bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemotherapy of Prostatic Adenocarcinoma : State of the Art 2019
Authors: Essadi Ismail , Lalya Issam , Kaakoua Mohamed , El Omrani Abdelhamid , Khouchani Mouna , Belbaraka Rhizlane
Published: November 2019

Prostate cancer is a heterogeneous disease, with different clinical-biological and evolutionary aspects. Most often it is a disease with indolent evolution. Chemotherapy has long been a therapy of last resort in the treatment of prostate cancer. Deploying chemotherapy in this context certainly implied the failure of all possibilities of hormonal manipulation. Thus, antineoplastic chemotherapy was first proposed in metastatic situations, with resistance to castration. Many molecules have confirmed the effectiveness of chemotherapy in this indication. Several phase III trials have placed chemotherapy as a serious option in less advanced situations, with very encouraging results in terms of survival and quality of life. Chemotherapy is currently considered as a therapeutic weapon that should be included in the management strategy, after discussion in a multidisciplinary consultation meeting. Through this review, we will try to establish the state of the art of the use of antineoplastic chemotherapy in prostatic adenocarcinoma in 2018, in metastatic (de novo or in a phase of resistance to castration), localized, or locally advanced situations.
Asymmetric cipher based on MPF and its security parameters evaluation
Authors: Mihalkovič Aleksėjus , Sakalauskas Eligijus
Published: November 2019

The new asymmetric cipher algorithm based on matrix power function and matrix conjugation is presented. This algorithm is some alternative between known algorithms based on conjugacy problem, see e.g. Ko–Lee et al. and Anshel–Anshel–Goldfeld algorithm based on commutator concept. The security parameters are defined and their values are determined.
Generalized Green’s functions for second-order discrete boundary-value problems with nonlocal boundary conditions
Authors: Paukštaitė Gailė , Štikonas Artūras
Published: November 2019

In this paper, generalized Green’s functions for second-order discrete boundaryvalueproblems with nonlocal boundary conditions are investigated, where the necessaryand sufficient existence condition of discrete Green’s function is not satisfied and nonlocalboundary conditions are described by linear functionals.
On autoregressive moving-average models as a tool of virtual stock-exchange: experimental investigation
Authors: Mockus Jonas , Katina Joana , Katin Igor
Published: November 2019

The objective of this work is to investigate experimentally the well-known autoregressive models as simplest algorithms simulating prediction processes of the stockholders using the historical stock rates only. The “virtual” stock exchange which applies these algorithms can help in testing various assumptions of investor behavior. To represent users that prefer linear utility functions, the autoregressive moving-average model (ARMA-ABS(p, q)), minimizing the absolute values of prediction errors is regarded, in addition to the traditional ARMA(p, q) model which minimize the least square errors. The results of two hundred actual financial time series and a hundred of virtual ones are discussed in short.
The investigation of physiological data using the theory of complex systems
Authors: Bikulčienė Liepa , Poderienė Kristina , Butkevičiūtė Eglė , Landauskas Mantas
Published: November 2019

This paper presents a complex dynamic system assessment method based on Hankel matrix rank and inter-relationships between elements of the system evalution method. The possibilities of methods application for various physiological data measure and evaluation are introduced. The international project CareWare for portable sensors and systems development is briefly presented.
Nonpowder Firearm Injuries to Children Treated in Emergency Departments
Authors: Jones Margaret , Kistamgari Sandhya , Smith Gary A.
Published: November 2019

OBJECTIVES:

To investigate nonpowder firearm injuries treated in US emergency departments among children <18 years old.

METHODS:

National Electronic Injury Surveillance System data from 1990 through 2016 were analyzed.

RESULTS:

An estimated 364 133 (95% confidence interval 314 540–413 727) children <18 years old were treated in US emergency departments for injuries related to nonpowder firearms from 1990 to 2016, averaging 13 486 children annually. From 1990 to 2016, the number and rate of nonpowder firearm injuries decreased by 47.8% (P < .001) and 54.5% (P < .001), respectively. Most injuries occurred among 6- to 12-year-olds (47.4%) and 13- to 17-year-olds (47.0%). Boys accounted for 87.1% of injured children, the most common diagnosis was foreign body (46.3%), and 7.1% of children were admitted. BB guns accounted for 80.8% of injuries, followed by pellet guns (15.5%), paintball guns (3.0%), and airsoft guns (0.6%). The rate of eye injuries increased by 30.3% during the study period. Eye injuries accounted for 14.8% of all injuries and the most common diagnoses were corneal abrasion (35.1%), hyphema (12.5%), globe rupture (10.4%), and foreign body (8.6%).

CONCLUSIONS:

Although the number and rate of nonpowder firearm injuries declined during the study period, nonpowder firearms remain a frequent and important source of preventable and often serious injury to children. The severity and increasing rate of eye injuries related to nonpowder firearms is especially concerning. Increased prevention efforts are needed in the form of stricter and more consistent safety legislation at the state level, as well as child and parental education regarding proper supervision, firearm handling, and use of protective eyewear.
Dealing With the Caretaker Whose Judgment Is Impaired by Alcohol or Drugs: Legal and Ethical Considerations
Authors: Bondi Steven A. , Scibilia James ,   COMMITTEE ON MEDICAL LIABILITY AND RISK MANAGEMENT, Fanaroff Jon Mark , Altman Robin L. , Narang Sandeep K. , Oken Richard L. , Rusher John W. , Santucci Karen A. , Scott Susan M. , Sigman Laura J.
Published: November 2019

An estimated 8.7 million children live in a household with a substance-using parent or guardian. Substance-using caretakers may have impaired judgment that can negatively affect their child’s well-being, including his or her ability to receive appropriate medical care. Although the physician-patient relationship exists between the pediatrician and the child, obligations related to safety and confidentiality should be considered as well. In managing encounters with impaired caretakers who may become disruptive or dangerous, pediatricians should be aware of their responsibilities before acting. In addition to fulfilling the duty involved with an established physician-patient relationship, the pediatrician should take reasonable care to safeguard patient confidentiality; protect the safety of their patient, other patients in the facility, visitors, and employees; and comply with reporting mandates. This clinical report identifies and discusses the legal and ethical concepts related to these circumstances. The report offers implementation suggestions when establishing anticipatory procedures and training programs for staff in such situations to maximize the patient’s well-being and safety and minimize the liability of the pediatrician.
Nijmegen Questionnaire: A valid measure for hyperventilation syndrome
Authors: Li Ogilvie Vickie , Kayes Nicola M. , Kersten Paula
Published: November 2019

Hyperventilation syndrome is often undiagnosed due to its multi-systemic and apparently unrelated symptoms. The Nijmegen Questionnaire is used by clinicians to assess susceptible individuals, based on self-reporting symptoms attributed to hyperventilation syndrome. However, evidence of the psychometric properties of this questionnaire is lacking. This study investigated two types of validity using interviews and Rasch analysis. Data showed that the Nijmegen Questionnaire met criteria for content validity but not for structural validity. Content validity was supported by a high matching percentage between the symptoms identified within interview data and the current items on the Nijmegen Questionnaire (94%). Reported symptoms from study participants were conceptually congruent with most of the questionnaire items, with minor language inconsistencies between patients and clinicians. Rasch analysis indicated a poor fit of the Nijmegen Questionnaire to the Rasch model, demonstrating poor structural validity. This study also developed a revised 15 item version of the Nijmegen Questionnaire, which met criteria for structural validity. Subsequently, a conversion table was created for transforming raw total scores of the questionnaire in the clinical and research settings. Physiotherapists should use the revised 15-item Nijmegen Questionnaire for clinical and research purposes since it provides more accurate representation of the severity of patients’ symptoms than the original scoring.
EL CONCEPTO DE EDUCACIÓN Y SU RELACIÓN CON EL CRECIMIENTO ECONÓMICO EN LA UE-28
Authors: Miró Albert-Pol
Published: November 2019

RESUMEN

Los primeros análisis teóricos sobre la correlación entre educación y crecimiento económico fueron sustentados por Theodore Schultz, Edward Deninson y Gary Becker, durante la década de los 60. El estudio de las interconexiones dadas entre dichas variables viene determinada por la Economía de la Educación, la cual analiza de manera detallada cuales son las principales actuaciones que llevan los Estados nacionales sobre el sector educativo y sus consecuencias en el crecimiento económico de una sociedad.
Kanban Eletrônico para otimização de processos internos e externos da cadeia de suprimentos: aplicação em uma empresa do setor automotivo
Authors: Gisele Beheregaray Argollo Meira Gisele , Cortimiglia Marcelo Nogueira , Leso Bernardo Henrique
Published: November 2019

A presente pesquisa descreve a concepção, implantação e avaliação crítica de uma solução de Kanban Eletrônico em uma indústria do setor automotivo. Este setor possui muita dificuldade em integrar processos de abastecimento entre clientes e fornecedores, principalmente em consequência do efeito chicote característico desta indústria. Tendo isto em vista, além de uma série de outras dificuldades enfrentadas internamente na empresa em estudo que comprometem a eficiência e confiabilidade do processo, propôs-se a substituição do sistema tradicional de abastecimento de materiais por cartões Kanban pelo Kanban Eletrônico. Os resultados foram apresentados utilizando um método que separa a intervenção na empresa da pesquisa acadêmica, de forma que os dados coletados durante o projeto na empresa foram registrados e serviram de input para que se estruturasse e apresentasse os resultados da pesquisa. Assim, além de estudar o estado atual e propor uma projeção para o futuro, houve descrição do processo de implantação e exploração das dificuldades associadas. Ademais, apresenta-se uma análise crítica sobre os ganhos que o sistema proporcionou e ainda pode proporcionar à empresa.
Avaliação do nível de maturidade do processo de desenvolvimento de produtos de indústria eletroeletrônica
Authors: Takeda Yokoyama Tamie , Ledoux Takeda Berger Satie , De Oliveira Marco Aurélio , Frazzon Enzo Morosini , Futami André Hideto
Published: November 2019

A conquista de um estratégico, dinâmico e flexível Processo de Desenvolvimento de Produtos (PDP), permite que as empresas ganhem destaque e aumentem suas vendas, podendo melhorar suas participações no mercado, trazendo-lhes vantagem competitiva. Neste contexto, é relevante entender as práticas, procedimentos e ferramentas que compõe e determinam o nível de maturidade do PDP, a fim de estruturá-lo para obter um desempenho superior ao dos concorrentes. Este artigo tem por objetivo avaliar o nível de maturidade do PDP de uma indústria fabricante de eletrodomésticos e produtos eletrônicos. À vista disto, desenvolveu-se um estudo no qual é aplicado o questionário de um modelo de maturidade que considera a avaliação de 5 níveis de maturidade. Em cada nível é preciso obter mediana 4 em todas as questões para ser considerado como nível alcançado. A análise dos dados revelou que atualmente o PDP da indústria encontra-se no nível de maturidade 1, de uma escala de 1 a 5. Um diagnóstico mais detalhado do PDP da indústria é fornecido e a partir dele foram identificadas práticas críticas que ao receberem maior atenção gerencial podem proporcionar um aumento da maturidade de seu PDP.
Perdas de Grãos no Transporte e Armazenagem: Uma Revisão Sistemática da Literatura com Análise Bibliométrica
Authors: Deliberador Lucas Rodrigues , De Mello Luciana Torres Correia , Batalha Mário Otávio
Published: November 2019

A perda de alimentos vem se tornando um assunto relevante na agroindústria e estudado na literatura. Entre as perdas, destacam-se aquelas ocorridas devido à falta de estruturas de transporte e armazenagem de grãos. Considerando que o brasil é um dos principais produtores de soja e milho do mundo, essas perdas acarretam prejuízos financeiros significantes e diminuem a competitividade do país. Assim, o artigo objetiva identificar e analisar o que a literatura atual vem tratando sobre o tema e traçar sugestões de tendências futuras. Para isso, utilizou-se a ferramenta de Revisão Sistemática da Literatura (RSL), identificando os trabalhos presentes nas bases de dados Scopus, Web of Science e Scielo no período entre 2007 e 2017. Os resultados obtidos apresentam que a temática vem crescendo em número de publicações e que ainda há possibilidades de novas pesquisas. Sugerem-se pesquisas com novos termos que abranjam tipos de perdas em geral, desenvolvendo um framework com as perdas mais comuns por grãos, de modo a auxiliar os gestores e profissionais nas tomadas de decisões desse mercado e a minimizar as perdas pós-colheita.
Fatores intervenientes no armazenamento de laminados
Authors: Júnior Antonio Sporny , Alves João Eduardo
Published: November 2019

O armazenamento busca garantir a qualidade e a redução de custos, guardando os materiais utilizados na fabricação de maneira adequada. O objetivo desse trabalho foi evidenciar as etapas que mais impactam negativamente no processo de armazenamento em empresas de laminação de madeira. A pesquisa é explicativa e descritiva, com caráter qualitativo, utilizando o procedimento caracterizado como estudo de caso. Os dados utilizados para análises foram coletados através de observações não participantes e de sete entrevistas com os colaboradores participantes do processo de armazenagem. Tudo isso foi proposto com a justificativa de que o processo de armazenamento é essencial para as organizações, uma vez que diminui as perdas quando bem executado, além de proporcionar melhores condições para o desenvolvimento das atividades. Após a análise e discussão dos dados coletados, pode-se verificar que dentre as etapas apresentadas pelo processo estudado, as que mais agem negativamente no processo como um todo são a identificação, estocagem e manuseio dos insumos; identificação e estocagem dos produtos semiacabados; e, por fim, a conferência e separação de pedidos dos produtos acabados.
Talazoparib in Patients with a Germline BRCA-Mutated Advanced Breast Cancer: Detailed Safety Analyses from the Phase III EMBRACA Trial
Authors: Hurvitz Sara A. , Gonçalves Anthony , Rugo Hope S. , Lee Kyung-Hun , Fehrenbacher Louis , Mina Lida A. , Diab Sami , Blum Joanne L. , Chakrabarti Jayeta , Elmeliegy Mohamed , DeAnnuntis Liza , Gauthier Eric , Czibere Akos , Tudor Iulia Cristina , Quek Ruben G.W. , Litton Jennifer K. , Ettl Johannes
Published: November 2019

Background

In the EMBRACA phase III study (NCT01945775), talazoparib was associated with a significantly prolonged progression-free survival (PFS) compared with physician's choice of chemotherapy (PCT) in germline BRCA1/2-mutated HER2-negative advanced breast cancer (ABC). Herein, the safety profile of talazoparib is explored in detail.

Materials and Methods

Overall, 412 patients received ≥1 dose of talazoparib (n = 286) or PCT (n = 126). Adverse events (AEs) were evaluated, including timing, duration, and potential overlap of selected AEs. The relationship between talazoparib plasma exposure and grade ≥3 anemia was analyzed. Time-varying Cox proportional hazard models assessed the impact of dose reductions on PFS. Patient-reported outcomes (PROs) in patients with common AEs and health resource utilization (HRU) were assessed in both treatment arms.

Results

The most common AEs with talazoparib were hematologic (195 [68.2%] patients) and typically occurred within the first 3–4 months of receiving talazoparib. Grade 3-4 anemia lasted approximately 7 days for both arms. Overlapping grade 3-4 hematologic AEs were infrequent with talazoparib. Higher talazoparib exposure was associated with grade ≥3 anemia. Permanent discontinuation of talazoparib due to hematologic AEs was low (<2%). A total of 150 (52.4%) patients receiving talazoparib had AEs associated with dose reduction. Hematologic toxicities were managed by supportive care medication (including transfusion) and dose modifications. Among patients with anemia or nausea and/or vomiting AEs, PROs favored talazoparib. After accounting for the treatment-emergent period, talazoparib was generally associated with a lower rate of hospitalization and supportive care medication use compared with chemotherapy.

Conclusion

Talazoparib was associated with superior efficacy, favorable PROs, and lower HRU rate versus chemotherapy in gBRCA-mutated ABC. Toxicities were manageable with talazoparib dose modification and supportive care.
Harte Echtzeit für weiche Materialien
Authors: Hinze Christoph , Wnuk Markus , Lechler Armin , Verl Alexander
Published: November 2019

Die Automatisierung der Handhabung weicher Materialien mit Industrierobotern ist eine Herausforderung aufgrund der Komplexität des Materialverhaltens. Dieser Beitrag zeigt Probleme auf, die sich bei der Handhabung Linear Deformierbarer Objekte, wie Kabeln und Schläuchen, ergeben und stellt einen simulationszentrierten Ansatz zur Lösung vor, für den nicht nur der Roboter, sondern auch die zu handhabenden Objekte in der virtuellen Welt abgebildet werden. Der Ansatz basiert auf einer modularenArchitektur, die rechenaufwendige Simulationen mit der Echtzeitumgebung der Robotersteuerung verbindet.
Identifying Profiles of Democracies: A Cluster Analysis Based on the Democracy Matrix Dataset from 1900 to 2017
Authors: Schlenkrich Oliver
Published: November 2019

This study examines types of democracies that result from trade-offs within the democratic quality. Recently, the existence and relevance of trade-offs has been widely discussed. The idea is that the functions associated with the quality of democracy cannot all be maximized simultaneously. Thus, trade-offs are expressed in distinct profiles of democracy. Different profiles of democracy favour certain democracy dimensions over others due to their institutional design. Conceptually, we differentiate between four different democracy profiles: a libertarian-majoritarian (high political freedom, lower political equality, and lower political and legal control values), an egalitarian-majoritarian (high equality combined with lower freedom and control values), as well as two control-focused democracy profiles (high control values either with high degrees of freedom or high degrees of equality). We apply a cluster analysis with a focus on cluster validation on the Democracy Matrix dataset—a customized version of the Varieties-of-Democracy dataset. To increase the robustness of the cluster results, this study uses several different cluster algorithms, multiple fit indices as well as data resampling techniques. Based on all democracies between 1900 and 2017, we find strong empirical evidence for these democracy profiles. Finally, we discuss the temporal development and spatial distribution of the democracy profiles globally across the three waves of democracy, as well as for individual countries.
Free Trade versus Democracy and Social Standards in the European Union: Trade-Offs or Trilemma?
Authors: Wiesner Claudia
Published: November 2019

This article aims at conceptualising, in analytical as well as normative-theoretical terms, the tensions between free trade, democratic and social standards, and national sovereignty that are named in Dani Rodrik´s “globalisation trilemma” for the case of the European Union (EU). It is argued that the trilemma concept is much more fitting to the EU than a simple trade-off concept. This model offers a conceptual path to both analysing existing tensions and thinking of resolving them: a) the EU has, indeed, been intervening into national democracies and national sovereignty as its legislation is superior to national legislation; b) EU legislation and judgements of the Court of Justice of the EU have been reducing national social standards; c) executives and numerous new institutions and agencies with indirect legitimation have taken over competencies that formerly lay in the domain of national directly legitimated legislatives; and d) these negative effects relate to the EU’s giving preference to the liberalisation of free trade of capital, goods and services over democracy, social standards, and national sovereignty. Against the framework of the globalisation trilemma, analysis is combined with normative-theoretical judgements on the quality democracy of the setting that has been found and a conceptual discussion. The article concludes by discussing the perspectives of the setting examined and the possible paths to solutions, arguing that in order to keep a high level of economic integration, democracy, and social standards in the EU, national sovereignty needs to give way.
Characterization of Tuna Jerky with the Addition of Seaweed (Eucheuma cottonii) Flour
Authors: Lobo Reni , Santoso Joko , Ibrahim Bustami
Published: November 2019

Fish jerky has hard texture which could make the appearance became less attractive to consumers. The aim of this study was to characterize tuna jerky with the addition of seaweed flour E. cottonii in order to increase acceptability by consumers. Result shown that seaweed flour characterization was consisted dietary fiber 73.95±0.45%, viscosity 107.02±0.51 cPs, gel strength 435.03±4.99 g/cm2, carageenan 54.56±0.18%, heavy metal Hg was <0.002 ppm, Pb was <0.004 ppm and Cd was 0.063±0.001 ppm, water content 12.63±0.08% and yield 6.07±0.08%. Based on research result, the additional of 2.5% E. cottonii concentration flour resulting high quality jerky with appearance value was 7.60, flavour was 7.67, texture was 5.7 and taste was 7.63 from 1-9 scales. Result from paired comparison test against commercial jerky (beef) resulting positive value, that means the quality of tuna jerky had better quality compared to commercial jerky and well accepted by panelist. Proximate analysis of tuna jerky shown that protein content 30.24±0.1%, water 11.32±0.02%, lipid 3.03±0.00% and ash 5.69±0.06%. Texture analysis results shown hardness 827.50±15.67, adhesiveness 0.09±0.02 and fracture 10.95±2.24.
Utilization of Carp (Cyprinus carpio) as Surimi For Sausage Manufacturing
Authors: Eveline Eveline , Santoso Joko , Huangdinata Magnarai
Published: November 2019

Carp (Cyprinus carpio) is a freshwater fish with high economic value and good farming potential. Carp-based product diversification could be done by using it as food ingredients such as surimi in sausage manufacture. This research was aimed to evaluate sausage produced from carp surimi by varying washing frequency and tapioca filler concentration. Five washing frequencies (1; 2; 3; and 4 times) and three tapioca filler concentrations (2; 3; and 4%) were compared. The study showed 1 time washing frequency gave better surimi physical characteristics (57.40% yield; 73.76% water holding capacity; 26.64% expressible moisture content, 821.92 g.cm gel strength; 54.45% whiteness) and chemical characteristic (78.00% moisture content and 6.34% salt soluble protein) compared to other washing frequencies. Based on the organoleptic test, 2% tapioca was the selected filler concentration. Selected surimi sausage had better physical, chemical and sensori characteristics than commercial sausage. The physical characteristics of the selected sausage were 70.46% water holding capacity; 24.58% expressible moisture content; 78.64% whiteness; 4346.70 g.cm gel strength; 101.23 g hardness; 0.98 g springiness; and 43.96 g chewiness. While the chemical characteristics of that sausage were 75% water; 1.35% ash; 11.51% protein; 4.46% fat; and 7.63% carbohydrate. The sensory scores of the sausage evaluated were color 0.44, aroma 0.60; taste 1.16; and springiness 1.86.
Characteristic of Seaweed Porridge Eucheuma cottonii and Turbinaria conoides as Raw Peel off Mask
Authors: Nurjanah Nurjanah , Fauziyah Siti , Abdullah Asadatun
Published: November 2019

Peel off seaweed masks have active ingredients and antioxidants are needed. The use of seaweed porridge as raw material for peel off masks is an alternative because it zero waste and low production costs. The purpose of this study was to determine the characteristic and the best ratio porridge seaweed of Eucheuma cottonii and Turbinaria conoides as a raw material for peel masks, and also peel masks from the ratio of the best seaweed porridge. The porridge seaweed E. cottonii and T. conoides were characterized including moisture, pH, phytochemicals and antioxidants. The ratio of the best seaweed pulp is formulated for peel off skin masks that characterized by pH, viscosity, dry time, dispersion, antioxidant, and sensory. The results showed that the best porridge ratio of E. cottonii and T. conoides was obtained at a ratio of 1:1 with a pH value of 6.3; IC50 value is 137.36 ppm. Porridge E. cottonii and T. conoides contain a bioactive components. Peeled masks with a 1:1 ratio of seaweed porridge formula have the characteristics of drying time for 25.50 minutes, dispersing power of 5.5 cm, viscosity of 7,200 cP, pH value 6.81, and containing antioxidants 902.58 ppm. Sensory peel off masks seaweed formulas against appearance, color, odor, and texture are no different from peel masks without seaweed formulas and commercial masks.
Orta Ergenlik Döneminde Problemli İnternet Kullanımının Demografik Değişkenler Açısından İncelenmesi
Authors: Çelikkaleli Öner , Ata Rıdvan , Avcı Raşit
Published: November 2019

Bu araştırmanın birinci
amacı, ergenlerin problemli internet kullanımını cinsiyet, akıllı telefonunun
olup olmama ve anne-baba eğitim düzeyine göre incelemektir. İkinci olarak,
problemli internet kullanım düzeylerini ve interneti kullanım amaçlarını ortaya
koymaktır. Bu amaçla Türkiye’nin farklı bölgelerinden orta ergenlik döneminde
olan 1886 öğrenciden veri toplanmıştır. Verilerin analizinde tek yönlü varyans
analizi ve çok faktörlü varyans analizi kullanılmıştır. Elde edilen ilk
bulgulara göre, erkek ergenlerin İşlevsellikte Bozulma, Sosyalizasyon ve Toplam
ölçek puanları kadın ergenlerden daha yüksektir. İkinci olarak, akıllı telefonu
olan ergenlerin tüm alt ölçek ve toplam puanları olmayanlara göre daha
yüksektir. Son olarak, ergenlerin 304’ünün (%16,1) problemli internet
kullanıcısı olduğu ve ergenlerin interneti en çok sosyal ağlara girmek için
kullandıkları söylenebilir.
Mathematics Teachers’ Views on Mathematical Thinking
Authors: ÜNVEREN BİLGİÇ Emine Nur , AZAK Ayşe Zeynep
Published: November 2019

The aim of this research is to examine the opinions of mathematics teachers about mathematical thinking. The study examined teachers’ knowledge level and views regarding mathematical thinking within the scope of a class titled “Development of Mathematical Thinking Skills in Children” in educational sciences institute of a university. The study was conducted in a pattern of descriptive case study following a qualitative paradigm. Descriptive case studies are definitive. Participants considered mathematical thinking as a process in which they related real life and mathematics in preeducation. In posteducation process, however, the participants were able to define mathematical thinking with several different viewpoints and examples and explain the process with examples.
Matematik ve Fen Bilimleri Öğretiminde Akıllı Tahta Kullanımının Öğrencilerin Akademik Başarılarına Etkisi Üzerine Bir Meta-Analiz Çalışması
Authors: GÜNDÜZ Samet , KUTLUCA Tamer
Published: November 2019

Bu araştırmada matematik ve fen bilimleri öğretiminde akıllı tahta kullanımının öğrencilerin akademik başarıları üzerindeki etkisini incelemek amacıyla meta-analiz çalışması yapılmıştır. Araştırmada 2008-2018 yılları arasında gerçekleştirilmiş 35 çalışma incelenmiş ve dâhil edilme kriterlerine uygun olan 25 çalışma meta-analiz yöntemiyle birleştirilmiştir. Çalışmalar birleştirilirken yapının heterojen olmasından dolayı rastgele etkiler modeli kullanılmıştır. Araştırma sonucunda, matematik ve fen bilimleri öğretiminde akıllı tahta kullanımının öğrencilerin akademik başarısına etki büyüklüğü 0.807 olarak bulunmuştur. Bu değer yapılan sınıflandırmaya göre geniş düzeyde bir etki büyüklüğüdür. Buna göre akıllı tahta kullanımının öğrencilerin akademik başarısını arttırmada olumlu yönde ve geniş düzeyde bir etkiye sahip olduğu sonucuna ulaşılmıştır. Akademik başarıya olan etki büyüklüğü örneklem grubuna göre farklılaşırken, yayım türü, yayım yılı, örneklem büyüklüğü ve disiplin alanlarına göre farklılaşmamaktadır.
Matematik Öğretmen Adaylarının, Matematik Etkinliklerindeki Sanata Yönelik Metaforik Algıları
Authors: KÜKEY Ebru , KÜKEY Hilal , TUTAK Tayfun
Published: November 2019

Araştırmanın amacı, matematik öğretmen adaylarının matematik etkinliklerindeki sanat algılarını, metaforlar aracılığıyla belirlemektir. Çalışmanın yöntemi, nitel araştırma desenlerinden olgu bilim olarak tasarlanmıştır. Araştırmanın çalışma grubunu, matematik öğretmenliği programında öğrenim gören 92 öğretmen adayı oluşturmaktadır. Veriler, öğretmen adaylarının “Matematik etkinlikleri … sanatıdır, çünkü …” cümlesini tamamlamalarıyla elde edilmiştir. Öğretmen adaylarının vermiş oldukları cevapların çözümlenmesinde içerik analizi kullanılmış ve verilerin kodlamaları yapılarak uygun temalar belirlenmiştir. Değerlendirmeler sonucunda matematik öğretmenlerinin sanata yönelik metaforik algıları zihin, meslek, matematiksel, hayat ve aktivite olmak üzere 5 tema altında belirlenmiştir. Elde edilen sonuçlar doğrultusunda, matematik eğitiminde kavramlar arasındaki ilişkiye ve düzene dayalı olarak yapılmasının önemli olduğu sonucuna varılmıştır.
The Scale of Happiness Strategies for Childrens Used by Preschool Teachers
Authors: SAPSAĞLAM Özkan , BAKKALOĞLU Ayça Bahar , ERYILMAZ Ali
Published: November 2019

The aim of this study is to develop a scale of subjective well-being strategies used by preschool teachers for pre-school education childrens. This study covers the 2018-2019 academic years. The research was conducted with the participation of pre-school teachers in Istanbul. 230 pre-school teachers participated in the study. In this study, the stages of scale development were followed. Firstly interviews were made with teachers. During the interviews, an information gathering tool was developed, including demographic information. The following steps were followed in the study: Creation of item pool, creation of the scale trial form, implementation of scales, item analysis, explanatory factor analysis, reliability. According to the results of the study, a three-dimensional scale was reached. Dimensions of the scale; positive relationships with childrens, to satisfy the wishes of the childrens and play the game with the childrens are called. In this process, studies can be carried out with this scale.
Akademik Hayatta Sabır Üzerine Nitel Bir Çalışma
Authors: KIRAL Bilgen
Published: November 2019

Araştırma doktora
öğrencilerinin akademide sabır kavramına ilişkin görüşlerini tespit etmek
amacıyla yapılmıştır. Çalışma, 2018-2019 akademik yılında Aydın Adnan Menderes
Üniversitesi Eğitim Fakültesi’nde doktora öğrenimi gören 8 doktora öğrencisi
ile yürütülmüştür. Araştırmada nitel araştırma desenlerinden fenomenoloji
deseni kullanılmıştır. Araştırmada katılımcılar ölçüt örneklem, kolay
ulaşılabilir durum örneklemesi ve maksimum çeşitlilik örnekleme yöntemi ile
gönüllülük esasına göre seçilmişlerdir. Araştırmada veriler, araştırmacı
tarafından oluşturulan yarı yapılandırılmış görüşme formu ile toplanmış,
veriler içerik analizi yöntem ile analiz edilmiştir. Araştırmada geçerlik,
güvenirlik, etik unsurlara dikkat edilmiştir. Araştırmada sabır kavramı çözüm yolu
bulma ve olayı kapatma ile eğitim kategorileri içerisinde ele alınmıştır.
Akademide dersler/akademik çalışmalar, arkadaşlar, hocalar ve fiziki ortama
sabır gösterildiği; akademide sabır göstermenin doktora öğrencileri üzerinde
psikolojik, bedensel, ailesel ve sosyal hayat/arkadaşlar ilişkileri üzerinde
etkileri olduğu sonucuna varılmıştır.
İlköğretim Matematik Öğretmen Adayları Bağlam Temelli Öğrenme Hakkında Ne Düşünüyor? Nitel Bir Araştırma
Authors: OBAY Mustafa , ÇELİK Halil Coşkun
Published: November 2019

Bu çalışmanın amacı
ilköğretim matematik öğretmen adaylarının bağlam temelli öğrenme ve bağlamsal
problemler hakkındaki görüşlerinin incelenmesidir. Çalışma nitel araştırma
yöntemlerinden olgubilim (fenomenoloji) modelindedir. Araştırma, bir devlet
üniversitesinin eğitim fakültesi, matematik ve fen bilimleri eğitimi bölümünde
okuyan 12 öğretmen adayı ile yürütülmüştür. Proje kapsamında öğretmen
adaylarının bağlam temelli öğrenme etkinlikleri sonucu elde ettikleri
deneyimler hakkında görüşlerinin alınabilmesi için yarı yapılandırılmış görüşme
formu kullanılmıştır. Görüşme formundan elde edilen verilerin analizinde içerik
analizi kullanılmıştır. Araştırmanın sonuçları incelendiğinde; öğretmen
adaylarının bağlam temelli öğrenmeye yönelik gerek bilişsel ve gerekse duyuşsal
pozitif bir yaklaşım sergiledikleri görülmüştür. Bununla birlikte öğretmen
adaylarının öğretmenlik deneyimlerinin çok yeterli olmamasından kaynaklı bağlam
temelli öğrenme için eksikliklerin belirlenmesinde yetersiz kaldıkları
görülmüştür.
The Use of Dynamic Geometry Software from a Pedagogical Perspective: Current Status and Future Prospects
Authors: İBİLİ Emin
Published: November 2019

This research firstly aims to reveal the
pedagogical potentials and limitations of dynamic geometry software (DGS). For
this purpose, research on Cabri (2D/3D/Plus), the Geometer’s Sketchpad,
GoogleSketchUp, GeoGebra and Logo software was reviewed and compiled. As a
result of the research, it appears that DGS offers an effective pedagogical
environment because of its ability to interact with digital materials and allow
for geometric objects to be seen from all sides. However, we found that
teachers have some problems in combining DGS with class pedagogy. In this
study, the effects of gender, age, education level, skill in using technology
and the influence of professional experience were also examined in relation to
primary school mathematics teachers’ preferences in using DGS. As a result of
this research, it was found that GeoGebra and Cabri were the most-used DGS
packages by primary school mathematics teachers, while other geometry software
was less preferred by teachers.
Editorial e Ã­ndice - Revista T&D
Authors: De IngenierÃ­a Facultad
Published: November 2019

La Revista TecnologÃ­a y Desarrollo, editada por la Facultad de IngenierÃ­a de la Universidad CÃ©sar Vallejo de Trujillo.

El objetivo de nuestra revista T&D es impulsar la difusiÃ³n del conocimiento cientÃ­ï€co y tecnolÃ³gico  generado en la Universidad, poniÃ©ndola a disposiciÃ³n de la sociedad, comunidad cientÃ­ï€ca y empresas inmersas en la tecnologÃ­a y desarrollo de nuestra regiÃ³n.
Mejoramiento del banco de pruebas para obtener curvas caracterÃ­sticas de operaciÃ³n de bombas centrifugas fabricadas en la empresa industrial Moreno, El Milagro â€“ Huanchaco â€“ La Libertad
Authors: Amaya Benites Marcos Antonio
Published: November 2019

La presente investigaciÃ³n se realizÃ³ con el objetivo de determinar las especiï€caciones tÃ©cnicas de los componentes para mejorar el equipo de ensayo de las bombas centrifugas fabricadas en la empresa Industrial Moreno S.A Trujillo y obtener las curvas caracterÃ­sticas de operaciÃ³n para diferentes velocidades de rotaciÃ³n. El DiseÃ±o de investigaciÃ³n experimental, del tipo experimental puro, debido a que se hicieron pruebas directamente en el equipo mejorado de ensayo construido en la empresa Industrial Moreno S.A. PoblaciÃ³n y muestra: Equipo de pruebas de Bombas centrifugas de agua Fabricada en la empresa Industrial Moreno S.A. Actualmente la empresa Industrial Moreno Realiza su propio proceso de fundiciÃ³n, utilizando el mÃ¡s comÃºn y factible proceso de fabricaciÃ³n como es la fundiciÃ³n en arena, siendo Ã©sta un material refractario muy abundante en la naturaleza y que, mezclada con arcilla, adquiere cohesiÃ³n y moldeabilidad sin perder la permeabilidad que posibilita evacuar los gases del molde al tiempo que se vierte el metal fundido, garantizando un adecuado molde y por ende de la pieza obtenida. Para muchos ingenieros la aplicaciÃ³n de bombas es un tema nebuloso, rodeado por una abundancia de informaciÃ³n miscelÃ¡nea que es difÃ­cil de relacionar con un problema dado. Los resultados obtenidos de las pruebas realizadas en el banco de pruebas usando los nuevos componentes, son coherentes con las pruebas realizadas en el antiguo banco de ensayos, ademÃ¡s de veriï€car su adecuado funcionamiento dentro de los valores permisibles con los que fueron seleccionados, llegando a alcanzar valores mÃ¡ximos del 90% del rendimiento. Se graï€caron las cuatro curvas caracterÃ­sticas de la bomba de agua fabricadas en Industrial Moreno S.A Trujillo, con lo cual se completÃ³ la ï€cha tÃ©cnica de estas bombas. El nuevo equipo de ensayo fue cotizado y arrojo un costo total de S/.12185 Soles, lo cual es accesible por la empresa y cubierto dentro del costo de fabricaciÃ³n de las bombas de la empresa. Conclusiones: Se determinÃ³ la curva del comportamiento de la altura de succiÃ³n positiva neta en funciÃ³n del caudal de bombeo para diferentes velocidades de rotaciÃ³n; Se calculÃ³ las pÃ©rdidas generadas en la lÃ­nea de succiÃ³n, por la vÃ¡lvula de estrangulamiento, principalmente que disminuyeron al NPSH disponible de la instalaciÃ³n hasta que se presentase cavitaciÃ³n; Se graï€caron las cuatro curvas caracterÃ­sticas de la bomba de agua fabricadas en Industrial Moreno S.A Trujillo, con lo cual se completÃ³ la ï€cha tÃ©cnica de estas bombas; El nuevo equipo de ensayo tiene un costo total de S/.12185 Soles.

Palabras clave: Bomba de agua, Bomba centrifuga, Banco de ensayo.
Sistema de seguimiento de expedientes vÃ­a web para mejorar gestiÃ³n de los casos penales en el Estudio JurÃ­dico ABC - Consultores del distrito de Trujillo.
Authors: PÃ©rez Aguilar Jorge Omar
Published: November 2019

En el desarrollo de esta investigaciÃ³n se propuso un sistema de seguimiento vÃ­a web para mejorar la gestiÃ³n de los casos penales en el estudio jurÃ­dico ABC-Consultores del distrito de Trujillo, el objetivo general trazado para el tiempo de duraciÃ³n de esta investigaciÃ³n, es el de â€œMejorar la gestiÃ³n de seguimiento de los expedientes vÃ­a web de los casos penales en el estudio jurÃ­dico ABC-consultores, del distrito de Trujilloâ€. Mediante la recolecciÃ³n de datos e informaciÃ³n en el estudio jurÃ­dico y con el apoyo del asesor asignado, se pudo determinar la poblaciÃ³n para la investigaciÃ³n; en este caso estÃ¡ constituida por doscientos(200) expedientes que maneja el estudio regularmente cada aÃ±o; la muestra requerida para la investigaciÃ³n sugiere el uso de una fÃ³rmula matemÃ¡tica. De los expedientes anuales que maneja el estudio jurÃ­dico solo se ha requerido 132 para la investigaciÃ³n. Para poder obtener la informaciÃ³n necesaria se tuvo que recurrir a mÃ©todos e instrumentos de recolecciÃ³n de datos, el cual consistÃ­a en encuestas basadas en la gestiÃ³n de los expedientes manejados por los abogados que llevan los casos penales en el estudio jurÃ­dico y asÃ­ poder realizar el anÃ¡lisis de fiabilidad del instrumento de recolecciÃ³n de datos. Posteriormente para el proceso de anÃ¡lisis de datos, se utilizÃ³ pruebas de normalidad, utilizando para ello el mÃ©todo de KolmogorovSiminov.Se utilizaron pruebas funcionales en la verificaciÃ³n de la efectividad del sistema, para determinar con el cumplimiento de las expectativas. Durante la contrastaciÃ³n de hipÃ³tesis se pudo verificar la veracidad de los objetivos especÃ­ficos, asÃ­ mismo se verificÃ³ si el objetivo general que se propuso para esta investigaciÃ³n era la correcta.Prueba de este cumplimiento es que previo a la implementaciÃ³n del sistema el tiempo promedio en el que los abogados podÃ­an acceder a los expedientes que habÃ­an sido guardados en el almacÃ©n de archivos era de 11.93 min. posteriormente con la implementaciÃ³n del sistema ese tiempo se vio mejorado reduciendo a 6 min. Finalizando la investigaciÃ³n, se obtuvo como conclusiones: La reducciÃ³n del tiempo promedio en la gestiÃ³n de los casos penales y en la consulta de los expedientes, y se puso de maniï€esto el incrementÃ³ en la satisfacciÃ³n de los trabajadores del estudio jurÃ­dico.

Palabras clave: Expedientes penales, estudio jurÃ­dico, sistema de seguimiento.
P53-dependent suppression of the human calcyclin gene (S100A6): the role of Sp1 and of NFkappaB.
Authors: Króliczak Weronika , Pietrzak Maciej , Puzianowska-Kuznicka Monika
Published: November 2019

Calcyclin (S100A6) is believed to participate in cell cycle control. It was, however, unclear if its expression depends on p53, a key regulator of apoptosis and cell cycle. We therefore performed transcription regulation assays in HeLa cells and found that wild type p53 suppressed the S100A6 promoter up to 12-fold in a dose-dependent manner. In contrast, the well-characterized V143A, R175H, R249S, and L344A p53 mutants cloned from human cancers suppressed this promoter with a 6 to 9-fold lower efficiency. All the sites mediating the p53-dependent suppression were contained in the -167 to +134 fragment of the S100A6 promoter. Separate overexpression of either Sp1 or of NFkappaB only partially counteracted the p53 inhibitory effect on the S100A6 promoter, while simultaneous overexpression of both these transactivators resulted in a complete abolishment of the p53 inhibitory effect on this promoter. Sp1 and NFkappaB binding to the probes resembling their putative binding sites present in the S100A6 promoter was decreased in the presence of wild type p53. We propose that the suppression of S100A6 is yet another mechanism by which p53 inhibits proliferation. Insufficient suppression of this gene by p53 mutants could well be responsible for calcyclin overexpression and cell cycle deregulation observed in cancer tissues.
Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione.
Authors: Cheluvappa Rajkumar , Shimmon Ronald , Dawson Michael , Hilmer Sarah N , Le Couteur David G
Published: November 2019

Pseudomonas aeruginosa is the most common cause of chronic and recurrent lung infections in patients with cystic fibrosis (CF) whose sputa contain copious quantities of P. aeruginosa toxin, pyocyanin. Pyocyanin triggers tissue damage mainly by its redox cycling and induction of reactive oxygen species (ROS). The reactions between reduced glutathione (GSH) and pyocyanin were observed using absorption spectra from spectrophotometry and the reaction products analysed by nuclear magnetic resonance imaging. Pyocyanin reacted with GSH non-enzymatically at 37 degrees C resulting in the production of red-brown products, spectophotometrically visible as a 480 nm maximum absorption peak after 24 h of incubation. The reaction was concentration-dependent on reduced glutathione but not on pyocyanin. Minimizing the accessibility of oxygen to the reaction decreased its rate. The anti-oxidant enzyme catalase circumvented the reaction. Proton-NMR analysis demonstrated the persistence of the original aromatic ring and the methyl-group of pyocyanin in the red-brown products. Anti-oxidant agents having thiol groups produced similar spectophotometrically visible peaks. The presence of a previously unidentified non-enzymatic GSH-dependent metabolic pathway for pyocyanin has thus been identified. The reaction between pyocyanin and GSH is concentration-, time-, and O(2)-dependent. The formation of H(2)O(2) as an intermediate and the thiol group in GSH seem to be important in this reaction.
Regulation of RNA polymerase III transcription by Maf1 protein.
Authors: Cieśla Małgorzata , Boguta Magdalena
Published: November 2019

Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evolutionarily conserved, a Maf1 ortholog also serves to restrain transcription in mouse and human cells. Understanding the mechanism of the regulation has been made possible by recent studies showing that Maf1 is a nuclear/cytoplasmic protein whose subcellular distribution and hence negative regulation of Pol III transcription is mediated by the nutrient-sensing signaling pathways, TOR and RAS. Under stress conditions and during growth in a nonfermentable carbon source Maf1 is dephosphorylated and imported to the nucleus. In its non-phosphorylated form, Maf1 interacts with the polymerase III transcription machinery. Phosphorylation serves to locate Maf1 to the cytoplasm under favorable growth conditions, thereby preventing it from non-negatively regulating polymerase III when high levels of tRNA transcription are required. Relocation of Maf1 to the cytoplasm is dependent on Msn5, a carrier responsible for export of several other phosphoproteins out of the nucleus. The absence of Maf1-mediated control of tRNA synthesis impairs yeast viability in nonfermentable carbon sources. Moreover, in cells grown in a nonfermentable carbon source, Maf1 regulates the levels of different tRNAs to various extents. This differential regulation may contribute to the physiological role of Maf1.
Limited proteolysis of E. coli ATP-dependent protease Lon - a unified view of the subunit architecture and characterization of isolated enzyme fragments.
Authors: Melnikov Edward E , Andrianova Anna G , Morozkin Andrey D , Stepnov Anton A , Makhovskaya Oksana V , Botos Istvan , Gustchina Alla , Wlodawer Alexander , Rotanova Tatyana V
Published: November 2019

We carried out chymotryptic digestion of multimeric ATP-dependent Lon protease from Escherichia coli. Four regions sensitive to proteolytic digestion were located in the enzyme and several fragments corresponding to the individual structural domains of the enzyme or their combinations were isolated. It was shown that (i) unlike the known AAA(+) proteins, the ATPase fragment (A) of Lon has no ATPase activity in spite of its ability to bind nucleotides, and it is monomeric in solution regardless of the presence of any effectors; (ii) the monomeric proteolytic domain (P) does not display proteolytic activity; (iii) in contrast to the inactive counterparts, the AP fragment is an oligomer and exhibits both the ATPase and proteolytic activities. However, unlike the full-length Lon, its AP fragment oligomerizes into a dimer or a tetramer only, exhibits the properties of a non-processive protease, and undergoes self-degradation upon ATP hydrolysis. These results reveal the crucial role played by the non-catalytic N fragment of Lon (including its coiled-coil region), as well as the contribution of individual domains to creation of the quaternary structure of the full-length enzyme, empowering its function as a processive protease.