bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Pengembangan Model Program Kepemudaan Inovatif dan Produktif
Authors: Suwandi Suwandi
Published: August 2022

Tujuan penelitian ini adalah untuk: (a) Mengidentifikasi jenis program kepemudaan yang dilakukan oleh Pemerintah, (b) Mengidentifikasi keterlibatan pemuda pada program kepemudaan, (c) Memahami persepsi pemuda tentang program-program kepemudaan, (d) Memahami keterkaitan program dengan harapan memperoleh pekerjaan, (e) Mengetahui bentuk bantuan program kepemudaan, (f) Memahami persepsi pemuda terhadap bimbingan usaha, (g) Megetahui manfaat dan prospek pekerjaan atas program kepemudaan, dan (h) Merumuskan model kebijakan pembinaan kepemudaan. Penelitian dilakukan selama lima bulan, sejak Juli hingga November 2005. Sampel diambil secara purposive terhadap program KUPP. Komposisi responden: pemuda 760 orang, birokrat 76 orang, kepala desa 76 orang, mitra kerja 57orang, siswa 76orang. Metode analisis data menggunakan kualitatif. Hasil penelitian menunjukkan bahwa: (a) Program kepemudaan yang diselenggarakan oleh Dinas Pendidikan antara lain: SP3 dan KUPP, (b) Keterlibatan pemuda meliputi: LK, KKP, KPS, LK Aktivitas dan Mutu Kepemudaan, Program Partisipasi dan Wawasan Kepemudaan, Program Pengembangan Aktivitas Kepemudaan/Program Partisipasi dan Wawasan Pemuda., (c) Persepsi pemuda terhadap program bahwa keberadaan program dirasakan sangat penting, karena dapat menyalurkan bakat dan memberikan penghasilan. serta memberikan penghasilan dan menambah wawasan, (d) Keberadaan program dirasakan sangat penting, karena dapat menyalurkan bakat dan memberikan penghasilan dan menambah wawasan. Program tersebut bermanfaat bagi calon pencari kerja khususnya bagi pemuda yang belum bekerja pelatihan, (e) Bentuk bantuan nerupa uang sebesar Rp 1.250.000,00 sampai dengan Rp 50.000.000,00 (f) Persepsi pemuda tentang bimbingan usaha sangat baik. Sebagian besar peserta program mendapatkan bimbingan dari mitra, (g) Manfaat dan prospek pekerjaan dirasakan belum mampu meningkatkan besarnya penghasilan pekerjaan, akan tetapi sebagian besar peserta optimis prospek usaha mereka bisa bertahan, dan (h) Model kebijakan pembinaan pemuda yang dapat diterapkan yaitu Program Sarjana Pencipta Kerja Mandiri (Prospek Mandiri) sebagai pengganti SP3 dan program KUPP yang diperbaharui terutama dalam mekanisme pelaksanaannya.
Angka Lempeng Total Bakteri dan pH pada Cairan Rumen Sapi Bali Jantan yang Dipotong di Rumah Pemotongan Hewan Pesanggaran
Authors: Mirahsanti Ni Putu Nicky , Suarjana I Gusti Ketut , Besung I Nengah Kerta
Published: August 2022

Tujuan penelitian ini adalah untuk mengetahui pH dan angka lempeng total bakteri (ALTB) pada rumen sapi bali dengan materi penelitian berupa cairan rumen sapi bali jantan sebanyak 17 sampel. Penelitian ini merupakan penelitian observasional analitik pendekatan Cross Sectional dengan pengamatan terhadap angka lempeng total bakteri (ALTB) dan pH di dalam rumen. Data yang diperoleh selanjutnya disajikan secara deskriptif. Kemudian, perbedaan ALTB pada pH tertentu dianalisis dengan Independent Sample T- test. Hasil penelitian menunjukkan bahwa kisaran pH rumen sapi bali adalah 6,8 sampai 7 dengan rerata 6,4 ± 0,1 dan kisaran ALTB yaitu 32 x 103 sampai 171 x 103 CFU/ml dengan rerata 74 x 103 ± 47 x 103 CFU/ml. Tidak ada perbedaan yang signifikan antara ALTB pada pH 6,8 dan ALTB pada pH 7.
Pengaruh Pemberian Ekstrak Kulit Pisang Kepok terhadap Histologi Ginjal, Kadar Ureum dan Kreatinin Tikus Putih setelah Melakukan Latihan Intensif
Authors: Astawibawa Putu Oky , Suarsana I Nyoman , Suartini I Gusti Ayu Agung
Published: August 2022

Aktivitas fisik berlebih memicu terbentuknya reactive oxygen species (ROS) yang dapat merusak ginjal dan organ lain. Penelitian ini bertujuan mengetahui pengaruh ekstrak kulit pisang kepok terhadap kadar ureum, kreatinin dan histologi ginjal tikus putih setelah pemberian latihan intensif. Penelitian ini menggunakan 27 ekor tikus putih jantan dengan berat badan 200-225g. Tikus dibagi menjadi tiga kelompok perlakuan yaitu (T0) kontrol, (T1) latihan intensif, (T2) latihan intensif dan diberi ekstrak kulit pisang kepok yang menggunakan dosis 1 cc/kg bb selama 28 hari. Sampel ureum di uji dengan metode Urea Col dan sampel kreatinin di uji dengan metode jaffe sedangkan sampel ginjal di periksa menggunakan preparat histologi dengan metode perwarnaan hematoksilin eosin (HE). Pada perlakuan T0 diperoleh kadar ureum dan kreatinin berturut-turut 89,456 ± 2,938 dan 0,867 ± 0,07 mg/dl; perlakuan T1 dengan kadar ureum dan kreatinin 101,144 ± 1.805 dan 0,944 ± 0,10 mg/dl, dan pada perlakuan T2 dengan kadar ureum dan kreatinin masing-masing 99,889 ± 4.075 dan 0,900 ± 0,00 mg/dl. Pengamatan histologi ginjal pada T1 ditemukan degenerasi dan nekrosis. Pada T2 terlihat penurunan degenerasi dan nekrosis disertai peningkatan regenerasi epitel sel tubulus proksimal dan distal. Kadar ureum pada kelompok perlakuan T1 dan T2 berbeda nyata terhadap T0, namun jika dilihat dari rata-rata standar deviasi menunjukan T2 mendekati kadar T0. Kadar kreatinin T2 tidak berbedanyata dengan T0 dan T1, sedangkan T0 berbedanyata dengan T1. Selain itu, ekstrak kulit pisang kepok mampu mencegah kerusakan jaringan ginjal namun belum berbeda nyata.
Pemetaan Perubahan Penggunaan Lahan Wilayah Pesisir Kecamatan Rungkut, Kota Surabaya, Tahun 2013 dan 2019
Authors: Pertami Diah , Nuarsa I Wayan , Nurweda Putra I Dewa Nyoman
Published: August 2022

The coastal area is a meeting space between land and sea that is easy to change temporally and spatially. The changes were triggered due to an increase in population and community activities such as industry, housing, ports, cultivation, transportation, farms, agriculture, tourism, and so on centered in the coastal area and become the center of Indonesia's economy. Remote sensing technology is one of the right ways for monitoring activities in the near term. This research aims to map the change of coastal land use in Rungkut district, Surabaya, in 2013 and 2019 using high-resolution satellite imagery of SPOT imagery. The method of classification of coastal land use two types of supervised classification, namely Minimum Distance and Maximum Likelihood. Land use class obtained in this study as many as six classes, namely mangrove, settlement, pond, green open space, the body of water, and industry. The results showed that using two different algorithms gave a difference in classification results. The largest land-use change from classification with Minimum Distance method is in mangrove and body of water with +231,80 and –230,89 ha, while the classification result with the method of Maximum Likelihood the change of the largest land use is in mangrove class and ponds respectively +202,41 and –210,89 ha. Accuracy test using error matrix obtained by 85,50% with kappa coefficient 0,78 on the classification result of coastal land use using Minimum Distance algorithm and for Maximum Likelihood algorithm obtained accuracy of 89% with Kappa coefficient is 0,84. It is demonstrated that by using the algorithm, Maximum Likelihood accuracy on the land use map is very good.
Estimasi Stok Karbon Di Atas Permukaan Menggunakan Citra Sentinel-1A di Hutan Mangrove Karang Sewu, Bali
Authors: Nuraini Nikmah Fitria , Karang I Wayan Gede Astawa , Putra I Nyoman Giri
Published: August 2022

Karang Sewu mangrove is one of the forests in the tropics that can store a higher amount of carbon compared to other forest. The researh of carbon storage in the Karang Sewu mangrove forest is required to support government policies in mitigating blue carbon. Research about above ground and below ground carbons in the Karang Sewu mangroves has not provided spatial information, and one of the techniques that can be used is remote sensing with Synthetic Aperture Radar (SAR). This research used SAR Sentinel-1A C-Band sensor imagery to estimate above-ground carbon in mangroves because it can penetrate the canopy to branch vegetation so that the backscatter value is not disturbed by water on the surface. The purpose of this study was to determine the above-ground carbon value in the mangrove forest Karang Sewu, Bali,  using Sentinel-1A imagery. Estimation of above-ground carbon in SAR images using the sigma nought Vertikal Horizontal polarization method based on carbon estimation models from field data and image data. The best carbon estimator model is a polynomial model with the equation y = 0.1055x2 + 4.1507x + 43,691, R2 = 0.3347. The Root Mean Square Error (RMSE) error rate is 0,7. Based on the RMSE value, it can be concluded that the difference between the field carbon and the image carbon results is relatively small The estimation result of the total above-ground carbon value using Sentinel-1A imagery is 59.85 tons/ha.
Quo Vadis Regulation on Underwater Cultural Heritage in Indonesia: Balancing Conservation and Economic Interest
Authors: Yuniza Mailinda Eka , Merdekawati Agustina , Talitha Putri Gilda , Abraham Guntur Jeremy
Published: August 2022

The management of underwater cultural heritage in Indonesia is still experiencing many obstacles, one of which is the imbalance between conservation and economic interest in managing underwater cultural heritage. The results indicate that these problems stem from the legal gap that exists in the Indonesian legal system. Existing Laws and Regulations have not been adequate to respond to the needs for conservation and proper economic utilization of underwater cultural heritage. The non-existent provision in regards to in situ and ex situ conservation, as well as the appraisal and selling methods, has led to further legal uncertainty. By using normative legal research methods, this research paper aims to analyze the urgency of managing valuable cargo objects from sunken ships classified as underwater cultural heritage objects and formulate a new concept of underwater cultural heritage management which contain seven steps that will balance both conservation and economic.
STUDIJA TRANSFROMACIJE ATRIJUMA MUZEJA VOJVODINE U NOVOM SADU
Authors: Kovačević Milica , Reba Darko
Published: August 2022

Tema istraživanja kao i sam zadatak master rada, zasniva se na naučno istraživačkom radu na primeru transformacije atrijuma Muzeja Vojvodine u Novom Sadu. Rad se fokusira na temu urbane sredine i atrijuma kao neodvojivog elementa iste, na koji način su grad i atrijumski prostori povezani, na koji način se takvi prostori formiraju, te kakav je uticaj na korisnike gradske sredine, neke su od ključnih tema master rada. U radu je približena retrospektiva nastanka atrijuma od njegovog nastanka još u doba antičke Grčke, pa sve do današnjih dana. U radu se osvrće na projektantski zadatak transformacije atrijuma Muzeja Vojvodine u Novom Sadu, sa primerom tri ideje kako bi se prostor mogao unaprediti, kako bi se ostvarila kvalitetnija veza između prostora atrijuma i njegovih korisnika.
The INOVATIVNOST OSNOVNA POKRETAČKA SNAGA PREDUZEĆA
Authors: Mitrović Jelena
Published: August 2022

Inovacije su jedna od osnovnih snaga u skupu pokretačkih snaga u razvoju procesa privređivanja i osnova su rasta nove vrednosti, često i ukupne dodate vrednosti pa prema tome i osnova trajanja preduzeća na tržištu. U radu je prikazana uloga i značaj inovativnih aktivnosti u menadžmentu poslovnih sistem, kao i uloga ljudskih resursa i tehnologija u stvaranju inovacija preduzeća na tržištu.
УНАПРЕЂЕЊЕ ПЕРФОРМАНСИ ПРОЈЕКAТА ИЗГРАДЊЕ СТАНИЦА ЗА СНАБДЕВАЊЕ КОМПРИМОВАНИМ ПРИРОДНИМ ГАСОМ (CNG) У СРБИЈИ
Authors: Аврамовић Андрија , Морача Слободан
Published: August 2022

Пројекти изградње инфраструк­туре за дистрибуцију и снабдевање компримованим природним гасом (CNG) друмског транспорта пред­стављају веома захтевну категорију капиталних про­јеката, нарочито у Србији. Њихове перформансе и остварени резултати зависе од великог броја фак­тора, како екстерних тако и интерних. У овом раду се детаљном анализом доступних информација о реа­лизованим пројектима и на основу стручне литера­туре предлажу начини за унапређење кључних пер­форманси CNG пројеката из различитих домена (про­јектни рокови, квалитет, буџет, ефикасност). При­мена предложених мера може резултирати даљем расту ове групе пројеката на домаћем тржишту.
ARHITEKTURA SISTEMA POSLOVNE INTELIGENCIJE
Authors: Popov Bojana
Published: August 2022

Poslovna inteligencija je naziv za proces prikupljanja, obrade i čuvanja podataka koji je podržan računarskim tehnologijama. Poboljšava proces donošenja odluka pružajući menadžmentu relevantne informacije o poslovanju. U radu je prikazana arhitektura sistema poslovne inteligencije i koristi nakon implemen­tacije.
OPTIMIZACIJA PROCESA INVESTIRANJA I KREIRANJE EFIKASNOG PORTFOLIJA PREDUZEĆA
Authors: Gavrilović Tijana
Published: August 2022

U radu je prikazana analiza upravljanja portfolijom, kao i uloga i značaj tehničke analize u cilju optimizacije procesa investiranja. Objašnjen je značaj aktivne i pasivne strategije upravljanja portfolijom kroz analizu portfolija akcija Komercijalne Banke a.d. i Alta Banke a.d.
САВРЕМЕНИ АСПЕКТИ ИЗРАДЕ ДИГИТАЛНОГ КАТАСТАРСКОГ ПЛАНА - СТУДИЈА СЛУЧАЈА: КАТАСТАРСКА ОПШТИНА ДАШНИЦА
Authors: Babić Sanja , Marinković Goran
Published: August 2022

Предмет истраживања овог мастер рада јесте превођење аналогних катастарских планова у векторски облик. Описан је детаљан поступак настанка дигиталног плана катастарске општине Дашница, општина Александровац. Урађена је анализа самог дигиталног плана, односно, анализа насталих грешака и начин њиховог отклањања. Циљ је да се увиди начин на који је извршена дигитализација као и значај израде дигиталног катастарског плана.
REALIZACIJA GEOSENZORSKE MREŽE ZA PERMANENTNI MONITORING KARAKTERISTIČNIH PARAMETARA LABORATORIJSKOG MODELA MOSTOVSKE KONSTRUKCIJE
Authors: Tunguz Rada
Published: August 2022

U okviru master rada izvršena je analiza tipova mostovskih konstrukcija sa posebnim osvrtom na vitalne parametre koji bi bili praćeni geosenzorskom mrežom u realnom vremenu. Nakon definisanja potrebnog skupa parametara, izabrani su senzori koji čine geosenzor­sku mrežu i predložena opšta hardverska konfiguracija geosenzorske mreže. Podešene su korisničke aplikacije za monitoring u realnom vremenu. Na pripremljenom labora­torijskom modelu mostovske konstrukcije izvršena su mere­nja statičkih i dinamičkih opterećenja sa ocjenom tačnosti. Izvršena je analiza rezultata i definisane finalne preporuke.
Management of Post-Prandial Blood Glucose Level Using Some Common Nigerian Thickeners
Authors:   University Of Port Harcourt, SC Onuoha
Published: August 2022

This study investigated the effect of the consumption of soups made from some Nigerian soup thickeners such as Brachystegia eurycoma (achi)
Concentration Effect on Foaming and Stability of Isolates from Two Varieties (DAS & BS) of Nigerian Cultivated Solojo Cowpea (Vigna Unguiculata L. Walp)
Authors:   Federal Institute Of Industrial Research, Chibudike Henry O
Published: August 2022

Concentration Effect on foaming capacity and stability of the various samples were investigated
Strategi Peningkatan Kapasitas Peternak Domba melalui Kampus Desa Tematik di Desa Neglasari, Bogor, Jawa Barat
Authors: Muljono Pudji , Indriana Hana , Novindra  , Bachtiar Yannefri , Mintarti
Published: August 2022

The process of disseminating innovation so that it can be quickly responded by the user community needs to be designed in such a way that it can produce relatively permanent changes in behavior. This study aims to analyze how the strategy of increasing the capacity of sheep farmers through the thematic village campus program in Neglasari Village, Bogor. The research was designed as action research at the study site, accompanied by the use of survey methods with a quantitative approach and supported by qualitative data. The selection of study sites was carried out purposively. The process of collecting data was carried out on sheep breeders, members of women's farmer groups, informants and related stakeholders. The Village Campus Program has accelerated the technology education process produced by the campus to the community, becoming a vehicle for lecturer service, linkage with faculty programs or study programs. In order for this program to be sustainable, it is necessary to involve various parties such as alumni, local leadership, based on user needs, as well as conducting regular meetings on a programmed basis.
Carnaval Negros y Blancos: Cimarrones del Valle del Patía y el Pacífico Nariñense en el Carnaval de Negros y Blancos de San Juan de Pasto
Authors: Mojica Madera Javier
Published: August 2022

Este proyecto de indagación se realiza en las costas del Pacífico colombiano, en una de las regiones más bellas y recónditas a lo largo de su litoral costero y tierras bajas del Cauca: el valle del Patía. En este valle interandino se salvaguarda una tradición cultural de más de 200 años: los Carnavales de Negros y Blancos de San Juan de Pasto, declarado por la Unesco como Patrimonio Oral e Immaterial de la Humanidad en el 2009. La investigación procura exaltar la presencia de las comunidades negras del valle del Patía al sur del país, su cultura y su folclor como proceso identitario de transformación de la población afrodescendiente en Colombia evidenciando el reconocimiento, presencia e incursión de estos grupos minoritarios en un espacio transgresor que promueve y representa la memoria viva del Pacífico colombiano, donde se reconstruyen nuevas prácticas discursivas diversas y análogas. El Carnaval, manifestación ancestral que promueve la tradición y el legado familiar de negros e indígenas de los departamentos del Cauca y Nariño, enaltece la sabiduría de los pueblos y eleva su reconocimiento como baluarte en esta celebración. Es punto de partida de saberes milenarios incas, africanos y españoles en territorios del sur de Colombia; enmarca lo ritual y ancestral en los andes nariñenses, rescatando los testimonios de prácticas orales heredadas de generación en generación, y hace manifiesto el espíritu alegre de los pueblos del Patía y del Pacífico de Nariño.
Huellas. Lesiones Elementales de la Piel
Authors: Varela Hernández César Iván
Published: August 2022

Huellas: Lesiones elementales de la piel es producto del diario vivir de la profesión médica dermatológica y de su enseñanza durante muchos años. Es un texto de estudio dirigido a los estudiantes de medicina, a los médicos residentes de dermatología y de las especialidades afines, y a los médicos generales y especialistas con cuyas áreas comparte dolencias la especialidad. Los seis capítulos recorren la historia clínica, el examen físico general, el específico de las lesiones elementales de la piel, la clasificación de las lesiones de mayor uso en la actualidad y las designaciones históricamente utilizadas, los diversos patrones de presentación y características intrínsecas, la distribución preferencial por zonas del cuerpo de algunas de las enfermedades dermatológicas más frecuentes, y finaliza con ejemplos clínicos del arte de describir las lesiones. Tiene como propósito fundamental facilitar el conocimiento o el recuerdo, y la identificación y descripción de las lesiones elementales de la piel de manera práctica, para llegar a una aproximación diagnóstica más rápida y certera, en beneficio del enfermo. Para ello, además del texto, muestra 576 fotografías que se presentan con todo respeto y cuidado, así como tablas y esquemas que resumen información para su consulta expedita. El libro es un homenaje a la Universidad del Valle en su septuagésimo quinto aniversario de creación, a su Facultad de Medicina en el septuagésimo y a la Sección de Dermatología del Departamento de Medicina Interna en su quincuagésimo aniversario. El autor destaca su gratitud a familiares, colegas y estudiantes.
Rastreio do Hiperaldosteronismo Primário: Reprodutibilidade e Abrangência
Authors: Teodoro Matheus Serapião , Carvalho Alessandra Juliana de , Vimieiro Gabriel Procópio , Oliveira Lettícia Araújo de , Ferreira Ana Júlia Mansur Soares , Santos Mariana Silva , Trotta Rafaella Dias , Souza Daniel Zanini Bernardino de , Ribeiro Fernanda D'Avila , Bastos Marcelo Ribeiro
Published: August 2022

Objetivo: Abordar os aspectos sobre o rastreio do Hiperaldosteronismo Primário (HAP) e discutir sobre a necessidade de abranger toda a população de hipertensos. Revisão Bibliográfica: O HAP possui uma elevada prevalência e dois principais subtipos. Sua relação com desfechos cardiovasculares desfavoráveis é grande, comparado aos hipertensos primários. O rastreio é uma estratégia importante pois o tratamento direcionado é capaz de reduzir significativamente os níveis pressóricos e o risco cardiovascular, por vezes até curar a hipertensão no tratamento cirúrgico, e melhorar o perfil bioquímico. Dessa forma, julgando os fatores mencionados e o seu custo-benefício, é importante que a realização do rastreio em toda a população de hipertensos seja considerada na prática da clínica médica. Considerações Finais: Embora a indicação para rastreio do HAP tenha grupos certos de pacientes, dado o risco aumentado de cada um, este trabalho mostra que o rastreio pode se estender à todas as hipertensões recém-diagnosticadas, dada a alta prevalência, bom custo-benefício e potencial de morbimortalidade do HAP.
Impact of COVID-19 pandemic on using dental radiography
Authors: Yıldızer Keris Elif , Çelik Berrin , Arslan Zeynep Betül
Published: August 2022

Objectives:

This study aimed to analyze the impact of the COVID-19 pandemic on using dental radiography.

Materials and Methods:

This retrospective study included adult patients who applied at 3-time intervals reflecting changes in the course of the COVID-19 pandemic in 2020 (T1-T2-T3). Patients’ demographics, the number of radiographic and clinical procedures provided, and radiographic findings were noted during T1-T2-T3.

Results:

The frequency of using dental radiography was the lowest at the beginning of the pandemic and significantly increased over time. Using radiography increased when the number of COVID-19 cases increased. The course of the COVID-19 disease did not affect using radiography by dentists. The use of dental radiography in elderly patients was found to be less than in younger patients. Invasive treatments applied to the patients who had radiographs were significantly higher than those who had not at T2 and T3.

Conclusion:

This study demonstrated the changes in dental radiographic procedures during the pandemic. It was ordered to avoid intraoral radiography as much as possible due to aerosol production during the COVID-19 pandemic. To make better use of dental radiography, manufacturers should improve extraoral radiography with better image quality with lower radiation doses.
Three-center-four-electron halogen bond enables non-metallic complex catalysis for Mukaiyama–Mannich-type reaction
Authors: OISHI Shunya , FUJINAMI Takeshi , MASUI Yu , SUZUKI Toshiyasu , KATO Masayuki , OHTSUKA Naoya , MOMIYAMA Norie
Published: August 2022

The three-center-four-electron halogen bond (3c4e X-bond) presents a fundamental design concept for catalysis. By integrating halogen(I) (X+: I+ or Br+), bis-pyridyl ligand NN, and non- nucleophilic counter anion Y, we developed non-metallic complex catalysts, [N···X···N]Ys, that exhibited outstanding activity and facilitated the Mukaiyama–Mannich-type reaction of N- heteroaromatics with parts-per-million-level catalyst loading. The high activity of [N···X···N]SbF6 was clearly demonstrated. NMR titration experiments, CSI-MS, computations, and UV-vis spectroscopic studies suggest that the robust catalytic activity of [N···X···N]Y can be attributed to the unique feature of the 3c4e X-bond for binding chloride: i) the covalent nature transforms [N···X···N]+ complexation to sp2CH as a hydrogen bonding donor site, and ii) the noncovalent property allows for the dissociation of [N···X···N]+ for the formation of [Cl···X···Cl]–. This study introduces the application of 3c4e X-bonds for catalysis via halogen(I) complexes.
An Automated Variable E-Field DFT Application (A.V.E.D.A.) for Evaluation of Optimally Oriented Electric Fields on Chemical Reactivity
Authors: Hanaway Dalton , Kennedy Rose
Published: August 2022

Recent theoretical and experimental work at molecular junctions has provided a strong conceptualization for the effects of oriented electric fields (OEFs) on organic reactions. Depending upon the axis of application, OEFs can increase (or decrease) reaction rate or distinguish between enantiomeric pathways. Despite the conceptual elegance of OEFs, which may be applied externally or induced locally, as tools for catalyzing organic reactions, implementation in synthetically relevant systems has been hampered by inefficiencies in evaluating reaction sensitivity to field effects. Herein we describe the development of the Automated Variable Electric-Field DFT Application (A.V.E.D.A.) for streamlined evaluation of a reaction’s susceptibility to OEFs. This open-source software was designed to be accessible for novice users of computational or programming tools. Following initiation by a single command (and with no subsequent intervention) the Linux workflow manages a series of density functional theory (DFT) calculations and mathematical manipulations to optimize ground-state and transition-state geometries in oriented, electric fields of increasing magnitude. The resulting field-perturbed geometries, molecular and reaction dipole moments, and net effective activation energies are compiled for user interpretation. Ten representative pericyclic reactions that showcase the development and evaluation of A.V.E.D.A. are described.
β-NiOOH is An Active Electrocatalyst for the Ammonia Oxidation Reaction Predicted by Density Functional Theory
Authors: Choueiri Rachelle M. , Chen Leanne D.
Published: August 2022

The electrocatalyzed ammonia oxidation reaction (AOR) is an ambient temperature and pressure process with potential applications for sustainable energy generation and waste ammonia treatment. In this work, we study the mechanism of ammonia oxidation towards N2, NO2– , and NO3– on the (0001) β-NiOOH surface and compare the computed free energy of reaction intermediates to results previously obtained on (0001) β-Ni(OH)2. NiOOH surfaces with a hydroxide vacancy favoured NH2–NH2 coupling and reduced the theoretical onset potential for N2, NO2–, and NO3– relative to the β-Ni(OH)2 surface. The surface with an oxygen vacancy favoured NH–NH coupling, and had lower onset potentials for N2 and NO2– formation relative to the β-Ni(OH)2 surface, while NO3– formation was slightly hindered due to its increased stabilization of the precursor adsorbate, *NO2. In general, the NiOOH surface had lower computed onset potentials compared to the Ni(OH)2 surface due to the destabilization of certain adsorbates which form thermodynamic sinks in the AOR pathway, leading to differences in the potential-determining step for the formation of N2 and NO2–. This work sheds light on the ammonia electrooxidation mechanism on β-NiOOH and predicts the material to be a much more active electrocatalyst compared to β-Ni(OH)2.
How Nature makes O2: an electronic level mechanism for water oxidation in photosynthesis.
Authors: O'Malley Patrick , Rummel Felix
Published: August 2022

In this report we combine broken symmetry density functional calculations and electron paramagnetic resonance analysis to obtain the electronic structure of the penultimate S3 state of Nature’s water oxidising complex and determine the electronic pathway of O-O bond formation. Analysis of the electronic structure changes along the reaction path shows that two spin crossovers, facilitated by the geometry and magnetism of the water oxidising complex are used to provide a unique low energy pathway. The pathway is facilitated via formation and stabilisation of the [O2]3- ion. This ion is formed between ligated deprotonated substrate waters, O5 and O6, and is stabilised by antiferromagnetic interaction with the Mn ions of the complex. Combining computational, crystallographic and spectroscopic data we show that an equilibrium exists between an O5 oxo and O6 hydroxo form with an S=3 spin state and a deprotonated O6 form containing a two-centre one electron bond in [O5O6]3- which we identify as the form detected using crystallography. This form corresponds to an S=6 spin state which we demonstrate gives rise to a low intensity EPR spectrum compared with the accompanying S=3 state, making its detection via EPR difficult and overshadowed by the S=3 form. Simulations using 70% of the S=6 component give rise to a superior fit to the experimental W- band EPR spectral envelope compared with an S=3 only form. Analysis of the most recent X-ray Electron Spectroscopy (XES) first moment changes for solution and time resolved crystal changes are also shown to support the model. The computational, crystallographic and spectroscopic data are shown to coalesce to the same picture of a predominant S=6 species containing the first one-electron oxidation product of two water molecules i.e. [O5O6]3-. Progression of this form to the two-electron oxidised peroxo and three-electron oxidised superoxo forms, leading eventually to the evolution of triplet O2, is proposed to be the pathway Nature adopts to oxidise water. The study reveals the key electronic, magnetic and structural design features of Nature’s catalyst which facilitates water oxidation to O2 under ambient conditions.
Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead
Authors: Meden Anže , Knez Damijan , Brazzolotto Xavier , Modeste Fabrice , Perdih Andrej , Pišlar Anja , Zorman Maša , Denic Milica , Pajk Stane , Nachon Florian , Gobec Stanislav
Published: August 2022

Beside reversible butyrylcholinesterse inhibitors (BChEIs), a plethora of covalent ones, typically pseudo-irreversible carbamates, have been reported in literature. For the latter, however, in most cases the proper confirmation of their covalent mode of action is lacking. Additionally, the available reports on the structure-activity relationships of the O-arylcarbamate warhead are incomplete. Therefore, a follow-up on a series of pseudo-irreversible covalent carbamate human butyrylcholinesterase inhibitors (hBChEIs) and the structure-activity relationships of the N-dialkyl O-arylcarbamate warhead is presented. The covalent mechanism of binding was tested by IC50 time-dependency profiles, and sequentially and increasingly confirmed by kinetic analysis, whole protein LC-MS, and crystallographic evidence. The computational studies provided valuable insights into the steric constraints and identified problematic, bulky carbamate warheads that could not reach and carbamoylate the catalytic Ser198. QM calculations lent further evidence that the steric effects seemed to be a key factor in determining the covalent binding behaviour of these carbamate ChEIs and their duration of action. Furthermore, the introduction of a clickable terminal alkyne moiety into one of the carbamate N-substituents and in situ derivatization with an azide-containing fluorophore enabled fluorescent labelling of plasma hBChE. This proof-of-concept study highlighted the potential of this novel approach and these compounds to be further developed as clickable molecular probes for investigating tissue localization and activity of ChEs.
Hierarchical porosity of hybrid carbon nanomaterials based on a covalent triazine framework for high-performance capacitive energy storage
Authors: Hryniewicka Agnieszka , Breczko Joanna , Siemiaszko Gabriela , Brzezinski Krzysztof , Ilnicka Anna , Terzyk Artur , Plonska-Brzezinska Marta
Published: August 2022

Covalent triazine frameworks (CTFs) constitute an emerging class of high-performance materials due to their porosity and the possibility of structural control at the molecular or atomic level. However, the use of CTFs as electrodes in supercapacitors is hampered by their low electrical conductivity and a strong stacking effect between adjacent CTFs. Herein, two series of hybrid carbon nano-onion-based CTFs were designed and successfully synthesized using an ionothermal process at 700 °C. The CTF could undergo framework growth in two or four directions, which was related to the presence of a defined number of nitrile groups in the substrate. CTF counterparts without carbon nano-onions were also synthesized as reference materials. The hybrid materials exhibited excellent specific capacitances, with the highest value exceeding 495 F g-1. It should be emphasized that the specific capacitance value for hybrids was 1.5-2 times higher than that for the reference CTFs. In this study, we examined the factors responsible for such a large increase in electrochemical efficiency. This strategy has significantly expanded the scope and application of CTFs as high-performance electrode materials for electrochemical energy storage systems.
Large Changes in Hydricity as a Function of Charge and Not Metal in (PNP)M-H (De)hydrogenation Catalysts That Undergo Metal-Ligand Cooperativity
Authors: Schlenker Kevin , Casselman Lillee , VanderLinden Ryan , Saouma Caroline
Published: August 2022

Pincer-ligated catalysts that can undergo metal-ligand cooperativity (MLC), whereby H2 is heterolytically cleaved (with proton transfer to the ligand and hydride transfer to the metal), have emerged as potent catalysts for the hydrogenation of CO2 and organic carbonyls. Despite the plethora of systems developed that differ in metal/ligand identity, no studies establish how variation of the metal impacts the pertinent thermochemical properties of the catalyst, namely the equilibrium with H2, the hydricity of the resulting hydride, and the acidity of the ligand. These parameters can impact the kinetics, scope, and mechanism of catalysis and hence should be established. Herein, we describe how changing the metal (Co, Fe, Mn, Ru) and charge (neutral vs. anionic) impacts these parameters in a series of PNP-ligated catalysts (PNP = 2,6-bis[(di-tert-butylphosphino)methyl]pyridine). A linear correlation between hydricity and ligand pKa (when bound to the metal) is found, indicating that the two parameters are not independent of one another. This trend holds across four metals, two charges, and two different types of ligand (amine/amide and aromatization/dearomatization). Moreover, the effect of ligand deprotonation on the hydricity of (PNP)(CO)(H)Fe-H and (PNP)(CO)(H)Ru-H is assessed. It is determined that deprotonation to give anionic hydride species enhances the hydricity by ~ 16.5 kcal·mol-1 across three metals. Taken together, this work suggests that the metal identity has little effect on the thermodynamic parameters for PNP-ligated systems that undergo MLC via (de)aromatization, whilst the effect of charge is significant; moreover, ion-pairing allows for further tuning of the hydricity values. The ramifications of these findings for catalysis are discussed.
Features of rhythmic activity of pianists' hands when performing motor tests at the fastest possible pace
Authors: Курова Мария Сергеевна , Белякова Евгения Александровна
Published: August 2022

Проведена графическая регистрация произвольных ритмических движений пальцев и кистей рук у девочек, обучающихся игре на клавишных инструментах, с последующим анализом их количественных характеристик. Выявлены более высокие скоростные качества обеих рук пианисток при выполнении программированных движений по сравнению с испытуемыми контрольной группы. Установленная низкая внутри и межгрупповая дисперсность длительности двигательных циклов при воспроизведении пианистами максимального темпа пальцами, а также выраженная правосторонняя моторная асимметрия рук, рассматривается как результат влияния музыкальных нагрузок. Предлагаемые методики определения лабильности и согласованности ритмических движений дистальных звеньев кинематической цепи рук могут быть использованы для оценки профессиональной подготовленности пианистов.

Graphic registration of arbitrary rhythmic movements of fingers and hands in girls learning to play keyboard instruments was carried out, followed by analysis of their quantitative characteristics. Higher speed qualities of both hands of pianists at performance of the programmed movements in comparison with subjects of control group are revealed. The established low internal and intergroup dispersion of duration of motor cycles at reproduction by pianists of the maximum tempo with fingers, and also the expressed right-hand motor asymmetry of hands, is considered as result of influence of musical loadings. The proposed methods for determining the lability and consistency of rhythmic movements of the distal members of the kinematic chain of the hands can be used to assess the professional training of pianists
Comparative characteristics of the structure of the respiratory cycle at additional expiratory resistance and speech respiration
Authors: Морозов Глеб Игоревич , Миняева Арина Владимировна , Петушков Михаил Николаевич
Published: August 2022

У 8 практически здоровых молодых женщин исследовано поведение торакального и абдоминального компонентов системы дыхания при произнесении ритмичного текста и при дыхании с дополнительным сопротивлением на выдохе. Выявлено, что речевое дыхание и дыхание с экспираторным сопротивление имеют сходный паттерн, что позволяет рассматривать речевое дыхание как дыхание с экспираторным сопротивлением.

In 8 practically healthy young women, the behavior of the thoracic and abdominal components of the respiratory system was studied when pronouncing a rhythmic text and when breathing with additional resistance on exhalation. It is revealed that speech breathing and breathing with expiratory resistance have a similar pattern, which allows treating speech breathing as breathing with expiratory resistance.
Features of aerobic support in resting athletes with different constitutional characteristics
Authors: Арепина Наталья Юрьевна , Голоулина Елена Александровна , Лисицына Юлия Николаевна , Резаева Анна Владимировна
Published: August 2022

В статье рассматриваются особенности аэробного обеспечения у спортсменов разных ростовых групп и с разной степенью выраженности динамических компонентов массы тела в условиях покоя. Перекрестный анализ данных по исследуемым группам спортсменов позволил установить, что увеличение значений показателей, характеризующих габитус спортсменов, повышает энергетические запросы организма. Предполагается, что установленная взаимосвязь отражает компенсационный механизм энергообеспечения, обеспечивающего соответствующий уровень метаболизма и оптимизацию аэробного обеспечения в условиях мышечного покоя

The article considers the features of aerobic support at rest in athletes of different growth groups and with different degrees of expression of the dynamic components of body weight. Cross-analysis of data on the studied groups of athletes revealed that increasing the values of indicators that characterize the habit of athletes, increases the body's energy needs. It is assumed that the established relationship reflects the compensatory mechanism of energy supply, ensuring the appropriate level of metabolism and optimization of aerobic supply in conditions of muscles at rest.
Omparison of physical and aerobic performance in biathlonists and racing skiers
Authors: Солонин Юрий Григорьевич , Гранов Игорь Олегович , Логинова Татьяна Петровна , Марков Александр Леонидович
Published: August 2022

При максимальной нагрузке повышенная степень тренированности обнаруживается у лыжников-гонщиков по мощности и длительности нагрузки на велоэргометре, по пульсовой и сердечной стоимости единицы работы, по валовому и удельному значению МПК. Организм лыжников-гонщиков при максимальной нагрузке по значению КПД работает более эффективно, чем организм биатлонистов. Более высокая тренированность у лыжников-гонщиков РК проявляется в экономизации функций кардиореспираторной системы как в покое, так и при максимальных велоэргометрических нагрузках, а также по показателям удельной физиологической стоимости единицы работы. Повышенные функциональные возможности (или резервы) лыжникигонщики показывают по таким параметрам как ЧСС, ЧД, МОД, ПК и ЭТ. Заключение: у биатлонистов аэробная производительность организма ниже, чем у лыжников-гонщиков, в связи с меньшим объемом тренировочных нагрузок по бегу на лыжах. Спортсменысеверяне по аэробной работоспособности уступают спортсменам из других регионов страны и мира. При медико-биологических и физиологических исследованиях группы биатлонистов и лыжниковгонщиков следует рассматривать отдельно.

At maximum load, an increased degree of fitness is found among cross-country skiers in terms of power and duration of exercise on a bicycle ergometer, in terms of pulse and heart cost per unit of work, and in gross and specific VO2 max. The body of skiers-racers at maximum load in terms of efficiency value works more efficiently than the body of biathletes. A higher level of fitness among skiers-racers of the Republic of Kazakhstan is manifested in the economization of the functions of the cardiorespiratory system both at rest and at maximum cycle ergometric loads, as well as in terms of the specific physiological cost of a unit of work. Increased functionality (or reserves) skiers-racers show in such parameters as heart rate, HR, MO, PC and ET. Conclusion: in biathletes, the aerobic performance of the body is lower than in skiers-racers, due to the lower volume of training loads for cross-country skiing. Athletes from the north are inferior in aerobic performance to athletes from other regions of the country and the world. In biomedical and physiological studies, the groups of biathletes and cross-country skiers should be considered separately.
INFRASTRUKTUR TEKNOLOGI INFORMASI UNTUK MENDORONG KNOWLEDGE SHARING INTENTION: STUDI KASUS SISTEM RUMAH SAKIT
Authors: Widyarini Florencia Judith , Kornarius Yoke Pribadi , Caroline Angela , Gunawan Agus
Published: August 2022

Pandemi COVID-19 memaksa rumah sakit untuk berbagi pengetahuan dengan lebih sering, sehingga staf medis memiliki kemampuan yang memadai untuk menangani pasien dengan lebih baik. Salah satu alat yang dapat mendukung aktivitas berbagi pengetahuan adalah ketersediaan infrastruktur teknologi informasi yang memadai. Penelitian ini bertujuan untuk menjabarkan bagaimana pengaruh infrastruktur teknologi informasi rumah sakit terhadap niat berbagi pengetahuan di RS St. X. Penelitian ini menggunakan metode kuantitatif dengan teknik purposive sampling. Data yang diperoleh sebanyak 45 responden pegawai di biro keuangan dan biro pengadaan dan logistik di RS St. X. Hasil Penelitian menunjukan dimensi prosedur memiliki skor tertinggi dan dimensi jaringan memiliki skor terendah dalam variabel infrastruktur teknologi informasi. Sedangkan untuk variabel niat berbagi pengetahuan, dimensi kedekatan memiliki skor tertinggi dan jenis knowledge memiliki skor terendah. Hasil penelitian yang menunjukkan tidak berpengaruhnya infrastruktur teknologi informasi terhadap niat berbagi pengetahuan, membuat rumah sakit harus dapat membenahi infrastruktur teknologi informasi sebelum melanjutkan pengembangannya. Salah satunya dengan memberikan penghargaan untuk pegawai yang secara aktif dan teratur menggunakan fasilitas infrastruktur teknologi informasi terutama sebagai media untuk menyebarkan pengetahuan.
Basal Cell Carcinoma
Authors: Mustofa Ali , Nur Sholikah Tri Rosalia , Niari Tapi Singgar , Rahmawati Yuli Wahyu
Published: August 2022

Background: Basal Cell Carcinoma (BCC) is a malignant neoplasm of non-keratinized cells in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasizes. BCC more commonly occurs in the elderly. Exposure to ultraviolet (UV) rays is the main risk factor for BCC, so predilection is areas of the body that are exposed to UV rays, especially the face, ears, and neck.Case presentation: The following is a case report of a 65-year-old female patient who works as a farmer. The patient was diagnosed with basal cell carcinoma (BCC) with complaints of black nodules on the face, itching, and bleeding easily. With Dermatological status obtained. The lesion ad regio Fascialis Dextra shows a solitary hyperpigmented nodule, nummular in size, well-circumscribed, and unilateral.Conclusion:Basal cell carcinoma is a malignant skin tumor originating from non-keratinizing cells in the basal layer of the epidermis.
Meningkatkan Kemampuan Mengenal Keaksaraan Awal Melalui Media Stiker Dots
Authors: Listiani Listiani , Musi Muhammad Akil , Alriani Ineke
Published: August 2022

This study aims to improve the language skills of children in Group A in recognizing vowels through dots sticker media at. This research uses a Classroom Research Approach (CAR). The subjects of this study were children in group A at Dharma Wanita Kindergarten, Senden, Kec. Kayen Kidul Kab. Kediri, East Java, totaling 6 children. The object of this research is to increase the ability to recognize vowels through dots sticker media. Methods of data collection is done through observation and documentation. The data analysis technique was carried out descriptively quantitatively. The results showed a significant change, namely an increase in the ability to recognize vowels. This is evidenced by the percentage results in the first cycle of 68.75% and in the second cycle to 80.1% and in the third cycle of 95.8%.Penelitian ini bertujuan untuk meningkatkan kemampuan bahasa anak Kelompok A dalam mengenal huruf vokal melalui media stiker dots. Penelitian ini menggunakan Pendekatan Penelitian Tindakan Kelas (PTK). Subjek penelitian ini adalah anak di kelompok A di TK Dharma Wanita Senden Kec. Kayen Kidul Kab. Kediri Jawa Timur yang berjumlah 6 anak. Objek penelitian ini adalah peningkatan kemampuan mengenal huruf vokal melalui media stiker dots. Metode pengumpulan data dilakukan melalui observasi dan dokumentasi. Teknik analisis data dilakukan secara deskriptif kuantitatif. Hasil penelitian menunjukkan adanya perubahan yang signifikan, yaitu peningkatan kemampuan mengenal huruf vokal. Hal ini dibuktikan dengan hasil persentase pada siklus I sebesar 68,75 % dan pada siklus II menjadi 80,1% dan di siklus III sebesar 95,8%.
Meningkatkan Kemampuan Fisik Motorik Halus Anak Melalui Kegiatan Kolase Kelompok B di Taman Kanak-Kanak
Authors: Yulinarti Tri , Bastiana Bastiana , Ramlah Sitti
Published: August 2022

The purpose of this study is to enhance the physical ability of the delicate mechanical children through collation in group b in kindergarten Aisyiyah XIII Pengawu, a type of study is the class action study (PTK ). The data collection tecniques used in this study are obseryations and documentation. The data analysis tecniquesused in reseach are quantitative data analysis. Away of extracting a sample used in this study is by seeing of observing a child’s ability through large picture media stimulus. The reseach subject was child group b of 10 children, consisting 4 boys and 6 woman. Registered in the 2020/2021 scholl year. Types the action study of this class is completed in two cycles 1 and cycle II. Based on data analysis it could be concluded that children’s fine motor skills in kindergarten Aisyiyah XIII Pengawu bodyguard through collage activities.Tujuan penelitian ini adalah untuk meningkatkan kemampuan fisik motorik halus anak melalui kolase pada anak kelompok B di TK Aisyiyah XIII Pengawu. Jenis penelitian dalah Penelitian Tindakan Kelas ( PTK ). Tehnik pegumpulan data yang digunakan dalam penelitian ini yaitu yang digunakan adalah observasi dan dokumentasi. Tehnik analisis data yang digunakan dalam penelitian adalah analisis data kuantitatif dan kualitatif. . Cara pengambilan sampel yang digunakan dalam penelitian ini adalah dengan melihat atau mengamati kemampuan anak melalui stimulus (rangsangan ) media gambar yang besar . Subyek penelitian adalah anak kelompok B dengan jumlah anak 10 anak, yang terdiri dari 4 anak laki-laki dan 6 anak perempuan yang terdaftar pada tahun pelajaran 2020/2021. Jenis penelitian tindakan kelas ini dilakasanakan dua siklus, yaitu siklus I dan siklus II, Berdasarkan hasil analisis data maka dapat disimpulkan bahwa kemampuan motorik halus anak di TK Aisyiyah XIII Pengawu melalui kegiatan penerapan kolase dengan berbagai media mengalami peningkatan setiap siklusnya.