bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory role of cytokines on etiology of depression in animal models: their biological mechanisms and clinical implication with physical exercise
Authors: Park Hyun Jung , Rhie Sung Ja , Shim Insop
Published: December 2022

It has been known that chronic psychological or physical stress elicits depressive behaviors (learned helplessness, anhedonia, anxiety, etc.) and also activates to release proinflammatory cytokines in the brain. Especially, postmenopausal women under stress condition exacerbates neuroimmune systems and mood disorder. Repeated restraint stress in the ovariectomized female rats poses an immune challenge which was capable of inducing depressive-like behaviors, promoting exaggerated corticosterone responses and changing the proinflammatory cytokine expression such as interleukin (IL)-1β in the brain. Also, anti-inflammatory cytokines including IL-4 are known to regulate inflammation caused by immune response or stress challenge. Furthermore, some studies reported that physical activity can reduce stress hormones and improve personal immunity. Physical exercise has been shown to be associated with decreased symptoms of depression and anxiety, and with improved physical health, immunological function, and psychological well-being. This paper aims to discuss an overview of how stress shapes neuroimmune response and diverse roles of cytokines in animals models, acting on depressive-like behavioral changes; some beneficial aspects of exercise on stress-related disorders are addressed.
Challenges Facing the Development and Market Introduction of Hardwood Cross-Laminated Timbers
Authors: Hassler Curt , McNeel Joseph F. , Denes Levente , Norris Jonathan , Bencsik Balasz
Published: December 2022

The interest in softwood-based cross-laminated timber (CLT) production has in turn generated a great deal of interest in producing CLT from hardwood species. This prospect of a new market for hardwood lumber is a significant driver behind efforts to gain certification of hardwoods within American Panel Association (APA) PRG 320, Standard for Performance-Rated Cross-Laminated Timber. However, a number of challenges present significant hurdles for gaining acceptance of hardwoods in CLT manufacturing. These include differences in how softwoods and hardwoods are produced and marketed (e.g., structural lumber markets [softwoods] vs. appearance-grade markets [hardwoods]), lumber grading differences, available sizes of hardwood lumber, drying differences between hardwoods and softwoods, and gluing particularities with hardwoods. This paper identifies the various issues involved with introducing hardwoods into a softwood-dominated market and what it will take to be competitive within the overall CLT market.
No more deadlines? Tracing transcarceral time in ‘critical’ social work education
Authors: Poole Jennifer M. , Zerafa Samantha
Published: December 2022

Colonial critical social work education is a strange place. It professes a goal of social justice but subscribes to an often-unconscious compliance with what has been named as ‘colonial’ or ‘white time’. White time sets and enforces limits for the completion of courses, programmes and assignments. Such colonial chrononormativity also sets and enforces what counts as and in history. In this article, we question this time compliance, tracing literature on critical temporalities that take up, for example, crip, queer and pandemic time. Drawing on abolitionist work, we then outline how colonial time may also be transcarceral, that is, confining and punishing, especially when we commit time-crime and ‘miss’ a deadline. Indeed, by delving into the little-known but violent history of deadlines, we hope to encourage more refusals of transcarceral time, as well as deliberate discussions that create space for a range of temporalities in our classrooms and beyond.
Ethnocultural long-term care homes in Canada: a place for cultural inheritance and community building
Authors: Niki Izumi
Published: December 2022

This article discusses the overlooked role of recreation programmes in the ethnocultural and cultural-specific long-term care home from my standpoint as a recreation worker. First, the policy during the pandemic that prohibited visits by family members and volunteers revealed that they are important informal caregivers to fill in for the limitations of workers. Second, recreational programmes can also be considered as a practice of cultural inheritance: staff and volunteers learn their history and reconstruct them as collective memory. Third, the interaction between residents, volunteers, families and workers generates a sense of belonging to the ethnic community. Therefore, it can be considered a practice of community building for minority ethnic groups. By presenting the significant role of recreation workers in a long-term care home, I aim to question the meaning and value of care work in long-term care facilities.
Optical memory effect of excised cataractous human crystalline lenses
Authors: Paniagua-Diaz Alba M. , Simón Dulce M. , Martínez Carmen , Moreno Elena , Rodríguez-Ródenas Alba , Yago Inés , Marín Jose María , Artal Pablo
Published: December 2022

Cataracts increase the amount of scattered light in the crystalline lens producing low-contrast retinal images and causing vision impairment. The Optical Memory Effect is a wave correlation of coherent fields, which can enable imaging through scattering media. In this work, we characterize the scattering properties of excised human crystalline lenses by measuring their optical memory effect and other objective scattering parameters, finding the relationship between them. This work has the potential to help fundus imaging techniques through cataracts as well as the non-invasive correction of vision through cataracts.
Far field energy distribution control using a coherent beam combining femtosecond digital laser
Authors: Fsaifes Ihsan , Ranély-Vergé-Dépré Claude-Alban , Veinhard Matthieu , Bellanger Séverine , Chanteloup Jean-Christophe
Published: December 2022

We report on far field energy distribution control using a coherent beam combining femtosecond digital laser employing 61 tiled channels. Each channel is considered as an individual pixel where amplitude and phase are controlled independently. Applying a phase difference between neighboring fibers or neighboring fiber-lines gives high agility for far field energy distribution and paves the way for deeper exploration of phase patterns as a tool to further improve tiled-aperture CBC laser efficiency and far field shaping on demand.
Information security scheme using deep learning-assisted single-pixel imaging and orthogonal coding
Authors: Wang Xiaogang , Lin Shanshan , Xue Jidong , Xu Biju , Chen Junlang
Published: December 2022

Providing secure and efficient transmission for multiple optical images has been an important issue in the field of information security. Here we present a hybrid image compression, encryption and reconstruction scheme based on deep learning-assisted single-pixel imaging (SPI) and orthogonal coding. In the optical SPI-based encryption, two-dimensional images are encrypted into one-dimensional bucket signals, which will be further compressed by a binarization operation. By overlaying orthogonal coding on the compressed signals, we obtain the ciphertext that allows multiple users to access with the same privileges. The ciphertext can be decoded back to the binarized bucket signals with the help of orthogonal keys. To enhance reconstruction efficiency and quality, a deep learning framework based on DenseNet is employed to retrieve the original optical images. Numerical and experimental results have been presented to verify the feasibility and effectiveness of the proposed scheme.
Reflection mode optical trapping using polarization symmetry breaking from tilted double nanoholes
Authors: Khosravi Behnam , Gordon Reuven
Published: December 2022

We demonstrate reflection geometry optical trapping using double nanoholes in a metal film. Symmetry breaking of the double nanohole allows for selecting the scattered trapping laser light of orthogonal polarization to the incident beam. This orthogonal polarization light shows a few percent increase when the nanoparticle (e.g., a 20 nm polystyrene particle, or protein bovine serum albumin) is trapped. The reflection geometry simplifies the optical setup and frees up one side of the trap, which has great potential for adding microfluidics to the other side or working with opaque or highly scattering samples.
Broad-angle coherent perfect absorption-lasing and super-collimation in two-dimensional non-Hermitian photonic crystals
Authors: Xu Changqing , Ahmed Waqas Waseem , Wu Ying
Published: December 2022

Coherent perfect absorption-lasing (CPAL) and collimation have been intensively studied for normal and small angle wave incidence. Here, we report a two-dimensional non-Hermitian photonic crystal for broad-angle CPAL and super-collimation. The synergy of a nonsymmorphic glide symmetry of the lattice, gain-loss modulation and an optimization of unit cell induces a parity-time phase transition in the band structure along the Brillouin zone boundary. The transition points, i.e., the exceptional points, form a slab-like contour, with nearly zero dispersion in both real and imaginary parts of the band structure. Such dispersionless band structure significantly enhances the range of incident angle for CPAL and collimation.
The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions
Authors: Brown Rebecca E. , Su Xiaofeng A. , Fair Stacey , Wu Katherine , Verra Lauren , Jong Robyn , Andrykovich Kristin , Freudenreich Catherine H.
Published: December 2022

Expansion of structure-forming CAG/CTG repetitive sequences is the cause of several neurodegenerative disorders and deletion of repeats is a potential therapeutic strategy. Transcription-associated mechanisms are known to cause CAG repeat instability. In this study, we discovered that Thp2, an RNA export factor and member of the THO (suppressors of transcriptional defects of hpr1Δ by overexpression) complex, and Trf4, a key component of the TRAMP (Trf4/5-Air1/2-Mtr4 polyadenylation) complex involved in nuclear RNA polyadenylation and degradation, are necessary to prevent CAG fragility and repeat contractions in a Saccharomyces cerevisiae model system. Depletion of both Thp2 and Trf4 proteins causes a highly synergistic increase in CAG repeat fragility, indicating a complementary role of the THO and TRAMP complexes in preventing genome instability. Loss of either Thp2 or Trf4 causes an increase in RNA polymerase stalling at the CAG repeats and other genomic loci, as well as genome-wide transcription-replication conflicts (TRCs), implicating TRCs as a cause of CAG fragility and instability in their absence. Analysis of the effect of RNase H1 overexpression on CAG fragility, RNAPII stalling, and TRCs suggests that RNAPII stalling with associated R-loops are the main cause of CAG fragility in the thp2Δ mutants. In contrast, CAG fragility and TRCs in the trf4Δ mutant can be compensated for by RPA overexpression, suggesting that excess unprocessed RNA in TRAMP4 mutants leads to reduced RPA availability and high levels of TRCs. Our results show the importance of RNA surveillance pathways in preventing RNAPII stalling, TRCs, and DNA breaks, and show that RNA export and RNA decay factors work collaboratively to maintain genome stability.
Seasonal timing on a cyclical Earth: Towards a theoretical framework for the evolution of phenology
Authors: Park John S. , Post Eric
Published: December 2022

Phenology refers to the seasonal timing patterns commonly exhibited by life on Earth, from blooming flowers to breeding birds to human agriculture. Climate change is altering abiotic seasonality (e.g., longer summers) and in turn, phenological patterns contained within. However, how phenology should evolve is still an unsolved problem. This problem lies at the crux of predicting future phenological changes that will likely have substantial ecosystem consequences, and more fundamentally, of understanding an undeniably global phenomenon. Most studies have associated proximate environmental variables with phenological responses in case-specific ways, making it difficult to contextualize observations within a general evolutionary framework. We outline the complex but universal ways in which seasonal timing maps onto evolutionary fitness. We borrow lessons from life history theory and evolutionary demography that have benefited from a first principles-based theoretical scaffold. Lastly, we identify key questions for theorists and empiricists to help advance our general understanding of phenology.
Prospective pilot study on the predictive significance of plasma miR-30b-5p through the study of echocardiographic modifications in Cavalier King Charles Spaniels affected by different stages of myxomatous mitral valve disease: The PRIME study
Authors: Ghilardi Sara , Lecchi Cristina , Bagardi Mara , Romito Giovanni , Colombo Fabio M. , Polli Michele , Franco Celeste , Brambilla Paola G.
Published: December 2022

Specific microRNAs expressions may accurately characterize different stages of canine myxomatous mitral valve disease. This preliminary pilot study aimed to (1) describe the clinical and echocardiographic parameters of Cavalier King Charles Spaniels affected by myxomatous mitral valve disease at different American College of Veterinary Internal Medicine (ACVIM) stages (B1, B2 and C) and healthy control group (ACVIM A), comparing the parameters collected during the first examination (T0) and the end of the follow-up (T1); (2) assess the association between the values of echocardiographic parameters at T1 and the expression profile of miR-30b-5p at T0. Thirty-five Cavalier King Charles Spaniels (median age 4.29 years and median weight 9 Kg) in different ACVIM stages were included (7 A, 19 B1, 6 B2 and 3 C). Inverse probability weighting analysis was performed to estimate the association of the exposure variable (miR-30b-5p) with the outcome variables (clinical and echocardiographic variables). Time was included as variable. The results pointed out that high levels of plasma miR-30b-5p corresponded to lower values of left ventricular end-diastolic diameter normalized for body weight, end-diastolic and end-systolic volumes indexed for body weight, and left atrium-to aortic root ratio. Hence, higher miR-30b-5p expressions were associated with milder forms of mitral valve disease in our study population. In contrast, the results obtained for the intensity of heart murmur, the mitral regurgitation severity, and the Mitral INsufficiency Echocardiographic score) were not statistically significant. A relationship between high abundance of miR-30b-5p and myxomatous mitral valve disease that appear echocardiographically more stable over time has been demonstrated. In conclusion, Cavalier King Charles Spaniels affected by myxomatous mitral valve disease that at the first cardiologic evaluation showed an upregulation of miR-30b-5p are expected to experience lesser variations on their echocardiographic examination between T0 and T1.
Vitamin D knowledge and sun exposure practices among Sri Lankan healthcare undergraduates
Authors: Liyanage Guwani , Jayathunga Sanjana , Amarasekara Thamara
Published: December 2022

Introduction

Although overexposure to ultraviolet radiation may lead to skin cancer, inadequate exposure results in vitamin D deficiency (VDD). We explored vitamin D-related knowledge and sun exposure practices among Sri Lankan healthcare undergraduates.

Methods

The sampling frame consisted of medical and allied health undergraduates in a single centre. A newly developed, pre-piloted, self-administered questionnaire collected data on vitamin D knowledge, sun avoidance behaviour and outdoor time. Univariate and multivariate logistic regression analysis examined the factors related to outdoor time.

Results

A total of 482 were included in the analysis. The mean (SD) vitamin D knowledge score (0–100% scale) was 31.3% (18%). Only 17.8% scored ≥50% for knowledge. At least one sun avoidance measure was used by 59.3% of the undergraduates. A lower knowledge score was observed with a higher number of sun-avoidance behaviour (mean difference 0.84, p = 0.03). The majority (66%) spent outdoors <30 minutes per day between 9 am-3 pm. The odds of having low outdoor time were 1.6 higher for the female sex (OR:1.61, 95%CI:1.039, 2.492, p<0.001) and studying in the final year (OR:1.63, 95%CI:1.020, 2.602, p = 0.04). Medical students had a higher likelihood of low outdoor time (OR:0.55, 95%CI: 0.361, 0.835, p = 0.005).

Conclusions

The healthcare undergraduates had low vitamin D knowledge and outdoor time while having increased sun avoidance. Gender, course of study, and academic year appeared to affect outdoor time. Support and guidance should improve knowledge and sun exposure habits that suit academic work and lifestyle in this population. Also, universities can actively promote positive sun exposure by organizing outdoor events.
Procalcitonin decrease predicts survival and recovery from dialysis at 28 days in patients with sepsis-induced acute kidney injury receiving continuous renal replacement therapy
Authors: Kim Il Young , Kim Suji , Ye Byung Min , Kim Min Jeong , Kim Seo Rin , Lee Dong Won , Lee Soo Bong
Published: December 2022

Procalcitonin (PCT) is a biomarker for diagnosing infections and guiding antibiotic therapy. In this study, we investigated whether PCT can predict survival and recovery at 28 days in critically ill patients with sepsis-induced acute kidney injury (SIAKI) receiving continuous renal replacement therapy (CRRT). We examined 649 patients with SIAKI who underwent CRRT in our intensive care unit. In a multivariable Cox regression analysis, a single PCT level at CRRT initiation was not associated with survival in all patients. However, the higher % PCT decrease over 72 hours after CRRT initiation was independently associated with the higher chance of 28-day survival (per 10% decrease, hazard ratio [HR] for mortality: 0.87, 95% confidence interval [CI]: 0.85–0.89; P < 0.001). Among the survivors, the % PCT decrease over 72 hours after CRRT initiation, not a single PCT level at CRRT initiation, was independently associated with recovery from dialysis (per 10% decrease, HR for renal recovery: 1.28, 95% CI:1.21–1.36; P < 0.001). This study demonstrated that the higher % PCT decrease was independently associated with the higher chance of survival and recovery from dialysis at 28 days in critically ill patients with SIAKI receiving CRRT. Thus, a decrease in the PCT level, not a single PCT level at CRRT initiation, could be a valuable tool for predicting prognosis in these patients.
Challenges in evaluating the accuracy of AI-containing digital triage systems: A systematic review
Authors: Ilicki Jonathan
Published: December 2022

Introduction

Patient-operated digital triage systems with AI components are becoming increasingly common. However, previous reviews have found a limited amount of research on such systems’ accuracy. This systematic review of the literature aimed to identify the main challenges in determining the accuracy of patient-operated digital AI-based triage systems.

Methods

A systematic review was designed and conducted in accordance with PRISMA guidelines in October 2021 using PubMed, Scopus and Web of Science. Articles were included if they assessed the accuracy of a patient-operated digital triage system that had an AI-component and could triage a general primary care population. Limitations and other pertinent data were extracted, synthesized and analysed. Risk of bias was not analysed as this review studied the included articles’ limitations (rather than results). Results were synthesized qualitatively using a thematic analysis.

Results

The search generated 76 articles and following exclusion 8 articles (6 primary articles and 2 reviews) were included in the analysis. Articles’ limitations were synthesized into three groups: epistemological, ontological and methodological limitations. Limitations varied with regards to intractability and the level to which they can be addressed through methodological choices. Certain methodological limitations related to testing triage systems using vignettes can be addressed through methodological adjustments, whereas epistemological and ontological limitations require that readers of such studies appraise the studies with limitations in mind.

Discussion

The reviewed literature highlights recurring limitations and challenges in studying the accuracy of patient-operated digital triage systems with AI components. Some of these challenges can be addressed through methodology whereas others are intrinsic to the area of inquiry and involve unavoidable trade-offs. Future studies should take these limitations in consideration in order to better address the current knowledge gaps in the literature.
Extended regimen of a levonorgestrel/ethinyl estradiol transdermal delivery system: Predicted serum hormone levels using a population pharmacokinetic model
Authors: Stanczyk Frank Z. , Archer David F. , Lohmer Lauren R. L. , Pirone Jason , Previtera Michelle , Korner Paul
Published: December 2022

Objective

This study employed population pharmacokinetic (popPK) models to predict levonorgestrel (LNG) and ethinyl estradiol (EE) exposure after dosing with the transdermal contraceptive TWIRLA® (LNG/EE TDS) as a 12-week extended regimen in a healthy female population.

Methods

PopPK models were developed using data from a previously published phase 1, open-label, randomized clinical trial, ATI-CL14 (NCT01243580), in 36 healthy individuals. Models used cycle 2 data from 18 individuals who received the LNG/EE TDS, delivering LNG 120 μg/day and EE 30 μg/day, followed by a 1-week TDS-free period. Noncompartmental PK analyses were performed on simulated concentration–time profiles of 12 consecutive weeks of LNG/EE TDS use.

Results

The simulated concentration–time profiles and PK parameters for the simulated extended regimen indicated that predicted LNG and EE exposures at week 12 were similar to week 3 (predicted geometric mean EE area under the concentration-time curve from time 0 to 168 h [AUC0-168] on week 3 was 0.2% lower than week 12 and LNG AUC0-168 on week 3 was 0.9% lower than week 12), suggesting both were at steady state by week 3. Therefore, no notable accumulation beyond that at week 3 is predicted for LNG and EE following a 12-week extended regimen. The results are supported by the accumulation ratios based on maximum concentration and the area under the curve being similar at weeks 3 and 12 for LNG and EE.

Conclusion

These results indicate that a 12-week extended LNG/EE regimen would provide similar systemic hormonal exposure as that seen by week 3 in a standard 28-day regimen, without further hormonal accumulation. The data support the safe use of a non-daily, low-dose hormonal contraceptive in an extended regimen but should be confirmed in a clinical PK study.
Tobacco mosaic virus movement protein complements a Potato spindle tuber viroid RNA mutant impaired for mesophyll entry but not mutants unable to enter the phloem
Authors: Wu Jian , Bisaro David M.
Published: December 2022

Tobacco mosaic virus movement protein (TMV MP) is essential for virus spread between cells. To accomplish its task, TMV MP binds viral RNA, interacts with components of the cytoskeleton, and increases the size exclusion limit (SEL) of plasmodesmata. Plasmodesmata are gated intercellular channels that allow passage of small molecules and macromolecules, including RNA and protein, between plant cells. Moreover, plasmodesmata are diverse and those connecting different cell types appear to have unique mechanisms to regulate macromolecular trafficking, which likely contributes to the establishment of distinct cell boundaries. Consequently, TMV MP might be competent to mediate RNA transport through some but not all plasmodesmal gates. Due to a lack of viral mutants defective for movement between specific cell types, the ability of TMV MP in this regard is incompletely understood. In contrast, a number of trafficking impaired Potato spindle tuber viroid (PSTVd) mutants have been identified. PSTVd is a systemically infectious non-coding RNA that nevertheless can perform all functions required for replication as well as cell-to-cell and systemic spread. Previous studies have shown that PSTVd employs different structure and sequence elements to move between diverse cell types in host plants, and mutants defective for transport between specific cell types have been identified. Therefore, PSTVd may serve as a tool to analyze the functions of MPs of viral and cellular origin. To probe the RNA transport activity of TMV MP, transgenic plants expressing the protein were inoculated with PSTVd mutants. Remarkably, TMV MP complemented a PSTVd mutant defective for mesophyll entry but could not support two mutants impaired for phloem entry, suggesting it fails to productively interface with plasmodesmata at the phloem boundary and that additional viral and host factors may be required. Consistent with this idea, TMV co-infection, but not the combination of MP and coat protein (CP) expression, was able to complement one of the phloem entry mutants. These observations suggest that phloem loading is a critical impediment to establishing systemic infection that could involve the entire ensemble of TMV proteins. They also demonstrate a novel strategy for analysis of MPs.
The autosomamediality of neurodivergent folks’ Facebook pages
Authors: Meads Threasa
Published: December 2022

This article employs life narrative scholarship to examine four neurodivergent (ND) folks’ public Facebook (FB) pages that are making important contributions to the growing representation of ND culture in online spaces and social media. It argues that the participatory, networked, digital, online space of FB facilitates autobiographical acts at the intersection of automedia and autosomatography, where the latter finds its most realized form, and where these multimodal, connected, dynamic manifestations of disabled lives are best defined by an elision of the two terms (automedia and autosomatography): autosomamedia.
Othering the ‘bag-lady’: Examining stereotypes of vulnerable and homeless women in popular culture
Authors: Smith Sue , Coghlan Jo
Published: December 2022

To protect their membership rights to social resources, services and benefits, Australian citizens constantly renegotiate and reconceptualize sociocultural and political parameters around who belongs as a rights-worthy member of their society. Popular culture has the potential to shape the social, cultural and political attitudes that underpin these considerations. Popular culture mediums such as film and television are visual and narrative devices that posit binaries such as good/bad, men/women, citizen/non-citizen and so on. In particular, the binary of good/bad acts as a discourse through which audiences develop an understanding of what actions and behaviours are considered socially and culturally acceptable, and what actions and behaviours are not. This article seeks to broaden understandings of popular culture’s potential to influence how a society construes its social strictures around who is a member of the hegemonic group and who is the ‘other’. It examines depictions of poor, vulnerable and homeless women characters in film that frame them as the monstrous ‘other’ and argues that these representations negatively impact the visibility of real women who are poor, vulnerable and homeless in Australia, within spaces of sociopolitical discourse. The ongoing repercussions of which, it is contended, are that the needs of this cohort are less visible to the governments and policymakers who are tasked with protecting them.
Sons, husbands, brothers: The Gothic worlds of Thai men in the films of Kongkiat Khomsiri
Authors: Ancuta Katarzyna
Published: December 2022

Gothic has long been theorized as the domain of the feminine, the queer or the ‘soft masculine’, and most discussions of Gothic masculinity propose to see it in terms of a split of the masculine subject at the level of rationality and sexuality. This article examines the construction of Gothic masculinities in the films of the Thai director Kongkiat Khomsiri in the context of the Thai gender system and Thai heroic masculine ideologies their protagonists embody. While Thai horror films abound in depictions of feminine evil, interestingly the Gothic cinescapes of Khomsiri are the domain of tough masculine men. The article discusses the director’s first three features: , , and The , bringing into focus the films’ portrayals of their working-class underdog heroes and their ‘hard’ masculinity. The discussion also highlights the visual aesthetics of Khomsiri’s films and their reliance on the Gothic conventions in the construction of the characters and the environments they inhabit.
Australian Radio Listeners and Television Viewers: Historical Perspectives, Bridget Griffen-Foley (2020)
Authors: Brien Donna Lee
Published: December 2022

Review of: Australian Radio Listeners and Television Viewers: Historical Perspectives, Bridget Griffen-Foley (2020)

Cham: Palgrave Macmillan, 167 pp.,

ISBN 978-3-03054-636-6, h/bk, AUD 79

ISBN 978-3-03054-639-7, p/bk, AUD 79

ISBN 978-3-03054-637-3, e-book, AUD 66
Enhancement in Activity and Reusability of Dry Amberlyst-15 Catalyst by
Thermal Treatment for Production of Biodiesel from Karanja Oil
Authors: Gupta Arun Kumar , Deo Goutam
Published: December 2022

The effect of preheating Amberlyst-15 catalyst used for the biodiesel production reaction of Karanja
oil was studied. The preheated Amberlyst-15 samples were characterized for their surface area and
pore volume and by SEM, TGA and FTIR spectroscopy. A preheat temperature of 473 K was found to
optimum. At this temperature, the surface area had increased and the sulfonic acid groups of Amberlyst-15
were retained. At 473 K preheated Amberlyst-15 gradually deactivated with reuse from a biodiesel
yield of 85% to 27% in four runs at a reaction temperature of 393 K and methanol to oil ratio of 60:1.
For the power-law model, the reaction order was 0.65, the rate constant at 373 K was 0.027 h-1 and
activation energy was 86.98 kJ/mol.
Psidium guajava L. (Common Guava) Peel, Pulp and Leaves as Natural Sources of Antioxidants, Antimicrobials and Photoprotective Agents for Development of Sun Protection Cosmeceuticals
Authors: Dewage D.D.D.H. , Samarakoon S.M.G.K. , Karunaratne S.H.S. , Rajapakse C.S.K.
Published: December 2022

Sunscreens with natural ingredients for skin care become a new trend in cosmetology as it protects skin against photo-aging and dermatologic disorders. Therefore, the goal of this study was to evaluate the antioxidant, antimicrobial and photoprotective properties of methanolic extracts of leaves, peel and pulp of Psidium guajava L. to investigate their potentials to be used as sources of cosmeceutical ingredients for sun protection. Chemical constituents of the plant parts were extracted into methanol by maceration. Among the extracts, leaf extract exhibited higher DPPH free radical scavenging activity (IC50 = 89.56 ± 0.97 μg/mL), than that of peel and pulp extracts. The highest total phenolic content (TPC) and total flavonoid content (TFC) were found to be in the leaf extract. All extracts demonstrated antibacterial activity against the examined potential pathogens in cosmetic products. Among the extracts, leaf extract showed the highest photoprotective property with the sun protection factor (SPF) of 30.38 ± 0.22 at 2 mg/mL indicating its potential to be used in the development of sunscreen formulations.
1,2,3-Triazoles containing Thiazole-Piperazine Moieties:
Synthesis, Biological Assessment and Molecular Docking
Authors: Veeranki Krishna Chaitanya , Pochampally Jalapathi , Maroju Ravi Chander , Thumma Vishnu , Boddu Lakshmi Satya
Published: December 2022

A novel series of thiazole-triazole-piperazine multi hybrids was designed for antimicrobial activity
and the synthetic method for this series has been developed by copper catalyzed 1,3-dipolar
cycloaddition of thiazole-based azide with Boc-piperidine based alkyne in the presence of CuSO4 and
sodium ascorbate. Boc deprotection followed by alkylation of piperidine moiety in hybrid derivatives
was also carried out. All the target compounds were confirmed using FTIR, 1H NMR, 13C NMR and
LC-MS spectral techniques. These compounds were screened for the antimicrobial activity against
bacteria and fungi. The antimicrobial activities are also comparable to standard drugs ampicillin and
clotrimazole. All the molecules showed good to moderate activity and supported by molecular docking
studies and ADME prediction.
Synthesis of Multi-Substituted 4,5-Dihydrofurans: Microwave Assisted Reaction of
β-Ketonitriles, Aldehydes and Pyridinium Phenacyl Salts via [1+1+3]
Knoevenagel-Michael-Oxa-Michael Cyclization Triple Cascade Sequence
Authors: Chimaladenne Venkateswarlu , Surapureddi Sri Rama Krishna , Valluru Krishna Reddy , Kampli Anil , Brahman Pradeep Kumar , Gudise Veera Babu , Vijaya Laxmi Somarapu
Published: December 2022

A microwave assisted protocol for the development of fully substituted dihydrofurans has been explained
as a three component triple cascade reaction between pyridinium ylide, phenacyl nitriles and aldehydes.
This [1+1+3] annulation protocol produced the dihydrofurans having two stereocentres. A total of 14
molecules have been synthesized with high chemical yields.
Fifty Shades of HOXB7 - Unfolding the Enigma of Tamoxifen Resistance and Metastasis in ER+ Breast Cancer
Authors: Andalib K. M. Salim , Didarul Islam Kazi Mohammed , Habib Ahsan , Sukumar Saraswati
Published: December 2022

It is still an enigma why breast cancers develop tamoxifen resistance despite ongoing expression of the estrogen receptor and the mystery behind the distant metastasis in these tumors. Several underlying molecular mechanisms that confer resistance and metastasis are understood but a common thread is yet to be discovered. Series of evidence have established homeodomain protein HOXB7 as a master regulatory transcription factor that plays role in angiogenesis, proliferation, invasiveness, migration and drug resistance. The overexpression of HOXB7 in tamoxifen resistant breast cancer patients has prompted the notion that it could be the common thread. In this study, we connected the dots from literature and built a network that elucidates the expanding impact of HOXB7 in both tamoxifen resistance and distant metastasis in ER+ breast cancer cells, making it an attractive therapeutic target. But, due to its extreme homology with other HOX proteins, it has been difficult to achieve a high level of specificity. An intriguing approach to inhibit HOXB7 function could be targeting the upstream regulators of HOXB7. Application of computational biology - designing and synthesizing RNA targeting tools (siRNAs/shRNAs/miRNAs), delivered as nanoparticles for stable, selective, and efficient knockdown, could be a fascinating strategy.
Potential Assessment of 80 kW Floating Solar Photovoltaic System (FSPV) at Kaptai lake, Bangladesh
Authors: Ahmad Kanij , Rahman Arifur , Mahmud Al
Published: December 2022

Based on the massive amount of electricity generated, the world's lifestyle and economy have greatly expanded. However, due to the scarcity of fossil fuels, the provision of power is under pressure in this country. Renewable energy provides an exception at this point, and solar energyâ€”among all the renewable energy sourcesâ€”plays a prominent role because it is environmentally friendly and indestructible. The cost and accessibility of land, however, poses a significant obstacle to the construction of land-based, large-scale solar power plants in Bangladesh. In a riverine nation like Bangladesh, a floating solar photovoltaic system offers a solution with a lot more possibilities. This research will outline the potential for floating solar photovoltaic systems in Bangladesh's Kaptai lake area and discuss feasible investigations with location prospect, FSPV costs, project revenue, environmental aspects and further research opportunities. The potential investigation for the establishment of FSPV based on financial parameters will be validated in this paper using RET-screen energy management software.
Valoración de prácticas sociales que hacen uso de especies animales no humanas
Authors:   Universidad Pedagógica Nacional, Bogotá, Colombia, Páramo Pablo , Burbano Andrea ,   Universidad Pedagógica Nacional, Bogotá, Colombia,   Universidad Colegio Mayor de Cundinamarca, Bogotá, Colombia, Cruz Norella ,   Universidad Pedagógica Nacional, Bogotá, Colombia, Hernández Sandra ,   Universidad Pedagógica Nacional, Bogotá, Colombia
Published: December 2022

Introducción: Los científicos han explorado las capacidades intelectuales de los animales, su importancia para la salud física y emocional de los humanos, su uso como sujetos en la investigación biomédica y psicológica, pero se ha prestado poca atención a las valoraciones que hacen las personas del común sobre estas prácticas sociales. El objetivo de esta investigación fue presentar los resultados sobre las valoraciones de prácticas de divertimiento, producción industrial, investigación biológica y psicológica, que involucran animales, a partir de las dimensiones: ética, legal, las capacidades intelectuales, los beneficios para la salud física y emocional de las personas y la preocupación por su bienestar. Método: Se construyó un instrumento online a partir una frase mapa compuesto por 28 ítems, que exploran la evaluación de 255 personas, hombres y mujeres sobre estas prácticas, bajo la condición de tener o no mascota. Las respuestas se analizaron mediante un análisis de escalamiento multidimensional. Resultados: Queda en evidencia la preocupación de las personas por las condiciones en que se usan los animales, en particular, de quienes tienen o han tenido mascota. Conclusiones: Los hallazgos se discuten a partir del soporte de las facetas incluidas en la frase mapa y la propuesta para nuevos estudios sobre prácticas sociales que involucre animales en la población general.
CATATAN ATAS FORMULASI KEBIJAKAN PERUBAHAN TARIF PAJAK PERTAMBAHAN NILAI (PPN) DI INDONESIA
Authors: Aryani Lanatasya , Tambunan Maria R.U.D.
Published: December 2022

AbstraksiThe formulation of the Value-added tax (VAT) rate change policy is one of the government's efforts in implementing tax reform. The formulation of this policy consists of an increase in the VAT rate and adopt multiple-rate VATs. The goals are to raise tax revenue for the Indonesian government and recover from the pandemic's economic consequences. Nevertheless, most citizens think that this policy will harm them. This study aims to review the formulation process of the VAT rate change policy. This study uses a qualitative methodological approach and literature study method as the data collection technique. The result shows that the increase in the VAT rate has opened opportunities to optimize the country's revenue. Furthermore, adopt multiple-rate VATs also has opened opportunities to minimize the distortion caused by the provision of the VAT exemption facilities that lack of accuracy. However, the increase in the VAT rate has  increased the price of the products and services and burden the citizens. Adopt multiple-rate VAT has also increased the compliance cost for the taxpayer and administration cost for the government.Keywords: value added tax, tax rate, tax policyAbstrakFormulasi kebijakan perubahan tarif PPN di Indonesia menjadi salah satu upaya pemerintah dalam melaksanakan reformasi perpajakan. Kebijakan perubahan tarif PPN terdiri dari kenaikan tarif PPN dan penggunaan skema multitarif PPN. Kebijakan tersebut disusun oleh pemerintah dengan tujuan untuk meningkatkan penerimaan negara dan memulihkan perekonomian akibat pandemi. Namun, kebijakan tersebut justru memperoleh respons yang buruk dari masyarakat karena dinilai akan memberikan dampak negatif bagi masyarakat. Penelitian ini betujuan untuk menganalisis proses penyusunan formulasi kebijakan perubahan tarif PPN. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan teknik pengumpulan data kualitatif berupa kajian kepustakaan kajian pustaka sebagai teknik pengumpulan datanya. Hasil dari penelitian ini menunjukkan bahwa kenaikan tarif PPN berpeluang bagi negara untuk dapat mengoptimalkan penerimaannya. Kemudian, pengunaan skema multitarif PPN juga berpeluang untuk dapat meminimalisir distorsi yang terjadi akibat pemberian fasilitas PPN yang kurang tepat sasaran. Namun, kenaikan tarif PPN telah menimbulkan kenaikan harga barang dan jasa yang menjadi beban bagi masyarakat. Selain itu, penggunaan skema multitarif PPN akan meningkatkan biaya kepatuhan Wajib Pajak dan biaya administrasi.Kata Kunci: PPN, tarif PPN, kebijakan PPN
IMPLEMENTASI KELURAHAN TANGGUH BENCANA DI BANDUNGREJOSARI KOTA MALANG
Authors: Romadhan Ach. Apriyanto , Rahman Taufik , Sihidi Iradhad Taqwa , Hadi Krishno
Published: December 2022

Malang City has the characteristics of disasters such as floods, landslides, and earthquakes, so community readiness in facing an upcoming disaster is needed. One of the coping strategies is through the Tangguh Disaster Village, which is a community capacity-building activity to protect themselves from the threat of disaster and the community as the main executor in dealing with disasters in disaster-prone areas. The purpose of this study was to determine the implementation of Tangguh Disaster Village in Bandungrejosari Village as an effort to reduce disaster risk in Malang City. The method used in this study is a qualitative method with a descriptive approach. Data collection techniques were obtained through observation, interviews, and documentation. The study results show that in implementing Disaster Resilience, after carrying out disaster socialization and simulation, the community, especially vulnerable groups, can know and understand what they should do when a disaster occurs through disaster risk reduction.
Tinjauan Yuridis Penerapan Sidik Jari Para Penghadap Dalam Minuta Akta Notaris
Authors: Maramis Kezia Deborapingkanangel , Setyowati Rofah
Published: December 2022

AbstractIn making the Minuta Deed, it is required to sign the parties' signatures and attach letters and documents and fingerprints of the parties in accordance with Article 16 number (1) letter c of Law Number 2 of 2014. The research method used in this journal is Normative research. The result of the discussion of this journal is that Notaries are required to sign and fingerprints of the parties in the Minuta deed, Interviewers who are able to sign are obliged to sign their signature on the minimum sheet or paper, while Interviewers who are not able to sign are obliged to affix their fingerprints on a separate sheet of paper which Then attached to the Minuta Deed of the sheet of paper is special and only for tappers who cannot sign or only for the interlocutors put their fingerprints because they cannot sign. Conclusions from this journal related to the application of fingerprints in the Minutes of Notary Deed, there are still many interpretations in practice, especially on the affixing of fingerprints and there are no rules that clearly regulate themKeywords: fingerprint; notary public; minuta deedAbstrakNotaris dalam membuat Minuta Akta wajib mmbubuhkan tanda tangan para pihak dan melekatkan surat dan dokumen serta sidik jari penghadap sesuai dengan Pasal 16 angka (1) huruf c Undang-Undang Nomor 2 Tahun 2014. Metode penelitian yang digunakan dalam jurnal ini adalah penelitian Normatif. Hasil pembahasan jurnal ini adalah Notaris wajib membubuhkan tanda tangan dan sidik jari para penghadap dalam minuta akta, penghadap yang bisa tanda tangan wajib membubuhkan tanda tangannya pada lembar atau kertas minuta sedangkan penghadap yang tidak bisa membubuhkan tanda tangan wajib membubuhkan sidik jarinya pada lembaran kertas tersendiri yang kemudian dilekatkan pada Minuta Akta  lembaran kertas tersebut khusus dan hanya untuk penghadap yang tidak bisa tandatangan atau hanya untuk penghadap membubuhkan sidik jarinya karena tidak bisa tanda tangan. Simpulan dari jurnal ini terkait dengan penerapan sidik jari dalam Minuta Akta Notaris masih terdapat banyak penafsiran dalam praktiknya terutama pada pembubuhan sidik jari dan belum ada peraturan yang mengatur secara tegas.Kata Kunci: sidik jari; notaris; minuta akta
Group of Pregnant Women: A Proposal for Health Promotion and Education
Authors: Castro Silvestre Fernanda , Araújo Monteiro Tiago
Published: December 2022

The present article seeks to show the benefit of the educational action with the pregnant women who were assisted in a Primary Health Care Unit in Fortaleza. The meetings took place monthly with the contribution and organization of a team of health professionals, addressing topics related to different spheres of pregnancy, such as: mental health, infectious diseases during pregnancy, clarification of doubts and myths related to pregnancy, in addition to health promotion by encouraging physical activity. The group made it possible to improve adherence and maintenance of follow-up in the treatment for syphilis, reducing sedentary lifestyle. There was also greater autonomy of the pregnant woman over the gestational period and better knowledge about the physiological body changes expected for that moment. Some difficulties were found, such as the withdrawal of some participants, the physical structure of the basic unit inadequate to accommodate the number of participants interested in the event and the late start of prenatal care, compromising the total effectiveness that the group could offer. Despite the difficulties, it can be seen that the group had a positive influence, contributing with information so that they could elaborate on their pregnancies, prevent themselves from the risk of infectious diseases and perform physical activities safely and previously guided by a health professional.
Literární dílo jako pretext: pokus o dekompozici a rekompozici
Authors: Mikulášek Alexej
Published: December 2022

V následující studii vnímáme literární text jako pretext k dekompoziční analýze, přičemž nový, resp. námi upravený text (posttext) vrhá interpretační světlo na zkoumaný slovesný objekt ve smyslu ontologickém i axiologickém. Dekompozice pomáhá jednak analyzovat způsob výstavby a bytí původního slovesného artefaktu, rovněž zvýrazňuje funkce, které plní. V první části ukazujeme hodnoty básně Let ze sbírky Pokosená hlina (1999) současného slovenského spisovatele Jozefa Leikerta na pozadí slovosledných dekompozičních strategií, v druhé části pak analyzujeme už hotovou „rekompozici”, resp. slovesnou adaptaci kanonizovaného básnického textu české literatury (poéma Ondřeje Koupila nazvaná Květen, 2020) a její interpretační možnosti vzhledem k pretextu, tedy k poémě Máj (1836) Karla Hynka Máchy.
Tělesnost a moderní doba: příklad ruralismu
Authors: Derková Vladimíra , Kotásek Miroslav
Published: December 2022

Článek se věnuje kulturním proměnám, jimiž prochází v moderní době lidská tělesnost. Pojmenovává hlavní okolnosti, formující dobové pohledy na problematiku těla, přičemž zdůrazňuje prosazování i laickou recepci medicínského a psychologického diskurzu, jež jsou propojeny se zájmy politickými. Přinejmenším stejná závažnost je přisuzována novým vizuálním a hromadně sdělovacím médiím – především fotografiím a novinám. Na obecnější uvedení do relevantních znaků moderny ve vztahu k lidské tělesnosti navazuje konkrétní analýza textů Františka Křeliny a Václava Prokůpka. Tato analýza umožňuje poukázat na relevantnost literárního diskurzu i v konkurenci nových, moderních reprezentačních médií.
Joannici w Polsce
Authors: Wasilkiewicz Kamil
Published: December 2022

Tadeusz Wojciech Lange, Przeoraty  – baliwaty  – komandorie. Zakon św. Jana Jerozolimskiego i jego placówki na terenie Polski, Wydawnictwo Inforteditions, Szlakiem krucjat, XIII, Zabrze-Tarnowskie Góry 2021, ss. 257.