bluuebunny/crossref_metadata_2025 huggingface dataset:
Variational criterion of evenness
Authors: Volovik A. V.
Published: March 2023

Abstract. Aim. The author has developed a criterion to test the hypothesis of a uniform distribution for random variable observations in small samples. The criterion is built by using sample observations to construct a variation series in ascending order and dividing each previous term of this series by the extreme term, then discarding it. The resulting new variation series is processed similarly until there is only one quotient left that is the criterion value.

Methods. The paper uses methods of the probability theory and mathematical statistics.

Results. The suggested criterion is sufficiently efficient for distinguishing between samples of minimal size for statistically similar hypotheses, such as the hypothesis of a uniform distribution law and the hypothesis of a beta distribution of the first kind.

Conclusions. The approach suggested in the paper makes it quite simple to implement the sequential analysisprocedure (detection of a “dissonance” in a process). Such a procedure allows detecting a “dissonance” (deviation of the distribution of observations from the uniform law) with a practically sufficient rate.
Метакогнитивные навыки и выраженность учебного стресса современных студентов в связи с особенностями их эмоциональной сферы
Authors: Гусева Юлия В. , Сылка Надежда В. , Денисова Екатерина Г.
Published: March 2023

В данном исследовании авторы освещают связь метакогнитивных навыков и выраженности учебного стресса современных студентов с особенностями их эмоциональной сферы. Актуальность исследования заключается в повышении общего уровня стресса в изменении общественно-политических условий и в распространении данной проблемы среди субъектов образовательной деятельности, а также в слабом изучении связи метакогниций и особенностей эмоциональной регуляции в условиях учебного стресса среди студентов. Новизна исследования заключается в более системном взгляде на проблему учебного стресса студентов и способов его регуляции и самоорганизации с помощью метакогнитивных навыков. Исследование проводилось с помощью теоретического анализа литературы; авторской анкеты самооценки метакогнитивного поведения «Метакогнитивные навыки в структуре учебно-профессиональной деятельности» (Денисова, 2022); метода тестирования с помощью следующих методик: методика «шкала дифференциальных эмоций» (ШДЭ, адаптация Леоновой А.В. и Капицы М.С., 2003), опросник метакогнитивной включенности в деятельность (Г. Шроу, Р. Деннисон, адаптация А.В.Карпова, 1994), шкала самооценки метакогнитивного поведения (Д. Лакоста, адаптация А. В. Карпова, 1998) и опросник «когнитивная регуляция эмоций» Н. Гарнефски и В. Крайг (адаптация О. Л. Писаревой, 2007); метода математической статистики с использованием критерия Шапиро-Уилка и коэффициента ранговой корреляции Спирмана на выборке обучающихся высших образовательных учреждений Ростовской области в количестве 317 человек в возрасте от 17 до 45 лет. В результате выявлены достоверные связи между метакогнитивными навыками и интегральными индексами эмоций с показателями стресса, между когнитивной регуляцией эмоций и сформированностью метакогнитивных навыков. В заключении делается вывод о том, что метакогнитивные навыки способствуют более успешной регуляции учебного стресса и адаптации в изменяющихся общественно-политических и экономических условиях.
Induced Pluripotent Stem Cells in the Era of Precise Genome Editing
Authors: Punetha Meeti , Saini Sheetal , Chaudhary Suman , Yadav Prem Singh , Whitworth Kristin , Green Jonathan , Kumar Dharmendra , Kues Wilfried A.
Published: March 2023

Genome editing has enhanced our ability to understand the role of genetics in a number of
diseases by facilitating the development of more precise cellular and animal models to study pathophysiological
processes. These advances have shown extraordinary promise in a multitude of areas, from basic
research to applied bioengineering and biomedical research. Induced pluripotent stem cells (iPSCs) are
known for their high replicative capacity and are excellent targets for genetic manipulation as they can be
clonally expanded from a single cell without compromising their pluripotency. Clustered, regularly interspaced
short palindromic repeats (CRISPR) and CRISPR/Cas RNA-guided nucleases have rapidly become
the method of choice for gene editing due to their high specificity, simplicity, low cost, and versatility.
Coupling the cellular versatility of iPSCs differentiation with CRISPR/Cas9-mediated genome editing
technology can be an effective experimental technique for providing new insights into the therapeutic use
of this technology. However, before using these techniques for gene therapy, their therapeutic safety and
efficacy following models need to be assessed. In this review, we cover the remarkable progress that has
been made in the use of genome editing tools in iPSCs, their applications in disease research and gene
therapy as well as the hurdles that remain in the actual implementation of CRISPR/Cas systems.
World’s First Experience of the Low-Dose Radionuclide Inhalation Therapy in the
Treatment of COVID-19-Associated Viral Pneumonia: Phase 1/2 Clinical Trial
Authors: Shegay Peter , Leontyev Alexey , Baranovskii Denis , Davydov German , Poluektova Marina , Grivtsova Lyudmila , Petriev Vasily , Stepanenko Valeriy , Gulidov Igor , Krylov Valeriy , Osadchaya Svetlana , Petrov Vladimir , Sedova Maria , Vekilyan Mikhail , Krasilnikova Olga , Morozov Sergey , Ivanov Sergey , Klabukov Ilya , Kaprin Andrey
Published: March 2023

Objective:

Previously, low-dose radiation therapy was
used for pneumonia treatment. We aimed to investigate the safety
and effectiveness of carbon nanoparticles labeled with Technetium
isotope (99mTc) in a form of ultradispersed aerosol in combination
with standard COVID-19 therapy. The study was a randomized
phase 1 and phase 2 clinical trial of low-dose radionuclide inhalation
therapy for patients with COVID-19 related pneumonia.

Methods:

We enrolled 47 patients with confirmed COVID-19 infection
and early laboratory signs of cytokine storm and randomized
them into the Treatment and Control groups. We analyzed
blood parameters reflecting the COVID-19 severity and inflammatory
response.

Results:

Low-dose 99mTc-labeled inhalation showed a minimal
accumulation of radionuclide in lungs in healthy volunteers. We
observed no significant differences between the groups before
treatment in WBC-count, D-dimer, CRP, Ferritin or LDH levels.
We found that Ferritin and LDH levels significantly raised after the
7th day follow-up only in the Control group (p < 0.0001 and p =
0.0005, respectively), while mean values of the same indicators did
not change in patients in the Treatment group after the radionuclide
treatment. D-dimer values also lowered in the radionuclide treated
group, however, this effect was not statistically significant. Furthermore,
we observed a significant decrease in CD19+ cell counts
in patients of the radionuclide-treated group.

Conclusion:

Inhalation low-dose radionuclide therapy of 99mTc
aerosol affects the major prognostic indicators of COVID-19-
related pneumonia restraining inflammatory response. Overall, we
identified no evidence of major adverse events in the group receiving
radionuclide.
Modulatory Effects of Mangiferin Isolated from Aquilaria Plants on
Human Cytochrome P450 Enzyme (CYP) Activities In vitro and In silico
Studies
Authors: Pan Yan , Jagadish Premika , Tze Ung Yee , Ming Sharoen Lim Yu , Hon Lim Kuan , Siau Ee Jason Loo , Pung Yuh Fen , Sadeque Chowdhury Lamia Noushin , Tao Shang
Published: March 2023

Background:

Mangiferin has been identified as one of the major active constituents of Aquilaria
plants. It was reported to have several promising chemotherapeutic potentials. Our preliminary data
suggested that Aquilaria plant water extracts inhibited several cytochrome P450 (CYP) isoenzymes in
vitro.

Objective:

This study aimed to investigate the modulatory effects of mangiferin on six major drug metabolizing
CYP enzymes including CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP3A4, and CYP3A5.

Methods:

The enzyme activities were measured using fluorescence-based assays and enzyme kinetic such
as IC50 parameters and Ki values were calculated to evaluate inhibitory potencies and mechanisms. Moreover,
for potent inhibitions, molecular docking studies were carried out to explore potential interactions of
residues between mangiferin and CYP enzymes.

Results:

Our findings suggested that mangiferin could inhibit CYP2D6, CYP3A4, and CYP3A5 in vitro
with IC50 values of 9.2, 8.7, and 4.3 μM, and Ki values of 3.8, 10.8, and 9.6 μM, in a non-competitive
inhibition pattern. Molecular docking studies using AutoDock 4.2 identified potential residues contained
in mangiferin that interacted with CYP2D6, CYP3A4, and CYP3A5, resulting in the observed inhibitory
effects.

Conclusion:

Mangiferin should be used carefully, in particular, with conventional drugs metabolized
mainly by CYP2D6, CYP3A4, and CYP3A5. Further in vivo studies are recommended to evaluate the
clinical relevance of these inhibitions.
Nanotechnology for Cancer Treatment: An Introduction
Authors: Mazahir Farhan , Pathak Anchal , Gupta Ujala , Yadav Awesh K.
Published: March 2023

Cancer is the leading cause of death worldwide. The treatment of cancer
remains a challenge for medical professionals. Although various options, like
chemotherapy, radiation, and surgery, are available to manage cancer, their use could
be limited due to serious adverse effects. Therefore, advancements are highly essential
to treat cancer properly. Nanotechnology provides new rays of hope for the effective
treatment of cancer. Nanotechnology-based drug delivery carriers (NCs), such as
nanoparticles, liposomes, dendrimers, polyplexes, and many more, offer treatment
strategies due to their ability to target cancer cells. As these NCs target cancer cells, the
exposure of other tissues to the drug is very less. Hence, these NCs exhibit fewer side
effects in comparison with standard anti-cancer drugs. Here, we try to summarize a
precise introduction of different NCs and their role in cancer therapy.
Analysis of integrated clean water services for west Bali region
Authors: Triadi I Nyoman Sedana , Yasa I Made Tapa , Mudhina Made , Andayani Ketut Wiwin , Sutapa I Ketut
Published: March 2023

The area of Jembrana Regency is 841.80 km2, has five sub-districts. The total population in 2021 is 281,289 people, covering the Melaya District 54,032 people, State District 85,349 people, Jembrana District 56,061 people, Mendoyo District 58,909 people, Pekutatan District 26,938 people. Gerokgak District is part of the western part of Bulelelng Regency. The population of Grokgak Subdistrict in 2021 is 86,421 people. The integration of clean water supply in the western part of Bali is very important, because the community is a collection of individuals who have socio-cultural, occupying different areas and environments, but have a common interest, for the fulfillment of water as a source of human life. Differences in interests in the use of water include, domestic and non-domestic interests, industry, irrigation and conservation. To find out the potential of Tukad Unda downstream in providing clean water, an analysis of its water The provision of clean water in the western part of Bali will be studied in this study, in line with efforts to improve clean water management in Jembrana Regency and Buleleng Regency. To determine the water balance in providing clean water, an analysis of water availability and water needs is carried out.
Zmiany infrastruktury społecznej w województwie mazowieckim w latach 2005–2020
Authors: Chmielewska Barbara
Published: March 2023

W artykule przedstawiono stan infrastruktury społecznej na obszarach wiejskich w województwie mazowieckim oraz zmiany jakie nastąpiły po akcesji Polski do Unii Europejskiej. Artykuł przedstawia badania identyfikacji obszarów, które mają utrudniony dostęp do podstawowych usług społecznych, jak m.in. do opieki zdrowotnej, pomocy społecznej, edukacji, kultury, cyfryzacji. Jest to badanie realizowane w zadaniu 3 pt. „Opracowanie idei Smart Villages Mazowsza”, w ramach przedsięwzięcia pn. „Wdrażanie koncepcji Smart Villages na terenie województwa mazowieckiego”, finansowanego przez Samorząd Województwa Mazowieckiego. W efekcie integracji Polski z UE nastąpił rozwój infrastruktury technicznej i społecznej na terenach wiejskich. Warunki życia na wsi stały się podobne do miejskich. Poprawa infrastruktury społecznej przyczyniła się do ograniczenia migracji ze wsi do miast, zwłaszcza ludzi młodych i zachowania żywotności na obszarach wiejskich. Przedstawiono ogólną charakterystykę obszarów wiejskich w województwie mazowieckim, sytuację demograficzną i na rynku pracy. Przyjęto następujące grupy wskaźników infrastruktury społecznej: ochrona zdrowia, usługi opiekuńcze, edukacja, kultura. Analizą objęto lata: 2005–2020. W tym okresie na obszarach wiejskich w województwie mazowieckim nastąpiła poprawa infrastruktury społecznej. Na wsi wzrosła liczba przychodni lekarskich, domów pomocy społecznej, przedszkoli, instytucji kultury. Mimo to, nadal dostęp do usług społecznych na wsi jest bardziej utrudniony niż w mieście. Słowa kluczowe: obszary wiejskie, infrastruktura społeczna, województwo mazowieckie
On the issue of deformation and destruction of porous ceramics based on diatomite
Authors: Skvortsov A. A.  , Nikolaev V. K.  , Luk'yanov M. N.  , Chebeneva I. E.
Published: March 2023

The presented work is devoted to the study of deformation and destruction of porous ceramics based on diatomite. The dependences of the elastic modulus of the material on porosity were obtained by scanning electron microscopy, mechanical compression tests of samples and acoustic emission method: with a change in the porosity of the medium in the range of 20-60%, the value of the elastic modulus varied in the range from 240 to 50 MPa. It was also found that the tensile strength of the material's changes by ~10 MPa with a change in porosity. Keywords: porous ceramics, diatomite, modulus of elasticity, tensile strength, porosity, fracture mechanics.
Characterization of Self-reported Improvements in Knowledge and Health Among Users of Flo Period Tracking App: Cross-sectional Survey
Authors: Zhaunova Liudmila , Bamford Ryan , Radovic Tara , Wickham Aidan , Peven Kimberly , Croft Jazz , Klepchukova Anna , Ponzo Sonia
Published: March 2023

Background

Research shows that poor knowledge and awareness of menstrual and pregnancy health among women are associated with adverse reproductive health and pregnancy outcomes. Menstrual cycle– and pregnancy-tracking mobile apps are promising tools for improving women’s awareness of and attitudes toward their reproductive health; however, there is little information about subscribers’ perceptions of app functionality and its impact on their knowledge and health.

Objective

This study aimed to explore knowledge and health improvements related to menstrual cycle and pregnancy, as well as improvements in general health among Flo app users. We also investigated what components of the Flo app were associated with the abovementioned improvements and evaluated whether those improvements differed based on education level, country of residence (low- and middle-income vs high-income countries), free or premium subscription to the app, short- or long-term use of the app, and frequency of use.

Methods

Flo subscribers who had been using the app for no less than 30 days, completed a web-based survey. A total of 2212 complete survey responses were collected. The survey included demographic questions and questions about motivations guiding the use of the Flo app and which components of the app improved their knowledge and health, as well as to what extent.

Results

Most study participants reported improvements in menstrual cycle (1292/1452, 88.98%) and pregnancy (698/824, 84.7%) knowledge from Flo app use. Participants with higher levels of education and those from high-income countries reported using the app predominantly for getting pregnant (χ21=4.2, P=.04; χ21=52.3, P<.001, respectively) and pregnancy tracking (χ21=19.3, P<.001; χ21=20.9, P=.001, respectively). Participants with less education reported using the app to avoid pregnancy (χ21=4.2; P=.04) and to learn more about their body (χ21=10.8; P=.001) and sexual health (χ21=6.3; P=.01), while participants from low- and middle-income countries intended to mainly learn more about their sexual health (χ21=18.2; P<.001). Importantly, the intended use of the app across education levels and country income levels matched areas in which they had gained knowledge and achieved their health goals upon use of the Flo app. Period, fertile days, and ovulation predictions as well as symptom tracking were consistently the top 3 components in the app that helped users with their cycle knowledge and general health. Reading articles or watching videos helped with users' education regarding their pregnancy. Finally, the strongest improvements in knowledge and health were observed in premium, frequent, and long-term users.

Conclusions

This study suggests that menstrual health apps, such as Flo, could present revolutionary tools to promote consumer health education and empowerment on a global scale.
Participatory Surveillance for COVID-19 Trend Detection in Brazil: Cross-sectional Study
Authors: Wittwer Salome , Paolotti Daniela , Lichand Guilherme , Leal Neto Onicio
Published: March 2023

Background

The ongoing COVID-19 pandemic has emphasized the necessity of a well-functioning surveillance system to detect and mitigate disease outbreaks. Traditional surveillance (TS) usually relies on health care providers and generally suffers from reporting lags that prevent immediate response plans. Participatory surveillance (PS), an innovative digital approach whereby individuals voluntarily monitor and report on their own health status via web-based surveys, has emerged in the past decade to complement traditional data collection approaches.

Objective

This study compared novel PS data on COVID-19 infection rates across 9 Brazilian cities with official TS data to examine the opportunities and challenges of using PS data, and the potential advantages of combining the 2 approaches.

Methods

The TS data for Brazil are publicly accessible on GitHub. The PS data were collected through the Brazil Sem Corona platform, a Colab platform. To gather information on an individual’s health status, each participant was asked to fill out a daily questionnaire on symptoms and exposure in the Colab app.

Results

We found that high participation rates are key for PS data to adequately mirror TS infection rates. Where participation was high, we documented a significant trend correlation between lagged PS data and TS infection rates, suggesting that PS data could be used for early detection. In our data, forecasting models integrating both approaches increased accuracy up to 3% relative to a 14-day forecast model based exclusively on TS data. Furthermore, we showed that PS data captured a population that significantly differed from a traditional observation.

Conclusions

In the traditional system, the new recorded COVID-19 cases per day are aggregated based on positive laboratory-confirmed tests. In contrast, PS data show a significant share of reports categorized as potential COVID-19 cases that are not laboratory confirmed. Quantifying the economic value of PS system implementation remains difficult. However, scarce public funds and persisting constraints to the TS system provide motivation for a PS system, making it an important avenue for future research. The decision to set up a PS system requires careful evaluation of its expected benefits, relative to the costs of setting up platforms and incentivizing engagement to increase both coverage and consistent reporting over time. The ability to compute such economic tradeoffs might be key to have PS become a more integral part of policy toolkits moving forward. These results corroborate previous studies when it comes to the benefits of an integrated and comprehensive surveillance system, and shed light on its limitations and on the need for additional research to improve future implementations of PS platforms.
360° Diagnostic Tool to Personalize Lifestyle Advice in Primary Care for People With Type 2 Diabetes: Development and Usability Study (Preprint)
Authors: Harakeh Zeena , de Hoogh Iris M , van Keulen Hilde , Kalkman Gino , van Someren Eugene , van Empelen Pepijn , Otten Wilma
Published: March 2023

BACKGROUND

Various multifaceted factors need to be addressed to improve the health and quality of life of people with type 2 diabetes (T2D). Therefore, we developed a web-based decision support tool that comprises a more holistic diagnosis (including 4 domains: body, thinking and feeling, behavior, and environment) and personalized advice. This 360° diagnostic tool enables people with T2D and health care professionals at the general practice to obtain an overview of the most important T2D-related issues and, subsequently, determine the most suitable intervention for the person with T2D.

OBJECTIVE

This study aimed to describe the systematic and iterative development and evaluation of the web-based 360° diagnostic tool.

METHODS

We defined the requirements for the web-based 360° diagnostic tool based on previously developed tools, a literature review, and inputs from a multidisciplinary team of experts. As part of the conceptualization, we defined 3 requirements: diagnostics; feedback; and advice, consultation, and follow-up. Next, we developed and designed the content for each of these requirements. We evaluated the diagnostic part of the tool (ie, measurement instruments and visualization) with a qualitative design, in a usability study with a think-aloud strategy and interview questions, among 8 people with T2D at a Dutch general practice.

RESULTS

For each of the 4 domains, specific parameters and underlying elements were selected, and measurement instruments (including clinical data and questionnaires) were chosen. Cutoff values were defined to identify high-, middle-, and low-ranking scores, and decision rules were developed and implemented using R scripts and algorithms. A traffic light color visual design was created (profile wheel) to provide an overview of the scores per domain. We mapped the interventions that could be added to the tool and developed a protocol designed as a card deck with motivational interview steps. Furthermore, the usability study showed that people with T2D perceived the tool as easy to use, useful, easy to understand, and insightful.

CONCLUSIONS

Preliminary evaluation of the 360° diagnostic tool by experts, health care professionals, and people with T2D showed that the tool was considered relevant, clear, and practical. The iterative process provided insights into the areas of improvement, which were implemented. The strengths, shortcomings, future use, and challenges are also discussed.
Development of a Secondary Prevention Smartphone App for Students With Unhealthy Alcohol Use: Results From a Qualitative Assessment (Preprint)
Authors: Bertholet Nicolas , Schmutz Elodie , Cunningham John A , McNeely Jennifer , Gmel Gerhard , Daeppen Jean-Bernard , Grazioli Véronique S
Published: March 2023

BACKGROUND

Despite considerable efforts devoted to the development of prevention interventions aiming at reducing unhealthy alcohol use in tertiary students, their delivery remains often challenging. Interventions including information technology are promising given their potential to reach large parts of the population.

OBJECTIVE

This study aims to develop a secondary prevention smartphone app with an iterative qualitative design involving the target population.

METHODS

The app development process included testing a first prototype and a second prototype, developed based on the results of 2 consecutive qualitative assessments. Participants (aged ≥18 years, screened positive for unhealthy alcohol use) were students from 4 tertiary education institutions in the French-speaking part of Switzerland. Participants tested prototype 1 or prototype 2 or both and provided feedback in 1-to-1 semistructured interviews after 2-3 weeks of testing.

RESULTS

The mean age of the participants was 23.3 years. A total of 9 students (4/9 female) tested prototype 1 and participated in qualitative interviews. A total of 11 students (6/11 female) tested prototype 2 (6 who tested prototype 1 and 5 new) and participated in semistructured interviews. Content analysis identified 6 main themes: “General Acceptance of the App,” “Importance of the Targeted and Relevant App Content,” “Importance of Credibility,” “Importance of the App Usability,” “Importance of a Simple and Attractive Design,” “Importance of Notifications to Ensure App Use over Time.” Besides a general acceptance of the app, these themes reflected participants’ recommendations toward increased usability; to improve the design; to include useful and rewarding contents; to make the app look serious and credible; and to add notifications to ensure its use over time. A total of 11 students tested prototype 2 (6 who tested prototype 1 and 5 new) and participated in semistructured interviews. The 6 same themes emerged from the analysis. Participants from phase 1 generally found the design and content of the app improved.

CONCLUSIONS

Students recommend prevention smartphone apps to be easy to use, useful, rewarding, serious, and credible. These findings may be important to consider when developing prevention smartphone apps to increase the likelihood of app use over time.

CLINICALTRIAL

ISRCTN registry 10007691; https://www.isrctn.com/ISRCTN10007691

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s13063-020-4145-2
The epidemiological characteristics of respiratory infections and their association with air pollution and meteorological factors in China during 2004-2018: a national surveillance study (Preprint)
Authors: Liu Shelan , Jiang Hui , Tang Jia-Hong , Tang Jia-Hong , Xu Xiaolong , Yin Jinfeng , Yuan Yuan , Wang Kehan , Zhao Na , Li Weimin , Jian Hong-Lian , Chan Ta-Chien , Xu Wangli
Published: March 2023

UNSTRUCTURED

Respiratory infectious diseases are closely related to meteorological conditions and pollutants, and the changes of their epidemiological characteristics rarely explored in recent 10 years. We aimed to assess the incidence and mortality trends for respiratory infectious diseases from 2004 to 2018, and examine the associations between air pollution (PM2.5, PM10, SO2, NO2, O3 and CO exposure and meteorological conditions [mean temperature, relative humidity, air pressure, precipitation, wind speed, and sunlight hours] and respiratory infectious diseases. Data were collected from China’s notifiable infectious disease report database. Joinpoint regression models were used to examine changes in incidence and mortality for each respiratory infectious disease and to estimate average annual percentage changes (AAPCs). We used Pearson’s correlation coefficient to examine the associations between air pollution exposure and meteorological conditions. A Distributed Lag Non-Linear Model (DLNM) with relative risk was applied to analyze the impact of meteorological conditions and air pollutants on respiratory infectious diseases. We also applied a time-series decomposition approach based on LOESS (locally weighted regression) to present the seasonality of seven respiratory infectious diseases. A total of 23,444,640 cases and 45,291 deaths caused by seven respiratory infectious diseases were recorded in China, and the national mean age-standardized incidence and mortality were 115.87/100,000 and 0.23/100,000, respectively. The AAPC of age-adjusted incidence was 0.23 but was -2.11 for age-adjusted mortality; change of incidence and mortality differed by age groups. SO2 and PM10 in air pollutants and relative humidity and air pressure in climatic factors had significant effects on most respiratory diseases in this study. Based on DLNM results, meteorological factors had a stronger impact on respiratory infectious diseases with an acute and short-term lag effect compared with air pollutants.
Disinformation about diet and nutrition in social media. Scoping review (Preprint)
Authors: Segado-Fernández Sergio , Herrera-Peco Ivan , Jiménez-Gómez Beatriz , Jiménez Hidalgo Pedro Jesús , Soriano Martin Pedro José , Lozano-Estevan María del Carmen
Published: March 2023

UNSTRUCTURED

Social networks have played an essential role in the dissemination of nutrition-related information for years. Objective: to conduct a review of the international literature on the use of social media in relation to diet and nutrition disinformation. Method: A search was conducted in the following databases: Medline, Web of Science and Scopus. The time frame of this study encompassed articles published from 1st of January 2017 to 13th of December 2022. The search queries were based on the following word structures: Diet ("diet" or "nutrition" OR "nutrition facts"), Information management ("misinformation" OR "disinformation"), Social media ("Twitter" OR "TikTok" OR "Instagram" OR "YouTube" OR "Facebook"). Inclusion criteria were as follows: i) articles written in English, ii) articles published in a peer-reviewed journal, iii) articles that clearly provide the methodology and results, iv) articles in which the researchers used Twitter, TikTok, Instagram, YouTube, or Facebook to obtain the results, v) articles published from 1st of January 2017 to 1st December 2022. Exclusion criteria were defined as i) non-research articles (editorial letters, comments, pre-prints, abstracts, proceedings, book reviews, etc.), ii) articles not focused on disinformation, iii) articles focused on social networks not listed in the inclusion criteria. Results: A total of 28 articles were included in our review. The most common social media were Instagram and YouTube, with 100% of the articles presenting some form of misinformation. In many cases, the aim was to achieve relevance rather than truthfulness. More specifically, 17 of the articles analyzed advocated miracle diets as a cure for diseases, without any scientific basis. These articles included a large number of diseases such as gout, acne, or orthorexia. Conclusion: Institutions should address misinformation when it poses a threat to public health. Since this is not happening, it is important that healthcare professionals identify themselves as such in social networks and start sharing their knowledge in these new media
Pandemia, diagnóstico comunitario, activos para la salud y detección de cáncer cervicouterino en pueblos originarios. Un estudio en Sonora
Authors: Juárez Herrera y Cairo Lucero Aída , Gómez Maqueo Chew Aline , Fierro Fimbres Noelia Guadalupe , Aguayo Patrón Sandra Verónica , Jiménez Castillo Eliut Mariela
Published: March 2023

Objetivo: analizar en una comunidad del poblado Miguel Alemán, Sonora, las necesidades sociales, los activos para la salud y la detección de cáncer cervicouterino en mujeres provenientes de pueblos originarios durante la pandemia de COVID-19. Metodología: investigación con diseño mixto, encuesta para el diagnóstico situacional comunitario, estudio transversal y descriptivo, entrevista semiestructurada, observación no participante con caminata de Jane y análisis con identificación de núcleos de significados, temas, subtemas e integración de categorías. Resultados: la mayoría de las personas estaban en condiciones de marginación y pobreza con varias enfermedades crónicas e infecciosas, pero sin COVID-19. Estas no acudían a los servicios médicos por miedo al contagio y, por lo tanto, en el caso de las mujeres, no existía la posibilidad de detectar el cáncer cervicouterino. Recurrían principalmente a la medicina tradicional. Conclusiones: es importante identificar en el contexto en cuestión los activos para la salud y no generalizar los resultados. Además, hay que reconocer la diversidad social y cultural, así como concretar opciones asequibles para la detección del cáncer cervicouterino.
Mortispolítica y Neoliberalismo
Authors: Frausto Gatica Obed
Published: March 2023

Se ha generado una vinculación entre la biopolítica y el neoliberalismo. En este artículo se argumenta que la biopolítica de Foucault no fue pensada desde el neoliberalismo de la escuela de Chicago, sino desde la escuela ordoliberal. Se tiene que definir de una forma distinta el neoliberalismo, ni siquiera desde el marco de la necropolítica que parte del estado de excepción. Por el contrario, se propone la categoría de mortispolítica que expresa una mayor estatalidad y menos gubernamentalidad. La estatalidad no opera a través del estado de excepción, sino con el estado de la ley. Pero no es una ley igual para todos o indistinta, más bien es distintiva para quienes tienen privilegio material, racial y social. La mortispolítica se expresa como una necrosociedad que ha distorsionado los equilibrios de las pulsiones de la vida y la muerte que se puede observar en la figura del acróbata nietzscheano, prin- cipalmente porque la forma de vida al placer y al goce extremo desvaloriza la muerte, y al desvalorizarla expande la muerte entre la población humana y el planeta. En eUa se observa una lógica de la mortispolítica legal-privilegio y en los países de América Latina se da una estatalidad mortispolítica.
Disputa por la soberanía. Crimen Organizado y defensa comunitaria como gobiernos privados indirectos en México
Authors: Hernández Morales Alan Salvador
Published: March 2023

El presente artículo pretende analizar la disputa por el poder soberano durante las últimas décadas en México, con la finalidad de contribuir al entendimiento de la actualidad nacional caracterizada por la contienda armada entre distintos actores políticos y sociales. Particularmente, se realiza un estudio contextual de este tipo de conflictos en los estados de Guerrero, Michoacán y Chiapas, en los cuales ha habido una importante presencia de las Fuerza Armadas, el control territorial del crimen organizado y el surgimiento de diversas expresiones de defensa comunitaria. Para ello, se retoman principalmente los conceptos de soberanía y gobierno privado indirecto de Achille Mbembe, ya que son herramientas teóricas de gran utilidad para estudiar la situación de los Estados periféricos inmersos en la lógica de la globalización. A partir de la información analizada, se concluye que la disputa por el poder soberano a través del surgimiento de gobiernos privados en México es un fenómeno con predisposición a volverse más recurrente, puesto que se produce como consecuencia de un escenario de dilución de la estatalidad como reguladora de las relaciones sociales, proceso que inició desde finales del siglo xx y continúa hasta la fecha.
Los alimentos y el empleo de veneno en situaciones de conflicto armado: análisis a la luz de los medios y métodos de guerra prohibidos en el derecho internacional humanitario
Authors: Fillol Mazo Adriana
Published: March 2023

El presente artículo tiene como objetivo analizar las obligaciones jurídico-internacionales, así como su naturaleza, para las partes del conflicto armado, internacional y no internacional, en relación con la prohibición del envenenamiento de los alimentos como método y medio de guerra. Dado que los conflictos armados conducen a las formas más severas de hambruna de la población civil y que no se ha localizado a lo largo del derecho de los conflictos armados, una prohibición explícita de envenenar los alimentos como método de guerra, es por lo que nos hemos planteado escoger este tema de investigación. El trabajo se complementa con el análisis de la prohibición de envenenar los alimentos como medio de guerra y de la posible atribución de responsabilidad penal internacional por violación de la obligación que proscribe esta práctica, que aun no siendo explícita o específica se deduce de las normas convencionales, consuetudinarias y de los principios del derecho internacional humanitario.
Implicaciones jurídicas de la interrelación entre competencia económica y comercio internacional en Norteamérica
Authors: Leal Buenfil Rubén
Published: March 2023

Realizamos un análisis comparativo de las regulaciones de competencia económica y comercio internacional entre México, Estados Unidos y Canadá. Observamos una correlación cuantitativa positiva entre el volumen de comercio regional y la entrada en vigor de legislación de competencia y comercio en Norteamérica. Adicionalmente, utilizamos el método deductivo para identificar las implicaciones jurídicas de la interrelación de las materias en estudio. Concluimos que la regulación comercial debería adoptar un enfoque transversal decompetencia para maximizar el bienestar social tanto nacional como regional, en el marco del T-MEC. Además, se sugiere homologar criterios administrativos y judiciales en materia decompetencia para hacer de Norteamérica una región económica más predecible en términos legales, reformando legislaciones potenciales distorsionadoras de eficiencias productivas, como la Webb-Pomerene Act de Estados Unidos.
Analizar la exclusión social para calibrar el desarrollo. Apuntes para el derecho social
Authors: Tello Ibarra Jordan Vladimir
Published: March 2023

Una de las premisas del derecho social es construir andamiajes para el acceso y ejercicio de derechos fundamentales para mejorar la vida: salud, empleo, educación, vivienda, seguridad social, etcétera. Esos derechos han sido imbricados con el concepto de “desarrollo”, el cual ha formado parte de los discursos y paradigmas económicos de las últimas décadas y como eje de las políticas públicas en materia de combate a la pobreza. El presente artículo es una reflexión conceptual de exclusión social, como una posibilidad teórica que permite repensar los alcances del desarrollo. Así, se concluye que el derecho social es paralelo al desarrollo, pero requiere instalarse en el combate a los ámbitos y factores de exclusión social, que limitan el ejercicio de derechos fundamentales y el reconocimiento de la justicia social.
Introdução à discussão sobre gênero na Geografia
Authors: SANTOS JUNIOR WASHINGTON RAMOS DOS
Published: March 2023

O objetivo deste ensaio é introduzir a discussão de Gênero nas disciplinas História do Pensamento Geográfico e Introdução à Ciência Geográfica, para as turmas ingressantes de bacharelado e de licenciatura em Geografia. Nesse sentido, cabe ressaltar que as deficiências da educação básica contribuem para o desconhecimento de uma série de conceitos fundamentais para as disciplinas introdutórias do pensamento geográfico, e isso não é diferente com o conceito de Gênero. Nossa abordagem, portanto, inicia-se com o fato biológico e, em seguida, aborda as questões culturais relacionadas ao tema, mencionando sua geo-grafia. A metodologia empregada consiste em revisão bibliográfica da temática, desde a Biologia até a Geografia, com enfoque na invenção e nas políticas do sexo.
Effect of gut flora mediated-bile acid metabolism on intestinal immune microenvironment
Authors: Zhang Yan , Gao Xueyan , Feng Yudi , Liu Yang , Gao Shuochen , Pei Liping , Wang Wenkang , Sun Zhenqiang , Liu Lin , Wang Chengzeng
Published: March 2023

According to reports, gut microbiota and metabolites regulate intestinal
immune microenvironment. In recent years, an increasing number of
studies reported that bile acids (BAs) of intestinal flora origin
affects T helper cells and Treg cells. Th17 cells play a
pro-inflammatory role and Treg cells usually act an immunosuppressive
role. In this review, we emphatically summarized the influence and
corresponding mechanism of different configurations of the LCA and DCA
on intestinal Th17 cells, Treg cells and intestinal immune
microenvironment. The regulation of BAs receptors G protein-coupled bile
acid receptor 1 (GPBAR1/TGR5) and farnesoid X receptor (FXR) on immune
cells and intestinal environment are elaborated. Furthermore, the
potential clinical applications above were also concluded in three
aspects. These above will help researchers better understand the effects
of gut flora on the intestinal immune microenvironment via BAs and
contribute to the development of new targeted drugs.
Exploring automated object detection methods for manholes using classical computer vision and deep learning
Authors: Rao Shika , Mitnala Nitya
Published: March 2023

Open, broken, and improperly closed manholes can pose problems for autonomous vehicles and thus need to be included in obstacle avoidance and lane-changing algorithms. In this work, we propose and compare multiple approaches for manhole localization and classification like classical computer vision, convolutional neural networks like YOLOv3 and YOLOv3-Tiny, and vision transformers like YOLOS and ViT. These are analyzed for speed, computational complexity, and accuracy in order to determine the model that can be used with autonomous vehicles. In addition, we propose a size detection pipeline using classical computer vision to determine the size of the hole in an improperly closed manhole with respect to the manhole itself. The evaluation of the data showed that convolutional neural networks are currently better for this task, but vision transformers seem promising.
Existence result for stochastic fractional coupled system
Authors: Bouteraa Noureddine
Published: March 2023

This paper focuses on the study of the existence of a mild solution to time
and space-fractional stochastic equation perturbed by multiplicative white
noise. The required results are obtained by stochastic analysis techniques,
fractional calculus, semigroup theory and Leray-Schauder nonlinear
alternative.
On the Karush-Kuhn-Tucker reformulation of the bilevel optimization problems on Riemannian manifolds
Authors: Liao Jiagen , Wan Zhongping
Published: March 2023

Bilevel programming problems are often reformulated using the
Karush-Kuhn-Tucker conditions for the lower level problem resulting in a
mathematical program with complementarity constraints (MPCC). First, we
present KKT reformulation of the bilevel optimization problems on Riemannian
manifolds. Moreover, we show that global optimal solutions of
theMPCCcorrespond to global optimal solutions of the bilevel problem on the
Riemannian manifolds provided the lower level convex problem satisfies the
Slater?s constraint qualification. But the relationship between the local
solutions of the bilevel problem and its corresponding MPCC is incomplete
equivalent. We then also show by examples that these correspondences can
fail if the Slater?s constraint qualification fails to hold at lower-level
convex problem. In addition,M- and C-type optimality conditions for the
bilevel problem on Riemannian manifolds are given.
Hermite-Hadamard type inequalities for harmonically-convex functions using fuzzy integrals
Authors: Latif Muhammad , Du Tingsong
Published: March 2023

In this study, Hermite-Hadamard type inequalities for harmonically-convex
functions using fuzzy integrals are presented. Some examples are also given
to illustrate the obtained results.
Properties of dual Toeplitz operator on the orthogonal complement of the pluriharmonic Bergman space of the unit ball
Authors: Hu Yinyin , Lu Yufeng , Yang Yixin
Published: March 2023

In this paper, we characterize the hyponormal dual Toeplitz operators with
special symbols on the orthogonal complement of the pluriharmonic Bergman
space of the unit ball. Also we completely characterize the pluriharmonic
symbols for (semi)commuting dual Toeplitz operators.
Hermeneutic Epistemology (Comparative Study of Deconstruction of Derrida and Manhaj Tafsir Muhammadiyah)
Authors: Hamdani Fitrah
Published: March 2023

The development of qur'anic interpretation has had its ups and downs, especially during the inclusion of the role of reason in the tradition of classical interpretation. Initially, reason was used as an aid in the process of berijtihad, in order to find common ground between the text and the context so that the resulting meaning would correspond to what was needed. The use of reason will always have to do with the adoption of science. Through this process, approaches that are considered foreign (outside of Islam) are included as a logical consequence that Muslims must face. Such as the inclusion of hermeneutics as an approach in understanding the text of the Qur'an.Based on these conditions, this paper tries to compare the hermeneutics of Derrida's deconstruction with the interpretive manhaj in Muhammadiyah through the frame of productive reading. This paper does not discuss hermeneutics as a concept of interpretation in general, but hermeneutics is seen through Derrida's theory of deconstruction.This paper the author will use a comparative method by trying to compare Derrida's deconstruction theory at the stage of thinking in deconstruction with the manhaj system in Muhammadiyah with the aim of getting a clear picture of the epistemological basis of each approach in interpreting the text.  Keywords: Hermeneutics, Deconstruction and Manhaj Tarjih
Impact Digital Business Strategy on Competitive Advantage in the Banking Sector
Authors: Priyanto Panji , Murwaningsari Etty , Augustine Yvonne
Published: March 2023

This study investigates the connection between digital business strategy and achieving competitive advantage by using four capabilities, namely managerial, operational, IT, and e-collaboration capabilities, that depict a digital business strategy seen as a need to achieve a digital business strategy to improve and boost competitiveness. Structural Equation Modeling (SEM) was used as one of the data analysis techniques, and as many as 832 banking personnel participated in the survey as respondents. The results show that a company's competitive advantage is strongly influenced by its digital business strategy, represented by organizational and managerial skills, operational capabilities, IT skills, and electronic collaboration capabilities. In addition, this study sheds fresh light on the importance of sustainability strategy in the relationship between digital business strategy and competitive advantage Furthermore, the study's conclusions can be applied to other growing markets.
Light In The Dark Azyumardi Azra's Cotribution In Framing Novelty of Nusantara Islam
Authors:   Universitas Sanata Dharma Yogyakarta, Martinus Joko Lelono
Published: March 2023

Azyumardi Azra significantly contributed to re-framing the Indonesian situation during his lifetime as a scholar. This article works on the literature review of the works of Azra. It aims to perform an analytical article that helps people comprehend that social reality lives in certain identity politics. Azra proposed to look at reality from the "Optimistic Perspective” that has become a distinguished perspective in looking at the present situation of Indonesian Islam. Using the social framing theory by Erving Goffman, this article contributes to performing the social life from a new perspective. In the Catholic perspective of interreligious dialogue, the work of Azyumardi Azra is in line with the contemporary efforts of Pope Francis. As an institution, a religion derives into a certain situation that emerges the complexity of its adherents’ way of thinking, however, certain influential figures build new social frameworks that enable people to have a distinctive way from the directed situation.