bluuebunny/crossref_metadata_2025 huggingface dataset:
LIPID PRODRUG NANOPARTICLES CARRYING A MIMETIC PEPTIDE OF APOLIPOPROTEIN A-II TARGET PANCREATIC ADENOCARCINOMA
Authors: Smith Ross , Xue Aiqun , Smith Sarah , Gill Anthony
Published: August 2024

The easy production, improved efficacy, and low toxicity of lipid prodrug nanoparticles (LPNP) represent a promising new drug delivery technology for pancreatic ductal adenocarcinoma (PDAC), when carrying gemcitabine (Gem-LPNP). This paper follows on from our previous study where we showed that lipid-based nanoparticles carrying a gemcitabine prodrug inhibit growth of human and cell-line PDAC xenografted onto mice. Using only 4.5mg/Kg of the clinical dose of gemcitabine in the prodrug, Gem-LPNP inhibited tumour growth as much as the significantly greater clinical dose of free gemcitabine (75-100mg/Kg). When apolipoprotein A-II (ApoA-II) was added to Gem-LPNP, growth was inhibited further. We determined that ApoA-II was actively targeting PDAC cells via the scavenger receptor-B1. To improve the safety and cost of our targeting nanoparticles, we have now designed a short peptide of ApoA-II (SQ31) to be attached to Gem-LPNP (Gem-LPNP-SQ31) and aimed to compare the effects of Gem-LPNP with Gem-LPNP-SQ31 in a murine xenograft model. Cell-line PDAC xenografts were implanted in one loin of twenty five immunodeficient mice. When the xenografts reached a measurable size, the mice were randomly assigned into five groups. They were given 200µL twice weekly of either 1) IV saline, 2) IP free gemcitabine 75mg/kg, 3) IV free gemcitabine 4.5mg/kg (equivalent dose to the nanoparticles), 4) IV Gem-LPNP or 5) IV Gem-LPNP-SQ31. Transdermal xenograft measures showed that over four weeks, Gem-LPNP-SQ31 inhibited PDAC growth as much as high-dose free gemcitabine, but using only a fraction of the high free gemcitabine dose. Although xenograft sizes after Gem-LPNP-SQ31 were significantly smaller than those after Gem-LPNP treatment, this was only a small difference. Both Gem-LPNP and Gem-LPNP-SQ31 xenografts were significantly smaller than xenografts after the equivalent low-dose free gemcitabine. There was no histological evidence of complications in the mice. It is concluded that the addition of SQ31 to Gem-LPNP increased the inhibition of PDAC growth and this nanoparticle construct should be developed for clinical evaluation in humans.
A Two-Year Longitudinal Study of Refractive Error and Ocular Biometry among Young Adults in Brazil
Authors: Cunha Celso , Marchezine Giovanna , Cunha Jessica , Lima Guilherme , Silva Ingrid , Rosa João , Ribeiro Mariana , Novaes Matheus , Carvalho Vinicius , Nascimento José , Iribarren Rafael
Published: August 2024

Background: The prevalence of myopia is increasing worldwide. Several studies were reported about myopia progression in the adult population with a high level of education. Objective: To investigate the changes in refractive errors, biometric measurements, and environmental variables among medical university students during two years in Brazil. Methods: A two-year longitudinal prospective study was proposed. Cycloplegic refractive examinations were conducted, and corneal topography and ocular optical biometry. The lens power was calculated by Bennett and Rozema’s formula. A questionnaire on lifestyle visual activities was applied. Only participants with normal ophthalmological exams were included in the study. Statistical significance was assessed at the level of 0.05. Results: One hundred twenty-eight students were eligible for the first exams and 89 (69.53%) completed the two-year follow-up. The mean age at baseline was 21.00 ± 1.92 years. Thirty-seven (41.57%) participants were males. Regarding refractive errors, 11 (12.36%) were hyperopic, 28 (31.46%) were emmetropic, 45 (50.56%) were myopic, and 5 (5.61%) were high myopic. There was a positive correlation between refraction and axial length in all groups, and a negative correlation with lens power. No significant two-year change in Km was found in all groups. The average of hours per day spent in outdoor and near-work activities were 1.36 ± 0.8 and 8.66 ± 1.77 h, respectively. Conclusion: The results showed that the main correlation to change in refraction was axial length. There were some cases of myopia progression in myopic students. The contribution of crystalline lens power for keeping slow myopia progression was significant.
Health inequalities and the COVID-19 pandemic: A qualitative study of Chinese people returning to China and diagnosed with COVID-19
Authors: Sun Wenxiu , Arbing Rachel , Zhang Qing , Ma Siyue , Zhang Lin , Chen Wei-Ti
Published: August 2024

Purpose: We aimed to describe the experiences of Chinese citizens who returned home during the COVID-19 pandemic and the COVID-19 infection experiences they had in China. A further aim was to explore health inequalities in healthcare and access to services as a consequence of the COVID-19 pandemic. Design: This qualitative study used in-depth interviews with 20 participants with confirmed COVID-19 upon returning to China. Methods: Purposively sampled participants were recruited from a COVID-19 designated facility in Shanghai, China, from June to July 2020. Semi-structured, in-depth interviews were conducted and a thematic analysis approach was used to analyze the data. Findings: Three main themes emerged from the interview study: access to services, COVID-19-related health care, and COVID-19-related stigma and discrimination. Regarding access to services, participants shared their experience of school closures and community shutdowns, and the difficulties encountered during their journey home to China. Regarding their experience with COVID-19-related health care, participants shared their experiences in foreign environments and access to COVID-19 care in China. In addition to experiencing discrimination overseas, similar discrimination from their networks in China was encountered by the study participants. Conclusions: Participants experienced health inequalities in accessing healthcare services and nursing during the COVID-19 pandemic and experienced stigma and discrimination related to COVID-19. Future studies should focus on developing culturally sensitive interventions to decrease public discrimination and provide suggestions to government policy makers on how to mount a public policy response during epidemics that does not increase health inequalities.
Shedding Misconceptions: The importance and impact of Drug allergy de-labelling
Authors: Nagarajan Sowmya
Published: August 2024

Drug allergies are often misunderstood, leading to misconceptions that can both hinder effective medical treatment and contribute to patient anxiety. It leads to prescription of other broad spectrum and expensive antibiotics which can be contributing to antimicrobial resistance, economic burden to the patient and the healthcare system. By the process of de-labelling, we can be championing for antimicrobial stewardship. De-labelling often involves a structured approach, including a detailed medical history, assessment of the initial allergic reaction, and consideration of potential testing, such as skin tests or supervised drug challenges. It’s a collaborative effort, requiring expertise from allergists in combination with the patient's healthcare team, leading to improved patient care and reduced constraints on medication choices. If these evaluations show that a patient can safely tolerate a drug they were previously labelled allergic to, the allergy label is removed, or de-labelled,it can pave the way forward to use it in future if required.
Incorporating Connective Tissue Growth Factor into Regenerative and Personalised Medicine for Tendon and Ligament Regeneration: A Systematic Review
Authors: Gan Quan , Choy Ker , Foo Chai , Li Zhang , Leong Pooi , Cheong Soon
Published: August 2024

Background: Tendon and ligament disorders particularly those of the weight bearing joints are associated with decreased physical activities affecting the quality of life. Current management includes conservative and surgical approaches requires a relatively long recovery time, in addition to the post-operative complications such as infection of the wound site and joint stiffness if managed surgically. Connective tissue growth factor is a type of growth factor expressed during second phase of the healing process and is responsible for tissue healing by stimulating the release of extracellular matrix responsible for tissue healing. Hence, the objective of this review is to identify available studies relating to the used of connective tissue growth factor in tissue culture for tendon and ligament healing. Methods: Studies were identified from PubMed Central, BioMed Central, ScienceDirect, and Wiley Online Library with the keywords: Connective Tissue Growth Factor ‘OR’ CTGF ‘OR’ CCN ‘AND’ Regeneration ‘AND’ Healing from the year 2019 to present, 2024. All literatures were reviewed in three phases by two reviewers. Results and Conclusion: There were only three articles which met our inclusion criteria. In general, connective tissue growth factor had been reported to be beneficial for ligament and tendon regeneration. However, the effective connective tissue growth factor dose for optimal ligament and tendon regeneration healing could not be determined due to the different cell source and delivery methods utilised among the identified articles.
Identification of a Novel SCN5A gene variant in a young female with atrioventricular canal defect in the absence of classical Brugada syndrome phenotype
Authors: Mondal Ritwick , Manna Rahul , Banerjee Emili , Benito-León Julián , Deb Shramana
Published: August 2024

Background: Brugada syndrome is generally considered a cardiac channelopathy disorder characterized by syncope or sudden cardiac death. The sodium voltage-gated channel alpha subunit 5 (SCN5A) gene is the most commonly mutated gene associated with Brugada syndrome. Recent discoveries of new variants of this gene, along with current guidance of family screening, have identified several asymptomatic carriers with potentially causative mutations. Case presentation: We present the case of a 25-year-old female patient without any family history of Brugada syndrome nor related congenital cardiovascular disorders, with an extensive atrioventricular canal defect, who tested positive for a novel heterozygous variant NM_198056.3: c.3169G>C (p. Asp1057 His) in the SCN5A gene. She had no history of syncope or aborted sudden cardiac death except for recurrent chest infections since her early childhood. Intriguingly, she did not show a type I Brugada electrocardiogram pattern. Conclusions: This report provides a novel heterozygous variant NM_198056.3: c.3169G>C (p. Asp1057 His) in the SCN5A gene, which may have a potential detrimental effect.
BiASE : Bidirectional Arrhythmia Sequence extractor
Authors: Satani Abhijeet , Barodia Param , Satani Bhoomi
Published: August 2024

Background: Identifying Arrhythmia for healthcare professionals is critical, considering time and effort and existing struggle with complex spatial and temporal artifacts. The current Machine Learning focuses on accurate classification instead of having a deeper look at the signal origination and cause of disease. Method: Addressing these issues, this paper presents Bidirectional Arrhythmia Sequence extractor, a unique deep learning model for Electrocardiogram -based arrhythmia classification. The three main parts are: 1) a Squeeze-and-Excitation Temporal Attention Module to model long-range temporal dependencies; 2) a Multi-Receptive Convolutional Module to extract spatial patterns at multiple scales; and 3) an Adaptive Class-Balanced Loss to minimize class imbalance. Result: The combination of using Multi-Receptive Convolutional Module and Squeeze-and-Excitation Temporal Attention Module helps the classification and identification of these electrocardiogram signals considering both the spatial and temporal factors and also use of Adaptive Class-Balanced Loss to dynamically adjusts class weights during training to emphasize underrepresented arrhythmia types. Conclusion: The proposed Bidirectional Arrhythmia Sequence extractor architecture advances electrocardiogram arrhythmia classification by learning discriminative spatio-temporal representations while handling data challenges. Bidirectional Arrhythmia Sequence extractor can improve clinical decision support and heart disease diagnosis.
Eye-tracking in Early Manifest Huntington’s Disease: Heterogeneity of Deficits in Inhibitory and Fronto-Executive Control
Authors: Júlio Filipa , Januário Cristina , Castelo-Branco Miguel , Caetano Gina
Published: August 2024

Objectives: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder that affects first basal ganglia and fronto- striatal circuitry. Cognitive decline and inhibitory control deficits are more subtle in the early stages of manifest disease, yet relevant to track disease progression. The current study aims to underpin and characterize the dysfunction of oculomotor inhibitory control mechanisms and executive function through working memory demands on fronto-executive load in a cohort of early manifest HD (Early-HD). Methods: A comprehensive battery of neuropsychological tests was applied to assess cognitive functioning in 14 Early-HD and 22 Control participants. Oculomotor function was studied using an experimental paradigm comprising four oculomotor tasks: prosaccade, antisaccade, 1- or 2-back memory prosaccade, and 1- or 2-back memory antisaccade. The estimated metrics were success rate, direction errors, timing errors, and the primary saccade latency. Results: The Early-HD group demonstrated cognitive deficits in visual and verbal memory, executive function, attention, visual perception, and verbal and non-verbal IQ domains. Regarding oculomotor performance, the clinical group had a decreased success rate and increased percentage of direction errors and early premature saccades while exhibiting faster response times than the Control group in the 1- or 2-back memory antisaccade task. Conclusions: Our results demonstrate overt oculomotor dysfunction in Early-HD since inhibitory control mechanisms are necessary to perform the task. Furthermore, increasing working memory demands and fronto-executive load enhances impulsive response patterns. The dysfunction in goal-oriented oculomotor behavior, including more automatized responses and deficits in inhibition, is present in Early- HD patients with cognitive deficits but who remain functional and autonomous. These findings reinforce the notion that fronto-striatal impairment is a crucial event in HD and that more automatized oculomotor evaluation procedures help identify and stratify deficits in early manifest disease. Keywords: Huntington’s disease, manifest stage, oculomotor performance, inhibition, fronto-executive load
The Associations between Attachment, Adverse Childhood Experiences and Re-Victimization in Patients with a Psychosis Spectrum Disorder
Authors: Bussel E. , Wierdsma A. , Aken B. , Willems I. , Mulder C.
Published: August 2024

Background: As attachment and trauma have been shown to be potential determinants of psychotic dysregulation and of recovery from psychosis, it is essential to better understand the associations between attachment, adverse childhood experiences (ACE) and re- victimization in patients with a psychosis spectrum disorder. Aims: To examine whether the occurrence and severity of ACE and re-victimization are differently associated with the various attachment categories (secure, dismissive, preoccupied and fearful-avoidant) within a population of patients with a psychosis spectrum disorder. Method: In this explorative study in a sample of 273 patients with psychotic disorder, we described the prevalence and severity of ACE and re-victimization and their associations with the four attachment styles in question (secure, dismissive, preoccupied and fearful- avoidant or disorganized). Results: The highest ACE frequencies were found for emotional abuse (36.6%), emotional neglect (36.6%) and domestic violence (32.6%). As well as emotional and physical abuse, emotional and physical neglect were noticeably more frequent in all the insecure attachment classes than in the secure attachment class. Household substance abuse was high in the fearful-avoidant attachment class and parental divorce in the dismissive and fearful- avoidant attachment classes. Re-victimization occurred in 64.5% of the total sample, with a repeatfrequency of 91.6% in the severe ACE class. The fearful-avoidant attachment style was very frequent (33.3%) in the severe re- victimization class. Conclusion: Attachment functioning, interpersonal childhood trauma and re-victimization all deserve greater recognition in populations with a psychosis spectrum disorder. If their associations are well understood, future treatment might be improved.
Contextual modeling of collective diagnosis of chronic inflammatory bowel
Authors: Brézillon Patrick
Published: August 2024

The paper presents results on the modeling of contextual reasoning of Anatomy and Cytology Pathologists in chronic inflammatory bowel disease diagnosis. The diagnosis is modeled in the Contextual-Graphs formalism that offers a uniform representation of knowledge, reasoning and context. The diagnosis is considered as a mental model that is extracted of a mental representation expressing pathologists’ experience on this diagnosis. Building and development of the mental model are intertwined during the contextual nonlinear reasoning held during diagnosis. Modeling of contextual reasoning is particularly relevant for decision-makers that cannot work on formal model. The Contextual-Graphs formalism was applied in several domains, including medicine, for different aspects of cancer (breast, lung, prostate) and at different levels from a synthesis on breast cancer diagnosis to mitosis identification on digital slides, the modeled diagnosis here being between them.
A Review of Metastasis-Directed Therapy in Oligometastatic Gastrointestinal Cancers
Authors: Newman Neil
Published: August 2024

This review provides an overview of the current understanding regarding the role of metastasis-directed therapy (MDT) in patients with oligometastatic gastrointestinal cancers. A review of clinical data was conducted to describe patient outcomes associated with the use of local therapy alone or in combination with systemic therapy to gastrointestinal oligometastases. Included cancers were esophagus, liver, pancreas, colorectal, and anal canal. Radiotherapy was the most common MDT employed across studies although surgical resection and transarterial ablation were also used. Present data suggest that local therapies should be considered in the treatment of oligometastatic gastrointestinal malignancies for appropriate patients. MDT may be associated with improved overall survival, progression-free survival, particularly for esophageal and colorectal cancers. Enhanced disease control has also been seen for hepatocellular and pancreatic cancers with limited adverse events. The data highlight the increasing impact of locoregional management of oligometastatic disease through multiple treatment modalities. Targeted approaches involving radiotherapy and surgical resection can enhance clinical response to systemic therapy and improve patient outcomes. Future randomized clinical trials will further establish the role of MDT in patients with oligometastatic GI cancers.
Editorial 12-2
Authors: Moreno-Romero Camilo O. , Cortés-García Cristian Alejandro
Published: August 2024

Editorial 12-2
“It is in spanish”: colaboración como herramienta de transformación educativa
Authors: Ávila Zarate Adriana Ines , Krause Gladys
Published: August 2024

The present approach describes the work carried out by two educators in two different geographical, cultural, and linguistic contexts: Colombia and the United States. As educators, they share a) the responsibility of preparing future preschool and primary school teachers, and b) an interest in creating educational experiences that foster an expansion of perspectives on what it means to be a teacher. The authors propose a collaborative framework and suggest its implementation in teacher education. The proposal describes three years of collaborative work creating spaces for future teachers in an Early Childhood Education program in Colombia and a teacher education program for elementary school teachers in the United States to interact and collaborate with each other on the development and implementation of various educational approaches in mathematical contexts. The proposal suggests the design and implementation of a framework for collaboration aimed at transforming educational practices.
Warthin like papillary thyroid carcinoma: A rare case report
Authors: Goyal Anjali , Shah Riya , Halpati Monali , Damor Kinjal , Updhyaya Prahari Nayankumar
Published: August 2024

Papillary thyroid carcinoma (PTC) is the most frequent endocrine malignancy with a variety of histopathological presentations. Warthin like papillary thyroid carcinoma (WL-PTC) is an uncommon variant that is recognized as a distinct subtype of PTC in WHO Classification (5 edition-2022) of thyroid tumors.We report a case of female patient aged 36-year-old presented with complaint of swelling over anterior midline of neck region for 6 months which was gradually increasing in size. The ultrasonography report revealed possibility of malignancy TIRADS- 5. The patient underwent FNAC which was reported as papillary thyroid carcinoma- Bethesda Category V. The total thyroidectomy was performed, the histopathological report stated Papillary thyroid carcinoma associated with lymphocytic thyroiditis, possibility of Warthin like PTC.
UN ESTUDIO DE HISTORIA Y ANTROPOLOGÍA MÉDICA DEL BOCIO ENDEMICO EN LA NUEVA GRANADA, A PROPÓSITO DE SU REPRESENTACIÓN ARTÍSTICA EN TIEMPOS PREHISPÁNICOS Y EN EL SIGLO XIX
Authors: Sotomayor Tribín Hugo A. , Pérez Mayorga Maritza
Published: August 2024

Con base en una clasificación de la historia epidemiológica de lo que hoy es Colombia, de revisar algunas evidencias arqueológicas prehispánicas, informes históricos del Nuevo Reino de Granada y unos registros iconográficos del siglo XIX sobre el bocio endémico, se concluye que fue la grave alteración del delicado equilibrio nutricional de las sociedades indígenas tras su contacto y destrucción con los europeos y mestizos, la causa principal para que el bocio se convirtiera en un serio problema a partir del dominio español. El hambre, la ruptura de las redes de intercambio prehispánico y la persecución del chamanismo fueron algunas de las razones por las que el bocio se tornó en un serio problema de salud pública.En un total de 12 fotografías, se presentan por primera vez juntas nueve representaciones artísticas de bocio en 2 cerámicas prehispánicas Tumaco - La Tolita, 6 pinturas y 1 dibujo del siglo XIX.
The importance of selected units of the public finances sector in the Polish legal order in the context of the right to protection of health - analysis of selected issues
Authors: Namieciński Bartosz , Trzeszczoń Dominika
Published: August 2024

The right to health care is one of the fundamental human rights and due to its nature is vested in every man. This subject matter is especially important in the Republic of Poland as it is touches an important sphere of public units’ activity. Public funds and units of the public finances sector are both involved in the implementation of the right to health care. A health care activity may take different forms, not limited solely to the area of public life. Nevertheless, public entities play a leading role in this regards: independent public healthcare establishments and public sector units are the most important entities that operate a health care activity in Poland. This is why it needs to be recognized that the right to health care and the protection of public finances are closely interrelated. As a consequence, finances spent on health care must be allocated in an ear-marked and economical fashion as it has an impact on the stability of public finances. Relevant regulations correlate with social interest so understood and with constitutional values. This study employs mostly the method of investigation of the law in force and an analytical research method. The analysis covered legislative acts and judicial decisions. The authors also review relevant opinions of legal scholars and commentators with a particular focus on the commentary from Polish financial law writers. The aim of the conducted research is to identify the constitutional foundations of healthcare system funding in Poland. In pursuing this goal, the authors also verify financial and systemic solutions related to the constitutional right to healthcare.
Categorical analysis of logic in conceptual modeling of subject areas for semantic integrity of information resources
Authors: Antonov V.V. ,   Ufa University of Science and Technology, Kononov N.A. , Palchevsky E.V. ,   Ufa University of Science and Technology,   Finance University under the Government of the Russian Federation
Published: August 2024

The article explores the potential use of categorical logic analysis to create a conceptual model of the subject area for designing an information system. The issue of semantic disunity of information resources is addressed, emphasizing its relevance due to the rapid development of information technologies and the need for their integration. Semantic disunity is identified as occurring during the integration of heterogeneous information resources, which is "embedded" at the design stage of information systems within the given subject area. The impact of an information system with violations of semantic integrity on the business processes it supports is examined, identifying problems such as information gaps, duplication, and the need for preliminary information processing. It is demonstrated that while integrating information resources is essential, it is not sufficient alone for achieving semantic integrity. The necessity of forming a single context for the integrated system components as a prerequisite for their integration is proposed. A classification of approaches to information resource integration based on semantic integrity is developed. Suggestions for applying categorical logic analysis within the framework of conceptual modeling of the subject area are presented as a universal component for ensuring the system's semantic integrity. The novelty of the proposed approach lies in considering the information system components as sets based on category theory, building categorical relations between them, and identifying structural isomorphisms in the formal model.
Automatic exploit assessment based on deep learning methods
Authors: Busko N.A. ,   Saint Petersburg Electrotechnical University ", Fedorchenko E.V. , Kotenko I.V. ,   LETI",   St. Petersburg Federal Research Center of the Russian Academy of Sciences,   St. Petersburg Federal Research Center of the Russian Academy of Sciences
Published: August 2024

Assessing and prioritizing programs that exploit software vulnerabilities and are used to carry out cyberattacks on a computer system (exploits) is crucial for effectively responding to cyberattacks. This paper presents a method for au-tomatically assessing exploits, where a model is trained to classify exploits using deep learning methods during the de-sign stage, and the trained model is used to derive an assessment of the exploit's criticality during the operation stage. The methodology is based on the hypothesis that the complexity of using an exploit, its consequences, and its assess-ment depend on the vulnerability being exploited and the source code of the exploit. This proposed methodology dif-fers from existing ones by using the CodeBERT model to classify exploits based on a marked set of exploit source codes and by marking exploit source codes according to the assessments of associated vulnerabilities using the CVSS (Common Vulnerability Scoring System) version 2.0 vulnerability assessment system. For the experimental evaluation of the developed methodology, data sources (Exploits-DB exploit database and NVD vulnerability database) and ini-tial data for experiments were identified, statistical analysis was performed, and an experimental assessment of the accuracy of exploit classification was carried out. The results obtained can be used in designing automatic exploit assessment systems as part of measures to monitor and improve the security of information systems.
Új szempont a magyar felsőoktatási intézmények teljesítményének mérésében – az egyetemek online láthatósága
Authors: Horváth Zsófia , Neszveda Gábor
Published: August 2024

In recent years, the role of the online presence of higher education institutions has greatly increased, since a huge part of their target audience is an active user of various web interfaces. As a result, measuring online institutional performance has become increasingly popular in the international literature and in higher education rankings as well. The purpose of this paper is to comprehensively describe the performance of the online platforms of Hungarian higher education institutions and to present a system of criteria for measuring institutional performance based on international literature. We analysed the traffic and backlinks of university websites, as well as their performance on social media platforms. Based on the data from 10 indicators, we created an index capturing overall online performance and a positioning index using principal component analysis. Our results show that there is a strong correlation between the indicators capturing online performance and traditional university rankings. Furthermore, we found that institutions with a higher number of students perform orders of magnitude better according to the measured indicators, suggesting their strong size dependence.
A népességöregedés kihívásai és újraelosztás a nyugdíjrendszerben
Authors: Simonovits András
Published: August 2024

The fast ageing of the population calls into question the sustainability of the Hungarian pension system. It is plausible that in addition to raising the contribution rate and the normal retirement age, the replacement ratio, especially of the high benefits, should be reduced. The adjustment is difficult because this would reinforce degressivity, while the real value pensions already set is downwards inelastic.
Pénzügyi képességek és a mélyszegény, szegregált roma családok pénzügyi helyzete
Authors: Kosztopulosz Andreász , Méreiné Berki Boglárka , Málovics György
Published: August 2024

Financial inclusion is often seen by policy makers as a tool for social inclusion, while financial literacy is seen as an important tool to support financial inclusion. Along this logic, financial inclusion and the well-being of spatially segregated, stigmatised and extremely poor groups of society can be supported through the development of financial literacy. In our study, we explore the validity of this chain of logic, building on a long-term collaborative process, based on semi-structured in-depth individual interviews and qualitative observations. Our conclusion is that the above chain of logic (financial literacy → financial inclusion → well-being) reflects a middle-class perspective and as such is rather provincial, as there are a number of subsistence strategies in the communities concerned that cannot be measured and interpreted by conventional approaches to financial literacy. Thus, in order to effectively promote the social inclusion of those concerned, one should focus on the specific social conversion factors, as emphasised by the concept of financial capability, related to segregation, poverty and stigmatisation.
Understanding the inertial forces impeding dynamic cybersecurity learning capabilities
Authors: Nyakasoka Lawrence , Naidoo Rennie
Published: August 2024

Healthcare firms need to develop cybersecurity learning mechanisms to respond faster and more proactively to a rapidly changing cybersecurity threat landscape. Many healthcare firms lack the necessary cybersecurity learning capabilities to address ever-changing and unpredictable cyberthreats effectively. In this case study, we investigate the challenges faced by a major South African healthcare software services firm that offers software as a service (SaaS) solutions. We analyse the inertial forces that impede the firm’s cybersecurity learning capabilities by integrating concepts from dynamic cybersecurity learning capability (DCLC) and IS-enabled organisational learning perspectives. Furthermore, we identify strategic and operational level inertial forces through interviews with the organisation’s experts and examination of cybersecurity documents. We then present actionable recommendations for industry practitioners to overcome these inertial forces and strengthen their cybersecurity learning capabilities. Our suggested interventions include implementing proactive leadership structures, enhancing user learning capabilities, and adopting novel risk management approaches. Additionally, we propose further directions for scholars to research the impact of inertial forces on dynamic cybersecurity learning capabilities in healthcare firms.
Between media influence and pedagogy in architecture: production of meaning from Luis Barragan’s Pritzker Prize acceptance speech
Authors: Román Guerrero Andrés , Sánchez-Llorens Mara
Published: August 2024

This text proposes a methodology for teaching and learning the history of architecture, based on the temporal influence of certain legitimizing media as a source of interpretation of architectural languages. The resulting pedagogy is based on the immediate, the mediatic and the mediatized forms, derived from research in architectural communication that analyzes the acceptance speeches of the Pritzker Architecture Prize between 1979 and 2015 and their impact on contemporary architectural culture. It examines the architectural signs enunciated by Luis Barragán and compares them with those of other editions, crossing the information gathered with other approaches, such as that of the languages of the architectural collective imaginary in different contexts, to obtain an alternative didactic for this type of readings. The resulting non-canonical teaching methodology interweaves theories, concepts or terms that reflect the understanding of architecture at a specific time thanks to the work of certain media actors.
A Comparative Study driven by Spatial Performance and VR toward Wayfinding in Architectural Space: Healthcare Buildings as a Case Study
Authors: Okuyucu Bahar , Yazici Sevil
Published: August 2024

Healthcare buildings can be complicated to navigate, causing patients to experience stress and lose time if not adequately planned. This study aims to identify the relationship between the spatial layout in healthcare buildings and wayfinding for users, by utilizing Behavioral Sequence Analysis (BSA) and Space Syntax through Immersive Virtual Reality (iVR). The methodology is based on behavioral and spatial data and was tested by using the experimental setups in VR environments. Space syntax analysis is applied to collect spatial data. Experiments were conducted by assigning wayfinding tasks in virtual hospitals with various plan configurations. Behavioral data obtained from BSA was associated with the spatial data driven by the space syntax analysis to gain a comprehensive understanding of the participants’ wayfinding behavior. The results indicate that the semi-centralized floor plan layout with high visibility levels performs better in wayfinding while the decentralized layout with low visibility values performs worse.
Composite fabrics: Typological - exploratory study for permanent tensile structures in Ecuador
Authors: Goyes-Balladares Andrea , Betancourt-Chávez Diego , Morales-Urrutia Elizabeth , Paredes-Chicaiza Juan
Published: August 2024

Tensile structures represent a notable evolution of construction materials, from their incipient construction using fabrics made with natural fibers to fabrics developed with high-performance synthetic fibers, which show the transformation of engineering and the design of new materials. The purpose of this document is to explore the use of composite fabrics in permanent tensile structural systems in Ecuador. Exploratory descriptive research is carried out, which identifies the types of application through a systematic classification. The results obtained focus on the characteristics of the use of tensile structures, construction region and detail of the technical, mechanical and physical characteristics, from the structural element approach in tensioned systems.
Eclecticism, openness and reflection. Interior design through Spanish architecture magazines 1925-1936
Authors: Villanueva Fernández María , García-Diego Villarías Héctor
Published: August 2024

With the arrival of modernity, the architect assumed a leading role in the interior design and furniture scene. New proposals from Europe designed by international architects, began to be introduced in Spain through architectural periodicals. The national magazines echoed these contents and became the vehicles for the dissemination of the new forms. This research, based on a study of articles published in eleven Spanish architectural journals between 1925 and 1936, aims, on the one hand, to provide a global perspective on the evolution of interest in interior design in Spain in that period, on the other hand, to reflect on the role of the architect in the development and dissemination of modern interiors and furniture.
Sociocultural valuation of public space in a context of rural-urban transition. Case of Morelos Avenue, San Juan Cuautlancingo, Puebla
Authors: Guevara Romero María Lourdes , Aguila Gaspar Brenda , Flores Lucero María de Lourdes
Published: August 2024

The municipality of Cuautlancingo used to agricultural production was interfered by the insertion of new urban areas causing land use speculation resulting in the reconfiguration of public spaces such as streets and avenues. The objective is to illustrate how urban expansion, through changes in land use, has interfered with the socio-spatial valuation among the inhabitants of the neighborhood of San Juan and the new housing areas, leading to conflicts in the use, access, and appropriation of public space, exemplified by Morelos Avenue. The methodology used is of a mixed nature, using GIS for the spatial analysis of urban growth. Among the main findings, it is presented how the changes in land use in the last three decades and the appearance of new housing complexes affected the sociocultural valuation of the neighborhood of San Juan Cuautlancingo.
Measures of Prevention of Tax Evasion in the Conditions of Digitalization of Tax Administration
Authors: Dirksen Tatyana V. ,   ostgraduate Student of the Department of Legal Disciplines of the Graduate School of Public Audit of the Lomonosov
Published: August 2024

The article is concerned with the analysis of the way the digitalization influences the prevention of tax evasion. The author draws the conclusion that in the context of digital transformation in tax administration measures to prevent tax evasion in the earliest stage provide taxpayers with opportunities to accomplish tax duty at minimum expense. Thus, digitalization of tax administration leads to expansion of preventive measures against tax evasion. According to the analysis of current tax legislation author suggests amendments of tax norms to boost the efficiency of measures aimed at fostering tax compliance.
History of Origination of the Principle of Legitimate Expectations
Authors: Solovyeva Natalya A. ,   Postgraduate Student of the Department of State and Municipal Finance of the Graduate School of Public Audit of the Lomonosov
Published: August 2024

The article examines the process of forming the principle of legitimate expectations within the framework of the civil law and common law by analyzing scientific doctrine and key court decisions on the example of the Federal Republic of Germany and the United Kingdom of Great Britain and Northern Ireland. The dynamics of the content of the principle of legitimate expectations is presented, as well as an assessment of the prospects for its application in resolving tax disputes. As a result of the conducted research, the author comes to the conclusion that it is necessary to further develop and study foreign experience in implementing the principle of legitimate expectations in order to form the boundaries and criteria for its application in the tax law of the Russian Federation.
On Naming a Court Hearing Appointment Stage in the Criminal Procedure
Authors: Guseynov Ramil G. ,   Postgraduate Student of the Department of Judicial Activities and Criminal Procedure
Published: August 2024

In this paper, we consider the question of which name most correctly reflects such a stage of production in the criminal process as the appointment of a court session. The procedure of actions performed by the participants when sending the case to the court to begin proceedings after a preliminary investigation is analyzed. The features inherent in the studied stage are analyzed. A comparison is made with the designation of a similar stage (‘trial’) in the criminal procedure of the Soviet and pre-revolutionary periods. The analysis of the evolution of the studied stage in Russian law is carried out. The names of the appointment of the meeting in the other countries are considered. Conclusions are drawn about what designation should be given to the appointment of the meeting in the criminal process.
Enfoque de las tres perspectivas: hacia una nueva configuración del archivo fotográfico
Authors: Colunge Rosales Ángel Enrique
Published: August 2024

El artículo propone una nueva metodología, el enfoque de las tres perspectivas, para la clasificación de fotografías en archivos. Esta se basa en la intersección de la economía visual y la teoría de la comunicación de masas. Este enfoque entiende el archivo como un fenómeno relacional, en el que las imágenes participan en redes de significación y poder. Las tres perspectivas son el emisor y la producción, la imagen y la circulación, y la audiencia y el consumo, todas enmarcadas en un espacio/tiempo específico. La metodología se aplica al estudio de caso de la colección del proyecto TAFOS, activo entre 1986 y 1998. El enfoque permite múltiples clasificaciones según la versión del archivo, y abre nuevas vías para explorar su potencial comunicativo y expresivo. La propuesta busca fortalecer la continuidad de los archivos fotográficos como agentes vivos y descentrados de la lógica bibliotecológica, promoviendo la diversidad discursiva y resistiendo el totalitarismo que restringe su acción y enunciación.
Implementación del primer laboratorio integral para la restauración del patrimonio cinematográfico en el Perú: el rol de la Asociación Guarango Cine y Video
Authors: Rebata Delgado Sofía Magaly
Published: August 2024

Este ensayo analiza el proceso de implementación del primer laboratorio integral de restauración por parte de la Asociación Guarango Cine y Video (Guarango) en el Perú. Este hito se sustenta en una cultura de investigación, innovación, capacitación continua, y en una eficaz gestión de fondos. Destaca el compromiso de Guarango con la puesta en valor del patrimonio cinematográfico y el desarrollo de la industria nacional del cine. Se examina la situación del patrimonio cinematográfico regional, la experiencia de Guarango como organización, sus producciones de alta calidad y sus avances tecnológicos. También se detalla el proceso de restauración, el control de calidad y el equipamiento del laboratorio. El caso de Guarango representa un avance significativo para la industria cinematográfica, y resalta como un ejemplo de compromiso en la preservación del patrimonio audiovisual y el fomento del cine nacional.
Mitigation of Heat Stress in Broiler Chickens during Hot Summer Seasons Through Betaine Hydrochloride Osmoprotectant Intervention
Authors: Monika M. , Rokade J.J. , Gopi M. , Vispute M. , Sonale Nagesh , Prasad Wadajkar , Bhanja S.K.
Published: August 2024

Background: Modern poultry genotypes produce more body heat due to their greater metabolic activity accompanied with tropical environment often worsens the situation. Nutritional interventions play an important role in ameliorating the negative effects of heat stress which will be more economical and sustainable approach. Methods: In order to evaluate the role of osmolyte (betaine) as a heat ameliorating agent, an experiment was conducted in broiler chicken with gradient levels of 0, 0.5, 1.0 and 1.5 g/kg for a growing period of 42 days. Each group comprised 48 birds in six replicates of 8 each. Thermo-Humidity Index value ranged 85-87 throughout the experimental period. Production performance, immunity, gut morphometry, hemato-biochemical and stress indicators were studied. Result: Supplementation of betaine significantly improved production performance as well as breast meat yield (P less than 0.05). Supplementation (1 and 1.5 g/kg) significantly (P less than 0.01) improved both the humoral and cellular immunity. Betaine supplemented groups also depict significant (P less than 0.01) rise in hemoglobin and relative immune organ weight. Addition of betaine to basal diet significantly (P less than 0.01) increased the villus length and also lowered H:L ratio, with better ALT and AST values than the control. Villi structure was more improved in 1 g/kg dose level. The present study confirms that, supplementation of betaine at 1g/kg levels could significantly improve overall growth performance, gut morphology and welfare in heat stressed broiler chickens.
The second language learner in a pandemic context: The teachers’ challenges
Authors: MacKinnon Gregory Rodney , MacLean Tyler
Published: August 2024

English language training for Chinese children has been afforded for some time by so-called offshore schools. At the onset of the 2020 pandemic, the Chinese New Year celebrations had many foreign language teachers leaving China for holidays. Unable to return to their public school teaching posts for in-person instruction, these teachers were forced to undertake emergency remote teaching. The following mixed-method study of 25 teachers examined the factors that came to bear as they attempted to modify their pedagogy to assist their students with content learning in their second language, English. The study used a survey and standardized open-ended interviews in the collection of data. The results from the teachers revealed challenges in the categories of lifestyle, pedagogy, use of technology, and system support.
Keywords: Challenges; online learning; pandemic; second-language instruction.
The difficulties of writing the preliminary draft of a master's dissertation in French as a foreign language
Authors: Benabbes Souad , Araiche Dalel
Published: August 2024

This article addresses the problem of scientific writing among university students, particularly those specializing in French as a Foreign Language at the University of Oum El Bouaghi (Algeria), focusing on the challenges encountered when preparing the preliminary draft of a master's thesis.  The article also underlines the specific difficulties faced by these students, and highlights the crucial need for appropriate support, combining the teaching of theoretical and technical knowledge with in-depth scaffolding, to facilitate this acculturation. Using a survey and a sample of 60 participants, this study gathered data in this regard. The study considered ways of improving the scientific writing of FLE students, focusing on their relationship with scientific writing and the support they receive from their teacher-supervisors. Relevant recommendations were made based on the results of the analysis.
Keywords: Acculturation; French; master's thesis; preliminary draft; scientific writing.