bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial variation of amount effect over peninsular India and Sri Lanka: Role of seasonality
Authors: Lekshmy P. R. , Midhun M. , Ramesh R.
Published: June 2015

The relationship between rain amount and rain δ18O of monsoon rain (amount effect) helps to reconstruct past monsoon variability from proxies (e.g., tree rings and speleothems). Analysis of new (and published) data of the δ18O of monsoon rains and vapor at nine stations shows that in regions of distinct seasonality in precipitation (e.g., peninsular India), the noise in such reconstructions can be minimized by a careful selection of sites. Peninsular India receives rain from both the Indian summer monsoon (ISM) and the northeast monsoon (NEM). Significant amount effect is observed only where the NEM rainfall is larger than or comparable to ISM rainfall. This is due to the higher quantity of NEM rain with more depleted 18O relative to ISM rain. NEM rain is more depleted in 18O because of cyclonic activity over Bay of Bengal, and the 18O depletion of Bay of Bengal surface waters due to post‐ISM river runoff.
Core/Shell Iron/Oxide Nanoparticles for Improving the Magneto‐Dielectric Properties of Polymer Composites
Authors: Yang Ta‐I , Chuang Chun‐Yu , Yang Shu‐Chian , Kempel Leo C. , Kofinas Peter
Published: June 2015

A simple method to obtain high magnetic permeability (μr), high dielectric permittivity (ϵr), and low loss polymer composites with core/shell iron/metal oxide particles is developed. Magnetic iron (Fe0) particles with protective SiO2 shells are synthesized in aqueous environment at room temperature. The shells provide electrical insulting layers which decrease energy loss and also prevent the possibility of μr decrease due to Fe0 oxidation. Furthermore, Fe0 particles could also be coated with TiO2 shells which allow ϵr to be tuned. The ϵr and μr of the resulting polydimethylsiloxane composites are optimized for core‐shell particle doping. The value of ϵr is up to 9.8 and most importantly, the μ is close to 2 at 1 GHz with 43 wt% doping of core‐shell particles. The dielectric loss of the composites is less than 0.02.
Roll‐to‐Roll Printed Silver Nanowire Semitransparent Electrodes for Fully Ambient Solution‐Processed Tandem Polymer Solar Cells
Authors: Angmo Dechan , Andersen Thomas R. , Bentzen Janet J. , Helgesen Martin , Søndergaard Roar R. , Jørgensen Mikkel , Carlé Jon E. , Bundgaard Eva , Krebs Frederik C.
Published: June 2015

Silver nanowires (AgNWs) and zinc oxide (ZnO) are deposited on flexible substrates using fast roll‐to‐roll (R2R) processing. The AgNW film on polyethylene terephthalate (PET) shows >80% uniform optical transmission in the range of 550–900 nm. This electrode is compared to the previously reported and currently widely produced indium‐tin‐oxide (ITO) replacement comprising polyethylene terephthalate (PET)|silver grid|poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)|ZnO known as Flextrode. The AgNW/ZnO electrode shows higher transmission than Flextrode above 490 nm in the electromagnetic spectrum reaching up to 40% increased transmission at 750 nm in comparison to Flextrode. The functionality of AgNW electrodes is demonstrated in single and tandem polymer solar cells and compared with parallel devices on traditional Flextrode. All layers, apart from the semitransparent electrodes which are large‐scale R2R produced, are fabricated in ambient conditions on a laboratory roll‐coater using printing and coating methods which are directly transferrable to large‐scale R2R processing upon availability of materials. In a single cell structure, Flextrode is preferable with active layers based on poly‐3‐hexylthiophene(P3HT):phenyl‐C61‐butyric acid methylester (PCBM) and donor polymers of similar absorption characteristics while AgNW/ZnO electrodes are more compatible with low band gap polymer‐based single cells. In tandem devices, AgNW/ZnO is more preferable resulting in up to 80% improvement in PCE compared to parallel devices on Flextrode.
Bioactive Photodegradable Hydrogel for Cultivation and Retrieval of Embryonic Stem Cells
Authors: You Jungmok , Haque Amranul , Shin Dong‐Sik , Son Kyung Jin , Siltanen Christian , Revzin Alexander
Published: June 2015

The development of a novel photodegradable heparin‐based hydrogel for cultivation and retrieval of embryonic stem cells is described. Mouse embryonic stem cells cultured atop the gel with encapsulated growth factors (GFs) express higher levels of differentiation markers compared to a standard protocol employing soluble GFs. Beyond improving differentiation of stem cells, the novel hydrogels can be used to release specific stem cell colonies without disturbing neighboring cells. This way, stem cell colonies can be retrieved at different time points and from different locations of the culture surface for polymerase chain reaction (PCR) analysis without the loss of the microenvironment context. The ability to retrieve some stem cell colonies without disturbing neighboring colonies will open possibilities for characterizing in‐dish heterogeneity of stem cell phenotype and will also allow to conserve cells/reagents. Overall, the bioactive photodegradable hydrogel developed in this study may offer new possibilities for cultivation and analysis of stem cells as well as other cell types.
Fabrication of a Large‐Area Hierarchical Structure Array by Combining Replica Molding and Atmospheric Pressure Plasma Etching
Authors: Lee Bong Kuk , Baek In‐Bok , Lee Byeong‐Jun , Kim Yarkyeon , Jang Won Ick , Yoon Yong Sun , Yu Han Young
Published: June 2015

A novel approach to produce a large‐area hierarchical structure array is presented. The method combines replica molding and atmospheric pressure plasma (APP) etching processes. Liquid blends consisting of siliconized silsesquioxane acrylate (Si‐SSQA), polyethylene glycol dimethacrylate (PEGDMA), and photoinitiator are used as roughness formable materials during APP etching. Microstructures composed of the Si‐SSQA/PEGDMA mixtures are fabricated by replica molding. Nanoroughness is realized on the microstructures by argon/oxygen (Ar/O2) APP etching in air. The nano­roughness on molded microstructures is efficiently controlled by varying the weight ratio of Si‐SSQA to PEGDMA and the etching time. The hierarchical structures fabricated by combining replica molding and Ar/O2 APP etching show superhydrophilicity with a long‐term stability, resulting in the formation of hydroxyl‐terminated silicon oxide layer with the reorientation limit. On the other hand, the hierarchical structures treated with a perfluorinated self‐assembled monolayer (SAM) show increased the water contact angles of up to 161° depending on the morphology of the hierarchical structures. The increment of water contact angles is consistent with increment of the nano‐/microroughness of hierarchical structures.
DDQ‐mediated Direct C(sp3)H Cyanation of Benzyl Ethers and 1,3‐Diarylpropenes under Solvent‐ and Metal‐free Conditions
Authors: Kong Shanshan , Zhang Lingqiong , Dai Xiaoli , Tao Lianzhi , Xie Chunsong , Shi Lei , Wang Min
Published: June 2015

A direct cyanation of benzyl ethers and 1,3‐diarylpropenes with TMSCN was performed under solvent‐ and metal‐free conditions. This oxidative cross dehydrative coupling (CDC) reaction was promoted by 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) and provided rapid access to a broad range of nitriles in good to excellent yields.

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Systematic design of an extractive distillation for maximum‐boiling azeotropes with heavy entrainers
Authors: Shen Weifeng , Dong Lichun , Wei Shun'an , Li Jie , Benyounes Hassiba , You Xinqiang , Gerbaud Vincent
Published: June 2015

Extractive distillation is one of the most attractive approaches for separating azeotropic mixtures. Few contributions have been reported to design an extractive distillation for separating maximum‐boiling azeotropes and no systematic approaches for entrainer screening have been presented. A systematic approach to design of two‐column extractive distillation for separating azeotropes with heavy entrainers has been proposed. A thermodynamic feasibility analysis for azeotropes with potential heavy entrainers was first conducted. Then, five important properties are selected for entrainer evaluation. Fuzzy logic and develop membership functions to calculate attribute values of selected properties have been used. An overall indicator for entrainer evaluation is proposed and a ranking list is generated. Finally, the top five entrainers from the ranking list have been selected and use process optimization techniques to further evaluate selected entrainers and generate an optimal design. The capability of the proposed method is illustrated using the separation of acetone–chloroform azeotropes with five potential entrainers. © 2015 American Institute of Chemical Engineers AIChE J, 61: 3898–3910, 2015
Complications of non‐occlusive mesenteric ischaemia
Authors: Weledji Elroy Patrick
Published: June 2015

Case

A 65‐year‐old arteriopath with a history of myocardial infarction 5 months previously presented with classical signs of mesenteric infarction that led to a right hemicolectomy with an end ileostomy.

Outcome

Postoperative complications occurred due to unusually large volume ileostomy output in the subsequent 4 weeks, resulting in severe volume depletion and the sequelae that required intensive care support. These were triggered and prolonged by two episodes of intra‐abdominal sepsis.

Conclusions

Sepsis‐induced high ileostomy output following intestinal resection for non‐occlusive mesenteric ischaemia is a serious complication. Early restoration of intestinal continuity following bowel resection for established infarction may prevent this complication.
Region‐Selective Deposition of Core–Shell Nanoparticles for 3 D Hierarchical Assemblies by the Huisgen 1,3‐Dipolar Cycloaddition
Authors: Etschel Sebastian H. , Portilla Luis , Kirschner Johannes , Drost Martin , Tu Fan , Marbach Hubertus , Tykwinski Rik R. , Halik Marcus
Published: June 2015

A method for the region‐selective deposition of nanoparticles (NPs) by the Huisgen 1,3‐dipolar cycloaddition is presented. The approach enables defined stacking of various oxide NPs in any order with control over layer thickness. Thereby the reaction is performed between a substrate, functionalized with a self‐assembled monolayer of an azide‐bearing phosphonic acid (PA) and aluminum oxide (AlOx) NPs functionalized with an alkyne bearing PA. The layer of alkyne functionalized AlOx NPs is then used as substrate for the deposition of azide‐functionalized indium tin oxide (ITO) NPs to provide a binary stack. This progression is then conducted with alkyne‐functionalized CeO2 NPs, yielding a ternary stack of NPs with three different NP cores. The stacks are characterized by AFM and SEM, defining the region‐selectivity of the deposition technique. Finally, these assemblies have been tested in devices as a dielectric to form a capacitor resulting in a dramatic increase in the measured capacitance.
A Family of High‐Efficiency Hydrogen‐Generation Catalysts Based on Ammonium Species
Authors: Lu Lilin , Zhang Haijun , Zhang Shaowei , Li Faliang
Published: June 2015

Development of highly active, low cost, ecologically friendly, and durable homogenous catalysts for hydrogen generation from hydrolysis of borohydride is one of the most desirable pathways for future hydrogen utilization. The unexpected catalytic activities of inorganic ammonium species and the corresponding mechanisms underpinning them are studied. The catalytic activities of the ammonium species are higher than or comparable to those of mostly investigated noble‐metal/transition‐metal catalysts (such as Pd, Pt, Ni, and Co) but are considerably cheaper, more environmentally friendly, and more readily available. Quantum chemical calculations indicate that the unique ammonium‐induced reaction pathway involved with a barrierless elementary reaction at the reaction entrance and the formation of the highly active intermediate BH3 are responsible for the unexpected catalytic activities and the significantly accelerated hydrogen generation.
Actinide‐Mediated Catalytic Addition of EH Bonds (E=N, P, S) to Carbodiimides, Isocyanates, and Isothiocyanates
Authors: Karmel Isabell S. R. , Tamm Matthias , Eisen Moris S.
Published: June 2015

Unprecedented catalytic reactivity of actinide coordination complexes toward heterocumulenes, such as carbodiimides, isocyanates, and isothiocyanates is reported. The mono(imidazolin‐2‐iminato) thorium(IV) complex [Th(ImDippN){N(SiMe3)2}3] (1) was applied as a precatalyst for the addition of EH (E=N, P, S) bonds to the YCX core (Y=R2N; X=NR2, O, S) of carbodiimides, isocyanates, and isothiocyanates. The respective insertion products were obtained in high yields under mild reaction conditions, with complex 1 displaying high tolerance toward functional groups and heteroatoms.
Cartilage‐Specific Near‐Infrared Fluorophores for Biomedical Imaging
Authors: Hyun Hoon , Owens Eric A. , Wada Hideyuki , Levitz Andrew , Park GwangLi , Park Min Ho , Frangioni John V. , Henary Maged , Choi Hak Soo
Published: June 2015

A novel class of near‐infrared fluorescent contrast agents was developed. These agents target cartilage with high specificity and this property is inherent to the chemical structure of the fluorophore. After a single low‐dose intravenous injection and a clearance time of approximately 4 h, these agents bind to all three major types of cartilage (hyaline, elastic, and fibrocartilage) and perform equally well across species. Analysis of the chemical structure similarities revealed a potential pharmacophore for cartilage targeting. Our results lay the foundation for future improvements in tissue engineering, joint surgery, and cartilage‐specific drug development.
High‐Conductivity Two‐Dimensional Polyaniline Nanosheets Developed on Ice Surfaces
Authors: Choi Il Young , Lee Joungphil , Ahn Hyungmin , Lee Jinho , Choi Hee Cheul , Park Moon Jeong
Published: June 2015

A new method to develop two‐dimensional PANI nanosheets using ice as a removable hard template is presented. Distinctly high current flows of 5.5 mA at 1 V and a high electrical conductivity of 35 S cm−1 were obtained for the polyaniline (PANI) nanosheets, which marked a significant improvement from previously values on other PANIs reported over the past decades. These improved electrical properties of ice‐templated PANI nanosheets were attributed to the long‐range ordered edge‐on π‐stacking of the quinoid ring, ascribed to the ice surface‐assisted vertical growth of PANI. The unprecedented advantages of the ice‐templated PANI nanosheets are two‐fold. First, the PANI nanosheet can be easily transferred onto various types of substrates via float‐off from the ice surfaces. Second, PANI can be patterned into any shape using predetermined masks, and this is expected to facilitate the eventual convenient and inexpensive application of conducting polymers in versatile electronic device forms.
Copper‐Catalyzed Trifluoromethylazidation of Alkynes: Efficient Access to CF3‐Substituted Azirines and Aziridines
Authors: Wang Fei , Zhu Na , Chen Pinhong , Ye Jinxing , Liu Guosheng
Published: June 2015

A novel method for convenient access to CF3‐containing azirines has been developed, and involves a copper‐catalyzed trifluoromethylazidation of alkynes and a photocatalyzed rearrangement. Both terminal and internal alkynes are compatible with the mild reaction conditions, thus delivering the CF3‐containing azirines in moderate to good yields. The azirines can be converted into various CF3‐substituted aziridines.
The Retro‐Hydroformylation Reaction
Authors: Kusumoto Shuhei , Tatsuki Toshiumi , Nozaki Kyoko
Published: June 2015

Hydroformylation, a reaction that adds carbon monoxide and dihydrogen across an unsaturated carbon–carbon multiple bond, has been widely employed in the chemical industry since its discovery in 1938. In contrast, the reverse reaction, retro‐hydroformylation, has seldom been studied. The retro‐hydroformylation reaction of an aldehyde into an alkene and synthesis gas (a mixture of carbon monoxide and dihydrogen) in the presence of a cyclopentadienyl iridium catalyst is now reported. Aliphatic aldehydes were converted into the corresponding alkenes in up to 91 % yield with concomitant release of carbon monoxide and dihydrogen. Mechanistic control experiments indicated that the reaction proceeds by retro‐hydroformylation and not by a sequential decarbonylation–dehydrogenation or dehydrogenation–decarbonylation process.
Electron‐Deficient Tetrabenzo‐Fused Pyracylene and Conversions into Curved and Planar π‐Systems Having Distinct Emission Behaviors
Authors: Chaolumen  , Murata Michihisa , Sugano Yasunori , Wakamiya Atsushi , Murata Yasujiro
Published: June 2015

Polycyclic aromatic compounds containing fully unsaturated five‐membered ring(s) have been intensively studied because of their unique properties, which include high electron affinity and reactivity. Reported herein is an efficient route for the synthesis of tetrabenzo‐fused pyracylene, which comprises pyracylene and tetracene segments, using intramolecular oxidative CH coupling. It was shown to possess high electron affinity and was found to undergo addition reactions with n‐butyllithium or benzyne. These reactions led to either a 1,4‐addition compound or triptycene‐type adduct with a curved or planar π‐system, respectively. Although these compounds exhibited similar sky‐blue emissions in a dilute solution, the emission band of the 1,4‐addition compound was significantly red‐shifted in the solid state and exhibited intense yellow emission attributable to the excimer, while the triptycene‐type adduct retained the intense blue color emission in the solid state.
Highly Efficient, Convergent, and Enantioselective Synthesis of Phthioceranic Acid
Authors: Xu Shiqing , Oda Akimichi , Bobinski Thomas , Li Haijun , Matsueda Yohei , Negishi Ei‐ichi
Published: June 2015

A new strategy for highly concise, convergent, and enantioselective access to polydeoxypropionates has been developed. ZACA‐Pd‐catalyzed vinylation was used to prepare smaller deoxypropionate fragments, and then two key sequential Cu‐catalyzed stereocontrolled sp3–sp3 cross‐coupling reactions allowed convergent assembly of smaller building blocks to build‐up long polydeoxypropionate chains with excellent stereoselectivity. We employed this strategy for the synthesis of phthioceranic acid, a key constituent of the cell‐wall lipid of Mycobacterium tuberculosis, in just 8 longest linear steps with full stereocontrol.
Synthesis and characterization of polyphenylaminophosphazene and fluorinated polyarylaminophosphazene
Authors: Zhou Lisheng , Zhang Guangcheng , Li Jianwei , Zhao Long , Zhang Xinyu , Wei Xuan
Published: June 2015

Two polyarylaminophosphazenes, poly[bis(phenylamino)phosphazene] (PBAP) and poly[bis(p‐trifluoroethoxyphenylamino)phosphazene] (PBTAP), were successfully synthesized by ring‐opening polymerizations and nucleophilic substitution reactions. Their chemical structures, thermal properties, and surface properties were investigated by NMR, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and water contact angles (WCA). The results indicate that the glass‐transition temperature (Tg), thermal stability, and WCAs of PBAP and PBTAP presented obviously differences; this suggested that PBTAP possessed the lower Tg and higher contact angle than PBAP. This was attributed to the influence of trifluoroethoxy at the para position of aniline. TGA measurements indicated that PBAP possessed a higher thermal stability than PBTAP; this was attributed to the strong electron‐withdrawing influence of the trifluoroethoxy. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42542.
Resorcinol formaldehyde xerogels modified with mercapto functional groups as mercury adsorbent
Authors: Motahari Siamak , Heidari Behzad Shiroud , Motlagh Ghodratollah Hashemi
Published: June 2015

Resorcinol formaldehyde xerogels are modified by mercaptopropyl‐trimethoxysilane during the sol–gel process used to produce the xerogel. The chemical modification is confirmed by Fourier‐transform infrared spectroscopy. The xerogel is then used to adsorb mercury ions from aqueous solutions. The effects of the molar ratios of the precursors as well as the catalyst and the modifier are studied on the textural properties of the xerogel and the adsorption efficiency. It is shown that the chemical modification of the resorcinol formaldehyde xerogels creates the chemical sites on the structure of the xerogel to adsorb more mercury ions and increase the adsorption efficiency. At the same time, chemical modification decreases the xerogel surface area which results in a reduction of the mercury adsorption. Therefore, there exists an optimum value for the chemical modification of the xerogel to achieve the highest adsorption efficiency. Adsorption kinetics as well as equilibrium isotherm of xerogels were examined using pseudo‐first‐ and second‐order kinetic equations, and Freundlich and Langmuir isotherm models. The adsorption kinetics was found to follow the pseudo‐second‐order kinetic equations. The experimental data was also fitted into the Longmuir model more precisely comparing the Freundlich model. Finally, a series of mercury adsorption–desorption tests proved that the optimized mercapto‐modified resorcinol formaldehyde xerogel was an efficient reusable adsorbent for mercury ions. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42543.
Multidisciplinary therapy for granulocyte‐colony‐stimulating factor producing carcinosarcoma of the esophagus: report of a case
Authors: Kobayashi Shinichiro , Nagata Yasuhiro , Tokai Hirotaka , Ito Masahiro , Fujioka Hikaru
Published: June 2015

Key Clinical Message

The granulocyte‐colony‐stimulating factor (G‐CSF)‐producing esophageal carcinosarcoma is extremely rare in esophageal cancer. In the present case, multidisciplinary therapy, which is surgical resection with preoperative chemotherapy, has been effectively treatment to granulocyte‐colony‐stimulating factor producing esophageal carcinosarcoma of the esophagus.
Energy Efficiency of Alkaline Direct Ethanol Fuel Cells Employing Nanostructured Palladium Electrocatalysts
Authors: Wang Lianqin , Lavacchi Alessandro , Bevilacqua Manuela , Bellini Marco , Fornasiero Paolo , Filippi Jonathan , Innocenti Massimo , Marchionni Andrea , Miller Hamish Andrew , Vizza Francesco
Published: June 2015

Carbon supported nanostructured palladium or palladium alloys are considered the best performing anode electrocatalysts currently employed in alkaline electrolyte membrane direct ethanol fuel cells (AEM‐DEFCs). High initial peak power densities are generally obtained as Pd preferentially favors the selective oxidation of ethanol forming acetate thus avoiding strongly poisoning intermediates such as CO. However, few studies exist that investigate DEFC performance in terms of both energy efficiency and discharge energy density, as well as power density depending on the concentration of fuel. In this paper we have determined such parameters for room temperature air breathing AEM‐DEFCs equipped with Pd based anodes, anion exchange membranes and FeCo/C cathode electrocatalysts. Combined with the optimization of the fuel composition a maximum energy efficiency of ≈7 % was obtained for this AEM‐DEFC. Such a performance suggests that devices of this type are suitable for supplying low power applications such as small portable electronic devices.
Organocatalytic Enantioselective Aza‐Michael Reaction of Benzotriazole to β,β‐Disubstituted Nitroalkenes
Authors: Chen Sheng‐Wei , Zhang Gui‐Cheng , Lou Qin‐Xin , Cui Wei , Zhang Sha‐Sha , Hu Wen‐Hui , Zhao Jun‐Ling
Published: June 2015

An enantioselective aza‐Michael reaction of benzotriazole to β,β‐disubstituted nitroalkenes has been developed. This reaction was catalyzed efficiently by a bifunctional thiourea catalyst, affording the corresponding products, bearing quaternary stereogenic centers, in moderate to high yields (up to 80 %) and with high enantioselectivities of up to 95 % ee.
n‐Dopants Based on Dimers of Benzimidazoline Radicals: Structures and Mechanism of Redox Reactions
Authors: Zhang Siyuan , Naab Benjamin D. , Jucov Evgheni V. , Parkin Sean , Evans Eric G. B. , Millhauser Glenn L. , Timofeeva Tatiana V. , Risko Chad , Brédas Jean‐Luc , Bao Zhenan , Barlow Stephen , Marder Seth R.
Published: June 2015

Dimers of 2‐substituted N,N′‐dimethylbenzimidazoline radicals, (2‐Y‐DMBI)2 (Y=cyclohexyl (Cyc), ferrocenyl (Fc), ruthenocenyl (Rc)), have recently been reported as n‐dopants for organic semiconductors. Here their structural and energetic characteristics are reported, along with the mechanisms by which they react with acceptors, A (PCBM, TIPS‐pentacene), in solution. X‐ray data and DFT calculations both indicate a longer CC bond for (2‐Cyc‐DMBI)2 than (2‐Fc‐DMBI)2, yet DFT and ESR data show that the latter dissociates more readily due to stabilization of the radical by Fc. Depending on the energetics of dimer (D2) dissociation and of D2‐to‐A electron transfer, D2 reacts with A to form D+ and A− by either of two mechanisms, differing in whether the first step is endergonic dissociation or endergonic electron transfer. However, the D+/0.5 D2 redox potentials—the effective reducing strengths of the dimers—vary little within the series (ca. −1.9 V vs. FeCp2+/0) (Cp=cyclopentadienyl) due to cancelation of trends in the D+/0 potential and D2 dissociation energy. The implications of these findings for use of these dimers as n‐dopants, and for future dopant design, are discussed.
Chemoenzymatic Syntheses of Sialylated Oligosaccharides Containing C5‐Modified Neuraminic Acids for Dual Inhibition of Hemagglutinins and Neuraminidases
Authors: Birikaki Lémonia , Pradeau Stéphanie , Armand Sylvie , Priem Bernard , Márquez‐Domínguez Luis , Reyes‐Leyva Julio , Santos‐López Gerardo , Samain Eric , Driguez Hugues , Fort Sébastien
Published: June 2015

A fast chemoenzymatic synthesis of sialylated oligosaccharides containing C5‐modified neuraminic acids is reported. Analogues of GM3 and GM2 ganglioside saccharidic portions where the acetyl group of NeuNAc has been replaced by a phenylacetyl (PhAc) or a propanoyl (Prop) moiety have been efficiently prepared with metabolically engineered E. coli bacteria. GM3 analogues were either obtained by chemoselective modification of biosynthetic N‐acetyl‐sialyllactoside (GM3NAc) or by direct bacterial synthesis using C5‐modified neuraminic acid precursors. The latter strategy proved to be very versatile as it led to an efficient synthesis of GM2 analogues. These glycomimetics were assessed against hemagglutinins and sialidases. In particular, the GM3NPhAc displayed a binding affinity for Maackia amurensis agglutinin (MAA) similar to that of GM3NAc, while being resistant to hydrolysis by Vibrio cholerae (VC) neuraminidase. A preliminary study with influenza viruses also confirmed a selective inhibition of N1 neuraminidase by GM3NPhAc, suggesting potential developments for the detection of flu viruses and for fighting them.
Chiral Bis(imidazolidine)‐Derived NCN Pincer Rh Complex for Catalytic Asymmetric Mannich Reaction of Malononitrile with N‐Boc Imines
Authors: Arai Takayoshi , Moribatake Takuma , Masu Hyuma
Published: June 2015

Chiral bis(imidazolidine)‐derived NCN–rhodium complexes ([PhBidine‐RhX2] and [tBu‐PhBidine‐RhX2]) were prepared by a CH insertion method, and the structures were unequivocally determined by X‐ray crystallographic analysis. The [tBu‐PhBidine‐Rh(OAc)2] complex smoothly catalyzed an asymmetric Mannich reaction of malononitrile with N‐Boc imines to give products in up to 94 % ee, which are useful for the synthesis of chiral α‐amino acids.
ChemInform Abstract: Ternary Aurides RE4Mg3Au10 (RE: Y, Nd, Sm, Gd—Dy) and Their Silver Analogues.
Authors: Block Theresa , Johnscher Michael , Linsinger Stefan , Rodewald Ute Ch. , Poettgen Rainer
Published: June 2015

The title compounds are prepared by induction melting of the elements in sealed Nb tubes (rapidly heating to about 1500 K, 1300 K for 30 min, and 900 K for 2 h).
ChemInform Abstract: The Equiatomic Intermetallics REPtCd (RE: La, Ce, Pr, Nd, Eu) and Magnetic Properties of CeAuCd.
Authors: Johnscher Michael , Tappe Frank , Niehaus Oliver , Poettgen Rainer
Published: June 2015

The title compounds are prepared by induction‐melting of the elements in sealed Nb ampules (1323 K for 3 h and 773 K for 4 d) and characterized by powder XRD.
ChemInform Abstract: Structural and Magnetic Properties of RTiNO2 (R: Ce, Pr, Nd) Perovskite Nitride Oxides.
Authors: Porter Spencer H. , Huang Zhenguo , Cheng Zhenxiang , Avdeev Maxim , Chen Zhixin , Dou Shixue , Woodward Patrick M.
Published: June 2015

LnTiNO2 (Ln: Ce, Pr, Nd) phases are prepared by solid state ammonolysis of Ln2Ti2O7 precursors by repeated gaseous NH3 treatment during annealing (950 °C, 20 h).
ChemInform Abstract: The Crystal Structure of Sc5Co2In4.
Authors: Tyvanchuk Yuriy , Gulay Nataliya , Bigun Inna , Galadzhun Yaroslav , Kalychak Yaroslav
Published: June 2015

The new title compound is prepared by arc melting of the pure elements (annealing at 870 K for 2 months, yield given in g).
ChemInform Abstract: Quinine‐Derived Thiourea and Squaramide Catalyzed Conjugate Addition of α‐Nitrophosphonates to Enones: Asymmetric Synthesis of Quaternary α‐Aminophosphonates.
Authors: Bera Kalisankar , Namboothiri Irishi N. N.
Published: June 2015

Quinine based thioureas and squaramides are investigated as catalysts for the asymmetric addition of nitrophosphonates to enones.
ChemInform Abstract: Organocatalytic Enantioselective Formal C(sp2)—H Alkylation.
Authors: Manna Madhu Sudan , Mukherjee Santanu
Published: June 2015

The alkylative desymmetrization of prochiral 2,2‐disubstituted cyclopentene‐1,3‐diones with nitroalkanes using a quinine‐derived chiral catalyst is described.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of 1,1‐Diarylethanes by Transfer Hydrogenation.
Authors: Wang Zhaobin , Ai Fujin , Wang Zheng , Zhao Wanxiang , Zhu Guangyu , Lin Zhenyang , Sun Jianwei
Published: June 2015

A new organocatalytic transfer hydrogenation strategy for the efficient asymmetric synthesis of 1,1‐diarylethanes is given.
ChemInform Abstract: Hydrogenation of Unactivated Enamines to Tertiary Amines: Rhodium Complexes of Fluorinated Phosphines Give Marked Improvements in Catalytic Activity.
Authors: Tin Sergey , Fanjul Tamara , Clarke Matthew L
Published: June 2015

This method uses low catalyst loadings and is suitable for the hydrogenation of tetrasubstituted enamines.
ChemInform Abstract: Rhodium‐Catalyzed Direct C—H Allylation of N‐Sulfonyl Ketimines with Allyl Carbonates.
Authors: Mei Shu‐Tao , Wang Nan‐Jin , Ouyang Qin , Wei Ye
Published: June 2015

An efficient procedure is elaborated for the direct C—H allylation of imines (I) and different cyclic ketimines.
ChemInform Abstract: Copper(I) Iodide Catalyzed Synthesis of Primary Propargylic Alcohols from Terminal Alkyne.
Authors: Kundu Shrishnu Kumar , Mitra Kanchan , Majee Adinath
Published: June 2015

The title compounds (II) are highly efficient obtained by reaction of a variety of terminal alkynes with paraformaldehyde under mild reaction condition.
ChemInform Abstract: Synthesis of α,α‐Difluoro‐β‐amino Carbonyl‐Containing Sulfonamides and Related Compounds.
Authors: Xie Chen , Wu Lingmin , Zhou Jie , Mei Haibo , Soloshonok Vadim A. , Han Jianlin , Pan Yi
Published: June 2015

Mannich addition reactions between in situ generated α,α‐difluoroenolates and various N‐sulfonyl imines readily occur with exceptionally high reaction rates at ambient temperature.
ChemInform Abstract: Chiral Phosphine‐Phosphoramidite Ligands for Highly Enantioselective Hydrogenation of N‐Arylimines.
Authors: Li Qing , Hou Chuan‐Jin , Liu Xiao‐Ning , Huang De‐Zhi , Liu Yan‐Jun , Yang Rui‐Feng , Hu Xiang‐Ping
Published: June 2015

The highly enantioselective asymmetric hydrogenation of N‐arylamines using chiral phosphine‐phosphoramidite ligands is demonstrated.
ChemInform Abstract: Palladium‐Catalyzed Oxidative C—C Bond Cleavage of α‐Hydroxyketones: Application to C—H Acylation of Azoarenes and Synthesis of a Liver(X) Receptor Agonist.
Authors: Majhi Biju , Ahammed Sabir , Kundu Debasish , Ranu Brindaban C.
Published: June 2015

Palladium‐catalyzed oxidative C—C cleavage of α‐hydroxyketones and 2‐aryl acetophenones in the presence of tert‐butyl hydrogen peroxide generates an acyl moiety, which promotes subsequent regioselective C—H acylation producing a series of ortho‐acyl substituted symmetrical and unsymmetrical azoarenes.
ChemInform Abstract: Dual‐Immobilized Copper Catalyst: Carbon Nitride‐Supported Copper Nanoparticles Catalyzed Oxidation of Propargylic Alcohols.
Authors: Lv Wei , Tian Jing , Deng Nan , Wang Yan , Zhu Xiaoshu , Yao Xiaoquan
Published: June 2015

The corresponding catalyst can be effectively recovered at least for three times without any decrease in the catalytic activity.
ChemInform Abstract: Ir‐Catalyzed Arylation, Alkylation of Quinones with Boronic Acids Through C—C Coupling.
Authors: Wang Dawei , Ge Bingyang , Ju Anqi , Zhou Yucheng , Xu Chongying , Ding Yuqiang
Published: June 2015

The utility of this method is demonstrated in the synthesis of β‐secretase 1 inhibitor (VIIa).
ChemInform Abstract: Direct Enantioselective Conjugate Addition of Carboxylic Acids with Chiral Lithium Amides as Traceless Auxiliaries.
Authors: Lu Ping , Jackson Jeffrey J. , Eickhoff John A. , Zakarian Armen
Published: June 2015

A broad spectrum of carboxylic acids can be successfully added to α,β‐unsaturated esters after functionalization with optically active auxiliaries of type CPA‐1 and CPA‐2.
ChemInform Abstract: Generation and Trapping of Ketenes in Flow.
Authors: Henry Cyril , Bolien David , Ibanescu Bogdan , Bloodworth Sally , Harrowven David C. , Zhang Xunli , Craven Andy , Sneddon Helen F. , Whitby Richard J.
Published: June 2015

Ketenes are generated in situ by thermolysis of ethoxyalkynes under flow conditions and trapped with amines or alcohols to form amides and esters respectively.
ChemInform Abstract: Thioboration of α,β‐Unsaturated Ketones and Aldehydes Toward the Synthesis of β‐Sulfido Carbonyl Compounds.
Authors: Civit Marc G. , Sanz Xavier , Vogels Christopher M. , Webb Jonathan D. , Geier Stephen J. , Decken Andreas , Bo Carles , Westcott Stephen A. , Fernandez Elena
Published: June 2015

The synthesis of β‐thio substituted carbonyl compounds is achieved by uncatalyzed reaction of α,β‐unsaturated carbonyl compounds with thiodioxaborolanes under mild reaction conditions.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Enantioselective Annulations: A Dual Activation Strategy for a Formal [4 + 2] Addition for Dihydrocoumarins.
Authors: Lee Anna , Scheidt Karl A.
Published: June 2015

The first general method for a highly efficient asymmetric annulation is presented that furnishes substituted dihydrocoumarins from simple precursors.
ChemInform Abstract: Synthesis of Pyrrolidine Derivatives by a Platinum/Broensted Acid Relay Catalytic Cascade Reaction.
Authors: Galvan Alicia , Calleja Jonas , Fananas Francisco J. , Rodriguez Felix
Published: June 2015

Various N‐Boc protected alkynamine substrates are treated with appropriate simple alkenes or alkynes and silane analogues (XIV) and (XVI).
ChemInform Abstract: P‐Stereogenic PNP Pincer‐Pd Catalyzed Intramolecular Hydroamination of Amino‐1,3‐dienes.
Authors: Yang Zehua , Xia Chao , Liu Delong , Liu Yangang , Sugiya Masashi , Imamoto Tsuneo , Zhang Wanbin
Published: June 2015

Allyl‐type chiral pyrrolidine derivatives are efficiently synthesized by asymmetric intramolecular hydroamination of amino‐1,3‐dienes with excellent regioselectivities and up to moderate enantioselectivities.
ChemInform Abstract: Further Exploration of the Heterocyclic Diversity Accessible from the Allylation Chemistry of Indigo.
Authors: Shakoori Alireza , Bremner John B , Abdel‐Hamid Mohammed K , Willis Anthony C. , Haritakun Rachada , Keller Paul A
Published: June 2015

Depending only on reaction time diverse indigo‐derived heterocycles are accessible.
ChemInform Abstract: Regioselective Catalytic Asymmetric C‐Alkylation of Isoxazolinones by a Base‐Free Palladacycle‐Catalyzed Direct 1,4‐Addition.
Authors: Hellmuth Tina , Frey Wolfgang , Peters Rene
Published: June 2015

The first examples of enantioselective C‐alkylations of isoxazolinones to give all‐carbon quarternary centers are reported using a planar chiral palladacycle catalyst.
ChemInform Abstract: Direct Arylation of Sydnones with Aryl Chlorides Toward Highly Substituted Pyrazoles.
Authors: Brown Andrew W. , Harrity Joseph P. A.
Published: June 2015

The direct Pd‐catalyzed arylation of C‐4 unsubstituted sydnones by using aryl chlorides and bromides as coupling partners is developed.
ChemInform Abstract: A Novel Prins Cascade Process for the Stereoselective Synthesis of Oxa‐bicycles.
Authors: Subba Reddy B. V. , Venkateswarlu A. , Sridevi B. , Marumudi Kanakaraju , Kunwar A. C. , Gayatri G.
Published: June 2015

Under extremely mild reaction conditions, E‐ and Z‐9‐methyldeca3,8‐dien‐1‐ols (I), (IV) undergo cyclization reactions with various aromatic aldehydes leading to the corresponding oxa‐bicycles with excellent selectivity.
ChemInform Abstract: Microwave‐Assisted Synthesis of Certain Pyrrolylpyridines, Some Derived Ring Systems and Their Evaluation as Anticancer and Antioxidant Agents.
Authors: Rostom Sherif A.F. , Bekhit Adnan A.
Published: June 2015

Resulting products are evaluated as antitumor and antioxidant agents.
ChemInform Abstract: Unprotected Xylose‐Derived Nitrone in Stereodivergent Synthesis of 4‐Hydroxypiperidine Enantiomers: Weak Lewis Acid Induced Alteration of Stereochemistry in 1,3‐Dipolar Cycloaddition.
Authors: Rowicki Tomasz , Malinowski Maciej , Gryszel Maciej , Czerwinska Karolina , Madura Izabela , Mironiuk‐Puchalska Ewa , Koszytkowska‐Stawinska Mariola , Sas Wojciech
Published: June 2015

The two‐step synthesis of chiral bicyclic products (III) and (IV) involves the conversion of substrate (I) into the corresponding hydroxylamine followed by in situ formation of a chiral nitrone and intramolecular 1,3‐dipolar cycloaddition.
ChemInform Abstract: Synthesis of 4‐Substituted Oxazolo[4,5‐c]quinolines by Direct Reaction at the C‐4 Position of Oxazoles.
Authors: Akula Mahesh , Thigulla Yadagiri , Davis Connor , Jha Mukund , Bhattacharya Anupam
Published: June 2015

The title compounds (III) are obtained by a modified Pictet‐Spengler method without the aid of any prefunctionalization.
ChemInform Abstract: Diastereodivergent Pictet—Spengler Cyclization of Bicyclic N‐Acyliminium Ions: Controlling a Quaternary Stereocenter.
Authors: de Carne‐Carnavalet Benoit , Krieger Jean‐Philippe , Folleas Benoit , Brayer Jean‐Louis , Demoute Jean‐Pierre , Meyer Christophe , Cossy Janine
Published: June 2015

The diastereoselectivity of the Pictet—Spengler cyclization of bicyclic N‐acyliminium ions that contain a 3‐azabicyclo[n.3.0]alkane core and an electron‐rich π‐nucleophilic moiety, such as an indol‐2‐yl, indol‐3‐yl, 1‐methylpyrrol‐2‐yl, or 3,5‐dimethoxyphenyl group, is examined.
ChemInform Abstract: Copper‐Catalyzed Aerobic C—H Trifluoromethylation of Phenanthrolines.
Authors: Zhu Cheng‐Liang , Zhang Yong‐Qiang , Yuan Yong‐An , Xu Hao
Published: June 2015

Depending on the substituents of the phenanthroline the trifluoromethylation proceeds regioselectively or provides a mixture of regioisomers [cf.
ChemInform Abstract: Cyclization Cascades via N‐Amidyl Radicals Toward Highly Functionalized Heterocyclic Scaffolds.
Authors: Fuentes Noelia , Kong Wangqing , Fernandez‐Sanchez Luis , Merino Estibaliz , Nevado Cristina
Published: June 2015

A variety of N‐(arylsulfonyl)acrylamides are used as substrates for the title reactions.
ChemInform Abstract: Copper(I) Iodide Catalyzed Synthesis of Fused Hexacyclic Pyrazolo[4,5,1‐de]quinolino[4,3,2‐mn]acridin‐14(11H)‐ones under Ligand‐Free Conditions.
Authors: Zhang Wen‐Ting , Chen Dong‐Sheng , Li Chao , Wang Xiang‐Shan
Published: June 2015

The synthesis is based on a one‐pot three component reaction of 2‐halogenated benzaldehydes, 1H‐indazol‐6‐amines and cyclohexane‐1,3‐diones.
ChemInform Abstract: An Efficient Iodine—DMSO Catalyzed Synthesis of Quinoxaline Derivatives.
Authors: Xie Caixia , Zhang Zeyuan , Yang Bingchuan , Song Gaolei , Gao He , Wen Leilin , Ma Chen
Published: June 2015

Various quinoxaline systems are obtained by a one‐pot, two‐step oxidation/cyclization sequence.
ChemInform Abstract: Facile Synthesis of Pyrazolo[1,5‐a]pyridopyrazin‐one via Smiles Rearrangement or Direct Cyclization.
Authors: Xiao Youxin , Zhang Zhicheng , Chen Yinbo , Shao Xusheng , Li Zhong , Xu Xiaoyong
Published: June 2015

Various biaryl lactams are conveniently obtained starting from readily available precursors.
ChemInform Abstract: Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime in a Microchemical System.
Authors: Zhang Jisong , Dong Chen , Du Chencan , Luo Guangsheng
Published: June 2015

ε‐caprolactam (II) is obtained from cyclohexanone oxime (I) using trifluoroacetic acid as catalyst under optimized reaction conditions.
ChemInform Abstract: Three Scandium Compounds with Unsaturated Coordinative Metal Sites — Structures and Catalysis.
Authors: Zhang Liying , Wang Li , Wang PengCheng , Song Tianyou , Li Da , Chen Xiaobo , Fan Yong , Xu Jianing
Published: June 2015

Three newly synthesized organo‐scandium compounds are tested as catalysts for the cyanosilylation of aromatic aldehydes.
ChemInform Abstract: Steroidal Alkaloids from Veratrum dahuricum (Turcz.) Loes. f. with Genotoxicity on Brain Cell DNA in Mice.
Authors: Cong Yue , Li Jing , Zhang Qing‐Chun , Guo Jing‐Gong , Li Sha‐Sha
Published: June 2015

Two new steroidal alkaloids (I), (II) are isolated together with four known compounds.
ChemInform Abstract: Aza‐Polycyclic Aromatic Hydrocarbons from Saruma henryi.
Authors: Ma Yangmin , Jia Qiangqiang , Wang Pengfei , Cheng Xiaowei , Kang Yongxiang
Published: June 2015

A new azafluoranthene alkaloid, sarumine (I), is isolated along with six known N‐containing derivatives of phenanthrenes from the whole herb of Saruma henryi.
ChemInform Abstract: Thrilling Strain! Donor—Acceptor‐Substituted Cyclobutanes for the Synthesis of (Hetero)Cyclic Compounds
Authors: Reissig Hans‐Ulrich , Zimmer Reinhold
Published: June 2015

Review: 21 refs.
ChemInform Abstract: Development of Chiral Sulfoxide Ligands for Asymmetric Catalysis
Authors: Trost Barry M. , Rao Meera
Published: June 2015

Review: 78 refs.
ChemInform Abstract: Advances in Tandem Reactions with Organozinc Reagents
Authors: Kim Ju Hyun , Ko Young Ok , Bouffard Jean , Lee Sang‐gi
Published: June 2015

Review: 118 refs.
ChemInform Abstract: C—H Bond Functionalization Based on Metal Carbene Migratory Insertion
Authors: Hu Fangdong , Xia Ying , Ma Chen , Zhang Yan , Wang Jianbo
Published: June 2015

Review: 32 refs.
ChemInform Abstract: Electronic Structures and Theoretical Modelling of Two‐Dimensional Group‐VIB Transition Metal Dichalcogenides
Authors: Liu Gui‐Bin , Xiao Di , Yao Yugui , Xu Xiaodong , Yao Wang
Published: June 2015

Review: 215 refs.
ChemInform Abstract: Gallic Acid: Prospects and Molecular Mechanisms of Its Anticancer Activity
Authors: Subramanian A. P. , John A. A. , Vellayappan M. V. , Balaji A. , Jaganathan S. K. , Supriyanto Eko , Yusof Mustafa
Published: June 2015

Review: 95 refs.
ChemInform Abstract: Stimuli‐Responsive Nanomaterials for Biomedical Applications
Authors: Blum Angela P. , Kammeyer Jacquelin K. , Rush Anthony M. , Callmann Cassandra E. , Hahn Michael E. , Gianneschi Nathan C.
Published: June 2015

Review: [205 refs.
ChemInform Abstract: Recent Advances in New Generation Dye Removal Technologies: Novel Search for Approaches to Reprocess Wastewater
Authors: Ahmad Akil , Mohd‐Setapar Siti Hamidah , Chuong Chuo Sing , Khatoon Asma , Wani Waseem A. , Kumar Rajeev , Rafatullah Mohd
Published: June 2015

Review: 177 refs.
nido‐Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase‐2
Authors: Neumann Wilma , Xu Shu , Sárosi Menyhárt B. , Scholz Matthias S. , Crews Brenda C. , Ghebreselasie Kebreab , Banerjee Surajit , Marnett Lawrence J. , Hey‐Hawkins Evamarie
Published: June 2015

Carbaboranes are increasingly studied as pharmacophores, particularly as replacements for aromatic systems. However, especially ortho‐carbaborane is prone to degradation of the cluster, which hampers biological application. This study demonstrates that deboronation of the cluster may not only lead to a more active analogue, but can also improve the solubility and stability of a carbaborane‐containing inhibitor. Notably, introduction of a nido‐dicarbaborate cluster into the cyclooxygenase (COX) inhibitor indomethacin results in remarkably increased inhibitory potency and selectivity for COX‐2 relative to the respective phenyl analogue. The first crystal structure of a carbaborane‐containing inhibitor bound to COX‐2 further reveals a novel binding mode for the inhibitor that is strikingly different from that of indomethacin. These results indicate that nido‐dicarbaborate is a promising pharmacophore that exhibits properties which are also highly beneficial for its introduction into other inhibitor classes.
Latest Developments in Metalloenzyme Design and Repurposing
Authors: Heinisch Tillmann , Ward Thomas R.
Published: June 2015

In the past decade, artificial metalloenzymes (AMEs) have emerged as attractive alternatives to more traditional homogeneous catalysts and enzymes. This microreview presents a selection of recent achievements in the design of such hybrid catalysts. These include artificial zinc hydrolases and metathesases, the heme‐protein repurposing for C–H, N–H, and S–H insertion reactions, novel light‐driven redox hybrid catalysts, novel scaffold proteins, and metallocofactor anchoring techniques and metalloenzyme models.
Scalable Enantioselective Synthesis of Fmoc‐β2‐Serine and Fmoc‐β2‐Threonine by an Organocatalytic Mannich Reaction
Authors: Meyer Daniel , Marti Roger , Seebach Dieter
Published: June 2015

The diastereoselective Mannich reaction of functionalized aldehydes, using a phenethylamine‐derived iminium precursor, by activation with prolines and prolinol derivatives have been studied. Optimized reaction conditions have been developed, allowing for scale‐up and preparation of γ‐amino alcohol derivatives on multi‐gram scale from β‐hydroxypropanal and ‐butanal, with diastereoselectivites of typically >73:27 and yields of >60 %. After chromatographic diastereoisomer separation, hydrogenolytic debenzylation, enantiomerically pure Fmoc‐β2‐Ser(tBu)‐OH and Fmoc‐β2‐Thr(tBu)‐OH were thus prepared on multi‐gram scale in 6 steps and with overall yields of 24 % and 10 %, respectively, starting from commercially available starting compounds.
Detection of cerebrospinal fluid leakage by specific measurement of transferrin glycoforms
Authors: Kwon Seok‐Joon , Zhang Fuming , Dordick Jonathan S. , Sonstein William J. , Linhardt Robert J.
Published: June 2015

A simple and rapid detection of cerebrospinal fluid (CSF) leakage would benefit spine surgeons making critical postoperative decisions on patient care. We have assessed novel approaches to selectively determine CSF β2‐transferrin (β2TF), an asialo‐transferrin (aTF) biomarker, without interference from serum sialo‐transferrin (sTF) in test samples. First, we performed mild periodate oxidation to selectively generate aldehyde groups in sTF for capture with magnetic hydrazide microparticles, and selective removal with a magnetic separator. Using this protocol sTF was selectively removed from mixtures of CSF and serum containing CSF aTF (β2TF) and serum sTF, respectively. Second, a two‐step enzymatic method was developed with neuraminidase and galactose oxidase for generating aldehyde groups in sTF present in CSF and serum mixtures for magnetic hydrazide microparticle capture. After selectively removing sTF from mixtures of CSF and serum, ELISA could detect significant TF signal only in CSF, while the TF signal in serum was negligible. The new approach for selective removal of only sTF in test samples will be promising for the required intervention by a spine surgeon.