bluuebunny/crossref_metadata_2025 huggingface dataset:
Elucidating the Mechanisms of Hugan Buzure Granule in the Treatment of Liver Fibrosis via Network Pharmacology
Authors: Zhu Yi , Qiao Ming , Yang Jianhua , Hu Junping
Published: November 2020

Objective. To holistically explore the latent active ingredients, targets, and related mechanisms of Hugan buzure granule (HBG) in the treatment of liver fibrosis (LF) via network pharmacology. Methods. First, we collected the ingredients of HBG by referring the TCMSP server and literature and filtered the active ingredients though the criteria of oral bioavailability ≥30% and drug‐likeness index ≥0.18. Second, herb‐associated targets were predicted and screened based on the BATMAN‐TCM and SwissTargetPrediction platforms. Candidate targets related to LF were collected from the GeneCards and OMIM databases. Furthermore, the overlapping target genes were used to construct the protein‐protein interaction network and “drug‐compound‐target‐disease” network. Third, GO and KEGG pathway analyses were carried out to illustrate the latent mechanisms of HBG in the treatment of LF. Finally, the combining activities of hub targets with active ingredients were further verified based on software AutoDock Vina. Results. A total of 25 active ingredients and 115 overlapping target genes of HBG and LF were collected. Besides, GO enrichment analysis exhibited that the overlapping target genes were involved in DNA‐binding transcription activator activity, RNA polymerase II‐specific, and oxidoreductase activity. Simultaneously, the key molecular mechanisms of HBG against LF were mainly involved in PI3K‐AKT, MAPK, HIF‐1, and NF‐κB signaling pathways. Also, molecular docking simulation demonstrated that the key targets of HBG for antiliver fibrosis were IL6, CASP3, EGFR, VEGF, and MAPK. Conclusion. This work validated and predicted the underlying mechanisms of multicomponent and multitarget about HBG in treating LF and provided a scientific foundation for further research.
Damage Control Management of Perforating Pyometra Presenting with Septic Shock after the Return of Spontaneous Circulation
Authors: Takamatsu Jumpei , Kang Jinkoo , Fukuhara Aya , Matsuda Tomoya , Ishida Tomo
Published: November 2020

Introduction. Perforation of pyometra is often severe but rare. We report a case of pyometra detected on second-look surgery in an elderly patient with life-threatening septic shock and cardiopulmonary arrest before hospital arrival. Case Presentation. A 70-year-old woman with cardiopulmonary arrest received adrenaline. Computed tomography revealed ascites, and abdominal paracentesis was performed to identify the cause of cardiopulmonary arrest. The ascitic fluid was purulent, and intraperitoneal infection was identified. Emergency exploratory laparotomy revealed pyometra. Conclusion. If perforated, pyometra may cause peritonitis and lethal septic shock. Not only gynecologists but also emergency physicians should be aware of this possibility. Moreover, patient education is necessary. In patients with cardiopulmonary arrest, diagnostic abdominal paracentesis should be performed when the sole imaging finding is ascites. Improving outcomes in patients with difficult-to-diagnose pyometra with cardiopulmonary arrest by implementing damage control strategies before hysterectomy is possible.
Stability Analysis for Nonlinear Impulsive Control System with Uncertainty Factors
Authors: Ren Zemin , Wen Shiping , Li Qingyu , Feng Yuming , Tang Ning
Published: November 2020

Considering the limitation of machine and technology, we study the stability for nonlinear impulsive control system with some uncertainty factors, such as the bounded gain error and the parameter uncertainty. A new sufficient condition for this system is established based on the generalized Cauchy–Schwarz inequality in this paper. Compared with some existing results, the proposed method is more practically applicable. The effectiveness of the proposed method is shown by a numerical example.
Protective Effect of miR-204 on Doxorubicin-Induced Cardiomyocyte Injury via HMGB1
Authors: Du Youyou , Liu Guanghui , Zhao Luosha , Yao Rui
Published: November 2020

The toxicity of doxorubicin (DOX) limits its clinical application. Nevertheless, at present, there is no effective drug to prevent DOX-induced cardiac injury. miR-204 is a newly discovered miRNA with many protective effects on cardiovascular diseases. However, little research has been done on the effects of miR-204 on DOX-induced cardiac injury. Our study is aimed at investigating the effect of miR-204 on DOX-induced myocardial injury. An adenoassociated virus system was used to achieve cardiac-specific overexpression of miR-204. Two weeks later, the mice were intraperitoneally injected with DOX (15 mg/kg) to induce cardiac injury. H9c2 myocardial cells were used to validate the role of miR-204 in vitro. Our study showed that miR-204 expression was decreased in DOX-treated hearts. miR-204 overexpression improved cardiac function and alleviated cardiac inflammation, apoptosis, and autophagy induced by DOX. In addition, our results showed that miR-204 prevented DOX-induced injury in cardiomyocytes by directly decreasing HMGB1 expression. Moreover, the overexpression of HMGB1 could offset the protective effects of miR-204 against DOX-induced cardiac injury. In summary, our study showed that miR-204 protected against DOX-induced cardiac injury via the inhibition of HMGB1, and increasing miR-204 expression may be a new treatment option for patients with DOX-induced cardiac injury.
Analysis of Crucial Genes and Pathways Associated with Spared Nerve Injury-Induced Neuropathic Pain
Authors: Mao Dong , Zhai Huang , Zhao Gang , Mi Jingyi , Rui Yongjun
Published: November 2020

Purpose. The study was aimed at elucidating the molecular mechanism underlying neuropathic pain induced by spared nerve injury (SNI). Methods. The microarray data of GSE30691 were downloaded from the Gene Expression Omnibus database, including sciatic nerve lesion samples at 3, 7, 21, and 40 days after SNI and sham control samples at 3, 7, and 21 days. Differential analysis along with Mfuzz clustering analysis was performed to screen crucial clusters and cluster genes. Subsequently, comprehensive bioinformatic analyses were performed, including functional enrichment analysis, protein-protein interaction (PPI) network and module analysis, and transcription factor- (TF-) gene and miRNA-target interaction predictions. Moreover, the screened differentially expressed genes (DEGs) were corroborated using two other microarray datasets. Results. Three clusters with different change trends over time after SNI were obtained. Protein kinase CAMP-activated catalytic subunit beta (Prkacb), complement C3 (C3), and activating transcription factor 3 (Atf3) were hub nodes in the PPI network, and fibroblast growth factor 9 (Fgf9) was found to interact with more TFs. Prkacb and Fgf9 were significantly enriched in the MAPK signaling pathway. Moreover, rno-miR-3583-5p was targeted by Fgf9, and rno-miR-1912-3p was targeted by neuregulin 1 (Nrg1). Key genes like Nrg1 and Fgf9 in cluster 1, Timp1 in cluster 2, and Atf3 and C3 in cluster 3 were screened out after corroborating microarray data with other microarray data. Conclusions. Key pathways like the MAPK signaling pathway and crucial genes like Prkacb, Nrg1, Fgf9, Timp1, C3, and Atf3 may contribute to SNI-induced neuropathic pain development in rats.
Evaluation and Management of Symptomatic Vasospasm following Endoscopic Endonasal Resection of Pediatric Adamantinomatous Craniopharyngioma
Authors: Hansen Dustin , Hidalgo Joaquin , Cohen Alan , Mukherjee Debraj , Scafidi Susanna
Published: November 2020

Background. Cerebral vasospasm is a well-described pathology following subarachnoid hemorrhage and trauma in children; however, very few cases have been published following craniopharyngioma resection in children. Those that were published were associated with significant morbidity or mortality at hospital discharge. Case Summary. Here, we report the challenging clinical course of a pediatric patient who developed delayed cerebral vasospasm following craniopharyngioma resection. It was first noted on postoperative day 13. The patient was managed with induced hypertension, hypervolemia, and intra-arterial vasodilator therapy (nicardipine). This patient made a full recovery without new focal deficits at hospital discharge. Conclusion. In contrast to previously reported similar pediatric cases, this patient with cerebral vasospasm after craniopharyngioma resection made a full recovery without new focal neurologic deficits. To our knowledge, this is the first occurrence of a patient with this clinical course.
Splay Toe after Freiberg-Köhler’s Osteonecrosis: A Case Report of a Successful Operative Treatment in a Rare Multiplanar Foot Deformity
Authors: Riegger Martin , Guidi Marco , Filardo Giuseppe , Candrian Christian
Published: November 2020

“Splay toe” is a rare deformity of the forefoot and often causes the occurrence of metatarsalgia and dysfunction while walking or weight bearing. Since it involves a deviation in the sagittal and transversal planes, often combined with a malrotation, surgical correction can be challenging. We describe a case of splay toe deformity in the forefoot causing metatarsalgia in a 62-year-old female patient with a former avascular osteonecrosis of the 2 metatarsal head Smillie stage V of Freiberg-Köhler’s disease causing a splay toe between the 2nd and the 3rd rays. There are only few reports in the literature, and a clear treatment strategy has not been defined, yet, although, it has been described that most of these patients are operated more than once. In the presented case, we performed a successful treatment by a combined surgical technique consisting in modified Weil’s osteotomy and the transfer of the extensor brevis tendon. We sustain that for correction of a multiplanar deformity of lesser toe deformities osseous correction as well as tendon transfer lead to successful therapy.
Semigroup Maximal Functions, Riesz Transforms, and Morrey Spaces Associated with Schrödinger Operators on the Heisenberg Groups
Authors: Wang Hua
Published: November 2020

Let

L
=
−

Δ

ℍ

n

+
V

be a Schrödinger operator on the Heisenberg group

ℍ

n

, where

Δ

ℍ

n

is the sub-Laplacian on

ℍ

n

and the nonnegative potential

V

belongs to the reverse Hölder class

B

q

with

q
∈

Q
/
2

,

∞

. Here,

Q
=
2
n
+
2

is the homogeneous dimension of

ℍ

n

. Assume that

e

−
t
L

t
>
0

is the heat semigroup generated by

L

. The semigroup maximal function related to the Schrödinger operator

L

is defined by

T

L

∗

f

u

≔

sup

t
>
0

e

−
t
L

f

u

. The Riesz transform associated with the operator

L

is defined by

R

L

=

∇

ℍ

n

L

−
1
/
2

, and the dual Riesz transform is defined by

R

L

∗

=

L

−
1
/
2

∇

ℍ

n

, where

∇

ℍ

n

is the gradient operator on

ℍ

n

. In this paper, the author first introduces a class of Morrey spaces associated with the Schrödinger operator

L

on

ℍ

n

. Then, by using some pointwise estimates of the kernels related to the nonnegative potential, the author establishes the boundedness properties of these operators

T

L

∗

,

R

L

, and

R

L

∗

acting on the Morrey spaces. In addition, it is shown that the Riesz transform

R

L

=

∇

ℍ

n

L

−
1
/
2

is of weak-type

1
,
1

. It can be shown that the same conclusions are also true for these operators on generalized Morrey spaces.
Edge Computing-Based ERBS Time Synchronization Algorithm in WSNs
Authors: Sun Xianbo , Su Yixin , Huang Yong , Tan Jianjun , Yi Jinqiao , Hu Tao , Zhu Li
Published: November 2020

In the practical application of large-scale photovoltaic module monitoring, adopting wireless sensor network (WSN) technology is a method worth researching. With increasing nodes in the wireless sensor network, widely existing clock skew, increased geometrically, is bringing about greater energy consumption. Due to the random distribution of nodes, in order to improve the transmission efficiency and reduce the computational load of the coordinator, the node processor needs to the use edge computing for preliminary analysis. This paper puts forward an improved energy-efficient reference broadcast synchronization algorithm (ERBS). This algorithm firstly calculates the average phase offset of nonadjacent nodes in the network after receiving a message. It then uses the least square method to solve the clock skew to achieve high-precision synchronization of the whole network. Simulation results show that compared with RBS, the time synchronization precision of ERBS is greatly improved and synchronization times are greatly reduced, decreasing energy consumption significantly.
Positioning Error Compensation for Industrial Robots Based on Stiffness Modelling
Authors: Li Yingjie , Gao Guanbin , Liu Fei
Published: November 2020

Insufficient stiffness of industrial robots is a significant factor which affects its positioning accuracy. To improve the positioning accuracy, a novel positioning error compensation method based on the stiffness modelling is proposed in this paper. First, the positioning errors considering the end load and gravity of industrial robots due to stiffness are analyzed. Based on the results of analysis, it is found that the positioning errors can be described by two kinds of deformation errors at joints: the axial deformation error and the radial deformation error. Then, the axial deformation error is modelled by the differential relationship of kinematics equations. The model of radial deformation error is deduced through the recurrence method and rotation transformation between joints. Finally, these two models are transformed into a Cartesian coordinate system, and a positioning error compensation method based on these two models is presented. Simulations based on the finite element analysis are implemented to verify the positioning error compensation method. The results show that the suggested method can efficiently predict the positioning error according to the gravity and loads, so that the positioning accuracy of industrial robots can be improved with the proposed method.
Nondestructive Testing for Wheat Quality with Sensor Technology Based on Big Data
Authors: Tian Yan-Ge , Zhang Zheng-Nan , Tian Shuang-Qi
Published: November 2020

Nondestructive testing with sensor technology is one of the fastest growing and most promising wheat quality information analysis technologies. Nondestructive testing with sensor technology benefits from the latest achievement of many disciplines such as computer, optics, mathematics, chemistry, and chemometrics. It has the advantages of simplicity, speed, low cost, no pollution, and no contact. It is widely used in wheat quality analysis and testing research. This article summarizes nondestructive testing with sensor technology for wheat quality, including the mechanical model, hyperspectral technology, Raman spectroscopy, and near-infrared techniques for wheat mechanical properties, storage properties, and physical and chemical properties (such as moisture, ash, protein, and starch) in the past decade. Based on the current research progress, big data technology needs a lot of research in spectral data mining, modeling algorithm optimization, model robustness, etc. to provide more data support and method reference for the research and application of wheat quality.
Rate Decline Analysis of Horizontal Wells with Multiple Variable Conductivity and Uneven Distributed Fractures
Authors: Hu Yunpeng , Cheng Ziyun , Ding Wei , Zhang Xiaoling , Qu Liangchao , Sun Chunliu , Su Penghui , Zhang Wenqi
Published: November 2020

In this paper, a new rate decline analysis model of horizontal wells with variable conductivity and uneven distribution of multiple fractures is proposed. By Laplace transformation, point source integration, and superposition principle, solutions of multiple infinite conductivity fractures in closed reservoirs are obtained. By coupling Fredholm integral equation of variable conductivity, linear equations of variable conductivity fractures in Laplace space are obtained. Gauss-Newton iteration, Duhamel convolution, and Stehfest numerical inversion method are used to obtain the bottom hole production solution. The accuracy of the results is verified by comparing with Eclipse software simulation. Then, the influence of some important reservoir and fracture parameters on the production is analyzed. The calculative results show that the smaller the fracture spacing is, the earlier the fracture begins to decline, the more the production will decrease; the change of different fracture length with the total fracture length unchanged has almost no effect on the production; the angle between fracture and

x

-axis has an important effect on the production; the smaller the angle between fracture and

x

-axis is, the stronger the interference between fractures is, the higher the production; the initial fracture conductivity affects the early production behavior, and the higher the initial fracture conductivity, the higher the production; the larger the fracture declines index, the lower the production, but the decreasing range gradually decreases with the increase of the decline index; the larger the reservoir drainage radius, the later the energy depletion stage, the higher the production. At last, a good fitting effect is obtained by fitting an example of oil field. The model proposed in this paper enriches the model base of rate decline analysis of fractured horizontal wells and lays a theoretical foundation for efficient development and practice of tight reservoirs.
Development of a RP-HPLC Method for Separating and Quantifying Muscimol in Different Developmental Stages of the Fungus Amanita muscaria
Authors: Ávila Emersón León , Guevara-Pulido James
Published: November 2020

A simple RP-HPLC method was designed for the quantification of muscimol (5-(aminomethyl)-isoxazol-3-ol) present in five aqueous extracts of Amanita muscaria each from a different developmental stage. Results show that the maximum concentration of muscimol (1,210 mg/ml) was found in the young mushroom stage of development. Moreover, it was also found that this concentration progressively decreases as the fungus ages. The developed method is a simple but effective method for the quantification of muscimol, a widely important metabolite for the pharmaceutical industry as a possible treatment for tardive dyskinesia and Parkinson’s disease.
Detecting Falsified Financial Statements Using a Hybrid SM-UTADIS Approach : Empirical Analysis of Listed Traditional Chinese Medicine Companies in China
Authors: Yang Ruicheng , Jiang Qi
Published: November 2020

By combining the similarity matching (SM) method with the utilities additives discriminates (UTADIS) method, we propose a hybrid SM-UTADIS approach to detect falsified financial statements (FFS) of listed companies. To evaluate the performance of this hybrid approach, we conduct experiments using the annual financial ratios of listed traditional Chinese medicine (TCM) companies in China. There are three stages in the detection procedure. First, we use the cosine similarity matching method to select matched companies for each considered company, derive the deviation data of each considered company as a sample dataset to capture the intrinsic law of the financial data, and further divide these into training and testing datasets for the next two stages. Second, we put the training dataset into the UTADIS to train the SM-UTADIS model. Finally, we use the trained SM-UTADIS model to classify the testing dataset and evaluate the performance of the proposed method. Furthermore, we use other approaches, such as single UTADIS and logistic and SM-logistic regression models, to detect FFS. By comparing these results to those of the hybrid SM-UTADIS approach, we find that the proposed hybrid approach greatly improves the accuracy of FFS detection.
The Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibits Cell Proliferation Induced by Estradiol on the Uterus and Vagina of Ovariectomized Female Wistar Rats
Authors: Wego Kamgaing Marius Trésor , Mvondo Marie Alfrede , Poualeu Kamani Sylviane Laure , Minko Essono Stéphane , Wansi Ngnokam Sylvie Lea
Published: November 2020

Proliferation is a cellular process strongly linked to the genesis of cancer. Natural substances with antiproliferative activities are currently potential alternatives in the treatment of cancers. Dacryodes edulis, for instance, is a medicinal plant traditionally used in the treatment of cancer. Scientific studies have reported the antioxidant activity of this plant. In addition, the presence of prostate cancer chemopreventive polyphenols was reported in D. edulis extracts. Therefore, this study was aimed to evaluate the effects of the aqueous extract of D. edulis leaves on cell proliferation induced by estradiol in ovariectomized female Wistar rats. In this regard, ovariectomized (OVX) rats were cotreated with estradiol valerate (E2V) (0.75 mg/kg) and the aqueous extract of D. edulis leaves. Control groups received either the vehicle (sham-operated animals and the OVX control), E2V (0.75 mg/kg) only, or E2V (0.75 mg/kg) and tamoxifen (10 mg/kg). Treatments were administered orally for 3 consecutive days, and animals were sacrificed thereafter. Epithelial heights of the uterus and vagina were assessed. Uterine levels of total cholesterol and estradiol were determined as well. Results showed that the aqueous extract of D. edulis leaves reversed the effects of estradiol as it reduced uterine weight (p<0.05), uterine (p<0.05), and vaginal (p<0.001) epithelium heights. This antiproliferative effect of D. edulis was associated with reduced tissue (uterine) levels of estradiol (p<0.001). These results suggest that the aqueous extract of D. edulis leaves could be a potential alternative treatment for proliferation-related diseases.
Computational Analysis on Numerical Simulation of Internal Flow Physics for Pump as Turbine in Renewable Small Hydro Energy Generation
Authors: Jianguo Du , Adu Daniel , Acheaw Emmanuel , Hafeez Shakir , Ofosu Antw Eric
Published: November 2020

Energy contributes significantly in almost all aspects of human life as well as economic activities and plays a crucial role in the infrastructural development of a county to alleviate poverty. Generating energy from a renewable source such as small hydropower through the application of pump operating as a turbine mode called Pump as Turbine is one of the best alternatives to provide clean and inexpensive energy. Using Pump as Turbine helps in generating reasonably priced hydroelectric power for communities in underdeveloped counties. This study investigates the effects of internal flow behaviour and performance of Pump as Turbine under different rotational speed and flow rate. The rotational speed is an essential physical parameter as it affects the Pump as Turbine operation. A model-specific speed centrifugal pump model with head 32 (m), flow rate of 12.5 (m3/h) and the rotational speed of 2900 rpm, has been selected for the study. Numerical simulations have been conducted using the k-ω turbulence model to solve three-dimensional (3D) equations. The pump mode experimental data were used to confirm the results for better analysis. The results predicted that vortex and turbulent kinetic energy increase per rotational speed increase. Also, at the higher rotational speed, very high recirculation of flow is detected at the blade suction chamber, although the pressure side has a smooth flow. This study provides beneficial information which will serve as a reference to help improve PAT performance along with selecting PAT for a small hydropower site. Future works will consider the impact of blade thickness and cavitation in Pump as Turbine.
Using the Same PayWord Chains Associated with a Single Account from Multiple Mobile Devices
Authors: Chang Tao-Ku , Yeh Fu-Hao
Published: November 2020

Customer awareness and interest in mobile payments are increasing. However, security and privacy risks remain major barriers to their adoption, with customers worrying about their personal data being hacked or intercepted. In this paper, we present the design of a secure scheme for mobile payments that can guarantee mutual nonrepudiation between the customer, merchant, and banker. A customer can use the proposed scheme to make a payment with the same PayWord chains of a single account from multiple devices.
Causes of Delay in the Construction Projects of Subway Tunnel
Authors: Zhang Dingbang , Zhang Hang , Cheng Tao
Published: November 2020

The constructions of urban infrastructure are an important sector that provides remarkable ingredients for the economic development of modern cities. However, a large number of transportation infrastructure construction projects are delayed; therefore, those projects always exceed their original time and cost estimates. So construction delay has been considered as a recurring problem in the construction projects of urban infrastructure, and it adversely affects the time, cost, safety, and quality of construction. This paper is committed to investigating the time performance of subway tunnel constructions in China to identify the causes of delay based on the questionnaire surveys of 87 tunnel consultants and 91 contractors, and a total of 49 delay causes of tunnel construction are identified one by one in this study. It can be concluded from this study that the six most severe delay causes are national policy for subway tunnel construction, complicated geological conditions, payment delays by owners, award projects to the lowest bid price, shortage of advanced large equipment, and low productivity of laborers. There is a relatively reliable agreement between the tunnel consultants and contractors of 76.3% on the ranking of different delay causes.
Galloping Stability and Wind Tunnel Test of Iced Quad Bundled Conductors considering Wake Effect
Authors: Liu Xiaohui , Zou Ming , Wu Chuan , Cai Mengqi , Min Guangyun , Yang Shuguang
Published: November 2020

A new quad bundle conductor galloping model considering wake effect is proposed to solve the problem of different aerodynamic coefficients of each subconductor of iced quad bundle conductor. Based on the quasistatic theory, a new 3-DOF (three degrees of freedom) galloping model of iced quad bundle conductors is established, which can accurately reflect the energy transfer and galloping of quad bundle conductor in three directions. After a series of formula derivations, the conductor stability judgment formula is obtained. In the wind tunnel test, according to the actual engineering situation, different variables are set up to accurately simulate the galloping of iced quad bundle conductor under the wind, and the aerodynamic coefficient is obtained. Finally, according to the stability judgment formula of this paper, calculate the critical wind speed of conductor galloping through programming. The dates of wind tunnel test and calculation in this paper can be used in the antigalloping design of transmission lines.
Feature Extraction Based on Non-Subsampled Shearlet Transform (NSST) with Application to SAR Image Data
Authors: Ding Huijie , Lin Arthur K. L.
Published: November 2020

Considering the defaults in synthetic aperture radar (SAR) image feature extraction, an SAR target recognition method based on non-subsampled Shearlet transform (NSST) was proposed with application to target recognition. NSST was used to decompose an SAR image into multilevel representations. These representations were translation-invariant, and they could well reflect the dominant and detailed properties of the target. During the machine learning classification stage, the joint sparse representation was employed to jointly represent the multilevel representations. The joint sparse representation could represent individual components independently while considering the inner correlations between different components. Therefore, the precision of joint representation could be enhanced. Finally, the target label of the test sample was determined according to the overall reconstruction error. Experiments were conducted on the MSTAR dataset to examine the proposed method, and the results confirmed its validity and robustness under the standard operating condition, configuration variance, depression angle variance, and noise corruption.
Altered Mental Status and Cyanosis in a Pediatric Patient with Methemoglobinemia
Authors: Grenz Phillip M. , Ray Jr. Robert N. , Hardy Olivia A. , Koons Andrew L. , Katz Kenneth D. , Romano Teresa M.
Published: November 2020

Methemoglobinemia results from increased amounts of oxidized hemoglobin in the blood with an ensuing change in oxygen dissociation curve and lack of oxygen delivery to tissue. A previously well, male toddler was brought to the Pediatric Emergency Department (PED) by Emergency Medical Services (EMS) with abrupt onset of altered mental status and cyanosis after a suspected ingestion of “Rush” nail polish remover. He was quickly diagnosed with methemoglobinemia by both clinical presentation and chocolate-colored blood appearance. He emergently received intravenous (IV) methylene blue (MB) with immediate and sustained improvement requiring no further doses. Though inhalation of nitrites and subsequent methemoglobinemia is frequently reported in adolescents, we were unable to find any cases in the literature detailing ingestion of this product and the resulting clinical manifestations. Our objective with this report is to describe a rare case of a toddler with an accidental ingestion of “Rush” nail polish remover, a nitrite compound. Our patient presented to the PED with abrupt onset of altered level of consciousness, hypotension, and cyanosis resulting from acquired methemoglobinemia. This case report demonstrates the importance of emergency clinicians being able to make clinical judgements and decisions based on the history and physical exam when methemoglobinemia is suspected.
Behavior Anomaly Detection in SDN Control Plane: A Case Study of Topology Discovery Attacks
Authors: Chou Li-Der , Liu Chien-Chang , Lai Meng-Sheng , Chiu Kai-Cheng , Tu Hsuan-Hao , Su Sen , Lai Chun-Lin , Yen Chia-Kuan , Tsai Wei-Hsiang
Published: November 2020

Software-defined networking controllers use the OpenFlow discovery protocol (OFDP) to collect network topology status. The OFDP detects the link between switches by generating link layer discovery protocol (LLDP) packets. However, OFDP is not a security protocol. Attackers can use it to perform topology discovery via injection, man-in-the-middle, and flooding attacks to confuse the network topology. This study proposes a correlation-based topology anomaly detection mechanism. Spearman’s rank correlation is used to analyze the network traffic between links and measure the round-trip time of each LLDP frame to determine whether a topology discovery via man-in-the-middle attack exists. This study also adds a dynamic authentication key and counting mechanism in the LLDP frame to prevent attackers from using topology discovery via injection attack to generate fake links and topology discovery via flooding attack to cause network routing or switching abnormalities.
Interactions among Cognitive Factors Affecting Unsafe Behavior: Integrative Fuzzy DEMATEL ISM Approach
Authors: Shakerian Mahnaz , Choobineh Alireza , Jahangiri Mehdi , Alimohammadlou Moslem , Nami Mohammad , Hasanzadeh Jafar
Published: November 2020

The prevention of industrial accidents is not completely practical by implementing safety programs unless focusing on protecting vulnerable workers. The unsafe behavior cognitive factors (UBCFs) are essential determinants contributing to human failure. This study aimed at eliciting the most important UBCFs, along with investigating hierarchical cause-effect interactions among them. A qualitative approach using metasynthesis was utilized to extract all essential UBCFs among industrial workplaces. Afterward, the relationships between UBCFs were recognized using the fuzzy decision-making trial and evaluation laboratory (DEMATEL) method and rated by an expert panel. Also, a hierarchical model was developed based on the final matrix of DEMATEL by employing the interpretive structural modeling (ISM) method. Ten criteria were extracted as UBCFs through the metasynthesis method. The threshold value was set as 0.175 in DEMATEL following experts’ ideas. Inadequacy of persons’ resilience and habitual rule ignorance were recognized as the most important predictive UBCFs. The developed model was tested through a case study in a petrochemical company. The results of the study can be used to help industrial managers and HSE practitioners to consider workers’ capabilities either cognitively or physically when designing the required tasks to reduce unsafe behaviors. Also, the findings of the study are applicable for other researchers to prioritize the most important factors affecting unsafe behavior in different workplaces.
Preparation of Microfiber Grating for Real-Time Sensing of Escherichia Coli Concentration
Authors: Qiu Qingyan , Dai Min , Luo Caidong , Mu Ying , Du Wei , Li Yu , Luo Jun , Li Rong
Published: November 2020

Various diseases are spread by means of contaminated water or food, and the detection of pathogenic bacteria has great significance for securing a proper healthy environment for human beings. In this article, microfiber gratings (MFGs) were fabricated by using a high-frequency CO2 laser. The number of periods is 30, and the length of the period is 600 μm. A type of biosensor is proposed in this study. Results showed that the biosensor was strongly sensitive to the concentration of Escherichia coli and a maximum sensitivity of 1.15 nm/107 CFU was achieved. The mechanism of real-time sensing of prepared MFG was also proposed, which could be due to relationship between dip wavelength shift and the concentration of detected bacteria. The prepared MFGs do not need any coating, and the proposed biosensor has a great potential for application in fields of medical treatment, biology, and farming.
Preventive Effect of Albumin Nano TPA Gene Plasmid Ultrasound Microbubble Carrier System on Thrombosis after Cardiac Valve Replacement
Authors: Qi Feng , Zhao Linlin , Cai Guohua , Sun Zhendong , Wu Naishi
Published: November 2020

After cardiac valve replacement, most patients will have different degrees of thrombosis, different parts of the thrombus, and even more frequent occurrence of postoperative thrombosis; therefore, the prevention of postoperative thrombosis is particularly important. The purpose of this study was to investigate the preventive effect of albumin nano tPA gene plasmid ultrasound microbubble carrier system on thrombosis, especially in cardiac valve. The experimental control method was used. Firstly, 11 dogs meeting the experimental requirements were selected. Secondly, the data of albumin nanoparticles and microbubbles were analyzed. The average size of albumin particles was 132.0 nm, the average size of microbubbles was 3.1 ± 1.6 μm, and the zeta potential was 13.70 ± 1.95 MV. The concentration of microbubbles was 4.2 ± 1.3 × 10/ml. Finally, 11 dogs were divided into two groups. The experimental group was treated with albumin nanoparticles ultrasound microbubble, and the others were the control group. It was found that the levels of tPA and D-dimer in the experimental group were significantly increased and maintained at a high level at 1 week after operation, and the prothrombin time was detected and the international normalized ratio was calculated at the same time. No significant changes were found in the experimental group.
A Systematic Review Comparing the Play Profiles of Children with Special Health Care Needs with Typically Developing Children
Authors: Munambah Nyaradzai , Cordier Reinie , Speyer Renée , Toto Sivuyisiwe , Ramugondo Elelwani L.
Published: November 2020

Introduction. Although play has been used as a means to meet therapeutic goals by health care practitioners for a long time, there is a need to continuously review its conceptualisation and use in everyday practice to promote evidence‐based practice. This systematic review aimed to evaluate the evidence on how the play of children with Special Health Care Needs (SHCN) is similar or different to that of typically developing children. Methods. Guided by the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) statement, we conducted a comprehensive review across five electronic databases for all studies that compared how the play of children with SHCN was similar or different to that of typically developing children. Data were extracted from the included studies, and methodological quality was assessed. Results. Eighteen studies met eligibility criteria. All the studies in this review were at risk of bias due to the study design. There was great variation in sample sizes, ranging between five and 112 participants in the diagnostic groups and five and 546 participants in control groups (typically developing children). The included studies investigated different aspects of play, which made it difficult to synthesise. However, of the 18 studies reviewed, thirteen reported that children with SHCN engage in less play, compared with typically developing children. Conclusions. Evidence supports the assumption that children with SHCN are less playful and spend less time engaging in play compared with typically developing children. This systematic review reveals paucity of research on play for children with several common chronic conditions such as HIV/AIDS, cancer, and cardiovascular diseases. Future studies need to reduce risks of bias, including the use of appropriate sample sizes, and must provide detailed results after investigating play in children with SHCN.
Three-Parameter Logarithm and Entropy
Authors: Corcino Cristina B. , Corcino Roberto B.
Published: November 2020

A three-parameter logarithmic function is derived using the notion of

q

-analogue and ansatz technique. The derived three-parameter logarithm is shown to be a generalization of the two-parameter logarithmic function of Schwämmle and Tsallis as the latter is the limiting function of the former as the added parameter goes to 1. The inverse of the three-parameter logarithm and other important properties are also proved. A three-parameter entropic function is then defined and is shown to be analytic and hence Lesche-stable, concave, and convex in some ranges of the parameters.
Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam
Authors: Hoang C. Q. , Nguyen H. D. , Ho N. X. , Vu T. H. T. , Pham T. T. M. , Nguyen K. T. , Nguyen H. T. , Hoang L. T. , Clapham H. , Nguyen T. T. T. , Phan L. T.
Published: November 2020

Background. Scarce information exists about immunity to hand, foot, and mouth disease (HFMD) among household contacts of index cases in Vietnam and what that means for reducing ongoing HFMD transmission in the community. Methods. We analyzed neutralizing antibodies (NT) and the incidence of enterovirus (EVs) infection among household contacts of index cases in a province where HFMD remains endemic. Throat swab and 2 mL blood samples from household contacts were collected at enrollment, during and after 2 weeks follow‐up. Results. The incidence of EV‐A71 infection among household contacts was 40/84 (47.6%, 95% Cl: 36.9‐58.3%), compared with 106/336 (31.5%, 95% Cl: 26.6‐36.5%) for CV‐A6 and 36/107 (33.6%, 95% Cl: 24.7‐42.6%) for CV‐A16. The incidence of CV‐A6 infection was fairly constant across ages; in contrast, CV‐A71 and CV‐A16 had some variation across ages. At baseline, higher geometric mean titer (GMT) of EV‐A71, CV‐A6, and CV‐A16 antibody titers was found for 25‐34‐year groups (range 216.3 to 305.0) compared to the other age groups. There was a statistically significant difference in GMT values of CV‐A6 and CV‐A16 between those who had an infection or did not have infection among households with an index case of these serotypes. Conclusions. Our results indicated that adults were becoming infected with HFMD and could be contributing to the transmission. There is, therefore, a need for considering the household setting as an additional target for intervention programs for HFMD.
Legislação sobre escravidão no Reino e na América portuguesa
Authors: Chignoli Daniel Nogueira
Published: November 2020

O artigo apresenta uma análise das fontes primárias, nomeadamente as Ordenações Filipinas, que regulavam a escravidão no Reino e na América portuguesa, bem como tem por objetivo retratar a dicotomia entre as formas jurídicas em que o escravo aparece como sujeito de direito e como objeto de direito.
Direito de preempção: as diversas espécies de preferência no direito civil
Authors: Jafet Danilo Haddad
Published: November 2020

O presente artigo abordará as espécies mais relevantes de direito de preempção ou preferência no Direito Civil brasileiro, passando, inicialmente, pela preempção convencional, momento em que serão traçados os principais aspectos do instituto da preempção. Em seguida, serão estudadas as preempções do condômino, do coerdeiro, do locatário, do arrendatário e, por fim, o instituto da retrocessão.
A necessidade de exigência de estudo e relatório de impacto ambiental sobre a condição laboral daqueles que integram a força produtiva do empreendimento
Authors: Matos Larissa Lopes
Published: November 2020

O artigo busca analisar a possibilidade de se exigir o Estudo de Impacto Ambiental (EIA) e Relatório de Impacto Ambiental (RIMA) no tocante ao meio ambiente do trabalho, notadamente em relação aos aspectos que norteiam a saúde e segurança do trabalhador, para a liberação de atividade empresarial, diante do fato desses instrumentos serem utilizados hoje apenas para avaliar os aspectos relacionados à natureza verde.
A falácia da despedida imotivada no Brasil
Authors: Carvalho Augusto Xavier de
Published: November 2020

Levando-se em consideração que, historicamente, grandes perturbações sociais ocorreram em razão de problemas ligados ao trabalho, e que o desemprego é um dos principais problemas de uma sociedade capitalista, buscou-se elucidar um dos papéis fundamentais do Direito do Trabalho, qual seja, evitar o desemprego e a rotatividade desmedida da mão de obra. Neste sentido, desconstrói-se a teórica contemporânea que considera a despedida arbitrária como sinônimo de despedia imotivada, trazendo à tona as ilegalidades possibilitadas por este tipo de cessação do contrato de trabalho, buscando, ainda, demonstrar os vários motivos que justificam a imediata vedação à despedida arbitrária no Brasil, sob análises constitucionais, convencionais, principiológicas, internacionalistas, humanitárias e até mesmo, civilistas, para evitar, assim, o retrocesso social.
O papel do STF na concepção distorcida do domínio do fato. Como a Ação Penal 470 inaugurou um entendimento equivocado da teoria na doutrina e jurisprudência brasileiras
Authors: Silva Marcela Oliveira
Published: November 2020

Este artigo pretende analisar o julgamento da Ação Penal 470, sob a perspectiva de qual o entendimento apresentado pelos ministros do Supremo Tribunal Federal a respeito da teoria do domínio do fato. Nosso objetivo não é fazer um exame dos fatos, tampouco dos resultados a que chegaram os ministros, e sim procurar buscar qual a perspectiva sustentada pelos ministros sobre o domínio do fato. Para isso, introduziremos breves considerações a respeito da teoria e, sem seguida, seguiremos para análise do acórdão.
Anthony Giddens e Niklas Luhmann: o direito como fórmula generalizável
Authors: Tiveron Julia Martins
Published: November 2020

A teoria social encontra-se em um momento de revisão, no qual novos conceitos devem ser formulados para trazê-la ao contexto atual. Essa ideia apresenta-se nas construções expostas pelos dois autores que se pretende abordar nesse artigo. Anthony Giddens e Niklas Luhmann pertencem a tradições sociológicas distintas e muitas são as divergências entre seus trabalhos, tal como procura-se aqui demonstrar. Apesar disso, identifica-se a existência de convergências no que se refere a suas preocupações e aos temas dos quais ambos se ocuparam. Nesse sentido, depreende-se que um tratamento conjunto faz-se proveitoso. Assim, destaca-se o exame de cada um acerca do tema da institucionalização, o que leva a considerações propostas no que se refere ao Direito e ao seu papel na sociedade contemporânea.
Mediação no ensino médio público: uma abordagem interdisciplinar entre o direito à educação e a antropologia jurídica, a partir do pensamento de Étienne Le Roy
Authors: Annunciato Marcia Aparecida da Silva
Published: November 2020

Nesta pesquisa interdisciplinar entre o direito à Educação, em seu âmbito constitucional, e a Antropologia Jurídica, a partir da Teoria do Multijuridismo proposta por Étienne Le Roy, buscou-se sustentar a hipótese de que em relações sociais continuadas, a mediação ocorre mais nos limites dos modelos de conduta e comportamento e sistemas de disposições duráveis do que da regulação estatal. O artigo desenvolve-se por meio da análise comparativa entre dispositivos legais de interesse do ensino médio público e os principais elementos do referencial teórico, em especial a noção de juridicidade e a mediação. Os resultados obtidos, ainda que parciais, indicam que a comprovação da hipótese inicial demanda maior aprofundamento teórico e pesquisa de campo. Contudo, os mesmos resultados indicam o grande potencial de contribuição da obra de Étienne Le Roy para o desvelamento de novas formas de abordagem e concreção da regulação estatal da Educação do Brasil.
Adoções, transferências forçadas e genocídio
Authors: Zen Cássio Eduardo
Published: November 2020

O artigo busca apresentar a transferência forçada de pessoas realizada por meio de processos aparentemente lícitos de adoções, como mecanismo de genocídio. Para tanto, o artigo irá além do mero texto legal do Estatuto de Roma, para se verificar casos históricos e situações que, mesmo com a aparência de programas oficiais de adoção, nada mais eram do que genocídios disfarçados de programas em favor de crianças. Apesar de a adoção ser um dos institutos mais nobres do direito, datando de tempos antigos, houve momentos e locais históricos nos quais a adoção forçada serviu para políticas estatais de higienização social, com efeitos que perduram.
Responsabilidade de proteger: minorias e genocídio
Authors: Santos Marco Aurélio Moura dos , Pili Frédéric Walthère Joachim
Published: November 2020

Este artigo busca esclarecer o conceito de responsabilidade de proteger com base na defesa de minorias e luta contra o genocídio na região de Darfur no Sudão. Haverá uma breve análise do andamento dos procedimentos no Tribunal Penal Internacional (TPI).
A proteção de dados pessoais e seus desafios regulatórios
Authors: Silva Mayara Rocumback Vieira da
Published: November 2020

Na atual sociedade da informação, ferramentas poderosas de tratamento de dados pessoais foram criadas, por meio das inovações tecnológicas, dominadas por interesses mercadológicos e pela lógica de coletar volumes exponenciais de dados. Tal cenário coloca em risco a proteção de dados pessoais, observado o descompasso entre a sofisticação do processamento de dados e as técnicas e instrumentos que visam a resguardar os interesses de seus titulares. Nesse contexto, este artigo tem por objetivo discutir algumas limitações da autodeterminação informacional e quais são as possíveis alternativas ou complementações a esse modelo. Para isso, foi abordada, sinteticamente, a estrutura do mercado de dados pessoais, elencando-se alguns modos de coleta de dados e riscos decorrentes de violação à privacidade. Em seguida, discutiu-se a relação entre privacidade e proteção de dados pessoais e como essa é prevista pelo ordenamento jurídico brasileiro, em especial, pela Lei n. 13.709/2018. Foram analisados também os aspectos relacionados à chamada crise do consentimento. Por fim, foi examinado como a regulação de risco é importante para a proteção de dados pessoais, em uma dimensão coletiva. Assim, concluiu-se que o consentimento como modo de legitimar a proteção de dados pessoais está sendo usado para além de suas capacidades e que, embora a Lei n. 13.709/2018 represente um avanço no tema, é necessário pensar como ela será interpretada e implementada. Diante disso, a visão da privacidade, por meio do caráter coletivo, integrando-se normas, como a Lei n. 13.709/2018, com propostas de responsabilidade demonstrável das empresas e privacidade “by design”, é essencial para a proteção de dados pessoais.