bluuebunny/crossref_metadata_2025 huggingface dataset:
The Size-Dependent Photonic Characteristics of Colloidal-Quantum-Dot-Enhanced Micro-LEDs
Authors: Liang Kai-Ling , Kuo Wei-Hung , Lin Chien-Chung , Fang Yen-Hsiang
Published: March 2023

Colloidal CdSe/ZnS quantum dots (QD) enhanced micro-LEDs with sizes varying from 10 to 100 μm were fabricated and measured. The direct photolithography of quantum-dot-contained photoresists can place this color conversion layer on the top of an InGaN-based micro-LED and have a high throughput and semiconductor-grade precision. Both the uncoated and coated devices were characterized, and we determined that much higher brightness of a QD-enhanced micro-LED under the same current level was observed when compared to its AlGaInP counterpart. The color stability across the device sizes and injection currents were also examined. QD LEDs show low redshift of emission wavelength, which was recorded within 1 nm in some devices, with increasing current density from 1 to 300 A/cm2. On the other hand, the light conversion efficiency (LCE) of QD-enhanced micro-LEDs was detected to decrease under the high current density or when the device is small. The angular intensities of QD-enhanced micro-LEDs were measured and compared with blue devices. With the help of the black matrix and omnidirectional light emission of colloidal QD, we observed that the angular intensities of the red and blue colors are close to Lambertian distribution, which can lead to a low color shift in all angles. From our study, the QD-enhanced micro-LEDs can effectively increase the brightness, the color stability, and the angular color match, and thus play a promising role in future micro-display technology.
Characterization of the Physical Chemistry Properties of Iron-Tailing-Based Ceramsite
Authors: Hua Shaoguang , Wu Dun , Wu Jian , Li Shuqin , Liu Guijian , Pei Dejian
Published: March 2023

In order to deal with the problems of resource waste and environmental pollution caused by solid waste, iron tailings (mainly SiO2, Al2O3 and Fe2O3) were used as the main raw material to create a type of lightweight and high-strength ceramsite. Iron tailings, dolomite (industrial grade, purity 98%) and a small amount of clay were combined in a N2 atmosphere at 1150 °C. X-ray fluorescence spectrometry (XRF), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and a themogravimetric analysis (TGA) were performed and the specific surface area was analyzed to determine the strength and adsorption of the ceramsite. The results of the XRF showed that SiO2, CaO and Al2O3 were the main components of the ceramsite, with MgO and Fe2O3 also included. The results of the XRD and SEM-EDS showed that the ceramsite contained several kinds of minerals and was mainly composed of akermanite, gehlenite and diopside, and that the morphology of the internal structure of the ceramsite was mainly massive and contained a small number of particles. The ceramsite could be used in engineering practice to improve the mechanical properties of materials and meet the requirements of actual engineering for the strength of materials. The results of the specific surface area analysis showed that the inner structure of the ceramsite was compact and that there were no large voids. The voids were mainly medium and large, with a high stability and strong adsorption ability. The TGA results showed that the quality of the ceramsite samples will continue to increase within a certain range. According to the XRD experimental results and experimental conditions, it was speculated that in the part of the ore phase containing Al, Mg or Ca in the ceramsite, the elements underwent relatively complex chemical reactions with each other, resulting in the formation of an ore phase with a higher molecular weight. This research provides the basis of characterization and analysis for the preparation of high-adsorption ceramsite from iron tailings and promotes the high-value utilization of iron tailings for waste pollution control.
Anti-Alzheimer’s Natural Products Derived from Plant Endophytic Fungi
Authors: Zhu Juntai , Wang Zimo , Song Lixia , Fu Wanxin , Liu Li
Published: March 2023

Alzheimer’s is the most common cause of dementia worldwide and seriously affects patients’ daily tasks. Plant endophytic fungi are known for providing novel and unique secondary metabolites with diverse activities. This review focuses primarily on the published research regarding anti-Alzheimer’s natural products derived from endophytic fungi between 2002 and 2022. Following a thorough review of the literature, 468 compounds with anti-Alzheimer’s-related activities are reviewed and classified based on their structural skeletons, primarily including alkaloids, peptides, polyketides, terpenoids, and sterides. The classification, occurrences, and bioactivities of these natural products from endophytic fungi are summarized in detail. Our results provide a reference on endophytic fungi natural products that may assist in the development of new anti-Alzheimer’s compounds.
Catalyst-Support Interactions Promoted Acidic Electrochemical Oxygen Evolution Catalysis: A Mini Review
Authors: Luo Zijie , Wang Jia , Zhou Wei , Li Junsheng
Published: March 2023

In the context of the growing human demand for green secondary energy sources, proton-exchange membrane water electrolysis (PEMWE) is necessary to meet the high-efficiency production of high-purity hydrogen required for proton-exchange membrane fuel cells (PEMFCs). The development of stable, efficient, and low-cost oxygen evolution reaction (OER) catalysts is key to promoting the large-scale application of hydrogen production by PEMWE. At present, precious metals remain irreplaceable in acidic OER catalysis, and loading the support body with precious metal components is undoubtedly an effective strategy to reduce costs. In this review, we will discuss the unique role of common catalyst-support interactions such as Metal-Support Interactions (MSIs), Strong Metal-Support Interactions (SMSIs), Strong Oxide-Support Interactions (SOSIs), and Electron-Metal-Support Interactions (EMSIs) in modulating catalyst structure and performance, thereby promoting the development of high-performance, high-stability, low-cost noble metal-based acidic OER catalysts.
Phytochemicals, Antioxidant and Antimicrobial Potentials and LC-MS Analysis of Centaurea parviflora Desf. Extracts
Authors: Hechaichi Fatima Zohra , Bendif Hamdi , Bensouici Chawki , Alsalamah Sulaiman A. , Zaidi Boutheina , Bouhenna Mustapha Mounir , Souilah Nabila , Alghonaim Mohammed I. , Benslama Abderrahim , Medjekal Samir , Qurtam Ashraf A. , Miara Mohamed Djamel , Boufahja Fehmi
Published: March 2023

Centaurea parviflora (C. parviflora), belonging to the family Asteraceae, is an Algerian medicinal plant used in folk medicine to treat different diseases related to hyperglycemic and inflammatory disorders, as well as in food. The present study aimed to assess the total phenolic content, in vitro antioxidant and antimicrobial activity and phytochemical profile of the extracts of C. parviflora. The extraction of phenolic compounds from aerial parts was conducted using solvents of increasing polarity starting from methanol, resulting in crude extract (CE), to chloroform extract (CHE), ethyl acetate extract (EAE) and butanol extract (BUE). The total phenolic, flavonoid and flavonol contents of the extracts were determined using the Folin–Ciocalteu and AlCl3 methods, respectively. The antioxidant activity was measured with seven methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, galvinoxyl free-radical-scavenging test, 2,2′-Azino-Bis(3-Ethylbenzothiazoline-6-Sulfonic Acid) (ABTS) assay, cupric reducing antioxidant capacity (CUPRAC), reducing power, Fe+2-phenanthroline reduction assay and superoxide-scavenging test. The disc-diffusion method aimed at testing the sensitivity of bacterial strains toward our extracts. A qualitative analysis with thin-layer chromatography of the methanolic extract was performed. Moreover, HPLC-DAD-MS was used to establish the phytochemical profile of the BUE. The BUE was found to contain high amounts of total phenolics (175.27 ± 2.79 µg GAE/mg E), flavonoids (59.89 ± 0.91 µg QE/mg E) and flavonols (47.30 ± 0.51 µg RE/mg E). Using TLC, different components such as flavonoids and polyphenols were noted. The highest radical-scavenging ability was recorded for the BUE against DPPH (IC50 = 59.38 ± 0.72 µg/mL), galvinoxyl (IC50 = 36.25 ± 0.42 µg/mL), ABTS (IC50 = 49.52 ± 1.54 µg/mL) and superoxide (IC50 = 13.61 ± 0.38 µg/mL). The BUE had the best reducing power according to the CUPRAC (A0.5 = 71.80 ± 1.22 μg/mL), phenanthroline test (A0.5 = 20.29 ± 1.16 μg/mL) and FRAP (A0.5 = 119.17 ± 0.29 μg/mL). The LC-MS analysis of BUE allowed us to identify eight compounds including six phenolic acids and two flavonoids: quinic acid, five chlorogenic acid derivatives, rutin and quercetin 3-o-glucoside. This preliminary investigation revealed that the extracts of C. parviflora have a good biopharmaceutical activity. The BUE possesses an interesting potential for pharmaceutical/nutraceutical applications.
Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity: Potential Involvement of Germ-Line microRNAs
Authors: Ribas-Aulinas Francesc , Ribo Sílvia , Casas Eduard , Mourin-Fernandez Marta , Ramon-Krauel Marta , Diaz Ruben , Lerin Carles , Kalko Susana G. , Vavouri Tanya , Jimenez-Chillaron Josep C.
Published: March 2023

Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following generation through non-genomic mechanisms, with epigenetics as a plausible candidate. The pathways involved in the development of metabolic dysfunction across generations in the context of childhood obesity remain largely unexplored. We have developed a mouse model of early adiposity by reducing litter size at birth (small litter group, SL: 4 pups/dam; control group, C: 8 pups/dam). Mice raised in small litters (SL) developed obesity, insulin resistance and hepatic steatosis with aging. Strikingly, the offspring of SL males (SL-F1) also developed hepatic steatosis. Paternal transmission of an environmentally induced phenotype strongly suggests epigenetic inheritance. We analyzed the hepatic transcriptome in C-F1 and SL-F1 mice to identify pathways involved in the development of hepatic steatosis. We found that the circadian rhythm and lipid metabolic process were the ontologies with highest significance in the liver of SL-F1 mice. We explored whether DNA methylation and small non-coding RNAs might be involved in mediating intergenerational effects. Sperm DNA methylation was largely altered in SL mice. However, these changes did not correlate with the hepatic transcriptome. Next, we analyzed small non-coding RNA content in the testes of mice from the parental generation. Two miRNAs (miR-457 and miR-201) appeared differentially expressed in the testes of SL-F0 mice. They are known to be expressed in mature spermatozoa, but not in oocytes nor early embryos, and they may regulate the transcription of lipogenic genes, but not clock genes, in hepatocytes. Hence, they are strong candidates to mediate the inheritance of adult hepatic steatosis in our murine model. In conclusion, litter size reduction leads to intergenerational effects through non-genomic mechanisms. In our model, DNA methylation does not seem to play a role on the circadian rhythm nor lipid genes. However, at least two paternal miRNAs might influence the expression of a few lipid-related genes in the first-generation offspring, F1.
“What Made My Eating Disorder Worse?” The Impact of the COVID-19 Pandemic from the Perspective of Adolescents with Anorexia Nervosa
Authors: Gilsbach Susanne , Herpertz-Dahlmann Beate
Published: March 2023

(1) Background: the COVID-19 pandemic and subsequent confinements have led to a dramatic increase in anorexia nervosa (AN) in adolescent patients, whereas the effect on symptom severity and the influencing factors are not yet clear, especially not from the adolescents’ perspective. (2) Methods: from February to October 2021, 38 adolescent patients with AN completed an adjusted version of the COVID Isolation Eating Scale (CIES), a self-report questionnaire asking for ED symptomatology before and during the COVID-19 pandemic and for their experiences with remote treatment. (3) Results: patients reported a significant negative impact of confinement on ED symptoms, depression, anxiety, and emotional regulation. During the pandemic, engagement with weight and body image was related to social media, and mirror checking increased. The patients were more preoccupied with cooking recipes and had more eating-related conflicts with their parents. However, the differences in the amount of engagement with social media actively glorifying AN before and during the pandemic did not remain significant after correction for multiple comparisons. The minority of patients who received remote treatment found it to be only limitedly helpful. (4) Conclusions: from the patients’ perspective, the COVID-19 pandemic-associated confinement had a detrimental effect on the symptoms of adolescent patients with AN.
Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment
Authors: Zhong Wu , Shen Zhehao , Wang Menglan , Wang Hongyi , Sun Yuting , Tao Xiaojun , Hou Defu
Published: March 2023

Triple negative breast cancer (TNBC), which has poor prognosis, easily develops drug resistance and metastasizes. In general, those TNBC characteristics are related to a high activation of the epithelial-mesenchymal transition (EMT) pathway, which is inhibited by shikonin (SKN). Therefore, the synergistic therapy of SKN and doxorubicin (DOX) will increase anti-tumor efficacy and reduce metastasis. In this study, we prepared the folic acid-linked PEG nanomicelle (NM) grafted with the DOX (denoted as FPD) to load the SKN. We prepared the SKN@FPD NM according to the effective ratio of dual drugs, where the drug loadings of DOX and SKN were 8.86 ± 0.21% and 9.43 ± 0.13%, with 121.8 ± 1.1 nm of its hydrodynamic dimension and 6.33 ± 0.16 mV of zeta potential, respectively. The nanomaterials significantly slowed down the release of DOX and SKN over 48 h, leading to the release of pH-responsive drugs. Meanwhile, the prepared NM inhibited the activity of MBA-MD-231 cells in vitro. Further in vitro study revealed that the SKN@FPD NM increased the DOX uptake and significantly reduced the metastasis of MBA-MD-231 cells. Overall, these active-targeting NMs improved the tumor-targeting of small molecular drugs and effectively treated TNBC.
A Multi-Layered 3D NDT Scan-Matching Method for Robust Localization in Logistics Warehouse Environments
Authors: Kim Taeho , Jeon Haneul , Lee Donghun
Published: March 2023

This paper proposed a multi-layered 3D NDT (normal distribution transform) scan-matching approach for robust localization even in the highly dynamic environment of warehouse logistics. Our approach partitioned a given 3D point-cloud map and the scan measurements into several layers regarding the degree of environmental changes in the height direction and computed the covariance estimates for each layer using 3D NDT scan-matching. Because the covariance determinant is the estimate’s uncertainty, we can determine which layers are better to use in the localization in the warehouse. If the layer gets close to the warehouse’s floor, the degree of environmental changes, such as the cluttered warehouse layout and position of boxes, would be significantly large, while it has many good features for scan-matching. If the observation at a specific layer is not explained well enough, then the layer for localization can be switched to other layers with lower uncertainties. Thus, the main novelty of this approach is that localization robustness can be improved even in very cluttered and dynamic environments. This study also provides the simulation-based validation using Nvidia’s Omniverse Isaac sim and detailed mathematical descriptions for the proposed method. Moreover, the evaluated results of this study can be a good starting point for further mitigating the effects of occlusion in warehouse navigation of mobile robots.
UWB Frequency-Selective Surface Absorber Based on Graphene Featuring Wide-Angle Stability
Authors: Wang Zhefei , Huang Jiajun , Sun Dongjiao , Zeng Qingsheng , Song Mingxin , Denidni Tayeb A.
Published: March 2023

In this paper, an ultra-wideband and polarization-insensitive frequency-selective surface absorber is presented with oblique incident stable behavior. Different from conventional absorbers, the absorption behavior is much less deteriorated with the increase in the incidence angle. Two hybrid resonators, which are realized by symmetrical graphene patterns, are employed to obtain the desired broadband and polarization-insensitive absorption performance. The optimal impedance-matching behavior is designed at the oblique incidence of electromagnetic waves, and an equivalent circuit model is used to analyze and facilitate the mechanism of the proposed absorber. The results indicate that the absorber can maintain a stable absorption performance with a fractional bandwidth (FWB) of 136.4% up to 40°. With these performances, the proposed UWB absorber could be more competitive in aerospace applications.
Fast and Accurate Gamma Imaging System Calibration Based on Deep Denoising Networks and Self-Adaptive Data Clustering
Authors: Zhu Yihang , Lyu Zhenlei , Lu Wenzhuo , Liu Yaqiang , Ma Tianyu
Published: March 2023

Gamma imagers play a key role in both industrial and medical applications. Modern gamma imagers typically employ iterative reconstruction methods in which the system matrix (SM) is a key component to obtain high-quality images. An accurate SM could be acquired from an experimental calibration step with a point source across the FOV, but at a cost of long calibration time to suppress noise, posing challenges to real-world applications. In this work, we propose a time-efficient SM calibration approach for a 4π-view gamma imager with short-time measured SM and deep-learning-based denoising. The key steps include decomposing the SM into multiple detector response function (DRF) images, categorizing DRFs into multiple groups with a self-adaptive K-means clustering method to address sensitivity discrepancy, and independently training separate denoising deep networks for each DRF group. We investigate two denoising networks and compare them against a conventional Gaussian filtering method. The results demonstrate that the denoised SM with deep networks faithfully yields a comparable imaging performance with the long-time measured SM. The SM calibration time is reduced from 1.4 h to 8 min. We conclude that the proposed SM denoising approach is promising and effective in enhancing the productivity of the 4π-view gamma imager, and it is also generally applicable to other imaging systems that require an experimental calibration step.
Barriers to the Adoption of Innovations for Sustainable Development in the Agricultural Sector—Systematic Literature Review (SLR)
Authors: Campuzano Laura Restrepo , Hincapié Llanos Gustavo Adolfo , Zartha Sossa Jhon Wilder , Orozco Mendoza Gina Lía , Palacio Juan Carlos , Herrera Mariana
Published: March 2023

In this article, we focused on studying the current barriers to implementing innovations in order for the agricultural sector to become more sustainable. Through a systematic literature review (SLR), 73 scientific articles were obtained with a search equation in SCOPUS. Of these, 48 were analyzed because of the mention of an obstacle preventing the sector from implementing innovations towards sustainability. Information related to the publication year, abstract, authors, keywords, innovation, innovation type, relationship with Fourth Industrial Revolution (4IR), identified barrier, nature of the barrier (internal/external), agricultural subsector, country, and methodology of each article was identified, and with VantagePoint software, a technological surveillance technique was applied as a quantitative analysis of the information. The United States is the country with the most publications related to the subject. The most mentioned keywords were “Sustainable Agriculture”, “Agroecology”, “Climate Change”, “Innovation”, and “Organic Farming”. Additionally, a qualitative analysis showed 43 types of innovations, 16 of them related to technology. “Organic Agriculture” is the most mentioned innovation, followed by “Genetic Engineering” and “Precision Agriculture”. In addition, 51 barriers were identified, 28 external to farmers and 23 internal. “Lack of policies that promote that innovation Innovative Practices” is the most mentioned barrier, followed by “Epistemic Closure”, “Unfavorable Regulation”, Climate-Smart Agriculture, and “Unskilled Labor”. This article is intended not only to show trends in the barriers to innovation that prevents the achievement of sustainability that the agricultural sector needs, but also to serve as an input for the development of policies that provide solutions to these impediments. It was shown that 17 out of the 28 external barriers are related to topics that could be solved by formulating policies, laws, incentives, guidelines, and regulations.
Water Disconnection and Vital Flow Policies: International Practices in Medium- and High-Income Countries
Authors: Marques Rui Cunha , Simões Pedro , Machete Inês , Fagundes Thalita
Published: March 2023

Water access is recognized as a human right by the United Nations since 2010. However, even when piped water is available, the economic crisis has limited poorer households to afford those services on a regular basis. Users become debtors as utilities face growing service costs and shrinking national public funds, pushing tariffs as the main source of revenue for cost recovery. The COVID-19 pandemic lit up affordability issues and health consequences of disconnection policies. Countries worldwide banned water shutoffs during the last year, ensuring water and wastewater service access for all citizens. Although disconnection is a way to reduce the number of debtors, it is, at the same time, considered a threat to human rights statements. This study gathered information on water subsidies, disconnection and vital flow policies applied among several medium- and high-income countries, in order to analyze how utilities have dealt with default rates and if there is any difference between the approaches between medium- and high-income countries. Through case studies, this paper also aims to inspire other practitioners facing the same issues. Based on the eleven case studies presented here, we concluded that high-income countries use assistance programs over water disconnection policies when compared to medium-income ones. Water shutoffs are explicitly forbidden in the United Kingdom, Australia, and France. Although a humane alternative, water flow restrictors have limited application, especially considering the technical issues involved.
Analysis of the Effect of the Use of Food Waste Disposers on Wastewater Treatment Plant and Greenhouse Gas Emission Characteristics
Authors: Kim Dowan , Phae Chaegun
Published: March 2023

The introduction of food waste disposers (FWDs) has been discussed in various countries, and in Korea, a method for utilizing FWDs has been considered. The results of the study show that the use of FWDs is more eco-friendly and economical than other forms of food waste (FW) disposal. However, there are also studies showing that FWDs are worse, for example, they aggravate water pollution and deteriorate the function of municipal wastewater treatment plants (WWTPs). Therefore, this study analyzed the concentration of pollutants of wastewater from FWD and the effect on the operation rate and GHG emission of WWTP when FW was introduced into the sewer by FWD using operation data for each WWTP. As a result of the analysis, when FWD was used, facilities exceeding the appropriate operation rate accounted for 86% of the total WWTP, and net-GHG emissions increased by 58%. Through this, FWD wastewater showed much higher contaminant concentrations than regular wastewater; thus, the introduction of FWD in the current situation will have a negative effect on maintaining the function of WWTP and reducing GHG. To introduce FWDs, improvement in WWTPs regarding pollutant load and discharge characteristics of FW and input of digestion systems through a separate FWD pipe, the introduction of high-efficiency energy facilities, and the recycling of wastewater sludge are necessary to reduce GHG emissions.
Application of Drifted Pumice Stone as a Sand-Capping Material
Authors: Inoue Tetsunori , Fujita Isamu
Published: March 2023

Large amounts of pumice stone generated by the submarine volcanic eruption at Fukutoku Okanoba on 13 August 2021 drifted ashore, affecting ship navigation and fishery operations and posing challenges for disposal and a risk to benthic sea-life. As a new approach to managing ejected pumice from submarine eruptions, we investigated the possibility of using pumice as a sand-capping material for eutrophic sediments through laboratory experiments. Crushed pumice as a sand cover material effectively reduced the sedimentary oxygen consumption rate. Nutrient release from sediment showed a similar trend, with ~25% and 82% reductions in NH4-N and PO4-P release rates, respectively. Furthermore, bivalve exposure experiments using crushed pumice suspended in seawater showed no adverse effects specific to pumice and lowered bivalve mortality to a greater extent than did using kaolin at the same concentration. This could be related to the differences in gill accumulation and blockage owing to the particle size variation of suspended particles. These results suggest that crushed pumice is effective for sand-capping and suitably suppresses oxygen consumption and nutrient release from sediments.
Folklore as an agent of heroic and patriotic education of a personality
Authors:   Department of History, Law and Humanitarian Disciplines, North Caucasian Institute - Branch of the Russian Presidential Academy of National Economy and Public Administration, Pyatigorsk, Mullyar Liliya Anatolievna
Published: March 2023

The article analyzes folklore as an integral part of the national consciousness and a direct expression of the mentality of the social community, as well as substantiates the pedagogical patriotic potential of folklore - a heroic fairy tale and a heroic epic. Russian fairytale and epic culture is characterized as a precedent for patriotic content and, therefore, an agent for the formation of a model of a patriotic worldview.
Vacation at your own expense
Authors:   Pepelyaev Group Law Company, Moscow, Zhizherina Yu.Yu.
Published: March 2023

All employers face leave without pay, so in most cases, processing the provision of such leave is not a difficult process. However, when applying for a vacation at your own expense, there may be nuances. For example, is it legal to send workers on leave at your own expense due to the complication of the economic situation in order to reduce staff costs? In what situations can workers take leave without pay without coordinating such leave with the employer? How does non-pay leave affect seniority to calculate annual leave and leave compensation? How to properly arrange a vacation without pay? There are other issues surrounding the provision of leave without pay. Consider all these questions in the article.
Modern possibilities of working with electronic personnel documents at railway transport enterprises
Authors:   Department of ", Lebedev M.S. ,   Personnel Management and Sociology",   , Ural State University of Railway Transport, Yekaterinburg
Published: March 2023

Modern possibilities of electronic personnel document management at railway transport enterprises are described. The author presents a list of HR documents of JSCo Russian Railways, in respect of which electronic document management is carried out, corporate electronic systems and operating programs used in the Company to ensure electronic document management are listed. It is concluded that it is advisable and necessary to use electronic personnel documents in the process of managing personnel of a railway transport enterprise.
Flour quality management
Authors:   Group of companies ", Ruslyakov V.A. ,   Rosmiks",   Saint Petersburg
Published: March 2023

This article is devoted to the study of issues related to the quality indicators of raw materials for the production of flour. The issue of a global problem related to the factors of the use of low-quality food raw materials and food products necessary for the preservation of human health is touched upon. The definition of the concept of quality is given, which includes the effectiveness of absolutely all aspects of activity. It is noted that in order to ensure the favorable flow of all technical processes, it is worth using high-quality raw materials. The parameters that are used to determine the quality of flour are summarized. Special attention was paid to the technical process of flour production. It is noted that the structural and mechanical properties of grain determine the quality and yield of flour. The divisions of wheat into hard-grain and soft-grain are considered. The analysis of the use of each type of wheat was carried out. It is also noted that excessive grinding of flour in a vibrating mill has a negative impact on baking properties, which leads to a sharp deterioration in the quality of bread. The importance of grinding rollers affecting the quality parameters of the product produced by roller mills is noted. The main qualitative indicators of flour are determined. The indicators of the study of the effect of the gaps between the rollers of 1-3 grinding systems on the VPS of flour from grains of different hardness are considered. Based on the results obtained, the kinetics of the rheological characteristics of wheat dough during kneading was obtained, reflecting the change in the stability of the dough and its liquefaction, as well as the water absorption capacity of flour, depending on the size of the gap between the rollers. The article also defines the main criteria for the quality and properties of flour, which directly depend on chemical and biochemical processes. Which, in turn, control aging and maturation. Based on this, the importance of organizing the storage process is touched upon, which is one of the most important factors that ensures the safety of the quality of the finished product. There are certain requirements for the characteristics of the packaging material, as well as for the transportation process to ensure the safety of flour and cereal products.
Beer labeling is planned to begin on April 1, 2023
Authors:   CS Rostest Ural, Kurbatova E.D.
Published: March 2023

On April 1, 2023, mandatory labeling of beer will start working in Russia. The article presents how the new labeling system will work and what requirements manufacturers need to comply with in the new conditions.
Analisis Kepuasan Konsumen terhadap Loyalitas Konsumen dengan Dimoderasi oleh Faktor Harga dan Variasi Produk Makanan Sehat pada PT Melia Sehat Sejahtera
Authors: Nasution Amrin Mulia Utama
Published: March 2023

Many providers in Indonesia currently have many products such as PT Melia Sehat Sejahtera. The success of product development has made PT Melia Sehat Sejahtera a well-known  in Indonesia. The many awards this  has won has made PT Melia Sehat Sejahtera always be number one thanks to the level of customer loyalty. Consumer loyalty according to behavioral understanding is consistent with repurchasing behavior as well as a measure of customer preference to repurchase and the tendency to switch to the product. Repurchase intention is strongly influenced by consumer satisfaction with a product. However, there are two studies which state that it has a negative effect on consumer loyalty, so that a moderating variable appears. This research was tested on 133 respondents who then collected the data and tested its feasibility. After the feasibility test, a data analysis test was carried out using SEM (regression) with the help of the SmartPLS program. This study resulted in the following conclusions 1) The strong role of consumer satisfaction (93%) on consumer loyalty at PT Melia Sehat Sejahtera, because PT Melia Sehat Sejahtera is a highly recommended place to eat with its food choices, PT Melia Sehat Sejahtera is also easy to get, with many branches in each region make it easier for consumers to buy PT Melia Sehat Sejahtera products. 2) Consumer satisfaction which is moderated by the price of PT Melia Sehat Sejahtera's  products has a relatively small effect (1%) on consumer loyalty and price can also play a direct negative role (-1.3%) on consumer loyalty. This is because the price is competitive compared to similar products. 3) The role of the relatively small level of consumer satisfaction (8%) is moderated by product variations on  consumer loyalty at PT Melia Sehat Sejahtera and product variety can play a direct role on consumer loyalty by (5%). This is due to the lack of variety of PT Melia Sehat Sejahtera's  products.
Plantar, colher e formar: práticas sustentáveis e permaculturais em uma escola do interior paulista
Authors: Paro Emilyn , Massabni Vânia Galindo
Published: March 2023

A Educação Ambiental (EA) é princípio e ferramenta para reverter os efeitos da crise gerada pelas ações antrópicas e à escola cabe a reflexão sobre o modelo de sociedade que se quer para o futuro. Assim, buscou-se compreender as percepções sobre Educação Ambiental e atitudes sustentáveis em uma escola de período integral que possui trabalhos sobre permacultura, um modo de agricultura sustentável. Foram aplicados questionários a alunos, professores e funcionários desta escola em fases distintas, adaptados para cada um destes públicos. Notou-se o distanciamento entre o desejado e praticado, embora muitos indiquem ter atitudes sustentáveis.
Descarte de resíduos sólidos em aldeias indígenas de Roraima: alternativas e soluções para o saneamento rural
Authors: Bezerra Giovana Adélia Ausier Oliveira , Wankler Fábio  Luiz
Published: March 2023

Este artigo discute os resultados das observações feitas durante uma visita in loco, em outubro de 2021 nas aldeias indígenas Parima e Makabey da Terra Indígena Yanomami, Roraima, com foco no manejo de resíduos sólidos. Identificou-se  produtos com embalagens e substâncias não biodegradáveis e substâncias com alto potencial de contaminação, cujo descarte ocorre por queima ou dispersão errática no solo, o que favorece aparecimento de vetores e doenças e degradação ambiental. Concluiu-se é necessário um protocolo apropriado para o manejo aplicável nestes ambientes de difícil acesso, mas só será efetiva com a participação comunitária e melhoria percepção ambiental da comunidade através da Educação Ambiental.
Desenvolvimento de propostas pedagógicas para Educação Ambiental de alunos do ensino médio
Authors: Pereira Graciane Regina , Zucchi Daniela , Pereira Junior Eraldo Isidio , Lanser Rafael Ademar
Published: March 2023

A Educação Ambiental é um tema transversal obrigatório em toda a trajetória da educação formal, porém, na prática, sua inserção ainda é incipiente e os materiais didáticos de apoio são dispersos e escassos, em especial para o ensino médio. Nesse cenário, desenvolveram-se propostas pedagógicas de Educação Ambiental para o ensino médio, utilizando metodologias acessíveis e inovadoras, consoantes com as novas diretrizes da educação básica do país e do Estado de Santa Catarina. As atividades foram definidas no âmbito de cinco temáticas: água; saúde e alimentação; produção e consumo; energia; ciência e tecnologia; e direitos humanos. O compilado das propostas constituiu uma publicação, disponibilizada em formato digital, para ser usada por professores que atuem no ensino médio.
Arpenter les pays d'oïl. Chronique de la crise Covid
Authors: Bing Jean-Baptiste
Published: March 2023

Durant près de deux ans, les restrictions de déplacement liées à la crise sanitaire du Covid-19 ont été l'occasion d'inventer des stratégies pour préserver, dans une optique géopoétique, un rapport autonome à l'espace et au temps. Cet article croise ainsi l'usage : des richesses des langues locales d'oïl ; de l'imagination comme expérience de pensée ; et de la conjugaison de l'histoire et de l'arpentage concret des lieux comme double épreuve du réel. En émerge une territorialité mouvante, nourrie par une dynamique topologique et par une identité fluide.
Flâneries florales dans le Pays grassois
Authors: Marengo Marina
Published: March 2023

From literary and television representations, as well as personal strolls in the Pays de Grasse, we reconstruct the international, and yet very local, course of the perfume and aroma industry in Grasse, as well as the tradition of growing perfume flowers in the region is highlighted.
Ruanda, 28 años después del genocidio: ¿hacia dónde camina el país?
Authors: Firmin Dusabe
Published: March 2023

El exterminio sistemático con la intención de destruir los tutsis ruandeses, sucedido en 1994, sitúa a Ruanda entre los genocidios del siglo XX junto al Holocausto de los judíos, el genocidio armenio, el genocidio camboyano y el genocidio en Bosnia. Entre el 7 de abril y julio de 1994, en sólo doce semanas, alrededor de un millón de personas, casi todas tutsis, fueron sistemáticamente asesinadas. También sucedió el asesinato de hutus moderados, familiares y amigos de tutsis. Todo esto causó la ruptura de la sociedad ruandesa, la desconfianza entre la gente y la destrucción del país a todos los niveles. Es interesante analizar hacia dónde camina el país después de 25 años del genocidio.
Estudo sobre a viabilidade de aplicação do veículo elétrico na Polícia Militar do Paraná
Authors: Galeski Alessandro
Published: March 2023

Frente aos avanços tecnológicos decorrentes das questões ambientais, este artigo apresenta uma análise da futura aplicação de viaturas com propulsão diversa da matriz petróleo/etanol, com ênfase no veículo elétrico e suas variações híbridas, conforme a tendência atual, trazendo a experiência de outras Polícias Militares do Brasil, bem como, a aplicação em países da Europa e da América do Norte. A análise foi realizada com base em relatórios e trabalhos científicos sobre o tema, bem como, conceitos de autores na área da engenharia. A pesquisa, fundamenta-se no método indutivo, com a utilização da técnica de análise de dados produzidos em relatórios, material bibliográfico e artigos científicos. O resultado de um teste com veículos elétricos realizado na Polícia Militar do Estado de São Paulo foi esmiuçado na presente pesquisa, sendo apresentados os resultados de custos, local de utilização e desempenho. Experiências de outros estados e países foram apresentadas, com a intenção de que o conjunto de informações subsidiem estudos futuros para a busca de alternativas à provável substituição do combustível fóssil/etanol, face a tendência mercadológica atual.
Imunoviroterapia oncolítica com Herpesvírus Simplex tipo I em tumores cerebrais malignos
Authors: Guamarrigra Lenín Patricio Maldonado , Portilla Cristian Carlos Ramirez , Villalta José David Andrade , Aucay Homero Abel Chacho
Published: March 2023

Os ensaios pré-clínicos e clínicos com vírus oncolíticos para o tratamento de tumores sólidos difíceis de gerir, tais como tumores cerebrais, provaram ser melhores do que os tratamentos convencionais. Especialmente para o glioblastoma (GB), um tumor cerebral com prognóstico e tratamento sombrios, são investigadas diferentes variantes do herpesvirus simplex tipo I e utilizadas para melhorar a sobrevivência a longo prazo. Objectivo: descrever a imunoviroterapia oncolítica com vírus do herpesvírus simplex tipo 1 como um agente imunitário e perturbador lítico em tumores cerebrais malignos. Método: a investigação é uma revisão abrangente dos artigos publicados entre 2013 e 2022, utilizando a estratégia PICO que integrou a questão da investigação. A pesquisa de informação foi realizada a partir de fontes de dados Pubmed e ScienceDirect, utilizando descritores e os operadores Booleanos AND e OR. Resultados: O vírus Herpes simplex tipo I confere particularidades cognatas para a matança de células cancerosas e cria imunidade inata e adaptativa contra células tumorais em cancros cerebrais em crianças e adultos.
A influência das mídias e redes sociais na saúde mental dos jovens
Authors: Santos Isabela Vieira Pereira , Amâncio Natália de Fátima Gonçalves , Romão Mariluce Ferreira , De Almeida Karine Cristine
Published: March 2023

O presente artigo relata como o fenômeno das mídias sociais impactam no surgimento de transtornos psicológicos. O objetivo do estudo foi analisar diferentes artigos que discutiram a influência da internet sobre a saúde mental dos adolescentes. A metodologia trata-se de uma revisão de literatura de 18 publicações no período de 2018 a 2022, encontradas nas seguintes bases de dados: Biblioteca Virtual de Saúde (BVS), Scientif Eletronic Library Online (SciELO), National Library of Medicine (PubMed), EbscoHost e Google Schoolar. Após a análise dos textos, foi possível identificar que as mídias digitais podem impactar os indivíduos de diferentes maneiras. Os resultados demonstraram que a maioria dos estudos comprovam uma relação direta entre o adoecimento mental e o uso excessivo de mídias digitais. Constatou-se que, devido a isso o fenômeno das redes sociais impacta em maior escala os jovens, visto que, estes, são os que mais desfrutam dessa tecnologia. Consequentemente, baseadas nas evidências encontradas é de suma importância a execução de ações preventivas por profissionais da saúde, como na área da Psiquiatria e Psicologia.
Intervenção precoce no tratamento de crianças do Espectro Autista
Authors: Gomes Lorenna Bezerra , De Sousa Milena Nunes Alves
Published: March 2023

Objetivo: Analisar a eficácia da intervenção precoce no tratamento de crianças com transtorno do espectro autista (TEA).Métodos: A pesquisa se fundamentou no método de Revisão Sistemática da Literatura. Em decorrência de suas peculiaridades, esta revisão contemplou as seguintes etapas:elaboração da pergunta de pesquisa (Em crianças com transtorno do espectro autista, a intervenção precoce é eficaz para a melhora do quadro clínico?); busca na literatura;seleção dos artigos; extração dos dados; avaliação da qualidade metodológica; síntese dos dados; avaliação da qualidade das evidências; redação e publicação dos resultados.Inicialmente, foram encontrados 28 artigos,porém, somente 10 se encaixaram nos critérios de inclusão e exclusão.Resultados: Dentre os 10 artigos selecionados,20% indicam a melhor idade para que a intervenção aconteça,70% abordam sobre a eficácia da intervenção precoce, contudo, 10% estabelecem que a mesma não tem eficácia bem definida.Conclusão: Os estudos demonstraram, na maioria, que a intervenção precoce resultou em melhorias significativas das funções cognitivas e comportamentais das crianças acometidas peloTEA.
Detecção molecular de Anaplasma platys em pulgas de gatos – nota de pesquisa
Authors: Coelho Willian Marinho Dourado , Cardoso Andrey Maciel , De Freitas João Felipe Azambuja , Fonzar José Francisco , Nogueira Fábio dos Santos , Gomes Cássia Regina de Avelar , Bresciani Katia Denise Saraiva
Published: March 2023

Relatamos neste estudo a primeira descrição da detecção molecular de Anaplasma platys em pulgas do gênero Ctenocephalides felis. Os ectoparasitos foram coletados manualmente de gatos provenientes da cidade de Andradina, estado de São Paulo. As pulgas foram acondicionadas em potes plásticos e armazenadas à -20 graus Celsius até o momento da análise por meio da técnica de Reação em Cadeia da Polimerase (PCR). Amplificação positiva para Anaplasma platys foi obtida em 100% das amostras. Esta pesquisa aponta o resultado inédito da infecção natural pela bactéria causadora da trombocitopenia cíclica infecciosa canina em pulgas coletadas de gatos.
Uso de los nuevos anticoagulantes orales en el síndrome antifosfolipidico: revisión bibliográfica
Authors: Iñiguez Mateo Nicolás Andrade , Espinoza Esteban Adrián Reibán , Ortiz Kevin Sebastian Criollo , Di Rosa Rebeca Rodríguez , Vivar María Angélica Córdova , Caraguay Sarahí Alejandra Vergara , Sanmartín Fausto Andrés Martínez , Lanzarin Ana Lara Braga
Published: March 2023

Antecedentes. El síndrome antifosfolipídico es considerado a nivel mundial la trombofilia adquirida más abundante, con una prevalencia de 40 a 50 casos por cada 100.000 habitantes en general, con mayor predisposición en mujeres, con una relación 5:1 en contraste con pacientes varones. El tratamiento alternativo utilizado para esta patología en la última década se basa en la anticoagulación mediante anticoagulantes orales directos (ACOD), los cuales presenta una eficacia similar frente a los anticoagulantes tradicionales como las heparinas de bajo peso molecular (HBPM)  o los antagonistas de la vitamina K (AVK), esta nueva terapéutica resulta muy atractiva, debido a que no se requiere monitorización, posee menos interacciones con otros fármacos o alimentos, se prescriben en una dosis fija con un efecto anticoagulante más predecible, un inicio de acción rápida, con lo que se pretende mejorar la calidad de vida de los pacientes. Metodología. El presente estudio es una revisión bibliográfica de tipo Scoping review con metodología PRISMA utilizando las bases de datos SCOPUS, PUBMED y WEB OF SCIENCE a través de descriptores bibliográficos con la utilización de palabras clave aplicando criterios de elegibilidad de inclusión y exclusión. Objetivo. Describir el uso de los nuevos anticoagulantes orales directos en el síndrome antifosfolipídico. Discusión y Resultados. Con un total de 16 artículos seleccionados se demostró que el uso de los nuevos anticoagulantes orales en la prevención secundaria es igual de efectiva a comparación de los anticoagulantes clásicos Conclusión. Los ACOD brindan características que pretenden brindar una mejorar calidad de vida de los pacientes sin embargo solo se recomienda en la proxifalis secundaria, luego de un primer evento tromboembólico y no se recomienda usar en trombosis arterial o pacientes doble o triple positivo.
Análise da cobertura vacinal no estado de Goiás entre os anos de 2018 a 2022
Authors: Martins Fernanda Franco , Soares Filho Reginaldo Dias , Borges Pyetra Silva , Da Silva Filho Natanael Isaias , Rocha Raisa D’ Ricolli Rebouças , Ribeiro Maria Paula , Silva Vitoria Japyassu , Silva Filho Daniel Rodrigues , Rodrigues Savianny Gonçalves
Published: March 2023

É evidente que a vacinação é um dos meios mais eficazes para prevenção de doenças e agravos e, por décadas, considerada uma das principais estratégias de saúde pública, sendo uma maneira de reduzir ou erradicar doenças transmissíveis. No Brasil, as primeiras campanhas de vacinação começaram no ano de 1804, e naquele momento histórico, possuíam o caráter obrigatório e compulsório. Contudo, a população criou um sentimento negativista acerca da administração vacinal, sustentando a lenda popular de que as vacinas eram pouco seguras ou armas biológicas criadas pelo governo para controle populacional. Todavia, essas lendas têm ganhado destaque nos dias atuais, interferindo negativamente no quantitativo populacional com as vacinas em dia. Nesse contexto, o presente estudo objetiva analisar a cobertura vacinal no estado de Goiás entre os anos de 2018 a 2022, a fim de entender esse panorama. Esta pesquisa trata-se de um estudo de revisão bibliográfica da literatura científica. Ademais, torna-se nítido através dos dados que a vacinação no Brasil e em Goiás tem alcançado níveis insatisfatórios de cobertura, tendo em vista que o momento atual de recorrentes notícias falsas, lendas e informações têm contribuído de forma negativa para esse processo. Logo, com o levantamento de dados sobre a vacinação no país, pode-se propor ações de promoção à saúde. Ainda, portanto, os dados obtidos pelo estudo poderá ser referência para posterior estruturação de estratégias referentes à melhoria neste âmbito.