bluuebunny/crossref_metadata_2025 huggingface dataset:
The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging
Authors: Smith Lydia M. , Greenwood Hannah E. , Tyrrell Will E. , Edwards Richard S. , de Santis Vittorio , Baark Friedrich , Firth George , Tanc Muhammet , Terry Samantha Y. A. , Herrmann Anne , Southworth Richard , Witney Timothy H.
Published: November 2023

Mouse models are invaluable tools for radiotracer development and validation. They are, however, expensive, low throughput, and are constrained by animal welfare considerations. Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging studies. NCI-H460 FLuc cells grown in Matrigel on the CAM formed vascularized tumors of reproducible size without compromising embryo viability. By designing a simple method for vessel cannulation it was possible to perform dynamic PET imaging in ovo, producing high tumor-to-background signal for both 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and (4S)-4-(3-18F-fluoropropyl)-L-glutamate (18F-FSPG). The pattern of 18F-FDG tumor uptake were similar in ovo and in vivo, although tumor-associated radioactivity was higher in the CAM-grown tumors over the 60 min imaging time course. Additionally, 18F-FSPG provided an early marker of both treatment response to external beam radiotherapy and target inhibition in ovo. Overall, the CAM provided a low-cost alternative to tumor xenograft mouse models which may broaden access to PET and SPECT imaging and have utility across multiple applications.
Advances in NMR spectroscopy of small molecules in solution
Authors: Nolis Pau
Published: November 2023

This book chapter covers relevant articles published in peer-reviewed journals in 2022 in the field of NMR spectroscopy of small molecules in solution. Articles that appeared in 2022 as accepted online versions but not published in the journal’s issue are not included. The chapter is structured into six sections: NMR pulse sequence development, structural determination in oriented media, mixture analysis, quantitative NMR, NMR chiral recognition methodologies and machine learning in NMR. Even though many articles could fit in more than one section, since most of the topics are intimately related. A short and concise introduction of each section is given, but the reader should not expect a fully detailed review, nor a simple, non-detailed listing of articles. Instead, the reader shall find distilled information with the key points, the main goals, and a personal interpretation of the success of the reported articles.
Ultrasensitive fluorescence immunoassay of pepsinogen I based on enzyme-triggered decomposition of AuNCs/MnO2
Authors: Zhang Huanzong , Cai Binhuang , Cai Fan , Lian Mingzhe , Wang Yinghui
Published: November 2023

This work developed a fluorescence immunoassay for the detection of pepsinogen I using gold nanocluster-anchored manganese dioxide nanosheets.
Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels
Authors: Liu Zuolong , Zhou Xianchi , Chen Yongcheng , Ni Yanwen , Zhu Zihao , Cao Wenzhong , Chen Kexin , Yan Yu , Ji Jian , Zhang Peng
Published: November 2023

We present a biocompatible, controllably degradable, and functionalizable zwitterion-albumin hybrid hydrogel with long-term resistance against foreign body responses.
Using natural language processing (NLP)-inspired molecular embedding approach to predict Hansen solubility parameters
Authors: Pang Jiayun , Pine Alexander W. R. , Sulemana Abdulai
Published: November 2023

Hansen solubility parameters can be predicted with good accuracy using only the SMILES of molecules and a BERT deep learning model with finetuning.
Insights into Pyrocumulus aerosol composition: black carbon content and organic vapor condensation
Authors: Gorkowski Kyle , Koo Eunmo , Jordan Spencer , Reisner Jon , Benedict Katherine B. , Dubey Manvendra
Published: November 2023

Megafires are increasingly generating Pyrocumulus clouds (PyroCus) through the interplay of atmospheric conditions such as stability and humidity, hot updrafts, and emitted aerosols from burning vegetation.
Bifidobacterium animalis subsp. lactis boosts neonatal immunity: unravelling systemic defences against Salmonella
Authors: Lin Chunxiu , Lin Yugui , Wang Shunhe , Wang Jialiang , Mao Xuhua , Zhou Yonghua , Zhang Hao , Chen Wei , Wang Gang
Published: November 2023

Bifidobacterium animalis subsp. lactis pretreatment coordinately regulates colonic and serum metabolites, influencing the systemic immune responses of neonatal rats to Salmonella infection.
Cocatalyst-modified In2S3 photocatalysts for C–N coupling of amines integrated with H2 evolution
Authors: Chen Yu , Tan Chang-Long , Li Jing-Yu , Qi Ming-Yu , Tang Zi-Rong , Xu Yi-Jun
Published: November 2023

The dual function of visible-light-driven cooperative production of imine and H2 is realized on oxidative cocatalyst PdS-modified In2S3 nanospheres, which fully utilizes the synergistic potential of the photoredox system.
An in-sensor humidity computing system for contactless human–computer interaction
Authors: Qi Meng , Xu Runze , Ding Guanglong , Zhou Kui , Zhu Shirui , Leng Yanbing , Sun Tao , Zhou Ye , Han Su-Ting
Published: November 2023

Respiratory detection and contactless human–computer interaction capacity is achieved by a humidity-sensitive memristor.
Overview of solar thermal applications of heat exchangers with thermophysical features of hybrid nanomaterials
Authors: Khan Muhammad Naveed , Aldosari F. M. , Wang Zhentao , Yasir Muhammad , Afikuzzaman Mohammad , Elseesy Ibrahim E.
Published: November 2023

With their notable thermal characteristics, fluids incorporating nanoparticles have significant importance in industrial processes.
Biogenic synthesis of novel nanomaterials and their applications
Authors: Chormey Dotse Selali , Zaman Buse Tuğba , Borahan Kustanto Tülay , Erarpat Bodur Sezin , Bodur Süleyman , Tekin Zeynep , Nejati Omid , Bakırdere Sezgin
Published: November 2023

Synthesis of nanoparticles of different shapes and sizes using biological precursors and their applications.
Impedance spectroscopy of Sb2Se3 photovoltaics consisting of (Sb4Se6)n nanoribbons under light illumination
Authors: Park Jaemin , Shalvey Thomas P. , Moehl Thomas , Woo Kyoohee , Major Jonathan D. , Tilley S. David , Yang Wooseok
Published: November 2023

Impedance spectroscopy characterization was performed under light illumination with Sb2Se3 photovoltaics having two different (Sb4Se6)n nanoribbon orientations.
Contemporary innovations in two-dimensional transition metal dichalcogenide-based P–N junctions for optoelectronics
Authors: Elahi Ehsan , Ahmad Muneeb , Dahshan A. , Rabeel Muhammad , Saleem Sidra , Nguyen Van Huy , Hegazy H. H. , Aftab Sikandar
Published: November 2023

Two-dimensional transition metal dichalcogenides (2D-TMDCs) with various physical characteristics have attracted significant interest from the scientific and industrial worlds in the years following Moore's law.
A polymeric iron oxide nanocomplex loaded with sulfasalazine: an approach for inducing ferritinophagy-assisted ferroptosis for anti-cancer therapy
Authors: Lim Junha , Lee Junseok , Boo Yeonju , Kim Won Jong
Published: November 2023

A ferritinophagy-assisted ferroptosis strategy addresses the limitations in iron-based anti-cancer therapy by inhibiting GSH, inducing ferritin degradation, overloading labile iron ions, and enhancing ferroptosis.
Coulomb interactions for mediator-enhanced sensitized triplet–triplet annihilation upconversion in solution
Authors: Glaser Felix , Schmitz Matthias , Kerzig Christoph
Published: November 2023

An energy transfer cascade in a three-component upconversion system improves the emission quantum yield and reduces intrinsic filter effects. Investigations of molecular interactions are combined with lab-scale applications in photocatalysis.
Correction: Pursuing colloidal diamonds
Authors: Baran Łukasz , Tarasewicz Dariusz , Kamiński Daniel M. , Rżysko Wojciech
Published: November 2023

Correction for ‘Pursuing colloidal diamonds’ by Łukasz Baran et al., Nanoscale, 2023, 15, 10623–10633, https://doi.org/10.1039/D3NR01771K.
Solid-state NMR chemical shift analysis for determining the conformation of ATP bound to Na,K-ATPase in its native membrane
Authors: Middleton David A. , Griffin John , Esmann Mikael , Fedosova Natalya U.
Published: November 2023

Solid-state NMR and DFT 13C chemical shift calculations are used to determine the ribose ring conformation of hydrolysable adenosine 5′-triphosphate when freeze-trapped in the high-affinity binding site of Na,K-ATPase.
Palladium-anchored donor-flexible pyridylidene amide (PYA) electrocatalysts for CO2 reduction
Authors: Khurshid Afshan , Tanveer Tania , Hafeez Komal , Ahmed Maqsood , Akhtar Zareen , Zafar M. Naveed
Published: November 2023

Pd-PYA complexes as carbon dioxide reduction catalysts.
Dye-sensitized solar cells based on highly catalytic CNTs/Ti3C2Tx MXenes composite counter electrode
Authors: Hu Zishan , Li Yuanlin , Li Aijun , Wang Hai-Hua , Wang Xiao-Feng
Published: November 2023

Establishing stable and efficient Pt-free counter electrodes (CEs) is an important challenge for dye-sensitized solar cells (DSSCs).
A library of vinyl phosphonate anions dimerize with cyanostars, form supramolecular polymers and undergo statistical sorting
Authors: Chen Yusheng , Kuvayskaya Anastasia , Pink Maren , Sellinger Alan , Flood Amar H.
Published: November 2023

Stacking the deck in our favor. We make a single suit of anions with different faces but all assembling the same way inside cyanostars. With this strong hand, we play two cards together to form a supramolecular copolymer and beat solubility.
In situ studies of reversible solid–gas reactions of ethylene responsive silver pyrazolates
Authors: Dias H. V. Rasika , Parasar Devaborniny , Yakovenko Andrey A. , Stephens Peter W. , Muñoz-Castro Álvaro , Vanga Mukundam , Mykhailiuk Pavel , Slobodyanyuk Evgeniy
Published: November 2023

In situ chemistry of solid silver pyrazolates with ethylene gas, depending on the pyrazolyl ring substituents, stops at a trinuclear complex or leads to complete structure re-organizations producing dinuclear complexes as evident from PXRD data.
A ZnO&GeSe composite electron transport layer for organic solar cells
Authors: Tan Jingyu , Li Hongye , Sun Yapeng , Li Guanliang , Zhao Yujun , Yu Huangzhong
Published: November 2023

The deposition of 2D GeSe on the surface of ZnO improves the surface stability of ZnO and reduces the probability of forming defect vacancies on the surface of ZnO, thereby achieving high photoelectric conversion efficiency.
Synthesis of Cu1Mg3Sc2(OH)12CO3 layered double hydroxide and its derived catalyst for hydrogenation of DMCD to CHDM
Authors: Chang Zhili , Ye Boyong , Zhong Zixin , Wang Songlin , Wang Han , Du Weichen , Hou Zhaoyin
Published: November 2023

The Cu1/Mg3Sc2O6 catalyst was extremely active and stable for the hydrogenation of DMCD to CHDM under mild conditions.
ADOR zeolite with 12 × 8 × 8-ring pores derived from IWR germanosilicate
Authors: Yue Qiudi , Kasneryk Valeryia , Mazur Michal , Abdi Sarra , Zhou Yong , Wheatley Paul S. , Morris Russell E. , Čejka Jiří , Shamzhy Mariya , Opanasenko Maksym
Published: November 2023

Addressing the synthesis–property relations in the Assembly step of ADOR enabled to design previously unknown IPC-17 zeolite by optimization of the chemical composition and crystallite dimensions in the parent IWR germanosilicate.
Correction: Designer hydrogenated wrinkled yolk@shell TiO2 architectures towards advanced visible light photocatalysts for selective alcohol oxidation
Authors: Ziarati Abolfazl , Badiei Alireza , Luque Rafael , Ouyang Weiyi
Published: November 2023

Correction for ‘Designer hydrogenated wrinkled yolk@shell TiO2 architectures towards advanced visible light photocatalysts for selective alcohol oxidation’ by Abolfazl Ziarati et al., J. Mater. Chem. A, 2018, 6, 8962–8968, https://doi.org/10.1039/C8TA02012D.
Polyarylether-based COFs coordinated by Tb3+ for the fluorescent detection of anthrax-biomarker dipicolinic acid
Authors: Liu Yinsheng , Wang Mingyue , Hui Yinfei , Sun Lei , Hao Yanrui , Ren Henlong , Guo Hao , Yang Wu
Published: November 2023

In this study, a rare-earth hybrid luminescent material (lanthanide@COF) was constructed for the detection of a biomarker for anthrax (dipicolinic acid, DPA).
Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances
Authors: Hu Shumeng , Zhao Runan , Xu Yu , Gu Zelin , Zhu Beiwei , Hu Jiangning
Published: November 2023

Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that results in inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis and Crohn's disease.
Design of chemosensors and dynamic anticounterfeiting inks based on colloidal nanoprecipitated polymers
Authors: Babazadeh-Mamaqani Milad , Alipour-Fakhri Sana , Mohammadi-Jorjafki Moein , Roghani-Mamaqani Hossein , Mardani Hanieh , Babaie Amin
Published: November 2023

Fluorescent polymer nanoparticles, prepared by physical incorporation of fluorescein during the nanoprecipitation of the polymers, showed applications in high-level anticounterfeiting and chemical sensing of pH, CO2, and acidic and basic vapors.
Spin-crossover tuning of the luminescence in 2D Hofmann-type compounds in bulk and exfoliated flakes
Authors: García-López Víctor , Marques-Moros Francisco , Troya José , Canet-Ferrer Josep , Clemente-León Miguel , Coronado Eugenio
Published: November 2023

Two Hofmann-type multifunctional materials are reported, displaying a tuning of the luminescence properties by the spin-crossover, and have exfoliated by in nanometric flakes by the Scotch-tape method.
Charge storage kinetics of interconnected MnO2 nano-needles/reduced graphene oxide composite for high energy density quasi-solid-state sodium ion asymmetric supercapacitor
Authors: Jhankal Deependra , Khan Mohammad Saquib , Shakya Preeti , Bhardwaj Nikita , Yadav Bhanu , Jhankal K. K. , Sachdev K.
Published: November 2023

A facile synthesis route for preparing manganese dioxide (MnO2) with unique nano-needle morphology and its nanocomposite with reduced graphene oxide (MnO2–rGO) for high energy density quasi-solid-state asymmetric supercapacitor.
Analysis of the pre-service physics teacher’s ability to develop SDGs-oriented multimedia
Authors: Kholiq Abd , Sucahyo Imam , Anggaryani Mita , Satriawan Muhammad , Habibbulloh Muhammad
Published: November 2023

The teacher’s ability to develop multimedia is one of the supporting factors in communicating physics learning. Besides that, another requirement for a teacher is to introduce the concept of SDGs to students to prepare generations to achieve sustainable development goals for a better future. Therefore, this study aimed to analyze the abilities of pre-service physics teachers in developing SDGs-oriented multimedia. This study is descriptive research on the pre-service physics teacher who joined multimedia lectures in the Physics Education study program at one of the state universities in Surabaya, Indonesia. Data was collected through interviews and using product assessment sheets, then analyzed descriptively. Based on the results of data analysis, of the six indicators of the ability to develop multimedia, only two indicators were in the high category, namely the ability to edit videos and Accurate presentation of SDG content, and one indicator in a low category was ability to present animations, while the others three in the medium category. Therefore, it can be concluded that preservice physics teachers’ ability to develop SDGs-oriented multimedia is in the medium category.
Automatic shoe embossing machine integrated with real-time data cloud system to improve SMEs footwear productivity
Authors: Iskandar  , Arsana I. Made , Pambudi Rizdana Galih , Nugroho Yuli Sutoto , Syahputra Muhammad Febrilian Dwi
Published: November 2023

The primary function of the automatic shoe embossing machine integrated with a real-time data cloud system is to enhance the shoe manufacturing process by imprinting designs onto leather shoes, while simultaneously collecting and transmitting production data for monitoring and analysis. This research project aims to design and develop a cuttingedge shoe embossing machine. To achieve this, we employ a Raspberry Pibased cloud system to gather and store production data in a database format, allowing for real-time monitoring and operator feedback. The research methodology encompasses several stages, including design, manufacturing, assembly, operational testing, performance evaluation, and data analysis. In conclusion, this research project demonstrates the successful development of an automatic shoe embossing machine integrated with a real-time data cloud system. This innovation streamlines the shoe manufacturing process, ensuring high-quality embossing while providing valuable real-time production data for enhanced control and decision-making.
Automatic patient bed comfort structure analysis based on the RULA method
Authors: Dzulkiflih  , Utomo Wahyu Mulyo , Paramita Sista , Anifah Lilik , Budijono Agung Prijo , Umaroh Susi Tri
Published: November 2023

To improve patient care, reduce medical staff injuries, and increase the efficiency of the patient care process, automated patient beds are a very important innovation in the world of healthcare. However, there needs to be a study to find an ergonomic automatic bed design so that it is safe and comfortable when used by patients. This research concerns the study of the ergonomics of patient bed design using the Rapid Upper Limb Analysis (RULA) method. The patient bed that has been designed is then analyzed using RULA to obtain initial ergonomic data from a designed patient bed. There are 3 observations made, namely the patient’s condition when sitting, the patient’s condition when lying down, and the patient’s condition when the bed can be adjusted low. When in the sitting position, the average RULA result is obtained at 3, when lying down, the average RULA result is obtained at 3, and when the bed is set low, the average RULA result is obtained at 3. This ergonomic value is an accumulation of the assessment of the structure of the upper arms and forearms, lower body, muscles, neck, torso, legs, wrists, and arms.
Machine learning on academic education: Bibliometric studies
Authors: Tjahyaningtijas Hapsari Peni Agustin , Husin Nanang , Al Habib Hasanuddin , Asmunin Asmunin , Wibawa Rindu Puspita , Sumarno Alim , Paragas Jesse R. , Susantini Endang
Published: November 2023

The use of Machine Learning exhibits significant promise in facilitating advancements in the field of education. It is vital to conduct a comprehensive review of existing research to ascertain the significance of utilizing Machine Learning as a viable approach to enhance educational advancements. This bibliometric analysis provides a comprehensive overview of the advancements in the application of machine learning techniques within the field of education. This study utilizes publication and citation data from many academic literature sources to elucidate prominent patterns, areas of research emphasis, and scholarly collaborations within this field. The findings of the bibliometric analysis reveal a significant increase in scholarly attention toward the application of machine learning in the field of education during the past several years. The scope of these investigations encompasses a diverse array of subjects, such as personalized learning, predictive analytics, automated evaluation, learning recommendations, and online exam proctoring. The findings of this study also demonstrate a notable rise in the level of collaboration among scholars from many fields, highlighting the significance of interdisciplinary approaches in tackling the intricate challenges associated with the integration of machine learning in education.
Plastic Waste Reduction Strategy in Bogor City, Indonesia
Authors: Ratnawati Beata , Sulistijorini Sulistijorini , Sholihah Walidatush , Aziezah Nur , Tribuana Tunggadewi Andini , Samiaji Dimas , Johana Ginting Keyren
Published: November 2023

Plastic waste is a problem in the city/district. Plastic waste cannot be decomposed so it needs special efforts in plastic waste management. The purpose of this study was to determine the plastic waste management strategy in Bogor City. The research was conducted in Bogor City from September to November 2022. Research data were obtained from interviews with waste managers and direct measurement of waste for 8 consecutive days. The data obtained were analyzed descriptively and quantitatively. From the results of waste measurement, it was found that plastic waste generated in Bogor City is around 2- 29%. Plastic waste reduction strategies are the existence of regulations from the government, waste reduction using reuse, reduce, and recycle.
In-situ growth of zeolite-A in the fiber surface for methane adsorption
Authors: Amalia Sholeha Novia , Urip Pambudi Sujarnoko Tekad , Alyaa Shofaa Eryaputri Nyi Raden , Farobie Obie , Masruchin Nanang , Susanti Indri , Wijiyanti Rika , Sahida Binti Hassan Nurul , Muhamad Iqbal Rendy , Widiastuti Nurul
Published: November 2023

Methane as an anthropogenic gas has an effect on the atmosphere and can be used as an alternative natural gas using adsorbent material. This research aims to determine the impact of activation conditions on the surface of fibers for zeolite-A crystal growth utilized for CH4 adsorption. Glass fiber and pineapple fiber have been treated with an alkali used in this research. The concentration of NaOH and fiber immersion time determine the activation conditions. The activation process altered the crystallinity of the surface-deposited zeolite-A. Characterization by XRD and SEM revealed that zeolite-A covered the surface of those fibers when the NaOH concentration was 4M and the immersion time was 24 h. Thermal analysis revealed that the composite of zeolite-A/fibers undergoes two weight loss processes prior to achieving stability. The methane adsorption gravimetric measurements for zeolite-A supported glass fiber (glass wool) and pineapple fiber with high crystallinities are 4.644% wt and 3.461% wt, respectively.
Development of an IOS-Based Baby Meal Planner Application
Authors: Rizkiriani Annisa , Dianah Rosyda , Kartinawati Annisa
Published: November 2023

The Baby Meal Planner (BMP) application has been developed by the authors since 2020, and in 2022 BMP version 2.0 has been redeveloped. The BMP Version 2.0 application has been equipped with a cut-off point for the baby’s nutritional status with the latest references, calculation of energy and nutrient needs for babies up to 24 months of age, calculation of food needs for MPASI up to 24 months of age, and is equipped with MP-ASI recipes for up to 24 months of age. 24 months. Currently, the Android version of the BMP application has been used by more than 5,000 people, received a rating of 4.9, has 3 copyright certificates, has been published in SINTA-indexed journals, has been processed in international journal reviews, and has been reached to the public in community service activities. Along with the increase in smartphone users with the iPhone Operating System (IOS) operating system, the purpose of this research is to develop an IOSbased Baby Meal Planner Application. The research will be carried out for 8 months from April to December 2023, in collaboration with the Kebon Kalapa Village, Central Bogor District, Bogor City through the PKK and Posyandu as partners in the research. Research activities consist of a preparatory process in the form of discussion activities with partners, licensing, and preparation of proposals. Application development activities include developing application features, processing complementary food menus, and outreach to the community. The method used in application development is the Forward Chaining Method. The output of this study is the IOS-based Baby Meal Planner application, which can be downloaded from the App Store, with a level of technology readiness at level 7 (TKT 7).
Analysis of tourist motivation for traditional culinary tourism in Bogor
Authors: Bonanza Occy , Sofiantina Rahayu Kania , Prabandari Dyah , Patabang Melewanto , Lidya Leni
Published: November 2023

Bogor is a city that represents a blend of traditional Sundanese culture, colonial culture, and the modernity of a metropolitan city. A variety of culinary are offered, ranging from regional to traditional specialties. This condition encourages research on tourist motivation in traditional culinary tours in Bogor. Analysis of tourist motivation in traditional culinary tours can be the basis for developing culinary tourism areas in Bogor. The methods used in the research were observation, interviews, and questionnaires to 50 traditional culinary tourists from Bogor. The questionnaire contains the characteristics and motivations of tourists in culinary tours in Bogor. The collected data were analyzed using the Confirmatory Factors Analysis (CFA) statistical test. This study shows that the indicators of latent motivation have a significant and valid effect. Physical motivation, an indicator that reflects the condition of tourists in traditional culinary tourism activities, relieves fatigue. Furthermore, on cultural motivation, an indicator that reflects the condition of tourists is the desire to taste food. For social motivation, an indicator that reflects the condition of tourists is visiting family, and for status motivation, an indicator that reflects the condition of tourists is taking pictures at event venues/culinary activity centers.
Calculation cost of goods sold for edutourism package services using the full costing method at one home farm indonesia
Authors: Pratiwi Ratih , Ayu Azzahra Bilqis
Published: November 2023

One Home Farm is a farming community and one of the educational tourism destinations in the city of Bogor. Most tourist destinations have yet to charge optimal costs for the price of their tour packages so that the profits obtained are not optimal. The aim of this research is to identify costs and provide innovation in preparing educational tourism packages at one home farm. The data required is secondary data and primary data. Data collection techniques through documentation and interviews and data analysis were carried out descriptively. This research aims to determine the suitability of the basic price calculations carried out by one home farm with applicable accounting principles. The results show that One Home Farm has not applied general accounting principles in calculating the basic price of its educational tour packages. There are many costs that are not included in the selling price calculation.
Exploration of The Eco-Agro Tourism Perception as a New Environmental Paradigm Among The Urban Community in Tourism Village in Bogor City
Authors: Dewi Helianthi , Untari Rini , Rahmasari Liisa Firhani , Ratnawati Beata , Sartika Ika
Published: November 2023

The concept of eco-agrotourism is a new paradigm in managing tourist villages in Bogor City. Community perceptions about tourist villages are important to know to increase community participation and sustain the management of tourist villages. The research aims to analyze the potential of tourism resources, analyze community perceptions of the benefits of ecoagrotourism management, and analyze people’s perceptions of the impact of eco-agrotourism activities. The research was conducted in three tourist villages in Bogor City which represented dominant agricultural conditions, namely Saung Eling, Mulyaharja, and Rancamaya Tourism Villages. Primary data was collected by distributing questionnaires to community respondents and analyzed descriptively, as well as by using the Kruskal Wallis test. The research results show that people have high hopes for improving social and cultural life. The actual condition of tourism management shows that tourism management still needs to be improved so that economic improvement can be felt by the people in tourist villages. The development of eco-agrotourism needs to combine the potential of agricultural areas with cultural potential. Positive community’s perception can be increased by tourism management which can increase community participation and income.
Digital Marketing Application to the Coffee Marketing System at PT Bogor Kopi Indonesia
Authors: Br Sebayang Veralianta , Sahat Tua Manalu Doni , Suharno Suharno , Hasian Situmeang Widya
Published: November 2023

PT Bogor Kopi Indonesia is a company engaged in developing coffee farmers in the Bogor area and marketing coffee in the form of green beans and roasted beans. Every year, people’s coffee consumption continues to increase, so the demand for coffee continues to grow. In looking for a market to market its products, PT Bogor Kopi Indonesia applies digital marketing to the system forcing carried out. The company implements digital marketing through the company’s website and social media. In this case, PT Bogor Kopi Indonesia uses Instagram as a means to reach consumers. The purpose of this study is to determine the impact that occurs if PT Bogor Kopi Indonesia implements digital marketing in its marketing system and whether it has a positive effect on the company. The method used in this study is the Business Model Canvas (BMC) analysis method to make it easier to analyze the company’s situation and see changes that occur based on the nine blocks contained in the BMC method. The application of digital marketing at PT Bogor Kopi Indonesia has succeeded in building the trust of other companies to cooperate with the company; various content uploaded through social media attracts various parties to become consumers of PT Bogor Kopi Indonesia so this causes an increase in the company’s revenue.
Évolution ou révolution dans le traitement des dépressions avec la kétamine ?
Authors: Fossati Philippe
Published: November 2023

Définie par l’échec d’au moins deux antidépresseurs de mécanismes d’action différents, la dépression résistante est fréquente et concerne 30 % des patients déprimés. Elle justifie le recours à des stratégies thérapeutiques innovantes. Depuis quelques années, on utilise un agent anesthésiant et dissociatif, la kétamine, et ses dérivés, dans le traitement de la dépression résistante. Dans cette brève revue de la littérature, nous rapportons les données attestant de l’efficacité et de l’efficience de la kétamine dans cette indication. Certains patients bénéficient plus que d’autres de la kétamine qui est recommandée pour un niveau modéré de résistance. Même si cela reste débattu, la dissociation pourrait contribuer aux effets bénéfiques de la kétamine.
Quelle place pour l’expérimentation en éthologie ?
Authors: Kreutzer Michel
Published: November 2023

La démarche expérimentale est au centre de mes réflexions depuis mon baccalauréat « sciences ex ». Formé aux neurosciences, j’ai très vite choisi l’éthologie de terrain, pensant échapper à certaines démarches expérimentales et m’offrir des activités de recherche plus respectueuses de la vie animale. Aujourd’hui, je dois constater que cette option n’aboutit pas forcément à ce que j’avais imaginé. J’ai été à la fois le témoin et l’acteur de pratiques qui méritent attention. Ce parcours, jalonné par une évolution des conceptions de nos relations avec les être animés, me conduit à questionner les éthiques, parfois contradictoires, de l’action et de la connaissance.
Comment la kétamine peut-elle aider à mieux prendre en charge le risque suicidaire ?
Authors: Olié Emilie , Lengvenyte Aisté , Courtet Philippe
Published: November 2023

Les patients souffrant de dépression suicidaire répondent moins bien aux traitements antidépresseurs conventionnels que ceux qui n’ont pas d’idées suicidaires. Une avancée prometteuse dans ce domaine est l’utilisation de la kétamine, qui a montré une efficacité significative et rapide dans la réduction de l’intensité des idées suicidaires chez les patients déprimés. Des études ont montré qu’une seule perfusion intraveineuse de kétamine à faible dose pouva3it réduire de manière significative et durable les idées de suicide. De plus, la kétamine semble également réduire l’anhédonie, un symptôme associé aux idées suicidaires. Les mécanismes d’action de la kétamine sont multiples. Elle stimule la neuroplasticité via l’activation de la voie du BDNF (facteur neurotrophique du cerveau) et réduit l’inflammation. De plus, la kétamine semble agir sur le système opioïdergique, qui est impliqué dans les conduites suicidaires. En conclusion, la kétamine présente un intérêt dans la réduction des idées suicidaires chez les patients déprimés. Cependant, il est nécessaire de déterminer si son administration permet de prévenir les actes suicidaires. De plus amples recherches sont nécessaires pour mieux comprendre les mécanismes d’action de la kétamine et développer des stratégies thérapeutiques ciblées pour prévenir les conduites suicidaires.
Pour une bonne compréhension et un bon usage du terme « organoïdes »
Authors: Chneiweiss Hervé , Dubart-Kupperschmitt Anne , Duclos-Vallée Jean-Charles , Clément Bruno , Flacher Vincent , Galzi Jean-Luc , Gidrol Xavier , Goureau Olivier , Guasch Géraldine , Haiech Jacques , Lemaitre Christine , Mahé Maxime M. , Martin Sophie , Poulain Laurent , Sebastiani Corinne , Vergnolle Nathalie , Yates Frank
Published: November 2023

Depuis une dizaine d’années, des progrès considérables ont été réalisés concernant les conditions qui permettent à des cellules de s’auto-organiser dans l’espace comme elles le font lors des phases précoces du développement embryonnaire ou dans certains tissus adultes. On nomme ainsi « organoïdes » des structures en trois dimensions complexes, organisées et intégrant plusieurs types cellulaires, qui peuvent reproduire in vitro certaines fonctions d’un organe. Toutefois, ces organoïdes ne peuvent actuellement reproduire à l’identique une architecture anatomique et fonctionnelle complète. Bien qu’utilisé pour des raisons de simplification pour la communication, en particulier dans la presse généraliste, il est donc abusif d’utiliser le terme « mini-organes » pour décrire ces structures.
Observation clinique : Hépatite par surcharge en cuivre chez un chien
Authors: Kaufmann Hugo , Da Riz Fiona , Benchekroun Ghita
Published: November 2023

Un chien mâle entier croisé type Berger, âgé de 9 ans, est présenté en consultation pour dysorexie et amaigrissement évoluant depuis 6 mois. À l’examen clinique, un ictère franc et une cachexie sont mis en évidence. Les premiers examens complémentaires révèlent une hépatite chronique, avec une augmentation de l’activité des enzymes hépatiques, une hyperbilirubinémie et un foie hypoéchogène. Les recherches infectieuses et les cytoponctions de foie et de bile ne sont pas concluantes. Des biopsies hépatiques sous cœlioscopie sont alors réalisées. Leur analyse histologique et le dosage de cuivre conduisent au diagnostic d’hépatite cuprique. Un traitement à base de chélateur de cuivre (D-pénicillamine) et une alimentation pauvre en cuivre sont initiés, mais des complications liées à l’insuffisance hépatique amènent au décès de l’animal 4 mois après la présentation initiale. Ce cas clinique illustre que les surcharges hépatiques en cuivre ne surviennent pas que chez les races prédisposées (Bedlington terrier et Labrador en particulier). Des apports alimentaires excessifs en cuivre sont suspectés comme étant à l’origine de l’augmentation des cas d’hépatopathie cuprique ces dernières décennies. Le diagnostic, difficile, repose avant tout sur l’analyse histologique du parenchyme hépatique et le dosage du cuivre intra-hépatique.
Regulationsstörung beim Säugling – aktuelle Ergebnisse einer Behandlungsoption mit einem anthroposophischen Komplexarzneimittel
Authors: Gruber Kim , Stintzing Florian C. , Turek Claudia , Zilkowski Ilona , Mörbt Nora , Vögele Peter
Published: November 2023

In einer multizentrischen prospektiven nicht interventionellen Studie haben wir die Anwendung eines Komplexarzneimittels mit Extrakten aus Kümmel, Kamille, Tollkirsche und Tabak bei Säuglingen mit Bauchbeschwerden, Unruhezuständen sowie Schlafstörungen untersucht. Ziel war es, Daten zur Anwendung, Sicherheit, Verträglichkeit, zum Therapieverlauf und zur Akzeptanz der Behandlung zu erfassen. Hebammen, Kinderärzt*innen und Eltern dokumentierten die Behandlung von Säuglingen unter einem Jahr, die aufgrund der oben genannten Symptome das Arzneimittel Carum carvi comp. Säuglingszäpfchen (WALA Heilmittel GmbH, Bad Boll, Deutschland) erhielten. Vom ersten bis zum letzten Beobachtungstag gab es eine signifikante Reduktion der Beschwerden und der Schreidauer, während sich die Schlafdauer signifikant erhöhte. Therapieverlauf und Verträglichkeit wurden als „gut“ oder „sehr gut“ bewertet. Die Anwendung war sicher, führte zu einer Verringerung der Beschwerden und wurde mehrheitlich positiv bewertet.
Parenteral Fosfomycin in Gastrointestinal Surgery: A Systematic
Review
Authors: Fonnes Siv , Fonnes Masja Klindt , Holzknecht Barbara Juliane , Rosenberg Jacob
Published: November 2023

Background To investigate if perioperative parenteral administration of
fosfomycin given before or during gastrointestinal surgery could protect against
postoperative infectious complications and characterise the administration of
fosfomycin and its harms.

Methods This systematic review included original studies on
gastrointestinal surgery where parental administration of fosfomycin was given
before or during surgery to≥5 patients. We searched three databases on
March 24 2023 and registered the protocol before data extraction
(CRD42020201268). Risk of bias was assessed with Cochrane Handbook risk of bias
assessment tool or the Newcastle-Ottawa Scale. A narrative description was
undertaken. For infectious complications, results from emergency and elective
surgery were presented separately.

Results We included 15 unique studies, reporting on 1,029 patients that
received fosfomycin before or during gastrointestinal surgery. Almost half of
the studies were conducted in the 1980s to early 1990s, and typically a dose of
4 g fosfomycin was given before surgery co-administered with metronidazole and
often repeated postoperatively. The risk of bias across studies was moderate to
high. The rates of infectious complications were low after fosfomycin; the
surgical site infection rate was 0–1% in emergency surgery and
0–10% in elective surgery. If reported, harms were few and mild
and typically related to the gastrointestinal system.

Conclusion There were few postoperative infectious complications after
perioperative parenteral administration of one or more doses of 4 g fosfomycin
supplemented with metronidazole in various gastrointestinal procedures.
Fosfomycin was associated with few and mild harms.
Prevention of peri-interventional hypothermia during endoscopic retrograde cholangiopancreatography using a forced-air heating system
Authors: Stahl Klaus , Schuette Eloise , Schirmer Paul , Fuge Jan , Weber Anna-Lena , Heidrich Benjamin , Schneider Andrea , Pape Thorben , Krauss Terence , Wedemeyer Heiner , Lenzen Henrike
Published: November 2023

Background and study aims Perioperative hypothermia is associated
with significant complications and can be prevented with forced-air heating systems (FAHS).
Whether hypothermia occurs during prolonged endoscopic sedation is unclear and prevention
measures are not addressed in endoscopic sedation guidelines. We hypothesized that hypothermia
also occurs in a significant proportion of patients undergoing endoscopic interventions
associated with longer sedation times such as endoscopic retrograde cholangiopancreaticography
(ERCP), and that FAHS may prevent it.

Patients and methods In this observational study, each patient
received two consecutive ERCPs, the first ERCP following current standard of care without FAHS
(SOC group) and a consecutive ERCP with FAHS (FAHS group). The primary endpoint was maximum
body temperature difference during sedation.

Results Twenty-four patients were included. Median (interquartile
range) maximum body temperature difference was −0.9°C (−1.2; −0.4) in the SOC and −0.1°C
(−0.2; 0) in the FAHS group (P < 0.001). Median body temperature
was lower in the SOC compared with the FAHS group after 20, 30, 40, and 50 minutes of
sedation. A reduction in body temperature of > 1°C (P <
0.001) and a reduction below 36°C (P = 0.01) occurred more often in
the SOC than in the FAHS group. FAHS was independently associated with reduced risk of
hypothermia (P = 0.006). More patients experienced freezing in the
SOC group (P = 0.004). Hemodynmaic and respiratory stability were
comparable in both groups.

Conclusions Hypothermia occurred in the majority of patients
undergoing prolonged endoscopic sedation without active temperature control. FAHS was
associated with higher temperature stability during sedation and better patient
comfort.
Urgent ERCP performed with single-use duodenoscope (SUD) in patients with moderate-to-severe cholangitis: Single-center prospective study
Authors: Masciangelo Graziella , Cecinato Paolo , Bacchilega Igor , Masetti Michele , Ferrari Rodolfo , Zagari Rocco Maurizio , Napoleon Bertrand , Sassatelli Romano , Fusaroli Pietro , Lisotti Andrea
Published: November 2023

Background and study aims To assess the outcomes of urgent endoscopic retrograde cholangiopancreatography (ERCP) performed with a single-use duodenoscope (SUD) in patients with moderate-to-severe cholangitis.

Patients and methods Between 2021 and 2022 consecutive patients with moderate-to-severe cholangitis were prospectively enrolled to undergo urgent ERCP with SUD. Technical success was defined as the completion of the planned procedure with SUD. Multivariate analysis was used to identify factors related to incidence of adverse events (AEs) and mortality.

Results Thirty-five consecutive patients (15 female, age 81.4±6.7 years) were enrolled. Twelve (34.3%) had severe cholangitis; 26 (74.3%) had an American Society of Anesthesiologists (ASA) score ≥3. Twenty-eight patients (80.0%) had a naïve papilla. Biliary sphincterotomy and complete stone clearance were performed in 29 (82.9%) and 30 patients (85.7%), respectively; in three cases (8.6%), concomitant endoscopic ultrasound-gallbladder drainage was performed. Technical and clinical success rates were 100%. Thirty-day and 3-month mortality were 2.9% and 14.3%, respectively. One patient had mild post-ERCP pancreatitis and two had delayed bleeding. No patient or procedural variables were related to AEs. ASA score 4 and leucopenia were related to 3-month mortality; on multivariate analysis, leukopenia was the only variable independently related to 3-month mortality (odds ratio 12.8; 95% confidence interval 1.03–157.2; P=0.03).

Conclusions The results of this “proof of concept” study suggest that SUD use could be considered safe and effective for urgent ERCP for acute cholangitis. This approach abolishes duodenoscope contamination from infected patients without impairing clinical outcomes.
Patient Selection for Follicular Unit Extraction versus Linear Strip Donor Harvesting
Authors: Konior Raymond J.
Published: November 2023

Follicular unit grafts can be harvested using two methods: strip follicular unit transplantation and follicular unit excision. Each method can generate outstanding results, but both are uniquely different with respect to the advantages and disadvantages they offer. Devising a sound surgical plan is instrumental to assure that a patient's short-term and long-term goals can be met, but creating the best plan possible for the graft harvest process is not straightforward. This paper will review the various advantages and disadvantages of each graft harvest method, along with their short-term and long-term ramifications, so as to provide insight into the process by which a sound surgical plan can be developed for any patient seeking surgical hair restoration.
Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases
Authors: Péč Martin Jozef , Jurica Jakub , Péčová Monika , Benko Jakub , Sokol Juraj , Bolek Tomáš , Samec Marek , Hurtová Tatiana , Galajda Peter , Samoš Matej , Mokáň Marián
Published: November 2023

Platelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune diseases. This review aims to highlight the role of platelets in the pathogenic mechanisms of the most frequent chronic autoimmune inflammatory diseases to identify gaps in current knowledge and to provide potential new targets for medical interventions.
A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
Authors: Berger Dana Senderoff , Galyean Anna , Nguyen Kelvin , Alshak Najeeb , Blumenthal Elizabeth
Published: November 2023

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy.

We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis.

Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect.
Evaluations of training programs to improve capacity in K*: a systematic scoping review of methods applied and outcomes assessed
Authors: Shewchuk Samantha , Wallace James , Seibold Mia
Published: November 2023

This paper examines how frequently K* training programs have been evaluated, synthesizes information on the methods and outcome indicators used, and identifies potential future approaches for evaluation. We conducted a systematic scoping review of publications evaluating K* training programs, including formal and informal training programs targeted toward knowledge brokers, researchers, policymakers, practitioners, and community members. Using broad inclusion criteria, eight electronic databases and Google Scholar were systematically searched using Boolean queries. After independent screening, scientometric and content analysis was conducted to map the literature and provide in-depth insights related to the methodological characteristics, outcomes assessed, and future evaluation approaches proposed by the authors of the included studies. The Kirkpatrick four-level training evaluation model was used to categorize training outcomes. Of the 824 unique resources identified, 47 were eligible for inclusion in the analysis. The number of published articles increased after 2014, with most conducted in the United States and Canada. Many training evaluations were designed to capture process and outcome variables. We found that surveys and interviews of trainees were the most used data collection techniques. Downstream organizational impacts that occurred because of the training were evaluated less frequently. Authors of the included studies cited limitations such as the use of simple evaluative designs, small cohorts/sample sizes, lack of long-term follow-up, and an absence of curriculum evaluation activities. This study found that many evaluations of K* training programs were weak, even though the number of training programs (and the evaluations thereof) have increased steadily since 2014. We found a limited number of studies on K* training outside of the field of health and few studies that assessed the long-term impacts of training. More evidence from well-designed K* training evaluations are needed and we encourage future evaluators and program staff to carefully consider their evaluation design and outcomes to pursue.