bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of Reliable Body Channel Communication Transceiver with Spread Spectrum Clock Generator and PNR Generator
Authors: S Vijayalakshmi , V Nagarajan
Published: September 2018

In this work, the communication of a channel in the human body has a characteristic (time-domain) which can be measured at various distances in transmission and various frequencies of a signal by the printed circuit board-an analog frontend board (PCB-AFE) support. Besides, for the wideband signal of Body Channel Communication (BCC), a human body skin acts within a range of 1 Mb/s to 40 Mb/s as the transmission medium. This communication is more stable and attenuating low power while comparing with all another transmission medium in wireless. Moreover, due to the motion of a human body, this communication doesn't get affected. Though, the body antenna gives effects in the communication of a channel of the human body by occurs some interference. The Manchester data acts as encoder and decoder in transmitter and receiver parts respectively, in an AFE-PCB the Manchester encoder data is amplified after receiving the data from end to end channel of a human body. The data quality is improved by 7X sampler in clock data recovery (CDR) circuit. Therefore, the proposed design of reliable BCC Transceiver with SSCG and PNR Generator is processed in XilinxISE14.5, ModelSim Simulator 6.5a (Quartus II 8.1), and Micro wind software tools. It is also implemented in a XilinxXC9572XL kit. The power consumption and delay is reduced up to 90%, speed is increased up to 50% and leakage current is reduced up to 80% in the transmitter part.
A Secure Communication through Quantum Key Distribution Protocols
Authors: Teja Penumantra Satya Sai , P Mounika Lakshmi , K Vinay Kumar
Published: September 2018

Quantum cryptography is a new method of communication offering the security of the inviolability by using Law of Nature.Quantum Cryptography uses different secure communication by applying the phenomena of quantum physics. Unlike traditional classical cryptography, which uses mathematical techniques to restrict eavesdroppers, quantum cryptography is focused on the properties of physics of light for information. Quantum cryptography depends only on the validity of quantum theory, i.e., it is guarantied directly by the laws of physics. This is a different from any classical cryptographic techniques. This paper summarizes the current state of quantum cryptography and provides potential extensions of its feasibility as a mechanism for securing existing communication systems.
Estudio físico-químicos de los huevos de Iguana iguana Linnaeus, 1758
Authors: Guzmán-Guzmán Margarita , Zuñiga Herly , Moreno S John Alexander , GRANADOS M Jairo E
Published: October 2018

Caracterización físico-químicamente de huevos de Iguana iguana. Las pruebas físicas se realizaron por métodos de Espectrofotocolorimetría, calibrador, cinta métrica, micrómetro, flexómetro y flotación y las pruebas químicas acorde a los lineamientos exigidos por la A.O.A.C. Los resultados obtenidos mostraron con respecto a las características físicas: En promedio, un peso de 14,78 (g); diámetro longitudinal 39,70 mm (±0,49), diámetro transversal 26,41mm (±0,6), largo perimetral 11,55 cm (±0,2), ancho perimetral 9,07 cm (± 0,2), entre otras caractericticas evaluadas. Respecto a la composición química, en cáscara 51,23% (±3,02) Calcio Inorgánico; 20,17% (±1,56) Fósforo Inorgánico; en albumen 51,47% (±1,05) de proteína bruta, un 17,02% (±1,33) de grasa cruda y en albumen compacto un peso de 3,83 g (±0,21). Mediante regresiones múltiples se determinó que el peso depende del porcentaje de cáscara y del albumen compacto en un 87%. La gravedad específica depende no solo del largo perimetral sino también del porcentaje de cáscara y del grosor de ésta en la zona ecuatorial en un 86,3%. El porcentaje de cáscara, del peso, gravedad específica y grosor en la zona ecuatorial en 88,3%. La caracterización cromática determinó su color entre amarillo medio y blanco amarillento.
Aportes a la distribución del género Micrurus (Serpentes: Elapidae) en el Departamento del Chocó, Colombia
Authors: Pitalua-L Yousmang , Rengifo-M Jhon Tailor , Rivas- A Lucellis
Published: October 2018

Se estudió la distribución potencial de las serpientes de coral, género Micrurus (Serpentes: Elapidae), para el bosque pluvial tropical en el departamento del Chocó; por medio de una revisión detallada de colecciones en la bases de datos del SIB-Colombia (Sistema de Información de Biodiversidad-Colombia) para la distribución potencial se utilizó el programa Maxen, generando un mapa para cada especie. La revisión arrojo un total de 145 individuos en colecciones de las siete especies reportadas para el Chocó, depositados en ocho colecciones científicas del SIB; las especies M. dumerilli y M. ancorali, fueron las que más registro presentaron en las colecciones consultadas; M. dumerilli es una de las especies de mayor distribución pues permanece en las selvas tropicales colonizando distintos microhábitats, seguida de M. ancoralis que se distribuye en el departamento del Chocó, Cauca, Risaralda, Nariño y Valle del Cauca; por otro lado, en el análisis de especies endémicas se encontró que M. spurelli es una especie que solo se distribuye en el departamento del Chocó. Las subregiones del sur y del centro albergan la mayor riqueza de este género, obteniendo así el 100% de las especies que son reportadas para el departamento del Chocó.
Hallazgos anatomopatologicos en un bovino infectado con tuberculosis en Vicosa, Brasil
Authors: Reyes B Bernardo , Cardona Á José , Montes V Donicer , Vargas V Marlene
Published: October 2018

Se reportó un caso de tuberculosis bovina en una hembra Holstein de aproximadamente 350kg de peso, la cual fue necropsiada por el servicio de patología animal de la facultad de Medicina Veterinaria y Zootecnia de la Universidad de Viçosa, Brasil. El propietario reporta emaciación progresiva, debido al pésimo estado de salud se decidió sacrificar el animal y posteriormente se trasladó al área de patología donde fue realizada la necropsia. Se evidencio pelaje hirsuto, mucosas pálidas y marcada caquexia a la inspección externa del cadáver, los hallazgos anatomopatológicas en la necropsia revelaron importantes lesiones como: áreas caseificadas nodulares en músculos en la región intercostal, pleura, pulmón, hígado y ganglios linfáticos pre-escapulares. El diagnóstico definitivo del cadáver fue tuberculosis bovina.
Morbimortalidade Hospitalar por Epilepsia: análise de dados oficiais
Authors: Lima Leandro Januário de , Brito Raquel Carlos de , Farias Maria do Carmo Andrade Duarte de
Published: October 2018

O objetivo deste trabalho foi descrever o perfil clínico-epidemiológico da morbimortalidade hospitalar da Epilepsia nas macrorregiões brasileiras. Trata-se de um estudo descritivo, de cunho quantitativo, epidemiológico retrospectivo, de série temporal, do tipo Ecológico. O objeto de estudo foram os dados sobre morbimortalidade hospitalar entre os anos de 2010 e 2014, disponíveis nos bancos de dados do Ministério da Saúde. Os dados apresentaram uma pequena redução nos internamentos, que passaram de 47819, no ano de 2010, para 46493 ao final da série, em 2014. A taxa de mortalidade hospitalar brasileira variou de 2,26 para 1,97 no período estudado. Em cinco anos, mais de 130 mil hospitalizações no país ocorreram em leitos do setor público, com quase 110 mil no setor privado. O pico dos casos encontra-se nos pequenos infantes, entre um e quatro anos de idade. O padrão de redução dos casos na adolescência, com nova elevação da prevalência entre a terceira e quinta década de vida se repete nas cinco macrorregiões do país. Conclui-se que o estudo das características clínico-epidemiológicas da morbimortalidade hospitalar da Epilepsia nas macrorregiões brasileiras auxilia na compreensão das desigualdades regionais e na proposição de novas estratégias de fomento do sistema único de saúde.
CORRELATION OF DENGUE VIRUS SEROTYPE AND DVI SEVERITY IN ADULT PATIENTS
Authors: Andriani Suci , Aryati Aryati , Hadi Usman
Published: September 2018

The clinical manifestation of dengue virus infection is often not clear, varies widely from mild to severe. Exposure of dengue virus which serotype is different from a previous infection is a risk factor for the severe manifestation of dengue virus infection. Dengue hemorrhagic fever is classified into four degrees of severity based on clinical manifestations and laboratory results. Real-time RT-PCR Dengue can detect dengue virus serotype in early dengue virus infection. The aimed of this study was to prove the correlation between dengue virus serotype and degree of severity in adult patients. This study was a cross-sectional observational design done in February until July 2016. Subjects consisted of 100 dengue virus infection patients. Serum of the patients was examined using Real-time RT-PCR Dengue (Simplexaâ„¢ Dengue). It was shown that from 46 patients with DENV-3 serotype was 63%, DENV-2 serotype 17.4%, DENV-1 serotypes 17.4% and mixed infection of DENV-1 and DENV-3 serotype 2.2%. There was not any DENV-4 serotype. Dengue Hemorrhagic Fever (DHF) stage I was 47.8%, DHF stage II was 30.4%, DHF stage III was 10.9% and Dengue Fever was 10.9%. There was not any DHF stage IV. There was not enough evidence that DENV-3 correlated with the degree of severity (p= 0.510). Based on this research, DENV-3 serotype was the dominant serotype prevalent at the Dr. Soetomo Hospital. There was no correlation between viral dengue serotype and severity in dengue adult patients in this study.
IMMUNOLOGY OF MULTIPLE SCLEROSIS
Authors: Bahrun Uleng , Wijaya Chelvi
Published: September 2018

Multiple Sclerosis (MS) is an autoimmune disease that causes myelin destruction in the Central Nervous System (CNS). Characteristics of this disease are perivascular infiltration by inflammatory cells, demyelination and loss of axons, accompanied by multiple plaque formation in the brain and spinal cord. According to the National Multiple Sclerosis Society, 400,000 people suffer from MS in the United States and about 2.5 million people worldwide. The disease is usually diagnosed in patients aged 20-45 years and more often found in females than males with a ratio of 2: 1. Nevertheless, the etiology of MS is still unknown, but it is suspected that genetic and environmental factors may induce a response to central nervous system autoantigen, such as Epstein-Barr Virus (EBV) infection. It then causes edema, demyelination, axon destruction and loss of oligodendrosites, resulting in neurological deficits, plaque formation, scarring and reduced brain volume. Multiple sclerosis symptoms and signs actually vary greatly depending on the location of the lesions and the course of the various diseases. Multiple sclerosis, moreover, can be divided into four clinical categories, namely Clinically Isolated Syndrome (CIS), Relapsing Remitting Multiple Sclerosis (RRMS), Secondary Progressive Multiple Sclerosis (SPMS) and Primary Progressive Multiple Sclerosis (PPMS). Diagnosis of Multiple sclerosis is established based on clinical symptoms and supporting investigations, such as MRI, CSF and neurological examination. In CSF examination, oligoclonal bands are found in over 90% of patients, considered as one of the laboratory criteria supporting the diagnosis of MS. There are four kinds of drugs that have been approved by the FDA as disease modifying therapy for the initial treatment of MS patients, namely interferon beta-1a, subcutaneous (SC) interferon beta-1a, interferon beta-1b and glatiramer acetate  In conclusion, life expectancy in MS patients is only slightly reduced and survival is related to the disability occurred.
The Development of an Ingenious Circuit Based on Chemo-Edutainment Learning
Authors: Sari Sri Adelila , Rezeki Yuni Sri
Published: October 2018

One way to solve the problem of chemistry learning is that teachers are expected to have methods, models of teaching and learning, as well as learning media that can choose according to the subject concepts to be conveyed. This research was aimed to develop a learning media called as ingenious circuit, and to describe the activity also users’ feedback on the developed media. The type of research was research and development (R & D). While the used design of development was ADDIE (Analysis, Design, Development, Implementation, and Evaluation) using qualitative methods. The research was conducted in senior high school named SMAN 1 Krueng Barona Jaya in class XI MIA 2 with a number of 20 students. The instruments used to collect the data were a sheet for media validation, questionnaires to measure the response, and the observation sheet to measure student activity during use the developed media. After the ingenious circuit was developed with the phase of ADDIE, the validation results showed that a viable ingenious circuit up to 100 percent on aspects of the format. While the visual aspect, the feasibility of achieving 90.62 percent. In addition, the circuit was also tested for eligibility based on the aspect of clarity in the presentation of the question and the results was found to reach 100 percent, as well as on aspects of functioning or quality of 87.5 percent. This study also found that the response of the students after they used the media, including the highly positive, as much as 90.00 percent. As well as with teachers, the responses were in very good condition, which reached 89.29 percent. In addition, the student activity test results when they use this developed circuit was considered very active, with an average percentage score of 80.57. Based on the overall results of the study, it can be concluded that a series of ingenious circuit could be developed with ADDIE model and feasible to implement in the learning process of colloids. In addition, the responses of students and teachers those who used the circuit were also very positive, especially the students more active in the learning process of colloids
Takotsubo cardiomyopathy: queries of the current era
Authors: Cusmà-Piccione Maurizio , Longobardo Luca , Oteri Alessandra , Manganaro Roberta , Di Bella Gianluca , Carerj Scipione , Khandheria Bijoy K. , Zito Concetta
Published: October 2018

Takotsubo cardiomyopathy (TTS), also known as left ventricular apical ballooning syndrome, is an acute, usually reversible heart failure syndrome that most often affects postmenopausal women experiencing an emotionally stressful event. It is characterized by sudden left ventricular dysfunction and wall motion abnormalities involving the apical and mid segments. TTS has been increasingly recognized in recent years, and more and more information about the pathophysiology, diagnosis, and treatment of these patients has been reported. However, much is still unknown. TTS has a wide variety of clinical subtypes and has been described in several clinical contexts. Moreover, TTS simulates ST-segment elevation myocardial infarction and acute myocarditis, and it can be difficult to obtain a certain diagnosis. As a result, clinical decisions are challenging, and many patients currently receive an inappropriate management strategy. The aim of this review is to critically analyze the evidence about this disease reported in the literature, with particular focus on the pathophysiological processes, the diagnostic elements that can help the clinician differentiate it from other diseases, and the best management of these patients.
Age Estimationof Pawon Manwith Teeth Identification Using Johanson Method Through Cbct 3d Radiograph
Authors: Yondri Lutfi -
Published: September 2018

Abstrac. Pawon man is prehistoric human who lived in Pawon cave. The skeletons founded in  the cave consist of rest of brittle bones and teeth which still attached to alveolar bone even though it had immersed inside the soils on thousands years ago. Then, the teeth are used as primary identification in forensic odontology research. This research aimed is to compare age estimation of Pawon man with Johanson method. Previously, the age estimation was made only based on visual observation of posterior molars attrition by Brothwell method. This research is a descriptive studied using purposive sampling. The samples are 21 teeth that intact and attach to the alveolar bone without any fracture line. The measurement of age estimation with Johanson method using Ez-Implant software, it’s non-invasive age measurement by Cone Beam Computed Tomography 3D radiograph. The results showed that the age of first Pawon man is 32-33.92 years old, third Pawon man is 32.935-36.275 years old, fourth Pawon man is 34.42 years old, and fifth Pawon man is 27.36-31.35 years old. Nonetheless, the second Pawon man is not included in sampling criteria. The measurement using Johanson method through  CBCT.  Abstrak. Manusia Pawon adalah manusia prasejarah yang pernah hidup di Gua pawon pada masa lalu. Kerangka didirikan terdiri dari sisa tulang rapuh dan gigi yang masih menempel pada tulang alveolar meskipun telah terdeposisi di dalam tanah dari ribuan tahun yang lalu. Gigi merupakan digunakan sebagai identifikasi utama dalam penelitian odontologi forensik. Penelitian ini bertujuan untuk membandingkan estimasi usia manusia Pawon menggunakan metode Johanson. Sebelumnya, estimasi usia baru dibuat hanya berdasarkan pengamatan visual dari atrisi molar posterior menggunakan metode Brothwell. Penelitian ini merupakan penelitian deskriptif menggunakan purposive sampling. Sampel adalah 21 gigi yang utuh dan menempel pada tulang alveolar tanpa garis fraktur. Pengukuran estimasi umur bersifat non-invasif menggunakan hasil radiografi Cone Beam Computed Tomography 3D dan dianalisis melalui metode Johanson menggunakan software Ez-Implan. pengukuran Hasil penelitian menunjukkan bahwa usia manusia Pawon pertama adalah 32-33,92 tahun, Manusia Pawon ketiga adalah berusia 32,935-36,275 tahun, Manusia Pawon keempat berusia 34,42 tahun, dan Manusia Pawon kelima berusia 27,36-31,35 tahun. Manusia Pawon kedua tidak diukur karena tidak termasuk dalam kriteria sampling. Dapat dismpulkan bahwa pengukuran menggunakan metode Johanson melalui CBCT 3D lebih spesifik dan detail dalam menghasilkan estimasi umur dibandingkan dengan metode Brothwell.
New approaches to correction of hyperammonemia in patients with non-alcohol steatohepatitis – liquidators of consequences of the accident at Chernobyl APP and personnel of the Federal Fire Service of the EMERCOM of Russia
Authors: Batskov S. S. , Inzhevatkin D. I.
Published: September 2018

Relevance.The relevance of this study is determined by the need to correct hyperammonemia in patients with diffuse liver diseases at the pre-cirrhotic stage, since elevated levels of ammonia in the serum have toxic effects on the central nervous system, with the development of hepatic encephalopathy.

Intention.To evaluate current medication options for correction of hyperammonemia in chronic non-alcoholic steatohepatitis in the liquidators of the consequences of the accident at the Chernobyl nuclear power plant (NPP) and personnel of the Federal Fire Service (FFS) of the Emercom of Russia.

Methodology.34 liquidators of consequences of the accident at the Chernobyl NPP nuclear power plant and 38 employees of the FFS of the Emercom of Russia underwent clinical and laboratory studies, including ammonia levels in blood plasma by enzyme method, evaluation of microbiota disorders, and liver fibrosis grade before and after treatment with L-ornithine-Laspartate (LOLA), as well as a combination of lactulose and a course of rifaximin.

Results and Discussion.After correction of hyperammonemia in patients with chronic non-alcoholic steatohepatitis – the liquidators of the consequences of the Chernobyl accident and personnel of the FFS of the Emercom of Russia, there was a decrease in the clinical manifestations of asthenovegetative and dyspeptic syndromes; the incidence of cytolytic and cholestatic syndromes. Besides, intestinal microbiota disorder decreased, as well as fibrotic changes in the liver, and the severity of intrahepatic hemodynamics disorder. In previous studies, the correction of hyperammonemia was mainly carried out with LOLA or lactulose.

Conclusion.All liquidators of the consequences of the Chernobyl accident and employees of the FFS of the Emercom of Russia with chronic non-alcoholic steatohepatitis and hyperammonemia should undergo its correction. LOLA is most effective in case of non-cirrhotic portal hypertension and the development of minimal hepatic encephalopathy, and a combination of rifaximin and lactulose is most effective if the intestinal dysbiosis prevails.
Pelvic angiography and embolization as a method of diagnosis and surgical haemostasis in victims with pelvic injuries
Authors: Kazhanov I. V. , Mikityuk S. I. , Kolchanov E. A. , Manukovskiy V. A.
Published: September 2018

Relevance.Pelvic injuries are the most dangerous and complex in treatment injuries of the skeletal system with mortality rates up to 15–18 % and up to 65 % in hemodynamically unstable victims. Continuing massive pelvic hemorrhage is the main cause of unstable hemodynamics in victims with severe pelvic injuries and requires surgical hemostasis, including endovascular embolization.

Intention.To evaluate the effectiveness of diagnostic pelvic angiography (AG) and embolization as a method of surgical hemostasis in patients with polytrauma and pelvic injuries.

Method.We analyzed the results of treatment of 14 patients with polytrauma and mechanical injuries of the pelvic ring, who underwent pelvic angiography (AG) at the level I trauma center (St. Petersburg, 2013–2017). The effectiveness of surgical (endovascular) hemostasis was assessed based on the systolic blood pressure (SBP) over time, the basic composition of arterial blood (pH and lactate, buffer base deficiency (BE)), duration and volume of hemotransfusions.

Result and their analysis. There are statistically significant differences between the average volumes of replacement hemotransfusion before and after AG with endovascular embolization of damaged arteries, as well as between the mean lactate levels and the deficit of BE in the arterial blood. The overall mortality rate was 6 (42.8 %) cases. Three victims (21.4 %) died during the first 24 hours and 3 (21.4 %) – during the first two weeks after the trauma. The causes of death were irreversible blood loss – 3 (21.4 %), generalized infection – 1 (7.1 %), multi-organ failure – 2 (14.2 %). The average length of treatment was (52.5 ± 24.9) days.

Conclusion.Angiography gives little information in patients with low SBP, so direct surgical hemostasis like pelvic packing is preferrable and may be used as a “bridge” to AG with temporary stabilization of hemodynamics.
The close consequences of the prolonged famine in children and adolescents
Authors: Кhoroshinina L. P. , Churilov L. P. , Shabrov A. V. , Gonchar N. О.
Published: September 2018

Relevance.The relevance of the topic is due to the increase in the number of starving children in the modern world and the increase in financial costs associated with the consequences of long-term starvation of children and adolescents.

Intention.To systematize ideas about the consequences of starvation in children and adolescents via reintroducing the materials on the Leningrad siege into scientific circulation.

Method.The available domestic and foreign sources of scientific literature and data of archival documents were studied.

Result and their analysis. Information on the immediate consequences of prolonged famine in children and adolescents is presented. The results of scientific works of scientists, studying the consequences of prolonged starvation of Russian children in the early XX century, during the years of Leningrad siege and after the end of the Great Patriotic War.  Long-term starvation of children and adolescents causes profound changes in various organs and systems, having different effects on the physical status of children of different sex and age, largely predetermines the poor health in the subsequent years of life.

Conclusion. The presented information is important for science and practice, since the occurrence of emergency situations in the modern world can be accompanied by prolonged famine or malnutrition of children.
Emergency response of medical force during the international exercise of the rescue services of Russia, Norway, Finland and Sweden – Barents Rescue-2017
Authors: Gudz Yu. V. , Aleksanin S. S. , Rybnikov V. Yu. , Bashinskii O. A.
Published: September 2018

Relevance. The probability of emergency situations in the Barents region determines the need of improvement of forces and means of rendering first and emergency medical care to victims. In September 2017 the large-scale international exercise of rescue services of Russia, Norway, Sweden, and Finland under the code name “Barents-Rescue 2017” was carried out in the Republic of Karelia. The exercise worked oved rendering first-aid and emergency medical care to victims of emergency situations.

Intention. To summarize experience in preparation, rendering and result assessment of first-aid and emergency medical care to victims of emergency situations in the framework of the international exercises.

Methods. Medical document analysis (hospital records, medical triage records, expert assessment records), statistical analysis of groups using Student’s t-test. The exercise involved 76 victims with injuries of various severity levels, among them 30 were of minor severity, 19 were of medium severity and 27 were of heavy severity. They received first-aid and emergency medical care by 42 rescuers and 67 health workers (doctors, paramedics, nurses) of rescue services of Russia, Norway, Sweden, and Finland. Results assessment was made on the basis of the developed hospital records, medical triage records and expert assessment records and also statistical analysis methods.

Result and their analysis. The average expert assessment of a first-aid rendered by rescuers was sufficiently high and was equal to 4.6 ± 0.1 on a 5-score rating system, where 5 points means providing full assistance in accordance with the established standards of its provision. A qualitative medical triage was provided competently, the ordering of evacuation was right, life-threatening damages and injuries were properly defined. At the stage of medical evacuation all the victims were provided with full assistance, there were no divergence of diagnoses, some differences from final diagnose were permissible at the stage of medical evacuation and had no effect on victim’s condition. In addition, a part of the victims in the hospital had medical cards, where was information about the diagnoses and the measures taken. These medical documents were also analyzed in terms of the timeliness and quality of the provision of specialized medical care to injured people in the hospital.

Conclusion. The results of expert assessment during the international exercise of rescue services of Barents Rescue 2017 showed that the quality of first-aid, medical triage and emergency medical care during the evacuation and also in the hospital is high enough, but there were some remarks too. Suggestions and comments were addressed to the Exercise organizing committee to improve the engagement during first-aid and medical care to victim of the emergency and they were included in the final report on the exercise.
Assessing effectiveness of topical hemostatic chitosan-based agents in experiments
Authors: Denisov A. V. , Nosov A. M. , Telitskii S. Yu. , Demchenko K. N.
Published: September 2018

Relevance.Persistent profuse external hemorrhage is known to be one of the main causes of death in combat casualties.

Intention.To evaluate experimentally the effectiveness of new chitosan-based topical hemostatic agents (THA) in various models of profuse external arterial hemorrhage.

Method.New hemostatic chitosan-based agents of Hemohit type in various pharmaceutical dosage forms (Hemohit powder, 20 g per package and Hemohit-applicator [fine chitosan powder Hemohit-A or chitosan granules Hemohit-AG 6 g in the syringe-applicator]) were assessed for effectiveness in the model of profuse external arterial hemorrhage (bevelled laceration of the femoral artery) in 10 large laboratory animals (pigs). Evaluation of the THA effectiveness was performed according to the following parameters: primary hemostasis – stopping of bleeding immediately after application of the 1st THA package and application of a pressure bandage; secondary haemostasis – stopping bleeding immediately after applying the 2nd THA package and applying a pressure bandage, if the 1st THA package is ineffective; final hemostasis – no bleeding within 3 hours of follow-up; absence / resumption of bleeding after the march test; total amount of blood loss during the experiment; survival.

Result and their analysis. It was experimentally found that in the case of external profuse arterial hemorrhage the powder and the syringe-applicator provided permanent hemostasis and 100 % animal survival. In two cases out of four, a second package of Hemohit powder was required for the final stop of bleeding. The bleeding stopped due to the formation of an edge thrombus in the area of the vascular wall defect.

Conclusion.Hemohit THA can effectively stop arterial bleeding. The effectiveness of applicator with local hemostats can be assessed in the proposed experimental model with a deep narrow wound canal and femoral artery damage.
Disturbances in the functioning of the immune system as a consequence of a prolonged expоsure to low dosages of depleted uranium
Authors: Stosman K. I. , Sivak K. V. , Savateeva-Ljubimova T. N.
Published: September 2018

Relevance. Depleted uranium (DU) is actively used in many industries. The problems of the safety of personnel employed at industrial facilities of this kind continue to remain relevant. Experimental studies have shown the toxicity of uranium compounds, especially its soluble forms.

Intention.  To identify immunological disorders developing after chronic exposure to low-dose depleted uranium.

Methods. The study involved 30 outbred rats and 60 mice CBA. Uranyl acetate dehydrate was used as a toxicant and administered intragastrically for 120 days. The relative number of T-lymphocytes, apoptotic and necrotic cells, the production of TNF-α, IL-1, -4, -6-β, the level of circulating immune complexes, the phagocytic activity of neutrophils, delayed-type hypersensitivity reactions, and production of immunoglobulins were assessed.

Results and Discussion.  According to the tests on rats, phagocytic-metabolic activity of neutrophils as well as TNF-α production increased, CD4+/CD8+ ratio decreased, and the early stage apoptosis of mononuclear cells was activated after chronic exposure to uranium salts. Most detected changes were dose-dependent. In experiments on mice it was shown that uranyl acetate dehydrate at a dose of 5 mg/kg had no effect on the functional activity of immunocytes, while the index of the delayed-type hypersensitivity reaction and IgG titers increased in animals which were administered DU at a dose of 10 mg/kg.

Conclusion. The results can be used to provide specialized medical care after chronic exposure to depleted uranium.
The neuromorphological correlates of prolonged radiation exposure
Authors: Ushakov I. B. , Fedorov V. P.
Published: September 2018

Relevance.Liquidators of the consequences of radiation accidents have an increase in neuropsychiatric diseases. However, the structural and functional rearrangement of brain neurons under prolonged low radiation exposure remains virtually unexplored, which makes it difficult to assess the pathogenesis of these diseases.

Intention.To study morphological correlates of prolonged low radiation effects on brain neurons in the model of radiobiological experiment.

Method.270 white outbred male rats aged 4 months were exposed to radiation-quanta of 60Co in equal portions in total doses of 10; 20; 50 and 100 cGy with a dose rate of 0.5 Gy/h over 5 days. Age control consisted of animals exposed to false radiation. Animal studies complied with GLP standards. Brain fragments were taken after 1 day, 6, 12, 18 and 24 months after irradiation. After a standard histological treatment, changes in the tinctorial properties of neurons, their morphometric parameters, total protein and nucleic acids were evaluated.

Results and their analysis. At the end of the observation period, the number of normochromic neurons decreased and the number of hyper and hypochromic cells increased, as well as their destructive forms. The neuro-cellular index decreased over time suggesting the death of some neurons, but without a statistically significant decrease in their number per area. In the post-irradiation period there were observed phase changes in the size of the cytoplasm, nucleus and nucleolus of neurons, as well as the content of protein and nucleic acids (RNA in the cytoplasm and nucleoli, DNA in the nuclei), more pronounced in irradiated animals and sometimes different from those observed in age control animals. As a result, a number of neuromorphological parameters in some periods of observation were not consistent with those in control animals, with a certain instability in the structural and functional organization of neurons.

Conclusion.Prolonged low-dose ionizing radiation does not cause significant organic changes in the brain. However, increased radiation exposure or other concomitant adverse factors can be associated with further instability of the structural and functional organization of neurons and serve as a material substrate for a number of deviations in the central nervous system.
Efikasi Agensia Hayati Trichoderma sp. Terhadap Karat Daun (Puccinia arachidis) Pada Kacang Tanah
Authors: Syarief Mochamad , Prahitasari Elvirlya , Wardana Rudi
Published: September 2018

Kacang tanah (Arachis hypogeae) merupakan bahan pangan yang diminati oleh masyarakat. Kontribusi produksi kacang tanah dari Provinsi Jawa Timur terhadap produksi Nasional mengalami penurunan pada tahun 2016. Faktor penyebab rendahnya hasil panen kacang tanah di Indonesia yaitu penyakit karat daun (Puccinia arachidis). Dalam penelitian ini, pengendalian karat daun pada tanaman kacang tanah dengan jamur antagonis Trichoderma sp. Penelitian ini memiliki tujuan untuk mengetahui bagaimana pengaruh agensia hayati Trichoderma sp. terhadap intensitas serangan penyakit karat daun, jumlah polong dan berat basah polong kacang tanah. Penelitian ini dilaksanakan pada bulan Juli 2017 hingga Maret 2018 di Laboratorium Perlindungan Tanaman Politeknik Negeri Jember dan lahan di Desa Antirogo, Kecamatan Sumbersari, Kabupaten Jember. Penelitian ini menggunakan Rancangan Acak Kelompok non faktorial terdiri dari 4 perlakuan di antaranya A0 (Tebukonazol 0,3 ml/l), A1 (Trichoderma sp. 105cfu/ml), A2 (Trichoderma sp. 106cfu/ml), A3 (Trichoderma sp. 107 cfu/ml) dengan 6 ulangan. Uji data menggunakan ANOVA (Analyze of Varians) dan uji lanjut dengan BNT 5%. Hasil dari penelitian adalah bahwa dari 4 perlakuan tersebut tidak berpengaruh nyata terhadap tingkat intensitas serangan karat daun, jumlah polong serta berat polong kacang tanah. Intensitas serangan Puccinia arachidis berkorelasi negatif terhadap jumlah polong dan berat basah polong.
Penggunaan Tiga Ukuran Umbi dan Zat Pengatur Tumbuh (Atonik) Pada Tanaman Sedap Malam (Polianthes tuberosa L.)
Authors: Rahayu Desta , Marveldani FNU , Andini Siti Novridha
Published: September 2018

Tanaman sedap malam diperbanyak menggunakan umbi yang merupakan batang semu yang berubah bentuk dan fungsi sebagai penyimpanan cadangan makanan untuk pertumbuhan dan perkembangan. Penelitian dilaksanakan di lahan Politeknik Negeri Lampung pada bulan Mei 2017 sampai Maret 2018. Penilitian ini menggunakan Rancangan Kelompok Teracak Sempurna dengan dua faktor perlakuan. Faktor pertama terdiri dari diameter ukuran yaitu besar (1,6 - 2 cm), sedang (1,4 - 1,5 cm) dan kecil (1,3 - 1 cm). Faktor kedua terdiri dari perlakuan zat pengatur tumbuh Atonik yaitu 0 (tanpa perlakuan), 1 ml.l-1 dan 3 ml.l-1. Hasil penelitian ini menunjukkan bahwa ukuran umbi besar (1,6 cm - 2 cm) menghasilkan panjang tanaman (38,9 cm), jumlah daun (16,1 helai), lebar daun (1,9 cm) dan jumlah anakan (9,8 tunas) yang tertinggi serta menghasilkan umur tanaman mengeluarkan malai bunga (24,9 MST) dan umur mekar bunga (28,3 MST) yang lebih cepat. Ukuran umbi sedang (1,4 cm - 1,5 cm) dan kecil (1 cm - 1,3 cm) menghasilkan panjang tangkai bunga terpanjang (79,8 cm dan 86,6 cm).
Efektivitas Jenis Asam Amino dan Variasi Konsentrasi Sukrosa terhadap Pertumbuhan Planlet Kentang (Solanum tuberosum L.)
Authors: Maysyaroh Qurrota A'yun , Ermawati Netty
Published: September 2018

Penelitian ini bertujuan untuk mengetahui respon pertumbuhan planlet kentang dengan penambahan asam amino dan variasi konsentrasi sukrosa serta untuk mengetahui jenis asam amino dan konsentrasi sukrosa terbaik untuk pertumbuhan planlet kentang. Penelitian telah dilaksanakan di Laboratorium Biosain Politeknik Negeri Jember pada Agustus 2017 sampai Januari 2018. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial dengan 2 faktor dan 4 ulangan. Faktor pertama adalah jenis Asam amino (A), terdiri atas: Kasein Hidrolisat 100 ppm (A1), Kasein Hidrolisat 200 ppm (A2), Glutamin 100 ppm (A3), Glutamin 200 ppm (A4), Glisin 100 ppm (A5), Glisin 200 ppm (A6).Faktor kedua konsentrasi sukrosa, terdiri atas: 20 g/L (S1), 30 g/L (S2), dan 40 g/L (S3). Hasil penelitian menunjukkan bahwa glutamin 100 ppmmenghasilkan tanaman tertinggi. Perlakuan sukrosa terbaik adalah 30 g/L yang menghasilkan jumlah daun, jumlah ruas, bobot planlet dan tinggi tanaman tertinggi. Interaksi perlakuan terbaik pada glutamin 100 ppm dengan sukrosa 30 g/L yang memberikan bobot planlet dan tinggi optimal.
Aplikasi Jenis Pupuk Organik Padat dan MOL (Mikro Organisme Lokal) Bonggol Pisang Terhadap Produksi Kacang Hijau (Vigna radiata L.) Varietas Vima-1
Authors: Soelaksini Liliek Dwi , Yesi Vivin Apria , Herlinawati FNU
Published: September 2018

Penelitian aplikasi jenis pupuk organik padat dan MOL (Mikro Organisme Lokal) bonggol pisang bertujuan mengetahui respon produksi tanaman kacang hijau (Vigna radiata L.) varietas Vima-1. Penelitian ini dilaksanakan selama 4 bulan, mulai dari bulan oktober 2016 sampai febuari 2017 di lahan percobaan Politeknik Negeri Jember, Kecamatan Sumbersari, Kabupaten Jember. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 2 faktorial. Faktor pertama pemberian jenis pupuk organik padat (J) : tanpa pupuk kandang (J0), pupuk kandang ayam 2 kg/plot (J1), pupuk kandang kambing 2 kg/plot (J2). Faktor kedua pemberian konsentrasi MOL bonggol pisang : tanpa pemberian mol (M0), 100 ml/l air (M1), 200 ml/l air (M2), 300 ml/l air (M3), yang terdiri dari 12 kombinasi perlakuan dan 3 ulangan. Hasil penelitian menunjukkan bahwa perlakuan pupuk organik padat terutama pupuk kandang ayam berpengaruh nyata terhadap parameter tinggi tanaman 15 HST, 30 HST dan berat kering polong per sampel dan berpengaruh sangat nyata terhadap berat biji per sampel dan berat 100 biji. Perlakuan konsentrasi MOL bonggol pisang memberikan pengaruh berbeda nyata terhadap parameter jumlah cabang produktif. Interaksi jenis pupuk organik padat dan MOL bonggol pisang tidak memberikan pengaruh (non significant) terhadap semua parameter
Pemanfaatan Tanaman Bunga Marigold dan Kacang Hias Terhadap Populasi Arthropoda pada Tanaman Padi Sawah
Authors: Erdiansyah Iqbal , Ningrum Dwi Rahmawati Kusuma , Damanhuri FNU
Published: September 2018

Penelitian tentang Pemanfaatan tanaman bunga marigold dan kacang hias terhadap populasi arthropoda pada tanaman padi sawah untuk mengetahui populasi arthropoda pada tanaman padi sawah dengan memanfaatkan tanaman refugia sebagai tempat singgah musuh alami dan sebagai sumber pakan musuh alami. Tujuan dari penelitian ini dilakukan untuk mengetahui peranan refugia yaitu bunga marigold (Tagetes erecta L.), dan kacang hias (Arachis pintoi) sebagai mikrohabitat musuh alami, dalam upaya Pengelolaan Hama Terpadu (PHT) dalam budidaya padi. Penelitian ini dilaksanakan selama 5 bulan, yaitu mulai bulan November 2017 sampai bulan Maret 2018, bertempat di lahan Desa Antirogo, Kecamatan Sumbersari, Kabupaten Jember. Penelitian ini dilakukan dengan menggunakan tiga petak lahan penelitian berukuran 50 m2. Tiga petak lahan yaitu petak pertama perlakuan refugia  bunga Marigold, petak kedua perlakuan refugia Kacang Hias, dan petak ketiga tanpa refugia. Data hasil penelitian dianalisis secara statistik menggunakan uji t. Hasil penelitian menunjukkan bahwa pemanfaatan tanaman bunga Marigold dan Kacang Hias terhadap populasi arthropoda pada tanamana padi sawah diketahui populasi tertinggi musuh alami terdapat pada petak tanaman padi dengan refugia kacang hias sebanyak 217, dengan refugia Marigold populasi musuh alami sebanyak 156 sedangkan populasi terendah musuh alami terdapat pada petak tanaman padi tanpa refugia sebanyak 140. Penggunaan bunga marigold dan kacang hias berpengaruh terhadap populasi musuh alami.
Mô hình tham gia quản lý khoa học và công nghệ của cộng đồng: nghiên cứu trường hợp tỉnh Hà Nam
Authors: Nguyễn Mạnh Tiến
Published: September 2018

Quá trình tham gia quản lý khoa học và công nghệ của cộng đồng đang là một xu hướng phát triển mới ở Việt Nam. Sự phát triển này đáp ứng đòi hỏi ngày càng cao trong lĩnh vực khoa học và công nghệ và đời sống xã hội. Bài viết này sẽ tập trung trình bày 3 vấn đề chính. i. Khái quát các mô hình quản lý khoa học và công nghệ của cộng đồng hiện nay; ii. Tìm hiểu hai mô hình cộng đồng tham gia quản lý khoa học và công nghệ ở tỉnh Hà Nam; Đưa ra một số nhận xét, kiến nghị cho Hà Nam nói riêng và cả nước nói chung.
Chảy chất xám tại chỗ trong bối cảnh cuộc cách mạng công nghiệp 4.0: Một số vấn đề đặt ra
Authors: Dao Thanh Truong
Published: September 2018

Chảy chất xám không còn là câu chuyện của riêng quốc gia nào, nó đã trở thành một vấn đề chung của thế giới. Câu chuyện của chảy chất xám với thuật ngữ “brain drain” được sử dụng bắt đầu từ năm 1963, khi Hiệp hội hoàng gia Anh thấy sự suy giảm chất xám của các nhà khoa học từ Anh sang Mỹ, gây nguy hiểm cho nền kinh tế của Anh. Sau đó, thuật ngữ này được sử dụng rộng rãi để mô tả sự di chuyển của các chuyên gia, nhà khoa học từ các nước thứ ba[1]. Hay như ở Nga, chảy chất xám còn được gọi thêm bằng các tên khác nhau như: đánh cắp chất xám (brain theft) hay câu chất xám (brain bait). Thực chất đây không phải là vấn đề mới, đặc biệt vào cuối thế kỷ 17, đầu thế kỷ 18 khi Peter Đại đế thực hiện chính sách thu hút các chuyên gia có tài năng làm việc tại Nga. Vào đầu thế kỷ 20, trong cuốn “Tư bản và Công nhân”, V.I. Lenin đã đưa ra kết luận rằng “Nga ngày càng bị bùi lại phía sau, đưa cho ngoại quốc những người làm việc tốt nhất, trong khi Mỹ ngày càng tiến nhanh hơn, thu hút những phần dân số năng động và tài năng nhất của thế giới”[2]. Mặc dù được viết năm 1913 nhưng đến nay lời nhận định đó vẫn còn có giá trị.

Đó là những câu chuyện của những thế kỷ trước, bây giờ thế giới đã đổi khác rất nhiều, cả trên chiều cạnh lý luận và thực tiễn. Bài viết của tác giả sẽ so sánh quan điểm về chảy chất xám, xem xét các biểu hiện của chảy chất xám trong bối cảnh cuộc cách mạng 4.0 và đưa ra những vấn đề về chảy chất xám tại chỗ ở Việt Nam hiện nay
ANALYSIS OF DIAGNOSIS AND TREATMENT OF SEVERE HEMOLYTIC DISEASE OF THE FETUS
Authors: TURICHENKO O. V. , KORCHAGINA E. E. , LAPIN A. A.
Published: October 2018

Aim. The aim of the study is to evaluate the effectiveness of the modern methods of prenatal diagnosis and treatment of hemolytic  disease of the fetus based on the analysis of researchers’ own clinical material accumulated during 12 years.

Materials and methods. There was performed a prospective analysis of 210 pregnant women with RH-immunization with noninvasive methods of diagnosis and invasive methods of  treatment of HDF. Also there was conducted the analysis of the introduction of the specialized reception and monitoring of the  maximum systolic circulation rate (MSCR) increase in the middle cerebral artery (MCA) in the diagnosis of anemia of the fetus.

Results. The specialized reception of pregnant women with RH-immunization organized at the Perinatal Center in 2005 allowed us to carry out timely diagnostics of the anemic syndrome in the fetus and  made it possible to start the prenatal treatment primarily at the moderate severity stage of anemia. Pregnant women with the  edematous form of HDF entered the PC either with an established  diagnosis or it was determined during the first appointment at the PC.

Conclusion. As a result, we proved the effectiveness of the intrauterine treatment of severe forms of anemia in the fetus and showed the effectiveness of such tactics of management of pregnant women with RH-immunization.
STRUCTURAL AND FUNCTIONAL FEATURES OF LEFT VENTRICLE IN PATIENTS WITH HEART FAILURE, CORONARY HEART DISEASE AND THYROTOXICOSIS
Authors: PASHCHENKO E. V. , CHESNIKOVA A. I. , TERENTYEV V. P. , KUDINOV V. I. , DEVETYAROVA E. A.
Published: October 2018

Aim.This study was designed to determine the structural and functional features of left ventricle in patients with heart failure, coronary heart disease and thyrotoxicosis.

Materials and methods.85 patients aged 58.3±5.6 years were divided into 3 groups: the main one – 25 patients with coronary  heart disease (CHD), chronic heart failure (CHF) II-III functional  classes (FC) and thyrotoxicosis, average age –59.23±3.81; the 1st  comparison group – 30 patients with CHD and CHF FC II-III without  thyroid dysfunction, the average age – 57.6±2.73; the 2nd  comparison group – 30 patients with thyrotoxicosis without  concomitant cardiovascular diseases (CVD), the average age –  45.4±3.51. The structure and function of the thyroid gland were  examined in all patients. The echocardiographic (EchoCG)  examination was performed to evaluate the structural and functional  indicators of the left ventricle (LV).

Results.The LV pathologic remodeling in patients of the main group is represented by two types: concentric left ventricle hypertrophy  (CLVH) and eccentric left ventricle hypertrophy (ELVH), CLVH was  more common than in patients without thyroid dysfunction but with  CHF and CHD (84.0%, р=0.01). The LV myocardium contractility  was reduced in patients of both groups with CHF, the values of the ejection fraction corresponded with the intermediate type of HF, there was no significant difference between the indices (p = 0.1).  The main group had significantly more pronounced decrease in the ratio of the blood flow velocity of early diastolic filling of the LV  and the maximal atrial systolic velocity (E / A) − 0.63 and the  increase in the isovolumic relaxation time (IVRT) – 84.69 ms in  comparison with the indicators of the CHD and CHF patients without thyroid dysfunction (p = 0.021, p = 0.034).

Conclusion.For patients with CHF, CHD and thyrotoxicosis, predominance of LV remodeling according to the type of CLVH  (84.0% of cases) is typical as well as a moderate decrease in the  contractility of the LV and a more pronounced diastolic dysfunction.  It determines the structural and functional features of the left  ventricle in patients with CHF with this comorbidity.
COMPARATIVE ANALYSIS OF PHYSICAL DEVELOPMENT AND PHYSICAL EFFICIENCY OF MEDICAL STUDENTS
Authors: RUDEVA T. V. , PORUBAYKO L. N. , BOYCHENKO S. F.
Published: October 2018

Aim. This longitudinal study was conducted to examine the indicators of physical development and physical efficiency of students of the Kuban State Medical University during five years of their study.

Materials and methods. There was carried out a comparative analysis of the anthropometric data dynamics, the indices of physical development proportionality of Erismann, Pignier and Quetelet, and  the physical efficiency level of the students of the Kuban State Medical University during five years of their study.

Results. Physical development of the students almost has not changed by the 5th year of their study. It corresponds with the age standards of the examined group.

Conclusion. For optimizing the educational process during the physical education classes the physical activity of students needs to be increased as well as the amount of training in extracurricular time.