bluuebunny/crossref_metadata_2025 huggingface dataset:
Registered clinical trials investigating ketamine and esketamine for treatment-resistant depression: A systematic review
Authors: Brendle Madeline , Ragnhildstveit Anya , Slayton Matthew , Smart Leo , Cunningham Sarah , Zimmerman Mackenzie H. , Seli Paul , Gaffrey Michael Santo , Averill Lynnette Astrid , Robison Reid
Published: January 2023

Background and Aims

Ketamine and esketamine have garnered interest in both psychiatric research and clinical practice for treatment-resistant depression (TRD). In this review, we examined registered trials investigating the therapeutic use of ketamine or esketamine for TRD, with the aim of characterizing emerging trends and knowledge gaps.

Methods

The ClinicalTrials.gov electronic registry and results database was queried from inception to February 5, 2022, adhering to elements of the PRISMA guideline, we evaluated trial eligibility in the qualitative synthesis. Data regarding study design, drug regimens, and measures were subsequently abstracted and descriptively analyzed.

Results

The search returned 86 records, of which 56 trials were included in the final review. The number of trials investigating ketamine and esketamine for TRD increased since 2008, with higher peaks observed in 2015 (n = 9) and 2021 (n = 9). Most trials were Phase 2 (13, 23.2%) or Phase 3 (11, 19.6%), gathering preliminary data on efficacy and/or further data on safety and efficacy with variant dosing and pharmacological approaches. By and large, trials examined ketamine and esketamine as individual versus combination treatments (45% and 25%, respectively). The Montgomery-Asberg Depression Rating Scale (MADRS) was most commonly used to assess clinical outcomes (75%).

Conclusions

There are increasingly large-scale and late-phase trials of esketamine over ketamine for TRD, coupled with efforts to centralize evidence on these medications. Yet several trials do not assess patient characteristics that may affect treatment response, such as age, sex, and race. By understanding these design limitations, scientists and clinicians can avoid research waste and funding bodies can judiciously direct support towards high priority research.
Resolving intragranular stress fields in plastically deformed titanium using point-focused high-energy diffraction microscopy
Authors: Li Wenxi , Sharma Hemant , Kenesei Peter , Ravi Sidharth , Sehitoglu Huseyin , Bucsek Ashley
Published: January 2023

The response of a polycrystalline material to a mechanical load depends not only on the response of each individual grain, but also on the interaction with its neighbors. These interactions lead to local, intragranular stress concentrations that often dictate the initiation of plastic deformation and consequently the macroscopic stress–strain behavior. However, very few experimental studies have quantified intragranular stresses across bulk, three-dimensional volumes. In this work, a synchrotron X-ray diffraction technique called point-focused high-energy diffraction microscopy (pf-HEDM) is used to characterize intragranular deformation across a bulk, plastically deformed, polycrystalline titanium specimen. The results reveal the heterogenous stress distributions within individual grains and across grain boundaries, a stress concentration between a low and high Schmid factor grain pair, and a stress gradient near an extension twinning boundary. This work demonstrates the potential for the future use of pf-HEDM for understanding the local deformation associated with networks of grains and informing mesoscale models.

Graphical abstract
Development of a process complexity index of low pressure die casting for early product design evaluation
Authors: Budiono Hendri Dwi Saptioratri , Nurdian Dian , Indianto Mohammad Akita , Nugroho Henky Suskito
Published: January 2023

The design of a product is key for the manufacturing industry to compete in the current era. Failure to plan a product design means losing in the market and falling behind competitors. One way to comprehensively evaluate one design is by analyzing its complexity. Complexity analyzes not only clear view parameters such as geometry and process time but also the whole design parameters, including its production process. This paper develops a process complexity index of low pressure die casting. A casting process is one unique process that depends on the melting and solidification of material in a die. A complexity analysis of low pressure die casting is yet to be done. Three different cylinder heads fabricated with low pressure die casting were used in the case study with the product’s types of 3SZ, 1TR, and 2TR. A process complexity analysis is performed based on the LPDC process’s physical and non physical parameters. The physical parameters are fixtures, tools, gauges, and machines. The non physical parameters are determined from the features and specifications of the low pressure die casting subprocess: setting, filling, solidification, and handling. The analysis successfully defines the complexity of each product, with 1TR having an index of 7.08, 2TR being 6.93, and 3SZ being 5.14. This developed complexity index can be utilized for early product design and cost estimation evaluation
Cluster analysis of the effectiveness of management of higher education institutions
Authors: Mambetkaziyev Aidar , Baikenov Zhassulan , Konopyanova Galina
Published: January 2023

The object of research is the internal structure of management in universities. The research problem is to confirm the causal relationship between management and rating. Higher education is one of the most important indicators of the level of development of the state. That is why many countries of the world attach great importance to the issue of the quality of higher education. Different international and national university ranking systems of universities were created to reflect the quality of education in the corresponding higher educational institutions. Currently, university ranking includes such criteria as quality of education, indicators of employment of university graduates, the demand for the graduates in the labor market, the symbiosis of science, education and business, and mobility of students. These indicators are a direct result of effective management in universities. Based on this hypothesis, the paper makes an assumption about the possibility of clustering universities in the Republic of Kazakhstan in order to determine the effectiveness of management. The authors consider three clustering models: clear and fuzzy clustering based on k-means and agglomerative cluster analysis. It should be noted that the clustering of universities makes it possible to determine some consistency in relation to the organization of university management. The division of universities into clusters according to the degree of deterioration in management makes it possible to create a kind of hierarchical ranking of the organization of management of university activities. This creates prerequisites for analyzing the internal structure of management in leading universities with the purpose of studying and adopting these practices by universities in lower clusters
Development of reference incident management model
Authors: Sembina Gulbakyt , Mayandinova Karina , Naizabayeva Lyazat , Sagnayeva Saule
Published: January 2023

One of the most important tasks of improving the information technology infrastructure of an enterprise is to increase the efficiency of the incident management system. The relevance of this study lies in the fact that at present the work of the technical support service in the conditions of a large flow of applications accelerates violation of the deadlines for resolution established by the business. It, in turn, leads to downtime of information systems and financial losses of the enterprise. This article analyzes the feasibility of introducing a third line of technical support to increase the proportion of incidents resolved within the framework of the Service Level Agreement adopted at the enterprise. A comparative analysis of the widely used two-level model with the proposed three-level model in this work is considered, using business process model notation. The effectiveness of the model is confirmed by automated computations using metrics, by calculating the rate and satisfaction coefficients within the framework of two and three levels of the model and then comparing these indicators to establish patterns. Thus, it is possible to track how successfully and timely incidents of information systems are resolved, which in turn directly reflects the availability and correct functioning of systems and the entire company.
The company's practical losses due to system downtime were calculated, as well as the resulting financial losses before and after the adopting of the three-level system, taking into account the associated costs to identify if the initiation of the model is justified and profitable.
Thus, the proposed model can be adopted by organizations in order to improve the quality of services provided by the IT department, to reduce the effect and impact of incidents on the performance and availability of systems that affect the formation of financial statements
Classifying wireless signal modulation sorting using convolutional neural network
Authors: Hamza Ekhlas , Aziez Sameir , Hummadi Fadia , Sabry Ahmad
Published: January 2023

Deep learning has recently been used for this issue with superior results in automatic modulation classification. Previous studies state that it is challenging to categorize a variety of modulation formats using traditional approaches; however, modulation classification is a crucial component of non-cooperative communication in wireless communication. The deep learning network was applied to solve the issue and get decent outcomes. This work uses a deep learning convolutional neural network (DLCNN) to classify three analog and eight digital modulation techniques by generating channel-impaired and synthetic waveforms as training data. The obtained DLCNN is tested by over-the-air indicators and a Software Define Radio(SDR) platform. The trained DLCNN estimates the modulation kind of each frame by taking 1024 samples of channel-impaired signals. The method includes generating several frames of 4-arry pulse amplitude modulation (PAM4) that are impaired with sampling time drift, Additive white Gaussian noise (AWGN), center frequency, and Rician multipath fading. The DLCNN predicts real inputs when receiving a signal with complex samples of baseband. Before updating the network coefficients and on all iterations, the data store transforms data from files and records it. This network takes about 50 minutes to train using in-memory data and 110 minutes to train using disk data. The evaluation of the trained DLCNN is carried out by obtaining the classification accuracy for the test frames. The obtained outcome demonstrates that the developed network can achieve an accuracy of about 94.3 % in roughly 12 epochs for such types of waveforms, which elapsed about 26 minutes for training. This will increase the efficiency of spectrum usage and detect the modulation type of the wireless communication receivers
Determining patterns of vertical load on the prototype of a removable module for long-size cargoes
Authors: Vatulia Glib , Lovska Alyona , Pavliuchenkov Mykhailo , Nerubatskyi Volodymyr , Okorokov Andrii , Hordiienko Denys , Vernigora Roman , Zhuravel Irina
Published: January 2023

The object of this study is the processes of occurrence, exposure to, and redistribution of loads in the supporting structure of a removable module for the transportation of long cargoes.
To adapt platform cars to the transportation of long loads, it is proposed to introduce a removable module with elastic-friction connections in the structure.
In order to select the optimal profiles for the removable module, in terms of minimal material consumption, the calculation was carried out in the Lira software package. Based on the calculation results, a spatial model of the concept of the removable module was built.
To determine the dynamic loads that act on the platform car loaded with a removable module, a mathematical simulation was carried out. It was established that the use of elastic-friction links in the structure of the removable module helps reduce its dynamic load, as well as the platform car, by 4.6 %. The resulting acceleration was taken into account when calculating the strength of the removable module. The calculation results showed that the strength of the removable module under operational loads is ensured.
A feature of the reported results is that the proposed design of a removable module makes it possible not only to adapt the platform car to the transportation of long loads but also to reduce its load in operation.
The scope of practical application of the results includes the engineering industry, in particular, railroad transport. Worth noting is that the conditions for the practical use of the results imply the introduction of elastic-friction links in the structure of the removable module.
The reported research will contribute to compiling recommendations for the design of modern vehicle structures, in particular removable type, as well as for improving the efficiency of rail transportation.
Investigating the impact of network topologies on the iot-based wsn in smart home monitoring system
Authors: Nourildean Shayma W. , Mohammed Yousra A. , Abdulhadi May T.
Published: January 2023

The object of this research is to present IoT WSN-based smart home monitoring system, which allows users to monitor and manage all of their appliances and home equipment via the Internet using established protocols. IoT is described as the connection of equipment and appliances to the Internet in order to monitor, report, and perform certain tasks. Wireless Sensor Networks (WSN) are considered as a key component in the IoT model's implementation. This research presented the IoT WSN platform using Riverbed Modeler Simulation Program in order to examine the network performance for different Wireless Sensor topologies (Star, Tree and Mesh). This platform consists of a number of scenarios with a number of sensors in each scenario. Each sensor is represented by the ZigBee end device, which sensed and collected data about the smart home and sent the collected data to the controller, which is represented by the ZigBee coordinator. The controller sends the data to the server to be monitored by the users through any gateway (Wi-Fi) after logging in using a specific application with three routing topologies on the controller. The results showed that IoT WSN tree topology is the best topology if the throughput is considered for improvement at the expense of data dropped with acceptable delay. Star topology improves the network performance in terms of data dropped and throughput when the number of sensors was increased. Mesh topology achieved the smallest data dropped with low throughput. Due to their features, these results were effective because they indicated that the selection of suitable routing topology played an important role in improving the degradation of IoT WSN performance due to the interference of Wi-Fi and ZigBee network since they utilized the same frequency band (2.4 GHz).
Designing a toolset for assessing the organizational and technological inertia of energy consumption processes at enterprises
Authors: Lesinskyi Valentyn , Yemelyanov Olexandr , Zarytska Oksana , Petrushka Tetyana , Myroshchenko Nataliia
Published: January 2023

The object of this study is the assessment of the organizational and technological inertia of energy consumption processes at enterprises. The task to design effective toolset for such an assessment was tackled.
The indicators for assessing the organizational and technological inertia of energy consumption processes at enterprises have been determined and systematized. The factors that influence the level of this inertia were highlighted. A method for decomposing the relative level of organizational and technological inertia of energy consumption processes has been developed.
The level of organizational and technological inertia of the processes of natural gas consumption was assessed on the basis of a sample of enterprises. It has been established that this level is quite high. In particular, the duration of lag in the reduction of natural gas consumption, averaged over 2016–2021, ranged from 1.3 to 1.8 years. At the same time, the relative level of organizational and technological inertia of the processes of consumption of natural gas in terms of its natural volumes ranged from 36.5 % to 47.9 %. The empirical results are explained by the presence of significant obstacles to the implementation of organizational and technological measures to save natural gas.
A feature of the designed toolset for assessing the organizational and technological inertia of energy consumption processes is that its use makes it possible to obtain a comprehensive and accurate assessment of the specified inertia. This toolset can be used by enterprises of all types of economic activity in assessing the reserves for reducing the organizational and technological inertia of energy consumption. In addition, the designed tools can be used by state authorities and local governments in the formation of strategies for energy-saving economic development
Effect of syzygium cumini leaf extract as a green corrosion inhibitor on API 5l carbon steel in 1M HCL
Authors: Riastuti Rini , Mashanafie Giannisa , Rizkia Vika , Maksum Ahmad , Prifiharni Siska , Kaban Agus , Priyotomo Gadang , Soedarsono Johny
Published: January 2023

Corrosion in API 5L steel under 1M HCl is a common issue; hence, creating a more effective and naturally-based inhibitor is critical. In this research, Syzygium Cumini leaf extract (SCLE) was used as a new green corrosion inhibitor under acidic conditions. The inhibition properties of the novel cumini extract were thoroughly characterized using potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), Fourier-transform infrared spectroscopy (FTIR), and atomic force microscope (AFM). The results show that the cumini inhibitor has excellent corrosion inhibition with 93 % inhibition efficiency. The adsorption behavior of the inhibitor follows the Langmuir Adsorption Isotherm due to the nearness of R2 to unity. The potentiodynamic and electrochemical measurements demonstrate the mixed type of corrosion inhibitor. Thermodynamic calculation of ΔGads is – 18.41 kJ mol-1 showing the physical adsorption process between the inhibitor and metals. Further inspection of ΔHads at ‒58.93 kJ mol-1 considers releasing energy during adsorption. The FTIR results agree with the increased growth of passive layers due to the adsorption of polyphenol and flavonoids on metals. Remarkably, the adsorption peak at 3266.59 cm-1 corresponds to the adsorption of –OH. The peak at 1612.56 and 1698.4 cm-1 is attributed to C=C and C=O functional groups. The above functional groups serve as adsorption centers to reduce the corrosion effect. The surface treatment of AFM indicated a good relationship with the functional group characterization and confirmed the significant corrosion rate reduction. This work can be used as a benchmark to develop a natural plant as a corrosion inhibitor.
Determination of heat transfer mechanisms during vacuum drying of solid-moist and liquid-viscous materials
Authors: Abdizhapparova Bakhytkul , Potapov Volodymyr , Khanzharov Nurlan , Shingissov Azret , Khanzharova Bayan
Published: January 2023

Most drying methods combine convective, conductive and radiation heat transfer processes. The share of each type of heat transfer may vary depending on the type and mode of drying, type of product, etc. In this study, the problem of determining the heat transfer mechanism of vacuum drying of solid-moist and liquid-viscous materials is solved. The objects of the study are Jerusalem artichoke tubers, camel and mare milk. The numerical values of the heat transfer components are found experimentally and their shares in the total heat flux are determined. During vacuum drying of Jerusalem artichoke at a medium pressure of 4 kPa and a temperature of 55 °C (with a layer height of 0.01 and 0.02 m), the convective component predominates (58.55 and 67.65 %). The share of thermal conduction (18.96 and 29.39 %) and radiation (13.39 and 12.05 %) is much lower. The mechanism of thermal conduction begins to prevail with an increase in the height of the material layer (0.03 and 0.04 m). The convective component is also dominant for vacuum drying of milk: at medium pressures of 6÷10 kPa and a temperature of 40 °C, its value for mare milk reaches 78.21 %, for camel milk – 73.33 %. The second most important is the share of radiation (19.45 and 22.58 %). Conductive heat transfer has the minimum indicators (5.66 and 6.17 %). The large values of the share of thermal conduction during drying of Jerusalem artichoke compared to milk are explained by the fact that heat transfer occurs inside the tubers due to conduction, and inside milk – due to convection. Insignificant shares of radiation are explained by low and medium vacuum values in the chamber. In the studied range, heat and mass transfer occurs due to molecular diffusion and convection. The results obtained can be used to formulate criterion heat transfer equations, in engineering calculations, and optimization of the vacuum dryer operation.
Determining patterns in the generation of magnetic fields when using different contact welding techniques
Authors: Levchenko Oleg , Polukarov Yury , Goncharova Olga , Bezushko Olga , Arlamov Olexandr , Zemlyanska Olena
Published: January 2023

The object of this study is the quantitative characteristics of magnetic fields induced during electric contact welding in various ways: contact point, arc-butt, capacitor point, contact-butt continuous, and pulsating fusion. The problem to be solved is the lack of necessary information regarding the electromagnetic safety of these welding techniques. A description of the proposed methodological approaches to determining the levels of magnetic fields, their measurement tools, and methods for assessing their impact on the welder's body is given. Based on the analysis and processing of the acquired oscillograms and spectrograms of magnetic fields, their quantitative characteristics were measured. To determine the general level of the polyfrequency magnetic field arising at contact welding, the proposed generalized indicator of the level of the magnetic field was used. It was established that during contact point welding by a stationary machine, the level of the magnetic field exceeds the maximum permissible value at the workplace in the range of 50–1000 Hz at a distance of 0.3 m from the welding electrodes. When manually welding in this way, the magnetic field level exceeds the permissible level in the frequency bands of 5–50, 50–1000 Hz directly near the electrical cable. Capacitor spot welding with direct current is characterized by exceeding the maximum permissible MP at the workplace in the high-frequency range of 1000–10000 Hz. During arc-butt welding, no excess of the maximum permissible levels of the magnetic field was detected at the workplace. It is shown that the spectral composition and magnitude of the magnetic field signal is determined by the welding technique and the initial parameters of power supplies. Orimani results can be used in the field of welding production and labor protection.
Identifying the influence of number of blades and distance between blades on tesla pump characteristics
Authors: Wahhab Kadhim Mohammed , Hayawi Rahman Mokdad
Published: January 2023

The main principle of the Tesla pump is to increase the shear stresses as a result of the rotation of the pump blades, and thus increase the kinetic energy of the fluid to form a mass flow. The types of mechanical pumps are many and the ways of their use are wide. Over the years, scientists have contributed to developing types of pumps to get the best pump efficiency. The rotational energy can be converted into a mass flow of the fluid that can be pumped. As the Tesla pump is one of the types that gives a wide impression of fluid mechanics, where the viscosity and shear stress of the fluid will be in the movement of the fluid particles and the formation of a centrifugal force that gives an active flow of the fluid. Tesla pump is one of the primitive pumps that can be modified to study this research paper and know the number of fins used and the optimal distance between them to obtain the best mechanical efficiency of the pump. Where the Tesla pump was designed with variable fins, 3, 6 and 11 fins were taken to compare them, and the distance between the fins was reduced from 10 mm to 5 mm with a change of 2.5 mm, where the changes that occur on the pump can be observed. Where the results proved that the value of the fins increases the flow velocity of the fluid, as the best case was at the fins number 11, where the flow velocity reached 13 m/s. As for the change of distance, it is an inverse relationship as the small distance between the fins impedes the movement of the fluid flow and thus reduces the value of the flow. In the case where the number of turbine blades is 11, shear stresses reached 401 Pa. Which is the best case compared to the rest of the cases. The mechanical movement of the water was significantly increased
Study of pathological changes in placentas of gestational diabetes mellitus and its association with fetal outcome
Authors: Rani A. Swarupa , Jacintha B. Nissy , Khatoon Khuteja , Harechandana M. , Mamatha Manchikanti
Published: January 2023

GDM is associated with an adverse fetal and neonatal outcome that often presents with macrosomia, birth trauma, neonatal hypoglycemia, and respiratory distress syndrome. The inclusion of GDM into 'the great obstetrical syndromes' emphasizes the role of the placenta in interactions between the maternal and fetal unit. 

The aim: To study pathological changes in the placentas of gestational diabetes mellitus and its association with fetal outcome.

Materials and methods: The Prospective study was conducted among pregnant women above the age of 18 years diagnosed with gestational diabetes attending the hospital. All patients are subjected to complete physical examination along with obstetric examination. All the routine investigations, including the complete blood counts, blood picture, RBS, RFT, LFT, OGTT, CUE and, ultrasonography with doppler, histopathological examination of the placenta after delivery.

Results: The weight of the babies born to GDM mothers and normal mothers were compared, and the GDM mother's baby weighed higher, meaning diabetes has an effect on the baby's weight which was statistically significant. Comparison of the placenta was made for cases and controls; the result suggested all the morphological parameters placenta - weight (p<0.001), diameter (p<0.001), area (p<0.002) and thickness (p<0.001) were statistically significant. The complications reported were respiratory complications, hypoglycemia, hyperbilirubinemia, meconium staining, polycythemia, sepsis and hypocalcemia. Babies of gestational diabetic mothers have a higher risk of developing neonatal complications than non-diabetic mothers. Villous oedema, villous fibrosis, syncytial knots, and fibrinoid necrosis is seen on histopathological examination was <0.05, and hence there was a significant difference between these findings in both the groups.

Conclusions: GDM is associated with the adverse fetal and neonatal outcome that often presents with respiratory complications, hypoglycemia, hyperbilirubinemia, meconium staining, polycythemia, sepsis and hypocalcemia. Including GDM into 'the great obstetrical syndromes' emphasizes the role of the placenta in interactions between the maternal and fetal unit
Diabetes mellitus in domestic cats: clinical cases from veterinary practice
Authors: Morozenko Dmytro , Vashchyk Yevheniia , Zakhariev Andriy , Seliukova Nataliia , Berezhnyi Dmytro , Gliebova Kateryna
Published: January 2023

The aim: to analyze clinical cases of diabetes mellitus in cats and establish the effectiveness of clinical and laboratory research and treatment of animals with the help of insulin therapy.
Materials and methods. The material for the study were domestic cats admitted to the veterinary medicine clinic "Doctor Vet" (Lviv).
Results. Clinical case 1. Cat Bonya, age 10 years, body weight 4 kg. symptoms: polyuria/polydipsia and weight loss. Examination: cachexia, weakness, pale mucous membranes, unsteady gait. Blood glucose - 20.4 mmol/l, urine analysis - pH=6.0, glucose ++++, no ketones detected. Diagnosis: diabetes. For glycemic control - caninsulin at 0.25 IU/kg every 12 hours. After the start of insulin therapy, the animal's condition improved, after 2 months - an attack of hypoglycemia, blood glucose 3.0 mmol/l. The introduction of insulin was stopped for 10 days, after 10 days the cat's appetite is normal, polyuria and polydipsia are not observed, body weight gain is 300 g, blood glucose without insulin therapy is 8.0 mmol/l.
Clinical case 2. Cat Eva, age 12 years, body weight 6.7 kg, symptoms: polyuria/polydipsia during the last two weeks, increased appetite, diet - raw meat, meatballs, buckwheat porridge, boiled carrots, beets. Blood glucose 22.9 mmol/l, urine analysis – pH = 6.0, glucose ++++, ketones +. Diagnosis: diabetes. Treatment: Lantus 2 IU subcutaneously every 12 hours. After the start of insulin therapy, the condition improved, after 2 months, blood glucose was 9.00 - 13.0 mmol/l; 15.00 – 8.0 mmol/l, 21.00 – 12.0 mmol/l, glucose and ketones are absent in the urine.
Conclusions. In the first clinical case, the cat there was a decrease in demand in insulin “Caninsulin” on the background of insulin therapy. In the second clinical case, insulin therapy with the help of "Lantus" insulin allows you to reach a level of glycemia at which diabetes stops progressing, the clinical condition of the animal normalizes, which indicates the effectiveness of the prescribed treatment. Thus, we can say that diabetes in small domestic animals is a rather severe endocrine pathology, which has typical clinical and laboratory symptoms and can be successfully treated with the help of a complex medical and diagnostic approach, based on insulin therapy
Prevalence of feline cardiomyopathy phenotypes and arterial thromboembolism
Authors: Petrushko Anastasiia , Grushanska Nataliia
Published: January 2023

The aim: To investigate the prevalence of cardiomyopathy (CMP) phenotypes and the weight of cardiogenic arterial thromboembolism (ATE) as a complication in cats. To determine the influence of age, breed and sex on the frequency of detection of CMP and ATE. Animals: One hundred and seventeen cats with various phenotypes of cardiomyopathies.

Materials and methods: the database of the veterinary center was analyzed. From 1066 studied cats, 117 stories of animal diseases were selected, in which the diagnosis of cardiomyopathy was established.

Results: In the experimental group, the prevalence of CMP was 11 % (HCMP - 94 %; DCMP - 3.4 %; RCMP - 2.6 %). Males were affected more often and had a more severe course. As the age of the animals increased, the relative frequency of heart failure increased slightly, but CMP was diagnosed more often in young animals. The Scottish Straight, Scottish Fold, European Shorthaired, European Longhaired, British Longhaired, and Canadian Sphynx can be considered susceptible breeds in Vinnytsia. There have been no cases of cardiomyopathy in Maine Coons. 57 % of cats with HCMP phenotype were asymptomatic. Arterial thromboembolism occurred in 14.5 % of animals with various CMP phenotypes. The lethality of ATE before discharge was 17.6 %, euthanized (different time period after the incident) 29 %.

Conclusion: HCMP phenotype is the most common. Probably, genetic factors related to sex and breed have a significant influence on the development of cardiomyopathy. More often, CMP phenotypes were diagnosed in younger animals. Heart failure develops more often in older animals. The number of animals with ATE and HCMP phenotype is high, but relative to the number of animals with heart failure, cats with DCMP were more prone. ATE occurred more often in females. Thromboembolism is more common in the European Longhair breed.
Ugarit - Rash Shamra: sua história
Authors: Kaefer José Ademar
Published: January 2023

A descoberta dos textos cuneiforme no sítio arqueológico de Ugarit – Rash Shamra e Rash Ibn Hani tem revolucionado o conhecimento que se tinha acerca da cultura, especificamente da religião, em todo o Levante. Evidentemente que o interesse maior se deu por conta da sua relação e proximidade com a cultura religiosa de Canaã, em particular de Israel e Judá e seu entorno mais próximo. Também é esse o interesse principal que conduz o presente estudo, mas não só. Em consonância com os contínuos novos achados arqueológicos e dos avanços nos conceitos de religião e história, também a literatura ugarítica necessita de nova leitura e nova interpretação. Tendo em mente esta meta, o presente manuscrito se propõe a apresentar de forma sucinta a longa e complexa história de Ugarit – Rash Shamra: localização, geografia, ocupação, economia, relações políticas, desenvolvimento, queda, escavação do sítio e achados mais relevantes. Com isso, oferecer um referencial sistematizado e seguro de onde partir para o estudo e compreensão do seu legado maior, sua literatura.
STUDY OF SORPTION PROPERTIES OF QUINOA SEEDS
Authors: Sokolovskaya O. , Valevskaya L.
Published: January 2023

The paper provides an analysis of the current state of the quinoa seed market in the world and the prospects for its production in Ukraine. The main producers of quinoa are Peru, Bolivia and Ecuador. Due to its rich chemical composition, quinoa seeds are rapidly gaining popularity. Ukrainian enterprises use quinoa grain for the production of various products and semi-finished products. Quinoa seeds are attracting increasing attention worldwide not only for their nutritional and functional properties, but also for their ability to grow in adverse climatic conditions. Increasing demand and rising global prices for quinoa is encouraging producers to adapt the crop to low altitudes and grow it in arid conditions. Breeders and scientists of different countries are actively working on the adaptation of quinoa seeds to growing in different regions, which has an important impact on food security. Quinoa grain imported to Ukraine requires long-term storage without weight loss and quality deterioration. An important influence on the state of grain mass during storage is its hygroscopicity, that is, the ability to sorb and desorb water vapor. Knowledge about the hygroscopic properties of grain is of practical importance for the scientific justification of the choice of rational modes of storage and post-harvest processing. The main characteristic of the hygroscopic properties of grain materials is the equilibrium moisture content, therefore, its determination is an important step in preserving grain quality. The equilibrium moisture content of quinoa grain was determined. The research was carried out by the generally accepted tensimetric method in the range of air temperatures ±(5...25)°С and relative air humidity 40...80%, which simulate the conditions of grain storage and correspond to long-term average data, corresponding to warm and cold seasons in Ukraine. The nature of the change in the equilibrium moisture content of quinoa grain depending on the temperature and relative humidity of the air has been established. As the relative humidity increases and the ambient temperature decreases, the equilibrium moisture content of the quinoa grain increases. Empirical coefficients were determined and an equation was proposed that describes the dependence of the equilibrium moisture content of quinoa grain on the parameters of the surrounding air, which can be used to predict its change. The obtained data are of practical importance for the selection of high-quality storage regimes for quinoa seeds.
DEVELOPMENT OF PRODUCTION TECHNOLOGY OF HIGH-PROTEIN FEED ADDITIVE FROM BY-PRODUCTS OF SUNFLOWER OIL PRODUCTION
Authors: Iegorov B. , Kananykhina O. , Turpurova T.
Published: January 2023

The oil and fat industry of Ukraine is one of the most powerful branches of the food industry, the development of which is of particular importance for assessing the country's food security. The screening showed that Ukraine occupies a leading position in the world market for the production of sunflower and sunflower oil, as well as the export of sunflower oil. The largest Ukrainian companies producing unrefined and refined sunflower oil are listed.The structural scheme of obtaining by-products, which are formed during the processing of oil crops, which have a rather high feed value and are used in feeding agricultural animals and poultry, is presented. Determining factors affecting the amount of by-products of vegetable oil production are characterized.Production of a high-protein feed additive based on sunflower meal, sunflower cake and mineral raw materials is proposed.A technological process scheme for the production of a high-protein feed additive has been developed, which provides for the following technological lines: a line for cleaning oilseeds; fall line of oilseeds; oil seed core pressing line; cake and meal preparation line; mineral raw material preparation line; dosage line; mixing line; granulation line.The production of the proposed high-protein feed additive in granulated form can be carried out at the existing oil processing enterprise in the meal granulation shop, which will make it possible to effectively use the by-products of sunflower oil production.
USING ULTRAVIOLET IRRADIATION TO DISINFECTCOMPOUND FEEDS
Authors: Yeryganov K. , Iegorov B.
Published: January 2023

Compound feeds are sources of not only nutrients required to maintain animals’ vital activity, but also of a complex of microorganisms inhabiting them. This complex develops in them after the heat treatment of raw materials (extrusion, conditioning, expansion, etc.), which creates non-competitive conditions for the foreign microorganisms to enter (in particular, from non-grain and animal raw materials). At the same time, the animal's gastrointestinal tract contains its own complex microbiome, which in young animals (at the time of switching to pre-starter) is not yet fully formed and not very stable. It can be disturbed by foreign microbiota, which will lead to a decrease in productivity. In addition, the foreign microbiota requires an immune response from the body, which is a very energy-consuming process. Therefore, the disinfection of compound feed for young animals at the stage of production and in finished form is reasonable and important. The most promising method of disinfection today is ultraviolet irradiation, which is widely used for disinfection of surfaces, air and water. It is cheap, easy in mounting and maintenance and effective without disrupting any properties of the product or feed. For compound feeds, it is currently used only on livestock farms, and is not used on production lines. Therefore, the task of this study was to test the effectiveness of ultraviolet irradiation of a compound feed for further implementation in manufacture. Irradiation with a bactericidal lamp of a model feed mixture (60% crushed wheat, 30% sunflower oilcake, 10% wheat bran) was conducted. The numbers of MAFAnM (mesophilic aerobic and facultatively anaerobic microorganisms) declined from 1 million to 20 thousand cells per gram after 5 hours (300 minutes) of UVC exposition (254 nm wavelength). The diagram obtained coincides well with the reference diagram for a typical bacterial strain and shows that the use of ultraviolet irradiation is quite effective even without requiring a long-time exposition. Therefore, it can be used industrially to disinfect compound feeds and their raw materials.
Народне богослов’я людської діяльності та праці в українських приказках і прислів’ях
Authors:   Narodowa Akademia Nauk Ukrainy NANU (ukr. Національна академія наук України, НАНУ), Тарасюк Iрина
Published: January 2023

The author of this article analyses a stratum of Ukrainian proverbs which by its semantic content constitutes a kind of popular theology of human activity and labour. The meaning of a number of paremies reflects the inner world of a religious person, wherein the individuality's development via daily labour is consistent with the plan of providence. According to popular Christian conceptions of God, He provides aid in every deed, word, thought, and wish. In popular religious cultural traditions, as well as in ecclesiastical traditions, rational activity is the aim and norm of all earthly human life; economic activity is included in God's plan, and is considered a positive value.
Жінка в українській історичній белетристиці 1880–1890-х років
Authors:   Рівненський державний гуманітарний університет (РДГУ), Кирильчук Олександр
Published: January 2023

Ukrainian historical fiction of the late nineteenth century is a strategy which outlines the characteristics of national identity. Presence of a woman in such models has a particular semantic role. In Ukrainian historical novels the feminine role is sometimes projected on the plane of patriarchal axiology and in some cases becomes masculinum under militant discourse of the past. The image of a woman in Ukrainian historical fiction of 1880–1890’s makes it possible to outline the intersection of the colonial and anti–colonial narratives.
Трансформація прийомів детективної оповіді в романі Оксани Забужко Музей покинутих секретів
Authors:   Запорізький державний медичний університет, Гребенюк Тетяна
Published: January 2023

The aim of this paper is to analyze the transformation of the narrative means and devices of the traditional detective novel used for investigating the mystery of woman’s destiny in the O. Zabuzhko’s novel The Museum of Abandoned Secrets. Detective themes in the narrative of this novel are generally recognized in the discourse of this literary work. An over-rational approach to the detective investigation in the novel is closely related to several factors, including the author’s concern with the problems of modern Ukrainian’s national identity. The work analyzed is a postcolonial novel, and this is embodied in all aspects of its content. Mystery of womanhood, heroes’ love relationships, and investigation of mysterious deaths - all this problems are marked by postcolonial perspective. Analysing peculiarities of author’s transformation of tools of the traditional detective narration about ”investigation” of the three heroines’ mysteries we find out several special features. First, the purpose of Daryna’s investigation is “to get ‘story’ out of Vlada’s life”. Secondly the place of insight, enlightenment in Daryna’s “detective” activity is also very specific. Unlike the traditional detective novel, in 0. Zabuzhko’s one the main “tool” of getting an answer is intuitive enlightenment. Thirdly, Adrian’s character is important not only in the explication of the love line of the novel, but also in “investigative” narrative. Adrian is an interpreter of spiritual movements and emotional states of hers.
Ґендерна специфіка реалізації опозиції „я”–„інший” у поезії Сергія Жадана та Маріанни Кіяновської
Authors:   Дніпровський національний університет імені Олеся Гончара, Шаф Ольга
Published: January 2023

The functionality of the ”I"-”Other” opposition, which is the gender marker of M. Kijanowska’s and S. Zhadah’s lyric is discussed. Particular emphasis is put on the gender-specific features of the expression of the attitude to the male/female structurized as “own”-“alien”, “subject”-“object”.
Між національними та інтернаціональними тенденціями термінотворення: формування української астрономічної термінології наприкінці ХІХ–на початку ХХ століття
Authors:   Львівський національний університет імені Івана Франка, Богуш Оксана
Published: January 2023

Ukrainian scientific astronomical terminology has been rapidly evolving in the late XIX and early XX century due to the publication of scholarly works on astronomy in Ukrainian. During this period, the development of astronomical terminology system, as well as other subsystems of the scientific language was not a normal, natural way of challenging conditions of stateless Ukrainian nation. In the article the author discusses the influence of linguistic and extra-linguistic factors on the creation of the Ukrainian language and national scientific terminology. For example, I present Ukrainian astronomical terminology’s influence on national and international trends in terms of formation and development of astronomical terminological Ukrainian language.
Ukraińskie słownictwo informatyczne wobec wpływów języka angielskiego i rosyjskiego - przegląd wybranych postów forum internetowego Domivka.Net
Authors:   Uniwersytet Wrocławski, Jóźwikiewicz Przemysław
Published: January 2023

The article presents an overview of the issues related to the formation of Ukrainian IT terminology with particular focus on the roles of the Russian and English languages. However, much more attention is devoted to the analysis of selected posts from Domivka.NET Internet forum, on which its users have dealt with, among others, the problems of translating mainly English IT terminology into Ukrainian.
Vikladachі Kiїvskogo derzhavnogo unіversitetu v perіod stalіnskikh represіjj (1933 – 1941 rr.)
Authors: Kazmirchuk Marіja
Published: January 2023

Lecturers of Kiev State University in the period of Stalinist repression (1933 – 1941). Restoring classic university system aft er series of experiments of Soviet authority over the education system contributed to the revival of the Kiev State University. However, further Stalin’s repressions aggravated the situation of teachers and students and the science in general. Th e consequence of political repression and persecution of the teachers of the Kiev State University was the fall of the level of teaching. Biographies of individual faculty members in the period from 1933 to 1941 are proof of cruel repressive policies of the totalitarian Soviet state.
Зобразити війну
Authors:   Київський університет імені Бориса Грінченка, Полішук Ярослав
Published: January 2023

How to Represent War. The hybrid warfare going on in Donbass has had consequences on the informational and cultural spheres in Ukraine. It is a war for influence where Ukraine cannot adequately confront Russia because it does not have the necessary recourses and a developed media culture. The number of literary works about the war published in the last few years show that Ukrainian writers want to challenge the discourse on war. Between 2014 and 2016 numerous novels, stories, essays, reports, and poems were published by such writers as Halyna Vdovychenko, Yevhen Polozhiy, Sergei Lozko, and Vladyslav Ivchenko. These authors try to show all the horror of the war and the changing attitudes and consciousness of Ukrainians. The issue of forming a new Ukrainian collective identity is reflected in contemporary literature.