bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcome of Pediatric Comminuted Open Supracondylar Humerus Fracture
Authors: Kaganur Raghavendra , Regmi Anil , Paul Nirvin , Niraula Bishwa Bandhu , Sarkar Bhaskar , Singh Vivek , Maheshwari Vikas , Azam Quamar
Published: July 2024

Introduction:

Supracondylar humerus fracture is the most common fracture around the elbow in children. Closed fractures of the supracondylar humerus are ostensibly more common compared to open injuries. Though closed reduction and pinning are often feasible for Gustilo Anderson Grade 1 open fractures, surgical debridement followed by open reduction and pinning or JESS fixator application may often be required in open supracondylar humerus fractures with higher Gustilo Anderson grades.

Materials and Methods:

A retrospective study was conducted from 2018 to 2022 on children with open comminuted supracondylar humerus fractures. Open fractures were classified as per Gustilo Anderson’s classification, and fracture patterns were described as per modified Gartland’s and AO classifications. All patients were treated with closed or open-assisted reduction and fixation. Children were reviewed at the third/fourth and eighth weeks and later at 6 months and one year for the cosmetic and functional outcome assessment by Flynn criteria. Orthogonal elbow radiographs were obtained to assess radiographic parameters at each visit, including the final follow-up.

Result:

Six children with a mean age of 8.3 years (3–12 years) were treated during the study period. One child had grade 3A, two had grade 2, and three had grade 1 open fractures, according to Gustilo Anderson’s classification. The mean duration from injury to presentation was 36.3 h. The mean time from presentation to surgery was 3.3 h (1–5 h). The mean follow-up period was 9.6 months (6–12 months). Four children had excellent outcomes, whereas one child each had fair and poor results according to Flynn’s functional outcome criteria.

Conclusion:

Children with comminuted open supracondylar humerus fractures with an unusual mechanism of injury and presenting early since injury had better functional outcomes on follow-up as compared to children presenting late, with associated complications undergoing the same.
Nutrition optimisation of young tuberculosis patient with poor oral intake
Authors: Khairi Amir Imran Bin Mohd , Abdul Hamid Haslina Binti
Published: July 2024

A 19-year-old female teenager, Chinese, admitted to medical ward on 30 April 2023 with the reason of admission of recurrent disseminated pulmonary tuberculosis (TB) and presented with fever (2/12), cough (3/7), loose stool (1/12), shortness of breath (6/12), lethargy (2/52) and poor oral intake. She had underlying diseases of hypochromic microcytic anemia anaemia 2° iron-deficiency anaemia and folate deficiency, severe hypoalbuminaemia, hospital-acquired pneumonia due to Pseudomonas infection and persistent fever despite being on anti-TB medication. In this case, the patient had already been referred to a dietitian, but a follow-up was needed as she had a loss of appetite and inadequate oral nutrition for a few days. Her calculated body mass index is 16.1 kg/m2 (underweight) and Subjective Global Assessment (SGA) was rated with Grade B (mild-moderate malnutrition) with a history of severe weight loss for the past 1 month. The biochemical data showed abnormal readings of renal profile, albumin and haemoglobin levels.
Analysis of the physical morphology and athletic performance of local and naturalised players in the Chinese Super League
Authors: Feng Liangzhu , Gao Zhendong , Liu Yutong
Published: July 2024

Background:

The integration of naturalized players in Chinese soccer since 2019 has sparked significant debate, with mixed results raising questions about the effectiveness of this policy in improving the national team’s performance.

Objectives:

This study aims to analyze the differences in physical morphology and athletic performance between local and naturalized players in the Chinese Super League to assess the impact of naturalization on the national team’s competitiveness.

Methods:

Utilizing the AMISCO computerized tracking system, we collected and analyzed data from 561 matches spanning the 2019-2021 seasons. Employing mixed linear models, we examined the variance in key physical morphology and performance-related variables, with standardized differences assessed through Magnitude-Based Inference (MBI).

Results:

Our findings indicate modest but significant differences in physical morphology between local and naturalized defenders (P < 0.05, -0.32 < ES < -0.42). Performance-wise, naturalized defenders outperformed local counterparts in both technical and tactical aspects and demonstrated superior high-intensity running capabilities. Similarly, naturalized midfielders showed a slight edge over local midfielders in technical, tactical, and running proficiency. Conversely, local forwards exhibited marginally better technical and tactical performance compared to their naturalized counterparts, albeit with minimal differences in running ability.

Conclusion:

This study reveals that while naturalized players demonstrate certain advantages in physical morphology and athletic performance compared to local players in the Chinese Super League, these advantages are not consistent across all positions.
Posterior medial canthal thermoplasty in facial palsy: A simplified technique
Authors: Pallavi M. P. , Tara V. Shruthi , Rambhatla Saptagirish
Published: July 2024

Purpose:

The purpose of this study was to describe a new, simple, quick, reproducible, and minimally invasive surgical technique for medial canthal tendon (MCT) dehiscence and deformity in patients with facial palsy.

Methods:

A retrospective study of 10 patients having medial ectropion and MCT laxity in patients with facial palsy was included in the study. All patients underwent the simplified technique of posterior medial canthal thermoplasty and anchorage with 6/0 Vicryl. Ancillary procedures such as lateral tarsal strip, lower lid spacer, suborbicularis oculi fat lift, upper lid blepharotomy, and mullerectomy were also performed where warranted as a holistic treatment approach.

Results:

The study cohort included 10 patients. All patients had satisfactory outcomes concerning medial canthus position and lid-to-globe apposition. 9/10 patients had satisfactory punctum alignment.

Conclusions:

This technique is a safe alternate and reproducible procedure compared to the conventional open technique of anchoring the lid to the posterior lacrimal crest which is a challenging procedure even in experienced hands.
Clinical evidence of autologous platelet-rich plasma as treatment in macular holes
Authors: Saa David Paredes , Revelo Victor Andres Florez , Noguera Daniel Andres , Niño Vanessa Rangel
Published: July 2024

Background:

A prospective observational study was conducted with the purpose of evaluating the role of autologous platelet-rich plasma (PRP) in the form of a clot as an adjunct in surgery for the closure of large full-thickness macular holes (>400 μm).

Methodology:

Thirteen patients with a diagnosis of full-thickness macular hole larger than 400 μm, without associated pathologies or previous vitreoretinal surgeries, were selected. Each patient underwent a complete ophthalmological evaluation, including visual acuity (uncorrected or best corrected), optical coherence tomography (OCT Optovue), and in some cases, retinal photographs. On the day of the procedure, blood samples were taken to prepare PRP and form a clot according to institutional protocol. Patients were followed for 1 year with periodic evaluations that included OCT, retinal photographs, and assessments by a retina specialist and optometry.

Results:

Of the 13 patients, 46% (6 cases) had an epiretinal membrane as the triggering factor for the macular hole and 54% (7 cases) had vitreomacular traction. Complete closure of the macular hole was achieved in 92.31% (12 cases) and partial closure in 7.69% (1 case). Postoperative best-corrected visual acuity ranged from 20/30 to 20/200 according to the Snellen chart. No patient experienced a deterioration in visual acuity after the procedure.

Conclusions:

The use of PRP as an adjunct treatment for macular hole surgery in patients without previous vitreoretinal surgeries has proven to be effective in achieving complete or partial closure in a high percentage of cases. Pre-and postoperative changes in visual acuity, hole size, and type of closure provide valuable information on the efficacy of PRP treatment in these patients.
Prevalence of neurofibromatosis type 1 in patients presenting with neurofibromas of the eyelid and orbit
Authors: Kazmarek Elisa Moya , Burnier Victória de Lima , Bergeron Sabrina , Arthurs Bryan , Hadad Christian El , Mansure José João , Burnier Miguel Noel
Published: July 2024

Aims:

This study aimed to demonstrate the prevalence of neurofibromatosis type 1 diagnosis in patients presenting with neurofibromas of eyelid and orbit and the factors associated with this disease.

Materials and Methods:

Charts from patients with pathology reports of neurofibroma of the eyelid and orbit from the MUHC-McGill University Ocular Pathology Laboratory from 2007 to 2022 were reviewed to find information about clinical diagnosis of neurofibromatosis type (NF) 1, sex, age, presence of Lisch nodules, and other findings. The data were analyzed with the Chi-square test and Fisher’s exact test.

Results:

The prevalence of NF1 in patients presenting neurofibromas of the eyelid and orbit was 47.62% in the population studied. All patients with plexiform neurofibromas and all the ones presenting Lisch nodules had an NF1 diagnosis.

Conclusion:

All patients with plexiform neurofibromas of the eyelid or orbit and their relatives should be investigated for NF1. Ophthalmological evaluation is essential for the identification of Lisch nodules since their presence, associated with two neurofibromas are enough to meet the criteria for NF1; therefore, the family of patients with that presentation should be clinically, and if necessary, genetically tested.
Two cases of unilateral pediatric proptosis: A diagnostic challenge
Authors: Tara V. Shruthi , Pallavi M. P. , Thulasidas Mithun
Published: July 2024

Pediatric proptosis often presents with confusing clinical features requiring a systematic approach to avoid diagnostic dilemmas. We present two children of retinoblastoma and congenital uveal malignant melanoma, with late presentation. Through this article, we highlight the importance of systematic clinical examination, appropriate investigations for executing timely treatment, clinical correlation, and the value of histopathologic examination.
Reasons for parental refusal to provide consent in a pediatric randomized controlled trial: Lessons learned
Authors: Pasi Rachna , Babu Thirunavukkarasu Arun
Published: July 2024

BACKGROUND:

Results from randomized controlled trials (RCTs) are considered to have the highest level of evidence. Recruiting children for RCT is challenging and greatly influenced by the perception and decision of parents.

OBJECTIVES:

To find the reasons for refusal to participate in RCT.

DESIGNS:

Questionnaire-based qualitative study.

MATERIALS AND METHODS:

Parents who refused to participate in an RCT were asked to fill out the questionnaire, mentioning the reasons for the refusal.

RESULTS:

A total of 20 (14.8%) participants’ parent out of the 135 participants refused to participate in the trial. The age of participants who refused ranged from 6 weeks to 5 years old. We found that the reasons for refusal were as follows: 60.87% had apprehensions, 21.74% believed that pain pre-prophylaxis was unnecessary or preferred post-vaccination if needed, 8.69% refused because they had not received previous vaccinations, and 8.69% cited time constraints.

CONCLUSION:

Addressing the apprehension of parents in pediatric RCTs is crucial for reducing refusals. Non-placebo RCTs can be considered wherever feasible to address concerns about no drug administration to children.
The Effect of Lexical Accent on Perceived Japanese Vowel Length: Evidence from Croatian
Authors: Špica Dragana
Published: July 2024

The present paper examines the effect of Japanese lexical accent on the perception of Japanese vowel length in Croatian listeners. Lexical accent patterns of the two languages, both having phonologically distinctive length and pitch, are contrasted. A three-alternative choice identification test was conducted involving all combinations of three pitch patterns and two positions of a long vowel in bisyllabic words. Two groups of participants were Croatian students of Japanese and those without any prior knowledge. The results showed not only the effects of pitch pattern but also of the position of the long vowel (initial or final) and group. Participants had the highest error rates for pitch pattern LHL, followed by HLL, regardless of the group and position of the long vowel.
Pattern of Orofacial Clefts at A Tertiary Care Hospital in Ethiopia
Authors: Mekonen Eshete
Published: July 2024

BACKGROUND፡ Clefts of the lip and/or palate are the most common craniofacial birth defects. The worldwide birth prevalence is 1/700 live births. There are varying reports from Africa. This study investigated the patterns of orofacial clefts at a tertiary care hospital in Addis Ababa. METHODS: A retrospective descriptive study was performed to assess the patterns of Orofacial clefts at the main cleft care center in Ethiopia. The Data of cleft patients operated at the main cleft care center in Ethiopia from January 2007 to April 2020 with the support of Smile Train was used for this study. Their demographic and clinical data was retrieved from the Smile Train data base and analyzed using Stata version 16. RESULTS: A total of 1919 patients’ data was retrieved, excluding 16 patients’ data (.83%). The data of 1903 (99.17%) patients were enrolled in this study. Cleft lip and palate were found in 53.0% of the patients. Cleft lip only was found in 731 (38.4%) and cleft palate only in 166 (8.6%) patients. The commonest surgery performed was primary unilateral lip nose repair. Most patients were operated after the age of five years old. CONCLUSION: Many were operated after the age of five years, which is not in line with international recommendations. This needs improvement: establish more cleft care centers, distribute health care information and education.
Выявление дел, по которым возможно раннее урегулирование спора
Authors: Лазарев С.В.
Published: July 2024

ОДНУ ИЗ ПРИЧИН НЕЗНАЧИТЕЛЬНОГО КОЛИЧЕСТВА ДЕЛ, УРЕГУЛИРОВАННЫХ ПОСРЕДСТВОМ УТВЕРЖДЕНИЯ МИРОВОГО СОГЛАШЕНИЯ, АВТОР ВИДИТ В ОТСУТСТВИИ СРЕДСТВ ПО ВЫЯВЛЕНИЮ ДЕЛ, ПО КОТОРЫМ ВОЗМОЖНО РАННЕЕ УРЕГУЛИРОВАНИЕ СПОРА. В КАЧЕСТВЕ ТАКОГО СРЕДСТВА ПРЕДЛАГАЕТСЯ ИСПОЛЬЗОВАТЬ ВОПРОСНИК. ВЫЯВЛЕНИЕ ПРИ ПОМОЩИ ВОПРОСНИКА ВОЗМОЖНОСТИ РАННЕГО УРЕГУЛИРОВАНИЯ СПОРА ДОЛЖНО БЫТЬ ОСНОВАНИЕМ ДЛЯ ПРОВЕДЕНИЯ ПРИМИРИТЕЛЬНЫХ ПРОЦЕДУР. АВТОРОМ ПРЕДЛАГАЕТСЯ ВОЗЛОЖЕНИЕ НЕГАТИВНЫХ ПОСЛЕДСТВИЙ НА СТОРОНЫ В СЛУЧАЕ НЕПРЕДСТАВЛЕНИЯ ОТВЕТОВ НА ВОПРОСНИК.
Действие процессуального закона во времени в арбитражном процессе
Authors: Решетникова И.В.
Published: July 2024

В СТАТЬЕ РАСКРЫВАЕТСЯ ДОКТРИНАЛЬНЫЙ ПОДХОД К ОПРЕДЕЛЕНИЮ ДЕЙСТВИЯ ПРОЦЕССУАЛЬНОГО ЗАКОНА ВО ВРЕМЕНИ, СУЩЕСТВУЮЩИЙ НАЧИНАЯ С ХIХ В., А ТАКЖЕ СОВРЕМЕННЫЙ ВЗГЛЯД НА ЭТОТ ВОПРОС. СО ССЫЛКОЙ НА ПРАКТИКУ ВЕРХОВНОГО СУДА РФ АНАЛИЗИРУЮТСЯ ПРАВОПРИМЕНИТЕЛЬНЫЕ ПОДХОДЫ. ОТДЕЛЬНО АВТОР ОСТАНАВЛИВАЕТСЯ НА ОПРЕДЕЛЕНИИ АЛГОРИТМА ДЕЙСТВИЯ ЗАКОНА ВО ВРЕМЕНИ ПРИ ПРИНЯТИИ НОВОГО ЗАКОНА ПРИМЕНИТЕЛЬНО К ПОДАННЫМ, НО НЕ ПРИНЯТЫМ ЗАЯВЛЕНИЯМ И ЗАЯВЛЕНИЯМ, ОСТАВЛЕННЫМ БЕЗ ДВИЖЕНИЯ. АВТОР ТАКЖЕ АНАЛИЗИРУЕТ ВЛИЯНИЕ ПРЕДПОСЫЛОК ПРАВА НА ИСК НА ДАЛЬНЕЙШИЙ ПРОЦЕСС РАССМОТРЕНИЯ ДЕЛА. ФОРМУЛИРУЕТСЯ ВЫВОД О НЕОБХОДИМОСТИ В УНИФИЦИРОВАННОМ ПРАВИЛЕ ДЕЙСТВИЯ ЗАКОНА ВО ВРЕМЕНИ ПРИМЕНИТЕЛЬНО К ПОДАННЫМ, НО НЕ ПРИНЯТЫМ ЗАЯВЛЕНИЯМ И ЗАЯВЛЕНИЯМ, ОСТАВЛЕННЫМ БЕЗ ДВИЖЕНИЯ.
Social Capital, Culture, and Codes in Higher Education: Bourdieusian and Bernsteinian Philosophical Underpinnings in the South Africa Environment
Authors: Pietersen Doniwen , Tsotetsi Cias , Barnett Emma
Published: July 2024

Social capital ignored is an “object of political and ideological struggle” created to stifle working-class students in educational spaces. Furthermore, as societal dynamics are constructed in the student-lecturer relationship, this article seeks to evaluate how deliberative democracy in the online higher education space can inspire care through the ongoing dialogue between student and lecturer. This is framed against the Bourdieusian (social capital) and Bernsteinian (social code) framework because both theorists’ work highlights how the dominant class (represented by lecturers) consciously and unconsciously tends to ignore students’ social and cultural capital and codes. This, in turn, leads to a lack of dialogue and care in student-lecturer relationships in higher education. One of this study’s findings is that higher education is aimed to support more middle-class students. The reason for this is that our findings show that lecturers tend  not to know what to do with the social habitus of working-class or disadvantaged students. The aforementioned phenomena were foregrounded through Bourdieusian (social capital) and Bernsteinian (social code) model that is situated in the sociological approach, which is interpretive in nature, to explore whether dialogue and care were shown.
Pseudotumoral Testicular Tuberculosis: -A Potential Diagnostic Pitfall-
Authors: Allaoui Mohamed , Azzakhmam Mustapha , Oukabli Mohamed
Published: July 2024

Extrapulmonary presentation of tuberculosis TB is unfrequent, but testicular location is quite rare and can mimics testicular tumor. Herein, we report a case of a 50 years old man presented to urology department with a painless swelling of the left testis. Examination revealed a hard non tender mass of the testis that was initially managed as a testicular tumor, but later confirmed to be TB orchitis by histology. This report highlights the presentation similarity of the two entities, which may only be differentiated by histology therefore creating a diagnosis and managing challenge.

Keywords: Testis, Tuberculosis, Tumor
Assessing the Improvement of Geotechnical Properties of Clayey Soil Using a Substrate Cement Mortar Material, from Ilgin, Konya City, Turkey
Authors: Mohamed Ahmed , Saadi Saad , Gart Ibrahim , Mohammed Fahmy
Published: July 2024

The increase in needs and the decrease in places with good, usable foundation soil have made the construction of engineering structures on problematic soils mandatory. Problematic soils generally do not have sufficient bearing capacity and soil strength, which may create an environment prone to high settlement or liquefaction. To investigate potential ways to enhance the compaction, undesirable or problematic plasticity, and soil’s strength characteristics, various geotechnical tests have been carried out on clayey soils and their mixtures treated with a Substrate Cement Mortar (0, 4, 8, and 12% by weight). These tests involved Atterberg limits, dry density, compaction, and shear strength. The obtained results show that the addition of substrate cement materials increased the dry density of soil treated with SCM, which can significantly enhance the soil properties. Meanwhile, adding SCM decreased the soil's plasticity limits. Furthermore, adding 12% Substrate Cement Mortar resulted in the lowest optimum moisture content and the maximum dry unit weight. Soil treated with 12% also exhibits maximum cohesion and shear strength. This research led to the conclusion that the utilization of Substrate Cement Mortar additive is an inexpensive product and has significantly improved the soil’s geotechnical parameters.
Prevalensi Terjadinya Komplikasi pada Ibu Hamil dengan Infeksi Covid-19 Post Sectio Caesarea
Authors: Utami Nadila Rizqi , Herdiyantini Mita , Budiarti Retno , Harnanik Titut
Published: July 2024

Kehamilan merupakan periode pertumbuhan dan perkembangan janin disertai dengan perubahan fisiologis dan imunologis ibu sehingga lebih rentan mengalami infeksi, termasuk infeksi COVID-19. Kehamilan yang disertai dengan infeksi COVID-19 meningkatkan risiko terjadinya komplikasi terhadap ibu hamil. Penelitian ini bertujuan untuk mengetahui prevalensi terjadinya komplikasi post Section Caesarea pada ibu hamil dengan infeksi COVID-19. Metode pengambilan sampel menggunakan purposive sampling dengan melakukan pengamatan data rekam medis di RSPAL dr. Ramelan Surabaya periode Maret 2020 – Maret 2023. Dari total 100 sampel, terdapat 58 kasus yang terkonfirmasi COVID-19 dengan 8 kasus (32,0%) komplikasi kardiovaskular berupa 6 kasus (75,0%) komplikasi PPH dan 2 kasus (25,0%) komplikasi infeksi luka operasi. Prevalensi komplikasi pada saluran pernapasan didapatkan 13 kasus (52,0%) berupa 9 kasus (69,2%) komplikasi pneumonia dan 4 kasus (30,8%)  komplikasi ARDS. Komplikasi sepsis didapatkan 1 kasus (4,0%) dan 3 kasus (12,0%) komplikasi kematian pada ibu. Hasil analisis data mengunakan uji Koefisien Kontingensi menunjukkan nilai p-value = 0,001 (p < α). Terdapat hubungan antara infeksi COVID-19 dengan peningkatan prevalensi terjadinya komplikasi pada ibu hamil dan post Sectio Caesarea. Sehingga dalam penelitian ini didapatkan 25 kasus (43,1%) komplikasi post Sectio Caesarea pada ibu hamil dengan infeksi COVID-19 dan terdapat peningkatan prevalensi terjadinya komplikasi pada ibu hamil dengan infeksi COVID-19 post Sectio Caesarea.
Sintomas audiovestibulares em pacientes com Paquimeningite Hipertrófica Idiopática: revisão sistemática da literatura
Authors: Oliveira Rafaela Silva , Nascimento Eduarda Faria do , Feix Fabiana , Freitas Mariana de Albuquerque de , Ribeiro Amanda Victorya de Oliveira
Published: July 2024

Introdução: Paquimeningite hipertrófica é uma condição clínica com etiologias variadas, que incluem causas inflamatórias, infecciosas e até neoplásicas. A incidência é rara e atinge o espessamento difuso na camada meníngea dura-máter. Objetivo:  O objetivo dessa revisão foi apresentar os artigos publicados na literatura que abordassem os sintomas audiovestibulares nos casos de paquimeningite hipertrófica idiopática. Materiais e métodos: Este artigo de revisão foi elaborado a partir da consulta de artigos científicos de 1997 à novembro de 2021, referenciados na base de dados da Medline/PubMED e SciELO. Resultados e discussão: O diagnóstico é realizado pela avaliação clínica associado aos exames de neuroimagem, como tomografia computadorizada e ressonância magnética, se deve incluir o estudo histopatológico. As manifestações vestibulares são muito raras. A patogênese não é clara. A principal causa da perda auditiva e dos sintomas vestibulares pode ser o aprisionamento do nervo no canal auditivo interno com dano neuronal secundário. Os pacientes apresentavam perda auditiva neurossensorial uni ou bilateral. Nestes casos, o tratamento utilizado foi o corticoide, com melhora em 87,5% dos pacientes.  Considerações fianis: A descompressão cirúrgica pode ser uma das opções terapêuticas, se necessário aliada ao uso de imunossupressores para reduzir as sequelas otoneurológicas nesses pacientes.
Otoritas Alkitab: Tinjauan Teologi Sistematis Pemikiran Luther Menjawab Skeptisisme Teologi Kontemporer Tentang Alkitab Sebagai Firman Allah
Authors: Sitompul Victor Golan , Rinaldi Girsang  , Insan Sinurat
Published: July 2024

The purpose of writing this article is to explore Martin Luther's view of the Bible as the authoritative Word of God as a critical answer to the doubts of contemporary groups. This article refers to the results of Luther's thoughts in documents and systematic theology classroom notes. The meaning of what and how the Bible is for Luther is the most fundamental thing that is intertwined with history, travel, and church growth. By using library research methods, the author finds Luther's critical thoughts regarding the Bible his criticism of the Roman Catholic Church, to the doubts of contemporary groups regarding the Bible which is understood as God's Word in all centuries throughout life.
Morphological characteristics of the cerebral cortex of a mini-pig under conditions of gene therapy after experimental stroke
Authors: Safiullov Z. Z. , Izmailov A. , Markosyan V. A. , Khomyakov A. E. , Boychuk N. V. , Nigmetzyanova M. V. , Siraeva A. R. , Targachev S. S. , Valiullin V. V. , Islamov R. R. , Pospelov V. I.
Published: July 2024

Aim.To study the effectiveness of preventive gene therapy (within 2 days) and gene therapy in the acute phase (after 4 hours) of ischemic stroke in mini-pigs using an autologous leucoconcentrate (AutoLeuc) enriched with recombinant genes of vascular endothelial growth factor (VEGF165), glial cell line-derived neurotrophic factor (GDNF) and neural cell adhesion molecule 1 (NCAM1), as well as the migration of leukocytes transduced with a chimeric adenoviral vector serotype 5 with fiber 35 serotype (Ad5/F35) and the green fluorescent protein (GFP) genome into immune defense organs.

Materials and methods.The experiment was conducted on 8-month-old Vietnamese lop-bellied mini-pigs (n=16). An ischemic stroke was created by occlusion of the distal branches of the left middle cerebral artery and the right common carotid artery. Genetically modified AutoLeuc was administered preventively intravenously 2 days before or in the acute phase 4 hours after stroke modelling; the control group was injected with 30 ml of saline solution. The morphology of the cerebral cortex was assessed using histological methods in the areas bordering the infarction and peri-infarction after 21 days. The migration of genetically modified Ad5/F35-GFP leukocytes into the brain, spleen, and submandibular lymph nodes was studied a week after stroke modelling.

Results.In the peri-infarction zone, the content of pyknotic neurons in control animals was higher, while the number of capillaries was lower than in the gene therapy groups. In the latter, neurons had a typical morphology with preserved outgrowths; in the control group, the outgrowths were tortuous and fragmented. Fluorescence microscopy after injection of AutoLeuc with Ad5/F35-GFP revealed GFP-positive cells in the spleen and submandibular lymph nodes.

Conclusion.21 days after modeling a stroke in mini-pigs against the background of preventive gene therapy or gene therapy in the acute phase using VEGF165/GDNF/NCAM1 AutoLeuc, greater preservation of neurons and a higher density of capillaries in the peri-infarction zone of ischemic brain damage were established. Leukocytes with Ad5/ F35-GFP were found in the spleen and submandibular lymph nodes.
Basic aspects of meta-analysis. Part 2
Authors: Tao E. A. , Nadinskaia M. Yu. , Suvorov A. Yu. , Bulanov N. M. , Sholomova V. I. , Potapov P. P. , Taratkin M. S. , Brovko M. Yu.
Published: July 2024

Meta-analysis combines the results of several scientific studies to obtain a summary quantitative estimation of effect size in order to compare the results of several studies and to identify patterns among them and possible sources of biases. Since the research teams, patients, research protocol, clinical guidelines and time intervals are often different between original scientific studies all these sources of difference can influence the results of each study, causing statistical heterogeneity. Meta-analyses are the highest level of credibility within evidence-based medicine, as they allow us to take into account the influence of many confounding factors and publication biases on the true effect size. Understanding the possible sources of erroneous conclusions in papers will allow researchers to analyze the results of such studies correctly and properly plan their own experiments. In this article the reader will be introduced to methods for identifying and quantifying hidden heterogeneity, such as subgroup analysis and meta-regression. In addition, the reader will learn how to calculate effect size in studies, estimate publication bias mathematically and graphically, and incorporate this estimate into the overall average effect size estimate in meta-analyses.
The Impact of Selected Financial Ratios on The Market Performance of Listed Companies on The Acceleration Board Indonesia Stock Exchange (Period 2020-2023)
Authors: Puspita Inaya ,   School of Business and Management, Bandung Institute of Technology, Indonesia, Soekarno Subiakto ,   School of Business and Management, Bandung Institute of Technology, Indonesia
Published: July 2024

This research aims to analyze the impacts of selected financial ratios on the market performance of listed companies in the Acceleration Board IDX (Period 2020-2023) and find if IDX need to add the financial requirements in IDX Listing Regulations no. I-V to increase the company’s market performance in Acceleration Board IDX. The data of selected financial ratios and market performance were collected from the publication of listed companies’ financial reports and market trading data in 2020-2023 that can be accessed publicly on IDX’s official website. The population in this research is the whole Acceleration Board listed companies that were listed in IDX from 1st January 2020 – 31st December 2023. The samples used are limited to companies listed in Acceleration Board IDX period 2020-2023. Multiple regression analysis is used in this research to examine the relationship between the dependent variable and two or more independent variables. From five independent variables, partially, only the Net Profit Margin has a significant impact on the company’s market performance (stock price). From the results of the ANOVA test, there is a simultaneous significant effect of the independent variables ROA, ROE, DER, NPM, and Cash Flow from Operation on the dependent variable Market Performance (stock price).
Franchise Potential in Food Industry Expansion Strategies in East Kalimantan
Authors: Naufal Farizan ,   School of Business Management, Bandung Institute of Technology, Indonesia, Hermanto Ruby , Sarjono Putro Utomo ,   School of Business Management, Bandung Institute of Technology, Indonesia,   School of Business Management, Bandung Institute of Technology, Indonesia
Published: July 2024

This study investigates the franchise potential in the food industry as part of expansion strategies in East Kalimantan, with a focus on the Wong Solo Group amid Indonesia’s capital relocation. Utilizing qualitative methods, including SWOT, PESTLE, Porter’s Five Forces, and the VRIO framework, the research provides a comprehensive analysis of strategic positions and opportunities for business expansion. The study reveals significant opportunities for growth driven by demographic changes, economic development, and increased consumer spending. Key findings indicate that Wong Solo Group’s established brand and operational expertise offer a strong foundation for expansion. However, challenges such as regulatory changes and intense competition need to be addressed. The SWOT analysis highlights internal strengths such as brand reputation and product innovation, while the PESTLE analysis underscores external opportunities and threats. Porter’s Five Forces analysis identifies competitive pressures within the food industry, and the VRIO framework assesses the group’s resources and capabilities. The study concludes with strategic recommendations for Wong Solo Group to leverage its strengths, address its weaknesses, capitalize on opportunities, and mitigate threats. These recommendations aim to ensure successful franchise expansion in the dynamic market environment of East Kalimantan, providing a roadmap for sustained growth and competitive advantage.
Developing Students’ Speaking Skill Through Digital Storytelling
Authors: Hidayat Amrul , Thamrin Sri Wahyuni , Anugrah M Andi , Wahidah Z St.
Published: July 2024

Students’ speaking ability of the eleventh grade at Pondok Pesantren Abu Bakar Ash-Shidiq was still classified as low. Therefore, it is necessary for the researcher to conduct the research in order to give significance theortically and practically. Theoretically, the result of this study was expected to support or refine the theory of EFL and ESL teaching. And, practically it is essential for those English teachers in designing a classroom activity to help the learners speak in English more accurately and fluently. This research aimed at finding out the improvement of the students’ speaking skills by using Digital Storytelling at the Eleventh Grade of Pondok Pesantren Abu Bakar Ash-Shidiq Taccorong. This research used pre-experimental method with 15 students of the eleventh grade of Pondok Pesantren Abu Bakar Ash-Shidiq Taccorong as the sample which was taken purposively from 32 as the population. The research findings showed that the mean score the value of post-test is higher than the pre-test’s value; 70,6>50,6. Furthermore, the t-test value of each speaking aspect and combination of aspects found were all higher than the t-table; 5.69>2.145, 4,65>2.145, and 11,8 > 2.145. The statistical research result indicates that the null hypothesis was rejected and the alternative hypothesis was accepted. Therefore, it can be concluded that digital storytelling improved the students’ speaking ability
Nilai Nasionalisme dan Religiusitas dalam Cerita Rakyat Ki Gede Sebayu
Authors: Selviana Nurhikmah  , Bambang Sulanjari  , Nuning Zaidah
Published: July 2024

The Ki Gede Sebayu folktale was one of the most renowned stories from Tegal and one of the founding figures of Tegal city. This study aimed to examine the depiction of nationalism and religiosity values in Ki Gede Sebayu folklore through three main aspects: infrastructure development, the role of religion, and community capacity building. A descriptive-qualitative approach was employed, with data collected through literature study and directed observation and analyzed using Levi-Strauss structuralism theory. The results indicate that the folklore of Ki Gede Sebayu reflected a number of values associated with nationalism, including love for the country, togetherness, mutual cooperation, courage, sacrifice, social justice, loyalty to the country, and exemplary leadership. Additionally, the value of religiosity is reflected through the spread of Islamic propagation as well as the construction of mosques and Islamic boarding schools. The conclusion of the Ki Gede Sebayu folklore was that it reflects the values of nationalism and religiosity. As a result, it was an important source of inspiration in the construction of the unity and pride of the Indonesian nation.
Beyond the Policy: An Ethnographic Exploration of IKSP in Philippine Practice
Authors: Guzman Ma. Teresa G. De
Published: July 2024

Indigenous Knowledge Systems and Practices (IKSP) have gained significant attention over the past decade, moving from the periphery to the forefront of sustainable development discussions. Until recently, there was limited evidence to support the effectiveness of IKSP-based interventions. However, since the early 1990s, research in this field has flourished, resulting in a substantial body of information that addresses various aspects of IKSP. Despite this progress, the field remains in its early stages, and there is a scarcity of reliable sources that can compile and integrate this vast body of knowledge, making it more accessible and valuable. This paper provides a concise and comprehensive overview of IKSP research and assessment, heavily relying on field cases and current theory and practice discussions. By examining thriving agricultural, health, and environmental conservation interventions among indigenous communities in the Philippines, the paper highlights the practical benefits of IKSP. For instance, the Ifugao rice terraces illustrate sustainable agricultural practices, while traditional herbal medicine and integrated health practices demonstrate the value of indigenous health systems. Environmental conservation efforts, such as the Aeta’s fire management techniques and the T’boli’s sustainable fishing practices, further underscore the importance of IKSP. The paper also incorporates a wealth of literature, including research findings from the first, second, and third International IKSP Conferences sponsored by the University of the Philippines, Manila, and the University of Ahmad Dahlan. These findings present critical positions advanced by indigenous peoples, helping to improve the design, delivery, monitoring, and evaluation of research programs for IKSP. The recommendations aim to enhance the integration of IKSP into formal education systems and policy-making processes, thereby promoting cultural preservation and environmental sustainability. By thoroughly synthesizing existing research and practical examples, this paper contributes to the growing recognition of IKSP as a vital component of sustainable development strategies, fostering resilience and well-being in Indigenous communities.
Leveraging AI-Driven IoT Systems for Enhanced Air Quality Management in Nigeria: An Impact Examination towards Sustainable Development Goal
Authors: Jacinta Chioma Odirichukwu , Chimaobi Odirichukwu Simon Peter , Adiele Okolie Stanley , Athanasius Njoku Obilor
Published: July 2024

This paper conducts a comprehensive analysis of the impact of Artificial Intelligence (AI)-driven Internet of Things (IoT) systems on air quality management in Nigeria. The study examines the current state of air quality in Nigeria, highlighting prevailing challenges, health implications, and the environmental significance of escalating pollution levels. It delves into the existing conventional methods and technologies utilized for air quality management, emphasizing monitoring systems, regulatory frameworks, and pollution control measures. In addition, this review elucidates the integration of AI and IoT technologies globally in addressing environmental concerns, particularly in the realm of air quality management. It specifically zooms into the emergence and adoption of AI-driven IoT systems within Nigeria’s environmental landscape, spotlighting ongoing initiatives or projects. This review seeks to investigate the implementation and consequences of AI-powered Internet of Things (IoT) systems in air quality management within Nigeria context. It bridges existing knowledge gaps by scrutinizing the effectiveness of these advanced systems in mitigating air pollution and assesses the challenges encountered in practical implementation, encompassing technical, regulatory, and socio-economic barrier.
Diseño y validación de contenido por juicio de expertos de un instrumento para evaluar la efectividad del proceso educativo relacionado al emprendimiento en estudiantes de educación superior
Authors: GARCIA Ana L. ,   Universidad Tecnológica de Tulancingo, CORONA Katia , HERNANDEZ Maria E. , HERNANDEZ Rabindranath , VILLALPA Hugo ,   Universidad Tecnológica de Tulancingo,   Universidad Tecnológica de Tulancingo,   Universidad Tecnológica de Tulancingo
Published: July 2024

El propósito de la presente investigación fue diseñar y validar un instrumento que permitiera conocer la efectividad del proceso educativo relacionado al emprendimiento social que los estudiantes de nivel superior adquieren durante su formación académica. Para esto se realizó la revisión documental del tema y la siguiente etapa consistió en diseñar un instrumento considerando cuatro dimensiones que permitieron medir el planteamiento del constructo y para garantizar el contenido. Se realizó validez de facie por tres expertos en el tema y una vez observado el instrumento se procedió a una evaluación por parte de un grupo de diez jueces expertos, la validez de contenido arrojó un valor cuantitativo de acuerdo con el coeficiente V de Aiken (V>0.80) en los ítems 5,6,7,8,9,10,12,13,14,15,16,18,19 y 20, caso contrario (V<0.80) en los ítems 1,2,3,4,11 y 17. Esta validez permitió mejorar y corregir la pertinencia y consistencia del instrumento para posteriormente realizar una prueba piloto. Los resultados de la prueba piloto aplicada a un grupo de veintidós estudiantes de una universidad tecnológica, arrojó una confiabilidad mediante Alfa de Cronbach de 0.901, lo que permite inferir que el instrumento es confiable.
Análisis de actuaciones en la zona agrícola de las cuencas Sur del Mar Menor con el objetivo de mejorar el estado ecológico de la laguna
Authors: Puertes Cristina , Sepúlveda Juan Francisco , Lidón Antonio , Francés Félix
Published: July 2024

La agricultura es una de las principales fuentes de contaminación difusa, cuya contaminación por nitrógeno y sedimentos de las son los principales impactos ambientales. Es por ello, que una adecuada gestión de estas zonas es necesaria. El presente estudio se llevó a cabo en la cuenca más meridional del Mar Menor, que se encuentra amenazado por la exportación difusa de nutrientes y sedimentos. Es por ello que este estudio evalúa la efectividad de varias actuaciones basadas en la Ley 3/2020, de recuperación y protección del Mar Menor para el control de las descargas de nitrógeno y sedimentos a la laguna. Los resultados de estas simulaciones mostraron que con el cumplimiento completo de la Ley 3/2020 es posible reducir de forma significativa la producción de sedimentos a la laguna, así como la exportación de nitrógeno en superficie y la lixiviación de nitratos.
Mitigación mediante bacterias, hongos y organismos superiores de los impactos ambientales ocasionados por microplásticos en ecosistemas acuáticos
Authors: Newrick Bess Alicia , Laca Pérez Amanda , Laca Pérez Adriana
Published: July 2024

Debido a su durabilidad, versatilidad y bajo coste, los productos plásticos resultan fundamentales en la sociedad actual; sin embargo, estas mismas propiedades, responsables de su gran popularidad, también convierten a estos materiales en una amenaza medioambiental, provocando serios problemas entre los que destaca la liberación de microplásticos (MPs). Los MPs, definidos como partículas poliméricas con un tamaño inferior a 5 mm, son muy diversos en cuanto a composición, tamaño y forma, siendo capaces además de transportar sobre su superficie otros contaminantes y microorganismos, lo que incrementa los potenciales efectos adversos de estas micropartículas. Aunque los MPs se encuentran de manera ubicua en todo el planeta, su presencia es notoria en los ecosistemas acuáticos, especialmente los marinos, ya que las masas de agua naturales reciben la gran mayoría de los plásticos vertidos al medioambiente. Recientemente, la biorremediación ha sido propuesta como una interesante alternativa para luchar contra la creciente problemática derivada de la contaminación plástica; por ello, el objetivo de la presente revisión bibliográfica es analizar las posibles vías de eliminación de los MPs de origen fósil y no biodegradables en entornos acuáticos, mediante bacterias, hongos y organismos superiores, recopilando los últimos avances en este campo.
Cálculo de la evolución espacio-temporal de la recarga al acuífero cuaternario del Campo de Cartagena (SE España) desde 1970 a 2022
Authors: Alcaraz Mar , Polo María José , Hornero Jorge , Jiménez-Martínez Joaquín , Alcolea Andrés , Manzano Marisol
Published: July 2024

Los objetivos del trabajo son evaluar la evolución temporal y espacial de la recarga al Acuífero del Cuaternario del Campo de Cartagena desde 1970 a 2022 y generar mapas de entrada para un modelo numérico de flujo de agua subterránea. Para alcanzarlos se han recopilado datos meteorológicos, se ha compilado y contrastado la información disponible sobre los usos de suelo, poniendo especial atención en la evolución temporal de la distribución espacial, se ha calculado la recarga con el software VisualBALAN y se han generado mapas de recarga que reflejan la evolución espacial y temporal durante el periodo simulado, con el apoyo de QGIS. La recarga calculada se ha calibrado y validado con éxito con series piezométricas temporales. La recarga total media calculada es 91 hm3 año-1 para todo el periodo; los valores extremos son 24 hm3 en 1978 y 172 hm3 en 2008. Esto se traduce en un coeficiente de recarga promedio del 16%, un valor mínimo del 8% y un máximo del 24%.
Cuerda que Desliza sobre una Mesa: Modelo Complejo vs. Modelo Simple
Authors: Cabral-Rosetti Luis G. , Castillo Rosas Adriana
Published: July 2024

En la Enseñanza de la Dinámica Newtoniana a nivel universitario solemos construir Modelos Mecánicos para la comprensión de la situación Física estudiada. Por lo regular construimos primeramente modelos simples (toy models) que posteriormente iremos sofisticando con la intención de crear un modelo más complejo y por tanto más realista al final. Aseguramos con ello que el modelo sofisticado es mejor que el modelo simple (Estrategia de Modelización Progresiva, EMP). ¿Esto es siempre así?. Presentamos aquí la construcción de Dos Modelos Mecánicos (uno Sofisticado y otro Simple) para estudiar el Movimiento de una Cuerda Masiva que Resbala sobre una Mesa con y sin Fricción Seca y mostramos que los principales resultados obtenidos en el modelo simple son tan buenos y generales como los obtenidos del modelo sofisticado. Lo anterior nos muestra como poder estudiar el problema de la Cuerda que Desliza por una Mesa en diferentes estadios de la Educación Universitaria sin detrimento de la compresión completa del problema planteado. Como complemento a lo anterior discutimos también la versión Lagrangiana del Problema, así como una posible generalización al problema planteado.
Estudio del interferómetro de Michelson mediante un laboratorio virtual
Authors: Muñoz-Pérez Francisco M. , Monsoriu Juan A. , Ortega Mendoza J. Gabriel
Published: July 2024

La interferencia es un fenómeno de la física de ondas que se produce cuando dos o más ondas se superponen. En el caso de la interferencia de la luz, esto resulta en patrones de luz y sombra. En este trabajo, presentamos un laboratorio virtual desarrollado como interfaz gráfica de usuario (GUI) en el software Matlab. que tiene como propósito facilitar el estudio del fenómeno de interferencia de la luz para diferentes longitudes de onda. La meta principal es proporcionar a los estudiantes de asignaturas de Física y Óptica, tanto a nivel de pregrado como de grado, las competencias necesarias para comprender el comportamiento ondulatorio de la luz a través del análisis del patrón de interferencia generado.
Síndrome de Burnout em Psicólogos Clínicos: Um modelo Demandas-Recursos
Authors: Marques Vanessa da Silva , Carlotto Mary Sandra
Published: July 2024

Psicólogos clínicos tem sido considerados categoria de risco de desenvolver a Síndrome de Burnout. Com base no modelo de Demandas-Recursos, este estudo teve como objetivo verificar se a Inteligência emocional e a Autoeficácia profissional desempenham um papel mediador entre o Trabalho emocional e a Síndrome de Burnout em uma amostra de 240 psicólogos clínicos brasileiros. Os dados foram coletados por meio de plataforma on-line, tendo como instrumentos de pesquisa um questionário de dados sociodemográficos e laborais, o Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo, o Questionário de avaliação relacionado a Demandas emocionais e Dissonância da regra da emoção, Medida de Inteligência Emocional e a Escala de Autoeficácia Geral Percebida. Os resultados, obtidos por meio de Modelagem de Equações Estruturais, revelaram que a autoeficácia e a inteligência emocional desempenham um papel mediador entre o Trabalho emocional e a Síndrome de Burnout.