bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetics and Genomic Regions Affecting Response to Newcastle Disease Virus Infection under Heat Stress in Layer Chickens
Authors: Saelao Perot , Wang Ying , Chanthavixay Ganrea , Gallardo Rodrigo A. , Wolc Anna , Dekkers Jack C. M. , Lamont Susan J. , Kelly Terra , Zhou Huaijun
Published: January 2019

Newcastle disease virus (NDV) is a highly contagious avian pathogen that poses a tremendous threat to poultry producers in endemic zones due to its epidemic potential. To investigate host genetic resistance to NDV while under the effects of heat stress, a genome-wide association study (GWAS) was performed on Hy-Line Brown layer chickens that were challenged with NDV while under high ambient temperature to identify regions associated with host viral titer, circulating anti-NDV antibody titer, and body weight change. A single nucleotide polymorphism (SNP) on chromosome 1 was associated with viral titer at two days post-infection (dpi), while 30 SNPs spanning a quantitative trait loci (QTL) on chromosome 24 were associated with viral titer at 6 dpi. Immune related genes, such as CAMK1d and CCDC3 on chromosome 1, associated with viral titer at 2 dpi, and TIRAP, ETS1, and KIRREL3, associated with viral titer at 6 dpi, were located in two QTL regions for viral titer that were identified in this study. This study identified genomic regions and candidate genes that are associated with response to NDV during heat stress in Hy-Line Brown layer chickens. Regions identified for viral titer on chromosome 1 and 24, at 2 and 6 dpi, respectively, included several genes that have key roles in regulating the immune response.
A New Model Describing Copper Dose–Toxicity to Tomato and Bok Choy Growth in a Wide Range of Soils
Authors: Jiang Bao , Ma Yibing , Zhu Guangyun , Li Jun
Published: January 2019

Phytotoxicity thresholds for heavy metals are derived from dose–response curves, which show the relationships between exposure dose and toxicity response. However, the results of tests or observations are commonly based on total heavy metal concentration, not the exposure dose that causes phytotoxicity; additionally, the phytotoxicity response differs with plant species. In the present study, the ethylenediaminetetraacetic acid (EDTA)-extractable copper (Cu) concentration was determined in order to evaluate Cu extractability. As two important horticultural food crops in Asia, tomato (Lycopersicon esculentum ‘Meifen No. 1’) and bok choy (Brassica rapa var. chinensis ‘Susheng 28’) were used to investigate Cu phytotoxicity in a wide range of Chinese soils with and without leaching treatment, after which relationships between Cu phytotoxicity thresholds based on EDTA-extractions and soil properties were established. The phytotoxicity thresholds showed that biomass of bok choy was more sensitive to Cu than tomato. Multiple linear regression analyses showed that soil factors, including organic carbon (OC), citrate dithionate extractable manganese (CD-Mn), cation exchange capacity (CEC), and CaCO3 explained over 85% of the variance in Cu phytotoxicity thresholds. The EDTA-extractable Cu dose–response relationships were further improved by incorporating soil properties. The new phytotoxicity predictive models indicated soil properties (soil pH, OC, CEC, and oxalate-extractable Mn) and EDTA-extractable Cu concentration explained more than 90% of the variance in the phytotoxicity response of tomato and bok choy biomass. The new phytotoxicity predictive models could be used to develop a reasonable remediation strategy for contaminated soils.
Effect of a Multicomponent Intervention on Lifestyle Factors among Brazilian Adolescents from Low Human Development Index Areas: A Cluster-Randomized Controlled Trial
Authors: Barbosa Filho Valter Cordeiro , Bandeira Alexsandra da Silva , Minatto Giseli , Linard Jair Gomes , Silva Jaqueline Aragoni da , Costa Rafael Martins da , Manta Sofia Wolker , Sá Soraya Anita Mendes de , Matias Thiago Sousa , Silva Kelly Samara da
Published: January 2019

Promoting healthy lifestyle factors (e.g., physical activity, healthy eating, less screen time) among young people is a relevant and challenging step toward reducing non-communicable diseases. This study aimed to evaluate the effect of a multicomponent intervention on lifestyle factors among adolescents from schools in low Human Development Index (HDI < 0.500) areas. The Fortaleça sua Saúde program was conducted with 548 adolescents aged 11–18 years old in the intervention group and 537 in the control group. The four-month intervention included strategies focused on training teachers, new opportunities for physical activity in the school environment, and health education strategies for the school community (including parents). Moderate- to-vigorous physical activity level (≥420 min/week), TV watching and computer use/gaming (<2 h/day), daily consumption of fruit juice, fruit, vegetables, soft drinks, savory foods and sweets, and current alcohol and tobacco use were measured before and after intervention. McNemar’s test and logistic regression (odds ratio [OR] and a 95% confidence interval [95% CI]) were used, considering p < 0.05. In the intervention schools, a significant increase occurred in the number of adolescents who met physical activity guidelines (5.3%; 95% CI = 0.8; 9.8) and who reported using computer for <2 h a day (8.6%; 95% CI = 3.8; 13.4) after intervention. No changes were observed in the control schools. At the end of the intervention, adolescents from intervention schools were more likely to practice physical activity at recommended levels (OR = 1.44; 95% CI = 1.00; 2.08) than adolescents from control schools. No significant change was observed for the other lifestyle factors. In conclusion, this multicomponent intervention was effective in promoting physical activity among adolescents from vulnerable areas. However, other lifestyle factors showed no significant change after intervention. This study is registered at Clinicaltrials.gov NCT02439827.
Different Trends in Microbial Contamination between Two Types of Microfiltered Water Dispensers: From Risk Analysis to Consumer Health Preservation
Authors: Girolamini Luna , Lizzadro Jessica , Mazzotta Marta , Iervolino Matteo , Dormi Ada , Cristino Sandra
Published: January 2019

The use of microfiltered water dispensers (MWDs) for treatment of municipal water is increasing rapidly, however, the water quality produced by MWDs has not been widely investigated. In this work a large-scale microbiological investigation was conducted on 46 MWDs. In accordance with Italian regulations for drinking water, we investigated the heterotrophic plate counts at 36 and 22 °C for indicator bacteria and pathogenic bacteria, such as Enterococci, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. Two different MWDs were compared: Type A with Ag+ coated carbon filter and two ultraviolet (UV) lamps, and Type B with a carbon filter and one UV lamp. For each type, the contamination of the input and output points was analyzed. Our findings showed that MWDs are a source of bacteria growth, with output being more contaminated than the input point. Type B was widely contaminated for all parameters tested in both sampling points, suggesting that water treatment by Type A is more effective in controlling bacterial contamination. MWDs are critical devices for water treatment in term of technologies, intended use, and sanitization procedures. The adoption of an appropriate drinking water safety plan associated with clear maintenance procedures and periodic environmental monitoring can ensure the safe and healthy operation of these devices.
The Effect of Prenatal Stress, Proxied by Marital and Paternity Status, on the Risk of Preterm Birth
Authors: Merklinger-Gruchala Anna , Kapiszewska Maria
Published: January 2019

Uncertainty and insecurity in the relationship between the mother and father of a child are responsible for heightened maternal stress, which can lead to preterm birth (PTB). Different intensities of prenatal stress (proxied by four levels of marital status linked with the presence or absence of paternal data on birth records) were defined as the Marital-Father Data index. We assessed the impact of those varying intensities of prenatal stress on PTB with respect to parity among a group of Polish mothers residing in Krakow (N = 87,916). We found a pattern across the adjusted risk ratios (RR) of preterm birth that ordered these estimates in an increasing trend towards higher risk, beginning with the group of married mothers with father data present (baseline), through the groups of legitimizing marriages—married after conception with father data present (RR = 1.1; 95% Confidence Intervals (CI) 1.0–1.2) and unmarried mothers with father data present (RR = 1.3; 95% CI 1.2–1.5) to the group of unmarried mothers with father data absent (RR = 1.9; 95% CI 1.7–2.2). The adjusted p for the linear trend between Marital-Father Data index and PTB was less than 0.001. The adjusted effect of perceived prenatal stress differed with respect to parity (confirmed by statistically significant interactions between Marital-Father Data index levels and parity), with a higher magnitude of this effect noted among multiparous versus primiparous women. Low paternal involvement and support during pregnancy may negatively affect PTB risk and this effect may differ in relation to parity status. More attention should be paid to maternal pregnancy stress, especially of multiparous mothers, to decrease the risk of unfavorable birth outcomes.
Social Capital Associated with Quality of Life among People Living with HIV/AIDS in Nanchang, China
Authors: Xie Fei , Zheng Huilie , Huang Ling , Yuan Zhaokang , Lu Yuanan
Published: January 2019

Background: This study aims to explore the relationship between quality of life (QOL) and social capital factors among “people living with HIV/AIDS” (PLWHA), in order to improve their quality of life and help them to release AIDS discrimination. Methods: A cross-sectional survey with 225 PLWHA was done in Nanchang, China, between January and June of 2015. Questionnaires consisted of a socio-demographic questionnaire, Personal Social Capital Scale and Medical Outcomes Study HIV Health Survey. To identify social capital factors influencing QOL among PLWHA, t-test and multiple linear regression were used as statistical tools. The analysis of data was conducted using SPSS 22.0 with a significant value of p < 0.05. Results: The scores of total social capital, bonding social capital and bridging social capital were 23.68 ± 5.55, 14.11 ± 3.40 and 9.46 ± 3.43 respectively. The scores of Physical Health Summary (PHS) and Mental Health Summary (MHS) were 51.88 ± 7.04 and 49.29 ± 6.60. Multiple linear regression analysis showed that age (B = −0.137, p = 0.020), income (B = 0.2170, p ≤ 0.001), employment (B = 0.112, p = 0.043) and bonding social capital (B = 0.178, p = 0.001) had significant effects on PHS. Bonding social capital was the most important influencing factor for MHS (B = 0.506, p < 0.001). There was no significant relationship between bridging social capital and QOL (p > 0.05). Conclusions: The PLWHA community has low social capital and a poor QOL in Nanchang. Bonding social capital had a positive impact on the QOL of PLWHA. There is an urgent need to build a better social support system based on bonding social capital for PLWHA. It is worth further exploring to identify how to make full use of bridging social capital for improving QOL among PLWHA.
An Analysis of the Evolution, Completeness and Spatial Patterns of OpenStreetMap Building Data in China
Authors: Tian YuanJian , Zhou Qi , Fu Xiaolin
Published: January 2019

OpenStreetMap (OSM) is a free map that can be created, edited, and updated by volunteers globally. The quality of OSM datasets is therefore of great concern. Extensive studies have focused on assessing the completeness (a quality measure) of OSM datasets in various countries, but very few have been paid attention to investigating the OSM building dataset in China. This study aims to present an analysis of the evolution, completeness and spatial patterns of OSM building data in China across the years 2012 to 2017. This is done using two quality indicators, OSM building count and OSM building density, although a corresponding reference dataset for the whole country is not freely available. Development of OSM building counts from 2012 to 2017 is analyzed in terms of provincial- and prefecture-level divisions. Factors that may affect the development of OSM building data in China are also analyzed. A 1 × 1 km2 regular grid is overlapped onto urban areas of each prefecture-level division, and the OSM building density of each grid cell is calculated. Spatial distributions of high-density grid cells for prefecture-level divisions are analyzed. Results show that: (1) the OSM building count increases by almost 20 times from 2012 to 2017, and in most cases, economic (gross domestic product) and OSM road length are two factors that may influence the development of OSM building data in China; (2) most grid cells in urban areas do not have any building data, but two typical patterns (dispersion and aggregation) of high-density grid cells are found among prefecture-level divisions.
Rootstock-Mediated Effects on Cabernet Sauvignon Performance: Vine Growth, Berry Ripening, Flavonoids, and Aromatic Profiles
Authors: Wang Yu , Chen Wei-Kai , Gao Xiao-Tong , He Lei , Yang Xiao-Hui , He Fei , Duan Chang-Qing , Wang Jun
Published: January 2019

Rootstocks are widely used in viticulture due to their resistance to biotic and abiotic stress. Additionally, rootstocks can affect vine growth and berry quality. This study evaluated the effects of eight rootstocks (101-14, 110R, 5A, 5BB, Ganzin 1, Harmony, Riparia Gloire, and SO4) on the vine growth, berry ripening, and flavonoids and aromatic profiles of Cabernet Sauvignon in two consecutive seasons (2015–2016). With few exceptions, minor differences were observed among grafted and own-rooted vines. Own-rooted vines produced the least pruning weight but the highest yield. 101-14, 5BB, and SO4 slightly reduced total soluble solids, but increased acidity, showing tendencies for retarding maturation. Ganzin 1 inhibited the accumulation of flavan-3-ols in berry skins. Furthermore, concentrations and proportions of epicatechin-3-O-galate were decreased by rootstocks, except for 110R. 5A, Harmony, and Riparia Gloire enhanced flavonol concentrations. SO4 slightly decreased most of the individual anthocyanin concentrations. With respect to volatile compounds, 110R, Riparia Gloire, and SO4 induced reductions in concentrations of total esters, whilst 101-14, Ganzin 1, 110R, and 5BB led to increases in the concentrations of C13-norisoprenoids. Therefore, with respect to the negative effects of SO4 on berry ripening and the accumulation of anthocyanin and volatile esters, SO4 is not recommended in practice.
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis
Authors: Zhang Xincai , Gao Xiangting , Hu Jun , Xie Yuxin , Zuo Yuanyi , Xu Hongfei , Zhu Shaohua
Published: January 2019

Adenosine deaminases acting on RNA (ADAR) are enzymes that regulate RNA metabolism through post-transcriptional mechanisms. ADAR1 is involved in a variety of pathological conditions including inflammation, cancer, and the host defense against viral infections. However, the role of ADAR1p150 in vascular disease remains unclear. In this study, we examined the expression of ADAR1p150 and its role in viral myocarditis (VMC) in a mouse model. VMC mouse cardiomyocytes showed significantly higher expression of ADAR1p150 compared to the control samples. Coimmunoprecipitation verified that ADAR1p150 forms a complex with Dicer in VMC. miRNA-222, which is involved in many cardiac diseases, is highly expressed in cardiomyocytes in VMC. In addition, the expression of miRNA-222 was promoted by ADAR1p150/Dicer. Among the target genes of miRNA-222, the expression of phosphatase-and-tensin (PTEN) protein was significantly reduced in VMC. By using a bioinformatics tool, we found a potential binding site of miRNA-222 on the PTEN gene’s 3′-UTR, suggesting that miRNA-222 might play a regulatory role. In cultured cells, miR-222 suppressed PTEN expression. Our findings suggest that ADAR1p150 plays a key role in complexing with Dicer and promoting the expression of miRNA-222, the latter of which suppresses the expression of the target gene PTEN during VMC. Our work reveals a previously unknown role of ADAR1p150 in gene expression in VMC.
Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development
Authors: Lin Tao , Lee Jae Eun , Kang Jung Won , Shin Hyeon Yeong , Lee Ju Bin , Jin Dong Il
Published: January 2019

Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic reticulum (ER) to maintain oocyte and embryo development. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of ER stress and unfolded protein response (UPR) signaling pathways. ER stress and UPR signaling have been identified in mammalian oocytes and embryos produced in vitro, suggesting that modulation of ER stress and UPR signaling play very important roles in oocyte maturation and the development of preimplantation embryos. In this review, we briefly describe the current state of knowledge regarding ER stress, UPR signaling pathways, and their roles and mechanisms in mammalian (excluding human) oocyte maturation and preimplantation embryo development.
Arabidopsis CNGC Family Members Contribute to Heavy Metal Ion Uptake in Plants
Authors: Moon Ju Yeon , Belloeil Célestine , Ianna Madeline Louise , Shin Ryoung
Published: January 2019

Heavy metal ions, including toxic concentrations of essential ions, negatively affect diverse metabolic and cellular processes. Heavy metal ions are known to enter cells in a non-selective manner; however, few studies have examined the regulation of heavy metal ion transport. Plant cyclic nucleotide-gated channels (CNGCs), a type of Ca2+-permeable-channel, have been suggested to be involved in the uptake of both essential and toxic cations. To determine the candidates responsible for heavy metal ion transport, a series of Arabidopsis CNGC mutants were examined for their response to Pb2+ and Cd2+ ions. The primary focus was on root growth and the analysis of the concentration of heavy metals in plants. Results, based on the analysis of primary root length, indicated that AtCNGC1, AtCNGC10, AtCNGC13 and AtCNGC19 play roles in Pb2+ toxicity, while AtCNGC11, AtCNGC13, AtCNGC16 and AtCNGC20 function in Cd2+ toxicity in Arabidopsis. Ion content analysis verified that the mutations of AtCNGC1 and AtCNGC13 resulted in reduced Pb2+ accumulation, while the mutations of AtCNGC11, AtCNGC15 and AtCNGC19 resulted in less Pb2+ and Cd2+ accumulation in plants. These findings provide functional evidence which support the roles of these AtCNGCs in the uptake and transport of Pb2+ or Cd2+ ion in plants.
Understanding Changes in Tomato Cell Walls in Roots and Fruits: The Contribution of Arbuscular Mycorrhizal Colonization
Authors: Chialva Matteo , Fangel Jonatan U. , Novero Mara , Zouari Inès , Salvioli di Fossalunga Alessandra , Willats William G. T. , Bonfante Paola , Balestrini Raffaella
Published: January 2019

Modifications in cell wall composition, which can be accompanied by changes in its structure, were already reported during plant interactions with other organisms, such as the mycorrhizal fungi. Arbuscular mycorrhizal (AM) fungi are among the most widespread soil organisms that colonize the roots of land plants, where they facilitate mineral nutrient uptake from the soil in exchange for plant-assimilated carbon. In AM symbiosis, the host plasma membrane invaginates and proliferates around all the developing intracellular fungal structures, and cell wall material is laid down between this membrane and the fungal cell surface. In addition, to improve host nutrition and tolerance/resistance to environmental stresses, AM symbiosis was shown to modulate fruit features. In this study, Comprehensive Microarray Polymer Profiling (CoMMP) technique was used to verify the impact of the AM symbiosis on the tomato cell wall composition both at local (root) and systemic level (fruit). Multivariate data analyses were performed on the obtained datasets looking for the effects of fertilization, inoculation with AM fungi, and the fruit ripening stage. Results allowed for the discernment of cell wall component modifications that were correlated with mycorrhizal colonization, showing a different tomato response to AM colonization and high fertilization, both at the root and the systemic level.
Softening the Donor-Set: From [Cu(P^P)(N^N)][PF6] to [Cu(P^P)(N^S)][PF6]
Authors: Nohara Isaak , Prescimone Alessandro , Housecroft Catherine E. , Constable Edwin C.
Published: January 2019

We report the synthesis and characterization of [Cu(P^P)(N^S)][PF6] complexes with P^P = bis(2-(diphenylphosphino)phenyl) ether (POP) or 4,5-bis(diphenylphosphino)-9,9- dimethylxanthene (xantphos) and N^S = 2-(iso-propylthio)pyridine (iPrSpy) or 2-(tert-butylthio)pyridine (tBuSpy). The single crystal structures of [Cu(POP)(iPrSPy)][PF6] and [Cu(POP)(tBuSPy)][PF6] have been determined and confirm a distorted tetrahedral copper(I) centre and chelating P^P and N^S ligands in each complex. Variable temperature (VT) 1H and 31P{1H} NMR spectroscopy reveals dynamic behavior with motion of the POP backbone in [Cu(POP)(iPrSPy)][PF6] and [Cu(POP)(tBuSPy)][PF6] frozen out at 238 K. VT NMR spectroscopic data including EXSY peaks in the ROESY spectrum of [Cu(xantphos)(tBuSPy)][PF6] at 198 K reveal that two conformers exist in an approximate ratio of 5:1. Replacing bpy by the N^S ligands shifts the Cu+/Cu2+ oxidation to a higher potential. The copper(I) compounds are weak emitters in the solid state with PLQY values of <2%. These values are similar to those for [Cu(POP)(bpy)][PF6] and [Cu(xantphos)(bpy)][PF6] in the solid state.
Heat Transfer and Its Innovative Applications
Authors: Chen Ping-Hei , Cho Hyung Hee
Published: January 2019

Innovative and high-end techniques have been recently developed in academic institutes and are gradually being employed in our daily lives for improving living quality, namely, artificial intelligence (AI) technology, autonomous cars, hyper-loop for high-speed transportation, miniaturization of electronic devices, heat dissipation from cooling films to outer space, and so on [...]
Righting the Misperceptions of Men Having Sex with Men: A Pre-Requisite for Protecting and Understanding Gender Incongruence in Vietnam
Authors: Nguyen Van , Nguyen Ngoc , Khuat Thu , Nguyen Phuong , Do Thu , Vu Xuan , Tran Kien , Ho Manh , Nguyen Hong , Vuong Thu , Vuong Quan
Published: January 2019

Protecting the rights of the lesbians, gays, bisexuals, transgender, intersex, and queers (LGBTIQ) population requires, first and foremost, a proper understanding of their sexual orientation and gender identity. This study highlights a severe misunderstanding and lack of knowledge among health professionals in Vietnam with regard to the men who have sex with men (MSM) and transgenders. This study uses (i) a survey based on the convenience sampling method among 150 health workers that covered 61 questions and (ii) 12 in-depth interviews in two metropolitan centres in Vietnam, Hanoi and Ho Chi Minh city. Three main topics are explored: (i) the general knowledge of healthcare workers about MSM and transgenders; (ii) their knowledge about the sexual reproductive health and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) risks of MSM and transgenders; and (iii) their attitudes and behaviors towards MSM and transgenders. One of the notable findings is how prevalent the misperceptions are across the board, namely, in staff of both sexes, in both cities, at various kinds of medical facilities, at different work positions and educational levels. Half of the respondents consider transgenders to have a curable mental problem while 45% say MSM only have sex with males. Most remarkably, 12.7% state if they have any choice, they want nothing to do with MSM and transgenders. The study finds there is a considerable percentage of health professionals who lack knowledge about the diversity of sexual orientation, gender identity, and health issues related to the sexual minorities and gender non-conforming population. To improve the clinical process for serving these at-risk groups, the study suggests the continual education for the health workers needs to be added to their formal as well as in-job training.
Effect of Statin Therapy on Arterial Wall Inflammation Based on 18F-FDG PET/CT: A Systematic Review and Meta-Analysis of Interventional Studies
Authors: Pirro Matteo , Simental-Mendía Luis E. , Bianconi Vanessa , Watts Gerald F. , Banach Maciej , Sahebkar Amirhossein
Published: January 2019

Aim. To evaluate by meta-analysis of interventional studies the effect of statin therapy on arterial wall inflammation. Background. Arterial exposure to low-density lipoprotein (LDL) cholesterol levels is responsible for initiation and progression of atherosclerosis and arterial wall inflammation. 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (18F-FDG PET/CT) has been used to detect arterial wall inflammation and monitor the vascular anti-inflammatory effects of lipid-lowering therapy. Despite a number of statin-based interventional studies exploring 18F-FDG uptake, these trials have produced inconsistent results. Methods. Trials with at least one statin treatment arm were searched in PubMed-Medline, SCOPUS, ISI Web of Knowledge, and Google Scholar databases. Target-to-background ratio (TBR), an indicator of blood-corrected 18F-FDG uptake, was used as the target variable of the statin anti-inflammatory activity. Evaluation of studies biases, a random-effects model with generic inverse variance weighting, and sensitivity analysis were performed for qualitative and quantitative data assessment and synthesis. Subgroup and meta-regression analyses were also performed. Results. Meta-analysis of seven eligible studies, comprising 10 treatment arms with 287 subjects showed a significant reduction of TBR following statin treatment (Weighted Mean Difference (WMD): −0.104, p = 0.002), which was consistent both in high-intensity (WMD: −0.132, p = 0.019) and low-to-moderate intensity statin trials (WMD: −0.069, p = 0.037). Statin dose/duration, plasma cholesterol and C-reactive protein level changes, and baseline TBR did not affect the TBR treatment response to statins. Conclusions. Statins were effective in reducing arterial wall inflammation, as assessed by 18F-FDG PET/CT imaging. Larger clinical trials should clarify whether either cholesterol-lowering or other pleiotropic mechanisms were responsible for this effect.
Limitation of Financial Health Prediction in Companies from Post-Communist Countries
Authors: Csikosova Adriana , Janoskova Maria , Culkova Katarina
Published: January 2019

The financial health of a company can be seen as the ability to maintain a balance against changing conditions in the environment and at the same time in relation to everyone participating in the business. In the evaluation of financial health and prediction of financial problems of the companies, various indexes are used that can serve as input for expert estimation or creation of various models using, for example, multi-dimensional statistical methods. The practical application of the proper method for evaluation of financial health has been analysed in post-communist countries, since they have common historic experiences and economic interests. During the research we followed up the following indexes: Altman model, Taffler model, Springate model, and the index IN, based on multi-dimensional discrimination analysis. From the research results there is obvious a necessity to combine available methods in post-communist countries and at least to eliminate their disadvantages partially. Experiences from prediction models have proved their relatively high prediction ability, but only in perfect conditions, which cannot be affirmed in post-communist countries. The task remains to modify existing indexes to concrete situations and problems of the individual industries in the chosen countries, which have unique conditions for business making.
Developing Professional Communication: The Construction of a Multimodal Understanding of Job Interviews
Authors: Ho Wing Yee Jenifer
Published: January 2019

This article explores how online videos with a pedagogical focus can possibly make an impact on our current language teaching and learning practices. The affordance of videos to create multimodal content that can be shared with the public allows content creators to use a wide range of resources, such as spoken and written language, gestures, screen layout, etc., to create learning environments that can promote an awareness of a multimodal perspective to the understanding of a particular kind of professional communication context, such as job interviews, as illustrated in this article. By analyzing a series of videos on job interviews using multimodal semiotic analysis, I argue that these videos, which I call pedagogical vlogs, are helpful not only in terms of teaching the language skills required for job interviews, but also to help create a multimodal understanding of job interviews through the strategic orchestration of multiple semiotic modes. The popularity of pedagogical vlogs, as well as their affordance to provide lesson content created by the public, offer new possibilities for language teaching and learning, but it has yet only received scant attention from applied linguistics and language education researchers. This article aims to start a dialog on the pedagogical implications of this new form of learning so as to uncover the potentials offered by pedagogical vlogs in education.
Acknowledgement to Reviewers of Logistics in 2018
Authors:   Logistics Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
The Microstructure of GNR and the Mechanical Properties of Biobased PLA/GNR Thermoplastic Vulcanizates with Excellent Toughness
Authors: Xia Mingfeng , Lang Wenchao , Yang Yue , Yu Jihang , Wu Ningjing , Wang Qingguo
Published: January 2019

A series of different contents of glycidyl methacrylate (GMA)-grafted natural rubber (GNR) copolymers were fabricated via green bulk melt-grafting reactions, and super-tough bio-based poly (lactic acid) (PLA)/GNR thermoplastic vulcanizates (TPVs) were achieved by in-situ dynamic vulcanization. Increasing the graft yield, gel fraction, and crosslinking density of GNR vulcanizates effectively improved the ductility of the PLA/GNR TPVs, while prolonging the dynamic vulcanization time and increasing the GMA graft yield led to a notable enhancement in the impact toughness of the PLA/GNR TPVs. PLA/30 wt % GNR TPVs exhibited a significantly increased elongation (410%) and notched impact strength (73.2 kJ/m2), which were 40 and 15 times higher than those of the PLA/30 wt % NR TPVs, respectively. The new bio-based PLA/GNR TPVs offer promise as replacements for petroleum-based polymers in the automotive, 3D printing, and packaging fields.
Influence of Powder Deposition on Powder Bed and Specimen Properties
Authors: Beitz Steffen , Uerlich Roland , Bokelmann Tjorben , Diener Alexander , Vietor Thomas , Kwade Arno
Published: January 2019

Three-dimensional printing used to be a rapid prototyping process, but nowadays it is establishing as an additive manufacturing (AM) process. One of these AM techniques is selective laser sintering (SLS), which most often involves partial melting of the particles and therefore belongs to the category of powder bed fusion processes. Much progress has been made in this field by research on process parameters like laser power, hatch distance, and scanning speed while still lacking a fundamental understanding of the powder deposition and its influence on parts. A critical issue for economic manufacturing is the building time of parts with good mechanical properties, which can be reduced by lower surface roughness due to less or missing post processing. Therefore, the influence of three blade shapes on powder bed surface roughness has been evaluated for PA12 powder with three different grain size distributions by using advanced X-ray micro computed tomography (XMT) and a confocal laser scanning microscope (LSM). Along with those methods, new techniques for powder characterization were tested and compared. Lowest roughness has been achieved with a flat blade, based on a higher compression due to a larger contact zone between blade and powder bed. Furthermore, an anisotropic effect of the mechanical properties resulting from different building directions has been detected which can be explained by varying amounts of solid contact paths through the powder bed depending on powder application direction. In addition, an optimal combination of process parameters with an even compression of the powder bed leads to low surface roughness, complementing the advantages of additive manufacturing.
Shear Performance at Room and High Temperatures of Glass–Ceramic Sealants for Solid Oxide Electrolysis Cell Technology
Authors: Javed Hassan , Sabato Antonio Gianfranco , Dlouhy Ivo , Halasova Martina , Bernardo Enrico , Salvo Milena , Herbrig Kai , Walter Christian , Smeacetto Federico
Published: January 2019

To provide a reliable integration of components within a solid oxide electrolysis cell stack, it is fundamental to evaluate the mechanical properties of the glass–ceramic sealing materials, as well as the stability of the metal–glass–ceramic interface. In this work, the mechanical behavior of two previously developed glass–ceramic sealants joined to Crofer22APU steel is investigated at room temperature, 650 °C, and 850 °C under shear load. The mechanical properties of both the glass–ceramics showed temperature dependence. The shear strength of Crofer22APU/glass–ceramic/Crofer22APU joints ranged from 14.1 MPa (20 °C) to 1.8 MPa (850 °C). The elastic modulus of both glass–ceramics also reduced with temperature. The volume fraction of the crystalline phases in the glass–ceramics was the key factor for controlling the mechanical properties and fracture, especially above the glass-transition temperature.
Ball Comparison for Some Efficient Fourth Order Iterative Methods Under Weak Conditions
Authors: Argyros Ioannis K. , Behl Ramandeep
Published: January 2019

We provide a ball comparison between some 4-order methods to solve nonlinear equations involving Banach space valued operators. We only use hypotheses on the first derivative, as compared to the earlier works where they considered conditions reaching up to 5-order derivative, although these derivatives do not appear in the methods. Hence, we expand the applicability of them. Numerical experiments are used to compare the radii of convergence of these methods.
Resistance Distance in the Double Corona Based on R-Graph
Authors: Zhang Li , Zhao Jing , Liu Jia-Bao , Daoud Salama Nagy
Published: January 2019

Let G 0 be a connected graph on n vertices and m edges. The R-graph R ( G 0 ) of G 0 is a graph obtained from G 0 by adding a new vertex corresponding to each edge of G 0 and by joining each new vertex to the end points of the edge corresponding to it. Let G 1 and G 2 be graphs on n 1 and n 2 vertices, respectively. The R-graph double corona G 0 ( R ) ∘ { G 1 , G 2 } of G 0 , G 1 and G 2 , is the graph obtained by taking one copy of R ( G 0 ) , n copies of G 1 and m copies of G 2 and then by joining the i-th old-vertex of R ( G 0 ) to every vertex of the i-th copy of G 1 and the j-th new vertex of R ( G 0 ) to every vertex of the j-th copy of G 2 . In this paper, we consider resistance distance in G 0 ( R ) ∘ { G 1 , G 2 } . Moreover, we give an example to illustrate the correction and efficiency of the proposed method.
Improved Convergence Analysis of Gauss-Newton-Secant Method for Solving Nonlinear Least Squares Problems
Authors: Argyros Ioannis , Shakhno Stepan , Shunkin Yurii
Published: January 2019

We study an iterative differential-difference method for solving nonlinear least squares problems, which uses, instead of the Jacobian, the sum of derivative of differentiable parts of operator and divided difference of nondifferentiable parts. Moreover, we introduce a method that uses the derivative of differentiable parts instead of the Jacobian. Results that establish the conditions of convergence, radius and the convergence order of the proposed methods in earlier work are presented. The numerical examples illustrate the theoretical results.
Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging
Authors: Hyun Yu Jae , Piao Mei Jing , Kang Kyoung Ah , Zhen Ao Xuan , Madushan Fernando Pincha Devage Sameera , Kang Hee Kyoung , Ahn Yong Seok , Hyun Jin Won
Published: January 2019

Skin is exposed to various harmful environmental factors such as air pollution, which includes different types of particulate matter (PM). Atmospheric PM has harmful effects on humans through increasing the generation of reactive oxygen species (ROS), which have been reported to promote skin aging via the induction of matrix metalloproteinases (MMPs), which in turn can cause the degradation of collagen. In this study, we investigated the effect of fermented fish oil (FFO) derived from mackerel on fine PM (particles with a diameter < 2.5 µm: PM2.5)-induced skin aging in human keratinocytes. We found that FFO inhibited the PM2.5-induced generation of intracellular ROS and MMPs, including MMP-1, MMP-2, and MMP-9. In addition, FFO significantly abrogated the elevation of intracellular Ca2+ levels in PM2.5-treated cells and was also found to block the PM2.5-induced mitogen-activated protein kinase/activator protein 1 (MAPK/AP-1) pathway. In conclusion, FFO has an anti-aging effect on PM2.5-induced aging in human keratinocytes.
Identification of Prognostic Biomarker Signatures and Candidate Drugs in Colorectal Cancer: Insights from Systems Biology Analysis
Authors: Rahman Md. Rezanur , Islam Tania , Gov Esra , Turanli Beste , Gulfidan Gizem , Shahjaman Md. , Akhter Banu Nilufa , Mollah Md. Nurul Haque , Arga Kazim Yalcin , Moni Mohammad Ali
Published: January 2019

Background and objectives: Colorectal cancer (CRC) is the second most common cause of cancer-related death in the world, but early diagnosis ameliorates the survival of CRC. This report aimed to identify molecular biomarker signatures in CRC. Materials and Methods: We analyzed two microarray datasets (GSE35279 and GSE21815) from the Gene Expression Omnibus (GEO) to identify mutual differentially expressed genes (DEGs). We integrated DEGs with protein–protein interaction and transcriptional/post-transcriptional regulatory networks to identify reporter signaling and regulatory molecules; utilized functional overrepresentation and pathway enrichment analyses to elucidate their roles in biological processes and molecular pathways; performed survival analyses to evaluate their prognostic performance; and applied drug repositioning analyses through Connectivity Map (CMap) and geneXpharma tools to hypothesize possible drug candidates targeting reporter molecules. Results: A total of 727 upregulated and 99 downregulated DEGs were detected. The PI3K/Akt signaling, Wnt signaling, extracellular matrix (ECM) interaction, and cell cycle were identified as significantly enriched pathways. Ten hub proteins (ADNP, CCND1, CD44, CDK4, CEBPB, CENPA, CENPH, CENPN, MYC, and RFC2), 10 transcription factors (ETS1, ESR1, GATA1, GATA2, GATA3, AR, YBX1, FOXP3, E2F4, and PRDM14) and two microRNAs (miRNAs) (miR-193b-3p and miR-615-3p) were detected as reporter molecules. The survival analyses through Kaplan–Meier curves indicated remarkable performance of reporter molecules in the estimation of survival probability in CRC patients. In addition, several drug candidates including anti-neoplastic and immunomodulating agents were repositioned. Conclusions: This study presents biomarker signatures at protein and RNA levels with prognostic capability in CRC. We think that the molecular signatures and candidate drugs presented in this study might be useful in future studies indenting the development of accurate diagnostic and/or prognostic biomarker screens and efficient therapeutic strategies in CRC.
Extent and Predictors of Poor Glycaemic Control among Elderly Pakistani Patients with Type 2 Diabetes Mellitus: A Multi-Centre Cross-Sectional Study
Authors: Atif Muhammad , Saleem Quratulain , Asghar Saima , Malik Iram , Ahmad Nafees
Published: January 2019

Objectives: This study aimed to explore the relationship between glycaemic control and factors that may influence this among elderly type 2 diabetes mellitus (T2DM) patients in Lahore, Pakistan. Methods: This descriptive, cross-sectional study was conducted at the Jinnah and Sir Ganga Ram Hospitals, Lahore using convenience sampling techniques between 1 December 2015 and 28 February 2016. The sample consisted of elderly (>65 years) T2DM patients. Glycaemic values and patient characteristics were obtained from medical charts. Consenting patients were interviewed to complete the Barthel Index, Lawton Instrumental Activities of Daily Living Scale, Clinical Frailty Scale, Iowa Pain Thermometer Scale, Geriatric Depression Scale, Montreal Cognitive Assessment tool, Mini Nutritional Assessment Scale—Short Form and Self Care Inventory—Revised Version. Multiple logistic regression analysis was carried out to determine the predictors of poor glycaemic control. Results: A total of 490 patients were approached and 400 agreed to participate. Overall, nearly one-third (32.2%, n = 129) of patients had glycated haemoglobin (HbA1c) at the target level. Fasting and random plasma glucose levels were within the target range to much the same extent; (36.8%, n = 147) and (27%, n = 108), respectively. HbA1c levels were also higher in patients with co-morbidities (67.4%, n = 229) with diabetes-related complications (73.5%, n = 227). Significant predictors of impaired glycaemic control (HbA1c) included poor diabetes self-care (adjusted odds ratio (AOR) 0.96; 95% confidence interval (CI) 0.95, 0.98), not being prescribed oral hypoglycaemic agents (OHA) (AOR 6.22; 95% CI 2.09, 18.46), regular hypoglycaemic attacks (AOR 2.53; 95% CI 1.34, 4.81) and falling tendency (AOR 0.19; 95% CI 0.10, 0.36). Conclusions: Poor glycaemic control prevailed among the majority of elderly Pakistani diabetic patients in this study. Triggering factors of poor glycaemic control should be taken into consideration by the healthcare professionals in targeting multifaceted interventions to achieve good glycaemic control.
Current Status and Major Challenges to the Safety and Efficacy Presented by Chinese Herbal Medicine
Authors: Zhou Xian , Li Chun-Guang , Chang Dennis , Bensoussan Alan
Published: January 2019

Traditional Chinese medicine (TCM) is not only used prevalently in Asian countries but has also gained a stable market globally. As a principal form of TCM, Chinese herbal medicine (CHM) is comprised of treatments using multiple Chinese herbs which have complex chemical profiles. Due to a lack of understanding of its modality and a lack of standardization, there are significant challenges associated with regulating CHM’s safety for practice and understanding its mechanisms of efficacy. Currently, there are many issues that need to be overcome in regard to the safety and efficacy of CHM for the further development of evidence-based practices. There is a need to better understand the mechanisms behind the efficacy of CHM, and develop proper quality standards and regulations to ensure a similar safety standard as Western drugs. This paper outlines the status of CHM in terms of its safety and efficacy and attempts to provide approaches to address these issues.
A-242 Aluminium Alloy Foams Manufacture from the Recycling of Beverage Cans
Authors: Trejo Rivera Nallely Montserrat , Torres Torres Jesús , Flores Valdés Alfredo
Published: January 2019

This paper presents and discusses a methodology implemented to study the process of the preparation of aluminium alloy foams using the alloy A-242, beginning from the recycling of secondary aluminium obtained from beverage cans. The foams are prepared by a melting process by adding 0.50 wt.% calcium to the A-242 aluminium alloy with the aim to change its viscosity in the molten state. To obtain the foam, titanium hydride is added in different concentrations (0.50 wt.%, 0.75 wt.%, and 1.00 wt.%) and at different temperatures (923, 948 K, and 973 K) while the foaming time is kept constant at 30 s. For a set of experimental parameter values, aluminium alloy foams with the average relative density of 0.12 were obtained and had an 88.22% average porosity. In this way, it is possible to state that the preparation of aluminium alloy foams A-242 processed from the recycling of cans is possible, with characteristics and properties similar to those obtained using commercial-purity metals.
Fe–Si–Al Coatings with Stable Wear Resistance Prepared by Laser Cladding Industrial Wastes
Authors: Liu Xue , Ma Bin-Bin , Hu Li-Wei , Li Jin-Feng , Qu Feng-Sheng , Le Guo-Min , Li Xiu-Yan
Published: January 2019

Because wear is one of the most common reasons for the failure of metals, the development of a low-cost coating with enhanced wear resistance is of great importance. In the present study, Fe–Si–Al coatings with superior and stable wear resistance were prepared by laser cladding Fe–Si–Al industrial waste onto 1045 carbon steel. The microstructure, as well as the wear mechanism of the Fe–Si–Al coatings, was investigated. The Fe–Si–Al coatings consist of a (Al, Fe, Si) solid solution phase in both columnar grain form and equiaxed grain form. The Fe–Si–Al coatings possess enhanced microhardness of 494 ± 15 HV0.3 and low mass loss of 5 × 10−5 mg·(N·m)−1. The wear resistance is ten times higher than that of the 1045 carbon steel matrix. The wear of the Fe–Si–Al coatings is mainly dominated by abrasive wear and adhesive wear. This work provides important insight into the preparation of low-cost, wear-resistant coatings, as well as stable, superior wear resistance.
Low Cycle Fatigue and Relaxation Performance of Ferritic–Martensitic Grade P92 Steel
Authors: Jürgens Maria , Olbricht Jürgen , Fedelich Bernard , Skrotzki Birgit
Published: January 2019

Due to their excellent creep resistance and good oxidation resistance, 9–12% Cr ferritic–martensitic stainless steels are widely used as high temperature construction materials in power plants. However, the mutual combination of different loadings (e.g., creep and fatigue), due to a “flexible” operation of power plants, may seriously reduce the lifetimes of the respective components. In the present study, low cycle fatigue (LCF) and relaxation fatigue (RF) tests performed on grade P92 helped to understand the behavior of ferritic–martensitic steels under a combined loading. The softening and lifetime behavior strongly depend on the temperature and total strain range. Especially at small strain amplitudes, the lifetime is seriously reduced when adding a hold time which indicates the importance of considering technically relevant small strains.