bluuebunny/crossref_metadata_2025 huggingface dataset:
Causes and Surgical Outcome of Orbital Wall Fractures in Mongolia
Authors: Bold Uyen , Erz Sanjaa , Sanjaa Udval , Khadbaatar Ulziijargal , Bat-Erdene Undraa
Published: November 2022

Objective: To determine causes, clinical manifestations of orbital wall blowout fractures, and evaluate surgical outcomes. Methods: A retrospective study with repeated measurements was conducted in 194 cases with orbital reconstructive surgery between 2002 and 2017 at Orbita Eye Hospital. The analyzed variables were patient age, sex, causes, and clinical manifestation of orbital wall fractures. Surgical outcomes, implant dependent, and surgical approach complications were prospectively analyzed in 60 patients up to 24 months after the initial surgery. Results: Orbital wall fractures were caused by assault in 82.7% of cases, household accidents 9.9%, car accidents 7.4%, and 0% by a sports injury. Diplopia was noted in 16.7%, extraocular movement limitation in 16.7%, enophthalmos in 23.3% for 24 months, or and more following surgery. In 4.2% of cases, prolapse of the orbital fat was noted using the transconjunctival approach, and 16.6% eyelid retraction with scarring in the subciliary approach. Implant displacement was noted 6.6% of cases in which a silicone sheet was used to reconstruct the fracture defect. Conclusions: Assault was the leading cause of orbital fractures, and this most often occurred in young males in Mongolia. Common signs and symptoms of orbital fractures were enophthalmos, diplopia, and extraocular movement limitation. The range of post-surgical enophthalmos, diplopia, and implant-related complications was consistent with those reported by other studies.
Sclerosing Angiomatoid Nodular Transformation of the Spleen: A Case Report
Authors: Lkhagvadorj Sayamaa , Urjin Sanchin , Erdenebaatar Usukhbayar , Bat-Erdene Batsaikhan
Published: November 2022

Objectives: Sclerosing Angiomatoid Nodular Transformation (SANT) of the spleen is a rare benign vascular lesion with unknown etiology. Our purpose is to present our experience with this condition and review the available literature regarding it. Methods: This report depicts a pathologically proven case of SANT in a 32-year-old man with a history of two previous old injuries who presented with weight loss, vomiting and with left upper quadrant pain and an enlarged spleen. Results: The patient was successfully treated by splenectomy and diagnosed with SANT based on histological and immunohistochemical findings postoperatively. Conclusion: Most patients with SANT are asymptomatic. Imaging studies are essential for detection and the management of SANT. However, the final diagnosis can only be made by histopathology. SANT does not recur after splenectomy.
Buteelch-5, A Traditional Formula Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice
Authors: Hasiqiqige  , Zhang Fanfan , Dalkh Tserendagva , Sharav Bold , Perenlei Molor-Erdene
Published: November 2022

Objectives: To examine the therapeutic effects of buteelch-5, a traditional formula on DSS-induced colitis in C57/BL6 mice and its possible mechanisms. Methods: Colitis in mice was induced by oral administration of 5% dextran sulfate sodium (DSS) for seven days. On the eighth day after administration of DSS, buteelch-5 (500 mg/kg, twice a day) was given orally to mice for five consecutive days. Ciprofioxacin (50 mg/kg, once a day for 5 days) was given to mice as a comparison. Two hours after the last administration of buteelch-5 and ciprofioxacin, mice were euthanized, and colon tissues were removed. Protein and mRNA levels of occludin, claudin-1 and zonula occludens (ZO)-1 in colon tissues were determined by western blot and real time-qPCR respectively. Histopathological analysis of colon tissues was performed. Results: Histological analysis revealed successful establishments of colitis models. Treatment with buteelch-5 markedly inhibited DSS-induced colon injury. Furthermore, buteelch-5 increased (2.14-2.67 fold) the occludin, claudin and ZO-1 protein and mRNA levels in colon tissues of mice administered with DSS. Significant increase was observed in occludin mRNA levels after buteelch-5 treatment (p<.05). Conclusion: Buteelch-5 improves microscopic inflammation and increases tight junction protein expressions such as occludin, claudin, and ZO-1 in mice with DSS-induced colitis.
DIFFICULTIES OF SPEAKING THAT ARE ENCOUNTERED BY ENGLISH LANGUAGE STUDENTS AT AL MARGEB UNIVERSITY
Authors: Dalem Mohamed
Published: November 2022

The aim of this paper is to explore the speaking difficulties encountered by English language students at Al Margeb University, and to discover the causes of such difficulties. Speaking English has been a vital importance in international communication. Speaking fluent English is a common problem among the nonnative speakers. The second language learners have gone through a variety of cases to learn how to speak not only correct grammar and using the right vocabulary but with correct accent and pronunciation. Many obstacles, therefore, have been known as the predictors of such a problem among the language learners.  According to the review of literature, appropriate speaking instruction was found to be the learners' priority and a field in which they need more attention. In this paper the writer highlight the speaking difficulties encountered by English language students at Al Margeb University, which are considered to be the most urgent for every teacher, such as fear of mistakes, shyness, anxiety, lack of confidence and lack of motivation. This paper can be useful to teachers to consider their language learners' speaking needs in English language teaching and learning context.
RETHINKING ACADEMIC ESSAY WRITING: SELECTED GENRES IN COMPARISON
Authors: Turmudi Dedi
Published: November 2022

How do opinion, discussion, and argumentative convince readers? How does each of them look different from each other seen from the generic structure, and language use? This conceptual paper is exploring how three selected genres in academic writing differ from each other. By reviewing journals of related topic of recently published, the writer convinces that opinion genre is less strong in persuading readers, and argumentative is very strong in assuring readers, whereas discussion is neutral in affecting readers The implication is that each genre has its own place to make readers satisfied and each of which indicates the level of ego and sophisticated countering back the statement called rebuttal and arguments and example. By reading this article readers will detect the tone of each genre and to what extent does each genre reach the readers’ mind. The implication is that any teacher or lecturer is best recommended to present this model, particularly in EFL context.
Game theoretic model for low carbon supply chain under carbon emissions reduction sensitive random demand
Authors: Ma Chao , Huang Fuyou , Hu Yongwen
Published: November 2022

This paper considers a low carbon supply chain consisting of a single manufacturer and a single retailer under the condition that the demand is uncertain. We first establish three games, including manufacturer Stackelberg (MS), retailer Stackelberg (RS) and Nash according to the different power structure of the firms. We then determine that the equilibrium stocking factors, emission reduction levels, wholesale prices and retail prices for the three models, respectively. After that, we demonstrate the effects of power structure. Results show that when the power shifts from the retailer to the manufacturer, the stocking factor decreases, whereas the wholesale price increases. Finally, we discuss the impacts of the random demand. We find that the expected profits of the firms, the emission reduction levels and the retail prices are increasing with respect to the market potential and low-carbon sensitivity coefficient, respectively. Meanwhile, they decrease with respect to the price sensitivity coefficient.
Impact Assessment of the Renewable Energy Policy Scenarios – a Case Study of Latvia
Authors: Kacare Marika , Pakere Ieva , Gravelsins Armands , Blumberga Andra
Published: November 2022

Even though the development of renewable energy technologies has been one of the most discussed and research-rich fields of science, and there are many practical and convincing technologies in the field of renewable energy, the path taken by society to shift from the use of non-renewable energy sources to the use of renewable ones has often been slow and unclear. Renewable energy technologies have undergone many improvements. There are several successful and promising examples where installing renewable energy technologies has paid off financially and improved the environment and quality of life. Nevertheless, fossil fuel still dominates or makes up a large proportion of energy production. The research simulates existing, planned, and potential policies to assess the best way to integrate renewable and local energy resources into the energy system by 2030 and in the long term. Policy analysis is carried out for several possible combinations of support measures to assess if it is possible to achieve the set targets in the National and Climate plan by 2030 and reach Climate neutrality by 2050. Such an approach makes it possible to assess the impact of existing policies that create synergies or undesirable side effects and whether they maximize the return on investment from a socio-economic and environmental point of view. In addition, a risk analysis and impact assessment of the proposed policy scenarios are carried out using multi-criteria analysis.
First students graduated from the Women’s Medical Institute (to the 120th anniversary of the event)
Authors: Zhuravlyov A. A.
Published: November 2022

The article describes the history of the first students enrolled and graduated from the St. Petersburg Women’s Medical Institute. The article describes how public organizations and various individuals helped women receive higher medical education. How Russian public reacted to the first graduation of students of the Institute. The fate of two graduates of 1902 is presented, based upon archival materials.
Endothelial dysfunction in patients with various forms of congenital epidermolysis bullosa
Authors: Kornev V. I. , Startseva O. N. , Pleshkov A. S. , Nikiforov M. V.
Published: November 2022

Introduction. The endothelial system is an important component of vascular-platelet hemostasis, capable of actively responding to mechanical and inflammatory agents. Patients with congenital epidermolysis bullosa are prone to mechanical damage to the skin and the development of a chronic inflammatory syndrome with a high probability of endothelial dysfunction.

The study objectivewas to assess the state of the endothelial system and to reveal the dependence of endothelial dysfunction on the form of epidermolysis bullosa.

Methods and materials. The study used venous blood of 57 patients (27 men and 30 women) with congenital epidermolysis bullosa. In patients with simple and dystrophic forms of epidermolysis bullosa, the platelet count, P-selectin, fibrinogen, albumin, C-reactive protein, von Willebrand factor antigen concentration, and factor VIII activity were determined.

Results. Comparative results of endothelial dysfunction depending on the form of epidermolysis bullosa were represented and endothelial dysfunction’s dependence on the concentration of albumin, C-reactive protein, and platelet count was determined.

Conclusions. In patients with a dystrophic form of epidermolysis bullosa, endothelial dysfunction is accompanied by an increase in the expression of P-selectin, factor VIII activity, and the concentration of von Willebrand factor antigen. Chronic inflammation and impaired nutritional status with a decrease in albumin contribute to the development of endothelial dysfunction.
Systemic inflammation in salivary gland cancer
Authors: Kutukova S. I. , Belyak N. P. , Ivaskova J. V. , Razumova A. Ya. , Pakhomova N. V. , Frolov N. A.
Published: November 2022

Relevance. The inflammatory process and endogenous intoxication of the patient’s body has a negative impact on the course of many malignant neoplasms, including salivary gland cancer.

The objective of the study was to determine the influence of some factors of systemic inflammation and endogenous intoxication in salivary gland cancer.

Methods and materials. A prospective study included the data of 59 patients with salivary gland cancer. The influence of peripheral blood parameters and relative indicators characterizing systemic inflammation on overall and disease-free survival was assessed.

Results. As a result of the multivariate analysis, it was revealed that an increase in the level of the relative number of peripheral blood neutrophils by more than 60.08 % increases the risk of death in patients from salivary gland cancer by 3.90 times (p=0.0456; HR 3.90: 95 % CI 1.03–14.79). The level of the absolute number of peripheral blood lymphocytes, not exceeding 1.49x109 /l, increases the risk of disease progression by 8.72 times (p=0.0002, R 8.72: 95 % CI 2.78–27.28).

Conclusion. Individual factors of systemic inflammation and endogenous intoxication, it is advisable to evaluate at the stage of planning the primary treatment of patients with salivary gland cancer, in order to determine the prognosis of the disease and optimize the choice of tactics for the primary treatment of patients.
Vosoritide: a drug providing a promising avenue for the treatment of short stature in children with achondroplasia
Authors: Qureshi Amsal , Alvi Areesha
Published: November 2022

Not available
“I thought asking the experts of the board first before turning at the unctuous salesmen.” Requesting special field related advice and information on online communities
Authors: Salmela Eveliina
Published: November 2022

This study focuses on requesting and sharing specialized information on online communities. The aim was to find out how requesting and receiving special field related information function on online discussions about heat pumps in Finland. The data consists of 300 message threads collected from two Finnish discussion boards, Lampopumput.info (heatpumps.info) and Suomi24.fi (Finland24.fi). The data was analyzed using discourse analytic methods and pragmatic concepts such as speech acts, politeness, relevance and humor. The results demonstrate the sense of community as an important part of the specialized communication in online peer support discussions. The appropriate wording of the messages, politeness and giving one’s personal contribution to the community are important factors in conveying information through online communities. Online peer discussions have several different communicative goals, such as requesting and offering technical support, requesting advice, sharing experiences and expressing views and opinions. Users use different platforms to carry out these goals. Requesting advice and sharing information were emphasized on the discussion board that requires registration from the contributors. The discussion board, which required registration, was more specific to the topic and community like. There were more direct answers and dialog between the users than on the anonymous discussion board. On the open discussion board, which did not require registration, writers expressed more their own personal views and opinions and discussed especially about topics related to the purchase situation.
Keywords: Asynchronous online discussion, online communities, technical communication, peer advice, requesting advice
Confiscation Of Assets For The Crime Corruption Used As Guarantee Mortgage
Authors: Yatmoko Tri
Published: November 2022

Asset confiscation is one of the government's efforts to compensate for state losses. The Prosecutor's Office is one institution with the authority to carry out asset confiscation based on court decisions. In carrying out judicial decisions on corruption crimes, the Prosecutor's Office experiences various obstacles in practicing the value of justice, one of which is the seizure of assets attached to mortgages. The assessment of confiscating assets burdened with mortgages uses empirical juridical methods through library research and field research. The problem of this research focused on the practice of confiscating assets resulting from corruption in recovering state finances and how is the mechanism for confiscating assets resulting from corruption with mortgages attached. The study results show that in practice, the seizure of assets resulting from corrupt criminal acts takes a very long time because the time required for a case to obtain a binding court decision can take months, maybe even years. Next, the mechanism for confiscation of assets by prosecutors can confiscate assets resulting from corruption crimes that are pledged in the bank with mortgage rights attached, as long as the court can prove that the assets are indeed the result of corruption crimes and have permanent legal force (Eintracht). Because the criminal law position (public) is higher than civil law (private).
Implementation Of The Death Criminal Sanction In The Corruption Criminal Action Law
Authors: Putra Muhammad Tetuko Nadigo
Published: November 2022

Criminal act of corruption which is governed under, subsequent called UUTPK is not yet set assertive regarding the amount and related conditions with inner country state as specific stated under Article 2 Paragraph (2) UUTPK which states: that in case act criminal corruption like as referred to in paragraph (1) is carried out in situation-specific, then criminal dead could implement. The method study used in this paper are juridical normative and empirical. Approach the study was conducted at the Tanjung Karang District Court, Bandar Lampung District Attorney, Peradi Lampung DPC, and Lampung University. Type of data used is secondary data and primary data. The results of research and discussion show that death criminal sanction not applied in acts of criminal corruption as set is in UUTPK. Regulation Number 20 of 2001 contained in Article 2 paragraph (2) is inefficient because in its implementation the judge often decides to use Article 2 paragraph (1) UUTPK in case of criminal corruption because provision chapter clearly explains the terms and the conditions of the quert article. This provision chapter could be applied, and P 2 paragraph (2) the original has much weakness because Article 2 paragraph (2) do not explain the apparent size and terms subjugated on somebody for convicted death sanction according to the author. If Article being (2) paragraph 2 wants to be applied, it must be clarified in the chapter/provision. For example, if corruption or loss of state money is above Rp. 1 billion, the convict must be punished dead. The reason as to why death criminal sunction is not applied effectively wittin corruption criminal act , has also something to do with the willingness of Indonesian judges to conviet perpetraturs with maximum punishment, of course in the and such legal decision must also be seen from varius aspects
Toxicity of Agave sisalana extracts on Cordyceps and their effect and the association with fungi on Nasutitermes corniger (Isoptera: Termitidae)
Authors: Da Silva Lopes Rosineide , Barroso Martins Mônica Cristina , De Lima Geiziquele , Gonçalves de Oliveira Luciana , Félix da Costa Antonio , Dos Santos Venézio Felipe , Dos Santos Correia Maria Tereza , Da Silva Nicácio Henrique , Correia de Albuquerque Auristela , Áurea de Luna Alves Lima Elza , De Menezes Lima Vera Lúcia
Published: November 2022

Nasutitermes corniger is an arboreal termite that causes economic damage in urban areas, and its control is for chemical insecticides. An alternative for insect control is the use of entomopathogenic fungi and plant extracts, or the synergistic effect of the association of these. The toxicity of aqueous and hydroethanolic extracts of Agave sisalana on the biological aspects of the fungal Cordyceps  farinosa, C. fumosorosea and C. javanica and the action of the extracts and their synergistic effect on N. corniger was examined. The effect of the extracts on fungi was evaluated by germination, sporulation and mycelial growth of fungi in Sabouraud medium through the study of biological aspects under laboratory conditions; and control of N. corniger were examined, by ingestion of extracts and of the association extract plus fungus on filter paper, being the percentage of mortality of soldiers and workers of the termite daily. In general, the extracts were inoffensive to the fungi at concentrations 10, 25, 50, 100 and 200 mg.mL-1. The extracts demonstrated termiticidal actions at concentrations tested, causing the mortalities about 100% of the workers after the third and sixth days (LC50: 0.778 to 0.803 mg.mL-1) and 100% of the soldiers between the fourth and seventh days (LC50:0.146 to 0.956 mg.mL-1). The association of the extracts with C. farinosa ESALQ1355 was more efficient in inducing the mortality in N. corniger. These results demonstrated the efficiency in vitro of the sisal extracts in controlling N. corniger termites, alone or in combination with fungi, suggesting their potential joint usefulness in the biological control of insect pests.
التمثيل الخرائطي لتوزيع الامطار في الإقليم الجبلي من العراق
Authors: Muhaimid Farhan Faaq Hassan
Published: November 2022

تشكل خرائط الأمطار إحدى الطرق الكارتوكرافية التي توضح الظواهر الجغرافية التي تتعرض تذبذبها وانسيابها من مكان الى أخر، وقد أكدت الدراسة على محاور عدة منها ماهي خطوط المطر المتساوية، وخطوات إنشائها، ومشاكلها الفنية، وتطبيقاتها. تعد الخرائط التي تمثل حالات الرياح والعواصف والأعاصير المضادة وما إلى ذلك مهمة جدًا. لتتمكن من التنبؤ بالطقس. وخرائط الطقس ليست أكثر من تمثيلات بيانية تساعدنا على معرفة القيم التي تمتلكها بعض متغيرات الأرصاد الجوية في منطقة جغرافية معينة. من بين جميع خبراء الأرصاد الجوية، يستفيدون من هذه الخرائط، حيث يوفر استخدامها الكثير من المعرفة وصورة مثيرة للاهتمام حول جميع المواقف التي يمكن أن نجدها في الغلاف الجوي.
وبما ان السمة التي اتضحت بشكل واضح في الابحاث الجغرافية المعاصرة اليوم هي توظيف التقنيات الحديثة في الدراسات الجغرافية التطبيقية لاسيما في مجال خرائط الطقس والمناخ التي تعد فرعاً حديثاً في الجغرافيا. فقد تم توظيف نظم المعلومات الجغرافية (GIS) من خلال برنامج (ArcMap10.8) وهو احد برامج هذه التقنية والذي يمتاز بخصائص التحليل المكاني ورسم الخرائط الموضوعية. لما يتمتع به البرنامج من ادوات الرسم الالي للخرائط للرموز الخطية والنقطية والمساحية. وتمثلت مشكلة البحث هل يمكن بناء خرائط كميات الامطار اعتمادا على الموقع الاحداثي للمحطات المناخية توضح فيها كميات وتباين تساقط الامطار لفترات معينة. وكانت النتائج في رسم خرائط لتساقط المطري ذات إمكانية عالية في الادراك اضاقة الى تصميم قواعد بينات للمحطات المناخية قابلة للتحديث.
Indian blackberry (Syzigium cumini L.) nectar processed without chemical preservatives-changes in physico-chemical properties and bioactive constituents during storage-siftdesk
Authors:   Kerala Agricultural University, Gomez Saji , Kuruvila Bintu , P.K Maneesha , Joseph Meagle
Published: November 2022

Indian blackberry fruit is widely acclaimed for the antidiabetic property. The fruits are highly perishable, having a shelf life of about two days. Therefore, an attempt was made to convert the fruits into nectar by pasteurization, without adding any chemical preservatives. Indian blackberry nectar having a total soluble solids content of 17 0 Brix and acidity of 0.253% without any chemical preservatives, was pasteurized at 100 0 C, for 10 minutes. Viscosity of the nectar recorded an upward trend throughout storage, irrespective of storage temperature. The L* and b* values rose with a corresponding decline of a* values during storage of the product. Pasteurized Indian blackberry nectar had an initial vitamin C content of 18.6 mg 100g- 1. After three months of storage, total phenolics in Indian blackberry nectar were 59.50 and 57.50 mg 100g-1 under ambient and refrigerated storage, respectively. The product held under refrigerated conditions had significantly higher anthocyanins (85.67 mg) than the nectar held at ambient temperature (78.72 mg 100g-1). Scavenging of DPPH radical of the nectar declined slightly (2.94 µg ml-1), compared to that in fresh fruits (2.75 µg ml-1).
DETERMINATION OF PROBABLE CORRUPTION RISKS DURING THE APPLICATION OF THE ARMED FORCES OF UKRAINE
Authors:   National University Defense of Ukraine named after Ivan Chernyakhovsky, Honcharuk Dmytro , Kalitnyk Maksym ,   National University Defense of Ukraine named after Ivan Chernyakhovsky, Pikul Rostyslav ,   National University Defense of Ukraine named after Ivan Chernyakhovsky
Published: November 2022

Among the main processes of modern social development, the majority of scientists single out globalization. Ukraine, as one of the largest European states with great economic and geopolitical potential, cannot remain aloof from world trends. However, public managers, politicians and scientists need to remember the numerous obstacles that inevitably accompany such important phenomena for society. And perhaps the most dangerous threat to the development of society today is corruption. Today, there is no country where corruption has been completely eradicated. None of the socio-political and economic systems had, does not have, and cannot have complete immunity to corruption. Corruption can exist for a long time even in developed democratic countries and in countries with an open market economy. The difference is not in the presence or absence of corruption as such, but in its scale, nature of corruption manifestations, influence on economic, social, political, legal and other processes. On the one hand, corruption characterizes the main social relations carried out in the state and society, on the other - it affects the economy, politics, law, ideology, social psychology, etc. Corruption manifests itself in the ineffectiveness of the government, the imperfection of the most important state and social institutions. Thus, presiding over a meeting of the National AntiCorruption Committee, the President of Ukraine emphasized: "The fight against corruption is a vital matter for society, as this phenomenon threatens national security and the constitutional order in Ukraine." Ukraine belongs to the countries with war zones, which are characterized by an increase in the level of corruption. It is necessary to understand that corruption is a key threat to the national security of the state, at the same time it has a synergistic effect on all other threats in the field of security, contributing to the activities of various forms of organized crime, increasing social instability, which deprives the state of the ability to perform the functions assigned to it by society, hindering development economy.
CRYSTALLINITY DEGREE OF A POLYMERIC MATRIX OF MICRO- AND NANOCOMPOSITES BASED ON POLYAMIDE 6
Authors:   Institute of Engineering Thermophysics of NAS of Ukraine, Fialko Nataliia , Dinzhos Roman ,   V.О. Sukhomlynskyi National University of Mykolaiv, Sherenkovskiy Julii ,   Institute of Engineering Thermophysics of NAS of Ukraine, Meranova Nataliia ,   Institute of Engineering Thermophysics of NAS of Ukraine, Fedosenko Leonid ,   Institute of Engineering Thermophysics of NAS of Ukraine, Yurchuk Volodymyr ,   Institute of Engineering Thermophysics of NAS of Ukraine, Kutnyak Olha ,   Institute of Engineering Thermophysics of NAS of Ukraine, Popruzhuk Illia ,   Institute of Engineering Thermophysics of NAS of Ukraine, Klishch Andriy ,   Institute of Engineering Thermophysics of NAS of Ukraine, Khmil Dmytro ,   Institute of Engineering Thermophysics of NAS of Ukraine
Published: November 2022

A relationship between the thermal conductivity properties of polymeric micro- and nanocomposites based on polyamide 6 and the degree of crystallinity of the polymer matrix has been revealed. It is shown that a decrease in the degree of crystallinity leads to an increase in the thermal conductivity of the composites. It has been established that a higher content of fillers corresponds to lower values of the degree of crystallinity of the matrix.
FORMATION OF THE MODEL FOR PROVIDING INFORMATION PROTECTION AT THE ENTERPRISE
Authors:   Ivano-Frankivsk National Technical University of Oil and Gas, Polyanska Alla , Diuk Oksana ,   Ivano-Frankivsk National Technical University of Oil and Gas
Published: November 2022

Information security of an enterprise is a functional element of the system for ensuring its strategic development. Its main task is to ensure the stability of the enterprise's existence in the present and the prospects for its sustainable development in the future. The integrated system for ensuring the information security of enterprises takes into account modern legal and organizational and managerial measures, as well as software and hardware tools for countering external and internal threats, which ensures the state of information security and the prospects for the development of information technologies. The organizational level of information protection includes organizational regulation, organizational regulation and organizational instruction and ensures the organization of security, regime, work with personnel, with documents, standards for the use of technical security means and procedures for information and analytical activities of the enterprise to identify threats. The organizational aspect of ensuring the information security of an enterprise is one of its most important elements, since the effectiveness of all activities to support the information security system at the proper level largely depends on the actions taken for implementation. The main task is to characterize the information security system at the enterprise. The research of the information security system at the enterprise was carried out. It has been determined that the correct solution to the issue of creating information security bodies will help accelerate the integrated implementation and maintenance of an integral information security system, coordinate legal, administrative, organizational, technological, scientific, technical and physical measures to protect information. It is given that information security programs should take into account how an organization and its people, processes and technologies interact; and how organizational governance, culture, human factors, and architecture support or hinder an enterprise's ability to protect information and manage risk. It is highlighted that information security managers should do their best to create programs that meet the goals and priorities of the enterprise, benefit the enterprise and support the ability of management to innovate while controlling risks.
Criminal Competition: Spheres, Analysis and Counteraction in Public Administration
Authors: Стецюнич Юлия Николаевна , Зайцев Андрей Александрович
Published: November 2022

Криминальная конкуренция - это элемент рыночных отношений, развитие которого представляет интерес для правоохранительных органов, поскольку оказывает отрицательное влияние на экономику в целом. В статье рассмотрена сущность понятия «криминальная конкуренция», выявлены отличия криминальной конкуренции от экономической (добросовестной) конкуренции, рассмотрены основные причины развития криминальной конкуренции в отечественной экономике, проанализированы статистические данные о составе преступлений в экономической сфере по причине криминальной конкуренции, в том числе в отдельных сферах деятельности, изучены действующие и предложены направления борьбы с недобросовестной конкуренцией в рамках государственного управления.

Criminal competition is an element of market relations representing interest to law enforcement agencies due to its negative impact on the economy as a whole. We consider the essence of criminal competition, identify its differences from economic (fair) competition and look at the main reasons for the development of criminal competition in the domestic economy. We also analyze the statistics concerning corpus delicti in economic sphere resulting from criminal competition in various areas of activity, make a research of current measures of unfair competition counteraction and suggest new ways of struggle against it within public administration.
Objectives, Purposes and Instruments of Implementation of «Science» National Project
Authors: Горчаков Сергей Евгеньевич
Published: November 2022

В статье анализируются перспективы реализации национального проекта «Наука». Описываются ключевые цели проекта для научного и технологического обеспечения реализации задач и национальных приоритетов Российской Федерации, разработанных в рамках целеполагания на федеральном уровне и определенных в документах стратегического планирования. Подчеркнуто значение эффективной работы функциональной структуры в ходе инициирования, подготовки, реализации и завершения федеральных и региональных проектов и государственных программ. Обоснована необходимость совершенствования подходов в управлении реализацией национального проекта «Наука».

The article focuses on the prospects of implementation of «Science» national project. Particular attention is drawn to describing the key objectives of the project for the scientific and technological support aimed to ensure fulfillment of the aims and objectives of national priority which are developed within a goal setting framework at the federal level and which are defined in the relevant documents of strategic planning. The importance of efficient performance of functional structure is highlighted with regard to the processes of initiating, planning, implementing and completing the federal and regional projects along with government programs. The author substantiates the need for improving approaches and methods of «Science» national project management.
Adipsin – summing up large-scale results: A review
Authors: Salukhov Vladimir V. , Lopatin Yaroslav R. , Minakov Alexey A.
Published: November 2022

Adipsin is one of the first discovered adipokines hormones produced by adipose tissue. Adipsin performs the function of a regulator of carbohydrate and lipid metabolism and participates in the adaptation of metabolism to the real needs of the body, being a powerful stimulant of anabolic processes. A characteristic feature of adipsin is that it is also a complement factor D, which is necessary for the normal functioning of an alternative pathway of activation of the complement system. Due to this, adipsin is represented in the body as a link between the energy block of the endocrine system and the humoral block of the immune system. Adipsin is known as a regulator of the function of pancreatic beta cells, a stimulator of lipogenesis, a modulator of inflammation processes. Recently, there have been works indicating the effect of adipsin on the microbiota, as well as its role in non-alcoholic fatty liver disease. To date, there are a large number of publications describing the biochemical structure, functions of adipsin, mechanisms of regulation of its synthesis, as well as changes in the level of adipsin in various pathological conditions. Attempts are also described to pharmacologically influence adipsin in order to modulate its functions or use it as a biomarker for the diagnosis of diseases. However, there is currently no structured review that summarizes and systematizes all available information about this adipokine. This is exactly the task we set ourselves in this study. The paper contains the results of all available studies on adipsin. In some cases, they are contradictory in nature, which indicates the need for further research in detecting connections between the body's systems.
Somatic mutations in colorectal cancer: regional experience
Authors: Ognerubov Nikolai A. , Ezhova Elena N.
Published: November 2022

Introduction. Colorectal cancer is one of the most common malignant neoplasms in economically developed countries, ranking 3rd and 2nd in the structure of morbidity and mortality, respectively. Current knowledge about the molecular features of colorectal cancer is necessary to implement the principle of personalized therapy.
Aim. To study regional features of tumor genomic landscape in colorectal cancer.
Materials and methods. The retrospective study from 2019 to 2022 included 153 patients with stage IIV colorectal cancer aged 32 to 80 years, with a median of 63.8 years. DNA samples extracted from paraffin blocks of tumor tissue were analyzed using a real-time polymerase chain reaction. The study patients included 43.8% of males and 56.2% of females.
Results. Somatic mutations were detected in 48.4% of patients. The maximum number of mutations was detected in the KRAS gene 60 (81%). The mutation rate was significantly higher in females versus males. KRAS mutations predominate in the colon compared to the rectum, accounting for 66.7 and 33.3%, respectively. In tumors of the right colon, these mutations were detected in 18.3% of cases, and in the left colon, 48.4%. NRAS mutations were found in 9.5% of cases, mainly in tumors of the left colon. BRAF mutations were diagnosed in 6 patients, 5 of them were women, and the tumors were localized in the right colon. The highest rate of KRAS mutations was observed in codons 12 and 13, accounting for 86.7% of cases. The G12V mutation occurred in the majority of patients (25%), followed by G12D (20%) and G12A (16.6%).
Conclusion. Somatic mutations in RAS and BRAF genes in colorectal cancer were detected in 48.4% of patients in the Tambov region. Among them, there is a predominance of KRAS mutations 81% in females. KRAS oncogenic mutations are predictors of treatment response and prognosis.
Irritable bowel syndrome: current aspects of etiology, pathogenesis, clinic and treatment: A review
Authors: Trukhan Dmitry I. , Goloshubina Viktoriia V.
Published: November 2022

Among functional gastrointestinal disorders, Irritable bowel syndrome (IBS) rightfully continues to maintain its leading position. IBS is a kind of standard for understanding the pathogenetic essence of functional diseases of the digestive system, since it is the most common, studied and studied pathology. So, for the query "Irritable Bowel Syndrome" in the electronic database PubMed as of July 30, 2022, 16 599 sources were found, and for the query "Irritable Bowel Syndrome" in the scientific electronic library eLIBRARY.RU 6316. The first part of the review deals with topical aspects of the etiology, pathogenesis and clinical presentation of IBS. The urgency of the problem of IBS is associated with a significant decrease in the quality of life of patients. The review focuses on the role of psycho-emotional disorders, changes localized at the level of the intestinal wall; and a new coronavirus infection COVID-19 in the development of IBS. Abdominal pain as the leading manifestation of IBS is associated primarily with spasm. In this context, antispasmodic drugs can be considered not only as symptomatic agents, but also as pathogenetic therapy for IBS. In the second part of the review, the possibilities of one of the myotropic antispasmodics, mebeverine hydrochloride, in the treatment of IBS are considered in detail.
Painted Turtles Solve a Detour Task Using Proximal Cues
Authors: Kochen William , Gomerez Jeanny , Powers Alice
Published: November 2022

Painted turtles (Chrysemys picta) are a common species of pond turtle, which forage for food in shallow water and on land, necessitating navigation around obstacles. A detour problem in the laboratory is one in which an animal is presented with a goal on the opposite side of a barrier, so that the only way the individual can reach the goal is to navigate around the barrier. As such, the detour problem presents a challenge for animals similar to what they find in the wild. They must use their spatial understanding of the environment to navigate around the detour and obtain the food. In this study, we investigated a detour problem in which painted turtles had to find their way around a barrier to obtain food as the reward. We then tested them on their use of intra-apparatus (proximal) and extra-apparatus (distal or room) cues. All turtles solved the problem on the first trial, and almost all of them did so consistently over days. They did not show improvement in speed over trials, and they went to different sides on different days, suggesting that they were not learning the task but were solving it anew each day. When the apparatus was rotated in the room, their behavior did not change, showing that they were using proximal, not distal, cues to navigate the detour. These findings demonstrate that painted turtles can solve a detour without the need for experience with the contingencies of the task and that they rely on intra-apparatus (proximal) cues to do so. They add to the growing body of findings that demonstrate that non-avian reptiles can master a detour task.
A Low-Cost Solution for Documenting, Tracking, and Verifying Cage-Level Animal Husbandry Tasks Using Wireless QR Scanners and Cloud-Based Spreadsheets
Authors: Hobson Elizabeth
Published: November 2022

Animal care is a critical component underlying successful behavioral and cognition research. Technological solutions for documentation and verification of care can aid in monitoring that activities are completed according to standard operating procedures and ensure that no individuals are overlooked. Here, I summarize a low-cost, flexible, and easy to use system that I developed to document and monitor care of animals for our research group. The system enables real-time and remote-enabled verification that critical daily tasks have been completed for every cage and helps us monitor our longer-term tasks to make sure that our care team is adhering to our set schedule. The main materials and components needed to implement this system are QR codes, a thermal laminator, a QR scanner, a computer to manage data input, and a database into which the data are scanned and summarized. There are six steps to setting up our system: (1) purchase a QR scanner, (2) generate and print QR codes, (3) set up the central hub for data input, (4) input data from QR scans, (5) filter and collate the raw data, and (6) summarize filtered data to verify and track care. Paired with simple scripts in a cloud-based spreadsheet, scanned QR code data can then be easily summarized in real time to provide verification of care. The flexibility of the system allows it to be customized to a large range of species.
Upaya Mempercepat Proses Involusi Uterus dan Memperlancar Asi Dengan Pijat Oksitosin
Authors: Yuliawati Yuliawati , Anggraini Yetti , Sadiman Sadiman
Published: November 2022

Data Kemenkes pada 2015 tercatat ada 305 ibu meninggal per 100 ribu orang. Menurut WHO (2008) seperempat dari seluruh kematian ibu di tahun 2016, 32 persen diakibatkan perdarahan antepartum dan post partum, sementara 26 persen diakibatkan hipertensi yang menyebabkan terjadinya kejang, keracunan kehamilan, sehingga menyebabkan ibu meninggal (Kemenkes RI, 2013). Salah satu penyebab perdarahan adalah terjadinya sub involusi uterus. Sub involusi uterus adalah keadaan menetap atau terjadinya retardasi involusi. Proses normalnya menyebabkan uterus kembali ke bentuk semula. Akan tetapi, fenomena di lapangan, masih banyak ditemukan ibu nifas hari ketiga dengan TFU masih satu jari dibawah pusat, padahal seharusnya sudah tiga jari dibawah pusat. Hal ini mengindikasikan masih banyak ibu nifas yang mengalami keterlambatan penurunan TFU. Pemberian ASI eksklusif juga masih rendah, berdasarkan hasil Riset Kesehatan Daerah (RISKESDAS) (2013) pemberianASI ekslusif pada bayi selama enam bulan hanya 40,6% jauh dari target nasional yang mencapai 80%. Upaya untuk mengatasi hal tersebut salah satunya dengan pijat oksitosin. Pijat oksitosin adalah pemijatan pada sepanjang tulang belakang (vertebrae) sampai tulang costae kelima-keenam dan merupakan usaha untuk  merangsang  hormon  prolaktin  dan  oksitosin  setelah  melahirkan. Manfaat pijat  oksitosin  adalah memberikan  kenyamanan  pada ibu, mengurangi bengkak (engorgement), mengurangi sumbatan ASI, proses involusi, merangsang pelepasan hormon oksitosin, mempertahankan produksi ASI ketika ibu dan bayi sakit. Pengabmas ini bertujuan untuk memberikan informasi dan penyuluhan tentang pijat oksitosin untuk mempercepat proses inivolusi dan memperlancar ASI. Kegiatan pengabmas ini melatih kader dan  ibu menyusui untuk dapat melakukan pijat oksitosin secara mandiri. Metode pemecahan masalah yang dilakukan berupa penyuluhan tentang pijat oksitosin, dengan langsung  mendemonstrasi dan kemudian mempraktikkan langsung pada ibu-ibu menyusui langkah-langkah pijat oksitosin sesuai dengan procedural. Hasil kegiatan pengabdian masyarakat menunjukkan bahwa ada pengaruh pijat oksitosin terhadap perubahan tinggi fundus uteri dan kelancaran pengeluaran  ASI pada ibu post partum normal, ada pengaruh pijat oksitosin terhadap perubahan tinggi fundus uteri dan kelancaran pengeluaran ASI pada ibu post SC.  Pengabmas ini diharapkan bidan dapat mensosialisasikan teknik-teknik komplementer dimulai dari ibu hamil, ibu bersalin, dan ibu nifas, khususnya pijat oksitosin pada ibu  nifas  yang bertujuan untuk mempercepat proses involusi uterus dan memperlancar pengeluaran ASI.
La responsabilidad en las declaraciones públicas
Authors:   Florida State University, Tallahassee, Florida, US, Bailey Jon S. , Burch Mary R. ,   Tallahassee, Florida, US
Published: November 2022

Esta norma presenta los requisitos para los analistas de conducta cuando hacen declaraciones públicas sobre sus clientes. Esto puede ser en presentaciones de conferencias o en seminarios web, o en un sitio web privado o corporativo o en una publicación. La información personal de un cliente también incluye la documentación relacionada con la evaluación o el tratamiento de la conducta. Según este punto del código, las partes relacionadas con el cliente también tienen derecho a la privacidad, al igual que los aprendices y supervisados con los que trabaja el analista de conducta. Este derecho a la privacidad se extiende también a la información confidencial que el BCBA haya podido conocer en conversaciones con clientes o partes interesadas o que haya escuchado por casualidad mientras estaban cerca. Esto es similar al concepto de secreto profesional entre abogado y cliente, que se amplía para incluir a los analistas de conducta...
Responsabilidad en la investigación
Authors:   Florida State University, Tallahassee, Florida, US, Bailey Jon S. , Burch Mary R. ,   Tallahassee, Florida, US
Published: November 2022

"La mayoría de las normas del código ético se refieren a la prestación de servicios directos a los clientes. Sin embargo, hay algunos temas adicionales contemplados en el código, y la Responsabilidad en la Investigación es uno de ellos. Aunque trabajen principalmente como consultores o asistentes de conducta, habrá ocasiones en las que los analistas de conducta en activo se encuentren en programas o cursos de postgrado en los que participen en el diseño y la realización de un proyecto de investigación (Bailey y Burch, 2018/2021). Las consideraciones éticas son de suma importancia a la hora de llevar a cabo una investigación y, en la mayoría de los casos, las cuestiones éticas serán supervisadas por las comité de ética institucional (CEI) que existen para aprobar, supervisar y revisar la investigación. La función principal de las CEI es proteger el bienestar de los participantes en la investigación en humanos, y este código ético proporciona un nivel adicional de especificidad en el campo de la ética profesional...