bluuebunny/crossref_metadata_2025 huggingface dataset:
VAI TRÒ CỦA HÚT HUYẾT KHỐI TRONG CAN THIỆP NHỒI MÁU THẬN CẤP NHÂN MỘT TRƯỜNG HỢP LÂM SÀNG TẠI VIỆN TIM MẠCH VIỆT NAM
Authors: Mạnh Quân Nguyễn , Quang Tùng Ngô , Thị Ly Đào , Thị Thanh Bình Trương
Published: January 2022

Tổng quan: Nhồi máu thận cấp là bệnh lý hiếm gặp trên lâm sàng, thường bị bỏ sót hoặc chẩn đoán nhầm lẫn với các tình trạng bệnh lý khác do biểu hiện lâm sàng đa dạng và không đặc hiệu. Bệnh cần được chẩn đoán sớm và điều trị để tránh làm ảnh hưởng tới chức năng thận. Hiện nay, chưa có khuyến cáo rõ ràng về điều trị tối ưu cho nhồi máu thận cấp. Can thiệp hút huyết khối qua đường ống thông kèm điều trị nội khoa phối hợp có thể là một lựa chọn trong chiến lược điều trị bệnh nhân nhồi máu thận cấp. Phương pháp: Báo cáo ca lâm sang. Kết quả: Chúng tôi báo cáo ca lâm sàng hiếm gặp tại Viện Tim Mạch, Bệnh viện Bạch Mai. Bệnh nhân nam, 34 tuổi nhập viện vì đau vùng hông lưng trái với huyết khối cấp tính gây tắc nhánh cực trên động mạch thận trái, được chẩn đoán và điều trị kịp thời và cho kết quả điều trị tốt. Kết luận: Nhồi máu thận cấp là một bệnh không phổ biến và dễ bị bỏ sót. Việc chọn lựa phương pháp điều trị phụ thuộc vào từng trường hợp cụ thể.
Molecular docking of lutein as anti-photoaging agent in silico
Authors: Krisnayana I Gede Bayu , Febyani Putu Dewi , Sari Ida Ayu Yadnyaningtias Permata , Laksmiani Ni Putu Linda
Published: January 2022

The accumulation of UV exposure resulted in the loss of skin elasticity, and the appearance of wrinkles on the skin is commonly known as photoaging. Matrix metalloproteinase-1 (MMP-1) is an enzyme that degrades type I and III fibrillar collagen. This study aims to determine the mechanism of MMP-1 inhibition by lutein, a carotenoid compound with high antioxidant activity, using in silico molecular docking. This study was conducted by optimization of lutein structure using HyperChem 8, preparation of MMP-1 (PDB ID: 966C) using Chimera 1.10.1, validation of the method, and docking lutein against MMP-1 using Autodock 4.2. The results showed lutein had binding energy of -12.28 kcal/mol, lower than RS2 native ligand (-10.83 kcal/mol). The hydrogen bond formed between lutein and MMP-1 through HIS228 residue. To conclude, lutein may be developed as an anti-photoaging agent by inhibiting the MMP-1.
Azacitidine (Onureg)
Authors: Reimbursement Team
Published: January 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses azacitidine (Onureg), tablet 300 mg, oral.
Indication: Maintenance therapy in adult patients with acute myeloid leukemia who achieved complete remission or complete remission with incomplete blood count recovery following induction therapy with or without consolidation treatment, and who are not eligible for hematopoietic stem cell transplantation.
Pemanfaatkan Potensi Lokal Melalui Pembuatan Susu Jagung Guna Mencegah Stunting Pada Desa Gejugan
Authors: Setiyono Agus Edi , Ngatimun Ngatimun , Musriati Titik
Published: January 2022

Gejugan Village is one of the villages in Probolinggo district on the north coast. Gejugan Village is in the west bordering Klaseman Village and Karangpranti Village, Pajarakan District. Gejugan village has local potential that can be developed from their agricultural produce, namely corn. Corn is an alternative food source that contains many nutrients. But the people here still don't have the knowledge to be able to use it. The Socialization Activity for Making SUJU (Corn Milk) to Prevent Stunting and Utilizing Local Potential is expected to provide more knowledge to the Gejugan community in utilizing existing local potential, especially processing corn into corn milk. Besides having good nutrition, corn milk also has more value in the economy. If it is processed properly and properly, this product can be sold in the market. The socialization of making corn milk was attended by 25 residents of Gejugan Village. Material for making corn milk was given by providing materials and hands-on practice during the event. Participants in the socialization of making corn milk enthusiastically listened to and practiced directly making corn milk during the socialization process. From the results of the socialization, the practiced corn milk resulted in 6 bottles of corn milk measuring 360 ml. Participants listened well and the material presented was well received by all participants present.

Keywords: Local Potential, Corn Milk, Stunting
Upaya Pencegahan dan Pemberdayaan Ekonomi Masyarakat Terdampak Covid-19 di Kecamatan Kademangan Kota Probolinggo
Authors: Mubaroq Husni , Halima Nur
Published: January 2022

Virus covid-19 merupakan virus yang penyebarannya melalui droplet antarmanusia dan bersentuhan langsung dengan benda yang terpapar virus. Menaiknya kasus aktif covid-19 di Kota Probolinggo khususnya Kecamatan Kademangan dikarenakan masyarakatnya masih kurang informasi mengenai penyebaran dan pencegahan covid-19. Akibatnya banyak masyarakat yang terdampak secara ekonomi dikarenakan pandemi covid-19. Tujuan dari pengabdian masyarakat ini untuk mencegah penyebaran virus covid-19, menumbuhkan pola hidu sehat, serta memberdayakan ekonomi masyarakat yang terdampak covid-19.  Mitra pengabdian kami adalah pengelola terminal Bayuangga dan UMKM Bakpia Manalagi. Metode pengabdian pada pengabdian masyarakat berupa edukasi mengenai 3M, dan penyaluran bantuan tempat cuci tangan di Terminal Bayuangga, serta melakukan pemberdayaan ke UMKM Bakpia Manalagi dengan cara membantu perluasan pemasaran dengan metode digital marketing. Dengan pengabdian masyarakat yang sudah dilaksanakan, didapatkan hasil pemahaman mengenai pentingnya melakukan 3M apabila beraktifitas di luar rumah dan dengan melakukan perluasan pemasaran memakai digital marketing mampu menaikkan permintaan produk yang berimbas pada kebutuhan akan karyawan yang dapat memberdayakan masyarakat sekitar.Kata lunci : Covid-19, Pola Hidup Sehat, Digital Marketing, Pencegahan Covid-19, Pemberdayaan Masyarakat
Pemberdayaan Masyarakat yang Tanggap dan Waspada di Masa Pandemi Covid-19 di Kecamatan Mayangan
Authors: Trismawati Trismawati , Maulana Adam Febrian
Published: January 2022

Dalam masa pandemic Covid-19 tingginya angka penyebaran virus di daerah Probolinggo menyebabkan terganggunya stabilitas dalam segala aspek. Dengan latar belakang masalah tersebut kegiatan KKN (Kuliah Kerja Nyata) Universitas Panca Marga kelompok kecamatan Mayangan menyusun program kerja dengan fokus untuk menambah wawasan dan kesiagaan tentang bahaya dari penularan virus Covid-19 yang implementasikan melalui kegiatan penyuluhan 5M, pembagian masker dan hand sanitizer, penanaman TOGA (Tanaman Obat Keluarga), penyemprotan cairan desinfektan pada fasilitas umum dan pembuatan produk sari belimbing wuluh. Hasil dari kegiatan adalah meningkatnya wawasan dan kesiagaan masyarakat kecamatan Mayangan tentang bahaya penularan virus Covid-19 dan cara pencegahannya. Kesimpulan dari kegiatan pengabdian masyarakat yang dilaksanakan di kecamatan Mayangan ini adalah perlunya penyuluhan dan sosialisasi tentang penyebaran virus Covid-19 dalam lingkungan masyarakat apapun dikarenakan infeksi virus Covid-19 dapat menyerang siapa saja.
Pemberdayaan Pendidikan Literasi Anak Sekolah Dasar melalui Pojok Membaca di Desa Tamansuruh
Authors: Martha Jefry Aulia , Pramudya Galang Bintang , Apriliyani Dewi , Tulung Dewi Oktaviani , Dzikrulloh Mohammad Hilfi Azra
Published: January 2022

Pandemi covid-19 telah membuat dunia pendidikan berubah. Seluruh sekolah akhirnya menerapkan pembelajaran secara dari dengan model peserta didik belajar dari rumah. Akibatnya banyak sekali hal yang berubah mulai dari pola pikir hingga cara belajar. Permasalahan itu yang melatarbelakangi, tim KKN Pulang Kampung ini untuk membuat kegiatam pojok membaca. Membaca merupakan kegiatan yang penting dalam kehidupan sehari-hari, karena bukan sekedar untuk memperoleh informasi, tetapi dapat juga sebagai alat untuk memperluas pengetahuan dan gaya bahasa seseorang sehingga dengan adanya kegiatan ini peserta diharapkan dapat meningkatkan kemampuan literasi membacanya. Kegiatan dilaksanakan pada tanggal 14 Juni 2021 di SDN 3 Tamansuruh, adapun metode yang digunakan berupa tahap persiapan, pelaksanaan, dan evaluasi. Aktivitas yang dilakukan di antaranya adalah pembuatan rak pojok membaca, pengumpulan buku, pendampingan baca, dan kegiatan lomba-lomba. Dengan adanya kegiatan ini, diharapkan kedepannya anak-anak lebih senang berkunjung dan tertarik membaca buku-buku bacaan.
Radiative closure and cloud effects on the radiation budget based on satellite and ship-borne observations during the Arctic summer research cruise PS106
Authors: Barrientos-Velasco Carola , Deneke Hartwig , Hünerbein Anja , Griesche Hannes J. , Seifert Patric , Macke Andreas
Published: January 2022

Abstract. For understanding Arctic climate change, it is critical to quantify and address uncertainties in climate data records on clouds and radiative fluxes derived from long-term passive satellite observations. A unique set of observations collected during the research vessel Polarstern PS106 expedition (28 May to 16 July 2017) by the OCEANET facility is exploited here for this purpose and compared with the CERES SYN1deg Ed. 4.1 satellite remote sensing products. Mean cloud fraction (CF) of 86.7 % for CERES and 76.1 % for OCEANET were found for the entire cruise. The difference of CF between both data sets is due to different spatial resolution and momentary data gaps due to technical limitations of the set of ship-borne instruments. A comparison of radiative fluxes during clear-sky conditions enables radiative closure for CERES products by means of independent radiative transfer simulations. Several challenges were encountered to accurately represent clouds in radiative transfer under cloudy conditions, especially for ice-containing clouds and low-level stratus (LLS) clouds. During LLS conditions, the OCEANET retrievals were in particular compromised by the altitude detection limit of 155 m of the cloud radar. Radiative fluxes from CERES show a good agreement with ship observations, having a bias (standard deviation) of −6.0 (14.6) W m−2 and 23.1 (59.3) W m−2 for the downward longwave (LW) and shortwave (SW) fluxes, respectively. Based on CERES products, mean values of the radiation budget and the cloud radiative effect (CRE) were determined for the PS106 cruise track and the central Arctic region (70°–90° N). For the period of study, the results indicate a strong influence of the SW flux in the radiation budget, which is reduced by clouds leading to a net surface CRE of −8.8 W m−2 and −9.3 W m−2 along the PS106 cruise and for the entire Arctic, respectively. The similarity of local and regional CRE supports that the PS106 cloud observations can be considered to be representative of Arctic cloudiness during early summer.
Air pollution monitoring: Development of ammonia (NH3) dynamic reference gas mixtures at nmol/mol levels for improving the lack of traceability of measurements
Authors: Macé Tatiana , Iturrate-Garcia Maitane , Pascale Céline , Niederhauser Bernhard , Vaslin-Reimann Sophie , Sutour Christophe
Published: January 2022

Abstract. The measurement of ammonia (NH3) in ambient air is a sensitive and priority topic due to its harmful effects on human health and ecosystems. NH3 emissions have continuously increased over the last century in Europe, because of intensive livestock practices and enhanced use of nitrogen-based fertilizers. European air quality monitoring networks monitor atmospheric NH3 amount fractions. However, the lack of stable reference gas mixtures (RGMs) at atmospheric amount fractions to calibrate NH3 analyzers is a common issue of the networks, which results in data that are not accurate, traceable and, thus, geographically comparable. In order to cover this lack, LNE developed, in close collaboration with the company 2M PROCESS, a gas reference generator to generate dynamically NH3 RGMs in air. The method is based on gas permeation and further dynamic dilution to obtain an amount fraction range between 1 and 400 nmol/mol. The calibration of the elements of the generator against LNE primary standards ensures the traceability of the RGMs to the international system of units. Furthermore, the highly accurate flow and oven temperature measurements of the reference generator, together with the associated calibration procedure defined by LNE, guarantee relative expanded uncertainties of the calibration of the NH3 analyzer calibrations lower than 2 % (coverage factor = 2). This result is very satisfactory considering the low NH3 amount fraction levels (1 to 400 nmol/mol) and the phenomena of adsorption and desorption, especially in the presence of traces of water on the surfaces in contact. A bilateral comparison was organized between METAS and LNE, consisting on the calibration of a PICARRO G2103 gas analyzer by both national metrology institutes (NMI). The results highlighted the good agreement between the NH3 reference generators developed by the two institutes and allowed to validate both LNE’s reference generator and calibration procedure. The development of the NH3 reference generator has already raised great interest within the French air quality monitoring networks (AASQA). Since the end of 2020, LNE calibrated several NH3 analyzers of the networks. These requests shows the interest of the AASQA in the development of this new gas reference generator to guarantee the traceability of measurements carried out on the French territory.
Automating Finite Element Methods for Geodynamics via Firedrake
Authors: Davies D. Rhodri , Kramer Stephan C. , Ghelichkhan Siavash , Gibson Angus
Published: January 2022

Abstract. Firedrake is an automated system for solving partial differential equations using the finite element method. By applying sophisticated performance optimisations through automatic code-generation techniques, it provides a means to create accurate, efficient, flexible, easily extensible, scalable, transparent and reproducible research software, that is ideally suited to simulating a wide-range of problems in geophysical fluid dynamics. Here, we demonstrate the applicability of Firedrake for geodynamical simulation, with a focus on mantle dynamics. The accuracy and efficiency of the approach is confirmed via comparisons against a suite of analytical and benchmark cases of systematically increasing complexity, whilst parallel scalability is demonstrated up to 12288 compute cores, where the problem size and the number of processing cores are simultaneously increased. In addition, Firedrake's flexibility is highlighted via straightforward application to different physical (e.g. complex nonlinear rheologies, compressibility) and geometrical (2-D and 3-D Cartesian and spherical domains) scenarios. Finally, a representative simulation of global mantle convection is examined, which incorporates 230 Myr of plate motion history as a kinematic surface boundary condition, confirming its suitability for addressing research problems at the frontiers of global mantle dynamics research.
A reexamination of the dry gets drier and wet gets wetter paradigm over global land: insight from terrestrial water storage changes
Authors: Xiong Jinghua , Guo Shenglian , Chen Jie , Yin Jiabo
Published: January 2022

Abstract. The “dry gets drier and wet gets wetter” (DDWW) paradigm has been widely used to summarize the expected trends of the global hydrologic cycle under climate change. However, the paradigm is challenged over land due to different measures and datasets, and is still unexplored from the perspective of terrestrial water storage anomaly (TWSA). Considering the essential role of TWSA in wetting and drying of the land surface, here we built upon a large ensemble of TWSA datasets including satellite-based products, global hydrological models, land surface models, and global climate models to evaluate the DDWW hypothesis during the historical (1985–2014) and future (2071–2100) periods under various scenarios. We find that 27.1 % of global land confirms the DDWW paradigm, while 22.4 % of the area shows the opposite pattern during the historical period. In the future, the DDWW paradigm is still challenged with the percentage supporting the pattern lower than 20 %, and both the DDWW-validated and DDWW-opposed proportion increase along with the intensification of emission scenarios. Our findings will provide insights and implications for global wetting and drying trends from the perspective of TWSA under climate change.
Flood generation: process patterns from the raindrop to the ocean
Authors: Blöschl Günter
Published: January 2022

Abstract. This article reviews river flood generation processes and flow paths across space scales. The scale steps include the pore, profile, hillslope, catchment, regional and continental scales, representing a scale range of a total of 10 orders of magnitude. Although the processes differ between the scales, there are notable similarities. At all scales, there are media patterns that control the flow of water, and are themselves influenced by the flow of water. The processes are therefore not spatially random (as in thermodynamics) but organised, and preferential flow is the rule rather than the exception. Hydrological connectivity, i.e. the presence of coherent flow paths, is an essential characteristic at all scales. There are similar controls on water flow and thus on flood generation at all scales, however, with different relative magnitudes. Processes at lower scales affect flood generation at the larger scales not simply as a multiple repetition of pore scale processes, but through interactions, which cause emergent behaviour of process patterns. For this reason, when modelling these processes, the scale transitions need to be simplified in a way that reflects the relevant structures (e.g. connectivity) and boundary conditions (e.g. groundwater table) at each scale. In conclusion, it is argued that upscaling as the mere multiple application of small scale process descriptions will not capture the larger scale patterns of flood generation. Instead, there is a need to learn from observed patterns of flood generation processes at all spatial scales.
Fault slip potential induced by fluid injection in the Matouying EGS field, Tangshan seismic region, North China
Authors: Feng Chengjun , Gao Guangliang , Zhang Shihuai , Sun Dongsheng , Zhu Siyu , Tan Chengxuan , Ma Xiaodong
Published: January 2022

Abstract. The Tangshan region is one of the most seismically active areas in the North China, and the 1976 M 7.8 earthquake occurred on July 28th near the Tangshan fault zone. The Matouying Enhanced Geothermal Systems (EGS) field is located ~90 km away from Tangshan City. Since the late 2020, preliminary hydraulic stimulation tests have been conducted at depths of ~3965–4000 m. Fluid injection into geothermal reservoir facilitates heat exchanger system. However, fluid injection may also induce earthquakes. In anticipation of the EGS operation at the Matouying uplift, it is essential to assess how the fault slip potential of the nearby active and quiescent faults will change in the presence of fluid injection. In this study, we first characterize the ambient stress field in the Tangshan region by performing stress tensor inversions using 98 focal mechanism data (ML ≥ 2.5). Then, we estimate the principal stress magnitudes near the Matouying EGS field by analyzing in situ stress measurements at shallow depths (~600–1000 m). According to these data, we perform a quantitative risk assessment using the Mohr-Coulomb framework in order to evaluate how the main active faults might respond to hypothetical injected-related pore pressure increases due to the upcoming EGS production. Our results mainly show that most earthquakes in the Tangshan seismic region have occurred on the faults that have relatively high fault slip potential in the present ambient stress field. At well distances of less than 15 km, the probabilistic fault slip potential on most of the boundary faults increase with continuing fluid injection over time, especially on these faults with well distances of ~6–10 km. The probabilistic fault slip potential increases linearly with the fluid injection rate. However, the FSP values decrease exponentially with increased unit permeability. The case study of the Matouying EGS field has important implications for the deep geothermal exploitation in China, especially for Gonghe EGS (in Qinghai province) and Xiong’an New Area (in Hebei province) geothermal reservoirs that are close to the Quaternary active faults. Ongoing injection operations in the regions should be conducted with these understandings in mind.
Family Biopsychosocial Characteristics on Stunting Events in Children in Stunting Locus Areas Tapalang Barat District
Authors: Saeni Rahmat Haji , Arief Erdiawati
Published: January 2022

Background: Nutrition in the first five years of life is very important because at this time physical and brain development is most rapid. Nutrition at this time will affect future developments (Data, Information and Health, 2016). Anthropometric monitoring is also needed, as an initial screening of nutritional problems, including stunting and wasting, to facilitate interventions to be carried out to prevent long-term effects and the next stage in the toddler development cycle (Ramos, Dumith and César, 2015). The research method used in this study was case control, while the research was conducted from April to September 2020.
Purpose: This study aims to determine the relationship between biopsychosocial and stunting in children under five years in the stunting locus area, West Tapalang District.
Method: This study uses a case control research design with the number of respondents each as many as 57 people. The sampling method used is total sampling
Results: There is a statistical relationship between exclusive breastfeeding and the incidence of stunting. The p value is 0.01 with an OR value of 0.38. Meanwhile, maternal height has a p value of 0.84 (OR 1.08), family support has a p value of 0.49 (OR 0.49), exposure to cigarette smoke has a p value of 0.09 (OR 0.31) and socioeconomic has no statistical relationship.
Conclusion: There is a relationship between exclusive breastfeeding and the incidence of stunting. Meanwhile, maternal height, family support, and exposure to cigarette smoke did not show a statistical relationship with the incidence of stunting

Key words: Stunting, Toddler, psychosocial.
Degrees of Canal Stenosis, Levels of Interleukin-6 (IL-6) And C-Reactive Protein (CRP) Preoperative as Predictors of the Output of Neurogenic Claudication Outcome Score (NCOS) 8 Weeks Post-Decompression-Stabilization-Fusion in Degenerative Lumbar Spinal Stenosis Patients
Authors: Bimantara Nyoman Gede , Suyasa I Ketut , Wiratnaya I Gede Eka
Published: January 2022

Introduction: Lumbar Spinal Stenosis (LSS) or spinal stenosis is the most common spinal disease in elderly patients. LSS is also one of the leading causes of spinal surgery in the world. The problem that is often encountered is the limited predictor of outcomes that are considered affordable and accurate, so as to provide education to patients about possible output after the surgery process is carried out. Therefore, a predictor is needed that is considered accurate and affordable such as the degree of measurable canal stenosis of Magnetic resonance imaging (MRI), serum levels of C-Reactive Protein (CRP) and Interleukin-6 (IL-6)
Method: This study used a prospective cohort design conducted to compare Neurogenic Claudication Outcome Score scores among people with degenerative lumbar canal stenosis whose post-decompression-stabilization-fusion had higher degrees of canal stenosis (measured through Schizas grading of Magnetic resonance Imaging/MRI) examinations), as well as high pre-operative CRP and IL-6 levels with those with normal CRP and IL-6 levels. From the population of lumbar spinal stenosis, the selection of samples was conducted consecutively sampling. After that, statistical tests in the form of descriptor tests, normality tests, risk factor assessments with 2x2 cross tabulation, and proportion comparison analysis using the Fisher Exact test.
Result: Severe lumbar canal stenosis degrees resulted in worse NCOS 8 weeks postoperative than mild degrees of lumbar canal stenosis, with statistically significant differences (p=0.008; p < 0.05) and RR 6.4 (0.99-41.08). High CRP levels resulted in worse NCOS 8 weeks postoperative than mild lumbar degrees of canal stenosis, with statistically significantly differences (p=0.008; p < 0.05) and RR 6.4 (0.99-41.08). High pre-operative IL-6 levels resulted in worse NCOS 8 weeks postoperative than normal pre-operative IL-6 levels with statistically significantly differences (p=0.002; p < 0.05) and RR 8 (1.24-51.50).
Conclusion: Degrees of preoperative (mild) canal stenosis, high pre-operative CRP levels, and high levels of pre-operative IL-6 were predictors for better 8-week NCOS scores in patients with post-decompression-stabilizing-fusion degenerative LSS disease.

Key words: Degenerative lumbar spinal stenosis, IL-6, CRP, canal degree stenosis, NCOS.
On the origin of runaway binaries: the case of the HMXB 4U 2206+54/BD +53 2790
Authors:   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Hambaryan V. , Stoyanov K. A. ,   Institute of Astronomy and National Astronomical Observatory, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, BG-1784 Sofia, Bulgaria, Mugrauer M. ,   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Neuhäuser R. ,   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Stenglein W. ,   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Bischoff R. ,   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Michel K.-U. ,   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Geymeier M. ,   Astrophysikalisches Institut und Universit¨ats-Sternwarte Jena, Schillerg¨aßchen 2-3, 07745 Jena, Germany, Kurtenkov A. ,   Institute of Astronomy and National Astronomical Observatory, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, BG-1784 Sofia, Bulgaria, Kostov A. ,   Institute of Astronomy and National Astronomical Observatory, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, BG-1784 Sofia, Bulgaria
Published: January 2022

We present most probable place and time of the origin of the runaway high-mass X-ray binary 4U 2206+54 based on its Gaia EDR3 astrometric parameters and our new systemic radial velocity. We studied the trace back motion of the system and propose that it originated in the subgroup of the Cepheus OB1 association (Age∼4-10 Myr) with its brightest star BD+53 2820 (B0V; L∼104.7L⊙). The kinematic age of 4U 2206+54 is about 2.8 ± 0.4 Myr, it is at a distance of 3.1-3.3 kpc and has a space velocity of 75-100 km/s with respect to this member star (BD+53 2820) of the Cep OB1 association. This runaway velocity indicates that the progenitor of the neutron star hosted by 4U 2206+54 lost about 4-9M⊙ during the supernova explosion and the latter one received a kick velocity of at least 200-350 km/s. The high-mass X-ray binary 4U 2206+54/BD+53 2790 was born as a member of a subgroup of the Cep OB1 association, the initially most massive star in the system terminated its evolution within ≲ 7 − 9 Myr, corresponding to an initial mass ≳ 32 M⊙.
Cumhurbaşkanlığı Hükümet Sistemi’nin İdari Teşkilat Yapısı Üzerine Etkisi
Authors: A. FANİD Nematollah (erdal) , AKMAN Ferdanur
Published: January 2022

Ülkemizde gelişen tarihsel süreç içerisinde tıpkı diğer ülkelerde de olduğu gibi birçok hükümet sisteminin varlığı söz konusu olmuştur. Osmanlı imparatorluğu ile başlayan bu süreç Cumhuriyet tarihine kadar olan zaman diliminde monarşi, meşruti monarşi, parlamenter sistem ve başkanlık sistemlerinin sıralandığı hükümet sistemlerinin varlığı ile donatılmıştır. Ülkemizde oldukça uzun bir dönem uygulanan parlamenter hükümet sistemi siyasi krizlere yol açarak eleştirilere sebep olmuştur. Siyaset gündemi içerisinde bu eleştirilere çözüm olarak Başkanlık hükümet sisteminin varlığı sık sık dile getirilmiş ve yapılan 2017 Anayasa değişikliği sonucunda parlamenter hükümet sistemi terk edilerek Cumhurbaşkanlığı Hükümet Sistemi’ne geçilmiştir. Cumhurbaşkanlığı Hükümet Sistemi ile yasama, yürütme ve yargı alanında köklü değişiklikler gerçekleştirilmiş, Cumhurbaşkanlığı kararnameleri aracılığıyla yapılan yeni düzenlemelerle yönetimde istikrar ve verimliliğin arttırılması amaçlanmıştır. Literatür incelemesi yöntemine dayanılarak yapılan bu çalışmanın temel amacı hükümet sistemi değişikliği neticesinde yapılan değişikliklerin idari teşkilat üzerindeki etkilerini incelemek ve kuvvetler ayrılığı ilkesi bağlamında değerlendirmektir. Çalışmada elde edilen temel bulgu; Cumhurbaşkanlığı Hükümet Sistemi’nde yapılan bazı değişikliklerin kuvvetler ayrılığına aykırılık teşkil etmesi ve Cumhurbaşkanlığı kararnamelerinin asli nitelikte bir düzenleyici işlem olmasına rağmen sınırlarının net bir şekilde belirlenmemiş olmasıdır. Bu bağlamda Anayasa değişikliği neticesinde yeniden düzenlenen yasama yürütme ve yargı organlarının yapı ve işleyişinde aksaklığa sebep olan sorunların ortadan kaldırılması gerekmektedir.
Proinflammatory adipokines and cytokines in abdominal obesity as a factor in the development of atherosclerosis and renal pathology
Authors: Ryabova E. A. , Ragino I. Y.
Published: January 2022

In recent decades, there has been an increase in the prevalence of overweight and obesity. Obesity has become an underestimated pandemic and a public health threat around the world. Adipose tissue is positioned as an endocrine organ that secretes a wide range of pro-inflammatory cytokines and adipokines, inducing a state of chronic subinflammation. The results of epidemiological studies over the past 30 years have also shown that visceral adipose tissue is an independent risk factor for the development of atherosclerosis, cardiometabolic diseases and chronic kidney disease. We performed a systematic review to summarize important aspects of the state of chronic subinflammation in the context of its effect on the decrease in glomerular filtration rate and the development of chronic kidney disease. The review deals with the etiology and pathogenesis of obesity, the hormonal profile of adipose tissue, the molecular mechanisms of the effect of pro-inflammatory cytokines and adipokines on the kidneys, and the pathophysiology of renal diseases. Information on the topic from publications based on the Pubmed database has been used.
Association of lipid profile parameters, atherogenic index of plasma, anthropometric parameters with the severity of the COVID-19 course in Novosibirsk women
Authors: Evdokimova N. E. , Striukova E. V. , Maslatsov N. A. , Khudyakova A. D. , Volkova M. V. , Logvinenko I. I.
Published: January 2022

Background: Our study aimed to assess the relationship between the parameters of the lipid profile, atherogenic index of plasma (AIP), anthropometry influence with the severity of the new coronavirus infection COVID-19 in women. Material and methods. The study design was a cross-sectional study. The research included 138 women aged 29–82 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 61), moderate (n = 70) and severe (n = 7). Body mass index, waistline and hip circumference, waistline circumference to hip circumference index, total cholesterol, triglycerides, HDL, LDL, AIP were calculated. Statistical processing of the obtained results was carried out using the SPSS software package (version 20.0) using the Mann-Whitney test, univariate logistic regression analysis, Pearson chi-squared test. Results. The levels of HDL-cholesterol were significantly lower in group 3 compared with the level of HDL-cholesterol in women in group 2 (p2-3 = 0.046). BMI was higher in the moderately severe group compared to the mild one (26.32 [23.305; 30.4] versus 28.78 [24.72; 34.77], p1-2 = 0.026). Hip circumference was higher in patients with severe COVID-19 than in patients with mild course (104 [98; 112] versus 114 [109.5; 126], p1-3 = 0.039), AIP was higher in women with severe course compared to women with moderate and mild course (p1-3 = 0.043, p2-3 = 0.04). The results of the logistic regression analysis showed that the moderate course of COVID-19 is associated with BMI (OR = 1.09, 95 % CI 1.019–1.166, p1-2 = 0.012), and the severe course with WC (OR = 1.041, 95 % CI 1.001–1.084, p1-3 = 0.046), AIP value ≥ 0.11 (OR = 13.824, 95 % CI 1.505–126.964, p1-3 = 0.02; OR = 11,579, 95 % CI 1,266–105,219, p2-3 = 0.03) and HDL level < 40 mg/dl (OR = 14,750, 95 % CI 2,317–93,906, p1-3 = 0.004; OR = 8,000, 95 % CI 1,313– 48,538, p1-3 = 0.024). Conclusion. Patients from the group with moderate and severe course of the new coronavirus infection have higher body mass index, hip circumference, AIP, lower HDL values. The chance of a moderate course of COVID-19 is associated with an increased BMI value, and a severe course with WC, AIP ≥ 0.11 and HDL level < 40 mg/dl.
Associations of polymorphisms of some genes with excessive weight in a population sample of young citizens of Novosibirsk
Authors: Denisova D. V. , Gurazheva A. A. , Maximov V. N.
Published: January 2022

Aim of the study was to investigate the associations of polymorphisms of some genes with overweight and some anthropometric and biochemical indicators in a population sample of the young population of Novosibirsk. Material and methods. The study was carried out on a sample of young people aged 25–35 years, residents of Novosibirsk, selected by the method of random numbers (n = 319). During the survey, a questionnaire was filled out, anthropometric measurements, blood sampling, followed by biochemical and molecular genetic studies were carried out. Results. The odds ratio (OR) to detect a carrier of the AA rs9939609 genotype of the FTO gene in the group with an increased body mass index (BMI) compared to the group with a normal BMI is 2.1 times higher (95% confidence interval (95 % CI) 1.2– 3.8; p = 0.019 in the AA vs AT+TT model). In the Kruskal – Wallis test in the general group, differences were found in carriers of different rs9939609 genotypes of the FTO gene in the thickness of the skin fold in the middle third of the right shoulder (p = 0.0008) and under the right shoulder blade (p = 0.026). In carriers of the AA genotype, these indicators were noticeably higher compared to carriers of the AT and TT genotypes. Differences in high density lipoprotein cholesterol were found in women (p = 0.032; the lowest level in the AA genotype) and low density lipoprotein cholesterol (p = 0.027; the highest value in the AA genotype). In addition, female carriers of the TT rs7903146 genotype of the TCF7L2 gene had lower diastolic blood pressure than carriers of the CT and CC genotypes (p = 0.027). The probability of detecting a male carrier of the CT or TT genotypes of the TCF7L2 gene polymorphism rs7903146 in the obese group is 0.313 (95 % CI 0.102–0.955; p = 0.036 in the CC vs CT+TT model) compared with the group with excess BMI (25 ≤ BMI < 30 kg/m2 ). The probability of detecting the allele with rs10811661 of the CDKN2AB gene in the obese group is 2.2 times higher (95 % CI 1.1–4.5; p = 0.035) compared with the group with an excess BMI. Conclusion. The association of overweight in the population sample of the young population of Novosibirsk was confirmed with rs9939609 of the FTO gene, rs7903146 of the TCF7L2 gene, rs10811661 of the CDKN2AB gene. The association of rs2237892 of the KCNQ1 gene and rs1111875 of the HHEX gene with overweight was not found. Associations of the studied SNPs with some anthropometric and biochemical indicators were found.
Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk
Authors: Spiridonov A. N. , Denisova D. V. , Ragino Y. I.
Published: January 2022

The study was devoted to the study of the prevalence of hypercholesterolemia (hyper-Chol) and hypercholesterolemia of low density lipoproteins (hyper-LDL-C) against the background of abdominal obesity (AO) in a population aged 25–44 years in Novosibirsk. Material and methods. A crosssectional survey of the population aged 25–44 years in Novosibirsk (Russia) was carried out. 1415 people were examined, including 670 men (47.3 %) and 745 women (52.7 %), pregnant women or being on maternity leave were not included in the study). All subjects were assessed for the presence of AO, hyper-Chol and hyper-LDL-C. Results. Individuals with AO had higher average values of total cholesterol and LDL cholesterol. The prevalence of hyper-Chol in individuals with AO was 1.3 times higher and hyper-LDL-C – 1.2 times higher than in individuals without AO. In women with AO, the prevalence of hyper-Chol was 1.2 times higher and hyper-LDL-C – 1.3 times higher than in women without AO. In men with AO, the prevalence of hyper-Chol was 1.4 times higher and hyper-LDL-C – 1.2 times higher than in men without AO. When conducting logistic regression analysis, it was found that in a young population under 45 years of age, abdominal obesity was significantly associated with the presence of atherogenic hypercholesterolemia in both sexes. In men, significant associations of AO with both hyper-Chol and hyper-LDL-C were noted, in women – only with hyper-LDL-C. Conclusions. A population study of young people (25–44 years old) revealed associations of atherogenic hypercholesterolemia with abdominal obesity.
Clinical case of myocardial infarction with unspecified familial hypercholesterolemia
Authors: Lozhkina N. G. , Spiridonov A. N.
Published: January 2022

Familial hypercholesterolemia is a hereditary autosomal dominant disease characterized by a violation of cholesterol metabolism. This nosology was first described in the late 1930s by the Norwegian clinician Karl Moeller, he proposed the idea that hypercholesterolemia and tendon xanthomas are associated with cardiovascular diseases through the inheritance of a single gene. In 1964, two clinical phenotypes of familial hypercholesterolemia were discovered: heterozygous and homozygous, associated with an unfavorable prognosis. To date, it is known that the long-running process of accumulation of low-density lipoproteins in the intima of blood vessels may not have clinical symptoms for many years due to the developed system of collaterals and the absence of hemodynamically significant stenosis. However, without timely diagnosis and appropriate therapy, this condition inevitably leads to the development of a cardiovascular event. The article presents a clinical case demonstrating the development of myocardial infarction in a patient with a late diagnosis of this disease.
micrOMEGAS - a code for calculating dark matter properties
Authors: Belanger Genevieve
Published: January 2022

micrOMEGAs is a code for the calculation of Dark Matter Properties in generic models of New Physics. In particular it allows to compute the relic density of dark matter, the rates for direct and indirect detection of dark matter as well as the prediction for dark matter production at colliders. In this talk I will first present the evidence for dark matter and describe the motivation for having a code that automatically computes the signatures and constraints on a new weakly interacting dark matter particle. After describing the general structure of the code. I will discuss issues related to the computation of the dark matter relic density, a well measured observable, as well as the computation of the rate for dark matter scattering on nucleus relevant for direct detection. A few extensions of the basic features of the code will be mentioned.
Subchronic oral toxicity of Rabella powder in experimental rats
Authors: Van Anh Pham Thi , Ha Tran Thai , Nguyet Ta Minh , Hang Dinh Thi Thu
Published: January 2022

It has recently become obvious that the prevalence of obesity has been rapidly increasing in Vietnam, as well as other countries, over the past two decades. There has been a current trend for researchers to discover new natural ingredients which are safe and effective in the treatment of obesity. RABELLA powder was a herbal-derived product which contained Amorphophalus konjac (K. Koch starch). This plant was used as an oral medication for controlling body weight in the past as well as in the present. So far, the safety of this product, has not been reported yet in Vietnam. Thus, this study was designed to assess the subchronic toxicity of RABELLA powder in Wistar rats. The method used in this study followed the guidance of the World Health Organization and Organization for Economic Co-operation and Development; 2 oral doses of 1.2 g/kg b.w/day and 3.6 g/kg b.w/day was administered to rats for 12 consecutive weeks. The results show that RABELLA powder caused no significant change in the general condition, hematological indexes, functions and microscopic images of livers and kidneys. We conclude that RABELLA powder did not cause subchronic toxicity in experimental rats. Moreover, this also revealed partly the safety of RABELLA powder in clinical practice.
Efficacy and safety of Trang Phuc Linh Plus tablets in patients with irritable bowel syndrome-diarrhea
Authors: Van Anh Pham Thi , Thanh Nguyen Phuong , Duong Dau Thuy , Thuy Nguyen Thi , Mai Dang Thi Ngoc , Chi Nguyen Duc Linh , Thai Nguyen Quang , Ba Hoang Xuan , Huong Hoang Thi , Anh Tran Ngoc , Thanh Duong Cong , Phuong Anh Nguyen Thi
Published: January 2022

A double-blind, randomized, phase II clinical trial was conducted within a 14-week follow-up including 2 weeks of the non-drug run-in period, 8 weeks of medication, and 4 weeks of follow-up after discontinuation. The objective of the study was to evaluate the efficacy and safety of Trang Phuc Linh Plus in irritable diarrhea syndrome patients. Group I took Trang Phuc Linh Plus 3 tablets/time x 2 times/day for 8 weeks; Group II took placebo 3 tablets/time x 2 times/day for 8 weeks. Patients will be re-examined, tested, and evaluated over the phone for symptom recurrence and adverse events (AEs). This study showed that the Trang Phuc Linh Plus tablets tended to improve symptoms in patients suffering from irritable bowel syndrome with diarrhea, suggesting its safety and tolerability.
Cerebral venous sinus thrombosis related to vaccine-induced immune thrombotic thrombocytopenia: First reported case in Vietnam
Authors: Hai Hoang Bui , Phuc Do Giang , Chung Nguyen Thanh , My Tran Thi Kieu , Xuan Le Thi Thanh , Dinh Michael D , Hieu Nguyen Lan
Published: January 2022

Vaccination remains one of the most important public health interventions to control and mitigate the impacts of COVID-19 worldwide. A number of post-vaccination reactions have caused concern and are the cause of vaccine hesitancy. Vaccine-induced immune thrombotic thrombopenia (VITT) has been reported in several countries such as Norway at a rate of 1 per 26000 doses of the ChAdOx1 nCoV vaccine (AstraZeneca), 15 per 8 million doses of Ad26.COV2.S (Janssen; Johnson & Johnson) vaccines in the US. In Vietnam, 11.5 million doses of AstraZeneca vaccine have been administered since the commencement of a nation-wide vaccination program five months ago. We report the first case of cerebral venous thrombosis related to VITT which was promptly diagnosed and successfully treated with rivaroxaban alone. Thus, VITT is very rare in Vietnamese people vaccinated with the AstraZeneca vaccine in the prevention of COVD-19 infection.
Sub-chronic oral toxicity study of “Kien Nao Dan” tablets in experimental animal
Authors: Hong Trinh Thi Thuy , Xuan Le Thanh , Minh Tran Quang , Hang Vu Viet , Van Anh Pham Thi , Hien Dang Thi Thu
Published: January 2022

“Kien nao dan” (KND) tablet is composed of 13 traditional medicines that may has preventive and effective treatment of cerebral ischemia. However, there are no scientific reports of its toxicological properties which guarantee of the safety its usage treatment. Therefore, the aim of this study was to investigate the sub-chronic toxicity of KND tablet on rats through oral administration. The sub-chronic toxicity was evaluated by the recommendation of WHO in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological changes or signs of toxicity. The result of the hematological and biological parameters after administration of KND tablets showed no change. The histopathologic analysis of livers and kidneys indicated that no significant differences were observed between the exposed and unexposed rat groups. In conclusion, “Kien nao dan” tablets did not produce sub-chronic toxicity in Wistar rats.
Sub-chronic oral toxicity study of “Phong Thap Dan” tablets in experimental animal
Authors: Xuan Le Thanh , Ngoc Le Thi Nhat , Minh Tran Quang , Hang Vu Viet , Van Anh Pham Thi , Hien Dang Thi Thu
Published: January 2022

The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological change or sign of toxicity. The result of the hematological and biological parameters after administration of PTD tablets showed no change. The histopathology analysis of livers and kidneys indicated that no significant difference was observed between the exposed and unexposed rat groups. In conclusion, “Phong thap dan” tablets did not produce sub-chronic toxicity in Wistar rats.
A case of primary breast diffuse large B cell lymphoma
Authors: Huy Trinh Le , Anh Tran Dinh
Published: January 2022

Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin’s lymphoma with limited data. We here report a case of primary breast diffuse large B-cell lymphoma mimicking breast cancer. A 52-year-old woman had a painless mass in her right breast. Fine needle aspiration cytology and core biopsy were performed which suggested malignant features but could not confirm the specific subtype. Excisional biopsy then was conducted revealing non-Hodgkin lymphoma, which was subsequently confirmed with histopathology and diagnosed as diffuse large B-cell lymphoma (DLBCL). A chest computed tomography scan revealed a 3.5 cm sized breast mass with skin thickening and modest lymphadenopathy in the ipsilateral axilla. The patient received six courses of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab) chemotherapy, then whole breast radiation (30Gy in 15 fractions). At 12 months of follow-up, the patient survives with no evidence of disease. No morbidities occurred in this patient during the follow-up period. We briefly review the current practice pattern in patients with primary breast diffuse large B-cell lymphoma.