bluuebunny/crossref_metadata_2025 huggingface dataset:
La conciliación prejudicial en asuntos de nulidad y restablecimiento del derecho contra actos administrativos que deciden sobre derechos de propiedad industrial a la luz del nuevo Estatuto de Conciliación
Authors: Portilla Mogollón Eliana Andrea , Villarreal Márquez Melissa
Published: June 2023

La Ley 2220 de 2022 eliminó la restricción de la conciliación a asuntos de contenido económico, con lo cual se generó la carga de agotar la conciliación prejudicial como requisito de procedibilidad en medios de control de nulidad y restablecimiento del derecho contra actos administrativos que deciden sobre derechos de propiedad industrial. Este cambio normativo ha mostrado también la heterogeneidad en la interpretación de las entidades competentes sobre la naturaleza conciliable —o no— de este tipo de conflictos, y de la cual dependerá si debe agotarse el trámite conciliatorio o si debe expedirse una constancia de asunto no conciliable. Este artículo pretende determinar si, a pesar de la modificación normativa, en este tipo de conflictos procede adelantarse el trámite conciliatorio o no.
Know-how o secreto empresarial. A propósito del nuevo Código de Comercio de Ecuador
Authors: Gómez Velasco Xavier
Published: June 2023

El presente artículo analiza la figura del know-how como se encuentra caracterizada en el Código de Comercio de 2019, contrastándola con aquella del secreto empresarial que ya se encontraba arraigada en nuestra legislación mucho antes de la expedición de dicho Código. Conforme demuestra el análisis, la principal diferencia que podría establecerse entre ambas figuras reside en su ámbito de aplicación, que es mayor en el secreto empresarial. En consecuencia, la introducción del know-how en el Código de Comercio parece innecesaria e inconveniente, pues lo adecuado hubiese sido que el Código se refiriese al secreto empresarial en lugar de al know-how.
Importance of Clinical Judgment Skill Competencies Across Practice Settings: Certified Rehabilitation Counselors’ Perceptions
Authors: Austin Bryan S. , Lee Chun-Lung , McCarthy Amanda , Sprong Matthew
Published: June 2023

Accurate clinical judgments are critically important for counselors in their work with clients. To date, there are no studies that have assessed rehabilitation counselors’ knowledge of clinical judgment and its importance to implement in practice. In this internet-based study, a random sample of certified rehabilitation counselors (CRCs;n= 579) were surveyed using the clinical judgment skill inventory (CJSI). The CJSI measures clinical judgment skills across seven clinical judgment skill areas (scientific attitude, cognitive complexity, cultural bias, confirmatory bias, memory bias, negative bias, and evidence-based practice). CRC participants overall rated clinical judgment skills to be important. Significant multivariate analysis of variance (MANOVA) test indicated significant mean differences between practice settings (Wilks’ LambdaF= 3.31,pvalue <.01) in “scientific attitude” (F-statistic = 3.91,pvalue <.01), “cultural bias” (F-statistic = 3.71,pvalue <.01), “confirmatory bias” (F-statistic = 3.02,pvalue = .01), and “evidence-based practice” (F-statistic = 5.62,pvalue <.01). Specifically, CRCs working for a college or university perceived clinical judgment skill areas to be more important than CRCs working in other practice settings. Implications for rehabilitation counseling practice are discussed.
The Assessment of Clinical Rehabilitation Counseling Competencies
Authors: Lambie Glenn W. , Frawley Caitlin , Haugen Jaimie Stickl , Wiand Dylan
Published: June 2023

The Assessment of Clinical Rehabilitation Counseling Competencies (ACRCC) is an evaluation tool intended to assess clinical rehabilitation counseling trainees’ developing competencies, specialty-specific skills, and learning outcomes. In response to the 2017 merger between the Council for Accreditation of Counseling and Related Educational Programs (CACREP) and the Council on Rehabilitation Education, we developed the ACRCC to align with the CACREP (2016)Standards. In our manuscript, we review (a) the developmental needs of rehabilitation counseling trainees, (b) the importance of comprehensive and specialty-specific clinical evaluation measures, (c) the development of the ACRCC, and (d) the opportunities for future research and implications for counseling preparation programs.
Análisis de errores gramaticales en la distinción escrita del género en francés.
Authors: Peralta Gerónimo Nayeli del Carmen , Rojas León Perla del Rocío
Published: June 2023

Este artículo esboza un análisis de errores gramaticales relacionados con la distinción de género gramatical en la escritura de aprendices de francés como Lengua Extranjera (LE), con el fin de identificar aquellos aspectos gramaticales en donde dichos errores son más recurrentes, así como analizar las posibles causas y factores que los originan. La investigación se realizó con una muestra de 30 estudiantes de la Licenciatura en Idiomas en la Universidad Juárez Autónoma de Tabasco, a quienes se les aplicó un cuestionario sobre el tema para analizar, además de los errores, sus perspectivas sobre la distinción del género en las palabras y la similitud entre el francés y el español. Se concluye que en cierta medida la influencia de la Lengua Materna (LM) ocasiona interferencia gramatical, pero también existe una variedad de errores de origen intralingüístico relacionados con la competencia lingüística del aprendiz.
The IMPLEMENTATION OF PjBL TO INCREASE STUDENTS' LEARNING ACTIVITY AND MOTIVATION AT SMA MUHAMMADIYAH 3 JEMBER
Authors: Jannah Arminatul , Mahfud Mohamad Zaenal , Komarayanti Sawitri
Published: June 2023

This research was conducted with the aim of improving the engagement and motivation in learning biology through the implementation of a project-based learning model, namely Project Based Learning, among students of class XB at SMA Muhammadiyah 3 Jember. Project Based Learning is a contextual learning model that uses projects as a medium, with the expectation of transforming students' learning methods to be more independent by increasing their engagement and motivation. This study employed a classroom action research consisting of three cycles. Data analysis was carried out using quantitative descriptive analysis, and data collection was carried out through observation sheets, questionnaires and documentation. The steps in implementing the Project Based Learning model include determining fundamental questions, designing project plans, creating a schedule for producing the project outcomes, monitoring project engagement and progress, testing the outcomes, and evaluating the learning experience. The results of the study showed that the application of Project Based Learning was able to improve student engagement by 4% and 10%, reaching 62% in cycle 1 and progressively increasing to 66% in cycle 2 and 76% in cycle 3. Student motivation also increased by 4% and 11%, reaching 63% in cycle 1, and further increasing to 67% in cycle 2 and 78% in cycle 3. Therefore, Project Based Learning is recommended for implementation in biology education.
IMPLEMENTASI PEMBELAJARAN BERDIFERENSIASI MELALUI PBL UNTUK MENINGKATKAN KEMAMPUAN LITERASI SAINS SISWA KELAS X.3 SMAN RAMBIPUJI
Authors: Tilamsari Balkis Yuliar , Komarayanti Sawitri , Purwaningsih Sri
Published: June 2023

Literacy skills are needed by students in the rapid development of information and communication technology, and the internet. The results of the latest PISA survey showed low students' reading ability when compared to the previous year. This study aims to improve the scientific literacy skills of class X.3 students of SMAN Rambipuji by applying differentiation learning through problem-based learning. The type of research used is the action research class which consists of the planning, implementation, observation and reflection stages. The subjects in this study were students of class X.3 at SMAN Rambipuji Jember which consisted of 36 students. Data were obtained from interviews, observations, documentation, and tests in the form of post-test questions which contained indicators of scientific literacy. The results showed that there was an increase in scientific literacy skills of X.3 class students from an average score of 54.6 to 70.3 when differentiated learning was applied through problem-based learning in cycle I and cycle II
PENERAPAN MODEL PEMBELAJARAN PBL MENGGUNAKAN MEDIA FLIPBOOK UNTUK MENINGKATKAN HASIL BELAJAR BIOLOGI SISWA SMAN AMBULU
Authors: Virdarani Nira
Published: June 2023

This study aims to determine the increase in biology learning outcomes for class XI MIPA 1 SMAN Ambulu in the 2023/2024 academic year through the application of the Problem Based Learning (PBL) model using Flipbook media. This is interesting to study further because the learning process has not varied so that students are less enthusiastic and more easily bored so that it affects learning outcomes. This research is a classroom action research which consists of three cycles, namely pre-cycle, cycle I and cycle II. The subjects of this study were 36 students in class XI MIPA 1 at SMAN Ambulu. Sources of data obtained from observations, post-tests, and learning outcomes. Data analysis was performed using descriptive analysis techniques. After taking action using the PBL learning model using Flipbook media, it is known that the percentage of completeness of student learning outcomes has increased. The percentage of completeness of student learning outcomes during the pre-cycle was 56%, then in cycle I the percentage of completeness increased to 72%, then in cycle II the percentage of completeness again increased to 78% of the total number of 36 students. Based on the results of these data, it can be concluded that Flipbook media can improve student learning outcomes in class XI MIPA 1 SMAN Ambulu in biology subjects.
Basic Methodology for Selecting and Substantiating Iraqi Urban Public Transport Modes
Authors: Dudkin Evgeniy , Abuzhvaid Husam Abbas Mohsin
Published: June 2023

Purpose: Improving the urban public transport (UPT) system to ensure its efficient operation in Iraqi cities. Choice and justification of the urban transport mode in Najaf (Iraq), which will improve safety and speed of movement of passengers. Justification of the application areas for different types of transport in Iraqi cities by optimizing and selecting modes of passenger transport based on traffic volume, passenger density and urban characteristics. Methods: Statistical processing, functional analysis, mathematical modelling, probability theory, analysis of urban passenger transport in Iraqi cities, classifying Iraqi cities by main characteristics: population density, area, level of motorization, the maximum length of the territory, analysis of passenger traffic intensity and average capacity of the rolling stock. Results: New boundaries of average passenger flow density intervals have been adjusted for groups of Iraqi cities, allowing for the selection of the type of UPT and its share of transportation for each type of rolling stock. A distribution of urban transport modes has been proposed, taking into account the characteristics of Iraqi cities according to their classification. Practical significance: The application of the developed proposals and activities allows: to justify and select the types of urban transport systems for the city of Najaf; to calculate passenger traffic on six different routes with maximum traffic for the city of Najaf; to determine the classification of rolling stock capacity series and the UPT options for Iraqi cities; to provide recommendations for the development of the transport network of Iraqi cities. The proposed distribution of urban transport modes improves public transport services and the quality of use of each mode of transport.
The Procedure for Planning the Operation of Low-Intensity Railway Lines: Logistical Aspects and Neural Network Models
Authors: Kovalev Konstantin , Novichihin Alexey
Published: June 2023

Purpose: Improving the efficiency of the line functioning based on the development of a procedure for planning the operation of low-intensity railway lines based on neural networks. Methods: Methods of analysis, synthesis, machine learning, neural network modeling have been applied. Results: Using regression multiple analysis and mathematical tools, a set of neural network models for planning the operation of a low-intensity railway line according to a set of indicators has been developed. Planning parameters have been determined, which enable the railway line operations to achieve a positive financial outcome. Practical significance: The conducted research is an effective tool for improving the planning of the work of low-intensity railway lines.
Prospective Technologies of Hazard Visualization
Authors: Kanonin Yuriy , Tihomirov Oleg , Iost Natal'ya
Published: June 2023

Purpose: To identify the most prospective technologies for visualizing potential hazards to warn workers in production, including railway transport, as well as any person in everyday life. Methods: Search and comparative analysis of information about new technologies for visualizing hazards in various areas of life to determine the possibility and expediency of their wider implementation. Results: A review and evaluation of existing methods and systems for alerting individuals to hazards, including technologies that have emerged in recent years, such as safety marker lights (BlueSpot and RedSpot, Red Line and Blue Line), GOBO projectors, Slide-mapping technology, Fogscreen, or aerosol screens, virtual or digital walls. Practical significance: The conducted assessment of the advantages and disadvantages of certain hazard visualization technologies will allow for a more reasonable choice of the most advanced systems for a particular field of activity and will contribute to their implementation in practice.
Diagnóstico e Tratamento do Neuro-Behçet: Uma Actualização Clínica
Authors: Silva Lénia , Correia João , Santos Ernestina
Published: June 2023

A doença de Behçet é uma síndrome inflamatória multissistémica recidivante, caraterizada por úlceras orais e/ou genitais recorrentes, uveítes, artrite, lesões cutâneas e envolvimento gastrointestinal e neurológico. O neuro-Behçet corresponde ao envolvimento do sistema nervoso e é uma das complicações mais graves da doença de Behçet. Ocorre em 3% a 30% dos casos e categoriza-se em doença parenquimatosa (mais frequente) ou não-parenquimatosa. A manifestação mais comum do neuro-Behçet parenquimatoso é a meningoencefalite com acometimento do tronco cerebral, sendo que os doentes se apresentam com neuropatias cranianas, encefalopatia, síndromes sensitivo-motoras, epilepsia ou mielite. A principal manifestação não-parenquimatosa é a trombose venosa cerebral. O neuro-Behçet apresenta uma evolução maioritariamente subaguda, com remissão em semanas, ou com progressão clínica, em um terço dos casos. O diagnóstico é essencialmente clínico e os exames complementares auxiliam a corroborar a suspeita, a diferenciar de diagnósticos diferenciais e a excluir complicações. A ressonância magnética cerebral permite observar lesões agudas (hipo ou isointensas em T2 e hipointensas em T1) que captam contraste, e lesões crónicas caraterizadas por pequenas lesões que não captam contraste e atrofia do tronco cerebral. Na suspeita de envolvimento não-parenquimatoso deve ser realizada venoressonância magnética/tomografia computorizada cerebral. O líquido cefalorraquidiano apresenta elevação da proteinorraquia e da pleocitose no neuro-Behçet parenquimatoso e não tem alterações no não-parenquimatoso (exceto aumento da pressão de abertura). Os surtos de doença parenquimatosa devem ser tratados com corticoterapia endovenosa em alta dose, com posterior desmame para corticoterapia oral, seguida de terapêutica biológica, habitualmente anti-TNF. O tratamento da trombose venosa cerebral é controverso, podendo consistir na associação de corticoterapia e anticoagulação.
Perception on the employment of treated sewage in concrete production
Authors: Tonetti Adriano Luiz , Imark Letícia Pauluk
Published: June 2023

Civil construction is responsible for the consumption of large amounts of water in concrete manufacturing, hydration of cementitious materials, equipment cleaning and aggregate washing. Therefore, the employment of reclaimed water in concrete production could be a relevant possibility for large-scale recycling, cost reduction and conscious use of raw materials, whose potential is currently little explored in the world. This study is aimed at understanding how civil engineers and architects see the applicability of reclaimed water, both as part of the concrete mixture and in its production process. A total of 94% of the professionals interviewed accepted the reclaimed water; however, they observed that the greatest difficulty for the commercialization of such concrete is the low acceptance of the product by consumers.
La primera generación de cineastas tunecinas y sus largometrajes de ficción como contradiscurso feminista (1976-2017)
Authors: Socías Baeza Javier
Published: June 2023

Las mujeres tunecinas tienen un estatuto jurídico casi igualitario, lo que constituye una situación excepcional en el mundo araboislámico. Ese estatuto es fruto, sobre todo, de la política de emancipación femenina promovida por el exprimer ministro y expresidente Habib Burguiba, quien se atribuyó a sí mismo el sobrenombre de “El Libertador de la Mujer”. No obstante, las cineastas tunecinas de la primera generación, integrada por Selma Baccar, Nejia Ben Mabrouk, Moufida Tlatli y Kalthoum Bornaz, construyeron un contradiscurso cinematográfico feminista que cuestionó tanto los límites de dicha emancipación como la reapropiación de la historia de las mujeres tunecinas por parte de Burguiba. Este texto es un breve estudio sobre la construcción de ese contradiscurso mediante la lectura histórica de documentos y testimonios de esas cineastas, desde la perspectiva de la historia de las mujeres y del género y del feminismo de la igualdad, de la diferencia y/o situacionista, como categorías de análisis.
Tocar el pasado
Authors: Garbayo-Maeztu Maite
Published: June 2023

Este artículo se ocupa de diseccionar y analizar las metodologías y estrategias de investigación feministas que he desplegado en mis estudios sobre las producciones de mujeres artistas en la historia del arte contemporáneo en el Estado español. Me centro específicamente en un caso de estudio: mi investigación sobre las artistas que trabajaron con los llamados nuevos medios (performance, instalación, vídeo…) durante los últimos años de la dictadura franquista y los primeros de la Transición (década de los setenta). Analizo mi aproximación a artistas como Olga L. Pijoan, Fina Miralles o Àngels Ribé. Intento explorar los silencios, las ausencias, y cómo hacerlas aparecer a través del archivo y de la historia oral, proponiendo formas de torcer y desviar los modos de hacer historia del arte en nuestro contexto. La figura de la historiadora del arte feminista aparece como un ser deseante, como un cuerpo-espacio que posibilita que pasado y presente se toquen, para poder vislumbrar las desconexiones, las conexiones, y la presencia fantasmática de lo femenino como un continuum en el arte español contemporáneo.
Feminismos em campo expandido
Authors: Simioni Ana Paula Cavalcanti , Mayayo Patricia
Published: June 2023

O presente dossiê reune textos que debatem, analisam e/ou problematizam os impactos dos feminismos no sistema/mundo das artes, notadamente em países e regiões menos estudados pela bibliografia existente. Assim, buscou-se um conjunto de reflexões sobre a recepção, circulação, reinterpretação, importância, e mesmo as fragilidades, resistências e rechaço às proposições feministas em países fora do eixo anglo-saxão. Entendemos feminismo como um campo plural e diverso, que congrega proposições e estéticas múltiplas, que variam conforme o contexto em que são produzidas e mobilizadas.
Surveys of a small population of the Endangered Black-throated Finch Poephila cincta cincta in North Queensland
Authors: Grice Anthony , Large Tamara ,   North Queensland Dry Tropics, P.O. Box 1466, Townsville QLD 4810, Australia, Kahler Christopher ,   Ecological Interpretation, 21 Humphrey Street, Townsville QLD 4810, Australia, Heading Rodney
Published: June 2023

The Endangered southern subspecies of the Black-throated Finch Poephila cincta cincta survives in two recognised ‘strongholds’: parts of the Galilee Basin and the Townsville Plains, in Queensland. Elsewhere, there are apparently smaller populations scattered north of the Tropic of Capricorn. Between November 2014 and April 2018, 15 field surveys for Black-throated Finches were conducted on Toomba Station, a cattle property west of Charters Towers, North Queensland. Black-throated Finches were detected during five of these surveys, indicating the presence of a small and possibly isolated population. They were detected on 16 of the 65 survey days over a 3.5-year period. All but two detections were within 400 m of one of two water sources, one a cattle trough and the other a small farm dam. The habitat consisted principally of open woodland dominated by Narrow-leaved Ironbark Eucalyptus crebra and other Eucalyptus and Corymbia species. Blackthroated Finches were observed attending the two water sources, foraging and resting. The largest number seen was 13. Other observations detected 1–11 birds. These numbers, along with the limited number of sites at which the species was detected despite considerable search effort, suggest that the total population of the district is very small. Small and isolated populations are likely to be vulnerable to drought, local changes in land use and stochastic factors. Given the current threats to the Blackthroated Finch in its ‘strongholds’, it is important to ascertain the status, ecology and conservation needs of any remaining small, isolated populations of this subspecies.
From Optimal Control to Optimal Transport via Stochastic Neural Networks in the Mean Field Setting
Authors: Garbelli Matteo , Di Persio Luca
Published: June 2023

In this paper we derive a unified perspective for Optimal Transport (OT) theory and Mean Field Control (MFC) theory to analyse the learning process for Neural Networks algorithms in a high-dimensional framework. We consider Mean Field Neural Networks in the context of MFC theory, specifically the mean field formulation of OT theory that allows the development of highly efficient algorithms while providing a powerful tool in the context of explainable Artificial Intelligence.
Pedestrian Safety: Drivers Stopping Behaviors at Crosswalk
Authors: NKURUNZIZA David , TAFAHOMI Rahman , IRUMVA Faraja Augustin
Published: June 2023

The safety of a pedestrian crossing may depend on infrastructure, vehicular and pedestrian traffic characteristics. This research portrays the safety challenges caused by vehicles on crosswalk in the City of Kigali. Through observing the stopping of drivers in pedestrian crossing events, the study aims to evaluate driver’s behaviors against traffic flow parameters. 10 collection sites were finally selected purposively and randomly to suit observations for data recording. A total of 10,259 crossing events were recorded within 280 hours. Statistical analysis, tests and Binary logistic regression model were used to evaluate the behaviors. Sadly,82.4% drivers violate crosswalks, endangering crossing. Motorcyclists exhibit the most aggressive behavior. Car drivers are relatively less aggressive,60% managed to brake in the events. Buses and bicycles share a negligible collective of 2%, being aggressive and would not stop. Cars are 10.389 times more likely to stop compared to bicycles. Having more vehicles in a row is safer to cross, for each unit increase on the vehicle density scale, there were 1.956 more chances that every driver would stop.13% to 21% of traffic variables predict the variance in stopping behaviors model.
Low-Cost UAV Photogrammetry and GNSS Technology for Digital Terrain Modeling: The DIACHRONIC LANDSCAPES Workshop Case
Authors: Sterpin Andrea , Medici Marco
Published: June 2023

This study examines the activities conducted at the archaeological site of Aptera in Crete, Greece. The research was part of the DIACHRONIC LANDSCAPES International Design Workshop, organized by the CAM (Center for Mediterranean Architecture), TUC (Technological University of Crete School of Architecture), and UNIFE (University of Ferrara Department of Architecture). This article outlines the methods used for data acquisition and processing on a territorial scale, which generated digital outputs necessary for the analysis and design phases of the workshop, as well as for further examination of the results. The collected data, obtained through low-cost aerial photogrammetric surveying and GNSS terrestrial coordinate detection, were integrated in a Structure from Motion workflow that led to the creation and exportation of various digital outputs, such as point clouds, DTM, DSM, orthophotos, and contour lines. An accuracy analysis was performed to evaluate the effectiveness and efficiency of the digital models compared to the implemented surveying strategies, including the Ground Control Point and Quality Check Point marker positioning strategy. The resulting digital models proved to be valuable assets for analysis and design within the workshop and provided insightful prospects for future research and territorial-scale projects.
Social Constructivist Meta-Ethnography
Authors: Soundy Andrew
Published: June 2023

Objective: The objective of this review was to establish a modified meta-ethnography framework by integrating the traditional phases with methods from social constructivist grounded theory. The modified version was required to identify methods which can ensure analytic generalisability and honour critical inquiry. Method: A narrative synthesis review was undertaken using 4 electronic databases. Articles were located that described the methods and methodologies of meta-ethnography and social constructivist grounded theory. A synthesis was undertaken which integrated the methods of social constructivist grounded theory. Results: The meta-ethnography was undertaken in 5 phases: (1) The positionality of the researcher and the area of interest identified. (2) Identifying what is relevant. (3) Reading the study and determining how studies are related. (4) The iterative process of idea generation required for theory generation. And (5) Expression of the theory, model, or process. Conclusion: The current study provides a useful tool to support the development of a substantive theory (a theory in one area) which can be used then to consider its application in other areas. This approach will help create new lines of research and aid the explanation of problems in other areas.
Pre-hospital Management of Patients with COVID-19 and the Impact on Hospitalisation
Authors: Grannec Floann , Meddeb Line , Tissot-Dupont Herve , Gentile Stephanie , Brouqui Philippe
Published: June 2023

Context. During the COVID-19 pandemic, patient care was mainly organised around the hospital. Pre-hospital care has, to our knowledge, never been evaluated. Objective: To evaluate the impact of pre-hospital pathways on hospitalisation during the last part of the pandemic. Design. This was a monocentric retrospective analysis of prospectively collected medical records. Data from patients admitted to our institute between 1 February and 7 March 2022 were analysed. Main Outcome Measure(s): The primary outcomes were defined as the number of hospitalisations, resuscitations, and deaths at the time of interview and in the subsequent 30 days. The main explanatory variables were times from onset of symptoms to care, age, gender, News2 score, comorbidities, and pre-hospital pathways and their duration. Results: Three pre-hospital pathways have been identified: a pathway in which the patient consults a general practitioner for a test (PHP1); a pathway in which the patient consulted for care (PHP2); and no pre-hospital pathway and direct admission to hospital (PHP3). Factors independently associated with outcome (hospitalisation) were being male (OR 95% CI; 2.21 [1.01–4.84], p=0,04), News2 score (OR 95% CI; 2.04 [1.65–2.51], p<0.001), obesity (OR 95% CI; 3.45 [1.48–8.09], p=0.005), D-dimers > 0.5 µg/ml (OR 95% CI; 3.45 [1.47–8.12], p=0.005), prolonged time from symptoms to hospital care (PHP duration) (OR 95% CI; 1.07 [1.01–1.14], p=0.03). All things being equal, patients with a “PHP2” pre-hospital pathway had a higher probability of hospitalisation compared to those with a “PHP3” pre-hospital pathway (OR 95% CI; 4.31 [1.48–12.55], p=0.007). Conclusions. Along with recognised risk factors such as gender, News 2 score, and obesity, the patient’s pre-hospital pathway is an important risk factor associated with hospitalisation.
Generating Robust Optimal Mixture Designs Due to Missing Observation Using a Multi-Objective Genetic Algorithm
Authors: Limmun Wanida , Chomtee Boonorm , Borkowski John J.
Published: June 2023

Missing observation is a common problem in scientific and industrial experiments, particularly in a small-scale experiment. They often present significant challenges when experiment repetition is infeasible. In this research, we propose a multi-objective genetic algorithm as a practical alternative for generating optimal mixture designs that remain robust in the face of missing observation. Our algorithm prioritizes designs that exhibit superior D-efficiency while maintaining a high minimum D-efficiency due to missing observation. The focus on D-efficiency stems from its ability to minimize the impact of missing observations on parameter estimates, ensure reliability across the experimental space, and maximize the utility of available data. We study problems with three mixture components where the experimental region is an irregularly shaped polyhedral within the simplex. Our designs have proven to be D-optimal designs, demonstrating exceptional performance in terms of D-efficiency and robustness against missing observations. We provide a well-distributed set of optimal designs derived from the Pareto front, enabling experimenters to select the most suitable design based on their priorities using the desirability function.
VLDL Biogenesis and Secretion: It Takes a Village
Authors: van Zwol Willemien , van de Sluis Bart , Ginsberg Henry , Kuivenhoven Jan Albert
Published: June 2023

The production and secretion of very-low density lipoproteins (VLDL) by hepatocytes has a direct impact on liver fat content as well as the concentration of cholesterol and triglycerides in the circulation and thus affects liver and cardiovascular health, respectively. Importantly, excess caloric intake and lack of physical activity are associated with overproduction of VLDL, hepatic steatosis, and increased levels of atherogenic lipoproteins. Cholesterol as well as triglycerides in remnant particles after VLDL lipolysis are risk factors for atherosclerotic cardiovascular disease (ASCVD) and have garnered increasing attention over the last few decades. To date, however, increased risk of ASCVD is not the only concern when considering today’s cardiometabolic patients, as they often also suffer from hepatic steatosis. This notion highlights the importance of understanding the molecular regulation of VLDL biogenesis. Fortunately, there has been a resurgence of interest in the intracellular assembly, trafficking, degradation, and secretion of VLDL by hepatocytes, that has led to many exciting new molecular insights, the topic of this review. We think that increasing our understanding of the biology of this pathway will help improve the health of the cardiometabolic patient in the long term.
Crystal Structure of the Octahedral iron(III)-Nitrate Complexes with Isomer Dimethylurea Ligands
Authors: Béres Kende Attila , Homonnay Zoltán , Bereczki Laura , Dürvanger Zsolt , Petrusevski Vladimir , Farkas Attila , Kótai László
Published: June 2023

Three octahedral iron(III) nitrate complexes with dimethylated urea ligand isomers, [hexakis(N,N’-dimethylurea-O)iron(III)] nitrate (compound 1), trans-[diaquatetrakis(N,N-dimethylurea-O)iron(III)] nitrate (compound 2) and [hexakis(N,N-dimethylurea-O)iron(III)] nitrate trihydrate (compound 3) were prepared and characterized with single crystal X-ray diffraction, IR, Raman and UV-VIS methods. In compounds 1 and 3, six dimethylurea ligands coordinate to the central FeIII ion via the oxygen in octahedral geometry and the ligands are arranged in a propeller-like manner, dividing the complex cations into two sides. In compound 1, the dimethylurea propellers screw in the opposite direction on the two sides of the complex and in compound 3, they are arranged with the same handedness on the two sides. The complexes have helical chirality. The two sides of the complex cations differ not only in the rotation direction of the ligands but also in the hydrogen bond formation. On one side of the complex cation, the ligands form intermolecular hydrogen bonds only with the crystal waters, meanwhile on the other side of the complex, the ligands form hydrogen bonds only with the nitrate ions. In compound 2, [Fe(N,N-dimethylurea)4(H2O)2]3+ cations form layers that are separated by interconnected NO3- ions forming a hydrogen bonding system and connecting the complex cations A-s and B-s. The three crystallographically different nitrate ions each form four hydrogen bonds in a way that they have one bidentate O atom and two monodentate O atoms, however, the anions differ in their hydrogen bonding. The spectroscopic characteristics of compound 2 were determined by IR measurements on the deuterated compound 2 as well.
Does Efficiency Matter? A Study on Factors Affecting the Technical Efficiency of Betel Nut Producers in Assam
Authors: Borah Durlove , Buragohain Pranjal Protim , Saikia Jitu
Published: June 2023

Purpose- Betel nut (Areca catechu) is one of the major plantation crops grown in Assam. However, due to inefficiency in production, the productivity of betel nuts in the state is very low. Therefore, this study attempted to measure the level of technical efficiency and the factors affecting the technical inefficiency of betel nut growers in the Nagaon district of Assam.Design/methodology/approach – Primary data were collected from 240 households in the Nagaon district of Assam. Based on the Cobb-Douglas Production function for betel nut growers, the present study uses stochastic frontier analysis to estimate the production frontier and examine the effects of exogenous variables on farm-level technical inefficiency. Findings - The findings of the study reveal that, on average, 85 per cent of betel nut growers are technically efficient in the study area. Moreover, experience in betel nut plantations and gender have a significantly negative effect on technical inefficiency. In contrast, the age of the grower had a positive and significant effect on the technical inefficiency of betel nut cultivation. The findings suggest the availability of space for an increase in the productivity of betel nut plantations in the study area and scope for increasing the level of output through technical efficiency without raising inputs.Originality/Value: This study contribute to the estimation of the technical efficiency of betel nut growers and examines the factors responsible for technical inefficiency.The dataset is original and was especially collected for the present study.
Biocontrol using Torulaspora delbrueckii in Sequential Fermentation: New Insights into Low Sulfites Verdicchio Wines
Authors: Canonico Laura , Agarbati Alice , Galli Edoardo , Comitini Francesca , Ciani Maurizio
Published: June 2023

Torulaspora delbrueckii showed renewed interest in recent years in the fermentation of wine, for its biotechnological potential linked to the ability to enhance flavor and aroma and it probably is the non-Saccharomyces yeast currently widely used in winemaking. On the base of this, sequential fermentations with a selected native strain of T. delbrueckii (DiSVA 130) and low sulfite native strain of Saccharomyces cerevisiae (DiSVA 709) were carried out to establish their contribution in biocontrol and aroma profile. A first set trials, carried out in winery, were set up to establish the effect of the sulfur dioxide addition on pure and T. debrueckii/S. cerevisiae sequential fermentations. A second set of sequential fermentations without SO2 addition were conducted in the same conditions, to evaluate the biocontrol and aromatic effectiveness of the T. delbrueckii native strain and a commercial one. The effective biocontrol action of native T. delbrueckii inoculated in sequential fermentation was shown, indeed without SO2 addition the presence of native T. delbrueckii revealed an effective fungistatic action in the first two days of fermentation. Moreover, the native T. delbrueckii strain seems to have fermentative performances comparable to those of T. delbrueckii commercial strain showing a more evident biocontrol action (wild yeasts reduced by c.a. 1 Log at 2nd day) and its presence did not negatively affect S. cerevisiae fermentation activity. Finally, the combination of both native and commercial T. delbrueckii/S. cerevisiae trials led distinctive aromatic profile of wines with a significant enhancement of isoamyl acetate, phenyl ethyl acetate, supported by positive appreciations, from the tasters, for ripe and tropical fruits, citrus and balance. The whole results indicate that the proposed strain could be a potential biocontrol tool toward wild yeasts in the first phase of fermentation also contributing to improve and differentiate the final aroma wine.
Comparative Analysis of the Impact of Two Common Residue Burning Parameters on Urban Air Quality Indicators
Authors: Du Jia , Li Dianjia , Song Kaishan , Zheng Zhi , Wang Yan
Published: June 2023

Crop residue burning produces a lot of polluting gases and fine particles, endangering human health, damaging soil structure, and causing fire accidents. In addition to the impact of residue burning on the local environment, pollutants can spread with the wind to more distant areas and impact the air quality of surrounding areas, especially cities. Nevertheless, a comparative analysis of the impact of two common residue burning parameters, the number of residue fire points and residue burned area, on urban air quality indicators has not been reported. In this study, the correlation between these two different residue burning parameters on air quality in Daqing City was investigated comparatively using the Visible Infrared Imaging Radiometer Suite (VIIRS) fire point product, the Moderate-resolution Imaging Spectroradiometer (MODIS) burned area product, and buffer zone analysis. The association between MODIS burned area products and air quality index (AQI) was found to be around 0.8, with a maximum of 0.816 at a buffer zone radius of 50 km. Meanwhile, it was found that the correlation between the number of residue fire points extracted from the VIIRS active fire products and air quality was above 0.6, again with a maximum of 0.745 at a buffer radius of 50 km. Within other levels of buffer zones, the correlation between residue burned area and AQI was consistently higher than that between residue fire points and AQI. By comparing the correlation between VIIRS fire points, MODIS burned area, and AQI with the concentration of each pollutant, we found that the correlation between residue burned area and AQI and the concentration of each pollutant is higher. MODIS burned area monitoring, on the other hand, detects changes in the time series of images taken by satellite at two transit moments to obtain the new burned area and cumulative burned area during this period, allowing the monitoring of fire traces caused by fire points at non-transit moments. From analyzing the correlation between residue fire points, residue burned area, and the concentration of each pollutant (PM2.5, PM10, CO, NO2, SO2, O3), we found significant correlations between residue burning and PM2.5, PM10, CO, and NO2 concentrations, with the highest correlation (R2) of 0.81 for PM2.5. Moreover, the correlation between residue burned area and PM2.5, PM10, CO, and NO2 concentrations was significantly higher than that between the number of residue fire points and their concentrations.
Illuminating Shadows: Decoding Three Mythological Veil of Mindanao's Cultural Tapestry
Authors: Eslit Edgar R.
Published: June 2023

This research article aims to uncover the mysteries surrounding Mindanao’s cultural heritage by examining its myths, symbols, and philosophies. Through a multidisciplinary approach, this paper reveals the deeper meanings behind Mindanao’s mythology and encourages critical thinking and a deeper understanding of the connections between myth, culture, and identity.
Node Oligo-Recurrence in Prostate Cancer: A Challenge
Authors: Zapatero Almudena , Conde Moreno Antonio Jose , Barrado Los Arcos Marta , Aldave Diego
Published: June 2023

Within the oligometastatic state, oligo-recurrent lymph node disease in prostate cancer represents an interesting clinical entity characterized by a relatively indolent biology that makes it unique: it can be treated radically, and its treatment is usually associated with a long period of control and excellent survival. Additionally it is an emergent situation that we are facing more frequently, mainly due to: a) the incorporation into clinical practice of the PSMA PET that provides strikingly increase superior images in comparison to conventional imaging, with higher sensitivity and specificity; b) the higher detection rates of bone and node disease with extremely low levels of PSA; and c) the availability of high-precision technology in radiotherapy treatments with the incorporation of stereotaxic body radiotherapy (SBRT) or stereotaxic ablative radiotherapy (SABR) technology that allows the safe administration of high doses of radiation in a very limited number of fractions with low toxicity and excellent tolerance. This approach of new image-guided patient management is compelling for doctors and patients since it can potentially contribute to improve the clinical outcome. In this work we discuss the available evidence, areas of debate, and potential future directions concerning the utilization of new imaging guided SBRT for the treatment of nodal recurrence in prostate cancer.
The Betel Nut Intervention Trial (BENIT). A Randomized Clinical Trial for Areca Nut and Betel Quid Cessation: Primary Outcomes
Authors: Herzog Thaddeus A , Wilkens Lynne R , Badowski Grazyna , Mendez Ana Joy Pacilan , Franke Adrian A , Pokhrel Pallav , Chennaux Jade S.N. , Tenorio Lynnette F , Sotto Patrick P , Kawamoto Crissy T , Paulino Yvette C
Published: June 2023

Background: Areca nut and betel quid (ANBQ) chewing is a widespread carcinogenic habit. The BENIT (ClinicalTrials.gov - NCT02942745) is the first known randomized trial designed for ANBQ chewers. Methods: We compared intensive behavioral treatment intervention condition (IC) with control condition (CC) in the BENIT and included a 5-stage early stopping rule. We report the primary analysis at stage 3. English literate adults in Guam and Saipan who self-identified as ANBQ chewers with tobacco were enrolled between August 2016 and August 2020. IC participants (n=88) received five in-person sessions over 22 days and a brochure containing quitting advice. CC participants (n=88) received only the brochure. Participants were assessed at baseline and day-22 follow-up. Self-reported chewing status at day-22 was determined by a composite of two survey items with disparate wording and response options for cross-verification. Results: Cessation rates were 38.6% (IC) and 9.1% (CC). Proportional hazards regression revealed a p=0.0058, which met the Stage 3 criteria for significance and an estimated reduction in ANBQ chewing for IC compared to the CC of 71% (95% CI: 41%-88%). Conclusion: Robust self-reported intervention effects at day-22 suggests that intensive cessation programs such as BENIT should be further developed and implemented on a larger scale.
Preparation and Characterization of Light-Colored Polyimide Nanocomposite Films Derived from Fluoro- Containing Semi-Alicyclic Polyimide Matrix and Colloidal Silica with Enhanced High-Temperature Dimensionally Stability
Authors: He Zhibin , Ren Xi , Wang Zhenzhong , Pan Zhen , Qi Yuexin , Han Shujun , Yu Haifeng , Liu Jingang
Published: June 2023

Light-colored and transparent polyimide (PI) films with good high-temperature dimensional stability are highly desired for advanced optoelectronic applications. However, in practice, the simultaneous achievement of good optical and thermal properties in one PI film is usually difficult due to the inter-conflicting molecular design for the polymers. In the present work, a series of PI-SiO2 nanocomposite films (ABTFCPI) were developed based on the PI matrix derived from hydrogenated pyromellitic anhydride (HPMDA) and an aromatic diamine containing benzanilide and trifluoromethyl substituents in the structure, 2,2'-bis(trifluoromethyl)-4,4'-bis[4-(4-aminobenzamide)]biphenyl (ABTFMB). The inorganic SiO2 fillers were incorporated into the nanocomposite films with the form of colloidal nanoparticles dispersed in the good solvent of N,N-dimethylacetamide (DMAc) for the PI matrix. The derived ABTFCPI nanocomposite films showed good film-forming ability, flexible and tough nature, good optical transparency, and good thermal properties with the loading amounts of SiO2 up to 30 wt% in the system. The ABTFCPI-30 film with the SiO2 content of 30 wt% in the film showed the optical transmittance of 79.6% at the wavelength of 400 nm (T400) with a thickness of 25 μm, the yellow index (b*) of 2.15, and the 5% weight loss temperatures (T5%) of 491 oC, which are all comparable to those the pristine ABTFCPI-0 matrix without filler (T400=81.8%; b*=1.77; T5%=492 oC). Meanwhile, the ABTFCPI-30 film exhibited obviously enhanced high-temperature dimensional stability with the linear coefficients of thermal expansion (CTE) of 25.4×10-6/K in the temperature range of 50 to 250 oC, which is much lower than that of the AMTFCPI-0 film (CTE=32.7×10-6/K).
The Normalizer of a Lie Group. Applications and Challenges
Authors: Ayala Victor , Da Silva Adriano , Torreblanca María
Published: June 2023

Let G be a connected Lie group with Lie algebra g. This review is devoted to studying the fundamental dynamic properties of elements in the normalizer NG of G. Through an algebraic characterization of NG we analyze the different dynamics inside the normalizer. NG contains the well-known left-invariant vector fields and the linear and affine vector fields on G. In any case, we show the shape of the solutions of these ordinary differential equations on G. We give examples in low-dimensional Lie groups. It is worth saying that these dynamics generate the linear and
bilinear control systems on Euclidean spaces and the invariant and linear control systems on Lie groups. Moreover, the Jouan Equivalence Theorem shows how to extend this theory to control systems on manifolds.