bluuebunny/crossref_metadata_2025 huggingface dataset:
KEMANDIRIAN USIA DINI DI SUKU BAJO
Authors: HEWI LA
Published: November 2024

Abstract: This study aims to: (1) Describe the forms of independence, (2) Describe the parenting parents establish the independence, (3) Describe the attachment of children with parents establish the independence, (4) Describe the role of teachers in shaping the independence. Analysis of the data used that model of Miles and Huberman. The research data obtained from observation, interviews and documentation. Results of the study include: (1) There is a child who has not seen an independent behavior, child behavior only seen one self-contained and there are children who have seen all mandirinya behavior, (2) Parents with permissive parenting tend to have children who are not independent and the parents with authoritative parenting tend to have an independent child, (3) Stickiness children with mothers in different schools with home, (4) Teachers make efforts to foster self-confidence of children and train children to be responsible.
Keywords: independent, parenting, attachment, children, teachers
PENINGKATAN KEMAMPUAN GERAK LOKOMOTOR MELALUI PERMAINAN LARI ESTAFET MODIFIKASI
Authors: WULAN DWI SEPTI ANJAS
Published: November 2024

Abstract. This study aims to determinan to increase locomotor skiil in early childhood Through game relay modification. The study was conducted on group B kindergarten with of sixteen children. This study action research by model Kemmis & Taggart. This research was conducted by using a provision of the cycle. Each cycle has four main activities: planning, action, observation dan refleksion. This research consist of two cycles, each cycle consist of 8 times in actions. Analysis of the data used quantitative and qualitative approaches. Analysis of quantitative data used descriptive statistics that compare the results obtained from the first cycle. While the analysis of qualitative data used analizing data from the field notes and interviews during the research by steps of data reduction, data display and data verivication. In the pre cycle persentage yield 47,08% after the act of the first cycle increased to 62,39% and 82,03% second cycle becomes. The results showed an increase locomotor skiils in aerly chillhood B gruop conducted through learning game relay modification.
Keywords: Locomotor Skiils, Game Relay Modification
PROGRAM UNDERWEAR RULESUNTUK MENCEGAH KEKERASAN SEKSUAL PADA ANAK USIA DINI
Authors: JUSTICIA RISTY
Published: November 2024

Abstract: This article discusses the conceptual studies relating to the prevention of sexual abuse in early childhood through underwear program rules. Program rules underwear is a place for parents and teachers to teach how to provide sex education for early childhood as an effort to prevent the occurrence of sexual abuse in children. The good efforts to prevent sexual violence by people who are closest to the child, parents and teachers. Early childhood is an individual who has the true curiosity one of which is sexual knowledge. As for the topics that are presented in this article include several things, among others, the concept of early childhood sex education, sexual abuse in early childhood, early childhood sex education.. The authors in this article so that a parent can anticipate sexual abuse in early childhood, which may be giving out advice and efforts so that the child can keep his body of people who intend to poor children. In addition, the child can know the boundaries of others as well as touch guard against malicious behavior of the people around the child.
Keywords: sex education, child abuse, early childhood
PENGARUH KEGIATAN PAINTING DAN KETERAMPILAN MOTORIK HALUS TERHADAP KREATIVITAS ANAK USIA DINI DALAM SENI LUKIS
Authors: KURNIA SELIA DWI
Published: November 2024

Abstract: The purpose of this research were to know the effect of painting activity and fine motor skill toward the creativity of early childhood in painting art of group B of kindergarten. Method in this research used experimental research with treatment design by level 2x2. Sample of this research were 66 students. The prosedure of collecting data used multistage samplingtechnique. Analysis data in this research used two away ANAVA. The result of this research were; 1) the creativity of early childhood in painting are toward thr children who got finger painting was higher than the children who got brush painting, 2) there were interaction beetwen painting activity fine motor skill toward the creativity of early childhood in painting art, 3) the result of children creativity in painting art toward children who had high fine motor skill by giving finger painting activity were higher then children who got brush painting activity, 4) the result of the creativity of early childhood in painting art toward group who had low fine motor skill which  was given in finger painting activity was lower  than group who was given brush painting activity.
Keywords: painting activity, fine motor skill, and creativity of early childhood in painting art
Pelatihan Pembuatan Kerajinan Tangan Bernilai Ekonomis dari Limbah Anorganik di Desa Banjarwaru Kecamatan Nusawangu
Authors: Pramita Ayu , Ganjar Ndaru Ikhtiagung  , Ilma Fadlilah
Published: November 2024

Desa Banjarwaru Kecamatan Nusawungu Kabupaten Cilacap memiliki luas desa ± 185,3 ha. Desa Banjarwaru memiliki 29 RT dan 8 RW yang terdiri dari 8 dusun antara lain: desa Sidamulya, desa Bokol Kulon, desa Bokol Wetan, desa Sigandu, desa Kubang,desa Kubang Kidul, desa Karangreja dan desa Banjarwaru.  Selain itu terdapat para kader Posyandu dan PKK yang setiap bulan melakukan pertemuan rutinan mengenai pencegahan dan penanggulangan kesehatan balita. Namun, ibu-ibu yang tergabung dalam kader Posyandu dan PPK serta masyarakat Desa Banjarwaru belum mengetahui pemanfaatan pengolahan sampah organik dan anorganik. Oleh karena itu, penting untuk memberikan kesadaran sejak dini masyarakat  agar dapat memilah dan mengolah jenis-jenis sampah yang ada di lingkungan sekitarnya dengan cara yang tepat. Berawal dari permasalahan tersebut, kegiatan pengabdian kepada masyarakat (PkM) ini bertujuan memberikan pemaparan materi mengenai klasifikasi limbah anorganik dan organik serta juga pemilahan dan pengolahan dengan pemberian pelatihan  kerajinan tangan  dari kertas koran, botol plastik dan kemasan sachet. Di samping itu, meminimalisir volume limbah anorganik dan melestarikan lingkungan.    Metode   yang    digunakan    dalam    kegiatan pengabdian kepada masyarakat ini berbasis kelompok sebagai    media    pembelajaran    dan    pelatihan, pendampingan, perencanaan dan pemantauan. Hasil  pengabdian  ini  diharapkan mampu memberikan peningkatan pemahaman dan ketrampilan masyarakat tentang pemilahan dan pengolahan limbah anorganik khususnya kertas koran, botol plastik dan kemasan sachet dengan cara 3R atau 5R.
Therapeutic Effectiveness of SNOT 22-Based Interdose Interval Adjustment of Dupilumab for Chronic Rhinosinusitis With Nasal Polyps
Authors: Yoon So Yeon , Cha HyunKyung , Hong Seung-No , Yang Min-Suk , Kim Dae Woo
Published: November 2024

Objectives. This study evaluates the enduring efficacy and patient satisfaction of dupilumab with interdose interval adjustments based on the Sino-Nasal Outcome Test (SNOT-22) in chronic rhinosinusitis with nasal polyps (CRSwNP).Methods. A retrospective analysis was conducted on 44 patients who had been treated with dupilumab for over 6 months. This study targeted individuals diagnosed with CRSwNP according to the 2020 edition of the European Position Paper on Rhinosinusitis and Nasal Polyps Criteria. The treatment involved an add-on dupilumab regimen, where the interdose interval was adjusted based on the SNOT-22 scores. Dosage adjustments were made such that patients with initial SNOT-22 scores greater than 40 were tapered to a target level of 20 or less. Similarly, for patients with initial scores of 40 or less, the treatment aimed for an improvement of 50% or more. At each visit, the effectiveness of the treatment was evaluated using SNOT-22, nasal polyp scores (NPS), and a subjective satisfaction questionnaire adapted from the Treatment Satisfaction Questionnaire for Medication (TSQM v.1.4).Results. The adjustment of the interdose interval for dupilumab based on SNOT-22 scores demonstrated sustained improvements in patients’ subjective symptoms, satisfaction, and NPS. The mean (standard deviation) SNOT-22 scores significantly decreased from 46.04 (22.30) to 14.72 (13.66) over 6 months (P<0.001). Similarly, NPS scores improved from 3.20 (2.24) to 1.72 (1.46) within the same period (P<0.001). Satisfaction scores, ranging from 0 to 5, consistently remained above 3.5 for up to 6 months (P=0.166). Additionally, there was a significant correlation between the improvement in the nasal symptom domain of the SNOT-22 scores and higher satisfaction scores.Conclusion. Adjusting dupilumab dosing intervals based on SNOT-22 scores from the outset resulted in sustained efficacy and patient satisfaction in Korean patients with CRSwNP. This approach will meaningfully assist clinicians in determining the optimal dupilumab dosing interval.
Topographic and Geodetic Survey for Samarkand's Administrative Boundaries
Authors: D Obidova D. , O Khamdamova D.
Published: November 2024

General Background: Administrative and territorial boundary delineation is vital in the effective governance and economic planning of urban regions globally, with digital technologies increasingly integrated into these processes for accuracy and efficiency. Specific Background: In Uzbekistan, the city of Samarkand’s administrative boundaries are undergoing significant realignment as part of a broader initiative to incorporate strategic urban centers and enable digital land management across administrative zones. Knowledge Gap: Existing methods lack precise integration with digital geospatial frameworks, leaving a gap in high-resolution topographic data essential for clear administrative delineation. Aims: This study seeks to develop and apply an accurate, digitally supported methodology for determining the boundaries of Samarkand's administrative units using advanced geodetic and topographic techniques. Results: By utilizing the CREDO DAT program, this study achieved precise boundary coordinates through the automated processing of survey points, and further analysis was conducted using the Panorama program for detailed map orientation. Novelty: This research presents a unique approach by integrating CREDO DAT with geospatial tools in administrative boundary demarcation, enabling accurate and reproducible results that surpass traditional methods in efficiency and scalability. Implications: The findings support the strategic planning of Samarkand’s infrastructure and resource allocation while also laying the groundwork for applying similar methodologies in other urban regions, advancing Uzbekistan’s digital transformation efforts in land management.Highlights:

Digital tools enhance accuracy in administrative boundary mapping.
CREDO DAT and Panorama software streamline data processing for precise mapping.
This method supports effective urban planning and resource management in Samarkand.

Keywords: Administrative Zones, Border, Territory, District, City
The Geysers Is a Unique Geothermal Resource Presenting Equally Unique Challenges to Drillers
Authors: Rassenfoss Stephen
Published: November 2024

_

For drillers, The Geysers is a unique sort of hell.

It is one of the only places on Earth where a shallow well can reach a highly fractured reservoir so hot that it only produces steam.

That steam powers 18 power plants generating 835 MW of electricity, making this 45-square-mile area the world’s most prolific geothermal power producer.

High drilling costs there also stand out. Drilling a well requires 60 days or so and generates a lot of damaged drill bits and drillpipe.

The drilling rigs have the size and power of modern onshore rigs, but a close look reveals there’s no topdrive. Below the rig floor there is a rotary table, known as a Kelly drive because it can spin drilling pipe without being in the line of fire of the steam flowing out when running slotted casing into the steam-production zone.

When they get to that zone, they switch from drilling fluid and mud to injecting a high-pressure stream of air because of the enormous fluid losses anticipated when they reach that highly fractured level.

A drill bit that lasts 500 ft in this harsh, highly fractured rock has had a long run.

And the rugged terrain—mountains to a Texan but hills to a Californian—makes this a hard place to move a rig.

“The Geysers is its own animal, for sure,” said Sam Noynaert, a Texas A&M professor who was a key member of a team of drilling experts and scientists that drilled a well in The Geysers to test if faster drilling methods from the oil business could work there.

The two upper sections went pretty well, considering. As they went deeper, they repeatedly had to deal with severe fluid losses. Still, they had shaved nearly 6 days off the average drilling time.

But when they reached the highly fractured steam-producing payzone and their drilling method changed to air drilling, things got worse with drill bits failing after runs as short as 21 ft.

As a Geysers drilling paper presented at the Stanford Geothermal Workshop earlier this year delicately put it: “The air section proved to be more challenging.”

The Blob

The Geysers has a long history. The heat source is “a large blob of silica-rich magma (which) forced its way through Earth’s crust beneath the Coast Range,” according to the description of an image from NASA.

That flow about 1.3 million years ago from deep within the earth heated the overburden, making the rock brittle and prone to fracturing. Over time, water seeped into those hot fissures, creating hot springs that were awed by Native Americans and later attracted tourists to a nearby resort hotel.

By the 1960s drillers were tapping the steam in those payzones for commercial power generation, which peaked at 2,000 MW in 1987. It declined from there as steam production depleted the reservoir. Eventually, the output was stabilized at its current level by injecting water from sewage-treatment plants into the production zone.
Technology Focus: Drilling and Completion Fluids (November 2024)
Authors: Carpenter Chris
Published: November 2024

This year’s primary selections for the Drilling and Completion Fluids Technology Focus reflect now-well-established industrywide emphases on machine learning (ML), automation, and the achievement of successful drilling of CO2 storage wells. Enhanced methods of modeling and monitoring allow time and cost savings while surpassing safety goals and furthering efforts to optimize CO2 storage.

Paper OTC 35433 discusses a study centered on accurate gel-strength estimation. The authors leverage ML techniques, particularly the use of artificial neural networks, to develop predictive models for forecasting the gel strength of synthetic oil-based mud systems at both 10-second and 10-minute intervals, surpassing the precision and speed of techniques based on traditional rotational viscometers.

In a similar vein, paper SPE 216322 seeks to bypass traditional manual methods of monitoring drilling fluids, its authors describing a novel online system that measures 10 key parameters continuously. They write that the system has been field-trialed across 200 wells with results that highlight the system’s reliability, with continuous operation for over 125 days.

Finally, paper SPE 217711 involves evaluating the effects of an influx of CO2 into drilling fluids, a key task in the drilling of CO2 storage wells. Concentrating on oil-based drilling fluid, the presented study describes the development and integration of models for properties of drilling-fluid/CO2 mixtures into an existing software suite.

Recommended-reading papers include an investigation of the use of microwave power in recovering oil from contaminated drill cuttings, reduction of the carbon footprint of drilling fluids, and sedimentation behavior of particles in fibrous sweep fluids. As always, the long-sighted ambition of such research, and the skill applied in its pursuit, reflects the commitment to excellence embodied by the authors of technical papers presented at SPE conferences.

Recommended additional reading at OnePetro: www.onepetro.org.

SPE 217140 Microwave-Assisted Technique for Oil Recovery From Oily Sludge Shale Drilled Cuttings by A. Agi, Universiti Malaysia Pahang, et al.

OTC 34667 Successful Decarbonization of Drilling Fluids by Using Highly Efficient Technology and Reduced Chemical Usage, Logistics, and Casing Sections by Gerardo Jardinez, Pemex, et al.

SPE 218631 Application of Machine-Learning Method for Modeling Settling Behavior of a Spherical Particle in Fibrous Drilling Fluids by R.M. Elgaddafi, Australian University, et al.
Real-Time Monitoring and Control System Enhances Drilling-Fluid Management
Authors: Carpenter Chris
Published: November 2024

_

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 216322, “Next-Generation Drilling-Fluid Management: Real-Time Monitoring and Autonomous Control,” by Zhicai Zhang, Rached M. Rached, SPE, and Yunbo Xun, Sinopec, et al. The paper has not been peer reviewed.

_

Accurate measurement and control of drilling-fluid properties are crucial for safe and successful drilling operations. Traditional manual methods are slow and require significant manpower, underscoring the need for real-time monitoring. This paper highlights a new online system for monitoring drilling fluids, enabling intelligent control of drilling-fluid performance. The online monitoring system improves drilling-industry safety and success by measuring properties of drilling fluids in an accurate, timely, and automated matter.

Introduction

The primary objectives of this project are to develop an innovative online system for monitoring drilling fluids with a focus on facilitating intelligent control of drilling-fluid performance. The system aims at measuring 10 key parameters continuously, including apparent viscosity, plastic viscosity, yield point, density, pH, and ion concentrations. By incorporating online, real-time, continuous monitoring capabilities, the system offers several advantages, including improved data quality and frequency, reduced on-site labor requirements, and a corresponding decrease in associated health and safety hazards.

System Description

Overview of the Online Drilling-Fluid-Monitoring System.

The online drilling-fluid-monitoring system is available in four distinct configurations: land modular, land skid-mounted, offshore cabin, and indoor small modular, providing customization options to meet specific space requirements. The system is designed to measure 10 crucial parameters essential for drilling operations. These include rheology factors, density, pH, sulfur ion content, and chloride ion content.

Density and rheology measurements are performed at a 1-Hz sampling rate, offering near-continuous monitoring. The system is capable of operating within an ambient temperature range from –35 to 50°C, and the testing temperature can be adjusted between 4 and 80°C.

Enabled by real-time data transmission, the system allows for the online, real-time monitoring of drilling-fluid properties. The system has proven its utility extensively, with more than 30 sets having been deployed successfully across more than 200 wells.

Ideally, the monitoring system is positioned near the circulation tank to enable efficient fluid transfer (Fig. 1a). When space near the circulation tank is limited, an alternative placement can be on the opposite side of the blowout-prevention pipeline (Fig. 1b). However, this alternative may lead to a slight delay in data because of extended circulation times.
Company R&D: Does It Add Value to the Bottom Line?
Authors: Clementz David M.
Published: November 2024

Company R&D can add value to the bottom line if it is focused. Every project needs a goal. The goals can be long-term, but they need to be present to focus the energy and resources on solving problems that matter. To achieve this focus, companies must develop strategies that take advantage of their technical competence. They must design processes that will link their internal capabilities to the needs of their internal market and also to external capabilities. They must build an organization around those processes that will enable it to function efficiently and effectively. When this is complete, they can fill the organization with the resources needed to meet the current and future demands.

Background

Recent cutbacks in R&D spending in the petroleum industry have caused many people to ask, "Why?" There have been many articles, letters to editors, and symposia dedicated to this topic in the last few years. They seem to be asking similar questions. Why, in an industry that is dependent on technology for its future, would there be such a significant drop in investment for R&D? Is R&D "under siege" from the tyranny of short-sighted business-unit managers? Is it "easy pickings" for the cost cutters? Is the industry so mature that it does not need much R&D? Or, is there a natural evolution under way toward a more focused, more commercially relevant form of R&D? In other words, is the sun rising or setting on R&D in the petroleum industry?

Some have suggested that we are witnessing the end of an era for corporate scientific research laboratories in the U.S. The petroleum industry is not immune to these changes. However, the premise of this article is that a new era is dawning. Company R&D (i.e., that which is internal to an oil or gas company) can add value if we can define our expectations for it and for the measures of that value. The industry still needs R&D but is demanding it in a new form. Company R&D has a future if it can adapt and change.
Quantifying key drivers of marine pyrite burial flux and isotopic composition
Authors: Mertens Cornelia , Paradis Sarah , Hemingway Jordon
Published: November 2024

Pyrite formation and burial in marine sediments decreases atmospheric CO2 and increases O2 levels. However, the sedimentological conditions that control pyrite burial remain poorly constrained, precluding quantitative reconstructions of sulphur cycle regulation on atmospheric compositions. Building on updated understanding of pyrite isotope dynamics, here we provide mechanistic insight by developing a non-dimensional diagenetic model that extracts the natural variables governing pyrite formation rates and sulphur isotopic compositions (δ34S values). Both properties are controlled by the local ratios of organic carbon content to sulphate concentration and organic carbon reactivity to sedimentation rate; formation rate is additionally sensitive to reactive iron delivery. Using only globally interpolated boundary values as inputs, our model accurately predicts signals recorded in a validation dataset of 216 sediment cores from diverse environmental settings across the modern ocean. Extrapolating this, we estimate a global pyrite burial flux of 7.0 × 10^12 mol S yr^-1 (sensitivity test range: 2.5 × 10^12 to 19.0 × 10^12 mol S yr^-1) with a weighted-average δ34S value of -4 ‰ VCDT (range: -8 to +3 ‰ VCDT). This flux is substantially larger than that of terrestrial pyrite oxidation (1.3 × 10^12 mol S yr^-1), indicating that the sulphur cycle is currently not in steady state, but rather described by net pyrite burial and thus atmospheric O2 accumulation. Finally, we utilise this model framework to invert the geologic pyrite δ34S record and assess changes in sedimentological properties and pyrite burial flux throughout the Phanerozoic Eon.
IGFBP3-mediated M2 Macrophage Polarization Enhances Resistance to Rosiglitazone and Cisplatin in Breast Cancer
Authors: Gao Chunyi , Li Gang , Hu Tianhui , Guohua Wang
Published: November 2024

Background
Rosiglitazone (PPARγ agonist, RGZ) combined with chemotherapy drugs has proven effective in treating clinical breast cancer patients. However, the underlying targets and resistance mechanisms remain unclear, posing challenges in maintaining long-term efficacy. This study aimed to investigate the mechanisms of RGZ in macrophage polarization and evaluate its effects within the TME.
Methods
In vivo experiments were conducted using a patient-derived xenograft (PDX) nude mouse model resistant to chemotherapy, which simulates the clinical immune microenvironment. In vitro, the Thp-1 human monocytic cell line was induced to differentiate into macrophages and cocultured with MDA-MB-468 breast cancer cells. The effects of PPARγ agonists on the drug resistance of breast cancer cells in a coculture model were explored.
Results
An increase in M2 macrophages was observed in combination-resistant mice, with PPARγ activation by RGZ inducing macrophage differentiation toward the M2 phenotype. Knockdown of IGFBP3 in macrophages alleviated breast cancer cell resistance in the microenvironment by reversing polarization.
Conclusion
Our study revealed that targeting macrophage polarization through IGFBP3 can reverse the effects of PPARγ on macrophage polarization, promote cancer cell apoptosis and collectively reverse the resistance of tumor cells to combination therapy. These findings provide a new theoretical basis for anti-breast cancer treatment.
The Health Promoting Sports Coach: Theoretical background and practical guidance
Authors: Tezier Benjamin , Barros Kévin , Geidne Susanna , Bardid Farid , Grieco Spartaco , Johnson Stacey , Kokko Sami , Lambe Barry , Lefebvre Arthur , Lane Aoife , Ooms Linda , Seghers Jan , Sevdalis Vassilis , Whiting Stephen , Vuillemin Anne , Hoye Aurélie Van
Published: November 2024

The organised sport setting is a key context for health promotion, but it can also be associated with risky behaviours. Sports coaches play a crucial role in supporting the health of sport participants but often lack the resources and support to do so. This paper proposes a guide to help coaches become health promoters by defining their key actions in line with the Health Promoting Sports Club model. An embedded mixed-method study with a QUAL (qual) design was used, where 15 experts took part in 5 meetings and 299 coaches provided input through an online survey. Four steps were carried out: (1) defining the health-promoting sports coach and key action principles, (2) co-constructing progression stages using the settings-based approach, (3) identifying key actions for promoting health in different coaching moments, and (4) developing long-term intervention components. A definition of the health-promoting sports coach was produced, and eight key action principles have been identified, divided into three dimensions: connection with the system, adoption of a coaching philosophy, and focus on participants. Five stages of progression for integrating health promotion into coaching have been established, ranging from risk prevention to a global approach involving the entire sports system. Specific actions for each moment of coaching (before, during and after training, and competition) have been determined, such as ‘monitoring the physical, mental and social health of participants’ or ‘ensuring a cool-down, stretching, shower and proper eating after competition’. Finally, long-term intervention components to support the implementation of these actions in practice have been developed based on what coaches are already doing, the skills they possess and the five stages of progression. This paper enabled the development of a guide to help sports coaches promote health by identifying concrete actions and short- and long-term interventions, whilst making links with the health promoting sports club model. It broadens the scope of coaching by incorporating health principles, while emphasising the need to adapt to the environment and context of the club. This work calls for future research to test the effectiveness and feasibility of these approaches in various sporting environments.
Electrophysiological versus anatomical identification of midline myelotomy in intramedullary spinal cord tumors
Authors: Ashry Ahmed Hamdy , Gabr Mohamed , Ali Mohammed F.A
Published: November 2024

Background
In this retrospective study we evaluated the utility of neurophysiological cord mapping in accurate identification of the midline for safe resection of intramedullary spinal cord tumors. We also determined the correlation between the anatomical and physiological midline. Eighteen patients with intramedullary spinal cord tumors underwent surgical resection at 2021–2024. We attempted to identify the midline for myelotomy using anatomical landmarks. We used phase reversal technique for dorsal cord mapping to confirm or correct the midline. Patients` demographics, surgical details and clinical outcomes were recorded. The relation between the anatomical and physiological midline was analyzed statistically.
Results
Anatomical identification of the midline failed in 6 cases necessitating neurophysiological mapping. Correction of the anatomical midline by mapping was done in 3 patients. Postoperative assessment 3 months after surgery showed improvement in 6 of 9 patients with preoperative somatosensory deficits, with no new worsening neurological functions observed.
Conclusion
Intraoperative neurophysiological mapping using phase reversal technique is an essential tool to accurately locate the midline during resections of intramedullary spinal cord tumors particularly in cases with ambiguous anatomical landmarks.
Dynamic and calving response of a major Greenland ice stream to a propagating subglacial flood
Authors: Wehrlé Adrien , Lüthi Martin , Kneib-Walter Andrea , Nap Ana , Rousseau Hugo , Jouvet Guillaume , Walter Fabian
Published: November 2024

Outlet glaciers are the main arteries of the Greenland Ice Sheet transporting ice from the interior towards the ocean. Understanding their dynamics is crucial in the context of accelerating Arctic warming. While glacier flow dynamics is monitored with satellites, important rapid processes remain undetected at intervals of days between acquisitions. The short-term dynamics of fast flowing glaciers therefore remains poorly understood and insufficiently constrained in
numerical models.

Here, we use high-rate field observations on Greenland's fastest ice stream, Sermeq Kujalleq in Kangia (SKK), to characterize its response to the drainage of two surface lakes. The ensuing subglacial flood caused a surface speedup pulse that efficiently propagated towards the terminus where it triggered large calving events. This full process chain has so far not been documented. Using this large and abrupt disturbance as a full-scale natural experiment, we investigate SKK's dynamic sensitivity in unprecedented detail. The undamped and fast-pace nature of the speedup pulse, together with the instantaneous response of the surrounding ice margins, indicate strong coupling within the ice stream system. Our results highlight how inland areas can accommodate large disturbances and efficiently propagate them downstream to trigger irreversible changes at dynamic glacier termini potentially prone to destabilization.
DNAJC7 expression in rat brain after a single cortical injury and in human ALS-affected brain cortex and hippocampus
Authors: Volkening Kathryn , Donison Neil , Hintermayer Matthew A , Palik Jacqueline , Fisher Jessica , Subramaniam Maegha , Duennwald Martin , Strong Michael J.
Published: November 2024

DNAJC7 is a highly conserved J-domain protein that recently was determined to have mutations in amyotrophic lateral sclerosis (ALS). The expression of DNAJC7 in the nervous system is not well known, nor is if DNAJC7 has a role in injury. Here we characterize the expression of DNAJC7 in a rat model of traumatic brain injury in which the temporal cascade of events leading to tau pathology has been mapped. DNAJC7 expression increases after injury, with expression in neurons, astrocytes and microglia. After injury, expression selectively decreases in granular cells of CA2 in the hippocampus, and localization in neurons in the cortex moves from perikaryal into cell processes. DNAJC7 also localizes to phospho-Thr175 tau and TNT1 positive (exposed PAD) tau but dissociates rapidly from PAD exposed tau suggesting that structural change may play a role in its release. In vitro a phospho-Thr175 tau mimic (Thr175Asp) failed to immunoprecipitate DNAJC7, while phospho-null (Thr175Ala) and wildtype tau did, suggesting this phosphoresidue is likely less important for dissociation than the subsequent structural change in tau. Human brain (cortex and hippocampus from neuropathologically normal controls, ALS and ALS with cognitive impairment) was also examined for DNAJC7 expression and tau interaction. DNAJC7 expression was altered in all ALS cases with localization in cell processes, and nuclear expression in oligodendrocytes, while in only ALS cases with cognitive impairment many additional large arborized cells in the cortex and hippocampus appear to have increased DNAJC7 expression in cell processes. Wasteosomes (corpora amylacea) were also DNAJC7 positive. Taken together, DNAJC7 expression in the brain is widespread, is altered in a rat model of brain injury and in ALS and ALSci, and its dissociation from tau appears to be during or shortly after PAD exposure.
Development, Rasch Validation, and Confirmatory Factor Analysis of the Individual's Social Responsibility Scale
Authors: Almubaddel Abdulmohsen
Published: November 2024

Background: This study aimed to systematically develop and validate a measurement instrument for individual’s social responsibility (ISRS). It seeks to ensure robust psychometric properties and construct validity through Rasch model and confirmatory factor analysis (CFA).
Methods: This study employed a cross-sectional design and collected questionnaire responses from 812 individuals in Saudi Arabia through a random sample. The study collected data using demographic variables and the Arabic-language ISRS (16-items), developed and validated through Rasch analysis and CFA using the Wisntep (version 5.3.2) and AMOS (version 23) software, respectively.
The CFA results demonstrated a good fit for the model, with indices such as RMSEA (0.067) falling within the recommended range and CFI score of 0.96, exceeding the threshold of >0.95. Rasch analysis confirmed the reliability of the ISRS items and subscales, with adjustments made to the Likert scale for enhanced precision, based on the results of ISRS1, ISRS4-8, ISRS14, and ISRS16. Multidimensionality assessments revealed significant variations in explained variances, with participant hierarchy analyses supporting efficient test item targeting.
This study emphasizes the significance of community engagement, personal commitment, and social concern in fostering individual social responsibility among Saudi Arabian individuals, providing valuable insights for future research and interventions aimed at promoting social responsibility in the region.
A Nomogram for Predicting Malignancy in Small and Non-parallel BI-RADS 4A Breast Lesions: A Novel Approach for Risk Stratification and Clinical Decision Support
Authors: Li Qin , Sun Xiaowei , Deng Jing , Zhou Wenbin , Pan Hong , Zhang Kai
Published: November 2024

Purpose
Breast Imaging Reporting and Data System (BI-RADS) 4A breast lesions are often confusing for surgeons due to high false-positive outcomes. This study was conducted to analyze the factors of small and non-parallel BI-RADS 4A breast lesions and developed a predictive model to stratify the malignancy risk.
Methods
For this retrospective study, 282 patients were recruited in the First Affiliated Hospital of Nanjing Medical University from January 2020 to December 2023. Logistic regression analysis was used to identify risk factors and develop a predictive model to differentiate between benign and malignant BI-RADS 4A breast lesions. The effectiveness of the model was assessed by the receiver operating characteristic (ROC) curve and the decision curve analysis (DCA).
Results
The proportion of malignant tumors was 20.6% (58/282) in this study. A diagnostic model compromised age, menopausal status, and margin was built and shown as a nomogram. The area under the ROC curve was 0.747 and 0.741 in the training and test cohort, respectively. DCA demonstrated that the model could achieve benefits for patients. Moreover, we stratified the breast lesions into low-, medium- and high-risk groups according to the malignancy risk calculated by the model. Only 10% (5/50) and 4.8% (1/21) were malignant in the low-risk group in the training cohort and test cohort.
Transcriptional Regulation of Protein Synthesis by Mediator Kinase Represents a Therapeutic Vulnerability in MYC-driven Medulloblastoma
Authors: Vibhakar Rajeev , Wang Dong , Ritz Caitlin , Pierce Angela , Veo Bethany , Luo Yuhuan , Brunt Breauna , Dahl Nathan , Suresh Ammu , Serkova Natalie , Venkataraman Sujatha , Danis Etienne , Kuś Kamil , Mazan Milena , Rzymski Tomasz
Published: November 2024

MYC-driven medulloblastoma (MB) is a highly aggressive cancer type with poor prognosis and limited treatment options. Through CRISPR-Cas9 screening of MB cell lines, we identified the Mediator-associated kinase CDK8 as a critical regulator of MYC-driven MB. Loss of CDK8 substantially reduces MYC expression and induces pronounced transcriptional changes, consequently inhibiting MB growth and suppressing monosome assembly, resulting in decreased ribosome biogenesis and protein synthesis. Mechanistically, CDK8 regulates the occupancy of RNA polymerase II at specific chromatin loci, facilitating an epigenetic alteration that promotes the transcriptional regulation of ribosomal genes. Targeting CDK8 effectively diminishes the stem-like neoplastic cells characterized by hyperactive ribosome biogenesis. Furthermore, we demonstrated that the combined inhibition of CDK8 and mTOR synergizes to optimize therapeutic outcomes in vivo and in vivo. Overall, our findings establish a connection between CDK8-mediated transcriptional regulation and mRNA translation, suggesting a promising new therapeutic approach that targets the protein synthesis for MYC-driven MB.
Understanding Clean-Energy Supply Chains: A US Perspective
Authors: Dvorkin Yury , Yao Boyu , Jeong Hannah , Mehrtash Mahdi , Ockerman Daniel , Allan Bentley
Published: November 2024

This paper examines supply chain conditions which affect the US clean energy goals. By focusing on critical raw materials for wind, solar photovoltaic, and lithium-ion battery storage technologies, we develop an optimization model to simulate supply chain conditions through 2050. The model incorporates historical growth rates from the last mineral production supercycle and critical raw material trade flows to estimate future availability. Our findings reveal that under the current trade strategy and production growth, the US may achieve only 65% of its clean energy goals, with nickel, silicon, and rare earth elements identified as key bottlenecks. This paper emphasizes that meeting clean energy goals requires not only enhancing domestic production and manufacturing capabilities for these critical materials but also strengthening international cooperation and adopting mitigation strategies to address supply chain constraints.
Aqueous secondary formation substantially contributes to organophosphate esters in aerosols
Authors: Zhang Gan , Lv Shaojun , Tian Lele , Zhao Shizhen , Jones Kevin , Chen Duohong , ZHONG Guangcai , Li Jun , Xu Buqing , Peng Ping'an
Published: November 2024

Chemicals of emerging concern (CECs), like organophosphate esters (OPEs), are toxic substances threatening human/wildlife health. Yet the atmospheric transformation of CECs remains poorly understood. Here we combine field measurements and partitioning models to test the hypothesis that the secondary formation of OPEs could be enhanced by heterogenous processes in aerosols. We found that hydrophobic OPEs are absorbed favorably into the organic phase, whereas hydrophilic OPEs preferably partition into the aqueous phase. We provide field evidence that enhanced aqueous secondary formation of OPEs occurs in winter, and the magnitude is strongly dependent on aerosol water content. We suggest that dissolved inorganic salts and transitional metals in aerosols impact positively on the formation of particle-bound hydrophilic OPEs, by facilitating their aqueous partitioning and/or oxidation. Our findings highlight the important role of aqueous oxidation chemistry for the fate of CECs in the atmosphere, urging for a better consideration of transformation products in future risk assessment and chemicals management.
Studierendenpartizipation in der Studiengangsentwicklung
Authors: Köstler Verena , Krinninger Jonas , Gallenmüller Martina , Birnkammerer Hannes , Mägdefrau Jutta
Published: November 2024

Die Frage nach der Partizipation von Studierenden an Hochschulen ist nicht nur auf der Ebene von Lehrveranstaltungen, sondern auch für die Qualitätssicherung und -entwicklung auf Studiengangsebene zentral. Der Beitrag betont ausgehend von Befunden der Hochschulforschung zu „student voice“ die Notwendigkeit, Studierende systematisch und frühzeitig in Weiterentwicklungsprozesse von Studiengängen einzubinden. Ein dafür entwickeltes datengestütztes und als OER verfügbares Verfahren wird methodisch und mit handlungsleitenden Empfehlungen vorgestellt sowie im Hinblick auf die nachhaltige Implementation in Hochschulentwicklungsprozesse diskutiert.
Kemampuan Metaphorical Thinking dalam Menyelesaikan Soal HOTS SPLDV ditinjau Tipe Gaya Belajar
Authors: Kowi Mohamad Saiful , Fakhriyana Dina
Published: November 2024

This research aims to analyze students' metaphorical thinking abilities in solving HOTS questions on SPLDV material in terms of auditory, visual, and kinesthetic learning styles. This type of research is descriptive with a qualitative approach. The results of the research show that: 1) the metaphorical thinking abilities of auditory-type students are capable and good at the connect, relate, and explore stages. The transform and analyze stages were quite good. This can be seen from the condition of students who still experience doubts in explaining and make mistakes in solving problems. Students are not yet able to perform well at the experience stage; 2) the metaphorical thinking ability of visual-type students is capable and good at the relate and explore stages. The connect, analyze, and transform stages were quite good. This can be seen from the condition of students who still have not written down complete information and make mistakes in solving problems. Students are not yet able to perform well at the experience stage; 3) the metaphorical thinking ability of kinesthetic type students is capable and good at the relate and transform stages. The connect, explore, and analyze stages were quite good. This can be seen from the condition of students who still experience doubts in explaining and make mistakes in solving problems. Kinesthetic-type students can do quite well at the experience stage.
Impact of Instagram visual content on eWOM for Sharia hotels in Indonesia
Authors: Alam Azhar , Sherly Rusiana Annisa , Rahmawati Estina , Isman
Published: November 2024

The primary aim of this research is to investigate the effects of Advertisement Presentation of Contents (APC) and Advertisement Visual Types (AVT) on the eWOM of Sharia hotels. A quantitative approach was utilized, analyzing 202 Instagram posts from five Indonesian Sharia hotels between June and November 2023. The methodology involved the Structural Equation Modeling (SEM) with Partial Least Squares (PLS) analysis using Smart PLS software. The results revealed that visual content types, such as photos, videos, and reels, significantly enhance consumer attraction, with a path coefficient of 0.372 and a p-value of 0.000, indicating a strong positive influence. In contrast, hashtags and links showed no significant effect, with a path coefficient of -0.838 and a p-value of 0.000. The R-squared adjusted value of 0.208 indicates that the independent variables explain 20% of the variance in the dependent variable. The AVT’s influence on eWOM is at a high level (f-squared = 0.042). These findings suggest that Sharia hotels should prioritize creating high-quality visual content to enhance their social media marketing strategies. The study concludes that effective visual content on Instagram can enhance eWOM and improve consumer perceptions of Sharia hotels, enabling them to compete with conventional hotels. These findings provide valuable insights for Sharia hotel marketers to optimize their social media strategies, emphasizing the importance of visual content over textual elements like hashtags and links.
A rare case rupture of sinus of Valsalva aneurysm in a peripheral hospital
Authors: Nugraha Naufal Fakhri , Hanifah Hilmi Nadya , Nadiah Za , Namirah Nabila Azka , Panggabean Abednego
Published: November 2024

Background: The sinus of Valsalva aneurysm (SVA) is an uncommon cardiac abnormality that may be either congenital or acquired.
Case: In this case we describe a 73-year-old man who complained of acute shortness of breath. Echocardiography showed rupturing of a sinus Valsalva aneurysm into the right ventricle with ventricular septal defect/rupture diagnoses in a peripheral hospital far from a reference hospital.
Conclusion: Echocardiography can aid in distinguishing between different diagnoses and serve as a catalyst for more exploration into the underlying cause. This can enhance the likelihood of early detection of an SVA and enable the implementation of an effective management strategy.
Clinical profile, management strategy, and outcomes of patients with prosthetic valve thrombosis
Authors: Khan Waqar , Younus Arsalan , Ansari Muhammad Imran , Shah Jehangir Ali , Naz Mariam , Khowaja Raheela , Khowaja Aamir , Ali Taimur Asif , Khursheed Munawar , Saghir Tahir
Published: November 2024

Background: Prosthetic valve thrombosis (PVT) is a severe complication following prosthetic heart valve replacement, particularly in inadequately anticoagulated patients. Primary treatment options include intensive anticoagulation therapy, thrombolytic treatment (TT), and emergency surgery. This study aims to evaluate the clinical profile, management strategies, and short-term outcomes of patients with PVT.
Methodology: Consecutive patients with PVT presenting to the emergency department of a tertiary care cardiac center were included in this study. Responses to treatment, hospital outcomes, and 30-day outcomes post-treatment were observed.
Results: A total of 75 patients were analyzed, with a male predominance (50.7%) and a mean age of 39.5 ± 12.3 years. Bi-leaflet prosthetic valves were most common (96.0%), 54 (72.0%) had prosthetic mitral valve and 10 (13.3%) had prosthetic both mitral and aortic valves. Atrial fibrillation was present in 25.3% of cases. Treatment predominantly involved streptokinase (74.7%), followed by heparin (37.3%) and VKA (9.3%). Clinical success was achieved in 84.0% of cases, while 12.0% experienced clinical failure, including severe complications such as irreversible neurologic damage (1.3%) and bleeding (2.8%). The 30-day mortality rate was 12.0%, with recurring PVT and bleeding/embolic complications each in 1.5% of cases.
Conclusion: Treatment of PVT with streptokinase, heparin, and VKA demonstrates efficacy, with a substantial proportion of patients achieving complete clinical success. However, the study highlights concerning outcomes, including clinical failure and severe complications. These findings underscore the importance of carefully balancing thrombolytic and anticoagulant therapies to mitigate potential adverse events.
MEANS OF EXPRESSIVENESS IN AMERICAN POLITICAL DISCOURSE (BASED ON DONALD J. TRUMP’S SPEECHES AT THE TV DEBATES OF 2020)
Authors:   St. Petersburg State University, Katargulov Dmitrii N.
Published: November 2024

This article examines the means of expressiveness used by the 45th President of the United States in the television election debates of 2020. We studied transcripts of two TV debates, analyzed the functions of the expressive means used and classified them according to linguistic levels. Based on the results of the study, we identified the most frequent means of expressiveness, such as metaphors, idioms, euphemisms and lexical repetition.