bluuebunny/crossref_metadata_2025 huggingface dataset:
Are ecological momentary assessment measures of intervention change worth the trouble? Evaluation in four digital mental health trials (Preprint)
Authors: Webb Christian , Hilt Lori , Swords Caroline , Bolt Daniel , Fisher Hadar , Goldberg Simon
Published: November 2024

UNSTRUCTURED

Ecological momentary assessment (EMA) is increasingly being incorporated into intervention studies to acquire a more fine-grained and ecologically valid assessment of change. The added utility of including relatively burdensome EMA measures in a clinical trial hinges on several psychometric assumptions, including that these measure are: (1) reliable, (2) related but not redundant with conventional self-report measures (convergent and discriminant validity), (3) sensitive to intervention-related change, and (4) associated with a clinically-relevant criterion of improvement (criterion validity) above conventional self-report measures (incremental validity). Using data from 4 app-based meditation trials (N = 412), we examined the reliability, validity, and sensitivity to change of conventional self-report and EMA measures of improvement in rumination. Conventional self-report and EMA measures of rumination were only modestly correlated, particularly with regards to change over time, which may be due to their lower reliability. Changes in rumination were larger for conventional self-report than EMA. Notably, change in both self-report and EMA rumination each accounted for unique variance in depressive symptom improvement, demonstrating incremental predictive validity. Conventional self-report and EMA measures of rumination provide distinct and clinically meaningful information. Researchers using EMA should consider the psychometric properties of their measures and the precise construct they intend to capture.
Detection and analysis of circadian biomarkers for metabolic syndrome using wearable data and explainable artificial intelligence (Preprint)
Authors: Kim Jeong-Kyun , Mun Sujeong , Lee Siwoo
Published: November 2024

BACKGROUND

Digital biomarker detection using wearable devices is utilized as a solution for managing metabolic syndrome (MetS) in daily life.

OBJECTIVE

This study aimed to detect digital biomarkers based on sleep and circadian rhythm using step counts and heart rate data obtained from wearable devices and to analyze important biomarkers for MetS risk groups.

METHODS

Circadian rhythm markers based on heart rate and step counts were analyzed, including the newly proposed continuous wavelet circadian rhythm energy. The detected markers were analyzed for their contribution to MetS using SHapley Additive exPlanations, Explainable Boosting Machine, and Tabular Neural Network models.

RESULTS

Analysis of sleep and circadian rhythm biomarkers using statistical analysis and artificial intelligence methods revealed that circadian rhythm markers were more important for MetS than sleep markers. Among circadian rhythm markers, heart rate-based markers were found to be more important than step counts. The continuous wavelet circadian energy proposed in this study showed the highest contribution to MetS in the artificial intelligence analysis results.

CONCLUSIONS

The risk of MetS can be continuously identified and monitored in daily life by utilizing circadian rhythm markers.
An In vitro Investigation of the Potential Synergistic Effect of 3-Hydrazinoquinoxaline-2-Thiol and Thymoquinone’s against Methicillin Resistant Staphylococcus aureus (MRSA)
Authors: Ibrahem Karem , Alhazmi Wafaa , Niyazi Hanouf A. , Niyazi Hatoon A. , Saleh Bandar , Ekhmimi Tariq , Mokhtar Jawahir A. , Attallah Dalya , Bazuhair Mohammed , Alkuwaity Khalil , Sait Ahmad , Mufrrih Mohammed , Ismail Mazen , Almoghrabi Yousef , Daghistani Hussam , Alharbi Ohood , Altayb Hisham , Alfadil Abdelbagi
Published: November 2024

Bacterial infections continue to pose a significant global health threat, further intensified by the increasing prevalence of antibiotic resistance. Methicillin-resistant Staphylococcus aureus (MRSA) poses significant threats, especially in healthcare settings around the world. Conventional treatments face some limitations due to development of antimicrobial resistance, emphasizing the urgent need to explore alternative treatment strategies. In this study, we propose the potential synergistic activity of thymoquinone and 3-hydrazinoquinoxaline-2-thiol (3HT) to combat MRSA infections. The minimum inhibitory concentrations (MICs) of both thymoquinone and 3HT were assessed across twenty-two clinical MRSA strains. Thymoquinone demonstrated the minimum inhibitory concentration (MIC) values range between 8 and 128 µg/ml., while 3HT exhibited MIC levels varying from 16 to 32 µg/ml. Moreover, the checkerboard-assay was utilized to evaluate the integration of the following antimicrobial agents; thymoquinone and 3HT. Thymoquinone and 3HT bind to PBP2a leading to reduction in MRSA antimicrobial resistance via significantly disrupting its structure and function. Our study reveals an in-vitro synergistic interaction between these compounds with a fractional inhibitory concentration index (FICI) less than 0.5 against different isolated MRSA strains. While further research is necessary, our findings offer a promising approach for developing new effective MRSA treatments.
Effect of Bluetongue Virus Serotype 1 Infection During Late-stage of Gestation in IFNAR1-blocked Immunocompetent Mouse Model
Authors: Saminathan M. , Vineetha S. , Biswas S.K. , Milton A.A.P. , Pavulraj S. , Dhama K. , Singh K.P.
Published: November 2024

Bluetongue (BT) is an economically significant viral disease caused by bluetongue virus (BTV). BTV is spread by arthropods, which affects domestic and wild animals. In fetal ruminants, BTV exhibits neurotropism, leading to abortion and congenital defects in brain especially in cattle and sheep when infected in utero. Transplacental transmission (TPT) of wild Indian BTV-1 in late pregnancy has never been proven experimentally. This study is the first to demonstrate TPT of wild Indian BTV-1 during late pregnancy using an immunocompetent mouse model of IFNAR1 blockade. The present study examines sequential pathology, developmental anomalies, demonstration of BTV-1 antigen localization in the reproductive organs, haematological and biochemical alterations, and humoral immunity during the late stage of gestation. During late stage of gestation, the rate of TPT was notably higher at 80.00%. Clinical signs became increasingly noticeable in dams from 5 dpi onward, including symptoms such as abortion, anorexia, ocular discharge, and huddling tendency. Reduced growth rate, rough hair coat, and head tilting due to nervous signs were observed in 10-day-old fetuses. BTV-1 infection during the late stage of gestation caused abortion, maceration, necro-haemorrhagic lesions in reproductive organs, hemorrhages in foetal organs, and non-significantly decreased bone size (Alizarin red staining) in fetuses. Perivascular hemorrhages due to endothelial damage in lungs, interstitial pneumonia and meningitis were observed in 10-day-old fetuses. BTV-infected pregnant mice showed leukopenia with lymphopenia and seroconversion by 6 dpi (21 days of gestation). Further, significant alterations in serum biochemical values were observed when compared them to those of the uninfected control group. BTV-1 antigen was demonstrated in foetuses, placenta, uterus, and ovaries using immunohistochemistry and RT-PCR. This mouse model presents a suitable platform for studying the mechanisms underlying transplacental transmission.
The link between public investment strategy and public debt: An empirical assessment
Authors: Cerpja Teuta , Kola Forcim
Published: November 2024

Economic growth and long-term output are significantly impacted by public investments. Public debt serves as a major source of funding for these investments. The purpose of this study is to assess, along with a few other macroeconomic factors, the short- and long-term effects of Albania’s external and domestic debt on public investment. The empirical research was conducted using the autoregressive distributed lag (ARDL) estimation approach, based on annual data for the years 2000–2022. Among other things, the results demonstrated that Albania’s public investments are significantly and negatively impacted in the long-run term by external debt. However, for the period under consideration, there is no statistically significant correlation between internal debt and public investments. Furthermore, we discovered that the amount of public investments is positively and significantly correlated with both the gross domestic product (GDP) and foreign direct investments (FDI). The conclusions of the research can be helpful to the Albanian government because they shed light on the relationship between two main categories of public debt and public investments. The paper suggests that stringent project implementation guidelines be put in place by the government to guarantee profitable borrowing and closely monitor public debt.
The laboratory investigation of the capillarity of various dental solutions at three temperature levels
Authors: Ilic Veljko , Cetkovic Dejan , Postic Srdjan , Brkovic Snezana , Ilic Dragan
Published: November 2024

Introduction/Objective. Many oblong micro-spaces of less than 500 ?m exist within oral cavity, such as dentine canalicular spaces, gaps, recesses, gingival sulcus etc. Since these spaces are susceptible to food and pathogenic microbe?s accumulation, most dental solutions should be able to penetrate into those micro-spaces exhibiting therapeutic effects. The aim of this study was to evaluate and compare the effect of capillarity of commonly used dental solutions at three temperature levels. Methods. The following solutions were examined: ethanol (EA), sodium hypochlorite (SH), hydrogen peroxide (HP), chlorhexidine, saline, citric acid, ethylenediaminetetraacetic acid (EDTA), and distilled water. The samples were exposed to the temperature of 20?C, 38?C, and 50?C measuring capillary by glass tube of 400 ? diameter. The capillary effects of the solutions were recorded on the graduated capillary tube (mm) and data were statistically processed. Results. Seventy-percent EA showed the highest raise of capillarity (20?50?C; 8.8 ? 1.1) and 2.5% SH (2.1 ? 1.5) and 3% HP (2.1 ? 1.6) showed the lowest. The highest capillarity at 50?C was showed by 17% EDTA (40.1 ? 1.4) while 4% SH showed the lowest capillarity (25.9 ? 2.1) (p < 0.05). Conclusion. The level of capillarity of dental irrigating solutions was enhanced with temperature increase in all solutions, but not to the same extent.
Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors
Authors: Waterman Hannah L. , Moore Mary Courtney , Smith Marta S. , Farmer Ben , Yankey Kalisha , Scott Melanie , Edgerton Dale S. , Cherrington Alan D.
Published: November 2024

Glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second-meal phenomenon). We previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (HGU). Although the route of insulin delivery is an important determinant of the mechanisms by which insulin regulates liver glucose metabolism (direct hepatic vs. indirect insulin action), it is not known whether insulin’s delivery route affects the second-meal response. To determine whether morning peripheral insulin delivery (as occurs clinically, i.e., subcutaneously) can enhance afternoon HGU, conscious dogs were treated in the morning with insulin delivered either via the portal vein or peripherally (leg vein), while glucose was infused to maintain euglycemia. Consequently, arterial insulin levels increased similarly in both groups, but relative hepatic insulin deficiency occurred with peripheral insulin delivery. In the afternoon, all animals were challenged with the same hyperinsulinemic-hyperglycemic clamp to simulate identical postprandial-like conditions. The substantial enhancement of HGU in the afternoon caused by morning portal vein insulin delivery was lost when insulin was delivered peripherally. This indicates that morning insulin does not cause the second-meal phenomenon via its indirect actions on the liver but, rather, through direct activation of hepatic insulin signaling.

Article Highlights

Morning insulin delivery primes the liver for increased hepatic glucose uptake (HGU) later in the day, but until now, the mechanism (direct hepatic and/or indirect insulin action) remained unclear. This study compared insulin infusion via endogenous (hepatic portal vein) and clinical (peripheral) routes to assess their impact on afternoon hepatic glucose disposal. Arterial hyperinsulinemia in the morning, without a concomitant increase in insulin at the liver, failed to induce a significant enhancing effect on afternoon HGU and glycogen storage, unlike morning hepatic portal vein insulin delivery, which did. These findings highlight the importance of achieving appropriate hepatic insulin exposure in the morning to effectively prime the liver for enhanced glucose disposal later in the day.
A Systematic Review and Meta-analysis on the Safety and Efficacy of Sodium–Glucose Cotransporter 2 Inhibitor Use in Hospitalized Patients
Authors: Gao Frank M. , Ali Aleena S. , Bellomo Rinaldo , Gaca Michele , Lecamwasam Ashani , Churilov Leonid , Ekinci Elif I.
Published: November 2024

BACKGROUND

The safety and efficacy of sodium–glucose cotransporter 2 (SGLT2) inhibitors in hospitalized patients are unclear.

PURPOSE

To evaluate outcomes of inpatient SGLT2 inhibitor use.

DATA SOURCES

MEDLINE, Embase, Emcare, and Cochrane databases were searched through 29 May 2024.

STUDY SELECTION

Randomized controlled trials (RCTs) and observational cohort studies with assessment of SGLT2 inhibitor use in patients hospitalized for any reason were included.

DATA EXTRACTION

Study characteristics and clinical outcomes were extracted.

DATA SYNTHESIS

We performed a random-effects meta-analysis analyzing RCTs and cohort studies separately. Heterogeneity was quantified with the I2 statistic. Twenty-three RCTs comprising 19,846 participants (29.5% with type 2 diabetes) with comparison of SGLT2 inhibitors with placebo or active comparator were included. Ketoacidosis rates were 0.210 per 100 person-years (95% CI 0.119, 0.370) for SGLT2 inhibitors and 0.140 per 100 person-years (95% CI 0.070, 0.280) for control (rate ratio 1.50 [95 CI 0.56, 4.23], P = 0.38). SGLT2 inhibitor use was associated with fewer readmissions and urgent visits (odds ratio [OR] 0.64 [95 CI 0.47, 0.86], P < 0.01) and lower mortality rates (OR 0.74 [95% CI 0.56, 0.98], P = 0.03) in heart failure trials and lower incidence of acute kidney injury (OR 0.76 [95% CI 0.60, 0.97], P = 0.03) among all RCTs. Twenty observational studies were included and did not show increased adverse events.

LIMITATIONS

Ketoacidosis rates were low, likely leading to lack of power to detect significant differences.

CONCLUSIONS

SGLT2 inhibitor use among hospitalized patients was associated with numerically higher rates of ketoacidosis, although further studies are required.
Effects of Integrated Care Approaches to Address Co-occurring Depression and Diabetes: A Systematic Review and Meta-analysis
Authors: Cooper Zach W. , O’Shields Jay , Ali Mohammed K. , Chwastiak Lydia , Johnson Leslie C.M.
Published: November 2024

BACKGROUND

Depressive symptoms frequently co-occur with diabetes and, when unaddressed, can function to worsen diabetes control and increase the risk of diabetes-related morbidity. Integrated care (IC) approaches aim to improve outcomes among people with diabetes and depression, but there are no current meta-analyses examining their effects.

PURPOSE

In our study we summarize the effects of IC approaches to address depression and diabetes and examine moderating effects of IC approaches (e.g., behavioral intervention used; type of IC approach).

DATA SOURCES

A systematic search was conducted of PubMed, PsycInfo, CINAHL, and ProQuest.

STUDY SELECTION

Two reviewers triaged abstracts and full-text articles to identify relevant articles. Randomized controlled trials with enrollment of participants with diabetes and depressive symptoms and with provision of sufficient data on depression scores and hemoglobin A1c were included.

DATA EXTRACTION

Two reviewers extracted demographic information, depression scores, diabetes outcomes, intervention details, and the risk of bias for each study.

DATA SYNTHESIS

From 517 abstracts, 75 full-text reports were reviewed and 31 studies with 8,843 participants were analyzed. Among 26 studies with reporting of HbA1c, IC approaches were associated with a significant between-group difference regarding the percent decrease of HbA1c (d = −0.36, 95% CI −0.52 to −0.21). Studies that included a combination of behavioral interventions (behavioral activation with cognitive behavioral therapy) showed greater reductions in HbA1c. Among 23 studies with reporting of depressive symptoms, the pooled effect of IC approaches lowered depressive scores by 0.72 points (95% CI −1.15 to −0.28).

LIMITATIONS

The inclusion of a wide range of IC approaches increased study heterogeneity. A random effects model and sensitivity analyses mitigated this limitation.

CONCLUSIONS

IC approaches are associated with improved glycemia and depressive symptoms in comparison with treatment as usual.
Surface Roughness and Color Stability of Newly Developed Resin Composites With Color Adjustment Potential After Immersion in Staining Solutions
Authors: Maghaireh GA , Alzraikat H , Alakhras HK
Published: November 2024

The aim of this this study was to evaluate the surface roughness and color stability of resin composites (RCs) with color adjustment potential (CAP): Omnichroma (OM), (Tokuyama Dental, Tokyo, Japan); Neo Spectra ST (NS) (Dentsply Sirona, York, PA,USA); and Charisma Diamond One (CD) (Kulzer, Hanau, Germany), compared to a conventional RC, Filtek Z350XT (FZ) (3M ESPE, St. Paul, MN,USA), after immersion in three staining solutions, cola, coffee, and black tea, with distilled water as a control. Forty specimens (8 mm diameter x 2 mm thickness) were prepared for each RC material and divided into subgroups (n=10/group) based on the immersion solution. Surface roughness was measured at baseline and after 21 days of immersion using a non-contact optical profilometer. Color change (ΔE00) was evaluated at baseline, 1, 7, and 21 days with a spectrophotometer.

The results showed that FZ demonstrated the lowest surface roughness (0.14), significantly differing from that of the other RCs with CAP (p<0.05), while no significant differences in surface roughness were observed between RCs with CAP (p>0.05). There were no significant changes in surface roughness before and after immersion in various solutions. The results for color change (ΔE00) were statistically significant. Neo Spectra ST showed the lowest tendency for color change, while Filtek Z350XT displayed a moderate potential, and Omnichroma and Charisma Diamond One showed the highest potential for color change.
Effects of Fluoride-containing Biomimetic Agents on Remineralization and Color Change of Enamel White Spot Lesions: An In Vitro Study
Authors: Fırıncıoğullar EC , Urdinç AM
Published: November 2024

Introduction:

The aim of this study was to evaluate the effects of fluoride-containing remineralization agents on enamel white spot lesions.

Methods and Materials:

Twenty bovine incisors were cut mesio-distally and occluso-gingivally, creating 80 specimens, and divided into four groups (n=20/group): 1) control (no treatment); 2) fluoride varnish (Voco Profluoroid 5% NaF Varnish, VOCO Dental, Cuxhaven, Germany); 3) CPP-ACFP (MI Paste Plus with Recaldent, GC Corporation, Tokyo, Japan),; 4) self-assembling peptide (P11-4F, CURODONT Repair Fluoride Plus, Credentis AG, Windisch, Switzerland). After a three-week demineralization-remineralization cycle, white spot lesions were observed on the specimens. Before applying the remineralization agents, baseline demineralization values were determined using DIAGNOdent 2095, QLF-D Biluminator, SEM-EDS (KaVo Dental, Charlotte, NC, USA), and color values were measured by Vita EasyShade (Vita Zahnfabrik, Bad Säckingen, Germany). Remineralization agents were applied once, following the manufacturers’ instructions. The remineralization capacities of these agents and their effects on color change were evaluated at four time points: baseline (T0), demineralization (T1), and remineralization on the seventh (T2) and 30th (T3) days.

Results:

After 30 days, CPP-ACFP and P11-4F showed significantly greater Ca (% by weight), F (% by weight), and Ca/P ratio than the fluoride varnish group (p<0.05). SEM images revealed that in the groups where the remineralization agent was applied, the pores and tubules were blocked, and the surfaces were covered, whereas these findings were not observed in the control group. Based on QLF-D Biluminator data, P11-4F application provided more successful fluorescence changes compared to CPP-ACFP and fluoride applications and was statistically more effective in reducing lesion volume and maximum fluorescence loss (p<0.05). Significant differences were observed among the four groups at the seventh (T2) and 30th days (T3) in the laser fluorescence evaluation with DIAGNOdent (p<0.05). On the seventh day, the fluoride group exhibited greater effectiveness than the control group, while on the 30th day, the CPPACFP group demonstrated superior improvement over the control group (p<0.05). According to color change results, applying a remineralization agent was found to be a statistically successful method in restoring the tooth’s original color (p<0.05). However, there were no significant differences among the treatment groups (p>0.05).

Conclusions:

CPP-ACFP and P11-4F demonstrated positive effects on remineralization at the seventh and 30th days. Applying a remineralization agent is a viable option for blocking pores and tubules on demineralized enamel. The color change related to the use of the remineralization agent showed a positive effect over time.
Physical and Mechanical Properties of Bulk-fill Resin Composites Submitted to Additional Polymerization for Use in Semi-direct Restorations
Authors: Botrel BJ , Condi ML , Turssi CP , Gomes-França FM , Vieira-Junior WF , Basting RT
Published: November 2024

Physical and mechanical properties of high-viscosity bulk-fill resin composites submitted to additional polymerization for semi-direct use were evaluated. Filtek Z350 XT, Aura Bulk Fill, Beautifil Bulk Restorative, Filtek One Bulk Fill Restorative, and Tetric N-Ceram Bulk Fill were submitted to additional polymerization to evaluate sorption, solubility, surface microhardness, surface roughness before and after simulated brushing, color stability after coffee staining, flexural strength, elastic modulus, and modulus of resilience. Filtek Z350 XT and Filtek One Bulk Fill Restorative showed higher sorption values, while Aura Bulk Fill showed higher solubility (p<0.0001). Microhardness values were significantly higher for Filtek Z350 XT (p<0.0001). Roughness increased after wear for all resins (p<0.05). All resins exhibited staining, with significantly higher ΔEab, ΔE00, and ΔWID values observed for Beautifil Bulk Restorative (p<0.0001). Flexural strength values were higher for Filtek Z350 XT and Filtek One Bulk Fill Restorative in comparison with the others (p<0.0001). Filtek One Bulk-Fill had higher elastic modulus and modulus of resilience values (p<0.0001). Physical and mechanical properties varied according to the composition. None of the bulk-fill resins showed surface microhardness and roughness properties after brushing similar to or superior to those of the conventional type. Color stability after staining depended on resin composition, with Beautifil Bulk Restorative showing more intense staining.
Dimensiones temporales en narrativas militantes nacional-populares en Argentina: un abordaje generacional
Authors: Montali Guido
Published: November 2024

Este artículo aborda la militancia juvenil oficialista surgida en Argentina durante los años de gobierno del Frente para la Victoria (2003-2015). Aunque este fenómeno ha sido objeto de estudios previos, el presente trabajo se centra en un aspecto poco explorado: las dimensiones temporales en la construcción de sus narrativas. A partir de entrevistas realizadas a militantes de organizaciones, se analiza la articulación temporal de acontecimientos que configuran su inscripción en la tradición nacional-popular. La exposición se organiza en tres partes: primero, se precisa el escenario y el objeto del trabajo; segundo, se analizan las relaciones entre las nociones de generaciones, tradiciones, narrativas y temporalidad; finalmente, se ofrece una interpretación sobre cómo las temporalidades en las narrativas contribuyen a la configuración de identificaciones generacionales.
Comprehensive Financial Planning for a Sustainable Retirement†
Authors: Tahani Nabil , Robinson Chris
Published: November 2024

We demonstrate a comprehensive approach to the dual problems of saving enough for retirement and determining how much saving is enough at retirement date, using a probabilistic (stochastic) model. Our model estimates the probability of success of a comprehensive plan that spans the life cycle. Retirement plans are riskier than the financial planners’ deterministic models show, using a simple case study as a comparative example. Variables the family can control for a successful retirement plan are the patterns of pre-retirement saving and retirement consumption, the probability of running out of money in retirement that the family will accept, and the age of retirement.
Performance studies of premixed blended hydraulic cement to revolutionize concrete production
Authors: Lin Kae-Long , Lin Wei-Ting , Fiala Lukáš , Kočí Jan , Lee Po-En , Hsu Hui-Mi
Published: November 2024

In recent years, ready-mix concrete plants have increasingly utilized premixed blended hydraulic cement. These formulations incorporate a higher mineral admixture content than traditional ternary concrete mixtures, resulting in improved durability, compactness, and reduced hydration heat during curing. This study examined four concrete proportions with a water–binder ratio of 0.32, focusing on workability, compression strength, and chloride penetration resistance. The research also considered economic effects and carbon emissions. The findings revealed that premixed blended hydraulic cement improved late strength development and reduced chloride permeability. Additionally, the partial replacement of cement with silica fume enhanced early strength and chloride resistance. However, these benefits came with trade-offs, including adverse effects on workability and increased hydration heat. Notably, a 50% cement mixture in premixed blended hydraulic cement emitted 42–49% less CO2 than conventional formulations, highlighting its potential for reducing environmental impact in concrete production.
Yield of Bunches of Fresh Oil Palm Fruits (Elaeis Guineenses JACQ.) Grown in Pará: Barrier to Illegal Transport
Authors: Santana Antônio Cordeiro de , Lins Paulo Manoel Pontes , Dantas Rúbia Carla Ribeiro , Santana Ádina Lima de , Costa Filho Geraldo de Araújo
Published: November 2024

Objective: The goal of this study was to generate technical and scientific information to support the inspection of transportation of fresh fruit bunches (FFB) of oil palm in the state of Pará and to estimate the average yield curve (AYC) of FFB of varieties of oil palm cultivated in the municipalities of Pará.
 
Theoretical framework: Theories about limited rationality and asymmetric information was applied to production and commercialization negotiations of FFB oil palm in the state of Pará. Econometric modelling and statistical tests were used to estimate the AY curve and to compare the sample averages among the business production, family farming, and the Brazilian Institute of Geography and Statistics (IBGE).
 
Results and conclusion: The maximum AY of FFB oil palm were estimated for the state of Pará, Brazil (16.27 ± 1.46 t/ha), and to the most productive variety, Compacta-Nigeria (23.86 ± 2.24 t/ha). It was evident that AY of FFB for the Family farmers (average 22.63 ± 3.17 t/ha) was higher than that obtained by companies (average of 17.10 ± 4.05 t/ha) and that reported by IBGE (average of 15.98 ± 1.25 t/ha). The IBGE data are not different or superior to those of companies.
 
Research implications: The study estimated the FFB oil palm AY curve by variety cultivated in the state of Pará to enable the traceability of FFB oil palm production and transportation. It validates IBGE data as a mechanism for monitoring the transit of CFF.
 
Originality/value: The CFF yield curve adds unprecedented scientific knowledge to support the traceability of oil palm production. The data provided by this research contributes to reduce the information asymmetry, and to improve the efficiency of chain Governance.
Intertextuality in the Construction of Christopher Robin
Authors: Barros Ana Carolina Gregol de , Silva Cristina Ennes da
Published: November 2024

Objective: The objective of this study was to analyze the role of intertextuality in the construction of the film narrative to aesthetically bring it closer to or distance it from the Winnie the Pooh books, created by A.A. Milne and illustrated by E.H. Shepard.
 
Theoretical Framework: The investigation is based on the conceptions of dialogism introduced by Bakhtin (2009) and intertextuality studies by Kristeva (2012) and Genette (2009; 2010). Additionally, it incorporates intertextuality concepts from Jenny (1979), language theories from Burke (1966) and Hall (1997), film adaptation studies by Stam (2008), and cinematic narrative concepts from Aumont et al. (2007) and Gaudreault (2009).
 
Method: The methodology employed in this research is characterized as descriptive, bibliographic, and documental, with a qualitative approach and content analysis based on Bardin (2011).
Results and Discussion: The investigation revealed an intertextual dialogue between the film and the book, making the film credible in relation to the literary works published.
 
Research Implications: The research proposes an intertextual dialogue between film and book, showing how each benefits from the other in adaptations.
 
Originality/Value: The study provides an academic contribution by exploring intertextuality as a tool in the creation of film narratives, highlighting its role in the adaptation and reinvention of stories.
The effect of a new product based on quercetin and a thick extract of carrot seed root on the histological state of the rat cardiac muscle in the adrenaline-hydrocortisone-induced myocardial infarction
Authors: Kononenko T. R. , Chikitkina V. V.
Published: November 2024

Aim. To study the effect of tablets with a thick extract of carrot seed root and quercetin on the histological state of the rat cardiac muscle in the experimental adrenaline-hydrocortisone-induced myocardial infarction.
Materials and methods. The cardioprotective effect of tablets with a thick extract of carrot seed root and quercetin was studied on the model of acute adrenaline-hydrocortisone-induced myocardial infarction caused by subcutaneous administration of 0.1 % adrenaline hydrochloride solution in the dose of 1 mg/kg and 2.5 % hydrocortisone acetate emulsion in the dose of 12.5 mg/kg of the animal weight twice daily for a week. The tablets under research in the dose of 200 mg/kg and the reference drugs – “Thiotriazolin” and “Cratal” tablets were administered for 14 days – 7 days before the infarction modeling and 7 days of the myocardial infarction development, after which their effect on the histological state of the rat heart muscle was studied.
Results. Modeling of the adrenaline-hydrocortisone-induced myocardial infarction in rats is accompanied by the appearance of focal necrotic changes in muscle cells, which in some cases are accompanied by initial regenerative manifestations in the form of granuloma formation; dystrophic processes of cardiomyocytes. The therapeutic and prophylactic administration of tablets from a thick extract of carrot seed root and quercetin on the model of the adrenaline-hydrocortisone-induced myocardial infarction has the cardioprotective effect, reducing the severity of necrotic and dystrophic changes in the cardiac muscle.
Conclusions. As a result of modeling of the adrenaline-hydrocortisone-induced myocardial infarction in rats, focal necrotic changes in muscle cells were observed, sometimes accompanied by the initial formation of a matrix consisting of young fibroblasts; dystrophic processes of cardiomyocytes, in particular myocytolysis, fluctuations in the size of nuclei. The therapeutic and preventive administration of the tablets studied on the model of the adrenaline-hydrocortisone-induced myocardial infarction has the cardioprotective effect, reduces the severity of necrotic and dystrophic changes in the cardiac muscle. By the cardioprotective effect expressiveness, tablets with a thick extract of carrot seed root and quercetin on the model of the adrenaline-hydrocortisone-induced myocardial infarction are not inferior to the reference drugs – “Thiotriazolin” and “Cratal” tablets. The results experimentally substantiate the feasibility of creating a new combined drug from a thick extract of carrot seed root and quercetin for the prevention and pharmacocorrection of a cardiovascular pathology.
Interaction of Boundary Layer and Suction Chamber of a Laminarization System
Authors: von Soldenhoff Richard , Lüdeke Heinrich
Published: November 2024

To investigate the interaction of Tollmien–Schlichting instabilities in a boundary layer over a porous surface with an underlying suction chamber, two-dimensional simulations solving the complete Navier–Stokes equations are conducted. It is found that the coupling of disturbances in the boundary layer and in the chamber leads to an increased mode amplification. The additional growth rate depends on the pore geometries, more generally on the impedance of the porous surface. It is shown that the amplitude growth is not dependent on the suction flow through the pores, assuming the boundary layer profile remains constant. This is realized by the use of source terms in the boundary layer. Furthermore, it is demonstrated that partitioning the chamber can mitigate the additional amplification. In this case, disturbances are prevented from propagating inside the suction chamber.
Patient perspectives on living with chronic myeloid leukemia in India: Quality of life, psychosocial support, and stigma
Authors: Sarangi Satya Sadhan , Yadav Rajan , Singh Romya
Published: November 2024

Chronic myeloid leukemia (CML) stands a frequently encountered type of blood cancer. Despite advancements in treatment, CML patients in India encounter obstacles in accessing healthcare and managing treatment-related side effects. This review focuses on understanding the experiences of patients living with CML in India. It delves into various aspects, such as their quality of life, the psychosocial support they receive, and the stigma they might face due to their condition. Psychological, emotional, and financial burdens are significant, compounded by limited social support and stigma. Coping strategies and psychosocial interventions play crucial roles in addressing these challenges. In addition, the review underscores the importance of patient-centred care and advocacy in enhancing outcomes and addressing unmet needs in CML management. Understanding the experiences of patients living with CML informs strategies for improving healthcare services and support systems to ensure holistic care and a better quality of life for patients.
Molecular Mechanisms of Aerosol Nucleation: from CLOUD Chamber Experiments to Field Observations
Authors: Dada Lubna , Huang Wei , El-Haddad Imad
Published: November 2024

Atmospheric aerosol particles contribute to over four million premature deaths annually and play a critical role in modulating Earth’s climate. Most atmospheric particles and more than 50% of the cloud condensation nuclei are formed through a secondary process named new particle formation involving unique precursor vapors. This article summarizes current knowledge of how new atmospheric particles form, based on experiments at the CERN CLOUD chamber. While the role of sulfuric acid has long been known, other vapors like highly oxygenated organic molecules and iodine oxoacids are also important, along with stabilizers like ammonia, amines, and ions from cosmic rays. We explain how findings from CLOUD experiments help us understand particle formation in various atmospheric conditions and improve air quality and climate models.
Unveiling the Implicit: Arctic Coastal Aerosol Processes
Authors: Schmale Julia , Heutte Benjamin , Dyson Joanna
Published: November 2024

Arctic coasts cover more than 101,000 km and emulsify terrestrial, marine and socio-economic ecosystems. All three components produce specific emissions that contribute to the mix of atmospheric constituents, which are processed and dispersed in the coastal atmosphere to contribute to cloud formation through cloud condensation nuclei and ice nucleating particles. Clouds strongly influence the coastal energy balance. Importantly, Arctic coastal ecosystems are exposed to multiple pressures such as the warming atmosphere and ocean, the thawing cryosphere and the expanding anthropogenic activities. This means that coastal emissions and atmospheric processes are in constant evolution. Given the large area covered by coasts and the mix of emission sources, coastal aerosol processes deserve quantification to better understand their role in accelerated Arctic climate change.
Multiphase Chemistry in the Atmosphere
Authors: Ammann Markus , Alpert Peter A. , Artiglia Luca , Bao Fengxia , Bartels-Rausch Thorsten , Flórez Ospina Juan Felipe , Garner Natasha M. , Iezzi Lucia , Kilchhofer Kevin , Laso Andrés , Longetti Luca , Mahrt Fabian
Published: November 2024

Earth’s atmosphere comprises a complex mix of gas and condensed phases, where condensed phases facilitate multiphase chemical reactions that would not occur in the gas phase alone. These reactions drive dynamic physical and chemical processes across various spatial and temporal scales, playing a crucial role in the cycling of atmospheric trace constituents. Multiphase chemistry significantly influences geochemical cycles, human health, and climate. This review focuses on the chemical steps governing the cycling of important species, such as halogens, reactive nitrogen, and organics, within aerosol particles, a key type of atmospheric condensed phases, and at condensed phase–air interfaces. These interfaces include mineral oxides, ice, and aqueous solutions found in particulate matter, clouds, snow, and on oceanic and terrestrial surfaces. This review also discusses the important role of redox chemical cycling, the hydrogen bonding network and water activity in these processes.
Unraveling Microbial Effectors: Metaproteomics in the One Health Framework
Authors: Heyer Robert , Wolf Maximilian , Benndorf Dirk , Uzzau Sergio , Seifert Jana , Grenga Lucia , Pabst Martin , Schmitt Heike , Mesuere Bart , Van Den Bossche Tim , Haange Sven-Bastiaan , Jehmlich Nico , Di Luca Mariagrazia , Ferrer Manuel , Serrano-Villar Sergio , Armengaud Jean , Bode Helge , Hellwig Patrick , Masselot Catherine Robbe , Léonard Renaud , Wilmes Paul
Published: November 2024

One Health seeks to integrate and balance the health of humans, animals, and environmental systems. These three spheres are intricately interconnected through microbiomes, which are universally present and exchange microbes and genes, influencing not only human and animal health but also key environmental, agricultural, and biotechnological processes. Preventing the emergence of pathogens as well as monitoring and controlling the composition of microbiomes through microbial effectors including virulence factors, toxins, antibiotics, non-ribosomal peptides, and viruses holds transformative potential. However, the mechanisms by which these microbial effectors shape microbiomes and their broader functional consequences in relation to host and ecosystem health remain poorly understood to date. Metaproteomics offers a novel methodological framework as it provides insights into microbial dynamics by quantifying microbial biomass composition, metabolic functions and detecting effectors like viruses, antimicrobial resistance proteins, and non-ribosomal peptides. Here, we document the potential of metaproteomics for elucidating microbial effectors and their impact on microbiomes, and discuss their potential for modulating microbiomes to foster desired functions.
Copper(I) Bis(diimine) Sensitized Titania Nanotube Array Photoelectrodes for Photoelectrochemical Water Oxidation
Authors: Chiong Joseph , Singh Zujhar , Ricardo-Noordberg Joseph , Nguyen Nhat Truong , Majewski Marek
Published: November 2024

Dye-sensitized photoelectrochemical cells (DS-PECs), devices inspired by photosynthesis, are being developed to advance the goal of using the sun as the sole source of energy for converting abundant resources to fuel and valuable chemicals. Herein, we report using compact and vertically aligned titanium dioxide nanotubes as semiconducting materials functionalized with a molecular copper(I) bis(diimine)-based donor-chromophore-acceptor to yield a photoanode capable of carrying out oxidative processes. Surface characterization and photoelectrochemical studies point to the nanotubes being intrinsically sensitized with carbon impurities for visible light absorption. The ability of unfunctionalized and dye-sensitized photoanodes to drive oxidative processes is further confirmed photoelectrochemically and in the presence of a water oxidation catalyst where a Faradaic efficiency of 84% is found for oxygen production.
A High-Level Adaptation Toolkit for Unified Integration of Software Systems with Neural Interfaces
Authors: Chuprina S.I. , Labutin I.A.
Published: November 2024

The paper is devoted to the urgent problem of automating the process of integrating different types of neurointerfaces into the infrastructure of the Internet of Things. Due to the low-level nature of these devices and related tools, integrating neurointerfaces with a wide range of IoT devices is a complex task requiring specialized knowledge and skills in the fields of neuroscience and signal processing. To tackle the significant challenge of automating such kind integration we continue to improve our previously proposed ontology-driven methods and tools for seamless integration of software systems with neural interfaces in a unified way. The presented notable improvements include the introduction of a new data processing pipeline that utilizes a portable device to validate the effectiveness of the system and the development of an intuitive graphical user interface enabling real-time data visualization facilities that provides an easy and understandable feedback.
3D Model of the Winding Product
Authors: Tomilova O. V. , Rokotov N. V.
Published: November 2024

The article presents the results of computer modeling of a winding product. It describes the method for creating a 3D model based on a series of flat sections passing through the axis of the package. The issues encountered during 3D modeling and their solutions are discussed. The authors propose using the continued fraction method to describe the structure of winding products and optimize the model for subsequent calculations in CAE programs. The article provides information about the process of creating a 3D model of the winding product, as well as the possibilities for reducing computational resources required for modeling. The results of computer modeling of various winding types are presented. In the conclusion, the authors assert that the developed method for analyzing and synthesizing the structure of precision winding using the continued fraction approach allows for the exploration of various winding types and the creation of optimal 3D models that replicate their structure. These models can be used for further research and as digital models of winding products.
Regulatory Aspects and Practical Approaches to Data Visualization
Authors: Maksimenko L. A.
Published: November 2024

The article examines the role and importance of data visualization in the modern information society. The regulatory aspects of the application of the visualization method are considered, including issues of classification, security, confidentiality and ethics of data use. Special attention is paid to the use of visualization techniques to work with open information and open data to present graphs, charts, big data, datasets, dashboards and interactive reports. When perorming the work, the ESCD and SPDS standards were taken into account, containing rules and recommendations for the graphic design of objects; BI tools for creating dashboards were considered. At the same time, it is emphasized that modern trends in digitalization and automation put forward additional requirements for information processing, which can be interpreted as a new stage in the field of data visualization.
“There was a house here. There were two houses there.” Oral history as a source for the reconstruction of displaced Lemko/Rusyn villages on the example of Biała Woda
Authors: Federyga Kamil , Cieplak Dominika
Published: November 2024

Using the example of the abandoned Rusyn village of Biała Woda, an attempt was made to involve oral history in the process of space reconstruction, while demonstrating the close connections of memory and place. Through the analysis of an interview with a former resident of the village and comparison with historical sources and press articles, the history of key locations for the pre-displacement village layout, such as the school, mill and lime kiln, was recreated. Thus, the potential of using oral history in protecting the heritage of repressed national and ethnic minorities is presented.
LA ECONOMÍA CIRCULAR COMO OPCIÓN DE DESARROLLO ECONÓMICO LOCAL EN CUBA
Authors: Nodarse Hiram Marquetti
Published: November 2024

El desarrollo local representa en las condiciones actuales una de las principales prioridades gubernamentales, en tanto se pretende mediante esta proyección, no solo avanzar con mayor celeridad en el desarrollo de las fuerzas productivas, sino también en la búsqueda de respuestas efectivas a diferentes restricciones que enfrentan los territorios y la totalidad de la nación. Mientras que la economía circular ha ido ganando mayor protagonismo, como opción para enfrentar la compleja
situación económica que enfrenta el país. En pro de avanzar en este tema desde 2012 se adoptó una política dirigida a priorizar la problemática del reciclaje, en 2020 se formuló la política de desarrollo de industrial que incorpora con fuerza el tema del reciclaje, al tiempo que pretende incorporar con mayor intensidad la concepción de la economía circular en múltiples áreas de
la economía.
LA DESCENTRALIZACIÓN Y AUTONOMÍAS EN EL ECUADOR: UN MODELO EN RIESGO INMINENTE
Authors: Dávalos Aguilar Lenin Pablo
Published: November 2024

El presente texto parte de la hipótesis de que el programa de consolidación fiscal del FMI y el esquema de descentralización del Estado y régimen de autonomías son incompatibles. Para que uno de ellos subsista el otro debe desaparecer. Para ello se describe el funcionamiento legal de la descentralización y el régimen de autonomías y, luego, se identifican las reformas
que alteran las autonomías e integran a los Gobiernos Autónomos Descentralizados (GAD), al sistema de contabilidad del gobierno central a través del concepto de Sector Público No Financiero. Se concluye con la advertencia que el modelo de descentralización y autonomías está en riesgo.