bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention
Authors: Antonijevic Nebojsa , Mitrovic Predrag , Gosnjic Nikola , Orlic Dejan , Kadija Sasa , Ilic Mostic Tanja , Savic Nebojsa , Birovljev Ljubica , Lekovic Zaklina , Matic Dragan
Published: August 2023

Cesarean section is a challenge intervention in patients treated with dual antiplatelet therapy. We present case of 32 years old pregnant woman experiencing large acute myocardial infarction (MI) of anterolateral wall complicated by cardiogenic shock in the 38th week of pregnancy treated with drug-eluting stent implantation and dual antiplatelet therapy (DAPT) consisting of aspirin and ticagrelor. Less than 24 hours after MI delivery started, urgent Caesarean section was indicated. As multiplate aggregometry testing showed a relatively insufficient level of ticagrelor platelet inhibition and a moderate level of aspirin platelet inhibition, Caesarean section was performed without discontinuation of ticagrelor, which was decided due to the need for emergency surgery. Local hemostatic measures including administration of tranexamic acid were applied. The patient did not experience excessive bleeding. A healthy male baby was born. To the best of our knowledge, this is the first reported case of surgery in pregnant women treated with DAPT without ticagrelor discontinuation.
Use of Apolipoprotein B in the Era of Precision Medicine: Time for a paradigm change?
Authors: Cole Justine , Zubirán Rafael , Wolska Anna , Jialal Ishwarlal , Remaley Alan T
Published: August 2023

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and the risk of a major cardiovascular event is highest among those with established disease. Ongoing management of these patients relies on the accurate assessment of their response to any prescribed therapy, and their residual risk, in order to optimize treatment. Recent international guidelines and position statements concur that the plasma concentration of apolipoprotein B (apoB) is the most accurate measure of lipoprotein associated ASCVD risk. This is especially true for the growing number of individuals with diabetes, obesity or the metabolic syndrome, and those on statin therapy. Most guidelines, however, continue to promote LDL-C as the primary risk marker due to uncertainty as to whether the greater accuracy of apoB is sufficient to warrant a paradigm shift. Recommendations regarding apoB measurement vary, and the information provided on how to interpret apoB results is sometimes insufficient, particularly for the non-lipid specialist. Misinformation regarding the reliability of the assays is also frequently repeated despite its equivalent or better standardization than many other diagnostic assays. Thus, demand for apoB testing is relatively low, which means there is little incentive to increase its availability or reduce its cost. In this review, we examine the results of recent clinical outcomes studies and meta-analyses on the relative values of apoB, LDL-C and non-HDL-C as markers of ASCVD risk. Although there is seemingly minimal difference among these markers when only population-based metrics are considered, it is evident from our analysis that, from a personalized or precision medicine standpoint, a great many individuals would benefit, at a negligible total cost, if apoB measurement were better integrated into the diagnosis and treatment of ASCVD.
Towards Feasible Solutions for Load Monitoring in Quebec Residences
Authors: Hosseini Sayed Saeed , Delcroix Benoit , Henao Nilson , Agbossou Kodjo , Kelouwani Sousso
Published: August 2023

For many years, energy monitoring at the most disaggregate level has been mainly sought through the idea of Non-Intrusive Load Monitoring (NILM). Nevertheless, a practical application of this concept in the residential sector should address the underlying concerns raised by the technical specifications of case studies. From one side, such an operation must handle common matters related to the essence of any NILM system. Although this aspect has been thoroughly investigated by basic research, it is limited to the properties of public datasets. On the other side, it must deal with specific concerns corresponding to uncommon situations. These circumstances impose further restrictions on existent NILM schemes, however, they have been overlooked due to the lack of pertinent databases to scrutinize. Accordingly, this paper presents applied research on a potential solution to NILM for Quebec residences. It carries out a relevant investigation into the multi-faceted nature of this problem in order to reveal barriers to feasible implementations in the context of Quebec. This work commences with a concise discussion about the NILM idea to highlight its essential requirements for a fruitful practice. Afterward, it provides a comparative statistical analysis to represent the specificity and potential challenges of the case study in accordance with NILM necessities. For this purpose, the examination exploits data from real-world measurement systems in the same and European regions. Subsequently, this study focuses on a load identification exercise by proposing a combinatory approach that utilizes the promise of sub-meter smart technologies to integrate the intrusive aspect of load monitoring with the non-intrusive one. The former is aimed at extracting overall heating demand from the aggregate one by a supervised procedure based on Deep Learning (DL) models while the latter is designed for disaggregating the residual load through an unsupervised process on the basis of clustering techniques. The results demonstrate that geographically-dependent cases create electricity consumption scenarios under which existing NILM methods can be questioned. From a realistic standpoint, this research elaborates on critical remarks to realize viable NILM systems, particularly, in Quebec houses.
Accessibility and Inclusiveness of New Information and Communication Technologies for Disabled Users and Content Creators in the Metaverse
Authors: Radanliev Petar , De Roure David , Novitzky Peter , Sluganovic Ivo
Published: August 2023

Despite the proliferation of Blockchain Metaverse projects, the inclusion of physically disabled individuals in the Metaverse remains distant, with limited standards and regulations in place. However, the article proposes a concept of the Metaverse that leverages emerging technologies, such as Virtual and Augmented Reality, and the Internet of Things, to enable greater engagement of disabled creatives. This approach aims to enhance inclusiveness in the Metaverse landscape. Based on the findings, the paper concludes that the active involvement of physically disabled individuals in the design and development of Metaverse platforms is crucial for promoting inclusivity. The proposed framework for accessibility and inclusiveness in Virtual, Augmented, and Mixed realities of decentralised Metaverses provides a basis for the meaningful participation of disabled creatives. The article emphasises the importance of addressing the mechanisms for art production by individuals with disabilities in the emerging Metaverse landscape. Additionally, it highlights the need for further research and collaboration to establish standards and regulations that facilitate the inclusion of physically disabled individuals in Metaverse projects.
Aboveground Biomass Mapping and Fire Potential Severity Assessment: A Case Study for Eucalypts and Shrubland Areas in the Centre Inland of Portugal
Authors: Alegria Cristina
Published: August 2023

Shrubland and forestland covers are highly prone to fire. The Normalized Difference Vegetation Index (NDVI) has been widely used for biomass quantitative assessment. This study aims were the following: (1) to compute the NDVI annual curve for two types of land cover eucalypts and shrubland areas; (2) to collect field data in these two types of land cover to estimate aboveground biomass (AGB); and (3) to produce AGB maps for eucalypts and shrubland areas by modelling AGB with NDVI and validate them with other data sources. A study area in the central inland Portugal was considered. The Sentinel-2 MSI imagery for the year of 2022 and 2023 were used to compute the NDVI. The NDVI annual curve for 2022 showed a minimum observed between July and August, in accordance with the climatological data, and allowed differentiating eucalypts from shrubland areas. Spectral signatures also confirmed this differentiation. The fitted linear models for AGB prediction using the NDVI imagery showed good fitting performances (R2 of 0.76 and 0.69). The AGB maps provide a relevant decision support tool for forest management and for fire hazard and fire severity mitigation. Further research is needed using more robust data sets for models’ independent validation.
Simulation Study on the Process of Cleaning Oily Sludge with High-speed Stirring Rotor
Authors: Wang Yin , Li Keqing , Zhao Jiao , Tang Xiaojia , Li Tie , Liu Xianmeng , Zhang Hao , Zhu Yimin
Published: August 2023

In this paper, COMSOL Multiphysics software was used to simulate and analyze the process of cleaning oily sludge by high-speed stirring rotor. The physical phenomena such as velocity field, pressure field, heat dissipation and cavitation generated by the rotor during the process of the oily sludge cleaning were analyzed. The results showed that in the process of cleaning the oily sludge by high-speed stirring rotor, the shear force, heat dissipation and pressure increased with the enhance in the rotor speed. Cavitation occurs in the impeller area of the rotor because of the change of pressure, so the cavitation bubbles were formed. Shear force, heat dissipation and cavitation contributed to the separation of oil phase in oily sludge. Meanwhile, the simulation results were verified by experiments.
Hyperparameter Optimization of CNN Using DBO for Speaker Recognition
Authors: Guo Xinhua , Qin Xiao , Zhang Qing , Zhang Yuanhuai , Wang Pan , Fan Zhun
Published: August 2023

Speaker recognition methods based on convolutional neural networks (CNN) have been widely used in the security field and smart wearable devices. However, the traditional CNN has a large number of hyperparameters that are difficult to be determined, which makes the model easy to fall into local optimum or even fail to converge during the training process. Intelligent algorithms such as particle swarm optimization and genetic algorithm are used to solve the above problems. However, these algorithms have poor performance compared with the current emerging meta-heuristic algorithms. In this study, the dung beetle optimized convolution neural network (DBO-CNN) is proposed to identify the speakers, which is helpful in finding suitable hyperparameters for training. By testing the dataset of 50 people, it was demonstrated that the accuracy of the model was significantly improved by using this approach. Compared with the traditional CNN and CNN optimized by other intelligent algorithms, the accuracy of DBO-CNN has increased by 0.6%~4.8%, and reached 98.3%.
Breeding Substrate Containing Distillation Residues of Mediterranean Medicinal Aromatic Plants Modulates the Effects of Tenebrio molitor as Fishmeal Substitute on Blood Signal Transduction and WBC Activation of Gilthead Seabream (Sparus aurata)
Authors: Antonopoulou Efthimia , Kolygas Markos , Panteli Nikolas , Gouva Evangelia , Kontogeorgiou Panagiota , Feidantsis Konstantinos , Chatzopoulos Achileas , Bitchava Konstantina , Zacharis Christos , Bonos Eleftherios , Giannenas Ιlias , Skoufos Ioannis , Andreadis Stefanos S. , Skoulakis Georgios , Athanassiou Christos G. , Nathanailides Cosmas
Published: August 2023

This work assesses the dietary use of two insect meals of Tenebrio molitor (TM) larvae reared in conventional (TM-10) or MAPs-enriched substrates (MAP-TM-10) as fish meal replacements (10%) in the diets of gilthead seabream (Sparus aurata). Fish (n=4,500; 207.19 ± 1.47 g) were divided into three groups with triplicates: Control (fed conventional diet), TM-10 and MAP-TM-10 groups.The fish were reared in floating cages for 12 weeks and The dietary effects on white blood cell ac-tivation, heat shock proteins, MAPKs, and apoptosis of the fish were evaluated. The MAP-TM-10 group exhibited the highest eosinophilic induction and plasma cells. Phosphorylated levels of p38 MAPK; p44/42 MAPK; HSP70 and HSP90 increased in the TM-10 and MAP-TM-10. In terms of apoptosis, Bax levels were lower in the TM groups compared to the Control, and the MAP-TM-10 group showed even lower levels than the TM-10 group. Bcl-2 levels increased in the TM-10 compared to the Control, and further increased in the MAP-TM-10 group. The Bax/Bcl-2 ratio, an apoptosis indicator, decreased in the TM groups, with the MAP-TM-10 group showing a further decrease compared to TM-10. These findings suggest that insects breeding substrate enriched with MAPs modulated the effect of TM on cellular stress and apoptosis.
Improving the Luminescence Performance of Monolayers MoS2 by Doping Multiple Metal Elements with CVT Method
Authors: Zhao Bojin , Huo Zongju , Li Lujie , Liu Hongjun , Hu Zhanggui , Wu Yicheng , Qiu Hailong
Published: August 2023

Two-dimensional (2D) transition metal dichalcogenides (TMDCs) draw much attention as critical semiconductor materials for 2D, optoelectronic, and spin electronic devices. Although controlled doping of 2D semiconductors can also be used to tune their bandgap and type of carrier and further change their electronic, optical, and catalytic properties, it remains an ongoing challenge. Here, we successfully doped a series of metal elements (including Hf, Zr, Gd, Dy) into the monolayers MoS2 through a single-step chemical vapor transport (CVT), and the atomic embedded structure is confirmed by scanning transmission electron microscope (STEM) with a probe corrector measurement. In addition, the host crystal is well preserved, and no random atomic aggregation is observed. More importantly, adjusting the band structure of MoS2 enhanced fluorescence and carrier effect. This work provides a growth method for doping nonlike elements into 2D MoS2 and potentially many other 2D materials to modify their properties.
LASSO and Elastic Net Tend to Over-Select Features
Authors: Liu Lu , Gao Junheng , Beasley George , Jung Sin-Ho
Published: August 2023

Machine learning methods have been a standard approach to select features that are associated with an outcome and build a prediction model when the number of candidate features is large. LASSO has been one of the most popular approaches to this end. LASSO approach selects features with large regression estimates, rather than based on statistical significance, associating the outcome, by imposing L1-norm penalty to overcome the high dimensionality of the candidate features. As a result, LASSO may select insignificant features while possibly missing significant ones. Furthermore, from our experience, LASSO has been found to select too many features. By selecting features that are not associated with the outcome, we may have to spend more cost to collect and manage them in the future use of a fitted prediction model. Using the combination of L1- and L2-norm penalties, elastic net (EN) tends to select more features than LASSO. The overly selected features that are not associated with the outcome act like white noise, so that the fitted prediction model loses the prediction accuracy. In this paper, we propose to use the standard regression methods (without any penalizing approach) with stepwise variable selection procedure to overcome these issues. Unlike LASSO and EN, this method selects features based on statistical significance. Through extensive simulations, we show that this maximum likelihood estimation based method selects very small number of features while maintaining a high prediction power, while LASSO and EN make a large number of false selections to result in loss of prediction accuracy. Contrary to LASSO and EN, the regression methods combined with a stepwise variable selection method is a standard statistical method, so that any biostatistician can use it to analyze high dimensional data even without advanced bioinformatics knowledge.
A Rare Location of Osteosarcoma in the Cuboid Bone
Authors: Dhillon Nireet , Vijayakumar Gayathri , Tepper Sarah C. , Braun Ankica , Blank Alan T.
Published: August 2023

Case:

In this case report, we describe a patient with left foot pain whose magnetic resonance imaging revealed a destructive tumor of the left cuboid bone. A biopsy of the tumor confirmed an osteoblastic osteosarcoma of the cuboid, and the patient was treated with chemotherapy followed by a below-the-knee amputation.

Conclusion:

There are only a handful of cases reporting osteosarcoma of the cuboid bone, and challenges remain in properly diagnosing the lesion to recommend the best course of treatment.
Strengthening Consumer Experience In Digital Economy Development
Authors: Jinus Yuliana Cintya , Burhanudin Burhanudin
Published: August 2023

The development of the digital economy requires strengthening the consumer experience. This research was conducted by examining the relationship between digital economy security when shopping on ecommerce, output quality, customer utility, and the intention to recommend ecommerce to others. The survey was conducted at one of the ecommerce sites in Indonesia, namely Shopee, to test the above relationship and as many as 225 Shopee consumers were involved in the survey. The data collection method used in the study was to distribute questionnaires directly to the respondents. The collected data was then analyzed with a structural equation model. The results of the analysis show that digital economy security when shopping on ecommerce and output quality has a positive and significant effect on customer utility. Furthermore, customer utility has a significant positive effect on consumer recommendations. The results of this analysis indicate that ecommerce must always maintain transaction security and the quality of the output offered so as to provide utility to customers. This utility is important for the development of ecommerce because it encourages customers to recommend the ecommerce to other consumers.
The Impact Of Nusa Data Prima Corner Wifi In Improving Community Economy Based On Maqashid Syari'ah
Authors: Sulistyowati Sulistyowati , Yasin Achmad , Zarkoni Achmad
Published: August 2023

The rapid development of technology has influenced the behavior of human life, including the economic aspect. The current shift in economic transactions is more or less shifting from offline to online so that it affects the economic activities of the community which are also growing and expanding. That is why, nowadays internet access is not only needed in urban areas, but also important for rural communities, especially to improve the economic level of their people. This study examines the Impact of Nusa Data Prima Wifi Corner on Economic Improvement and the Impact of using Nusa Data Prima Wifi Corner on Community Economic Improvement in terms of Maqasid Syariah. The qualitative method in this study was carried out through interviews, then documenting the data found, and making observations in the field. This research resulted in the following conclusions: (1) The impact of the wifi corner is an increase in the economy where residents who previously only relied on income from plantation and agricultural products now have other income, both from online sales and from other business results such as buying and selling stocks and brokers buying and selling cars and others, some residents who become partners in the sale of vouchers also benefit from the sale of these vouchers. (2) Judging from the theory of maqashid syari'ah the impact of the existence of Wifi Corner is a form of benefiting dhoruriyah, hajiyyah and tahsiniyah.
Factor Analysis of Demand for Kaligua Tourism in Brebes Regency: A Case Study Using Primary Data
Authors: Hawa Sarah Dien , Syauqi Ahmad , Rolisnawati Rolisnawati , Akbar Haydar Za'im
Published: August 2023

Based on BPS data, Kaligua tourism experienced a decrease in visitors in 2020 of 68,110 people, down to 64,325 in 2021. And it will drop again in 2022 to 51,587. This indicates a decrease in income for Kaligua tourism objects even though this sector is very important because it has a role in the economy. Against the backdrop of the current problems, it appears that the tourism sector plays a very important role in economic growth, and the growth of new tourist destinations has led to increasingly fierce competition between tourist sites to attract tourists to visit. On the other hand, services in tourism management in terms of serving tourists are not yet good. The purpose of this research is to develop a strategy that can increase the number of tourist visits in Kaligua tourism. Kaligua Tourism continues to experience a decline in visitors from 2020 to 2022, so research is needed to formulate the right strategy to increase visitors to Kali Cave tourism. This research was conducted to determine the effect of penetration pricing and consumer motivation on the decision to visit Kaligua tourism. Data were obtained through interviews. 97 Respondents who have already visited Kaligua tourism will be asked to fill out a questionnaire, and the results will be tested through smart PLS. It is hoped that this research will be able to become the basis and reference for Kaligua tourism in determining the right strategy to increase Kaligua tourism visitors.
APVC2021 - Low frequency and broadband vibration and sound radiation reduction of panels from high performance metamaterial damping
Authors: Song Yubao , Chen Shengbing , Zhang Hao , Fan Zhenglei , Peng Qian
Published: August 2023

The low frequency and broadband reduction of vibration and sound from damping treatment is one of the major concerns in research and engineering. In this paper, the combination of artificial metamaterial and damping design is used to improve the reduction effect. The vibration and sound radiation properties of the bare, free layered damping and metamaterial damping panels are compared and studied. Via the comparison of various panels, the vibration and sound radiation reduction and the enhancement from metamaterial damping are analysed. The effects of the material parameters of metamaterial damping elements are studied also. The numerical results indicate that the vibration reduction is significantly improved from the metamaterial damping in quite wide frequency ranges from low to high frequencies; the sound radiation is suppressed effectively also, especially the peaks are reduced obviously. A better reduction effect can be obtained via metamaterial design even with the same added mass as traditional damping treatment, especially, at the middle to low frequencies. The effects from the material parameters of metamaterial damping design are different from those of free layered damping design. And the manipulation and control of the damping effects from metamaterial design will be flexible and easy to realize. Further, an experimental system is built, and the experimental study and verification are carried out. The significant reduction and obvious enhancement from metamaterial damping design are observed from the experimental results.
Assessment of Co-digestion From Poultry Litter and Swine Wastewater and Enrichment Inoculum Effect in Biogas Production
Authors: Somer Juliana Gaio , Luiz Franciele Natividade , Marteres Tiago Joelzer , Meyer Rafaela Faust , Bernal Suzan Prado Fernandes , Passarini Michel Rodrigo Zambrano , Boroski Marcela
Published: August 2023

Lignocellulosic substrate co-digestion as a pre-treatment step to anaerobic digestion increases the viability of using agro-industry waste for biogas production. This study aimed to assess proportions of co-digestion of swine manure and poultry litter for greater methane production, in addition to analyzing the effect of microbial inoculum enrichment on biodigestion. After co-digestions were prepared, the fractions (solid and liquid) were separated, and the liquid was used in the tests. Methane production potential tests were assessed using the Doehlert experimental design in co-digestions of swine manure and poultry litter at 0%, 10%, 20%, 30% and 40% (m/m). The other variable studied was the amount of inoculum added (ISR) at levels of 2, 1.25 and 0.5. The highest methane production values (286–284 NL kgVS-1) were obtained in co-digestions between 10% and 20% (m/m) of poultry litter, which present total solids compatible with using covered lagoon and CSTR model biodigesters. A 34% increase was obtained in the microbial inoculum enrichment study, when compared to standard inoculum use. The co-digestion phase separation procedure developed in this study increased the feasibility of implementing this technology as an alternative to biogas production in commonly used biodigestion systems.
Experiences and perceptions of respectful maternity care during childbirth in health facilities of Eastern province of Rwanda: An Appreciative Inquiry
Authors: Muhayimana Alice , Kearns Irene Josephine , Gishoma Darius , Tengera Olive , Uhawenimana Thierry Claudien
Published: August 2023

Introduction: The World Health Organization (WHO) emphasized the importance of positive childbirth experiences by treating mothers with respect and dignity. Unfortunately, instances of negative childbirth experiences have been documented in several countries,including Rwanda. By examining the best experiences and practices, it becomes possible to discover realistic and culturally accepted sustainable solutions within resource-limited settings such as Rwanda. The objective of this study was to investigate and describe how mothers in the Eastern province of Rwanda perceive and appreciate their own childbirth experiences in relation to RMC.Methods: We employed a qualitative, exploratory, descriptive, and contextual design to examine and describe mothers' positive experiences and perceptions regarding RMC of recent labor and childbirth. The sampling was purposive, focusing on mothers who reported being treated with respect during labor and childbirth in general. A total of 30 mothers were selected from five hospitals in the Eastern Province of Rwanda. To collect the data, we conducted in-depth interviews (IDIs) using questions of the 5D cycle of the Appreciative Inquiry (AI) method. Thematic analysis was employed, and NVivo 12 was utilized to organize the codes and create a codebook.Results: The three main themes and subthemes emerged; 1) Appreciated care encompassed compassionate care and emotional support, autonomy and self-determination, timely care, privacy and confidentiality preservation, and an enabling environment. 2) Perceived greatest care, which focused on respectful care meaning and happiness motives. 3) Suggested strategies, which involved women's self-control, providers' behaviors, and caring leadership.Conclusion: The findings revealed that appreciated care is crucial and integral to the entire birth process. We recommend comprehensive collaboration between services users, healthcare providers (HCPs) and health care management. These measures will help to maintain and reinforce the positive aspects associated with RMC, as reported by the mothers. Furthermore, due to the sensitive nature of RMC, we suggest conducting further studies utilizing the AI approach.
Clinical characteristics and response to abatacept of three Mexican patients with LRBA deficiency
Authors: Eduardo Liquidano-Perez , Ramirez-Ristori Alfonso , Daniela Perez-Perez , Carolina Moreno-Corona Nidia , Eduardo Carrillo-Tapia , Laura Vazquez-Carrillo , Leopoldo Santos-Argumedo , Carlos Rodriguez-Alba Juan , Carlos Bustamante-Ogando Juan , Selma Scheffler-Mendoza , Javier Espinosa-Rosales Francisco , Fabiola Mújica-Guzman , Edith Gonzalez-Serrano Maria , Antonio Yamazaki-Nakashimada Marco , Elva Espinosa-Padilla Sara , Lopez-Herrera Gabriela
Published: August 2023

Purpose. To describe the genetic and clinical characteristics of three patients with LRBA deficiency, an inborn error or immunity that has not been described previously in Latin American patients. Methods. This study included three pediatric patients with recurrent infections, hypogammaglobulinemia, thrombocytopenia, lymphopenia, and pulmonary and gastrointestinal effects. Exome sequencing was performed, variants in LRBA were confirmed by Sanger sequencing, and segregation was investigated to confirm the occurrence of compound heterozygous variants in two patients. LRBA detection in activated PBMCs was performed for all patients, and immunoglobulin levels and cell populations were determined. Clinical records for patients were consulted to determine the type of infection, lung and colon biopsy results and the response to immunosuppressive treatment, including abatacept. Results. Two of the three patients showed an early onset of manifestations. Two patients carried compound heterozygous genetic variants in LRBA, and one patient carried a homozygous variant. Of the five variants identified, three of them were novel and caused a loss of LRBA expression in two of the patients. The three patients presented lung damage and bowel disease. They showed lymphopenia and/or thrombocytopenia. Biopsy sample analysis showed lung or colon damage, and the colon mucosa showed polymorphonuclear infiltrates. Finally, two patients showed partial remission with abatacept; however, the patient with the largest protein truncation did not respond to abatacept treatment. Conclusion. The variants in LRBA reported in this manuscript are novel or were not previously associated with immunodeficiency. The patients whose cases are reported here showed a variable phenotype. The patient with the worst clinical phenotype had the largest protein truncation.
Primary Vs. Staged Repair for Low Anorectal Malformation: Outcome of Two Institutions Experience
Authors: Mirza Abdurrahman , Ullah Irfan , Banoon Elaf , Hakeem Anan , Almaary Jamila , Yousef Yasmin , Bamajboor Abdullah
Published: August 2023

Introduction:
Anorectal malformations (ARM) constitute one of the frequent congenital anomalies which are encountered in pediatric surgery in 1 in 5000 births. The defect affects the normal positioning of the anus, and a corrective surgical procedure is required for repositioning. Rectovestibular fistula is the most common form of ARM that is found in female infants. Posterior sagittal anorectoplasty (PSARP) without colostomy (single-stage) and Posterior sagittal anorectoplasty with colostomy (three-stages) has often been compared as the most feasible interventions to treat both rectovestibular and rectoperineal fistulae. The objective of this study was to assess the result of posterior anorectoplasty with or without diverting colostomy in patients with rectoperineal or rectovestibular fistulae.
Methodology:
A retrospective cohort study was undertaken to examine the post-operative outcomes of single-stage and three-stages PSARP on infants with rectovestibular and rectoperineal fistulae in Riyadh and Jeddah regions of Saudi Arabia. After ethical approvals from King Abdullah International Medical Research Centre, the study reviewed patient files from National Guard hospitals from the two regions.
Results:
Out of the 50 patients studied, 80% were females, while 20% were males. The most typical type of fistula was rectovestibular, which accounted for 54%, while rectoperineal accounted for 46%. PSARP without colostomy (single-stage) was the most common intervention. Major complications reported after the operations were constipation (44%), soiling (10%), wound infection (6%) and dehiscence (6%).
Conclusion:
The one-stage PSARP without colostomy has been identified as the feasible, safe, cost-effective surgical procedure to be used on ARM infants.
Establishment of the microstructure of porous materials and its relationship with effective mechanical properties
Authors: Chen Kangni , Qin Hongling , Ren Zhiying
Published: August 2023

In this study, a porous structure for a porous liquid storage medium is generated, and the homogenization theory based on displacement boundary conditions is used to predict the effective mechanical properties. The relationship between the porous material's macroscopic mechanical properties and microstructure is next analyzed. In order to establish the relationship between the microstructure of porous materials and their macroscopic mechanical properties, assuming that the pores grow along the z direction, a method is proposed to generate 3D open-cell porous materials based on six design parameters (i.e., the number of pores, porosity, irregularity of pore distribution, the randomness of pore growth in the x and y directions, and randomness of pore size). Since the porosity of oil-bearing materials ranges from 20–30%, the porosity of the RVE (Representative Volume Element) was kept under control at about 25%, and the effect of the six design factors on the mechanical properties of the RVE was investigated. Utilizing SLA 3D printing technology, specimens were produced, and compression tests were used to show how useful the results of the numerical analysis were. The results demonstrated that the mechanical properties of the models generated with the identical design parameters are similar whenever the number of RVE pores reaches 16 and the irregularity of the pore distribution reaches 0.25. The mechanical properties of porous materials simultaneously decrease in the z direction and increase in the x and y directions as the randomness of pore growth increases. Pore size randomness has a similar effect on RVE as pore growth randomness. However, the pore size's randomization can lead to instability in the RVE's porosity, which can lead to unstable mechanical properties. The mechanical properties of RVE are simultaneously affected by the design parameters, which are superimposed.
All dielectric highly efficient achromatic meta-lens using inverse Design Optimization
Authors: Maher Abdullah , Swillam Mohamed A.
Published: August 2023

This work presents a high-efficiency achromatic meta-lens based on inverse design with topology optimization methodology. The meta-lens design with high numerical aperture values (NA = 0.7, NA = 0.8, and NA = 0.9) along the visible band starts from 450 nm to 800 nm. The final optimized structures for the three conditions of the high numerical apertures have high focusing efficiency along the design band. The optimization problem is based on Kreisselmeier–Steinhauser (k-s) objective function, leading to approximately stable response over the broadband bandwidths of the three designs.
Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence
Authors: Wu Linxu , Zhu Xinglin , Luo Cai , Zhao Yangyang , Pan Shanshan , Shi Kaijia , Shen Zhihua , Guo Junli , Jie Wei
Published: August 2023

Objective: Hyperinflammatory responses are pivotal in the pathophysiology of cardiomyocyte senescence, with IL33 serving as a crucial pro-inflammatory mediator. Our previous findings highlighted RND3's suppressive effect on IL33 expression. This study delves into the influence of RND3 on IL33/ST2 signaling activation and cardiomyocyte senescence.
METHODS: AC16 cardiomyocytes were subjected to treatments involving recombinant IL33, NF-κB inhibitor PDTC, or ST2 antibody Astegolimab. SA-β-gal and γH2AX staining were utilized to monitor alterations in cell senescence and DNA damage, respectively. Western blot analysis was conducted to ascertain the expression of Senescence-Associated Secretory Phenotype (SASP) and NF-κB activation. Utilizing CRISPR/Cas9 technology, the RND3 gene was knocked out in H9C2 cells, followed by senescence analysis and sST2 level detection in the culture medium supernatant via ELISA. Post-AAV9 injection overexpressing RND3in SD rats, IL33/ST2 and SASP expression in heart tissues, and serum IL33 and sST2 changes were evaluated using ELISA.
RESULTS: Exogenous IL-33 significantly induced IL-1α, IL6, and MCP1 expression, increased the p-p65/p65 ratio, and the proportion of SA-β-gal and γH2AX positive cells in AC16 cells. PDTC and Astegolimab application mitigated these effects. RND3 knockout in H9C2 cells led to increased intracellular IL33, ST2L, IL1 α, IL6, and MCP1 expression, decreased sST2 in the supernatant, and increased SA-β-gal and γH2AX positive cells. RND3 overexpression suppressed IL33, ST2L, IL-1α, IL6, and MCP1 expression in heart tissues, decreased serum IL33, and increased sST2 levels.
CONCLUSION: RND3 expression in cardiomyocytes modulates cell senescence by negatively regulating the IL33/ST2/NF-κB signaling pathway, underscoring its potential as a therapeutic target in cardiovascular senescence.
Biological treatment with co-inoculation of Pseudomonas fluorescens and Trichoderma viride as effective method for degradation of chlorpyrifos in soil
Authors: Arya P. R. , Binitha N. K , Unnikrishnan Boby Vattekkattu
Published: August 2023

A study conducted to understand chlorpyrifos degradation revealed that content of chlorpyrifos was reduced by 34.76% within 60 days of incubation under natural conditions. Effect of physical, chemical and biological treatments on fastening the process of chlorpyrifos degradation was evaluated, which revealed that biological treatment with microbial inoculants (combination of Pseudomonas fluorescens and Trichoderma viride) recorded maximum degradation (74.99%) followed by single application of Pseudomonas fluorescens (69.94%) and Trichoderma viride (66.35%) on 60 days of incubation. Soil enzymes: dehydrogenase, phosphatase and urease showed significantly higher activities in treatments with Pseudomonas fluorescens and Trichoderma viride either single or combination on comparison with control. Microbial biomass carbon increased to 99.16 µg g− 1 in treatment receiving combination of Pseudomonas fluorescens and Trichoderma viride while control recorded only 83.77 µg g− 1. Co-inoculation of Pseudomonas fluorescens and Trichoderma viride resulted in faster degradation of chlorpyrifos without affecting the chemical and biological properties of soil.
The Significance of Preoperative Systemic Immune Inflammation Index in Newly Diagnosed Glioblastoma Patients and the Establishment of a Nomogram
Authors: Xu Hao , Jiang Lihao , Yu Shengnan , Ren Qinglan
Published: August 2023

Purpose
The systemic immune inflammation index (SII) has acquired prominence as a cancer patient prognostic factor and has been utilized as an essential biomarker. Many malignant tumors' prognoses are correlated with SII, and its function in glioblastoma (GBM) is unclear. In this investigation, we sought to determine the prognostic value of SII in newly diagnosed GBM and to develop a nomogram in accordance with these findings.
Methods
The information of patients with newly operable GBM was analyzed. We identified the statistically ideal threshold values for cancer-specific death with the highest sensitivity and specificity based on Receiver Operating Characteristic Curve. To account for any potential imbalance in confounding factors, Propensity Score Matching (PSM) was utilized. Based on the findings, a nomogram was developed. The performance of the nomograms in terms of calibration, discrimination, and clinical utility was evaluated.
Results
We performed a retrospective analysis on 109 patients newly diagnosed with GBM. A lower preoperative SII (SII≤610.13) was associated with considerably longer overall survival (OS) in GBM patients, as shown by the Kaplan-Meier analysis of survival (p = 0.045). In GBM patients, using a multivariate Cox proportional hazard model, SII was found to be an independent risk factor for OS (HR=0.030, 95% CI=1.060-3.000, P=0.05). The prognosis of GBM patients could be accurately predicted using a nomogram that included SII.
Conclusion
Preoperative SII level was an independent prognostic factor for GBM patients. The nomogram including SII underscored its significance. However, further evaluation and future research are needed to validate these findings.
Synthesis and characterization of PCC from marble waste for its application in papermaking
Authors: Dhakad Vinod Kumar , Shrivastava Prashant , Agarwal Saakshy , Jana Susanta Kumar
Published: August 2023

CaCl2 solution and Ca(OH)2 slurry, both prepared from marble waste (MARWAS), were carbonated with CO2 gas in the presence of CTAB, SDS, Teepol-610s, Triton-X, and Tween-80 as the surface modifiers in a semi-batch foam-bed reactor (FBR) to synthesize ultrafine or submicron PCC particles with enhanced hydrophobicity. Nano/ultrafine PPC particles with and without surfactant were also synthesized in a semi-batch stirrer reactor (SR) using CaCl2 solutions made from MARWAS and NH4HCO3 as the carbonating agent by single or simultaneous application of ultrasonication (US) and surfactant, respectively. The products were characterized by SEM, TEM, XRD, FTIR, and drop shape analyzer. In the presence of SDS in the FBR, distinct and smaller hydrophobic (water contact angle of 103.3o) vaterite particles (426 nm) could be produced using CaCl2 solution than those with the Ca(OH)2 slurry. However, in the SR, methanol was found to be more effective than the aqueous solvent in synthesizing needle-like aragonite nanoparticles (215.6 nm with L/D = 8.55) from CaCl2 solution without any use of US or surfactant. Handmade papers were manufactured using ground MARWAS powder, modified and unmodified PCC. The physical, mechanical, and optical properties of these filler-loaded papers were determined. The use of surface-modified and unmodified PCC was superior to the commercial PCC in increasing filler retention, burst strength, tear strength, brightness, and opacity of the paper hand sheets. Even the direct use of MARWAS powder was found to be more effective than GCC in enhancing the optical properties, although a slight decrease in the mechanical strength was observed.
THE MAKING OF SINGLE PARENT RESILIENCE IN POST-COVID-19 PANDEMIC IN INDONESIA
Authors: Anshor Ahmad Muhtadi
Published: August 2023

This article discusses the changing role of women in the family household to take full control and responsibility as a single parent due to the death of their husbands in the post-Covid-19 pandemic in Indonesia. Based on the Covid-19 pandemic data, the death of husbands is so high in East Java that raised new problems in the family household when a wife must switch her position to take role as the head of the family as a single parent. This article strives to answer the questions of what roles do the women play as the head of the household due to the death of their husbands? How are these roles perceived based on Maqashid Al-Syari’ah, a contemporary Islamic law? These questions aim to understand the transformation of roles between husband and wife in Javanese Muslim family households to portray the gender equality and the construction of the family resilience. The data of this study are collecter through ethnographic fieldwork with participatory observation and in-depth interviews to several married women in eastern parts of Java. This article suggests that mainstreaming the method of Islamic law, Maqashid Al-Syari’ah to build the resilience of single-parent families in East Java is realized by the awareness of single-parent women in meeting the family needs. This awareness is employed through various practices by women in East Java who cover all domestic and public activities for the benefit of the family.
Quantum chaos in interacting Bose-Bose mixtures
Authors: Duong Anh-Tai Tran , Mikkelsen Mathias , Busch Thomas , Fogarty Thomás
Published: August 2023

The appearance of chaotic quantum dynamics significantly depends on the symmetry properties of a system, and in cold atomic systems many of these can be experimentally controlled. In this work, we systematically study the emergence of quantum chaos in a minimal system describing one-dimensional harmonically trapped Bose-Bose mixtures by tuning the particle-particle interactions. Using an improved exact diagonalization scheme, we examine the transition from integrability to chaos when the inter-component interaction changes from weak to strong. Our study is based on the analysis of the level spacing distribution and the distribution of the matrix elements of observables in terms of the eigenstate thermalization hypothesis and their dynamics. We show that one can obtain strong signatures of chaos by increasing the inter-component interaction strength and breaking the symmetry of intra-component interactions.
Constant-time quantum algorithm for homology detection in closed curves
Authors: Nghiem Vu Nhat Anh , Gu Xianfeng David , Wei Tzu-Chieh
Published: August 2023

Given a loop or more generally 1-cycle rr of size L on a closed two-dimensional manifold or surface, represented by a triangulated mesh, a question in computational topology asks whether or not it is homologous to zero. We frame and tackle this problem in the quantum setting. Given an oracle that one can use to query the inclusion of edges on a closed curve, we design a quantum algorithm for such a homology detection with a constant running time, with respect to the size or the number of edges on the loop rr, requiring only a single usage of oracle. In contrast, classical algorithm requires \Omega(L)Ω(L) oracle usage, followed by a linear time processing and can be improved to logarithmic by using a parallel algorithm. Our quantum algorithm can be extended to check whether two closed loops belong to the same homology class. Furthermore, it can be applied to a specific problem in the homotopy detection, namely, checking whether two curves are not homotopically equivalent on a closed two-dimensional manifold.
LIGHT AT THE END OF TUNNEL- AN INNOVATIVE WAY OF BIOPSY MAPPING
Authors: S. Pagare Jaishri , N. Kale Gayatri
Published: August 2023

Oral cancer is a crucial global health issue with high morbidity and mortality rate. Oral cancer is preceded by clinically conspicuous oral potentially malignant disorders (OPMDs) and microscopically apparent altered epithelial changes known as oral epithelial dysplasia (OED). The current gold standard in the detection of precancer lesions and conditions is a biopsy. Even an experienced clinician finds it difficult to locate an appropriate biopsy site. To overcome this, a non-invasive, low-cost, portable device known as the Active Biopsy Guidance System (ABGS) has been developed. It is a software that combined multimodal optical imaging and microscopic imaging with real-time projection of cancer risk maps onto the field of view. ABGS, appropriately locate the biopsy site and improve the diagnostic precision. In this review, we attempt to demonstrate a biopsy guidance system, a versatile, quantitative precise tool in biopsy site selection.
PERIPHERAL OSSIFYING FIBROMA - A CASE REPORT
Authors: Pagare Jaishri , Chormale Ankita , Kasat Vikrant , R. Rohini
Published: August 2023

The gingiva in the oral cavity is constantly subjected to numerous stimuli, resulting in numerous localised growths. Reactive gingival growth is the most common lesion in the oral cavity and usually exhibits indolent behaviour. Many of these lesions are difficult to identify clinically and can be identified as specific entities only on the basis of typical and consistent histomorphology. A peripheral ossifying fibroma is one such reactive lesion. It has been described with various synonyms and is believed to arise from the periodontal ligament, which comprises about 9% of all gingival growths. Here we describe a case of a peripheral ossifying fibroma in a 15-year-old female patient in the anterior maxilla that was painless and pale pink. The purpose of this article is to present a case of POF and emphasize the importance of discussion of a reasonable differential diagnosis.