bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Herbal Medicine (Yiqi-Yangyin-Jiedu Decoction) Combined with Osimertinib as First-line Treatment in EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer (CATLA-2): A Study Protocol for a Double-Blind Randomized Controlled Trial
Authors: Yao Jialin , Lu Yan , Jiao Lijing , Bi Ling , Yang Wenxiao , Su Lingzi , Shi Jun , Wang Zhe , Gong Yabin , Xu Ling
Published: January 2022

Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) significantly improve the prognosis of non-small cell lung cancer (NSCLC) with EGFR mutation-positive. Although third-generation EGFR-TKI osimertinib is demonstrated with superior efficacy compared with first-generation EGFR-TKIs, acquired resistance to EGFR-TKIs remains the bottleneck. The Chinese herbal medicine (CHM) Yiqi-Yangyin-Jiedu decoction (YYJD) has been shown to delay acquired resistance to a first-generation EGFR-TKIs in the CATLA study, but there is no high-level evidence for its effect when combined with osimertinib. This trial aims to evaluate the efficacy and safety of YYJD combined with osimertinib as first-line treatment in EGFR mutation-positive advanced NSCLC.Methods: This is a double-blind, multi-center, randomized controlled trial conducted in 8 hospitals in China. A total of 314 participants will be randomly assigned to the osimertinib plus YYJD group (O+YYJD) or the osimertinib plus placebo group (O+placebo). Treatment will last until disease progression or death. Patients diagnosed with advanced NSCLC harboring EGFR Ex19del or L858R will be enrolled if they are in accordance with Qi and Yin deficiency syndrome, ready to take osimertinib as first-line treatment, aged 18 to 74 years old, and provide signed informed consent. The primary outcome is progression-free survival (PFS). The secondary outcomes include a comparison of overall survival (OS), objective response rate (ORR), disease control rate (DCR), and quality of life (QoL). The analysis will be based on intention-to-treat and per-protocol subject analysis principles.Discussion: The goal of this trial is to evaluate the efficacy and safety of YYJD when added to osimertinib as first-line treatment in EGFR mutation-positive advanced NSCLC.Trial registration: Chictr.org.cn ChiCTR1900026748. Registered on 20th October 2019.
Interpreting models interpreting brain dynamics
Authors: Rahman Md Mahfuzur , Mahmood Usman , Lewis Noah , Gazula Harshvardhan , Fedorov Alex , Fu Zening , Calhoun Vince , Plis Sergey
Published: January 2022

Brain dynamics are highly complex and yet hold the key to understanding brain function and dysfunction. The dynamics captured by resting-state functional magnetic resonance imaging data are noisy, high-dimensional, and not readily interpretable. The typical approach of reducing this data to low-dimensional features and focusing on the most predictive features comes with strong assumptions and can miss essential aspects of the underlying dynamics. In contrast, introspection of discriminatively trained deep learning models may uncover disorder-relevant elements of the signal at the level of individual time points and spatial locations. Yet, the difficulty of reliable training on high-dimensional low sample size datasets and the unclear relevance of the resulting predictive markers prevent the widespread use of deep learning in functional neuroimaging. In this work, we introduce a deep learning framework to learn from high-dimensional dynamical data while maintaining stable, ecologically valid interpretations. Results successfully demonstrate that the proposed framework enables learning the dynamics of resting-state fMRI directly from small data and capturing compact, stable interpretations of features predictive of function and dysfunction.
Improving of Global Solar Radiation Forecast by Comparing Other Meteorological Parameter Models with Sunshine Duration Models
Authors: Uçkan irfan , KHUDHUR Kameran Mohammed
Published: January 2022

The solar radiation is affected by many physical factors such as air molecules, water vapor content, dust scattering, and other atmospheric components until it reaches to the earth. Therefore, these factors have negative effects on the measurement of sunshine duration. The aim of this study is to compare sunshine duration based models and the other meteorological parameters based models, and to develop new forecasting models. The estimation and comparison of global solar radiation has been made by using twenty four empirical models including three new models for different location named Arbil, Dohuk, and Sulaimania of Northern Iraq. The reason of using these different locations is to test the accuracy of the other meteorological parameters models by comparing the sunshine duration models for different region. Mostly common statistical errors values are used to evaluate the performance of the estimation models and to identify the models that will give the closest results to the actual values. According to the results, it was seen that the models based on other meteorological parameters has better predictions than the models based on the sunshine duration. While the R2 value of the best models depending on the sunshine duration ranged from 0.97 to 0.99, the R2 values of the best models of other meteorological parameters are above 0.99. Furthermore, it is observed that the new proposed models provide better estimates of global solar radiation at different locations than all models used in this study.
Application of FMEA for Assessment of the Polymer Composite Materials Quality
Authors: Rudenko S. , Berladir K. , Trojanowska J. , Varenyk S. , Shvetsov D. , Kravets V.
Published: January 2022

The paper is devoted to developing a methodology for failure mode and effects analysis on the example of assessment of defects that occur during production and operation of polymer composite materials and industrial products from them. The paper uses the Ishikawa method to illustrate and further analyze the cause of defects in reinforced polymer composite material. The Ishikawa diagram was constructed and analyzed using the method of causal analysis. The types and consequences of failures and defects for polymer composite materials are analyzed. For each type of defect, the value of the priority number of risks is calculated. For the most critical defect, measures to reduce potential defects are proposed. Suggestions for improving the detected defective zones in the structures of polymer composites in the analysis process are given.
Analysis of territories marketing activities among small and medium business: a bibliometric analysis
Authors: Khomenko Liliia , Rosokhata Anna , Jasnikowski Adam
Published: January 2022

The article summarizes the arguments and counterarguments in the scientific discussion on place marketing. The study's main purpose is to understand the nature and features of existing research on marketing areas to determine the direction of future research for both scientists and practitioners. Systematization of literature sources and approaches to solving the problem of marketing areas suggests that many studies in this area require a synthesis of existing research. The urgency of solving this scientific problem is that although the use of marketing in public administration has intensified in recent years, there are many problems in this area. The research of place marketing was carried out in the following logical sequence: determination of the impact of the authors, journals, and articles on territorial marketing, keyword analysis, identification of marketing clusters, visualization of scientific literature on place marketing. The study covers 1970-2021. The research object is 1611 relevant publications published in various scientific sources. The most influential journals were found to be the Journal of Business Research, Tourism Management and Marketing Theory. The most cited authors were Kavaratzis M. and Warnaby G. Most of the articles have been published by researchers from the USA, England, Italy, Canada, the Netherlands, Germany, Australia, and France. Eight key clusters were identified in the marketing of territories: politics, tourism, model, identity, place branding, residents, framework, city brand. In the last five years, most research has been devoted to placing brands, destination marketing, geographies, politics, culture, place branding, identity, tourism, involvement, governance, impact, smart city, loyalty, community. Areas of future research could include destination brand, technology, regeneration, legitimacy, experiences, word-of-mouth, attitude, reflections, memory, inequity of cities, inclusive place branding, brand equity, place attachment, place identity, and others. It is also recommended to focus on city-twinning, sister city, municipal cooperation. The study results could be helpful for companies involved in developing the brand of territories, local authorities for the development of place marketing, and scientists researching place marketing.
Measuring business process innovations among tourism enterprises in the Czech Republic: a PLS-GLM approach
Authors: Dey Sandeep Kumar , Vaculcikova Zuzana , Tuckova Zuzana
Published: January 2022

The Czech Republic has experienced momentous tourism expansion in recent years. Nevertheless, there is a lack of empirical investigation about this development. Innovations are an essential factor for the sustainable development of the tourism industry in the Czech Republic. The paper expounds on the effect of technical and process innovations among the tour and travel companies in the Czech Republic. The study surveyed 96 travel and tour operators aged 18-40 working in the various small, medium, and large travel agencies to determine their perceptions towards innovation in their respective travel businesses. A two-phased statistical process that combined PLS-SEM and GLM examined the responses of the individuals. It revealed that technical innovation had a robust and positive relationship with corporate profitability. Process innovation remains a grey area for Czech travel businesses. The study builds upon the Process Innovations in Colombia's Tourist Enterprises or PICTE framework to induct critical insights for travel agencies and tour operators to provide these businesses a way forward and make them more competitive and sustainable. It has been observed that tourism businesses that were not early adopters of disruptive technologies became vulnerable to market mechanisms. Therefore, the relevance of this study is further accentuated. COVID-19 has accelerated the climate of VUCA (volatility, uncertainty, complexity, and ambiguity) among Czech tour and travel operators, many of whom winded up or downsized operations. Many of these firms were in the medium and small segments. In light of the present situation, it becomes imperative that travel service providers invest in modern technologies and ensure the same diffusion among the staff. The paper gave the strategies towards human resource mapping and digital transformations for the best interest of the tourism industry. Future studies are recommended to focus on longitudinal measures towards understanding innovation propensities among small and medium-sized businesses. Mixed method studies are encouraged to comprehend the corporate dynamics of change management.
Growth, Gas Exchange, and Mineral Nutrients of Hydrangea Hybrids Irrigated with Saline Water
Authors: Sun Youping , Niu Genhua , Dou Haijie , Perez Christina , Alexander Lisa
Published: January 2022

Hydrangeas are popular landscape plants that are widely grown in many parts of the world. The objective of this study was to evaluate the salinity tolerance of three novel Dichroa ×hydrangea hybrids [Dichroa febrifuga ‘Yamaguchi Hardy’ × Hydrangea macrophylla ‘Hamburg’ (YH × Hamburg), Dichroa febrifuga ‘Yellow Wings’ ×Hydrangea macrophylla ‘Nigra’ (YW × Nigra), and Dichroa febrifuga ‘Yellow Wings’ ×Hydrangea macrophylla ‘Oakhill’ (YW × Oakhill)]. A 52-day greenhouse study was conducted by irrigating container-grown plants with nutrient solution at an electrical conductivity (EC) of 1.1 dS·m−1 (control) or saline solution at an EC of 5.0 dS·m−1 (EC 5) or 10.0 dS·m−1 (EC 10). At harvest, YH × Hamburg and YW × Nigra in EC 5 and EC 10 still exhibited good quality with average visual scores greater than 4.1 (0 = dead; 5 = excellent). For YW × Oakhill, moderate foliar salt damage was observed with an average visual score of 2.9 in EC 5 and 2.2 in EC 10. Compared with control, the shoot dry weight of YH × Hamburg, YW × Nigra, and YW × Oakhill in EC 5 reduced by 35%, 35%, and 55%, respectively, whereas that in EC 10 decreased by 58%, 58%, and 67%, respectively. Elevated salinity also decreased plant height, leaf area, and leaf greenness [Soil Plant Analysis Development (SPAD) readings]; chlorophyll fluorescence (Fv/Fm); performance index (PI); and net photosynthetic rate (Pn). All these responses might result from excess accumulation of sodium (Na+) and chloride (Cl−) ions in hydrangea leaves. In this study, compared with control, leaf Na+ concentration of YH × Hamburg, YW × Nigra, and YW × Oakhill increased 11, 36, and 14 times, respectively, in EC 5, and 31, 53, and 18 times, respectively, in EC 10. Compared with control, leaf Cl− concentration increased 4, 9, and 7 times in EC 5, and 10, 11, and 8 times in EC 10 for YH × Hamburg, YW × Nigra, and YW × Oakhill, respectively. Leaf nitrogen (N), phosphorous (P), potassium (K+), and iron (Fe3+) concentrations decreased at elevated salinity levels but did not cause any nutrient deficiency. In summary, the three Dichroa ×hydrangea hybrids exhibited different salinity tolerance: YH × Hamburg and YW × Nigra were more tolerant than YW × Oakhill. Salt-tolerant hydrangea hybrids should be chosen for landscape use if soil and/or irrigation water are salty.
Zihin Yetersizliği Olan Öğrencilere Fen Öğretimine İlişkin Türkiye’de Yapılan Çalışmaların İncelenmesi
Authors: TÜRKER YILDIRIM Çiğdem
Published: January 2022

Giriş: Zihin yetersizliği olan öğrencilerin öğrenme hızları, tipik gelişim gösteren akranlarına göre daha yavaş gerçekleşmektedir. Bu nedenle öğrenme-öğretme sürecinin etkili bir şekilde gerçekleştirilmesi için öğrencilerin bireysel farklılıkları, gelişimsel özellikleri ve eğitim ihtiyaçları doğrultusunda farklı müdahaleler kullanılmalıdır. Bu araştırmanın amacı da zihin yetersizliği olan öğrencilere fen kavram, bilgi ve becerilerinin öğretilmesi için kullanılan müdahalelerin yer aldığı, Türkiye’de gerçekleştirilmiş olan çalışmaların incelenmesidir.Yöntem: Doküman analizi kullanılarak gerçekleştirilen bu araştırmada Google Akademik, Yükseköğretim Kurulu Ulusal Tez Merkezi ve Türkiye Bilimsel ve Teknolojik Araştırma Kurumu Ulusal Akademik Ağ ve Bilgi Merkezi veri tabanlarında tarama yapılmış ve ölçütleri karşılayan 17 çalışma incelenmiştir.Bulgular: Araştırma sonucunda çalışmalarda ortaokul düzeyindeki katılımcılara ve “canlılar ve yaşam” konu alanına daha çok yer verildiği ortaya çıkarılmıştır. İncelenen çalışmaların çoğunda, doğrudan öğretim yöntemi ve teknoloji destekli öğretim müdahalelerinin yer aldığı bulgusu elde edilmiştir. Ayrıca çalışmaların büyük çoğunluğunda öğrencilerin fen kavram, bilgi ve becerileri kazandığı, fen bilimleri dersine yönelik yeterlik ve başarısının arttığı, gerçekleştirilen çalışmaların ilgi ve tutumlar üzerinde olumlu yönde değişim sağladığı bulunmuştur.Tartışma: Araştırmaya dahil edilen çalışmalardan elde edilen bulgular, fen kavram, bilgi ve becerilerinin zihin yetersizliği olan öğrencilere kazandırıldığını göstermektedir. Bu doğrultuda öğrenme hızları tipik gelişim gösteren akranlarına göre daha yavaş olan zihin yetersizliği olan öğrencilerin, bireysel farklılıkları, gelişimsel özellikleri ve eğitim ihtiyaçları doğrultusunda gerçekleştirilen müdahalelerle, etkili bir öğrenme-öğretme süreci gerçekleştirdikleri görülmektedir. Ayrıca zihin yetersizliği olan öğrencilere fen öğretimi amacıyla farklı müdahalelerin uygulandığı, bu müdahalelerin etkililiğinin incelendiği çalışmaların gerçekleştirildiği, dolayısıyla bu çalışmaların zihin yetersizliği olan öğrencilere fen öğretimine yönelik, etkili müdahalelerin ortaya çıkarılması açısından önemli olduğu düşünülmektedir.
Riesgo biomecánico por sobrecarga estática y presencia de trastornos musculoesqueléticos en odontólogos durante su práctica clínica asistencial. Una revisión narrativa
Authors: Agredo Silva Vicenzo Vicente , Arias-Arango María Camila , Villegas- Monsalve Juliana , Zapata-Ortega Natalia , Zapata-Martínez Ricardo Sergio , Zuluaga-Tamayo Mariana
Published: January 2022

Los trastornos musculoesqueléticos son lesiones que afectan el movimiento corporal, incluyendo músculos, tendones, ligamentos, entre otros. Estos trastornos son unos de los problemas más importantes en la práctica clínica odontológica, ocasionados en su mayoría por sobrecarga física tanto dinámica como estática, en particular para esta última, toma relevancia la postura mantenida en posición bípeda o sedente durante la realización de procedimientos extremadamente precisos en un espacio de trabajo tan pequeño como lo es la cavidad oral; por esto, se pretende con base en la literatura existente, describir el riesgo biomecánico por sobrecarga estática y los trastornos musculoesqueléticos en odontólogos. Con esta intención se realizó una revisión narrativa de la literatura científica al respecto en español e inglés de productos de investigación de los últimos diez años, utilizando descriptores DeCS y MeSH, en fuentes académicas y científicas de Pubmed, Medline, Scopus y Google académico en donde se seleccionaron 50 artículos teniendo como resultado principal que si existe una relación entre riesgo biomecánico y sobrecarga estática con la aparición de trastornos musculoesqueléticos.
Posición condílea según biotipo facial en tomografía de haz de cono
Authors: Marin Estrada Melissa , Franco-Valencia Yenni , Puerta-Salazar German , Gutierrez-Quiceno Bruno
Published: January 2022

Introducción y objetivo: La posición condilar, como el biotipo facial es importante para mantener una oclusión y un sistema estomatognático equilibrado. El objetivo del presente artículo es relacionar el biotipo facial con la posición condílea en tomografía de haz de cono, en pacientes sin reporte de trastornos temporomandibulares. Materiales y métodos: Se estudiaron 59 tomografías de pacientes 23 de sexo masculino y 36 femenino, con edades entre 14 y 59 años, se clasificaron en dolicofacial, mesofacial y braquifacial. Con el fin de evaluar la posición condilar se estudió la dimensión de los espacios articulares. Las tomografías fueron medidas con I-Cat vision y para el análisis estadístico se utilizó STATA 14, fue avalado por el comité de ética de la Universidad del Valle. Resultados: Se realizó correlación interobservador obteniendo un Kappa promedio de 0,85. 45 pacientes corresponden al biotipo braquifacial, 8 dolicofacial y 6 mesofacial. En todos los espacios articulares, los braquifaciales presentaron valores de mayor dimensión y el dolicofacial menor dimensión. Se encontró que los espacios mediales (CMS) presentaron valores similares en cuanto a lateralidad dentro de cada biotipo, teniendo diferencias de 0,02 a 0,09 sin embargo, para los espacios articulares centrales (CCS) y laterales (CLS) se observaron mayores diferencias entre un lado y otro, teniendo diferencias 0,15 hasta 0,62 lo cual es estadísticamente significativo. CLS fue el espacio articular de menor dimensión en todos los biotipos. Evaluando los espacios articulares por cada biotipo se encontraron diferencias significativas (P < 0,05) en CMS derecho, CCS derecho y muy cercano a la significancia CLS izquierdo. En todos los espacios articulares se observaron valores mayores en el sexo masculino de los cuales todos son braquifaciales siendo estadísticamente significativa (P < 0,05) para el espacio articular en CCS derecho, CLS Derecho y CLS Izquierdo. Conclusiones: Las dimensiones de los espacios articulares están relacionados con el biotipo facial, las medidas tomográficas de corte coronal son un insumo necesario como parte del análisis y diagnóstico anidado al biotipo facial.
Inclusión de la práctica colaborativa interprofesional para la promoción y prevención de la salud bucal
Authors: Álvarez-Cruces Debbie Jeinnisse , Flores-Cartes Raúl , Sanhueza-Lesperguer Elizabeth
Published: January 2022

Las actividades de promoción y prevención en Salud son relevantes en la Atención Primaria; no obstante, las relacionadas con el Programa de Salud Oral, en Chile, aparecen asociadas a los programas preventivos y no formando parte de ellos, situación que también ocurre en otros países. La presente revisión tiene como objetivos evidenciar las actuales políticas y lineamientos internacionales que indican que se debe propender a una Práctica Colaborativa Interprofesional para una mejor calidad en la atención; y proponer un trabajo interprofesional donde las acciones de promoción y prevención en Salud Bucal se incluyan en los programas preventivos existentes. La Práctica Colaborativa Interprofesional ocurre cuando los miembros del equipo de salud se organizan, planifican, gestionan y proporcionan servicios integrales de salud, evitando la fragmentación de los cuidados. Esto se logra estructurando las competencias comunes, colaborativas y específicas. El trabajo interdependiente permite complementar conocimientos y habilidades que contribuyen a cumplir con las políticas de Calidad de la Atención y Triple Meta en salud. De modo que, se proponen estrategias de trabajo en promoción y prevención de Salud Bucal a incorporar y ejecutar en los diversos programas preventivos ya existentes a lo largo del ciclo vital. En conclusión, es necesario un cambio de paradigma en la atención bucodental donde el foco ya no esté en el programa sino en el individuo, familia y comunidad para lograr una salud integral. Resulta relevante compartir experiencias de atención interprofesional y a incorporar la Educación Interprofesional y Practica Colaborativa en el proceso formativo de las futuras generaciones.
THE ADEQUACY OF THE TRANSFER OF REALITIES AND DEVIATION FROM THE STANDARDS IN A COMPLEX MULTI-STAGE TRANSLATION
Authors:   Baku Slavic University, AMRAKHOVA RENA FIRUDIN
Published: January 2022

This article considers one of the least studied types of translation, namely multi-stage translation, which determines the relevance of the chosen topic. The article is innovative in nature, as it is saturated with new material and thus has a more modern character. The works of prominent Russian and European linguists listed in the article, who were more or less engaged in this problem, as it turns out, were written in the 1970s and 1980s and relied on the technological capabilities of those long-ago years. The article is divided into a number of points, or steps, which reflect the individual and successive stages of the translator's work. Each stage is followed by a small comment, and then it is expanded in terms of the execution of the corresponding actions by the translator. Each of the functions described in the article corresponds to the above points in its internal content. This is the responsibility of a specialist for an extremely accurate (adequate) translation of the title of the work. Then the correct recognition of individual tokens and expressions. Then the search for equivalents for metaphors, idioms and some other types of tropes follows along the chain. A well-known place in the article is also occupied by the theory of transferring individual words from one column to another in order to correct mistakes previously made by the translator. The article is enriched by the fact that the evidence system relies on modern translations. Thus, three novels of the prominent Azerbaijani writer Chingiz Abdullayev, "The Court of the Wrong", "His True Passion" and "The Valor of Giants", translated in 2018, came into view. Moreover, in each case, a translator is specified, so that the examples are taken from these works and thereby concretize both the text itself and indicate the intentions of specialists.
POLYVALENT STATUS OF MODERN LINGUISTICS
Authors:   Astrakhan State Medical University, GUSHCHINA K.N.
Published: January 2022

The article is devoted to an attempt to comprehend the general state of modern linguistic science, as well as to identify and describe the fundamental trends in the development of the science of language. The paper suggests that the removal of information barriers between sciences gives a powerful impetus for the development of research. The dominant linguistic and cognitive-discursive toolkit of a literary work, which determines the originality of the textual projection of the thinking of the subject of speech and receives a specific linguistic formulation of knowledge about the world in a discursive structure. Thus, the article presents a hypothesis according to which the union of linguistics with scientific branches, fundamentally far from it, of a non-humanitarian sense, allows not only to establish linguo-cognitive patterns of representation of the linguistic model of the world, but also to reconstruct the abstract thinking model of the subject of speech.
TO THE QUESTION ABOUT THE PRINCIPLES OF THE CLASSIFICATION OF TOPONYMS
Authors:   Astrakhan State Medical University, ROMANOVA I.V. , KONNOVA O.V. ,   Astrakhan State Medical University
Published: January 2022

Toponyms represent language units denoting elements of topographic environment. Toponymy is a bridge connecting geography and linguistics. The study of this kind of terms requires not only knowledge of the history of the emergence of geographical objects, but also the linguistic features of the language. The relevance of the study is caused by the need to develop the theory of toponymy and to systematize all the existing toponymic classifications. Classifying toponymic nominations, one must consider the multifaceted (intra- and extra-linguistic) principles of allocation of toponymic units. This article examines the classifications of foreign authors, proposed in various historical periods, personifying views on the problems of typologization of toponyms.
SUSPENSION POINTS AND ITS FUNCTIONS IN THE TRANSLATION OF A POETIC TEXT
Authors:   Astrakhan State University, SVESHNIKOVA M.I. , SERNOVA E.I. ,   Astrakhan State University
Published: January 2022

The article is devoted to the problem of the transfer of such punctuation mark as suspension points in the translation of a poetic text from French into Russian. Examples of translations of French poetic texts from classics to modern works are analyzed. The role of the suspension points is shown in the process of changing the rules of the organization of poetic speech.
COMMUNICATIVE-COGNITIVE POTENTIAL OF RUSSIAN LANGUAGE IN THE ANTHROPOCENTRIC SPACE OF INOPHONES
Authors:   Astrakhan State University, GOLOVANEVA M.A. , KASYANOVA L.YU. ,   Astrakhan State University
Published: January 2022

The article examines the results of research carried out on the basis of the analysis of speech activity of foreigners, and concludes that the inevitable gradual transformation of the anthropocentric space of the speech producer due to the realization of its communicative and cognitive potential by the Russian language. Observations of the results of extra-curricular speech work, which has a linguistic, linguistic and cultural and linguistic-cultural nature, as well as the analysis of the speech-and-text of foreign phones to identify the specifics of key concepts, led to the idea that the changing picture of the world of the foreigner acquires the features of Russianness. At the same time, the foreign language receives the opportunity to observe the mental transformative activity of the language, the manifestation of its vitality, the real influence on the thought and feeling of a person. The research results expand the information field of cognitive science and cultural linguistics.
ABOUT SEMANTIC GRADATION AND FUNCTIONS OF MEDICAL TERMS IN ARTISTIC DISCOURSE (IN POETIC TEXTS)
Authors:   Astrakhan State Medical University, MOTYGINA ZH.YU.
Published: January 2022

The article analyzes the use of medical terminology in poetry of the Soviet period (20-70s of the XX century). Consideration of the texts of such poets as E. Asadov, A. Voznesensky, M. Tsvetaeva, B. Pasternak allows us to see the different degrees of determinologization of medical vocabulary in the structure of artistic discourse. The article shows that medical terms easily enter the composition of metaphors, occasionalisms, neologisms, acquire new connotative and emotive shades of meaning. Terms and medical vocabulary are capable of performing nominative, characterological functions, forming a creative reality - a picture of the world of a particular work, and contributing to the creative self-expression of poets. The article uses the techniques of the structural-semiotic method and conceptual analysis.
Determining factors of the intention to adopt fintech services by micro and small business owners from Chiclayo, Peru
Authors: Merino Balcázar Janella Jhojani , Llatas Rivas Ángel Eduardo
Published: January 2022

The objective of this research was to determine the factors that influence the intention to adopt fintech services by micro and small business owners from Chiclayo; for this purpose, an applied quantitative study was carried out in which the extended technology acceptance model proposed by Hu, Ding, Li, Chen and Yang (2019) was used for the analysis of nine variables related to the adoption of these technologies. The results reaffirmed that most of the constructs included in the conceptual model have great explanatory power regarding the adoption intention of fintech services, in that 11 of the 13 hypotheses were proven. Thus, it was demonstrated that business owners from Chiclayo use a new technology mainly under the influence of factors such as trust, brand image, and perceived utility, while also considering the potential risks to which they may be exposed; together, these considerations influence their attitude toward adopting fintech services. Finally, the analysis showed that government support and perceived ease of use have only a limited effect, while user innovativeness was the only factor that turned out to be non-significant in the intention to adopt this kind of services.
O impacto do uso da tecnologia no desempenho da produção leiteira: manejo tradicional, compost barn e free stall
Authors: Meinl Ana Maria , Paveglio Vieira Euselia
Published: January 2022

Objetivo: Esta aplicação teórica busca analisar a contribuição do uso de tecnologias e sistemas de produção diferenciados na formação dos resultados da atividade leiteira de três propriedades rurais, que utilizam diferentes sistemas produtivos e estão localizadas na região Noroeste do Estado do Rio Grande do Sul. Utilizou-se para a apuração de custos das três propriedades o método de custeio por absorção e variável, afim de conhecer os respectivos resultados em cada sistema de produção analisado.

Metodologia: Para atingir o objetivo do estudo, foram elaboradas, a partir da coleta de dados planilhas de controle financeiro, e com base nestas, apurou-se os indicadores gerenciais de custos de cada propriedade, sendo eles: margem de contribuição, ponto de equilíbrio, margem de segurança operacional, demonstração do resultado e alguns indicadores de investimentos, possibilitando assim a comparação dos resultados na produção tradicional, compost barn e free stall.

Resultados: Os resultados indicam que o método compost barn obteve a maior produtividade por matriz, o maior preço médio e o segundo menor custo por litro, e, portanto, o maior lucro médio por litro e por área (hectare) destinado a produção leiteira entre as três propriedades analisadas, sendo seu resultado médio por litro de R$ 0,27 e por área (hectare) R$ 10.030,52. Em comparação com outros estudos realizados na área, os resultados indicam que a região em pesquisa foi um fator determinante.

Contribuições do Estudo: A pesquisa possibilitou aos usuários externos verificar qual método de produção alcançou maior produtividade e lucratividade na região e nas propriedades analisadas. Além disso, para os produtores participantes da pesquisa, permitiu avaliar o retorno da atividade a partir de uma completa apuração de custos, tendo em vista que seus controles antes do desenvolvimento do estudo eram fortemente baseados na intuição ou em experiências anteriores, sem um devido controle e avaliação.
Management of a Hot Swollen Joint in the Acute Setting
Authors: Zhou Andrew Kailin , Ho Jamie Sin Ying , Tran Caitlyn , Jou Eric , Girish Milind , Thahir Azeem , Chabra Shirom , Hussain Hassan Abbas
Published: January 2022

Background:

The presentation of a hot swollen joint is common in the emergency department,
general practice, rheumatology and orthopedic clinics. There is a wide set of differential
diagnoses for a hot swollen joint, thus making it difficult to diagnose and manage, especially for junior
doctors. Initially, it is pertinent to exclude/diagnose medical and surgical emergencies.

Objective:

This paper aims to summarize the key indications within the history, examination and investigations
in order to quickly and effectively diagnose a hot swollen joint based on the original
2006 management guidelines and the papers discussing other possible indications and management
strategies published since then.

Results:

Currently, the management of crystal and non-infectious arthropathies is well recognized
with little disparity. However, the treatment of infectious arthritis is not concrete, and there are discrepancies
in management between doctors.

Conclusion:

We have summarized the key indications and provided a diagnostic flow chart to aid
with the management of a hot swollen joint.
Мультикалорики --- новые материалы энергетики и стрейнтроники -=SUP=-*-=/SUP=- (О б з о р)
Authors: Амиров А.А. , Тишин А.М. , Пахомов О.В.
Published: January 2022

The terms "multicaloric effect" and "multicaloric" are relatively new concepts and combine the phenomena and materials associated with the coexistence of conventional caloric effects under the action of external forces of various nature (magnetic field, electric field, mechanical action). Nowadays, caloric materials remain in the focus of attention of researchers, and approaches based on the use of the multicaloric effect are considered as one of the ways to improve the efficiency of conventional solid-state cooling systems. Of particular interest from a fundamental point of view are the cross effects observed under the combined external stimulus, as well as the nature of the relationship between magnetic, electrical, thermophysical properties and structure under such actions.
In this review, the theoretical foundations of the multicaloric effect are considered and an attempt is made to systematize multicaloric materials. Applied aspects of multicalorics are considered separately, and various experimental approaches to the study of their properties are presented. The presented review will be of interest to a wide range of specialists involved in the study of materials with caloric effects (magnetocaloric, electrocaloric, mechanocaloric), as well as those who are searching for new functional materials.
Decision-making for Parents of Children With Medical Complexities: Activity Theory Analysis
Authors: Buchanan Francine , Lai Claudia , Cohen Eyal , Milo-Manson Golda , Shachak Aviv
Published: January 2022

Background

Shared decision-making (SDM), a collaborative approach to reach decisional agreement, has been advocated as an ideal model of decision-making in the medical encounter. Frameworks for SDM have been developed largely from the clinical context of a competent adult patient facing a single medical problem, presented with multiple treatment options informed by a solid base of evidence. It is difficult to apply this model to the pediatric setting and children with medical complexity (CMC), specifically since parents of CMC often face a myriad of interconnected decisions with minimal evidence available on the multiple complex and co-existing chronic conditions. Thus, solutions that are developed based on the traditional model of SDM may not improve SDM practices for CMCs and may be a factor contributing to the low rate of SDM practiced with CMCs.

Objective

The goal of our study was to address the gaps in the current approach to SDM for CMC by better understanding the decision-making activity among parents of CMCs and exploring what comprises their decision-making activity.

Methods

We interviewed 12 participants using semistructured interviews based on activity theory. Participants identified as either a parent of a CMC or a CMC over the age of 18 years. Qualitative framework analysis and an activity theory framework were employed to understand the complexity of the decision-making process in context.

Results

Parents of CMCs in our study made decisions based on a mental model of their child’s illness, informed by the activities of problem-solving, seeking understanding, obtaining tests and treatment, and caregiving. These findings suggest that the basis for parental choice and values, which are used in the decision-making activity, was developed by including activities that build concrete understanding and capture evidence to support their decisions.

Conclusions

Our interviews with parents of CMCs suggest that we can address both the aims of each individual activity and the related outcomes (both intended and unintended) by viewing the decision-making activity as a combination of caregiving, problem-solving, and seeking activities. Clinicians could consider using this lens to focus decision-making discussions on integrating the child’s unique situation, the insights parents gain through their decision-making activity, and their clinical knowledge to enhance the understanding between parents and health care providers, beyond the narrow concept of parental values.
Decision-making for Parents of Children With Medical Complexities: Activity Theory Analysis (Preprint)
Authors: Buchanan Francine , Lai Claudia , Cohen Eyal , Milo-Manson Golda , Shachak Aviv
Published: January 2022

BACKGROUND

Shared decision-making (SDM), a collaborative approach to reach decisional agreement, has been advocated as an ideal model of decision-making in the medical encounter. Frameworks for SDM have been developed largely from the clinical context of a competent adult patient facing a single medical problem, presented with multiple treatment options informed by a solid base of evidence. It is difficult to apply this model to the pediatric setting and children with medical complexity (CMC), specifically since parents of CMC often face a myriad of interconnected decisions with minimal evidence available on the multiple complex and co-existing chronic conditions. Thus, solutions that are developed based on the traditional model of SDM may not improve SDM practices for CMCs and may be a factor contributing to the low rate of SDM practiced with CMCs.

OBJECTIVE

The goal of our study was to address the gaps in the current approach to SDM for CMC by better understanding the decision-making activity among parents of CMCs and exploring what comprises their decision-making activity.

METHODS

We interviewed 12 participants using semistructured interviews based on activity theory. Participants identified as either a parent of a CMC or a CMC over the age of 18 years. Qualitative framework analysis and an activity theory framework were employed to understand the complexity of the decision-making process in context.

RESULTS

Parents of CMCs in our study made decisions based on a mental model of their child’s illness, informed by the activities of problem-solving, seeking understanding, obtaining tests and treatment, and caregiving. These findings suggest that the basis for parental choice and values, which are used in the decision-making activity, was developed by including activities that build concrete understanding and capture evidence to support their decisions.

CONCLUSIONS

Our interviews with parents of CMCs suggest that we can address both the aims of each individual activity and the related outcomes (both intended and unintended) by viewing the decision-making activity as a combination of caregiving, problem-solving, and seeking activities. Clinicians could consider using this lens to focus decision-making discussions on integrating the child’s unique situation, the insights parents gain through their decision-making activity, and their clinical knowledge to enhance the understanding between parents and health care providers, beyond the narrow concept of parental values.
Navigating the Systemic Conditions of a Digital Health Ecosystem in Alberta, Canada (Preprint)
Authors: Saunders William Chad , Currie Devon , Virani Shane , De Grood Jill
Published: January 2022

BACKGROUND

Digital health promises numerous value-creating outcomes. These include improved health, reduced costs, and the creation of lucrative markets, which in turn provide high quality employment, productivity growth, and a climate that attracts investment. For this value creation and capture to occur, the activities of a diverse set of stakeholders within a digital health ecosystem need coordination. However, the antecedents the coordination needed for an effective digital health ecosystem are not well understood.

OBJECTIVE

The purpose of this study is to investigate the systemic conditions of the digital health ecosystem in Alberta, Canada as critical antecedents to ecosystem coordination.

METHODS

We employed a qualitative case study of the systemic conditions within the digital health ecosystem in Alberta, Canada using semi-structured interviews with 36 stakeholders representing innovators-entrepreneurs, health system leaders, support partners, and funders. Data were coded for key themes and synthesized around five propositions.

RESULTS

The findings indicate varying levels of support for each proposition, including accessing real problems, data, training, and space for evaluations. However, the most foundational gap appears to be in ecosystem navigation. In particular, the absence of intermediaries to provide guidance on available support services and dependencies among the various ecosystem actors and programs.

CONCLUSIONS

Navigating the systemic conditions of the digital health ecosystem is extremely challenging for entrepreneurs without prior healthcare experience, and this remains an issue even for those with such experience. Policy interventions aimed at increasing collaboration among ecosystem support providers, along with tools and incentives to ensure coordination, are essential as the ecosystem grows.
Review on Mobile Application Development Based on Flutter Platform
Authors: Bhagat Shreya A.
Published: January 2022

Abstract: Covid-19 pandemic has made mobile applications very popular. There is a huge competition between many mobile application development frameworks available in the market. In today’s world ease of development is the thing all developers are seeing for and flutter has come with the required platform to support development of applications for both iOS and Android platforms, consequently decreasing the cost and complexity of application creation across both platforms. Flutter is the crossplatform mobile application development open-source SDK tool for developing high-performance and more reliable mobile applications for iOS and Android operating systems. This paper has been undertaken to indicate the benefits of using flutter over other app development platforms. Keywords: Cross-Platform Mobile Application, Flutter, Dart, GetX State Management, Firebase
PURIFICATION, EXTRACTION OF SEMECARPUS ANACARDIUM BY TRADITIONAL METHOD AND EVALUATION OF ANTIBACTERIAL ACTIVITY
Authors: Bandigari Parijatha
Published: January 2022

In Indian system of medicine marking nut is one among the medicinal plants used to cure many diseases like inflammation, piles, and cancer. In this method marking nut extraction is done by using simple traditional method without using solvent. This method is completely free from chemical effect. The antimicrobial activity of the extract was determined by Agar Disc diffusion method against Gram positive and gram negative bacteria. MIC values about Staphylococcus aureus, Escherichia coli, Lactobacillus were 10, 20, and 40 mg/ml respectively. This study can provide information for the future research to determine antimicrobial activity.
REMOTE REHABILITATION OF THE POST-STROKE PATIENTS WITH THE HAND AND FINGER NERVES DAMAGED THROUGH WIRELESS DEVICES IN INDIVIDUAL CONDITIONS
Authors: Zhuravska Iryna M
Published: January 2022

After the stroke, the hand nerves, the motor and/or sensory functions are impaired, especially fine motor skills of each finger individually or a group of fingers. Previous studies have shown that the combination of various methods, e.g., medication, physical therapy, as well as exercises to strengthen muscles and restore fine motor skills with personal small-sized automatized devices are effective. In the paper is proposed a method of constructing a “green zone” (optimal for patient training mode), and “red zone” (dangerous training mode), which correspond to the model of quantitative dependence the time fulfill several sequential actions patient based on the moving average. A decrease of muscle spasticity of the arm in scores following the Modified Ashworth Scale (MAS) was used as an optimality criterion. For remote rehabilitation of the post-stroke patients in individual conditions the wireless devices of the “Reflex Txx” series were developed, which has in-built Hall sensors or touch sensors. The remote rehabilitation training data are transmitted via a wireless channel (4G or Wi-Fi network), accumulated, and analyzed on the microservices of the developed hardware and software complex. The results of each personal training are displayed on the user's gadgets (smartphone, laptop, etc.) in real-time. Implemented electronic components and architecture of the developed devices are based on a cost-effective Arduino platform hardware. Using of “Reflex Txx” series’ devices, in addition to conventional physiotherapy, gives positive shifts in treatment after only 150 minutes of the entire trial during even short-term (1 week) exercise.
MODELLING OF DYNAMIC SYSTEMS IN STATE SPACE
Authors: Miková Ľubica , Prada Erik , Virgala Ivan , Hroncová Darina
Published: January 2022

This paper deals with the solution of dynamical systems in state space. Complicated differential equations are converted into a simpler form by using state variables in vector matrix. It is used for multi-input and multi-output systems, and the solution is performed using matrix notation. It describes systems with complex internal structure. It allows state models to be manipulated using matrix calculus. Systems described by a state model are characterized by the fact that it is easier to design state control for them.
GEARBOX LUBRICATION SYSTEM OPTIMIZATION
Authors: Maláková Silvia , Sivák Samuel , Krajňák Jozef
Published: January 2022

The aim of gearbox lubrication is to reduce wear on the sides of the teeth, increase of the efficiency by reducing friction as well as dissipating the heat generated by friction. Lubrication of gearboxes is a discontinuous process, that means, during the meshing every meshed pair of teeth needs to have a new lubrication film created on the surfaces. The geometric shape of the sides of the teeth is conditioned by rolling and sliding movement, therefore gears often work under a mixed friction condition. This is confirmed by damage to gearboxes and by measured power losses. This contribution is devoted to the issue of innovation of the original lubrication of the first stage of the bevel helical gearbox used for the drive of the rope drum.
KINEMATIC ANALYSIS OF THE INDUSTRIAL ROBOT EFFECTOR
Authors: Delyová Ingrid , Frankovský Peter , Hroncová Darina
Published: January 2022

The technical level of industrial robots and manipulators is rapidly increasing, thus supporting the expansion of their application space. The requirements of the industry are various special manipulations with objects, guiding the end effector of the robot along the prescribed trajectory at a given speed while maintaining the angular position and orientation of the object. The paper presents a survey of a robot with a kinematic scheme formed by an open kinematic chain with revolute joints.