bluuebunny/crossref_metadata_2025 huggingface dataset:
Planning-based security testing of web applications with attack grammars
Authors: Bozic Josip , Wotawa Franz
Published: March 2020

Web applications are deployed on machines around the globe and offer almost universal accessibility. These applications assure functional interconnectivity between different components on a 24/7 basis. One of the most important requirements is data confidentiality and secure authentication. However, implementation flaws and unfulfilled requirements often result in security leaks that malicious users eventually exploited. In this context, the application of different testing methods is of utmost importance in order to detect software defects during development and to prevent unauthorized access in advance. In this paper, we contribute to test automation for web applications. In particular, we focus on using planning for testing where we introduce underlying models covering attacks and their use in testing of web applications. The planning model offers a high degree of extendibility and configurability and as well overcomes limits of traditional graphical representations. New testing possibilities emerge that eventually lead to better vulnerability detection, therefore ensuring more secure web services and applications.
The rationale of using cerebral embolic protection devices during transcatheter aortic valve implantation
Authors: Simsek C. , Schölzel B. E. , den Heijer P. , Vos J. , Meuwissen M. , van den Branden B. , IJsselmuiden A. J. J.
Published: March 2020

Aortic valve stenosis is one of the most common valvular abnormalities, which can manifest as angina, syncope, dyspnoea and sudden cardiac death. Transcatheter aortic valve implantation (TAVI) has been introduced as an alternative to surgical valve replacement in patients with severe aortic valve stenosis, resulting in less morbidity, shorter time to recovery and similar mortality rates. Progress in this field has reduced complication rates. However, the incidence of peri-procedural stroke remains relatively high (around 4%). To fully utilise the potential of TAVI, cerebral embolic protection devices (CEPD) have been developed and introduced. In this position paper, we aim to summarise the available data on several CEPD.
Leaving the Shadow: A Configurational Approach to Explain Post-identification Outcomes of Shadow IT Systems
Authors: Fürstenau Daniel , Rothe Hannes , Sandner Matthias
Published: March 2020

With the advent of end-user and cloud computing, business users can implement information systems for work practices on their own – either from scratch or as extensions to existing systems. The resulting information systems, however, often remain hidden from managers and official IT units, and are therefore called “shadow IT systems”. When a shadow IT system is identified, the organization has to decide on the future of this system. The study uses a configurational perspective to explain outcomes of shadow IT system identification, as well as the mechanisms and contextual conditions which bring them about. For this purpose, 27 profiles of shadow IT systems were compiled by conducting 35 interviews with respondents from different positions and industries. The analysis gives insight into six distinct context-mechanism-outcome configurations explaining four outcomes that occur after shadow IT system identification, namely phase-out, replacement, continuing as IT-managed system, and continuing as business-managed system. These results contribute to the shadow IT literature and, more broadly, IS architecture and governance streams of the IS literature. They inform IT managers when these weigh decision options for identified shadow IT systems given different contextual conditions.
The effects of seawater and nanosilica on the performance of blended cements and composites
Authors: Sikora Pawel , Lootens Didier , Liard Maxime , Stephan Dietmar
Published: March 2020

This study investigates the effects of seawater and nanosilica (3% by weight of cement), on the fresh and hardened properties of cement pastes and mortars produced with two types of low heat cements: Portland pozzolana cement (CEM II) and blast furnace cement (CEM III). The heat of hydration, initial and final setting times, rheological properties, strength development, sorptivity and water accessible porosity of the cement pastes and mortars were determined. The data reveal that cement type has a significant effect on the reaction rate of cement with seawater and nanosilica (NS). Specimens produced with slag-blended cement exhibited a higher cement reaction rate and the composite produced exhibited better mechanical performance, as a result of the additional reaction of alumina rich phases in slag, with seawater. Replacement of freshwater with seawater contributes mostly to a significant improvement of early strength. However, in the case of slag-blended cement, 28 day strength also improved. The incorporation of NS results in additional acceleration of hydration processes, as well as to a decrease in cement setting time. In contrast, the addition of NS results in a noticeable increment in the yield-stress of pastes, with this effect being pronounced when NS is mixed along with seawater. Moreover, the use of seawater and NS has a beneficial effect on microstructure refinement, thus improving the transport properties of cement mortars. Overall, the study has showed that both seawater and NS can be successfully used to accelerate the hydration process of low heat blended cements and to improve the mechanical and transport properties of cement-based composites.
Dynkin game under g-expectation in continuous time
Authors: Wu Helin , Ren Yong , Hu Feng
Published: March 2020

In this paper, we investigate some kind of Dynkin game under g-expectation induced by backward stochastic differential equation (short for BSDE). The lower and upper value functions $$\underline{V}_t=ess\sup \nolimits _{\tau \in {\mathcal {T}_t}} ess\inf \nolimits _{\sigma \in {\mathcal {T}_t}}\mathcal {E}^g_t[R(\tau ,\sigma )]$$

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and $$\overline{V}_t=ess\inf \nolimits _{\sigma \in {\mathcal {T}_t}} ess\sup \nolimits _{\tau \in {\mathcal {T}_t}}\mathcal {E}^g_t[R(\tau ,\sigma )]$$

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are defined, respectively. Under some suitable assumptions, a pair of saddle points is obtained and the value function of Dynkin game $$V(t)=\underline{V}_t=\overline{V}_t$$

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follows. Furthermore, we also consider the constrained case of Dynkin game.
Visualization of the molten pool of the laser beam submerged arc hybrid welding process
Authors: Reisgen U. , Olschok S. , Engels O.
Published: March 2020

Submerged arc welding is currently the predominant industrial welding process for joining various steel grades in the plate thickness range of about 40 mm. A high energy input and the associated component distortion are unavoidable due to the high number of welding layers. By combining the conventional submerged arc welding process with the laser beam welding process to form a common hybrid welding process, this welding task can be mastered in only two welding layers by means of layer-counter-layer technology. This considerably reduces the welding time and thermally induced component distortion to a minimum due to the symmetrical energy input. A characteristic feature of a hybrid welding process is the formation of a common weld pool. In previous studies, the mixing of the molten pool has already been proven using chemical analysis methods. In the context of this paper, the shaping of the hybrid weld pool is also discussed. The molten material is expelled out of the joining zone by means of a gas pressure surge. Subsequently, a light section sensor was used to scan this area and produce a three-dimensional image from the formerly molten weld seam area. This shows that a single contiguous melt pool is produced. Finally, the first one-sided welds with full penetration and backing will be presented and discussed.
Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease
Authors: Meyer Fabian , Seibert Felix S. , Nienen Mikalai , Welzel Marius , Beisser Daniela , Bauer Frederic , Rohn Benjamin , Westhoff Timm H. , Stervbo Ulrik , Babel Nina
Published: March 2020

Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60 days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and significant expansion in the frequencies of CD25highCD127−Tregs in both groups. Phenotypic characterization suggests that polarization of naïve T cells towards Tregs is responsible for the observed expansion. In line with this, we observed a significant reduction of inflammatory marker CRP under propionate supplementation. Of interest, the observed anti-inflammatory surroundings did not affect the protective pathogen-specific immunity as demonstrated by the stable frequencies of effector/memory T cells specific for tetanus/diphtheria recall antigens. Collectively, our data suggest that dietary supplements with propionate have a beneficial effect on the elevated systemic inflammation of ESRD patients. The effect can be achieved through an expansion of circulating Tregs without affecting the protective pathogen-reactive immunity.
Influence of Carbide-Promoting Elements on the Microstructure of High-Silicon Ductile Iron
Authors: Riebisch M. , Pustal B. , Bührig-Polaczek A.
Published: March 2020

Because of its low cost, steel scrap is one of the most important raw materials for the production of ductile iron (DI). The amount of carbide-promoting elements in steel scrap, such as chromium, manganese, molybdenum, niobium and vanadium, is expected to increase in the future. Most of these elements have a negative impact on the microstructure and mechanical properties of DI. The solubility of carbide-promoting elements in solid solution-strengthened DI materials, standardized in DIN EN 1563:2011, is modified by the high silicon content. For these new materials, the tolerance limits for carbide-promoting elements and their mutual influence must be known to ensure a sustainable production process. To investigate the individual and combined impact of carbide-promoting elements on the carbide content in high-silicon ductile iron EN-GJS-500-14, experimental investigations and thermodynamic–kinetic microstructure simulations were carried out. Microstructure was characterized using metallographic analysis, and quantitative relations between chemical composition and microstructure were developed by means of regression analysis. Besides this quantitative analysis, it was found that the formation of grain boundary carbides can be detected via thermal analysis. Furthermore, experiments and simulations showed that vanadium promotes the formation of chunky graphite in high-silicon DI castings.
Universal decomposed Banach spaces
Authors: Banakh Taras , Garbulińska-Wȩgrzyn Joanna
Published: March 2020

Let$${\mathcal {B}}$$Bbe a class of finite-dimensional Banach spaces. A$${\mathcal {B}}$$B-decomposed Banach spaceis a Banach spaceXendowed with a family$${\mathcal {B}}_X\subset {\mathcal {B}}$$BX⊂Bof subspaces ofXsuch that each$$x\in X$$x∈Xcan be uniquely written as the sum of an unconditionally convergent series$$\sum _{B\in {\mathcal {B}}_X}x_B$$∑B∈BXxBfor some$$(x_B)_{B\in {\mathcal {B}}_X}\in \prod _{B\in {\mathcal {B}}_X}B$$(xB)B∈BX∈∏B∈BXB. For every$$B\in {\mathcal {B}}_X$$B∈BXlet$$\mathrm {pr}_B:X\rightarrow B$$prB:X→Bdenote the coordinate projection. Let$$C\subset [-1,1]$$C⊂[-1,1]be a closed convex set with$$C\cdot C\subset C$$C·C⊂C. TheC-decomposition constant$$K_C$$KCof a$${\mathcal {B}}$$B-decomposed Banach space$$(X,{\mathcal {B}}_X)$$(X,BX)is the smallest number$$K_C$$KCsuch that for every function$$\alpha :{\mathcal {F}}\rightarrow C$$α:F→Cfrom a finite subset$${\mathcal {F}}\subset {\mathcal {B}}_X$$F⊂BXthe operator$$T_\alpha =\sum _{B\in {\mathcal {F}}}\alpha (B)\cdot \mathrm {pr}_B$$Tα=∑B∈Fα(B)·prBhas norm$$\Vert T_\alpha \Vert \le K_C$$‖Tα‖≤KC. By$$\varvec{{\mathcal {B}}}_C$$BCwe denote the class of$${\mathcal {B}}$$B-decomposed Banach spaces withC-decomposition constant$$K_C\le 1$$KC≤1. Using the technique of Fraïssé theory, we construct a rational$${\mathcal {B}}$$B-decomposed Banach space$$\mathbb {U}_C\in \varvec{{\mathcal {B}}}_C$$UC∈BCwhich contains an almost isometric copy of each$${\mathcal {B}}$$B-decomposed Banach space$$X\in \varvec{{\mathcal {B}}}_C$$X∈BC. If$${\mathcal {B}}$$Bis the class of all 1-dimensional (resp. finite-dimensional) Banach spaces, then$$\mathbb {U}_{C}$$UCis isomorphic to the complementably universal Banach space for the class of Banach spaces with an unconditional (f.d.) basis, constructed by Pełczyński (and Wojtaszczyk).
Sexual Interest in Children Among Women in Two Nonclinical and Nonrepresentative Online Samples
Authors: Tozdan Safiye , Dekker Arne , Neutze Janina , Santtila Pekka , Briken Peer
Published: March 2020

Introduction

Regarding women, little research is available about the prevalence of sexual interest in children (SIC), especially in nonclinical samples.

Aim

The present study aimed to investigate the extent to which adult women from 2 nonclinical and nonrepresentative samples indicate sexual interest in prepubescent and/or pubescent children.

Methods

Participants took part in an online survey either via general websites or via websites directed toward individuals with a SIC.

Main Outcome Measures

The self-report survey included questions about the use of online abuse material including children and teenagers as well as about sexual fantasies involving prepubescent and pubescent children. Both measures were included as main outcome measures.

Results

Results showed that few women reported having used online abuse material including children (total sample: n = 7 [0.8%], general websites: n = 3 [0.4%], SIC websites: n = 4 [9.5%]) or teenagers (total sample: n = 44 [5.0%], general websites: n = 37 [4.4%], SIC websites: n = 7 [16.7%]). Results further revealed that some women reported sexual fantasies involving prepubescent (total sample: n = 98 [7.0%], general websites: n = 92 [6.8%], SIC websites: n = 6 [11.1%]) or pubescent children (total sample: n = 136 [9.6%], general websites: n = 129 [9.5%], SIC websites: n = 7 [13.0%]).

Conclusions

The samples included are nonrepresentative and therefore not generalizable to the female population. Nevertheless, they strongly suggest that SIC is a phenomenon also found in women. We therefore recommend professionals in the field of sexual medicine to increase their attention and engagement for women with SIC. Based on the present results, the development of preventive treatment services specifically tailored to women with a SIC has to be strongly encouraged in the near future.

Tozdan S, Dekker A, Neutze J, et al. Sexual Interest in Children Among Women in Two Nonclinical and Nonrepresentative Online Samples. Sex Med 2020;8:251–264.
The enigma of gastroesophageal reflux disease among convalescing infants in the NICU
Authors: Badran Eman F. , Jadcherla Sudarshan
Published: March 2020

Gastroesophageal reflux (GER) can be a normal physiological process, or can be bothersome, when aerodigestive consequences are associated; the latter is often interpreted as GER disease (GERD). However, the distinction between these two entities remains an enigma among infants surviving after neonatal intensive care (NICU) care. Symptoms related to GERD are heterogeneous, and are often managed with changes in diet, feeding methods, and acid suppressive therapy. However, none of these approaches have been well-tested in neonates; hence practice variation is very high world-wide. In this paper, we explain the variation in diagnosis, pathophysiology of the clinical presentation, and highlight approaches to diagnosis and management.
An assessment of racial differences in epidemiological, clinical and psychosocial factors among head and neck cancer patients at the time of surgery
Authors: Kompelli Anvesh , Cartmell Kathleen B. , Sterba Katherine R. , Alberg Anthony J. , Xiao Christopher C. , Sood Amit J. , Garrett‐Mayer Elizabeth , White‐Gilbertson Shai J. , Rosenzweig Steven A. , Day Terry A.
Published: March 2020

Objective

Racial disparities have been well characterized and African American (AA) patients have 30% lower 5‐year survival rates than European Americans (EAs) for head and neck squamous carcinoma (HNSCC). This poorer survival can be attributed to a myriad of different factors. The purpose of this study was to characterize AA‐EA similarities and differences in sociodemographic, lifestyle, clinical, and psychosocial characteristics in HNSCC patients near the time of surgery.

Methods

Setting: Single tertiary care center. Participants: Thirty‐nine newly diagnosed, untreated HNSCC patients (n = 24 EAs,n = 15 AAs) who were to undergo surgery were recruited. Study Design: Cross‐sectional study Sociodemographic, lifestyle factors, and disease factors (cancer site, AJCC clinical and pathologic stage, and HPV status)were assessed. Risk factors, leisure time, quality of life and social support were also assessed using validated questionnaires. Exposures: EA and AA patients were similar in the majority of sociodemographic factors assessed. AAs had a higher trend toward pathologically later stage disease compared to EAs and significantly increased time to treatment.

Results

EA and AA patients were similar in the majority of sociodemographic factors assessed. AAs had a higher trend toward pathologically later stage disease compared to EAs. AAs also had significantly increased time to treatment (P = 0.05). The majority of AA patients (62%) had later stage pathologic disease. AA were less likely to complete high school or college (P = 0.01) than their EA counterparts. Additionally, AAs were more likely to report having a gap in health insurance during the past decade (37% vs. 15%).

Conclusions

This preliminary study demonstrates a similar profile of demographics, clinical and psychosocial characteristics preoperatively for AAs and EAs. Key differences were AAs tending to have later pathologic stage disease, educational status, delays in treatment initiation, and gaps in health insurance.
Social Media Use in Emergency Response to Natural Disasters: A Systematic Review With a Public Health Perspective
Authors: Muniz-Rodriguez Kamalich , Ofori Sylvia K. , Bayliss Lauren C. , Schwind Jessica S. , Diallo Kadiatou , Liu Manyun , Yin Jingjing , Chowell Gerardo , Fung Isaac Chun-Hai
Published: March 2020

Social media research during natural disasters has been presented as a tool to guide response and relief efforts in the disciplines of geography and computer sciences. This systematic review highlights the public health implications of social media use in the response phase of the emergency, assessing (1) how social media can improve the dissemination of emergency warning and response information during and after a natural disaster, and (2) how social media can help identify physical, medical, functional, and emotional needs after a natural disaster. We surveyed the literature using 3 databases and included 44 research articles. We found that analyses of social media data were performed using a wide range of spatiotemporal scales. Social media platforms were identified as broadcasting tools presenting an opportunity for public health agencies to share emergency warnings. Social media was used as a tool to identify areas in need of relief operations or medical assistance by using self-reported location, with map development as a common method to visualize data. In retrospective analyses, social media analysis showed promise as an opportunity to reduce the time of response and to identify the individuals’ location. Further research for misinformation and rumor control using social media is needed.
Does Trust in Government Increase Support for Redistribution? Evidence from Randomized Survey Experiments
Authors: PEYTON KYLE
Published: March 2020

Why have decades of high and rising inequality in the United States not increased public support for redistribution? An established theory in political science holds that Americans’ distrust of government decreases their support for redistribution, but empirical support draws primarily on regression analyses of national surveys. I discuss the untestable assumptions required for identification with regression modeling and propose an alternative design that uses randomized experiments about political corruption to identify the effect of trust in government on support for redistribution under weaker assumptions. I apply this to three survey experiments and estimate the effects that large, experimentally induced increases in political trust have on support for redistribution. Contrary to theoretical predictions, estimated effects are substantively negligible, statistically indistinguishable from zero, and comparable to estimates from two placebo experiments. I discuss implications for theory building about causes of support for redistribution in an era of rising inequality and eroding confidence in government.
Clustering of hypertension, diabetes and overweight/obesity according to socioeconomic status among Bangladeshi adults
Authors: Kibria Gulam Muhammed Al , Hashan Mohammad Rashidul , Hossain Md Mahbub , Zaman Sojib Bin , Stennett Christina A.
Published: March 2020

The prevalences of hypertension, diabetes and overweight/obesity are increasing in most developing countries, including Bangladesh. Although earlier studies have investigated the factors associated with these three conditions, little is known about whether socioeconomic status is associated with their co-existence. This cross-sectional study analysed data from the 2011 Bangladesh Demographic and Health Survey. An individual was considered hypertensive, diabetic and overweight/obese if their systolic/diastolic blood pressure, fasting plasma glucose concentration, and body mass index were ≥130/80 mmHg, ≥7 mmol/l and ≥23 kg/m2, respectively. Furthermore, individuals who reported taking anti-hypertensive and anti-diabetic drugs were also considered as hypertensive and diabetic, respectively. Two socioeconomic variables were investigated: education level and household wealth quintile. Descriptive analyses and multilevel logistic regression were conducted. Among the 7932 respondents (50.5% female) aged ≥35 years, the prevalences of hypertension, diabetes, overweight/obesity, any one condition and the co-existence of the three conditions were 48.0%, 11.0%, 25.3%, 60.9% and 3.6%, respectively. In adjusted analysis, individuals with secondary (adjusted odds ratio [AOR]: 1.8, 95% confidence interval [CI]: 1.2–2.8) and college or above (AOR: 3.6; 95% CI: 2.2–5.7) education levels had higher odds of the co-existence of all three conditions compared with those with no formal education. Similarly, compared with the poorest wealth quintile, the richer (AOR: 4.6; 95% CI: 2.2–9.4) and richest (AOR: 11.8; 95% CI: 5.8–24.1) wealth quintiles had higher odds of co-existence of these three conditions. Education and wealth quintile also showed significant relationships with each of the three conditions separately. In conclusion, in Bangladesh, hypertension, diabetes and overweight/obesity are associated with indicators of higher socioeconomic status. These findings highlight the importance of developing healthy lifestyle interventions (e.g. physical exercise and dietary modification) targeting individuals of higher socioeconomic status to minimize the burden of these non-communicable diseases.
Publicizing Arbitrage
Authors: Kahraman Bige
Published: March 2020

How does greater public disclosure of arbitrage activity and informed trading affect price efficiency? To answer this, we exploit rule amendments in U.S. securities markets, which impose a higher frequency of public disclosure of short positions. Higher public disclosure can hurt the production of information and deteriorate efficiency, or it can be beneficial by mitigating the limits to arbitrage and diffusing arbitrageurs’ information faster. With more frequent disclosure, information encapsulated within short interest is incorporated into prices faster, improving price efficiency. We find important reductions in short sellers’ horizon risk and increases in short sales with the rule amendments.
Generational differences in loneliness and its psychological and sociodemographic predictors: an exploratory and confirmatory machine learning study
Authors: Altschul Drew , Iveson Matthew , Deary Ian J.
Published: March 2020

Background

Loneliness is a growing public health issue in the developed world. Among older adults, loneliness is a particular challenge, as the older segment of the population is growing and loneliness is comorbid with many mental as well as physical health issues. Comorbidity and common cause factors make identifying the antecedents of loneliness difficult, however, contemporary machine learning techniques are positioned to tackle this problem.

Methods

This study analyzed four cohorts of older individuals, split into two age groups – 45–69 and 70–79 – to examine which common psychological and sociodemographic are associated with loneliness at different ages. Gradient boosted modeling, a machine learning technique, and regression models were used to identify and replicate associations with loneliness.

Results

In all cohorts, higher emotional stability was associated with lower loneliness. In the older group, social circumstances such as living alone were also associated with higher loneliness. In the younger group, extraversion's association with lower loneliness was the only other confirmed relationship.

Conclusions

Different individual and social factors might underlie loneliness differences in distinct age groups. Machine learning methods have the potential to unveil novel associations between psychological and social variables, particularly interactions, and mental health outcomes.
Matching biodiversity and ecology ontologies: challenges and evaluation results
Authors: Karam Naouel , Khiat Abderrahmane , Algergawy Alsayed , Sattler Melanie , Weiland Claus , Schmidt Marco
Published: March 2020

Biodiversity research studies the variability and diversity of organisms, including variability within and between species with particular focus on the functional diversity of traits and their relationship to environment. Managing biodiversity data implies dealing with its heterogeneous nature using semantics and tailored ontologies. These are themselves differently conceived, and combining them in semantically enabled applications necessitates an effective alignment between their concepts. This paper describes the ontology matching of biodiversity- and ecology-related ontologies. We illustrate diverse challenges introduced by this kind of ontologies to ontology matching in general. Real use cases requiring pairwise alignments between environment and trait ontologies are introduced. We describe our experience creating a new track at the Ontology Alignment Evaluation Initiative designed for this specific domain and report on the results obtained by state-of-the-art participating systems. The biodiversity and ecology use case turns out to be a strong one for ontology matching, introducing new interesting challenges. Even if most of the matching systems perform relatively well in the proposed matching tasks, there is still room for improvement. We highlight possible directions in that matter and elaborate on our plan to further progress with the track.
The semantics of Englishout-prefixation: a corpus-based investigation
Authors: KOTOWSKI SVEN
Published: March 2020

The verbal prefixout- in its scalar-comparative sense is among the most productive English locative prefixes. Although several authors make use of the construction as a test environment for verb classification, few studies have looked at its semantics in any depth. Moreover, previous work on this prefix relies on fairly small databases or self-generated data, and no reliable corpus-based investigations are available, calling into question the usefulness of present semantic analyses and the application of the construction as a test environment.

This study aims at remedying these shortcomings via presenting a database culled mostly from COCA and iWeb. Based on the analysis of the wide range of attestations in the database it is shown that existing generalizations and previous semantic analyses are wrong and that particular restrictions proposed in the literature are not borne out by the data. Several claims, including core features of the formalizations offered in the literature, have to be discarded. Furthermore, alleged base-restrictions on the inputout- allows are shown to be far too restrictive. This holds for verbal as well as adjectival and nominal bases. It is shown that approaches that deny the existence of category-changing prefixes are misguided.

Overall, the construction is more flexible regarding possible interpretations and more promiscuous with respect to possible bases than previously thought. At the same time, the system is not unrestricted. Generalizing over the data, this article lays out the requirements and specific challenges any full formal account ofout- will have to match.
QUILLEN EQUIVALENT MODELS FOR THE DERIVED CATEGORY OF FLATS AND THE RESOLUTION PROPERTY
Authors: ESTRADA SERGIO , SLÁVIK ALEXANDER
Published: March 2020

We investigate the assumptions under which a subclass of flat quasicoherent sheaves on a quasicompact and semiseparated scheme allows us to ‘mock’ the homotopy category of projective modules. Our methods are based on module-theoretic properties of the subclass of flat modules involved as well as their behaviour with respect to Zariski localizations. As a consequence we get that, for such schemes, the derived category of flat quasicoherent sheaves is equivalent to the derived category of very flat quasicoherent sheaves. If, in addition, the scheme satisfies the resolution property then both derived categories are equivalent to the derived category of infinite-dimensional vector bundles. The equivalences are inferred from a Quillen equivalence between the corresponding models.
Reading the Musical Surreal through Poulenc's Fifth Relations
Authors: DONALDSON JAMES
Published: March 2020

This article develops a method of understanding concepts from the Parisian Surrealist movement in music using Poulenc's treatment of cadences and fifth relations as a case study. Although music was rejected by the group's figurehead André Breton as ‘the most profoundly confusing’ of all arts, many composers were keenly involved in Surrealist circles. Notably, Poulenc's acquaintance with major figures led him to set much of their literary work. But his engagement with their aesthetic principles extends deep into the musical form. After assessing Poulenc's flirtation with the movement's ideas, I ally William Caplin's codification of the cadence to the Surrealistobjet trouvé. Combining Robert Hatten's musical ‘markedness’ and literary theorist Willard Bohn's model of Surrealism in art and literature, I explore how Poulenc's music engages with the Surrealist treatment of objects, automatism, and Apollinaire's ‘fantôme véritable’.
Evaluation of Paleocene‐Eocene Thermal Maximum Carbon Isotope Record Completeness—An Illustration of the Potential of Dynamic Time Warping in Aligning Paleo‐Proxy Records
Authors: Ajayi Seyi , Kump Lee R. , Ridgwell Andy , Kirtland Turner Sandra , Hay Carling C. , Bralower Timothy J.
Published: March 2020

Variations in sedimentation rate, bioturbation, winnowing, and dissolution modify the deep‐sea sedimentary record, complicating the apparent relationship between stratigraphic depth and time of a geochemical proxy record and confounding the extraction of a clear picture of past climates and environments. Dynamic time warping (DTW) is used to align time series with similar patterns. Here we explore the use of DTW to identify gaps in proxy records of the Paleocene‐Eocene thermal maximum (PETM), aligning bulk sediment carbonate isotope records (δ13C) from various deep‐sea sediment core sections spanning the event. Alignment of PETM δ13C records from the Walvis Ridge, South Atlantic transect of ODP Leg 208 (Sites 1262, 1263, and 1265) was similar to previously published manually established alignments and consistent with the expectation that shallower sites have more complete records. The δ13C record from a Southern Ocean site (Maud Rise; ODP Site 690) was then aligned to ODP Site 1263, the most complete Walvis Ridge site. This alignment identifies a gap in Site 690, indicating that peak excursion δ13C values were not recorded. We conclude that DTW provides an objective way to align climate proxy records and rectify data loss associated with unconformities and other types of distortions, leading to a more complete understanding of the geologic record of past episodes of biotic and environmental change.
Coupled Evolution of Deformation, Pore Fluid Pressure, and Fluid Flow in Shallow Subduction Forearcs
Authors: Sun Tianhaozhe , Ellis Susan , Saffer Demian
Published: March 2020

Deformation and fluid flow in subduction zone forearcs are dynamically coupled, but our quantitative understanding of their coupling is incomplete. In this work, we investigate the hydrological and mechanical coupling in shallow forearcs, using a Lagrangian‐Eulerian finite element model that incorporates constitutive and transport properties of sediments and faults constrained by laboratory and field measurements. Wide‐ranging observations show that sediment thickness and composition, plate convergence rate, basement strength and roughness, and subducting slab dip angle vary between subduction zones. We therefore systematically study their effects on forearc stress and pore fluid pressure states, consolidation and dewatering patterns, and margin morphology. Our models, with the incorporation of a simple description of permeability enhancement along fault damage zones, yield a range of fault permeability (10−13–10−17 m2) consistent with previous estimates and describe the important role of upper plate splay faults in causing heterogeneous dewatering and consolidation patterns and in modulating effective normal stress on the plate interface. Spatial variations in tectonic loading and sediment consolidation can also be caused by subducting basement roughness such as a horst‐and‐graben structure. For typically observed relief and spacing, our models predict locally enhanced porosity reduction by up to 50% at the downdip edge of the horsts and anomalously high sediment porosity above the geometrical highs. At the margin scale, our results demonstrate that sediment permeability and thickness are dominant controls on fluid overpressure, sediment compaction, and megathrust strength. Rough and frictionally strong megathrusts produce similar effects in driving high wedge tapers.
Groundwater Management in the Borderlands of Mexico and Texas: The Beauty of the Unknown, the Negligence of the Present, and the Way Forward
Authors: Sanchez Rosario , Eckstein Gabriel
Published: March 2020

Over the last decade, transboundary aquifers traversing the Mexico‐Texas border have generated growing interest of federal institutions on the Mexico side and state and federal institutions on the Texas side. Notwithstanding this, binational efforts to understand, assess, and manage shared groundwater resources remain limited and politically sensitive. On the Mexico side, long‐standing centralized groundwater governance structures have created institutional barriers at the local level to the expansion of knowledge and cooperation over these transboundary resources. On the Texas side, property rights related to groundwater resources limit the scope of options available for cooperative management of cross‐border aquifers. This paper examines stakeholders' perspectives on the borderland between Mexico and Texas through 44 surveys and personal interviews. Findings show that stakeholders appear to support a binational groundwater agreement as a means for assuring the sound long‐term management of transboundary groundwater resources in the border region; however, the majority of stakeholders also suggest that short‐term local or regional arrangements may be preferable over binational agreements as local/regional approaches may be more achievable or realistic. Second, participants identified leadership and individual personalities as key factors for success at the local level but noted that such influence had limited sustainability and limited regional‐systemic effects. Third, the stakeholders indicated that water quality, rather than water quantity, is the main driver of transboundary cooperation efforts in the region. Fourth, participants suggested that failures and successes in groundwater cooperation efforts are based more on fear and political lobbying than on understanding of scientific facts.
Improved Understanding of the Link Between Catchment‐Scale Vegetation Accessible Storage and Satellite‐Derived Soil Water Index
Authors: Bouaziz Laurène J. E. , Steele‐Dunne Susan C. , Schellekens Jaap , Weerts Albrecht H. , Stam Jasper , Sprokkereef Eric , Winsemius Hessel H. C. , Savenije Hubert H. G. , Hrachowitz Markus
Published: March 2020

The spatiotemporal dynamics of water volumes stored in the unsaturated root zone are a key control on the response of terrestrial hydrological systems. Robust, catchment‐scale root‐zone soil moisture estimates are thus critical for reliable predictions of river flow, groundwater recharge, or evaporation. Satellites provide estimates of near‐surface soil moisture that can be used to approximate the moisture content in the entire unsaturated root zone through the Soil Water Index (SWI). The characteristic time length (T, in days), as only parameter in the SWI approach, characterizes the temporal variability of soil moisture. The factors controlling T are typically assumed to be related to soil properties and climate; however, no clear link has so far been established. In this study, we hypothesize that optimal T values (Topt) are linked to the interplay of precipitation and evaporation during dry periods, thus to catchment‐scale vegetation accessible water storage capacities in the unsaturated root zone. We identify Topt by matching modeled time series of root‐zone soil moisture from a calibrated process‐based hydrological model to SWI from several satellite‐based near‐surface soil moisture products in 16 contrasting catchments in the Meuse river basin. Topt values are strongly and positively correlated with vegetation accessible water volumes that can be stored in the root zone, here estimated for each study catchment both as model calibration parameter and from a water‐balance approach. Differences in Topt across catchments are also explained by land cover (% agriculture), soil texture (% silt), and runoff signatures (flashiness index).
From the Ground to Space: Using Solar‐Induced Chlorophyll Fluorescence to Estimate Crop Productivity
Authors: He Liyin , Magney Troy , Dutta Debsunder , Yin Yi , Köhler Philipp , Grossmann Katja , Stutz Jochen , Dold Christian , Hatfield Jerry , Guan Kaiyu , Peng Bin , Frankenberg Christian
Published: March 2020

Timely and accurate monitoring of crops is essential for food security. Here, we examine how well solar‐induced chlorophyll fluorescence (SIF) can inform crop productivity across the United States. Based on tower‐level observations and process‐based modeling, we find highly linear gross primary production (GPP):SIF relationships for C4 crops, while C3 crops show some saturation of GPP at high light when SIF continues to increase. C4 crops yield higher GPP:SIF ratios (30–50%) primarily because SIF is most sensitive to the light reactions (does not account for photorespiration). Scaling to the satellite, we compare SIF from the TROPOspheric Monitoring Instrument (TROPOMI) against tower‐derived GPP and county‐level crop statistics. Temporally, TROPOMI SIF strongly agrees with GPP observations upscaled across a corn and soybean dominated cropland (R2 = 0.89). Spatially, county‐level TROPOMI SIF correlates with crop productivity (R2 = 0.72; 0.86 when accounting for planted area and C3/C4 contributions), highlighting the potential of SIF for reliable crop monitoring.
Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making
Authors: Chen Si-Ye , Yang Yong , Qi Shu-Nan , Wang Ying , Hu Chen , He Xia , Zhang Li-Ling , Wu Gang , Qu Bao-Lin , Qian Li-Ting , Hou Xiao-Rong , Zhang Fu-Quan , Qiao Xue-Ying , Wang Hua , Li Gao-Feng , Zhang Yu-Jing , Zhu Yuan , Cao Jian-Zhong , Lan Sheng-Min , Wu Jun-Xin , Wu Tao , Zhu Su-Yu , Shi Mei , Xu Li-Ming , Yuan Zhi-Yong , Yahalom Joachim , Tsang Richard , Song Yu-Qin , Zhu Jun , Su Hang , Li Ye-Xiong
Published: March 2020

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated with anthracycline-based chemotherapy, we propose an easily used nomogram-revised risk index (NRI), validated it and compared with Ann Arbor staging, the International Prognostic Index (IPI), Korean Prognostic Index (KPI), and prognostic index of natural killer lymphoma (PINK) for overall survival (OS) prediction by examining calibration, discrimination, and decision curve analysis in a validation cohort of 1582 patients primarily treated with non-anthracycline-based chemotherapy. The calibration of the NRI showed satisfactory for predicting 3- and 5-year OS in the validation cohort. The Harrell’s C-index and integrated Brier score (IBS) of the NRI for OS prediction demonstrated a better performance than that of the Ann Arbor staging system, IPI, KPI, and PINK. Decision curve analysis of the NRI also showed a superior outcome. The NRI is a promising tool for stratifying patients with ENKTCL into risk groups for designing clinical trials and for selecting appropriate individualized treatment.
Direct molecular-level near-field plasmon and temperature assessment in a single plasmonic hotspot
Authors: Richard-Lacroix Marie , Deckert Volker
Published: March 2020

Tip-enhanced Raman spectroscopy (TERS) is currently widely recognized as an essential but still emergent technique for exploring the nanoscale. However, our lack of comprehension of crucial parameters still limits its potential as a user-friendly analytical tool. The tip’s surface plasmon resonance, heating due to near-field temperature rise, and spatial resolution are undoubtedly three challenging experimental parameters to unravel. However, they are also the most fundamentally relevant parameters to explore, because they ultimately influence the state of the investigated molecule and consequently the probed signal. Here we propose a straightforward and purely experimental method to access quantitative information of the plasmon resonance and near-field temperature experienced exclusively by the molecules directly contributing to the TERS signal. The detailed near-field optical response, both at the molecular level and as a function of time, is evaluated using standard TERS experimental equipment by simultaneously probing the Stokes and anti-Stokes spectral intensities. Self-assembled 16-mercaptohexadodecanoic acid monolayers covalently bond to an ultra-flat gold surface were used as a demonstrator. Observation of blinking lines in the spectra also provides crucial information on the lateral resolution and indication of atomic-scale thermally induced morphological changes of the tip during the experiment. This study provides access to unprecedented molecular-level information on physical parameters that crucially affect experiments under TERS conditions. The study thereby improves the usability of TERS in day-to-day operation. The obtained information is of central importance for any experimental plasmonic investigation and for the application of TERS in the field of nanoscale thermometry.
Carbon monoxide: a critical physiological regulator sensitive to light
Authors: Oren Dan A. , Sit Dorothy K. , Goudarzi Sohrab H. , Wisner Katherine L.
Published: March 2020

The mechanism by which humans absorb therapeutic light in winter seasonal and nonseasonal depression is unknown. Bright-light-induced release and generation of blood-borne gasotransmitters such as carbon monoxide (CO) may be one mechanism. Here, 24 healthy female volunteers had peripheral blood samples drawn. Samples were collected in a dimly lit room and protected from light exposure. Samples were analyzed for CO concentrations by gas chromatography after 2 h of continuous exposure to darkness vs. bright white light. In a similar confirmatory study, 11 additional volunteers had samples analyzed for CO concentrations after 2 h of continuous exposure to gentle rocking in darkness vs. in bright white light. In the first study, light-unexposed peripheral blood had a mean CO concentration of 1.8 ± 0.4 SD ppm/g. Identically treated samples with 2 h of rocking and exposure to bright white light at illuminance 10,000 lux had a mean CO of 3.6 ± 1.2 ppm/g (p < 0.0001). Post hoc analysis of that study showed that time of day was significantly inversely associated with increase in CO concentration under bright light vs. dark (p < 0.04). In a smaller confirmatory study of 11 healthy female volunteers, after 2 h of rocking, light-unexposed peripheral blood had a mean CO of 1.4 ± 0.5 SD ppm/g. Identically treated blood samples with 2 h of exposure to bright white light at illuminance 10,000 lux had a mean CO of 2.8 ± 1.7 ppm/g (p < 0.02). In conclusion, bright-light exposure robustly increases human blood CO in vitro. This supports the putative role of CO as a physiological regulator of circadian rhythms and light’s antidepressant effects. This human evidence replicates earlier data from a preclinical in vivo model. This effect may be stronger in the morning than in the afternoon.
Once- versus twice-weekly carfilzomib in relapsed and refractory multiple myeloma by select patient characteristics: phase 3 A.R.R.O.W. study subgroup analysis
Authors: Dimopoulos Meletios A. , Niesvizky Ruben , Weisel Katja , Siegel David S. , Hajek Roman , Mateos María-Victoria , Cavo Michele , Huang Mei , Zahlten-Kumeli Anita , Moreau Philippe
Published: March 2020

The phase 3 A.R.R.O.W. study demonstrated that treatment with once-weekly carfilzomib (70 mg/m2) and dexamethasone (once-weekly Kd70 mg/m2) improved progression-free survival compared with twice-weekly carfilzomib (27 mg/m2) and dexamethasone (twice-weekly Kd27 mg/m2) in patients with relapsed and refractory multiple myeloma (RRMM; median, 11.2 versus 7.6 months; hazard ratio [HR] = 0.69; 95% confidence interval, 0.54–0.88; P = 0.0029). Once-weekly dosing also improved response rates and depth of response. We performed a subgroup analysis from A.R.R.O.W. according to age (<65, 65–74, or ≥75 years), renal function (creatinine clearance <50, ≥50–<80, or ≥80 mL/min), number of prior therapies (2 or 3), and bortezomib-refractory status (yes or no). Compared with twice-weekly Kd27 mg/m2, once-weekly Kd70 mg/m2 reduced the risk of progression or death (HR = 0.60–0.85) and increased overall response rates in nearly all the examined subgroups, consistent with reports in the overall A.R.R.O.W. population. The safety profiles of once-weekly Kd70 mg/m2 across subgroups were also generally consistent with those in the overall population. Findings from this subgroup analysis generally demonstrate a favorable benefit–risk profile of once-weekly Kd70 mg/m2, further supporting once-weekly carfilzomib dosing as an appropriate treatment option for patients with RRMM, regardless of baseline patient and disease characteristics.