bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic Review of Tularemia During Pregnancy
Authors: Fleck-Derderian Shannon , Davis K Meryl , Winberg Jessica , Nelson Christina A , Meaney-Delman Dana
Published: January 2024

Background

Tularemia is caused by the gram-negative bacterium Francisella tularensis. Although rare, tularemia during pregnancy has been associated with pregnancy complications; data on efficacy of recommended antimicrobials for treatment are limited. We performed a systematic literature review to characterize clinical manifestations of tularemia during pregnancy and examine maternal, fetal, and neonatal outcomes with and without antimicrobial treatment.

Methods

We searched 9 databases, including Medline, Embase, Global Health, and PubMed Central, using terms related to tularemia and pregnancy. Articles reporting cases of tularemia with ≥1 maternal or fetal outcome were included.

Results

Of 5891 articles identified, 30 articles describing 52 cases of tularemia in pregnant patients met inclusion criteria. Cases were reported from 9 countries, and oropharyngeal and ulceroglandular tularemia were the most common presenting forms. A plurality (46%) of infections occurred in the second trimester. Six complications were observed: lymph node aspiration, lymph node excision, maternal bleeding, spontaneous abortion, intrauterine fetal demise, and preterm birth. No deaths among mothers were reported. Of 28 patients who received antimicrobial treatment, 1 pregnancy loss and 1 fetal death were reported. Among 24 untreated patients, 1 pregnancy loss and 3 fetal deaths were reported, including one where F. tularensis was detected in placental and fetal tissues.

Conclusions

Pregnancy loss and other complications have been reported among cases of tularemia during pregnancy. However, risk of adverse outcomes may be lower when antimicrobials known to be effective are used. Without treatment, transplacental transmission appears possible. These data underscore the importance of prompt recognition and treatment of tularemia during pregnancy.
Utilization of and perceived need for simulators in clinical electrophysiology: results from an EHRA physician survey
Authors: Tjong Fleur V Y , Perrotta Laura , Goette Andreas , Duncker David , Vernooy Kevin , Boveda Serge , Chun Kyoung-Ryul Julian , Svennberg Emma
Published: January 2024

Aims

Simulator training has been recently introduced in electrophysiology (EP) programmes in order to improve catheter manipulation skills without complication risks. The aim of this study is to survey the current use of EP simulators and the perceived need for these tools in clinical training and practice.

Methods and results

A 20-item online questionnaire developed by the Scientific Initiatives Committee of the European Heart Rhythm Association (EHRA) in collaboration with EHRA Digital Committee was disseminated through the EHRA Scientific Research Network members, national EP groups, and social media platforms. Seventy-four respondents from 22 countries (73% males; 50% under 40 years old) completed the survey. Despite being perceived as useful among EP professionals (81%), EP simulators are rarely a part of the institutional cardiology training programme (20%) and only 18% of the respondents have an EP simulator at their institution. When available, simulators are mainly used in EP to train transseptal puncture, ablation, and mapping, followed by device implantation (cardiac resynchronization therapy [CRT], leadless, and conduction system pacing [CSP]). Almost all respondents (96%) believe that simulator programmes should be a part of the routine institutional EP training, hopefully developed by EHRA, in order to improve the efficacy and safety of EP procedures and in particular CSP 58%, CRT 42%, leadless pacing 38%, or complex arrhythmia ablations (VT 58%, PVI 45%, and PVC 42%).

Conclusion

This current EHRA survey identified a perceived need but a lack of institutional simulator programme access for electrophysiologists who could benefit from it in order to speed up the learning curve process and reduce complications of complex EP procedures.
7. Islam and International Relations in the Middle East: From Umma to Nation State
Authors: Mandaville Peter
Published: January 2024

This chapter takes up the story of identity from an Islamic perspective. In a historically informed account, it shows how Islam has interacted with the domestic, regional, and international politics of the region and how its influence has ebbed and flowed alongside different currents in regional and international relations. The chapter also considers globalization as a facilitator of transnational Islam, but by no means a force for union. The chapter discusses the substantive presence of religion in the foreign policies of the Middle Eastern states, including those which are more overtly Islamic, such as Saudi Arabia and Iran. It investigates the popular uprisings in the Arab world which created new opportunities and challenges for the Islamic movement, and which continue to affect states’ foreign policies notably through the phenomenon of sectarianization.
9. Security in the Middle East: Whose Security?
Authors: Bilgin Pinar
Published: January 2024

This chapter takes a critical look at the question of security in the Middle East by asking whose security concerns have been principally addressed in the history of the modern region. It traces the origins of the invention of the Middle East in Britain’s colonial practices. It also reviews how the politics of the Cold War impinged on local dynamics, including the ways in which women were rendered insecure by virtue of dominant statist and top-down approaches to security. The chapter considers the wider implications of non-state actor activism for the future of regional security. It discusses the collaboration between like-minded policymakers and other elites in North America, Western Europe, and the Middle East that tilted the balance against civil society in the Arab World and made the life of the average Arab citizen a terrible field of insecurity.
Association of metformin use and cancer incidence: a systematic review and meta-analysis
Authors: O’Connor Lauren , Bailey-Whyte Maeve , Bhattacharya Manami , Butera Gisela , Hardell Kaitlyn N Lewis , Seidenberg Andrew B , Castle Philip E , Loomans-Kropp Holli A
Published: January 2024

Background

Metformin is among the most widely used antidiabetics medications because of its minimal toxicity, favorable safety profile, availability, and low cost. In addition to its role in diabetes management, metformin may reduce cancer risk.

Methods

We conducted a comprehensive systematic review and meta-analysis to investigate the association between metformin use and cancer risk, with evaluation by specific cancer type when possible. Applicable studies were identified in PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, and Scopus from inception through March 7, 2023, with metformin use categorized as “ever” or “yes” and a cancer diagnosis as the outcome. Article quality was evaluated using National Heart, Lung, and Blood Institute guidelines, and publication bias was evaluated using the Egger test, Begg test, and funnel plots. Pooled relative risk (RR) estimates were calculated using random-effects models, and sensitivity analysis was completed through leave-one-out cross-validation.

Results

We included 166 studies with cancer incidence information in the meta-analysis. Reduced risk for overall cancer was observed in case-control studies (RR = 0.55, 95% confidence interval [CI] = 0.30 to 0.80) and prospective cohort studies (RR = 0.65, 95% CI = 0.37 to 0.93). Metformin use was associated with reduced gastrointestinal (RR = 0.79, 95% CI = 0.73 to 0.85), urologic (RR = 0.88, 95% CI = 0.78 to 0.99), and hematologic (RR = 0.87, 95% CI = 0.75 to 0.99) cancer risk. Statistically significant publication bias was observed within the studies (Egger P < .001).

Conclusions

Metformin may be associated with a decreased risk of many cancer types, but high heterogeneity and risk of publication bias limit confidence in these results. Additional studies in populations without diabetes are needed to better understand the utility of metformin in cancer prevention.
A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's
Authors: Tornling Göran , Edenius Charlotte , Pauling John D , Denton Christopher P , Olsson Anna , Kowalski Jan , Murray Andrea , Anderson Marina , Bhat Smita , Del Galdo Francesco , Hall Frances , Korkosz Mariusz , Krasowska Dorota , Olas Jacek , Smith Vanessa , van Laar Jacob M , Vonk Madelon C , Wojteczek Anna , Herrick Ariane L
Published: January 2024

Objective

Our objective was to test the hypothesis, in a double-blind, placebo-controlled study that vipoglanstat, an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), which decreases prostaglandin E2 (PGE2) and increases prostacyclin biosynthesis, improves RP.

Methods

Patients with SSc and ≥7 RP attacks during the last screening week prior to a baseline visit were randomized to 4 weeks treatment with vipoglanstat 120 mg or placebo. A daily electronic diary captured RP attacks (duration and pain) and Raynaud’s Condition Score, with change in RP attacks/week as the primary end point. Cold challenge assessments were performed at baseline and end of treatment. Exploratory end points included patients’ and physicians’ global impression of change, Assessment of Scleroderma-associated Raynaud’s Phenomenon questionnaire, mPGES-1 activity, and urinary excretion of arachidonic acid metabolites.

Results

Sixty-nine subjects received vipoglanstat (n = 33) or placebo (n = 36). The mean weekly number of RP attacks [baseline; vipoglanstat 14.4 (S.D. 6.7), placebo 18.2 (12.6)] decreased by 3.4 (95% CI –5.8; –1.0) and 4.2 (–6.5; –2.0) attacks per week (P = 0.628), respectively. All patient-reported outcomes improved, with no difference between the groups. The mean change in recovery of peripheral blood flow after the cold challenge did not differ between the study groups. Vipoglanstat fully inhibited mPGES-1, resulting in 57% reduction of PGE2 and 50% increase of prostacyclin metabolites in the urine. Vipoglanstat was safe and well tolerated.

Conclusion

Although vipoglanstat was safe, and well tolerated in a dose achieving full inhibition of mPGES-1, it was ineffective in SSc-related RP. Further development and evaluation of vipoglanstat will therefore be in other diseases where mPGES-1 plays a pathogenetic role.

Trial registration

ClinicalTrials.gov, https://www.clinicaltrials.gov, NCT0474420.
2023 ACR/EULAR classification criteria in existing research cohorts: an international study
Authors: Foddai Silvia G , Radin Massimo , Cecchi Irene , Rubini Elena , Barinotti Alice , Alba Paula , Gimen Alonso Carla , Rossi Daniela , Roccatello Dario , Sciascia Savino
Published: January 2024

Objective

To assess the impact of the updated ACR/EULAR APS classification criteria on two large research cohorts.

Methods

Consecutive patients who tested persistently positive for at least one aPL in the last three years were enrolled. The first APS Sydney index event was considered and computed for the comparison between Sydney and 2023 APS criteria. When computing the 2023 APS criteria, additional manifestations were also considered.

Results

The cohort comprised 249 patients (185 with APS and 64 aPL carriers according to Sydney criteria). The 185 patients had as first index event venous thrombosis in 55 cases (29.8%), arterial thrombosis in 63 (34%) and pregnancy morbidity in 67 (36.2%). When applying the updated criteria, 90 subjects (48.7%) failed to reach the composite score of the new criteria. The percentage of thrombotic APS per Sydney criteria decreased from 47.3% to 34.9% because of high cardiovascular risk in 23 cases, IgM aPL profile in six cases and in two patients for both reasons. Patients with pregnancy morbidity decreased from 26.9% to 3.2% (39 cases of recurrent early pregnancy loss and 20 of fetal losses). Consequently, the percentage of aPL carriers increased from 26% to 61%. When looking at the disease evolution at follow-up, 32 additional patients out of 90 (35.6%) fulfilled the new APS criteria, after developing additional clinical manifestation following index event.

Conclusion

When applying the new APS criteria to our research cohorts, not-negligible differences exist in patients’ classification. A multidisciplinary approach will be mandatory to assess the impact of the new criteria on research and, ultimately, patients’ care.
Use of methane production data for genetic prediction in beef cattle: A review
Authors: Dressler Elizabeth A , Bormann Jennifer M , Weaber Robert L , Rolf Megan M
Published: January 2024

Methane (CH4) is a greenhouse gas that is produced and emitted from ruminant animals through enteric fermentation. Methane production from cattle has an environmental impact and is an energetic inefficiency. In the beef industry, CH4 production from enteric fermentation impacts all three pillars of sustainability: environmental, social, and economic. A variety of factors influence the quantity of CH4 produced during enteric fermentation, including characteristics of the rumen and feed composition. There are several methodologies available to either quantify or estimate CH4 production from cattle, all with distinct advantages and disadvantages. Methodologies include respiration calorimetry, the sulfur-hexafluoride tracer technique, infrared spectroscopy, prediction models, and the GreenFeed system. Published studies assess the accuracy of the various methodologies and compare estimates from different methods. There are advantages and disadvantages of each technology as they relate to the use of these phenotypes in genetic evaluation systems. Heritability and variance components of CH4 production have been estimated using the different CH4 quantification methods. Agreement in both the amounts of CH4 emitted and heritability estimates of CH4 emissions between various measurement methodologies varies in the literature. Using greenhouse gas traits in selection indices along with relevant output traits could provide producers with a tool to make selection decisions on environmental sustainability while also considering productivity. The objective of this review was to discuss factors that influence CH4 production, methods to quantify CH4 production for genetic evaluation, and genetic parameters of CH4 production in beef cattle.
Enhanced Screening for Ectasia Risk: Multimodal Refractive Imaging Observations From the Fellow Unoperated Eye of Patients With Post-Laser In Situ Keratomileusis Ectasia
Authors: Salomão Marcella Q. , Hoffling-Lima Ana Luisa , Sena Nelson , Lopes Bernardo T. , Guedes Jaime , Ambrósio Renato
Published: January 2024

Purpose:

The aim of this study was to report multimodal refractive imaging findings that may predict ectasia susceptibility on nonoperated eyes of patients who developed post-LASIK ectasia in the fellow eye.

Study Design:

This is a retrospective case series.

Methods:

The nonoperated fellow eyes of 5 patients who had unilateral LASIK with progressive ectasia underwent a comprehensive ophthalmologic evaluation and multimodal refractive imaging (MRI), including Pentacam HR and Corvis ST (Oculus; Wetzlar, Germany), along with segmental OCT (RTVue; Optovue, Inc, Fremont, CA). Different objective indices and parameters from the Pentacam, Corvis ST, and OCT were analyzed.

Results:

None of the 5 cases showed ectasia detection on the Pentacam TKC (topographic keratoconus classification), and inferior–superior (IS) asymmetry values were lower than 1.0 D in all 5 cases. Corneal thicknesses at the thinnest points measured with the Pentacam were 530, 466, 517, 488, and 511 µ, and with the OCT were 512, 460, 508, 480, and 495 µ, in cases 1to 5, respectively. The keratoconus risk scoring system based on OCT measurements demonstrated a high risk in 2 patients. The BAD-D (Belin-Ambrósio Enhanced Ectasia Deviation) was higher than 1.22 in all 5 cases and higher than 1.6 in 2 cases. Four cases had ARTmax (Ambrósio Relational Thickness to the meridian with maximal progression increase) lower than 390. The PRFI (Pentacam Random Forest Index) was equal or higher than 0.12 in all 5 cases, and enhanced posterior elevation, which is calculated using data from the standard elevation map, excluding a 3.5-mm area centered on the thinnest point, was abnormal in all 5 cases. The value of the current version of the tomographic biomechanical index (TBI V1), derived from artificial intelligence (AI) algorithms, which integrate Scheimpflug-based tomography and biomechanical data, was equal or higher than 0.29 in 3 cases.

Conclusions:

Signs of ectasia susceptibility were detected in all nonoperated eyes based on multimodal imaging. These findings support the clinical relevance of such analysis when screening for ectasia risk among candidates for refractive surgery.
Recent developments of telemedicine in glaucoma
Authors: Jo Jason J. , Pasquale Louis R.
Published: January 2024

Purpose of review

Telemedicine has an increasingly significant role in the fields of ophthalmology and glaucoma. This review covers recent advancements in the development and optimization of teleglaucoma techniques and applications.

Recent findings

Glaucoma monitoring and diagnosis via remote tonometry, perimetry, and fundus imaging have become a possibility based on recent developments. Many applications work in combination with smart devices, virtual reality, and artificial intelligence and have been tested in patient populations against conventional “reference-standard” measurement tools, demonstrating promising results. Of note, there is still much progress to be made in teleglaucoma and telemedicine at large, such as accessibility to internet, broadband, and smart devices, application affordability, and reimbursement for remote services. However, continued development and optimization of these applications suggest that the implementation of remote monitoring will be a mainstay for glaucoma patient care.

Especially since the beginning of the COVID-19 pandemic, remote patient care has taken on an important role in medicine and ophthalmology. Remote versions of tonometry, perimetry, and fundus imaging may allow for a more patient-centered and accessible future for glaucoma care.
Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children
Authors: Ma Hsuan-Yin , Lin I-Fan , Liu Yun-Chung , Yen Ting-Yu , Huang Kuan-Ying A. , Shih Wei-Liang , Lu Chun-Yi , Chang Luan-Yin , Huang Li-Min
Published: January 2024

Background:

Respiratory syncytial virus (RSV) is a common cause of bronchiolitis and pneumonia in infants and young children. Starting in December 2010, RSV monoclonal antibody (RSV mAb) was endorsed by Taiwan National Health Insurance and given to children with prematurity and/or congenital heart diseases, which are considered high-risk factors for severe RSV diseases. Investigating other important contributing risk factors is warranted.

Methods:

We conducted a cohort study at National Taiwan University Hospital to determine the rate of severe outcomes among children hospitalized due to RSV infection from 2008 to 2018. Adjusted for age, sex and birth cohorts born before and after RSV mAb endorsement, we identified risk factors for severe RSV infection, defined as the requirement of invasive ventilator support.

Results:

There were 1985 admissions due to RSV infections. Among them, 66 patients (3.3%) had severe RSV infection. The proportion of severe RSV infections decreased significantly after RSV mAb endorsement. Multivariable analysis revealed that age <1.5 months and cardiovascular and congenital/genetic diseases were high-risk underlying conditions. In addition, bacterial coinfections, elevated creatinine levels and initial abnormal chest radiograph findings posed warning signs for severe RSV infection.

Conclusions:

Children younger than 1.5 months of age with cardiovascular or congenital/genetic diseases were predisposed to severe RSV infection and might benefit from RSV mAb prophylaxis.
Sir Colin Brian Blakemore. 1 June 1944—27 June 2022
Authors: Molnár Zoltán , Parker Andrew
Published: January 2024

Colin Blakemore was a giant of neuroscience, whose direct research contributions shaped our modern knowledge of vision and the senses, as well as neural development, plasticity and degeneration. His early work revealed that manipulation of the sensory environment exerts a profound influence on the growing nervous system, establishing that the activation of nerve cells is directly linked to the successful maintenance of these cells’ connections with the rest of the brain. These and many later findings set the scene for understanding that the computational functions of the brain are the outcome of adaptive processes, which continue through adult life in many cases. Publicly, Colin's distinctive voice was well known in broadcast media, notably being the youngest ever presenter of the BBC Reith Lectures at the age of 32. Colin became a regular communicator of the rapidly growing field of neuroscience and an effective advocate for the scientific understanding of our brains, bodies and mental life. He unflinchingly undertook the role of justifying the need for animal research to play its part in the development of science and medical treatment, even though sometimes this brought vilification, and even threats. Colin held many public-facing roles for scientific bodies, of which the most significant was his time as chief executive of the Medical Research Council. More personally, Colin's role as a mentor will always be remembered by his students, who benefited from Colin's remarkable ability to pause all his other activities and focus upon their scientific work and future careers.
Musculoskeletal morphogenesis supports the convergent evolution of bat laryngeal echolocation
Authors: Usui Kaoru , Yamamoto Tomoki , Khannoon Eraqi R. , Tokita Masayoshi
Published: January 2024

The order Chiroptera (bats) is the second largest group of mammals. One of the essential adaptations that have allowed bats to dominate the night skies is laryngeal echolocation, where bats emit ultrasonic pulses and listen to the returned echo to produce high-resolution ‘images’ of their surroundings. There are two possible scenarios for the evolutionary origin of laryngeal echolocation in bats: (1) a single origin in a common ancestor followed by the secondary loss in Pteropodidae, or (2) two convergent origins in Rhinolophoidea and Yangochiroptera. Although data from palaeontological, anatomical, developmental and genomic studies of auditory apparatuses exist, they remain inconclusive concerning the evolutionary origin of bat laryngeal echolocation. Here we compared musculoskeletal morphogenesis of the larynx in several chiropteran lineages and found distinct laryngeal modifications in two echolocating lineages, rhinolophoids and yangochiropterans. Our findings support the second scenario that rhinolophoids and yangochiropterans convergently evolved advanced laryngeal echolocation through anatomical modifications of the larynx for ultrasonic sound generation and refinement of the auditory apparatuses for more detailed sound perception.
Nephrogenic diabetes insipidus in a geriatric patient affected by SARS-CoV-2: complexity of a diagnosis, complexity of a virus
Authors: Corich Maria Ada , Niero Michele , Corich Lucia , Ferretti Elisabetta , De Colle Paolo , Bernardi Stella , Ceschia Giuliano , Sanson Gianfranco , Zanetti Michela
Published: January 2024

Background. Coronavirus disease 2019 (COVID-19) has an important impact on the kidney through direct and indirect damage mechanisms. Most previous studies have highlighted lesions caused by this virus in the early segments of the nephron. However, due to the antigenic characteristics of the virus, with almost ubiquitous receptors, and the molecular release it triggers, the distal segments of the nephron could also be affected.

Methods. A 71 year-old-man with respiratory failure while suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia presented with typical symptoms of diabetes insipidus after ~20 days of hospitalization. The water deprivation test led to the diagnosis of nephrogenic diabetes insipidus. The aetiological study was complex, in particular because of the patient’s previous lithium therapy.

Results. The sequence of pathognomonic events typical of diabetes insipidus associated with anamnestic, clinical and laboratory evidence strongly supported the diagnosis of nephrogenic diabetes insipidus due to SARS-CoV-2 rather than other aetiologies.

Conclusions. The collecting duct could represent a target for SARS-CoV-2 infection, directly or indirectly, as a result of lesions of upstream portions of the nephron, which would cascade into the distal segment. Other molecules, besides angiotensin 2 converting enzyme, might be involved in facilitating the viral aggression. The complexity of the geriatric patient shows the importance of a comprehensive approach that integrates careful monitoring of clinical signs and symptoms and laboratory and instrumental tests. This is especially important in the context of SARS-CoV-2 infection and in the management of its unexpected complications.
Case series on Trichomonas vaginalis infections: impact of proper sample collection and diagnostic stewardship
Authors: Agarwal Ashwini , Padhi Abhishek , Chaudhary Anil , Bhise Mayuri , Chauhan Kinjal , Sharma Medhavi , Krishan Ramotra Rohini , Dubey Pankhuri
Published: January 2024

This paper elucidates the transformative impact of a strategic shift in diagnostic practices in the detection of Trichomonas vaginalis. It explores five cases where the implementation of a specific diagnostic protocol led to effective identification of the infection. In-depth discussions and a comprehensive literature review underline the necessity for precise diagnosis and the paramount importance of diagnostic stewardship in managing sexually transmitted infections.
Safety assessment of five candidate probiotic lactobacilli using comparative genome analysis
Authors: Altavas Patrick Josemaria d.R , Amoranto Mia Beatriz C. , Kim Sang Hoon , Kang Dae-Kyung , Balolong Marilen P. , Dalmacio Leslie Michelle M.
Published: January 2024

Micro-organisms belonging to the

Lactobacillus

genus complex are often used for oral consumption and are generally considered safe but can exhibit pathogenicity in rare and specific cases. Therefore, screening and understanding genetic factors that may contribute to pathogenicity can yield valuable insights regarding probiotic safety.

Limosilactobacillus mucosae

LM1,

Lactiplantibacillus plantarum

SK151,

Lactiplantibacillus plantarum

BS25,

Limosilactobacillus fermentum

SK152 and

Lactobacillus johnsonii

PF01 are current probiotics of interest; however, their safety profiles have not been explored. The genome sequences of LM1, SK151, SK152 and PF01 were downloaded from the NCBI GenBank, while that of

L. plantarum

BS25 was newly sequenced. These genomes were then annotated using the Rapid Annotation using Subsystem Technology tool kit pipeline. Subsequently, a command line blast was performed against the Virulence Factor Database (VFDB) and the Comprehensive Antibiotic Resistance Database (CARD) to identify potential virulence factors and antibiotic resistance (AR) genes. Furthermore, ResFinder was used to detect acquired AR genes. The query against the VFDB identified genes that have a role in bacterial survivability, platelet aggregation, surface adhesion, biofilm formation and immunoregulation; and no acquired AR genes were detected using CARD and ResFinder. The study shows that the query strains exhibit genes identical to those present in pathogenic bacteria with the genes matched primarily having roles related to survival and surface adherence. Our results contribute to the overall strategies that can be employed in pre-clinical safety assessments of potential probiotics. Gene mining using whole-genome data, coupled with experimental validation, can be implemented in future probiotic safety assessment strategies.
Time to recovery of asphyxiated neonates and it’s predictors among newborns admitted to neonatal intensive care unit at Debre Berhan Comprehensive Specialized Hospital, Ethiopia
Authors: Yehouala Sisay Girma , Tesfahun Esubalew , Dejene Tadesse Mamo , Gebreegziabher Zenebe Abebe
Published: January 2024

Background

Even though there have been inquiries into the survival rates of asphyxiated neonates in Africa, there is scarce data concerning the recovery duration for asphyxiated newborns in developing nations and the factors affecting this process. Consequently, the objective of this study is to ascertain the time it takes for asphyxiated neonates to recover and identify its predictors.

Methods

Conducting a retrospective follow-up investigation, the study took place at Debre Berhan Comprehensive Specialized Hospital from January 1st, 2020 to December 31st2022, involving a sample size of 330. The analysis included the computation of the Kaplan-Meier survival curve, the log-rank test, and the median time. Additionally, a multivariable Cox proportional hazard regression model was employed to determine the survival status.

Results

in this study, among the 330 participants (100%), a total of 270(81.8%) successfully survived throughout the entire cohort. Predictors are independent of each other, affecting the time to recovery and survival of asphyxiated neonates, encompassed prolonged labor (AHR: 0.42, 95%CI:0.21-0.81), normal birth weight (AHR:2.21, 95% CI: 1.30-3.70),non-altered consciousness (AHR:2.52, CI:1.50-4.24), non-depressed moro reflex of the newborn (AHR:2.40, 95%CI: 1.03-5.61), stage I HIE (AHR: 5.11, 95% CI: 1.98-13.19), and direct oxygen administration via the nose (AHR: 4.18, 95% CI: 2.21-7.89).

Conclusion

The duration for recovery seems to be slightly prolonged in comparison to other research findings. This underscores the significance of vigilant monitoring, early preventive interventions, and swift actions to avert the progression of infants to the most severe stage of HIE.
Intermediate morphology in the patterning of the crystalline Ge(001) surface induced by ion irradiation
Authors: Erb Denise J. , Pearson Daniel A. , Škereň Tomáš , Engler Martin , Bradley R. Mark , Facsko Stefan
Published: January 2024

We investigate the morphologies of the Ge(001) surface that are produced by bombardment with a normally incident, broad argon ion beam at sample temperatures above the recrystallization temperature. Two previously observed kinds of topographies are seen, i.e., patterns consisting of upright and inverted rectangular pyramids, as well as patterns composed of shallow, isotropic basins. In addition, we observe the formation of an unexpected third type of pattern for intermediate values of the temperature, ion energy, and ion flux. In this type of intermediate morphology, isolated peaks with rectangular cross-sections stand above a landscape of shallow, rounded basins. We also extend past theoretical work to include a second-order correction term that comes from the curvature dependence of the sputter yield. For a range of parameter values, the resulting continuum model of the surface dynamics produces patterns that are remarkably similar to the intermediate morphologies we observe in our experiments. The formation of the isolated peaks is the result of a term that is not ordinarily included in the equation of motion, a second-order correction to the curvature dependence of the sputter yield.

Published by the American Physical Society
2024
Surveying the mass spectra and the electromagnetic properties of the
Ξc(′,*)D(*)
molecular pentaquarks
Authors: Wang Fu-Lai , Liu Xiang
Published: January 2024

Motivated by the observed PψsΛ(4459)/PψsΛ(4338) and Tcc(3875)+ states as the ΞcD¯*/ΞcD¯ and DD* molecular candidates, respectively, in this work we investigate the Ξc(′,*)D(*) molecular systems. We obtain the mass spectra and the corresponding spatial wave functions of the Ξc(′,*)D(*)-type double-charm molecular pentaquark candidates with single strangeness, where we utilize the one-boson-exchange model and take into account both the S−D wave-mixing effect and the coupled-channel effect. Our results show that the most promising candidates of the double-charm molecular pentaquarks with single strangeness include the ΞcD state with I(JP)=0(1/2−), the Ξc′D state with I(JP)=0(1/2−), the ΞcD* states with I(JP)=0(1/2−,3/2−), the Ξc*D state with I(JP)=0(3/2−), the Ξc′D* states with I(JP)=0(1/2−,3/2−), and the Ξc*D* states with I(JP)=0(1/2−,3/2−,5/2−). To gain further insight into the inner structures and the properties of the isoscalar Ξc(′,*)D(*) molecular candidates, we utilize the constituent quark model to analyze their M1 radiative decay behaviors and magnetic moments based on the obtained mass spectra and spatial wave functions, which can offer significant information to determine their spin-parity quantum numbers and configurations in the forthcoming experiments. We suggest that our experimental colleagues search for the predicted Ξc(′,*)D(*) molecular states.

Published by the American Physical Society
2024
Double distributions and pseudodistributions
Authors: Radyushkin A. V.
Published: January 2024

We describe the approach to lattice extraction of generalized parton distributions (GPDs) that is based on the use of the double distribution (DD) formalism within the pseudodistribution framework. The advantage of using DDs is that GPDs obtained in this way have the mandatory polynomiality property, a nontrivial correlation between x and ξ dependences of GPDs. Another advantage of using DDs is that the D-term appears as an independent entity in the DD formalism rather than a part of GPDs H and E. We relate the ξ dependence of GPDs to the width of the α profiles of the corresponding DDs and discuss strategies for fitting lattice-extracted pseudodistributions by DDs. The approach described in the present paper may be used in ongoing and future lattice extractions of GPDs.

Published by the American Physical Society
2024
Freezing-in gravitational waves
Authors: Ghiglieri Jacopo , Schütte-Engel Jan , Speranza Enrico
Published: January 2024

The thermal plasma in the early Universe produced a stochastic gravitational wave (GW) background, which peaks today in the microwave regime and was dubbed the cosmic gravitational microwave background (CGMB). In previous works, only single graviton production processes that contribute to the CGMB have been considered. Here, we also investigate graviton pair production processes and show that these can lead to a significant contribution if the ratio between the maximum temperature and the Planck mass, Tmax/mp, divided by the internal coupling in the heat bath is large enough. As the dark matter freeze-in production mechanism is conceptually very similar to the GW production mechanism from the primordial thermal plasma, we refer to the latter as “GW freeze-in production.” We show that quantum gravity effects appear in single graviton production and are smaller by a factor (Tmax/mp)2 than the leading order contribution. In our work, we explicitly compute the CGMB spectrum within a scalar model with quartic interaction.

Published by the American Physical Society
2024
Flowing from relativistic to nonrelativistic string vacua in
AdS5×S5
Authors: Fontanella Andrea , Nieto García Juan Miguel
Published: January 2024

We find the connection between relativistic and nonrelativistic string vacua in AdS5×S5 in terms of a free parameter c flow. First, we show that the famous relativistic BMN vacuum flows in the large c parameter to an unphysical solution of the nonrelativistic theory. Then, we consider the simplest nonrelativistic vacuum, found in Fontanella and García [] (called BMN-like), and we identify its relativistic origin, namely a noncompact version of the folded string with zero spin, ignored in the past due to its infinite energy. We show that, once the critical closed B-field required by the nonrelativistic limit is included, the total energy of such relativistic solution is finite, and in the large c parameter it precisely matches the one of the BMN-like string. We also analyze the case with spin in the transverse anti–de Sitter directions.

Published by the American Physical Society
2024
Accurate reaction-diffusion limit to the spherical-symmetric Boltzmann equation
Authors: Heizler Shay I. , Krief Menahem , Assaf Michael
Published: January 2024

We resolve a long-standing question regarding the suitable effective diffusion coefficient of the spherical-symmetric transport equation, which is valid at long times. To that end, we generalize a transport solution in three dimensions for homogeneous media, to include general-collisional properties, including birth-death events and linearly anisotropic scattering. This is done by introducing an exact scaling law relating the Green's function of the pure-scattering case with the general-collision case, which is verified using deterministic and Monte Carlo simulations. Importantly, the effective diffusion coefficient is identified by inspecting the transport solution at long times.

Published by the American Physical Society
2024
2-{3-Methyl-2-[(2Z)-pent-2-en-1-yl]cyclopent-2-en-1-ylidene}-N-phenylhydrazinecarbothioamide. Corrigendum
Authors: Oliveira Adriano Bof de , Bresolin Leandro , Beck Johannes , Daniels Jörg
Published: January 2024

In the paper by Oliveira et al. [IUCrData (2023), 8, x230971], there was an error in the name of the first author.
Toward a future discourse on global value chains
Authors: Pushp Pushkar , Ahmed Faisal
Published: January 2024

Purpose

The discourse on global value chains (GVC) is undergoing a transformation in terms of its conceptualisation, theorisation and pragmatic applications. Today, the production systems have become more complex as global economic order continues to witness marked geo-economic manoeuvring. Thus, the direction of discourse on GVC ought to move from mere theoretical propositions toward becoming more evidence based. There have been recent studies that have used the governance and upgrading propositions by Gary Gereffi and others to seek quantitative evidence. This study aims to decipher the quantitative discourse on GVC and to set the emerging and future research agenda.

Design/methodology/approach

Through a systematic literature review, the authors first analyse the quantitative studies on GVC carried out during the last two decades. The authors then outline a future research agenda and examine a few relevant modelling techniques that could potentially be used to solicit newer evidence in GVC research.

Findings

The authors categorise the quantitative discourse on GVC into three crucial themes, namely, GVC framework, GVC participation and position, environmental aspects and regionalisation in GVC. The most commonly used quantitative techniques are gravity model, panel data estimation, structural decomposition analysis and computable general equilibrium modelling.

Originality/value

This paper contributes to the GVC discourse in two ways. Firstly, the authors argue that the theoretical frameworks within the GVC discourse should be complemented by evidence-based quantitative studies. Secondly, the authors suggest potential modelling techniques that can be used on the emerging and future research agenda.
A pulsed bipolar current-mode power supply with high power factor in a single stage for dielectric barrier discharge application
Authors: Tang Xiongmin , Zhou Zexin , Chen Yongquan , Lin ZhiHong , Zhang Miao , Li Xuecong
Published: January 2024

Purpose

Dielectric barrier discharge (DBD) is widely used in the treatment of skin disease, surface modification of material and other fields of electronics. The purpose of this paper is to design a high-performance power supply with a compact structure for excimer lamps in electronics application.

Design/methodology/approach

To design a high-performance power supply with a compact structure remains a challenge for excimer lamps in electronics application, a current-source type power supply in a single stage with power factor correction (PFC) is proposed. It consists of an excitation voltage generation unit and a PFC unit. By planning the modes of the excitation voltage generation unit, a bipolar pulse excitation voltage with a high rising and falling rate is generated. And a high power factor (PF) on the AC side is achieved by the interaction of a non-controlled rectifier and two inductors.

Findings

The experimental results show that not only a high-frequency and high-voltage bipolar pulse excitation voltage with a high average rising and falling rate (7.51GV/s) is generated, but also a high PF (0.992) and a low total harmonic distortion (5.54%) is obtained. Besides, the soft-switching of all power switches is realized. Compared with the sinusoidal excitation power supply and the current-source power supply, the proposed power supply in this paper can take advantage of the potential of excimer lamps.

Originality/value

A new high-performance power supply with a compact structure for DBD type excimer lamps is proposed. The proposed power supply can work stably in a wide range of frequencies, and the smooth regulation of the discharge power of the excimer lamp can be achieved by changing the switching frequency. The ideal excitation can be generated, and the soft switching can be realized. These features make this power supply a key player in the outstanding performance of the DBD excimer lamps application.
Library management models: a review and direction for future research
Authors: Hussain Abid , Khan Amjid , Ahmad Pervaiz
Published: January 2024

Purpose

As a part of doctoral study, this study aims to analyze research on library management models (LMMs) by conducting a systematic literature review (SLR).

Design/methodology/approach

A Preferred Reporting Items for Systematic Review and Mata-Analysis approach was used to search four databases. The search criteria included studies published in English until 2022, resulting 9,125 records. Out of these records, a total of 36 studies were selected for final analysis

Findings

The results show a positive attitude among researchers toward the development of LMM for libraries globally. The results depict that more than one-third (39%) of the target population was comprised of academic staff and students. The majority (91.76%) of studies were conducted using survey. Quantitative methods were predominant (89%) for LMMs. There were a significant number of studies conducted in 2016. The country-wise distribution shows the USA and China each contribute (20%) of the studies.

Practical implications

The findings of this research could assist policymakers and authorities in reconciling the LMMs applied in libraries for providing efficient access to information resources and services to end users.

Originality/value

To the best of the authors’ knowledge, this study is unique as no comprehensive study has been conducted on LMMs using the SLR method.
Gaining customer engagement in social media recovery: the moderating roles of timeliness and personalization
Authors: Honora Andreawan , Wang Kai-Yu , Chih Wen-Hai
Published: January 2024

Purpose

This research investigates the role of customer forgiveness as the result of online service recovery transparency in predicting customer engagement. It also examines the moderating roles of timeliness and personalization in this proposed model.

Design/methodology/approach

An online survey study using retrospective experience sampling and a scenario-based experimental study were conducted to test the proposed hypotheses.

Findings

Customer forgiveness positively influences customer engagement and plays a mediating role in the relationship between service recovery transparency and customer engagement. Additionally, timeliness and personalization moderate the positive influence of service recovery transparency on customer forgiveness. The positive influence of service recovery transparency on customer forgiveness is more apparent when levels of timeliness and personalization decrease.

Practical implications

To retain focal customers' engagement after a service failure, firms must obtain their forgiveness. One of the firm's online complaint handling strategies to increase the forgiveness level of focal customers is to provide a high level of service recovery transparency (i.e. responding to their complaints in a public channel), especially when the firm is unable to respond to online complaints quickly or provide highly personalized responses.

Originality/value

This research provides new insights into the underlying mechanism of customer engagement by applying the concept of customer forgiveness. It also contributes to the social influence theory by applying the essence of the theory to explain how other customers' virtual presence during the online complaint handling influences the forgiveness of focal customers in order to gain their engagement. Additionally, it provides insight into the conditions under which the role of service recovery transparency can be very effective in dealing with online complaints.
Prospects of crop insurance for sustenance of farmers' livelihood during GM cotton crop failure in Indian Punjab
Authors: Kaur Sandeep , Singh Harpreet , Roy Devesh , Singh Hardeep
Published: January 2024

Purpose

Despite the susceptibility of cotton crops to pest attacks in the Malwa Region of Indian Punjab, no crop insurance policy has been implemented there– not even the Pradhan Mantri Fasal Bima Yojana (PMFBY), which is a central scheme. Therefore, this paper attempts to gauge the likely impact of the PMFBY on Punjab cotton farmers and assess the changes needed for greater uptake and effectiveness of PMFBY.

Design/methodology/approach

The authors have conducted a primary survey to conduct this study. Initially, the authors compared the costs of cotton production with the returns in two scenarios (with and without insurance). Additionally, the authors have applied a logistic regression framework to examine the determinants of the willingness of farmers to participate in the crop insurance market.

Findings

The study finds that net returns of cotton crops are conventionally small and insufficient to cope with damages from crop failure. Yet, PMFBY will require some modifications in the premium rate and the level of indemnity for its greater uptake among Punjab cotton farmers. Additionally, using the logistic regression framework, the authors find that an increase in awareness about crop insurance and farmers' perceptions about their crop failure in the near future reduces the willingness of the farmers to participate in the crop insurance markets.

Research limitations/implications

The present study looks for the viability of PMFBY in Indian Punjab for the cotton crop, which can also be extended to other crops.

Social implications

Punjab could also use crop insurance to encourage diversification in agriculture. There is a need for special packages for diversified crops under any crop insurance policy. Crops susceptible to volatility due to climate-related factors should be identified and provided with a special insurance package.

Originality/value

There exist very scant studies that have discussed the viability of a central crop insurance scheme in the agricultural-rich state of India, i.e. Punjab. Moreover, they do not also focus on crop losses accruing due to pest and insect attacks.