bluuebunny/crossref_metadata_2025 huggingface dataset:
Plate capacitor problem as a benchmark case for verifying the finite element implementation
Authors: Liu Yiming , Abali Bilen Emek , Yang Hua , Müller Wolfgang H.
Published: December 2022

In this work, parallel plate capacitors are numerically simulated by solving weak forms within the framework of the finite element method. Two different domains are studied. We study the infinite parallel plate capacitor problem and verify the implementation by deriving analytical solutions with a single layer and multiple layers between two plates. Furthermore, we study the finite parallel plate capacitor problem and verify it by Love’s potential equation and Xiang’s capacitance equation. Moreover, the fringing effect is considered and extended to problems with multiple dielectric layers, such a solution is not possible by means of the existing analytical solutions. Besides, we realize the possibility of choosing different boundary conditions (electric potential boundary conditions and charge density boundary conditions) by changing the weak form. Finally, a transient solution that includes dielectric loss and calculates the quality factor of a capacitor is presented, which may be used in capacitor design. Convergence and consistency of results are demonstrated by comparing the results between analytical and numerical solutions and also the results from different boundary conditions.
Berücksichtigung von Komorbiditäten in der Wirksamkeitsforschung zu Depressionsbehandlungen – ein narratives Review
Authors: Trinkler Catharina , Strauß Bernhard , Gumz Antje
Published: December 2022

Hintergrund

Die Berücksichtigung psychischer Komorbiditäten in der Wirksamkeitsforschung ist aufgrund hoher Komorbiditätsraten bei Depressionen und deren Auswirkungen auf die Behandlungspraxis relevant.

Ziele

Ziel dieses Beitrags ist, die Berücksichtigung von Komorbiditäten in aktuellen Studien zur Wirksamkeit von Depressionsbehandlungen zu untersuchen und die Relevanz eines wissenschaftlichen Einbezugs für die praktische Arbeit mit Depressionen zu betonen.

Methode

In einschlägigen Datenbanken wurde nach deutsch- und englischsprachigen Metaanalysen zum Thema mit einem Veröffentlichungsdatum zwischen 2000 und 2020 gesucht. Zur Prüfung des methodischen Umgangs mit Komorbiditäten in Wirksamkeitsstudien zu Depressionsbehandlungen wurden spezifische Kriterien formuliert. Studien, deren Stichproben wegen einer primär somatischen Erkrankung behandelt wurden, wurden nicht betrachtet.

Ergebnisse

Die Auswertung des methodischen Umgangs mit psychischen Komorbiditäten ergab, dass psychische Komorbiditäten in 4 von 17 Metaanalysen ausreichend berücksichtigt wurden. Drei Studien definierten Komorbiditäten als Ausschlusskriterium, 4 Studien schlossen komorbide Stichproben ein, ohne mögliche Effekte durch Komorbiditäten statistisch zu analysieren, und 6 Studien berücksichtigten Komorbiditäten gar nicht.

Diskussion

Eine ausreichende Berücksichtigung psychischer Komorbiditäten würde die Repräsentativität der Befundlage zur Wirksamkeit von Depressionsbehandlungen steigern und auf dieser Grundlage Potenzial für Qualitätsverbesserungen von Depressionsbehandlungen bieten.
Vestibular migraine or Meniere's disease: a diagnostic dilemma
Authors: Chen Jing-Yu , Guo Zhao-Qi , Wang Jun , Liu Dan , Tian E. , Guo Jia-qi , Kong Wei-Jia , Zhang Su-Lin
Published: December 2022

Meniere’s disease (MD) represents one of the vertigo disorders characterized by triad symptoms (recurrent vertigo, fluctuating hearing loss, tinnitus or ear fullness). The diagnosis of MD relies on the accurate and detailed taking of medical history, and the differentiation between MD and vestibular migraine (VM) is of critical importance from the perspective of the treatment efficacy. VM is a highly prevalent vertigo condition and its typical symptoms (headache, vestibular symptoms, cochlear symptoms) mimic those of MD. Furthermore, the misdiagnosis in MD and VM could lead to VM patients mistakenly receiving the traumatic treatment protocol designed for MD, and sustaining unnecessary damage to the inner ear. Fortunately, thanks to the advances in examination technologies, the barriers to their differentiation are being gradually removed. These advances enhance the diagnostic accuracy of vertigo diseases, especially VM and MD. This review focused on the differentiation of VM and MD, with an attempt to synthesize existing data on the relevant battery of differentiation diagnosis (covering core symptoms, auxiliary tests [audiometry, vestibular tests, endolymphatic hydrops tests]) and longitudinal follow-up. Since the two illnesses are overlapped in all aspects, no single test is sufficiently specific on its own, however, patterns containing all or at least some features boost specificity.
“Like one part of a puzzle” — individualized aromatherapy for women with gynecological cancers in aftercare: results from a qualitative-focused mixed-methods study
Authors: Czakert Judith , Stritter Wiebke , Blakeslee Sarah B. , Grabowski Jacek P. , Sehouli Jalid , Seifert Georg
Published: December 2022

Background

Gynecological cancer(s), including breast cancer patients in aftercare and survivors, need supportive strategies to cope with symptoms that are adapted to their individual needs and circumstances. Aromatherapy has potential to be such strategy, but (qualitative) empirical research taking users’ own views into consideration about the potential and challenge of aromatherapy is lacking.

Purpose

The purpose of the study is to gain insights from individualized aromatherapy as a supportive care treatment, regarding their use and evaluation by women with gynecological cancers in aftercare.

Methods

We conducted a study with a mixed-methods design, focused on qualitative research. Five essential oil products were given to 18 participants to apply individually over a 4-week period. After the intervention, qualitative semi-structured interviews were conducted. Further, we documented and assessed symptomatic burdens of the women (MYMOP2) before and after intervention quantitatively.

Results

Aromatherapy was customized by the participants according to their needs. It showed potential for relief of symptomatic burdens — especially nausea, peripheral neuropathy, pain, and sleep. Additionally, opportunities emerged to indirectly affect symptomatic burdens. These developed out of new coping strategies (e.g., sleep routines) or by combining with existing strategies (e.g., meditation). Furthermore, aromatherapy was successfully used to promote well-being and encourage mindfulness.

Conclusion

Our findings demonstrated the potential of aromatherapy as a supportive treatment modality that can be used as a kind of toolbox. Challenges, such as individual odor aversions and intolerances, and limitations due to medication or illness should be considered in future aromatherapy research.
A self-training automatic infant-cry detector
Authors: Coro Gianpaolo , Bardelli Serena , Cuttano Armando , Scaramuzzo Rosa T. , Ciantelli Massimiliano
Published: December 2022

Infant cry is one of the first distinctive and informative life signals observed after birth. Neonatologists and automatic assistive systems can analyse infant cry to early-detect pathologies. These analyses extensively use reference expert-curated databases containing annotated infant-cry audio samples. However, these databases are not publicly accessible because of their sensitive data. Moreover, the recorded data can under-represent specific phenomena or the operational conditions required by other medical teams. Additionally, building these databases requires significant investments that few hospitals can afford. This paper describes an open-source workflow for infant-cry detection, which identifies audio segments containing high-quality infant-cry samples with no other overlapping audio events (e.g. machine noise or adult speech). It requires minimal training because it trains an LSTM-with-self-attention model on infant-cry samples automatically detected from the recorded audio through cluster analysis and HMM classification. The audio signal processing uses energy and intonation acoustic features from 100-ms segments to improve spectral robustness to noise. The workflow annotates the input audio with intervals containing infant-cry samples suited for populating a database for neonatological and early diagnosis studies. On 16 min of hospital phone-audio recordings, it reached sufficient infant-cry detection accuracy in 3 neonatal care environments (nursery—69%, sub-intensive—82%, intensive—77%) involving 20 infants subject to heterogeneous cry stimuli, and had substantial agreement with an expert’s annotation. Our workflow is a cost-effective solution, particularly suited for a sub-intensive care environment, scalable to monitor from one to many infants. It allows a hospital to build and populate an extensive high-quality infant-cry database with a minimal investment.
Design principles for advancing higher education sustainability learning through transformative research
Authors: Bernert Philip , Wanner Matthias , Fischer Nele , Barth Matthias
Published: December 2022

A growing number of transformative research practices that redefine the role of science in engaging with local–mostly urban–transformation processes have emerged in recent decades. However, while education is considered a key driver for sustainability transformations, higher education has been slow to develop and implement dedicated, appropriate and effective transformative education programmes and learning modules. In this paper, we present a framework of design principles for transformative learning modules in higher education. These principles are derived from two growing discourses: higher education sustainability learning, and transdisciplinary and transformative research—both of which are centrally anchored in the field of sustainable development and sustainability science. The principles presented provide guidance for course leaders in higher education to create learning modules aimed at enabling students to become engaged in transdisciplinary and transformative research that fosters sustainability transitions in local and urban contexts. We use the Transformative Innovation Lab (TIL)—a learning course developed and tested at two German universities—as an example of how the design principles can be applied. The module, which runs over two semesters, supports Masters students in their process of developing real-world laboratories and exploring urban sustainability transitions through collaborative experimentation with local practice partners. We discuss the factors that enable and limit the implementation of transformative learning modules and outline aspects of the novel roles adopted by lecturers in transformative teaching environments. Moreover, we highlight the need for both institutional change and transformative teaching formats that go beyond transformative research as key for driving universities to take responsibility for collaboratively fostering sustainability transitions in their local contexts.
Clinical study of acupuncture combined with medication for the elderly with Alzheimer disease
Authors: Pang Jing , Yin Hongna , Sun Zhongren , Xia Kunpeng
Published: December 2022

Objective

To observe the impact of mind-regulating acupuncture plus donepezil on the cognitive ability, mean cerebral blood flow velocity, event-related potential P300, and activities of daily living (ADL) in the aged patients with Alzheimer disease (AD).

Methods

Sixty senile AD patients were divided into a treatment group and a control group following the envelope method for random allocation, with 30 cases in each group. Based on the conventional treatment of the internal medicine, the control group received oral donepezil, and the treatment group received oral donepezil plus mind-regulating acupuncture. After 4-week treatment, the two groups were evaluated by the mini-mental state examination (MMSE), Alzheimer disease assessment scale-cognitive part (ADAS-Cog), and ADL; changes in P300 and the mean cerebral blood flow velocity were also observed.

Results

Before treatment, there were no significant differences in the scores of MMSE, ADAS-Cog, or ADL between the two groups (P>0.05). The MMSE score increased after treatment in both groups and was notably higher in the treatment group than in the control group, showing intra-group and inter-group statistical significance (P<0.05). After treatment, the ADAS-Cog and ADL scores dropped in both groups and were markedly lower in the treatment group than in the control group, also showing intra-group and inter-group statistical significance (P<0.05). Compared with the same group before treatment, the latency of P300 was shortened and the amplitude was extended in both groups, all with statistical significance (P<0.05); the latency was shorter and the amplitude was larger in the treatment group than in the control group after treatment, presenting significant between-group differences (P<0.05). The mean blood flow velocity accelerated after the intervention in both groups, and the differences were statistically significant (P<0.05); the improvement in the treatment group was more notable than that in the control group (P<0.05).

Conclusion

Mind-regulating acupuncture plus donepezil can regulate the latency and amplitude of P300, increase cerebral blood flow, and improve the learning and memory abilities of AD patients.
Randomized cross-over study investigating the tolerability and side effects of an intra-oral air-cooling device compared to ice in healthy volunteers
Authors: Blacker C. , Bejhed R. S. , Frykholm P. , Ljungman G.
Published: December 2022

Oral cryotherapy (OC) is a common preventive treatment of oral mucositis (OM) and is recommended in international guidelines. Ice and air OC have previously been shown to result in temperature reductions of 8.1–12.9 °C, and 14.5 °C, respectively, in healthy volunteers. However, no direct comparison between these two modalities has been performed. The primary aim was to investigate the tolerability and side effects of air OC using an intra-oral air-cooling (IOAC) device compared with ice OC. The secondary aim was to evaluate the temperature reduction in the mouth for the two respective methods. Cross-over study with randomization to order of treatment, in 15 healthy volunteers. We evaluated the self-reported intensity, frequency, and discomfort for 13 pre-defined side effects used in previous studies. All participants were able to complete both OC sessions, although one participant required reduced airflow in the air OC arm. The subjects reported more discomfort from being cold, having sensitive teeth, and numbness in the ice OC group, while they reported more discomfort from swallowing when subjected to air OC. No significant difference in the median temperature reduction was detected in the two modalities, except for the dorsal posterior part of the tongue where temperature reduction was larger in the ice OC group. We found that oral cooling using a new IOAC device was tolerated and seems to be safe in healthy volunteers.
A Disintegrin and Metalloproteinase 10 (ADAM10) Is Essential for Oligodendrocyte Precursor Development and Myelination in the Mouse Brain
Authors: Guo Dazhi , Huang Fei , Xue Ruijun , Ma Yuehong , Xiao Lin , Lou Huifang , Pan Shuyi
Published: December 2022

A disintegrin and metalloproteinase 10 (ADAM10) plays an essential role in the regulation of survival, proliferation, migration, and differentiation of various neural cells. Nevertheless, the role of ADAM10 in oligodendrocyte precursors (OPCs) and myelination in the central nervous system (CNS) of developing and adult mouse brains is still unknown. We generated ADAM10 conditional knockout (ADAM10 cKO) mice lacking the ADAM10 gene primarily in OPCs by crossing NG2-Cre mice with ADAM10loxp/loxpmice. We found that OPCs expressed ADAM10 in the mouse corpus callosum and the hippocampus. ADAM10 cKO mice showed significant loss of back hair and reduction in weight and length on postnatal (30 ± 2.1) day, died at (65 ± 5) days after birth, and exhibited the “anxiety and depression-like” performances. Conditional knockout of ADAM10 in OPCs resulted in a prominent increase in myelination and a decrease in the number of OPCs in the corpus callosum at P30 owing to premyelination and lack of proliferation of OPCs. Moreover, the number of proliferating OPCs and mature oligodendrocytes (OLs) also decreased with age in the corpus callosum of ADAM10 cKO mice from P30 to P60. Western blot and RT-PCR results showed that the activation of Notch-1 and its four target genes, Hes1, Hes5, Hey1, and Hey2, was inhibited in the corpus callosum tissue of ADAM10 knockout mice. In our study, we provided experimental evidence to demonstrate that ADAM10 is essential for modulating CNS myelination and OPC development by activating Notch-1 signaling in the developing and adult mouse brain.
Towards Effective Consensus Scoring in Structure-Based Virtual Screening
Authors: Nhat Phuong Do , Flower Darren R. , Chattopadhyay Subhagata , Chattopadhyay Amit K.
Published: December 2022

Virtual screening (VS) is a computational strategy that uses in silico automated protein docking inter alia to rank potential ligands, or by extension rank protein–ligand pairs, identifying potential drug candidates. Most docking methods use preferred sets of physicochemical descriptors (PCDs) to model the interactions between host and guest molecules. Thus, conventional VS is often data-specific, method-dependent and with demonstrably differing utility in identifying candidate drugs. This study proposes four universality classes of novel consensus scoring (CS) algorithms that combine docking scores, derived from ten docking programs (ADFR, DOCK, Gemdock, Ledock, PLANTS, PSOVina, QuickVina2, Smina, Autodock Vina and VinaXB), using decoys from the DUD-E repository (http://dude.docking.org/) against 29 MRSA-oriented targets to create a general VS formulation that can identify active ligands for any suitable protein target. Our results demonstrate that CS provides improved ligand–protein docking fidelity when compared to individual docking platforms. This approach requires only a small number of docking combinations and can serve as a viable and parsimonious alternative to more computationally expensive docking approaches. Predictions from our CS algorithm are compared against independent machine learning evaluations using the same docking data, complementing the CS outcomes. Our method is a reliable approach for identifying protein targets and high-affinity ligands that can be tested as high-probability candidates for drug repositioning.

Graphical Abstract
Exploring the Cross-cultural Applicability of a Brief Compassionate Mind Training: a Study Comparing Sri Lankan and UK People
Authors: Kariyawasam Lasara , Ononaiye Margarita , Irons Chris , Kirby Sarah E.
Published: December 2022

Objectives

Compassionate Mind Training (CMT) is a therapeutic approach proven to be effective for reducing distress and increasing well-being in clinical and non-clinical populations. This study aimed to explore the efficacy of a short-term, online version of the CMT on compassion, distress, and well-being in a cross-cultural, non-clinical sample of Sri Lankan and UK people.

Method

A randomized controlled trial with pre-, post-measurements, and a 2-week follow-up was conducted using CMT (n = 21 Sri Lankan, n = 73 UK) and wait-list control (n = 17 Sri Lankan, n = 54 UK) groups. The intervention effects were investigated using a series of repeated-measures ANOVAs using intention-to-treat and per-protocol analyses.

Results

The 2-week CMT was effective in increasing all aspects of compassion in both Sri Lankan and UK people. In addition, some cross-cultural similarities and differences (in the factors affecting compassion) were present in the improvements following CMT between the two countries, which were maintained at a 2-week follow-up.

Conclusion

This study provides promising evidence for the efficacy and cross-cultural applicability of CMT for reducing distress and increasing well-being.
Return to Reintegration? Towards a Circular-Economy-Inspired Management Paradigm
Authors: De Angelis Roberta , Peattie Ken
Published: December 2022

Humanity has entered the Anthropocene, a new geological epoch marked by an unprecedented human impact upon planet Earth. In this context of “planetary emergency”, questioning the effectiveness of extant management research at guiding environmentally sustainable corporate outcomes has become more relevant than ever before. Responding to the calls for management scholars to reconceive the foundations of management research, this article draws on circular economy thinking to infuse the paradigmatic assumptions of the business and natural environment research field with the logic of ecological systems and bring them back to their early systemic orientation. It also discusses which barriers and limitations can prevent the circular economy from unleashing its transformational power.
Experimental characterization of thrust production mechanisms in a magnetic nozzle ECR thruster
Authors: Boni Federico , Désangles Victor , Jarrige Julien
Published: December 2022

Direct thrust measurements have been performed on a low-power (30 W) ECR plasma thruster operated with xenon. The total thrust, the force exerted on the walls of the source (thermal thrust), and the force exerted on the permanent magnet (magnetic thrust) have been measured separately for various operating conditions (power and flowrate). The results are compared for two magnetic field topologies (with a different magnetic field gradient and divergence). The magnetic thrust dominates thermal thrust for most operating conditions, and its contribution to total thrust can be as high as 80%. A saturation of magnetic thrust with increasing power has been observed and is correlated with a decrease in thrust efficiency. A high degree of electron anisotropy can be inferred from the thrust measurements.
Admission temperature and neonatal outcomes - single-centre experience in Saudi Arabia
Authors: Fneish Ammar , Alhasoon Mohammad , Al Essa Amenah , Mahlangu Radha , Alshami Noura , Alsaif Saif , Ali Kamal
Published: December 2022

Objective:

This study aimed to investigate the association between admission hypothermia (AH), neonatal mortality and major neonatal morbidities in preterm infants <33 weeks' gestation. An additional aim of the study was to examine changes in the prevalence of admission hypothermia after the initiation of a thermoregulation quality improvement (QI) project.

Method:

This is a retrospective cohort study of preterm infants < 33 weeks' gestation born at King AbdulAziz Medical City Riyadh (KAMC-R) between January 2017 to December 2020.

Results:

Eight-hundred infants were born during the study period. Four hundred and one infants (50.1%) had an admission temperature of <36.5 °C and a further 399 (49.9%) had an admission temperature of >36.5 °C. The mortality before discharge was 15.7% in infants with AH compared to 4.8% among those with an admission temperature above 36.5 °C. This remained statistically significant after adjustments for gestational age and maternal PET status on a multivariate analysis (P = .001, OR 2.7,95%CI 1.5–4.7). The need for mechanical ventilation (P = .005) and incidence of surgical NEC (P = .030) were significantly different between the two temperature groups. Mean (SD) admission temperature increased from 36.3 °C to 36.6 °C following the thermoregulation intervention program (P <.001). Admission temperature <36 °C is associated with higher mortality in the first week (P = .001, OR 3.3,95% CI (1.7–6.6)) and increased incidence of cystic PVL (P = .04, OR 2.1, CI (1.03–4.3)).

Conclusion:

Preterm infants with AH suffered higher mortality and greater neonatal morbidities.
Higher-Order Evidence and Calibrationism
Authors: Ye Ru
Published: December 2022

The higher-order evidence debate concerns how higher-order evidence affects the rationality of our first-order beliefs. This Element has two parts. The first part (Sections 1 and 2) provides a critical overview of the literature, aiming to explain why the higher-order evidence debate is interesting and important. The second part (Sections 3 to 6) defends calibrationism, the view that we should respond to higher-order evidence by aligning our credences to our reliability degree. The author first discusses the traditional version of calibrationism and explains its main difficulties, before proposing a new version of calibrationism called 'Evidence-Discounting Calibrationism.' The Element argues that this new version is independently plausible and that it can avoid the difficulties faced by the traditional version.
COVID-19 and the Ugandan Presidential Election: Contesting Lockdown Authority in Popular Songs
Authors: Pier David G. , Mutagubya Micheal
Published: December 2022

The COVID-19 pandemic struck when Uganda was in the middle of an acrimonious campaign season, in which longstanding president Yoweri Museveni was being challenged by Bobi Wine, a reggae singer turned politician. When Museveni imposed a strict lockdown, musicians sympathetic to Wine responded with songs about COVID-19 that challenged the government’s short-term, biopolitical demarcation of the national emergency. Pier and Mutagubya interpret a selection of Ugandan COVID-19 pop songs from 2020, considering in musical-historical perspective their various strategies for re-narrating the health crisis.
Localizing the UNGPs – An Afrocentric Approach to Interpreting Pillar II
Authors: Ogunranti Akinwumi
Published: December 2022

This paper presents an alternative epistemic worldview of the corporate responsibility to respect human rights (CR2R) as a norm. It examines how an Afrocentric interpretation of the CR2R norm can contribute to a relational system where corporations promote human rights in African host communities. It uses an African norm — Ubuntu — to reframe and reinterpret Pillar II in Afrocentric terms. It argues that this reframing is important for three reasons. First, Ubuntu reframing increases the CR2R norm’s intelligibility in Africa because it clarifies and contextualizes the term ‘respect’ used in Pillar II. Second, reframing the CR2R norm through Ubuntu fills the ethical gap in the interpretation of the CR2Rnorm. Third, an Ubuntu-inspired interpretation insulates the CR2R norm from some scholars’ critique that the CR2R norm’s scope is narrow because it only encourages MNCs to avoid infringing on the human rights of others without prescribing positive obligations. This paper then examines channels through which Ubuntu can influence the CR2R norm.
Progress, challenges and opportunities in early modern gender history, c.1550–1720
Authors: Tait Clodagh
Published: December 2022

Following some of the themes of the original ‘An agenda for women's history in Ireland, 1500–1900’ and others that were not as prominent, this article considers progress since 1992 and highlights opportunities for the further development of Irish early modern women's and gender history. It considers aspects of the life cycle of women and men, especially birth, youth and marriage; the economic roles of women, especially when it came to work and property; and the importance of movement to and from Ireland in both personal biographies and wider contexts. It also reflects on some of the ways in which understandings of early modern politics and of religion and belief for the period c.1550–1720 have been transformed by consideration of the role of women. While the ‘Agenda’ noted the potential of buildings and spaces, there has been a new emphasis on ‘things’ as remnants of lives and labour, expressions of cultural norms and tools in the construction of gender, selfhood and social status. Very early on, the ‘Agenda’ strongly stated that ‘the history of women is also the history of men’, and this article also notes the green shoots of the history of masculinity in early modern Ireland.
Networking early modern Irish women
Authors: Bourke Evan
Published: December 2022

Over the last decade, network analysis has developed as an approach within digital humanities as a wider array of tools has become available to humanities scholars, and these approaches are now beginning to make an impact on the disciplines of history and English. This article presents an overview of different ways of approaching network analysis. It assesses recent projects to see how they accounted for gender in their datasets and what can be learnt about early modern women from these projects. It then looks at how projects in Ireland are engaging with network analysis, discussing the approaches used by RECIRC and introducing MACMORRIS's analysis of the Dictionary of Irish biography (D.I.B.) and the Bardic Poetry Database (B.P.D.), looking at how the latter is attempting to overcome the unconscious gender bias inherent in the D.I.B.'s selection of early modern lives from the period between 1541 and 1660. Finally, it points to some of the wider issues we as scholars face when engaging with this methodology, such as access to the required training and collaboration, arguing that while these are not unique challenges to the study of gender history in Ireland, they are important debates that can enhance scholarship in the field.
Precession-driven flows in stress-free ellipsoids
Authors: Vidal Jérémie , Cébron David
Published: December 2022

Motivated by modelling rotating turbulence in planetary fluid layers, we investigate precession-driven flows in ellipsoids subject to stress-free boundary conditions (SF-BC). The SF-BC could indeed unlock numerical constraints associated with the no-slip boundary conditions (NS-BC), but are also relevant for some astrophysical applications. Although SF-BC have been employed in the pioneering work of Lorenzani & Tilgner (J. Fluid Mech., vol. 492, 2003, pp. 363–379), they have scarcely been used due to the discovery of some specific mathematical issues associated with angular momentum conservation. We revisit the problem using asymptotic analysis in the low-viscosity regime, which is validated with numerical simulations. First, we extend the reduced model of uniform-vorticity flows in ellipsoids to account for SF-BC. We show that the long-term evolution of angular momentum is affected by viscosity in triaxial geometries, but also in axisymmetric ellipsoids when the mean rotation axis of the fluid is not the symmetry axis. In a regime relevant to planets, we analytically obtain the primary forced flow in triaxial geometries, which exhibits a second inviscid resonance. Then, we investigate the bulk instabilities existing in precessing ellipsoids. We show that using SF-BC would be useful to explore the non-viscous instabilities (e.g. Kerswell, Geophys. Astrophys. Fluid Dyn., vol. 72, 1993, pp. 107–144), which are presumably relevant for planetary applications but are often hampered in experiments or simulations with NS-BC.
Numerical study of instabilities and compressibility effects on supersonic jet over a convex wall
Authors: Wang Qing , Qu Feng , Sun Di , Bai Junqiang
Published: December 2022

The supersonic jet over a convex wall is numerically investigated using the delayed detached-eddy simulation method based on the two-equation shear-stress transport model. The current study focuses on instabilities, turbulent statistics and the influence of compressibility effects. A widely applicable data-driven modal decomposition approach, called dynamic mode decomposition is used to gain further insight into the dynamical behaviours of the flow. The results demonstrate that streamwise vortices caused by the centrifugal force play significant roles in shear layer instabilities. The spanwise modulation of the streamwise vortices induces inflection points in the flow, resulting in secondary shear layer instability. This instability, which is sustained by the side-to-side sway of the streamwise vortices to obtain energy from the mean flow, dominates the rapid growth of the shear layer and turbulent stresses in the growth region. In the self-similar region, there is not only self-similarity of velocity profiles, but also self-similarity of normalized turbulent stresses. The compressibility effect significantly inhibits the growth of the shear layer and the formation of large-scale streamwise vortices. The investigation of turbulent stresses in the self-similar region with increasing convective Mach number indicates that the compressibility effect enhances turbulence anisotropy.
REFLECTION IN SECOND-ORDER SET THEORY WITH ABUNDANT URELEMENTS BI-INTERPRETS A SUPERCOMPACT CARDINAL
Authors: HAMKINS JOEL DAVID , YAO BOKAI
Published: December 2022

After reviewing various natural bi-interpretations in urelement set theory, including second-order set theories with urelements, we explore the strength of second-order reflection in these contexts. Ultimately, we prove that second-order reflection with the abundant atom axiom is bi-interpretable and hence also equiconsistent with the existence of a supercompact cardinal. The proof relies on a reflection characterization of supercompactness, namely, a cardinal
$\kappa $
is supercompact if and only if every
$\Pi ^1_1$
sentence true in a structure M (of any size) containing
$\kappa $
in a language of size less than
$\kappa $
is also true in a substructure
$m\prec M$
of size less than
$\kappa $
with
$m\cap \kappa \in \kappa $
.
Modes of Extraction in Latin America’s Lithium Triangle: Explaining Negotiated, Unnegotiated, and Aborted Mining Projects
Authors: González Lucas I. , Snyder Richard
Published: December 2022

Mitigating climate change requires a global transition from fossil fuels to a “green economy” driven by renewable energies. This shift has fostered massive investments in mining resources, notably lithium in South America, needed to store renewable energies. These mining ventures often produce harmful externalities where lithium is located. In Argentina, a major producer, striking variation has occurred in the fortunes of lithium-mining projects. In some instances, mining companies offered concessions that mitigated environmental damage and improved local socioeconomic conditions. In others, companies made minimal concessions, and in a third set they halted projects in response to local resistance. Why do mining ventures result alternatively in negotiated, unnegotiated, or aborted extraction? The article proposes a new typology of modes of extraction together with a multilevel explanatory framework that centers on the strengths and strategies of transnational mining companies, subnational governments, and local communities in setting the terms for extracting lithium.
Embracing and denouncing the ‘Mecca uniform’ in Nigerian mass media, 1950s–1970s
Authors: Katz Sara
Published: December 2022

Nigerian Muslims have undertaken the hajj for centuries. As Nigeria approached independence in the 1950s, Muslims began to discuss and debate this practice on a national scale, through Islamic associations and political committees and in the Nigerian press. At the same time, Muslim politicians began to publicly don the ‘Mecca uniform’, the white robe (thawb) and black cord (‘iqāl) common to Saudi Arabia. While Nigerian pilgrims had worn these garments for decades, their conspicuous adoption by the political elite was novel. This sartorial link between politicians and the East was amplified by photographs and commentary circulating nationally in the press, and generated a mix of admiration and concern. Christians (and some Muslims) questioned whether a secular state ought to oversee the hajj. Within roughly a decade, politicians ceased their official use of the Mecca uniform as the press became saturated with exaggerated stories of ‘corrupt’ pilgrims engaged in smuggling and other crimes. The proliferation of other mass media, such as radio and novels, contributed to this critique. This was not the end of the Mecca uniform’s public life, however, as others – such as Yoruba women in the south-west – continued to employ it in self-fashioned public images, including obituary notices. The transformation of the Mecca uniform into an object of national discourse engaging a range of Muslims and also Christians speaks to the complex dynamics shaping Islam in modern Nigeria.
The clash of sound, image and light: inter- and intra-religious entanglements and contestations during Mawlūd celebrations in the city of Jos, Nigeria
Authors: Ibrahim Murtala
Published: December 2022

This article explores recent inter- and intra-religious entanglements and contestations between Sufi Muslims, members of the Izala and Christianity, which have emerged as a result of a new way of celebrating Mawlūd in the Nigerian city of Jos. Through the adept use of loudspeakers, Izala projects a sense of dominance over the public sphere of the city and uses this as a platform to critique the Sufis. In part as a response, and as a counter-critique of Izala, the Sufis have rejuvenated their Mawlūd celebrations as a mass public spectacle, involving the use of Christmas lights to decorate the city and the construction at the entrance to major streets of temporary wooden arches decorated with flowers, Christmas lights, wreaths and images of Shaykh Ibrahim Nyass. This article argues that the Sufis, who are at a disadvantage in the practice of organized preaching and the use of sound media, have transformed the Mawlūd celebrations into a mechanism to counterbalance Izala’s dominance of the public sphere and to reassert their presence in the city. The Sufis’ incorporation of decorative Christmas objects reveals the fluid boundaries between Christians and Muslims in Nigeria, which sometimes generate dynamics of interreligious borrowing and mutual influence. This article attempts to remap and push the boundaries of studying Islam and Christianity in Nigeria, because focusing on one religion in isolation downplays the intertwining and intersection of practices between the two religious groups.
SIN, COS, EXP AND LOG OF LIOUVILLE NUMBERS
Authors: CHALEBGWA TABOKA PRINCE , MORRIS SIDNEY A.
Published: December 2022

For any Liouville number$\alpha $, all of the following are transcendental numbers:${e}^\alpha $,$\log _{e}\alpha $,$\sin \alpha $,$\cos \alpha $,$\tan \alpha $,$\sinh \alpha $,$\cosh \alpha $,$\tanh \alpha $,$\arcsin \alpha $and the inverse functions evaluated at$\alpha $of the listed trigonometric and hyperbolic functions, noting that wherever multiple values are involved, every such value is transcendental. This remains true if ‘Liouville number’ is replaced by ‘U-number’, whereUis one of Mahler’s classes of transcendental numbers.
Mapping the space of quasisymmetric stellarators using optimized near-axis expansion
Authors: Landreman Matt
Published: December 2022

A method is demonstrated to rapidly calculate the shapes and properties of quasi-axisymmetric and quasi-helically symmetric stellarators. In this approach, optimization is applied to the equations of magnetohydrodynamic equilibrium and quasisymmetry, expanded in the small distance from the magnetic axis, as formulated by Garren & Boozer [Phys. Fluids B, vol. 3, 1991, p. 2805]. Due to the reduction of the equations by the expansion, the computational cost is significantly reduced, to times of the order of 1 cpu second, enabling wide and high-resolution scans over parameter space. In contrast to traditional stellarator optimization, here, the cost function serves to maximize the volume in which the expansion is accurate. A key term in the cost function is

$\| \boldsymbol {\nabla }\boldsymbol B \|$

, the norm of the magnetic field gradient, to maximize scale lengths in the field. Using this method, a database of

$5\times 10^5$

optimized configurations is calculated and presented. Quasisymmetric configurations are observed to exist in continuous bands, varying in the ratio of the magnetic axis length to average major radius. Several qualitatively new types of configuration are found, including quasi-helically symmetric fields in which the number of field periods is two or more than six.
Bilateral collaboration between the Greenland (Kalaallit Nunaat) and United States Research Communities – from a vision to everyday practice
Authors: Mercer Jennifer L. , Nymand Josephine , Culler Lauren E. , Lynge Rebecca , Lund Sten , Gregersen Bo , Makens Brett , Virginia Ross A. , Moore Kristian G.
Published: December 2022

Each year, hundreds of international researchers enter Greenland to conduct scientific fieldwork. Historically, they have had little interaction with local communities and scientists at Greenland research institutes. Recognising that collaboration between Greenland and the United States can yield better research, consider more diverse perspectives, articulate the benefits of research to Greenland society, and train the next generation in a collaborative framework, representatives from both countries have been engaged in a series of events to cultivate bilateral relationships. Here, we describe the process of these events (workshops, conference sessions, and public dialogues), the findings, and the outcomes that have followed. Prior to this focused engagement, United States and Greenland scientists typically pursued their research independently. Since the engagement, more researchers from both countries have successfully partnered to obtain funding for collaborative research. Furthermore, development of a bilateral collaboration network is underway. The focused approach on bilateral engagement also proved essential for maintaining research and other activities during the global pandemic. When United States researchers were prevented from entering Greenland, their Greenland partners were able to continue the fieldwork, ensuring that progress was not lost. Future international projects can build on these successes to expand collaborative and interdisciplinary research in Greenland.
OP04 Methodological Challenges Of Assessing An Evolving Technology: The Cochlear Implant For Deaf People
Authors: Nijmeijer Hugo , Groenewoud Hans , Mylanus Emmanuel , Goedegebure André , Huinck Wendy , van der Wilt Gert Jan
Published: December 2022

Introduction

When Cochlear implants (CI) were first introduced, only postlingually, profoundly hearing impaired individuals were implanted unilaterally. As experience grew, eligibility was followed by prelingual deaf children, and a second contralateral CI was being considered. Due to surgical and technological improvements, eligibility criteria for CI are now shifting, encompassing patients with more residual hearing. We aimed to explore, ex ante, whether such shift is warranted.

Methods

A dynamic, population-based Markov modeling study was conducted. Model parameters were based on available evidence, expert opinion, and calibration. The model mimics Dutch demographic development in three age categories over a period of 20 years. Impact of changing eligibility was explored in terms of number of CI recipients, costs, quality of life and cost-effectiveness from a societal perspective.

Results

If those with severe hearing loss would qualify and opt for CI similar to those with profound hearing loss, this would lead to a fourfold increase of CI recipients (from 8,815 to 35,630) over a 20 year period, resulting in an increase in costs (EUR 550 million) and QALYs (54,000), with an Incremental Cost Utility Ratio of EUR 10,771/QALY (2.5–97.5 percentiles: 1,252–23,171).

Conclusions

Results suggest that expected health gains could be such, that the investment may be considered cost-effective against the backdrop of currently prevailing criteria. However, for this, a substantial increase in operating capacity, follow-up care and rehabilitation are required. Further inquiries are needed to investigate whether such increased capacity can be achieved, to ensure equitable access to those services.
OP07 Dealing With Uncertainty In Early Health Technology Assessment: An Exploration Of Methods For Decision-Making Under Deep Uncertainty
Authors: Scholte Mirre , Marchau Vincent , Kwakkel Jan , Rovers Maroeska , Grutters Janneke
Published: December 2022

Introduction

In early stages, the consequences of innovations are often unknown or deeply uncertain. This complicates health economic modelling. The field of decision-making under deep uncertainty (DMDU) uses exploratory modelling (EM) to help decision-makers make sound decisions under conditions of deep uncertainty (i.e., when stakeholders do not know, or cannot agree on, the system model, the probability distributions to place over the inputs to these models, which consequences to consider, and their relative importance). The aim of this research was to evaluate the potential of EM for the early evaluation of health technologies.

Methods

EM and early health economic modelling (EHEM) were applied to an early evaluation of minimally invasive surgery (MIS) for acute intracerebral hemorrhage, and were compared to derive differences, merits, and drawbacks of EM.

Results

The approaches fundamentally differ in the way uncertainty is handled. Where in EHEM the focus is on the value of the technology, while accounting for the uncertainty, EM focuses on the uncertainty. EHEM aims to assess whether the innovative strategy is potentially cost-effective, often using assumptions. EM on the other hand focuses on finding robust strategies (i.e., strategies that give relatively good outcomes over a wide range of plausible futures). This was also reflected in our case study. For example, EHEM provided cost-effectiveness thresholds for MIS effectiveness, assuming fixed MIS costs. EM showed that a strategy with a population in which most patients had severe intracerebral hemorrhage was most robust, regardless of MIS effectiveness, complications, and costs.

Conclusions

EM seems most suited in the very early phases of innovation (i.e., when a problem is signaled). Here, it can explore the robustness of many potential strategies under uncertainty. When potential strategies are selected, EHEM seems useful to optimize these strategies. Yet, EM methods are complex and might only be fully effective when a policy window exists that facilitates flexible research and adoption strategies.
OP14 Involving People With A Lived Experience When Developing A Proposed Health Technology Assessment Of Pelvic Organ Prolapse Treatments
Authors: Johnson Eugenie , Pearson Fiona , Lally Joanne , Farnworth Allison
Published: December 2022

Introduction

Patient and public involvement (PPI) is an expectation when conducting a health technology assessment (HTA), but there is little guidance for those wishing to embed PPI when developing an HTA proposal. We wanted to ensure PPI was central in preparing a proposal for an HTA potentially of any intervention for pelvic organ prolapse (POP) in women.

Methods

We conducted an open process to recruit two PPI co-applicants who, after induction to the project, were jointly responsible for governance of PPI in partnership with the PPI Lead throughout project planning. We facilitated an online workshop with the PPI co-applicants and other women with a lived experience of POP to: develop our question and scope; decide interventions and outcomes for the evidence synthesis; discuss the care pathway for the economic evaluation component; and plan dissemination. The PPI co-applicants were encouraged to comment on the full proposal, while workshop attendees were invited to comment on the plain language summary. Our work adhered to United Kingdom (UK) Standards for Public Involvement. We obtained funding to facilitate PPI within the proposal and reimburse those with lived experience for their time.

Results

Involving the co-applicants and workshop participants strengthened the HTA proposal by: solidifying the rationale based on lived experience; adding interventions to our evidence synthesis not previously considered; and highlighting dissemination outlets that appealed to the public. Comments on the full proposal and plain language summary ensured the proposal was accessible. However, we were unable to discuss everything we originally planned even though researcher time spent on embedding PPI into the proposal was substantial.

Conclusions

Including PPI can be valuable for developing HTA proposals. However, research is required to explore the appropriate level of involvement at the HTA proposal stage, particularly given the large amount of researcher time and additional resource needed to incorporate meaningful PPI.