bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell-Type-Dependent Role for nsP3 Macrodomain ADP-Ribose Binding and Hydrolase Activity during Chikungunya Virus Infection
Authors: Kim Taewoo , Abraham Rachy , Pieterse Lisa , Yeh Jane X. , Griffin Diane E.
Published: December 2022

Chikungunya virus (CHIKV) causes outbreaks of rash, arthritis, and fever associated with neurologic complications, where astrocytes are preferentially infected. A determinant of virulence is the macrodomain (MD) of nonstructural protein 3 (nsP3), which binds and removes ADP-ribose (ADPr) from ADP-ribosylated substrates and regulates stress-granule disruption. We compared the replication of CHIKV 181/25 (WT) and MD mutants with decreased ADPr binding and hydrolase (G32S) or increased ADPr binding and decreased hydrolase (Y114A) activities in C8-D1A astrocytic cells and NSC-34 neuronal cells. WT CHIKV replication was initiated more rapidly with earlier nsP synthesis in C8-D1A than in NSC-34 cells. G32S established infection, amplified replication complexes, and induced host-protein synthesis shut-off less efficiently than WT and produced less infectious virus, while Y114A replication was close to WT. However, G32S mutation effects on structural protein synthesis were cell-type-dependent. In NSC-34 cells, E2 synthesis was decreased compared to WT, while in C8-D1A cells synthesis was increased. Excess E2 produced by G32S-infected C8-D1A cells was assembled into virus particles that were less infectious than those from WT or Y114A-infected cells. Because nsP3 recruits ADP-ribosylated RNA-binding proteins in stress granules away from translation-initiation factors into nsP3 granules where the MD hydrolase can remove ADPr, we postulate that suboptimal translation-factor release decreased structural protein synthesis in NSC-34 cells while failure to de-ADP-ribosylate regulatory RNA-binding proteins increased synthesis in C8-D1A cells.
Changes following the Onset of the COVID-19 Pandemic in the Burden of Hospitalization for Respiratory Syncytial Virus Acute Lower Respiratory Infection in Children under Two Years: A Retrospective Study from Croatia
Authors: Mrcela Dina , Markic Josko , Zhao Chenkai , Viskovic Daniela Veljacic , Milic Petra , Copac Roko , Li You
Published: December 2022

To understand the changes in RSV hospitalization burden in children younger than two years following the onset of the COVID-19 pandemic, we reviewed hospital records of children with acute lower respiratory infection (ALRI) between January 2018 and June 2022 in Split-Dalmatia County, Croatia. We compared RSV activity, age-specific annualized hospitalization rate, and disease severity between pre-COVID-19 and COVID-19 periods. A total of 942 ALRI hospital admissions were included. RSV activity remained low for the typical RSV epidemic during 2020–2021 winter. An out-of-season RSV resurgence was observed in late spring and summer of 2021. Before the COVID-19 pandemic, the annualized hospitalization rate for RSV-associated ALRI was 13.84/1000 (95% CI: 12.11–15.76) and highest among infants under six months. After the resurgence of RSV in the second half of 2021, the annualized hospitalization rate for RSV-associated ALRI in children younger than two years returned to the pre-pandemic levels with similar age distribution but a statistically higher proportion of severe cases. RSV immunization programs targeting protection of infants under six months of age are expected to remain impactful, although the optimal timing of administration would depend on RSV seasonality that has not yet been established in the study setting since the onset of the COVID-19 pandemic.
The Development of Technology to Prevent, Diagnose, and Manage Antimicrobial Resistance in Healthcare-Associated Infections
Authors: Elbehiry Ayman , Marzouk Eman , Abalkhail Adil , El-Garawany Yasmine , Anagreyyah Sulaiman , Alnafea Yaser , Almuzaini Abdulaziz M. , Alwarhi Waleed , Rawway Mohammed , Draz Abdelmaged
Published: December 2022

There is a growing risk of antimicrobial resistance (AMR) having an adverse effect on the healthcare system, which results in higher healthcare costs, failed treatments and a higher death rate. A quick diagnostic test that can spot infections resistant to antibiotics is essential for antimicrobial stewardship so physicians and other healthcare professionals can begin treatment as soon as possible. Since the development of antibiotics in the last two decades, traditional, standard antimicrobial treatments have failed to treat healthcare-associated infections (HAIs). These results have led to the development of a variety of cutting-edge alternative methods to combat multidrug-resistant pathogens in healthcare settings. Here, we provide an overview of AMR as well as the technologies being developed to prevent, diagnose, and control healthcare-associated infections (HAIs). As a result of better cleaning and hygiene practices, resistance to bacteria can be reduced, and new, quick, and accurate instruments for diagnosing HAIs must be developed. In addition, we need to explore new therapeutic approaches to combat diseases caused by resistant bacteria. In conclusion, current infection control technologies will be crucial to managing multidrug-resistant infections effectively. As a result of vaccination, antibiotic usage will decrease and new resistance mechanisms will not develop.
Strategies to Increase the Percentages of Vaccination Coverage
Authors: Plans-Rubió Pedro
Published: December 2022

In 2012, the WHO proposed the Global Vaccine Action Plan (GVAP) 2011–2020 to promote essential or routine vaccines among all children of the world [...]
COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
Authors: Nasrullah Adeel , Gangu Karthik , Shumway Nichole B. , Cannon Harmon R. , Garg Ishan , Shuja Hina , Bobba Aniesh , Chourasia Prabal , Sheikh Abu Baker , Shekhar Rahul
Published: December 2022

Venous thromboembolism, in particular, pulmonary embolism (PE), is a significant contributor to the morbidity and mortality associated with COVID-19. In this study, we utilized the National Inpatient Sample (NIS) database 2020 to evaluate and compare clinical outcomes in patients with COVID-19 with and without PE. Our sample includes 1,659,040 patients hospitalized with COVID-19 pneumonia between January 2020 and December 2020. We performed propensity-matched analysis for patient characteristics and in-hospital outcomes, including the patient’s age, race, sex, insurance status, median income, length of stay, mortality, hospitalization cost, comorbidities, mechanical ventilation, and vasopressor support. Patients with COVID-19 with PE had a higher need for mechanical ventilation (25.7% vs. 15.6%, adjusted odds ratio 1.4, 95% CI 1.4–1.5, p < 0.001), the vasopressor requirement (5.4% vs. 2.6%, adjusted OR 1.6, 95% CI 1.4–1.8, p < 0.001), longer hospital stays (10.8 vs. 7.9 days, p < 0.001), and overall higher in-hospital mortality (19.1 vs. 13.9%, adjusted OR of 1.3, 95% CI 1.1–1.5, p < 0.001). This study highlights the need for more aggressive management of PE in COVID-19-positive patients with the aim to improve early diagnosis and treatment to reduce morbidity, mortality, and healthcare costs seen in the synchronous COVID-19 and PE-positive patients.
Investigate Non-EPI Vaccination Recommendation Practice from a Socio-Ecological Perspective: A Mixed-Methods Study in China
Authors: Han Kaiyi , Hou Zhiyuan , Tu Shiyi , Wang Qian , Wang Binbing , Liu Xiaoyu , Jiang Shiqiang , Chantler Tracey , Larson Heidi
Published: December 2022

The uptake of non-EPI vaccines, such as influenza and pneumonia vaccines, are very low in China compared to other countries. In China, immunization services are provided by dedicated vaccination service providers (VSPs), and their recommendation is the key to improve vaccine uptake. This study explores VSP recommendation practices for non-EPI vaccines from a socio-ecological perspective. A mixed-methods study, combining a questionnaire survey and key informant interviews, was conducted in Anhui, Shaanxi, and Guangdong provinces. 555 VSPs completed the valid questionnaire, and 49 VSPs participated in in-depth interviews. Among the surveyed VSPs, 51.54% stated that they always or often recommended non-EPI vaccines in work, and the remaining half reported that they sometimes or never recommended non-EPI vaccines. Most VSPs interviewed communicated about non-EPI vaccines with the public in an informed style, not a presumptive one, and provided the public with all the decision-making latitude. The infrequent recommendation of non-EPI vaccines was widely prevalent among Chinese VSPs regardless of their individual characteristics, and was mainly driven by the interpersonal relationship, institutional arrangement, and public policy. Firstly, the VSPs were concerned about conflicts arising from the recommendation of self-paid vaccines and the risk of adverse reactions following vaccination. Secondly, high workloads left them insufficient time to communicate about non-EPI vaccines. Thirdly, there was no performance assessment or financial incentive for VSPs to recommend non-EPI vaccination, and their main responsibility was around EPI vaccination. Therefore, multi-level socio-ecological systems around non-EPI vaccination should be improved to optimize the communication between VSPs and the public, which include a better system of legal redress to resolve potential misunderstandings between the VSPs and the public, more effective workload management through whole-process health information system and strengthening public health workforce, and the introduction of performance assessment and appropriate incentives on non-EPI vaccination.
Evaluation of Potential Seawater Intrusion in the Coastal Aquifers System of Benin and Effect of Countermeasures Considering Future Sea Level Rise
Authors: Agossou Amos , Yang Jeong-Seok , Lee Jae-Boem
Published: December 2022

In the present study, a three-dimensional SEAWAT model was developed to generally simulate the impact of climate change and anthropogenic activities on seawater intrusion (SWI) in the coastal region of Benin by the end of 2050. The model was calibrated and validated from 2015 to 2020, considering groundwater head and salt concentration measured in 30 wells. After calibration, a sensitivity analysis was performed with the model parameters (hydraulic conductivity, recharge, storage coefficient and boundary conditions). For the calibration, model computed and observed values displayed good correlation, approximatively 0.82 with a root mean square error (RMSE) of 0.97 m and 13.38 mg/L for groundwater head and salt concentration, respectively. The simulation results indicate that freshwater head had declined by 1.65 m from 2015 to 2020 (taking reference from the average groundwater head in 2015: 27.08 m), while the seawater intrusion area increased in the same period by an average of 1.92 km2 (taking reference from the seawater intrusion area in 2015: 20.03 km2). The model is therefore used to predict groundwater level decline and seawater intrusion area increase by the end of 2050, considering the predicted sea level rise (SLR) and estimated groundwater pumping rate. Furthermore, the interface fresh groundwater–saltwater change was studied using the SHARP interface developed by USGS in 1990. The interface variation was found to be influenced by the distance from shoreline, sea level, groundwater level and geological formation hydraulic conductivity. Finally, the 3D model was used to simulate the effect of a managed aquifer recharge system on reducing SWI rate in the study region.
Bayesian Calibration and Uncertainty Assessment of HYDRUS-1D Model Using GLUE Algorithm for Simulating Corn Root Zone Salinity under Linear Move Sprinkle Irrigation System
Authors: Moghbel Farzam , Mosaedi Abolfazl , Aguilar Jonathan , Ghahraman Bijan , Ansari Hossein , Gonçalves Maria C.
Published: December 2022

Soil salinization is one of the significant concerns regarding irrigation with saline waters as an alternative resource for limited freshwater resources in arid and semi-arid regions. Thus, the investigation of proper management methods to control soil salinity for irrigation with saline waters is inevitable. The HYDRUS-1D model is a well-known numerical model that can facilitate the exploration of management scenarios to mitigate the consequences of irrigation with saline waters, especially soil salinization. However, before using the model as a decision support system, it is crucial to calibrate the model and analyze the model’s parameters and outputs’ uncertainty. Therefore, the generalized likelihood uncertainty estimation (GLUE) algorithm was implemented for the HYDRUS-1D model in the R environment to calibrate the model and assess the uncertainty aspects for simulating soil salinity of corn root zone under saline irrigation with linear move sprinkle irrigation system. The results of the study have detected a lower level of uncertainty in the α, n, and θs (saturated soil water content) parameters of water flow simulations, dispersivity (λ), and adsorption isotherm coefficient (Kd) parameters of solute transport simulations comparing to the other parameters. A higher level of uncertainty was found for the diffusion coefficient as its corresponding posterior distribution was not considerably changed from its prior distribution. The reason for this phenomenon could be the minor contribution of diffusion to the solute transport process in the soil compared with advection and hydrodynamic dispersion under saline water irrigation conditions. Predictive uncertainty results revealed a lower level of uncertainty in the model outputs for the initial growth stages of corn. The analysis of the predictive uncertainty band also declared that the uncertainty in the model parameters was the predominant source of uncertainty in the model outputs. In addition, the excellent performance of the calibrated model based on 50% quantiles of the posterior distributions of the model parameters was observed in terms of simulating soil water content (SWC) and electrical conductivity of soil water (ECsw) at the corn root zone. The ranges of NRMSE for SWC and ECsw simulations at different soil depths were 0.003 to 0.01 and 0.09 to 0.11, respectively. The results of this study have demonstrated the authenticity of the GLUE algorithm to seek uncertainty aspects and calibration of the HYDRUS-1D model to simulate the soil salinity at the corn root zone at field scale under a linear move irrigation system.
Water Efficiency of Coriander under Flows of Application of Nutritive Solutions Prepared in Brackish Waters
Authors: Bezerra Raphaela Revorêdo , Santos Júnior José Amilton , Pessoa Uriel Calisto , Silva Ênio Farias de França e , Oliveira Tarcísio Ferreira de , Nogueira Kézia Ferreira , Souza Edivan Rodrigues de
Published: December 2022

The impact of the salinity of the nutrient solution on water efficiency can be changed by the application flow. The aim of this work was to analyze the water efficiency and production components of coriander plants, cultivar Verdão, exposed to nutrient solutions (1.7, 3.0, 4.5, and 6.0 dS m−1) applied with different flow rates (1.0, 2.0, 3,0, and 4.0 L min−1) in an NFT hydroponic system. Two experiments were carried out in a greenhouse with two sources of salts to prepare the electrical conductivity. In the first experiment, NaCl was used, and CaCl2·2H2O was used in the second. Variables were analyzed related to the production components and the consumption of water use efficiency. It was found that the water efficiency and production components of coriander plants were more affected by increases in electrical conductivity in the nutrient solution. CaCl2·2H2O better promotes the lower production of dry mass, plant height, water consumption, and the instantaneous and intrinsic efficiency of water use than NaCl. The coriander’s water relations were inhibited by increases in the concentration of salts in nutrient solution, while increases in the flow rate of the nutrient solution negatively affected the productive parameters of the coriander plants.
Dynamics of Pollution in the Hyporheic Zone during Industrial Processing Brine Discharge
Authors: Parshakova Yanina , Ivantsov Andrey
Published: December 2022

The industrial production of chemicals, including the manufacture of mineral fertilizers, is often associated with the need for the disposal of highly mineralized brines through their discharge into surface water bodies or an underground water-bearing layer. When dealing with surface water bodies, the problem of the hyporheic zone effect could substantially influence the process and, thus, must be examined. We consider a two-layer system (liquid–porous medium) for a detailed assessment of the importance of considering the hyporheic zone during the modeling of brine discharge. A three-dimensional numerical simulation of brine transport is performed for parameters close to the characteristics of the media and flows typical for natural water bodies. The dynamics of a saturated brine in a two-layer system are studied for the period of brine discharging and after the cessation of the disposal, and the accumulation of salts in the bottom porous layer is assessed. Calculations show that a significant amount of impurities is observed not only near the water body bottom but also throughout the entire thickness of the porous layer. Moreover, the obtained data reveal that the effect of vertical stratification dramatically influences the brine discharge process and leads to propagation of the brine into the porous medium with a velocity that is three orders of magnitude higher than the filtration rate in the horizontal direction. As a result, the heterogeneity in the depth distribution of the impurity concentration is significant. In particular, the maximum concentration of salt in the hyporheic zone exceeds those near the river surface by hundreds of times. Impurities accumulated in the water-bearing layer of the river bottom are nonhazardous at low- and medium-flow rates. However, with an increase in the river flow intensity—for example, during the flood period or caused by operating regime of a hydroelectric power plant—the accumulated contamination may become an intensive source of pollution, which significantly limits the water use regime.
Modeling of Groundwater Nitrate Contamination Due to Agricultural Activities—A Systematic Review
Authors: Rawat Meenakshi , Sen Rintu , Onyekwelu Ikenna , Wiederstein Travis , Sharda Vaishali
Published: December 2022

Groundwater nitrate contamination is a significant concern in agricultural watersheds worldwide with it becoming a more pervasive problem in the last three decades. Models are great tools that are used to identify the sources and spatial patterns of nitrate contamination of groundwater due to agricultural activities. This Systematic Review (SR) seeks to provide a comprehensive overview of different models used to estimate nitrate contamination of groundwater due to agricultural activities. We described different types of models available in the field of modeling groundwater nitrate contamination, the models used, the input requirements of different models, and the evaluation metrics used. Out of all the models reviewed, stand-alone process-based models are predominantly used for modeling nitrate contamination, followed by integrated models, with HYDRUS and LEACHM models being the two most commonly used process-based models worldwide. Most models are evaluated using the statistical metric Root Mean Square Error (RMSE) followed by the correlation coefficient (r). This study provides the current basis for model selection in modeling nitrate contamination of groundwater due to agricultural activities. In addition, it also provides a clear and concise picture of the state of the art and implications to the scientific community doing groundwater quality modeling studies.
Evaluating a Surface Energy Balance Model for Partially Wetted Surfaces: Drip and Micro-Sprinkler Systems in Hazelnut Orchards (Corylus Avellana L.)
Authors: Souto Camilo , Lagos Octavio , Holzapfel Eduardo , Ruybal Christopher , Bryla David , Vidal Gladys
Published: December 2022

A multi-layer surface energy balance model was previously developed to estimate crop transpiration (T) and soil evaporation (E) in orchards partially wet by micro-irrigation systems. The model, referred to as SEB-PW, estimates latent (λE), sensible (H), and soil heat fluxes (G) and separates actual evapotranspiration (ETa) into dry and wet soil E and crop T. The main goal of this work was to evaluate the ability of the SEB-PW model to estimate ETa and analyze the diurnal and seasonal dynamics of E and T in two hazelnut (Corylus avellana L.) orchards irrigated by drip or micro-sprinkler systems. The assessment showed that simulated hourly ET was highly correlated with estimates from nearby weather stations and with measurements from micro-lysimeters (MLs). Hourly ET estimates were evaluated by root-mean-square error (RMSE), mean absolute error (MAE), the Nash–Sutcliffe coefficient (NSE), and the index of agreement (da), which equaled 58.6 W m−2, 35.6 W m−2, 0.85, and 0.94, respectively. Daily E estimates were also evaluated and equaled 0.27 mm day−1, 0.21 mm day−1, 0.87, and 0.94, respectively, and obtained a coefficient of determination (r2) of 0.85 when compared to the measurements from the MLs. Within a day of irrigation, E accounted for 28 and 46% of ET. In accordance with the obtained results, the proposed SEB-PW model improves estimates of soil E by allowing the wetted and non-wetted areas to be estimated separately, which could be useful for optimizing irrigation methods and practices in hazelnut orchards.
Sub-Hourly to Daily Rainfall Intensity-Duration-Frequency Estimation Using Stochastic Storm Transposition and Discontinuous Radar Data
Authors: Andersen Christoffer B. , Wright Daniel B. , Thorndahl Søren
Published: December 2022

Frequency analysis of rainfall data is essential in the design and modelling of hydrological systems but is often statistically limited by the total observation period. With advances in weather radar technology, frequency analysis of areal rainfall data is possible at a higher spatial resolution. Still, the observation periods are short relative to established rain gauge networks. A stochastic framework, “stochastic storm transposition” shows great promise in recreating rainfall statistics from radar rainfall products, similar to rain gauge-derived statistics. This study estimates intensity–duration–frequency (IDF) relationships at both point and urban catchment scales. We use the stochastic storm transposition framework and a single high-resolution, 17-year long (however, discontinuous), radar rainfall dataset. The IDF relations are directly compared to rain gauge statistics with more than 40 years of observation, and rainfall extremes derived from the original, and untransposed, radar dataset. An overall agreement is discovered, however, with some discrepancies in short-duration storms due to scaling errors between gauge and radar.
Symbolic Regression Based Feature Extraction of Shallow Neural-Networks for Identification and Prediction
Authors:   Izmir Demokrasi University, Electrical and Electronics Engineering, Uckuyular Dist., Karabaglar 35140, Izmir, Turkey, Beyhan Selami
Published: December 2022

This paper proposes a feature extraction method to improve the performance of shallow neural-network models with less number of parameters to apply especially on embedded system design at remote applications. Feature extraction method is designed using fuzzy c-means clustering based fuzzy system design cascaded a layer of symbolic operators and functions, respectively. During the training stage of neural-networks, symbolic operators and functions are selected using random-learning theory with the unity internal weights such that based on the prediction performance, optimal sequences are recorded for feature extraction to be utilized on testing phase. Extracted features are here used to empower the single-layer neural-network (SLNN) with sigmoid hyperbolic activation functions, functional-link neural- network (FLNN) with Chebyshev polynomials and Pi-Sigma higher-order neural-network (PSNN) with sigmoid activation functions, respectively. The internal and output parameters of the appended shallow neural-networks are optimized using batch optimization methods. Proposed regression models are first tested on identification of an artificial discrete-time dynamic system and real-time inverted pendulum then also for prediction of the sunspot time-series and traffic density estimation. As a result, the prediction performance of shallow neural networks is improved to be used in future applications.
El apego en mujeres de 40 a 50 años de edad en el estado de Tabasco
Authors: Osorio-Arias Luciano , Iduarte-García Belgica , Jimenéz-Jiménez Felix
Published: December 2022

Los estilos de apego son el resultado de las primeras relaciones de apego entre un niño y una persona en particular, ya que durante la relación de apego se forman los modelos mentales, los cuales influyen en el desarrollo personal y comportamiento hacia las relaciones interpersonales a lo largo de la vida. El objetivo de la investigación consistió en evaluar e interpretar el estilo de apego que predomina en las mujeres  del Estado de Tabasco de 40 a 50 años  y subrayar la importancia del estilo de apego en el desarrollo de la personalidad de las mujeres . Se aplicó  el Cuestionario CAMIR, el cual mide los estilos de apego y las representaciones mentales del apego, pasadas, presente y el funcionamiento familiar. El papel de la mujer en Tabasco esta relacionado con el tipo de apego que viva desde niña la experiencia que hallan tenido con sus cuidadores tiene un rol fundamental en la capacidad posterior de establecer vínculos afectivos, ya que es importante que la niña pueda depender de sus figuras de apego y que estas puedan contener y protegerla cuando lo necesita.
Pemilihan Layanan Pesan Antar Makanan Online Terbaik Menggunakan Metode Weighted Product
Authors: Nisa Khoirun , Khoirunnisa Tasya
Published: December 2022

Selama masa pandemi masyarakat lebih memilih menggunakan layanan pesan antar makanan online daripada pergi keluar rumah untuk membeli makanan entah itu untuk sarapan, makan siang, makan malam bahkan untuk cemilan. Beberapa layanan pesan makanan antar makanan online memberikan manfaat dan membantu masyarakat untuk tidak harus melakukan transaksi secara langsung di luar rumah. Namun sebagian masyarakat sering merasa kesulitan dalam menentukan layanan pesan makanan antar makanan online mana yang terbaik. Pengumpulan data didapatkan dari penyebaran kuesioner kepada konsumen atau pengguna layanan pesan antar makanan online yaitu masyarakat di Kecamatan Sukmajaya Kota Depok. Selanjutnya data diolah dengan menggunakan metode sistem pendukung keputusan yaitu Metode Weighted Product dengan 4 kriteria yaitu Pelayanan, Promo, Fitur dan Biaya. Untuk pengambilan sampel pada penelitian ini, peneliti memilih menggunakan rumus slovin yang dimana jumlah populasi dibagi dengan hasil dari 1 ditambah jumlah populasi dikali batas kesalahan pangkat 2. Hasil pemilihan layanan pesan antar makanan online yang menerapkan Weighted Product menghasilkan GrabFood sebagai peringkat 1 dengan jumlah nilai Vektor V yaitu 0.337, ShopeeFood peringkat 2 dengan nilai 0.333, dan yang terakhir GoFood dengan nilai 0.329. Tujuan dari penelitian ini agar memudahkan masyarakat untuk menentukan penyedia layanan pesan antar makanan online terbaik di Kecamatan Sukmajaya Kota Depok
Penerapan Metode Monte Carlo pada Simulasi Prediksi Jumlah Calon Mahasiswa Baru Universitas Muhammadiyah Bengkulu
Authors: Yovi  , Ringgo Dwika  , Eka
Published: December 2022

Dengan adanya sistem simulasi prediksi jumlah mahasiswa baru ini, diharapkan dapat memprediksi jumlah mahasiswa baru yang masuk pada setiap tahun kedepan nya. Menerapkan metode Monte Carlo dan juga menerapkan aplikasi simulasi prediksi dapat mempermudah dalam menentukan jumlah penerimaan mahasiswa baru pada Universitas Muhammadiyah Bengkulu. Pengumpulan data yang dilakukan dengan cara obeservasi secara langsung ke objek dengan mengambil sampel data yang sudah ada di tahun 2015 â€“ 2019. Dalam penelitian ini digunakan  metode monte carlo untuk prediksi calon  mahasiswa baru. Tujuan dari penelitian ini untuk mengetahui jumlah calon mahasiswa baru, yang diharapkan hasilnya dapat memberikan informasi dan masukan bagi pihak perguruan tinggi dalam membuat kebijakan kedepannya. Dari hasil pengujian ini didapatkan hasil bahwa dengan menerapkan metode monte carlo dapat memprediksi jumlah calon mahasiswa baru, dengan metode monte carlo dan tingkat akurasi sebesar 92.49 %.
Pengembangan Alat Pendeteksi Kebocoran Liquefied Petroleum Gas dengan Metode Research and Development
Authors: Herfandi
Published: December 2022

Indonesian people already use LPG (Liquefied Petroleum Gas) as the main fuel. LPG has a weakness in the material used is very flammable in air. LPG safety devices are currently ineffective because we cannot know the condition of LPG when we are not at home. The Research and Development method is able to produce and develop products that already exist today and have a high validity value, because they have passed various series of trials. This study develops an LPG leak detector using research and development methods. The result of this study is that the LPG leak detection tool has a call gateway notification feature on two user mobile numbers that have been setup on the microcontroller and have been tested using gas from matches and smoke. The limited test obtained an average score of 80 and is included in the good category, while the wider trial of the developed tool has proven to be more effective than the manual tool currently used. This gas leak detection tool is expected to be able to make it easier for the public to get early notification when an LPG leak occurs and immediately take preventive actions to prevent fires.
Perancangan Aplikasi Point of Sale (POS) pada Karya Maju Jaya
Authors: Martono  , Zulfi
Published: December 2022

Karya maju jaya is one of the shops that engaged in the provision of services and goods in the form of workshops. Currently at karya maju Jaya, the process of managing transactions and financial reports still uses paper media as a means of storing data, causing many weaknesses in terms of security, effectiveness from the aspect of time, higher costs to the high possibility of errors in processing and processing information. Therefore, the author decided to conduct a research that the author gave the title point of sale (POS) application design on the work of karya maju jaya with the aim of answering all the problems above. The point of sale (POS) application in this study will be described using use case diagrams and class diagrams modeling. The final product of the research that the author did in this research is a point of sale (POS) application that allows application users to process product data, manage transaction data, manage reports, manage invoices, manage profiles, change passwords, login and logout.
REVIEW OF URBAN PLANNING AND THE NEEDS OF PEOPLE WITH DISABILITIES IN KABUL CITY
Authors: Amini S. , Simankina T.
Published: December 2022

The paper presents an analysis of the relevance of urban planning to the needs of people with disabilities, namely, people with disabilities living in the city of Kabul, Afghanistan. Based on a case study to collect data to determine the relevance of the urban planning model to the needs of people with disabilities, conducting field observations, as well as using the weighted sum method, quantitative estimates were obtained, on the basis of which it was concluded that urban facilities in Kabul does not meet the physical and administrative needs of people with disabilities. The study found that buildings in Kabul City lacked the necessary standards to meet the needs of people with disabilities
REAL AND VIRTUAL IN THE CITY PUBLIC SPACES OF ST. PETERSBURG
Authors: Tkachenko P. , Per'kova M.
Published: December 2022

The virtual world has become an integral part of human existence in the digital age, so it is very important to establish the nature of the interaction between the virtual and the real or physical world, in which human sensations in urban public space occupy one of the key positions. The possibility of full-fledged proprioception in a virtual environment is considered due to the absence of factors of movement and real action. The role of public spaces is formulated in the context of a shift in emphasis from proprioception in the physical world to proprioception in the digital world as one of the significant factors affecting the perception of the quality of life in the city, the citizen satisfaction and the increase in the influx of tourists. Public spaces of the Admiralteysky district of St. Petersburg of various types and varying degrees of privacy are considered in the article, for example, creative clusters, parks and embankments as a space for communication and social activity. New meanings of central (citywide) public spaces are considered: squares, parks, pedestrian spaces, embankments as an attraction point in terms of our feelings and emotions. Recommendations on the inclusion of a digital virtual environment in the real urban public spaces of St. Petersburg are proposed
Onconephrology 2022: An Update
Authors: Bonilla Marco , Gudsoorkar Prakash , Wanchoo Rimda , Herrmann Sandra M. , Jhaveri Kenar D.
Published: December 2022

Onconephrology is an upcoming and expanding subspecialty that deals with the intersections between hematology/oncology and nephrology. With the paradigm shift in the understanding of cancer immunobiology and mechanisms of oncotherapeutic drug toxicities, it is important for a nephrologist to have a sound understanding of this field. Over the last 5 years, there have been immense developments in our understanding of kidney-related adverse events from various targeted, immuno- and cellular-based therapies. Pathogenic mechanisms of electrolyte imbalance, hypertension (oncohypertension), and AKI from multiple forms of cancer therapies have been explored. Significant research has also been conducted in the field of transplant onconephrology. In this review, we have tried to assimilate the most recent updates in the last 2 years in this ever-growing and fascinating field.
Şâfiî ve Hanbelî Meşhur Usûl Âlimlerinin Mursel Hadise Yaklaşımı
Authors: TURAN Mehmet
Published: December 2022

Bir hadisin sahih kabul edilebilmesi için senedinin muttasıl olması gerekmektedir. Nitekim senedinde bulunan inkıta nedeniyle mürsel rivayetler zayıf kabul edilmiş ve delil olarak kullanılmaya elverişli olmadığı hadisçilerin büyük bir çoğunluğu tarafından dile getirilmiştir. Usûl âlimleri ise mürsel hadisin tanımından tutun da delil olma yönünden değerine kadar hadisçilerden tamamen farklı bir bakış açısı ortaya koymuşlardır. Bu çalışmamızda öncelikle İmam Şafiî’nin (204/820) mürsel hadis yaklaşımı ele alınıp incelenecek, mürsel hadisin kabulü hususunda var olduğu iddia edilen icmâya muhalefet ettiği iddiası tartışılacaktır. Daha sonra ise Şafiî usûl âlimlerinin mürsel hadis yaklaşımı, fıkıh usûlü alanında kaleme alınmış temel eserlerden hareketle saptanmaya çalışılacaktır. Ayrıca çalışmamızda Ahmet b. Hanbel’in bizzat kendi görüşlerinden hareketle mürsel hadis yaklaşımı tespit edilecek ve Hanbelî usûl âlimlerinin mürsel hadis yaklaşımı ana hatlarıyla ele alınıp incelenecektir.
Tamil Vidu Thoothu is a Literary Grammar Expert
Authors: K Jelin Suji , D Mahila Jeni
Published: December 2022

Tamil is the oldest language among all world languages. It is an ancient language, and its origin cannot be defined. It is a language that excels in literary grammars. When looking at the history of Tamil literature, many literary genres have emerged according to time, context, and political backgrounds. Literature tells the stories of people's lives. It relates to grammar in Tamil, and literature itself becomes grammar. Tolkappiyam is a book that exemplifies the grammatical system of the Tamil language with distinction. Letter, word, subject matter, prosody, and rhetoric—these five are dealt with in the book Tolkappiyam. There are many books that arose after that ancient, proud, and complete book of Tolkappiyam. This article examines how grammar in literature has gained prominence through the book Tamil Vidu Thoothu.
A Study of Techniques and Strategies in Azhagar Killai Vidu Thoothu
Authors: B Annalakshmi
Published: December 2022

Virtue, money, pleasure, and home are all symbols; if one or more of these four are absent, it is a weak symbol. The poetry of Azhagar Killai Vidu Thoothu is written in a style that is lovely, straightforward, and elegant. The techniques are founded on a concise and detailed understanding of Tamil grammar. A variety of literary devices, including metaphor, allegory, simile, humor, and puns, make reading enjoyable. This article describes the methods and procedures contained in Alaghar Killai Vidu Thootu.
Transformation of Payment in Education Use Bitcoin with Reduced Confirmation Times
Authors: Henderi  , Aini Qurotul , Manongga Danny , Sembiring Irwan , Apriliasari Dwi
Published: December 2022

Significant changes in the financial system are prompted by the growth of the national economy, particularly as a form of payment. The means evolved from barter to things or commodities to metal and paper as the base materials for money before arriving at barter. With such significant changes, there is also a need for a transformation in the world of education in order to welcome technological advancements and one way to survive the changes in the increasingly rapid digital era. As the economic need increases, trade transaction methods shift from traditional to internet-based. One of the necessary international online payment options is bitcoin. For many applications where payments are modest and instantaneous approval is required, Bitcoin is inappropriate because of the high transaction fees and long confirmation periods. As a result, despite the introduction of numerous rival cryptocurrencies to address these problems, the Bitcoin network continues to be the most extensively used payment method. Unquestionably, new finding of this research that effectively address the problems of high transaction costs and transaction verification times are needed if the company is to benefit from its user network. The Lightning Network (LN), which makes use of off-chain bidirectional payment channels between participants, is one of the most recent payment network concepts to be proposed.
SOCIO-PSYCHOLOGICAL ASPECTS OF INDIVIDUAL SOCIALIZATION
Authors: Сабиров Т.
Published: December 2022

The article deals with the problem of personality socialization and socio-psychological aspects that affect it. The relevance of scientific work is expressed in the problem of determining the phenomenon of personality, as well as the importance of analyzing the process of socialization in the context of the development of a healthy and successful personality. Human ontogenesis is considered in the context of certain age stages on the example of E. Erickson's age periodization. The categories of the subject of socialization and the object of socialization are described. The place of socialization as a system-functional mechanism of personality development is determined
PHILOSOPHICAL INITIATIVES IN KYRGYZ POETRY
Authors: Элебесова Б.
Published: December 2022

In Kyrgyz poetry, poems devoted to immortal themes are created in a philosophical atmosphere and contribute to the treasury of poetry. Death and life, love and hate, hope and fear, and so on. In the poetry of poets who are trying to understand the essence of phenomena and explain them more broadly, in a more general way, the content of philosophical thought seems clear and makes readers think. Therefore, philosophical motives about a person should be considered within the framework of the general work of the poet, based on his artistic thinking. The fact is that Kyrgyz poetry has developed its own traditions of philosophical consideration of human nature, and the next generation of poets, not only in national literature, but also in world poetry, sought to convey the spark of human nature in philosophical images.
THE NOTION OF “PUNCTUALITY” IN ENGLISH AND KYRGYZ LINGUISTIC VIEW OF THE WORLD
Authors: Туйтеева Н.
Published: December 2022

The significance of the completed article lies in the fact that its results can be used in theoretical courses in English lexicology, stylistics and text interpretation, in special courses on linguistic culturology and intercultural communication, as well as in classes in English and Kyrgyz as foreign languages. In connection with a new stage in the development of closer economic, cultural and social relations between our country and the world community, the need arose for a slightly different attitude to the study of English and Kyrgyz as a connecting link of interethnic communication. The significance of this article lies in the fact that it answers the most pressing questions, the solution of which will allow more practical and rational training of specialists who not only understand the language, but also speak it at a higher level, which will allow them to be correctly understood during business presentations or other negotiations at various levels.
THE TRADİTİON OF WEARİNG EARRİNGS İN KYRGYZ CULTURE
Authors: Cengiz Buyar , Feray OFLAZ
Published: December 2022

The Kyrgyz, one of the oldest tribes known in history. The Kyrgyz, who have this deep-rooted to their traditions and customs. Birth, marriage and death are important periods in life. There are ceremonies practiced in the marriage process in the world. However, the ceremonies differ from society to society. Many traditions have been formed around these ceremonies. These ceremonies are very rich in terms of culture among the Kyrgyz. In the study, the soyko saluu, the earring wearing ceremony, which is included in the marriage ceremonies of the Kyrgyz, is discussed. Kyrgyz wedding ceremonies are tried to be revealed.
TEACHING ADJECTIVES AT ENGLISH CLASSES
Authors: Турусбекова А. , Касмалиева Э.
Published: December 2022

This article discusses the importance and ways of teaching adjectives at the English lessons. Adjectives are one of the most important parts of speech in grammar. By their expressive characteristics, adjectives occupy one of the leading positions among other parts of speech. Written and spoken language become expressive, detailed and informative due to adjectives. The use of various methods and approaches in teaching adjectives in English lessons is a requirement of modern methodology. The communicative technique involves active speaking, working with oral speech with the help of various exercises. The article also offers a number of exercises and games for the development of vocabulary and communicative competence of students when learning adjectives in the English language. These speaking and language tasks are a kind of foundation, the basis for the development of oral speech skills, a means of developing the grammatical side of speech, without which it is impossible to imagine correct oral speech.
ETHNOPEDAGOGY AND ANALYSIS OF LITERARY WORKS IN SENIOR GRADES
Authors: Кенжешев К.
Published: December 2022

This article examines the analysis of a literary work to address issues necessary for the development of a range of competencies in Kyrgyz literature in senior grade students. Its connection with ethno-pedagogy will be revealed during the analysis of the art work. What situations are taken into account when connecting the problem to Kyrgyz literary works depends on the content of the lesson. Competent analysis of literary works will increase the level of ethno-pedagogical education of students. Scientific and methodological development of the topics of Kyrgyz literature reveals to the students that ethno-pedagogical content is a social problem of cognition. Examples show that literary education is not taken into account in secondary school. It is interpreted on the basis of students' personal, socio-cultural competencies.
VIEWS OF THE NOTION IN THE SCIENTIFIC LITERATURE
Authors: Туйтеева Н.
Published: December 2022

The term concept is sometimes considered equivalent to the term notion, because the word concept is etymologically derived from the Latin word conceptus, which means notion. Due to the large number of different analyzes being interpreted, different opinions have been born among researchers about the meaning of the term "concept". Initially, the term "concept" was synonymous with the word "понятие". In connection with a new stage in the development of closer economic, cultural and social relations between our country and the world community, the need arose for a slightly different attitude to the study of English and Kyrgyz as a connecting link of interethnic communication. The significance of this article lies in the fact that it answers the most pressing questions, the solution of which will allow more practical and rational training of specialists who not only understand the language, but also speak it at a higher level, which will allow them to be correctly understood during business presentations or other negotiations at various levels.
The Effectiveness of Ginger Oil Aromatherapy and Lemon Oil Aromatherapy on Reducing Emesis Gravidarum in Pregnant Women
Authors: Yonni Siwi Retno Palupi , Erma Retnaningtyas  , Anggrawati Wulandari  , Laily Dwi Jayati
Published: December 2022

Emesis Gravidarum is caused by changes in liver glycogen and an increase in the hormone HCG. The purpose of this study was to determine the difference in the effectiveness of ginger oil aromatherapy and lemon oil aromatherapy on the reduction of emesis gravidarum in pregnant women. The design in this study is a quasy experiment with two groups of pretest posttest design with a sample size of 15 respondents per group. The sampling technique uses Simple Random Sampling while the data analysis test uses the Wilcoxon and Mann Whitney test. Before being given Ginger Oil aromatherapy as many as 9 respondents experienced moderate emesis. After being given ginger oil aromatherapy, 8 respondents did not experience emesis. Before being given Lemon Oil aromatherapy 9 respondents experienced mild emesis. After being given Lemon oil aromatherapy 12 respondents did not experience emesis. Analysis of the Wilcoxon test results there is an effect of giving Ginger Oil and Lemon Oil aromatherapy to reduce emesis gravidarum and the Mann Whitney test it is that Ginger Oil Aromatherapy is more effective in reducing nausea and vomiting compared to Aromatherapy Lemon Oil. Ginger oil contains essential oils that can be used to reduce nausea in pregnant women because the aroma produced is stronger.
Z Kuşağının Öğretmenlerinde Bulunması Gereken Yeterlilikler: Bir Durum Çalışması
Authors: ŞAHİN Ayfer , ASAL ÖZKAN Rabia , TURAN Büşra Nur
Published: December 2022

Bu çalışmanın amacı; Z kuşağına öğretmenlik yapacak sınıf öğretmenin sahip olması gereken yeterliliklerin sınıf öğretmeni, öğrenci ve veli görüşleri ile belirlemektir. Çalışmada; nitel araştırma yöntemlerinden durum çalışması kullanılmıştır. Araştırmanın çalışma grubunu Kayseri ilinde yaşayan 30 sınıf öğretmeni, 30 ilkokul öğrencisi ve 30 öğrenci velisi oluşturmaktadır. Araştırmada veriler araştırmacı tarafından geliştirilen yarı yapılandırılmış görüşme formu aracılığıyla toplanmıştır. Elde edilen veriler içerik analizine başvurularak analiz edilmiştir. Araştırma sonuçlarına göre; sınıf öğretmenlerine göre z kuşağına öğretmenlik yapan sınıf öğretmenlerinde bulunması gereken en önemli mesleki yeterlilik; öğretmenlik mesleğini ve çocukları sevmek, yenilik ve değişimlere açık olmak, güncel olayları takip etmek, sınıf yönetiminde başarılı olmaktır. İlkokul öğrencilerine göre z kuşağına öğretmenlik yapan sınıf öğretmenlerinde bulunması gereken en önemli alan bilgisi yeterlilikleri; teknoloji etkili kullanmak ve yeterli alan bilgisine sahip olmaktır. Velilere göre ise z kuşağına öğretmenlik yapan sınıf öğretmenlerinde bulunması gereken en önemli kişisel yeterlilikler; yaratıcı ve adaletli olmaktır. Çalışmadan ulaşılan sonuçlara göre; öğretmenlerin hızla gelişen ve değişen dünyaya ayak uydurabilmeleri için mesleki gelişimlerini destekleyecek eğitimler (STEM, robotik kodlama, dijital oyun vb.) düzenlenmesi önerilmiştir.