bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Aplikasi Area untuk Meningkatkan Pemahaman Matematis Siswa pada Materi Keliling Bangun Datar Kelas V
Authors: Lestari Wulan Sri , Irawati Riana , Maulana Maulana
Published: January 2025

This investigation was prompted by pupils' inability to comprehend the diameter of two-dimensional figures. Students often experience boredom in studying due to the teacher's exclusive reliance on lecture methods, which adversely impacts their comprehension of the circumference of planar shapes. This research aims to create an Android-based application named AREA to enhance fifth-grade students' comprehension of flat figures at SD Negeri Setiajaya 01 and to evaluate its practicality. The employed research methodology is Research and Development (R&D) utilizing the ADDIE model for the development phase. The research instruments employed included validation sheets for material experts, media experts, pretest-posttest questionnaires, and response surveys for teachers and students. Data analysis methodologies for expert and educator validation are assessed via a Likert scale; thereafter, pretest and posttest evaluations employ N-Gain formula analysis, while media appropriateness is gauged by questionnaires directed at instructors and students. The research findings indicate that the Android-based AREA media is highly valid for usage, as evidenced by validation results from material and media specialists, which yielded an average percentage of 98% in the highly viable category. The media's suitability can be assessed through the teacher questionnaire results, which yielded a score of 92%, and the student response questionnaire, which indicated a score of 99%. According to these findings, AREA media can be classified as highly appropriate for educational purposes. Apart from that, the N-gain persent or N-gain percentage results were also abtained at 66,93% so that based on these result it can be said that AREA media is “effective enough” to be used in the learning process.
Online Marriage from the Perspective of Islamic Law and Positive Law at the Junrejo District Religious Affairs Office
Authors: Haj Habil Syahril , Hamidah Tutik
Published: January 2025

This research aims to analyze the validity of online marriage contracts according to Islamic law by examining the perspectives of various schools of fiqh and Indonesian positive law. The research method used is qualitative with a descriptive approach. Data collection was carried out through interviews and observations. To enhance data validity, the researcher used source triangulation. The findings show that scholars differ in their opinions regarding the validity of online marriage. The Shafi'i, Maliki, and Hanbali schools reject it due to the emphasis on physical presence, while the Hanafi school permits it as long as the offer and acceptance are conducted simultaneously, even if from different locations. In Indonesia, online marriage is not yet regulated by law, but the Indonesian Ulema Council (MUI) allows it if a representative is used. These findings reflect that, although technology allows for online marriage contracts, caution in adhering to the essential conditions of the contract remains a primary concern.
FORMULATION AND EVALUATION OF ANTIDIABETIC TABLET FROM CNIDOSCOLUS ACONITIFOLIUS LEAF EXTRACT
Authors: Dev Jesna , Narayanan Neena , T Anagha
Published: January 2025

Diabetes is a growing health concern worldwide, leading researchers to explore natural alternatives for
managing blood sugar levels. Cnidoscolus aconitifolius, commonly known as Chaya Mansa, is a plant
known for its potential antidiabetic properties. The purpose of this study was to create, develop and assess antidiabetic tablets
from the leaf extract of Chaya Mansa. The study utilized the direct compression method to form the tablets and focused on
optimizing their properties, particularly their physical characteristics and their effectiveness in managing Diabetes compared
to the standard drug Acarbose. Various physicochemical properties were assessed. Preformulation studies were done to
evaluate pre-compression parameters of powder blends. Compatibility of the drug with excipients was deterimined by FT-IR
spectral analysis. Three different tablet formulations, labeled F1, F2, F3 were created using the direct compression method and
then evaluated based on several physical properties & organoleptic characteristics. Additionally, the tablet formulations were
tested for their in vitro anti diabetic activity using Alpha amylase enzyme inhibition method. However, among the three
formulations, F3 emerged as the most promising candidate, demonstrating effective physical properties and superior in vitro
anti diabetic activity compared to other formulations.
RELATIVE EFFECTIVENESS OF CONSTRUCTIVIST APPROACH AND TRADITIONAL APPROACH ON LEARNING OUTCOMES OF SCIENCE AT SCHOOL LEVEL
Authors: Chadar Keerti , Kumar Saurabh
Published: January 2025

Constructivism promotes an epistemology that focuses on the process of knowing rather than the
accumulation of knowledge itself. It is a theory that explains how humans learn and make meaning of the
world. Constructivist education claims to not only full practical educational needs but also push the limits of teaching,
learning, and knowledge to enhance education at various levels. The constructivist approach serves as a method for achieving
educational goals effectively. This approach allows for the development of various strategies and tactics aimed at specic
learning outcomes. Additionally, it can foster educational innovation by exploring new methods, resources, and tools to address
educational challenges. In this study, a sample of 120 students, both boys and girls, from a government school in Sagar city,
were selected for analysis. This research demonstrated that the intervention implemented with the experimental group
successfully enhanced their science performance. Intervention given through constructivist approach shows better results in
achievement test as compared to traditional approach.
A CLINICAL ODYSSEY INTO OCULAR TB- SERPIGENOUS LIKE CHOROIDITIS, UNMASKED !!
Authors: M Sameeksha. , N Inchara.
Published: January 2025

Another rare cause of posterior uveitis that falls within the category of white dot syndromes is serpiginous
choroiditis. Although it is caused by an inammatory process, diseases like tuberculosis (TB) may be
correlated with it (serpiginous-like choroiditis). Southeast Asian nations are more likely than Western nations to report cases of
tubercular serpiginous-like choroiditis. We report a case of a middle-aged Indian female with bilateral grey-yellowish subretinal
choroidal inltrates with active scalloped edges having a positive TB-QuantiFERON Gold test who responded excellently to the
treatment of systemic steroids (given initially to control the acute inammation) while on anti-tubercular (anti-TB) therapy. The
lesions nally completely healed on the anti-TB therapy and treatment was terminated.
UTILITY OF ETHYLENE DIAMINE TETRAACETIC ACID DECALCIFICATION IN BETTERMENT OF QUALITY OF BONE MARROW TREPHINE BIOPSY
Authors: B Waghmare Jayshree , Balsubramanian Meenakshi , B Shetty Jyothi
Published: January 2025

Bone marrow trephine biopsy(BMTB) is a valuable source of material in diagnosis of neoplastic and non
neoplastic hematological conditions.The biopsy after xation has to be decalcied.Conventionally the
tissue is processed without decalcication or decalcied using nitric acid is used or at some centres.Either of this results in many
artifects like serrations and folds in the tissue and does not preserve the morphology of the cells rendering in making the
diagnosis very difcult.Obtaining BMTB is a painful procedure and cannot be attempted multiple times.By using Ethlyene
diamine tetra acetic acid(EDTA) for decalcication the morphology is well preserved and also the proteins making it possible to
improve the sensitivity ,specicity and reproducibility of various tests like immunohistochemistry(IHC) and molecular
studies.This contributes greatly to the diagnosis ,prognosis ,treatment of patient and provides guidelines to the clinicians in
making decisions.The aim of this study was to determine whether EDTA decalcication yielded superior quality slides
compared to nondecalcied tissue.
CORRELATION OF CYTOLOGY AND CELL BLOCK PREPARATION OF ENDOMETRIAL ASPIRATE WITH ENDOMETRIAL BIOPSY
Authors: Sharma Aarti , Khare Anjali , Chauhan Kavita , Gupta Smriti , Sharma Sangeeta , Chaturvedi Trishla
Published: January 2025

Endometrial cancer is a prevalent malignancy among women, with early detection crucial for better
outcomes. This study evaluates the diagnostic utility of endometrial aspiration cytology (EAC) and cell
block (CB) techniques compared with biopsy, the standard diagnostic method. Conducted at a tertiary hospital, this crosssectional study involved 121 patients with endometrial abnormalities. Specimens from EAC and CB were analyzed and
correlated with biopsy ndings to assess sensitivity, specicity, positive and negative predictive value. Results showed a high
concordance between CB and biopsy diagnoses. EAC and CB were particularly effective for assessing benign and hormonerelated pathologies, proving to be practical, minimally invasive alternatives to biopsy. Findings suggest that CB preparation,
with its preserved cellular architecture, enhances diagnostic yield, potentially reducing the need for more invasive procedures.
Future research may explore molecular markers in CB preparations for further diagnostic renement.
AN ORGANIZATIONAL ANALYSIS OF STEEL INDUSTRY OPERATIONS: CHALLENGES AND STRATEGIC RESPONSES
Authors: D Derlin , S Jeyavisahan
Published: January 2025

This study, entitled “An Organizational Analysis of Steel Industry Operations: Challenges and Strategic
Responses,” explores the dynamics of individual and group behavior within an organizational setting, as
well as the nature of organizations themselves. Organizational studies aim to understand and model the factors that come into
play whenever people interact in an organization. This type of analysis is essential for MBA graduates as it helps them connect
theory with practice. The organizational study was conducted at Valli Steel Industries Pvt. Ltd., a company specializing in the
manufacturing of high-quality stainless steel “ASI 304 GRADE” kitchen sinks, located in Nagercoil. The study is based on
information gathered from the departmental heads of the organization. A SWOT analysis was performed to evaluate the
company's strengths, weaknesses, opportunities, and threats. Key strengths identied include the company's experienced
workforce, the efcient and healthy relationship between employers and employees, and exibility in production volumes and
design. Weaknesses include insufcient funds for further expansion, a lack of effective marketing strategies, technological
obsolescence, inefcient management, and marketing deciencies. Opportunities include a growing demand for its products,
the judicious purchase of raw materials, and the outsourcing of large units. The threats identied are environmental concerns,
technological advancements, and the entry of new competitors into the market. The study highlights the strong relationship
between employees and top management.
A PROSPECTIVE STUDY TO EVALUTE ROLE OF NEGATIVE PRESSURE WOUND THERAPY-NPWT (VAC THERAPY) IN WOUND MANAGEMENT
Authors: Sonkar Raghunandan , Singh Arul , Jain Avinash , Agrawal Dhruv
Published: January 2025

Introduction: Wound management remains one of the most discussed topic in orthopaedics, No one
technique has been proved to be Novel and Accepted to all yet. Negative pressure wound therapy, or
Vaccum Assisted Closure (VAC) dressing has emerged as a pivotal tool in the management of wounds in orthopedic trauma,
offering signicant results. To Evaluate role of NPWT ( VAC THERAPY) in Orthopaedics Trauma and Woun Aim: d Management
Materials And Methods- A total no of 47 patients were included in the study conducted at Index Medical College between Dec
22 to July 24, Patients who had Traumatic, Infective and those having Post operative wound dihense were included in the study.
Routine Preoperative Investigations CBC, Blood Sugar levels, Culture Senstivity BT, CT were done. Th Result: is study of
Vacuum-Assisted Closure (VAC) dressing in orthopaedics demonstrates signicant benets in infection control, wound size
reduction, and favorable nal outcomes. VAC therapy promotes wound healing by providing a controlled, moist environment
and enhancing tissue perfusion. This method has proven effective in reducing bacterial colonization, which plays a critical role
in infection control. Additionally, the continuous negative pressure aids in wound contraction, contributing to a marked
decrease in wound size over time Our Study Concluded that, Vac Therapy Provides Sterile Environment, Conclusion: which
enhances Wound healing by Decreasing the infective load, granulation formation and wound contracture, Additional denitive
management of wounds through skin grafts or secondary closure is also seen.
MIB INDEX AS INDEPENDENT PROGNOSTIC FACTOR IN CONTEXT OF CLINICAL FEATURES IN CARCINOMA BREAST PATIENTS.
Authors: Sadanand M Karandikar , Himanshi Joon , Shailesh Puntambekar
Published: January 2025

Introduction: Breast cancer is the commonest malignancy in females and despite recent advancements
in treatment it still is the leading cause of death. The importance of various clinical and pathological
factors like age, tumor size, hormone receptor status, lymph node status and grade of tumor are already established and play
key role in deciding the management of disease. Markers like Mib Index are under evaluation and its role is yet to be
established as independent prognostic factor. Our study is an attempt to understand and evaluate its role in the management
of breast cancer patients and its relation with other clinical features especially in this era of molecular advancement where tests
Oncotype Dx, Mammaprint & likes are not affordable to all. Materials and Methods: Mib index and other clinic-pathological
markers were retrospectively assessed in 174 breast cancer patients diagnosed and treated between 2018 and 2021.
Association and correlation with other established prognostic markers was studied. Statistical analysis was done and p value
< 0.05 was taken as signicant. Results: Mib Index was low in 37.7% and high in 62.3% patients. Next we analyzed the
association between MIB index and other prognostic parameters, and we found a statistical signicant association with age,
grade of the tumor, histology, hormone receptor status, HER 2 neu status and lymph node positivity while there was no
signicant association with tumor size. Conclusion: Mib Index may be considered as a valuable parameters to plan out further
treatment strategies in breast cancer patients as *poor woman's Oncotype Dx" in our scenario.
A COMPARATIVE STUDY OF BONE MARROW ASPIRATION AND BONE MARROW BIOPSY IN HAEMATOLOGICAL DISEASES IN A TERTIARY CARE CENTER OF CENTRAL INDIA-A RETROSPECTIVE STUDY
Authors: Mishra Surabhi , Rai Sunita
Published: January 2025

Introduction: Bone marrow examination is a diagnostic tool which is very important to evaluate various
hematological disorders including neoplastic and non-neoplastic both. The two most important
techniques are bone marrow aspiration (BMA) and bone marrow trephine biopsy (BMB) used for the diagnosis; are
complementary to each other. Bone marrow aspiration (BMA) provides information about the number and cytological features;
whereas bone marrow trephine biopsies (BMB) provide excellent appreciation of spatial relationships between cells and to
overall bone marrow structure. To compare the diagnostic values of bone marrow aspiration and Bone Aim and Objectives:
Marrow biopsy. A total of 217 cases with both bone marrow aspiration and biopsy were included in thi Material and Methods: s
study. All the aspirate smears were routinely stained by Leishman Giemsa while the trephine biopsy sections were stained by
routine Hematoxylin and Eosin (H&E) stain. All the smears and sections were reviewed and the ndings on BMA & BMB were
compared and the nal correlation done. Chronic Myeloid Leukemia(C.M.L.) was the most common diagnos Result: is followed
by Acute Leukemia. The diagnostic accuracy of C.M.L.was 100% as compare to Acute Leukemia(96.6%).The diagnosis
accuracy of BMA in our study was 84.09%. Bone marrow aspiration and Bone Marrow biopsy are complemen Conclusion: tary
to each other and the superiority of one method over the other depended on the underlying disorder. BMA provides better study
of the cell, whereas biopsy provides details about the pattern of cellular distribution, level of brosis etc. hence when performed
together it gives better diagnostic accuracy and corellaion. Furthermore, application of ancillary techniques such as ow
cytometery and IHC proved to be an additional advantage in further typing of various diseases.
COMPARATIVE STUDY OF BIOCHEMICAL ALTERATION IN COVID-19 AND NON COVID 19 PATIENTS: ASSOCIATION WITH LIVER FUNCTION TESTS ABNORMALITIES.
Authors: Dwivedi Jyoti
Published: January 2025

Abnormal liver functions are frequently reported in patients with COVID-19. Liver enzyme abnormalities
are common in patients with coronavirus disease 2019 (COVID-19). The aim of the study was the
evaluation of liver function test parameters in patients with COVID-19 and non Covid -19 patients and analysis of the
relationships between serum level of total Protein, albumin, aspartate amino transferase, alanine amino transferase, alkaline
phophatase, total bilirubin, C-Reactive protein and ferritin with COVID-19 and non Covid -19 patients. Signicantly deecreased
levels of serum total Protein, albumin, and increased level of aspartate amino transferase, alanine amino transferase, alkaline
phophatase, total bilirubin, C-Reactive protein and ferritin with COVID-19 compare to non Covid -19 patients.
EVALUATION OF DESARDA'S TECHNIQUE IN MANAGEMENT OF INGUINAL HERNIA REPAIR
Authors: Dilip Mankar Hrushikesh , M. Shinde Rajendra , Chauhan Nikhil , Magu Nishant , Mishra Aditya , Chidrawar Sarth
Published: January 2025

The preferred treatment for a common problem like an inguinal hernia is mesh-based repairs. Desarda's approach to
inguinal hernia repair is a unique technique that stands out for its practicality, low rate of recurrence, and affordability.
Present study was conducted with the aim of to evaluate Desarda's technique in management of inguinal hernia repair.
Our findings suggest that the Desarda technique is a good substitute for the methods used now.
EVALUATION OF SERUM ISCHEMIA MODIFIED ALBUMIN LEVEL IN PATIENTS WITH MYOCARDIAL INFARCTION.
Authors: Kujur Vineeta , Khodiar P. K. , Rath D. P , Kujur Anurag
Published: January 2025

Background: Myocardial infarction requires early diagnosis for patient benefit. One of the cause of myocardial
infarction can be ischemia. In ischemia, there is reduction in cobalt binding affinity of albumin, due to the free radical
damage of N-terminal site,which is cobalt binding site of albumin molecule.This modified albumin is called as ischemia
modified albumin (IMA).Method:50 patients of diagnosed myocardial infarction (MI) and 50 healthy control group were
evaluated for serum ischemia modified albumin level using albumin cobalt binding method by colorimetry. Result:
Total of 100 subjects were evaluated. 50 cases (15 female& 35 male) of myocardial infarction and 50 healthy controls
(19female & 31 male) were studied. In our study mean level of serum IMA was found to be 0.46±0.26 ABSU in control
group & 0.91±0.24 ABSU in cases of MI.Serum level of ischemia modified albumin level is significantly raised in cases of
MI as compared to healthy control group (p=0.01). Conclusion:Ischemia modified albumin evaluation may be helpful
in identification of myocardial ischemia.
STUDENTS' ACHIEVEMENT AND ATTITUDE TOWARDS ENGLISH WITH REFERENCE TO GENDER, RESIDENCE, AND STREAMS OF STUDY
Authors: Lampa Wangnen , Reena Tok Boa , Boli Geyin
Published: January 2025

The current study examined the attitude of the senior secondary students of Tirap district, Arunachal Pradesh, India
towards English.It explored a differential analysis to find significant differences in the attitude and achievement levels of
these students in relation to variables including gender, residence, and stream of study. 350 senior secondary students
were added to the sample for examination. The data collected were analysed and interpreted with the use of mean,
standard deviation, and t-test and there were two tools applied in the present study such as, (i) The Attitude Towards
English Language Scale (ATELS) developed by Clara Dominique (2016),and (ii) Personal data sheet.The findings of the
study indicated a high attitude level towards English among the senior secondary students in the district. Above and
beyond,the result revealed no significant difference in the attitude of senior secondary students with respect to gender,
residence, and streams of study variables. Besides, no significant difference was observed in the achievement level of
these students in relation to the residence variable as against the variables such as gender and streams of study that
displayed a significant difference for the same.
EVALUATIVE PRACTICE IN SANSKRIT EDUCATION OF ASSAM: A STUDY AT SECONDARY SCHOOL LEVEL
Authors: Das Alaka
Published: January 2025

Sanskrit's significant cultural and educational role in India necessitates modernized teaching methods and effective
assessment techniques. While robust educational goals and infrastructure are important, the true effectiveness of
Sanskrit education depends on teachers and their assessment methods. Often criticized for focusing too much on
content and grammar-translation, Sanskrit teaching can lead to a decline in student interest.This study investigates the
assessment techniques used by Sanskrit teachers in secondary schools in Assam's Nalbari district,involving 100 school
heads and 100 Sanskrit teachers.The findings aim to develop a more effective approach to teaching Sanskrit,enhancing
student performance and interest in the language.
Exploring the Impact of Organizational Well-Being on Intention to Leave the Nursing Profession: a Scoping Review
Authors: Basso Rossella Roberta , Della Bella Valerio , Fiorini Jacopo , Sili Alessandro
Published: January 2025

Introduction. In several countries, the desire among nurses to leave their profession is a significant concern. Recent studies highlight a relationship between the nursing working context and the intention to leave the profession, indicating that suboptimal working conditions significantly influence the willingness to remain a nurse. This literature review aims to define the relationship between nurses' organizational well-being and intention to leave the profession, analyzing which organizational well-being variables influence this decision.
Materials and methods. A scoping review was conducted on PubMed, Scopus, CINAHL, and Cochrane. The Joanna Briggs Institute’s (JBI) methodology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines have been followed. Critical appraisal and data extraction were conducted using the JBI tools. Data were extracted and analyzed according to narrative synthesis.
Results. The search yielded 3,224 references. Following the review process, twelve articles were included in the review. Four main categories of variables were identified: job satisfaction, working conditions, physical-psychosocial health, and economic and professional recognition. Balanced workloads and organizational demands, adequate resources, and positive relationships between colleagues and patients characterized a supportive work environment where nurses lived in a condition of well-being and their intention to leave the profession decreased. In contrast, high workloads, overtime, insufficient resources, and lack of managerial support increased the intention to leave the profession.
Discussion. The relationship between nurses' well-being and their intention to leave the profession has been identified. Healthcare organizations should improve the individual and organizational well-being of nurses as strategies to promote their retention. Understanding turnover drivers enabled healthcare managers to address critical issues that promoted retention by fostering sustainable work environments. Future multicenter studies should implement interventions to promote organizational well-being and evaluate the nurses' turnover intentions.
Care also for nurses in their healthcare organizations
Authors: Stievano Alessandro , Gennaro Susan
Published: January 2025

Not available.
Exploring the Potential of Virtual Reality (VR) in Developing Students' Thinking Skills: A Narrative Review of the Last Five Years
Authors: Faresta Rangga Alif , Nicholas Teo Zhao Ser Bryan , Chi Yixuan , Sinambela Indah Astri Natalia , Mopoliu Abdul Ziqron
Published: January 2025

Addressing the persistent issue of inadequate critical thinking skills among students, this study examines the potential of Virtual Reality (VR) to transform educational practices. Traditional teaching methods often prioritize rote memorization, limiting opportunities for higher-order cognitive processes such as analysis, synthesis, and evaluation. This narrative review synthesizes findings from the past five years, focusing on VR’s ability to enhance thinking skills. Employing a systematic literature search via Scopus, 24 reviewed studies were analyzed, highlighting VR’s immersive and interactive capabilities in fostering critical thinking, problem-solving, and engagement. Results indicate that VR surpasses traditional methods by offering experiential learning scenarios, promoting collaboration, and addressing diverse educational needs. Applications in STEM and professional education demonstrate improved cognitive outcomes, including spatial reasoning, decision-making, and retention of abstract concepts. However, challenges such as high costs, infrastructural constraints, and teacher training gaps hinder widespread adoption. Ethical considerations around data privacy and inclusivity further underscore the need for strategic implementation. This study concludes that VR holds transformative potential in education, provided challenges are addressed through targeted investments, interdisciplinary innovations, and inclusive practices. Future research should emphasize long-term studies and integrate emerging technologies like AI and AR to maximize VR’s impact on cognitive skill development.
Applications of Biosynthesized Nanoparticles for Environmental Protection and Sustainability
Authors: Tariq Muhammad Abuzar , Shahzadi Iqra , Arshad Robia , Siddiqi Muhammad Arslan , Naseer Adeeba , Bibi Zainab , Rasheed Ehsin , Amir Muhammad Ali , Zeeshan Muhammad
Published: January 2025

As an environmentally friendly substitute for conventional nanoparticle manufacturing techniques, biosynthesized nanoparticles have become a ground-breaking instrument in sustainability and environmental protection. Because these nanoparticles are made from biological materials like plants, microbes, and enzymes, they don't require dangerous chemicals and use less energy. They are adaptable for tackling important environmental issues because of their distinct physicochemical characteristics, which include large surface area, adjustable size, and form. Applications include air purification via the catalytic breakdown of volatile organic molecules and wastewater treatment, where they efficiently eliminate heavy metals, organic contaminants, and pathogens. Additionally, biosynthesized nanoparticles are essential for soil remediation because they accelerate the breakdown of contaminants and increase soil fertility. Their antibacterial qualities prevent environmental diseases from spreading, improving public health. The most exciting recent developments have investigated their possibilities in sustainable agriculture, where they show great potential in encouraging plant growth and controlling pests, offering hope for a more sustainable future. In addition to addressing the difficulties and constraints in their large-scale production and use, this review explores the synthesis mechanisms, environmental applications, and aspects of biosynthesized nanoparticles, highlighting their role in promoting a sustainable and environmentally friendly future.
Review on Natural Treatment of Dysemohrrea
Authors: Abhilasha D. , Nikitha E. , Supriya I.
Published: January 2025

Dysmenorrhea is known as the sever menstrual pains that are caused due to release of higher (or) lower levels of prostaglandisis. The release of prostaglandis is from sexual hormones. These Dysmenorrhea is treated through different traditional medicinal system like (Ayurveda, unnani, sidda etc). These systems are reducing pain trough different herbals. The herbals are obtain from different parts of the plants like (roots, stems, fruits. Flowering tips etc..). The herbal drugs that not only reduce the pain of the menstrual cramps but also causes many beneficial affects to the health to the females. The herbal drugs that are naturally obtained from the soil so theses are not having any sides effects in there menstrual time. These herbals having analgesic, and blocking of release of prostaglandins and decreasing the prostaglandins. These drugs reduce the pain from roots of cause. The herbals a play main and important role in reducing the menstrual cramps and menstrual mood. These drugs are helps to reset the mood of the females and theses natural drugs will cure the menstrual cramps for roots of cause.
Comparison between Analyte Results Obtained by two Very Common HPLC Systems Used in Haemoglobinopathies: Evaluation Done at Metropolis a Referral Laboratory in Kolkata, India
Authors: Saha Dr Subhasish , Rakshit Dr Dipanjan
Published: January 2025

Thalassemia is a heterogenous group of disorders caused by inherited mutations that decrease the synthesis of adult hemoglobin, HbA, (α2β2). The two α chains in HbA are encoded by an identical pair of α globin genes on chromosome 16 while the β chain are encoded by single β globin gene on chromosome 11. Β thalassemia is caused by deficient synthesis of β chain, whereas α thalassemia is caused by deficient synthesis of α chain. Alkaline hemoglobin electrophoresis is a common first step in confirmation of hemoglobinopathies. Electrophoresis is based on the separation of hemoglobin molecules in an electric field primarily because of differences in total molecular charge. HPLC and capillary electrophoresis are gaining in popularity because these methods are more automated, the instruments are more user friendly, and they can be used to confirm hemoglobin variants observed with electrophoresis. The two most common instrumentations used for identification of Hb electrophoresis are Bio-Rad D10 and Tosoh G11. This study is used to find out the comparison of Haemoglobin electrophoresis between Bio-Rad and Tosoh.
Juvenile Myelomonocytic Leukemia: A Case Report
Authors: Errim Ahl Cheikh , Bouanani Fatima , Hicham Yahyaoui , Mohammed Chakour
Published: January 2025

Juvenile myelomonocytic leukemia (JMML) is a rare pathology affecting the hematopoietic stem cell. Its pathophysiology is linked to deregulation of the RAS signal transduction pathway. It is a rare, myelodysplastic-myeloproliferative disease typically presenting in early childhood. This disorder is difficult to distinguish from other myeloproliferative syndromes such as chronic myeloid leukemia (CML) because of the similarities in their clinical and bone marrow findings. However, because of its unique biological characteristics such as absolute monocytosis with dysplasia, absence of Philadelphia chromosome or BCR-ABL fusion protein, hypergammaglobulinemia, and raised fetal hemoglobin level, this disorder does not satisfy the criteria for inclusion in the CML or chronic myelomonocytic leukemia (CMML) group, as seen in adult patients. We report the case of a male infant aged 15 months who was hospitalized for prolonged fever associated with tumor syndrome. This case has been reported in line with The 2016 iteration of the World Health Organization classification of myeloid neoplasms. The interest of this observation is to describe a rare case of JMML.
Double Breast Neoplasia: RH+, HER2- Metastatic Left Breast Cancer and Triple Negative Metastatic Right Breast Cancer: Case Report
Authors: Chahbounia Imane , Lamine Saida , Slimani Khaoula Alaoui , Sahel Omar Ait , Tanz Rachid , Errihani Hassan , Ichou Mohammed
Published: January 2025

Breast cancer is the most common cancer in women, and the proportion of metastatic cancer is not negligible; either metastasis of a cancer that was initially localized, or metastatic disease from the outset. The case of double breast neoplasia is not exceptional; but when faced with two breast cancers, both metastatic, and with different molecular profiles, several questions arise. Case report: We report the case of a diabetic patient with localized RH+, HER2- left breast cancer treated with surgery and adjuvant chemotherapy in 2003, which became metastatic to the lung in 2022, and for which the patient received hormone therapy + anti CDK4/6. In the same month as the pulmonary lesions were discovered, a right breast cancer was diagnosed, biopsied as triple-negative; this metastasized to the brain in 2024. Conclusion: the problem in this case concerns the rarity of occurrence of two metastatic breast cancers for the same patient, the complexity of therapeutic management, and makes us think about intra-tumoral heterogeneity in breast cancer.
Uncommon Association of Primary Biliary Cholangitis and Ulcerative Colitis in a Male Patient, Cirrhosis as a Presenting Feature: A Case Report
Authors: R Semlali , A Handa , F Chakor , O Nacir , F Lairani , A Ait Errami , S Oubaha , Z Samlani , K Krati
Published: January 2025

Primary biliary cholangitis (PBC) is a chronic autoimmune cholangitis characterized by progressive destruction of the small intrahepatic bile ducts, leading to cholestasis and, potentially, liver cirrhosis. While its clinical and biological manifestations are well-documented, its association with inflammatory bowel disease (IBD) remains rare. Inflammatory bowel disease, particularly ulcerative colitis (UC), is frequently linked to hepatobiliary disorders, most notably primary sclerosing cholangitis (PSC). However, the co-occurrence of PBC and UC is highly uncommon and poorly understood. We report a rare case of a male patient in whom PBC and UC coexisted, with cirrhosis being the initial presentation. This case highlights the need for heightened clinical suspicion of atypical hepatobiliary associations in IBD patients and underscores the importance of early recognition and management.
Selective Twin Deformity in Di-Chorionic Twins: A Case Study
Authors: Ngalande Ngawa Edith , Alaoui Fatima Zohra Fdili , Jayi Sofia , Sanoh Abraham Alexis , Chaara Hikmat , Melhouf Moulay Abdelilah
Published: January 2025

Neural tube defects (NTD) are a group of congenital malformations of the brain and spine, the etiology of which is still debated. Although presumed to be the consequence of interactions between genetic and environmental factors, so far, it is not known which genes are involved in the pathogenesis of these malformations. Dichorionic twin pregnancy discordant for fetal hydrocephalus (HC) with spina bifida is a serious condition that threatens the normal co-twin’s life by causing foetal growth restriction, preterm labor and sudden death of one or both of the fetuses. This is a case report on twin pregnancy with fetal hydrocephalus and spina bifida associated with congenital hip dysplasia and a club foot, recognized in the 32th week of gestation. Course of pregnancy and management during labour are described. The peculiarity of our observation is the importance in establishing the significance of environmental factors as well as a genetic basis in NTD. Some occupational and other exposures, including maternal use of antiepileptic drugs (AEDs), are associated with increased risk for NTDs. Among women who have had an NTD-affected pregnancy, recurrence risk is markedly higher than the risk for a first NTD-affected pregnancy in the general population. There is strong evidence, overall, for a protective effect of adequate folate consumption. In some high-risk groups, however, such as women taking AEDs, folate supplementation has not been proven to reduce NTD risk.
Paraphayngeal Primary Tuberculosis Manifesting as Submucosal Oropharyngeal Tumor: A Case Presentation and Litterature Review
Authors: Marie Nizigiyimana Jean , Elias Niyomwungere , Ouahidi Youness , Ouattassi Naouar , Afellah Mohamed , Ridal Mohammed , Najib Benmnsour , Zouheir Zaki , Abdellatif Oudidi , Amine Mohammed Nouredine EL Alami El
Published: January 2025

Although tuberculosis is a major cause of morbidity and mortality, primary tuberculosis of the oropharynx is rare, accounting for only 0.05% to 5% of all tuberculosis cases. The upper respiratory tract is resistant to tuberculosis, mainly due to the presence of saliva which, in addition to its cleansing action, has an inhibitory effect on tubercle bacilli. The symptoms of oropharyngeal tuberculosis may resemble a malignant tumour, particularly in elderly patients. Confirmation of primary parapharyngeal tuberculosis requires histological examination and a search for negative koch's bacilli in negative bronchial secretions. Treatment is antituberculosis.
Prediksi Prestasi Akademik Siswa Jurusan PPLG dengan Metode Algoritma Decision Tree (Studi Kasus: SMK Negeri 1 Depok)
Authors: Siddiq Farhan Maulana
Published: January 2025

SMK (Sekolah Menengah Kejuruan) adalah institusi pendidikan menengah di Indonesia yang fokus pada pemberian keterampilan praktis dan kejuruan. SMK menyediakan pendidikan yang lebih terarah pada persiapan siswa untuk langsung memasuki dunia kerja setelah lulus. Prestasi akademik siswa di Sekolah Menengah Kejuruan (SMK) memiliki dampak yang sangat berpengaruh terhadap perkembangan karier dan masa depan siswa. Oleh karena itu, prediksi prestasi akademik siswa menjadi penting dalam rangka mengidentifikasi faktor-faktor yang dapat memengaruhi kesuksesan siswa tersebut.penelitian ini bertujuan untuk memprediksi prestasi akademik siswa berdasarkan beberapa faktor seperti nilai, penghasilan orang tua, jenis kelamin, dan transportasi ke sekolah menggunakan data mining dengan algoritma Decision Tree dengan menggunakan tools Orange3-3.37.0-Python3.10.11-x86_64. Subjek penelitian ini terdiri dari 73 siswa kelas X jurusan PPLG di SMK Negeri 1 Depok. Data untuk penelitian ini dikumpulkan dari pihak sekolah SMK Negeri 1 Depok. Berdasarkan pengujian yang telah dilakukan dari algoritma Decision Tree menunjukkan akurasi sebesar 98,6%, nilai AUC (Area Under the Curve) sebesar 87,5%, Recall sebesar 98,6%, Precision sebesar 98,6%, dan F1-Score sebesar 98,5%. Dengan demikian, algoritma decision tree ini dapat memprediksi prestasi akademik siswa dengan tingkat ketepatan yang tinggi.
Blaski i cienie życia renesansowego poety Jerzego Sabinusa
Authors: Chrobot Agata
Published: January 2025

Jerzy Sabinus (prawdziwe nazwisko: Georg Schuler; ur. 23 IV 1508r. w Brandenburgu – zm. 2 XII 1560r. we Frankfurcie nad Odrą) był dyplomatą, poetą, cenionym znawcą literatury greckiej i rzymskiej, jej tłumaczem, edytorem i komentatorem oraz pierwszym rektorem Uniwersytetu Albertyna w Królewcu.
Poezja Sabinusa pełna jest opisów różnych punktów zwrotnych w życiu poety, najważniejsze to: studia na Uniwersytecie w Wittenberdze, relacje przyjacielskie ze swoim nauczycielem - Filipem Melanchtonem, ślub z Anną Melanchton, ważna dla każdego humanisty podróż do Italii, objęcie stanowiska rektora na nowo założonym Uniwersytecie w Królewcu i związana z tym przeprowadzka, śmierć żony, wyjazd z Królewca i ponowny powrót oraz odbyte misje dyplomatyczne.  
Sabinus kształcił się na uniwersytecie w Wittenberdze, gdzie poznał Filipa Melanchtona, a w roku 1536 ożenił się z jego córką Anną (Elegie III 1-7). Anna Melanchton była kobietą nieprzeciętną, bardzo dobrze wykształconą i niebywale zdolną. Poeta w wielu utworach mocno akcentuje pochodzenie Anny, ożenek z córką jednego z największych uczonych z pewnością przysporzył mu sławy, do chrztu niósł Annę sam Marcin Luter (El. VI 7).
Kolejnym punktem zwrotnym dla poety była podróż do Italii, którą odbył w latach 1533-1534 (Hodoeporicon itineris Italici). Sabinus wyprawił się w tę długą i niebezpieczną podróż w celu edukacji oraz aby zawrzeć nowe znajomości, dzięki którym został włączony do grona elity humanistycznej ówczesnej Europy. Podczas tej peregrynacji poznał Aleandra, Lazzarra Bonamica, Joannesa Baptistę Egnatiusa i weneckiego kardynała Piotra Bemba, z którym przyjaźnił się do śmierci przyjaciela.
Kolejną zmianą w życiu poety była przeprowadzka do Królewca i objęcie stanowiska pierwszego rektora Uniwersytetu Albertyna w Królewcu  w 1544 roku (El. V 6-10, VI 3,5, 6).
W Królewcu 27 lutego 1547 roku w wieku 25 lat zmarła żona poety Anna z domu Melanchton. Po czterech latach sprawowania urzędu rektora w roku 1547 zrezygnował z tej funkcji i opuścił Królewiec. W latach 1552 i 1553 powrócił tam ponownie na stanowisko rektora.
            W artykule przedstawiam zarówno te dobre, jak i te złe momenty w życiu poety, które rozrzucił po kartach wielu swoich utworów.
Ksiądz Stanisław Kulanowski (1892-1957) – wychowawca i opiekun młodzieży, dyrektor Bursy im. księdza Feliksa Dymnickiego w Rzeszowie
Authors: Barnaś-Baran Ewa
Published: January 2025

Ksiądz Stanisław Kulanowski był nauczycielem, wychowawcą i opiekunem młodzieży w Rzeszowie. Kształcił i wychowywał uczniów najstarszego Gimnazjum w mieście w latach 1930-1950, a także organizował opiekę zdolnym, ale ubogim uczniom w Bursie gimnazjalnej. Dodać należy, że jego działalność pedagogiczna i społeczna obejmowała również inne szkoły, a także stowarzyszenia i przynosiła wymierne rezultaty w mieście w latach 1924-1950. Prowadził katechizację zgodnie z przepisami prawa kościelnego, był moderatorem Sodalicji Mariańskiej, aktywnie uczestniczył w zebraniach i pracach stowarzyszeń katolicko-społecznych. Troszczył się o kościół gimnazjalny, był dyrektorem Bursy gimnazjalnej. Zaangażowanie w wychowanie moralne młodzieży w duchu katolickim, czynny udział w reaktywowaniu działalności organizacji katolickich po 1945 r. w Rzeszowie, przyczyniły się do represji ze strony władz państwowych w Polsce Ludowej. Wskutek realizowanej przez ówczesne państwo polityki likwidacji stowarzyszeń świeckich i katolickich po 1947 r. ksiądz Kulanowski został oskarżony i skazany na karę więzienia. Bursa, której był dyrektorem została upaństwowiona.
Odkrycie siarki jako ważny punkt zwrotny w biografii
Authors: Kutyła Małgorzata
Published: January 2025

Punkt zwrotny, jakkolwiek różnie definiowany, wiąże się ze zdarzeniami, które uświadamiają jednostce zakres jego oddziaływania. Rozpoznanie znaczenia punktu zwrotnego wymusza nowe postawy, nowe wartości i nowe biograficzne komponowanie. Celem artykułu jest poznanie i opisanie jak odkrycie złóż siarki w okolicach Tarnobrzega stało się ważnym punktem zwrotnym w biografii Narratora. W życiu Pana Michała pojawiły się wydarzenia, które modyfikowały jego dotychczasową egzystencję. Konfrontacja z poważnymi trudnościami miała charakter progresywny, „otwierający” na nowe transformacje. W rezultacie Narrator doświadczył różnych wydarzeń, które w sposób trwały zmieniały koleje jego losu oraz definiowanie siebie.
Hagiografia i biografie zakonne polskich karmelitanek bosych w XVII wieku
Authors: Nowicka-Struska Anna
Published: January 2025

Przedmiotem zainteresowań badawczych w niniejszym artykule jest środowisko sióstr polskich XVII w., karmelitanek bosych i ich twórczość, ze szczególnym uwzględnieniem pism hagiograficznych i biograficznych zakonnych. Te gatunki literackie wpisują się w szerzej rozumianą barokową twórczość kobiecą, która nie została dotychczas w pełni zbadana. Tematyka pism monastycznych, zwłaszcza zakonów żeńskich, jest niezwykle interesująca. Dzieje się tak nie tylko ze względu na jakość wciąż odkrywanych tekstów, ale także ze względu na niezwykle hermetyczne środowisko, w jakim teksty te powstawały oraz zamknięty, niezwykle ograniczony obieg dzieł rękopiśmiennych. Na potrzeby niniejszego opracowania w pierwszej części przedstawiono proces tworzenia i wykorzystania hagiografii w klasztorze karmelitów, natomiast w drugiej części wykorzystano dwa teksty hagiograficzne dla egzemplifikacji postawionych w nim tez.
THE MODERATING EFFECT OF FIRM SIZE ON THE RELATIONSHIP BETWEEN FINANCIAL VARIABLES AND EARNING RESPONSE COEFFICIENT
Authors: Hendro Paulus  , Deden Tarmidi
Published: January 2025

This study aims to examine the effect of dividend payout ratio, leverage, and profitability on earning response coefficient with firm size variables as moderators. The sample in this study uses a purposive sampling technique with a sample number of 80 data. The data processing in this study uses EVIEWS 13 to test the hypothesis that has been established. The results showed that the dividend payout ratio had an effect on the earning response coefficient, while leverage and profitability showed that there was no effect on the earning response coefficient, and the firm size was able to moderate the dividend payout ratio to the earning response coefficient, and the firm size was unable to moderate the leverage and profitability to the earning response coefficient. Overall, the variables studied in this study were able to explain 71.7% of the earning response coefficient.
KEYWORDS: Earning Response Coefficient, Dividend Payout Ratio, Leverage, Profitability, Firm Size
Percepción del servicio, satisfacción, autoeficacia y bienestar psicológico en la motivación para el cambio y adicciones de drogodependientes en rehabilitación
Authors: Gaxiola Villa Eunice , Gaxiola Romero José Concepción , Pineda Domínguez Antonio
Published: January 2025

El objetivo de la presente investigación fue evaluar la relación entre la percepción del servicio del centro de rehabilitación, la satisfacción del usuario, el bienestar psicológico y la autoeficacia en la motivación (para el cambio conductual y dejar las drogas) en hombres adultos internos en centros de rehabilitación de drogas del Noroeste de México. Se realizó un estudio transversal con 118 adultos (media = 25 años y D.E = 9.43). Se aplicaron preguntas sociodemográficas y las escalas: funcionamiento del centro y percepción del clima, satisfacción de los usuarios, motivación para dejar las drogas, motivación para el cambio, autoeficacia general, y bienestar psicológico. Se encontraron relaciones significativas y positivas entre las variables del estudio, exceptuando la satisfacción de los usuarios con el bienestar psicológico. Se discute la importancia de promover la calidad del servicio en los centros de rehabilitación de drogas y el fomento del bienestar psicológico en los internos.
Intervención grupal para estrés en jugadores de disc golf con integración TCC/TBCS
Authors: Arratia Velarde Mario Andres , González Ramírez Mónica Teresa
Published: January 2025

El presente estudio evalúa la eficacia de cuatro sesiones de un tratamiento integrativo de la terapia cognitivo conductual junto a la terapia centrada en soluciones en el manejo del estrés en jugadores de disc golf de alto rendimiento. Se presenta evidencia bibliográfica que fundamenta la posibilidad de un tratamiento integrado efectivo para la reducción de estrés en atletas. Con una muestra de 7 participantes se realizó una prueba de rangos de Wilcoxon con medidas pretest y postest de cuestionarios estandarizados que miden características psicológicas relacionadas con el rendimiento deportivo, pensamiento centrado en soluciones, pensamientos negativos automáticos y estrés percibido. Los resultados mostraron un efecto significativo en reducción de pensamientos negativos automáticos (W = 21, p = 0.017), aumento de pensamiento centrado en soluciones (W = 1.5, p = 0.037) y características psicológicas relacionadas al deporte (W = 0.0, p = 0.016). No se observó un efecto significativo en la reducción de estrés percibido. Se concluye un beneficio empírico en el manejo del estrés de los atletas.