bluuebunny/crossref_metadata_2025 huggingface dataset:
US State-Level Legislative Responses to the Ebola Outbreak, 2014-2015
Authors: Rutkow Lainie , Jabs Alexandra
Published: June 2016

Objective

We sought to systematically identify and analyze state-level legislative responses to Ebola from April 2014 through June 2015.

Methods

Using standardized search terms, we searched the LexisNexis State Capital database to identify bills or resolutions that explicitly mentioned Ebola or viral hemorrhagic fever in all 50 US states and Washington, DC, from April 2014 through June 2015. Information was abstracted from relevant bills or resolutions by using an electronic data collection form. Abstracted information was analyzed to identify themes and patterns.

Results

Our search processes returned 273 bills and resolutions; 17 met our inclusion criterion. These 17 bills and resolutions were introduced in 11 states. The primary goals of these materials concerned the following: protecting or acknowledging public health and health care workers (n=4), revising the definition of “communicable disease” (n=3), financial considerations (n=5), establishing a task force (n=2), and updating or creating facilities (n=3). Six bills were enacted and 4 resolutions were adopted.

Conclusion

Approximately 20% of the states introduced bills or resolutions concerning the Ebola outbreak. These bills and resolutions highlight important practice considerations, including protections for those who assist in treating Ebola and revision of laws in the face of emerging infectious disease threats. Policy-makers and emergency planners would benefit from incorporating lessons learned from states’ Ebola responses into their preparedness activities. (Disaster Med Public Health Preparedness. 2016;10:649–653)
Cardiac Electrophysiology Laboratories: A Potential Target for Antimicrobial Stewardship and Quality Improvement?
Authors: Branch-Elliman Westyn , Stanislawski Maggie , Strymish Judith , Barón Anna E. , Gupta Kalpana , Varosy Paul D. , Gold Howard S. , Ho P. Michael
Published: June 2016

BACKGROUND

Infections following cardiovascular implantable electronic device (CIED) procedures, including pacemaker and implantable cardioverter–defibrillators, are devastating and costly. Preimplantation prophylactic antimicrobials are effective for reducing postprocedural infections. However, routine postprocedural antimicrobials are not associated with improved outcomes, and they may be harmful. Thus, we sought to characterize antimicrobial use patterns following CIED procedures.

DESIGN

All patients who underwent CIED procedures from October 1, 2007 to September 30, 2013 and had procedural information entered into the VA Clinical Assessment Reporting and Tracking (CART) software program were included in this study. All antibiotic prescriptions lasting more than 24 hours following device implantation or revision were identified using pharmacy databases, and postprocedural antibiotic use lasting more than 24 hours was characterized.

RESULTS

In total, 3,712 CIED procedures were performed at 34 VA facilities on 3,570 patients with a mean age of 71.7 years (standard deviation [SD], 11.1 years), 98.4% of whom were male. Postprocedural antibiotics >24 hours were prescribed following 1,579 of 3,712 CIED procedures (42.5%). The median duration of therapy was 5 days (interquartile range [IQR], 3–7 days). The most commonly prescribed antibiotic was cephalexin (1,152 of 1,579; 72.9%), followed by doxycycline (118 of 1,579; 7.47%) and ciprofloxacin (93 of 1,579; 5.9%). Vancomycin was used in 73 of 1,579 prescriptions (4.62%). Among the highest quartile of procedural volume, prescribing practices varied considerably, ranging from 3.2% to 77.6%.

CONCLUSIONS

Nearly 1 in 2 patients received prolonged postprocedural antimicrobial therapy following CIED procedures, and the rate of postprocedural antimicrobial therapy use varied considerably by facility. Given the lack of demonstrated benefit of routine prolonged antimicrobial therapy following CIED procedures, antimicrobial use following cardiac device interventions may be a potential target for quality improvement programs and antimicrobial stewardship.

Infect Control Hosp Epidemiol2016;37:1005–1011
Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship—Observational Studies
Authors: Snyder Graham M. , Young Heather , Varman Meera , Milstone Aaron M. , Harris Anthony D. , Munoz-Price Silvia
Published: June 2016

Observational studies compare outcomes among subjects with and without an exposure of interest, without intervention from study investigators. Observational studies can be designed as a prospective or retrospective cohort study or as a case-control study. In healthcare epidemiology, these observational studies often take advantage of existing healthcare databases, making them more cost-effective than clinical trials and allowing analyses of rare outcomes. This paper addresses the importance of selecting a well-defined study population, highlights key considerations for study design, and offers potential solutions including biostatistical tools that are applicable to observational study designs.

Infect Control Hosp Epidemiol 2016;1–6
The Relationship Between Sedatives, Sedative Strategy, and Healthcare-Associated Infection: A Systematic Review
Authors: Caroff Daniel A. , Szumita Paul M. , Klompas Michael
Published: June 2016

BACKGROUND

Healthcare-associated infections (HAIs) cause significant morbidity in critically ill patients. An underappreciated but potentially modifiable risk factor for infection is sedation strategy. Recent trials suggest that choice of sedative agent, depth of sedation, and sedative management can influence HAI risk in mechanically ventilated patients.

OBJECTIVE

To better characterize the relationships between sedation strategies and infection.

METHODS

Systematic literature review.

RESULTS

We found 500 articles and accepted 70 for review. The 3 most common sedatives for mechanically ventilated patients (benzodiazepines, propofol, and dexmedetomidine) have different pharmacologic and immunomodulatory effects that may impact infection risk. Clinical data are limited but retrospective observational series have found associations between sedative use and pneumonia whereas prospective studies of sedative interruptions have reported possible decreases in bloodstream infections, pneumonia, and ventilator-associated events.

CONCLUSION

Infection rates appear to be highest with benzodiazepines, intermediate with propofol, and lowest with dexmedetomidine. More data are needed but studies thus far suggest that a better understanding of sedation practices and infection risk may help hospital epidemiologists and critical care practitioners find new ways to mitigate infection risk in critically ill patients.

Infect Control Hosp Epidemiol2016;1–9
REVIEW ESSAY: THE SAFETY VALVE ANALOGY IN CHINESE POLITICS
Authors: Chen Dan
Published: June 2016

Studies on Chinese politics frequently utilize the safety valve analogy to describe various political decisions that allow space for feedback and challenges. Drawing upon these empirical studies and the theoretical literature on institution, authoritarianism, and democratization, this review essay delineates the logic of the safety valve strategy and how it fits into the scheme of prolonging authoritarian rule. It identifies the use of informal and temporary measures to appease aggrieved citizens as the central feature of the safety valve strategy, complementing formal means such as institutional reform. The informal and temporary measures are different from the patronage system, and credibility is not necessarily a prerequisite for effectiveness. The safety valve strategy contributes to authoritarian resilience by relieving public frustration, reducing the propensity to contentious politics, and in some cases enabling the government to collect information on potential opposition groups or emerging problems.
Mismatch in cerebral blood flow and glucose metabolism after the forced swim stress in rats
Authors: Kameno Yosuke , Suzuki Katsuaki , Takagai Shu , Iwata Keiko , Matsuzaki Hideo , Takahashi Kenji , Wakuda Tomoyasu , Iwata Yasuhide , Magata Yasuhiro , Mori Norio
Published: June 2016

Objective

Neuroimaging studies of depression considered as a stress-related disorder have shown uncoupling in regional cerebral blood flow (rCBF) and regional cerebral metabolic rate for glucose (rCMRglc). We hypothesised that the mismatch change of rCBF and rCMRglc could be a stress-related phenomenon.

Methods

We exposed male rats to 15-min period of forced swim (FS), followed by the measurement of rCBF using N-isopropyl-4-[123I] iodoamphetamine (123I-IMP) and rCMRglc using 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG).

Results

The uptake rate of 18F-FDG in the FS group showed a significant decrease in the prefrontal cortex (0.86±0.20%ID/g, p<0.01) and thalamus (0.77±0.17%ID/g, p<0.05) and tended to be lower in the hippocampus (0.58±0.13%ID/g) and cerebellum (0.59±0.13%ID/g) without overt alteration in the uptake rate of 123I-IMP.

Conclusions

The FS stress can cause mismatch change of rCBF and rCMRglc, which reflect a stress-related phenomenon.
All Economics is Local: Spatial Aggregations of Economic Information
Authors: Fortunato David , Swift Clint S. , Williams Laron K.
Published: June 2016

National economic indicators play a foundational role in political economic research, particularly in regards to electoral politics. Yet, scholars have failed to recognize that national economic indicators are simply aggregations of local economic information, and the manner in which they are aggregated may not be consistent with the process voters use to acquire, access, and incorporate economic information. We argue that the economic similarities among localities, and the way in which the media report on these similarities, provide more theoretically satisfying means of specifying how local information aggregates into an overall portrait of the national economy. We introduce a novel estimation procedure called the spatial-X ordered logit that offers the chance to model how voters’ evaluations respond to changes in contextualized economic information. Our results support our theory that voters incorporate economic information from other localities with similarly structured economies and in ways that are shaped by media messages. Furthermore, these two specifications offer greater explanatory power than national indicators and other geographical means of aggregating economic information. We conclude by offering a number of implications for research questions ranging from electoral accountability to spatial diffusion processes.
The Limits of Political Representation
Authors: SCHWEBER HOWARD
Published: June 2016

A representation is always a selective and limited reproduction of the thing represented, an idea captured in the metaphor of a map. What is left out of a representation is as important as what is included. A specifically political conception of representation implies limits to the scope of that conception, the nature and character of the represented constituency, and the relationship between constituent and representative, irrespective of variations in institutional design and practice. The limits of political representation reflect normative commitments; consequently, a focus on those limits is central to an evaluation of representative practices. While it is important to look beyond familiar institutional forms, excessively inclusive descriptions of “representative,” “constituency,” or “representation” deprive those conceptions of their substantive content. The limits of political representation are not defects to be overcome by an ever-expanding definition of representation, they are an essential focus in the normative or empirical analysis of representative institutions and practices.
The cilium: a cellular antenna with an influence on obesity risk
Authors: Mariman Edwin C. M. , Vink Roel G. , Roumans Nadia J. T. , Bouwman Freek G. , Stumpel Constance T. R. M. , Aller Erik E. J. G. , van Baak Marleen A. , Wang Ping
Published: June 2016

Primary cilia are organelles that are present on many different cell types, either transiently or permanently. They play a crucial role in receiving signals from the environment and passing these signals to other parts of the cell. In that way, they are involved in diverse processes such as adipocyte differentiation and olfactory sensation. Mutations in genes coding for ciliary proteins often have pleiotropic effects and lead to clinical conditions, ciliopathies, with multiple symptoms. In this study, we reviewed observations from ciliopathies with obesity as one of the symptoms. It shows that variation in cilia-related genes is itself not a major cause of obesity in the population but may be a part of the multifactorial aetiology of this complex condition. Both common polymorphisms and rare deleterious variants may contribute to the obesity risk. Genotype–phenotype relationships have been noticed. Among the ciliary genes, obesity differs with regard to severity and age of onset, which may relate to the influence of each gene on the balance between pro- and anti-adipogenic processes. Analysis of the function and location of the proteins encoded by these ciliary genes suggests that obesity is more linked to activities at the basal area of the cilium, including initiation of the intraflagellar transport, but less to the intraflagellar transport itself. Regarding the role of cilia, three possible mechanistic processes underlying obesity are described: adipogenesis, neuronal food intake regulation and food odour perception.
FERTILIZATION STRATEGIES IN CONSERVATION AGRICULTURE SYSTEMS WITH MAIZE–LEGUME COVER CROP ROTATIONS IN SOUTHERN AFRICA
Authors: MUPANGWA W. , THIERFELDER C. , NGWIRA A.
Published: June 2016

Multilocation experiments were established to determine the best strategy for using inorganic fertilizer in conservation agriculture (CA) systems that use green manure cover crops, namely sunhemp, velvet bean and cowpea grown in rotation with maize. The objectives of the study were to determine (i) the effect of half and full rates of basal fertilizer on maize and legume biomass yields, (ii) the residual effects of unfertilized, half and fully fertilized green manure legumes on maize grown after the legumes, and (iii) the residual effect of unfertilized, half and fully fertilized green manure legumes combined with basal and topdressing fertilizer on maize yields. Experimental design was a randomized complete block with basal fertilizer as a treatment in the green manure legumes phase. Previously, in the maize phase, green manure legume species were the main treatment with basal fertilizer as a subtreatment (sunhemp, velvet bean and cowpea: 0, 75, 150 kg ha−1and 0, 50, 100 kg ha−1, respectively). Nitrogen was applied in the maize phase at 0, 23, 46, 69 kg N ha−1as a sub-subtreatment in Malawi. Results showed that inorganic fertilizer is the most effective when applied to the maize, not green manure legumes. Biomass of green manure legumes, sunnhemp 8084 kg ha−1, velvet bean 7678 kg ha−1and cowpea 4520 kg ha−1, was not significantly affected by application of basal fertilizer. Maize production increased after the application of green manure legumes with maize-after-maize, maize-after-velvet bean, maize-after-sunnhemp and maize-after-cowpea, yielding 3804, 5440, 5446 and 5339 kg ha−1, respectively. Nitrogen increased maize yield regardless of the previously used green manure legumes species. Our results suggest that farmers should apply fertilizer to maize and grow green manure legumes on residual soil in CA systems. Despite growing green manure legumes, smallholders should apply nitrogen topdressing to maize grown using the green manure legumes in some agro-ecologies.
The enigmatic bivalve genus Paramya (Myoidea: Myidae): symbiotic association of an East Asian species with spoon worms (Echiura) and its transfer to the family Basterotiidae (Galeommatoidea)
Authors: Goto Ryutaro , Ishikawa Hiroshi , Hamamura Yoichi
Published: June 2016

Paramya is an enigmatic genus of Myidae (Bivalvia: Heterodonta: Myoidea) that includes three uncommon species: Paramya subovata (Conrad, 1845), Paramya recluzi (A. Adams, 1864) and Paramya africana Cosel, 1995. Paramya subovata is known as a commensal living in the burrow of the spoon worm Thalassema hartmani Fisher, 1947 (Annelida: Echiura: Thalassematidae), in North American coastal waters. However, the biology of the other two species remains unknown. In this study, we found P. recluzi living in the burrows of the two thalassematid echiuran species, Ikedosoma gogoshimense (Ikeda, 1904) and Arhynchite hayaoi Tanaka & Nishikawa, 2013, in intertidal flats in the Seto Inland Sea, Japan. Paramya recluzi was embedded in the burrow wall with its short siphons protruding into the host burrow lumen for respiration and filter feeding. To determine the phylogenetic position of P. recluzi, we performed a molecular phylogenetic analysis using the 18S, 28S, COI and H3 genes. Molecular analysis showed that P. recluzi belongs not to the family Myidae, but to the genus Basterotia (Galeommatoidea: Basterotiidae). Morphological examination of P. recluzi revealed that this species has many similarities with Basterotia (e.g. a single cardinal tooth on each valve and short siphons surrounded by tentacles). Thus, we propose that this species should be transferred from the genus Paramya to Basterotia. In addition, we also suggest that the other two species of Paramya (P. subovata and P. africana) should be transferred to the family Basterotiidae based on their shell morphology, anatomy and ecological characteristics.
Payments for ecosystem services in Indonesia
Authors: Suich Helen , Lugina Mega , Muttaqin Muhammad Zahrul , Alviya Iis , Sari Galih Kartika
Published: June 2016

Payments for ecosystem services schemes are viewed as having the potential to achieve positive biodiversity and ecosystem service outcomes and social outcomes, and they have been widely studied since their development in the 1990s. We describe the state of payments for ecosystem services in Indonesia, where nine schemes were identified, four involving water and five involving carbon. We also assess the perceptions of stakeholders (donors, government, and non-government agencies) regarding the status of such schemes in Indonesia, and their views on what factors support or constrain their development. The main factors perceived to support payments for ecosystem services schemes were easily identifiable ecosystem services and service users, and the long-term support provided by individuals or institutions that facilitate the schemes, building on existing relationships between communities and these facilitating agencies. Stakeholders identified problems relating to regulation: the lack of regulation specifically in relation to payments for ecosystem services, but also overlap and uncertainties regarding regulations. Other constraining factors identified were the lack of recognition of environmental problems amongst potential buyers, and issues of rights and tenure for local communities. With so few operational programmes to date, covering a relatively small land area, and such constraints to further development, payments for ecosystem services schemes appear to have limited scope to supply ecosystem services successfully and sustainably at scale.
Ageing, corporeality and social divisions in later life
Authors: GILLEARD CHRIS , HIGGS PAUL
Published: June 2016

This paper concerns the social divisions of later life. Although research in this field has focused on class, gender and, more recently, sexuality as sources of division in later life, the division between the fit and the frail has tended to be ignored or viewed as an outcome of these other divisions. This paper challenges this assumption, arguing that corporeality constitutes a major social division in later life. This in many ways prefigures a return to the 19th-century categorisation of those ‘impotent through age’, whose position was among the most abject in society. Their ‘impotence’ was framed by an inability to engage in paid labour. Improved living standards during and after working life saw age's impotence fade in significance and in the immediate post-war era, social concern turned towards the relative poverty of pensioners. Subsequent demographic ageing and the expanding cultures of the third age have undermined the homogeneity of retirement. Frailty has become a major source of social division, separating those who are merely older from those who are too old. This division excludes the ‘unsuccessfully’ aged from utilising the widening range of material and social goods that characterise the third age. It is this social divide rather than those of past occupation or income that is becoming a more salient line of fracture in later life.
Participation in advanced age: enacting values, an adaptive process
Authors: SUGARHOOD PAUL , EAKIN PAMELA , SUMMERFIELD-MANN LYNN
Published: June 2016

The concept of participation, introduced through models such as the International Classification of Functioning, Disability and Health, has become increasingly important in health and social care. However, it has not been consistently defined or operationalised, and there is very limited research into participation in the context of advanced age and disability. This article reports a study which explored participation from the perspectives of community-living people aged over 80 years with physical rehabilitation needs. Using a grounded theory methodology, 11 participants aged 81–96 years were recruited from a National Health Service Trust in the United Kingdom. The main finding was that participation was experienced as the enacting of values. Values provided the motivation for specific ways of participating in life, guided actions and behaviours, and were the means through which participation was interpreted. Commonly enacted values were: connecting with others; maintaining autonomy; affirming abilities; doing the best you can; being useful; maintaining self-identity; and pursuing interests. A process was evident whereby participation was challenged by deteriorating health and losses and the participants adapted (or not) to overcome these challenges. To promote participation in advanced age, health and social care policy and practice must consider the values important to older people. Interventions should be congruent with these values and promote strategies through which they can be enacted.
Direct and indirect influences of socio-economic position on the wellbeing of older adults: a Structural Equation Model using data from the first wave of the Irish Longitudinal Study on Ageing
Authors: PRATSCHKE JONATHAN , HAASE TRUTZ , McKEOWN KIERAN
Published: June 2016

The authors use Structural Equation Modelling techniques to analyse the determinants of wellbeing amongst older adults using data from the first wave of the Irish Longitudinal Study on Ageing (TILDA), a rich source of data on people aged over 50 and living in private households. The analysis uses a two-group linear statistical model to explore the influence of socio-economic position on the wellbeing of men and women, with Full Information Maximum Likelihood estimation to handle missing data. The fit indices for the final model are highly satisfactory and the measurement structure is invariant by gender and age. The results indicate that socio-economic position has a significant direct influence on wellbeing and a strong indirect influence which is mediated by health status and lifestyle. The total standardised effect of Socio-economic Position on Socio-emotional Wellbeing is statistically significant (p⩽ 0.05) and equal to 0.32 (men) and 0.43 (women), a very strong influence which risks being underestimated in standard multivariate models. The authors conclude that health, cognitive functioning and wellbeing reflect not just the ageing process, but also the impact of social inequalities across the lifecourse and how they are transmitted across different life spheres. These results can help to orient future research on factors which mediate between socio-economic position and wellbeing, an important policy-related issue.
Dropping in and dropping out: experiences of sustaining and ceasing amateur participation in classical music
Authors: Pitts Stephanie E. , Robinson Katharine
Published: June 2016

The benefits of lifelong musical participation have been repeatedly demonstrated through research and anecdote, and yet the challenging question of why more people are not engaged in these activities is rarely addressed. This project used interviews with eighteen current and past amateur ensemble members to explore themes of social acceptance, musical satisfaction and confidence, and to consider how personal determination and circumstances affect adults’ continuation of musical activities in the face of competing demands. By understanding how musical participation is viewed by those who no longer engage, or who have had long gaps in their engagement, the research aimed to reconsider the challenges of sustaining participation, and the perceived long-term effects of musical learning and experience. Conclusions are drawn about the role of music education in laying foundations for lifelong participation, and the benefits of providing all children with experience and understanding of making music.
Measuring the Consequences of Rules: A Reply to Smith
Authors: YEO SHANG LONG
Published: June 2016

In ‘Measuring the Consequences of Rules’, Holly Smith presents two problems involving the indeterminacy of compliance, which she takes to be fatal for all forms of rule-utilitarianism. In this reply, I attempt to dispel both problems.
Methylation of the oxytocin receptor gene mediates the effect of adversity on negative schemas and depression
Authors: Simons Ronald L. , Lei Man Kit , Beach Steven R. H. , Cutrona Carolyn E. , Philibert Robert A.
Published: June 2016

Building upon various lines of research, we posited that methylation of the oxytocin receptor gene (OXTR) would mediate the effect of adult adversity on increased commitment to negative schemas and in turn the development of depression. We tested our model using structural equation modeling and longitudinal data from a sample of 100 middle-aged, African American women. The results provided strong support for the model. Analysis of the 12 CpG sites available for the promoter region of theOXTRgene identified four factors. One of these factors was related to the study variables, whereas the others were not. This factor mediated the effect of adult adversity on schemas relating to pessimism and distrust, and these schemas, in turn, mediated the impact ofOXTRmethylation on depression. All indirect effects were statistically significant, and they remained significant after controlling for childhood trauma, age, romantic relationship status, individual differences in cell types, and average level of genome-wide methylation. These finding suggest that epigenetic regulation of the oxytocin system may be a mechanism whereby the negative cognitions central to depression become biologically embedded.
Computation over algebraic structures and a classification of undecidable problems
Authors: GAßNER CHRISTINE
Published: June 2016

We consider a uniform model of computation over algebraic structures resulting from a generalization of the Turing machine and the BSS model of computation. This model allows us to gain more insight into the reasons for unsolvability of algorithmic decision problems from different perspectives. For example, classes of undecidable problems can be introduced in several ways by analogy with the classical arithmetical hierarchy and, for many structures, the different definitions lead to different hierarchies of undecidable problems. Here, we will investigate some classes of a hierarchy that is defined semantically by our deterministic oracle machines and that can be syntactically characterized by formulas whose quantifiers range only over an enumerable set. Starting from machines over algebraic structures endowed with some relations and containing an infinite recursively enumerable sequence of individuals, we will also consider this hierarchy for BSS RAM's over the reals and some undecidable problems defined by algebraic properties of the real numbers.
Splitting and non-splitting in the difference hierarchy
Authors: ARSLANOV MARAT
Published: June 2016

In this paper, we investigate splitting and non-splitting properties in the Ershov difference hierarchy, in which area major contributions have been made by Barry Cooper with his students and colleagues. In the first part of the paper, we give a brief survey of his research in this area and discuss a number of related open questions. In the second part of the paper, we consider a splitting of0′ with some additional properties.
Three-dimensional printing of a complex CHD to plan surgical repair
Authors: Hadeed Khaled , Dulac Yves , Acar Philippe
Published: June 2016

We used three-dimensional printing technology to create an anatomical three-dimensional model of a very rare and complex cyanotic CHD in a newborn, consisting of double-outlet left ventricle, ventricular septal defect, and pulmonary stenosis. This case demonstrates how this new innovative technology allows better understanding of the anatomy in complex CHDs and permits to better plan the surgical repair.
Sewing needle: a rare cause of intra-cardiac foreign body in a 3-year-old child
Authors: Choudhary Sandeep , Pujar Venkateshacharya Suresh , Reddy Chinnaswamy
Published: June 2016

Sewing needles are rare causes of penetrating cardiac injury. Suicidal attempt, accidental penetration, domestic violence, and child abuse are likely causes for such injury.1 Owing to their sharp nature, needles can rapidly migrate through the tissues. Fatalities are due to cardiac tamponade, infection, peripheral embolism, and valve dysfunction.
Does ibuprofen treatment in patent ductus arteriosus alter oxygen free radicals in premature infants?
Authors: Akar Melek , Yildirim Tulin G. , Sandal Gonca , Bozdag Senol , Erdeve Omer , Altug Nahide , Uras Nurdan , Oguz Serife S. , Dilmen Ugur
Published: June 2016

Introduction

Ibuprofen is used widely to close patent ductus arteriosus in preterm infants. The anti-inflammatory activity of ibuprofen may also be partly due to its ability to scavenge reactive oxygen species and reactive nitrogen species. We evaluated the interaction between oxidative status and the medical treatment of patent ductus arteriosus with two forms of ibuprofen.

Materials and methods

This study enrolled newborns of gestational age ⩽32 weeks, birth weight ⩽1500 g, and postnatal age 48–96 hours, who received either intravenous or oral ibuprofen to treat patent ductus arteriosus. Venous blood was sampled before ibuprofen treatment from each patient to determine antioxidant and oxidant concentrations. Secondary samples were collected 24 hours after the end of the treatment. Total oxidant status and total antioxidant capacity were measured using Erel’s method.

Results

This prospective randomised study enrolled 102 preterm infants with patent ductus arteriosus. The patent ductus arteriosus closure rate was significantly higher in the oral ibuprofen group (84.6 versus 62%) after the first course of treatment (p=0.011). No significant difference was found between the pre- and post-treatment total oxidant status and total antioxidant capacity in the groups.

Discussion

Ibuprofen treatment does not change the total oxidant status or total antioxidant capacity. We believe that the effect of ibuprofen treatment in inducing ischaemia overcomes the scavenging effect of ibuprofen.
Taut and click: an unusual left ventricular false tendon
Authors: Hussain Arif , Anderson Robert H. , Dhillon Santokh S.
Published: June 2016

A case of an asymptomatic child presenting with persistent systolic ejection click and found to have an unusual left ventricular false tendon attached to aortic valve that has not been described previously and may be responsible for the click.
Prognostic factors of premature closure of the ductus arteriosus in utero: a systematic literature review
Authors: Ishida Hidekazu , Kawazu Yukiko , Kayatani Futoshi , Inamura Noboru
Published: June 2016

Background

A number of case reports show various outcomes of premature closure of the ductus arteriosus in utero, including persistent pulmonary hypertension of the newborn and fetal or neonatal death; however, no study clarifies the clinical observations that are related to their prognoses. We aimed to clarify the prognostic factors of intrauterine ductal closure by a systematic literature review.

Data sources

We searched PubMed database (1975–2014) to identify case reports and studies on intrauterine closure of the ductus arteriosus, including maternal, fetal, and neonatal clinical information and their prognoses.

Results

We analysed the data of 116 patients from 39 articles. Of these, 12 (10.3%) died after birth or in utero. Fetal or neonatal death was significantly correlated with fetal hydrops (odds ratio=39.6, 95% confidence interval=4.6–47.8) and complete closure of the ductus arteriosus (odds ratio=5.5, 95% confidence interval=1.2–15.1). Persistent pulmonary hypertension was observed in 33 cases (28.4%), and was also correlated with fetal hydrops (odds ratio=4.2, 95% confidence interval=1.3–4.6) and complete closure of the ductus arteriosus (odds ratio=5.5, 95% confidence interval=1.6–6.0). Interestingly, maternal drug administration was not correlated with the risk of death and persistent pulmonary hypertension.

Conclusions

Fetal hydrops and complete ductal closure are significant risk factors for both death and persistent pulmonary hypertension. Cardiac or neurological prognoses could be favourable if the patients overcome right heart failure during the perinatal period.
Left thoracic sympathectomy in a premature infant with long QT syndrome and heart failure
Authors: Surendran Sushitha , Kumar Thittamaranahalli K. S. , Knott-Craig Christopher J.
Published: June 2016

Left thoracic sympathectomy has been shown to be an effective treatment for adults with long QT syndrome who are refractory to medical therapy. We report the successful use of left thoracic sympathectomy for the management of a 10-week-old premature baby with long QT syndrome and heart failure from a large ventricular septal defect and patent ductus arteriosus.
Missing LINQ: extrusion of a new-generation implantable loop recorder in a child
Authors: Chaouki Ahmad S. , Czosek Richard J. , Spar David S.
Published: June 2016

Cardiac rhythm monitoring has been facilitated by the use of implantable loop recorders. New models of these devices are 87% smaller than before allowing for easier implantation and use in the paediatric population. Recommendations are for closure with adhesive. We report a device extrusion in a 6-year-old patient. Based on this, our practice has changed to include subcutaneous sutures this complication.
Ventricular septal defect closure in a patient with achondroplasia
Authors: Nakanishi Keisuke , Kawasaki Shiori , Amano Atsushi
Published: June 2016

Achondroplasia with co-morbid CHD is rare, as are reports of surgical treatment for such patients. We present the case of a 13-year-old girl with achondroplasia and ventricular septal defect. Her ventricular septal defect was surgically repaired focussing on the cardiopulmonary bypass flow, healing of the sternum, and her frail neck cartilage. The surgery and recovery were without complications.
The intentional brain—a short history of neuropsychiatry
Authors: Trimble Michael
Published: June 2016

Neuropsychiatry has had different meanings at different times in the history of clinical neuroscience. In this article, the origins of what has become today’s neuropsychiatry are briefly explored, hopefully revealing a number of pioneers of the discipline, some of the names being familiar to many readers, others however being less recognized or even unknown to those who today would wish to carry the moniker of a neuropsychiatrist. It explores the rise of what I refer to as modern or today’s neuropsychiatry, and empathizes a phenomenological approach to clinical understanding, and the fact that neuropsychiatry it is a discipline in its own right and not just a wing of psychiatry or a bridge between neurology and psychiatry.
Mechanism of action of suvorexant
Authors: Stahl Stephen M.
Published: June 2016

Suovrexant is a novel hypnotic and is the only agent clinically available that works by blocking orexin-ergic mechanisms.
Parsing and Working Memory in Bilingual Sentence Processing
Authors: CUNNINGS IAN
Published: June 2016

A growing body of research has investigated bilingual sentence processing. How to account for differences in native (L1) and non-native (L2) processing is controversial. Some explain L1/L2 differences in terms of different parsing mechanisms, and the hypothesis that L2 learners adopt ‘shallow’ parsing has received considerable attention. Others assume L1/L2 processing is similar, and explain L1/L2 differences in terms of capacity-based limitations being exceeded during L2 processing. More generally, the role that working memory plays in language acquisition and processing has garnered increasing interest. Based on research investigating L2 sentence processing, I claim that a primary source of L1/L2 differences lies in the ability to retrieve information constructed during sentence processing from memory. In contrast to describing L1/L2 differences in terms of shallow parsing or capacity limitations, I argue that L2 speakers are more susceptible to retrieval interference when successful comprehension requires access to information from memory.
Psychiatry trainees’ views and educational needs regarding the care of patients with a life-limiting illness
Authors: Forster Benjamin C. , Proskurin Helen , Kelly Brian , Lovell Melanie R. , Ilchef Ralf , Clayton Josephine M.
Published: June 2016

Objective:

People with a life-limiting physical illness experience high rates of significant psychological and psychiatric morbidity. Nevertheless, psychiatrists often report feeling ill-equipped to respond to the psychiatric needs of this population. Our aim was to explore psychiatry trainees’ views and educational needs regarding the care of patients with a life-limiting physical illness.

Method:

Using semistructured interviews, participants’ opinions were sought on the role of psychiatrists in the care of patients with a life-limiting illness and their caregivers, the challenges faced within the role, and the educational needs involved in providing care for these patients. Interviews were audiotaped, fully transcribed, and then subjected to thematic analysis.

Results:

A total of 17 psychiatry trainees were recruited through two large psychiatry training networks in New South Wales, Australia. There were contrasting views on the role of psychiatry in life-limiting illness. Some reported that a humanistic, supportive approach including elements of psychotherapy was helpful, even in the absence of a recognizable mental disorder. Those who reported a more biological and clinical stance (with a reliance on pharmacotherapy) tended to have a nihilistic view of psychiatric intervention in this setting. Trainees generally felt ill-prepared to talk to dying patients and felt there was an educational “famine” in this area of psychiatry. They expressed a desire for more training and thought that increased mentorship and case-based learning, including input from palliative care clinicians, would be most helpful.

Significance of Results:

Participants generally feel unprepared to care for patients with a life-limiting physical illness and have contrasting views on the role of psychiatry in this setting. Targeted education is required for psychiatry trainees in order to equip them to care for these patients.
Understanding the Impact of Electoral Systems on Women's Representation
Authors: Thames Frank C.
Published: June 2016

The study of electoral systems is a key area of research within political science. In part, the attention paid to electoral systems reflects their importance to democratic political systems. Electoral systems define “what constitutes” a vote, establish “a rule for how votes are totaled,” and create a mechanism for “translating vote share into seat allocations” for representative institutions (Bawn 1993, 966). These roles mean that electoral systems impact not only how interests are represented, but also how accountability is structured.
CHARACTER AND OBJECT
Authors: AVIGAD JEREMY , MORRIS REBECCA
Published: June 2016

In 1837, Dirichlet proved that there are infinitely many primes in any arithmetic progression in which the terms do not all share a common factor. Modern presentations of the proof are explicitly of higher-order, in that they involve quantifying over and summing overDirichlet characters, which are certain types of functions. The notion of a character is only implicit in Dirichlet’s original proof, and the subsequent history shows a very gradual transition to the modern mode of presentation.

In this essay, we study the history of Dirichlet’s theorem with an eye towards understanding the methodological pressures that influenced some of the ontological shifts that occurred in nineteenth century mathematics. In particular, we use the history to understand some of the reasons that functions are treated as ordinary objects in contemporary mathematics, as well as some of the reasons one might want to resist such treatment.
Arithmetical Difficulties and Low Arithmetic Achievement: Analysis of the Underlying Cognitive Functioning
Authors: Iglesias-Sarmiento Valentín , Deaño Manuel
Published: June 2016

This study analyzed the cognitive functioning underlying arithmetical difficulties and explored the predictors of arithmetic achievement in the last three grades of Spanish Primary Education. For this purpose, a group of 165 students was selected and divided into three groups of arithmetic competence: Mathematical Learning Disability group (MLD,n =27), Low Achieving group (LA,n =39), and Typical Achieving group (TA,n =99). Students were assessed in domain-general abilities (working memory and PASS cognitive processes), and numerical competence (counting and number processing) during the last two months of the academic year. Performance of children from the MLD group was significantly poorer than that of the LA group in writing dictated Arabic numbers (d= –0.88), reading written verbal numbers (d= –0.84), transcoding written verbal numbers to Arabic numbers (–0.75) and comprehension of place value (d= –0.69), as well as in simultaneous (d= –0.62) and successive (d= –0.59) coding. In addition, a specific developmental sequence was observed in both groups, the implications of which are discussed. Hierarchical regression analysis revealed simultaneous coding (β = .47,t(155) = 6.18,p< .001) and number processing (β = .23,t(155) = 3.07,p< .01) as specific predictors of arithmetical performance.
Are Entrepreneurial Intentions Self-Regulated? Self-Consciousness, Core Self-Evaluations and Entrepreneurial Intentions of Higher Education Students
Authors: Auzoult Laurent , Lheureux Florent , Abdellaoui Sid
Published: June 2016

The main aim of this study is to demonstrate that private self-consciousness (SC) and core self-evaluations (CSEs) influence their formation, via the perceived feasibility and desirability of entrepreneurship or in interaction with it. Two hundred and sixteen students, from a university, an engineering college and a management school, participated in a survey questionnaire which measured these variables as well as controlled factors (e.g. entrepreneurship education, presence of entrepreneurs in their close social network). The results confirm that CSEs have a positive effect on feasibility and desirability (p < .001) which mediate their effect on intention (p < .007). They also show that private SC has a positive direct effect on intention (p < .001). Additionally, the positive interaction effects of desirability and feasibility and public SC and feasibility on intention are highlighted (p < .05). Unexpectedly, none of the hypothesized moderation effects of private SC were corroborated. The convergence of these results with prior research, the limitations of the study and practical implications are discussed.
Validation of the French Version of the Experiences in Close Relationships– Revised (ECR-R) Adult Romantic Attachment Questionnaire
Authors: Favez Nicolas , Tissot Hervé , Ghisletta Paolo , Golay Philippe , Cairo Notari Sarah
Published: June 2016

Abstract. This study aimed to validate the French version of the Experiences in Close Relationships–Revised (ECR-R) adult attachment questionnaire by investigating its internal structure and construct validity. The sample (N = 600) consisted of an equal number of male and female participants aged 25–45 years. Variables linked to adult romantic attachment (marital satisfaction, sexual satisfaction and fears associated with sexual activities, and self-esteem) were assessed using a set of questionnaires. The reliability of the two attachment dimensions (viz., avoidance and anxiety) was satisfactory. Confirmatory factor analyses revealed that the original two-factor model explained the data collected with the French ECR-R most satisfactorily. The assessment of measurement invariance showed that the structure is the same across the original U. S. sample and our sample, across men and women, and across single individuals and those in a couple relationship. Our evaluation of construct validity showed that the higher avoidance and anxiety, the lower self-esteem and sexual satisfaction and the higher the fears associated with sexuality. These results are theoretically coherent and consistent with those of previous studies of the English version of the scale. We conclude that the French version is valid.
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
Authors: Tsukumo Yoshinori , Alain Tommy , Fonseca Bruno D. , Nadon Robert , Sonenberg Nahum
Published: June 2016

Targeting mTORC1 is a highly promising strategy in cancer therapy. Suppression of mTORC1 activity leads to rapid dephosphorylation of eIF4E-binding proteins (4E-BP1–3) and subsequent inhibition of mRNA translation. However, how the different 4E-BPs affect translation during prolonged use of mTOR inhibitors is not known. Here we show that the expression of 4E-BP3, but not that of 4E-BP1 or 4E-BP2, is transcriptionally induced during prolonged mTORC1 inhibition in vitro and in vivo. Mechanistically, our data reveal that 4E-BP3 expression is controlled by the transcription factor TFE3 through a cis-regulatory element in the EIF4EBP3 gene promoter. CRISPR/Cas9-mediated EIF4EBP3 gene disruption in human cancer cells mitigated the inhibition of translation and proliferation caused by prolonged treatment with mTOR inhibitors. Our findings show that 4E-BP3 is an important effector of mTORC1 and a robust predictive biomarker of therapeutic response to prolonged treatment with mTOR-targeting drugs in cancer.
Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
Authors: Richman Tara R. , Spåhr Henrik , Ermer Judith A. , Davies Stefan M. K. , Viola Helena M. , Bates Kristyn A. , Papadimitriou John , Hool Livia C. , Rodger Jennifer , Larsson Nils-Göran , Rackham Oliver , Filipovska Aleksandra
Published: June 2016

The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1 is not required for embryonic survival, although the mutant mice have substantially reduced COXI protein, causing an isolated complex IV deficiency. We show that TACO1 specifically binds the mt-Co1 mRNA and is required for translation of COXI through its association with the mitochondrial ribosome. We determined the atomic structure of TACO1, revealing three domains in the shape of a hook with a tunnel between domains 1 and 3. Mutations in the positively charged domain 1 reduce RNA binding by TACO1. The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease.