bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger
Authors: Issa Ibrahima , Lamine Mahaman Moustapha , Hubert Veronique , Ilagouma Amadou , Adehossi Eric , Mahamadou Aboubacar , Lobo Neil F. , Sarr Demba , Shollenberger Lisa M. , Sandrine Houze , Jambou Ronan , Laminou Ibrahim Maman
Published: August 2022

The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that of artemisinin but also on that of partner molecules. This study aims to evaluate the prevalence of mutations in the Pfdhfr, Pfdhps, and Pfmdr1 genes from isolates collected during a clinical study. Plasmodium genomic DNA samples extracted from symptomatic malaria patients from Dogondoutchi, Niger, were sequenced by the Sanger method to determine mutations in the Pfdhfr (codons 51, 59, 108, and 164), Pfdhps (codons 436, 437, 540, 581, and 613), and Pfmdr1 (codons 86, 184, 1034, and 1246) genes. One hundred fifty-five (155) pre-treatment samples were sequenced for the Pfdhfr, Pfdhps, and Pfmdr1 genes. A high prevalence of mutations in the Pfdhfr gene was observed at the level of the N51I (84.97%), C59R (92.62%), and S108N (97.39%) codons. The key K540E mutation in the Pfdhps gene was not observed. Only one isolate was found to harbor a mutation at codon I431V. The most common mutation on the Pfmdr1 gene was Y184F in 71.43% of the mutations found, followed by N86Y in 10.20%. The triple-mutant haplotype N51I/C59R/S108N (IRN) was detected in 97% of the samples. Single-mutant (ICS and NCN) and double-mutant (IRS, NRN, and ICN) haplotypes were prevalent at 97% and 95%, respectively. Double-mutant haplotypes of the Pfdhps (581 and 613) and Pfmdr (86 and 184) were found in 3% and 25.45% of the isolates studied, respectively. The study focused on the molecular analysis of the sequencing of the Pfdhfr, Pfdhps, and Pfmdr1 genes. Although a high prevalence of mutations in the Pfdhfr gene have been observed, there is a lack of sulfadoxine pyrimethamine resistance. There is a high prevalence of mutation in the Pfmdr184 codon associated with resistance to amodiaquine. These data will be used by Niger’s National Malaria Control Program to better monitor the resistance of Plasmodium to partner molecules in artemisinin-based combination therapies.
Antimicrobial Stewardship in Tropical Infectious Diseases: Focusing on Dengue and Malaria
Authors: Siribhadra Ashley , Ngamprasertchai Thundon , Rattanaumpawan Pinyo , Lawpoolsri Saranath , Luvira Viravarn , Pitisuttithum Punnee
Published: August 2022

Acute undifferentiated febrile illness (AUFI) is the presenting symptom of various tropical and infectious diseases. Viral infection is generally the most common cause of AUFI, accounting for 8–11.8% of cases; thus, antibiotics might be unnecessary. Dengue and malaria are common tropical infectious diseases requiring effective supportive treatment and antimalarial agents, respectively. The uncertainty of early diagnosis results in widespread empirical antimicrobial treatment in high -income as well as in low-and middle-income countries. Although rapid diagnostic tests (RDTs) have been shown to limit antibiotic prescriptions in dengue and malaria, we observed a wide range of antibiotic prescriptions for 13–92.7% of cases in previous literature, particularly in RDT-negative malaria cases. Given several RDT limitations, antimicrobial stewardship (AMS) appears to be an effective strategy for controlling unnecessary antibiotic use and antimicrobial resistance (AMR) prevention. This program should be endorsed by a multidisciplinary team in tropical diseases to control collateral damage of inappropriate antimicrobial use. Empirical antibiotic treatment should be administered based on clinical judgement, microbiological evidence, and local epidemiological data. Rapid termination of antibiotic therapy, including disease control or elimination, is the mainstay of AMS in tropical diseases. Local and international sectors should implement an AMS programme to reduce AMR in the Tropics.
Vaccine Coverage and Effectiveness in a School-Based Varicella Outbreak in Jinan Prefecture, Shandong Province
Authors: Liu Xiaoxue , Li Quanxia , Du Xu , Zhao Xiaodong , Yin Zundong
Published: August 2022

Background: Licheng District of Jinan Prefecture reported a school-based varicella outbreak. We conducted an investigation to analyze the epidemiology and scope of the outbreak, determine varicella vaccine coverage on the school campus, and estimate varicella vaccine effectiveness (VE). Methods: In the epidemiological investigation, we determined the attack rate, the clinical manifestations of varicella cases, and histories of prior varicella disease and varicella vaccination. We tested students for presence of serum IgM antibodies, and we attempted to isolate the varicella virus from vesicular fluid samples. We used chi-square to compare incidences between classes and floors. VE was estimated using a retrospective cohort study. Results: There were 13 varicella cases in the outbreak. All were among fourth grade students - twelve in Class 7 and one in Class 6. The attack rate in the two classrooms was 14.3% (13/91). Clinical symptoms were rash (100%) and fever (46.15%). All cases were reported within one average incubation period, and the epidemic curve suggested common exposure. Six of the 13 cases previously received one dose of varicella vaccine with a median time between vaccination and infection of 9 years; the other seven cases had not been vaccinated. Varicella vaccine coverage with one or more doses was 81.31%; 2-dose coverage was 38.15%. The median age of receipt of dose 1 was 1.18 years, and median age for receiving dose 2 was 5.12 years. One-dose varicella VE was 73.2% (95% confidence interval: 37.0%, 88.6%), and two-dose VE was 100%. Conclusions: Varicella vaccine coverage has been gradually increasing in recent years, as ≥1-dose and 2-dose coverage rates are higher in younger children than older children. High one-dose vaccination coverage limited the outbreak scope and led to the breakthrough cases being mild. Mild cases were difficult to detect in a timely manner. Varicella vaccine was highly effective, with 1-dose VE of 73% nine years after vaccination and 2-dose VE of 100%. We strongly recommended that all school students receive two doses of varicella vaccine.
Charging Electric Vehicles Today and in the Future
Authors: Leijon Jennifer , Boström Cecilia
Published: August 2022

It is expected that more vehicles will be electrified in the coming years. This will require reliable access to charging infrastructure in society, and the charging will include data exchange between different actors. The aim of this review article is to provide an overview of recent scientific literature on different charging strategies, including for example battery swapping, conductive- and inductive charging, and what data that may be needed for charging of different types of electric vehicles. The methodology of the paper includes investigating recent scientific literature and reports in the field, with articles from 2019 to 2022. The contribution of this paper is to provide a broad overview of different charging strategies for different types of electric vehicles, that could be useful today or in the coming years. The literature review shows that data utilized for charging or discharging includes for example information on the battery, temperature, electricity cost, and location. It is concluded that the preferred charging strategy for an electric vehicle may depend on the type of electric vehicle and when, where, and how the vehicle is used.
Wireless Power Transfer Positioning System with Wide Range Direction-Guided Based on Symmetrical Triple-U Auxiliary Pad
Authors: Yang Yi , Cao Guimei , Zhang Ge , Xie Shiyun
Published: August 2022

An important area of research in electric vehicle wireless power transfer systems is the detection of the secondary pad, which is vital evidence to determine whether the vehicle is in the effective charging area. However, the detection based on sensors mostly will reconstruct the vehicle structure and has a limit on versatility in all kinds of vehicles and the applicability of magnetic couplers and the influence on the primary pad. Therefore, an auxiliary pad structure and corresponding positioning method for offset estimation utilizing the existing inverter and secondary pad in the vehicle system are proposed. Firstly, to satisfy the needs of different positioning heights and avoid the effect on the primary pad, a triple-U positioning auxiliary pad is designed to assist positioning. Secondly, the direction-guided trajectory and detection algorithm are proposed to modify the vehicle location in real-time after analyzing the corresponding equivalent mutual inductance feature trajectory, according to the magnetic field characteristics of various typical magnetic couplers intervened by the proposed triple-U auxiliary pad. Finally, a prototype system is built to validate the applicability and feasibility of the triple-U auxiliary pad, where the positioning accuracy is within 10 mm, and the maximum recognizable recognition range can reach 300 mm × 300 mm, and the direction-guided trajectory is accurate, which can satisfy the actual positioning requirements of electric vehicles.
Bone Lesions in a Young Dog and a NEEM (Azadirachta indica) Spray as the Only Preventive Measure against Leishmaniasis: A Case Report
Authors: De Feo Giulia , Lubas George , Citi Simonetta , Puccinelli Caterina , Papini Roberto Amerigo
Published: August 2022

As the spread of canine leishmaniasis (CanL) is increasing throughout the world, the need for effective agents to prevent its transmission has intensified. In this case report, an intact 1.5-year-old male French bulldog was presented for treatment of severe, sudden, and constant lameness on his right hindlimb, which had started approximately four months previously and was unresponsive to routine nonsteroidal anti-inflammatory drugs. A Neem oil-based product was sprayed three times a week on the dog’s coat for about fourteen months as the only prophylactic measure against CanL. The orthopedic examination revealed grade 3–4 lameness and marked atrophy of the thigh muscles with swollen and painful right stifle joint. The radiological investigation showed polyostotic periosteal proliferation at both hindlimbs. The diagnosis of CanL was established by examination of fine-needle aspiration of lymph nodes (left prescapular, right and left popliteal) and immunofluorescence antibody testing. A leishmanicidal therapeutic protocol was prescribed. Within ten days of starting the therapy, the dog was significantly less lame, and eight months later radiographic examination revealed complete regression of the bone lesions. Some owners resort to a naturalistic approach for CanL prevention, also using products that have not been clinically evaluated. Neem oil is thought to prevent sandfly bites in dogs. Some laboratory and field studies have identified Neem oil as a possible alternative herbal drug that is repellent to sandflies. However, the clinical, laboratory, and radiographic findings clearly show that the Neem oil spray formulation used in this case report was not an effective means of CanL prevention. There is no clinical evidence in support of Neem oil-based products for the protection of dogs against CanL transmission. As Neem oil has previously been shown to be somewhat volatile, this case report suggests that even though it is a very effective repellent against sandflies, in practice, its effect on the dogs’ coat was only short-lived.
El uso del WhatsApp y el desempeño docente a nivel primario en el distrito de Ocoña, 2022
Authors: Puicaño Camavilca Ana Luz
Published: August 2022

La investigación establece al uso del WhatsApp como un elemento clave en el desempeño docente. El objetivo fue relacionar ambas variables a través de un estudio correlacional. En el caso, para el uso del WhatsApp se usó un cuestionario de un total de 20 preguntas (5 por cada dimensión de la variable) y así de igual forma, para la variable desempeño docente aplicándose ambos cuestionarios a una muestra de 24 docentes correspondientes a 6 escuelas rurales del distrito de Ocaña. Adicionalmente, se evidenció una asociación significativa entre el uso del WhatsApp y el desempeñó docente obteniéndose un valor del coeficiente de determinación de 0.6808. En definitiva, al usar el aplicativo WhatsApp para el intercambio de sus materiales educativos los docentes en las diferentes áreas de conocimiento afianzan su labor en los centros educativos que prestan servicio.
Los Señores de la devastación. Violencia ritualizada en las deidades guerreras e inframundanas del Occidente de México durante el Posclásico (900-1521 d. C.)
Authors: González Rizo Erick
Published: August 2022

El culto a dioses de la guerra en el Occidente ha sido objeto de estudio anteriormente, en especial en Michoacán. En el Occidente no tarasco; es decir, los estados de Jalisco, Colima, Nayarit, no se ha investigado a fondo el tema, por falta de fuentes escritas al respecto. Sin embargo, la evidencia iconográfica disponible en el registro arqueológico regional permite inferir la presencia de cultos bélicos en la región, muy extendidos durante el Posclásico (900-1521 d. C.). El fenómeno de la guerra no era exclusivo de este periodo, y hay evidencia arqueológica de ello en figurillas desde el Formativo, pero es durante este periodo tardío cuando se extienden las representaciones religiosas asociadas a la guerra y el militarismo, en especial en áreas con presencia de la Red Aztatlán. Se propone que los cultos guerreros regionales compartían unlenguaje simbólico común como parte de la creciente integración interregional del sistema-mundo mesoamericano.
El vocabulario político para los pueblos indígenas del Chaco y la Pampa durante el período colonial: nación y parcialidad
Authors: Lucaioli Carina P. , Nacuzzi Lidia R.
Published: August 2022

En las fuentes documentales del período colonial es muy habitual que aparezcan las palabras nación, parcialidad, parcialidades o parciales vinculadas a los grupos indígenas. Como muchos otros vocablos de las fuentes, su uso se ha extendido -sin demasiado análisis- a los escritos académicos desde los iniciosde la disciplina antropológica argentina. Una mirada más particularizada en las situaciones y contextos en los que se usan y registran estos vocablos -en las fronteras, en las salas capitulares, en los escritos de los jesuitas y en la producción de los etnohistoriadores pioneros- nos permite reconocer diversos matices de significación. Sostenemos que una reflexión sobre esos contextos y matices podría echar luz sobre los imaginarios de la agencia colonial acerca de la organización política de los pueblos indígenas del pasado y, a la vez, iluminar las formas en que los términos perduraron como vocabulario técnico-político en la producción académica.
Introducción al Dossier: "Cuando sea grande": algunas derivaciones de la obra de Martha Bechis
Authors: Cutrera María Laura , Morrone Ariel J.
Published: August 2022

La obra de Martha Bechis fue prolífica y abrevó en marcos teóricos diversos -teoría de las catástrofes, del caos o de los cambios discontinuos y del juego y del drama, la cibernética, el análisis del discurso y de las formaciones del estado- y reflexionó permanentemente  sobre la etnohistoria de la Panaraucanía. Su centralidad en el campo disciplinar trascendió sus contribuciones teóricas, históricas o analíticas pues tenía el don de escribir con sencillez, haciendo que nociones o conceptos complejos resultaran fáciles de comprender, por lo que sus trabajos suelen ser disparadores inagotables de ideas. Además cabe destacar otro aspecto que consideramos fundamental en el crecimiento del campo disciplinar del que fue pionera: su enorme generosidad, ya que dedicó buena parte de su tiempo, paciencia y amabilidad a formar discípulos que hoy integran ese campo, de ahí la motivación para la preparación y publicación de este dossier.
Las disputas por las memorias de la conquista: la crónica de Fernando de Alva Ixtlilxóchitl
Authors: Battcock Clementina , Zavala Jhonnatan
Published: August 2022

Las memorias de la conquista meosamericana fueron registradas en manuscritos conocidos como el corpus de las crónicas de tradición indígena que responden a un complejo de significados temporales y espaciales, así como a las preocupaciones de sus autores sobre las culturas prehispánicas y sus alianzas. En este artículo estudiamos cómo el Compendio histórico de los reyes de Tetzcoco, de Fernando de Alva Ixtlilxóchitl, representa la guerra contra Tenochtitlan y se ocupa de la construcción simbólica de los gobernantes de Tetzcoco. Esta crónica, compuesta por trece relaciones que exploran la historia de la población acolhua en el este de la cuenca de México, representa la intención del autor de persistir en el reconocimiento de su posición social como descendiente de los más importantes aliados del ejército dirigido por Hernán Cortés, versión que confronta la hegemonía de la presencia tenochca en la reorganización del gobierno virreinal español.
Advances in the Emerging Gradient Designs of Li Metal Hosts
Authors: Guan Wanqing , Hu Xiaoqi , Liu Yuhang , Sun Jinmeng , He Chen , Du Zhuzhu , Bi Jingxuan , Wang Ke , Ai Wei
Published: August 2022

Developing host has been recognized a potential countermeasure to circumvent the intrinsic drawbacks of Li metal anode (LMA), such as uncontrolled dendrite growth, unstable solid electrolyte interface, and infinite volume fluctuations. To realize proper Li accommodation, particularly bottom-up deposition of Li metal, gradient designs of host materials including lithiophilicity and/or conductivity have attracted a great deal of attention in recent years. However, a critical and specialized review on this quickly evolving topic is still absent. In this review, we attempt to comprehensively summarize and update the related advances in guiding Li nucleation and deposition. First, the fundamentals regarding Li deposition are discussed, with particular attention to the gradient design principles of host materials. Correspondingly, the progress of creating different gradients in terms of lithiophilicity, conductivity, and their hybrid is systematically reviewed. Finally, future challenges and perspective on the gradient design of advanced hosts towards practical LMAs are provided, which would provide a useful guidance for future studies.
Comparing Naltrexone and Metformin Pretreatment for Inducing Ovulation in Patients With Polycystic Ovary Syndrome in Intrauterine Insemination Cycles
Authors: Zarei Afsun , Namavar Jahromi Bahia , Madadi Gooya , Alborzi Mahshid , Bakhshaei Pardis
Published: August 2022

Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women. Hyperinsulinemia and insulin resistance are normally observed in PCOS patients and metformin is used to treat this disease. The evidence indicates that the opioid system plays a role in the pathogenesis of the PCOS. Based on the above-mentioned explanation, the present study evaluated the role of opioid antagonist (naltrexone) in PCOS-induced infertility compared to metformin. Materials and Methods: Totally, 120 patients afflicted with PCOS were assigned to three groups based on Rotterdam diagnostic criteria, with a body mass index (BMI) of 25-30 kg/m2 . The first group received naltrexone (50 mg/d) for 8 weeks. In addition, the second group were injected with metformin 1000 and then 1500 mg/d for the first and seventh weeks, respectively. Finally, the third group entered the intrauterine insemination (IUI) without prior therapeutic treatment. Then, the groups were compared in terms of the amount of estradiol produced per day of human chorionic gonadotropin injection and the total amount of gonadotropin needed, the number and size of the adult follicles, the number of days of taking the drug, and incidence of pregnancy-induced abo Results: Based on the results, the mean of infertility duration was not significant among the three groups (P=0.782). Further, the mean fasting insulin level between the metformin and control groups represented a significant difference (P=0.045). The average number of days to trigger patients in the 3 groups was not significant (P=0.346). Although the average number of follicles between metformin and naltrexone groups was not significant, it was higher in the naltrexone group. Finally, the average BMI of the naltrexone group after the treatment was lower compared to before treatment (P≤ 0.001). Conclusions: In general, the number of receiving days and the dose of the drug in the naltrexone group was lower compared to the metformin group. Furthermore, the number of mature follicles in both ovaries and the serum estradiol level in the naltrexone group was higher compared to the metformin group.
The Impact of the Structures of Planned Behavior Theory on Social Vitality of the Participants in Sports Aactivities
Authors: Askari Ahmadreza , Mohammadi Hamid , Zahedi Hamid , Shahnazi Hosein
Published: August 2022

Background. Happiness and vitality are among the essential spiritual and psychological needs of human beings. The main purpose of this study was to present a model of participation in sports activities with the level of social vitality and the moderating role of awareness based on the theory of planned behavior. Methods. In terms of methodology, the presnt study was a descriptive correlational study which adopted survey method for data collection. The present study’s population consisted of 120,000 males and females who participanted in group and individual sports activities and introduced by Municipality of Isfahan. A total of 384 participants including 247 females with an average age of 42±14.1 and 137 males with an average age of 46±10.66 were selected through stratified random sampling as our final sample. In order to collect data, the questionnaires of Oxford Argil Happiness (OHI) (2001) and Planned Behavior of Karimi et al. (2012) were used. Correlation coefficient, regression and structural equations were conducted through using SPSS and Amos softwares version 22 for data analysis. Results. The results showed that there was a significant positive relationship between willingness to do work and planned behavior of participation in sports activities, planned behavior of participation in sports activities and social vitality (p ≤0.05). Conclusion. It can be concluded hat by informing people of the beneficial effects of sports, it is possible to plan to establish people's participatory behavior in sports activities and consequently to to promote and maintain social happiness and vitality of people.
An investigation to the Physical Activity of Amateur Athletes during the Covid-19 Quarantine
Authors: Hamidi Talieh , Moradi Lida , Doroudian Aliasghar
Published: August 2022

Background. Given the current prevalence of COVID-19, the World Health Organization has ordered the implementation of health protocols and social distancing, as well as home quarantine as a way to control and manage the disease. Athletes' physical activity has been affected due to quarantine conditions, so this research was done to evaluate the physical activity of amateur athletes of Tehran National Gas Company in an attempt to provide a solution to maintain physical fitness. Methods.This study was a descriptive-survey research and the data collection tool utilized in this study was a researcher-made questionnaire consisting of 15 questions. The validity and reliability of the questionnaire were checked by experts and provided online questionnaire by the google form software and was available to individuals. The variables examined in the questionnaire were: current status of athletes 'physical fitness, relationship with the coach, place of residence, physical activity at home, athletes' feelings, training programs, level of family support for Athletes' sports activity, number and duration of training sessions, training intensity, and diet. The statistical population of this study was 100 people. The sample size was determined based on Morgan table, and 70 people were finally selected through easy sampling method and entered the study. Results. The results showed that most athletes were in the age range of 51-60 years. Most of the participants were active in the field of mountaineering. The majority of participants in the study had moderate physical fitness compared to the pre-quarantine period. Conclusion. According to the findings of this study, most athletes in this study had a moderate level of physical fitness. The study suggests that we increase the intensity of physical activities under supervision of coaches to maintain the fitness and increase the health and immunity.
Assessing the Compliance of Emergency Department of Hospital Performance with Clinical Guidelines: A Case Study
Authors: Azizzadeh mina , Ali Jannati , farzad rahmani , Daniz nagibi , Arezoo Abdi , kavoos shahsavarinia , JavanBiparva Akbar
Published: August 2022

Background. Clinical guidelines are texts developed to assist both physicians and patients in deciding on the most appropriate health care. This study evaluated the compliance of emergency performance with clinical guidelines at Sina Medical Training Center in Tabriz. Methods. This descriptive-analytical study was conducted on a case study at Sina Hospital under the supervision of Tabriz University of Medical Sciences. In the first stage, as a research tool, a checklist, approved in terms of validity and reliability, was set up to evaluate clinical guidelines. The second phase of this study was cross-sectional, conducted in a period of one month. All medical records of people referring to level 1 and 2 triage were reviewed based on the checklist and the data were entered into SPSS software, and since the normality of the data was confirmed, descriptive statistics and parametric tests (t-test and ANOVA) were used to analyze the data. Results. Considering the mean (1.72 ± 0.097) in this study, the adherence to clinical guidelines seems to be higher than average. The results also showed that there was no significant relationship between any of the demographic variables and the mean score of total compliance with the guidelines (P-value> 0.05). However, among other variables, a significant relationship was found between the place of the patient's visit as well as the type and time of patient assignment on the one hand and the average score of total compliance with the guidelines (P-value<0.05). With regard to the results of the regression test, patient’s place of visit was the only appropriate variable to predict the average of the total observance of emergency clinical guidelines (P-value<0.05). Conclusion. Considering the effect of influential variables such as location of the patient's visit, the time and type of patient assignment on the observance of the guidelines and the increasing improvement of the situation of these variables, the average observance of clinical guidelines can be improved further
Elements of Life of the Pandvar People in the Novel Korkai
Authors: P Johnson
Published: July 2022

Joe D. Cruz titled the novel Korkai, which travels through time more than a century. Korkai is an ancient port city ruled by the Early Pandyan Kingdom. It tells the long history of the Pandavas of Tuticorin. It is also a great resource to learn about the life of the marine fisher folk. This book, which accurately and artistically explains the changes brought about in the Bharatava society by the domination of foreigners, the arrival of Christianity, the liberation struggles, the changes that took place in independent India, and the arrival of modernity, is also a document that includes all the elements of a race's identity, culture, life, and history.  The events of the novel begin in 1914 and conclude in the year 2000. During this period, over two hundred Pandavar social men of Korkai came and went over four generations. The story is shaped by the subtle depiction of various events and different faces of people, as well as the astonishing spheres of change. This novel tells the stories of three generations of thirty thousand families through the language of the coast as a beautiful fiction about the changes in the lives of the people who own the woven land after European arrival. It starts with the death of the Pandava community leader and unfolds before us countless scenes before the flood of eighty-six years and ends with the death of the character Philip. The novel not only talks about the people but also the social, economic, and cultural changes that took place during these times. After the Portuguese and the British left the country and the native government came, the ‘Korkai’ novel is an excellent source to explore how the Pandava community that lived in Korkai established itself and cane beyond the flood of time. The purpose of this article is to identify the richness of the woven land, the pride, the valor, characteristics, beliefs, elements of worship, and the activities that hinder the development and progress of the people of the maritime people.
Realism in the Poems of A.S.M. Muniandi
Authors: P Vinthiya Gowri
Published: July 2022

Literature is a life experience. Modern Tamil poetry inspires the thought of writing freely. Tamil poetry is broadly divided into two types: classical (i.e., Marabu Kavithai) and modern (i.e., Puthu Kavithai). Modern poetry has freed itself from the shackles of grammar. It has a wide range of songs. The definitions of poetry are new. He realised that poetry of experience, the poetry of longing, the poetry of longing, the poetry of anger, poetry of hope, the poetry of wisdom, and Tamil poetry will come, and he knows life and sings in Tamil. He has written a wonderful poem saying that God and poetry are one. He has created poetry, understanding that in modern times, there is more falsehood and less truth in man. The poet has established through his poems that realism is the aesthetic of modern times. In the poem, the poet's imagination can realize the promise of the candidate. He emphasises that those who want to make a career in life should first know themselves. Prayer is the highest, but that alone does not make a man live. He says, "Charity is needed and gives importance to actions with humanity." In his new poem, thinking of Buddha, he has created the life of people in Kaliyuga as it is. Through poetry, he criticises the people who live as uncivilised people because of the TV craze. While voicing support for religious harmony and world peace, it highlights the violence happening in the country. The aim of the article is to attempt to express the feelings and the community, which is emphasised in Muniandi's poems. The uniqueness of the poet is that he not only praises the height of love but also sings about the other side of love.
PLANNED REPLACEMENT THERAPY OF INTRAVENOUS IMMUNOGLOBULIN IN CHILDREN WITH NON-HODGEN LYMPHOMA IN THE CHELYABINSK CHILDREN'S ONCOLOGICAL CENTER
Authors: Спичак И.И. , Коваленко С.Г. , Топоркова Д.И. , Зуб Н.В. , Теплых Е.В.
Published: August 2022

Неходжкинские лимфомы (НХЛ) представляют собой гетерогенную группу злокачественных опухолей, происходящих из лимфоидной ткани, с широким спектром клинических, морфоиммунологических и молекулярногенетических проявлений, неоднозначным течением и прогнозом 3. В общероссийской структуре детской заболеваемости злокачественными новообразованиями, как и в Челябинской области, НХЛ стабильно занимают третье место, уступая только лейкозам и опухолям центральной нервной системы
Role of Investment Opportunity Set (IOS) in Moderating the Influence of Company Size, Activity, and Profitability on Capital Structure in Multi-Industry Sector Companies for the Period 2015-2019
Authors: Nainggolan Christine Dewi , Susanti Elly , Azwar Khairul
Published: July 2022

Growing business competition expects companies to pay more attention to ensuring capital accessibility. Fulfillment of capital needs can be obtained both internally and externally from the company. The capital structure is important for every company because it directly affects the financial position of the company, therefore the financial manager must understand the factors that affect the capital structure to maximize the prosperity of the company's shareholders. The purpose of this research is to analyze and explain the influence of firm size, activity, and profitability on capital structure moderated by investment opportunity set in multi-industry sector companies. The population in this research is a multi-industry sector company listed on the Indonesia Stock Exchange, with a research period of 2015 to 2019. The selection of samples in this research used the purposive sampling method. The data analysis techniques used in this research are descriptive statistical analysis, classical assumption test, hypothesis test, and residual test for regression moderation analysis on SPSS. The results of this study showed that firm size and activity had a positive and significant effect, while profitability had a significant effect on the capital structure, Investment opportunity sets (IOS) play a role in moderating the influence of firm size, activity, and profitability on capital structures. The practical implications on this study, for investors who want to invest in the company, can consider the magnitude of the investment opportunites that the company has. Companies that have high investment opportunities it means companies have the opportunity to grow which has an impact on investors’ profits in the future. Companies with high market capitalization are considered good by investors because they can provide good stock returns through high stock prices. For companies, it helps managers in determining optimal capital structure policies in maximizing the company’s profit and creating well-being for investors.
GENERACIÓN DE RAÍCES Y PLÁNTULAS TRANSGÉNICAS DE TORONJA Y LIMA DULCE MEDIANTE EL USO DE Agrobacterium rhizogenes
Authors: Serna-Pérez Arturo , Molphe-Balch Eugenio Pérez
Published: July 2022

La transformación genética es una técnica atractiva para el mejoramiento de los cítricos ya que evita los largos periodos juveniles y permite introducir nuevas características a un cultivar sin alterar los rasgos existentes. Un paso indispensable para aplicar esta tecnología de mejoramiento de los cítricos, es el desarrollo de sistemas eficientes de transformación genética que confieran ventajas agronómicas. En este reporte se presenta el desarrollo de sistemas de transformación genética basados en Agrobacterium rhizogenes para la toronja (Citrus paradisi cvs. Duncan y Rio Red) y la lima dulce (Citrus limmettioides). Primero se generaron raíces transformadas por medio del cocultivo de segmentos de tallo obtenidos de plántulas germinadas in vitro con A. rhizogenes cepa A4, que contenía el plásmido tipo silvestre pRiA4 y el vector binario pESC4 con los genes nos-nptII y cab-gus. La mayor eficiencia de transformación, medida como el porcentaje de explantes que formaron raíces, se obtuvo en la toronja Duncan (78 %), seguida por la toronja Rio Red (68 %) y la lima dulce (60 %). Se detectó actividad de GUS en 89, 92 y 76 % de las raíces generadas en toronja Duncan, toronja Rio Red y lima dulce, respectivamente. Luego se regeneraron brotes adventicios a través de organogénesis en segmentos de raíz transformada cultivados en medios con citocininas o con citocininas y auxinas; tales brotes adventicios se generaron en 24 % de los casos en toronja Duncan, en 14 % de los de toronja Rio Red y en 8 % de los de lima dulce. Los análisis GUS confirmaron que las plantas regeneradas conservaron la actividad de este gen introducido a las raíces transformadas. Los resultados mostraron que el sistema de transformación establecido introdujo exitosamente ADN foráneo a la toronja y a la lima dulce, y que puede ser útil para la generación de plantas que expresen genes de interés agronómico.
ANALISIS HASIL PENGUJIAN DAN KALIBRASI PARAMETER BLOOD PRESSURE PADA ALAT KESEHATAN BLOOD PRESSURE MONITOR
Authors: Hadziqoh Nur , Pertiwi Yeni , Mulyadi Romi
Published: August 2022

Pengujian dan kalibrasi alat kesehatan merupakan salah satu usaha untuk menjamin mutu kelaikan alat kesehatan. Telah dilakukan pengujian dan kalibrasi pada alat kesehatan Blood Pressure Monitor (BPM) yang berada pada ruang IGD di salah satu rumah sakit. Pada artikel ini akan dijelaskan bagaimana tahapan dalam melakukan pengujian dan kalibrasi alat BPM sampai didapatkan hasil laik/tidak laiknya alat tersebut. Ini bertujuan untuk memberikan pengetahuan dan penyadaran kepada tenaga kesehatan sebagai pengguna alat dan pasien terhadap pelaksanaan dan pentingnya pengujian dan kalibrasi alat kesehatan. Metode yang digunakan adalah Metode Kerja dari Kemenkes RI tahun 2018. Parameter pengujian terdiri dari uji pemeriksaan fisik dan fungsi alat serta uji kinerja Blood Pressure pada titik pengukuran tekanan systole 60, 80, 100, 120, 150, 200 mmHg dan titik tekanan diastolik 30, 50, 65, 80, 100, dan 150 mmHg. Hasil uji pemeriksaan fisik dan fungsi 100% baik. Hasil uji kinerja blood pressure 94% lulus uji dengan nilai ketidakpastian pengukuran di bawah ambang batas toleransi (± 5 mmHg). Titik pengukuran tekanan dyastole 150 mmHg memiliki nilai ketidakpastian pengukuran melewati ambang batas toleransi sehingga pada titik tekanan tersebut tidak lulus uji. Dengan demikian alat kesehatan BPM tersebut dinyatakan laik untuk digunakan.
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN TINDAKAN 3M PLUS PADA IBU RUMAH TANGGA DI KELURAHAN TANJUNG RANCING TAHUN 2022
Authors: Alya Danisa Devara , Ridwan  , Anwar Khairil
Published: August 2022

Upaya memberantas jentik nyamuk di wilayah kerja Puskesmas  Kutaraya pada tahun 2020 memiliki capaian sebesar 66% dan di wilayah kerja Puskesmas Kutaraya, terdapat satu Kelurahan terendah memberantas jentik nyamuk yaitu Kelurahan Tanjung Rancing baru mencapai 58%. Indikator tersebut tidak berhasil karena target harus dicapai untuk indikator memberantas jentik nyamuk adalah 95% Sesuai dengan peraturan menteri kesehatan nomor 50 tahun 2017. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dan sikap dengan tindakan 3m plus pada ibu rumah tangga di Kelurahan Tanjung Rancing. Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional study. Sampel pada penelitian ini adalah 100 orang ibu rumah tangga.Teknik pengambilan sampel adalah Proportionate Stratified Random Sampling. Analisis data yaitu analisa univariat dan analisa bivariat yang menggunakan Chi Square. Dari 100 responden ibu rumah tangga terdapat 59% memiliki pengetahuan baik, 51% memiliki sikap negatif, dan 53% memiliki tindakan kurang baik. Hasil uji statistik Chi-Square diperoleh nilai p<0,05 (p=0,001) artinya ada hubungan antara pengetahuan dengan tindakan 3m plus serta nilai p<0,05 (p=0,017) artinya ada hubungan antara sikap dengan tindakan 3m plus maka dapat disimpulkan bahwa ada hubungan yang signifikan antara pengetahuan dan sikap dengan tindakan 3m plus pada ibu rumah tangga di Kelurahan Tanjung Rancing.
Current challenges of nursing care in Latin America
Authors: Lucas-Choez Mercedes María , Alonso-Muñiz Gina Rosa , Alcázar-Pichucho Mercedes Tania , Jaime-Hernández Noralma Katherine
Published: August 2022

The general objective of this research was to analyze the current challenges of nursing care in Latin America. The research work was carried out from the quantitative approach, by means of exploration, collection and critical analysis of documents and bibliographic references. The interpretation techniques of the inquiry were based on the content analysis of the information collected, which allowed the formulation of results. Supported by the analytical-synthetic method, it consisted of mentally decomposing the system studied into several elements to arrive at new knowledge. As a result, it is indicated that nursing faces great challenges in Latin America, as a result of the changes that are occurring in the world, the performance of professional practice requires greater academic preparation. It is concluded that the change of thinking about social problems, the contextualized or situated education in the formation of nursing professionals is one of the answers that lead to future changes.
La seguridad de los pacientes en cuidados intensivos
Authors: Pico-Macías Anggie Evelyn , Mesías-Mercado Emma Marisela , Mendoza-Pico Valeria Valentina , Maigual Cabrera Diana Yurani
Published: August 2022

El objetivo general de la presente investigación fue analizar la seguridad de los pacientes en cuidados intensivos. Se desarrolló  desde el enfoque cuantitativo, a través de la búsqueda, recolección y análisis crítico documental, referencial bibliográfico y trabajos científicos arbitrados, desde un diseño bibliográfico de tipo documental, los investigadores organizaron y planificaron el proceso de investigación donde la población de estudio lo conformó principalmente documentos escritos, tesis, revistas arbitradas para indagar los escritos con el propósito de escrutarlos y construir conclusiones generando nuevos conocimientos. Para la técnica de interpretación de la indagación, se consideró el análisis de contenido de la información recopilada, lo que permitió la formulación de resultados. Se concluye, que es necesario establecer mediante la gestión de salud, estrategias y políticas para fortalecer la seguridad de los enfermos que acuden a los centro de salud y en especial a los ingresos a UCI (Unidad de cuidados intensivos), pacientes graves.
A strategy based on music activities to promote motivation in a public school
Authors: Serrano-Espinoza Julio Javier , Argudo-Serrano Juanita Catalina
Published: August 2022

One of the biggest challenges educators deal with nowadays is to find creative ways This study used music and songs as a motivational tool in the process of learning English as a foreign language (EFL). This study used a descriptive cross-sectional design. To collect data; a questionnaire was conducted to assess whether the use of musical activities in the English as a foreign language (EFL) classroom affects students' motivation to acquire vocabulary. The findings of this research are intended to be an open door for those educators who are looking for ways to motivate students through the use of music activities and could provide some practical suggestions for integrating music lesson activities into the EFL teaching area.
La retribución económica por el uso del agua en la gran minería del Perú
Authors: Velásquez-Velásquez Sergio Daniel
Published: August 2022

La investigación busca establecer la relación entre el valor económico del agua y la retribución económica por el uso del agua en la gran minería en el Perú durante el periodo 2015-2019. La investigación fue de nivel descriptiva, explicativa y correlacional. En los resultados se halla la incidencia del valor de la retribución económica por el agua para uso minero en las utilidades de la gran minería del cobre y del oro por metro cubico de agua, se concluye que existe una débil relación entre el valor económico del agua y la retribución económica por el uso del agua con fines mineros. El valor de la retribución económica por el uso del agua con fines mineros tiene un desfase en una proporción de 1 a 10 con respecto al valor económico del agua, lo cual no es adecuado para el establecimiento de una política eficiente de los recursos hídricos.
Medidas de bioseguridad en el contagio de tuberculosis pulmonar en el personal de salud
Authors: Zegarra-Sánchez Cynthia Eugenia
Published: August 2022

El objetivo se basó en determinar la relación entre las Medidas de Bioseguridad del personal y el nivel de contagio de la TBC en el Hospital Hipólito Nacional Unanue, 2021. El diseño fue de tipo observacional, descriptivo, transversal y retrospectivo. Existe una relación significativa entre las Medidas de Bioseguridad y el nivel de contagio de la TBC en el Hospital Hipólito Nacional Unanue, 2021.  De los 264, profesionales consultados la gran mayoría conoce y aplica correctamente las medidas de bioseguridad en las distintas áreas evaluadas, contribuyendo de esta manera a reducir significativamente la curva de contagios en pacientes TBC en el mencionado centro de salud, en comparación con años anteriores, estadísticamente para el momento de la investigación se atendieron 60 % de casos Nuevos de TBC, 20% Continuadores y 20 % resistente.
La investigación y propiedad intelectual en la transferencia del conocimiento en estudiantes de Educación Superior
Authors: Esteves-Fajardo Zila Isabel , Albán-Sánchez José Dionel , Casco-de-Navarrete Elena , Muñoz-Ortiz Willian Wistor
Published: August 2022

El objetivo general del presente trabajo fue analizar la investigación y propiedad intelectual en la transferencia del conocimiento en estudiantes de Educación Superior. Para el desarrollo, los investigadores analizaron bajo el paradigma cuantitativo, así mismo se enmarcó desde un diseño documental, ya que se analiza y estudia una serie de datos de fuentes impresas, electrónicas y audiovisuales, entre otras referencias bibliográficas que apoyan esta indagación documental. Así mismo, la población de estudio, está conformada por tesis, revistas, trabajos arbitrados, estableciendo el cuerpo teórico. Se plantea además el método analítico-sintético por medio del cual, se descompone un todo en partes extrayendo cualidades, componentes, relaciones y más para posteriormente unir las partes analizadas. Se concluye que es significativo reflexionar sobre la generación de conocimientos en el espacio universitario, ya que es una constante que a través del ejercicio de las funciones académicas (docencia-investigación-extensión-vinculación), lo que beneficiaria el resguardo intelectual generando beneficios académicos.
Factores de riesgo para el fracaso de los minitornillos de ortodoncia. Revisión de la literatura
Authors: Reyes-Nagua Sofia Lourdes , Campoverde-Torres Cristian Hernán , Calderon-Barzallo Mario Leonardo
Published: August 2022

El objetivo fue describir los factores predisponentes al fracaso de los minitornillos de ortodoncia, para lo cual se efectuó una revisión de la literatura de tipo investigación secundaria, descriptiva. Finalmente se determinó que hubo heterogeneidad metodológica en los estudios de la revisión por lo que sus resultados deben ser asumidos con prudencia. Se recomienda realizar ensayos aleatorios controlados que muestre mejor calidad metodológica y mejores niveles de evidencia sobre los factores que predisponen al fracaso de los minitornillos de ortodoncia, sobre todo los factores extrínsecos para controlarlos y optimizar así la práctica clínica del ortodoncista y proporcionar mayor satisfacción al paciente.
Calidad educativa en escuelas unidocentes: Perspectivas docentes
Authors: Condo-Arévalo Carla Johana , Álvarez-Santana Carmita Leonor , Castro-Salazar Ana Zulema
Published: August 2022

Este artículo presenta la investigación de las perspectivas docentes sobre la calidad educativa en escuelas unidocentes de la provincia de Morona Santiago en el Cantón Tiwintza, en un enfoque de análisis cuantitativo y cualitativo, a través de las técnicas de cuestionario y entrevista, se concluye que la multifunción, la falta de recursos, generación de políticas destinadas a escuelas unidocentes y el acceso a las instituciones ocasionan que no exista calidad educativa, además, las escuelas unidocentes no han sido una prioridad para el estado y líderes educativos, finalmente en base a los resultados se propone un diseño AAAM: ambiente de Aula, aprendizaje activo, autoevaluación y mejora.
La atención de enfermería en el embarazo de alto riesgo
Authors: Alcázar-Pincay Angie Celeste , Bravo-Parrales Juber Alfonso , Acebo-Cerón Leslie Katherin , Tovar-Minchala Domenica Valentina
Published: August 2022

El articulo tiene por objetivo analizar la atención de enfermería en el embarazo de alto riesgo. Se trabajó en base a un tipo de investigación descriptiva documental con diseño bibliográfico, en una población de 23 artículos tomados de la base de datos PubMed. El principal tema que deben abordar y manejar las enfermeras, es el temor de las embarazadas de alto riesgo, por cuanto les ayuda a prepararse emocionalmente para un parto sin mayores complicaciones, teniéndose en cuenta factores como la edad, hipertensión, entre los que mayor afección podrían ocasionar, de ese modo, se considera que las enfermeras preparadas como parteras pueden asumir el trabajo de parto en ausencia de médicos, sobre todo cuando se trata de emergencias.