bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association of Physical (in)Activity with Mental Health. Differences between Elder and Younger Populations: A Systematic Literature Review
Authors: Maynou Laia , Hernández-Pizarro Helena M. , Errea Rodríguez María
Published: April 2021

Background: Physical activity is associated with mental health benefits. This systematic literature review summarises extant evidence regarding this association, and explores differences observed between populations over sixty-five years and those younger than sixty-five. Methods: We reviewed articles and grey literature reporting at least one measure of physical activity and at least one mental disorder, in people of all ages. Results: From the 2263 abstracts screened, we extracted twenty-seven articles and synthesized the evidence regarding the association between physical (in)activity and one or more mental health outcome measures. We confirmed that physical activity is beneficial for mental health. However, the evidence was mostly based on self-reported physical activity and mental health measures. Only one study compared younger and elder populations, finding that increasing the level of physical activity improved mental health for middle aged and elder women (no association was observed for younger women). Studies including only the elderly found a restricted mental health improvement due to physical activity. Conclusions: We found inverse associations between levels of physical activity and mental health problems. However, more evidence regarding the effect of ageing when measuring associations between physical activity and mental health is needed. By doing so, prescription of physical activity could be more accurately targeted.
Prenatal Exposure to Cigarette Smoke and Anogenital Distance at 4 Years in the INMA-Asturias Cohort
Authors: García-Villarino Miguel , Fernández-Iglesias Rocío , Riaño-Galán Isolina , Rodríguez-Dehli Cristina , Babarro Izaro , Fernández-Somoano Ana , Tardón Adonina
Published: April 2021

Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) is a sensitive biomarker of prenatal androgen and antiandrogen exposure. We investigated the effect of smoking and passive smoke exposure during pregnancy on anogenital distance in offspring at 4 years in the INMA-Asturias cohort (Spain). Women were interviewed during pregnancy to collect information on tobacco consumption, and anogenital distance was measured in 381 children: Anoscrotal distance in boys and anofourchetal distance in girls. We also measured maternal urinary cotinine levels at 32 weeks of pregnancy. We constructed linear regression models to analyze the association between prenatal smoke exposure and anogenital distance and adjusted the models by relevant covariates. Reported prenatal smoke exposure was associated with statistically significant increased anogenital index (AGI), both at week 12 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) and at week 32 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) in male children, suggesting altered androgenic signaling.
Source Characterization of Multiple Reactive Species at an Abandoned Mine Site Using a Groundwater Numerical Simulation Model and Optimization Models
Authors: Hayford Michael Saah , Datta Bithin
Published: April 2021

The most important first step in the management and remediation of contaminated groundwater aquifers is unknown contaminant source characterization. Often, the hydrogeological field data available for accurate source characterization are very sparse. In addition, hydrogeological and geochemical parameter estimates and field measurements are uncertain. Particularly in complex contaminated sites such as abandoned mine sites, the geochemical processes are very complex and identifying the sources of contamination in terms of location, magnitude, and duration, and determination of the pathways of pollution become very difficult. The reactive nature of the contaminant species makes the geochemical transport process very difficult to model and predict. Additionally, the source identification inverse problem is often non-unique and ill posed. This study is about developing and demonstrating a source characterization methodology for a complex contaminated aquifer with multiple reactive species. This study presents linked simulation optimization-based methodologies for characterization of unknown groundwater pollution source characteristics, i.e., location, magnitude and duration or timing. Optimization models are solved using an adaptive simulated annealing (ASA) optimization algorithm. The performance of the developed methodology is evaluated for different complex scenarios of groundwater pollution such as distributed mine waste dumps with reactive chemical species. The method is also applied to a real-life contaminated aquifer to demonstrate the potential applicability and optimal characterization results. The illustrative example site is a mine site in Northern Australia that is no longer active.
Identifying Risk Factors for Lower Reproductive Tract Infections among Women Using Reusable Absorbents in Odisha, India
Authors: Das Padmalaya , Lisnek Danielle , Sahoo Krushna Chandra , Sinha Shalini , Mohanty JyotiRanjan , Sahoo Pranati , Bilung Bibiana , Panda Bijaya , Tanton Clare , Torondel Belen
Published: April 2021

A large proportion of women in Odisha, India, use reusable absorbents to manage their menstruation. Yet, the risk factors for lower reproductive tract infections (RTIs) related to menstrual hygiene management (MHM) have not been studied among reusable absorbent users. Women of reproductive age attending one of two hospitals from two different cities in Odisha during two separate study intervals were recruited for the study. Laboratory diagnosis of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) were conducted. A questionnaire was used to collect information on MHM practices, water, sanitation, and socio-demographic factors. Among the 509 women who used reusable absorbents, 71.7% were diagnosed with at least one infection. After adjusting for confounders, women with BV were more likely to identify as being a housewife (aOR: 1.8 (1.1–2.9)). Frequent absorbent changing was protective against BV (aOR: 0.5 (0.3–0.8)), whereas frequent body washing increased the odds of BV (aOR: 1.5 (1.0–2.2)). Women with VVC were more likely to be older (aOR: 1.6 (1.0–2.5)), live below the poverty line (aOR: 1.5 (1.1–2.2)), have a non-private household latrine (aOR: 2.2 (1.3–4.0)), dry their absorbents inside the house (aOR: 3.7 (2.5–4.5)), and store absorbents in the latrine area (aOR: 2.0 (1.3–2.9)). Washing absorbents outside the house was protective against VVC (aOR: 0.7 (0.4–1.0)). This study highlights the importance of improving MHM practices among reusable absorbent users to prevent lower RTIs among women reusing menstrual materials in Odisha.
Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation
Authors: Jiménez-Cebrián Ana María , Becerro-de-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta Elena , de Labra Carmen , Calvo-Lobo César , Palomo-López Patricia , Martínez-Jiménez Eva María , Navarro-Flores Emmanuel
Published: April 2021

Background: Kinesiophobia can be an obstacle to physical and motor activity in patients with Parkinson’s disease (PD). PD affects patients’ independence in carrying out daily activities. It also impacts a patient’s biopsychosocial well-being. The objective of this study was to analyze the levels and scores of kinesiophobia in PD patients and compare them with healthy volunteers. Methods: We deployed a case-control study and recruited 124 subjects (mean age 69.18 ± 9.12). PD patients were recruited from a center of excellence for Parkinson’s disease (cases n = 62). Control subjects were recruited from the same hospital (control n = 62). Kinesiophobia total scores and categories were self-reported using the Spanish version of the Tampa Scale of Kinesiophobia (TSK-11). Results: Differences between cases and control groups were analyzed using the Mann–Whitney U test. Statistically significant differences (p < 0.05) were shown between groups when comparing kinesiophobia categories (or levels) and total scores, revealing higher kinesiophobia symptoms and levels in PD patients. All of the PD patients reported some degree of kinesiophobia (TSK-11 ≥ 18), while the majority of PD patients (77.3%) had kinesiophobia scores rated as moderate to severe (TSK-11 ≥ 25). On the other hand, ~45.1% of controls reported no or slight kinesiophobia and 53.2% reported moderate kinesiophobia. Conclusions: Total kinesiophobia scores were significantly higher in PD patients compared with healthy controls, with moderate to severe kinesiophobia levels prevailing in PD patients. Therefore, individuals living with PD should be evaluated and controlled in order to detect initial kinesiophobia symptoms.
Clinical Spectrum Associated with Wolfram Syndrome Type 1 and Type 2: A Review on Genotype–Phenotype Correlations
Authors: Delvecchio Maurizio , Iacoviello Matteo , Pantaleo Antonino , Resta Nicoletta
Published: April 2021

Wolfram syndrome is a rare neurodegenerative disorder that is typically characterized by diabetes mellitus and optic atrophy. Other common features are diabetes insipidus and hearing loss, but additional less-frequent findings may also be present. The phenotype spectrum is quite wide, and penetrance may be incomplete. The syndrome is progressive, and thus, the clinical picture may change during follow-up. Currently, two different subtypes of this syndrome have been described, and they are associated with two different disease-genes, wolframin (WFS1) and CISD2. These genes encode a transmembrane protein and an endoplasmic reticulum intermembrane protein, respectively. These genes are detected in different organs and account for the pleiotropic features of this syndrome. In this review, we describe the phenotypes of both syndromes and discuss the most pertinent literature about the genotype–phenotype correlation. The clinical presentation of Wolfram syndrome type 1 suggests that the pathogenic variant does not predict the phenotype. There are few papers on Wolfram syndrome type 2 and, thus, predicting the phenotype on the basis of genotype is not yet supported. We also discuss the most pertinent approach to gene analysis.
Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI
Authors: Shen Chao-Yu , Weng Jun-Cheng , Tsai Jeng-Dau , Su Pen-Hua , Chou Ming-Chih , Wang Shu-Li
Published: April 2021

Previous studies have indicated that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse neuropsychiatric disorders in children and adolescents. This study aimed to determine the association between the concentrations of prenatal EDCs and brain structure changes in teenagers by using MRI. We recruited 49 mother–child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs—including phthalate esters, perfluorochemicals (PFCs), and heavy metals (lead, arsenic, cadmium, and mercury)—in maternal urine and/or serum. MRI voxel-based morphometry (VBM) and generalized q-sampling imaging (GQI) mapping—including generalized fractional anisotropy (GFA), normalized quantitative anisotropy (NQA), and the isotropic value of the orientation distribution function (ISO)—were obtained in teenagers 13–16 years of age in order to find the association between maternal EDC concentrations and possible brain structure alterations in the teenagers’ brains. We found that there are several specific vulnerable brain areas/structures associated with prenatal exposure to EDCs, including decreased focal brain volume, primarily in the frontal lobe; high frontoparietal lobe, temporooccipital lobe and cerebellum; and white matter structural alterations, which showed a negative association with GFA/NQA and a positive association with ISO, primarily in the corpus callosum, external and internal capsules, corona radiata, superior fronto-occipital fasciculus, and superior longitudinal fasciculus. Prenatal exposure to EDCs may be associated with specific brain structure alterations in teenagers.
Social Inequities in Urban Heat and Greenspace: Analyzing Climate Justice in Delhi, India
Authors: Mitchell Bruce C. , Chakraborty Jayajit , Basu Pratyusha
Published: April 2021

Climate change and rapid urbanization currently pose major challenges for equitable development in megacities of the Global South, such as Delhi, India. This study considers how urban social inequities are distributed in terms of burdens and benefits by quantifying exposure through an urban heat risk index (UHRI), and proximity to greenspace through the normalized difference vegetation index (NDVI), at the ward level in Delhi. Landsat derived remote sensing imagery for May and September 2011 is used in a sensitivity analysis of varying seasonal exposure. Multivariable models based on generalized estimating equations (GEEs) reveal significant statistical associations (p < 0.05) between UHRI/NDVI and several indicators of social vulnerability. For example, the proportions of children (β = 0.922, p = 0.024) and agricultural workers (β = 0.394, p = 0.016) are positively associated with the May UHRI, while the proportions of households with assets (β = −1.978, p = 0.017) and households with electricity (β = −0.605, p = 0.010) are negatively associated with the May UHRI. In contrast, the proportions of children (β = 0.001, p = 0.633) and agricultural workers (β = 0.002, p = 0.356) are not significantly associated with the May NDVI, while the proportions of households with assets (β = 0.013, p = 0.010) and those with electricity (β = 0.008, p = 0.006) are positively associated with the May NDVI. Our findings emphasize the need for future research and policies to consider how socially vulnerable groups are inequitably exposed to the impact of climate change-related urban heat without the mitigating effects of greenspace.
A Comparative Assessment of Cooling Center Preparedness across Twenty-Five U.S. Cities
Authors: Kim Kyusik , Jung Jihoon , Schollaert Claire , Spector June T.
Published: April 2021

Cooling centers have played a significant role in reducing the risks of adverse health impacts of extreme heat exposure. However, there have been no comparative studies investigating cooling center preparedness in terms of population coverage, location efficiency, and population coverage disparities among different subpopulation groups. Using a catchment area method with a 0.8 km walking distance, we compared three aspects of cooling center preparedness across twenty-five cities in the U.S. We first calculated the percentage of the population covered by a single cooling center for each city. Then, the extracted values were separately compared to the city’s heat indexes, latitudes, and spatial patterns of cooling centers. Finally, we investigated population coverage disparities among multiple demographics (age, race/ethnicity) and socioeconomic (insurance, poverty) subpopulation groups by comparing the percentage of population coverage between selected subpopulation groups and reference subpopulation groups. Our results showed that cooler cities, higher latitude cities, and cities with dispersed cooling centers tend to be more prepared than warmer cities, lower latitude cities, and cities with clustered cooling centers across the U.S. Moreover, older people (≥65) had 9% lower population coverage than younger people (≤64). Our results suggest that the placement of future cooling centers should consider both the location of other nearby cooling centers and the spatial distribution of subpopulations to maximize population coverage and reduce access disparities among several subpopulations.
Preference towards HIV Self-Testing above Other Testing Options in a Sample of Men Who Have Sex with Men from Five European Countries
Authors: Hoyos Juan , Maté Tomás , Guerras Juan-Miguel , Donat Marta , Agustí Cristina , Kuske Matthias , Fuertes Ricardo , Chanos Sophocles , Pichon Francois , Sordo Luis , Pulido José , Belza María-José ,   on behalf of the EURO HIV EDAT Group
Published: April 2021

We analyzed men who have sex with men (MSM) from Denmark, Germany, Greece, Portugal and Spain to identify who would choose HIV self-testing as their preferred testing method and assessed their preferred setting to acquire a self-testing kit and to confirm a reactive result. In 2016, we recruited an online sample of 3725 HIV-negative MSM. We used Poisson regression to identify factors associated with choosing self-testing as the preferred testing option. For those choosing it as their preferred option, we assessed the preferred settings to acquire a self-testing kit and to confirm a reactive result. Not being open about one’s sexual behaviors with men was associated with choosing self-testing as the preferred option, except in Greece; older age in Greece and Spain; reporting condomless anal intercourses (CAI) in Germany and Portugal; reporting one previous test in Greece; between 2 and 5 in Spain and with having been tested ≥ 12 months ago in Germany, Portugal and Spain. The internet (32.8%) was the preferred place to acquire a self-testing kit and primary care (34.0%) for confirmation purposes. Self-testing was highly valued, especially among individuals who were not open about their sexual behaviors with men. In certain countries, it was also associated with older age, CAI and being undertested.
Refugee Women with a History of Trauma: Gender Vulnerability in Relation to Post-Traumatic Stress Disorder
Authors: Vallejo-Martín Macarena , Sánchez Sancha Ana , Canto Jesús M.
Published: April 2021

Refugees represent a population whose living conditions have a strong impact on their mental health. High rates of post-traumatic stress disorder (PTSD), more than other mental disorders, have been found in this group, with women having the highest incidence. The objective of the present systematic review was to identify and examine studies from the last fifteen years on the relationship between the impact of traumatic experiences and PTSD psychopathology in refugee women. Twelve studies were included, from which the overall results approved this relation. In addition, six of these studies show that exposure to sexual trauma in refugee women is associated with the high odds of being at risk for PTSD. These findings suggest that gender-related traumatic experiences can explain the high rate of PTSD in refugee women and highlight the unmet need for psychosocial health care in this population.
Survey on Public Psychological Intervention Demand and Influence Factors Analysis
Authors: Su Fang , Fan Bingjie , Song Nini , Dong Xue , Wang Yanxia , Li Jingzhong , Xue Bing , Qiao Xianrong
Published: April 2021

Major public health emergencies would have a negative influence on the psychology of the public, and an effective psychological intervention can help them to relieve some emotions, such as tension and panic. However, differences in individual environments affect people’s psychological intervention demands and intervention mode choices. Therefore, it is of great theoretical and practical value to analyze and identify the key factors affecting these demands and choices. Based on a nationwide sample of 24,188 respondents from the “Internet Survey of Residents’ Behavioral Changes and Psychological Conditions during the Epidemic”, the different characteristics of public psychological intervention demands and choices under different factors are explored in this paper. The results demonstrate that: (1) the psychological status of Chinese people was relatively stable during the epidemic period, and there were 1016 respondents who had subjective demands for a psychological intervention, (2) age, gender, occupation type, residence, family size, risk perception, psychological status, education level, and fixed expenditure all significantly affect public psychological intervention demands, and (3) risk perception, psychological status, age, gender, and family size will impact the choice of psychological intervention methods. The above results can provide a decision-making basis for the construction of a psychological intervention system in psychological crisis management during the post-epidemic prevention and control period, as well as reference and suggestions for handling psychological stress of similar sudden crisis events in the future.
Particulate Matter 10 (PM10) Is Associated with Epistaxis in Children and Adults
Authors: Kim Kyungsoo , Kwak Il-Youp , Min Hyunjin
Published: April 2021

The impact of atmospheric concentration of particulate matter ≤10 μm in diameter (PM10) continues to attract research attention. This study aimed to evaluate the effects of meteorological factors, including PM10 concentration, on epistaxis presentation in children and adults. We reviewed the data from 1557 days and 2273 cases of epistaxis between January 2015 and December 2019. Eligible patients were stratified by age into the children (age ≤17 years) and adult groups. The main outcome was the incidence and cumulative number of epistaxis presentations in hospital per day and month. Meteorological factors and PM10 concentration data were obtained from the Korea Meteorological Administration. Several meteorological factors were associated with epistaxis presentation in hospital; however, these associations differed between children and adults. Only PM10 concentration was consistently associated with daily epistaxis presentation in hospital among both children and adults. Additionally, PM10 concentration was associated with the daily cumulative number of epistaxis presentations in hospital in children and adults. Furthermore, the monthly mean PM10 concentration was significantly associated with the total number of epistaxis presentations in the corresponding month. PM10 concentration should be regarded as an important environmental factor that may affect epistaxis in both children and adults.
An Analysis of the Trend of Fetal Mortality Rates among Working and Jobless Households in Japan, 1995–2019
Authors: Okui Tasuku
Published: April 2021

This study aimed to identify differences in the trends of artificial and spontaneous fetal mortality rates between working and jobless households depending on ages, periods, and birth cohorts in Japan. Vital Statistics data from 1995 to 2019 and age groups in 5–year increments from 15 to 19 years through 45 to 49 years were used. Bayesian age–period–cohort analysis was used to evaluate changes in each of the outcomes. As a result, the difference in maternal age–standardized rate of both the artificial and spontaneous fetal mortality rates between the two types of households decreased in the periods analyzed. However, there was a statistically significant difference in the mortality rate between jobless and working households, regardless of maternal ages, periods, and cohorts for the artificial fetal mortality rate. A statistically significant difference was also observed for the spontaneous fetal mortality rates in some maternal ages, periods, and cohorts. In addition, the trend of birth cohort effects was particularly different between the two types of households for both the artificial and spontaneous fetal mortality rates.
Travel Website Atmospheres Inducing Older Travelers’ Familiarity: The Moderating Role of Cognitive Age
Authors: Kim Soojung , Bi Yahua , Kim Insin
Published: April 2021

In the environment in which an increasing number of older travelers are participating in online tourism platforms, for older travelers who face multiple barriers in using e-commerce, it is essential to identify factors promoting older travelers’ website usage for their well-being and sustainable travel industry. This study aims to identify the key factors of website atmosphere for enhancing older travelers’ familiarity, investigate the relationship between older adults’ website familiarity and revisit intention, and test the moderating role of cognitive age. A web-based survey was conducted, and the sample consisted of 305 US residents 50 years of age and older who had experienced travel websites. The results indicated that three subdimensions of older travelers’ website familiarity—informativeness, effectiveness, and entertainment—positively influence their website familiarity. Additionally, the impact of informativeness on website familiarity is stronger for travelers who identify as younger than their chronological age. Moreover, older travelers’ familiarity with a website improves their revisit intention. The current study found not only significant travel website atmosphere factors to boost older travelers’ participation in online tourism platforms but also significant older travelers’ groups depending on their cognitive age perception to magnify the effect of website atmosphere.
Introduction to the Special Issue on Cascading Disaster Modelling and Prevention
Authors: Huggins Thomas J. , Yang Lili , Sornette Didier
Published: April 2021

The 2019 Global Assessment Report (GAR2019) on Disaster Risk Reduction [...]
The Knowledge, Attitude and Practice about Public Emergencies and the Response Capability of Residents in Shanghai after the Outbreak of Coronavirus Disease 2019 (COVID-19): A Cross-Sectional Study
Authors: Lu Jingting , Guo Xiaoqin , Han Xiaoyu , Deng Biao , Zhao Qi , Zhao Genming , He Na
Published: April 2021

People’s knowledge, attitude and practice (KAP) are a part of the public’s emergency response capability and play an important role in controlling public health emergencies. This study aims to evaluate Shanghai residents’ KAP and the response ability regarding public health emergency events in China. An anonymous questionnaire investigation including demographics, socioeconomic characteristics and KAP was conducted through the online survey system from April 19 to April 30 2020. Of the 1243 people who completed the questionnaire, 1122 respondents (90.3%) had a good, positive attitude, while only 46.8% of participants had good knowledge, 46.2% performed well in the aspect of practice and 19.5% of residents had good response capability. It was found that men (OR:1.57,95% CI: 1.16–2.13), and people with 10 to 12 years or longer than 12 years of education (OR: 2.08,95% CI: 1.14–3.92; OR: 3.56,95% CI: 1.96–6.72) had the best public emergency response capability. Positive attitudes may be significantly associated with good practice (OR: 1.76, 95% CI: 1.18–2.64). Internet and television were the major media for people to acquire knowledge and skills. A lack of knowledge, poor perception and poor emergency response ability were found in Shanghai residents. Target intervention should be developed and implemented to improve the knowledge and skills of people for dealing with public emergency events.
Parental Behavioral Control and Bullying and Victimization of Rural Adolescents in China: The Roles of Deviant Peer Affiliation and Gender
Authors: Chen Xu , Li Ling , Lv Gangwu , Li Hui
Published: April 2021

Bullying and victimization (BAV) have been widely studied, but the potential mechanism of parental behavioral control (PBC) on bullying and victimization in Chinese adolescents has not been explored. This study aimed to examine a moderated mediation model for the association between PBC and BAV mediated by deviant peer affiliation (DPA) and moderated by gender. A total of 3779 adolescents (Nboy = 1679, Mage = 14.98 years, SD = 0.95) from southwest China has completed the Peer Bullying, Peer Victimization, PBC, and DPA questionnaires. The results indicated that: (1) PBC significantly predicted adolescents’ BAV (−12%); (2) DPA mediated the effect of PBC on BAV only for those adolescents who were both bullies and victims; (3) the mediating role of DPA was moderated by gender only in the relationship between PBC and victimization, with a relatively stronger effect in girls than in boys.
Correlation between Handgrip Strength and Depression in Older Adults—A Systematic Review and a Meta-Analysis
Authors: Zasadzka Ewa , Pieczyńska Anna , Trzmiel Tomasz , Kleka Paweł , Pawlaczyk Mariola
Published: April 2021

Background: Depression remains an important health problem among older adults and it may be correlated with the deterioration of physical fitness, whose chief indicator is hand grip strength (HGS). The aim of the study was to investigate the relationship between depression and HGS among older populations using the available literature. Methods: PubMed, Web of Science and Science Direct databases were searched. The inclusion criteria were as follows: written in English and published after 2009, subject age: ≥60 years, HGS measured using a hand dynamometer, assessment of the depressive symptoms using a validated tool. The following articles were excluded: studies conducted among institutionalized subjects and/or populations with a specific disease. Results: The total combined effect of 33 results presented in 16 studies included in the meta-analysis, converted to the correlation coefficient, was OEr = −0.148 (SE = 0.030, 95%CI: −0.206–−0.091), indicating a weak, negative correlation between HGS and depressive symptoms. Conclusions: The review of the literature and the meta-analysis demonstrated a relationship between low muscle strength and intensified depressive symptoms in older populations. Bearing in mind that depression is often unrecognized or underdiagnosed among older patients, lowered muscle strength should be an important sign for physicians and an incentive to screen them for depression.
Further Exploration of the Psychometric Properties of GamTest: A Rasch Analysis
Authors: Forsström David , Rozental Alexander , Kottorp Anders , Lindner Philip , Jansson-Fröjmark Markus , Hesser Hugo
Published: April 2021

GamTest is a self-rating scale of negative consequences of gambling, included in the popular responsible gambling tool Playscan as part of an overall risk assessment and feedback feature. Two previous psychometric evaluations of this instrument yielded contradictory results: in an online high-gambling population, a five-factor model was supported and the instrument had overall good psychometric properties, but in a low-gambling population, the same factor structure was not supported. Because GamTest is used with both low- and high-gambling populations, more psychometric research is needed to fully understand how the instrument works. The current study examined, for the first time, psychometric performance among a sample of low-gambling respondents using a Rasch analysis. Results indicated that the instrument could be improved by decreasing the scale-steps and removing several problematic items demonstrating misfit. Furthermore, the findings indicated that some items functioned differently depending on gender, and that a shortened, improved nine-item version could not differentiate between different levels of risk. Our findings suggest that the instrument would arguably benefit from being adapted for use in a low-gambling population.
Effects of the Menstrual Cycle on Jumping, Sprinting and Force-Velocity Profiling in Resistance-Trained Women: A Preliminary Study
Authors: García-Pinillos Felipe , Bujalance-Moreno Pascual , Lago-Fuentes Carlos , Ruiz-Alias Santiago A. , Domínguez-Azpíroz Irma , Mecías-Calvo Marcos , Ramirez-Campillo Rodrigo
Published: April 2021

The aim of this study was to examine the effects of the menstrual cycle on vertical jumping, sprint performance and force-velocity profiling in resistance-trained women. A group of resistance-trained eumenorrheic women (n = 9) were tested in three phases over the menstrual cycle: bleeding phase, follicular phase, and luteal phase (i.e., days 1–3, 7–10, and 19–21 of the cycle, respectively). Each testing phase consisted of a battery of jumping tests (i.e., squat jump [SJ], countermovement jump [CMJ], drop jump from a 30 cm box [DJ30], and the reactive strength index) and 30 m sprint running test. Two different applications for smartphone (My Jump 2 and My Sprint) were used to record the jumping and sprinting trials, respectively, at high speed (240 fps). The repeated measures ANOVA reported no significant differences (p ≥ 0.05, ES < 0.25) in CMJ, DJ30, reactive strength index and sprint times between the different phases of the menstrual cycle. A greater SJ height performance was observed during the follicular phase compared to the bleeding phase (p = 0.033, ES = −0.22). No differences (p ≥ 0.05, ES < 0.45) were found in the CMJ and sprint force-velocity profile over the different phases of the menstrual cycle. Vertical jump, sprint performance and the force-velocity profiling remain constant in trained women, regardless of the phase of the menstrual cycle.
Physical Activity and Perceived Physical Fitness during the COVID-19 Epidemic: A Population of 40- to 69-Year-Olds in Japan
Authors: Makizako Hyuma , Akaida Shoma , Shono Saki , Shiiba Ryuhei , Taniguchi Yoshiaki , Shiratsuchi Daijo , Nakai Yuki
Published: April 2021

The COVID-19 pandemic has caused an abrupt change in lifestyle for many people with restrictions, often leading to a decrease in physical activity (PA), and thus contributing to a negative perception of health status. The purpose of this study was to examine the effects of the COVID-19 epidemic on physical activity and perceived physical fitness in Japanese adults aged 40 to 69 years. Data were collected from an online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1989 Japanese adults (mean age, 50.1 ± 6.9 years; women, 38.9%) who were aged between 40 and 69 years and completed the online survey. Overall, the PA time per week decreased by 32.4% between October 2019 and April 2020. A decrease in PA time was recorded in October 2020; however, a decline of 15.5% was observed. Compared to individuals who did not perceive a decline in physical fitness, individuals who perceived declining physical fitness during the COVID-19 state of emergency demonstrated a greater decrease in PA time in April 2020 (–50.5%), and this trend continued into October 2020 (–25.0%). These findings may indicate that Japanese adults aged 40 to 69 years who perceived declining physical fitness experienced a greater decrease in physical activity.
Comparative Analysis of the Effectiveness of Performing Advanced Resuscitation Procedures Undertaken by Two- and Three- Person Basic Medical Rescue Teams in Adults under Simulated Conditions
Authors: Krzyżanowski Kamil , Ślęzak Daniel , Dąbrowski Sebastian , Żuratyński Przemysław , Mędrzycka-Dąbrowska Wioletta , Buca Paulina , Jastrzębski Paweł , Robakowska Marlena
Published: April 2021

(1) Objective: Paramedics as a profession are a pillar of the State Medical Rescue system. The basic difference between a specialist and a basic team is the composition of members. The aim of the study was to benchmark the effectiveness of performing advanced resuscitation procedures undertaken by two- and three-person basic emergency medical teams in adults under simulated conditions. (2) Design: The research was observational. 200 two- and three-people basic emergency medical teams were analyzed during advanced resuscitation procedures, ALS (Advanced Life Support) in adults under simulated conditions. (3) Method: The study was carried out among professionally active and certified paramedics. It lasted over two years. The study took place under simulated conditions using prepared scenarios. (4) Results: In total, 463 people took part in the study. The analysis of the survey results indicates that the efficiency of three-person teams is superior to the activities performed by two-person teams. Three-person teams were quicker to perform rescue actions than two-person teams. The two-person teams were much quicker to assess the condition of victims than the three-person teams. The three-person teams were more likely to check an open airway. The three-person teams were more efficient in assessing the heart rhythm and current condition of victims. It was demonstrated that three-person teams were more effective during electrotherapy. The analysis demonstrated that three-person teams were significantly faster and more efficient in chest compressions. Three-person teams were less likely to use emergency airway techniques than two-person teams. The results indicate that three-person teams administered the first dose of adrenaline significantly faster than two-person teams. For the “call for help”, the three-person teams were found to be more effective. (5) Conclusion: Paramedics in three-person teams work more effectively, make a proper assessment of heart rhythm and monitor when taking advanced actions. The quality of ventilation and BLS in both groups studied is insufficient. Numerous errors have been observed in two-person teams during pharmacotherapy.
Categorizing IQOS-Related Twitter Discussions
Authors: Barker Joshua O. , Vassey Julia , Chen-Sankey Julia C. , Allem Jon-Patrick , Cruz Tess Boley , Unger Jennifer B.
Published: April 2021

(1) Background: The heated tobacco product IQOS, by Philip Morris International, is now available in over 55 countries, including the United States. Social media sites such as Twitter are often used to promote or discuss tobacco products, though prior research has not examined how IQOS is presented on Twitter. (2) Methods: This study collected and categorized Twitter conversations involving IQOS. A manual content analysis was performed on N = 3916 English tweets related to IQOS published internationally between 1 January 2020 and 30 June 2020. (3) Results: Most tweets were either online marketing for IQOS (32.3%) or personal testimonials related to IQOS use (34.2%). Personal testimonial tweets made harm reduction claims about IQOS either as an avenue to quit smoking/tobacco use (3.4%), or in comparison to combustible cigarettes (2.0%). Tobacco policy-related tweets were detected (13.9%), split between discussions of United States (4.9%) and international (4.4%) policies. News media tweets (14.2%) were also detected. (4) Conclusions: Our study suggests IQOS may be understood as a less harmful alternative to vaping and combustible cigarettes. Discussions also suggest IQOS is likely to be used to avoid clean air policies or used in areas in which smoking is restricted.
Beyond the Pale: Dark Traits and Close Relations Influence Attitudes toward COVID-19 and the Rejection of Quarantine Rules
Authors: Espinosa Pablo , Clemente Miguel
Published: April 2021

Dark personality traits are predictors of detrimental behavior (e.g., selfishness or violating norms). This research examined the influence dark personality traits on attitudes toward the COVID-19 pandemic and quarantine rules. We determined whether specific dark traits could predict non-compliance, beyond the global measure of dark personality traits. Additionally, previous research suggests that people are more likely to violate rules for the benefits of close relations, rather than for their own self-interests. We examined how this tendency interacts with dark traits. The 823 participants in the study completed measures of the dark triad, moral disengagement, and attitudes toward COVID-19 rules, and responded to vignettes about themselves or close relations escaping quarantine. Using a bifactor model approach, results showed that a general dark factor predicted non-compliance to COVID-19 rules, but that some moral disengagement mechanisms contributed to non-compliance beyond this factor. Vignette results showed that participants were more willing to break quarantine rules for a close relation than for themselves, except for those high in moral disengagement, who broke rules more—regardless of who was involved. These findings have important implications for intervention programs and policies, since individuals with dark traits tend to “selfishly” trespass norms, but anyone can “go beyond the pale, i.e., go outside the limits of acceptable behavior, for a loved one.
An Exploratory Study of the Association between Housing Price Trends and Antidepressant Use in Taiwan: A 10-Year Population-Based Study
Authors: Lee Chen-Yin , Chen Pao-Huan , Lin Yen-Kuang
Published: April 2021

This study examined the relationship between various economic indexes and incidences of antidepressant prescriptions during 2001–2011 using the National Health Insurance Research Database (NHIRD). As of 2007, approximately 98.4% of Taiwanese people were enrolled in the NHIRD. In total, 531,281 records identified as antidepressant prescriptions were collected. Furthermore, 2556 quarterly observations from the Taiwan Housing Index (THI) and Executive Yuan were retrieved. We examined the association between the housing index and antidepressant prescription incidence. During the 10-year follow-up period, a higher incidence of antidepressant prescriptions was associated with the local maximum housing index. The relative risk of being prescribed antidepressant increased by 13.3% (95% confidence interval (CI): 1.01~1.27) when the THI reached a peak. For the low-income subgroup, the relative risk of being prescribed antidepressants increased by 28% during the high season of the THI. We also stratified the study sample on the basis of their sex, age, and urbanization levels. Both sexes followed similar patterns. During 2001–2011, although rising economic indexes may have increased incomes and stimulated the housing market, the compromise of public mental health could be a cost people have to pay additional attention to.
Rapid Screening of Glucocorticoid Receptor (GR) Effectors Using Cortisol-Detecting Sensor Cells
Authors: Ryu Jeahee , Lee Euiyeon , Kang Chungwon , Lee Minhyeong , Kim Soyoun , Park Seungil , Lee Daeyeon , Kwon Youngeun
Published: April 2021

Cortisol, a stress hormone, plays key roles in mediating stress and anti-inflammatory responses. As abnormal cortisol levels can induce various adverse effects, screening cortisol and cortisol analogues is important for monitoring stress levels and for identifying drug candidates. A novel cell-based sensing system was adopted for rapid screening of cortisol and its functional analogues under complex cellular regulation. We used glucocorticoid receptor (GR) fused to a split intein which reconstituted with the counterpart to trigger conditional protein splicing (CPS) in the presence of targets. CPS generates functional signal peptides which promptly translocate the fluorescent cargo. The sensor cells exhibited exceptional performance in discriminating between the functional and structural analogues of cortisol with improved sensitivity. Essential oil extracts with stress relief activity were screened using the sensor cells to identify GR effectors. The sensor cells responded to peppermint oil, and L-limonene and L-menthol were identified as potential GR effectors from the major components of peppermint oil. Further analysis indicated L-limonene as a selective GR agonist (SEGRA) which is a potential anti-inflammatory agent as it attenuates proinflammatory responses without causing notable adverse effects of GR agonists.
Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects
Authors: Banerjee Kaushita , Madhyastha Radha , Nakajima Yuichi , Maruyama Masugi , Madhyastha Harishkumar
Published: April 2021

Dermal wound healing describes the progressive repair and recalcitrant mechanism of 12 damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Bioengineered alternative agents will likely continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new products continue to cut costs and improve the wound healing process. This review article provides an update on the various remedies with confirmed wound healing activities of metal-based nanoceutical adjuvanted agents and also other nano-based counterparts from previous experiments conducted by various researchers.
Fructose Intake Impairs the Synergistic Vasomotor Manifestation of Nitric Oxide and Hydrogen Sulfide in Rat Aorta
Authors: Berenyiova Andrea , Golas Samuel , Drobna Magdalena , Cebova Martina , Cacanyiova Sona
Published: April 2021

In this study, we evaluated the effect of eight weeks of administration of 10% fructose solution to adult Wistar Kyoto (WKY) rats on systolic blood pressure (SBP), plasma and biometric parameters, vasoactive properties of the thoracic aorta (TA), NO synthase (NOS) activity, and the expression of enzymes producing NO and H2S. Eight weeks of fructose administration did not affect SBP, glycaemia, or the plasma levels of total cholesterol or low-density and high-density lipoprotein; however, it significantly increased the plasma levels of γ-glutamyl transferase and alanine transaminase. Chronic fructose intake deteriorated endothelium-dependent vasorelaxation (EDVR) and increased the sensitivity of adrenergic receptors to noradrenaline. Acute NOS inhibition evoked a reduction in EDVR that was similar between groups; however, it increased adrenergic contraction more in fructose-fed rats. CSE inhibition decreased EDVR in WKY but not in fructose-fed rats. The application of a H2S scavenger evoked a reduction in the EDVR in WKY rats and normalized the sensitivity of adrenergic receptors in rats treated with fructose. Fructose intake did not change NOS activity but reduced the expression of eNOS and CBS in the TA and CSE and CBS in the left ventricle. Based on our results, we could assume that the impaired vascular function induced by increased fructose intake was probably not directly associated with a decreased production of NO, but rather with impairment of the NO–H2S interaction and its manifestation in vasoactive responses.
Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1
Authors: Monoe Yuya , Jingushi Kentaro , Kawase Akitaka , Hirono Takayuki , Hirose Ryo , Nakatsuji Yoshino , Kitae Kaori , Ueda Yuko , Hase Hiroaki , Abe Yuichi , Adachi Jun , Tomonaga Takeshi , Tsujikawa Kazutake
Published: April 2021

Previously, we have revealed that the miR-130 family (miR-130b, miR-301a, and miR-301b) functions as an oncomiR in bladder cancer. The pharmacological inhibition of the miR-130 family molecules by the seed-targeting strategy with an 8-mer tiny locked nucleic acid (LNA) inhibits the growth, migration, and invasion of bladder cancer cells by repressing stress fiber formation. Here, we searched for a functionally advanced target sequence with LNA for the miR-130 family with low cytotoxicity and found LNA #9 (A(L)^i^i^A(L)^T(L)^T(L)^G(L)^5(L)^A(L)^5(L)^T(L)^G) as a candidate LNA. LNA #9 inhibited cell growth in vitro and in an in vivo orthotopic bladder cancer model. Proteome-wide tyrosine phosphorylation analysis suggested that the miR-130 family upregulates a wide range of receptor tyrosine kinases (RTKs) signaling via the expression of phosphorylated Src (pSrcTyr416). SILAC-based proteome analysis and a luciferase assay identified protein tyrosine phosphatase non-receptor type 1 (PTPN1), which is implicated as a negative regulator of multiple signaling pathways downstream of RTKs as a target gene of the miR-130 family. The miR-130-targeted LNA increased and decreased PTPN1 and pSrcTyr416 expressions, respectively. PTPN1 knockdown led to increased tumor properties (cell growth, invasion, and migration) and increased pSrcTyr416 expression in bladder cancer cells, suggesting that the miR-130 family upregulates multiple RTK signaling by targeting PTPN1 and subsequent Src activation in bladder cancer. Thus, our newly designed miR-130 family targeting LNA could be a promising nucleic acid therapeutic agent for bladder cancer.