bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative proteomic analysis of mitochondrial proteins from maize CMS‐C sterile, maintainer and restorer anthers
Authors: Zhang Huaisheng , Wang Bin , Li Bing , Lin Yanan , Yang Huili , Ding Dong , Xue Yadong , Tang Jihua
Published: May 2020

The maize C system of cytoplasmic male sterility (CMS) and its fertility restoration gene Rf4 have been widely used for maize hybrid production; however, the underlying mechanism is still uncertain. The sterility factor functions in mitochondria, where it interacts directly or indirectly with the restorer. Mitoproteomics can capture all participants involved in CMS and restoration at the organelle level. In the present study, we identified and quantified anther mitochondrial proteins from CMS, maintainer and restorer lines. We obtained 14,528 unique peptides belonging to 3,369 proteins. Comparative analysis of 1840 high‐confidence proteins revealed 68 were differentially accumulated proteins likely involved in CMS or its restoration within mitochondria. These proteins were mainly associated with fatty acid metabolism, amino acid metabolism and protein‐processing pathways. These results suggest that an energy deficiency caused by the sterility factor hinders other proteins or protein complexes required for pollen development through nuclear‐mitochondrial interaction. The restorer factor may boost the energy generation by activating alternative metabolic pathways and by improving the post‐translation processing efficiency of proteins in energy‐producing complexes to restore pollen fertility. Our findings may aid detailed molecular analysis and contribute to a better understanding of maize CMS‐C restoration and sterility.
Nanoparticle contrast agents for X‐ray imaging applications
Authors: Hsu Jessica C. , Nieves Lenitza M. , Betzer Oshra , Sadan Tamar , Noël Peter B. , Popovtzer Rachela , Cormode David P.
Published: May 2020

X‐ray imaging is the most widely used diagnostic imaging method in modern medicine and several advanced forms of this technology have recently emerged. Iodinated molecules and barium sulfate suspensions are clinically approved X‐ray contrast agents and are widely used. However, these existing contrast agents provide limited information, are suboptimal for new X‐ray imaging techniques and are developing safety concerns. Thus, over the past 15 years, there has been a rapid growth in the development of nanoparticles as X‐ray contrast agents. Nanoparticles have several desirable features such as high contrast payloads, the potential for long circulation times, and tunable physicochemical properties. Nanoparticles have also been used in a range of biomedical applications such as disease treatment, targeted imaging, and cell tracking. In this review, we discuss the principles behind X‐ray contrast generation and introduce new types of X‐ray imaging modalities, as well as potential elements and chemical compositions that are suitable for novel contrast agent development. We focus on the progress in nanoparticle X‐ray contrast agents developed to be renally clearable, long circulating, theranostic, targeted, or for cell tracking. We feature agents that are used in conjunction with the newly developed multi‐energy computed tomography and mammographic imaging technologies. Finally, we offer perspectives on current limitations and emerging research topics as well as expectations for the future development of the field.

This article is categorized under:

Diagnostic Tools > in vivo Nanodiagnostics and Imaging

Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Page curve for an evaporating black hole
Authors: Gautason Friðrik Freyr , Schneiderbauer Lukas , Sybesma Watse , Thorlacius Lárus
Published: May 2020

Abstract

A Page curve for an evaporating black hole in asymptotically flat spacetime is computed by adapting the Quantum Ryu-Takayanagi (QRT) proposal to an analytically solvable semi-classical two-dimensional dilaton gravity theory. The Page time is found to be one third of the black hole lifetime, at leading order in semi-classical corrections. A Page curve is also obtained for a semi-classical eternal black hole, where energy loss due to Hawking evaporation is balanced by an incoming energy flux.
Central charges of 2d superconformal defects
Authors: Chalabi Adam , O’Bannon Andy , Robinson Brandon , Sisti Jacopo
Published: May 2020

Abstract

In conformal field theories (CFTs) of dimension d > 3, two-dimensional (2d) conformal defects are characterised in part by central charges defined via the defect’s contribution to the trace anomaly. However, in general for interacting CFTs these central charges are difficult to calculate. For superconformal 2d defects in supersymmetric (SUSY) CFTs (SCFTs), we show how to compute these defect central charges from the SUSY partition function either on S

d
with defect along S
2, or on S
1
× S

d−1 with defect along S
1
× S
1. In the latter case we propose that defect central charges appear in an overall normalisation factor, as part of the SUSY Casimir energy. For 2d half-BPS defects in 4d

$$ \mathcal{N} $$

N

= 2 SCFTs and in the 6d

$$ \mathcal{N} $$

N

= (2, 0) SCFT we obtain novel, exact results for defect central charges using existing results for partition functions computed using SUSY localisation, SUSY indices, and correspondences to 2d Liouville, Toda, and q-deformed Yang-Mills theories. Some of our results for defect central charges agree with those obtained previously via holography, showing that the latter are not just large-N and/or strong- coupling limits, but are exact. Our methods can be straightforwardly extended to other superconformal defects, of various codimension, as we demonstrate for a 4d defect in the 6d

$$ \mathcal{N} $$

N

= (2, 0) SCFT.
Catch crop diversity increases rhizosphere carbon input and soil microbial biomass
Authors: Gentsch Norman , Boy Jens , Batalla Juan Daniel Kennedy , Heuermann Diana , von Wirén Nicolaus , Schweneker Dörte , Feuerstein Ulf , Groß Jonas , Bauer Bernhard , Reinhold-Hurek Barbara , Hurek Thomas , Céspedes Fabricio Camacho , Guggenberger Georg
Published: May 2020

Catch crops increase plant species richness in crop rotations, but are most often grown as pure stands. Here, we investigate the impacts of increasing plant diversity in catch crop rotations on rhizosphere C input and microbial utilization. Mustard (Sinapis alba L.) planted as a single cultivar was compared to diversified catch crop mixtures of four (Mix4) or 12 species (Mix12). We traced the C transfer from shoots to roots towards the soil microbial community and the soil respiration in a 13C pulse labelling field experiment. Net CO2-C uptake from the atmosphere increased by two times in mix 4 and more than three times in mix 12. Higher net ecosystem C production was linked to increasing catch crop diversity and increased belowground transfer rates of recently fixed photoassimilates. The higher rhizosphere C input stimulated the growth and activity of the soil microbiome, which was investigated by phospholipid fatty acid (PLFA) analyses. Total microbial biomass increased from 14 to 22 g m−2 as compared to the fallow and was 18 and 8% higher for mix 12 and mix 4 as compared to mustard. In particular, the fungal and actinobacterial communities profited the most from the higher belowground C input and their biomass increased by 3.4 and 1.3 times as compared to the fallow. The residence time of the 13C pulse, traced in the CO2 flux from the soil environment, increased with plant diversity by up to 1.8 times. The results of this study suggest positive impacts of plant diversity on C cycling by higher atmospheric C uptake, higher transport rates towards the rhizosphere, higher microbial incorporation and prolonged residence time in the soil environment. We conclude that diversified catch crop mixtures improve the efficiency of C cycling in cropping systems and provide a promising tool for sustainable soil management.
Acrophobia and visual height intolerance: advances in epidemiology and mechanisms
Authors: Huppert Doreen , Wuehr Max , Brandt Thomas
Published: May 2020

Historical descriptions of fear at heights date back to Chinese and Roman antiquity. Current definitions distinguish between three different states of responses to height exposure: a physiological height imbalance that results from an impaired visual control of balance, a more or less distressing visual height intolerance, and acrophobia at the severest end of the spectrum. Epidemiological studies revealed a lifetime prevalence of visual height intolerance including acrophobia in 28% of adults (32% in women; 25% in men) and 34% among prepubertal children aged 8–10 years without gender preponderance. Visual height intolerance first occurring in adulthood usually persists throughout life, whereas an early manifestation in childhood usually shows a benign course with spontaneous relief within years. A high comorbidity was found with psychiatric disorders (e.g. anxiety and depressive syndromes) and other vertigo syndromes (e.g. vestibular migraine, Menière’s disease), but not with bilateral vestibulopathy. Neurophysiological analyses of stance, gait, and eye movements revealed an anxious control of postural stability, which entails a co-contraction of anti-gravity muscles that causes a general stiffening of the whole body including the oculomotor apparatus. Visual exploration is preferably reduced to fixation of the horizon. Gait alterations are characterized by a cautious slow walking mode with reduced stride length and increased double support phases. Anxiety is the critical factor in visual height intolerance and acrophobia leading to a motor behavior that resembles an atavistic primitive reflex of feigning death. The magnitude of anxiety and neurophysiological parameters of musculoskeletal stiffening increase with increasing height. They saturate, however, at about 20 m of absolute height above ground for postural symptoms and about 40 m for anxiety (70 m in acrophobic participants). With respect to management, a differentiation should be made between behavioral recommendations for prevention and therapy of the condition. Recommendations for coping strategies target behavioral advices on visual exploration, control of posture and locomotion as well as the role of cognition. Treatment of severely afflicted persons with distressing avoidance behavior mainly relies on behavioral therapy.
Bayesian inference in multivariate spatio-temporal areal models using INLA: analysis of gender-based violence in small areas
Authors: Vicente G. , Goicoa T. , Ugarte M. D.
Published: May 2020

Multivariate models for spatial count data are currently receiving attention in disease mapping to model two or more diseases jointly. They have been thoroughly studied from a theoretical point of view, but their use in practice is still limited because they are computationally expensive and, in general, they are not implemented in standard software to be used routinely. Here, a new multivariate proposal, based on the recently derived M models for spatial data, is developed for spatio-temporal areal data. The model takes account of the correlation between the spatial and temporal patterns of the phenomena being studied, and it also includes spatio-temporal interactions. Though multivariate models have been traditionally fitted using Markov chain Monte Carlo techniques, here we propose to adopt integrated nested Laplace approximations to speed up computations as results obtained using both fitting techniques were nearly identical. The techniques are used to analyse two forms of crimes against women in India. In particular, we focus on the joint analysis of rapes and dowry deaths in Uttar Pradesh, the most populated Indian state, during the years 2001–2014.
Elevated intracranial pressure after head trauma can be suppressed by antisecretory factor—a pilot study
Authors: Gatzinsky Kliment , Johansson Ewa , Jennische Eva , Oshalim Merna , Lange Stefan
Published: May 2020

Background

Control of intracranial pressure (ICP) is a key element in neurointensive care for directing treatment decisions in patients with severe traumatic brain injury (TBI). The anti-inflammatory protein antisecretory factor (AF) has been demonstrated to reduce experimentally induced high ICP in animal models. This report describes the first steps to investigate the uptake, safety, and influence of AF for reduction of elevated ICP in patients with TBI in a clinical setting.

Method

Four patients with severe TBI (Glasgow Coma Scale < 9) that required neurointensive care with ICP monitoring due to signs of refractory intracranial hypertension were investigated. One hundred milliliters of Salovum®, a commercially available egg yolk powder with high contents of AF peptides, was administrated either via nasogastric (patients 1 and 2) or rectal tube (patients 2, 3, and 4) every 8 h for 2 to 3 days as a supplement to the conventional neurointensive care. ICP was registered continuously. Plasma levels of AF were measured by enzyme-linked immunosorbent assay (ELISA) to confirm that Salovum® was absorbed appropriately into the bloodstream.

Results

In the first two patients, we observed that when delivered by the nasogastric route, there was an accumulation of the Salovum® solution in the stomach with difficulties to control ICP due to impaired gastric emptying. Therefore, we tested to administer Salovum® rectally. In the third and fourth patients, who both showed radiological signs of extensive brain edema, ICP could be controlled during the course of rectal administration of Salovum®. The ICP reduction was statistically significant and was accompanied by an increase in blood levels of AF. No adverse events that could be attributed to AF treatment or the rectal approach for Salovum® administration were observed.

Conclusions

The outcomes suggest that AF can act as a suppressor of high ICP induced by traumatic brain edema. Use of AF may offer a new therapeutic option for targeting cerebral edema in clinical practice.
Viable supply chain model: integrating agility, resilience and sustainability perspectives—lessons from and thinking beyond the COVID-19 pandemic
Authors: Ivanov Dmitry
Published: May 2020

Viability is the ability of a supply chain (SC) to maintain itself and survive in a changing environment through a redesign of structures and replanning of performance with long-term impacts. In this paper, we theorize a new notion—the viable supply chain (VSC). In our approach, viability is considered as an underlying SC property spanning three perspectives, i.e., agility, resilience, and sustainability. The principal ideas of the VSC model are adaptable structural SC designs for supply–demand allocations and, most importantly, establishment and control of adaptive mechanisms for transitions between the structural designs. Further, we demonstrate how the VSC components can be categorized across organizational, informational, process-functional, technological, and financial structures. Moreover, our study offers a VSC framework within an SC ecosystem. We discuss the relations between resilience and viability. Through the lens and guidance of dynamic systems theory, we illustrate the VSC model at the technical level. The VSC model can be of value for decision-makers to design SCs that can react adaptively to both positive changes (i.e., the agility angle) and be able to absorb negative disturbances, recover and survive during short-term disruptions and long-term, global shocks with societal and economical transformations (i.e., the resilience and sustainability angles). The VSC model can help firms in guiding their decisions on recovery and re-building of their SCs after global, long-term crises such as the COVID-19 pandemic. We emphasize that resilience is the central perspective in the VSC guaranteeing viability of the SCs of the future. Emerging directions in VSC research are discussed.
Nanoparticle Formation and Behavior in Turbulent Spray Flames Investigated by DNS
Authors: Abdelsamie Abouelmagd , Kruis Frank Einar , Wiggers Hartmut , Thévenin Dominique
Published: May 2020

This work is a first direct numerical simulation of a configuration closely related to the SpraySyn burner (Schneider et al. in Rev Sci Instrum 90:085108, 2019). This burner has been recently developed at the University of Duisburg-Essen to investigate experimentally nanoparticle synthesis in spray flames for a variety of materials. The present simulations are performed for ethanol and titanium tetraisopropoxide as a solvent and precursor, respectively, in order to produce titanium dioxide nanoparticles. In the direct numerical simulations, the complete scenario leading to the production of well-defined nanoparticles is taken into account, including evaporation of the liquid mixture (solvent and precursor) injected as a spray, multi-step kinetics for gas-phase combustion, and finally nanoparticle synthesis. The employed models are described in this article. Additionally, the impact of the inlet velocity of the pilot flame on the nanoparticle synthesis is investigated. It has been found that increasing this speed delays spray flame ignition, decreases nanoparticle concentration, but leads to a narrower size distribution at early stage.
Administrative due process when using automated decision-making in public administration: some notes from a Finnish perspective
Authors: Suksi Markku
Published: May 2020

Various due process provisions designed for use by civil servants in administrative decision-making may become redundant when automated decision-making is taken into use in public administration. Problems with mechanisms of good government, responsibility and liability for automated decisions and the rule of law require attention of the law-maker in adapting legal provisions to this new form of decision-making. Although the general data protection regulation of the European Union is important in acknowledging automated decision-making, most of the legal safeguards within administrative due process have to be provided for by the national law-maker. It is suggested that all countries have a need to review their rules of administrative due process with a view to bringing them up to date regarding the requirements of automated decision-making. In whichever way the legislation is framed, the key issues are that persons who develop the algorithm and the code as well as persons who run or deal with the software within public authorities are aware of the preventive safeguards of legality in the context of automated decision-making, not only of the reactive safeguards constituted by the complaint procedures, and that legal mechanisms exist under which these persons can be held accountable and liable for decisions produced by automated decision-making. It is also argued that only rule-based systems of automatized decision-making are compatible with the rule of law and that there is a general interest in preventing a development into a rule of algorithm.
Non-invasive assessment of central venous pressure in heart failure: a systematic prospective comparison of echocardiography and Swan-Ganz catheter
Authors: Szymczyk Tobias , Sauzet Odile , Paluszkiewicz Lech J. , Costard-Jäckle Angelika , Potratz Max , Rudolph Volker , Gummert Jan F. , Fox Henrik
Published: May 2020

Assessing hemodynamics, especially central venous pressure (CVP), is essential in heart failure (HF). Right heart catheterization (RHC) is the gold-standard, but non-invasive methods are also needed. However, the role of 2-dimensional echocardiography (2DE) remains uncertain, and 3-dimensional echocardiography (3DE) is not always available. This study investigated standardized and breathing-corrected assessment of inferior vena cava (IVC) volume using echocardiography (2DE and 3DE) versus CVP determined invasively using RHC. Sixty consecutive HF patients were included (82% male, age 54 ± 11 years, New York Heart Association class 2.23 ± 0.8, ejection fraction 46 ± 18.4%, brain natriuretic peptide 696.93 ± 773.53 pg/mL). All patients underwent Swan-Ganz RHC followed by 2DE and 3DE, and IVC volume assessment. On 2DE, mean IVC size was 18.3 ± 5.5 mm and 13.8 ± 6 mm in the largest deflection and shortest distention, respectively. Mean CVP from RHC was 9.3 ± 5.3 mmHg. Neither 2DE nor 3DE showed acceptable correlation with invasively measured CVP; IVC volume acquisition showed optimal correlation with RHC CVP (0.64; 95% confidence interval 0.46–0.77), with better correlation when mitral valve early diastole E wave and right ventricular end-diastolic diameter were added. Using a CVP cut-point of 10 mmHg, receiver operating characteristic curve showed true positivity (specificity) of 0.90 and sensitivity of 62% for predicting CVP. A validation study confirmed these findings and verified the high predictive value of IVC volume assessment. Neither 2DE nor 3DE alone can reliably mirror CVP, but IVC volume acquisition using echocardiography allows non-invasive and adequate approximation of CVP. Correlation with invasively measured pressure was strongest when CVP is > 10 mmHg.
Exploring Staff Implementation of a Self-directed Parenting Intervention for Parents with Mental Health Difficulties
Authors: Butler J. , Gregg L. , Calam R. , Wittkowski A.
Published: May 2020

Parents with mental health difficulties face significant barriers in accessing evidence-based parenting interventions. Self-directed approaches may be a destigmatising, accessible alternative. Evidence has suggested that Triple P Positive Parenting Programme’s self-directed format is as effective as more time- and cost-intensive delivery methods. The aim of the current study was to establish whether staff were able to use this intervention with parents with mental health difficulties and to explore staff experiences of implementation. Triple P self-help workbooks were provided to practitioners across three teams. Data were collected regarding workbook uptake and use. Interviews with staff exploring their experiences of implementation were analysed using thematic analysis. Overall, 41 participants were recruited, of which 12 (29.27%) also consented to interviews. Overall, six practitioners (14.63%) reported that they utilised the workbook. Uptake and utilisation were varied, but practitioners who used the workbook reported positive outcomes. Interviews revealed themes regarding practitioner concerns, views of the intervention and implementation issues. Self-directed Triple remains a promising intervention but its feasibility is dependent on addressing barriers to implementation and facilitating a family-focused approach to meet the needs of these parents and their children.
Attentional Bias for Cues Signaling Punishment and Reward in Adolescents: Cross-Sectional and Prognostic Associations with Symptoms of Anxiety and Behavioral Disorders
Authors: Kreuze L. J. , Jonker N. C. , Hartman C. A. , Nauta M. H. , de Jong P. J.
Published: May 2020

Heightened reward sensitivity has been proposed as a risk factor for developing behavioral disorders whereas heightened punishment sensitivity has been related to the development of anxiety disorders in youth. Combining a cross-sectional (n = 696, mean age = 16.14) and prospective (n = 598, mean age = 20.20) approach, this study tested the hypotheses that an attentional bias for punishing cues is involved in the development of anxiety disorders and an attentional bias for rewarding cues in the development of behavioral disorders. A spatial orientation task was used to examine the relation between an attentional bias for punishing cues and an attentional bias for rewarding cues with anxiety and behavioral problems in a subsample of a large prospective population cohort study. Our study indicates that attentional biases to general cues of punishment and reward do not seem to be important risk factors for the development of anxiety or behavioral problems respectively. It might be that attentional biases play a role in the maintenance of psychological problems. This remains open for future research.
Building Strategies into QBF Proofs
Authors: Beyersdorff Olaf , Blinkhorn Joshua , Mahajan Meena
Published: May 2020

Strategy extraction is of great importance for quantified Boolean formulas (QBF), both in solving and proof complexity. So far in the QBF literature, strategy extraction has been algorithmically performedfromproofs. Here we devise the first QBF system where (partial) strategies are builtintothe proof and are piecewise constructed by simple operations along with the derivation. This has several advantages: (1) lines of our calculus have a clear semantic meaning as they are accompanied by semantic objects; (2) partial strategies are represented succinctly (in contrast to some previous approaches); (3) our calculus has strategy extraction by design; and (4) the partial strategies allow new sound inference steps which are disallowed in previous central QBF calculi such as Q-Resolution and long-distance Q-Resolution. The last item (4) allows us to show an exponential separation between our new system and the previously studied reductionless long-distance resolution calculus. Our approach also naturally lifts to dependency QBFs (DQBF), where it yields the first sound and complete CDCL-style calculus for DQBF, thus opening future avenues into CDCL-based DQBF solving.
From QBFs to MALL and Back via Focussing
Authors: Das Anupam
Published: May 2020

In this work we investigate how to extract alternating time bounds from ‘focussed’ proof systems. Our main result is the obtention of fragments of $$\mathsf {MALL} {\mathsf {w} }$$

MALL
w

($$\mathsf {MALL} $$
MALL
with weakening) complete for each level of the polynomial hierarchy. In one direction we encode QBF satisfiability and in the other we encode focussed proof search, and we show that the composition of the two encodings preserves quantifier alternation, yielding the required result. By carefully composing with well-known embeddings of $$\mathsf {MALL} {\mathsf {w} }$$

MALL
w

into $$\mathsf {MALL} $$
MALL
, we obtain a similar delineation of $$\mathsf {MALL} $$
MALL
formulas, again carving out fragments complete for each level of the polynomial hierarchy. This refines the well-known results that both $$\mathsf {MALL} {\mathsf {w} }$$

MALL
w

and $$\mathsf {MALL} $$
MALL
are $$\mathbf {PSPACE}$$
PSPACE
-complete. A key insight is that we have to refine the usual presentation of focussing to account for deterministic computations in proof search, which correspond to invertible rules that do not branch. This is so that we may more faithfully associate phases of focussed proof search to their alternating time complexity. This presentation seems to uncover further dualities, at the level of proof search, than usual presentations, so could be of proof theoretic interest in its own right.
Impact of COVID-19 Outbreak on Healthcare Workers in Italy: Results from a National E-Survey
Authors: Felice Carla , Di Tanna Gian Luca , Zanus Giacomo , Grossi Ugo
Published: May 2020

Italy has been the first-hit European country to face the outbreak of coronavirus disease 2019 (COVID-19). Aim of this survey was to assess in depth the impact of the outbreak on healthcare workers (HCW). A 40-item online survey was disseminated via social media inviting Italian HCW, with questions exploring demographics, health status and work environment of respondents. A total of 527 were invited to take part in March 2020, of whom 74% (n = 388) responded to the survey. Of these, 235 (61%) were women. HCW were mostly physicians (74%), from high-prevalence regions (52%). 25% experienced typical symptoms during the last 14 days prior to survey completion, with only 45% of them being tested for COVID-19. Among the tested population, 18 (18%) resulted positive for COVID-19, with 33% being asymptomatic. Only 22% of HCW considered personal protective equipment adequate for quality and quantity. Females and respondents working in high-risk sectors were more likely to rate psychological support as useful (OR, 1.78 [CI 95% 1.14–2.78] P = 0.012, and 2.02 [1.12–3.65] P = 0.020, respectively) and workload as increased (mean increase, 0.38 [0.06–0.69] P = 0.018; and 0.54 [0.16–0.92] P = 0.005, respectively). The insights from this survey may help authorities in countries where COVID-19 epidemic has not yet broken out. Management strategies should be promptly undertaken in order to enhance safety and optimise resource allocation.
Lacan on Trauma and Causality: A Psychoanalytic Critique of Post-Traumatic Stress/Growth
Authors: Wright Colin
Published: May 2020

This article makes the case for the largely unacknowledged relevance of the thought of the French psychoanalyst, Jacques Lacan, for the emerging field of the medical and/or health humanities. From the 1930s all the way through to the late 1970s, Lacan was deeply concerned with the ethical and political consequences of then-dominant conceptions of the human in the ‘psy’ disciplines. His attempt to ‘humanise’ these disciplines involved an emphasis on humans as symbolic beings, inevitably entangled in the structures of speech and the ‘logic of the signifier.’ This article explores the implications of Lacan’s linguistic framework for his understanding of trauma. It argues that the Lacanian concept of trauma offers a timely antidote to dominant psychiatric notions of trauma today, linked as they are to the questionable politics of ‘Post-Traumatic Stress Disorder’ and, more recently, of ‘Post-Traumatic Growth.’
Quantitative Rates of Convergence to Non-equilibrium Steady State for a Weakly Anharmonic Chain of Oscillators
Authors: Menegaki Angeliki
Published: May 2020

We study a 1-dimensional chain of N weakly anharmonic classical oscillators coupled at its ends to heat baths at different temperatures. Each oscillator is subject to pinning potential and it also interacts with its nearest neighbors. In our set up both potentials are homogeneous and bounded (with N dependent bounds) perturbations of the harmonic ones. We show how a generalised version of Bakry–Emery theory can be adapted to this case of a hypoelliptic generator which is inspired by Baudoin (J Funct Anal 273(7):2275-2291, 2017). By that we prove exponential convergence to non-equilibrium steady state in Wasserstein–Kantorovich distance and in relative entropy with quantitative rates. We estimate the constants in the rate by solving a Lyapunov-type matrix equation and we obtain that the exponential rate, for the homogeneous chain, has order bigger than $$N^{-3}$$

N

-
3

. For the purely harmonic chain the order of the rate is in $$ [N^{-3},N^{-1}]$$

[

N

-
3

,

N

-
1

]

. This shows that, in this set up, the spectral gap decays at most polynomially with N.
Land use change drives the spatio-temporal variation of ecosystem services and their interactions along an altitudinal gradient in Brazil
Authors: Gomes Lucas Carvalho , Bianchi Felix J. J. A. , Cardoso Irene M. , Fernandes Filho Elpídio I. , Schulte Rogier P. O.
Published: May 2020

Context

Land use and land cover (LULC) changes may affect the provision of ecosystem services. However, little is known how LULC changes influence the spatio-temporal variation in ecosystem service and their interactions along altitudinal gradients.

Objectives

Here we assessed the spatio-temporal variation of eight ecosystem services in an altitudinal gradient between the year of 1986 and 2015, and quantified the effect of LULC transitions on the provision and interactions of ecosystems services.

Methods

We modelled and mapped eight ecosystem services in an altitudinal gradient characterized by low (< 600 m), middle (600–1200) and high altitudes (> 1200) in Zona da Mata, Minas Gerais state, Brazil. We quantified changes in ecosystem services by contrasting ecosystem service maps between 1986 and 2015, and explored how four common LULC transitions affected the variation and the interactions between the eight ecosystem services.

Results

The spatio-temporal analysis indicated that six out of eight ecosystem services increased from 1986 to 2015, while soil erosion control and water flow regulation decreased. In areas above 1200 m, regulating services dominated, while in areas below 1200 m provisioning service were most evidenced. LULC transitions from forest to agricultural areas, and vice versa, resulted in trade-offs between provisioning and regulating ecosystem services.

Conclusions

LULC changes drive the spatio-temporal variation of ecosystem services along an altitudinal gradient with contrasting biophysical conditions. Future management of ecosystem services in the landscapes should take into the account the biophysical conditions and the consequences of specific LULC transitions.
Flagging incorrect nucleotide sequence reagents in biomedical papers: To what extent does the leading publication format impede automatic error detection?
Authors: Labbé Cyril , Cabanac Guillaume , West Rachael A. , Gautier Thierry , Favier Bertrand , Byrne Jennifer A.
Published: May 2020

In an idealised vision of science the scientific literature is error-free. Errors reported during peer review are supposed to be corrected prior to publication, as further research establishes new knowledge based on the body of literature. It happens, however, that errors pass through peer review, and a minority of cases errata and retractions follow. Automated screening software can be applied to detect errors in manuscripts and publications. The contribution of this paper is twofold. First, we designed the erroneous reagent checking () benchmark to assess the accuracy of fact-checkers screening biomedical publications for dubious mentions of nucleotide sequence reagents. It comes with a test collection comprised of 1679 nucleotide sequence reagents that were curated by biomedical experts. Second, we benchmarked our own screening software called Seek&Blastn with three input formats to assess the extent of performance loss when operating on various publication formats. Our findings stress the superiority of markup formats (a 79% detection rate on XML and HTML) over the prominent PDF format (a 69% detection rate at most) regarding an error flagging task. This is the first published baseline on error detection involving reagents reported in biomedical scientific publications. The benchmark is designed to facilitate the development and validation of software bricks to enhance the reliability of the peer review process.
Language-bound terms—term-bound languages: the difficulties of translating a national civil code into a lingua franca
Authors: Fuglinszky Ádám , Somssich Réka
Published: May 2020

The present paper—taking the example of the English translation of the Hungarian Civil Code of 2013—aims to give an overview on the legal and terminology-related challenges and pitfalls that might occur during the process of translating a civil code with civil law traditions into the language of the common law world. An attempt is made to categorise terminology-related conceptual problems and elaborate how the different types of translation methods (functional equivalence, paraphrasing and neologism) could be applied; moreover, how a kind of legal-linguistic checks-and-balances can be achieved through the well-dosed combination, having also the ratio of similarities to differences (SD-ratio or SD-relationship) of legal concepts behind the respective terms in mind. Legal translators must act beyond the role of a simple translator: they must be comparatists, being aware of the legal origin of the relevant concepts and using the methods of comparative private law and translation studies at the same time, since both law and language are system-bound and are heavily influenced by the cultural and social environment. The authors strive to identify the significance of those problems (and possible solutions) from the perspective of how language-related aspects can perform some fine-tuning on the comparative methodology and findings, whether they are barriers only or provide also an opportunity to verify or refuteprima faciecomparative results. Comparative law—no doubt—supports legal translation, but their relationship is reciprocal: legal-linguistic subjects and problems emerging in the course of legal translation supply valuable feedback and further sources of inspiration.
Leveraging spatial uncertainty for online error compensation in EMT
Authors: Krumb Henry , Hofmann Sofie , Kügler David , Ghazy Ahmed , Dorweiler Bernhard , Bredemann Judith , Schmitt Robert , Sakas Georgios , Mukhopadhyay Anirban
Published: May 2020

Purpose

Electromagnetic tracking (EMT) can potentially complement fluoroscopic navigation, reducing radiation exposure in a hybrid setting. Due to the susceptibility to external distortions, systematic error in EMT needs to be compensated algorithmically. Compensation algorithms for EMT in guidewire procedures are only practical in an online setting.

Methods

We collect positional data and train a symmetric artificial neural network (ANN) architecture for compensating navigation error. The results are evaluated in both online and offline scenarios and are compared to polynomial fits. We assess spatial uncertainty of the compensation proposed by the ANN. Simulations based on real data show how this uncertainty measure can be utilized to improve accuracy and limit radiation exposure in hybrid navigation.

Results

ANNs compensate unseen distortions by more than 70%, outperforming polynomial regression. Working on known distortions, ANNs outperform polynomials as well. We empirically demonstrate a linear relationship between tracking accuracy and model uncertainty. The effectiveness of hybrid tracking is shown in a simulation experiment.

Conclusion

ANNs are suitable for EMT error compensation and can generalize across unseen distortions. Model uncertainty needs to be assessed when spatial error compensation algorithms are developed, so that training data collection can be optimized. Finally, we find that error compensation in EMT reduces the need for X-ray images in hybrid navigation.
Lithological indicators of discontinuities in mountain soils rich in calcium carbonate in the Polish Carpathians
Authors: Kowalska Joanna Beata , Kajdas Bartłomiej , Zaleski Tomasz
Published: May 2020

Six soils located within the Polish Carpathians, developed on calcium carbonate–rich sedimentary parent materials and representing various reference groups, were investigated in order to detect the lithic discontinuity. We propose using a multidirectional approach to assess the lithic discontinuity in these soils, one that includes grain size distribution, geochemical composition, heavy mineral content and micromorphology, supported by a traditional soil survey. A further aim of this process was to identify the possible admixture of allochthonous material of aeolian origin. The studied soils presented lithic discontinuities mostly at the contact of underlying calcium carbonate–rich coarsegrained slope deposits with the overlaying colluvium layer having a lower content of rock fragments. The significant changes in grain size distribution, especially in the silt and sand content, as well as high Uniformity Values and partially, high Lithological Discontinuity Index values, confirmed the occurrence of a lithic discontinuity in all studied soils. High heterogeneity in the soil profiles was also confirmed by the distribution of the major oxides; however, their distribution did not clearly indicate the lithic discontinuity. The most visible distinctions were noted from CaO content, which resulted from the deposition of carbonate-free materials (aeolian silts) and their mixing with the calcium carbonate–rich parent material. Furthermore, the analysis of heavy mineral content confirmed the allochthonous origin of the upper (and in some cases also the middle) parts of all profiles, which was manifested by the presence of highly weathering-resistant minerals such as zircon, epidote and various types of garnets. The micromorphological features of some of the studied soils showed distinctiveness within the soil profile, manifested by changes in b-fabric pattern, the occurrence and distribution of secondary carbonate and the coarse and fine coarse and fine ratio. Based on the high content of silt within the upper and middle parts of the soils, the content of Hf and Zr, as well as the higher content of weathering-resistant minerals, admixture of aeolian silt could be considered in some of the studied soils, yet with weak character. However, the dominance of minerals typical for metamorphic and igneous rocks suggested that the supply of aeolian silt was associated with loess covers rather than local sedimentary material.
Psychopharmacological Medication Has No Influence on Vitamin Status After Bariatric Surgery in Long-term Follow-up
Authors: Beiglböck Hannes , Kautzky Alexander , Fellinger Paul , Ranzenberger-Haider Tamara , Itariu Bianca , Wrba Thomas , Prager Gerhard , Kautzky-Willer Alexandra , Wolf Peter , Krebs Michael
Published: May 2020

Context

A substantial number of patients undergoing bariatric surgery are prescribed psychopharmacological medication. However, the impact of concomitant psychopharmacological medication on the frequency of relevant vitamin deficiencies in postoperative follow-up is not known.

Methods

Five hundred twenty-four patients with obesity who underwent bariatric surgery (January 2004 to September 2018) with follow-up of at least 12 months, were included in retrospective analysis. Postoperative follow-up visits between January 2015 and September 2019 were analyzed. Anthropometric and laboratory data were analyzed at the first documented follow-up visit after on average 39.5 ± 37.3 months and at every following visit during the observation period. Patients with prescribed psychopharmacological drugs (PD) were compared with patients without (control group, CON).

Results

Psychopharmacological medication was documented in 25% (132) of patients. In 59 patients documented prescription of more than one psychiatric drug was found, whereas psychopharmacological monotherapy was found in 73 patients. Frequencies of vitamin deficiencies were comparable between PD and CON (vitamin A: p = 0.852; vitamin D: p = 0.622; vitamin E: p = 0.901; folic acid: p = 0.941). Prevalence of vitamin B12 deficiency was rare (6% CON, 1% PD) but was significantly higher in CON (p = 0.023). A comparison of CON and POLY also showed no significant differences between the groups concerning prevalence of vitamin deficiencies.

Conclusions

Intake of psychopharmacological medication is highly prevalent in patients after bariatric surgery. Patients with psychopharmacological medication, who participate in structured follow-up care after bariatric surgery, are not at higher risk for vitamin deficiencies compared with controls.
Incremental Prognostic Value of Coagulopathy in Addition to the Crash Score in Traumatic Brain Injury Patients
Authors: Solla Davi J. Fontoura , de Amorim Robson Luis Oliveira , Kolias Angelos G. , Hutchinson Peter J. , de Andrade Almir Ferreira , Teixeira Manoel Jacobsen , Paiva Wellingson Silva
Published: May 2020

Background/objective

Multivariable prognostic scores play an important role for clinical decision-making, information giving to patients/relatives, benchmarking and guiding clinical trial design. Coagulopathy has been implicated on trauma and critical care outcomes, but few studies have evaluated its role on traumatic brain injury (TBI) outcomes. Our objective was to verify the incremental prognostic value of routine coagulopathy parameters in addition to the CRASH-CT score to predict 14-day mortality in TBI patients.

Methods

This is a prospective cohort of consecutive TBI patients admitted to a tertiary university hospital Trauma intensive care unit (ICU) from March/2012 to January/2015. The prognostic performance of the coagulation parameters platelet count, prothrombin time (international normalized ratio, INR) and activated partial thromboplastin time (aPTT) ratio was assessed through logistic regression adjusted for the original CRASH-CT score. A new model, CRASH-CT-Coag, was created and its calibration (Brier scores and Hosmer–Lemeshow (H–L) test), discrimination [area under the receiver operating characteristic curve (AUC-ROC) and the integrated discrimination improvement (IDI)] and clinical utility (net reclassification index) were compared to the original CRASH-CT score.

Results

A total 517 patients were included (median age 39 years, 85.1% male, median admission glasgow coma scale 8, neurosurgery on 44.9%). The 14-day mortality observed and predicted by the original CRASH-CT was 22.8% and 26.2%, respectively. Platelet count < 100,000/mm3, INR > 1.2 and aPTT ratio > 1.2 were present on 11.3%, 65.0% and 27.2%, respectively, (at least one of these was altered on 70.6%). All three variables maintained statistical significance after adjustment for the CRASH-CT score. The CRASH-CT-Coag score outperformed the original score on calibration (brier scores 0.122 ± 0.216 vs 0.132 ± 0.202, mean difference 0.010, 95% CI 0.005–0.019, p = 0.036, respectively) and discrimination (AUC-ROC 0.854 ± 0.020 vs 0.813 ± 0.024, p = 0.014; IDI 5.0%, 95% CI 1.3–11.0%). Both scores showed the satisfactory H–L test results. The net reclassification index favored the new model. Considering the strata of low (< 10%), moderate (10–30%) and high (> 30%) risk of death, the CRASH-CT-Coag model yielded a global net correct reclassification of 22.9% (95% CI 3.8–43.4%).

Conclusions

The addition of early markers of coagulopathy—platelet count, INR and aPTT ratio—to the CRASH-CT score increased its accuracy. Additional studies are required to externally validate this finding and further investigate the coagulopathy role on TBI outcomes.
The Xinjiang Case and Its Implications from a Business Ethics Perspective
Authors: Kriebitz Alexander , Max Raphael
Published: May 2020

The discourse on economic integration with authoritarian regimes has evolved as a key topic throughout the different disciplines of social sciences. Are sanctions and boycotts effective methods to incentivize human rights improvements? To analyze this question, we focus on the situation in China’s Xinjiang province from 2010 to 2019. In this paper, we discuss the relevance of human rights as an ethical norm within business ethics and international law. We evaluate the ongoing processes in Xinjiang from this perspective and scrutinize the interests of major players in the region, including the Central Government of the People’s Republic of China, Xinjiang’s local government, and enterprises involved in the region. Following this, we discuss which economic measures will improve the human rights situation and how these measures contribute to an improvement of the situation.
Weighted norm inequalities in a bounded domain by the sparse domination method
Authors: Kurki Emma-Karoliina , Vähäkangas Antti V.
Published: May 2020

We prove a local two-weight Poincaré inequality for cubes using the sparse domination method that has been influential in harmonic analysis. The proof involves a localized version of the Fefferman–Stein inequality for the sharp maximal function. By establishing a local-to-global result in a bounded domain satisfying a Boman chain condition, we show a two-weight p-Poincaré inequality in such domains. As an application we show that certain nonnegative supersolutions of the p-Laplace equation and distance weights are p-admissible in a bounded domain, in the sense that they support versions of the p-Poincaré inequality.