bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation on the Influence of Color Presentation on Learning Environment
Authors: Cong Miao
Published: January 2025

This paper aims to explore the impact of color presentation on the learning environment, especially its effect on cognitive load. The research background section introduces the definition of the physical learning environment and its importance in online and traditional classrooms. Through literature review, this paper clarifies the potential effects of color presentation on cognitive load in different learning environments and points out the shortcomings of existing studies. In this paper, a structural equation model is designed to analyze the relationship between classroom light source, brightness, ceiling height, equipment situation, electronic equipment resolution, brightness and color environment and multimedia color presentation. The research methods section describes the experimental design, participant selection criteria, and data collection process in detail. The research order and the experiment order of this paper systematically show the whole process from literature review to data analysis. The results of this study will provide a theoretical basis for optimizing the color design in the teaching environment to reduce the cognitive load of students and improve the learning effect.
Fear/Anxiety and Sleep Deprivation Combine to Predict Courage
Authors: Gibbons Jeffrey Alan , McManus Brenna E. , White Ella C. , Gibbons Akihaya Mochizuki
Published: January 2025

The current study examined the combined effects of sleep deprivation and anxiety on participants' willingness to act courageously in both heroic and everyday situations. Participants consisted of 256 undergraduate students between the ages of 18 to 25 years old seeking regular and extra credit for their psychology classes through SONA. Following informed consent, participants completed demographic questionnaires through Qualtrics, as well as the Depression Anxiety Stress Scale, the Pittsburgh Sleep Quality Index, and a version of the Woodard Pury Courage Scale-23 (WPCS-23). The Woodard Pury Courage Scale-23 measures participants’ willingness to engage in challenging tasks that require either heroic or everyday courage
and the fear they would experience when engaging in these tasks. The 6 measures of courage included willingness to engage in everyday, heroic, and both acts, as well as fear when engaging in these actions. Fear/anxiety by sleep interactions predicted every courage measure with the exception of fear when engaging in daily courageous actions. The results supported the hypothesis that fear/anxiety and poor sleep would combine to predict courage, and their implications are discussed.
Generalized RIF Regressions
Authors: Alejo Javier , Galvao Antonio , Martínez-Iriarte Julián , Montes-Rojas Gabriel
Published: January 2025

This paper suggests a generalization of covariates shifts to study distributional impacts on inequality and distributional measures. It builds on the recentered influence function (RIF) regression method designed for location shifts on covariates, but it extends to general policy interventions such as location-scale or asymmetric interventions. Numerical simulations for Gini, Theil and Atkinson indexes show it has a very good performance on a myriad of cases and distributional measures. An empirical application to studying changes in Mincerian equations illustrates the method.
3D Dynamic Trajectory Planning for Autonomous Underwater Robots under the PPO-IIFDS Framework
Authors: Liu Liqiang , Sun Min , Zhao Enjiao , Zhu Kuang
Published: January 2025

Three-dimensional (3D) dynamic trajectory planning for Autonomous Underwater Vehicles (AUV) poses significant challenges in balancing trajectory quality, computational efficiency, and environmental adaptability within complex dynamic environments. To tackle these challenges, this paper proposes a novel trajectory planning framework by integrating Proximal Policy Optimization (PPO) and an Improved Interfered Fluid Dynamic System (IIFDS). The IIFDS serves as the planning layer, generating obstacle-adaptive trajectories for AUVs through dynamic adjustment of flow field parameters. Meanwhile, PPO functions as the learning and decision-making layer, optimizing critical parameters in IIFDS, including repulsion response coefficients, tangential response coefficients, and directional coefficients, to enhance adaptability and real-time decision-making. To meet specific mission requirements, the IIFDS incorporates dynamics and kinematics constraints, while the PPO reward function is improved with a multi-objective dynamic structure. This reward design integrates objectives such as obstacle avoidance, target distance minimization, trajectory smoothness, dynamics constraints, and energy efficiency. These enhancements address sparse reward issues effectively and significantly improve the convergence and practical applicability of trajectory planning. Additionally, a diverse and dynamically complex obstacle environment is constructed for model training and performance evaluation. Experimental results demonstrate that the proposed framework efficiently generates smooth, energy-efficient, and collision-free trajectories in high-density dynamic obstacle scenarios. The framework exhibits strong robustness, excellent generalization capabilities, and offers a reliable solution for 3D dynamic trajectory planning for AUV.
Genome Sequence, Comparative Genome Analysis and Expression Profiling of Chitinase GH18 Gene Family in Cordyceps javanica Bd01
Authors: Zhu Tao , Hussain Mehboob , Ning Jingyi , Chen Xiao , Shi Chunlan , Yang Dewei , Gao Xi , Wu Guoxing
Published: January 2025

The fungus Cordyceps javanica is known for entomopathogenicity and effective in control of various arthropods. Here, we aimed to reveal chitinase GH18 gene family expansion through high put sequencing of genome of C. javanica strain Bd01 isolated from Xylotrechus quadripes larvae. The genome was 34 Mb in size with 9,590 protein-coding genes. By comparative genome analysis, it was found that family GH18 of chitinase genes was expanded in C. javanica Bd01. Phylogenetic analysis of twenty-seven GH18 genes with those of 4 other species showed that genes were clustered into three groups based on their conserved domains. The GH18 genes clustered in same group had the same protein motifs and orthologs. The molecular mass of GH18 genes varied from 14.03 kDa - 81.41 kDa, and theoretical pI from 4.40 - 7.92. Most of the chitinases were extracellular, hydrophilic, thermostable and negatively charged with good in vivo half-life. Furthermore, a three-dimensional model of GH18 was constructed using SWISS-MODEL server. These findings provide comprehensive insights into pathogenicity-related genes, their role and conservatism.
Data-driven Analysis on the Causal Chain of Waterborne Traffic Accidents: a hybrid framework based on the improved HFACS and Bayesian Network
Authors: Yin Xiangyu , Yan Yan , Wang Jiahao , Zhao Hongzhuan , Wu Qingyan , Xu Qi
Published: January 2025

In the context of economic globalization, waterborne transportation plays an important role in international trade and logistics. However, the occurrence of waterborne traffic accidents poses a severe threat to life, property safety, and the environment. To gain a deeper understanding of the causal mechanisms behind waterborne traffic accidents, this study conducts a data-driven analysis on the causal chain of waterborne traffic accidents. By constructing a hybrid framework integrating the improved HFACS (Human Factors Analysis and Classification System) with Bayesian Network model, the study conducts a multi-dimensional analysis of accident causes. The constructed model is quantitatively analyzed using genie software by the accident samples collected from China MSA. Results indicate that there are 12, 3, 6, 2, 4, and 7 causal chains leading to collisions, contacts, fire/explosion, windstorms, sinking, and other types of accidents respectively. The research results can provide a reference for the enhancement on the safe operation of waterborne transportation.
Green Hydrogen Generation by Water Photoelectrolysis: Economic and Environmental Analysis
Authors: Maggio Gaetano , Vasta Salvatore , Nicita Agatino , Trocino Stefano , Giorgianni Mauro
Published: January 2025

Water photoelectrolysis cells based on photoelectrochemical water splitting seem to be an interesting alternative to other traditional green hydrogen generation processes (e.g. water electrolysis). Unfortunately, the practical application of this technology is currently hindered by several difficulties: low solar-to-hydrogen (STH) efficiency, expensive electrode materials, etc. A novel concept, based on a tandem photoelectrolysis cell configuration with an anion-conducting membrane separating the photoanode from the photocathode, has already been proposed in the literature. This approach allows the use of low-cost metal oxide electrodes and nickel-based co-catalysts. In this paper, we conducted a study to evaluate the economic and environmental sustainability of this technology, using the environmental life cycle cost. Preliminary results have revealed two main interesting aspects: the negligible percentage of externalities in the total cost, which means a positive environmental impact; as evidenced by the net present value (NPV), there are potentially financial conditions that favour future investment.
Artificial Intelligence in Road Transportation: Opportunities and Challenges for Carbon Emission Reduction
Authors: Ighravwe Desmond Eseoghene , Olanrewaju Oludolapo Akanni , Babatunde Olubayo Moses
Published: January 2025

This study discussed the nexus between Artificial Intelligence (AI) and carbon emissions in road transportation. It highlighted AI’s potential as a promising tool for carbon footprint management in this sector. The study considered different carbon emission reduction strategies, such as fuel consumption optimization, speed management, traffic control systems, and vehicle fleet policies. This study acknowledged AI’s emerging roles in providing real-time information, reducing implementation costs, and minimizing human bias in road traffic control and emission monitoring. In this study, it was observed that different AI algorithms, such as artificial neural networks and support vector machines have been used for traffic management and CO2 emission prediction. This study reported the growing global market for AI technologies in transportation due to its potential to analyse historical data and optimize various aspects of transportation systems. However, several challenges affect AI adoption in this sector. This includes limited information on how to manage data quality and availability in the industry, issues of system failures and cyber-attacks, lack of trust, and fear of job displacement that are associated with AI adoption in the transportation sector. The study further provided insights into the complexity of integrating AI into this sector's operations. Lastly, this study acknowledged the need for continued research on AI in the transport sector, while acknowledging the need for more investment in AI and robust policy development in order to sustain an efficient transportation system.
The First Digital Strategy-Based Training of Executive Functions: Impact on Cognition, Behavioral and Emotional Regulation, and Academic Success in Both Typically Developing Children and Children at Psychosocial Risk
Authors: Cáceres-González David , Rossignoli-Palomeque Teresa , Rodríguez María Vaíllo
Published: January 2025

STap2Go is the first pure digital strategy-based training of executive functions. This study aims to assess the effectiveness of this intervention in typically developing children and those at psychosocial risk, which refers to socio-educational vulnerability. Additionally, we determine whether the training’s impact differs between these groups. One hundred and twenty-four children aged 9–12 participated in this study. They were divided into typically developing children or those at psychosocial risk and randomly assigned to either the experimental or active control group. Each group received a 12- week intervention. Both experimental groups improved significantly in EF, processing speed, IQ, academic performance, and emotional regulation compared to the control groups. The experimental group of children at psychosocial risk also improved in metacognition and behavioral regulation compared to controls. Overall, no significant differences were found between the experimental groups. Notably, participants in the psychosocial risk control group exhibited a certain deterioration over time.
Impact of Sucrose Consumption During Pregnancy on the Metabolic, Immune and Redox Profile in Females with Gestational Diabetes Mellitus
Authors: Rosales-Gómez Cristian Angel , Martinez-Carrillo Beatriz Elina , Guadarrama-López Ana Laura , Reséndiz-Albor Aldo Arturo , Arciniega-Martínez Ivonne Maciel , Aguilar-Rodríguez Efrén
Published: January 2025

Carbohydrate consumption during pregnancy represents an important source of energy for the mother-child duo; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increases glucose transport to the fetus, adiposity and the risk of macrosomia. The objective was to research the impact of sucrose consumption during pregnancy on the metabolic, immune and Redox profile in females with GDM. 24 female CD1 mice were used, they were divided into two groups: Control and DMG. Each group was subdivided into 2 subgroups: a) Without Sucrose and b) With Sucrose. The following were determined: Body Mass Index (BMI), Glycaemia, hormones (insulin, adiponectin and leptin), CD3+ T lymphocytes, cytokines (IL-1β, IL-6, IFN-γ and TNF-α), IgA and IgG antibodies, as well as Redox systems. The Sucrose consumption increases HOMA-IR and the secretion of insulin, adiponectin and leptin, it also increased the secretion of proinflammatory cytokines and the production of IgA and IgG antibodies, decreased the activity of the Glutathione Reductase enzyme and increased the production of TBARS and AGE. High sucrose consumption increases the inflammatory response mediated mainly by CD8+ lymphocytes and the production of proinflammatory cytokines, it can trigger a compensatory humoral response and alter Redox mechanisms causing a state of Oxidant Stress.
Kidney Disease Patients on Hemodialysis Who Present Anemia
Authors: Perez Carlos , Sanchez Jose Daniel
Published: January 2025

Anemia in advanced chronic kidney disease on hemodialysis patients is a very prevalent problem , and it is well known that the treatment of this type of anemia is through the use of erythropoiesis-stimulating agents (erythropoietin). However, there are factors that determine a low response to erythropoietin (hyporesponse), which is defined as the need for doses greater than 200 IU/KG/week of erythropoietin to maintain objective hemoglobin levels in patients on hemodialysis, which are between 10 g/ dl to 12 g/dl.(22) In this observational study, analytical, multicenter case-control study, which included 784 patients, the prevalence of hyporesponse was 15.69%. It was found that female sex, age less than 50 years, a BMI less than 23 kg/m² and the use of Renin Angiotensin system blockers presented a higher prevalence of hyporesponse to treatment with EPO. Regarding laboratory parameters, it was found that low albumin levels, high ferritin levels, transferrin saturation less than 20% and high parathormone levels are risk factors associated with hyporesponsiveness to EPO.
A Comparative Sensory Analysis on Consumers’ Preferences for Fermented vs Acidified Sea Fennel Preserves
Authors: Ozturk Emel , Mandolesi Serena , Naspetti Simona , Maoloni Antonietta , Aquilanti Lucia , Zanoli Raffaele
Published: January 2025

Sea fennel (Crithmum maritimum L.), a marine vegetable, has been gaining attention for its potential uses in food, medicine, and crop protection. Although numerous studies have recently focused on its chemical composition and promising functional food properties, consumer perception remains underexplored. The present study aimed to investigate the consumer acceptance of the sea fennel preserves in Italy, including fermented and acidified versions, assessed in blind, expected, and actual conditions. Physicochemical analyses revealed that vinegar acidification resulted in a lower pH compared to lactic acid fermentation. In blind conditions, tasting without information, participants liked fermentation more than acidification with female graduated participants and active workers rating it higher. The results suggest that introducing fermented sea fennel preparations to the market will likely appeal to ‘adventurous women’ with higher education and employment. Future studies should focus on communication strategies that aim to improve product familiarity, the nutritional and health attributes, and the culinary uses of the product.
Access to Vaccines in Floodplains and Hard-to-Reach Areas of the Brazilian Amazon: The Contribution of Street-Level Bureaucrats and the Use of Social Technologies
Authors: de Lima Jair Araujo , Neta Anizia Aguiar , Assis Suze Mary Camurça , Rodrigues Bruno de Oliveira , Ribeiro Helena
Published: January 2025

Introduction: Access to vaccines provided by the Brazilian National Immunization Program (NIP) by populations living in floodplains and hard-to-reach areas of the Amazon is complex and conditioned by the geographic characteristics of the region. The success of vaccination campaigns requires different strategies, technologies and the involvement of professionals whose work involves going beyond standard operating procedures and vaccination protocols. Objective: To describe the specificities of access of populations living in floodplain areas and hard-to-reach areas located within the geographic perimeter of the municipality of Careiro da Várzea, in the state of Amazonas, Brazil, to vaccines made available by the Imuniza SUS Program. Methods: Case study using qualitative-descriptive techniques that combined data analysis, document analysis, and participant observation to reveal different socio-sanitary aspects of the immunization process of the Amazonian populations studied. The concepts of Street Level Bureaucracy and Social Technologies guided the analysis and description of the immunization process in the area studied. Results: The study made it possible to describe the geographic conditions, the social technologies used, and the actors involved in the immunization process of the populations of communities and villages in flooded areas of the Amazon in Brazil. The high temperatures in the region create the need for thermal control in the storage of vaccines during their transfer to the communities and villages. The local coordination of the Imuniza SUS Program acts as a strategic mediator between the different bodies, ensuring the population's access to vaccines, which means that the actions of government agents (street-level bureaucracy) are crucial to the functioning of the immunization program. Conclusion: The success of the immunization campaigns in the hard-to-reach flooded areas of the municipality is due to the existence of a virtuous cycle arising from the synergy between the different actors that make up the immunization service; there is a clear relationship between the vaccination coverage rates achieved and the municipal administration's commitment to public health; the immunization rates achieved in the municipality studied were compatible with the average established by the Brazilian Ministry of Health.
Risk Factors Associated to Poor Survival in Primary Breast Cancer of Premenopausal and Postmenopausal Patients: A Mexican-Based Population Study
Authors: Rocha López Angélica Georgina , Gómez-García Anel , Montecillo-Aguado Mayra , Sánchez-Ceja Sandra Guadalupe , Huerta-Yepez Sara , Gutiérrez-Castellanos Sergio
Published: January 2025

Background. Breast cancer (BC) is the most prevalent neoplasm in the female gender, being also the leading cause of mortality in women worldwide. In Latin American countries such as Mexico, locally advanced and metastatic stages remain prevalent at the time of diagnosis. Factors involved in the progression of BC are highly interdependent elements, where non-modifiable risk factors, such as premenopausal and menopause play a significant role in BC prognosis[SG1] .Methods. Retrospective cohort study that analyzed clinicopathological variables of 292 cases of BC evaluating individual risk within premenopausal and postmenopausal women and probability of survival with a 5-year median follow-up.Results. Our results showed that overall survival (OS) rate for premenopausal and postmenopausal women at 5-years was 88.1% and 92.6%, respectively. Premenopausal showed over 3.6-fold increased risk of recurrence at early stages (p=0.0003), and decreased OS associated to larger tumors (>2 cm) (p=0.0290; HR 4.54; 95%CI 1.58-13.07). In postmenopausal women, we observed a significant effect on OS associated to negative estrogen receptor (ER–) status tumors (p=0.0014; HR 3.71; 95%CI 1.21-11.39), and Triple Negative (TN) subtype (p=0.0021; HR 4.72; 95%CI 1.05-21.28). These findings show differences between cohorts and briefly informs prognosis by menopausal status in a Mexican population-based study, in hopes of improved prevention and detection programmes.
Digitalisation to Improve Automated Agro-Export Logistics: Comprehensive Bibliometric Analysis
Authors: Cortez Clavo Luis Kevin , Muñoz Maryorie Irania Salazar , Santamaría Rogger Orlando Morán
Published: January 2025

Digitalisation in logistics transcended in the search for continuous improvement of good process optimisation. This study aims to determine the effectiveness of the digitalisation implemented by companies to improve the automated logistics of cross-border trade in the agricultural sector. The research methodology was generated through a bibliometric analysis, exploring the evolution of the state of the art through the Scopus, WOS and Dimensions databases, in order to select relevant empirical studies on digitalisation and automated logistics, using quality criteria and the application of the Prisma flowchart. The results highlighted that since 2017 there have been signs of increased interest from researchers, with authors such as Zoubek, Kumar and Ghobakhloo standing out. This review revealed how digitalisation contributes to the optimisation of costs and time in the logistics chain. Designing public policies allows for a better integration of technology, such as IoT and AI. Three important blocks were identified that have contributed to the effectiveness of digitalisation in automated logistics: ‘Impact of digitalisation on logistics efficiency and the supply chain’, ‘Technological integration and automation in cross-border logistics’ and ‘Governance, policies and social considerations in logistics digitalisation’. The conclusions reached were that digitalisation has been a fundamental element in improving logistics and making it autonomous within cross-border trade, allowing technology to become involved, integrating digital technologies such as artificial intelligence (AI), which reduced obstacles affecting the supply chain.
Pregestational Stress Representing a Maternal Depression Model and Prenatally Applied Antidepressant Mirtazapine Modulate Hippocampal Excitability in the Offspring
Authors: Dubiel-Hoppanova Lucia , Filipova Alzbeta , Bukatova Stanislava , Ondacova Katarina , Tomko Matus , Jurkovicova-Tarabova Bohumila , Dubovicky Michal , Dremencov Eliyahu , Lacinova Lubica
Published: January 2025

Maternal depression negatively affects the neurodevelopment of offspring, but its pharmacological treatment during gestation remains controversial. This study reports the consequences of maternal depression and/or prenatal antidepressant treatment with mirtazapine on offspring early neurodevelopment via an animal model of maternal depression induced by pregestational chronic unpredictable stress (CUS). Offspring from four groups were studied: nonstressed vehicle-treated dams, nonstressed mirtazapine-treated dams, stressed vehicle-treated dams, and stressed mirtazapine-treated dams. The hippocampal excitability of offspring was examined in primary hippocampal cultures established on the first postnatal day, reflecting mostly prenatal development, and in hippocampal slices prepared on postnatal days 11-13 reflecting an early postnatal development. Pregestational CUS modeling of maternal depression moderately suppressed offspring hippocampal excitability in primary cultures but facilitated it in slices. Mirtazapine administered to CUS-exposed dams partly rectified the changes observed in primary cultures of pups from untreated dams and, more prominently, in slices. Mirtazapine itself negatively affected the hippocampal excitability of nonstressed dam offspring in primary culture, and this effect was diminished in slices. Since altered hippocampal neurotransmission might be responsible, at least in part, for the neuropsychopathologies frequently observed in the offspring of depressed mothers, and mirtazapine was able partly relieve such changes, this treatment may be also beneficial during the prenatal and perinatal periods.
Waning Trends in Prevalence and Intensity of Wuchereria bancrofti Transmission Over Ten Chemotherapy Rounds in Ghana
Authors: Osei Joseph Harold Nyarko , Pi-Bansa Sellase , Quartey Joseph , Otchere Joseph , Kartey-Atipoe Worlasi Debi , Frempong Kwadwo Kyereme , Donkor Irene Owusu , Ahorlu Collins , Appawu Maxwell Alexander , Kwansa-Bentum Bethel , Aboagye-Antwi Fred , Bimi Langbong , Wilson Michael David , de Souza Dziedzom Komi , Dadzie Samuel Kweku , Boakye Daniel Adjei
Published: January 2025

Ghana’s lymphatic filariasis (LF) elimination was intensified by Global Programme to Eliminate Lymphatic filariasis in 2000. LF transmission was interrupted in some endemic district, yet, persistent in others. This study investigated some characteristics of Wuchereria bancrofti that potentially contribute to persistent LF transmission in Ghana’s endemic districts after prolonged mass chemotherapy (≧15yrs) expected to interrupt transmission. Participants’ finger-prick blood was screened for antigenaemia and positives followed for night blood to detect microfilariae. The antigenaemia/microfilaraemia prevalence, implications of W. bancrofti transmission, and microfilariae clearance using scoring method (SM) were assessed. Exactly 2973 individuals were screened for antigenaemia and 33 found positive. Infected individuals were followed for night blood to detect microfilaraemia in 8 communities from the 4 study districts. The antigenaemia/microfilaraemia prevalence in Antseambua, Asemkow, Badunu, Navio (Sanwu) Central, Atampiisi Bongo, and Balungu Nabiisi were 1.3/0.0, 0.8/0.3, 0.8/0.0, 1.2/0.0, 1.7/0.0, and 3.1/0.9 respectively but none in Ampeasem and Obrayebona. Microfilariae density for thick blood films/Sedgwick counts was relatively higher in Western Region (283.9/410.0) compared to Upper East Region (44.5/25.0). Microfilariae clearance/reinfection was observed (using SM). Currently, prevalence thresholds suggest competent vectors can sustain LF transmission in Ahanta West District (hotspot) and cause possible reinfection/resurgence in Bongo (control district).
Prevalence of Upper Gastrointestinal Symptoms and Gastric Dysrhythmias in Diabetic and Nondiabetic Indian Population: A Real-World Retrospective Analysis from Electrogastrography Data
Authors: Bandyopadhyay Sanjay , Kolatkar Ajit
Published: January 2025

Background: Upper gastrointestinal (GI) motility disorders, such as gastroparesis and functional dyspepsia (FD), contribute significantly to morbidity, especially in populations at risk for type 2 diabetes. However, the prevalence and clinical manifestations of these disorders in India and associated gastric dysrhythmias are not well-studied within this population. Methods: A retrospective, cross-sectional study was conducted, analysing 3,689 patients who underwent electrogastrography with water load satiety test (EGGWLST) testing across multiple motility clinics in India. The prevalence of gastroparesis and FD-like symptoms, symptom severity, and their association with diabetes and other comorbidities were evaluated. Symptom severity was assessed using the Gastroparesis Cardinal Symptom Index (GCSI) and EGGWLST findings were documented including the Gastric myoelectric activity threshold (GMAT) scores. Results: The study population had a mean age of 43.18 years. GCSI scores indicated mild symptoms (55%), moderate (33%), and severe (8%). As compared to non-diabetic population diabetic subjects had significantly higher rates of early satiety (56% vs. 45%, p<0.0001), bloating (73% vs. 67%, p 0.005), and reflux (28% vs. 24%, p 0.029) while WLST data analysis revealed that significantly more diabetic subjects ingested <350ml (16% vs 12%, p 0.000016). EGG analysis revealed gastric dysthymias in 1/3rd (65%). Significantly more diabetic subjects (22% vs 18% p 0.015) had a >0.59 GMAT score. Conclusions: Upper GI motility disorders are prevalent in India, particularly among diabetic patients. EGG is a valuable tool for characterising these disorders which may help in appropriating therapeutic approaches. Further research is required to optimize treatment strategies.
Expression Profiles of Five Common Cancer Membrane Protein Antigens Collected for the Development of Cocktail CAR-T Cell Therapies Applicable to Most Solid Cancer Patients
Authors: Nakatsura Tetsuya , Takenouchi Kazumasa , Kataoka Jun , Ito Yusuke , Kikuchi Sae , Kinoshita Hiroki , Ohnuki Kazunobu , Suzuki Toshihiro , Tsukamoto Nobuo
Published: January 2025

Although CD19 CAR-T has been highly effective against B-cell blood cancers, there are few reports of successful treatments for solid cancers, probably because there are few protein antigens specifically expressed on the surface of the cancer cell membrane. The key to developing a groundbreaking CAR-T cell therapy effective against solid cancers is to "overcome the heterogeneity of cancer antigens." For this purpose, it is necessary to target multiple cancer antigens simultaneously. In this study, we performed immunohistochemical analysis of various solid cancer specimens using antibodies against ROBO1, EphB4, CLDN1, and LAT1 in addition to GPC3, which we have previously studied. These antigens were frequently expressed in various solid cancers but shown to be rarely expressed, with some exceptions, in non-cancerous normal organs adjacent to the cancer. In addition, it was revealed that the cell membrane antigens EphB4, CLDN1, and LAT1 are frequently expressed in various solid cancers. CAR-T cell therapy targeting these antigens may be a savior for many solid cancer patients. We will develop cancer immunotherapies that target these multiple common cancer membrane protein antigens.
The Vital Role of Sports Psychology in Preventing Children’s Involvement in Conflict: A Case for Kashmir
Authors: Ahmed Mohd Manshoor
Published: January 2025

Sports psychology, as an interdisciplinary domain, is essential for cultivating psychological resilience and encouraging prosocial conduct among young, especially in conflict-affected areas. This article examines how structured sports programs, combined with psychological concepts, can function as preventive and rehabilitative mechanisms to reduce children's engagement in conflict. By utilizing local cultural affinity for sports such as cricket and integrating global best practices, these programs have effectively diminished aggressiveness, improved emotional well-being, and promoted community cohesiveness. Case studies from Kashmir, in conjunction with worldwide comparisons, highlight the transformative capacity of sports psychology in tackling socio-political difficulties and cultivating a generation adept at navigating intricate circumstances. The article emphasizes governmental and grassroots initiatives to institutionalize sports as a developmental instrument, promoting its extensive implementation and assessment.
TEDDY Framework: An Efficient Framework for Target Tracking Using Edge-Based Distributed Smart Cameras with Dynamic Camera SelectionTEDDY Framework: An Efficient Framework for Target Tracking Using Edge-Based Distributed Smart Cameras with Dynamic Camera Selection
Authors: Yang Jaemin , Lee Jongwoo , Lee Ilju , Lee Yaesop
Published: January 2025

This paper introduces a novel framework for a target tracking system with dynamic resource management using edge-based distributed smart cameras— the TEDDY framework. The proposed framework employs context-aware dynamic camera selection, activating only the cameras most likely to detect the target based on its predicted trajectory. This approach significantly reduces computational load and energy consumption while maintaining high tracking accuracy. Designed for resource-constrained environments, the framework offers a scalable solution for applications such as smart city infrastructure and emergency response systems. The framework was evaluated through two experiments. In the first, single-person tracking was conducted across multiple routes featuring various behaviors such as walking, running, and staggering, demonstrating the framework's effectiveness in optimizing resource utilization. In the second, the framework was applied to a simulated urban traffic light adjustment system for emergency vehicles, achieving significant reductions in computational load while maintaining equivalent tracking accuracy compared to an always-on camera system. These findings highlight the robustness, scalability, and energy efficiency of the TEDDY framework in edge-based camera networks. Furthermore, the TEDDY framework lays the groundwork for future advancements in dynamic resource management and tracking technologies, offering opportunities for integration into larger-scale systems and diverse operational scenarios.
Autonomous Decentralized Cooperative Control DC Microgrids Realized by Directly Connecting Batteries to the Baseline
Authors: Yamada Hirohito
Published: January 2025

Recent years have seen increasing attention on autonomous decentralized microgrids that are disaster-resistant and suitable for local consumption of locally generated renewable energy power. Although various methods have been discussed for achieving microgrids through autonomous decentralized cooperative control, there are few reports that have reached the stage of field testing. In this study, we propose a novel configuration method for DC microgrids, where storage batteries are distributed and directly connected to the DC baseline. We have built a testbed to demonstrate the operation of the DC microgrid through autonomous decentralized cooperative control. Our method simply employs the Droop characteristics inherent in batteries, and we introduce the new concept of a "weakly-coupled grid." This approach allows the realization of microgrids with autonomous decentralized cooperative control without the need for advanced and complex grid control technologies such as that with AI, and with a simple configuration. Additionally, by directly connecting batteries to the baseline, we introduced a grid stabilization method by imparting electrical inertia to the baseline. This paper describes the construction method, the operation principle, and the safe and stable operational methods for autonomous decentralized microgrids using this approach, aiming to serve as a guide for those who wish to build autonomous decentralized controlled microgrids in practice.
TRPV1 Receptor Stimulates Myocardial Protection in Hypertensive Rats Through Regulation of Mitochondrial Function
Authors: Ruíz-Ramírez Angelica , Castrejón-Téllez Vicente , del Valle-Mondragón Leonardo , Pérez-Torres Israel , Guarner-Lans Verónica , Medina-Rodríguez Oralia , Velázquez-Espejel Rodrigo , Vargas-González Álvaro , Flores-Chávez Pedro , Martínez-Memije Raúl , Torres-Narváez Juan Carlos
Published: January 2025

The TRPV1 receptor is expressed on various cell types, including cardiomyocytes. Activation of TRPV1 leads to regulation of Ca²⁺ flux across both cell and mitochondrial membranes, which could control the ion flux under experimental systemic arterial hypertension (SAH), particularly in mitochondria, and thus prevent heart damage. In this study, SAH was induced in male Wistar rats using L-NAME, providing a system in which the regulatory action of nitric oxide (NO) is inhibited. The animals were divided into five groups: 1) Control (C), 2) Hypertensive (H), 3) H+Capsaicin (H+CS), 4) H+Capsazepine (H+CZ), and 5) H+CS+CZ. L-NAME was added to drinking water at a concentration of 200 mg/L for 40 days. Four days before the end of the L-NAME treatment, a daily subcutaneous dose of CS (5 mg/kg in the H+CS group), CZ (6 mg/kg in the H+CZ group), or a combination of CS+CZ was administered. We analyzed mitochondrial function and the damage caused by hypertension in the heart. The activation of TRPV1 under SAH conditions improved mitochondrial respiratory control, regulated oxidative stress, and modulated pro-apoptotic proteins. The improvement in mitochondrial metabolism led to the prevention of damage and better heart function.
"Fostering Public Value through the Open Government Partnership: Challenges and Opportunities for the Digitalization of Tunisian Administration"
Authors: Ben Mansour Khaoula , Ben Kahla Karim
Published: January 2025

This research examines the co-constructive process of public policy in the context of a democratic transition, with a particular focus on access to information. It analyzes the conditions for citizen participation, considering factors such as leadership competition and conflicts of interest between public sector representatives and civil society actors. Additionally, the study explores the influence of institutional mimicry and the role of financial partners in shaping the trajectory of the co-construction process. The research also addresses the challenge of sovereignty in the formulation and implementation of public policy.
Our approach draws upon collaborative action research and discourse analysis, which collectively inform our understanding of public "innovation" as part of the "co-creation" of public policies.
Research Findings and Contributions:
This study identifies two primary paradoxes and tensions within the Open Government Partnership (OGP) program. The first paradox underscores that the co-construction of a national plan often results in the adoption of externally derived solutions, which may be disconnected from the unique institutional contexts of the country. The second paradox reveals that the supposed collaboration among various stakeholders can lead to competitive power dynamics, where civil society gains influence at the expense of the administrative role. Additionally, the research explores the tension between local (municipal) and national levels in the processes of defining and implementing public policy.
Technology and Social Media’s Hidden Cost: Social Dilemma, Mental Health, Misinformation, and Manipulative Practices
Authors: Mamun Quazi
Published: January 2025

The pervasive influence of technology and social media has transformed con- temporary life in unprecedented ways, yet beneath the surface lies a complex web of hidden costs that affect individuals, society, and ethical norms. This paper explores these multifaceted dimensions, illuminating critical issues such as misinformation, mental health implications, and the manipulative practices employed by technology and social media companies while presenting an in-depth analysis of the underlying factors contributing to these developments and the key stakeholders involved. It emphasises the necessity to scrutinise technology design and prevailing business models to ascertain their roles and responsibilities in shaping the ethical utilisation of innovative services, addressing the ethical dilemmas arising from data usage, privacy considerations, and the influence of persuasive technologies designed to capture user attention. Additionally, the rising prevalence of mental health challenges among adolescents in the social media era, the integration of advanced technologies, and the real-world consequences of weaponised social media are examined. Ultimately, the paper offers practical strategies to manage the influence of technology and mitigate its unintended consequences.
Analysis of Tsunami Economic Loss in Tourism Area Using High-Resolution Tsunami Run-Up Model
Authors: Windupranata Wiwin , Nuraghnia Alqinthara , Al Ghifari Muhammad Wahyu , Pasaribu Sonia Kartini , Rakhmanisa Wiwin Indira , Vani Tiara , Ginting Kevin Agriva , Aventa Michael Bintang , Hayatiningsih Intan , Suwardhi Deni , Meilano Irwan , Mulia Iyan Eka , Lim Albert Kristiawan
Published: January 2025

A tsunami disaster can cause significant economic losses for a tourism area like Batukaras Village, which is located on the southern coast of Java Island. This paper tries to elaborate on the calculation of economic losses in tourism areas due to the damage to buildings, loss of land production and loss of income based on high-resolution geospatial data. The data are derived from UAV photogrammetry surveys and high-resolution tsunami run-up models. The tsunami worst-case scenario run-off model provides an inundation area of 43 ha with 185 buildings and 24.4 ha of productive land. The estimated losses from the tsunami disaster amounted to IDR 208.79 billion, consisting of 49.63 billion from building damage, 6.73 billion from productive land and 152.43 billion from the tourism sector. This result shows that the tsunami disaster will severely affect tourism areas because the tourism sector contributes 73% of the total economic losses. Reduction of the economic loss, in addition to spatial planning near the coastline to reduce the number of impacted buildings and productive land, can be achieved by accelerating the recovery period so that economic activities after the tsunami disaster can be carried out immediately, including in the tourism sector.
Reduction of Microfluidic Logical Pneumatic Mono Stable-Oscillators’ Reversible Outlet Flow
Authors: Rachid Khelfaoui , Abdelhak Bentaleb
Published: January 2025

Microsystems have been developed for a wide range of applications, including medical, military, and industrial maintenance, driven by advancements in actuating and measuring systems. Fluidic actuators, known for their compactness, low cost, and energy efficiency, are increasingly recognized for their potential in cutting-edge industrial and medical microsystems. This study explores the transition from traditional actuators to innovative mono-stable oscillators designed specifically for flow regulation. Mono-stable oscillators have long been acknowledged as effective tools for controlling fluidic logic. These devices provide a control solution without movable components, though they exhibit non-zero reverse output flow—a limitation consistently observed in prior research. Passive solutions, such as Tesla diodes or convergent-divergent conduits, have proven insufficient to address this issue. In this work, we propose a novel approach to eliminate reverse flow by introducing a moving object within the outlet oscillator. Through simulation, we demonstrate that this method effectively mitigates recirculation, offering a significant improvement over existing designs. This study provides a promising solution to enhance the performance of fluidic actuators in microfluidic systems.
Advances and Challenges in 3D Bioprinted Cancer Models: Opportunities for Personalized Medicine and Tissue Engineering
Authors: Liu Sai , Jin Pan
Published: January 2025

Cancer is the second leading cause of death worldwide after cardiovascular disease, claiming not only a staggering number of lives but also causing considerable health and economic devastation globally, particularly in less-developed countries. Additionally, therapeutic interventions are further impeded by patient-to-patient differences in responses to anti-cancer drugs. Therefore, personalized medicines approach is crucial for this specific patient group including use of molecular and genetic screens to find appropriate stratification of patients that respond (and those that will not) to treatment regimen. But the information on which risk stratification method can be used to hone in on those cancer types and patients that will be likely responders to a specific anti-cancer agent remains elusive for most cancers. Novel developments in 3D bioprinting technology have been widely applied to recreate relevant bioengineered tumor organotypic structures, capable of mimicking the human tissue and microenvironment or adequate drug response in high throughput screening settings. Experiences are autogenously printed in the form of 3D bioengineered tissue using a computer-aided design concept where multiple layers each include different cell types and compatible biomaterials to build up specific configurations. Patient-derived cancer and stromal cells together with genetic material, extracellular matrix proteins and growth factors are used to create bioprinted cancer models which provide a possible platform for the screening of new personalized therapies in advance. To encourage the growth of cells and biological material in those personalized tumor models/implants both natural as well synthetic biopolymers have been used. These models may help in a physiologically relevant cell–cell and cell–matrix interactions with 3D heterogeneity resembling real tumors.
Impact of Pharmacist Educational Intervention on Costs of Medication for Diabetic Patients in Various Tertiary Care Hospitals in Malaysia: A Randomized Controlled Trial
Authors: Iqbal Muhammad Zahid , Alqahtani Saad Saeed , Shahid Sara , Orayj Khalid M.
Published: January 2025

Background and Objective:
A lifestyle-associated disease, Diabetes Mellitus, mandates compliance with established policies by physicians and patients to achieve optimal glycemic control. Collaborative care from healthcare providers and patients is essential for effective management, which slows disease progression, improves quality of life, and reduces medication costs. This study assessed the effectiveness of pharmacist-led education initiatives on clinical outcomes and direct treatment costs for patients who have diabetes in two public hospitals in Malaysia.
Methods: Four hundred diabetes patients included in the study that were randomly allocated to two corresponding groups. Another group as the control group, consisting of two hundred patients, received standard treatment, whereas the patients in intervention group, including two hundred patients, received pharmacist-led care via Diabetic Medication Therapy Adherence Clinics (DMTAC) with conventional treatment. Pharmacists provided educational interventions emphasizing dietary adjustments, lifestyle modifications, the significance of physical activity, and appropriate medication storage. Among these, 143 control patients and 156 intervention patients completed the one-year study, which comprised two follow-up visits. Clinical outcomes and treatment expenses were evaluated and the analysis of data was performed utilizing version 24 SPSS. Descriptive statistics were presented as mean ± standard deviation, including normality assessed using the skewness, kurtosis and Kolmogorov-Smirnov test. Two-way ANOVA or Independent t-tests were applied for hypothesis testing when data showed normal distribution.
Results: After the research, group receiving intervention had a much higher decrease in HbA1c levels relative to the control group (3.59% versus 2.17%; p < 0.001). The intervention group had considerable decreases in systolic blood pressure (9.29 mmHg) and similarly in diastolic blood pressure (7.58 mmHg; with p < 0.005). Additionally, levels of cholestrol in the intervention group improved significantly (0.13 mmol/L; p < 0.001). Moreover, treatment expenses for the pharmacist-led intervention group shown a substantial reduction (p < 0.001). By the second follow-up, the additional cost per patient since baseline was RM 236.07 in the control group, compared to only RM 47.33 per patient in the intervention group with pharmacist involvement.
Conclusion: Pharmacist-led interventions led to a significant improvement in HbA1c levels. While medication expenses increased in both groups from the initial follow-up, the control group exhibited significantly greater increase levels than the intervention group.