bluuebunny/crossref_metadata_2025 huggingface dataset:
Family Matters: Dual Network Embeddedness, Resource Acquisition, and Entrepreneurial Success of Small Tourism Firms in Rural China
Authors: Li Qiucheng , Zhang Huanzhou , Wu Mao-Ying , Wall Geoffrey , Ying Tianyu
Published: September 2021

Small tourism firms (STFs) established and operated by local families can be an engine of sustainable rural tourism. This paper stresses the intimate intertwining of family and business in rural STFs and conceptualizes their entrepreneurial success as a combination of business performance and family well-being. Integrating the resource-based view and network embeddedness theory, relationships among the STF owners’ dual social networks (family and industry networks), entrepreneurial resource acquisition, and entrepreneurial success are proposed and tested with a sample of 276 STFs in rural China. The empirical analyses reveal that (1) compared with tangible and knowledge-based resources, the owners’ acquisition of psychic resources has the strongest effect on entrepreneurial success; and (2) although industry networks provide more diverse access to entrepreneurial resources, family networks are superior in facilitating psychic resource acquisition, thus are especially important to the entrepreneurial success of rural STFs. Theoretical and practical implications are discussed.
You Play a Sport, Right? A Persistent and Pernicious Intersectional Bias in Categorization of Students vs. Student-Athletes
Authors: Higginbotham Gerald D. , Shropshire Jessica , Johnson Kerri L.
Published: September 2021

Black male students on college campuses report being frequently misperceived as student-athletes. Across three studies, we tested the role of perceivers’ racial and gendered biases in categorization of Black and White students and student-athletes and the subsequent evaluative consequences. Participants viewed faces of actual Black and White male and female undergraduates who were either non-athlete students or student- athletes and made binary judgments about whether the undergraduate was a student or an athlete. We found an overall bias to judge Black male undergraduates to be student-athletes, driven by Black male students being more likely to be misperceived as student-athletes than White male students. Furthermore, male targets perceived to be student-athletes were rated lower on academic ability (Studies 2 and 3). In contrast, we found an overall bias to judge female undergraduates as students. Implications for how perceiver bias plays a dual role in negatively affecting academic climates for underrepresented groups are discussed.
Foucault and fugitive study
Authors: Means Alexander
Published: September 2021

Michel Foucault was one of the 20th century’s great practitioners of study. Time in the archives and library, teaching, reading, thinking, and writing were all integrated aspects of his tireless labor to find lines of escape out of the confines of Western humanism and totalizing approaches to power and history. Drawing on Foucault’s lectures at the Collège de France and the work of James Bernauer, this article discusses Foucault’s mode of study as a practice of freedom. It then mobilizes Foucault’s analyses of biopolitics and neoliberal reason to address new enclosures of academic labor that push against study within the university. The article argues that Foucault was not able to anticipate how the biopolitical horizon would become ever-more dependent on extraction, including from the value generated by academic labor. It then draws on ideas of fugitivity and undercommons to supplement Foucault’s study as a mode of resistance.
L1 phonological effects on L2 (non-)naïve perception: A cross-language investigation of the oral–nasal vowel contrast in Brazilian Portuguese
Authors: Martinez Ruth Maria , Goad Heather , Dow Michael
Published: September 2021

Feature-based approaches to acquisition principally focus on second language (L2) learners’ ability to perceive non-native consonants when the features required are either contrastively present or entirely absent from the first language (L1) grammar. As features may function contrastively or allophonically in the consonant and/or vowel systems of a language, we expand the scope of this research to address whether features that function contrastively in the L1 vowel system can be recombined to yield new vowels in the L2; whether features that play a contrastive role in the L1 consonant system can be reassigned to build new vowels in the L2; and whether L1 allophonic features can be ‘elevated’ to contrastive status in the L2. We examine perception of the oral–nasal contrast in Brazilian Portuguese listeners from French, English, Caribbean Spanish, and non-Caribbean Spanish backgrounds, languages that differ in the status assigned to [nasal] in their vowel systems. An AXB discrimination task revealed that, although all language groups succeeded in perceiving the non-naïve contrast /e/–/ẽ/ due to their previous exposure to Québec French while living in Montréal, Canada, only French and Caribbean Spanish speakers succeeded in discriminating the naïve contrast /i/–/ĩ/. These findings suggest that feature redeployment at first exposure is only possible if the feature is contrastive in the L1 vowel system (French) or if the feature is allophonic but variably occurs in contrastive contexts in the L1 vowel system (Caribbean Spanish). With more exposure to a non-native contrast, however, feature redeployment from consonant to vowel systems was also supported, as was the possibility that allophonic features may be elevated to contrastive status in the L2.
BLADE turbo gradient- and spin-echo in the assessment of sinonasal lesions: a comprehensive comparison of image quality in readout-segmented echo-planar imaging
Authors: Geng Yue , Shi Yiqian , Chen Wei , Tang Zuohua , Zhang Zhongshuai , Zhou Kun , Sha Yan
Published: September 2021

Background

A two-dimensional turbo gradient-echo and spin-echo diffusion-weighted pulse sequence with a non-Cartesian BLADE trajectory (TGSE BLADE) can eliminate image artifacts and distortion with clinically acceptable scan times. This process has the potential to overcome the shortcomings of current diffusion-weighted imaging (DWI) techniques, especially in the sinonasal region.

Purpose

To investigate the feasibility of TGSE BLADE in the assessment of sinonasal lesions and compare the quality of TGSE BLADE with RESOLVE images both qualitatively and quantitatively.

Material and Methods

A total of 36 patients with sinonasal lesions were included in this prospective study. DW images acquired using TGSE BLADE and RESOLVE were performed with the same acquisition time. Two independent observers evaluated the qualitative parameters (overall image quality, lesion visibility, and geometric distortion) and quantitative parameters (geometric distortion ratio [GDR], signal-to-noise ratio [SNR], contrast, contrast-to-noise ratio [CNR], and apparent diffusion coefficient [ADC] value) of the two sequences.

Results

Qualitative assessment revealed that TGSE BLADE exhibited higher overall image quality ( P < 0.001) and lesion visibility ( P < 0.001) and less geometric distortion ( P < 0.001) than RESOLVE. Quantitative assessment showed that TGSE BLADE images exhibited higher contrast ( P < 0.001) and CNR ( P < 0.001) and lower GDR ( P < 0.05) and SNR ( P < 0.001) than RESOLVE images. The ADC value of TGSE BLADE was significantly lower than that of RESOLVE ( P < 0.05).

Conclusion

TGSE BLADE can reduce susceptibility artifacts and geometric distortion more than RESOLVE and appears to be a promising diffusion imaging sequence for the assessment of sinonasal lesions.
Anti-severe acute respiratory syndrome coronavirus-2 antibody responses following Pfizer-BioNTech vaccination in a patient with multiple sclerosis treated with ocrelizumab: a case report
Authors: Mado Hubert , Kubicka-Bączyk Katarzyna , Adamczyk-Sowa Monika
Published: September 2021

Patients with multiple sclerosis (MS) repeatedly receive therapies that cause B-lymphocyte depletion. This may lead to abnormal immune responses following coronavirus disease 2019 (COVID-19) vaccination, as has been suggested previously. We therefore evaluated post-vaccination immune responses in a patient with MS treated with ocrelizumab. The intervals between ocrelizumab infusions and vaccination were as recommended by the Section of Multiple Sclerosis and Neuroimmunology of the Polish Neurological Society. A reactive immune response was observed in this patient following vaccination. This suggests that appropriate intervals between ocrelizumab infusions and COVID-19 vaccinations may permit the generation of efficacious immune responses in patients receiving B-lymphocyte depleting therapies.
Mismatch repair deficiency in canine neoplasms
Authors: Inanaga Sakuya , Igase Masaya , Sakai Yusuke , Tanabe Mika , Shimonohara Nozomi , Itamoto Kazuhito , Nakaichi Munekazu , Mizuno Takuya
Published: September 2021

The DNA mismatch repair (MMR) system preserves genomic stability by identifying and repairing mismatched nucleotides in the DNA replication process. The dysfunction of the MMR system, also known as mismatch repair deficiency (dMMR), is implicated as a predictive biomarker for the efficacy of immune checkpoint blockade therapy regardless of the tumor type in humans. This study aimed to evaluate the immunolabeling of MMR proteins in canine tumors and to identify the types of tumors having dMMR. First, we performed immunohistochemistry in 8 different canine tumors (oral malignant melanoma, high-to-intermediate grade lymphoma, mast cell tumor, malignant mammary gland tumor, urothelial carcinoma, hepatocellular carcinoma, osteosarcoma, and hemangiosarcoma) with 15 samples each to analyze the immunolabeling of canine mismatch repair proteins (MSH2, MSH6, and MLH1) using anti-human monoclonal antibodies. We found that more than half of canine oral malignant melanoma (60%) and hepatocellular carcinoma (53%) samples and fewer of the other canine tumors had loss of immunolabeling in ≥1 MMR protein (ie, evidence of defective MMR proteins, based on the definition of dMMR in the humans). Antibodies against human MSH2, MSH6, and MLH1 were cross-reactive with the corresponding canine protein as confirmed using MMR gene knockout canine cell lines. Further studies are required to investigate the clinical outcomes in canine spontaneous tumors with dMMR to determine the potential for immune checkpoint blockade therapy for these tumor types.
Statistics and Genealogy: A Match Made in Heaven? The Forecasting and Inference Tool, an Application of the Central Limit Theorem in Genealogical Research
Authors: Alfano Vincenzo , Salerno Federica
Published: September 2021

Applications of econometrics and statistics are widely used as tools in many disciplines as a means to provide quantitative analysis to investigate hypotheses. Examples include economics, sociology, and cliometrics. While so far in a genealogy such an approach has not been attempted, in this exploratory work we suggest some possibilities for the application of such quantitative tools to the subject. In doing so, we introduce and discuss the Forecasting and Inference Tool, an application of this framework, and a tool that can help genealogists to be more productive in their fieldwork by estimating years of death, marriage, and birth.
Single-Staged Mastopexy With Augmentation: A Retrospective Review of 260 Patients in a Single Surgeon Practice
Authors: Dayal Nalin , Castellano Joseph
Published: September 2021

Mastopexy has become a widely popularized procedure across the country over the last 20 years. Women have seen the benefits of various forms of breast lifts to correct breast ptosis. While older teachings focused on mastopexy and augmentation as separate, staged procedures, many centers now perform both simultaneously. Our center primarily performs mastopexy procedures with simultaneous augmentation with implants, and we reviewed 260 patient charts to examine complications when compared to mastopexy alone. Complications reviewed include the following: hematoma formation, incision openings, and revision surgeries. Our data showed only minor rates of hematoma formation, incision openings, and revision surgeries with a negligible difference between the 2 groups. Patients in both groups overall had few surgical complications. Patients undergoing mastopexy with simultaneous augmentation had similar rates of complications when compared to patients with mastopexy alone. Many previously believed that simultaneous augmentation with mastopexy would place too much tension on the mastopexy incisions due to the rapid breast volume increase. However, with no significant changes in complications between the groups, it is clear that surgical technique and planning has improved to allow this to be a safely performed single-staged procedure. Overall, we had minimal complications and show that mastopexy with simultaneous augmentation is safe for patients who desire these procedures.
A Historical Review and Analysis of Impact Factors Across School Psychology Journals from 1977 to 2019
Authors: Floyd Randy G. , Lewis Emily K. , Walker Kelsey A. , McNicholas Patrick J. , Jones Kerry L.
Published: September 2021

School psychology journals yield hundreds of articles each year. As these journals are often evaluated based on the impact factors they produce, the aim of this study was to provide a historically complete record of the five impact factor values for the generalist school psychology journals that yield them. This study identified impact factors beginning in 1977, 20 years earlier than previously reported, and ending in 2019. Across all years and journals, the average Journal Impact Factor (JIF) was about 1.0, the average Immediacy Index was less than 0.4, the average 5-year Impact Factor was about 2.3, the average original CiteScore was 1.8, and the average new CiteScore was about 3.0. Increases in values were evident across time, and the highest recorded values across journals are held by the Journal of School Psychology (for the JIF, 5-year Impact Factor, and both CiteScore metrics) and School Psychology Review (for the Immediacy Index). Most impact factors, with the exception of the Immediacy Index, were moderately to highly correlated. The new CiteScore values were always the highest, and Immediacy Index values were always the lowest. School psychology has added journals to the list of those indexed by major databases, and these journals have increased their impact over time.
Facile fabrication and nanoscale assembly of polydopamine-functionalized, flexible chitosan films
Authors: Brooks Anne K , Imran Muhammad , Pradhan Sayantan , Broitman Jacob M , Yadavalli Vamsi K
Published: September 2021

Substrates that are simultaneously thin, strong, optically transparent, and biocompatible have diverse applications in a range of fundamental and applied fields. While nature-derived materials offer advantages of sustainability and inherent biocompatibility compared to synthetic polymers, their brittleness and swelling, as well as surface charge and chemical functionalization non-conducive to cell growth, can hinder widespread application. In this work, we discuss the fabrication and systematic characterization of polydopamine-coated chitosan thin films. Chitosan is a widely used, partially deacetylated form of chitin, derived from crustaceans and arthropods. Polydopamine (PDA) is derived from chemistries mimicking mussel foot adhesive proteins. A facile dip-coating process of thin and flexible, uncrosslinked chitosan films in aqueous dopamine solutions leads to dramatic changes in physical and chemical properties. We show how the PDA forms time-dependent assemblies on the film surfaces, affecting surface roughness, hydrophilicity, and mechanical strength. Coating the surface for even a few seconds provides functional changes to the films. Our results shows that the optimal coating time is on the order of few hours, whereby the films are optically transparent with excellent extensibility and Young’s modulus, while further coating reduces the benefits of this surface coating. These materials are biocompatible, serving as substrates for cell adhesion and growth while maintaining good viability. Overall, these findings give insight to the effects of PDA assembly on surfaces, and illustrate how a simple, quick, and robust bioinspired coating process can prime substrates for biomedical applications such as tissue engineering, biosensing, and wound healing.
Environmental pollution and population distribution among districts and counties: Evidence from prefecture-level cities in China
Authors: Wang Yongpei , Yang Jieru , Chen Jinwei , Zhang Qian
Published: September 2021

China's unprecedented urbanization has come at the cost of environmental degradation, which increasingly appears to be holding back migration to bustling municipal districts. Escaping from Beijing, Shanghai and Guangzhou has become a hot topic in recent years. But in fact, small and medium-sized cities also show signs of population decentralization. The aim of this paper is to reveal the impact of environmental pollution on the decentralization of urban population in China. Based on the panel data of over 227 prefecture-level cities and municipalities directly under the central government, the sensitivity of municipal population to PM2.5 concentration was empirically studied. The results showed that PM2.5 concentrations generally had the effect of driving away the population of municipal districts, but this was most pronounced in first-tier and fourth-tier cities rather than second-tier and third-tier cities. The panel quantile estimates further confirm this finding that megacities and small and micro cities rather than small and medium-sized cities are more vulnerable to environmental pollution, which is a reminder that Chinese policymakers must not focus on the environmental problems of megacities alone, but must prevent environmental degradation from hollowing out the population of small cities and towns.
Identification and Belonging: A Case Study of White German Women Converts to Islam
Authors: Sirri Lana
Published: September 2021

This study explores the possibilities of identification and belonging in a socio-religious space that contains multiple communal boundaries. It is based on narrated accounts of White Christian German women living in Berlin, Germany, who have converted to Islam. Their shared cultural background with other White German women, their new Islamic religion, and, for some, their intermarriage affiliation with Muslims, position these women in a complex relation to the multiple communities within this space. This intersectional positioning opens up possibilities for constructing, negotiating and articulating religious, cultural, and gender identification and belonging. This study aims to investigate how these women construct notions of gender, Islam and Muslimness, and how they position themselves in relation to communal boundaries of identification and belonging. It also explores the sense they make of their positionings, and how these are expressed in their daily lives. To this end, the research describes their encounters in the spheres of the community and the family. The research aims to contribute to an enhanced understanding of gutes Leben, the human flourishing, of White German women who have converted to Islam.
Striving for Synthesis in General Psychology: Lessons from India
Authors: Valsiner Jaan
Published: September 2021

The importance of the life-long contributions of Professor Sinha is in his search for new perspectives in psychology that would respect Indian cultural history. In that spirit, I will outline themes that are prominent in Indian cultural traditions from which universal science of human psychology could learn. All human beings relate to water and fertility, creating meaningful rituals of handling this valuable commodity. Likewise, it is deeply human to generate borders and social conditions for their crossings, and to participate collective rituals of symbolic processions. Psychology in the Occident has looked towards India as if it were an esoteric collection of local practices that would fit the empirical interests of cross-cultural psychology. I would claim that the psychological riches of India are of primary importance for general psychology.
Cultural Similarities and Variations in the Conceptions of Happiness and Unhappiness: A Comparison Between Italy and Honduras
Authors: Sotgiu Igor , Tirloni Licia , Zapata Julissa Thomas
Published: September 2021

The present study investigates the conceptions of happiness and unhappiness among university students from Italy and Honduras. A total of 193 Italians and 172 Hondurans took part in a questionnaire study. Respondents were asked to write down the things that made them happy ( happiness sources) and those that made them unhappy ( unhappiness sources). The content analysis of participants’ answers showed that there was a substantial agreement between Italians and Hondurans over the type of happiness and unhappiness sources they reported. However, the participants’ cultural background significantly influenced the perceived salience of a high number of these sources. Notably, we found several discrepancies between the participants’ cultural orientation and the semantic content of the happiness and unhappiness sources they assigned greater importance to. We also found gender differences in the perceived salience of happiness and unhappiness sources; however, these differences only referred to a small number of sources. The results were interpreted considering theory and research on individualism–collectivism.
‘Searching for Roots’: Exploring the Idea of Home in Tibetan Refugee Youth Living in Delhi, India
Authors: Ramanathan Pallavi , Singh Purnima
Published: September 2021

Home is a key aspect of place attachment signified by rootedness and ease; it is operationalised as a sense of being rooted to and feeling at ease in a particular place. Two studies were done to gain a nuanced idea of the concept of home as understood by Tibetan refugee youth living in Delhi. In study 1, based on in-depth interviews on 20 students of ages 18–25 years, a thematic analysis resulted in the global theme of ‘community as home’ indicating the central position of the community while talking about home. On the basis of this study, four variables were identified as key to the concept of home: in-group identification, group efficacy, social well-being and rootedness (home). Study 2 was designed to understand the relationship between these identified variables. Around 103 refugee youth (controlled for gender) aged 18–25 years completed the questionnaire. It was found that most of the variables were positively correlated to one another, except for group efficacy and social well-being. Further, the mediation analysis indicated that in the context of the community, higher levels of social well-being explained increased in-group identification, particularly when mediated by the presence of group efficacy. Overall, it was found that community seems to be integral to the concept of home for Tibetan refugee youth living in Delhi. Both studies expand upon existing literature on the concept of home and have further implications for the notion of home and the social well-being of Tibetan refugees.
“It’s a Bit of a Double-Edged Sword”: Motivation and Personal Impact of Bereaved Mothers’ Advocacy for Drug Policy Reform
Authors: Morris Heather , Hyshka Elaine , Schulz Petra , Jenkins Emily , Haines-Saah Rebecca J.
Published: September 2021

North America’s overdose crisis is an urgent public health issue that has resulted in thousands of deaths. As the crisis began to take hold across Canada in 2016, bereaved parents, mainly mothers, emerged as vocal advocates for drug policy reform and harm reduction, using their stories to challenge the stigma of drug-related death. In 2017, we launched a qualitative research partnership with leading family organizations in Canada, conducting interviews with 43 mothers whose children had died from substance use, to understand their experiences of drug policy advocacy. Our findings showed that participants’ motivations for engaging in advocacy were rooted in their experiences of grief, and that advocacy led to feelings of empowerment and connection to others. Our research suggests that advocacy can be cathartic and associated with healing from grief, but that “going public” in sharing a family story of substance use death can also have a considerable personal cost.
Barriers to and Facilitators of Neonatal Palliative Care Among Neonatal Professionals in China
Authors: Gu Lin , Li Zhen-Zhen , Peng Niang-Huei , Zhou Jian-Fu , Wei Bi-Rong , Chang Yue-Cune
Published: September 2021

Objectives:

This study investigated institutional and personal barriers to and facilitators of neonatal palliative care facing neonatal professionals in China.

Methods:

A cross-sectional questionnaire surveyed 231 neonatal clinicians employed in 5 neonatal intensive care units from 2 children’s hospitals and 3 medical centers in China.

Measurements:

The translated modified version of the Neonatal Palliative Care Attitude Scale was used to survey neonatal clinicians’ attitudes and beliefs regarding neonatal palliative care.

Results:

Findings highlight 4 facilitators and 5 barriers among participating clinicians. Participants gave contradictory responses regarding the relative importance of curative treatment versus palliative care in the NICU. Negatively traumatic feelings, cultural issues and moral distress may impact this contradictory response and discourage clinicians from providing neonatal palliative care. Additionally, neonatologists and nurses held differing attitudes on several topics (p < 0.05).

Conclusion:

Further research should address strategies to improve knowledge and attitudes and relieve moral distress in NICU clinicians. Neonatal clinicians providing neonatal palliative care should receive regular palliative care training addressing culture-specific issues and communication skills.

Practice Implications:

Study findings will be beneficial to inform clinical education and practice. Regular interdisciplinary team training is needed to enhance support for palliative care and decrease clinicians’ moral distress during end-of-life care.
Pilot Cohorts for Development of Concurrent Mobile Treatment for Alcohol and Tobacco Use Disorders
Authors: Medenblik Alyssa M , Calhoun Patrick S , Maisto Stephen A , Kivlahan Daniel R , Moore Scott D , Beckham Jean C , Wilson Sarah M , Blalock Dan V , Dedert Eric A
Published: September 2021

Alcohol and tobacco are the 2 most frequently used drugs in the United States and represent the highest co-occurrence of polysubstance use. The objective of this study was to refine an intervention combining mobile contingency management with cognitive-behavioral telephone counseling for concurrent treatment of alcohol and tobacco use disorders. Two cohorts (n = 13 total, n = 5 women) of participants were enrolled, with 10/13 completing treatment and 7/13 completing the 6-month follow-up. At enrollment, participants were drinking a mean of 28.9 drinks per week (SD = 14.1), with a mean of 14.7 heavy drinking days in the past month (SD = 9.9), and a mean of 18.1 cigarettes per day (SD = 11.7). Treatment included a mobile application that participants used to record carbon monoxide and breath alcohol content readings to bioverify abstinence. Participants received up to 4 sessions of phone cognitive-behavioral therapy and monetary reinforcement contingent on abstinence. In cohort 1, 4/6 participants reported abstinent or low-risk drinking post-monitoring. Six weeks post quit-date, 2/6 participants were CO-bioverified abstinent from tobacco use, with 2/6 in dual remission. These results were maintained at 6-months. In cohort 2, 6/7 reported abstinent or low-risk drinking post-monitoring, 5 weeks post quit-date. At the post-monitoring visit, 5/7 were CO-bioverified abstinent from smoking, with 5/7 in dual remission. At 6-months, 3/7 reporting abstinent or low-risk drinking, 1/7 had bioverified abstinence from smoking, with 1/7 in dual remission. Observations suggest that it is possible to develop a concurrent mobile treatment for alcohol and tobacco use disorders.
Reflecting on the use of Google Docs for online interviews: Innovation in qualitative data collection
Authors: Opara Victoria , Spangsdorf Sabrina , Ryan Michelle K
Published: September 2021

Google Docs is a widely used online word processing software. Despite its broad popularity in business and education, Google Docs is under-utilised as a tool to facilitate qualitative interviews within research. In this article, we reflect on our experiences as two PhDs using Google Docs to conduct synchronous, online, written interviews. We present two case studies, which, to our knowledge, are the first to utilise Google Docs to conduct web-based written interviews. In doing so, we (a) outline the development and implementation of the methodology, (b) highlight the key themes we identified when considering the benefits and challenges of conducting interviews using this technology and (c) discuss possible future uses of the methodology. We argue that synchronous web-based written interviews via Google Docs offer unprecedented opportunities for qualitative research.
Psychological Interventions for the Treatment of Chronic Pain in Adults
Authors: Driscoll Mary A. , Edwards Robert R. , Becker William C. , Kaptchuk Ted J. , Kerns Robert D.
Published: September 2021

The high prevalence and societal burden of chronic pain, its undertreatment, and disparities in its management have contributed to the acknowledgment of chronic pain as a serious public-health concern. The concurrent opioid epidemic, and increasing concern about overreliance on opioid therapy despite evidence of limited benefit and serious harms, has heightened attention to this problem. The biopsychosocial model has emerged as the primary conceptual framework for understanding the complex experience of chronic pain and for informing models of care. The prominence of psychological processes as risk and resilience factors in this model has prompted extensive study of psychological treatments designed to alter processes that underlie or significantly contribute to pain, distress, or disability among adults with chronic pain. Cognitive-behavioral therapy is acknowledged to have strong evidence of effectiveness; other psychological approaches, including acceptance and commitment therapy, mindfulness, biofeedback, hypnosis, and emotional-awareness and expression therapy, have also garnered varying degrees of evidence across multiple pain conditions. Mechanistic studies have identified multiple pathways by which these treatments may reduce the intensity and impact of pain. Despite the growing evidence for and appreciation of these approaches, several barriers limit their uptake at the level of organizations, providers, and patients. Innovative methods for delivering psychological interventions and other research, practice, and policy initiatives hold promise for overcoming these barriers. Additional scientific knowledge and practice gaps remain to be addressed to optimize the reach and effectiveness of these interventions, including tailoring to address individual differences, concurrently addressing co-occurring disorders, and incorporating other optimization strategies.
Application of Immune Checkpoint Inhibitors in the Treatment of Cholangiocarcinoma
Authors: Zeng Fan-li , Chen Jing-fang
Published: September 2021

Cholangiocarcinoma is a general term for intrahepatic and extrahepatic malignant tumors deriving in the biliary system. According to the location, it is divided into intrahepatic cholangiocarcinoma, hilar cholangiocarcinoma, and distal cholangiocarcinoma. Progressive cholangiocarcinoma yields poor outcomes with radiotherapy; therefore, there is an urgent need for new therapeutic breakthroughs. Immune checkpoint inhibitor (ICI) therapy brings the treatment for cancer into a new field, with the use of drugs targeting PD-1/PD-L1 and CTLA-4 considerably extending the survival of patients with melanoma, lung cancer, and other solid tumors. The FDA has approved the application of pembrolizumab for solid tumors with high microsatellite instability and defective mismatch repair, including cholangiocarcinoma. Moreover, the combination of ICIs with chemotherapy and radiation therapy showed good promise. The aim of the present study was to review the application of ICIs in the treatment of cholangiocarcinoma and to summarize the reported individualized immunotherapy-based protocols and ongoing clinical trials for clinical reference.
Undergraduate Medical Education During the Pandemic: How do Academic Staff Members in Greece and Cyprus Feel About it?
Authors: Eleftheriou Anna , Rokou Aikaterini , Doukaki Polyxeni , Kapetanios Ioannis , Diamantopoulou Panagiota , Papaioannou Theodore G. , Lytras Theodore , Papanas Nikolaos , Constantinidis Theodoros C , Nena Evangelia
Published: September 2021

This study used a questionnaire to examine how academic staff members in Greece and Cyprus feel about the changes in undergraduate medical education during the COVID-19 pandemic. In general, e-learning was not considered an adequate way of teaching and was less enjoyable. Participants aged 31-40 years experienced more ( P = .001), while staff in higher academic ranks less difficulty ( P < .001) in adjustment. There was a small increase in workload, which was higher among respondents researching into COVID-19 ( P = .001). During the pandemic, daily screen use >6 h was increased from 28.8% to 57.5%. The majority (74.2%) stated that scientific and educational training opportunities were not affected by the pandemic. In conclusion, the pandemic has induced important changes in undergraduate medical education. This new condition was considered adequate but not pleasant, with younger faculty members being more burdened.
Atherosclerotic lesion-specific copper delivery suppresses atherosclerosis in high-cholesterol-fed rabbits
Authors: Wang Na , Xu Xinwen , Li Hualin , Feng Qipu , Wang Hongge , Kang Y James
Published: September 2021

Dietary cholesterol supplements cause hypercholesterolemia and atherosclerosis along with a reduction of copper concentrations in the atherosclerotic wall in animal models. This study was to determine if target-specific copper delivery to the copper-deficient atherosclerotic wall can block the pathogenesis of atherosclerosis. Male New Zealand white rabbits, 10-weeks-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as control. Twelve weeks after the feeding, the animals were injected with copper-albumin microbubbles and subjected to ultrasound sonication specifically directed at the atherosclerotic lesions (Cu-MB-US) for target-specific copper delivery, twice a week for four weeks. This regiment was repeated 3 times with a gap of two weeks in between. Two weeks after the last treatment, the animals were harvested for analyses of serum and aortic pathological changes. Compared to controls, rabbits fed cholesterol-rich diet developed atherosclerotic lesion with a reduction in copper concentrations in the lesion tissue. Cu-MB-US treatment significantly increased copper concentrations in the lesion, and reduced the size of the lesion. Furthermore, copper repletion reduced the number of apoptotic cells as well as the content of cholesterol and phospholipids in the atherosclerotic lesion without a disturbance of the stability of the lesion. The results thus demonstrate that target-specific copper supplementation suppresses the progression of atherosclerosis at least in part through preventing endothelial cell death, thus reducing lipid infiltration in the atherosclerotic lesion.
Book Review: Rethinking and Reshaping Public Space: The Fascinating Story of a Moment and Movement in Urban Design in New York City
Authors: Nelischer Claire
Published: September 2021

The Invention of Public Space: Designing for Inclusion in Lindsay’s New York documents a transformative period of experimentation in public space design in New York City from 1966 through 1973, under the mayoralty of John Lindsay. Combining rich archival research with captivating storytelling, the book sheds light on this time in which emerging ideas about psychology, participation, and politics were integrated into the design of public environments. It makes a compelling argument for the importance of this time and place in spurring a broad rethinking of the very concept of public space as a site of democracy, participation, and self-actualization.
Politicians’ Ideology Matters More Than Their Race in Determining the Association Between White Identity and Evaluation of the Politicians
Authors: Bai Hui
Published: September 2021

White Americans’ racial identity can predict their sociopolitical attitudes and behaviors, demonstrating an emergent trend of White identity politics. However, when it comes to predicting support for political candidates, it remains an unclarified question whether the effects of White identity politics are determined more by candidates’ ideology or race. This article disentangles and compares the role of candidates’ ideology and race. Four studies using White American samples consistently support the ideology hypothesis, which suggests that White identity predicts support for conservative politicians and opposition to liberal politicians because of their ideology. The evidence is limited for the racial hypothesis, which suggests that White identity predicts support for White politicians but opposition to Black politicians because of their race. Thus, this article complements theories of White identity politics and clarifies implications for who might benefit from its growing influence.
Emergence of cutaneous Rosai–Dorfman disease during immunosuppressive treatment of follicular B-cell lymphoma: A case report
Authors: Kipfer Sharon L , Samycia Michael , Shiau Carolyn J
Published: September 2021

Background:

Sinus histiocytosis with massive lymphadenopathy, also known as Rosai–Dorfman disease, is a rare proliferation of non-Langerhans histiocytes. Cutaneous Rosai–Dorfman disease is a rare subtype of Rosai–Dorfman disease limited to the skin with variable clinical presentation.

Case summary:

A 59-year-old female with a history of osteoarthritis, hypothyroidism, and follicular B-cell lymphoma presented with pruritic, erythematous, dome-shaped papules that developed while on chemotherapy treatment. During cutaneous disease progression, the patient was further diagnosed with myelodysplastic syndrome. Histology review revealed patchy staining for S100 in the CD68+ histiocytes within the dermis with no enlarged histiocytes or emperipolesis. Given the absence of other findings, this was interpreted as cutaneous Rosai–Dorfman disease.

Conclusion:

There is still little known about the aetiology and pathogenesis of cutaneous Rosai–Dorfman disease. Non-specific immunohistochemistry in the midst of lymphoma, immunosuppressive treatments, and myelodysplastic syndrome produced a blurred diagnostic picture and delayed appropriate treatment, highlighting the diagnostic challenges of cutaneous Rosai–Dorfman disease.
European colonization and the emergence of novel fire regimes in southeast Australia
Authors: Adeleye Matthew Adesanya , Connor Simon Edward , Haberle Simon Graeme , Herbert Annika , Brown Josephine
Published: September 2021

The rapid increase in severe wildfires in many parts of the world, especially in temperate systems, requires urgent attention to reduce fires’ catastrophic impacts on human lives, livelihoods, health and economy. Of particular concern is southeast Australia, which harbours one of the most flammable vegetation types on Earth. While previous studies suggest climate and European activities drove changes in southeast Australian fire regimes in the last 200 years, no study has quantitatively tested the relative roles of these drivers. Here, we use a Generalized Linear Modelling to identify the major driver(s) of fire regime change in the southeast Australian mainland during and prior to European colonization. We use multiple charcoal and pollen records across the region and quantitatively compare fire history to records of climate and vegetation change. Results show low levels of biomass burned before colonization, when landscapes where under Indigenous management, even under variable climates. Biomass burned increased markedly due to vegetation/land-use change after colonization and a major decline in regional precipitation about 100 years later. We conclude that Indigenous-maintained open vegetation minimized the amount of biomass burned prior to colonization, while European-suppression of Indigenous land management has amplified biomass accumulation and fuel connectivity in southeast Australian forests since colonization. While climate change remains a major challenge for fire mitigation, implementation of a management approach similar to the pre-colonial period is suggested to ameliorate the risk of future catastrophic fires in the region.
Mindfulness for Singers: A Mixed Methods Replication Study
Authors: Czajkowski Anne-Marie Louise , Greasley Alinka Elizabeth , Allis Michael
Published: September 2021

Objectives:

Mindfulness has been explored in the clinical and educational fields but has rarely been studied in the music domain. This study investigated the effects of teaching eight-week Mindfulness for Singers courses on vocalists’ music education and performance.

Methods:

A mixed methods approach was utilized, which included controlled and randomized controlled trials using standardized and novel mindfulness measures pre- and post-intervention, interviews post-intervention and three months later, concurrent diaries, and a blinded teacher study. Participants included singing students (total n=52) and their teachers ( n=11) from a university and a music college over a period of two years.

Results:

Levels of mindfulness increased over the intervention for experimental participants in comparison to controls. Considering their total student cohort, teachers identified 61% of eligible mindfulness singing participants as having completed the mindfulness intervention. Experimental participants reported that learning mindfulness had positive effects in lessons, solo and group instrumental practices, and when performing on stage. They described more focus and attention, positive effects of increased body awareness on singing technique, enhanced socio-collaborative relationships, reductions in performance anxiety, and beneficial effects whilst performing, such as more expressivity and enjoyment.

Conclusions:

Learning mindfulness had positive holistic effects on vocal students and was well received by their mindfulness-naïve singing teachers. Findings suggest that it would be highly beneficial for mindfulness to be made available in music conservatoires and university music departments alongside singing lessons for singers to enhance their present experience as vocal students and their futures as performers and teachers.
Severe Social Anxiety Among Adolescents During COVID-19 Lockdown
Authors: Itani Mohamad H. , Eltannir Ekram , Tinawi Hayat , Daher Dima , Eltannir Akram , Moukarzel Adib A.
Published: September 2021

To study the prevalence of severe social anxiety (SSA) among a group of adolescents during the coronavirus disease of 2019 (COVID-19) pandemic. A total of 178 adolescents attending the private clinics of the authors were screened online for the presence of SSA, by using the self-reporting format of the Liebowitz Social Anxiety Scale for children and adolescents (LSAS-CA). SSA defined as LSAS-CA scores of 80 or more was checked for statistical association with the adolescents’ sociodemographic data and knowledge about the COVID-19 infection. The 18% of our participants had SSA, no correlation was found between having SSA and ä acknowledging or fearing the COVID-19 morbidity. Factors associated with SSA included texting, using social media, and playing video games during the lockdown. Mitigating factors include high family socioeconomic status, history of socialization with friends, and the use of WhatsApp as a source of information about COVID-19 infection.
“Hey, by the Way, I’m Transgender”: Transgender Disclosures as Coming Out Stories in Social Contexts among Trans Men
Authors: Kade Tristen
Published: September 2021

Connecting theories of identity formation and coming out with impression management, this research highlights that transgender disclosures are not static. Rather, disclosures are continuously mediated by various contextual concerns, ranging from accurate gender recognition, discrimination and stigmatization, the cultivation of emotional and physical intimacy, alerting people of the bodily changes, and understandings of how bodies will be perceived. Through 20 interviews with trans men, I found that they manage their trans identity through two tactics: symbolic disclosure and disclosure avoidance. Disclosure patterns reveal a twin force shaping disclosures: Trans men want gender recognition and/or to strengthen relationships while simultaneously avoiding potential violence, discrimination, and stigmatization. This research contributes to sociological scholarship on identities and disclosure more broadly by elucidating some ways trans men strategically negotiate disclosures based on a variety of concerns.
Inter-device measurement variability of vital data parameters for keratorefractive and cataract refractive surgery
Authors: Kanclerz Piotr , Przewłócka Katarzyna , Wang Xiaogang
Published: September 2021

Introduction:

The measurements of corneal white-to-white (WTW) diameter and pupil size are critical for decision making in refractive surgery. Currently, automatic measurement of keratometry, corneal WTW, and pupil size are implemented in several ocular devices. The purpose of this study was to examine the agreement between two commonly used devices, an autorefractor and an optical biometer, for these parameters.

Methods:

Measurements were performed with both a Lenstar LS-900 and Nidek ARK-1 by an experienced examiner in random order. The devices were placed in close proximity within the same dimly lit room.

Results:

The measurements of 65 right eyes were analyzed. The results of the flat, steep, and mean keratometric reading were not significantly different ( p = 0.96, p = 0.90, p = 0.93, respectively). Corneal WTW distances showed only moderate agreement between devices and were found to be significantly different ( r = 0.8071; p < 0.01). Pupil diameters showed poor agreement between devices and were significantly different ( r = 0.4890; p < 0.01). Agreement between implantable contact lens sizing, based on the measurements obtained by the two devices, was achieved for 19 of the 51 eyes (37.3%).

Conclusion:

We found a significant difference in WTW and pupil size measurements between ARK-1 and Lenstar. Results for both of the devices cannot be considered interchangeable for these data parameters.
During and beyond the frequent lockdowns: Addressing the pandemic (COVID-19)–related family violence through informal social control
Authors: Abdullah Alhassan , Cudjoe Ebenezer , Ryu Wonjung , Emery Clifton R
Published: September 2021

Growing literature on COVID-19 shows an increase in family violence and child maltreatment cases as a result of the public health preventive measures including lockdowns and movement restrictions. These restrictions negatively affect victims’ ability to seek social services or leave the violent relationship. There are some indications of hope, however, as countries have begun easing restrictions which may enable victims to seek social services. Yet, the fluidity of COVID-19, emergence of complex variants of COVID-19 virus, continues restrictions on face-to-face engagements and evidence of re-entry into lockdown suggest that social services would not be fully available for victims of family violence. We offer a practical community intervention approach through informal social control for victims of family violence during and even after the COVID-19 pandemic.