bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic Viral Hepatitis B and Intestinal Microecology
Authors: Ma Xinyu , Hao Jianmei
Published: October 2024

Hepatitis B is one of the leading causes of chronic liver disease worldwide. After HBV infection, some patients develop chronic hepatitis, and long-term inflammation and fibrosis may lead to cirrhosis and hepatocellular carcinoma. In recent years, the role of gut microecology in liver disease has received widespread attention. The balance of the gut microbial community is essential for maintaining the health of the host immune system, and HBV infection may affect this balance. Based on this, this article investigates hepatitis B-related chronic liver disease and gut microecology for reference.
Bibliometric Analysis of Traditional Chinese Medicine in the Treatment of Asthma from 2005 to 2024
Authors: Huang Jiale , Li Chengyou , Liu Ying , Li Enping , Lei Mingsheng
Published: October 2024

Asthma is a complex chronic respiratory disease that affects most people worldwide and imposes a heavy economic and health burden. Traditional Chinese medicine (TCM) is one of the common treatments for asthma; however, there is a lack of bibliometric analysis data on the relationship between bronchial asthma and traditional Chinese medicine. This study analyzes and visualizes current research status and future trends. Relevant English publications on traditional Chinese medicine treatment for bronchial asthma were collected from the Web of Science core collection, and bibliometric analysis was conducted using software like Histcite. A total of 406 articles meeting the criteria were included after manual screening. China (including Taiwan) emerged as the leading contributor, with the Beijing University of Chinese Medicine being the institution with the highest number of publications. 'Journal of Ethnopharmacology' was a significant publication in this domain. The most frequently occurring keyword on the main display platform was 'airway inflammation.' Future research hotspots are expected to focus on intestinal flora and metabolism. This research offers a fresh perspective for understanding developments in this field.
Der Krankenhaus-EBM
Authors: Klinger-Schindler Ursula , Meier Anja
Published: October 2024

?Der Krankenhaus-EBM? ist die einzige Publikation, die sich neben der Vermittlung der wichtigsten Kenntnisse über die vertraglichen Grundlagen auch mit der praktischen Anwendung der Abrechnung nach dem EBM (Einheitlichen Bewertungsmaßstab) befasst. Es werden alle aktuellen ambulanten krankenhausrelevanten Leistungsbereiche berücksichtigt, die nach dem EBM mit KV und Krankenkassen abgerechnet werden müssen.Neben vielen Tipps und Hinweisen zur Komplexität des Euro-EBM unter der beginnenden Ambulantisierung von Krankenhausleistungen werden auch häufig auftretende Fragestellungen aus der täglichen Praxis berücksichtigt und anhand zahlreicher Abrechnungsbeispiele erläutert.?Der Krankenhaus-EBM? verknüpft die Kernproblematik Krankenkassenreklamation mit allen wichtigen Bestimmungen des EBM, die für eine sachgerechte Auseinandersetzung äußerst hilfreich sind.Gerichte schaffen in der Auslegung zunehmend Klarheit bei Regelungslücken im Gebührenordnungswerk.
Kodier-Manual Krankenhaus 2024
Authors: Schroeders Nikolai
Published: October 2024

Die Kodierung stationärer Krankenhausfälle ist ein zentraler Bestandteil zur Erlössicherung im Krankenhaus. Eine gute Kodierung sichert an einem wichtigen Punkt die Existenz des Krankenhausbetriebes. Kodierdefizite bergen hohe Risiken wirtschaftlicher Ausfälle und erzeugen im Nachgang erheblichen Arbeitsaufwand bei Streitigkeiten zwischen Krankenhäusern und Krankenkassen. Damit kommt den Kodierfachkräften große Bedeutung zu. Allerdings gibt es keine einheitlichen Modelle oder Curricula für deren Ausbildung. Die Erfahrung der Autoren hat gezeigt, dass es immer wieder die gleichen Fragen und Themen sind, die im Alltag der Ausbildung von Kodierfachkräften schwierig sind und zu Missverständnissen führen. Diese Problematik löst das vorliegende Buch, das in der aktuellen Ausgabe auch die Urteile des Schlichtungsausschusses berücksichtigt, die bis zum Zeitpunkt des Druckes veröffentlicht wurden.Angesprochen sind alle Personen, die mit der Kodierung oder der Ausbildung von Mitarbeitern in der Kodierung befasst sind.Dieses Kodier-Manual ist eine perfekte Grundlage zur Anleitung, Ausbildung und Weiterbildung von Kodierfachkräften. Aber auch Ärzte erhalten einen guten Einblick in die Bereiche der Kodierung, die typischerweise zu Streitigkeiten und Diskussionen mit Krankenkassen und MDK führen. Das Kodier-Manual ist also nicht nur das richtige Werkzeug bei der Primärkodierung, sondern auch ein hilfreicher Ratgeber bei Auseinandersetzungen um die Abrechnung.
ocean4Foam (software)
Authors: Kemper Jost
Published: October 2024

Solvers and functionality for oceanic flow in OpenFOAM®.
Trabzon İli Gastronomi Rotaları
Authors: Öztürk Batuhan , Akar Şahingöz Semra
Published: October 2024

Küreselleşen dünya, farklılaşan turist beklentileri ve ihtiyaçları, özel ilgi alanlarına yönelik turizm faaliyetlerinin planlanmasına ve gerçekleştirilmesine sebep olmaktadır. Günümüzde destinasyonların markalaşarak ön plana çıkması ve pazarlanması noktasında alternatif turizm çeşitlerinin başında gastronomi turizmi gelmektedir. Aynı zamanda gastronomi turizm faaliyetlerinde gastronomi rotalarının planlanması ise destinasyon açısından büyük önem taşımaktadır. Buradan hareketle gerçekleştirilen bu çalışmada Trabzon şehrinin gastronomi rotalarının oluşturulması amaçlanmıştır. Bu amaç doğrultusunda Trabzon’da yiyecek içecek işletmeleri, yerel yöneticiler ve turist rehberleriyle yüz yüze görüşmeler gerçekleştirilmiştir. Elde edilen veriler MAXQDA nitel ve karma veri analiz programıyla tematik analiz ve içerik analizine tabi tutulmuştur. Ortaya çıkan sonuçlar ile şehirde gastronomik anlamda ziyaret edilecek noktalar tespit edilmiş ve gastronomi rotaları oluşturulmuştur.
Discourse Analysis of Conflict Talk in The Painted Veil
Authors: TAN Huizhu
Published: October 2024

Conflict talk is one of the most important topics of discourse analysis. This paper, based on the conversations of the film The Painted Veil, is concerned with the sequential organization of conflict talk in the film. Initiating moves, oppositional moves and terminating moves of conflict talks are discussed and analyzed in order to explore how conflict talks show the characteristic of the roles in an art work.
Faktor-Faktor yang Berhubungan dengan Kepemilikan Aplikasi Mobile JKN pada Peserta BPJS Kesehatan di Wilayah Kerja UPT Puskesmas Rawat Inap Ujan Mas
Authors: Angraini Wulan , Pratama Yesa Putri , Yanuarti Riska , Kosvianti Emi , Febriawati Henni
Published: October 2024

ABSTRACT National health insurance provides individuals with health benefits and protection to meet their basic health needs. Health insurance is provided by the government through the Social Security Administering Agency (BPJS), consisting of BPJS Employment and BPJS Health. In order to increase the efficiency of providing health services, BPJS Health introduced the JKN application. This application represents the latest technological advances aimed at increasing individual convenience in accessing services and information at high costs. The aim of the research is to test or validate research hypotheses that answer research problems, while this particular research methodology can be classified as observational research, where researchers make their own observations of variables without any treatment. The research methodology used was a cross-sectional quantitative design with a chi-square test sample of 106 people. Research findings show that there is a significant correlation between knowledge (P Value=0.000), however, there is no significant correlation between gender (P Value=0.568) and ownership of the JKN mobile application. So it can be concluded that knowledge has a relationship, while gender has no relationship with ownership of the JKN mobile application on BPJS Health participants in the UPT Ujan Mas Inpatient Health Center working are.  Keywords: BPJS, Health Services, Mobile JKN  ABSTRAK Asuransi kesehatan nasional memberi individu manfaat maupun perlindungan kesehatan untuk terpenuhinya kebutuhan kesehatan mendasar mereka. Jaminan kesehatan diselenggarakan oleh pemerintah melalui Badan Penyelenggara Jaminan Sosial (BPJS) terdiri dari BPJS Ketenagakerjaan maupun BPJS Kesehatan. Guna meningkatkan efisiensi penyelenggaraan pelayanan kesehatan, BPJS Kesehatan memperkenalkan aplikasi JKN. Aplikasi ini mewakili kemajuan teknologi terkini yang bertujuan untuk meningkatkan kenyamanan individu dalam mengakses layanan dan informasi dengan biaya mahal. Tujuan penelitian ialah menguji maupun memvalidasi hipotesis penelitian yang menjawab permasalahan penelitian, sedangkan metodologi penelitian khusus ini dapat digolongkan sebagai penelitian observasional, dimana peneliti melakukan observasi sendiri terhadap variabel tanpa adanya perlakuan apapun. Metodologi penelitian yang digunakan adalah desain kuantitatif cross-sectional dengan sampel uji chi-square sebanyak 106 orang. Temuan penelitian menunjukkan adanya hasil korelasi yang signifikan antara pengetahuan (P Value=0,000) namun, tidak terdapat korelasi yang signifikan antara jenis kelamin (P Value=0,568) dengan kepemilikan aplikasi mobile JKN. Maka dapat disimpulkan bahwa pengetahuan memiliki hubungan, sedangkan jenis kelamin tidak memiliki hubungan dengan kepemilikan aplikasi mobile JKN pada peseta BPJS Kesehatan di wilayah kerja UPT Puskesmas Rawat Inap Ujan Mas. Kata Kunci: BPJS, Layanan Kesehatan, Mobile JKN
The Fifth Scientific and Practical Conference “The letter and digit: The libraries on the way to digitalization” (“BiblioPiter-2024”)
Authors: Shrayberg Y. L. , Kulikova A. A.
Published: October 2024

The authors review the work of the Fifth Scientific and Practical Conference “The letter and digit: The libraries on the way to digitalization” (“BiblioPiter2024”) held on April 9–11, 2024. The conference subject scope comprised the following topics: The role of libraries in information support of science and education; training staff for specialized, academic and public libraries; AI tools development and use in education; status of and prospects for modern information, computer and Internet-based technologies in library practice; modern library functional transformation. The conference discussions are summarized.
The The Specialties of Sundanese Ngujuban Culture in the Community of Maja District
Authors: Andriyani Nuri
Published: October 2024

Tradisi Budaya Sunda Ngujuban merupakan kegiatan mengarwahkan atau mendatangkan para leluhur. Di dalamnya terdapat penyuguhan berupa sesaji makanan, minuman, jajanan pasar, kembang, rokok, dan pembacaan doa-doa. Bertujuan untuk menghormati dan mengingat para leluhur, serta mensyaratkan keselamatan dan kesejahteraan bagi mereka di alam baka. Budaya ini mengandung moral yang dapat diterapkan di kehidupan sehari-hari.  Metode penelitian ini menggunakan metode kualitatif dengan diperkuat oleh deskriptif yang mewawancarai beberapa narasumber berasal dari Kecamatan Maja. Hasil penelitian ini menunjukkan bahwa Keistimewaan Budaya Sunda Ngujuban terdapat pada pelaksanaannya yaitu satu hari sebelum hari raya dan hajat, dimana para karuhun atau leluhur datang mengunjungi tempat keluarganya masing-masing. Terdapat pembelajaran yang bisa diterapkan berupa (1) Nilai Pendidikan; (2) Nilai Religius; (3) Nilai Sosial; (4) Nilai Spiritual; dan  (5) Nilai Kultural. Dengan adanya pembahasan mengenai Budaya Sunda Ngujuban diharapkan  masyarakat Indonesia khususnya suku Sunda yang belum mengetahui budaya ini bisa menjadi tahu dan menjadikan bahan pembelajaran ilmu mengenai keberagaman yang berada di masyarakat Sunda serta diketahui secara luas juga bermanfaat bagi masyarakat yang lainnya.
Histological Change of Placenta in Diabetic Pregnant Women in Comparison to Normal Pregnant Women
Authors: Khanom Most Ishita , Fariya Saian , Liza Razia Sultana , Smrity Rubaiya Tabassum
Published: October 2024

Background: The placenta is a foeto-maternal organ and its alterations is directly related to the disease’s length and severity. The human placenta experiences a number of functional and structural pathologic alterations when complicated by metabolic disorder such as diabetes mellitus. Methods: This cross-sectional comparative study was conducted over a period of threeyears from January 2019 to December 2021 at the Department of Anatomy, Rajshahi Medical College, Rajshahi, in collaboration with the Department of Obstetrics and Gynaecology, Rajshahi Medical College Hospital and Diabetic Hospital Rajshahi, Bangladesh. The study was carried out on 70 pregnant women, among them 35 diabetics and 35 non-diabetics. The fibrinoid necrosis, syncytial knot and immature villi of the placenta were studied in diabetic and non-diabetic pregnant women. SPSS software, version-24 was used for data analysis, with a p-value < 0.05 indicating statistically significance for all tests. Results: The diabetic and non-diabetic pregnant women groups were almost identical in terms of attachment of umbilical cord to placenta with marginal attachment being more often found in either group (p = 0.829). Histological examination of placenta showed that fibrinoid necrosis was common in placenta of diabetic mothers than that of the normal mothers (p < 0.001). Syncytial knot and immature villi were higher in the former group than those in the latter group, here p values were also less than .001. Conclusion: Histological findings (fibrinoid necrosis, syncytial knot and immature villi) were more in placenta of diabetic mother and they were highly significant different between the groups.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 27-33
Pattern of Musculoskeletal Manifestation in Patient with Diabetes Mellitus
Authors: Faruk Abdullah Al , Shahnewaz Shaila Sharmin , Mojumdar Suman Kanti , Babu Md Asaduzaman
Published: October 2024

Background: Diabetic mellitus (DM) both type 1 and type 2 increasing dramatically throughout worldwide. DM involved all the vital organs including musculoskeletal system. Objective: The purpose of study was to find out patterns of musculoskeletal manifestation (MSM) in diabetic patients & to find out a strategy to improve the outcome of the MS complications in patients with Diabetes Mellitus. Material and Methods: This was hospital based observational study conducted on 143 diabetics patients with musculoskeletal manifestations, both men and women (aged e”15- 70 years) visited in outpatient department and hospital admitted patient in a tertiary care of teaching hospital. Patterns were defined by a meticulous history, relevant general and systemic examination & with the aid of musculoskeletal (MS) Function Assessment semi structured Questionnaire. Results: MSM are common among patients with type 2 diabetes Out of 143 patients in our study 103(72.03%) were Male and 40(27.97%) were female, and male –female ratio 2.57:1. The age distribution of study patients was 15 to 70 years. Overall, 72.03.% of patients were among the 40-59 years old and about 20.28% were 60 years and mean age of the patients was 55±5. Above which is statistically significant (P= 0.048). The shoulder involvement as adhesive capsulitis (frozen shoulder) was found among 69(48.25%) on the diabetic cohort and statistically significant (P= <.05) and mostly among the housewife (27.99%) and manual worker like cultivator (13.99%). Degenerative osteoarthritis was commonly associated with MSM with DM than inflammatory arthritis. Conclusion: In our study shows degenerative, non-inflammatory MSM are common among the diabetic patients that leads to significant pain and disability that directly related with poor glycemic control and co-morbidities like stroke and obesity. Early recognition of these complications, and multidisciplinary management between diabetes and rheumatology specialists is necessary to reduce morbidity.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 66-69
Pattern of Surgical Antibiotic Prophylaxis in a Tertiary Care Hospital of Bangladesh
Authors: Sharif Md Hasan , Karim Md Mafizul , Shawon Galib Md , Shammi Shabrina Shanewaz , Sunnah Hasna Tul Jamiya
Published: October 2024

Background: Surgical Site Infection (SSI) is a common form of hospital-acquired infection and major cause of postoperative illness accounting for approximately a quarter of all nosocomial infections. As a result, surgical antibiotic prophylaxis is now considered essential to conventional surgical procedure in order to reduce surgical site infections and improve postoperative recovery. The misuse and overuse of antibiotics has led to an increase in treatment costs and the emergence of antimicrobial resistance. The goal of the study is to identify the pattern of prophylactic antibiotic prescriptions for different surgical operations. Materials and methods: A retrospective observational study was conducted among 600 patients undergoing different surgeries in a tertiary care hospital of private setting in Dhaka, Bangladesh from July 2023 to December 2023. The demographic data, types of surgery, types of therapy, choice of antibiotic along with dosage formulations were collected. Results: Out of 600 patients, 245 (41%) were male and 355 (59%) were female. Highest bulk of patients were from Department of General Surgery (47.5%), followed by Department of Obstetrics & Gynecology (24.16%) and Department of Otolaryngology (16.7%). Surgical prophylactic antibiotic was used in all 600 patients, and all antibiotics were given in intravenous route (100%). Almost 505 patients (84.2%) had received ceftriaxone as antimicrobial agent. Ceftriaxone with metronidazole or gentamicin and Cefuroxime with metronidazole or amikacin drugs combination were given to 75 (12.5%) and Cefuroxime, Amikacin, Metronidazole drugs combination were given to 20 patients (3.3%). 3rd generation cephalosporin, Ceftriaxone, was the most commonly prescribed antibiotic as monotherapy (94.3%), followed by 2nd generation cephalosporin, cefuroxime (4%). Conclusion: Ceftriaxone was the preferred antibiotic for surgical prophylaxis. Existence of an antimicrobial guideline along with antibiotic stewardship program in every hospital could be helpful for prescribers to play role in containment of antimicrobial resistance.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 70-74
Premature Rupture of the Membrane– Microbiological Assessment
Authors: Naz Mah Zabin , Salam Soheli , Alam Md Shafiqul
Published: October 2024

Introduction: Premature rupture of membranes (PROM) refers to the breaking of the amniotic sac before the onset of labor. When this happens before 37 weeks of gestation, it is termed preterm (PROM). One critical aspect of managing PROM or PPROM is the microbiological assessment, as infection plays a significant role in the outcome for both mother and fetus. Methods: A prospective cross-sectional study was carried out in a private clinic at Dhaka from January 2023 to December 2023. A total of 50 pregnant patients (N=50) with PROM were enrolled in this study following the inclusive criteria. Data were collected in the predesigned data collection sheet. Data were analyzed statistical package for social science (SPSS). Result: Commonest organism 72% were no growth, 10% were streptococcus, 6% were candida, 2% were delivered alpha-hemolytic streptococcus, 2% were E. coli Conclusion: Premature rupture of membrane and chorioamnionitis may cause antagonistic maternal consequences linked to infection. Premature rupture of membrane indicated lower birth weight for infants. Proper antibiotics must be certain prophylactically for the anticipation of intra-partum infection in case of PROM.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 75-79
Principle-oriented versus Information-oriented Approach Towards Neuroanatomy: A Selective Profile of Question Papers of Four Public University of Bangladesh
Authors: Yeasmin Farida , Alam Md Shah , Jafrin Jerin , Hossain Shahana , Sultana Razia , Shamim Khondker Manzare
Published: October 2024

Most of the students considered neuroanatomy to be a difficult subject that contains a large volume of information. Therefore, many of them have the tendency to memorise the subject rather than understanding. The learning will be permanent if learning and its assessment is structured around generalisable rules or ‘principle’ rather than trying to memorise plenty of apparently disconnected ‘information’. Materials and methods: The Neuroanatomy portion of the Anatomy question papers of the First Professional MBBS Examinations of four public universities were analysed. It was a cross sectional, observational study carried out in the Department of Anatomy, Bangabandhu Sheikh Mujib Medical University, Dhaka from January 2012 to December 2012. Results: The analyses of written question papers revealed that a vast majority (85.40 ± 7.32%) of the question segments in the question papers of four public universities were ‘Information-based segments’. The mean proportion (±SD) of ‘principle-based segments’ was 14.60 ± 7.32%. Conclusion: The results of present study provide a baseline data on the relative proportion of ‘principle-based questions’ and ‘information-based questions’ in the Neuroanatomy portion of Anatomy question papers of four public universities in Bangladesh. The study also suggests that the issue of principle-oriented approach in the teach-learning and assessment of neuroanatomy is a valid issue to be addressed in the undergraduate curriculum planning and implementation.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 88-93
Study on Factors Associated with Poor Seizure Control in Epileptic Patients during Pregnancy
Authors: Al Mamun Kazi Abdullah , Salam Soheli , Hasan A K M Tariqul , Rashid Md Humayun
Published: October 2024

The management of epilepsy during pregnancy is always challenging. This study aims to analyze the factors associated with poor seizure control during pregnancy and to describe the most commonly used antiseizure drugs in these patients. We conducted a casecontrol study of pregnant patients with epilepsy between 2017 and 2022. 50 pregnant women with poorly controlled epilepsy were taken as cases and 50 pregnant women with well-controlled epilepsy were taken as controls. Patients were evaluated in the first and second trimesters of pregnancy and after delivery. Patients’ mean age was 32.6 years. 53% had focal epilepsy, 40% had generalized epilepsy and 5 % had undetermined epilepsy. The factors associated with poor control of seizure during pregnancy were duration of epilepsy, poor seizure control in the year prior to pregnancy, treatment with 2 or more antiseizure drugs, untreated epilepsy, missed medication dosages, decline in plasma concentrations of antiepileptic drug, presence of focal activity in EEG and abnormal imaging findings. Anti-seizure medications most widely used in monotherapy were lamotrigine, levetiracetam, carbamazepine, and valproate.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 99-103
Primary Squamous Cell Carcinoma of the Thyroid Gland Treated with Surgery and Concurrent Chemoradiotherapy, A Case Report
Authors: Jahan Israt , Ali Md Yousuf , Mostafa Md Niaz , Tarannum Tabia
Published: October 2024

Introduction: Primary squamous cell carcinoma (PSCC) of the thyroid gland is one of the rarest types of all reported thyroid malignancies worldwide. It is very aggressive in nature and carries a poor prognosis. The surgical resection with adjuvant radiotherapy and chemotherapy is the most recommended treatment despite its poor reported outcome. Case presentation: A 56-year-old Asian man presented with non-tender swelling of the neck, Patient underwent total thyroidectomy and histopathology revealed carcinoma thyroid, squamous cell carcinoma, and all other primary squamous cell carcinoma were excluded by imaging and immunohistochemistry. The patient completed radiotherapy concurrent with chemotherapy but after one year of completion of treatment died due to local recurrence. Conclusion: PSCC of the thyroid gland is difficult to diagnose and is a great challenge for the managing team to plan for the best treatment option, due to its unfavorable rate of survival and lack of consensus management guidelines.
EWMCJ Vol. 12, No. 1&2, January-July 2024: 107-110
Frequency, Causes and Medico-Legal Aspects of Grievous Injury to the Eye after Physical Assault
Authors: Shahid Erum , Fasih Uzma
Published: October 2024

Aims: A medicolegal report is prepared by the medicolegal officer in conjunction with an ophthalmologist in cases of physical assault claiming vision loss. The objective was to report the frequency and cause of grievous injury to the eye after a physical assault.
Methods: This was a descriptive cross-sectional study, conducted in the Department of Ophthalmology of a tertiary care hospital in Pakistan from October 2019 to August 2022. A total of 378 medicolegal cases were reported in the ophthalmology outpatient. Among them, 285 patients of physical assault were included with consecutive sampling technique.
Results: The mean age of the patients was 33.93±12.96 years. The mean reporting time to an ophthalmologist was 4.1±8.2 days. Simple and grievous injuries were found in 278 (97.5%) and 7 (2.4%) cases, respectively. Among the grievous injuries, 4 (57.2%) were close globe injuries and 3 (42.8%) were open globe injuries.   Thirteen (4.5%) were malingers. Domestic violence was observed in 82 (28.8%) study subjects.
Conclusion: The frequency of grievous injury to the eye is very low (2.4%) in patients with physical assault. The patients of assault-related grievous injury were mostly males, young age, low level of education, and doing manual jobs. Vitrolage with corneal melting, and firearm injury caused the grievous injury in open globe patterns. Vitreous hemorrhage, retinal detachment, macular hole, and secondary glaucoma were seen among close globe patterns.
J Bangladesh Coll Phys Surg 2024; 42: 336-341
Evaluation of Split Hand Syndrome in Early Diagnosis of Amyotrophic Lateral Sclerosis by Nerve Conduction Study as a Diagnostic Tool
Authors: Wazib Amit , Rahman Shaila , Ahmed Md Rayhan
Published: October 2024

Background: Amyotrophic lateral sclerosis (ALS), a degenerative disease of the motor neurons that can present diversly. Needle electromyography (EMG) is the gold standard investigation for the diagnosis of ALS. Split hand syndrome (SHS) demonstrated by nerve conduction study (NCS); a noninvasive tool could be useful in diagnosing ALS. This study aimed to assess SHS by NCS in ALS.
Methods: This diagnostic accuracy case-control study included 37 cases of ALS and 37 age and gender-matched controls. Compound muscle action potential (CMAP) and distal motor latency (DML) of median and ulnar nerves and the ratio of median and ulnar CMAP and DML were compared between study groups. The diagnostic validity testing of electrophysiological SHS was also done.
Results: The mean age of the ALS and control groups were similar, 39.8±2.7 and 39.3±2.6  years, respectively. Sixteen (43.2%) ALS patients were in 30-59 years age group. Male-female ratio was 5.2. In the ALS group, median-ulnar CMAP ratio was lower and median-ulnar DML ratio was prolonged than the control. The diagnostic efficacy of median-ulnar CMAP ratio and DML ratio were calculated. A median-ulnar CMAP ratio cut-off value ≤1 showed 70% sensitivity, 97% specificity, 96% positive predictive value and 77% negative predictive value. A median-ulnar DML ratio cut-off value ≥1.5 showed 48% sensitivity, 89% specificity, 82% positive predictive value and 65% negative predictive value.
Conclusion: NCS demonstrating SHS can be an important tool in the early diagnosis of ALS.
J Bangladesh Coll Phys Surg 2024; 42: 350-354
Inadvertent Disclosure of HIV Status to Adolescents Living with HIV and Subsequent Impact on Medico-Social Wellbeing in Kaduna, Nigeria
Authors: Shuaibu Musa
Published: October 2024

Background: Inadvertent disclosure of HIV status poses significant challenges for adolescents living with HIV, particularly in settings where stigma and discrimination are prevalent. Objective: This research seeks to delve into the prevalence and ramifications of accidental disclosures of HIV status among adolescents frequenting a Youth Friendly Clinic (YFC) at a major hospital in Kaduna, Nigeria. It further aims to uncover the medical and social repercussions following such incidents. Methods: Employing a comprehensive mixed-methods strategy, this study combined quantitative and qualitative analyses. Initially, a survey was conducted among 217 adolescents aged between 10 and 19 years, who were patients at the YFC of a tertiary care facility. This survey gathered information on demographic factors, experiences related to the disclosure of HIV status, and the effects of accidental disclosures on emotional health and the consistency of antiretroviral treatment adherence. Subsequently, the study engaged in qualitative research through detailed interviews and group discussions with 85 adolescents who had unintentionally disclosed their HIV status. This allowed for an exploration of the experiences surrounding these disclosures, the coping strategies adopted, and their perceptions of available support. Ethical clearance was secured to ensure the confidentiality and integrity of the research process. Results: The initial analysis revealed that a significant portion (39.2%) of the adolescent participants had inadvertently disclosed their HIV status, mostly by overhearing conversations (56%) and through discussions with peers at the clinic (17%). The qualitative exploration identified key themes such as heightened experiences of stigma and discrimination, difficulties in securing social support, and detrimental effects on mental health. Following these unintended disclosures, adolescents reported feelings of social isolation, changed perceptions by family members, and battles with depression and anxiety. The findings highlight the intricate relationship between accidental disclosure and its social and medical impacts, emphasizing the necessity for bespoke interventions aimed at addressing the needs of this at-risk demographic. Conclusion: The confidentiality of adolescent patients must be a top priority for healthcare professionals, alongside the development of preventative measures against accidental disclosures and the provision of comprehensive support services to counteract the adverse outcomes. By enhancing privacy protection and offering individualized support, it is feasible to mitigate the negative effects associated with unintended disclosures, including stigma and mental health challenges. This investigation enriches our comprehension of accidental HIV status disclosure among adolescents and accentuates the critical need for creating interventions that improve their overall well- being and social inclusion.
Upaya meningkatkan hasil belajar bulutangkis materi pukulan forehand lob melalui metode teaching games for understanding pada siswa kelas V C di sekolah dasar negeri pulogebang 01 jakarta timur
Authors: Supriadi Wahyu , Abidin Dindin
Published: October 2024

Tujuan penelitian ini untuk mengetahui apakah pendekatan teaching games for understanding dapat meningkatkan hasil belajar pukulan forehand lob permainan bulutangkis pada siswa kelas V.C Sekolah Dasar Negeri Pulogebang 01 Jakarta Timur. Adapun metode yang digunakan dalam penelitian ini adalah penelitian tindakan kelas (classroom action research), sedangkan subyek dalam penelitian ini adalah, siswa kelas kelas V.C Sekolah Dasar Negeri Pulogebang 01 Jakarta Timur yang berjumlah. 32 orang.
Hasil penelitian telihat peningkatan hasil belajar pukulan forehand lob permainan bulutangkis, obervasi awal menunjukkan hanya 15 orang (46.88%) siswa yang mencapai nilai KKM. Pada siklus 1 terdapat peningkatan yang cukup signifikan hasil menunjukkan 21 orang siswa (65.63%) siswa yang mencapai nilai KKM. Sedangkan pada siklus 2 didapat hasil 26 orang siswa (81.25%) siswa yang mencapai nilai KKM Pada siklus 2 hasil yang dicapai  telah sesuai dengan apa yang di targetnya yaitu 75% siswa telah mencapai nilai KKM, dalam hal ini 81.25% siswa telah mencapai nilai KKM, sehingga tidak dilanjutkan pada siklus III.
Enhancing Human Capital Management through DevOps Practices
Authors: Suharminto Bayu Dwi , Wijaya Alek , Sutabri Tata , Syazili Ahmad
Published: October 2024

In the current era of digital revolution, one of the main factors influencing an organization's performance is human resources. This is because HR is an important asset that determines the productivity and efficiency of organizational performance. This study's goal is to create and construct an integrated human resources application using the DevOps (Development and Operations) approach. The DevOps method is a collabo         rative approach that combines the process of software development and operations in a sustainable, fast, and integrated manner. The human resources application developed in this research includes various important functions, including HR management, job grade promotion planning, employment contract termination notification, and promotion notification. This research also provides solutions to the problems experienced by the Palembang Region Office of PT Bank Rakyat Indonesia in human resource management. By using the DevOps method as a method of designing human capital applications, it is expected to increase employee efficiency and productivity through integrated and effective human resource management. The DevOps approach also allows organizations to respond quickly to changing needs and provide sustainable added value to the organization.
Eligibility Recipients Determination of El-Nino Direct Cash Aid Using C4.5 Algorithm
Authors: Putri Dini Elldrica , Efendi Dwi Marisa , Aminah Siti
Published: October 2024

The El Nino phenomenon, which causes increased temperatures and prolonged drought, is predicted to continue to hit Indonesia until the end of 2023. The significant impacts of El Nino include reducing the productivity of agricultural products, including food crops such as rice. This condition will certainly greatly affect the stability of domestic food prices. A total of 420 people from Bernah Village, Kota Alam Subdistrict received it. In the selection process for BLT El Nino recipients in Bernah Village, problems often occur such as problems in identifying aid recipients. This creates a society where aid recipients are still relatively well-off. By applying the C4.5 Algorithm, the C4.5 Calculation can determine feasibility thereby increasing efficiency in determining El Nino Direct Cash Assistance receipts. Calculations using Microsoft Excel 2010 revealed that there were 252 eligible recipients while 168 were not eligible. And from the calculation results using Rapid Miner 10.1. It is known that the accuracy rate is 100.00% with a total of 420 people receiving aid data.
A Comparative Analysis of MultinomialNB, SVM, and BERT on Garuda Indonesia Twitter Sentiment
Authors: Prasetyo Budi , Ahmad Yusuf Al-Majid  , Suharjito
Published: October 2024

This study investigates customer sentiment towards Garuda Indonesia Airlines (GIA) using sentiment analysis of Twitter data. The research aims to identify prevailing sentiments, uncover common themes in customer feedback, and provide recommendations for improving customer satisfaction and brand loyalty. A dataset of 1,250 tweets from March 2007 to July 2024 was collected and pre-processed, including cleaning, language detection, and tokenization. Sentiment analysis was conducted using three models: MultinomialNB, SVM, and BERT.The results indicate that BERT outperformed both MultinomialNB and SVM in sentiment classification accuracy, achieving 75.6%. This highlights the effectiveness of BERT in capturing contextual meaning within customer reviews. The findings of this research will contribute to a deeper understanding of customer sentiment towards GIA and inform strategies for enhancing customer experience and brand image.
Navigating a Rare Presentation: Case Report of a Large Gartner’s Duct Cyst
Authors: Kumari Rajesh , Aggarwal Ashita , Nisha  , Deoghare Manasi , Khan Muntaha , Manchanda Smita , Sharma Jai Bhagwan
Published: October 2024

Background: Mullerian ducts form the female genital tract and wolffian ducts form the male genital tract. In females, sometimes the wolffian duct persists and form the Gartner duct and its total or partial occlusion results in the formation of Gartner’s cyst. It is typically small and asymptomatic and occurs along the antero-lateral wall of vagina.

Methods and Results: We report a case of 40-year-old woman who presented with a big mass coming out per vaginum. After examination, she was provisionally diagnosed as Gartner duct cyst, excision was done and confirmed as a case of Gartner’s duct cyst on histopathological examination.

Conclusion: A good clinical examination along with radiological investigations aids in making a timely diagnosis and surgical management.
Use of Fuzzy Logic in Determining the Academic Achievement of Secondary School Students in Mathematics Class
Authors: Türkmen Muhammed Recai , Killik Ecenaz
Published: October 2024

Many studies have been found in the field of education using the fuzzy logic approach. However, no study has been found examining the academic achievement of secondary school students in mathematics. The research data consists of the exam notes of the 1st term 1st and 2nd Mathematics course of the 2023-2024 academic year in Kütahya. The study consists of the exam scores of 876 students studying in 4 secondary schools in the center of Kütahya. To study a fuzzy logic-based two-input and single-output system was designed using Fuzzy Logic Toolbox in the Matlab program. Totally 9 fuzzy rules were created. The academic success was evaluated first with classical method and then with the designed fuzzy-based model. According to the results obtained, it has been observed that there is a high positive relationship between fuzzy logic method and classical logic method. It was academic success score obtained fuzzy logic method was less than classical logic method for grades 5 and 7. But it was obtained fuzzy logic method was more than classical logic method for grades 6 and 8. In conclusion was reached in favor of fuzzy logic due to fuzzy logic method gives more flexible results.
Automatic recognition of coffee bean varieties based on pre-trained architectures
Authors: Yonar Aynur , Özaltın Öznur
Published: October 2024

Coffee is an agricultural commodity of fundamental and considerable economic importance on the global market. In this study, the coffee bean varieties were examined from images via artificial intelligence due to their quality and value on the market. This study aims to create an automated system that can efficiently identify coffee beans without requiring a significant amount of time. In this study, five pre-trained Convolutional Neural Network (CNN) architectures were performed to detect four varieties of coffee beans through images. Extracting features from images is a challenging and specialized task. However, CNN possesses the ability to extract features automatically. Therefore, these architectures were employed as both deep feature extractors and classifiers. Primarily, 1600 coffee beans' images were split into 75:25 training and testing sets. Next, 5-fold cross-validation was applied during the training process. This study presented both validation and testing results. Eventually, ShuffleNet achieved the best classification performance with 99.33% and 99.75% accuracy rates in identifying types of coffee beans for the training and testing sets, respectively. As a result, this study has demonstrated that deep learning technologies can automatically recognize the different types of coffee beans.
Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells
Authors: Bauer Niels , Boettger Marco , Papadaki Styliani , Leitner Tanja , Klostermann Stefan , Kettenberger Hubert , Georges Guy , Larraillet Vincent , Gluhacevic von Kruechten Dino , Hillringhaus Lars , Vogt Annette , Ausländer Simon , Popp Oliver
Published: October 2024

We present a detailed mass spectrometric analysis of three 2 + 1 T-cell bispecific monoclonal antibodies (TCB mAbs), where an unexpected +15.9950 Da mass shift in tryptic peptides was observed. This modification was attributed to the occurrence of 5R-hydroxylysine (Hyl) using a hybrid LC–MS/MS molecular characterization and CRISPR/Cas9 gene deletion approach. The modification was found at various sites within TCB mAbs, with a conspicuous hot spot motif mirroring a prior observation where Hyl was mapped to the CH1–VH Fab domain interface of IgGs. In contrast to the preceding report, our structural modeling analysis on TCB mAbs unveiled substantial differences in the orientation and flexibility of motifs in immediate proximity and across the artificial CH1–VL cross Fab interface and upstream elbow segment. Utilizing a hybrid database search, RNAseq, and a CRISPR/Cas9 knockout methodology in Chinese hamster ovary (CHO) production cell lines, procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) were conclusively identified as the catalyzing enzymes accountable for the 5R-Hyl modification in TCB mAbs. To quantitatively inhibit Hyl formation in TCB mAbs, the activity of all three Chinese hamster PLOD isoenzymes needs to be depleted via CRISPR/Cas9 gene knockout. Moreover, our investigation identified cell culture iron availability, process duration, and clonal variability in CHO cells as elements influencing the levels of Hyl formation in TCB mAbs. This research offers a solution for circumventing Hyl formation in therapeutic complex mAb formats, such as TCB mAbs, produced in CHO cell culture processes, thereby addressing potential technical and biological challenges associated with unintended Hyl modification.
Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection
Authors: Ali Nouran Abdelmageed , Morsi Nadia M. , Badr-Eldin Shaimaa M. , Shamma Rehab N.
Published: October 2024

Introduction

Osteoarthritis (OA) is regarded as one of the most prevealent irreversible joint degenerative disorder worldwide. Recently, considerable interest in utilizing intra-articular (IA) injections for managing OA has been raised.

Methods

In this study, IA injectable surface modified iron oxide microparticles (SMIOMPs) loaded with Diacerein (DCN) were developed. The effects of formulation parameters on particle size, entrapment efficiency, and zeta potential were explored using factorial design. The optimized formulation was characterized regarding morphology and in vitro release. Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) were done to assess interactions. Further, sterilization and in vivo performance in rats with induced arthritis has been performed for the optimized formulation.

Results and Discussion

The selected optimized system included 2M FeCL3 and 1% chitosan as a surface modifier achieved high drug entrapment of 85.25% with a PS of 1.54 µm and sustained DCN release. Morphological examination of the optimized formulation revealed spherical particles with chitosan coat. DSC and FTIR results indicated the absence of undesired interactions between DCN and the used components. No significant change in the measured parameters was observed following sterilization using gamma radiation. In vivo assessment revealed superior performance for the optimized formulation in reducing cartilage inflammation and degradation. Plasma levels of tumor necrosis factor α and Interleukin-1 beta, as well as knee diameter, were significantly reduced in the treated groups compared to the untreated ones.

Conclusion

Overall, the results suggest that the proposed DCN-loaded SMIOMPs represent a promising advancement in the arena of cartilage regeneration.
Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys
Authors: Schweitzer Luiz , Schoon Janosch , Bläß Niklas , Huesker Katrin , Neufend Janine V. , Siemens Nikolai , Bekeschus Sander , Schlüter Rabea , Schneider Peter , Uhlmann Eckart , Wassilew Georgi , Schulze Frank
Published: October 2024

Background/Objective

Endoprostheses might fail due to complications such as implant loosening or periprosthetic infections. The surface topography of implant materials is known to influence osseointegration and attachment of pathogenic bacteria. Laser-Induced Periodic Surface Structures (LIPSS) can improve the surface topography of orthopedic implant materials. In this preclinical in vitro study, laser pulses with a wavelength in the ultraviolet (UV) spectrum were applied for the generation of LIPSS to positively influence formation of extracellular matrix by primary human Osteoblasts (hOBs) and to reduce microbial biofilm formation in vitro.

Methods

Laser machining was employed for generating UV-LIPSS on sample disks made of Ti6Al4V and Ti6Al7Nb alloys. Sample disks with polished surfaces were used as controls. Scanning electron microscopy was used for visualization of surface topography and adherent cells. Metal ion release and cellular metal levels were investigated by inductively coupled plasma mass spectrometry. Cell culture of hOBs on sample disks with and without UV-LIPSS surface treatments was performed. Cells were investigated for their viability, proliferation, osteogenic function and cytokine release. Biofilm formation was facilitated by seeding Staphylococcus aureus on sample disks and quantified by wheat germ agglutinin (WGA) staining.

Results

UV-LIPSS modification results in topographies with a periodicity of 223 nm ≤ λ ≤ 278 nm. The release of metal ions was found increased for UV-LIPSS on Ti6Al4V and decreased for UV-LIPSS on Ti6Al7Nb, while cellular metal levels remain unaffected. Cellular adherence was decreased for hOBs on UV-LIPSS Ti6Al4V when compared to controls while proliferation rate was unaffected. Metabolic activity was lower on UV-LIPSS Ti6Al7Nb when compared to the control. Alkaline phosphatase activity was upregulated for hOBs grown on UV-LIPSS on both alloys. Less pro-inflammatory cytokines were released for cells grown on UV-LIPSS Ti6Al7Nb when compared to polished surfaces. WGA signals were significantly lower on UV-LIPSS Ti6Al7Nb indicating reduced formation of a S. aureus biofilm.

Conclusion

Our results suggest that UV-LIPSS texturing of Ti6Al7Nb positively influence bone forming function and cytokine secretion profile of hOBs in vitro. In addition, our results indicate diminished biofilm formation on UV-LIPSS treated Ti6Al7Nb surfaces. These effects might prove beneficial in the context of long-term arthroplasty outcomes.
Genetic and metabolic engineering approaches for enhanced biodesulfurization of petroleum fractions
Authors: Bagchi Asheemita , Srivastava Preeti
Published: October 2024

Sulfur, an abundant component of crude oil, causes severe damage to the environment, poses risks to human health, and poisons the catalysts used in combustion engines. Hydrodesulfurization, the conventionally used method, is not sufficient to remove thiophenes like dibenzothiophene (DBT) and other aromatic heterocyclic compounds. The push for “ultra-clean” fuels, with sulfur content less than 15 ppm, drives the need for deep desulfurization. Thus, in conjunction with hydrodesulfurization, efficient and eco-friendly methods of deep desulfurization, like biodesulfurization, are desirable. In biodesulfurization, naturally desulfurizing microorganisms are used, with genetic engineering and biotechnology, to reduce the sulfur content of crude oil to below 15 ppm. In this review, we describe genetic and metabolic engineering approaches reported to date to develop more efficient methods to carry out biodesulfurization, making it a practically applicable reality.