bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Strategy for Developing Beef Cattle Production on a Smallholder Farming Basis in Musi Banyuasin Regency South Sumatra
Authors: Susanti Aulia Evi , - Rudy Priyanto , - Muladno - , Astuti Dewi Apri , Nugrohowati Lucia Cyrilla Eko
Published: November 2022

The increased beef cattle production at traditional farms is a strategy to achieve meat self-sufficiency in 2026. This is accomplished through various parties, including the government, academics, researchers, the private sector, and farmers as the main actors. Therefore, this study aimed to determine and analyze criteria, performance criteria, strategies, and alternatives for sustainable beef cattle production in traditional farms based on the opinion of experts. The research location was School for Smallholder Community (SPR) Maju Bersama, Sungai Lilin Sub-District, Musi Banyuasin Regency, South Sumatra Province, Indonesia. Primary data were collected through FGD (focus group discussion) and interview with expert stakeholders, including farmers, policymakers, entrepreneurs, academics, and research analyst. They were analyzed using the Analytical Hierarchy Process (AHP) with R studio version 4.1.2. The result showed that Musi Banyuasin Regency has a natural resource potential for supporting beef cattle production with an institutional collaborative strategy. The interaction between the production factors showed that the feeding criteria were at the highest level, with 32.05%. Considering the performance criteria, business sustainability was essential at 35.70% and should be achieved by adopting a corporate strategy of 85.52%, implemented through alternative business management at 61.40%.
Bio-processing Plantation by-products with White Oyster Mushroom (Pleurotus ostreatus) to Improve Fermentability and Digestibility Based on Substrate Type and Fermentation Time
Authors: Azzahra Yulia Riska , Toharmat Toto , Prihantoro Iwan
Published: November 2022

Plantation by-products can be used as livestock feed with proper processing, optimizing the feed efficiency of palm kernel cake (PKC), empty oil palm bunch (EOPB), and acacia sawdust (AS). This study aimed to improve the usability of the byproducts as alternative feed through the Pleurotus ostreatus fermentation process. To this end, a 3×3 factorial, completely randomized design was applied. Factor A was the type of substrate, P1 = PKC, P2 = EOFB and P3 = AS. Factor B was the fermentation period, T1 = 0 d, T2 = 30 d and T3 = 60 d. The collected data were analyzed using analysis of variance (ANOVA), and the significantly different result was further tested using Duncan Test. The observed variables include Neutral Detergent Fiber (NDF), acid detergent fiber (ADF), hemicellulose, pH value, dry matter digestibility (DMD), organic matter digestibility (OMD), N-NH 3 , and volatile fatty acids (VFA). The study result showed that P.ostreatus mushroom in various substrate types did not significantly affect the fiber fraction of NDF, ADF, and Hemicellulose. This study also found that the interaction of substrate type and fermentation duration significantly affects dry matter digestibility, organic matter digestibility, N-NH 3 production, and VFA values. This study concluded P. ostreotus increased the nutritional value and digestibility of the by- product from plantation processing. The best fermentation duration was 60 d PKC was found to have the highest digestibility value, and the best interaction was found in PKC with 60 d of fermentation.
Blood Profile and Carcass Production of Broiler Chickens Given Nucleotides and Turmeric Extract in Feed
Authors: Aldiyanti Amani , Tugiyanti Elly , Hartoyo Bambang
Published: November 2022

Broiler chickens are birds that grow very fast, but have low body resistance and are easily stressed. This study aimed to examine the effect of nucleotide and turmeric extract (Curcuma longa Linn) on blood profile (erythrocytes, hemoglobin and leukocytes) and carcass production (weight of carcass, weight of breast, thighs and wings) in broiler chickens. Data was collected using a completely randomized design with 7 treatments consisting of Control: basal feed + antibiotic Bacitracin Zinc 0.1 g/day; N 0 : basal feed; N 1 : basal feed + turmeric extract 600 mg/kg feed; N 2 : basal feed + nucleotide 250 mg/kg feed; N 3 : basal feed + nucleotide 250 mg/kg feed + turmeric extract 600 mg/kg feed; N 4 : basal feed + nucleotide 500 mg/kg feed; N 5 : basal feed + nucleotide 500 mg/kg feed + turmeric extract 600 mg/kg feed. The results showed that nucleotide supplementation and turmeric extract had no significant effect on weight of carcass, weight of breast, thighs and wings, hemoglobin, erythrocytes and leukocytes of broiler. The use of nucleotide and turmeric extract could not improve the blood profile of broiler.
Polymorphisms KIF12 GENE|BfaI and its Association on Carcass Characteristics and Lamb Meat Quality
Authors: Ekawati Raudah Putri , Harahap Ratna Sholatia , Listyarini Kasita , Sumantri Cece , Gunawan Asep
Published: November 2022

One of gene which involves on mediation an antioxidant cascade in beta cells as an intracellular target of excess fat intake is Kinesin Family 12 (KIF12). This study aims to identify the diversity of SNP g. 9617965 C>T KIF12 and association with carcass characteristic and meat quality. The total sample used were 102 ram DNA samples consisted of 10 barbados cross sheep (BCS), 52 javanese thin tail (JTT), 15 jonggol sheep (JS), 15 garut sheep (GS), and 10 compass agrinak sheep (CAS). Identification of the diversity of KIF12|BfaI was conducted using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The results showed that the amplification product was 696 bp. The diversity of the KIF12 gene was found three genotypes namely CC, CT, and TT. The allele frequency in all types of sheep was in Hardy-Weinberg equilibrium. A SNP of the KIF12 was associated (P<0.05) with characteristic of carcass, including length of carcass. The association of KIF12 with meat quality was significant (P<0.05) too associated with pH and water holding capasity (WHC). It could be concluded that KIF12 gene is a potential candidate gene for carcass characteristic and meat quality traits in sheep
Gelatinase Microbial Morphology from Leather Defect
Authors: Kurniawati Novita , Erwanto Yuny , Bachrudin Zaenal , Pertiwiningrum Ambar
Published: November 2022

Microbes attach in pickle leather, wet blue leather, and upper shoeleather have been identified to have positive profile to produce extracellular protease enzymes with pH values of acidic to basic on 15% gelatin and 2% commercial skimmed milk as substrates. Defective tanned leather was added to a microbial growth solution enriched with 2% gelatin substrate and incubated for 7 days at room temperature on an open rotary shaker at 120 rpm and then stored at room temperature while waiting for gelatinase testing. There were 5 morphological colonies of microbial gelatinase from defective tanned skin, all of which were white.
Effect of Fault Slip on the Casing Passability of Horizontal Shale Oil and Gas Wells
Authors: Hu Gang , Deng Shengyi , Wang Dong
Published: November 2022

Fault slip, a secondary effect of the hydrofracture to extract shale oil and gas, deforms the casing locally and affects downhole tools going through it, hindering the exploitation plan. The casing passability is introduced to evaluate the casing passability for the downhole tool. A simulation model of the fault slip was established to analyze the effect of fault type, slip distance, and fault dip on the casing passability. Meanwhile, the simulation method adopted in this paper was verified by the large-scale physical experiments of the perforated casing subjected to uniform outer pressure. Based on the experimental results and the geometry of fault slip, an empirical formula is proposed for the relationship between casing passability and fault slip. The result shows that the sensitivity of casing passability affected by fault type is ranked from highest to lowest by strike-slip fault, normal fault, and reverse fault. This study provides a reference for determining the available diameter of downhole tools quickly and reduces the cost of exploring wells when downhole tools are obstructed.
Investigation of Virulence and Antibiotic Resistance Genes of E. Coli Strains Isolated from Duhok Hospital by Bacteriological and Molecular Methods
Authors: qader marwan khalil , khalid haval mohammed
Published: November 2022

Background
The existence of different subsets related to virulence-associated genes in specific path types that are lacking in commensal isolates explains the wide range of pathogenic characteristics and clinical symptoms induced through E. coli path
Amis
: Using PCR-method to investigate E. coli phylogenetic analysis. Detecting the prevalence related to virulence and antibiotic resistance genes in E. coli, as well as their distribution within phylogenetic groupings.
Methods
365 E. coli UTI infection isolates were collected from clinical cases from three major hospitals in Duhok -Iraq.Two hundred and five (56.16%) isolated from male patients and 165 (43.83%) from female patients. One hundred isolates were extracted with a commercial kit, with an average of the concentration of genomic DNA extracted using the commercial kit at 115.25ng/µl with a purity of 1.8.
Results
to confirm that the genome of all isolates is E. coli, all strains with a molecular weight of approximately 657 bp were successfully amplified producing a single band of uidA as the species-specific gene. The results revealed that Pai and hyl genes related to virulence and antibiotic resistance were absent from any of the tested markers in 10 (28%) of these isolates. As a marker for the presence of a pathogenicity island, the Pai gene is the most dominant marker among all other virulence markers with 75%, followed by the hyl gene with 69 percent.
Conclusion
There may be a spill of information for the resistance circumstance exterior the clinic environment, particularly for the predominance of multiresistant microbes in solid individuals
A stochastic agent-based model to evaluate COVID-19 transmission influenced by human mobility
Authors: Chen Kejie , Jiang Xiaomo , Li Yanqing , Zhou Rongxin
Published: November 2022

The COVID-19 pandemic has created an urgent need for mathematical models that can project epidemic trends and evaluate the effectiveness of mitigation strategies. To forecast the transmission of COVID-19, a major challenge is the accurate assessment of the multi-scale human mobility and how they impact the infection through close contacts. By combining the stochastic agent-based modeling strategy and hierarchical structures of spatial containers corresponding to the notion of places in geography, this study proposes a novel model, Mob-Cov, to study the impact of human traveling behaviour and individual health conditions on the disease outbreak and the probability of zero COVID in the population. Specifically, individuals perform power-law type of local movements within a container and global transport between different-level containers. Frequent long movements inside a small-level container (e.g. a road or a county) and a small population size reduce the local crowdedness of people and the disease infection and transmission. In contrast, travels between large-level containers (e.g. cities and nations) facilitate global disease spread and outbreak. Moreover, dynamic infection and recovery in the population are able to drive the bifurcation of the system to a "zero-COVID" state or a "live with COVID" state, depending on the mobility patterns, population number and health conditions. Reducing total population and local people accumulation as well as restricting global travels help achieve zero-COVID. In summary, the Mob-Cov model considers more realistic human mobility in a wide range of spatial scales, and has been designed with equal emphasis on performance, low simulation cost, accuracy, ease of use and flexibility. It is a useful tool for researchers and politicians to investigate the pandemic dynamics and plan actions against the disease.
The effects of heading time on yield performance and HvGAMYB expression in spring barley subjected to drought
Authors: Ogrodowicz Piotr , Kuczyńska Anetta , Krajewski Paweł , Kempa Michał
Published: November 2022

In the lifetime of a plant, flowering is not only an essential part of the reproductive process but also a critical developmental stage that can be vulnerable to environmental stresses. To ensure survival during drought, plants accelerate the flowering process, and this response is known as „drought escape”.HvGAMYB– transcriptional factor associated, among others, with flowering process and anther development in barley has also an important role in developmental modification and yield performance in plants subjected to stressed conditions. However, there is limited information whether the mechanisms associated with the flowering acceleration may cause the anther or pollen disruption due to their influence on flower developmentvia GAMYBoverexpression. The aim of this study was to characterize differences in responses to drought among barley genotypes varied in terms of earliness. Two subgroups of barley plants differentiated in terms of phenology were analyzed, and a wide range of traits linked to plant morphology, physiology, and yield were investigated. The abiotic stress reactions of two barley plants subgroups varied in our study both in terms of yield, morphology, chlorophyll fluorescence kinetics and pollen viability. The results extend our knowledge aboutHvGAMYBexpression in anthers of barley plants grown under drought conditions and indicate the role of this transcription factor in shaping the yieldviainfluencing traits linked to spike morphology, especially in lateral stems. Hence, this gene could be regarded as an important factor in flowering process and, as a consequence, pollen and seed development in plants subjected to abiotic stress conditions. This study clearly show the important role ofHvGAMYBin survival mechanism associated with so called “drought escape strategy”.
The Moderating Role of Family Social Capital in the Relationship between Community Social Capital and Life Satisfaction among Older Adults in Northeast Rural China
Authors: Zhang Jingyue , Lu Nan
Published: November 2022

Background: This study examined the moderating effect of family social capital on the relationship between community social capital and life satisfaction among rural community-dwelling older adults in Northeast China.
Methods: Data were based on a social survey in the rural communities of Northeast China in late 2019. The analytic model included 455 respondents who completed the survey successfully. We used multiple-group analysis to test the proposed hypotheses.
Results: The results show that family social capital played a significant moderating role in the relationship between community social capital and life satisfaction. In other words, both cognitive social capital and social participation were significantly associated with life satisfaction in the higher family social capital group, whereas these associations were not significant among those with relatively lower levels of family social capital.
Conclusions: The future development of social capital policies and interventions should focus on not only the promotion of cognitive social capital and social participation among rural community-dwelling older adults, but also the social needs of older rural Chinese adults with low family social capital.
Morpho-anatomical and Phylogenetic studies of Russula species from Narkanda, India
Authors: Kaur Munruchi , Kaur Amandeep , Wani Naseema Aqbar
Published: November 2022

Background
The genus Russula is considered one of the most abundant and widely distributed ectomycorrhizal agaric genera and the Indian subcontinent is no exception to it. The members of this family are cosmopolitan and form an ectomycorrhizal association with a wide range of angiosperm and gymnosperm trees.
Methods and Results
Four new records of genus Russula viz., Russula pauriensis var. caulocystidii var. nov., Russula globispora, Russula cuprea and Russula laeta were collected from Narkanda, Himachal Pardesh, India. These were described and illustrated on the basis of morpho-anatomical characters as well as phylogentic analysis of internal transcribed spacer (ITS) ribosomal DNA sequences. On the basis of gross taxonomic characterization Russula pauriensis var. caulocystidii var. nov. is proposed which is further confirmed through molecular taxonomy. Russula laeta, Russula globispora, Russula cuprea and Russula laeta is reported for the first time from India while Russula amethystina is a rereport.
Conclusion
Current environmental challenges of global warming and climate change will affect the regeneration and growth patterns of delicate fungi that require specific microclimate. Present study is a step towards deciphering macrofungal diversity, especially in the biodiversity-rich forests of Narkanda, to enable diversity planning, management and conservation.
A novel hsa_circ_0006903 promotes tumor development and dendritic cells activated expression in infantile hemangioma
Authors: Gao Xibo , Chen Lixin , Zuo Hailiang , Li Qinfeng
Published: November 2022

Background: Increasing studies revealed that circular RNAs (circRNAs) and immune cell infiltration were associated with tumor development. However, its role in infantile hemangioma (IH) remains unclear. This study will explore a novel circRNA hsa_circ_0006903-based ceRNA network and validate dendritic cells activated expression in IH.
Methods: Differentially expressed circRNAs(DECs) were identified from Gene Expression Omnibus (GEO) database. Regulatory networks and functional enrichment analysis were constructed. CIBERSORT was used to characterize immune cells composition. RT-qPCR was performed to detect the expression of hsa_circ_0006903 in cell lines. Then, the biological functions of hsa_circ_0006903 were validated in vitro using transwell assay. Immunofluorescence was applied to the colocalization of CD11b for dendritic cells activated as a biomarker in IH tissues.
Results: Using GEO database, a total of 67 DECs were identified in IH. Hsa_circ_0006903 was selected as the most significant DECs in this study. Then, a novel hsa_circ_0006903-ceRNA network was constructed. Mechanistically, functional enrichment analysis showed that the p53 signaling pathway played the most important roles, and hsa_circ_0006903/miR-6721-5p/CACNA2D2 and hsa_circ_0006903/miR-4786-3p/ATP13A4 axis were identified. We found that CACNA2D2, ATP13A4, and P53 were significantly downregulated in IH cell lines. In this study, we validated that dendritic cell activated was significantly overexpressed. Moreover, CD11b as a biomarker of dendritic cells activated were tested in IH tissues. Finally, hsa_circ_0006903 was significantly overexpressed, and hsa_circ_0006903 promoted infantile hemangioma cell proliferation, invasion, and migration in vitro.
Conclusion: We revealed a novel hsa_circ_0006903-mediated ceRNA network and explored the landscape of immune cells infiltration, especially CD11b overexpression as a biomarker of dendritic cells activated in IH.
Dietary supplementation with xylooligosaccharides and exogenous enzyme improved milk production, energy utilization efficiency and reduced enteric methane emissions of Jersey cows
Authors: Dong Lifeng , Zhao Lei , Li Bowei , Gao Yanhua , Yan Tianhai , Lund Peter , Liu Zhuofan , Diao Qiyu
Published: November 2022

Background
Sustainable strategies for enteric methane (CH4) mitigation of dairy cows have been extensively explored to improve production performance and alleviate environmental pressure. The present study aimed to investigate the effects of dietary xylooligosaccharides (XOS) and exogenous enzyme (EXE) supplementation on milk production, nutrient digestibility, enteric CH4 emissions, energy utilization efficiency of lactating Jersey dairy cows. Forty-eight lactating cows were randomly assigned to one of 4 treatments with a 2 ×2 factorial arrangement of treatments: (1) control diet (CON), (2) CON with 25 g/d XOS (XOS), (3) CON with 15 g/d EXE (EXE), and (4) CON with 25 g/d XOS and 15 g/d EXE (XOS + EXE). The 60 d experimental period consisted of a 14-d adaptation period and a 46-d sampling period. The enteric CO2 and CH4 emissions and O2 consumption were measured using the GreenFeed system, which were further used to determine the energy utilization efficiency of cows.
Results
Compared with CON, XOS and EXE synergistically (P < 0.05) increased milk yield, fat concentration, and energy-corrected milk yield (ECM)/DM intake, which could be reflected by the significant improvement (P < 0.05) of dietary NDF and NDF digestibility. The gaseous results showed that XOS and EXE synergistically (P < 0.05) reduced CH4 emission and CH4 emissions intensities (e.g., CH4/DM intake, CH4/milk yield, and CH4/ECM yield), whereas CO2 emission and O2 consumption remained similar among the treatments (P > 0.05). Furthermore, the synergistic effects of XOS and EXE was observed (P < 0.05) for metabolizable energy intake and CH4 energy output as a proportion of gross energy intake, whereas lowest values (P < 0.05) of CH4 energy output and CH4 energy output as a proportion of gross energy intake was observed for cows fed XOS compared with the remaining treatments.
Conclusions
Dietary supplementary of XOS and EXE contributed to the improvement of lactation performance, nutrient digestibility, and energy utilization efficiency, as well as reduction of enteric CH4 emissions of lactating Jersey cows. More research is also needed to investigate the long-term effect and mode of action of these additives for Jersey cows.
WITHDRAWN: Integrated Reliability, Resilience and Sustainability Framework for Water Supply Systems Risk Management
Authors: Dweedar Sohaila , Mobasher Amir , Elashry Osama , Reda Mohamed
Published: November 2022

The water supply system (WSS) is usually collected from the water source, transmission pipes, treatment plants and water distribution networks to taps and usually exposed to various risks. However, this study provides a framework for WSS that provides drinkable water to various Cairo regions. The scope of work consisted of two main parts, at the first part, the methodology for risk management in Cairo water system will be adopted by assessment of common risks in water distribution systems (WDS), and these types of risks are classified depended on its effect on the reliability, resilience and sustainability. While, at the second part, Analytic Hierarchy Process (AHP) method is developed to incorporate risk alternatives mitigation based on supply reliability, resilience and sustainability. And therefore supply decision support on the choosing of risk response strategies according to the correspondence between their reference and comparability sequences. The results of this paper showed that several risks represent the main parameter that need to characterize water supply systems and their operations, The application of the frame work mentioned in this study will result in increasing the overall score of Al Amerya Water Treatment Plant (WTP) by 49%; moreover the score of Mostorud WTP will improve by 48%. Additionally, the study provided a base for water utilities to reduce the risk of disobedience and achieve desirable service standards in the short, medium and long term, So Water providers can apply this study framework to assist future evaluation.
Thermal and Dynamic Radiation in the THz range under Spin CurrentInjection in Magnetic Junctions
Authors: Chigarev S. G. , Fomin L. A. , Rai D. P. , Vilkov E. A. , Byshevsky-Konopko O. A. , Zagorsky D. L. , Doludenko I. M. , Panas A. I.
Published: November 2022

An experimental approach to the problem of the energy distribution of radiation in the THz range created by an electron flow passing through a magnetic junction between thermal and dynamic is considered. The experimental results obtained during the operation of a spin-injection emitter based on an array of heterogeneous magnetic nanowires confirmed the assumption about the "competition" of thermal and dynamic radiation processes.
Serum folate and homocysteine levels are associated with cardiometabolic risk factors in patients with type 2 diabetes
Authors: Men Xueyan , Yang Jin , Yan Yelan , Yue Peipei , Zhang Meng , Gong Li , Liu Shengyun
Published: November 2022

Background
Previous studies indicate that serum folate is inversely associated with metabolic syndrome (MetS). This study aims to investigate the association between serum folate, homocysteine (Hcy) levels, and cardiometabolic risk in patients with type 2 diabetes (T2D).
Methods
Associations between serum folate, Hcy levels, and cardiometabolic risk factors were assessed in a cross-sectional study of 755 participants with T2D.
Results
In individuals with MetS, the serum folate levels were significantly lower than in subjects without MetS, whereas the serum Hcy was significantly higher. Serum folate level was negatively correlated with CRP, body mass index (BMI), serum Hcy, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), serum uric acid (UA), and diastolic blood pressure (DBP) but positively correlated with high-density lipoprotein cholesterol (HDL-C). Furthermore, serum Hcy concentrations were positively correlated with BMI, UA, total cholesterol, TG, and LDL-C. A multiple linear regression analysis was used to identify predictors for cardiometabolic risk. Low serum folate levels were identified as an independent risk factor for obesity and dyslipidemia in patients with T2D. Moreover, high serum Hcy levels were positively associated with serum UA and hypertension after adjusting for potential confounders.
Conclusion
Low serum folate levels was an independent risk factor for obesity and dyslipidemia in the T2D population. High Hcy levels were positively associated with serum UA and hypertension.
A New Evaluation Method: Evaluation Data and Metrics for Chinese Grammatical Error Correction
Authors: Lin Nankai , Fu Yingwen , Lin Xiaotian , Yang Ziyu , Jiang Shengyi
Published: November 2022

As a fundamental task in natural language processing (NLP), Chinese Grammatical Error Correction (CGEC) [1–3] has gradually received widespread attention and become a research hotspot. However, one obvious deficiency of the existing CGEC evaluation systems is that the evaluation values of the same error correction models are signif- icantly influenced by the Chinese word segmentation (CWS) results or different language models. However, it is expected that these met- rics should be independent of the CWS results and language models for a fair evaluation. To this end, we propose three novel eval- uation metrics for CGEC in two dimensions: reference-based and reference-less. What’s more, according to these three evaluation met- rics, we build a new evaluation metric that can comprehensively evaluate the CGEC model from multiple dimensions. We deeply eval- uate and analyze the reasonableness and validity of the proposed metrics, and we expect them to become a new standard for CGEC.
Electron Spin Resonance Study of Magnetite Nanoparticles as a Magnetically Separated Catalyst for Epoxide Thiolysis
Authors: Yakushkin S. S. , Kirillov V. L. , Philippov A. A. , Martyanov O. N.
Published: November 2022

Catalytic systems based on the colloidal magnetite Fe3O4 nanoparticles were studied in the epoxide thiolysis reaction conditions and during the magnetic separation. Two samples of superparamagnetic Fe3O4 nanoparticles with the mean size of 4 nm and 10 nm were studied using electron paramagnetic resonance in situ, X-ray diffraction and electron microscopy. The role of the nanoparticles size for the magnetic separation effectiveness and catalytic effect in the epoxide thiolysis reaction has been demonstrated.
Low-Cost Defect Simulation Framework for Analog and Mixed Signal (AMS) Circuits with Enhanced Time-Efficiency
Authors: Saikiran Marampally , Sekyere Michael , Ganji Mona , Yang Ruohan , Chen Degang
Published: November 2022

Defect-oriented testing is becoming increasingly popular in recent times, especially in safety-critical applications in automotive, space and medical industries. The stringent quality requirements from these industries such as zero defective parts per million (DPPM) necessities a need to have efficient defect testing methods. Furthermore, the overall development time of integrated circuit can be reduced by reducing the defect simulation time. In this work, we present a simple and time-efficient defect simulation framework for pre-silicon testing of AMS circuits. In our method, a given defect model is realized using Verilog-A modules and tests multiple defects in a circuit in a single-run simulation. In contrast to the conventional defect simulation framework, our method saves simulation time by avoiding the repetitive work of generating a netlist for each defect and by reducing the time overhead for the simulator to interface with data/file-handling system. To strongly validate our proposed framework, we use diverse AMS circuits such as operational amplifier (op amp), fast transient flipped-voltage follower based low-dropout regulator (FVF LDO) and Successive-approximation-register (SAR) analog-to-digital converters (ADC). For DC testing schemes used for op amp and LDO testing, we show that our proposed framework reduces the simulation time to less than one-tenth (1/10th) in comparison with conventional framework. On the other hand, for the transient testing scheme, the proposed framework reduces the simulation time to less than 50% of the conventional framework. Furthermore, we also show that there is no negative impact on the defect coverage using the proposed framework.
Uniquely trigger the death of cancer cells by destruction of lysosomes
Authors: Du Ying-Ying , wang ying-pu , Xing En-Yun , Yin Juan-Juan , Jiang Xu , Wang Ning , Lin Yan-Xin , Shi Rui-Jie , Wang Ping , Xiao Xiang-Qian , Feng Ya-Qing , Meng Shu-Xian
Published: November 2022

In recent years, various anti-tumor treatment methods have emerged in endlessly. Here in, a novel anti-tumor mechanism is designed and a special double-layer nanoparticles (CMC/MgO @ FA-CS/BODIPY NPs) were prepared. It utilizes the special acidic environment of cell lysosomes to swell violently in lysosomes, destroy lysosomes and release hydrolases. Because the number of tumor cell lysosomes is significantly more than that of normal cells, and the volume is also larger, resulting in the release of a large number of hydrolases to digest the entire tumor cell and cause it to die, while the number of normal cell lysosomes is small, and the destruction of lysosomes is not enough to kill cell. In this paper, animal experiments and the control experiments of tumor cells and normal cells prove that the designed nanoparticles have a broad-spectrum antineoplastic activities and are harmless to normal cells. At the same time, the nanoparticles are mainly composed of carboxymethyl cellulose (CMC), chitosan (CS) and other commonly used pharmaceutical excipients, which have no toxicity. Therefore, this method is a new safe and effective way to treat tumors. It has not been reported in any literature.
Nursing undergraduates’ perception towards the flipped classroom of Operating Room Nursing Operation based on the HTML5 mobile micro-class: A qualitative study
Authors: Wu Fei , Chen Jie , Huang Xi , Mo Wenjuan , Hu Li , Li Xiaohan , Liao Li
Published: November 2022

Background: The flipped classroom (FC) is a blended teaching method based on digital resources. The traditional FC in the field of nursing practice teaching that relies on video micro-class to achieve the goal of flipped teaching has been confirmed effective. However, the video micro-class has few interactions with students,while the HTML5 mobile micro-class is theoretically more diverse and more interactive.For the time being, this statement lacks robust evidence from nursing undergraduates’ perception towards the FC of Operating Room Nursing Operation (ORNO) based on HTML5 mobile micro-class.
Purpose: To provide a basic reference for nursing educators to carry out flipped classroom in practical teaching, we deeply comprehend nursing undergraduates’ perception towards the ORNO-FC based on the HTML5 mobile micro-class.
Methods: An qualitative descriptive research method using semi-structured interviews were conducted among 17 students who participated in the ORNO-FC based on the HTML5 mobile micro-class by purposive sampling. Thematic analysis was conducted to analyze the data in order to identify themes in the interview transcripts.
Results: Analysis of the interview content revealed four primary themes along with sub-themes: (1) improvement in the learning state, (2) enhancement in the learning effect, (3) insufficiency of mobile micro-class production, and (4) insufficiency of teaching design.
Conclusion: Through the ORNO-FC based on HTML5 mobile micro-class can give back learning autonomy to students so that they can meet their own demands with personal style, boost the learning efficiency of students, inspire their interest in learning, improve their health physically and mentally, and significantly make the teaching atmosphere student-centered. However, the FC of practical teaching is not suitable for all operational projects; therefore, mobile micro-class should be combined with demonstrations by teachers for highly complex projects with many operational details and high degree of complexity.
Physical processes associated with summer rains in the western slope of the Peruvian Andes, using weather radar data and numerical modeling: case studies
Authors: Moya-Álvarez Aldo S. , Silva Yamina , Villalobos-Puma Elver , Saavedra-Huanca Miguel , Castillo Carlos Del , Kumar Shailendra
Published: November 2022

Rain in the city of Lima is unusual and difficult to predict, so it is of great interest to study the mechanisms that generate it when it exceeds normal limits. This work analyzes the synoptic and local circulation conditions that gave rise two precipitation events over the Rimac river basin, in order to characterize the physical processes related to those events. In the first case, the rain affected the city of Lima. In the investigation, surface precipitation measurements, weather radar and satellite information, as well as the WRF outputs were used. For the synoptic analysis, ERA5 reanalysis database were used. As a result, the role played by the humid Eastern Amazon flow was confirmed, but in this case, the important role played by the local circulation of sea daytime breezes and its interaction with Amazon flow, which determined the zone of formation of the largest precipitation areas, was detected. Associated with this interaction, the presence of gravity waves and their importance in strengthening cloud systems was observed. At the same time, it was detected that the daytime sea breeze does not change direction during the night, as it generally does, but it stays from the sea towards the land, although somewhat weaker. The weakening of the Eastern flow from the Amazon was observed to be related to the retreat to the east of the ridge of the South Atlantic Anticyclone. Also, the importance of anticyclonic circulation at high levels over the region was confirmed. At the same time, it was found that the WRF model acceptably describes the mechanisms of formation of this type of event and also adequately reflects the spatial distribution of the rains associated with them. In general, it underestimated the accumulated precipitation recorded by the rain gauge network in the region.
Constructing a Stratigraphic Knowledge Graph (StraKG) with Multi-source Data to Better Understand the Earth’s Rock Layers
Authors: Li Wenjia , Ma Xiaogang , Wang Xinqing , Wu Liang , Salati Sanaz , Xie Zhong
Published: November 2022

The strata formed in different geological time reflect diverse elements of the geosphere, biosphere, and atmosphere in the Earth’s history of evolution. Stratigraphy, thus, is able to provide a comprehensive understanding of the Earth's rock formations from many aspects, such as litho-stratigraphy, biostratigraphy, event-stratigraphy, and chrono-stratigraphy. In the past decades, massive geological survey data have been made open, which present invaluable resources for studying the stratigraphy in different regions and at different scales. However, many of the open datasets are recorded in the literal form with heterogeneous terminology and there is a shortage of efficient approaches to explore and analyze them. In this research, we designed and constructed a Stratigraphic Knowledge Graph (StraKG) to help address that challenge. StraKG has two layers: schema layer and instance layer. In the schema layer, we used community-recognized terminology from geological dictionaries. In the instance layer, we used natural language processing techniques to analyze open data and obtained relationships between strata and entities such as rocks and spatial locations. The records in the two layers were associated to establish a consistent structure of stratigraphic records in StraKG. To verify the functionality of the resulting knowledge graph, we applied it to the Baidu Encyclopedia, which the largest online Chinese encyclopedia and has heterogeneous labels of stratigraphic sections and massive records of stratigraphic descriptions. A list of three experiments were implemented on the topics of stratigraphic correlation, spatial distribution of a certain stratum, and spatio-temporal distribution of open stratum data. The results show that StraKG is able to provide a powerful reference for the quantitative study of stratigraphy. Used together with data exploration and data mining methods, StraKG illustrates a new approach to analyze the open and big literature data in geoscience.
Cannabidiol-loaded poly lactic-co-glycolic acid nanoparticles with improved bioavailability as a potential for osteoarthritis therapeutic
Authors: Jin Zhiqiang , Zhan Yanting , Zheng Li , Wei Qingjun , Xu Sheng , Qin Zainen
Published: November 2022

Cannabidiol (CBD) is a non-intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as a potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its clinical application. Here, we report an effective strategy to fabricate CBD-loaded poly lactic-co-glycolic acid nanoparticles (CBD-PLGA-NPs). The CBD-PLGA-NPs exhibited a spherical morphology and an average diameter of 238 nm. CBD was sustained release from CBD-PLGA-NPs, which improved the bioavailability of CBD. Primary chondrocytes from rat pups were isolated, and LPS was used to induce inflammation in vitro to simulate osteoarthritis (OA). The CBD-PLGA-NPs effectively protect the damage of LPS to cell viability. What’s more, according to the results of CCK-8 assay, hematoxylin-eosin staining, safranin O staining, immunofluorescence staining, and real-time polymerase chain reaction assay, we observed that CBD-PLGA-NPs significantly suppressed LPS-induced primary rat chondrocyte expression of inflammatory cytokines, including interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase 13 (MMP-13). Remarkably, CBD-PLGA-NPs also showed better therapeutic effects of inhibiting the degradation of the extracellular matrix of chondrocytes than equivalent CBD solution. In general, the fabrication CBD-PLGA-NPs showed good protection of primary chondrocytes in vitro and is a promising system for osteoarthritis treatment. Significance of the study Cannabidiol (CBD) is a non-intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as a potential drug for arthritis treatment. In order to improve the poor solubility and low bioavailability of CBD, we described the development of simple and efficient CBD-loaded nanoparticles (CBD-PLGA-NPs) for treating LPS-induced primary chondrocytes of rat pups damaged. The fabricated CBD-PLGA-NPs could effectively enhance the chondroprotective effects of CBD by inhibiting the expression of inflammatory factors, increasing cellularity, and improving structural changes, which can be regarded as a potential system to treat OA.
Effects of Unplanned Pregnancy on the Initiation of Intimate Partner Violence in Southeast Iran
Authors: Nejad Fateme Khajoei , Alidousti Katayoun , Bagheri Nahid
Published: November 2022

Background:Violence during pregnancy may lead to pregnancy complications or adverse birth outcomes or other serious reproductive events. Unplanned pregnancy can lead to a wide range of physical and psychological consequences for mother and child and affects different aspects­ of social, economic and cultural health. The aim of study is to find if unplanned pregnancy can cause intimate partner violence.
Methods: This cross-sectional descriptive research was carried out with available sampling on 300 eligible women (150 with unplanned pregnancy and 150 with planned pregnancy) who referred ­to health care centers in, Kerman, Iran in 2021. Iranian version of domestic violence questionnaire and spss­22 were used for data collection and analysis.
Results: The mean age, and age difference with spouse were 29.77±7.06 years, and 4.31±3.03 years respectively. The majority of women (28%) had a diploma, were housewives (69.65%). Comparing domestic violence in unplanned pregnancy group showed that the overall amount of violence during pregnancy (60.64±30.51) was higher than before pregnancy (51.83±25.02) and this difference was significant (p<0.05). the overall mean score of domestic violence in the group with unplanned pregnancy (60.64±30.51) is higher than the group with planned pregnancy (51.35±26.99) (p<0.05). we see that the difference in the mean score of the psychological dimension in unplanned pregnancy (14.23±6.03) and the group of planned pregnancy (10.57±5.32) is statistically significant (p<0.05). Also, the mean score of patriarchal beliefs in the group with unplanned pregnancy (36.93±20.58) during pregnancy is higher than the group with planned pregnancy (31.48±18.43) (p<0.05)
Conclusion: Results showed that all of the domestic violence which started with the beginning of unplanned pregnancy, were in low level except psychological and patriarchic beliefs parts. Onset of violence because of unplanned pregnancy can harm mother and child health significantly and needs urgent interventions.
Zero-Profile Versus Cage and Plate in Anterior Cervical Discectomy and Fusion for the Treatment of single- level Traumatic Cervical Disc Herniation: A Minimum of Three-Year Follow-Up Study
Authors: Zhao Wenjie , Zhang Yu , Hu Man , Liu Xin , Yang Jiandong , Tao Yuping , Wang Yongxiang , Feng Xinmin , Zhang Liang
Published: November 2022

Background
Compared with cage and plate, Zero-Profile device in single and multi-level anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc diseases shows similar efficacy in improving functional and radiologic outcomes, and reducing incidence of complication rate, especially dysphasia. Whether Zero-Profile device is appropriate for ACDF in the treatment of single-level symptomatic traumatic cervical disc herniation is still unknow. We compare the mid-term efficacy and safety in ACDF using Zero-Profile device with cage and plate for the treatment of single-level traumatic cervical disc herniation.
Methods
From Aug 2014 to Aug 2018, 53 patients with symptomatic traumatic cervical disc herniation underwent ACDF with Zero-Profile device (Group ZP) or cage and plate (Group CP) were included. The clinical outcomes (Japanese Orthopedic Association score (JOA), Neck Disability Index (NDI) score, Visual Analogue Scale (VAS) score, radiological outcome and complications were reviewed and compared.
Results
All procedures were successfully performed in all patients. The JOA score, NDI score, VAS score and cervical lordosis were significantly improved postoperatively in both groups (P < 0.05), but there were no significant differences between the two groups at each follow-up time (P > 0.05). There were no significant differences in fusion rate and cage subsidence rate between the two groups (P > 0.05). However, the dysphagia rate at postoperative immediately, 1 week and 1 month in Group ZP (14.8%, 11.10% and 3.7%) were lower than those of Group CP (21.7%, 17.4% and 13.0%) (P > 0.05). All patients achieved solid fusion and no patient had dysphagia at final follow-up.
Conclusions
ACDF with Zero-Profile device can not only obtain similar surgical effects compared with cage and plate in the treatment of single-level traumatic cervical disc herniation, but may reduce the incidence of dysphagia rate at early post operative period. Therefore, ACDF with Zero-Profile can be used as an effective and reliable treatment for single-level traumatic cervical disc herniation.
The Effect of a Differentiated Problem-Based Science Program on Gifted Students' Cooperative Working Skills and Problem-solving Skills
Authors: CEYLAN Özge , UMDU TOPSAKAL Ünsal
Published: November 2022

Introduction: Effectively solving complex and challenging problems in all areas of modern life and cooperating in this process have come to the fore in recent years. This study aimed to develop gifted middle-school students’ problem-solving and cooperative working skills through a differentiated science program based on problem-solving.Method: The study was designed as an action research study. The participants were 12 seventh-grade (11-12 years old) gifted students and a researcher who was also a teacher. The researchers prepared the problem-based differentiated science teaching module and applied it to the participants for 14 weeks. Qualitative and quantitative data collection tools were used in the study. The Problem-solving Skills Questionnaire and student diaries were used to reveal the development of problem-solving. The Cooperative Process Scale and student diaries were used to reveal development of cooperative working skills. Descriptive statistics and Wilcoxon Signed Rank Test were used to analyze quantitative data, and thematic analysis was used to analyze qualitative data.Findings: The qualitative and quantitative findings of the study showed that the problem-based differentiated science teaching module improved the gifted students’ cooperative working and problem-solving skills.Discussion: This study suggests that the differentiated science program was effective in the development of the gifted students’ cooperative working and problem-solving skills. Studies in the literature support this result. In future studies, it is recommended that differentiated programs be prepared with different subject contents and that their effectiveness be investigated.
Mental health help-seeking intentions: The role of personality traits in a sample of college students
Authors: Shabrina Arina , Siswadi Ahmad Gimmy Prathama , Ninin Retno Hanggarani
Published: November 2022

Many college students with mental health problems do not seek help. One of the predisposing factors that influences mental health help-seeking is personality traits. This study aims to explore the role of such traits in the mental health help-seeking intention of college students. It is a cross-sectional study using the correlational method. An online survey employing convenience sampling technique was completed by 480 participants. The survey covered demo­graphic data, the Big Five Inventory, and a mental health help-seeking intention questionnaire. The data were analyzed using descriptive statistics, Pearson’s correlation coefficient, and multivariate regression analysis. Conscientiousness (b = .170, p-value = .000) was significantly associated with a higher intention to seek mental health help. Higher neuroticism also predicted higher mental health help-seeking intentions (b = .165, p-value = .001). On the other hand, openness, extra­version, and agreeableness did not predict such intentions. The results suggest that personal disposition could affect help-seeking intentions and that certain personality traits had more impact on these. It is hoped that the results will contribute to providing better mental health support for students and promote help-seeking.