bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between hemogram parameters and the development of contrast-induced nephropathy in patients presenting with non-ST-elevation myocardial infarction
Authors: Dönmez Esra , Özcan Sevgi , Şahin İrfan , Okuyan Ertuğrul
Published: August 2023

Objectives

Hemogram parameters such as mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLr), red cell distribution width and platelet distribution width are widely used inflammatory indicators to assess prognosis in various cardiovascular diseases. In this study, we aimed to investigate the role of hemogram parameters to predict the development of contrast-induced nephropathy (CIN) in patients presenting with non-ST segment elevation myocardial infarction (non-STEMI) and treated with percutaneous coronary intervention (PCI).

Methods

All pateints who underwent PCI with a diagnosis of non-STEMI between 2017 and 2020 in our center were included retrospectively in this study.

Results

A total of 387 patients were included in this retrospective study. Advanced age (p=0.001, β:0.005, OR [95 % CI]: 0.002–0.007), diabetes mellitus (p=0.013, β:0.205, OR [95 % CI]: 0.150–0.260), congestive heart failure (p=0.009, β:0.095, OR [95 % CI]: 0.024–0.166), volume of contrast medium (p=0.008, β:0.241, OR [95 % CI]: 0.184–0.392), MPV (p=0.02, β:0.047, OR [95 % CI]: 0.028–0.065) and NLr (p=0.001, β:0.052, OR [95 % CI]: 0.040–0.063) were found as independent risk factors associated with CIN development according to multivariate logistic regression analysis. A cut off value of 5.5 for NLr was associated with 79.6 % sensitivity and 79.5 % specificity and 9.05 for MPV was associated with 64.1 % sensitivity and 58.7 % specificity in prediction of CIN development.

Conclusions

Hematological parameters, assessed by routine blood count analysis may serve as a promising and useful marker for CIN especially when used in combination with traditional risk factors. MPV and NLr were demonstrated as predictors of CIN development in non-STEMI patients who were treated with PCI in our study.
Ground states of Schrödinger systems with the Chern-Simons gauge fields
Authors: Jiang Yahui , Chen Taiyong , Zhang Jianjun , Squassina Marco , Almousa Nouf
Published: August 2023

We are concerned with the following coupled nonlinear Schrödinger system:

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\left\{\begin{array}{l}-\Delta u+u+\left(\underset{| x| }{\overset{\infty }{\displaystyle \int }}\frac{h\left(s)}{s}{u}^{2}\left(s){\rm{d}}s+\frac{{h}^{2}\left(| x| )}{{| x| }^{2}}\right)u={| u| }^{2p-2}u+b{| v| }^{p}{| u| }^{p-2}u,\hspace{1em}x\in {{\mathbb{R}}}^{2},\hspace{1.0em}\\ -\Delta v+\omega v+\left(\underset{| x| }{\overset{\infty }{\displaystyle \int }}\frac{g\left(s)}{s}{v}^{2}\left(s){\rm{d}}s+\frac{{g}^{2}\left(| x| )}{{| x| }^{2}}\right)v={| v| }^{2p-2}v+b{| u| }^{p}{| v| }^{p-2}v,\hspace{1em}x\in {{\mathbb{R}}}^{2},\hspace{1.0em}\end{array}\right.

where

ω
,
b
>
0

\omega ,b\gt 0

,

p
>
1

p\gt 1

. By virtue of the variational approach, we show the existence of nontrivial ground-state solutions depending on the parameters involved. Precisely, the aforementioned system admits a positive ground-state solution if

p
>
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p\gt 3

and

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large enough or if

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small.
Analysis of tool wear and surface roughness in machining of AISI 4462 duplex stainless steel
Authors: Sönmez Fikret
Published: August 2023

Machining is one of the most precise manufacturing methods used in the manufacturing of machine parts. In machining, significant tool wear is observed due to cutting tool-to-workpiece contact. Controlling tool wear and minimizing the effect of tool wear in this method is an important research topic. In this study, machinability tests were carried out on AISI 4462 duplex stainless steel materials, which are in the hard-to-cut material class. In the experiments, the changes in tool life and surface roughness were analyzed by using 150, 180, and 210 m/min cutting speeds; 0.1 mm feed; and 0.8 mm depth of cut. Increasing cutting speed significantly increased wear and reduced tool life. However, experiments with cutting speeds of 180 m/min and 210 m/min had the same tool life values. In addition, significant notch wear and BUE formation were observed on the tool surface. Besides, it was determined that the surface roughness deteriorated due to tool wear. In addition, surface deterioration due to chip wrapping was also observed in many passes.
Estudio del marco normativo para los emprendimientos turísticos en Cuba
Authors: Sosa Vera Rita C , Sanchez Díaz Yaira , Guerra Bretaña Rosa Mayelin
Published: August 2023

El turismo en Cuba ha aumentado la participación de los emprendimientos privados, que necesitan herramientas para elevar su calidad y competitividad. Por ello, el objetivo de este trabajo es identificar la base normativa aplicable para contribuir al cumplimiento de los requisitos de calidad en los emprendimientos turísticos cubanos. A través de una investigación descriptiva de tipo cualitativo, que permitió análizar y síntetizar el contenido de los documentos rectores a la actividad turística en el país y de las normativas aplicables, se realizó un ejercicio de confirmación con un grupo focal de 15 miembros de emprendimientos turísticos privados sobre una muestra intencional, centrando la atención en los establecimientos de alojamiento (12) y restauración (3). Se evidencia la existencia de un amplio conjunto de normas jurídicas y técnicas relacionadas con los negocios de alojamiento y restauración. Sin embargo, estas no se utilizan como sería necesario en el sector de los emprendimientos turísticos privados y no se cuenta con los espacios e instrumentos suficientes para la capacitación de los emprendedores.
Instrumento de diagnóstico para la integración de la gestión de la calidad e innovación en biomateriales
Authors: Almaguer Maelys Hernández , Guerra BretañaGuerra Bretaña Rosa Mayelin , Valencia Bonilla María Beatriz
Published: August 2023

La implementación y mejora del proceso de gestión de la innovación, para alcanzar desempeños superiores, es una temática de gran pertinencia y actualidad en las universidades cubanas contemporáneas. La integración de sistemas de gestión aumenta la capacidad de reacción en las organizaciones frente a las nuevas necesidades o expectativas de las partes interesadas, ya que se armonizan los criterios en cuanto a responsabilidades, planificación, ejecución, medición y seguimiento de los procesos. El objetivo del presente trabajo es diseñar un instrumento para el diagnóstico de la situación inicial con vistas a la integración de los sistemas de gestión de la calidad y la innovación, en el sector de los dispositivos médicos, específicamente, en un centro universitario dedicado a la investigación, desarrollo e innovación en biomateriales. Se realizó una investigación cualitativa, basada en el análisis de la normativa aplicable objeto de integración : NC-ISO 9001:2015 para la gestión de la calidad, NC-ISO 13485:2018 para los requisitos regulatorios y la UNE 166002:2021 para la gestión de la investigacion, el desarrollo y la innovacion. Como resultado, se armonizaron los requisitos comunes y específicos para conformar una lista de chequeo con 63 elementos a considerar. Este instrumento puede ser tomado como referencia por cualquier organización en el sector de los dispositivos médicos que desee integrar los sistemas de gestión de la calidad y la innovación.
The Effectiveness of Problem-Based Learning in Acquisition of Knowledge Using Online Learning
Authors: Rawash Hassan , Alawamreh Ali Ratib , Obeidat Abdallah Mishael , Nawafleh Ahmad h
Published: August 2023

The adoption and use of creative teaching techniques, such as problem-based learning using online learning have relied upon improvement in order to improve educational outcomes.  Regardless of the fact that problem-based learning is facilitated by online learning and has many clear advantages, it is still developing or at a very early level in many developing countries. Problem-based learning is a student-centered method where students study a subject by using online learning to collaborate in groups to solve an open-ended challenge. The research design was a cross-sectional field survey, was used in quantitative research approaches using PLS analysis. Additionally, the study's target population is all the class teacher students at private Universities. The author reviews the study on the investigation of influencing factors for problem-based learning strategy with online learning in Jordan to improve the education system as well.  The findings demonstrated a positive influence between key factors and intention to use and this result enhance acquisition of Knowledge using online learning for Class Teacher students.
Comparison of the body mass index (BMI) in physical education students, established by anthropometric, self-report and figure test techniques
Authors: Clarisa Isabel Rodríguez , Jorge Omar Olivera , María Eugenia Carrizo , Cazuza Walter Brizuela , Ángel Abel Salas
Published: August 2023

The purpose of the study was to compare the BMI according to different measurement techniques and to analyze differences between age and sex of Physical Education students. Type of descriptive research with a non-experimental cross-sectional research design. 107 students from Catamarca (Argentina) participated, 67 men (62.6%) and 40 women (37.4%) between 21 and 40 years old. Body weight (self-reported and real) will be reduced, to estimate the BMI the formula will be improved: models weight (kg) / height (m2) and to determine the perception by figures, the 7 anatomical sheet of Montero will be taken. The real BMI of 24.59 kg/m2 was established, self-reported BMI of 24.25 kg/m2 and a perceived BMI by figure of 24.06 kg/m2, 88.8% of the students are of normal weight. . The results determined significant differences of p<.001 in all the study variables between men and women. In the sample in general, significant differences were found between the real and self-informed height (p<.001) and between the real BMI with self-reported and with that perceived by figures (p<.05). The men turned out to be more effective in the perception of the figure and the women in the self-report with respect to the real BMI. Positive and significant correlations are presented between the real and self-perceived measurements in each of the variables, highlighting the real BMI with the self-reported BMI (r =915) and with the BMI perceived by figures (r =629) with significance. (p< .001). It is concluded that the BMI established by the techniques of self-report and perception by figures, underestimate the BMI measured by anthropometry, being the self-report technique the most effective of them, obtaining a high connection with the real BMI and with a high predictive value of estimation of the same.
Pharmacokinetics of dalteparin and nadroparin for thromboses in children with oncological diseases
Authors: VV Dmitriev , IV Begun , MB Borisenok
Published: August 2023

Objective: evaluate the pharmacokinetics and pharmacodynamics of nadroparin and dalteparin in thrombosis that occurred in children with malignant neoplasms. Materials and methods: The results of 52 pharmacokinetic studies involving 34 patients with oncological diseases, whose treatment was complicated by venous thrombosis, were analyzed. The median age of patients was 14.5 (7–18) years. Depending on the daily dose and the type of heparin administered, the results of pharmacokinetic studies were divided into 6 groups. Dalteparin sodium: against the background of chemo-induced thrombocytopenia, subcutaneous administration of dalteparin at a dose of 51.0 (40.0–72.0) anti-Xa IU/kg every 12 hours – 6 observations; subcutaneous injection every 12 hours at a dose of 100.5 (91.0–141.0) anti-Xa IU/kg – 18 observations; long-term continuous intravenous infusion at a constant rate at a daily dose of 201.0 (180.0–265.0) anti-Xa IU/kg - 6 observations. Nadroparin calcium: 62.0 (53.0-71.0) anti-Xa IU/kg every 12 hours - 6 observations; 93.5 (80.0–117.0) anti-Xa IU/kg every 12 hours – 10 observations; subcutaneous injection at a dose of 203.0 (170.0–236.0) anti-Xa IU/kg once a day - 6 observations. Results: We confirmed that in the acute period of thrombosis in children, the most optimal way to administer low molecular weight heparin is intravenous infusion of dalteparin sodium at a constant rate. Subcutaneous injection of 50% of the daily dose of LMWH at intervals of 12 hours is preferable to a single injection of 100% of the daily dose every 24 hours. There were no significant advantages of nadroparin compared with dalteparin when using anticoagulants in comparable doses in case of venous thrombosis, which complicated the treatment of children with malignant neoplasms. Conclusion: Control over the adequacy of the dose of LMWH can be performed at any stage of treatment. The specific anti-Xa activity of nadroparin and dalteparin needs to be checked before the next subcutaneous injection and between 3 and 4 hours after administration. An increase in chronometric indicators of blood coagulation indirectly reflects the presence of an anticoagulant in the blood, but does not allow an objective assessment of the achievement of a therapeutic effect.
Marine aquaculture in Cuba: What to do for its development in the current historical context?
Authors: Hernandez Luis Remedios
Published: August 2023

Cuba is an archipelago, its largest island has 5746 km of coastline and its insular platform has a surface similar to its arable area. However, marine culture is not a branch of aquaculture that has been definitively established. Fish farming in cages is considered a productive alternative, which alleviates the capture of marine waters and opens up unimaginable development prospects. Attempts at its initiation and development have been hampered by many factors; some objective and others subjective. This work allows to make an approach to these reasons, and to assess the existing possibilities to direct the marine culture in the right direction.
Improving the Documentation of Penicillin Allergy Labels Among Pediatric Inpatients
Authors: Hampton Laura L. , DeBoy Jason T. , Gunaratne Aruni , Stallings Amy P. , Bell Tara , Phillips Michael A. , Kamath Sameer S. , Sterrett Emily C. , Nazareth-Pidgeon Kristina M.
Published: August 2023

BACKGROUND AND OBJECTIVES

Penicillin allergy is the most common medication allergy, and the penicillin allergy label is commonly over-applied without adequate reaction history inquiry or documentation. Because penicillin allergy labels are often applied in childhood and carried into adulthood, we sought to increase the completeness of reaction history documentation from 20% to 70% for pediatric hospital medicine patients and from 20% to 50% for all other pediatric inpatients within 12 months. As a secondary outcome, we also aimed to increase the proportion of delabeling unnecessary penicillin labels to 20% for all pediatric inpatients.

METHODS

To address our aims, our quality improvement initiative included education for pediatric faculty and staff, development and implementation of a clinical pathway for allergy risk stratification, and electronic health record optimizations. Statistical process control charts were used to track the impact of the interventions facilitated by an automated dashboard.

RESULTS

Within 12 months of interventions, the completeness of allergy labels improved from 20% to 64% among patients admitted to the pediatric hospital medicine service and improved from 20% to 45% for all other pediatric inpatients. The frequency of penicillin allergy delabeling remained unchanged; however, 98 patients were risk stratified and 34 received outpatient allergy referrals for further testing. The number of adverse drug reactions to penicillin, a balancing measure, did not change during the study period.

CONCLUSIONS

We increased the completeness of penicillin allergy documentation using a standardized workflow facilitated by a multidisciplinary clinical pathway. With ongoing efforts, more penicillin delabeling in low-risk patients is anticipated.
Quality Improvement to Reduce High-Flow Nasal Cannula Overuse in Children With Bronchiolitis
Authors: Treasure Jennifer D. , Lipshaw Matthew J. , Dean Preston , Paff Zachary , Arnsperger Anita , Meyer Justin , Gillen Matthew , Segev Natalie , Woeste Laura , Mullaney Randi , O’Neill William , Fallon Anne , Gildner Candace , Brady Patrick W. , Statile Angela M.
Published: August 2023

BACKGROUND

High-flow nasal cannula oxygen therapy (HFNC) is increasingly used to treat bronchiolitis. However, HFNC has not reduced time on supplemental oxygen, length of stay (LOS), or ICU admission. Our objective was to reduce HFNC use in children admitted for bronchiolitis from 41% to 20% over 2 years.

METHODS

Using quality improvement methods, our multidisciplinary team formulated key drivers, including standardization of HFNC use, effective communication, knowledgeable staff, engaged providers and families, data transparency, and high-value care focus. Interventions included: (1) standardized HFNC initiation criteria, (2) staff education, (3) real-time feedback to providers, (4) a script for providers to use with families about expectations during admission, (5) team huddle for patients admitted on HFNC to discuss necessity, and (6) distribution of a bronchiolitis toolkit. We used statistical process control charts to track the percentage of children with bronchiolitis who received HFNC. Data were compared with a comparison institution not actively involved in quality improvement work around HFNC use to ensure improvements were not secondary to the COVID-19 pandemic alone.

RESULTS

Over 10 months of interventions, we saw a decrease in HFNC use for patients admitted with bronchiolitis from 41% to 22%, which was sustained for >12 months. There was no change in HFNC use at the comparison institution. The overall mean LOS for children with bronchiolitis decreased from 60 to 45 hours.

CONCLUSIONS

We successfully reduced HFNC use in children with bronchiolitis, improving delivery of high-value and evidence-based care. This reduction was associated with a 25% decrease in LOS.
Characteristics and Results of Pediatric Medical Device Studies: 2017–2022
Authors: Quazi Sabrina , Narang Claire , Espinoza Juan C. , Bourgeois Florence T.
Published: August 2023

OBJECTIVES

The development of medical devices for children faces unique challenges that have contributed to a paucity of devices specifically designed and tested for children. Increased knowledge on research activities for pediatric devices can guide optimal study design and ensure timely dissemination of clinical findings.

METHODS

We performed a cross-sectional analysis of interventional studies registered on ClinicalTrials.gov, initiated January 1, 2017, through December 12, 2022, evaluating a Food and Drug Administration–regulated class II or III device, and enrolling any pediatric patients (aged ≤17 years). Data were extracted from ClinicalTrials.gov on study characteristics and from Devices@FDA on device features. For completed studies, we determined whether results were reported in a peer-reviewed publication as of December 27, 2022.

RESULTS

Among 482 studies, 406 (84.2%) examined a class II device and 76 (15.8%) a class III device. The most common device types were diabetes-related devices (N = 57, 11.8%) and monitors and measurement devices (N = 39, 8.1%). Most studies were single-center (N = 326, 67.6%), used a nonrandomized (N = 255, 52.9%), open label (N = 350, 72.6%) design, and were funded by academic institutions (N = 278, 57.7%) or industry (N = 142, 29.5%). A total of 291 (60.4%) studies included a primary outcome of only efficacy without safety endpoints. Among completed studies, more than half (N = 64, 51.6%) enrolled <50 participants and 71.0% (N = 88) <100. After median follow-up of 3.0 years, results were available in publications for 27 (21.8%) completed studies.

CONCLUSIONS

Our findings serve to inform programs and initiatives seeking to increase pediatric-specific device development. In addition to considerations on ensuring rigorous trial design, greater focus is needed on timely dissemination of results generated in pediatric device studies.
Endothelial function disorders in children with COVID-19 infection: results of own study
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Mukvich O.M. , Omelchrnko L.I. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Matviyenko I.N. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Ignatova T.B. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Vdovina N.M. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv
Published: August 2023

Purpose - to learn the features of clinical condition and state of endothelial function as the marker of the development of cardiovascular pathology in children who suffered from COVID-19. Materials and methods. The research group consisted of 70 children aged 7-14 without chronic pathology who suffered from COVID-19 and had laboratory confirmation of the disease. Assessment of the functioning of the vessels’ endothelium was done by studying the dynamics of blood flow in the brachial artery and changes of it diameter at rest and during reactive hyperemia after an occlusion test. Statistical assessment of the obtained data was carried out by the application package «Statistica 10.0 for Windows» using the method of variational statistics. Student’s t-test was calculated to assess the reliability of mean values differences. Results. The state of endothelial function show that 85.4% of children after COVID-19 infection had signs of endothelial dysfunction, mainly hypoergic (32.9%) and paradoxical (30%) forms, while normoergic function of the endothelium was found only in 14.6% of children. In the same time in the group of children who did not suffer from COVID-19, was found that the normorergic form registrated in 80.0%, hyperergic endothelial dysfunction was found in 13.3% of children, and hypoergic - in 6.7% of children. Paradoxical endothelial dysfunction was not found in any child from this group. Conclusions. COVID-19 infection has negative consequences on the endothelium function and contributes to the development of endothelial dysfunction regardless of the severity of the disease course. Our results obtained the need of future study to develop an affordable and low-cost algorithm for routine use and identification of children with markers of lesion of cardiovascular system. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Bronchopulmonary dysplasia risk prediction in prematurely born children
Authors:   Dnipro State Medical University, Ukraine, Tovarnytska A.O.
Published: August 2023

Bronchopulmonary dysplasia (BPD) is one of the most frequent outcomes of prematurity. Relatively late diagnosis and development of formidable complications that can affect the quality of life in adulthood, determine the need for early BPD prognosis for the timely appointment of effective therapy. Purpose - identification of informatively significant clinical and anamnestic risk factors of BPD based on retrospective analysis and mathematical model creation for the prediction of chronic respiratory disease risk development in prematurely born children. Materials and methods. A retrospective analysis of the medical histories of 280 prematurely born children who were treated in neonatal units was conducted. With the help of sequential Wald analysis, 53 clinical and anamnestic indicators were analyzed, for each of them the relative risk (RR) and diagnostic coefficient (DC) were calculated. Results. Significant, prognostically unfavorable factors for BPD development are gestational age ≤28 weeks (RR=20.30); birthweight ≤1500 g (RR=3.08); duration of non-invasive combined respiratory support over 18 days (RR=3.74); Apgar score 1-3 at the first minute (RR=4.69) and 4-6 at the fifth minute of life (RR=4.19); newborn anemia (RR=3.12); invasive artificial lung ventilation for more than 13 days (RR=5.12). The probability of BPD increases substantially with the presence of retinopathy of the II and III degrees (RR=16.4 and RR=10.15, respectively). Interestingly, breastfeeding markedly prevented BPD development (RR=0.29). Furthermore, a mathematical model is represented to determine BLD development prediction and to diagnose this disease. Conclusions. High validity indicators and ease of use of the mathematical model for the BPD development prediction in prematurely born children make it possible to recommend it in the practice of neonatologists and pediatricians. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.
Biomedical Engineering Lab Manual, Volume 1
Authors: Breen Sarah
Published: August 2023

The lab manual was written as the first installment that coincides with two lab courses taught at the University of Oklahoma (BME3171, BME3181). These courses are designed to provide Biomedical Engineering students with lab skills and experience in biomedical engineering research and clinical techniques. This manual is used with BME3171 Lab 1 and the following topics are covered in this lab manual; functional human models, musculoskeletal lever systems, bioimaging (ultrasound), bioelectricity (electromyography), & uni-axial testing.
Biomedical Engineering Lab Manual, Volume 2
Authors: Breen Sarah
Published: August 2023

The lab manual was written as the second installment that coincides with two lab courses taught at the University of Oklahoma (BME3171, BME3181). These courses are designed to provide Biomedical Engineering students with lab skills and experience in biomedical engineering research and clinical techniques. This manual is used with BME3181 Biomedical Engineering Lab 2 and the following wet lab topics are covered in this lab manual; bioimaging, cell culture, tissue engineering, live-dead and DNA assays.
Projeto Larga Escala: conceitos, história e atualidade a partir da resolução CIPLAN n.º 15, de 11 de novembro de 1985
Authors: Rodrigues Tereza Miranda , Johnson Guillermo Alfredo
Published: August 2023

RESUMO O Projeto Larga Escala é foco deste artigo. Não obstante inúmeras publicações, nossa intenção foi investigá-lo na perspectiva histórica, por sua importância no processo de formulação de políticas educacionais em saúde. Apresentamos, de forma sistematizada, aspectos conjunturais, históricos e conceituais que revelam decisões, posições e escolhas, nos planos do discurso e da política em seu entorno. O método utilizado foi de análise documental. Conceitos como ‘formação’, ‘integração ensino-serviço’ e ‘metodologia’ mostram a dinamicidade do Projeto Larga Escala no tempo. Sua base conceitual oferece substrato para novas propostas educacionais no setor, como a Política Nacional de Educação Permanente em Saúde, do Ministério da Saúde.
Saúde e envelhecimento em periódicos de saúde brasileiros (2000-2009)
Authors: Ribeiro Ludmila Gonçalves , Aragaki Sérgio Seiji
Published: August 2023

RESUMO Diante do rápido e crescente aumento da população idosa no Brasil e no mundo, nosso objetivo foi entender as práticas discursivas e os sentidos produzidos a respeito do binômio saúde-envelhecimento, em periódicos da Biblioteca Virtual em Saúde, no período de 2000 a 2009, sob a perspectiva teórica do construcionismo social. Foi feita a seleção do material por meio de descritores, títulos e resumos, sendo construídas categorias analíticas dos artigos escolhidos. Concluímos que o tema tem sido crescentemente mais estudado. Persistem sentidos negativos e positivos relacionados aos idosos e ao envelhecer. Apesar disso, os idosos podem ter uma velhice ativa, saudáve e com qualidade de vida.
O significado da gravidez na adolescência para um grupo de meninas de baixo poder aquisitivo de Fortaleza, Ceará: uma abordagem a partir da arte terapia
Authors: Queiroz Danielle Teixeira , Heukelbach Jorg , Pessoa Sarah Maria Fraxe
Published: August 2023

RESUMO Este estudo objetivou conhecer o significado da gravidez na adolescência em uma comunidade de baixa renda, em Fortaleza (CE). Foi feita pesquisa qualitativa compreensiva com 15 adolescentes nuligrávidas, utilizando-se a arte terapia. Foram elaboradas quatro práticas expressivas, gerando três temáticas: adolescência - fase feliz, mudança na adolescência e responsabilidade com mudança na dinâmica familiar pela descoberta da gravidez. As adolescentes revelaram uma representação muito positiva de si mesmas; entretanto, com dificuldades financeiras, privação emocional, violência familiar e problemas de segurança. O significado da gravidez revelou maturidade das participantes, mesmo sem a vivência da experiência do evento, correlacionando tal desfecho à independência financeira e evasão escolar. A técnica de arte terapia possibilitou a reflexão para o exercício saudável da sexualidade na área de estudo.
NKT Agonist-Antigen Conjugates as Cancer Vaccines
Authors: Compton Benjamin J. , Painter Gavin F.
Published: August 2023

Natural killer T (NKT) cells are a population of innate-like T cells capable of enhancing both innate and adaptive immune responses. Co-delivering an NKT cell agonist and antigen can provide molecular signals to antigen-presenting cells, such as dendritic and B cells, that facilitate strong antigen-specific adaptive immune responses. Accordingly, there has been a significant number of developmental NKT cell-dependent vaccine therapies developed, particularly in the last decade, with many incorporating cancer antigens. In this review, we summarize studies that chemically conjugate the NKT cell agonist and antigen as an effective strategy for agonist-antigen co-delivery to drive antitumor responses.
Titanium dioxide-based nanoparticles and their applications in water remediation
Authors: Tiwari Pratibha , Verma Maya , Ambika  , Chutani Hema , Singh Pradeep Pratap , Kanodia Saraswati , Verma Tanushree
Published: August 2023

Water is an essential component of life. Only 2.5% of the total percentage of water available on earth is fresh. As the world’s population is increasing, water pollution is becoming more complex and difficult to remove. Due to change in climatic conditions globally, many regions of the world are facing multiple challenges in sustainable supply of water, and their magnitude is rapidly increasing. Therefore, reuse of waste water is becoming a common necessity. However, due to the presence of water contaminants, such as heavy metals, organic pollutants and many other complex compounds, treatment of contaminated waste water is essential for a healthy life. Nanotechnology offers opportunities to provide efficient, cost-effective and environmentally sustainable solutions for supplying potable water for human use and clean water for agricultural and industrial uses. Photocatalytic processes have shown great potential as a low-cost, environmentally friendly and sustainable treatment technology for water purification. Photocatalytic degradation has been used efficiently for the degradation and removal of toxic and harmful chemicals to improve water quality. Titanium-based semiconductors have been employed as photocatalysts in degradation of organic molecules. In this review, titanium dioxide-based nanoparticles and their applications in water remediation are discussed.
Assessment of Physical activity Level and Sedentary Behaviour Among Pune City Police Personnel Using Global Physical Activity Questionnaire: A Survey
Authors:   Intern, Deccan Education Society’s Brijlal Jindal College of Physiotherapy, Fergusson College Campus, Pune – 411004, Maharashtra, India., Mane Akshata , Berry Aditi Ketkar ,   Assistant Professor, Deccan Education Society’s Brijlal Jindal College of Physiotherapy, Fergusson College Campus, Pune – 411004, Maharashtra, India.
Published: August 2023

Background: Policemen being an integral part of the law implementation system have long working hours with huge workloads. They may not be able to save time for regular exercise or eat timely healthy meals which may put them at high risk of developing non-communicable diseases like cardiovascular diseases, diabetes, or lifestyle disorders such as obesity. The purpose of this study was to assess their existing physical activity level and sedentary behaviour using Global Physical Activity Questionnaire version 2.0. Objective: To assess the level of physical activity in police officers during work, travel and leisure-time and also determine the sedentary behaviour in them. Method: A cross-sectional study was conducted on 270 policemen, 168 males and 102 females, from 16 different police station of the Pune city using Global Physical Activity Questionnaire. Along with the analysis of demographic factors, data was analysed to evaluate if the study participants met the criteria for physical activity recommended by WHO. Participants were then divided into different categories depending on their energy expenditure i.e., MET-mins/week. Their sedentary behavior was calculated in terms of hours spent in sitting position. Result: Out of the total study participants, 50.4% were physically active and 49.6% were physically inactive.3.7% study participants were involved in the moderate-intensity physical activity at the workplace; 32.2% study participants were active in travel domain and 54.8%in leisure-time domain.12.2% of study participants were involved in vigorous-intensity physical activity in leisure-time domain only. 134 participants were inactive, 132 were low-active, 4 were moderately-active with not a single participant in highly-active category. The average amount of time spent sitting in the male participants was 6.11 + 3.03 hours whereas in female participants it was 7.50 + 2.62 hours. Conclusion: Even though 50.4% policemen were physically active, most of them were “low- active” and very few were “moderately-active” whereas not a single study participant was found to be “highly-active”. Sedentary behaviour in terms of average amount of time spent sitting was found to be more in female than male participants. Also,51.11% percentage of the study participants belonged to the overweight and obese category. Thus, there is huge scope for improving the physical activity level as well reducing the sedentary behavior in these professionals. KEY WORDS: GPAQ, physical activity, sedentary behavior, police personnel, Pune city.
Percepción del personal operativo sobre la implementación del Sistema de Gestión de Calidad ISO 9001
Authors: Moncaleano Maquilón Jorge Andrés , Candelo Viáfara Juan Manuel , Rivera Díaz María del Pilar
Published: August 2023

Objetivo: Analizar la percepción del personal involucrado en los procesos operativos sobre la implementación del Sistema de Gestión de la Calidad ISO 9001 en una empresa de servicios públicos para determinar el impacto que esta genera en el desempeño laboral. Método: Investigación mixta que combinó la recolección y análisis de datos cualitativos y cuantitativos, sustentada en entrevistas y encuestas aplicadas al personal con una antigüedad superior a cinco años en la organización. Resultados: Se encontró que el 100% del personal involucrado en el proceso seleccionado, percibe que la implementación del sistema de gestión de calidad, ha generado efectos positivos en ellos como dinamizadores del proceso, siendo la capacitación y la orientación al cliente, los aspectos con mayor impacto, lo que permite inferir  que la implementación de los sistemas de gestión, se relacionan positivamente con el desempeño laboral en las organizaciones. Conclusiones: La percepción del personal operativo con respecto a la implementación de la norma ISO 9001, apoyada en los principios de la gestión de calidad establecidos en ISO 9001, ha generado conciencia sobre el desarrollo adecuado de sus actividades operativas y la orientación al cliente, no obstante, su implementación no es sencilla debido a deficiencia en el liderazgo, la falta de personal capacitado, la baja atención a los riesgos y poco compromiso de la alta dirección para fortalecer el SGC
Factores de la gestión del desempeño y las estrategias de marketing en las pequeñas empresas
Authors: Pimentel Laurens Darianis , Niebles Nuñez Leonardo David , Ramírez Durán Javier
Published: August 2023

Objetivo: Analizar la asociación entre los factores de la gestión del desempeño y las estrategias de marketing en las pequeñas empresas para comprender cómo estas dos variables se asocian dentro del contexto empresarial. Método: Se planteó un estudio cuantitativo, correlacional de campo, en el cual se aplicó una encuesta tipo likert de 61 reactivos en cuatro dimensiones: dos referidas a la gestión del desempeño y las otras dos referidas a estrategias de marketing. Este instrumento se aplicó a una muestra de 94 pequeñas empresas de la ciudad de Barranquilla (Colombia). Resultados: Los hallazgos permiten evidenciar que de las pequeñas empresas encuestadas hay una proporción importante que tienen un desarrollo adecuado de estrategias de marketing y de gestión del desempeño. Ademas, se evidencia un nivel elevado de asociación positiva entre ambas variables. Estos resultados ciertamente demuestran y se contrastan con otros contextos donde las estrategias de marketing se convierten en variables sumamente asociadas (en diversos estudios moderadores) con la gestión del desempeño. Conclusiones: El panorama encontrado dentro de las pequeñas empresas de la ciudad de Barranquilla incluidas en el estudio muestra un nivel representativo de la gestión del desempeño y medio de las estrategias de marketing; realidad debe ser superada para el alcance de una verdadera competitividad dentro del mercado actual al evidenciarse que al mejorar dichas estrategias se lograría una mejor gestión de desempeño.
Climate Change Mitigation At City Level Through The Lens Of South Africa's Regulatory Framework For Bioenergy
Authors: Bezuidenhout Krisdan
Published: August 2023

Climate change is one of the most significant challenges of the 21st century. To combat climate change the international community has agreed to keep the average temperature increase well below 2°C above pre-industrial levels. Despite this consideration, the latest scientific evidence suggests that the planet has already warmed by 1.1°C above pre-industrial levels. The slow reaction by national governments to reducing greenhouse gas emissions has prompted cities to take ownership of climate change mitigation action and drive global intervention from the sub-national level. These urban areas are home to more than half of the world's population and have immense energy requirements, and typically rely heavily on fossil fuels to meet this demand. Therefore, a shift to city level climate governance is significant as cities are both the victims and the culprits of climate change. Should cities supplant fossil fuels with renewable energy initiatives in meeting their energy demands, this would provide a significant boost to climate change mitigation efforts. Bioenergy as a form of renewable energy can potentially contribute to the energy mix in cities through biomass exploitation while simultaneously addressing climate change mitigation efforts. This article focusses on the role of bioenergy in the energy discourse in cities and the potential of law and policy to contribute to developing these biomass-based systems. The article provides insight into the South African bioenergy regulatory framework from an energy and climate change perspective and offers an account of what bioenergy can contribute to cities when considering the transition to a low-carbon economy.
Analysis of forest cover in Parque Nacional Tingo María (Peru) using the random forest algorithm
Authors: Puerta Ronald , Iannacone José
Published: August 2023

The establishment of natural protected areas is one of the most effective strategies to conserve forests and their biodiversity; however, the uncontrolled advance of deforestation resulting from the change of use to expand the agricultural frontier has become a threat to these intangible areas. This research aimed to analyze the dynamics of forest cover in Parque Nacional Tingo María (PNTM) and its buffer zone (ZA) located in the high jungle of the Huánuco region of Peru. The main input was Sentinel-2 images that were classified using the Random Forest algorithm. As a result, coverage maps were obtained for the study area corresponding to the years 2017, 2019, 2021 and 2023, achieving considerable thematic accuracy. During the evaluation periods, the rates of change from forest to non-forest within the PNTM presented low values -0.26% (2017 - 2019); -1.24% (2019 - 2021) and -0.02% (2021 - 2023). While the forests in the ZA have undergone a dynamic transition, with rates of change of -2.97%; -4.39% and -1.15% derived from land use change. The landscape metrics suggest that the forests of the PNTM are moderately fragmented, and the forests of the ZA are strongly fragmented, which leads to the conclusion that the protected natural area has fulfilled its objective of maintaining vegetation cover.
Effect of heat processing on bioactive compounds of dehydrated (lyophilized) purple mashua (Tropaeolum tuberosum)
Authors: Medina Marroquin Luis Alberto , Yucra-Condori Harry Ricardo , Gárate José , Mendoza Cecilia , Deflorio Enrique
Published: August 2023

Mashua (Tropaeolum tuberosum) is an Andean tuber rich in phenolic compounds and glucosinolates, known for its consumption that allows the prevention and/or reduction of getting diseases. The present research evaluated the effect of different types of post-harvest management (sunny, bleached, and freeze-dried) on glucosinolate content and its relationship with myrosinase activity. It is also important to note that when plant cells are damaged and glucosinolates meet the plant's myrosinase, which hydrolyzes them and degrades them to other compounds. In the present research, the types of glucosinolates, the content of glucosinolates and the activity of myrosinase of the purple variety of fresh raw mashua and in mashua treated by several types of processing were evaluated, including the previous treatment (sunny and unscrewed), the boiling treatment and the microwave treatment, with whitening times of 3, 4, 5 and 6 minutes, being the condition of the tuber at the time of bleaching in whole form and by cutting, to then be subsequently subjected to lyophilization treatments. Five glucosinolatos (GSL) were identified: 5-methylsulfinilpentile, 4-hydroxybenzyl, 4-hydroxy-3-indolylmethyl, benzyl and 4-methoxybenzyl, of which 4-methoxybenzyl glucosinolate is the most abundant, symbolizing 98% and 95% of the total GSL in the purple ecotype. According to the total concentration of glucosinolates found in the studied variety (purple), it must be 74.22 and 110.60 micromoles per gram of dry base (μmol/g dry weight), so mashua can be considered, the edible plant with the highest existing GSL content.
Dinamik parti büyüklüğü belirleme ve çizelgeleme problemi için bir matsezgisel geliştirilmesi ve uygulaması
Authors: KUBUR ÖZBEL Burcu , BAYKASOĞLU Adil
Published: August 2023

Geleneksel kısıtlandırılmış parti büyüklüğü belirleme problemi işletmelerde sıklıkla karşılaşılan problemlerden biridir. Ancak, bu problemlerin modellenme aşamasında gerçek hayatta geçerli olabilen pek çok faktör dikkate alınmamaktadır. Bu çalışmada, sipariş üzerine kağıt/karton çanta üretimi yapan bir işletmedeki bütünleşik parti büyüklüğü belirleme ve çizelgeleme problemi modellenerek çözümlenmiştir. Problem için karışık tam sayılı programlama modeli önerilmiştir. Önerilen modelde, ürünler arası geçişlerde ve üretim periyotlarındaki hazırlık süreleri ve maliyetleri göz önünde bulundurulmuştur. Geliştirilen model, üretim maliyeti, elde tutma maliyeti, karşılanamayan talep maliyeti, dışardan satın alma maliyeti ve sıra bağımlı ürün geçişlerinin hazırlık maliyeti toplamını en küçüklemeyi hedeflemektedir. Geliştirilen modelin uygulamasıyla, üretim kaynaklarının daha verimli kullanılıp daha efektif üretim planlarının ortaya konulabileceği görülmüştür.
A Histopathological Study of the Therapeutic Role of Kisspeptin-10 Against Cadmium Chloride Toxicity in Rats
Authors: Alaqbi Saif , Abed Bassam Ali , Al-Sharafi Nabeel M.N.
Published: August 2023

Kisspeptin is originally a metastasis suppressor. Currently, post preliminary discovery, the crucial physiology of kisspeptin appeared among several biological function in the living body such as supporting the reproductive system, regulation the metabolism, improvement the cardiac muscle action and smooth muscle of blood vessels. Moreover, Kisspeptin play an important role as a neurotransmitter through the Kisspeptin receptor. This study is designed to examine the anti-toxic role of Kisspeptin in some vital organs including the liver, spleen, and kidney. Kisspeptin is demonstrated as a detoxification agent via the elimination of toxicity of cadmium chloride to some organs of living rats such as the liver, spleen, and kidney. Direct negative effects of Kisspeptin on these organs have only been recognized. This study attempts to explain this role during the examination of histopathological changes in the case of cadmium chloride toxicity and the effect of Kisspeptin in reducing or elevating the toxicity after its administration in both 20 and 40 nanomolar / animal doses. Arguments and recent boundaries in the field, as well as areas of coming research related to kisspeptin’s varied function array, should underline.
A Macroscopic and Microscopic Study of Liver in Female Iraqi Green Freshwater Turtle (Chelonia mydas) Linnaeus,1758 during the Active Period
Authors: Al-Alwany Ekhlas Abid Hamza , Al-Khakani Salim Salih Ali , Al-Khamas Ahlam J. H. , Al-Janabi Sabreen M. , Zabiba Isam M J , AL-Khafaji Siraj M.
Published: August 2023

The study aims to provide anatomical and histological information about the liver in female Iraqi green freshwater turtles. Ten female green freshwater turtles (Chelonia mydas) were collected from Shatt Al-Hilla and used in this study. They were anesthetized by chloroform in closed chambers. The anatomical information was recorded and the histological sections of the liver were stained by using hematoxylin and Eosin stains. The result showed that the liver of a female green freshwater turtle (Chelonia mydas) is a large elongated organ. The mean weight of turtles is 735±0.04 gm, and the mean weight of the liver is 28±0.02 gm. The ratio between the weight of the liver to the weight of the body was 3.809 %. The liver of (Chelonia mydas) is formed from three lobes right, left and middle (central) lobes. The right lobe is the large one with an average weight of 13 ±0.022 gm.  It looks like a square and has two surfaces ventral and dorsal (visceral) surface. The left lobe is smaller than the right with an average weight of 9±0.05gm, and its shape is rectangular. The middle lobe is rounded and small. Its mean weight is 7±0.01gm. Histologically, the liver is covered by mesothelium under its connective tissue layer as a hepatic capsule which divided the liver into lobules in the shape of hexagons with portal spaces, from the central to the walls of the hepatocyte.