bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategies to reduce delays in delivering mechanical thrombectomy for acute ischaemic stroke – an umbrella review
Authors: Ameen D. , Dewey H. M. , Khalil H.
Published: June 2024

Background

Mechanical thrombectomy is a time-sensitive treatment, with rapid initiation and reduced delays being associated with better patient outcomes. Several systematic reviews reported on various interventions to address delays. Hence, we performed an umbrella review of systematic reviews to summarise the current evidence.

Methods

Medline, Embase, Cochrane Library and JBI were searched for published systematic reviews. Systematic Reviews that detailed outcomes related to time-to-thrombectomy or functional independence were included. Methodological quality was assessed using the JBI critical appraisal tool by two independent reviewers.

Results

A total of 17 systematic reviews were included in the review. These were all assessed as high-quality reviews. A total of 13 reviews reported on functional outcomes, and 12 reviews reported on time-to-thrombectomy outcomes. Various interventions were identified as beneficial. The most frequently reported beneficial interventions that improved functional and time-related outcomes included: direct-to-angio-suite and using a mothership model (compared to drip-and-ship). Only a few studies investigated other strategies including other pre-hospital and teamwork strategies.

Conclusion

Overall, there were various strategies that can be used to reduce delays in the delivery of mechanical thrombectomy with different effectiveness. The mothership model appears to be superior to the drip-and-ship model in reducing delays and improving functional outcomes. Additionally, the direct-to-angiosuite approach appears to be beneficial, but further research is required for broader implementation of this approach and to determine which groups of patients would benefit the most.
Causal relationship of interferon-γ and interleukin-18 upstream of intervertebral disc degeneration pathogenesis: a two-sample Mendelian randomization study
Authors: Gao Fang , Deng Chen , Wang Zhiqiang , Wang Beiyang , Lv Junqiao , Sun Lin
Published: June 2024

Introduction

Intervertebral disc degeneration (IVDD) is a complex disease caused by genetic and environmental factors, but its pathogenesis is still unclear. Although studies of inflammatory cytokines have been used in recent years to unravel the biological mechanisms of a variety of diseases, such analyses have not yet been applied to IVDD. Therefore, we used a Mendelian Randomization approach to explore the potential mechanisms underlying the pathogenesis of IVDD.

Methods

We obtained GWAS data from publicly available databases for inflammatory cytokines and IVDD, respectively, and explored the causal relationship between individual inflammatory cytokines and IVDD using instrumental variable (IV) analysis. We primarily used IVW methods to assess causality, while sensitivity, heterogeneity and multidirectionality analyses were performed for positive results (p < 0.05). All analyses were performed using R software.

Results

In our study, we performed a two-sample MR analysis of 41 inflammatory cytokines to identify metabolites causally associated with IVDD. Ultimately, 2 serum metabolites associated with IVDD were identified (pval<0.05), IFN-γ and IL-18. sensitivity, heterogeneity, and Pleiotropy test analyses were performed for all results.

Conclusion

Our study identified a causal relationship between IFN-γ and IL-18 and IVDD. It is valuable for the monitoring and prevention of IVDD and the exploration of targeted drugs. However, more evidence is needed to validate our study.
Association between sarcopenia and sleep disorders: a cross-sectional population based study
Authors: Liu Kepeng , Luo Jinhui , Chen Yong , Li Binfei , Tian Ye , Wang Xianxue , Liao Xiaozu
Published: June 2024

Objective

Sleep disorders is a worldwide public health problem. We sought to examine the association between sarcopenia, a decline in skeletal muscle mass and function, and sleep disorders within the adult demographic of the United States during the period spanning 2011 to 2018.

Methods

Diagnosis of sarcopenia and sleep disorders was ascertained through appropriate calculations and a structured questionnaire. The primary correlation analysis was conducted using a weighted multivariate logistic regression model. Furthermore, to confirm the presence of a potential non-linear association between sarcopenia and sleep disorders, additional analyses were performed using multivariate logistic regression and restricted cubic spline (RCS) regression with dose-response curve analysis. Subgroup analyses were also conducted to explore the influence of relevant socio-demographic factors and other covariates.

Results

The final analysis encompassed 5,616 participants. Model 4, inclusive of all pertinent covariates, revealed a positive correlation between sarcopenia and sleep disorders, yielding an odds ratio (OR) of 1.732 (95% CI: 1.182–2.547; P = 0.002). Further analysis, utilizing the restricted cubic spline model, indicated a decreasing trend in sleep disorders as sarcopenia indices rose. Stratified analyses across diverse variables underscored the significant impact of sarcopenia on sleep disorders prevalence in several subgroups. Specifically, males, individuals aged 40 and above, non-Hispanic whites, those with high school education or equivalent, unmarried individuals, obese individuals (BMI ≥ 30), alcohol drinkers, former smokers, diabetics, and those engaging in less rigorous recreational activities exhibited a more pronounced association between sarcopenia and sleep disorders. The incidence of sleep disorders exhibited an upward trend as the incidence of sarcopenia declined among study participants.

Conclusions

In summary, our study provides evidence of an association between sarcopenia and the prevalence of sleep disorders, with a negative correlation observed between the sarcopenia index and the odds ratio of sleep disorders. These findings suggest that maintaining optimal muscle mass may have a beneficial impact on sleep-related issues. In terms of exploring the mechanisms underlying the relationship between sarcopenia and sleep disorders, more in-depth research is warranted to ascertain the definitive causal relationship.
Elucidating the role of angiogenesis-related genes in colorectal cancer: a multi-omics analysis
Authors: Wei Hao-tang , Xie Li-ye , Liu Yong-gang , Deng Ya , Chen Feng , Lv Feng , Tang Li-ping , Hu Bang-li
Published: June 2024

Background

Angiogenesis plays a pivotal role in colorectal cancer (CRC), yet its underlying mechanisms demand further exploration. This study aimed to elucidate the significance of angiogenesis-related genes (ARGs) in CRC through comprehensive multi-omics analysis.

Methods

CRC patients were categorized according to ARGs expression to form angiogenesis-related clusters (ARCs). We investigated the correlation between ARCs and patient survival, clinical features, consensus molecular subtypes (CMS), cancer stem cell (CSC) index, tumor microenvironment (TME), gene mutations, and response to immunotherapy. Utilizing three machine learning algorithms (LASSO, Xgboost, and Decision Tree), we screen key ARGs associated with ARCs, further validated in independent cohorts. A prognostic signature based on key ARGs was developed and analyzed at the scRNA-seq level. Validation of gene expression in external cohorts, clinical tissues, and blood samples was conducted via RT-PCR assay.

Results

Two distinct ARC subtypes were identified and were significantly associated with patient survival, clinical features, CMS, CSC index, and TME, but not with gene mutations. Four genes (S100A4, COL3A1, TIMP1, and APP) were identified as key ARCs, capable of distinguishing ARC subtypes. The prognostic signature based on these genes effectively stratified patients into high- or low-risk categories. scRNA-seq analysis showed that these genes were predominantly expressed in immune cells rather than in cancer cells. Validation in two external cohorts and through clinical samples confirmed significant expression differences between CRC and controls.

Conclusion

This study identified two ARG subtypes in CRC and highlighted four key genes associated with these subtypes, offering new insights into personalized CRC treatment strategies.
Preoperative sequential chemotherapy and hypofractionated radiotherapy combined with comprehensive surgical resection for high-risk soft tissue sarcomas: a retrospective study
Authors: Qu Guoxin , Tian Zhichao , Wang Jiaqiang , Yang Chengliang , Niu Xiaohui , Yao Weitao
Published: June 2024

Introduction

The management of soft tissue sarcomas presents considerable therapeutic challenges. This study was designed to assess the efficacy of neoadjuvant sequential chemotherapy and hypofractionated radiotherapy in conjunction with extensive surgical resection for the treatment of high-risk soft tissue sarcomas.

Materials and methods

We performed a retrospective review of 31 high-risk soft tissue sarcoma patients treated at our institution from June 2021 to June 2023. The cohort consisted of 21 males and 10 females with a mean age of 55.7 years and included both initial and recurrent disease presentations. Our treatment regimen comprised two to three cycles of neoadjuvant chemotherapy coupled with hypofractionated radiotherapy, delivered at 5 Gy per fraction to a total dose of 25–35 Gy across 5–7 days, prior to surgical resection aimed at achieving wide margins. Data collection was systematic, covering surgical outcomes, chemoradiotherapy-related complications, and prognostic factors.

Results

All patients completed the prescribed course of neoadjuvant chemoradiotherapy. 29% patients experienced grade 3+ chemotherapy toxicity, necessitating a reduction or interruption in their chemotherapy regimen. Limb preservation was accomplished in 30 patients finally. Response evaluation using RECIST 1.1 criteria post-neoadjuvant therapy revealed 9.7% with PD, 58.1% with SD, 29% with a PR, and 3.2% with a CR, culminating in an ORR of 32.2%. Postoperative complications included superficial wound infections in four patients and deep incisional infections in another four. 6 patients had developed metastasis, and 3 patients were still alive. Two experienced local recurrence. One-year DFS was 79.3%, with a one-year OS rate of 89.6%.

Conclusion

Neoadjuvant sequential chemotherapy and hypofractionated radiotherapy followed by extensive surgical resection represents an effective treatment paradigm for high-risk soft tissue sarcomas. This multimodal approach not only facilitates tumor reduction but also significantly reduces the risks of local recurrence and distant metastasis.
Case report and literature review: management of Paxlovid (nirmatrelvir/ritonavir)-induced acute tacrolimus toxicity in a patient with systemic lupus erythematosus
Authors: Jiang Chenxiao , Yan Xiaodi , Xia Peng , Luo Xuemei , Zheng Haoyue , Tong Hanwen , Liu Yun , Zhu Huaijun , Xu Peng , Wang Jun
Published: June 2024

Despite the availability of effective vaccines and treatments for SARS-CoV-2, managing COVID-19 in patients with systemic lupus erythematosus (SLE) remains challenging, particularly considering drug-drug interactions (DDIs). Here, we present a case of DDIs between Tacrolimus (Tac) and nirmatrelvir/ritonavir (NMV/r) in a 32-year-old male with SLE. Following self-administration of NMV/r and resumption of Tac after 5 days, the patient experienced acute nephrotoxicity and neurotoxicity, accompanied by supratherapeutic Tac levels, despite Tac being withheld during NMV/r. The primary cause of this acute toxicity is attributed to ritonavir’s inhibitory effect on both CYP3A4 enzymes and P-glycoprotein. Upon admission, Tac was discontinued, and supportive therapies were initiated. Phenytoin, a CYP3A4 inducer, was administered to lower Tac levels under the guidance of clinical pharmacists, effectively alleviating the patient’s acute toxic symptoms. The half-life of Tac during the treatment of phenytoin was calculated to be 55.87 h. And no adverse reactions to phenytoin were observed. This case underscores the persistence of enzyme inhibition effects and demonstrates the effectiveness and safety of utilizing CYP3A4 enzyme inducers to mitigate Tac concentrations. Furthermore, it emphasizes the importance of healthcare providers and patients being vigilant about DDIs in Tac recipients. Lastly, it highlights the indispensable role of pharmacist involvement in clinical decision-making and close monitoring in complex clinical scenarios. Although our findings are based on a single case, they align with current knowledge and suggest the potential of individualized combination therapy in managing challenging COVID-19 cases in immunocompromised patients.
Cross-modal retrieval based on multi-dimensional feature fusion hashing
Authors: Ren Dongxiao , Xu Weihua
Published: June 2024

Along with the continuous breakthrough and popularization of information network technology, multi-modal data, including texts, images, videos, and audio, is growing rapidly. We can retrieve different modal data to meet our needs, so cross-modal retrieval has important theoretical significance and application value. In addition, because the data of different modalities can be mutually retrieved by mapping them to a unified Hamming space, hash codes have been extensively used in the cross-modal retrieval field. However, existing cross-modal hashing models generate hash codes based on single-dimension data features, ignoring the semantic correlation between data features in different dimensions. Therefore, an innovative cross-modal retrieval method using Multi-Dimensional Feature Fusion Hashing (MDFFH) is proposed. To better get the image’s multi-dimensional semantic features, a convolutional neural network, and Vision Transformer are combined to construct an image multi-dimensional fusion module. Similarly, we apply the multi-dimensional text fusion module to the text modality to obtain the text’s multi-dimensional semantic features. These two modules can effectively integrate the semantic features of data in different dimensions through feature fusion, making the generated hash code more representative and semantic. Extensive experiments and corresponding analysis results on two datasets indicate that MDFFH’s performance outdoes other baseline models.
Effect of network structure on the accuracy of resilience dimension reduction
Authors: Liu Min , Guo Qiang , Liu Jianguo
Published: June 2024

Dimension reduction is an effective method for system’s resilience analysis. In this paper, we investigate the effect of network structure on the accuracy of resilience dimension reduction. First, we introduce the resilience dimension reduction method and define the evaluation indicator of the resilience dimension reduction method. Then, by adjusting node connections, preferential connection mechanisms, and connection probabilities, we generate artificial networks, small-world networks and social networks with tunable assortativity coefficients, average clustering coefficients, and modularities, respectively. Experimental results for the gene regulatory dynamics show that the network structures with positive assortativity, large clustering coefficient, and significant community can enhance the accuracy of resilience dimension reduction. The result of this paper indicates that optimizing network structure can enhance the accuracy of resilience dimension reduction, which is of great significance for system resilience analysis and provides a new perspective and theoretical basis for selecting dimension reduction methods in system resilience analysis.
Sensitivity analysis of non-uniform rational B-splines–based finite element/boundary element coupling in structural-acoustic design
Authors: Xu Yanming , Yang Sen
Published: June 2024

For the purpose of modeling the acoustic fluid-structure interaction using direct differentiation method and conducting a structural-acoustic sensitivity analysis, a coupling approach based on the finite element method and the fast multipole boundary element method is suggested. Non-uniform rational B-splines isogeometric analysis bypasses the difficult volume parameterization procedure in the isogeometric finite element method and the time-consuming meshing process in classical finite element/boundary element method, allowing numerical analysis on computer-aided design models to be completed directly. The finite element/fast multipole boundary element method based on non-uniform rational B-splines isogeometric analysis enables the numerical prediction of the effects of arbitrarily formed vibrating structures on the sound field. Several numerical examples are shown to demonstrate the usefulness and efficiency of the proposed method.
Does a single session of transcranial direct current stimulation enhance both physical and psychological performance in national- or international-level athletes? A systematic review
Authors: Yu Ying , Zhang Xinbi , Nitsche Michael A. , Vicario Carmelo M. , Qi Fengxue
Published: June 2024

Some studies showed that a single session of transcranial direct current stimulation (tDCS) has the potential of modulating motor performance in healthy and athletes. To our knowledge, previously published systematic reviews have neither comprehensively investigated the effects of tDCS on athletic performance in both physical and psychological parameters nor investigated the effects of tDCS on high-level athletes. We examined all available research testing a single session of tDCS on strength, endurance, sport-specific performance, emotional states and cognitive performance for better application in competition and pre-competition trainings of national- or international-level athletes. A systematic search was conducted in PubMed, Web of Science, EBSCO, Embase, and Scopus up until to June 2023. Studies were eligible when participants had sports experience at a minimum of state and national level competitions, underwent a single session of tDCS without additional interventions, and received either sham tDCS or no interventions in the control groups. A total of 20 experimental studies (224 participants) were included from 18 articles. The results showed that a single tDCS session improved both physical and psychological parameters in 12 out of the 18 studies. Of these, six refer to the application of tDCS on the motor system (motor cortex, premotor cortex, cerebellum), five on dorsolateral prefrontal cortex and two on temporal cortex. The most sensitive to tDCS are strength, endurance, and emotional states, improved in 67%, 75%, and 75% of studies, respectively. Less than half of the studies showed improvement in sport-specific tasks (40%) and cognitive performance (33%). We suggest that tDCS is an effective tool that can be applied to competition and pre-competition training to improve athletic performance in national- or international-level athletes. Further research would explore various parameters (type of sports, brain regions, stimulation protocol, athlete level, and test tasks) and neural mechanistic studies in improving efficacy of tDCS interventions.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022326989, identifier CRD42022326989.
Leader ethical voice and subordinate job performance: the chain mediating role of subordinate identification with leader and leader-member exchange
Authors: Xia Fubin , Lu Ping , Wang Lifang
Published: June 2024

Introduction

Ethical voice is a valuable ethical behavior that enables organizations to promptly recognize and rectify unethical issues and practices, thus preventing severe dilemmas and crises. Despite its importance, the extant literature has yet to fully explore the impact of a leader’s ethical voice on subordinate outcomes. This study bridges this gap by integrating social identity theory and social exchange theory to scrutinize the process by which a leader’s ethical voice affects subordinate task performance.

Methods

We employ a serial mediation model to explore the mechanisms by which a leader’s ethical voice enhances subordinates’ task performance. Our theoretical framework is empirically validated using a dataset that includes 449 subordinate-leader pairings from Chinese enterprises.

Results

The survey results demonstrate that a leader’s ethical voice has a significant positive impact on subordinate task performance. Subordinate identification with leader and leader-member exchange not only individually mediate the effects of a leader’s ethical voice on subordinate task behavior but also jointly serve as a chain-mediated mechanism in the influence of a leader’s ethical voice on subordinate task behavior.

Discussion

These findings illuminate the substantial effects that ethical leadership behaviors exert on employee performance and offer fresh perspectives on the intricate dynamics that govern this influence.
Intercultural therapy with Ultra-Orthodox Jews in Israel: the complexity of the encounter between secular therapists and Haredi clients
Authors: Doron Einat , Tobis Sławomir , Domaradzki Jan
Published: June 2024

This paper explores the exceptional intercultural encounter between secular therapists and Ultra-Orthodox Jews in Israel, focusing on two key aspects. Firstly, it explores the distinctive attributes and conflicts inherent in treating Ultra-Orthodox individuals. On the one hand is the secular Israeli therapist, whose base is in Western philosophy that prioritizes individuality, cultural diversity, and tolerance of differences. On the other hand is the Haredi client, entrenched in values from Jewish tradition and religious principles that amplify solidarity and collectivism while rejecting prevalent secular culture. The existing socio-political climate in Israel often positions these two as potentially conflicting cultures. Secondly, the paper seeks to illuminate the uncommon dynamics of the minority-majority power balance within the therapeutic relationship. In contrast to prevalent literature in intercultural therapy, which typically frames the client as a representative of a disadvantaged minority and the therapist as a representative of a dominant majority, this article aims to unravel a nuanced power balance, where those in the minority perceive the dominant culture both as a threat to its way of life and as a despised entity, but paradoxically rely entirely on its financial support. This reveals a complex and intricate interplay of dominance and dependence, shaping a therapeutic relationship that defies conventional expectations.
Attitudes and experiences of cancer patients toward the provision of audio recordings of their own medical encounter: a cross-sectional online survey
Authors: Topf Cheyenne , Scholl Isabelle , Hahlweg Pola
Published: June 2024

Background

The provision of audio recordings of their own medical encounters to patients, termed consultation recordings, has demonstrated promising benefits, particularly in addressing information needs of cancer patients. While this intervention has been explored globally, there is limited research specific to Germany. This study investigates the attitudes and experiences of cancer patients in Germany toward consultation recordings.

Methods

We conducted a nationwide cross-sectional quantitative online survey, informed by semi-structured interviews with cancer patients. The survey assessed participants’ attitudes, experiences and desire for consultation recordings in the future. The data was analyzed using descriptive statistics and subgroup analyses.

Results

A total of 287 adult cancer patients participated. An overwhelming majority (92%) expressed a (very) positive attitude. Overall, participants strongly endorsed the anticipated benefits of the intervention, such as improved recall and enhanced understanding. Some participants expressed concerns that physicians might feel pressured and could become more reserved in their interactions with the use of such recordings. While a small proportion (5%) had prior experience with audio recording medical encounters, the majority (92%) expressed interest in having consultation recordings in the future.

Discussion

We observed positive attitudes of cancer patients in Germany toward consultation recordings, paralleling international research findings. Despite limited experiences, participants acknowledged the potential benefits of the intervention, particularly related to recalling and comprehending information from medical encounters. Our findings suggest that the potential of the intervention is currently underutilized in German cancer care. While acknowledging the possibility of a positive bias in our results, we conclude that this study represents an initial exploration of the intervention’s potential within the German cancer care context, laying the groundwork for its further evaluation.
A cross-sectional analysis of gender and psychological well-being among older Taiwanese adults
Authors: Fergus Deleon N. , Chen Yi-Hua , Chuang Ying-Chih , Ma Ai-hsuan Sandra , Chuang Kun-Yang
Published: June 2024

Background

Psychological well-being (PWB) facilitates good health. Few studies have taken into consideration gender and how it can affect PWB within a sociocultural context. This study aims to determine if relationships between social, health, behavioral, and socioeconomic factors on PWB among older Taiwanese adults are affected by gender.

Methods

Data were obtained from the 2016 Taiwan Mental Health Survey. A representative sample, of 2,286 individuals, was created using multistage proportional probability. Participants were interviewed at their homes using a structured questionnaire. Inclusion criteria were Taiwanese citizenship, age ≥ 55 years, and the ability to provide informed consent. Participants 65 years and above were selected for the study sample n = 1,533. An 18-item version of Ryff’s PWB scale was used to determine PWB. The median value was used to categorize low and high PWB. Logistic regression analyses were used to examine predictors of PWB stratified by gender.

Results

Chronic disease, unemployment, and financial dependence negatively impacted men’s PWB. Satisfaction with living environment and family relationships positively impacted women’s PWB. Unique characteristics of older men, women, and culture account for this.

Conclusion

Gender-specific interventions aimed at promoting PWB in older adults are needed. Recommendations include educational programs, social support workshops, and community engagement initiatives.
Teen dating violence: predictive role of sexism and the mediating role of empathy and assertiveness based on gender
Authors: Villanueva-Blasco Víctor José , Iranzo Begoña , Mateu-Mollá Joaquín , Carrascosa Laura , Gómez-Martínez Sandra , Corral-Martínez Marta , Mitjans Mª Teresa , Hernández-Jiménez Mª Jesús
Published: June 2024

Background

Despite efforts to prevent dating violence among adolescents, it remains a major problem with multiple negative consequences. Sexist beliefs, empathy, and assertiveness influence teen dating violence (TDV) with potential gender differences.

Objectives

(1) Determine gender disparities in TDV perpetration and victimization, including relational, verbal-emotional, and physical aspects, as well as roles; (2) Analyze gender variations in sexism, empathy, assertiveness, and their relationship with TDV; (3) Establish a predictive model of sexism in TDV with empathy and assertiveness as mediators for both genders.

Participants and setting

A sample of 862 secondary school students (50.2% females, 49.8% males; mean age: 14.1 years) from diverse regions in Spain participated.

Methods

TDV was measured using the Conflict in Adolescent Dating Relationships Inventory (CADRI) in a cross-sectional study. Sexism, empathy, and assertiveness were assessed using the Ambivalent Sexism Inventory (ASI), Interpersonal Reactivity Index (IRI), and Assertiveness Inventory for Students Questionnaire (AISQ), respectively.

Results

Females exhibited higher TDV perpetration, specifically verbal-emotional TDV. Males showed more relational TDV and hostile sexism, while no benevolent sexism differences were observed. Mediation models demonstrated sexism, assertiveness, and empathy as individual predictors of TDV, with varying mediation effects. Personal distress partially mediates the link between sexism and TDV perpetration or victimization in males, while practical personal ability mediates between sexism and TDV perpetration in females.

Conclusion

Sexism predicts both perpetration and victimization in TDV, linked to empathy and assertiveness. Notably, specific dimensions of empathy and assertiveness mediate the connection between sexism and TDV, displaying gender-specific patterns. Preventive measures should consider personal distress in male perpetrators/victims and practical personal ability in female perpetrators.
Incorporating gendered analysis and flexibility in heavy work investment studies: a systematic literature review
Authors: Escudero-Guirado Carmen , Fernández-Rodríguez Lourdes , Nájera-Sánchez Juan-José
Published: June 2024

Introduction

Significant impacts of heavy work investment on employee well-being and organizational performance have prompted its increasing importance as a research topic. The findings about good or evil of these repercussions are nonetheless inconclusive. The intersection of Heavy Work Investment construct with gender has not been explicitly addressed by previous literature review and research. Besides, the relevance of flexibility for women, as one of the key factors for successful work-family balance management, still remains to be analyzed.

Methods

A literature review on Heavy Work Investment was conducted using the SPAR-4-SLR protocol, wherein 83 articles were selected from a pool of 208 previously identified works. Bibliometric and content analysis techniques were employed, including co-word analysis, to evaluate research production, impact, and trends in the gender perspective within Heavy Work Investment.

Results

As a result, a strategic diagram illustrates thematic topics, providing a clear understanding of the field’s structure and evolution. Six thematic groups were identified, around work-family conflict as the central theme.

Discussion

The explicit consideration of a gender perspective in literature involves nuanced differences regarding the conclusions of studies with a broader focus. First, the emerging prominence of studies on China and Japan becomes clear with gender as the specific focus of the review, aiming to clarify the experiences women face in more traditional societies with a more decisive division of roles. Second, there is a shift in interest regarding the analysis of Job Demands and Job Resources. Despite the apparent decline in interest in the former, the focus in gender literature clearly shifts toward the side of Job Resources, showing potential for the future. It could be understood that in a context of talent war and employee retention efforts, priority is given to better understanding of facilitating individual and organizational factors for work-life balance, especially for women. Future research areas are identified, including gender differences in organizational support and the impact of flexible work on the work-life balance, providing valuable insights for academia, practitioners, and organizations. The need for more comprehensive cross-cultural and gender research is also made clear.
A methodology to globally assess ectodomain shedding using soluble fractions from the mouse brain
Authors: Lobete Miguel , Salinas Tamel , Izquierdo-Bermejo Sara , Socas Silvia , Oset-Gasque María Jesús , Martín-de-Saavedra M. Dolores
Published: June 2024

Ectodomain shedding (ES) is a fundamental process involving the proteolytic cleavage of membrane-bound proteins, leading to the release of soluble extracellular fragments (shed ectodomains) with potential paracrine and autocrine signaling functions. In the central nervous system (CNS), ES plays pivotal roles in brain development, axonal regulation, synapse formation, and disease pathogenesis, spanning from cancer to Alzheimer’s disease. Recent evidence also suggests its potential involvement in neurodevelopmental conditions like autism and schizophrenia. Past investigations of ES in the CNS have primarily relied on cell culture supernatants or cerebrospinal fluid (CSF) samples, but these methods have limitations, offering limited insights into how ES is modulated in the intact brain parenchyma. In this study, we introduce a methodology for analyzing shed ectodomains globally within rodent brain samples. Through biochemical tissue subcellular separation, mass spectrometry, and bioinformatic analysis, we show that the brain’s soluble fraction sheddome shares significant molecular and functional similarities with in vitro neuronal and CSF sheddomes. This approach provides a promising means of exploring ES dynamics in the CNS, allowing for the evaluation of ES at different developmental stages and pathophysiological states. This methodology has the potential to help us deepen our understanding of ES and its role in CNS function and pathology, offering new insights and opportunities for research in this field.
Brain network functional connectivity changes in long illness duration chronic schizophrenia
Authors: Bai Yin Xia , Luo Jia Xin , Peng Duo , Sun Jing Jing , Gao Yi Fang , Hao Li Xia , Tong B. G. , He Xue Mei , Luo Jia Yu , Liang Zi Hong , Yang Fan
Published: June 2024

Introduction

Chronic schizophrenia has a course of 5 years or more and has a widespread abnormalities in brain functional connectivity. This study aimed to find characteristic functional and structural changes in a long illness duration chronic schizophrenia (10 years or more).

Methods

Thirty-six patients with a long illness duration chronic schizophrenia and 38 healthy controls were analyzed by independent component analysis of brain network functional connectivity. Correlation analysis with clinical duration was performed on six resting state networks: auditory network, default mode network, dorsal attention network, fronto-parietal network, somatomotor network, and visual network.

Results

The differences in the resting state network between the two groups revealed that patients exhibited enhanced inter-network connections between default mode network and multiple brain networks, while the inter-network connections between somatomotor network, default mode network and visual network were reduced. In patients, functional connectivity of Cuneus_L was negatively correlated with illness duration. Furthermore, receiver operating characteristic curve of functional connectivity showed that changes in Thalamus_L, Rectus_L, Frontal_Mid_R, and Cerebelum_9_L may indicate a longer illness duration chronic schizophrenia.

Discussion

In our study, we also confirmed that the course of disease is significantly associated with specific brain regions, and the changes in specific brain regions may indicate that chronic schizophrenia has a course of 10 years or more.
Machine learning algorithms to predict healthcare-seeking behaviors of mothers for acute respiratory infections and their determinants among children under five in sub-Saharan Africa
Authors: Yehuala Tirualem Zeleke , Agimas Muluken Chanie , Derseh Nebiyu Mekonnen , Wubante Sisay Maru , Fente Bezawit Melak , Yismaw Getaneh Awoke , Tesfie Tigabu Kidie
Published: June 2024

Background

Acute respiratory infections (ARIs) are the leading cause of death in children under the age of 5 globally. Maternal healthcare-seeking behavior may help minimize mortality associated with ARIs since they make decisions about the kind and frequency of healthcare services for their children. Therefore, this study aimed to predict the absence of maternal healthcare-seeking behavior and identify its associated factors among children under the age 5 in sub-Saharan Africa (SSA) using machine learning models.

Methods

The sub-Saharan African countries’ demographic health survey was the source of the dataset. We used a weighted sample of 16,832 under-five children in this study. The data were processed using Python (version 3.9), and machine learning models such as extreme gradient boosting (XGB), random forest, decision tree, logistic regression, and Naïve Bayes were applied. In this study, we used evaluation metrics, including the AUC ROC curve, accuracy, precision, recall, and F-measure, to assess the performance of the predictive models.

Result

In this study, a weighted sample of 16,832 under-five children was used in the final analysis. Among the proposed machine learning models, the random forest (RF) was the best-predicted model with an accuracy of 88.89%, a precision of 89.5%, an F-measure of 83%, an AUC ROC curve of 95.8%, and a recall of 77.6% in predicting the absence of mothers’ healthcare-seeking behavior for ARIs. The accuracy for Naïve Bayes was the lowest (66.41%) when compared to other proposed models. No media exposure, living in rural areas, not breastfeeding, poor wealth status, home delivery, no ANC visit, no maternal education, mothers’ age group of 35–49 years, and distance to health facilities were significant predictors for the absence of mothers’ healthcare-seeking behaviors for ARIs. On the other hand, undernourished children with stunting, underweight, and wasting status, diarrhea, birth size, married women, being a male or female sex child, and having a maternal occupation were significantly associated with good maternal healthcare-seeking behaviors for ARIs among under-five children.

Conclusion

The RF model provides greater predictive power for estimating mothers’ healthcare-seeking behaviors based on ARI risk factors. Machine learning could help achieve early prediction and intervention in children with high-risk ARIs. This leads to a recommendation for policy direction to reduce child mortality due to ARIs in sub-Saharan countries.
Current syphilis infection in virally suppressed people living with HIV: a cross-sectional study in eastern China
Authors: He Lin , Pan Xiaohong , Yang Jiezhe , Zheng Jinlei , Luo Mingyu , Cheng Wei , Chai Chengliang
Published: June 2024

Background

Antiretroviral therapy (ART) has been shown to reduce human immunodeficiency virus (HIV) viral replication and ultimately achieve viral suppression and eliminate HIV transmission. However, little is known about the impact of viral suppression on high-risk behaviors and sexually transmitted infections (STIs).

Objective

This study aimed to assess the rates of current syphilis infection in virally suppressed people living with HIV (PLWH) and whether with the duration of ART can reduce the current syphilis infection in eastern China.

Method

We conducted a cross-sectional survey of PLWH in Zhejiang Province, China, in 2022. PLWH who were on ART >6 months and were virally suppressed (viral load <50 copies/mL) were included in the study. Data were collected from the National Epidemiological Database of Zhejiang Province and all participants were tested for viral load and current syphilis. Multivariable logistic regression was used to identify risk factors associated with current syphilis infection.

Result

A total of 30,744 participants were included in the analysis. 82.7% of participants were male, the mean age was 44.9 ± 14.1 years, 84.9% had received ART in a hospital setting, the mean time on ART was 5.9 ± 3.1 years and 5.6% of participants were infected with current syphilis. Multivariable logistic regression showed that being male [adjusted odds ratio (aOR): 2.12, 95% confidence interval (CI): 1.69–2.66], high level of education (aOR: 1.23, 95% CI: 1.02–1.49), homosexual route of HIV infection (aOR: 1.80, 95% CI: 1.60–2.04), non-local registered residence (aOR: 1.29, 95% CI: 1.11–1.51), had history of STIs before HIV diagnosis (aOR: 1.95, 95 % CI: 1.75–2.18) and treatment provided by a municipal hospital (aOR: 2.16, 95% CI: 1.31–3.55) were associated with increased risk of current syphilis infection. Being married (aOR: 0.67, 95% CI: 0.58–0.76) was associated with a decreased risk of current syphilis infection.

Conclusion

Our findings revealed a high rate of current syphilis infection among virally suppressed PLWH in eastern China. Duration of ART did not reduce the prevalence of current syphilis infection. Targeted interventions to reduce current syphilis infection should be prioritized for subgroups at higher risk.
Physical exercise and mental health among older adults: the mediating role of social competence
Authors: Hou Bin , Wu Yuxin , Huang Yuqi
Published: June 2024

Background

Healthy aging is crucial to the quality of life of older adults, of which mental health is an essential part. Physical exercise strongly affects their mental health and can alleviate psychological problems to a certain extent. Nevertheless, the correlation between physical exercise and the mental health of older adults individuals, as well as the underlying mechanism by which physical exercise impacts mental health, remains rather ambiguous.

Methods

We utilized multiple linear regression models to investigate the relationship between physical activity and mental health in 3,240 persons aged 60 and up. The propensity score matching (PSM) method was used to assess the robustness of the regression results. In addition, sequential recursive models were employed to investigate the mediating role of social competence in the link between physical activity and mental health.

Results and discussion

We discovered a strong favorable association between physical exercise and mental health, which was mediated by social competence. Furthermore, the effect of physical exercise on mental health differed across older persons from various socioeconomic backgrounds.

Conclusion

Older adults should strengthen their understanding of the role of physical exercise. Sports organizations that serve older adults by providing resources and services to help them maintain physical fitness and by hosting sports activities and competitions according to their needs should be established.
Prosperity in progress: a new look at archetypes of successful community development
Authors: Hampton Midas , O’Hara Sabine
Published: June 2024

This study navigates the terrain of community development in metropolitan areas across the United States (US), spotlighting the interplay between stakeholder engagement, development success, and distinct types of community development characteristics. While urban centers in US cities experienced disinvestment and urban flight for more than 5 decades, they now experience renewed interest amidst the complexities of rampant urbanization. Gentrification and displacement are some of the critical consequences of urban re-development, which warrants the exploration of the success metrics that turn disinvested communities into thriving ones. Methodologically, archetype analysis is employed to examine 73 case studies reported by the United States Department of Housing & Urban Development (HUD) as examples of successful development. The case studies span 37 US states and 67 cities. The analysis utilizes the Distressed Communities Index (DCI) as a supporting metric and offers an intermediate level of abstraction between a case-by-case analysis of successful development strategies and a generalized approach that assumes that one strategy fits all. Instead, the analysis identifies four distinct types of successful community development archetypes based on five relevant characteristics that emerged from our analysis: (1) public investments, (2) private investment (3) development plans, (4) stakeholder engagement, and (5) the DCI. The four identified archetypes represent unique Community Development Success pathways with specific development characteristics. Understanding the diversity reflected in these distinct archetypes is crucial for policymakers and stakeholders seeking to address the specific needs and challenges of each development success type. This can inform more targeted policy initiatives for fostering prosperity and vitality in diverse communities across the US and beyond.
Spatial and temporal patterns of diffuse attenuation coefficient in Guánica, Puerto Rico: 15 years after development of a watershed management plan
Authors: Guzmán-Morales Alba L. , Armstrong Roy A. , Cruz-Motta Juan J. , Hernández William J.
Published: June 2024

Decreased water quality in coastal environments due to land alterations by human activities has caused stressed and degraded coral reefs worldwide. The consequences of decreased water quality are not limited to coral reefs but also affect the quality of people’s lives by increasing the incidence of diseases, so areas highly impacted have been prioritized for management. The Guánica Bay Watershed Management Plan was developed to reduce the non-point sources of pollution that arrive at the bay and to protect adjacent coral reefs, however, 15 years have passed since its creation and management actions have not been evaluated. The purpose of this study was to evaluate the effectiveness of the management actions implemented in the Guánica Bay watershed. Therefore, the objective of this study was to describe temporal trends (2002–2008 and 2016–2022) of remotely sensed diffuse attenuation coefficient at 490 nm (Kd490), a water quality indicator, in one managed (Guánica Bay) and three non-managed (Guayanilla Bay, Descalabrado River, and Guanajibo River) estuaries in Southwestern Puerto Rico. This was achieved by integrating ocean-color satellite imagery from MERIS-Envisat and OLCI-Sentinel-3 sensors that were sampled using a beyond-Before-After-Control-Impact (beyond-BACI) approach. An additional oceanic site was selected to evaluate continuity between sensors estimates. The imagery was processed using SNAP to extract Kd490 values in the estuaries. The analysis for the beyond-BACI found significant differences between periods (before and after) but the changes were unique to each location within estuary. The lowest Kd490 values and variability within estuary was observed in Guánica (range 0.05–0.1 m-1) and the highest Kd490 values were observed in Guayanilla (0.35 m-1). The southern estuaries showed similar temporal trends, all having a peak in 2018 and a trough in 2020. Kd490 did not decrease in Guánica after the implementation of management actions, which can be related to the passage of several hurricanes during the after period. Further analysis should be done as new data is available and after the implementation of the last management actions suggested in the plan.
Sickle cell anemia and early stroke detection and prevention in Nigeria
Authors: Ahmed Kudirat Abdulkareem , Bello-Manga Halima , Jordan Lori C.
Published: June 2024

Sickle cell disease (SCD) is the most common hereditary blood disorder worldwide, and sickle cell anemia (SCA), the homozygous state of SCD, is the most common and severe variant of the disease. Nigeria has the highest burden of SCA in the world. Hemolysis and vaso-occlusion can lead to a wide range of complications, including stroke which is one of the most devastating manifestations of SCA with significant morbidity and mortality. SCA remains the leading cause of stroke in black children. Without any intervention, strokes occur in approximately 11% of children with SCA before their 20th birthday, with the greatest risk in very young children between 2 and 5 years of age. In resource-constrained countries, where the burden of SCA is highest, stroke is underreported, hence the need to develop strategies for stroke prevention and early detection. Improving awareness among healthcare providers and the community can significantly reduce stroke rates and improve stroke detection. The goal of this manuscript is to discuss the progress that has been made in stroke prevention and detection in children with SCA in Nigeria and outline current challenges and future goals. We believe that our experience will be valuable not only in Nigeria which has the highest burden of SCA globally, but also in other low- and middle-income countries.