bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of a motor control exercise program on lumbopelvic pain recurrences and intensity in pregnant women with a history of lumbopelvic pain: a study protocol for a randomized controlled feasibility trial
Authors: Daneau Catherine , Marchand Andrée-Anne , Bussières André , O’Shaughnessy Julie , Ruchat Stephanie-May , Descarreaux Martin
Published: March 2022

Background

About 50% of women experience lumbopelvic pain (LBPP) during their pregnancy. LBPP has negative repercussions on sleep, social and sexual life, physical and work capacity, and psychological health and contributes to physical inactivity. The benefits of LBPP prevention or treatment in pregnant women through specific exercises should therefore be further investigated. This study protocol has been designed to establish the feasibility of implementing motor control exercise program with pregnant women presenting with a history of LBPP.

Methods/design

Forty pregnant women with a history of LBPP will be recruited and randomly allocated to a control (20 participants) or intervention (20 participants) group. The control group will receive standard prenatal care, including basic information on what to do when suffering from LBPP. The intervention group will participate in three 40-min exercise sessions per week from < 20 weeks until 34–36 weeks of gestation: one supervised group session via the Zoom platform (once a month, this session will take place at the Université du Québec à Trois-Rivières) and two unsupervised sessions at home. A motor control exercise program will be developed to target strengthening of the lumbo-pelvic-hip core muscles and improve spinal and pelvic stabilization. Participants of this group will also receive standard prenatal care. Women of the control group will receive after 6 weeks postpartum an exercise program designed to reduce LBPP they may have developed during pregnancy and that may persist after delivery. Primary outcomes will be participants’ recruitment, retention and adherence rates, safety, and acceptability of the intervention. Secondary outcomes will include LBPP incidence, frequency, and intensity, as well as self-reported functional disability, physical activity levels, fear avoidance behavior, anxiety, and depression.

Discussion

This study will inform the feasibility of conducting a full-scale randomized controlled study to test the effectiveness of a motor control exercise program on the prevention and treatment of LBPP in women with a history of LBPP. Adequate prevention and treatment of pregnant women with a history of LBPP should help limit the recurrences of LBPP or the aggravation of its intensity during pregnancy.

Trial registration

US National Institutes of Health Clinical Trials registry NCT04253717 April 27, 2021.
Enhanced osseointegration of dental implants with reduced graphene oxide coating
Authors: Shin Yong Cheol , Bae Ji-Hyeon , Lee Jong Ho , Raja Iruthayapandi Selestin , Kang Moon Sung , Kim Bongju , Hong Suck Won , Huh Jung-Bo , Han Dong-Wook
Published: March 2022

Background

The implants of pure titanium (Ti) and its alloys can lead to implant failure because of their poor interaction with bone-associated cells during bone regeneration. Surface modification over implants has achieved successful implants for enhanced osseointegration. Herein, we report a robust strategy to implement bioactive surface modification for implant interface enabled by the combinatorial system of reduced graphene oxide (rGO)-coated sandblasted, large-grit, and acid-etched (SLA) Ti to impart benefits to the implant.

Methods

We prepared SLA Ti (ST) implants with different surface modifications [i.e., rGO and recombinant human bone morphogenetic protein-2 (rhBMP-2)] and investigated their dental tissue regenerating ability in animal models. We performed comparative studies in surface property, in vitro cellular behaviors, and in vivo osseointegration activity among different groups, including ST (control), rhBMP-2-immobilized ST (BI-ST), rhBMP-2-treated ST (BT-ST), and rGO-coated ST (R-ST).

Results

Spectroscopic, diffractometric, and microscopic analyses confirmed that rGO was coated well around the surfaces of Ti discs (for cell study) and implant fixtures (for animal study). Furthermore, in vitro and in vivo studies revealed that the R-ST group showed significantly better effects in cell attachment and proliferation, alkaline phosphatase activity, matrix mineralization, expression of osteogenesis-related genes and protein, and osseointegration than the control (ST), BI-ST, and BT-ST groups.

Conclusion

Hence, we suggest that the rGO-coated Ti can be a promising candidate for the application to dental or even orthopedic implants due to its ability to accelerate the healing rate with the high potential of osseointegration.
The degradation of poloxamer 188 in buffered formulation conditions
Authors: Chen Wei , Stolz Siegfried , Wegbecher Vincent , Parakkattel Dixy , Haeuser Christina , Oltra Nuria Sancho , Kishore Ravuri S. K. , Bond Steven , Bell Christian , Kopf Robert
Published: March 2022

Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intactness is crucial to the stability of drug products due to its protecting effects at interfaces. In order to identify and mitigate potential risks that might cause the degradation of P188 during the manufacturing process and storage, in the current work, the stability of P188 was investigated by forced degradation in buffered formulation conditions via oxidation and thermal stress conditions. The process of degradation was monitored through the dedicated liquid adsorption chromatography (LAC) with high sensitivity, and the degradants were characterized by high-resolution mass spectrometry. Results suggest that the vulnerability of P188 is largely related to the buffer conditions. Histidine promotes degradation in the presence of hydroxyl radicals but inhibits the degradation in the presence of H2O2 and alkyl radicals. In thermal stress conditions, histidine protects P188 from degradation at 40 °C, and activates its decay only at higher temperature, like 60 °C.
Recent trends of microbial decontamination for occupational, industrial and domestic applications
Authors: Elkhatat Ahmed M.
Published: March 2022

Background

Nowadays, engineers face challenges in developing novel technologies to find environmental and industrial solutions to address microbial contamination Microbes and treated objects differ significantly in their ability to tolerate the decontamination methods.

Main text

This work introduces a comprehensive review of recent trends of microbial decontamination for occupational, industrial, and domestic applications to help design and optimize suitable decontamination approaches.

Conclusions

Decontamination methods vary in their effectiveness towards microorganisms as sanitizing is the least effective decontamination method; disinfectants and antiseptics provide a higher level of decontamination. However, the best decontamination method is sterilizing. Hence, Microbial decontamination methods must be designed according to the level of microbes resistivity and the sensibility of the treated material.

Graphical abstract
Diagnosing SARS-CoV-2 vaccination associated rhombencephalitis requires comprehensive work-up and exclusion of differentials
Authors: Finsterer Josef , Scorza Fulvio A. , Scorza Carla A. , Fiorini Ana C.
Published: March 2022

In this letter we raise several concerns regarding the interesting article by Walter and Krämer about rhomb-encephalitis as a complication two months after the vaccination with an mRNA-based SARS-CoV_2 vaccine. The causal link between the vaccination and encephalitis remained unproven, a SARS-CoV-2 infection, Bickerstaff encephalitis were not excluded, the MRI rather suggests brainstem-encephlaitis than pure rhomb-encephalitis, and the cerebro-spinal fluid was not investigated for cytokines or glial markers. Neurologists are called to make all available effort to convincingly evaluate the etiology and the pathophysiological background of an undetermined condition.
A rare case of unilateral tonsillar epidermoid cyst
Authors: Singhal Gaurang , Kumar Pallika , Pathak Anjali , Rani Poonam
Published: March 2022

Background

Epidermoid cyst is a developmental lesion with 1.6–6.9% cases found in the head and neck region. Intraoral epidermoid cyst is a rare finding and intratonsillar epidermoid cyst is even rarer, with less than 0.01% incidence.

Case presentation

We are reporting a case of 16 year old with complain of unilateral tonsillar enlargement since 5 months. She underwent tonsillectomy under general anesthesia, and the specimen was sent for histopathological examination. It was reported as multiple intratonsillar epidermoid cysts on final histopathological examination.

Conclusion

We would like to report such a case due to its rarity and to recommend the need for histopathological diagnosis after every case of tonsillectomy in order to differentiate various benign and malignant lesions for their proper management.
Transient otoacoustic emissions with contralateral suppression findings in COVID-19 patients
Authors: Basoz Meliha , Tas Nida , Gedik Ozge , Ozdemir Sumeyye , Aksoy Fadlullah
Published: March 2022

Objective

The virus called SARS-CoV-2, which is known as the first epidemic of the twenty-first century, is known to affect the central and peripheral nervous system. In the literature, complaints of sudden hearing loss, tinnitus, and vertigo have been reported in the patients.

The aim of this study is to objectively reveal the effect of the coronavirus disease 2019 on the efferent auditory system.

Methods

Twenty-three participants, who had the coronavirus disease 2019, were included in the study group, while 20 healthy participants were included in the control group. The test of transient otoacoustic emissions with contralateral suppression was applied to individuals who had normal audiological and immitansmetric evaluations findings.

Results

In audiological evaluation, a significant difference was observed between the groups in the 125–500 Hz low frequency range and 4 kHz–12.5 kHz high frequency range. In the test of TEOAE and TEOAE with contralateral suppression, a significant difference was observed between the groups at 4 kHz.

Conclusion

The effect of the coronavirus disease 2019 on the peripheral hearing system has been shown. Its effect on the efferent hearing system in the high frequency region has been revealed.
Multiparametric MRI radiomics nomogram for predicting lymph-vascular space invasion in early-stage cervical cancer
Authors: Xiao Meiling , Li Ying , Ma Fenghua , Zhang Guofu , Qiang Jin
Published: March 2022

Objective:

To develop a radiomics nomogram based on multiparametric MRI (mpMRI) to pre-operatively predict lymph-vascular space invasion (LVSI) in patients with early-stage cervical cancer.

Methods:

This retrospective study included 233 consecutive patients with Stage IB–IIB cervical cancer. According to the ratio of 2:1, 154 patients and 79 patients were randomly assigned to the primary and validation cohorts, respectively. Features with intraclass and interclass correlation coefficient (ICCs) greater than 0.75 were selected for radiomics features. The significant features for predicting LVSI were selected using the least absolute shrinkage and selection operator (LASSO) algorithm based on the primary cohort. The rad-score for each patient was constructed via a linear combination of selected features that were weighted by their respective coefﬁcients. The radiomics nomogram was developed using multivariable logistic regression analysis by incorporating the rad-score and clinical risk factors.

Results:

A total of 19 radiomics features and 3 clinical risk factors were selected. The rad-score exhibited a good performance in discriminating LVSI with a C-index of 0.76 and 0.81 in the primary and validation cohorts, respectively. The radiomics nomogram also exhibited a good discriminating performance in two cohorts (C-index of 0.78 and 0.82). The calibration curve of the radiomics nomogram demonstrated no significant differences was found between prediction and observation outcomes for the probability of LVSI in two cohorts (p = 0.86 and 0.98, respectively). The decision curve analysis indicated that clinician and patients could benefit from the use of radiomics nomogram and rad-score.

Conclusion:

The nomogram and rad-score could be used conveniently and individually to predict LVSI in patients with early-stage cervical cancer and facilitate the treatment decision for clinician and patients.

Advances in knowledge:

The nomogram could pre-operatively predict LVSI in early-stage cervical cancer.
Κρατικές ενισχύσεις προς τις τράπεζες στο πλαίσιο της χρηματοπιστωτικής κρίσης
Authors: Παπά Κυριακή
Published: March 2022

Αντικείμενο της παρούσας διδακτορική διατριβής είναι οι κρατικές ενισχύσεις προς τις τράπεζες στο πλαίσιο της χρηματοπιστωτικής κρίσης. Στο πλαίσιο αυτό εξετάζονται τα δύο βασικά ζητούμενα της χορήγησης κρατικών ενισχύσεων στις τράπεζες : η διασφάλιση σταθερότητας του χρηματοπιστωτικού συστήματος και η προάσπιση του ελεύθερου ανταγωνισμού. Η διατριβή επικεντρώνεται στο κομμάτι του δεύτερου ζητούμενου της χορήγησης κρατικών ενισχύσεων στις τράπεζες, την προάσπιση του ελεύθερου ανταγωνισμού. Εξετάζονται ειδικότερα τα αντισταθμιστικά μέτρα που ελήφθησαν από τις τράπεζες δικαιούχους κρατικής ενίσχυσης για την επίτευξη του ζητουμένου αυτού. Πρόκειται για μέτρα που έλαβαν οι τράπεζες αυτές προκειμένου να αντισταθμιστεί το όφελος που έλαβαν από την κρατική ενίσχυση και να προστατευτεί ο ελεύθερος ανταγωνισμός, όπως εκποιήσεις, απαγόρευση εξαγορών καθώς και απαγόρευση κατοχής ηγετικών θέσεων στις τιμές. Στόχος της διδακτορικής διατριβής είναι να αξιολογηθεί εάν τα αντισταθμιστικά μέτρα διασφάλισαν, ως όφειλαν να κάνουν, την προστασία του ελεύθερου ανταγωνισμού, εξετάζεται με άλλα λόγια η αποτελεσματικότητα των εν λόγω μέτρων στο θέμα αυτό. Στο πλαίσιο αυτό ερευνάται εάν τα αντισταθμιστικά μέτρα προκάλεσαν περαιτέρω στρεβλώσεις του ανταγωνισμού, αντί να τις περιορίσουν, όπως έχουν ως στόχο και όπως αναμένεται από την εφαρμογή τους. Πέραν τούτου αξιολογείται η αποτελεσματικότητα των αντισταθμιστικών μέτρων - ως προς την προστασία του ελεύθερου ανταγωνισμού - και υπό το πρίσμα των αρχών της αναλογικότητας και της ίσης μεταχείρισης. Εξετάζεται, ειδικότερα, εάν είναι σύμφωνα με την αρχή της αναλογικότητας και της ίσης μεταχείρισης μέτρα που ενδέχεται να στρεβλώνουν τον ελεύθερο ανταγωνισμό.
Stigma-directed services (Stig2Health) to improve ‘linkage to care’ for people living with HIV in rural Tanzania: study protocol for a nested pre-post implementation study within the Kilombero and Ulanga Antiretroviral Cohort
Authors: Magnolini Raphael , Senkoro Elizabeth , Kalinjuma Aneth Vedastus , Kitau Olivia , Kivuma Bernard , Samson Leila , Eichenberger Anna , Mollel Getrud Joseph , Krinke Eileen , Okuma James , Ndege Robert , Glass Tracy , Mapesi Herry , Vanobberghen Fiona , Battegay Manuel , Weisser Maja
Published: March 2022

Background: HIV-related stigma is a major barrier to the timely linkage and retention of patients in HIV care in sub-Saharan Africa, where most people living with HIV/AIDS reside. In this implementation study we aim to evaluate the effect of stigma-directed services on linkage to care and other health outcomes in newly diagnosed HIV-positive patients.

Methods: In a nested project of the Kilombero and Ulanga Antiretroviral Cohort in rural Tanzania, we conduct a prospective observational pre-post study to assess the impact of a bundle of stigma-directed services for newly diagnosed HIV positive patients. Stigma-directed services, delivered by a lay person living with HIV, are i) post-test counseling, ii) post-test video-assisted teaching, iii) group support therapy and group health education, and iv) mobile health. Patients receiving stigma services (enrolled from 1st February 2020 to 31st August 2021) are compared to a historical control receiving the standard of care (enrolled from 1st July 2017 to 1st February 2019). The primary outcome is ‘linkage to care’. Secondary endpoints are retention in care, viral suppression, death and clinical failure at 6-12 months (up to 31st August 2022). Self-reported stigma and depression are assessed using the Berger Stigma scale and the PHQ-9 questionnaire, respectively. The sample size calculation was based on cohort data from 2018. Assuming a pre-intervention cohort of 511 newly diagnosed adults of whom 346 (68%) were in care and on antiretroviral treatment (ART) at 2 months, a 10% increase in linkage (from 70 to 80%), a two-sided type I error rate of 5%, and 90% power, 321 adults are required for the post-implementation group.

Discussion: We expect that integration of stigma-directed services leads to an increase of proportions of patients in care and on ART. The findings will provide guidance on how to integrate stigma-directed services into routine care in rural sub-Saharan Africa.
Integrating augmented reality technology in education: vector personal computer augmented reality
Authors: Tan Sin Yin , Tay Noel Nuo Wi
Published: March 2022

Background: Educators often face difficulties in explaining abstract concepts such as vectors. During the ongoing coronavirus disease 2019 (COVID-19) pandemic, fully online classes have also caused additional challenges to using conventional teaching methods. To explain a vector concept of more than 2 dimensions, visualization becomes a problem. Although Microsoft PowerPoint can integrate animation, the illustration is still in 2-dimensions. Augmented reality (AR) technology is recommended to aid educators and students in teaching-learning vectors, namely via a vector personal computer augmented reality system (VPCAR), to fulfil the demand for tools to support the learning and teaching of vectors.

Methods: A PC learning module for vectors was developed in a 3-dimensional coordinate system by using AR technology. Purposive sampling was applied to get feedback from educators and students in Malaysia through an online survey. The supportiveness of using VPCAR based on six items (attractiveness, easiness, visualization, conceptual understanding, inspiration and helpfulness) was recorded on 5-points Likert-type scales. Findings are presented descriptively and graphically.

Results: Surprisingly, both students and educators adapted to the new technology easily and provided significant positive feedback that showed a left-skewed and J-shaped distribution for each measurement item, respectively. The distributions were proven significantly different among the students and educators, where supportive level result of educators was higher than students. This study introduced a PC learning module other than mobile apps as students mostly use laptops to attend online class and educators also engage other IT tools in their teaching.

Conclusions: Based on these findings, VPCAR provides a good prospect in supporting educators and students during their online teaching-learning process. However, the findings may not be generalizable to all students and educators in Malaysia as purposive sampling was applied. Further studies may focus on government-funded schools using the newly developed VPCAR system, which is the novelty of this study.
Evaluation of the potential benefits of iron supplementation in organic pig farming
Authors: Prunier Armelle , Leblanc-Maridor Mily , Pauwels Maud , Jaillardon Laetitia , Belloc Catherine , Merlot Elodie
Published: March 2022

Background: Iron from the stock acquired during foetal life and the ingestion of milk is not sufficient to cover the needs of the piglets during their first weeks of life. In organic farming, systematic supplementation with iron is problematic due to a strong limitation in pharmaceutic treatments.

Methods: Erythroid parameters around weaning were measured in piglets from organic outdoor and indoor farms, and related to indicators of the inflammatory status. Blood samples were collected from 28.9±2.6 piglets/herd at 42.0±3.2 days of age and 11.9±3.0 kg live weight (mean ± SD) in 21 farms from the west part of France. Among the 11 outdoor farms, only one had supplemented piglets with 200 mg iron while among the 10 indoor farms, only one had not supplemented piglets, one had supplemented them with 100 mg, 8 with 200 mg and one with 400 mg.

Results: Compared to outdoor piglets without supplementation, piglets kept indoors and receiving 200 mg iron had lower haemoglobin concentration (105 vs 118±2 g/l, mean ± SE) and red blood cell volume (56 vs 60±1 fl) (P<0.005). The reduction in haemoglobin concentration and red blood cell volume was more pronounced in indoor piglets supplemented with 100 mg of iron and even more when they had not received iron. The plasma concentration of haptoglobin was lower in outdoor than in indoor piglets (0.51±0.06 vs 0.78±0.09 g/l) whereas no effect of housing was observed for markers of oxidative stress (dROM, BAP). In the 14 farms where sow parity was known, the haemoglobin concentration was lower in piglets from primiparous than from multiparous sows (109 versus 114±2 g/l, P < 0.001).

Conclusion: With the exception of soils where the content of bioavailable iron is very low, piglets from outdoor farms do not require iron supplementation, unlike those raised indoors.
INVESTIGATION OF THE FUNGICIDAL ACTIVITY OF NEW DERIVATIVES OF 7-R-1,5-DINITRO-3,7- DIAZABICYCLO[3.3.1]NONAN-2-ONE
Authors: Ivanova Evgeniya V. , Nikishina Maria B. , Tretyakova Anastasia V. , Mukhtorov Loik G. , Perelomov Leonid V. , Atroshchenko Yuri M.
Published: March 2022

ackground. The problem of finding new effective fungicides for agriculture remains an urgent task of modern agrochemistry. The problem is exacerbated by the fact that, on the one hand, over the years, there has been an ever wider spread of fungi-phytopathogens, due to the intensification of agricultural production, and, on the other hand, there is an increase in the resistance of pathogens of fungal diseases to the available fungicides. This study is devoted to the study of the fungicidal activity of new derivatives of 3,7-diazabicyclo[3.3.1]nonane – 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones. It is known that 3,7-diazabicyclononane derivatives have versatile biological activity, including showing antibacterial and fungicidal action. Previously obtained 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones were studied for the manifestation of fungicidal activity in vitro in relation to phytopathogenic fungi of various taxonomic classes, which are the main cause diseases of agricultural crops.

Purpose. To investigate the fungicidal activity of new derivatives of 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones on various phytopathogenic fungi, causative agents of the main fungal diseases of agricultural plants.

Materials and methods. The synthesized compounds were tested in vitro for fungicidal activity against seven fungi-phytopathogens of various taxonomic classes: V. inaequalis is the causative agent of apple scab, F. moniliforme is the main cause of fusarium diseases of cereal crops, R. solani is the causative agent of rhizoctonia, F. oxysporum, B sorokiniana - cause root rot, S. sclerotiorum is the causative agent of white rot, and P. ostreatus is the causative agent of tree stem rot. To determine the radial growth of mycelium, the fungal cultures were inoculated in agar nutrient medium with the addition of the test substance. The effective concentration of the drug in the sample was 30 mg/l. The suppression of fungal mycelium growth was calculated as a percentage using the Abbott`s formula. Measurements were carried out on the 3rd day. Commercial fungicides were selected as a comparison standard from the list of drugs presented in the State Catalog of Pesticides and Agrochemicals permitted for use on the territory of the Russian Federation.

Results. Most of the studied substances exhibit fungicidal activity. Some compounds have a pronounced fungicidal activity comparable to Russian commercial fungicides.

Conclusion. Thus, when studying the fungicidal activity of new 3,7-diazabicyclo[3.3.1]nonanes (bispidines) – 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones on various fungi-phytopathogens, it was shown that some of the obtained compounds have pronounced fungicidal activity and are promising for further testing.
LANDSCAPE AND FOREST RECLAMATION APPROACH TO ASSESSING THE STATE OF PROTECTIVE FOREST PLANTINGS
Authors: Rulev Alexander S. , Ruleva Olga V. , Rulev Gleb A. , Tanyukevich Vadim V.
Published: March 2022

Background. Previously, an inventory of protective forest belts was carried out, described within the boundaries of the administrative districts of the Rostov region. However, the forest-growing conditions of protective forest stands are determined by the landscape of the territory, so to assess the state of the Don-Salo-Manych interfluve, a landscape-forest-reclamation approach was used.

Purpose. On the basis of the landscape-forest-reclamation approach, the assessment of the state of protective forest stands was carried out, as well as the study of polygons using remote sensing data.

The novelty of research. For the first time, a landscape-catchment approach is applied to the assessment and grouping of protective forest plantations of the Dono-Salo-Manych interfluve of the Rostov region.

Materials and methods. Studies of the inter-river polygon of agroforestry landscapes were carried out on the basis of a cameral analysis of remote cartographic data and landscape-forest-reclamation interpretation of space photo information.

Results. There are 9 land-shaft areas with a weak and medium degree of land erosion. Test plots with model forest belts were laid out in each landscape area. The main tree species of protective forest belts is Robinia pseudoacacia (Robínia pseudoacácia), it occupies 65%. Оставшиеся 8% площади лесных полос относится к ясеневым (Fraxinus).

Conclusion. The landscape-forest reclamation approach to assessing the state of field-protective forest stands includes studying the features of micro- and mesorelief, the structure of the soil cover and assessing the state of forest stands, consisting in agroforestry landscapes of the prevailing species: robinia false acacia, squat elm and green ash. Robinia false acacia occupies 65-70% of the total plantation area. Elm trees occupy 27% of the total area of planted forests, dominated by mature and over-mature stands. This approach makes it possible to plan measures for the arrangement of the landscape territory, based on knowledge of forest growing conditions.
SIMPLE LINEAR AND MULTIPLE REGRESSION ANALYSES OF MORPHOLOGICAL TRAITS ON BODY WEIGHT IN FEMALE DORPER SHEEP LAMBS
Authors: Selala Lebelo J. , Tyasi Thobela L.
Published: March 2022

Regression is a very influential statistical technique that uses independent variables to describe the dependent variable. The present study was performed to determine the best-fitted model from different regression techniques to predict body weight (BW) from morphological traits viz. heart girth (HG), rump height (RH), body length (BL), withers height (WH) and sternum height (SH). Twenty-eight female Dorper sheep lambs at birth were used for data collection. The simple and multiple regression were used for data analysis. The coefficients of determination (R2) and mean square error (MSE) were used to determine the best-fitted regression model. The results indicated that in simple regression the best fitted regression model for estimation of BW in female Dorper lamb was the model including BL (R2 = 0.79, MSE = 1.43), in multiple regression, the best fitted regression model for estimation of body weight in female Dorper lamb was model including HG, RH, BL, WH, SH (R2 = 0.89, MSE = 0.90) in the study. The results of simple regression suggest that BL can truly estimate the body weight in female Dorper sheep lambs. Multiple regression findings suggest that two or more morphological traits can truly estimate body weight in the female Dorper lambs. The study will help the farmers to accurately predict the body weight of the Dorper sheep lambs using the morphological traits.
INFLUENCE OF GENDER, AGE AND METABOLIC FACTORS ON THE COURSE OF ARTERIAL HYPERTENSION IN PATIENTS WITH METABOLIC SYNDROME
Authors: Smirnova Olga V. , Moskalenko Olga L.
Published: March 2022

According to the World Health Organization, more than 2.1 billion adults are overweight, while about 600 million are obese. Arterial hypertension is a component of the complete metabolic syndrome, its severity, the possibility of effective correction depends on the severity of metabolic disorders in the patient.

The aim of our study was to study age, sex and metabolic parameters affecting the course of AH in MS in order to optimize therapy for patients with MS.

Material and methods. The study included 316 patients with hypertension and metabolic syndrome aged 35 to 65 years. The average age of the patients was 51.8 ± 6.4 years. In total, 154 (48.73%) women and 162 (51.27%) men were examined. The patients were divided into three age groups: group 1 – patients aged 35-44 years, group 2 – from 45 to 54 years old, group 3 – from 55 to 65 years old. Clinical examination of patients included a clinical-anamnestic method (collection of complaints and anamnesis, examination) and work with medical records.

The diagnosis of metabolic syndrome was verified based on the recommendations of the All-Russian Scientific Society of Cardiology (VNOK, 2009) if the patient had one main and at least two additional criteria.

The main criterion for MS was the “central” (abdominal) type of obesity; additional signs – arterial hypertension; increased TG levels; a decrease in the level of HDL cholesterol; an increase in the level of LDL cholesterol; an increase in fasting plasma glucose; impaired glucose tolerance.

For statistical processing of the research results, the Statistica for «Windows 10.0» software package was used.

Results. The development of hypertension in different age groups depends on a combination of various factors that are interrelated with age-related changes in the cardiovascular system and metabolic parameters, which in general characterizes the features of its clinical course. MS itself has a significant impact on the development of hypertension.

Conclusion. The comorbidity of obesity and the development of severe hypertension was revealed: there is an increase in the severity of hypertension with an increase in the degree of obesity. Age and obesity are both predictors of severe hypertension in MS. According to the predictive model, the following factors: male gender, with increasing age and degree of obesity, increases the likelihood of developing severe hypertension in MS. A comprehensive analysis of the total significance of risk factors, symptoms of target organ damage, taking into account age and gender factors, will make it possible to verify the individual variant of hypertension in MS, which will optimize the therapy of such patients and ensure a decrease in cardiovascular risk.
FEATURES OF THE CONSTITUTION IN WOMEN WITH VARIOUS TYPES OF LEFT VENTRICULAR REMODELING WHO HAVE CORONARY HEART DISEASE
Authors: Yaskevich Roman A. , Moskalenko Olga L.
Published: March 2022

Purpose. To study the constitutional features of the types of left ventricular (LV) remodeling in women with coronary heart disease (CHD) living in Central Siberia.

Materials and methods. The study included 220 women with isolated arterial hypertension (AH) and 160 women with AH in combination with CHD. We used the standard method of anthropometric research with the subsequent determination of constitutional types, as well as the determination of the types of geometric remodeling of the LV according to the ultrasound examination of the heart.

Results. The constitutional features of the frequency of unfavorable types of remodeling in women of the examined groups revealed. The largest group among the examined women with both isolated hypertension and hypertension in combination with CHD made up of representatives of the megalosomal type of constitution. LV remodeling detected in 91.6% of the patients with isolated hypertension and in 89.4% of women with hypertension in combination with CHD. At the same time, both among women with isolated hypertension and among women hypertension in combination with CHD, the most common type of geometry was concentric hypertrophy of the left ventricle. It found that for all constitutional types, patients with concentric hypertrophy of the left ventricle were more common.

Conclusion. Concentric hypertrophy of the left ventricle was more common in all constitutional types in women of both groups. Normal LV geometry more often observed in women isolated hypertension of indeterminate constitutional type and among women with hypertension in combination with CHD – megalosomal type.
Digital Literacy Curriculum Work Program for Primary General Education
Authors: Tsvetkova Marina
Published: March 2022

The program reveals the goals of mastering primary digital literacy by students in primary school, characterizes digital skills and determines the place of the digital literacy course in the curriculum, reveals the main approaches to the selection of course content and thematic planning, taking into account the hours chosen by the educational organization.
Digital Banking: Modern Finance Paradigm Shifting
Authors: Zaripov I.
Published: March 2022

The article provides an author's view of the current problems facing the banking system of the Russian Federation as part of the transition to digital banking services, especially aggravated due to the massive using remote channels of interaction due to the restrictions of the pandemic period. The author analyzes the current problems of financial sector due to increased criminal cyber attacks and offers recommendations to counter these crimes. There is evidence of the need to revise the concepts and strategies of the development of banks in connection with digitalization, to improve approaches to information security. And the author concludes that it is information security that is a key element in the process of digitalization of banking activities, and the soundness of banking institutions can be ensured only by the joint efforts of the state, banks and their customers, which will play a key role in stabilizing the domestic financial sector.
Assessment of the Influence of Economic Factors on the Mechanism of Settlement and Payment Circulation of Corporate Obligations
Authors: Morgoshiya G.
Published: March 2022

the article is devoted to the influence of factors on the mechanism of settlement and payment circulation of corporate obligations, which are differentiated by the author into three levels depending on the significance and breadth of coverage of the payment turnover of the enterprise and evaluated on the basis of the method of expert assessments. The article analyzes the accounts receivable, including overdue, of Russian enterprises over the past five years. The analysis showed the ambiguity of the results obtained by the years of the study period, where 2019 stood out vividly, characterized by the impact of the pandemic on the settlement and payment turnover of corporations. The author suggests external macro and meso-level factors, as well as internal micro-level factors, the evaluation of which by the expert method showed the priority of such parameters as: the level of solvency, the availability of the possibility of borrowing funds and the industry characteristics of the corporation. The last parameter gives a qualitative assessment of the influence of the studied factors.
Development and Assessment of the Economic Efficiency of Measures for the Development of Transport Logistics at the Regional Level
Authors: Bykova O. , Vedeneeva O. , Grigor'ev K. , Putihin Y. , Repnikova V.
Published: March 2022

The macroscopic transport model is the basis for developing scenarios for the development of transport infrastructure in any region. Further quantitative estimates of targets used in transport planning documents depend on the quality of the initial data preparation and the level of model calibration.

At the final stage, it is necessary to create a methodology for a comprehensive assessment of the economic efficiency of a set of measures for the development of transport logistics in the region, taking into account the costs and the possible socio-economic effect of their implementation, determined by the benefits received by the participants in the traffic. It should be understood that the effect can be difficult to formalize and heterogeneous for different categories of users of the transport system. It is assumed that due to the use of the macroscopic transport model of the region, the total effect will be defined as the ratio of the time savings expressed in monetary form for travel within the entire subject, which is planned to be obtained as a result of the implementation of the proposed measures.

The overall socio-economic effect is calculated for the period during which the repaired and newly commissioned transport logistics facilities will maintain a given quality of service level. In order to take into account the complex impact of the implementation of each of the proposed measures on the total time savings, they are entered into the model in accordance with the chronological order provided by the transport planning documents.
Bridging the Gap: Evidence from the Return Migration of African Scientists
Authors: Fry Caroline Viola
Published: March 2022

Although prior research has highlighted the benefits that accrue to brokers in innovation networks, much less attention is devoted to understanding who benefits from associating with a broker. This study focuses on the impact of associating with a specific kind of broker—a core/periphery bridge—that is, one that spans central and peripheral actors. I argue that actors associated with a core/periphery bridge benefit more when they have no central connection, or are outsiders in the network, due to their greater need for sponsorship from the broker. I explore this idea in the context of the return migration of American-trained scientists to African institutions, who span the core and the periphery of the global scientific network. I evaluate the impact of their return on the publication outcomes of nonmigrant scientists based in African institutions and find that following the arrival of a returnee in their institution, the nonmigrants who are not already connected to scientists in top global institutions have a greater publication output through improved access to central knowledge and connections. The findings contribute to a better understanding of how brokers can influence innovation systems more broadly.

Supplemental Material: The online appendices available at https://doi.org/10.1287/orsc.2022.1580 .
Revenue Management of Group Service Considering Different Quality Levels and Stochastic Customer Patience
Authors: Lin Xuxun , Wang Haiyan
Published: March 2022

We consider a service that provides different quality levels to customers who are served in groups (referred to as “group service” (GS)). We consider stochastic customer patience and build a multitype service model to maximize service profit. First, we consider a fixed number of service personnel and decompose the model into several subproblems. We then transform the model into a service personnel allocation problem that can be efficiently solved. Furthermore, we use the water-filling theory, together with a dichotomy approach, to design the numerical algorithm to conduct a numerical test based on actual data. The main contributions of this study are as follows. First, we provide the service provider with a service capacity allocation mechanism that can determine the optimal choice of service quality levels, number of service groups of different quality levels, time length of the service registration period, and service prices. Second, we find that under scarce service capacity, the single-type service can be more profitable than the multitype service, and low-quality services have higher marginal profits than high-quality services. However, when service capacity increases to a certain level, the multitype service can be more profitable than the single-type service. Third, we construct a service capacity decision mechanism and demonstrate the influence of service quality on the total number of service personnel and service groups. The conclusions are potentially useful to GS service providers to effectively make better managerial decisions and improve service profits.
Deceptive security to protect your business
Authors: Chambareau Eric
Published: March 2022

Information systems are being increasingly exposed to cyber attacks, intrusion attempts and sophisticated malware. For organisations, one of the main challenges associated with these risks is gaining a better understanding of the actors behind the threats, as well as the methods that they employ. So how can organisations gather information about the specific cyberthreats that they face and improve their threat intelligence strategy? One solution is a honeypot.
Agricultural robot wars
Authors: Marrow Charles
Published: March 2022

A great deal of investment and research is currently being funnelled into autonomous vehicles for farming applications – not only for production benefits, but also to secure them from cyber attacks in an effective and efficient manner. Some of these applications include automated irrigation, fertiliser and chemical deployment, automated weeding (by means of administering an electrical discharge to dismember the weed from the root) as well as autonomous harvesting using remotely controlled, GPS-tracked, heavy-duty autonomous vehicles. All of the autonomous devices are controlled using publicly accessible Internet highways and networks – but this leaves them vulnerable to malicious attacks, and therefore they are at risk of being hijacked or taken ransom.
Strength through simulation
Authors: Tankard Colin
Published: March 2022

Cyber defence costs rise every year as the number and sophistication of attacks grow. But simulating attacks could help to make you stronger.
The security implications of working-from-anywhere
Authors: Chapman Phil
Published: March 2022

The past 18 months have seen a shift by most organisations and companies to adopt a more hybrid approach to working, with over half of the UK workforce commenting that they would rather quit their job than return to the office. 1 In this period of the ‘Great Resignation’, organisations are under pressure to retain flexible and hybrid working. But for many this is coming at a cost, and that cost is to their security defences.
Experiment on the effect of Artemisia sieversiana extract on hair loss prevention and cell growth
Authors: Yang Seungbo , Jin Chul , Kwon Seungwon , Cho Seung-Yeon , Park Seong-Uk , Jung Woo-Sang , Moon Sang-Kwan , Park Jung-Mi , Cho Ki-Ho , Ko Chang-Nam
Published: March 2022

Objectives: This study aimed to examine the safety, effects on proliferation of hair papilla cells, and anti-inflammatory and antioxidant mechanisms of Artemisia sieversiana Ehrh. ex Willd. (AS) extract.Methods: Safety tests through purity testing, acute toxicity tests, and repeated toxicity tests were performed using AS extract (ASE) which had been dried for over two years. Cell culture and proliferation tests were conducted; VEGF (vascular endothelial growth factor), bFGF (basic fibroblast growth factor), and EGF (epidermal growth factor) and protein expression analyses were performed for mechanistic evaluation; and inhibitory effects of ASE on the RNA expression of testosterone, 5α-reductase, and aromatase was assessed. The anti-inflammatory and antioxidant efficacy of ASE was confirmed by measuring the levels of nitric oxide, inflammatory mediators (TNF-α and PGE2), inflammatory cytokines (IL-1β, IL-6, and IL-8), and chemokine MCP-1.Results: The safety of ASE was confirmed. The mechanism of cell proliferation in human hair follicle dermal papilla cells involved the promotion of VEGF, bFGF, and EGF expression. ASE decreased mRNA expression of testosterone, 5α-reductase, and aromatase-1 in a concentration-dependent manner. PGE2 and TNF-α production by inflammatory mediators was also significantly decreased in a concentration-dependent manner, and inflammatory cytokine and chemokine expression was inhibited.Conclusions: ASE is suggested to promote papillary cell growth at the cellular level, to suppress expression of various enzymes involved in hair cycle and cell death, and to inhibit hair loss through anti-androgen, anti-inflammatory, and antioxidant effects.
2 Cases of Sleep Disorder of Developmental Delayed Children Treated by Herbal medicine
Authors: Heo Yu Jin , Cho Yun Soo
Published: March 2022

Objectives: This study aims to find out the effect of herbal medicine on sleep disorder in developmental delayed children.Methods: 2 patients were treated by herbal medicine. For the progress evaluation, we used The Children’s Sleep Habits Questionnaire (CSHQ).Results: The clinical symptoms were improved after the treatment.Conclusion: This study reports that the herbal medicine improved sleep disorder in developmental delayed children, but further studies are needed to clarify the effectiveness of the treatment.
Harmful Effects of Social Research and the Universal Declaration on Bioethics and Human Rights
Authors: Mondragón Barrios Liliana , Guarneros García Tonatiuh , Jiménez Tapia Alberto
Published: March 2022

Risks and harms comprise a controversial topic in health sciences social research: they are minimised, denied, or not communicated to study participants. Article 4 of the UNESCO Universal Declaration on Bioethics and Human Rights stipulates the need to minimise harm, but this provision does not appear to refer directly to social sciences. Objectives: 1) to understand the harmful effects in social research; and 2) to describe the application of Article 4 to harm reduction in this field of research. Methods: We conducted an internet-based survey with social research investigators, asking about their experience and opinions regarding ethical practices in social research studies. Results: Respondents indicated that harmful effects were considered in terms of the repercussions of certain actions and decisions of the investigator, confirms risks such as the misuse and/or manipulation of information, the generation of false expectations of participants, the invasion of their space and privacy. The harms were disclosure of identity, violation of rights and the generation of stigma and prejudice; it brings in other types of harmful effects such as the self-interest of the researcher or his/her institution. Discussion: Social researchers observe Article 4, but this study questions aspects of the social and cultural context and their ethical repercussions.
Alternativas a los internamientos en salud mental: hospitalización domiciliaria desde la perspectiva española y anglosajona.
Authors: Noguero Alegre Alexandra , Peregalli Politi Santiago
Published: March 2022

En España, los internamientos por motivo de trastorno mental suelen implicar una perdida de libertades, ya que en general se realizan en unidades de puertas cerradas o bajo condiciones de carácter restrictivo. En este articulo se revisan las características de estos internamientos y la legislación española al respecto. Se realiza una comparativa con Reino Unido, donde se dispone de una ley exclusivamente dedicada a la salud mental, y se analiza el modelo anglosajón de hospitalización domiciliaria como alternativa al ingreso hospitalario. En conclusión, existe una mayor protección legislativa de los derechos fundamentales de los usuarios de salud mental en Reino Unido respecto a España. Es necesaria una reforma legislativa y el desarrollo de políticas sanitarias dirigidas a reducir los internamientos y fomentar otras alternativas de tratamiento. La hospitalización domiciliaria ha demostrado ser una alternativa eficaz al ingreso hospitalario, permitiendo tratar a la persona en el ambiente menos restrictivo posible y un mayor respeto de su autonomía.