bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic and Phenotypic Variations Among Thai-53 and Mycobacterium leprae Clinical Isolates: Implications for Leprosy Pathogenesis and Research
Authors: Gomes Tiago Araujo , da Silva Tatiana Pereira , Machado Edson , Vasconcelos Sidra Ezidio Gonçalves , Mietto Bruno Siqueira , de Faria Bertoluci Daniela Ferreira , Rosa Patricia Sammarco , Pinheiro Roberta Olmo , Suffys Philip Noel , Lery Letícia Miranda Santos , Lara Flavio Alves
Published: November 2024

Throughout Mycobacterium leprae’s (M. leprae) evolutionary trajectory, nearly half of its genome was converted into pseudogenes. Despite this drastic reduction in genetic content, the genome sequence identity among M. leprae isolates worldwide is remarkably high compared to other pathogens. In this study, we investigated the genotype and morphotype of three M. leprae strains: the reference strain Thai-53 (genotype 1A), and two clinical isolates from Brazilian leprosy relapse patients, which were Br014-03 (genotypes 3I) and Br014-01(4N). We compared their genome sequences and their interaction with human Schwann cells from the ST88-14 lineage and with human primary macrophages. On the genetic level, we observed over a hundred missense mutations in the three strains, translated into significant phenotypic changes such as: prolonged doubling time, altered cytokine induction, reduced interaction rates, and decreased intracellular viability in Schwann cells. Our findings underscore the concept that despite their 99.992% identity, even small genomic disparities in M. leprae genomes can elicit substantial alterations in bacilli interaction with host cells and subsequent immune responses. Consequently, our data could lead to better comprehension of correlation between pathogen mutations and the diverse clinical manifestations observed in leprosy patients.
Correction: Curcio et al. The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods. Pharmaceuticals 2024, 17, 620
Authors: Curcio Antonio , Rocca Roberta , Alcaro Stefano , Artese Anna
Published: November 2024

In the original publication [...]
Eruption Disturbance in Children Receiving Bisphosphonates: Two Case Reports
Authors: Akitomo Tatsuya , Iwamoto Yuko , Kametani Mariko , Kaneki Ami , Nishimura Taku , Mitsuhata Chieko , Nomura Ryota
Published: November 2024

Background: Bisphosphonates used for the treatment of osteoporosis, hypercalcemia, or heterotopic calcifications can cause serious adverse dental events such as osteonecrosis of the maxillary and mandibular bones. However, the effects in childhood remain scarcely explored. Case Presentations: We encountered two children who had started bisphosphonate therapy before completion of the primary dentition. No systemic disease causing congenital delayed tooth eruption was diagnosed. Although the children’s height and weight increased with age, their tooth eruption was significantly delayed compared with the mean. The primary teeth gradually erupted in the follow-up period; however, some teeth did not completely erupt and needed to be extracted to allow for permanent tooth eruption. Conclusions: We report a case of children with early use of bisphosphonates and eruption disturbance, highlighting the need for further investigation into the relationship between these factors.
Synthesis and Anti-Inflammatory and Analgesic Potentials of Ethyl 2-(2,5-Dioxo-1-Phenylpyrrolidin-3-yl)-2-Methylpropanoate
Authors: Sadiq Abdul , Khan Muhammad Arif , Zafar Rehman , Ullah Farhat , Ahmad Sajjad , Ayaz Muhammad
Published: November 2024

Background/Objectives: Inflammation and analgesia are two prominent symptoms and often lead to chronic medical conditions. To control inflammation and analgesia, many marketed drugs are in practice but the majority of them have severe side effects. Methods: This study involved the synthesis of a pivalate-based Michael product and evaluated it for in vitro COX-1, COX-2, and 5-LOX inhibitory potentials using specific assays. Molecular docking studies were also assessed. Based on the in vitro results, the compound was also subjected to in vivo anti-inflammatory and antinociceptive studies. Results: The pivalate-based Michael product (MAK01) was synthesized by an organocatalytic asymmetric Michael addition of ethyl isobutyrate to N-phenylmaleimide with an isolated yield of 96%. The structure of the compound was confirmed through 1H and 13C NMR analyses. The observed IC50 values for COX-1, COX-2, and 5-LOX were 314, 130, and 105 μg/mL, respectively. The molecular docking studies on the synthesized compound showed binding interactions with the minimized pockets of the respective enzymes. In a carrageenan model, a percent reduction in edema when administered at 10 mg/kg (a reduction of 33.3 ± 0.77% at the second hour), 20 mg/kg (a reduction of 34.7 ± 0.74% at the second hour), and 30 mg/kg (a reduction of 40.58% ± 0.84% after the fifth hour) was observed. The compound showed a significant response at concentrations of 50, 100, and 150 mg/kg with latency times of 10.32 ± 0.82, 12.16 ± 0.51, and 12.93 ± 0.45 s, respectively. Conclusion: In this study, we synthesized a pivalate-based Michael product for the first time. Moreover, based on its rationality and potency, it was found to be an effective future medicine for the management of analgesia and inflammation.
Pharmaceutical Equivalence of Film-Coated and Chewable Tablets: A Comparative Dissolution Study Using Pulverized Chewable Tablets
Authors: Park Suck-Yong , Choi Sung-Up
Published: November 2024

Famotidine is a histamine H2 receptor antagonist used in the treatment of gastrointestinal disorders. It is available in multiple formulations, including film-coated tablets, chewable tablets, oral suspension, and injections. The purpose of this study was to develop and evaluate the film-coated tablet (FT) containing famotidine, magnesium hydroxide, and precipitated calcium carbonate, designed to be pharmaceutically equivalent to the marketed chewable tablet (CT). To achieve the pharmaceutical equivalence of two tablets, the dissolution profiles of FT should be similar to those of CT. However, since CT is intended to be chewed before swallowing, testing it in its intact form would not provide accurate results. Therefore, pulverized chewable tablets (PCT) were used as the reference product. The dissolution, performed by the paddle method at 50 rpm, was analyzed by the validated UV method. Similarity factor (f2) and difference factor (f1) were calculated to assess the equivalence of the dissolution profiles. The results demonstrated that the dissolution profiles of the FT and CT were similar. Additionally, the acid-neutralizing capacity test confirmed the equivalence of the two antacids. This study is one of the first to propose that dissolution tests for pharmaceutical equivalence should be conducted on pulverized CTs when developing generic equivalents to CTs.
Principles and Biomedical Applications of Self-Assembled Peptides: Potential Treatment of Type 2 Diabetes Mellitus
Authors: Mohammad Karim Alireza
Published: November 2024

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder worldwide. There have been tremendous efforts to find a safe and prolonged effective therapy for its treatment. Peptide hormones, from certain organisms in the human body, as the pharmaceutical agents, have shown outstanding profiles of efficacy and safety in plasma glucose regulation. Their therapeutic promises have undergone intensive investigations via examining their physicochemical and pharmacokinetic properties. Their major drawback is their short half-life in vivo. To address this challenge, researchers have recently started to apply the state-of-the-art molecular self-assembly on peptide hormones to form nanofibrillar structures, as a smart nanotherapeutic drug delivery technique, to tremendously enhance their prolonged bioactivity in vivo. This revolutionary therapeutic approach would significantly improve patient compliance. First, this review provides a comprehensive summary on the pathophysiology of T2DM, various efforts to treat this chronic disorder, and the limitations and drawbacks of these treatment approaches. Next, this review lays out detailed insights on various aspects of peptide self-assembly: adverse effects, potential applications in nanobiotechnology, thermodynamics and kinetics of the process, as well as the molecular structures of the self-assembled configurations. Furthermore, this review elucidates the recent efforts on applying reversible human-derived peptide self-assembly to generate highly organized smart nanostructured drug formulations known as nanofibrils to regulate and prolong the bioactivity of the human gut hormone peptides in vivo to treat T2DM. Finally, this review highlights the future research directions to advance the knowledge on the state-of-the-art peptide self-assembly process to apply the revolutionary smart nanotherapeutics for treatment of chronic disorders such as T2DM with highly improved patient compliance.
Effects of Baccharis dracunculifolia DC on an Innovative Animal Model of Cardiometabolic Syndrome
Authors: Silva Gustavo Ratti da , Kluck Arianne Jung , Albuquerque Edilson Rodrigues , Guarnier Lucas Pires , Braga Fernanda de Abreu , Silva Ester Pelegrini , Negrini Karina Sposito , Mendonça Juliana Aparecida , Gazim Zilda Cristiani , Gasparotto Junior Arquimedes , Ribeiro-Paes João Tadeu , Lívero Francislaine Aparecida dos Reis
Published: November 2024

Background/Objective: Cardiometabolic syndrome (CMS) is a complex clinical condition that encompasses metabolic dysregulation, cardiovascular disease, and diabetes risk factors. Worldwide, CMS is underdiagnosed, and its occurrence significantly increases cardiovascular morbimortality. Despite available pharmacological treatments, the approach is fragmented, and the associated clinical conditions are treated independently. This approach may be partially due to limited preclinical models to mimic the clinical conditions of CMS. Therefore, our study aims to present an innovative animal model of cardiometabolic syndrome and evaluate the effects of Baccharis dracunculifolia on the set of clinical alterations associated with the condition. Methods: Female Wistar rats were induced to develop diabetes, fed a cholesterol-enriched diet, and exposed to the smoke of 9 cigarettes/day for 6 weeks. During the last 2 weeks, the rats were treated with vehicle, B. dracunculifolia (30, 100, and 300 mg/kg), or a combination of simvastatin and insulin. At the end of the treatment, plasma lipid levels were measured, and the liver was analyzed histologically for hepatic lipid quantification and oxidative stress assessment. Results: Phytochemical analysis revealed seven phenolic acids and six flavonoids in the extract. B. dracunculifolia showed significant hepatoprotective effects, reducing AST and ALT levels and lowering both plasma and hepatic lipid levels. The extract also reversed hepatic steatosis and demonstrated antioxidant properties. Conclusions: These findings suggest that B. dracunculifolia may be a therapeutic option for the metabolic dysregulation present in CMS.
Amphiphilic Oligonucleotide Derivatives—Promising Tools for Therapeutics
Authors: Bauer Irina A. , Dmitrienko Elena V.
Published: November 2024

Recent advances in genetics and nucleic acid chemistry have created fundamentally new tools, both for practical applications in therapy and diagnostics and for fundamental genome editing tasks. Nucleic acid-based therapeutic agents offer a distinct advantage of selectively targeting the underlying cause of the disease. Nevertheless, despite the success achieved thus far, there remain unresolved issues regarding the improvement of the pharmacokinetic properties of therapeutic nucleic acids while preserving their biological activity. In order to address these challenges, there is a growing focus on the study of safe and effective delivery methods utilising modified nucleic acid analogues and their lipid bioconjugates. The present review article provides an overview of the current state of the art in the use of chemically modified nucleic acid derivatives for therapeutic applications, with a particular focus on oligonucleotides conjugated to lipid moieties. A systematic analysis has been conducted to investigate the ability of amphiphilic oligonucleotides to self-assemble into micelle-like structures, as well as the influence of non-covalent interactions of such derivatives with serum albumin on their biodistribution and therapeutic effects.
Multifunctional Near-Infrared Luminescence Performance of Nd3+ Doped SrSnO3 Phosphor
Authors: Hou Dejian , Li Jin-Yan , Huang Rui , Zhang Wenxing , Zhang Yi , Lin Zhenxu , Li Hongliang , Dong Jianhong , Lin Huihong , Zhou Lei
Published: November 2024

The phosphors with persistent luminescence in the NIR (near-infrared) region and the NIR-to-NIR Stokes luminescence properties have received considerable attention owing to their inclusive application prospects in the in vivo imaging field. In this paper, Nd3+ doped SrSnO3 phosphors with remarkable NIR emission performance were prepared using a high temperature solid state reaction method; the phase structure, morphology, and luminescence properties were discussed systematically. The SrSnO3 host exhibits broadband NIR emission (800–1300 nm) with absorptions in the near ultraviolet region. Nd3+ ions emerge excellent NIR-to-NIR Stokes luminescence under 808 nm laser excitation, with maximum emission at around ~1068 nm. The concentration-dependent luminescence properties, temperature dependent emission, and the luminescence decay curves of Nd3+ in the SrSnO3 host were also studied. The Nd3+ doped SrSnO3 phosphors exhibit exceptional thermal stability; the integrated emission intensity can retain approximately 66% at 423 K compared to room temperature. Most importantly, NIR persistent luminescence also can be observed for the SrSnO3:Nd3+ samples, which is in the first and second biological windows. A possible mechanism was proposed for the persistent NIR luminescence of Nd3+ based on the thermo-luminescence spectra. Consequently, the exciting results indicate that multifunctional NIR luminescence has been successfully realized in the SrSnO3:Nd3+ phosphors.
Plants Under Stress: Exploring Physiological and Molecular Responses to Nitrogen and Phosphorus Deficiency
Authors: Mishra Swarup , Levengood Hannah , Fan Jinping , Zhang Cankui
Published: November 2024

Nitrogen (N) and phosphorus (P) are essential mineral macronutrients critical for plant structure and function. Both contribute to processes ranging from cellular integrity to signal transduction. Since plants require these nutrients in high concentrations, replenishing them in soil often involves chemical fertilizers. However, the main source of P, rock phosphate, is non-renewable and in decline. N, second only to carbon, oxygen, and hydrogen in plant requirements, is vital for synthesizing proteins, nucleic acids, and plant pigments. Although N is available to plants through biological fixation or fertilizer application, the frequent application of N is not a sustainable solution due to environmental concerns like groundwater contamination and eutrophication. Plants have developed sophisticated mechanisms to adapt to nutrient deficiencies, such as changes in root architecture, local signaling, and long-distance signaling through the phloem. A dual deficiency of N and P is common in the field. In addition to individual N and P deficiency responses, this review also highlights some of the most recent discoveries in the responses of plants to the combined N and P deficiencies. Understanding the molecular and physiological responses in plants to mineral deficiency will help implement strategies to produce plants with high mineral use efficiency, leading to the reduced application of fertilizers, decreased mineral runoff, and improved environment.
Multi-Omics Analysis Uncovers the Mechanism for Enhanced Organic Acid Accumulation in Peach (Prunus persica L.) Fruit from High-Altitude Areas
Authors: Song Haiyan , Zhao Ke , Wang Xiaoan , Jiang Guoliang , Li Jing , He Chengyong , Wang Lingli , Sun Shuxia , Tu Meiyan , Wang Qiang , Gong Ronggao , Chen Dong
Published: November 2024

The early-ripening peach industry has undergone rapid development in the Panxi region of the Sichuan Basin in recent years. However, after the introduction of some new peach varieties to the high-altitude peach-producing areas in Panxi, the titratable acid content in peach fruit has significantly increased. This study compared the fruit quality indicators of early-ripening peach varieties cultivated in Xide County (a high-altitude peach-producing area) and Longquanyi District (a low-altitude peach-producing area) in Sichuan Province and analyzed the differences in organic acid metabolism by combining primary metabolomic and transcriptomic approaches. The results showed that the ‘Zhongtaohongyu’ fruit from the high-altitude peach-producing area had a much higher accumulation of malic acid and, accordingly, a significantly higher organic acid content than the other samples. The lower annual average temperature and stronger ultraviolet radiation in high-altitude peach-producing areas may lead to the increased expression of genes (PpNAD-ME1, PpNADP-ME3, and PpPEPC1) in the organic acid synthesis pathway and the decreased expression of genes (PpACO2, PpNAD-MDH2/3/4/5, and PpPEPCK2) in the organic acid degradation pathway in peach fruit, ultimately resulting in the accumulation of more organic acids. Among them, the downregulation of the key genes PpNAD-MDH3/4/5 involved in malic acid metabolism may be the main reason for the higher malic acid accumulation in peach fruit from high-altitude peach-producing areas. Overall, this study elucidates the mechanism by which environmental factors enhance the accumulation of organic acids in peach fruit from high-altitude peach-producing areas from a multi-omics perspective, as well as providing a theoretical basis for screening key genes involved in organic acid metabolism in peach fruit.
The Pulvinus Is the Weak Point for Stem Lodging Resistance in Ripe Barley
Authors: Gianinetti Alberto , Baronchelli Marina
Published: November 2024

Stem lodging is a serious problem for the ripe barley crop because it can reduce grain yield and quality. Although biometrical traits (stem diameter and wall thickness) and mechanical properties (stiffness and strength of the culm) have an obvious role in determining lodging resistance, they have only a partial capability to predict lodging resistance. We, therefore, investigated how factors like stem wetting and the point of application of the bending force affect the assessment of these traits. A three-point bending test using a height gauge can provide measures of bending strength (BS), material strength (σb), modulus of elasticity (E), and stiffness (EI). Since the first two parameters are of greatest interest, a quick manual method for measuring them is proposed. We used it specifically to compare the results of tests made by loading the bending force either on the node or the internode. It was shown that the pulvinus (which forms a complex with the node) is the weak point for mechanical resistance to bending in ripe barley stems, as a drop in BS between −31% and −41% (depending on whether the stems were dry or wet) was observed when the loading force was applied on the node/pulvinus complex with respect to the internode. We also found that, overall, BS plummeted −62% with respect to dry stems when the stems were wetted. This was due to an equivalent (−62%) plunge in σb. Similar drops in BS (−64%) and σb (−68%) following wetting were measured with the height gauge. Wetting, therefore, greatly lowers the mechanical resistance of stems. Moreover, the existence of a weak point—i.e., the pulvinus—in mature barley stems is an important feature that must be considered when evaluating the lodging-related characteristics of this crop. These findings improve our understanding of the mechanical properties of barley stems and, thus, our capability to identify genotypes with better lodging resistance.
Polymerization of Sodium 4-Styrenesulfonate Inside Filter Paper via Dielectric Barrier Discharge Plasma
Authors: Amiri Khoshkar Vandani Samira , Farhadian Lian , Pennycuick Alex , Ji Hai-Feng
Published: November 2024

This work explores the polymerization of sodium 4-styrenesulfonate (NaSS) inside filter paper using dielectric barrier discharge (DBD) plasma and its application in the environmental field. The plasma-based technique, performed under mild conditions, solves common problems associated with conventional polymerization inside porous materials. The polymerization process was monitored using Fourier-transform infrared (FTIR) spectroscopy, which confirmed the consumption of double bonds, particularly in NaSS samples containing the optimal concentration of crosslinker divinyl benzene (DVB) (0.25% wt). Our work demonstrates the effectiveness and promise of DBD plasma as a substitute polymerization approach, especially for those in porous materials.
Tribological and Hygroscopic Behavior of Polybutylene Terephthalate/Acrylonitrile Styrene Acrylate (PBT/ASA) Nanocomposites with Graphene Nanofiller
Authors: Lee Pyoung-Chan , Hong Seo-Hwa , Oh Ji Taek , Shin Donghyeok , Jung Jae-Uk , Ko Youn Ki , Ha Jin Uk , Kim Myeong-Gi , Cho Beom-Gon
Published: November 2024

Fogging in automotive headlamps is a significant issue that affects both aesthetics and functionality. This study investigates the use of graphene-based nanocomposites to mitigate fogging by enhancing the hygroscopic properties of polybutylene terephthalate/acrylonitrile styrene acrylate (PBT/ASA) composites commonly used in headlamps. The incorporation of functionalized graphene improved the tensile and flexural strength of the nanocomposites, though it led to a reduction in elongation and melt flow. Additionally, the solid lubrication properties and increased surface hardness of the graphene contributed to enhanced wear resistance. The presence of graphene in the nanocomposites also reduced moisture diffusion, lowering the rates of both hygroscopic and desorption when compared to commercial PBT/ASA composites. Furthermore, the nanocomposites exhibited a reduction in maximum moisture uptake. These improvements are expected to reduce the absolute humidity inside the headlamp, thereby effectively mitigating the fogging issue.
Simulation and Analysis of the Loading, Relaxation, and Recovery Behavior of Polyethylene and Its Pipes
Authors: Shi Furui , Jar P.-Y. Ben
Published: November 2024

Spring–dashpot models have long been used to simulate the mechanical behavior of polymers, but their usefulness is limited because multiple model parameter values can reproduce the experimental data. In view of this limitation, this study explores the possibility of improving uniqueness of parameter values so that the parameters can be used to establish the relationship between deformation and microstructural changes. An approach was developed based on stress during the loading, relaxation, and recovery of polyethylene. In total, 1000 sets of parameter values were determined for fitting the data from the relaxation stages with a discrepancy within 0.08 MPa. Despite a small discrepancy, the 1000 sets showed a wide range of variation, but one model parameter, σv,L0, followed two distinct paths rather than random distribution. The five selected sets of parameter values with discrepancies below 0.04 MPa were found to be highly consistent, except for the characteristic relaxation time. Therefore, this study concludes that the uniqueness of model parameter values can be improved to characterize the mechanical behavior of polyethylene. This approach then determined the quasi-static stress of four polyethylene pipes, which showed that these pipes had very close quasi-static stress. This indicates that the uniqueness of the parameter values can be improved for the spring–dashpot model, enabling further study using spring–dashpot models to characterize polyethylene’s microstructural changes during deformation.
Research on Crack Sealing Performance of Polymer Microsphere/Hydrogel Composite System
Authors: Liu Wenjin , Li Jun , Luo Taotao , Long Xueyuan
Published: November 2024

Owing to their excellent water-absorption and swelling properties, polymer microspheres have been extensively applied as deep profile control agents in oilfields. These microspheres effectively seal large pore-throat channels in reservoirs, optimizing the water-absorption profile. In this study, a composite system was developed, comprising polymer microspheres and polyacrylamide polymers, with the inclusion of a cross-linking agent. The system leverages the synergistic effects of polymer microspheres and other plugging techniques to efficiently seal fractured reservoirs. Results indicate that the composite system exhibits strong blocking and scour resistance due to enhanced network integrity, higher viscosity, and improved elastic strength. Additionally, the composite system demonstrates a notable self-repairing capability, maintaining a high sealing efficiency even after a waterflood breakthrough.
The Electrooxidation of Synthetic Bipyridyl Herbicide Wastewaters with Boron-Doped Diamond Electrodes: A Technical and Economic Study to Boost Their Application for Pollution Prevention in the Agricultural Sector
Authors: Teutli-Sequeira Elia Alejandra , Vasquez-Medrano Ruben , Prato-Garcia Dorian , Ibanez Jorge G.
Published: November 2024

Boron-doped diamond electrodes (BDDEs) offer a highly efficient pathway to mineralize recalcitrant compounds due to their reduced energy requirements, fewer chemical inputs, and mechanical stability. In this work, the electrochemical degradation of paraquat (PQ) and diquat (DQ) was studied using an undivided cell (Condiacell®-type) at circumneutral pH, and under galvanostatic control. The roles of applied current density, volumetric flow rate, and herbicide concentration were systematically studied through a central composite design (CCD) using a closed-flow reaction setup. Under the best operating conditions (i.e., for PQ: 1.6 mA/cm2, 80 mL/min, and 70 mL/min, and 70 mg/L; and for DQ: 1.5 mA/cm2, 80 mL/min, and 73 mg/L), a spectrophotometric analysis evidenced that the herbicides were satisfactorily removed (ca. 100%) while mineralization degrees were above 90%. Furthermore, the produced effluents yielded significant increases in seed germination and root length, which suggest a reduction in toxicity. Energy consumptions of 0.13 and 0.18 kWh/g of TOC are reported with the electrochemical cells for the PQ and DQ treatments, respectively. The PQ and DQ treatments by electrooxidation are estimated to emit nearly 2.7 and 38.9 kg CO2/m3 of water treated, with a cost around USD 250/m3. Carbon emissions could be greatly decreased for PQ (0.28 kg CO2/m3) and DQ (0.40 kg CO2/m3) if electricity were generated from renewable resources. Although this study suggests that the use of BDDE can be considered as a green alternative for agrochemical removal due to lower carbon emissions, the environmental profile of the process is determined by the degree of renewability of the electrical grid of each country or region.
Predicting Water Flowing Fracture Zone Height Using GRA and Optimized Neural Networks
Authors: Dong Haofu , Yang Genfa , Guo Keyin , Xu Junyu , Liu Deqiang , Han Jin , Shi Dongrui , Pan Jienan
Published: November 2024

As coal mining depths continue to rise, consideration of WFFZ elevations is becoming increasingly important to mine safety. The goal was to accurately predict the height of the WFFZ to effectively prevent and manage possible roof water catastrophes and ensure the ongoing safety of the mine. To achieve this goal, we combined the particle swarm optimisation (PSO) algorithm with a backpropagation neural network (BPNN) in order to enhance the accuracy of the forecast. The present study draws upon the capacity of the PSO algorithm to conduct global searches and the nonlinear mapping capability of the BPNN. Through grey relational analysis (GRA), the order of the correlation degree was as follows: mining thickness > mining depth > overburden structure > mining width > mining dip. GRA has identified the degree of correlation between five influencing factors and the height of the WFFZ, among these, mining thickness, mining depth, overburden structure and mining width all show strong correlations, and the mining dip of the coal seam shows a good correlation. The weight ranking obtained by the PSO-BPNN method was the same as that obtained by the GRA method. Based on two actual cases, the relative errors of the obtained prediction results after PSO implementation were 2.97% and 3.47%, while the relative errors of the BPNN before optimisation were 18.46% and 4.34%, respectively, indicating that the PSO-BPNN method provides satisfactory prediction results and demonstrating that the PSO-optimised BPNN is easy to use and yields reliable results. In this paper, the height of the WFFZ model under the influence of five factors is only established for the Northwest Mining Area. With the continuous progress of technology and research, the neural network can consider more factors affecting the height of hydraulic fracturing development zones in the future to improve the comprehensiveness and accuracy of prediction.
Production of Biodiesel from Industrial Sludge: Recent Progress, Challenges, Perspective
Authors: Aryanfar Yashar , Keçebaş Ali , Sadabad Arash Nourbakhsh , Alcaraz Jorge Luis García , Fernandez Julio Blanco , Wu Wei
Published: November 2024

This study investigated biodiesel production from industrial sludge, focusing on the feasibility and sustainability of converting waste materials into renewable energy sources. This study combines a comparative analysis of various sludge-based biodiesel production methods, highlighting both their environmental benefits and economic potential. Utilizing physical, chemical, and biological pre-treatments, this study optimizes biodiesel yield while assessing the impact of each method on the overall production efficiency. Key findings revealed that industrial sludge provides a viable feedstock, contributes to waste reduction, and reduces greenhouse gas emissions. The novel contributions of this study include a detailed economic assessment of biodiesel production from sludge and a comprehensive environmental impact evaluation that quantifies the potential sustainability benefits. Limitations related to scale-up processes are identified, and solutions to overcome these issues are discussed to improve industrial feasibility. Furthermore, the integration of sludge-based biodiesel production with other renewable energy systems has been explored as a future avenue to enhance energy efficiency and sustainability. This research contributes to a significant scientific niche by addressing scalability challenges and proposing future perspectives for sustainable biodiesel production from industrial waste.
Ignition Characteristics and Flame Behavior of Automotive Lubricating Oil on Hot Surfaces
Authors: Bai Lei , Cheng Fangming , Dong Yuting
Published: November 2024

Hot surfaces in industrial processes and automotive systems present a remarkable fire hazard. Lubricating oil is a widely used oil in these scenarios. Quantifying the ignition characteristics and flame behavior of lubricating oil on hot surfaces is critical for enhancing fire safety in energy-related applications. This paper utilizes a self-developed experimental platform for the hot surface ignition to systematically conduct combustion tests on lubricating oil with varying volumes at different surface temperatures. Through statistical analysis and image processing, the ignition temperature, flame height, flame propagation velocity, and flame temperature were examined to assess the fire risk of a hot surface ignition. The results demonstrate that the ignition and combustion process of lubricating oil on hot surfaces can be categorized into five stages. The ignition temperature decreases as the oil volume increases. The flame height and flame propagation velocity are positively correlated with the hot surface temperature. The maximum flame height increases with the increase in the oil volumes. When the flame height reaches the maximum value, the flame area is the largest, and the average flame temperature is 1540.30 °C, showing a greater fire risk. When the oil content is 0.2 mL, the flame propagation velocity is the fastest, reaching 3.81 m/s. Meanwhile, the flame is very close to the oil pipe, which may cause a secondary fire. Therefore, hot surface ignition of lubricating oil poses a direct threat to vehicle safety.
Is This the End of Anthropology as We Know It? Some Implication of FAIR Principles on Tales in Ethnological and Anthropological Qualitative Research
Authors: Orlić Olga
Published: November 2024

Open science, accessibility and knowledge sharing, especially of articles and monographs stemming from publicly funded research, seem to be moving in quite a positive direction toward scientific development and have received almost unanimous approval from the scientific community. However, when it comes to data sharing, the existing practice reveals a different picture, and not exclusively a discipline-dependent one. FAIR principles are developed and promoted as guiding tools for creating contextualized standards. The fact that data obtained by a qualitative methodology deserve special attention and treatment regarding the accessibility principle is recognized. Although FAIR principles provide ways to anonymize the data and interlocutors, individuals coming from smaller communities or even communities of practice can sometimes be easily recognized by members of the same community if data are openly accessed. Sometimes the interlocutors might agree with these terms, but sometimes they do not. According to the disciplinary code of ethics, a researcher is obliged to thoroughly describe the ways of the raw data management and usage, and in the case of mandatory raw data sharing (e.g., for receiving funding), it can inevitably impact the narratives collected. The prerogative to make all data open inevitably leads to autocensorship among interlocutors, i.e., resulting in a kind of FAIRy tale being collected. The article discusses the results obtained from the survey carried out among Croatian ethnologists and cultural anthropologists about the currently practiced data sharing, their attitudes about data sharing and their perceived behavior in hypothetical situations connected with data sharing. The results show mixed opinions about data sharing and a desire to follow the disciplinary code of ethics first, i.e., to follow the interlocutors’ wishes in the case of data management and usage.
On Tang Junyi’s Critique of Anselm’s Argument for the Existence of God
Authors: Dai Yumin
Published: November 2024

Anselm’s argument for the existence of God posits that the concept of God inherently implies its existence. Tang Junyi critiques this argument from two fundamental angles. Firstly, he argues that the contingency of human thought places an unwarranted burden of proof on the existence of God, introducing an inherent contradiction within the argument’s premise. Secondly, he contends that Anselm’s argument fails to deduce the existence of God from empirical things. Tang’s empirical approach to critiquing the argument bears a superficial resemblance to St. Thomas Aquinas’s cosmological argument for God’s existence, yet a profound difference exists between the two, precluding their equivalence. Delving deeper, Tang’s critique is rooted in the Confucian philosophy. Nevertheless, Tang’s critique, while insightful, does not fully dismantle Anselm’s argument, underscoring the intrinsic differences and tensions between Chinese and Western perspectives on religion and philosophy.
Enhancing Long-Term Robustness of Inter-Space Laser Links in Space Gravitational Wave Detection: An Adaptive Weight Optimization Method for Multi-Attitude Sensors Data Fusion
Authors: Cui Zhao , Wang Xue , Yang Jinke , Shi Haoqi , Liang Bo , Qian Xingguang , Ye Zongjin , Jia Jianjun , Wang Yikun , Wang Jianyu
Published: November 2024

The stable and high-precision acquisition of attitude data is crucial for sustaining the long-term robustness of laser links to detect gravitational waves in space. We introduce an effective method that utilizes an adaptive weight optimization approach for the fusion of attitude data obtained from charge-coupled device (CCD) spot-positioning-based attitude measurements, differential power sensing (DPS), and differential wavefront sensing (DWS). This approach aims to obtain more robust and lower-noise-level attitude data. A system is designed based on the Michelson interferometer for link simulations; validation experiments are also conducted. The experimental results demonstrate that the fused data exhibit higher robustness. Even in the case of a single sensor failure, valid attitude data can still be obtained. Additionally, the fused data have lower noise levels, with root mean square errors of 9.5%, 37.4%, and 93.4% for the single CCD, DPS, and DWS noise errors, respectively.
Impact of Arable Land Abandonment on Crop Production Losses in Ukraine During the Armed Conflict
Authors: Dai Kaixuan , Cheng Changxiu , Kan Siyi , Li Yaoming , Liu Kunran , Wu Xudong
Published: November 2024

The outbreak of Russia-Ukraine conflict casted an impact on the global food market, which was believed to be attributed to that Ukraine has suffered significant production losses due to cropland abandonment. Nevertheless, recent outbreaks of farmer protests against Ukraine’s grain exports demonstrated that the production losses might not be as severe as previous estimates. By utilizing the adaptive threshold segmentation method to extract abandoned cropland from the Sentinel-2 high-resolution imagery and calibrating the spatial production allocation model’s gridded crop production data from Ukraine’s statistical data, this study explicitly evaluated Ukraine’s crop-specific production losses and the spatial heterogeneity. The results demonstrated that the estimated area of abandoned cropland in Ukraine ranges from 2.34 to 2.40 million hectares, constituting 7.14% to 7.30% of the total cropland. In Ukrainian-controlled zones, this area spans 1.44 to 1.48 million hectares, whereas in Russian-occupied areas, it varies from 0.90 to 0.92 million hectares. Additionally, the total production losses for wheat, maize, barley, and sunflower amount to 1.92, 1.67, 0.70, and 0.99 million tons, respectively, with corresponding loss ratios of 9.10%, 7.48%, 9.54%, and 8.67%. Furthermore, production losses of wheat, barley, and sunflower emerged in both the eastern and southern states adjacent to the conflict frontlines, while maize losses were concentrated in the western states. The findings imply that Ukraine ought to streamline the food transportation channels and maintain stable agricultural activities in regions with high crop production.
High-Resolution Spaceborne SAR Geolocation Accuracy Analysis and Error Correction
Authors: Li Facheng , Zeng Qiming
Published: November 2024

High-accuracy geolocation is crucial for high-resolution spaceborne SAR images. Most advanced SAR satellites have a theoretical geolocation accuracy better than 1 m, but this may be unrealizable with less accurate external data, such as atmospheric parameters and ground elevations. To investigate the actual SAR geolocation accuracy in common applications, we analyze the properties of different geolocation errors, propose a geolocation procedure, and conduct experiments on TerraSAR-X images and a pair of Tianhui-2 images. The results show that based on GNSS elevations, the geolocation accuracy is better than 1 m for TerraSAR-X and 2 m/4 m for the Tianhui-2 reference/secondary satellites. Based on the WorldDEM and the SRTM, additional geolocation errors of 2 m and 4 m are introduced, respectively. By comparing the effectiveness of different tropospheric correction methods, we find that the GACOS mapping method has advantages in terms of resolution and computational efficiency. We conclude that tropospheric errors and ground elevation errors are the primary factors influencing geolocation accuracy, and the key to improving accuracy is to use higher-accuracy DEMs. Additionally, we propose and validate a geolocation model for the Tianhui-2 secondary satellite.
Analysis of Spatio-Temporal Relationship Between Ecosystem Services and Human Footprints Under Different Human Activity Gradients: A Case Study of Xiangjiang River Basin
Authors: Chen Songjia , Yan Junhua , Wang Yingping , Chang Zhongbin , Yu Guangcan , Li Jie , Jiang Jun , Wang Linhua , Zhang Shuo , Chen Yang , Xu Pingping , Wang Cong , Yan Xinyu , Liu Chunyi , Qiu Sihui , Fanrong Siyuan , Yu Mengxiao
Published: November 2024

Clarifying the relationship between human activities and the provision of ecosystem services has received significant interest in recent years because of a growing need for sustainable socio-ecological system development. Using multi-source remote sensing data, we assessed the spatial and temporal distribution of the human footprint index and five ecosystem services under four human activity gradients from 2010 to 2020 in the Xiangjiang River Basin. The five ecosystem services include water supply, soil conservation, food production, habitat quality, and carbon sequestration. The relationship between human footprint and ecosystem services was analyzed from quantitative and spatial perspectives. The results showed that over the past 10 years, water supply and habitat quality decreased by 4.59% and 16.49%, respectively. The other three services increased, and the upstream area of the basin had a higher level of ecosystem services provision. The human footprint index increased by 28.83% over the 10 years and was characterized by point and patchy clustering in the middle and lower reaches. In terms of quantitative characteristics, the relationship between human footprint and ecosystem services was primarily negative. The ecosystem services were sensitive to the human footprint index within the 0−0.4 range. In terms of spatial characteristics, the relationship was dominated by trade-offs. The risky “high–low” trade-offs were mainly distributed in the middle and lower reaches. As the gradients of human activity increased, the maximum fluctuation in ESs was 43%, and the maximum fluctuation in human footprint was 28%, making their relationship more complex. Our results identified response thresholds of ecosystem services to human activities, providing a guide for ecological management and sustainable development of basins.
Performance Evaluation of Satellite Precipitation Products During Extreme Events—The Case of the Medicane Daniel in Thessaly, Greece
Authors: Katsanos Dimitrios , Retalis Adrianos , Kalogiros John , Psiloglou Basil E. , Roukounakis Nikolaos , Anagnostou Marios
Published: November 2024

Mediterranean tropical-like cyclones, or Medicanes, present unique challenges for precipitation estimations due to their rapid development and localized impacts. This study evaluates the performance of satellite precipitation products in capturing the precipitation associated with Medicane Daniel that struck Greece in early September 2023. Utilizing a combination of ground-based observations, reanalysis, and satellite-derived precipitation data, we assess the accuracy and spatial distribution of the satellite precipitation products GPM IMERG, GSMaP, and CMOPRH during the cyclone event, which formed in the Eastern Mediterranean from 4 to 7 September 2023, hitting with unprecedented, enormous amounts of rainfall, especially in the region of Thessaly in central Greece. The results indicate that, while satellite precipitation products demonstrate overall skill in capturing the broad-scale precipitation patterns associated with Medicane Daniel, discrepancies exist in estimating localized intense rainfall rates, particularly in convective cells within the cyclone’s core. Indeed, most of the satellite precipitation products studied in this work showed a misplacement of the highest amounts of associated rainfall, a significant underestimation of the event, and large unbiased root mean square error in the areas of heavy precipitation. The total precipitation field from IMERG Late Run and CMORPH showed the smallest bias (but significant) and good temporal correlation against rain gauges and ERA5-Land reanalysis data as a reference, while IMERG Final Run and GSMaP showed the largest underestimation and overestimation, respectively. Further investigation is needed to improve the representation of extreme precipitation events associated with tropical-like cyclones in satellite precipitation products.
Comprehensive Analysis of BDS/GNSS Differential Code Bias and Compatibility Performance
Authors: Wang Yafeng , Yue Dongjie , Wang Hu , Ma Hongyang , Liu Zhiqiang , Yue Caiya
Published: November 2024

High-precision DCBs are essential for effective multi-frequency and multi-constellation GNSS integration, especially in processing compatible signal observations. This study utilizes data from MGEX, iGMAS, and CORS stations to estimate and analyze long time series of BDS/GNSS DCBs, focusing on stability and influencing factors. Results indicate that DCBs for the same signal, but different channels exhibit similar ranges and trends. Among BDS DCBs, those from satellites with rubidium atomic clocks are more stable than those with hydrogen atomic clocks. An upgrade and maintenance of BDS in late 2022, reported by NABU, likely contributed to DCB jumps. BDS-compatible signal DCBs show weaker stability compared to GPS and Galileo. Variations in GNSS signal processing and receiver algorithms also impact DCB stability. Converting DCBs to OSBs and performing RMS statistics revealed that smaller differences between signals increase the susceptibility of observation equations to observation quality.
Correction: Ebrahimi, A.; Czarnuch, S. Automatic Super-Surface Removal in Complex 3D Indoor Environments Using Iterative Region-Based RANSAC. Sensors 2021, 21, 3724
Authors: Ebrahimi Ali , Czarnuch Stephen
Published: November 2024

Affiliation Correction [...]
Design and Performance of an InAs Quantum Dot Scintillator with Integrated Photodetector
Authors: Mahajan Tushar , Minns Allan , Tokranov Vadim , Yakimov Michael , Hedges Michael , Murat Pavel , Oktyabrsky Serge
Published: November 2024

A new scintillation material composed of InAs quantum dots (QDs) hosted within a GaAs matrix was developed, and its performance with different types of radiation is evaluated. A methodology for designing an integrated photodetector (PD) with a low defect density and that is optically matched to the QD’s emission spectrum is introduced, utilizing an engineered epitaxial InAlGaAs metamorphic buffer layer. The photoluminescence (PL) collection efficiency of the integrated PD is examined using two-dimensional scanning laser excitation. The detector response to 5.5 MeV α-particles and 122 keV photons is presented. Yields of 13 electrons/keV for α-particles and 30–60 electrons/keV for photons were observed. The energy resolution of 12% observed with α-particles was mainly limited by noise- and geometry-related optical losses. The radiation hardness of an InAs QDs hosted within GaAs and a wider band gap AlGaAs ternary alloy was studied under a 1 MeV proton implantation up to a 1014 cm−2 dose. The integrated PL responses were compared to evaluate PL quenching due to non-radiative defects. The QDs embedded in the AlGaAs demonstrated improved radiation hardness compared to QDs in the GaAs matrix and in the InGaAs quantum wells.