bluuebunny/crossref_metadata_2025 huggingface dataset:
Matrix-assisted laser desorption/ionization mass spectrometry imaging analysis revealed the spatial distribution of metabolites during Ziziphi Spinosae Semen at different growth periods
Authors: Zhao Mengwei , Liu Zhao , Wang Jiemin , Liu Yuting , Yan Yuping , Liu Ning , Jiang Jianming , Song Yongxing , Sun Huigai , Ma Donglai
Published: February 2025

Ziziphi Spinosae Semen (ZSS), a medicinal food, is one of the most popular Chinese medicinal herbs, known for its rich bioactive ingredients, such as terpenoids and flavonoids. The content of these bioactive ingredients in ZSS varies with age. However, the distribution of these bioactive ingredients throughout the developmental phases of ZSS—white maturity (S1), firm ripening (S2), and full ripening (S3)—and within specific tissues like the cotyledon, endosperm, and radicle, has not yet been determined. This research aimed to analyze the spatial distribution of key quality markers in ZSS and elucidate the metabolite quality characteristics throughout its growth stages. Utilizing matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI), 25 bioactive ingredients were identified and visualized in ZSS, including three terpenoids, seven flavonoids, four alkaloids, and eleven amino acids. The MALDI images revealed distinct spatial variations in the distribution of these bioactive ingredients across different regions of ZSS tissues and different growth stages. Moreover, as ZSS matured, the distribution area of specific bioactive ingredients significantly increased, encompassing three terpenoids, six flavonoids, two alkaloids, and seven amino acids. Utilizing ion imagery, Principal Component Analysis (PCA) coupled with Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) effectively differentiated samples from various developmental periods. Additionally, nine major bioactive ingredients were identified as potential quality markers for ZSS. This research demonstrates that the content and distribution of bioactive components in ZSS change during growth. The analysis provided by MALDI-MSI offers an experimental basis for understanding the accumulation and distribution of bioactive components during the maturation of ZSS.
Blue and red LEDs modulate polyphenol production in Precoce and Tardiva cultivars of Cichorium intybus L.
Authors: Menicucci Felicia , Marino Giovanni , Sillo Fabiano , Carli Andrea , dos Santos Nascimento Luana Beatriz , Detti Cassandra , Centritto Mauro , Brunetti Cecilia , Balestrini Raffaella Maria
Published: February 2025

Introduction

Plant growth and metabolism can be optimized by manipulating light intensity and wavelength. Since the use of light-emitting diodes (LEDs) allows easy regulation of the light spectrum, LEDs technology is largely tested to produce high-quality food. Red leaf chicory is a horticultural plant of high commercial value, rich in vitamins, minerals and phytochemical compounds with bioprotective and antioxidant roles.

Methods

Cichorium intybus L. (Asteraceae family) seedlings of the cultivar Rossa di Treviso Precoce and Rossa di Treviso Tardiva were cultivated under blue and red LEDs for three to four weeks, whereas white LEDs, proving full visible light spectrum, were supplied as control. The leaf polyphenols were characterized and quantified by HPLC-DAD-Q-ToF analysis, the leaf chlorophyll content was measured using a handheld optical analyzer and the photosystem II efficiency was assessed with a porometer-fluorometer.

Results

The PS II efficiency decreased in response to red LEDs treatment only. The highest levels of polyphenol and chlorophyll content were registered in response to blue LEDs exposure in both cultivars. The Rossa di Treviso Tardiva also exhibited a significant accumulation of polyphenols under red LEDs compared to white LEDs. The polyphenolic composition of the two cultivars significantly changed depending on the type of LEDs used. The leaf extracts of plants grown under red LEDs showed a prevalence of kaempferol 3-O-glucuronide, whereas a predominance of quercetin derivatives was found in response to white and blue LEDs. The comparison of the two cultivars revealed that the Rossa di Treviso Precoce was characterized by a higher content of polyphenols, independently of the type of LEDs.

Discussion

Species-specific protocols are required for producing high-content nutrient vegetables. In our study, red LEDs induced a completely different leaf polyphenol composition than blue and white LEDs, pointing out that an accurate light spectrum selection is crucial for shaping plant metabolism. Blue LEDs improved the content of photosynthetic pigments and induced an accumulation of highly antioxidant polyphenols in both Rossa di Treviso Precoce and Tardiva C. intybus cultivars, emerging as a valuable tool for improving their nutraceutical content.
Amorphophallus konjac: traditional uses, bioactive potential, and emerging health applications
Authors: Jain Archana , Sarsaiya Surendra , Gong Qihai , Wu Qin , Shi Jingshan
Published: February 2025

Amorphophallus konjac is a perennial plant native to Southeast Asia, renowned for its edible corms and rich nutritional value. The bioactive component, konjac glucomannan (KGM), has garnered significant attention due to its broad applications. This review aims to provide a comprehensive overview of the traditional uses, chemical and physical properties, and modern health applications of KGM. It highlights cutting-edge research, discusses challenges and limitations, and identifies future directions for advancing the utility of KGM in health and nutrition. KGM demonstrates remarkable health benefits, including improving metabolic health through weight management, blood glucose stabilization, and lipid profile enhancement. It also plays a vital role in gut health. Emerging evidence highlights its anti-inflammatory and immune-regulatory effects, with applications in managing inflammatory bowel disease, hyperthyroidism, and colorectal cancer (CRC). Recent advancements in multi-omics analyses and high-throughput screening (HTS) approaches have improved KGM extraction, characterization, and evaluation. However, potential side effects such as gastrointestinal discomfort and allergenicity, along with challenges in maintaining purity and molecular consistency, require careful consideration. KGM is a versatile dietary fiber with extensive applications in functional foods, nutraceuticals, and therapeutic interventions. Future research should focus on enhancing KGM's bioavailability, developing targeted delivery systems, and formulating novel applications.
Mycorrhizal fungus BJ1, a new species of Tulasnella sp.: its biological characteristics and promoting effect on seed germination of Bletilla striata
Authors: Li Zhengmei , Ye Yueyu , Wang Xia , Peng Suyu , Chen Beibei , Li Shiqing , Chen Haimin , Yang Dongfeng , Jiang Fusheng , Zhang Chunchun , Li Meiya
Published: February 2025

Mycorrhizal fungi have been shown to promote seed germination and seedling growth in Orchidaceae plants. In the present study, a mycorrhizal fungus designated as BJ1 was isolated from the roots of Bletilla striata (Thunb.) Reiehb.f. Fluorescence staining and morphological analysis revealed that this fungus exhibited characteristics highly similar to those of Tulasnella. Subsequently, the strain was confirmed as a new strain of Tulasnella through sequencing and phylogenetic analysis of four loci: the internal transcribed spacer region ITS1-ITS4 (ITS), ATP synthase (C14436), glutamate synthase (C4102), and ATP deconjugase (C3304). Additionally, we investigated the in vitro biological activity of strain BJ1 and its effects on germination and growth of B. striata seeds. The results indicated that BJ1 is capable of producing plant cell-degrading enzymes, including pectinase and protease. Furthermore, it demonstrates an ability to solubilize inorganic phosphorus and synthesize indoleacetic acid (IAA). Nevertheless, it does not exhibit laccase activity or possess the capacity to produce siderophores, nor can it solubilize organic phosphorus. Microscopic observations revealed that strain BJ1 mainly colonizes the base of the B. striata protocorm, thereby enhancing seed germination, growth, and expansion. Notably, by the fourth week of germination, 74.23% of seeds in the symbiotic group had developed to stage 5, a significantly higher proportion compared to 50.43% in the non-symbiotic group. Additionally, the length, width, and fresh weight of seeds in the symbiotic group were 2.2 times, 1.8 times, and 3.7 times greater than those in the non-symbiotic group, respectively. Furthermore, by adding L-tryptophan as a substrate during co-cultivation with BJ1, there was a significant enhancement in IAA synthesis capability; this also led to a marked acceleration in the symbiotic germination process of B. striata seeds. These results suggest that strain BJ1 holds significant potential for application in the artificial propagation of B. striata seedlings. It can enhance propagation efficiency and improve seedling quality, thereby playing a crucial role in the conservation and sustainable development of germplasm resources of endangered orchids.
How physical exercise enhances life satisfaction in Chinese senior college students: mediating roles of self-efficacy and resilience
Authors: Yu Huasen , Li Xuening , Yu Xin , Fusheng Liang , Li Liqiang , Yang Yuhang , Wu Jin
Published: February 2025

Objective

This study explored the relationship between physical exercise and life satisfaction among senior college students by focusing on the mediating roles of self-efficacy and resilience, thereby providing theoretical support for the mental health benefits of physical exercise for senior students.

Methods

A survey was conducted with 600 senior students from 10 universities using the physical exercise rating, life satisfaction, self-efficacy, and resilience scales. Data analysis was performed using SPSS 23.0 for descriptive statistics, correlation analysis, and reliability and validity assessments. In addition, AMOS software (version 24.0) was used to construct a structural equation model to test the hypothesized pathways and the effects of potential mediating variables.

Results

There were significant positive correlations among the variables of physical exercise, life satisfaction, self-efficacy, and resilience (r = 0.11–0.62, all p < 0.01). The structural equation model revealed that resilience fully mediated the relationship between physical exercise and life satisfaction among senior students (95% CI: 0.105–0.243), while self-efficacy did not mediate this relationship (β = 0.02, p = 0.77). However, a chain mediating effect involving self-efficacy and resilience was observed between physical exercise and life satisfaction (95% CI: 0.127–0.235).

Conclusion

Enhanced physical exercise can improve self-efficacy and resilience among senior college students, thereby increasing their life satisfaction.
Comparative efficacy of traditional non-pharmacological add-on treatments in patients with stable chronic obstructive pulmonary disease: a systematic review and network meta-analysis
Authors: Roh Ji-Ae , Leem Jungtae , Lee Beom-Joon , Kim Kwan-Il , Jung Hee-Jae
Published: February 2025

Chronic obstructive pulmonary disease (COPD) is a major global public health concern. In this study, we examined the comparative efficacy of non-pharmacological interventions within East Asian traditional medicine (EATM-NPI) for enhancing pulmonary function and exercise capacity in patients with stable COPD. A thorough search of electronic databases conducted until May 22, 2022, identified studies employing EATM-NPI in such patients. The evaluation focused on the impact adjunctive therapies on pulmonary function (forced expiratory volume in 1 s [FEV1]) and exercise capacity (6-min walking distance [6MWD]). The qualitative assessment encompassed 142 studies, with 133 studies included in one of three network meta-analyses. Participants, aged 49–76 years, ranged from 9 to 139 per group, predominantly from China (87.7% of studies). Overall study quality was generally low, and reported adverse events were mild. Notably, moxibustion and qigong adjunctive therapies demonstrated significant improvements in FEV1 (L) and FEV1 (%). Additionally, chuna, acupuncture, qigong and moxibustion adjunctive therapies were associated with significant improvements in 6MWD. In conclusion, EATM-NPI adjunctive therapy, when combined with standard pharmacological treatment, exhibited effects on pulmonary function and exercise capacity in patients with COPD.

Systematic review registration: The protocol was registered with PROSPERO (CRD42023389431), https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023389431.
Advanced applications in chronic disease monitoring using IoT mobile sensing device data, machine learning algorithms and frame theory: a systematic review
Authors: Liu Yu , Wang Boyuan
Published: February 2025

The escalating demand for chronic disease management has presented substantial challenges to traditional methods. However, the emergence of Internet of Things (IoT) and artificial intelligence (AI) technologies offers a potential resolution by facilitating more precise chronic disease management through data-driven strategies. This review concentrates on the utilization of IoT mobile sensing devices in managing major chronic diseases such as cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes. It scrutinizes their efficacy in disease diagnosis and management when integrated with machine learning algorithms, such as ANN, SVM, RF, and deep learning models. Through an exhaustive literature review, this study dissects how these technologies aid in risk assessment, personalized treatment planning, and disease management. This research addresses a gap in the existing literature concerning the application of IoT and AI technologies in the management of specific chronic diseases. It particularly demonstrates methodological novelty by introducing advanced models based on deep learning, tight frame-based methodologies and real-time monitoring systems. This review employs a rigorous examination method, which includes systematically searching relevant databases, filtering literature that meets specific inclusion and exclusion criteria, and adopting quality assessment tools to ensure the rigor of selected studies. This study identifies potential biases and weaknesses related to data collection, algorithm selection, and user interaction. The research demonstrates that platforms integrating IoT and machine learning algorithms for chronic disease monitoring and management are not only technically viable but also yield substantial economic and social advantages in real-world applications. Future studies could investigate the use of quantum computing for processing vast medical datasets and novel techniques that merge biosensors with nanotechnology for drug delivery and disease surveillance. Furthermore, this paper examines recent progress in medical image reconstruction, emphasizing tight frame-based methodologies. We discuss the principles, benefits, and constraints of these methods, assessing their efficacy across diverse application contexts.
Meritocracy or malfeasance: violations of meritocracy erode civic rule following
Authors: Kline Reuben , Galeotti Fabio , Orsini Raimondello
Published: February 2025

The perceived legitimacy of institutions, along with the voluntary compliance with authority that it undergirds, is crucial for stable governance and economic development. Legitimacy varies greatly across individuals and societies. We introduce a simple model of meritocratic equity—the notion that in a social exchange, individuals should receive greater compensation if their contributions exceed those of others. We argue that violations of meritocratic equity undermine the legitimacy of authority, leading to breaking rules, laws and civic norms—behaviors we refer to as justified malfeasance—in an effort to reduce perceived inequity. Using data from an incentivized laboratory experiment conducted in the United States and Italy and complemented by data from the World Values Survey, we investigate the effect of meritocratic violations on malfeasance. We find convergent evidence that meritocratic inequity explains variation in justified malfeasance across individuals and across countries. We conclude by discussing the implications of our results for multiple equilibria in societal levels of malfeasance and voluntary compliance with authority.
Time to initiation of antiresorptive agents in multiple myeloma to reduce skeletal related events
Authors: Bhasin Amman , Binder Adam Finn , Damron Leland , Majeed Amry , Barsouk Adam , Hughes Kelly , Raj Niketa , Abdulkareem Abdullateef O. , Zhan Tingting , Polu Divya , Gundepalli Sai , Devarakonda Srinivas
Published: February 2025

Purpose

Current treatment guidelines strongly support the use of antiresorptive therapy in patients with newly diagnosed multiple myeloma (NDMM) with the goal of preventing skeletal related events (SRE). Despite these concrete, data-driven recommendations, the impact of delays in antiresorptive initiation in NDMM patients is understudied. Through a multicenter retrospective study, we examined the impact of delays in antiresorptive initiation on the rates of SREs. We furthered our exploration of this topic in a separate retrospective analysis with a focus on reasons for delays in antiresorptive therapy initiation.

Methods

Electronic health records from two large academic institutions were used to identify patients with NDMM between July 1, 2016, and June 30, 2019. Exclusion criteria included patients with previous antiresorptive use and patients never prescribed antiresorptives. Time to antiresorptive initiation and its subsequent impact on the rate of SREs was analyzed using hazard ratios. A follow up, single-center retrospective study was conducted using EHR data with an emphasis on the identification of barriers to antiresorptive initiation. Here, descriptive, and inferential statistics were used to identify variables that have a statistically significant impact on antiresorptive initiation.

Results

A total of 759 patients with newly diagnosed MM met inclusion criteria for our multicenter study. Our study found that a delay in initiation of anti-resorptive therapy of greater than 31 days from diagnosis resulted in an increased risk for SRE with a hazard ratio of 1.654 (95% CI: 1.054-2.598; p-value = 0.029). In our follow up study, a total of 45.6% of patients with newly diagnosed MM were prescribed antiresorptive therapy, while 59% of patients with identified lytic lesions on screening imaging received anti-resorptive therapy. Statistically insignificant differences were observed in the time to initiation of anti-resorptive therapy based on health insurance. Variables such as race and gender were not found to have a statistically significant relationship with delays in antiresorptive initiation.

Conclusions

Patients with NDMM should be initiated on antiresorptive therapy without delay to minimize the rates of SREs, and clinicians should be diligent in anticipating delays in initiation such as need for dental clearance and renal disease.
Case Report: Repetitive peripheral magnetic stimulation and task-oriented training improve motor function in chronic severe post-stroke paralysis
Authors: Yamamoto Satoshi , Aoyama Toshiyuki , Ishii Daisuke , Ishibashi Kiyoshige , Kohno Yutaka
Published: February 2025

Background

Severe upper-limb motor paralysis following chronic stroke presents a significant rehabilitation challenge, often with limited recovery. This case study explores the effects of repetitive peripheral magnetic stimulation (rPMS) combined with task-oriented training on motor recovery in a patient with chronic stroke and severe upper-limb impairment.

Methods

A 50-year-old male with right upper-limb paralysis post-hemorrhagic stroke underwent a 2-week intervention comprising 12 sessions of rPMS targeting the elbow and wrist extensors, combined with task-oriented training. Motor function was assessed using the Fugl-Meyer Assessment (FMA), kinematic analysis, Motor Activity Log (MAL), and electromyographic (EMG) analysis of wrist flexion-extension movements.

Results

The intervention resulted in a clinically meaningful increase in motor function, reflected in improved FMA scores and greater elbow extension during kinematic analysis. EMG analysis demonstrated reduced co-contractions of wrist flexors and extensors, indicating improved muscle coordination. Despite these gains, recovery of distal voluntary movements, such as wrist dorsiflexion and finger extension, remained limited. As assessed by MAL, upper-limb usage in daily activities showed minor improvements; however, qualitative reports indicated functional gains, including the ability to hold a bottle and assist in closing a car door.

Conclusion

rPMS combined with task-oriented training shows promise in enhancing motor function in patients with chronic stroke combined with severe upper-limb paralysis, particularly in proximal muscles. Further research involving control groups and objective measures of upper-limb use is necessary to validate these findings and refine intervention protocols.
Noise and Dynamical Synapses as Optimization Tools for Spiking Neural Networks
Authors: Garipova Yana , Yonekura Shogo , Kuniyoshi Yasuo
Published: February 2025

Standard ANNs lack flexibility when handling corrupted input due to their fixed structure. In this paper, a spiking neural network utilizes biological temporal coding features in the form of noise-induced stochastic resonance and dynamical synapses to increase the model’s performance when its parameters are not optimized for a given input. Using the analog XOR task as a simplified convolutional neural network model, this paper demonstrates two key results: (1) SNNs solve the problem that is linearly inseparable in ANN with fewer neurons, and (2) in leaky SNNs, the addition of noise and dynamical synapses compensate for non-optimal parameters, achieving near-optimal results for weaker inputs.
Bias Estimation for Low-Cost IMU Including X- and Y-Axis Accelerometers in INS/GPS/Gyrocompass
Authors: Fukuda Gen , Kubo Nobuaki
Published: February 2025

Inertial navigation systems (INSs) provide autonomous position estimation capabilities independent of global navigation satellite systems (GNSSs). However, the high cost of traditional sensors, such as fiber-optic gyroscopes (FOGs), limits their widespread adoption. In contrast, micro-electromechanical system (MEMS)-based inertial measurement units (IMUs) offer a low-cost alternative; however, their lower accuracy and sensor bias issues, particularly in maritime environments, remain considerable obstacles. This study proposes an improved method for bias estimation by comparing the estimated values from a trajectory generator (TG)-based acceleration and angular-velocity estimation system with actual measurements. Additionally, for X- and Y-axis accelerations, we introduce a method that leverages the correlation between altitude differences derived from an INS/GNSS/gyrocompass (IGG) and those obtained during the TG estimation process to estimate the bias. Simulation datasets from experimental voyages validate the proposed method by evaluating the mean, median, normalized cross-correlation, least squares, and fast Fourier transform (FFT). The Butterworth filter achieved the smallest angular-velocity bias estimation error. For X- and Y-axis acceleration bias, altitude-based estimation achieved differences of 1.2 × 10−2 m/s2 and 1.0 × 10−4 m/s2, respectively, by comparing the input bias using 30 min data. These methods enhance the positioning and attitude estimation accuracy of low-cost IMUs, providing a cost-effective maritime navigation solution.
Administración pública central y fortalecimiento de emprendimientos asociativos en Loja, Ecuador 2018-2021
Authors: Freire Granda Laura Gabriela , Poveda Guevara Antonio , Luis Reyes José
Published: February 2025

En las últimas décadas, el emprendimiento ha adquirido una importancia significativa para empresas, academias y gobiernos, debido a su impacto en el tejido empresarial de un país. Este estudio se centra en analizar la intervención de la Administración Pública del Gobierno Central en el fomento de emprendimientos asociativos en Loja entre 2018 y 2021, utilizando una metodología bibliográfica-explicativa y un enfoque cuantitativo con una población de 1,380 emprendimientos. Se identificó la relación entre emprendimientos y financiamiento mediante un modelo de regresión lineal y se aplicó una técnica estadística descriptiva-causal para el análisis de datos. En cantones como Espíndola, Gonzanamá, Olmedo, Quilanga y Sozoranga se observa la ausencia de banca pública, mientras que en Olmedo y Quilanga no hay participación de la banca privada. Las investigaciones han demostrado que factores sociales, institucionales y económicos influyen directamente en la actividad emprendedora
Adenovirus Interstitial Nephritis post-Kidney Transplant
Authors: Monteiro Cutrim Ézio Arthur , Garcia Campos Marcos Adriano , Strand Eleanor , Monteiro Cutrim Érico Murilo , Sodré Andressa Monteiro , Carvalho de Araújo Emmy Marjorie , Barros de Sousa Pedro Manuel , Alves Ferreira Teresa Cristina , Wagner de Castro Lima Santos Daniel , de Almeida Araújo Stanley , Filho Natalino Salgado , Barros Silva Gyl Eanes
Published: February 2025

Background:

Post-kidney transplant adenovirus nephritis is a condition with potential for acute allograft dysfunction, and evidence on its management is scarce.

Methods:

The present study is an original case series based on kidney biopsy of seven patients obtained at a health center specialized in kidney pathology from 2009 to 2023. We also performed a non-systematic literature review on cases described in the literature.

Results:

Kidney biopsy was used to define the diagnosis of all patients. The average time to diagnosis after transplantation was 32.9 months. The most prevalent symptoms were fever, macroscopic hematuria, and dysuria. The glomerular filtration rate (GFR) reduced on average four times in relation to the baseline GFR. The main findings of kidney biopsy were acute tubular necrosis (100%), necrotizing granulomatous interstitial nephritis (100%) and viral inclusions (100%). The therapies used were human immunoglobulins, antivirals, and reduction of immunosuppression. The clinical course was favorable in six of the seven patients. Our literature review found 44 cases of adenovirus interstitial nephritis, and the outcome was favorable in the majority of reported cases.

Conclusions:

Adenovirus interstitial nephritis is a rare condition, but with important implications for kidney transplant recipients. Kidney biopsy plays a very important role in confirmation. This study fills gaps in the current literature on adenovirus interstitial nephritis and contributes to the understanding of this potential complication in the follow-up of kidney transplant recipients.
Analysis of Cardiovascular and Cerebrovascular Prognosis and Risk Factors in Patients with Primary Membranous Nephropathy
Authors: Ye Nan , Yang Lei , Wang Guoqin , Cheng Wenrong , Xie Bing , Dong Hongrui , Kong Lingqiang , Zhao Xiaoyi , Geng Yanqiu , Cheng Hong
Published: February 2025

Background:

This study investigated risk factors and possible mechanisms of arterial and venous thromboembolic events in patients with pMN.

Methods:

Patients with pMN confirmed by renal biopsy from June 1, 2010 to March 3, 2023 were included, and the study outcome was set as a composite endpoint of acute coronary syndrome, heart failure, cerebral infarction, arrhythmia, pulmonary embolism, deep venous thrombosis and all-cause mortality.

Results:

A total of 433 pMN patients with complete data were included, with a median follow-up time of 73 (45.5–101.6) months and a composite endpoint rate of 10.2%. We divided all patients with events into early event group (events occurring in the first 2 years after renal biopsy) and late event group (events occurring after 2 years after renal biopsy) according to the time of event. It showed a lower serum albumin and a higher baseline value of serum PLA2R antibody titer and mean value of each follow-up in the early event group compared with the late event group. Cox proportional hazards model showed that after adjusting for confounding factors, in addition to older age, history of deep vein thrombosis and higher urinary protein, higher baseline serum PLA2R antibody titers (OR 1.034, 95% CI 1.006 -1.063, P = 0.015), and high hsCRP level (OR 1.049, 95% CI 1.002 -1.098, P = 0.041), renal pathology with segmental sclerotic lesions (OR3.480, 95% CI 1.338 –9.050, P = 0.011) were also independent risk factors for the occurrence of endpoint events. The results also showed that baseline serum IL-6 levels were significantly higher in the event group compared with the non-event group (4.25 pg/ml vs. 3.21 pg/ml), and the difference was statistically significant (P = 0.009).

Conclusions:

In the early event group, higher serum PLA2R antibody and renal pathology with segmental sclerosis lesions may affect the occurrence of cardiovascular and cerebrovascular events and venous thrombotic events. The inflammatory system may play a role in this relationship.
Quantification of Pigmented Regions in Detracted Images
Authors: Eugênio Rocha da Silva Júnior  , Uanderson Lima Santos  , Marcos Batista Figueredo
Published: February 2025

This study presents a method for analyzing and quantifying pigmented areas on dental surfaces after the application of caries detection products. The methodology integrates image enhancement, the creation of binary masks, and conversion to the HSV color space to isolate and accurately calculate the extent of pigmentation. A dataset consisting of 200 images of unpigmented teeth and 200 images of pigmented teeth was used, with strict criteria for selecting images that provided a clear frontal view, focusing on the upper and lower canine regions. The image processing steps included using LabelMe software for manual annotation and applying binary masks to segment the teeth from the background. Specific color filters identified pigmented regions. Histogram analysis in the HSV space validated the predominance of red shades corresponding to the pigmented areas, confirming the accuracy of the segmentation. The results demonstrate the effectiveness of the proposed method for calculating pigmented areas, providing an objective measure that can be used to assess the efficacy of products designed for bacterial plaque detection in dental applications.
Креативный учет: сущность и оценка в ходе судебно-бухгалтерской экспертизы
Authors: Пащенко Т.В. , Халилова Д.Р.
Published: February 2025

Важным условием успешного развития финансово-хозяйственной деятельности организации является ведение бухгалтерского учета в соответствии с законодательством и формирование достоверных показателей отчетности, которые служат основой принятия управленческих решений. В последнее время в современном бухгалтерском учете нередко стали использовать понятие «креативный» учет, сущность которого не до конца установлена как с научной, так и с методической позиции. Всё это ещё больше усложняет задачу бухгалтера-эксперта, когда нужно на основе данных бухгалтерского учета установить какие-либо факты о деятельности организации. Целью данной работы является установление причин возникновения и развития креативного учета, выделение его особенностей, выявление проблемных сторон и внесение предложений по решению спорных вопросов в ходе производства судебно-бухгалтерских экспертиз. В результате исследования сделан вывод о том, как можно использовать позитивные и негативные проявления креативного учёта и оценивать их в ходе судебно-бухгалтерской экспертизы.

An important condition for the successful development of the financial and economic activities of an organization is accounting in accordance with the legislation and the formation of reliable reporting indicators for management decisions. Recently, in modern accounting, the concept of «creative» accounting has often begun to be used, the essence of which is not fully clarified. The purpose of this work is to disclose the essence of creative accounting, identify problematic parties and make proposals for resolving controversial issues. As a result of the research, it was concluded that it is worthwhile to rationally use the positive aspects of creative accounting and limit its negative manifestations.
Обзор финансового результата деятельности организации
Authors: Рознина Н.В. , Карпова М.В. , Лапина Е.Н.
Published: February 2025

Актуальность исследуемого вопроса обусловлена тем, что финансовый результат деятельности хозяйствующих субъектов - важнейший элемент рыночной экономики [15]. Роль прибыли хозяйствующих субъектов сложно переоценить, так как она является конечным финансовым результатом организации и выступает источником пополнения её финансовых ресурсов [14]. Получаемая прибыль позволяет хозяйствующим субъектам осуществлять расширенное воспроизводство и удовлетворять социальные и материальные потребности учредителей и работников [7]. Посредством прибыли выполняются обязательства хозяйствующих субъектов перед бюджетом, внебюджетными фондами, кредитными организациями, иными учреждениями. В работе проведена оценка состава и структуры доходов и расходов АО «НПО «Курганприбор», проанализирована динамика показателей прибыли и рентабельности. Проведён операционный анализ. Предложены и экономически обоснованы мероприятия по повышению уровня финансовых результатов организации.

The relevance of the issue is due to the fact that the financial result of economic entities is an important element of the market economy. The role of profit of economic entities is difficult to overestimate, since it is the final financial result of the organization's activities and acts as a source of replenishment of its financial resources. The resulting profit allows economic entities to carry out expanded reproduction and meet the social and material needs of founders and employees. At the expense of profit, the obligations of economic entities to the budget, extra-budgetary funds, credit organizations and other institutions are fulfilled. The article assesses the composition and structure of revenues and expenses of JSC " NPO "Kurganpribor", analyzes the dynamics of profit and profitability indicators. An operational analysis was carried out. Proposed and economically justified measures to improve the level of financial results of the organization.
Экономическое обоснование возделывания льна в Курганской области
Authors: Дуничева С.Г. , Карпова М.В. , Рознина Н.В.
Published: February 2025

В Курганской области традиционным является возделывание зерновых культур, но рыночные отношения диктуют применение смешанного возделывания, например, введение льна в севооборот. Льноводство считается доходной отраслью, хотя при этом остаётся достаточно трудоёмкой. В Курганской области площади, занимаемые льном, увеличились с 2750 га в 2012 году до 87374 га в 2020 году, при этом масличный лён занимает в структуре 84364,1 га или 96,6%, большая его часть приходится на сорт Северный. Анализ экономической эффективности получения семян различных сортов льна показал, что условно чистый доход колеблется от 35965 до 37345 рублей и окупаемость затрат в вариантах опыта выросла с 2,60 до 4,61 по сравнению с контролем, что указывает на доходность данной отрасли производства.

In the Kurgan region, grain cultivation is traditional, but market relations dictate the use of mixed cultivation, for example, the introduction of flax in crop rotation. Flax growing is considered a profitable industry, although it remains quite labor-intensive. In the Kurgan region, the area occupied by flax increased from 2,750 hectares in 2012 to 87,374 hectares in 2020, while oilseed flax occupies 84,364. 1 hectares or 96.6%, most of it falls on the Northern variety. An analysis of the economic efficiency of obtaining seeds of various flax varieties showed that the conditional net income ranges from 35965 to 37345 rubles and the cost recovery in the experimental variants increased from 2.60 to 4.61 compared to the control, which indicates the profitability of this industry.
Особенности бухгалтерского учета готовой продукции в сельскохозяйственной организации
Authors: Калугина О.А. , Никулина С.Н. , Гривас Н.В.
Published: February 2025

Бухгалтерский учет - это сложная информационная система, Важная часть системы - учет готовой продукции. В данной статье на примере конкретной организации агропромышленного комплекса рассматриваются особенности бухгалтерского учета готовой продукции. Предлагаются направления по совершенствованию учета данного объекта исследования.

Accounting is a complex information system; an important part of the system is the accounting of finished products. In this article, on the example of a specific organization of the agro-industrial complex, the features of accounting for finished products are considered. Directions for improving the accounting of this object of research are proposed.
Бухгалтерский учёт в условиях применения технологии блокчейн
Authors: Антропова А.О. , Кокоулина Е.А. , Мурашова Ю.Г.
Published: February 2025

В условиях постоянных информационно-технологических нововведений бухгалтерский учет вынужден не только приспосабливаться к инновациям, но и применять их на практике. В статье рассмотрен процесс работы технологии блокчейн, его инвестиционная привлекательность, распространенность в различных сферах. Выделены основные условия, необходимые для функционирования технологии, как в целом, так и в учете. Посредством проведения SWOT-анализа изучены положительные и отрицательные стороны применения технологии в бухгалтерском учете. На основе анализа выявлены возможные изменения и дополнения в учетную политику предприятия, а также влияние на решение важнейших задач в организации и ведении бухгалтерского учета. Таким образом, был определен ряд задач в учете, который возникнет в связи с применением технологии блокчейн.

In the context of constant information and technological innovations, accounting is forced to adapt to innovations and also to apply them in practice. The article considers the process of blockchain technology, its investment attractiveness, prevalence in various fields. The main conditions which are necessary for the functioning of the technology, both in general and in accounting are highlighted. Through the SWOT analysis, the positive and negative aspects of the application of technology in accounting were studied. Based on the analysis, possible changes and additions to the accounting policy of the enterprise, as well as the impact on the solution of the most important tasks in organizing and maintaining accounting, were identified. As a result, a number of accounting tasks were determined that will arise from the use of blockchain technology.
Анализ современного состояния и конкурентоспособности ООО «Лузинское Зерно» Омского района Омской области
Authors: Хайдуков В.В. , Козленко Д.В. , Асташова Е.А.
Published: February 2025

обстоятельствах глобализации мировой экономики, быстрого преумножения конкуренции среди предприятий аграрного сектора на первое место выходит вопрос увеличения конкурентоспособности сельскохозяйственной продукции. Необыкновенно значительная роль отдается предельному употреблению существующих природно- экономических возможностей для изготовления определенных видов аграрной продукции. Вопросы повышения конкурентоспособности предприятия являются актуальными для ООО «Лузинское зерно», поскольку рыночная экономика заставляет сельскохозяйственные предприятия конкурировать друг с другом, а проблема выживания на конкурентном рынке и вопросы увеличения прибыли напрямую связаны с понятием конкурентоспособность предприятия.

. In the context of the globalization of the world economy, the rapid increase in competition among enterprises of the agricultural sector, the issue of increasing the competitiveness of agricultural products comes to the fore. An unusually significant role is given to the ultimate use of existing natural and economic opportunities for the manufacture of certain types of agricultural products. The issues of increasing the competitiveness of the enterprise are relevant for LLC «Luzinskoye Zerno», since the market economy forces agricultural enterprises to compete with each other, and the problem of survival in a competitive market and the issues of increasing profits are directly related to the concept of competitiveness of the enterprise.
Бухгалтерский учет расходов на предпродажную подготовку товаров
Authors: Васильева М.И. , Гривас Н.В. , Никулина С.Н.
Published: February 2025

Ключевые показатели в учетной системе торговых организаций: товарооборот, торговая наценка, издержки обращения. Оптимизация данных показателей способствует принятию эффективных оперативных и стратегических решений. Однако немаловажная роль принадлежит затратам на предпродажную подготовку товаров. С этих позиций в данной статье на примере конкретной торговой организации исследуется отражение в бухгалтерском учете расходов на предпродажную подготовку товаров. Предлагаются варианты ее отражения в учете, предусмотренные действующими нормативными документами.

Key indicators in the accounting system of trade organizations: trade turnover, trade margin, circulation costs. Optimization of these indicators contributes to the adoption of effective operational and strategic decisions. However, an important role belongs to the cost of pre-sale preparation of goods. From these positions, this article examines the reflection in accounting of the costs of pre-sale preparation of goods on the example of a specific trade organization. The variants of its reflection in the accounting provided by the current regulatory documents are offered.
Развитие альтернативного финансирования в России
Authors: Туаева Д.А.
Published: February 2025

. Статья посвящена исследованию альтернативной формы финансирования - краудфандингу, его преимуществам перед традиционным механизмом финансирования. Рассмотрены направления краудсектора, а также его динамика в мире, изложены достижения данного сектора и его потенциал. Альтернативное финансирование это сфера, которая развивается в помощь целому ряду отраслей. Краудфандинг - коллективное сотрудничество людей, которые добровольно объединяют свои деньги или другие ресурсы вместе, как правило, через Интернет, чтобы поддержать усилия других людей или организаций. Государство, финансовые институты развития далеко не исчерпали весь спектр возможностей стимулирования предпринимательской деятельности, однако альтернативные формы заимствования могут окончательно сформироваться как реальный сегмент финансовой отрасли и составить конкуренцию банкам. Таким образом, в условиях сложной экономической ситуации и явного дефицита финансовых ресурсов, стратегия развития данного рынка требует детального изучения.

The article is devoted to the study of an alternative form of financing - crowdinvesting, its advantages over the traditional financing mechanism. The directions of the crowd sector, as well as its dynamics in the world are considered, the achievements of this sector and its potential are outlined. Alternative finance is an area that is developing to help a variety of industries. Crowdfunding is a collective collaboration of people who voluntarily pool their money or other resources together, usually over the Internet, to support the efforts of other people or organizations. The state and financial development institutions have far from exhausted the full range of opportunities to stimulate entrepreneurial activity, however, alternative forms of borrowing can finally emerge as a real segment of the financial industry and compete with banks. Thus, in a difficult economic situation and an obvious shortage of financial resources, the development strategy of this market requires a detailed study.
Цифровизация образования в условиях пандемии
Authors: Иваев М.И. , Юдакова Е.П. , Беляева А.В.
Published: February 2025

Из-за пандемии коронавируса в начале 2020 года в России были введены ограничения на передвижение и трудовую занятость населения, а также на организации в сфере образования. В статье говорится о влияние таких мер на российскую систему образования. Грамотное использование цифровых возможностей может оптимизировать учебный процесс. В итоге педагоги избавятся от нагрузки, и образовательный процесс станет более творческим. Конечно, этот вынужденный эксперимент прошел не совсем удачно. Но он позволит создать современное и безопасное цифровое пространство для учебы, обеспечив высокое качество и доступность знаний.

Due to the coronavirus pandemic in early 2020, restrictions were imposed on the movement and employment of the population, as well as on organizations in the field of education. The article discusses the impact of such measures on the Russian education system. Proper use of digital capabilities can optimize the learning process. As a result, teachers will get rid of the load, and the educational process will become more creative. Of course, this forced experiment was not entirely successful. But it will create a modern and secure digital space for learning, ensuring high quality and accessibility of knowledge.
Бухгалтерский учет накладных расходов и их распределение
Authors: Никулина С.Н.
Published: February 2025

По экономическому содержанию все расходы делят на основные и накладные. Основные затраты связанные с процессом изготовления продукции (выполнения работ, оказания услуг): материалы, заработная плата производственных рабочих и т.д. Накладные – это затраты по управлению и обслуживанию производственного процесса. В данной статье на примере конкретной организации исследуется учет накладных расходов. Предлагаются рекомендации по совершенствованию данного объекта исследования.

According to the economic content, all expenses are divided into basic and overhead. The main costs associated with the process of manufacturing products (performing works, providing services): materials, wages of production workers, etc. Overhead costs are the costs of managing and maintaining the production process. In this article, using the example of a specific organization, we study the accounting of overhead costs. Recommendations for improving this object of research are offered.
Учетная политика коммерческих организаций: Методология формирования и механизм реализации
Authors: Асфандиярова И.Р.
Published: February 2025

В данной статье рассматриваются особенности реализации учетной политики коммерческих организаций в части методологии ее формирования и механизмов реализации. Учетная политика предприятия рассматривается как совокупность методов и способов ведения бухгалтерского учета. Важное замечание сделано по необходимости формирования оптимальной учетной политики, не делая ее слишком объемной и громоздкой. В заключении сделаны выводы и предложения по применению механизмов ведения учетной политики, с точки зрения оптимальности ее применения

The article discusses the features o f the implementation o f accounting policies o f commercial organizations in terms o f the methodology o f its formation and implementation mechanisms. Accounting policy o f the enterprise is considered as a set o f methods and methods o f accounting. An important note is made on the need to develop an optimal accounting policy without making it too voluminous and cumbersome. In conclusion, the findings and suggestions for applying the mechanisms for the maintenance o f accounting policies, from the point o f view o f an optimality o f its application.