bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal associations of household use of cleaning agents and asthma symptoms in women: the EGEA study
Authors: Pacheco Da Silva Emilie , Ngutuka Mélanie , Dumas Orianne , Orsi Laurent , Ait-hadad Wassila , Lemire Pierre , Quentin Joane , Pin Isabelle , Varraso Raphäelle , Siroux Valérie , Le Moual Nicole
Published: February 2023

Objective

To evaluate the associations between the evolution of household use of cleaning products with the asthma symptom score and its evolution over 8 years.

Methods

Our study is based on 509 women participating in the last two surveys of the Epidemiological study on the Genetics and Environment of Asthma (EGEA) study (EGEA2: 2003–2007 (44 years, 19% current smokers) and EGEA3: 2011–2013). We assessed an asthma symptom score and the use of household cleaning products through standardised questionnaires. We studied longitudinal associations of the evolution of weekly use of irritant or spayed cleaning products with (1) the asthma symptom score at EGEA3 and a stable symptom score between EGEA2-EGEA3 (negative binomial models) and (2) the incidence/evolution of asthma symptoms between EGEA2-EGEA3 (logistic/polytomous logistic regressions). Models accounted for familial dependence and were adjusted for age, smoking status, body mass index and occupational exposure to asthmagens.

Results

Persistent and increased (40% and 16%, respectively) weekly use of irritants or sprays were associated with a higher risk of asthma symptoms at EGEA3 (Mean Score Ratio (MSR)=1.51 (95% CI 1.06 to 2.14) and 1.33 (95% CI 0.85 to 2.08), respectively). A decreased use (19%) was associated with a lower risk of symptoms at EGEA3, compared with a persistent use (MSR=0.59 (95% CI 0.39 to 0.88)). We also observed an association between an increased use of sprays and the incidence of asthma symptoms (OR=2.30 (95% CI 1.08 to 4.91)), compared with no weekly use of irritants/sprays.

Conclusions

This longitudinal study, with repeated assessment of exposure and respiratory health, supports the hypothesis that a persistent or increased weekly use of sprayed cleaning products over time may have an adverse effect on the evolution of asthma symptoms.
Effects of different nutrient compensation treatments following forest fuel extraction on biomass of young Norway spruce (Picea abies (L.) Karst.)
Authors: Brandtberg P.-O. , Olsson Bengt A. , Wang Pei , Lundkvist Helene
Published: February 2023

Whole tree harvesting of forests may require compensation for losses of nutrients and alkalinity. The effects of three different practical ameliorative methods on spruce allometry, total biomass, and nutrient uptake were studied in an experiment in a 3-year-old Norway spruce ( Picea abies (L.) Karst.) stand in south-west Sweden. The treatments were one application of the fine fraction of logging residues, one application of granulated wood ash, two applications of an N-free vitality fertiliser, and untreated control. Analysis of covariance showed that spruce needle and stem allometry depended on treatment. Spruce fine root allometry was very variable, showing no discernible effect of treatment. Fine root distribution was shallower in treatments with higher graminoid biomass (vitality and wood ash). Vitality treatment increased average concentrations of Ca, Mg, and Zn in spruce total biomass. Ash treatment only increased the Zn concentration. The average N concentration was similar between treatments. Spruce total biomass per unit area was inversely correlated with graminoid biomass. Measurements of N uptake in spruce and graminoid biomass indicated that there was competition for N between spruce and graminoids. Thus, the effect of nutrient compensation on competition needs to be considered when predicting the effect on the growth of the target species.
Light quark decays of doubly heavy baryons in light front approach
Authors: Liu Hang , Xing Zhi-Peng , Yang Chang
Published: February 2023

We explore the semileptonic and nonleptonic decays of doubly heavy baryons $$(\Omega _{cc}^{(*)+},\Omega _{bb}^{(*)0},\Omega _{bc}^{(*)-},\Omega _{bc}^{\prime 0})$$

(

Ω

cc

(

∗
)
+

,

Ω

bb

(

∗
)
0

,

Ω

bc

(

∗
)
-

,

Ω

bc

′
0

)

induced by the $$s\rightarrow u$$

s
→
u

transition. Hadronic form factors are parametrized by transition matrix elements and are calculated in the light front quark model. With the form factors, we make use of helicity amplitudes and analyze semileptonic and nonleptonic decay modes of doubly heavy baryons. Benchmark results for partial decay widths, branching fractions, forward–backward asymmetries and other phenomenological observables are derived. We find that typical branching fractions for semileptonic decays into $$\ell \bar{\nu }$$

ℓ

ν

¯

are at the order $$10^{-7}-10^{-8}$$

10

-
7

-

10

-
8

and the ones for nonleptonic decays are at the order $$10^{-5}$$

10

-
5

, which are likely detectable such as in LHCb experiment. With the potential data accumulated in future, our results may help to shape our understanding of the decay mechanism in the presence of two heavy quarks.
Effect of electromagnetic permeability on transition temperature of superconductivity
Authors: Bagheri-Mohagheghi M. M. , Pourhassan B. , Adelifard M. , Shokooh-Saremi M. , Upadhyay S.
Published: February 2023

The description of superconductivity at high-temperature is a problem that has recently been addressed. Transition temperature of superconductivity, [Formula: see text], depends on the lattice structure type, size and room pressure. In super-lattices and low-dimensional layered nanostructures, [Formula: see text] is increased by increasing the complexity of the structure and internal pressures in solid lattice. In this paper, we investigate the relation between physical parameters ([Formula: see text]) of matter and superconductivity properties as well as transition temperature ([Formula: see text]), and explain the superconductivity at high-temperature. In this study, a semi-classical electromagnetic description along with vortex topologic theory and quantum dynamic models with experimental data is considered to justify the relation between superconductivity phenomena and magnetic monopole properties. We find that the electromagnetic energy of magnetic monopole is in agreement with vortex energy in topological theory and it can get close to thermal energy at high-temperature. These models suggest that the superconductivity is related to the mobile monopole or vortices. We show that the electrical permittivity ([Formula: see text]) and magnetic permeability ([Formula: see text]) of matter have a key role in the superconductive properties.
Oxidative defluorination reactivity of μ-nitrido diiron tetraphenylporphyrin complex
Authors: Colomban Cédric , Kudrik Evgeny V. , Afanasiev Pavel , Sorokin Alexander B.
Published: February 2023

Transformation of organofluorine compounds by oxidation pathways is rare in chemistry and biology since C-F bonds formed by the most electronegative element should react with electron-deficient oxidizing species. Recently, we have shown that [Formula: see text]-nitrido diiron phthalocyanine complexes efficiently catalyze oxidative defluorination of poly- and perfluoroaromatics by H2O2. Herein, we studied their more biologically relevant porphyrin counterpart, [Formula: see text]-nitrido diiron(III,IV) tetraphenylporphyrin complex (TPP)Fe[Formula: see text]N)Fe[Formula: see text](TPP) in stoichiometric and catalytic reactions with a series of fluorinated aromatic compounds under oxidation conditions. The addition of hexafluorobenzene to (TPP)Fe[Formula: see text]N)Fe[Formula: see text](TPP) in the presence of [Formula: see text]-butylhydroperoxide led to the formation of high-valent [Formula: see text]-nitrido diiron(IV,IV) porphyrin cation radical complex [TPP)Fe[Formula: see text] -N)Fe[Formula: see text](TPP[Formula: see text]]F2. This complex was isolated and its structural and electronic properties were investigated by spectroscopic methods (EXAFS, XANES, EPR, UV-vis). Replacement of [Formula: see text]BuOOH with H2O2oxidant resulted in the catalytic defluorination of selected heavily fluorinated aromatic compounds with high conversions (25–84%), TON (1768–3535), and defluorination degrees (71–84%). The scope of oxidative defluorination with (TPP)Fe[Formula: see text]N)Fe[Formula: see text](TPP) was extended to perfluorinated olefins exemplified by perfluoroallylbenzene. The perfluorinated double bond was more reactive compared with perfluorinated aromatic moiety providing C6F5CF2COOH and C6F5COOH products. The properties of [Formula: see text]-nitrido diiron tetraphenylporphyrin in homogeneous and heterogeneous catalytic defluorination were compared with those of its phthalocyanine counterpart.
Actuation of shape memory poly(vinyl alcohol) and graphene oxide film in water
Authors: Wang Changchun , Wu Zi-Qi , Huang Yu-An , Zhang Zewu
Published: February 2023

The PVA/GO film prepared by vacuum-assisted self-assembly exhibits quick thermo-/water- responsive shape memory effect. The anisotropic lamellar structure of GO sheets and plenty of chemical groups containing oxygen in the PVA/GO film facilitate rapid recovery in water. The lamellar structure of GO sheets improves the recovery stress of composite and results in a 16-fold increase in Young’s modulus. PVA molecular chain slides along the direction of the laminated GO sheets, consistent with the extension direction, ensuring that the composite film maintains a large fracture strain. The straight film is programmed into a spiral shape by the plasticization of water on PVA instead of ordinary heating and the spiral film can drive a weight 160 times its own weight to rotate in water at room temperature (about 25[Formula: see text]C).
A Correctness and Incorrectness Program Logic
Authors: Bruni Roberto , Giacobazzi Roberto , Gori Roberta , Ranzato Francesco
Published: February 2023

Abstract interpretation is a well-known and extensively used method to extract over-approximate program invariants by a sound program analysis algorithm. Soundness means that no program errors are lost and it is, in principle, guaranteed by construction. Completeness means that the abstract interpreter reports no false alarms for all possible inputs, but this is extremely rare because it needs a very precise analysis. We introduce a weaker notion of completeness, called
local completeness
, which requires that no false alarms are produced only relatively to some fixed program inputs. Based on this idea, we introduce a program logic, called Local Completeness Logic for an abstract domain
A
, for proving both the correctness and incorrectness of program specifications. Our proof system, which is parameterized by an abstract domain
A
, combines over- and under-approximating reasoning. In a provable triple ⊦

A

[
p
] 𝖼 [
q
], 𝖼 is a program,
q
is an under-approximation of the strongest post-condition of 𝖼 on input
p
such that their abstractions in
A
coincide. This means that
q
is never too coarse, namely, under some mild assumptions,

the abstract interpretation of 𝖼 does not yield false alarms for the input
p
iff
q
has no alarm

. Therefore, proving ⊦

A

[
p
] 𝖼 [
q
] not only ensures that all the alarms raised in
q
are true ones, but also that if
q
does not raise alarms, then 𝖼 is correct. We also prove that if
A
is the straightforward abstraction making all program properties equivalent, then our program logic coincides with O’Hearn’s incorrectness logic, while for any other abstraction, contrary to the case of incorrectness logic, our logic can also establish program correctness.
A Beginner's Tutorial on Strategy Complexity in Stochastic Games
Authors: Shirmohammadi Mahsa
Published: February 2023

This article is a tutorial introduction to stochastic games, first introduced by Shapley in 1953. The presentation is based around several classical examples of such games, and focusses on the question of strategy complexity in terms of parameters such as the cardinality of the state space, branching factor of the transition function, and whether the game is concurrent or turn-based. Our goal is to give a practical introduction to stochastic games, the notion of values and strategies, and the memory requirements of optimal and ε-optimal strategies in different games.
Space-Time Resource Integrated Optimization Method for Time-of-Day Division at Intersection Based on Multidimensional Traffic Flows
Authors: Liang Zijun , Zhan Xuejuan , Kong Wei , Xiao Yun
Published: February 2023

Based on the change trends of traffic flow in different controlled directions at an intersection, the space-time resource integrated optimization method for TOD (time-of-day) division based on multidimensional traffic-flow data is proposed in this paper. By analyzing the traffic-flow data of 8, 4, 2, and 1 dimensions commonly used at the intersection, the dynamic Fisher algorithm is used to complete the time segment division of the traffic-flow sequence of different dimensions. On this basis, the preliminary TOD division is completed, and the phase timing and lane-use assignment corresponding to the preliminary time periods are optimized. Then, the adjacent time periods are merged and tested to complete the final result of the TOD division. In order to verify the effectiveness of the proposed method, the schemes based on traffic-flow data of different dimensions are carried out by using the data at an actual intersection in Wuhu City, and the total and average vehicle delays of different schemes throughout the day are evaluated by VISSIM. The results show that the more dimensions of traffic flow data are adopted, the more refined the TOD division scheme is, and the less the total delay and average delay at intersections throughout the day are. In particular, the TOD division scheme after further optimizing the lane-use assignment can further reduce the total and average vehicle delay throughout the day. It shows that the method using multidimensional traffic-flow data at an intersection to carry out the integrated optimization of TOD division, lane-use assignment, and phase timing has good applicability.
Study on Braking Energy Recovery Control Strategy for Four-Axle Battery Electric Heavy-Duty Trucks
Authors: Li Xuebo , Ma Jian , Zhao Xuan , Wang Lu
Published: February 2023

Regenerative braking can extend the driving range and reduce PM emissions from abrasion for battery electric heavy-duty trucks (BETs). The composite braking control strategy including torque distribution and dynamic coordinated control for the four-axle BET equipped with the electromechanical braking system is studied. A segmented torque distribution strategy is proposed to maximize energy recovery while ensuring braking stability. The simulation results reveal that the strategy shows better comprehensive braking performance than the two benchmark strategies, and the energy recovery rate in different load states under CHTC-D is above 40%. The proposed coordinated control strategy takes advantage of regenerative braking’s rapid response and precise control to compensate for torque deviations caused by the hysteresis of friction braking. For two common braking mode transition conditions, regenerative braking torque correction and advance of the mode switching timing are adopted to enable the motor to obtain the torque compensation ability. This method leads to a slight loss of braking energy, and the maximum torque deviation during the mode switching process is suppressed to less than 1.4 kN·m, and the jerk and braking distance is reduced accordingly, which is of great importance in improving driving comfort and braking safety.
Topical Administration of Crisaborole in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta‐Analysis
Authors: He Yufei , Liu Jia , Wang Yulian , Kuai Wenhao , Liu Ran , Wu Jianhua
Published: February 2023

Background. Crisaborole has been considered a promising alternative for topical treatment of atopic dermatitis (AD), mainly supported by AD‐301 and AD‐302. However, critical insights into these two studies have previously been proposed. Objective. To make a comprehensive assessment of the application of crisaborole in mild to moderate AD. Methods. A systematic review and meta‐analysis were conducted, in which only randomized controlled trials comparing the application of crisaborole twice daily to vehicle or other active treatment in patients with mild to moderate AD were included. The selection of outcomes was based on the recommendation of the HOME initiative. Patient‐reported symptoms, clinician‐reported signs, health‐related quality of life, and the safety of crisaborole were all assessed using appropriate measurement instruments. Results. Eight RCTs with 2266 patients were included in the pooled analysis. Compared to those treated with vehicle, patients on crisaborole experienced a greater improvement in NRS (MD −0.70; 95% CI −0.94 to −0.47), POEM (MD −3.50; 95% CI −4.34 to −2.66), EASI (MD −14.49%; 95% CI −18.24% to −10.73%), ISGA (RR 1.45; 95% CI 1.28 to 1.63), DLQI (MD −1.54; 95% CI −2.17 to −0.92), and DFI (MD −1.16; 95% CI −1.72 to −0.59) during the 4‐week treatment. More patients achieved EASI 75 (RR 1.71; 95% CI 1.43 to 2.04) with crisaborole administration. There was no significant difference between two interventions in the incidence of AEs (RR 1.12; 95% CI 0.98 to 1.29), SAEs (RR 1.89; 95% CI 0.47 to 7.60), or AE‐related withdrawal (RR 0.87; 95% CI 0.47 to 1.60). One RCT also made comparison between crisaborole and pimecrolimus, suggesting that no significant difference was detected in the improvement of EASI or NRS at most time points. Conclusion. High‐quality evidence was provided to demonstrate that the short‐term application of crisaborole is safe and efficacious for the treatment of mild to moderate AD. The practical efficacy of crisaborole is similar to that of pimecrolimus.
Effects of Tributyrin Supplementation on Growth Performance, Intestinal Digestive Enzyme Activity, Antioxidant Capacity, and Inflammation-Related Gene Expression of Large Yellow Croaker (Larimichthys crocea) Fed with a High Level of Clostridium autoethanogenum Protein
Authors: Wang Xiuneng , Wan Min , Wang Zhen , Zhang Haitao , Zhu Si , Cao Xiufei , Xu Ning , Zheng Jichang , Bu Xianyong , Xu Wei , Mai Kangsen , Ai Qinghui
Published: February 2023

An 8-week growth experiment was conducted to investigate effects of tributyrin (TB) supplementation on growth performance, intestinal digestive enzyme activity, antioxidant capacity, and inflammation-related gene expression of juvenile large yellow croaker (Larimichthys crocea) (initial weight of

12.90
±
0.02
 
g

) fed diets with high level of Clostridium autoethanogenum protein (CAP). In the negative control diet, 40% fish meal was used as the major source of protein (named as FM), while 45% fish meal protein of FM was substituted with CAP (named as FC) to form a positive control diet. Based on the FC diet, grade levels of 0.05%, 0.1%, 0.2%, 0.4%, and 0.8% tributyrin were added to formulate other five experimental diets. Results showed that fish fed diets with high levels of CAP significantly decreased the weight gain rate (WGR) and specific growth rate (SGR) compared with fish fed the FM diet (

P
<
0.05

). WGR and SGR were significantly higher than in fish fed diets with 0.05% and 0.1% tributyrin that fed the FC diet (

P
<
0.05

). Supplementation of 0.1% tributyrin significantly elevated fish intestinal lipase and protease activities compared to FM and FC diets (

P
<
0.05

). Meanwhile, compared to fish fed the FC diet, fish fed diets with 0.05% and 0.1% tributyrin showed remarkably higher intestinal total antioxidant capacity (T-AOC). Malondialdehyde (MDA) content in the intestine of fish fed diets with 0.05%-0.4% tributyrin was remarkably lower than those in the fish fed the FC diet (

P
<
0.05

). The mRNA expressions of tumor necrosis factor α (tnfα), interleukin-1β (il-1β), interleukin-6 (il-6), and interferon γ (ifnγ) were significantly downregulated in fish fed diets with 0.05%-0.2% tributyrin, and the mRNA expression of il-10 was significantly upregulated in fish fed the 0.2% tributyrin diet (

P
<
0.05

). In regard to antioxidant genes, as the supplementation of tributyrin increased from 0.05% to 0.8%, the mRNA expression of nuclear factor erythroid 2-related factor 2 (nrf2) demonstrated a trend of first rising and then decreasing. However, the mRNA expression of Kelch-like ECH-associated protein 1 (keap1) was remarkably lower in fish fed the FC diet than that fed diets with tributyrin supplementation (

P
<
0.05

). Overall, fish fed tributyrin supplementation diets can ameliorate the negative effects induced by high proportion of CAP in diets, with an appropriate supplementation of 0.1%.
Electronic, Thermal, and Thermoelectric Transport Properties of ReSe2 and Re2Te5
Authors: Bang Joonho , Park Okmin , Kim Hyun-Sik , Hwang Seung-Mee , Lee Se Woong , Park Sang Jeoung , Kim Sang-il
Published: February 2023

Re-based chalcogenides have been studied in various fields such as strain engineering, photodetection, spintronics, and electromechanics, as well as in piezoelectric and photonic devices. In this study, the electrical, thermal, and thermoelectric transport properties of two representative Re-based chalcogenides, ReSe2 and Re2Te5, are investigated systematically. Furthermore, their electronic band dispersions are calculated using density functional theory and compared with the phenomenological data. The maximum power factor values for the ReSe2 and Re2Te5 were measured 0.0066 and 0.11 mW/mK2 at 880 K, respectively. Thermal conductivity of layered ReSe2 at room temperature was between 1.93 and 8.73 W/mK according to the measuring direction. For Re2Te5 with a complex orthorhombic crystal structure, the thermal conductivity was quite low in the range between 0.62 and 1.23 W/mK at room temperature. As a result, the maximum

z
T

values of ReSe2 were quite low as 0.0016 at 880 K due to very low power factor and high thermal conductivity. Meanwhile, the relatively high

z
T

of 0.145 in Re2Te5 is obtained at 880 K, which is originated from the acceptable power factor value and the low thermal conductivity.
Ultrasonic Extraction of Phenolic Compounds from Eggplant Peel and Formulation of Eggplant Peel Extract-Enriched Ice-Cream
Authors: Kainat Farwa , Ali Moazzam , Akbar Ali , Masih Rashid , Mehnaz Samina , Sadiq Muhammad Bilal
Published: February 2023

In this study, ultrasound-assisted extraction (UAE) was used for the extraction of bioactive compounds from eggplant peels (EPP) and conditions were optimized by using response surface methodology (RSM). Methanol concentrations (60%, 70%, and 80%), time (30 min, 45 min, and 60 min), and temperature (30°C, 45°C, and 60°C) were selected as independent extraction parameters, whereas total anthocyanin content (TAC), DPPH inhibition, and total phenolic content (TPC) were response variables. The optimal extraction was at 45°C for 45 min of extraction time with 70% solvent which corresponded to TAC, TPC, and DPPH inhibition values of 7.94 mg/g, 7.03 mg GAE/g, and 94.8%, respectively. The optimized EPP extract was chemically characterized by a Fourier-transform infrared spectrometer (FTIR), high-performance liquid chromatography (HPLC), and a gas chromatography mass spectrometer (GCMS). The optimized extract was further evaluated for antioxidant and anticancer potential. For antioxidant and anticancer potential, the corresponding IC50 values of the EPP extract were 243.2 μg/ml and 1.52–1.99 mg/ml, respectively. Furthermore, the EPP extract significantly inhibited the migratory ability of cancer cells in a dose-dependent manner. Major components identified in the EPP extract were chlorogenic acid (261.76 mg/kg), benzoic acid (184.41 mg/kg), syringic acid (78.48 mg/kg), p-coumaric acid (49.59 mg/kg), cinnamic acid (32.17 mg/kg), quercetin (5.24 mg/kg), sinapic acid (5.14 mg/kg), and gallic acid (4.34 mg/kg). The EPP extract-enriched ice-cream showed high antioxidant potential and consumer acceptability than the blank ice-cream formulation. The EPP extract, due to its antioxidant and anticancer potential, can be used in the formulation of functional food products.
Review of Refractive Index-Matching Techniques of Polymethyl Methacrylate in Flow Field Visualization Experiments
Authors: Fan Dajun , Li Rongjie , He Minghan , Li Xianwen , Li Jinyang , Wen Jun , Hu Yongping , Li Yanan , Li Yue , Gu Long , Li Zhifeng
Published: February 2023

The development of modern computational fluid dynamics (CFD) technology provides many preliminary references for experimental design. In addition, the CFD calculation results verified by experiments can display enormous microdata in areas that are difficult to measure through experiments, as an extension. This can make measurements more reasonable and effective, shorten measurement times, and save manpower and capital significantly. Therefore, it is vital to verify the accuracy of CFD calculation results, especially in cases of complex structures and multiphase flows. The results of model tests can be utilized in a prototype experiment by properly designing a test section and selecting a working fluid if the Reynolds similarity criterion is met. Optical measurement technology is a noninvasive measurement method, and the impact on the flow field can be almost negligible. It is advised to use transparent materials and prepare a refractive index-matching (RIM) fluid to obtain a good optical path. Polymethyl methacrylate (PMMA) is widely used in flow field visualization experiments because of its good light transmission and mechanical strength. This review is aimed at introducing the current status of different flow field measurement techniques; moreover, it is intended to help the readers to become more familiar with the principles of RIM, the characteristics, applications, and usage suggestions of various RIM fluid schemes of PMMA, providing references for researchers in the design, preparation, and conducting stages of flow field visualization measurement experiments. This review is divided into five sections. In the introduction section, Chapter 1, relevant research developments and related results of flow field measurements are presented, followed by the innovations and benefits of this paper. In Chapter 2, the flow field visualization measurements are presented and a derivation is shown. In Chapter 3, some RIM fluid schemes of PMMA and their applications are given, which are very valuable for peers. In Chapter 4, the measurement and analysis of some physical properties are described. In the RIM process, it is necessary to focus on the RI, density, dynamic viscosity, compatibility, stability, safety, and cost of RIM fluids. These factors greatly impact the accuracy of experimental results, experimental progress, and safety of the experimenters. Based on the analysis and our practical experience, some suggestions are given for preparing and using RIM fluids. In the conclusion section, Chapter 5, the results and practical implications of this paper are summarized.
Effect of In-Cylinder Low-Pressure Direct Injection Strategy on the Atomization and Combustion Process of a Small-Scaled Gasoline Wankel Rotary Engine
Authors: Li Yuan , Liu Jinxiang , Huang Weiqing , Wang Nana
Published: February 2023

To solve the problem of poor atomization and combustion in a small-scaled gasoline Wankel rotary engine (WRE) with low-pressure port injection mode, the numerical simulation was used to optimize the injection strategy. Firstly, the effects of in-cylinder temperature and pressure on gasoline atomization characteristics were studied, and the optimal injection timing was determined. Based on this, the influence of injection position, injection angle, and installation direction on the atomization, fuel-air mixing, and combustion processes of low-pressure direct injection (DI) small-scaled gasoline WRE was investigated. The results show that the injection angle is a key factor in determining the gasoline atomization characteristics. Injecting along the direction of rotor rotation causes the impingement between fuel bundle and combustion chamber pocket, resulting in the smaller Sauter mean diameter (SMD) and liquid penetration length (LPL). The installation direction of nozzle plays an important role in the airflow movement. When the nozzle is vertical-installed, the airflow repeatedly crosses to form multiple eddies, making the fuel to move more easily towards the front of combustion chamber. When the nozzle is parallel-installed at the lower edge of the installing zone and injecting along the direction of rotor rotation, the peak in-cylinder pressure is the largest and increased by 21% compared to the original port injection. By this injection strategy, the problem of incomplete combustion for the studied small-scaled gasoline WRE could be almost completely solved.
Role of Laryngopharyngeal Reflux Changes in Children with Adenoid Hypertrophy: A Randomized Controlled Prospective Study
Authors: Zhou Yu , Ma Ruixia , Luo Jiangbo , Wang Zhikai , Yang Pei
Published: February 2023

Objectives. This prospective randomized controlled analysis aimed to assess the changes in laryngopharyngeal reflux (LPR) in children with adenoid hypertrophy (AH). Study design: a prospective, randomized, and controlled analysis. Methods. The reflux symptom index (RSI) and the reflux finding score (RFS) scores were used to evaluate the laryngopharyngeal reflux changes in children diagnosed with adenoid hypertrophy. The pepsin concentration in salivary samples was examined, and the positive pepsin was used to assess the sensitivity and specificity of RSI, RFS, and RSI combined with RFS in forecasting LPR. Results. In 43 children with AH, the sensitivity of the RSI and RFS scale (used alone or in combination) in diagnosing pharyngeal reflux in children with adenoid hypertrophy was lower. Pepsin expression was identified in 43 items of salivary samples, with a total positive rate of 69.77%, most of which were optimistic. The expression level of pepsin was positively correlated with the grade of adenoid hypertrophy (r = 0.576, P < 0.01). Based on the positive rate of pepsin, we found that the sensitivity and specificity of RSI and RFS were 5.77%, 35.03%, and 91.74%, 55.89%. Moreover, there was a noticeable distinction in the number of acid reflux episodes between the LPR‐positive and LPR‐negative groups. Conclusion. There is a special connection between LPR change and children’s AH. LPR exerts a crucial role in the progression of children’s AH. Because of the low sensitivity of RSI and RFS, it is not suitable for LPR children to choose AH.
Development of a Phase Change Backfill Material with High Heat Capacity and High Thermal Conductivity Used for Ground Source Heat Pumps
Authors: Chen Yixia , Luo Tingting , Pei Peng , Ran Yujin , Tang Long
Published: February 2023

To solve the problems of phase change materials (PCM) including low thermal conductivity and easy washout and loss after liquefaction in current studies on borehole backfill materials, capric acid-lauric acid/expanded graphite (CA-LA/EG) PCM admixture with high thermal conductivity and high heat capacity was developed by using expanded graphite as the carrier. The PCM admixture is mixed with original sands (drilling debris) to make phase change backfill materials (PCBM). When the PCM backfilling is applied, the key issue is to dissipate the large amount of heat stored as latent heat in boreholes to the surrounding formation in time; otherwise, serious heat accumulation would be induced. Numerical simulation of application of the PCBM in multiple intermittent operation cycles was conducted when the admixture percentages and thermal conductivities are different. The result shows that compared with conventional low-conductivity PCM admixtures and ordinary backfill sands such as drilling debris, the CA-LA/EG admixture can mitigate the temperature fluctuation in borehole and improve its heat exchange rate. The heat exchange rate was increased by 11.6% when 30% of CA-LA/EG admixture was added. However, the improvement declined as the number of operation cycle increased, so the intermittent operation mode is suggested to match the PCBM application since the heat in borehole should be dissipated in time to reserve storage capacity in the next operation cycle and continuously utilize the high heat capacity of the PCM.
Long-Term Outcomes of High-Dose Conbercept Treatment for Myopic Choroidal Neovascularization and Idiopathic Choroidal Neovascularization
Authors: Zhu Wei , Hao Yanlei , Yuan Zhongfang , Huang Chunmei , Liu Jiehui , Ma Yan
Published: February 2023

Introduction: The aim of the study was to report 2-year outcomes of intravitreal injection of high-dose conbercept (1 mg 2 + PRN scheme) for subjects with myopic choroidal neovascularization (mCNV) and idiopathic choroidal neovascularization (iCNV) by optical coherence tomography angiography follow-up. Methods: A total of 38 subjects (38 eyes) were enrolled in this retrospective study, which were divided into group A (mCNV, 20 subjects, 20 eyes) and group B (iCNV, 18 subjects, 18 eyes). All subjects received 1.0 mg of conbercept intravitreally at diagnosis and again 35 days later. Additional conbercept injection was administered upon findings of decreased best-corrected visual acuity (BCVA); metamorphosis aggravation, macular hemorrhage, or edema; increased central retinal thickness (CRT); or leakage observed by fluorescein angiography. The BCVA, CRT, and CNV areas of the two groups were evaluated at baseline and at 1, 2, 4, 6, 12, and 24 months after surgery. Results: The BCVA of group A improved from 0.31 ± 0.16 logMAR at baseline to 0.12 ± 0.03 logMAR at the final follow-up (p < 0.001), while in group B the corresponding improvement was from 0.33 ± 0.16 logMAR at baseline to 0.12 ± 0.03 logMAR at the final follow-up (p < 0.001). Visual acuity improved in 17 subjects in group A and 15 in group B, while it remained stable in 3 subjects in each of groups A and B. CRT decreased from 311.83 ± 30.95 μm in group A and 351.17 ± 37.09 μm in group B preoperation to 229.56 ± 5.75 μm and 227.67 ± 4.98 μm at 24-month follow-up, respectively (p < 0.001 in groups A and B). Metamorphopsia was improved in subjects in groups A and B. CNV had disappeared in the two groups at the last postoperative visit. The BCVA, CRT, and CNV areas showed no statistical differences between the two groups at 6-, 12-, and 24-month follow-up (p > 0.05). Conclusion: Intravitreal injection of conbercept (1 mg 2 + PRN scheme) is effective for treating patients with mCNV or iCNV, which can improve and stabilize vision as well as dramatically alleviate metamorphopsia.
Sociedade do cansaço e ideário neoliberal: a abordagem do tema burnout em mídia de negócios no Brasil
Authors: Farias Luiz Alberto de , Künsch Dimas A. , Aiello Thaís Regina
Published: February 2023

O presente artigo se debruça sobre o espraiamento da ideologia neoliberal na sociedade contemporânea e seus impactos no mundo do trabalho, vislumbrando igualmente suas imbricações com a comunicação e a cultura do management. O objetivo é compreender como o ideário neoliberal tem se entranhado em diferentes âmbitos da vida cotidiana, chegando a constituir o que o filósofo sul-coreano Byung-Chul Han cunhou como “sociedade do cansaço”. Nela, a produtividade é superlativa e causa adoecimento, a exemplo da Síndrome de Burnout. O objeto de estudo da pesquisa diz respeito ao portal Exame, principal mídia de negócios do Brasil, a partir de um recorte que considera tanto o conteúdo editorial sobre a Síndrome do Burnout quanto a iniciativa de marketing subjacente a esse tema. A partir de conteúdos selecionados, foram realizadas análises de modo a depreender a construção de opiniões e geração de sentidos que reforçam o ideário neoliberal e os pilares da sociedade da produtividade, outra nomenclatura utilizada por Han para identificar a chamada sociedade do cansaço.
Atos de improbidade: como a lei nº 14.230/2021 modificou os tipos infrativos da LIA?
Authors: Marrara Thiago
Published: February 2023

Este artigo se propõe a analisar as alterações promovidas pela Lei nº 14.230/2021 na Lei de Improbidade Administrativa (LIA) no âmbito dos atos de improbidade administrativa. A Lei de 2021 promoveu modificações significativas nos art. 9º, 10 e 11 da LIA, principalmente quanto à descrição dos tipos infrativos, com o intuito, em especial, de limitar a improbidade por violação de princípios. Tais mudanças são decorrentes de um movimento de reação à banalização ou vulgarização do microssistema da improbidade, que passou, no passado recente, a ser manejado frequentemente contra simples falhas ou erros no exercício das tarefas públicas, afastando-se de sua finalidade essencial de combater os graves atos de desonestidade na gestão pública. Nesse sentido, o presente artigo se propõe a analisar as alterações promovidas nesta tríplice categorização dos atos infrativos de improbidade, além de propor uma reflexão sobre os impactos de cada uma delas para o microssistema de responsabilidade em análise.
Inéditos de Basílio da Gama
Authors: Dias Maurício Santana , Mariano Alexandra de Brito
Published: February 2023

Inéditos de Basílio da Gama, localizados por Augusto Massi, com tradução de Alexandra de Brito Mariano e Maurício Santana Dias.
Recepção poética de Basílio da Gama
Authors: Autores Vários
Published: February 2023

Poemas de Joaquim Inácio De Seixas Brandão, Claúdio Manuel Da Costa, Inácio José De Alvarenga Peixoto, Pedro Antônio Correia Garção, Filinto Elísio, Manuel Inácio Da Silva Alvarenga, João Xavier De Matos, Padre Manuel De Macedo Pereira De Vasconcelos, E. G. P., Antônio Dinis Da Cruz E Silva, Machado De Assis, Padre José Joaquim Correia De Almeida, Raul Pederneiras, Hermes Fontes e Gilberto Mendonça Teles.
Século XX
Authors: Mérou Martín García , Fazenda José Vieira , Viegas Arthur , Figueiredo Fidelino de , Pinto Manoel de Sousa , Monteiro Clóvis , Piccolo Francesco , Peixoto Afrânio , Souza Cláudio de , Maul Carlos , Franco Afonso Arinos de Melo , Leite S. I. Serafim , Holanda Sérgio Buarque de , Gomes Eugênio , Faustino Mário , Ávila Affonso , Frèches Claude-Henri
Published: February 2023

Recepção crítica de Basílio da Gama do século XX.
O interesse da crítica
Authors: Peters Carolina
Published: February 2023

Resenha de "Seja como for", de Roberto Schwarz.
Uma rosa é uma rosa na poesia de Mário Alex Rosa
Authors: Moreira Wagner
Published: February 2023

Resenha de "Poemas pitorescos", de Mário Alex Rosa.
Entre desenhar, pintar e ver
Authors: Rocha Angela
Published: February 2023

As pinturas aqui apresentadas foram realizadas até 2019, a maioria delas tendo participado de exposição individual realizada neste mesmo ano com o título de “Anotações sobre pintura”. prática humana, vista e revista e ainda frequentada pelo olhar de quem a vê. E em especial pelo olhar de Walter Benjamin ao escrever um texto que desvenda peculiaridades do seu olhar as imagens produzidas pela pintura e no desenho, procurando traduzi-los em palavras.
Anarquitetura e desfronteirização: dois movimentos sobre ruínas
Authors: Barzaghi Clara , Frajndlich Rafael Urano
Published: February 2023

Influenciado pelas proposições de Jack Halberstam a respeito das possibilidades de pensarmos uma estética do colapso, este ensaio busca articular a noção de anarquitetura, tal como encontrada nas obras de Gordon Matta-Clark, ao trabalho de Francis Alÿs a fim de pensar a violência organizada dos nossos tempos, à qual Mbembe nomeou “fronteirização”.
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells
Authors: Delgobo Murilo , Weiß Emil , Ashour DiyaaElDin , Richter Leon , Popiolkowski Lisa , Arampatzi Panagiota , Stangl Verena , Arias-Loza Paula , Mariotti-Ferrandiz Encarnita , Rainer Peter P. , Saliba Antoine-Emmanuel , Ludewig Burkhard , Hofmann Ulrich , Frantz Stefan , Campos Ramos Gustavo
Published: February 2023

Background:

In the past years, several studies investigated how distinct immune cell subsets affects post–myocardial infarction repair. However, whether and how the tissue environment controls these local immune responses has remained poorly understood. We sought to investigate how antigen-specific T-helper cells differentiate under myocardial milieu’s influence.

Methods:

We used a transgenic T cell receptor (TCR-M) model and major histocompatibility complex-II tetramers, both myosin-specific, combined with single-cell transcriptomics (single-cell RNA sequencing [scRNA-seq]) and functional phenotyping to elucidate how the antigen-specific CD4
+
T cells differentiate in the murine infarcted myocardium and influence tissue repair. Additionally, we transferred proinflammatory versus regulatory predifferentiated TCR-M-cells to dissect how they specially contribute to post–myocardial infarction inflammation.

Results:

Flow cytometry and scRNA-/TCR-seq analyses revealed that transferred TCR-M cells acquired an induced regulatory phenotype (induced regulatory T cell) in the infarcted myocardium and blunted local inflammation. Myocardial TCR-M cells differentiated into 2 main lineages enriched with either cell activation and profibrotic transcripts (eg,
Tgfb1
) or suppressor immune checkpoints (eg,
Pdcd1
), which we also found in human myocardial tissue. These cells produced high levels of LAP (latency-associated peptide) and inhibited IL-17 (interleukin-17) responses. Endogenous myosin-specific T-helper cells, identified using genetically barcoded tetramers, also accumulated in infarcted hearts and exhibited a regulatory phenotype. Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas T
H
17 partially converted toward a regulatory phenotype in the injured myocardium. Overall, the myosin-specific Tregs dampened post–myocardial infarction inflammation, suppressed neighboring T cells, and were associated with improved cardiac function.

Conclusions:

These findings provide novel evidence that the heart and its draining lymph nodes actively shape local immune responses by promoting the differentiation of antigen-specific Tregs poised with suppressive function.
Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response
Authors: Brala Debora , Thevathasan Tharusan , Grahl Simon , Barrow Steve , Violano Michele , Bergs Hendrikje , Golpour Ainoosh , Suwalski Phillip , Poller Wolfgang , Skurk Carsten , Landmesser Ulf , Heidecker Bettina
Published: February 2023

Background

Inflammatory cardiomyopathy is one of the most common causes of sudden cardiac death in young adults. Diagnosis of inflammatory cardiomyopathy remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation and monitor treatment response.

Methods and Results

A total of 233 patients were enrolled, with a mean age of 45 (±18) years, and 105 (45%) were women. The primary analysis included 209 adult subjects, of whom 66 (32%) were diagnosed with inflammatory cardiomyopathy, 17 (8%) were diagnosed with cardiac amyloidosis, and 35 (17%) were diagnosed with other types of nonischemic cardiomyopathy; 91 (44%) did not have cardiomyopathy. The second analysis included 13 patients with inflammatory cardiomyopathy who underwent immunosuppressive therapy after baseline magnetocardiography measurement. Finally, diagnostic accuracy of magnetocardiography was tested in 3 independent cohorts (total n=23) and 1 patient, who developed vaccine‐related myocarditis.

First, we identified a magnetocardiography vector to differentiate between patients with cardiomyopathy versus patients without cardiomyopathy (vector of ≥0.051; sensitivity, 0.59; specificity, 0.95; positive predictive value, 93%; and negative predictive value, 64%). All patients with inflammatory cardiomyopathy, including a patient with mRNA vaccine‐related myocarditis, had a magnetocardiography vector ≥0.051. Second, we evaluated the ability of the magnetocardiography vector to reflect treatment response. We observed a decrease of the pathologic magnetocardiography vector toward normal in all 13 patients who were clinically improving under immunosuppressive therapy. Magnetocardiography detected treatment response as early as day 7, whereas echocardiographic detection of treatment response occurred after 1 month. The magnetocardiography vector decreased from 0.10 at baseline to 0.07 within 7 days (
P
=0.010) and to 0.03 within 30 days (
P
<0.001). After 30 days, left ventricular ejection fraction improved from 42.2% at baseline to 53.8% (
P
<0.001).

Conclusions

Magnetocardiography has the potential to be used for diagnostic screening and to monitor early treatment response. The method is valuable in inflammatory cardiomyopathy, where there is a major unmet need for early diagnosis and monitoring response to immunosuppressive therapy.
TruthSift: A Platform for Collective Rationality
Authors: Baum Eric B.
Published: February 2023

TruthSift is a cloud-based platform that logically combines members’ contributions into a collective intelligence. Members add statements and directed connectors to diagrams. TruthSift monitors which statements have been logically established by demonstrations for which every challenge raised has been refuted by an established refutation. When members run out of rational objections, the result is a converged diagram succinctly representing the state of knowledge about a topic, including plausible challenges and how they were refuted. Previous computer systems for collaborative intelligence did not have a qualitatively better solution for combining contributions than voting and are subject to groupthink, interest group capture, and inability to follow a multistep logical argument. They did not settle issues automatically point by point and logically propagate the consequences. I review indications that many practically important statements most people believe to be firmly established will be revealed to be firmly refuted upon computer-assisted scrutiny. TruthSift also supports construction of powerful probabilistic models over networks of causes, implications, tests, and necessary factors.
The Scientific Biography of P.Ya. Galperin: Stages of Life and Creative Work
Authors: Stepanova Marina A.
Published: February 2023

Background. ! is article is dedicated to the 120th anniversary of the birth of Piotr Yakovlevich Galperin (1902–1988), an outstanding Soviet psychologist, the author of an original psychological concept and scienti" c school, and an organizer of psychological science. Objective. To reconstruct the main stages of the scienti" c biography of Piotr Yakovlevich Galperin. Results. ! e paper demonstrates the internal logic of P.Ya. Galperin’s developing scienti" c views in creating the theory of stage-by-stage formation of mental actions and concepts, which analyzes the process of formation of the main components of mental activity and develops a system of conditions for transforming an objective action into a psychological phenomenon. ! is biography is based on Galperin’s publications and speeches, memoirs of associates and family members, and numerous archival materials. All the periods of Galperin’s life are presented, re# ecting his participation, starting from the mid-1920s, in scienti" c and scienti" c-practical events. Particular attention is paid to Galperin’s work at M.V. Lomonosov Moscow State University (MGU): 55 years of Galperin’s professional and personal life (from 1943 until his death in 1988) were associated with the Philosophy Faculty, and then with the Psychology Faculty. Conclusion. ! e importance of preserving P.Ya. Galperin’s scienti" c legacy is shown and steps taken in this direction are indicated.