, hemodynamic changes, number of attempts required, and comfort score during awake fibreoptic guided intubation in both the groups. Results: The time taken for intubation was significantly lower in the ultrasound guided airway nerve blocks group 69.2721.85 s than ultrasonic nebulisation with lignocaine group 92.43  42.90 s (p = 0.015). Hemodynamic variables changed during the procedure but the values were comparable in both groups. There were no statistical differences in cough and gag reflexes, number of attempts, and comfort score in both groups. Conclusions: This study shows that significant lesser time required for performing awake fiberoptic intubation when patient received ultrasound guided airway nerve block in comparison to ultrasonic nebulisation for airway anaesthesia.
Temporality, Space, and Networks in Indo-Pacific Environmental Histories
Authors: Bennett Brett M. , Barton Gregory A.
Published: May 2021

This special issue of Pacific Historical Review, “Crossroads of Indo-Pacific Environmental Histories,” is guest edited by Gregory A. Barton and Brett M. Bennett. The special issue explores how environmental historians can use the concept of the Indo-Pacific to understand both the deep and contemporary histories of regions that are frequently viewed through Indian Ocean world or Pacific Ocean world perspectives. A preface and this introduction provide a theoretical overview, establishing some of the key temporal, spatial, and causal parameters of the Indo-Pacific. The following articles by Timothy P. Barnard, by Ruth Morgan, and by Gregory Barton and Brett Bennett highlight how local and foreign powers have sought to control the Indo-Pacific’s natural resources to shape new economies, ecologies, and polities within the region during the past two centuries. Broadly, the special issue encourages other historians to engage with the Indo-Pacific concept due to its theoretical depth as well as its relevance to contemporary geopolitical affairs.
American Dream Deferred
Authors: Paligutan P. James
Published: May 2021

This article examines a unique migratory movement of Filipinos to America: Filipino nationals recruited by the U.S. Navy and Coast Guard between 1952 and 1970. Such recruits were seen as a solution to a mounting labor problem stemming from the Navy’s traditional use of minorities to fulfill duties as servants for naval officers. With African Americans' demands for equal opportunity reaching a crescendo during the Civil Rights era, the U.S. Navy looked to its former colony to replenish its supply of dark-skinned servants. Despite expectations of docility, however, such Filipino sailors were able to forge a culture of resistance manifested through non-confrontational acts of defiance, protest through official channels, and labor stoppage. Such actions ultimately resulted in the reversal of naval policy that relegated Filipinos to servile labor.
Endoscopic Ultrasound-guided Radio-frequency Ablation for Pancreatic Cancer
Authors: Kongkam Pradermchai , Rerknimitr Rungsun
Published: May 2021

Prognosis of unresectable pancreatic cancer is poor with the rate of surviving more than 5 years is less than 10% despite multi-modalities treatment. The American Society of Clinical Oncology suggested that all patients with metastatic pancreatic cancer should be offered information about clinical trials. Endoscopic ultrasound guided radio frequency ablation has been recently used in patients with advanced stage pancreatic cancer in a few studies. This article has reviewed information from published articles using endoscopic ultrasound guided radio frequency ablation for advanced pancreatic cancer.
Identification and support of gifted children within the framework of school-university networks
Authors:   Sochi State University, Maznichenko Marina Aleksandrovna , Neskoromnykh Nataliya Ivanovna ,   Creativity and Humanitarian Education Center in Sochi, Sadilova Oksana Pavlovna ,   Sochi State University, Brevnova Snezhana Vladimirovna ,   Sochi State University, Grigorashchenko-Aliyeva Nadezhda Mansumovna ,   Sochi State University, Fomenko Vita Alexandrovna ,   Sochi State University
Published: May 2021

Introduction. The article examines the potential of school-university partnership programmes for gifted and talented children. The purpose of this study is to determine the mechanisms for identifying and supporting gifted children by means school-university networks. Materials and Methods. To achieve this goal, the authors have reviewed a considerable amount of literature on giftedness, identification and support of gifted children with a focus on establishing school-university networks. A sample of leadership and teaching staff (n = 149) representing 44 municipalities of the Krasnodar Krai (Russian Federation) was surveyed in order to evaluate the effectiveness of identification, support and guidance of gifted students. The analysis of university websites was carried out in order to reveal the existing practices of partnerships with secondary and supplementary education settings aimed at identification and support of gifted children. To solve the revealed problems of gifted education, a model of school-university network encompassing the flagship university and secondary and supplementary education settings has been developed. Results. The study has revealed the following problems of provision for gifted and talented students: unrecognized special giftedness; underestimation of career guidance for gifted students; insufficient attention to social and emotional issues in the development of gifted children; lack of continuity in provision for gifted and talented individuals at different levels of education. The authors propose a model of the network between the flagship university and secondary education settings aimed at solving the above mentioned problems. The research findings include procedures of identifying and supporting gifted children by means of school-university partnership programmes for 9 domains of giftedness (academic (intellectual), technical, entrepreneurial, communicative, leadership, emotional, sports, artistic and vocational) in corresponding types of career-oriented activities (educational, research, scientific; technical design, business design, business communication, management, volunteering, sports, artistic creativity, production) using the facilities and human resources of the flagship university. Conclusions. The conclusion can be drawn that identification and support of gifted children and adolescents must be carried out in close connection with career guidance, taking into account the needs of the regional labor market. Building partnerships of the university, comprehensive secondary schools and supplementary education settings contribute to solving this problem.
Research on information awareness of teachers working with children with severe and multiple developmental disabilities in Armenia
Authors:   H. Abovyan Armenian State Pedagogical University, Azatyan Tereza Yurevna , Aslanyan Anush Arturovna ,   H. Abovyan Armenian State Pedagogical University
Published: May 2021

Introduction. As in many countries, in Armenia the problem of providing psychological and pedagogical assistance to families and teachers of children with severe and multiple developmental disabilities is still insufficiently developed. Based on the research results and practical evidence, recommendations for teachers on adjustment of disabled children to school environment are presented. Materials and Methods. The research methodology is based on previous international studies on the role of teachers' attitudes to children with severe and multiple developmental disorders, as well as difficulties in their socialization /Chulkov, V. N.; Golovchits, L. A.; Basilova, T. A., etc./. The model of remedial educational, psychological, technical and social interventions has been developed. Results. The results indicate that the institute of rehabilitation care for children with severe and multiple developmental disabilities is not fully established in Armenia, especially within inclusive education. Moreover, there is no uniformed approach to this problem. Revealing difficulties of teachers working with children with severe and multiple developmental disabilities in Armenia will allow to conduct primary educational diagnostics, adjust the content and methods of working with these children to their special educational needs, and design supportive educational environment. Conclusions. The findings indicate the need for systematic assistance to teachers working with children with severe and multiple developmental disabilities to identify difficulties within the educational process, close cooperation with multidisciplinary teams or professionals from resource centers, which, in its turn, contributes to the creation of a unified system of assistance to teachers working with children with severe and multiple developmental disabilities in Armenia.
Pembelajaran Kanji Menggunakan Metode Flipped classroom dengan Media Online “Tanoshiijapanese.com” dalam Meningkatkan Kemandirian Belajar Siswa
Authors: Karyati Alo , Rahmawati Yelni
Published: May 2021

Dalam pembelajaran huruf Bahasa Jepang terdapat 3 huruf yang harus dipelajari, yaitu: Huragana, katakana, dan kanji. Dari ketiga huruf tersebut kanji merupakan huruf yang paling sulit. Pemebelajaran kanji ini selalu dipandang para pembelajar, karena penulisannya yang rumit. Karena penulisan yang rumit tersebut banyak siswa yang tergantung pada pengajar di setiapa kegiatan perkuliahan/pembelajaran. Pengajar menulis, siswa mengikuti apa yang ditulis pengajar.  Sehingga membuat siswa kurang memiliki kemandirian.  Berdasarkan hal tersebut peneliti mencoba mempraktekan metode pembelajaran Flipped class pada kelas  kanji semester V Universitas Pakuan. Dalam proses pembelajarannyan pengajar menyuruh siswa menyiapkan kunyomi dan onyomi, menulis alur penulisan kanji, mencari jukugo  dari setiap unit kanji di setiap perkuliahan dimulai. Tugas diberikan 3 hari sebelum kegiatan perkuliahan. Rumusan masalah pada penelitian ini adalah: (1) Apakah metode Flipped class menggunakan media online “tanoshiijapanense.com” dapat meningkatkan kemandirian siswa  dalam belajar kanji? (2) Apakah metode flipped class menggunakan media online “tanoshiijapanese.com cocok diterapkan dalam pembelajaran kanji? (3) Kendala apakah yang dihadapi mahasiswa selama  belajar menggunakan  metode Flipped class dengan media online “tanoshiijapanese.com” sebagai media pembelajarnya. Populasi dalam  penelitian adalah mahasiswa semester 5 Universitas Pakuan, sampel penelitiannya berjumlah 21 orang. Metode penelitian yang digunakan adalah metode analisis deskriftif. Teknik Pengumpulan data menggunakan google form, terdiri dari 5 kalimat pernyataan, dan 5 pertanyaan wawancara.  Analisis data diambil grafik dari google form. Hasil dari penelitian ini diharapkan dapay bermaanfaat bagi semua pengajar Bahasa Jepang baik  yang mengajar matakuliah  kanji di prodi Sastra Jepang Universitas Pakuan, maupun pengajar kanji di berbagai Universitas yang ada di Indonesia.
The Effect of Tourism Experience on Revisit Intention through Destination Image and Satisfaction
Authors: Atmari Noveliana Violla , Putri Vini Wiratno
Published: May 2021

The purpose of this study to examine the influence of tourism experience on revisit intention mediated by destination image and satisfaction. Sampling technique using the accidental sampling and purposive sampling with sample of 240 respondents. Respondents were taken from visitors who had been to Sanggaluri Park Purbalingga twice or more and aged 17 years or over. Method of data collection using the questionnaire. The data analysis method uses the Structural Equation Model - Partial Least Square (SEM-PLS) with the Smartpls program. The direct test result show the result of tourism experience has a direct effect on destination image, tourism experience has a direct effect on satisfaction, tourism experience has a direct effect on revisit intention.
Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study
Authors: Kmochova Klara , Grega Tomas , Ngo Ondrej , Vojtechova Gabriela , Majek Ondrej , Urbanek Petr , Zavoral Miroslav , Suchanek Stepan
Published: May 2021

Background and Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents.
Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability.
Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores ≥6 and sub scores ≥2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores ≥ 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024).
Results of coronary artery bypass grafting in patients with chronic obstructive lung disease
Authors: IF Shlyk , RV Sidorov , VN Shchetko , LP Sizyakina , SV Shlyk
Published: May 2021

This work is relevant because it studies the effect of chronic obstructive pulmonary disease on the incidence of complications after coronary artery bypass grafting in patients with ischemic lung disease. 118 histories of patients, who underwent CABG under conditions of artificial circulation and without it, on a working heart, were analyzed. It was found that in patients with CABG under conditions of infarction and concomitant chronic obstructive pulmonary disease, the period of artificial ventilation was significantly longer among all the assessed complications and features of the postoperative period than in the group of patients with CABG performed on a working heart.
A correlation exists between normal breathing rate and watching horror movies
Authors: Asif Muhammad , Qadir Muhammad Imran
Published: May 2021

The reason of present research was to estimate somewhat relation between normal breathing rate and watching horror movies. Total 135 subjects were the participants of this project. The breathing rate is expressed as the total number of breaths a person receiving in 1 minute. The normal rate is 12 to 20 breaths per minute in adults. The respiration rate underneath 12 and overhead 25 is regarded as abnormal and it points to grim health problems. The situations that can vary normal respiratory rate are anxiety, fever, flu, air pollution, asthma, pneumonia, heart failure, lung disorder, drug overdosing and usage of narcotics. Now a days, number of people love viewing horror movie while some hatred them. There is an elongated list of such movies on internet. Scary movies have the physical and psychological effects on one’s mind. The most evident are anxiety and stress that can lead to high pulse rate and sweating. Such physical effects result in increase of respiration rate. In such situations, we inhale more oxygen and exhale more carbon dioxide. The member of the audience spots high breathing like performing a light exercise. The thrill of unknown and abrupt appearance of any terror initiates the body to groom against that fear. After-all above procedure, it was summarized that there was a significant interaction between normal breathing rate and watching horror movies.
Benefit and clinical characteristics after the use of nintedanib in idiopathic pulmonary fibrosis
Authors: José Carlos Herrera-García , Montellano Ek Ixel Arellano , Luis Enrique Jaramillo Arellano , Arellano Andrea Espinosa
Published: May 2021

Introduction: Nintedanib is an approved antifibrotic agent for the treatment of idiopathic pulmonary fibrosis. (FPI) as monotherapy. To date, the evidence supports its effectiveness in this type of patients. Methodology: We present the case of a Mexican patient of 69 years with Idiopathic Pulmonary Fibrosis (IPF) treated with nintedanib for 52 weeks as monotherapy in a university hospital. Results: Before the 52 week period. There was a clear decrease in the patient's forced vital capacity (FVC) from 70% (2.14L) to 60% (1.83L). The treatment with nintedanib was initiated for a period of 12 months at a dose of 150 mg VO every 12 hrs. Lung function stabilized increasing from 60% (1.83L) to 70% (2.14L), the treatment was well tolerated. Only with presence of mild adverse effects without repercussions. Conclusion: We describe the successful case of a patient with Idiopathic Pulmonary Fibrosis after 52 weeks of treatment with Nintedanib, well tolerated with improved lung function, until now the antifibrotic therapy represents a safe and therapeutically option as monotherapy.
Alpha 1 antitrypsin deficiency: a rare allele in patients from south of Italy
Authors: V Maddaloni , N Pepe , F Morano , M Lanzo , D Darco , L Atripaldi
Published: May 2021

Congenital α1-antitrypsin deficiency (AATD) is an autosomal recessive disorder, in Italy it is estimated that 1 in 5000 individuals may suffer from severe AATD. The AATD pathogenesis is directly related to gene mutations, which are highly polymorphic: in fact, more than 120 genetic variants closely associated with specific plasma glycoprotein concentrations have been identified. All the variants have a different clinical significance as they can cause an increase of occurrence of some pathologies such as emphysema, acute or chronic liver disease, cirrhosis, or liver failure. In particular, emphysema affects 54% of patients diagnosed with this deficit. The purpose of our study was to perform a mutational analysis of the AAT gene in order to highlight a genotype-serum correlation of AAT: we found subjects heterozygous for the rare allele PiMProcida and correlated its presence with a marked lowering of serum AAT levels.
Influence of chronic obstructive illness of the lungs on the current of the postpericardicotomy syndrome in patients after coronary artery bypass grafting
Authors: IF Shlyk , RV Sidorov , VN Shchetko , LP Sizyakina , SV Shlyk
Published: May 2021

One of the complications of aortocoronary bypass surgery is post-pericardiotomy syndrome, the development of which prolongs the length of stay in the hospital. It is known that this syndrome develops as a result of endothelial dysfunction and activation of the systemic inflammatory response. In this connection, it is necessary to compare the clinical data and the results of instrumental research methods to assess the effect of chronic obstructive pulmonary disease on the course of post-pericardicotomy syndrome. The study revealed that chronic obstructive pulmonary disease is not a predictor of the development of PCTS, but complicates its course.
Stroke patients care by the Senegal-National Emergency Medical Services: retrospective study over 18 months
Authors: Diop-Sène Marième Soda , Cissé Ousmane , Ababacar Mbaye Khalifa , Diagne Rokhaya , Mbodji Ahmadou Bamba , Diagne Ngor Side , Sissoko Papis , Touré Kamadore , Ndiaye Moustapha , Diop Amadou Gallo
Published: May 2021

ntroduction: Stroke according to the WHO (World Health Organization) is a sudden deficit of focal brain function with no apparent cause other than a vascular cause. It is a major public health problem. It is the first cause of motor disability, second cause of cognitive disability and third cause of mortality in the world. Material and method: It is a retrospective and descriptive study of a period of 18 months (January 1, 2016 to October 30, 2017) conducted in the national Emergency Medical Services of Dakar (Senegal). According to our study criteria, 343 patients were collected. Results: The mean age of the patients was 64.2 years (extremes of 17 and 104 years). Men represented 54.22% (sex ratio M/W 1.8). Dakar represented the main provenance of our patients (79.30%). Hypertension was the main risk factor (50%). Acute headaches were the main warning sign (13.41%). An echocardiography was performed in 59 patients; complete tachyarrhythmia by atrial fibrillation represented 30% of the ECG. The CT-scan was performed for 201 patients (61% of ischemic stroke, 37.5% hemorrhagic and 1.5% of transient ischemic attack). The medevac represented 53.93%. Transportation was made essentially by the emergency medical services; home interventions were the most represented. The mean time for intervention by the emergency medical services was 134.71 minutes. Fann Hospital was the main host structure (45.49%). The care (of the emergency medical services) included, among others, intubation (4.8%), monitoring, oxygen therapy, urinary catheter and medical treatment. We noticed 20.40% of deaths in our series, due essentially to neurological complications. Conclusion: Stroke is a major public health problem. Difficulties are sometimes encountered in the care and the research of an appropriate host structure. The purpose of the pre-hospital care is to intervene as soon as possible while making a clinic diagnosis by performing forthwith a brain CT-scan in order to optimize the care and improve the prognostic of stroke patients.
Post-operative compressive pneumocephalus: A rare complication of lumbar spinal drainage
Authors: Lakhdar F , Benzagmout M , Chakour K , Chaoui ME
Published: May 2021

Compressive pneumocephalus is a rare condition, most often secondary to head trauma or surgery. We report post-operativecompressive pneumocephalus in a patient who underwent primary surgery for anterior clinoidmeningioma complicated by CSF leakage treated by lumbar spinal drainage. CT scanclearly demonstrates a compressive pneumocephaluswith the sign of the Mount Fuji. The patient was treated with definite bed rest and plenty of fluid replacement with good outcome. Compressive pneumocephalus is a serious, infrequent complication anda possible cause of postoperative worsening.Medical treatment combining highly inspired oxygen therapy and rehydration are sufficient to correct the condition.
Emerging highlights from novel human coronavirus and angiotensin-converting enzyme 2: promising way to target brain vascular diseases
Authors: Ambrosi Caroline Bozzetto
Published: May 2021

A specific metallopeptidase called angiotensin-converting enzyme 2 (ACE2) has been identified as the modulating receptor on the surface of the endothelium and other human cells infected by the new coronavirus causing Severe Acute Respiratory Syndrome (SARS-CoV-2) and Human Coronavirus Disease 2019 (COVID -19). This modulation of the expression of ACE2 in human cells may be responsible for the production of pro-inflammatory response with the development of the state of the systemic response of the inflammatory system, hypercoagulability/stasis also an increased risk of both ischemic and hemorrhagic strokes. Therefore, like ACE2, despite being present in almost all human organs, its expression is variable and probably dependent on epigenetic polymorphism, then this is still to be better understood. However, this highlights the importance to understand its pathogenesis and open the doors for the development of future treatment strategies aimed at various diseases related to ACE2, mainly cerebral vascular diseases, and perhaps COVID-19 itself.