bluuebunny/crossref_metadata_2025 huggingface dataset:
Kampen om den organisatoriske selvfortælling - To skridt frem og to tilbage
Authors: Beyer Peter
Published: October 2018

Formand for Ledelseskommissionen Allan Søgaard Larsen siger følgende:"Det er nu, det virkelige arbejde med at forbedre ledelsen i den offentlige sektor begynder, for anbefalingerne er ikke meget værd, så længe de kun står i vores rapport. Den virkelige udfordring bliver at få dem ud og leve. Jeg er derfor glad for den positive modtagelse, og jeg håber, at politikerne over en bred kam vil arbejde konstruktivt for, at vi med udgangspunkt i vores anbefalinger får skabt endnu bedre ledelse i den offentlige sektor til gavn for borgerne,""Forandringer skal komme både fra lederne selv, der skal sørge for ’at ledelseskasketten vender rigtigt’, og så skal der over en bred kam skabes bedre rammer for lederne"Denne artikel handler om et projekt, der på mange måder minder om den opgave, som Ledelseskommissionen lægger op til. Projektet havde til formål at styrke den organisatoriske selvfortælling i en større kommune x, at få genrejst arbejdsglæden i kommunen, at frigive energi, positive tanker og stolthed omkring arbejdspladsen, at etablere en fælles følelse blandt alle medarbejderne, at medvirke til en opblomstring af lavtlønsområdet, at vise at alle er vigtige og at skabe effektivitet via stolthed og entusiasme.Artiklen beskriver et projekt, som var tæt på at komme i mål, men som alligevel ikke lykkedes. Beskrivelsen er forholdsvis detaljeret. Casen indeholder til sidst en række konkrete spørgsmål. Det er ikke meningen, at I som læsere skal svare systematisk på spørgsmålene, men vi håber, at de kan inspirere Jer til nogle generelle betragtninger og kommentarer. Vi håber at få nogle reaktioner fra Jer, som vi så vil samle i en efterfølgende artikel. Her vil vi anlægge et socialkonstruktivistisk perspektiv som udgangspunkt for en tænkt kulturforandring i kommunen. I kan sende Jeres tanker, vurderinger og løsningsforslag til Peter Beyer på mail pb.om@cbs.dk. Frist for indsendelse er en den 16. oktober 2018. Vi håber at få svar fra Jer, der gør det muligt at skrive en mindre artikel i næste nummer, som så vil indeholde resultatet af dialogen om processen med kommentarer fra Peter Beyer.
Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Authors: Davies Melanie J. , D’Alessio David A. , Fradkin Judith , Kernan Walter N. , Mathieu Chantal , Mingrone Geltrude , Rossing Peter , Tsapas Apostolos , Wexler Deborah J. , Buse John B.
Published: October 2018

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in 2012 and 2015, on the management of type 2 diabetes in adults. A systematic evaluation of the literature since 2014 informed new recommendations. These include additional focus on lifestyle management and diabetes self-management education and support. For those with obesity, efforts targeting weight loss, including lifestyle, medication, and surgical interventions, are recommended. With regards to medication management, for patients with clinical cardiovascular disease, a sodium–glucose cotransporter 2 (SGLT2) inhibitor or a glucagon-like peptide 1 (GLP-1) receptor agonist with proven cardiovascular benefit is recommended. For patients with chronic kidney disease or clinical heart failure and atherosclerotic cardiovascular disease, an SGLT2 inhibitor with proven benefit is recommended. GLP-1 receptor agonists are generally recommended as the first injectable medication.
The Canadian Chronic Disease Surveillance System: A model for collaborative surveillance
Authors: Lix Lisa , Ayles James , Bartholomew Sharon , Cooke Charmaine , Ellison Joellyn , Emond Valerie , Hamm Naomi , Hannah Heather , Jean Sonia , LeBlanc Shannon , Paterson J. Michael , Pelletier Catherine , Phillips Karen , Puchtinger Rolf , Reimer Kim , Robitaille Cynthia , Smith Mark , Svenson Lawrence , Tu Karen , VanTil Linda , Waits Sean , Pelletier Louise , O'Donnel Siobhan
Published: October 2018

Chronic diseases have a major impact on populations and healthcare systems worldwide. Administrative health data are an ideal resource for chronic disease surveillance because they are population-based and routinely collected. For multi-jurisdictional surveillance, a distributed model is advantageous because it does not require individual-level data to be shared across jurisdictional boundaries. Our objective is to describe the process, structure, benefits, and challenges of a distributed model for chronic disease surveillance across all Canadian provinces and territories (P/Ts) using linked administrative data. The Public Health Agency of Canada (PHAC) established the Canadian Chronic Disease Surveillance System (CCDSS) in 2009 to facilitate standardized, national estimates of chronic disease prevalence, incidence, and outcomes. The CCDSS primarily relies on linked health insurance registration files, physician billing claims, and hospital discharge abstracts. Standardized case definitions and common analytic protocols are applied to the data for each P/T; aggregate data are shared with PHAC and summarized for reports and open access data initiatives. Advantages of this distributed model include: it uses the rich data resources available in all P/Ts; it supports chronic disease surveillance capacity building in all P/Ts; and changes in surveillance methodology can be easily developed by PHAC and implemented by the P/Ts. However, there are challenges: heterogeneity in administrative databases across jurisdictions and changes in data quality over time threaten the production of standardized disease estimates; a limited set of databases are common to all P/Ts, which hinders potential CCDSS expansion; and there is a need to balance comprehensive reporting with P/T disclosure requirements to protect privacy. The CCDSS distributed model for chronic disease surveillance has been successfully implemented and sustained by PHAC and its P/T partners. Many lessons have been learned about national surveillance involving jurisdictions that are heterogeneous with respect to healthcare databases, expertise and analytical capacity, population characteristics, and priorities.
Institutional stakeholder perceptions on mobile number portability implementations in Georgia and Belarus
Authors: Ghalumyan Armen
Published: October 2018

Mobile number portability (MNP) is considered an important condition for ensuring full competition in the telecommunications sector, enabling mobile subscribers to change their service providers any time without altering their phone numbers. In global existence already since 1997, within the post-Soviet space it was first introduced only in 2011 and 2012, in Georgia and Belarus respectively. The given article summarises views and perceptions on MNP implementations of relevant institutional stakeholders from those two countries, i.e., mobile operators and national regulatory/ policy-making authorities in charge of the telecommunications field. It was part of a larger research project that studied also the perspective of final consumers (mobile users), which is outside the scope of the present publication.
Some closed-form solutions for buckling of straight beams with varying cross-section by Variational Iteration Method with Generalized Lagrange Multipliers
Authors: EROGLU Ugurcan , TÜFEKCİ Ekrem
Published: October 2018

This
study aims to derive approximate closed-form solutions for critical loads of
straight beams with variable cross-section. The governing equations are derived
for purely flexible beam for small displacements and rotation and turned into
non-dimensional form. Approximate solutions to the set of equations for stability
problems are searched by Variational Iteration Method with Generalized Lagrange
Multipliers. It turns out that highly accurate approximate buckling loads of cantilever
beams with variable section can be obtained in closed-form. Many novel
closed-form solutions for critical load of such structures, which may serve as
benchmark solutions, are presented.
Narcissus rupicola Dufour ex Schult. & Schult. fil. (Amaryllidaceae), novedad florística para Andalucía occidental (España)
Authors: Tirado Javier López
Published: October 2018

Narcissus rupicola Dufour ex Schult. & Schult. fil. (Amaryllidaceae), new record for western Andalusia (Spain)Palabras clave. Corología, Amaryllidaceae, Narcissus rupicola, novedad, Córdoba.Key words. Chorology, Amaryllidaceae, Narcissus rupicola, new record, Cordoba.
Monitoring Early-Life Mycotoxin Exposures via LC-MS/MS Breast Milk Analysis
Authors: Braun Dominik , Ezekiel Chibundu N. , Abia Wilfred A. , Wisgrill Lukas , Degen Gisela H. , Turner Paul C. , Marko Doris , Warth Benedikt
Published: October 2018

Infants are particularly susceptible towards the toxic effects of food contaminants including mycotoxins. However, multi-mycotoxin exposure assessment in breast milk has received very limited attention so far, resulting in a poor understanding of co-exposures during early-life. Here, we present the development and application of a highly sensitive, specific and quantitative assay assessing up to 28 mycotoxins including regulated (aflatoxins, ochratoxin A, deoxynivalenol, zearalenone) and emerging mycotoxins as well as key metabolites by LC-MS/MS. After careful optimization of the sample preparation procedure, a QuEChERS (quick, easy, cheap, effective, rugged and safe) protocol combined with a freeze-out step was utilized for method validation. The limits of quantification varied between 0.009 and 2.9 ng/mL, and for most analytes extraction recovery (74-116%) and intermediate precision (2-20%) were satisfactory. The method was applied to examine multiple breast milk samples obtained from 22 women (n=75 in total) from Ogun State, Nigeria. Most samples were either entirely free of mycotoxins or contaminated to a minimal extent with beauvericin (56%), enniatins B (9%), ochratoxin A (15%) and aflatoxin M1 (1%). The most abundant mycotoxin was beauvericin, which was not reported in this biological fluid before, with concentrations up to 0.019 ng/mL. In conclusion, the method demonstrated to be fit for purpose to determine and quantify low background contaminations in human breast milk. Based on the high sensitivity of the novel analytical method, it was possible to deduce that tolerable daily intake values were not exceeded by breastfeeding in the examined infants.
Persistent Homology for Virtual Screening
Authors: Keller Bryn , Lesnick Michael , Willke Theodore L.
Published: October 2018

Finding new medicines is one of the most important tasks of pharmaceutical companies. One of the best approaches to finding a new drug starts with answering this simple question: Given a known effective drug X, what are the top 100 molecules in our database most similar to X? Thus the essence of the problem is a nearest-neighbors search, and the key question is how to define the distance between two molecules in the database. In this paper, we investigate the use of topological, rather than geometric, or chemical, signatures for molecules, and two notions of distance that come from comparing these topological signatures. We introduce PH_VS (Persistent Homology for Virtual Screening), a new system for ligand-based screening using a topological technique known as multi-parameter persistent homology. We show that our approach can match or exceed a reasonable estimate of current state of the art (including well-funded commercial tools), even with relatively little domain-specific tuning. Indeed, most of the components we have built for this system are general-purpose tools for data science and will be released soon as open source software.
Gold Catalyzed Hydroamination of Propargylic Alcohols: Controlling Divergent Reaction Pathways to Access 1,3-Aminoalcohols, 3-Hydroxyketones or 3-Aminoketones
Authors: Laserna Victor , Sheppard Tom
Published: October 2018

A versatile approach to the valorization of propargylic alcohols is reported, enabling controlled access to three different products from the same starting materials. Firstly, a general method for the hydroamination of propargylic alcohols with anilines is described using gold catalysis to give 3-hydroxy imines with complete regioselectivity. These 3-hydroxyimines can be reduced to give 1,3-aminoalcohols with high syn seletivity. Alternatively, by using a catalytic quantity of aniline, 3-hydroxyketones can be obtained in high yield directly from propargylic alcohols. Further manipulation of the reaction conditions enables the selective formation of 3-aminoketones via a rearrangement/hydroamination pathway.
Isotopic Characterization (2H, 13C, 37Cl, 81Br) of the Abiotic Sinks of Methyl Bromide and Methyl Chloride in Water and Implications for Future Studies.
Authors: Horst Axel , Bonifacie Magali , Bardoux Gérard , Richnow Hans-Hermann
Published: October 2018

In this study we investigated the isotope fractionation of the abiotic sink (hydrolysis, halide exchange) of methyl halides in water.
Performance of Microporous Carbon Electrodes for Supercapacitors: Comparing Graphene with Disordered Materials
Authors: Mendez-Morales Trinidad , Ganfoud Nidhal , Li Zhujie , Haefele Matthieu , Rotenberg Benjamin , Salanne Mathieu
Published: October 2018

Over the past decades, the specific surface area and the pore size distribution have been identified as the main structural features that govern the performance of carbon-based supercapacitors. As a consequence, graphene nanostructures have been identified as strong candidates for maximizing their capacitance. However, this hypothesis could not be thoroughly tested so far due to the difficulty of synthesizing perfect materials with high pore accesibility and a sufficiently large density. Here we perform molecular simulations of a series of perforated graphene electrodes with single pore sizes ranging from 7 to 10 Angstroms in contact with an adsorbed ionic liquid, and compare the capacitances (using various metrics) to the one obtained with a typical disordered nanoporous carbon. The latter displays better performances, an observation that we explain by analyzing the structure of the liquid inside the pores. It appears that although the smaller pores are responsible for the largest surface charges, larger ones are also necessary to store the counter-ions and avoid the formation of detrimental opposite charges on the carbon. These results rationalize the need for disordered or activated carbon materials to design efficient supercapacitors.
Features of the clinical picture in patients of middle age with essential hypertension
Authors: Parfenov V A , Ostroumova T M , Ostroumova O D , Pavleyva E E
Published: October 2018

Aim. To evaluate the presence and the severity of the complaints (headache, dizziness, memory loss, concentration of attention, sleep disturbances, decreased mood, increased anxiety), the state of cognitive functions, emotional status and quality of night sleep in treatment-naïve middle-aged patients with mild to moderate EAH compared to healthy volunteers of the same age. Materials and methods. 103 treatment-naïve patients with EAH aged 40-59 years at the enrollment, who met the inclusion/exclusion criteria and provided written informed consent (46 men, mean age 53.6±0.8 years) and 50 healthy volunteers (17 men, mean age 51.5±1.0 years) with normal blood pressure (BP) level - control group - were enrolled to the study. Mean EAH duration was 2.9±5.7 years. Cognitive assessment included Montreal cognitive assessment, 10-words learning task, verbal fluency test, TMT, Stroop color and word test. Anxiety and depression were evaluated via Hamilton rating scales (HARS and HDRS). 24-hours ambulatory BP monitoring (ABPM) was performed according to European guidelines. Results. 70% of patients with EAH complained of memory disturbance, 68% - lack of attention, 22% - sleep disturbances, 12% - dizziness, 9% - headache. It took statistically significant more time for patients with EAH to perform on TMT B (p
Risk factors and in-hospital outcomes of acute kidney injury that developed after coronary artery bypass grafting in patients with stable angina
Authors: Kremneva L V , Suplotov S N
Published: October 2018

The aim of the study is to assess frequency, risk factors and in-hospital outcomes of acute kidney injury after coronary artery bypass grafting in patients with stable angina. Materials and methods. The study included patients with stable angina pectoris and indications for coronary artery bypass grafting. We examined 93 patients aged 58±7.6 years, with duration of coronary heart disease 6±6.0 years. Previous myocardial infarction had 79.6% of patients. Arterial hypertension was present in 92.5% of patients. Multi-vessel coronary disease was registered in 94.6%, stenosis of the left main coronary artery > 50% was in 16.1% of patients. Coronary artery bypass grafting in conditions of artificial circulation was performed in 89.2% of patients, coronary grafting on working heart was held in 10.8% of patients. At initial stage, on the first and second days after coronary grafting the level of creatinine was determined by the method of Jaffe. The presence, the severity of acute kidney injury after (AKI) coronary artery bypass grafting was evaluated according to the criteria KDIGO (2012). We took into account in-hospital complications: cardiac death, intraoperative myocardial infarction (iMI), stroke, atrial fibrillation (AF), acute heart failure (AHF) according to requirement in intraaortic balloon pump, and the use of adrenaline. Results. The proportion of persons with transient AKI stage 1 after coronary artery bypass grafting was 31.2%, those of 2 stage was 3.2%. The development of AKI was associated with cases of AHF. The increase in the duration of therapy with adrenaline - more than 1±1.8 days (median) - was connected with increase of the relative risk of AKI developing in 1.9 times. The incidence of cardiac death, iMI, strokes, paroxysmal AF did not differ among patients with AKI and without it. Conclusion. The frequency of transient AKI after coronary artery bypass grafting was 34.4%. The development of AKI is associated with AHF that occurred during coronary artery bypass grafting. The frequency of hospital complications did not differ among patients with AKI after coronary artery bypass grafting and without it.
Intravital and postmortem diagnostics of myocardial hypertrophy of the left ventricle:identity or convention?
Authors: Bogomolov S N , Kulikov A N , Tikhonova J A , Solntsev V N , Rybakova M G , Gudkova A Y , Kuchmin A N
Published: October 2018

The aim of the study is to assess the compliance of the results of electrocardiographic (ECG) and echocardiographic diagnostic methods of hypertrophy of left ventricular myocardium (LVH) with the postmortem finding of measurement of left ventricular myocardium mass (LVM). Materials and methods. We examined the data of intravital study of anthropometric measurements [age, height, weight, body mass index (BMI)], instrumental results [12-lead ECG, EchoCG], as well as the postmortem finding (direct measurement of LVM at autopsy) in 15 patients of general therapy department. While analyzing ECG we studied as conventional ECG criteria for the detection of LVH as well as the author's own criteria based on two models (regression and discriminant analyses), including voltage, sex and age criteria. Echocardiographic diagnostic method used to calculate LVM (according to ASE formula) and left ventricular mass index (LVMI). Postmortem finding of LVM was carried out according to the standard measurement method. According to the absence of the single conventional postmortem finding of measurement of LVH, we considered three different variants of the postmortem finding of LVH: the criterion of K. Bove et al. (CB); the criterion of A.M. Lifshitz, also called ventricular index (VI) and the criterion of P. Casale - the left ventricular mass index at autopsy (LVMI). Results and discussion. Conventional ECG criteria for the detection of LVH showed high specificity (71-100%) using any method of the postmortem finding of measurement, but were characterized by extremely low sensitivity (0-37.5%). Their overall diagnostic accuracy was higher on using K. Bove or A.M. Lifshitz criteria (40-66.7%) and low - on using the criterion of P. Casale (13.3-40%). The author's ECG criteria were less specificity (50-100%) and had higher sensitivity (54-75%), and their diagnostic accuracy remained higher and showed small dependence on the method of the postmortem finding of measurement of LVH (60-66.7%). Conclusion. Usually the ECG criteria to diagnose left ventricular hypertrophy were expectedly showed low sensitivity using any method of the postmortem finding of measurement. Meanwhile, the author's own ECG criteria associated with the most sensitive electrocardiographic characteristics to LVH and sex and age-specific indexes of the examined patients exceeded the conventional ECG criteria in sensitivity and diagnostic accuracy.
Estimation rate of S. aureus and MRSA carriage in diabetic type-2 and effect of Aspergillus Gliotoxin on bacterial carriage in type-2 diabetes
Authors: Al-Aajem Burooj M. Razooqi
Published: October 2018

Diabetes mellitus is a serious public health problem, S. aureus and MRSA are the most common bacteria isolated from ulceration of diabetic patients. The aim of the study was to estimation rate of S. aureus and MRSA carrier in diabetes type-2 and determine the antimicrobial effect of Gliotoxin on the previous bacterial carriage in type-2 diabetes. The study was conducted on 450 diabetics' patients, attended the outpatients clinic in Baquba Teaching Hospital, their ages ranged from 15-65years, with mean age of 36.15, and 150 healthy group, who were randomly selected, during the period from May 2016 to April 2017, patients were classified into two groups according to the type of diabetes, group1 included: 184 with type1-diabetes, and group2: included 266 with type2-diabetes, 97 patients with foot ulcers. Swabs were taken from anterior nares, toe and axillae for each diabetic patient type-2, identified based on standard bacteriological methods. Using the Kirby -Bauer method for detection the antibacterial effect of Gliotoxin. The results showed rates of the bacterial carriage in anterior nares of type-2diabetic patients without complications were (11.4%), (4.4%), respectively for S. aureus and MRSA, in type-2 diabetes with complications were (8.6%), (2.1%) respectively for S. aureus and MRSA. In the toe of type-2diabetic patients without complications were (6.7%), (2.5%) respectively for S. aureus and MRSA. In with complications were (9.2%), (5%) respectively. In the axillae of diabetic patients, type-2 without complications was (5.5%), (4.5%) respectively. Aspergillus fumigatusGliotoxin was effective against bacterial carriage in diabetes type-2 with the foot ulcer, for S. aureus inhibition diameter was (20.50, 16.40, 12.20) mm for different concentrations of Gliotoxin, to MRSA was (8.25, 6.1, 4.20) mm. Increasing rate of S. aureus and MRSA carrier in diabetic patient's type-2 which lead to a significantly increased risk of bacterial infections. Gliotoxin was effective as an antibacterial agent against S. aureus and MRSA in type-2diabetis with the foot ulcer.
FTIR-ATR spectroscopy as a diagnostic tool in the diagnosis of hypercholesterolemia induced by cholesterol-rich diet in rats
Authors: A Saira Khatheeja , A Safiullah , Krishna Mohan Surapaneni , V Vishnu Priya , AR Prabhakaran
Published: October 2018

Clinical Diagnosis is the process that identifies a possible disease or disorder that can be diagnosed through analysing specific components with multiple techniques and procedures that identifies the internal physiological changes. FTIR-ATR is a non-invasive, reagent-free diagnostic tool which can be rapidly and simultaneously analyze several components in the biological fluids and organs and which can be employed in analyzing the biomolecules. Hypercholesterolemia was induced in albino rats by feeding the animals with the regular diet supplemented with 1% cholesterol and 0.5 % cholic acid saturated with coconut oil for 6 weeks. End of induction study, experimental animals were sacrificed for biochemical and FTIR- ATR spectral analysis. Experimental serum samples were analyzed immediately for spectral recordings in the Mid IR region of 4000-450 cm-1. The intensity of the olefinic =CH bond (3012 cm−1) can be used as an index of relative concentration of double bonds in the lipid structure from unsaturated lipids. The C=O stretching at 1740 cm−1 monitor the glycerol backbone near the aqueous part of the lipids. Results on biochemical variations obtained with both these methods were compared. Based on results obtained the study suggest that the FTIR-ATR technique might be an additional technique to know more details at molecular levels in the diagnostic sector. Further, this technique could be standardised for routine utility in disease diagnosis and management in the medicinal field.
Crecimiento económico y el uso de energía sustentable y no sustentable: un enfoque del caso ecuatoriano usando técnicas de cointegración
Authors: Loaiza Verónica
Published: October 2018

La amenaza del cambio climático y la dependencia de las importaciones energéticas, junto al carácter agotable de los combustibles fósiles, han incentivado a muchos países a buscar fuentes de energía alternativas, esto con el fin de reducir las emisiones de gases efecto invernadero. Por ello, esta investigación analiza la relación de equilibrio existente entre la energía sustentable, no sustentable y el crecimiento económico de Ecuador durante el periodo 1971-2014. Utilizando datos del World Development Indicators del Banco Mundial y técnicas de cointegración para series temporales, encontramos evidencia que muestra que existe una relación de largo y corto plazo entre la energía sustentable, energía no sustentable y el crecimiento económico. También encontramos que existe una relación causal unidireccional desde la energía sustentable hacia el crecimiento económico. Lo que nos lleva a concluir que esta variable es de suma importancia para que exista mayor crecimiento económico, por esta razón hoy en día muchos países desarrollados están invirtiendo cada vez más en este tipo de energías limpias. Además de ayudar a disminuir la contaminación, también su costo está muy por debajo de las energías convencionales. Para el caso de Ecuador, ya se está trabajando en el cambio de la matriz energética, evidenciando grandes obras como los ocho proyectos hidroeléctricos, la mayoría de ellos ya en funcionamiento, por esta razón Ecuador se ha convertido en un país exportador de energía limpia. Una implicación política derivada de esta investigación es fortalecer tanto la oferta como la demanda de energías sustentables como mecanismo para robustecer el crecimiento económico de países que se encuentran en desarrollo.
Estrategias para fomentar la cultura tributaria desde la academia. Caso UTPL
Authors: Yaguache-Aguilar María Fernanda , Pardo-Cueva Mariuxi , Espejo-Jaramillo Lupe Beatriz
Published: October 2018

La finalidad de esta investigación es difundir las estrategias trabajadas desde la academia a través de los Núcleos de Apoyo Contable y Fiscal NAF, para fomentar la cultura tributaria responsable y voluntaria de las personas naturales no obligadas a llevar contabilidad en sectores vulnerables como: asociaciones de cafetaleros, adjudicatarios de los centros comerciales, artesanas de cerámica, asociaciones de la Mancomunidad Bosque Seco y de las Juntas Parroquiales de la Provincia de Loja. Las personas que forman parte de estos sectores carecen de conocimientos técnicos en el ámbito tributario y desarrollan sus actividades de manera empírica lo cual no les permite determinar de manera adecuada la rentabilidad de los productos que elaboran y por ende no cuentan con informes de los resultados económicos, factores que ocasionan un ambiente de desconfianza y desmotivación entre los miembros de las asociaciones. Estos sectores requieren de atención prioritaria no solo de los gobiernos seccionales sino también de la academia en virtud que desarrollan actividades económicas con productos propios de la localidad, por ello el interés de involucrar a estudiantes y docentes para fortalecer sus conocimientos, en el uso adecuado de los recursos mediante la aplicación de herramientas contables y administrativas básicas. La metodología utilizada es de tipo exploratorio-descriptivo; para levantar evidencias, se aplicó las técnicas de la encuesta y trabajo de campo, los datos se procesarón a través de métodos cuantitativos como el cálculo de frecuencias. De los resultados obtenidos se concluye que para fomentar la cultura tributaria se requiere de un trabajo conjunto entre la administración tributaria, la academia y la sociedad.
Facial Lesions in Children: Often a Challenging Diagnosis
Authors: Borges Ana Sofia , Brasileiro A. , Matos Pires E. , Baptista J. , Galhardas C. , Apetato M.
Published: October 2018

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Infundíbulo-Foliculite Disseminada e Recorrente em Idade Pediátrica
Authors: Miroux Catarino Alexandre , Dias Margarida , Viana Isabel
Published: October 2018

A infundíbulo-foliculite disseminada e recorrente é uma entidade rara de etiologia desconhecida, caracterizada clinicamente por uma erupção papular e folicular, e histologicamente por alterações espongióticas na porção infundibular do folículo piloso. Ocorre habitualmente em jovens adultos de fototipo V-VI do sexo masculino. Atinge frequentemente o tronco e membros, tem curso recorrente e caracteriza-se por fraca resposta à terapêutica. Descrevemos um caso de infundibulo-foliculite numa criança de 10 anos.
Multiple Eruptive Dermatofibromas in a Patient with HIV infection
Authors: Miroux Catarino Alexandre , Soares-de-Almeida Luís , Borges-Costa João
Published: October 2018

Multiple eruptive dermatofibromas is a rare event characterized by the appearance multiple dermatofibromas in few months. It is usually associated with immunodysregulation/immunosuppression. An appropriate work-up of underlying diseases must be done after this diagnosis, including search for HIV infection and lupus erythematosus. We present a case of multiple eruptive dermatofibromas in a female patient with HIV infection, possibly associated with a decrease in the CD4+ T cell count and viral load increase.
Projecto Angolano de Formação e Desenvolvimento da Dermatologia: Avanços e Desafios
Authors: P. de Almeida Voumard Lídia
Published: October 2018

Introdução: Apesar do fardo e das repercussões físicas, psicológicas e sociais que as doenças da pele representam, o desenvolvimento da Dermatologia e a formação de técnicos nessa disciplina defrontam em Angola sérios desafios, com repercussões no acesso e na qualidade dos serviços e cuidados prestados a população.Metodologia: Foi realizado um estudo retrospectivo do Projecto de Formação e Desenvolvimento da Dermatologia, iniciado em 2010 com o apoio do Ministério da Saúde e do Colégio Angolano de Dermatologia e Venereologia (CADV). O projecto tem por objectivo a formação de mais dermatologistas e de aumentar o acesso dos doentes a Serviços de referência. São apresentados dados sobre a formação dos internos, bem como outros ganhos e limitações do Projecto.Resultados: Até 2013, o internato médico complementar em Dermatologia estava reservado apenas a um Serviço de Dermatologia em Luanda, tendo formado oito dermatologistas desde 1975. Em 2013, cinco novos Serviços Regionais, abertos em Cabinda, Malange, Huambo, Benguela e Huíla, iniciaram a formação de especialistas, aumentando em 2017 a 26 o número total de internos em formação.Conclusão: No contexto de Angola, a descentralização dos serviços clínicos de formação, a afinação periódica do programa de pós-graduação e a promoção activa de atitudes e actividades de pesquisa são elementos chave no desenvolvimento da Dermatologia e na prestação de serviços de referência mais próximos das populações.
Immune Checkpoint Inhibitors in Melanoma: Review and Update
Authors: Matos Pires Eugénia , Moura Cecília
Published: October 2018

The overall increasing incidence of melanoma will very probably be the trend over the next two decades. This data stresses the need for new therapeutic resources, other than classic chemotherapy. Nevertheless, the treatment of advanced melanoma has been changed in the last decade due to novel therapeutic strategies, including immunotherapy with immune checkpoint inhibitors targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1). Inhibition of these targets enhances immune host response against cancer and results in durable objective responses, establishing immunotherapy as standard treatment for BRAF wild-type melanoma patients in advanced stages (III – unresectable and IV – metastases at distant sites). Anti-CTLA-4, ipilimumab, was the first–in-class immune checkpoint inhibitor to show improvement in overall survival in advanced melanoma. Latter, anti-PD-1 agents, nivolumab and pembrolizumab, have improved tumour response and tolerability in comparison with ipilimumab. Differences in outcome are expected considering the distinct target of checkpoint inhibition pathways. In this setting, it is of utmost importance the assessment of efficacy by combined therapy and the identification of biomarkers capable of predicting response to anti-CTLA-4 and anti-PD-1. After a previous review on cancer biology and mechanisms of action of immune checkpoint inhibitors we will focus on the main data on the immune checkpoint inhibitors for melanoma currently available in daily practice.
Class J Power Amplifier for 5G Applications in 28 nm CMOS FD-SOI Technology
Authors: Hanna Tony , Deltimple Nathalie , Fregonese Sébastien
Published: October 2018

With the ongoing race to deploy the fifth generation of wireless technologies, the research is directed towards the millimeter wave carrier frequencies as a result of the demand for high speed data and the need for more spectrum bandwidth. Beside the large bandwidth, one of the major challenges of the 5G is reducing energy consumption. The power amplifier is the most critical element of the radiofrequency front-end in terms of power consumption and bandwidth. In this work, we present the design of a wideband and highly efficient class J power amplifier. Post-layout simulation results show a broadband behavior over 12 GHz of bandwidth, with a power added efficiency of 38 % and a saturated output power of 16.2 dBm at 28 GHz. In addition, the linearity and the efficiency of the power amplifier are reconfigurable with to the back-gate of the 28 nm CMOS FD-SOI technology.
Properties of Soil in Najaf Governorate
Authors: Alsaedi Jamal K. , Hasan Nada M. , Hassan Raad G.
Published: October 2018

Eight soil samples were selected around Najaf governorate at depth levels 40-50 cm. X-Ray Fluorescence (XRF) was used to determine the concentrations of major and trace elements. Liner and mass attenuation coefﬁcient (µ, µρ) have been determined at gamma energies (662, 1172,1332) keV using NaI (Tl) detector. The range of linear attenuation coefficients for calculated samples were (0.553-1.163) cm-1, (0.122-0.178) cm-1 and (0.049-0.105) cm-1 at (662, 1172,1332) keV respectively. The range of mass attenuation coefficients obtained (0.39-0.76) cm2/gm, (0.087-0.117) cm2/gm and (0.0336-0.074) cm2/gm at (662, 1172,1332) keV respectively. The results showed that Fe content in the samples has a strong effect on the mass attenuation coefficient and this parameter is inversely proportional to the gamma energy.
A Comparison between Multi-Layer Perceptron and Radial Basis Function Networks in Detecting Humans Based on Object Shape
Authors: Jasim Saud Laith , Kudair Abass Zainab
Published: October 2018

Human detection represents a main problem of interest when using video based monitoring. In this paper, artificial neural networks, namely multilayer perceptron (MLP) and radial basis function (RBF) are used to detect humans among different objects in a sequence of frames (images) using classification approach. The classification used is based on the shape of the object instead of depending on the contents of the frame. Initially, background subtraction is depended to extract objects of interest from the frame, then statistical and geometric information are obtained from vertical and horizontal projections of the objects that are detected to stand for the shape of the object. Next to this step, two types of neural networks are used to classify the extracted objects. Tests have been performed on a sequence of frames, and the simulation results by MATLAB showed that the RBF neural network gave a better performance compared with the MLP neural network where the RBF model gave a mean squared error (MSE) equals to 2.36811e-18 against MSE equals to 2.6937e-11 achieved by the MLP model. The more important thing observed is that the RBF approach required less time to classify the detected object as human compared to the MLP, where the RBF took approximately 86.2% lesser time to give the decision.
On Î¸-Totally Disconnected and Î¸-Light Mappings
Authors: Jebur Ali Haider , Fadel Abass Huda
Published: October 2018

In our research, we introduced new concepts, namely *and **-light mappings, after we knew *and **-totally disconnected mappings through the use of -open sets.

Many examples, facts, relationships and results have been given to support our work.
Lactic Acid Bacteria Biosurfactant Role That Isolated from Human Breast Milk in Inhibit Eyes Pathogenic Bacteria
Authors: M.B. Muhsin Yusra , Z. Majeed Huda , Basim Mohammed Basam , A.A. Mohammed Salih
Published: October 2018

Biosurfactants have a wide-range of applications due to their unique properties like specificity, not toxicity (from LAB) and relative ease of preparation. These properties hold promise of biosurfactants to increase breast milk benefit were isolated and described into Lactobacillus plantarum, Lactobacillus fermentum ,Lactococcuslactis, and Leuconostocmesenteroides.The degree of microbial destruction of disease, which promotes  the effective remediation of disease spreading.This paper presents a review of available research, methods and publications regarding Biosurfactant extraction from Lactic Acid bacteria isolated from human breast milk. 3 samples of human breast milk was provided, LAB were isolated and described, Biosurfactants recovery and surface activity were tested and extracted endo and extra cellular. In other side 26 samples from eye patients were ordered, diagnosed and their sensitivity to biosurfactant were studied. The results showed that 5 isolates of LAB from human breast milk were biosurfactant producer but L. plantarum was the more efficiency in surface activity. In other side, out of 26 eyes sample 18 were positive to pathogenic bacteria included E.coli (7), Klebseilla (5), Staphylococcus aureus(3)and S.epidermides (3).Extracellular Biosurfactanthad good effect against tested bacteria, but endocellular (extraction by normal method) had not any effect against any bacteria, whereas by solvents method were the more active against all tested bacteria. The results are promising enough to continue the quest for enhancement of inhibition growth of pathogenic bacteria with biosurfactant application (extracted extracellular by solvents) to look forward for biosurfactant as a solution of antibiotic resistance problem. In this study we concluded thatL. plantarum was the more effectiveness in biosurfactant surface activity and the extracellular biosurfactant by solvent method for extraction were better than endocellular and normal method of extraction.
Development of Mobile Ground Control System and GPS Base Auto Tracking Antenna
Authors: Irwanto Herma Yudhi
Published: October 2018

Flight test of both rocket and high speed Unmanned Aerial Vehicle (UAV), which is currently developed by LAPAN, can not be separated from the need for a monitoring system of all the attitude of the vehicles. Utilizing and combining some of the available equipment components into a ground control system (GCS) equipped with GPS based auto tracking antenna, makes it easy in previous flight test activities that only do tracking antenna manually. This ground control system is equipped with automatic tracking antenna that always leads to the vehicle, so that the data attitude of flying the vehicle will be maximally monitored and analyzed directly with ease. This system has been tested on a laboratory scale related to testing using hardware in the loop simulation system
Comprehensive Surgical Management of Chronic Suppurative Osteomyelitis Extending to The Lower Border of Mandible – A Case Report
Authors: Kaul Deepak , Muddebihal Farahnaz , Chand Mohammed Anwar Ul Haque
Published: October 2018

Osteomyelitis of maxillofacial skeleton is common in developing countries such as India. This case report describes successful surgical treatment of chronic suppurative osteomyelitis {CSO} of the mandible of a 35yr old female. The precipitating factor was thought to be eventful extraction in the {left } posterior body at the inferior border of mandible.
Methods: Presurgical course of antibiotics ( Amoxycillin and metronidazole for 7 days and later followed by doxycycline for 1 month).Surgical debridement of the affected bone and reinforcing it with reconstruction plate using AO principles was done . Patient was kept on a high nutrient diet consisting of proteins.
Conclusion: The case report demonstrates the typical features of CSO . The combination of the antibiotics therapy and surgical debridement was successful in the treatment of chronic suppurative osteomylitis.
IMPLEMENTASI KURIKULUM 2013 PADA PEMBELAJARAN BAHASA INDONESIA DI SMA DI LOMBOK TENGAH
Authors: Susdiana Baiq Emilia , Hanafi Nurachman , Sudirman Sudirman
Published: October 2018

This study reports how attainments in the implementation of the 2013 Curriculum (K-13) in teaching bahasa Indonesia for SMA students. Using a survey method, this study assigned teachers, students, and administrators in SMAN 1 of West Brayat, Central Lombok Regency. The results show that handicaps do exist to teach bahasa Indonesia based on K-13 because: (1) teachers get problems on preparing teaching instructional designs and its attributes such as lesson plan, scientific approach teaching method, audio-visual toolkits, learning resources, and authentic assessment; (2) lack of understanding to perceive K-13 as an ideal curriculum that encourages students more active and self-independent learners; and (3) constraints appear in the implementation of K-13 include limited time, limited facilities and infrastructure, assessment, and activeness of students in the teaching and learning process.
Prediction of functional consequences of cerebral ischemic stroke one year after its occurrence
Authors: T. M. Cherenko  , Yu. L. Heletyuk
Published: October 2018

The aim —  investigation of independent prognostic factors of minimal dependence in everyday activities one year after ischemic stroke by developing a prognostic mathematical model.Materials and methods. The neurological and functional status of 150 patients (74 (49.3 %) women and 76 (50.7 %) men of mean age of (67.4 ± 0.7 years) with primary ischemic stroke and primary arterial hypertension in anamnesis was evaluated. Neurological deficit was evaluated by the NIHSS scale. The assessment of everyday life activity was provided by Bartel index (BI). The cognitive status was evaluated by MMSE scale. Diagnosis of hypertension was based on the results of clinical, instrumental examination and medical documentation. We applied daily blood pressure (BP) monitoring from the moment of admission every 4 hours for 6 days of acute period. The variability of SBP and DBP was determined by calculating the standard deviation for 6 days, as well as for the period from the first to the third and from the third to the sixth day.Results and discussion. A year after stroke, the median of the Barthel index values was 85, the minimum value was 45, the maximum — 100, the first quartile — 75, the third quartile — 95 points. Data on 105 patients with neurological deficit of moderate (82) and severe (23) degrees took part in the determination of the functional recovery prognostic predictors by BI. Of the 161 indicators that characterized the pathology and the results of an additional patient’s examination, 18 variables that had a reliable correlation with the BI score in a year were selected and involved in logistic regression analysis. According to the step­by­step analysis, (10 steps), the independent prognostic factors of minimal dependence in daily activities in a year were determined in patients with moderate and severe ischemic stroke: duration of hypertension (B coefficient = –0.11), thickness of the intima­media complex (B coefficient = –7.62), the MMSE score (B coefficient = 0.19), gender (B coefficient = –2.13), intake of sartans in combination with calcium antagonists or in monotherapy (B coefficient = –1.31), achievement of target BP in antihypertension therapy (its efficiency) (B coefficient = +2.95); constant — 7.43. The obtained model has a sensitivity of 95.3 %, a specificity of 88.9 % and a diagnostic accuracy of 93.4 %, an area under the ROC curve — 0.926 (95 % confidence interval: 0.881 — 0.972).Conclusions. The main tasks at the stage of rehabilitation of patients for achievement of a minimum functional dependence in a year in the case of moderate to severe ischemic stroke is to prevent the progression of the atherosclerotic process, improve cognitive functions and achieve the primary hypertension treatment effectiveness.
Hepatobiliary system surgery after operations on stomach and duodenum
Authors: O. M. Tyshchenko  , E. V. Mushenko  , R. M. Smachylo  , A. L. Sochneva  , I. B. Babinkina
Published: October 2018

The aim — to analyze the causes of biliary tract pathology after the stomach and duodenal surgery, and possibility for its correction.Materials and methods. The treatment results analysis of 46 patients with gallstone disease after operations on the stomach and duodenum was performed. Most of them have been operated for a complicated peptic ulcer. The complicated course of the early postoperative period was observed in 18 patients. The hepatopancreatic system disorders developed in the period from 14 days to 15 years after primary operation.Results and discussion. The extension of repeated surgical interventions depended on the revealed hepatopancreatotobiliary system pathology. Complications after repeated interventions were detected in 7 patients: bile leakage — 2, the postoperative wound suppuration — 1, pleurisy — 4 patients. 2 patients died after the operation.Conclusions. The main factors of the hepatobiliary system pathology after the stomach and duodenal surgery were: biliary tract iatrogenic damage, suture failure in pyloroplasty area or gastrointestinal anastomosis, sphincter of Oddi disorders and vagotomy. During repeated interventions on the biliary system, surgical tactics were chosen individually, depending on the signs detected at the preoperative and intraoperative stage. In case of necessary reconstructive interventions, the most justifiable was the Roux­en­Y choledocho/hepaticojejunoanastomosis.