bluuebunny/crossref_metadata_2025 huggingface dataset:
Reciprocal Union in St. Thérèse of Lisieux Story of a Soul - Sheldon R. Tabile, O.Carm.
Authors: Tabile Sheldon
Published: October 2022

This paper takes a spiritual perspective on St. Thérèse of Lisieux's Story of the Soul. The central focus of this study is on the text's portrayal of God and St. Thérèse of Lisieux as partners in a reciprocal relationship. The reader's ability to read becomes sharper as he explores the soul's receptivity, reciprocity, responsiveness, and responsibility in response to God's action. In spiritual reading, the emphasis is on identifying the ongoing relationships in the text. Readers are given knowledge of reciprocal union in this manner: the soul completely surrenders to God, and He fully submits to them in this relationship.
 
References
John of the Cross. St. John of the Cross Collected Works. Trans. Kieran Kavanaugh, OCD and Otilio Rodriguez, OCD. Washington: ICS, 1991.
Thérèse of Lisieux. Story of a Soul, Study Edition. Trans. Translation by John Clarke, OCD. Washington: ICS, 2019.
Waaijman, Kees. Spirituality. Forms, Foundations, Methods. Leuven: Peeters, 2002.
Welzen, Huub. Biblical Spirituality, Contours of a Discipline. Leuven: Peeters, 2017.
The Regulation on Foreign Subsidies Distorting the Internal Market – Outline of the Provisional Agreement
Authors: Ritzek-Seidl Simone
Published: October 2022

Towards the end of June 2022 the negotiators of the European Parliament and of the Council reached a provisional agreement on the Regulation on foreign subsidies distorting the internal market. This article describes the main points of the provisional agreement, pertaining to the key concepts of the Regulation, guidelines on certain provisions, thresholds for notifying concentrations and public procurement tenders, adapting those thresholds by delegated acts, the relationship with third countries as regards subsidies, certain procedural aspects and the retrospective application of the Regulation.
Between State Aid, Trade and Antitrust: The Mixed Procedural Heritage of the Foreign Subsidies Regulation and the Overarching Principle of Non- Discrimination
Authors: Laprévote François-Charles , Lin Wanjie
Published: October 2022

The FSR intends to fill a regulatory gap between trade law, State aid and antitrust law, and achieves this through a unique blend of familiar concepts and rules, drawing from the rich legal traditions of the EU State aid, antitrust, and trade defense regimes. This legal inheritance can be observed throughout the FSR’s procedural framework, including the structure of its review procedures, the Commission’s investigative powers, and the rights of defence of undertakings. Given its legacy, there will be a continuing dialogue between the FSR and these other regulatory systems, possibly with the FSR exerting its own influence, such as on due process rights under the State aid regime.
Substantive and Procedural Parallels and Overlaps Between Art. 107, 108 TFEU and the (Draft) Regulation
Authors: Blazek Sarah , Hegener Jochen Christoph
Published: October 2022

Similarities between the European Commission’s proposal for a regulation on foreign subsidies distorting the internal market and State aid law have been widely noted, not least because of their similar goals. This article analyzes overlaps and parallels between both substantive and procedural rules in the European Commission’s proposal and State aid law. In particular, the article focuses on the extent to which precedents regarding the definition of State aid may also inform the application of the proposal and its definition of foreign subsidies.
Ex Officio Third Country Subsidies’ Review – Similarities with and Differences to State Aid Procedures
Authors: Weiß Wolfgang
Published: October 2022

The Commission’s proposal for a regulation on third country subsidies inter alia provides for ex officio supervision by the European Commission, comparable to its supervision in the field of state aid. Nevertheless, there are significant divergences. This article compares the instruments with regard to ex officio proceedings and analyzes similarities and differences in the procedures and investigative powers, most importantly that the addressee of a decision under the new regulation is an undertaking, not a Member State, and that the decisive facts for assessing whether a benefit to an undertaking was granted have taken place in a foreign country.
Prevalence of depression symptoms among staff at the city institute for emergency medical services Belgrade
Authors: Živanović Slavoljub , Petrov-Kiurski Miloranka
Published: October 2022

Introduction: According to the WHO, depression is a common mental disorder where workplace conditions play a significant contributing factor. Objective: To examine the prevalence of depression symptoms and the relationship with sociodemographic characteristics in staff at the Institute for Emergency Medical Services (EMS) Belgrade, i.e., physicians, medical technicians, drivers and administrative workers. Methodology: The research was conducted at the City Institute for EMS in Belgrade in the period from December 1 to December 6, 2007. The questionnaire consisted of questions about the sociodemographic characteristics of participants, a self-assessment questionnaire for depression PHQ-9 and a question about the use of antidepressants. The data that was collected was statistically processed with the software package SPSS 20.0 Results: The study included 118 participants, 58,47% were male and the average age was 40,77 ± 8,86. The result of the PHQ-9 test showed that 30% of the participants had symptoms of subsyndromal depression, 11% had symptoms of mild depressive episode, most often in female participants (p = 0,023) and in administrative workers (p = 0,003). Depressive symptoms was present in 16.95% of respondents. Out of the 9 listed symptoms of depression, fatigue/extreme exhaustion were most commonly present (47,46%) as well as feelings of emptiness and hopelessness (43,22%). Only 11,86% of participants used antidepressants and there was no statistically significant difference in relation to the observed parameters. Conclusion: Symptoms of subsyndromal depression is significantly present among the EMS staff in Belgrade, more often among female participants and those working in administration.
Watching the City with Pleasure
Authors: Andersen Nexø Tue
Published: October 2022

The essay examines the intersection between aesthetic the-ory and representations of the city in the periodical essay The Spectator (1711-1714). Focusing on this intersection allows for an analysis of the cultural work aesthetic pleasure is supposed to do according to The Spectator, and also shows key differenc-es between “spectatorial” and later, Kantian aesthetics. In The Spectator aesthetic pleasure has to do with producing a model for how one should relate to the realm of politics—rather than disin-terest, the precondition of aesthetic pleasure turns out to be disengagement. Read through the lens of the city, aesthetic pleasure turns out to be a key component in The Spectator’s vision of how to live a good life as a privileged subject of a modern state.
The knowledge and practices of caregivers regarding the administration of oral liquid medication to children at a healthcare clinic in Bloemfontein, South Africa
Authors: Bezuidenhout W , Cummings J , De Klerk L , Finlay D , Lewis C , Pienaar L , Bouwer A , Coetzee R , Joubert G
Published: October 2022

Background. Children are dependent on their caregivers to accurately administer medication to them.Objectives. To determine the knowledge and practices of primary caregivers regarding their methods of oral liquid medication administration, preferred measuring utensils, accuracy of preferred measuring utensils and different medication classifications that they collected. The study was conducted at Pelonomi Polyclinic Pharmacy, Bloemfontein, South Africa.Methods. A quantitative, cross-sectional descriptive study (with analytical aspects) was conducted, which used consecutive, convenient sampling. The pharmacy staff assisted in recruiting participants, after which a screening form was used to determine their eligibility. Participants were provided with an information document and consent form. The liquid medication was classified according to a drug classification list, and one medication was selected for the focus of the structured interview. The questionnaire was completed using REDCap. Thereafter, researchers used the information on the medication label to determine the accuracy of the caregiver’s answers.Results. The majority of the 89 participants (56.2%) answered all 3 administration-related questions correctly, with 84.3% answering the questions regarding quantity and frequency correctly. The medication measure (43.8%) was the preferred measuring utensil for any liquid medication at home, and the syringe (53.9%) for the selected liquid medication used in the interview, both accurate measuring utensils. Most children (56.2%) were prescribed ‘other medication’ (e.g. vitamins and mineral supplements), followed by analgesics (47.2%) and antibiotics (42.7%).Conclusion. Primary caregivers at Pelonomi Polyclinic Pharmacy know how to administer oral liquid medication to children accurately. Most caregivers indicated that they use accurate measuring utensils
Transnational Corporations in Transregional Initiatives: Goals and Problems of Participatio
Authors: Kuznetsov Denis Andreevich , Rudoman Kirill Alekseevich
Published: October 2022

The activities of transnational business have already become an integral part of the global political and economic development, affecting integration processes in the world. However, the dichotomy of relations between a state and TNC in the context of trans-regional development is not fully understood. The article analyzes the consequences of quantitative and qualitative strengthening of TNC in the world political processes on the example of four major trans-regional projects - the Trans-Pacific Partnership, the Trans-Pacific Trade and Investment Partnership, European Union and MERCOSUR Free Trade Agreement, the Belt and Road Initiative. The authors define the tools promoting each project, which reflect the nature of interaction between states and TNC at the trans-regional level. In addition, the study highlights various objectives of TNC participation in a particular trans-regional association, as well as appropriate resources for the implementation of their interests, which can generally be divided into economic, political and image. To answer the question on how states and transnational business interdepend not only in trans-regional processes but also in the world economy, the authors, based on the practice of modern world politics, construct models of the relationship between states and business and come to the conclusion that the type of interaction these actors use largely depends on states internal political system, as well as their foreign policy goals. Nevertheless, despite the increasing role of TNC as an influential actor in world politics, at the moment it is premature to declare that they are completely independent from states.
The Problem of Poverty in a Society with Excessive Socio-economic Inequality
Authors: Ermakova Eka , Igonina Alina Aleksandrovna
Published: October 2022

The object of the study is the phenomenon of socio-economic inequality in the world and Russia. The subject of the study is poverty as an integral phenomenon of the lower strata of society with its excessive differentiation by income and wealth. The purpose of the study is to determine the depth of the problems of socio-economic inequality and poverty during the spread of the COVID-19 coronavirus pandemic. The research methodology is based on the use of the principles of integrated and systematic approaches, general scientific and special methods of economic science. The information base of the study was data from the National Statistics Service of the Russian Federation, data from opinion polls conducted by VTSIOM and the Levada Center, the World Bank.   The article is devoted to the problems of socio-economic inequality and poverty as interrelated, having common roots, causes, consequences and similar solutions. The depth of the studied problem is illustrated by statistical data in relation to Russia and individual countries of the world. Particular attention is focused on the accessibility of the poorest segments of the population to health services during the spread of coronavirus infection. The thesis that the pandemic has made the poor even poorer is confirmed. The authors cite alternative official statistics - the results of sociological surveys conducted by various organizations in order to emphasize the scale and depth of the problem of poverty and vulnerability of the population classified as the lower decile.
Travel-related humour and COVID-19
Authors: Pabel Anja , Turnšek Maja
Published: October 2022

This study aims to provide an overview of humorous travel-related memes shared during the COVID-19 pandemic. A total of 80 Internet memes were content analysed for emergent themes. The findings reveal three major themes: playful aggression, making fun of one’s longing for travel, and making fun of new travel realities. The identified themes were linked to the existing literature to better understand the memes being studied. The analysis of memes provides a methodologically agile way to study conditions that may otherwise be overlooked, e.g., peoples’ travel-related desires and concerns while in lockdown.
Deep reinforcement learning based offloading decision algorithm for vehicular edge computing
Authors: Hu Xi , Huang Yang
Published: October 2022

Task offloading decision is one of the core technologies of vehicular edge computing. Efficient offloading decision can not only meet the requirements of complex vehicle tasks in terms of time, energy consumption and computing performance, but also reduce the competition and consumption of network resources. Traditional distributed task offloading decision is made by vehicles based on local states and can’t maximize the resource utilization of Mobile Edge Computing (MEC) server. Moreover, the mobility of vehicles is rarely taken into consideration for simplification. This article proposes a deep reinforcement learning based task offloading decision algorithm, namely Deep Reinforcement learning based offloading decision (DROD) for Vehicular Edge Computing (VEC). In this work, the mobility of vehicles and the signal blocking commonly in VEC circumstance are considered in our optimal problem of minimizing the system overhead. For resolving the optimal problem, the DROD employs Markov decision process to model the interactions between vehicles and MEC server, and an improved deep deterministic policy gradient algorithm called NLDDPG to train the model iteratively to obtain the optimal decision. The NLDDPG takes the normalized state space as input and introduces LSTM structure into the actor-critic network for improving the efficiency of learning. Finally, two series of experiments are conducted to explore DROD. Firstly, the influences of core hyper-parameters on the performances of DROD are discussed, and the optimal values are determined. Secondly, the DROD is compared with some other baseline algorithms, and the results show that DROD is 25% better than DQN, 10% better than NLDQN and 130% better than DDDPG.
Disseminated Tuberculosis with Neurotuberculosis Presenting as Status Epilepticus: A Case Report
Authors: Acharya Sourya , Shukla Samarth , Goyal Aditi , rshad VS I , Bagga Charan
Published: October 2022

Disseminated Tuberculosis (TB) results when the infection spreads though lymphohaematogenous route involving multiple organ systems. Irrespective of the availability of diagnostic modalities and treatment, it is usually diagnosed late increasing the mortality. Though, it usually occurs in immunocompromised patients, yet, incidence of disseminated TB is rising in immunocompetent subjects. This case report describes a 48-year-old male who presented to the Emergency Department (ED) with status epilepticus. Investigations revealed neurotuberculosis along with generalised tubercular lymphadenopathy involving cervical, axillary, mediastinal and abdominal lymphnodes. Diagnosis was confirmed after Cerebrospinal Fluid (CSF) and lymphnode biopsy. He was started on first line antitubercular drugs and tapering dose of tab. Prednisolone over one month. He was discharged after two weeks of hospitalisation. At 15 days follow-up the patient was asymptomatic.
Perception, Working Experience and Psychiatric Morbidity among Information Technology Professionals during COVID-19 Lockdown: A Cross-sectional Survey
Authors: Ray Anirban , Das Subrata , Sanyal Debasish , Majumder Mainak Sankar
Published: October 2022

Introduction: In the year 2020, the functioning of the world changed in a big way. For a large part of the year, the world stayed locked indoor, due to the novel Coronavirus Disease -2019 (COVID-19). The need for Information Technology (IT) has reached a new height, and this is certain to persist. Though the IT professionals were mostly working indoors in 'work from home' mode, work pressure and boredom increased according to few studies. Work from home also has different set of employees’ expectations and organisational responsibilities. Aim: To assess the psychiatric morbidity working experience and related perspectives of the new normal, as perceived by IT professionals. Materials and Methods: This cross-sectional survey was conducted in Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata, West Bengal, India, between May 2020 and August 2020. A Google form-based survey was done which aimed to reach throughout the country. Consent was included as the first question of the form. An ethical clearance was taken from Institutional Ethical Committee of IPGME&R, Kolkata in convenience sampling of IT professionals. For the survey, a semistructured questionnaire was developed and Brief Resilience Coping Scale (BRCS), Ten Items Personality Inventory (TIPI), and K6 psychiatric morbidity screener were used to measure the psychiatric morbidity. Snow ball sampling methods was used to get the sample through free sharing of google forms over the internet. Relevant statistical tests were used to analyse the data, where p<0.05 had been considered significant. Results: Total 72 IT professionals responded to the survey but only 71 were included due lack of informed consent. About 20 (28.2%) showed a high risk of losing their job as per their perception and 35 (49.29%) were highly worried about having COVID-19, while 44 (61.9%) were highly worried about bringing the infection home. 78.9% (n=71) showed screener positive psychiatric morbidity. Psychiatric morbidity was only dependent on “emotional stability” as a personality trait and “risk of Job loss” by regression analysis. Total 67 people were working from home, 37 (55.22%) felt the family time had increased, 28 (41.79%) felt family was happier due to work from home. Conclusion: This study showed the psychiatric morbidity of IT professionals was quite high and it was not related to their resilience level and own perception of morbidity. Psychiatric morbidity was determined by emotional stability, and the threat of losing jobs. It also shed light on disease perception and state of work perception of IT professionals. Though work from home mode may compromise the work quality slightly but it was good for the families and personal stress levels of the employees.
Relationship Between Lithium Dose, Serum Concentration and Duration of Lithium Therapy with Cutaneous Side-effects in Bipolar Affective Disorder Patients
Authors: Priyadharshini B Suganya , Ibrahim Syed Ummar , . Karthikeyan , . Jeevithan
Published: October 2022

Introduction: Lithium has been used in the treatment of mood disorders for more than five decades. Despite a few studies focusing on the relationship between the dose of lithium, serum lithium levels, duration of therapy, and cutaneous side-effects, results remain inconclusive. Lithium is known to cause multiple cutaneous side-effects like acneiform eruptions, psoriasiform eruption, seborrheic dermatitis, and follicular keratitis. Aim: To evaluate the relationship between cutaneous side-effects of lithium with the serum lithium levels, dosage and duration of lithium therapy in bipolar affective disorder patients. Materials and Methods: An ambispective observational study conducted among 52 bipolar affective disorder patients on lithium therapy recruited by convenient sampling methods from both Inpatients and Outpatient Psychiatry Units of PSG Institute of medical sciences and research, Coimbatore, Tamil Nadu, India, June 2014 to August 2014. The patients with bipolar affective disorder who are either newly started on lithium or already on lithium therapy were included in the study. They were followedup to assess the effect of lithium dosage, duration of lithium and serum lithium level with skin lesions, once a month for six months and once in two months for one year. Kaplan-Meier survival analysis was done with varying lithium dosages and serum lithium levels. Association between the lithium dose and serum lithium levels with the cutaneous side-effects were calculated using the survival analysis with the p-value of <0.01. Results: Out of the total, 59.6 % of the participants were in the age group less than 40 years and 34.6 % were in the age group 40-60 years. There was almost equal distribution of males and females, 51.9% and 48.1%, respectively. Overall, 38.46% participants had cutaneous lesions. Various lithium dosage and serum lithium levels did not correlate statistically with skin reactions upto one year. Survival analysis at the end of 10 years revealed that participants with higher dosage and serum levels had higher prevalence of skin lesions (40% vs 4%: 47.1% vs 6.6% respectively, p-value <0.001). The cumulative proportion of skin lesions at the end of three, five, seven and 10 years for higher dose (>800 mg/day) was 38%, 46.9%, 52.2%, 59% and for higher lithium levels (>0.8 mEq/L) was 41%, 58.2%, 65.2%, 73.9%. Conclusion: The patients who were treated with lower dosage and who had lower serum lithium level had reduced risk for cutaneous lesions. Lithium continued to exert its mood stabilisation property even when the serum level was maintained less than 0.8 mEq/L. This resulted in better compliance
Correlation of Serum Biochemical Parameters and Oxidative Stress in Malnourished Children: A Case-control Study
Authors: Kumari Nilima , Goyal Manish , Tiwari Ravi Kant
Published: October 2022

Introduction: There are evidence regarding enhanced oxidative stress in the form of serum Malondialdehyde (MDA) and depleted activities of serum zinc and iron in malnourished children. The deficiency of trace elements predisposes the susceptibility to various infections. Changes in oxidant and antioxidant levels may be responsible for grading in Protein Energy Malnutrition (PEM). Aim: To correlate the levels of serum biochemical parameters such as proteins, zinc, iron with oxidative stress in the form of Malondialdehyde (MDA), in malnourished children of 1-5 years of age and also to compare the findings with age and gender matched well-nourished children. Materials and Methods: This case-control study was conducted in the Biochemistry Department at Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India, from January to December 2014. A total of 202 children (aged 1-5 years) were included in the study. Out of these, 103 children were undernourished and 99 children were healthy control. Out of 103 undernourished children 46 were severe malnourished and 57 were moderate malnourished. Blood samples were analysed for the estimation of serum zinc, iron, MDA, albumin and total protein. T-test, one-way Analysis of Variance (ANOVA) and Pearson correlation were used for statistical analysis and p-value <0.001 was considered significant. Results: Mean weight of moderate malnourished (10.44±2 kg) and severe malnourished children (9.36±1.54 kg) were significantly low (p-value <0.001) when compared with control group (12.73±2.36 Kg). Compared to controls (0.71±0.18 nmol/mL) the serum MDA level were significantly high (p-value <0.001) in both moderate (1.84±0.38 nmol/mL) and severe (3.44±0.59 nmol/mL) malnourished children. Serum zinc and serum iron levels, serum total protein and albumin of malnourished cases were significantly low (p-value <0.001) as compared to the control subjects. Conclusion: Compared to control, the malnourished children had significant high level of serum MDA while low levels of serum zinc, iron, albumin, globulin and total proteins. Early replacement of antioxidants, nutrients, proteins, zinc and iron supplement could be useful in the therapy of this disease.
Delftia acidovorans: A Rare Pathogen Isolated from Pleural Fluid in an Immunocompromised Host
Authors: Perumal P Ganesh , Appalaraju B , Thiruvengadam Preethi
Published: October 2022

Delftia acidovorans is an aerobic, non fermentative gram negative rod that belongs to the Pseudomonas ribosomal Ribonucleic Acid (rRNA) homology Group III. The sources of isolation are sludge, biological waste water treatment plants. Patients in hospitals or with compromised immune systems are more likely to be affected. Delftia acidovorans can result in infectious endocarditis, ocular infections, otitis media, peritonitis, urinary tract infections, empyema, cavitary and interstitial pneumoniae, and nosocomial bacteraemia, including bacteraemia linked to central venous catheters in people with compromised immune systems. This case report is about a 57-year-old male with complaints of loss of appetite for six days and vomiting, as well as loss of weight. He was diagnosed with HIV two years ago and was on HAART (Highly Active Antiretroviral Therapy). This atypical bacterium was isolated from pleural fluid of the patient; and he was managed with albumin infusion, anticoagulants, beta blockers, fluid and salt restriction and intravenous antibiotics. It is an emerging source of Gram negative bacilli which is normally a non pathogen causing serious infections among immunocompromised patients.
SEQUÊNCIA DE ENSINO INVESTIGATIVA EXPERIMENTAL COM A UTILIZAÇÃO DE DISPOSITIVOS MÓVEIS: UM OLHAR METACOGNITIVO NA APRENDIZAGEM DE CIÊNCIAS
Authors: Souza Neto Luiz Gonzaga de , Lima Kênio Erithon Cavalcante
Published: October 2022

A pesquisa teve a finalidade de analisar uma sequência de ensino investigativa experimental, em que utilizamos a aprendizagem móvel, visando verificar se eram empregadas estratégias metacognitivas no Ensino de Ciências. O percurso metodológico envolveu um docente colaborador de Ciências e seus vinte alunos do 7º ano. Para coletar o corpus, utilizamos as interações discursivas, os materiais desenvolvidos durante a sequência, o diário de bordo do pesquisador e uma entrevista pós-sequência com os alunos. Para identificar e analisar as estratégias metacognitivas no estudo, seguimos as categorias de ordem pessoal, procedimental, da compreensão do problema e do conhecimento. Por meio da análise, constatamos a importância do docente ao fomentar as estratégias metacognitivas no processo de aprendizagem dos alunos e as implicações estabelecidas entre a atividade experimental e os smartphones na sequência.Considerando o exposto, apresentamos elementos atuais de uma sala, trazendo a tecnologia como suporte de reflexão para o aprendizado do aluno.
A FORMAÇÃO CONTINUADA DE PROFESSORES E A RELAÇÃO UNIVERSIDADE-ESCOLA NA ÁREA DE CIÊNCIAS DA NATUREZA E SUAS TECNOLOGIAS: ESTADO DO CONHECIMENTO
Authors: Michelon Karen Regina , Güllich Roque Ismael da Costa
Published: October 2022

Este artigo buscou investigar sistematicamente teses e dissertações encontradas na base de dados da Biblioteca Digital Brasileira de Teses e Dissertações do Instituto Brasileiro de Informação e Tecnologia sobre Formação Continuada de professores de Ciências. Para tanto, a análise foi direcionada para a relação Universidade-Escola (UE), apresentando um montante de 17 trabalhos no corpus da pesquisa. O estudo é uma pesquisa do tipo estado do conhecimento, sendo os dados analisados a partir da análise de conteúdo, da qual emergiram as categorias: (I) Temáticas da formação, (II) Tipos de Formação e (III) Relação Universidade-Escola. As temáticas emergiram a partir do processo de análise das pesquisas, no qual resultou um total de quinze subcategorias, dentre elas: ensino de Ciências, TIC, prática docente e saberes docentes que percebemos como as mais relevantes à discussão. Com relação aos tipos de formação, verificamos: Curso de curta duração e Curso de longa duração. Já sobre a relação UE, emergiram quatro subcategorias. Assim, destacamos a importância da formação continuada de professores de Ciências pela interação UE, bem como a defesa de que as tecnologias e que a investigação-formação-ação (IFA) podem ser parte do caminho que favorecem este processo.
ИССЛЕДОВАНИЕ ЭЛЕКТРИЧЕСКИХ ХАРАКТЕРИСТИК МЕМРИСТОРНЫХ СТРУКТУР НА ОСНОВЕ НИТРИДА КРЕМНИЯ, "Электронная техника. Серия 3. Микроэлектроника"
Authors: Красников Г.Я. , Горнев Е.С. , Мизгинов Д.С.
Published: October 2022

В статье проведено исследование времени хранения заряда в мемристоре на основе SiN. Определены профиль распределения ловушек в запрещенной зоне SiN, их энергия и концентрация.
Monolithic Integrated Flexible Yet Robust Droplet‐Based Electricity Generator
Authors: Wang Lili , Li Wanbo , Song Yuxin , Xu Wanghuai , Jin Yuankai , Zhang Chao , Wang Zuankai
Published: October 2022

Developing robust technologies to harvest energy from ambient environments is critical to applications in self‐powered electronics. As a promising candidate, droplet‐based electricity generators with transistor‐inspired architecture, which consist of electrodes and dielectric material, have manifested superior capacity to gain sustainable energy from water. Despite extensive achievement, these devices are significantly limited by insufficient flexibility and unstable performance owing to the presence of inevitable mechanical abrasion, chemical corrosion, and interfacial detachment of electrode and dielectric material. Here, a facile approach is reported to construct a monolithic integrated droplet‐based electricity generator (MI‐DEG) device that enables high flexibility and robust electrical performance. The key to such flexibility and robustness of the MI‐DEG device lies in the meticulous utilization of a thermal fusion strategy that makes specially‐designed polymer electrodes and dielectric material seamlessly integrated together. It is demonstrated that MI‐DEG exhibits stable electrical output with negligible attenuation under long‐term mechanical deformation and abrasion, as well as retains over 60% of initial electrical output under harsh corrosive environments, as opposed to the complete failure of conventional counterpart. This study provides a hopeful pathway for the rational design of flexible and robust electricity generator, making it a step closer in the practical applications.
Noise Spectroscopy of Transport and Ion‐Related Phenomena in Silicon Nanowire Field‐Effect Transistor Biosensors
Authors: Guo Yangyan , Pustovyi Denys , Kutovyi Yurii , Boichuk Nazarii , Petrychuk Mykhailo , Zhang Yongqiang , Vitusevich Svetlana
Published: October 2022

High‐quality, liquid‐gated two‐layer (TL) nanowire (NW) field‐effect transistor (FET) structures are fabricated and studied in different operation regimes and with different concentrations of MgCl2 solutions. The space‐charge‐limited current (SCLC) effect is sensitive to surface phenomena and is registered at the drain‐source voltage (VDS) above 0.14 V, and analyzed using several methods including noise spectroscopy. Noise spectra reflect the clear transformation from 1/f to 1/ (f in power 1.5) behavior, confirming the SCLC effect, which is sensitive to ion processes at the NW FET surface. Moreover, the dimensionless Hooge parameters, measured at a level of 10−3, reflect the high quality of the fabricated devices and demonstrate the suppression of noise with VDS increasing up to 0.48 V. Such behavior additionally confirms the SCLC effect in the NW channel. The effect of suppression is stronger for small concentrations of MgCl2 solutions. The results should be taken into account for the detection of very small signals in biochemical solutions.
pH‐Responsive Motors and their Interaction with RAW 264.7 Macrophages
Authors: Ramos Docampo Miguel A. , Qian Xiaomin , Ade Carina , Floriano Marcelino Thaís , Ceccato Marcel , Foss Morten , Hovorka Ondrej , Städler Brigitte
Published: October 2022

Nano/micromotors are self‐propelled particles that use external stimuli to gain locomotion outperforming Brownian motion. Here, three different polymers are employed that are conjugated to silica particles through a pH‐labile linker. At slightly acidic pH, the linkers hydrolyze and release the polymeric chains, resulting in enhanced locomotion. The motors show a maximum velocity of ≈3 µm s−1 in cell media when poly(ethylene glycol) methyl ether methacrylate is asymmetrically distributed on the surface of the particles. Further, the motor internalization by RAW 264.7 macrophages was compared between motors, which have the polymer conjugated via a pH‐labile linker, and the irresponsive particles. Preliminary data indicate enhanced uptake, but further efforts are required to use responsive polymers to propel motors inside mammalian cells.
Trans‐Synaptic Degeneration Following Acute Optic Neuritis in Multiple Sclerosis
Authors: Murphy Olwen C. , Sotirchos Elias S. , Kalaitzidis Grigorios , Vasileiou Elena , Ehrhardt Henrik , Lambe Jeffrey , Kwakyi Ohemaa , Nguyen James , Zambriczki Lee Alexandra , Button Julia , Dewey Blake E. , Newsome Scott D. , Mowry Ellen M. , Fitzgerald Kathryn C. , Prince Jerry L. , Calabresi Peter A. , Saidha Shiv
Published: October 2022

Objective

To explore longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis (AON) in people with multiple sclerosis (PwMS), to investigate the process of trans‐synaptic degeneration, and determine its clinical relevance.

Methods

PwMS were recruited within 40 days of AON onset (n = 49), and underwent baseline retinal optical coherence tomography and brain magnetic resonance imaging followed by longitudinal tracking for up to 5 years. A comparator cohort of PwMS without a recent episode of AON were similarly tracked (n = 73). Mixed‐effects linear regression models were used.

Results

Accelerated atrophy of the occipital gray matter (GM), calcarine GM, and thalamus was seen in the AON cohort, as compared with the non‐AON cohort (−0.76% vs −0.22% per year [p = 0.01] for occipital GM, −1.83% vs −0.32% per year [p = 0.008] for calcarine GM, −1.17% vs −0.67% per year [p = 0.02] for thalamus), whereas rates of whole‐brain, cortical GM, non‐occipital cortical GM atrophy, and T2 lesion accumulation did not differ significantly between the cohorts. In the AON cohort, greater AON‐induced reduction in ganglion cell+inner plexiform layer thickness over the first year was associated with faster rates of whole‐brain (r = 0.32, p = 0.04), white matter (r = 0.32, p = 0.04), and thalamic (r = 0.36, p = 0.02) atrophy over the study period. Significant relationships were identified between faster atrophy of the subcortical GM and thalamus, with worse visual function outcomes after AON.

Interpretation

These results provide in‐vivo evidence for anterograde trans‐synaptic degeneration following AON in PwMS, and suggest that trans‐synaptic degeneration may be related to clinically‐relevant visual outcomes. ANN NEUROL 2023;93:76–87
Small Amphiphile‐Based Coacervation
Authors: Xiao Xiao , Jia Liyan , Huang Jianbin , Lin Yiyang , Qiao Yan
Published: October 2022

Coacervation plays an important role in the molecular assembly towards soft materials with a diversity of function (e. g., underwater adhesives of mussels and membraneless organelles). Coacervation is observed when one homogenous solution spontaneously separates into two immiscible liquid phases of low and high solute concentration, also known as liquid‐liquid phase separation (LLPS), which enables spatiotemporally local concentration of specific molecules. LLPS is a common physical phenomenon in aqueous solutions of polyelectrolytes, surfactants and biomolecules, which has been extensively explored for applications in the fields of environmental remediation, cosmetic formulation, protein purification, extractive fermentation and pharmaceutical microencapsulation. This review summarizes the development of LLPS with low molecular weight amphiphiles to construct simple and complex coacervates using conventional surfactants and novel amphiphiles such as azobenzene‐derivatives and peptides. We also highlight the applications of these amphiphile coacervates in the extraction of biomolecules, construction of protocell models and drug delivery.
Fast Magnesium Conducting Electrospun Solid Polymer Electrolyte
Authors: Walke Patrick , Venturini Janio , Spranger Robert J. , van Wüllen Leo , Nilges Tom
Published: October 2022

Magnesium Ion based Solid State Batteries (MIBs) are subject of intensive studies due to abundance of magnesium, its advantages in volumetric capacity, and the reduced dendrite growth. Here we report on a true solid polymer electrolyte system without liquid additives or plasticizers that reaches conductivities above 10−5 S cm−1 at room temperature and above 10−4 S cm−1 at 50 °C. An electrospun polymer electrolyte membrane fabricated from a polymer electrolyte featuring a composition of PEO : Mg(TFSI)2 36 : 1 [where PEO stands for poly(ethyleneoxide) and Mg(TFSI)2 for magnesium bis(trifluoromethanesulfonyl) imide] was identified as the best performing system. Magnesium transport was substantiated by different methods, and the electrochemical properties including solid electrolyte interface (SEI) formation were investigated. Electrospinning as a preparation method has been identified as a powerful tool to enhance the electrochemical properties beyond conventional polymer membrane fabrication techniques.
The perceived impact of counselling training on students' personal relationships
Authors: Daldorph Amy , Hill Suzannah
Published: October 2022

Background

Despite the urban myth of “the divorce course,” there is little research to support this perception of counselling training programmes. Studies exploring the lived experiences of counsellors in training have referred to relationship changes, but none have made these their primary focus. Research is needed to enhance our understanding of this formative stage for counsellors.

Aims

The purpose of this ideographic study is to gain new perspectives on the perceived impact of counselling training on trainees' personal relationships by exploring the lived experiences of five counsellors who completed their training in the last 18 months.

Method

Through a process of volunteer and snowball sampling, qualified counsellors were invited to participate in individual semistructured interviews, which were recorded and transcribed. Due to the small sample size and the emphasis on how each participant made meaning of their own experience, interpretative phenomenological analysis was chosen to interpret the findings.

Findings

Detailed analysis and interpretation of the data filtered into two superordinate themes:

permission to change; and

the challenge of integration.

Conclusion

The data revealed that training had a significant multifaceted impact on the personal relationships of all participants. Participants' experience of their training group and of personal therapy was found to be an important factor in this change, as were themes of agency and identity. The majority of ruptures in extant relationships took place early in training. Further research is needed, perhaps into the experiences of loved ones in relationships with student counsellors.
Multi‐exon COL5A1 deletion in a child with classical Ehlers–Danlos syndrome: A case report expanding the allelic spectrum and showing evidence of parental gonosomal mosaicism
Authors: Strang‐Karlsson Sonja , Keigwin Sylvia , Anttonen Anna‐Kaisa , Baker Duncan , Bean Kerry , Jakkula Eveliina
Published: October 2022

Classical Ehlers–Danlos syndrome (cEDS) is a rare inherited autosomal dominant connective tissue disorder with core clinical features including skin hyperextensibility, abnormal scarring, and generalized joint hypermobility. Classical EDS is predominantly caused by small pathogenic variants in the genes COL5A1 and COL5A2 and occasionally by a COL1A1 point mutation p.(Arg312Cys), while gross deletions or duplications are uncommon. Gonosomal mosaicism is thought to be exceedingly rare with only two cases reported in the literature. We report a child with cEDS due to a rare gross deletion of exons 2–65 in the COL5A1 gene, inherited from an unaffected mosaic father. The level of mosaicism in the father was approximately 43% in leucocyte cells and 30% in DNA extracted from skin. Our results expand the allelic spectrum of cEDS variants and suggest that parental mosaicism needs to be considered in patients with suspected cEDS, given its implication for genetic counseling.
Cu‐Co/ZnAl2O4 Catalysts for CO Conversion to Higher Alcohols Synthesized from Co‐Precipitated Hydrotalcite Precursors
Authors: Mockenhaupt Benjamin , Özcan Fatih , Dalebout Remco , Mangelsen Sebastian , Machowski Thomas , de Jongh Petra E. , Behrens Malte
Published: October 2022

The role of Cu:Co composition in bi‐metallic Cu‐Co/ZnAl2O4 catalysts on higher alcohol synthesis (HAS) was investigated at H2:CO = 4. The addition of Cu strongly facilitated Co reduction upon catalyst activation and suppressed coke deposition during HAS. Formation of predominantly hydrocarbons and higher alcohols was observed on the bi‐metallic catalysts. Co/ZnAl2O4 produced mainly CH4 and Cu/ZnAl2O4 mainly CH3OH, while at Cu:Co = 0.6 the best ethanol selectivity of 4.5 % was reached. The microstructure of the spent catalysts confirmed a close interaction of Cu and Co.
PROTOCOL: Measuring diet‐related consumer behaviours relevant to low‐ and middle‐income countries to advance food systems research: An evidence and gap map
Authors: de Jager Ilse , Harrison Megan , Wit Renate F. , Sonneveld Anne , Hesen Rosil , Uyar Betül T. M. , Verger Eric O. , Ramos Ana Islas , Vargas Melissa , Wijesinha‐Bettoni Ramani , Hachem Fatima , Brouwer Inge D.
Published: October 2022

This is the protocol for a evidence and gap map. The main objective of this evidence and gap map is to provide access to a systematic overview of available indicators for diet‐related consumer behaviours relevant to LMICs, to support policy makers and researchers to develop, monitor and revise food policies and programmes to leverage food systems transformations for healthier and more sustainable diets.
What enhanced recovery means for patients with cancer undergoing surgery
Authors: Lyu Heather G. , Raut Chandrajit P.
Published: October 2022

Enhanced recovery after surgery pathways may have a significant long‐term impact on oncologic‐specific outcomes for patients with cancer undergoing surgery.
Vinylpyrimidine‐Functionalized Triphenylamines: Bimodal Molecular Switches and Multilevel Systems
Authors: Alévêque Olivier , Achelle Sylvain , Sanguinet Lionel
Published: October 2022

Due to their numerous potential applications, the interest for the elaboration of new molecular switch has never stop to grow. Among them, multi‐modal systems, where the switching between two different metastable states can be induced by using indifferently several kinds of stimulation, have a special place. In this study, we present our efforts to develop a class of multi‐modal systems based on the association of a triphenylamine core with vinylpyrimidine units that exhibits nice acido and electrochromic properties. The most performant ones can present up to three different forms allowing to modulate their absorption and luminescence properties over three discrete levels. In order to provide limitations and outlooks for such systems, their switching behaviors have been rationalized by the help of DFT and TD‐DFT calculations.
Taste‐Associative Learning in Rats: Conditioned Immunosuppression with Cyclosporine A to Study the Neuro‐Immune Network
Authors: Leisengang Stephan , Schedlowski Manfred , Hadamitzky Martin , Lückemann Laura
Published: October 2022

The pharmacological effects of an immunosuppressive drug, such as cyclosporine A (CsA), can be learned and retrieved by humans and animals when applying associative learning paradigms. This principle is based on Pavlovian conditioning, in which repeated presentation of an “unconditioned stimulus” (US; here, the drug CsA) is paired with exposure to a “conditioned stimulus” (CS; here, the novel taste of saccharin). Re‐exposure to the CS at a later time leads to an avoidance behavior. Concomitantly, using this paradigm, animals exposed to the CS (saccharin) display immunosuppression, reflected by reduced splenic T‐cell proliferation and diminished interleukin‐2 and interferon‐γ expression and release in ex vivo cultured splenocytes, mimicking the pharmacological effects of the US (CsA). Notably, this paradigm of taste‐immune associative learning demonstrates the impressive abilities of the brain to detect and store information about an organism's immunological status and to retrieve this information, thereby modulating immunological functions via endogenous pathways. Moreover, conditioned pharmacological effects, obtained by means of associative learning, have been successfully implemented as controlled drug‐dose reduction strategies as a supportive treatment option to optimize pharmacological treatment effects for patients’ benefit. However, our knowledge about the underlying neurobiological and immunological mechanisms mediating such learned immunomodulatory effects is still limited. A reliable animal model of taste‐immune associative learning can provide novel insights into peripheral and central nervous processes. In this article, we describe protocols that focus on the basic taste‐immune associative learning paradigm with CsA and saccharin in rats, where conditioned peripheral immunosuppression is determined in ex vivo cultured splenocytes. The behavioral protocol is reliable and adaptable and may pave the road for future studies using taste‐immune associative learning paradigms to gain deeper insight into brain‐to‐immune‐system communication. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.

Basic Protocol 1: Taste‐immune associative learning with cyclosporine A

Basic Protocol 2: Splenocyte isolation and cultivation to study stimulation‐induced cytokine production
Quantum dot on a plasma‐facing microparticle surface: Requirement on thermal contact for optical charge measurement
Authors: Pustylnik Mikhail
Published: October 2022

Semiconductor nanocrystals, quantum dots (QDs), are known to exhibit the quantum‐confined Stark effect which reveals itself in the shift of their photoluminescence spectra in response to the external electric field. It was, therefore, proposed to use QDs deposited on the microparticle surface for the optical measurement of the charge acquired by the microparticles in low‐temperature plasmas. Another physical process leading to the shift of the photoluminescence spectra of the QDs is heating. Charging of plasma‐facing surfaces is always accompanied by their heating. Thermal balance of a quantum dot residing on the surface of a microparticle immersed in a plasma is considered in this work. It is shown that under periodically pulsed plasma conditions, the spectral shift of the photoluminescence of the quantum dot caused by the oscillations of its temperature becomes undetectable if the effective thermal flux characterizing the thermal contact between the quantum dot and the microparticle exceeds the value ranging from to depending on the plasma parameters. If this effective thermal flux exceeds the above‐mentioned values, the entire spectral shift observed during the period of plasma pulsing should be attributed to the quantum‐confined Stark effect due to the microparticle charge. Lower‐boundary estimate for the effective thermal flux for the direct contact between the quantum dot and the microparticle is . Estimations based on the heat conductivity of ligand‐stabilized nanocrystal arrays yield even higher values of the effective thermal flux .