bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Assessment Based on D-S Evidence Theory of Equipment
Authors: Sun Tanghui , Liu Bailin
Published: January 2021

Prognosis and Health Management (PHM) is the important technical means to achieve condition based maintenance(CBM), and Health assessment is the important part of the PHM system. PHM is widely used in aerospace area, But it lacks application in ground field, In order to improve the accuracy of self-propelled gun system health assessment, taking a certain self-propelled gun system as the object, in this paper, takes self-propelled gun as an example, divide it’s health status into 5 levels, for equipment that fails the test, it can be directly determined to be in a fault state; for equipment that has passed the test, and come up with a model of health assessment that based on D-S evidence theory, first, Select the health indicators which can comprehensively represent the status of propelled artillery, and use the normalized quantization method to Process the data. Then, employ the D-S evidence theory to make the integrated decision on the membership of each health parameter after treatment, finally, determine the ultimately health status of self-propelled artillery, the rationality of the method is verified by experiments.
Discussion on Decimal Network Based on IPV9
Authors: Shun Hu , Xu Dongmei , Gao Lin
Published: January 2021

This paper introduces the core technology of decimal network digital domain name and IPV9 protocol family, and analyzes the technical characteristics of decimal network. Three kinds of common network transition techniques are listed, and various problems of decimal network application are discussed.
Data Visualization Analysis of COVID-19 Epidemic Situation
Authors: Yang Tao
Published: January 2021

2019 Novel Coronavirus (COVID-19) has brought immeasurable losses and huge impact to the world. For human health, many Centres for Disease Control(CDC) in various countries around the world are actively collecting data and doing a good job in virus prevention and control. The real-time release of the epidemic situation, with analysis and prediction, is a very effective method to combat the epidemic. By studying the situation of epidemic data, based on Jupyter Notebook, this paper gives the visual analysis process of COVID-19 epidemic data, and carries out specific analysis and implementation. And then it estimates the coronavirus converges roughly using sigmoid fitting. Although the sigmoid fitting tend to underestimate the curve, its actual value tend to be more than sigmoid curve estimation. The proposed data visualization analysis method could effectively display the status of the COVID-19 epidemic situation, hoping to help control and reduce the impact of the COVID-19 epidemic.
Sixfold fermion near the Fermi level in cubic PtBi2
Authors: Thirupathaiah Setti , Kushnirenk Y. S. , Koepernik Klaus , Piening B. R. , Buechner Bernd , Aswartham S. , van den Brink Jeroen , Borisenko Sergey , Fulga Ion Cosma
Published: January 2021

We show that the cubic compound PbBi2 is a topological semimetal hosting a sixfold band touching point in close proximity to the Fermi level. Using angle-resolved photoemission spectroscopy, we map the band structure of the system, which is in good agreement with results from density functional theory. Further, by employing a low energy effective Hamiltonian valid close to the crossing point, we study the effect of a magnetic field on the sixfold fermion. The latter splits into a total of twenty Weyl cones for a Zeeman field oriented in the diagonal, (111) direction. Our results mark cubic PbBi2 as an ideal candidate to study the transport properties of gapless topological systems beyond Dirac and Weyl semimetals.
The clinical significance of computer capillaroscopy for differential diagnosis of the respiratory tract diseases in children
Authors: Mizernitsky Yu. L. , Melnikova I. M. , Udaltsova E. V.
Published: January 2021

Computerized capillaroscopy of the nail bed is a non-invasive and most accessible method for studying microcirculation parameters in children; it is effectively used in a wide variety of pediatric pathologies. However, there are only few studies in this promising direction in children with acute and chronic bronchopulmonary diseases.

Objective. To evaluate the morpho-functional features of capillary blood flow in children with the respiratory system diseases of infectious and allergic genesis and to evaluate their clinical significance.

Materials and method. 238 children aged from 2 to 17 years with acute and chronic respiratory diseases were examined in the in-patient and outpatient hospitals. Along with traditional clinical methods all patients underwent computerized capillaroscopy of the nail bed to assess the morphological and functional state of the microvasculature.

Results. Children with allergic diseases of the respiratory tract are characterized not only by pronounced structural changes in the capillaries in the form of weak differentiation at the level of capillaries of the third tier, but also by functional disorders of the capillary bed. They include a change in the parameters of all parts of the capillary and a marked increase in the length of the perivascular zone, interconnected with the activity level of chronic allergic inflammation. These changes were most pronounced in patients with bronchial asthma. The patients with infectious diseases of the respiratory system are characterized by a change in microcirculation parameters predominantly in the venous section of the capillaries, they are more pronounced in patients with lower respiratory tract diseases rather than with upper respiratory tract diseases.

Conclusion. Structural and morpho-functional changes in microcirculation revealed by computerized nail capillaroscopy of the nail bed can be used as additional differential diagnostic criteria in the algorithms for the diagnosis of allergic diseases of the respiratory tract, which will contribute to the early detection of this pathology and timely therapy.
Coping Strategies and Accentuations of Personality Traits in First-Year Students with Different Levels of Subjective Well-Being
Authors: Yashchenko E. F. , Lazorak O. V.
Published: January 2021

The research objective was to determine the features, interrelations, and differences in subjective well-being, coping-strategies, and accentuations of personality traits. The experiment featured first-year students with different levels of subjective well-being that majored in technical sciences at the South Ural State University (National Research University) in Chelyabinsk (Russia). The research involved the subjective well-being scale developed by Perrudet-Badoux, Mendelsohn, and Chiche in M. V. Sokolova’s adaptation, R. Lazarus’s coping-test, and G. Schmieschek and K. Leonhard’s questionnaire. The experiment included 43 male students (mean age – 17,8), who were divided into three groups according to the level of subjective well-being. The first-year students with high and medium levels of subjective well-being had a wide range of coping strategies. The students with a low level of subjective well-being had an insufficient personal and psychoemotional resource to cope with adversities. The authors also defined priority links between accentuations, coping strategy, and subjective wellbeing. The experiment confirmed the hypothesis that first-year students with different levels of subjective well-being would have different indicators of coping strategies and accentuations of personality traits, as well as different structure of research scale connections. The results can help to create programs for the development of coping strategies in first-year students.
Propositional Frame-Based Analysis of the Semantics of Proverbs of the Russian and Chinese Languages (Based on Frame Father – Son)
Authors: Li Hong Guo , Abdullayeva F. E.
Published: January 2021

Propositional frame-based modeling is one of the most effective methods of cognitive linguistics. This method considers the interaction between the semantic and cognitive aspects of units of two typologically different languages, e.g. Russian and Chinese, in order to study the way language structures and reflects human knowledge and experience. Propositional structures are the same for all languages, but they are implemented differently in every language. The authors used the propositional frame-based analysis to identify universal and specific aspects in the semantics of proverbs based on frame father – son, which is an important fragment of the Russian and Chinese linguistic world view. The cognitive potential of paroemiological units is enormous: proverbs reflect historical, cultural, linguistic, and extralinguistic cognitive experience. Cognitivists define experience as one’s knowledge about stereotypical situations, stored in one’s mind as frames. A frame is a collection of vertex ("top") and terminal ("low") components. Vertex components are formed by concepts that are valid in relation to the stereotypical situation of the frame. As a result, they are clearly structured and constant. The "low level" is not constant, and its terminals are variable. The semantics of the proverbs in question were represented by frames. The meanings of their components formed a common and complex situation. Knowledge about this situation made it possible to perceive the meaning of each proverb in a holistic way. The proverbs could be interpreted as units that activate a certain cognitive context about the content and structure of the concepts father and son in Russian and Chinese.
Modal Verbs in the Modern Chinese Language
Authors: Sadovnikova O. N. , Sharavieva I. V.
Published: January 2021

The article presents a new view on Chinese modal verbs as a part of speech. Based on the typology of the Chinese language, the authors analyzed modal verbs according to their functional-syntactic, formal-morphological, and semantic features in order of importance. The article discusses the position of modal operators in the sentence and other characteristics. For instance, Chinese modal verbs have no impact on the object and cannot independently form sentences or combine with grammemes. Therefore, the authors believe that Chinese modal verbs (modal operators) belong to the lexical-grammatical group of adverbs as a special category of intentional adverbs. Their intentionality reflects the outward focus of linguistic consciousness, based on the internal reference point of the speaker. The group includes such meanings as "wish", "obligation", "opportunity", "permission", and "will". The research owes its theoretical significance to the fact that it contributes to a better understanding of the essence and nature of modal operators and modality meanings, identifying them as a separate group of adverbs. The obtained results are applicable in the field of theoretical grammar of the Chinese language and can be used in researches related to further analysis of parts of speech problem in the Chinese language.
Author's Creativity in Modern Fiction (Based on Russian "Besoboi" Comic Series)
Authors: Engel E. A.
Published: January 2021

Linguistic creativity is currently attracting a lot of scientific attention. Such scientists as V. P. Korovushkin, J. Falojou, O. K. Iriskhanova, A. V. Galkina, and V. Z. Demyankov define linguistic creativity as a person's ability to create and use original, non-standard linguistic means and techniques, which is mainly used in personal discourse, i.e. in fiction narrative, everyday speech, or phatic discourse. The present research featured authentic linguistic creativity in the modern comic book series called "Besoboi". Authentic linguistic creativity means the author's ability to use and generate new original, non-standard linguistic means, and techniques, or to commit deliberate linguistic violations at various language levels in their own text. The research objective was to identify and describe linguistic means, techniques, and violations that make up the linguistic creativity in the text of the Russian comic book series "Besoboi". The author analyzed works by Russian and foreign scientists in the field of linguistic creativity, fiction, and language violations. The study was based on the methods of description, interpretation, comparison, and generalization. The author's linguistic creativity manifested itself in the comic book as an ability to generate innovative words and use such stylistic devices as parody, oxymoron, alliteration, lithotes, hyperbole, pun, etc. In addition, the text contained a lot of original idioms, epithets, and similes. However, there is a tendency to classify many of these expressive means and techniques as linguistic violations, grammatical or stylistic. The author's creativity also manifested itself in the fictional world, unusual plots, new types of heroes, e.g. a superhero with mystical abilities, demons, etc. All linguistic transformations on the level of phonetics, spelling, derivation, vocabulary, and grammar are deliberate, and so are the communicative deviations, as the author generates and uses them deliberately to achieve a certain effect.
Classification of Customs Documents of the Siberian Chancellery in the Second Part of "Review of Rolls and Books…" by N. N. Ogloblin
Authors: Sokolovskii I. R.
Published: January 2021

The accuracy of any historical research depends on independent verification of the related data and the completeness of available sources. According to nineteenth-century French historians, "Documents make History", which means that all available written sources are equally important for solving a particular task. In this aspect, classification of historical sources can be of great help. Like any classification, it groups its objects according to the presence or absence of an essential feature. Perhaps, the most famous methodological school was founded in Novosibirsk by S. S. Rozova, who dealt with issues of scientific classification. In the modern domestic tradition of the historical methodology, classification of historical sources is one of the most important research steps. It allows historians to give a genuine scientific character to their studies. However, classification of sources is not a mechanical action. As a creative process, it leads to variability. The present article introduces a comparative analysis of two classifications of historical sources on the history of Yakutia, which belonged to N. N. Ogloblin and V. F. Ivanov. N. N. Ogloblin created a detailed classification of sources, which covers the main groups of customs documentation. However, his second volume was found lacking.
Globalization of the Internal Enemy Image in the Soviet Visual Propaganda during the Early Cold War (1946–1953)
Authors: Fedosov E. A. , Genina E. S.
Published: January 2021

The present research featured a generalized historical experience in the formation and development of a particular segment of Soviet propaganda during the early Cold War (1946–1953). The authors focused on the visual propaganda as a component of ideological impact. The study involved 240 propaganda posters and over 2,000 magazine and newspaper caricatures published in 1946–1953. The reconstruction of events was part of content analysis of the ideological and propaganda campaigns that the USSR waged as its confrontation with the West began to escalate. The concept of Soviet patriotism was the key idea in the state ideology. The analysis made it possible to specify some features of the symbolic language of visual propaganda. It also revealed the relationship between international and domestic political scenarios through certain varieties of the enemy image. The authors assessed the effectiveness of propaganda in terms of social and political attitude expressed by Soviet citizens. The authors revealed a complex of various means, which included official publications, posters, and cartoons and was used to influence the mass consciousness and form certain ideological attitudes.
Specific Features of the Generation Z Family Values System
Authors: Grigoryeva E. V. , Khakimova N. R.
Published: January 2021

The research featured family values of the so-called Generation Z. The survey involved an authentic survey, S. S. Nosov’s Family Values Questionnaire, and the Morphological Test of Life Values developed by V. F. Sopov and L. V. Karpushina. A comparative analysis proved that Generation Z and Generation Y have both similar and different views on family values. The sphere of marriage and parenting had more differences, while the sphere of kinship showed more similarities. Representatives of Generation Z appeared to accept the idea of cohabitation; they also tended to get married relatively late in life. The gap between the optimal age of marriage for men and women proved to be quite narrow, while the age of first childbirth for women approximated that of men. In general, Generation Z shifted to an egalitarian family type. Unlike Generation Y, members of Generation Z valued spiritual satisfaction and underestimated achievements. In the hierarchy of family life values, they focused on spiritual satisfaction, self-development, individuality, and active social contacts. The research results can be used in health and family life education programs.
Estimating COVID-19 Early Pandemic Severity in Indian Context
Authors: Mandal Manisha , Mandal Shyamapada
Published: January 2021

Objective: To explore the early pandemic severity of COVID-19 in India in terms of various case fatality rate (CFR) estimates. Methods: Various COVID-19 fatalities: confirmed CFR (cCFR), asymptomatic CFR (aCFR), symptomatic CFR (sCFR), and hospitalized CFR (HFR) were estimated along with relative susceptibility of developing symptoms (RSODS) and relative susceptibility of developing infection (RSODI) determination for Psym (probability of developing symptoms) 0.50, 0.75, and 0.95 each for all age groups. Results: The cCFR, aCFR, sCFR, and HFR estimates were 2.32% (2.05-2.59), 0.14% (0.12-0.16), 0.32% (0.27-0.36), 1.86% (1.64-2.07) respectively. The RSODS and RSODI of COVID-19 were ~33 times higher among people aged <45 years. The RSODS estimates were 1.97 (0.47-3.47), 0.62 (0.15-1.09), 0.29 (0.07-0.52), 0.06 (0.02-0.10) respectively, for patients <45 years, 45-60, 60-75, >75 years. Similar trend, for RSODI were found, with relatively higher value, compared to RSODS, which decreased with the increase of age. The 14-day lag estimate of CFR were 18.07 (15.67- 20.47), and outcome (deaths plus recoveries)-based estimate of CFR were 16.57 (14.65-18.49). The growth rate, serial interval, reproduction number and average time from onset of COVID-19 infection to death were 6.12% (5.30%-6.99%), 11.4 days (9.91-12.85), 1.03 (1.01-1.05), and 11.85 days (10.55-13.15), respectively. The average daily recovery was 19.45% (14.75- 24.15) and average cumulative recovery was 12.68% (10.70- 14.66) among COVID-19 patients. Conclusion: Detecting all possible cases throughout the course of the COVID-19 pandemic real CFR could be estimated to evaluate the effectiveness of healthcare systems and new treatments
Digital Rectal Examination of Prostrate : Does Examiner's Experience influence the Results ?
Authors: Moorthy Dr. H. Krishna , S Pillai Biju , Bhaskar Mehta Sony
Published: January 2021

There is lack of uniformity in grading the size or assessing the consistency of prostate gland with Digital Rectal Examination (DRE) when done by different clinicians during evaluation of prostate pathology. This study was to compare the results of DRE findings in prostate pathology performed by Urologists at three different levels of clinical practice in the same set of patients and assess the accuracy of the findings with respect to their clinical experience. Materials and Methods: 200 patients with clinical features of prostatomegaly having no documented Urinary Tract Infection were subjected to DRE separately by one Resident in his Final year of training, Junior Consultant (5 years post degree) and Senior Consultant with more than 10 years clinical experience. Their findings were correlated with USG Abdomen estimated volume. Patients with DRE detected hard area in the prostate underwent Trans-rectal tru-cut biopsy of the hard area in the prostate and the biopsy reports were again correlated with the clinical findings. Results: DRE grades assessed by Final year Resident correlated with USG Abdomen estimated volume in 63%, while the same for Junior Consultant was 69% and that for Senior Consultant was 71%. The percentage correlation was better with smaller clinical size of the prostate when the overall DRE assessment of the prostate volume by the three sets of observers was compared to USG Abdomen prostate volume. There was also error in diagnosing abnormal texture of the prostate by Final year Resident in a significant number of patients. Conclusions: There were significant variations in DRE findings of prostate among clinicians, with the accuracy improving with increase in clinician’s experience. DRE findings should always be supplemented with other investigations before a final conclusion regarding the prostate pathology is made.
Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators
Authors: Rauscher Stefanie , Greil Richard , Geisberger Roland
Published: January 2021

Cancer drug resistance is a major problem for cancer therapy. While many drugs can be
effective in first-line treatments, cancer cells can become resistant due to genetic (mutations and
chromosomal aberrations) but also epigenetic changes. Hence, many research studies addressed epigenetic
drugs in circumventing resistance to conventional therapeutics in different tumor entities
and in increasing the efficiency of immune checkpoint therapies. Furthermore, repositioning of already
approved drugs in combination with epigenetic modifiers could potentiate their efficacy and
thus could be an attractive strategy for cancer treatment. Summarizing, we recapitulate current data
on epigenetic drugs and their targets in modulating sensitivity towards conventional and immune
therapies, providing evidence that altering expression profiles by epigenetic modifiers holds great
potential to improve the clinical outcome of cancer patients.
Part 1: The Wider Considerations in Translating Heart Failure Guidelines
Authors: Iyngkaran Pupalan , Wilson Andrew , Wong James , Prior David , Kaye David , Hare David L , Bergin Peter , Jelinem Michael
Published: January 2021

Congestive Heart Failure (CHF) is an emerging epidemic. Within one generation, the
medical community has learned much of CHF syndromes. It has two distinct mechanisms, systolic
and diastolic abnormalities, to account for the common CHF presentation. It is complex as it challenges
the available health care services, resource, and funding models in providing an equitable
service across the health continuum. Despite the improvement in many cardiovascular diseases,
some CHF outcomes like readmissions and costs have increased. The reinvigoration of evidence-
based medicine, the development of health services models of care, and standardisation of
disease processes with taxonomies have also occurred within the same time span. These processes,
however, need to be linked with health policy as presented in white papers. In this paper, we explore
achieving optimal CHF guideline-recommended outcomes as the science approaches realworld
translation.
Pre-clinical Impact of the Synergistic Mechanism of Daptomycin and Ceftaroline on Patients with Methicillin-resistant Staphylococcus aureus Bacteremia Infections
Authors: Eliazar Jennyflore , Johnson Tevin , Chbib Christiane
Published: January 2021

Background:

Our study aims at assessing the pre-clinical impact of the synergistic
mechanism of Daptomycin (DAP) and Ceftaroline (CFT) on patients with Methicillin-Resistant Staphylococcus
aureus Bacteremia infections (MRSAB).

Methods:

A systematic overview was conducted by searching PubMed, Oxford academic, and
Cochrane library up to June 2020. Study selection and data extraction: All English- language clinical
trials, in vitro studies, and case reports related to the synergistic drug therapy for MRSAB.

Results:

In the case of MRSAB infections, we examined two different in vitro studies that showed
effective synergism with DAP and CFT. The Minimum Inhibitory Concentration (MIC) range observed
for each is as follow: DAP 0.125-1 mg/L, CFT 0.38-1 mg/L, DAP + CFT 0.094-0.5 mg/L,
vancomycin (VAN) 0.75-2 mg/L, VAN + CFT 0.25-2 mg/L. DAP + CFT combination displayed
the most efficacy with the lowest MIC. The statistical analysis performed showed that DAP + CFT
obtained significantly lower fractional inhibitory concentration (FIC) values (0.941 ± 0.328) compared
with VAN + CFT. In vitro activities of regimens tested on DAP non-susceptibility and VAN
intermediate after 96 hours showed DAP 8.29 ± 0.03a log10 CFU/mL, VAN 6.82 ± 0.04a log10
Colony Forming Unit (CFU)/mL, CFT 4.63 ± 0.19a log10 CFU/mL, DAP + CFT 1.15 ± 0.20b log10
CFU/mL, VAN + CFT 3.18 ± 0.49a log10 CFU/mL. (a meaning significantly different than DAP
plus CFT, P<equal to 0.001b meaning therapeutic enhancement combination was defined as ≥ 2
log10 CFU/ml reduction over the most active single agent). Based on these results, although DAP
was not susceptible, the Colony Forming Unit (CFU) for DAP and CFT had the best therapeutic results.

Conclusion:

In vitro studies have shown that a combination DAP and CFT is more efficacious
than the combination of VAN and CFT in MRSA bacteremia infections. The synergic effects of
DAP (bactericidal) and CFT (bactericidal) is statistically significant, in recent trials, warranting
promising evidence for its use in complicated bacteremia infection.
Experimental Rodent Models of Vascular Dementia: A Systematic Review
Authors: Tiwari Nidhi , Upadhyay Jyoti , Ansari Mohammad Nazam , Raza Syed Shadab , Ahmad Wasim , Ansari Mohammad Azam
Published: January 2021

Vascular Dementia (VaD) occurs due to cerebrovascular insufficiency, which leads to
decreased blood circulation to the brain, thereby resulting in mental disabilities. The main causes
of Vascular Cognitive Impairment (VCI) are severe hypoperfusion, stroke, hypertension, large vessel
disease (cortical), small Vessel Disease (subcortical VaD), strategic infarct, hemorrhage (microbleed),
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
(CADASIL), and Cerebral Amyloid Angiopathy (CAA), which leads to decreased
cerebrovascular perfusion. Many metabolic disorders such as Diabetes Mellitus (DM), dyslipidemia,
and hyperhomocysteinemia are also related to VaD. The rodent experimental models provide
a better prospective for the investigation of the molecular mechanism of new drugs. A plethora
of experimental models are available that mimic the pathological conditions and lead to VaD.
This review article updates the current knowledge on the basis of VaD, risk factors, pathophysiology,
mechanism, advantages, limitations, and the modification of various available rodent experimental
models.
Computational Insight into the Binding Mechanism of Pyrazinoic Acid to RpsA Protein
Authors: Rehman Ashfaq Ur , Ali Saadat , Rafiq Humaira , Rasheed Salman , Nouroz Faisal , Wadood Abdul
Published: January 2021

Background:

Resistance to the critical first line anti-tubercular drug, Pyrazinamide, is a
significant obstacle to achieving the global end to tuberculosis targets. Approximately 50% of multidrug-
resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are also
Pyrazinamide resistant. Pyrazinamide is a pro-drug that reduces the duration of tuberculosis therapy
time by 9-12 months, while used as an anti-biotic in the 1st- & 2nd-line tuberculosis treatment
regimens. Pyrazinamidase is an enzyme encoded by pncA gene, which is responsible for the amide
hydrolysis of pyrazinamide into active pyrazinoic acid. Pyrazinoic acid can inhibit trans-translation
by binding to ribosomal protein S1 and competing with tmRNA, the natural cofactor of ribosomal
protein S1. Although pncA mutations have been commonly associated with pyrazinamide resistance,
a small number of resistance cases have been associated with mutations in ribosomal protein
S1. Ribosomal protein S1was recently identified as a possible target of pyrazinamide based on
its binding activity to pyrazinoic acid and the capacity to inhibit trans-translation.

Objective:

Despite the critical role played by pyrazinamide, its mechanisms of action are not yet
fully understood. Therefore, this study is an effort to explore the resistance mechanism toward pyrazinamide
drug in Mycobacterium (M.) tuberculosis.

Methods:

An extensive molecular dynamics simulation was performed using the AMBER software
package. We mutated residues of the binding site (i.e., F307A, F310A, and R357A) in the RpsA S1
domain to address the drug-resistant mechanism of RpsA in complex that might be responsible for
pyrazinamide resistance.

:

Moreover, it is challenging to collect the drug mutant to combine the complex of a protein by single-
crystal X-ray diffraction. Thus, the total three structures were prepared by inducing mutations
in the wild-type protein using PyMol.

Results:

The dynamic results revealed that a mutation in the binding pocket produced pyrazinamide
resistance due to the specificity of these residues in binding pockets, which resulted in the
scarcity of hydrophobic and hydrogen bonding interaction with pyrazinoic acid, increasing the CAdistance
between the binding pocket residues as compared to wild type RpsA that led to structural
instability.

Conclusion:

The overall dynamic results will provide useful information behind the drug resistance
mechanism to manage tuberculosis and also helps in better management for future drug resistance.
Overactive Bladder (OAB) Management: An Overview and Scope of Nano Drug Carriers
Authors: Kumar Vikash , Rathor Sandeep
Published: January 2021

All groups/patient's quality of life (QOL) is affected because of overactive bladder (OAB),
which leads to symptoms like urgency/urinary frequency/incontinence and nocturia. Several patients do
not undergo management because of the embarrassment/misconception i.e. it is related to aging only
and even discontinue the treatment due to side effects (repeated incidences). The objective of this review
is to explore all management methods (including active ingredients involved in the treatment) and
envisage the future scope of the different nano methods with minimizing apparent side effects to achieve
a significant effect.
The Effect of Relaxation Technique (Jacobsen and Benson) on Depression, Anxiety, and Stress in Patients with Multiple Sclerosis
Authors: Akbari Ali , Ahmadi Forouzan , Jalili Ebrahim , Khazaei Salman
Published: January 2021

Background:

Multiple sclerosis (MS) is a chronic disease that affects the central nervous
system. Depression, anxiety and stress are the most common psychiatric comorbidities in MS,
which can have adverse consequences. The aim of this study was to determine the effect of relaxation
(Jacobson and Benson) technique on depression, anxiety and stress in MS patients.

Methods:

This clinical trial was conducted since December 2016 to March 2017 in the Multiple
Sclerosis Association and the Neurology Clinic of Farshchian Hospital (Sina) in Hamadan. Sixty
patients with multiple sclerosis were randomly assigned to two experimental (n=30) and control
(n=30) groups. The control group received routine care and experimental group received the relaxation
technique (Jacobson and Benson) in 8 sessions of 60-minute twice a week for 4 weeks in addition
to receiving routine care. The DASS-21 scale was completed by samples before and after the
intervention.

Results:

Results of the study showed that in the intervention group, the scores of depression, anxiety
and stress after using relaxation (Jacobson and Benson) was decreased significantly (P<0.05), while
in the control group no significant decrease was observed (P<0.05).

Conclusion:

The results of this study showed that relaxation (Jacobson and Benson) is effective in
reducing depression, anxiety and stress in patients with multiple sclerosis. Therefore, in addition
to prescribing medication, it is suggested that complementary therapies be performed for these
patients.
Cellular Senescence and COVID-19
Authors: Chowdhury Farhan Rahman , Islam Tofazzal
Published: January 2021

:

Older adults are at a higher risk of developing serious illness and mortality from
COVID-19. Among a multitude of factors, cellular senescence associated with ageing, obesity, cardiovascular
diseases, and diabetes seems to be statistically correlated with severe SARS-CoV-2 infections
and mortality. Surface proteins such as vimentin and CD26 that are differentially expressed
on senescent cells seem important for SARS-CoV-2 attachment and internalization. Potential
therapeutic agents against this novel virus also exhibit senolytic and anti-inflammatory actions,
implicating that their beneficial effects could, in part, be attributed to their senescent cell removal
and the associated inflammatory phenotype neutralizing properties. Elucidating the underlying
molecular mechanisms that connect cellular senescence and severity of SARS-CoV-2 infection
might help direct towards development of effective therapeutics for elderly patients of COVID-19.
Lammerstraat huis Gassée-Maes.
Authors: GT Gt
Published: January 2021

Scheldegevel en interieur.
Borluutstraat (FOTO)
Authors: Collumbien Hugo
Published: January 2021

Borluutstraat. Een betrekkelijk recente foto en toch ook al weer een stukje verleden.
O conceito de pessoa com deficiência e a proposta de um diálogo de cortes: análise do seu significado na Corte Interamericana de direitos humanos e na jurisprudência dos tribunais superiores brasileiros
Authors: Albaine Farias da Costa Flávia
Published: January 2021

RESUMO:A presente pesquisa tem por objetivo analisar os conceitos de pessoa com deficiência no âmbito da jurisprudência da Corte Interamericana de Direitos Humanos e dos Tribunais Superiores Brasileiros, mormente o Supremo Tribunal Federal e Superior Tribunal de Justiça. A partir desse estudo inaugural, os conceitos serão comparados, a fim de determinar se há relação entre eles e, sendo a resposta positiva, se essa relação é de refutação/afastamento conceitual ou de complementação. Para tanto, empregar-se-á a metodologia da hermenêutica constitucional concretizadora. Durante a análise, serão revisitados institutos como o modelo médico e o modelo social de verificação da deficiência, além da teoria das incapacidades, correlacionando-os com as novas leituras conferidas aos direitos fundamentais.
Metodologia cega: uma proposta de metodologia inclusiva
Authors: Cordeiro Zeneide Pereira
Published: January 2021

RESUMO:O objetivo deste artigo é mostrar a trajetória da primeira estudante de Pós-Graduação com deficiência da Universidade Federal do Maranhão – UFMA. Destacando o processo de construção e execução de uma metodologia de pesquisa acessível para pesquisadores com deficiência visual. Enfatiza várias estratégias de resistência que esta estudante criou para combater a ausência de acessibilidade arquitetônica, comunicacional e atitudinal no ambiente acadêmico.
“... Cada instituição fica meio com a cara da população a que serve ...”: entrevista com Cândido Espinheira Filho
Authors: Martins Laércio Melo
Published: January 2021

RESUMO:A presente entrevista tratou sobre a relação entre o Direito e a Psiquiátria, bem como da trajetória da Reforma Psiquiátrica brasileira.Cândido Espinheira Filho é médico. Chefe de equipe de saúde mental da direção geral do INAMPS (1979/1983). Presidente do Conselho Técnico Administrativo da Colônia Juliano Moreira (1981/82). Gerente do Programa de Aperfeiçoamento da Assistência Psiquiátrica do INAMPS/CONASP (1982/83) e Diretor do Hospital Pinel e Coordenador da Campanha Nacional de Saúde Mental na Região Sudeste (1989/90). Membro da Coordenação de Saúde Mental do Estado do Rio de Janeiro (1991/93). Coordenador Municipal de Saúde Mental de Paracambi (1992/93). Presidente do Fundo Municipal de Desenvolvimento Social – Fundo Rio (1995/96). Coordenador de Saúde da Área de Planejamento 4 do Município do Rio de Janeiro (2001). Vice-diretor e Gerente Médico do Instituto Municipal Nise da Silveira (2001/2006).
Respect for non-autonomous persons: dealing with dementia patients
Authors: Segawa Shingo
Published: January 2021

RESUMO:Neste texto, questiono o que significa respeitar pacientes com demência. Além disso, analiso qual abordagem apropriada deve ser empregada ao discutir pacientes com demência, como determinadas pessoas. Examino abordagens diferentes, como a abordagem da autonomia, a abordagem do melhor interesse e a abordagem do conceito de personalidade no sentido forte e fraco. Argumento que a abordagem autônoma que entende os pacientes com demência como capazes de tomar decisões autônomas afirma a validade do princípio de respeitar a autonomia. Por outro lado, a abordagem do melhor interesse se concentra no conforto da experiência atual do paciente para respeitar os pacientes com demência. Assinalo que tanto a abordagem autônoma quanto a de melhor interesse são inadequadas para as questões que endereço neste artigo. Argumento e concluo que a abordagem baseada no conceito de personalidade é apropriada, não no sentido de que a personalidade do paciente é o único fator importante (no sentido forte), mas no sentido de que é um fator importante no respeito ao paciente com demência (no sentido fraco).
Disability Kaleidoscope or the Ability of Invisibleness: method, problems and insights
Authors: Guimarães Machado João Pedro
Published: January 2021

RESUMO:Como a Teoria Política dialoga com a deficiência? Como teorias lidam com a diversidade humana e capacidades várias? Dotado desses enfoques, Disability and Political Theory (2016), editado por Barbara Arneil and Nancy G. Hirschmann, coleciona artigos pertinentes ao estado da arte acadêmico em campos interdisciplinares. Há questões, todavia, não aplacadas: “qual deve ser o método empregado pelos Estudos em Deficiência?”; “há uma identidade de pessoa com deficiência?”; “como deve operar a intersecção com dados científicos e as demais ciências?”; “modelos são necessários?”; “o que deve ser priorizado em um cenário de recursos escassos?”. Essa revisão objetiva engajar dialeticamente cada capítulo, analisando seus méritos e problemas, enquanto esboça soluções
Das capacidades básicas às combinadas como fundamento da dignidade inerente e do direito ao trabalho da pessoa com deficiência
Authors: Souza Iara Antunes de , Oliveira Priscilla Jordanne Silva
Published: January 2021

RESUMO:A Convenção Internacional sobre os Direitos das Pessoas com Deficiência (Carta de Nova Iorque), que tem status constitucional no Brasil, tem como propósito promover, proteger e assegurar o exercício pleno e equitativo dos direitos humanos e liberdades fundamentais das pessoas com deficiência, incluindo o respeito à sua dignidade inerente e o direito ao trabalho, em igualdade de oportunidades com as demais pessoas. Para a interpretação do alcance da inclusão plena e equitativa pretendida às pessoas com deficiência, pretende-se apropriar-se das definições teóricas relacionadas à dignidade, desenvolvidas por Martha C. Nussbaum por meio das capacidades básicas e combinadas. Considerando que o Decreto n. 9.546 de 30 de outubro de 2018 excluiu a previsão de adaptação das provas físicas em concursos públicos para candidatos com deficiência, problematiza-se sua (in)constitucionalidade, notadamente, diante do propósito que anuncia de assegurar o exercício pleno e equitativo das pessoas com deficiência, inclusive, no mercado de trabalho, uma vez pressuposta sua dignidade inerente. Trata-se de pesquisa na vertente teórico-metodológica, realizada por raciocínio dedutivo.
Educação inclusiva: reflexões sobre os aparatos legais que garantem os direitos educacionais de estudantes público-alvo da educação especial
Authors: Lustosa Francisca Geny , Gadelha Ferreira Rebeca
Published: January 2021

RESUMO:Intencionamos apresentar uma compilação dos principais diplomas normativos, notadamente, da Declaração de Salamanca, em 1994, até os dias atuais, que tenham a Educação Inclusiva como escopo primordial do compromisso legislativo com a estruturação da Educação Para Todos. Temos, assim, como fio condutor, a seguinte pergunta de partida: as mudanças legislativas e o caminho histórico percorrido, que têm se expressado em acesso educacional, têm alcançado a universalização dos discursos e das abordagens educacionais? A metodologia utilizada consistiu na coleta de dados em fontes bibliográficas e documentais, ordenados em uma cronologia. Os resultados evidenciam os conteúdos e ganhos, que, ao longo do tempo, foram (re)significando o conceito de deficiência e o papel das pessoas com deficiência na sociedade e na educação.
Acesso à justiça por pessoas surdas: garantias legais e pesquisas acadêmicas
Authors: Hora Mariana Marques da , Azevedo Estenio Ericson Botelho de , Cavalcanti Mirella Correia e Sá
Published: January 2021

RESUMO:Sendo parte da Comunidade Surda, propomo-nos a discutir sobre o acesso à Justiça por Pessoas Surdas, a partir da apresentação de pesquisa bibliográfica e documental realizada entre 2018 e 2019. Procuramos identificar e conhecer os principais instrumentos jurídico-normativos que garantem às Pessoas Surdas, usuárias da língua brasileira de sinais, acesso à Justiça, bem como a literatura acadêmica relacionada com essa temática. Dialogando interdisciplinarmente com Direito, Serviço Social, Estudos da Tradução, Linguística e Estudos Surdos, buscamos a compreensão da situação contemporânea dos Direitos Humanos das Pessoas Surdas sob uma leitura crítica e dialética. Apontamos importantes avanços nas garantias legais, os quais, no entanto, não estão efetivados, havendo ausência de políticas linguísticas e de acessibilidade comunicacional para atender às demandas de Surdos/as no âmbito jurídico.
Feminismo especulativo nas veredas pós-correlacionistas
Authors: Souza Ana Paula Lemes de
Published: January 2021

RESUMO:Este trabalho discute novas possibilidades do feminismo no movimento filosófico denominado realismo especulativo, na vertente de Quentin Meillassoux, de forma a oxigenar a epistemologia feminista contemporânea, que se encontra em clausura metafísica. Se, pré-Kant, o feminismo se encontrava enclausurado na postura objetivista, com a essencialização da mulher como imperfeita, por outro lado, pós-Kant, a mulher se encontra reduzida à verdade subjetivista da ordem epistêmica, gerando outras essencializações. O artigo propõe nova visão para se pensar o feminismo póscorrelacionista, com a ascensão de outra forma de reflexão ontológica: através da cosmontologia, uma compreensão do sexo, do gênero e da sexualidade nem melhor e nem pior, mas apenas diferente, que provoca a reontologização das ciências humanas pelo reconhecimento de outras grafias e modos de existência.
The Puzzle of Immunosuppressive Drugs
Authors: Chaba Anis , Dekeyser Manon , Oniszczuk Julie , Durrbach Antoine ,   Assistance Publique-Hôpitaux de Paris, Nephrology and Renal Transplantation Department, Groupe Hospitalier Henri-Mondor/Albert-Chenevier, Créteil, France,   UMRS 1186, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France
Published: January 2021

Kidney transplantation has become the preferred treatment option in end-stage chronic renal failure as it provides significant improvements over dialysis in terms of both quality and duration of life. Even after several randomized studies conducted in the last 20 years, the combination of CNI, MMF, and steroids continues to be considered the gold standard for kidney transplantation. However, novel molecules aimed at minimizing renal and cardiovascular toxicity, particularly with CNI sparing, are being identified. The present review assesses various such molecules available currently and briefly discusses the existing combination strategies and novel perspectives for the redesigning of protocols based on our novel therapeutic arsenal.
Online Self-Determination Toolkit for Youth With Disabilities: Protocol for a Mixed Methods Evaluation Study
Authors: Lindsay Sally , Kosareva Polina , Sukhai Mahadeo , Thomson Nicole , Stinson Jennifer
Published: January 2021

Background

Youth with disabilities encounter many challenges during their transition to adulthood including finding employment. Jobs are often inaccessible, and youth often face a lack of support, discriminatory attitudes, and sometimes low self-confidence. Therefore, it is critical to help youth enhance their self-determination skills to advocate for their needs in the workplace.

Objective

The aim of this paper is to describe how an online toolkit aimed to improve self-determination in advocating for needs, including disability disclosure and accommodation requests to employers, was co-created with youth with disabilities.

Methods

We will use a mixed method design in which qualitative data (ie, focus groups and mentored discussion forum) are collected to understand the contextual factors during the intervention that could affect outcomes or explain results through the pre-post questionnaires. Fifty youths with disabilities aged 15 to 24 years will be recruited.

Results

Data collection is in progress. Planned analyses include focus groups and pre-post surveys to determine the impact of the intervention on self-determination. A qualitative content analysis of the focus groups and all open-ended survey questions will be conducted to understand the impact of the toolkit.

Conclusions

Our online toolkit includes evidence-informed content that was co-created with youth who have a disability. It has potential for educational and vocational programming for youth with disabilities.

International Registered Report Identifier (IRRID)

PRR1-10.2196/20463
What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask
Authors: Kohane Isaac S , Aronow Bruce J , Avillach Paul , Beaulieu-Jones Brett K , Bellazzi Riccardo , Bradford Robert L , Brat Gabriel A , Cannataro Mario , Cimino James J , García-Barrio Noelia , Gehlenborg Nils , Ghassemi Marzyeh , Gutiérrez-Sacristán Alba , Hanauer David A , Holmes John H , Hong Chuan , Klann Jeffrey G , Loh Ne Hooi Will , Luo Yuan , Mandl Kenneth D , Daniar Mohamad , Moore Jason H , Murphy Shawn N , Neuraz Antoine , Ngiam Kee Yuan , Omenn Gilbert S , Palmer Nathan , Patel Lav P , Pedrera-Jiménez Miguel , Sliz Piotr , South Andrew M , Tan Amelia Li Min , Taylor Deanne M , Taylor Bradley W , Torti Carlo , Vallejos Andrew K , Wagholikar Kavishwar B ,   The Consortium For Clinical Characterization Of COVID-19 By EHR (4CE), Weber Griffin M , Cai Tianxi
Published: January 2021

Coincident with the tsunami of COVID-19–related publications, there has been a surge of studies using real-world data, including those obtained from the electronic health record (EHR). Unfortunately, several of these high-profile publications were retracted because of concerns regarding the soundness and quality of the studies and the EHR data they purported to analyze. These retractions highlight that although a small community of EHR informatics experts can readily identify strengths and flaws in EHR-derived studies, many medical editorial teams and otherwise sophisticated medical readers lack the framework to fully critically appraise these studies. In addition, conventional statistical analyses cannot overcome the need for an understanding of the opportunities and limitations of EHR-derived studies. We distill here from the broader informatics literature six key considerations that are crucial for appraising studies utilizing EHR data: data completeness, data collection and handling (eg, transformation), data type (ie, codified, textual), robustness of methods against EHR variability (within and across institutions, countries, and time), transparency of data and analytic code, and the multidisciplinary approach. These considerations will inform researchers, clinicians, and other stakeholders as to the recommended best practices in reviewing manuscripts, grants, and other outputs from EHR-data derived studies, and thereby promote and foster rigor, quality, and reliability of this rapidly growing field.