bluuebunny/crossref_metadata_2025 huggingface dataset:
In defence of constitutive rules
Authors: Roversi Corrado
Published: October 2021

Although the notion of constitutive rule has played an important role in the metaphysical debate in social and legal philosophy, several authors perceive it as somewhat mysterious and ambiguous: the idea of a specific kind of rules that are supposed to be “magically” constitutive of reality seems suspicious, more a rationalistic fiction than a genuine explanation. For these reasons, reductionist approaches have been put forward to deflate the explanatory role of this notion. In this paper, I will instead try to defend constitutive rules. My thesis is that the notion of constitutive rule is explanatorily helpful because it gives a complete account of an important phenomenon in the social and legal domain, namely, that of artifactual entities endowed with statuses that can have emergent normative properties. Conceiving of these entities as rule-constituted artifacts is an important part of what H. L. A. Hart called “the internal point of view” toward law, and for this reason constitutive rules should be included in an explanation of that point of view as an integral part of the life of institutions. The structure of my argument will be as follows. First, I will provide an example of an important phenomenon in the internal point of view, namely, the fact that individuals can have normative reactions not about the specific regulation of an institution but about its underlying purpose and rationale—what in the legal domain is called the ratio of a norm. Then I will identify two reductionistic approaches on constitutive rules. The first approach is exemplified by Brian Epstein’s idea that the phenomena explained by constitutive rules are better explained in terms of metaphysical (grounding/anchoring) relations. The second kind of reductionism is instead exemplified by the idea (held by several authors, among whom Alf Ross, Riccardo Guastini, Frank Hindriks, and Francesco Guala) that the phenomena explained by constitutive rules can be accounted for in terms of regulative rules plus a certain terminology. I will try to show that neither of these approaches can explain normative reactions to theratioof an institution from an internal point of view: While the first cannot explain the fact that the reaction is strongly normative, the second cannot explain the fact that the reaction is about theratioof a normative entity. Constitutive rules can instead explain both things and should be preserved as an important notion for the analysis of institutional ontology. By way of constitutive rules we create something: immaterial, rule-based institutional artifacts that can have emergent normative properties.
Characterisation of autophagy disruption in the ileum of pigs infected with Lawsonia intracellularis
Authors: Salvesen Hamish A. , Sargison Fiona A. , Archibald Alan L. , Ait-Ali Tahar
Published: October 2021

Lawsonia intracellularis is the aetiological agent of proliferative enteropathy, an enteric disease endemic in swine. Survival in its intracellular niche of the ileum epithelial lining requires the capacity to subvert, repress or exploit the host immune response to create an environment conducive to bacterial propagation. To better understand how L. intracellularis survives in its intracellular niche, we have performed an investigation into the dynamic relationship between infection and the host autophagy response by immunohistochemistry in experimentally infected porcine ileum samples.

Beclin1, a protein required early in the autophagy pathway was observed to be distributed with a basal to apical concentration gradient in the crypts of healthy piglets, whilst infected piglets were observed to have no gradient of distribution and an increase in the presence of Beclin1 in crypts with histological characteristics of L. intracellularis residence. Detecting microtubule-associated protein light chain 3 (LC3) is used as a method for monitoring autophagy progression as it associates with mature autophagosomes. For LC3 there was no notable change in signal intensity between crypts with characteristic L. intracellularis infection and healthy crypts of uninfected pigs. Finally, as p62 is degraded with the internal substrate of an autophagosome it was used to measure autophagic flux. There was no observed reduction or redistribution of p62.

These preliminary results of the autophagy response in the ileum suggest that L. intracellularis affects autophagy. This disruption to host ileum homeostasis may provide a mechanism that assists in bacterial propagation and contributes to pathogenesis.
Towards the Optimization of Post-Laser Powder Bed Fusion Stress-Relieve Treatments of Stainless Steel 316L
Authors: Sprengel M. , Ulbricht A. , Evans A. , Kromm A. , Sommer K. , Werner T. , Kelleher J. , Bruno G. , Kannengiesser T.
Published: October 2021

The use of post-processing heat treatments is often considered a necessary approach to relax high-magnitude residual stresses (RS) formed during the layerwise additive manufacturing laser powder bed fusion (LPBF). In this work, three heat treatment strategies using temperatures of 450 °C, 800 °C, and 900 °C are applied to austenitic stainless steel 316L samples manufactured by LPBF. These temperatures encompass the suggested lower and upper bounds of heat treatment temperatures of conventionally processed 316L. The relaxation of the RS is characterized by neutron diffraction (ND), and the associated changes of the microstructure are analyzed using electron backscattered diffraction (EBSD) and scanning electron microscopy (SEM). The lower bound heat treatment variant of 450 °C for 4 hours exhibited high tensile and compressive RS. When applying subsequent heat treatments, we show that stress gradients are still observed after applying 800 °C for 1 hour but almost completely vanish when applying 900 °C for 1 hour. The observed near complete relaxation of the RS appears to be closely related to the evolution of the characteristic subgrain solidification cellular microstructure.
Two Pituitary Neuroendocrine Tumors (PitNETs) with Very High Proliferation and TP53 Mutation — High-Grade PitNET or PitNEC?
Authors: Saeger Wolfgang , Mawrin Christian , Meinhardt Matthias , Wefers Annika K. , Jacobsen Frank
Published: October 2021

We report two pituitary neuroendocrine tumors (PitNETs) with very high Ki67 labeling indices, many mitoses and TP53 mutation (nearly all tumor cell nuclei were positive for p53). One of the tumors had bone and liver metastases. One was a corticotroph cell tumor; the other was a lactotroph tumor. The classification of these tumors is the subject of this discussion. Traditionally, pituitary carcinomas are only diagnosed by demonstration of metastases according to the 2017 WHO classification. In contrast, neuroendocrine neoplasms of the gastrointestinal tract and pancreas are classified as either well differentiated NETs that are graded as G1, G2, and G3 based on proliferation as determined by Ki67 indices of ≤ 3, 3–20 and > 20%, and/or < 2, 2–20, and > 20 mitoses per 10 high-power field respectively, or as neuroendocrine carcinomas (NECs) that are poorly differentiated neoplasms with mitoses > 20/HPF and/or a Ki67 index > 20%. With the reclassificiation of PitNETs, in our opinion, the adequate term for the well-differentiated corticotroph tumor that we report is a PitNET G3, whereas the undifferentiated prolactin tumor should be classified as PitNEC. This report expands the spectrum of pituitary neuroendocrine neoplasms.
Association between mood disorders and frequent emergency department use: a cross-sectional study
Authors: Fehlmann Christophe A. , Miron-Celis Marcel , Chen Yue , Perry Jeffrey , Eagles Debra
Published: October 2021

Objectives

Frequent emergency department (ED) use is a growing problem that is associated with poor patient outcomes and increased health care costs. Our objective was to analyze the association between mood disorders and the incidence of frequent ED use.

Methods

We used the Canadian Community Health Survey conducted by Statistics Canada, 2015–2016. Mood disorder was defined as depression, bipolar disorder, mania, or dysthymia. Frequent ED use was defined as 4 or more visits in the year preceding the interview. Multivariable log-binomial regression models were used to determine the associations between mood disorders and frequent ED use.

Results

Among the 99,009 participants, 8.4% had mood disorders, 80.3% were younger than 65, and 2.2% were frequent ED users. Mood disorders were significantly associated with the 1-year cumulative incidence of frequent ED use (RR = 2.5, 95% CI 2.2–2.7), after adjusting for several potential confounders.

Conclusions

This national survey showed that people with a mood disorder had a three-fold risk of frequent ED use, compared to people without mood disorder. These results can inform the development of policies and targeted interventions aimed at identifying and supporting ED patients with mood disorder.
Causal pattern test and cloze test: a study of L2 learners using distributed models of conceptual representation
Authors: Khatin-Zadeh Omid , Eskandari Zahra , Marmolejo-Ramos Fernando
Published: October 2021

The aim of this study was to investigate the cognitive processes involved in cloze passage and causal pattern tests. Two tests of causal patterns (one in Persian and one in English) and a cloze test were administered among a group of 30 participants. Correlations between participants’ scores were calculated. The results showed that there was a significant correlation between participants’ scores in each pair of the three tests. These results suggest that there might be similarity between causal pattern test and cloze test in terms of cognitive resources and cognitive operations that are employed during answering items of these tests. These similarities are described on the basis of distributed models of conceptual representation. Furthermore, it is proposed that there are some similarities between the strategies that can be employed by test takers to find the correct answers in these two types of test. The individuals who are better in simultaneous activation of various semantic properties, including semantic properties that are related to cause-effect relationships, are more successful in identifying causal patterns among various elements of a text.
Formal Models of Domestic Politics
Authors: Gehlbach Scott
Published: October 2021

Formal Models of Domestic Politics offers a unified and accessible approach to canonical and important new models of politics. Intended for political science and economics students who have already taken a course in game theory, this new edition retains the widely appreciated pedagogic approach of the first edition. Coverage has been expanded to include a new chapter on nondemocracy; new material on valance and issue ownership, dynamic veto and legislative bargaining, delegation to leaders by imperfectly informed politicians, and voter competence; and numerous additional exercises. Political economists, comparativists, and Americanists will all find models in the text central to their research interests. This leading graduate textbook assumes no mathematical knowledge beyond basic calculus, with an emphasis placed on clarity of presentation. Political scientists will appreciate the simplification of economic environments to focus on the political logic of models; economists will discover many important models published outside of their discipline; and both instructors and students will value the classroom-tested exercises. This is a vital update to a classic text.
On Hedgehogs and Marvelous Minds
Authors: Hill Austin “Chad” , Kersel Morag M. , Rowan Yorke M.
Published: October 2021

The collection of 3D point data is a common bottleneck for archaeological excavations despite an increasing range of powerful spatial data collection technologies. Total stations often require a dedicated operator, and they are optimal for excavation-level data collection over relatively short line-of-site distances. Precision Global Navigation Satellite Systems (GNSS) require reliable communication with constellations of distant satellites and may not be accurate enough for all data recording contexts. A new category of spatial data collection hardware, called Indoor Positioning Systems (IPS), or “indoor GPS,” has the potential to provide a more cost-effective and efficient approach to the collection of point data during excavations by making 3D point data collection widely available and accessible. Additionally, such systems may allow greater detail in digital field data recording by enabling the collection of shape data via continuous recording. In this article, we present one such IPS system—the Marvelmind IPS—discuss its potential value and limitations, and provide a case study of a field test of the system at the Chalcolithic (4600–3600 BC) site of Horvat Duvshan, Israel.
Algorithmic Fairness and the Situated Dynamics of Justice
Authors: Fazelpour Sina , Lipton Zachary C. , Danks David
Published: October 2021

Machine learning algorithms are increasingly used to shape high-stake allocations, sparking research efforts to orient algorithm design towards ideals of justice and fairness. In this research on algorithmic fairness, normative theorizing has primarily focused on identification of “ideally fair” target states. In this paper, we argue that this preoccupation with target states in abstraction from the situated dynamics of deployment is misguided. We propose a framework that takes dynamic trajectories as direct objects of moral appraisal, highlighting three respects in which such trajectories can be subject to evaluation in relation to their (i) temporal dynamics, (ii) robustness, and (iii) representation.
Seven observations and research questions about Open Design and Open Source Hardware
Authors: Bonvoisin Jérémy , Mies Robert , Boujut Jean-François
Published: October 2021

‘Openness’ is one of the key concepts brought forward by postindustrial narratives questioning the modern repartition of roles between industries and customers. In these narratives, citizen participation in design and intellectual property management based on open source principles are the promise of more sustainable production models. In this context, openness in product design and development has been the object of growing interest and experimentation from academia, businesses and grassroots communities. As a result, numerous concepts emerged that attempt to grasp the essence of this phenomenon, unfortunately leading to overlapping, conflicting or speculative depictions. In this article, we share the understanding we gained throughout 6 years of research on Open Design and Open Source Hardware and attempt to make the difference between myths and facts. We depict an enthusiastic but realistic picture of Open Design and Open Source Hardware practices as we could observe them and deliver a structured framework to situate concepts and their differences. From this, we share seven observations leading to seven corresponding research questions and establish a research agenda to stimulate further investigations into this socially relevant and potentially ground-breaking phenomenon.
Assessing compliance of infection prevention mitigation strategies in hospital construction and renovation
Authors: Buchanan Mark O. , Sickbert-Bennett Emily E. , DiBiase Lauren M. , Weber David J.
Published: October 2021

Hospital-associated fungal infections from construction and renovation activities can be mitigated using an infection control risk assessment (ICRA) and implementation of infection prevention measures. The effectiveness of these measures depends on proper installation and maintenance. Consistent infection prevention construction rounding with feedback is key to ongoing compliance.
Person Under Investigation: Detecting Malingering and a Diagnostics of Suspicion in Fin-de-Siècle Britain
Authors: Krishnan Lakshmi
Published: October 2021

In 1889, TheBritish Medical Journalpublished a piece titled, “Detective Medicine,” which describes feats of medical detection performed by physicians attending malingering prisoners. Though simulating illness had a long history, the medicalization of malingering at thefin de siècleled to a proliferation of such case histories and cheerful records of pathological feigners thwarted.
“The Offspring of Drunkards”: Gender, Welfare, and the Eugenic Politics of Birth Control and Alcohol Reform in the United States
Authors: Thompson Lauren MacIvor
Published: October 2021

The social politics of women’s alcohol use is controversial given current debates over maternal-fetal health, fetal alcohol syndrome, and debates about welfare. Exploring the early twentieth century intersections of Prohibition, birth control reform, and alcohol politics reveals the historical roots of current recommendations surrounding women, alcohol, and public assistance.
Doubt & Social Policy: The Long History of Malingering in Modern Welfare States
Authors: Goldberg Daniel S.
Published: October 2021

This essay explores the long Western history of anxieties about feigned illness connected specifically to social policy. There is a remarkable consistency of such anxieties across time, as they appear in almost every major historical period in the West since the Middle Ages.
Pandemic “Disability Cons”
Authors: Dorfman Doron
Published: October 2021

Disability rights law has made issues of access and accommodations much more visible in American life. Yet a byproduct of the increased awareness of disability rights has been “fear of the disability con,” that is, the common apprehension that people are abusing the law to gain an unfair advantage. Many times, this moral panic creates an invisible, oft-overlooked barrier for people with disabilities who desire to utilize their rights. They either are refused the right altogether or give up asking for it in the first place because they are afraid of being accused of being fakers. This Article shows how fear of the disability con surfaced along the progression of the COVID-19 pandemic. It describes the schism between the ways in which people with disabilities generally fared under the pandemic and some popular perceptions regarding the “privileges” they allegedly received because of their protected legal status. Those so-called privileges include mask exemptions, vaccination priority, and permission to continue remote work. The Article concludes with lessons the COVID-19 pandemic experience can teach us about the nature and scope of the fear of the disability con.
Transparency of Regulatory Data across the European Medicines Agency, Health Canada, and US Food and Drug Administration
Authors: Egilman Alexander C. , Kapczynski Amy , McCarthy Margaret E. , Luxkaranayagam Anita T. , Morten Christopher J. , Herder Matthew , Wallach Joshua D. , Ross Joseph S.
Published: October 2021

Based on an analysis of relevant laws and policies, regulator data portals, and information requests, we find that clinical data, including clinical study reports, submitted to the European Medicines Agency and Health Canada to support approval of medicines are routinely made publicly available.
Informed Consent for Secondary Research under the New NIH Data Sharing Policy
Authors: Rothstein Mark A.
Published: October 2021

The new NIH data sharing policy, effective January 2023, requires researchers to submit a data management and data sharing plan in their grant application. Expanded data sharing, encouraged by NIH to facilitate secondary research, will require informed consent documents to explain data sharing plans, limitations, and procedures.
Developing an Innovative Pandemic Treaty to Advance Global Health Security
Authors: Gostin Lawrence O. , Meier Benjamin Mason , Stocking Barbara
Published: October 2021

Recognizing marked limitations of global health law in the COVID-19 pandemic, a rising number of states are supporting the development of a new pandemic treaty. This prospective treaty has the potential to clarify state obligations for pandemic preparedness and response and strengthen World Health Organization authorities to promote global health security. Examining the essential scope and content of a pandemic treaty, this column analyzes the policymaking processes and substantive authorities necessary to meet this historic moment.
Dietary supplementation with casein glycomacropeptide, leucine and tryptophan reduces plasma amino acid levels in men
Authors: Larsen Erik Roj , Juel Anette , Jensen Erik , Hollyer Tristan R. , Wegener Gregers
Published: October 2021

Background:

The treatment of mania in bipolar disorders needs to be more efficient, as the manic condition creates severe problems for the patient when it comes to work, finances, relationships and health. This proof-of-concept study examines to what extent casein glycomacropeptide (CGMP) may reduce the precursors of dopamine, phenylalanine and tyrosine, in plasma, and therefore be a potential new intervention to treat acute manic episodes.

Method:

The study was designed as a double-blind randomised dose–response study of CGMP (with added leucine and tryptophan) in 15 healthy men, receiving 3 different doses of CGMP with an interval of at least 14 days.

Results:

Administration of CGMP produced a dose-dependent depletion of plasma aromatic amino acids. The total area under the curve of plasma ratios of phenylalanine–tyrosine compared to the level of leucine–isoleucine–valine–-tryptophan was CGMP (20 g): 3.648 [SE:0.3281]; CGMP (40 g): 2.368 [SE:0.1858]; and CGMP (60 g)1.887 [SE:0.2591]. A comparison of the groups showed a dose-dependent statistical difference, with a one-way ANOVA summary (Dunnett) F = 11.87, p = 0.0003, CGMP 20 g versus CGMP 40 g, p = 0.0042, CGMP 20 g versus CGMP 60 g, p = 0.0002. No significant side effects were observed.

Conclusions:

This study demonstrate CGMP is a well-tolerated and effective mixture, and that 60 g of CGMP produced the highest depletion of plasma aromatic amino acids (phenylalanine and tyrosine). The effect seems to be highest after 3–4 h. We therefore conclude that this dose should be the one considered for future studies involving CGMP in humans.
Making Reliable Persons: Managing Descent and Genealogical Computation in Pakistan
Authors: Hashmi Zehra
Published: October 2021

In 2016, the National Database and Registration Authority (NADRA), which produces Pakistan’s biometric-based national identity card, publicly announced that it would be “re-verifying” identity cards for a national security drive. NADRA relies on the documentation of descent-based relations, including genealogical charts (shajarah-yi-nasab), for its verification procedures. In so doing, NADRA asks the difficult question of who belongs where and who is a citizen, based on who they used to be. This article historically traces the movement of genealogies between the realm of the familial and the bureaucratic. I examine how the colonial state deployed genealogical expertise and how this formation folds into the postcolonial present in ways that shape capacities for genealogy-based claims to identity. It demonstrates how what I term “genealogical computation” extends beyond the domain of governance into articulations of identity that seek to establish status, reliability, and trustworthiness. I argue that “reliable persons” are produced in contemporary Pakistan through an encounter between the genealogical computations of citizens and the expectations of an ethno-securitized state. This encounter is borne out of a rehearsed relation where one’s genealogy, which has held a particular meaning in relation to one kind of security state (the colonial), is now asked to take on another.
Containing COVID-19 in the Democratic Republic of the Congo: Government Measures and Women's Compliance
Authors: Jacobs Carolien , Kyamusugulwa Patrick Milabyo , Katembera Rachel Sifa , Kintuntu Henri
Published: October 2021

This article concerns the unfolding COVID-19 pandemic in the Democratic Republic of the Congo. It analyses the sanitary measures that the government has taken to respond to the pandemic since March 2020, the way these measures are enforced, and the extent to which women comply with the measures. The article draws from desk research and empirical data from the eastern city of Bukavu, where the research team conducted 134 structured interviews. The findings show widespread willingness to comply with some of the main measures because of fear of sanctions, fear of the pandemic and because of trust in the state or church. The article argues that many women hold the state accountable for the success in containing the virus, but also criticize the state for not providing livelihood assistance during the state of emergency. Further research is needed to assess the impact of COVID-19 on state legitimacy.
Electoral Governance and Human Rights Amid Pandemics in Africa: Key Lessons from the Early COVID-19 Experience
Authors: Mohee Mansha
Published: October 2021

Over 25 African countries had planned elections for 2020. In the face of the onset of the COVID-19 pandemic in March, states resorted to one of two courses of action: adherence to planned electoral timelines in the shadow of the outbreak, which largely led to record low voter turnouts and hastened the spread of the virus; or adjourning elections with ill-defined election programming, constitutional tensions and unrest over delayed polls. The global health crisis not only frustrated the organization of the electoral process but set severe challenges to democracy, the rule of law and human rights in the region at a time of landmark elections, notably in Ethiopia, Burundi and Malawi. This article analyses initial state responses in electoral administration in light of international electoral norms, and interrogates the role of national and regional mechanisms in securing safe, inclusive, timely, free and fair elections amid new infectious disease outbreaks.
Magnetic resonance imaging of the internal auditory meatus for vestibular schwannoma in ENT practice: a retrospective analysis with literature and guidelines review
Authors: Perera M B , Janjua N , Swaminathan R , Apthorp C , Al-Deerawi H B
Published: October 2021

Objectives

Magnetic resonance imaging scans of the internal acoustic meatus are commonly requested in the investigation of audio-vestibular symptoms for potential vestibular schwannoma. There have been multiple studies into protocols for requesting magnetic resonance imaging for vestibular schwannoma, but none have been reported based on UK National Institute for Health and Care Excellence guidelines for investigating audio-vestibular symptoms. This study intended to identify the local magnetic resonance imaging detection rates and patterns of vestibular schwannoma, and to audit the conformity of scan requests with the National Institute for Health and Care Excellence guidelines, with a review of relevant literature.

Method

A retrospective analysis of 1300 magnetic resonance imaging scans of the internal acoustic meatus, compared against National Institute for Health and Care Excellence guidelines, was conducted over two years.

Results and conclusion

Sixteen scans were positive for vestibular schwannoma, with a detection rate of 1.23 per cent. All positive cases fit the guidelines; three of these could have been missed using other criteria. A total of 281 requests did not meet the guideline criteria but revealed no positive results, supporting the use of National Institute for Health and Care Excellence guidelines in planning magnetic resonance imaging scans for audio-vestibular symptoms.
Emerging themes in necrotising otitis externa: a scoping review of the literature from 2011 to 2020 and recommendations for future research
Authors: Stapleton E , Watson G
Published: October 2021

Objective

Necrotising otitis externa is an invasive, infective condition, with minimal evidence underpinning its diagnosis and management. This work aimed to analyse literature from the past decade, to identify emerging themes and important topics for future research.

Methods

A robust literature search and review were conducted by two researchers. Sixty studies were filtered into the final review. A grounded theory approach was used to identify core themes. Data within these themes formed the basis of the review.

Results

There is no consensus regarding a clinical definition or outcome measures of necrotising otitis externa, and there exists no level 1, 2 or 3 evidence to diagnose, investigate, monitor or treat necrotising otitis externa. Emerging themes in the literature direct researchers to important topics for future clinical trials, including risk factors, microbiological culture, management strategies and radiology.

Conclusion

In order to optimise understanding and management of necrotising otitis externa, future research requires robust clinical trials and consistently reported outcome measures.
Contrastive explanation: a structural-model approach
Authors: Miller Tim
Published: October 2021

This paper presents a model of contrastive explanation using structural casual models. The topic of causal explanation in artificial intelligence has gathered interest in recent years as researchers and practitioners aim to increase trust and understanding of intelligent decision-making. While different sub-fields of artificial intelligence have looked into this problem with a sub-field-specific view, there are few models that aim to capture explanation more generally. One general model is based on structural causal models. It defines an explanation as a fact that, if found to be true, would constitute an actual cause of a specific event. However, research in philosophy and social sciences shows that explanations are contrastive: that is, when people ask for an explanation of an event—the fact—they (sometimes implicitly) are asking for an explanation relative to some contrast case; that is, ‘Why P rather than Q?’. In this paper, we extend the structural causal model approach to define two complementary notions of contrastive explanation, and demonstrate them on two classical problems in artificial intelligence: classification and planning. We believe that this model can help researchers in subfields of artificial intelligence to better understand contrastive explanation.
Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence
Authors: Nishimura Yusuke , Højfeldt Grith , Breen Leigh , Tetens Inge , Holm Lars
Published: October 2021

Adequate protein intake is essential for the maintenance of whole-body protein mass. Different methodological approaches are used to substantiate the evidence for the current protein recommendations, and it is continuously debated whether older adults require more protein to counteract the age-dependent loss of muscle mass, sarcopenia. Thus, the purpose of this critical narrative review is to outline and discuss differences in the approaches and methodologies assessing the protein requirements and, hence, resulting in controversies in current protein recommendations for healthy older adults. Through a literature search, this narrative review first summarises the historical development of the Food and Agriculture Organization/World Health Organization/United Nations University setting of protein requirements and recommendations for healthy older adults. Hereafter, we describe the various types of studies (epidemiological studies and protein turnover kinetic measurements) and applied methodological approaches founding the basis and the different recommendations with focus on healthy older adults. Finally, we discuss important factors to be considered in future studies to obtain evidence for international agreement on protein requirements and recommendations for healthy older adults. We conclude by proposing future directions to determine ‘true’ protein requirements and recommendations for healthy older adults.
Teaching and Evaluation Methods of the Use of the Tourniquet in Severe Limb Bleeding among Health Care Professionals: A Systematic Review
Authors: Sobrido-Prieto María , Martínez-Isasi Santiago , Pérez-López Marta , Fernández-Méndez Felipe , Barcala-Furelos Roberto , Fernández-García Daniel
Published: October 2021

Introduction and Objectives:

Massive hemorrhage (MH) is a growing pathology in military settings and increasingly in civilian settings; it is now considered a public health problem in the United States with large-scale programs. Tourniquets are the fastest and most effective intervention in MH if direct pressure is not effective.

The Liaison Committee on Resuscitation (ILCOR) recognizes a knowledge gap in optimal education techniques for first aid providers. This review aims to describe training and evaluation methods for teaching tourniquet use to both health care and military professionals.

Methods:

The MEDLINE, CINAHL, WEB of Science, and Scopus databases were reviewed (from 2010 through April 2020). The quality of the selected studies was assessed using the Consolidated Standards of Reporting Trials (CONSORT) scale. Studies that met at least 65% of the included items were included. Data were extracted independently by two reviewers.

Results:

Ten of the 172 articles found were selected, of which three were randomized clinical trials. Heterogeneity was observed in the design of the studies and in the training and evaluative methods that limit the comparison between studies.

Conclusions:

The results suggest that the training strategies studied are effective in improving knowledge, attitudes, and practical skills. There is no universal method, learning is meaningful but research should be directed to find out which ones work best.
From administrative to political order? Global legal history, the organic law, and the constitution of mandate Syria, 1925–1930
Authors: Mestyan Adam
Published: October 2021

This article explores the making of the State of Syria after the dissolution of the Ottoman Empire. I argue that an event-based approach in global legal history offers a useful perspective for studying the transition from imperial to international and national systems. Drawing on new archival research in France and Saudi Arabia, I focus upon the creation of the 1928 Syrian constitution in the League’s mandate to show the administrative framework of political orders. First, I describe the French administrative logic through the story of the international ‘organic law’. Second, I describe the way the organic law necessitated the Syrian political constitution. The constrained constitutional process resulted in a clash and a compromise about a Muslim president between secularist republicans and exiled, Saudi-related Muslim monarchists. Global history can profit from this approach by rethinking decolonization as administrative reorganization and by focusing on dissenting, non-state actors in state-making.
Narrative and nuclear weapons politics: the entelechial force of the nuclear origin myth
Authors: Considine Laura
Published: October 2021

This paper contributes a novel way to theorise the power of narratives of nuclear weapons politics through Kenneth Burke's concept of entelechy: the means of stating a things essence through narrating its beginning or end. The paper argues that the Manhattan Project functions narratively in nuclear discourse as an origin myth, so that the repeated telling of atomic creation over time frames the possibilities of nuclear politics today. By linking Burke's work on entelechy with literature on narrative and eschatology, the paper develops a theoretical grounding for understanding the interconnection of the nuclear past, present, and future. The paper supports its argument by conducting a wide-ranging survey of academic and popular accounts of the development of the atomic weapon in the US Manhattan Project. It reveals a dominant narrative across these accounts that contains three core tropes: the nuclear weapon as the inevitable and perfected culmination of humankind's tendency towards violence; the Manhattan Project as a race against time; and the nuclear weapon as a product of a fetishized masculine brilliance.
Maternal childhood trauma and prenatal stressors are associated with child behavioral health
Authors: Ahmad Shaikh I. , Rudd Kristen L. , LeWinn Kaja Z. , Mason W. Alex , Murphy Laura , Juarez Paul D. , Karr Catherine J. , Sathyanarayana Sheela , Tylavsky Frances A. , Bush Nicole R.
Published: October 2021

Maternal adversity and prenatal stress confer risk for child behavioral health problems. Few studies have examined this intergenerational process across multiple dimensions of stress; fewer have explored potential protective factors. Using a large, diverse sample of mother–child dyads, we examined associations between maternal childhood trauma, prenatal stressors, and offspring socioemotional-behavioral development, while also examining potential resilience-promoting factors. The Conditions Affecting Neurocognitive Development and Learning and Early Childhood (CANDLE) study prospectively followed 1503 mother–child dyads (65% Black, 32% White) from pregnancy. Exposures included maternal childhood trauma, socioeconomic risk, intimate partner violence, and geocode-linked neighborhood violent crime during pregnancy. Child socioemotional-behavioral functioning was measured via the Brief Infant Toddler Social Emotional Assessment (mean age = 1.1 years). Maternal social support and parenting knowledge during pregnancy were tested as potential moderators. Multiple linear regressions (N= 1127) revealed that maternal childhood trauma, socioeconomic risk, and intimate partner violence were independently, positively associated with child socioemotional-behavioral problems at age one in fully adjusted models. Maternal parenting knowledge moderated associations between both maternal childhood trauma and prenatal socioeconomic risk on child problems: greater knowledge was protective against the effects of socioeconomic risk and was promotive in the context of low maternal history of childhood trauma. Findings indicate that multiple dimensions of maternal stress and adversity are independently associated with child socioemotional-behavioral problems. Further, modifiable environmental factors, including knowledge regarding child development, can mitigate these risks. Both findings support the importance of parental screening and early intervention to promote child socioemotional-behavioral health.
A Scaling Approach for Retention Properties of Crystalline Rock: Case Study of the In‐Situ Long‐Term Sorption and Diffusion Experiment (LTDE‐SD) at the Äspö Hard Rock Laboratory in Sweden
Authors: Tachi Yukio , Ito Tsuyoshi , Gylling Björn
Published: October 2021

The in‐situ long‐term sorption and diffusion (LTDE‐SD) experiment performed at the Äspö Hard Rock Laboratory in Sweden aims at increasing knowledge of sorption and diffusion processes of radionuclides in natural fractures and granodiorite matrix under in‐situ conditions. This paper presents a comprehensive modeling exercise focusing on the scaling approach for sorption and diffusion parameters from laboratory to in‐situ conditions using the LTDE‐SD data set for six representative radionuclides. The near‐surface heterogeneities at both the fracture surface and rock matrix were evaluated by the conceptual model with high porosity, diffusivity, and sorption capacity, as well as their gradual changes at the near‐surface zones. The modeling results for non‐sorbing Cl‐36 and weak‐sorbing Na‐22 validated the model concept and parameter estimation of porosity and diffusivity by considering a 5‐mm‐thick disturbed zone with gradual parameter changes and an undisturbed matrix characterized by constant parameters. The effective diffusivities (De) of these cationic and anionic tracers showed typical cation excess and anion exclusion effects; however, the cation excess diffusion was more pronounced due to the heterogeneous pore networks in this granodiorite. The modeling results for high‐sorbing tracers (Cs‐137, Ra‐226, Ni‐63, and Np‐237) with different sorption mechanisms validated the scaling approaches of distribution coefficients (Kd) as a function of particle size and their relation to near‐surface disturbances. Sorption dependence on particle size could be understood in relation to different sorption mechanisms and mineralogical features. This modeling exercise provided key recommendations toward better scaling approaches for estimating reliable De and Kd parameters under in‐situ conditions.
Influence of Thermal Stratification on the Structure and Evolution of the Martian Core
Authors: Greenwood Sam , Davies Christopher J. , Pommier Anne
Published: October 2021

The apparent end of the internally generated Martian magnetic field at 3.6–4.1 Ga is a key event in Martian history and has been linked to insufficient core cooling. We investigate the thermal and magnetic evolution of the Martian core and mantle using parameterized models and considered three improvements on previous studies. First, our models account for thermal stratification in the core. Second, the models are constrained by estimates for the present‐day areotherm. Third, we consider core thermal conductivity, , values in the range 5–40 W as suggested by recent experiments on iron alloys at Mars core conditions. The majority of our models indicate that the core of Mars is fully conductive at present with core temperatures greater than 1940 K. All of our models are consistent with the range of W . Models with an activation volume of 6 (0) require a mantle reference viscosity of  Pa s.
Formation of Pancake, Rolling Pin, and Cigar Distributions of Energetic Electrons at the Dipolarization Fronts (DFs) Driven by Magnetic Reconnection: A Two‐Dimensional Particle‐In‐Cell Simulation
Authors: Huang Kai , Lu Quanming , Lu San , Wang Rongsheng , Wang Shui
Published: October 2021

A two‐dimensional particle‐in‐cell (PIC) simulation is performed to study the formation of the pitch angle distribution of energetic electrons at dipolarization fronts (DFs) driven by magnetic reconnection. The energetic electrons at DFs are originated from the lobe region, and experience a two‐step acceleration process at the reconnection x‐line and the DFs, respectively. Three kinds of pitch angle distributions commonly observed in the magnetotail, Pancake, Rolling pin, and Cigar distributions, are formed in sequence during the propagation of the DFs. In the early stage, Pancake distributions are formed through betatron acceleration. During this stage, the flux of energetic electrons with pitch angles around 0° and 180° is low because these electrons have no time to be reflected many times at the DFs to obtain sufficient Fermi acceleration. However, the electrons with pitch angles around 90° are difficult to be trapped around the DFs for a long time, and their flux saturates quickly; while the electrons with pitch angles around 0° and 180° can be trapped inside the closed field lines and they get continuous Fermi acceleration during the propagation of the DFs. Therefore, in the later stage, the flux of energetic electrons with pitch angles around 0° and 180° gradually increases and at last exceeds that of energetic electrons with pitch angles around 90°, forming Rolling pin and Cigar distributions in sequence.
Extracting Reliable P‐Wave Reflections From Teleseismic P Wave Coda Autocorrelation
Authors: Zhou Jinju , Zhang Wei
Published: October 2021

Recently, many studies have demonstrated the use of teleseismic P wave coda autocorrelation for imaging lithosphere structures. However, the reliability of the extracted reflections remains uncertain and a means of evaluation is lacking. In this study, we propose a velocity analysis method that conveniently solves this problem in place of a synthetic experiment. This method considers the average velocity used for the moveout correction as an unknown quantity and then uses a continuously varying average velocity for the moveout correction. Finally, this method obtains a stacked result that varies with the average velocity and the vertical two‐way travel time to produce a diagram. This method is similar to the velocity analysis method used in exploration seismology. In this diagram, reliable reflections correspond to focused energy clusters, while noise lacks this feature. Therefore, this method helps determine which reflections are reliable, while also finding the appropriate parameters for data processing. Synthetic data tests demonstrate the validity of this method as well as a test of field data for station BOSA in the Kaapvaal craton, South Africa, which illustrates the successful application of the method in the case of a sharp and flat Moho discontinuity. Finally, we applied the method to the NCISP‐6 dense array and observed obvious energy clusters, representing reflections from the Moho discontinuity in the results for most stations. The depth and shape of the Moho discontinuity determined by this test are consistent with receiver function results, which verify the robustness of this method in relatively complex applications.
Terrestrial and Atmospheric Controls on Surface Energy Partitioning and Evaporative Fraction Regimes Over the Tibetan Plateau in the Growing Season
Authors: Yang Chenyi , Ma Yaoming , Yuan Yuan
Published: October 2021

Land‐atmosphere interactions are an essential component of the climate system. However, no detailed description of the underlying effects of the surface forcing of the atmosphere has been established. In this study, GLEAM, MODIS, and ERA5 were the input set of multiple analysis algorithms, "segmentation" was the core idea of the analysis method. The study area is segmented into six surface response functional groups, and the multidimensional evaporation regime function was segmented into piecewise functions controlled by segment authoritative variables. Inspired by the surface heat balance equation and moisture‐limited, energy‐limited evaporation regimes, we chose soil moisture content and the net radiation flux to represent the moisture and energy status, respectively, and chose the leaf area index (LAI) to characterize the vegetation cover to investigate the primary effects of surface parameters on the energy partitioning of the land surface and evaporative regime. The results show that though a coupling strength 1.8 times greater was obtained when the LAI was used as the response variable instead of soil moisture, soil moisture was still the highest response variable in the regression tree analysis. This is consistent with the essence of the evaporative fraction and indicates that water should be the most fundamental response variable. The evaporative regime was subdivided from two phases into five phases according to the effects such as water extraction by vegetation, photosynthesis, soil shading, and roughness changes, each with an authoritative response variable.