bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of the ultrastructure of the skin of white rats 30 days after modeling of portal hypertension
Authors: Hrytsevych Nazar , Vereschaka Volodymyr
Published: January 2023

The problem of skin repair under the conditions of systemic increased pressure in microvessels has a great importance. This is due to the fact that each year the incidence of this pathology has seen an increase during different operations, including plastic surgery. As the compensatory and reparative mechanisms occurring in the skin affected by vascular hyperbaria are still unidentified, the aim of the study was to investigate the features of the ultrastructure of the skin of white rats 30 days after modeling of portal hypertension. Objects of the study were anterior abdominal wall biopsies for electron microscopy research.

Our work demonstrated that the skin in intact animals (control group) was of typical structure before the beginning of the experiment and 30 days after a sham operation. Following 30 days modeling of portal hypertension, the ultrastructure of the epidermis was found to be intact, only slight thickening of the horny layer was revealed. However, in the basal epidermocytes, signs of crypts formation by cytolemma were revealed. Moreover, in the epidermocytes of the spinous and granular layers, the mitochondria, endoplasmic reticulum channels and ribosomes were almost non-evident. In addition, in the cytoplasm of the fibroblasts, a moderate amount of freely located ribosomes and a moderate number of polymorphic mitochondria were detected, while the lumens of the capillaries of the papillary layer of the dermis were narrowed. We also saw that the swelling of the cytoplasm in endothelial cells resulted in the narrowing of the microvessels lumen. What is more, the subendothelial zone was expanded – which is indicative of endothelial desquamation. Beyond the aforementioned, the nuclei of the endothelial cells were well contoured and had signs of chromatin condensation. Endothelial cells with signs of apoptosis were detected as well.
The study of fatty acid composition in Cockscomb (Сelosia cristata (L.) Kuntze)
Authors: Deyneka Alina , Protska Viktoriia , Zhuravel Iryna , Kyslychenko Oleksandra
Published: January 2023

Cockscomb (Сelosia cristata (L.) Kuntze) is a well-known decorative plant belonging to the Amaranthaceae L. family. It is used in South East Asia folk medicine as an anesthetic, anti-microbial, hemostatic, tonic and anti-inflammatory drug. Some 11 to 12 fatty acids have been identified in cockscomb roots, leaves, stem, herb, flowers and seeds, and their quantitative content has been determined by gas chromatography. Accordingly, in all herb samples, unsaturated fatty acids dominated, forming 68.18 to 75.93% of total content. Mostly, these compounds were accumulated in the roots. Among the unsaturated fatty acids, linoleic acid prevailed in roots, stems, herb, flowers and seeds, whereas linolenic acid prevailed in the leaves. The highest content of linoleic acid (45.57±1.14%) was found in the seeds, while that of linolenic acid (53.63±0.53%) was found in the leaves. The obtained results will be applied in the development of drugs on the basis of cockscomb herb lipophilic fraction.
Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil
Authors: Al-Hamdany Muna , Al-Tai Faten , Ismail Hanaa K.
Published: January 2023

Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil is a common flavoring used in foods and drinks. To investigate the defensive action of Peppermint oil against the hepatic and renal histological damage induced by Piroxicam in mice.

Forty healthy adult Swiss albino mice of both sexes were categorized into 4 groups (10 mice in each group): Control group (I); Treatment group (II) – injected with Piroxicam 0.3 mg/kg/rat/day via intraperitoneal route for 28 days; Treatment group (III) – oral Peppermint oil 0.2 ml/kg/day by oral gavage 24 hours preceding each injection of Piroxicam; Treatment group (IV) oral Peppermint oil alone. Blood samples were withdrawn to estimate the hepatic and renal functions. Immediately after death, specimens of liver and kidney from the four groups were isolated and put in 10% concentration buffered formalin for 24 hours then prepared for light microscopic examination.

There was a highly significant rise in the serum level of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase and total serum bilirubin) in the group treated with Piroxicam, as compared to the control group. These returned to near normal level in the group treated with Piroxicam and Peppermint oil. Liver samples of the treated mice showed ballooning degeneration of hepatocytes, small apoptotic hepatocytes and inflammatory cellular infiltration, whereas kidney sections revealed cystic dilatation of Bowman’s space, shrinkage of glomerular tuft and apoptosis of epithelial cells lining the tubules. In contrast, the addition of peppermint oil efficiently ameliorated the hepatic and renal tissue changes.

Piroxicam induces hepatorenal toxicity as exhibited by histological, histochemical and biochemical findings. Peppermint oil shows ameliorative properties against the hepatorenal toxic effects induced by Piroxicam.
The protective effect of vitamin A on Concor induced structural changes of the liver and kidney in adult rats
Authors: Ahmed Mareb H. , Taeel Faten Dhanoon
Published: January 2023

Concor is a beta-blocker drug used to treat high blood pressure, acute coronary syndrome, and to control the rapid pulse of the heart such as atrial fibrillation. Some of its adverse effects include hepatitis, increased triglycerides and liver enzymes. Monitoring liver and kidney functions in patients with hepatic or renal impairment who are taking concor is recommended.

The current study was undertaken to define whether vitamin A could improve structural changes in the liver and kidneys. The 24 rats were grouped into the following. The first group was control. The second group was given Vitamin A (5000 IU). Group 3: given concor at a daily dose of 0.9 mg/kg B. wt. Group IV: received concor (0.9 mg/kg B. wt.) and Vitamin A (5000 IU) orally. After 4 weeks, the kidney of the treated group 3 exhibited degenerative alterations in the glomeruli, enlargement of Bowman’s space and the epithelium of the proximal kidney tubules showed vacuolar degeneration with necrosis. Liver sections showed degeneration and necrosis of hepatocytes, congestion of the central vein, dilation of sinusoids and inflammatory cell infiltration. Group 4 showed mild degeneration in the glomeruli, expansion of Bowman’s space and mild degeneration of tubular epithelium, and normal architecture of the liver with increased Kupffer cells. From this study, we concluded that concor drug induces structural changes in the liver and kidney and these effects were improved by Vitamin A administration.
Phytochemical analysis and evaluation of antibacterial activity of Moringa oleifera extracts against gram-negative bacteria: an in vitro and molecular docking studies
Authors: Ganjo Aryan R. , Adham Aveen N. , Al-Bustany Hazem A. , Aka Safaa T.
Published: January 2023

Moringa oleifera seed and leaf are used traditionally for the treatment of various health problems (among others, hypertension, scrapes, skin infection, diabetes, genitourinary illnesses), and to boost the immune system, as well as to act as a contraceptive. In this study, the antibacterial activity of seed and leaf M. oleifera extracts on three-gram negative bacteria was investigated, and phytochemical analysis for the association of antibacterial activity with the active constituents in the plant was determined. Moreover, understanding of the mechanism of action was achieved by applying the Auto Dock Vina technique. The phytochemical screening of M. oleifera seed and leaf extracts exhibited the presence of alkaloids, carbohydrates, cardioactive glycosides, flavonoids, tannins, phenols, steroids and terpenoids. In silico results revealed that compounds (4-O-caffeoyl quinic acid, 4-(α-L-rhamnopyranosyloxyl)-benzylisothiocyanate); (Isoquercitrin, 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate); and (Astragalin, 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate) from leaf and seed have the highest binding affinity and very good interactions with Transcriptional Activator Protein (LasR), Klebsiella pneumoniae carbapenemase (KPC), and Malonyl-CoA-acyl carrier protein transacylase (FabD), respectively.
Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant
Authors: Traczuk Adam , Polak Beata
Published: January 2023

Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were investigated through the use of the thin-layer technique with its mobile phase containing surfactant. Assessment of the effect of surfactant presence and 1-propanol concentration in the mobile phase on the retention and separation of investigated solutes was then carried out wherein the effect of the surfactant concentration on the zone shape properties (asymmetry and tailing coefficient) was investigated. The method was applied for the quantitative analysis of the chosen solutes, and the LOD and LOQ values of chosen were determined. These were as follows: acebutolol – 1.11 and 3.36 μg/spot, metoprolol 1.45 μg/spot, 4.4 μg/spot. The chosen system is environmentally friendly due to using silica gel plates and only 5% of propanol in water.
Sepsis by Streptococcus pneumonia serovar 4 in diabetic patient with splenectomy
Authors: Alqahtani Ali , Alyabis Saud , Alqahtani Saud , Alotaibi Salal , Aljuzayri Zahra
Published: January 2023

Background: Streptococcus pneumonia had many serious serovars for which the vaccination was not yet developed, immunocompromised patients and patients with splenectomy were more susceptible to infection and sepsis by these organisms.
Case Presentation: We describe a septic shock syndrome patient, who is diabetic with splenectomy, whose sepsis is caused by S. pneumonia. The patient had a pneumococcal vaccination after having a splenectomy due to abdominal trauma 5 years ago. Strain 4 of S. pneumonia caused the patient's septic shock.
Results: Patient's condition improved after 4 weeks of treatment with antibiotics, thrombolytic, renal replacement therapy, and discharged in a good condition, no surgical procedures were needed apart from skin debridement of necrotized tissues.
Conclusion: This instance demonstrates the necessity of considering illnesses caused by bacteria that patients have been immunized against when making a differential diagnosis because there are so many serovars present. Even though vaccine development has increased the development of vaccination for S. pneumonia serovars from 7 to 23 in recent years, there is still a need for novel vaccines that can offer more generalized immunity against other serovars.
Tea and Tea Product Diversification: A Review
Authors: Zohora Kanij Fatema Tuz , Arefin Md. Riyadh
Published: January 2023

Tea is the most consumed drink after water as well as is one of the prevalent and the cheapest beverage which consumed globally. Tea is considered a healthy beverage due to the presence of several antioxidants and minerals such as potassium, magnesium, calcium & manganese. Different kinds of teas are manufactured in different countries based on taste, habit and culture of the people. Normally, tea can be categorized into three groups: green tea (unfermented), Oolong tea (partially fermented) and black tea (fully fermented) based on tea processing. Tea is a rich source of polyphenols and now-a-days interest in the possible health benefits of polyphenols, particularly flavonoids, has increased owing to their antioxidant and free-radical scavenging abilities. The rising demand of tea is considered one of the significant components for the worldwide beverage market growth. Tea industry makes a vital contribution to the economy of the respective tea producing countries like China, Japan, India, Sri Lanka, Bangladesh, Kenya etc. At the present time with the rising demand of tea it is needed to emphasize for exploring alternative means of increasing profits from tea cultivation. The tea market price is low in Different countries like Srilanka, India, Bangladesh, Kenya etc. comprises with high cost of production. For this reason, there is no alternatives rather than product diversification of tea through value addition which can be an important approach to mitigate the impacts of low market price and high production costs. This review broadly focuses on the issues leading to the development of wide range of tea and tea product diversification. This paper is also associated health benefits with different types of tea, nutraceutical beverage, confectionary items, toiletries and cosmeceuticals which being commercialized in different parts of the world which are gaining consumer acceptance and also face the challenges of global marketing by tea industries that’s are described in this paper.
An Evaluation of Nutritional Security Impacts of Climate-Smart Adaptation Practices among Smallholder Farmers of Eastern Oromia, Ethiopia
Authors: Yuya Beyan Ahmed , Haji Mohammed Jema , Ketema Aredo Mengistu
Published: January 2023

Climate impact mitigation through improved agricultural practices is one means by which agricultural productivity increases to meet the growing food demands in the world. This study evaluated the impacts of climate-smart Practices on rural households’ nutrition security. The study used both primary and secondary data sources. Primary data was collected from sample respondents in the 2020/21 production year. Descriptive statistics and econometric models were employed for data analysis. Multinomial logit result indicated that the probability of adopting climate-smart agricultural practices is influenced by the education level of the head, extension contact, livestock holding, membership coop, market information, advice on land management, climate change information, farmers training, climate change perception, and weather road distance. The result from GPS estimation indicated that treatment level two the number of climate-smart practices increases household nutritional status by16%. Likewise, treatment level three and four of the number of climate-smart practices increases the household level nutritional status by 37% and 76% respectively over that of treatment level one of the climate-smart practices and is significant at a 1% statistical probability level. This study has found evidence that the adoption of climate-smart on the households’ nutrition security status. Therefore, the result of this study would be expected to significantly contribute as policy and strategic inputs for policymakers in designing rural livelihood improvement policies and to the beneficiary in enhancing their welfare and living standard.
Camel Milk Production System in Türkiye
Authors: Koç Atakan
Published: January 2023

Camels are known as "ship of the desert" and "beast of burden" and resistant to harsh climatic conditions. Their function has changed in the modern world and they have become a food source like other farm animal species. In the last 60 years, the number of camels, their meat and milk production in the world have increased 3.0, 4.95 and 5.0 times, respectively. In Türkiye, both Bactrian and dromedary camels are reared since F1 hybrid ♂ Tülü (Bactrian ♂ x dromedary ♀) perform better in camel wrestling, which is a unique culture of Anatolia. There are also a few farms aiming to produce camel milk and rearing young camels intensively in Türkiye. However, many practices such as calf rearing, insemination of cows, milking stimulation, milk preservation, milk quality control, milk collection and marketing and milk processing into the products are not as modern as in dairy cattle production. Although dairy camel farms in Türkiye have a higher milk production potential, since high milk prices lead to low demand for camel milk and there is only one camel milk processing facility to turn camel milk into products, farms produce far below their capacity. Processing camel milk into the products such as cheese, whey, yoghurt, pasteurized milk, kefir and ayran is still in its infancy. In conclusion, although the basis of camel rearing in Türkiye today is based on wrestling camel breeding, understanding of the benefits of camel milk on human health and the increase in demand for camel milk products suggest that this situation will change in favour of dairy camel breeding in the near future.
Determination of Sustainability Indicators of Nut Farms: The Case of Pistachio
Authors: Doğan Öz Belma , Saner Gamze
Published: January 2023

The aim of this study is to determine the indicators used to determine the sustainability levels of nut farms and to establish a set of indicators that can be used to measure the level of sustainability of pistachio farms, based on the literature review. As a result of the literature review, among the indicators commonly used to measure agricultural sustainability, a total of thirty sub-criteria were identified, including fifteen sub-criteria for the economic aspect (farm size, yield, etc.), six sub-criteria for the environmental aspect (pesticide, fertilizer, water, energy usage, etc.) and nine sub-criteria for the social aspect (farmer’s age, education, etc.) which can be used in evaluating the sustainability of pistachio cultivation. According to this study's findings, although the theoretical principles, dimensions, and goals of agricultural sustainability are globally adaptable, the applicability of the indicators may vary between regions and countries due to geographic, climatic, and socio-cultural differences. Therefore, the sustainability assessment process requires special attention. Sufficient knowledge and expertise are required in setting goals, selecting indicators, and verifying indicators.
Results of Computational and Experimental Studies on the Long-Term Safety Justification of Deep Disposal Facilities for LRW
Authors:   State Corporation Rosatom, Dorofeev A. N. , Ponizov A. V. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Rybalchenko A. I. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Zakcharova E. V. ,   Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Zubkov A. A. ,   Joint stock company “Siberian Chemical Combine”, Vereshchagin P. M. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Vasilishin A. L. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Murlis D. V. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Sharafutdinov R. B. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Saveleva E. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Suskin V. V. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: January 2023

The article overviews the findings of individual studies under the Program of Calculation and Experimental Research Seeking to Demonstrate and Assess the Long-term Safety of Deep Disposal Facilities for Liquid Radioactive Waste Aiming to Implement the Recommendations of the IAEA Peer Review of the Deep Well Injection Practice for Liquid Radioactive Waste in the Russian Federation. To demonstrate the long-term safety of the Zheleznogorsk, Seversk and Dimitrovgrad deep disposal facilities for liquid radioactive waste (hereinafter referred to as the DDF LRW), data on the geological and hydrogeological conditions in the regions and at the DDF LRW sites were collected and systematized; the processes occurring in DDF LRW near and far zones, including those involved in radioactive waste (RW) component transport, were studied; evolution scenarios for the RW disposal system were developed, including a forecast describing potential climate changes in the DDF LRW areas covering a period of up to 100,000 years; conceptual and mathematical DDF LRW models were developed; computer software was used in predictive calculations focused on the migration of liquid RW components in the operational DDF LRW horizons with the potential radiation impact on the population been assessed. The study also involved some computational and experimental research focused on the evolution of backfill materials to develop the designs of some additional engineered safety barriers to be installed during DDF LRW DGR well abandonment; the paper also presents the approaches to the development of the DDF LRW closure concept.
TÜRKİYE’DE KADINLARIN PARLAMENTODA TEMSİLİNDE SİYASAL PARTİLERİN ROLÜ
Authors: YÜKSEL Mezher
Published: January 2023

Türkiye’de kadınların parlamentoda temsilinde siyasal partilerin rolünü tartışan bu çalışmanın temel iddiası kadınların siyasal temsilinde ve parlamentonun cinsiyet kompozisyonunun oluşmasında son kertede belirleyici olanın partilerin tutumları olduğudur. Partilerin özellikle aday belirleme ve aday listeleri oluşturmadaki tercihleri kadınların siyasal temsilini doğrudan belirlemektedir. Buradaki tartışmada 1983-2018 arası dönemde yapılan on bir genel seçim sonunda TBMM’ye giren on üç farklı siyasi partinin aday listeleri esas alınmıştır. İlk olarak kadınların parlamentoda temsilinin tarihsel seyri ile mevcut durum ortaya konulacaktır. Daha sonra 1980’lerden itibaren yaşanan ve kadınların siyasal temsilini etkileyen gelişmeler ile partilerin kadın temsili konusundaki yaklaşımları ele alınacaktır. Son olarak, partiler bazında ve dönemler itibariyle yapılacak inceleme ile aday listelerindeki temel örüntüler ve genel eğilimler ortaya konulacaktır. Araştırmanın öne çıkan bulgularından ilki partilerin aday belirleme ve liste oluşturmadaki yaklaşımlarının kadınların parlamentoda temsil düzeyini de belirlediğidir. Partiler arasında listeler bazında yapılan bir karşılaştırmada merkez sağ partiler ile merkez sol partiler arasında büyük farkların olmadığı, milliyetçi sağ ve muhafazakar partilerin cinsiyet eşitliği ve kadınların siyasal temsili düşüncesine en mesafeli partiler olduğu, liderin cinsiyetinin partinin cinsiyet eşitliğine yaklaşımında ve kadın politikasının oluşturulmasında belirleyici olduğu görülmüştür.
Hz. Peygamber’e (s.a.v.) İsnad Edilen Olumsuz Söz ve Fillerle İlgili Bir Hadisin Tahrîc ve Yorumu
Authors: YARBA Rıdvan
Published: January 2023

Hz. Peygamber (s.a.v.), yaklaşık yirmi üç yıl süren peygamberliği süresince Allah’tan peyderpey aldığı vahyi insanlara açıklamak amacıyla birçok söz söylemiş ve birtakım davranışlar sergilemiştir. Allah’ın kendisine koşulsuz itaati emrettiği ve üsve-i hasene olarak takdim ettiği Hz. Peygamber (s.a.v.), peygamberliği boyunca yüce ahlâkıyla mütenasip sözler sarf etmesi ve davranışlar sergilemiştir. Ancak bazı hadislerde ilk etapta Hz. Peygamber’in (s.a.v.) üsve-i hasene, yüce ahlâklı ve beşer oluşuyla örtüşmediği düşünülen birtakım sözler söylediği ve davranışlar sergilediği görülmektedir. Bu duruma işaret eden hadislerden biri, müteaddit tarîklerle birçok kaynakta yer alan ve genel hatlarıyla Hz. Peygamber’in (s.a.v.) bazı Müslümanlara beddua ve lanet türünden sözler söylediğini ve vurduğunu haber veren hadistir. Doğru okunup anlaşılmaması halinde hadisin uydurma olarak nitelenebileceği ve daha önemlisi yanlış bir peygamber tasavvuruna yol açabileceği ortadadır. Bu çalışma, sözü edilen bu hadisi doğru anlayıp yorumlamayı amaçlamaktadır. Bu amaç doğrultusunda öncelikle onun başta Kutub al-Tisʿah olmak üzere hicri ilk üç asırda kaleme alınan eserlerdeki tarîkleri tespit edilmiştir. Daha sonra başta şerhler olmak üzere değişik alanlara dair kaynaklara müracaat edilerek tarihi süreç içerisinde hadisle ilgili yapılan yorumlara ulaşmaya çalışılmış ve birtakım değerlendirmeler yapılmıştır. Neticede tarîklerinin önemli bir kısmı itibariyle hadisin sahîh olduğu anlaşılmış ve tarihi süreçte ona ilişkin yorumların isabetli olduğu kanaatine varılmıştır.
Lumbung Padi Kerinci Sebagai Objek Penciptaan Karya Seni Grafis Gaya Surealis
Authors: Aprisela H Jeki , Rajudin Rajudin
Published: January 2023

The Kerinci Rice Barn is the object of this printmaking. The Kerinci rice barn was chosen as the object of creation because its existence is already threatened with extinction. In fact, the philosophical value of the Kerinci rice barn is very noble and profound. This printmaking is made in a surreal style. The concept of distortion is used to make the work more surreal. The idea behind this work is to use the Kerinci rice barn as an idiom to express oneself through art. The stages of the method in this creation are: contemplation, prototype, and forming. This printmaking work combines the hardboard cut technique with the stencil technique. The media used are acrylic paints and oil-based printing inks on canvas. The creation of this work has resulted in a work entitled "Menabung". This work measures 100 cm x 100 cm.
Dandelion Sebagai Objek Penciptaan Karya Seni Lukis
Authors: Herizqy Herizqy , Erizal Erizal , Nazaruddin Armen
Published: January 2023

Dandelion is a flower that comes from Europe and Asia. This flower can regularly release its seeds and is often considered a fruit. The flower head bears many florets, each producing a single seed. Each seed has a parachute that allows it to fly through the air. Five years ago, when still in school, became interested in dandelion flowers. It was the day of the rice harvest, and see the shape of a white ball being swayed by the wind on the edge of the rice fields. Some of the seeds are released and fly in the wind. This event looks so attractive. The approach used is the representational form approach. The techniques used are aquarel, placard, and impasto techniques. The method used is observation, design, and embodiment. First, direct observations were made in the Dandelion flower environment. Then do the design by sketching directly on the canvas. The next stage is the embodiment stage. Cultivation and exploration of techniques on the canvas are carried out until the work is finished. Finally, the presentation is done in the form of an exhibition. The creation of this work succeeded in producing five works entitled “Gelap Ramai,” “Cemas Untung Tenang,” “Cerah dalam Gelap,” “Bolak-Balik,” “Tenang diaduk Senang.”
Şehzadebaşı’nda Mimar Kasım Ağa Dârülhadisi
Authors: ATEŞ Aysu
Published: January 2023

XVII. yüzyılın Osmanlı başmimarı Kasım Ağa, yapı faaliyetlerinin yanında, özellikle siyasete olan ilgisi ve dönemin sadrazam, padişah hocası, valide sultan gibi önemli kişilikleriyle yakın ilişkisi dolayısıyla öne çıkmaktadır. Devrin sadrazamları tarafından vezirlik taslayan kişiler arasında anılan ve siyasi etkinliği nedeniyle defalarca sürgün edilen, hapsedilen ve katledilmek dahi istenen Mimar Kasım Ağa, başına gelen onca felakete rağmen siyasetle ilgilenmekten vazgeçmemiştir. 1651 yılında başmimarlığı sona eren ve Hadice Turhan Sultan’ın kethüdası olan Kasım Ağa, yakın dostu Köprülü Mehmed Paşa’nın 1656 yılında sadarete getirilmesini sağlayarak, büyük emeline ulaşmıştır. Bu tarihten sonra adına pek rastlanmayan Kasım Ağa’nın, kadı sicillerine dayanılarak 1662 yılında hayatta olmadığı anlaşılmaktadır. Mimarlığından ziyade siyasi yaşamdaki rolü nedeniyle anılan Mimar Kasım Ağa’nın kendi adına başkent İstanbul’da Şehzadebaşı semtinde inşa ettirdiği dârülhadisi, daha az bilinen bâni kimliğini yansıtması bakımından büyük önem taşımaktadır. XVII. yüzyılın ilk yarısında inşa edilen, XX. yüzyıl başlarına dek ayakta olduğu tespit edilen Mimar Kasım Ağa Dârülhadisi’nin konumu, kuruluşu, derecesi, işletim koşulları, geçirdiği onarımlar ve mimarisi ayrı başlıklar altında, Osmanlı arşiv belgeleri ve ağırlıkla El-Hac Kasım Ağa ibn-i Ali adlı vakfiyesine dayanılarak irdelenmiştir. Yapı türü seçiminin ve dârülhadisin konumunun Kasım Ağa’nın siyasi yönüyle ilişkisi üzerinde durulmuş ve günümüze ulaşamayan Mimar Kasım Ağa Dârülhadisi’nin çağın başkentteki Osmanlı medreseleri arasındaki yeri belirlenmeye çalışılmıştır.
Jackson, Gabrielle, Pain and Prejudice: How the Medical System Ignores Women and What We Can Do About It
Authors: Scali Jenna
Published: January 2023

Book Review of Jackson, Gabrielle, Pain and Prejudice: How the Medical System Ignores Women and What We Can Do About It.
Greenhouse lettuce production fertilized with sargassum extract or vermicompost leachate
Authors:   Instituto Politécnico Nacional, Centro de Investigación en Biotecnología Aplicada, Mexico, Juárez-Rangel Ana Patricia , Solís-Oba Aida , Martínez-Cásares Rubria Marlen , Castro-Rivera Rigoberto , Solís-Oba Maria Myrna ,   Universidad Autónoma Metropolitana, Unidad Xochimilco, Mexico
Published: January 2023

The presence of sargassum on the Caribbean coast causes ecological problems, as does the sludge from water treatment plants. Fertilizers like Nutrkam (sargassum extract) and Biofertex (leachate from the vermicomposting of sludge from a textile plant) have been prepared from these two materials. Both biostimulants were applied to a lettuce crop in a greenhouse, the doses were 2, 5, 7.5, 10 and 20% by volume, the results were compared with urea fertilization. At eight weeks, height, number of green leaves and senescent leaves, fresh and dry weight, antioxidant capacity, and flavonoid content were evaluated. With NutrKam at 5, 10 and 20% and Biofertex at 7.5, 10 and 20%, the height of the leaves was statistically equal to that obtained with urea; there was no significant difference in the weight of leaves when fertilizing with 20% NutrKam, 7.5% Biofertex and urea. With all the treatments, except with Biofertex at 10 %, the antioxidant content was higher than that of lettuces fertilized with urea. The use of both materials to prepare fertilizers is an attractive alternative, since on the one hand the pollution caused by their inadequate disposal is reduced, and on the other, their agricultural application would help reduce the use of chemical fertilizers, without impairing the yield and crop properties.
Evaluation of the Antibacterial Activity of the Jackfruit Parasite Leaf Plant Extract (Macrosolencochinchinensis (Lour.) van Tiegh) with Vitro and In Silico approach
Authors: Hilma Rahmiwati , Harahap Suma Rahmani , Syahri Jufrizal
Published: January 2023

In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, the purpose of this investigation is to learn more about the bioactive components and antibacterial activity of n-heksan, etilasetat, and etanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing, both of which were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. This suggests that punicalin and rutin have the ability to inhibit the growth of bacteria.
Dimensional Reduction of QSAR Features Using a Machine Learning Approach on the SARS-Cov-2 Inhibitor Database
Authors: Azizah Munaya , Yanuar Arry , Firdayani Firdayani
Published: January 2023

Quantitative Structure-Activity Relationship (QSAR) is a method that relates the chemical composition of a molecule to its biochemical, pharmaceutical and biological activities. The characteristics of a molecule's chemical constituents, such as chemical descriptors and fingerprints, are necessary to create a good QSAR model. Dimensionality reduction can alleviate the issue of several unnecessary and redundant chemical descriptors and chemical fingerprints in a high-dimensional feature-number data set by shrinking the high-dimensional original space to a low-dimensional intrinsic space. There are two categories of dimensional reduction techniques: feature extraction and feature selection. The dimension reduction approach can be utilized as a starting step in running a QSAR Virtual Screening Model on a dataset of SARS-CoV-2 inhibitor medications to create novel treatments for Covid-19 cases based on machine learning (ML) and the idea of medicinal repurposing. Fe extraction and feature selection are crucial to determining which feature sets should be applied to a specific classification process in QSAR modeling to produce reliable virtual screening results. The SARS-Cov-2 inhibitor drug database's chemical descriptor and chemical fingerprint were extracted using a simple, quick, and accurate method in this work. The total number of selected features is 12122 features. PCA, Missing values, and Random Forest are the techniques employed. The Xgboost Tree Ensemble, Naive Bayes, Support Vector Machine, Random Forest, and Deep Learning (Artificial Neural Network/Multilayer Perceptron) were used to classify the QSAR modeling on the training and test data. The Random Forest approach, when applied to all chemical descriptors and chemical fingerprint features, along with the XGBoost algorithm, yields the best feature selection results (accuracy value of 0.845 and AUC of 0.904). There are 233 characteristics for the regression QSAR approach and 273 features for the feature selection-based QSAR method of classification. Next, virtual screening of QSAR modeling of prospective drugs for Covid-19 therapy can be done utilizing the outcomes of the characteristics that have been chosen using the Random Forest approach
Peran Locus Of Control Internal Terhadap Kemampuan Pemecahan Masalah Akademik Pada Mahasiswa Pengurus Organisasi
Authors: Widyayanti Neni , Hazanariah Hazanariah , Khairunnisa Nadea Zulfa
Published: January 2023

This study aims to examine the relationship between internal locus of control and academic problem solving skill in student organization. The hypothesis in this study is that there is a positive relationship between internal locus of control and the ability to solve academic problems in organizational students. Research respondents (N = 200) are active students, are administrators or active members in community service and are aged 17-22 years. Collecting data using academic problem solving skill scale and internal locus of control scale. The analysis in this study was tested with a correlation technique, namely Spearman carried out using the help of SPSS for Windows version 22.00. The results of the analysis show that there is a significant positive relationship between internal locus of control and academic problem solving abilities in student organizations.
Pengaruh Pemupukan Dan Pemangkasan Terhadap Pertumbuhan Dan Hasil Melon (Cucumis melo L.) di Lahan Kering
Authors: Jayaputra Jayaputra , Santoso Bambang Budi , Jaya Komang Damar
Published: January 2023

The aim of this study was to determine the effect of a combination of NPK fertilizer and liquid organic fertilizer (POC) and pruning and its interaction on the growth and yield of melon plants on dry land. The experiment used a two-factor factorial randomized block design, namely: Application of NPK + Liquid Organic Fertilizer (POC) (b0 = 100% NPK without POC; b1 = 50% NPK + Bio-Extrem POC; b2 = 50% NPK + Organox POC) ; and Pruning (p0 = No Pruning, p1 = Pruning by maintaining 2 main branches). The results showed that pruning had a significant effect on the percentage of class C fruit quality, while fertilization treatment had no significant effect on all observed parameters. The interaction of the combination of fertilization and pruning had no significant effect on the growth and yield of melons, however, the combination of fertilizing with pruning was able to avoid fruit weight <1 kg (class C fruit quality). The use of a combination of 50% NPK + POC (Bioektrim / Organox) fertilizer and pruning can be used as a technology package in an effort to reduce the use of inorganic fertilizers and increase the yield and quality of melon fruit on dry land.
Improving students’ motivation in calculus courses at institutions of higher education: Evidence from graph-based visualization of two models
Authors: Hammoudi Mohamad Mustafa , Grira Sofiane
Published: January 2023

This research aims at improving students’ motivation for success in calculus courses at higher education institutions by developing two models. The first model is developed to promote students’ intrinsic motivation. The second model is integrated with the first model to improve students’ intrinsic and extrinsic motivation. A mixed research methodology is used, which includes 153 students in calculus courses at three universities in the United Arab Emirates. The qualitative results of 15 interviews are divided into three themes including students’ motivation for success in calculus, their mathematics self-concept, and other supporting elements. The regression analysis shows that 72.5% of the variation in students’ intrinsic motivation for success in calculus is explained by five variables in model I and 98.5% of the variation in their intrinsic and extrinsic motivation is explained by three variables in model II. The findings of this study can be utilized by higher education institutions that offer calculus courses.
Pre-service mathematics teachers' numeracy in Acehnese culture-based minimum competence assessment
Authors: Marhami Marhami , Rohantizani Rohantizani , Muhammad Iryana , Samsidar Samsidar , Anggraini Intan
Published: January 2023

Pre-service mathematics teachers must have good numeracy skills because this ability is needed in all aspects of life, home, work, and society. This study aims to identify the numeracy skills of pre-service teachers on the Acehnese culture-based Minimum Competency Assessment (MCA). A descriptive quantitative method was used in this study with 24 numeracy MCA questions based on Acehnese culture as an instrument. The subject was 158 mathematics education students from three Aceh universities in their fourth and sixth semesters. The data were analyzed quantitatively and categorized based on high, medium, and low levels. The results showed that the overall numeracy ability of pre-service mathematics teachers is 50.06% in the medium category. At the level of knowing and applying, they received 69.38% and 46.62%, which were in the medium category. Meanwhile, they only obtained 39.76% in the low category for reasoning level. It indicated the student’s lack of ability in higher-order thinking. These results are expected to be input for educators to arrange learning that develops the numeracy skills of pre-service teachers.
The impact of undergraduate students’ mathematics anxiety and self-concept on their self-regulated learning and academic achievement
Authors: Cahyawati Dian , Delima Nita , Gunarto Muji
Published: January 2023

Several types of research showed math anxiety as the learning outcome, but another showed that as the predictor variable. Math anxiety was predicted based on other variables, such as self-regulated learning and self-concept. Self-regulated learning is associated with academic achievement. This study aimed to obtain valid and significant indicators of each latent variable and to develop the structural model of those latent variables on students’ academic achievement. The research used an interval scale questionnaire to measure all latent variables except academic achievement. The PLS-SEM was applied by SmartPLS software. The structural model showed that math anxiety directly affected academic achievement but indirectly affected self-regulated learning, which is self-concept as the mediating variable. For students with low math anxiety, their self-regulated learning tends to be high by controlling their self-concept in math.
Developing an electronic module based on mathematical literacy to enhance students' mathematical reasoning
Authors: Marsitin Retno , Sesanti Nyamik Rahayu
Published: January 2023

This study aims to produce an e-module based on mathematical literacy with a valid, effective, and feasible problem-based learning approach to improve students' mathematical reasoning in multivariable calculus material. This research used a development method with the stages: analysis, design, development, and evaluation. The research subjects involved fifth-semester students' mathematics education department. Small group trials with 17 students and large group trials with 35 students. The research instruments included validation sheets, student worksheets, questionnaires, and mathematical reasoning ability test questions. Data collection used the results of the validation as validity, test results as effectiveness, and the results of the questionnaire as feasibility. Data analysis was descriptively and qualitatively. The research produced an e-module based on mathematical literacy with a problem-based learning approach that is valid, very effective, and very feasible for improving students' mathematical reasoning abilities in multivariable calculus material. The developed e-module has the potential for significant differences and increases mathematical reasoning abilities. In addition, e-module can be used as an alternative solution to electronic teaching.
Gender differences in mathematics anxiety and learning motivation of students during the COVID-19
Authors: Ulfah Syafika , Akmalia Rizka , Jusra Hella
Published: January 2023

The COVID-19 pandemic is causing a change in the field of education, where learning is currently becoming online. It affects the psychology of the students. This study aimed to analyze the mathematics anxiety and learning motivation of secondary students based on gender during the pandemic. This study was quantitative research. The participants in this study were 451 eighth-grade students of State Secondary School in South Jakarta. The instrument used was a questionnaire. It consisted of 45 statements belonging to 22 items on mathematics anxiety and 23 items on student learning motivation. The data analysis applied was descriptive, Mann-Whitney test, and correlation analysis. The results found that students' mathematics anxiety during the COVID-19 pandemic was moderate. Meanwhile, students' learning motivation was in the high category. In addition, there were significant differences in mathematics anxiety levels between male and female students. However, there was no significant difference in the motivation of learning mathematics students. The correlation between mathematics anxiety and learning motivation indicated a negative relationship.
A ANÁLISE SARTRIANA SOBRE A CONSTRUÇÃO EGO DO ESCRITOR JEAN GENET FRENTE A SUA LIBERDADE
Authors: Erculino Siloe Cristina do Nascimento , Rangel Silênia de Azevedo Silveira
Published: January 2023

A partir da psicanálise existencial sartriana, descrita na obra Saint Genet: Ator e Mártir, analisaremos os caminhos tortuosos que a subjetividade percorre na tentativa de se plenificar como objeto.  Nosso propósito é demonstrar que Genet buscou identificar-se com seu ego para se colocar como um objeto de desprezo para a sociedade, porém, sua busca fracassa, pois, segundo Sartre, o homem jamais será completamente objetividade alienada no mundo. Nesse intuito, descreveremos brevemente os principais momentos da vida de Genet. Em sua infância, teve seu ego-visto (ser-para-outro) constituído pelo olhar de outrem; a partir de então, realizou diversos esforços para se identificar com essa imagem alienada, entretanto - enquanto liberdade -, permaneceu frente a todas as suas tentativas de fixar um ego maldito com o qual se identificasse; e, por fim, encontrou apenas a sua própria subjetividade, exercendo sua liberdade no ofício de escritor. Concluiremos, portanto, que a subjetividade permanece livre e responsável, mesmo frente à construção do seu ego.
NORBERTO BOBBIO: O EXISTENCIALISMO NA PERSPECTIVA DO DECADENTISMO SARTRIANO
Authors: Santos Tiago Soares dos , Pinheiro Reginaldo Cesar
Published: January 2023

Este trabalho analisa e o decadentismo bobbiano dialogando-o com existencialismo sartriano. As duas grandes guerras mundiais ocorridas na Europa impactaram significativamente os campos da política, da economia e da cultura europeia. A crise foi vivida pela elite como uma decadência. A crise da filosofia ou filosofia da crise resultou no surgimento do decadentismo, que se constitui em um movimento existencialista que propôs a reflexão sobre a experiência humana no mundo. Amparado no existencialismo proposto por Kierkegaard, Heidegger e Jaspers o decadentismo promove uma tomada de consciência e a exaltação de uma posição diante da vida. Bobbio tem em Jean-Paul Sartre a mais perfeita encarnação do intelectual decadente, na medida em que se constata que os personagens sartrianos são predominantemente decadentes e tem como característica principal a contínua interação entre a reflexão e a vida, entre a paixão vivida e a que se coloca em frente ao espelho da consciência. Metodologicamente o estudo foi desenvolvido por meio da análise da obra El Existencialismo: ensayo de intepretación de Norberto Bobbio e Existencialismo é um humanismo e o Ser e o Nada: Ensaio de uma Ontologia Fenomenológica de Sartre. Nesse sentido, a filosofia da crise esboçada pelos dois pensadores permite uma reflexão profunda sobre a experiência humana no mundo, com a possibilidade constante de estabelecer projetos de realidade humana no mundo.
Reconstruction of Supervision in Online Trial as Evaluated Review During the Covid-19 Pandemic
Authors: Sriwidodo Joko
Published: January 2023

The various problems encountered during online trials highlight an impaired supervision mechanism. This research is part of a need for a reconstruction in the supervision of online trials in Indonesia. Therefore, the formulation of the problem is: What are the problems that arise in online trials during the Covid-19 pandemic? How can the reconstruction of supervision in these trials be carried out? Furthermore, a descriptive, normative method was applied alongside a qualitative, statute approach. The results showed that problems related to the supervision of online trials include the absence of clear legal rules and procedures that have not been regulated in Indonesia Law. It is necessary to supervise judges during these trials, and this supervision has not involved the Indonesian judicial system, specifically the Judicial Commission or KY. Therefore, there is a need for reconstruction in supervision through the Revision of the Criminal Procedure Code (KUHAP), the Establishment of Special Regulations Related to the Online Trial Law, and the Formation of a Special Team for Online Trial Supervisors.