bluuebunny/crossref_metadata_2025 huggingface dataset:
Necrotic Enterocolitis: Clinical and Anamnestic Parallels in Premature Infants.
Authors: Vlasova Olena Vasylivna , Hrytsiuk Mariana Ivanivna , Kolyubakina Larisa Viktorovna , Homma Natalia Vasylivna
Published: February 2021

Necrotic enterocolitis (NEC) in neonatal practice remains one of the major causes of morbidity and mortality in premature infants due to the combined effect of various pathogenic factors: infectious, metabolic, circulatory on the relatively immature bowel. Most often the onset of the disease occurs at the gestational age of the baby 29-32 weeks at the age of 2-3 weeks of life.Objective of study: evaluation of anamnestic, clinical and paraclinical data and course of NEC in premature infants who were hospitalized in the neonatal unit of Regional Children's Clinical Hospital (RCCH) of Chernivtsi.Materials and methods. A retrospective analysis of the diseases of 28 premature infants who were hospitalized in the neonatal intensive care unit (NICU) of RCCH was performed. While in the hospital, all children underwent general clinical, biochemical, instrumental methods of investigation and determination of immunological parameters of the infectious-inflammatory process in the blood serum, namely the level of C-reactive protein and pressepsin was made.Results. Among the examined, the proportion of deeply premature infants (up to 32 weeks of gestation) was 50%, including extremely low weight 17.8%. About 80% of children were born with signs of asphyxia of varying severity. It was shown that the development of NEC in premature children is associated with a burdened infectious history in mothers amid anemia (r = + 0.79), a short gestation period (r = + 0.44), and a low Apgar score in the fifth minute (r = + 0.45), the severity of the condition at  admission to the hospital (r = + 0.74), the need for long-term mechanical ventilation (r = + 0.67), hemodynamic support with the vasoactive drugs (r = + 0.39), apnea development (r = + 0.83), feeding intolerance (r = + 0.45) and thrombocytopenia (r = +0.68). It was established that the determination of serum presepsin content makes it possible to verify the genesis of the development of NEC.Conclusion. The formation of NEC in premature infants is associated with the development of multiple organ failure in the anamnesis due to asphyxia, and its chances are increased due to the presence of a generalized infectious inflammatory process.
The effectiveness of the application of nanomaterial polymer technologies in a comprehensive approach to surgical treatment of soft tissue wounds
Authors: Popadyuk Oleg , Plehutsa Oleksandr
Published: February 2021

Treatment of purulent wounds remains one of the most important problems of surgery, both theoretically and practically. The aim was to study the effect of biodegradable polymer film "biodep-nano" and hydrated fullerene C60 on the healing of soft tissue wounds and prevention of their infection. We observed 124 patients with purulent-inflammatory soft tissue complications. Scientific group 53 (42.7%) patients who, in addition to complex treatment, performed the proposed therapy. The control group consisted of 71 (57.2%) patients who were treated according to conventional methods. The results showed that the temperature of the study area in the main group returned to normal on the 3rd day (2.8 ± 0.2 days), and in the group where traditionally used wipes on the 5-7th (5.9 ± 0, 4) the day where (p <0.05). Note that the average time of postoperative wound cleansing in patients of the control group was 14.1 ± 0.8 days, the appearance of granulation tissue - 15.6 ± 0.9 days, and the beginning of the marginal epithelialization - 18.4 ± 1.0 days The length of stay of patients in this group on an inpatient bed was 34.3 ± 2.8 days. Thus, from a surgical point of view, a new promising alternative is a combination of surgical treatment of wounds and the use of nano-containing biodegradable polymeric material, which not only destroys pathogenic wound flora, but also can prevent re-infection and purulent-inflammatory recurrence.
Use of modern information and communication technologies in the process of preparation of future bachelors of motor transport
Authors: Hevko Ihor Vasilievich , Franko Yuri Pavlovich
Published: February 2021

The importance of application of modern information technologies in the educational process of training future bachelors of road transport is outlined. It has been found that the use of computer tools makes the learning process more technological and effective. The focus is on the introduction of elements of computer-aided design in the educational process.
Symptom correlations of organic brain impairment and psychopathology in patients with residual schizophrenia
Authors: Safonov D. N.
Published: February 2021

Relevance. Organic brain impairment (OBI) is one of the most well studied comorbid pathology to schizophrenia. Nevertheless it is not clear yet, how it influences some structural and dynamic aspects of main pathology, such as positive symptoms variability and intensity or negative symptoms progression.Aim – to analyze influence of most common types of organic brain impairment and intensity of residual schizophrenia symptoms. Materials and methods. A study was performed on 100 case histories of patients of Zaporozhye Regional Clinical Psychiatric Hospital who were treated as inpatients with diagnosis of recurrent schizophrenia (ICD-10:F20.5) in time period from 2010 to 2020. Results. On the first stage of a study we studied contingent’s medical history focusing on probable organic brain impairment inducing factors: cerebrovascular catastrophes, cerebrovascular diseases and cerebrovascular conditions.  We gathered clinical data on intensity of main positive and negative recurrent schizophrenia symptoms. Among positive symptoms rating in study contingent only conceptual disorganization reaches moderate level of intensity. Negative symptoms among studied patients have higher average intensity than positive with evenly moderate levels with exceptions of difficulty in abstract thinking and stereotyped thinking. We analyzed correlations between organic brain impairment inducing factors and positive and negative syndromes scale categories intensity rating. For correlation statistical interpretation we used Chaddock scale. Only weak correlations were found between positive symptom ratings and OBI inducing factors correlations both positive and negative. For negative symptom ratings we have found all weak correlations but one (traumatic brain injury have moderate negative correlation with conceptual disorganization). Conclusions. Analysis of correlations between organic brain impairment inducing factors with positive and negative symptoms revealed controversial data but definitely demonstrated presence of weak up to moderate influence of organic brain impairment on positive and negative symptom intensity.  However this influence is both positive and negative according to specific symptom as well as specific organic brain impairment variant.
The value of the expression of endometrial receptors for steroid hormones in patients with endometriosis
Authors: Pedachenko N. Yu. , Shemelko T. L. , Tukhtarian R. A.
Published: February 2021

Aim: To elucidate the nature of the expression of progesterone receptors (PR) and estrogen receptors (ER) of the endometrium in patients with endometriosis in order to study the effect of endometriosis therapy on endometrial receptors while taking progestogens and agonists of gonadotropin-releasing hormones (a-GnRH).Materials and Methods. A total of 119 women were examined, including 69 patients with small-sized endometrioma with adenomyosis, who were divided into two subgroups during the study: 35 women received Dienogest therapy, other 34 patients received Diferelin. To study the expression of endometrial steroid receptors, the patients underwent endometrial aspiration biopsy from different points of the uterine cavity before the treatment and after 3 months against the background of the therapy for endometriosis.ResultsEndometriosis therapy affects the expression pattern of endometrial steroid receptors. While taking Dienogest, the sensitivity of the endometrium to estrogens increases, and the number of cells with a positive response to progesterone receptors is partially reduced. When using gonadotropin-releasing hormone agonists (Dipherelin), the sensitivity of the uterine mucosa to ovarian hormones decreases, which is confirmed by the adequate expression of ER and PR. There is a need for more research on estrogen beta receptors, as well as progesterone receptors A and B, and the related ratios.
Cytogenetic study of buccal epitelium in patients with neonetal sepsis, whose parents lived permanently in different environmental conditions
Authors: Vlasova Olena Vasylivna
Published: February 2021

The micronucleus test is a generally accepted and available method for the cytogenetic assessment of the mutagenic effect of factors of various natures. Currently, this test is one of the non-invasive methods of surveying the population that are under the influence of environmental pollution.Purpose of the study: to determine the features of the karyological indicators of the buccal epithelium in children with neonatal sepsis, whose parents lived permanently in different environmental conditions.Material and methods. To achieve this goal, a comprehensive survey of 260 newborns suffering neonatal sepsis in 2016-2018 was carried out. The group-forming feature of a comprehensive assessment of the long-term burden on the body of newborns’ parents in anthropogenic pollution of air, water and soil in the areas of the region became the proposed coefficient of ecological risk (CER) taking into account the environmental situation in regional centers.Thus, the first clinical group (main) included patients with neonatal sepsis, whose parents lived permanently in places with CER 2.0 and more and with unfavorable environmental characteristics of the regional center. The second group (comparison) was formed by newborns with sepsis, whose parents lived permanently in areas with a low risk of adverse effects of these environmental factors on their body (CER < 2.0). Micronuclear test of exfoliative buccal epithelium in patients with neonatal sepsis was performed and evaluated in the immunological laboratory of the Department of Pediatrics and Pediatric Infectious Diseases of BSMU according to the method of Kalaeva V.N.Results and discussion. In the main group, the proportion of children with a high risk of cytogenetic disorders significantly prevailed with a slight decrease in the quota of patients with a low risk. So, in group I with a low risk of cytogenetic disorders there were 42.1% of cases, with an average risk of -5.3%, and with a high risk of -52.7% of cases. In the comparison group, there were 54.5%, respectively, with a low risk of cytogenetic disorders, (P> 0.05) cases, with an average risk -12.1%, (P> 0.05), and with a high risk -33.3% , (P = 0.05) cases.Conclusions. The results of the karyological test of the exfoliatic buccal epithelium make it possible to note that cytogenetic disorders and, in some cases, disorders in cell kinetics in the form of proliferation and apoptosis were found significantly more often in the newborns of the main group compared with children in the comparison group. The index of accumulation of cytogenetic disorders was also significantly higher in patients of group I due to the predominance of patients with a high risk of cytogenetic disorders.
Implementation of technology for the formation of information and communication competence among future choreographers
Authors: Avramenko Olena , Humeniuk Serhii
Published: February 2021

The article is devoted to one of the current problems in vocational education – the formation of future choreographers information and communication competence (ICC). The author defines the essence of the concept of "information and communication competence". The article emphasizes that the result of the formation of choreographers information and communication competence in the learning process is the formed competence for this type of activity. When substantiating and developing the technology, the following stages of its implementation are distinguished: motivational, cognitive and technological. All three stages of the developed technology are aimed at the formation of future choreographers of information and communication competence. In the process of professional training of future choreographers for professional activity by means of information and communication technologies the criteria (motivational, semantic, reflective) and levels of formation (high, average, low) are specified. 128 respondents of the first and second courses of the Faculty of Arts of theG.S.SkovorodaKharkivNationalPedagogicalUniversitytook part in the pedagogical research (by consent). The control group consisted of 66 people (CG), and the experimental group – 62 people (EG). The article describes the stages of technology implementation. At the control stage of the pedagogical experiment with the help of methods of mathematical statistics the results of the research were obtained, on the basis of which the efficiency of the introduced technology of information and communication competence formation was proved.
Current views on pathogenesis of oral complications with diabetes mellitus (literature review)
Authors: Tkachuk S. S. , Tkachuk O. V. , Galagdina A. A. , Povar M. A. , Perepeliuk M. D.
Published: February 2021

The aim of the study is to analyze current views on pathogenesis of lesions of the oral mucous membrane in patients with diabetes mellitus (DM).Conclusion. Analysis of the world scientific literature is indicative of the fact that deterioration of the blood circulation and oxidative stress underlie oral complications of DM.
The condition of neuro-endocrine systems in acute experimental myocardial infarction against the background of various reactivity of the organism
Authors: Popov V. M.
Published: February 2021

The adequacy of recovery processes in myocardial infarction (MI) significantly depends on the state of reactivity of the organism, which, in turn, is determined by the adequacy of neuro-endocrine regulation, in particular, hypothalamic-pituitary-adrenocortical (HPA) and hypothalamic-pituitary-thyroid (HPT) system system.Purpose of the study. To investigate the condition of HPA and HPT in acute experimental MI against the background of different reactivity of the organism.Material and methods. The study was performed on 20 outbred adult dogs weighing 8-12 kg, in which MI was simulated by ligation of the anterior interventricular artery. Animals were divided into three groups (n =5 in each group). The condition of hyperreactivity was caused by the introduction of pyrogenal (group 2), the state of hyporeactivity - the introduction of azothioprine (group 3), in group 1 drugs were not used (state of normoreactivity). In the control group used 5 falsely operated dogs with thoracopericardiotomy. In animals before surgery, on 1, 4, 7, 11 and 15 days in the blood was determined by the content of adrenocorticotropic hormone  (ACTH), thyroid-stimulating hormone (TSH) , cortisol (Cr), aldosterone (Ald), thyroxine and triiodothyronine. Statistical processing was performed using license packages Statistica 5.5 (Stat Soft Rus), Statistica Neural Networks (Statsoft Inc.).Results. Normoreactive course of myocardial infarction was characterized by primary activation of HPA, which was most pronounced for Cortisol, followed by restoration of ACTH and Aldosterone levels and duration of activation of the central link up to 4 days, peripheral - up to 7-11 days; reciprocal in relation to HPA inhibition of the functional activity of the HPT, most pronounced on the 4th day and lasting up to 15 days. Such changes caused the healing of myocardial infarction through the formation of a full-fledged post-infarction scar. The hyperreactive course of myocardial infarction was characterized by hypersecretion of ACTH with hypercorticism and hyperaldosteronism and less pronounced suppression of HPT with the restoration of its functional activity on the 7th day. The hyporeactive course of myocardial infarction was characterized by a minimally pronounced and delayed up to 4 days activation of HPA with Aldosterone hyposecretion on the 15th day; deep hypothyroidism of both central and peripheral genesis. Impaired reactivity was accompanied by an increase in the area of necrosis and a decrease in the thickness of the heart wall with the formation of postinfarction aneurysm.Conclusions. Desynchronization of necrotic and reparative processes with a change in reactivity leads to a disruption in the relationship between necrosis and repair with the formation of postinfarction aneurysm, which is accompanied by different activities of the HPA and HPT.
Analysis of changes in the education system in contemporary societies on the example of Poland and Finland
Authors: Kurowicka Ewelina Anna
Published: February 2021

Education is an important field that is the basis for functioning in a modern society. For this reason, there is a need for all activities related to the organization of the teaching process to be carried out in an effective way that will create optimal conditions for teachers to transfer their knowledge to students. It is important to create an education system that will respond to the current challenges in the field of teaching and educating a young person. One of the most important factors determining the proper course of the education process is the appropriate preparation of the teaching staff. In this publication, the basic concepts related to education and the educational system will be discussed. The aim of this article is to analyze the changes in the education system on the example of Poland and Finland.
Use of nanomodified polypropylene net in surgical treatment of umbilical hernias combined with diastasis of straight muscles
Authors: Lutkovskyi Ruslan
Published: February 2021

Aloplasty of umbilical hernias (UH) with diastasis of rectus abdominis (DRA) of using modified polypropylene mesh antiseptic and an by carbon nanotubes, buth this is accompanied by a fairly high freguency of postoperative complications from the postoperative wound.In our view, the use of a nanomodified polypropylene mesh modified by carbon nanotubes and an antiseptic of polyhexamethleneguanidme chloride the results of surgical treatment UH of DRA.Aim – to improve the results of surgical treatment of umbilical hernias with diastasis of rectus abdominis.Materials and methods. The analysis of surgical treatment of 118 patients with UH of DRA of has been performed. Depending on the type of mesh used during surgical treatment, patients were divided into 2 groups. In 59 (50%) of Group I patients, using modified polypropylene mesh antiseptic and an by carbon nanotubes. In the 2ndgroup, 59 (50%) patients using classic polypropylene mesh.Results and discussion. Statistically significant results were obtained in patients of Group I compared to Group II: seroma was in 12 (20.3±1.2%) in Group II compared to 2 (3.4±0.3%) in Group I (p<0.05), respectively, the suppuration of the postoperative wound – 2 (3.4±0.3%) to 0% (p<0.05). The terms of stay of patients of group II on inpatient treatment – 12,3±2,2 days group II – 7,5±1,5 days.Long-term results: chronic pain in the abdominal wall in 6 – 8 months after surgery was observed in 2 (3.4±0.3)% patients in group II and in 1 (1.8±0.3%) group I (p>0.05), recurrences of hernia were found in 6 (5.9±0.5%) patients of group II, in group I – in 1 (0.9±0.2)% (p<0.05).Conclusion. Surgical treatment of UH of DRA using modified polypropylene mesh antiseptic and an by carbon nanotubes the use of the classical polypropylene mesh, namely, reducing the freguency of seroma from 20.3±1.2% in the II group of patients to 3.4±0.3% in group I, respectively, suppurations of postoperative wounds – from 3.4±0.3% to 0%, inflammatory infiltrates – from 3.4±0.3% to 0%, chronic postoperative pain – from 3.9±0.4% to 0%, recurrence of hernia–from 5.9±0.5% to 0.9±0.2%.
The effectiveness of hippotherapy in relation to cerebral palsy - a review
Authors: Bator Damian , Wójcik Magdalena , Szarpak Julita , Nieścior Hubert , Dąbrowska Justyna , Piecewicz-Szczęsna Halina
Published: February 2021

Cerebral Palsy (CP) includes a group of movement and posture development disorders which cause activity limitation and are related to non-progressive disturbances during the fetal or infant brain development. In recent years, the use of hippotherapy as a rehabilitation of spstatic movement disorders in patients with  cerebral palsy is gaining in popularity. Hippotherapy is a physical therapy treatment based on the horse's movements, under the direction of an expert physical therapist. The horse's seat is considered as a dynamic support base. Thus, it is an excellent tool to improve and develop postural control, trunk strength, and balance. It allows to build overall postural strength and endurance, address weight-bearing, and motor planning. The therapeutic results obtained with the application of hippotherapy treatments has encouraged research into developing an advanced hippotherapy platform or simulators that "imitate" the movements of a horse, so that this therapy may be more accessible and adaptable to patients. The purpose of this report is to identify the forms and programmes of hippotherapy used, and to summarise and assess the latest available evidence of their clinical effectiveness in the rehabilitation of symptoms in patients with cerebral palsy. Method: a  review of publications on the effectiveness of hippotherapy programmes in the rehabilitation of symptoms in patients with cerebral palsy. Finally, 8 original tests were included in the review whose data have been extracted. The results of the research indicate that hippotherapy may be beneficial in the rehabilitation of symptoms in patients with cerebral palsy. The review suggests that further research is needed to establish a solid evidence base for hippotherapy among people with these problems. The promising results so far support further research projects.
Pelvic fractures in combination with other segmental bone injuries at the polytrauma - possibilities of platelet-rich plasma application
Authors: Ivchenko D. V. , Trufanov I. I.
Published: February 2021

Introduction. The urgency of the problem of polytrauma is due to the constant increase in the number of road accidents, armed conflicts, terrorist acts, accompanied by the appearance of a large number of victims with severe and extremely serious injuries.Purpose of study: to analyze the scientific literature and the results of our own experimental research and to summarize data on current trends and relevance of studying the main factors determining the development of disorders in victims with pelvic fractures in combination with multiple and combined injuries, to improve the prognostic criteria based on a comprehensive assessment of the clinical course of the disease and optimization of treatment by activating reparative regeneration of bone tissue with platelet-rich plasma.Materials and methods. In the period from 2017 to2018 in the department of severe concomitant injury of the City Clinical Emergency and Medical Care Hospital of Zaporozhye, 35 patients with pelvic concomitant injury were operated. There were 19 men (54.29%) and 16 women (45.71%), aged from 23 to 77 years old, median – 39 years.22 injured persons (62.86%) had road traffic injuries, 10 (28.57%) had household injuries, 2 (5.71%) had production injuries and 1 more (2.86%) had others. ISS scale less than 17 points was found in 20 patients (57.14%), from 17 to 25 – in 12 (34.29%), from 26 to 40 – in 2 (5.71%), more than 40 – in 1 (2.86%).In all patients (100%) varying degrees of pelvic bone injuries were verified. These lesions of the pelvic ring were more often combined with fractures of the proximal femur with a traumatic brain injury - 17 cases (48.57%), with concomitant fractures of extremities of other localization - 12 (34.29%), with intraperitoneal injury - 11 (31.43%), with vertebral fractures - 9 (25.71%), with chest trauma - 6 (17.14%).Results. In the main group of patients with treatment by platelet-rich plasma radiological visible adhesions of the key injured area in 8 weeks occurred in 10 people (83.33%). In 1 patient (8.3%) fusion occurred after 12 weeks and in 1 (8.3%) – 16 weeks after surgery. In the control group fusion at 8 weeks was detected in 14 patients (60.87%), in 8 patients (34.78%) – at 16 weeks.Conclusion. Reliably substantiated data were obtained according to the results of the analysis of contingency tables 4*4 and the calculation of χ2 for the efficiency coefficient according to the Wald formula (Chi-square 6.87 with p=0.009), which indicate the best clinical positiveness of the technique with the additional introduction of platelet-rich plasma into the treatment regimen as part of assessing the dynamics of fracture consolidation processes in victims with multiple and concomitant injuries, which allows us to predict a favorable outcome in these patients.
Facilitation qualities of the future teacher
Authors: Prokopenko Iryna
Published: February 2021

The realities of today require active, creative future professionals who are trained in pedagogical universities. Therefore, in order to intensify the educational activities of students, special attention should be paid to the organization of facilitation interaction in the following dyads: "teacher-group", "teacher-student", "student-group", "student-student". Currently, insufficient attention is paid to the problem of facilitation interaction between teachers and students. If in the traditional conditions the organization of the educational process is possible on the basis of facilitation interaction, then in the conditions of the pandemic (COVID-19) teachers and students had to face unexpected difficulties due to the introduction of self-isolation. The author proved that if the system of higher education still functioned quite effectively online, the school education system was not ready for self-isolation. In Ukraine, by March 2020, less than 1% of students studied remotely. It should be noted that the closure of general secondary education and the emergency transition to distance learning are associated with obvious problems, mainly due to insufficient technical equipment, lack or insufficient training of both teachers and students to work in a pandemic. The author raises the problem that the organization of facilitation interaction of teachers with students requires the formation of the teacher's facilitation qualities.
Severe eye injury as a result of the shooting of an elastic bullet of a 12-gauge cartridge "Teren-12P" - case study
Authors: Sapielkin Viktor , Pletenetska Alina
Published: February 2021

The misuse by law enforcement of regular smooth-bore rifles, loaded with bullets with elastic bullets, to end a group disruption of public order or riots, usually leads to untold injuries of a large number of people and can lead to unpredictable social and political consequences. During the period November 2013 - February2014 inKievand other cities ofUkraineduring the mass protest actions numerous cases of application by individual officials of law enforcement bodies of pump guns of the 12th caliber of the Fort-500 model series, equipped with cartridges of non-lethal action "Teren-12P" and "Teren-12K". As an example of the use of shock-traumatic firearms, we cite a case from our own practice (a gunshot wound to the eye of a participant in mass protests, February, 2014 у.Kiev).
Physical therapy of static and dynamic motor disorders in children with hemiplegic cerebral palsy
Authors: Nekhanevych Oleh , Byoung-Yul Yun
Published: February 2021

IntroductionRegardless an improgressive habit of neural disorders in cerebral palsy (CP), without a therapy the motor abnormalities’ severity rising is registered and as a result with age the physical dysfunction progressively increases.PurposeTo improve the static and dynamic motor disorders’ and activity limitations physiotherapy efficiency among the children with hemiplegic CP form via the therapeutic training program on the developed device for rehabilitation of the people with muscle-skeleton disorder.Material and methods 24 children with unilateral CP aged from 6 to 11 were enrolled into the research. The patients were randomized into 2 groups. Additionally to the standard physiotherapy complex the I group were prescribed with the walking trainings on the rehabilitation device according to the dynamic method, the II group – according to the static method. Physiotherapy program duration was 6 weeks. The gait spatiotemporal characteristics and activity limitations were monitored.Results Appling developed program influenced on the walking spatiotemporal indexes in the both groups. The biggest increase of the distance and stride length were reached exactly on the 2  week. Herewith, distance incremental amount in the I group was higher than in the II study group. TUG test’s time decreased statistically efficiently in the I group. Maximum TUG test’s index depression was observed on the 6th study weeks. As a result GMFM-66 increased in I group.Conclusions             An administration of the developed therapeutic program affected positively on the CP patients’ spatiotemporal walking characteristics, balance and endurance, as a result, decreased the fall risk and activity limitations.
Pain as a determinant of outgoing dispatch to events for Basic and Specialist Medical Rescue Teams on the example of the city of one of the selected provinces in Poland
Authors: Musiał Paweł
Published: February 2021

Pain is perceived by patients as a multi-stage component of feelings and ailments that have accompanied the individual since the dawn of time. Diagnostics of pain is a problem that is subject to constant analysis in order to eliminate the symptoms that repeatedly constitute the basis for qualifying them to take medical actions to relieve pain and ensure full psycho-physical comfort. Pain is repeatedly a component of the ongoing pathological process in the body.
Hif-1α and IGF Expression in Endometrial Hyperplasia
Authors: Chumak Z. V. , Shapoval M. V. , Andrievskiy O. G.
Published: February 2021

The objective: to assess the effect of insulin resistance and hypoxia on the risk of endometrial hyperplasia development. The research was conducted on the base of Municipal Maternity House №5 (Odessa, Ukraine). The data obtained from the sample of 417 reproductive, perimenopausal, and postmenopausal age women who referred for medical care to the gynecological department, were analyzed. All the women under examination were carried out medical and diagnostic scraping of the uterine cavity. Results. The intensity of hypoxia increases with age and closely correlates (r=0,78) with the level of insulin resistance. IGF demonstrates reverse dynamics – its rates has been diminished with age (r=-0,63). Conclusion. It was demonstrated that insulin resistance and hypoxia play significant role in the pathogenesis of endometrial hyperplasia. Indices of IGF and HIF could be recommended as valuable biomarkers of prognosis in the case of endometrial hyperplasia.
Renoprotective action of mucosa-adhesive phytogel "Biotrit" in rats, treated with oral application peroxide sunflower oil
Authors: Stepan V. T.
Published: February 2021

Aim. Determine the renoprotective activity of oral “Biotrit” gel when exposed to peroxide sunflower oil (PSO).Methods. PSO was obtained by heating the oil at +180 ° C for 60 minutes in the presence of 1.5% H2O2. Used mucosa-adhesive phytogel "Biotrit", containing bioflavonoids from wheat leaves.  Rats received oral applications of  PSO at a dose of 0.5 ml/rat for 5 days. A part of the rats received 30 minutes before the application of the PSO application of the “Biotrit” gel. The activity of elastase, catalase, urease, lysozyme and the content of MDA were determined in the kidneys. The ratio of catalase and MDA was calculated the API index, and the ratio of the relative activities of urease and lysozyme – the degree of dysbiosis.Results. In rats treated with PSO, the activity of elastase, urease, and MDA content increased but lysozyme activity and the API index decreased in the kidneys. Applications of the gel "Biotrit" reduce the activity of elastase, urease, increase the activity of lysozyme and the API index.Conclusion. Consumption of PSO causes the development of nephropathy; Oral applications of the gel "Biotrit" prevent the development of peroxide nephropathy.
Correlation of body composition with depression level
Authors: Kusari Nertila , Sukova-Stojmanovska Daniela , Elezi Abdulla
Published: February 2021

Background:  The purpose of this paper is to determine the impact of body development and composition on the depression level, and to determine which of the morphological and body composition parameters have higher impact on the manifestation of depression in women aged  19 to 30 years.Methods: The study was conducted on the sample of 50 voluntarily selected test subjects. From 83 women presented at the fitness center “Fitnes Center Mall” in the city of Gjakova for the purposes of this study are voluntarily involved 50 women aged 19 to 30 years with an average age of 23.2 years. For the purpose of this paper were applied 11 body composition variables  and one test for measuring depression levels.Results: The obtained results show that the multiple correlation coefficient between the predictor and the criterion system is quite high R = 0.962. This relation shows that the common variability between the two systems is 93% (R Square = 0.926). Predictive variables that has the influence in the manifestation of depression level are: Height of the body body (HEIG) t=2.784; p<0.008, Body weight (WEIG)  t=-2.194; p<0.034,  and Body mass index (BMI) t=2.908; p<0.006. Conclusions: The research results show that Height of the body,  Body weight,  and Body mass index affect in the rate of depression level. Research shows that although mental and physical health are two separate concepts, yet they are still in a strong relationship, physical condition affects in mental state.
Arsen Richynsky "Hygiene course of health sciences": history of the publication and main ideas
Authors: Kravchuk Olena
Published: February 2021

The article analyzes the work of the well-known socio-political, cultural and educational figure of Ukraineof the first half of the XX century, Arsen Richynsky "Hygiene course of health science", which has not lost its relevance today. The issue of organization of hygienic education and training of students in Ukrainian schools and gymnasiums of the times of the Ukrainian People's Republic of 1917-1920 is considered. Little-known milestones of the author's biography related to the writing of this book are revealed.
Comparative effect of different pathogens on the condition of dysbiosis in rat kidneys
Authors: Levitsky A. P. , Selivanskaya I. A. , Stepan V. T. , Pustovoit P. I. , Stepan B. T. , Stepan N. A.
Published: February 2021

Aim. Compare the effect of different pathogens on the development of kidney dysbiosis.Methods. The pathogens used were hydrazine sulfate, prednisolone, cyclophosphamide, lincomycin, and lipopolysaccharide (LPS). The condition of kidney dysbiosis was assessed in rats by a decrease in lysozyme activity and an increase in urease activity.Results. A decrease in the activity of lysozyme in the kidneys under the action of pathogens was established, which, when calculated per 1 mg of a pathogen, is hundreds of times stronger in LPS. All pathogens cause an increase in urease activity in the kidneys, which, when calculated per 1 mg of a pathogen, is hundreds of times stronger in LPS. A similar effect is exerted on the degree of dysbiosis, determined by the ratio of the relative activities of urease and lysozyme.Conclusion. All pathogens (except lincomycin) cause the development of dysbiosis in the kidneys, due to the possible bacteriolysis of tissue gram-negative bacteria with the release of LPS.
Forecast and clinical-diagnostic significance of increased expression of beta-2microglobulin in the urine in the process of nephropathy formation in essential hypertension
Authors: Kulynych R. L. , Rekalov D. G.
Published: February 2021

Introduction. At present, it is obvious that the prognosis for the life of patients with essential hypertension, according to the cardiovascular continuum, is clearly determined primarily by the involvement in the pathological process of target organs and the severity of their structural and functional changes.The aim of the study is to identify the clinical-diagnostic and prognostic value of B2-MGU as a marker of kidney damage in essential hypertension.Materials and methods. To achieve this goal, 46 patients with essential hypertension (45.65% women and 54.35% men) aged from 28 to 71 years (mean age was 51.88 ± 2.17 years), I-II stage of the disease with level of hypertension I-III degree, varying degrees of risk, who did not receive systematic adequate antihypertensive therapy and in which as a result of comprehensive clinical, laboratory and instrumental studies there were no evidence of clinically significant chronic kidney disease. The control group consisted of 17 healthy individuals.Results. In patients with essential hypertension is forming hypertensive nephropathy, which is characterized by statistically significant excessive excretion of beta-2-microglobulin in the urine compared with almost healthy individuals. In patients with increased excretion of beta-2-microglobulin violations of intrarenal hemodynamics were registered significantly more often, violations of functional renal reserve, violations of vascular resistance of renal vessels, in a significantly higher percentage there were pathological changes in circadian rhythm of blood pressure and renal filtration function, the prevalence of concentric and eccentric hypertrophy, proteinuria, which indicates an important clinical, diagnostic and prognostic value of hyper-beta-2-microglobulinuria.Conclusions. The indicator beta-2-microglobulinuria can be used as an adequate marker of hypertensive nephropathy, as having high sensitivity, specificity, positive and negative prognosis.
Patogenetic relationship between the corneal epithelial thickness and microcirculation in the conjunctiva during optical coherent tomography in healthy subjects without ophthalmopathology
Authors: Lutsenko N. S. , Unguryan N. V.
Published: February 2021

Relevance. The ocular surface is composed of various tissue components, and all of these components work together to maintain the integrity and normal function of the ocular surface.Aim of the work: to study of indicators of the blood flow of the bulbar conjunctiva and the state of the corneal epithelium in a group of conventionally healthy individuals and assessment of their physiological relationship.Materials and methods. The study involved 20 apparently healthy people (40 eyes) of the Caucasian race, aged from 25 to 53, without concomitant ophthalmopathology. During the examinations, the state of the cornea (thickness of the cornea, epithelium) and bulbar conjunctiva were determined. The study of patients was carried out for 5 months from May to October 2020 on the basis of the Department of Eye Diseases of the State Institution "Zaporozhye Medical Academy of Postgraduate Education of the Ministry of Health ofUkraine" in the Department of Eye Microsurgery inZaporizhzhiaRegionalClinicalHospital.Results. With the help of angio-optical coherence tomography, the density of vessels of the superficial and deep plexuses of the conjunctiva were studied and the normative base of conventionally healthy patients was formed. The density of the vessels of the superficial plexus at a distance of 1, 2 and 3 mm from the limbus did not differ significantly and averaged 50.7 µm. The density of the vessels of the deep plexus on average was 55.7 µm, but did not differ significantly from the indices of the superficial plexus. In the study of the density of the vascular bed of the deep plexus, statistically significant (p<0.05) more intense blood flow was noted at a distance of 2 mm from the limbus, and the lowest density of vessels at the level of 1 mm from the limbus. A statistically significant associative logical relationship between the dynamics of the thickness of the cornea and its epithelium was established, and the ratio of the thickness of the cornea to its epithelium was calculated in practically healthy individuals, which is within 9-11 conv. units.Conclusions. The proposed normative reference values of a group of healthy individuals will allow both to adequately assess the functional ability of the corneal epithelium, to assess the density of blood flow of the bulbar conjunctiva and episclera, and to timely rationally select personally pathogenetically justified treatment and rehabilitation measures, taking into account the severity of pathological changes in the cornea at the subclinical stage.
Telemedicine in neurosurgery during SARS-CoV2 Pandemic
Authors: Golebiowska Maria , Golebiowska Beata
Published: February 2021

Introduction and purposeFirst large scale introduction and research of telecommunication in medicine was conducted in year 1977. However, until current SARS-CoV-2 Pandemic, telemedicine has been used only in emergency interventions or in cases in which only remote healthcare provision services were available. Healthcare was forced to implement telemedical changes in a scale broader beyond imagination, in order to limit the risk of COVID transmission and preserve the scarce healthcare resources. Especially in surgical fields, such as neurosurgery, which strongly depend on on-site procedures, this time has been extremely demanding. The aim of the study is to present the current views and effectiveness of implementation of telemedicine in neurosurgery during SARS-CoV2 pandemic. Substantial articles on implementation and challenges of telemedicine in neurosurgery from period 02.2020-09.2020 were analyzed.  Current state of knowledgeWithin 581 articles of PubMED database, 15 substantial articles on advancements of telemedicine in neurosurgery during SARS-CoV2 Pandemic were included in the review. 60% of the articles discussed telemedicine implementation and improvements made, 40% of the articles discussed the legislative changes, telemedicine recommendations and good pratices. Most of the articles noted the significant increase in provision of services using telemedicine and high satisfaction of patients and professionals from the remote visits. However, many challenges of the technology has been encountered including difficulties in conducting proper remote examination, lack of standarized protocols, concerns of the ethical and social matters, such as patient’s confidentiality and privacy concerns, digital illiteracy in patients, and the need for more advanced hardware and more secure software for the provision of high quality services. Conclusions Reviewed research presents significant improvements in introduction of telemedicine in neurosurgical field in times of COVID Pandemic, however due to many multidisciplinary concerns regarding telemedicine implementation, face-to-face examination and communication still should take priority over the telemedicine interventions in the non-emergency future.
Impact of coronavirus disease (Covid-19) within the third trimester of pregnancy
Authors: Boychuk A. V. , Khlibovska O. I. , Yakymchuk Y. B.
Published: February 2021

Introduction. Assessment of pregnancy, fetal status, diagnosis of placental insufficiency (PI) in pregnant women with coronavirus COVID-19, is a topical issue in obstetric practice and is of great social value for the birth of healthy children.The aim of our study was to analyze the impact of coronavirus disease on pregnancy and fetal status.Methods and materials.  An examination of 25 pregnant women who relapsed into Covid-2019, who were treated at Public Non-profit Enterprise Ternopil Municipal City Hospital No. 2. The control group consisted of 25 pregnant women with a physiological course of pregnancy, who gave birth to live full-term infants with mass-growth characteristics according to gestational age. The condition of the fetus was assessed according to ultrasound, cardiotocography. Criteria for inclusion in the study were laboratory confirmed by COVID-19 by polymerase chain reaction (PCR).Results and discussion. It was found that coronavirus disease was present in pregnant women 21 (84.0%) in mild form, 4 (16.0%) patients had pneumonia, but did not require hospitalization and did not require artificial ventilation, and were treated at home by a family doctor. The main complaints of patients were fever in 84.0% (21 pregnant women), cough - in 78.0% (19 pregnant women), myalgia - in 62.0% (15 pregnant women), headache - 84.0% (21 pregnant women) , sore throat - in 40.0% (10 pregnant women), general weakness in 70.0% (17 pregnant women). And 6 pregnant women (20%) of those surveyed had a mild asymptomatic course of the disease. The condition of the fetus was assessed by ultrasound and CTG of the fetus. Decrease in amplitude of oscillations less than 3 beats / min, absence of accelerations, emergence of decelerations, testify to the expressed signs of a hypoxia of a fruit and demand timely treatment and the decision of a question of urgent delivery.
Comparative nephroprotective efficiency of polyfunctional mucous-adhesive phytogels
Authors: Gozhenko A. I. , Levitsky A. P. , Stepan V. T. , Selivanskaya I. A. , Pustovoit I. P.
Published: February 2021

Aim. To compare the nephroprotective effect of oral applications of different phytogels in experimental kidney pathology.Methods. We used phytogels: "Kvertulin" (quercetin + inulin + calcium citrate), "Biotrit" (juice from wheat germ) and "Dubovy" (extract from oak wood).Experimental models were reproduced in rats: diabetic syndrome, prednisolone immunodeficiency, intoxication with thermal peroxide sunflower oil. The condition of the kidneys was assessed by changes in the level of biochemical markers in the kidney tissue (elastase, urease, lysozyme, MDA, the degree of dysbiosis).Results. Experimental pathologies cause an increase in the level of elastase, urease, MDA, the degree of dysbiosis, and a decrease in lysozyme activity in the kidneys. Oral application of phytogels caused a decrease in the activity of elastase, urease, MDA content and the degree of dysbiosis, but increased the activity of lysozyme. When recalculating the degree of decrease in elastase activity and increase in lysozyme activity per 1 g of phytogel or 1 mg of active principle (quercetin or the amounts of polyphenols), phytogel "Kvertulin" turned out to be the most effective anti-elastase agent, and phytogel "Biotrit" turned out to be the most effective lysozyme-reducing agent.Conclusion. Oral applications of multifunctional mucous-adhesive gels have a nephroprotective effect in experimental kidney pathology.
Biofeedback as a form of neurorehabilitation in Parkinson's disease
Authors: Iłżecka Joanna
Published: February 2021

Parkinson's disease is a degenerative disease of the nervous system. An important element in the treatment of the disease is neurorehabilitation. One of the forms of neurorehabilitation may be biofeedback. The above technique uses electronic devices that allows an individual to learn how to change the body's function in order to reduce the clinical symptoms of the disease and improve health. Previous studies have confirmed that biofeedback has a beneficial effect on the health of patients with Parkinson's disease. The aim of the work was a review of the literature on biofeedback as a form of neurorehabilitation in this disease.
Uncertainty, Imagination, Hope and Utopia
Authors: Gotsis Ilias , Kiapoka Anna S.
Published: February 2021

During the early stages of the Covid-19 crisis, a center in Greece organized a volunteer team for mental care and empowerment. About 300 mental health professionals participated, running systemic Appreciative Inquiry empowerment tele-groups using appreciative tools and creative writing. They shared their dreams for the future in Dreamland, a Facebook group created specifically for them.