bluuebunny/crossref_metadata_2025 huggingface dataset:
APLIKASI BOKASHI KULIT NENAS DAN PUPUK NPK ORGANIK UNTUK PENINGKATAN.PERTUMBUHAN.DAN HASIL TANAMAN.TERUNG.UNGU (Solanum melongena L.)
Authors: Ahmad Ruliansyah  , Ernita  , Sri Mulyani
Published: January 2023

The aim of the work was to find out the interaction between pineapple peel bokashi and organic NPK fertilizer and the main effect in increasing the growth and yield of purple eggplant (Solanum melongena L.). The study was conducted at the experimental farm of the Faculty of Agriculture of the Riau Islamic University from February to May 2020. This experimental design was 4 x 4 factorial using a completely randomized design with 3 replications. The first factor was the dose of pineapple peel bokashi consists of 4 levels: 0, 0.75, 1.5, 2.25 kg per plot. The second factor was the dose of NPK organic Fertilizer, consisting of 4 level: 0, 7.5, 15.0, 22, 5 gram per plant. The parameters observed were plant height, flowering age, harvest age, number of fruit crops, weight of fruit per plant, weight of fruit per fruit, number of residual fruits. The data were analyzed statistically and continued with the real difference test (BNJ) at the 5% level. The results showed that the interaction of pineapple peel bokashi and organic NPK had a significant effect to all observation parameters and the best treatment was a combination of pineapple skin bokashi 2.25 kg/plot and NPK organic 22.5 g/plant. The main effect of pineapple peel bokashi dose was significant on all observed parameters with the best treatment was 2.25 kg / plot. The main effect of organic NPK was significant for all parameters. The best treatment was found on organic NPK dose of 22.5 g/plant.
PENGARUH PEMBERIAN MADU SIALANG DENGAN DOSIS BERBEDA TERHADAP JANTANISASI IKAN CUPANG (Betta sp)
Authors: Rendy Alsiawan  , Muhammad Hasby
Published: January 2023

The aim of this study is to determine the effect of giving sialang honey with different doses on the monetization of Betta fish (Betta sp). and to know the best dose for male betta fish. The method used in this study is an experimental method using a completely randomized design (CRD) with 5 treatments and 3 replications, namely: P0 (control), P1 (5 ml/L), P2 (6 ml/L), P3 (7 ml /L) and P4 (8 ml/L). The test fish used was obtained from a betta fish seller in Jalan Pasir Putih. The container used was a jar with a capacity of 10 liters as many as 15 pieces. The best results were obtained at P4 (8 ml/L) with the percentage of male sex directing success of 81.79%. The highest larval survival was found in treatment P4 (8 ml/L) at 78.89%. The results of the measurement of water quality parameters during the study temperature ranged from 28-32oC, pH 6.5-7, ammonia 0.08-0.58 ppm, DO 4.8-5.4 ppm. The brightness was 30-60 cm and the depth was between 0.9-1.1 cm.
Pathophysiological aspects of the development of cerebral atherosclerosis
Authors: А.Т. Гусейнова, , Н.В. Соловьева, , Е.В. Тихонова, , Е.А. Лебединцева,
Published: January 2023

Сосудистые заболевания головного мозга на сегодняшний день являются важнейшей медико-социальной проблемой. Одним из ведущих факторов развития данной патологии является атеросклеротическое поражение церебральных сосудов. Обзор посвящен патогенетической значимости биохимических маркёров при церебральном атеросклерозе. Рассмотрены современные данные о механизмах, лежащих в основе атеросклеротического поражения сосудов. Показано участие эндотелиальной дисфункции, окислительного стресса, воспаления и нарушений липидного обмена в патогенезе атеросклероза. Отмечена роль таких биохимических маркёров, как эндотелин-1, оксид азота, адипонектин, интерлейкин-6, интерлейкин-1β, С-реактивный белок, фактор некроза опухоли-альфа в развитии атеросклероза и показана их взаимосвязь с клиническими проявлениями церебрального атеросклероза.

Cerebrovascular disease is the most important current medical and social challenge. Cerebral atherosclerosis is one of the leading factors in the development of this pathology. This review focuses on the pathogenetic significance of biochemical markers for cerebral atherosclerosis. The modern view of the mechanisms underlying atherosclerotic lesions is addressed in detail. The review shows the involvement of endothelial dysfunction, oxidative stress, and lipid metabolic disorders in the pathogenesis of atherosclerosis. The authors highlighted the role of biochemical markers, such as endothelin-1, nitric oxide, adiponectin, interleukin-6, interleukin-1ß, C-reactive protein, and tumor necrosis factor-alpha, in the development of atherosclerosis and underlined their relationship with clinical manifestations of cerebral atherosclerosis.
Dynamics of ectopic stress granules in cells FRSN and EA.hy926
Authors: А.Ю. Пасько, , А.А. Микрюкова, , Д.М. Зайченко, , А.А. Московцев, , А.А. Кубатиев,
Published: January 2023

Стрессорные гранулы (СГ) - цитоплазматические рибонуклеопротеиновые ассоциаты, формирующиеся при остановке кеп-зависимой трансляции в эукариотических клетках под действием стрессорных факторов, таких, как повышенная температура, гипоксия, ультрафиолет и др. СГ могут также спонтанно собираться при повышении экспрессии их белковых компонентов. В данной работе были экспрессированы в клетках FRSN и EA.hy926 компоненты СГ - белки TIA1 и G3BP1, в виде слитых с флуоресцентным EGFP белком гранул, что позволило визуализировать динамику СГ. Нами обнаружена спонтанная сборка и стабильная персистенция СГ после трансфекции. Однако частота диссоциации СГ возрастала с увеличением времени от трансфекции. При стрессе ЭПР, индуцированном дитиотреитолом, число клеток с СГ возрастало, однако, как правило, это была поздняя нуклеация СГ, что мы предполагаем связанным с присоединившимися вторичными стрессовыми факторами на фоне стресса ЭПР. С учетом важной роли СГ в выживании клеток мониторинг СГ дает дополнительную информацию о механизмах клеточного стрессового ответа в культурах клеток FRSN и EA.hy926.

Stress granules (SGs) are cytoplasmic ribonucleoprotein associates that are formed when the cap-dependent translation is attenuated in eukaryotic cells during cellular stress caused by elevated temperature, hypoxia, ultraviolet light, etc. SGs can also spontaneously assemble upon overexpression of their protein components. In this work, the SG components, TIA1 and G3BP1 proteins, were expressed in FRSN and EA.hy926 cells as a fusion protein with fluorescent EGFP, which enabled visualization of artificial SGs. We found spontaneous assembly and stable persistence of SG following the transfection. However, the frequency of SG dissociation increased with increasing time after the transfection. Under the ER stress induced by dithiothreitol, the number of cells with SGs increased. However, that was a generally late nucleation of SGs. This we assumed was related to secondary stress factors that had joined during oER stress. Given the important role of SGs in cell survival, monitoring of SGs provides additional information on the mechanisms of cellular stress response in FRSN and EA.hy926 cells.
TRANSFER FUNCTION ALONG PRESSURE VIBRATION TWOLAYER LIQUID IN RIDGID RACTIANGULAR TANK
Authors: А.А. Пожалостин, , Д.А. Гончаров,
Published: January 2023

В данной статье решается краевая задача об определении передаточной функции по давлению колеблющейся двухслойной жидкости в жестком прямоугольном баке.

In this article decision bordery task adout determination transfer function alon pressure vibration twolayer liquid in ridgid ractiangular tank.
FLUCTUATIONS AND NOISES IN PHYSICOCHEMICAL SYSTEMS: CLASSIFICATION OF RESEARCH METHODS
Authors: М.А. Абатуров,
Published: January 2023

Была проведена систематизация различных подходов в исследованиях флуктуационно-шумовых явлений физико-химических систем. Выделены три основные группы в зависимости от характера анализируемых сигналов: импульсные, непрерывные и стационарные шумы. Сделан вывод о перспективности исследований стационарных шумов, позволяющих проводить измерения на прецизионном уровне.

The systematization of various approaches in the studies of fluctuation-noise phenomena of physicochemical systems was carried out. Three main groups are distinguished depending on the nature of the analyzed signals: pulsed, continuous and stationary noises. The conclusion is made about the prospects of studies of stationary noises that allow measurements to be carried out at a high precision level.
FORMATION OF A UNIVERSAL BIOTECHNICAL SUPPORT SYSTEM FOR SIBERIAN ROE DEER (CAPREOLUS PYGARGUS) IN CONDITIONS OF SNOWFALL
Authors: В.Б. Ермолик,
Published: January 2023

Период высокоснежья на заповедных территориях Западной Сибири настоятельно требует новых биотехнических концепций в кормовой поддержке и сохранении популяций сибирской косули. В данной статье, на основе многолетнего мониторинга, приводится вывод, что стихийные, системно не оформленные приемы биотехнии не приводят к желаемому эффекту и, в нередких случаях, в своей кормовой несостоятельности могут привести к массовой гибели косули. Научное разрешение этой застарелой биологической проблемы было осуществлено на территории государственного природного заказника федерального значения «Кирзинский», расположенного в Новосибирской области. Здесь были проведены научные исследования, цель которых была направлена не только на кормовое упреждение в сохранении репродуктивного ядра популяции косули в период зимних аномалий, но и применение в зимнем питании косули высокоэнергетических культур и растений, в реестр которых вошли люцерна, овес, горох, подсолнечник и пшеница. На основе данных опытной базы была разработана и внедрена универсальная система биотехнической поддержки сибирской косули в условиях многоснежья. Данные новации напрямую отразились на динамике численности поголовья сибирской косули. В 2007 году численность косули в заказнике достигла критических величин – 156 голов. Однако за 15 лет функционирования новой биотехнической универсальной системы население этого биологического вида возросло в 13 раз и достигло показателя – 2144 особи.

The period of high snow in the protected areas of Western Siberia urgently requires new biotechnical concepts in feed support and conservation of Siberian roe deer populations. In this article, on the basis of long-term monitoring, it is concluded that spontaneous, systemically unformed techniques of biotechnologies do not lead to the desired effect and, in frequent cases, in their feed failure can lead to mass death of roe deer. Scientific resolution of this long-standing biological problem was carried out on the territory of the state nature reserve of federal significance «Kirzinsky», located in the Novosibirsk region. Scientific research was carried out here, the purpose of which was aimed not only at forage prevention in preserving the reproductive core of the roe deer population during winter anomalies, but also the use of high-energy crops and plants in the winter feeding of roe deer, the register of which included alfalfa, oats, peas, sunflower and wheat. Based on the data of the experimental base, a universal system of biotechnical support for Siberian roe deer in conditions of snowfall was developed and implemented. These innovations directly affected the dynamics of the number of Siberian roe deer. In 2007, the number of roe deer in the reserve reached critical values – 156 heads. However, over the 15 years of operation of the new biotechnical universal system, the population of this biological species has increased 13 times and reached an indicator of 2144 individuals.
MEASUREMENT OF VARIATIONS IN THE ATMOSPHERIC ELECTRIC FIELD IN CHITA
Authors: А.К. Козлов, , В.А. Казанцев, , В.Б. Венславский,
Published: January 2023

Для регистрации вертикальной составляющей напряжённости атмосферного электрического поля в г. Чита усовершенствован прототип электростатического флюксметра. Записи напряжённости атмосферного электрического поля позволяют исследовать процессы в дождевых и грозовых облаках. Флюксметр был использован для регистрации возможного проявления предвестника землетрясения с эпицентром под озером Байкал магнитудой 7 баллов (в городе Чита 08.06.22 около 21:30, 2 балла).

To register the vertical concentration of the atmospheric field strength in the city of Chita, a prototype of an electrostatic fluxmeter has been improved. Atmospheric forcing records arise from the occurrence of events in rain and thunderclouds. The fluxmeter was used to register a possible manifestation of an earthquake precursor with an epicenter under Lake Baikal with a magnitude of 7 points (in the city of Chita on June 08, 22 at about 21:30, 2 points).
DEVELOPMENT OF AN AUTOMATED SYSTEM FOR REMOTE MONITORING AND DIAGNOSTICS OF MICROCLIMATE IN POLYMER AGRICULTURAL SLEEVES FOR GRAIN STORAGE 1
Authors: Т.Ю. Никонова, , О.М. Жаркевич, , М.М. Баймульдин, , Е.С. Дандыбаев, , А.А. Калинин,
Published: January 2023

Авторами в статье проведен обзор и анализ существующих методов хранения зерновых культур; изучены требования к режимам хранения зерновых культур; поставлена задача разработки автоматизированной системы удаленного мониторинга и диагностики микроклимата в полимерных сельскохозяйственных рукавах для хранения зерна, описаны требования, которым должна соответствовать данная система. Также в статье приведено описание разработанного авторами мобильного приложения предназначенного для дистанционного контроля за состоянием сухого зерна (крупы или другого злака) под пленочным покрытием или в пленочном рукаве.

The authors of the article conducted a review and analysis of existing methods of grain storage; studied the requirements for grain storage regimes; set the task of developing an automated system for remote monitoring and diagnostics of microclimate in polymer agricultural sleeves for grain storage, described the requirements that this system must meet. The article also describes a mobile application developed by the authors designed for remote monitoring of the condition of dry grain (cereals or other cereals) under a film coating or in a film sleeve.
INVESTIGATION OF A LINK OF VARIABLE LENGTH WITH CONTROLLED RIGIDITY USING A MAGNETIC-RHEOLOGICAL MEDIUM BY THE METHOD OF MATHEMATICAL MODELING
Authors: А.О. Блинов,
Published: January 2023

В статье предлагается математическая модель звена экзоскелета переменной длины с управляемой жесткостью с использованием магнитно-реологической среды. Проводится исследование его механических свойств методом математического моделирования.

The article proposes a mathematical model of a variable length exoskeleton link with controlled stiffness using a magnetic rheological medium. A study of its mechanical properties is carried out by the method of mathematical modeling.
Тапиаит из Чаувайского рудного поля – вторая находка в мире
Authors: В.Ю. Карпенко, , Л.А. Паутов, , А.А. Агаханов, , М.А. Мираков, , О.И. Сийдра,
Published: January 2023

На Au-месторождении Обдиля в пределах Чаувайского рудного поля (Кыргызстан) вскрыта мышьяковая минерализация, в составе которой встречен тапиаит Ca5Al2(AsO4)4(OH)4·12H2O, до этого известный лишь на месторождении Хоте (Jote Mine, Чили). Минерализация приурочена к карбонатным толщам толубайской свиты (С1–С2) и представлена аурипигментом, реальгаром, владимиритом, мансфельдитом, талмесситом, высококальциевыми представителями серии фармакоалюмита–фармакосидерита, рентгеноаморфными K-Ca-Fe-Al-арсенатами. Тапиаит формирует агрегаты белых с шелковистым блеском радиально-лучистых образований (100–250 мкм), сложенных уплощенно-призматическими, брусковидными кристаллами с гранями {10͞1}, {101} и {232} (?). Длина отдельных кристаллов 10–50 мкм, обычны двойники. Минерал оптически двуосный положительный. Кристаллы тапиаита имеют прямое угасание относительно удлинения, np = 1.578(2), ng = 1.609(2), плеохроизм отсутствует. Химический состав центральной (центр) и краевой (кр) частей радиально-лучистых агрегатов несколько отличается по сумме (микрозонд, вес.%; центр/кр): As2O5 45.42/43.39, Sb2O5 0.06/0.32, SiO2 0.02/0.09, Al2O3 9.82/9.64, Fe2O3 0.19/0.02, CaO 27.17/26.44, SO3 0.13/0.00, сумма (без H2O) 82.83/79/90; H2O по разности 17.17/20.10. Пересчет на 11 атомов (Ca+Al+Fe+As+S) приводит к формуле Ca4.95Al1.97Fe0.02[As4.03S0.02O16](OH)4.17·7.65H2O для центральной части сферолитоподобных агрегатов и Ca4.98Al2.00[As3.99Sb0.02Si0.02O16](OH)4.09·9.74H2O для краевой. Обсуждаются возможные причины более высоких сумм анализов по сравнению с тапиаитом с места первого описания. Приведена рентгеновская порошкограмма тапиаита, для монокристалла (пространственная группа P21/n), получены параметры элементарной ячейки a = 16.03(1), b = 5.81(2), c = 16.32(2) Å, β = 116.7(2)°, Z = 2. Для тапиаита из Обдиля и Хоте приведены рамановские спектры. Образование тапиаита может быть связано с приповерхностной разгрузкой вод, обогащенных As, а также с процессами изменения первичных As-минералов.
A “short blanket” dilemma for a state-of-the-art neural network potential for water: Reproducing experimental properties or the physics of the underlying many-body interactions?
Authors: Zhai Yaoguang , Caruso Alessandro , Bore Sigbjørn L. , Luo Zhishang , Paesani Francesco
Published: January 2023

Deep neural network (DNN) potentials have recently gained popularity in computer simulations of a wide range of molecular systems, from liquids to materials. In this study, we explore the possibility of combining the computational efficiency of the DeePMD framework and the demonstrated accuracy of the MB-pol data-driven many-body potential to train a DNN potential for large-scale simulations of water across its phase diagram. We find that the DNN potential is able to reliably reproduce the MB-pol results for liquid water but provides a less accurate description of the vapor-liquid equilibrium properties. This shortcoming is traced back to the inability of the DNN potential to correctly represent many-body interactions. An attempt to explicitly include information about many-body effects results in a new DNN potential that exhibits opposite performance, being able to correctly reproduce the MB-pol vapor-liquid equilibrium properties but losing accuracy in the description of the liquid properties. These results suggest that DeePMD-based DNN potentials are not able to correctly "learn" and, consequently, represent many-body interactions, which implies that DNN potentials may have limited ability to predict properties for state points that are not explicitly included in the training process. The computational efficiency of the DeePMD framework can still be exploited to train DNN potentials on data-driven many-body potentials, which can thus enable large-scale, "chemically accurate" simulations of various molecular systems, with the caveat that the target state points must have been adequately sampled by the reference data-driven many-body potential in order to guarantee a faithful representation of the associated properties.
Room Temperature Cu-Catalyzed Amination of Aryl Bromides Enabled by DFT-Guided Ligand Design
Authors: Kim Seoung-Tae , Strauss Michael J. , Cabré Albert , Buchwald Stephen L.
Published: January 2023

Ullman-type C–N coupling reactions represent an important alternative to well-established Pd-catalyzed approaches due to the differing reactivity and the lower cost of Cu. While the design of anionic Cu ligands, particularly those by Ma, has enabled the coupling of various classes of aryl halides and alkyl amines, most methods require conditions that can limit their utility on complex substrates. Herein, we disclose the development of anionic N1,N2-diarylbenzene-1,2-diamine ligands that promote the Cu-catalyzed amination of aryl bromides under mild conditions. Guided by DFT-calculations, these ligands were designed to (1) increase the electron density on Cu, thereby facilitating the rate of oxidative addition of aryl bromides, and (2) stabilize the active anionic CuI complex via a π-interaction. Under optimized conditions, structurally diverse aryl and heteroaryl bromides and a broad range of alkyl amine nucleophiles, including pharmaceuticals bearing multiple functional groups, were efficiently coupled at room temperature. Combined computational and experimental studies support a mechanism of C–N bond formation that follows a catalytic cycle akin to the well-explored Pd-catalyzed variants. Modification of the ligand structure to include a naphthyl residue resulted in a lower energy barrier to oxidative addition, providing a 30-fold rate increase relative to what is seen with other ligands. Collectively, these results establish a new class of anionic ligands for Cu-catalyzed C–N couplings which we anticipate may be extended to other Cu-catalyzed C–heteroatom and C–C bond-forming reactions.
A Graph Convolutional Network for Elution Order Prediction in Chromatographic Enantioseparation
Authors: Galvin Casey , Nagai Kanji , Kaneko Yu , Yuki Shinya
Published: January 2023

Chromatography using chiral columns is the most effective method for determining the optical purity of enantiomer pairs, although identifying the absolute configuration of each peak is difficult and remains a challenging issue. We demonstrate a solution to this challenge based on machine learning in this study. We used a dataset that consists of retention times of absolute configurations of enantiomer pairs on CROWNPAK CR-I(+) and CR(+) columns to train a variety of neural network architectures. Our findings show that graph-based neural networks achieve superior prediction accuracy despite the relatively small dataset. Specifically, the model shows enantiomer elution order prediction accuracy of 88.9% for CR-I(+) and 88.4 % for CR(+) columns. We then predicted elution order for molecule types not contained in the original dataset, in order to test this model’s ability to generalize to new molecules. The overall accuracy across both column types was 81.0 %, indicating that our prediction model can be used for virtual experiments on enantioseparation before conducting actual experiments and analysis of column fractions.
Sarglamides A–E, Indolidinoid-Monoterpenoid Hybrids with Anti-Neuroinflammatory Activity from a Sarcandra Species
Authors: Zhou Bin , Gong Qi , Fu Yan , Zhou Jun-Su , Zhang Hai-Yan , Yue Jian-Min
Published: January 2023

Sarglamides A–E (1−5), representing the first example of heterodimers of a trans-N-cinnamoylindolidinoid and an α-phelladrene derivatives, were isolated from Sarcandra glabra subsp. brachystachys. Particularly, compounds 4 and 5 possess unprecedented cage-like 6/6/5/6/5- and 6/6/6/6/5-fused pentacyclic scaffolds, respectively. Their structures were established by spectroscopic analysis, X-ray crystallography, quantum chemical calculations, and chemical conversions. Plausible biosynthetic pathways of 1−5, involving the co-isolated enantiomers 6a and 6b were proposed. Compounds 3–7 showed inhibitory activity against lipopolysaccharide (LPS) induced inflammation in BV-2 microglial cells.
Masked alkynes for synthesis of threaded carbon chains
Authors: Patrick Connor , Gao Yueze , Gupta Prakhar , Thompson Amber , Parker Anthony , Anderson Harry
Published: January 2023

Polyynes are chains of sp1 carbon atoms with alternating single and triple bonds. As they become longer, they evolve towards carbyne, the 1D allotrope of carbon, and they become increasingly unstable. It has been anticipated that long polyynes could be stabilized by supramolecular encapsulation, by threading them through macrocycles to form polyrotaxanes, but, until now, polyyne polyrotaxanes with many threaded macrocycles have been synthetically inaccessible. Here we show that masked alkynes, in which the CC triple bond is temporarily coordinated to cobalt, can be used to synthesize polyrotaxanes, up to the C68 [5]rotaxane with 34 contiguous triple bonds and four threaded macrocycles. This is the length regime at which the electronic properties of polyynes converge to those of carbyne. Cyclocarbons constitute a related family of molecular carbon allotropes, and cobalt-masked alkynes also provide a route to [3] and [5]catenanes built around cyclo[40]carbon and cyclo[80]carbon, respectively.
Variable Amine Spacing Determines Depolymerization Rate in Polydiketoenamines
Authors: Epstein Alex , Demarteau Jeremy , Helms Brett , Persson Kristin
Published: January 2023

The design of circular polymers has emerged as a necessity due to the lack of efficient recycling methods for many commodity plastics, particularly those used in durable products. Among the promising circular polymers, polydiketoenamines (PDKs) stand out for their ability to undergo highly selective depolymerization in strong acid, allowing monomers to be recovered from additives and fillers. Varying the triketone monomer in PDK variants is known to strongly affect the depolymerization rate; however, it remains unclear how the chemistry of the crosslinker, far from the reaction center, affects the depolymerization rate. Here, we elucidate design rules for PDK acidolysis from a convergence of simulations and experiments. We demonstrate that a multi-path transition state theory approach to calculating reaction kinetics is essential to accurate modeling of small molecule hydrolysis kinetics and that the computational results match closely to experimental observations of both small molecule hydrolysis kinetics and PDK depolymerization. Notably, we found that a proximal amine in the crosslinker dramatically accelerates PDK depolymerization when compared to crosslinkers obviating this functionality. Moreover, the spacing between this amine and the diketoenamine bond offers a previously unexplored opportunity to tune PDK depolymerization rates. In this way, the molecular basis for PDK circularity is revealed and further suggests new targets for the amine monomer design to diversify PDK properties, while ensuring circularity in chemical recycling.
Motherhood and infant feeding: Historical aspects and current practice: A review
Authors: Zakharova Irina N. , Sugian Narine G. , Kosareva Angelina A. , German Natalia V. , Orobinskaia Iana V. , Pupykina Viktoriya V.
Published: January 2023

In recent years there has been a deterioration in demographic indicators: a decrease in the birth rate, an increase in adult mortality, etc., due to numerous causes. In this context, the article addresses demographic issues related to subcultures and ideologies, such as childfree. The main characteristics of people classified as rejecters, aficionados, refusers, and postponers are discussed. We present the first results of a study conducted at the Khimki regional hospital. The study included 25 pregnant women. The survey results showed that most were planning a pregnancy before 30. A survey of expectant mothers indicated a positive attitude towards breastfeeding. The article discusses the issues of breastfeeding as an essential stage in forming a child's immunity and the factors of breastfeeding success. Women's nutrition during pregnancy and breastfeeding should be diverse and rich in vitamins and micronutrients. Special maternal drinks, such as Amalthea, based on New Zealand goat milk, can benefit breastfeeding. In the absence of breast milk, the selection of formula for the baby is one of the most challenging issues. It is important that the infant formula meet the child's nutritional needs to the maximum extent possible, including the functional milk components. For instance, the Nanny formula is based on New Zealand goat milk, using a single heat treatment process without separating milk into fractions, which preserves the native functional components of goat milk (oligosaccharides, nucleotides, milk fat).
Algorithm of local conservative treatment of children with burns
Authors: Budkevich Liudmila I. , Soshkina Vera V.
Published: January 2023

Background. This article presents the results of using atraumatic wound dressings Branolind N and sorbing bandage Zetuvit. In research there were 10 children with superficial scalds (III degree) and parcial deep (IIIII degree) burns. Children were treated at the Burn Center of Speransky Pediatric City Hospital №9 in Moscow in June November 2021. The analysis of the conducted research testifies to the effectiveness and safety of the medical products listed above. The absence of local complications during treatment was revealed. The possibility of their simultaneous use in patients with exudating wounds has been established. Branolind N and Zetuvit bandage can be recommended for use both in a on- and outpatient cases in children with local burns. The results of treatment of children with burn injury depend on adequate diagnosis of the severity of the burn trauma, reliable determination of the depth of scald and local treatment of burn wounds. Tactics of local treatment depends on the phase of wound process, the age of the child and the presence of concomitant diseases.
Aim. To assess the effectiveness and safety of using wound dressings ointment dressing Branolind N with Peruvian balsam and Zetuvit sorbent dressing in treatment children with burns.
Materials and methods. Analysis of the using of Branolind N ointment dressing with Peruvian balsam and Zetuvit sorbent dressing in 10 children with burn injury was carried out. The study was completed in June November 2021. Inclusion and exclusion criteria were determined by the physicians participating in the study. The studies were carried out in accordance with Helsinki Declaration. The age of the patients ranged from 3 years 2 months up to 17 years 1 month. The depth of burn wounds in the studied patients was assessed according to the classification of the damage degree of European Burn Association: patients with superficial scalds (III degree) and partial deep burns (IIIII degree).
Results. The absence of local skin complications during the application of the Branolind N ointment dressing with Peruvian balsam and Zetuvit sorbent dressing was revealed. The possibility of using. These wound dressings in patients with exuding wounds was established.
Conclusion. The analysis of the conducted study testifies to the effectiveness and safety of the above medical products. Ointment bandage Branolind N with Peruvian balsam and sorbent bandage Zetuvit can be recommended for use both in out- and inpatients practice of treatment children with local skin burns.
Resolution of the Expert Council on the use of the anti-inflammatory drug ammonium glycyrrhizinate in the treatment of acute respiratory infections and allergic diseases of the respiratory tract
Authors: Geppe Natalia A. , Malakhov Aleksandr B. , Boitsova Evgeniia V. , Gaimolenko Inessa N. , Ermakova Irina N. , Zaitsev Andrei A. , Ivakhnenko Evgenii F. , Il'enkova Natalia A. , Kamaev Andrei V. , Kliukhina Iuliia B. , Kondiurina Elena G. , Konova Olga M. , Kulagina Vera V. , Lev Natalia S. , Liutina Elena I. , Megirian Manuel M. , Mel'nikova Irina M. , Meshcheriakov Vitalii V. , Mizernitskii Iurii  L. , Mironova Alena K. , Mikhalev Evgenii V. , Mozzhukhina Lidiia I. , Odinaeva Nuriniso D. , Pavlinova Elena B. , Pobedinskaia Nadezhda S. , Skachkova Margarita A. , Soroka Natalia D. , Trishina Svetlana V. , Tsar'kova Sofia A. , Shuliak Irina P.
Published: January 2023

In June 2022, within the XI International Educational Consensus on Respiratory Medicine in Pediatrics, an expert council on the anti-inflammatory agent ammonium glycyrrhizinate in treating acute respiratory infections and allergic diseases of the respiratory tract was held in Vladimir. The resolution of the Expert Council is presented. Based on these studies, experts recommend the use of ammonium glycyrrhizinate in patients with acute respiratory tract infection (including COVID-19); in the rehabilitation period of patients who recovered from the new coronavirus infection with lung involvement; patients with recurrent obstructive bronchitis, including those at high risk of bronchial asthma; patients with allergic rhinitis; patients with mild to moderate asthma.
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Authors: Injeti Neelam
Published: January 2023

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MODERN MARKETING TRENDS AFFECTING BUSINESS
Authors: Татьяна Анатольевна Бадикова, , Анна Борисовна Соловьева,
Published: January 2023

Для построения успешного бизнеса в современных условиях необходимо понимать условия новой реальности, ключевые проблемы глобального уровня и основные тренды в маркетинге. Цель исследования - рассмотреть глобальные процессы развития современного общества и преобладающие тенденции маркетинга, понимание и следование которым будет способствовать построению конкурентоспособного бизнеса. В статье определены преобладающие векторы развития общества, формирующие новые условия функционирования бизнеса, раскрыты современные тренды маркетинга, учет которых позволит боле гибко реагировать на вызовы внешней среды, повышая конкурентоспособность компаний в современных условиях.

The opening and development of their own small and medium-sized businesses are becoming more and more in demand among young people graduating from higher education institutions in our time. In order to build a business and achieve success, today it is necessary to understand the conditions of the new reality, its mechanisms and conditions of existence. Business, existing now, must understand the key problems of the global level (megatrends) and the main trends in marketing. It is thanks to this understanding that preparing for the future and living in this very future will be the least painful for business. After all, he, developing, is forced to do this under the influence of instability and uncertainty.
TRENDS AND CHALLENGES OF SMALL BUSINESS DEVELOPMENT IN THE SPHERE OF TRADE OF THE RUSSIAN FEDERATION
Authors: Наталья Евгеньевна Царёва, , Али оглы Гунбатов, Самир
Published: January 2023

Цель статьи - выявить тенденции и проблемы развития малого бизнеса в сфере торговли Российской Федерации. Торговля является наиболее активно развивающейся отраслью экономики нашей страны и остается наиболее привлекательной сферой для малого бизнеса. В статье рассматриваются состояние и проблемы развития малых торговых предприятий в связи с введением санкций, меры государственной поддержки малого бизнеса сферы торговли. Элемент научной новизны заключается в раскрытии тенденций развития малых торговых предприятий и обобщении мер их государственной поддержки на современном этапе.

The purpose of the article is to identify trends and problems in the development of small businesses in the field of trade of the Russian Federation. Trade is the most actively developing sector of our country's economy and remains the most attractive area for small businesses. The article discusses the state and problems of the development of small trade enterprises in connection with the introduction of sanctions, measures of state support for small businesses in the field of trade. An element of scientific novelty lies in the disclosure of trends in the development of small trade enterprises and the generalization of measures of their state support at the current stage.
WEB-MAPPING THE ACCESSIBLE ENVIRONMENT THE CITY OF TVER
Authors: Дмитрий Адольфович Мидоренко,
Published: January 2023

В статье предложена методика формирования базы географических данных объектов доступной (безбарьерной) среды с использованием мобильного ГИС-приложения, последующим web-картографированием и представлением результатов в виде Интернет-карты доступности.

The article proposes a method for forming a geographic database of objects in an accessible (barrier-free) environment using a mobile GIS application, followed by web mapping and presenting the results in the form of an Internet map of accessibility.
THE ROLE OF MIGRATION MOVEMENT IN FORMING THE POPULATION OF THE TVER REGION
Authors: Ольга Александровна Бойкова, , Анна Сергеевна Щукина,
Published: January 2023

Миграционное движение оказывает влияние на динамику численности, структуру населения и как следствие на динамику социально-экономических процессов как стране в целом, так и в отдельных регионах. В данной статье на основе материалов Всероссийской переписи населения 2010 г., данных текущего учета и полевого исследования дана оценка влияния миграционного движения на динамику численности и генетическую структуру населения Тверской области.

The migration movement has an impact not only on the dynamics of the size and structure of the population, but also on the dynamics of the socio-economic development of both the country as a whole and individual regions. On the basis of the data of the current record, materials of the All-Russian population census of 2010, field research, the influence of migration movement on the dynamics of the number and genetic structure of the population of the Tver region and the Maksatikha district is analyzed.
GLOBAL CITIES - INTERNATIONAL TRAVEL CENTERS
Authors: Никита Дмитриевич Соколов, , Светлана Ивановна Яковлева,
Published: January 2023

Цель исследования - доказать, что современные глобальные города являются крупными международными туристскими центрами. Научная новизна - обращение к категории «глобальные (мировые) города» в географии туризма с использованием актуального экспертного ранжирования таких городов (из Доклада о глобальных городах 2022 г.) и авторского анализа ключевых показателей городской статистики туризма и транспорта. Основной метод - статистическое и графическое сравнение глобальных городов для получения количественного представления о роли этих городов в мировом туристском пространстве.

The purpose of the study is to prove that modern global cities are major international tourist centers. Scientific novelty - addressing the category of "global (world) cities" in the geography of tourism using the current expert ranking of such cities (from the Global Cities Report 2022) and the author's analysis of key indicators of urban tourism and transport statistics. The main method is a statistical and graphical comparison of global cities in order to obtain a quantitative idea of the role of these cities in the global tourism space.
HISTORICAL AND GEOGRAPHICAL BACKGROUND AND FACTORS FOR THE FORMATION OF THE SETTLEMENT SYSTEM IN THE SVERDLOVSK REGION (BY THE EXAMPLE OF URBAN-TYPE SETTLEMENTS)
Authors: Михаил Александрович Григорович,
Published: January 2023

Статья посвящена становлению системы расселения микроуровня в рамках региона - сети поселков городского типа в Свердловской области. Обзор ведется с момента освоения территории региона в XVI-XVII веках до современного периода. Выделяются факторы трансформации сети поселков городского типа.

The article is devoted to the formation of a micro-level settlement system within the region - a network of urban-type settlements in the Sverdlovsk region. The review is conducted from the moment of development of the territory of the region in the 16th-17th centuries to the modern period. Factors of transformation of the network of urban-type settlements are singled out.
LAWS OF DIALECTICS AS APPLIED TO THE DIAGNOSIS OF THE STATE OF LIGHT INDUSTRY IN RUSSIA
Authors: Мария Александровна Поспишенко, , Татьяна Анатольевна Балина, , Зинаида Васильевна Пономарева,
Published: January 2023

Теоретическая и методологическая сущность диалектики делает ее инструментом практического преобразования общества, способствует учету исторических особенностей общественного развития при обосновании региональной политики в разных направлениях и на всех иерархических уровнях. Применение законов, принципов и категорий диалектики при географическом изучении видов деятельности дает философскую основу для анализа пространственной и структурной трансформации, имеет практическое применение для диагностики и прогнозирования их состояния в контексте мировых процессов. Принципы, законы и узловые категории диалектики дают возможность проанализировать особенности развития легкой промышленности России и ее регионов, выявить проблемы современного этапа развития, определить ее роль в формировании социоэкономики. Диалектический подход позволяет выявить общие и специфические черты российского производства на фоне кардинальных изменений мирового рынка производства и потребления товаров легкой промышленности, оценить возможности производства конкурентоспособной продукции в условиях санкций и политики импортозамещения.

The theoretical and methodological essence of dialectics makes it an instrument for the practical transformation of society, contributes to taking into account the historical features of social development in substantiating regional policy in different directions and at all hierarchical levels. The application of the laws, principles and categories of dialectics in the geographical study of activities provides a philosophical basis for the analysis of spatial and structural transformation, has practical application for diagnosing and predicting their state in the context of world processes. The principles, laws and key categories of dialectics make it possible to analyze the features of the development of light industry in Russia and its regions, to identify the problems of the current stage of development, to determine its role in shaping the socioeconomy. The dialectical approach makes it possible to identify the general and specific features of Russian production against the backdrop of fundamental changes in the world market for the production and consumption of light industry goods, to assess the possibilities for the production of competitive products under sanctions and import substitution policies.
STUDY OF THE CATALYTIC ACTIVITY OF IONIC LIQUIDS IN FRIEDEL-CRAFTS ALKYLATION REACTIONS
Authors: Олег Евгеньевич Журавлев, , Александр Алексеевич Арефьев,
Published: January 2023

В работе были получены ионные жидкости, обладающие кислотностью по Льюису. Изучена их каталитическая активность на примере алкилирования бензола дихлорметаном.

In the work, ionic liquids with Lewis acidity were obtained. Their catalytic activity was studied by the example of benzene alkylation with dichloromethane.
VERATROL PRODUCTION IN THE PRESENCE OF ZEOLITEBASED CATALYSTS
Authors: Валентина Сергеевна Носаева, , Антонина Анатольевна Степачёва,
Published: January 2023

Вератрол находит широкое применение в фармацевтической, пищевой, парфюмерной промышленности. Это соединение является полупродуктом во многих синтезах. Получение вератрола сопряжено с использованием токсичных и опасных компонентов. Это приводит к необходимости в трудоемкой очистке продукта. С целью снижения себестоимости и минимизации очистки многообещающим является применение гетерогенных катализаторов метилирования. В данной работе приводятся результаты исследования возможности синтеза вератрола из гваякола с использованием кислотных катализаторов ± цеолитов.

Veratrol is widely used in the pharmaceutical, food, and perfume industries. This compound is a semi-product in many syntheses. The production of veratrol involves the use of toxic and dangerous components. This leads to the need for time-consuming product purification stage. In order to reduce the cost and minimize purification, the use of heterogeneous methylation catalysts is promising. This paper presents the results of a study of the possibility of veratrol synthesis from guaiacol using acid catalysts ± zeolites.
STUDY OF THE KINETICS OF A ONE-POT REACTOR CELLULOSE CONVERSION PROCESS
Authors: Анастасия Евгеньевна Филатова, , Александрина Михайловна Сульман, , Елена Игоревна Шиманская, , Маргарита Александровна Монжаренко, , Ольга Валентиновна Гребенникова,
Published: January 2023

Полиолы являются веществами, крайне востребованными во многих отраслях современных химической, пищевой, парфюмерной, медицинской и топливной промышленностей. Их широко используют в производстве ПАВ, синтетических смол, лаков, олифы, витамина С, пищевых продуктов. В настоящее время усилия многих научных коллективов сосредоточены на разработке новых, эффективных и экологически безопасных способов получения полиолов из растительной биомассы, в первую очередь, из целлюлозы. Огромные природные возобновляемые запасы данного биополимера способны полностью удовлетворить потребности современной промышленности в полиспиртах, что особенно актуально с учѐтом перспективы постепенного истощения запасов углеводородных ископаемых. Одностадийный процесс конверсии целлюлозы до полиспиртов ( one-pot процесс), в присутствии гетерогенных металлосодержащих катализаторов известен достаточно давно, однако в литературе практически отсутствуют исследования, направленные на изучение его физико-химических основ и кинетики. Очевидно, что результаты таких исследований могут способствовать повышению эффективности процесса конверсии целлюлозы, стать фундаментальной основой новых, усовершенствованных технологий переработки целлюлозной биомассы в ценные химикаты.

Polyols are substances that are extremely in demand in many branches of modern chemical, food, perfume, medical and fuel industries. They are widely used in the production of surfactants, synthetic resins, lacquers, drying oil, vitamin C, food products. Currently, the efforts of many research teams are focused on the development of new, effective and environmentally friendly methods for obtaining polyols from plant biomass, primarily from cellulose. Huge natural renewable reserves of this biopolymer are able to fully meet the needs of modern industry in poly-alcohols, which is especially important given the prospect of gradual depletion of hydrocarbon reserves. The one-pot process of converting cellulose to poly-alcohols in the presence of heterogeneous metal-containing catalysts has been known for a long time, but there are practically no studies in the literature aimed at studying its physico-chemical bases and kinetics. It is obvious that the results of such studies can contribute to improving the efficiency of the cellulose conversion process, become the fundamental basis of new, improved technologies for processing cellulose biomass into valuable chemicals.
INTEGRAL ELECTRONIC CHARACTERISTICS OF DECANSULPHONE ISOMERS
Authors: Ирина Андреевна Нефедова, , Наталья Петровна Русакова, , Михаил Сергеевич Шостак, , Юрий Димитриевич Орлов,
Published: January 2023

Рассмотрено электронное строение пяти линейных сульфонов: метилнонилсульфона, этилоктилсульфона, пропилгептилсульфона, бутилгексилсульфона и дипентилсульфона в рамках «квантовой теории атомов в молекулах(QTAIM). Для групп СН, СН, S(O) рассматриваемых изомеров проведено сравнение зарядов, объемов и полной электронной энергии с аналогичными параметрами n декансульфона-1. Выявлена дальность влияния сульфонильной группы (S(O)) на интегральные электронные характеристики групп СН и СН. Составлена общая качественная шкала групповых электроотрицательностей.

The Quantum Theory of Atoms in Molecules (QTAIM) has been applied to study the electronic structure of five linear sulfones: methyl nonyl sulfone, ethyl octyl sulfone, propyl heptyl sulfone, butyl hexyl sulfone, and dipentyl sulfone. The topological groups CH, CH, S(O) were identified in the isomers; their charges, volumes, and total electron energy were compared with the analogous parameters of n-decanesulfone-1. The range of influence of the sulfonyl group on the integral electronic characteristics of methylenes and methyls was revealed. A general qualitative scale of group electronegativity has been compiled
Comparative In vitro Anti Inflammatory Study on Alpha Amyrin Isolated from Bark Extracts of Ficus benghalensis. Linn and Alstonia boonei. De Wild
Authors: Baburaj Ratna , V Sandur Rajendra , Das Kuntal
Published: January 2023

Background Ficus benghalensis and Alstonia boonei are two good sources of triterpenes like alpha amyrin and other bioactive compounds possessing anti-inflammatory activity.Objective The present study was conducted to compare the potential in vitro anti-inflammatory activity of alpha amyrin isolated from methanolic stem bark extracts of Ficus benghalensis Linn Fb and Alstonia boonei. De Wild Ab and to identify a better source for isolation of alpha amyrin.Methods The compound alpha amyrin was identified by Thin layer chromatography TLC method followed by Liquid chromatography mass spectrometry LCMS and Fourier transform infrared FTIR studies of the extracts and with High performance liquid chromatography HPLC determination. Furthermore the compound was studied for its in vitro anti-inflammatory effect by testing its role on inhibition of albumin denaturation anti-proteinase and anti-lipoxygenase activities and the results were compared with standard aspirin 100 microg mL.Results The results showed dose dependent activity in all the three in vitro models but showed non-significant variation among the isolated alpha amyrin from two different plants.Conclusion Amount of isolated alpha amyrin was higher in Fb source 0.42 mg than Ab plant 0.23 mg and hence Fb was identified as a better source for isolation of alpha amyrin for further investigations.