bluuebunny/crossref_metadata_2025 huggingface dataset:
ANTAGONISTIC ACTINOBACTERIAL DIVERSITY OF MARINE SEDIMENTS COLLECTED FROM COASTAL TAMIL NADU
Authors: Madheslu Manikandan , Mani Swapna , Kasiviswanathan Duraimurugan , Prabagaran Solai Ramatchandirane
Published: January 2019

Objective: The main objective of the current investigation is to identify the antagonistic potential of marine sediment actinobacterial population collected from coastal regions of Tamil Nadu and Kerala.Methods: A total of 60 marine sediment samples were collected from 27 locations of coastal Tamil Nadu and Kerala. A total of 85 morphologically distinct actinobacterial strains were isolated and taxonomically characterized. The strains were screened for its antagonistic potential against selected bacteria strains, and the obtained results were statistically analyzed. Further, the strains excelled in producing antimicrobial substances were subjected to electron microscopic and chemotaxonomic studies to get more taxonomic details.Results: The isolates were identified as different species of Streptomyces, Micromonospora, Saccharopolyspora, Actinopolyspora, Nocardia, Nocardioides, Kitasatospora, and the rest of them were categorized as “unidentified.” All the isolates were subjected to antimicrobial assay through cross-streak and well diffusion methods that endorsed 34 (40%) of them to be active against clinical and reference bacterial strains such as Staphylococcus aureus MTCC 3160, S. aureus (methicillin-resistant), Bacillus pumilus NCIM 2327, Escherichia coli MTCC 1698, E. coli, Shigella flexneri MTCC 1457, and Proteus vulgaris. The predominance of Streptomyces (18) was ascertained and followed by Saccharopolyspora (7), Micromonospora (5), Nocardia (2), and Kitasatospora (2) with considerable antimicrobial activities. Statistical analysis revealed that the isolates BDK01, BMT01, BPY03, and BRS07 showed significant antimicrobial activities. Phenotypic and chemotaxonomic analysis revealed that all four isolates are belonging under Streptomyces genus.Conclusion: The output of the present investigation revealed that the Streptomyces species are predominant in marine sediments and gain more attention for their antagonistic potential. Therefore, assessment and evaluation of marine microbial diversity were done, which could serve as a potential source for novel antibiotics.
PREPARATION OF MUCOADHESIVE GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALGINATE BEADS CONTAINING TURMERIC EXTRACT AND ANTI-GASTRIC ULCER ACTIVITY
Authors: Bangun Hakim , Aulia Fadlina , Arianto Anayanti , Nainggolan Marline
Published: January 2019

Objectives: The objectives of this study were to prepare the mucoadhesive mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract and to evaluate its anti-gastric effect.Methods: Turmeric extract was made by macerating turmeric powder in ethanol 96% and evaporated using rotary evaporator at 50°C to obtained concentrated extract. Then, it was prepared alginate beads containing 5% turmeric extract by gelation method. The mucoadhesive properties of alginate beads containing turmeric extract were tested in vitro in male rats and the anti-gastric ulcer effect was tested on HCl-induced gastric ulcer in rats.Results: The mean diameter of alginate beads obtained was 1.13±0.19 mm. Bioadhesion test showed that alginate beads containing turmeric extract could be attached on gastric rats mucosa. Anti-gastric ulcer test showed that the healing of gastric lesions in rats was faster using alginate beads containing turmeric extract compared to untreated ones.Conclusions: The results of this study suggest that mucoadhesive drug delivery systems of alginate beads containing turmeric extract are potentially developed as an anti-gastric ulcer.
PREPARATION AND EVALUATION OF ULTRASOUND TRANSMISSION GEL
Authors: Al-nima Amina M , Al-kotaji Myasar , Al-iraqi Osamah , H Ali Zahraa
Published: January 2019

Objective: Formulation of an alternative ultrasound transmission gel that is of good quality using the available chemicals in Iraqi market and without any harmful effects to skin. Methods: Four formulas G1, G2, G3, and G4 with different Carbopol 934 concentrations (0.3, 0.4, 0.5, and 0.6) w/v%, respectively, were prepared and evaluated for different physicochemical characteristics including: Clarity, homogeneity, density, pH, viscosity, and spreadability tests. Other evaluations including skin irritation, microbiological, and stability tests were also performed for the selected formula along with a comparison study with the commercially available ultrasound gel (commercial gel [CG]) which was used as a control. In addition, transmission test was carried out by comparing the transmission between (CG) and (G1) with the assistance of three veterinary radiologists who did ultrasonography of bovine liver for 11 adult cattle breed, aged 3–8 years. The three veterinary radiologists were given 33 data sheets to collect results.Results: Among all the prepared formulas (G1), the formula was considered the best, due to its high clarity, very good homogeneity; its pH was equal to 6.8 which is near to skin pH. Other parameters such as density, viscosity, torque percent, and spreadability showed no significant difference (p≤0.05) with CG. Skin irritation test which was conducted on animals and humans showed no any adverse effects on skin. Microbiological test manifested that using methylparaben alone was sufficient to prevent the growth of microbes in the gel. The three veterinary radiologists found no significant difference (p≤0.05) between G1 and CG formulations. Stability study indicated that the gel was stable after storage at room temperature for 3 months.Conclusion: The overall results suggest that the selected formula (G1) can be considered a successful ultrasound gel and can be used as a good and cheap alternative of the marketed imported gel.
THE CYTOPROTECTIVE ACTIVITY OF AQUEOUS GREEN TEA EXTRACT AGAINST METRONIDAZOLE AND TINIDAZOLE GENOTOXIC EFFECT
Authors: Hassan Ali Faris , Kahtan Mahmood , Al-shawi Nada Naje , Numan Intesar Tareq , Bahader Ghaith Abbas
Published: January 2019

Objective: The study was designed to evaluate the genoprotective effect of green tea extract against genotoxicity induced by metronidazole and tinidazole.Methods: A total of 36 mice were used, for each experiment. The animals were allocated into six groups: Group I - negative control administered distilled water; Group II - healthy mice treated with metronidazole alone, Group III - healthy mice treated with tinidazole alone, Group IV - healthy mice administered green tea extract alone, Group V - healthy mice administered of metronidazole anddd then green tea extract was administered, and Group VI - healthy mice administered of tinidazole and then green tea extract was administered.Results: It has been found that there are significant differences in mitotic index and micronucleus (MN) appearance between the Groups II, IV, and V (7.76±0.8, 11.92±1.14, and 8.36±0.57 and 6.92±0.5, 10.18±1.19, and 7.52±1.05) in bone marrow cells and spleen cells for mitotic index, respectively (6.75±0.4, 5.5±0.41, and 5.92±0.68), in bone marrow for MN appearance. Furthermore, it has been found that there are significant differences in mitotic index and MN appearance between the Groups III, IV, and VI (4.36±0.88, 11.92±1.14, and 5.36±0.55 and 4.08±0.35, 10.18±1.19, and 5.08±0.35) in bone marrow cells and spleen cells for mitotic index, respectively (8.43±0.96, 5.5±0.41, and 6.84±0.66), in bone marrow for MN appearance.Conclusion: The aqueous extract of green tea has a protective effect against the genotoxic effects induced by either metronidazole or tinidazole in mice.
ANTIFIBROTIC ACTIVITY OF MESNA AGAINST AMIODARONE-ASSOCIATED LUNG INJURY IN WISTAR RATS
Authors: Razzaq Mshimesh Bahir Abdul
Published: January 2019

Objective: Lung fibrosis is a progressive respiratory disease with a high percentage of mortality. Till now, it had bad prognosis to conventional medications. This study was designed to evaluate the role of mesna, the well-known antioxidant agent, against pulmonary fibrosis.Methods: Pulmonary fibrosis was induced by administration of amiodarone to Wistar rats. Lung indices, leukocytes count, oxidative stress markers, cytokines levels, and hydroxyproline contents, in addition to the histopathological tests, were done for control, amiodarone, and mesna plus amiodarone group.Results: The elevated ratio of lung/body weight and total leukocytes count within bronchoalveolar lavage fluid for amiodarone rats was decline significantly when cotreated with mesna therapy. Furthermore, mesna significantly brought down the lipid peroxidation of amiodarone in lung tissue, represented by decreasing malondialdehyde level and increasing superoxide dismutase (SOD) and catalase activity. In addition, mesna diminished the profibrotic transforming growth factor-β1 level while elevated the antifibrotic interferon-γ level, and the high activity of the enzyme matrix metalloproteinase-7 was restored within mesna group. Meanwhile, mesna counteracts the increment of hydroxyproline contents and Ashcroft grading scale within amiodarone group. Histologically, critical improvement in the inflammatory cell penetration and alveolar septa was seen in the lung tissue of rats within mesna group, contrasted with those received just amiodarone. Trichome staining clarified that collagen deposition was notably diminished in the peri-alveolar and peri-bronchial area within mesna group. Moreover, mesna therapy downregulated SMAD3 protein level, which was overexpressed by amiodarone challenge.Conclusion: This study gives evidence that mesna therapy may act as a protective agent against amiodarone-mediated pulmonary fibrosis.
EVALUATION OF ANTIBACTERIAL, ANTIMICROBIAL, AND HYPOGLYCEMIC EFFECTS OF THE LEAVES OF EMBELIA RIBES
Authors: Banu H Haseena , Ms Prateeba , Loganathan Preethi , Subramaniam Suganthi
Published: January 2019

Objective: The purpose of this work is to evaluate the antimicrobial, antibacterial, and hypoglycemic effects of methanolic and ethanolic extracts of Embelia ribes leaves using in vitro studies.Methods: Antibacterial activities of the methanolic and ethanolic extract of E. ribes leaves against Escherichia coli, Staphylococcus aureus, Enterococci, and Klebsiella pneumoniae at different concentrations ranging from 10, 25, 50, and 75 μg/mL and their antibacterial activities were compared to those of the reference controls such as ciprofloxacin and clindamycin. Furthermore, the effect of leaf extracts on α-amylase and α-glucosidase enzymes was assayed.Results: The methanolic and ethanolic extract of E. ribes leaves effectively inhibited the activity of α-amylase and α-glucosidase in a dose-dependent manner. The effect of the methanolic extract was more prominent than that of ethanolic extract. At the same time, both the extracts showed markable inhibition of bacterial growth at a concentration of 75 μg/mL compared to the other three doses (10, 25, and 50 μg/ml) and also commercially available antibiotic drugs ciprofloxacin and clindamycin that were used as positive control drugs. The antibacterial activity of methanolic extract is significantly higher than that of ethanolic extract.Conclusion: The preliminary results of this study have put forward E. ribes into promising herb with respect to its therapeutic potential although further studies are needed to evaluate its mechanism of action.
Revista Enfermería Universitaria ENEO-UNAM
Authors: Salazar Gómez Teresa
Published: January 2019

Revista Enfermería Universitaria ENEO-UNAM
Caracterización de la población usuaria que ingresa al programa interrupción legal del embarazo en un hospital del sector salud del DF
Authors: Bernal Becerril Martha Lilia , Hernández Ruiz Yoali Yeyetlzi , Mercader Arroyo Fernanda , Guerrero Labastida Alma Teresa , Ponce Gómez Gandhy
Published: January 2019

Introducción: El embarazo no deseado, lleva a la mujer a practicarse un aborto. De acuerdo a International Projects Assistance Services (IPAS) en México, el aborto y sus complicaciones son la 5ª causa de muerte materna. En el D.F. la despenalización de la interrupción del embarazo antes de las 12 semanas de gestación es una ley, lo que ha significado derecho a elegir voluntaria y libremente sobre la maternidad y por lo tanto a decidir la interrupción de un embarazo. Objetivo: Caracterizar a la población que acude al programa de Interrupción Legal del Embarazo (ILE) en un hospital del sector salud del D.F. Metodología: Estudio cuantitativo, descriptivo y transversal, encuestando a 61 mujeres, que deseaban ingresar al programa ILE y aceptaron participar en el estudio. Se realizó y aplicó un instrumento de valoración con 27 ítems. Resultados: Mujeres asistentes al ILE de entre 16 y 42 años; el 46% se dedican al hogar; 50% solteras y el resto en unión libre o casadas; el 23% reportó no emplear ningún método para control de la natalidad. Principales razones para acudir al programa ILE: problemas económicos (36%), embarazo no deseado (20%), paridad satisfecha (20%). Principal sentimiento que despierta el ingreso al programa ILE: tranquilidad (82%). El 100% de las mujeres sometidas a ILE aseguran haber sido tratadas con ética y dignidad. Discusión: Se concuerda con Gutmacher que la legalización de la interrupción del embarazo coincide con el incremento en solicitudes de la mujer a este procedimiento. Respecto a las razones tales como embarazo no deseado y los problemas económicos, ello corresponde con los resultados de la encuesta IPSOS- Bimsa para Population Council en la población Mexicana. Conclusiones. Debe ser creciente la calidad de atención a la salud reproductiva, se debe priorizar en la prevención de embarazos no deseados, orientando y educando a la población y ofreciendo métodos de planificación a hombres y mujeres con vida sexual activa.
¿Para qué estudiar el síndrome de burnout en el personal de enfermería en México? Precisiones metodológicas para el desarrollo de una línea de investigación
Authors: Fernández García Victoria , Zarate Grajales Rosa A. , Lartigue Becerra Teresa
Published: January 2019

Introducción: Diversos estudios internacionales buscan determinar la contribución del estrés laboral al problema de la escasez de enfermeras y sus efectos en la calidad del paciente. En México existe poca información sobre la magnitud del estrés laboral en enfermeras y la diversidad de metodologías y criterios utilizados para medirlo dificulta la comparación en distintos contextos nacionales. A partir de la revisión de las publicaciones nacionales, en este trabajo se discuten aspectos conceptuales y metodológicos para aproximarse al estudio del SB, con la finalidad de definir una línea de investigación que corresponda a la realidad de la práctica profesional en nuestro país. Desarrollo: Se revisa el concepto central de estrés laboral, el instrumento y los aspectos críticos para determinar la prevalencia, las teorías y modelos desarrollados en el estudio del SB, así como los diferentes niveles de análisis y relaciones a estudiar dentro del modelo del clima organizacional. Conclusiones. Es necesario desarrollar líneas de investigación utilizando un instrumento que permita la comparación y estableciendo claramente las bases teóricas subyacentes en el análisis de las relaciones del SB con las diferentes variables. Asimismo, se requiere información sobre las características organizacionales de los hospitales o unidades de salud en las que se generan las prevalencias reportadas, así como los coeficientes pacientes/enfermera relacionadas con las mismas y preferentemente, incluir una variable de resultado en la salud del paciente, de la enfermera o de la organización De esta manera sería posible conocer la prevalencia de SB, los factores asociados a su origen, a sus efectos y posibles soluciones.
Memorias de la Escuela Nacional de Enfermería y Obstetricia ENEO-UNAM
Authors: Perez Cabrera Iñiga
Published: January 2019

Memorias de la Escuela Nacional de Enfermería y Obstetricia ENEO-UNAM.
Enfoque constructivista en el aprendizaje de la asignatura de metodología de la investigación en la ENEO.
Authors: Salcedo Álvarez Rey Arturo , Alba Leonel Adela , Zarza Arizmendi María Dolores
Published: January 2019

Introducción: El aprendizaje de la investigación en enfermería generalmente se realiza a través de una educación de tipo tradicional. La enseñanza con enfoque constructivista favorecen el aprendizaje significativo y la innovación de la práctica investigativa de los problemas inherentes al cuidado. Objetivo: Realizar un diagnóstico sobre la aplicación del enfoque constructivista en el aprendizaje de la asignatura de metodología de la investigación. Metodología: Estudio de investigación educativa de tipo transversal realizado a través de una encuesta donde se exploraron cinco áreas sobre la aplicación del enfoque constructivista en el aprendizaje de la asignatura de metodología de la investigación. Resultados: Durante la primera semana de diciembre de 2008, se aplicaron 116 encuestas; el análisis de ellas, mostró que la distribución percentilar del indicador de puntuación general para el aprendizaje constructivista acumulo las frecuencias más altas para las respuestas de "casi siempre" percentil 0.25 (42), mediana (48) y percentil 0.75 (54); para la respuesta "siempre" percentil 0.25 (44), mediana (49) y percentil 0.75 (51). Discusión: Acorde a la literatura la concepción constructivista implica, la disposición total por parte del alumno y la guía del profesor en la dinámica de la enseñanza misma que si se dio en la enseñanza de esta asignatura. Conclusiones: De acuerdo con los resultados, los docentes de los grupos estudiados que imparten la asignatura de metodología de la investigación si utilizan un enfoque de constructivista.
Patrones locales de alimentación del león marino sudamericano Otaria byronia: el caso de Punta Patache, Norte de Chile
Authors: Sielfeld Walter , Barraza Jorge , Amado Nelson
Published: January 2019

Mediante análisis de fecas se estudiaron los hábitos alimentarios del león marino sudamericano (Otaria byronia) (LMS) en Punta Patache, norte de Chile durante 2 periodos El Niño (1997/98 y 2009/10). Las muestras fecales (n= 183) fueron colectadas en la lobera de Punta Patache, sur de Iquique (20º48’63’’S). Se identificaron 10 especies de presas neríticas (incluyendo 4 peces, 2 cefalópodos y 3 crustáceos). Los más importantes para el conjunto de ambos períodos fueron en términos de abundancia la anchoveta (Engraulis ringens) (7,4%), el langostino (Pleuroncodes monodon) (83,0%) y el calamar (Loligo gahi) (6,9%). En términos de biomasa consumida destacaron el calamar (35,7%) y el langostino (21,9%). En términos de aportes energéticos a la dieta, los más importantes fueron el langostino (19,9-32,7%) y el calamar (24,9-40,5%), en lípidos la anchoveta (31,8-36,4%) y en proteína el calamar (20,9-41,0%) y el langostino (22,5-29,9%). La comparación con resultados de estudios anteriores bajo condiciones ENOS neutrales/frías (1996 y 2015) destaca mayor consumo de anchoveta (82,8% y 23,3-48,4%, respectivamente). Sobre esta base se concluye que frente a la falta de anchoveta durante el desarrollo de eventos ENOS, el LMS ajustaría su dieta a otros recursos, situación que determina un ‘estrés nutricional’ derivado de una nutrición inadecuada, cuyas consecuencias son reducción del crecimiento, bajas en la tasa de natalidad, enfermedades, desnutrición y en muchos casos muerte, tal como se ha reportado para los ENOS fuertes 1982/83 y 1997/98.
Potencial de microalgas bentónicas del Mar Caribe como alimento en maricultura
Authors: Carrera Silvia , Velasco Luz Adriana , Barreto-Hernández Alix
Published: January 2019

Para el desarrollo de la acuicultura marina en el Caribe es deseable la disponibilidad de microalgas bentónicas locales como alimento. En este trabajo, se aislaron seis cepas de microalgas bentónicas y se evaluó su potencial para utilizarlas en acuicultura mediante el análisis de su tamaño, densidad celular, tasa de crecimiento, composición proximal, así como su capacidad para producir biomasa sobre placas bajo condiciones de cultivo bajo techo y en exterior. Se aislaron y describieron tres diatomeas (Cylindrotheca closterium, Entomoneis alata y Plagiotropis lepidoptera), dos cianobacterias (Komvophoron crassum y Synechococcus sp.) y una clorófita (Tetraselmis chuii). Las cianobacterias presentaron los menores tamaños celulares, mientras que las diatomeas los mayores. Bajo condiciones de cultivo planctónico, la mayor densidad algal la presentó Synechococcus sp., mientras que la mayor tasa de crecimiento ocurrió en E. alata. Mayores contenidos de proteínas y relación proteínas/energía se presentaron en las diatomeas, los de carbohidratos en Tetraselmis chuii y las cianobacterias, mientras que los de lípidos y energía se registraron en las diatomeas E. alata y P. lepidoptera. Bajo condiciones de cultivo bentónico, la mayor producción de biomasa y tasa crecimiento se obtuvo en las cianobacterias y en P. lepidoptera. La mayoría de las microalgas exhibieron mayores valores de biomasa asentada en condiciones bajo techo y en exterior, así como similares tasas de crecimiento en los dos sitios. En conclusión, dado el tamaño, composición proximal, biomasa asentada y tasa crecimiento, todas las microalgas bentónicas aisladas tienen el mismo potencial para ser usadas como alimento en acuicultura marina.
Preliminary analysis of the feeding habits of batoids from the genera Mobula and Myliobatis in Northern Peru
Authors: Coasaca-Céspedes Javier Jesús , Segura-Cobeña Eduardo , Montero-Taboada Rebeca , Gonzalez-Pestana Adriana , Alfaro-Córdova Eliana , Alfaro-Shigueto Joanna , Mangel Jeffrey C.
Published: January 2019

Abstract.- This study provides baseline information on the feeding habits of five batoid species from the genera Mobula and Myliobatis sampled from the small-scale driftnet fishery in northern Peru. The diets of Mobula mobular, Mobula munkiana and Mobula thurstoni consisted mainly of euphausiids. Dietary niche breadth indicated a pelagic feeding behaviour of a specialist and a trophic level of a secondary predator for both M. mobular and M. munkiana. In contrast, Myliobatis chilensis and Myliobatis peruvianus consumed mostly gastropods and crustaceans. Dietary niche breadth indicated a feeding behaviour of a benthic specialist and a trophic level of a secondary predator for Myliobatis chilensis.
Review of reports of the IFPA annual meeting “Placenta: Back to the Basics” (September 13-16th, 2016, Portland, USA)
Authors: Kyryk V.
Published: January 2019

Review of reports of the IFPA annual meeting “Placenta: Back to the Basics” (September 13-16th, 2016, Portland, USA)
Prevalencia de migraña y análisis de factores asociados en estudiantes de medicina colombianos
Authors: Salazar Espinosa Juan Felipe , Cardona Ramírez Jhojan Danilo , Perez Agudelo Juan Manuel
Published: January 2019

RESUMEN

Objetivo: Determinar la prevalencia de migraña en estudiantes de medicina colombianos y su correlación con variables sociodemográficas y clínicas. Materiales y métodos: Estudio descriptivo y transversal, desarrollado en 49 universidades colombianas. Se incluyeron 299 estudiantes de medicina de primer a decimotercer semestre. Se aplicó un instrumento que contenía el autocuestionario validado ALCOI-95. Resultados: 69,6% de los sujetos fueron mujeres. La media de edad fue de 20,6 años. El 17,1% cursaba V semestre. La prevalencia de cefalea fue de 97,7% y la prevalencia de migraña de 72,5%, predominando en las mujeres (71,9%), la prevalencia fue mayor en III, V y VIII semestre, existiendo una diferencia estadísticamente significativa. No se encontró una relación estadísticamente significativa entre las variables evaluadas y los criterios ALCOI-95. Conclusión: El presente estudio resalta la elevada prevalencia de migraña en los estudiantes de medicina colombianos y la frecuencia de factores relacionados coexistentes como consumo de alcohol, tabaquismo y estrés psicológico.

Palabras Clave: Trastornos Migrañosos; Estudiantes de medicina; Migraña con Aura.
REMASTERING LIVE USB UNTUK �LAMP� PADA FAKULTAS SAINS DAN TEKNOLOGI PALEMBANG
Authors: B.S. Klaudius Jevanda
Published: January 2019

ABSTRAK Penelitian ini bertujuan untuk membuat distribusi Linux bernama Lubuntu yang memfokuskan diri pada desktop yang ringan serta ditujukan untuk menjadi lingkungan web server yang free dalam bentuk live USB. Dimana, penelitian ini menjelaskan tentang desain dan implementasi dari distribusi Linux Lubuntu itu sendiri yang nantinya bisa terus diperbaiki, disempurnakan dan dimungkinkan untuk dimodifikasi serta dipelajari oleh pihak lain. Lubuntu dikembangkan dengan memodifikasi dari Linux Lubuntu 14.04 dari tahap penambahan program, penghapusan program dan konfigurasi sampai pada tahap pembuatan Live USB untuk LAMP (Linux Apache Mysql PHP) menggunakan metode remastering. Hasil dari penelitian ini berupa Live USB yang berisi tool untuk lingkungan web server. Tool utama dalam Live USB diantaranya adalah phpmyadmin, gimp, inkscape, dan bluefish. Keluaran penelitian ini, diharapkan bisa digunakan sebagai sistem operasi dan dikhususkan dalam lingkungan web server yang nyaman untuk dipergunakan dalam proses belajar mengajar pada matakuliah sistem operasi, pemrograman basis web I, dan pemrograman basis web II di Fakultas Sains dan Teknologi Universitas Katolik Musi Charitas palembang. Kata kunci: linux, web server, LAMP, remastering, live usb.
ALGORITMA NAIVE BAYES DENGAN FITUR SELEKSI UNTUK MENGETAHUI HUBUNGAN VARIABEL NILAI DAN LATAR BELAKANG PENDIDIKAN
Authors: Astuti Yani Parti , Sudibyo Usman , Kurniawan Achmad Wahid , Rahayu Yuniarsi
Published: January 2019

Setiap Perguruan Tinggi mempunyai mahasiswa baru yang berasal dari berbagai sekolah menengah atas dan juga sekolah menengah kejuruan. Seperti halnya pada program studi teknik informatika fakultas ilmu komputer di Universitas Dian Nuswantoro. Program studi ini mempunyai mahasiswa terbanyak di Udinus, sehingga perlu selalu diadakan evaluasi. Dalam hal ini evaluasi yang dipilih adalah tentang asal jurusan sekolah mahasiswa dengan variabel nilai mata kuliah. Dengan mengambil mahasiswa dari angkatan tahun 2010 sampai 2012 sebanyak 10030 mahasiswa, hanya 489 mahasiswa yang mengisi asal jurusan sekolah. Dari sejumlah mahasiswa tersebut dilakukan preposisi dengan mengambil nilai mata kuliah wajib sebanyak 25 mata kuliah dan asal jurusan sekolah. Teknik data mining berupa algoritma naive bayes dioptimasi dengan fitur selesi forward selection telah meningkatkan akurasi dalam penemuan pola klasifikasi. Peningkatan akurasi dari naive bayes 64,77% menjadi 78,08% setelah dioptimasi dengan forward selection. Dengan demikian hasil klasifikasi tersebut bisa digunakan sebagai informasi dalam metode pembelajaran yang bisa diterapkan.Kata kunci: data mining, forward selection, naïve bayes.
PERANCANGAN E-MARKETING UMKM KERAJINAN TAS
Authors: Susanti Nanik
Published: January 2019

Perkembangan teknologi, dunia digital dan internet berdampak kuat pada dunia pemasaran. Diciptakannya teknologi e-marketing sebagai salah satu strategi pemasaran yang mampu menjangkau jaringan masyarakat luas. Perancangan e-marketing dalam penelitian ini ditujukan kepada usaha mikro, kecil dan menengah pengrajin tas yang tergabung dalam KUB Valya Bags di Desa Gulang. Permasalahan yang dihadapi oleh para pengrajin adalah minimnya strategi pengembangan usaha, masih menggunakan sistem traditional marketing. Jangkauan pasar sempit, Keterbatasan media promosi serta keluhan calon pembeli yang merasa kesulitan untuk mengetahui detail produk tas. Metode penelitian yang dilakukan dengan menganalisa kebutuhan yang dapat menghasilkan pemodelan sistem pemasaran dengan menggunakan perancangan sistem UML. Penelitian ini menghasilkan sebuah analisa dan perancangan e- marketing bagi UMKM pengrajin Tas di Desa Gulang yang diharapkan mampu menjangkau pasar yang lebih luas, jumlah konsumen meningkat serta dapat menjalin hubungan interaksi penjual dan pembeli tanpa dibatasi ruang dan waktu yang pada akhirnya dapat  meningkatkan perekonomian masyarakat khusunya para pengrajin tas. Sistem yang dibangun meghasilkan aplikasi website untuk pemasaran produk tas yang diproduksi oleh KUB Valya Bags. Aplikasi website dapat diakses melalui URL http://www.valyabags.online. Kata kunci: strategi pemasaran, e-marketing, kerajinan tas.
FINTECH SEBAGAI SALAH SATU SOLUSI PEMBIAYAAN BAGI UMKM
Authors: Rizal Muhamad , Maulina Erna , Kostini Nenden
Published: January 2019

ABSTRACTIn 2017, more than 40 new fintech businesses is born, this financial business have emerged that have tried their luck in the Indonesian financial landscape along with the other 140s of startup that have stood before. Indonesia's fintech industry has become one of the prima donna that attracted so much attention from the financial industry actors. Investment on startup fintech began to attract a lot of interest, even some startup managed to get series A of investment this year. The fintech sectors are beginning to develop and many new products are launched.Meanwhile, the Ministry of Cooperatives and Small and Medium Enterprises (Ministry of Small and Medium Enterprises) launched 3.79 million micro, small and medium enterprises (SMEs) already utilizing online platform in marketing their products. This number is around 8 percent of the total perpetrators of SMEs in Indonesia, which is 59.2 million.The problem of sources of financing is a classic problem that is a barrier to the growth of SMEs who do not get financing facilities from the banking sector. Lack of financial resources makes SMEs unable to develop innovations to increase production. However, the rapid growth of financing business of fintech, such as peer-to-peer lending can now be another alternative for loan fund raisers. peer-to-peer lending is a financing business that targets the middle to lower market sectors  ABSTRAKSepanjang tahun 2017, setidaknya muncul lebih dari 40 bisnis fintech baru yang mencoba peruntungan di lanskap keuangan Indonesia bersama dengan 140-an startup lain yang telah berdiri sebelumnya. Industri fintech Indonesia memang menjadi salah satu primadona yang menarik perhatian begitu besar dari para pelaku industri keuangan. Investasi pada startup fintech mulai banyak diminati, bahkan beberapa startup berhasil mendapatkan investasi seri A di tahun ini. Sektor-sektor fintech mulai berkembang dan produk-produk baru banyak diluncurkan.Sementara itu, Kementerian Koperasi dan Usaha Kecil Menengah (Kemenkop UKM) melansir sebanyak 3,79 juta usaha mikro, kecil, dan menengah (UMKM) sudah memanfaatkan platform online dalam memasarkan produknya. Jumlah ini berkisar 8 persen dari total pelaku UMKM yang ada di Indonesia, yakni 59,2 juta.Masalah sumber pembiayaan merupakan masalah klasik yang menjadi penghambat pertumbuhan UMKM yang tidak mendapat fasilitas pembiayaan dari sektor perbankan. Kurangnya sumber dana menjadikan UMKM tidak dapat mengembangkan inovasi untuk meningkatkan produksinya. Namun demikian pesatnya pertumbuhan bisnis pembiayaan FinTech seperti peer-to-peer lending  sekarang ini bisa menjadi alternatif lain bagi para pencari dana pinjaman. peer-to-peer lending merupakan bisnis pembiayaan yang menyasar sektor  pasar menengah ke bawah.
Praćenje vršnog ekspiratornog protoka u dijagnozi profesionalne astme
Authors: Skroza Dina , Macan Jelena
Published: January 2019

Prema podacima iz Registra profesionalnih bolesti Hrvatskoga zavoda za zaštitu zdravlja i sigurnost na radu, u posljednjih deset godina (2008. ‒ 2017.) prijavljeno je samo 20 slučajeva profesionalne astme od ukupno 2234 prijavljene profesionalne bolesti. To upućuje na značajne nedostatke u prepoznavanju toga poremećaja u našoj radnoj populaciji. Cilj ovoga rada bio je opisati standardnu metodu praćenja vršnog ekspiratornog protoka zraka (eng. peak expiratory flow, PEF) i predložiti praktičnu smjernicu za korištenje te dijagnostičke metode u ambulantama medicine rada i sporta. Praćenje vršnog ekspiratornog protoka zraka (PEF-monitoring) jednostavna je, jeftina, neinvazivna i pouzdana metoda za utvrđivanje funkcije dišnog sustava u stvarnim uvjetima rada i radnog okoliša. Sadašnje smjernice preporučuju PEF-monitoring kao inicijalnu dijagnostičku metodu prilikom sumnje na profesionalnu astmu. Pozitivan test upozorava na povezanost promjene plućne funkcije s radnom izloženošću i važan je dio dijagnostičkoga procesa utvrđivanja profesionalne astme. Najveći je nedostatak te metode da se tim testom ne može utvrditi uzrok astme, tj. on ne razlikuje profesionalnu astmu od astme pogoršane na radu, nema standardizirane metode za interpretaciju rezultata, a mjerenja provode sami radnici pa su moguće namjerne i nenamjerne manipulacije rezultatima mjerenja. U radu je predložena praktična smjernica za primjenu te metode u ambulantama medicine rada i sporta, s preporukama protokola mjerenja PEF-a, prikaza rezultata mjerenja i njihove interpretacije u sklopu dijagnosticiranja profesionalne astme.
Sodium-glucose cotransporters: new targets of cancer therapy?
Authors: Madunić Ivana Vrhovac , Madunić Josip , Breljak Davorka , Karaica Dean , Sabolić Ivan
Published: January 2019

Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium-glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. As the current standard positron emission tomography (PET) tracer 2-deoxy-2-(18F)fluoro-D-glucose (2-FDG) for imaging tumour cells via GLUT1 lacks in sensitivity and specificity, it may soon be replaced by the newly designed, highly sensitive and specific SGLT tracer α-methyl-4-(F-18)fluoro-4-deoxy-Dglucopyranoside (Me-4FDG) in clinical detection and tumour staging. This tracer has recently demonstrated the functional activity of SGLT in pancreatic, prostate, and brain cancers. The mRNA and protein expression of SGLTs have also been reported in colon/colorectal, lung, ovarian, head, neck, and oral squamous carcinomas. So far, SGLTs have been poorly investigated in cancer, and their protein expression and localisation are often controversial due to a lack of specific SGLT antibodies. In this review, we describe current knowledge concerning SGLT1 and SGLT2 (over)expression in various cancer types. The findings of SGLTs in malignant cells may help in developing novel cancer therapies with SGLT2 or SGLT1/SGLT2 inhibitors already used in diabetes mellitus treatment.
Insert a Root to Extract a Root of Quintic Quickly
Authors: Kulkarni Raghavendra G.
Published: January 2019

The usual way of solving a solvable quintic equation has been to establish more equations than unknowns, so that some relation among the coefficients comes up, leading to the solutions. In this paper, a relation among the coefficients of a principal quintic equation is established by effecting a change of variable and inserting a root to the quintic equation, and then equating odd-powers of the resulting sextic equation to zero. This leads to an even-powered sextic equation, or equivalently a cubic equation; thus one needs to solve the cubic equation.

We break from this tradition, rather factor the even-powered sextic equation in a novel fashion, such that the inserted root is identified quickly along with one root of the quintic equation in a quadratic factor of the form, u
2
− g
2 = (u + g)(u − g). Thus there is no need to solve any cubic equation. As an extra benefit, this root is a function of only one coefficient of the given quintic equation.
Three-dimensional pulmonary monitoring using focused electrical impedance measurements
Authors: Orschulik Jakob , Pokee Diana , Menden Tobias , Leonhardt Steffen , Walter Marian
Published: January 2019

Lung pathologies such as edema, atelectasis or pneumonia are potentially life threatening conditions. Especially in critically ill and mechanically ventilated patients, an early diagnosis and treatment is crucial to prevent an Acute Respiratory Distress Syndrome [1]. Thus, continuous monitoring tool for the lung condition available at the bedside would be highly appreciated. One concept for this is Electrical Impedance Tomography (EIT). In EIT, an electrode belt of typically 16 or 32 electrodes is attached at the body surface and multiple impedance measurements are performed. From this, the conductivity change inside the body is reconstructed in a two-dimensional image. In various studies, EIT proved to be a useful tool for quantifying recruitment maneuvers, the assessment of the ventilation homogeneity, the detection of lung edema or perfusion monitoring [2, 3, 4, 5]. Nevertheless, the main problem of EIT is the low spatial resolution (compared to CT) and the limitation to two dimensional images. In this paper, we try to address the latter issue: Instead of projecting conductivity changes onto a two-dimensional image, we adjust electrode positions to focus single tetrapolar measurements to specific, three-dimensional regions of interest. In earlier work, we defined guidelines to achieve this focusing [6, 7]. In this paper, we demonstrate in simulations and in a water tank experiment that applying these guidelines can help to detect pathologies in specific lung regions.
A single differential equation description of membrane properties underlying the action potential and the axon electric field
Authors: Melendy Robert F.
Published: January 2019

In a succession of articles published over 65 years ago, Sir Alan Lloyd Hodgkin and Sir Andrew Fielding Huxley established what now forms our physical understanding of excitation in nerve, and how the axon conducts the action potential. They uniquely quantified the movement of ions in the nerve cell during the action potential, and demonstrated that the action potential is the result of a depolarizing event across the cell membrane. They confirmed that a complete depolarization event is followed by an abrupt increase in voltage that propagates longitudinally along the axon, accompanied by considerable increases in membrane conductance. In an elegant theoretical framework, they rigorously described fundamental properties of the Na+ and K+ conductances intrinsic to the action potential.

Notwithstanding the elegance of Hodgkin and Huxley’s incisive and explicative series of discoveries, their model is mathematically complex, relies on no small number of stochastic factors, and has no analytical solution. Solving for the membrane action potential and the ionic currents requires integrations approximated using numerical methods. In this article I present an analytical formalism of the nerve action potential, Vm
and that of the accompanying cell membrane electric field, Em
. To conclude, I present a novel description of Vm
in terms of a single, nonlinear differential equation. This is an original stand-alone article: the major contribution is the latter, and how this description coincides with the cell membrane electric field. This work has necessitated unifying information from two preceding papers [1,2], each being concerned with the development of closed-form descriptions of the nerve action potential, Vm
.
Measurement of cerebral blood flow autoregulation with rheoencephalography: a comparative pig study
Authors: Bodo Michael , D. Montgomery Leslie , J. Pearce Frederick , Armonda Rocco
Published: January 2019

Neuromonitoring is performed to prevent further (secondary) brain damage by detecting low brain blood flow following a head injury, stroke or neurosurgery. This comparative neuromonitoring study is part of an ongoing investigation of brain bioimpedance (rheoencephalography-REG) as a measuring modality for use in both civilian and military medical settings, such as patient transport, emergency care and neurosurgery intensive care. In a previous animal study, we validated that REG detects cerebral blood flow autoregulation (CBF AR), the body’s physiological mechanism that protects the brain from adverse effects of low brain blood flow (hypoxia/ischemia). In the current descriptive pig study, the primary goal was to compare measurements of CBF AR made with REG to measurements made with other neuromonitoring modalities: laser Doppler flow (LDF); intracranial pressure (ICP); absolute CBF; carotid flow (CF); and systemic arterial pressure (SAP). Challenges administered to anesthetized pigs were severe induced hemorrhage (bleeding) and resuscitation; CO2 inhalation; and positive end expiratory pressure (PEEP). Data were stored on a computer and processed offline. After hemorrhage, the loss of CBF AR was detected by REG, ICP, and CF, all of which passively followed systemic arterial SAP after bleeding. Loss of CBF AR was the earliest indicator of low brain blood flow: loss of CBF AR occurred before a decrease in cardiac output, which is the cardiovascular response to hemorrhage. A secondary goal of this study was to validate the usefulness of new automated data processing software developed to detect the status of CBF AR. Both the new automated software and the traditional (observational) evaluation indicated the status of CBF AR. REG indicates the earliest breakdown of CBF AR; cessation of EEG for 2 seconds and respiration would be used as additional indicators of loss of CBF AR. The clinical significance of this animal study is that REG shows potential for use as a noninvasive, continuous and non-operator dependent neuromonitor of CBF AR in both civilian and military medical settings. Human validation studies of neuromonitoring with REG are currently in progress.
Use of a conical conducting layer with an electrical impedance probe to enhance sensitivity in epithelial tissues
Authors: Kadir Muhammad Abdul , Rabbani K. Siddique-e
Published: January 2019

Tetra-polar electrical impedance measurement (TPIM) with a square geometry of electrodes is useful in the characterization of epithelial tissues, especially in the detection of cervical cancer at precancerous stages. However, in TPIM, the peak planar sensitivity just below the electrode surface is almost zero and increases to a peak value at a depth of about one third to one half of the electrode separation. To get high sensitivity for the epithelial layer, having thicknesses of 200 μm to 300 μm, the electrode separation needed is less than 1 mm, which is difficult to achieve in practical probes. This work proposes a conical conducting layer in front of a pencil like probe with a square geometry of TPIM electrodes to create virtual electrodes with much smaller separation at the body surface, thus increasing the sensitivity of the epithelial tissues. To understand the improvements, if any, 3D sensitivity distribution and transfer impedance were simulated using COMSOL Multiphysics software for a simplified body tissue model containing a 300 μm epithelial layer. It has been shown that fractional contribution of an epithelial layer can be increased several times placing a cylindrical conducting layer in between the tissue surface and the electrodes, which can further be enhanced using a conical conducting layer. The results presented in this paper can be used to choose an appropriate electrode separation, conducting layer height and cone parameters for enhanced sensitivity in the epithelial layer.
Nanostructured device based on coated ZnO layer as a window in solar cell applications
Authors: Mokhtari H. , Benhaliliba M. , Boukhachem A. , Aida M.S. , Ocak Y.S.
Published: January 2019

This work highlights some physical properties related to the influence of aluminum, tin and copper incorporation on nanostructured zinc oxide (ZnO:M; M:Al, Sn and Cu) thin films prepared by ultrasonic spray pyrolysis technique (USP) on glass substrate at 350±5 °C. For the as-grown layers, M- to Zn-ratio was fixed at 1.5 %. The effects of metal doping on structural, morphological, optical and electrical properties were investigated. X-ray diffraction pattern revealed that the as-prepared thin films crystallized in hexagonal structure with (0 0 2) preferred orientation. The surface topography of the films was performed by atomic force microscopy. AFM images revealed inhibition of grain growth due to the doping elements incorporation into ZnO matrix, which induced the formation of ZnO nanoparticles. Optical measurements showed a high transparency around 90 % in visible range. Some optical parameters, such as optical band gap, Urbach energy, refractive index, extinction coeffi-cient and dielectric constant were studied in terms of doping element. Particularly, dispersion of refractive index was discussed in terms of both Cauchy and single oscillator model proposed by Wemple and DiDomenico. Cauchy parameters and single oscillator energy E0 as well as dispersion energy Ed were calculated. Finally, electrical properties were investigated by means of electrical conductivity and Hall effect measurements. The measurements confirmed n type conductivity of the prepared thin films and a good agreement between the resistivity values and the oxidation number of doping element. The main aim of this work was the selection of the best candidate for doping ZnO for optoelectronics applications. The comparative study of M doped ZnO (M:Al, Sn and Cu) was performed. High rectifying efficiency of the Al/n-ZnO/p-Si/Al device was achieved and non-ideal behavior was revealed with n > 4.
The relationship between the TSH values and the Tpeak – Tend interval duration in hypothyroid patients receiving Levothyroxine treatment
Authors: Findikli Hüseyin Avni , Tutak Ayşe Şahin , Aydin Hakan
Published: January 2019

Introduction
. Changes in thyroid hormone level can affect the cardiovascular system. The aim of this study was to show how the Tpeak -Tend (Tpe) interval, which is a new marker of ventricular arrythmia, is affected in patients who have become euthyroid following Levothyroxine treatment for hypothyroidism, as this has not been examined previously in literature.

Materials and Methods
. This, cross-sectional study included a total of 119 females aged 18-45 years, separated into 3 groups as hypothyroid, euthyroid and control groups. For evaluation of the QTc and Tpe intervals, examination on precordial V5 lead was made of all the ECGs taken routinely on presentation of the patients.

Results
. The Tpe and QTc intervals of the hypothyroid group were determined to be significantly prolonged compared to those of the euthyroid and control groups (p < 0.001) and the values of the euthyroid and control groups were similar. A positive correlation was determined between TSH levels and Tpe and QTc intervals. Tpe interval AUC = 0.801 (%95 CI: 0.719 – 0.884) was higher than that of QTc AUC = 0.689 (%95 CI: 0.591 – 0.786).

Conclusions
. The Tpe duration was evaluated in respect of the risk of arrythmia in hypothyroid patients. In patients who had become euthyroid, the Tpe interval was found to be similar to that of healthy individuals and was more predictive than QTc. In the light of these findings it can be recommended that measurement of the Tpe interval should be preferred to QTc as a marker of the arrythmogenic effect in hypothyroid patients.
Myoid Angioendothelioma of the Spleen - Case Report and Literature Review
Authors: Grubor Nikola , Ignjatovic Igor , Tadic Boris , Micev Marjan , Milosavljevic Vladimir , Djordjevic Vladimir , Knezevic Djordje , Matic Slavko
Published: January 2019

Myoid angioendothelioma (MA) represents an extremely rare nonhaematopoietic proliferation of the spleen. MA is a rare, benign, vascular tumour that consists of vascular elements and arranged stromal cells. Due to an absence of specific clinical signs and symptoms, MA is considered challenging to diagnose. Although the radiological presentation can indicate the vascular nature of the tumour, the diagnosis of MA is almost exclusively obtained from the use of histopathology after surgical excision and immunohistochemistry of the tissue. Due to its completely unclear biological behaviour and relationship with other primary and secondary tumours, the only effective therapy for MA is splenectomy and a regular postoperative follow-up. Herein, we report a case of a 26-year-old male patient with nonspecific abdominal pain and a radiologically detected tumour of the spleen who underwent a laparoscopic splenectomy. Histopathologic and immunohistochemical examinations confirmed a myoid angioendothelioma of the spleen.