bluuebunny/crossref_metadata_2025 huggingface dataset:
Cadmium in Selected Organs of Game Animals from Areas with Different Degrees of Industrialisation and Its Intake by Human Consumers
Authors: Bąkowska Małgorzata , Pilarczyk Bogumiła , Tomza-Marciniak Agnieszka , Pilarczyk Renata , Udała Jan
Published: January 2024

The aim of this study was to determine the concentration of cadmium (Cd) in the organs of game animals from areas with different degrees of industrialisation and to assess its intake following the consumption of the livers of these animals. The material for this study consisted of liver and kidney samples taken from roe deer (Capreolus capreolus), red deer (Cervus elaphus), and wild boar (Sus scrofa) from five regions differing in land use and industrialisation. Compared to the kidneys, the liver was an indicator of the current state of the environment and Cd intake, while the kidney was used to assess the long-term accumulation of Cd in the body. The cadmium concentration in the samples was determined by inductively coupled plasma atomic emission spectrometry. The cadmium concentrations of the organs were found to vary according to geographical location, with the highest levels being observed in Southern Poland, i.e., areas characterised by the highest degree of industrialisation and the presence of heavy industry. However, high Cd concentrations were also reported in the northeastern region. Examples of excessive cadmium levels in the kidneys were noted in all tested regions. Cd intake by humans was evaluated by calculating the estimated daily cadmium intake, and this was compared with the tolerable weekly intake (TWI). The TWI was only exceeded by children frequently consuming wild boar liver from the southwest region.
Species Differences and Tissue Distribution of Heavy Metal Residues in Wild Birds
Authors: Khwankitrittikul Patamawadee , Poapolathep Amnart , Poapolathep Saranya , Prasanwong Chayanid , Kulprasertsri Sittinee , Khidkhan Kraisiri
Published: January 2024

Birds are useful as bioindicators of metal pollution, but the variety of species and tissue distribution may influence the study of heavy metal burdens in birds. The objective of this study was to determine the levels of heavy metals in wild birds’ carcasses to acquire information on species differences and the tissue distribution of metals in wild birds in Thailand. Species differences in metal buildup were observed in the livers and kidneys, but not in the feathers. A significantly higher accumulation of Cd was found in the livers and kidneys of the granivorous birds compared to those in the water birds. In all the groups of birds, the Pb level in the livers (>15 ppm) and feathers (>4 ppm) exceeded the threshold limits, causing potential lead poisoning and disturbing the reproductive success. The Cd accumulation in the kidneys was above 2–8 ppm, indicating increased environmental exposure to Cd in these birds. The Cd, Pb, Ni, Zn, and Fe concentrations in the livers could be estimated using the kidneys, while the Pb level in the liver may be predicted using feathers. Furthermore, water birds’ feathers may be potentially appropriate bioindicators for long-term exposure. Research on the origin of metal contamination is needed to reduce the threat of heavy metals to the health of both birds and other wildlife species.
Privacy Protection Based on Special Identifiers of Intersection Base Computing Technology
Authors: Zhang Ping , Ma Tengfei , Zhang Qing , Zhang Ji , Wang Jiechang
Published: January 2024

Private Set Intersection Cardinality (PSI-CA) and Private Set Union Cardinality (PSU-CA) are two cryptographic primitives whereby two or more parties are able to obtain the cardinalities of the intersection and the union of their respective private sets, and the privacy of their sets is preserved. In this paper, we propose a new privacy protection intersection cardinality protocol, which can quickly deal with set inequality and asymmetry problems and can obtain 100% correct results, and, in terms of efficiency, we are much faster than using the polynomial method. Our protocol adopts the Paillier addition homomorphic encryption scheme and applies the identifier guidance technology, using identifier determination, to the semi-homomorphic encryption ciphertext environment, excluding a large number of different options and quickly finding the base of the intersection of two sides.
The Effect of Incorporating Juncus Fibers on the Properties of Compressed Earth Blocks Stabilized with Portland Cement
Authors: Sadouri Reda , Kebir Hocine , Benyoucef Mustafa
Published: January 2024

This study investigates the impact of incorporating Juncus fibers (JF) into compressed earth blocks (CEBs) stabilized with varying Portland cement contents, aiming to enhance local construction materials’ performance and reduce housing costs. CEB composites were produced with soil stabilized using different cement contents (4%, 8%, and 12% by weight) and JF reinforcement (0 to 0.2% by weight), compressed at 10 MPa with a hydraulic press. After 28 days of drying, the CEBs underwent diverse experimental characterizations to assess their physical, mechanical, thermal, and durability properties. The results revealed that incorporating JF led to a reduction in unit weight, ultrasonic pulse velocity (up to 36%), and dry compressive strength (approximately 17%). Higher fiber content correlated with increased water absorption and an increased capillarity coefficient. Thermal conductivity analysis indicated improved thermal performance, decreasing from 0.4350 W/m·K (12% cement without fibers) to 0.2465 W/m·K (4% cement with 0.2% JF). Despite the decrease in mechanical strength, CEBs with lower cement (4%) and higher fiber content (0.2%) demonstrated satisfactory durability (abrasion and erosion) and thermal insulation properties. This research suggests the potential of this material as a promising composite for the building materials industry. The findings contribute valuable insights into sustainable construction materials and have implications for cost-effective housing solutions.
Optimization of the Control Algorithm for an Active Bearing Support
Authors: Turek Paweł
Published: January 2024

This article presents a spindle system with an active bearing support for which the author proposed a control system based on a PID controller. This type of solution improves the mechanical properties of this spindle by changing the stiffness, which results in a wider range of permissible rotational speeds, lower power losses and an increased resistance to vibrations of the entire system. This work describes the mechanism of changing the bearing preload. During tests on a real test stand, the correct functioning of the preload control system was checked for various dynamic conditions. In this work, the author describes the controller used to work in a feedback system, explains how the settings for this controller were selected and their optimization. The assessment of the correct operation of the controller is based on minimizing the amplitude of forced vibrations for the front spindle end by actively controlling the preload of the bearings. This publication is intended to present one of the ways to solve the important problem of limiting the maximum values of the vibration amplitude in the spindle system for its wide range of operating conditions. It also shows how important its optimal settings are in control systems.
Ultra-High-Performance Concrete (UHPC) Piles and Splicing Options
Authors: Odelola Michael , Dolati Seyed Saman Khedmatgozar , Mehrabi Armin , Garber David
Published: January 2024

Conventional driven piles are made from steel, concrete, timber, or composite materials. These piling options have limitations with respect to corrosion, durability, driveablity, and performance. Ultra-High-Performance Concrete (UHPC) pile is a new alternative that has already been adopted by various state Departments of Transportation in the United States for addressing the limitations that exist with conventional piles. UHPC piles are made of a cementitious composite material mixture that possesses exceptional properties such as higher strength, low capillary porosity, and high resistance to corrosion, making them a suitable option for use as a deep foundation. For several reasons, it is necessary to cast piles with a shorter length and splice them at the site to reach the desired lengths. These reasons include shipping limitations, unpredictable soil condition, reducing transportation costs, construction time, and damage during installation. This study aims to explore and summarize the currently available options for connecting UHPC pile segments. Accordingly, after a brief introduction on driven piles, this paper investigates various splicing systems that can be used for UHPC piles through reviewing previous research studies and field applications. The applicable splices are then compared based on several criteria such as capacity, durability, cost, and ease of application.
Examining and Comparing the Effectiveness of Virtual Reality Serious Games and LEGO Serious Play for Learning Scrum
Authors: Gordillo Aldo , López-Fernández Daniel , Mayor Jesús
Published: January 2024

Significant research work has been undertaken related to the game-based learning approach over the last years. However, a closer look at this work reveals that further research is needed to examine some types of game-based learning approaches such as virtual reality serious games and LEGO Serious Play. This article examines and compares the effectiveness for learning Scrum and related agile practices of a serious game based on virtual reality and a learning activity based on the LEGO Serious Play methodology. The presented study used a quasi-experimental design with two groups, pre- and post-tests, and a perceptions questionnaire. The sample was composed of 59 software engineering students, 22 of which belonged to group A, while the other 37 were part of group B. The students in group A played the virtual reality serious game, whereas the students in group B conducted the LEGO Serious Play activity. The results show that both game-based learning approaches were effective for learning Scrum and related agile practices in terms of learning performance and motivation, but they also show that the students who played the virtual reality serious game outperformed their peers from the other group in terms of learning performance.
Review on Modeling and SOC/SOH Estimation of Batteries for Automotive Applications
Authors: Dini Pierpaolo , Colicelli Antonio , Saponara Sergio
Published: January 2024

Lithium-ion batteries have revolutionized the portable and stationary energy industry and are finding widespread application in sectors such as automotive, consumer electronics, renewable energy, and many others. However, their efficiency and longevity are closely tied to accurately measuring their SOC and state of health (SOH). The need for precise algorithms to estimate SOC and SOH has become increasingly critical in light of the widespread adoption of lithium-ion batteries in industrial and automotive applications. While the benefits of lithium-ion batteries are undeniable, the challenges related to their efficient and safe management cannot be overlooked. Accurate estimation of SOC and SOH is crucial for ensuring optimal battery management, maximizing battery lifespan, optimizing performance, and preventing sudden failures. Consequently, research and development of reliable algorithms for estimating SOC and SOH have become an area of growing interest for the scientific and industrial community. This review article aims to provide an in-depth analysis of the state-of-the-art in SOC and SOH estimation algorithms for lithium-ion batteries. The most recent and promising theoretical and practical techniques used to address the challenges of accurate SOC and SOH estimation will be examined and evaluated. Additionally, critical evaluation of different approaches will be highlighted: emphasizing the advantages, limitations, and potential areas for improvement. The goal is to provide a clear view of the current landscape and to identify possible future directions for research and development in this crucial field for technological innovation.
Comparison between Peritumoral and Intratumoral Budding in Colorectal Cancer
Authors: Pyo Jung-Soo , Choi Ji Eun , Kim Nae Yu , Min Kyueng-Whan , Kang Dong-Wook
Published: January 2024

Tumor budding (TB) is classified, based on location, into peritumoral budding (PTB) or intratumoral budding (ITB). This study aimed to evaluate the relationship between PTB and ITB in colorectal cancers (CRCs). PTB and ITB were investigated and subsequently divided into high and low groups. CRCs were divided into three groups: (1) high PTB/ITB, (2) high PTB or ITB, and (3) low PTB/ITB. The clinicopathological and prognostic significances were evaluated according to the three tumor budding (TB) groups. High PTB/ITB and low PTB/ITB were identified in 32 (12.0%) and 135 (50.8%) patients, respectively. A total of 99 patients (37.2%) were found to have high PTB or ITB. TB was significantly correlated with lymphatic and perineural invasion, lymph node metastasis, metastatic lymph node ratio, distant metastasis, and a higher pTNM stage. A significant correlation was found between high PTB and high ITB (p = 0.010). The amount of PTB was found to increase significantly with the amount of ITB (p < 0.001) in a linear regression test. Patients with high PTB/ITB had worse overall and recurrence-free survival than those with high PTB or ITB. Conversely, patients with low PTB/ITB had better overall and recurrence-free survival rates than those with high PTB or ITB. However, there was no significant difference in overall and recurrence-free survival between patients with high PTB/low ITB and high ITB/low PTB (p = 0.336 and p = 0.623, respectively). In summary, the presence of TB, regardless of PTB or ITB, was significantly correlated with aggressive tumor behavior and a worse prognosis than the absence of TB. Additionally, the present study demonstrated that it is feasible to stratify the prognosis of patients based on whether they have both PTB and ITB or only one of the two.
Using the Grey Wolf Aquila Synergistic Algorithm for Design Problems in Structural Engineering
Authors: Varshney Megha , Kumar Pravesh , Ali Musrrat , Gulzar Yonis
Published: January 2024

The Aquila Optimizer (AO) is a metaheuristic algorithm that is inspired by the hunting behavior of the Aquila bird. The AO approach has been proven to perform effectively on a range of benchmark optimization issues. However, the AO algorithm may suffer from limited exploration ability in specific situations. To increase the exploration ability of the AO algorithm, this work offers a hybrid approach that employs the alpha position of the Grey Wolf Optimizer (GWO) to drive the search process of the AO algorithm. At the same time, we applied the quasi-opposition-based learning (QOBL) strategy in each phase of the Aquila Optimizer algorithm. This strategy develops quasi-oppositional solutions to current solutions. The quasi-oppositional solutions are then utilized to direct the search phase of the AO algorithm. The GWO method is also notable for its resistance to noise. This means that it can perform effectively even when the objective function is noisy. The AO algorithm, on the other hand, may be sensitive to noise. By integrating the GWO approach into the AO algorithm, we can strengthen its robustness to noise, and hence, improve its performance in real-world issues. In order to evaluate the effectiveness of the technique, the algorithm was benchmarked on 23 well-known test functions and CEC2017 test functions and compared with other popular metaheuristic algorithms. The findings demonstrate that our proposed method has excellent efficacy. Finally, it was applied to five practical engineering issues, and the results showed that the technique is suitable for tough problems with uncertain search spaces.
An All-in-One Platform for On-Site Multiplex Foodborne Pathogen Detection Based on Channel-Digital Hybrid Microfluidics
Authors: Xie Mei , Chen Tianlan , Cai Zongwei , Lei Bo , Dong Cheng
Published: January 2024

Recently, significant progress has been made in the development of microdevices for point-of-care infectious disease detection. However, most microdevices only allow limited steps, such as DNA amplification on the chip, while sample preparation, such as lysis and DNA extraction, is conducted off the chip using the traditional method. In this study, an all-in-one platform was developed, which incorporated all necessary procedures for nucleic acid detection. Our on-chip DNA extraction method utilized the magnetic bead-based technology on a hybrid channel-digital microfluidics (C-DMF) microdevice. It yielded high recovery rates, varying from 88.43% to 95.83%, with pathogen concentrations of 103–106 CFU/mL. In particular, the on-chip method exhibited significantly higher efficacy compared to the traditional off-chip manual method, for the DNA extraction of E. coli and S. aureus, representing Gram-negative and Gram-positive bacteria, respectively, at a sample concentration of 103 CFU/mL. To address the need for rapid and accessible diagnostics, colorimetric LAMP amplification was integrated into the proposed microdevice. The results were visually detectable with the naked eye, making it user-friendly for non-specialists. In addition, this platform demonstrated impressive sensitivity in simultaneously detecting common foodborne pathogens in spiked meat samples, achieving the LOD of 102–103 CFU/mL. The entire process, from sampling to result, was fully automated and only required approximately 60 min, offering promising applicability in resource-limited and on-site testing scenarios.
Quantum Computing and the Future of Neurodegeneration and Mental Health Research
Authors: Stefano George B.
Published: January 2024

Quantum computing and supercomputing are two distinct approaches that can be used to solve complex computational problems [...]
Modeling the Environmental Impact of Passenger Cars Driven on Hilly Roads in Austria: A More Accurate Valuation of Greenhouse Gas Emissions and Further Environmental Indicators for Integral Life Cycle Assessments of Road Infrastructures
Authors: Hausberger Lukas , Lutterbach Jounes , Gschösser Florian
Published: January 2024

Previous studies of road or railway infrastructures have shown that traffic emissions outweigh the environmental impacts of the product stage and construction stage over the entire life cycle. Traffic usage is therefore the main emitter over the life cycle (A1–C4). Due to the small number of sustainability assessment systems, the question of how to consider traffic emissions in detail in an integral life cycle assessment has arisen. This study examines Austrian car traffic and investigates environmental impacts beyond the scope of carbon dioxide and particulate matter. The results were determined for a selection of common impact indicators. In addition to driving in flat terrain, an approach is presented that enables the evaluation of emissions due uphill and downhill driving. Thus, route options and route closures/detours due to maintenance work can be evaluated in a simple way. During the analyses, a traffic calculator was developed, which can currently assess different cars depending on the route specifics (flat/hill). The tool can be expanded to include other road vehicles (buses, trucks, motorcycles) and trains as well. This will simplify evaluations and decision-making processes and provide optimal support for a future-proof sustainable built environment.
The Effects of Economic Sector GDP on Low-Income Housing Supply, Colombia’s Regions Case
Authors: Urazán-Bonells Carlos Felipe , Rondón-Quintana Hugo Alexander , Caicedo-Londoño María Alejandra
Published: January 2024

The regions with the best economy have a greater capacity to develop low-income or social-impact housing, thus contributing to the reduction of poverty and, therefore, to the fulfillment of Sustainable Development Goals. This is observed in fewer people living in extreme poverty and with fewer unmet basic needs. This present article analyzes the correlation between the development in the main economic sectors in different regions (departments) of Colombia and the supply of low-income housing. Nevertheless, the most remarkable relation that was found was between the economic development of the regions (GDP) and the supply of non-social housing (more expensive commercial value) (Spearman’s Rho: 0.9). This means that there is an imbalance between regional economic capacity and the low-income housing supply because the regions with higher economic potential should have a less demanding population, that is, people living in poverty. These correlations are better when they go hand in hand with activities that are mostly developed in an urban environment, such as manufacturing, construction, real estate, and finance and insurance. On the contrary, these correlations are worse with industries such as mining and agriculture that mostly operate in rural areas. The analysis between low-income housing and economic sectors’ GDP yields low correlations, but these are worse for rural industries. Also, the investigation shows a positive change in the correlations’ trend for the year 2021, the beginning of the post-pandemic economic recovery.
Surface Redox Reaction for the Synthesis of NiPt Catalysts for the Upgrading of Renewable Ethanol/Methanol Mixtures
Authors: Pasel Joachim , Woltmann Friederike , Häusler Johannes , Peters Ralf
Published: January 2024

Mixtures of ethanol and methanol being synthesized from CO2 and green H2 can serve as sustainable base chemicals for a number of chemical processes. Amongst these processes, the catalytically supported synthesis of CO2-neutral C4 to C10 alcohols is of increasing importance as, e.g., iso-butanol can be used as a drop-in fuel or after dehydration to produce iso-butene as a feedstock for the synthesis of plastics. 2-ethyl-hexanol can be further refined into solvents, tensides, or monomers. In this respect, NiPt alloys on an activated carbon support were found to be active and stable catalysts for the synthesis of iso-butanol following the Guerbet reaction scheme. In this study, two different routes are applied to the synthesis of these NiPt catalysts: a more conventional one based on the impregnation of Ni and Pt salts and an advanced path with a surface redox reaction between elemental Ni on the support and Pt ions in a polar solution. The experimental evaluation shows that the Pt particles from the surface redox reaction being exposed on the Ni particles are more active than those on the impregnated catalysts due to their high surface energy. Their specific space-time yields are 10–20 times higher.
Insights into the Mechanism, Regio-/Diastereoselectivities and Ligand Role of Nickel-Initiated [3+2] Cycloadditions between Vinylcyclopropane and N-Tosylbenzaldimine
Authors: Mu Weihua , Zhu Lin , Xia Shuya , Tan Xue , Duan Liangfei , Meng Guanghao , Liu Guo
Published: January 2024

Density functional theory (DFT) was employed to explore the reaction mechanism, regio- and diastereoselectivities of nickel-initiated [3+2] cycloaddition between vinylcyclopropane (VCP) and N-tosylbenzaldimine assisted by phosphine ligands. Four different binding modes of the nickel center to VCP substrate were explored during the ring-opening of VCP, among which the C,C_anti and C,C_syn modes were verified to be the most accessible ones. Further explorations about four different phosphine ligand-assisted reactions based on the two most probable binding modes show that the difference in binding mode of bi- and monodentate phosphine ligands can vary the optimal reaction pathway, especially in the [3+2] cycloaddition process between the ring-opened intermediate and N-tosylbenzaldimine. The formation of C–C and C–N bonds between N-tosylbenzaldimine and the ring-opened intermediate through [3+2] cycloaddition is found to be stepwise, with the former acting as the rate-determining step (RDS) in most cases. Computed free energy barriers of RDS transition states on the optimal path I or II not only give out good predictions for reaction rates and half-lives, but also provide reasonable explanations for the major generation of cis-pyrrolidine. Noncovalent interaction analyses of key stationary points suggest the rate is influenced by both electronic effects and steric hindrance, while the diastereoselectivity is mainly controlled by electronic effects.
An Analysis of Fixed-Bed Catalytic Reactors Performances for One-Stage Butadiene Synthesis from Ethanol
Authors: Brosteanu Alma Valentina , Banu Ionut , Bozga Grigore
Published: January 2024

The present study assesses, using a theoretical approach, the performances of two widely used fixed-bed reactors for the ethanol-to-butadiene (ETB) one-stage (Lebedev) process: multibed adiabatic reactors (MBAR) with inter-bed heating and a multitubular reactor (MTR). The mathematical model consists of mass and heat conservation equations at catalyst particle and particle bed scales, coupled with a published kinetic model specific for a modified MgO–SiO2 catalyst. The process simulations at the level of catalyst particle have shown that the inter-phase concentration and temperature gradients are negligible, the only physical step with a limiting influence on process kinetics being the internal diffusion. A simplified version of the reactor model was also formulated, including empirical expressions developed in the study for the calculation of internal effectiveness factors. The reactor simulations highlighted that the MBAR with inter-bed heating by injection of hot reactants provides worse butadiene (BD) yields as a consequence of reduced reaction times (due to reactant by-pass of catalyst beds). The MBAR with inter-bed heating using heat exchangers provides better performances but inferior to those of MTR if the number of catalyst beds is less than six. A preliminary optimization study for the MBAR and MTR is also presented. The results showed that the maximization of BD yield has the drawback of a low BD production rate, whereas the maximization of BD production rate corresponds to a relatively low BD yield and high ethanol and inert recycles. A trade-off between the two extreme cases can be attained by maximizing the income generated by reactor operation.
Differentiation States of Phenotypic Transition of Melanoma Cells Are Revealed by 3D Cell Cultures
Authors: Fontana Fabrizio , Sommariva Michele , Anselmi Martina , Bianchi Francesca , Limonta Patrizia , Gagliano Nicoletta
Published: January 2024

Melanoma is characterized by high metastatic potential favored by the epithelial-to-mesenchymal transition (EMT), leading melanoma cells to exhibit a spectrum of typical EMT markers. This study aimed to analyze the expression of EMT markers in A375 and BLM melanoma cell lines cultured in 2D monolayers and 3D spheroids using morphological and molecular methods. The expression of EMT markers was strongly affected by 3D arrangement and revealed a hybrid phenotype for the two cell lines. Indeed, although E-cadherin was almost undetectable in both A375 and BLM cells, cortical actin was detected in A375 2D monolayers and 3D spheroids and was strongly expressed in BLM 3D spheroids. The mesenchymal marker N-cadherin was significantly up-regulated in A375 3D spheroids while undetectable in BLM cells, but vimentin was similarly expressed in both cell lines at the gene and protein levels. This pattern suggests that A375 cells exhibit a more undifferentiated/mesenchymal phenotype, while BLM cells have more melanocytic/differentiated characteristics. Accordingly, the Zeb1 and 2, Slug, Snail and Twist gene expression analyses showed that they were differentially expressed in 2D monolayers compared to 3D spheroids, supporting this view. Furthermore, A375 cells are characterized by a greater invasive potential, strongly influenced by 3D arrangement, compared to the BLM cell line, as evaluated by SDS-zymography and TIMPs gene expression analysis. Finally, TGF-β1, a master controller of EMT, and lysyl oxidase (LOX), involved in melanoma progression, were strongly up-regulated by 3D arrangement in the metastatic BLM cells alone, likely playing a role in the metastatic phases of melanoma progression. Overall, these findings suggest that A375 and BLM cells possess a hybrid/intermediate phenotype in relation to the expression of EMT markers. The former is characterized by a more mesenchymal/undifferentiated phenotype, while the latter shows a more melanocytic/differentiated phenotype. Our results contribute to the characterization of the role of EMT in melanoma cells and confirm that a 3D cell culture model could provide deeper insight into our understanding of the biology of melanoma.
Association of Functional Gastrointestinal Disorders with Adolescent Idiopathic Scoliosis
Authors: Lee Soo-Bin , Chae Hyun-Wook , Kwon Ji-Won , Sung Sahyun , Moon Seong-Hwan , Suk Kyung-Soo , Kim Hak-Sun , Park Si-Young , Lee Byung Ho
Published: January 2024

Numerous adolescents diagnosed with adolescent idiopathic scoliosis (AIS) often manifest symptoms indicative of functional gastrointestinal disorders (FGIDs). However, the precise connection between FGIDs and AIS remains unclear. The study involved adolescents drawn from sample datasets provided by the Korean Health Insurance Review and Assessment Service spanning from 2012 to 2016, with a median dataset size of 1,446,632 patients. The AIS group consisted of individuals aged 10 to 19 with diagnostic codes for AIS, while the control group consisted of those without AIS diagnostic codes. The median prevalence of FGIDs in adolescents with AIS from 2012 to 2016 was 24%. When accounting for confounding factors, the analysis revealed that adolescents with AIS were consistently more prone to experiencing FGIDs each year (2012: adjusted odds ratio (aOR), 1.21 [95% confidence interval (CI), 1.10–1.35], p < 0.001; 2013: aOR, 1.31 [95% CI, 1.18–1.46], p < 0.001; 2014: aOR, 1.24 [95% CI, 1.12–1.38], p < 0.001; 2015: aOR, 1.34 [95% CI, 1.21–1.49], p < 0.001; and 2016: aOR, 1.35 [95% CI, 1.21–1.50], p < 0.001). These findings suggest that AIS is correlated with an elevated likelihood of FGIDs, indicating that AIS may function as a potential risk factor for these gastrointestinal issues. Consequently, it is recommended to provide counseling to adolescents with AIS, alerting them to the heightened probability of experiencing chronic gastrointestinal symptoms.
Microstructure and Properties of FeAlC-x(WC-Co) Composite Coating Prepared through Plasma Transfer Arc Cladding
Authors: Chen Baiyang , Zhang Bo , Zhao Daming , Gao Peihu , Naumov Anton , Li Qibao , Li Fei , Yang Zhong , Guo Yongchun , Li Jianping , Wu Baolong , Gong Jinyuan , Liu Jiawei
Published: January 2024

Tungsten carbide (WC) is widely used in wear-resistant parts due to its excellent wear resistance. Iron-based alloys are used in the repair and remanufacturing of engine components due to their good compatibility with iron-based workpieces. In order to enhance the wear resistance of engine components in service under abrasive conditions, composite coatings have been prepared for cast iron engine components by adding WC-Co to iron-based powders. This study investigates the microstructure and wear properties of composite coatings of iron-based alloys reinforced with different contents of WC particles. The composite coatings mainly contained γ-Fe, α-Fe, WC and Fe3W3C. With the addition of the WC-Co strengthening phase, the average hardness of the FeAlC-x(WC-Co) composite coatings increases from 524 HV0.2 to 814 HV0.2. Wear test results showed that when the WC addition was 20%, it had the lowest frictional coefficient of 0.5 and the lowest wear mass loss of 1.3 mg. Compared to the original Fe-based alloy coatings, the WC particle-reinforced FeAlC composite coatings display improved wear resistance on a reduced friction basis, mainly benefiting from the high wear resistance of the graphite solid lubrication phase and carbides in the cladding.
Enhancing Collaborative Learning and E-Mentoring in a Smart Education System in Higher Education
Authors: Nguyen Loan , Tomy Sarath , Pardede Eric
Published: January 2024

The requirement to develop a smart education system is critical in the era of ubiquitous technology. In the smart education environment, intelligent pedagogies are constructed to take advantage of technological devices and foster learners’ competencies which undoubtedly assist learners in dealing with knowledge and handling issues in a dynamic society more effectively and productively. This research suggests two effective learning strategies: (1) collaborative learning, which helps learners improve their knowledge and skills by exchanging resources and experiences, and (2) e-mentoring, which connects learners to a wide range of professional communities. This research first proposes a model to show how these two learning methods help learners achieve their goals, along with a set of hypotheses that are explained in detail. Then, a smart education system is proposed which comprises the two learning strategies with the necessary features. Lastly, two questionnaires, one for facilitators and the other for learners, are used to evaluate the usefulness and the feasibility of the proposed model in a real-world educational environment. The great majority of respondents agreed with all the statements, demonstrating the efficiency of the research for educators and learners.
Detection of Pneumothorax in Severe Acute Respiratory Distress Syndrome—Lung Ultrasound Pitfalls
Authors: Mendrala Konrad , Kosiński Sylweriusz , Czober Tomasz , Podsiadło Paweł , Skoczyński Szymon , Darocha Tomasz
Published: January 2024

Lung ultrasound is gaining popularity as a quick, easy, and accurate method for the detection of pneumothorax. The typical sonographic features of pneumothorax are the absence of lung sliding, the presence of a lung point, the absence of a lung pulse, and the absence of B-lines. However, we found that in some cases, each of these elements might be misleading.
Frailty and Survivability of Polish Caucasian Nonagenarians and Centenarians
Authors: Skubiszewska Agnieszka , Broczek Katarzyna , Maruniak-Chudek Iwona , Oledzka Gabriela , Jonas Marta Izabela , Puzianowska-Kuznicka Monika , Mossakowska Malgorzata
Published: January 2024

Frailty is a major geriatric problem leading to an increased risk of disability and death. Prevention, identification, and treatment of frailty are important challenges in gerontology and public health. The study aimed to estimate the prevalence of the frailty phenotype (FP) among the oldest-old Polish Caucasians and investigate the relationship between the FP and mortality. Baseline data were collected from 289 long-lived individuals, including 87 centenarians and 202 subjects aged 94–99. Mortality was obtained from population registers over the following 5 years. Sixty percent of subjects were classified as frail, 33% as prefrail, and 7% as robust. Frailty was more common in women than men and among centenarians than nonagenarians. During the 5-year observation period, 92.6% of the frail women and all frail men died, while mortality rates were lower among prefrail, 78.8% and 66.7%, and robust individuals, 60% and 54.5%, respectively. In the survival analysis, frailty was the strongest negative risk factor: HR = 0.328 (95% CI: 0.200–0.539). The inability to perform handgrip strength measurement was an additional predictor of short survival. In conclusion, the FP is prevalent in nonagenarians and centenarians and correlates with lower survivability. Future studies should address differences between unavoidable age-associated frailty and reversible disability in long-lived individuals.
Health Promotion with Long-Term Physical Activity Program for Adults with Autism Spectrum Disorder
Authors: Dunsky Ayelet , Barak Sharon
Published: January 2024

Individuals with autism spectrum disorder (ASD) are at higher risk for developing common chronic diseases. Engagement in physical activity (PA) can prevent health issues; however, people with ASD are known to engage in lower levels of PA in comparison to their peers. This study evaluated the effect of a long-term, 12-month PA intervention on the fitness and quality of life of adults with ASD. A quantitative approach was implemented to assess participants’ fitness, functional ability, quality of life, and participation in a range of PA classes at three different time points. Qualitative data were collected via in-depth, semi-structured interviews with three participants with ASD and three staff members. A total of 34 adults with ASD (mean age 39.76 + 7.27) participated in the quantitative part of the study. Approximately 53% of the participants exhibited perseverance and conducted adequate PA each month. Significant improvements were found in one fitness component and two quality-of-life components. Factors revealed for the program’s success were the individuals’ free choice of the PA classes and supporting people and a budget that tailored the project. Policymakers who plan health promotion programs for adults with ASD should consider long-term PA programs, with freedom of choice among PA modalities and schedules.
Integrated Generative Adversarial Networks and Deep Convolutional Neural Networks for Image Data Classification: A Case Study for COVID-19
Authors: Khalif Ku Muhammad Naim Ku , Chaw Seng Woo , Gegov Alexander , Bakar Ahmad Syafadhli Abu , Shahrul Nur Adibah
Published: January 2024

Convolutional Neural Networks (CNNs) have garnered significant utilisation within automated image classification systems. CNNs possess the ability to leverage the spatial and temporal correlations inherent in a dataset. This study delves into the use of cutting-edge deep learning for precise image data classification, focusing on overcoming the difficulties brought on by the COVID-19 pandemic. In order to improve the accuracy and robustness of COVID-19 image classification, the study introduces a novel methodology that combines the strength of Deep Convolutional Neural Networks (DCNNs) and Generative Adversarial Networks (GANs). This proposed study helps to mitigate the lack of labelled coronavirus (COVID-19) images, which has been a standard limitation in related research, and improves the model’s ability to distinguish between COVID-19-related patterns and healthy lung images. The study uses a thorough case study and uses a sizable dataset of chest X-ray images covering COVID-19 cases, other respiratory conditions, and healthy lung conditions. The integrated model outperforms conventional DCNN-based techniques in terms of classification accuracy after being trained on this dataset. To address the issues of an unbalanced dataset, GAN will produce synthetic pictures and extract deep features from every image. A thorough understanding of the model’s performance in real-world scenarios is also provided by the study’s meticulous evaluation of the model’s performance using a variety of metrics, including accuracy, precision, recall, and F1-score.
Sepsis Stewardship: The Puzzle of Antibiotic Therapy in the Context of Individualization of Decision Making
Authors: Ramasco Fernando , Méndez Rosa , Suarez de la Rica Alejandro , González de Castro Rafael , Maseda Emilio
Published: January 2024

The main recent change observed in the field of critical patient infection has been universal awareness of the need to make better use of antimicrobials, especially for the most serious cases, beyond the application of simple and effective formulas or rigid protocols. The increase in resistant microorganisms, the quantitative increase in major surgeries and interventional procedures in the highest risk patients, and the appearance of a significant number of new antibiotics in recent years (some very specifically directed against certain mechanisms of resistance and others with a broader spectrum of applications) have led us to shift our questions from “what to deal with” to “how to treat”. There has been controversy about how best to approach antibiotic treatment of complex cases of sepsis. The individualized and adjusted dosage, the moment of its administration, the objective, and the selection of the regimen are pointed out as factors of special relevance in a critically ill patient where the frequency of resistant microorganisms, especially among the Enterobacterales group, and the emergence of multiple and diverse antibiotic treatment alternatives have made the appropriate choice of antibiotic treatment more complex, requiring a constant updating of knowledge and the creation of multidisciplinary teams to confront new infections that are difficult to treat. In this article, we have reviewed the phenomenon of the emergence of resistance to antibacterials and we have tried to share some of the ideas, such as stewardship, sparing carbapenems, and organizational, microbiological, pharmacological, and knowledge tools, that we have considered most useful and effective for individualized decision making that takes into account the current context of multidrug resistance. The greatest challenge, therefore, of decision making in this context lies in determining an effective, optimal, and balanced empirical antibiotic treatment.
Study on Peeling Performance of T-Type Brazing Joints Based on Energy Method
Authors: Duan Peng-Yang , Zhou Guo-Yan , Tu Shan-Tung
Published: January 2024

Brazing technology is widely used in modern industrial systems as an important connection method. The brazing joints are the weakest zone in the whole structure and directly determine the working efficiency and life of the entire system. However, the research on the connection mechanism and fracture behavior of brazing joints is still unclear. In this study, the peeling force and displacement curves during the peeling process are tested by using T-type specimens. Based on the cohesive zone model, the peeling energy of each part during the whole peeling process is calculated and analyzed. The results show that the whole peeling process can be divided into three stages, including the initial stage, crack propagation stage, and stable peeling stage. The peeling energy of each stage can be calculated experimentally. The larger the peeling energy, the better the joint performance. Then, a simplified calculation method for peeling energy is developed for T-type joints and is verified as accurate using experimental data. It is also observed that the increase in the base material thickness can effectively improve the peeling performance of the joints. This provides a feasible and effective method for peel strength calculation and evaluation in brazing joints.
Ceftazidime–Avibactam Improves Outcomes in High-Risk Neutropenic Patients with Klebsiella pneumoniae Carbapenemase-Producing Enterobacterales Bacteremia
Authors: Herrera Fabián , Torres Diego , Laborde Ana , Jordán Rosana , Mañez Noelia , Berruezo Lorena , Lambert Sandra , Suchowiercha Nadia , Costantini Patricia , Nenna Andrea , Pereyra María Laura , Benso José , González Ibañez María Luz , Eusebio María José , Barcán Laura , Baldoni Nadia , Tula Lucas , Roccia Rossi Inés , Luck Martín , Soto Vanesa , Fernández Verónica , Carena Alberto Ángel
Published: January 2024

Few studies have evaluated the efficacy of ceftazidime–avibactam (CA) for Klebsiella pneumoniae carbapenemase-producing Enterobacterales bacteremia (KPC-PEB) in high-risk neutropenic patients. This is a prospective multicenter observational study in high-risk neutropenic patients with multi-drug resistant Enterobacterales bacteremia. They were compared according to the resistance mechanism and definitive treatment provided: KPC-CPE treated with CA (G1), KPC-CPE treated with other antibiotics (G2), and patients with ESBL-producing Enterobacterales bacteremia who received appropriate definitive therapy (G3). Thirty-day mortality was evaluated using a logistic regression model, and survival was analyzed with Kaplan–Meier curves. A total of 238 patients were included: 18 (G1), 52 (G2), and 168 (G3). Klebsiella spp. (60.9%) and Escherichia coli (26.4%) were the Enterobacterales most frequently isolated, and 71% of the bacteremias had a clinical source. The resistance profile between G1 and G2 was colistin 35.3% vs. 36.5%, amikacin 16.7% vs. 40.4%, and tigeclycline 11.1% vs. 19.2%. The antibiotics prescribed in combination with G2 were carbapenems, colistin, amikacin, fosfomycin, tigecycline, and fluoroquinolones. Seven-day clinical response in G1 vs. G2 vs. G3 was 94.4% vs. 42.3% vs. 82.7%, respectively (p < 0.001). Thirty-day overall mortality in G1 vs. G2 vs. G3 was 22.2% vs. 53.8% vs. 11.9%, respectively (p < 0.001), and infection-related mortality was 5.5% vs. 51.9% vs. 7.7% (p < 0.001). The independent risk factors for mortality were Pitt score > 4: OR 3.63, 95% CI, 1.18–11.14 (p = 0.025) and KPC-PEB treated with other antibiotics: OR 8.85, 95% CI, 2.58–30.33 (p = 0.001), while 7-day clinical response was a protective factor for survival: OR 0.02, 95% CI, 0.01–0.08 (p < 0.001). High-risk neutropenic patients with KPC-CPE treated with CA had an outcome similar to those treated for ESBL-producing Enterobacterales, with higher 7-day clinical response and lower overall and infection-related mortality than those treated with other antibiotics. In view of these data, CA may be considered the preferred therapeutic option for KPC-PEB in high-risk neutropenic patients.
Pharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll α Derivative
Authors: Sokol Maria B. , Beganovskaya Veronika A. , Mollaeva Mariia R. , Yabbarov Nikita G. , Chirkina Margarita V. , Belykh Dmitry V. , Startseva Olga M. , Egorov Anton E. , Kostyukov Alexey A. , Kuzmin Vladimir A. , Lomakin Sergei M. , Shilkina Natalia G. , Krivandin Alexey V. , Shatalova Olga V. , Gradova Margarita A. , Abakumov Maxim A. , Nikitin Aleksey A. , Maksimova Varvara P. , Kirsanov Kirill I. , Nikolskaya Elena D.
Published: January 2024

In this study, we described physico-chemical properties of novel nanoformulation of photosensitizer-pyropheophorbide α 17-diethylene glycol ester (XL) (chlorophyll α derivative), revealing insights into antitumor activity and maintaining quality, meeting the pharmaceutical approach of new nanoformulation design. Our formulation, based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles, increased XL solubility and selective tumor-targeted accumulation. In our research, we revealed, for the first time, that XL binding to polyvinyl alcohol (PVA) enhances XL photophysical activity, providing the rationale for PVA application as a stabilizer for nanoformulations. Results of FTIR, DSC, and XRD revealed the physical interactions between XL and excipients, including PVA, indicating that the encapsulation maintained XL binding to PVA. The encapsulated XL exhibited higher photophysical activity compared to non-encapsulated substance, which can be attributed to the influence of residual PVA. Gamma-irradiation led to degradation of XL; however, successful sterilization of the samples was achieved through the filtration. Importantly, the encapsulated and sterilized XL retained cytotoxicity against both 2D and 3D tumor cell models, demonstrating the potential of the formulated NP–XL for photodynamic therapy applications, but lacked the ability to reactivate epigenetically silenced genes. These findings provide valuable insights into the design and characterization of PLGA-based nanoparticles for the encapsulation of photosensitizers.