bluuebunny/crossref_metadata_2025 huggingface dataset:
All-Semiconductor Plasmonic Resonator for Surface-Enhanced Infrared Absorption Spectroscopy
Authors: Wei Wei , Nong Jinpeng , Jiang Xiao , Chen Na , Luo Suqin , Tang Linlong
Published: January 2017

Infrared absorption spectroscopy remains a challenge due to the weak light-matter interaction between micron-wavelengthed infrared light and nano-sized molecules. A highly doped semiconductor supports intrinsic plasmon modes at infrared frequencies, and is compatible with the current epitaxial growth processing, which makes it promising for various applications. Here, we propose an all-semiconductor plasmonic resonator to enhance the infrared absorption of the adsorbed molecules. An optical model is employed to investigate the effect of structural parameters on the spectral features of the resonator and the enhanced infrared absorption characteristics are further discussed. When a molecular layer is deposited upon the resonator, the weak molecular absorption signal can be significantly enhanced. A high enhancement factor of 470 can be achieved once the resonance wavelength of the resonator is overlapped with the desired vibrational mode of the molecules. Our study offers a promising approach to engineering semiconductor optics devices for mid-infrared sensing applications.
Enhanced Visible Light Photocatalytic Activity of ZnO Nanowires Doped with Mn2+ and Co2+ Ions
Authors: Li Wei , Wang Guojing , Chen Chienhua , Liao Jiecui , Li Zhengcao
Published: January 2017

In this research, ZnO nanowires doped with Mn2+ and Co2+ ions were synthesized through a facile and inexpensive hydrothermal approach, in which Mn2+ and Co2+ ions successfully substituted Zn2+ in the ZnO crystal lattice without changing the morphology and crystalline structure of ZnO. The atomic percentages of Mn and Co were 6.29% and 1.68%, respectively, in the doped ZnO nanowires. The photocatalytic results showed that Mn-doped and Co-doped ZnO nanowires both exhibited higher photocatalytic activities than undoped ZnO nanowires. Among the doped ZnO nanowires, Co-doped ZnO, which owns a twice active visible-light photocatalytic performance compared to pure ZnO, is considered a more efficient photocatalyst material. The enhancement of its photocatalytic performance originates from the doped metal ions, which enhance the light absorption ability and inhibit the recombination of photo-generated electron-hole pairs as well. The effect of the doped ion types on the morphology, crystal lattice and other properties of ZnO was also investigated.
Nutrient Patterns Associated with Fasting Glucose and Glycated Haemoglobin Levels in a Black South African Population
Authors: Chikowore Tinashe , Pisa Pedro , Van Zyl Tertia , Feskens Edith , Wentzel-Viljoen Edelweiss , Conradie Karin
Published: January 2017

Type 2 diabetes (T2D) burden is increasing globally. However, evidence regarding nutrient patterns associated with the biomarkers of T2D is limited. This study set out to determine the nutrient patterns associated with fasting glucose and glycated haemoglobin the biomarkers of T2D. Factor analysis was used to derive nutrient patterns of 2010 participants stratified by urban/rural status and gender. Principal Component Analysis (PCA) was applied to 25 nutrients, computed from the quantified food frequency questionnaires (QFFQ). Three nutrient patterns per stratum, which accounted for 73% of the variation of the selected nutrients, were identified. Multivariate linear regression models adjusted for age, BMI, smoking, physical activity, education attained, alcohol intake, seasonality and total energy intake were computed. Starch, dietary fibre and B vitamins driven nutrient pattern was significantly associated with fasting glucose (β = −0.236 (−0.458; −0.014); p = 0.037) and glycated haemoglobin levels (β = −0.175 (−0.303; −0.047); p = 0.007) in rural women. Thiamine, zinc and plant protein driven nutrient pattern was associated with significant reductions in glycated haemoglobin and fasting glucose ((β = −0.288 (−0.543; −0.033); p = 0.027) and (β = −0.382 (−0.752; −0.012); p = 0.043), respectively) in rural men. Our results indicate that plant driven nutrient patterns are associated with low fasting glucose and glycated haemoglobin levels.
Ablation of Protein Kinase CK2β in Skeletal Muscle Fibers Interferes with Their Oxidative Capacity
Authors: Eiber Nane , Simeone Luca , Hashemolhosseini Said
Published: January 2017

The tetrameric protein kinase CK2 was identified playing a role at neuromuscular junctions by studying CK2β-deficient muscle fibers in mice, and in cultured immortalized C2C12 muscle cells after individual knockdown of CK2α and CK2β subunits. In muscle cells, CK2 activity appeared to be at least required for regular aggregation of nicotinic acetylcholine receptors, which serves as a hallmark for the presence of a postsynaptic apparatus. Here, we set out to determine whether any other feature accompanies CK2β-deficient muscle fibers. Hind limb muscles gastrocnemius, plantaris, and soleus of adult wildtype and CK2β-deficient mice were dissected, cross-sectioned, and stained histochemically by Gomori trichrome and for nicotinamide adenine dinucleotide (NADH) dehydrogenase and succinate dehydrogenase (SDH) enzymatic activities. A reduction of oxidative enzymatic activity was determined for CK2β-deficient muscle fibers in comparison with wildtype controls. Importantly, the CK2β-deficient fibers, muscle fibers that typically exhibit high NADH dehydrogenase and SDH activities, like slow-type fibers, showed a marked reduction in these activities. Altogether, our data indicate additional impairments in the absence of CK2β in skeletal muscle fibers, pointing to an eventual mitochondrial myopathy.
Moving Forward in Their Journey: Participants’ Experience of Taste & See, A Church-Based Programme to Develop a Healthy Relationship with Food
Authors: Patel Riya , Lycett Deborah , Coufopoulos Anne , Turner Andy
Published: January 2017

Quantitative evidence is beginning to document the successful outcomes achieved from holistic interventions that include a spiritual element as an approach to self-manage obesity in the community. However, qualitative research, which helps us understand the reasons behind their success, is scarce. Our aim was to explore participants’ acceptance of and engagement with the Taste & See programme. Semi-structured interviews were carried out after participants had completed the Taste & See programme. Interviews were transcribed and analysed using deductive thematic analysis. Themes showing that ‘God and food issues had been kept separate’ at the start of the programme and that participants then ‘Began to use faith as a resource’ were identified. Also, while ‘Eating freely was a challenge’ initially, participants later found ‘empowerment and enjoyment in freedom’. ‘Addressing more than just a weight problem’ was valued highly and there were benefits and difficulties that arose from ‘Coping with other group members’. The rich level of evaluation provided through this study identifies that the participants found the programme a novel experience. The intervention was acceptable and participants engaged well with the programme content.
Searching for the Hidden: A Phenomenological Study Exploring the Spiritual Aspects of Day Case Surgery from Staff Perspectives
Authors: Pike Joanne
Published: January 2017

Recent healthcare literature has shown an increasing interest in spiritual care and the way in which it supports patients as they deal with illness; but; as the body of evidence grows in many areas; the spiritual aspects of day surgery have been under-researched. The aims of this interpretive phenomenological study were to identify the patients’ spiritual needs and concerns prior to surgery both from the patients’ and surgical healthcare staffs’ perspectives and to investigate whether there was congruence between the groups. The results of the staff focus groups are presented here. A purposive; convenience sample of 13 staff (nurses; consultants and pharmacists) attended one of three focus groups. Data were analysed utilising interpretive phenomenological analysis in order to discover the meaning for participants derived from their own contexts. Caring for spiritual and existential concerns was expressed through staff’s relationships with patients; by a caring attitude and connection with them; helping patients to cope. Results show that spiritual care can be embedded in day surgery practice; and can be given during fleeting care episodes; though awareness is needed of the way in which this can be achieved.
Citizen Science and Crowdsourcing for Earth Observations: An Analysis of Stakeholder Opinions on the Present and Future
Authors: Mazumdar Suvodeep , Wrigley Stuart , Ciravegna Fabio
Published: January 2017

The impact of Crowdsourcing and citizen science activities on academia, businesses, governance and society has been enormous. This is more prevalent today with citizens and communities collaborating with organizations, businesses and authorities to contribute in a variety of manners, starting from mere data providers to being key stakeholders in various decision-making processes. The “Crowdsourcing for observations from Satellites” project is a recently concluded study supported by demonstration projects funded by European Space Agency (ESA). The objective of the project was to investigate the different facets of how crowdsourcing and citizen science impact upon the validation, use and enhancement of Observations from Satellites (OS) products and services. This paper presents our findings in a stakeholder analysis activity involving participants who are experts in crowdsourcing, citizen science for Earth Observations. The activity identified three critical areas that needs attention by the community as well as provides suggestions to potentially help in addressing some of the challenges identified.
High Resolution Aerosol Optical Depth Retrieval Using Gaofen-1 WFV Camera Data
Authors: Sun Kun , Chen Xiaoling , Zhu Zhongmin , Zhang Tianhao
Published: January 2017

Aerosol Optical Depth (AOD) is crucial for urban air quality assessment. However, the frequently used moderate-resolution imaging spectroradiometer (MODIS) AOD product at 10 km resolution is too coarse to be applied in a regional-scale study. Gaofen-1 (GF-1) wide-field-of-view (WFV) camera data, with high spatial and temporal resolution, has great potential in estimation of AOD. Due to the lack of shortwave infrared (SWIR) band and complex surface reflectivity brought from high spatial resolution, it is difficult to retrieve AOD from GF-1 WFV data with traditional methods. In this paper, we propose an improved AOD retrieval algorithm for GF-1 WFV data. The retrieved AOD has a spatial resolution of 160 m and covers all land surface types. Significant improvements in the algorithm include: (1) adopting an improved clear sky composite method by using the MODIS AOD product to identify the clearest days and correct the background atmospheric effect; and (2) obtaining local aerosol models from long-term CIMEL sun-photometer measurements. Validation against MODIS AOD and ground measurements showed that the GF-1 WFV AOD has a good relationship with MODIS AOD (R2 = 0.66; RMSE = 0.27) and ground measurements (R2 = 0.80; RMSE = 0.25). Nevertheless, the proposed algorithm was found to overestimate AOD in some cases, which will need to be improved upon in future research.
Modeling Aboveground Biomass in Hulunber Grassland Ecosystem by Using Unmanned Aerial Vehicle Discrete Lidar
Authors: Wang Dongliang , Xin Xiaoping , Shao Quanqin , Brolly Matthew , Zhu Zhiliang , Chen Jin
Published: January 2017

Accurate canopy structure datasets, including canopy height and fractional cover, are required to monitor aboveground biomass as well as to provide validation data for satellite remote sensing products. In this study, the ability of an unmanned aerial vehicle (UAV) discrete light detection and ranging (lidar) was investigated for modeling both the canopy height and fractional cover in Hulunber grassland ecosystem. The extracted mean canopy height, maximum canopy height, and fractional cover were used to estimate the aboveground biomass. The influences of flight height on lidar estimates were also analyzed. The main findings are: (1) the lidar-derived mean canopy height is the most reasonable predictor of aboveground biomass (R2 = 0.340, root-mean-square error (RMSE) = 81.89 g·m−2, and relative error of 14.1%). The improvement of multiple regressions to the R2 and RMSE values is unobvious when adding fractional cover in the regression since the correlation between mean canopy height and fractional cover is high; (2) Flight height has a pronounced effect on the derived fractional cover and details of the lidar data, but the effect is insignificant on the derived canopy height when the flight height is within the range (<100 m). These findings are helpful for modeling stable regressions to estimate grassland biomass using lidar returns.
Current and Emerging Technology for Continuous Glucose Monitoring
Authors: Chen Cheng , Zhao Xue-Ling , Li Zhan-Hong , Zhu Zhi-Gang , Qian Shao-Hong , Flewitt Andrew
Published: January 2017

Diabetes has become a leading cause of death worldwide. Although there is no cure for diabetes, blood glucose monitoring combined with appropriate medication can enhance treatment efficiency, alleviate the symptoms, as well as diminish the complications. For point-of-care purposes, continuous glucose monitoring (CGM) devices are considered to be the best candidates for diabetes therapy. This review focuses on current growth areas of CGM technologies, specifically focusing on subcutaneous implantable electrochemical glucose sensors. The superiority of CGM systems is introduced firstly, and then the strategies for fabrication of minimally-invasive and non-invasive CGM biosensors are discussed, respectively. Finally, we briefly outline the current status and future perspective for CGM systems.
A Distributed and Energy-Efficient Algorithm for Event K-Coverage in Underwater Sensor Networks
Authors: Jiang Peng , Xu Yiming , Liu Jun
Published: January 2017

For event dynamic K-coverage algorithms, each management node selects its assistant node by using a greedy algorithm without considering the residual energy and situations in which a node is selected by several events. This approach affects network energy consumption and balance. Therefore, this study proposes a distributed and energy-efficient event K-coverage algorithm (DEEKA). After the network achieves 1-coverage, the nodes that detect the same event compete for the event management node with the number of candidate nodes and the average residual energy, as well as the distance to the event. Second, each management node estimates the probability of its neighbor nodes’ being selected by the event it manages with the distance level, the residual energy level, and the number of dynamic coverage event of these nodes. Third, each management node establishes an optimization model that uses expectation energy consumption and the residual energy variance of its neighbor nodes and detects the performance of the events it manages as targets. Finally, each management node uses a constrained non-dominated sorting genetic algorithm (NSGA-II) to obtain the Pareto set of the model and the best strategy via technique for order preference by similarity to an ideal solution (TOPSIS). The algorithm first considers the effect of harsh underwater environments on information collection and transmission. It also considers the residual energy of a node and a situation in which the node is selected by several other events. Simulation results show that, unlike the on-demand variable sensing K-coverage algorithm, DEEKA balances and reduces network energy consumption, thereby prolonging the network’s best service quality and lifetime.
Underwater Electromagnetic Sensor Networks—Part I: Link Characterization
Authors: Quintana-Díaz Gara , Mena-Rodríguez Pablo , Pérez-Álvarez Iván , Jiménez Eugenio , Dorta-Naranjo Blas-Pablo , Zazo Santiago , Pérez Marina , Quevedo Eduardo , Cardona Laura , Hernández J.
Published: January 2017

Underwater Wireless Sensor Networks (UWSNs) using electromagnetic (EM) technology in marine shallow waters are examined, not just for environmental monitoring but for further interesting applications. Particularly, the use of EM waves is reconsidered in shallow waters due to the benefits offered in this context, where acoustic and optical technologies have serious disadvantages. Sea water scenario is a harsh environment for radiocommunications, and there is no standard model for the underwater EM channel. The high conductivity of sea water, the effect of seabed and the surface make the behaviour of the channel hard to predict. This justifies the need of link characterization as the first step to approach the development of EM underwater sensor networks. To obtain a reliable link model, measurements and simulations are required. The measuring setup for this purpose is explained and described, as well as the procedures used. Several antennas have been designed and tested in low frequency bands. Agreement between attenuation measurements and simulations at different distances was analysed and made possible the validation of simulation setups and the design of different communications layers of the system. This leads to the second step of this work, where data and routing protocols for the sensor network are examined.
Sex Differences in Countermovement Jump Phase Characteristics
Authors: McMahon John , Rej Sophie , Comfort Paul
Published: January 2017

The countermovement jump (CMJ) is commonly used to explore sex differences in neuromuscular function, but previous studies have only reported gross CMJ measures or have partly examined CMJ phase characteristics. The purpose of this study was to explore differences in CMJ phase characteristics between male and female athletes by comparing the force-, power-, velocity-, and displacement-time curves throughout the entire CMJ, in addition to gross measures. Fourteen men and fourteen women performed three CMJs on a force platform from which a range of kinetic and kinematic variables were calculated via forward dynamics. Jump height (JH), reactive strength index modified, relative peak concentric power, and eccentric and concentric displacement, velocity, and relative impulse were all greater for men (g = 0.58–1.79). Relative force-time curves were similar between sexes, but relative power-, velocity-, and displacement-time curves were greater for men at 90%–95% (immediately before and after peak power), 47%–54% (start of eccentric phase) and 85%–100% (latter half of concentric phase), and 65%–87% (bottom of countermovement and initial concentric phase) of normalized jump time, respectively. The CMJ distinguished between sexes, with men demonstrating greater JH through applying a larger concentric impulse and, thus, achieving greater velocity throughout most of the concentric phase, including take-off.
A Linkage Model of Supply Chain Operation and Financial Performance for Economic Sustainability of Firm
Authors: Jin Suk , Jeong Suk , Kim Kyung
Published: January 2017

Although several studies have explored the relationship between the operation and performance of a supply chain (SC), a general SC model cannot deliver the expected financial results at a company-wide level. In this paper, we argue that this cannot guarantee the maximization of a firm’s overall value because short-term financial performance metrics do not reflect the risk to businesses and the invested capital. Owing to the varying natures of risk and the capital invested, firms with multiple divisions should assess each division separately, and the results can be compared for decisions concerning the allocation of the firm’s capital and resources to maximize the overall value of its businesses. We propose a linkage model to consider operational activities and financial performance simultaneously in a firm’s supply chain model. To exhibit the superiority of the proposed model that connects SC operation and financial indicators, we first compare the differences between models for maximizing profit and enterprise-wise economic value added (EVA) as objective functions. To examine uncertainty in the operational and financial parameters of the SC, the results of sensitivity analyses are then reported. Experimental results showed that our model, using the EVA approach, is more effective and superior in terms of maximizing the firm’s overall value from the long-term perspective while satisfying the target values for financial ratios set by the firm’s executives and shareholders for all periods, unlike the results of the general model.
Consumers’ Perspective on Circular Economy Strategy for Reducing Food Waste
Authors: Borrello Massimiliano , Caracciolo Francesco , Lombardi Alessia , Pascucci Stefano , Cembalo Luigi
Published: January 2017

The current linear system of production and consumption is unsustainable. In the food sector, despite the fact that valuable natural resources are intensively used to produce and distribute food products, little is done to upcycle residues generated along the supply chain. Circular economy strategies are crucial for restructuring the take-make-dispose model through the active participation of all actors of supply chains. However, little is known about consumers’ willingness to participate in circular economy. A structured questionnaire was submitted to a representative sample of Italian households to assess the willingness of consumers to be actively involved in closed loops aiming at reducing food waste. Consumers are involved by returning their organic food waste to retailers in exchange for discounts on the purchase of animal products. The organic food waste returned enters in the production process of animal products. A choice experiment was designed to analyse alternative programs. Two scenarios were presented: one with a traditional technology (composting), and a second one with a radically innovative technology (insects as feed). Preferences and trade-offs, in monetary terms, among attributes were computed. Results depict a comprehensive portrait of the potential participation of consumers to closed loops inspired by the principles of circular economy.
A New Resilience Measure for Supply Chain Networks
Authors: Li Ruiying , Dong Qiang , Jin Chong , Kang Rui
Published: January 2017

Currently, supply chain networks can span the whole world, and any disruption of these networks may cause economic losses, decreases in sales and unsustainable supplies. Resilience, the ability of the system to withstand disruption and return to a normal state quickly, has become a new challenge during the supply chain network design. This paper defines a new resilience measure as the ratio of the integral of the normalized system performance within its maximum allowable recovery time after the disruption to the integral of the performance in the normal state. Using the maximum allowable recovery time of the system as the time interval under consideration, this measure allows the resilience of different systems to be compared on the same relative scale, and be used under both scenarios that the system can or cannot restore in the given time. Two specific resilience measures, the resilience based on the amount of product delivered and the resilience based on the average delivery distance, are provided for supply chain networks. To estimate the resilience of a given supply chain network, a resilience simulation method is proposed based on the Monte Carlo method. A four-layered hierarchial mobile phone supply chain network is used to illustrate the resilience quantification process and show how network structure affects the resilience of supply chain networks.
Development and Application of a Low Impact Development (LID)-Based District Unit Planning Model
Authors: Son Cheol , Hyun Kyoung , Kim Donghyun , Baek Jong , Ban Yong
Published: January 2017

The purpose of this study was to develop a low impact development-based district unit planning (LID-DP) model and to verify the model by applying it to a test site. To develop the model, we identified various barriers to the urban planning process and examined the advantages of various LID-related techniques to determine where in the urban development process LID would provide the greatest benefit. The resulting model provides (1) a set of district unit planning processes that consider LID standards and (2) a set of evaluation methods that measure the benefits of the LID-DP model over standard urban development practices. The developed LID-DP process is composed of status analysis, comprehensive analysis, basic plan, and sectoral plans. To determine whether the LID-DP model met the proposed LID targets, we applied the model to a test site in Cheongju City, Chungcheongbuk-do Province, Republic of Korea. The test simulation showed that the LID-DP plan reduced nonpoint source pollutants (total nitrogen, 113%; total phosphorous, 193%; and biological oxygen demand, 199%); reduced rainfall runoff (infiltration volume, 102%; surface runoff, 101%); and improved the conservation rate of the natural environment area (132%). The successful application of this model also lent support for the greater importance of non-structural techniques over structural techniques in urban planning when taking ecological factors into account.
Perspective on Global Measles Epidemiology and Control and the Role of Novel Vaccination Strategies
Authors: Coughlin Melissa , Beck Andrew , Bankamp Bettina , Rota Paul
Published: January 2017

Measles is a highly contagious, vaccine preventable disease. Measles results in a systemic illness which causes profound immunosuppression often leading to severe complications. In 2010, the World Health Assembly declared that measles can and should be eradicated. Measles has been eliminated in the Region of the Americas, and the remaining five regions of the World Health Organization (WHO) have adopted measles elimination goals. Significant progress has been made through increased global coverage of first and second doses of measles-containing vaccine, leading to a decrease in global incidence of measles, and through improved case based surveillance supported by the WHO Global Measles and Rubella Laboratory Network. Improved vaccine delivery methods will likely play an important role in achieving measles elimination goals as these delivery methods circumvent many of the logistic issues associated with subcutaneous injection. This review highlights the status of global measles epidemiology, novel measles vaccination strategies, and describes the pathway toward measles elimination.
The IMPORTance of the Nucleus during Flavivirus Replication
Authors: Lopez-Denman Adam , Mackenzie Jason
Published: January 2017

Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever. It is well understood that flaviviruses modulate the composition and structure of membranes in the cytoplasm that are crucial for efficient replication and evading immune detection. As the flavivirus genome consists of positive sense RNA, replication can occur wholly within the cytoplasm. What is becoming more evident is that some viral proteins also have the ability to translocate to the nucleus, with potential roles in replication and immune system perturbation. In this review, we discuss the current understanding of flavivirus nuclear localisation, and the function it has during flavivirus infection. We also describe—while closely related—the functional differences between similar viral proteins in their nuclear translocation.
The Astrovirus Capsid: A Review
Authors: Arias Carlos , DuBois Rebecca
Published: January 2017

Astroviruses are enterically transmitted viruses that cause infections in mammalian and avian species. Astroviruses are nonenveloped, icosahedral viruses comprised of a capsid protein shell and a positive-sense, single-stranded RNA genome. The capsid protein undergoes dramatic proteolytic processing both inside and outside of the host cell, resulting in a coordinated maturation process that affects cellular localization, virus structure, and infectivity. After maturation, the capsid protein controls the initial phases of virus infection, including virus attachment, endocytosis, and genome release into the host cell. The astrovirus capsid is the target of host antibodies including virus-neutralizing antibodies. The capsid protein also mediates the binding of host complement proteins and inhibits complement activation. Here, we will review our knowledge on the astrovirus capsid protein (CP), with particular attention to the recent structural, biochemical, and virological studies that have advanced our understanding of the astrovirus life cycle.
Hydrogeochemistry and Genesis Analysis of Thermal and Mineral Springs in Arxan, Northeastern China
Authors: Gu Xiaomin , Zhang Qiulan , Cui Yali , Shao Jingli , Xiao Yong , Zhang Peng , Liu Jinxing
Published: January 2017

In this work, the hydrogeochemistry and environmental isotopic compositions of thermal and mineral springs in Arxan, northeastern China, were used to assess the genesis of the thermal system hosted by deep-seated faults. The reservoir temperature was calculated using the mineral saturation index and geothermometers. According to isotopic analysis, the spring water was of meteoric origin. Sixteen springs in the Arxan geothermal system with outlet temperatures ranging from 10.9 to 41.0 °C were investigated. The water samples can be classified into four groups by using a Piper diagram. The aquifer in which the Group I and Group III samples were obtained was a shallow cold aquifer of the Jurassic system, which is related to the local groundwater system and contains HCO3–Ca·Na groundwater. The Group II and Group IV samples were recharged by deeply circulating meteoric water with HCO3–Na and HCO3·SO4–Na·Ca groundwater, respectively. The springs rise from the deep basement faults. The estimated thermal reservoir temperature is 50.9–68.8 °C, and the proportion of shallow cold water ranges from 54% to 87%. A conceptual flow model based on hydrogeochemical results and hydrogeological features is given to describe the geothermal system of the Arxan springs.
Species conservation profile of the stenoendemic cave spider Pimoa delphinica (Araneae, Pimoidae) from the Varaita valley (NW-Italy)
Authors: Mammola Stefano , Hormiga Gustavo , Isaia Marco
Published: January 2017

Pimoa delphinica Mammola, Hormiga & Isaia, 2016 is a troglophile araneoid spider endemic of the high Varaita valley (Western Alps, Province of Cuneo, NW Italy). In spite of relatively intense field research and examination of museum collections, the species is restricted to ten localities, thus showing a reduced extent of occurrence (EOO; 26 km2) and area of occupancy (AOO; 12 km2). Although the habitat and the subpopulations of P. delphinica are not currently threatened, the species is potentially exposed due to its extremely narrow geographic distribution range, subdivision in subpopulations and low dispersal capacity.
Disease Characteristics and Rheumatoid Arthritis Development in Patients with Early Undifferentiated Arthritis: A 2-year Followup Study
Authors: Brinkmann Gina H. , Norli Ellen S. , Kvien Tore K. , Haugen Anne J. , Grøvle Lars , Nygaard Halvor , Bjørneboe Olav , Thunem Cathrine , Mjaavatten Maria D. , Lie Elisabeth
Published: January 2017

Objective.

To examine the 2-year disease course in patients with undifferentiated arthritis (UA) focusing on fulfillment of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) classification criteria.

Methods.

Data were provided by the Norwegian Very Early Arthritis Clinic study, which included patients presenting with ≥ 1 swollen joint of ≤ 16 weeks’ duration. UA was defined as patients not fulfilling the 2010 ACR/EULAR RA criteria and who did not have a clinical diagnosis other than RA at baseline. The main outcome was fulfillment of the 2010 RA criteria. Secondary outcomes were disease-modifying antirheumatic drug (DMARD) use, resolution of synovitis without use of DMARD during followup, and final clinical diagnosis.

Results.

We included 477 patients with UA of whom 47 fulfilled the 2010 ACR/EULAR RA criteria during followup (UA-RA) and 430 did not (UA–non-RA). Of the UA-RA patients, 70% fulfilled the criteria within the first 6 months. UA-RA patients were older, more often positive for rheumatoid factor and anticitrullinated protein antibodies, female, and ever smokers, and they more often presented with polyarticular arthritis, small joint involvement, and a swollen shoulder joint. During followup, 53% of UA-RA patients vs 13% of UA-non-RA patients used DMARD (p < 0.001). Overall, 71% of patients with UA achieved absence of clinical synovitis at final followup without use of DMARD. The most frequent final clinical diagnosis was UA (61%).

Conclusion.

Only 9.8% of patients with UA fulfilled the 2010 RA criteria during 2-year followup. Small joint involvement and swollen shoulder joint were among the factors associated with RA development. In two-thirds of patients with UA, the arthritis resolved without use of DMARD.
Credit concession through credit scoring: Analysis and application proposal
Authors: Amat Oriol , Manini Raffaele , Antón Renart Marcos
Published: January 2017

Purpose: The study herein develops and tests a credit scoring model which can help financial institutions in assessing credit requests. Design/methodology/approach: The empirical study has the objective of answering two questions: (1) Which ratios better discriminate the companies based on their being solvent or insolvent? and (2) What is the relative importance of these ratios? To do this, several statistical techniques with a multifactorial focus have been used (Multivariate Analysis of Variance, Linear Discriminant Analysis, Logit and Probit Models). Several samples of companies have been used in order to obtain and to test the model. Findings: Through the application of several statistical techniques, the credit scoring model has been proved to be effective in discriminating between good and bad creditors. Research limitations:  This study focuses on manufacturing, commercial and services companies of all sizes in Spain; Therefore, the conclusions may differ for other geographical locations.Practical implications:  Because credit is one of the main drivers of growth, a solid credit scoring model can help financial institutions assessing to whom to grant credit and to whom not to grant credit.Social implications: Because of the growing importance of credit for our society and the fear of granting it due to the latest financial turmoil, a solid credit scoring model can strengthen the trust toward the financial institutions assessment’s. Originality/value: There is already a stream of literature related to credit scoring. However, this paper focuses on Spanish firms and proves the results of our model based on real data. The application of the model to detect the probability of default in loans is original.
Metrically conditioned pitch and layered feet in Chugach Alutiiq
Authors: Martínez-Paricio Violeta , Kager René
Published: January 2017

This article presents a reanalysis of the foot-based phonology of Chugach Alutiiq (henceforth CA), a language that displays a complex mixed ternary–binary rhythm, as well as metrically conditioned distributions of pitch, fortition and vowel lengthening. Elaborating on earlier analyses of CA that had posited some kind of ternary constituent (Hewitt, 1991, 1992; Leer, 1985a, 1985b, 1985c; Rice, 1992), we propose CA should be analyzed by means of the Internally Layered Ternary (ILT) foot, a minimal recursive foot (Prince, 1980; Selkirk, 1980), which was recently revived in a typological study of binary–ternary stress (Martínez-Paricio & Kager, 2015). It will be argued that ILT feet capture CA’s puzzling dual behavior of unstressed and stressed syllables straightforwardly by referring to the status of syllables as heads or dependents of minimal or non-minimal feet. After showing the value of ILT feet in the analysis of CA rhythmic and segmental patterns, we turn to our analytical focus, the distributions of high and low pitch. This distribution is arguably metrically conditioned, yet an analysis based on stress or standard binary feet cannot capture it, whereas the ILT approach can. To highlight the advantages of our approach, we end by offering brief comparisons with previous analyses of CA.
A ALIENAÇÃO PARENTAL NO BRASIL: UMA REVISÃO DAS PUBLICAÇÕES CIENTÍFICAS
Authors: Soma Sheila Maria Prado , Castro Marina Souto Bezerra Lopes de , Williams Lúcia Cavalcanti de Albuquerque , Tannús Pedro Magrin
Published: January 2017

De grande relevância às áreas comuns da psicologia e direito, o tema da Alienação Parental (AP), bem como da Síndrome de Alienação Parental (SAP), ganhou destaque nacional a partir da aprovação da lei 12.318/2010, que prevê punição para a prática alienadora e determina a atuação do psicólogo judiciário na investigação dos casos suspeitos. Contudo trata-se de assunto controverso do ponto de vista científico, sendo que, em nosso país, há grande carência por estudos. Com o objetivo de traçar um panorama nacional sobre as pesquisas na área, o presente estudo consistiu na revisão da literatura científica brasileira sobre o assunto até julho de 2015. Foram selecionados e analisados 13 artigos, sendo que nove deles são textos dissertativos e apenas quatro apresentam resultados de investigações empíricas. Infelizmente a maioria dos artigos encontrados, inclusive os estudos empíricos, não parece trazer contribuições relevantes para a área. Conclui-se que a baixa produção de estudos científicos sobre o tema prejudica o desenvolvimento conceitual e a atuação dos profissionais que trabalham com famílias em disputas judiciais.
Modulation of Naive CD8 T Cell Response Features by Ligand Density, Affinity, and Continued Signaling via Internalized TCRs
Authors: Balyan Renu , Gund Rupali , Ebenezer Chitra , Khalsa Jasneet Kaur , Verghese Divya Anna , Krishnamurthy Thyagarajan , George Anna , Bal Vineeta , Rath Satyajit , Chaudhry Ashutosh
Published: January 2017

T cell response magnitudes increase with increasing antigenic dosage. However, it is unclear whether ligand density only modulates the proportions of responding ligand-specific T cells or also alters responses at the single cell level. Using brief (3 h) exposure of TCR-transgenic mouse CD8 T cells in vitro to varying densities of cognate peptide-MHC ligand followed by ligand-free culture in IL-2, we found that ligand density determined the frequencies of responding cells but not the expression levels of the early activation marker molecule, CD69. Cells with low glucose uptake capacity and low protein synthesis rates were less ligand-sensitive, implicating metabolic competence in the response heterogeneity of CD8 T cell populations. Although most responding cells proliferated, ligand density was associated with time of entry into proliferation and with the extent of cell surface TCR downmodulation. TCR internalization was associated, regardless of the ligand density, with rapidity of c-myc induction, loss of the cell cycle inhibitor p27kip1, metabolic reprogramming, and cell cycle entry. A low affinity peptide ligand behaved, regardless of ligand density, like a low density, high affinity ligand in all these parameters. Inhibition of signaling after ligand exposure selectively delayed proliferation in cells with internalized TCRs. Finally, internalized TCRs continued to signal and genetic modification of TCR internalization and trafficking altered the duration of signaling in a T cell hybridoma. Together, our findings indicate that heterogeneity among responding CD8 T cell populations in their ability to respond to TCR-mediated stimulation and internalize TCRs mediates detection of ligand density or affinity, contributing to graded response magnitudes.
Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells
Authors: Goverse Gera , Molenaar Rosalie , Macia Laurence , Tan Jian , Erkelens Martje N. , Konijn Tanja , Knippenberg Marlene , Cook Emma C. L. , Hanekamp Diana , Veldhoen Marc , Hartog Anita , Roeselers Guus , Mackay Charles R. , Mebius Reina E.
Published: January 2017

The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the vitamin A–converting enzyme RALDH1 in intestinal epithelial cells in vivo and in vitro, respectively. Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A–converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. Moreover, we show that the consumption of dietary fiber can alter the composition of SCFA-producing microbiota and SCFA production in the small intestines. In conclusion, our data illustrate that dietary adjustments affect small intestinal epithelial cells and can be used to modulate the mucosal immune system.
Analysing challenges facing smallholder farmers and conservation agriculture in South Africa: A system dynamics approach
Authors: Von Loeper Wolfgang , Musango Josephine , Brent Alan , Drimie Scott
Published: January 2017

Smallholder farmers in South Africa find it challenging to participate in the modern economy. Most of these farmers have limited access to credit and insurance, and to markets in which to sell their produce. This paper reviews ethnographic research data and argues that smallholder farmers struggle to take part in modern agricultural value chains in South Africa. System dynamics modelling is used to understand the dynamics relating to agricultural value-chain participants, and to determine whether the ethnographic research data is sufficient to answer the question as to which value-chain participants potentially have the largest impact on smallholder farmers. The modelling results show that banks may have the potential to trigger an impact on smallholder farmers’ productivity that could then attract other value-chain industries to take part in efforts to support these farmers. Smallholder farmers could become a long-term viable and sustainable option for increasing food security in South Africa. However, this study has its limitations. The data used from existing ethnographic research, conducted by way of semi-structured interviews with valuechain participants, is limited and is not able to answer questions such as: (i) how much each industry is prepared to engage with smallholder farmers in the event of other industries being prepared to do the same; and (ii) how long it will take each industry to react to a willingness to engage. Ongoing research is required to extend the interviewee base and data in order to answer these questions and for the model to be completed and used for policy guidance.
De stage als precarisering van arbeid. Ervaringen van afgestudeerde stagiairs in Nederland
Authors: van Vulpen Bram , van den Berg Marguerite
Published: January 2017

Increasingly, the internship is not a stage in the educational process, but the first step young people set on the labour market. In this article, the internship is considered as an example of precarisation of labour. The lived experiences of internships by highly educated graduated interns are studied, using semi structured interviews. This data show how the internship is an important form of taking care of the self: a way to invest in the project the career is. This often even implies that labour is disconnected from being paid: money is seen by the interns as a perverse impetus for working. This ethopolitic makes the interns highly susceptible for exploitation.
Chemical oxidative potential of secondary organic aerosol (SOA) generated from the photooxidation of biogenic and anthropogenic volatile organic compounds
Authors: Tuet Wing Y. , Chen Yunle , Xu Lu , Fok Shierly , Gao Dong , Weber Rodney J. , Ng Nga L.
Published: January 2017

Abstract. Particulate matter (PM), of which a significant fraction is comprised of secondary organic aerosols (SOA), has received considerable attention due to its health implications. In this study, the water-soluble oxidative potential (OPWS) of SOA generated from the photooxidation of biogenic and anthropogenic hydrocarbon precursors (isoprene, α-pinene, β-caryophyllene, pentadecane, m-xylene, and naphthalene) under different reaction conditions (RO2+ HO2 vs. RO2+ NO dominant, dry vs. humid) was characterized using dithiothreitol (DTT) consumption. The measured intrinsic OPWS-DTT values ranged from 9 to 205 pmol min−1 µg−1 and were highly dependent on the specific hydrocarbon precursor, with naphthalene and isoprene SOA generating the highest and lowest OPWS-DTT values, respectively. Humidity and RO2 fate affected OPWS-DTT in a hydrocarbon-specific manner, with naphthalene SOA exhibiting the most pronounced effects, likely due to the formation of nitroaromatics. Together, these results suggest that precursor identity may be more influential than reaction condition in determining SOA oxidative potential, demonstrating the importance of sources, such as incomplete combustion, to aerosol toxicity. In the context of other PM sources, all SOA systems, with the exception of naphthalene SOA, were less DTT active than ambient sources related to incomplete combustion, including diesel and gasoline combustion as well as biomass burning. Finally, naphthalene SOA was as DTT active as biomass burning aerosol, which was found to be the most DTT-active OA source in a previous ambient study. These results highlight a need to consider SOA contributions (particularly from anthropogenic hydrocarbons) to health effects in the context of hydrocarbon emissions, SOA yields, and other PM sources.
A comparison of Loon balloon observations and stratospheric reanalysis products
Authors: Friedrich Leon S. , McDonald Adrian J. , Bodeker Gregory E. , Cooper Kathy E. , Lewis Jared , Paterson Alexander J.
Published: January 2017

Abstract. Location information from long-duration super-pressure balloons flying in the Southern Hemisphere lower stratosphere during 2014 as part of X Project Loon are used to assess the quality of a number of different reanalyses including National Centers for Environmental Prediction Climate Forecast System version 2 (NCEP-CFSv2), European Centre for Medium-Range Weather Forecasts (ERA-Interim), NASA Modern Era Retrospective-Analysis for Research and Applications (MERRA), and the recently released MERRA version 2. Balloon GPS location information is used to derive wind speeds which are then compared with values from the reanalyses interpolated to the balloon times and locations. All reanalysis data sets accurately describe the winds, with biases in zonal winds of less than 0.37 m s−1 and meridional biases of less than 0.08 m s−1. The standard deviation on the differences between Loon and reanalyses zonal winds is latitude-dependent, ranging between 2.5 and 3.5 m s−1, increasing equatorward. Comparisons between Loon trajectories and those calculated by applying a trajectory model to reanalysis wind fields show that MERRA-2 wind fields result in the most accurate simulated trajectories with a mean 5-day balloon–reanalysis trajectory separation of 621 km and median separation of 324 km showing significant improvements over MERRA version 1 and slightly outperforming ERA-Interim. The latitudinal structure of the trajectory statistics for all reanalyses displays marginally lower mean separations between 15 and 35° S than between 35 and 55° S, despite standard deviations in the wind differences increasing toward the equator. This is shown to be related to the distance travelled by the balloon playing a role in the separation statistics.