bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Body Mass Index on postoperative pain and opioïd administration after pressurized intraperitoneal aerosol chemotherapy (PIPAC) in the treatment of peritoneal carcinomatosis.
Authors: Tidadini Fatah , Trilling Bertrand , Quesada Jean-Louis , Abba Julio , Foote Alison , Faucheron Jean-Luc , Arvieux Catherine
Published: April 2023

BACKGROUND Intraperitoneal aerosol spray chemotherapy (PIPAC) is a new surgical technique, developed for the treatment of peritoneal carcinomatosis (PC). In this retrospective observational study we assessed the impact of body mass index (BMI) on postoperative pain and opioid consumption.METHODS We analysed pain scores after 100 PIPAC procedures with either oxaliplatin or doxorubicin-cisplatin performed in 49 patients with PC between July 2016 and September 2020. The patients were divided into 4 groups (BMI < 18.5, 18.5 ≥ BMI < 25, 25 ≥ BMI ≤ 29.9 and BMI ≥ 30). Pain was self-rated on a visual analogue scale (VAS) from 0 to 10.RESULTS Univariate logistic regression analysis identified oxaliplatin to be associated with moderate to severe pain (VAS 4–10 at 8h D1) before (OR [95% CI]; 3.75[1.33–10.54]; p = 0.012) and after adjustment (OR [95% CI]; 4.13[1.41–12.11] p = 0.010) on BMI. The level of pain appeared significantly different between the treatment groups (median 2.5[0; 5] vs 0[0; 2.5] p = 0.0017) irrespective of BMI (p = 0.46 and p = 0.226). Multivariate logistic regression analysis identified moderate to severe pain and synchronous PC to be associated with greater use of opioids (OR [95% CI]: 3.91 [1.24–12.32]) and (OR [95% CI]: 5.16 [1.71–15.58]; respectively. Opioids were administered after 45 procedures (45%) and was comparable between the treatment groups. Opioid administration and length-of-stay were similar among BMI bands.CONCLUSION We conclude that BMI is not related to postoperative pain or opioid use and that moderate to severe pain and synchronous PC are factors associated with requiring opioïds.
Fuzzy Logic Control of an Automatic Changeover for the Management of a Grid-Connected Photovoltaic System
Authors: Dandoussou Abraham , Kenfack Pierre
Published: April 2023

The main objective is to design a smart switch controlled using fuzzy logic which is able to take decisions on the different sources of energy in a very brief ‘switching time’ to avoid load shedding. For that, a fuzzy controller is implemented by considering input signals from three power sources: Photovoltaic array, batteries and grid. The inputs are: irradiance being the instantaneous measurement of solar energy, voltage range for the power grid and state of charge for the battery to be able to know if the battery can supply or not. For these corresponding inputs, Takagi’s fuzzy inference system was applied, that permitted to have linear constant as outputs. As such able to control the switch with respect to the source available at a particular period of the day, either day or night. Designing the fuzzy logic controller was able to take decisions with respect to the conditions. The load feeding signal behaviour has been obtained when either of the switches are open or closed over a period of 1000s. In this system the batteries charge is either done by the PV array or the power grid according to the established rules of the system.
Two cases of gastrointestinal tumor with uterine cervical metastases: a case report
Authors: Xie Jiayuan , Wu Wenhui , Zhang Hua , Yang Huan , Guo Xue , Zhao Tingting , Zhang Changlin , Li Tian
Published: April 2023

Background: Gastrointestinal (GI) tumors are among the most prevalent malignant tumors worldwide. Recurrence and metastasis remain the leading causes of advanced GI tumor-related mortality. We present two rare cases of uterine cervical metastases from GI tumors and describe the clinical and pathological diagnosis, therapeutic options, and prognosis from a molecular biology perspective.
Case presentation: We present the case of a 55-year-old Asian woman treated for sigmoid adenocarcinoma. The patient underwent a sigmoid colon resection without chemotherapy. Six months later, the tumor in the patient’s pelvis recurred, and she underwent pelvic lesion resection and bilateral adnexectomy. The patient underwent frequent chemotherapy, radiotherapy, targeted therapy, and immunotherapy after surgery. Five years later, the patient was diagnosed with intestinal cancer and cervical metastasis due to vaginal bleeding. Another case involved a 54-year-old Asian woman with poorly differentiated adenocarcinoma of the stomach who underwent radical gastrectomy, left adnexal metastasis 1 year later, and bilateral adnexectomy. After surgery, insufficient chemotherapy was administered, and a year later, vaginal bleeding revealed metastatic adenocarcinoma of the cervix.
Conclusions: Although cervical metastases from gastrointestinal tumors are rare, physicians should be aware of this risk. According to these guidelines, surgical resection is necessary for isolated cervical metastases, and systemic treatment is preferred if multiple metastases are present. However, in the present case, surgery was performed despite multiple metastases, which prolonged the patient's survival and improved the quality of life. Treatment options should be individualized. It has been suggested that such patients undergo genetic testing to facilitate targeted drug selection and improve treatment outcomes.
Demicompact Linear Relations
Authors: Ammar Aymen , Daoued Houcem , Jeribi Aref
Published: April 2023

In this paper, we give new results on demicompact linear relations, we study some properties and some results on Fredholm and upper semi-Fredholm relations involving demicompact relations. Our results are used to establish a ne description of the essential spectrum and essential pseudospectrum of a linear relation.
Subject Classications (2000) : 47A06
An intuitive guide to processing RNA-seq reads
Authors: Prodhan M Asaduzzaman
Published: April 2023

The RNA sequencing technique known as ‘RNA-seq’ captures the expressed genes by sequencing the RNA molecules. In other words, the RNA-seq analysis allows for identifying the genes that are expressed in a given condition. Then, the functional annotation of these identified genes provides with the biological insights on how an organism operates in that particular condition. This RNA-seq along with many other genomic approaches are being increasingly applied as the sequencing cost is becoming affordable. However, analysing these sequencing data and extracting reliable biological insights from them remain a challenge due to the technical complexity of the sequencing data analysis. Here, I present a bioinformatics workflow from RNA-seq raw data processing to generating a gene expression matrix required for differential gene expression analysis. To help understand the computation steps in an RNA-seq workflow, I first illustrate on how the samples are prepared for RNA-seq purpose. The modifications made to the transcriptome during sample preparation for sequencing need to be reversed to reconstruct the original transcriptome. Furthermore, I provide with an example script for each step in the RNA-seq workflow and explain the codes concisely. This intuitive guide will be a valuable resource for a wide range of audience especially the graduate students and molecular biologists aiming to carry out RNA-seq analysis on their own for the first time.
Goldene: Free-standing Single-atom-thick Sheets of Gold
Authors: Kashiwaya Shun , Shi Yuchen , Lu Jun , Sangiovanni Davide , Andersson Mike , Rosen Johanna , Hultman Lars
Published: April 2023

The quest to make monolayer gold has hitherto been limited to a few atomic layers stabilized on or inside another material. Examples are monolayers diffused into double hydroxides1, sheets framed in Au-Ag alloys under electron irradiation2, nano-ribbons suspended in graphene3, single-atom-thick quantum dots on hexagonal BN4, monolayers in between SiC wafers and monolayer graphene5, and fragments produced via thermal dewetting on substrates6. Here, we report the synthesis of free-standing single-atom-thick 2D gold (named goldene) by wet-chemically etching away Ti3C2 from Ti3AuC2, a nano-laminated MAX-phase ceramic initially formed by substitution of Si in Ti3SiC2 with Au7. The free-standing goldene layers are revealed by scanning transmission electron microscopy. While ab initio molecular dynamics simulations show that 2D goldene is inherently stable, the experiments reveal a tendency for curling and agglomeration at edges. Prospects for preparing goldene from a series of non-van der Waals Au-intercalated MAX-phases, including developing etching schemes, are also presented.
Force of cutting by a single abrasive grain
Authors: Dimov Yu. V. , Podashev D. B.
Published: April 2023

This paper investigates the cutting forces arising when using a single abrasive grain. Analytical studies were carried out using a model of a single abrasive grain in the form of a rod with a radiused apex acting on the workpiece material. The slip-line method (method of characteristics) was used to calculate the deformation intensity of a plastically edged workpiece material under the action of a single grain. Mathematical models were developed for the following factors: plastic deformation of the material, edging of the stagnated zone and its friction against the grain surface when moved upwards in the form of chippings, grain friction against the plastically deformed material, and the action of the dynamic component of plastic deformation. The significance of the dynamic component in the overall balance of forces related to plastic deformation was established by determining the ratio of dynamic stress on the break line and shear yield point. This dependence calculated for D16T and 30HGSA materials showed the feasibility of accounting for the dynamic component of the cutting force under the velocity of a single grain impacting the workpiece surface of above 50 m/s. Graphs depicting the relative grain force and the relative depth of grain penetration are given. The proposed calculation method for cutting forces using a single grain can be used to determine the total force of interaction between the single grain and the work-piece material. In order to adopt the defined processing method and the workpiece material, the number of grains in contact, the contact duration, and the cutting speed should be found. On this basis, the process performance and the quality of the workpiece surface can be calculated.
Selecting optimal power consumption patterns in the Republic of Altai local grid system based on renewable and alternative power sources
Authors: Manusov V. Z. , Kalanakova A. V.
Published: April 2023

The authors develop a system of optimal planning of power consumption in the Republic of Altai local grid system based on a large proportion of renewable and alternative generating power sources. The studies were carried out using the linear programming method for power consumption patterns used by generating consumers. Power consumption charts by seasons and hourly retrospective rows of weather data by wind current velocity and solar insolation over 2021 were used as source data. Wind turbines, solar photovoltaic facilities, hydro-power plants, and energy accumulators were considered as local power consumption facilities to calculate electricity generation. The article provides calculation results for electricity generation in winter, since this is when a higher power deficiency is observed. It was shown that power consumers in the region under study can independently install additional generating power sources in the form of wind turbines, solar photovoltaic facilities, hydro-power plants, and energy accumulators due to electricity deficiency. Their combined generation mitigates the unpredictability of power generation by renewable sources. The authors propose a method that allows generating consumers to minimize their material and financial expenses and reduce the carbon footprint. The significance of the study consists in the substantiation of a hybrid power supply system with a high proportion of renewable and alternative power sources, which is implemented in the Republic of Altai and can be reproduced in other local energy systems with similar weather conditions.
Kinetics and mechanism of oxidizing roasting of sulfide copper-cobalt ore
Authors: Klyushnikov A. M. , Gulyaeva R. I. , Pikalov S. M. , Maltsev G. I.
Published: April 2023

The aim of the study was to examine the chemistry, kinetics and mechanism of oxidizing roasting of a typical sample of sulfide copper-cobalt ore. The research object was sulfide copper-cobalt ore with the following main minerals: pyrite, pyrrhotite, chalcopyrite, sphalerite, tremolite, silicon dioxide, talc, siderite and calcite. The methodology involved high-temperature X-ray phase analysis (100–900°C), thermogravimetry, differential scanning calorimetry and mass spectrometry of the released gas (30–1100°C, heating rate – 5–20°C·min-1, air flow rate – 30 cm3·min-1). The chemistry, kinetics and mechanism of oxidizing roasting of sulfide copper-cobalt ore with a particle size of <0.1 mm were studied. It was found that the process can be represented as a set of seven elementary reactions: five exothermic reactions (at 398–445, 394–488, 440–498, 433–549 and 451–562°C), corresponding to the intense combustion of iron, copper and zinc sulfides, and two endothermic reactions (at 651–664 and 743–927°C), associated with the decomposition of residual copper and iron sulfates. Kinetic analysis (Kissinger and Augis-Bennett methods, identification of the reaction model by reference function and iterative optimization) of differential scanning calorimetry data in connection with the above reactions showed that the limiting stage of the latter is nucleation and crystal growth. The values of activation energy, pre-exponential factor and Avrami parameter ranged between 140–459 kJ·mol-1, 1.41·104–3.49·1031 with-1 and 1.0–1.7, respectively. It was established that crystallization of the products of elementary reactions is accompanied by an increase in the number of nuclei; new phase nuclei can be formed both on the surface and in the bulk of ore particles. The crystal growth is one-dimensional and is controlled by a chemical reaction at the interphase boundary or by diffusion of reagents. The results obtained can be applied in the practice of oxidizing roasting of sulfide ores and concentrates.
Studies of stress and strain in bucket teeth of earth-moving machines
Authors: Osipov A. G. , Vasechkin U. A.
Published: April 2023

This paper aims to analyze the existing designs of bucket teeth in earth-moving machines with the purpose of selecting an optimal design in a scientifically grounded manner. The research objects included six design models of teeth of earth-moving machines made of alloyed manganese steel 110G13L. Teeth models were built using the KOMPAS-3D software. Lateral elastic internal stresses and elastic strains in the teeth models were determined using the COMSOL Multiphysics software. Lateral elastic internal stresses and elastic strains were calculated for the applied load of 9 kN in soft soil and 90 kN in rocky soil. Optimal teeth designs were determined for soils of various hardness. In soft soils, a ripper tooth and a combined curved tooth with an extra ripper tooth showed the optimum combination of efficiency and strength. Thus, provided that the elastic strain of a standard tooth in soft soils equals 100% and depending on the initial state, a ripper tooth and a combined curved tooth with an extra ripper tooth showed the strain values of 30–50% and 32–35%, respectively. In hard soils, a combined curved tooth with an extra ripper tooth and a regular curved tooth showed the optimum combination of efficiency and strength. Thus, provided that the elastic strain of a standard tooth in hard soil equals 100% and depending on the initial state, a combined curved tooth with an extra ripper tooth and a curved tooth showed the strain values of 18–20% and 42–45%, respectively. The feasibility of using buckets with combined teeth of optimal design in earth-moving machines was scientifically substantiated. Future research will investigate various bucket designs of earth-moving machines to find their optimal modifications for soils of various hardness.
Reduced power generation efficiency of solar panels in dusty locations
Authors: Kirpichnikova I. M. , Makhsumov I. B. , Shestakova V. V.
Published: April 2023

In this paper, we aim to investigate the performance of solar panels depending on the climate conditions of their location and the chemical and electrophysical characteristics of deposited dust. In particular, we study the effect of surface contamination of solar panels on their efficiency and determine the period of dust deposition that is critical in terms of power generation reduction. Experiments were conducted in April 2022 in the Republic of Tajikistan and the Chelyabinsk region of the Russian Federation. Both domestic and foreign publications on the impact of surface contamination on solar cell efficiency were reviewed. Comparative field experiments were carried out to investigate the performance of solar panels depending on environmental variables. It was found that the level of dust deposition in the Chelyabinsk region reached about 12–19 mg/m3, which is significantly lower than that in Tajikistan. However, due to its fine disperse structure, this dust is harder to remove. In Tajikistan, the capacity of the solar panel covered with dust de-creased by 46.64% relative to its nominal value in the first decade of April (the onset of dust storms). In the large industrial city of Chelyabinsk, the power output of the panels under study decreased by an average of 7.1% during this period. These findings confirm the importance of solar panel protection for maintaining the nominal values of solar power generation in the given regions. When no special protection devices are used, cleaning frequency for maintaining the re-quired efficiency of solar panels should be, on average, not less than once a week for both regions. A device is proposed for preventing dusting of the solar panel surface based on electron-ion technology. In addition, holographic films can be used to protect solar panels not only from dust contamination, but also from IR radiation. These protection approaches are the subject of future research.
Modern non-thermal method of processing plant raw materials used to increase its storability
Authors: Posokina N. E. , Zakharova A. I.
Published: April 2023

Along with thermal methods of processing plant raw materials, non-thermal processing methods have been actively developed in recent decades, which make it possible to preserve the qualitative characteristics of the initial raw materials to the maximum and increase the shelf life of the finished product. When using these methods, slight heating of the product can occur, for example, as in the processing by ultraviolet radiation (UVR). In the case of using such a type of processing as filtration, heating is completely absent; under the conditions of high pressure processing of the product (hereinafter HPP), a low temperature regime is observed. These methods are distinguished by minimizing the impact on the organoleptic characteristics of the finished product (texture, appearance, color, odor), as well as the preservation of micro- and macronutrients. The article discusses the main non-thermal methods of processing plant materials: high pressure (HPP), processing in a pulsed electric field (PEF), radioactive radiation, ultraviolet radiation (UVR), filtration. The advantages and factors hindering their widespread use on an industrial scale are noted. It is noted that high pressure, ultraviolet radiation and filtration to one degree or another are widely used in food production, while processing in a pulsed electric field and radioactive radiation are of extremely limited use due to the need to ensure the safety of processing for service  personnel. It should also be noted that processing only by non-thermal methods leads to a limited shelf life of finished products and often requires lower storage temperatures. If it is necessary to increase the shelf life, it makes sense to combine thermal and non-thermal processing methods, for example, microfiltration (ultrafiltration) of juice, bottling into consumer packaging, gentle pasteurization. The undoubted advantage of this combination can be a reduction in the thermal load on a product, since the initial microbiological contamination is reduced by filtration. And, as a result, we get a stably stored product with minimal quality loss and preserved native potential.
Unraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosa
Authors: Barros Elcio Daniel , Monção Filho Evaldo , Fonseca Mariluce , Alves Patrícia , Santos Antônia Laíres , Feitosa Chistiane , Silva Dulce Helena , Costa Pedro Mikael , Pessoa Cláudia , Campos Carmem , Monteiro Cristina , Chaves Mariana Helena , Vieira Júnior Gerardo
Published: April 2023

Toads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piauí state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 µg mL-1) and prostate (IC50 = 1.6 µg mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 µg mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.
Configuration design and load capacity analysis of pelvic fracture reduction robot
Authors: Cai Shenyang , Lei Jingtao , Rao Jinjun
Published: April 2023

Robot-assisted reduction of pelvic fracture requires large workspace and large load capacity. A kind of six degree-of-freedom (DOF) robot for pelvic fracture reduction is designed, which is a hybrid configuration composed of three-revolute-revolute-revolute (3RRR) parallel mechanism and three-dimensional guide rail. The hybrid configuration can ensure that the robot meet the needs of large workspace and large load capacity. Through the comparative analysis of dynamic and virtual prototype simulation, the reduction force of the designed reduction robot can reach 200 N. The experimental results show that the robot not only has the characteristics of high precision and high load of parallel robot, but also has the characteristics of large workspace of series robot.
Development of an ice-jam flood forecasting modelling framework for freeze-up/winter breakup
Authors: Das Apurba , Budhathoki Sujata , Lindenschmidt Karl-Erich
Published: April 2023

River ice-jams can create severe flooding along many rivers in cold regions. While ice-jams often form during the spring breakup, the mid-winter breakup can cause ice-jamming and flooding. Although many studies have already been focused on forecasting spring ice-jam flooding, studies related to forecasting mid-winter breakup jamming and flooding severity are sparse. The main purpose of this research is to develop a stochastic framework to forecast the severity of mid-winter ice-jam flooding along the transborder (New Brunswick/Maine) Saint John River of North America. A combination of hydrological (MESH) and hydraulic model (RIVICE) simulations was applied to develop the stochastic framework. A mid-winter breakup along the river that occurred in 2018 has been hindcasted as a case study. The result shows that the modelling framework can capture the real-time ice-jam severity. The results of this research will help to improve the capacity of ice-jam flood management in cold regions.
Introdução ao dossiê.
Authors: Lira Bruno , Medeiros Rogério
Published: April 2023

Introdução
A Elite Cultural do Folclore "Alemão" Autêntico no Brasil
Authors: Voigt Lucas
Published: April 2023

No Brasil, um conjunto de agentes atua na definição, preservação e promoção do folclore alemão “autêntico” e legítimo. Este artigo tem por objetivo analisar as práticas e as estratégias de legitimação da elite cultural folclorista, isto é, do conjunto de agentes que ocupa as principais posições no espaço de práticas do folclore “alemão” no Brasil. Para tanto, são enfocadas três questões-chave: (1) as instâncias de recrutamento e de formação da elite cultural folclorista; (2) o trabalho de mediação cultural levado a cabo pelos especialistas em folclore, que consiste na decodificação de fontes históricas produzidas no contextoeuropeu e na prescrição de práticas e condutas no espaço do folclore brasileiro, procedimento basilar à legitimação e à garantia da “autenticidade” do folclore; e (3) os principais caracteres de origem social, trajetória, capitais e trunfos sociais disponíveis à elite cultural folclorista e/ou adquiridos por meio do seu investimento na esfera do folclore.
Rotas Alteradas
Authors: Lima Antonio , Zimmermann Clóvis Roberto
Published: April 2023

O objeto deste artigo é analisar a formação, o desenvolvimento e a expansão,na Região Metropolitana de Salvador – RMS e no interior do estado,de um mercado de drogas ilegais submetido ao controle de organizaçõescriminais locais, inter-relacionadas com grupos homônimos, origináriosdo Norte, Centro-Oeste e Sudeste do país. Trata-se de uma análise longitudinal,que abrange o período entre o final da década de 1990 aos dias correntes.Os resultados apresentados descrevem o desenvolvimento de umaconformação organizacional hierarquizada, belicosa, com divisão funcionale de formato exclusivista, que se tornou preponderante, expandindosuas redes comerciais nesse intervalo de tempo. No sentido de possibilitara compreensão da atual configuração das dinâmicas organizacionais ilegais,territorializadas, belicosas e baseadas no recurso universal à violência,foram elencados seus elementos explicativos fundamentais, como orecrudescimento de políticas punitivistas, o consequente encarceramentoem massa, a ausência de cobertura legal e institucional em áreas pobres esegregadas e as transformações na lógica geral do mundo do crime, com aampliação de uma rede nacional de fluxos criminais materiais e imateriais.
Demographic Factors and Their Impact on the Development of Pension System in Russia
Authors: Frumina S. V.
Published: April 2023

The development of the state pension system of the Russian Federation is accomplished within the frames of Strategy-2030 and oriented towards attaining national goals and UN Targets of Sustainable Development. According to requirements of strategic documents parameters of the pension system shall be connected with basic macroeconomic and demographic indicators that can both stimulate and restrict its development. As the pension system is fully integrated in the national finance system, its functioning depends directly on finance relations between participants (employees, employers, the Pension Fund of Russia (PFR) and federal budget). However, demographic factors, such as life-span, gender structure, dynamics of birth and death, etc. act as a limiter of finance relations. The article studies changes in demographic factors and finds the trend of population aging, which could have an adverse effect on pensions of Russian citizens. Irrespective of organizational structure of the pension system and amalgamation of two biggest non-budget funds demographic problem is still an important component that affects pension provision. After-effects of the pandemic, forced relaxation and growing life expectancy of the population decreases the gap between the number of working population and the number of pensioners (coefficient of age dependence), which can result in the necessity to look for additional stimulus to the development of the pension system and raising welfare of pensioners. The goal of the article is to substantiate the trend of demographic aging of the population, which leads to higher load on the pension system.
Prospects of Carbon Regulation in Russia and Raising Enterprise Responsibility and Involvement in Work Aimed at Cutting Green-House Gas Emissions
Authors: Brizhanin V. V. , Filippova R. V. , Kiseleva S. P. , Ostah S. V.
Published: April 2023

One of the key challenges of the current century is the growth in green-house gases emissions to the atmosphere. The concentration of carbonic acid gas in the Earth atmosphere keeps rising, which results in climate change. Climate change in Russia can be characterized as continuous warming and its speed is in 2.5 times higher than the speed of global warming. It can prove the volume of our country contribution to the total green-house gas emissions, which shall be taken into account for developing steps aimed at resolving national climatic problems. Ecology in current circumstances and in long-term perspective means practical and scientific and technical foundation for the beginning of man’ rational life on the Earth, when negative impact on the environment is reduced and at the same time accumulated damage is eliminated. Disregard for climatic agenda can create risks for sustainable development of national economy. This principle was introduced in the concept of sustainable development, which is based on balance between human activity and laws of nature by replacing consumers’ attitude towards nature. The article studies the widely-spread economic (market) mechanisms of carbon regulation. General and specific measures of motivating low-carbon development were discussed aiming at higher responsibility and involvement of enterprises in work on cutting green-house gas emissions. The authors show that the key economically effective tools for cutting the carbon footprint are the system of trading quotas on green-house gas emissions, the development of the national system of stock-taking, accounting and emission monitoring. It can be realized as a result of substantiating national emission factors, logical and normative approaches and tested methods for estimation of green-house gas emissions, improvement of the quality of data being analyzed and scenario modeling.
Imitation Modeling of Production Processes in FlexSim Environment
Authors: Lapteva E. V. , Lekareva Yu. S. , Umansky S. S.
Published: April 2023

Modeling systems in present day life give opportunity to find optimum ways of enterprise functioning and changes in set parameters without interference in production processes or before starting the planned production. The article studies imitation modeling use in agricultural machine-building. Brief description of FlexSim software is provided. Functional features of the system of imitation modeling allow users to identify bottlenecks, analyze statistic data, plot diagrams, etc. Imitation models of production processes on assembly line for seed-loaders are described, obtained results are analyzed and bottlenecks of the production line are identified. The authors study possibilities of optimization, which can raise productivity, for example, cutting the number of operators and introducing coordinators. The present research shows the importance of modeling and analyzing production processes in virtual environment in order to plan changes in production. Apart from modeling production processes, FlexSim program can be used for analyzing material, finance, information, staff resources, which affects managerial decision-making and strategy of industrial enterprise development.
Managerial Tools Used in Business-Processes Re-Engineering
Authors: Temukuev T. B.
Published: April 2023

The article studies processes and methods used in case re-engineering of business-processes at the enterprise is necessary. Forward approach to re-engineering is grounded, which identifies its several stages and highlights key characteristics of managerial tools used there. Methods of analyzing efficiency of processes taking place in creating value (product, service, work) are shown. The author traces the way from the hypothesis of the necessity of process re-engineering to analyzing the final result and checking it for compliance with the strategic plan. Key tools of managing the process are shown and their efficiency is described as applied to business-processes in oil and gas industry. The feasibility of using functional-value, plan-factorial and structural analysis is studied. The research puts forward and corroborates the hypothesis that to realize re-engineering of evolutionary and revolutionary types it is necessary to use all three mentioned above methods, as they complement each other and it is also advisory to use data gained by one method in another one. On the basis of the analysis it is possible to conclude that this system of methodology can be used in restructuring business-processes connected with marketing and innovation activity at enterprises of the fuel and power-engineering complex in Russia.
Challenges and Prospects of Rite Tourism in Russian Regions
Authors: Pavlova Yu. Yu.
Published: April 2023

The article analyzes processes influencing current trends of tourism development. The author focuses on principle importance of in-country tourism, its adjustment to present day conditions and thinks that it is necessary to find new vectors and lines of its development. He proposes to pay special attention to the development of rite tourism as a possible solution to current problems. This notion has not been highlighted in academic literature yet. The author analyzes this type of tourism and puts forward his own interpretation and classification of its key lines as well as classification of rite tours in time, length and geography. He underlines the difference between rite tourism and ritual one. The analysis of the most popular routes showed that our country possesses necessary resources for the development of rite tourism. The author studied the potential, for example of the Arkhangelsk region and proposes to use certain folk fests of coast-dwellers to develop new tourist programs within the frames of rite tours. The fullscale use of the rite tourism potential as an integral part of tourist industry can have serious impact on social and economic progress in the region, on preservation of cultural traditions and our history.
Paradoxical Emergence of the Food Security Problem in Times of Current Challenges: from the General to the Particular
Authors: Maksimova T. P.
Published: April 2023

Complete satisfaction of essential needs of the population is a key factor of any economic system sustainability.The article studies specific features of the food security problem, identifies paradoxes of its emergence, focuses on attaining quality parameters in resolving problems of food security. The author carries out comparative analysis of certain aspects of global and national food security and investigates implementation of the Food Security Doctrine of the Russian Federation. The multi-aspect character of the food security problem was grounded and the necessity of its systematic study was underlined. Apart from that, the article provides hypothetic forecasts that current trends of dominance of big economic forms in the structure of agricultural produce output could cause serious structural changes in the whole economic system, reduce the importance of market mechanisms and result in decreasing biodiversity in food supply.
Finance Policy of the Company Based on Adapted System of Assessment within the Frames of Strategic Management
Authors: Plakhotnikova M. A. , Anisimov A. Yu. , Kashirtseva A. Yu. , Suslova M. A.
Published: April 2023

The article studies the concept, methods and forms of assessment of finance strategy in the company, which could promote its development. The authors pay special attention to issues dealing with finance policy in Russian companies. The goal of the research is to analyze theoretical basis of finance policy assessment and summarizing the most serious pre-conditions for its effective pursuance within the frames of strategic management of the company. The subject of the research is methods of appraisal and conditions of finance policy pursuance within the frames of strategic management of the company. The authors used the following methods in their research: statistical methods, comparative analysis of sources, synthesis of academic knowledge and some specific methods, i. e. finance analysis and algorithmization. As a result the authors put forward recommendations on choosing efficient methodology for finance policy assessment and on the list of conditions necessary for its successful realization within the frames of strategic management of the company.
Linarin Ameliorates Diabetic Liver Injury by Alleviating Oxidative Stress and Inflammation through the Inhibition of AKR1B1
Authors: Wang Tong , Shan Meng-ya , Tang Cui-yao , Cheng Mao-yuan , Chen Bin , Yan Jun , Xu Zi-hui
Published: April 2023

Aims:

The study aims to find a new functional additive for diabetic liver injury.

background:

It is well-established that type 2 diabetes mellitus (T2DM) is a metabolic disease with multiple complications. Linarin (LN) is a natural flavonoid isolated from Asteraceae and Lamiaceae, which has beneficial effects on metabolic diseases such as nonalcoholic steatohepatitis (NASH) and diabetes.

Background:

It is well-established that type 2 diabetes mellitus (T2DM) is a metabolic disease with multiple complications and places a significant health and economic burden on modern society. Linarin is a natural flavonoid isolated from Asteraceae and Lamiaceae, which has beneficial effects in preventing and treating metabolic diseases such as nonalcoholic steatohepatitis and diabetes.

Objective:

We aimed to investigate the pharmacological effect and underlying mechanism of linarin on T2DM-associated liver injury in vivo and in vitro.

method:

Using a high glucose high palmitic acid-induced hepatocyte injury model and a type 2 diabetic rat model.

Methods:

Using a high-glucose and high-palmitic acid-induced hepatocyte injury model and a type 2 diabetic rat model. Following linarin treatment, serum biochemical parameters, liver histology, and lipid profiles of rats were examined. Oxidative stress index and inflammatory response were detected in vivo and in vitro. The expression level of AKR1B1 in rat liver tissues and in vitro cells was detected by western blot and by real-time fluorescent quantitative PCR.

Results:

The present study found that linarin could prevent oxidative stress and inflammation. In high-fat-fed diabetic rats, linarin administration (15, 30, and 60 mg/kg/day) reduced hepatic lipid accumulation, oxidative stress, and inflammation. Linarin (20 μM) significantly alleviated oxidative stress, inflammation, and apoptosis induced by high glucose combined with palmitic acid in LX-2 cells. Western blotting and overexpression experiments showed that these effects were related to AKR1B1 inhibition in vivo and in vitro.

conclusion:

LN could protect against liver injury in T2DM by alleviating oxidative stress and inflammation mediated by AKR1B1. Our findings suggest that LN has huge prospects as a new functional additive for a healthy diet.

Conclusion:

This study indicated that linarin could protect against liver injury in T2DM by alleviating oxidative stress and inflammation mediated by AKR1B1 and may be a promising additive for diabetic liver injury therapy.
The Antibacterial Effects of Healing Abutments Coated with Gelatincurcumin
Nanocomposite
Authors: Negahdari Ramin , Mahin Tina , Torab Ali , Maleki Dizaj Solmaz , Sharifi Simin
Published: April 2023

Introduction:

For the long-term success of implant treatment, prevention of biological complications,
including pre-implant diseases, plays an important role. The use of antimicrobial coatings is
one of the prosperous methods in this field. The aim of this study is to evaluate the antimicrobial effects
of healing abutments coated with gelatin-curcumin nanocomposite.

Method:

This study included 48 healing abutments in the form of a control group (titanium healing
abutments without coating) and an intervention group (titanium healing abutments coated with gelatincurcumin
nanocomposite). The disc diffusion method was used to evaluate the antimicrobial effects of
coated healing abutments against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis
and the results were reported in a non-growth zone area.

Results and Discussion:

Gelatin-curcumin nanocomposite caused significant non-growth aura for all
three bacteria compared to the control group. For the control group (healing abutments without coating),
the antimicrobial effects (non-growth zone) were zero. Besides, gelatin-curcumin nanocomposite had
the greatest inhibiting effect on the growth of S. aureus, then E. coli and finally E. faecalis.

Conclusion:

The results of our study showed that the coating used was able to significantly demonstrate
a non-growth zone against all three bacteria compared to the control group without coating. Further
evaluations in various physicochemical, mechanical, and antimicrobial fields are necessary for the animal
model and clinical phase.
Experimental investigation of the fluid-structure interaction during deep drawing of fiber metal laminates in the in-situ hybridization process
Authors: KRUSE M.
Published: April 2023

Abstract. Matrix accumulations, buckling and tearing of fibers and metal sheets are common defects in the deep drawing of fiber metal laminates. The previously developed in-situ hybridization process is a single-step method for manufacturing three-dimensional fiber metal laminates (FML). During the deep drawing of the FML, a low-viscosity thermoplastic matrix is injected into the dry glass fiber fabric layer using a resin transfer molding process. The concurrent forming and matrix injection results in strong fluid-structure interaction, which is not yet fully understood. To gain a better understanding of this interaction and identify possible adjustments to improve the process, an experimental form-filling investigation was conducted. Using a double dome deep drawing geometry, the forming and infiltration behavior were investigated at different drawing depths with full, partial, and no matrix injection. Surface strain measurements of the metal blanks, thickness measurements of the glass fiber-reinforced polymer layer, and optical analyses of the infiltration quality were used to evaluate the results.
Electrically-assisted deep drawing of 5754 aluminium alloy sheet
Authors: DOBRAS D.
Published: April 2023

Abstract. The effect of current pulse application on the mechanical behaviour and plasticity of the 5754 aluminium alloy was studied. Tensile and deep drawing tests were conducted. The 5754 aluminium alloy in two different states of hardening was used: H111 and H22. The results show that the application of current pulses can significantly increase the plasticity of the examined alloys in the case of the tensile test. The dynamic recovery process is the main process responsible for the increase in plasticity of the material. However, in the case of the deep drawing process, it was observed that the increase in the material formability is low, and further studies are needed.
Mechanical and microstructural properties of AISI 4140 after flow-forming process
Authors: YAZGAN E.
Published: April 2023

Abstract. Flow-forming is a cold deformation process to form dimensionally precise and rotationally symmetrical parts. Strain hardening effect of the flow forming process, and possibility of producing cylindrical part are the advantages especially for aerospace industry. The purpose of this study is to investigate the effect of initial microstructure of an AISI 4140 steel on the microstructure and mechanical properties after being flow formed by 70% as the reduction ratio in the thickness direction. In this context, as-received steel was heat treated to standard quenched and tempered condition, and an additional annealing was also performed. Before and after the flow forming process, the microstructure was examined, hardness and tensile tests were conducted. The results revealed that the additional annealing was beneficial to obtain a crack free material after the flow forming process of a heat treated material.
An ANN based approach for the friction stir welding process intrinsic uncertainty
Authors: QUARTO M.
Published: April 2023

Abstract. Friction Stir Welding is a solid-state bonding process that during last years has caught the researcher's attention for the mechanical characteristics of the welded joints that are quite similar to the properties of the base material. The Friction Stir Welding is affected by several process parameters leading to intrinsic variability in the process. The present paper would introduce a new approach for predicting the surface hardness in different areas of the welded parts. Specifically, this method is based on the hypothesis that multiple Artificial Neural Networks, characterized by the same architecture but different weights, can be used for forecasting both the punctual value of the local hardness and its confidence interval, resulting in taking into account the intrinsic variability of the process.
Sensitivity analysis of the of the square cup stamping process using a polynomial chaos expansion
Authors: PEREIRA A.F.G.
Published: April 2023

Abstract. The stochastic modelling and quantification of the various sources of uncertainty associated with sheet metal forming processes, usually requires a large computational cost to obtain accurate results. In this work, a polynomial chaos expansion metamodel is used in order to reduce the computational cost of the uncertainty quantification (through Sobol’s indices). The metamodel allows to establish mathematical relationships between the square cup forming results and the uncertainty sources associated with the material behaviour and process conditions. Then, sensitivity indices are estimated with the trained metamodel, without resorting to additional numerical simulations. The indices obtained with the metamodel were compared to those obtained with the traditional approach based on a quasi-Monte Carlo method. The metamodel allowed to reduce the computational cost in about 90% when compared to the traditional approach, without compromising the accuracy of the results.
Modeling of surface hardening in burnishing process
Authors: TEIMOURI R.
Published: April 2023

Abstract. In the present paper, a multiphysic model was developed to identify the underlying mechanism of surface layer hardening in burnishing of stainless steel 304. The mechanic of burnishing process was firstly modeled to obtain deformation parameters i.e. strain and strain rate by incremental plasticity. Then the strengthening mechanisms were identified association of constitutive equations regarding twinning-induced hardening and phase change. It was found that the twining-induced hardening has greatest contribution in strengthening the surface layer. Moreover, among the process parameters, the burnishing depth has greatest effect on hardness magnitude and corresponding depth.