bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting Phosphatidyl-inositol-4-Phosphate-5-Kinase ameliorates hepatic cancer by inhibiting PI3K/Akt/mTOR and autophagy mechanism and enhancing ROS-mediated apoptosis
Authors: A. Shantanu P. , Rajdev Bishal , Gangasani Jagadeesh Kumar , N.P. Syamprasad , Panda Samir Ranjan , Sarin S. K. , Tripathi Dinesh Mani , Andugulapati Sai Balaji , Naidu VGM
Published: February 2024

Background
Hepatic cancer cells control Reactive Oxygen Species (ROS) and lipid kinases to grow. PIP5K, a lipid kinase, modulates the proliferation and Autophagy; however, its role remains HCC progression is uncertain. This study examined the involvement of PIP5K in ROS-dependent autophagy-Nrf2 antioxidant pathways using α- and β-specific isoform inhibitors (ISA201IB and IITZ01) and discovered NG-TZ-17 and 20 as inhibitors under lead optimization from IITZ01.
Methods
PIP5K and its relationship with the ROS-Autophagy-Nrf2 axis were examined using western blotting and IHC in Hepatocellular carcinoma (HCC) tissue samples (n = 36) and hepatic cancer cell panels. To determine the role of PIP5K in ROS-mediated apoptosis, HepG2 cells (PIP5K highly expressed cancer cells) were treated with different amounts of H2O2 with and without PIP5K inhibitors and compared to a standard autophagy inhibitor. To support in vitro cell-based data, PIP5K inhibitors (IITZ01, 60 mg/kg and NG-TZ-17, 50 mg/kg) were orally administered for 10 days in a GFP-HepG2-induced hepatic cancer model in SCID mice. Animal imaging, tumor regression, survival, and protein expression in the isolated tumors were monitored.
Results
PIP5K isoforms, Beclin-1, and Nrf2 increased with HCC grade. Autophagy boosted the expression of PIP5K isoforms, Nrf2, HO-1, and SOD2, preventing peroxide-induced apoptosis. Under these conditions, PIP5K inhibitors increase ROS-mediated apoptosis by downregulating proliferation, autophagy, and Nrf2, indicating that PIP5K controls cellular proliferation, autophagy, and ROS-mediated apoptosis. In vivo research showed that PIP5K inhibitors (NG-TZ-17 and IITZ01) dramatically reduced the tumor burden in HepG2-xenograft SCID mice, comparable to sorafenib.
Conclusion
PIP5K isoforms induced hepatic cancer cell proliferation in response to ROS. Inhibition of PIP5K isoforms sensitizes hepatic cancer cells to ROS-mediated apoptosis by decreasing the PI3K/Akt/mTOR axis, autophagy, and Nrf2.
Pressure model and scaling laws in jammed bidisperse granular packings
Authors: Petit Juan C. , Sperl Matthias
Published: February 2024

This investigation delves into the scaling laws governing pressure and key mean variables
throughout the first and second jamming transitions previously observed in asymmetric bidisperse granular
packings. Motivated by a theoretical model integrating crucial parameters — size ratio, δ, concentration of small particles, XS, packing fraction, ϕ, mean contact number, ⟨Z⟩, mean overlap, ⟨αcn⟩, and mean branch vector length ⟨ℓcn⟩ — we employ molecular dynamics simulations to validate the model. Our findings reveal a nonlinear relationship between pressure and ϕ stemming from the dynamic interaction of mean variables with ϕ during compression. Regardless of XS for δ = 0.73, the scaling exponent cZ characterizing ⟨Z⟩ with ϕ consistently approximates 0.5, holding true for δ < 0.73
and high XS values. Intriguingly, for δ = 0.15 and low XS, where the two jamming transitions are observed, cZ exhibits distinct values. At the first transition, where large particles jam, cZ slightly exceeds 0.5, while it diminishes
to approximately 0.3 at the second transition following the jamming of small particles. Additionally, the exponents associated with the scaling of ⟨αcn⟩ and ⟨ℓcn⟩ with ϕ consistently converge around cα = cℓ ∼ 0.92 varying with changes in XS and δ. Moreover, the pressure model aligns seamlessly with simulation trends, exhibiting a consistent exponent around cp ∼ 1.1-1.3 throughout the first and second jamming transitions. These results offer valuable insights into the compression behavior of highly asymmetric bidisperse packings, emphasizing the substantial influence of δ and XS on the system’s macroscopic properties.
Patient Perspectives on the Role of Orthopedic Nurse Practitioners: A Cross-Sectional Study
Authors: Ben-Natan Merav , Revach May , Sade Or , Yanai Yaniv , Berkovich Yaron
Published: February 2024

Background: The inclusion of nurse practitioners (NPs) specializing in orthopedics shows potential for improving the quality of care for orthopedic patients. A critical aspect of assessing the feasibility and acceptance of introducing NPs into orthopedic settings involves understanding patients' perspectives on this role. This study aims to explore the receptiveness of orthopedic patients to treatment by orthopedic Nurse Practitioners (NPs). Additionally, it investigates potential associations between patients' willingness to engage with NPs, their familiarity with the NPs role, perceptions of nursing, and satisfaction with orthopedic nursing care.
Methods: This cross-sectional study involved patients admitted to an orthopedic department in a central Israeli medical center between January and February 2023. Data was collected using a questionnaire consisting of five sections, validated by content experts. Statistical analyses, performed using SPSS, included descriptive statistics, independent samples t-tests, Pearson correlations, and linear regression.
Results: In a diverse patient population, there was a moderate willingness for treatment by orthopedic NPs, with over two-thirds expressing strong openness. Patients exhibited high willingness for NPs involvement in various clinical tasks, yet lower for medication management and preoperative evaluation. Positive attitudes towards nurses and familiarity with the NPs role were significant predictors of patient willingness for NPs treatment.
Conclusion: Patient acceptance of orthopedic NPs varies across different aspects of care. While there is overall willingness to receive care from NPs, these nuanced preferences should be considered when implementing NPs in orthopedic settings. Awareness and positive perceptions play crucial roles in shaping patients' willingness to receive care from these NPs.
Trial registration: The research doesn’t report the results of a health care intervention.
Solitary thyroid nodule approach (radiological and surgical follow-up after resection), a practical study at Al-Mowasat University Hospital
Authors: khattab Khalid , Ahmad Nesrin , ALmidani Rawnak
Published: February 2024

Background
Thyroid nodules are common and can be benign or malignant. Solitary thyroid nodules (STN) have a high probability of being malignant and must be properly labeled for their correct management.
Methods and materials:
In this study, we analyzed the data of our departments over a period of six months. All patients who had a single thyroid nodule were included, and multiple nodules were excluded. The sample was collected in the Department of Radiology and General Surgery at Al-Mowasat University Hospital, based on the findings of the echograph.
Results
There were 125 cases of STN detected radiologically. By pathological anatomy, the percentage of presence of malignancy was 20%, the most common of which was papillary carcinoma 55%. The percentage of involvement of the right and left lobes was equal, the size of 1.5-3 cm was the highest at 67%, the percentage of presence of calcifications was 34. %, and the most common symptom associated with the lesion is goiter, accompanied by enlarged phlegm nodules at a rate of 46%, and according to the TIRADS classification, the most common is the fourth classification at 43%.
Conclusion
The single thyroid nodule in our study has a low probability of malignancy, echocardiography has a high degree of prognostication and patients should be further evaluated by ultrasound and biopsy.
Postpartum hysterectomy in the university maternity hospital (a retrospective statistical study)
Authors: yasmineh Mohannad mohammed nazir , Alhamwi Dalal mohamad emad aldin , albatahesh Basel essam
Published: February 2024

Objective
To study the file of patients who underwent obstetric hysterectomy and learn the indications, risk factors, and complications to reduce its occurrence as much as possible.
Type of study:
retrospective cohort study
Place of study:
Obstetrics and Gynecology University Hospital in Damascus - Records of the Archives Division.
Study period:
starting from 1/1/2016 until 12/31/2022.
Patients:
The study sample included 124 women admitted to the University Obstetrics and Gynecology Hospital who underwent obstetric hysterectomy.
Results
91.9.9% of the patients had a natural birth, while 8.1% had a cesarean section. The rate of performing a total hysterectomy was 1.47/1000, within seven years. The rate of it being performed among patients with a cesarean section was 3.12/1000, and the rate of it being performed among patients with a natural birth was 0.2/1000. The most common indication for a postpartum hysterectomy is placenta accreta (54%), and the most common complication of obstetric hysterectomy is urinary tract injury (22%).
Conclusion
Congenital hysterectomy is highly associated with cesarean section, and because of the high risk associated with cesarean section, the decision to perform cesarean section should be made when its benefits outweigh the potential risks.
Hydrocephalus, determining its classifications and causes
Authors: khattab Khalid , Zarifa Mohammed , Owaied Osama , Wahab Musaab Abdel
Published: February 2024

Aim: Studying hydrocephalus, determining its classifications and causes, as well as clarifying the diagnosis and treatment of hydrocephalus, and preventing hydrocephalus.
Methods: and materials: An operation was performed at Al-Mowasat University Hospital on /826/patients diagnosed with hydrocephalus by consulting the patient files in the Medical Records Department, while following up the cases with radiographs, plain, tomographic, and sonograms in the archives of the Radiology Division.
Results: We have found that the incidence of congenital hydrocephalus is greater than that in adults, in addition to the proportion of males being greater than the proportion of females, and that treating acute hydrocephalus results in faster recovery than treatment followed with chronic hydrocephalus, and that investigative diagnosis through axial computed tomography is the most successful method for diagnosing hydrocephalus. . The study also showed an emphasis on following up patients through radiological monitoring after installing the implant.
Conclusion: Magnetic resonance imaging gives much more information than CT scanning. Those in charge of treatment should pay attention to CT radiological monitoring after installing the mount.
Exploring the efficacy of naturally occurring C-C and C-O-C type biflavonoids towards the inhibition of MDM2-p53 interactions
Authors: Karmakar Suvankar , Majumdar Sourav , Singh Bula , Pramanik Anup , Mondal Samiran
Published: February 2024

P53-MDM2 protein-protein interaction (PPI) is one of the most well-established studied which is involved in human cancer. Most importantly, cell cycle and apoptosis are potentially regulated by the p53 protein. Minute double minute 2 (MDM2), the negative regulator of p53, induces p53 degradation and modulates its tumour-suppressing activity. Regaining p53 function by targeting and inhibiting the p53-MDM2 interaction for the treatment of cancer is a unique approach. In this present study, three C-C type biflavonoids (amentoflavone, robustaflavone and agathisflavone) and three C-O-C type biflavonoids (ochnaflavone, hinokiflavone and delicaflavone) were used as MDM2 inhibitors. Molecular docking and molecular dynamics (MD) simulation studies were done to show the p53-MDM2 inhibitory effect of six naturally occurring biflavonoid-based small molecules and determined the various possible conformations and binding affinity values and investigated the dynamic behaviour of MDM2-biflavonoid complexes. Both the C-C and C-O-C category of biflavonoids potentially inhibit p53-MDM2 interaction by blocking the p53-binding domain of MDM2. From the docking score, one of the C-C type biflavonoid, amentoflavone was found to be the strongest inhibitor i.e., strong binding affinity compared to the reference compound nutlin-3 towards MDM2 protein. MD simulation study showed similar RMSD, RMSF, RoG, and SASA profiles compared to the reference inhibitor nutlin-3, suggesting stability throughout the simulation time. These results indicate naturally occurring biflavonoids might be promising early lead compounds for the development of new anticancer agents targeting p53-MDM2 interaction, which to our knowledge has never been reported to disrupt p53-MDM2 interaction.
PTEKC: Pre-training with Event knowledge of ConceptNet for Cross-lingual Event Causality Identification
Authors: Zhu Enchang , Yu Zhengtao , Huang Yuxin , Gao Shengxiang , Xian Yantuan
Published: February 2024

Event Causality Identification (ECI) task aims to identify causal relations between events in texts, which is beneficial to understanding the precise logic meaning expressed by a text. Although existing event causality identification works based on fine-tuned PLMs have achieved promising results, they suffer from prohibitive computation costs, catastrophic forgetting of distributional knowledge, as well as poor interpretability. Particularly in low-resource and cross-linguistic scenarios, existing multilingual models are generally confronted with the so-called curse of multilinguality, language bias, and hence result in low accuracy and generalization ability. In this paper, we propose a paradigm, termed Pre-training with Event Knowledge of ConceptNet (PTEKC), to couple Multilingual Pre-trained Language Models (MPLMs) with external event knowledge for Cross-lingual Event Causality Identification. Specifically, we have developed a parameter-sharing adapter plugin that facilitates the integration of event knowledge into the frozen Pretrained Language Model (PLM). This approach significantly diminishes the number of trainable parameters and greatly reduces the risk of catastrophic forgetting. Our Adapter integrates multilingual-aligned event knowledge into the MPLMs through two designed pre-training tasks, namely span masking and self-supervised link prediction. Extensive experiments on the benchmark dataset MECI show that PTEKC is parameter-efficient and can effectively incorporate knowledge for improving cross-lingual event causality identification.
Immunomodulatory and antitumoral potentials of polyphenol-rich Salsola tetrandra leaf extract
Authors: Dakhlaoui Sarra , chaabani Emna , Nani Abdelhafidh , Ksouri-Megdiche Wided , Ksouri Riadh , Khan Naim Akhtar , Hichami Aziz
Published: February 2024

This study explored the influence of Salsola tetrandra leaf polyphenol-rich extract (STLPRE) on RAW 264.7 macrophage polarization and its potential antitumoral effects on transplanted mouse melanoma cells (B16). The phenolic contents and antioxidant activities of STLPRE were initially assessed. Furthermore, the immunomodulatory impact of STLPRE on RAW 264.7 cells and its in vitro and in vivoantitumoral effects against B16 cells were investigated. Exposing RAW 264.7 cells to STLPRE (10 and 30 µg/ml) upregulated conventional activated macrophage (M1) markers, including TNF-α, IL-1, IL-6, IL-12, Arg2, NO, and iNOS, with significant increases in NF-κB (p65) and MAPKs (ERK2, p38, JNK) activation. STLPRE also reduced M2 markers, decreasing Arg1 and CD206 mRNA expressions. Pro-inflammatory cytokine mRNA expression was less pronounced in STLPRE-treated macrophages than in LPS-stimulated cells. Notably, IL-1, IL-6, and IL-12 mRNA expressions in LPS-stimulated cells were approximately 60 %, 186 %, and 244 % higher than those in STLPRE-treated cells (30 µg/ml). In LPS-stimulated macrophages, STLPRE treatment significantly decreased nitric oxide (NO) production and M1 markers expression in a dose-dependent manner, concurrently inhibiting NF-κB phosphorylation. Interestingly, STLPRE or supernatant from STLPRE-treated macrophages reduced B16 viability in vitro and inhibited B16 tumor growth in C57BL/6 mice. This reduction in B16 tumor growth was associated with increased splenic mRNA expression of IFN-γ, IL-1, and IL-12 in STLPRE-treated mice. Our findings suggest that STLPRE represents a promising source of antitumoral biomolecules.
The assessment of leukocyte systemic inflammation index ratios in dyslipidemia patients with dry eye disease
Authors: Alhalwani Amani , Hafez Salwa Y. , Jambi Shatha , Alsubaie Nasser , Rayani Khalid , Alqanawi Yamin , Alkhomri Ziyad , Hariri Saden
Published: February 2024

Background
One of the many adverse effects of dyslipidemia (DLP) is dry eye disease (DED), which is brought on by metabolic syndrome and increases inflammation. This research aimed to assess the leukocyte systemic inflammation index ratios in DLP with DED (DED-DLP) as potential biomarkers of systemic inflammation.
Methods
Several sets of blood biomarkers were studied. There were specific leukocyte profile parameters (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte*platelet ratio (NLPR)); the lipid profile (levels of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides): and an inflammation marker (C-reactive protein (CRP)). These were evaluated in 32 patients with DED-DLP (study group) and 52 subjects without DLP (control group).
Results
The study group had significantly greater levels of monocytes and CRP than did the control group (p = 0.024 and 0.049, respectively). A negative correlation with a statistically significant difference between HDL and NLPR (p = 0.007; r=-0.428) and a negative correlation with a statistically significant difference between albumin levels and PLR values (p = 0.008; r=-0.420) were seen as predictors of DED-DLP.
Conclusion
Individuals with DLP are more likely than those without the condition to experience DED because the levels of their leukocyte systemic inflammation index ratios reflect the seriousness of systemic inflammation. The study found that CRP and NLPR levels might be helpful as predictors of the likelihood of the development of DED by DLP patients. Additional research is needed to determine the additive contribution played by leukocytes and the significance of NLR, PLR, and MLR.
In-silico Drug Repurposing Pipeline for Epilepsy: Integrating Deep Learning and Structure-based Approaches
Authors: Guo Jinjiang , Lv Xiaoying , Wang Jia , Yuan Ying , Pan Lurong
Published: February 2024

Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this disorder. This study leverages the transformer-based deep learning methods coupled with molecular binding affinity calculation to develop a novel in-silico drug repurposing pipeline for epilepsy. The number of candidate inhibitors against 24 target proteins encoded by gain-of-functon(GOF) genes implicated in epileptogenesis ranged from zero to several hundreds. Our pipeline has repurposed the medications with most anti-epileptic drugs (AEDs) and nearly half psychiatric medications, highlighting the effectiveness of our pipeline. Furthermore, Lomitapide, a cholesterol-lowering drug, first emerged as particularly noteworthy, exhibiting high binding affinity for 10 targets and verified by molecular dynamics (MD) simulation and mechanism analysis. These findings provided a novel perspective on therapeutic strategies for other central nervous system (CNS) disease.
Merging Mixture of Experts and Retrieval Augmented Generation for Enhanced Information Retrieval and Reasoning
Authors: Xiong Xingyu , Zheng Mingliang
Published: February 2024

This study investigates the integration of Retrieval Augmented Generation (RAG) into the Mistral 8x7B Large Language Model (LLM), which already uses Mixture of Experts (MoE), to address its existing limitations in complex information retrieval and reasoning tasks. By leveraging the Google BIG-Bench dataset, we conducted extensive quantitative and qualitative analyses to evaluate the augmented model's performance. The results demonstrate significant improvements in accuracy, precision, recall, and F1 score, highlighting the enhanced model's superior capability to generate contextually rich, accurate, and nuanced responses. This integration showcases a promising approach to overcoming the intrinsic limitations of traditional LLMs, marking a pivotal advancement in artificial intelligence research. Our findings contribute to the ongoing development of more adaptable, efficient, and intelligent AI systems, opening new avenues for AI application across various fields. The study acknowledges limitations related to dataset scope and computational demands, suggesting directions for future research to further refine and expand the model's applicability.
The Effectiveness of Food Vlogger Review on Purchase Intention Toward Food Product (Study on Mega Influencer)
Authors: Dewanthi Desyra Sukma
Published: February 2024

Objectives: The objective of this research is to investigate the factors, such as source credibility (attractiveness, trustworthiness, and competence) and brand-influence match up congruence, that might contribute to better customer attitudes and buy intentions. The study is focused on millennials and Gen Z between the ages of 18 and 34 who have recently seen food vloggers review products on Youtube.

Method: This research utilizes using an online questionnaire that is made with Google Form distributed to 265 respondents. The full-scale data is analyzed through SmartPLS and bootstrapping analysis to test for reliability, validity, and the research’s hypotheses to identify the relationship between variables.

Results: The findings of the research shows that trustworthiness, expertise, similarity, liking, and familiarity value has a positive and significant relationship with customer attitude toward food product. Customer attitude toward food product also has a positive and significant relationship with purchase intention. Then both Attractiveness and Brand-Influencer Match-up does not have a positive influence significant effect on customer attitude toward food product.

Conclusion: The results of this research, it can be concluded there are 6 variables that measure food vlogger reviews that are included in the source credibility model, namely trustworthiness, attractiveness, expertise, liking, familiarity, and similarity. The more trustworthiness, expertise, similarity, liking, familiarity felt by food vloggers by customers, the more positive customer attitudes towards food products will be.

 

 

Key words:

Youtube, Food vloggers, Food Product, Customer Attitude, Purchase Intention
Dinamika Pertumbuhan Ekonomi di Provinsi Banten: Analisis Data Triwulanan 2018-2022
Authors: Gentar Muhamad , Permatasari Intan , Kautsar Wildan
Published: February 2024

This research aims to examine the dynamics of economic growth in Banten Province in the period of 2020-2023, using quarterly data obtained from the Economic Report of Banten Province published by Bank Indonesia. This research uses a descriptive-analytical method with a quantitative approach. The variables used are economic growth, inflation, banking intermediation, and regional budget expenditure. The results show that economic growth in Banten province tends to increase and is higher than national and regional economic growth in Java, although it is still influenced by factors such as inflation, banking intermediation, and regional budget expenditure. This research contributes to the development of the economy in Indonesia, especially in Banten province.
Internal Marketing Strategies and Employee Satisfaction: Perceived Efficacy with Workforce in New Normal
Authors: Srivastava Abhishek , Goyal Mukta
Published: February 2024

Many new and abnormal solutions turn into new standards with a deeper understanding of the connection with the lockdown scenario in COVID-19. However, with loads of problems, we have managed to turn our business with new dealings followed by varied mysteries. Undoubtedly, we are now turning into a noble mechanism to drive in the direction of finding conclusive and ground-breaking results for the mass concerns in association with internal marketing communications. Updated information now covers the promotions and correspondence business of the current new normal-like situation. Communication helps in understanding workers' awareness, habits, interests, preferences, and feelings as essential ingredients to preserve integrity from an introspective perspective. Internal communication is the connection that links emotions and behaviors in a contemporary work environment. The study's objective is to identify efficacious internal marketing techniques adopted by different prominent organizations in post COVID-19 era and compare strategies adopted with internal marketing in pre- and Post-Covid situations for employees. Despite challenges faced by organizations which are unparalleled to the existing scenario and can pretend like devastating effect in the pandemic situation, here in this paper, researchers have tried to drag the concepts of disruption of services with different prominent organizations in connection with the management of sales along with the requirements to manage the workforce to induce them to operate remotely and off-course in analyzing situations. Researchers have also focused on issues like the health and welfare of workforces and significant contributions to society. Now communication plays a key role in the pandemic situation, and the integration of technologies now serves as a major rescuer. The study showed that in-house communication professionals play a significant role in their entire organization since they collaborate with other staff to ensure that companies run as smoothly as possible. It also states that this epidemic leads management teams to notice that businesses cannot expand, succeed, or prosper without consciousness, commitment, and diligent staff, ultimately giving people the feeling of knowing products with virtual reality.
Business Intelligence Implementation: A Global Ethical Challenge in Current Scenario
Authors: Gupta Ekata , Jain Shipra , Dokania Nilesh K.
Published: February 2024

The new Corona virus pandemic is having unprecedented impacts across the globe, especially on human health and economic activities. In this context, governments are totally focusing on digital world and for this Business Intelligence plays the most important role. While business intelligence is a bright and prosperous tool for innovative entrepreneurs, data analysts, or business leaders looking to evolve their efforts, with innovation comes a range of challenges – issues that you will have to tackle to progress and squeeze the most value from your data. Like many other business decisions, these strategies will vary from one company to another based on the business’s size, industry, and culture. The trend in business intelligence and analytics is toward self-serve strategies that incorporate business users into the landscape of analytics with easy-to-use, mobile tools that they can leverage to make better decisions. A BI tool should be flexible for personalization and it should be something your users will want to adopt. A cost-effective business intelligence solution should be for every user.2-5
Evaluating Risks of Hyperinflation Post COVID-19 Pandemic
Authors: Kumari Santosh , Singhal Vranda , Majumder Ritabrata
Published: February 2024

The COVID-19 pandemic represented a logical Catch 22 scenario in the world of financial economics. The pandemic saw a sudden and unanticipated plunge in Money Velocity, Consumer Confidence, Employment, and Industrial Output. At the same time, due to fiscal and monetary stimulus measures in the form of quantitative easing and stimulus checks, the US saw an unanticipated rise in its Money Stock. With new waves of the virus and long-lasting labor shortages, a possible surplus liquidity scenario might arise. The United States faces a potentially high inflation rate scenario in such a case. This study draws insights from similar historical precedents and aims to model inflation as a function of macroeconomic variables: unemployment, money stock, money velocity, and industrial production. The study concludes that current percentage inflation already exceeds forecast estimates in the absence of a pandemic scenario through an OLS model. Recognizing transmission lags from exogenous variables to the target variable, an ARDL model is employed, which can incorporate differing leads/lags. Both the models predicted a lower inflation rate in the absence of Pandemic and Government Intervention than the actual inflation rate. This was deemed prima facie evidence that inflationary pressure from an increase in Money supply overpowered decreases in employment and money velocity. It was posited that when the economy reopens, this effect may further worsen due to the theoretically direct relationship between velocity, employment, and inflation. The study cautions runaway inflation, akin to Latin America’s failed trials in Modern Monetary Theory type policies and many instances enshrined in history.
Regionally differential water pricing strategy: An example from Karst region of China
Authors: Yang Fan , Riaz Noman , Cheng Jianwei , Wu Guoyong
Published: February 2024

The study objective is to analyze the water expenditure of 4315 rural households in the Karst region of China. The empirical results have been analyzed by using the extended linear expenditure system model. The study has been based on water expenditure, which provides a feasible differential water pricing strategy in the karst region of China. The result shows that (1) the coefficient for water expenditure has been examined as low. The coefficient of water expenditure in the Karst region ranges from 0.534 to 1.025%, the average value is 0.723%, and the modified coefficient ranges from 0.814 to 1.508%, with an average value of 1.070%. (2) The marginal consumption propensity of rural residents in the Karst region is 0.2%, and the marginal consumption propensity in each province ranges from 0.1 to 1%. (3) The per capita basic water demand has 3 m3. In this scenario, the study recommended that basic water prices range from CNY 2.091 to CNY 3.468 per cubic meter. If the water consumption exceeds basic demand (3 m3 per month), then the bearing water price shall not be lower than CNY 2.091 to CNY 3.468 per cubic meter and not higher than CNY 7.122 per cubic meter.
ESTUDOS DO DISCURSO NAS CIÊNCIAS HUMANAS E DA LINGUAGEM:
Authors: Cavalcante Filho Urbano
Published: February 2024

Na contemporaneidade, presenciamos um fenômeno preocupante que está manifesto e materializado na linguagem pelo sujeito da linguagem: trata-se de um forte movimento negacionista, explicitamente marcado por uma postura de oposição à ciência, às evidências científicas, teóricas e metodológicas sobre importantes questões relacionadas à vida do homem em sociedade.
Questões étnico-raciais nas propostas de língua inglesa da Base Nacional Comum Curricular
Authors: De Jesus Junior Joel
Published: February 2024

O presente artigo concentra-se nas propostas de Língua Inglesa da Base Nacional Comum Curricular, a fim de verificar a presença de questões étnico-raciais nas competências e habilidades desse componente curricular e, desta forma, propor reflexões para a formação dos estudantes em agentes críticos e reflexivos a partir dessa temática. A pesquisa utiliza a ferramenta Localizar Texto do software Adobe Reader para buscar as palavras relacionadas a questões étnico-raciais nas competências e habilidades de Língua Inglesa. Os resultados revelam que as questões étnico-raciais são tratadas de maneira neutra, indefinida e restritas a dois anos do Ensino Fundamental. O artigo parte das contribuições de Ribas (2018) sobre a Língua Inglesa na BNCC e apoia-se em Bakhtin (2004), Rajagopalan (2009) e Street (2014) para tratar do ensino de línguas sob a ótica social. Ferraz (2018), Celani (1999), Jordão (2004) norteiam o diálogo sobre a educação linguística em Língua Inglesa. Duboc (2012) e Apple (2002) dão subsídios para a reflexão sobre currículo. Souza Santos (2018), Hooks (2013) e Gomes (2011) amparam a discussão sobre as questões étnico-raciais.
Me dá um like aê: um relato de experiência sobre o papel das eletivas de base no Novo Ensino Médio em São Luís - MA
Authors: FÁBIO PEIXOTO DE ARAUJO ANDRADE DA SILVA MARCELO
Published: February 2024

O ano letivo de 2022 no Brasil tem como premissa ser um ano da voltas às aulas presenciais, por conta da pandemia causada pelo vírus Covid-19. Na Rede Estadual de Educação do Maranhão, as escolas estão a todo vapor em 2022 e com uma novidade: o Novo Ensino Médio (NEM). A Secretaria de Estado da Educação do Estado do Maranhão (SEDUC-MA) trouxe algumas orientações basilares com respeito ao que se espera, em termos de conteúdo, para o atual ano letivo, bem como algumas orientações outras no que diz respeito ao NEM, entre elas, as chamadas “metodologias de êxito”. Neste ínterim, o presente trabalho objetiva realizar um de relato de experiência pautado em uma das metodologias de êxito, conhecida por “eletiva de base”, aplicada em duas turmas 1º ano do ensino médio. A culminância das eletivas apontou para uma adesão de boa parte das turmas em que foi aplicada, revelando um talento natural dos jovens estudantes no que diz respeito à linguagem nas redes sociais.
DISCURSOS AFIRMATIVOS NAS TRAMAS DO SABER-PODER
Authors: Witzel Denise
Published: February 2024

Na continuidade da tarefa de oportunizar o alargamento do espaço de discussão acerca do fenômeno da linguagem, seu funcionamento e suas implicações, na égide da investigação linguística, a Revista Saridh (Linguagem e Discurso) apresenta, nesta edição (volume 5, número 1 - 2023), uma entrevista com a pesquisadora e professora Denise Gabriel Witzel, da Universidade Estadual do Centro Oeste (Unicentro). A participação da Professora Denise é instrumento que não apenas abrilhanta, de forma singular e inédita, a discussão sobre os discursos afirmativos, mas, para além disso, lustram o celebrado momento de fala sobre a problemática da midiatização. Com todo o louvor que lhe é devido e com a perícia que é marca forte de sua forma de ler o mundo e suas manifestações, a Professora Denise mobiliza em suas respostas uma profundeza intelectual típica e que nos apresenta a reflexão sobre as interseccionalidades, as lutas e os engajamentos a que estamos sujeitos e submetidos frente às demandas da sociedade contemporânea.
TRANSGRESSÕES CARNAVALESCAS: UMA ANÁLISE DISCURSIVA DO BLOCO DE CARNAVAL “AS MUQUIRANAS”
Authors: De Lima Luísa Gabrielli , Garcia Dantielli Assumpção Garcia
Published: February 2024

Neste trabalho, buscamos analisar o bloco de Carnaval “As Muquiranas”. As temáticas escolhidas pelo bloco ao longo dos anos podem ter diferentes significados e interpretações, dependendo do contexto cultural, social e histórico em que são apresentadas. Por um lado, essas referências a mulheres icônicas da cultura popular e da história podem ser uma forma de celebrar e homenagear a presença e contribuição das mulheres na sociedade, dando destaque a personagens femininas. Por outro lado, é importante lembrar que as mulheres, muitas vezes, foram historicamente subordinadas e oprimidas, e que essas temáticas podem reforçar imaginários e ideias limitadas sobre o papel das mulheres na sociedade.  Este trabalho está ancorado teórica e metodologicamente na teoria da Análise de Discurso francesa, tendo como principais autores Michel Pêcheux e Eni. P. Orlandi. Observam-se, então, que os atos de violência transcorrem pela ação do homem, este trabalho se justifica pela relevância social de analisar discursivamente a atuação dos participantes heterossexuais do bloco “As Muquiranas”, bem como as violências[1] praticadas contra mulheres, homossexuais e travestis. Portanto, o corpus desta pesquisa consiste em analisar uma seleção de Sequências Discursivas retiradas de postagens do Instagram voltadas ao bloco de carnaval “As Muquiranas”.  

 

[1] Morais, físicas e verbais.
A CONCEPTUALIZAÇÃO DE FAKE NEWS COMO EVIDÊNCIA DA COGNIÇÃO SOCIAL
Authors: Carolina da Cruz Rafaely
Published: February 2024

O presente trabalho se insere na discussão da compreensão da linguagem humana em sua dimensão individual e social, abordando as bases ontológicas e os aspectos biológicos e sociais da cognição. A Linguística Cognitiva, desde seu advento, posiciona a linguagem como intrinsecamente ligada a outros processos sociocognitivos, como a interação e a perspectivação. Morato (2019a) identifica desafios na pesquisa cognitiva, incluindo a superação do naturalismo, a relação entre linguagem e cognição, e a interdisciplinaridade. Michael Tomasello (2003, 2019), destaca-se nesse campo ao explorar a ontogenia da psicologia humana e sua relação com aspectos sociais e culturais. Diante disso, este artigo tem como objetivo mostrar, a partir dos estudos sociocognitivos, a construção do frame de fake news como evidência da cognição social. A pesquisa se concentra em comentários do curso online “Cidadania digital e leitura crítica", disponível no Portal TEC Sala de Aula, oferecido para professores da educação básica entre 2018 e 2021. Estes comentários oferecem uma perspectiva valiosa sobre como a cognição social influencia a compreensão e disseminação do conceito de "fake news", indicando que o entendimento desse fenômeno é influenciado pela cooperação, perspectivação e experiências individuais e sociais.
Internal Carotid Artery Dissecting Aneurysm Associated with Persistent
Trigeminal Artery: A Case Report
Authors: Bu Chunqing , Liu Xiaomin , Zhang Yanfeng , Chen Jun , Wang Jinshen
Published: February 2024

Background::

Persistent trigeminal artery (PTA) is the most common vascular anastomosis between the carotid artery and vertebrobasilar systems. We report a
very rare case of dissecting aneurysm in the right internal carotid artery (ICA) with ipsilateral PTA and discuss its clinical importance.

Case Report::

A 38-year-old male presented to the emergency department with paroxysmal dysphasia for 6h. Brain magnetic resonance (MR) imaging showed
acute cerebral infarction of the right corona radiata and right parietal lobe. Three-dimensional time-of-flight MR angiography (3D TOF MRA)
revealed severe stenosis of the petrous segment (C1 portion) of the right internal carotid artery and a PTA originating from the right ICA cavernous
segment (C4 portion), with a length of approximately 1.8cm and a diameter of approximately 0.2cm. The ICA segments are all named according to
the Bouthilier classification. The basilar artery (BA) under union was well developed. The bilateral posterior communicating arteries were also
present. One day later, the high-resolution vessel-wall MR demonstrated a dissecting aneurysm in the C1 portion of the right ICA. The length of
the dissecting aneurysm is approximately 4.4cm, the diameter of the true lumen at the most severe stenosis is approximately 0.2cm, and the
diameter of the false lumen is approximately 0.8cm. Subsequent digital subtraction angiography (DSA) confirmed a dissecting aneurysm in the C1
portion of the right ICA. The patient was treated conservatively and did not undergo interventional surgery. Four months later, head and neck
MRA showed that the right ICA blood flow was smooth and that the dissecting aneurysm had disappeared.

:

The Ethics Committee of Liaocheng People’s Hospital approved the research protocol in compliance with the Helsinki Declaration. Written
informed consent was obtained from the individual for the publication of any potentially identifiable images or data included in this article.

Conclusion::

Flow alteration with PTA may have influenced the formation of ICA dissection in this patient. Awareness of this is crucial in clinical practice
because it can influence treatment options and intervention procedures.
Remediation using SSCS model for reducing misconceptions about work and energy
Authors: Taqwim M Ahsanul , Sunarno Widha , Ramli Murni
Published: February 2024

Misconceptions are discrepancies between students' understanding of concepts and concepts defined by experts. Misconceptions are indicated as latent dangers in the learning process. One of the topics in science that has a high level of misconception among students is the concept of work and energy. The SSCS model is an approach put forward as an effective way to train students' conceptual understanding. This research aims to determine whether the misconceptions about the work and energy of grade 7 students will be reduced by applying the SSCS model (Search, Solve, Create, and Share) as a remediation approach. The experimental design was applied using a one-group pretest-posttest design. The research sample comprised 32 students (15 boys and 17 girls). Profiling of students' misconceptions before and after the action was measured using 14 two-level multiple-choice questions. There are four types of misconceptions based on initial measurements. The results show an average pretest score of 44.07 and an average posttest of 63.60. It can be concluded that the SSCS model significantly reduces student misconceptions. Further research on the types of errors present in mapping student profiles is recommended.
Development of Augmented Reality (AR) Learning Media to Increase Student Motivation and Learning Outcomes in Science
Authors: Yusa Ilham Widia , Wulandari Ana Yuniasti Retno , Tamam Badrud , Rosidi Irsad , Yasir Mochammad , Setiawan Achmad Yusuf Bagus
Published: February 2024

This research aims to 1) develop AR learning media regarding the interaction of living things and the environment, 2) determine the feasibility and response to AR media, and 3) determine differences in students' motivation and science learning outcomes before and after implementing AR media. AR-based mobile application. The study of AR media development uses the Waterfall development model which consists of 5 stages, namely analysis, design, code, testing, and maintenance. In-depth research data collection techniques use observation sheets, interview guides, media expert and material expert validation questionnaires, student response questionnaires as well as science learning motivation questionnaires and cognitive tests. The learning trial used a quasi-experimental design method with a research pattern using a nonequivalent control group pretest and posttest design involving 2 classes, namely class VII-C as the control group and VII-D as the experimental group. The results of the research show that 1) AR-based mobile applications can be used anytime and anywhere, the resulting applications are equipped with animations, games, and 3-dimensional and 2-dimensional images, 2) the product is valid and AR-based AR-based mobile applications are suiTabel for testing and response results in students towards AR-based mobile applications received a very good response from students, 3) learning using AR-based mobile applications can increase learning motivation and student learning outcomes, especially in the subject of interaction between living things and the environment.
Effects of Mind Mapping And Visual Imagery Instruction Strategies on Senior Secondary Schools Students’ Scientific Attitude to Mechanics in Ekiti State of Nigeria
Authors: Ukoh Edidiong E , ALADEJANA Alaba Lawrence
Published: February 2024

The study examined the effects of visual imagery and mind mapping strategies on physics students’ scientific attitude to mechanics in Ekiti state, Nigeria. The study adopted 3 X 1 pretest-posttest control group quasi experimental research design. Eight senior secondary schools were be purposively selected for the experimental groups, while four schools were purposively selected for the control group. This made a total of twelve schools that were selected from twelve local government areas across all the three senatorial districts of Ekiti state for the study. A total number of two hundred and forty six physics students from the selected schools were used. The instrument that the researcher used for the study was self-designed instruments titled: Students’ Scientific Attitude to Mechanics. The data collected were analysed using descriptive statistics (mean, standard deviation) as well as inferential statistics such as Analysis of Covariate (ANCOVA) which was used to determine the significant mean and interaction effects to the variables of the study. Estimated Marginal Mean (EMM) was used to determine the performance of each group. Bonferroni pair wise and Scheffe Post-hoc analyses were also employed to trace the source of observed significance among the groups. The finding of the study revealed that there was significant effect of treatment on students’ scientific attitude to mechanics. The result further showed that those exposed to visual imagery had the highest scientific attitude mean score, closely followed by those exposed to mind mapping while those taught with conventional method of teaching had the least. Also, the finding of the study showed that there was  significant main effect of gender on students’ scientific attitude to mechanics. Similarly, the finding showed that there was significant interaction effect of treatment and gender on students’ scientific attitude. Based on these findings, it was therefore recommended that mind mapping and visual imagery instructional strategies should be used in improving students’ scientific attitude.
INDICATORS AND DIMENSIONS IN THE FORMULATION AND EVALUATION OF A SUSTAINABLE CAMPUS INDEX
Authors: Abdullah Siti Nor Fazillah , Kamarudin Mohd Khairul Amri , Abd Wahab Noorjima , Yaakub Nadzifah , Sunardi Sunardi
Published: February 2024

The establishment of a green campus assumes significance in ensuring comfort and elevating the overall quality of life. This study was conducted to ascertain the variability in the questionnaires and delineate the attributes of questions exhibiting high variation in the results. Therefore, constructing the UniSZA Green Campus index based on the acquired weighted values. A total of 420 questionnaires were returned out of 500. Principal Component Analysis was employed to extract distinctive information from the amalgamated dataset. The results of the analysis draw out four factors that were discerned and subsequently interpreted as environmental management (46.65%), environmental infrastructure (12.53%), environmental atmosphere (6.35%), and environmental program (5.39%). In assessing the variation of the UniSZA Green Campus Index, distinct categories were identified, encompassing excellent, good, fair, poor, and bad classifications. This study suggests that the average UniSZA Green Campus index is situated within the second category. Despite the indication of good standing, the university should proactively take steps to ensure that UniSZA aligns with the principles of environmental sustainability in daily practices. The index system can serve as a guide for universities to attain sustainability on their campuses.