bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of stable host-plant resistant sources to sterility mosaic disease of pigeonpea (Cajanus cajan L. Huth)
Authors: MEDIGA KASI RAO , SUNKAD GURURAJ , SHARMA MAMTA
Published: September 2024

Sterility mosaic disease (SMD) presents a major challenge in pigeonpea cultivation throughout the Indian subcontinent. Chemical control methods, such as acaricides, are neither economically viable nor sustainable, making host plant resistance the preferred approach for managing this disease. In this study, we evaluated 45 pigeonpea germplasm accessions and breeding lines for SMD resistance over two consecutive Kharif seasons (2021-22 and 2022-23). Of the 45 genotypes tested, 8 exhibited low disease incidence (0-10%) (LRG-471, ICPL 151, ICPB 2089, ICPB 2047, ICPB 2092, ICPB 2211, ICPL 85063, and ICPL 14003) and were classified as resistant. Additionally, 23 genotypes showed disease incidence between 10.1-20.0% and were categorized as moderately resistant. These resistant genotypes offer promising new sources of SMD resistance and should be considered for inclusion in future pigeonpea breeding programs aimed at improving resistance. This research provides valuable phenotypic insights and identifies stable resistant sources essential for advancing SMD resistance breeding efforts.
Pirolisis Campuran Biji Jarak Dan Biji Kapuk Dengan Katalis Zeolit Menjadi Syngas Dan Biochar
Authors: Syahputri Syahputri Aprellia , Irawan Rusnadi  , Ida Febriana
Published: September 2024

Sumber energi terbarukan yang ramah lingkungan dapat berasal dari biji jarak dan biji kapuk. Biomassa dari biji jarak dan biji kapuk memiliki nilai kalor masing-masing sebesar 8498 kal/gr dan 5758 kal/gr. Metode pirolisis dapat digunakan untuk mengkonversi biomassa tersebut menjadi sumber energi diantaranya biochar dan syngas. Dalam hal ini, dilakukan penelitian dengan metode pirolisis yang bertujuan untuk menentukan pengaruh penggunaan jumlah katalis serta perbedaan rasio bahan baku biji jarak dan biji kapuk terhadap syngas untuk dilakukan perbandingan penelitian ini dengan penelitian sejenis dan biochar dengan mengacu pada standar mutu SNI 1683:2021. Metode yang digunakan dalam penelitian ini berupa metode eksperimental dari variabel bebas dan terikat yang tergolong kedalam data primer. Variabel bebas diantaranya variasi rasio biji jarak dan biji kapuk serta jumlah katalis zeolit, sedangkan variabel terikat yaitu massa bahan baku dan temperatur operasi. Sementara itu, data sekunder diperoleh dari hasil penelusuran kepustakaan. Produk syngas yang diperoleh dianalisis komposisi syngas dengan multi gas detector analyzer, sedangkan pada produk biochar dilakukan analisis proksimat dan nilai kalor. Pada penelitian ini diketahui bahwa, perbedaan rasio bahan baku serta peningkatan jumlah katalis dari 3% menjadi 5% berpengaruh terhadap produk hasil pirolisis. Pada produk biochar, diperoleh nilai kalor tertinggi sebesar 6513,46 kal/gr di variasi komposisi 50% biji jarak, 50% biji kapuk, dan 5% katalis. Hasil tersebut telah memenuhi standar arang kayu SNI 1683:2021. Pada syngas, diperoleh persentase CH4 tertinggi di variasi komposisi 75% biji jarak, 25% biji kapuk, dan 5% katalis  yaitu 45%.
Assessing the efficacy of anti-cancer drugs on organoid models derived from prostate cancer
Authors: Silkina M. O. , Razumovskaya A. V. , Nikulin S. V. , Tonevitsky A. G. , Alekseev B. Ya.
Published: September 2024

It has been proven that tumor organoids effectively mirror the phenotypic and genetic traits of the original biomaterial. It has been noted that outcomes from drug testing in organoid cultures can accurately represent the clinical response observed in patients. In this study, an organoid culture was derived from biopsy material of prostate cancer (PC). Subsequently, clinical practice drugs, docetaxel and enzalutamide, were tested on this organoid culture. Various techniques for evaluating the efficacy of drugs in vitro were compared. The half maximal inhibitory concentration of docetaxel was found to be markedly lower compared to that of enzalutamide. However, when tested at clinically relevant concentrations and incubation times, enzalutamide was more effective than docetaxel. Therefore, it is crucial to optimize the testing conditions for drugs on in vitro cultures for their subsequent application in clinical practice.
Aberrant repair of 8-oxoguanine in short DNA bulges
Authors: Eroshenko D. A. , Diatlova E. A. , Golyshev V. M. , Endutkin A. V. , Zharkov D. O.
Published: September 2024

The presence of DNA damage can increase the likelihood of DNA replication errors and promote mutations. In particular, pauses of DNA polymerase at the site of damage can lead to polymerase slippage and the formation of 1–2 nucleotide bulges. Repair of such structures using an undamaged DNA template leads to small deletions. One of the most abundant oxidative DNA lesions, 8-oxoguanine (oxoG), has been shown to induce small deletions but the mechanism of this phenomenon is currently unknown. We have studied the aberrant repair of oxoG, located in one- and two-nucleotide bulges, by the Escherichia coli and human base excision repair systems. Our results indicate that the repair in such substrates can serve as a mechanism for fixing small deletions in bacteria but not in humans.
Otu and Rif1 double mutant enables analysis of satellite DNA in polytene chromosomes of ovarian germ cells in Drosophila melanogaster
Authors: Kolesnikova T. D. , Nokhova A. R. , Shatskikh A. S. , Klenov M. S. , Zhimulev I. F.
Published: September 2024

Polytene chromosomes in Drosophila serve as a classical model for cytogenetic studies. However, heterochromatic regions of chromosomes are typically under-replicated, hindering their analysis. Mutations in the Rif1 gene lead to additional replication of heterochromatic sequences, including satellite DNA, in salivary gland cells. Here, we investigated the impact of the Rif1 mutation on heterochromatin in polytene chromosomes formed in ovarian germ cells due to the otu gene mutation. By the analysis of otu11; Rif11 double mutants, we found that, in the presence of the Rif1 mutation, ovarian cells undergo additional polytenization of pericentromeric regions. This includes the formation of large chromatin blocks composed of satellite DNA. Thus, the effects of the Rif1 mutation were similar in salivary gland and germ cells. The otu11; Rif11 system opens new possibilities for studying factors associated with heterochromatin during oogenesis.
The sensory structures of the carapace of male Tantulocarida are not homologous to the lattice organs of Thecostraca
Authors: Savchenko А. S. , Kolbasov G. A.
Published: September 2024

For the first time, ultrastructural studies have been conducted on the sensory apparatus of male Tantulocarida (Crustacea). Comparative morphological analysis with specialized sensory structures of Thecostraca, known as lattice organs, has allowed for conclusions about possible homologies and further clarification of the phylogenetic position of Tantulocarida
Seeds treatment with salicylic acid increases gene expression and activity of antioxidant enzymes in wheat plants under zinc or copper deficiency
Authors: Kaznina N. M. , Repkina N. S. , Batova Yu. V. , Ignatenko А. А. , Titov A. F.
Published: September 2024

The effect of wheat seeds treatment with salicylic acid (SA) on the expression of the TaCu/ZnSOD, TaFeSOD and TaCAT2 genes and the activity of antioxidant enzymes (superoxide dismutase (SOD) and catalase (CAT)) in leaves at the optimal content of zinc (2 µM) and copper (0.3 µM) in root environment or there deficiencies has been studied. It was shown for the first time that seeds treatment with SA leads to an increase of the number of genes transcripts compared to untreated plants, both under optimal conditions of mineral nutrition and under zinc or copper deficiency. The activity of enzymes, especially catalase, also increases. Judging by the MDA content, this allows one to avoid increasing the intensity of lipid peroxidation (LPO) and, accordingly, the development of oxidative stress. It is concluded that the discovered positive effect of seed treatment with SA on the activity of the main enzymes of antioxidant system may underlie the stimulating effect of this phytohormone on physiological processes in plants under microelements deficiency.
Experimental and model study of swirling fluid flow in a converging channel as a simulation of blood flow in the heart and aorta
Authors: Zharkov Ya. Е. , Zhorzholiani Sh. T. , Sergeev А. А. , Agafonov A. V. , Gorodkov A. Y. , Bockeria L. A.
Published: September 2024

The study of swirling flows in channels corresponding to the static approximation of flow channels of the heart and major vessels with a longitudinal-radial profile zR2 = const and a concave streamlined surface at the beginning of the longitudinal coordinate has been carried out. A comparative analysis of the flow structure in channel configurations zRN = const, where N = –1; 1; 2; 3, in the absence and presence of a concave surface was carried out. The numerical modelling was compared with the results of hydrodynamic experiments on the flow characteristics and the shape of the flow lines. The numerical model was used to determine the velocity structure, viscous friction losses and shear stresses. Numerical modelling of steady-state flows for channels without a concave surface showed that in the channel zR2 = const there is a stable vortex flow structure with the lowest viscous friction losses. The presence of a concave surface of sufficient size significantly reduces viscous friction losses and shear stresses in both steady state and pulsed modes.
COMPARISON OF THE PHYSICAL FITNESS OF WATER RESCUE GUARDS FROM RURAL AND URBAN AREAS
Authors: KOWALSKI Damian , TSYHANOVSKA Nataliia , SKALSKI Dariusz W. , KREFT Paulina
Published: September 2024

The work is of a research nature. The aim was to determine the level of physical development and motor skills of students aged 10-11 from two different environments: rural and urban. Physical development was determined based on height and weight. The Rohrer index was calculated and the Kretschmer typological system was used. The International Physical Fitness Test was used to assess the level of physical fitness. The test results indicate that women from rural areas showed a higher level of fitness tests than girls from the city. However, in the case of boys, the tests showed a similar level of fitness. After calculating the results, all groups were in the average physical fitness range. However, the points obtained allowed the conclusion that both women and men from rural areas have better physical fitness than their peers from the city. The purpose of the fitness test is to objectively assess the development of motor skills, general performance and physical fitness as well as technical skills. Such tests can be used individually and in groups. They can be performed at any age. The tests were developed mainly for rescuers aged 18-25, because most rescuers work in this age group.
PENGARUH KARAKTERISTIK BANK TERHADAP PROFITABILITAS BANK DI INDONESIA
Authors: Eston Maria Albertina Dewanti , Muslim Ahmad , Widiastuti Maria C
Published: September 2024

Studi dilakukan dengan meneliti pengaruh karakteristik bank terhadap profitabilitas, diproksikan dengan Return on Assets, dengan rasio kecukupan modal, simpanan, pinjaman, likuiditas, kredit bermasalah, dan ukuran bank sebagai variabel independent serta moderasi kredit bermasalah terhadap modal. Hasil penelitian dengan menggunakan analisis regresi menunjukkan bahwa simpanan, pinjaman, kredit bermasalah dan ukuran bank memiliki efek signifikan terhadap profitabilitas, sedangkan rasio lain tidak berpengaruh. Temuan ini menunjukkan pentingnya pengelolaan dana pihak ketiga dan penyaluran kredit yang berhati-hati serta kecukupan asset bank untuk meningkatkan profitabilitas.
Evaluasi Pelaksanaan PILKADA Serentak Tahun 2020 di Kabupaten Yalimo
Authors: Yabansabra Rudolf , Torobi Renida J.
Published: September 2024

This article analyzes the assessment of the implementation of the 2020 Yalimo Regency elections using three indicators: effectiveness, efficiency, and responsiveness. The research uses a qualitative approach through a literature study, drawing data from various sources such as journal articles, government reports, and news. The data analysis includes categorization, presentation, and making conclusions. The results show that the implementation of the regional elections in Yalimo Regency is not optimal. In terms of effectiveness, disputes, riots, and re-voting problems were identified. The organization of the elections is considered highly inefficient due to budget irrationality and increased costs after the discourse of re-voting and riots. The responsiveness aspect shows both positive and negative responses to decisions made during the elections.
Pertumbuhan Ekonomi Masyarakat Adat di Wilayah Perkebunan Kelapa Sawit Kabupaten Keerom
Authors: Siriwa Semuel , Silo Akbar , Tebay Vince , Torobi Renida J.
Published: September 2024

This article analyzes the impact of the development and expansion of oil palm plantation companies on the socio-cultural and economic transformation of indigenous peoples in Keerom District, Papua Province. The study aims to analyze the changes that have occurred in the social structure, cultural practices, and economic systems of indigenous peoples, as well as identify factors that affect their economic conditions after the entry of oil palm plantations. This article uses qualitative research with a descriptive approach. The study was conducted in villages scattered by oil palm plantations in Keerom District. The research instruments used were recording devices and notebooks. Data collection techniques included in-depth interviews and observation. Data analysis includes the stages of data reduction, data presentation, and conclusion drawing or verification. The results show that the presence of oil palm plantations has resulted in significant erosion of traditional practices and customary land tenure systems. The transformation of the ecological landscape has resulted in the loss of access to natural resources that have been the economic and spiritual basis of the community. The shift from a subsistence economy to a wage-based economy has changed social dynamics and family structures.
STUDENTS' ATTITUDES ABOUT CODE-MIXING IN PRACTICING SPEAKING
Authors: Humaira Rizka , Jamaliah  , Ramlan
Published: September 2024

Mastering the English language offers numerous opportunities to effectively communicate one's thoughts, feelings, and ideas to a broader audience. Speaking can be difficult because speakers must develop phrases on the spot. This qualitative research aimed to investigate students’ attitudes towards code mixing in spoken language practice through semi-structured interviews. Five students from Jeumala Amal Islamic Senior High School were interviewed as participants because of their frequent use of code-mixing in daily conversations. The results indicated that students' positive attitudes towards code mixing helped them build confidence in speaking English and become more accustomed to using the language as a part of their regular communication habits.
STUDENTS’ PERSPECTIVE TOWARD THE IMPLEMENTATION OF GOOGLE FORM AS A DIGITAL LEARNING ASSESSMENT TOOL
Authors: Nursani  , Zaiturrahmi  , Diana Novita
Published: September 2024

The purpose of this research is to describe students' perspectives on the implementation of Google Forms as a digital assessment tool. This research uses a qualitative research design. Data collection was carried out through questionnaires and interviews. The research participants were 20 students in the second grade at Dassa Al-Aziziyah Islamic Senior High School. Data from 20 questions were distributed, and interviews with eight students were analyzed. Results were produced regarding students' perspectives on implementing Google Forms as a digital learning assessment tool. The research results showed that students have a positive perspective on using Google Forms from attractiveness, effectiveness, convenience, and efficiency. The efficiency aspect allows students to know the score directly. Thus, this provides efficiency and accuracy to the assessment system. Additionally, it makes it easy for students to answer questions by clicking on the answer rather than circling the question. Moreover, mandatory questions help students to fill in all the questions before submitting the test. Therefore, this will ensure that questions are answered. However, students have a negative perspective on using Google Forms regarding accessibility.
Middle School Mathematics Problem Solving Ability Reviewed From Students' Learning Interests
Authors: Pitriyani Dina Ciski , Afriansyah Ekasatya Aldila
Published: September 2024

The reality in the field shows that students' ability to solve problems is still relatively high. This research aims to determine mathematical solving abilities in terms of students' interest in learning social arithmetic material at SMPN 1 Cikajang. The population in this study were middle school/MTs students of the same level, while the sample was selected based on a purposive sampling technique of 3 students. Analysis of the results of this research shows that mathematical problem-solving abilities are viewed from students' learning interests: (1) All three students' interest in learning is classified as high with each student's problem-solving ability varying in the high, very high, and medium categories (2) The level of student interest in learning tends to affect the level of students' problem-solving abilities. First students who have a high category level interest in learning tend to have high mathematical problem-solving abilities. The second student who has a high level of interest in learning tends to have very high mathematical problem-solving abilities and the third student who has a high level of interest in learning tends to have moderate mathematical problem-solving abilities.
Kenyataan di lapangan menunjukkan bahwa kemampuan siswa dalam pemecehan masalah masih tergolong tinggi. Tujuan penelitian ini adalah untuk mengetahui kemampuan pemecahan matematis ditinjau dari minat belajar siswa materi aritmatika sosial di SMPN 1 Cikajang. Populasi dalam penelitian ini adalah siswa SMP/MTs sederajat yang berada, sedangkan sampel dipilih berdasarkan teknik purposive sampling sebanyak 3 orang siswa. Analisis hasil penelitian ini menunjukkan bahwa kemampuan pemecahan masalah matematis ditinjau dari minat belajar siswa: (1) Minat belajar dari ketiga siswa semuanya tergolong tinggi dengan kemampuan pemecahan masalah setiap siswa beragam pada kategori tinggi, sangat tinggi dan sedang (2) Tingkat minat belajar siswa cenderung mempengaruhi tingkat kemampuan pemevahan masalah siswa. Siswa pertama yang memiliki minat belajar tingkat kategori tinggi cenderung memiliki kemampuan pemecahan masalah matematis tinggi. Siswa kedua yang memiliki minat belajar tingkat kategori tinggi cenderung memiliki kemampuan pemecahan masalah matematis sangat tinggi dan Siswa ketiga yang memiliki minat belajar tingkat kategori tinggi cenderung memiliki kemampuan pemecahan masalah matematis sedang
Students' mathematical abilities in statistics
Authors: Maulana Dikri
Published: September 2024

Basically, every student must master mathematics taught in school because mathematics is a science that is always used in everyday life, but in fact, many students think that mathematics is a difficult subject that makes them feel dizzy in learning mathematics. The purpose of this study was to analyze students' mathematical communication skills in statistics material. The subjects used were junior high school class IX students who had studied statistics material with a sample of two people. The method used is a descriptive qualitative research method, and the instruments used consist of a test instrument for mathematical communication skills, interviews, and field notes. Based on the results of the research conducted, it shows that most of them have mastered mathematical communication skills and are included in the good criteria with a percentage of 79.85%.
Pada dasarnya setiap siswa harus menguasai matematika yang diajarkan di sekolah karena matematika adalah ilmu yang selalu di pakai dalam kehidupan sehari-hari, tapi pada kenyataannya banyak siswa berpendapat bahwa matematika adalah pelajaran yang sulit sehingga membuat mereka merasa pusing dalam mempelajari matematika. Tujuan dari penelitian ini adalah untuk menganalisis kemampuan komunikasi matematis siswa pada materi statistika. Subjek yang digunakan yaitu siswa SMP kelas IX yang sudah mempelajari materi statistika dengan sampel sebanyak dua orang. Metode yang digunakan adalah metode penelitian deskriptif kualitatif dan instrumen yang digunakan teridiri atas instrumen tes kemampuan komunikasi matematis, wawancara dan catatan lapangan. Berdasarkan hasil penelitian yang dilakukan menunjukkan bahwa kemampuan komunikasi matematis sebagian besar mereka sudah menguasai kemampuan komunikasi matematis dan termasuk ke dalam kriteria baik dengan persentase sebesar 79.85%.
Peningkatan motivasi belajar siswa dalam pembelajaran berbasis masalah dengan asesmen team game tournament
Authors: Darojat Latifah
Published: September 2024

This research aims to determine the increase in mathematics learning motivation of class XII students at SMA Al Islam 1 Surakarta through problem-based learning with Team Game Tournament assessments.  This research is classroom action research. This research was carried out in 2 cycles using data collection methods in the form of motivational questionnaires. Motivational questionnaires were given to research subjects at the pre-cycle, cycle I, and cycle II stages. The analysis technique used in this research is the descriptive qualitative data analysis technique. From the research results, information was obtained that at the pre-cycle stage, students' learning motivation in class XII was still not optimal. Then in cycle I, where the teacher had implemented problem-based learning with the Team Game Tournament assessment, information was obtained that students' learning motivation began to increase. In cycle II, it was also found that there was an increase in student learning motivation. Thus, it can be concluded that implementing problem-based learning with team game tournament assessments can increase student motivation in learning mathematics.
Tujuan dari penelitian ini adalah untuk mengetahui peningkatan motivasi belajar matematika siswa kelas XII di SMA Al Islam 1 Surakarta melalui pembelajaran berbasis masalah dengan asesmen Team Game Tournament. Penelitian ini merupakan penelitian tindakan kelas. Penelitian ini dilaksanakan dalam 2 siklus dengan menggunakan metode pengumpulan data berupa angket motivasi. Angket motivasi diberikan kepada subyek penelitian pada tahap pra siklus, siklus I, dan siklus II. Teknik analisis yang digunakan dalam penelitian ini adalah teknik analisis data kualitatif deskriptif. Dari hasil penelitian diperoleh informasi bahwa pada tahap pra siklus, motivasi belajar siswa di kelas XII masih belum maksimal. Kemudian pada siklus I, dimana guru telah menerapkan pembelajaran berbasis masalah dengan asesmen Team Game Tournament, diperoleh informasi bahwa motivasi belajar siswa mulai meningkat. Pada siklus II, juga ditemukan adanya peningkatan motivasi belajar siswa. Dengan demikian, dapat disimpulkan bahwa pengimplementasian pembelajaran berbasis masalah dengan asesmen Team Game Tournament dapat meningkatkan motivasi siswa dalam belajar matematika.
Assessing the phytosociological characteristics of weed complex in okra field under different control strategies
Authors: Ayodele* O. P. , Aluko O. A. , Amosun J. O. , Udemba I. O.
Published: September 2024

Weed diversity is crucial for supporting ecological services, but weed control methods significantly influence weed species dominance and diversity. The present study was conducted in southwestern Nigeria’s rainforest-savanna transitional agroecological zone during the 2017 and 2018 rainy seasons. Different weed management techniques were assessed, including applying cyanide-сontaining cassava effluent (CE@3WAS), pendimethalin (P), and hoe weeding (HW@3WAS), as well as repeated applications of HW and CE (HW@3&5WAS, CE@3&5WAS), and integrated approaches (P + CE@5WAS, P + HW@5WAS, CE@3WAS + HW@5WAS). A control treatment, where the weeds were left unmanaged, was also included. The experiment followed a randomized complete block design with three replications. Weed samples were collected using 25 cm x 25 cm quadrats placed randomly along the plot diagonals. Weed diversity was assessed using the ShannonWiener index and descriptive statistics. Results indicated that the control methods influenced weed species composition. Specifically, the presence of broad-leaf weeds was prominent in the P + HW@5WAS (2017) and P + CE@5WAS (2018) treatments, while grasses dominated in the weedy check (2017) and HW@3WAS (2018), suggesting that these strategies favour specific morphological groups of the weeds. Weed diversity decreased across various management practices, with the rankings in ascending order: CE@3&5WAP, CE@3WAP, P+CE@5WAS, CE@3WAP + HW@5WAP, P + HW@5WAP, Pendimethalin, HW@3WAP, and HW@3&5WAP. These findings underscore the importance of selecting weed management strategies based on weed ecological significance. Integrated weed management emerged as a more ecologically sustainable approach for okra fields compared to sole herbicide application or manual weeding.
The Concept of a Versatile Computing Tool Chain for Utilizing the Core Data Set of the Medical Informatics Initiative in the INTERPOLAR Project
Authors: Stäubert Sebastian , Strübing Alexander , Schmidt Florian , Yahiaoui-Doktor Maryam , Reusche Matthias , Meineke Frank , Neumann Daniel , Loeffler Markus
Published: September 2024

Introduction: To support research projects that require medical data from multiple sites is one of the goals of the German Medical Informatics Initiative (MII). The data integration centers (DIC) at university medical centers in Germany provide patient data via FHIR® in compliance with the MII core data set (CDS). Requirements for data protection and other legal bases for processing prefer decentralized processing of the relevant data in the DICs and the subsequent exchange of aggregated results for cross-site evaluation. Methods: Requirements from clinical experts were obtained in the context of the MII use case INTERPOLAR. A software architecture was then developed, modeled using 3LGM2, finally implemented and published in a github repository. Results: With the CDS tool chain, we have created software components for decentralized processing on the basis of the MII CDS. The CDS tool chain requires access to a local FHIR endpoint and then transfers the data to an SQL database. This is accessed by the DataProcessor component, which performs calculations with the help of rules (input repo) and writes the results back to the database. The CDS tool chain also has a frontend module (REDCap), which is used to display the output data and calculated results, and allows verification, evaluation, comments and other responses. This feedback is also persisted in the database and is available for further use, analysis or data sharing in the future. Discussion: Other solutions are conceivable. Our solution utilizes the advantages of an SQL database. This enables flexible and direct processing of the stored data using established analysis methods. Due to the modularization, adjustments can be made so that it can be used in other projects. We are planning further developments to support pseudonymization and data sharing. Initial experience is being gathered. An evaluation is pending and planned.
Unlocking Real-World Health Data from Non-University Locations Through Effective Provision of Tools and Knowledge
Authors: Bartos Martin , Nesterow Igor , Mulitza Marco , Rösler Derk , Irshaid Samir , Hoffmann Katja , Klengel Cigdem , Girschner Christian , Gruhl Mirko , Seim Anne , Sedlmayr Martin , Weidner Jens , Nüßler Frank
Published: September 2024

Introduction: The Medical Informatics Initiative (MII) in Germany has pioneered platforms such as the National Portal for Medical Research Data (FDPG) to enhance the accessibility of data from clinical routine care for research across both university and non-university healthcare settings. This study explores the efficacy of the Medical Informatics Hub in Saxony (MiHUBx) services by integrating Klinikum Chemnitz gGmbH (KC) with the FDPG, leveraging the Fast Healthcare Interoperability Resources Core Data Set of the MII to standardize and harmonize data from disparate source systems. Methods: The employed procedures include deploying installation packages to convert data into FHIR format and utilizing the Research Data Repository for structured data storage and exchange within the clinical infrastructure of KC. Result: Our results demonstrate successful integration, the development of a comprehensive deployment diagram, additionally, it was demonstrated that the non-university site can report clinical data to the FDPG. Discussion: The discussion reflects on the practical application of this integration, highlighting its potential scalability to even smaller healthcare facilities and to pave the way to access to more medical data for research. This exemplary demonstration of the interplay of different tools provides valuable insights into technical and operational challenges, setting a precedent for future expansions and contributing to the democratization of medical data access.
Development, Involvement and Use of an Overarching In-House Registry for Clinical Trials
Authors: Ablaß Torge , Simon Friedrich , Schwitlick Christina , Olbrich Denise , Brandt Kristina , Hohensee Ina , von Bubnoff Nikolas , Baldus Claudia , Ingenerf Josef , Schreiweis Björn , Kock-Schoppenhauer Ann-Kristin
Published: September 2024

Introduction: Conducting clinical studies is an integral part of the clinical research repertoire of university hospitals. A wealth of organizational competences must always be available in a central location and in an up-to-date form for appropriate administration. Information such as the number of ongoing studies, and the number of enrolled participants is required for tasks related to e.g. sponsor quality management and KPIs. A registry for clinical trials can answer these questions and enhance the exchange of information. Methods: Requirements for an in-house registry for clinical trials were defined in a multidisciplinary task force. The requirements included interfaces and key abilities to create customized reports to fulfill the obligation to provide evidence. Results: The study registry is productive since May 2020 and internal interfaces have been implemented to ensure consistency between systems and the documented studies. Manually recorded data is enhanced by interfaces to primary registers. The comprehensive data set in the study register enables the creation of individual queries at any time for a variety of questions. Discussion: The UKSH study register has already demonstrated its usefulness in various applications and several projects. The extensive data set and the modular realization allows many current and future requirements to be met.
The German Central Health Study Hub – A Service to Find and Publish Clinical, Public Health and Epidemiolocal Studies and Associated Documents
Authors: Darms Johannes , Clemens Vera , Gonzalez-Ocanto Marisabel , Brünings-Kuppe Claudia , Cici Selim , Fluck Juliane
Published: September 2024

Introduction: The German Central Health Study Hub is a service that was initially developed at short notice during the COVID-19 pandemic. Since then, it has been expanded in scope, content, active users and functionality. The service is aimed at two main audiences: data provider and data consumers. The former want to share research data from clinical, public health and epidemiological studies and related documents according to the FAIR criteria for research data, and the latter want to find and ultimately reuse relevant research data in the above areas. Methods: The service connects both groups via graphical and programmatic interfaces. A sophisticated information model is employed to describe and publish various research data objects while obeying data protection and fulfilling FAIR requirements. The service is being developed in a demand-driven manner with extensive user interaction. Results: A free-to-use service, built on open-source software (Dataverse, MICA, Keycloak), accessible via a web-browser. In close collaboration with users several features (ranging from collection to group items to combined data capture via API and UI) were created. The adoption of the service increases continuously and results in over 1,970 research data objects in June 2024. Conclusion: The service fills a marked gap and connects both user groups, yet it still needs to be improved in various dimensions (features, content, usage). The impact on the community needs to be further assessed. Despite recent legislative changes (GDNG, EHDS), the system improves the findability of sensitive data, provides a blueprint for similar systems and shows how to create a useful and user-friendly service together with users.
Towards Standardizing Ophthalmic Data for Seamless Interoperability in Eye Care
Authors: Hoffmann Katja , Peng Yuan , Schlosser Tobias , Stolze Gabriel , Langner Holger , Susky Marcel , Meyer Trixy , Ritter Marc , Kowerko Danny , Kakkassery Vinodh , Wolfien Markus , Sedlmayr Martin
Published: September 2024

Introduction: Seamless interoperability of ophthalmic clinical data is beneficial for improving patient care and advancing research through the integration of data from various sources. Such consolidation increases the amount of data available, leading to more robust statistical analyses, and improving the accuracy and reliability of artificial intelligence models. However, the lack of consistent, harmonized data formats and meanings (syntactic and semantic interoperability) poses a significant challenge in sharing ophthalmic data. Methods: The Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR), a standard for the exchange of healthcare data, emerges as a promising solution. To facilitate cross-site data exchange in research, the German Medical Informatics Initiative (MII) has developed a core data set (CDS) based on FHIR. Results: This work investigates the suitability of the MII CDS specifications for exchanging ophthalmic clinical data necessary to train and validate a specific machine learning model designed for predicting visual acuity. In interdisciplinary collaborations, we identified and categorized the required ophthalmic clinical data and explored the possibility of its mapping to FHIR using the MII CDS specifications. Discussion: We found that the current FHIR MII CDS specifications do not completely accommodate the ophthalmic clinical data we investigated, indicating that the creation of an extension module is essential.
Metadata Driven Integration of Clinical Data for Secondary Use in FHIR – A Pilot Study at the UKSH
Authors: Simon Friedrich , Schladetzky Jan , Macke Stefanie , Ablaß Torge , Ingenerf Josef , Kock-Schoppenhauer Ann-Kristin
Published: September 2024

Introduction: The reuse of clinical data from clinical routine is a topic of research within the field of medical informatics under the term secondary use. In order to ensure the correct use and interpretation of data, there is a need for context information of data collection and a general understanding of the data. The use of metadata as an effective method of defining and maintaining context is well-established, particularly in the field of clinical trials. The objectives of this paper is to examine a method for integrating routine clinical data using metadata. Methods: To this end, clinical forms extracted from a hospital information system will be converted into the FHIR format. A particular focus is placed on the consistent use of a metadata repository (MDR). Results: A metadata-based approach using an MDR system was developed to simplify data integration and mapping of structured forms into FHIR resources, while offering many advantages in terms of flexibility and data quality. This facilitated the management and configuration of logic and definitions in one place, enabling the reusability and secondary use of data. Discussion: This work allows the transfer of data elements without loss of detail and simplifies integration with target formats. The approach is adaptable for other ETL processes and eliminates the need for formatting concerns in the target profile.
Development of a SNOMED CT Mapping Process and Tool at a Data Integration Centre – Lessons Learned
Authors: Riedel Andrea , Deppenwiese Noemi , Thiele Lucas , Prokosch Hans-Ulrich , Herzog Annalena
Published: September 2024

Introduction: 16 million German-language free-text laboratory test results are the basis of the daily diagnostic routine of 17 laboratories within the University Hospital Erlangen. As part of the Medical Informatics Initiative, the local data integration centre is responsible for the accessibility of routine care data for medical research. Following the core data set, international interoperability standards such as FHIR and the English-language medical terminology SNOMED CT are used to create harmonised data. To represent each non-numeric laboratory test result within the base module profile ObservationLab, the need for a map and supporting tooling arose. State of the Art: Due to the requirement of a n:n map and a data safety-compliant local instance, publicly available tools (e.g., SNAP2SNOMED) were insufficient. Concept and Implementation: Therefore, we developed (1) an incremental mapping-validation process with different iteration cycles and (2) a customised mapping tool via Microsoft Access. Time, labour, and cost efficiency played a decisive role. First iterations were used to define requirements (e.g., multiple user access). Lessons Learned: The successful process and tool implementation and the described lessons learned (e.g., cheat sheet) will assist other German hospitals in creating local maps for inter-consortia data exchange and research. In the future, qualitative and quantitative analysis results will be published.
Classification of Veterinary Subjects in Medical Literature and Clinical Summaries
Authors: Hiltner Marcel , Gulden Christian , Toddenroth Dennis
Published: September 2024

Introduction: Human and veterinary medicine are practiced separately, but literature databases such as Pubmed include articles from both fields. This impedes supporting clinical decisions with automated information retrieval, because treatment considerations would not ignore the discipline of mixed sources. Here we investigate data-driven methods from computational linguistics for automatically distinguishing between human and veterinary medical texts. Methods: For our experiments, we selected language models after a literature review of benchmark datasets and reported performances. We generated a dataset of around 48,000 samples for binary text classification, specifically designed to differentiate between human medical and veterinary subjects. Using this dataset, we trained and fine-tuned classifiers based on selected transformer-based models as well as support vector machines (SVM). Results: All trained classifiers achieved more than 99% accuracy, even though the transformer-based classifiers moderately outperformed the SVM-based one. Discussion: Such classifiers could be applicable in clinical decision support functions that build on automated information retrieval.
Patient-Reported Experience Measures to Evaluate Digitally Supported Care Processes for Heart Failure: A Scoping Review
Authors: Steiner Bianca ,   iCARE4CVD consortium, Azizi Yalda , Verket Marlo , Tyl Benoit , Zippel-Schultz Bettina
Published: September 2024

Introduction: The integration of Patient-Reported Experience Measures (PREM) alongside traditional clinical outcomes is crucial for improving quality of care. Although PREMs are frequently measured in inpatient treatment settings, they are rarely employed in digitally supported care processes or longitudinal assessment of care pathways. Methods: To gain an overview of PREMs used to cover patients’ experiences with digitally supported care processes in heart failure (HF), a scoping review was conducted in Medline. Results: Out of 538 publications, 29 were identified that focus on PREMs in digitally supported care processes across 9 unspecific and 14 disease-specific groups, with 5 manuscripts focusing on HF. PREMs were mostly assessed using self-developed, study-specific questionnaires lacking standardization and validity. In total, 9 PREM dimensions and 25 sub-dimensions were identified. This included care delivery, privacy, physician-patient relationship, involvement, administration, information, knowledge, technology, and experiences in general. Conclusion: The findings suggest that the relevance of different dimensions assessed depends largely on the type of care rather than the underlying chronic disease.
Inclusive Design Thinking for the Development of Digital Health Applications: A Methodology Review
Authors: Riede Mark , Breitschwerdt Rüdiger , Liebe Jan-David
Published: September 2024

Inclusive Design Thinking (IDT) is an approach that specifically addresses disadvantaged user groups and involves them in the innovation process. In recent years, IDT has emerged as a particularly promising approach for increasing citizen and patient engagement in the development of digital health applications. Although IDT is based on existing frameworks of design thinking and human-centered design approaches, there is still no overview of its methods for digital health solutions. Our aim was to develop such a systematic overview of the methods used, aligned with the design process, and thereby facilitate the practical application of IDT. 44 IDT methods could have been consolidated and assigned to the phases of the IDT process. This work provides the first systematic overview of IDT methods used for Digital Health (DH). Future work could expand on this and, for example, investigate the effectiveness of the methods in more detail.
Automatic Classification of Wound Images Showing Healing Complications: Towards an Optimised Approach for Detecting Maceration
Authors: Dührkoop Eric , Malihi Leila , Erfurt-Berge Cornelia , Heidemann Gunther , Przysucha Mareike , Busch Dorothee , Hübner Ursula
Published: September 2024

This study aims to advance the field of digital wound care by developing and evaluating convolutional neural network (CNN) architectures for the automatic classification of maceration, a significant wound healing complication, in 458 annotated wound images. Detection and classification of maceration can improve patient outcomes. Several CNN models were compared and MobileNetV2 emerged as the top-performing model, achieving the highest accuracy despite having fewer parameters. This finding underscores the importance of considering model complexity relative to dataset size. The study also explored the role of image cropping and the use of Grad-CAM visualizations to understand the decision-making process of the CNN. From a medical perspective, results indicate that employing CNNs for classification of maceration may enhance diagnostic accuracy and reduce the clinicians’ time and effort.
Exploring the Microscopic Maze: The Structure and Function of the Hippocampal Arterial Supply
Authors: Chauhan Pradip , Ratanpara Lalit , Mehra Simmi , Chauhan Bhoomika
Published: September 2024

The Hippocampus is a critical organ for memory storage and processing. The Blood supply of the hippocampus is derived from the branches of the anterior choroidal artery and posterior cerebral arteries. Parts of the hippocampus are identified as a head, body and tail; accordingly, hippocampal arteries are named as anterior short, anterior long, posterior short and posterior long hippocampal arteries. Based on the origin of the hippocampal arteries, five different types of hippocampal blood supply have been identified. The hippocampal head has six microanatomical layers; that include the condensed pyramidal cell layer also. Hippocampal microvascular supply and perfusion depend on the lumen and structure of the arterioles. Hippocampal microvascular density is comparatively lower than the neocortical cerebral areas.
Pelatihan Pemberdayaan Sumber Daya Manusia Home Industri Olahan Carica Bagi Usaha Mikro dan Kecil Masyarakat pada Munggang Wonosobo
Authors: Angga Pratama  , Umi Rusilawati  , Sairin
Published: September 2024

Tujuan dari Kegiatan Pengabdian Kepada Masyarakat adalah untuk melaksanakan salahsatu Tri Darma Perguruan Tinggi.Selain itu diharapkan dengan pengabdian kepada masyarakattersebut keberadaan perguruan tinggi dapat memberikan kontribusi besar kepada pengembangandan penerapan keilmuan kepada masyarakat.Metode yang digunakan pada Pengabdian Kepada Masyarakat ini berupa penyampaianmateri secara verbal dan pembelajaran yang menekankan pada proses berpikir kritis dan analitisterkait keilmuan manajemen sumber daya manusia dan pengembangan sumber daya manusiaKesimpulan dari pengabdian ini adalah karyawan membutuhkan motivasi untukmeningkatkan kinerja sehingga diharapkan pihak CV. Boemi Dieng memperhatikan lagi bentukmotivasi kerja pegawai seperti prestasi, karena apabila pegawai merasa termotivasi dalambekerjanya maka kinerja juga akan lebih baik lagi, dengan cara pimpinan memberikanpenghargaan kepada pegawai yang memiliki kemampuan dan memiliki prestasi. Tingginyamotivasi kerja yang membuat pegawai nyaman dan sigap dalam mengerjakan tugasnya Pimpinanharus mengadakan pelatihan/sosialisasi tentang tugas dan fungsi sebagai karyawan atau pegawaidalam menunjang pelaksanaan tugas dan fungsi kerjanya. Sebagai bahan masukan untuk sejauhmana mengevaluasi pegawai tentang motivasi kerja serta memperhatikan unsur-unsur apa yangmembuat pegawai termotivasi dalam meningkatkan kinerja, sehingga nantinya tidak merugikanperusahaan.Kata Kunci: Pengembangan SDM, Kualitas SDM
Strategi Personal Selling Untuk Meningkatkan Pertumbuhan Yayasan Pondok Pesantren Hudatul Falah Ciseeng-Bogor
Authors: Zelin Ferdias Capriati  , Aris Ariyanto  , Ivantan
Published: September 2024

Tujuan dari program ini untuk memberikan penyuluhan dan solusi berdasarkan permasalahanyang ada dilapangan, serta memikirkan strategi yang efektif guna meningkatkan daya tarikmasyarakat khususnya pelajar menjadi santri pada Yayasan Pondok Pesantren. Metode yangdigunakan adalah metode penjelasan, sharing, tanya jawab, diskusi dan praktek. Pada metodepenjelasan, setiap instruktur menyampaikan materi terkait dan membuat tampilan visual berupaslide power point yang ditampilkan ke layar dengan alat LCD proyektor. Hasil kegiatan berjalandengan baik. Para guru yang mengikut kegiatan mengikuti dengan seksama sehinggamenciptakan diskusi yang dua arah. Diharapkan pelatihan mengenai strategi personal sellingmemberikan pengetahuan baru bagi pengurus Yayasan Pondok Pesantren Hudatul FalahCiseeng Bogor dalam melakukan pengembangan pondok pesantren khususnya padapertambahan santri.Kata Kunci: Personal Selling dan Pondok Pesantren