bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-social behaviour orders and young people with learning disabilities
Authors: Fyson Rachel , Yates Joe
Published: January 2011

This paper sets out to critically explore the use of anti-social behaviour orders (ASBOs) in relation to young people with learning disabilities. It brings together an emerging body of evidence, from a range of sources, which suggests that these marginalized and vulnerable young people are over-represented amongst those made subject to ASBOs. In this context it will provide a critique of existing practice, within both welfare and criminal justice agencies, which is typified by a lack of awareness and understanding of learning disability. Finally, it will suggest that the concept of diagnostic overshadowing may provide a useful way of thinking critically about current ASBO practice, and suggest that approaches which fail to address the underlying difficulties faced by young people with learning disabilities are unlikely to produce positive outcomes.
Such an easy ride for the new team
Authors: Moncrieff Chris
Published: January 2011

Why have the media failed to go to war on the coalition government? Because they've been outsmarted, believes the veteran political journalist, Chris Moncrieff. Fleet Street has not been able to find, or provoke, a civil war. He argues that despite the government's political diversity it is making far more of a success of protecting its own good name than New Labour ever did.
Twice-daily torture: volunteers needed
Authors: White Michael
Published: January 2011

Michael White has seen lobby spokesmen come and go during his 44 years covering politics for The Guardian. So who did the job best? Bland civil servants or "high octane politicos" like Alastair Campbell and Joe Haines? There are trade-offs, writes the ever diplomatic White in a deft look back through lobby history.
Juggling Family and Business
Authors: Heilbrunn Sibylle , Davidovitch Liema
Published: January 2011

This article investigates work–family conflict of women entrepreneurs in Israel. On the basis of the resource theory maintaining that class, ethnicity and gender interact in various combinations for different groups, the article explores factors influencing the intensity of work–family conflict of Arab, immigrant and Israeli-born Jewish women.2 Data were collected in 2007 through a questionnaire administered to a convenient sample of 111 women entrepreneurs in Israel. Degree of family support influenced intensity of the work–family conflict for all three groups of women entrepreneurs, but those from the Former Soviet Union (FSU) experienced the lowest intensity of the conflict, which can be explained in terms of particularities of gender status in their country of origin. Work—life balance remains a major issue for self-employed women.
Dehydrocoupling Reactions of Secondary and Primary Amine–Borane Adducts Catalyzed by Half-sandwich Carbonyl Complexes, [CpMn(CO)3], [(η6-C6H6)Cr(CO)3], and [CpV(CO)4]
Authors: Kakizawa Taeko , Kawano Yasuro , Naganeyama Kohsuke , Shimoi Mamoru
Published: January 2011

Dehydrocoupling reactions of amine–borane adducts catalyzed by half-sandwich carbonyl complexes are described. Secondary amine–borane adducts released H2 with catalytic action of [CpMn(CO)3] (Cp: η5-C5H5), [(η6-C6H6)Cr(CO)3], and [CpV(CO)4] under photoirradiation to produce dimeric or monomeric aminoboranes. These results were parallel to the [M(CO)6]-catalyzed system (M = Cr, Mo, and W); however, the reactions were considerably slower. Dehydrocoupling of BH3·NH2Me afforded an aminoborane polymer, [BH2NHMe]n.
Dual Dopable Poly(phenylacetylene) with Nitronyl Nitroxide Pendants for Reversible Ambipolar Charging and Discharging
Authors: Oyaizu Kenichi , Sukegawa Takashi , Nishide Hiroyuki
Published: January 2011

An electrode-attached layer of poly(phenylacetylene) bearing a pendant nitronyl nitroxide group per repeating unit, obtained by the Rh-catalyzed polymerization of 2-(4-ethynylphenyl)-4,4,5,5-tetramethylimidazoline-l-oxyl 3-oxide, underwent oxidation and reduction at 0.80 and −0.84 V vs. Ag/AgCl, respectively. The magnetically determined unpaired electron density of 92% was coulometrically reproduced, which supported the presumption that the radical survived during the course of the polymerization to allow both positive and negative charging of the pristine neutral polymer substantially per repeating unit. Galvanostatic Coulomb titration revealed the charge storage capability of the polymer, which demonstrated usefulness as organic electrode-active material with unprecedented ambipolar chargeability.
Stellettazole D, a Cytotoxic Imidazole Alkaloid from the Marine Sponge Jaspis duoaster
Authors: Sato Seizo , Iwata Fumie , Takeo Jiro , Kawahara Hiroyuki , Kuramoto Makoto , Uno Hidemitsu
Published: January 2011

A new cytotoxic imidazole alkaloid, stellettazole D, containing norsesquiterpene and aminopropylimidazolium units, has been isolated from the marine sponge Jaspis duoaster. The structure of stellettazole D was assigned on the basis of NMR, mass spectrometry, and IR spectral data. Stellettazole D has moderate cytotoxicity against a limited number of tumor cells.
New polyhedra – Part 3
Authors: Andersson Sten
Published: January 2011

We describe generalized polyhedra of icosahedron type with analytic mathematics (exponential summation method) using the ordinary (Platon and Archimedes) polyhedra and their interpenetrations (mixed polyhedra). To this we add the Hardy devation for enhancing the topology within each structure type. The findings are compared with the structures of some viruses.
Binding of Human Serum Proteins to Titanium Dioxide Particles In Vitro
Authors: Zaqout Mazen S.K. , Sumizawa Tomoyuki , Igisu Hideki , Higashi Toshiaki , Myojo Toshihiko
Published: January 2011

Binding of Human Serum Proteins to Titanium Dioxide Particles In Vitro: Mazen S.K. Zaqout, et al. Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan—

Objectives

To determine the capacity of human serum proteins to bind to titanium dioxide (TiO2) particles of different polymorphs and sizes.

Methods

TiO 2 particles were mixed with diluted human serum, purified human serum albumin (HSA) or purified human serum gamma‐globulin (HGG) solutions. After incubation at 37°C for 1 h, the particles were sedimented by centrifugation, and proteins in the supernatant, as well as those bound to the particles, were analyzed.

Results

The total protein concentration in the supernatant was lowered by TiO2, whereas the albumin/globulin ratio was elevated by the particles. Incubation with TiO 2 also lowered the immunoglobulin, pre‐albumin, beta2‐microglobulin, ceruloplasmin and retinol‐binding protein levels, but not ferritin levels, in the supernatant. After sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS‐PAGE),proteins in the supernatant, especially HGG, were observed to decrease, while those released from the particles (after adding 1% SDS and heating) increased, depending on the dose of TiO2 . Purified HGG and HSA were also bound to TiO 2, although the former appeared to have a higher affinity. All the proteins tested showed the highest binding potency to the amorphous particles (<50 nm) and the lowest to the rutile particles (<5,000 nm), while binding to anatase particles was intermediate. The affinity to the larger anatase was higher than that to smaller anatase particles in most cases.

Conclusions

Human serum proteins, including the two major components, HSA and HGG, are bound by TiO2 particles. The polymorph of the particles seems to be important for determining the binding capacity of the particles and it may affect distribution of the particles in the body.
Occupational Exposure to Phenolic Compounds at Coke Plants—Urinary Excretion of Methoxyphenols as an Indicator of Exposure to Methoxyphenols
Authors: Bieniek Grażyna , Stępień Krystyna
Published: January 2011

Occupational Exposure to Phenolic Compounds at Coke Plants—Urinary Excretion of Methoxyphenols as an Indicator of Exposure to Methoxyphenols: Grażyna Bieniek, et al. Department of Instrumental Analysis, Faculty of Pharmacy, Medical University of Silesia, Poland—

Objectives

This study describes the exposure of coke plant workers to methoxyphenols. The relationship between exposure to methoxyphenols and urinary excretion of metabolites was examined.

Methods

We determined concentrations of 2‐methoxyphenol, 2‐methoxy‐4‐methylphenol and 1‐(4‐hydroxy‐3‐methoxyphenyl) ethanone in the breathing‐zone air and in the urine of workers, collected after the workshift. Urine metabolites were extracted after enzymatic hydrolysis by solid‐phase extraction. Concentrations of methoxyphenols in air and urine were determined by gas chromatography with flame‐ionization.

Results

The time‐weighted average concentrations (median) of methoxyphenols in the breathing zone air were as follows: 9.9 ng/m3, 15.4 ng/ m3and 92.5 ng/m3for 2‐methoxyphenol, 2‐methoxy‐4methylphenol and 1‐(4‐hydroxy‐3‐methoxyphenyl) ethanone, respectively. The median values of urinary concentrations were as follows: 582.5, 190.1, 235.0 and 21.8 µmol/mol creatinine for 2‐methoxyphenol, 2‐methoxy‐4 methylphenol, 1‐(4‐hydroxy‐3methoxyphenyl)ethanone and 2,6‐dimethoxyphenol, respectively. A statistically significant correlation between the exposure level and the urinary level was found for 2‐methoxyphenol (r=0.573, p <0.01).

Conclusion

We found that the presence of 2‐methoxyphenol in urine can be used as a biomarker for 2‐methoxyphenol exposure. The analysis performed at the coke plant showed that the workers were exposed to relatively low concentrations of methoxyphenols.
Efficient in vitro propagation from preconditioned embryonic axes of Turkish cowpea (Vigna unguiculata L.) cultivar Akkiz
Authors: Aasim Muhammad , Khawar Mahmood , Özcan Sebahattin
Published: January 2011

Cowpea is an important grain legume crop. The study reports an efficient in
vitro multiplication and shoots regeneration protocol from preconditioned
embryonic axes of the Turkish cowpea cultivar Akkiz. The embryonic axes were
preconditioned with 10 mg/l BA on agar solidified MS medium for 5 days.
Thereafter they were cultured on MS medium containing 0.25, 0.50, 0.75 and
1.00 mg/l BA with or without 0.10 mg/l NAA. Mean frequency (%) of shoot
regeneration, number of shoots per explant and shoot length decreased with
each increase in BA concentration used singly. However, a positive increase
was recorded in all parameters in the presence of 0.10 mg/l NAA in the
regeneration medium. A maximum mean number of 10.33 shoots per explant was
recorded on an MS medium containing 1.00 mg/l BA -0.1 mg/l NAA. Regenerated
shoots were rooted on an MS medium containing 0.50 mg/l IBA. Rooted plants
were acclimatized at room temperature in soil mix contained in pots where
they were subjected to an intermittent mistwater spray for 24 h that
maintained 90% relative humidity during the first few days which was
gradually reduced to 40% for 10 days. All plants flowered and set seeds in a
greenhouse after 3 months.
Comparative analysis of populations of the Balkan endemic species Daphne malyana Blecic (Thymeleaceae)
Authors: Juskovic Marina , Vasiljevic P. , Randjelovic V. , Stevanovic V. , Stevanovic Branka
Published: January 2011

Daphne malyana Blecic (Thymeleaceae) is an endemic species of the western
part of the Balkan Peninsula, distributed in the mountains, canyons and
gorges of N. Montenegro, E. Bosnia and W. Serbia. The comparative
morphoanatomic investigations have included four distantly separated
populations of the species D. malyana, i.e. two from Serbia, from the ravines
of Sokoline and Vranjak on Mt. Tara, and two from Montenegro, in the canyons
of the Tara and Piva rivers. Comparative morphoanatomical studies have shown
the presence of general adaptive characteristics of a specific, conservative
xeromorphic type, slightly differing in each population. Principal component
analysis (PCA) and canonical discriminant analysis (CDA) of 20
morphoanatomical characteristics of the leaves and stems have shown a clear
distinction between the populations from the river Piva canyon (Montenegro)
and those from the Sokoline ravine (Serbia), on one side, and those of
Vranjak gorge (Serbia) and of the river Tara canyon (Montenegro) on the other
side. It may be assumed that the mild morphological variability of the
isolated populations of the Balkan endemic species D. malyana in the canyons
and gorges seem to have been affected by the microclimate conditions in their
habitats.
Chthonius (Chthonius) torakensis and Chthonius (Ephippiochthonius) cikolae, two new species of Psudoscorpions (Chthoniidae) from Croatia
Authors: Curcic B.P.M. , Radja T. , Dimitrijevic R.N. , Tomic V.T. , Pecelj M. , Curcic S.B.
Published: January 2011

Two new species of endemic and relict epigean dwellers of the genus Chthonius
C. L. Koch, have been described from Croatia. From its phenetically close
congeners (C. litoralis Hadzi and C. dalmatinus Hadzi), Chthonius (Chthonius)
torakensis n. sp. is distinguished in many important respects. In addition,
Chthonius (Ephippiochthonius) cikolae n. sp. (also from Croatia) differs from
its closest forms (C. (E.) lychidis Curcic and C. (E.) tetrachelatus
(Preyssler) by many morphological characters and form of different body
parts. Both species are illustrated, diagnosed and thoroughly described.
The influence of Carpathian landscape scale on spider communities
Authors: Urak I. , Hartel T. , Balog A.
Published: January 2011

In this study we evaluate the effect of traditional land use and landscape
change on the spider communities in the Eastern Carpathians, Romania. Three
sampling areas were selected along a gradient of mountain landscape within
the boundaries of the Olt river and the mountain zone from the Eastern
Carpathian region: forests, semi-natural habitats and extensively used
agricultural areas. Spider communities differed according to land use. The
highest species diversity was found in clearcut and orchards, whereas forest
habitats have less species richness and abundance.
New record of endangered red alga Bangia atropurpurea (A. Roth) C. Agardh (Bangiales, Rhodophyta) in the Nisava river, Serbia
Authors: Andrejic Jelena , Cvijan M. , Simic Snezana
Published: January 2011

Bangia atropurpurea was found at two new localities in the Nisava River
(Southern Serbia). In Serbia, this species is endangered. It has been found
so far in the Trgoviski Timok River, the Gvozdovacka River and the Raska
River. With the two new localities in the Nisava River, at present Bangia
occupies four rivers (five localities). New findings are important for the
protection of the biodiversity of red algal flora in the region, and provide
useful information on the ecological preferences of the species in Serbia.
A new Troglobitic pseudoscorpion (Pseudoscorpiones, Neobisiidae) from Istria, Croatia
Authors: Curcic B.P.M. , Radja T. , Dimitrijevic R.N. , Curcic S.B. , Milincic M.
Published: January 2011

A new endemic and relict species of the genus Neobisium Chamberlin, N.
mirkaci n. sp., from the Majhahlje Pit, Cicarija (Istria), Croatia, has been
described. From its phenetically close congeners, N. spelaeum Schiodte and N.
stygium Beier, it is distinguished in many important respects. This new taxon
is illustrated, diagnosed, and thoroughly described.
Basic protein structure prediction for the biologist: A review
Authors: Mihăşan M.
Published: January 2011

As the field of protein structure prediction continues to expand at an
exponential rate, the bench-biologist might feel overwhelmed by the sheer
range of available applications. This review presents the three main
approaches in computational structure prediction from a
non-bioinformatician?s point of view and makes a selection of tools and
servers freely available. These tools are evaluated from several aspects,
such as number of citations, ease of usage and quality of the results.
Finally, the applications of models generated by computational structure
prediction are discussed.
Hyperhomocysteinemia in patients with pulmonary embolism
Authors: Radovanovic N. , Antonijevic N. , Beletic A. , Perunicic J. , Kocica M. , Mirkovic D. , Lackovic Vesna , Lackovic Maja
Published: January 2011

Investigation of hyperhomocysteinemia (HHcy) as an important risk factor for
pulmonary thromboembolism (PTE), which represents a most dangerous
consequence of a unique phenomenon of venous thromboembolism which still
suffers from sometimes conflicting or inadequately clarified results. The
role of homocysteine in the clinical manifestation of this life-threatening
disease and its treatment (in which any further information may be decisive)
requires detailed examination. The purpose of this study is to determine the
differences in HHcy incidence and homocysteinemia levels between patients
with PTE and healthy persons. The study enrolled 70 patients with PTE and 50
healthy persons. Homocysteine was measured using the HPLC method with
fluorescent detection and HHcy was defined as homocysteinemia above 12
?mol/L. Statistical analyses included chi-square and Mann Whitney U tests.
The median homocysteinemia value was significantly higher (p=0.017) in the
patients (12.10 ?mol/L) than in the controls (10.35 ?mol/L). The comparison
of HHcy incidence between the patients (51.5%) and controls (30%) revealed a
significant difference (p=0.021). In patients, homocysteinemia was
significantly higher (p=0.002) in men (14.05?mol/L) than in women (10.01
?mol/L). HHcy was present in 67.6% of men with PTE, which was significantly
higher (p=0.006) than the incidence in women with PTE (33.3%). Healthy males
had significantly higher (p=0.001) homocysteinemia (12.54 ?mol/L) than
healthy females (9.4 ?mol/L). A significant difference (p=0.031) was observed
between the incidences of HHcy in healthy males (44.0%) and healthy females
(16.0%). We conclude that the incidence of hyperhomocysteinemia and
homocysteinemia are significantly higher in all the patients compared with
the healthy persons, as well as in both healthy males and males with PTE
compared with healthy females and female patients. This indicates that HHcy
findings in PE are likely to have a clinical importance.
Modeling the intercellular exchange of signaling molecules depending on intra- and inter-cellular environmental parameters
Authors: Balaz I. , Mihailovic D.T.
Published: January 2011

The exchange of biochemical substances is essential in establishing
communication between bacterial cells. It is noticeable that all phases of
the process are heavily influenced by perturbations of either internal or
external parameters. Therefore, instead of developing an accurate
quantitative model of substance exchange between bacterial cells, we are
interested in the formalization of the basic shape of the process, and
creating the appropriate strategy that allows further investigation of
synchronization. Using a form of coupled difference logistic equations we
investigated the synchronization of substance exchange between abstract cells
and its sensitivity to fluctuations of environmental parameters using methods
of nonlinear dynamics.
Genetic clues to the etiology of Balkan endemic nephropathy: Investigating the role of ACE and AT1R polymorphisms
Authors: Krcunovic Zorica , Novakovic Ivana , Maksimovic Nela , Bukvic Danica , Simic-Ogrizovic Sanja , Jankovic Slavenka , Djukanovic Ljubica , Cvetkovic Dragana
Published: January 2011

Balkan endemic nephropathy (BEN) was recognized as a distinct entity more
than 50 years ago, but the exact environmental and genetic causes of the
disease remain elusive. Considering the role of the renin-angiotensin system
(RAS) in the emergence of various nephropathies, in the present study we
evaluated the possible association with BEN of polymorphisms in two RAS
genes: I/D ACE (an angiotensin-converting enzyme) and A1166C AT1R (an
angiotensin type 1 receptor). The study groups consisted of 48 BEN patients
from the endemic region in the district of Kolubara, Serbia, 33 patients with
other nephropathies and 42 healthy individuals. The ACE DD genotype was
significantly more represented in the NBEN group (OR=5.447;
95%CI=1.862-15.932, p<0.01). The frequency of the AT1R CC genotype was higher
in BEN patients compared to controls (0.104 vs. 0.048), but the difference
was not significant. Though the analyzed polymorphisms are associated with
certain nephropathies, we found no support for their specific role in BEN
susceptibility.
The effect of aminoguanidine, an inducible nitric oxide synthase inhibitor, on AlCl3 toxicity in the rat hippocampus
Authors: Stevanovic I.D. , Jovanovic M.D. , Colic M. , Jelenkovic A. , Mihajlovic R. , Stojanovic I. , Ninkovic M.
Published: January 2011

The presented experiment was carried out to determine the effectiveness of
the inducible nitric oxide synthase inhibitor - aminoguanidine in modulating
the toxicity of aluminum chloride on the nitrite levels, malondialdehyde
concentration, reduced glutathione content, as well as cytochrome c oxidase
activity of Wistar rats. The animals were killed 3 h and 30 days after
treatment and the hippocampus was removed. The biochemical results show that
aluminum acts as a pro-oxidant, while aminoguanidine exerts an antioxidant
action in aluminum chloride-treated animals. We have also applied
immunohistochemical techniques to identify iNOS expression after the
treatment. Our data suggest that aminoguanidine can be effective in the
protection of toxicity induced by aluminum chloride.
In vitro production of human dermal equivalent
Authors: Milosavljevic Zoran , Ljujic Biljana
Published: January 2011

Introduction. Human dermal tissue is composed of loose and dense connective
tissue. Main cell populations are fibroblasts and the dominant fibers are
built from collagen type I. The aim of our study was to determine the precise
method and time frame for the in vitro production of human dermal equivalent
and to investigate the effects of ratio of structural elements and vitamin C
on characteristics of the engineered tissue. Material and methods. Primary
isolation of the foreskin fibroblasts was performed by explant method and
enzymatic dissociation. Various collagen gels were obtained by mixing cells
(from 25x103 to 200x103/ml) and neutralized collagen type I (from 2 to 4
mg/ml), with or without vitamin C. The routine histological and
morphometrical examination was performed. Results. Enzymatic dissociation of
the foreskin proved to be a faster method for production of desired number of
fibroblasts (7.5x105 for 4 days). The contraction of collagen-gels started
from day one through day seven and was dependent on cell and collagen
concentration with higher density gels being contracted to a greater extent,
except for the lowest/highest values. The best result was achieved with
100x103 cells and 2 mg/ml collagen. Vitamin C at 50 ?g/ml had no effect on
speed of tissue formation. Conclusion. A precise approach that mimic the in
vivo conditions is needed for the in vitro production of the dermal
equivalent suitable for the possible treatment of tissue defects. Nearly ten
days are necessary from the donor tissue dissociation to the final product.
Influence of hormonal therapy on the level of prostate specific antigen in patients with advanced prostatic cancer
Authors: Vojinov Sasa , Marusic Goran , Levakov Ivan , Popadic-Gacesa Jelena
Published: January 2011

% Karcinomi prostate % Antagonisti androgena % Kastracija % Testosteron % Luteinizirajuci hormone
AB Introduction. The aim of this study was to investigate the influence of
androgen blockades on prostate specific antigen (PSA) values in patients with
locally advanced and metastatic prostatic cancer. Material and methods. The
research was conducted on 60 patients. The group of 45 patients with
prostatic cancer was divided into 3 subgroups, based on the type of the
applied treatment protocol (15 patients on monotherapy with luteinizing
hormone-releasing hormone agonists, 15 patients on total androgen blockade
and 15 patients on monotherapy with antiandrogen). The control group
consisted of 15 patients with benign prostatic hyperplasia. For all patients,
the values of testosteron, luteinizing hormone and prostate specific antigen
were monitored before as well as after 3 and 6 months during the treatment
protocol. Results. All types of the applied treatment protocols in the
therapy of prostatic cancer decreased the values of prostate specific
antigen significantly The application of total androgen blockade and
monotherapy with luteinizing hormone-releasing hormone agonists decreased the
levels of prostate specific antigen significantly in comparison with
monotherapy with antiandrogen. Conclusion. Although prostate specific antigen
is not a prostatic cancer specific parameter, the dynamics of its decrease
during the therapy of androgen blockade represents a significant marker of
the therapy effect.
Cilj rada je bio da se ispita uticaj androgenih blokada na vrednosti prostata
specificnog antigena kod bolesnika sa lokalno uznapredovalim i metastatskim
karcinomom prostate. Ispitivani uzorak se sastojao od 60 bolesnika. Grupa od
45 bolesnika sa karcinomom prostate bila je podeljena na tri podgrupe, u
zavisnosti od primenjenog terapijskog protokola (15 bolesnika na monoterapiji
agonistima luteinizirajuceg rilizing hormona, 15 bolesnika na totalnoj
androgenoj blokadi i 15 bolesnika na monoterapiji antindrogenom). Kontrolnu
grupu cinilo je 15 pacijenata sa benignom hiperplazijom prostate. Svim
pacijentima su pracene vrednosti testosterona, luteinizirajuceg hormona i
prostata specificnog antigena neposredno pre, kao i tri, to jest sest meseci
nakon uvodjenja odgovarajuceg protokola. Sve tri vrste primenjenih terapijskih
protokola u lecenju karcinoma prostate statisticki su znatno snizavale
vrednosti prostata specificnog antigena u odnosu na pocetne vrednosti.
Primena totalne androgene blokade i monoterapije agonistima luteinizirajuceg
rilizing hormona dovela je do statisticki znatnog snizenja vrednosti prostata
specificnog antigena u poredjenju sa monoterapijom antiandrogenom. Iako
prostata specificni antigen nije specifican marker za karcinom prostate,
dinamika njegove promene u toku androgene blokade predstavlja bitan
pokazatelj terapijskog efekta.
Clinical and prognostic significance of CD34 expression in bone marrow biopsies in myelodysplastic syndrome
Authors: Savic Aleksandar , Rajic Nebojsa , Vlaisavljevic Nada , Cemerikic-Martinovic Vesna , Popovic Stevan
Published: January 2011

Introduction. The expression of CD34 antigen is increased in a substantial
portion of MDS patients, particularly in high risk patients, which was
associated with unfavorable survival in some studies. The aim of this study
was to determine the CD34 expression in bone marrow biopsies and its
prognostic significance in MDS patients and to analyze it in the context of
different clinical, laboratory and prognostic parameters. Material and
methods. The study was conducted in 53 MDS patients and 20 controls with
normal bone marrow. The CD34 expression was determined by CD34 monoclonal
antibody and labelled streptovidin biotin peroxidase method. The positivity
was determined by counting the 500 cells and it was expressed as percentage.
Results. Among the 53 MDS patients there were 37 males and 16 females with
average age of 62. The average CD34 expression in the MDS group was 1.37%,
the range being 0-8.8%, and in the control group 0.78%, the range being
0-1.60%. The difference was statistically significant (p<0.05). There was a
statistically significant difference in the CD34 expression comparing RA and
CMML group and high risk and low risk MDS (p<0.02). The median survival in
the patients with the CD34 expression with less than 2% was 22 months, while
it was 6 months in the patients with the CD34 expression over 2% (p<0.05). In
a multivariate analysis the CD34 expression together with the karyotype and
transfusion dependence had a statistical significance (p<0.05). Conclusion.
The CD34 expression in bone marrow biopsies is higher in the MDS patients
comparing with the controls as well as in high risk comparing with low risk
patients. The cutoff 2% seems to have a prognostic significance.
Choice of surgical suture material used in oral cavity: Clinical study
Authors: Mirkovic Sinisa , Djurdjevic-Mirkovic Tatjana , Bajkin Branislav , Sarcev Ivan
Published: January 2011

Introduction. Historical data on closing and suturing of surgical wounds
describe a wide range of various suture materials. The choice of the surgical
catgut, i.e. type and diameter, depends on the localization, characteristics
and condition of the tissue to be treated. From the stand-point of
oral-surgical practice the following clinical parameters are of the
outstanding importance regarding the choice of suture material: accumulation
of soft deposits on the sutures, decubitus of the adjacent soft tissues and
dehiscence of the operative wound. Aim. The aim of this research was to
determine the correlation between different types of suture materials and
accumulation of soft deposits on the sutures, decubitus of the adjacent soft
tissues and dehiscence of the operative wound. Material and methods. Our
prospective clinical study included 150 patients distributed into three
groups of 50 subjects. The surgical procedure performed on each patient
involved resection (apicoectomy) of the tooth root end in the intercanine
sector of the upper jaw. The following suture materials were applied: BLACK
SILK 5-0, NYLON 5-0 and VICRYL 5-0. The effects of the selected sutures were
evaluated by using several parameters: accumulation of soft deposits, wound
dehiscence and decubitus of the adjacent soft tissues. The effects of the
applied sutures were recorded on days 2, 5 and 7 after the surgery.
Conclusion. The comparison of cited parameters of the investigated materials
after suture of oral cavity mucosa revealed that none of the used material
was ideal; however, a certain preference might be given to the synthetic
monofilament suture materials.
Oxidation stress role in age-related cataractogenesis
Authors: Zoric Lepsa , Colak Emina , Canadanovic Vladimir , Kosanovic-Jakovic Natalija , Kisic Bojana
Published: January 2011

Introduction. Age-related cataract not only diminishes human life quality but
it also represents a big impact on healthcare budget of almost every country
as the population ages globally. Hence, cataract prevention is a big and true
challenge, but a very difficult task to be accomplished. Nowadays cataract is
more than a routinely recognized and almost always successfully operated
ophthalmologic disease. The diagnosis of age-related cataract diagnosis might
alert doctors to some systemic disorders on the whole body level. Increasing
age is certainly the most essential age-related cataract risk factor.
However, it seems that cataract could be a multifactor disease because of its
individual, familiar, racial and gender expression differences. Oxidation
stress. Oxidation stress and its form caused by ultraviolet
light-photo-oxidative stress - are considered to be crucial in the
etiopatho?genesis of cataract. All biomolecules suffer damages during
cataract formation. On the other side, the lens posses a range of antioxidant
elements and mechanisms of their action, which enable long lasting
maintenance of lens transparency and functioning. Although they are primary
characteristics of the lens, these antioxidant elements also depend on their
systemic availability and consumption. This paper is a short literature
review of the relation between oxidation stress and age-related cataract.
Seasonal variations: Risk factor of commiting suicide
Authors: Milic Caslav
Published: January 2011

Introduction. Suicide is a conscious and deliberate extermination of one?s
own life. Suicidal motives can be exogenous and endogenous. Exogenous factors
are those from social and economic sphere, moral and political ones. There
are numerous elements: demographic, socio-pathological,
clinical-psychopathological and, in recent time, seasonal variations and
meteorological characteristics are considered to be significant. Aim. On the
basis of the analyzed literature the aim of this paper was to show the
connection among seasonal variations, frequency and suicidal features.
Methods. Numerous epidemiological analyses of suicide have found a connection
between suicide and seasonal variations. The connection between seasonal
variations and suicide regarding the way of committing it (violent and
nonviolent one) has been checked. Seasons, particularly spring and summer,
have influence on suicide, which confirms the fact that suicide rate in time
corresponds with seasonal variations. Results. Suicides in younger age groups
of both sexes show smaller asymmetry in seasonal distribution than in older
groups. Seasonal influence on suicide rate has been proved to be bigger in
men than in women. As for the connection between seasonal characteristics and
suicide regarding the way of committing it (violent and nonviolent suicide)
most studies show that suicide, but only the violent one, is in direct
connection with seasons. Annual trend shows the peak from March to May (from
early to late spring) for violent suicide. Conclusion. To have knowledge
about the influence of seasonal variations on committing suicide is very
important for taking adequate preventive measures, especially in those
countries which have high rate of suicide.
Specific features of general anesthesia in stomatology fordisabled people
Authors: Turanjanin-Tomic Gordana , Draskovic Biljana , Stanic Danica , Uram-Benka Anna
Published: January 2011

Introduction. People who have either developed or acquired disability are the
patients with special needs. They often require general anesthesia for
stomatological interventions. These patients often develop a complex disorder
which interferes with a successful collaboration. General anesthesia should
be adapted to the kind and length of intervention, to the physical condition
of the patient and to the fact that majority of these interventions are
performed under the ?one day surgery? circumstances. The patient?s
preoperative preparation is of great importance. The anesthetics initially
used and those to maintain anesthesia must be short-lived with minimal
side-effects. The ?gold standard? for the airway protection is the
application of nasally placed endotracheal tubes, but the airway can also be
protected by orally placed endotracheal tubes as well as by armored version
of laryngeal mask airway during minor interventions. In the postoperative
period patients are given analgetics and other necessary symptomatic therapy.
The patient can be released no sooner than four hours after the end of the
operation. Conclusion. An appropriate preoperative preparation and the
selection of the adequate kind of general anesthesia result in a reduced
number of complications in this particular group of patients.
Importance of electromiographic examination in diagnostification and monitoring of chronic inflammatory demyelinating polyneuropathy
Authors: Damjan Igor , Cvijanovic Milan , Erak Marko
Published: January 2011

Introduction. Polyneuropathies or peripheral neuropathies present a
dysfunction or disease of larger number of peripheral nerves or their
dysfunction. Considering their morbidity - mortality characteristics they
present an important aspect in daily clinical practice. One particular
polyneuropathy that deserves special review is chronic inflammatory
demyelinating polyneuropathy, which, due to its clinical - laboratory
presentation, does not include the group of ?simple? neuropathies, thus
requiring further examinations. Neurophysiological testing should be
performed using the protocol for neuropathy examinations. Neurophysiological
examination, during the electroneurographic examination, shows neurographic
parameters referring to polyneuropatic demyelinating type of lesion, while
the electromyographic finding records the presence of neuropathic lesions
(denervation activity, great action potentials with a reduced sample). Case
report. A 54-year-old patient was diagnosed to have a ?complicated?
demyelinating polyneuropathy according to the clinical-laboratory findings
and electromyographic examination. Exclusion criteria, targeted diagnostic
examinations, considering the mentioned peripheral neuropathies, pointed to
acute inflammatory demyelinating polyneuropathy. However, the chronic
inflammatory demyelinating polyneuropathy was finally differentiated during
the clinical and electromyographic monitoring. Conclusion. The presented case
is interesting because it shows how one can ?wander? towards the diagnosis,
which is eventually made on the basis of electromyographic examination and
monitoring as well as according to exclusion criteria, which have
differentiated the acute inflammatory demyelinating polyneuropathy from the
chronic one.
Fungicide efficacy in peach rusty spot control in Serbia
Authors: Dolovac Nenad , Miletic Novica , Aleksic Goran , Savic Dusan , Zivkovic Svetlana , Trkulja Nenad , Bulajic Aleksandra
Published: January 2011

Rusty Spot has long been known as a harmful peach disease in many parts of
the world. During the past several years, rusty spot infection of the
late-maturing peach cultivars (Summerset, Suncrest, Fayette and O?Henry)
caused significant yield losses in Serbia. Although the etiology of the
disease is still unknown, there are numerous studies attempting to set a
strategy for its control and recommend appropriate chemical and other peach
protection methods. However, because of specific environmental conditions in
Serbia, recommended protection method using repeated fungicide treatments,
starting from petal fall, did not prove to be efficient and the rate of
infection in some susceptible peach cultivars reached 100%. In 2003 and 2004
a field trial was conducted in order to test the efficacy of fungicides (a.i.
kresoxim-methyl, flusilazole and sulfur) for the efficient control of Rusty
Spot epidemics. The trial was carried out under conditions of natural
infection on the peach cv. Summerset at the locality of Bela Crkva, Serbia.
In the untreated control plots, high disease incidence was recorded with the
percentage of affected fruit surface ranging from 33.5% in the first, up to
the 35.4% in the second year of the trail. Among fungicides included in the
trial, kresoxim-methyl proved to be the most efficient (90.25% in the first
and 91.12% in the second year of the trial), flusilazole exhibited lower
efficacy (87.28% and 80.61%, respectively) while sulfur was the least
efficient (82.33% and 80.30%, respectively). Determination of the most
efficient fungicide for the peach rusty spot control in Serbia provides basic
information for further investigations which will include optimization of
treatment terms, as well as additional agro-technical control measures.
Determination of allelopathic effect of some invasive weed species on germination and initial development of grain legume crops
Authors: Marinov-Serafimov Plamen
Published: January 2011

During the 2006-2007 period, the allelopathic effect of cold water extracts
from Amaranthus retroflexus L., Chenopodium album L., Erigeron canadensis L.
and Solanum nigrum L. on seed germination and initial development of Glycine
max L., Pisum sativum L. and Vicia sativa L. was studied under laboratory
conditions in the Institute of Forage Crops, Pleven. It was found that: water
extracts from fresh and dry biomass of A. retroflexus, Ch. album, E.
canadensis and S. nigrum had an inhibitory effect on seed germination of G.
max, P. sativum and V. sativa, the inhibition rate for the extracts from
fresh biomass varying from 28.8 to 81.5% and for the extracts from dry weed
biomass it was from 26.8 t? 89.2%; The values of LC50 varied from 13.5 t?
72.2 g l-1 for the extracts from fresh biomass and from 7.0 t? 84.1 g l-1 for
the extracts from dry weed biomass and they could be conditionally grouped in
the following ascending order: A. retroflexus < S. nigrum < E. canadensis
<Ch. album and for extracts from dry biomass: A. retroflexus < E. ?anadensis
< Ch. album < S. nigrum; P. sativum was the most sensitive to the
allelopathic effect of the extracts from fresh and dry weed biomass - LC50
varied from 13.5 t? 21.6 g l-1, followed by V. sativa - LC50 from 26.0 t?
11.7 g l-1 and G. max had relatively the lowest sensitivity - LC50 was from
46.6 t? 56.7 g l-1.
The effect of potato varieties on population of golden cyst nematode (Globodera rostochiensis)
Authors: Bacic Jasmina
Published: January 2011

The effect of susceptibility/resistance of seed potato varieties on
population of golden cyst nematode - Globodera rostochiensis (Wollenweber,
1923) Skarbilovich, 1959 was investigated in the infested field of Brdo, KO
Ljubovija No. 413, in Macva District in Serbia during 2002 and 2003. The
susceptible varieties Desiree, Innovator, Kennebec, Cleopatra, and Kondor
were used in the experiment as varieties frequently grown in this district.
The resistant ex-andigena varieties Agria, Frisia, Latona, Saturna, and
Tresor were chosen on the basis of identified pathotypes of G. rostochiensis
population originating from the aforementioned infested field. The results of
this research indicated that nematode population of G. rostochiensis could be
reduced and higher yield obtained by growing the resistant ex-andigena
varieties in case of presence of pathotype Ro1. In the second year of
investigation, final cyst density was 3.5 times lower than in the first year.
It subsequently affected the crop yield which increased in the second year.
The lowest crop yield was observed for susceptible varieties Kennebec (8.5
t/ha) and Cleopatra (16.9 t/ha), and the highest for resistant varieties
Agria (25.7 t/ha) and Frisia (29.1 t/ha). These results may be useful to
growers in the infested areas of Macva District when choosing potato
varieties, in order to eradicate the quarantine nematode G. rostochiensis.
Baby boom generation at the retirement onset
Authors: Stojilkovic Jelena
Published: January 2011

Sudden increase in the number of live births after the Second World War due
to an increase in fertility rates has led to the formation of cohorts with
specific characteristics or baby boom generation. This generation is unique
in the history of the demographic phenomenon that has affected and affects
the functioning of many segments of society. The aim of this paper is to
assess structure of baby boomers who are few years away from retirement,
using demographic data. Impact of baby boomer age structure of current and
future retirees is described with a graphical display of current and
projected age pyramid of baby boomers. Demographic pattern that women live
longer than men is evident in the projected pyramid. In addition, the number
of baby boomers will lead to a "younger" old population. The imbalance in the
number of men and women pensioners, as well as older cohorts of women and
female baby boomers was analyzed. As a result, an increasing trend of women's
age pensioners who are members of the baby boom generation was clearly
observed, which is opposite to the older cohort of women who often were
family pensioners. Different circumstances and conditions in which female
boomers lived and worked will form a new "pension model" because they will
gain their benefits as well as men, for the first time in significant number,
unlike their mothers, which gained the right to retire after they become
widows. Number of women age pensioners is getting greater comparing to men,
as the result of changes in the economic activities of women in the last half
of the 20th century. When baby boomers retire and exit the working
population, this will create a vacuum, because the numerically smaller
generations will enter working population, while the sudden and very shortly,
the number of population older than 60 or 65 will increase, most of them will
likely to acquire the right to a pension. It is undeniable that baby boomers
had impact on demographic structure, but also on society as a whole. They
have been extremely important factor of development of our country during
their working career, they are healthier then previous generation and many of
them possess the knowledge and experience gained by the years, so rigid
prediction of future changes that will produce the retirement of this
generation has no excuses. Retired baby boom generation will perhaps lead to
new, better way of life in old age.
Red blood cells transfusions in oncological patients treated with radio- and chemoterapy
Authors: Antic Ana , Stanojkovic Zoran
Published: January 2011

Background/Aim. Anemia is one of the most frequent hematology disorders in
patients with malignant diseases. It has a great influence on reduction of
the quality of life, so it requires early diagnosis and an adequate
treatment. The aim of this study was to present and analyze the treatment of
anemia using red blood cell transfusions in patients with malignancies, to
analyze adequate use of red blood cell transfusions according to hemoglobin
concentration, and also the influence of the treatment of malignant disease
on the level of anemia and use of red blood cells transfusion. Methods. This
retrospective analysis included the data on the use of red blood cells in
Oncological Clinic of Clinical Center Nis in a period from the 1st January
2008 to the 31st December 2008. Results. None of the patients received the
whole blood. In this period, 735 patients received 1,006 units of red blood
cells (red blood cell concentrate, resuspended, washed, filtered). An average
use of red blood cell transfusion was 1.37 unit per oncological patient who
received transfusion. The use of red blood cell units was adequate (87.60% of
patients received transfusion of red cells when Hgb < 80 g/L). During radio-
and chemotherapy we noticed a decrease of hematological parameter values. The
patients of the experimental group were dependant on red blood cells
transfusion. Statistically, a significant decrease of hemoglobin level was
observed in patients treated only with radiotherapy who are the greatest
consumers of red blood cells. Two patients were registered who more likely to
have febrile nonhemolytic transfusion reactions. Posttransfusion
alloimmunization occurred in 0.68% of the patients. Conclusion. The use of
red blood cells in oncological patients is in compliance with the up to date
tendencies and recommendations published in clinical guidelines. For the
purpose of efficient transfusion support in patients with malignant diseases,
we have to follow the newest knowledge and attitudes about clinical use of
blood products.