bluuebunny/crossref_metadata_2025 huggingface dataset:
Sigmatism in the Prooemium of Nemesianus’ Cynegetica
Authors: Kucz Anna , Gryksa Edyta
Published: June 2022

Phonetic dramatization is an aesthetic procedure used in the late-classical poetics, which aimed at releasing various emotions “in the density of letters itself”. The phenomenon of ancient sigmatism, i.e. the accumulation of consonants in a particular verse of a poem, is going to be outlined at the very beginning of this article. Then sound effects will be discussed, mainly those based on the analysis of sigmatism present in the prooemium of the treaty on hunting entitled Cynegetica. The abovementioned poem was written by Nemesianus, a Carthaginian poet living in the second half of the 3rd century AD. The article is an attempt to determine whether there is any connection between the phonetics and the meaning of the analysed poem. Moreover, the article’s authors would like to answer the question if repeated use of ‘s’ in particular verses of the Cynegetica prooemium proclaims negative events or shocking emotions
The Chemistry and Pharmacology of Genistein
Authors: Atiya Fatima  , Ram Singh
Published: June 2022

Genistein is a natural compound belonging to the chemical class of isoflavone. This molecule is present in the significant portion of our diet in the form of Soy food products. This is the most extensively studied isoflavone due to its significance affinity towards targets of potential pharmacological and neutraceutical benefits. The potential pharmacological applications of this molecule have been found as anti-cancer, anti-obesity, anti-diabetic, neuroprotective, antiosteoporosis, and cardio protective agent. This review provides comprehensive coverage of the chemistry, pharmacology, toxicity and extraction of genistein.
“Cadê o Museu?” Reflexões Sobre o Impacto da Pandemia nos Espaços Culturais e Educadores Surdos de Museus
Authors: Garcia Maria Izabel dos Santos , Cabral Rebeca Garcia , Silva Bruno Ramos da
Published: June 2022

Vivemos em um contexto histórico marcado por mudanças sociais e educacionais. Nesse novo cenário social, é cada vez mais necessário trabalhar as questões que dizem respeito à inclusão de grupos marginalizados. Os surdos vêm se organizando há anos por meio de associações e instituições com diferentes finalidades. A diversificação na forma em que os grupos de surdos se organizaram vem ganhando novas dimensões nos últimos anos e, atualmente, os museus e outros espaços culturais são locais que vêm sendo reivindicados por essa comunidade. Cada vez mais aumenta o número de educadores surdos em museus e visitas mediadas em língua de sinais. Com isso, novas estratégias são pensadas para uma efetiva mediação para o público surdo e, principalmente, para viabilizar a participação efetiva de crianças surdas em espaços culturais, de forma a apresentar a importância da inserção da educação artística nos ensinos fundamental e médio para crianças/adolescentes surdos. Contudo, a pandemia de COVID-19 representou um impacto nesses desenvolvimentos pelo fechamento dos museus e de outros espaços culturais no período de isolamento social. Este artigo se propõe a investigar como a pandemia gerou mudanças na dinâmica dos espaços culturais, especialmente no caso do Brasil, e como essas novas ações virtuais mobilizaram os educadores surdos de museus.
Aproximações e Distanciamentos. Vítimas de Catástrofes em Brumadinho: A Engenharia de um Crime e Tragédia em Mariana
Authors: Pinheiro Carlos Henrique , Antunes Elton
Published: June 2022

Neste artigo, abordamos dois livros-reportagem que tratam de catástrofes ocorridas no Brasil, recentemente: Tragédia em Mariana, de Cristina Serra (Record, 2018) e Brumadinho: A Engenharia de um Crime, de Lucas Ragazzi e Murilo Rocha (Letramento, 2021). Embora estes trabalhos compartilhem similaridades tais como aspectos formais e temáticos, entendemos que indiciam diferentes modos de apreensão jornalística do mundo, com distintas implicações éticas particularmente no que concerne ao modo como as personagens vítimas dessas catástrofes emergem nas reportagens. Consideramos que os personagens jornalísticos têm dupla existência: no texto e fora dele, e é uma responsabilidade ética refletir sobre as formas como são constituídos tendo em vista possíveis passagens entre um e outro. Propomos então discutir, valendo-nos das duas obras, os modos de aproximação jornalística com tais acontecimentos a partir de três dimensões analíticas articuladas. No tópico “Marcas de Escuta e Presença Autoral”, damos atenção a indícios de como os autores e autora apuraram as informações que constam em seus livros, colocando sua escuta junto às vítimas ou apurando outros registros das catástrofes. Em “Personagens (S)em Enredo”, discutimos quem são aqueles cujas histórias são contadas nesses livros, como isso se faz e com que possíveis efeitos. Em “Projeto e Paratextos”, abordamos as intenções declaradas por cada autor-repórter, bem como o quanto exploram ou não as potencialidades de um livro-reportagem no aspecto específico do desenvolvimento de personagens. Por fim, cotejamos abordagens de outros repórteres sobre as representações de seus personagens para pensar como cada autor-repórter das obras que analisamos aqui se posiciona diante da catástrofe e que tipo de registro jornalístico sua postura reflete.
PENGARUH KEMAMPUAN AKUNTANSI PERUSAHAAN DAGANG, BAHASA INGGRIS, DAN FASILITAS LABORATORIUM KOMPUTER TERHADAP HASIL BELAJAR KOMPUTER AKUNTANSI
Authors: Sartika Ratna Dewi Ayu
Published: June 2022

AbstrakTujuan penelitian yakni membuktikan adanya pengaruh kemampuan akuntansi perusahaan dagang, bahasa inggris dan fasilitas laboratorium komputer secara simultan dan parsial terhadap hasil belajar komputer akuntansi. Penelitian ini menggunakan aplikasi MYOB yang diterapkan pada mata pelajaran akuntansi perusahaan dagang. Jenis penelitian ini merupakan penelitian kuantitatif. Sampel penelitian adalah kelas XII AKL di SMK Negeri 10 Surabaya sejumlah 102 siswa sebagai responden dengan teknik pengambilan sampel menggunakan purposive sampling. Kuesioner dan dokumentasi dipergunakan dalam pengumpulan data. Perolehan uji F menunjukkan Fhitung (9,142) dan nilai signifikansi (0.000) sehingga diartikan kemampuan akuntansi perusahaan dagang, kemampuan bahasa inggris dan fasilitas laboratorium komputer berpengaruh secara simultan terhadap hasil belajar komputer akuntansi perusahaan dagang. Perolehan uji t membuktikan 1) kemampuan akuntansi perusahaan dagang berpengaruh positif dan signifikan terhadap hasil belajar komputer akuntansi perusahaan dagang; 2) kemampuan bahasa inggris berpengaruh positif dan signifikan terhadap hasil belajar komputer akuntansi perusahaan dagang; dan 3) fasilitas laboratorium komputer berpengaruh positif dan signifikan terhadap hasil belajar komputer akuntansi perusahaan dagang.Kata Kunci: Akuntansi Perusahaan dagang, Bahasa Inggris, Fasilitas Laboratorium.AbstractThe research objective is to prove the impact of trading company accounting capabilities, English language and computer laboratory facilities simultaneously and partially toward learning outcomes of accounting computer. This study uses the MYOB application which is applied to the trading computer accounting subjects. This type of research is quantitative research. The research sample was class XII AKL at SMK Negeri 10 Surabaya with 102 students as respondents and using purposive sampling as a sampling technique. Questionnaires and documentation are used in data collection. The acquisition of the F test proves Fcount (9,142) and significance value (0,000) so that the accounting capabilities of a trading company, English language abilities and computer laboratory facilities simultaneously affect the learning outcomes of a trading company accounting computer. The acquisition of t test proves that 1) the company's accounting ability has a positive and significant effect on the learning outcomes of computer accounting firms; 2) English ability has a positive and significant effect on the learning outcomes of trading computer accounting companies; and 3) computer laboratory facilities have a positive and significant effect on the learning outcomes of computer accounting firms.Keywords: Company accounting skills, English, Laboratory Facilities.
PENGEMBANGAN MEDIA “ECCAPY” BERBASIS ANDROID PADA KOMPETENSI DASAR JURNAL PENYESUAIAN PERUSAHAAN DAGANG SEBAGAI UPAYA MENINGKATKAN MOTIVASI BELAJAR
Authors: Istiqomah Febriana Putri , Aghni Rizqi Ilyasa
Published: June 2022

Tujuan penelitian ini yaitu: mengembangkan Media Pembelajaran Akuntansi “Eccapy”; mengetahui tingkat kelayakan media “Eccapy” dari penilaian para ahli dan guru pembelajaran (praktisi); mengetahui respon pengguna media “Eccapy”; mengetahui meningkatnya motivasi belajar setelah penggunaan media pembelajaran. Penelitian ini menggunakan jenis penelitian pengembangan dengan model ADDIE. Hasil penelitian menunjukkan tingkat kelayakan Media “Eccapy” berdasarkan: 1) Ahli Media menunjukan rerata hasil 3,99 dan dikatakan Layak, 2) Ahli Materi menunjukan rerata hasil 4,38 dan dikatakan Sangat Layak, dan 3) Praktisi pembelajaran menunjukan rerata hasil 4,08 dan dikatakan Layak. Penilaian kelayakan media berdasarkan respon pengguna menunjukan rerata hasil 4,25 dan dikatakan Sangat Layak. Pada pengujian motivasi belajar dihasilkan Sig. = 0,0000,05 yang dapat artinya ada perbedaan yang signifikan antara kelas kontrol tanpa penggunaan media dan kelas eksperimen dengan penggunaan media.
ВПЛИВ КОМБIНОВАНОГО ХIРУРГIЧНОГО ЛIКУВАННЯ НА ФУНКЦIОНАЛЬНУ АКТИВНIСТЬ ЩИТОПОДIБНОЇ ЗАЛОЗИ У ХВОРИХ НА ПIСЛЯОПЕРАЦIЙНИЙ РЕЦИДИВНИЙ ЗОБ
Authors: Караченцев Юрій , Хазієв Вадим , Дубовик Віктор , Лях I. О. , Герасименко Леонід , Гопкалова I. В , Сазонов Є. В.
Published: June 2022

Спостереження за станом хворих на пiсляоперацiйний рецидивний зоб показує високу частоту гiпотиреозу як пiсля стандартного хiрургiчного втручання, так и пiсля операцiї з використанням iнтраоперацiйного дозованого крiовпливу. Локальний крiовплив на тканину щитоподiбноїзалози привоздить до затримки згасання тиреоїдної функцїї, що реалiзується у меньшiй частотiпiсляоперацiйного гiпотиреозу. Проте можна прогнозувати зростання частоти i тяжкостi гипотиреозу у вiддаленi строки пiсля операцiї, що пов’язано як з механiчним видаленням значноїчастки тиреоидної паренхiми, так i з пошкоджуючим ефектом аутоiмунного процесу в залишкахтиреоидної паренхiми.
FEATURES OF DIAGNOSIS OF NON-ALCOHOLIC FAT LIVER DISEASES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO ULTRASOUND INVESTMENT DATA
Authors: Kravchun N. A. , Zemlyanitsina O. V. , Tyazhelova O. V.
Published: June 2022

230 patients with type 2 diabetes mellitus (DM) were examined, of which 83 were diagnosed with non-alcoholic fatty liver disease (NAFLD) (36.1%). It is established that NAFLD is reliable

more common in obese and overweight patients (54.5 and 37.5%, respectively)

and only in 20.8% of patients with normal body weight. Among patients with type 2 diabetes with normal

body weight NAFLD is more common in women, and in overweight and obesity -

in men. Patients with type 2 diabetes and NAFLD, regardless of body weight, have abdominal

type of adipose tissue deposition. Changes in the size and structure of the pancreas in patients

with type 2 diabetes do not depend on changes in body weight and, most likely, develop comorbidly

with type 2 diabetes.
FEATURES OF ULTRASOUND INVESTIGATION THYROID GLAND IN PATIENTS WITH RECURRENCE NODAL NON-TOXIC GOAT
Authors: Tyazhelova O. V. , Khaziev Vadym
Published: June 2022

According to the ultrasound examination of patients with postoperative recurrent goiter, it was found that the signs for recurrence of single-node goiter are: oval shape of the tumor with clear contours, reduced echogenicity, absence of calcifications and fluid component, clear capsule. To optimize the tactics of surgical treatment of patients with nodules

pathology of the thyroid gland, it is necessary to use intraoperative ultrasound examination of the neck, especially in multinodular goiter, when performing organ-preserving operations, as well as in malignant pathology of the thyroid gland, to detect pathological changes.

nodes of the neck.
FEATURES OF HORMONAL HOMEOSTASIS EARLY CHILDREN WITH CARDITAS RUNNING IN THE BACKGROUND CYTOMEGALOVIRUS INFECTION
Authors: Lezhenko G. O. , Borisenko T. V.
Published: June 2022

The hormonal status of children with carditis has been studied. The interdependence of the formation of myocardial dysfunction and changes in the indicators of neurohumoral regulation is shown. In early children

age with carditis there is a new metabolic status, which is formed in the conditions of adaptation at

myocardial hypoxia and elevated left ventricular filling pressure, which is an adaptive-compensatory reaction.
MICROCIRCULAR CHANGES IN CHILDREN WITH OBESITY
Authors: Chumak S. O.
Published: June 2022

The study analyzed the nature of microcirculatory disorders (MP) in 304 children and

adolescents and the influence on the microcirculation of various factors inherent in obesity. In 74% of children and

Adolescents with obesity have microcirculation disorders of varying degrees, in half of patients (51%) due to preclinical changes and functional MP, including 22.5% of patients

disorders of moderate severity of sympathetic-atonic form are revealed. It is shown that it is important

Insulin resistance (IR), hyperinsulinemia, have a place in the formation of MP in obesity.

hypertriglyceridemia and abdominal obesity, in the presence of which more severe functional disorders of microcirculation predominate in 70% of patients.
FEATURES OF THE REPRODUCTIVE FUNCTION OF MALE - DESCENDANTS MOTHERS WHICH WERE STRESSED AT THE BEGINNING OF PREGNANCY AND THEY RECEIVED VITAMIN E
Authors: Kartavtseva O. V.
Published: June 2022

The peculiarities of the reproductive function of male rats, whose mothers experienced social and emotional stress in the first third of pregnancy on the background of the use of vitamin E. The possibility of preventive therapy of functional disorders of reproduction in the offspring by using the offspring.
AGE PECULIARITIES OF STRUCTURE OF THE TYPE 2 DIBETES MELLITUS RISKFACTOR IN THE CO-WORKERS OF MEDICAL ORGANIZATION OF KHARKIV
Authors: Ilyina I. M. , Kazakov Alexandr , Misyura Katerina , Zubko M. I. , Belecka O. M.
Published: June 2022

Comparative analysis of frequency and strength of the type 2 diabetes mellitus risk factors in the groups of people younger than 45 years old, 45 years old and older has been conducted. It was established that above factors in the group of people younger than 45 are observed less frequently than in the older people group, but rather frequently for taking them into consideration when organizing and funding prophylactic programs.
TYPE 1 DIABETES MELLITUS COMPENSATION AND FACTORS OF CHILDREN AND ADOLESCENT DISORDERS (literature review and own data)
Authors: Budreyko E. A.
Published: June 2022

The chronic natural nature of the sugar diabet (DD) determines the undeniable social significance of this disease, which has become grounds for planning and executing in the last decade of large multicenter scientific researches, the development of comprehensive practical recommendations, the creation of numerous consensuses for early diagnosis, the optimization of CD. , profilation of the emergence and progression of the most dangerous His hazards - chronic diabetic complications (Eurodiab, 2001, DCCT / EDIC, 2005, AACT / ADA CONSENSUS STATEMENT ON INPATIENT GLYCEMIC CONTROL, 2009)
FUNCTIONAL CONDITION OF TESTIS IN INFERTILE MEN WITH HYPOTHYROIDISM IN THE PRESENCE OR ABSENCE OF AUTOIMMUNE THYROIDITIS
Authors: Spivak J. S. , Bondarenko Volodymyr
Published: June 2022

Spermograms parameters and testosterone blood levels were studied in infertility hypothyroid men in the presence or absence of autoimmune thyroiditis. Abovementioned indices were assessed also in infertility patients with autoimmune thyroiditis and euthyroidism. It was established autoimmune thyroiditis availability in hypothyroid men was accompanied by significant increase in spermatozoa agglutination level. Moreover, decreased testosterone blood level was revealed in most of hypothyroid patients irrespective of presence or absence of autoimmune thyroiditis.
LIVER FUNCTION AND ANDROGENIC STATUS IN MEN WITH IDIOPATHIC PATHOSPERMIAS
Authors: Bondarenko Volodymyr , Minukhin Andriy , Skorniyakov Evgeniy
Published: June 2022

Transaminase levels, the total and direct bilirubin, as well as androgenic status indicators in men with idiopathic pathospermias, patients with hypogonadism and practically healthy subjects were analysed. It was established, that alaninaminotransferasa and aspartataminotransferasa enhanced levels were accompanied by decrease in total testosterone and increase in estradiol levels in men with idiopathic sperm concentration defect. Aborementioned patients showed also more essential reduction of free androgen index also more essential reduction of sizes of free androgen index is marked. We revealed slight increase in transaminase levels in men with hypogonadism.
HORMONAL MARKERS OF DEVELOPMENT OF ARTERIAL HYPERTENSION IN ADOLESCENTS WITH OBESITY
Authors: Lezhenko G. A. , Gladun E. V.
Published: June 2022

The aim of the study was to analyze of hypertension epidemiology in adolescents with obesity. 36,15 % of adolescents with obesity revealed the presence of arterial hypertension by measuring the level of «office» blood pressure. It was established that the main factors that contributed to the development of arterial hypertension were hyperleptinaemia, insulin resistance and activation of the RAAS.
THE IMPACT OF 17β-ESTRADIOL ON THE HEME OXYGENASE ACTIVITY AND TBA-ACTIVE PRODUCTS LEVEL IN VESSELS OF OVARIECTOMIZED RATS WITH INSULIN RESISTANCE
Authors: Kiprych Tetiana , Nikitchenko I. V. , Gorbenko Nataliia
Published: June 2022

The effect of 17β-estradiol on the heme oxygenase activity and TBA-active products level in vessels of  variectomized rats with insulin resistance was investigated. Insulin resistance induced by high fructose diet in ovariectomized rats led to increase in heme oxygenase activity and TBA-active products level in vessels. Administration of 17β-estradiol prevented increase in heme oxygenase activity and TBA-active products level, that could be explained by amelioration of insulin resistance and normalization of prooxidant-antioxidant state and could be considered the one of possible mechanisms of vasoprotective estradiol effect.
TOTAL AND HIGH MOLECULAR WEIGHT ADIPONECTIN IN TYPE 2 DIABETIC PATIENTS WITH REGARD TO GENDER, GLYCEMIC CONTROL AND INSULIN RESISTANCE LEVEL
Authors: Gorshunska Maryana
Published: June 2022

The article reviewed world literature data along with own study findings regarding different multimeric adiponectin complexes, their functional activity and contribution of high molecular weight adiponectin as the most biologically active multimeric configuration in total adilponectin level in Type 2 diabetic patients. Usage of ratio «high molecular weight adiponectin / total adiponectin» for insulin sensitivity characteristic are discussed. In accordance with own findings significance of endogenous hyperinsulinemia for hypoadiponectemia development was verified without modulatory glycemic control impact but with gender differences preservation in Type 2 diabetic patients.
OXIDATIVE STRESS IN PATHOGENESIS OF DIABETIC MICRO- AND MACROANGIOPATHY AS A TARGET FOR THERAPEUTIC IMPACT
Authors: Poltorak V. V. , Krasova Nataliya , Gorshunska Maryana
Published: June 2022

The review is devoted to the pathogenic role of oxidative stress in speciﬁc and nonspeciﬁc diabeticvascular complications development. Perspectives of antioxidant therapy, in particular, α-lipoic acid,in order to restore redox homeostasis and eliminate the negative consequences of its imbalance aregrounded.
Vascular anomalies
Authors: Biagioni Luísa Ciucci
Published: June 2022

Vascular anomalies are complex diseases with different clinical presentations. In ancient times, some purplish spots were already seen as a curse, and over the centuries, they began to be described as part of other diseases, gaining different eponyms. In recent decades, the term "hemangioma" has been missused to describe a large part of vascular anomalies, causing a significant problem in diagnosing and treating patients.
Effects of the exercise mobile app and distance supervision on the functional performance of the older adults. Protocol of a clinical, randomized, controlled trial.
Authors: Kunitake André Issao , Dias Keoma Santos , Vegh Henrique Pereira , Ramos Leticia Garcia , Bossert Victor Gonçalves , Bezzera Hitanna dos Santos , Solai Maria Jucilane Soares , Corrêa Fernanda Ishida
Published: June 2022

Objective: To check the effects of the exercise mobile app with face-to-face and distance supervision on the functional performance, postural balance, and lower limb strength of older adults. Methods: This is a protocol of a controlled, randomized, and blind clinical trial in which we will recruit older adults of both genders, who will be randomized into two types of training: a control group (exercises using a mobile app with face-to-face monitoring by the therapist) and an experimental group (exercises with a mobile app without face-to-face monitoring by the therapist). The training will be carried out with the free app "Exercício para idosos", which should be installed on the participants' smartphones. The participants should do the proposed exercises three times a week for eight consecutive weeks. The evaluations will be conducted in person pre-training and after the 12th and 24th sessions. Functional performance, postural balance, and lower limb strength will be assessed. The data in each evaluation will be compared as well as the difference between the groups. It is believed that physical exercise apps for older people will benefit both groups by improving functional capacity, postural balance, and lower limbs of older adults.
Dispersal of hydrogen in the retina – a three-layer model
Authors: Mansoor Wafaa , Hocking Graeme Charles , Farrow Duncan
Published: June 2022

Two simple mathematical models of advection and diffusion of hydrogen within the retina are discussed. The work is motivated by the hydrogen clearance technique, which is used to estimate blood flow in the retina. The first model assumes that the retina consists of three, well-mixed layers with different thickness, and the second is a two-dimensional model consisting of three regions that represent the layers in the retina. Diffusion between the layers and leakage through the outer edges are considered. Solutions to the governing equations are obtained by employing Fourier series and finite difference methods for the two models, respectively. The effect of important parameters on the hydrogen concentration is examined and discussed. The results contribute to understanding the dispersal of hydrogen in the retina and in particular the effect of flow in the vascular retina. It is shown that the predominant features of the process are captured by the simpler model.
 
doi: https://doi.org/10.1017/S1446181122000050
Explicit Nordsieck second derivative general linear methods for ODEs
Authors: Ramazani Paria , Abdi Ali , Hojjati Gholamreza , Moradi Afsaneh
Published: June 2022

The paper deals with the construction of explicit Nordsieck second derivative general linear methods with \(s\) stages of order \(p\) with \(p=s\) and high stage order \(q=p\) with inherent Runge–Kutta or quadratic stability properties. Satisfying the order and stage order conditions together with inherent stability conditions leads to methods with some free parameters, which will be used to obtain methods with a large region of absolute stability. Examples of methods with \(r\) external stages and \(p=q=s=r-1\) up to order five are given, and numerical experiments in a fixed stepsize environment are presented.
 
doi: https://doi.org/10.1017/S1446181122000049
Health Protocol Compliance Monitoring Integrated System during COVID-19 Pandemic in Indonesia (Preprint)
Authors: Manikam Logan , Aisyah Dewi Nur , Kiasatina Thifal , Naman Maryan , Adisasmito Wiku , Kozlakidis Zisis
Published: June 2022

BACKGROUND

The COVID-19 cases are soaring in Asia. Indonesia, Southeast Asia’s most populous country is now on the second rank in Asia, just after devastating India. The compliance towards mask wearing, keeping a social distance and hand washing needs to be monitored to assess public behavioral changes that can reduce transmission.

OBJECTIVE

This study aims to evaluate this compliance in Indonesia between October 2020 and May 2021; and to demonstrate the use of Bersatu Lawan COVID (BLC) mobile application in in monitoring the compliance.

METHODS

Data was collected in real-time by the BLC app from reports submitted by personnel of the military services, policies, and behavioral change ambassadors. Then, the data was analyzed automatically by the system managed by Indonesia National Task Force for the Acceleration of COVID-19 Mitigation.

RESULTS

Between 1 October 2020 and 2 May 2021, the BLC app has generated more than 165 million reports, with 469 million people were monitored, and 124,315,568 locations were under observation in 514 districts/cities in 34 provinces in Indonesia. This paper groups them into four colored zones, based on the degree of compliance and analyses variations among regions and locations.

CONCLUSIONS

Compliance rates vary among the 34 provinces, and among districts and cities of those provinces. However, compliance to mask wearing seems slightly higher than social distancing. This suggest policy makers need to promote higher compliance in other measures, including social distancing and hand washing, whose efficacies have been proven to break the chain of transmission, when combined with masks wearing.
Shared Interoperable Clinical Decision Support Service for Drug-Allergy Interaction Check: Implementation Study (Preprint)
Authors: Yi Byoung-Kee , Jung Sungwon , Bae Sungchul , Seong Donghyeong , Oh Ock Hee , Kim Yoomi
Published: June 2022

BACKGROUND

Clinical decision support (CDS) can improve healthcare with respect to the quality of care, patient safety, efficiency, and effectiveness. Establishing a CDS system in a healthcare setting remains a challenge. A few hospitals have used self-developed in-house CDS systems or commercial CDS solutions. Since these in-house CDS system tends to be tightly coupled with a specific EHR system, the functionality and knowledge base are not easily shared. A shared interoperable CDS system facilitates sharing knowledge base and extension of CDS services.

OBJECTIVE

The study develops and deploys the national CDS service for the drug-allergy interaction (DAI) check for healthcare providers that need to introduce the service but lack budget and expertise in Korea.

METHODS

To provide the shared interoperable CDS service, we designed and implemented the system based on the CDS Hooks® specification and HL7® (Health Level 7) FHIR® (Fast Healthcare Interoperability Resources) standard. The study describes the CDS development process. The system development went through the requirement analysis, design, implementation, and deployment. In particular, the concept architecture was designed based on the CDS Hooks structure. The MedicationRequest and AllergyIntolerance resources were profiled to exchange data using the FHIR standard. The discovery and DAI check APIs and rule engine were developed.

RESULTS

The CDS service was deployed on G-Cloud, a government cloud service. In March 2021, the CDS service was launched, and 67 healthcare providers participated in the CDS service. The healthcare providers participated in the service with 1,008,357 DAI checks for 114,694 patients, of which 33,054 cases resulted in a "warning" (3.32%).

CONCLUSIONS

Korea's Ministry of Health and Welfare has been trying to build an HL7 FHIR-based ecosystem in Korea. As one of these efforts, the CDS service initiative has been conducted. To promote the rapid adoption of the HL7 FHIR standard, it is necessary to accelerate the practical service development and appeal the benefits of FHIR standardization to policymakers. With the development of various case-specific implementation guides (IGs) using the KR Core IG, the FHIR standards will be distributed nationwide, and more shared interoperable healthcare services will be introduced in Korea.
Eating Disorders “Maze Out”: A pilot study to evaluate the feasibility of a serious game co-produced by patients and therapists. (Preprint)
Authors: Guala Maria , Bul Kim , Skårderud Finn , Søgaard Nielsen Anette
Published: June 2022

BACKGROUND

Eating disorders are severe mental disorders associated with notable impairments in quality of life. Despite the severity of the disorders and extensive research in the field, effective treatment for eating disorders is lacking.

OBJECTIVE

The aim of this study is to describe and evaluate the usability of Maze Out, a Serious Game co-produced by patients and therapists, and to explore the acceptability of Maze Out among patients suffering from eating disorders.

METHODS

The present study is a qualitative study, collecting data through focus groups and individual interviews, including user analytics collected through the game. Participants were recruited from Odense Mental Health Service of Region South Denmark. We used the mobile health evidence reporting and assessment (mERA) checklist to describe and evaluate the usability of the game, supplemented with user-analytics collected through the game. Eighteen patients and a therapist participated in the qualitative interviews that were interpreted by IPA (Interpretative Phenomenological Analysis) which resulted in a co-produced Serious Game prototype, Maze Out.

RESULTS

The participants found Maze Out engaging, easy to use and a good platform to reflect on their disorder. They primarily used Maze Out as a conversational tool with their significant others and give them insight into experiences and daily life struggles for someone suffering from eating disorders.

CONCLUSIONS

: Maze Out seems to be a promising tool as an addition to Eating Disorders treatment. Further research should focus on evaluating the effectiveness of the game and its potential to support patients with different kind of eating disorders patients.
Barriers and Facilitators Influencing Real-Time & Digital Based Reporting of Adverse Drug Reactions by Community Pharmacists: a qualitative study using the Task Technology Fit Framework (Preprint)
Authors: Fossouo Tagne Joel , Yakob Reginald  Amin , Mcdonald Rachael , Wickramasinghe Nilmini
Published: June 2022

BACKGROUND

Spontaneous reporting of suspected Adverse drug reaction (ADR) is central to monitoring post-licensure medication safety. Underreporting by health professionals is highly prevalent across the world. Little is known about how community pharmacists (CPs) recognises and report to surveillance systems in Australia.

OBJECTIVE

Explore the perceptions of CPs towards pharmacovigilance (PV) and identify factors associated with ADR reporting to help inform future interventions designed to improve ADR underreporting.

METHODS

A qualitative study with individual interviews was conducted with 12 CP’s working across Victoria, Australia between April 2022 and May 2022. A semi-structured interview guide was used to identify experienced barriers and facilitators to ADR reporting. Data was analysed following thematic analysis. Themes within barriers and facilitators were aligned with the Task-Technology Fit (TTF) framework.

RESULTS

Lack of knowledge was a key driver in low awareness to PV or reporting systems and work environment/ resources were key drivers in the lack of time to report by CPs in Australia. To facilitate the ADR reporting process, multifaceted digital reporting systems should be developed within the pharmacist workflow, utilising auto-population features with integrated ADR report feedback systems.

CONCLUSIONS

In contrast to previous studies and prior interventions that attempted to address ADR underreporting, we theorise that it is not the end-users (CPs) that need behavioural change through more enticements or enforcement, but rather that the work practices and technologies that support their work need to be altered. Understanding the nature of “lack of time to report” may serve useful to design more targeted interventions strategies, the first relating to the organisational/workplace structure and the later, operational/ IT infrastructure. Implementing new digital technologies such as mobile apps and artificial intelligence supporting both active and passive surveillance present as opportunity to empower consumer reporting and reducing CPs workload.
Resistance gene expression in selected Indonesian pigmented rice varieties against infection by Xanthomonas oryzae pv. oryzae
Authors: Nadhira Nur Elia , Wafa Ali , Fanata Wahyu Indra Duwi , Addy Hardian Susilo
Published: June 2022

Rice (Oryza sativa L.) production is limited by bacterial leaf blight (BLB), caused by Xanthomonas oryzae pv. oryzae (Xoo). For decades, researchers have attempted to control this disease by growing plants with blight‐resistant Xa genes. Genetic resources often vary between rice varieties, and there is little information about the genetic resources of the pigmented rice varieties widely grown in Indonesia and their resistance genes against Xoo. The purpose of this study was to determine the expression of Xa genes in pigmented rice such as Inpari 24 and Cempo Merah (red‐pigmented) along with Hitam Bantul (black‐pigmented) and white rice varieties IR64 and Ciherang, and to evaluate their resistance to BLB. All varieties carried the Xa4, Xa10 and xa13 genes but varied in the Xa1, Xa7 and Xa21 genes. The rice varieties expressed some of these genes only after inoculation with Xoo. Disease assessment categorised the three different pigmented rice varieties as resistant (Ciherang, Cempo Merah and Hitam Bantul), while IR64 (white) and Inpari 24 (red) were moderately resistant. There was no specific pattern of Xa genes possession, quality of expression or resistance level to X. oryzae pv. oryzae. Therefore, when breeding plants, the selection of parental variety must be considered in terms of the possession and expression of Xa genes such as Xa10 as a molecular marker for resistance.
Analysis of Covid-19 Cash Direct Aid (BLT) Acceptance Using K-Nearest Neighbor Algorithm
Authors: Aldino Ahmad Ari , Suryono Ryan Randy , Ambarwati Riyama
Published: June 2022

During the COVID-19 pandemic, the government imposed Large-Scale Social Restrictions (PSBB) to reduce or slow down the spread of COVID-19. This causes people to be unable to work as usual, and not even a few people have lost their jobs. This prompted the government to launch the Covid-19 direct cash assistance (BLT) program. One of the areas affected by the PSBB is Batu Ampar Village, which distributing BLT is considered less effective by residents because there are BLTs that are not well-targeted. The cause of the ineffectiveness of the distribution of aid was assessed because the data was out of sync; it was difficult to verify and validate the new data due to the size of the area and the constantly changing number of underprivileged residents. To overcome these problems, a model is needed to predict the recipients of this Covid-19 BLT. This study uses the K-Nearest Neighbor (K-NN) algorithm and RapidMiner tools to make predictions and validate using Cross-Validation. The data used are 711 lines with 474 training data and 237 testing data resulting in an accuracy of 89.68% for training data and 88.61% for testing data.
Indonesia’s Political Position on the Protection Policy of Migrant Workers in ASEAN
Authors: Dwi Eriyanti Linda , Hadi Makmur Muhammad , Ayu Intansari Diah
Published: June 2022

As a sending country of migrant workers in ASEAN, Indonesia has a weaker bargain than the receiving countries. This is in line with the thoughts of Marxist Feminism arguing that within the structure of a capitalist society, the owners of the capital, in which context are the receiving countries, have more power to control the factors of production. Indonesia has weak bargaining power, so Indonesia's political position in protecting its migrant workers in ASEAN has never changed. It has always been a follower country. One instance of the studies investigating the position was conducted by Amelia (2013) with their political position indicator. The researcher divides the country’s political position into the first country, the follower country, the satellite country, and the independent country. This study aims to examine Indonesia’s political position in the protection policies of Indonesian migrant workers in ASEAN. This study is framed by qualitative method with case study and interpretative analysis. The results of this study indicate that Indonesia’s political position on its migrant worker protection policies can be categorized into a follower country.
The Effects of Pesticides on Humans and the Environment
Authors: Martins Moises da Silva , Oliveira Helena Cassia de
Published: June 2022

This article highlights the use of chemical agents in agriculture, which undoubtedly causes a series of environmental impacts when used improperly and puts health and human life at risk. In a methodological, qualitative, bibliographic and exploratory way, with research in magazines and books specialized in the subject, it shows the bottlenecks of pesticides, in addition to highlighting possible problems that the ecosystem faces in the face of the indiscriminate use of these products. The article also seeks to show the serious consequences that the indiscriminate use of agrochemicals can bring to the environment, when used without information and knowledge, showing in the conclusion the importance of having environmental awareness. The present study brings a review of scientific reports of impacts of pesticides on the environment and human health. Human beings are subject to direct and daily exposure to these chemical compounds in the areas of production, treatment and storage of products, and indirectly, but with no less serious consequences for being exposed to residues found in the environment and in products consumed, so in a clear and objective way environmental preservation and education are fundamental.
Prevalence of Apical Periodontitis in a Public Dental Service in Northern Brazil
Authors: Araújo Laíssa Gualberto Silva de , Marques Larissa Macedo , Rosa Ana Claudia Garcia , da Cruz Eduardo Zambaldi , Senna André Machado de
Published: June 2022

Apical periodontitis (AP) is characterized by a peri-root inflammatory process presented by the host's immune response, from infections that affect the root canal system. The objective of this study was to verify the prevalence of apical lesions in digital periapical radiographs performed in a public dental care service in the northern region of Brazil. To this end, 3967 digital periapical radiographs performed on patients seen in 2019 were analyzed and classified using the Ørstavik periapical index (PAI). A total of 7172 teeth were analyzed. Four hundred and twenty-one of these teeth had already received endodontic treatment with root filling. The prevalence of AP in teeth without endodontic treatment was equivalent to 14.6%. In teeth with TE, the prevalence was 33.5%. The overall prevalence, when at least one tooth of an individual had apical periodontitis, was 49.9%. The prevalence found was lower than the reported worldwide prevalence, but still considered high in this specific population and indicates the need for directing public policies to improve this condition.
Racial Trauma and Microaggression in Toni Morrison’s The Bluest Eye
Authors: Routray Dr. Deepshikha , Kuanr Jayasmita
Published: June 2022

Racial trauma is associated with the detrimental psychological impact of race-based discrimination having symptoms like those of Post-Traumatic Stress Disorder (PTSD). With accounts of systemic racism across the globe, it is quite pertinent to discuss the distressing impact of living within a society of structural racism. Racial trauma involves exposure and re-exposure to race-based stress, which can be of different forms, microaggression being one of them. Microaggression shows how instances at a micro-level like insults and slights against black people, can have a detrimental effect on the mental health of those who experience it. The Bluest Eye (1970), the debut novel of Nobel prize-winning author Toni Morrison, is a tragic story of Pecola Breedlove, an African- American girl, longing for the socially constructed idea of beauty. A study of her character will highlight the effects of internalised racism based on the tragic events of discrimination and marginalisation in Pecola’s life and her psychological response to it. This paper will focus on racial trauma and Chester E. Pierce’s concept of microaggression to foreground the psychological distress that Pecola is grappling with, in the narrative and how apart from acts of violence, offensive and derogatory statements against the people of colour damages their psyche.
Dhvani Theory in Indian Aesthetics
Authors: Singh Ajay
Published: June 2022

Two texts have made significant contributions to Indian Aesthetics throughout the history of Indian literary criticism: Dhvanyāloka by Ānandavardhana and Locana, a commentary on the first text by Abhinavagupta. Both works have had a direct or indirect influence on all Indian Sanskrit critics. One of Ānandavardhana’s significant contributions is that he incorporates emotions and other association meanings into language meaning. As a result, the poetics expanded on conceptions of primary and secondary meaning. Given that Ānandavardhana was influenced by Bharathari, the proponent of the sphota theory, he highlighted the need of considering the entire utterance as an important unitary linguistic symbol. He had also demonstrated that the meaning of an utterance is influenced by context, and that the logical interpretation of meaning of a sentence based on individual word meanings is often fallacious. He also asserted that the overall meaning of an utterance may differ from the meaning of the individual words. Bharathari influenced Ānandavardhana to build his theory of language, but his attempt was limited to poetic meaning. In this research article, we shall make an attempt to comprehend the suggestive sense, also known as dhvani, along with its various forms, as described by Ānandavardhana.
Consideraciones sobre la transmisión plena inter vivos de la propiedad privada sobre la tierra en Cuba.
Authors: Milian Gómez Jorge Freddy , Rodríguez Corría Reiniero
Published: June 2022

The results of the research carried out on the inter vivos transmission of private property on land are presented, which has extraordinary relevance in the current Cuban context, due to the changes taking place in society, especially from the legal point of view. Far from being an analysis that criticizes the way in which the administrative authorities act in agrarian matters, this report aims to systematise the main forms of full inter vivos private land ownership transmission in Cuba. The aim is to show how, on the basis of such action, a proper regime for transfer of agricultural property has been created which contributes to Agricultural Law autonomy. The theoretical definitions of inter vivos private property transmission on land and agricultural goods are presented, as well as an assessment of the possibility of transmission of privately owned land in the Cuban legal system and related contractual figures. The legal research methods used are legal theoretical and legal analysis. The result is a coherent systematisation of transfer of ownership contracts in the agricultural sector.
Simulation of Stress tests using a Poroelastic model to estimate the Permeability behavior of bedford limestone samples
Authors: Vadillo-Sáenz Mario E. , Díaz-Viera Martín A. , Domínguez-Torres Aarón , Serrano-Saldaña Enrique , Coronado Manuel
Published: June 2022

Por su relevancia en Geociencias, el efecto de los esfuerzos sobre las propiedades de flujo de fluido en rocas ha sido estudiado experimental y teóricamente por varias décadas. Los trabajos se han orientado principalmente a rocas tipo arenisca, y relativamente poco, a pesar de su relevancia, en rocas carbonatadas. Por otro lado, la descripción del fenómeno es matemática y numéricamente complejo, ya que involucra el acoplamiento no lineal del flujo de fluido con la deformación de la roca. En este trabajo se busca incursionar en esa parte poco explorada de pruebas experimentales en carbonato y su simulación numérica.En él se presentan pruebas experimentales realizadas en núcleos de caliza Bedford, y se analiza el efecto de los esfuerzos de confinamiento y de la presión del fluido (presión de poro) sobre la permeabilidad a través de dos tipos de pruebas, conocidas como hidrostáticas (bajos esfuerzos de corte) y no hidrostáticas (altos esfuerzos de corte). En este trabajo se presenta un modelo matemático para describir el fenómeno, considerando un fluido monofásico, una respuesta elástica de la roca, y su implementación numérica en elementos finitos.El acoplamiento del flujo de fluido con los esfuerzos se modela utilizando relaciones algebraicas de porosidad y permeabilidad en función del esfuerzo. La relación permeabilidad-esfuerzo utilizada en este trabajo depende linealmente de la deformación volumétrica y la presión de poro. Los resultados experimentales muestran que en general la permeabilidad se incrementa con la presión del fluido y se reduce con el esfuerzo de confinamiento. La reducción con el esfuerzo de confinamiento en el rango de esfuerzos de confinamiento analizado es relativamente pequeña, pero es notoriamente más importante en las pruebas no-hidrostáticas (8%) que en las hidrostáticas (2%).El ajuste del modelo a los resultados experimentales, específicamente a la caída de presión en el núcleo en función del tiempo, se realiza mediante la variación de los parámetros de la relación permeabilidad-esfuerzo. El valor de estos parámetros de ajuste difiere del valor reportado para areniscas, lo cual puede ser indicativo de la diferencia en la estructura porosa y las propiedades mecánicas de las rocas.
Gamma-ray spectrometry applied in the identification of potential acid mine drainage generation zones in waste rock pile with uranium ore and associated sulfides (caldas, Brazil)
Authors: Gastmaier Marques Anna Carolina , Moreira César Augusto , Stanfoca Casagrande Matheus Felipe , Aldana Arcila Erika Juliana
Published: June 2022

La minería de metales modifica profundamente la dinámica ambiental local y produce grandes volúmenes de roca y residuos, los cuales se espera sean eliminados cuidadosamente para evitar el deterioro del suelo, el agua y el medio ambiente. La mina Osamu Utsumi fue un sitio de explotación de mineral de uranio pionero en Brasil, ubicado en el estado de Minas Gerais. La mina abierta y la alta concentración de sulfuro en las capas de material estéril son hoy en día un tema de preocupación para las Industrias Nucleares de Brasil (INB), debido a la oxidación del sulfuro y el drenaje ácido de la mina resultante (AMD, por sus siglas en inglés).El objetivo de esta investigación es analizar los datos de espectrometría de rayos gamma y la generación de AMD en una capa de material estéril, BF-04, en el sitio. La adquisición de datos radiométricos combinada con estudios previos indica que las altas concentraciones de uranio y torio están asociadas con zonas de alto contenido de sulfuro.El mineral de uranio mineralizado incluye sulfuros que se destruyen rápidamente por las condiciones de hidratación de la superficie y son responsables de generar el drenaje ácido de la mina. En este sentido, las zonas superficiales de la capa de material estéril con altos niveles de eU y eTh son áreas expuestas a la oxidación e hidratación de sulfuros y, por lo tanto, su reconocimiento y neutralización pueden contribuir a disminuir la generación de AMD en el sitio de estudio y áreas con condiciones similares.Los resultados de la espectrometría de rayos gamma pueden ser de interés para una remediación de bajo costo en el entorno local.