bluuebunny/crossref_metadata_2025 huggingface dataset:
Diabetes mellitus gestacional: fisiopatologia e fatores de risco materno-fetais
Authors: Marinho Ana Bárbara da Nóbrega , Dantas Ana Livia Alves , Esmeraldo Liz Matos , Franca Maria do Carmo Pimentel , Henriques Mariana Souza de Miranda , Souza Alysson Kennedy Pereira de , Sousa Daniela Heitzmann Amaral Valentim de , Arruda Isabela Tatiana Sales de
Published: February 2025

O Diabetes Mellitus Gestacional é uma doença hiperglicêmica que afeta as mulheres gestantes. Dessa forma, é imprescindível considerar o aumento da incidência de tal enfermidade, haja vista que ela afeta diretamente a saúde e o bem-estar da mãe e do nascituro. O objetivo deste artigo foi analisar a fisiopatologia e os fatores de risco para essa doença. Para tanto, procede-se a revisão de artigos e periódicos dos períodos de 2008 a 2024 publicados nas bases de dados da SCIELO, Brazilian Journal of Health Review e Internacional Journal of Molecular Science. Desse modo, observa-se que o diagnóstico precoce e o manejo terapêutico adequado são essenciais no acompanhamento pré-natal das gestantes acometidas pelo DMG, o que permite concluir que o estudo dessa temática é profundamente importante para melhorar a qualidade de vida da mãe e do bebê, além de evitar possíveis complicações para ambos.
Terapias gênicas e suas aplicações em Doenças Hereditárias
Authors: Oliveira Maria Rita Honorato de , Sousa Pedro Felipe Silva , Martins Gabriel Oliveira , Simão Estefani Pontes , Martins Lamartine Rodrigues
Published: February 2025

O avanço no campo da genética tem proporcionado descobertas transformadoras, como a elucidação do código genético e o desenvolvimento de terapias gênicas, que têm se destacado no tratamento de doenças hereditárias. Este estudo tem como objetivo analisar os progressos nas terapias gênicas, com ênfase em sua aplicação no tratamento de doenças genéticas, além de avaliar os desafios e as possibilidades dessa abordagem. Para isso, foi realizada uma revisão narrativa da literatura, compilando e analisando os resultados de estudos clínicos e ensaios terapêuticos. Os resultados indicam que as terapias gênicas têm apresentado resultados promissores, como a modulação do gene SMN1 e o uso de células CAR T, mostrando um grande potencial para o tratamento de doenças como a atrofia muscular espinhal (AME). No entanto, desafios como a variabilidade genética entre os pacientes, os custos elevados e as questões éticas envolvidas ainda precisam ser superados. Apesar das barreiras existentes, o futuro das terapias genéticas é promissor, sendo essencial o avanço de pesquisas para garantir sua eficácia e acessibilidade a todos os pacientes, além da necessidade de personalizar os tratamentos com base na genética individual. A continuidade das investigações poderá expandir as possibilidades de tratamento e proporcionar alternativas terapêuticas mais eficazes e acessíveis.
Entre Ruas e Histórias: projeto terapêutico singular na atenção à população em situação de rua
Authors: Santos Ciro Moisés Oliveira Vieira dos , Motta Ana Clara Pellizzaro da , Viana Luiz Filipe de Oliveira , Moreira Miriã Maria Vitoriano , Rocha Samanta Hosokawa Dias de Nóvoa , Barreto Ana Rosa Pessoa Peixoto
Published: February 2025

Introdução: Este relato descreve a aplicação do Projeto Terapêutico Singular (PTS) como ferramenta de cuidado integral e humanizado no contexto do Consultório na Rua, voltado para populações em situação de extrema vulnerabilidade social. Objetivos: Descrever o PTS de uma paciente transexual em situação de rua com múltiplas comorbidades, destacando sua efetividade e relevância para a formação de futuros profissionais de saúde. Metodologia: Pesquisa qualitativa e descritiva realizada em Brasília-DF, com participação de equipe multiprofissional e acadêmicos de medicina, utilizando visitas domiciliares, acompanhamento longitudinal e articulação intersetorial. Resultados: O PTS resultou em estabilização clínica com adesão ao tratamento, redução do uso de substâncias psicoativas, reinserção social com obtenção de benefício social e segurança habitacional, bem como no aprendizado técnico e humanizado aos acadêmicos envolvidos. Conclusão: O PTS demonstrou ser eficaz no cuidado integral de uma paciente em vulnerabilidade, promovendo melhorias clínicas e sociais, além de contribuir significativamente para a formação acadêmica em saúde.
Tratamento restaurador atraumático em pacientes com Transtorno do Espectro Autista - nível de suporte 1: Sequência de casos clínicos
Authors: Silva Mayná Karoline Santana da , Correa Suelen Castro , Cavaleiro Rosely Maria dos Santos , Santos Junior Paulo Bisi Dos , Correa Vânia Castro , Correa Davi Lavareda , Pedreira Juliana de Borborema Garcia , Dias Hércules Bezerra
Published: February 2025

O Transtorno do Espectro Autista (TEA) é uma condição identificada em indivíduos que apresentam alterações comportamentais, sociais e/ou psicológicas, podendo ser fatores que interferem no percurso e na execução do atendimento odontológico realizado pelos cirurgiões-dentistas a esses pacientes. O objetivo deste trabalho foi relatar casos clínicos, enfatizando a importância, a técnica, o manejo e a eficácia do Tratamento Restaurador Atraumático (ART) em pacientes pediátricos com TEA nível de suporte 1. O atendimento odontológico foi realizado em três crianças, com idades entre 5 e 9 anos, no Sistema Integrado de Diagnóstico Oral para Pacientes com Necessidades Especiais (SIDOPE), localizado nas dependências da Faculdade de Odontologia da Universidade Federal do Pará, no período de 8 de março a 27 de junho de 2024. A aplicação da técnica do Tratamento Restaurador Atraumático mostrou-se eficaz e resolutiva na demanda clínica, considerando o comportamento agitado que a maioria dos pacientes apresentou durante a execução do atendimento odontológico.
A synthesis on modern methods in rangeland ecohydrology I
Authors: Dorsett Cameron K. , Archer Steve
Published: February 2025

Rangeland ecohydrology is an emerging and developing field that primarily deals with the nexus of rangeland ecosystems and the hydrologic processes that affect them. In the arid and semiarid rangelands of the American Southwest, capturing and retaining water is crucial to the overall health and functionality of floodplain grasslands. In the Southwestern U.S., the native grasses Big sacaton (Sporobolus wrightii) and Alkali sacaton (Sporobolus airoides) have historically dominated riparian floodplains, including those on the Altar Valley’s Buenos Aires National Wildlife Refuge (BANWR) near Tucson, AZ. However, issues of hydrologic connectivity have grown prevalent on the Refuge due to advancement of altered drainage pathways via channel incision and arroyo formation. Some of these incised channels likely developed due to failed (breached, scoured, or flanked) water retention and diversion structures put in by the U.S. Soil Conservation Service (SCS) in the early 1900’s as part of water infrastructure improvement efforts. Other considerations include land cover erosion due to overgrazing. As these channels further gully after sufficient rainfall the sacaton floodplain disconnects from available runoff via incised channels where ideal rainfall would once inundate floodplain grasslands.
A synthesis on modern methods in rangeland ecohydrology II
Authors: Dorsett Cameron K. , Archer Steve
Published: February 2025

Rangelands provide an abundance of ecosystem services which can be defined as the benefits people obtain from ecosystems. Water is an essential component to such rangeland ecosystems and, therefore, rangelands may also be considered watersheds. The proposed synthesis of rangeland and watershed hydrologic literature aims to address many of the concerns and methods involved in the management of these arid and semi-arid, water-limited (drought and irregular rainfall), dryland ecosystems of the Southwestern United States. Due to these compositional ecosystem factors, problems such as landscape gullying and ecological shifting may take place. Local examples of each of these problems in the Southwest include but are not limited to alterations of surface water runoff patterns due to gully advancement and changes in cover, composition and abundance of vegetation (such as Mesquite trees and Sacaton grasses) due to lack of available moisture. Giving special consideration and study to the hydrologic processes involved in water-limited environments is a crucial component in attempting to address, or even solve, many of the problems or concerns mentioned. Consequently, the management techniques to combat such environmental stresses are numerous, varied, and often limited. It is at this juncture that much of the work conducted on the Santa Rita Experimental Range (SRER), southeast of Tucson, AZ, over the past 100-plus years may be referred to for guidance in future rangeland management decisions. One such experimental management method is the use of “irrigation” or added precipitation to study vegetation and soil response. Finally, other common methods such as the use of state-and-transition models (STMs) and remote sensing technologies to assess vegetation health and prevalence for ecological sites as well as quantify ecosystem services are considered in seeking to synthesize a network for rangeland ecosystem management.
Meta-análise da contribuição genética para características de carcaça e reprodutivas em suínos baseada em modelo de efeitos aleatórios
Authors: Morais Kayo Murilo Almeida de Souza Cruz , Jacó Keila Dutra , Prado Ana Carolina Oliveira , D’Suze Elizangela Zayana Lima , Finco Eline Maria , Lima Nilsa Duarte da Silva , Paiva José Teodoro de
Published: February 2025

O melhoramento genético tem sido essencial para avanços na suinocultura, permitindo maior produtividade e eficiência reprodutiva. Para realizar a seleção destes animais, é importante o conhecimento dos parâmetros genéticos das características de importância econômica dentro do sistema de produção. Contudo, existe uma grande variabilidade de estimativas reportadas na literatura considerando diferentes populações de suínos. Neste sentido, objetivou-se realizar uma meta-análise de herdabilidades para as características peso de carcaça quente (PCQ), espessura de gordura (EG), número total de nascidos (NTN) e número total de nascidos vivos (NTV) em suínos. O estudo utilizou um banco de dados construído a partir de 106 artigos científicos, publicados entre 1980 e 2023, com 219 estimativas de herdabilidade. A análise exploratória dos dados e a meta-análise foram realizadas utilizando-se o software R, por meio do pacote metafor. Os modelos considerando os diferentes estudos como efeitos aleatórios foram significativos e obteve-se um baixo erro-padrão relativo (abaixo de 19,13%) para todas as estimativas. Além disso, os valores do índice I2 variaram de 78,20% a 97,10%, indicando alta heterogeneidade entre os estudos. As herdabilidades ponderadas foram de média magnitude (0,17) para PCQ, alta magnitude (0,51 e 0,46) para EG, e baixa magnitude (0,12 e 0,10, respectivamente) para NTN e NTV. O uso da meta-análise torna-se uma ferramenta útil para sintetizar as informações disponíveis na literatura de forma acurada, fornecendo estimativas valiosas para os programas de melhoramento sobre a variabilidade genética e ambiental das características de importância econômica em suínos.
Prevalência de bactérias patogênicas em peixes abatidos por meio da pesca subaquática
Authors: Coelho Willian Marinho Dourado , Santos Gisele de Carvalho Apolinário , Spada Júlio César Pereira , Storti Silvia Maria Marinho , Rodrigues Bruno Freitas , Lima Carlos Henrique Estelato , Mazieiro Izabela , Freitas João Felipe Azambuja de , Silva Juniely Paniago da , Minin Raquel Elisa Lacal da Cunha
Published: February 2025

Atualmente a pesca subaquática tem se destacado como um dos principais meios para a captura de peixes a partir da utilização de técnicas de mergulho com a utilização de petrechos que envolve o uso de arpões, sendo classificada como uma modalidade de pesca não esportiva. O objetivo desta pesquisa foi analisar a prevalência de bactérias patogênicas na carne de peixes abatidos com o uso de arpões na prática da pesca subaquática. Diferentes espécies de peixes foram capturadas com uso de arpão nos rios Tietê e Paraná, região noroeste do estado de São Paulo. Os peixes abatidos ficaram presos em fieiras dentro da água durante todo o período da pesca até o momento das análises laboratoriais, sendo observado estado de rigor mortis em 100% destes animais.  Durante necropsia do peixe foi constatada a perfuração dos órgãos internos, incluindo estômago e intestinos resultando em extravasamento de conteúdo gastrintestinal e consequente contaminação da carne dos peixes. Foi realizado coleta de material com o uso de swab estéril nos orifícios de entrada e de saída do arpão, bem como da carne do peixe, sendo este material transferido para placas de cultura microbiológica. Foram isoladas numerosas colônias de bactérias como Enterococcus faecalis, Edwardsiella tarda, Enterococcus faecium, Escherichia coli, Staphylococcus saprophyticus, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Listeria spp., Salmonella spp. e Vibrio spp. Resistência bacteriana foi constatada para a maioria dos antibióticos testados sendo que apenas a doxiciclina e a ceftriaxona foram eficazes no teste de sensibilidade. Pode-se concluir com esta pesquisa que o modo de captura e armazenamento dos peixes obtidos por meio da pesca subaquática com o uso de arpão promove a contaminação da carne do pescado, sendo contraindicado o seu consumo, especialmente no preparo de alimentos crus ou mal cozidos devido ao risco da transmissão de patógenos aos consumidores.
ОРГАНИЗАЦИЯ ПРЕДОТВРАЩЕНИЯ ЧРЕЗВЫЧАЙНЫХ СИТУАЦИЙ НА ПРИМЕРЕ РАБОТЫ ГИДРОУЗЛОВ ВОЛЖСКО-КАМСКОГО КАСКАДА
Authors: Гордиенко А.Н. , Рожко О.И. , Петрученко А.И.
Published: February 2025

Безопасное ведение народного хозяйства в сфере управления водными ресурсами, сохранение государственного имущества невозможно без своевременного прогнозирования возможных чрезвычайный ситуаций (ЧС) на объектах водного хозяйства, принятия решений, направленных на предотвращение ЧС или минимизацию их последствий. Основной задачей данного исследования является обзор используемых подходов и принципов в привязке к объектам водной инфраструктуры в целях недопущения возникновения ЧС. Данная статья также акцентирует использованные в работе нормативные положения, материалы МЧС России, Росводресурсов и Росгидромета, которые отражают методический опыт, выработанный, в том числе, в ходе прогностической работы при участии МЧС России в работе Межведомственной рабочей группы по регулированию режимов работы водохранилищ Волжско-Камского каскада. При этом, Волжско-Камский каскад водохранилищ и гидроэлектростанций избран объектом исследования, поскольку является основным инфраструктурным инженерным стержнем функционирования и устойчивого развития социально-хозяйственного комплекса центра Европейской части России. Итогом работы является представление комплекса основных показателей оценки большого водного объекта с позиции прогнозирования возможных чрезвычайных ситуаций.

Safe management of the national economy in the field of water resources management, preservation of state property is impossible without timely forecasting of emergencies at water management facilities, making decisions aimed at preventing emergencies or minimizing their consequences. The main objective of this study is to review the approaches and principles used in relation to water infrastructure facilities in order to prevent the occurrence of emergencies.This article also focuses on the normative provisions used in the work, analytical materials of the EMERCOM of Russia, Rosvodresursy and Roshydromet, which reflect the methodological experience developed, including during the prognostic work with the participation of the EMERCOM of Russia in the work of the Interdepartmental Working Group on regulating the modes of operation of reservoirs of the Volga-Kama cascade. At the same time, the Volga-Kama cascade of reservoirs and hydroelectric power plants has been chosen as the object of research, since it is the main infrastructural engineering core of the functioning and sustainable development of the socio-economic complex of the center of the European part of Russia. The result of the work is the presentation of a set of basic indicators for assessing a large water body from the perspective of predicting possible emergency situations.
Eski Türkçede qod- ve qud- Fiilleri: Fonetik ve Etimolojik Bir Değerlendirme
Authors: Uçar Erdem , Stachowski Marek
Published: February 2025

The article examines the phonetic and etymological aspects of the Old Turkic verbs qod- and qud- to determine whether they represent two distinct lexical items or phonetic variations of a single verb root. By analysing Old Turkic inscriptions in different writing systems, including Turkic Runic, Brāhmī, Manichaean and Uighur scripts, the research explores how the vowel change o ~ u is recorded in historical sources. It takes a comparative approach, examining how these forms appear in different Turkic languages and loanwords in neighbouring languages such as Yeniseian and Slavic. The study also assesses the impact of phonological constraints and orthographic conventions on the transcription of these words. The results suggest that qod- and qud- were historically intertwined, and probably derived from a single root meaning ‘to lower something’ or ‘to move something downward’. Over time, phonetic shifts and dialectal differentiation led to distinct forms that influenced later developments in Turkic languages. The article contributes to the broader discussion of vowel shifts and phonological variation in historical Turkic linguistics.
Kâğıdın Şiiri, Şiirin Kâğıdı: Kâğıdın Klasik Türk Şiirindeki Bazı Yansımaları
Authors: Kutsal Nalan
Published: February 2025

The invention of paper is an important stage in the journey of knowledge. Paper, which has an important place in cultural life, has also been reflected in classical Turkish poetry in various aspects. Poets gave great importance to paper, which made their poems eternal, and they mentioned this important material in their poems in various ways. Poets have given great importance to paper which ensures the immortality of their poems and have mentioned this important material in their poems in various ways. In this study, after explaining the history of paper, its reflections in classical poetry are explained with some striking examples. In classical poetry, which traditionally developed along the in love-beloved line, paper is seen to come to the forefront as a necessary material for poetry. In the couplets mentioning paper, sometimes the paper-text relationship is emphasized, as seen in the example of al kâğıt. Sometimes, as seen in the examples of varaku’t-tayr, Semerkandî and şekerrenk, the type of paper, the place where it was produced and its color are indicated. It is also seen that in the poem, communication with paper and the permanentization of science and poetry with paper are mentioned. The reflection of paper into poetry through different scenes from life also shows the inseparable bond of poetry with life. Poets gave great importance to paper, which is of vital importance for poetry, and showed this value in their poems. Thus, various details about the social life of the period are reflected in the world of poetry.
Tibet Etkili Budist Uygur Metinlerinde Bir ‘Kadın’ Temennisi: Erkek Formunda Yeniden Doğum
Authors: İsi Hasan
Published: February 2025

In Tibetan Buddhism, ‘woman’ is depicted, Dharma is at the center of what is said and religious symbols are positive towards ‘woman’. Images of enlightened female Buddhas frequently appear in the visual arts of Tibetan Buddhism. Spiritual enlightenment in religious teaching, practiced predominantly on the basis of liberated female symbolism, is applicable to both men and women. But considering the history of Buddhism, it can be seen that in Theravāda and Mahāyāna Buddhism, ‘woman’ is in the background and is especially excluded from the teachings and community. ‘Woman’, who does not have a high status in the relevant teachings, is generally an evil, deceptive, lustful and seductive figure. Although there are symbols and narratives in Tibetan Buddhism that show ‘woman’ as a liberating source of spiritual power, the situation is different in some examples witnessed especially in Tibetan-influenced Buddhist Uyghur texts. One of these examples is related to the subject of ‘reincarnation’. In the phase known as Tantric Buddhism, although ‘female’ deities are at the forefront, there is a wish for ‘rebirth of female’ individuals in male form in the relevant texts. This wish is contrary to the principle of equal gender, which is influenced by Tibetan Buddhism. In this respect, the present study consists of evaluations on the examples of kız etözinte tugma-, tişi ažunınta tugma- ‘not to be born in the form of a woman or a female being; being born in male form’ and tişi etözin tegşür- ‘to want to change into a female form; being born in male form’, which are witnessed in Tibetan-influenced Buddhist Uyghur texts. The study will first present the view of the concept of 'woman' in Buddhism and then examine the justification(s) for ‘not being born in the female form’ on the basis of relevant examples.
Nugteren, H. Uigurisches Wörterbuch, Sprachmaterial der vorislamischen türkischen Texte aus Zentralasien. II. Nomina – Pronomina – Partikeln, Band 3: eči – idi. Stuttgart: Franz Steiner Verlag, 2024, pp. XXII+150, ISBN: 978-3-515-13797-3.
Authors: İsi Hasan
Published: February 2025

Nugteren, H. Uigurisches Wörterbuch, Sprachmaterial der vorislamischen türkischen Texte aus Zentralasien. II. Nomina – Pronomina – Partikeln, Band 3: eči – idi. Stuttgart: Franz Steiner Verlag, 2024.
Aydın, E. Köl Tegin Türklerin Yenilmez Savaşçısı. İstanbul: Kronik Kitap, 2024, ss. 336. ISBN: 978-625-6228-12-2.
Authors: Çelik Muhammet
Published: February 2025

Aydın, E. Köl Tegin Türklerin Yenilmez Savaşçısı. İstanbul: Kronik Kitap, 2024.
Kajian Indeks Glikemik Nasi Kombinasi Daun Salam (Syzygium polyanthum) dan Sereh Dapur (Cymbopogon citratus DC)
Authors: Gama Sabaniah Indjar , Tawakal Jalu Iqbal , Prasetya Fajar
Published: February 2025

Daun Salam (Syzygium polyanthum) dan Sereh Dapur (Cymbopogon citratus DC) Merupakan rempah Indonesia yang banyak dimanfaatkan sebagai bumbu masakan. Daun Salam dan Sereh dapur mengandung metabolit sekunder yaitu, alkaloid, flavonoid, saponin dan juga tanin. Senyawa fenolik pada Daun Salam dan Sereh dapur berpotensi sebagai antidiabetes. Penelitian ini bertujuan untuk mengetahui metabolit sekunder dari infusa daun salam dan sereh dapur yang berpotensi pada penurunan indeks glikemik dan kadar gula darah dan untuk mengetahui jumlah kadar sari larut air infusa daun salam dan sereh dapur. Identifikasi metabolit sekunder dilakukan dengan metode skrining fitokimia pada infusa daun salam dan sereh dapur. Hasil penelitian menunjukan infusa daun salam dan sereh dapur sama-sama mengandung senyawa alkaloid, flavonoid, saponin dan tanin. Kadar sari larut air yang didapat pada infusa daun salam adalah 62% dan sereh dapur 34%. Infusa kombinasi daun salam dan sereh dapur 1:1 dapat menurunkan kadar indeks glikemik nasi yang berpengaruh pada penurunan kadar guladarah pada menit ke-60 sampai menit ke-120.
Physical Stability and Antihyperpigmentation Activity of Berenuk (Crescentia cujete Linn) Leaves Ethanol Extract in Cream with Variations of Cremophor RH40 as Surfactant
Authors: Auliasari Dewi Wulandari , Riyanti Winanti Adi , Prihantini Malinda , Shabrina Ayu , Fithria Risha Fillah
Published: February 2025

Indonesia has high exposure to sunlight which can cause skin problems such as hyperpigmentation. Treatment of hyperpigmentation with hydroquinone can cause side effects. Therefore, it is necessary to develop antihyperpigmentation products from natural ingredients to minimize these side effects. Berenuk leaves (Crescentia cujete Linn) have antioxidant activity with an IC50 value of 80.21 µg/ml in ethanol extract. This antioxidant compound can be used to treat hyperpigmentation problems. In its use, Berenuk Leaf Ethanol Extract (BLEE) is formulated in a cream dosage form. Cremophor RH40 is a type of nonionic surfactant that can affect the physical stability of cream. This study aims to determine the effect of Cremophor RH40 on the physical stability of cream preparations and their antihyperpigmentation activity. Cream preparations were made with varying concentrations of Cremophor RH40 5% (F1), 10% (F2), 15% (F3). Physical stability evaluation was tested using the cycling test method. Data were analyzed statistically with paired samples t-test. Analysis of antihyperpigmentation test data in the form of the amount of melanin in all test groups was analyzed for differences using Kruskal Wallis and continued with the Mann-Whitney test. BLEE cream’s physical stability test result show that the most stable formula is formula 1 because it is stable up to the 5th cycle. in contrast, formula 2 only goes up to the 3rd cycle, and formula 3 in the first cycle has experienced 2-phase separation. BLEE cream (F1) has antihyperpigmentation activity because it has an average melanin intensity less than the negative and positive controls.
Formulation, Evaluation And Antibactery Activity Test Of Gastroretentive Mukoadhesive Granul Matrix Earthworm Extract (Lumbricus rubellus)
Authors: Magfirah Magfirah , Alaydrus Syafika , Tandi Joni , Utami Indah Kurnia , Dewi Niluh Puspita
Published: February 2025

Background: Earthworm extract (Lumbricus rubellus) has antimicrobial activity because it produces high levels of the lumbricine compound but is easily denatured in the stomach so that its solubility and biological activity change. Therefore its Application  can  be developed  in the form  of  gastrorentetif mucoadhesive preparation. Objectives: The purpose of this study was to optimize and evaluate the antibacterial activity of gastroretentive mucoadhesive preparation matrix of earthworm extract (Lumbricus rubellus). Material and Methods: The matrix utilized a preparatory technique of applying wet granulation mucoadhesive polymers such as chitosan, HPMC, and sodium CMC with concentrations determined based on simple lattice design resulting in 7 granule formulas. The granule formulas obtained were then evaluated including flow time and dwell angle tests, particle size distribution tests, compressibility tests, dissolution tests, and antibacterial activity tests. Results: The results showed that the flow  rate on the F3 granule  formulation  met the requirements of flow rate  >10 g/s, a consequence of measuring the angle of repose in the F1-F5 formula had good flowability which was below 30o, in contrast to F6 and F7 which had an angle of repose of 30-40o favorable to flowability. The F1-F7 formula was mostly preserved in mesh number 20 sieve with a size of 426-850 ?m, according to the results of particle size distribution utilizing the multistage sieve method, the compressibility index of the F1-F7 granule formula was 10% and the measurement results at the 30 minute showed that the average dissolution of the F1-F3 granules was 97.77%, 97.77%, and 101.22% respectively while the F4-F7 granule formulas did not show slow drug release because at the 30th minute the drug released ranged and the antibacterial activity test of Formula 1-Formula 7 granules is respectively 6 mm, 5.5 mm, 8 mm, 3.5 mm, 4.7 mm, 2.1 mm and 3.3 mm. Conclusions: The results of the evaluation of the characteristics of earthworm extract mucoadhesive gastroretentive granule preparation demonstrated that the preparation met the requirements for granule preparation and exhibited antibacterial properties. Among the seven formulas tested, formula 3 had the highest efficacy of antibacterial activity.
Formulasi dan Penentuan Nilai SPF Lip Balm Ekstrak Kulit Buah Delima Hitam (Punica granatum L.) dengan Variasi Konsentrasi Basis Beeswax dan Carnauba Wax
Authors: Endriyatno Nur Cholis , Walid Muhammad , Nurani Kamillia , Aifa Alfaena Laila
Published: February 2025

Bibir merupakan bagian pada wajah yang mempengaruhi persepsi estetis. Bibir merupakan bagian yang rentan terhadap kerusakan yang disebabkan oleh lingkungan seperti sinar matahari. Salah satu solusi untuk mengatasi permasalahan tersebut yaitu dengan menggunakan lip balm yang mengandung tabir surya. Efektivitas sediaan tabir surya didasarkan pada nilai Sun Protection Factor (SPF) yang menunjukkan kemampuan produk tabir surya dalam melindungi kulit dari paparan sinar UV.  Ekstrak kulit delima hitam dengan konsentrasi 0,5% telah teruji memiliki nilai SPF yang tinggi. Tujuan penelitian ini adalah untuk melakukan formulasi sediaan lip balm ekstrak kulit delima hitam (Punica granatum L.) dengan basis beeswax dan carnauba wax. Kulit delima hitam dilakukan ekstraksi menggunakan metode maserasi dengan etanol 96%. Sediaan lip balm dibuat dalam 4 formula dengan perbandingan basis beeswax dan carnauba wax yaitu F1(1%:10%), F2(3%:8%), F3(5%:6%), F4(7%:4%) Pengujian terhadap sediaan lip balm meliputi uji organoleptis, uji homogenitas, pengukuran pH, uji iritasi, uji daya lekat, uji daya sebar, uji kelembapan, uji kesukaan, uji daya oles, uji viskositas, dan uji SPF. Pengujian aktivitas tabir surya lip balm ekstrak kulit delima hitam dilakukan dengan metode spektrofotometri UV-Vis. Berdasarkan uji fisik, nilai SPF, dan uji statistik, F4 dengan konsentrasi beeswax dan carnauba wax 7%:4% merupakan formula terbaik.
Characteristics of Four Variants of Kombucha Tea as Candidate of Functional Health Drink
Authors: Martihandini Nooryza , Rochimat Imat
Published: February 2025

Daun teh diketahui memiliki kandungan senyawa  fenolik tinggi yang dapat menetralkan radikal bebas penyebab berbagai penyakit degeneratif. Proses fermentasi infusa daun teh dengan SCOBY (Symbiotic Culture of Bacteria and Yeast) akan menghasilkan minuman kombucha dengan aktivitas antioksidan yang lebih tinggi. Penelitian ini bertujuan untuk membuat dan mengevaluasi minuman teh kombucha. Metode penelitian menggunakan desain eksperimental laboratorium. Minuman kombucha disiapkan dari 4 varian teh berbeda yaitu teh hitam, teh hijau, teh putih dan teh oolong. Masing-masing infusa teh ditambahkan sukrosa dan difermentasi selama 14 hari dengan kultur SCOBY. Kombucha dievaluasi karakteristiknya meliputi organoleptic, aktivitas antioksidan, uji kandungan total senyawa fenolik, total asam, total gula, dan nilai pH. Hasil penelitian menunjukkan bahwavarian teh yang digunakan mempengaruhi karakteristik kombucha yang dihasilkan. Kombucha teh hitam memiliki aktivitas antioksidan paling tinggi dengan nilai  persentase penghambatan radikal sebesar 82.38 ± 0.08%.Kadar fenolat total dari teh kombucha berada pada rentang 0,040 – 0,082%. Proses fermentasi menghasilkan asam organik dan mengurangi kandungan gula dalam kombucha. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa kombucha memiliki aktivitas menangkal radikal bebas sehingga memiliki potensi untuk dikembangkan sebagai minuman fungsional kesehatan.
Identifikasi Metabolit Bioaktif pada Asam Jawa (Tamarindus indica L.) menggunakan Komputasi Dinamika Molekuler untuk Penargetan HER-2 Kanker Payudara
Authors: Ramadhan Dwi Syah Fitra , Indraswari Ni Luh Astri , Hakim Supartina , Rusli Rusli , Nurisyah Nurisyah , Asikin Asyhari , Fakih Taufik Muhammad , Aksar M
Published: February 2025

The HER-2 (Human EGF Receptor-2) receptor is a receptor known to be strongly correlated with carcinogenesis and a worse prognosis in breast cancer patients. One of the native Indonesian plants that has been reported to inhibit breast cancer growth is tamarind (Tamarindus indica L.) which is known to contain various active metabolites. However, until now, the molecular activity of each of these metabolites has not been known. and one of the highly accurate simulation methods commonly used is molecular dynamics simulation. This study aims to understand the binding stability of active metabolites in tamarind computationally using molecular dynamics. The simulation begins with the preparation of 3D structures of ligands and receptors. The ligand of active metabolite from tamarind tree was obtained from KnapSack natural compound database, and the 3D structure of HER-2 receptor was obtained from PDB site with code 3PP0 and resolution of 2.25 Å. Furthermore, molecular tethering was performed using Autodock4 software. A high-performance computer was used for molecular dynamics simulation with Gromacs 2016 software for 100 nanoseconds (ns). Afterwards, molecular affinity analysis was performed, including RMSD (Root Mean Square Deviation) and RMSF (Root Mean Square Fluctuation). The analysis results showed that of the 6 compounds found in tamarind plants, the orientin compound showed the most favorable molecular Tethering activity with a value of -8.41 Kcal/mol. Although still higher than the natural ligand, the value is close to the value of the natural ligand with a difference of 1.8 Kcal/mol, which is -10.21 Kcal/mol. Furthermore, orientin showed very similar stability to the native ligand, as observed from the RMSD and RMSF analysis. In conclusion, the compound orientin found in tamarind has the potential to be a lead compound for inhibiting HER-2 in breast cancer.
Kualitas Hidup Pasien Diabetes Melitus dan Hipertensi dalam Program Penyakit Kronis (Prolanis) di Indonesia: Narative Review
Authors: Rahmawati Dewi
Published: February 2025

Penyakit kronis menurut WHO tahun 2008 menyumbang kematian hampir sepertiga dari jumlah kematian. Prolanis merupakan sistem pelayanan kesehatan dan pendekatan proaktif yang dilaksanakan secara terpadu dengan melibatkan peserta, fasilitas kesehatan, dan BPJS Kesehatan Prolanis berfokus pada dua penyakit: hipertensi dan diabetes. Dua penyakit ini memiliki prevalensi yang cukup tinggi di Indonesia. menganalisis tingkat kualitas hidup pasien diabetes melitus dan hipertensi dalam Prolanis di Indonesia dan faktor yang mempengaruhi kualitas hidup pasien melalui tinjauan review. Penelusuran literatur dilakukan di bulan Juni-Juli 2023 menggunakan mesin pencari google scholar. Jurnal dipilih berdasarkan kriteria inklusi dan eksklusi melalui proses penilaian kritis. Hasil tinjauan dari 18 jurnal menunjukan secara sistematik menunjukkan kualitas hidup pasien kategori baik yang mempengaruhi oleh beberapa faktor keaktifan peserta dalam grup, dukungan lingkungan dan konseling apoteker.
Pristane modulates specific changes on T cell dependent pathway of lupus in non-F1 BALB/c mice
Authors: Indriyanti Niken , Arifianti Lusiana , Soeroso Joewono , Khotib Junaidi
Published: February 2025

Animal modeling for lupus is a crucial step in the process of discovering efficacious drugs. There are many drug candidates that have potential benefits for the treatment of lupus, but finding an appropriate model remains challenging. The appropriate model based on the literature is an induction model that uses 2,6,10,14 tetramethylpentadecane (TMPD) in female Balb/c mice. The TMPD increases the probability of damage beyond lupus, to the joint and kidneys. Therefore, the purpose of this study was to develop a lupus model by TMPD to test a drug candidate. The experimental method was measuring many biomarkers involved in the TMPD mechanism to obtain lupus-like disease mice. We measured CD4+CD25+FOXP3+ and CD4+CD62L+ T-regs, CD123+IFN-?+ dendritic cells (flow cytometry); total leukocytes (Turk staining); anti-Sm antibody (ELISA); and renal and joint histology (HE staining). After the 6th month, there were reduction (p<0.05) of the T regulatory percentage of CD4+CD25L+ T cells (Naïve=19.39±3.06%, TMPD-treated=5.72±3.43%) and CD25+FOXP3 + T cells (Naïve=10.32±4.47%, TMPD-treated=7.70±4.47%), meanwhile, the IFN-? increased significantly (p<0.05), (Naïve=6.92±8.67%, TMPD-treated=11.42±0.95%), and the total leukocytes increased (p<0.05) (Naïve=9,800±1,698, TMPD-treated=17,500±1,490 cells/mm3). The anti-Sm antibody was also present in the TMPD-treated mice as one cause which led to renal and joint structural disorders. The biomarkers were analyzed by using Independent T-test, so this positive lupus model with its tested biomarkers is valid and can be used to test drugs for lupus.
Determination of Vitamin C Levels in Various Chilli (Capsicum sp) Varieties and In-Silico Activity Assessment
Authors: Dwisari Fath , Dermawan Abdurraafi' Maududi
Published: February 2025

Chili peppers are acknowledged as one of the fruits endowed with a notable vitamin C content, a crucial nutrient integral to various physiological processes. These include collagen synthesis, bone and tooth formation, wound healing, and bolstering the immune system's defense against infections. Vitamin C, as a water-soluble compound, is susceptible to degradation when exposed to atmospheric conditions. Hence, careful preservation of chili peppers is imperative to maintain their vitamin C levels. The primary objective of this study is to discern the concentrations of vitamin C within three distinct stages of chili pepper ripeness: young, semi-ripe, and fully ripe. The methodology employed in this investigation entails UV-Vis Spectrophotometry, with a maximal wavelength for vitamin C quantification established at 265 nm. This approach yielded absorbance values of 0.696, 0.564, and 0.478 for the respective stages. Quantitative analysis reveals that the vitamin C concentrations in young, semi-ripe, and fully ripe chili peppers are 8.1397 ppm, 5.9559 ppm, and 4.5313 ppm, respectively. These findings unequivocally demonstrate that vitamin C content is significantly higher in young chili peppers when compared to their semi-ripe and fully ripe counterparts. The docking results for capsaicin ligands yielded Gibbs energy (?G), Ki and IC50 value -6.14 kkal/mol, 31.34 µm and 19.143 ppm, respectively. The result indicate that capsaicin exhibited good interaction to catalytic site of glycogen phosphorylase which could serve as a potential antidiabetic agent.
Uji Aktivitas Vasodilatasi Ekstrak Etanol Buah Okra (Abelmoschus Esculentus) dengan Parameter Kadar Nitrit Oksida (NO)
Authors: Hafidah Hafidah , Purwidyaningrum Ika , Keswara Yane Dila
Published: February 2025

Penyakit jantung iskemik (IHD) adalah suatu kondisi medis jantung tidak mendapatkan oksigen dan nutrisi yang cukup karena adanya penyempitan atau sumbatan pada arteri koroner. Efek vasodilatasi pada IHD dapat membantu mengatasi beberapa komplikasi yang timbul dari penyakit ini. Buah okra (Abelmoschus esculentus) merupakan tanaman yang berpotensi memberikan efek vasodilatasi karena mengandung kuersetin. Tujuan penelitian ini adalah menguji aktivitas ekstrak buah okra (Abelmoschus esculentus) dan dosis efektifnya dalam memberikan efek vasodilatasi. Buah okra diekstraksi dengan metode maserasi menggunakan pelarut etanol 70%. Penelitian ini menggunakan hewan uji tikus putih (Rattus novergicus) jantan galur Sprague Dawley dengan variasi tiga dosis ekstrak buah okra yaitu dosis 75 mg/kg bb, 150 mg/kg bb, dan 300 mg/kg bb. Digunakan kontrol positif Isosorbide mononitrat dan kontrol negatif CMC 0,5%. Aktifitas vasodilatasi ekstrak buah okra diamati melalui parameter kadar nitrit oxide. Data hasil pengamatan dari masing-masing parameter dianalisis dengan menggunakan one way ANOVA. Hasil penelitian menunjukan bahwa ekstrak etanol buah okra (Abelmoschus esculentus) dapat memberikan aktivitas efek vasodilatasi terhadap tikus putih (Rattus novergicus) jantan galur Sprague Dawley. Ekstrak buah okra yang memiliki dosis paling efektif adalah dosis 75 mg/kg bb tikus.
Uji Akltivitas Antioksidan, Kadar Flavonoid, dan Fenolik Total Ekstrak dan Fraksi Daun Asam Jawa (Tamarindus indica L.)
Authors: Nainggolan Rully Mukti , Rahayu Mamik Ponco , Rejeki Endang Sri
Published: February 2025

Daun Asam Jawa (Tamarindus indica L.) merupakan suatu tanaman yang mengandung senyawa metabolit sekunder berupa fenolik dan flavonoid. Senyawa tersebut berpotensi sebagai antioksidan alami untuk mencegah terjadinya penyakit degeneratif. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan, kadar flavonoid, dan fenolik total pada ekstrak, fraksi n-heksan, etil asetat dan air daun Asam Jawa. Daun Asam Jawa diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%, kemudian difraksinasi. Ekstrak dan fraksi daun Asam Jawa diuji kandungan kimianya dengan metode reaksi tabung, diuji aktivitas antioksidan menggunakan metode DPPH, ditetapkan kadar flavonoid totalnya dengan AlCl3 menggunakan baku kuersetin, dan ditetapkan kadar fenolik totalnya menggunakan baku asam galat dengan alat instrumen spektrofotometri UV-Vis.Hasil menunjukkan bahwa ekstrak, fraksi n-heksan, etil asetat, dan air daun Asam Jawa memiliki aktivitas antioksidan dengan nilai IC50 berturut-turut sebesar 44,53 ± 0,8; 306,61 ± 2,23; 27,27 ± 1,02; dan 47,04 ± 1,30 ppm, sedangkan baku kuersetin memiliki nilai IC50 sebesar 2,83 ± 0,04 ppm. Ekstrak etanol, fraksi n-heksan, etil asetat dan air daun Asam Jawa memiliki kandungan flavonoid total berturut-turut sebesar 8,52±0,29; 4,61±0,14; 24,43±1,97 dan 14,52±0,20 QE mg/g, sedangkan fenolik totalnya sebesar 57,21±0,44; 42,55±0,32; 93,31±0,62; dan 44,67±1,23 GAE mg/g. Hasil penelitian ini menunjukkan bahwa fraksi etil asetat memiliki aktivitas antioksidan terkuat dengan kategori sangat kuat, serta memiliki kadar flavonoid dan fenolik total tertinggi dibandingkan dengan ekstrak dan fraksi lainnya.
Analisis Rasionalitas Penggunaan Obat Antihipertensi Pada Pasien Geriatri di Rumah Sakit X Periode Tahun 2023
Authors: Mukti Gabriella , Harsono Samuel Budi , Cahyo Lukito Mindi
Published: February 2025

Hipertensi terjadi apabila seseorang mempunyai tekanan darah diatas 140/90 mmHg. Seseorang berusia ? 45 tahun memiliki resiko terkena hipertensi 8,4 kali lebih besar dibanding dengan usia ? 45 tahun. Tujuan penelitian ialah mengetahui rasionalitas obat antihipertensi pada kelompok geriatri di Instalasi Rawat Inap Rumah Sakit X tahun 2023 mengacu pada indikator tepat indikasi obat, tepat kondisi pasien, tepat pemilihan obat, dan tepat dosis. Penelitian menggunakan rancangan pendekatan cross sectional dengan melihat data rekam medik pasien hipertensi kelompok usia geriatri di Instalasi Rawat Inap Rumah Sakit X periode 2023 melalui teknik purposive sampling. Analisis hasil yang dilakukan mempertimbangkan pemakaian obat pada pedoman yang telah ditetapkan. Menurut penelitian, golongan CCB merupakan antihipertensi yang paling banyak digunakan. Kriteria JNC 8 digunakan sebagai standar pembanding pada data penelitian yang didapatkan. Pada penelitian ini ditemukan kesesuaian tepat dosis serta tepat indikasi obat sebesar 100%, tepat kondisi pasien sebesar 93,75%, dan tepat pemilihan obat sebesar 92,5%. Berdasarkan uji statistik chi?square ada korelasi yang signifikan antara rasionalitas penggunaan obat antihipertensi dengan outcome klinis pasien hipertensi usia geriatri di Rumah Sakit X.
Potensi Nanogel Limbah Biji Alpukat (Persea americana Mill.) Sebagai Antioksidan Pencegah Penuaan Dini Pada Kulit Wajah
Authors: Idham Syamsinar , Ervianingsih Ervianingsih , Arini Arini , Rasyid Rizky Nayzila
Published: February 2025

Setelah Brasil, Indonesia memiliki keanekaragaman hayati tertinggi kedua di dunia. Saatini semakin banyak orang yang memilih menggunakan pengobatan tradisional karenakemudahan hidup dan semakin populernya pengobatan kontemporer. Berdasarkan pengetahuan yang tinggi, salah satu cara paling sederhana untuk mendapatkanantioksidan adalah melalui limbah biji alpukat (Persea americana Mill.). Penelitiansebelumnya menunjukkan bahwa kandungan metabolit pada alpukat memiliki aktivitas antioksidan. Antioksidan sangat penting untuk melindungi jaringan tubuh darikerusakan yang disebabkan oleh radikal bebas. Sebagai upaya menghentikan penuaan dini akibat radikal bebas, tujuan penelitian ini adalah untuk mengkaji aktivitas antioksidan formulasi nano gel dari limbah biji alpukat (Persea americana Mill.) dengan metode DPPH yang sebelumnya diawali dengan uji daya lekat dengan melihat seberapa lama daya lekat yang dihasilkan dari sediaan, uji stabilitas dengan melihat bagaimana kestabilan suatu sediaan dengan suhu penyimpanan yang ekstrim, uji homogenitas dengan melihat apakah sediaan yang dibuat tercampur rata, uji daya sebar dengan melihat seberapa lebar ukuran daya sebar suatu sediaan , uji pH dengan melihat apakah pH dari sediaan aman untuk kulit wajah, dan uji mutu organoleptik dengan melihat berbagai bentuk dari sediaan. Berdasarkan temuan penelitian sebelumnya, setiap formulasi pada penelitian ini memenuhi persyaratan nano gel yang baik berdasarkan literatur. Dimana uji organoleptik pada F1, F2, Dan F3 mempunyai bentuk gel, berwarna orange kecoklatan, dan memiliki aroma alpukat yang tidak mengalami perubahan selama selama pengujian. Hasil uji pH F1 5, F2 5 dan F3 5; uji daya sebar F1 3,9cm, F2 3,1cm dan F3 3,9cm; uji homogenitas F1, F2 dan F3 semuanya homogen; uji daya lekat F1 3,46 detik, F2 1 detik dan F3 2,54 detik; kemudian uji stabilitas uji yang terbaik pada F1; dan ujiantioksidan F1 52.72 kuat, F2 227.16 sangat lemah dan F3 140.54 sedang. Dari ketiga Formula tersebut gel yang paling baik dari segi fisik dan efektivitas adalah formula 1.
Aktivitas Fagositosis Ekstrak Etil Asetat Daun Binahong dari Borobudur untuk Imunomodulator Pandemi COVID-19
Authors: Bunga Cut Dewi , Haresmita Perdana Priya , Rianawati Luluc , Nurkhayati Nurkhayati , Azizah Bilqis Rahil , Latifah Elmiawati , Hermawansyah Adi
Published: February 2025

Kawasan penghasil tanaman herbal ditemukan di daerah Borobudur, Jawa Tengah. Tanaman herbal dapat dimanfaatkan sebagai bahan fitofarmaka yang dapat diolah menjadi bahan dasar obat herbal. Berdasarkan data hingga minggu keempat bulan Juli 2023 dari Kementerian Kesehatan Republik Indonesia menyatakan bahwa terdapat 8.245 kasus Covid-19 yang aktif sampai saat ini. Banyak fenomena yang dilakukan oleh masyarakat selama pandemi Covid-19 salah satunya masyarakat Indonesia menggunakan tanaman herbal yang diolah menjadi jamu guna menambah imunitas tubuh pada pandemi Covid-19. Tanaman yang dapat dimanfaatkan adalah tanaman Binahong (Anredera cordifolia). Penelitian tersebut penting dilakukan karena dapat memberikan alternatif sebagai bahan baku obat imunomodulator dari bahan alam yaitu ekstrak etil asetat daun Binahong dari Borobudur. Tujuan dari penelitian untuk mengetahui efek imunomodulator ekstrak etil asetat daun Binahong yang terdapat di daerah Borobudur, Jawa Tengah yang menggunakan metode maserasi dengan mengukur aktivitas fagositosis dan indeks fagositosis. Peneliti menggunakan 30 mencit yang terbagi menjadi 6 kelompok, masing-masing kelompok memiliki 5 mencit dengan perlakuan positif, perlakuan pelarut dan kelompok dosis 25mg/kgBB, 50mg/kgBB, 75mg/kgBB dan 100mg/kgBB. Uji ANOVA One Way digunakan untuk menganalisis data penelitian ini. Berdasarkan analisis data yang dilakukan, aktivitas fagositosis sel makrofag pada parameter indeks fagositosi menunjukkan dosis efektif yang dapat memberikan efek imunomodulator adalah 100 mg/kgBB. Peneliti dapat menyimpulkan bahwa ekstrak etil asetat daun binahong (Anredera cordifolia) dengan dosis 100mg/kgBB menunjukan aktivitas imunomodulator secara signifikan dan mengandung senyawa metabolit sekunder flavonoid.