bluuebunny/crossref_metadata_2025 huggingface dataset:
Vertiports: Ready for Take-off … And Landing
Authors: Scott Benjamyn I.
Published: November 2022

While aviation has been used in transportation for decades, the use of vertical takeoff and landing (VTOL) aircraft for large-scale, low-cost, green, sustainable, and integrated mobility in populated areas is a new phenomenon. Despite the importance of ground infrastructure for embarkation and disembarkation of passengers, cargo, and mail, questions remain on how these “vertiports” are or should be regulated and how they will relate to existing regulated ground infrastructure such as aerodromes, airports, and heliports. Therefore, several questions arise: what is a vertiport; how do vertiports relate to other aviation infrastructure; what are the legal implications of having different terms; what laws apply to vertiports? This Article seeks to address these questions from a European Union (EU) perspective by looking at the rise of civil VTOL aircraft and the need for vertiports. Following this, the Article analyzes the current and pro-posed legal landscapes in the EU. This analysis shows how vertiports are currently regulated and highlights the steps that still need to be taken. An examination of the different terms that exist and their definitions is also undertaken. This highlights the similarities and differences that exist between the different terms, thus allowing the relevant laws to be appropriately identified and their scope understood. Finally, the Article looks at some of the legal consequences of introducing the term “vertiport” by focusing on specific EU aviation-based regulations. Thus, this shows the real-life implications of the questions posed.
Treatment of diabetic ketoacidosis with subcutaneous regular insulin in a non-ICU setting is effective and economical: A single-center experience
Authors: Ayyavoo Ahila , Ravikulan Abhimati , Palany Raghupathy
Published: November 2022

Background:

The mainstay of treatment for diabetic ketoacidosis (DKA) is the correction of dehydration and hyperglycemia with intravenous fluids and intravenous insulin (IVI). Subcutaneous insulin (SCI) has been tried in a few centers in patients with DKA if the blood pH is >7. In general, IVI is preferred over SCI or intramuscular insulin as its onset is rapid and the dose can be titrated based on patient’s varying blood glucose (BG) levels. However, IVI is associated with higher cost of hospitalizations and resource requirements. Thus, SCI could be an alternative to IVI infusion for DKA to reduce these costs and distress, in children during times of resource constraint such as the COVID-19 pandemic and in other resource-limited settings.

Objective:

The objective of the study was to compare the cost and efficacy of SCI therapy versus IVI infusion in the treatment of DKA.

Materials and methods:

A retrospective and cohort study was conducted among children aged 1–15 years admitted with DKA from 2013 to 2014 and treated with IVI and in 2017 treated with SCI at a tertiary hospital. One cohort was treated with IV infusion of regular insulin in intensive care units (ICU) and another cohort was treated with SC regular insulin in pediatric general wards. The main outcomes measured were the overall cost of hospitalization and hours to improvement in the child’s health. The data were analyzed with independent samples t-test with SPSS software.

Results:

Forty-eight patients admitted with 50 episodes of DKA were analyzed. Baseline characteristics of the two groups were similar in age, sex, BG, serum sodium, and HbA1C levels. The proportion of girls to boys was 13:8 (IV insulin group) and 20:9 (SC insulin group); the daily dose of insulin on day 1 of treatment was 1.2:1 unit/kg/day in IVI: SCI groups. The lowest recorded pH was 6.822 (range 6.822–7.154) and 6.831(range 6.831–7.292) in the IVI and SCI groups. The mean pH was 7.00 ± 0.10 and 7.1 ± 0.12, respectively, in IVI and SCI groups (P = 0.02). Episodes of DKA treated with IVI and SCI groups were 21 and 29, respectively. 23% of patients had severe DKA, 52% had moderate DKA, and 25% had mild DKA. The mean time for improvement in the IVI group was 34.95 ± 14.05 h and 17.23 ± 9.85 h in the SCI group (P = 0.001), respectively. The average cost of hospitalization was Rs. 53712 ± 18813 for IVI therapy and Rs. 14369 ± 5768 for SCI (P = 0.000). There were no major complications in the SCI group compared to the IVI group.

Conclusion:

DKA was managed effectively in general wards with SCI therapy with pH not being a limiting factor. Earlier studies have used SCI only in patients with a pH of >7. Therapy with SCI was cost-effective and would be useful in resource-poor settings.
Allan-Herndon-Dudley syndrome: Report of a novel pathogenic variant in MCT8 gene
Authors: Kulkarni Abhishek , Desai Devika Ramakant , Kothari Pankhuri Nakul
Published: November 2022

X-linked MCT8 mutations cause Allan-Herndon-Dudley syndrome (AHDS) characterized by severe developmental delay and specific thyroid function abnormality. The report describes a 1 year-old boy with severe developmental delay, truncal hypotonia, quadriparesis (spastic), dystonia, and thyroid function abnormality (high free T3, low reverse T3, low free T4, and normal TSH) suggesting a form of impaired thyroid hormone sensitivity, namely, AHDS. WES analysis yielded novel hemizygous single-base pair duplication in exon 1 of MCT8 gene, validated by Sanger sequencing. MRI revealed generalized demyelination with poor gray and white matter differentiation and loss of brain volume. Indirect markers revealed thyrotoxicosis in some peripheral tissues. Having high index of suspicion for this rare disorder and plausible benefit of inclusion of free T3 assay in initial evaluation of infants and children with idiopathic developmental delay are emphasized. Amelioration of thyrotoxic features with tri-iodothyroacetic acid likely benefits patients at all ages. Neurodevelopmental improvement has been observed in those who received tri-iodoacetic acid early, which is being currently investigated.
Sémiotique de la photographie
Authors: Basso Fossali Pierluigi , Dondero Maria Giulia
Published: November 2022

« Pierluigi Basso et Maria Giulia Dondero nous proposent une plongée sans concession dans un univers éminemment problématique : Sémiotique de la photographie peut être lu à la fois comme un livre de référence sur un domaine de pratiques et d’objets culturels propre au XXe siècle, et comme un exemple de problématisation théorique et méthodologique. Les spécialistes de la photographie y trouveront toutes les références nécessaires, et les sémioticiens y verront à l’œuvre une exceptionnelle entreprise de questionnement. » Extrait de la préface de Jacques FONTANILLE.
To Play or Not to Play. Corrosion of Historic Brass Instruments
Authors: Skamletz Martin
Published: November 2022

Der vorliegende Band versammelt Ergebnisse eines vom SNF unterstützten,
multidisziplinären Forschungsprojekts zu Korrosion im Innern von historischen
Blechblasinstrumenten und ergänzt sie mit weiteren Beiträgen zum Thema der Konservierung
insbesondere im Museumsbetrieb. Musikwissenschaftliche und organologische
Fragestellungen treffen dabei auf chemische und physikalische Analysen, die wiederum im
Hinblick auf ihre Handhabbarkeit und praktische Relevanz im Museumskontext betrachtet
werden.
Endoscopy as an Investigative Method
Authors: Ledergerber Martin
Published: November 2022

Endoscopy is a non-destructive, straightforward, optical investigative method that
permits one to examine changes inside brass instruments. This article describes the
results of repeated endoscopic examinations of sixteen period brass instruments that
were played regularly over several months. Moreover, endoscopic assessments were made of
the effectiveness of preventive conservation measures that had been developed by
researchers of the project and applied by musicians while the instruments were in
use.
MEDIDAS DE EQUILIBRIO ACTUARIAL EN LA SEGURIDAD SOCIAL ESPAÑOLA: REGRESO AL PASADO
Authors: de la Peña Esteban Joseba Iñaki , Fernández-Ramos Cristina , Herrera Ana T. , Peña-Miguel Noemí
Published: November 2022

Abstract In many national social security systems several measures of actuarial balance have been taken. Nevertheless, the future demographic situation of a national social security is known by enough precedence. So, those measures of actuarial balance could have been applied enough years ago. In this paper, several measures of actuarial balance are applied on the Spanish social security under the values of a real economy for the last years. This is a form to quantify the hypothetical effect in the beneficiaries. Of the comparison with the current situation it is possible to realize the true efficiency and the economic and social consequences that they could have been adopted. Keywords: actuarial balance, social security, pensions, social welfare. Resumen En muchos sistemas de seguridad social nacionales se han tomado medidas de ajuste ante problemas financieros y económicos. Sin embargo, la situación demográfica futura y económica de un sistema nacional de previsión se conoce con bastante anterioridad, por lo que las medidas tomadas en las reformas, se podían haber aplicado hace bastantes años. En el presente trabajo se aplican para un pasado cercano medidas de equilibrio sobre la seguridad social española bajo los valores de una economía real para los últimos años y así cuantificar su efecto hipotético en los pensionistas. De la comparación con la situación actual se puede constatar su eficacia así como las consecuencias económicas y sociales de las diferentes medidas que se hubiesen podido adoptar. Palabras Clave: equilibrio actuarial, seguridad social, pensiones, previsión social.
ANÁLISIS DE LA DEPENDENCIA ESPACIAL ENTRE ÍNDICES BURSÁTILES
Authors: Acuña Carlos , Bolance Catalina , Torra Salvador
Published: November 2022

Abstract We discuss the benefits of using neighbourhood relations between stock markets based on time criteria, such as the time differences between countries and the simultaneous opening hours between markets, when they are compared with the distance in kilometres of their capitals. The objective is to find clusters between neighbouring stock indices. We used the Moran I statistic in order to analyse the spatial dependencies between indices. The results showed that the criterion based on simultaneous opening hours provide more relationships between neighbourhood markets. In addition, particularly between European markets, neighbourly relations are more intense during the 2008 financial crisis. Keywords: distance, similarity, spatial dependence, stock returns, financial markets. Resumen Analizamos las ventajas de utilizar relaciones de vecindad entre mercados bursátiles basadas en criterios horarios, como son las diferencias horarias entre países y las horas de apertura simultáneas entre mercados, si se comparan con la relación basada en distancia en kilómetros entre capitales. El objetivo es encontrar agrupaciones entre índices bursátiles vecinos. Utilizamos el estadístico de I de Moran para detectar dependencias espaciales entre índices. Los resultados muestran que el criterio basado en las horas de apertura simultáneas de los mercados proporciona mayores relaciones de vecindad. Además, entre los mercados europeos dichas relaciones son más intensas durante la crisis financiera. Palabras Clave: distancia, similitud, dependencia espacial, rendimientos bursátiles, mercados financieros
Scoring and prediction of early retirement using machine learning techniques: application to private pension plans
Authors: Rocha Salazar Jose de Jesús , Rocha Salazar Jose de Jesus , Boado-Penas María del Carmen
Published: November 2022

Artificial intelligence techniques have become very popular in public and private organizations since they allow a more accurate decision-making process. Private insurance companies have ventured into this field by implementing algorithms that allow a better understanding of available data. The knowledge of retirement decisions allows the insurance companies to detect early retirement at a given time so that they have the adequate budgetary provision in place. In this paper, machine learning algorithms and data from private pension plans are used to predict whether a person retires before or after 65 years old in function of both individual characteristics and macroeconomic factors.
Implicaciones éticas de los life settlements y los viatical settlements
Authors: de Andrés-Sanchez  , de Andrés-Sánchez Jorge
Published: November 2022

En este trabajo analizamos las implicaciones éticas y morales de las transacciones conocidas como life settlements y viatical settlements. Son transacciones muy habituales en el mercado de seguros de EEUU, pero bastante desconocidas en Europa e inexistentes en España. Los mercados de seguros de vida tienen, por su naturaleza, un alto grado de asimetría informativa y riesgo moral y, además, estos acuerdos se hacen generalmente en una situación de fragilidad en la salud y financiera del asegurado. Estas cuestiones generan diversos dilemas éticos y morales sobre los que reflexionamos en este trabajo.
Total Synthesis of Pargamicin A
Authors: Elbatrawi Yassin , Gerrein Taylor , Anwar Avraz , Makwana Kamlesh , Degen David , Ebright Richard , Del Valle Juan
Published: November 2022

We report the total synthesis and configurational assignment of pargamicin A, a highly oxidized non-ribosomal peptide that potently inhibits the growth of drug-resistant bacteria. Our synthetic approach relies on late-stage piperazine ring formation and careful selection of condensation reagents to assemble the densely substituted hexapeptide backbone. This work enables the synthesis of pargamicin congeners for the development of structure-activity relationships and informs strategies to access other sterically congested piperazic acid-containing natural products.
Understanding the Role of Ring Strain in beta-Alkyl Migration at Mg and Zn Centres
Authors: Parr Joseph , Phanopoulos Andreas , Vickneswaran Aaranjah , Crimmin Mark
Published: November 2022

The activation of C–C sigma-bonds within strained three- and four-membered hydrocarbons at electrophilic Mg and Zn centres is reported. This was achieved in a two-step process involving (i) hydrometallation of a methylidene cycloalkane followed by (ii) intramolecular C–C bond activation. While hydrometallation of methylidene cyclopropane, cyclobutane, cyclopentane and cyclohexane occurs for both Mg and Zn reagents, the C–C bond activation step is sensitive to ring size. For Mg, both cyclopropane and cyclobutane rings participate in C–C bond activation. For Zn, only the smallest cyclopropane ring reacts. These findings were used to expand the scope of catalytic hydrosilylation of C–C -bonds to include cyclobutane rings. The mechanism of C–C sigma-bond activation was investigated through kinetic analysis (Eyring), spectroscopic observation of intermediates, and a comprehensive series of DFT calculations, including Activation Strain Analysis. Based on our current understanding, C–C bond activation is proposed to occur by beta-alkyl migration step. beta-Alkyl migration is more facile for more strained rings and occurs with lower barriers for Mg compared to Zn. Relief of ring strain is a key factor in determining the thermodynamics of C–C bond activation, but not in stabilising the transition state for beta-Alkyl migration. Rather we ascribe the differences in reactivity to the stabilising interaction between the metal centre and the hydrocarbon ring-system, with the smaller rings and more electropositive metal (Mg) leading to a less destabilisation interaction energy as the transition state is approached. Our findings represent the first example of C–C bond activation at Zn and provide detailed new insight into the factors at play in beta-alkyl migration at main group centres.
Epistemic and ethical considerations in the direct-to-consumer health and ancestry genetic testing process
Authors: Huerne Katherine
Published: November 2022

Background: Direct-to-consumer genetic testing (DTC-GT) is a popular and fast-growing field within the healthcare industry. Consumers often pursue DTC-GT without a clear understanding of its epistemic and medical limitations. This report will present the current state of DTC-GT technology, and highlight the ethical, legal and social issues of DTC-GT.
Methods: Quantitative methods such as systematic reviews were used to evaluate the field of DTC-GT. Experimental data was taken from randomized control trials and case studies of 23andMe. Qualitative methods such as newspaper articles and surveys were also used. Relevant policies and regulatory information were analyzed in the context of 23andMe. Broader ethical issues are analyzed from the social disability model and feminist ethics frameworks.
Results: Several aspects of direct-to-consumer genetic testing are outlined: (i) regulatory and legal distinctions of DTC-GT that separate its use from conventional genetic testing, (ii) epistemic issues of the genetic testing process within the direct-to-consumer context, and (iii) ethical considerations of DTC-GT in regard to genetic health and genetic ancestry.
Conclusion: This report does not take a position for or against the use of DTC-GT; rather, it highlights the key ethical issues often missed in the DTC-GT process. There is no perfect method for understanding genetic health and race. DTC-GT offer consumers the ease and power of taking genetic data ‘in their own hands’, at the cost of exacerbating geneticization and race essentialism. Until further work is done to address the epistemic, regulatory and legal issues, ethical implications of DTC-GT usage will continue to exist.
Comparative Evaluation of Chemerin and Visfatin Levels in Saliva of Patients with Chronic Periodontitis and Type-2 Diabetes Mellitus: A Clinicobiochemical Study
Authors: Sree* Mythri , Rao Rachana , SJ Manoranjan , V Ranganath
Published: November 2022

Background and Aims Chronic periodontitis and diabetes are common chronic diseases which shows bidirectional relationship. There is an increased expression of immune response mediators between diseased and healthy controls and may represent a possible explanation for the association between the two diseases. The study aimed to i detect biomarkers chemerin and visfatin in saliva ii assess their levels in patients with and without chronic periodontitis and type 2 diabetes mellitus.Methods A total of 80 subjects were randomly selected and divided into four groups 20 in each. Periodontal status was examined using the Plaque index PI Gingival index GI Probing pocket depth PPD and Clinical attachment level CAL. Fasting blood sugar FBS levels and HbA1c assay were assessed to establish the diabetic status of the individual. Unstimulated salivary samples were collected for chemerin and visfatin assessment using ELISA. Stepwise multiple linear regression analysis was performed to predict the salivary chemerin and visfatin levels using clinical amp diagnostic parameters in each group. The level of significance p-value was set at p lt0.05.Results Periodontal clinical parameters PI GI PPD CAL were recorded higher in test groups when compared to control group p lt0.05. Salivary chemerin and visfatin levels were highest in group 4 followed by group 2 group 3 and group 1.Conclusion Human salivary chemerin and visfatin can be considered as potential biomarkers for inflammatory periodontal disease and type 2 diabetes mellitus. Prospective studies with larger sample size and other populations are warranted to explore the diagnostic applicability of these markers.nbsp
The concept of distributed leadership in education: diversity and evolution of approaches
Authors: Mandragelia V.
Published: November 2022

The purpose of the article is to analyze the theoretical and practical aspects, methodological approaches associated with the concept of distributed leadership (DL). This notion is very complex, contradictory, and there are many opinions regarding its essence, content, and genesis in the history of science, key components. Recent integrated educational innovations, the dynamic development of digital technologies, and the constraints associated with the pandemic call for a stronger teamwork of faculty and students and a rethinking of the overall concept of leadership. Leadership roles are many and varied, from facilitation, collaboration and influence, as well as carrying other aspects such as power and prestige. It should be added that the concept of "distributed leadership" is closely related to related concepts, such as “shared leadership” (SL), “collective leadership”, “collaborative leadership”, “co-leadership”, “emergent leadership”, ”dispersed’ leadership” and so on. Distributed leadership has many different aspects that are difficult to clearly define, but the vast majority of experts agree that This is the transfer of attention from the specifics of leadership styles, which are determined by the qualitative psychological and behavioral characteristics of formal and informal leaders, to a broader and systemic context, a distinctive feature of which is teamwork and collective creativity. The article analyzes different approaches to distributed leadership and emphasizes the need for its practical application in the field of education. DL has a huge impact on the qualitative improvement of the organizational culture of the team, the development of optimal solutions to complex problems, contributes to the preparation of proactive, creative individuals. This is very important in the field of education in a pandemic, when the role of digital technologies and the creativity of teachers is significantly increasing. It should also be emphasized that there is a close link between DL and the effectiveness of teachers.
Online assessment of learning outcomes: the experience of Poland
Authors: Wornalkiewicz W. , Diachenko O. , Haranzha O.
Published: November 2022

The epidemiological situation and periodic restrictions imposed in Poland in 2020-2021 forced universities to quickly transform off-line learning into distance one. For this reason, the offered standard e-learning platforms and/or the created own implemented internet access applications were used. Full-fledged distance learning at a university has also become possible thanks to recording the students’ grades in their electronic indexes. The article analyses the process of organizing the assessment of students' knowledge in Polish universities. The situation of online assessment was considered on the example of the Faculty of Economics and Pedagogy, the Academy of Management and Administration in Opole. The place of the lecturer's thematic blog in the preparation of students' final works was also analysed. The authors argue that the experience of a Polish university can be used in organizing the assessment of students' learning outcomes in Ukrainian universities and secondary schools.
Haar Wavelet for Numeric Solution of Rlc Circuit Differential Equations
Authors: Abdulghani Batool Abdulsatar , Khorsheed Jeeman Ahmed , Mustafa Firas Mahmood , Al-sulaifanie Ahmed Khorsheed
Published: November 2022

The wavelet transformation is a mathematical method developed over the past decades to be adapted for applications in the fields of science and engineering. The wavelet transform can be applied in the field of numerical analysis to solve the differential equation. This paper is concerned with applying Haar wavelet methods to solve an ordinary differential equation for an RLC series circuit with a known initial state. The matrix construction calculations are proposed in a simple way. Three numerical mathematical examples are shown that include second-order differential equations with variable and constant coefficients. The results showed that the proposed method is quite reasonable while comparing the solution of second order systems by Haar wavelet method with the exact solution in the context of serial RLC circuit. Moreover, the use of Haar waves is found to be simple, accurate, with flexible and appropriate arithmetic computational costs.
Binoh Pottery MSME marketing expansion through digital marketing strategy
Authors: Darma I Made Riski Aditya , Anggaria Wardani Kadek Devi Kalfika , Gama Adie Wahyudi Oktavia
Published: November 2022

Intense competition and the digital ecosystem have hampered the growth of Binoh's typical pottery MSMEs. Based on problems, the Binoh Pottery MSMEs in Ubung Kaja Village can reach the digital world and a broader market through training and the application of digital-based business. Thus, MSME entrepreneurs can market and promote products through digital channels. Through a series of planned activities, this community service activity aims to provide education on the application of digital business to the Pottery MSMEs in Binoh Village. By using the Participatory Rural Appraisal (PRA) method, the activities are divided into four major stages, namely initial initiation and planning, implementation, supervision, and evaluation. Based on the results of observations and evaluations, it is known that the response of MSMEs actors is very positive to the education provided. MSMEs actors view digital marketing as having an important role to help their businesses survive. It is hoped that in the next stage the government will take an active role in developing Binoh typical pottery MSMEs, Ubung Kaja Village. Not only as a form of effort to move the people's economic sector but also as an effort to maintain pottery as traditional Balinese art.
Creating interactive animation media training as a digital literacy for junior high school teachers
Authors: Lukma Hazairin Nikmatul , Nurjanah Nurjanah , Lestanti Sri
Published: November 2022

The COVID-19 pandemic carried an impact on the world of education. As a policy, an online learning system is carried out, where digital literacy has an important role. Digital literacy skills for a teacher are being able to present interesting learning media. Learning media which is the best alternative is interactive multimedia, which can increase students' learning motivation. Teaching and learning activities in SMP Aswaja are dominated by the conventional method. It is still dominated by lectures and has not used varied learning media, especially the use of digital learning media. To improve the teachers’ understanding and skills in this regard, workshops and training activities for Aswaja Junior High School teachers were carried out which were attended by 27 teachers. The training activities were divided into pre-test, digital literacy and digital learning media materials, training for making digital learning media, and post-test. The average value of the pre-test is 73.33, while the average value of the post-test is 86.3. Paired Sample T-Test analysis showed that there was a significant difference between the pre-test and post-test. Thus the training activities were able to improve understanding and skills in making digital learning media for teachers of SMP Aswaja Kunir Wonodadi.
PRODUCTION OF REACTIVE OXYGEN SPECIES UNDER THE ACTION OF UV-B RADIATION ON YEAST CELLS
Authors: Kocharli N. , Hummatova S.
Published: November 2022

The present investigation is devoted to the study of the effect of ultraviolet-B (UV-B) radiation on the survival and production of reactive oxygen species in yeast cells. It has been determined that under the action of UV-B radiation on cells, depending on its dose, the rate of oxidation of the dye 2',7'-dichlorodihydrofluorescein diacetate (H2DCF•DA) increases and a high intensity of DCF fluorescence is observed. When cells are modified with ascorbic acid before irradiation, the rate of H2DCF oxidation and the intensity of DCF fluorescence decreases. The survival rate of modified cells is increased. Ascorbic acid reduces the amount of ROS in the suspension of irradiated cells. At high doses (4.5-10 erg/mm2) of irradiation, the antioxidant effect of ascorbic acid in yeast cells is negligible. The concentration of 2-4 dinitrophenol (DNF) 10-7 M was determined as a protector, in which the substance potentially contributes to the manifestation of the effect of "soft uncoupling" in cells and, under the influence of UV-B radiation on yeast cells, helps to reduce the production of reactive oxygen species and an increase in survival. High concentrations (10–3M–10–5 M) of DNP adversely affect the survival of yeast cells and ROS production. So, it can be concluded that under the action of UV-B rays on yeast cells, antioxidants can possibly participate in the regulation of redox homeostasis.
STRUCTURAL PECULIARITIES OF DNA-DPS CLUSTERS AT DIFFERENT CONCENTRATIONS OF 4-HEXYLRESORCINOL
Authors: Tereshkina K. , Loiko N. , Tereshkin E. , Kovalenko V. , Generalova A. , Krupyanskii Y.
Published: November 2022

The formation of complexes and crystals of bacterial nucleoid DNA inside bacterial cells in response to adverse external influences is of great interest both in biophysics and structural biology, and in various fields of industry. The main role in the condensation and crystallization of DNA in bacteria under stressful conditions (starvation, temperature, oxidative, and other types of stress) is played by DNA-binding proteins DPS. In this work, the dynamic behavior and structure of Escherichia coli DPS protein complexes in solution with short-chain DNA (25 base pairs) are studied using classical molecular dynamics in the all-atom approximation with a change in the concentration of the phenolic lipid 4-hexylresorcinol, which is a chemical analog of bacterial anabiosis inducers. The effect of changing the concentration of

4-hexylresorcinol from 0 to 50, 100 and 500 molecules on the DNA-DPS complex is being studied. By searching for the linear interaction energy, data were obtained on the free energies of DNA-protein binding without and in the presence of 4-hexylresorcinol. It has been shown that high concentrations of

4-hexylresorcinol promote the formation of DNA complexes with DPS. To identify the features of the dynamic behavior of DNA and protein, the principal component analysis was carried out. The spatial and energy characteristics of the complexes was obtained.
STRUCTURE OF SILK FIBROIN NANOPARTICLES: CHARACTERIZATION OF HYDROPHOBIC PATCHES
Authors: Mammedzade A. , Mammadova Ay. , Gasymov O.
Published: November 2022

Nanoparticles are extensively used in various areas of industry. Among different nanoparticles, protein nanoparticles complexed with a wide range of drugs have a great potential for biomedical applications. Silk fibroin exhibits good biocompatibility properties and, therefore, is a good raw material for a wide variety of applications. In this study, structure and hydrophobic patch formation were studied in nanoparticles fabricated from silk fibroin. Far-UV circular dichroism spectroscopy and birefringence observed in a polarized microscope with Congo red staining indicate that fibroin nanoparticles are composed of small amyloid domains. Steady-state and time-resolved fluorescence of ANS revealed two hydrophobic patch formations. Decay-associated spectra of ANS bound to these patches show two species with lifetimes of about 4.2 ns and 14.8 ns. Dissociation constants for ANS complex formation for these patches are 8.3±0.4 M and 5.9±0.3 M, respectively. Acrylamide fluorescence quenching shows that solvent accessibility to native Trp residues is significantly decreased during fibroin nanoparticle formation. Data indicate that nanoparticles fabricated from fibroin are a good candidate for drug delivery applications.
Formulation and Characterization of Poly (Acrylic Acid)- Co-Chitosan Nanoparticles as pH-Thermo-Responsive System to Control Delivery
Authors: Derbali Abir , Bouzid Djallel , Boyron Olivier
Published: November 2022

The present study aims to develop a pH thermosensitive nanocarriers as a drug delivery system to better controll drug release. Nanoparticles was developed by the combination of smart polymers, chitosan and poly(acrylic acid) were chosen as biodegradable vectors to encapsulate and transport the drug. The used method was based on the polymerization of acrylic acid using reticulated chitosan as a template. Analysis of particle size, Zeta potential, and size distribution revealed that most of the resulting nanoparticles had an average diameter less than 100nm, with a high Zeta potentiel about -29.7 mV and a narrow size distribution. In addition, the developed system showed an encapsulation efficiency around 97%. In vitro release test was achieved using different buffer solutions with pH equal to 1.2, 3.6, 4.2, 4.8, 6.8 and 7.4. The release profiles showed that nanoparticles provide drug protection at different pH values. They responded at pH = 3.6 and provided sustained controlled release of up to 62.62% over 8 hours. The results reveal that the prepared nanoparticles can be used as drug delivery carriers. They can improve therapeutic efficiency of the drugs used in the treatment of inflamed tissues where the pH is around 3.6 as in the Crohn disease.
Método da valoração contingente na sub-bacia do Rio Queima Pé, Tangará da Serra, MT, Brasil
Authors: Nascimento Andréia Rezende da C. , Grzebieluckas Cleci , Nascimento Cláudio Ferreira do , Santos Josiane Silva Costa dos , Panhoca Luiz
Published: November 2022

O bom gerenciamento das práticas ambientais em bacias hidrográficas torna-se premente, uma vez que a água tornou fator limitante no desenvolvimento econômico e social, neste contexto a política de Pagamento por Serviços Ambientais hídrico apresenta-se como uma forte aliada na mitigação dos danos em ba- cias hidrográficas. Dessa forma o objetivo da pesquisa foi verificar quanto os consumidores de água estão dispostos a pagar e os proprietários a receber pelos serviços de recuperação e preservação da Sub bacia do rio Queima Pé. A coleta de dados quali-quantitati- vos se deu por meio da aplicação de formulários estruturados com perguntas abertas e fechadas direcionados tanto para moradores urbanos quanto proprietários rurais, o número de pesquisados para a cidade e meio rural foi cem e oito, respectivamente. Através da análise dos formulários foi possível constatar que a maioria (66%) dos pesquisados urbanos estão Dispostos a Pagar algum valor na recuperação e preservação da Sub-bacia do rio Queima Pé. Con- forme as declarações o valor estimado para a Disposição a Pagar foi de R$ 337,82/ha/ano, já a Disposição a Receber dos proprietá- rios, que também foi estimada, consistiu em R$ 751,31/ha/ano. As incongruências entre Disposição a Pagar e Disposição a Receber são observadas na maioria dos estudos, porém subsídios governa- mentais podem ajudar a reduzir as diferenças entre elas.
A importância do controle interno do patrimônio no INSTITUTO FEDERAL DO PARANÁ (IFPR) - CAMPUS CURITIBA
Authors: Custódio Luiz , Angulski Letícia Zanchi , Fernandes Alexandre Machado , Silva Frederico Fonseca da , Stephanello Paulinho René , Leal Cleverson Pereira
Published: November 2022

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Ensino por investigação
Authors: Luns Patrícia Peçanha Roza , Landa Giovanni Guimarães
Published: November 2022

A publicação é o resultado da pesquisa realizada durante o desenvolvimento das atividades de observações participante em uma escola localizada no interior do Estado do Espírito Santo. A pesquisa desenvolvida com os alunos do 4º ano do Ensino Fundamental I da EEMEIEF Georgeta Ferreira de Almeida e tem como escopo orientar e sugerir atividades do ensino por investigação, como uma estratégia metodológica que possibilita estimular a alfabetização científica nas crianças.
Application of optimum level set contour classifier tool for diagnosis of cowpox disease
Authors: V Radhika
Published: November 2022

A new variational definition for infection contamination dynamic shapes that powers the level set capability to be near a marked distance capability, and hence totally dispenses with the need for the exorbitant re- introduction system. Our variational definition comprises an inward energy term that performs the deviation of the level set capability from a marked distance capability, and an outgoing energy term that drives the movement of the underlying level set toward the ideal image highlights, like item boundaries. The subsequent development of the level set capability is the slope stream that limits the general energy practical. The proposed variational level set detailing enjoys three principal approaches over the customary level set plans. Initially, an essentially bigger time step can be utilized for mathematically handling the development, and thus accelerating the tilt development. Second, the level set capability can be instated with general capabilities that are more proficient to develop and simpler to use practically speaking than the broadly utilized marked distance capability. Third, the level set advancement in our plan can be effectively carried out by a basic limited distinction plot and is computationally more proficient. The proposed calculation has been applied to both mimicked and genuine images with promising outcomes.
Effect of agricultural credits on production among smallholder crop farmers in delta state
Authors: Shadrack AKPORAWO  , Peter Otunaruke Emaziye  , Onyeidu Samuel Osemedua
Published: November 2022

The study analysed the effect of agricultural credits on production among smallholder crop farmers in Delta State. Multistage random sampling procedure was adopted for the selection of 210 respondents. Data were collected from primary sources through the use of structured questionnaires and analysed through the use of descriptive and inferential statistical tools. The result showed that most of the respondents were in the age range of 41years to 50 years who were married with secondary school education. Majority were engaged in farming as their primary occupation having mean family size of 8 persons and an average annual income of N250,000. Majority obtained their credit from personal savings and cooperative societies. The major determinants of access to credit in the area were interest rate, type of enterprise, and farm size. The major constraints to obtaining credit were lending policies of credit institutions, lack of knowledge of rules and regulations and provision of collateral security. It is recommended that farmers should be encouraged to form farmers’ cooperative societies to improve access to credits.
Quality Of Service, Tax Understanding, And Tax Sanctions, Effect On Personal Taxpayer Compliance
Authors: Chasanah Maulidatul , Syaiful Syaiful
Published: November 2022

The background in this study is that there is a phenomenon that the realization of state revenues from the tax sector has the largest contribution, which each year experiences ups and downs compared to non-tax revenues. This study aims to test Service Quality, Tax Understanding, and Tax Sanctions, Influence on Individual Taxpayer Compliance. This research uses quantitative methods. The population in this study amounted to 57, while the sampling used the Non Probability Sampling technique using saturated sampling. The reason is because the population size is relatively small. The sample studied by the researcher is 57 taxpayers. The analysis technique uses instrument testing, classical assumption test, and hypothesis testing. For the test tool, the Statistical Package for the Social Sciences (SPSS) is used. The results of this study indicate that the quality of tax services has a positive and significant effect on taxpayer compliance, tax understanding has a positive and significant effect on taxpayer compliance, and tax sanctions have a positive and significant effect on taxpayer compliance.
The Effect of Word of Mouth, Advertising Using Selebgram, and Paid Promote on Purchase Decisions at Ayam Geprek Mang Soetta Gresik
Authors: Putra Dhiemas Arya , Sukaris Sukaris
Published: November 2022

This study aims to determine the effect of Word of Mouth (WOM), advertising using Selebgram, dan Paid Promote to purchasing decision at Ayam Geprek Mang Soetta Gresik. Effective marketing is one of the keys to the success of a business. For this reason, this study was conducted to determine several variables related to marketing and purchasing decisions. This type of research is quantitative research. Using a questionnaire method with incidental sampling techniques and with a sample of 100 consumers of AGMS Gresik. Testing using the SPSS method. The results show that word of mouth (WOM), advertising using Selebgram, and paid promotion have a positive influence on purchasing decisions at Ayam Geprek Mang Soetta Gresik.
New Selection Algorithm on Priority Service for Certification Queue Service Information System in BARISTRAND
Authors: Nugroho Rizky Dwi , Sukmaaji Anjik , Rahmawati Endra , Pujiwidodo Arifin , Sutanto Teguh
Published: November 2022

Queue management for product certification of perishable goods is a major problem faced by the Surabaya Industrial Standardization and Research Institute (BARISTAND). The purpose of this study is to combine the use of the First in first out (FIFO), First Expired First Out (FEFO) and Least Shelf Life First Out (LSFO) methods into an automatic queuing system that can ensure effective service performance in queue management. This research was conducted using qualitative methods with observations to collect data and processes about how the product certification queue process flow at the Surabaya Industrial Standardization and Research Institute (BARISTRAN). The results show that the service only requires an average service completion time of 0.14 products per minute, meaning that every hour it can serve approximately 8.4 products. The conclusion of the research system has succeeded in determining the queue based on the use of the First in first out (FIFO), First Expired First Out (FEFO) and Least Shelf Life First Out (LSFO) methods, and customers can perform the tracking process to find out the certification process for the registered products.
Primo Lanzoni, ovvero l’economia come antitesi all’ambientalismo nel pensiero geografico ottocentesco
Authors: Zanetto Gabriele
Published: November 2022

The evolution of economic geography in the past century has been very complex. The older conception of commercial geography, as mere description of the distribution of economic factors, was substituted by a scientific interpretation of the natural conditions of economic activities. The later school, called environmental determinism, produced an estrangement of economics and economic geography, which was removed only very recently. The paper examines the thought of an Italian geographer, working in Venice around the turn of the century, whose work now appears as a forerunning example of a modern conception of geography, anti-determinist and related to the logic of economics.
Feliciano Benvenuti
Authors: Benvenuti Luigi
Published: November 2022

From an ancient family of Venetian origin, Feliciano Benvenuti was born in Padua in 1916. He graduated in law at the University of Padua with a thesis on The succession between territorial autarchic entities, supervisor Enrico Guicciardi; then he became assistant in the faculty of political science of the same university. During the war he served as a naval officer, and later spent two years in a concentration camp in Germany. In 1951 he obtained the chair in administrative law, and later held the chair of administrative law in the Faculty of Political Sciences of Padua (1951-56), then in the Faculty of Law of the Catholic University of Milan (1956-72) and finally in the Faculty of Economics and Commerce of the Ca’ Foscari University of Venice (1972-83) where he also taught public law. In 1974 he has been elected Rector of Ca’ Foscari, renewed for three mandates. He contributes to the foundation (1959) of the Institute for the Science of Public Administration (ISAP) in Milan, which he directs until 1972; he also acted as president in many cultural and economic entities and institutions. He died in Padua on July 16, 1999.
Lycia Contursi-Lisi Gardani
Authors: Sicchiero Gianluca
Published: November 2022

Lycia Contursi-Lisi Gardani (1920-2004) taught private law until 1990; she graduated in high school focusing on humanities having as a teacher the philosopher Norberto Bobbio. She published texts focused on humanities but her calling was for juridical studies. One of her professors was Francesco Santoro Passelli at the University of Padua and her first monographs in the ’50 awarded her with a lecturing post. She started teaching at Ca’ Foscari when it was still called University Institute for Economic and Trade, where she met Walter Bigiavi. Her publications can be found in the most important Italian legal editorial collections.
The Use of Waterless Alcohol-based Antiseptic for Surgical Skin Preparation in Rhesus Macaques (Macaca mulatta)
Authors: Green Rachel D , Potterton Darlene B , Winterborn Andrew N
Published: November 2022

Ensuring asepsis of the surgical site before surgery is an essential component of safe surgical practices to reduce the incidence of surgical site infections in veterinary medicine. The current accepted method of skin preparation is a multistep process that alternates either a povidone-iodine
or chlorhexidine soap scrub with a 70% alcohol rinse. After cleansing, the site is left to dry before draping. The goal of this study was to assess the effectiveness of a waterless alcohol-based (WAB) antiseptic as part of a 2-step procedure after the soap scrub. WAB antiseptics are commonly
used as a presurgical hand scrub for the surgeon as they evaporate quickly and provide effective antisepsis. Previous studies have examined the WAB antiseptics in small animal surgeries. We tested this approach in large animal surgery. Twenty-four rhesus macaques were divided into 4 groups
that received one of the following treatments: saline and alcohol, iodine-alcohol-iodine, soap scrub/WAB, and chlorhexidine-alcohol-chlorhexidine. The surgical site was swabbed before and after treatment and plated to assess sterility. Overall, no colonies were recovered from skin treated
with WAB antiseptic, establishing it as an effective alternative to the current standard protocol. This method will simplify the current 3-step procedure and reduce animal handling, the use of materials, and the time necessary for surgical preparation.
ANALISIS MANAJEMEN KOMUNIKASI KRISIS PT RAJAWALI NUSANTARA INDONESIA (PERSERO) DALAM MEMPERTAHANKAN CITRA PERUSAHAAN
Authors: Maulida Rizkia Putri
Published: November 2022

PT Rajawali Nusantara Indonesia (Persero) merupakan Badan Usaha Milik Negara (BUMN) yang bergerak pada bidang Agro Industri yang memiliki 11 anak perusahaan satu diantaranya sedang mengalami krisis, krisis yang terjadi akibat adanya Sengketa Lahan Petani Tebu yang disebabkan oleh faktor oknum yang tidak bertanggung jawab.

Tujuan penelitian ini adalah untuk mengetahui penyelesaian krisis pada kasus Sengketa Lahan Petani Tebu dengan menganalisis Manajemen komunikasi krisis meliputi, faktor penyebab terjadinya krisis, bagaimana upaya penanggulangan krisis, penyelesaian krisis. Teori yang digunakan dalam penelitian ini adalah teori Public Relations issue & Crisis Management dari Kriyantono (2015) dalam bukunya meliputi Pra krisis, Krisis, Pasca krisis, Sumber dan jenis krisis, Strategi Komunikasi Krisis: Begin it at once  penelitian ini menggunakan metode Kualitatif dan metode deskriptif dengan teknik pengumpulan data yang dilakukan adalah wawancara, observasi, dan dokumentasi. Wawancara dilakukan melalui zoom meeting dengan satu key informan yaitu executive vice president dan satu informan merupakan Staff Corporate Communications kemuadian menggunakan dua  triangulasi sumber, informan tersebut merupakan orang yang terkait dengan permasalahan kasus tersebut dan juga informan lainnya.

Setelah penelitian ini dilaksanakan ada beberapa hasil penelitian menunjukan Manajemen komunikasi krisis tersebut dibagi menjadi 3 tahap yaitu Pra krisis, Krisis, Pasca krisis, Sumber dan jenis krisis. Pada tahapan persiapan atau Pra krisis dilakukannya analisis seputar issue yang berkembang dan untuk memitigasi krisisnya dilakukan mapping pra krisis korporasi hingga mapping Manajemen risiko, salah satu upaya pencegahan dengan dibuatnya program kemitraa, dan termasuk dilakukannya pelatihan krisis komunikasi pada korporasi, selanjutnya tahapan Krisis menerapkan crisis communications kepada RNI pusat, Pemerintah daerah, dan menjalankan media relations. Kemudian pada tahapan Pasca krisis berfokus pada pemulihan citra yang dilakukan dengan menggunakan strategi communications yang melibatkan dengan publikasi positif terkait dengan corporate actions dan CSR korporasi.

 

Kata kunci : Manajemen komunikasi krisis, Public Relations