bluuebunny/crossref_metadata_2025 huggingface dataset:
A study on soil arching effect of anti-slide pile considering different pile arrangements
Authors: Shangguan Yunlong , Xue Dongsheng , Wang Gang , Li Dongxin , Bao Shuochao , Wang Wenhua
Published: July 2023

Among the methods of landslide treatment, anti-slide piles are an effective measure. The soil arching effect cannot be ignored in the design of anti-slide piles, which has a significant impact on the supporting. Based on the field investigation, this paper selects the Xinyan landslide in Yanbian area of Jilin Province and uses Flac-3D to build a numerical model to simulate its soil arching effect with different pile arrangements. The simulation results show that the pile arrangement has a significant influence on the soil arching effect. When arranging piles in parallel, the soil arches between the front and rear rows of piles are distributed parallel to each other. When arranging piles in quincunx-shape, the soil arches between the rear rows of piles are the same as when laying piles in parallel. The soil between the piles flows around once when the piles are laid out in parallel, while it flows around twice when the piles are laid out in a quincunx-shape. The latter has better support than the former.
Teacher self-efficacy: development, validity, and factorial invariance of a brief measure in Peruvian university professors
Authors: Lingán-Huamán Susana K. , Mamani-Benito Oscar , Castillo-Blanco Ronald , Cabrera-Orosco Isabel , Rodriguez-Sosa Jorge , Carranza-Esteban Renzo
Published: July 2023

Introduction

Teacher self-efficacy is understood as the set of beliefs regarding teachers’ ability to exercise their role and have a positive effect on the learning of their students. Although this concept has been widely discussed in scientific literature; however, evaluating new instruments for its measurement is still necessary. This study develops and analyzes evidence of validity, factorial invariance, and reliability of a one-dimensional scale of self-efficacy for teaching among Peruvian university professors, comprised by 10 items.

Methods

A total of 529 university professors (men: 67.9%) participated, aged between 30 and 60 years. The Workload Scale and The Social Support at Work Scale were used for to evaluate convergent validity.

Results

The results revealed a satisfactory one-dimensional structure, invariant according to sex and age, and adequate internal consistency. Finally, expected associations were found with measures of workload and social support at work.

Discussion

In conclusion, the scale developed is a valid and reliable unidimensional measure to evaluate the level of perceived self-efficacy specific to teaching in Peruvian university professors.
Subclinical hypothyroidism increases insulin resistance in normoglycemic people
Authors: Yang Wanyu , Jin Chenye , Wang Haoyu , Lai Yaxin , Li Jiashu , Shan Zhongyan
Published: July 2023

Objective

To investigate the effect of simple subclinical hypothyroidism (SCH) and type 2 diabetes mellitus (T2DM) combined with SCH on insulin resistance.

Design and methods

A total of 622 people with newly diagnosed T2DM were selected as the study subjects, and 621 normoglycemic people were selected as control subjects. According to the diagnostic criteria of thyroid diseases, the subjects were divided into a normal thyroid function group and a subclinical hypothyroidism group. Both groups received a physical examination, and blood samples were collected. The measurement indexes included FPG, FINS, OGTT2hPG, OGTT2hINS, HbA1c, TC, TG, HDL-C, LDL-C, TSH, FT3 and FT4. HOMA-IR, HOMA-β, and TFQI (thyroid feedback quantile index) were calculated.

Results

There was no significant difference in age or sex distribution between the T2DM group and the normoglycemic group (P>0.05). The prevalence of thyroid dysfunction in the T2DM group was significantly higher than that in the normoglycemic group (16.39% vs. 11.27%, P<0.05), and among the different types of thyroid dysfunction, the prevalence of SCH was the highest at 14.95% (P<0.05). There was no significant difference in BMI, waist-hip ratio, blood lipid profile, HOMA-β, and HOMA-IR values between the T2DM with subclinical hypothyroidism group (T2DM+SCH+ group) and the normal thyroid function group (T2DM+SCH- group) (P>0.05). The BMI, waist-hip ratio and HOMA-IR values of the normoglycemic group with subclinical hypothyroidism (T2DM-SCH+ group) were significantly higher than those of the normoglycemic group with normal thyroid function (T2DM-SCH- group) (P<0.05), and there were no significant differences between the T2DM+SCH- and T2DM+SCH+ groups (P>0.05). HOMA-β values were significantly higher in the T2DM-SCH+ group than in the T2DM-SCH-, T2DM+SCH- and T2DM+SCH+ groups (P<0.05). As the TFQI value increased, the body weight, waist-hip ratio, diastolic blood pressure, FPG, OGTT2hPG and HbA1c values gradually increased in the T2DM group and normoglycemic group (P<0.05). HDL-C, FINS, OGTT2hINS and HOMA-β values gradually decreased (P<0.05).

Conclusion

Subclinical hypothyroidism only increases insulin resistance in normoglycemic people. As the sensitivity of the central thyroid decreases, the risk of developing diabetes increases.
Long-term data prove useful to keep track of non-indigenous seaweed fate
Authors: Petrocelli Antonella , Wolf Marion Adelheid , Sciuto Katia , Sfriso Adriano , Rubino Fernando , Ricci Pasquale , Cecere Ester
Published: July 2023

The Mar Piccolo of Taranto (southern Italy, Mediterranean Sea), a site of the European LTER network, is a transitional water system, where a century-old intensive mussel farming activity has been carried out, together with an intense import-export business of bivalve mollusks. Previous studies showed that this basin is third for NIS seaweed introduction in the Mediterranean Sea, after the Thau Lagoon and the Venice Lagoon. The present paper deals with the results of 11-year monitoring activity on non-indigenous species (NIS) of seaweeds, which was performed in the Mar Piccolo. In the studied period (2011–2021), two different time frames (i.e., 2011–2015 and 2016–2021) were considered, since they were based on a different number of sampling sites. To investigate spatial and temporal differences in the seaweed assemblage, a multivariate analysis was performed considering the NIS and the most important native species in terms of temporal occurrence. Fourteen NIS were recorded in total in the Mar Piccolo of Taranto during this period, with variable abundances among sites and years: nine species in the first time period, and thirteen species in the second one. Caulerpa cylindracea, recorded with negligible biomass in the first period, was absent in the second-period samplings. Molecular analyses confirmed the taxonomy of three species (i.e., Grateloupia minima, Neopyropia koreana, and Polysiphonia morrowii), previously identified only through morphological features. The most abundant species was Hypnea corona, which almost doubled its biomass in the second time period compared to the first one. Three species (i.e., Caulacanthus okamurae, G. minima, and P. morrowii) increased their biomass by an order of magnitude in the second time period. No significant differences were found over years. Site 1 resulted in significant differences among the sites and different seasonal pattern occurred among the investigated sites. No significant long-term changes occurred in the seaweed assemblages, suggesting the absence of strong disturbances due to the settlement of NIS.
Sample-free automated mapping of double-season rice in China using Sentinel-1 SAR imagery
Authors: Zhang Xi , Shen Ruoque , Zhu Xiaolin , Pan Baihong , Fu Yangyang , Zheng Yi , Chen Xuebing , Peng Qiongyan , Yuan Wenping
Published: July 2023

Introduction: Timely and accurately mapping the spatial distribution of rice is of great significance for estimating crop yield, ensuring food security and freshwater resources, and studying climate change. Double-season rice is a dominant rice planting system in China, but it is challenging to map it from remote sensing data due to its complex temporal profiles that requires high-frequency observations.

Methods: We used an automated rice mapping method based on the Synthetic Aperture Radar (SAR)-based Rice Mapping Index (SPRI), that requires no samples to identify double-season rice. We used the Sentinel-1 SAR time series data to capture the growth of rice from transplanting to maturity in 2018, and calculated the SPRI of each pixel by adaptive parameters using cloud-free Sentinel-2 imagery. We extensively evaluated the methods performance at pixel and regional scales.

Results and discussion: The results showed that even without any training samples, SPRI was able to provide satisfactory classification results, with the average overall accuracy of early and late rice in the main producing provinces of 84.38% and 84.43%, respectively. The estimated area of double-season rice showed a good agreement with county-level agricultural census data. Our results showed that the SPRI method can be used to automatically map the distribution of rice with high accuracy at large scales.
Social security: can rattlesnakes reduce acute stress through social buffering?
Authors: Martin Chelsea E. , Fox Gerad A. , Putman Breanna J. , Hayes William K.
Published: July 2023

Social buffering comprises the reduction of stress an organism experiences when in the presence of a companion and has been well documented in highly social animals, such as birds and mammals. To date, it has not been reported in reptiles. Rattlesnakes are cryptically social, exhibiting kin recognition and forming subtle social networks in certain contexts. We tested for the presence of social buffering against an acute stressor in 25 wild-caught adult southern Pacific rattlesnakes (Crotalus helleri) by measuring heart rate increase during a standardized disturbance when alone, in the presence of a rope (inanimate object control), and in the presence of a same-sex companion. We further tested for a greater proclivity of social buffering in montane snakes, which overwinter communally, than in lowland snakes, which mostly overwinter alone; and for a greater proclivity in females, which often aggregate during gestation and maternally attend their offspring. Results indicated that the presence of a companion significantly reduced emotional tachycardia (change in heart rate) after disturbance compared to the other treatments. We detected no difference in social buffering proclivity between montane and lowland populations, but lowland snakes exhibited a subdued acute stress response across treatments and had a longer heart rate recovery time. No difference in emotional tachycardia existed between the sexes. This novel study can benefit our understanding of social buffering, including its expression, adaptive roles, and practical applications for captive animals.
An immune-related gene prognostic index for predicting prognosis in patients with colorectal cancer
Authors: Li Chao , Wirth Ulrich , Schardey Josefine , Ehrlich-Treuenstätt Viktor V. , Bazhin Alexandr V. , Werner Jens , Kühn Florian
Published: July 2023

Background

Colorectal cancer (CRC) is one of the most common solid malignant burdens worldwide. Cancer immunology and immunotherapy have become fundamental areas in CRC research and treatment. Currently, the method of generating Immune-Related Gene Prognostic Indices (IRGPIs) has been found to predict patient prognosis as an immune-related prognostic biomarker in a variety of tumors. However, their role in patients with CRC remains mostly unknown. Therefore, we aimed to establish an IRGPI for prognosis evaluation in CRC.

Methods

RNA-sequencing data and clinical information of CRC patients were retrieved from The Cancer Genome Atlas (TCGA) and The Gene Expression Omnibus (GEO) databases as training and validation sets, respectively. Immune-related gene data was obtained from the ImmPort and InnateDB databases. The weighted gene co-expression network analysis (WGCNA) was used to identify hub immune-related genes. An IRGPI was then constructed using Cox regression methods. Based on the median risk score of IRGPI, patients could be divided into high-risk and low-risk groups. To further investigate the immunologic differences, Gene set variation analysis (GSVA) studies were conducted. In addition, immune cell infiltration and related functional analysis were used to identify the differential immune cell subsets and related functional pathways.

Results

We identified 49 immune-related genes associated with the prognosis of CRC, 17 of which were selected for an IRGPI. The IRGPI model significantly differentiates the survival rates of CRC patients in the different groups. The IRGPI as an independent prognostic factor significantly correlates with clinico-pathological factors such as age and tumor stage. Furthermore, we developed a nomogram to improve the clinical utility of the IRGPI score. Immuno-correlation analysis in different IRGPI groups revealed distinct immune cell infiltration (CD4+ T cells resting memory) and associated pathways (macrophages, Type I IFNs responses, iDCs.), providing new insights into the tumor microenvironment. At last, drug sensitivity analysis revealed that the high-risk IRGPI group was sensitive to 11 and resistant to 15 drugs.

Conclusion

Our study established a promising immune-related risk model for predicting survival in CRC patients. This could help to better understand the correlation between immunity and the prognosis of CRC providing a new perspective for personalized treatment of CRC.
Effect of early initiation of steroid-sparing drugs in patients with bullous pemphigoid
Authors: Fenne Inger Johanne , Askildsen Oftebro Guro , Vestergaard Christian , Frølunde Anne Sofie , Bech Rikke
Published: July 2023

Introduction

Bullous pemphigoid (BP) can be treated using systemic and topical glucocorticoids and/or other immunomodulatory agents. However, the long-term use of systemic glucocorticoids causes severe adverse side effects. This study was aimed at investigating whether the early initiation of corticosteroid-sparing therapy (CST) in BP patients results in better outcomes than late or no CST.

Method

We retrospectively identified all BP patients referred to the tertiary center, of the Department of Dermatology and Venerology, Aarhus University Hospital, Denmark, from 2015 to 2021. Patients’ demographics, comorbidities, treatment, remission of BP, length of admission, relapse, and 1-year mortality were recorded. All patients who received CST were dichotomised into two groups: initiated with CST <28 or >28 days. The groups were compared using t-tests. Additionally, all patients who received CST were compared with those who received systemic glucocorticoids alone. Our cohort was compared with that of a previous study (2006–2013) performed in our department. In 2015, we revised our BP treatment guidelines to include the early initiation of CST.

Results

On comparing the group of patients initiated with CST <28 versus >28 days, we found no significant differences in the complications or mortality between the groups (p = 0.63 and p=0.79, respectively). The <28 days group had a lower rate of relapse (p < 0.05). On comparing data from this study with those from the previous study, conducted before we revised our treatment guideline, we found a reduced initial dose of prednisolone and reduced admission time in this study. No significant differences were found between patients treated with CST and those treated with systemic glucocorticoids alone.

Conclusion

The rate of complications and 1-year mortality did not differ significantly between the two subgroups in this study. The relapse rate was lower in the CST <28 days group than in the CST >28 days group. The initial dose of prednisolone and admission time were reduced in this study compared with those in the previous study performed before the implementation of a local treatment guideline recommending the early initiation of CST.
SAFARIS: a spatial analytic framework for pest forecast systems
Authors: Takeuchi Yu , Tripodi Amber , Montgomery Kellyn
Published: July 2023

Non-native pests and diseases pose a risk of economic and environmental damage to managed and natural U.S. forests and agriculture. The U.S. Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) Plant Protection and Quarantine (PPQ) protects the health of U.S. agriculture and natural resources against invasive pests and diseases through efforts to prevent the entry, establishment, and spread of non-native pests and diseases. Because each pest or disease has its own idiosyncratic characteristics, analyzing risk is highly complex. To help PPQ better respond to pest and disease threats, we developed the Spatial Analytic Framework for Advanced Risk Information Systems (SAFARIS), an integrated system designed to provide a seamless environment for producing predictive models. SAFARIS integrates pest biology information, climate and non-climate data drivers, and predictive models to provide users with readily accessible and easily customizable tools to analyze pest and disease risks. The phenology prediction models, spread forecasting models, and other climate-based analytical tools in SAFARIS help users understand which areas are suitable for establishment, when surveys would be most fruitful, and aid in other analyses that inform decision-making, operational efforts, and rapid response. Here we introduce the components of SAFARIS and provide two use cases demonstrating how pest-specific models developed with SAFARIS tools support PPQ in its mission. Although SAFARIS is designed to address the needs of PPQ, the flexible, web-based framework is publicly available, allowing any user to leverage the available data and tools to model pest and disease risks.
Loose ends in the differential diagnosis of IBS-like symptoms
Authors: Lindberg Greger , Mohammadian Ghazaleh
Published: July 2023

Two thirds of the patients we believed to have IBS in the 1970’s have since been possible to diagnose with treatable conditions like bile acid diarrhea, inflammatory bowel disease, microscopic colitis, celiac disease, disaccharide malabsorption, exocrine pancreatic insufficiency, or rare genetic variants. Despite advances in diagnostic techniques a substantial proportion of patients continue suffering from IBS-like symptoms that cannot be explained by current knowledge. Although it is likely that further research will reveal small but important subgroups of patients with treatable mechanisms for IBS-like symptoms, we propose that only two large groups remain for being addressed in the clinic: those with connective tissue disorders such as Ehlers-Danlos syndrome or hypermobility spectrum disorders and those with autism spectrum disorders. Patients with connective tissue disorders exhibit identifiable disturbances of gut motor function and possibly increased gut permeability as underlying mechanisms for IBS-like symptoms. Autism spectrum disorders pose a much more difficult problem in the clinic. Disturbances of perception combined with anxiety and excessive worry about signals from the gut can lead to an endless but futile search for something being wrong. The search can involve large numbers of care givers, no one understanding the patient’s suffering. Others may try to change their diet to lessen symptoms, only to find that almost all foods may cause worrying perceptions from the gut. Early recognition of autism spectrum disorders is essential for finding better ways to help patients with gastrointestinal and, as is often the case, extraintestinal symptoms.
Evaluation of urology trainee preferences in didactic education: a choice-based conjoint analysis
Authors: Li Yi , Spradling Kyle , Allen Isabel Elaine , Conti Simon , Hampson Lindsay A.
Published: July 2023

Purpose

Didactic lectures are a commonly used educational tool during urology residency training. Recently, there has been a rapid introduction of online, collaborative didactics as a new model for resident teaching. The aim of this study is to determine which attributes of didactics education are most preferred by contemporary urology trainees.

Methods

Urology trainees were invited to complete an online choice-based exercise assessing combinations of four attributes associated with didactics education: mode of communication, learning style, presenter credentials, and curriculum design. The survey was distributed via social media platforms and the Urology Collaborative Online Video Didactics (COViD) website. A choice-based conjoint analysis was used to identify how the trainees valued different combinations of didactic education.

Results

Seventy-three trainees completed the conjoint analysis exercise. Mode of communication was rated as significantly more important than curriculum design (relative importance 28.6% vs. 19.9%). Overall, the majority preferred online/virtual presentations to in-person presentations. Respondents preferred national experts to faculty members from their local institutions, and preferred cased based lectures to didactics style lectures. A nationally standardized curriculum was also preferred over curriculum designed by local institutions. Finally, when segmented by level of training, there was increased preference for overall favored options as PGY year increased.

Conclusion

This conjoint analysis shows clear preference by trainees for online, recorded didactics, nationally standardized with national experts, and preferably in a case-based format. Academic societies in urology and program directors should consider utilizing the shared experience of previously created collaborative online lectures in developing future didactic curriculum that can meet the needs of current trainees.
Circulating levels of inflammatory cytokines and angiogenesis-related growth factors in patients with osteoarthritis after COVID-19
Authors: Krenytska Daryna , Strubchevska Kateryna , Kozyk Marko , Vovk Tetiana , Halenova Tetiana , Kot Larysa , Raksha Nataliia , Savchuk Olexii , Falalyeyeva Tetyana , Tsyryuk Olena , Ostapchenko Liudmyla
Published: July 2023

Background

The disease COVID-19, caused by SARS-CoV-2 infection, has a systemic effect and is associated with a number of pathophysiological mechanisms that mobilize a wide range of biomolecules. Cytokines and growth factors (GFs) are critical regulators of tissue damage or repair in osteoarthritis (OA) and are being recognized as key players in the pathogenesis of COVID-19. A clear understanding of the long-term consequences of SARS-CoV-2 infection, especially in patients with concomitant chronic diseases, is limited and needs to be elucidated. The study aimed to evaluate the degree of inflammation and levels of pro-angiogenic and hypoxic factors, as well as heat shock proteins HSP60 and HSP70 in plasma, of patients with OA after recovery from COVID-19.

Methods

The research involved patients of an orthopedic specialty clinic aged 39 to 80 diagnosed with knee OA. All examined patients were divided into three groups: the Control group included conditionally healthy donors, group OA included patients with knee OA mainly stage II or III and the group of OA and COVID-19 included patients with OA who had COVID-19. The plasma levels of pro-inflammatory molecules IL-1β, IL-6, TNF-α, NF-κB, angiogenic factors VEGF, FGF-2, PDGF, hypoxic factor HIF-1α and molecular chaperones HSP60 and HSP70 were measured by enzyme-linked immunosorbent assay.

Results

The study showed that in both groups of patients, with OA and convalescent COVID-19, there was an increase in the plasma level of IL-1β and a decrease in TNF-α and NF-κB levels when compared to healthy controls. Systemic deregulation of the cytokine profile was accompanied by reduction in plasma levels of pro-angiogenic growth factors, most pronounced in cases of VEGF and PDGF. This analysis did not reveal any significant difference in the plasma level of HIF-1α. A decrease in the level of stress protein HSP60 in the blood of patients with OA, as well as those patients who have had SARS-CoV-2 infection, has been established.

Conclusion

The results suggest the potential role pro-inflammatory cytokines and angiogenesis-related growth factors in pathogenesis of both joint pathologies and long-term systemic post-COVID-19 disorders.
Gypsum endolithic phototrophs under moderate climate (Southern Sicily): their diversity and pigment composition
Authors: Němečková Kateřina , Mareš Jan , Procházková Lenka , Culka Adam , Košek Filip , Wierzchos Jacek , Nedbalová Linda , Dudák Jan , Tymlová Veronika , Žemlička Jan , Kust Andreja , Zima Jan , Nováková Eva , Jehlička Jan
Published: July 2023

In this study, we used microscopic, spectroscopic, and molecular analysis to characterize endolithic colonization in gypsum (selenites and white crystalline gypsum) from several sites in Sicily. Our results showed that the dominant microorganisms in these environments are cyanobacteria, including: Chroococcidiopsis sp., Gloeocapsopsis pleurocapsoides, Gloeocapsa compacta, and Nostoc sp., as well as orange pigmented green microalgae from the Stephanospherinia clade. Single cell and filament sequencing coupled with 16S rRNA amplicon metagenomic profiling provided new insights into the phylogenetic and taxonomic diversity of the endolithic cyanobacteria. These organisms form differently pigmented zones within the gypsum. Our metagenomic profiling also showed differences in the taxonomic composition of endoliths in different gypsum varieties. Raman spectroscopy revealed that carotenoids were the most common pigments present in the samples. Other pigments such as gloeocapsin and scytonemin were also detected in the near-surface areas, suggesting that they play a significant role in the biology of endoliths in this environment. These pigments can be used as biomarkers for basic taxonomic identification, especially in case of cyanobacteria. The findings of this study provide new insights into the diversity and distribution of phototrophic microorganisms and their pigments in gypsum in Southern Sicily. Furthemore, this study highlights the complex nature of endolithic ecosystems and the effects of gypsum varieties on these communities, providing additional information on the general bioreceptivity of these environments.
Brain structure and working memory adaptations associated with maturation and aging in mice
Authors: Clifford Kevan P. , Miles Amy E. , Prevot Thomas D. , Misquitta Keith A. , Ellegood Jacob , Lerch Jason P. , Sibille Etienne , Nikolova Yuliya S. , Banasr Mounira
Published: July 2023

Introduction

As the population skews toward older age, elucidating mechanisms underlying human brain aging becomes imperative. Structural MRI has facilitated non-invasive investigation of lifespan brain morphology changes, yet this domain remains uncharacterized in rodents despite increasing use as models of disordered human brain aging.

Methods

Young (2m, n = 10), middle-age (10m, n = 10) and old (22m, n = 9) mice were utilized for maturational (young vs. middle-age) and aging-related (middle-age vs. old mice) comparisons. Regional brain volume was averaged across hemispheres and reduced to 32 brain regions. Pairwise group differences in regional volume were tested using general linear models, with total brain volume as a covariate. Sample-wide associations between regional brain volume and Y-maze performance were assessed using logistic regression, residualized for total brain volume. Both analyses corrected for multiple comparisons. Structural covariance networks were generated using the R package “igraph.” Group differences in network centrality (degree), integration (mean distance), and segregation (transitivity, modularity) were tested across network densities (5–40%), using 5,000 (1,000 for degree) permutations with significance criteria of p < 0.05 at ≥5 consecutive density thresholds.

Results

Widespread significant maturational changes in volume occurred in 18 brain regions, including considerable loss in isocortex regions and increases in brainstem regions and white matter tracts. The aging-related comparison yielded 6 significant changes in brain volume, including further loss in isocortex regions and increases in white matter tracts. No significant volume changes were observed across either comparison for subcortical regions. Additionally, smaller volume of the anterior cingulate area (χ2 = 2.325, pBH = 0.044) and larger volume of the hippocampal formation (χ2 = −2.180, pBH = 0.044) were associated with poorer cognitive performance. Maturational network comparisons yielded significant degree changes in 9 regions, but no aging-related changes, aligning with network stabilization trends in humans. Maturational decline in modularity occurred (24–29% density), mirroring human trends of decreased segregation in young adulthood, while mean distance and transitivity remained stable.

Conclusion/Implications

These findings offer a foundational account of age effects on brain volume, structural brain networks, and working memory in mice, informing future work in facilitating translation between rodent models and human brain aging.
The differential diagnosis value of radiomics-based machine learning in Parkinson’s disease: a systematic review and meta-analysis
Authors: Bian Jiaxiang , Wang Xiaoyang , Hao Wei , Zhang Guangjian , Wang Yuting
Published: July 2023

Background

In recent years, radiomics has been increasingly utilized for the differential diagnosis of Parkinson’s disease (PD). However, the application of radiomics in PD diagnosis still lacks sufficient evidence-based support. To address this gap, we carried out a systematic review and meta-analysis to evaluate the diagnostic value of radiomics-based machine learning (ML) for PD.

Methods

We systematically searched Embase, Cochrane, PubMed, and Web of Science databases as of November 14, 2022. The radiomics quality assessment scale (RQS) was used to evaluate the quality of the included studies. The outcome measures were the c-index, which reflects the overall accuracy of the model, as well as sensitivity and specificity. During this meta-analysis, we discussed the differential diagnostic value of radiomics-based ML for Parkinson’s disease and various atypical parkinsonism syndromes (APS).

Results

Twenty-eight articles with a total of 6,057 participants were included. The mean RQS score for all included articles was 10.64, with a relative score of 29.56%. The pooled c-index, sensitivity, and specificity of radiomics for predicting PD were 0.862 (95% CI: 0.833–0.891), 0.91 (95% CI: 0.86–0.94), and 0.93 (95% CI: 0.87–0.96) in the training set, and 0.871 (95% CI: 0.853–0.890), 0.86 (95% CI: 0.81–0.89), and 0.87 (95% CI: 0.83–0.91) in the validation set, respectively. Additionally, the pooled c-index, sensitivity, and specificity of radiomics for differentiating PD from APS were 0.866 (95% CI: 0.843–0.889), 0.86 (95% CI: 0.84–0.88), and 0.80 (95% CI: 0.75–0.84) in the training set, and 0.879 (95% CI: 0.854–0.903), 0.87 (95% CI: 0.85–0.89), and 0.82 (95% CI: 0.77–0.86) in the validation set, respectively.

Conclusion

Radiomics-based ML can serve as a potential tool for PD diagnosis. Moreover, it has an excellent performance in distinguishing Parkinson’s disease from APS. The support vector machine (SVM) model exhibits excellent robustness when the number of samples is relatively abundant. However, due to the diverse implementation process of radiomics, it is expected that more large-scale, multi-class image data can be included to develop radiomics intelligent tools with broader applicability, promoting the application and development of radiomics in the diagnosis and prediction of Parkinson’s disease and related fields.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=383197, identifier ID: CRD42022383197.
A method for the estimation of a motor unit innervation zone center position evaluated with a computational sEMG model
Authors: Mechtenberg Malte , Schneider Axel
Published: July 2023

Motion predictions for limbs can be performed using commonly called Hill-based muscle models. For this type of models, a surface electromyogram (sEMG) of the muscle serves as an input signal for the activation of the muscle model. However, the Hill model needs additional information about the mechanical system state of the muscle (current length, velocity, etc.) for a reliable prediction of the muscle force generation and, hence, the prediction of the joint motion. One feature that contains potential information about the state of the muscle is the position of the center of the innervation zone. This feature can be further extracted from the sEMG. To find the center, a wavelet-based algorithm is proposed that localizes motor unit potentials in the individual channels of a single-column sEMG array and then identifies innervation point candidates. In the final step, these innervation point candidates are clustered in a density-based manner. The center of the largest cluster is the estimated center of the innervation zone. The algorithm has been tested in a simulation. For this purpose, an sEMG simulator was developed and implemented that can compute large motor units (1,000's of muscle fibers) quickly (within seconds on a standard PC).
Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathway
Authors: Lai Ruosha , Fang Qiaojun , Wu Fan , Pan Song , Haque Khujista , Sha Su-Hua
Published: July 2023

Introduction

Noise-induced calcium overload in sensory hair cells has been well documented as an early step in the pathogenesis of noise-induced hearing loss (NIHL). Alterations in cellular calcium homeostasis mediate a series of cellular events, including activation of calcium-dependent protein kinases and phosphatases. Using cell-membrane- and blood-brain-barrier-permeable calpain-1 (μ-calpain) and calpain-2 (m-calpain) inhibitor MDL-28170, we tested the involvement of calpains, a family of calcium-dependent cysteine proteases, and the potential of MDL-28170 in preventing NIHL.

Methods

CBA/J mice at the age of 12 weeks were exposed to broadband noise with a frequency spectrum from 2–20 kHz for 2 h at 101 dB sound pressure level to induce permanent hearing loss as measured by auditory brainstem response and distortion product otoacoustic emissions. Morphological damage was assessed by quantification of remaining sensory hair cells and inner hair cell synapses 2 weeks after the exposure.

Results

MDL-28170 treatment by intraperitoneal injection significantly attenuated noise-induced functional deficits and cochlear pathologies. MDL-28170 treatment also prevented noise-induced cleavage of alpha-fodrin, a substrate for calpain-1. Furthermore, MDL-28170 treatment prevented reduction of PI3K/Akt signaling after exposure to noise and upregulated p85α and p-Akt (S473) in outer hair cells.

Discussion

These results indicate that noise-induced calpain activation negatively regulates PI3K/Akt downstream signaling, and that prevention of NIHL by treatment with MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathways.
Phase relations of interneuronal activity relative to theta rhythm
Authors: Mysin Ivan
Published: July 2023

The theta rhythm plays a crucial role in synchronizing neural activity during attention and memory processes. However, the mechanisms behind the formation of neural activity during theta rhythm generation remain unknown. To address this, we propose a mathematical model that explains the distribution of interneurons in the CA1 field during the theta rhythm phase. Our model consists of a network of seven types of interneurons in the CA1 field that receive inputs from the CA3 field, entorhinal cortex, and local pyramidal neurons in the CA1 field. By adjusting the parameters of the connections in the model. We demonstrate that it is possible to replicate the experimentally observed phase relations between interneurons and the theta rhythm. Our model predicts that populations of interneurons receive unimodal excitation and inhibition with coinciding peaks, and that excitation dominates to determine the firing dynamics of interneurons.
Case Report: Endoscopic trans-cerebellar medullary fissure approach for the management of brainstem hemorrhage
Authors: Wang Xue-Jian , Zhang Longyao , Yin Yu-Hua , Wang Zhi-Feng , Zhang Yi , Sun Cheng , Cui Zhi-Ming
Published: July 2023

Objective

Brainstem hematoma (BSH) is a high-risk condition that can lead to deadly and disabling consequences if not properly managed. However, recent advances in endoscopic techniques, employed for removing supratentorial intracerebral hemorrhage have shown significant improvements in operative morbidity and mortality rates compared to other approaches. In this study, we demonstrate the utility and feasibility of the endoscopic trans-cerebellar medullary fissure approach for the management of brain stem hemorrhage in carefully selected patients.

Patients and methods

A 55-year-old man presented to the emergency department in a comatose state with respiratory distress. A CT scan revealed the presence of a brainstem hemorrhage. Given the location of the hemorrhage and the need to quickly manage the associated developmental obstructive hydrocephalus and respiratory distress, an endoscopic trans-cerebellar medullary fissure approach was chosen as the most appropriate method of treatment.

Results

Total resection was achieved, and the patient gradually improved postoperatively with no new neurological deficits. He is currently under routine follow-up and is conscious but has partial hemiplegia.

Conclusion

This approach provided direct visualization of the lesion and was minimally invasive. The endoscopic trans-cerebellar medullary fissure approach may be considered an alternative to open approaches for brainstem hemorrhage in carefully selected patients.
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Authors: Perversi Fabio , Costa Cinzia , Labate Angelo , Lattanzi Simona , Liguori Claudio , Maschio Marta , Meletti Stefano , Nobili Lino , Operto Francesca Felicia , Romigi Andrea , Russo Emilio , Di Bonaventura Carlo
Published: July 2023

Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA antagonist approved in several countries worldwide for treating different types of seizures in various epileptic conditions. However, recent data show that PER can potentially address many other conditions within epilepsy and beyond. From this perspective, this review aims to examine the new preclinical and clinical studies—especially those produced from 2017 onwards—on AMPA antagonism and PER in conditions such as mesial temporal lobe epilepsy, idiopathic and genetic generalized epilepsy, brain tumor-related epilepsy, status epilepticus, rare epileptic syndromes, stroke, sleep, epilepsy-related migraine, cognitive impairment, autism, dementia, and other neurodegenerative diseases, as well as provide suggestions on future research agenda aimed at probing the possibility of treating these conditions with PER and/or other AMPA receptor antagonists.
Intraoperative irrigation of artificial cerebrospinal fluid and temperature of irrigation fluid for chronic subdural hematoma: a systematic review and meta-analysis
Authors: Huang Yong-Wei , Li Zong-Ping , Yin Xiao-Shuang
Published: July 2023

Purpose

To systematically review the different types of irrigation fluid and the different temperatures of irrigation fluid on postoperative recurrence rates in the evacuation of chronic subdural hematoma (CSDH).

Methods

We conducted a comprehensive search of electronic databases, including PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure (CNKI), WanFang, the Chinese VIP Information (VIP), and China Biology Medicine (CBM), and reference lists of relevant studies to identify all eligible studies. Two reviewers independently screened the titles and abstracts for inclusion, and the full-text articles were assessed for eligibility based on predetermined inclusion and exclusion criteria. Data were extracted using a standardized form, and the quality of the studies was assessed using a risk of bias tool. Meta-analyses were performed using a fixed-or random-effects model, and heterogeneity was assessed using the I2 statistic. The primary endpoint was the postoperative recurrence rate.

Results

After stringent screening, a total of 11 studies were identified, including six English publications, four Chinese publications, and one Japanese publication, involving a population of 29,846 patients. Our meta-analysis provides evidence that artificial cerebrospinal fluid (ACF) could decrease the post-operative recurrence rate by 47% after the evacuation of CSDH when compared to normal saline (NS) [(odds ratio) OR 0.53, 95% confidence intervals (CI): 0.31–0.90, p = 0.02, I2 = 67%]. Besides, the irrigation fluid at body temperature could decrease the postoperative recurrence rate of CSDH by 64% when compared to room temperature (OR = 0.36, 95% CI = 0.22–0.59, p < 0.0001, I2 = 0%).

Conclusion

Our analysis revealed significant difference in the choice of irrigation fluid for CSDH surgery. Notably, we found that irrigation with fluid at body temperature demonstrated superiority over irrigation with fluid at room temperature, resulting in fewer instances of recurrence. This straightforward technique is both safe and widely available, providing an opportunity to optimize outcomes for patients with CSDH. Our findings suggest that the use of body-temperature NS or ACF of room temperature during operation should be considered a standard of procedure in CSDH surgery. Nevertheless, whether the different temperature of ACF could be considered a standard of procedure in CSDH surgery still need high-quality RCTs to further identify.

Systematic review registration

https://www.crd.york.ac.uk/prospero/; Identifier CRD42023424344.
Identification of emotions evoked by music via spatial-temporal transformer in multi-channel EEG signals
Authors: Zhou Yanan , Lian Jian
Published: July 2023

Introduction

Emotion plays a vital role in understanding activities and associations. Due to being non-invasive, many experts have employed EEG signals as a reliable technique for emotion recognition. Identifying emotions from multi-channel EEG signals is evolving into a crucial task for diagnosing emotional disorders in neuroscience. One challenge with automated emotion recognition in EEG signals is to extract and select the discriminating features to classify different emotions accurately.

Methods

In this study, we proposed a novel Transformer model for identifying emotions from multi-channel EEG signals. Note that we directly fed the raw EEG signal into the proposed Transformer, which aims at eliminating the issues caused by the local receptive fields in the convolutional neural networks. The presented deep learning model consists of two separate channels to address the spatial and temporal information in the EEG signals, respectively.

Results

In the experiments, we first collected the EEG recordings from 20 subjects during listening to music. Experimental results of the proposed approach for binary emotion classification (positive and negative) and ternary emotion classification (positive, negative, and neutral) indicated the accuracy of 97.3 and 97.1%, respectively. We conducted comparison experiments on the same dataset using the proposed method and state-of-the-art techniques. Moreover, we achieved a promising outcome in comparison with these approaches.

Discussion

Due to the performance of the proposed approach, it can be a potentially valuable instrument for human-computer interface system.
The benefits of edible mushroom polysaccharides for health and their influence on gut microbiota: a review
Authors: Zhao Qilong , Jiang Yu , Zhao Qian , Patrick Manzi Habasi , Su Li , Liu Diru , Huang Xiaodan , Long Danfeng , Tang Zhenchuang , Zhang Ying
Published: July 2023

The gut microbiome is a complex biological community that deeply affects various aspects of human health, including dietary intake, disease progression, drug metabolism, and immune system regulation. Edible mushroom polysaccharides (EMPs) are bioactive fibers derived from mushrooms that possess a range of beneficial properties, including anti-tumor, antioxidant, antiviral, hypoglycemic, and immunomodulatory effects. Studies have demonstrated that EMPs are resistant to human digestive enzymes and serve as a crucial source of energy for the gut microbiome, promoting the growth of beneficial bacteria. EMPs also positively impact human health by modulating the composition of the gut microbiome. This review discusses the extraction and purification processes of EMPs, their potential to improve health conditions by regulating the composition of the gut microbiome, and their application prospects. Furthermore, this paper provides valuable guidance and recommendations for future studies on EMPs consumption in disease management.
Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity
Authors: Calderón-Colmenero Juan , Massó Felipe , González-Pacheco Héctor , Sandoval Julio , Guerrero Carlos , Cervantes-Salazar Jorge , García-Montes José A. , Paéz Araceli , Pereira-López Gabriela I. , Zabal-Cerdeira Carlos , Sandoval Juan Pablo
Published: July 2023

Endothelial progenitor cells and circulating endothelial cells have been proposed as useful markers of severity and disease progression in certain vascular diseases, including pulmonary arterial hypertension. Our study focused on evaluating the levels of circulating endothelial progenitor cells and circulating endothelial cells in patients with congenital left-to-right shunts and pulmonary hypertension undergoing definitive repair. Endothelial progenitor cells (identified by simultaneous co-expression of CD45dim, CD34 + and KDR2 + surface antibodies) and circulating endothelial cells (identified by simultaneous co-expression of inherent antibodies CD45-, CD31+, CD146 + and CD105+) were prospectively measured in seventy-four children (including children with Down syndrome), median age six years (2.75–10), with clinically significant left-to-right shunts undergoing transcatheter or surgical repair and compared to thirty healthy controls. Endothelial progenitor cells and, particularly, circulating endothelial cells were significantly higher in children with heart disease and pulmonary arterial hypertension when compared to controls. Endothelial progenitor cells showed significant correlation with pulmonary vascular resistance index when measured both systemically (r = 0.259; p = 0.026) and in the superior vena cava (r = 0.302; p = 0.009). Children with Down syndrome showed a stronger correlation between systemic cellularity and pulmonary vascular resistance index (r = 0.829; p = 0.002). Endothelial progenitor cells were reduced along their transit through the lung, whereas circulating endothelial cells did not suffer any modification across the pulmonary circulation. In children with yet to be repaired left-to-right shunts, endothelial progenitor cells and circulating endothelial cell counts are increased compared to healthy subjects.