bluuebunny/crossref_metadata_2025 huggingface dataset:
Hambatan Komunikasi dalam Perkuliahan Daring pada Masa Pandemi Covid-19
Authors: Malik Abdul
Published: December 2021

This study was conducted to obtain an overview of the communication barriers between lecturers and students during the online class in the Covid-19 pandemic. The method used in this research is a case study and descriptive qualitative in which the result obtained from the research and the processed of the data about the communication barriers that occur in online lectures are deeply processed. The collected data consists of primary data that is obtained from online interviews and discussions with informan. Secondary data is obtained from various literature sources related to information and policies online lectures. Based on the result of research, show that at least there are three communication barriers that take place in online lectures, namely technological, environmental, and psychological barriers. Those three barriers are considered as lecture processed disruptions which implicate that there are students' difficulties in studying and understanding the lecture material well.
Peranan Humas Pemerintahan (Government Public Relations) dalam Menciptakan Reputasi Pemerintahan yang Baik
Authors: Lani Oktri Permata , Handayani Beni
Published: December 2021

The role of government public relations in the era of technological and information advancement is now no longer as a transmitter of information, but as a strategic element in supporting the successful implementation of government programs. Especially creating a reputation for good governance in the community. Therefore, the role of Public Relations Public Relations needs to be developed to be more proactive so that it is able to package information, oblique news that develops in the community and straighten it according to true, balanced and proportional facts so that people do not have bad perceptions about the government. The focus of the problem is the role of government public relations (Government Public Relations) in creating a good government reputation in the eyes of the community, as well as the objectives and functions of Government Public Relations (Government Public Relations) in creating a good government reputation in the eyes of the public. The research method uses literature study. Public Relations is designed based on serious research, planning and evaluation. The work process of Public Relations is a continuous circular process, and is a continuous process in the form of a spiral. In the implementation of the function of public relations or Public Relations requires, a variety of reliable expertise, people who can be trusted, supervision, coordination, attention to every detail and carried out in a professional manner. Public Relations must be able to master technical skills in disseminating information to achieve the goals that have been determined by the Public Relations. In this approach, Public Relations can use various communication channels, including interpersonal, public, group communication, mass media, both print and audio-visual and New Media.
DAMPAK LINGKUNGAN ORGANISASI DAN GAYA KEPEMIMPINAN TERHADAP KEPUASAN KERJA PETUGAS LAYANAN KESEHATAN (Studi Kasus Rumah Sakit Kota Cimahi)
Authors: Ferrari Oktavian Rizky
Published: December 2021

This study aims to determine the effect of the work environment and leadership style on employee job satisfaction in hospitals in the city of Cimahi. This study used a descriptive verification approach, and 91 employees were sampled using multiple regression analysis assisted by SPSS 23 software. The primary data of this study were obtained from questionnaires and interviews. While secondary data is obtained through notes and publications as well as literature. The results showed that there was an influence between work environment variables and leadership style on employee job satisfaction at health service hospitals. The influence of the work environment has an influence on employee job satisfaction so that employees are committed and loyal to the organization. Meanwhile, a good leadership style can increase employee job satisfaction. This is also evidenced by the Adjusted R Square value of 0.571 or 57.1%.
The Rise and Fall of Popular Australian Lawn Bowls 1864–2021
Authors: Georgakis Steve , Horton Peter
Published: December 2021

Lawn bowls is one of the oldest formally established British sports in Australia. This
paper provides an overview of the place of lawn bowls in Australian history and society
from 1864 to 2021 through four eras: British nationalism (1864–1900); middle class
sport (1900–1945); leading seniors sport (1945–1990); and decline (1990–2021). The
four eras cover the span of Australian lawn bowls and are based on historical data from
both primary and secondary sources tracing its rise and decline. The decline in lawn
bowls has been a combination of both internal and external factors. This paper is not a
purely chronological account of lawn bowls, but rather provides a framework to better
understand the place and role of the sport in Australian culture and society. The origins
of lawn bowls in Australia are directly linked to the cultural heritage that stemmed from
British settlement. Lawn bowls provides a vehicle to develop insight and understanding
into several past, current, and future social and cultural issues including seniors sport,
sport participation rates, gender relations, nationalism, class structures, urbanisation,
and the development of contemporary cities.
Семантический ореол и суггестивный потенциал метро-ритмических структур (на материале поэзии и переводов Сергея Гончаренко)
Authors: Goncharenko Elizaveta S.
Published: December 2021

В данной статье рассматривается вопрос о наличии семантической нагрузки у метро-ритмических структур как одного из видов репрезентации ритма поэтического текста. В качестве материала для исследования взята поэзия и поэтические переводы современного российского поэта и переводчика-испаниста С.Ф. Гончаренко. Количественный подсчет использования поэтом тех или иных метро-ритмических структур, сопровождаемый анализом тем, объединенных в его творчестве определенным ритмическим рисунком, а также лексических единиц, появляющихся в ткани поэтических текстов, объединенных одним ритмическим рисунком, позволяет выдвинуть гипотезу о том, что метро-ритмические структуры в творчестве отдельно взятого автора имеют определенный семантический ореол, а также обладают суггестивной функцией. Особое внимание уделяется использованию и трактовке хорея и смешанных ритмов.
Religión y libertad: la Inquisición romana, la cuestión Mortara y el debate sobre los derechos naturales en la prensa española (1858-1860)
Authors: Tcherbbis Testa Jimena
Published: December 2021

El artículo problematiza la relación entre religión y libertad a través del análisis de la circulación de una noticia de alcance global en la prensa española: el secuestro en 1858 del niño judío Edgardo Mortara por parte de la Inquisición romana. El análisis de la recepción de la noticia en un reino sin libertad religiosa permite problematizar el vínculo entre catolicismo y liberalismo a través de tres ejes: el poder temporal del papado, la intransigencia religiosa y la relación entre ley canónica y derechos naturales. Se demuestra que el asunto desató un debate entre los fieles católicos sobre la Inquisición, la legitimidad de la disidencia y un derecho natural emancipado de la tutela del pontífice.
Desarrollo empresarial y adaptación social inmigrante: La colectividad judía de Valparaíso-Viña del Mar. 1870-1950
Authors: Estrada Turra Baldomero
Published: December 2021

En este artículo se analiza el proceso de inserción y evolución laboral del colectivo judío de Valparaíso-Viña del Mar (Chile), teniendo en cuenta su capital cultural y social y haciendo notar sus estrategias para adaptarse a las posibilidades que le otorgaba el medio receptor, considerando las políticas públicas y disposición de la sociedad. Se concluye que existe una convergencia positiva entre el significativo capital cultural y social del grupo estudiado y un apropiado ambiente receptivo desde el medio de acogida.
Fischer, Irmtraud y Claassens, Juliana (eds.) (2020) La Biblia Hebrea (Antiguo Testamento). Profecía. Colección “La Biblia y las mujeres”. Estella: Verbo Divino, 375 pp.
Authors: Miralles Maciá Lorena
Published: December 2021

Fischer, Irmtraud y Claassens, Juliana (eds.) (2020) La Biblia Hebrea (Antiguo Testamento). Profecía. Colección “La Biblia y las mujeres”. Estella: Verbo Divino, 375 pp. ISBN: 978-84-9073-553-4.
José Martínez Delgado - Amir Ashur (2021) La vida cotidiana de los judíos de Alandalús (Siglos X-XII). Antología de manuscritos de la Guenizá de El Cairo (University of Cambridge). Córdoba: UCOPress.
Authors: Caballero Navas Carmen
Published: December 2021

José Martínez Delgado - Amir Ashur (2021) La vida cotidiana de los judíos de Alandalús (Siglos X-XII). Antología de manuscritos de la Guenizá de El Cairo (University of Cambridge). Córdoba: UCOPress. Editorial Universidad de Córdoba. 288 pp. ISBN: 978-84-9927-630-4
Félix de Oviedo (1577-1618): Arte y negocios con destino a Indias
Authors: Espinosa Spinola Gloria
Published: December 2021

Días antes de la llegada de la flota de la Nueva España al puerto de San Juan de Ulúa fallecía en la nao capitana Félix de Oviedo, capitán de artillería, comerciante, pintor y miembro de una de las familias de artistas más reputadas de la Sevilla de la época. Gracias a la documentación que se conserva en el Archivo General de Indias de Sevilla trazamos las relaciones personales y profesionales urdidas por la familia Oviedo en México, muestra de las redes familiares y clientelares tejidas en el Nuevo Mundo por quienes abandonaron su tierra natal en busca de nuevas oportunidades y riquezas.
San Pedro y San Pablo, una pareja de cuadros de Murillo
Authors: Regalado González-Serna Víctor Daniel
Published: December 2021

Por desgracia, a veces no se cuenta con suficiente apoyo documental en la investigación histórica. Esto ha propiciado que dos cuadros realizados por Murillo, un San Pedro y un San Pablo, hasta ahora se intuyera que debieron formar un conjunto pictórico fundamentándose en la hipótesis de los expertos en la obra de Murillo. Sin embargo, no había una prueba escrita que lo documentase. En este trabajo aportamos la confirmación documental que apuntaría que ambos se realizaron como un conjunto.
Teresa Laguna Paúl. Una Vida consagrada a la búsqueda de la excelencia
Authors: Laguna Paúl Teresa , Rodríguez Estévez Juan Clemente
Published: December 2021

Tras una larga y fecunda carrera profesional en la Universidad de Sevilla, Teresa Laguna acaba de jubilarse. Desde esta nueva posición, interrumpe su actividad investigadora para conversar con nosotros. Proyectando su mirada hacia el pasado, recuerda los hitos que marcaron su trayectoria vital y profesional. Como testigo privilegiado, ofrece valiosos testimonios sobre la conservación de la Catedral de Sevilla durante un período memorable. Pero, también, sin perder de vista el presente, reflexiona sobre sus inquietudes y algunos de los retos que afronta nuestro oficio en estos tiempos inciertos.
Main Tasks of Medical Personnel That Provide First Level of Medical Care During Treating and Prophilaxis of Depressive Disorders
Authors: Matviyets Liudmyla
Published: December 2021

This article provide new recommendations and main tasks that is needed to general practitioners – family doctors and family medical nurses in order to care about the patients with depressive disorders.
Overview of International Events of the European Association of Family Physicians Wonca Europe for the Years 2015-2016
Authors: Tkachenko Viktoriia
Published: December 2021

Європейська асоціація сімейних лікарів Wonca Europe – академічне та наукове товариство лікарів загальної практики–сімейної медицини в Європі, що включає 47 організацій-членів і понад 75 000 сімейних лікарів Європи.
Метою Wonca Europe є поліпшення якості життя людей шляхом заохочення і підтримки високих стандартів надання медичної допомоги в загальній практиці–сімейній медицині, проведення форумів для обміну досвідом та інформацією, заохочення і підтримки розвитку академічних, освітніх, науково-дослідних організацій лікарів загальної практики – сімейних лікарів, а також взаємодія лікарів загальної практики – сімейних лікарів з іншими світовими організаціями, що займаються питаннями охорони здоров’я та медичної допомоги.
Agranulocytosis in General Practice: Diagnosis, Treatment, Prevention and Clinical Case
Authors: Tkachenko Viktoriia , Sadovnik Yana , Vydyborets Nelia , Bondar Olha , Barkar Oksana
Published: December 2021

The article presents literature about classification, pathogenesis, clinical manifestations, diagnosis, treatment and prevention of agranulocytosis. The clinical case of agranulocytosis in practice of family doctor is presented, it developed in patient, who was taking antithyroid therapy. The attention of physicians to monitoring indicators of general and biochemical blood tests while taking antithyroid drugs has made.
Factors Associated with Masked Uncontrolled Arterial Hypertension in Patients Receiving Antihypertensive Treatment
Authors: Amosova Kateryna , Rudenko Yuliia
Published: December 2021

The aim of the study: to determine the frequency of the identify using a home blood pressure measurement (BP) masked uncontrolled arterial hypertension (MUAH), its sustainability and its associated factors at different stages algorithmization antihypertensive therapy on the basis of a fixed combination of perindopril and amlodipine in patients with uncomplicated hypertension.

Materials and methods. In an open prospective study were included 501 patients aged from 35 to 75 years (mean age 58,0±9.5 years). Of these, 221 cases (44.1%) patients with uncomplicated essential AH with AO ≥160/100 mm Hg (in individuals not previously treated) or ≥140/90 mm Hg in the case of the previously assigned antihypertensive therapy. The research design included a period of 6 months 6 visits: 7 days, 1, 2, 3 and 6 months. Step1by1step algorithm for the treatment of patients was provided for the appointment of a fixed combination of perindopril and amlodipine, consecutive appointment, if necessary, indapamide retard, spironolactone, moxonidine or doxazosin to achieve the target office BP.

Results. It was found that the proposed algorithm treatment not only gives the opportunity for 6 months to achieve therapeutic goals relative to the target level of office BP in 78.9% of patients, but in 56,8% decrease among them the percentage of persons with the MUAH.

Conclusion. According to the home definition of BP at different stages of antihypertensive therapy MUAH inherent to 23.5–51.6% of patients with controlled office AO and later persists not less than one-third of patients. Algorithmization antihypertensive therapy on the basis of a fixed combination of perindopril and amlodipine allows reducing the percentage of patients with MN of hypertension among patients with target office BP at 56.8 per cent for 6 months of treatment.
Survey of the Effect of Knowledge Obtained by Family Doctors After the Thematic Improvement Cycle «Management of HIV-patients for Family Doctor»
Authors: Matyukha Larysa , Avramenko Tetiana , Batsiura Anna , Boyko Valentyna , Veselova Tetiana , Matviets Liudmyla , Legkostup Liudmyla , Gusak Nataliia
Published: December 2021

Survey`s results of the impact of knowledge obtained by 111 family doctors through the thematic improvement cycle «Management of HIV-patients for family doctor» are presented in the article. The main achievements of this program are: raising awareness on the subject of HIV-infection/AIDS; formation of safe behavior of family doctors during their work with HIV-positive patients; establishing communication with patients; increase patient referrals for testing; awareness of the network of institutions and organizations servicing people living with HIV.
New Possibilities in Molecular Diagnosis and Prognosis of Diseases Associated with Human Papilloma Virus in Cervical Secretion
Authors: Veropotvelyan Petro , Tsehmistrenko Ivan , Veropotvelyan Mykola , Yaruchik Serhii
Published: December 2021

The aim of the article is to determine the importance of the systematic analysis of data available in modern publications – molecular markers of cervical discharge in the diagnosis of various diseases of the cervix associated with human papilloma virus (HPV). In addition, the prospects of studying protein and metabolic profiles of cervicovaginal discharge for predicting the course of neoplastic processes of the cervix. The article describes a number of protein markers in cervical defined for the early diagnosis of precancerous diseases and cervical cancer.
Timely Detection of Glaucoma in General Practice as a Means Prevent Late Diagnosis
Authors: Medvedovskaya Nataliia , Povch Zoreslava
Published: December 2021

The objective: justification of need of the organization of introduction of measures for timely identification of an ophthalmic hypertension in practice of the family doctor for timely diagnosis of glaucoma, the prevention of development of her terminal stage became a research objective.

Patients and methods. Outpatient and polyclinic units of five healthcare institutions of the city of Kiev in which primary help by the principles of the general medical practice – family medicine is given became scientific base of a research. Forms of account No. 12 «The report on the diseases registered at patients who live in the district of service of treatment and prevention facility» and questionnaires of a sociological research of risk factors of glaucoma (820 questionnaires) were primary material. Achievement of goals of a research demanded use of a complex of methods of a research, a basis for which was a systemic approach, namely: bibliosemantic, sociological, medico-statistical methods.

Results. Of a research it has turned out that prevalence of glaucoma continues to increase enough in high gear (for 14,9% from 2010 to 2014) that proves relevance of a problem of the prevention of a blindness and a low vision because of glaucoma in Ukraine and in the near future. Owning knowledge of modern risk factors which has the proved influence on formation of an oftalmogipertenziya, and over time and glaucomas, physicians of primary contact can actively form risk groups on glaucoma that will allow to unify and to individualize at the same time preventively – improving, medical and diagnostic medical care in each case and to objectify assessment of her results in dynamics.

Conclusion. Interaction in form of cooperation of the family doctor and ophthalmologist within the competences allows to perform effective long accounting of patients, preventing loss of visual functions by them for the account, first of all timely diagnosis of a disease (at an early stage), possible correction of the available risk factors of origin and progressing of glaucoma.
Improvement of the Preventive Care with the Help of Innovative Medical Information Systems
Authors: Latokha Illia
Published: December 2021

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The development of modern medical information systems (MIS) should be based not only on the number of possible actions, records and protection of the patient’s personal data, but also on the automated improvement of medical care for the population.
Today, having a huge digital potential with the beginning of electronic medical records, we do not use it at all in matters of accounting, research and control of adjustable risk factors for non-communicable diseases.
The article describes the development of a registration model and further analysis of adjustable risk factors using modern medical information systems without significant expenditures (time and money) for their improvement.
MIS is a software and hardware complex that prepares and supports the processes of collecting, storing and processing of information in medicine and health care.
The proposed changes in the MIS requires the the fixation of the following indicators – arterial hypertension, smoking, overweight, dyslipidemia, elevated blood glucose, sedentary lifestyle.
The fundamental condition for the operation of MIS is the maximum simplification of the procedure for medical workers, the elimination of ineffective processes of manual processing and analysis of medical data and the provision of effective information exchange with other information systems.
The frequency with which the system proposes to update the specified data, the inability to close the visit without entering information, should be individual for each patient, including age, levels and values of previously entered data.
One of the main tasks of MIS, solved in clinical institutions, is the further analysis of the data, the organization of the processing of this information. The introduction of a dynamic observation system with the identification of risk factors will make possible to analyze changes in the level of individual risk for each patient, assess the health of a society, a region, or draw conclusions on a national scale.
The Efficacy of the Therapeutic Exercises on Evminov Board with Use of the Glisson Loop in Patients with Degenerative Spine Diseases
Authors: Afanasieva Inna , Potaskalova Viktoriia , Khaitovych Mykola
Published: December 2021

Degenerative spine changes could be detected in 57% of persons in age of 20–29 years, in more then 95% – in age group of 40–49 years and in almost all persons older then 60, which determines the need in development of the effective methods for treatment and exacerbation prevention.
The objective: to evaluate the efficacy of the therapeutic exercises on the Evminov board with Glisson loop use in patients with spine degenerative diseases.
Materials and methods. The study included 349 patients with spine degenerative diseases. According to spine CT/MRI the protrusions of intervertebral discs of different parts of the spine were found in 166 patients (47.6%), and intervertebral hernias were described in 91 cases (26.1%). All patients were divided into 2 groups: group I included 205 people who received personalized therapeutic exercises on Evminov’s board without the use of nonsteroidal anti inflammatory drugs (NSAIDs), group II included 144 patients who took NSAIDs to redue cpain.
Results. After 4–6 weeks of treatment with Evminov’s board, all patients showed positive changes: in 47% of cases there was no pain at rest and in 53% of cases the pain decreased in intensity (from 7.8 mm to 3.7 mm on VAS). Group II patients in course of NSAIDs were recommended low-amplitude exercise therapy (up to 20°) to prevent exceeding the pain threshold, while most group I patients noted pain at an movement amplitude of 60–80° and performed exercises with the appropriate amplitude.
Group I patients showed improvement in the first week of treatment, while group II patients had improvement only in the third week of treatment.
Conclusion. Treatment of patients with the degenerative spine diseases on Evminov board with full-amplitude movements is more effective as for pain management and temp of pain decrease compare to low-amlitude exercises and NSAID use.
Modern Approaches to the Diagnosis and Management of Patients with Acute Gouty Arthritis in the Primary Health Care Setting
Authors: Khimion Liudmyla , Yashchenko Oksana , Danyliuk Svitlana , Sytiuk Tetiana
Published: December 2021

The diagnostic criteria and treatment strategy, which are used for patients with acute gouty arthritis in primary health care practice is given in the article. The algorithm of primary medicine doctor’s action in the management of patients with the acute gout attack is represented.
Therapy of II Type Diabetes Mellitus: Efficiency is Proved by Time
Authors: Muravliova Oksana
Published: December 2021

The article deals with the topical issue of endocrinology – diabetes mellitus (DM), which is spread with catastrophic speed and becoming a real epidemic of XXI century. Metformin hydrochloride for many years has proved its effectiveness in the therapy of II type diabetes mellitus. Therefore, Metformin hydrochloride is the main treatment for diabetes II type.
Urinary Tract Infection in Adults: Ways of Optimization of Complex Therapy
Authors: Shifris Iryna , Dudar Iryna , Loboda Olena , Krot Viktor , Krasyuk Eduard , Bryzhachenko Tetiana , Krylova Maryna , Savchuk Valentyna
Published: December 2021

The aim of the research: to study the efficacy of using Solidagoren in the complex treatment of the urinary tract infection (UTI).

Materials and methods. The study involved patients (n=51) aged from 18 to 65 years. All patients were verified UTI. The patients were divided into two groups: the main group (n=30) were prescribed an antibacterial drug in combination with medicinal herbal remedies Solidagoren; comparison group (n=21) who underwent only antibacterial therapy. The patient group was representative in terms of demographic indicators, nosology of UTI, course of the disease before the study began. The duration of antibiotics depended on the clinical variant of UTI and the dynamics of the main clinical and laboratory parameters. The duration of treatment with the help of Solidagoren was 30 days for all patients.

Clinical studies, complaints, data of objective status were assessed in dynamics three times: at the beginning of treatment, on the 4-th to 7-th day and on the 30-th day of observation. Bacteriological examination of urine was performed twice before treatment and on 17-20 day. Evaluation of the overall clinical efficacy was performed according to the dynamics of subjective and objective criteria for each patient.

Results. According to the results of microbiological study the pathogenic bacteria identified in 100% of cases. Only 57 selected strains of conditionally pathogenic aerobic bacteria: in 45 patients in the form of monoculture, 6 patients in the form of microbe associations. Among the isolated strains, more than 70% were gram1negative bacteria, dominated by Escherichia coli (56,14%). Gram1positive cocks in the structure of pathogens of UTI were around 30%.

It was found that patients in the comparison group normalization of laboratory values (leukocytosis, proteinuria, leukocyturia) were significantly slower than in the main group. Patients of the main group with symptoms such as lower back pain, dysuria, loss of appetite, weakness, already after 4-7 days of treatment bothered much less and this trend was observed for further observation. Eradication of the pathogen detected in 26 (86,7%) patients of the main group and only in 11 (52,3%) patients of the control group. Not established negative influence of the drug Solidagoren to the level of GFR.

Conclusion. The results of the study found that the use of the drug Solidaire in the treatment of UTI has a positive influence on dynamics of clinical and laboratory parameters, was well tolerated, promotes rapid eradication of pathogens UTI.
Risk Factors for Development of Glaucoma in the Practice of Family Doctor
Authors: Medvedovskaya Nataliia , Povch Zoriana
Published: December 2021

The objective: studying of risk factors of developing of glaucoma for formation of risk groups in daily practice of the family doctor, in particular timely identification of an ocular hypertension, the prevention of establishment for the first time of the diagnosis in her late stage became a research objective.
Patients and methods. Outpatient and polyclinic offices of five healthcare institutions of the city of Kiev in which primary help by the principles of the general medical practice – family medicine is given became scientific base of a research. Forms of account № 12 «The report on the diseases registered at patients who live in the area of service of treatment and prevention facility» and questionnaires of a sociological research of risk factors of glaucoma (820 questionnaires) were primary material. Achievement of goals of a research demanded use of a complex of methods of a research, a basis for which was a system approach, namely: bibliosemantic, sociological (questionnaire), medico-statistical methods.
Results. Оf a research it is proved that relevance of a problem of the prevention of a blindness and a low vision owing to glaucoma increases in Ukraine over the years. Modern risk factors of development of glaucoma which have the proved influence on formation of an ocular hypertension, and are studied later and glaucomas, knowledge of which will help physicians of primary contact with the patient to form actively risk groups on glaucoma that, in turn, allows to individualize at the same time preventively – improving, medical and diagnostic medical care in each case and to objectify assessment of its results in dynamics.
Conclusion. Knowledge the doctor of the general practice the family doctor of modern risk factors of development of glaucoma is necessary for her effective prevention as it is proved that timely diagnosis of a disease (at an early stage) does possible correction of the existing risk factors of emergence and progressing of glaucoma that is very important in daily practice of the doctor of the general practice – the family doctor.
Anxiety Disorders in General Medical Practice
Authors: Dzyak Liudmyla , Tsurakalenko Olena
Published: December 2021

Timely diagnosis and early initiation of adequate therapy of disorders of the alarming spectrum (AS) remains one of the urgent tasks of modern medicine. The article considers aspects of diagnosis and treatment of AS in General medical network, particularly were described the currently recommended schemes of application of the drug Eglonil and benefits of this drug.

Eglonil demonstrates the possibility of wide application of different variants of anxiety disorders, which gives the drug a special status among other psychotropic compounds.
Clinical Status and Lipid Metabolism Disorder and Antioxidant Protection in Patients with Coronary Heart Disease Depending on the State of Intestinal Biocenosis
Authors: Busygina Olha
Published: December 2021

The aim of the research: comparative study of parameters of lipid metabolism, products of lipid peroxidation and levels of antioxidant enzymes in patients with coronary heart disease with intestinal normobiocenosis and intestinal dysbiosis (DB) 1st and 2nd degree.

Materials and methods. The study involved 145 patients aged from 50 to 65 years, 29 (20%) of them were women. The control group (1st group) included 20 apparently healthy individuals with intestinal normobiocenosis. The comparison group (2nd group) consisted of 23 patients with coronary heart disease, postinfarct cardiosclerosis, chronic heart failure (CHF) the II functional class (FC) (NYHA), without signs of intestinal DB. The intervention group (3rd group) included 102 CHD patients with postinfarct cardiosclerosis, CHF the II FC and intestinal dysbiosis 1-st and 2-nd degree. Patients in all groups were comparable for age and sex.

Results. The study revealed that the presence of intestinal DB in CHD patients with CHF the II FC was associated with greater 1.5 times the frequency of angina attacks, with a greater 1.4 times frequency reduction of physical activity, with a longer history of CHD and more common burdened by CHD heredity. Patients with CHD with intestinal DB occur in more profound lipid disorders than patients without any signs of impaired intestinal biocenosis.

Conclusion. The presence of the initial stages of intestinal biocenosis disorders is associated with high levels of malondialdehyde in blood, diene conjugate, total cholesterol, cholesterol of low-density lipoproteins, atherogenic coefficient and significantly lower blood levels of superoxide dismutase and catalase in comparison with similar indicators in CHD patients with intestinal normobiocenosis.
Evaluation of the Effectiveness and Safety of Combination Therapy Using Drugs Vazonat and Entrop in Patients with Chronic Toxic Liver Damage
Authors: Velichko Valentyna , Cornovan Halyna , Kovalenko Svitlana , Danilchuk Halyna
Published: December 2021

The objective: to study the efficacy and safety of using in the complex treatment of cytoprotector Vazonat in combination with the nootropic medicine of entropy in patients with chronic toxic liver damage.

Patients and methods. There were examined 60 patients (36 men and 24 women) with signs of liver toxicity in age from 35 to 63 years. The average age of the examined was 43.2±1.3 years. All patients were divided into two statistically homogeneous groups (main and control) for 30 people in each. Patients in both groups received diet therapy, hepatoprotective, according to indications – antispasmodic, choleretic, antisecretory drugs, and enzymes. The main group of patients in the combined therapy was additionally appointed Vazonat 500 mg per day (2 capsules per day) and Entrop 100 mg per day in the first half of day for 1 month.

Results. Analysis of the obtained results testifies the effectiveness of additional use of drugs Vazonat and Entrop in combination with a standard hepatoprotective therapy in patients with chronic toxic liver in comparison of using only basic therapy. There was a positive dynamics of the main clinical syndromes. It was proved the positive impact of integrated therapy on the functional activity of the liver and also improving of cognitive abilities.

Conclusion. Inclusion in comprehensive standard hepatoprotective therapy of patients with chronic toxic liver damage drugs Vazonat and Entrop accelerates the normalization of the functional state of the liver.
Gastric Ulcer and Duodenal Ulcer in the Family Doctor Practice
Authors: Dudchenko Maksym , Tretyak Nataliia , Dudchenko Maksym
Published: December 2021

Peptic ulser disease is a chronic polyetiogical recurrent disease with impaired of neuro-endocrine and humoral mechanisms controlling secretory – trophic processes in the gastroduodenal area with ulcers development. It belongs to widespread diseases in the world with a tendency to increase. Peptic ulcers have different localization and dinical course. The treatment of the patient with ulcers should be staged, conservative comprehensive and individual in pharmacolotherapy prescriptions. The best variant in the treatment process is Hp and other submucous infection eradication with using in rehabilitation of the patients the combined drug Vipromak.
Correction of Psychological Status by Family Focused Technologies
Authors: Vdovychenko Serhii
Published: December 2021

The objective: to show a role of the family focused technologies in correction of psychological status and depression of frequency of pathology of pregnancy at women of high obstetric risk.
Patients and methods: for determination of efficiency of prophylaxis of pathology of pregnancy on the basis of use of the family focused technologies complex clinical-psychological and laboratory and tool examination of 300 women with factors of obstetric risk which were divided into two groups was conducted. In the main group – 182 women with motivation on partner labors to which provided training on system of individual preparation of married couple to labors. The control group consisted of 118 women with a traditional approach to pain management that have not been prenatal training.
Results. Use of the family focused technologies during pregnancy allows correction of psyhological status and to reduce significantly the frequency of the main complications of pregnancy, especially not incubation and premature births.
Conclusion. In our opinion, the technique is simple, available and can widely be used in practical health care at women with high obstetric risk.
Chronic Heart Failure (Lecture). Part I (Definition, Classification, Diagnosis)
Authors: Khimion Liudmyla , Yashchenko Oksana , Danylyuk Svitlana , Vataga Valeriia
Published: December 2021

The article shows the main current evidence on the diagnosis, course and treatment of chronic heart failure on an outpatient basis.
Evidence Based Medical Prevention: International Experience
Authors: Puzanovа Olha
Published: December 2021

The objective: was to study the international experience of evidence based preventive medicine development as well as to estimate its perspectives in Ukraine.

Patients and methods. Main principles and methods of scientific knowledge and research have been used including universal ones, methods of systemic approach, quantitative and qualitative information analysis, classification and systematization of theoretical and empirical data, hystorical and logical methods, health statistics as well). In total 529 scientific information sources have been studied, particularly a number of evidence based medicine (EBM) computer databases, special task forces recommendations and Cochrane reviews on prevention, Register of medical and technological documents for health care standards in Ukraine et al.

Results. The contribution of foreign scientific schools in the development of EBM has been determined, as well as the crucial role of scientific works carried out in the US and Great Britain in 1930–80s as to the development of evidence based preventive medicine. The international experience of the development and functioning of evidence based practice centers’ and special task forces on prevention has been summarized, as the experience of the development and implementation of recommendations on prevention in primary health care (PHC) in high income countries acceptable for Ukraine. The concept of evidence based prevention has been first proposed. It is revealed, that EBM implementation in Europe has been prioritized in both the field of infectious diseases prevention and PHC, while there are both the development of differentiated evidence based prevention and early evidence based diagnosis in PHC in the US.

Conclusion. The results proved importance of taking into consideration of international experience while evidence based PHC is being developed as a priority in Ukraine.
Strategy of Neurometabolic Pharmacotherapy: Targets, Problems, Instruments
Authors: Burchinsky Serhii
Published: December 2021

In the present paper a modern sights to problem of neurometabolic pharmacotherapy looking on correction of neuronal metabolism in clinical practice have been looked. Based on this point of view, the requirements to choice of optimal pharmacological tool of this strategy have been analyzed. A main attention paid to mechanisms of action and peculiarities of clinical use of drug Mexiprim (ethyl-methyl-hydroxypiridine succinat) with unique pharmacological and clinical properties, that make possible to realize the strategy of pathogenetically grounded neurometabolic pharmacotherapy in treatment of cerebrovascular disturbances, and other forms of pathology. A clinical efficacy of Mexiprim and its safety characteristics have been analyzed.
Rational Antibiotic Therapy of Acute Respiratory Infections in Outpatient Practice
Authors: Chulovska Uliana , Tolokh Olha
Published: December 2021

The choice of optimal antibiotic therapy in acute respiratory infections is an important and responsible job physician outpatient practices. Macrolide antibiotics are the drugs of choice in many cases of infectious diseases of the respiratory system. Antimicrobial spectrum, pharmacokinetic parameters and safety profile of spiramycin, classic representative of 16-membered macrolides, allow you to use it successfully for the treatment of community-acquired respiratory tract infections.
The Impact of Concomitant Chronic Pancreatitis on Prooxidant-antioxidant Status and Other Conditions in Osteoarthritis
Authors: Babynets Liliia , Maevska Tetiana
Published: December 2021

The study proved that patients with combined progress of osteoarthritis and chronic pancreatitis have reliable top-level activation of lipid peroxidation in terms of malonyc aldehyde and tissue destruction in terms of oxyproline, weakening of the antioxidant level (in terms of superoxide dismutase and SH-groups) and activation parameters of catalase and ceruloplasmin (p<0,05).
The authentic predictority of patients biological age, duration of combined clinical courses, the functional capacity of the pancreas in terms of fecal α-elastase, structural state by ultrasound criteria for progression effects of oxidative stress, accumulation oxyproline activation parameters catalase and ceruloplasmin, which statistically was reflected by the presence of mainly moderate of significant correlations between these groups of indicators have been identified.
Pharmacogenetic Testing in Nephrological Clinic
Authors: Ivanov Dmytro , Melnik Oleksandr
Published: December 2021

Selection of antihypertensive agents using pharmacogenetic tests and individual tolerance is essential in nephrology. Antihypertensive drugs are metabolized first line through various isoforms CYP (CYP2D6, CYP2C9, CYP2C19 and CYP3A4/5). These isoforms are the most significant for the patient in response to drug response. From a clinical point of view, it is important to establish the slow metabolizers (poor metabolism, PM), because it is they need to use other doses of antihypertensive drugs that different from the standard.
Principles of Diagnostic and Treatment of Coronary Artery Disease Combined with Chronic Obstructive Pulmonary Disease in Family Doctor Practice
Authors: Zaremba Yevheniia , Fedechko Mariana , Makar Oksana , Kopchak Lesia , Izhytska Nataliia
Published: December 2021

Combined pathology is one of the most spread problems in a family doctor’s practice. One of the first places is taken by the combination of ischemic artery disease and chronic obstructive pulmonary disease. It is connected with both wide spread occurrence of these pathologies and common risk factors together with pathogenic development mechanisms. Such combination causes diagnostics problems since the symptoms of one disease may mask the signs of the other. Chronic hypoxia, system inflammation characteristic of chronic obstructive pulmonary disease may have negative influence on the dynamics of ischemic artery disease, as a result of which complications occur more often. Apart from this, treatment requires a special approach because of possible negative influence of pharmacological drugs on the dynamics of combined pathology.
Comorbidity of Anxiety Disorders Chronic and Pain Syndromes: Especially Treatment
Authors: Svyrydova Nataliia
Published: December 2021

Today proved comorbidity anxiety disorders and pain, and, as the clinical practice, chronic pain can cause anxiety and depressed mood accompanied by symptomatic persistent fears. Proven important role of dopamine in changes in pain sensitivity in patients with chronic disorders of the central nervous system. The change in pain sensitivity in patients with impaired dopamine activity in different clinical conditions could have important implications outcomes severity of pain, and changes in dopamine signaling mechanisms in chronic pain an opportunity to influence treatment strategy. In recent years, along with a wide noradrenalin study and serotonin receptors in the pathogenesis of depressive disorders spectrum, set the sensitivity of dopamine receptors and considerably more pronounced prolactin response to sulpiride administration in depression. Sulpiride belongs to a group of atypical neuroleptics and so in the early years of clinical study, most research has been directed to determine its effectiveness in psychotic disorders. Accumulation of current clinical data revealed wide spectrum efficiency sulpiride and its important differences from the classical neuroleptics.
Changes Porto-hepatic Blood Flow in Patients with Cirrhosis of the Liver, Combined with Chronic Bronchitis
Authors: Virstyuk Nataliia , Kobitovych Iryna , Gerasymchuk Olha
Published: December 2021

The objective: study the features of porto1hepatic blood flow in patients with alcoholic liver cirrhosis (ALC) in conjunction with chronic bronchitis (CB) according to Doppler ultrasound.

Patients and methods. The study involved 60 patients who were hospitalized, 20 ALC patients in stage B according to Child-Pugh without CB (Ist group), 20 ALC patients in stage B according to Child-Pugh combined with CB in the acute phase (IInd group), 20 patients exacerbation of chronic bronchitis, for which there was no evidence of digestive system diseases (IIIrd group). All patients underwent a complex ultrasonic research techniques scanning in B-mode, the VD-mode, color duplex scanning using «Hitachi EUB 7000» ultrasonic scanner connected to the Doppler flourimetr was visualized main arterial and venous vessels of hepatic and splenic pools.

Results. Changes porto-hepatic blood flow were most pronounced in patients with ALC in combination with CB when compared with patients of groups I and III (p<0,05) according to the obtained Doppler indices: diameter of the hepatic artery was 5,55±0,19 mm, portal vein – 12,60±0,17 mm, where increased by 159,12% and 53,56%, respectively (p<0,05) higher than those in healthy individuals.

The diameter of the splenic artery and splenic vein at the ALC for combination with CB significantly increased compared with control on 31,13% and 35,67%, respectively (p<0,05).

Linear and volumetric blood flow rate in portal vein decreased in this group of patients, 60,24% and 22,68%, respectively (p<0,05) compared with healthy individuals, the linear velocity of blood flow in the splenic vein also significantly slowed down compared to the control on 41,06% (p<0,05), and the volumetric blood flow velocity v. lienalis grew by 155,80% (p<0,05).

Among the characteristics of the arterial blood flow hepato-splenic system Gosling pulsatility index (PI) and Pursello resistance index (RI) of hepatic artery also Pursello resistance index (RI) of splenic artery significantly grew in ALC patients in combination with CB 147,20%, 65,49% and 32,31%, respectively (p<0,05) compared with the control group.

Maximal systolic velocity of blood flow in the hepatic artery of patients – grew by 8,95% (p<0,05). End diastolic blood flow velocity in the hepatic artery tended to decrease on 13,36% (p<0,05) compared with healthy individuals.

Conclusion. Violation of porto-hepatic blood flow in patients with ALC is characterized by its redistribution in the veins of the portal system in the direction of the spleen with a decrease in the average linear and the volumetric velocity in the portal and hepatic veins, increasing the resistance index in the interlobar arteries.
Condition Factors of Systemic Inflammatory Response and Monospacing Homeostasis in Patients with Ischemic Heart Disease with Normaliens and Intestinal Dysbiosis
Authors: Busygina Olha
Published: December 2021

The aim of the research: assessment of monospacing homeostasis in patients with coronary heart disease (CHD) depending on the state of intestinal biocenosis.

Materials and methods. There were examined 145 patients, who were divided into three groups. The control group included 20 practically healthy persons with normal intestinal biocenosis. The comparison group consisted of 23 patients with ischemic heart disease, postinfarction cardiosclerosis, chronic heart failure (CHF) II functional class (FC) (NYHA), without signs of intestinal dysbiosis. The main group included 102 patients with CHD and postinfarction cardiosclerosis, chronic heart failure II FC and intestinal dysbiosis of 11st and 21nd degrees. Patients in all groups were comparable for age and sex. Was used the anthropometric, clinical, biochemical, immunoassay, enzymatic methods.

Results. It was found that the presence of intestinal dysbiosis is associated with more pronounced activation of the systemic inflammatory response and humoral immune response in large decreases of the activity of the cellular component of the immune system and phagocytic function of neutrophils.

Conclusion. The results of the study demonstrated more distinct changes in monospacing homeostasis in CHD patients in conditions associated DB intestine compared monosplines status of CHD patients with normaliens the intestine.