bluuebunny/crossref_metadata_2025 huggingface dataset:
Norwid and Edmund Chojecki – the Traveller
Authors: Gadamska-Serafin Renata
Published: June 2021

The writer Edmund Chojecki (Charles Edmond) was one of Norwid’s most significant acquaintances, already in the Warsaw period, and later in Paris. Their friendship started in Warsaw in the 1840s and lasted a lifetime (or at least until the 1870s), although its preserved epistolary traces are scarce. This article focuses on Chojecki’s reports from his travels and their inspiring influence on Norwid: Edmund’s trip with Count Branicki to the Crimea (Wspomnienia z podróży po Krymie, Warszawa 1845), journey to the North Seas with Prince Napoleon (Voyage dans les mers du Nord, Paris 1857), Chojecki’s sojourn in Egypt at the turn of 1851, and finally his involvement in preparing the Egyptian exhibition (as the commissioner general) at the 1867 World Exhibition in Paris (L’Égypte à l’Exposition universelle de 1867, Paris 1867). The most important outcome of this is Norwid’s drama Kleopatra i Cezar and his collection of Egyptian drawings in the album Orbis (I).
When Two Giants Come Close: Norwid and Dostoevsky
Authors: Zieliński Jan
Published: June 2021

A personal review of the book version of Ewangelina Skalińska’s doctoral thesis devoted to Norwid and Dostoevsky. It discusses the threefold composition of the dissertation and underlines the dashing comparative analysis of Norwid’s Assunta and Dostoevsky’s A Gentle Creature. The open character of the research project is stressed. The reviewer discusses in detail another parallel, between two London texts: Norwid’s The Larva and Dostoevsky’s Winter Notes on Summer Impressions. In conclusion there is a passage on the inspiring role of Skalińska’s book, which fills an important gap and draws a horizon for the future comparative research.
Comparing the incomarable
Authors: Masłowski Michał
Published: June 2021

The presented book is a contribution to the discussion about modernity and comparatistics in Norwid’s works, going on for about two decades. This publication was created by Polish specialists on Norwid, half of them affiliated with the Jagiellonian University. There is no predominant method in the volume under discussion — the range of subjects covers modernity and the transition between the epochs. What is left of the comparatistics proper is music and opera, visual arts, conceptual reflection, and translation issues.
A notebook with Norwid on the cover. Notes on the presence of Cyprian Norwid in volumes of poetry titled Kochanka Norwida and Nie dam ci siebie w żadnej postaci by Eugeniusz Tkaczyszyn-Dycki
Authors: Maryjka Wojciech
Published: June 2021

This article examines connections between the poetry of Eugeniusz Tkaczyszyn-Dycki and works by Cyprian Norwid, following Norwidian traces in the contemporary poet’s writings and attempting to reveal their meanings. Poems from collections titled Kochanka Norwida (2014) and Nie dam ci siebie w żadnej postaci (2016) are analysed and interpreted in terms of their frequent and obvious references to Norwid. It is argued that Norwid’s works have had a significant impact on the poetic identity of Tkaczyszyn-Dycki, while his references to Norwid do not stem merely from adopting a certain creative strategy but from Tkaczyszyn-Dycki’s exceptional experience of encountering the Romantic poet.
Releitura de pão de queijo: Versão vegetariana com farinha de oliveira
Authors: Santos Carolina Dias dos , Menezes Rafaella Câmara Rocha , Dal Bosco Simone Morelo
Published: June 2021

A oliveira (Olea europaea L.) é composta por folhas que podem ser consumidas, mas costumam ser descartadas pela colheita mecanizada. Uma alternativa para viabilizar o descarte das folhas de oliveiras, é elaborar a farinha de folha de oliveira (FFO) realizando o aproveitamento. Com isso, o objetivo desta pesquisa foi elaborar um pão de queijo vegetariano adicionado de farinha da folha de oliveira a fim de viabilizar uma nova alternativa de aproveitamento tecnológico desse resíduo. Foram desenvolvidas cinco formulações de pães de queijo, alterando-se a quantidade de farinha das folhas de oliveira adicionada (0,95 – 2,85%) e submetidas a avaliação das características sensoriais pelo método de Análise Descritiva Quantitativa. Os resultados demonstraram que, dentre os quinze atributos avaliados, os sabores herbáceo, amargo e de queijo juntamente com o aroma herbáceo apresentaram diferença significativa. Entre os atributos analisados, a FFO contribuiu para o maior sabor amargo dos pães de queijo, seguido de sabor e aroma herbáceo. Conclui-se que foi possível elaborar um pão de queijo vegetariano adicionado de farinha de folha de oliveira como uma alternativa de aproveitamento tecnológico desse resíduo.
miR-379-5p inhibits proliferation and invasion of the endometrial cancer cells by inhibiting expression of ROR1
Authors: Liang Minglin , Chen Hui , Min Jie
Published: June 2021

Endometrial cancer is a common gynecological malignancy, and the incidence of this disease has increased in recent years. Recently, some studies suggested that the expression of miR-379-5p suppressed the metastasis of breast cancer cells. However, whether the expression of miR-379-5p could affect the proliferation, migration and invasion of endometrial cancer is unclear. In this study, we established miR-379-5p overexpression and miR-379-5p inhibition in endometrial cancer cells. Next, EdU and colony formation assays were performed to measure proliferation of endometrial cancer cells. Wound healing and transwell assays were carried out to examine the migration and invasion of these cells. Then, luciferase reporter assay was performed to test the relationship between miR-379-5p and ROR1. Finally, we overexpressed ROR1 in miR-379-5p overexpressing endometrial cancer cells. Colony formation, wound healing and transwell assays were used to measure proliferation, migration and invasion of these cells. The results showed that overexpression of miR-379-5p repressed proliferation, migration and invasion of endometrial cancer cells. Higher levels of miR-379-5p repressed expression of N-cadherin, Vimentin and ZEB1. Overexpression of miR-379-5p also promoted expression of E-cadherin and ZO-1. In addition, miR-379-5p targeted and suppressed expression of ROR1. Overexpression of ROR1 abolished the inhibitory effect of miR-379-5p on proliferation, migration, invasion and EMT of endometrial cancer cells. All of these results indicated that miR-379-5p suppressed proliferation, migration and invasion of endometrial cancer cells by inhibiting the expression of ROR1 and the EMT process.
Experimental Investigation on Vibration Responses of Fiberglass Reinforced Plastic
Authors: Endriatno Nanang
Published: June 2021

The purpose of this study is to analyze the vibration displacement on fiberglass reinforced plastic beams with variations a number of fibers in the resin matrix. Composite beams was made of fiberglass and polyester resin matrix with a number of fiberglass: 0, 24, and 48. Composite beams was manufactured by hand lay-up method with the unidirectional fiber orientation. The composite beams used have the dimension of length: 500 mm, height: 20 mm, and width: 20 mm. During the experimental test, the beam was vibrated using an exciter motor which was placed at the end of the cantilever support then using a vibration meter, the vibration displacement data (mm) was measured by placing the vibration transducer postions : 50 mm, 250 mm, and 450 mm from the cantilever support. During the vibration test, the vibration displacement data on the vibration meter screen were recorded using a camera recorder and the data was taken 6 times at each of measurement points. The experimental and analysis results show that the value of vibration displacement (mm) decreases when the fiberglass is added to the composite beam, or in other words, the addition of fiberglass provides an increase in the ability of the beam to withstand vibrations. The maximum vibration displacement value on composites with 0 fiberglass: 0.641 mm, then the vibration displacement decreased in composites with 24 fiberglass: 0.506 mm and the lowest displacement value for the composites with 48 fiberglass: 0.395 mm. Whereas for 3 measurement points at positions 5 cm, 25 cm, and 45 cm along the beam for three kind of the composites, the maximum value of vibration displacement value was obtained at the end of beam composites or at 45 cm from cantilever support: 0.735 mm on composite beam with 0 fiberglass and minimum at position 5 cm near the cantilever support with the value of vibration displacement: 0.323 mm on composite beam with 48 fiberglass.
Constructivism Applied: An Example from the Teaching of Computing
Authors: Hinton Brian
Published: June 2021

The state of science education is similar to that of other disciplines: research shows a clear need for new instructional strategies based on a constructivist model of learning emphasizing conceptual growth, conceptual change and the conditions that support conceptual change. Practice, however, remains anchored in behaviorist theory and rote methods of learning. “Serious constructivist approaches usually set out to reorganize traditional teaching by including changes of aims, setup of content structures, media, and teaching/learning strategies” (Treagust et al, 1996, p7). Maher and Alston (1990) discuss constructivist reform efforts and the implications for classroom teaching focusing on three issues that arise repeatedly: how to learn to listen to students’ thinking; how to organize classroom activities to support “listening and questioning”; and how to implement forms of assessment that document students’ questions.

This paper describes some constructivist teaching methodology and practices, and highlights their effectiveness as an aid to teaching and understanding in the classroom.
Implementación de herramientas virtuales como estrategia para mejorar los procesos de enseñanza/aprendizaje (E/A) en la educación media
Authors: Ortegon Fernandez Yamileth , Delgado John Alejandro
Published: June 2021

El presente artículo muestra los resultados al realizar la implementación de una metodología b-Learning para generar un conocimiento constructivista en los estudiantes que cursaban la asignatura de Física del Colegio Técnico Comfacauca. El proyecto se realizó en tres fases: diagnóstico, desarrollo del EVA e implementación y puesta en marcha del EVA, cada una de estas fases estuvo acompaña de actividades que soportaron la temática elegida y se basaron en la participación activa del estudiante. Los resultados obtenidos muestran que el 53% del grupo experimental alcanza una nota igual o superior a 3.5, mientras que esto ocurre solo con el 39% del grupo control; por ende, se observa un mejor desempeño académico y un grado de satisfacción aceptable hacia el uso espacios virtuales por parte de los estudiantes, lo que permite evidenciar que a través de un modelo b-Learning se pueden crear canales asertivos de comunicación e interacción con el estudiante que influyen en su rendimiento académico y generan un proceso de aprendizaje independiente.
Od Pauzaniasza do Baedekera i serwisu Tripadvisor: prototuryzm tekstualny oraz zagrożenia dla kanałów dystrybucji turystycznej
Authors: Katsoni Vicky , Fyta Anna
Published: June 2021

Głównym celem autorek artykułu jest interdyscyplinarne spojrzenie na turystykę i jej diachroniczne wątki tekstualne w prototurystycznych pismach Pauzaniasza – greckiego autora opowieści o podróżach. Korzystając z periegetycznych tekstów podróżniczych, zaczerpniętych z jego obszernego dzieła Wędrówki po Helladzie (Periegesis tes Hellados; II w. n.e.), będącego punktem wyjścia do rozważań, autorki zamierzają pokazać, że strategie tekstualne Pauzaniasza wciąż stanowią podstawę współczesnej serii przewodników turystycznych, zapoczątkowanej przez K. Baedekera w XIX w. Celem opracowania jest również wykazanie, że po Baedekerze tradycyjne teksty podróżnicze Pauzaniasza nadal mają wpływ na epistemologię współczesnej turystyki: interakcje między tekstami podróżniczymi, zawierającymi informacje turystyczne, a kanałami dystrybucji prowadzą do pojawienia się generycznych hybryd, a starożytni greccy autorzy podróży utorowali drogę do tworzenia cyfrowych opowiadań, sieci i globalnych platform turystycznych.
Restorative treatment decisions regarding approximal and occlusal carious lesions among general dental practitioners in Palestine
Authors: Rabi Tarek , Arandi Naji Ziad
Published: June 2021

Aim: To investigate restorative decisions made by dentists and to examine what demographic characteristics are associated with the decisions for managing approximal and occlusal lesions. Methods: A questionnaire was randomly sent to 900 Palestinian dentists. It noted the demographic details of the dentists and the years of experience. The questionnaire evaluated the respondents for their treatment decisions regarding approximal and occlusal carious lesions. The data was analyzed using the IBM SPSS statistics for windows. The associations between gender and years of experience of the respondents and their restorative decisions were assessed. Results: The response rate was 58.2%. For occlusal carious lesions, 93.9% of the respondents would postpone operative treatment until the lesion was in dentine (grade 3 to 5). For approximal lesions, intervention was deemed appropriate by 92.6% of the respondents when there was radiographic evidence of a carious lesion reaching the DEJ or deeper. Around 53% preferred to prepare approximal lesions according to the traditional principles of cavity preparation. For both approximal and occlusal lesions, the participants opted for resin composites. Statistically, there was a significant association between the restorative decisions with the years since graduation and gender. Conclusion: The study showed variations between the treatment decisions of Palestinian dentists. The subjects chose conservative treatment plans but still adhered to traditional learned practices especially when cavity preparation for approximal lesions was concerned. The years since graduation and gender played a significant role in the choice of treatment opted for. Resin composites seemed to be a popular choice for treatment.
ANALISIS EFISIENSI TURBIN UAP UNIT 1 DI PT. PJB UBJOM PLTU PULANG PISAU KALIMANTAN TENGAH
Authors: Saputro Edi
Published: June 2021

This study aims to determine the performance of steam turbine PT. PJB UBJOM PLTU Pulang Pisau Kalimantan Tengah the results of data obtained during each performance test in commisioning 2016 and 2018. This research data is taken from the control room of PT. PJB UBJOM PLTU Pulang Pisau, variable data obtained in the form of load, main inlet steam temperature, main inlet steam pressure, HP heater feed outlet temperature, HP heater feed outlet pressure, main steam flow, and turbine by pass flow. The data is processed to get the turbine heat rate and the efficiency per time of each performance test and then averaging the data results over time, then comparing the turbine heat rate and the average efficiency of each performance test. The calculation of turbine heat rate using heat & mass balance method, turbine efficiency is obtained by comparing the energy of 1 kW with turbine heat rate and multiplying 100%. The result of the average heat turbine calculation per performance test highest ie September 2016 is 3,51and Juli 2018 is 3,27. The average value of turbine efficiency in September 2016 was 29,03% and Juli 2018 was 33,84. Turbine power plant performance of PT. PJB UBJOM PLTU Pulang Pisau increase from 2016 to 2018 by 4,81 %.Keywords:Turbin Heat Rate, Efisiensi Turbin
PENGARUH VARIASI SUHU DAN MEDIA PENDINGIN PADA PROSES PACK NITRIDING MATERIAL SUS 630 TERHADAP NILAI KEKERASAN DAN STRUKUR MIKRO
Authors: SILALAHI YOSEPH NETANYAHU , Tamjidilllah Mastiadi
Published: June 2021

This research investigates the application of material engineering techniques on Stainless steel SUS 630 so that it not only has good resilience and resistance to corrosive properties but also has hard properties on its surface. In an effort to improve the quality of violence on the surface, among others, by surface hardening technique, one of which is a heat treatment technique by adding nitrogen elements to the surface of a material called the nitriding pack process. The nitrogen source in the pack nitriding process comes from urea (CO(NH2)2) with a nitrogen content of 46%. Parameters for controlling this study using variables by applying temperature variations (4200C, 4700C, 5200C, 5700C, 6200C)  and cooling media (inside the furnace, room temperature, and with fan) with a holding time of 2 hours. To evaluate this study microstructure testing, diffusion layer testing and micro hardness testing were carried out. From the results of the test it was found that there was no significant transformation of the microstructure shape when comparing with raw material, the optimal value of diffusion layer was in the cooling furnace with a temperature of 6200C with an average of 4.57 μm and white layer 0.53 , the highest hardness was at 6200C with cooling in furnace media which has a value of 80.9 HRN.
PENGARUH TIPE KACA PENUTUP 1 SISI DAN 2 SISI DENGAN ABSORBER TEMBAGA PADA SOLAR DISTILLATION TERHADAP PRODUKTIVITAS KONDENSAT AIR LAUT
Authors: Wibowo Agung , Tamjidillah Mastiadi
Published: June 2021

Distilasi matahari merupakan suatu alat yang memanfaatkan energi radiasi matahari sebagai sumber panasnya. Penelitian ini membandingkan destilasi surya tipe penutup kaca 1 sisi dan 2 sisi dengan penyerap tembaga. Tujuan dari penelitian ini adalah untuk mengetahui perpindahan kalor yang terjadi, produktivitas air yang dihasilkan dan kualitas air yang dihasilkan. Penelitian dilakukan selama 4 hari. Hasil penelitian menunjukkan bahwa distilasi surya dengan penutup kaca 1 sisi lebih baik dibandingkan dengan penutup kaca 2 sisi. Ini terlihat dari produktivitas air yang dihasilkan. Distilasi surya dengan penutup kaca 1 sisi memiliki produktivitas air 468 ml, sedangkan destilasi surya dengan penutup kaca 2 sisi hanya 450 ml. Perpindahan panas konduksi tertinggi terjadi pada distilasi surya dengan penutup kaca 1 sisi sebesar 4064,6 Watt. Untuk konveksi perpindahan panas tertinggi terjadi pada destilasi surya dengan penutup kaca 1 sisi yaitu 0,16 Watt. Perpindahan panas radiasi tertinggi terjadi pada destilasi surya dengan penutup kaca 1 sisi sebesar 34,7 Watt. Hasil penelitian kualitas air yang dihasilkan oleh kedua distilasi surya tersebut adalah air tersebut dapat dikategorikan sebagai air bersih. Solar distillation is a device that utilizes solar radiation energy as a source of heat. This research compares solar distillation with 1 sided and 2 sided glass cover type with copper absorber. The purpose of this research is to determine the heat transfer that occurs, the productivity of the water produced and the quality of water produced. Research is doing for 4 days. The results of this research that solar distillation with 1 sided glass cover is better to 2 sided glass cover. This is seen from the productivity of the water produced. Solar distillation with 1 sided glass cover has a water productivity of 468 ml, while solar distillation with 2 sided glass cover is only 450 ml. The highest conduction heat transfer is in solar distillation with 1 sided glass cover is 4064.6 Watts. For the highest convection heat transfer is in solar distillation with 1 sided glass cover is 0.16 Watt. The highest radiation heat transfer is in solar distillation with 1 sided glass cover is 34.7 Watts. The results of research the quality of water produced by both solar distillation is that the water can be categorized as clean water.
RE-DESIGN SISTEM DISTRIBUSI AIR BERSIH DAN FIRE HYDRANT DI GEDUNG PLN UP3B KALSELTENG
Authors: Aji Anas Satria , Siswanto Rudi
Published: June 2021

Sistem penyediaan dan distribusi air bersih di gedung-gedung bertingkat sering mengalami kendala. Tidak terkecuali PT. PLN (Persero) Gedung UP3B Kalselteng yang tidak luput dari permasalahan tersebut. Untuk itu perlu dilakukan perancangan ulang sistem distribusi dan penyediaan air bersih serta hidran kebakaran pada gedung. Tujuan dari penelitian ini antara lain menganalisis kebutuhan dan distribusi air bersih dan hidran kebakaran di dalam gedung. Kebutuhan air bersih dihitung berdasarkan jumlah penduduk yang mengkonsumsi air bersih, jenis dan jumlah unit beban alat perpipaan. Perhitungan head loss pada pipa menggunakan persamaan Hazen - William, Darcy-Weisbach dan Colebrook-White. Clean water supply and distribution systems in high-risk buildings often experience problems. No exception is the PT. PLN (Persero) UP3B Kalselteng Building which did not escape this problem. For this reason, it is necessary to re-design the distribution system and provide clean water and fire hydrants to the building. The objectives of this study include analyzing the needs and distribution of clean water and fire hydrants in the building. Clean water needs were calculated based on the number of people that consuming the clean water, the type and number of plumbing tools load unit. Calculation of head  loss  in  pipes  used Hazen – William, Darcy-Weisbach  and  Colebrook-White equation.Clean water supply and distribution systems in high rise buildings often experience problems. No exception is the PT. PLN (Persero) UP3B Kalselteng Building which did not escape this problem. For this reason, it is necessary to re-design the distribution system and provide clean water and fire hydrants to the building. The objectives of this study include analyzing the needs and distribution of clean water and fire hydrants in the building.Clean water needs was calculated based on the number of people that consuming the clean water, the type and number of plumbing tools load unit. Calculation of head  loss  in  pipes  used Hazen – William, Darcy-Weisbach  and  Colebrook-White equation.
A plaidoyer for the unique tourism accounts (dilemmas, difficulties and questions)
Authors: Stipetić Vladimir
Published: June 2021

Tourism is recognised as an important economic, social and cultural factor in modern societies. However, statisticians still face an enormous challenge when it comes to measuring the economic importance of tourism for given national economy. In his paper author examines the position of tourism in European System of Accounts (acronym ESA), from 1995. He comes to the conclusion that is impossible to get the full answers on the importance of tourism for the given national economy within those frameworks. The main reason for such conclusion he has found in the fact that tourism is the multifacet activity, with difficult concept to define, let alone measure. He gets the proof for his conclusion by comparing the different methodologies for defining who is the tourist, finding in application at the moment six different criteria’s. The results obtained are, of course, differing considerably, what makes them strictly incompatibles. The comparison of such data's is for that reason difficult to make and when made comparative results are of limited use. Author advocates a need to make on international level a Unified Tourism Economic Account (UTEA), covering the main activities of tourism sector. He regards the existing work by OECD and WTO as a good basis for further work. Only when majority countries would make UTEA, based on accepted methodology, could be the cross-country comparison made on scientific basis.
Gender Differences in Social Networks Based on Prevailing Kinship Norms in the Mosuo of China
Authors: Mattison Siobhán M. , MacLaren Neil G. , Liu Ruizhe , Reynolds Adam Z. , Mattison Peter M. , Baca Gabrielle D. , Zhang Meng , Sum Chun-Yi , Shenk Mary K. , Blumenfield Tami , von Rueden Christopher , Wander Katherine
Published: June 2021

Although cooperative social networks are considered key to human evolution, emphasis has usually been placed on the functions of men’s cooperative networks. What do women's networks look like? Do they resemble or differ from men's and what does this suggest about evolutionarily inherited gender differences in reproductive and social strategies? In this paper, we test the ‘universal gender differences’ hypothesis positing gender-specific network structures against the ‘gender reversal’ hypothesis that posits women's networks looking more 'masculine' under matriliny. Specifically, we ask whether men's friendship networks are always larger than women's and we investigate measures of centrality by gender and descent system. To do so, we use tools from social network analysis and data on men’s and women’s friendship ties in matrilineal and patrilineal Mosuo communities. In tentative support of the gender reversal hypothesis, we find that women's friendship networks in matriliny are relatively large. Measures of centrality and generalized linear models otherwise reveal greater differences between communities than between men and women. The data and analyses we present are primarily descriptive given limitations of sample size and sampling strategy. Nonetheless, our results provide support for the flexible application of social relationships across genders and clearly challenge the predominant narrative of universal gender differences across space and time.
Carbon Lock-in and Contradictions – Teaching Mexico’s Energy Transition
Authors: Hernandez Ariel Macaspac , Pacheco Rojas Daniel Alejandro , Barrón Villaverde Diana
Published: June 2021

The energy sector plays an important role in Mexico’s development trajectory. Mexico makes an interesting case study, because it shows how difficult it is to reduce fossil energy dependence despite geographic and climatic conditions that favour renewable energy deployment and use. Resolving path dependencies and the related carbon lock-in are key to Mexico’s sustainable energy transition. This case study aims to identify and discuss how carbon lock-in affects Mexico’s sustainable energy transition. Mexico’s carbon lock-in involves oil and oil-run power plants that are costly to build but relatively inexpensive to operate. This case study identifies potential entry points for transitioning towards sustainable energy in Mexico – resources that can promote the use of clean energy despite carbon lock-in. For example, focusing on electrification – particularly of the carbon-intensive sectors – can help Mexico transit towards sustainable energy despite institutional constraints. Complementing this case study is a teaching guide with recommendations for using Mexico’s energy transition in courses on sustainability. It introduces a “learning activation framework” to identify emerging opportunities that can advance sustainable energy transitions in different cases of carbon lock-in. Finally, the framework also gives students a chance to help dismantle or cope with carbon lock-ins.
A Functional Study of the TatD DNases of Trueperella pyogenes and the Conformational Analysis of Luteolin as an Inhibitor
Authors: Zhang Zehui , Liang Yinfeng , Yu Lihui , Chen Menghan , Guo Yuru , Kang Zhiruo , Qu Chenghu , Tian Chunlian , Zhang Dexian , Liu Mingchun
Published: June 2021

Trueperella pyogenes (T. pyogenes) can cause a variety of infections in animals and lead to economic loss in animal husbandry. TatD DNases are considered to be potential virulence factors in Plasmodium falciparum and Streptococcus pneumoniae. However, the function of TatD DNases in T. pyogenes is still unclear. Therefore, the aim of this study was to illustrate the function of TatD DNases of T. pyogenes (TpTatDs) and investigate whether luteolin is able to inhibit DNase function. The findings of our study are anticipated to be crucial to treating infections caused by T. pyogenes. Bioinformatic analysis has been used for the prediction of crucial functional residues of TpTatDs. The function of TpTatDs was investigated in the presence of divalent cations by hydrolyzing DNA with recombinant TatD proteins. Luteolin is a candidate nuclease inhibitor evaluated in our study. The interactions between luteolin and TpTatDs were tested using molecular docking analysis and surface plasmon resonance (SPR) assays. The inhibitory effect of luteolin on TpTatDs was analyzed by agarose gel electrophoresis. Two genes in the genome of T. pyogenes are suspected to encode TatD DNases. According to the length of their nucleotide sequences, they were named tatD960 and tatD825. Both of the TpTatDs, which are magnesium-dependent, were able to hydrolyze linear DNA and plasmids. In this study, we found through molecular docking analysis and SPR assays that luteolin can stably bind with TpTatDs. The gel assay revealed that luteolin can inhibit the DNase activity of TpTatDs. Our results indicated that TatD DNases from T. pyogenes are Mg2+-dependent DNases and exhibit DNA endonuclease activity. Moreover, luteolin reduced their DNA hydrolysis ability by decreasing the binding between TpTatDs and DNA.
Tendon Transfers for the Treatment of Finger Flexion Weakness in a Patient With Inclusion Body Myositis
Authors: Thompson Austin R , Brant Jason E , Ensrud Erik R , Mirarchi Adam J
Published: June 2021

Case:

We describe a 71-year-old patient with inclusion body myositis (IBM), characterized by progressive atrophy and weakness in his left upper extremity. This patient underwent extensor carpi radialis longus to flexor pollicis longus and brachioradialis to flexor digitorum profundus tendon transfers in the left upper extremity to reduce IBM-related functional deficits. He had noticeable improvements in finger flexion after the transfers, which have been sustained for 2 years after the procedure.

Conclusion:

This case reinforces that this novel tendon transfer may be an effective treatment option to improve hand function and activities of daily living in patients with IBM.
Irreducible Chronic Volar Dislocation of the Distal Radioulnar Joint After Surgery for Distal Radius Fracture
Authors: Kamekura Satoru , Hosaka Yoko , Sasaki Gen , Miyamoto Hideaki , Kimura Michio , Hirota Jinso
Published: June 2021

Case:

We report a case of irreducible chronic volar dislocation of the distal radioulnar joint (DRUJ) after surgery for distal radius fracture. The patient underwent volar locking plate fixation for distal radius fracture. Despite the satisfactory alignment of the distal radius, irreducible volar dislocation of the DRUJ was discovered at 5 weeks after the initial surgery. DRUJ reconstruction at 9 weeks after injury using the Adams-Berger procedure resulted in a stable and functional DRUJ and wrist.

Conclusion:

To prevent postoperative DRUJ instability or dislocation, the DRUJ should be evaluated for stability immediately after fracture fixation.
Opening up Educational Practices through Faculty, Librarian, and Student Collaboration in OER Creation: Moving from Labor-intensive to Supervisory Involvement
Authors: McGeary Bryan , Guder Christopher , Ganeshan Ashwini
Published: June 2021

This article presents a case study for transitioning library-led open-educational resources (OER) initiatives away from labor-intensive activities to a model where library personnel focus on project management responsibilities. This shift from labour-intensive activities, such as workshops and training sessions, led to more collaborative partnerships with faculty and students to produce OER projects. In particular, we focus on labour implications for the various stakeholders involved and the sustainability of these initiatives. We describe several initiatives undertaken by the Ohio University Libraries to encourage open educational resource adoptions and projects, including a grant-funded initiative to provide support services for faculty creating OER. That funding, which was awarded to enhance undergraduate education, has been used to support the development of five OER projects that have directly involved students in the creation of those materials. We provide an overview of the various ways in which students have become involved in OER creation in partnership with faculty and librarians and discuss the impact these partnerships have had on student-faculty-librarian relationships and student engagement. Among these projects are an Hispanic linguistics open textbook created using only student-authored texts, student-generated test banks to accompany existing OER materials for a large-enrollment art history course, and several other projects in which hired student assistants are helping faculty to develop content for open textbooks. This article helps to address a gap in the literature by providing transparency regarding the personnel, costs, and workflow for Ohio University Libraries’ OER initiatives and addressing potential areas of concern surrounding student labour.
Experimental and Simulated Comparison of Finite Element Models of Bimetallic Sheets for Deep Drawing Process
Authors: Dengiz Cengiz Görkem , Yildizli Kemal
Published: June 2021

In this study, different techniques using for modeling of bimetallic sheets by finite elements method has been compared. Sheets modeled with 5 different assumptions were compared with each other and experimental datas, to determine the FE model that gives the most realistic result. FE models were created with the assumption that the adhesion was excellent or separable, and with the case that the solidified adhesive in the intermediate layer was modeled and not modeled. As a result, the closest values to the experimental results were obtained with the model created with the assumption that there is a solidified adhesive layer in the middle layer and there is an adhesion interface between this layer and metallic layers. On the other hand, when the adhesive is not modeled in the intermediate layer, it has been observed that the CPU time is reduced by 2 times while the results are seen small changes.
Above and Beyond Safety: Psychosocial and Biobehavioral Impact of Autism-Assistance Dogs on Autistic Children and Their Families
Authors: Tseng Angela
Published: June 2021

Autism-Assistance Dogs (AADs) are highly-skilled service animals trained primarily to ensure the safety of an autistic child by preventing elopement and mitigating “meltdowns”. Whereas families with AADs attest anecdotally to the psychosocial and behavioral benefits of their dogs above and beyond safety, quantitative, empirical support for these reports is lacking. The present study investigated the effects of well-trained AADs using validated clinical, behavioral, and physiological measures. We recruited families (N=13) from the top of an accredited training dog organization’s wait-list for AADs and collected pre/post-AAD data using a within subject, repeated measures design. Our findings demonstrate that, in addition to enhancing child outcomes, the integration of well-trained AADs can impact families positively across multiple domains of health and function.
Exploration of Anti-Staphylococcus Aureus Activity and Molecular Mechanism of Wuweixiaoduyin using Network Pharmacology Anti-Staphylococcus Aureus Activity of Wuweixiaoduyin using Network Pharmacology
Authors: Huang Kai , Lin Bigyuan , Ren Haiyong , Mao Qifen , Guo Qiaofeng , Liu Yiyang , You Qi
Published: June 2021

Background:S. aureus (Staphylococcus aureus) infection imposes a serious burden to global healthcare systems. WWXDY (Wuweixiaoduyin) is a traditional Chinese medicine, and it is usually used to treat infections in China. This study aimed to explore the active compounds, therapeutic targets, key pathways, and potential mechanisms of WWXDY in the treatment of S. aureus infection. Materials & Methods:Data related to active compounds and therapeutic targets of WWXDY for treating S. aureus were collected from DisGeNET, GeneCards, and DrugBank databases. To explore the roles of the active targets in gene function and signaling pathways, KEGG (Kyoto Gene and Genomics Encyclopedia) pathway enrichment and GO (Gene Ontology) analyses of the 122 target genes in the PPI (protein-protein interaction) network were performed. We further performed NP (network pharmacology) by using a network analyzer to screen 30 key targets. Results:A total 92 active compounds of WWXDY were screened. The 122 overlapped genes were found from 785 therapeutic targets and 684 S. aureus-related genes. Besides, 92 active compounds of WWXDY, such as mandenol, ethyllinolenate, eriodyctiol, secologanic dibutylacetal_qt, etc., were identified. The PPI network of the effective ingredients of WWXDY in treating S. aureus infection identified the top 30 genes, including IL-6 (interleukin-6), TNF-α (tumor necrosis factor-α), VEGFA (vascular endothelial growth factor A), AKT1, CXCL8, MAPK3 (mitogen-activated protein kinase 3), TLR (toll-like receptor 4), IL-1β, EGFR (epidermal growth factor receptor), and MMP9 (matrix metalloproteinase-9). Conclusion:The GO functional and KEGG pathway enrichment analyses indicated that 122 overlapped genes were mainly enriched in COVID-19, AGE-RAGE signaling pathway, C-type lectin receptor signaling pathway, Pertussis, and Chagas disease. Our findings indicated the active compounds and therapeutic targets of WWXDY in treating S. aureus infection, as well as its potential mechanisms.
Species Distribution Modeling And Assessment of Environmental Drivers Responsible To Distribution And Preferred Niche of Critically Endangered Endemic Ornamental Freshwater Fish Species of The Genus Sahyadria
Authors: Pathak Ajey Kumar , Verma Pushpendra , Dayal Rajesh , Sarkar Uttam Kumar
Published: June 2021

India has different bio-climatic zones that support diverse aquatic habitats rich in biodiversity. For effective conservation of endangered species in its habitat, it is essential to know the distribution of the fish species in the environmental range and for this species distribution models are the efficient and innovative tools. The present study used MaxEnt model to develop the probability distribution model highlighting the distribution of the fish species by analyzing the known occurrence records of Denison barb under genus Sahyadria (Sahyadria denisonii Day 1865 and Sahyadria chalakkudiensis (Menon, Rema Devi & Thobias 1999)) in relation to environmental variables typically incorporating seasonal and temporal variability. AUC of the models for Sahyadria species depicted good fitness. Both the species were found sensitive to 'Solar radiation', 'Temperature seasonality' and 'Temperature annual range' and these variables were assessed as the significant predictors. The sensitivity of distribution of both species to these environmental variables was found correlated with their breading and spawning seasons. 'Precipitation' was determined as a significant climatic envelop influencing distribution of the species associated with the river flow. The models showed that distribution of S. denisonii in the higher precipitation areas compared to S. chalakkudiensi. The probability distribution model with respect to distribution of both the species indicates a lineage barrier at Palghat Gap supporting the studies of earlier workers. At the latitudinal scale, prediction of the suitable ecological habitat provides the detailed insight into the distribution of all the genetic lineages of the genus Sahyadria. Evidently, the findings of this study can assist in determining ecological niches for other threatened and endangered species of other areas and may aid in field surveys as well as developing conservation plans.
Epidemiological effects in Amyotrophic Lateral Sclerosis from the application of a DTCP
Authors: Esposito Massimo , Sartori Marcello , Terlizzi Emilio , Antenucci Roberto , Braghieri Elena , Raggi Rossella , Benvenuti Michela , Pinotti Maria Teresa
Published: June 2021

This article introduces the report on the difference occurred in management of ALS patients by an italian Public Health Care Service through 15 years with-and without DTCP (Diagnostic and Therapeutic Care Pathway) during three timeframes. The article illustrates Demography, Provenance and Territorial context of the patients in charge. The formalization of the staging-based ALS DTCP appears to have increased and improved the possibility of clinical taking in charge of patients.
Atmospheric Changes and Ozone Increase in Mexico City during 2020 Lockdown Period
Authors: Jeyakumar Sakthi Selvalakshmi , Ponniah Jonathan Muthuswamy , Gnanachandrasamy Gopalakrishnan , Morales-Garcia Sandra Soledad , Rodríguez-Espinosa Pedro Francisco , Muthusankar Gowrappan , Escobedo-Urias Diana Cecilia
Published: June 2021

Atmospheric pollutant (NO2, SO2, CO, O3 and PM2.5) variations during the COVID-19 pandemic (during 2020) have been studied from Mexico City in Central America. Meteorological factors (i.e) rainfall, temperature along with relative humidity played an important role in increasing the photochemical reaction for the formation of O3 and PM2.5. Concentration pattern of O3 and PM2.5 were higher in all the stations in spite of the reduced primary pollutants. However, higher level of O3 and PM2.5 during the lockdown period in 2020 is mainly due to the air-mass exchange which happened through the broader channel in the north (Tenango del Aire Pass) and in the southeast (Cuautla-Cuernavaca valley). The higher values of particulate matter are compensated by domestic heating (“Quédate en Casa”/ Stay at Home), whereas the increase of O3 is supported by the higher solar radiation and household activities (both indoor/ outdoor). Monitoring stations (BJ, GAM, UAM, SFE) in Mexico City indicate that the level of pollutants (except GAM) were within the WHO guidelines. Comparison of pollutants with other countries indicate a spike in NO2, O3 and PM2.5 levels. Overall results indicate that the anthropogenic activities which is influenced by the meteorological parameters has affected the air quality in Mexico City and it persisted during the lockdown period.
Perfect Selective Metamaterial Absorber With Thin-Film of GaAs Layer In The Visible Region For Solar Cell Applications
Authors: Kumar Raj , Singh Bipin K , Tiwari Rajesh K , Pandey Praveen C
Published: June 2021

In this paper, we have presented a new design of a metamaterial perfect absorber (MPA) consisting of three layers of metal-dielectric-metal in which the top layer is considered of special kind square patches at different places in a unit cell. This MPA exhibits wideband, wide-angle, and polarization-independent absorption performance in the visible region. This structure originates the plasmonic resonance which is responsible for the perfect absorption in the optical region. Under a specific condition, this simulated absorber structure exhibits an extremely high broadband absorption between 591.54 nm to 704.40 nm wavelength range with near-unity absorption, and a single peak observed at 385.33 nm with absorption 94.16%. We extracted the impedance of the absorber and matched it with free space, and also demonstrated the effective permittivity and permeability. Moreover, the parametric study of the resonators, dielectric layer, and multi-band topology has also been investigated. The polarization-insensitive-based metamaterial may be utilized to improve the efficiency of different devices in the visible range. Furthermore, we have calculated the absorption of the proposed MPA under the solar radiation (AM1.5) for different structural parameters. The proposed absorber greatly enhances the conversion efficiency which is highly useful for solar cells. We also determined the short circuit current density of this absorber for different thicknesses of the GaAs layer. Al metal patches at meta-surface provide nearly similar performance in comparison with other costly metals. Therefore, the proposed structure with cheaper Al metal may be used for different devices as the perfect absorber.
m1A RNA Methylation Regulators Contribute To Malignant Progression And Have Clinical Prognostic Impact In Gliomas
Authors: Sun Hengchang , Gong Jiao , Shang Mei , Chen Yaqiong , Chen Jiahao , Chen Hongping , Li Zhaoxia , Hu Bo
Published: June 2021

Background Glioma is the majority of primary malignant brain tumors in adults, accounting for over 70% of malignant brain tumors. RNA modification has been proved to be closely related to the development of various carcinomas including glioma. N1-methyladenosine (m1A) is a crucial and newly validated posttranscriptional modification in RNA. Its influence on glioma is still under elucidation. Results Gene expression and clinicopathological data of glioma were downloaded from TCGA and CGGA databases. The m1A regulators’ gene expression and its relationship with tumor malignancy grade or IDH mutation or 1p19q co-deletion status in glioma, as well as its related signaling pathway were investigated. We found that m1A regulators were dysregulated and positively associated with the WHO grade of glioma. The YTHDF2 expression was associated with the overall survival rate of glioma patients and was significantly lower in IDH mutation and the 1p/19q codeletion group. YTHDF2 mainly involved in RNA splicing, mRNA processing functions, or cell cycle relate pathways in glioma. Conclusion This study elucidated the dysregulation of m1A regulators and its potential signaling pathways in glioma, which will contribute to the further understanding of m1A RNA modification in glioma.
TPH1 Gene Polymorphism (rs211105) Influences Serotonin and Tryptophan Hydroxylase 1 Concentrations in Acute Pancreatitis Patients
Authors: Snarska Jadwiga , Fiedorowicz Ewa , Rozmus Dominika , Wroński Konrad , Latacz Maria , Kordulewska Natalia , Płomiński Janusz , Grzybowski Roman , Savelkoul Huub F.J. , Kostyra Elżbieta , Cieślińska Anna
Published: June 2021

Background: The role of serotonin and its metabolic pathway in the proper functioning of the pancreas has not been thoroughly investigated yet in the aspect of AP (acute pancreatitis). Tryptophan hydroxylase (TPH) as the rate-limiting enzyme of serotonin synthesis has been considered for possible associations in various diseases. Single-nucleotide polymorphisms (SNPs) in TPH genes have been already described in associations with psychiatric and digestive system disorders. Aim of this study was to explore association of rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. Results: To date, we have found an association between the presence of the T allele at the position rs211105 (OR = 2.47, 95% CI: 0.94-6.50, p = 0.06) under conditions of a decreased AP incidence. For TT and GT genotype in control group, the lowest concentration of TPH was associated with higher serotonin levels (TT: Rs=-0.415, p=0.0018; GT: Rs=-0,457, p=0.0066), while for AP group: the highest levels of TPH among TT genotype were associated with lower levels of serotonin (TT: Rs=-0.749, p=0.0000), and in GG genotype higher levels of TPH were associated with higher levels of serotonin (GG: Rs=-0.738, p=0.037).Conclusions: Here, the new insight of the potential role of selected genetic factor in pancreatitis development was brought. Not only the metabolic pathway of serotonin, but also factors affecting serotonin synthesis may be interesting and important point in acute pancreatitis.