bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinicopathological spectrum of renal biopsies in children – A single center experience from Eastern India
Authors: S Kanjilal , P Hui , SM Roy , MK Das , S Basu , MK Sinha
Published: October 2023

Background: Renal diseases are common in childhood and they often present with diagnostic challenges. Renal biopsy is of major importance in diagnosing many renal diseases in children. The aim of this study was to evaluate the clinicopathological aspect of renal diseases underwent biopsy in children in a tertiary care teaching institute in Eastern India. Materials and methods: This cross sectional study was conducted on children (≤12 year) admitted with difficult to treat renal disorders in Pediatric ward and thorough evaluations confirmed the requirement of renal biopsy. Sixty one (61) children satisfying the inclusion and exclusion criteria were enrolled in our study. Period of study was from February 2021 to July 2022. Results: In this study, males were 31 and females were 30 in numbers. The mean age was 6.77± 3.42 years. The indications for renal biopsy were steroid resistant nephrotic syndrome (SRNS) (49.18%), systemic lupus erythematosus (SLE) (29.51%), acute glomerulonephritis (AGN) (16.39%), and others. The major bulks of histopathological findings revealed focal segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN) and minimal change disease (MCD) in 45.9%, 32.8% and 13.1% respectively. Hypertension was present in 58.1% and hematuria in 64.5% of cases (p value 0.001). Conclusion: SRNS (49.18%) was the most common indication of renal biopsy and FSGS (45.9%) was the most common histopathological finding in our study. This study provides data on biopsy proven childhood renal disorders from this region.
Impact of promoter region mutations of Pim-1 on c-Myc expression as well as survival in patients with breast cancer
Authors: SS Beevi , K Anbrasu , KK Kannepalli , VK Verma , RR Pillarisetti , S Madigubba , RC Darapuneni , BR Bollineni
Published: October 2023

Purpose: Breast cancer accounts for most cancer-related deaths in women with over 2.3 million new breast cancer cases diagnosed every year worldwide. Pim kinases are oncogenic proteins that play important role in various cancers. Pim-1 contains 1.7 kb promoter region without any transcriptional regulation, which is a characteristic feature of a housekeeping or constitutive promoter. This study was carried out to ascertain potential mutations in the promoter region of Pim-1 in breast cancer and also to comprehend the effect of mutations on c-Myc expression as well as on patients’ survival. Methods: Ninety-six Indian subjects with a first diagnosis of breast cancer who underwent surgery at our hospital were recruited in this study. Genomic DNA was isolated from whole blood, amplified and sequenced to identify potential mutations at the promoter region of Pim-1. FFPE sections were used to determine the c-Mycexpression in all the studied groups. Results: We observed a transversion (C>A at –502) and a deletion (–754Cdel) mutation in the promoter region with negligible association with tumor biology and c-Myc expression. Positive c-Myc expression was noted in almost 50% of the studied population with absolute nuclear staining or both cytoplasmic/nuclear staining. As per survival analysis, promoter region mutations did not modulate the patients’ survival, but patients with negative c-Myc expression had better disease-free survival compared with positive c-Myc expression. Conclusion: Our findings identified the presence of mutation in the promoter region of Pim-1 with negligible impact on c-Myc expression in patients with breast cancer.
Standardized cytopathology reporting of fluids using newly proposed international system for reporting serous fluid cytology - A single institutional experience
Authors: R Murugan , S Kandasamy , KP Gunasekaran , GS Ramalingam , AL Kulandaivel
Published: October 2023

Background: Serous fluids are commonly produced in many disease conditions and it is relatively easy to collect it. Subjecting it to analysis will help identify the etiology of the disease process and thereby help the clinicians to plan the treatment strategy appropriately. The application of the international system for reporting serous fluid cytology will further make it easy for the clinicians with its simpler terminologies and clear categorization of entities. Materials and method: All effusion samples that were received from 2020 to 2022 were examined and categorized according to international system for reporting serous fluid cytology. Risk of malignancy (ROM) was also calculated. Results: Among 400 cases, 140 (35%) were pleural fluid, 260 (65%) were ascitic fluid. Among 140 pleural fluid, 8 (5.7%) were ND, 121 (86.4%) were NFM, 2 (1.4%) were AUS, 5(3.6%) were SFM and 4 (2.9%) were MAL. Among the 260 peritoneal fluid, 13 (5%), 226 (86.9%), 9 (3.5%), 9 (3.5%), and 3 (1.1%) were reported as ND, NFM, AUS, SFM and MAL respectively. Risk of Malignancy (ROM) calculated for the cases collected in this study were 0% for ND, 0.9% for NFM, 45.5% for AUS, 71.4% for SFM and 100% for MAL. Conclusion: The international system (TIS) for reporting serous fluid cytopathology is very easy to employ and gives high accuracy with clear diagnostic criteria for each category, hence makes it easy to communicate with the clinicians by employing simple terminologies.
Mallipudi hernioplasty: A novel tension free open incisional hernia repair
Authors: BVP Mallipudi
Published: October 2023

Surgical management of incisional hernia remains a challenge to surgeons practicing the art of hernia repair. A novel tension free open incisional hernia repair combined with abdominal panniculectomy is described in detail. Our unpublished data of over 200 patients shows a recurrence rate of 2% over a ten-year period with follow up ranging between 2 to 15 years. This is an excellent technique for open incisional hernia repair.
Demographic and histopathologic study of soft tissue lesions in a tertiary care hospital in South India
Authors: R Priavadhana , K Meenakshisundaram , T Rajeswari , A Kunnumbrath
Published: October 2023

The term soft tissue tumors (STT) encompass a wide range of tumors arising from the mesenchymal tissues. In this study, we have retrospectively analysed the various STTs occurring in the Department of Pathology and included all cases with a confirmed histopathological diagnosis of soft tissue lesions received during the study period of January 2018 – December 2019. These cases were further analysed for the site of the lesion, number of lesions, age and gender of the patients and the results tabulated. A total of 207 cases of soft tissue tumors with confirmed histopathological diagnosis were included in this study. The male: female ratio was 1.1:1. It was observed that most of the soft tissue tumors were seen in the 31-40 years age group (33%) followed by the 41-50 years age group (21%). The most common histopathologic subtype of tumors were of adipocytic origin (61%). Malignant morphology was observed in 2.4% of the cases. Soft tissue tumors are not uncommon tumors and account for 5.2% of cases among the routine histopathological specimens. This study is presented here to understand the demography and the spectrum of soft tissue tumors observed in a tertiary care centre.
Assessment of cockpit information and control field using neural networks and methods
Authors: Makhortov I.A. , Greshnikov I.I.
Published: October 2023

The paper deals with the methodology of estimating the cockpit information and control field using indicators of oculomotor activity and a probabilistic neural network, which is used to calculate the final estimate of the considered display version. This methodology was tested on the universal prototyping bench basis with the participation of pilots. The using of this methodology contributes to the rapid and qualitative ergonomic assessment of the cockpit information and control field, which in turn increases the efficiency of human-machine interaction and, as a consequence, the safety of air transportation.
Probabilistic Neural Network Application to Speech Recognition Problem
Authors: Levonovich N.I. , Kozyrev A.D.
Published: October 2023

This article discusses an approach to solving the problem of speech recognition based on probabilistic neural networks. The problem is formulated as a problem of command recognition. Commands have equal lengths (in words). Each word position has its own set of candidates. The recognition algorithm for solving this problem was developed. The core of the algorithm is a probabilistic network that recognizes modified estimates of spectral densities. The algorithm allows for high precision of recognition, which is sufficient for the creation of a voice user interface.
Identification of the Interval Constants of the Rates of the Chemical Reaction of Naphthalene Oxidation
Authors: Morozov A.Y.
Published: October 2023

In this work, the previously developed approach of parametric identification of dynamic systems with interval parameters is applied to the problem of finding the rate constants of the chemical reaction of naphthalene oxidation. This reaction is of practical importance in the production of plastics and paints and varnishes. The essence of the considered approach lies in the compilation of the objective function in the space of the boundaries of the interval parameters and characterizing the deviation of the model solution from the experimental data. For the objective function, it is possible to construct a gradient and use first-order methods to optimize it. The approach is based on the adaptive interpolation algorithm, which makes it possible to obtain solutions for direct interval problems in the form of explicit parametric sets. The found interval estimates of the rate constants are consistent with the known ones, but at the same time they have a smaller width, which demonstrates the advantage of the approach used.
Using Heat Maps to Optimize Educational Business Processes in The Skill Box Company
Authors: Dolgikh A.D.
Published: October 2023

The article addresses data analysis methods for solving the problem of choosing the best solution in order to optimize resources using the example of Skillbox company. The problems of choosing information resources are considered and solved, taking into account market offers. The author considers various methods of data analysis with an emphasis on minimizing the resources required for their processing. In the article, the author describes the practical application of the "Digital Assistant" program, which was developed by the Skillbox company to measure product metrics and analyze the behavior of students. Using the big data analysis methods described by the author, ways to optimize educational business processes that lead to an increase in the profitability of educational courses are considered. Heat maps are considered as one of the main ways to analyze big data, and their practical application is described. The author describes the relationship between business metrics and changes occurring with the educational product and suggests methods and frequency of surveys and feedback processing about the educational path of students.
Acoustic Signal Classification in Underwater and Air Environments
Authors:   , Vo Quoc Thinh , Han David
Published: October 2023

Identifying various acoustic sources can be challenging in both air and underwater settings. This is largely due to the difficulties in data collection, especially in ocean environments, and the variety of background noise they pose. Transformer architecture with self-attention mechanism has proven effective across various machine learning tasks, such as Natural Language Processing (NLP) and image recognition, even in challenging environments. This thesis presents the applications of Transformer in both air and underwater domains. In the air, we developed a Hierarchical Knowledge Distillation (H-KD) framework that utilized the Audio Spectrogram Transformer (AST) [1] architecture as a teacher model. The framework was designed using a multi-stage learning approach and cross-model integration to enhance performance of a low complexity Convolutional Neural Networks (CNN) student model. We applied it to an air acoustic dataset - TAU Urban Acoustic Scenes 2023 Mobile development [2] and demonstrated that it achieved a significantly improved performance compared to the Baseline system [3]. After verifying the model on publicly available datasets, our proposed model was submitted to the 2023 IEEE AASP Challenge on Detection and Classification of Acoustic Scenes and Events (DCASE2023) [3]. In the underwater acoustic signals experiment, we modified and adapted the Hierarchical Token Semantic - Audio Transformer (HTS-AT) [4] architecture to make it better suited underwater environments. We applied it to an underwater acoustic dataset - shipsEar [5] and demonstrated that our proposed method outperformed some of the latest classification methods. The promising results obtained motivate further exploration of Transformer-based approaches in future research to advance the state-of-the-art (SOTA) in Acoustic Signal Classifications (ASC).
Staging I in a Gastric Adenocarcinoma Cohort Description of Clinical, Imaging and Pathological Findings
Authors: Arantes Paola , Fernandes Gisele , Silva Diego , Coimbra Felipe , Calsavara Vinícius , Tiengo Tatiane , Curado Maria
Published: October 2023

Background: Gastric cancer was the fourth cause of cancer-related deaths in 2020 in the world. The aim of this study was to describe the characteristics of patients with gastric adenocarcinoma Stage I describing clinical, pathological, and neoadjuvant staging in a prospective cohort at A.C. Camargo Cancer Center (ACCCC). Methods: Sixty-three patients with Stage I gastric adenocarcinoma treated at ACCCC were evaluated for clinical, pathological, and clinical Stages. For the comparison between the clinical staging and the post-treatment one (surgical and neoadjuvant): tumor (T) and lymph nodes (N) were evaluated. Results: Of the 63 patients, 29/63 (46%) were clinical Stage I, and 34/63 (54%) were initially staged as clinical Stage II and III that migrated to Stage I after surgical and neoadjuvant treatment. As for the clinical aspects, 36/63 patients (57%) were men with an average age of 58.7 years, 63% patients were Caucasian and 83% (52) had private medical insurance. In the endoscopic reports, 68.3% (n=43) of the lesions were ulcerated and the histological type, 55.6% (n=35) were diffuse. Patients treated with neoadjuvant therapy had a 100% reduction of tumors T3/T4 to T1/T2 (p<0.001) and 78.5% of the regional lymph nodes, N+ to N0. (p=0.001). Conclusion: The neoadjuvant therapy on patients with gastric adenocarcinoma led to significant tumor (T) and regional lymph nodes (N) regressions, thus, increasing the migration of cases from T3/T4 to T1 /T2 and N+ to N0 in this cohort.
Dutch Settlers at Voorzorg in Suriname Decimated by 1845 Epidemic: A Multifaceted Approach to Unravel Mystery about Etiologic Microbial Agent
Authors: Dissel Jaap , Altena Eveline , Gaalen Rolina , Laros Jeroen , Pieterse Philip , Muller Axel , Gaag Kristiaan , Leeuw Rick , Vries René , Adhin Malti
Published: October 2023

Background. In 1845, an attempt at Dutch farmer colonization of the overseas colony of Suriname failed because within weeks of the arrival of 384 colonists, an outbreak occurred that killed half of them. The outbreak at plantation Voorzorg was identified as ‘gastric biliary fever’, which was later interpreted as typhoid fever. However, sparse data support this diagnosis. Herein, we took a multifaceted approach to characterize the outbreak and establish the likely microbiological cause. Methods. Archival research was combined with identification and excavation of a burial site, analysis of aDNA of skeletal remains as well as modelling of the outbreak on epidemiological findings. Results. A timeline of events constructed from archival records revealed that the 1845 febrile illness affected >95% of the 384 colonists, likely transmitted human-to-human and was characterized by fever, nausea, vomiting, in cases abundant often bloody diarrhea, and progressed into delirium and stupor (‘Typhus’). Within 1-2 weeks of symptom onset, half of the affected persons died (189 of 384) with overrepresentation from the young and elderly. A few postmortems had revealed multiple small, purulent colonic ulcerations. We discovered a burial ground and uncovered 17 skeletal remains presumed to be colonists. Subsequently, metagenomic testing did not reveal a pathogenic microorganism fitting the disease description, but typing mitochondrial DNA (possible in 15 of 17) showed that the skeletal remains sampled likely did not originate from Europe. Mathematical modelling of epidemic curves depicting cumulative mortality of those arriving by subsequent ships revealed that transmission characteristics of bacillary dysentery rather than typhoid fever fitted the epidemiological findings the best. Conclusion. A multifaceted approach revealed that the 1845 outbreak at Voorzorg among Dutch colonists was probably caused by bacillary dysentery and not typhoid fever. Likely, the high mortality was a consequence of dehydration that in tropical conditions particularly affected the young and elderly. This outbreak contributed to the failed colonization attempt.
Nutritional value of cane broth and nutraceutical potential of Caná – cane broth´s fermented drink
Authors: Maia Amazile
Published: October 2023

Brazil is the world's largest producer of sugarcane and its juice is used mainly for the production of sugar, fuel alcohol and industrial cachaça. To a lesser extent, thousands of producers cultivate sugarcane on a rural scale, for the production of alembic cachaça, brown sugar, rapadura and molasses. In recent years, however, these producers have been looking for options that, in addition to expanding the range of products, allow them to add more value to their properties and sugarcane fields. In this context, the feasibility of producing fermented sugarcane juice as a final drink, similar to grape wine, has been considered. The market potential of this beverage has been markedly expanded as a result of recent research, which proved the presence of phytoactive substances in sugarcane juice, such as apigenin, luteolin and asterin, among others. Continuing these works - which have already made it possible to scientifically support millenary practices related to the use of sugarcane juice in Ayuvedic medicine - is very important, both to reinforce the appreciation of sugarcane juice in the human diet and to enable the classification of the fermented sugarcane juice as a beverage with functional activity, following the example of the recognition already won by wines that come from the fermentation of grape juice. To contribute in this direction, an update is presented in the scope of the chemical composition of the sugarcane juice, highlighting the main phytoactives already characterized.
Endoscopic-Assisted Electrochemotherapy Versus Argon Plasma Coagulation in Non-Curable Esophageal Cancer – A Randomized Clinical Trial
Authors: Egeland Charlotte , Baeksgaard Lene , Gehl Julie , Gögenur Ismail , Achiam Michael
Published: October 2023

Background: In this randomized clinical trial, we compared endoscopic-assisted electrochemotherapy (ECT) with argon plasma coagulation (APC) in patients suffering from esophageal cancer. We hypothesized that an initial, local tumor treatment could prevent or prolong the time to severe, obstructive dysphagia. Previous studies suggest that ablative therapies might have survival advantages compared with placing an esophageal stent. Methods: We aimed to include 50 patients with non-curable esophageal cancer. Patients were randomized to ECT or APC (1:1) as an upfront treatment and hereafter referred for standard treatment. The primary endpoint was the difference in time to interventional treatment demanding dysphagia. Secondary endpoints included side effects, symptom palliation, tumor response, and survival. Results: Ten patients were included (the study was prematurely terminated due to recruitment challenges), and the results are, therefore, mainly exploratory. Five patients received ECT, and four patients received APC. The median survival time among all patients was ten months. Two patients in the APC group and no patients in the ECT group had an esophageal stent placed during the follow-up period. One month after treatment, dysphagia relief was observed in five patients (two patients in the ECT group), and four patients had a partial response evaluated from CT imaging (three patients from the ECT group). No severe adverse events were registered in either group. Conclusion: ECT and ACP were administrated as initial therapy with few side effects, and none of the patients in the ECT group developed interventional treatment demanding dysphagia during their remaining lifetime. Future studies with ECT should focus on both symptom palliation, the need for re-intervention, and survival.
Glucose Transporter-1 and Tumor Size Affect Assessment in Gastric Cancer on SPECT
Authors: Yin Chenqing , Nan Yule , Yang Ju
Published: October 2023

Background: GLUT-1 expression is the crucial parameter affecting gastric cancer 18-FDG absorption is still controversial. This study is to explore the significance of GLUT-1 in gastric cancer 18-FDG SPECT. Material/Methods: The gastric cancer samples of 134 patients with preoperative 18-FDG SPECT were assessed by GLUT-1 immunohistochemi­cal staining. The clinicopathological information of enrolled patients were analyzed with univariate and regression analyses. Results: The SUVmax in positive GLUT-1 expression was significantly higher than that in negative expression (5.136±3.088 vs 4.003±3.604, p=0.004). Tumor diameter (OR 1.415, p=0.005) and GLUT-1 expression level(OR 1.683, p=0.041) were the factors associated with imaging results by visual assessment, independently. Tumor diameter was independent factor associated with SUVmax in positive imaging cases (p=0.029). Tumor diameter(p=0.003) and tumor differentiation(p=0.026) were independent factors related to SUVmax in differentiated carcinoma cases. Conclusions: GLUT-1 expression level is major factor determining 18-FDG uptake of gastric cancer on SPECT. It is necessary to verify the result with PET/CT. Further investigation on analysis GLUT-1 expression in lesions of gastric cancer metastases and recurrences is required.
An innovative approach for treatment of anterior open bite in Class II Division 1 patient with VF appliance (Zygomatic Implant and Spur Assisted) - A case report
Authors: Faseehuddin Muhammed , Fazal-ur-Raheman Chowdary  , Patil Vishwanath S , Patil Basangouda C , Kencha Akash , Abrar Younus A
Published: October 2023

Controlling anchorage is one of the foremost necessary aspects of treatment. Moderate anchorage is comparatively simple to manage with the use of some intraoral appliances and biomechanical procedures. On the opposite hand, cases that need the most anchorage need extraoral support to strengthen the anchorage. In some instances, 100 percent anchorage has got to be maintained, such an anchorage may be termed as absolute anchorage. It's tough and not possible to get absolute anchorage by using typical ways like extraoral force application. In this case report, we describe the treatment of Open bite by using the support of Zygomatic plates and Spurs anteriorly placed with the combination of posterior bite blocks. A 20-year-old female reported to our department of orthodontics with the chief complaint of anteriorly placed upper front teeth. There was no relevant medical history; she was having tongue thrusting habit, acute nasolabial angle and incompetent lips. Overjet of 12mm and anterior skeletal open bite from canine to canine of 5mm was present associated with anterior tongue thrusting habit, and constricted upper arch. The molar relation was end-on on the right side and class II on left side. Canine relation is end-on, on both the side. Growth pattern is vertical. Upper arch is well aligned with constriction in premolar region; lower arch has crowding of 6 mm. The treatment plan was selected as alignment of the teeth with fixed mechanotherapy and impaction of the maxillary posteriors using zygomatic anchorage with posterior bite block and spurs soldered to the anterior part of the appliance. The sutures were removed after 7 days, the appliance was inserted into the patient’s mouth and secured with a power chain to the hooks of the appliance and the hook of zygomatic implant, 400gms of force was applied on both the sides.
La temprana recepción de Max Weber en la sociología argentina (1930–1950)
Authors: Blanco Alejandro
Published: October 2023

Antes de las primeras traducciones de Max Weber al español, Historia económica general y Economía y sociedad, ambas editadas por el Fondo de Cultura Económica en 1942 y 1944 respectivamente, su pensamiento ya era conocido en Argentina por aquellos que tenían a su cargo la enseñanza de la sociología en las universidades. Las primeras referencias a sus trabajos aparecieron a comienzos de la década de 1930 en un contexto intelectual caracterizado, en términos generales, por una revuelta contra el positivismo y la difusión del pensamiento alemán en general y del pensamiento sociológico en particular. Durante aquel período la sociología era un campo emergente y los sociólogos enfrentaban la tarea de justificar su dominio de conocimiento y sus respectivas perspectivas analíticas. En este contexto, se podría preguntar, ¿quién fue Weber para loslectores argentinos? ¿Qué temas de su vasta obra fueron seleccionados en el contexto de las preocupaciones locales? Este ensayo explora, entonces, las diferentes interpretaciones de las ideas de Max Weber e intenta mostrar cómo estas últimas se articularon con diferentes concepciones de la disciplina.
Chávez. El mito de la comunidad total
Authors: Arenas Nelly
Published: October 2023

Este artículo expone la idea de comunidad total presente en el proyecto chavista mediante el análisis del discurso y la acción del régimen. Se trata de un estudio que parte de determinadas nociones conceptuales sobre las mitologías políticas y el papel que el deseo de unicidad social juega en ellas.
Castidad y honestidad sexual de la mujer joven en la justicia
Authors: Fondevila Gustavo
Published: October 2023

Este artículo analiza el modo en que el ámbito judicial ha perfilado la conducta sexual aceptable de la mujer joven en la sociedad mexicana. Desde que inicia el siglo XX hasta fechas recientes, los elementos de los tipos penales relativos a delitos sexuales han servido para construir un ideal (moral) socialmente aceptable de sexualidad juvenil. En este sentido, tanto el juicio social como el resultado del proceso judicial coinciden en definir dicho ideal bajo la forma de la castidad, la honestidad sexual y la pureza sexual.
Reformas comerciales y cambios en el precio al productor de maíz en México
Authors: Contreras Castillo José María
Published: October 2023

En este artículo se aplica un método para descomponer el cambio en el precio interno al productor de maíz en México durante el período 1994–2005 y medir la contribución relativa de las variaciones en el precio internacional, los movimientos de la tasa de cambio y la modificación en la política comercial. Se concluye que la eliminación del permiso de importación, combinada con la decisión del gobierno mexicano de aplicar arancel cero a las importaciones y de no instrumentar el calendario de desgravación arancelaria acordado, es el factor principal que explica la reducción en el precio interno al productor de maíz. Sin embargo, en el contexto de una mayor transmisión de precios, el descenso en el precio internacional del maíz y la apreciación de la tasa de cambio real también contribuyen a dicha caída.
Calculation of the Passenger Aircraft Landing Gear Shock Absorption System Exposed to Impact Loading
Authors: Belkin A.E. , Nikitin E.A.
Published: October 2023

The paper considers the shock absorption system of an advanced domestic mainline passenger aircraft, which includes oleo-pneumatic shock absorbers and wheels equipped with the pneumatic tires. Nonlinear mathematical models of single-active and two-active oleo-pneumatic shock absorbers of telescopic landing gear supports are proposed. The models take into account the process of polytropic gas compression, the forces of hydraulic resistance to the working fluid flow and the forces of dry friction arising in the system moving parts. To describe the vertical compression reaction of the pneumatic tires, the V.L. Biderman structural model was introduced, which parameters were determined by test results using the least squares method. Motion equations of the landing gear elements were obtained by the analytical mechanics methods involving the Ostrogradsky --- Hamilton variational principle of least action. Constraints imposed on the system were introduced using the penalty functions method. The problem statement of carrying out virtual computational experiments on the landing gear dvops was considered. In a wide range of the impact energies, models of shock absorbers of a passenger aircraft landing gear were validated, for which time realizations of the system state vector were determined, and areas of hysteresis loops of the shock absorber load characteristics were evaluated by the numerical integration. Satisfactory compliance of the results of simulated characteristics of the natural objects was shown. The obtained results could be used to improve the absorption quality criteria by numerical optimization methods, calculate the landing impacts and analyze the aircraft oscillations when moving on the runway
Analysis of Codon Usage Bias of Six Genes of Replicase/Coat Protein of Tobacco Mosaic Virus
Authors: Cheeran Kevin , Suresh Kuralayanapalya Puttahonnappa , Jacob Siju Susan , Gowda Chirathahalli Shivamurthy Sathish , Gejendiran Narayanan , Sridevi Rajangam , Patil Sharanagouda S.
Published: October 2023

Background: Tobacco mosaic virus (TMV) stands as a highly studied virus and consequently, its features and composition are extensively understood. It has been found to induce diverse infections in numerous plant species, with tobacco leaves being notably affected, showing mottled browning. Presently, the sole available method to control its spread is by removing infected plants. Understanding codon use bias is crucial as it could play a pivotal role in molecular interventions aimed at halting the virus’s replication and multiplication, thereby helping to contain its propagation. Methods: Currently, the research focuses on assessing codon bias within six genes related to the replicase/coat protein of TMV, namely TMVgp1, TMVgp2, TMVgp3, TMVgp4, TMVgp5 and TMVgp6. To conduct this analysis, various methods such as relative dinucleotide abundance, relative synonymous codon usage (RSCU), neutrality plot and parity rule 2 (PR2) plot were employed. Result: All of the identified genes had a modest codon bias, according to the study on codon usage, as well as the function of mutation pressure in gene TMVgp3 and natural selection in genes TMVgp1, TMVgp2, TMVgp4, TMVgp5 and TMVgp6. The Research into codon use bias showed that the TMV virus’s chosen genes are subjected to naturally occurring selection as well as mutational pressure.
The use of digital tools in French as a Second Language teacher education in Ontario
Authors: Boreland Taylor , Lotherington Heather , Tomin Brittany , Thumlert Kurt
Published: October 2023

This article discusses a 2021 survey of French as a second language (FSL) teacher candidates (TCs) in Faculties of Education in Ontario whose practice teaching experiences were affected by the COVID-19 pandemic, pivoting them into remote FSL teaching and learning. The survey, which formed a component of a larger mixed method SSHRC-funded research project1, was designed to capture the varied practice teaching experiences of FSL teacher candidates in order to ascertain symmetries and asymmetries in their preferred digital practices, devices and tools for social communication, and for French language teaching and learning. Survey respondents (N=17) from different teacher education programs in universities across Ontario provided a picture of scattered and fragmented approaches to FSL digital pedagogies and hinted at a persistent reliance on traditional FSL pedagogies in the classroom. Digital preferences for teaching and learning were, interestingly, not parallel, and were anchored in common educational tools and platforms that reaffirmed teacher-centred approaches to FSL rather than more innovative, learner-centred, and agentive language teaching and learning. The survey results raise an important question: Has FSL teacher education adequately moved with the communicative changes wrought by socio-technical change and related pedagogical innovations?
Conduct Disorder: An Update
Authors: ÖZBAY Ahmet , ÖZÇELİK Osman , KAHRAMAN Süleyman
Published: October 2023

Conduct disorder is a serious mental disorder with a heterogeneous etiology that is frequently encountered in child and adolescent psychiatric clinics, although there are social and international differences. Conduct disorder can be defined as violating the basic rights of others, age-appropriate social norms and values, or existing rules with consistently aggressive behavioral patterns. It has been defined under various headings since DSM-II and most recently in DSM-5 under the heading "Disruptive Disorders, Impulse Control and Conduct Disorders". Genetic, individual, and psychosocial factors play a role in the etiology and constitute a broad etiology. Although its onset dates to childhood, if assistance is not sought, it can lead to more serious mental disorders. Conduct disorders are associated with several mental disorders. Therefore, a differential diagnosis should be made and an effective treatment option should be established. No specific medications were available for treatment. Different disciplines can collaborate for a long time to achieve successful results. In this article, the definition of conduct disorder, DSM-5 diagnostic criteria, epidemiology, etiology, comorbidity, differential diagnosis, prognosis, and treatment approaches are reviewed.
Psychometric Validation of the Korean Version of the Family-Centered Care Questionnaire—Revised
Authors: Han Jihee , Oh Won-Oak , Heo YooJin , Kim Sunho
Published: October 2023

Background and Purpose:Family-centered care (FCC) is a philosophy of care that applies to all areas of pediatric nursing and is a key component of the care model for patient safety and management activities in the medical environment of hospitalized children. The aim of this study was to translate and evaluate the psychometric properties of the Korean version of the Family-Centered Care Questionnaire—Revised (FCCQ-R).Methods:A total of 239 questionnaires were completed by pediatric nurses at four consenting general hospitals.Results:Fourteen items were removed from the original questionnaire through exploratory factor analysis and nine subscales were reduced to five. The factor loadings of the 30 items on the five subscales ranged from 0.50–0.80. The model of the Korean version of the questionnaire was validated by an exploratory and confirmatory factor analysis. Reliability analysis for internal consistency showed an acceptable to high Cronbach’s α of 0.96 in total and the subscales ranged from 0.59–0.92.Conclusions:This study verified the validity and reliability of the tool to measure the perception of FCC. Future research will need to correlate FCC with more relevant measures, such as the nurse–parent partnership measure tool, to confirm predictive and concurrent validity. The Korean version of the FCCQ-R of 30 questions on five subscales is a valid and reliable measurement of Korean nurses’ perceptions of FCC.
Development of a Pediatric Behavioral Early Warning Scale (Pedi-BEWS) for Children
Authors: Eisenstein Maureen , Chung Joohyun , Domaleski Vareen , Lantz Susan
Published: October 2023

Background and Purpose:The prevention of aggressive behavior in child and adolescent inpatient settings is essential. However, it can be difficult to prompt a quick appropriate intervention without an early warning scale for the prevention and management of behavioral emergencies in a psychiatric inpatient adolescent unit. Behavioral emergencies often result in restraint/seclusion and/or administration of psychotropic medications. The objectives are to develop and evaluate the Pediatric Behavioral Early Warning Scale (Pedi-BEWS) as a screening tool to prompt quick appropriate interventions and to decrease incidents of restraint/seclusion and/or administration of psychotropic medications.Methods: A two-phase methodological design was applied. A total of 447 inpatients and 21 nurses were used to test internal consistency reliability and validity.Results: Receiver operating characteristic curve areas for the developed instrument were calculated to be 0.890 (cognition), 0.959 (affect), and 0.951 (behavior). The overall Pedi-BEWS indicated high reliability (Cronbach’s alpha = .98).Conclusions: The Pedi-BEWS shows high internal consistency and validity. The use of the newly developed tool may reduce or eliminate episodes of seclusion and restraint for pediatric patients with a behavioral problem. In addition, the tool has the potential to enhance psychiatric nurses’ assessment skills and competencies. The use of the newly developed Pedi-BEWS can promote an appropriate and timely nursing assessment and intervention before the deterioration in psychiatric nursing practice.
Propuesta de bloque no portante a base de concreto, escoria de acero y PET para mitigar el impacto ambiental ocasionado por los bloques tradicionales en nuevas construcciones en la provincia de Ica-Perú
Authors:   , Díaz Núñez Antonio Fernando , Pacheco Garriazo Mariajulia Fernanda
Published: October 2023

En esta tesis se investigo acerca de la escoria de acero y el tereftalato de polietileno (PET) como posibles reemplazos del agregado fino en diferentes porcentajes para la elaboración de bloques de concreto no portante; Dando así una alternativa para mejorar la gestión de residuos en la región de Ica-Perú. Para esta investigación se realizó el análisis de las propiedades físicas, químicas y posibles usos de la escoria de acería y el PET, tomando como referencia también investigaciones previas, nacionales e internacionales. Además, se propusieron 4 dosificaciones; Una dosificación patrón y tres dosificaciones con escoria de acero y PET. Mediante ensayos realizados a 48 bloques no portantes, se busca obtener resultados que permitan identificar la evolución en el comportamiento de los bloques al incorporar materiales reciclado en las mezclas de concreto. Finalmente, se realizó un análisis económico y ambiental para comprobar la factibilidad del uso de estos materiales como posibles reemplazos del agregado fino en la elaboración de bloques no portantes, tomando en consideración además las ventajas que ofrecen al ser incluidos en estos.
Las barreras funcionales y su relación con la oferta exportable de las empresas exportadoras de peces ornamentales entre los años 2009 - 2021 en la región Loreto
Authors:   , Borboy Vera Yefry Guissephe , Celis Soria Diego Luis
Published: October 2023

Durante los últimos 15 años, el rubro de las exportaciones no tradicionales de la región Loreto ha tenido un comportamiento interesante, especialmente las exportaciones de peces ornamentales a distintos mercados, específicamente al continente asiático. Esto venía generando grandes utilidades a los empresarios exportadores al igual que varios puestos de trabajo. Según TradeMap, el Perú se encuentra dentro de los primeros 20 países a nivel mundial que exportan peces ornamentales, es de la región Loreto donde se crían y capturan estas especies tan solicitadas por países asiáticos, europeos y del norte de América. Sin embargo, en los últimos años a raíz de la pandemia y otros factores externos como lo son la informalidad y crisis mundial, este sector se ha visto afectado haciendo que muchas empresas cierren sus operaciones. La finalidad de la presente tesis es estudiar y observar cómo las barreras funcionales que enfrentan las empresas exportadoras de peces ornamentales guardan relación con la oferta exportable de las mismas compañías dedicadas a este negocio entre los años 2009 - 2021. Teniendo como variables a las “barreras funcionales” que abarcan las áreas de RRHH, producción y finanzas y por otro lado la “oferta exportable” que comprende la capacidad de gestión, capacidad económico-financiera y capacidad física. Se realizaron entrevistas a expertos del rubro para conocer el diagnostico actual del rubro y de las organizaciones involucradas. Para el desarrollo del trabajo, se utilizó una técnica de estudio cuantitativo con diseño descriptivo correlacional. Asimismo, para recoger la información cuantitativa, se elaboró una encuesta tipo cerrada en escala de Likert, la cual fue aplicada a 15 empresas vigentes que exportan constantemente peces ornamentales, estas fueron desarrolladas por los dueños o administradores de estas Luego se llevaron los datos en el SPSS y se concluye que si existe una relación entre estas dos variables. Las empresas del sector deben contar con las áreas de recursos humanos, finanzas y producción correctamente establecidas para poder seguir vendiendo en los mercados internacionales.
Factores que se relacionan con la intención de compra de smartphones en jóvenes de 20 a 39 años de los distritos de San Borja, San Isidro y Miraflores
Authors:   , Ubierna Barandiarán Mariel , Salas Chacón Guillermo Humberto
Published: October 2023

Hablar de smartphone o teléfono inteligente ya es parte de la vida cotidiana desde hace varios años y es un elemento que será de un importante uso a mediano y largo plazo. En la presente investigación, se han revisado los factores que se relacionan con la intención de compra de dicho equipo por jóvenes de 20 a 39 años de los distritos de San Borja, San Isidro y Miraflores. A partir de la lectura de literatura académica se han establecido 4 factores que se han considerado importantes: Características técnicas del producto, precio, marca e influencia del grupo social de referencia. Al final del estudio, se han determinado los dos factores más relevantes para el segmento etario seleccionado, los cuales fueron: características técnicas del producto del producto y precio; y los dos menos relevantes: marca e influencia social. Con la presente investigación, se brinda información para que compañías manufactureras y operadoras puedan, a partir de datos recientes, conocer de qué es lo más apreciado, en la actualidad, por el segmento estudiado y poder introducir al mercado los productos que satisfagan esa necesidad.
Determinantes de satisfacción y lealtad en la calidad del servicio logístico del recojo en tienda
Authors:   , Avila Quilcat Maria Elizabeth , Quispe Mendez Karla Yessenia
Published: October 2023

El presente trabajo de investigación busca analizar el canal de distribución identificado como recojo en tienda para conocer cómo las dimensiones de la variable calidad del servicio logístico (LSQ, logistic service quality) como la puntualidad, la disponibilidad, la conveniencia y la condición, juntamente con la variable precio -que midió la ventaja o utilidad económica del canal- influyen en la satisfacción y la lealtad con el canal después de su uso. El estudio transversal, con un enfoque cuantitativo de alcance explicativo, aplicó una encuesta online autoadministrada a 400 compradores de tiendas por departamento que en los últimos 6 meses habían adquirido algún producto de la categoría ropa, calzado o accesorios utilizando la opción de Recojo en Tienda como canal de distribución. Para estudiar la relación de las variables se utilizó la técnica de ecuaciones estructurales basada en la varianza (PLS-SEM) a través del programa Smart PLS. La variable LSQ se dividió en dos: conveniencia, que por su relevancia se consideró una variable independiente separada y servicio total, la segunda variable así nombrada porque agrupó al resto de dimensiones de LSQ. Los resultados de este modelo comprobaron que la conveniencia tiene una influencia en la satisfacción y la lealtad, mientras que el servicio total solo tendría influencia en la satisfacción, mas no en la lealtad con el canal recojo en tienda. El resultado de la influencia positiva de la satisfacción en la lealtad se mantuvo.
Modelo lean startup de gestión comercial basado en marketing digital para el incremento de ventas en empresas del sector alimentos saludables
Authors:   , Lazo Durand Rafaela Andreina
Published: October 2023

En el año 2018, el ministerio de salud informó que más del 50% de la población peruana sufre de obesidad. Lima metropolitana cuenta con el 40% de personas afectadas con esta enfermedad. Además, un informe del diario gestión que dice que, en promedio, cada ciudadano peruano consume 52 kg de alimentos ultra procesados al año. Estas alarmantes cifras demuestran que es necesario un cambio en el estilo de vida de los ciudadanos limeños. Es necesario concientizar a las personas sobre la importancia de llevar un estilo de vida saludable, esto implica mejorar sus hábitos alimenticios y realizar deporte. Dado el aumento de personas con problemas de salud ocasionados por la mala alimentación, la fabricación de productos saludables, como es el caso de las mantequillas de frutos secos, deben ser naturales, sin azúcar añadida, aceites hidrogenados, añadidos químicos ni conservantes. Los frutos secos pertenecen al grupo de alimentos energéticos, su consumo aporta grandes beneficios a la salud y ayuda a combatir la obesidad. Es una fuente rica en proteínas y grasa saludable, aportan energía, contienen vitaminas y antioxidantes, entre otros beneficios. Además, es apto para vegetarianos, veganos, celiacos y diabéticos. Es por ello que la fabricación y venta de mantequillas de frutos secos artesanales es una oportunidad de negocio en Lima. Para demostrarlo, se utilizó la metodología Lean Start-up, en la cual, mediante el desarrollo de productos minímos viables demostró la viabilidad del proyecto. Se utilizaron las bases de gestion de proyectos según el Project Management Institute (PMI) para guiar el desarrollo del mismo, además de herramientas de marketing digital para dar a conocer los productos al mercado objetivo.
La influencia de los programas estatales en el proceso de internacionalización de las empresas peruanas en la región de Lima que comercializan la tara en polvo (14.04.90.20.00) a Brasil en los años 2017 al 2021
Authors:   , Calderon Jara Nikoll Braian , Martel Vera Brandon Alonso
Published: October 2023

En la actualidad, el mercado de los productos agrícolas ha tenido un gran crecimiento tanto a nivel local como internacional, según ComexPerú en el año 2022 las exportaciones de productos agrícolas crecieron en 22.1% en el primer semestre con respecto al año anterior, esto se debe a que muchos de los productos tienen muchos beneficios nutricionales y algunos pueden ser utilizados en múltiples industrias, lo cual hace que el producto suba su valor. Es por ello que las empresas productoras de estos insumos buscan abrir sus fronteras con mayor rapidez para generar ingresos mayores. En el caso del mercado de la tara que lleva unas décadas siendo comercializado y exportado, según Agraria.pe se exportó en los primeros siete meses del 2022 un total de 7.8 millones de kilos esto representa un aumento del 22% con respecto al año anterior. Los empresarios peruanos parten con una ventaja, ya que la tara es un producto oriundo de nuestro país. Es por ello, que el objetivo principal de esta investigación es determinar la influencia de los programas estatales en el proceso de internacionalización de las empresas peruanas en la región de Lima que comercializan la tara en polvo (14.04.90.20.00) a Brasil en los años 2017 al 2021. Para esto se usó un enfoque cualitativo y se realizó 11 entrevistas a empresas exportadoras, expertos en tara, asociaciones y cooperativas y entidades del estado.