bluuebunny/crossref_metadata_2025 huggingface dataset:
885-P: C-Reactive Protein Predicts COVID-19 Infection Severity and Length of Hospitalization
Authors: KREIT HELEN , CHERUKURI SUNDAR V. , MANDANIA ROSHNI A. , DEOKER ABHIZITH , GUPTE AKSHAY A. , MOSSAYEBI ALI , CONCHA JEANNIE B. , JUNG HYEJIN , WAGLER AMY E. , BAJPEYI SUDIP
Published: June 2021

Chronic stress can lead to many systemic complications and low-grade systemic inflammation including increased levels of inflammatory cytokines, such as C-reactive protein (CRP). CRP is a marker of systemic inflammation and is associated with depression and perceived stress. Elevations can result in weakened immune responses, thereby increasing the risk of complications and mortality from infections. Recent evidence suggests that uncontrolled inflammatory responses associated with COVID-19 are a major determinant of disease severity.

Purpose: The purpose of the study was to determine the effects of chronic stress, measured by CRP, on the severity and the length of hospitalization in COVID-19 patients.

Methods: This retrospective study used medical records from patients admitted to the University Medical Center, El Paso, TX with COVID-19 (n=436 (272M/164F); age 57.3 ± 0.8 years; BMI 29.42 ± 0.3 Kg/m2). Chronic stress was measured by blood CRP level. Severity of COVID-19 infection was determined by the peripheral oxygen saturation (SpO2) measured during the time of hospitalization. Length of hospitalization was determined by the number of days spent in the hospital. Patients were categorized into low CRP (< 3mg/L) vs. high CRP (> 3mg/L) groups and were compared using unpaired t-test.

Results: Patients with high CRP level had greater COVID-19 severity, measured by SpO2 (Low CRP: 94.2% ± 0.4 vs. high CRP: 91.9% ± 0.4; p<0.01), and greater length of hospital stay (low CRP: 6.5 ± 1.3 days vs. high CRP 8.8 ±0.5 days; p<0.05). CRP level was also negatively associated with SpO2 (r= -0.16, p<0.001) and positively associated with the length of hospitalization (r= 0.23, p<0.0001).

Conclusion: Higher levels of CRP are associated with worsened severity and increased length of hospitalization in COVID-19 patients. CRP levels should be considered in laboratory workup for COVID-19 patients and treatment should focus on reducing inflammatory damage.

Disclosure

H. Kreit: None. S. Bajpeyi: None. S. V. Cherukuri: None. R. A. Mandania: None. A. Deoker: None. A. A. Gupte: None. A. Mossayebi: None. J. B. Concha: None. H. Jung: None. A. E. Wagler: None.
890-P: CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Promotes Adipocyte Proliferation through Transcriptional Activation of NEK8 in T2DM and Obesity
Authors: CHEN YAN
Published: June 2021

Background: Adipogenesis is a complex biological process and the main cause of obesity. CDK5 Regulatory Subunit-Associated Protein 1-like 1 (CDKAL1) serves as a susceptibility gene for obesity and type 2 diabetes (T2DM). However, whether CDKAL1 plays any functional role in adipocyte proliferation had not been well investigated.

Methods: CDKAL1 expression was manipulated using a specific shRNA or the CDKAL1-full length expressing recombinant plasmids. MTT assay was performed to determine 3T3-L1 cell growth with either overexpression or downregulation of CDKAL1. Interaction between CDKAL1 and never-in-mitosis A-related kinase 8 (NEK8) in HEK293T and 3T3-L1 cells was examined using Co-immunoprecipitation (Co-IP) and Confocal immunofluorescence staining. Western blot assay was performed to determine the protein expression of NEK8 and CDKAL1. Dual-luciferase reporter assay was used to detect the transcriptional regulation of CDKAL1 on NEK8. The in vivo role of CDKAL1 and NEK8 was explored in an in vivo mouse model of T2DM.

Results: In the present study, we found that overexpression of CDKAL1 promoted adipocyte proliferation of 3T3-L1 cells, whereas knockdown of CDKAL1 delayed 3T3-L1 proliferation. Mechanically, CDKAL1 interacted with NEK8 and transcriptionally activated its expression in adipocytes. Moreover, elevated levels of CDKAL1 and NEK8 were observed in patients with T2DM compared to the healthy subjects. Implantation of 3T3-L1 cells with CDKAL1 overexpression increased blood glucose in dietetic mice.

Conclusions: Collectively, these findings suggest that CDKAL1 functions as a positive regulator of adipocyte proliferation, providing novel experimental evidences into the link between CDKAL1 and T2DM and obesity.

Disclosure

Y. Chen: None.

Funding

Chinese Postdoctoral Science Foundation (2019M651218); Natural Science Foundation of Jilin Province (20190201031JC)
893-P: Triglyceride-Rich Remnant Lipoproteins, Insulin Resistance, and Subclinical Inflammation in Youth with Type 2 Diabetes
Authors: VILLALOBOS-PEREZ ALFREDO , ZENNO ANNA , CRAVALHO CELESTE K. , MATTA SAMANTHA , COURVILLE AMBER B. , MABUNDO LILIAN , SHARMA VANDHNA R. , DAWSON JOSHUA M. , HAYMOND MOREY W. , CHUNG STEPHANIE T.
Published: June 2021

Youth with type 2 diabetes (T2D-Y) have severe insulin resistance (IR) and increased risk for atherosclerotic cardiovascular disease (ASCVD). High levels of remnant triglyceride-rich lipoproteins (TRLp), the sum of small very low-density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) particles, may mediate this additional risk. Yet, the relationship of remnant TRLp with IR and inflammation in at-risk youth is unknown. We compared lipoprotein particles in 48 youth: 33 T2D-Y and 15 age/BMI matched peers without diabetes (age 15.5 ± 2.6 y, Tanner Stage IV-V, BMI 38.6 ± 7.4 kg/m2) and determined the relationship of remnant TRLp with IR and GlycA, a composite marker of inflammation. Fasting lipoprotein particle size and number, apolipoprotein B (apoB) and GlycA were derived from the NMR LipoProfile®. Insulin sensitivity was determined by the Matsuda index during a multi-sample 75g OGTT. T2D-Y had higher A1c (7.0 ± 1.2 vs. 5.6 ± 0.3%, P<0.01), lower Matsuda index (1.3 ± 1.0 vs. 2.5 ± 1.3, P<0.01) and higher GlycA (431 ± 73 vs. 390 ± 50 μmol/L, P=0.05). Triglyceride and low density (LDL) particles were higher in T2D-Y (ApoB: 74 ± 16 vs. 56 ± 12 mg/dL; total LDL particles: 1314 ± 298 vs. 983 ± 224 nmol/L; small LDL particles: 881 ± 348 vs. 492 ± 235 nmol/L; total TRLps: 111 ± 52 vs. 71 ± 30 nmol/L, and remnant TRLps: 97 ± 45 vs. 63 ± 29 nmol/L, all P<0.01). HDL particles were not different between groups. Matsuda index inversely correlated with GlycA (r=-0.4, P=0.01), total and remnant TRLps (both r=-0.5, P<0.01) and small LDL particles (r=-0.4, P=0.03), but not with total LDL or HDL particles. GlycA was associated with small LDLp (r=0.3, P=0.07 and remnant TRLp (all r=0.2, P=0.1) but this was not statistically significant. The high-risk profile marked by high remnant TRLps and small LDL particles in T2D-Y was associated with IR and an inflammatory marker, supporting the need for longitudinal studies to determine whether reducing TRLps and inflammation will reduce ASCVD risk.

Disclosure

A. Villalobos-perez: None. S. T. Chung: None. A. Zenno: None. C. K. Cravalho: None. S. Matta: None. A. B. Courville: None. L. Mabundo: None. V. R. Sharma: None. J. M. Dawson: None. M. W. Haymond: Advisory Panel; Self; Daiichi Sankyo, Zealand Pharma A/S, Other Relationship; Self; AstraZeneca, Stock/Shareholder; Self; Xeris Pharmaceuticals, Inc.

Funding

National Institute of Diabetes and Digestive and Kidney Diseases
906-P: Parents Experience Diabetes Distress Too: Parental Reports and Association with Quality of Life and Teen A1C
Authors: INVERSO HAILEY , MOORE HAILEY R. , MORROW TROY , JASER SARAH S. , STREISAND RANDI
Published: June 2021

Background: Diabetes distress (DD) is a negative emotional response commonly associated with type 1 diabetes (T1D). Similar to youth, parents may experience their own DD resulting from the burdens associated with supporting their child with T1D. Parental DD can have a negative impact on quality of life (QoL), and disruptive factors, such as family conflict, may exacerbate parental DD. Clinical and psychosocial outcomes associated with DD have been previously examined in teens, yet less is known about the association among parental DD, QoL, and diabetes outcomes in parents of teens experiencing DD.

Methods: 60 parent-teen dyads have enrolled thus far in the ongoing THR1VE! study, a positive psychology texting-based intervention. Teens (M age 16.2 ± 1.5, 68% female, M T1D duration 7.7 ± 3.9) were eligible if they reported experiencing moderate or higher DD. Parents (83% female; 78% married/partnered; 78% white) completed the Parents - Problem Areas in Diabetes, Revised Diabetes-Related Family Conflict, and Type 1 Diabetes and Life questionnaires at baseline. A1c data were gathered at routine diabetes clinic appointments or through at-home A1c kits. Associations among parental reports of DD, diabetes-related family conflict, parental QoL, and A1c were examined.

Results: Higher parental DD was positively associated with higher parent-reported family conflict (r= 0.54), lower parental QoL (r=0.63), and higher teen A1c (r=0.31). Higher parent-reported family conflict was also associated with lower QoL (r=0.40) and higher A1c (r= 0.35), all p <0.05.

Conclusion: Similar to prior findings for teens with DD, results suggest that for parents of distressed teens, parents’ own experience of DD is also related to psychosocial variables including family conflict and QoL. Importantly, parental DD is related to children’s glycemic control, suggesting that increased psychological support for parents with teens with DD is warranted.

Disclosure

H. Inverso: None. H. R. Moore: None. T. Morrow: None. S. S. Jaser: None. R. Streisand: None.

Funding

National Institute of Diabetes and Digestive and Kidney Diseases (R01DK121316)
91-OR: Visit-to-Visit Variability of Glycated Albumin Was Associated with the Risk of Diabetic Retinopathy in Patients with Type 2 Diabetes
Authors: ZHOU JIAN , DAI DONGJUN , SHEN YUN , LU JINGYI , WANG YUFEI , ZHU WEI , BAO YUQIAN , HU GANG
Published: June 2021

Background: The association between long-term glycemic variability and diabetic retinopathy (DR) among patients with type 2 diabetes has not been clarified yet.

Objective: The aim of this study was to investigate the association of visit-to-visit variability of hemoglobin A1c (HbA1c) and glycated albumin (GA) with the risk of DR in patients with type 2 diabetes.

Design: A prospective cohort study of 315 patients (191 males and 124 females) with at least 3 measurements of HbA1c and GA prior to baseline was performed. Different GA and HbA1c variability markers were calculated, including coefficient of variation (CV), variability independent of the mean (VIM), and the average real variability (ARV). Cox proportional hazard regression models were used to explore the association between visit-to-visit HbA1c and GA variability and the risk of DR.

Results: During a mean follow-up period of 3.42 years, 81 participants developed incident DR. Multivariate-adjusted hazard ratios (HRs) of DR across tertiles of GA-CV values were 1.00, 1.42, and 2.12 (P for trend=0.027), respectively. When we used GA-VIM and GA-ARV values as exposures, similar positive associations with the risk of DR were found. Multivariable-adjusted HRs of DR associated with each unit increase in GA-CV, GA-VIM, and GA-ARV were 1.05 (95% CI 1.02-1.09), 1.69 (95% CI 1.24-2.32), and 1.13 (95%CI 1.04-1.23), respectively. However, there was no significant association between visit-to-visit variability of HbA1c and the risk of DR after multivariate adjustment.

Conclusion: The visit-to-visit variability of GA can predict the risk of incident DR in patients with type 2 diabetes, and the prediction ability is independent of the average HbA1c levels.

Disclosure

J. Zhou: None. D. Dai: None. Y. Shen: None. J. Lu: None. Y. Wang: None. W. Zhu: None. Y. Bao: None. G. Hu: None.

Funding

National Key Research and Development Project of China (2018YFC2000802); Shanghai Municipal Education Commission (20161430); Shanghai Municipal Key Clinical Specialty
941-P: Epiallopregnanolone Sulfate Is Reduced in Gestational Diabetes Mellitus and Induces Glucose-Stimulated Insulin Secretion
Authors: FAN HEI MAN , MITCHELL ALICE , GIORGI MIRKO , JONES PETER M. , MCCANCE DAVID R. , ANDERSSON DAVID A. , BEVAN STUART , MARSCHALL HANNS-ULRICH , EBERINI IVANO , FRATERNALI FRANCA , HUNT KATHARINE F. , BOWE JAMES , WILLIAMSON CATHERINE
Published: June 2021

Introduction: Serum progesterone sulfate (P4S) concentrations increase in pregnancy and bind receptors that influence glucose homeostasis. We hypothesized that P4S modulate glucose homeostasis in pregnancy.

Methods: Serum P4S were assayed using ultra-performance liquid chromatography- tandem mass spectrometry. Samples were studied in three separate patient groups: women with GDM (n=20) and matched healthy controls (n=38); participants (average 28 weeks’ gestation) from the upper (n=93) and lower (n=94) quartiles of fasting plasma glucose in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study; 11-13 week pregnant women with BMI≤25 or BMI≥35 who subsequently had uncomplicated pregnancies or developed GDM (n=50/group). Glucose-stimulated insulin secretion (GSIS) was quantified in isolated wild-type, Fxr-/- and Tgr5-/- mouse and human islets in the presence of P4S and TRPM3 inhibitor isosakuranetin (ISO). Intracellular calcium concentrations were measured after treatment with P4S in TRPM3 transfected HEK293. Computer modelling using Molecular Operating Environment generated 3D structures of TRPM3 and P4S binding.

Results: Epiallopregnanolone sulfate (PM5S) concentrations were reduced in serum samples from the HAPO study participants with higher fasting plasma glucose (p<0.01), in women with GDM (p<0.05) and in early pregnancy samples from women with BMI ≥35 who subsequently developed GDM (P<0.05). In wild-type and human islets, 50μM PM5S increased GSIS by at least 2-fold at 20mM glucose concentrations (P<0.001). This effect was not abolished from islets obtained from Fxr-/- or Tgr-/- mice, however it was abolished by ISO. PM5S elicited Ca2+ influx in TRPM3-expressing HEK293 cells. Computer modelling and docking showed identical positioning of PM5S to cholesterol hemisuccinate in TRPM3.

Conclusion: PM5S increases GSIS and concentrations are reduced in the serum of women with GDM. The increased GSIS is mediated by TRPM3.

Disclosure

H. Fan: None. F. Fraternali: None. K. F. Hunt: None. J. Bowe: None. C. Williamson: Consultant; Self; GlaxoSmithKline plc., Mirum Pharmaceuticals. A. Mitchell: None. M. Giorgi: None. P. M. Jones: None. D. R. Mccance: None. D. A. Andersson: None. S. Bevan: None. H. Marschall: None. I. Eberini: None.

Funding

Tommy’s; Guy’s and St Thomas’ Biomedical Research Centre; National Health Service
943-P: Glycated Albumin as a Predictor of Adverse Neonatal Events in Pregnant Women with Diabetes
Authors: POWERS CARSON JENNIFER L. , CARTER EBONY B.
Published: June 2021

Control of plasma glucose is effective to reduce adverse neonatal events (ANE) for pregnant women with diabetes, including gestational diabetes (GDM); however, compliance can be poor. We examined the utility of glycated serum protein (GSP) and glycated albumin (%GA) to predict risk of ANE. Published studies have shown greater risk if %GA of ≥ 12 -15.8%, but population and trimester-specific cut-offs are needed. Additionally, BMI has been reported to affect %GA. We prospectively recruited pregnant women with type 2 diabetes or GDM and collected serum during the second and/or third trimesters. No exclusion criteria were used, but an attempt was made to recruit similar numbers of overweight and Class I, II, or III obese BMI. Enrolled subjects included 52% African-American and 41% Caucasian with median BMI 34.0 (25.0 - 70.4). Thirty bio-banked samples, matched for ethnicity, BMI and gestational age, from women with no evidence of diabetes were used as controls. GSP and %GA as well as various lipid markers were measured using methods from Roche or Diazyme (GSP, %GA) on automated analyzers. Our goals were to determine preliminary cut-off values for GSP and %GA to predict ANE and identify whether additional lipid markers may improve prediction. Of those delivered to date (n=55), two controls and four subjects experienced one or more ANE (macrosomia, hyperbilirubinemia, hypoglycemia or RSD). Using receiver operator curve analysis, trimester two values of %GA or GSP were much better at predicting ANE (AUC: 0.896, 0.910, respectively) than trimester three values (AUC: 0.662, 0.713, respectively). Our data suggests that a cut-off ≥ 11.8 %GA can effectively predict those at greatest risk in this population. Statistical analysis showed no differences in %GA or GSP between ethnicities or BMI subgroups. Additional data is needed to determine whether or not incorporation of lipid markers will improve risk prediction. However, only beta-hydroxybutyrate shows significant differences between subjects and controls.

Disclosure

J. L. Powers carson: None. E. B. Carter: None.

Funding

American Diabetes Association/Pathway to Stop Diabetes (1-19-ACE-02 to E.B.C.); National Institutes of Health (P30DK020579)
96-OR: Parameters of Glycemic Variability as Predictors of LGA in Pregnant Women with Well-Controlled Type 1 Diabetes (T1D)
Authors: SIBIAK RAFAL , MRZEWKA-ROGACZ BEATA , MANTAJ URSZULA , GUTAJ PAWEL , WENDER-OZEGOWSKA EWA
Published: June 2021

Background: According to the current recommendations, pregnant patients with T1D are encouraged to use continuous glucose monitoring (CGM) systems. The use of CGM reduces the risk of LGA births and neonatal hypoglycemia. This study aimed to assess the influence of the parameters of glycemic variability on the risk of LGA births.

Methods: The study cohort included 75 patients with T1D who were using CGM systems throughout pregnancy. The study population we divided into two subgroups: mothers of LGA and non-LGA newborns. We defined LGA as a birth weight above the 90th percentile. Calculated birthweight percentiles we adjusted for maternal weight, height, parity, and ethnicity, as well as the infant’s sex and gestational age. For each trimester separately and for the whole pregnancy, we calculated indicators of glucose variability, such as time spent in and above the target range (TIR, TAR). We also calculated the %CV, MODD, MAGE, GRADE, %GRADE hypo, %GRADE hyper, CONGA (1, 2h), LBGI, and HBGI.

Results: The mean values of glycated haemoglobin in both groups met the criteria of well-controlled T1D in each trimester of pregnancy. Nevertheless, there were 25/75 infants with LGA. Only the 1st-trimester maternal HbA1c values were significantly higher in the group of LGA infants. However, in the LGA-mothers, mean glucose levels and TAR values were significantly increased in each trimester. Bivariate logistic regression revealed that the LGA risk was positively associated with %GRADE hyper, MODD, MAGE, and TAR, and negatively associated with LBGI, %GRADE hypo, and TIR. After the adjustments for the maternal age, pregestational BMI, gestational weight gain, and HbA1c values, only the relationships with the first trimester’s %GRADE hypo and %GRADE hyper as well as %GRADE hypo calculated for whole pregnancy remained significant.

Conclusion: The parameters of glucose variability rather than HbA1c may help predict LGA infants, especially in patients with well-controlled diabetes.

Disclosure

R. Sibiak: None. B. Mrzewka-rogacz: None. U. Mantaj: None. P. Gutaj: None. E. Wender-ozegowska: Advisory Panel; Self; Novo Nordisk, Board Member; Self; Medtronic, Other Relationship; Self; Medtronic, Novo Nordisk.
97-LB: Bringing Simulation Technologies to People with T1D: A Pilot Study
Authors: COLMEGNA PATRICIO , BISIO ALESSANDRO , MCFADDEN RYAN , WAKEMAN CHRISTIAN A. , OLIVERI MARY C. , NASS RALF , BRETON MARC D.
Published: June 2021

Background: Researchers have extensively used metabolic simulators as a fast, inexpensive, and safe way of testing novel treatment strategies. This work aims to bring this technology to people with T1D to enable unique patient/data interactions.

Methods: A 5-week pilot study was carried out in 15 adults with T1D using Control-IQ technology (age 36±13 years, HbA1c 6.5±0.7%) to evaluate acceptance of the proposed Web-Based Simulation Tool (WST). The study consisted of 1 week of observation (Phase 1) and 4 weeks of interaction with WST (Phase 2). Data were automatically collected via Tandem Diabetes Care t:connect web application, and used to generate personalized models of the participants’ glucose metabolism.

Results: Success rate in generating models was 86.4%, achieving an average MARD of 7.4±3.2%. Interaction time was 15.8±10.7 min per week. Comparing Phases 1 and 2, no variation was detected in time in range 70-180 mg/dl (80.1 [70.4,89.6]% vs. 80 [69.7,87.9]%). Time in 70-250 mg/dl increased slightly (94.2 [90.3,95.7]% vs. 96.2 [92.1,97.9]%), especially overnight (92.8 [88.3,98.2]% vs. 97.2 [91.8,99.6]%), and for participants who modified their pump settings based on WST simulations (90 [88.7,92.4]% vs. 94.5 [87.1,99.6]%). One subject tested COVID positive during the study and was excluded from this analysis due to abnormal hyperglycemia.

Analysis of Diabetes Distress Scale (DDS)-17 pre and post-system use shows a reduction in diabetes-related distress (2.2 [1.7,3.4] vs. 2 [1.7,2.4]). Trust, ease of use, and usefulness scores were 80 [60,80]%, 60 [60,80]%, and 80 [60,80]%, respectively. During the follow up interviews, 10 participants reported they enjoyed using WST and would implement it into their diabetes management; 2 did not like the system but see the potential of it for other people; 3 participants did not like the system at all.

Conclusions: Evidence from this study suggests that simulation technologies may empower people with T1D, making them more confident in their diabetes self-management.

Disclosure

P. Colmegna: None. A. Bisio: None. R. Mcfadden: None. C. A. Wakeman: Stock/Shareholder; Self; Dexcom, Inc., Tandem Diabetes Care. M. C. Oliveri: None. R. Nass: None. M. D. Breton: Consultant; Self; ADOCIA, Dexcom, Inc., Research Support; Self; Arecor, Dexcom, Inc., Novo Nordisk A/S, Tandem Diabetes Care, Speaker’s Bureau; Self; Arecor, Tandem Diabetes Care, Stock/Shareholder; Self; Dexcom, Inc., Insulet Corporation, Tandem Diabetes Care.

Funding

JDRF (2-APF-2019-737-A-N)
994-P: Prevalence and Persistence of Post-diagnosis Hyperglycemia in Cancer Patients
Authors: VISKOCHIL RICHARD , PAULECK SVENJA , WINN MACI , FUNAI KATSU , LITCHMAN MICHELLE L. , AKERLEY WALLACE , COLMAN HOWARD , ULRICH CORNELIA M. , PLAYDON MARY C. , HARDIKAR SHEETAL
Published: June 2021

Introduction: Cancer patients are more likely to develop hyperglycemia (HG) compared to cancer-free adults, and this increased risk is highest in the year following cancer diagnosis. The persistence of post-diagnosis HG and degree of glycemic control in this population is unclear.

Methods: This study utilized data from n=9,588 cancer patients from the Huntsman Cancer Institute, UT. Clinicodemographic characteristics, biomarkers, and cancer diagnoses were extracted from electronic medical records (EMR) and tumor registry. Patients with a new HG diagnosis (ICD) of any kind between 30 days and 1 year after cancer diagnosis were included. Persistence of HG was determined through elevated Hemoglobin A1c (HbA1c) and/or new anti-HG medication prescription. Patients who did not survive >1 year after cancer diagnosis or were diagnosed with cancer <1 year prior to EMR abstraction were excluded.

Results: Of the 2,964 (30.9%) cancer patients with a HG diagnosis after cancer, 26.2% (n=777) were diagnosed with HG between 30 days and 1 year after cancer diagnosis, of these n=357 met criteria for HG evaluation. Data on HbA1c and/or anti-HG medication >1 but <2 years post-cancer diagnosis was available for 109 patients. Of these, 60 (55.0%) received a new anti-HG medication prescription and an additional 30 (27.5%) had an HbA1c greater than 5.7%, indicative of HG. Interestingly, body mass index (BMI) was similar among those that did and did not receive anti-HG medication (32.0 ± 6.4 vs. 32.6 ± 7.8 kg/m2, respectively), suggesting an alternate mechanism for lack of glycemic control.

Discussion: Taken together, 82.5% of patients diagnosed with HG in the year following a cancer diagnosis still presented with HG between one and two years post-cancer diagnosis, and there was no difference by BMI among those that did and did not receive anti-HG medications. This suggests that HG post-cancer diagnosis is not a transient effect of cancer therapy (e.g., corticosteroids), and may have long-term health implications in cancer survivors.

Disclosure

R. Viskochil: None. S. Hardikar: None. S. Pauleck: None. M. Winn: None. K. Funai: None. M. L. Litchman: Research Support; Self; Abbott Diabetes. W. Akerley: None. H. Colman: Advisory Panel; Self; Adastra Pharmaceuticals, Orbus Therapeutics, Consultant; Self; Best Doctors/Teladoc. C. M. Ulrich: None. M. C. Playdon: None.

Funding

University of Utah Health/Larry H. Miller Family Wellness Initiative
Análise bibliométrica da produção científica internacional sobre people analytics
Authors: Silva Artur Leonardo Imamura Ferreira da , Oliva Eduardo de Camargo , Kubo Edson Keyso de Miranda
Published: June 2021

O people analytics é uma prática de recursos humanos (RH), possibilitada pela tecnologia da informação, que utiliza análises estatísticas de dados relacionados a processos de RH, criando recortes sobre a situação atual e prevendo situações futuras. O objetivo desta pesquisa baseou-se no mapeamento das características da produção científica internacional sobre people analytics, a partir de uma amostra de 50 artigos e reviews extraídos base de dados Scopus, sobre as quais foram realizadas análises bibliométricas. Os resultados indicam que (I) a pesquisa sobre people analytics está em estágio inicial e passa por um momento de crescimento, dessa forma, abrem oportunidades de novas correntes de pesquisa; (II) aparentemente não existe predominância exponencial de produção de artigos e reviews de autores, instituições e periódicos prolíficos sobre a temática; (III) as abordagens proeminentes são os aspectos de conceito de people analytics, desenvolvimento operacional e estratégico, o processo de people analytics, a potencialidade e agregação de valor do people analytics, modelos de people analytics. Este estudo contribuiu para evidenciar de forma mais robusta, alargada e atualizada a produção científica do tema people analytics, divulgada na literatura acadêmica internacional, contribuindo para o realce e fomento do conhecimento sobre o citado tema.
MATERIAL AND PROCEDURAL ASPECTS OF PROTECTING THE RIGHTS OF PARTICIPANTS IN TRANSPORT OBLIGATIONS
Authors: TUZHILOVA-ORDANSKAYA E.M. , MURATOVA A.R.
Published: June 2021

This study is determined by the theoretical and practical interest in the study of issues related to the protection of the rights of participants in transport obligations. The need for research is dictated by the direct needs of the subjects of the relevant legal relations in the actual exercise of rights, as well as in connection with the search for the most effective use of existing civil law forms of protection of violated rights of participants in transport obligations. Turning to general theoretical problems, in particular, to the concept of protection of rights, it is concluded that this is common to civil law and civil procedure. The authors state that the specifics of transport obligations determine the specifics of protecting the rights of their participants, where the main role is given to the non-jurisdictional form of protection. The authors pay special attention to the claims procedure for dispute settlement, supporting the position that this procedure is inter-industry in nature. At the same time, it is proposed to use other conciliation procedures along with the claim procedure (or after) before applying to the court, which, in turn, according to the authors, will allow building an effective system for protecting the violated rights of participants in transport obligations.
CIVIL-LAW SET-OFF AND SET-OFF MADE WHEN THE COURT SATISFIES COUNTERCLAIMS AND INITIAL CLAIMS: THEORETICAL REFLECTIONS ON THE SIMILARITIES AND DIFFERENCES OF LEGAL INSTITUTIONS (continuation)
Authors: ABUSHENKO D.B.
Published: June 2021

In the article, the author continues to distinguish between the civil-legal set-off and the set-off made when the court satisfies the counterclaim and initial claims. As a criterion, recognition is taken as an act of will, coming respectively from the compensator (the person to whom the statement of set-off is addressed) and the defendant in the counterclaim. Judicial and non-judicial confessions are analyzed. With regard to judicial recognition, the conclusion is justified that, depending on the type of process and the existence of rules on mandatory professional judicial representation, it will be either ordinary evidence or a basis for exemption from proof, and in some cases also entail certain substantive consequences. Individual cases of so-called qualified recognition are considered (discrepancy in quantitative characteristics; discrepancy in relation to the subject or object of the legal relationship; recognition of another legal relationship; notification to the court of two or more facts, some of which correspond to the interests of the procedural opponent, and the other part – to the interests of the recognizer; discrepancy in the qualification of legal consequences; recognition of the fact of termination of claims with the reservation that they were subsequently restored on the basis of the realized secondary right).
THE EXECUTIVE ACTION TAKEN BY THE JUDICIAL BAILIFF-EXECUTOR OUTSIDE OF ENFORCEMENT PROCEEDINGS
Authors: SELIONOV I.V.
Published: June 2021

The article examines the enforcement action performed by the bailiff-executor in accordance with paragraph 16 of part 1 of Article 64 of the Law on Enforcement Proceedings – checking the correctness of the withholding and transfer of funds under the executive documents presented in the manner prescribed by part 1 of Article 8, part 1 of Article 8.1 and part 1 of Article 9 of the Law on Enforcement Proceedings. The purpose of the article is to identify the features of this action, to determine its place in the list of enforcement actions, and in general in enforcement proceedings. Based on the results of the study, the author comes to the conclusion that checking the correctness of withholding and transferring funds under executive documents is not an enforcement action. In this article, the author considers the specified action as an extra-executive action carried out by the bailiff-executor to control the execution by other bodies and organizations, expressed in conducting an audit in relation to the bodies directly executing the requirements of the executive document and in the event of their failure to bring them to justice. At the same time, in this article, the author considers checking the correctness of the withholding and transfer of funds under executive documents as the control authority of the bailiff, taking into account the provisions of the new Federal Law of 31 July 2020 No. 248-FZ “On State Control (Supervision) and Municipal Control in the Russian Federation”. The author makes his proposals for improving the legislation of the Russian Federation on enforcement proceedings.
THE DILEMMA OF ISLAMIC EDUCATION AND PROSTITUTION LIFE
Authors: Akbar Waza Karia , Yuhelna Yuhelna , Rahmadani Sri
Published: June 2021

The Minangkabau society is famous for the tradisional philosophy of adat basandi sarak, sarak basandi kitabullah (ABS-SBK). Education and religious values have been passed down from one generation to another. However, it is still not going well. It is seen with the many women who are trapped in negative terms. They are very weak people in the economy and religious education. The goal to be achieved in this study in find out the causes of Minangkabau women who are continually involved in the world prostitution. The focus of this research is the woman in the localization of the goddess Aro, West Sumatera. The method used by researchers is qualitative with case studies in the Andam Dewi. The findings suggest that those involved in prostitution were women aged 17-27 years old because of the economic factors and religious knowledge are very weak. Other findings also show the weak role of Mamak in Minangkabau in monitoring its ministry.
The Interaction of Possible Worlds through the Prism of Cognitive Narratology
Authors: Babelyuk Oksana , Koliasa Olena , Matsevko-Bekerska Lidiia , Matuzkova Olena , Pavlenko Nina
Published: June 2021

The article deals with the analysis of literary narrative where a possible unreal fictional world and a possible real fictional world usually coexist. When the norms of life plausibility are consciously violated, the real and the unreal possible worlds are emphatically opposed. Hence, their certain aspects are depicted in a fantastically exaggerated form. The interaction of possible worlds in a literary narrative destroys the stereotypes of the reader’s perception. It can occur in different planes: structural (a shift of plot elements of the story, transformation, unusual, sharp turns of the borrowed plot, violations of a plotline); fictional (a combination of real and fantastic features in one image); temporal (violations of the chronological flow of time, a shift of time flow); spatial (expansion or contraction of space, magical spatial formations, displacements, deformations). By their nature, the interaction of different possible worlds can be continuous, partial, and fragmentary; resulting from their boundaries may overlap or be violated (entirely or partially). The continuous interaction of different possible worlds, destruction of their borders, although they do not disappear completely, make them largely blurred, interpenetrating each other. In the case of partial interaction of possible worlds, their boundaries intersect. In the case of fragmentary interaction of possible worlds, their common points are slightly visible, for example, only the borrowed title of a literary work or a character’s name, or a fantastic concrete event or a place of the event.
Uma reflexão sobre a direita evangélica e o atentado de 11 de setembro de 2001
Authors: Souza Silas Luiz de
Published: June 2021

Este texto está inserido no esforço de memória e reflexão sobre o atentado de 11 de setembro de 2001 aos Estados Unidos da América. De forma mais específica, demonstra o pensamento dos evangélicos norte-americanos que, animados pelo conceito do destino manifesto, se representam como um luzeiro divino para o mundo e os demais como povos a serem civilizados ou destruídos, uma vez que são agentes diabólicos na terra. Sendo um povo orientado por Deus através da Bíblia, a acusação feita à nação é de ter abandonado os princípios bíblicos e, com isso, enfraquecido o País. Assim, os ataques foram entendidos como punição de Deus aos pecados nacionais por um lado e, por outro, como agressão do inimigo capitaneado pelo próprio Diabo, para impedir o destino nacional de cuidar da democracia e da civilização mundiais. Embora houvesse outras visões, essa teve maior repercussão, tendo sido defendida por grandes nomes da mídia evangélica no País. De modo geral, os evangélicos brasileiros repetiram aqui as mesmas ideias expostas na América do Norte.
Cultura, jóvenes y futbol: La “Barra” como configurador de la individualidad
Authors:   , García Solís Gabriel Amós
Published: June 2021

El presente texto trata de analizar la relación que existe entre la cultura, los jóvenes y el futbol, planteando como problema principal la forma en que los jóvenes pueden configurar una individualidad a través de la pertenencia a un grupo de animación o “barra”, esto con el objetivo de comprender de mejor manera la forma en que los referentes culturales e individualizadores se interiorizan dentro de un contexto socio histórico particular, como lo es el hipermoderno (Lipovetsky, 2006, 2007, 2010, 2016), mismo que tiende a generar cambios a velocidades nunca antes vistas y que podría malinterpretarse como un escenario caótico, efímero y vertiginoso, en donde las certezas de los estadios previos de la modernidad se desvanecen y dejan al individuo a la deriva. Cómo objetivos de investigación podemos enunciar los siguientes: como objetivo general. Dar cuenta de la configuración de la individualidad en jóvenes, al analizar el papel que juega la cultura, el ocio y el deporte. Específicos: Analizar la forma en que la individualidad se entiende a través de un breve análisis contextual de la nueva etapa de la modernidad; Comprender como la cultura del ocio y el deporte se entrelazan con el concepto de individualidad y como puede entenderse teóricamente; Analizar de qué manera influye la pertenencia a un grupo de animación de futbol en la configuración de la individualidad de los jóvenes, a través del análisis del estudio de caso aterrizado al grupo de animación “Hinchada Popular y Familiar Unión Auriazul”, del Club Universidad Nacional A.C.
Az étkezési magatartás összefüggése az ételválasztási motivációkkal és egyes személyiségbeli jellemzőkkel középiskolások körében
Authors: Szabó Katalin , Pikó Bettina
Published: June 2021

Bevezetés: Manapság a betegségek megelőzése és az egészség fenntartása az egyik legfontosabb nemzeti és nemzetközi célkitűzés. Erre irányulnak az egészségmagatartással kapcsolatos kutatások, amelyek az egészséges és az egészségtelen életmód szempontjait vizsgálják. Az egészségmagatartáson belül kiemelten fontos a táplálkozás, mivel az elhízás, és az ebből eredő betegségek súlyos terheket jelentenek egyéni és társadalmi szinten egyaránt. A helyes táplálkozási szokásokat már kisgyermekkortól kellene kialakítani, viszont a serdülőkor az a legérzékenyebb időszak, amely során érdemes odafigyelni a megfelelő mennyiségű és minőségű tápanyagbevitelre, tekintettel az ekkor zajló testi és lelki változásokra. Kutatásunkban ezért is tűztük ki célul középiskolások táplálkozási szokásainak, magatartásának és motivációinak felmérését. Módszerek: Vizsgálatunkat egy budapesti szakgimnáziumban végeztük 97 fő bevonásával. A minta életkorának átlaga 17,4 év szórása 1,5 év volt, valamint 70,1%-uk volt lány. Az adatgyűjtéshez önkitöltős kérdőívet alkalmaztunk. Eredmények: Eredményeink azt mutatják, hogy a vizsgált serdülők körében a reggelizés és a családdal töltött étkezések gyakorisága elmarad a várttól. Az étkezési magatartást vizsgálva megállapítható, hogy az optimizmus, az önkontroll, és kisebb mértékben az énhatékonyság, egészségvédő hatásúak a táplálkozás szempontjából, szemben a pesszimizmussal. Az étkezési motivációk eltérnek az egészséges és egészségtelen ételek fogyasztása terén: míg az előbbiek esetében az egészség a fontos szempont, az utóbbiaknál fontosabbak az érzelmi hatások, a szokások, és akár a társadalmi normák, imázs is. Következtetés: Ezek az eredmények felhasználhatók a fiatalok ételválasztási preferenciáira építő preventív programok kidolgozása során.
Translocation of the conus medullaris during dynamic lumbosacral magnetic resonance imaging in dogs
Authors: Nam Jihye , Kang Kyuyong , Kim Kyeonga , Choi Jeongwoo , Choi Mincheol , Yoon Junghee
Published: June 2021

OBJECTIVE

To investigate the change in the lumbosacral angle (ΔLSA) and conus medullaris (CM) displacement in healthy dogs undergoing dynamic MRI with changes in the posture of their pelvic limbs from neutral posture to flexion or extension posture and to evaluate for potential correlation between ΔLSA and CM displacement.

ANIMALS

9 healthy adult Beagles.

PROCEDURES

Dogs underwent dynamic MRI with their pelvic limbs positioned in neutral, flexion, and extension postures. From T2-weighted sagittal midline plane MRI images, 2 observers measured the lumbosacral angle and CM location in duplicate for each posture for each dog. Intra- and interobserver agreement was assessed, and the Spearman rank correlation coefficient (ρ) was used to assess for potential correlation between ΔLSA and CM displacement for changes in pelvic limb posture from neutral to flexion or extension.

RESULTS

Overall, the mean ΔLSA and CM displacement for changes in posture were 23° and 9.09 mm (caudal displacement) for the change from neutral to flexion posture, 8.4° and −2.5 mm (cranial displacement) for the change from neutral to extension posture, and 32.2° and 11.64 mm (caudal displacement) for the change from extension to flexion posture. The ΔLSA strongly correlated (ρ = 0.705; 95% CI, 0.434 to 0.859) with displacement of the CM.

CONCLUSIONS AND CLINICAL RELEVANCE

The use of dynamic MRI, compared with conventional MRI, will better help to characterize clinically normal and abnormal features of the lumbosacral region of the vertebral column and associated spinal cord during postural changes. Further, when limited translocation of the CM is evident on dynamic MRI, veterinarians should suspect underlying lumbosacral pathophysiologic processes or anatomic abnormalities.
Determination of Quality Characteristics, Phenolic Compounds and Antioxidant Activity of Propolis from Southeastern Mexico
Authors: Sauri-Duch Enrique , Gutiérrez-Canul Cesia , Cuevas-Glory Luis F. , Ramón-Canul Lorena , Pérez-Pacheco Emilio , Moo-Huchin Víctor M.
Published: June 2021

The objective of this work was to investigate the variability of physicochemical parameters, phenolic compounds and in vitro antioxidant activity of propolis collected from different apiaries in southeastern Mexico. A high variability was found in the moisture content (1.96–8.26%), ash (0.66–5.50%) and sensory characteristics of raw propolis from southeastern Mexico, but the raw propolis samples met the requirements of the quality regulations. In the same way, most of the ethanolic extracts also complied with the quality regulations. Of all the extracts, PE2 obtained from Santa Cruz showed the highest values for dry extract, content of total phenolic compounds (TPC), total flavonoids (TF) and antioxidant activity (DPPH and ABTS). The content of the individual phenolic compounds varied according to the geographical location of the apiary, but the PE2 extract resulted in the highest pinocembrin and chrysin content. A positive correlation was obtained between TPC and TF with antioxidant activity. Propolis extracts were classified into two groups through principal component analysis (PCA). These results indicate that the apiary location in southeastern Mexico influenced the characteristics of propolis.
Examining a Model of Human Resource Performance in Tourism Destination After Pandemic
Authors: Ivo Novitaningtyas Dian Marlina Verawati, Andhatu Achsa,
Published: June 2021

During the new normal era after pandemic Covid-19, the tourism destination needs to struggle and adapt for recovery. This process requires optimal human resource performance. The objective of this study is to examine the model of human resource performance in tourism destination after pandemic. Leadership, motivation, and organizational commitment are consider as the antecedents of human resource performance. This study implements a quantitative approach. The data collection method used a questionnaire that distributed to 105 employees in Balkondes as respondent. The data analysis method used Structural Equation Model (SEM) with AMOS. The results show that leadership, motivation, and organizational commitment have a positive and significant effect on human resource performance. The results also show that organizational commitment has mediating effect on the relationship between leadership toward human resource performance, and motivation toward human resource performance.
How Self-Efficacy Drives Job Performance: The Role of Job Anxiety and Intrinsic Motivation
Authors: Razak Nurlaely
Published: June 2021

This study seeks to investigate self-efficacy on job performance through the role of work anxiety and intrinsic motivation. The research sample consisted of 83 employees and ten leaders on the STIEM Bongaya campus, and data analysis used Warp PLS 7.0. This study does not support the hypothesis that the better the self-efficacy, the higher the job performance. So, as a practical implication, self-efficacy is not the main determining factor in determining the value of job performance in tertiary institutions. Interestingly, self-efficacy has a positive and significant effect on work anxiety, and subsequently, job performance is getting better. It was found that the better the self-efficacy, the better the intrinsic motivation, and the better job performance. Hence, the role of work anxiety and intrinsic motivation as a complete mediation variable. The higher the self-efficacy, the higher the anxiety and the higher the job performance, but the impact is not significant or significant. Furthermore, the better the self-efficacy, the higher the intrinsic motivation and higher job performance, but the impact is not significant.
Öz Kendilik Değerlendirmesi, İş Tatmini ve Tükenmişlik İlişkisi Üzerine Bir Araştırma
Authors: ÖRÜCÜ Edip , HASIRCI Itır
Published: June 2021

Bu araştırmanın amacı iş tatmininin tükenmişlik üzerindeki etkisinde öz kendilik değerlendirmesinin düzenleyici rolünü belirlemektir. Araştırmanın evrenini Bandırma ve Ankara’da bulunan kamu kurumunda çalışmakta olan 800 işgören oluşturmakta olup, örneklemini Bandırma ilçesinde çalışmakta olan 271 işgören oluşturmaktadır. Elde edilen verilerle güvenilirlik analizi, frekans analizi, normallik testi, korelasyon analizi ve hiyerarşik regresyon analizi yapılmıştır. Yapılan korelasyon analizinin sonucunda, iş tatmini ile tükenmişlik arasında istatistiksel olarak negatif yönlü ve anlamlı bir ilişki, iş tatmini ile öz kendilik değerlendirmesi arasında istatistiksel olarak pozitif yönlü ve anlamlı bir ilişki, tükenmişlik ile öz kendilik değerlendirmesi arasında istatistiksel olarak negatif yönlü ve anlamlı bir ilişki olduğu görülmüştür. Yapılan hiyerarşik regresyon analizinin sonucuna göre, iş tatmininin tükenmişlik üzerindeki etkisinde öz kendilik değerlendirmesinin düzenleyici rolünün olduğu tespit edilmiştir. Çalışanların öz kendilik değerlemesi algılarında artış gerçekleştikçe tükenmişliğin azalacağı görülmüştür.
Diabetes em foco: relato de experiência sobre projeto de extensão universitária durante a pandemia da COVID-19
Authors: Alencar Beatrice Sousa , Barreto Ana Carolina Mourão , Silva Indira Luz da , França João Victor Coimbra , Nunes Rafael dos Santos , Reitz Suãyne Regina , Silveira Susana Aparecida , Moura Felipe Scipião , Pinto Lucielma Salmito Soares , Nogueira Luciana Tolstenko
Published: June 2021

Objetivo: Detalhar as atividades remotas de educação em saúde para o público diabético, durante a pandemia da COVID-19, organizadas por discentes e docentes do curso de medicina de uma universidade pública no estado do Piauí. Relato de experiência: De janeiro a agosto de 2020, aconteceram capacitações para os discentes lidarem adequadamente com o público alvo. Assim, até dezembro de 2020, foi abordado público alvo de 30 participantes, dos quais 14 tinham Diabetes Mellitus Tipo II, 10 tinham Diabetes Mellitus Tipo I e 6 eram familiares de diabéticos. Vídeos informativos foram criados. Reuniões virtuais com profissionais da saúde ocorreram. 20 participantes tiveram suas demandas individuais melhor gerenciadas pelo sistema de apadrinhamento. Dentre eles, 8 estavam com dificuldades dietéticas, 7 com problemas nas atividades físicas, 5 sem um acompanhamento periódico endocrinológico e 1 apresentava alterações psicológicas, pelo medo das consequências da doença. Considerações Finais: Os participantes enfatizaram a importância do sistema de apadrinhamento e relataram que adotaram hábitos mais saudáveis, mas que tiveram dificuldades devido ao contexto da pandemia. Os alunos desenvolveram habilidades para a relação médico-paciente, sobretudo pela aplicação de técnicas de abordagem comportamental, bem como pelo desenvolvimento de uma escuta empática e humanizada da realidade de cada indivíduo.
Hair transplantation in androgenetic alopecia
Authors: Chouhan Kavish , Roga Gillian
Published: June 2021

Androgenetic alopecia is the most common cause of non-scarring alopecia in men. Even though the past couple of years have seen significant advancements in the management of patterned hair loss. Medical therapy as a standalone treatment remains unsatisfactory and surgical restoration of hair has found to be extremely gratifying as far as male pattern hair loss is concerned. In this article, we will review the latest developments in the field of hair transplantation undertaken in androgenetic alopecia.