bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Horizontal Gas-liquid Intermittent Flow Sub-Regimes Transitions: Physical Mechanisms and Flow Maps
Authors: Arabi Abderraouf , salhi Yacine , Zenati Youcef , Si-Ahmed El-Khider , Legrand Jack
Published: November 2023

These recent years, several experimental investigations were carried out on horizontal gas-liquid two-phase sub-regimes including plug, Less Aerated Slug (LAS) and Highly Aerated Slug (HAS) flows. Such classification is based on the shape of the elongated bubble/liquid slug interface as well as the aeration in the liquid slugs.
In this paper, an extensive experimental visualization was performed using air-water mixture in a 30 mm ID horizontal pipe covering a total of 189 operating conditions. It was reported, for the first time, that each sub-regime had a specific mechanism of aeration of the liquid slug flow. For instance, the presence of gas bubbles within liquid slugs, in case of plug flow, is due to the interfacial shear induced waves mechanism. The transitions to LAS and HAS flows are accompanied by the appearance of shearing-off and scooping mechanisms of bubbles, in the liquid film, into the liquid slug, respectively. In addition, the reported flow transition lines, as well as those existing in the literature, were analyzed using different existing coordinate systems. This analysis showed that the X-T system is the most suitable for predicting the three flow sub-regimes.
Moving from Transaction to Transformation to Address Non-Medical Drivers of Health: A thematic analysis of case notes from Community Health Workers
Authors: Poulos Natalie S. , Price Daniel , Paz Cindy , Mandell Dorothy J.
Published: November 2023

Background
Community Health Workers (CHWs) are frontline public health workers who are trusted community members and vital connectors to services that can address the major non-medical drivers of health. This study aims to examine the experiences of CHWs who are providing immediate and critical support to clients with health and social service needs to better understand how CHWs are supporting clients' development of strategies to address non-medical drivers of health.
Methods
Case notes from 95 high-risk clients who were seen by six community-based CHWs were included in the sample. All clients seen by these CHWs between March 2021 to July 2022 are included. Reflexive thematic analysis was used to identify themes that connected the experiences of CHWs.
Results
Two themes were identified. The first theme highlights the importance of trust between the CHW and the client to support change in non-medical social drivers of health. Case notes suggest trust is built in multiple ways including maintaining existing relationships within the community, approaching clients with compassion, and having a deep knowledge of the community. Trust between the CHW and the client allowed the CHW to better support the client to receive or enroll in services that could provide long-term change. The second theme focuses on the need for CHWs to move from a focus on crisis intervention to long-term behavior change among clients. Instances of long-term change are present in the data, yet it does not happen as frequently as it could or as frequently as CHWs hope that it would.
Conclusions
CHWs are providing instrumental support, while still struggling to function as agents of behavior change for clients. To improve the ability of CHWs to facilitate clients’ long-term behavior change, CHWs need to feel supported and encouraged to take time for trust building. Trust allowed CHWs to make the greatest impact and transformation of non-medical drivers of health.
Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella
Authors: Qu Zigang , Li Yuqiong , Li Wenhui , Zhang Nianzhang , Olajide Joshua Seun , Mi Xiaoyun , Fu Baoquan
Published: November 2023

The intracellular protozoan Eimeria tenella is responsible for avian coccidiosis which is characterized by host intestinal damage and death. During developmental cycle, E. tenella undergoes versatile transitional stages such as oocyst, sporozoites, merozoites as well as gametocytes. These developmental transitions involved changes in cell shape and cell size requiring cytoskeletal remodeling and changes in membrane proteins, which may require transcriptional and translational regulations as well as post-translational modification of proteins. Palmitoylation is a post-translational modification (PTM) of protein that orchestrates protein targeting, folding, stability, regulated enzymatic activity and even epigenetic regulation of gene expression. Previous research revealed that protein palmitoylation play essential role in Toxoplasma gondii, Trypanosoma cruzi, Trichomonas vaginalis and several Plasmodium parasites. Until now, there is little information on the enzymes related to palmitoylation and role of protein palmitoylation in E. tenella. Therefore, a palmitome of the second-generation merozoite of E. tenella was investigated. We identified a total of 2569 palmitoyl-sites that were assigned to 2145 palmitoyl-peptides belonging to 1561 protein-groups that participated in biological processes including parasite morphology, motility and host cell invasion. In addition, RNA biosynthesis, protein biosynthesis, folding, proteasome-ubiquitin degradation and enzymes involved in PTMs, carbohydrate metabolism, glycan biosynthesis and mitochondrial respiratory chain as well as vesicle trafficking were identified. The study allowed us to decipher the broad influence of palmitoylation in E. tenella biology, and thus lay a solid foundation to interpret its roles in the pathobiology of E. tenella infection. Raw data are publicly available at iProX with the dataset identifier PXD045061.
Factors affecting sweet potato (Ipomoea batatas (L.) Lam.) production practices in Northern and Southern Ethiopia
Authors: Aldow Ahmed , Feyissa Getachew Sime
Published: November 2023

Sweet potato (Ipomoea batatas (L.) Lam.) is a potential food security crop in the crop–livestock production systems for subsistence smallholder farmers in sub-Saharan Africa. This study assessed the social, ecological, and economic factors that influence sweet potato production in selected districts in Northern and Southern Ethiopia. The research site was stratified into low, middle, and high altitudes. A mixed method, consisting of quantitative and qualitative approaches, was used for data collection. A quantitative questionnaire was prepared and distributed to randomly selected farmer households, followed by qualitative in-depth interviews of key informants from research institutions, local agricultural offices, and researchers working in the study areas. In addition, informal interviews, transect walks, participation in planting, and discussions were used. In both sites, pests, diseases, drought, and lack of adaptable cultivars for different agro-ecological conditions influenced sweet potato production. In Northern Ethiopia, lack of adequate sweet potato knowledge of production practices and planting materials limited farmers from planting the crop widely. In Southern Ethiopia, farmers lost their sweet potato landraces because of the adoption and shifting to cultivating new high-yielding cultivars of sweet potato. This study suggests that farmers’ awareness and knowledge on the available cultivars and landraces as well as the relevant agronomical practices and performances should be improved. Moreover, participatory breeding programs for droughts, pests, and diseases tolerant, and nutrient rich and high - yielding cultivars are commendable.
MUC3A promotes the progression of Cholangiocarcinoma through the MAPK/ERK pathway
Authors: 冯 白洁 , 苏 伟 , Hu Lina , yu minghua
Published: November 2023

Aim
Cholangiocarcinoma (CCA) is the most common malignant tumor of the bile ducts. Due to its anatomical location, growth pattern, and lack of clear diagnostic criteria, it presents diagnostic challenges. Exploring its occurrence and development to find early markers and treatment targets is of great significance.
Methods
To determine whether Mucin 3A (MUC3A) can regulate the occurrence and development of cholangiocarcinoma cells and its mechanism, we constructed stable transfections of KONC (transfection negative control group) and MUC3A-KO1 and KO2 (transfection MUC3A knockout vectors) lentivirus in RBE cell lines. We investigated the effect of MUC3A on the proliferative capacity of cholangiocarcinoma cells using the CCK-8 assay and colony formation assay. The regulatory effect of MUC3A on the cell cycle of cholangiocarcinoma cells was examined using flow cytometry. The impact of MUC3A on the invasion and migration of cholangiocarcinoma cells was observed through scratch and Transwell assays. Additionally, the mechanism by which MUC3A regulates proliferation and metastasis of cholangiocarcinoma was explored using Western blot.
Results
MUC3A promotes the proliferation of cholangiocarcinoma cells by regulating the cell cycle. Additionally, MUC3A enhances the invasion and migration of cholangiocarcinoma cells by regulating the epithelial-mesenchymal transition(EMT). Furthermore, MUC3A regulates the proliferation and metastasis of cholangiocarcinoma cells through the ERK signaling pathway.
Conclusions
This study demonstrates that MUC3A regulates the proliferation and metastasis of cholangiocarcinoma cells through the ERK signaling pathway.
Long term results of a prospective multicenter obervational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study)
Authors: Finke Jürgen , Schmoor Claudia , Ayuk Francis , Hasenkamp Justin , Verbeek Mareike , Wagner-Drouet Eva , Biersack Harald , Schäfer-Eckart Kerstin , Wolf Dominik , Stuhler Gernot , Reibke Roland , Schmid Christoph , Kaufmann Martin , Eder Matthias , Bertz Hartmut , Grichina Olga
Published: November 2023

ATOS is a prospective observational study evaluating the outcome of patients receiving anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation. Primary endpoint was severe GvHD and relapse-free survival (SGRFS). GvHD prophylaxis consisted of ATLG and CSA/ MTX or MMF. Outcome was compared to the ATLG arm of our prospective randomized phase III multicenter trial trial (RCT).1, 2 165 patients with haematological malignancies were included. ATLG dose differed between centers (median total ATLG dose of 46 (IQR 32–60, range 15–91) mg/kg). Median follow-up was 70 months. As compared to the ATLG arm of our RCT, patients in ATOS were older, had a more advanced disease status, reduced intensity conditioning, HLA 10/10 match and PBSC transplantation were more frequent, given median ATLG dose was lower, and incidences of acute GvHD °III-IV (0.13), relapse (0.34), non-relapse mortality (0.23), and overall survival rates (0.52) were similar after 5 years. After adjusting for baseline differences, the largest difference in outcome was seen with respect to severe chronic GvHD (ATOS vs ATLG arm RCT: hazard ratio 2.79 [1.20, 6.51], p = 0.017). This long-term, multicenter, experience in routine clinical practice confirms the GvHD-protective effect of ATLG without compromising relapse and non-relapse mortality rates. Clinical Trial Registry: German clinical trials register DRKS00004581
Anatomical measurements of Vulva and Vaginal length for an Unselected Indian population : A Multi-centric Cross-Sectional Prospective Study
Authors: Mangla Mishu , Garg Priyanka , Purini Priyanka Yoga , Paul Sayanti , Rathod Sandhya Rani , Kanikaram Poojitha , S Sevala Kavya , Jarathi Aparna , Patnaik Nabnita , Sharmila Vijayan
Published: November 2023

Introduction
Female external genitalia also referred to as the ‘Vulva’ comprises the mons pubis, labia majora, labia minora, clitoris, urethra, vulva vestibule, vestibular bulbs, Bartholin's glands, Skene's glands, vaginal opening.The appearance and morphology of vulva is dependent on race, ethnicity, age, hormonal status, parity, and body mass index. The present study was therefore planned with the objective of Preparation of nomogram regarding measurements of the vulva and vagina in the Indian population and to find the correlation between the measurements of female external genitalia in the Indian population and their body mass index, age, parity, frequency of sexual intercourse.
Material and Methods
1562 women were recruited from the out-patient departments of four tertiary care centers from India, two from southern part of the country, one from north and one from the eastern part. Genital measurements were taken while in the lithotomy position. With the help of a reusable metal calliper with graduations, which could measure to 1/10 mm. Measurements were recorded as mean ± SD and centiles were also prepared. The correlation between age, height, weight, BMI, parity and the frequency of sexual intercourse was studied with the help of Spearman’s rank correlation coefficient.
Results
The mean length and width of labia majora are 9.7 ± 1.8 cm and 3.7 ± 0.8 cm respectively. Labia minora measures 5.7 ± 1.5 cm in length and 1.9 ± 0.7 cm in width. The mean length of the clitoris is 13.2 ± 4.5 mm and the mean width is 7.7 ± 3.1 mm. The perineal body measures 2.5 ± 0.7 cm. The average total vaginal length is 8.9 ± 1.4 cm.
Conclusion
The nomograms presented in the study can be used for reference range for counselling women undergoing any type of surgery on external genitalia including cosmetic gynecology surgeries. The centile curves can be used as reference ranges for women with different age and BMI.
Organophosphate Flame Retardants Exposure Predicts Epidermal Growth Factor Receptor Expression in Lung Cancer Patients: A Prospective Cohort Study
Authors: Chen Po-Ju , Lai Po-Chen , Lu Yueh-Chien , Pan Bo-Lin , Huang Wan-Ting , Kung Chia-Te , Chiang Jui-Chin , Cheng Fu-Jen , Wang Liang-Jen , Li Shau-Hsuan , Lee Wen-Chin , Ou Yu-Che , Wang Chin-Chou
Published: November 2023

Background:
Organophosphate flame retardants (OPFRs) have been widely distributed in our environment, and potential health hazards, including lung injuries from OPFR exposure, have been raised.
Methods:
The aim of the study was to investigate the distribution of OPFR exposure among lung cancer patients and its effects on epidermal growth factor (EGFR) expression. The current study enrolled 97 lung cancer patients, and their exposure to 10 OPFR compounds was evaluated using urine samples. Demographic and clinical features, along with urinary OPFR concentration, were compared based on the expression of EGFR gene. Spearman correlation was conducted to examine the relationship between OPFRs, while logistic regression was used to identify OPFR compounds that were independently associated with EGFR mutation.
Results:
OPFR exposure was found to be widespread in lung cancer patients, with an overall detection frequency of 98.81%. The urinary concentration of tris(2-butoxyethyl) phosphate (TBEP) was significantly lower in the group with EGFR mutation. TBEP showed an inverse relationship with mutant EGFR, particularly in the highest quartile when comparing to the lowest quartile (odds ratio 0.13, 95% confidence interval 0.03–0.65, p = 0.013).
Conclusions:
Exposure to OPFRs was prevalent in lung cancer patients. Among these pollutants, TBEP was identified as an independent inverse factor for the expression of EGFR mutation. Our study provides a reference for OPFR exposure in patients diagnosed with lung cancer and highlights the role of TBEP in evaluating EGFR mutation in this population.
Hybrid UM-LT-AHE Technique for Contrast Enhancement of Medical Images
Authors: Amusa Kamoli Akinwale , Idowu Olumayowa Ayodeji , Ilori Abolaji Okikiade
Published: November 2023

This paper is concerned with combinations of un-sharp masking, logarithmic transformation and adaptive histogram equalization techniques to arrive at a hybrid method for enhancement different types of medical image’ contrast. Motivation behind the hybridization is the need to have a contrast enhancement method that is not application specific and that can be deplored to several medical image enhancement. Four different types of medical images: X-ray, ultrasound, magnetic resonance and computer tomographic images are utilized in the evaluations of the proposed hybrid contrast enhancement method. As performance metrics, absolute mean brightness error, mean square error, peak signal to noise ratio and entropy are used. Comparative results both qualitative and quantitative, were conducted at the end of the research, and the proposed method out-perform other three (CLAHE, Fuzzy-based and Wavelet Transform-based) related selected methods in the field which used the same dataset in terms of testing accuracy. The enhancement quality of the proposed method was found to be satisfactory and can be used for any time of medical image, thus, the proposed hybrid technique produces better enhanced medical images from different medical image inputs.
Assessing the growth response to climate of Douglas fir under European temperate oceanic conditions
Authors: Guisset Camille , Ponette Quentin , Vincke Caroline
Published: November 2023

Douglas-fir has been largely introduced in Europe due to its high productivity. Although it is considered as a relatively drought tolerant species, its ability to cope with climate change remains uncertain. This study aims to investigate Douglas fir growth response to climate in its current climatic optimum in Europe. A total of 720 cores were taken from 360 trees in 24 adult Douglas fir stands in the Belgian Ardennes, spanning a range of annual climatic water balance (368–700 mm), estimated maximal soil extractable water reserve, and stand basal area (30–53 m²/ha). Climate-growth relationships over the 1976–2020 period were investigated through Bootstrapped Correlation Coefficients (BCCs) calculation on detrended chronologies. Principal Component Analysis was computed on the BCCs to explore how growth response could be modulated according to the three above-mentioned site and stand characteristics. Radial growth was favoured by mild and wet late winters-early springs; warmer temperatures at the end of the growing season and in winter; and wetter early summers. The studied site and stand conditions did not influenced these climate-growth relationships, indicating a strong tree species response to climate. BCCs computed on moving windows showed an increased Douglas fir sensitivity to summer water deficit over time, which could offset its ability to benefit from higher temperatures in the late growing season and in winter in the future.
Parental education and child development: long and short term outcomes
Authors: Jacob Nikita
Published: November 2023

There has been growing evidence of educational attainment of spouses on marriage, dissolution and fertility patterns, economic well-being, family investments in children as well as parenting practises and standards. This paper, using the Panel Study of Income Dynamics, examines the relationship between educational homogamy of spouses on child’s outcomes which is measured by college enrollments and college graduation for children between 18-28 years of age. Using variation in the timing of implementation of joint child custody and unilateral divorce laws across the United States, I find that if the spouses are similar in their educational attainment levels, the propensity of their children enrolling in college increases. Thus, suggesting that spouses with similar educational levels are perhaps less likely to face frictions in terms of household management and therefore more likely to strategically invest in their childrens future.
The role of the BELL1-2 transcription factor in the development of legume-rhizobial symbiosis
Authors: A.V. Dolgikh , E.S. Kantsurova , A.M. Dymo , E.A. Dolgikh
Published: November 2023

Nodule development is a process that is tightly regulated by phytohormones, mainly gibberellins and cytokinins. During nodule development gibberellins and cytokinins play an important role in the infection development and organogenesis. However, the interaction between these phytohormones is not yet clear. In our research we first demonstrated that the BELL1-2 transcription factor can influence gibberellin and cytokinin biosynthesis genes during nodule development. It was also found that BELL1-2 can regulate SHY2-like gene which is specifically involved in the control of meristem maintenance and organogenesis. Localisation of the expression of the pMtBELL1-2::GUS promoter showed that the gene is expressed in the primordia, as well as in the infection zone and the nitrogen-fixing zone of mature nodules. Furthermore, we detected an increase in the infection zone in M. truncatula nodules with BELL1-2 RNAi due to the modified growth of the infection threads. In summary, we conclude that BELL1-2 plays an important role in the control of infection and organogenesis in legume plants.
Dynamical mean field theory for models of confluent tissues and beyond
Authors: Kamali Persia Jana , Urbani Pierfrancesco
Published: November 2023

We consider a recently proposed model to understand the rigidity transition in confluent tissues and we derive the dynamical mean field theory (DMFT) equations that describes several types of dynamics of the model in the thermodynamic limit: gradient descent, thermal Langevin noise and active drive. In particular we focus on gradient descent dynamics and we integrate numerically the corresponding DMFT equations. In this case we show that gradient descent is blind to the zero temperature replica symmetry breaking (RSB) transition point. This means that, even if the Gibbs measure in the zero temperature limit displays RSB, this algorithm is able to find its way to a zero energy configuration. We include a discussion on possible extensions of the DMFT derivation to study problems rooted in high-dimensional regression and optimization via the square loss function.
Growth and yield of soybean plants under water deficit and application of foliar fertilizer
Authors: Santos Brenner Cabalheiro dos , Silva Marcelo Caixeta , Cardoso Nathália Carvalho , Troncha Matheus Felipe Alves Costa , Júnior Robson José Ferreira , Caixeta Luiz Gustavo de Oliveira , Borges Larissa Pacheco , Matos Fábio Santos
Published: November 2023

The objective of this work was to assess the effects of a commercial foliar fertilizer (H2 Protector; H2 Agrosciences, Orizona, Brazil) on growth and yield of soybean plants grown under water deficit. The experiment was conducted for 105 days from November 2021 to February 2022 in a greenhouse at the State University of Goiás, in Ipameri, GO, Brazil. A completely randomized design was used, with a 2×5 factorial arrangement and three replications. The first factor consisted of foliar fertilizer rates (0 and 300 mL ha-1), and the second factor consisted of water depths applied to the plants (25%, 50%, 75%, 100%, and 125% of the daily evapotranspiration). Morphological variables and agronomic components of the crop were analyzed at 60 and 90 days after emergence. Water deficit at the R5 reproduction stage limits the growth and yield of soybean plants. The important results found for vegetative and reproductive growth of plants treated with the foliar fertilizer were due to the greater number of leaves and transpiration of these plants, even under water deficit, denoting a higher photosynthetic potential. The foliar fertilizer did not mitigate water deficit effects on soybean plants grown in pots, but denoted potential for mitigation of damages in the field
Artificial neural networks based on segmented model for adaptability and stability evaluation of soybean genotypes
Authors: Barbosa Wagner Faria , Hashimoto Thais do Prado , Matsuo Éder , Nascimento Ana Carolina Campana , Azevedo Camila Ferreira , Bezerra André Ricardo Gomes , Nascimento Moysés
Published: November 2023

Unlike models based on simple linear regressions, segmented models can better assess the adaptability and stability of genotypes, demonstrating a nonlinear response pattern over environmental variation. However, these methods can be under statistical limitations, such as the Type Error II increase and biased estimates. Therefore, this work aimed to transpose the concepts of adaptability and stability from the statistical analysis of a segmented model to the discriminatory potential of an artificial neural network (ANN) and use it to classify soybean (Glycine max (L.) Merr.) genotypes. An ANN training was carried out with the grain yield of 7,200 soybean genotypes simulated in 15 different environments. The ANN topology chosen was the one that had less than 1% of error in the testing phase with 1,800 simulated genotypes. A total of 9,000 simulated soybean genotypes were previously arranged in 18 different classes, which represented the combination of nine classes of adaptability by the Verma and collaborators (VCM) method and two classes of stability (invariability concept) by the Finlay & Wilkinson (FW) method. Finally, the grain production of ten real soybean genotypes was inputted into the ANN-trained model, and the classification regarding adaptability and stability was obtained. There was 90% agreement between the ANN and VCM analyses regarding the adaptability classification and 20% regarding stability. With the methods presented in this work, it was demonstrated that the potential of using ANNs to assess the adaptability of genotypes is strong. In addition, since stability was introduced in the ANN as a different concept from that used to classify the genotypes by the statistical method, such classification needs to be reviewed and further improved
Antixenosis and antibiosis to Spodoptera frugiperda (Lepidoptera Noctuidae) in sunflower genotypes
Authors: Miranda Guilherme Gual, Débora de Sousa , Almeida André Cirilo de Sousa , Cunha Paulo Cesar Ribeiro da , Jesus Flávio Gonçalves de
Published: November 2023

Sunflowers are grown in various countries throughout the world and used for cooking oil, biodiesel, animal feed and as ornamental plants. Spodoptera frugiperda (JE Smith) is a polyphagous insect species that is native to tropical America and that has spread rapidly around the world. The purpose of the current study was to evaluate resistance of sunflower genotypes to S. frugiperda . This was accomplished by assessing antibiosis and antixenosis in 25 sunflower genotypes. Were evaluated: free and no-choice attractiveness test, larval stage: period and viability of the larval stage and weight of caterpillars at ten days of age; pre-pupa stage: period and viability; pupal stage: period, weight at 24 hours of age and viability; complete cycle: period and viability; adult stage: daily longevity assessments and sex ratio; nutritional parameters The BRS 55 and BRS 64 genotypes showed antixenosis resistance in choice and no-choice tests. Biological and nutritional measures demonstrated that the BRS 323, BRS 56, BRS 65 genotypes were unfavorable to S. frugiperda development. These genotypes showed moderate resistance and could be used by sunflower growers as a way of controling S. frugiperda.
Foliar application of chitosan and plant probiotic bacteria influencing the growth, productivity and bulb storage life of onion
Authors: Ray Tithy , Gomasta Joydeb , Hassan Jahidul , Hossain Md. Shamim , Kayesh Emrul
Published: November 2023

Onion having several health promoting phytochemical contents is an important spices in most of the countries of the world as well as vegetables in particular and chitosan and plant probiotic bacteria are few proven natural growth enhancing agents. Here, three bio-stimulants namely Chitosan (100 and 200 ppm), Paraburkholderia BRRh-4 bacteria (1.5 × 109 CFU mL-1) and Clybio (0. 1%) in singly as well as combining one another were applied at twelve different treatment combinations including control with the aim of investigating the below and above ground vegetative growth, bulb productivity and post-harvest storage performance of onion cv. “Taherpuri”. The experiment was set up in Randomized Complete Block Design (RCBD) maintaining three replicates and conducted during November 2019 to June 2020 where the bio-stimulant formulations were sprayed in the foliage at 20, 40 and 60 days after transplanting (DAT). Reproductive behaviors of the onion cultivar differed significantly among the treatments and those were the resultants of statistically varied vegetative performances recorded at 30, 60 and 90 DAT. Chitosan @ 100 ppm + Clybio (0.1%) + Paraburkholderia BRRh-4 (1.5 × 109 CFU mL-1) combination exhibited statistical superiority over the other treatments in terms of plant height (53.230 cm), number of leaves (10.13/plant), leaf length (41.20 cm) and diameter (10.33 mm), number of roots (32.53/plant), root length (12.23 cm), neck and bulb diameter (11.20 mm and 4.83 cm, respectively) and bulbing ratio (0.23) at 90 DAT. While, shoot and root growth didn’t vary significantly at earlier stages (at 30 DAT). Again, the highest yield (3.36 kg/plot and 10.45 t/ha) was also obtained from Chitosan @ 100 ppm + Clybio (0.1%) + Paraburkholderia BRRh-4 (1.5 × 109 CFU ml-1) treatment. The combination of chitosan and probiotic bacteria had significant influence on post-harvest storage qualities of onion where the longest shelf life/marketable life (8.17 months) with the lowest physiological weight loss and bulb rotting at 90 days after harvest was administered in Chitosan @ 100 ppm + Clybio (0.1%) + Paraburkholderia BRRh-4 (1.5 × 109 CFU mL-1) treatment. Besides the best treatment, Chitosan @ 100 ppm + Clybio (0.1%) and Chitosan @ 100 ppm + Paraburkholderia BRRh-4 (1.5 × 109 CFU mL-1) produced statistically superior results over control for onion growth and development. Therefore, chitosan and plant probiotic bacteria can be judiciously used for quality onion production in the warm and humid areas of the world
Pedagogías ante la desaparición.
Authors: Martínez Miguel Angel
Published: November 2023

El proyecto educativo nacional busca establecer una cultura democrática, integral e inclusiva que aborde los problemas estructu­rales que el país padece, tal y como lo afirma y promueve la Nueva Escuela Mexicana (NEM). Sin embargo, las estrategias educativas reproducen discursos hegemónicos, así como marcos de comprensión y valoración normativos que consolidan las violencias estructurales que asedian los cuerpos y los territorios. A partir de la participación observante en el eje de escuelas en las brigadas nacionales de bús­queda de personas desaparecidas en México se plantea un análisis crítico de la educación formal desde una pedagogía ante la desaparición, que abre posibilidades para una educación ante las víctimas de graves violaciones a los derechos humanos, como atestiguan las personas en situación de desaparición forzada. Este planteamiento ofrece alternativas a los marcos de normalización de la violencia, la precarización y el desprecio de sectores vulnerados de manera sistemática. Desde tales coordenadas, el texto se ubica desde la fi­losofía de la educación interseccional, en clave anamnénica, como herramienta de restauración de situaciones históricas tensadas por la violencia y como dispositivo que favorece la construcción de una cultura de la paz.
Level of Well-Being among School Going Adolescents
Authors: Sakthivel Rajathi
Published: November 2023

The adolescence state is the progressive transition from childhood to adulthood. They have specific needs which vary with gender, life circumstances, and socioeconomic level. In this stage, they suffer from various forms of problems and conflicts, which ultimately impair normal development and move to a depressive state. This study assessed the level of well-being among school-going adolescents in the south region of Tamilnadu; The uni-variable, descriptive- cross-sectional research design was adopted. Through the convenient sampling technique,120 school-going adolescents responded to the adolescent’s well-being questionnaire (11-16 years) through online Google forms. The collected data were analyzed through the SPSS package. In the results, the majority of school-going adolescents (77%) were depressed and there is a significant association found between gender and grade (P= 0.05%). The nursing fraternities of community and public health nurses and stakeholders in the community take the initiation of remedial measures to support and promote the mental health of adolescents. Keywords: Well-being, School going Adolescents, Conflicts, Depression, and mental Health.
Domínios das Competências Essenciais de Promoção da Saúde LGBT na Formação Acadêmica de Enfermagem
Authors: Silva Caik Ferreira , Bezerra Sáskya Jorgeanne Barros , Magalhães Beatriz de Castro , Silva Mauro Mccarthy de Oliveira , Calou Cinthia Gondim Pereira , Quirino Glauberto da Silva , Albuquerque Grayce Alencar
Published: November 2023

Objetivo: Identificar os domínios das competências essenciais de promoção da saúde do Competencies Health Promotion Project (CompHP) desenvolvidos na formação acadêmica de enfermagem ante a saúde LGBT. Método: Estudo descritivo e qualitativo desenvolvido em três Instituições de Ensino Superior do interior cearense do Brasil, entre julho e dezembro de 2020, com 84 acadêmico(a)s de enfermagem, por meio de questionário on-line. Os dados foram organizados mediante análise de conteúdo temática e analisados pelo aporte teórico metodológico CompHP. Quanto aos aspectos éticos, o estudo obteve parecer satisfatório. Resultados: A idade do(a)s acadêmico(a)s variou entre 21 e 47 anos, em sua maioria do sexo biológico feminino; mulheres cisgênero; heterossexuais; de universidades privadas e matriculado(a)s no nono semestre. Identificaram-se oito domínios do CompHP: Possiblidade de Mudanças; Advocacia em Saúde; Parceria; Comunicação; Liderança; Diagnóstico; Implementação e Avaliação e Pesquisa, sendo o domínio Planejamento não identificado. Os(as) estudantes conseguem identificar as demandas de promoção da saúde do público LGBT, no entanto, mesmo na presença dos domínios, mencionam a necessidade de maior discussão sobre a temática. Conclusão: Identificou-se a presença de oito dos nove domínios do CompHP na formação do(a)s acadêmico(a)s de enfermagem, o que sugere que esse(a)s possam atuar enquanto agentes promotores de saúde à população LGBT.
Strategizing the Digital Transformation of Oil and Gas Enterprises
Authors: Beketova Olga
Published: November 2023

Digital transformation provides energy security and environmental safety, as well as sustainable growth and competitiveness. In the oil-and-gas extraction industry, effective digital transformation requires detailed strategizing. In this sphere, the goals of digital transformation include observability, manageability, flexibility, adaptability, platform sales technologies and services, etc. This article introduces an organizational and economic tool for strategizing the digital transformation of oil-and-gas enterprises. The research relied on the theory and methodology of strategizing developed by Professor V.L. Kvint, who approaches strategy as a systemic, multidisciplinary, and multidimensional phenomenon that integrates national, regional, sectoral, and corporate strategies. The study involved standard research methods, e.g., generalization, scientific abstraction, analysis, synthesis, comparison, etc. The author classified theoretical approaches to strategizing in the digital economy and identified its specifics in the oil-and-gas extraction industry. Digital strategizing was tested for threats and opportunities in order to build a structural and logical model of a digital transformation strategy for an oil-and-gas enterprise. The model provides a unity of goals, stages, actions, and results for long-term strategic development. Continuous digital strategizing of business models is a key to success in the oil-and-gas extraction industry.
La reparación de los daños causados por la persecución de un enjambre de abejas en fundo ajeno previsto en el artículo 612 del Código Civil español. Un supuesto de las denominadas "indemnizaciones o compensaciones por sacrificio"
Authors: Céspedes Muñoz Carlos
Published: November 2023

Existe un conjunto de supuestos en que la ley, autorizando expresamente un determinado comportamiento, ordena que en el evento de que de ello se derive un daño, su autor deba indemnizarlo. Tales casos se denominan normalmente bajo el equívoco rótulo de “responsabilidad por acto lícito”, siendo una de sus hipótesis más características el de la indemnización por los daños causados por la persecución de un enjambre de abejas propio en fundo ajeno. A través del presente trabajo constataremos que se trata de un supuesto de las “indemnizaciones o compensaciones por sacrificio”, que no constituye responsabilidad civil alguna y que sólo da derecho a la reparación del daño patrimonial que haya sido necesario para el ejercicio del derecho en cuestión.
Considerações acerca dos conceitos de autorreflexão e emancipação na pesquisa-ação
Authors: Soares Fernandes Letícia , Ladislau Prederigo Allana , Carlos Queiroz Rafael , Falcão Santana Gustavo , Lima de Almeida Mariangela
Published: November 2023

Toma-se como objetivo tecer considerações acerca do conceito de autorreflexão e emancipação, entrelaçando-o à pesquisa-ação, por meio do diálogo entre Jürgen Habermas, Theodor W. Adorno, Wilfred Carr e Stephen Kemmis. Os conceitos de autorreflexão e emancipação surgem na Escola de Frankfurt através de Adorno e são incorporados por Habermas, que dá outro sentido a eles. Carr e Kemmis, ao refletirem sobre a pesquisa-ação emancipatória na educação, tomam Habermas como alicerce e constituem o conceito de autorreflexão crítica. A partir das considerações dos autores, o artigo reflete acerca da autorreflexão incorporada na metodologia da pesquisa-ação, principalmente no tocante à formação continuada de profissionais da educação. À luz dos pressupostos habermasianos, defendem-se os conceitos de autorreflexão e emancipação pela via da ação comunicativa, na qual o paradigma da consciência é transposto para o paradigma da linguagem. Compreende-se que para Adorno a autorreflexão está atrelada diretamente à liberdade, ao pensamento crítico e à autonomia, que guiam o indivíduo para a emancipação. Enquanto para Habermas, a autorreflexão vincula-se à linguagem e à comunicação, entre dois ou mais sujeitos, que os guiam para a emancipação. Carr e Kemmis inspirados na espiral cíclica proposta por Lewin e na autorreflexão de Habermas, vão defender a espiral autorreflexiva na pesquisa-ação. Diante disso, entende-se que os problemas da educação têm na racionalidade comunicativa perspectivas de mudanças sólidas, especialmente pela via de processos formativos.
racionalidade comunicativa como pressuposto na formação continuada de gestores de educação especial
Authors: Ladislau Prederigo Allana , Soares Fernandes Letícia , Lima de Almeida Mariangela
Published: November 2023

O trabalho tem como objetivo geral evidenciar a formação continuada de profissionais da educação a partir das contribuições dos pressupostos habermasianos no tocante à racionalidade comunicativa. Advoga-se acerca da necessidade de pensar novas formas de realizar ações formativas com os profissionais da educação, que os tomem como autores da sua própria prática e sujeitos ativos de conhecimento, por meio da pesquisa-ação colaborativo-crítica e da ação comunicativa de Habermas. Constitui-se como um recorte de um trabalho de conclusão de curso, que teve como foco analisar a trajetória de um grupo de estudo-reflexão com gestores de educação especial no estado do Espírito Santo. Toma Jürgen Habermas como referencial teórico-epistemológico, a partir da Teoria da Ação Comunicativa e dos conceitos de racionalidade comunicativa e instrumental. Como metodologia de pesquisa tem a análise documental dos documentos relativos ao grupo de estudo-reflexão, tais como relatórios e transcrições. Os dados evidenciam a mudança de postura, concepções e práticas dos profissionais envolvidos ao longo dos anos. Os gestores puderam construir ações formativas tanto para os profissionais da educação que atuam nas suas redes de ensino, quanto para si mesmos, de modo coletivo e colaborativo.
fenomenologia de Habermas e suas contribuições para a hermenêutica
Authors: Gomes Sandro roberto de Santana , Menezes Anderson de Alencar
Published: November 2023

A fenomenologia no pensamento de Jürgen Habermas e suas contribuições para a hermenêutica representam uma abordagem crítica e engajada na compreensão do Mundo da Vida e da interpretação dos fenômenos sociais. Habermas enfatiza a importância da intersubjetividade e da comunicação autônoma na construção do conhecimento e na formação de significados compartilhados. Ele crítica a hermenêutica tradicional por negligenciar a dimensão social da interpretação e propõe uma hermenêutica emancipatória que busca revelar as estruturas de poder e as ideologias presentes na sociedade.  Suas contribuições incluem a ênfase na comunicação discursiva, na crítica ideológica e na promoção da participação democrática na interpretação das vibrações comunicativas e dos contextos sociais. A fenomenologia no pensamento de Habermas destaca a importância da intersubjetividade e da comunicação na construção do conhecimento e na formação de significados compartilhados. Ele enfatiza que a linguagem e a interação social são essenciais para a reconstrução da Democracia, permitindo uma troca de perspectivas e a construção de consensos em torno da justiça social.
Sobre o político da informação
Authors: Medeiros Jackson da Silva
Published: November 2023

O trabalho busca suscitar questões e inferências sobre a utilização de plataformas digitais de comunicação, como conformações capitalistas entendendo que esses ambientes agem na incorporação de significações, com seus sentidos, na mediação de um sistema ideológico-discursivo que age nos sujeitos e na sociedade. Para tal, situa a informação como um dispositivo, um infômato que sempre medeia e armazena e é capaz de formar e ser formada, alicerçada em conjuntos de pertencimentos em contínuos significados compartilhados. Reflete sobre a compreensão discursivo-ideológica da informação, sua capacidade de agir como máquina performativa. Ao olhar para uma ontologia sobre o político da informação é possível reconhecer uma reflexão crítica sobre as mediações que constituem a informação enquanto objeto social.
Comunicação desfigurada pela violência e reconstrução da democracia
Authors: Menezes Anderson de Alencar , Araujo Alda de Barros
Published: November 2023

O objetivo desse trabalho é apresentar a análise de caso experenciado pelos coautores em Unidade de Acolhimento em Maceió que recebe crianças de 0 a 6 anos em razão de desamparo e abandono. Foi utilizada a metodologia do estudo de campo, qualitativo, do tipo pesquisa-ação, a partir de visitações ao LACA. Pensar essa perspectiva a partir das relações entre Habermas, Freud e Winnicott, em uma relação entre Filosofia e Psicanálise a partir de processos comunicativos desfigurados pela violência e a urgência de postular processos reconstrutivos democráticos em que as ações linguísticas salvaguardem a integridade das crianças que viveram experiências deploráveis e foram rasuradas por comunicações desconfiguradas por diversos tipos de violências: físicas, psíquicas e emocionais. Concluiu-se que as crianças de tenra idade já apresentam comunicação desfigurada pela violência e que as relações consitutivas entre Estado de Direito Democrático e Justiça Social são forças constitutivas e imprescindíveis para a proteção dos seres humanos em níveis profundos de vulnerabilidades sociais.
The Novel Prognostic Biomarker MAPK12 Promotes Migration, Proliferation,
and Invasion in Head and Neck Squamous Cell Carcinoma
Authors: Cheng Yuxi , Liu Tianyi , Li Manyu , Chen Juan , Fang Xiaodan , Tang Zhangui
Published: November 2023

Background::

The prognosis and survival rate of patients with head and neck
squamous cell carcinoma (HNSCC) remain a serious public health concern. Therefore,
elucidation of the underlying mechanisms responsible for the biological behavior of HNSCC
is crucial for the development of effective treatment strategies.

Methods and Materials:

In this study, we analyzed the TCGA database and found that
MAPK12 was overexpressed in tumor samples compared to normal samples, which was
confirmed by microarray expression profiles, quantitative real-time polymerase chain reaction,
and immunohistochemistry.

Results::

Cell functional experiments, including the cell counting kit-8 assay, wound
healing test, and Transwell assay, revealed that MAPK12 overexpression increased the
proliferation, invasion, and migration of HNSCC cells. A correlation was observed between
MAPK12 expression and patient survival in HNSCC across several clinicopathological
variables, including disease grade and stage. Analysis of immune-related functions
demonstrated that HNSCC patients with low MAPK12 expression had a more favorable
tumor immune microenvironment and better immunological functions.

Conclusion::

Collectively, our study identified for the first time that MAPK12 is upregulated
in HNSCC, functioning as an oncogene, indicating a suppressive tumor immune
microenvironment and poor prognosis since it could promote cancer cell proliferation,
invasion, and migration. However, further studies are needed to gain a more comprehensive
understanding of the role of MAPK12 in HNSCC and other tumor types.
Knockdown of LRCH4 Remodels Tumor Microenvironment Through
Inhibiting YAP and TGF-β/Smad Signaling Pathway in Colorectal Cancer
Authors: Li Zhiwen , Cui Zhenhua , Wang Xianren , Lv Yanfeng
Published: November 2023

Background::

Colorectal cancer is one of the most common gastrointestinal malignancies
worldwide. LRCH4 is the top 1 gene associated with an unfavorable prognosis in colorectal
cancer.

Methods::

Here, we reported that the knockdown of LRCH4 inhibited the proliferation, migration
and invasion in HT29 cells.

Results::

The activity of Yes-Associated Protein (YAP), a transcription factor in the Hppo-YAP
signaling pathway, was significantly inhibited by LRCH4-siRNA. LRCH4 knockdown also reversed
the EMT and regulated the expression of extracellular matrix (ECM) protein, Fibronectin
and Collagen IV in HT29 cells. In addition, the TGF-β/Smad signaling pathway, as the downstream
pathway of Yap, was also inhibited by LRCH4 knockdown.

Conclusion::

Knockdown of LRCH4 involved in the regulation of ECM and EMT and inhibited YAP
and the TGF-β/Smad signaling pathway in colorectal cancer cells. Our study provided a mechanism
of LRCH4 on colorectal cancer cells, and a new potential target for clinical tumor treatment