bluuebunny/crossref_metadata_2025 huggingface dataset:
A macrophage related signature for predicting prognosis and drug sensitivity in ovarian cancer based on integrative machine learning
Authors: Zhao Bo , Pei Lipeng
Published: October 2023

Background

Ovarian cancer ranks the leading cause of gynecologic cancer-related death in the United States and the fifth most common cause of cancer-related mortality among American women. Increasing evidences have highlighted the vital role of macrophages M2/M1 proportion in tumor progression, prognosis and immunotherapy.

Methods

Weighted gene co-expression network analysis (WGCNA) was performed to identify macrophages related markers. Integrative procedure including 10 machine learning algorithms were performed to develop a prognostic macrophage related signature (MRS) with TCGA, GSE14764, GSE140082 datasets. The role of MRS in tumor microenvironment (TME) and therapy response was evaluated with the data of CIBERSORT, MCPcounter, QUANTISEQ, XCELL, CIBERSORT-ABS, TIMER and EPIC, GSE91061 and IMvigor210 dataset.

Results

The optimal MRS developed by the combination of CoxBoost and StepCox[forward] algorithm served as an independent risk factor in ovarian cancer. Compared with stage, grade and other established prognostic signatures, the current MRS had a better performance in predicting the overall survival rate of ovarian cancer patients. Low risk score indicated a higher TME score, higher level of immune cells, higher immunophenoscore, higher tumor mutational burden, lower TIDE score and lower IC50 value in ovarian cancer. The survival prediction nomogram had a good potential for clinical application in predicting the 1-, 3-, and 5-year overall survival rate of ovarian cancer patients.

Conclusion

All in all, the current study constructed a powerful prognostic MRS for ovarian cancer patients using 10 machine learning algorithms. This MRS could predict the prognosis and drug sensitivity in ovarian cancer.
Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers
Authors: Zollner Linda , Torres Diana , Briceno Ignacio , Gilbert Michael , Torres-Mejía Gabriela , Dennis Joe , Bolla Manjeet K. , Wang Qin , Hamann Ute , Lorenzo Bermejo Justo
Published: October 2023

Background

Latin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observational studies have found an inverse relationship between the individual proportion of Native American ancestry and BC risk. Here, we use ancestry-informative markers to rule out potential confounding of this relationship, estimating the confounder-free effect of Native American ancestry on BC risk.

Methods and study population

We used the informativeness for assignment measure to select robust instrumental variables for the individual proportion of Native American ancestry. We then conducted separate Mendelian randomization (MR) analyses based on 1401 Colombian women, most of them from the central Andean regions of Cundinamarca and Huila, and 1366 Mexican women from Mexico City, Monterrey and Veracruz, supplemented by sensitivity and stratified analyses.

Results

The proportion of Colombian Native American ancestry showed a putatively causal protective effect on BC risk (inverse variance-weighted odds ratio [OR] = 0.974 per 1% increase in ancestry proportion, 95% confidence interval [CI] 0.970–0.978, p = 3.1 × 10–40). The corresponding OR for Mexican Native American ancestry was 0.988 (95% CI 0.987–0.990, p = 1.4 × 10–44). Stratified analyses revealed a stronger association between Native American ancestry and familial BC (Colombian women: OR = 0.958, 95% CI 0.952–0.964; Mexican women: OR = 0.973, 95% CI 0.969–0.978), and stronger protective effects on oestrogen receptor (ER)-positive BC than on ER-negative and triple-negative BC.

Conclusions

The present results point to an unconfounded protective effect of Native American ancestry on BC risk in both Colombian and Mexican women which appears to be stronger for familial and ER-positive BC. These findings provide a rationale for personalised prevention programmes that take genetic ancestry into account, as well as for future admixture mapping studies.
The multi-kingdom microbiome of the goat gastrointestinal tract
Authors: Cao Yanhong , Feng Tong , Wu Yingjian , Xu Yixue , Du Li , Wang Teng , Luo Yuhong , Wang Yan , Li Zhipeng , Xuan Zeyi , Chen Shaomei , Yao Na , Gao Na L. , Xiao Qian , Huang Kongwei , Wang Xiaobo , Cui Kuiqing , Rehman Saif ur , Tang Xiangfang , Liu Dewu , Han Hongbing , Li Ying , Chen Wei-Hua , Liu Qingyou
Published: October 2023

Background

Goat is an important livestock worldwide, which plays an indispensable role in human life by providing meat, milk, fiber, and pelts. Despite recent significant advances in microbiome studies, a comprehensive survey on the goat microbiomes covering gastrointestinal tract (GIT) sites, developmental stages, feeding styles, and geographical factors is still unavailable. Here, we surveyed its multi-kingdom microbial communities using 497 samples from ten sites along the goat GIT.

Results

We reconstructed a goat multi-kingdom microbiome catalog (GMMC) including 4004 bacterial, 71 archaeal, and 7204 viral genomes and annotated over 4,817,256 non-redundant protein-coding genes. We revealed patterns of feeding-driven microbial community dynamics along the goat GIT sites which were likely associated with gastrointestinal food digestion and absorption capabilities and disease risks, and identified an abundance of large intestine-enriched genera involved in plant fiber digestion. We quantified the effects of various factors affecting the distribution and abundance of methane-producing microbes including the GIT site, age, feeding style, and geography, and identified 68 virulent viruses targeting the methane producers via a comprehensive virus-bacterium/archaea interaction network.

Conclusions

Together, our GMMC catalog provides functional insights of the goat GIT microbiota through microbiome-host interactions and paves the way to microbial interventions for better goat and eco-environmental qualities.
Carbon quantum dots as a tracer of water seepage sources and pathways in grottoes
Authors: Sun Bo , Ma Fenyan , Zhang Huyuan , Peng Ningbo , Zhang Peng
Published: October 2023

Water seepage is one of the main factors leading to the damage of grottoes. The sources and pathways of water seepage need to be identified to relieve it. Although the sources and pathways are investigated using geophysical exploration methods commonly, the results are unsatisfactory due to the limitation of resolution. The tracer method has been widely used to examine water seepage in the natural sciences and engineering. However, most tracers have an impact on grottoes, making this method inapplicable. This study was the first to use the carbon quantum dots as a tracer of water seepage in grottoes. The characteristics of the carbon quantum dots, which was synthesized by various biomass precursors through large-scale synthesis in the field, were analyzed to determine the optimal precursor. The structure, fluorescence intensity, and water solubility of the carbon quantum dots were evaluated. Laboratory tests were designed to examine the transport properties of the carbon quantum dots in rocks and cracks. The results showed that the carbon quantum dots synthesized by Ginkgo biloba were small and had uniform size, excellent fluorescence, good water solubility and transport ability. Furthermore, the carbon quantum dots were successfully used to tracing the source of water seepage at the chest of the Leshan Giant Buddha. The low cost of synthesis, wide precursors, easy and convenient synthesis methods, friendliness to grottoes, and excellent performance of the carbon quantum dots as a tracer suggest the efficacy of this method. These findings could lead to the widespread use of tracer method in studies of water seepage in grottoes.
Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy
Authors: Strong Thomas A. , Esquivel Juan , Wang Qikai , Ledon Paul J. , Wang Hua , Gaidosh Gabriel , Tse David , Pelaez Daniel
Published: October 2023

Background

Optic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not been fully elucidated. Several studies have identified ‘ephrin signaling’ as one of the most dysregulated pathways in the early pathophysiology of optic neuropathy with varied etiologies. Developmentally, gradients in ephrin signaling coordinate retinotopic mapping via repulsive modulation of cytoskeletal dynamics in neuronal membranes. Little is known about the role ephrin signaling plays in the post-natal visual system and its correlation with the onset of optic neuropathy.

Methods

Postnatal mouse retinas were collected for mass spectrometry analysis for erythropoietin-producing human hepatocellular (Eph) receptors. Optic nerve crush (ONC) model was employed to induce optic neuropathy, and proteomic changes during the acute phase of neuropathic onset were analyzed. Confocal and super-resolution microscopy determined the cellular localization of activated Eph receptors after ONC injury. Eph receptor inhibitors assessed the neuroprotective effect of ephrin signaling modulation.

Results

Mass spectrometry revealed expression of seven Eph receptors (EphA2, A4, A5, B1, B2, B3, and B6) in postnatal mouse retinal tissue. Immunoblotting analysis indicated a significant increase in phosphorylation of these Eph receptors 48 h after ONC. Confocal microscopy demonstrated the presence of both subclasses of Eph receptors within the retina. Stochastic optical reconstruction microscopy (STORM) super-resolution imaging combined with optimal transport colocalization analysis revealed a significant co-localization of activated Eph receptors with injured neuronal cells, compared to uninjured neuronal and/or injured glial cells, 48 h post-ONC. Eph receptor inhibitors displayed notable neuroprotective effects for retinal ganglion cells (RGCs) after six days of ONC injury.

Conclusions

Our findings demonstrate the functional presence of diverse Eph receptors in the postnatal mammalian retina, capable of modulating multiple biological processes. Pan-Eph receptor activation contributes to the onset of neuropathy in optic neuropathies, with preferential activation of Eph receptors on neuronal processes in the inner retina following optic nerve injury. Notably, Eph receptor activation precedes neuronal loss. We observed a neuroprotective effect on RGCs upon inhibiting Eph receptors. Our study highlights the importance of investigating this repulsive pathway in early optic neuropathies and provides a comprehensive characterization of the receptors present in the developed retina of mice, relevant to both homeostasis and disease processes.
Introduction to this special section: Deep exploration
Authors: Wang Chao , Graf Stephen , Li Chengbo
Published: October 2023

In the 1920s, the first oil discovery in Seminole, Oklahoma, was made at a depth of approximately 4000 ft using seismic reflection data. This breakthrough was achieved through the collaboration of Karcher's Geophysical Research Corporation and Amerada Petroleum Corporation. Today, J. Clarence Karcher's legacy lives on through SEG's prestigious annual award, presented to outstanding young geophysicists. Over the years, there has been a notable increase in the average depth of oil wells drilled. In 1949, the average depth was 3600 ft. By 2008, it was 6000 ft. As the consumption of oil and gas continues to grow globally, exploring deeper is a steady trend for hydrocarbon discovery. Currently the world's deepest oil well in Russia extends 49,000 ft into the earth's surface. Deep exploration below existing production, complex overburden, or at the limits of geophysical resolution is critical for existing and emerging ventures. To meet these challenges, researchers and geoscientists are actively working to acquire better data and develop innovative methods to improve imaging. Recent advances in hardware and equipment, data acquisition, algorithm development, computing, and digital technology allow for offshore and onshore exploration success and extended capability for exploration and production at higher efficiency in challenging deep environments.
Acquiring and processing deep dual-well DAS walkaway VSP in an onshore desert environment
Authors: Aldawood Ali , Shaiban Ali , Alfataierge Ezzedeen , Bakulin Andrey
Published: October 2023

This study describes the first successful dual-well distributed acoustic sensing (DAS) vertical seismic profiling (VSP) walkaway acquisition in two 4 km deep wells in an onshore desert environment in the Middle East. A dual-fiber interrogator enabled efficient recording of high-channel-count walkaway VSP that was suitable for robust velocity model building and imaging. A good signal-to-noise ratio (S/N) was achieved due to three main factors. First, the fiber cable that was deployed outside the tubing provided good receiver coupling. Second, a gauge length of 24 m was used as a natural receiver array, boosting the S/N. Finally, 16 sweeps per shotpoint were performed using two vibrators in the source array. The selection of optimal acquisition parameters enabled on-tubing fibers to record high-quality seismic signals down to about 4 km. Each shot was recorded by two fibers deployed in wells that are 1.5 km apart. Even with high-quality casing cementation, DAS records exhibited reduced sensitivity/coupling in the shallower section, requiring low-pass filtering for robust first-break picking. The corridor stacks at the two wells show an excellent tie to the surface seismic and agree with the zero-offset VSP geophone corridor stack at one of the wells. A massive ensemble of first-arrival picks enabled multioffset traveltime inversion to reconstruct a reliable velocity profile, approaching the sonic log and overcoming the lower sensitivity of DAS measurement at higher well deviation angles. We used the inverted velocity model to migrate the upgoing reflection response at the two deep onshore wells. The results demonstrate the ability of the dual-well DAS recording to obtain a high-resolution VSP subsurface migrated section with an estimated vertical resolution of about 15 m of reflections down to about 4 km.
Risk of mental disorders and malnutrition in elderly COVID-19 survivors: An observational study
Authors: Theresa Ria Maria , Dewiastuti Marlina , Ningsih Sri Rahayu , Safira Lisa
Published: October 2023

Background: The incidence rate of COVID-19 is around 11-15% in the elderly. The case fatality rate (CFR) of COVID-19 in the elderly is around 8.9% and increases with age. The risk of mental disorders and malnutrition is increased in COVID-19 survivors. Continuous inflammatory conditions result in a state of hypercatabolism that can disrupt brain neuroendocrine and protein consumption for the formation of acute-phase reactant proteins. Mental disorders and malnutrition can lead to fragility. The aim of this study was to assess the risk of mental disorders and malnutrition in elderly survivors of COVID-19.

Methods: This research was a cross-sectional study. The results of the research on age, disease symptoms, and comorbidities have proven that they are risk factors for mental disorders and malnutrition in elderly COVID-19 survivors. This study used total sampling and included 100 study subjects. The research was conducted in Depok for two months; data was collected directly through shared questionnaires and direct anthropometric measurements. The questionnaires used were the SRQ-20 tool for mental disorder screening and MNA for malnutrition screening.

Results: The risk factors for mental disorders were age over 70 years old OR 3 (CI 1.0-8.8), severe COVID-19 symptoms OR 4.5 (CI 1.2-16.17), and multi-comorbidity OR 2.3 (CI 0.6-8.8). The risk factors for malnutrition were age higher than 70 years old OR 2.5 (CI 0.8-7.9), moderate COVID-19 symptoms OR 6.3 (CI 2.0-19.81), and multi-comorbidity OR 6.6 (CI 1.5-28.5).

Conclusions: Those infected with COVID-19 have a risk of mental disorders and malnutrition, especially in geriatrics, and this risk increases with age.
ASEAN as network governance: An alternative lens to evaluate policymaking and performance
Authors: Sundram Pushpanathan
Published: October 2023

Background: This article offers a new perspective of the Association of Southeast Asian Nations (ASEAN) as network governance (NG) using the policy network theory (PNT) for the analysis.

Methods: Two case studies were selected from the ASEAN Community to examine the applicability and effectiveness of NG in promoting ASEAN cooperation. These case studies were chosen due to their prominence and the prevalence of critical comments about their effectiveness in promoting cooperation. The content analysis utilised primary data from ASEAN reports, documents, research articles and processes, and studies on NG and policy networks. A literature review was conducted using online academic databases and ASEAN-related websites. The search covered the period from June 2019 to March 2021, with further searches conducted between January and July 2023. These data collection efforts provided a robust analysis of the case studies within the NG and ASEAN integration contexts.

Results: The findings show ASEAN as a hybrid structure which has supported its survival and relevance. This approach provides legitimacy for ASEAN globally by purposefully adopting structures similar to the EU without the supranational elements. It also showcases ASEAN’s motivation for asserting its centrality. Adopting a hybrid structure has led to ASEAN's soft institutionalisation, driven by its norms and characterised by a less empowered secretariat, where the member states are the decision-makers and implementors of policies. It opens a pathway to recognising ASEAN states’ autonomy, where the actors’ will and interests affect decision-making and define performance.

Conclusions: This article demonstrates NG's viability in promoting ASEAN's centrality in regional cooperation and institutional arrangements and allows for a nuanced assessment of its performance considering the context of the issue and ASEAN's history and emphasising the member states' primacy in policymaking. The NG framework contributes to ASEAN’s legitimacy, regional cooperation and performance despite its inherent limitations.
Case Report: Medial prefrontal syndrome in a coup de sabre scleroderma carrier
Authors: Sanguino-Caneva Ciro , Carrillo-Chapman Carlos , Luque-Llano Melissa , Bermúdez Valmore , Vargas-Manotas Jose
Published: October 2023

Introduction: Linear scleroderma en coup de sabre is a subtype of scleroderma hallmarked by cutaneous and extracutaneous manifestations in which neurological symptoms can be a predominant feature of this condition.

Case presentation: We report a case of a previously healthy 47-year-old male who developed neuropsychiatric symptoms and right-sided cephalalgia for two months. Clinical examination revealed a right frontoparietal cutaneous lesion and neurological findings suggesting a medial prefrontal syndrome. The neuroimaging evaluation identified scalp and bone thinning adjacent to the skin lesion and cortical-subcortical white matter hyperintensity due to vasogenic oedema at the right frontal and parietal region. A biopsy from the affected area revealed reactive gliosis.

Conclusion: To our knowledge, this is the first linear scleroderma en coup de sabre report associated with a neurological involvement typical of a medial prefrontal syndrome. This case highlights the importance of clinical acuity in recognising atypical phenotypes within the spectrum of this uncommon disease.
THE IMPACT OF GENDER DIVERSITY ON THE QUALITY OF MANAGEMENT DECISIONS IN THE CORPORATE SECTOR
Authors: Izmaylova Marina Alekseevna , Korneva Evgeniya , Ziganshin Bulat , Dmitriev Andrey , Mardanov Ramis
Published: October 2023

The quality of management decision-making is determined by a number of factors, including the high competence of top management, its ability to adequately perceive and take into account the dynamism and instability of the external environment in the decision-making process for the purpose of flexible restructuring of business processes, and, if necessary, to adjust the company’s development strategy. In other words, competent leadership is a key factor in the quality of management decisions as a result of prompt, strategically verified and balanced adoption. At the same time, studying the quality of management decisions is impossible without taking into account the specifics of each individual company, its organizational structure, corporate culture, corporate communications system, management style, personal characteristics of top management, and gender diversity in the company's leadership. The study and synthesis of statistical data revealing the impact of gender diversity on company performance made it possible to provide a reasoned justification for the existence of a direct connection between the inclusion of women in directors and the profitability of companies. The combination of female and male mentality in company management allows us to find and apply new approaches to making management decisions that allow us to achieve all our goals. The success of many companies headed by women shows that it is largely predetermined by the personal qualities of women managers, manifested in the choice of behavioral models, preferences of methodological approaches to the management decision-making process, levels of adoption and types of decisions made, as well as their inherent personal authority and personal qualities. Gender diversity of the top management of companies allows us to minimize the possible deficit of the required personal qualities for making management decisions, which will inevitably lead to the effectiveness of the decisions made.
EMPLOYMENT AND UNEMPLOYMENT IN AGRICULTURE OF THE NORTH CAUCASUS FEDERAL DISTRICT
Authors: Tolmachev Mikhail , Gadzhimirzoev Gadzhimirze , Shaylieva Marina
Published: October 2023

Solving the problem of unemployment is a priority for the regions of the North Caucasus, where there is a significant shortage of jobs, which leads to labor migration of the population to other constituent entities of the Russian Federation. Finding solutions to increase the number of jobs is an important task that helps reduce unemployment in the regions of the North Caucasus Federal District. The work notes that the leading industry in the North Caucasus in terms of the number of jobs is agriculture, and currently there are significant reserves for growth in both the agricultural sector and processing industries, which are underdeveloped in the region. Agricultural products are mainly sold in unprocessed form, which leads to constant underutilization of existing processing capacities. One of the most obvious ways to develop the agro-industrial complex of the North Caucasus Federal District is to create favorable conditions for attracting large agricultural holdings to the region. Based on the results of the study, conclusions were drawn about the need to develop the processing of our own agricultural raw materials - primarily fruits, berries, meat, and milk. This is especially true in the context of economic sanctions directed against the Russian economy, as a result of which there is a risk of limiting the international supply of a number of food products, accordingly, the regions of the North Caucasus Federal District are able to replace most of them. These measures will not only strengthen the country’s food security, but will also lead to the creation of new jobs in the region, which will have a positive impact on the social situation in the North Caucasus.
GROWTH AND SURVIVAL OF THYME (Thymus L.) VARIETIES UNDER THE CONDITIONS OF THE NORTHERN TRANS-URALS
Authors: Gubanov Valeriy , Reneva Mariya , Gubanov A. , Gubanova V.
Published: October 2023

Thyme is a food, essential oil and medicinal plant, on the basis of raw materials from which drugs are created that have an astringent, anti-inflammatory, bactericidal, soothing and wound healing effect. Thyme essential oil is one of the strongest antioxidants and is used in medicine, perfumery, and the alcoholic beverage industry. The purpose of the research is to evaluate the survival rate and survival of thyme varieties in the conditions of the Northern Trans-Urals. The objects of research are eight varieties of creeping thyme (Purpurnyi fioletovyi, Mix, Limonchello, Ovoshchnoi, Raduzhnyi, Medok, Purpurnyi kover, Limonnyi) and one variety of early thyme (Creeping Red). The standard variety is Purpurnyi fioletovyi. The work was carried out in 2020-2022 in Tyumen region. Observations and records were carried out according to generally accepted methods. Meteorological conditions during the years of research differed significantly from the long-term average. According to the results of the assessment, out of the presented 9 varieties, the varieties Medok, Purpurnyi kover and Ovoshchnoi showed a higher survival rate. At the first laying in 2020, the survival rate of thyme was 88.4 ... 94.1%. In the second year of life, their survival rate was 40.8 ... 59.6% of the number of accustomed plants, in the third - 81.1 ... 93.1% of the number of overwintered plants. At the second laying in 2021, the survival rate varied from 44.0 to 73.3%. The number of surviving plants in the second year of life ranged from 26.4 to 68.3% of the number of established ones.
Dance Education in China (Between Traditional and International Aspects of Development)
Authors: Yuy Cyan'lun
Published: October 2023

The Chinese nation has a long tradition of dance education. Dance as a direction of art education integrates various aspects of personality development. Therefore, dance courses at colleges and universities have become popular among students in China. The courses help to improve body shape, develop temperament and contribute to the comprehensive development of students. Therefore, the Chinese government has always supported and developed dance education.

This article reviews the main aspects influencing the further development of dance education, in which various conflicting processes can correlate. China is a civilization that can correlate the contradictory processes associated with the development of unique aspects of culture (traditional) and universal (international).

The choreographic school of China is a multi-variant, unpredictable and complex learning process, in which the performing arts are filled with reverence for the national, and the educational function is filled with universalism. Consequently, China's modern dance education has not only deep national roots, but also international potential for genuine dialogue with other countries and civilizations.
Formation of a Teacher's Professional Identity: an Emotional Component
Authors: Ilyuhina A.
Published: October 2023

The article is devoted to the study of understanding the connections between the emotional development of a teacher and his professional identity. Twenty teachers of the first year of professional activity took part in a survey in order to identify an understanding of emotions that arise during professional activity, as well as how these emotions help them develop their professional identity. As a result of the study, a model of professional identity was obtained, which reflects the teachers' perception of themselves in connection with various emotional events. This model includes three key indicators: the initial orientation of the teacher's beliefs in understanding himself as a professional, the experience of pleasant/unpleasant emotional events, and the adjustment of identity. All participants demonstrated the role of emotional events in the development of their professional identity, and also suggested the need to use the data obtained in the professional training of future teachers.
Paweł z Zatora in castro Cracoviensi praedicator praefulgentissimus. W 560 rocznicę śmierci
Authors: Ćwiertnia Mieszko
Published: October 2023

This article is an attempt to present the teachings about the Immaculate Conception ofthe Virgin Mary proclaimed by the medieval Church in Cracow during the Councilof Basel. It is based on five sermons by Paweł of Zator, a canon of the Cracow CathedralChapter in the 15th century, where he served as an economist. Cardinal ZbigniewOleśnicki entrusted him, as his close collaborator, with tasks including the vicar’sduties in spiritualibus. Paweł of Zator, being an outstanding professor and a decretistat the Cracow Academy, was also assigned responsibilities related to the office ofpreacher in Wawel Cathedral. It is within the framework of fulfilling these duties thatthe sermons on the Immaculate Conception of the Virgin Mary discussed here werewritten. Therefore, this article is devoted to the figure of Paweł of Zator, with particularemphasis on his preaching achievements, especially his presentation of the positionof the Cracow Church community regarding the declaration of the Council of Baselon the Immaculate Conception of the Virgin Mary, as well as the cult surroundingit throughout ages in the Polish lands. Master Paweł’s sermons are discussed here interms of his theological workshop, especially as a biblical scholar and patrologist.
Biskup Marcin Szyszkowski a Krakowska Kapituła Katedralna
Authors: Wołyniec Bartłomiej M.
Published: October 2023

This article represents a modest yet clearly focused voice in the scope of research onthe history of the Cracow Cathedral Chapter during early modern times, a period inwhich its history was hardly studied at all. Consequently, it was even more difficultto make certain generalizations in this text, to a large extent due to the lack of sufficienttheoretical literature discussing the functioning of the chapter and its relationswith the bishop. Nevertheless, these relations have been outlined to a certain extent,preceded by the presentation of the profile of the article’s main protagonist, BishopMarcin Szyszkowski. As a result, both Szyszkowski’s involvement in the chapter’s workduring his affiliation with the corporation, and his relations as the head of the CracowDiocese with the chapter have been discussed.
Sebastian Sierakowski, Hartman Witwer i historia jednego nagrobka
Authors: Rostworowska-Kenig Weronika
Published: October 2023

The article is an attempt to examine four works – two drawings, a painting, and a sculpture– that share the same sepulchral composition design. One of the drawings, possiblya design of an executed tombstone, is the work of Sebastian Sierakowski, a Cracowcanon and architect educated in Lviv. The tombstone of Katarzyna Jabłonowska, néeOssolińska is attributed to the Lviv sculptor Hartman Witwer. The watercolor drawingand painting are anonymous works depicting the tombstone of Józef Thimi, sculptedby Witwer, from one of the cemeteries in Buda, Hungary, which shows similaritieswith Jabłonowska’s tombstone. The author attempts to arrange them in the correctorder and ponders their shared prototype. This brief text serves merely as an introductionto broader considerations of the sources of inspiration (previously describedonly as “Canovian patterns”) for the work of Witwer, who was educated in Vienna.
Ofiara Jadwigi i jej owoce. Wawelskie kazanie Jana Rostworowskiego SJ
Authors: Panuś Kazimierz
Published: October 2023

The 20th century was a time of intensified efforts to elevate Queen Jadwiga to the gloryof the altars. After the famous sermon by Rev. Władysław Bandurski (1865-1932),titled Let’s Awaken Jadwiga, delivered on 15 July 1905 in St. Mary’s Basilica in Cracowduring a service commemorating the Battle of Grunwald, another significantpreaching event was the Sermon for the Celebration of Queen Jadwiga by Father JanRostworowski, a Jesuit. It was delivered on 9 January 1933 at Wawel Cathedral, bythe tomb of Queen Jadwiga. By the decision of Archbishop Adam Stefan Sapieha ofCracow, the year 1933 was dedicated to the special veneration of the Angevin Queen.Rostworowski’s sermon revolved around the sacrifice made by Queen Jadwiga, whodedicated her life to the cause of the Union of Poland and Lithuania, and the magnificentfruits that emerged from it.
„Kiszka wawelska”, czyli pomieszczenie na murze obronnym zamku sąsiadującym z katedrą
Authors: Jakubczyk Ignacy
Published: October 2023

During the renovation of the Archive and Library of the Cracow Cathedral Chapter inthe years 2011-2015, the works were performed, among others in the loose documentstorage premises located east of the chapter house, in the corridor on the castle’sdefensive wall. After removing large shelves, access to the southern wall interior wasdiscovered, where three previously unknown small windows were revealed. As a resultof the commissioned inventory of the wall, a survey of the masonry, plasters, paintedfinishes, and chronological relationships between them was conducted in the corridor.The oldest threads dating back to the 14th and 15th centuries were identified, associatedwith the castle fortifications, the residence of Duchess Elżbieta of Ziębice,and the tower (present-day Zygmuntowska). The discovery of layers on the stonewall of the western side, linked to the duchess’s building, led to the formulation ofa hypothesis about the existence of a room of an unknown purpose there, predatingthe current layout of the corridor and its connection to the chapter house inthe 17th century.Attention was drawn to the position of lunettes in the vault, which did not correspondto the location of niches and windows on the southern and northern walls ofthe interior.Interesting results were obtained from the identification of the small windows inthe southern wall. One of them, the central one, opened into an unknown space in thepassage between the Lipski Chapel and the archive-library wall. It turned out that itused to be an entrance to the attic above the chapel. Observations allowed conclusionsto be drawn about the function of the window, the finishing of the southern facade ofthe archive-library before the creation of the passage, the construction of the discoveredroom, and its use.
Helena Modrzejewska – marka osobista miarą sukcesu
Authors: Kędziora Alicja
Published: October 2023

The article attempts to use the methodology and theory of brand management, in particular Pierre Bourdieu’s idea of capital, in the study of the life and work of Helena Modjeska. Using source materials, the author reconstructs the way Modjeska defined success and points out the financial, social and cultural resources she relied on to make it.
De los “márgenes” de la justicia al empoderamiento
Authors: Tierno Barrios Selena
Published: October 2023

En el marco de una investigación pionera, en el intento de trasladar al ámbito de la justicia penal la noción de exocanonicidad surgida en la literatura para referirse a aquellas escritoras y aquellos personajes femeninos que, silenciados y olvidados, han permanecido en los márgenes del canon dominante, se propone el análisis de la mujer como sujeto (exocanónico) de derecho en relación con el olvido tradicional y sistemático de la víctima en el sistema de justicia penal que ha derivado en el fenómeno de victimización secundaria que con más fuerza incide en el ámbito de la violencia de género. El objetivo del presente trabajo será analizar de forma crítica la situación particular de la víctima de violencia de género en el sistema de justicia penal español elaborando propuestas que permitan dar visibilidad y atender a su verdadera voluntad.
Incomplete Immunization and Chronic Energy Deficiency (CED) as Risk Factors for Stunting in Toddlers
Authors: Hafid Firdausi Ananda , Shoim Mohammad
Published: October 2023

Background: Stunting is a problem caused by long-term malnutrition so that at the age of 24-59 months the physical manifestations are more visible. Completeness of immunization and nutritional status of pregnant women are aspects that are risk factors for stunting. The prevalence of stunting in 2020 in the world reached 22%, while in Indonesia it is 30.8%. The purpose of this study was to analyze the relationship between the completeness of immunization and the nutritional status of pregnant women with the incidence of stunting in children under five aged 24-59 months. Method: The research method with this type of observational analytic research is a case-control approach. The sample size is 178, the sample is taken by purposive sampling, using secondary data obtained at the Wilangan Health Center. Results: Based on the chi-square test, it was found that there was a relationship between the completeness of immunization and the incidence of stunting with a value of p<0.001 (OR=12.63) and there was a relationship between the nutritional status of pregnant women and the incidence of stunting with a value of p<0.001 (OR=13.58). The results of the logistic regression test analysis showed a p-value <0.001 on the completeness of immunization and nutritional status of pregnant women for stunting with OR values of 5.71 and 5.52 respectively. Conclusion: There is a significant relationship between the completeness of immunization and the nutritional status of pregnant women with the incidence of stunting.
Ukraine – Yesterday, Today and on the Way to Revival
Authors:   Academy of Economic Sciences of Ukraine, Bilopolskyі M.
Published: October 2023

A critical analysis and review of the state of Ukraine's economy during the years of independence was made. The impact of foreign consultants and advisors is analyzed. A conclusion was made about the ineffectiveness of the political decisions made. Some ways to improve the current state are proposed.
Peculiarities of Project Cost Management
Authors:   LLC ", Povazhnyi O. ,   Technical University ",   Metinvest Polytechnic", Latysheva O. ,   LLC "Technical University "Metinvest Polytechnic", Moiseіenko K. ,   LLC "Technical University "Metinvest Polytechnic", Chupryna Yu. ,   LLC "Technical University "Metinvest Polytechnic"
Published: October 2023

The article defines the features of project cost management, provides examples of the use of project cost management tools. It is substantiated that understanding the peculiarities of project cost management is extremely important for project managers. It is proved that the use of modern project cost management tools is an important component of successful project implementation and achievement of goals. It has been established that it is necessary to carefully plan, monitor, and control costs at different stages of the project using modern tools and methods of resource management, namely Lean Six Sigma, Total Cost Management, Activity-Based Costing, Cost-Benefit Analysis, Value Management, Target Costing, etc., as well as using modern project digitalization programs (Microsoft Project, GanttProject, Primavera P6, Asana, Trello, etc.) that can be used to manage project costs, which allows you to effectively control and monitor project costs. The article provides examples of mistakes that can lead to an incorrect estimate of the project cost, which can lead to budget overruns, delays in the project schedule, and failure to achieve project goals. The article establishes that the main mistakes in planning the project budget may include: insufficient research of the factors of influence and forecasting shortcomings may lead to an incorrect assessment of the total project costs (some factors may not be taken into account, such as changes in market prices, changes in exchange rates, cost of resources, inflation, failure to take into account possible changes in technology, other factors and risks, such as changes in the timing, scope of the project); insufficient attention to cost minimisation opportunities (possibly not taking into account cost savings opportunities, such as the use of more efficient technologies or reduced material costs); underestimation of difficulties and possible changes (insufficient resource capacity, team qualifications or difficulties in collecting data, not taking into account changes in the market or technology, resistance to change) and other factors. It is proved that the use of modern project cost management tools will increase the efficiency of cost management and achieve success in project implementation.
Structural Models of Circular Bioenergy Clusters
Authors:   State Tax University, Lazarenko D. , Lіashenko V. ,   Institute of Industrial Economics of the NAS of Ukraine, Utkin V. ,   Institute of Industrial Economics of the NAS of Ukraine
Published: October 2023

The article examines the impact of the military conflict and the pandemic on the business environment of Ukraine, especially on the energy and manufacturing sectors. In the context of these changes, the need to develop cluster models and introduce circular bioenergy clusters turned out to be important. For the first time, Ukraine is implementing circular bioenergy clusters that provide cities with energy, solve waste problems and contribute to sustainable development. The study focuses on the bioenergy circulation of the Zaporizhzhya "Engineering-Automation-Machine Building" cluster, which even in the conditions of military conflict is successfully growing and developing, ensuring its energy independence through the production of biomethane. The research is aimed at determining the factors that will contribute to the sustainable transformation of business models of the Ukrainian circular economy in the context of modernization and post-war recovery. The article also emphasizes the development of a cluster ecosystem of startups aimed at using digital technologies and bioenergy resources. The importance of uniting clusters and cooperation with other regions to achieve common goals is noted. The authors consider various models of the organizational structure of circular bioenergy clusters in the context of their formation and development. The protocluster model, the monocentric model, the megacluster model, and the polycentric model are analyzed in detail regarding their features, advantages, and disadvantages. In general, the study reveals important aspects of the development of circular bioenergy clusters in the conditions of the double transition I5.0, taking into account the impact of military conflict.
The effects of workplace intervention programs to manage work-related musculoskeletal pain among poultry slaughterhouse workers: A randomized controlled trial
Authors:   Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand, Hancharoenkul Benjamaporn , Khamwong Peanchai ,   Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand, Pirunsan Ubon ,   Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand, Joseph Leonard ,   School of Sports and Health Sciences, University of Brighton, Robert Dodd Building, East Sussex, UK
Published: October 2023

Background: The prevalence rate of work-related musculoskeletal pain (WMSP) among poultry slaughterhouse workers (PSW) has been reported in the shoulder, arm, and hand due to the involvement of repetitive and forceful upper limb movements. An intervention program is needed to reduce upper limb pain and improve upper limb functions among PSW. Objectives: This study aimed to investigate the effectiveness of workplace intervention programs on musculoskeletal pain, upper limb functions, and work ability among PSW. Materials and methods: A total of 48 participants (21 males and 27 females) who met the inclusion criteria were recruited into the study. The participants were allocated into two groups: The workplace intervention group (WIG, N=24; 10 males; 14 females) and the control group (CG, N=24; 11 males; 13 females). The WIG performed the exercise training with elastic resistance bands (ERB) and stretching exercises for eight weeks, and the CG did not perform any activity. The Visual Analogue Scale (VAS), shoulder reach flexibility test, active range of motion (AROM), the disability of the Arm, Shoulder, and Hand (KKU-DASH), and Thai Work Ability Index (Thai WAI) were used as outcome evaluations. The two-way analyses of variance (ANOVAs) with repeated measures (group x time) were used for statistical analyses, and the statistical significance was set at p<0.05. Results: Approximately 79.1% (N=19) of the participants in WIG reported significantly decreased pain intensity of upper limb 3.06 (0.83 to -5.4) in the right side (p<0.01) and 1.96 (1.6 to -5.6) in the left side (p<0.001) after the 8-week intervention. Meanwhile, shoulder flexibility in WIG significantly increased (p<0.001) to around 3.55 cm. (0.67 to 8.20) on the right side and 5.61 cm. (2.0 to 10.67) on the left side. For AROM in WIG, neck flexion, lateral neck flexion, neck rotation, and left shoulder flexion significantly increased (p<0.05), as well as KKU-DASH and Thai WAI scores (p<0.001). There was no significant difference within-group in all variables in CG. Conclusion: The workplace intervention program significantly reduced upper limb pain and increased neck movement and shoulder flexion among PSW. The training programs also improved work ability and reduced disability with upper extremity musculoskeletal conditions among PSW.
Improving Yield Data Analysis Using Contextual Data
Authors: Hawkins Elizabeth M. , Buckmaster Dennis R.
Published: October 2023

Highlights

Context-driven yield data cleaning resulted in more accurate whole field yield estimates

Using a context-driven yield data cleaning method can improve yield estimates for zones within fields

Identifying error-prone areas in field where data quality is likely to be low and removing that data in bulk can reduce data cleaning bias

Abstract. As agriculture becomes more data driven, decision-making has become the focus of the industry and data quality will be increasingly important. Traditionally, yield data cleaning techniques have removed individual data points based on criteria primarily focused on the yield values themselves. However, when these methods are used, the underlying causes of the errors are often overlooked and as a result, these techniques may fail to remove all of the inaccurate (error-prone) data and/or remove legitimate data. In this research, an alternative to data cleaning was developed. Data integrity zones (DIZ) within each field were identified by evaluating metadata which included data collected by the combine that reported the operating conditions of the machinery (i.e., travel speed, crop mass flow), data about the field environment (i.e., soil type, topography, weather), and data of field operations (e.g., field logs, as-applied maps). Data in DIZ were isolated using buffers and the analysis of the reduced datasets was compared to the raw data. The amount of data removed depended on the amount of variability (e.g. soil characteristics, topography) in the field. Statistical comparisons of the data showed the mean yield estimates for soil type polygons increased by an average of 1.4 Mg/ha for corn when DIZ data was used compared to raw data. On average, the confidence around the mean remains similar even with a large amount (70%) of data removed. Notably, the none of the mean estimates derived from raw datasets were contained in the confidence intervals produced from DIZ data. This meta-data (context-driven) alternative to data cleaning effectively removed errors and artifacts from yield data which would only be identified when looking beyond the yield measurements themselves. When similarly reduced datasets are used to analyze historical yield data, they should provide a clearer picture of true yield effects of treatments, management zones, soil types, etc.; this will improve decisions on input and resource allocation, support wiser adoption of precision agricultural technologies, and refine future data collection. Keywords: Combine yield monitor, Context, Data analysis, Integrity zones, Management zones, Metadata, Precision agriculture, Yield, Yield data.