bluuebunny/crossref_metadata_2025 huggingface dataset:
Problems with differential diagnostics of seborrheic dermatitis and plaque psoriasis by the exampleof a particular case study
Authors: Samtsov A V , SAMTSOV A V
Published: February 2022

A clinical case of psoriasis with involvement of scalp and armpits areas is presented. Differential diagnosis was made
between psoriasis and seborrheic dermatitis. The diagnosis of psoriasis was confirmed morphologically. Mometasone
furoate lotion was selected for topical therapy of intertriginous areas (armpits), and the symptoms were eliminated after
one week of treatment. For the reason of extensive scaling, betametasone plus salicylic acid lotion was administered to
the scalp area, with significant symptoms improvement by 14th day of treatment. This case illustrates the importance of
proper choice of the form of therapy, namely, topical steroid - mometasone furoate, with proper consideration of the
characteristics and localization of inflammatory process.
Sinus histiocytosis (Rosai-Dorfman disease): a clinical observation
Authors: L'vov A N , Voloshchuk I N , Varshavskiy V A , Gorbacheva Yu V , Bobko S I , LVOV A N , VOLOSHCHUK I N , VARSHAVSKY V A , GORBACHEVA YU V , BOBKO S I
Published: February 2022

The authors characterized a heterogeneous group of a rare disease - Langerhans and non-Langerhans cell histiocytosis,
and analyzed key differential and diagnostic differences between these forms of the disease. A very rare case of non-
Langerhans cell histiocytosis (Rosai-Dorfman disease) in a female patient aged 63 with the subsequent spontaneous
regression of eruptions was described. Key skin manifestations of the Rosai-Dorfman disease included papular eruptions
of the typical intense pink color with a yellowish and brown tint. Morphologic changes were characterized by proliferation
of histiocytes and accumulation of different lipids and pentalamellar markers (S-100 protein, СD 14, СD 68, lysozyme)
in their cytoplasm. Though the Rosai-Dorfman disease usually involves lymph nodes, this case was characterized by
unaffected nodular structures.
Role of polymorphisms of PERP gene in the development of acantholysis in patients with pemphigus vulgaris
Authors: KUBANOV A A , MICHENKO A V , ABRAMOVA T V , KOZHUSHNAYA O S , FRIGO N V , ZNAMENSKAYA L F
Published: February 2022

Goal. To determine the nucleotide protein-coding PERP gene sequence and assess the relation between the revealed mutations/polymorphisms and development of true acantholytic pemphigus as well as particular features of its course. Materials and methods. The protein-coding PERP gene DNA sequence was studied by the sequence analysis method in 18 patients with true acantholytic pemphigus. Results. Two polymorphisms were discovered in patients with true acantholytic pemphigus in Exon 3 of the PERP gene for the first time: rs648802 (non-synonymous) and rs648396 (synonymous). The incidence of wild type genotypes in the revealed polymorphisms (С/С genotype rs648802 and Т/Т genotype rs648396) in healthy volunteers reliably exceeded that in patients (p = 0.049). Patients with true acantholytic pemphigus are characterized by a higher incidence rate of mutant heterozygous genotypes С/G rs648802 and Т/C rs648396 (p = 0.09). Mutant heterozygous genotypes of the polymorphisms (G/G genotype rs648802 and С/С genotype rs648396) were revealed in patients with the earlier onset of the disease (41-60 years) (p = 0.025) more often while heterozygous genotypes (С/G genotype rs648802 and T/С genotype rs648396) were revealed when the disease developed at the age of 61 or older more often (p = 0.01). Conclusion. Identification of the polymorphous genotype by the sequence method or other molecular methods (e.g. PCR) can be used to forecast the terms when true acantholytic pemphigus can emerge in genetically inclined patients. However, it should be noted that it is necessary to specify the preliminary results obtained based on a greater sample of patients with true acantholytic pemphigus.
Association of polymorphisms in TNFAIP3 and TNIPI genes with predisposition to the development of psoriasis in the Russian population
Authors: KUBANOV A A , KOZHUSHNAYA O S , FRIGO N V , MINEYEVA A A , ZNAMENSKAYA L F , CHIKIN V V
Published: February 2022

Goal. To study polymorphisms in TNFAIP3 (rs610604) and TNIPI (rs17728338) genes in a sample of psoriasis patients and healthy volunteers from the Russian Federation. Materials and methods. By using allele specific hybridization methods in the form of real-time PCR and RFLP assay (Restriction Fragment Length Polymorphism), single-nucleotide polymorphisms of fragments of the following genes associated with predisposition to the development of psoriasis were studied in whole blood samples taken from psoriasis patients (n = 286) and healthy volunteers (n = 89): TNFAIP3 (rs610604) and TNIPI (rs17728338). Results. Psoriasis patients had a reliable increase in the frequency of the A/C heterozygous genotype of rs610604 polymorphism of the TNFAIP3 gene and A allele of rs17728338 polymorphism of the TNIP1 gene (A/G and A/A genotypes), which makes it possible to treat carriers of these genotypes as people with predisposition to the development of psoriasis, and to treat A/C genotypes of rs610604 polymorphism and A/G and A/A genotypes of rs17728338 polymorphism as predictors of the development of psoriasis in the Russian population. Conclusion. these data broaden the perception of genetic factors associated with the development of psoriasis in persons from the Russian population.
Program for the evaluation of the quality of medical products for syphilis diagnostics
Authors: Kubanov A A , Rotanov S V , Frigo N V
Published: February 2022

The article presents quality monitoring data for over 300 batches of medical products for syphilis diagnostics performed by GNTsDK in 2003—2011. It was demonstrated that the result made it possible to ensure the necessary level of the diagnostic efficacy of medical products to be used in medical institutions in the Russian Federation for the purposes of syphilis diagnostics (clinical sensitivity and specificity: min. 95%, reproducibility of results: 100%). To ensure the quality of medical products for diagnosing sexually transmitted diseases including syphilis, FGBU GNTsDK (Ministry of Health Care of the Russian Federation) developed and implemented the Voluntary Quality Control Program for Medical Products for Diagnosing STDs in the Russian Federation in 2006. The Program provides for quality control for batches of medical products, centralized control and information about its results to heads of specialized dermatovenerological medical institutions engaged in syphilis diagnostics, and will also improve the quality of studies for the purposes of syphilis diagnostics using a controlled set of chemicals.
Diagnostics of early forms of syphilis by the chemiluminescence immunoassay method
Authors: FRIGO N V , MANUKIAN T YE , ROTANOV S V , KATUNIN G L
Published: February 2022

Goal. Assessment of the diagnostic efficacy of the chemiluminescence immunoassay (CLIA) method for early forms of acquired syphilis. Materials and methods. The authors examined 237 blood serum samples taken from patients suffering from primary (49), secondary (116) and latent early (72) syphilis as well as from 61 healthy blood donors and 20 persons with false-positive results of serological tests for syphilis. Blood serum samples were tested with the use of CLIA, EIA, passive hemagglutination test, immunofluorescence test and microprecipitation test methods. Results. The authors established that the CLIA method used for diagnostics of early forms of acquired syphilis (when the IMMULITE® 2000 Syphilis Screen test system is used) is characterized by high sensitivity (99.6%), specificity (95.1%), diagnostic efficacy (98.3%), predictive value of positive (95.1%) and negative (98.3%) results, which is sufficient for recommending this method as the screening method for diagnostics of syphilis to be used in large diagnostic centers. The CLIA method may also be used to confirm the diagnosis of syphilis. Conclusion. Based on these results, the authors developed a reverse algorithm for diagnostics of early forms of acquired syphilis beginning with the use of the CLIA method with further use of the nontreponemal method (microprecipitation reaction or other nontreponemal method).
Pathogenetic rationale for the use of skin care products in patients suffering from atopic dermatitis
Authors: Dvoryankova Ye V
Published: February 2022

Filaggrin is a key protein participating in the differentiation of epidermal cells, which prevents any excessive transepidermal water loss and contributes to the maintenance of skin barrier properties. Mutations in the filaggrin gene (FLG) are among the most important factors predisposing to the development of atopy. Today correct skin care comprising the use of moisturizing and softening products forms an integral part of the therapy for patients with atopic dermatitis and an important component of measures aimed at the reduction of the number of exacerbations and extension of the remission.
Experience of treatment of psoriatic patients with monochromic ultraviolet light from excimer lamps in a combination with external drugs
Authors: NEMCHANINOVA O B
Published: February 2022

Goal. Comparative assessment of the efficacy of treating certain forms of psoriasis with monochromic ultraviolet light from excimer lamps in a combination with topical glucocorticosteroids or Kartalin cream. Materials and methods. As many as 22 patients (14 male and 8 female aged 25—62) with different clinical forms of psoriasis received a therapy with monochromic ultraviolet light from excimer lamps three times a week. The course of treatment with monochromic ultraviolet light from excimer lamps comprised 6—12 procedures. Topical glucocorticosteroids (GCS) or Kartalin cream were administered externally. Results. Complete regression of eruptions or essential clinical improvement was achieved against the background of treatment in 86% of the patients. At the same time, a clinically significant reduction of psoriatic symptoms was observed in most of the patients treated with Kartalin cream as soon as after the second or third phototherapy procedure while similar results were noted in the patients who received topical glucocorticosteroids only after the fourth procedure. Conclusion. Treatment of psoriatic patients with monochromic ultraviolet light from excimer lamps in a combination with Kartalin cream ensures a fast and positive clinical effect.
Recessive dystrophic epidermolysis bullosa: a case study
Authors: Epishev R V , Chikin V V , Volnuhin V A , Kappusheva I A , Trukhachev M M
Published: February 2022

The article presents a description of an inherited disease, recessive dystrophic epidermolysis bullosa, in a patient aged 19. The treatment with antibacterial, antiseptic, antianemic and wound-healing drugs, non-adhesive surgical dressings and lowintensive laser light substantially improved the patient’s condition.
Atopic dermatitis: optimizing the topical therapy
Authors: Batyrshina S V , Khaertdinova L A , Malanicheva T G , Khalilova R G
Published: February 2022

Goal. Determination of the skin microbiocenosis in patients with atopic dermatitis (AtD) and evaluation of the treatment efficacy for AtD patients using isoconazole nitrate and diflucortolone valerate. Materials and methods. The authors assessed skin microflora in 168 AtD patients. Skin scrapes were obtained for further microscopy, and inoculation tests were performed. As many as 59 secondary AtD patients were treated with a combination of isoconazole nitrate and diflucortolone valerate as well as methylprednisolone aceponate, drugs from the DARDIA line. The treatment efficacy was evaluated clinically based on the SCORAD index as well as skin microrelief assessed with the use of the Visioscan BW30 video camera. After the treatment with Travocort, the nature and degree of skin colonization with AtD microorganisms were also assessed. Results. The efficacy of topical administration of isoconazole nitrate and diflucortolone valerate as well as methylprednisolone aceponate, drugs from the DARDIA line, was confirmed for the treatment of secondary AtD patients. Conclusion. Making antibiotics and antimycotic agents a part of the complex therapy of secondary AtD patients seems to be expedient for eliminating pathogenic microorganisms.
A comparative, prospective, split-face, blind study of the efficacy of two botulinum toxin type A drugs (Disport® and Xeomin®) used to correct lateral periorbital wrinkles
Authors: ARTEMENKO A R , SAIBEL A V , NIKITIN S S , KURENKOV A L
Published: February 2022

A prospective- blind- split-face- comparative study with evaluation of clinical efficacy- tolerability- and safety parameters of two botulinum toxin A (BTA) products (the one containing complexing proteins — Disport®- Ipsen- France/ abobotulinumtoxinA and the one free from complexing proteins — Xeomin®- Merz Pharma- Germany/incobotulinumtoxinA) used for correction of lateral periorbital wrinkles (crow's feet) was performed (at that- electromyographic evaluation of changes in functions of the orbicular muscle of eye was performed for the first time). Materials and Methods. Single injections of both BTA products with equal dose ratio of 3:1 (27 IU Disport® and 9 IU Xeomin®) were performed simultaneously to the right and left side half of the face (orbicular muscles of eye)- respectively- to each of 20 volunteers (women at the age of 40.9) with marked and moderate lateral periorbital wrinkles (2—3 degree according to 4-point Facial Wrinkle Scale/FWS). Clinical and electromyographic assessment was performed 2 weeks- 4 and 6 months after injections. Results. The effect of single dosing of Disport® and Xeomin® did not significantly differ at all assessment time points: both for primary efficacy criterion and for all secondary efficacy criteria; as well as for clinical evaluation by the investigator-subjects’ self-evaluation- and dynamics of M-response parameters for the orbicular muscle of eye. Good tolerability and safety were registered. Conclusion. Study results provided convincing evidence that Disport® and Xeomin® used in accordance with the proposed protocol had a comparable effect and duration of the effect on lateral periotbital wrinkles and the orbicular muscle of eye.
Analysis of risk factors and clinical and laboratory characteristics of inflammatory diseases of the urogenital tract in women of reproductive age
Authors: SHATALOVA A YU , RAKHMATULLINA M R , Plakhova K I
Published: February 2022

The article presents an analysis of clinical and medical history data of female patients suffering from inflammatory diseases of the lower urogenital tract caused by opportunistic microorganisms. The authors analyzed the results of the bacterioscopic and bacteriological examinations obtained from the patients. They present data on clinically significant associations of microorganisms. The authors studied the dependence of clinical characteristics of the course of the inflammatory process on the nature of associations of inflammatory agents, and presented the results of their study.
Transformation of the resource basis of specialized dermatovenerologic establishments during the upgrading of the healthcare system in Russian Federation
Authors: BUTAREVA M M , MELEKHINA L E , KASPIROVICH M A
Published: February 2022

Representation of the analysis of the restructuring of the resource base for specialized medical organizations with dermatovenerologic profile and procurement of the population with such kind of medical assistance.
Combined pharmaceuticals in the external treatment of acne: modern data
Authors: ARAVYISKAYA E R , SOKOLOVSKY E V
Published: February 2022

The article contains data on the efficiency of ready combined pharmaceuticals in acne treatment and discusses the synergic effect of the new adapalene / benzoyl peroxide combination.
Results of molecular and genetic research of genes ompA, ct135 and tarP C. trachomatis strains collected from patients suffering from urogenital chlamydial infection
Authors: PLAHOVA K I , KOZHUSHNAYA O S , FRIGO N V
Published: February 2022

The article contains results of the molecular and genetic research of genes ompA, ct135 and tarp c. trachomatis in 50 samples of clinical material containing DNA c. trachomatis from patients (women and men) from the Moscow region with the diagnosed urogenital chlamydial infection (UGCI) confirmed by PCR method. The sequencing of the gene ompA allowed to establish, that the prevailing serovar c. trachomatis in the examined selection of UGCI patients was serovar Е (48,0%); other serovars were less often (G — 18,0%, D — 14,0%; F and J — by 8%, К — 4%). The authors revealed authentic associations of the frequency of spreading of Е serovar with non-complicated clinical course of UGCI and the association of the frequency of spreading concerning rare serovars c. trachomatis (G, D, J) — with complications of UGCI in women. Significant mutations of the gene ompА in rare c. trachomatis serovars, аs well as significant mutations of genes ct135 and tarр were revealed more often is samples from women with PID. The obtained data are sufficient to make a conclusion about the possible existing relation between peculiarities of c. trachomatis genotype and the character of the clinical course of the urogenital clamidiosis.
Erythema ab igne in the child being a PC user
Authors: MICHENKO A V , CHIKIN V V , LVOV A N , PASINYAN A G , DNEPROVSKAYA O A
Published: February 2022

The rare dermatosis erythema ab igne was examined. The rarity of the observation is also determined by the factor, favoring the skin disease development, — the use of notebook, which infrared irradiation caused the illness development. Were described such items as reasons of erythema ab igne development, the clinical picture, peculiarities of diagnostics and treatment. Disease outcomes have been considered. Mechanisms of infrared irradiation, as well as its biologic effects have been represented.
Isofil cosmetics for the correction of skin aging
Authors: PASHINYAN A G , KULCHITSKAYA D B , SHAPOVAL E S
Published: February 2022

The article covers issues of age-related changes of the skin. The efficiency and safety of the use of Isofil cosmeceuticals for the correction of age-related changes have been evaluated. Data confirming the clinical efficiency of the use of cosmeceuticals by patients with light and moderate developments of age-related changes of the skin have been provided.
Bloch — Sulzberger syndrome
Authors: RUDNEVA N S
Published: February 2022

The author describes a rare case of dermatosis in children — incontinentia pigmenti. The author also describes manifestations characteristic of the Bloch — Sulzberger syndrome. All stages of the disease are presented in detail.
Combined external therapy of atopic dermatitis complicated with a secondary infection
Authors: SUKHAREV A V , GUTKA V O , PATRUSHEV A V , BONDAR O I , NAZAROV R N
Published: February 2022

The authors discuss the reasons of the violation of the skin barrier in patients suffering from atopic dermatitis and determine the role of pyococcus, dermatomycetes and yeast-like fungi in the development of this disease. They also describe the reasons of failures of the external therapy of atopic dermatitis with the use of combined drugs containing antibiotics. The authors substantiate the possibility of using the Travocort cream in case the disease is complicated with a secondary infection. They also describe their own study of the treatment of eczema herpeticum when the Travocort cream was included in the external therapy.
An open-label prospective clinical study of the efficacy and safety of botulinus toxin type A for the correction of age-related neck skin changes
Authors: GUBANOVA YE I , PANOVA O S , SANCHES YE A , RODINA M YU , STAROVATOVA P A
Published: February 2022

Objective. Assessment of the efficacy and safety of the correction of age-related neck skin changes with the use of botulinus toxin type A (Xeomin). Materials and methods. The study involved 25 women aged 39—65 enrolled according to the inclusion and exclusion criteria. The patients were administered a single subcutaneous injection of Xeomin 60 U in the neck. The efficacy and safety of this procedure was assessed based on the Global Aesthetic Improvement Scale (GAIS) on Day 14 as well as after 2 and 3 months. Results. High efficacy and safety of intracutaneous Xeomin injections at the submaximum dose of 60 u in the medial and lateral platysma bands have been confirmed clinically. The authors suggest an experimental gradining of the age-related neck making it possible to assess and statistically process clinical results of the new method.
Organization of histological diagnostics of dermatoses with the use of video and information technologies
Authors: SAMTSOV A V , BARBINOV V V , RESHETNIK D A , MINULIN I K , BOGDANOV G V , KAVOKIN M K
Published: February 2022

Objective. To assess the efficacy of activities carried out by a dermatovenerology dispensary after the implementation of histological diagnostics of dermatoses with the use of the HISTODERM partner expert system. Materials and methods. The authors studied the results of activities carried out by two dermatovenerology dispensaries (in Surgut and Kazan) where histological diagnostics was implemented on the basis of the HISTODERM partner expert system. A dermatovenerologist used the system in the first institution while an anatomic pathologist used it in the second institution. Results. The quality of diagnostics in both dispensaries grew by 50,5 and 28,0%, respectively. The authors also studied the results of the system use by a consultant performing diagnostics remotely. Being in St. Petersburg, the consultant analyzed scanned imaged of skin histological samples sent from a regional dispensary in Krymsk (the samples were a part of the TELEDERMATOPATHOLOGIST telemedical system). The quality of the diagnostics activities of the dispensary grew by 26.6% in the process of such activities.
Particular features of the immune response in case of neurosyphilis
Authors: NOVIKOV YU A , NOVGORODOVA T I , KIDALOV M B , CHERMOSHENTSEV A A , FILIPPOV S O , ORLOVA L I
Published: February 2022

Objective. To reveal additional laboratory criteria for assessing the affection of the nervous system in case of neurosyphilis. Materials and methods. There was a study of 49 patients with a specific affection of the nervous system. The complex study comprised a clinical examination performed by a dermatovenerologist, a neurologist and an ophthalmologist as well as serologic examination of blood and spinal fluid. The level of IL-6, IL-17 and TNF-α in parallel blood and spinal fluid samples was determined. Results. The authors obtained statistically significant results for the concentration of IL-6 and TNF-α. The increased level of these indices was observed in the spinal fluid of patients with the most severe neurological manifestations of the specific process. Thus, it is evident that changes in this index reflect the severity of affection for all components of the nervous tissue. The described changes demonstrate the autoimmune nature of pathological processes taking place in the nervous system.
Automated assessment of spinal fluid examination results in passivehemagglutination reaction in neurosyphilis diagnostics
Authors: Katunin G L , Frigo N V , Rotanov S V , Kitaeva N V , Nesterenko V G , Suslov A P , Katunin G L , Frigo N V , Rotanov S V , Kitayeva N V , Nesterenko V G , Suslov A P
Published: February 2022

Spinal fluid samples collected from 50 patients suffering from neurosyphilis (key group) and 30 patients with a nervous system
pathology and craniocerebral injuries without any signs of syphilis in the anamnesis (control group) were examined in the course of regulated serological tests to reveal anti-T. pallidum antibodies (complement-fixation test with a treponemal antigen, complementfixation
test with a cardiolipin antigen, immunofluorescence test with whole spinal fluid, ELISA) as well as in the course of TPHA
with the use of modified methods with the end-point dilution of spinal fluid as 1:4. Visual assessment was used to assess the TPHA
results with the determination of the result positivity degree expressed in conditional units - «pluses», along with the automated
assessment using the Criterion 2 hardware system.
Comparative results of visual and instrumental assessments of the spinal fluid study results in TPHA revealed full compliance of the qualitative study results and 97.5% correspondence in the results expressed in conditional units («pluses»), which provides
sufficient grounds for recommending the Criterion 2 automatic diagnostics complex for TPHA image assessment to be used in clinical and diagnostic laboratories in health care institutions for determining treponemal specific antibodies in spinal fluid for neurosyphilis diagnostics.
Studying of relationship of Histocompatibility antigens and N-acetylation phenotype in patients of Uzbek populations with psoriasis
Authors: IBRAGIMOV SH I , MANSUROVA G T , MAMATKULOV U A , MAKHSUDOV M R
Published: February 2022

There studied the distribution of Histocompatibility antigens and N-acetylation phenotype in patients of Uzbek populations with psoriasis and it has been revealed, that HLA antigenes A11, A28, В5, В13 and Cw3 are antigenes of predisposition to presented disease and the individuals with slow N-acetylation phenotype prevail among them. The relationship of more frequent associated Histocompatibility antigens and N-acetylation phenotype marked by the prevalence of patients with a slow phenotype in the dermatosis has been revealed in patients of Uzbek populations with psoriasis.
Administration of epigallocatechin-3-gallate for microdermabrasion
Authors: KHISMATULLINA Z R
Published: February 2022

Rationale of the study As previously demonstrated, epigallocatechin-3-gallate (EGCG) accelerates the formation of the collagenous matrix and at the same time prevents any extraordinary collagen synthesis in the course of wound healing. In addition, EGCG is one of the most potent antioxidants and can inhibit cyclooxygenase-2, which in general lays the basis for studying the possibility to use it as an anti-inflammatory drug after dermabrasion procedures as well as to prevent pathologic cicatrization. Materials and methods. Forty women were divided into two groups (21 patients in the group treated with Egallohit, 10% EGCG, and 19 patients treated with Pantoderm Cream, 5% dexpanthenol). The drugs were applied twice a day for 50 days. Dermabrasion was performed on Days 1, 12 and 24. The patients were examined at Days 3, 15, 27, 36 and 60 of the treatment. Each of them filled in a questionnaire about the facial skin pain and itching. The facial skin humidity, fatness and pigmentation as well as number and depth of wrinkles were also measured. The total skin photodegradation index (by a blinded appraiser) was also assessed at the first and last visit. Results. No statistically significant differences in the number and depth of wrinkles, intensity and duration of facial skin pain and itching as well as skin photodegradation index between the groups both prior to and after the treatment were revealed. Conclusions. EGCG (10% Egallohit Gel) is as efficient for skin protection after microdermabrasion procedures as conventional drugs (5% cream with dexpanthenol).
Role of polymorphism of the androgen receptor gene andnon-random x chromosome inactivation in the pathogenesisof androgenic alopecia
Authors: Mareeva A N
Published: February 2022

The article presents data on molecular and genetic studies of mechanisms of development of androgenic alopecia as well as
correlation between polymorphism of the androgen receptor gene by the CAG repeat length in exon 1 and androgen-dependent
diseases including alopecia.
Role of correction of metabolic disorders in the complex therapy of acne in women
Authors: Perlamutrov Yu N , Gofman V E , Olkhovskaya K B
Published: February 2022

The prevalence and genetic origin of acne explain the urgency of searching for new dermatosis treatment methods. The occurrence
of acne in women is stipulated by hyperandrogynous conditions and is often accompanied with insulin resistance. The
administration of Metformin in the complex therapy of acne in women with insulin resistance contributes to considerable improvement
of the clinical course of dermatosis and achievement of remission for a greater number of patients.
Key lines of research and development works defended at thesis council D 208.115.01, fgu gntsd rosmedtekhnologiy (state research center for dermatovenerology), for academic degrees of doctors and candidates of medical science in 2007-2009
Authors: IVANOVA N K , NIKITINA L V , REZAIKINA A V
Published: February 2022

The subjects of the theses include studies of different prevention, clinics, diagnostics, treatment and forecasting aspects of chronic dermatoses, skin tumors, urogenital infections and syphilis. Doctoral theses solving problems related to the organization of works in dermatovenerology were defended.
According to the analysis of the theses defended in 2007-2009, the methodic level as well as scientific and practical value of the works remain to be high.
Clinical recommendations of the Russian Associationof Dermatologists and Venereologists Dermatovenerology2008 (Part 2. Sexually transmitted infections)
Authors: Chebotarev V V , Zemtsov M A , Chebotareva N V
Published: February 2022

The article is written in the form of a discussion. It examines clinical recommendations regarding sexually transmitted infections
(except for syphilis) being the forerunner of the standard published for management of patients from this category. The authors
assess the clinical recommendations in a positive way. They also express their request about introducing certain amendments and
clarifications in the standard at the time of its publication.
140th anniversary of the chair of skin and venereal diseases at the s.M. Kirov military medical academy
Authors: SAMTSOV A V , RAVODIN R A
Published: February 2022

The article examines stages of development for one of the first Russian chairs of skin and venereal diseases and assess the contribution
made by its staff to dermatovenerology studies.
Treatment of acne in women with various forms of hyperandrogenism
Authors: Golousenko Yu Yu , Perlamutrov Yu N
Published: February 2022

The authors conducted a study of the urine steroid profile in 56 women with acne in order to determine the form of their hyperandrogenism
(HA). A ovarian form of HA was revealed in 28.7% of patients, a mixed form was revealed in 30.9%, and no laboratory
signs of any hyperandrogenic state were revealed in 40.4%. The determination of the HA form enabled the authors to efficiently
select a method of systemic treatment for the patients with the use of hormone drugs and to achieve excellent and good results in
70.4% for women with the ovarian form of HA and in 75.9% for women with the mixed form. As for the group of patients where no
HA form was determined, good and excellent results were observed in 30.4% of women.
Clobetasol propionate (Dermovate) gives new opportunities in the treatment ofdermatoses
Authors: Khlebnikova A N
Published: February 2022

The author provides a review of literature covering studies of the efficacy and safety of a very powerful topical corticosteroid -
clobetasol propionate (Dermovate). It surpasses most topical glucocorticoids by its action and efficacy for steroid-responsive
dermatoses. The drug has several forms convenient for use for different localizations. It is a drug of choice for medium and severe
psoriasis. It is efficient in treatment of a wide range of torpid dermatoses as well as dermatoses resistant to other topical drugs.
This drug is safe under the condition of its reasonable administration. The development of serious complications is possible only
in case of long-term administration of extremely high doses.
Skin rejuvenation with the use of fractional photothermolysis(MultiPlex technology) in a combination with the CAP system
Authors: Kubanova A A , Mikhailova N P
Published: February 2022

A new method of skin rejuvenation with the use of fractional laser photothermolysis (MultiPlex technology) in a combination with
the CAP system is based on the sequential skin exposure to low-intensity radiation with different wavelengths (1,440 nm and 1,320
nm). This method produces much more evident esthetic results than radiation of greater intensity but with one wavelength only.
Efficacy and safety of acnecutan for acne treatment
Authors: SAMTsOV A V , STATsENKO A V , GORBUNOV Yu G , VOLKOVA S V , KhAYRUTDINOV V R
Published: February 2022

Acnecutan represents an innovative form of isotretinoin, having bioavailability The aim of our study was to evaluate safety and clinical efficacy of the drug isotretinoin (Acnecutan) in the treatment of patients with acne of medium-severe and severe. The treatment of 56 patients with acne, until the exchange rate dose of 100-120 mg/kg. The clinical results of the drug Acnecutan indicate a high level of safety and tolerability
IMPLEMENTATION OF CORUPTION CRIMINAL SANCTIONS AGAINTS COUNTRY OFFICERS WHO CONDUCTED CRIMINAL ACT OF CORUPTION DURING COVID 19
Authors: Mulyadi Mulyadi , Pakpahan Elvira Fitriyani
Published: February 2022

Corruption has caused damage to various lives of the people, nation, and country. Pandemic Covid 19 is currently increasingly infecting the Indonesian economy. Corruption is one of the causes of the nation's economic system to decline very rapidly. The purpose of this study is to determine the implementation of criminal sanctions against corruption against unscrupulous state officials who commit criminal acts of corruption during the Covid 19 pandemic. The method used in this study is the Normative Juridical Method. The Corruption Eradication Commission (KPK) will provide stricter penalties for those who commit criminal acts of corruption committed in the midst of the corona covid-19 pandemic. Disaster management is an activity or effort carried out in the context of prevention, mitigation, emergency response and recovery related to disasters carried out before and after a disaster.
HOW CAN ENVIRONMENTAL DISPUTE RESOLUTION BE RESOLVED WITHOUT GOING TO COURT
Authors: Pandiangan Leo Nora Elly AM , Koeswidi Nanin , Silitonga Norti Retiana
Published: February 2022

To protect environmental pollution and/or damage, the government has issued legislation on environmental protection and management supplemented by Ministerial Regulations. Environmental pollution and/or damage can occur due to natural factors and human actions that result in losses to the country and/or society. Environmental polluters and/or destroyers can be prosecuted in court. Before environmental disputes are transferred to court, environmental disputes are first resolved through mediation conducted by a mediator and settled out of court (non-litigation) in accordance with applicable laws. Mediators or the role of third-party services are free and neutral /impartial.
SETTLEMENT OF CONSUMER DISPUTES THROUGH THE CONSUMER DISPUTE RESOLUTION AGENCY AND THEIR PROBLEMS
Authors: Harjono Dhaniswara K. , Panjaitan Hulman
Published: February 2022

In relation to fulfilling their daily needs, the position and existence of consumers in a dominant society are under businessmen. This has caused the potential loss of customers due to the actions of businessmen. It is not unusual for businessmen to exploit consumers for their interests and advantages without thinking and often neglecting the rights of consumers. This has given rise to disputes between consumers and businessmen that need to be resolved thoroughly and fairly, with legal certainty. The Act No. 8 of 1999 concerning consumer protection has regulated the resolution of consumer disputes which can be carried out outside the court through the Consumer Dispute Settlement Agency (BPSK). The existence of BPSK as a consumer dispute resolution institution does not seem to provide maximum protection to consumers because there are many problems, including the process and procedures for resolving disputes at BPSK. Based on the results of the research and analysis carried out, it is concluded that the resolution of consumer disputes through BPSK in terms of time is relatively faster because it has to be decided within a maximum of 21 working days compared to resolving consumer disputes through general courts which take years. But on the other hand, many problems exist related to the existence of BPSK as a consumer dispute resolution institution, including in the institutional sector, BPSK human resources, inconsistent laws, and so on.
Numerical implementation of the Full Waveform Inversion method using the asymptotic solution of the Helmholtz equation
Authors: Гадыльшин К.Г. , Неклюдов Д.А. , Протасов M.И.
Published: February 2022

В работе рассматривается численная реализация метода обращения полного волнового поля на основе асимптотического решения уравнения Гельмгольца. Классическая постановка задачи заключается в поиске минимума штрафной функции, характеризующей среднеквадратичное уклонение модельных данных от зарегистрированных при проведении полевых работ. Для минимизации целевого функционала обычно применяются методы локальной оптимизации, такие как метод сопряженных градиентов. Именно вычисление градиента штрафной функции и является самой ресурсоемкой частью задачи. Асимптотический подход к решению обратной динамической задачи сейсмики заключается в замене дорогостоящей конечно-разностной процедуры расчета функции Грина краевой задачи частотно-зависимым лучевым трассированием. Функции Грина рассчитываются на основании данных о времени пробега вдоль лучей, об амплитуде и о геометрическом расхождении. Серия численных экспериментов для широкоизвестной модели Marmousi демонстрирует эффективность применения такого подхода к реконструкции макроскоростного строения сложноустроенных сред для низких временных частот. При сопоставимом качестве решения обратной задачи применительно к стандартному конечно-разностному подходу скорость расчетов асимптотического метода на порядок выше.

In this paper, we consider the numerical implementation of the Full Waveform Inversion method based on the asymptotic solution of the Helmholtz equation. The standard method finds the minimum of the penalty function, which characterizes the mean-square deviation of the modeled data from the observed ones during conducting the field works. Local optimization methods, such as the conjugate gradient method, are usually used to minimize the objective functional. The calculation of the penalty function gradient is the most resource-intensive part of the task. An asymptotic approach to solving an inverse dynamic seismic problem is to replace the expensive finite-difference procedure for calculating the Green’s function of a boundary value problem by the frequency-dependent ray tracing. The Green’s functions are calculated from data on the travel time along the rays, the amplitude and the geometric divergence. A series of numerical experiments for the widespread Marmousi model demonstrates the efficiency of applying of this approach to the reconstruction of macrovelocity structure of complex media for low temporal frequencies. In comparison with the standard finite-difference approach, applied to solving the inverse problem, the speed of calculations of the asymptotic method is an order of magnitude higher upon comparable quality of the solution.
DEVELOPING INTERACTIVE LISTENING LEARNING MULTIMEDIA TO SUPPORT “BAHASA INGGRIS FOR GRADE TEN” BOOK
Authors: Amal Izzul , Ikhsanudin Ikhsanudin , Bunau Eusabinus
Published: February 2022

This research was conducted to design Interactive Listening Learning Multimedia; an interactive multimedia as a teaching and learning media to support “Bahasa Inggris for Grade Ten” book. The research aims to determine whether the interactive listening learning multimedia as the supplementary teaching media is usable to support “Bahasa Inggris for Grade Ten” book or not. The form of this research is developmental research. The method of this research was design and development research. The researcher applied ADDIE as the procedure. In this research, the researcher only implemented three phases which are analysing, designing, and developing (ADD) because of time limitation. The interview for analysing phase was administered in SMA Muhammadiyah 1 Pontianak. The researcher created the multimedia using Powerpoint. In development phase, the researcher used internal evaluation to make sure that the multimedia is usable. To sum up, it is found that interactive listening learning multimedia is usable to support “Bahasa Inggris for Grade Ten” Book.
DESIGNING “VERBHOUSE” TEACHING MATERIALS TO SUPPORT TEACHING ENGLISH VOCABULARY IN JUNIOR HIGH SCHOOL
Authors: Ramadhan Ikram Wahyu , Ikhsanudin Ikhsanudin , Rahmani Eka Fajar
Published: February 2022

This study aimed at designing a multimedia-based product as supplementary material. It is known as VERBHOUSE. The product purposes were to help an English teacher in SMP Negeri 1 Anjongan teach English Vocabulary, especially English action verbs for year-8 students, and find out if it is suitable in supporting the English teachers. The product materials were designed based on “Bahasa Inggris for year-8 students in Junior High School” textbook. Moreover, the researcher gathered the data through an interview and that was supported with open-ended questionnaires. In analyzing the data, the researcher used an internal analysis. The researcher had developed the product within three phases of ADDIE: Analysis, Design, and Development. The researcher conducted the interview and distributed the questionnaire in the Analysis phase. The researcher then started to design the first draft in the second phase. VERBHOUSE consisted of four main menus, House, Exercises, Guide, and Credit. The product contained 40 English action verbs materials, exciting pictures, sounds, video, and provided explicit texts to the user. Furthermore, in the development phase, the researcher used an internal evaluation to measure the product. From the findings, it is indicated that the VERBHOUSE is suitable for classroom use. In short, this study has relatively succeeded in creating multimedia materials for year-8 students as supplementary materials.
THE OCCURRENCES OF CODE-SWITCHING AND CODE-MIXING IN THE NOVEL ME AND YOU VERSUS THE WORLD
Authors: Lestari Gemi Nastiti , Susilawati Endang , Suhartono Luwandi
Published: February 2022

The objective of this research is to know the most occurrence types of code used in the novel and the purposes that contribute to those occurrences. The data were derived from qualitative technique using a novel as the material. The data were analyzed using manual coding and descriptive qualitative. The result of this research showed that code-switching is the most code used rather than code-mixing. The total of the utterances that used code-switching is 53 in total. Meanwhile, the most type of code-switching that used in the novel is intra-sentential which has 27 in total. There were some purposes that contributed to those occurrences, namely, quoting somebody else, express solidarity, and express disapproval. In the novel, switching a code is used to quote a famous expression, proverb, or writing some well-known figures. Also, it is used to express solidarity, to show the bonding between characters. A status relationship between people may be relevant in choosing the appropriate code. Additionally, express disapproval also can contribute to the occurrence in the novel, to express anger or unpleasant events. Therefore, the three factors are contributed to the occurrence of code-switching in the novel.
Productividad y sostenibilidad del cultivo de sorgo forrajero como alternativa para la alimentación de rumiantes.
Authors: Rios Moyano Diana Katherinne , Conde Pulgarín Abelardo , Rios Moyano Claudia Fernanda
Published: February 2022

El sorgo (Sorghum vulgare) es un cultivo que se ha visualizado, como otra alternativa de alimentación bovina, conservado mediante silo para el ganado bovino, ya que este es altamente funcional con respecto a metodologías tradicionales de alimentación como el pastoreo de forraje nativo o mejorado .El sorgo, se considera como un cultivo con buena adaptación y tolerancia a condiciones de sequía, las cuales son limitantes para otros tipos de forraje; además cuenta con una elevada producción de materia verde y capacidad eficiente de rebrote de las plantas ya que es una especie de rápido crecimiento y necesita menores requerimientos nutricionales. Las particularidades citadas, convierten al sorgo en una opción viable para la utilización en los sistemas de alimentación de producción bovina El presente trabajo evalúa y analiza la productividad y sostenibilidad del cultivo de sorgo para la alimentación bovina, con especial énfasis en la zona de vida bosque húmedo tropical bh-T, como suplemento forrajero; por medio de metodologias de análisis-síntesis, de la sostenibilidad en las dimensiones ambiental, social, económica, institucional y técnica, además mostrar los resultados de evaluación productiva de siete genotipos de Sorgo como base forrajera para la elaboración de silo y así para brindar una herramienta al momento de implementar estrategias de alimentación aplicadas a los sistemas de producción bovina. Se destaca a través del análisis realizado que el sorgo puede ser una alternativa sostenible

y rentable, identificando variedades de sorgo con niveles de producción adecuados en el ecosistema que se desarrollo la investigación. El genotipo ABS 7000, obtuvo el segundo puesto en producción de biomasa en fresco de 66,95 T/ha y una proporción de materia seca intermedia (MS) 18,72 %.
A APLICAÇÃO DAS AÇÕES AFIRMATIVAS NO DIREITO AMBIENTAL
Authors: Silva Filho Erivaldo Cavalcanti e , Koenow Debora Bandeira Dias
Published: February 2022

Este artigo tem por objetivo analisar o mecanismo de políticas de ações afirmativas no direito ambiental. Para tanto, por metodologia dedutiva com pesquisa bibliográfica, considera que ações afirmativas são instrumento de combate ao racismo enquanto meio de concretização do direito à igualdade material. Posteriormente, expostas diferenças entre racismo estrutural, institucional e individual e considerado o direito ao meio ambiente ecologicamente equilibrado como elemento para promoção da sadia qualidade de vida. Exposto ainda o conceito de racismo ambiental, como prejuízo de condições ambientais de grupos vulneráveis. Finalmente, delineada a aplicação das ações afirmativas no direito ambiental, promovendo justiça social e ambiental.
UMA INVESTIGAÇÃO SOBRE A ORIGEM DA HERMENÊUTICA NA TERCEIRA CRÍTICA
Authors: GARCIA JACI RENE COSTA
Published: February 2022

Tendo como objetivo geral investigar o papel da estética kantiana para a hermenêutica, a delimitação do estudo envolve: [i] uma abordagem filosófica unificada pelo sistema crítico kantiano capaz de identificar os pressupostos que permita a realização dos julgamentos, [ii] o lugar do humano na comunidade e [iii] as possibilidades de uma orientação hermenêutica reflexionante. Como método, utilizou-se o dedutivo, considerando-se a orientação da pesquisa a partir de conceitos originalmente kantianos.
A GIG ECONOMY NO CURSO DA CRISE SANITÁRIA:AS RELAÇÕES DE TRABALHO NO CONTEXTO DAS PLATAFORMAS DIGITAIS
Authors: Figueiredo Ailene de Oliveira , Oliveira Lourival José de
Published: February 2022

O artigo tem como objetivo relacionar direito e economia e o emprego das ferramentas de tecnologias de acordo com o valor social do trabalho. Discutiu-se o papel do valor do trabalho no meio ambiente de trabalho tecnológico de execução, relacionando finalidade de custos de transação e lucro, e eficiência jurídica. Concluiu-se que a economia por meio das tecnologias disruptivas de trabalho humano, descumprem o vetor constitucional insculpido no artigo 170 da Constituição Federal. O trabalho foi realizado utilizando o método empírico-dialético, por meio de ferramentas de pesquisa bibliográfica utilizando-se do sistema de referência o Law and Economics por dados secundários.