bluuebunny/crossref_metadata_2025 huggingface dataset:
Chloride and Potassium Assessment Is a Helpful Tool for Differential Diagnosis of Thiazide-Associated Hyponatremia
Authors: Potasso Laura , Monnerat Sophie , Refardt Julie , Lindner Gregor , Burst Volker , Winzeler Bettina , Christ-Crain Mirjam
Published: March 2023

Context

Differential diagnosis of thiazide-associated hyponatremia (TAH) is challenging. Patients can either have volume depletion or a syndrome of inappropriate antidiuresis (SIAD)-like presentation.

Objective

To evaluate the impact of the simplified apparent strong ion difference in serum (aSID; sodium + potassium − chloride) as well as the urine chloride and potassium score (ChU; chloride − potassium in urine) in the differential diagnosis of TAH, in addition to assessment of fractional uric acid excretion (FUA).

Methods

Post hoc analysis of prospectively collected data from June 2011 to August 2013 from 98 hospitalized patients with TAH < 125 mmol/L enrolled at University Hospital Basel and University Medical Clinic Aarau, Switzerland. Patients were categorized according to treatment response in volume-depleted TAH requiring volume substitution or SIAD-like TAH requiring fluid restriction. We computed sensitivity analyses with ROC curves for positive predictive value (PPV) and negative predictive value (NPV) of aSID, ChU, and FUA in differential diagnosis of TAH.

Results

An aSID > 42 mmol/L had a PPV of 79.1% in identifying patients with volume-depleted TAH, whereas a value < 39 mmol/L excluded it with a NPV of 76.5%. In patients for whom aSID was inconclusive, a ChU < 15 mmol/L had a PPV of 100% and a NPV of 83.3%, whereas FUA < 12% had a PPV of 85.7% and a NPV of 64.3% in identifying patients with volume-depleted TAH.

Conclusion

In patients with TAH, assessment of aSID, potassium, and chloride in urine can help identifying patients with volume-depleted TAH requiring fluid substitution vs patients with SIAD-like TAH requiring fluid restriction.
Thyroid Cancer, Neuroendocrine Tumor, Adrenal Adenoma, and Other Tumors in a Patient With a Germline PMS1 Mutation
Authors: Alghamdi Balgees , Al-Hindi Hindi , Murugan Avaniyapuram Kannan , Alzahrani Ali S
Published: March 2023

Context

Multiple tumors in the same patient suggest a genetic predisposition. Here, we report a patient who presented with several unusual types of malignant and benign tumors, presumably due to a pathogenic germline PMS1 mutation.

Case

A 69-year-old woman presented with a 2-year history of abdominal pain and diarrhea. A computed tomography scan of the abdomen revealed a gastrointestinal neuroendocrine tumor (GiNET) with liver metastases and a nonfunctional benign adrenal adenoma. Bilateral large lung nodules were thought to be also metastases from the GiNET but turned out to be differentiated thyroid cancer metastases, which later progressed to anaplastic thyroid cancer (ATC) and led to the patient's demise. A right sphenoid wing meningioma causing partial hypopituitarism was diagnosed during her evaluation. A mammogram and a breast ultrasound revealed a 0.3-cm left breast nodule. Due to the multiplicity of her tumors, whole exome sequencing was performed. This revealed a previously described PMS1 deletion mutation causing a frameshift and truncation (NM_000534c.1258delC, p.His420Ilefs*22) but no other pathogenic variant in other cancer genes. DNA isolated from the ATC tumor tissue showed loss of heterozygosity of the same mutation, highly suggestive of its pathogenic role in thyroid cancer and presumably other tumors.

Conclusion

This case reports several tumors including thyroid cancer, GiNET, adrenal adenoma, meningioma, and breast nodule, likely due to the PMS1 mutation found in this patient.
Recovery of visual function after endarterectomy - series of cases report
Authors: Krasińska-Płachta Aleksandra , Brązert Agata , Mamczur-Załęcka Joanna , Begier-Krasińska Beata , Krasiński Zbigniew , Kocięcki Jarosław
Published: March 2023

Carotid arteriosclerosis is the main cause of the stroke but it can also lead to ophthalmic symptoms. In this article, we aim to present four patients. All of them had hemodynamically significant but asymptomatic unilateral carotid stenosis and underwent internal carotid endarterectomy. Postoperatively, their visual function improved. Mean deviation in perimetry and values of amplitudes in pattern visual evoked potentials increased. Two patients improved visual acuity; in the other two, it remained stable.
ORTAK HİKÂYE DAYANAN İKİ ÇORUM TÜRKÜSÜ ÜZERİNE BİR İNCELEME
Authors: SATIR Ömer Can , ORTAKCI Altuğ
Published: March 2023

Bu çalışma Ankara Devlet Konservatuvarı’nın 1939 yılında Çorum’dan derlediği iki ağıt türkünün incelenmesi üzerinedir. İlk türkü Alacahöyük’ten derlenen ve “Mehmet Ağıtı” ismiyle kaydedilen ancak bugün daha çok “Hem okudum hemi de yazdım” ismiyle bilinen türküdür. İkincisi ise Osmancık’tan derlenen ve “Hacı Hamza” ismiyle kaydedilen, bugün daha çok “El veriyor el veriyor” ismiyle tanınan türküdür. Çorum yöresinde çeşitlenerek varyantlar oluşturan bu türkülerin öncelikle hikâyeleri değerlendirilmiş akabinde söz konusu türküler biçimsel analiz ve müzikal yapı bağlamında ele alınmıştır. Türkülerin biçimsel edebi analizinde kafiye ve redif unsurları, vezin-durak sistemi ve bent yapısı üzerinden bir değerlendirme yapılırken metne ait veri setleri derleme fişleri ile TRT’nin yayımladığı notalardan alınmıştır. Müzikal çözümleme ise Türk müziğinin temeli olan makam ve usul paradigması üzerinden gerçekleşmiştir. Düzen-perde-seyir üçgeninde ele alınan her iki türkünün benzeşen ve ayrışan yönleri ezgi organizasyonu temelinde değerlendirmeye açılırken halk müziği ürünlerinde güncel bir sorun olan ritmik yapı organizasyonları halk müziğine getirilen yeni usul yaklaşımı referansıyla tanımlanmıştır. Sözlü kültür ortamında yaratılan ve toplum hafızasında kolektif bellek nesnesine dönüşen türkülerin farklı zaman ve zeminlerdeki aktarımı sırasında yaşadığı varyantlaşma sürecinde ortaya çıkan farklılıklar özellikle yöre diline uygun ifade biçimlerinde kendisini göstermektedir. Müzikal bağlamda ise yöre karakteri bakımından tarihi makam geleneğinden izler taşıyan ses evreniyle çevrelenmesi ağıt türkülerin zaman-mekân birlikteliğindeki derin ve yaygın özelliğini gözler önüne sermektedir.
SOMUT OLMAYAN KÜLTÜREL MİRAS SÖZLÜ GELENEK VE ANLATIMLAR TUTUM ÖLÇEĞİ GELİŞTİRME ÇALIŞMASI
Authors: ER Züleyha , KARAKUŞ Neslihan
Published: March 2023

Dil kültürün taşıyıcısı, kültür dilin hazinesidir. Dil sayesinde kültürel miras kuşaktan kuşağa aktarılmıştır. Teknolojinin hızla gelişimi ve modern dünya düzeni gibi bazı sebepler kültürel mirasın ötelenmesine sebep olmuştur. Somut olmayan kültürel miras toplum için kıymetlidir. Zarar görmesi, yitirilmesi toplumun geleceğini olumsuz yönde etkileyecektir. Somut olmayan kültürel mirasımızın genç kuşaklara aktarımı oldukça önemlidir. Ana dil öğretimi dersi olan Türkçe dersinin amaçları arasında kültürel mirasımızın aktarımının önemine değinilmiştir. Bu doğrultuda, bu çalışmada ortaokul öğrencileri için Somut Olmayan Kültürel Miras Tutum Ölçeği geliştirilmiştir. 30 maddelik ölçek, öğrencilerin yaşları ve bilişsel hazır bulunuşlukları dikkate alınarak 4 seçenekli, Likert tipinde tasarlanmıştır. Çalışmaya 187 kız ve 168 erkek olmak üzere toplam 355 ortaokul öğrencisi katılmıştır. Somut Olmayan Kültürel Miras Tutum Ölçeğinin geçerlik ve güvenirlik analizleri için SPSS 26.0 ve AMOS 24.0 programlarından yararlanılmıştır. Somut Olmayan Kültürel Miras Tutum Ölçeğinin geneli ve üç faktörü arasında da pozitif yönde ve anlamlı (p
YEMEK VE BELLEK İLİŞKİSİNDEN HAREKETLE ŞEMSİ YASTIMAN’IN MEMLEKET HASRETİ ŞİİRİNDE GASTRONOSTALJİ
Authors: ALPYILDIZ Eray
Published: March 2023

Yemek, bireysel ve kolektif belleğin nasıl inşa edildiğinin kodlarını taşıyan fizyolojik ve kültürel bir bileşendir. İnsan boğazından giren lokmaların duyu organları aracılığıyla tanımlanması belleğin psiko-fizyolojik düzeyde genellikle bireysel boyutunu ortaya çıkarsa da fizyolojik faktörlerin sosyal ve kültürel bağlamlar içerisindeki deneyimlerle de kolektif belleğin inşasında rolü bulunmaktadır. Yemek, çocukluktan itibaren sosyalleşme ve kültürlenme eksenindeki bir yaşam içerisinde sembolik anlamların tanımlanmasında, sosyal ilişkilerin çerçevelendirilmesinde ve kültürel olarak öğrenilmiş davranışlar dizisinin yansıtılmasında önemli bir zemin ve başat bir öğedir. Bu doğrultuda belleğin inşasındaki ayırt edici işleviyle yemek, hatırlamanın (ve hatıraların) da kaynağı olmaktadır. Bu hatırlama ise genellikle yiyeceği hatırlama ve yiyerek hatırlama şeklinde kendisini göstermektedir. Bu bağlamda yemek ve bellek ilişkisine dair yaklaşımlar içerisinde bu uyumlu mekanizmanın alt alanı olarak tanımlayabileceğimiz yemek merkezli nostalji ya da son dönemde literatürdeki adıyla gastronostalji kavramı dikkat çekmektedir. Bu çalışmada yemek ve bellek ilişkisinden hareketle yemeğin nostaljisi veya gastronostalji yaklaşımı, Kırşehirli Âşık Şemsi Yastıman tarafından tadı damağında bir geçmişin izleri sürülerek ortaya çıkarılan Memleket Hasreti destanı özeli veya örneğinde çözümlenmiştir. Farklı bir ifadeyle yemeğin, bireysel ve kolektif belleği oluşturan boyutu, bu eser örneğinde incelenmiştir. Bununla birlikte kültürel anlamda pek çok açıdan ağır basan bu şiir etrafında farklı konuların çözümlemeleri de yapılmıştır. Bu doğrultuda âşıklık geleneği ve göç ilişkisine dair birtakım değerlendirmelerin ardından kent yaşamının ortaya çıkardığı sorunlar üzerinde durulmuştur. Kısaca bu çalışmada yemek ve bellek ilişkisinin bir yansıması olarak gastronostalji veya yemeğin nostaljisi olarak nitelendirilen alanın, yemekle ilgili hatıralar toplamından fazlası olduğu vurgulanmıştır.
Exploring the reasons for labour market gender inequality a year into the COVID-19 pandemic: evidence from the UK cohort studies
Authors: Wielgoszewska Bożena , Bryson Alex , Costa Dias Monica , Foliano Francesca , Joshi Heather , Wilkinson David
Published: March 2023

The COVID-19 pandemic has caused unexpected disruptions to Western countries which affected women more adversely than men. Previous studies suggest that gender differences are attributable to: women being over-represented in the most affected sectors of the economy, women’s labour market disadvantage as compared to their partners, and mothers taking a bigger share childcare responsibilities following school closures. Using the data from four British nationally representative cohort studies, we test these propositions. Our findings confirm that the adverse labour market effects were still experienced by women a year into the COVID-19 pandemic and that these effects were the most severe for women who lived with a partner and children, even if they worked in critical occupations. We show that adjusting for pre-pandemic job characteristics attenuates the gaps, suggesting that women were over-represented in jobs disproportionately affected by COVID-19 pandemic. However, the remaining gaps are not further attenuated by adjusting for the partner’s job and children characteristics, suggesting that the adversities experienced by women were not driven by their relative labour market position, as compared to their partners or childcare responsibilities. The residual gender differences observed in the rates of active, paid work and furlough for those who live with partner and children point to the importance of unobserved factors such as social norms, preferences, or discrimination. These effects may be long-lasting and jeopardise women’s longer-term position through the loss of experience, leading to reinforcement of gender inequalities or even reversal of the progress towards gender equality.
Uso de dados aeromagnéticos e eletromagnéticos na avaliação de estruturas condicionadoras de aquíferos fraturados e produtividade dos poços, no Sistema Aquífero Embasamento Cristalino, na região de Bagé (RS)
Authors: Dessart Rafael Lima , Reginato Pedro Antonio Roehe , Gallas José Domingos Faraco
Published: March 2023

Esse artigo apresenta o estudo de avaliação do comportamento hidrogeológico do Sistema Aquífero Embasamento Cristalino, no município de Bagé (RS) que é uma região que passa por períodos recorrentes de estiagem, afetando o abastecimento e a agricultura. Uma das soluções encontradas para sanar este problema é a perfuração de poços tubulares. No município de Bagé ocorre um sistema aquífero fraturado, onde a locação de poços produtivos se torna mais complexa e a compreensão dos fatores que condicionam o sistema e o fluxo da água subterrânea se torna muito importante. Para atingir este objetivo foi realizada uma análise dos dados hidrogeológicos de 174 poços tubulares, processamento dos dados aeromagnéticos e caminhamentos eletromagnéticos. Para realizar a avaliação estrutural da área, foram identificados lineamentos magnéticos por meio da utilização dos diversos filtros, métodos de realce nos dados aeromagnéticos, disponíveis para o software Oasis Montaj da Geosoft. Também foi realizado coleta de campo de dados eletromagnéticos, com o equipamento o EM34 modelo XL da Geonics com o objetivo de confirmar e validar os dados dos lineamentos aeromagnéticos interpretados, sendo realizados 8 perfis de caminhamento eletromagnético. Os resultados obtidos mostram que os aquíferos fraturados na região do município de Bagé se apresentam compartimentados, com diferentes produtividades e trends estruturais. As principais estruturas aquíferas ocorrem na direção NW, secundariamente para NE, e com uma acentuação de sua produtividade quando associado a cruzamentos de estruturas, tanto para NW como NE. A interpretação integrada dos dados aéreos e terrestres permitiu reconhecer o comportamento hidrogeológico e estrutural do Sistema Aquífero Embasamento Cristalino, onde os resultados, apresentados em mapas georreferenciados, apresentam as principais zonas e trends que estão associados a aquíferos fraturados.
Pengamatan Morfologi Bagian Tanaman Lima Kultivar Kedelai [Glycine max (L.) Merrill]
Authors: Sumarmi S , Triyono Kharis
Published: March 2023

Written descriptions of soybean plants often have different results after planting. Not much has been done to observe the morphology of the anthers of various soybean cultivars. Not much has been done to observe the morphology of the anthers of various soybean cultivars. This study aims to observe the morphological characteristics of five soybean cultivars.  The research was conducted in the research field and plant laboratory at the Faculty of Agriculture, Universitas  Slamet Riyadi, Surakarta, using a completely randomized design. Five soybean cultivars were planted namely Argomulyo, Grobogan, Wilis, Anjasmoro and Hitam Malika. Observations on the seeds used, plant height growth, leaf morphology, flower morphology and anther conditions. Argomulyo, Grobogan and Anjasmoro cultivars have large seeds, weighing 100 seeds between 15-18 grams. Plant height growth occurs until the plant is 5 weeks old. The color and shape of the leaves of five one-month-old soybean cultivars are almost the same. At the beginning of the 2nd month, the leaves of the soybean plants turned dark green, which was evident in Grobogan and Hitam Malika cultivars. The crown color of the Black Malika soybean flower is dark purple, different from the other 4 cultivars with purple flowers. Cultivar Anjasmoro, 5 weeks old, reached 63 cm, the highest among the five cultivars planted. Each soybean cultivar has morphological characteristics in terms of plant height, shape, leaf color, flowers, pods, seeds and or anthers.
Food readjustment plus exercise training improves cardiovascular autonomic control and baroreflex sensitivity in high‐fat diet‐fed ovariectomized mice
Authors: Nascimento‐Carvalho Bruno , Dos‐Santos Adriano , Da Costa‐Santos Nicolas , Carvalho Sabrina L. , de Moraes Oscar A. , Santos Camila P. , De Angelis Katia , Caperuto Erico C. , Irigoyen Maria‐Claudia , Scapini Katia B. , Sanches Iris C.
Published: March 2023

Despite consensus on the benefits of food readjustment and/or moderate‐intensity continuous exercise in the treatment of cardiometabolic risk factors, there is little evidence of the association between these two cardiovascular risk management strategies after menopause. Thus, the objective of this study was to evaluate the effects of food readjustment and/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet‐induced obesity. Forty C57BL/6J ovariectomized mice were divided into the following groups: high‐fat diet‐fed ‐ 60% lipids throughout the protocol (HF), food readjustment ‐ 60% lipids for 5 weeks, readjusted to 10% for the next 5 weeks (FR), high‐fat diet‐fed undergoing moderate‐intensity exercise training (HFT), and food readjustment associated with moderate‐intensity exercise training (FRT). Blood glucose evaluations and oral glucose tolerance tests were performed. Blood pressure was assessed by direct intra‐arterial measurement. Baroreflex sensitivity was tested using heart rate phenylephrine and sodium nitroprusside induced blood pressure changes. Cardiovascular autonomic modulation was evaluated in time and frequency domains. Inflammatory profile was evaluated by IL‐6, IL‐10 cytokines, and TNF‐alpha measurements. Only the exercise training associated with food readjustment strategy induced improved functional capacity, body composition, metabolic parameters, inflammatory profile, and resting bradycardia, while positively changing cardiovascular autonomic modulation and increasing baroreflex sensitivity. Our findings demonstrate that the association of these strategies seems to be effective in the management of cardiometabolic risk in a model of loss of ovarian function with diet‐induced obesity.
Short‐term semaglutide treatment improves FGF21 responsiveness in primary hepatocytes isolated from high fat diet challenged mice
Authors: Feng Jia Nuo , Shao Weijuan , Jin Tianru
Published: March 2023

Metabolic functions of GLP‐1 and its analogues have been extensively investigated. In addition to acting as an incretin and reducing body weight, we and others have suggested the existence of GLP‐1/fibroblast growth factor 21 (FGF21) axis in which liver mediates certain functions of GLP‐1 receptor agonists. In a more recent study, we found with surprise that four‐week treatment with liraglutide but not semaglutide stimulated hepatic FGF21 expression in HFD‐challenged mice. We wondered whether semaglutide can also improve FGF21 sensitivity or responsiveness and hence triggers the feedback loop in attenuating its stimulation on hepatic FGF21 expression after a long‐term treatment. Here, we assessed effect of daily semaglutide treatment in HFD‐fed mice for 7 days. HFD challenge attenuated effect of FGF21 treatment on its downstream events in mouse primary hepatocytes, which can be restored by 7‐day semaglutide treatment. In mouse liver, 7‐day semaglutide treatment stimulated FGF21 as well as genes that encode its receptor (FGFR1) and the obligatory co‐receptor (KLB), and a battery of genes that are involved in lipid homeostasis. In epididymal fat tissue, expressions of a battery genes including Klb affected by HFD challenge were reversed by 7‐day semaglutide treatment. We suggest that semaglutide treatment improves FGF21 sensitivity which is attenuated by HFD challenge.
Central angiotensin 1–7 triggers brown fat thermogenesis
Authors: Evangelista F. S. , Bartness T. J.
Published: March 2023

We tested the hypothesis that third ventricular (3V) injections of angiotensin 1–7 (Ang 1–7) increases thermogenesis in brown adipose tissue (BAT), and whether the Mas receptor mediates this response. First, in male Siberian hamsters (n = 18), we evaluated the effect of Ang 1–7 in the interscapular BAT (IBAT) temperature and, using selective Mas receptor antagonist A‐779, the role of Mas receptor in this response. Each animal received 3V injections (200 nL), with 48 h intervals: saline; Ang 1–7 (0.03, 0.3, 3, and 30 nmol); A‐779 (3 nmol); and Ang 1–7 (0.3 nmol) + A‐779 (3 nmol). IBAT temperature increased after 0.3 nmol Ang 1–7 compared with Ang 1–7 + A‐779 at 20, 30, and 60 min. Also, 0.3 nmol Ang 1–7 increased IBAT temperature at 10 and 20 min, and decreased at 60 min compared with pretreatment. IBAT temperature decreased after A‐779 at 60 min and after Ang 1–7 + A‐779 at 30 and 60 min compared with the respective pretreatment. A‐779 and Ang 1–7 + A‐779 decreased core temperature at 60 min compared with 10 min. Then, we evaluated blood and tissue Ang 1–7 levels, and the expression of hormone‐sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) in IBAT. Male Siberian hamsters (n = 36) were killed 10 min after one of the injections. No changes were observed in blood glucose, serum and IBAT Ang 1–7 levels, and ATGL. Ang 1–7 (0.3 nmol) increased p‐HSL expression compared with A‐779 and increased p‐HSL/HSL ration compared with other injections. Ang 1–7 and Mas receptor immunoreactive cells were found in brain regions that coincide with the sympathetic nerves outflow to BAT. In conclusion, 3V injection of Ang 1–7 induced thermogenesis in IBAT in a Mas receptor‐dependent manner.
Associations of atrial natriuretic peptide with measures of insulin and adipose depots
Authors: Couch Catharine A. , Fowler Lauren A. , Parcha Vibhu , Arora Pankaj , Gower Barbara A.
Published: March 2023

Low concentrations of natriuretic peptides (NPs) have been associated with greater risk for Type 2 diabetes (T2D). African American individuals (AA) have lower NP levels and are disproportionately burdened by T2D. The purpose of this study was to test the hypothesis that higher post‐challenge insulin in AA adults is associated with lower plasma N‐terminal pro‐atrial natriuretic peptide (NT‐proANP). A secondary purpose was to explore associations between NT‐proANP and adipose depots. Participants were 112 AA and European American (EA) adult men and women. Measures of insulin were obtained from an oral glucose tolerance test and hyperinsulinemic‐euglycemic glucose clamp. Total and regional adipose depots were measured from DXA and MRI. Multiple linear regression analysis was used to assess associations of NT‐proANP with measures of insulin and adipose depots. Lower NT‐proANP concentrations in AA participants was not independent of 30‐min insulin area under the curve (AUC). NT‐proANP was inversely associated with 30‐min insulin AUC in AA participants, and with fasting insulin and HOMA‐IR in EA participants. Thigh subcutaneous adipose tissue and perimuscular adipose tissue were positively associated with NT‐proANP in EA participants. Higher post‐challenge insulin may contribute to lower ANP concentrations in AA adults.
Muscle sympathetic nerve activity during pregnancy: A systematic review and meta‐analysis
Authors: Greenwall Kelly M. , Brislane Áine , Matenchuk Brittany A. , Sivak Allison , Davenport Margie H. , Steinback Craig D.
Published: March 2023

We conducted a systematic review and meta‐analysis to quantify the impact of healthy and complex pregnancy on muscle sympathetic nerve activity (MSNA) at rest, and in response to stress. Structured searches of electronic databases were performed until February 23, 2022. All study designs (except reviews) were included: population (pregnant individuals); exposures (healthy and complicated pregnancy with direct measures of MSNA); comparator (individuals who were not pregnant, or with uncomplicated pregnancy); and outcomes (MSNA, BP, and heart rate). Twenty‐seven studies (N = 807) were included. MSNA burst frequency was higher in pregnancy (n = 201) versus non‐pregnant controls (n = 194) (Mean Differences [MD], MD: 10.6 bursts/min; 95% CI: 7.2, 14.0; I2 = 72%). Accounting for the normative increase in heart rate with gestation, burst incidence was also higher during pregnancy (Pregnant N = 189, non‐pregnant N = 173; MD: 11 bpm; 95% CI: 8, 13 bpm; I2 = 47%; p < 0.0001). Meta‐regression analyses confirmed that although sympathetic burst frequency and incidence are augmented during pregnancy, this was not significantly associated with gestational age. Compared to uncomplicated pregnancy, individuals with obesity, obstructive sleep apnea, and gestational hypertension exhibited sympathetic hyperactivity, while individuals with gestational diabetes mellitus or preeclampsia did not. Uncomplicated pregnancies exhibited a lesser response to head‐up tilt, but an exaggerated sympathetic responsiveness to cold pressor stress compared to non‐pregnant individuals. MSNA is higher in pregnant individuals and further increased with some, but not all pregnancy complications. PROSPERO registration number: CRD42022311590.
Retracted: Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization
Authors: Hanyu Yoshihiro , Hoshino Masahiro , Usui Eisuke , Sugiyama Tomoyo , Kanaji Yoshihisa , Hada Masahiro , Nagamine Tatsuhiro , Nogami Kai , Ueno Hiroki , Sayama Kodai , Matsuda Kazuki , Sakamoto Tatsuya , Yonetsu Taishi , Sasano Tetsuo , Kakuta Tsunekazu
Published: March 2023

In the presence of functionally significant epicardial lesions, microvascular resistance reserve (MRR) calculation needs incorporation of collateral flow. Coronary fractional flow reserve (FFRcor) requiring coronary wedge pressure (Pw), which is an essential part of the true MRR calculation, is reportedly estimated by myocardial FFR (FFRmyo) not requiring Pw measurement. We sought to find an equation to calculate MRR without the need for Pw. Furthermore, we assessed changes in MRR after percutaneous coronary intervention (PCI). An equation to estimate FFRcor was developed from a cohort of 230 patients who underwent physiological measurements and PCI. Corrected MRR was calculated using this equation and compared with true MRR in 115 patients of the different set of the validation cohort. True MRR was calculated using FFRcor. FFRcor and FFRmyo showed a strong linear relationship (r2 = 0.86) and an equation was FFRcor = 1.36 × FFRmyo – 0.34. This equation provided no significant difference between corrected MRR and true MRR in the validation cohort. Pre‐PCI lower coronary flow reserve and higher index of microcirculatory resistance were independent predictors of pre‐PCI decreased true MRR. True MRR significantly decreased after PCI. In conclusion, MRR can be accurately corrected using an equation for FFRcor estimation without Pw.
Vagus nerve stimulation parameters evoke differential neuronal responses in the locus coeruleus
Authors: Farrand Ariana , Jacquemet Vincent , Verner Ryan , Owens Misty , Beaumont Eric
Published: March 2023

Vagus nerve stimulation (VNS) is used to treat drug‐resistant epilepsy and depression, with additional applications under investigation. The noradrenergic center locus coeruleus (LC) is vital for VNS effects; however, the impact of varying stimulation parameters on LC activation is poorly understood. This study characterized LC activation across VNS parameters. Extracellular activity was recorded in rats' left LC while 11 VNS paradigms, utilizing variable frequencies and bursting characteristics, were pseudorandomly delivered to the left cervical vagus for five cycles. Neurons' change from baseline firing rate and timing response profiles were assessed. The proportion of neurons categorized as responders over 5 VNS cycles doubled in comparison to the first VNS cycle (p < 0.001) for all VNS paradigms, demonstrating an amplification effect. The percentage of positively consistent/positive responders increased for standard VNS paradigms with frequencies ≥10 Hz and for bursting paradigms with shorter interburst intervals and more pulses per burst. The synchrony between pairs of LC neurons increased during bursting VNS but not standard paradigms. Also, the probability of evoking a direct response during bursting VNS was higher with longer interburst intervals and a higher number of pulses per burst. Standard paradigms between 10–30 Hz best positively activates LC with consistency to VNS while the best bursting paradigm to increase activity was 300 Hz, seven pulses per burst separated by 1 s. Bursting VNS was effective in increasing synchrony between pairs of neurons, suggesting a common network recruitment originating from vagal afferents. These results indicate differential activation of LC neurons depending on the VNS parameters delivered.
Exercise training reduces circulating cytokines in male patients with coronary artery disease and type 2 diabetes: A pilot study
Authors: Garneau Léa , Terada Tasuku , Mistura Matheus , Mulvihill Erin E. , Reed Jennifer L. , Aguer Céline
Published: March 2023

Low‐grade inflammation is central to coronary artery disease (CAD) and type 2 diabetes (T2D) and is reduced by exercise training. The objective of this study was to compare the anti‐inflammatory potential of moderate‐to‐vigorous intensity continuous training (MICT) and high‐intensity interval training (HIIT) in patients with CAD with or without T2D. The design and setting of this study is based on a secondary analysis of registered randomized clinical trial NCT02765568. Male patients with CAD were randomly assigned to either MICT or HIIT, with subgroups divided according to T2D status (non‐T2D‐HIIT n = 14 and non‐T2D‐MICT n = 13; T2D‐HIIT n = 6 and T2D‐MICT n = 5). The intervention was a 12‐week cardiovascular rehabilitation program consisting of either MICT or HIIT (twice weekly sessions) and circulating cytokines measured pre‐ and post‐training as inflammatory markers. The co‐occurrence of CAD and T2D was associated with increased plasma IL‐8 (p = 0.0331). There was an interaction between T2D and the effect of the training interventions on plasma FGF21 (p = 0.0368) and IL‐6 (p = 0.0385), which were further reduced in the T2D groups. An interaction between T2D, training modalities, and the effect of time (p = 0.0415) was detected for SPARC, with HIIT increasing circulating concentrations in the control group, while lowering them in the T2D group, and the inverse occurring with MICT. The interventions also reduced plasma FGF21 (p = 0.0030), IL‐6 (p = 0.0101), IL‐8 (p = 0.0087), IL‐10 (p < 0.0001), and IL‐18 (p = 0.0009) irrespective of training modality or T2D status. HIIT and MICT resulted in similar reductions in circulating cytokines known to be increased in the context of low‐grade inflammation in CAD patients, an effect more pronounced in patients with T2D for FGF21 and IL‐6.
Psoralea corylifolia (babchi) seeds enhance proliferation of normal human cultured melanocytes: GC–MS profiling and biological investigation
Authors: Kumar Ashok , AlGhamdi Khalid M. , Khan Anis Ahmed , Ahamad Rizwan , Ghadeer Abdulrahman , Bari Ahmed
Published: March 2023

Plants are considered as a source of medicine to treat skin-related disorders since decades. Seeds of Psoralea corylifolia were used thousands of years ago for re-pigmentation in vitiligo patients especially in South Asia. It is a well-known fact that melanocytes, which are the specialized cells in the skin causes vitiligo through a series of chemical and enzymatic reactions, mainly due to the copper containing enzyme tyrosinase. Conditions associated with overproduction of melanin are termed hyperpigmentation. The treatment options are generally limited due to the complicated and slow pathogenesis of the disease. Therefore, therapeutic repigmentation modalities for the treatment of vitiligo are highly desirable. The aim of this study was to investigate the effects of various doses of ethanol and water extracts of P. corylifolia seeds on proliferation of normal human cultured melanocytes and its gas chromatography–mass spectrometry profiling.
Differential geometric global smoothings of simple normal crossing complex surfaces with trivial canonical bundle
Authors: Doi Mamoru , Yotsutani Naoto
Published: March 2023

LetXXbe a simple normal crossing (SNC) compact complex surface with trivial canonical bundle which includes triple intersections. We prove that ifXXisdd-semistable, then there exists a family of smoothings in a differential geometric sense. This can be interpreted as a differential geometric analogue of the smoothability results due to Friedman, Kawamata-Namikawa, Felten-Filip-Ruddat, Chan-Leung-Ma, and others in algebraic geometry. The proof is based on an explicit construction of local smoothings around the singular locus ofXX, and the first author’s existence result of holomorphic volume forms on global smoothings ofXX. In particular, these volume forms are given as solutions of a nonlinear elliptic partial differential equation. As an application, we provide several examples ofdd-semistable SNC complex surfaces with trivial canonical bundle including double curves, which are smoothable to complex tori, primary Kodaira surfaces, andK3K3surfaces. We also provide several examples of such complex surfaces including triple points, which are smoothable toK3K3surfaces.
Efficient and eco-friendly isolation and purification of lignin from black liquor with choline chloride-based deep eutectic solvents
Authors: Liu Zhuang , Hou Yi , Liu Chao , Hu Songqing
Published: March 2023

This study developed an efficient and green method for isolating and purifying lignin from black liquor (BL) using deep eutectic solvents (DESs). After the short and mild process (700 W microwave-assisted, 100 °C, DES: BL 1:5 (v: v), 30 min) using optimized DES (lactic acid (LA): choline chloride (ChCl) 10:1, molar ratio), the yield and purity of lignin obtained from 100 mL BL was 1.58 g and 88.12%, respectively, which was more efficient than the results of 1.18 g and 78.54% of the conventional process. Furthermore, more than 95% of initial results were obtained after three cycles. The composition and structure of DESs and conventionally purified lignin were slightly different. The solvent costs for both processes were also evaluated, showing that the DES process has great potential to replace traditional bulky and environmentally unfriendly procedures for lignin isolation and purification and to help develop new strategies for the potential added value of lignin.
Penetration of Cultures, Penetration of Crimes: Who Do Borders Protect?
Authors: Budyn-Kulik Magdalena
Published: March 2023

The purpose of this paper is to highlight some implications of the creation of closed, culturally alien communities and the possible consequences of their functioning from a criminological and victimological perspective. Various processes emerging since about the second half of the 20th century, in Europe as well as in the United States of America, have caused cultural transformations leading to the emergence of cultural pluralism (polyculturalism, multiculturalism) in various forms. This represents one of the greatest challenges of the modern world on many levels, including prophylaxis and crime prevention. Of particular concern is the issue of assessing the behaviour of an offender belonging to a closed, culturally different group. variants of such a situation can be considered – when the perpetrator and the victim belong to culturally different communities or the same one, and depending on whether the perpetrator’s behaviour constitutes an act judged negatively in the closed group to which they belong or whether it fulfils the characteristics of a crime in the legal system of the external community.
The Polish–Belarusian Border Crisis and the (Lack of) European Union Response
Authors: Bodnar Adam , Grzelak Agnieszka
Published: March 2023

This article addresses the migration crisis on the Polish–Belarusian border. The authors believe that the actions of the Polish authorities violated the requirements set by human rights standards, including the obligations arising from Poland’s membership of the EU and the Council of Europe. This is confirmed not only by legal doctrine and the reports of non-governmental organisations, present on the ground despite all the restrictions, but also by interim-measure orders issued by the ECtHR against the Polish government. In the first part of the text, the authors summarise the situation, recalling the most important events that took place on the Polish–Belarusian border. The second part discusses the most important obligations of the EU arising both from the treaties creating it and also from the secondary legislation adopted on their basis. The juxtaposition of the EU’s actual response and the obligations written on paper may lead to the conclusion that the EU’s actions are insufficient under EU law. Relying on the texts of legal acts and other available information, the authors argue that the EU’s actions, in a certain amount of compromise with political interests, even detract from its credibility as an organisation that also aims to protect human rights externally.
The State of Emergency in Poland as the Key to Curbing Unregulated Migration
Authors: Adamczyk Anita
Published: March 2023

The purpose of this article is to analyse the Polish legislature’s activity during the state of emergency in the field of curbing illegal migration. The thesis of the article states that the introduction of the state of emergency on the Polish–Belarusian border facilitated the legal changes aimed at reducing the scale of illegal migration on the border and their implementation. The proposed changes brought about new solutions that provided, for example, for the obligation to immediately leave the territory of Poland, issuance of a decision obliging a foreigner to return when he/she crossed or attempted to cross the border illegally, or construction of a wall on the Polish–Belarusian border.
The Migration Crisis on the Polish–Belarusian Border
Authors: Zdanowicz Mieczysława
Published: March 2023

The crisis on the Polish–Belarusian border resulting in the unregulated migration of foreigners into the territory of Poland was inspired and supported by the Belarusian regime and was aimed at destabilizing the situation in the region. Poland was therefore forced to take action to protect the national border, which is also the external border of the European Union. However, some of the legal solutions that were adopted raise questions about their legality.
Criminal Prosecution and Punishment of Migrants in Spain: A Border Criminology Perspective
Authors: García-España Elisa
Published: March 2023

The exceptional use of criminal law to achieve migration policy objectives has been a reality in Spain since the first Aliens Law was passed in 1985. Since then, academia has warned about the discriminatory and exclusionary effects of this confluence. This paper critically analyses a series of exceptional Spanish criminal and migration policy measures aimed at criminalising certain population movements. The aim is to show the mechanisms used by criminal justice in Spain to manage human mobility from the perspective of border criminology. Among other things, I will analyse (1) ‘hot returns’ and (2) racial profiling in police stops, both as police reactions. I will also study (3) the expulsion of convicted foreigners and (4) criminal records as a migration control strategy and, finally, the deprivation of liberty for migration control purposes, such as (5) detention centres for migrants and (6) prison release strategies. The aim is to show that Spanish penal policy, taken in a broad sense as all eminently criminal measures and those where criminal law and immigration law converge, has as its main objective to socially render harmless (innocuousation) foreign suspects, convicts and ex-convicts in Spain with different and exceptional measures that push them to the margins of society.
Periodic nanostructures induced by point defects in Pb1-xSnxTe
Authors: Saliy Ya. , Nykyruy L. , Cempura G. , Soroka O. , Parashchuk T. , Horichok I.
Published: March 2023

Lead tin telluride solid solutions are excellent candidates for the p-type conduction legs of the thermoelectric generator modules. The investigation of their microstructure properties is an important issue, that can effectively modify their electronic and thermal transport properties. In this work, we show the experimental dependences of the Pb1-xSnxTe component distribution, which were identified as periodic nanostructures with an amplitude of λ ≈ 50-500 nm. The observed periodicity is explained by the generation and recombination of point defects due to diffusion processes during the synthesis, sintering, and annealing of samples. A model describing the formation of such inhomogeneities in Pb1-xSnxTe ternary alloys during isothermal annealing is proposed.
The Effect of synthesis methods and comparative study of structural properties of micro and nano Ferrites
Authors: Mathad Shridhar N. , Pathan A. T. , Shaikh A. M. , Sushant S.K.
Published: March 2023

In this study, Mn(x)Zn(1-x)Fe2O4 ferrite samples with x=0.4 and 0.6 were synthesized using a solid-state  method and co-precipitation method. In order to determine the effects of various concentrations (x) on the ferrite's structure, particle size, and crystalline phases, prepared samples were analysed using X-ray diffraction (XRD). The XRD patterns revealed that the synthesized samples display a single-phase cubic spinel structure.FTIR analysis showed for both synthesis method have absorption band in the range 400 to 1000 cm-1.SEM analysis shows extreme homogeneity of all the samples. EDX analysis was used to examine for Mn0.4Zn0.6Fe204,The prepared ferrites powders contain Mn, Zn, and Fe, as shown in both synthesis methods.In this approach, alternative synthesis routes for these ferrites are suggested in this study in order to get around some limitations of the traditional preparation method.
Peculiarities of structural, electrokinetic, energetic, and magnetic properties semiconductive solid solution Lu1-xVxNiSb
Authors: Stadnyk Yu. , Romaka V.A. , Romaka L. , Demchenko P. , Horyn A. , Poplavskyi O. , Pashkevych V. , Haraniuk P.
Published: March 2023

The structural, electrokinetic, energetic, and magnetic properties of the new semiconductive solid solution Lu1-xVxNiSb, х=0–0.10, were studied. It was shown that V atoms could simultaneously occupy different crystallographic positions in different ratios, generating structural defects of acceptor and donor nature. This creates corresponding acceptor and donor bands in the bandgap εg of Lu1-xVxNiSb. The mechanism of the formation of two acceptor bands with different depths of occurrence has been established: a small acceptor band εА2, formed by defects due to the substitution of Ni atoms by V ones in the 4c position, and band εА1, generated by vacancies in the LuNiSb structure. The ratio of the concentrations of generated defects determines the position of the Fermi level εF and the conduction mechanisms. The investigated solid solution Lu1-xVxNiSb is a promising thermoelectric material.
Edición independiente: identidad(es) en el campo editorial mexicano contemporáneo
Authors: Hurtado Alejandra
Published: March 2023

En este trabajo se estudian las problemáticas en torno a lo “independiente” como categoría de identidad del campo editorial mexicano contemporáneo, con el objetivo de proponer un abordaje teórico que remita a otras posibilidades de análisis sobre la multiplicidad de proyectos que se reconocen bajo este término. En el siglo XXI, en el marco de una alta concentración editorial, se han creado iniciativas colectivas como la Alianza de Editoriales Mexicanas Independiente, la Liga de Editoriales Independientes y la Feria del Libro Independiente, entre otras, y más de cien proyectos editoriales asociados a este término, aunque son agentes heterogéneos que no operan necesariamente bajo un común denominador. A partir de la teoría de la identidad de Stuart Hall en diálogo con Ernesto Laclau y Jaques Derrida, aquí se analiza la edición “independiente” como categoría que debe leerse bajo borradura, pues está basada en una paradoja: por un lado, opera efectivamente al identificar a diversos agentes como colectividad cuyas prácticas abanderan la “independencia” y, por otro, es un casillero vacío desde donde se enuncian múltiples proyectos cuyos posicionamientos políticos y estéticos están por ser explorados, para llegar a una comprensión más amplia del campo editorial actual.
Parteras tradicionales afrodescendientes del Pacífico colombiano y su aporte a la construcción de paz
Authors: Angola Maryuri
Published: March 2023

El presente artículo de investigación analiza el aporte  de las parteras tradicionales afrodescendientes del Pacifico colombiano, a la construcción de paz en sus comunidades. Para realizar este análisis se empleó un acercamiento cualitativo a través de la técnica de entrevista semiestructurada a parteras y parturientas oriundas del Pacifico colombiano, residentes en Cali, además de observación participante en reuniones organizativas de mujeres parteras pertenecientes a la Asociación de Parteras Unidas del Pacifico, ASOPARUPA, y revisión Bibliográfica. Se evidencia como resultado que las prácticas cotidianas de las parteras tradicionales afrodescendientes del Pacifico colombiano generan un tipo de autonomía, agencia, reflexión social y transformación endógena, que permite atribuir capacidades para la cohesión comunitaria, la defensa de la vida y la diversidad cultural, lo cual se traduce en prácticas que fortalecen la construcción de paz y por ende aportan a la búsqueda de la justicia social en Colombia.
La religiosidad patológica de la sociedad del espectáculo: reflexiones sobre el pensamiento de Guy Debord
Authors: Solís Nova David , Molteni Agostino
Published: March 2023

Guy Debord califica la forma de vida creada por la economía mercantil como una sociedad del espectáculo. Poco a poco, según el pensador francés, la mercancía ha ido transformándose en un fetiche espectacular logrando imponer una imagen pre-fabricada por sobre la experiencia directa con el mundo y los otros sujetos. Esto último causa, inevitablemente, una sociedad de consumidores pasivos, en cuanto meros contempladores de ideas ya hechas. En base a lo anterior, Debord concluye que la sociedad del espectáculo no es más que la concreción material y técnica de lo que él considera la ilusión religiosa. La modernidad que le ha tocado observar no sería, en absoluto, una época secularizada, sino, muy por el contrario, agudamente religiosa. Para superar el pensamiento contemplativo-religioso del espectáculo, Debord pone sus esperanzas y sus esfuerzos de análisis en los ‘consejos obreros’, una especial forma de pensamiento compuesto en los que podría encontrarse el método filosófico propiamente debordiano. Todo esto nos permitirá generar algunas reflexiones sobre su diagnóstico y prolongar su pensamiento en torno a las soluciones que ofrece para una salida de la dominante sociedad del espectáculo aún presente en nuestros días.
Effect of some characteristics of fathers on paternal-infant attachment in the postpartum period
Authors:   Freelance Nurse, Güzeloba, Antalya, Turkey, Kaba Gülsüm , Arguvanli Çoban Sibel ,   Psychiatric Nursing Department, Faculty of Health Science, Zonguldak Bulent Ecevit University, Esenköy/Kozlu, Zonguldak, Turkey
Published: March 2023

Introduction and aim. The paternal attachment can affect the academic, social and emotional development of the child in the future. The study was conducted in a descriptive-cross-sectional design to determine the impacts of some characteristics of fathers on paternal attachment. Material and method. The study was conducted with 278 fathers who had 3-12 months old infants. The data were collected by using the “Father Information Form” and the “Postnatal Paternal-Infant Attachment Questionnaire (PPAQ)”. Results. It was found in the present that the mean PPAQ score of the fathers who were exposed to domestic violence in their childhood was significantly lower than those who were not (p=0.001). The mean PPAQ score of the fathers whose infant was born by cesarean section (p=0.017) and who had physical contact for the first 24 hours (p=0.047) was found to be significantly higher. The mean PPAQ score was significantly higher in fathers who had a physical contact duration of 7 hours or more than those with less physical contact durations (p=0.030). Conclusion. In this study, some characteristics of fathers were found to affect father-infant attachment. It may be recommended to plan preventive interventions for risky fathers.