bluuebunny/crossref_metadata_2025 huggingface dataset:
Educ@dom: comparative study of the telemonitoring of patients with type 2 diabetes versus standard monitoring—study protocol for a randomized controlled study
Authors: Turnin Marie-Christine , Schirr-Bonnans Solène , Martini Jacques , Buisson Jean-Christophe , Taoui Soumia , Chauchard Marie-Christine , Costa Nadège , Lepage Benoît , Molinier Laurent , Hanaire Hélène
Published: July 2017

Background

The global prevalence of type 2 diabetes is considerable. To avoid or delay its chronic complications, patients with type 2 diabetes should improve blood glucose management by adapting their life style. This involves changing the way in which diabetes is controlled. We believe that, thanks to technological innovations in connected health-monitoring devices, the telemonitoring of type 2 diabetes patients using therapeutic educational tools is likely to help them adapt their treatment and lifestyle habits, and therefore improve blood glucose management.

Methods

This is a multicenter, randomized, controlled, prospective study. The primary objective is to compare the efficacy of telemonitoring to standard monitoring in terms of changes in glycated hemoglobin levels (HbA1c) after a 1 year follow-up period. The secondary objectives are clinical (changes in knowledge, physical activity, weight, etc.) and medical-economic. 282 patients are required (141 patients in each group) to satisfy the primary objective. For patients in the intervention group, the device will be given to them for 1 year and then withdrawn during the second year of follow-up.

Conclusions

The anticipated benefits of this research are an improvement in blood glucose management in patients with type 2 diabetes by improving their lifestyle whilst rationalizing recourse to consultations in order to reduce the incidence of complications and cost in the long term. If the results of this study show that management of type 2 diabetes by tele monitoring is clinically effective and economical, this device could then be made available to a larger diabetic patient cohort.
Anemia in Patients With Resistance to Thyroid Hormone α: A Role for Thyroid Hormone Receptor α in Human Erythropoiesis
Authors: van Gucht Anja L M , Meima Marcel E , Moran Carla , Agostini Maura , Tylki-Szymanska Anna , Krajewska Malgorzata-Walasek , Chrzanowska Krystyna , Efthymiadou Alexandra , Chrysis Dionisios , Demir Korcan , Visser W Edward , Visser Theo J , Chatterjee Krishna , van Dijk Thamar B , Peeters Robin P
Published: July 2017

Context

Patients with resistance to thyroid hormone (TH) α (RTHα) are characterized by growth retardation, macrocephaly, constipation, and abnormal thyroid function tests. In addition, almost all RTHα patients have mild anemia, the pathogenesis of which is unknown. Animal studies suggest an important role for TH and TH receptor (TR)α in erythropoiesis.

Objective

To investigate whether a defect in TRα affects the maturation of red blood cells in RTHα patients.

Design, Setting, and Patients

Cultures of primary human erythroid progenitor cells (HEPs), from peripheral blood of RTHα patients (n = 11) harboring different inactivating mutations in TRα (P398R, F397fs406X, C392X, R384H, A382fs388X, A263V, A263S), were compared with healthy controls (n = 11). During differentiation, erythroid cells become smaller, accumulate hemoglobin, and express different cell surface markers. We assessed cell number and cell size, and used cell staining and fluorescence-activated cell sorter analysis to monitor maturation at different time points.

Results

After ∼14 days of ex vivo expansion, both control and patient-derived progenitors differentiated spontaneously. However, RTHα-derived cells differentiated more slowly. During spontaneous differentiation, RTHα-derived HEPs were larger, more positive for c-Kit (a proliferation marker), and less positive for glycophorin A (a differentiation marker). The degree of abnormal spontaneous maturation of RTHα-derived progenitors did not correlate with severity of underlying TRα defect. Both control and RTHα-derived progenitors responded similarly when differentiation was induced. T3 exposure accelerated differentiation of both control- and RTHα patient–derived HEPs.

Conclusions

Inactivating mutations in human TRα affect the balance between proliferation and differentiation of progenitor cells during erythropoiesis, which may contribute to the mild anemia seen in most RTHα patients.
Effect of Various Carbonization Temperatures on ZIF-67 Derived Nanoporous Carbons
Authors: Guo Yanna , Tang Jing , Salunkhe Rahul R , Alothman Zeid Abdullah , Hossain Md Shahriar A , Malgras Victor , Yamauchi Yusuke
Published: July 2017

Here we have prepared ZIF-67 derived nanoporous carbons (NPCs) under different carbonization temperatures ranging from 800 to 1000 °C, and investigated the effect of the temperature on the porous structure. Raman analysis confirms that the graphitic degree of the obtained samples increases as the applied carbonization temperature is increased. With the gradual increase of the graphitic degree, the surface area is decreased.
The public service-motivated volunteer devoting time or effort: a review and research agenda
Authors: Costello Joyce , Homberg Fabian , Secchi Davide
Published: July 2017

The purpose of this conceptual article is to further our understanding of how evolving volunteer trends impact on volunteering intensity. The aim is to provide clarity by applying to the volunteer literature a theoretical framework that can be adapted to different ways in which people volunteer and thus may inform subsequent empirical work. First, we address academic debates concerning the measurement of volunteer effort. Second, we propose using public service motivation (PSM) theory as a means to understand the motivation of volunteers across sectors. We suggest that different PSM dimensions may be more dominant in certain volunteer settings than others and incorporate person–organisation fit as a means to understand the relationship between PSM and volunteering intensity. Finally, this article proposes directions for future research.
La escenografía del milagro en la consagración de la catedral de Jaén (1660)
Authors: Cuesta García de Leonardo María José
Published: July 2017

La Contrarreforma utiliza mecanismos sorprendentes para persuadir hacia un comportamiento también útil a la monarquía, la cual justifica sus intervenciones bélicas en la defensa de la religión. En un momento de fanáticas movilizaciones que reivindican el Dogma de la Inmaculada y los hallazgos de reliquias de santos, nos interesan esos mecanismos –sus impactantes arquitecturas efímeras, escenografías e imágenes-, transmisores de mensajes a los jiennenses, quienes vivieron las fiestas de la consagración de su nueva catedral en un ambiente de exaltación.
La mujer como tentación maligna
Authors: Martínez de Lagos Miren Eukene
Published: July 2017

El imaginario de los castigos y tormentos a los pecadores es probablemente una de las creaciones más originales y persuasivas de la iconografía medieval. Tan seductoras como repulsivas, la capacidad de comunicación de estas imágenes es infalible, ya que se convierten en agentes activos que interactúan directamente con el público al que van dirigidas. Entre todas ellas hay una que destaca por su rotundidad y por su impacto visual y que la historiografía francesa ha denominado femme-aux-serpents, iconografía predilecta para ilustrar el castigo a la lujuria.
Ikusgai-eremu elektromagnetiko osoan zehar igorpen sintonizagarria duten BODIPY laser-koloratzaileak
Authors: Avellanal-Zaballa Edurne , Esnal Ixone , Bañuelos Jorge
Published: July 2017

Lan honetan, molekula-egiturak BODIPY deritzen koloratzaileen propietate fotofisikoetan duen eragina aztertzen da, gehienbat alde ikusgai gorritik urdinera laser sintonizagarrien ingurune aktiboa garatzeko. BODIPYaren ordezkapen-patroiaren arabera propietate espektroskopikoak modula eta optimiza daitezke. Horrela, BODIPYaren oinarrizko kromoforoa abiapuntutzat hartuta (absortzio/igorpen eremu ikusgai berde/horian) aldaketak egin dira egitura molekularrean banda espektralak lerrokatzeko, bai eremu urdinera (heteroatomoak meso posizioan sartuz), bai eremu gorrira (π sistema deslokalizatua hedatuz). Ondorioz, koloratzaile komertzialekin konparatuz gero, eremu espektral ikusgai osoa betetzen duten BODIPY koloratzaile berriak garatu dira, propietate fotofisiko eta laser hobetuekin.
GIBaren aurkako txertoaren bila
Authors: Torralba Johana , Goikoetxea Estibaliz , Apellaniz Beatriz
Published: July 2017

GIB birusa, giza historian zehar egon den pandemiarik hilgarrienetariko baten eragilea da, HIESA alegia. Nahiz eta azken urteetan HAART terapia antirretrobiralari esker heriotza tasa asko murriztu den, infekzio berrien kopurua etengabe emendatzen ari da. Hori dela eta, pandemiarekin azkenik amaitu ahal izateko txerto prebentibo baten garapena tresna eraginkorrena izan daitekeela dirudi. Hala ere, birusak garatu dituen estrategia natural desberdinek eta immunizazioz sortu nahi diren antigorputz neutralizatzaileen ezaugarri bereziek oso zaila egiten dute infekziotik babestuko lukeen txertoaren garapena. RV144 entsegu klinikoaren eraginkortasun apalek eta espektro zabaleko antigorputz neutralizatzaileekin immunizazio pasiboz lorturiko emaitzek iradokitzen dute hurbilago gaudela txerto eraginkor baten garapena lortzetik. Orain arte hainbat txerto mota erabili diren arren, emaitza onik ez da lortu. Hala ere, sakon aztertzen ari da bai immunogeno naturalen egitura, bai immunogenoak ezagutzen dituzten antigorputzen egitura, eta badirudi, besteak beste, ikerketa horiek bide be- rriak irekiko dituztela txerto berrien diseinuan.
Blokezko kopolimero eta nanopartikula magnetikoetan oinarritutako nanokonposatu film meheak: nanopartikulen dispertsioaren eragina
Authors: Barandiaran Irati , Kortaberria Galder
Published: July 2017

Nanokonposatu organiko/inorganikoak gizartean sortzen ari diren behar berriei erantzuteko hautagai egokiak dira, izan nanoelektronikan, fotonikan, energia- pilaketan, katalisian, estalduretan, etab. Horien artean blokezko kopolimero eta nanopartikula magnetikoetan oinarritutako nanokonposatuak dauzkagu, zeintzuek aplikazio horietarako propietate interesgarriak dituzten. Lan honetan blokezko kopolimero eta nanopartikula magnetikoz osatutako nanokonposatu film meheak aztertu dira, nanopartikulen dispertsiorako teknika desberdinak landuz eta horiek blokezko kopolimeroen nanoegituraketan duten eragina aztertuz, baita nanokonposatuei transferitutako propietate magnetikoak ere.
Genero desadostasuna Haur Hezkuntzan. Irakasleon erronka berria
Authors: Gorrotxategi Maite , Álvarez Amaia
Published: July 2017

En el momento en que nacemos, estamos clasificados como hombres o mujeres. Los médicos definen nuestro género basándose en nuestros genitales. A partir de entonces, los adultos nos tratan de una manera particular según nuestro género, no nos dan la opción de elegir. Sin embargo, la identidad de género se desarrolla a lo largo de la vida y no siempre coincide con el sexo asignado. La educación de la primera infancia es muy importante en este proceso porque es cuando los y las niñas comienzan a identificar su género. Es por eso que las actitudes de las familias y docentes son tan importantes. Dado que hoy en día este es un tema bastante desconocido, en este trabajo analizaremos los conocimientos que las y los maestros tienen sobre la diversidad de género y sexo. Para ello, utilizaremos entrevistas y cuestionarios hechos al profesorado y un trabajo de observación en el aula. Por último, debido al escaso conocimiento sobre este tema en los entornos educativos, también se ofrecerá una lista de recursos para los y las docentes de la primera infancia y las familias.
¿Qué buscan los usuarios de medios digitales de oración? Análisis de usos y gratificaciones de Rezandovoy
Authors: Riezu Xabier
Published: July 2017

Este artículo pretende realizar una contribución al conocimiento de la religión en los medios digitales, mediante un estudio de caso desde la perspectiva de los usos y gratificaciones. Rezandovoy es un servicio digital de oración que utilizan a diario miles de personas en todo el mundo hispanohablante. El presente trabajo estudia, empleando técnicas cualitativas y cuantitativas, las motivaciones que están detrás de su uso. Los resultados de una encuesta online que recibió 5.391 respuestas válidas muestran que, aunque las gratificaciones espirituales son las más valoradas, este tipo de webs y apps cumplen también funciones identitarias y sociales, además de ofrecer gratificaciones características de cualquier dispositivo digital.
LA REPRESENTACIÓN FÍLMICA DE LA MEMORIA PERSONAL: LAS PELÍCULAS DE MEMORIA
Authors: Rincón Yohn María , Torregrosa Puig; Marta , Cuevas Álvarez Efrén
Published: July 2017

El artículo busca definir y analizar lo que denomina como películas de memoria, filmes de ficción o documental que tienen como tema principal la memoria personal Dichas películas ponen en primer plano la duplicidad presente/pasado –inherente tanto a la memoria como a la imagen cinematográfica–, que se despliega en un tiempo personal o subjetivo. Para representar la memoria personal, estos filmes se articulan en torno a tres características que consiguen captar la dinámica de la memoria como facultad humana: la subjetividad, la indiscernibilidad temporal y la performatividad.
A Case of Perforation of the Gallbladder in Association with Typhoid Fever
Authors: Idjradinata Ponpon , Suroto-Hamzah E. , Sugiri Sugiri
Published: July 2017

The purpose of this paper is to report a case of rupture of gallbladder in a child in association with typhoid fever.
Diaphragmatic Paralysis
Authors: Zulkifli S. , Monintja H. E. , Assin M. Sutan
Published: July 2017

To the authors knowledge not one publication on diaphragmatic paralysis in the newborn is available in the Indonesian literature. This paper communication is to report some cases of diaphragmatic paralysis with Erb's palsy in the newborn and in early infancy detected in Jakarta.
Child Health Problems in Indonesia
Authors: Saroso Julie Sulianti
Published: July 2017

Community survey and hospital data related to morbidity in children urns presented.Morbidity point prevalence rate by age pier 1000 population was found highest in preschool children. Acute respiratory infections, infection and inflammation of the skin and subcutaneous tissues and diarrheal disease were the most prevalent diseases among this age group.Hospital data showed that Tetanus was the most serious disease. Data on the availability of health services and the utilization of these services for prevention and m case of illness as well as steps to strengthen these services was also presented.
Treatment of In-Patient Pulmonary Tuberculosis
Authors: Rasjid Rasmin
Published: July 2017

The progress of a tuberculous lesion was discussed. A treatment regimen of pulmonary tuberculosis in the wards mas layed out, especially for the "Persahabatan" Hospital, Jakarta. Rifampicin seems to be a potent drug. However, for developing countries like Indonesia it is still very expensive. Possibly a combinations of INH + RMP + EB will be most effective at present. Only a daily treatment is carried out in ”Persahabatan” Hospital.
Postgraduate Pediatric Training Programme in the Department of Child Health, Medical School University of Indonesia, Jakarta
Authors: Monintja H.E. , Karjomanggolo W.T. , Sutejo R.
Published: July 2017

Paediatrics is a major subject in undergraduate as well as postgraduate medical training. Demographic data show that 44% of the population in Indonesia as well as in other developing countries belongs to the paediatric age group. The objective of the training of paeditrician should be relevant to the needs of the society in child health care using the available potentials in the society and with the participation of the society. In this paper the determinant of objective, the objective, the methodology, the evaluation and the feedback system of the postgraduate paediatric training programme in the Department of Child Health, Medical School, University of Indonesia, is briefly described.
Accidental Poisoning in Children with Special Reference to Kerosene Poisoning
Authors: Aldy Dachrul , Rusdidjas Rusdidjas , Siregar Helena
Published: July 2017

A 6-year (1970- 1975) retrospective study of kerosene poisoning in children admitted to the General Hospital, Medan, is presented. The total number of admission was 10.643, 124 of which were kerosene poisoning. Tho mortality was 4.8%. In North Sumatera the incidence of kerosene poisoning along with the consumption of kerosene showed an increasing trend. The male to female ratio was 75 by 49 (3:2). The majority of cases were brought to the hospital within one hour after ingestion of kerosene. The presenting symptoms in the majority of cases were coughing (78.8%), vomiting (48.9%), dyspnoe 29%, fever 20.9%, brochopneumonia 12.9%, cyanosis 4.0%, and shock 1.6%. Treatment consisted of broad spectrum antibiotics, intravenous fluid, and oxygen administration. Kerosene in the household of the patients was used as fuel, either for cooking, or light source. More than 75% of the cases belonged to the lower socioeconomic class.
C3 and C4 Complements in Glomerular Disorders in Children
Authors: Alatas H. , Wirya I.G.N. Wila , Tambunan T.
Published: July 2017

Seventy children who were hospitalized for kidney diseases in the Nephrological ward Department of Child Health, University of Indonesia, Jakarta were used in this study. Thirty seven patients sufferfng from acute poststreptococcal Glomerulonephritis (A.G.N.), 3 patients with Membranoproliferative Glomerulonephritis (M.P.G.N.) and 30 patients with Nephrotic Syndrome due to other causes were examined for complement concentration. A total of 80 samples were examined for C3 and 25 samples for C4 concentration using the immunediffusion plates. Almost all patients with A.G.N. and M.P.G.N. showed depression of C3. C4 concentration was normal except in 2 patients, 1 with A.G.N. and the other With M.P.G.N. This suggest activation of complement at the C3 level by the alternating pathway in most of the patients. C3 concentration in A.G.N. patients returned to normal after 8-10 weeks. In MPGN the depression was persistent in 2 patients, while in 1 patient it returned to normal level after 3 months of Immunosuppressive treatment.
Department of Child Health, Medical School, University of Indonesia, Jakarta
Authors: Sudjarwo Sri Rochani , Sularyo Sunarwati , Sudiyanto Sudiyanto , Rasjid Aliamran
Published: July 2017

From studies of the Indonesian children in good socio-economic condition a conclusion can be made, that they are all in a good nutritional status, so that this physical dimension can be used as indices of health of the Indonesian preschool children. But this so-called ethnic standard, using an ”optimum” group, must be kept up-to-date and reviewed every 5 years or so (Janes, 1975), remembering the probable existence of a secular trend. It is still a task to do for establishing the most effective methods to bring about an all-round improvement in the health and nutritional status of the children as great as possible, and to enable the children to get more benefit from the education which is available.
Breast milk and Bottle Milk in relation with gastroenteritis
Authors: Rumondang Rumondang , Suharyono Suharyono , Budiarso Aswitha , Utomo Mugijo K. , Wiharta Adnan S.
Published: July 2017

A study on 1043 children aged 3 days to 2 years hospitalized in the Department of Child Health, from 1 January to 31 December 1976, was made fo find out the relation between breast milk and bottle milk with gastroenteritis, especially concerning bacterial, fungal infection and fat malabsorption.
The Importance of Breastmilk in Acute Neonatal Enterocolitis and Other Enteric Disease
Authors: Ruspandji Tri , Suharyono Suharyono , Budiarso Aswitha , Tumbelaka W.A.F.J. , Halimun E.M.
Published: July 2017

In the Department of Child Health, Dr. Cipto Mangunkusumo Hospital, a case of necrotizing enterocolitis with resection about 50 cm of the ileum was reported.
Highly Sensitive NO2 Detection and DMP Sensing at Room Temperature using Flexible SWNT Thick Film Sensor
Authors: Kumar Deepak , Chaturvedi Poornendu , Chouksey Abhilasha , Jha Pika , Rawat J.S.B.S. , Tandon R.P. , Chaudhury P.K.
Published: July 2017

 

 Low cost; easy to fabricate and flexible single wall carbon nanotubes thick film resistor (SWNT-TFR) for detailed study of NO2 detection is reported. SWNT-TFR was fabricated by vacuum filtration technique on flexible polycarbonate membrane. SWNT-TFR sensor shows selective response to NO2. The response increases from 1.47 per cent to 17.34 per cent with increasing the NO2 concentration from 0.2 ppm to 10 ppm, respectively. Different energy sources, IR, thermal and UV were explored for achieving fast recovery of the SWNT-TFR sensor. The results showed that the gas sensor gives immediate and fast recovery in the presence of UVC light. The calculated detection limit is less than 764 ppt for NO2. We are also presenting sensing of dimethyl methylphosphonate (DMMP) as a simulant of sarin. SWNT-TFR gives repeatable response of ~2.7 per cent for 500 ppm of DMMP. This work suggests the possibility to utilise SWNTs-TFR as NO2 sensors for air-quality monitoring. 
The culture of popular sports and religion
Popüler spor kültürü ve din
Authors: Akgül Mehmet Haşim , Kaplan Turgut
Published: July 2017

Sport and religion had different definitions throughout the history. Roots of sport and religion phenomenon are as old as history of humanity, when common ground is searched.  Sport has a changing relationship with religion along the history and according to data of sport history, sport has an aspect comes from religion. Relation between sport and religion has continued in different periods, while in modern times this relation has become a contradiction. This study, which has themed Popular Sport Culture and Religion, investigates effects of popular culture, religion and sport on doing exercises. Relationship between ‘’ exercise for healthy life’’ phenomenon and tendency of being religious phenomenon which are ever-mounting in community has presented as descriptive in this applied research study. Universe of study is composed of people who are making sport/exercise for healthy life in Konya and 197 male, 112 female attendants are reached. Research findings has interpreted as statistically. Positive relationships and significant discrepancies has found between popular sport/exercise culture and piety, according to gained data.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetTarih boyunca spor ve din çeşitli tanımlamalara konu olmuştur. Bu tanımlamaların ortak noktasına bakıldığında; spor ve din olgularının kökleri insanlık tarihi kadar eskidir. Spor tarihinin verilerine göre kökeninde dinsel bir yan bulunduğu sporun, tarih boyunca din ile değişen bir ilişkisi olmuştur. Çeşitli dönemlerde din ve spor ilişkisi birlikteliğini devam ettirirken, modern zamanlarda arasındaki ilişki neredeyse bir karşıtlık ilişkisi şeklinde düşünüle gelmiştir.  Popüler Spor Kültürü ve Din konulu bu çalışma, günümüzde popüler kültürün, din ve spor/egzersiz yapmaya etkilerini araştırmaktadır. Uygulamalı bir araştırma olan çalışmada, toplumda gittikçe yaygınlaşan ‘sağlıklı yaşam için egzersiz’ yapma ile gittikçe artan dindarlaşma eğilimi arasındaki ilişki betimsel olarak ortaya konulmuştur. Bu araştırmanın evrenini, Konya’da sağlıklı yaşam için spor/egersiz yapan insanlar oluşturmuş ve 197 erkek, 112 kadın katılımcıya ulaşılmıştır.  Elde edilen araştırma bulguları istatistiksel olarak yorumlanmıştır.  Elde edilen bulgulardan hareketle, popüler spor/egzersiz kültürü ile dindarlık göstergeleri arasında olumlu ilişkiler ve anlamlı farklılıklar bulgulanmıştır.
Sustained Attention Ability Affects Simple Picture Naming
Authors: Jongman Suzanne R.
Published: July 2017

Sustained attention has previously been shown as a requirement for language production. However, this is mostly evident for difficult conditions, such as a dual-task situation. The current study provides corroborating evidence that this relationship holds even for simple picture naming. Sustained attention ability, indexed both by participants’ reaction times and individuals’ hit rate (the proportion of correctly detected targets) on a digit discrimination task, correlated with picture naming latencies. Individuals with poor sustained attention were consistently slower and their RT distributions were more positively skewed when naming pictures compared to individuals with better sustained attention. Additionally, the need to sustain attention was manipulated by changing the speed of stimulus presentation. Research has suggested that fast event rates tax sustained attention resources to a larger degree than slow event rates. However, in this study the fast event rate did not result in increased difficulty, neither for the picture naming task nor for the sustained attention task. Instead, the results point to a speed-accuracy trade-off in the sustained attention task (lower accuracy but faster responses in the fast than in the slow event rate), and to a benefit for faster rates in the picture naming task (shorter naming latencies with no difference in accuracy). Performance on both tasks was largely comparable, supporting previous findings that sustained attention is called upon during language production.
Phenotypic diversity drives paracrine drug tolerance
Authors: Kuilman Thomas , Peeper Daniel S
Published: July 2017

Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses. Tumors are often heterogeneous, and as a result, therapy‐resistant cells are present even before the start of treatment. Resistance is commonly mediated via genetic changes. However, in this issue of EMBO Molecular Medicine, Smith et al () report that phenotypic heterogeneity can contribute to resistance as well.
A Model for Epigenetic Inhibition via Transvection in the Mouse
Authors: Rodriguez Juan D , Myrick Dexter A , Falciatori Ilaria , Christopher Michael A , Lee Teresa W , Hannon Gregory J , Katz David J
Published: July 2017

Transvection—a phenomenon in which the allele on one chromosome genetically interacts with its paired allele on the homologous chromo-some.....

Transvection is broadly defined as the ability of one locus to affect its homologous locus in trans. Although it was first discovered in the 1950s, there are only two known cases in mammals. Here, we report another instance of mammalian transvection induced by the Cre/LoxP system, which is widely used for conditional gene targeting in the mouse. We attempted to use the germline-expressed Vasa-Cre transgene to engineer a mouse mutation, but observe a dramatic reduction of LoxP recombination in mice that inherit an already deleted LoxP allele in trans. A similar phenomenon has previously been observed with another Cre that is expressed during meiosis: Sycp-1-Cre. This second example of LoxP inhibition in trans reinforces the conclusion that certain meiotically expressed Cre alleles can initiate transvection in mammals. However, unlike the previous example, we find that the inhibition of LoxP recombination is not due to DNA methylation. In addition, we demonstrate that LoxP inhibition is easily alleviated by adding an extra generation to our crossing scheme. This finding confirms that the LoxP sites are inhibited via an epigenetic mechanism, and provides a method for the use of other Cre transgenes associated with a similar LoxP inhibition event. Furthermore, the abrogation of LoxP inhibition by the simple addition of an extra generation in our crosses establishes a unique mouse system for future studies to uncover the mechanism of transvection in mammals.
Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging inCaenorhabditis elegans
Authors: Baxi Kunal , Ghavidel Ata , Waddell Brandon , Harkness Troy A , de Carvalho Carlos E
Published: July 2017

Reproduction and aging are intertwined. While lifespan and reproductive strategies vary greatly among animals, the progeny production period generally...

Aging in eukaryotes is accompanied by widespread deterioration of the somatic tissue. Yet, abolishing germ cells delays the age-dependent somatic decline in Caenorhabditis elegans. In adult worms lacking germ cells, the activation of the DAF-9/DAF-12 steroid signaling pathway in the gonad recruits DAF-16 activity in the intestine to promote longevity-associated phenotypes. However, the impact of this pathway on the fitness of normally reproducing animals is less clear. Here, we explore the link between progeny production and somatic aging and identify the loss of lysosomal acidity—a critical regulator of the proteolytic output of these organelles—as a novel biomarker of aging in C. elegans. The increase in lysosomal pH in older worms is not a passive consequence of aging, but instead is timed with the cessation of reproduction, and correlates with the reduction in proteostasis in early adult life. Our results further implicate the steroid signaling pathway and DAF-16 in dynamically regulating lysosomal pH in the intestine of wild-type worms in response to the reproductive cycle. In the intestine of reproducing worms, DAF-16 promotes acidic lysosomes by upregulating the expression of v-ATPase genes. These findings support a model in which protein clearance in the soma is linked to reproduction in the gonad via the active regulation of lysosomal acidification.
Double whip stitch for free graft femoral fixation in ACL reconstruction: experimental study on porcine model
Authors: Buescu Cristian Tudor , Dudescu Cristian Mircea , Caterev Sergiu , Lucaciu Dan Gheorghe Osvald
Published: July 2017

Background and aims. Using free quadriceps tendon graft for anterior cruciate ligament (ACL) reconstruction has become more popular in the last years due to the low morbidity at the harvest site and biomechanical and structural properties similar to other types of graft (hamstring and patellar tendons). As long as the tibial tunnel fixation with interference screws is considered the standard fixation, femoral fixation is still an open subject. Even though the most common type of femoral tunnel fixation are the cortical suspension devices, the type of suture used for tying the graft to the loop is still evaluated and discussed. We aimed to evaluate the resistance and elongation of a double whip stitch used for tying a tendon to the loop of a cortical suspension device.Method. We used 10 porcine flexor digitorum profundus as free graft for a graft-suture-cortical suspension device construct using the double whip stitch. The total length of the construct and tendon length were recorded before and after the test was performed. Tensioning curves, total construct elongation and maximum tension at breaking point were electronically recorded on the testing device's software. The mean values and coefficient of variance were assessed.Results. We noted the breaking of the suture wire where the wires passed through the loop of the cortical suspension device as final point for all tests. The mean of maximum load was 505.68N (Max=639.38 N; min=358.93 N; SD=82.88078 N) and the mean of total construct elongation was 39.54784mm (Max= 48.60466 mm; min=31.74853 mm; SD=4.85371 mm).Conclusion. With some minor improvement in technique and graft preconditioning and pretensioning, the double whip stitch can be used in connecting a free tendon to a cortical suspension device.
Outcomes of robotic-assisted radical prostatectomy for patients in two extreme age-groups (< 50 years vs > 65 years)
Authors: Coman Radu-Tudor , Crisan Nicolae , Andras Iulia , Bud Gabriela , Matei Deliu-Victor , De Cobelli Ottavio , Coman Ioan , Bocsan Ioan-Stelian
Published: July 2017

Background and aims. To assess the outcomes of robotic radical prostatectomy in two different age subgroups of pre-operatively potent patients: younger than 50 years and older than 65 years.Methods. We included in the present study a number of 202 patients with prostate cancer divided into two groups: 99 patients older than 65 years (group 1) and 103 patients younger than 50 years (group 2).Results. More than half of the younger patients were low-risk vs 57% of the older patients who were high-risk. Overall positive surgical margins rate was 21.2% in group 1 vs 12.1% in group 2. The early biochemical recurrence at 6 months after radical prostatectomy was 4% in group 1 vs 11.6% in group 2. The continence rate at 6 months was similar between the two groups and was not correlated with the patients’ age (p=0.72), nerve-sparing (p=0.3 for group 1, p=0.92 for group 2) or pathological staging (overall p=0.81, p=0.89 in group 1 and p=0.63 in group 2). We observed a significantly higher rate of potency for patients in group 2 (91.5% vs 47.2%, p<0.0001). The most important factor associated with the regain of potency at 6 months after the procedure was the age of the patient (p<0.0001), independently of the type of nerve-sparing performed.Conclusions. Age seems to be the most important predictor of the regain of potency after robotic radical prostatectomy. Patients should be counseled accordingly in order to have realistic expectations about the functional results after robotic-assisted surgery.
Imaging Strategies for Suspected Acute Cranial Shunt Failure: A Cost-Effectiveness Analysis
Authors: Pershad Jay , Taylor Andrew , Hall M. Kennedy , Klimo Paul
Published: July 2017

OBJECTIVES:

We compared cost-effectiveness of cranial computed tomography (CT), fast sequence magnetic resonance imaging (fsMRI), and ultrasonography measurement of optic nerve sheath diameter (ONSD) for suspected acute shunt failure from the perspective of a health care organization.

METHODS:

We modeled 4 diagnostic imaging strategies: (1) CT scan, (2) fsMRI, (3) screening ONSD by using point of care ultrasound (POCUS) first, combined with CT, and (4) screening ONSD by using POCUS first, combined with fsMRI. All patients received an initial plain radiographic shunt series (SS). Short- and long-term costs of radiation-induced cancer were assessed with a Markov model. Effectiveness was measured as quality-adjusted life-years. Utilities and inputs for clinical variables were obtained from published literature. Sensitivity analyses were performed to evaluate the effects of parameter uncertainty.

RESULTS:

At a previous probability of shunt failure of 30%, a screening POCUS in patients with a normal SS was the most cost-effective. For children with abnormal SS or ONSD measurement, fsMRI was the preferred option over CT. Performing fsMRI on all patients would cost $27 627 to gain 1 additional quality-adjusted life-year compared with CT. An imaging pathway that involves CT alone was dominated by ONSD and fsMRI because it was more expensive and less effective.

CONCLUSIONS:

In children with low pretest probability of cranial shunt failure, an ultrasonographic measurement of ONSD is the preferred initial screening test. fsMRI is the more cost-effective, definitive imaging test when compared with cranial CT.
Pilot study assessing reflection ability of practicing Australian and New Zealand ophthalmologists using the Groningen Reflection Ability Scale
Authors: Mack Heather G. , Filipe Helena Prior
Published: July 2017

This article was migrated. The article was not marked as recommended. Background: The benefits of reflective practice to foster high standards of patient care are well documented. Reflective practice is a continuing professional development (CPD) requirement of the Royal Australian and New Zealand College of Ophthalmologists (RANZCO), the Australian Health Practitioners Regulation Agency (AHPRA) and the Medical Council of New Zealand (MCNZ). However, the level of reflection ability among Australian and New Zealand ophthalmologists has not been previously measured. Methods: Fellows of RANZCO were surveyed in late 2011, 18 months after reflective practice became an AHPRA requirement for medical registration. Fellows undertook the college regular triennial CPD feedback survey and were given the option to proceed to the Groningen Reflection Ability Scale (GRAS, English version) test questions using a 5-point Likert scale (1=strongly disagree, 5=strongly agree). Results were collated using SurveyMonkey®. Average response for each question was calculated, and a single score calculated for the responding ophthalmologists. Results: One hundred and sixty Fellows participated in the survey, 89% Australian and 11% from New Zealand, and 81% male. Fifteen percent of practicing ophthalmologists responded. On average, responding ophthalmologists showed a high level of personal reflection ability, with total score 90.78 (possible range 23 - 115). Small numbers, potential bias among responders and lack of a control group limit the study. Conclusions: RANZCO ophthalmologists responding to the GRAS instrument in 2011 on average demonstrated a high level of personal reflection ability. This study is a useful baseline for future studies of ophthalmologists' reflective practice and of educational interventions designed to improve reflective behavior.
“I LIGHT MY CANDLE FROM YOURS…”: ANTHROPOLOGICAL ASPECTS OF MODERN LIBRARY SERVICES FOR SCIENTISTS
Authors: Kolesnykova T. O.
Published: July 2017

Introduction. Integration of knowledge and communications, the movement for open access to knowledge lead to the emergence of factors that update the philosophy of functioning and development of university libraries. There is a need to comprehend the ongoing innovations in the activities of university libraries in the world. Purpose. The study assumes understanding of the substantial changes in the library services for scientists related to Open Access and the new role of university libraries – a partner in the production, preservation and spread of knowledge. Methodology. On the basis of empirical and theoretical methods, the features of modern university libraries are considered. They include shift of the priority vector towards the services for an author-scientist and support of the philosophy of open access to knowledge. The study identifies and analyzes the anthropological aspects of communicative and informational awareness of reality by university researchers and librarians. The realities of modern services for scientists of Ukraine are examined based on the experience of the Scientific and Technical Library of Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan. The observations and surveys of scientists, librarians, publishers of scientific periodicals allow analyzing the anthropological aspects concerning new digital library services. The aspects affect: 1) relationship between communicants; 2) explanations of why it is the authors-researchers who have been at the center of the attention of libraries, why they are provided with exactly these services and exactly in this way; 3) levels of impact of new services on both scientists and librarians. Originality. It is established that in the process of communicative and informational awareness of reality, there are changes in the dimension of scientists and university librarians, namely, the ways of their behaviour and the communicative features associated with the development of Open Access and the new role of university libraries as partners in the production, preservation and spread of knowledge. Conclusions. The leading role of university libraries in the implementation of digital initiatives of scientific communication, based on free access to knowledge, leads to changes: 1) in the dimension of scientists and librarians, namely, the ways of their behavior and communicative features; 2) in the emotional, psychological, physical states of librarians as intermediaries between two conflicting requirements – ensuring stability in the activities of the library and the need for changes in the services it provides.
Briefing: Embodied carbon dioxide assessment in buildings: guidance and gaps
Authors: Giesekam Jannik , Pomponi Francesco
Published: July 2017

The construction industry, through its activities and supply chains as well as the operation of the assets that it creates, is a major contributor to global greenhouse gas emissions. Embodied carbon dioxide emissions associated with the construction of new assets constitute a growing share of whole-life emissions across all project types and make up nearly a quarter of all annual emissions from the UK built environment. Yet these embodied emissions are still rarely assessed in practice, owing to the perceived difficulty and lack of supporting guidance for practitioners conducting an assessment. This briefing paper retraces recent advances in the field of embodied carbon dioxide assessment and highlights existing and forthcoming practical guidance that could support more widespread assessment. The paper constitutes a where-to rather than a how-to, directing assessors towards appropriate resources, of which there are many. Although the paper does highlight some remaining gaps in the field and identifies corresponding research priorities, recent additions to the body of guidance are generally sufficient to support more widespread assessment. Now, the industry must demonstrate its commitment to tackling climate change by using this guidance to drive deeper carbon dioxide reduction.
Harina de hígado de bovino en la alimentación de broilers
Authors: Rosero Marco
Published: July 2017

Normalmente, en la elaboración de dietas para aves, se utilizan productos o subproductos que son de consumo directo para el hombre, lo que ocasiona escasez y consecuentemente, aumento de los precios de dichos ingredientes, es por esto que se vuelve necesaria la búsqueda de nuevos componentes dietéticos o materias primas que permitan satisfacer en forma barata y eficiente los requerimientos nutritivos de las aves.
President's Message: A Bright Future Ahead for BHAC
Authors: Melnyk Bernadette Mazurek
Published: July 2017

No abstract available
What affect heart in SAM: structure or function
Authors: Sharma Ashutosh Kumar , Gaur Ajay , Sharma Agrawal Neetu
Published: July 2017

Background: Objective of present study was to assess structural and functional cardiac changes in children with severe acute malnutrition between the age of 6 month to 59 months. Setting: The study conducted in Department of paediatrics, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior. A prospective case control study. Participants: 100 cases and 100 controls enrolled based on the selection criteria, Control group was selected from patient came in Out Patient Department. Children from 6 months to 59 months of age with weight for height ranging <-3SD and/or Mid Upper Arm Circumference (MUAC) <11.5 cm and/or edematous malnutrition and/or visible severe wasting). Selection of cases and control were done through random sampling method.Methods: All enrolled admitted children were stabilised after admission as per WHO protocol of management. After that they undergone echocardiographic and electrocardiographic evaluation and data were collected and Analysed.Results: In this study, study group show decrease in dimension of heart i.e. IVSd (p-value-0.02413), LVEDd (p-value-0.0000017), PLVWd (p-value-0.01493), LVEDs (p-value-0.0000263), PLVWs (p-value-0.0000254) more affected during diastole than systole, increased HR (p-value-0.0044), shorten PR intervals (p-value-0.0001) and shorten P wave(p-value-0.000385), QT (p-value-0.044) and QTc (p-value-0.00968) as compared to control group. Pericardial effusion found in 16 cases in study group (8 mild and 8 trace).Conclusions: Early evaluation of cardiac function in malnourished child will significantly affect the management of Severe Acute Malnutrition to prevent deaths from Severe Acute Malnutrition.
Compactação em Latossolos e suas relações com o crescimento radicular do milho
Authors: De Vares Rossetti Karina , Centurion José Frederico
Published: July 2017

A intensificação do tráfego de máquinas nas atividades agrícolas pode predispor o solo a uma condição de fragilidade, quando se considera o nível de tensão aplicada em cada sistema de manejo. Objetivou-se com este trabalho, avaliar sob diferentes estados de compactação em Latossolos a viabilidade de utilização de atributos físicos como indicadores de qualidade do solo e suas consequências sobre o sistema radicular do milho. O experimento foi conduzido no ano agrícola 2013/14, em delineamento de blocos casualizados em Latossolo Vermelho Distrófico (LVd) e Latossolo Vermelho Eutroférrico (LVef) em parcelas subdivididas, com quatro repetições. Os tratamentos foram: T0= preparo convencional, sem tráfego adicional; T1 e T2= duas e quatro passadas do trator de 4 t, respectivamente, T3 e T4= duas e quatro passadas do trator de 10 t, respectivamente. Foram coletadas amostras de solo nas camadas de 0-0,10 e 0,10-0,20 m, para determinação da densidade (Ds), porosidade, resistência do solo à penetração (RP) e parâmetros radiculares do milho. A RP elevou-se em 86% para o LVd e LVef, em comparação do T0 ao T4. A redução da macroporosidade (Mac) em LVd de 0,19 para 0,15 m3 m-3 influenciou positivamente o comprimento radicular do milho em comparação a condição sem tráfego adicional. Os atributos RP, Ds, Mac, podem ser utilizados como identificadores de possíveis compactações em LVd e LVef.
Personificando la revolución. Espartero: carisma en la Revolución de 1840 y su llegada a la Regencia
Embodying revolution. Espartero: charisma in the 1840 Revolution and his arrival to the regency
Authors: Cañas de Pablos Alberto
Published: July 2017

RESUMEN La revolución de septiembre de 1840 supuso la abdicación de la viuda de Fernando VII, María Cristina de Borbón, y la llegada del manchego Baldomero Espartero al poder. Pocos meses después se convirtió en regente único durante algo más de dos años, hasta su caída posterior y partida al exilio londinense. En todo el proceso de presión sobre la madre de Isabel II, además de la firma de la restrictiva ley de Ayuntamientos, jugó un papel fundamental la admiración que despertaba el héroe de Luchana entre gran parte de las capas populares. La meta de este texto se fundamenta en descubrir por qué, desde la guerra carlista, se consideraba que él sería capaz de garantizar las libertades establecidas en la Constitución de 1837 frente a los obstáculos y abusos perpetrados por María Cristina y sus acólitos. Con este fin, se combina el estudio de fuentes primarias (prensa, debates parlamentarios) con los trabajos más recientes sobre esta cuestión.   PALABRAS CLAVE: Baldomero Espartero, carisma, Isabel II, regencia, 1840   ABSTRACT The 1840 September Revolution ended when Fernando VII’s widow, María Cristina de Borbón, abdicated and Baldomero Espartero from Manchego came to power. A few months later, he became the sole Regent for more than two years, until his final fall and exile in London. In this process of pressure over Isabel II’s mother, as well as the signing of the restrictive City Halls Law, admiration of the hero of Luchana among the lower classes played a crucial role. The aim of this text is to discover why from the Carlist War it was believed that Espartero would be able to guarantee the liberties established by the 1837 Constitution against obstacles and abuses set by María Cristina and her acolytes. Towards this goal, the study of primary sources (press, parliamentary debates) is combined with the most recent works on this topic.   KEY WORDS: Baldomero Espartero, charisma, Isabel II, Regency, 1840
El ritmo cotidiano de la vida en el monasterio medieval
Authors: García Carpintero Jaime
Published: July 2017

Reseña de la obra mencionada.
Las Navas de Tolosa. 1212-2012. Miradas cruzadas
Authors: Gallego Valle David
Published: July 2017

Reseña de la obra mencionada.
La agonía de la República. El final de la guerra civil española (1938-1939)
Authors: Gargallo Vaamonde Luis
Published: July 2017

Reseña de la obra mencionada.
Asociacionismo en Palencia durante el franquismo
Authors: Alía Miranda Francisco
Published: July 2017

Reseña de la obra mencionada.