bluuebunny/crossref_metadata_2025 huggingface dataset:
Graphical solutions of the Yang–Baxter Equation with cut strands
Authors: Varga Péter
Published: November 2016

We study the representations of the braid group in a generalization of the Temperley–Lieb algebra. This algebra was introduced by Kloster and contains the diagrams of the TL algebra with cut strands. We address the question of existence of Markov traces on these representations and make some observations on the possibility of their Baxterizations.
Intended Instability for Fast Tracking Control of Linear and Nonlinear Dynamical Systems
Authors: Wang Jiqiang
Published: November 2016

Fast tracking is one of the most important performance indices in servo systems. To ensure fast tracking performance, many design methodologies have been established. This note proposes yet another new method based on the idea of intended instability. This is essentially a framework within which a variety of design approaches can be developed. Specifically, fast tracking through slow switching, fast switching, as well as compound control is explained. Refinement of the design approaches is also brought up. Numerical simulations are performed for the illustration of the corresponding designs.
Special properties of the ring Sn(R)
Authors: Zhang Wanru , Liu Zhongkui
Published: November 2016

Let [Formula: see text] be a ring with compatible endomorphisms [Formula: see text]. We investigate the quasi-Armendariz, Armendariz, McCoy, semicommutative properties and Property (A) of the ring [Formula: see text]. Our results yield more examples of quasi-Armendariz rings, Armendariz rings, McCoy rings, semicommutative rings and rings with Property (A).
f-Racks, f-quandles, their extensions and cohomology
Authors: Churchill Indu R. U. , Elhamdadi Mohamed , Green Matthew , Makhlouf Abdenacer
Published: November 2016

The purpose of this paper is to introduce and study the notions of [Formula: see text]-rack and [Formula: see text]-quandle which are obtained by twisting the usual equational identities by a map. We provide some key constructions, examples and classification of low order [Formula: see text]-quandles. Moreover, we define modules over [Formula: see text]-racks, discuss extensions and define a cohomology theory for [Formula: see text]-quandles and give examples.
Profit of a Supply Chain versus its Decentralization in the Presence of Strategic Customers
Authors: Tian Chen , Xiao Tiaojun
Published: November 2016

A strategic customer is the customer who can intentionally delay purchases and wait for products on sale. In the selling season of seasonal products, there is usually a sale period because product valuation drops significantly. We study the behavior of strategic customers in a supply chain selling seasonal products. Contrary to strategic customers, myopic customers buy or leave, and do not wait. Previous researches with myopic customers suggest that decentralization decreases the supply chain’s profit. We simulate supply chain members’ interaction and learning processes of decisions to investigate how decentralization of a supply chain affects its profit in the presence of strategic customers. We study the effect of customer heterogeneity over product valuation and find that: (i) The profit of the decentralized supply chain is higher than that of the centralized one when the degree of customer heterogeneity is high, the expected product valuation is low, and customers have low time sensitivity. (ii) Decentralization retards delaying purchases of strategic customers. In addition, we find that the endogenization of the sale price can weaken the negative effect of strategic customers on the supply chain’s profit.
Evaluating Taiwanese Bank Efficiency Using the Two-Stage Range DEA Model
Authors: Kong Wei-Hsin , Fu Tsu-Tan , Yu Ming-Miin
Published: November 2016

This paper develops a range directional distance data envelopment analysis (DEA) model to simultaneously deal with the problems of negative data and undesirable outputs in the study of performance measurement with two-stage DEA. We report on the development of this model to handle both positive and negative data in a DEA framework and accommodate the problem of undesirable intermediate outputs in the first stage of operational processes. Unlike previous two-stage DEA models we allow for a nonuniform abatement factor imposing on stage 1’ production technology. Such a model is then applied to evaluate Taiwanese bank efficiencies both at the operational stage and profitability stage in banking activities based on a data set consisting of 35 domestic banks in Taiwan in the period 2007. The results indicate that, by the range directional two-stage data envelopment analysis model, the operational efficiency was smaller than the profitability efficiency. Many banks generated too many performing loans in which independent banks should reduce more performing loans than financial holding company subsidiary banks. Both the ratio of investments to loans and the ratio of nonperforming loans to performing loans did not have significant contributions to the efficiency. This paper is able to provide information for bank operators and researchers on the managerial and strategic implications of how negative data and undesirable outputs affect efficiency and how to measure efficiency appropriately.
Biseparability of 3-qubits density matrices using Hilbert–Schmidt decompositions: Sufficient conditions and explicit expressions
Authors: Ben-Aryeh Y. , Mann A.
Published: November 2016

Hilbert–Schmidt (HS) decompositions and Frobenius norms are used to analyze biseparability of 3-qubit systems, with particular emphasis on density matrices with maximally disordered subsystems (MDS) and on the [Formula: see text] state mixed with white noise. The biseparable form of a MDS density matrix is obtained by using the Bell states of a 2-qubit subsystem, multiplied by density matrices of the third qubit, which include the relevant HS parameters. Using our methods, a sufficient condition and explicit biseparability of the [Formula: see text] state mixed with white noise are given. They are compared with the sufficient condition for explicit full separability given in a previous work.
Canonical formulation of Pais–Uhlenbeck action and resolving the issue of branched Hamiltonian
Authors: Sarkar Kaushik , Sk Nayem , Mandal Ranajit , Sanyal Abhik Kumar
Published: November 2016

Canonical formulation of higher order theory of gravity requires to fix (in addition to the metric), the scalar curvature, which is acceleration in disguise, at the boundary. On the contrary, for the same purpose, Ostrogradski's or Dirac's technique of constrained analysis, and Horowit'z formalism, tacitly assume velocity (in addition to the co-ordinate) to be fixed at the end points. In the process when applied to gravity, Gibbons–Hawking–York term disappears. To remove such contradiction and to set different higher order theories on the same footing, we propose to fix acceleration at the endpoints/boundary. However, such proposition is not compatible to Ostrogradski's or Dirac's technique. Here, we have modified Horowitz's technique of using an auxiliary variable, to establish a one-to-one correspondence between different higher order theories. Although, the resulting Hamiltonian is related to the others under canonical transformation, we have proved that this is not true in general. We have also demonstrated how higher order terms can regulate the issue of branched Hamiltonian.
Connections in sub-Riemannian geometry of parallelizable distributions
Authors: Youssef Nabil L. , Taha Ebtsam H.
Published: November 2016

The notion of a parallelizable distribution has been introduced and investigated. A non-integrable parallelizable distribution carries a natural sub-Riemannian structure. The geometry of this structure has been studied from the bi-viewpoint of absolute parallelism geometry and sub-Riemannian geometry. Two remarkable linear connections have been constructed on a sub-Riemannian parallelizable distribution, namely, the Weitzenböck connection and the sub-Riemannian connection. The obtained results have been applied to two concrete examples: the spheres [Formula: see text] and [Formula: see text].
An Empirical Study of the Textual Content of Online Videos
Authors: Chen Yixin , Wang Wen , He Wenbo , Li Xiaofeng
Published: November 2016

Fuelled by the advancement in multimedia technologies, users across the world have witnessed the proliferation of online videos. Compared with the visual content of these videos, the textual content, for example, titles, tags, or descriptions, has been more broadly exploited in the real-world video data mining or information retrieval tasks. To enhance the understanding of videos, and improve the performance of the tasks such as automatic video annotation, video clustering, and cross-modal tag cleansing, the textual and visual content of videos are combined, through various methods. However, the absence of an empirical study on the properties of these contents makes them less solid to gain satisfactory performance. Therefore, in this paper, we conduct this study to verify the properties of textual content and draw insights from these analyses to promote further developments in video data mining that combine the two contents.
Global stability and Hopf bifurcation of a host–parasite system
Authors: Wei Xuerui , Qiu Zhipeng
Published: November 2016

Understanding the dynamical mechanism of the host–parasite interactions is one of important issues on host–parasite association. In this paper, we formulate a three-dimensional host–macroparasite system to describe the host–parasite interactions, which includes the logistic growth rate of host population, the important free-living stage and the host fecundity reduction due to parasite infection. The purpose of the paper is to investigate the asymptotical behavior of the system. By using the properties of the solution to non-autonomous linear system, the basic production number [Formula: see text] is proved to be a threshold which determines the outcome of the parasites. If [Formula: see text], the parasite will eventually die out, and if [Formula: see text] the parasite will be uniformly persistent. Hopf bifurcation of the system is further studied, and sufficient conditions for the Hopf bifurcation are obtained. By using the singular perturbation techniques, the system is separated into two time scales with a faster time scale for the free-living infective particles and a slower time scale for the population dynamics of host and parasite, and then a complete analysis of the dynamics on the slow manifold is conducted. The theoretical results show that the level of aggregation of parasites within host may influence the persistence and stability of the system.
Epimorphisms, dominions, closed and absolutely closed semigroups
Authors: Alam Noor , Khan Noor Mohammad
Published: November 2016

Firstly, we show that the variety of all left(right) regular bands and the variety of all normal bands are closed in the variety of all left(right) semiregular bands and the variety of all medial semigroups, respectively. Then, we show that the class of all regular medial semigroups satisfying certain condition is absolutely closed.
Paramagnetic bioactive silver- and gold-containing nanocomposites based on humic substances
Authors: Khutsishvili Spartak S. , Tikhonov Nikolay I. , Lesnichaya Marina V. , Dolmaa Gania , Vakul’skaya Tamara I. , Aleksandrova Galina P. , Sukhov Boris G.
Published: November 2016

A novel comparative study of paramagnetic properties of new silver- and gold-containing nanocomposites based on humic substances, extracted from medicinal muds, brown coal and shale deposits of Mongolia, has been carried out by electron paramagnetic resonance (EPR) spectroscopy. The change in the paramagnetic properties of metal nanocomposites obtained after metal introduction as compared with the starting substances has been found out. The dependence of stability, antioxidant activity and spin density on the nature and mass content of metal in the nanocomposites has been determined. Metal-containing nanocomposites are characterized by cw-EPR, X-ray diffraction (XRD) and atomic absorption analysis. It is shown that the resulting magnetic bioactive nanocomposites are stable for a long period thus suggesting their prospective use in medicine.
SIG-dimension conjecture proved for graphs having a perfect matching
Authors: Kumar Ramanjit , Singh Surinder Pal
Published: November 2016

We prove the Boyer’s conjecture for graphs having a perfect matching. That is, if [Formula: see text] is such a graph of order [Formula: see text] then [Formula: see text] We also prove an upper bound for the SIG-dimension of any graph without isolated vertices, along with some other results on SIG-dimension.
Early Cretaceous synrift uplift and tectonic inversion in the Loppa High area, southwestern Barents Sea, Norwegian shelf
Authors: Indrevær Kjetil , Gabrielsen Roy H. , Faleide Jan Inge
Published: November 2016

Tectonic inversion of rift basins is most commonly reported in the literature to occur after rifting has ceased. In contrast, we present evidence for synrift, localized tectonic inversion from the Loppa High area, southwestern Barents Sea and present a model for the formation of inversion structures as a result of differential uplift. The structures are of early Barremian to mid-Albian age (
c
. 131 – 105 Ma) and are focused in or near pre-existing extensional boundary faults along the margins of the Loppa High. Inversion is interpreted to be the result of uplift of the high along its inclined boundary faults, leading to space accommodation problems as uplift was not properly compensated by extension in the region. The model constrains the initiation of uplift of the Loppa High to the early Barremian and shows that the asymmetric margin configuration of the high may have led to a bulk clockwise rotation of the high around a vertical axis during uplift. The cause of uplift is not fully understood, but is suggested to be linked to contemporaneous extreme lithospheric thinning in neighbouring basins to the west. Processes involved may include isostatic flexure, thermal heating, lithological phase changes and/or far-field stresses, although these aspects need to be further tested.
Restoration of thermoregulation after exercise
Authors: Kenny Glen P. , McGinn Ryan
Published: November 2016

Performing exercise, especially in hot conditions, can heat the body, causing significant increases in internal body temperature. To offset this increase, powerful and highly developed autonomic thermoregulatory responses (i.e., skin blood flow and sweating) are activated to enhance whole body heat loss; a response mediated by temperature-sensitive receptors in both the skin and the internal core regions of the body. Independent of thermal control of heat loss, nonthermal factors can have profound consequences on the body’s ability to dissipate heat during exercise. These include the activation of the body’s sensory receptors (i.e., baroreceptors, metaboreceptors, mechanoreceptors, etc.) as well as phenotypic factors such as age, sex, acclimation, fitness, and chronic diseases (e.g., diabetes). The influence of these factors extends into recovery such that marked impairments in thermoregulatory function occur, leading to prolonged and sustained elevations in body core temperature. Irrespective of the level of hyperthermia, there is a time-dependent suppression of the body’s physiological ability to dissipate heat. This delay in the restoration of postexercise thermoregulation has been associated with disturbances in cardiovascular function which manifest most commonly as postexercise hypotension. This review examines the current knowledge regarding the restoration of thermoregulation postexercise. In addition, the factors that are thought to accelerate or delay the return of body core temperature to resting levels are highlighted with a particular emphasis on strategies to manage heat stress in athletic and/or occupational settings.
Permanence for the Discrete Competition Model with Infinite Deviating Arguments
Authors: Chen Baoguo
Published: November 2016

Sufficient conditions are obtained for the permanence of the following discrete model of competition:x1k+1=x1(k)exp {r1kK1k+α1k∑s=0+∞J2sx2k-s/1+∑s=0+∞J2sx2k-s-x1k-δ1k};x2(k+1)=x2(k)exp {r2kK2k+α2k∑s=0+∞J1sx1k-s/1+∑s=0+∞J1sx1k-s-x2k-δ2k}, whereri,Ki,αi,Ji, andδi,i=1,2, are nonnegative sequences bounded above and below by positive constants, andKi>αi,i=1,2.
Optimal Ordering and Pricing Policies for Seasonal Products: Impacts of Demand Uncertainty and Capital Constraint
Authors: Shi Jinzhao , Fung Richard Y. K. , Guo Ju’e
Published: November 2016

With a stochastic price-dependent market demand, this paper investigates how demand uncertainty and capital constraint affect retailer’s integrated ordering and pricing policies towards seasonal products. The retailer with capital constraint is normalized to be with zero capital endowment while it can be financed by an external bank. The problems are studied under a low and high demand uncertainty scenario, respectively. Results show that when demand uncertainty level is relatively low, the retailer faced with demand uncertainty always sets a lower price than the riskless one, while its order quantity may be smaller or larger than the riskless retailer’s which depends on the level of market size. When adding a capital constraint, the retailer will strictly prefer a higher price but smaller quantity policy. However, in a high demand uncertainty scenario, the impacts are more intricate. The retailer faced with demand uncertainty will always order a larger quantity than the riskless one if demand uncertainty level is high enough (above a critical value), while the capital-constrained retailer is likely to set a lower price than the well-funded one when demand uncertainty level falls within a specific interval. Therefore, it can be further concluded that the impact of capital constraint on the retailer’s pricing decision can be influenced by different demand uncertainty levels.
Gamma-Ray Bursts: A Radio Perspective
Authors: Chandra Poonam
Published: November 2016

Gamma-ray bursts (GRBs) are extremely energetic events at cosmological distances. They provide unique laboratory to investigate fundamental physical processes under extreme conditions. Due to extreme luminosities, GRBs are detectable at very high redshifts and potential tracers of cosmic star formation rate at early epoch. While the launch ofSwiftandFermihas increased our understanding of GRBs tremendously, many new questions have opened up. Radio observations of GRBs uniquely probe the energetics and environments of the explosion. However, currently only 30% of the bursts are detected in radio bands. Radio observations with upcoming sensitive telescopes will potentially increase the sample size significantly and allow one to follow the individual bursts for a much longer duration and be able to answer some of the important issues related to true calorimetry, reverse shock emission, and environments around the massive stars exploding as GRBs in the early Universe.
Experimental Analysis of Tensile Mechanical Properties of Sprayed FRP
Authors: Yang Zhao , Wu Kun
Published: November 2016

To study the tensile mechanical properties of sprayed FRP, 13 groups of specimens were tested through uniaxial tensile experiments, being analyzed about stress-strain curve, tensile strength, elastic modulus, breaking elongation, and other mechanical properties. Influencing factors on tensile mechanical properties of sprayed FRP such as fiber type, resin type, fiber volume ratio, fiber length, and composite thickness were studied in the paper too. The results show that both fiber type and resin type have an obvious influence on tensile mechanical properties of sprayed FRP. There will be a specific fiber volume ratio for sprayed FRP to obtain the best tensile mechanical property. The increase of fiber length can lead to better tensile performance, while that of composite thickness results in property degradation. The study can provide reference to popularization and application of sprayed FRP material used in structure reinforcement.
Oxidant Status following Cardiac Surgery with Phosphorylcholine‐Coated Extracorporeal Circulation Systems
Authors: Hatemi Ali Can , Çeviker Kadir , Tongut Aybala , Özgöl İlhan , Mert Murat , Kaya Ayşem
Published: November 2016

Introduction. Extracorporeal circulation (ECC) related systemic oxidative stress is a well‐known entity but the underlying mechanisms are not clearly described. Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine‐coated (PCC) ECC systems. Patients and Methods. Thirty‐two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC, n = 18) and Group II (noncoated, n = 14) ECC circuits. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor‐α (TNF‐α), Interleukin‐1β (IL‐β), Interleukin‐6 (IL‐6), Interleukin‐8 (IL‐8), Interleukin‐10 (IL‐10), and Procalcitonin (PCT) levels were measured at 5 different time points. The association between the oxidative indices levels and PCC system used was analyzed. Results. In Group I TOS and TAS statuses were increased at T1, T2, T3, and T4, while IL‐10 and TNF‐α levels accompanied those raises only at T2 (Group I‐Group II, 4.73 ± 2.04 versus 2.79 ± 0.63, p = 0.002, and 30.56 ± 8.11 versus 23.97 ± 7.8, p = 0.031, resp.). In contrast, mean TAS and TOS levels were similar to baseline at all time points in Group II but IL‐6 and IL‐8 levels were increased at T2 (Group I‐Group II, 16.84 ± 5.63 versus 44.81 ± 17.0, p = 0.001, and 38.88 ± 9.8 versus 46.14 ± 9.25, p = 0.038, resp.). Conclusion. Even coated ECC systems are still incapable of attenuating the inflammatory response to cardiopulmonary bypass (CPB).
Novel Visual Nasogastric Tube Insertion System: A Feasibility and Efficiency Study in a Manikin
Authors: Li Qiaoya , Xie Juan , Wu Jinxing , Guo Rui , Ma Wenwen , Xu Gang , Yang Min , Deng Huisheng
Published: November 2016

Background. Conventional nasogastric tube placement is an essential clinical procedure; however, complications may arise from blind manipulation. We tested the feasibility and efficiency of a visual nasogastric tube insertion system (VNGS) using a manikin. Methods. A microimaging fiber (0.8 mm) was integrated into the nasogastric tube to create the VNGS. Twenty inexperienced physicians were enrolled and assigned to the visual or conventional group. Each physician performed 10 repeated nasogastric tube insertions with visual guidance or the conventional method; another 20 inexperienced medical students received nasogastric tube insertion training using visual guidance or the conventional method. Results. The nasogastric tube successfully reached the stomach and the narrow anatomic structures were visualized with the VNGS. Time required for insertion was significantly shorter in the visual group compared to the conventional group (22.56±3.08 versus 37.30±4.12 seconds, P<0.001). Tube misplacement was observed in 19/100 cases (19%) in the conventional group; no misplacement was observed in the visual group. Less mucosal damage was noted in the visual group (3.43±1.63 versus 9.86±2.31 cm2). Medical students performed better NGT insertions (shorter insertion time and less procedure-related complications) after undergoing the visual guidance training. Conclusions. The VNGS may provide a new technique for nasogastric tube insertion applicable to clinical use or simulation training.
Seismic Evaluation of a Multitower Connected Building by Using Three Software Programs with Experimental Verification
Authors: Zhou Deyuan , Guo Changtuan , Wu Xiaohan , Zhang Bo
Published: November 2016

Shanghai International Design Center (SHIDC) is a hybrid structure of steel frame and reinforced concrete core tube (SF-RCC). It is a building of unequal height two-tower system and the story lateral stiffness of two towers is different, which may result in the torsion effect. To fully evaluate structural behaviors of SHIDC under earthquakes, NosaCAD, ABAQUS, and Perform-3D, which are widely applied for nonlinear structure analysis, were used to perform elastoplastic time history analyses. Numerical results were compared with those of shake table testing. NosaCAD has function modules for transforming the nonlinear analysis model to Perform-3D and ABAQUS. These models were used in ABAQUS or Perform-3D directly. With the model transformation, seismic performances of SHIDC were fully investigated. Analyses have shown that the maximum interstory drift can satisfy the limits specified in Chinese code and the failure sequence of structural members was reasonable. It meant that the earthquake input energy can be well dissipated. The structure keeps in an undamaged state under frequent earthquakes and it does not collapse under rare earthquakes; therefore, the seismic design target is satisfied. The integrated use of multisoftware with the validation of shake table testing provides confidence for a safe design of such a complex structure.
About a Problem for Loaded Parabolic-Hyperbolic Type Equation with Fractional Derivatives
Authors: Sadarangani Kishin B. , Abdullaev Obidjon Kh.
Published: November 2016

An existence and uniqueness of solution of local boundary value problem with discontinuous matching condition for the loaded parabolic-hyperbolic equation involving the Caputo fractional derivative and Riemann-Liouville integrals have been investigated. The uniqueness of solution is proved by the method of integral energy and the existence is proved by the method of integral equations. Let us note that, from this problem, the same problem follows with continuous gluing conditions (atλ=1); thus an existence theorem and uniqueness theorem will be correct and on this case.
Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
Authors: Jaeger Samira , Igea Ana , Arroyo Rodrigo , Alcalde Victor , Canovas Begoña , Orozco Modesto , Nebreda Angel R. , Aloy Patrick
Published: November 2016

Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently approved drug combinations result largely from empirical clinical experience and cover only a small fraction of a vast therapeutic space. Here we present a computational network biology approach, based on pathway cross-talk inhibition, to discover new synergistic drug combinations for breast cancer treatment. In silico analysis identified 390 novel anticancer drug pairs belonging to 10 drug classes that are likely to diminish pathway cross-talk and display synergistic antitumor effects. Ten novel drug combinations were validated experimentally, and seven of these exhibited synergy in human breast cancer cell lines. In particular, we found that one novel combination, pairing the estrogen response modifier raloxifene with the c-Met/VEGFR2 kinase inhibitor cabozantinib, dramatically potentiated the drugs' individual antitumor effects in a mouse model of breast cancer. When compared with high-throughput combinatorial studies without computational prioritization, our approach offers a significant advance capable of uncovering broad-spectrum utility across many cancer types. Cancer Res; 77(2); 459–69. ©2016 AACR.
Prospective Case-Control Study of Abnormal Bleeding after Outpatient Corticosteroid Injection
Authors: Suh-Burgmann Elizabeth , Liu Jennifer Y.
Published: November 2016

Objective: This study is aimed at evaluating the incidence of bleeding among women having outpatient corticosteroid injection compared to matched controls, using mailed surveys and electronic health records. Study Design: Prospective survey study of women receiving outpatient corticosteroid injection for joint or back pain (cases) compared to women matched for visit, diagnosis of joint/back pain, and age, who did not receive an injection (controls). A survey was mailed 45 days following outpatient visit, inquiring about menstrual history, abnormal bleeding, and potential risk factors. The proportion of women reporting abnormal bleeding was compared between cases and controls, and stratified by menopausal status. Results: One thousand and sixty two surveys were mailed to 531 identified cases/control pairs, and 40% response was seen from each group. Of 379 analyzable responders, 135 (36%) were premenopausal and 244 (64%) postmenopausal. Postmenopausal women who had a corticosteroid injection were more likely to report recent abnormal bleeding compared to controls (17 vs. 7%, p = 0.02), whereas rates were similar among premenopausal women (50 vs. 43%, p = 0.39). When logistic regression was performed, injection was associated with bleeding among postmenopausal women, independent of body mass index and hormone use. Conclusions: Corticosteroid injection is associated with increased abnormal vaginal bleeding among postmenopausal women.
The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers
Authors: Kasagi Yuta , Oki Eiji , Ando Koji , Ito Shuhei , Iguchi Tomohiro , Sugiyama Masahiko , Nakashima Yuichiro , Ohgaki Kippei , Saeki Hiroshi , Mimori Koshi , Maehara Yoshihiko
Published: November 2016

Colon cancer-associated transcription 2 (CCAT2) was recently identified as a novel long noncoding RNA transcript encompassing the single-nucleotide polymorphism rs6983267. CCAT2 is overexpressed in colorectal cancer (CRC) where it promotes tumor growth, metastasis, and chromosomal instability, although the clinical relevance of this enhanced expression is unknown. In this retrospective study, CCAT2 expression was evaluated using real-time polymerase chain reaction in 149 CRC patients, and its associations with clinicopathological characteristics, outcome, rs6983267 genotypes, microsatellite status, DNA ploidy, and BubR1 expression were analyzed. CCAT2 expression in cancer tissue was significantly higher than in noncancer tissue (p < 0.001), particularly in cases of metastatic cancer (p < 0.001). However, relative CCAT2 expression levels and rs6983267 genotypes were not correlated with clinicopathological features or patient prognosis. CRC cases demonstrating high CCAT2 expression were all microsatellite stable (p < 0.005). Together, this indicates that CCAT2 expression was associated with microsatellite-stable CRC.
Factors Influencing Repair Outcomes of Vesicovaginal Fistula: A Retrospective Review of 139 Procedures
Authors: Zhou Liang , Yang Tong-Xin , Luo De-Yi , Chen Shu-Lian , Liao Bang-Hua , Li Hong , Wang Kun-Jie , Shen Hong
Published: November 2016

Introduction: We aimed to report the outcomes of patients undergoing vesicovaginal fistula (VVF) repair to identify prognostic factors. Materials and Methods: Patients who underwent VVF repair between January 2009 and October 2015 were reviewed. Primary outcome was fistula closure at 3 months. Results: A total of 123 patients and 139 procedures of VVF repair were reviewed. The overall success rate was 85.6%. There were no significant differences in age (p = 0.476), etiology (p = 0.900), fistula duration (p = 0.491) and number of repairs (p = 0.509) between success and fail group. Moderate or severe perifistula fibrosis and multiple fistula were associated with failure in repair of fistula (70.8 vs. 93.4%, p < 0.001; 62.5 vs. 88.6%, p = 0.005). No difference was seen in success rate of vaginal and abdominal approaches (86.0 vs. 85.0%, p = 0.800). Logistic regression analysis identified fistula number (p = 0.003) and perifistula fibrosis (p = 0.002) as 2 independent prognostic factors. Medium/large fistulas were 3.2 times more likely to fail in repair than small fistulas (OR 3.2, 95% CI 0.95-10.6, p = 0.061). Conclusions: Fistula number and perifistula fibrosis were 2 independent prognostic factors for fistula repair. Unsuccessful closure was more likely in medium/large VVF.
2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial
Authors: Thadhani Ravi , Zella Julia B. , Knutson Danielle C. , Blaser William J. , Plum Lori A. , Clagett-Dame Margaret , Buck Raymond D. , DeLuca Hector F.
Published: November 2016

Background: Vitamin D analogs and calcimimetics are used to manage secondary hyperparathyroidism (SHPT) in dialysis patients. DP001 is an oral vitamin D analog that suppresses parathyroid hormone (PTH) in uremic rats, osteopenic women, and hemodialysis patients. The safety and effectiveness of DP001 suppressing PTH in dialysis patients previously managed with active vitamin D with or without a calcimimetic are presented. Methods: A multicenter, randomized, double-blind study compared DP001 to placebo in hemodialysis patients with serum-intact PTH (iPTH) ≥300 pg/ml. The primary efficacy endpoint was the proportion of patients achieving 2 consecutive ≥30% decreases in iPTH levels during the 12 weeks of treatment. Calcium, phosphorus, calcium × phosphorus product and safety were also evaluated. The responses to DP001 were compared in patients previously treated with both active vitamin D and a calcimimetic to those previously on active vitamin D alone. Results: Sixty-two patients were randomized (n = 34 DP001; n = 28 placebo). At week 12, 78% of all DP001-treated patients and 7% of all placebo-treated patients achieved the primary endpoint (p < 0.0001); iPTH fell 45% in the DP001 group and increased 37% in the placebo group. No patient exceeded the safety threshold of 2 consecutively corrected serum calcium levels ≥11.0 mg/dl. Patients previously on cinacalcet plus active vitamin D also responded to DP001 (n = 10) resulting in a 55% decrease in iPTH, while those on placebo (n = 9) increased by 70%. Conclusion: DP001 safely and effectively suppressed iPTH in hemodialysis patients with SHPT that were previously managed with active vitamin D alone or with a calcimimetic (www.clinicaltrials.gov, NCT01922843).
Wang's Forceps-Assisted Catheter Reposition and Fixation: An Easy and Reliable Rescue Method
Authors: Wang Huiming , Wang Yujuan , Chen Xinghua , Zhu Jili
Published: November 2016

Catheter migration and omental wrap are the most common causes of catheter malfunction, which usually result in catheter removal or replacement. The conventional open surgery for catheter reposition has many disadvantages. A new tunnel is needed throughout the procedure of catheter replacement causing more pain and frustration to the patients. Another drawback is that the incidence of catheter migration after conventional catheter reposition surgery is still as high as it was before the procedure. Wang's forceps, an instrument commonly used in our peritoneal dialysis center, is easy and effective in catheter insertion and fixation. Recently, we have successfully used the Wang's forceps to resolve the catheter displacement for 10 patients, including 1 patient who suffered from catheter tip migration 3 times and had undergone conventional catheter rescue by both open surgery and laparoscopy. This new technique was easy and reliable, and the original tunnel was maintained, which reduced pain and risk of infection in the patients. These advantages may grant the Wang's forceps technique favorable over the conventional surgical approach.
ПСИХОЛОГІЧНІ АКЦЕНТУАЦІЇ У ХВОРИХ ІЗ МЕТАБОЛІЧНИМ СИНДРОМОМ ТА ОЖИРІННЯМ
Authors: Mylytsia K. M.
Published: November 2016

У роботі відтворено психологічний портрет пацієнтів із метаболічним синдромом та ожирінням на підставі анкетування 212 хворих за коротким опитувальником  ВOОЗ для оцінки якості життя (WHOQOL – BREF) методикою Айзенка. Виявлено, що в міру прогресування ожиріння, розвиваються психоемоційні  девіації, вираження порушень фізичного стану, знижується якість життя, що особливо демонструється при тяжких ступенях ожиріння, та потребує негайного та ефективного медичного втручання.
ЕФЕКТИВНІСТЬ НЕЙТРАЛІЗАЦІЙ ТРИВОЖНОСТІ У ДІТЕЙ, ЩО ХВОРІЮТЬ НА БРОНХІАЛЬНУ АСТМУ
Authors: Burbela E. I. , Volianska L. A. , Stetsenko V. V. , Kozak D. V.
Published: November 2016

Проведено вивчення ефективності доповнення симптоматичного лікування бронхіальної астми (БА) арт-терапією у дітей шкільного віку з врахуванням індивідуальних особливостей психосоматичного стану. Арт-терапевтичний комплекс доданий до стандартної терапії позитивно вплинув на зниження виразності тривожності у хворих дітей. В процесі навчання правильному диханню засобами арт-терапії у хворих на БА зменшено тривожність: особистісну у 58,33 %, проти 10,53 % при стандартній схемі та ситуативну у 66,67 %, проти 10,53 %, що відображає достовірно (р<0,05) вищу ефективність доповненого симптоматичного лікування.
КЛІНІЧНІ ОСОБЛИВОСТІ ПЕРЕБІГУ ХВОРОБИ У ПАЦІЄНТІВ ІЗ МУЛЬТИФОКАЛЬНОЮ ВИСОКОДИФЕРЕНЦІЙОВАНОЮ ТИРЕОЇДНОЮ КАРЦИНОМОЮ
Authors: Kobrynska N. Ya.
Published: November 2016

Проведено порівняльний аналіз моно- та мультифокальних високодиференційованих тиреоїдних карцином. Усього проаналізовано 2904 хворих на рак щитоподібної залози, з них 693 із мультифокальною і 2211 з монофокальною карциномою. У результаті проведеного аналізу встановлено, що у пацієнтів із мультифокальною високодиференційованою  тиреоїдиною карциномою, порівняно з хворими на монофокальну високодиференційовану карциному, значно рідше зустрічається фолікулярний тип пухлини. У них частіше реєструються неінкапсульовані пухлинні утворення та множинні первинні вогнища в щитоподібній залозі, а також відмічаються рецидиви хвороби, що зумовлювало частіші проведення повторних операційних втручань.
АНАЛІЗ СЕЗОННОСТІ ВИНИКНЕННЯ ВАД НЕВРАЛЬНОЇ ТРУБКИ В РІВНЕНСЬКІЙ ОБЛАСТІ
Authors: Yevtushok B. A.
Published: November 2016

Дане дослідження присвячене вивченню сезонних коливань частоти виникнення вад невральної трубки (ВНТ) в популяції Рівненської області. Вища частота  виникнення ВНТ спостерігалася в лютому та серпні, однак ця відмінність не була статистично достовірною. Отримані результати сприяють поглибленню знань про епідеміологічні особливості ВНТ для подальшого вивчення факторів ризику та підвищення ефективності профілактичних заходів.
СУДИННІ ПУХЛИНИ І СУДИННІ МАЛЬФОРМАЦІЇ У ДІТЕЙ: ФОРМУЛЮВАННЯ ДІАГНОЗУ ЗГІДНО З СУЧАСНОЮ КЛАСИФІКАЦІЄЮ
Authors: Benzar I. M.
Published: November 2016

Пацієнтів із судинними аномаліями (СА) завжди нелегко виділити та чітко охарактеризувати, враховуючи велику кількість нозологічних одиниць, а також неоднорідну термінологію, яку використовують у багатьох медичних закладах. Метою роботи був аналіз групи пацієнтів із СА, які потребують стаціонарного обстеження і лікування в умовах мультидисциплінарного центру. Адаптація і впровадження єдиної системи класифікації є першим кроком до встановлення вірного діагнозу і визначення тактики лікування судинних аномалій. Клінічні прояви судинних аномалій мають  чіткі вікові особливості. Хоча судинні пухлини зустрічаються в 10 разів частіше, ніж судинні мальформації, серед госпіталізованих дітей судинні пухлини склали 31,7 %, а СМ – 68,3%.
ОПТИМІЗАЦІЯ РЕАБІЛІТАЦІЙНИХ ПРОГРАМ У САНАТОРНИХ УМОВАХ ДЛЯ ПАЦІЄНТІВ ІЗ ПЕРВИННИМ ГОНАРТРОЗОМ ЗАЛЕЖНО ВІД КЛІНІКО-ПАТОГЕНЕТИЧНОГО ВАРІАНТУ ПЕРЕБІГУ
Authors: Bakaliuk T. H.
Published: November 2016

Запропоновано новий підхід до розробки індивідуальних програм реабілітації у пацієнтів із первинним гонартрозом (ПГА). Для визначення клінічної ефективності застосування комплексних програм медичної реабілітації у хворих на ПГА розроблено схему індексної оцінки тяжкості патології та ефективності лікування на санаторно-курортному етапі реабілітації. Доведено, що для оптимізації реабілітації у санаторних умовах необхідне індивідуально орієнтоване застосування природних, фізіотерапевтичних, фізичних та альтернативних чинників лікувально-відновлювальних комплексів, що зумовлює зменшення частоти ускладнень, збільшення ефективності реабілітації та подовження тривалості ремісії.
ПРОСТОРОВА ПЕРЕБУДОВА КАМЕР СЕРЦЯ ПРИ АРТЕРІАЛЬНІЙ ГІПЕРТЕНЗІЇ У МАЛОМУ КОЛІ КРОВООБІГУ
Authors: Slabyi O. V. , Hnatiuk M. S.
Published: November 2016

В експерименті встановлено, що пострезекційна артеріальна легенева гіпертензія призводить до розвитку легеневого серця і виражених змін  планіметричних та об’ємних параметрів його камер. Виявлено, що легеневе серце характеризується розширенням його частин із переважним зростанням просторових характеристик правого шлуночка та правого передсердя. Найбільше змінені планіметричні та об’ємні параметри камер легеневого серця виявлені при його декомпенсації, для визначення якої важлива роль належить резервним об’ємам шлуночків.
МІТОТИЧНА АКТИВНІСТЬ КЛІТИН СЛИЗОВОЇ ОБОЛОНКИ ПІЛОРИЧНОГО ВІДДІЛУ ШЛУНКА ЩУРІВ В УМОВАХ ДІЇ ЕПІХЛОРГІДРИНУ, АДАПТОГЕНУ Й АНТИОКСИДАНТУ
Authors: Smirnov A. S. , Mirzebasov M. A.
Published: November 2016

В експериментах на білих щурах-самцях вивчали характер впливу епіхлоргідрину на процеси поділу клітин слизової оболонки пілоричного відділу шлунка щурів, а також експериментально обґрунтовували можливість використання екстракту ехінацеї пурпурової і тіотриазоліну з метою корекції виникаючих змін. Введення епіхлоргідрину знижує мітотичну активність клітин слизової оболонки пілоричного відділу шлунка щурів. Зменшення мітотичної активності зберігається протягом семи діб після припинення інгаляцій епіхлоргідрину. Як екстракт ехінацеї пурпурової, так і тіотриазолін, при введенні їх щурам, на яких не діяв епіхлоргідрин, не викликають змін мітотичної активності клітин слизової оболонки пілоричного відділу шлунка. Застосування екстракту ехінацеї пурпурової, а також використання тіотриазоліну на тлі інгаляцій епіхлоргідрину перешкоджають виникненню зменшення мітотичної активності, яка викликається епіхлоргідрином.
РІВЕНЬ ІНФОРМОВАНОСТІ ТА СТАВЛЕННЯ ДО ПИТАНЬ ТРАНСПЛАНТОЛОГІЇ СЕРЕД СТУДЕНТІВ ВИЩОЇ ДЕРЖАВНОЇ ШКОЛИ ІМЕНІ ПАПИ ІОАНА-ПАВЛА II В БЯЛІЙ ПІДЛЯСЦІ
Authors: Pyshch P. , Shlyfyrchyk A. , Kovalenko M.
Published: November 2016

Ця стаття повністю присвячена темі донорства органів, тканин і клітин. Такий терапевтичний підхід, визнаний у всьому світі, часто дає шанс на одужання і значно поліпшує якість життя, дозволяючи працювати і виконувати повсякденні справи. У найважливішій частині роботи представлено і проаналізовано результати досліджень щодо рівня знань і думок з приводу донорства органів, проведеного  серед  130  медичних  та  немедичних  студентів  у Вищій державній школі Папи Іоанна-Павла II в м. бяла Подляска в березні та квітні 2015 року. результати показують значний вплив дослідження на рівні знань і думок на тему донорства. Проведене дослідження показало, що більшість респондентів підтримують донорство. Проте існують етичні дилеми серед людей, які чекають пожертвування і потенційних донорів. різноманітні думки з деяких питань донорства органів були представлені   в цій статті. У зв’язку із запереченнями і критикою на адресу даного методу лікування,необхідні дії, що порушують стереотипи про донорство органів і підвищують рівень інформованості про те, що це донорство насправді означає і які має переваги.
The Yin–Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling
Authors: Zhuang Jianhui , Luan Peipei , Li Hailing , Wang Kai , Zhang Pei , Xu Yawei , Peng Wenhui
Published: November 2016

Objective—

DNA methylation plays an important role in chronic diseases such as atherosclerosis, yet the mechanisms are poorly understood. The objective of our study is to indicate the regulatory mechanisms of DNA methylation in vascular smooth muscle cells (VSMCs) and its roles in atherosclerosis.

Approach and Results—

In ApoE
−/−
mice fed a Western diet, DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, significantly attenuated atherosclerotic lesions (20.1±2.2% versus 30.8±7.5%;
P
=0.016) and suppressed DNA methyltransferase activity and concomitantly decreased global 5-methylcytosine content in atherosclerotic lesions of ApoE
−/−
mice. Using a carotid ligation model, we found that 5-aza-2′-deoxycytidine also dramatically inhibited neointimal formation (intimal area: 2.25±0.14×10
4
versus 4.07±0.22×10
4
μm
2
;
P
<0.01). Abnormal methylation status at the promoter of ten–eleven translocation 2, one of the key demethylation enzymes in mammals, was ameliorated after 5-aza-2′-deoxycytidine treatment, which in turn caused an increase in global DNA hydroxymethylation and 5-hydroxymethylcytosine enrichment at the promoter of Myocardin. In vitro, 5-aza-2′-deoxycytidine treatment or DNA methyltransferase 1 knockdown decreased global 5-methylcytosine content and restored Myocardin expression in VSMCs induced by platelet-derived growth factor, thus preventing excessive VSMCs dedifferentiation, proliferation, and migration. Furthermore, DNA methyltransferase 1 binds to ten–eleven translocation 2 promoter and is required for ten–eleven translocation 2 methylation in VSMCs.

Conclusions—

The inhibitory effects of DNA demethylation on global 5-methylcytosine content and ten–eleven translocation 2 hypermethylation in atherosclerotic aorta can recover 5-hydroxymethylcytosine enrichment at the Myocardin promoter and prevent VSMC dedifferentiation and vascular remodeling.
Conventional Versus Compression-Only Versus No-Bystander Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest
Authors: Fukuda Tatsuma , Ohashi-Fukuda Naoko , Kobayashi Hiroaki , Gunshin Masataka , Sera Toshiki , Kondo Yutaka , Yahagi Naoki
Published: November 2016

Background:

Conventional cardiopulmonary resuscitation (CPR) (chest compression and rescue breathing) has been recommended for pediatric out-of-hospital cardiac arrest (OHCA) because of the asphyxial nature of the majority of pediatric cardiac arrest events. However, the clinical effectiveness of additional rescue breathing (conventional CPR) compared with compression-only CPR in children is uncertain.

Methods:

This nationwide population-based study of pediatric OHCA patients was based on data from the All-Japan Utstein Registry. We included all pediatric patients who experienced OHCA in Japan from January 1, 2011, to December 31, 2012. The primary outcome was a favorable neurological state 1 month after OHCA defined as a Glasgow-Pittsburgh Cerebral Performance Category score of 1 to 2 (corresponding to a Pediatric Cerebral Performance Category score of 1–3). Outcomes were compared with logistic regression with uni- and multivariable modeling in the overall cohort and for a propensity-matched subset of patients.

Results:

A total of 2157 patients were included; 417 received conventional CPR, 733 received compression-only CPR, and 1007 did not receive any bystander CPR. Among these patients, 213 (9.9%) survived with a favorable neurological status 1 month after OHCA, including 108/417 (25.9%) for conventional, 68/733 (9.3%) for compression-only, and 37/1007 (3.7%) for no-bystander CPR. In unadjusted analyses, conventional CPR was superior to compression-only CPR in neurologically favorable survival (odds ratio [OR] 3.42, 95% confidence interval [CI] 2.45–4.76;
P
<0.0001), with a trend favoring conventional CPR that was no longer statistically significant after multivariable adjustment (OR
adjusted
1.52, 95% CI 0.93–2.49), and with further attenuation of the difference in a propensity-matched subset (OR 1.20, 95% CI 0.81–1.77). Both conventional and compression-only CPR were associated with higher odds for neurologically favorable survival compared with no-bystander CPR (OR
adjusted
5.01, 95% CI 2.98–8.57, and OR
adjusted
3.29, 95% CI 1.93–5.71), respectively.

Conclusions:

In this population-based study of pediatric OHCA in Japan, both conventional and compression-only CPR were associated with superior outcomes compared with no-bystander CPR. Unadjusted outcomes with conventional CPR were superior to compression-only CPR, with the magnitude of difference attenuated and no longer statistically significant after statistical adjustments. These findings support randomized clinical trials comparing conventional versus compression-only CPR in children, with conventional CPR preferred until such controlled comparative data are available, and either method preferred over no-bystander CPR.