bluuebunny/crossref_metadata_2025 huggingface dataset:
A clinical case of the effective combined use of BCL-2 and PI3K inhibitors in the treatment of a patient with an unfavorable chronic lymphocytic leukemia with transformation into diffuse large B-cell lymphoma (Richter’s syndrome)
Authors: Rukavitsyn O. A. , Pop V. P. , Drozd M. V. , Ryabukhina Yu. E.
Published: November 2022

Understanding the molecular biological basis of chronic lymphocytic leukemia (CLL) pathogenesis and stratification of patients into risk groups has now led to significant advances in treatment. New targeted drugs with different mechanisms of action (bruton’s tyrosine kinase inhibitors, bCL-2 inhibitors, pI3K inhibitors) have significantly improved the prognosis of high-risk CLL patients. In some CLL cases the nodular tumor component can change to a more aggressive subtype of lymphoma (often diffuse large b-cell) with preservation of the small-cell leukemic component with the CLL phenotype (Richter’s syndrome), usually characterized by rapid progression and poor prognosis. The issue of treatment efficacy in patients with Richter’s syndrome still remains unresolved. The results of new drugs clinical trials are often contradictory and cannot yet be recommended for routine use in clinical practice. The low incidence of Richter’s syndrome, the lack of a unified view of the pathogenesis and therapy approaches make the search for effective drugs an urgent task, so each clinical observation is of undoubted interest.A clinical case of CLL patient with unfavorable molecular cytogenetic risk and transformation into diffuse large b-cell lymphoma (Richter’s syndrome) is presented. The combined use of bCL-2 inhibitors (venetoclax) and pI3K (duvelisib) led to the achievement of partial remission followed by a gradual increase in the positive antitumor effect.
Kikuchi–Fujimoto disease: literature review and report of four cases
Authors: Potapenko V. G. , Baykov V. V. , Markova А. Yu. , Mikhailova N. B. , Ter‑Grigoryan A. S. , Krivolapov Yu. А.
Published: November 2022

Kikuchi–Fujimoto disease, or necrotizing histiocytic lymphadenitis, is one of the rare causes of benign lymphadeno-pathy. The diagnosis is based on histological and immunohistochemical analysis of the lymph node biopsy. The article presents four clinical cases of Kikuchi–Fujimoto disease. According to the results of the primary analysis of lymph node tissue three patients were misdiagnosed with lymphoma. due to the unusual for lymphoid malignancy course the primary material was reviewed. The diagnosis of Kikuchi–Fujimoto disease was put. In three patients the disease has a re-current course. during the observation period, the course of the disease in all the presented patients is benign with normal quality of life.
Academic Achievement of Students in Schools with High Numbers of Migrant Children
Authors: Khukhlaev O.E. , Chibisova M.Y.
Published: November 2022

The article presents the results of studying the relationship between the academic achievements of students and the number of migrant children studying with them. The presented review of studies conducted on various ethno-cultural and national samples shows the ambiguity of this relationship. The authors analyzed statistical data on the ratio of children of foreign citizens in the region, as well as on the number of educational organizations with different ratios of children of foreign citizens in relation to schoolchildren with Russian citizenship. These indicators were compared with the assessment of the quality of education, for which the overall indicator of the education quality in the Russian regions presented by Rosobrnadzor was used, as well as with the index of the socio-economic situation in the regions. Analysis of data from the 85 regions of the Russian Federation showed that the ratio of migrant students (foreign citizens) in Russia to students with Russian citizenship in general education institutions is not related to the quality of education in the region considering its socio-economic situation. Basing on the results of discussion and comparison with the data of the world-wide research, we conclude that the concentration of migrant children in an educational institution should not act as a significant marker of educational policy in this area.
On the Assocıated Curves of a Frenet Curve in R_1^4
Authors: ÇİÇEK ÇETİN Esra , BEKTAŞ Mehmet , YILMAZ Münevver Yıldırım
Published: November 2022

In the present work, we have dealt with the properties of associated curves of a Frenet curve in R14. In addition to this, we define principal direction curve, B_1 -direction curve, B_2- direction curve of a given Frenet curve by using integral curves of 4-dimensional Minkowski space. Then we introduce some characterizations for general helix and slant helix. Finally, some new associated curves and theorems obtained for space-like curves and time- like curves in R14. Also, an example is given.
Solving the Generalized Rosenau-KdV Equation by the Meshless Kernel-Based Method of Lines
Authors: ARI Murat , KARAMAN Bahar , DERELİ Yılmaz
Published: November 2022

This current investigation consists of the numerical solutions of the Generalized Rosenau-KdV equation by using the meshless kernel-based method of lines, which is a truly meshless method. The governing equation is a nonlinear partial differential equation but the use of the method of lines leads to an ordinary differential equation. Thus, the partial differential equation is replaced by the ordinary differential equation. The numerical efficiency of the used technique is tested by different numerical examples. Numerical values of error norms and physical invariants are compared with known values in the literature. Moreover, Multiquadric, Gaussian, and Wendland’s compactly supported functions are used in computations. It is seen that the used truly meshless method in computations is very effective with high accuracy and reliability.
Peculiarities of carbamazepine pharmacogenetics and the most common adverse drug reactions during its use (literature review)
Authors: Skryabin Valentin Yu. , Zastrozhin Mikhail S. , Bryun Evgeny A. , Sychev Dmitry A.
Published: November 2022

Carbamazepine is widely used for the treatment of epilepsy, trigeminal neuralgia and psychiatric disorders. However, therapy is often ineffective, and some patients experience adverse drug reactions, which negatively affect both the efficacy and safety of therapy.
This review systematized and presented up-to-date information regarding the pharmacokinetics and pharmacogenetics of carbamazepine, as well as the most common adverse drug reactions arising from its use. Knowledge of the pharmacokinetics, pharmacodynamics and pharmacogenetics of carbamazepine is necessary to assess the effect of genetically determined activity of cytochrome P450 isoenzymes on the efficacy and safety of this drug. This will make it possible to develop approaches to personalizing the selection of an effective and safe dose of therapy in patients based on individual clinical and biological parameters.
The effect of neuropeptide ACTH4-10 on the adaptation of patients to dental prostheses according to the data of monitoring the emotional state using a polygraph
Authors: Pozhilova Elena V. , Novikov Vasiliy E. , Evseev Andrey V. , Abolmasov Nikolay N.
Published: November 2022

BACKGROUND: Monitoring and pharmacological correction of adaptation of patients to full removable dental prostheses is actual and practically important problem in stomatology.
AIM: To study the effect of neuropeptide ACTH4-10 on the process of adaptation of patients to complete removable prostheses by monitoring the emotional state using a polygraph.
MATERIALS AND METHODS: Examination and primary prosthetics with full removable dentures of patients (6075 years old) were performed of both sexes with total adentia. All patients were divided into three groups: the main group (correction of the adaptation process with ACTH4-10 neuropeptide Semax 0.1% nasal drops), the comparison group (0.9% NaCl solution was administered intranasally) and the control group (without pharmacological correction). Monitoring of the process of adaptation to prostheses was carried out by registering the emotional reaction of patients to the movements of the lower jaw with the help of a polygraph Barrier-14 of the company Antey (Russia).
RESULTS: The emotional state of patients in the main observation group who received pharmacological correction with ACTH4-10 neuropeptide reaches the values of adapted patients for most of the studied indicators within 714 days after the application of prostheses, and a month after the application of prostheses - for all studied indicators of the curves of the trajectories of the lower jaw (p 0.05), which cannot be noted in patients of the comparison group (NaCl) and the control group. The results obtained indicate a positive effect of the neuropeptide ACTH4-10 on the process of getting used to patients with complete removable prostheses.
CONCLUSIONS: Neuropeptide ACTH4-10 accelerates the process of adaptation of primary prosthetic patients to complete removable dental prostheses according to the monitoring of the emotional background of patients. The method of registering the emotional state of patients using a polygraph allows us to make an objective conclusion about the effect of occlusion and articulation on the psycho-emotional background and judge the patient's adaptation to a dental prosthesis.
Effect of Serratula marginata dry extract on the mice thymus and spleen structure in cyclophosphamide immunosuppression
Authors: Razuvaeva Yanina G. , Khobrakova Valentina B. , Budatsyrenova Ayuna Ts. , Olennikov Daniil N.
Published: November 2022

BACKGROUND: The search of effective and safe drugs to prevent and treating the immune deficient states is an actual problem of modern medicine.
AIM: The purpose of the study is to evaluate the effect of Serratula marginata dry extract on structure of mice thymus and spleen at cyclophosphamide immunosuppression.
MATERIALS AND METHODS: The experiments were carried out on F1 (CBAxC57Bl/6) mice. Immune deficiency was simulated by a single intraperitoneal introduction of cyclophosphamide in the dose 250 mg/kg. S. marginata dry extract in the dose 100 mg/kg was administered to animals for 14 days intragastrically against cyclophosphamide. Morphological studies of the thymus and spleen were performed on day 16 after the extracts administration. Areas white and red pulp of the spleen; the area of the thymic lobule, the cortex and the medulla; the density of cells in the subcapsular zone and the deep layers of the cortex were measured using the Zen 2012 image analysis program.
RESULTS: The S. marginata extract limited the development of involutive changes in the thymus caused by cyclophosphamide: the thymus area was by 28% (p 0.05) higher and the cortical-medullary index was (ratio of the cortex area to the medulla area) by 26% higher. The number of mitotically dividing cells, blasts and large lymphocytes increased, the number of cells with structural disorders and macrophages decreased in the thymus cortex. In animals of the experimental groups, the white pulp area was 47% (p 0.05) higher than that in the control.
CONCLUSIONS: The S. marginata dry extract limited the development of involutive processes in the thymus and spleen caused by the introduction of cytostatic cyclophosphamide.
Antihypoxic activity and anti-ischemic effect of complex herbal remedy
Authors: Gulyaev Sergey M. , Zhalsanov Yuriy V. , Turtueva Tatiana A. , Nikolaeva Galina G.
Published: November 2022

The present study was carried out to determine the antihypoxic and anti-ischemic effects of a polyherbal extract from Astragalus membranaceus, Scutellaria baicalensis and Phlojodicarpus sibiricus. The Wistar rats of both sexes were used in the study. The antihypoxic activity of the extract was studied using hemic and hypobaric models of hypoxia. The anti-ischemic effect of the extract was evaluated by the severity of neurological deficit and survival within 24 hours in model of bilateral occlusion of the common carotid arteries.
The course administration of the extract (100, 200 mg/kg) had an antihypoxic effect in the model of hemic hypoxia: the reserve time of life increased by 26 and 28%, respectively, compared with the control. The course introduction of the extract at doses of 50, 100 and 200 mg/kg increased the reserve time of life in hypobaric hypoxia by 12.3, 15.5 and 16.7%, respectively, compared with the control
The administration of the extract (100 and 200 mg/kg) in the model of cerebral ischemia had a cerebroprotective effect: the indicators of neurological deficit were, respectively, less than the control by 34 and 46%, and their survival was 62 and 64%, respectively, against 20% of the survival of rats in the control group. The results of the conducted studies suggest the prospects for further study of the plant extract as a cerebroprojector agent.
A Pipeline for the Creation of Biophysically Realistic Multicompartment Models of Drosophila melanogaster Descending Neurons
Authors:   , Vasserman Alexander Nicholas , Ausborn Jessica , von Reyn Catherine R.
Published: November 2022

Sensorimotor transformations are neural computations that convert high-dimensional sensory input into motor commands. Understanding how this conversion occurs will give insight into how organisms select appropriate behaviors in response to sensory stimuli. In the Drosophila melanogaster escape circuit, sensorimotor transformations occur in descending neurons (DNs) that receive inputs from feature encoding visual projection neurons (VPNs) and convey motor commands onto downstream motor circuits. This pivotal role, together with a rich suite of genetic and electrophysiological tools, makes DNs ideal models for sensorimotor transformations. We recently identified a bilateral pair of DNs (DNp03) that exhibits persistent activity (PA) when presented with visual inputs that mimic the looming shadow of a predator. The role of PA in transforming looming evoked sensory inputs into coordinated motor outputs in DNp03, however, is unknown. Detailed biophysical multicompartment models can be powerful tools to study how electrophysiological characteristics of a neuron such as PA shape its computations. As a first step, we develop a pipeline to create biophysically accurate computational models of Drosophila neurons and validate it by developing a model of DNp03. Utilizing this model we investigate the organization of sensory inputs DNp03 receives from VPNs and analyze their passive propagation. To guide implementation of active properties we use selective fluorescent labeling of sodium channels in DNp03 and discover its putative spike-initiation zone. The model can now be used to investigate the role of individual ion channels in sensorimotor integration and the modeling pipeline will enable the fast implementation of model neurons in the future.
Antibacterial Effects of Phlomoides molucelloides (Bunge) Salmaki
Authors: AL KATEEB Anfal Izaldeen , TÜFEKCİ Enis Fuat , BALOĞLU Mehmet Cengiz , ZENGİN Gokhan , YILDIZTUGAY Evren , ÇELİK ALTUNOĞLU Yasemin
Published: November 2022

The insufficiency of existing antibiotics in the combat against antibiotics-resistant bacteria has necessitated the discovery of new and effective antibacterial drugs. The discovery that bacteria synthesize various virulence factors by the quorum sensing system has suggested that quorum sensing inhibitors may be used in the fight against infectious diseases. This study aimed to determine the antibacterial and anti-quorum sensing activities of methanol and water extracts of aerial and root parts of Phlomoides molucelloides (Bunge) Salmaki. The minimal inhibitory concentration (MIC) values of the extracts were investigated against reference bacterial strains using the broth microdilution method. Anti-quorum sensing activities were examined by violacein and pyocyanin pigments inhibition and swarming motility inhibition assays against Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PAO1 bioreporter strains. The antibiofilm activities of the extracts were tested against P. aeruginosa PAO1 using the crystal violet staining method. The MIC value (> 2000 µg/mL) of all extracts against the tested bacteria could not be determined at the concentrations studied. All extracts partially inhibited the swarming motility of P. aeruginosa. Methanol extract of the aerial part inhibited pyocyanin production by 81.7% without interfering with P. aeruginosa growth. The extracts had no significant inhibitory activity on biofilm formation and violacein pigment production. These results showed that the extracts of P. molucelloides may be good anti-quorum sensing agents. Further research can be done to elucidate the mechanisms underlying these biological activities.
1909 ÇAĞA YANGINI VE REŞADİYE (YENİÇAĞA) KASABASININ KURULUŞU
Authors: YALDIRAK Tarık
Published: November 2022

Bolu sancağının Gerede kazasına bağlı Çağa kasabası, üç tepe arasında ve gayet dar bir vadi üzerindedir. Kasabada ilki 1879 civarında, 1901 ve 1909 yıllarında olmak üzere otuz yıl zarfında üç yangın meydana gelmiştir. Son yangında kasabanın büyük bir kısmı yok olmuştur. İlk müdahale 80 kadar çadırı bölgeye ulaştıran askeriye tarafından yapılmıştır. Akabinde çevre mahallerden yardım toplanarak açıkta kalan ahalinin barınması ve günlük iaşesinin sağlanmasına çalışılmıştır. Ayrıca içinde bulundukları durum merkezi yönetime bildirilerek yardım istenmiştir. Diğer taraftan taşra yönetimi sık yaşanan yangınlardan dolayı, yangınzedeler için, Gölağzı mevkiinde “Reşadiye” adında bir kasaba kurulmasını talep etmiştir. Ancak gerekli izin ve yardımlar geç geldiğinden, ahali 1910 kışını çadırlarda ve kulübelerde geçirmek zorunda kalmıştır. Yangında evini kaybeden her aileye, evlerini yeniden inşa etmeleri için, devlet hazinesinden 2.000 kuruş yardım verilmiştir. İlaveten kasabanın inşasında kullanılmak üzere, umumi ihtiyaçlar için 132.000 kuruş destek talep edilmiş, bu meblağ merkezi yönetim tarafından yüksek görülerek daha cüzi bir miktar gönderilmesine karar verilmiştir. Reşadiye’de 1910 baharında inşaat başlamıştır. Bazı yangınzedeler buraya yerleşmek istemedikleri için evlerini yine Çağa’ya yapmayı tercih etmiştir. Taşra yönetimi her ne kadar tedbirler alsa da buna engel olamamıştır. Böylece Çağalıların bir kısmı eski kasabalarında kalırken diğer kısmı Reşadiye’ye yerleşmiştir.
TRABZON ŞEHRİNDE NÜFUSUN GELİŞİMİ VE MEKÂNSAL DAĞILIŞI
Authors: SİYAVUŞ Ahmet Emrah , BELGE Rauf
Published: November 2022

Belirli bir mekân ve zaman dilimindeki insan sayısını ifade eden nüfus, şehirlerin mekânsal gelişimini doğrudan etkileyen bir dinamizmdir. Şehirlerde nüfusun artmasına bağlı olarak konut ihtiyacı artmakta, bu da şehirlerin yatay ve dikey yönde büyümesini hızlandırmaktadır. Şehirleşme olarak bilinen bu süreçte nüfusun zamansal ve mekânsal değişiminin bilinmesi büyük önem arz eder. Bir şehrin nüfusu incelenirken, zaman içerisindeki gelişimi ve değişimi, mekânsal dağılışı ve şehirleşme üzerindeki etkileri ele alınır. Bu bağlamda, bu çalışmada Karadeniz Bölgesinin Doğu Karadeniz Bölümü’nde yer alan Trabzon şehrinde nüfusun zamansal ve mekânsal değişimi ele alınmıştır. Mahallelere göre nüfusun dağılış ve yoğunluğu görsel olarak ifade edilmiştir. Trabzon nüfusu, Cumhuriyet öncesi ve sonrası olmak üzere iki ana başlık altında incelenmiştir. Şehrin Cumhuriyet’ten önceki nüfusu konuyla ilgili yazılmış kaynaklardan elde edilmiş; Cumhuriyet sonrası nüfusu Türkiye İstatistik Kurumu’ndan (TÜİK) temin edilmiştir. Elde edilen veriler coğrafi bakış açısı ile analiz edilerek harita, tablo ve grafiklere dönüştürülmüş, nüfusun gelişimi ve mekânsal dağılışı ortaya konulmuştur.
Role of simple ultrasonography rules in preoperative prediction of malignancy of adnexal masses
Authors: Jindal Shaleen Kedarchand , Kulkarni Sayali
Published: November 2022

Ovarian cancers account to malignancy in pre-menopausal women and post-menopausal women to about 24% and 60% respectively. This makes screening of ovarian cancers and adnexal masses an important part in diagnosis and management of these patients, as they also majorly form a reason for infertility in reproductive age group other than morbidity and mortality in all women. The limited availability of literature on the screening modalities and their definite role in diagnosing malignancy makes it difficult for gynecologists to diagnose the malignancy preoperatively. Ultrasonographic evaluation is considered as one of reliable and accurate diagnostic tool for the diagnosis of the ovarian cancers, so this study on utility of USG rules can help in preoperative screening of malignancy, and prediction of Malignancy helps in planning the management which avoid repeat surgery and morbidity.

This study attempts to identify a method for early and accurate diagnosis to provide appropriate treatment for the said diagnosis.

An observational comparative study was done and all gynecological patients attending IPD at SAMC and PGI with adnexal masses were evaluated for adnexal masses based on history, clinical examination, USG findings and routine preoperative investigations. Her pre operative diagnosis was co-related with histopathological report. After proper data collection, data was organized and analyzed with the application of Pearson chi-square test and associations were studied among the ultrasound findings and the final histopathological finding using p-value.

Among the above said variables assessed by Pearson chi square test they were found to be significantly associated with each other having high p values. So we can predict the risk of malignancy early by using Simple Ultrasonographic Rules as a diagnostic tool and accordingly earlier diagnosis can be made possible by this, thereby preventing both morbidities and mortalities in patient presenting with adnexal masses.
High risk pregnancies and implications of color Doppler
Authors: Vangani Veena , Vangani Mahendra , Vangani Bhavya
Published: November 2022

The aim of this study is High risk pregnancies & implications of color Doppler. Total 100 were selected with purposive sampling technique, (50 cases) study group of high risk pregnancy taken into the study & compared with an equal number of women with normal pregnancy without complication.

In our study we found, maximum cases in age group of 24-34 i.e. 49% in group A whereas in group B 43% in more than 34 age group. 41% normal in group A whereas 27% in group B. C-section 79% in group a & 21% in group B. Emergency caesarean section was uncommon in subjects with normal Doppler USG than those of with abnormal Doppler USG and also from group B.

In high risk women like pre eclampsia, diabetes & IUGR. Color Doppler flow velocimetry done repeatedly can predict address foetal events with a great degree of accuracy. Results obtained in study where clinically & statistically significant. Every tertiary hospital should routinely make use of facility for the assessment of fetal wellbeing in high risk cases & ensure a better perinatal outcome.

Color Doppler can be used as most effective for fetal surveillance in high risk pregnancy cases. Most importantly it helps in guiding early intervention and outcome.
Fetomaternal outcomes of emergency obstetric hysterectomy in a tertiary care teaching hospital in eastern India: A prospective study
Authors: Ghosh Abantika , Mandal Suchita , Gharami Somasree , Show Pritilata
Published: November 2022

To evaluate frequency, indications, demographic characters and the fetomaternal outcomes of emergency obstetric hysterectomy in a tertiary care teaching hospital in Eastern India.

Prospective, unicentric study.

 Records of all cases undergoing emergency obstetric hysterectomy in the emergency operation theatre of department of obstetrics and  gynecology during the study period were analyzed as per required variables and data was processed to evaluate the results.

: A total 22 obstetric hysterectomies were carried out during the study period, 7 (31.81%) cases following vaginal delivery and 15 (68.18%) cases during or following caesaren section. The incidence of obstetric hysterectomy was 0.63 per thousand deliveries. The mean age of the subjects was 26.81 ± 1.11 years. Placenta accreta spectrum was the most frequent indication for obstetric hysterectomy (36.36%). Hypotension requiring the use of vasopressors (77.27%) was the commonest complication faced by the subjects. Mortality rate amongst the subjects was 9.09%. Fetal outcomes were varied. 68.18% of the newborns were healthy. The mortality rate among the newborns was 9.09%.
20 weeks pregnancy with COVID-19 infection during second wave of pandemic: A case report
Authors: Deshpande Juhi , Gupta Pulkit
Published: November 2022

Novel corona virus (SARS-COV-2) is a new strain of corona virus causing COVID-19, first identified in Wuhan City, China. It was declared as a pandemic by the WHO on 11 March 2020. Pregnancy alters the body’s immune system and response to viral infections, therefore, pregnant females are related with more severe symptoms as compared to general population. Not much studies and guidelines are clearly available for the management of pregnant females with COVID-19. We are presenting a case of 20 weeks pregnancy with COVID -19 POSITIVE and how we managed the patient, during the second, deadly wave of pandemic. We hope this case report would be helpful for the clinicians to deal with pregnant patients with COVID 19, keeping in mind two lives are at risk.
Bimodal approach for a case of cervical ectopic pregnancy
Authors: Kumari Moturi Veera Durga , Shanthi Nalli , Rajachander Niranjani
Published: November 2022

Ectopic pregnancy though rare can be a life threatening obstetric emergency without prompt diagnosis and treatment, can lead to significant mortality and morbidity. Incidence of Cervical ectopic pregnancy is <1%. The only viable option was hysterectomy in the past. However, at present various uterine conservative methods are available and can be life saving and drastically decreases the morbidity associated.

28yrs G3P1L1A1 at 12 weeks 6 days of gestation with previous LSCS with previous history of Dilation & Evacuation came with USG report showing cervical ectopic pregnancy. Managed initially with 2doses of systemic methotrexate, in view of persistent complaints of spotting pervaginum patient underwent endocervical curettage.

Early diagnosis and treatment of cervical ectopic pregnancy with combined approach can effectively reduce the chances of life threatening hemorrhage.
Anamoly scan: A mandatory screening tool
Authors: Maini Manvi , Maan Monika , Kathpalia Sukesh
Published: November 2022

: Congenital anomalies can be due to various reasons. Some of these can significantly affect the viability of the fetus, some may impair quality of life subsequent to delivery and some may not have any significant effect. It is necessary to determine presence of congenital anomalies in-utero for better maternal and neonatal outcomes.

: To determine presence of congenital anomalies in mothers visiting antenatal clinics by conducting a second trimester anomaly scan.

: The study evaluated 2000 mothers visiting antenatal care in D. Y Patil Medical College and Hospital in Pune. A second trimester anomaly scan was conducted between 18-20 weeks of gestation in all the patients.

: The rate of fetal anomalies noted were 0.8% (16/2000 cases). 13 congenital anomalies were incompatible for viability of the fetus and hence were terminated. 3 congenital anomalies were minor in nature and hence continuation of pregnancy was advised. 2 mothers who were unbooked during antenatal period, delivered anomalous babies and were as well included in the evaluation.

: A second trimester anomaly scan should be made mandatory to identify any malformation in the growing fetus as we still have an option to terminate the pregnancy and save the family from the future setback. Also, with the advent of fetal medicine we can identify and treat the fetus in utero which might reduce the future complications.
Role of orbital exenteration in management of rhino-orbito-cerebral mucormycosis (ROCM) - A prospective analytical study
Authors: Kumar Niranjan Karthik Senthil , Raman Malarvizhi , Alagappan Yogeswari
Published: November 2022

Mucormycosis is an uncommon, opportunistic fungal infection. The most crucial decision in the management of rhino-orbital mucormycosis is when to advise exenteration. This study aims at understanding the pattern of cases which progressed and had extensive involvement of the entire orbital cavity with mild intra cranial extension requiring exenteration as life salvage measure in the setting of epidemic of mucormycosis in a pandemic of COVID – 19. Patients suspected or diagnosed with invasive orbital mucormycosis visiting our hospital were admitted and included in the study. CT PNS with orbit were done for all patients and MRI brain with orbit were done in patients in whom intracranial spread and involvement of optic nerve were present. Patients were started on liposomal intravenous amphotericin B (5mg/kg/day) and intraorbital amphotericin B injection when indicated and closely monitored for clinical progression. All patients were taken up for FESS and if positive for mucormycosis on histopathological examination. In cases wherever exenteration was indicated, after confirming that there was no perception of light and obtaining informed consent with psychiatric counselling patient was taken up for orbital exenteration. Lid sparing exenteration was the method of choice. A total of 41 patients out of 696(5.89%) underwent exenteration out of which 21(51.2%) were right sided and 20(48.8%) were left sided. 12 patients (29.2%) of those who had undergone exenteration did not have a history of being tested positive/ been symptomatic for COVID 19. 1 patient (2.4%) was not diabetic. All patients (100%) had sinonasal involvement (Involvement of one or more paranasal sinuses) with involvement of orbital cavity to different degrees. 4 out of 41(9.75%) patients had deteriorated and required ICU care. 1 patient succumbed to death (2.4%) due to multiple comorbidities. On histopathological examination of exenteration specimen, 2(4.87%) patients turned out to be negative for mucormycosis. In 32(78.04%) of them the socket healed well while 5(12.1%) had slough who required 2 or more sittings of sloughectomy. As mucor is angio invasive rapidly progressive highly fatal infection close monitoring for invasion into structures like apex of orbit and intra cranial spread is essential for timely intervention and decision to perform exenteration. This is crucial for arrest of progress and life salvage.
To determine the role of Anterior segment optical coherence topography (AS-OCT) pre- operatively to detect pre-existing weakness of the posterior capsule in patient of posterior polar cataract (PPC) effecting outcomes during phacoemulsification
Authors: Kumar Santosh , Singh Dhanishankar , Singh Vinod Kumar , Saini Sanchita , Rana Jagriti , Singh Arti
Published: November 2022

To determine the role of anterior segment optical coherence topography (AS-OCT) pre- operatively to detect pre-existing weakness of the posterior capsule in patient of posterior polar cataract (PPC) effecting outcomes during phacoemulsification.

A prospective observational study was done in 26 eyes with clinically diagnosed PPC who underwent phacoemulsification between November 2018 to December 2019. AS-OCT was done preoperatively to detect pre existing dehiscence of posterior capsule in patient of PPC. The images obtained by AS-OCT were divided into either intact or dehiscent. Integrity of posterior capsule was also observed during operation by surgeon.

In 26 eyes, dehiscence of posterior capsule was detected in 4 eyes (15.4%) by AS-OCT pre operatively, of posterior capsule in 3 eyes (11.5%) and intact posterior capsule in 23 eyes (88.5%). Rupture of posterior capsule occurred in 4 eyes during phacoemulsification. 3 out of 4 eyes who had rupture, had dehiscence of posterior capsule that was noted by AS-OCT and also intraoperatively while 1 eye was detected to have intact posterior capsule. The sensitivity of AS-OCT was 75% for detecting posterior capsule dehiscence and specificity was 95.65%.

: AS-OCT can be used preoperatively to identify posterior polar cataract that are at risk of posterior capsule rupture. This provides preoperative information to surgeon and helps in proper counselling of patients about the prognosis.
A clinical study on causes of small pupil and its management in Small incision cataract surgery
Authors: Reshma Bibi Khuteja  Shaikh , Hosnr Aparna
Published: November 2022

To evaluate the causes of small pupil and its intra-operative complications in SICS.

A total of 50 patients presenting to OPD with Small pupil measured after maximal dilation using tropicamide (0.5%) with phenylephrine (1%) e/d administered 4 times at 15 minutes interval were enrolled in this study. Detailed clinical history, prior medication, presence of possible risk factors, underlying co-morbidities and history of trauma were noted for every case.

The results drawn from the study out of 50 patients, revealed that 14 cases were associated with Pseudo-exfoliation syndrome, 16 cases with posterior synechiae (11 were associated with chronic uveitis And 5 cases had history of Trauma), 12 cases were associated with DM, 2 patients had history of intraocular surgery, 1 patient was on Tab. Tamsulosin for treatment of BPH. The remaining 5 cases were atonic pupil in old age patients.

The current study discusses the causes of Small pupil and its intra-operative complications along with its management. It’s crucial for every cataract surgeon to cope with small pupil manifesting preoperatively and intra-operatively.
Visual problems among video display terminal (VDT) users
Authors: Chakravorty Shalaka , Damor Kamlesh Gendalbhai , Radadiya Heena , Sapre Ashwini
Published: November 2022

To evaluate ocular problems, major symptoms and their associations among Video Display Terminal users.

100 subjects as cases and 100 subjects as controls were taken. Cases worked on computer for minimum of two hours per day while persons using computers for less than two hours a day were considered for Control group.

The difference in positive fusional vergence, near point of convergence and amplitude of accommodation between two study groups was statistically significant. Dry eye was significant manifestation among cases. Three most commonly reported symptoms were Blurred vision (96 %), tired eyes (93 %) and Headache (86 %).

Most of VDT users has abnormalities associated with accommodation and vergence dysfunctions. Dry eye is a significant factor associated with use of VDTs causing ocular discomfort. Duration of VDT use is directly related to the severity of the symptoms due to VDT use.
Baby weight gain parameters as predictive factors for progression of retinopathy of prematurity
Authors: Radhakrishnan Natasha , Priya A Lekshmy , Pillai Gopal S , Remanan Vrinda K
Published: November 2022

To study whether postnatal weight gain pattern can be a predictor of severe ROP.

We conducted a prospective observational studyBirth weight and weight gain was recorded at 2 weeks,4 weeks and 6 weeks for all premature babies undergoing screening for ROP in our ROP clinic and NICU. The weight gain data was collected for those who developed any grade of ROP-these babies were followed up for spontaneous regression or given laser treatment for Type 1 ROP.Type 1 ROP which required treatment was termed as Severe ROP.The weight gain parameters analysed were absolute weight gain at 2,4 and 6 weeks and weight gain proportion

We included 94 babies were included in the study. Out of 94, in 73 babies spontaneous ROP regressed was noted and 21 developed severe ROP. Mean birth weight in treated babies and non-treated babies were 909.29 ± 210.88 grams and 1107 ± 375.00 grams respectively. Absolute weight at 2,4 and 6 weeks were significantly low in severe ROP. Weight gain proportion at completed 2,4,6 weeks of life showed that at 4 weeks it was significantly (p 0.025) low in severe ROP. Weight gain per week at 4 and 6 weeks was low in Type I ROP babies (P 0.006 and 0.016 respectively)

In conclusion, this study found that postnatal weight gain is a significant factor that can predict the progression of ROP and those babies having a lower weight gain proportion in first 6 weeks should be followed up very closely for ROP progression.
Living parasite in the eyelid
Authors: Kadir Syeed Mehbub Ul , Ahmed Sharmin , Haider Golam , Hossain Md. Ismail , Hossain Tanjila , Bhowmik Narayon Chandra
Published: November 2022

To report a rare case of living parasite in the eyelid.

This case report was done in a tertiary care eye hospital in Bangladesh. We evaluated the patient thoroughly. CT scan of the orbit and histopathology were helped to diagnose the case. Per operative video recording, preoperative and postoperative photograph was documented properly.

: A young boy presented with gradual swelling in the right upper eyelid. Clinically a firm mass was found in the right upper eyelid. CT Scan of the orbit revealed a cystic lesion in the eyelid. A live worm was extracted from the right upper eyelid.

Parasitic lesion may be occurred in the eyelid. Ophthalmologist should be aware of the atypical presentation of the eyelid.
Prevalence of cardiovascular diseases in kidney transplant recipients and its relationship with asymmetric dimethylarginine, fibroblast growth factor-23 and multiple inflammatory markers
Authors: Wołoszyk-Chojecka Paulina , Malgorzewicz Sylwia , Chamienia Andrzej , Puchalska-Reglińska Ewelina , Dębska-Ślizień Alicja
Published: November 2022

Introduction and aim: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, a marker of endothelial damage and progression of atherosclerosis. Research confirms the association of ADMA with an increased risk of cardiac complications and an increased risk of death, graft loss among kidney transplant recipients (KTRs). The aim of our study was to establish the significance of ADMA and FGF-23 as biomarkers of cardiovascular risk as well as predictors of graft failure and progression of chronic transplant kidney disease in comparison to CKD subjects. In addition, an analysis of the relationship between ADMA, FGF23 and cardiovascular diseases in CKD subjects and KTRs was performed. Material and methods: The study group included 132 KTRs. The control group consisted of age- and sex-adjusted 40 individuals with clinically stable CKD. ADMA, FGF-23, hs-CRP and IL-6 were measured by the enzyme-linked immunoassay method (ELISA). Parameters of body mass composition such as fat mass, FTI, lean tissue mass, LTI, body water and overhydration were assessed by multi-frequency bioimpedance analysis (BIA). Results: Cardiovascular diseases (CVDs) were present in 31.8% of KTRs. Independent variables related to nutritional status (SGA, s-albumin), according to multivariate regression, may have an impact on the prevalence of CVD in the kidney transplant recipients’ group. Our study findings suggested a correlation between ADMA and serum albumin (r=-0.41, p<0.05), oxLDL (r=-0.42, p<0.05) and overhydration (OH%, r=0.28, p<0.05). Moreover, administration of statins and/or angiotensin-converting-enzyme inhibitors was significantly related to a reduction of ADMA in KTRs. We have also identified a significant positive correlation between FGF-23 levels and inflammatory markers (hs-CRP, IL-6) and negative with overall index of renal function (eGFR-CKD EPI, eGFR-MDRD). Conclusion: Nutritional status, inflammation and endothelial dysfunction markers (ADMA, FGF-23) are considerably altered even in stable kidney transplant recipients.
Proficiency Test Training for Mandarin Learners in Surakarta
Authors: Putri Septi K Dani , Phanata Stephanie , Indah Setyo Rahayu Kristina , Prasetyo Adi Dian , Avenida Quinta , Nastiti Sandyaningrum Juairiah
Published: November 2022

Hanyu Shuiping Kaoshi (HSK) or the Chinese Language Proficiency Test is an international standardized test in Chinese language proficiency. It is used to assess non-native Chinese speakers’ ability in using the Chinese language in their daily, academic, and professional lives. The purpose of administering training activities for the HSK Mandarin competency test is to help Mandarin language learners know the importance and benefits of the Mandarin language proficiency test (HSK) and where the certificate is used as one of the requirements to continue to a higher education level. It is also used to assess Mandarin language proficiency when applying to better job opportunities. The participants of this research are the teachers and students of SMA Bina Widya Solo where their learning system is at the HSK 4 level. The results showed that the students and the teachers of SMA Bina Widya Solo are more open to perspectives about the benefits of the HSK competency test as an instrument of measuring language skills that are internationally certified.
Keywords: counseling, training, HSK, Mandarin language
Managing the 8 Wastes of Lean at a Higher Education Institution: An ISM-MICMAC Approach
Authors: Permata Sari Hartanti Lusia , Jaka Mulyana Ig. , Gunawan Ivan , . Herwinarso
Published: November 2022

A Higher Education Institution (HEI) is required to be more competitive in maintaining its sustainability. The large number of stakeholders of an HEI makes it difficult to be agile in the intense competition. One of the concepts that can be used to improve the agility of an HEI is the Lean philosophy. Lean philosophy focuses on eliminating waste in the process of creating value for stakeholders. Previous research has identified several wastes in the operational activities of an HEI. This study aimed to develop a series of actions to eliminate wastes that have been identified. Interpretive Structural Modelling (ISM) and Matrices Impacts cross-multiplication applique classmate (MICMAC) are employed to model the relationship between wastes based on their mutual influence. ISM forms a hierarchical structure of interrelationships between wastes. Meanwhile, MICMAC will classify wastes based on their level of influence in a cartesian diagram. These models will help to analyze the root cause of the problem so that effective waste elimination actions can be arranged.
Keywords: Higher Education Institution, Lean, Waste, MICMAC, Lean Philosophy
The Eco Office Approach to Achieving Enviromentally Friendly Offices
Authors: Oemar H. , Djamaludin D. , Septiani A.
Published: November 2022

The current level of environmental damage has become a global problem. Office buildings have many activities that require a lot of energy consumption, including water and electricity. They also produced a lot of waste which harms the environment. Overcoming this environmental problem requires cooperation from all elements of society, especially academics in universities who act as the scientific community. The Eco Campus/Eco-Office program is the solution that is applicable in overcoming problems in the campus’s environment. This study aims to develop a design for implementing the Eco-Office at the Faculty of Engineering, Universitas Islam Bandung (UNISBA). The method used is a descriptive qualitative method using observations, in-depth interviews, and documentation studies. The results of this study were in the form of alternative and technical strategies. These alternative strategies included policy documents, standard operating procedures (SOP) for Eco-Office, and the formation of a special team to handle the Eco Office and routine outreach at the Faculty of Engineering, UNISBA. The technical strategies based on the existing conditions were energy efficiency (water and electricity), waste management, reducing the usage of papers, and maintaining office sanitation.
Keywords: Environmental, eco-office, campus, standard operating procedures, technical strategies
Effectiveness of E-Audit Implementation in the Indonesian Audit Board
Authors: Purnamasari Pupung , Hartanto Rudy
Published: November 2022

This paper aimed to find the effectiveness of e-audit implementation in the Indonesian Audit board (BPK). This research was conducted on the auditors who have used e-audit when conducting financial audits. 225 auditors were given questionnaires in four BPK regional offices: namely Jakarta, West Java, Central Java, and East Java. The results show various levels of the effectiveness of e-audit implementation among the auditors from the 4 regional offices. The test results of the effectiveness show that the implementation of e-audit is quite effective in supporting state financial audits. The results show that there are different levels of the effectiveness of the e-audit implementation; this means there is a need to increase the socialization of the use and implementation of e-audit to support a state financial audit. Future research is expected to examine the factors that influence the difference of the effectiveness level of e –audit implementation in BPK. A broader examination of types of e-audit systems used by BPK will increase the general understanding of the research results.
Keywords: e-audit, effectiveness, Indonesian Audit Board
Production and characterization of a carotenoid-rich peach palm flour
Authors: Prado Jeniffer Moraes de , Passos Graciele Rodrigues de , Santos Tiago Bratilieri dos , Silva Cassio Nazareno Silva da , Lemes Ailton César , Batista Karla de Aleluia , Sora Gisele Teixeira de Souza , Polesi Luís Fernando , Paula Ladyslene Chrísthyns de
Published: November 2022

Neste trabalho foi produzida e caracterizada uma farinha de pupunheira enriquecida com carotenóides visando agregar valor ao fruto da pupunheira, uma fruta amazônica ainda negligenciada comercialmente. A produção da farinha de pupunha permite o melhor aproveitamento do fruto, bem como o fornecimento do produto à indústria durante todo o ano. Primeiramente, os parâmetros do processo de produção da farinha de pupunheira foram otimizados visando obter um produto final com alto teor de carotenóides. A otimização foi realizada variando a composição do fruto (com ou sem casca), o pré-tratamento (com ou sem cozimento) e a temperatura de secagem (50, 60 e 70 °C). De maneira geral, a presença de casca e o uso de temperaturas mais altas (70ºC) durante a secagem foi capaz de proporcionar uma maior retenção de carotenóides na farinha. No entanto, o pré-tratamento por cozimento reduziu o teor de carotenóides totais na farinha produzida. Assim, uma farinha obtida a partir de frutos com casca preservada, sem pré-tratamento e seca a 70 °C, apresentou maior retenção de carotenóides. Nessas condições, a farinha de pupunha produzida apresentou alto teor de carotenóides totais (160 ?g/g), fibra alimentar total (11,1%), vitamina C (18 mg/100 g), lipídios (13%) e carboidratos totais ( 72,04%). A farinha também apresentou alta acidez titulável (34,79 mg/100 g), baixo pH (3,99), índice de absorção de água de 3,12 g/ge índice de solubilidade em água de 7,98%. Além disso, os parâmetros instrumentais de cor L (67,4), a* (8,6) e b* (71,2) indicaram uma farinha mais escura e alaranjada. Resumindo,