bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of the hypothalamus in ghrelin effects on reproduction: sperm function and sexual behavior in male mice
Authors: Belén Poretti María , Bianconi Santiago , Luque Eugenia , Martini Ana Carolina , Vincenti Laura , Cantarelli Veronica , Torres Pedro , Ponzio Marina , Schiöth Helgi B , Carlini Valeria Paola
Published: November 2022

In brief

Ghrelin signals to the hypothalamus inhibit reproduction during times of food scarcity. In this study, we demonstrate that ghrelin impairs sperm quality in male mice.

Ghrelin (GHRL) is an orexigenic peptide that has been investigated as one of the signals responsible for the reproductive performance of mammals under fluctuating metabolic conditions. Central GHRL administration impairs spermatogenesis in mice by regulating the hypothalamic–pituitary–gonadal axis function. In the present study, the hypothalamus role as a mediator of GHRL effects on sperm fertilizing capacity and male sexual behavior was evaluated. After 42 days of hypothalamic GHRL infusion or artificial cerebrospinal fluid, in vitro and in vivo sperm fertilizing capacity, testicular α-tubulin, speriolin gene expression and spermatic α-tubulin protein were evaluated. Hypothalamic expression of genes Kiss1, Gpr54 and Gnrh was also studied. The second group of animals was infused with one time only GHRL or artificial cerebrospinal fluid into the hypothalamus to evaluate the effects on sexual behavior. Results demonstrated that chronic GHRL administration to male mice significantly increased the percentages of pre-implantation embryo loss and the number of post-implantation embryo loss. In relation to the gene expression, our results show a relative decrease of Kiss1, Gpr54 and Spatc1. Although no significant differences were observed in the quantitative expression of α-tubulin protein, qualitative changes in its expression pattern were observed. In addition, a dual effect on sexual behavior was observed: 40% of the treated animals showed a significant reduction in the number of mounts and intromissions, while a 60% showed a significant decrease in ejaculation latency vs control animals. In conclusion, our results provide evidence that central GHRL administration possibly induces failure in embryo development and/or implantation in the females mated with treated males, possibly because of a negative effect in the α-tubulin pattern.
Cardiovascular Risk Assessment and Management for Pediatricians
Authors: Schipper Henk S. , de Ferranti Sarah
Published: November 2022

Childhood and adolescence provide a unique window of opportunity to prevent atherosclerotic cardiovascular disease later in life, especially for pediatric groups at risk. The growing list of pediatric groups at risk includes individuals with chronic inflammatory disorders, organ transplants, familial hypercholesterolemia, endocrine disorders, childhood cancer, chronic kidney diseases, congenital heart diseases, and premature birth, as well as increasing numbers of children and adolescents with traditional risk factors such as obesity, hypertension, hyperlipidemia, and hyperglycemia. Here, we focus on recent advances in cardiovascular risk assessment and management and their implications for pediatric practice. First, hyperlipidemia and hyperglycemia are highly prevalent in the young, with hyperlipidemia occurring in 14.6% and hyperglycemia in 16.4% of children and adolescents with a normal weight. Implementation of nonfasting lipid and glycated hemoglobin screening in youth at risk is emerging as a promising avenue to improve testing compliance and lipid and glucose management. Second, blood pressure, lipid, and glucose management in youth at risk are reviewed in depth. Third, multisite and multimodal assessment of early atherosclerosis is discussed as a way to capture the complexity of atherosclerosis as a systemic disease. In addition to conventional carotid intima-media thickness measurements, the measurement of aortic pulse wave velocity and peripheral arterial tonometry can advance the assessment of early atherosclerosis in pediatrics. Finally, we make a plea for lifetime atherosclerotic cardiovascular disease risk stratification that integrates disease-associated risk factors and traditional risk factors and could facilitate tailored cardiovascular risk management in growing numbers of children and adolescents at risk.
Realia Education in Language Learning
Authors: Sinha Kajal
Published: November 2022

This paper aims to focus on the importance of Realia Education in language learning. As the world is getting globalized, it is utmost important to study various languages to communicate and connect with others. Learning new languages opens up a world of new opportunities for us. This
paper projects the efficient use of realia in the language learning process. Realia refers to the use of real life objects in the classroom to teach a particular concept or a language. It brings life to the class by improving the students' understanding to real life situations. It also aims
to highlight the benefits of using realia in the EFL classroom as it promotes a creative and engaging teaching-learning environment and brings up a cultural understanding. For English, the vocabulary learned from realia will provide a practical and interactive approach to learning. The chances
to remember the new words increases as it provides an interactive and practical approach.
 Realia based education is one of the ways to foster creativity and also makes the language learning more memorable and easier to recall . This study also discusses how realia connects the classroom
to the real world and makes the lessons interesting and relevant for the students. It enhances the concept retention capabilities and also provide a clear experience compared to any other method of language learning. It appeals to the learners of various age groups as it is quite relevant
and practical method for better understanding of a new language and is often more interesting than the material from text books. The use of physical elements allows a multidimensional learning experience to the students. Thus the ability to learn a new language improves if realia is included
in the learning process.
Impact of Film and Other Social Narratives on Students
Authors: Ghatak Debaleena
Published: November 2022

Nowadays films occupy a significant portion of the media products consumed by people. In Russia, cinema is being considered as a means of individual and social transformation, which makes a contribution to the formation of the Russian audience's outlook, including their attitudes towards
topical social issues. At the same time, the question of the effectiveness of films' impact remains an open question in psychological science. According to the empirical orientation of our approach to the study of mass media influence, our goal was to obtain new data on the positive impact
of films based on specific experimental research. The task was to identify changes in the attitudes of young people, as the most active viewers, towards topical social issues after watching a specifically selected film. Using a psychosomatic technique that included 25 scales designed to identify
attitudes towards elderly people, respondents evaluated their various characteristics before and after watching films. Using a number of characteristics related to the motivational, emotional and cognitive spheres, significant changes were revealed. At the same time, significant differences
were found in assessments of the elderly between undergraduate students and postgraduate students. After watching films, postgraduate students' attitudes towards elderly people changed in a positive way, while undergraduate students' negative assessments only worsened. The revealed opposite
trends can be explained by individual differences of respondents, which include age, educational status as an indicator of individual psychological characteristics, the experience of interaction with elderly people and, as a result, attitudes towards elderly people at the time before watching
movies. The finding that previous attitudes mediate the impact of the film complements the ideas of the contribution of individual differences to media effects. Most of the changes detected immediately after watching the movie did not remain over time. A single movie viewing did not have a
lasting effect on viewers' attitudes, and it suggests the further task of identifying mechanisms of the sustainability of changes.
Impact of Indian Cinema: Influence of Films on Students in Modern Times
Authors: Kumar Saranya , Sarkar Srijita
Published: November 2022

Films are one of the best means for provoking thoughts and ideas and engaging people to reflect on their actions and way of life. Films are therefore a prominent channel for student learning. Students take pleasure in watching films, imitating movie characters and grow fond of learning
languages and scientific concepts through them. Films are very commonly used as a tool for students learning in higher education and they have significant positive impacts. In the recent years, there has been a significant transformation of Indian cinema not just as a source of entertainment,
but, through portrayal of social and responsible cinema thereby having a stronger impact on the masses. Gradually the film fraternity is focussing on social issues and has created awareness amongst the students. However, the majority of the movie makers still have a backdated and stereotypical
film making mind-set which may have opposing effects. Various cultural transformations have happened over a point of time in India owing to the contributions made by contemporary movies and films. There have been changes with regards to the ideas of love and marriage, instances of live in
relationships have come of age and there has been a constant and continuous shift from the concept of joint families to nuclear families. Building on the changes in the cultural values; preferences have changed with regards to choice of career options, attitude, mental and physical health,
ethics and belief system. The research paper focuses on the holistic effects of Indian cinema on students and their behavioural changes as a bi-product of films . It aims to showcase the impact of changing genres and portrayal of students in Indian cinema amongst the youth and encourages the
film makers and media personnel to bring social issues on mainstream by implementing real aspects into the reel cinema.
Electronic properties of Cr and Dy co-doped ZnO: A first-principles study
Authors: Mukhopadhyay K. , Banerjee Priyanka
Published: November 2022

We have performed a systematical calculation for Cr and Dy co-doped ZnO by the first principles method using Quantum-Espresso. A lot of interesting results were found from the analysis of energy band structures and density of states. From spin-polarized calculations within the framework
of density functional theory, we have noticed that the value of total magnetization of co-doped ZnO is substantially enhanced compared to that of pure ZnO, and total magnetic moments mainly come from the contribution of Cr 3d and Dy 4f states. Our findings indicate that Cr and Dy co-doped
ZnO are capable magneto-electronic materials and they can be used for nanoscale spintronics device material.
Real-Time Heuristic Search in Dynamic Environments
Authors: Cheng Chao , Ruml Wheeler
Published: November 2022

In dynamic environments, agents often do not have time to find a complete plan to reach a goal state, but rather must act quickly under changing circumstances. Real-time heuristic search models this setting by requiring that the agent's next action must be selected within a prespecified time bound. In this paper, we study real-time search algorithms that can tolerate a dynamic environment, in which action costs are not fully predictable. We propose a combination of two previously-proposed methods and study its behavior both theoretically and empirically on several different benchmark domains.
Brigitte, a Bridge-Based Grid Path-Finder
Authors: Grastien Alban
Published: November 2022

We present BRIGITTE, a new path-finding algorithm for 8-connected grids. It is based on the notion bridge that we define here, i.e., a high-level description of paths between all pairs of points from two convex regions that allows fast distance query and fast generation of the prefix and suffix of these paths. BRIGITTE uses a pre-processing step to first partition the map into convex regions and then compute a sufficient set of bridges between every pair of regions. Path-finding is then performed by looking up the regions of the source and target cells and then iterating over the bridges of the pair of regions to determine which one yields the shortest path. BRIGITTE competes favourably compared to CH-SG-R and Copp, although this currently comes at a price of an extensive pre-processing.
A Case Study on the Importance of Low-Level Algorithmic Details in Domain-Independent Heuristics
Authors: Kuroiwa Ryo , Fukunaga Alex
Published: November 2022

It is known that seemingly small details such as tie-breaking among nodes with the same f-cost can significantly affect the performance of a best-first search algorithm on many domains (Asai and Fukunaga 2017). In this paper, we show that low-level algorithmic details of domain-independent planning heuristics can have a surprisingly large impact on search performance. As a case study, we consider the well-known FF heuristic (hff ) (Hoffmann and Nebel 2001).
Extended Abstract: Searching with Consistent Prioritization for Multi-Agent Path Finding
Authors: Ma Hang , Harabor Daniel , Stuckey Peter , Li Jiaoyang , Koenig Sven
Published: November 2022

We study prioritized planning for Multi-Agent Path Finding (MAPF). Existing prioritized MAPF algorithms depend on rule-of-thumb heuristics and random assignment to determine a fixed total priority ordering of all agents a priori. We instead explore the space of all possible partial priority orderings as part of a novel systematic and conflict-driven combinatorial search framework. In a variety of empirical comparisons, we demonstrate state-of-the-art solution qualities and success rates, often with similar runtimes to existing algorithms. We also develop new theoretical results that explore the limitations of prioritized planning, in terms of completeness and optimality, for the first time. This paper was published at AAAI 2019.
Algorithms for Average Regret Minimization
Authors: Storandt Sabine , Funke Stefan
Published: November 2022

In this paper, we study a problem from the realm of multi-criteria decision making in which the goal is to select from a given set S of d-dimensional objects a minimum sized subset S' with bounded regret. Thereby, regret measures the unhappiness of users which would like to select their favorite object from set S but now can only select their favorite object from the subset S'. Previous work focused on bounding the maximum regret which is determined by the most unhappy user. We propose to consider the average regret instead which is determined by the sum of (un)happiness of all possible users. We show that this regret measure comes with desirable properties as supermodularity which allows to construct approximation algorithms. Furthermore, we introduce the regret minimizing permutation problem and discuss extensions of our algorithms to the recently proposed k-regret measure. Our theoretical results are accompanied with experiments on a variety of inputs with d up to 7.
Intuitive, Reliable Plans with Contingencies: Planning with Safety Nets for Landmark-Based Routing
Authors: Alwala Kalyan , Safonova Margarita , Salzman Oren , Likhachev Maxim
Published: November 2022

We are interested in the problem of providing intuitive instructions for human agents to enable reliable navigation in unknown environments. Since the advent of GPS and digital maps, a common approach is to visually provide a planned path on a digital map defined in terms of actions to take at specific junctions. However, this approach relies on the agent to constantly and accurately localize itself. Furthermore, it comes in stark contrast to the way humans provide instructions—by leveraging known landmarks in the environment to both augment the description of the planned path as well as to allow to detect when the agent deviated from the planned path. Hence, there is need for assurable means of localization, an intuitive way of compactly conveying directions to agents and a systematic approach to account for human errors. To this end, our key insight is to employ known landmarks in the environment to overcome these challenges. We formally model this intuitive way to use landmarks for conveying instructions and for creating contingency plans. We present experiments demonstrating the efficacy of our approach both on synthetic environments as well as on realworld maps, computed using a smart-phone iOS application that we developed.
Revisiting Suboptimal Search
Authors: Chen Jingwei , Sturtevant Nathan , Doyle William , Ruml Wheeler
Published: November 2022

Suboptimal search algorithms can often solve much larger problems than optimal search algorithms, and thus have broad practical use. This paper returns to early algorithms like WA*, A*_e and Optimistic search. It studies the commonalities between these approaches in order to build a new bounded-suboptimal algorithm. Combined with recent research on avoiding node re-expansions in bounded-optimal search, a new solution quality bound is developed, which often provides proof of the solution bound much earlier during the search. Put together, these ideas provide a new state-of-the-art in bounded-optimal search.
Learning and Utilizing Interaction Patterns among Neighborhood-Based Heuristics
Authors: Chuang Chung-Yao , Smith Stephen
Published: November 2022

This paper proposes a method for learning and utilizing potentially useful interaction patterns among neighborhood-based heuristics. It is built upon a previously proposed framework designed for facilitating the task of combining multiple neighborhood-based heuristics. Basically, an algorithm derived from this framework will operate by chaining the heuristics in a pipelined fashion. Conceptually, we can view this framework as an algorithmic template that contains two user-defined components: 1) the policy H for selecting heuristics, and 2) the policy L for choosing the length of the pipeline that chains the selected heuristics. In this paper, we will develop a method that automatically derives a policy H by analyzing the experience collected from running a baseline algorithm. This analysis will distill potentially useful patterns of interactions among heuristics, and give an estimate for the frequency of using each pattern. The empirical results on three problem domains show the effectiveness of the proposed approach.
Functional Status of Patients on Maintenance Haemodialysis and Burden of Their Caregivers: An Example from a Tertiary Referenz Hospital in Cameroon
Authors: HM Patrice , T Loic , E Christian , N Vincent , M Mahamat , M Junette , F Hermine , KF Francois
Published: November 2022

Background: Patients on maintenance hemodialysis (MHD) often depend on caregivers due functional status impairment (FSI). We evaluated the functional status of patients on MHD and the burden on their caregivers in Douala. Material and methods: A fourth month cross-sectional study including consenting adult patients on MHD in Douala general hospital and their caregivers. Functional status of patients was assessed using the overall functional status scale. A FSI score between 1-5/13 was considered moderate, and severe when above 5/13. Caregiver burden was assessed with the Zarit caregiver burden scale; a score between 21 to 40 was considered light to moderate burden, and severe if >41. Logistic regression was used to look for associated factors to FSI and caregivers burden (p <0.05). Results: In 184 patients, the mean age 47.29 (13.75) years. FSI was moderate in 60.33% (111/184) and severe in 8.69% (16/184). Caregiver burden was light to moderate in 48.91% (90/184), severe in 38.59% (71/184). Factors associated with FSI were: older patients, low patient and caregiver income, diabetes, longer duration on dialysis and being accompanied by his child. Factors associated with caregiver burden were: male gender, patient’s age ≥ 70 years, low patient’s income, inability to do shopping and laundry, age of caregiver ≥ 50 years, and caregiver being a student. Patient functional dependence increased the caregiver’s burden by 3.87 times (p=0.001). Conclusion: FSI and caregiver’s burden were relatively high with many associated factors. The caregiver burden increased with the degree of patient dependence.
Educational management policy evaluation model in institutions
Authors: Salazar Vega Edelma Eusebia , Rojas Luján Víctor William
Published: November 2022

The objective of the research is to propose a theoretical-methodological model with a participatory approach and specific references to evaluate educational policies in educational institutions of theLocal Educational Management Unit, Sánchez Carrión, Huamachuco, 2020. Methodology: Basic type research, descriptive design, with sample of 66 teachers, evaluated through the Educational Management Policy Evaluation questionnaire consisting of 16 items. Results: Most directors do not have knowledge about educational management policies (questions1, 2 and 3), the institution does not have an evaluation model (question 9), goals have been implemented (question 6), most evaluate the achievements (question 10), and evaluate the coverage of the service provided (question 13), that the evaluation serves to improve the management of the EI (question 14), mostly parents participate in the institutional evaluation (questions 15 and 16). Conclusion: The majority of teachers did not present knowledge about the educational management policies in the educational institutions of JEC-UGEL Sánchez Carrión, Huamachuco, 2020.
Beyond the technical: the true face of territorial organisation
Authors: Guevara Cuñe Melyna del Pilar , Rodríguez Albán Segundo Miguel
Published: November 2022

Throughout history, the territorial structure of the Peruvian State has been shaped, which has undergone a sharp break between what existed in the Incanato and the implantation of a new colonial territorial system, leading to an irrational division of the territory and lack of boundaries today.The general objective of this article was to identify the main factor that conditions the process of territorial organization.The cardinal strategy employed for the development of the research is qualitative methodology, at the descriptive level, and its rigour lies in the relevance that the topic prevails within the framework of territorial development.It is based on the case study method, with the Trujillo province, belonging to the La Libertad region, as the unitof analysis.Finally, it was concluded that the limitations during the process of territorial organization converge in an essentially “political” scenario, which constitutes the main factor conditioning the process of territorial organization.
The Canvas model studied the impact factor and its visualization in the EBSCO database, Scopus, Scielo, 2017 -2021
Authors: Abanto Merino Luis Alfredo , Márquez Yauri Heyner Yuliano
Published: November 2022

This manuscript is based on a bibliographic review that supports the research with concepts and definitions from different authors. The idea is to document different aspects of theresearch, the objective of this study is to know the field of science, engineering, arts, medicine, course management and/or business in general, the Canvas business model is It applies to any field. More specifically, this study aims to answer the following question: How much is the Canvas business model applied by business sector in jobs published between 2017 and 2021? The method used consisted of compiling and reviewing scientific publications filtered from databases, particularly EBSCO, Scopus and Scielo, using keywords related to the titles of the books. The result of the selected documents was 76, made up of 209 authors, leaving 71 documents in a state of debugging, the results of which will appear in various tables and figures. In conclusion, the author argues that the business model is a tool that can be used in different fields because it is a simple and flexible method that hopes to solve problems, deals with opportunities and demands, because it is very active and creative.
The Importance of Version Control Systems in Web Systems Release Management
Authors: Angeles Piedra Nelson , Azabache Santos Jose , Mendoza De los Santos Alberto
Published: November 2022

En la actualidad el manejo y disponibilidad de los softwares son muy demandados, han demostrado grandes resultados frente a los sistemas tradicionales para las organizaciones, quienes buscan gestionar su versionamiento para mejorar la calidad de sus servicios. El presente artículo planteócomo objetivo determinar el efecto que causan los sistemas de control de versiones en la gestión de liberación de los servicios web. Para lo cual el presente artículo realizo una revisión sistemática de la información comprendida entre los años 2018 y 2022 para focalizar su importancia. Obteniendo como resultados que las diferentes empresas ya alojan sus servicios en un repositorio de control de versiones como GitHub, BitBucket, GitLab, entre otros; ayudando a los sistemas a tener un mejor control de futuras versiones y liberación, e incluso de poder tener un respaldo de estas versiones que se van dejando atrás en todo el ciclo de vida de un proyecto.
Evaluation of effects of Forsus Fatigue Resistance device in correction of class II division 1 malocclusion in adolescent patient: A case report
Authors: Anupama V Jain , Anand K Patil , Roopak Naik
Published: November 2022

Introduction: Class II malocclusion is one of the most prevalent malocclusions. The Class II malocclusions are caused due to forwardly placed maxilla, the backward position of the mandible, or a combination of both these factors. This disparity in skeletal base growth and position can be corrected during growth spurts using functional and fixed functional appliances. Description: An adolescent boy with Class II division 1 malocclusion, retrusive mandible, and increased overjet was treated with a pre-adjusted edgewise appliance (0.022-slot Gemini 3M -MBT prescription) along with a fixed functional appliance, Forsus TM Fatigue Resistant Device. The Skeletal age of the patient assessment using Hand wrist radiograph and CVM showed a major part of the adolescent growth spurt to be completed. Pre-treatment and post-functional cephalograms were traced and superimposed to compare changes in the skeletal base and dental structures. Result: The Class II molar and canine relationships were corrected to class I and the mandible showed forward positioning leading to correction for the skeletal base to class I. The facial profile showed marked improvement to an orthognathic pleasing profile. Conclusion: The purpose of this case report is to emphasize on use of fixed functional appliances in the treatment of adolescents with skeletal base discrepancies like Class II division 1 malocclusion. Intervention with fixed functional appliances at the appropriate skeletal age can prevent the need for extractions or other surgical procedures that may be needed to correct the malocclusion.
Regional Experience in Organizing and Holding a Competition of Professional Skills “Teacher-Psychologist” in the Sverdlovsk Region
Authors: Vasyagina N.N. , Shempeleva N.I. , Bulatova N.A.
Published: November 2022

The article is aimed at describing the professional skill contest “Teacher-Psychologist” as one of the effective mechanisms for stimulating and supporting the professional development of the personnel potential of the psychological service in the education of the Sverdlovsk region. The paper pays attention to the peculiarities of the organization and conduct of the competition in the region, considers changes in the content of competitive tests, which vary in accordance with modern trends in the development of psychological science and psychological and pedagogical services in the education system and the specifics of the region. The analysis of the eight-year experience of the Teacher-Psychologist competition in the Sverdlovsk region allows us to note positive trends in the change of motivation and the level of professional competence of teachers-psychologists, which are reflected in the high performance of specialists of the Sverdlovsk region at the federal stage of the competition. Of great importance in achieving such high results is the training of contestants in the region, which is organized in the form of teamwork involving participants and winners of the federal stage of the competition, and is conducted under the guidance of the Chief Freelance Psychologist of the Sverdlovsk region, which ensures the success of the presentation of professional skills by the contestants.
The Use of the “World Café” Technology by a Teacher-Psychologist in Order to Study Joint Activities and Group Behavior
Authors: Matveeva A.V.
Published: November 2022

The large number of psychological studies on the problem of joint activity have been carried out a in our country over the past 40 years made a certain contribution to the formation of the corresponding concept, which has become one of the most common in the psychology of groups and collectives, especially labor collectives. This problem was formulated differently not only in different periods of its development, but also by different researchers. Despite some differences in the formulations of the problem, as well as changes as a result of its natural development, the problem of joint activity is still it remains in the focus of attention of researchers. Recently, specialists have distinguished a special type of joint activity — jointly creative. This type of organization of collective activity originated in the fields of science and art. The laws of creativity require taking into account everyone, even the most “crazy” vision, because in the cauldron of general discussion, a discovery can appear from the most absurd idea. This type is characterized by a special activity of each of the participants in the interaction process, namely: activity in terms of improving their own professional competence through participation in collective activities. The World Cafe as a way of group discussion in a relaxed and relaxed atmosphere may be successfully implemented in the practice of a teacher-psychologist.
Communication Skills and Empathy of First-Year Students
Authors: Sunko T.Y.
Published: November 2022

The work is aimed at determining differences in the distribution of first-year students by levels of empathy in relation to communicative skills, since in the process of developing personal professional qualities in the process of preparing for educational and professional communication, communicative skills and empathy also become relevant. A brief theoretical review of research on communicative skills and emotional experiences as components of personal professional qualities is presented. The results of a mixed empirical study were obtained on a normal sample of defectology students (A<1; E<1). The study involved respondents (N=49) aged 17 to 23 years (M=19,20; SD=1,51). The methods of L. Mikhelson “Test of communicative skills”, A. Mehrabyan and N. Epstein “Diagnostics of the level of polycommunicative empathy” were used as a research tool. The research procedure was carried out through a voluntary online questionnaire. The results indicate the severity of very high and high levels of polycommunicative empathy and competence-based type of communicative behavior in the process of teaching students-defectologists. Intergroup differences in the distribution of respondents with competence-based, dependent and aggressive types of communicative behavior in the process of preparing for educational and professional communication were obtained. It is noted that the manifestation of the competence type of communicative behavior (71,4%) in educational and professional communication and very high (53,1%), high levels (42,9%) of polycommunicative empathy allow us to assert individual differences in the formation of personal professional qualities of students. The empirical data obtained are presented in the light of the communicative-activity approach and explain the statistical differences in the levels of empathy of students in relation to various types of communicative behavior.
Kurdish Language Sentiment Analysis: Problems and Challenges
Authors: Omar Al-Rassam, Zhenar Shaho Faeq Miran Hama Saeed Mohammed Amin,
Published: November 2022

The increasing usage of blogs, social networks, and forums for sharing opinions on a certain topic has created vast amounts of internet data. Therefore, Sentiment Analysis has gained great popularity among researchers and industry for analyzing the polarity of users' opinions. In recent years, Sentiment Analysis has been applied to various languages using machine learning-approach, corpus-based approach, and deep learning techniques since it is beneficial for creating an effective recommender system. The Kurdish Language is an Indo-European language, one of the official languages in Iraq, and it is also widely used in Turkey, Iran, and Syria. Although the importance of this Language is spoken by over 40 million people, to the best of our knowledge, no research has been done regarding the challenges and problems of Kurdish sentiment analysis. Our research aims to highlight the latest studies and examine the most critical challenges of applying sentiment analysis approaches to the Kurdish Language. The study includes determining each challenge in each step of sentiment analysis processing in the Kurdish Language. In addition, our proposed methodology that could help address most of these challenges is implementing a hybrid approach by combining machine learning and lexicon-based approaches to improve the proficiency of sentiment classification in the Kurdish Language.
TÜRKİYE'DE DIŞ TİCARETİN EKONOMİK BÜYÜME ÜZERİNDEKİ ETKİSİNİN AMPİRİK ANALİZİ
Authors: YILMAZ Ömer , ALBAYRAK Muzaffer
Published: November 2022

Uluslararası ticaret, büyüyen ekonomilerde önemli bir faktördür. İhracat ve ithalat, uluslararası ticaretin en önemli bileşenleridir. Ülkeler, ekonomik büyümeyi ve refahı artırmak için ihracatı artırmaya ve ithalatı azaltmaya çalışır. Türkiye 1980 yılından itibaren açık bir ekonomik modeli tercih etmiş ve ekonomi politikalarını değiştirmiştir. Bu çalışma, ihracat ve ithalatın büyüme üzerindeki etkisini belirlemeye yöneliktir. ARDL sınır testi yaklaşımı kullanılarak analiz yapılmadan önce, serilerin birim kökü incelenmiş ve birinci farkta durağan ve yapısal değişikliklere duyarlı olduğu bulunmuştur. Ampirik kanıtlar, ithalat ve ihracat ile ekonomik büyüme arasında uzun dönemli bir ilişki olduğunu göstermektedir. Sonuçlar, ihracatın ekonomik büyüme üzerindeki etkisinin kısa ve uzun vadede negatif olduğunu göstermektedir. Başka bir deyişle, ihracattaki artış ekonomik büyüme için zararlıdır. Öte yandan, ithalatın ekonomik büyüme üzerindeki etkisi pozitiftir. Bu durum, Türkiye'nin dış ticaret politikasını yeniden gözden geçirmesi ve yeni stratejiler geliştirmesi gerektiğini göstermektedir. Hedefler doğrultusunda katma değeri yüksek ürünlerin teşvik edilmesi ve üretilmesine önem verilmesi ile kalkınma ve refahın ilerlemesinde önemli ilerlemeler sağlanabilir.
Exploring the Factors challenging Virtual Internships during the COVID-19 Pandemic: An insight on students’ perspective in the United Arab Emirates universities
Authors: Shishakly Rima
Published: November 2022

The COVID-19 pandemic health restriction for almost two academic years brought considerable conditions to higher education learning methods and shifted to e-learning. Internships course is one of the courses where University students are obliged to shift the course attendance and accomplishment to be virtually or remotely. It still limited study about the factors that influence virtual internships conduction. The study aims to explore from students' perspectives the factors that influence virtual internships' conduction and their impact on students' academic achievement. A total of 214 surveys were distributed to university students in the United Arab Emirates who attended virtual internships during the COVID-19 pandemic. The study reveals that internships' flexibility, knowledge, quality, and collaboration are factors that significantly influence students' academic achievement in internships/training courses during the COVID-19 pandemic.
Severe Psychological Distress Among Medical Students During the COVID-19 Pandemic: Toward a Safer Mental Health
Authors: Essangri Hajar , Bahaoui Nezha , Benkabbou Amine , Majbar Mohammed , Lekehal Brahim , Mohsine Raouf , Souadka Amine
Published: November 2022

Objective: As we learn how to live with the COVID pandemic, understanding this psychological impact of the coronavirus outbreak and its determinants is the first step towards finding solutions. The aim of the study is to examine the status of medical students' mental health and assess psychological distress determinants and pathways in order to suggest adapted strategies to help them. Methods: We performed a convergent parallel mixed-methods analysis of an online survey administered to medical students from March 23 to March 28, 2020. Psychological distress was assessed through the Kessler 6 (K6) questionnaire. Factors associated with severe psychological distress (SPD, K6>13) were identified by multivariable logistic regression. The qualitative part analyzed responses to open-ended questions addressing medical students' perspectives on the impact of the pandemic and relieving factors. Results: 808 medical students completed the survey. Severe psychological distress was reported by 234(28.96%) respondents and was independently associated with: Female sex (OR,2.8;[ 95%CI ,1.791-4.363];P<0.001), clinical study level (OR,0.621;[95%CI,0.437-0.881];P =0.008), Tobacco use (OR, 3.664;[95% CI,1.9 - 7.07];P =0.001), history of psychiatric meds (OR, 2.454 ;[95%CI,1.384 - 4.454];P=0.001) and quarantine (OR, 1.5 ;[95%CI, 1.015 - 2.337];P =0.04). Students submitted a total of 2424 concerns about ways the pandemic affected different areas of their lives and redundants determinants were summarized. Conclusion: During the COVID crisis, 28% of our students experienced severe mental distress due to multifactorial determinants including social and individual psychological and behavioral contributors. This crisis is an opportunity to address the well known mental health morbidities of future physicians and increase the awareness about the important role that medical schools could have as a safety net and support system. Keywords: COVID-19, Medical student, Mental health, Psychological distress, lifting lockdown measures
Bone Anchored Hearing Aid (BAHA®) Implant in Canal Atresia and Microtia: A Single Case Report
Authors: Tarmizi Nur , Abdullah Asma , Naseri Fahrin
Published: November 2022

Bone anchored hearing aid (BAHA®) implant is a type of hearing rehabilitation for patients with conductive, mixed or unilateral hearing loss. There are various options for BAHA® usage. Two of the most used bone-anchored hearing implant systems are the BAHA® Connect and BAHA® Attract. The BAHA® Connect uses a skin-penetrating titanium abutment. The BAHA® Attract uses an implanted magnet, leaving the overlying skin intact. This case report highlights the particular benefits of BAHA® Attract System in a patient who had previously worn the BAHA® Connect System. It was upgraded to the Attract System following post-surgical infection. The patient showed improved compliance, and thus has a better hearing outcome. BAHA® Attract system gives its patient better compliance and ease of use along with its reduced complications.
The Transactivation of the Erbb Family of Receptor Tyrosine Kinases Is Regulated by Neurotensin Receptors in Cancer
Authors: Moody Terry
Published: November 2022

Neurotensin (NTS)-like peptides are autocrine growth factors for lung cancer. NTS is present in and secreted from lung cancer cells and binds to G protein-coupled receptors causing signal transduction and proliferation. The growth of non-small cell lung cancer (NSCLC) cells is stimulated by NTS and inhibited by SR48692, a small molecule NTSR1 antagonist. Adding NTS to NSCLC cells increases the tyrosine phosphorylation of ErbB receptor tyrosine kinases EGFR, HER2, and HER3 by transactivation. The NTSR1 regulation of EGFR, HER2, and HER3 transactivation is blocked by SR48692, specific tyrosine kinase inhibitors, and certain monoclonal antibodies. Additional agents which impair the transactivation process include PP2 (Src inhibitor), GM6001 (matrix metalloprotease inhibitor), and N-acetyl-cysteine (antioxidant). The results indicate growth stimulation caused by the adding NTS to NSCLC cells may be mediated by transactivation of ErbB RTKs.
Spatial diffusion of Omicron in Texas: Predictable or Random?
Authors: Jones Richard
Published: November 2022

The impacts of Covid-19 on society and the environment have now, three years from its first appearance, ballooned across the scientific literature. But our knowledge of where it originated, and why it spread as it did, has advanced much more slowly. Models of spatial diffusion at national level have been applied to past pandemics with some success, but not yet to Covid-19. One exception is a study of the spread of the original strain of Covid-19 in Texas between March and September 2020. This spread adhered to spatial diffusion theory: first hierarchical, that is into metropolitan areas in proportion to their population sizes; later contagious, that is into adjacent towns based on their proximity to metropolitan areas to which they were tributary; and finally hierarchical once more, into the most isolated towns based on their urban/ rural status. This process took six months. By contrast, the Omicron variant, in less than two months (December 2021 and January 2022), reached case levels three times those of the original Covid surges. The current study focuses on how Omicron diffused across Texas over the period November to February 2021-22. Daily case numbers for Covid-19 were available for all 254 counties from the Texas Department of State Health Services over this period, and the Omicron variant was identifiable from these data. This analysis will reveal whether the Omicron spread across the counties of Texas was predictable, partially predictable, or unpredictable, based on county population, distance to their regional metro, or the gravity concept (the ratio between the two). These insights will be of value if other such variants appear on the horizon for the US and Texas, enabling local health officials to anticipate the onset in their communities.
A Survey on Digital Epidemiology: Networks and Models
Authors: Pastor-Escuredo David , Olmos Luis
Published: November 2022

The epidemiology has recently witnessed great advances based on computational models. Its scope and impact are getting wider thanks to the new data sources feeding analytical frameworks and models. Besides traditional variables considered in epidemiology, large-scale social patterns can be now integrated in real time with multi-source data bridging the gap between different scales. In a hyper-connected world, models and analysis of interactions and social behaviors are key to understand and stop outbreaks. Big Data along with apps are enabling for validating and refining models with real world data at scale, as well as new applications and frameworks to map and track diseases in real time or optimize the necessary resources and interventions such as testing and vaccination strategies. Digital epidemiology is positioning itself as a discipline necessary to control epidemics and implement actionable protocols and policies. In this review we address the research areas configuring current digital epidemiology: transmission and propagation models and descriptions based on human networks and contact tracing, mobility analysis and spatio-temporal propagation of infectious diseases and infodemics that comprises the study of information and knowledge propagation. Digital epidemiology has the potential to create new operational mechanisms for prevention and mitigation, monitoring of the evolution of epidemics, assessing their impact and evaluating the pharmaceutical and non-pharmaceutical measures to fight the outbreaks. Epidemics have to be approached from the lens of complexity science as they require systemic solutions. Opportunities and challenges to tackle epidemics more effectively and with a human-centered vision are discussed here.
Clinical Utility of Multigene Assays for Guiding Treatment Decisions in Early Breast Cancer Patients
Authors: Markopoulos Christos
Published: November 2022

The clinical management of invasive breast cancer has changed during the last decade with the use of molecular-based multigene assays (MGAs).They are increasingly used to gain additional prognostic and predictive information and guide adjuvant treatment decisions. Since 2004, several MGAs have become available but, four of them are the most widely used in clinical practice: the OncotypeDX® Breast Recurrence Score, the 70-gene signature MammaPrint®, the Prosigna® (PAM50) and the EndoPredict® (EP/EPclin Scores) assay. However, MGAs are not all the same and they do not provide interchangeable information. They differ in terms of the technological platform used for their development, the number and specific genes assessed, and the patient populations in which they were validated. Furthermore, although they are all validated for providing prognostic information, not all of them are supported with data from prospective randomised trials confirming the clinical value of their use in chemotherapy treatment decisions in certain groups of breast cancer patients; in this regard, so far there are published data only for OncotypeDX and MammaPrint, whilst PAM-50 (Prosigna) and EndoPredict assays are currently not supported by entirely prospective randomized trials evaluating their predictive value of chemotherapy benefit. As such, inclusion of these MGAs in major international treatment guidelines differs in indications for their use in clinical practice as prognosticators only or as predictors of chemotherapy benefit as well. Use of MGAs in clinical decision making can lead to de-escalation of chemotherapy recommendations and thus save a large number of patients from unnecessary side effects and decrease the cost of breast cancer treatment to National Health systems. This review provides an overview of the four most widely used MGAs in clinical practice, including basic information on their development and validation, as well as recent data on the information they can provide.