bluuebunny/crossref_metadata_2025 huggingface dataset:
Residual Stress Analysis of Thick Film Systems by the Incremental Hole-Drilling Method*
Authors: Held E. , Gibmeier J.
Published: April 2014

Residual stresses play an important role in coating systems as they determine their properties as well as their life-time behavior. In many industrial applications multi-layer systems are used. This work examines the applicability of the incremental hole drilling method to determine residual stress states in multi-layer coating systems, i.e. in the top-layer, in the interlayer and in the substrate. For this purpose systematic finite element (FE) simulations are carried out. Initially, the interfaces were assumed to be planar and subsequently rough interfaces were considered. The results indicate that thin interlayers with layer thicknesses smaller than 30 μm can be neglected in the evaluation of the measured strain relaxations, since they lead only to a minor stress deviation. In case of larger interlayer thicknesses a case-specific calibration, taking into account the exact build-up of the multilayer system, results in reliable determinations of the residual stress states, in the top-layer, the interlayer and the substrate. Finally the simulation results are applied to a model thick film system consisting of a thermally sprayed Al2O3-coating on a fine-grained construction steel (S690QL). Its residual stress state is determined experimentally by the incremental hole-drilling method.
Microstructure and Properties of Pearlitic Steel during Cold Wire Drawing: A Residual Stress Perspective*
Authors: Kriška M. , Tacq J. , Van Acker K. , Seefeldt M.
Published: April 2014

The residual stress evolution during cold drawing of pearlitic steel wire was followed over a broad strain range by diffraction techniques. The present work discusses possible links between microstructural changes induced by severe deformation and their “footprints” left in the residual stresses on different – macro, micro and nano – scale levels. Energy dispersive synchrotron diffraction revealed a significant divergence in the grain microstress evolution among differently oriented ferrite grains in the high deformation regime beyond an accumulated true strain of about ∊t ≥ 2.3. A possible physical reason for the observed divergence is discussed in terms of a distinct microstructure development in this stage of the cold wire drawing.
Welfare of Pigs Being Transported over Long Distances Using a Pot-Belly Trailer during Winter and Summer
Authors: Correa Jorge , Gonyou Harold , Torrey Stephanie , Widowski Tina , Bergeron Renée , Crowe Trever , Laforest Jean-Paul , Faucitano Luigi
Published: April 2014

A total of 2,145 pigs were transported for 8 h in summer (six trips) and winter (five trips) using a pot-belly trailer accommodating pigs in four locations (upper deck or UD, bottom-nose or BN, middle deck or MD and bottom deck or BD). Heart rate of pigs during loading and transportation and lactate and creatine kinase (CK) concentrations in exsanguination blood were measured. Meat quality was evaluated in the Longissimus thoracis (LT), Semimembranosus (SM) and Adductor (AD) muscles. During summer, pigs loaded in the UD and MD had higher (P < 0.05) heart rate at loading compared to those located in the BD and BN. Blood lactate and CK concentrations were higher (P < 0.001) in winter than in summer. Lactate concentration was higher (P = 0.01) in the blood of pigs transported in the BN. Pigs transported in the BN had higher pHu values in the LT, SM and AD muscles (P = 0.02, P < 0.001 and P = 0.002, respectively) and lower (P = 0.002) drip loss values in the SM muscle. This study confirms that some locations within the PB trailer have a negative impact on the welfare of pigs at loading and during transport with more pronounced effects in the winter due to the additive effect of cold stress.
Using a Risk Cost-Benefit Analysis for a Sea Dike to Adapt to the Sea Level in the Vietnamese Mekong River Delta
Authors: Danh Vo , Khai Huynh
Published: April 2014

The purpose of this study is to conduct an economic valuation of creating a concrete sea dike system as an adaptation measure to counter the impacts of a rise in sea level using a risk cost-benefit analysis framework. It uses an ex-ante approach with risk considerations for storms, floods, and salinity by specifying probability distribution functions in a simulation process, in order to incorporate these risk factors into the analysis. The results showed that the benefits of storms and floods avoided dominated the dike options. The benefit of salinity avoided was also valuable, with annual rice and aquaculture productivity losses avoided of USD 331.25 per ha and USD 915 per ha, respectively. This study evaluated a range of dike options to adapt to climate change in the Vietnamese Mekong Delta, showing high levels of benefits compared to costs. The larger in scale the dike system options were, the higher the expected net present values (ENPVs) were. Of the dike alternatives applicable to the Vietnamese Mekong Delta, considering the impacts of sea level rise of storms, floods and raised salinity in soil from flooding, small scale dikes that can subsequently be increased in height should be a priority choice. The sensitivity analyses showed that the ENPVs of dike options were very sensitive with changes in discount rate but were not sensitive with increases in salinized areas at all. The findings provide evidence to support the necessity of the construction of a concrete sea dike system in the Vietnamese Mekong Delta, given the context of global climate change.
Measuring the Complexity of Self-Organizing Traffic Lights
Authors: Zubillaga Darío , Cruz Geovany , Aguilar Luis , Zapotécatl Jorge , Fernández Nelson , Aguilar José , Rosenblueth David , Gershenson Carlos
Published: April 2014

We apply measures of complexity, emergence, and self-organization to an urban traffic model for comparing a traditional traffic-light coordination method with a self-organizing method in two scenarios: cyclic boundaries and non-orientable boundaries. We show that the measures are useful to identify and characterize different dynamical phases. It becomes clear that different operation regimes are required for different traffic demands. Thus, not only is traffic a non-stationary problem, requiring controllers to adapt constantly; controllers must also change drastically the complexity of their behavior depending on the demand. Based on our measures and extending Ashby’s law of requisite variety, we can say that the self-organizing method achieves an adaptability level comparable to that of a living system.
Fast Cut Back Thermal Power Plant Load Rejection and Black Start Field Test Analysis
Authors: Zeng Kaiwen , Wen Jinyu , Ma Longpeng , Cheng Shijie , Lu En , Wang Ning
Published: April 2014

Fast and reliable black start plays a key role in improving the ability of the power system to resist the risk of large-scale blackouts. For a black start with high voltage and long-distance transmission lines, it is much easier to cause phenomena such as self-excitation and power frequency/operating overvoltage, which may lead to black start failure and impact the reliability of the system’s restoration. Meanwhile, the long time needed to crank up the non-black start units will impact the speed of the restoration. This paper addresses the advantages of using a thermal power unit with a fast cut back (FCB) function as a black start unit, and studies the transient process of the FCB unit during the restoration. Firstly, key problems in the power system black start process are analyzed and a practical engineering criterion of self-excitation is proposed. Secondly, the dynamic model of the FCB unit is presented. Thirdly, the field test of the FCB unit load rejection and black start is introduced, which is the first successful field test of black start with 500 kV long-distance lines in China Southern Power Grid (CSG). Finally, the transient process of this test is simulated using the PSCAD/EMTDC software, and the simulation results accord well with the field test results, which verifies the correctness of the FCB model and the self-excitation engineering criterion proposed.
Crude Oil Spot Price Forecasting Based on Multiple Crude Oil Markets and Timeframes
Authors: Deng Shangkun , Sakurai Akito
Published: April 2014

This study proposes a multiple kernel learning (MKL)-based regression model for crude oil spot price forecasting and trading. We used a well-known trend-following technical analysis indicator, the moving average convergence and divergence (MACD) indicator, for extracting features from original spot prices. Additionally, we factored in the possibility that movements of target crude oil prices may be related to other important crude oil markets besides the target market for the prediction time horizon since traders may find price movement information within other relevant crude oil markets useful. We also considered multiple timeframes in this study since trends may differ across different timeframes and, in fact, traders may use their own timeframes. Therefore, for forecasting target crude oil prices, this study emphasizes on features pertaining to other important crude oil markets and different timeframes in addition to features of the target crude oil market and target timeframe. Moreover, the MKL framework has been used to fuse information extracted from different sources and timeframes of the same data source. Experimental results show that out-of-sample forecasting using the MKL method is superior to benchmark methods in terms of root mean square error (RMSE) and average percentage profit (APP). They also show that the information from multiple timeframes is useful for prediction, but that from another crude oil market is not.
Evapotranspiration Estimation with Remote Sensing and Various Surface Energy Balance Algorithms—A Review
Authors: Liou Yuei-An , Kar Sanjib
Published: April 2014

With the advent of new satellite technology, the radiative energy exchanges between Sun, Earth, and space may now be quantified accurately. Nevertheless, much less is known about the magnitude of the energy flows within the climate system and at the Earth’s surface, which cannot be directly measured by satellites. This review surveys the basic theories, observational methods, and different surface energy balance algorithms for estimating evapotranspiration (ET) from landscapes and regions with remotely sensed surface temperatures, and highlights uncertainties and limitations associated with those estimation methods. Although some of these algorithms were built up for specific land covers like irrigation areas only, methods developed for other disciplines like hydrology and meteorology, are also reviewed, where continuous estimates in space and in time are needed. Temporal and spatial scaling issues associated with the use of thermal remote sensing for estimating evapotranspiration are also discussed. A review of these different satellite based remote sensing approaches is presented. The main physical bases and assumptions of these algorithms are also discussed. Some results are shown for the estimation of evapotranspiration on a rice paddy of Chiayi Plain in Taiwan using remote sensing data.
A Survey Aimed at General Citizens of the US and Japan about Their Attitudes toward Electronic Medical Data Handling
Authors: Kimura Michio , Nakaya Jun , Watanabe Hiroshi , Shimizu Toshiro , Nakayasu Kazuyuki
Published: April 2014

Objectives: To clarify the views of the general population of two countries (US and Japan), concerning the handling of their medical records electronically. Methods: We contacted people nationwide in the United States at random via Random Digit Dialing (RDD) to obtain 200 eligible responders. The questionnaire was for obtaining the information on their attitudes towards handling of their medical records, disclosure of the name of disease, secondary usage of information, compiling their records into a lifelong medical record, and access to their medical records on the Internet. We had also surveyed people of Shizuoka prefecture in Japan using same questionnaires sent by mail, for which we obtained 457 valid answers. Results: Even in an unidentifiable manner, US people feel profit-oriented usage of medical data without specific consent is not acceptable. There is a significant difference between usage of unidentifiable medical data for profit (about 50% feel negatively) and for official/research purposes (about 30% feel negatively). About 60% of the US responders have a negative view on the proposal that unidentifiable medical information be utilized for profit by private companies to attain healthcare cost savings. As regards compiling a lifelong medical record, positive answers and negative answers are almost equally divided in the US (46% vs. 38%) while more positive attitudes are seen in Japan (74% vs. 12%). However, any incentive measures aimed at changing attitudes to such a compiling including the discount of healthcare costs or insurance fees are unwelcomed by people regardless of their age or health condition in both surveys. Regarding the access to their own medical record via the Internet, 38% of the US responders feel this is unacceptable while 50.5% were willing to accept it. Conclusions: Participants from the US think that the extent of the sharing their identifiable medical records should be limited to the doctors-in-charge and specified doctors referred to by their own doctors. On the other hand, Japanese people find it acceptable for doctors of the same hospital to share their medical records. Even in unidentifiable manner, people in both countries think the profits resulting from the secondary use of medical records should be returned to the public or patients. With regard to compiling a lifelong medical record, participants from the US provided both positive answers and negative answers, while more positive attitudes were observed in Japan. However, any incentives or measures aimed at changing attitudes towards such a compilation, including provision of a discount on healthcare costs or insurance fees, were not welcomed by participants from US as well as those from Japan, regardless of their age or health condition.
Behavioural Change, Indoor Air Pollution and Child Respiratory Health in Developing Countries: A Review
Authors: Barnes Brendon
Published: April 2014

Indoor air pollution caused by the indoor burning of solid biomass fuels has been associated with Acute Respiratory Infections such as pneumonia amongst children of less than five years of age. Behavioural change interventions have been identified as a potential strategy to reduce child indoor air pollution exposure, yet very little is known about the impact of behavioural change interventions to reduce indoor air pollution. Even less is known about how behaviour change theory has been incorporated into indoor air pollution behaviour change interventions. A review of published studies spanning 1983–2013 suggests that behavioural change strategies have the potential to reduce indoor air pollution exposure by 20%–98% in laboratory settings and 31%–94% in field settings. However, the evidence is: (1) based on studies that are methodologically weak; and (2) have little or no underlying theory. The paper concludes with a call for more rigorous studies to evaluate the role of behavioural change strategies (with or without improved technologies) to reduce indoor air pollution exposure in developing countries as well as interventions that draw more strongly on existing behavioural change theory and practice.
SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma
Authors: Li Chao , Yang Wei , Zhang Junli , Zheng Xin , Yao Yingmin , Tu Kangsheng , Liu Qingguang
Published: April 2014

Sterol regulatory element-binding protein 1 (SREBP-1) is a well-known nuclear transcription factor involved in lipid synthesis. Recent studies have focused on its functions in tumor cell proliferation and apoptosis, but its role in cell migration and invasion, especially in hepatocellular carcinoma (HCC), is still unclear. In this study, we found that the expression of SREBP-1 in HCC tissues was significantly higher than those in matched tumor-adjacent tissues (p < 0.05). SREBP-1 was expressed at significantly higher levels in patients with large tumor size, high histological grade and advanced tumor-node-metastasis (TNM) stage (p < 0.05). The positive expression of SREBP-1 correlated with a worse 3-year overall and disease-free survival of HCC patients (p < 0.05). Additionally, SREBP-1 was an independent factor for predicting both 3-year overall and disease-free survival of HCC patients (p < 0.05). In vitro studies revealed that downregulation of SREBP-1 inhibited cell proliferation and induced apoptosis in both HepG2 and MHCC97L cells (p < 0.05). Furthermore, wound healing and transwell assays showed that SREBP-1 knockdown prominently inhibited cell migration and invasion in both HepG2 and MHCC97L cells (p < 0.05). These results suggest that SREBP-1 may serve as a prognostic marker in HCC and may promote tumor progression by promoting cell growth and metastasis.
Generation of Bladder Urothelium from Human Pluripotent Stem Cells under Chemically Defined Serum- and Feeder-Free System
Authors: Kang Minyong , Kim Hyeon , Han Yong-Mahn
Published: April 2014

Human stem cells are promising sources for bladder regeneration. Among several possible sources, pluripotent stem cells are the most fascinating because they can differentiate into any cell type, and proliferate limitlessly in vitro. Here, we developed a protocol for differentiation of human pluripotent stem cells (hPSCs) into bladder urothelial cells (BUCs) under a chemically defined culture system. We first differentiated hPSCs into definitive endoderm (DE), and further specified DE cells into BUCs by treating retinoic acid under a keratinocyte-specific serum free medium. hPSC-derived DE cells showed significantly expressed DE-specific genes, but did not express mesodermal or ectodermal genes. After DE cells were specified into BUCs, they notably expressed urothelium-specific genes such as UPIb, UPII, UPIIIa, P63 and CK7. Immunocytochemistry showed that BUCs expressed UPII, CK8/18 and P63 as well as tight junction molecules, E-CADHERIN and ZO-1. Additionally, hPSCs-derived BUCs exhibited low permeability in a FITC-dextran permeability assay, indicating BUCs possessed the functional units of barrier on their surfaces. However, BUCs did not express the marker genes of other endodermal lineage cells (intestine and liver) as well as mesodermal or ectodermal lineage cells. In summary, we sequentially differentiated hPSCs into DE and BUCs in a serum- and feeder-free condition. Our differentiation protocol will be useful for producing cells for bladder regeneration and studying normal and pathological development of the human bladder urothelium in vitro.
Nanoinformatics: Emerging Databases and Available Tools
Authors: Panneerselvam Suresh , Choi Sangdun
Published: April 2014

Nanotechnology has arisen as a key player in the field of nanomedicine. Although the use of engineered nanoparticles is rapidly increasing, safety assessment is also important for the beneficial use of new nanomaterials. Considering that the experimental assessment of new nanomaterials is costly and laborious, in silico approaches hold promise. Several major challenges in nanotechnology indicate a need for nanoinformatics. New database initiatives such as ISA-TAB-Nano, caNanoLab, and Nanomaterial Registry will help in data sharing and developing data standards, and, as the amount of nanomaterials data grows, will provide a way to develop methods and tools specific to the nanolevel. In this review, we describe emerging databases and tools that should aid in the progress of nanotechnology research.
Simultaneous Microwave Extraction and Separation of Volatile and Non-Volatile Organic Compounds of Boldo Leaves. From Lab to Industrial Scale
Authors: Petigny Loïc , Périno Sandrine , Minuti Matteo , Visinoni Francesco , Wajsman Joël , Chemat Farid
Published: April 2014

Microwave extraction and separation has been used to increase the concentration of the extract compared to the conventional method with the same solid/liquid ratio, reducing extraction time and separate at the same time Volatile Organic Compounds (VOC) from non-Volatile Organic Compounds (NVOC) of boldo leaves. As preliminary study, a response surface method has been used to optimize the extraction of soluble material and the separation of VOC from the plant in laboratory scale. The results from the statistical analysis revealed that the optimized conditions were: microwave power 200 W, extraction time 56 min and solid liquid ratio of 7.5% of plants in water. Lab scale optimized microwave method is compared to conventional distillation, and requires a power/mass ratio of 0.4 W/g of water engaged. This power/mass ratio is kept in order to upscale from lab to pilot plant.
The Association of Il28b Genotype with the Histological Features of Chronic Hepatitis C Is HCV Genotype Dependent
Authors: D'Ambrosio Roberta , Aghemo Alessio , De Francesco Raffaele , Rumi Maria , Galmozzi Enrico , De Nicola Stella , Cheroni Cristina , Clark Paul , Ronchi Guido , Lampertico Pietro , Colombo Massimo
Published: April 2014

The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as <5% or ≥5%. IL28B was typed by Taqman Single Nucleotide Polymorphism (SNP) genotyping assay. HCV genotype was 1 in 151 (45%), 2 in 99 (30%), 3 in 50 (15%) and 4 in 35 (10%) patients. IL28B genotype was CC in 117 (34%), CT in 166 (49%) and TT in 52 (15%). At univariate analysis, the IL28B CC genotype was associated with severe portal inflammation in HCV-1 patients (CC vs. CT/TT: 86% vs. 63%, p = 0.005), severe lobular inflammation in HCV-2 patients (CC vs. CT/TT: 44% vs. 23%, p = 0.03), and less fatty infiltration in HCV-1 patients (CC vs. CT/TT: 72% vs. 51%, p = 0.02). Despite the lack of any association between IL28B and fibrosis stage, in HCV-3 patients IL28B CC correlated with METAVIR F3-F4 (CC vs. CT/TT: 74% vs. 26%, p = 0.05). At multivariate analysis, the genotype CC remained associated with severe portal inflammation in HCV-1, only (Odds Ratio (OR): 95% Confidence Interval (CI): 3.24 (1.23–8.51)). IL28B genotype is associated with the histological features of chronic hepatitis C in a HCV genotype dependent manner, with CC genotype being independently associated with severe portal inflammation.
Indian Hedgehog in Synovial Fluid Is a Novel Marker for Early Cartilage Lesions in Human Knee Joint
Authors: Zhang Congming , Wei Xiaochun , Chen Chongwei , Cao Kun , Li Yongping , Jiao Qiang , Ding Juan , Zhou Jingming , Fleming Braden , Chen Qian , Shang Xianwen , Wei Lei
Published: April 2014

To determine whether there is a correlation between the concentration of Indian hedgehog (Ihh) in synovial fluid (SF) and the severity of cartilage damage in the human knee joints, the knee cartilages from patients were classified using the Outer-bridge scoring system and graded using the Modified Mankin score. Expression of Ihh in cartilage and SF samples were analyzed with immunohistochemistry (IHC), western blot, and enzyme-linked immunosorbent assay (ELISA). Furthermore, we detected and compared Ihh protein levels in rat and mice cartilages between normal control and surgery-induced osteoarthritis (OA) group by IHC and fluorescence molecular tomography in vivo respectively. Ihh expression was increased 5.2-fold in OA cartilage, 3.1-fold in relative normal OA cartilage, and 1.71-fold in OA SF compared to normal control samples. The concentrations of Ihh in cartilage and SF samples was significantly increased in early-stage OA samples when compared to normal samples (r = 0.556; p < 0.001); however, there were no significant differences between normal samples and late-stage OA samples. Up-regulation of Ihh protein was also an early event in the surgery-induced OA models. Increased Ihh is associated with the severity of OA cartilage damage. Elevated Ihh content in human knee joint synovial fluid correlates with early cartilage lesions.
Proteomic Study of Differential Protein Expression in Mouse Lung Tissues after Aerosolized Ricin Poisoning
Authors: Guo Zhendong , Han Chao , Du Jiajun , Zhao Siyan , Fu Yingying , Zheng Guanyu , Sun Yucheng , Zhang Yi , Liu Wensen , Wan Jiayu , Qian Jun , Liu Linna
Published: April 2014

Ricin is one of the most poisonous natural toxins from plants and is classified as a Class B biological threat pathogen by the Centers for Disease Control and Prevention (CDC) of U.S.A. Ricin exposure can occur through oral or aerosol routes. Ricin poisoning has a rapid onset and a short incubation period. There is no effective treatment for ricin poisoning. In this study, an aerosolized ricin-exposed mouse model was developed and the pathology was investigated. The protein expression profile in the ricin-poisoned mouse lung tissue was analyzed using proteomic techniques to determine the proteins that were closely related to the toxicity of ricin. 2D gel electrophoresis, mass spectrometry and subsequent biological functional analysis revealed that six proteins including Apoa1 apolipoprotein, Ywhaz 14-3-3 protein, Prdx6 Uncharacterized Protein, Selenium-binding protein 1, HMGB1, and DPYL-2, were highly related to ricin poisoning.
Genome-Wide Identification, 3D Modeling, Expression and Enzymatic Activity Analysis of Cell Wall Invertase Gene Family from Cassava (Manihot esculenta Crantz)
Authors: Yao Yuan , Geng Meng-Ting , Wu Xiao-Hui , Liu Jiao , Li Rui-Mei , Hu Xin-Wen , Guo Jian-Chun
Published: April 2014

The cell wall invertases play a crucial role on the sucrose metabolism in plant source and sink organs. In this research, six cell wall invertase genes (MeCWINV1-6) were cloned from cassava. All the MeCWINVs contain a putative signal peptide with a predicted extracellular location. The overall predicted structures of the MeCWINV1-6 are similar to AtcwINV1. Their N-terminus domain forms a β-propeller module and three conserved sequence domains (NDPNG, RDP and WECP(V)D), in which the catalytic residues are situated in these domains; while the C-terminus domain consists of a β-sandwich module. The predicted structure of Pro residue from the WECPD (MeCWINV1, 2, 5, and 6), and Val residue from the WECVD (MeCWINV3 and 4) are different. The activity of MeCWINV1 and 3 were higher than other MeCWINVs in leaves and tubers, which suggested that sucrose was mainly catalyzed by the MeCWINV1 and 3 in the apoplastic space of cassava source and sink organs. The transcriptional levels of all the MeCWINVs and their enzymatic activity were lower in tubers than in leaves at all the stages during the cassava tuber development. It suggested that the major role of the MeCWINVs was on the regulation of carbon exportation from source leaves, and the ratio of sucrose to hexose in the apoplasts; the role of these enzymes on the sucrose unloading to tuber was weaker.
Optimization of Squeeze Casting Parameters for 2017 A Wrought Al Alloy Using Taguchi Method
Authors: Souissi Najib , Souissi Slim , Niniven Christophe , Amar Mohamed , Bradai Chedly , Elhalouani Foued
Published: April 2014

This study applies the Taguchi method to investigate the relationship between the ultimate tensile strength, hardness and process variables in a squeeze casting 2017 A wrought aluminium alloy. The effects of various casting parameters including squeeze pressure, melt temperature and die temperature were studied. Therefore, the objectives of the Taguchi method for the squeeze casting process are to establish the optimal combination of process parameters and to reduce the variation in quality between only a few experiments. The experimental results show that the squeeze pressure significantly affects the microstructure and the mechanical properties of 2017 A Al alloy.
Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives
Authors: Rashad Aymn , Shamroukh Ahmed , Abdel-Megeid Randa , Ali Hatem
Published: April 2014

4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described.
Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)
Authors: Nwodo Ngozi , Okoye Festus , Lai Daowan , Debbab Abdessamad , Brun Reto , Proksch Peter
Published: April 2014

Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of the crude extract. In this study, two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extract of Zapoteca portoricensis and their chemical structures deduced by one dimensional and two dimensional NMR and mass spectrometry. These compounds were isolated for the first time from this plant, and no report has been found on their previous isolation from the genus Zapoteca. Evaluation of their trypanocidal activity showed that compound 1 exhibited potent activity against Trypanosoma brucei rhodesiense with an IC50 value of 3.63 μM and selectivity index of 25.3.
Damage Mapping of Powdery Mildew in Winter Wheat with High-Resolution Satellite Image
Authors: Yuan Lin , Zhang Jingcheng , Shi Yeyin , Nie Chenwei , Wei Liguang , Wang Jihua
Published: April 2014

Powdery mildew, caused by the fungus Blumeria graminis, is a major winter wheat disease in China. Accurate delineation of powdery mildew infestations is necessary for site-specific disease management. In this study, high-resolution multispectral imagery of a 25 km2 typical outbreak site in Shaanxi, China, taken by a newly-launched satellite, SPOT-6, was analyzed for mapping powdery mildew disease. Two regions with high representation were selected for conducting a field survey of powdery mildew. Three supervised classification methods—artificial neural network, mahalanobis distance, and maximum likelihood classifier—were implemented and compared for their performance on disease detection. The accuracy assessment showed that the ANN has the highest overall accuracy of 89%, following by MD and MLC with overall accuracies of 84% and 79%, respectively. These results indicated that the high-resolution multispectral imagery with proper classification techniques incorporated with the field investigation can be a useful tool for mapping powdery mildew in winter wheat.
Critical Metadata for Spectroscopy Field Campaigns
Authors: Rasaiah Barbara , Jones Simon. , Bellman Chris , Malthus Tim
Published: April 2014

A field spectroscopy metadata standard is defined as those data elements that explicitly document the spectroscopy dataset and field protocols, sampling strategies, instrument properties and environmental and logistical variables. Standards for field spectroscopy metadata affect the quality, completeness, reliability, and usability of datasets created in situ. Currently there is no standardized methodology for documentation of in situ spectroscopy data or metadata. This paper presents results of an international experiment comprising a web-based survey and expert panel evaluation that investigated critical metadata in field spectroscopy. The survey participants were a diverse group of scientists experienced in gathering spectroscopy data across a wide range of disciplines. Overall, respondents were in agreement about a core metadataset for generic campaign metadata, allowing for a prioritization of critical metadata elements to be proposed including those relating to viewing geometry, location, general target and sampling properties, illumination, instrument properties, reference standards, calibration, hyperspectral signal properties, atmospheric conditions, and general project details. Consensus was greatest among individual expert groups in specific application domains. The results allow the identification of a core set of metadata fields that enforce long term data storage and serve as a foundation for a metadata standard. This paper is part one in a series about the core elements of a robust and flexible field spectroscopy metadata standard.
Land Cover Classification for Polarimetric SAR Images Based on Mixture Models
Authors: Gao Wei , Yang Jian , Ma Wenting
Published: April 2014

In this paper, two mixture models are proposed for modeling heterogeneous regions in single-look and multi-look polarimetric SAR images, along with their corresponding maximum likelihood classifiers for land cover classification. The classical Gaussian and Wishart models are suitable for modeling scattering vectors and covariance matrices from homogeneous regions, while their performance deteriorates for regions that are heterogeneous. By comparison, the proposed mixture models reduce the modeling error by expressing the data distribution as a weighted sum of multiple component distributions. For single-look and multi-look polarimetric SAR data, complex Gaussian and complex Wishart components are adopted, respectively. Model parameters are determined by employing the expectation-maximization (EM) algorithm. Two maximum likelihood classifiers are then constructed based on the proposed mixture models. These classifiers are assessed using polarimetric SAR images from the RADARSAT-2 sensor of the Canadian Space Agency (CSA), the AIRSAR sensor of the Jet Propulsion Laboratory (JPL) and the EMISAR sensor of the Technical University of Denmark (DTU). Experiment results demonstrate that the new models fit heterogeneous regions preferably to the classical models and are especially appropriate for extremely heterogeneous regions, such as urban areas. The overall accuracy of land cover classification is also improved due to the more refined modeling.
Data Transformation Functions for Expanded Search Spaces in Geographic Sample Supervised Segment Generation
Authors: Fourie Christoff , Schoepfer Elisabeth
Published: April 2014

Sample supervised image analysis, in particular sample supervised segment generation, shows promise as a methodological avenue applicable within Geographic Object-Based Image Analysis (GEOBIA). Segmentation is acknowledged as a constituent component within typically expansive image analysis processes. A general extension to the basic formulation of an empirical discrepancy measure directed segmentation algorithm parameter tuning approach is proposed. An expanded search landscape is defined, consisting not only of the segmentation algorithm parameters, but also of low-level, parameterized image processing functions. Such higher dimensional search landscapes potentially allow for achieving better segmentation accuracies. The proposed method is tested with a range of low-level image transformation functions and two segmentation algorithms. The general effectiveness of such an approach is demonstrated compared to a variant only optimising segmentation algorithm parameters. Further, it is shown that the resultant search landscapes obtained from combining mid- and low-level image processing parameter domains, in our problem contexts, are sufficiently complex to warrant the use of population based stochastic search methods. Interdependencies of these two parameter domains are also demonstrated, necessitating simultaneous optimization.
The First Electrochemical MIP Sensor for Tamoxifen
Authors: Yarman Aysu , Scheller Frieder
Published: April 2014

We present an electrochemical MIP sensor for tamoxifen (TAM)—a nonsteroidal anti-estrogen—which is based on the electropolymerisation of an O-phenylenediamine‒resorcinol mixture directly on the electrode surface in the presence of the template molecule. Up to now only “bulk” MIPs for TAM have been described in literature, which are applied for separation in chromatography columns. Electro-polymerisation of the monomers in the presence of TAM generated a film which completely suppressed the reduction of ferricyanide. Removal of the template gave a markedly increased ferricyanide signal, which was again suppressed after rebinding as expected for filling of the cavities by target binding. The decrease of the ferricyanide peak of the MIP electrode depended linearly on the TAM concentration between 1 and 100 nM. The TAM-imprinted electrode showed a 2.3 times higher recognition of the template molecule itself as compared to its metabolite 4-hydroxytamoxifen and no cross-reactivity with the anticancer drug doxorubucin was found. Measurements at +1.1 V caused a fouling of the electrode surface, whilst pretreatment of TAM with peroxide in presence of HRP generated an oxidation product which was reducible at 0 mV, thus circumventing the polymer formation and electrochemical interferences.
An Uncertainty-Based Distributed Fault Detection Mechanism for Wireless Sensor Networks
Authors: Yang Yang , Gao Zhipeng , Zhou Hang , Qiu Xuesong
Published: April 2014

Exchanging too many messages for fault detection will cause not only a degradation of the network quality of service, but also represents a huge burden on the limited energy of sensors. Therefore, we propose an uncertainty-based distributed fault detection through aided judgment of neighbors for wireless sensor networks. The algorithm considers the serious influence of sensing measurement loss and therefore uses Markov decision processes for filling in missing data. Most important of all, fault misjudgments caused by uncertainty conditions are the main drawbacks of traditional distributed fault detection mechanisms. We draw on the experience of evidence fusion rules based on information entropy theory and the degree of disagreement function to increase the accuracy of fault detection. Simulation results demonstrate our algorithm can effectively reduce communication energy overhead due to message exchanges and provide a higher detection accuracy ratio.
Socio-Economic Inequality, Human Trafficking, and the Global Slave Trade
Authors: Barner John , Okech David , Camp Meghan
Published: April 2014

The purpose of this paper is to discuss human trafficking within the broader framework of socio-economic inequality. The presence of socio-economic inequality in the world creates a system where those in power very easily dominate and take advantage of those people without power. One of the most serious contemporary effects of inequalities between and within nations is the phenomenon of global sex trade or human trafficking for the purposes of sex. Deriving from unequal power relations, human trafficking is a serious global crime that involves the exploitation of many, but mostly females and children. This paper provides an extensive discussion of inequality and its links with human trafficking as contemporary slavery. In conclusion, the paper provides a list of selected intra-national and multi-national service organizations that are adopting strategies for combating trafficking through the reduction of social and economic inequality. Implications for social welfare advocates and international collaborative efforts are highlighted.
A Point Source of a Different Color: Identifying a Gap in United States Regulatory Policy for “Green” CSO Treatment Using Constructed Wetlands
Authors: Levy Zeno , Smardon Richard , Bays James , Meyer Daniel
Published: April 2014

Up to 850 billion gallons of untreated combined sewer overflow (CSO) is discharged into waters of the United States each year. Recent changes in CSO management policy support green infrastructure (GI) technologies as “front of the pipe” approaches to discharge mitigation by detention/reduction of urban stormwater runoff. Constructed wetlands for CSO treatment have been considered among suites of GI solutions. However, these wetlands differ fundamentally from other GI technologies in that they are “end of the pipe” treatment systems that discharge from a point source, and are therefore regulated in the U.S. under the National Pollution Discharge Elimination System (NPDES). We use a comparative regulatory analysis to examine the U.S. policy framework for CSO treatment wetlands. We find in all cases that permitting authorities have used best professional judgment to determine effluent limits and compliance monitoring requirements, referencing technology and water quality-based standards originally developed for traditional “grey” treatment systems. A qualitative comparison with Europe shows less stringent regulatory requirements, perhaps due to institutionalized design parameters. We recommend that permitting authorities develop technical guidance documents for evaluation of “green” CSO treatment systems that account for their unique operational concerns and benefits with respect to sustainable development.
Sustainability Study on Heavy Metal Uptake in Neem Biodiesel Using Selective Catalytic Preparation and Hyphenated Mass Spectrometry
Authors: Elkadi Mirella , Pillay Avin , Manuel Johnson , Khan Mohammad , Stephen Sasi , Molki Arman
Published: April 2014

It is common knowledge that the presence of trace metals in biofuels can be detrimental to the environment and long-term sustainable development. This study provides an insight into selective catalytic preparation of biofuel to compare uptake of trace metals in the biodiesel fraction with preferential base catalysts. The role of specific metal hydroxides in controlling trace metal content in biofuel production is relatively unexplored, and the effect of different homogeneous catalysts (NaOH, KOH) on metal retention in biodiesel from commercial neem oil was examined. A detailed study of this nature of catalyst vs. metal uptake is in the interest of sustainable living and could make a significant contribution to biofuels research. Both catalysts displayed variable uptake for certain toxic elements, which was attributed to the behavior of the catalyst in the reaction mixture. A general comparison reflected specific trends in metal retention (ICP-MS) with the use of different base catalysts. Challenges encountered by extending the study and using a heterogeneous catalyst (CaO) are presented. Our work could play a significant role in influencing catalyzed transesterfication processes to control elemental and toxic metal uptake in biofuels. The impact of our work on sustainable living is presented.
Sustainability of Domestic Sewage Sludge Disposal
Authors: Rizzardini Claudia , Goi Daniele
Published: April 2014

Activated sludge is now one of the most widely used biological processes for the treatment of wastewaters from medium to large populations. It produces high amounts of sewage sludge that can be managed and perceived in two main ways: as a waste it is discharged in landfill, as a fertilizer it is disposed in agriculture with direct application to soil or subjected to anaerobic digestion and composting. Other solutions, such as incineration or production of concrete, bricks and asphalt play a secondary role in terms of their degree of diffusion. The agronomical value of domestic sewage sludge is a proved question, which may be hidden by the presence of several pollutants such as heavy metals, organic compounds and pathogens. In this way, the sustainability of sewage sludge agricultural disposal requires a value judgment based on knowledge and evaluation of the level of pollution of both sewage sludge and soil. The article analyzed a typical Italian case study, a water management system of small communities, applying the criteria of evaluation of the last official document of European Union about sewage sludge land application, the “Working Document on Sludge (3rd draft, 2000)”. The report brought out good sewage sludge from small wastewater treatment plants and soils quality suggesting a sustainable application.
Use of GIS Tools for Environmental Conflict Resolution at Map Ta Phut Industrial Zone in Thailand
Authors: Soytong Phattraporn , Perera Ranjith
Published: April 2014

Special industrial zones are favored over scattered industries from an environmental management perspective, but poor management can lead to conflicts. This paper presents an analysis of the environmental conflict that arose between the state, society, and industry stakeholders in an industrial zone of the Eastern Seaboard Development Program of Thailand. This paper seeks to determine the effectiveness of policy measures implemented by the state to resolve the conflict. The purpose of this study is to draw lessons for industrializing nations that adopt the industrial zone model to foster environmentally sustainable industrial development. The study revealed that blatant violation of land-use planning regulations and expansion of the industrial zone into community areas was a root cause of the conflict. Through legal action, civil society has been successful in forcing the state and industries to halt unplanned expansion of industrial areas and practice better environmental governance. However, inadequate commitment by the state and industry stakeholders seems to perpetuate the conflict, threatening the sustainability of economic gains. A Geographic Information Systems (GIS)-based analysis confirmed that the policy interventions of the government to resolve the conflict have not produced significant results. This paper highlights the need for GIS-based environmental quality monitoring for guiding industrialization-based urban development towards sustainability.
A Sceptics View: “Kleiber’s Law” or the “3/4 Rule” is neither a Law nor a Rule but Rather an Empirical Approximation
Authors: Hulbert A.
Published: April 2014

Early studies showed the metabolic rate (MR) of different-sized animals was not directly related to body mass. The initial explanation of this difference, the “surface law”, was replaced by the suggestion that MR be expressed relative to massn, where the scaling exponent “n” be empirically determined. Basal metabolic rate (BMR) conditions were developed and BMR became important clinically, especially concerning thyroid diseases. Allometry, the technique previously used to empirically analyse relative growth, showed BMR of endotherms varied with 0.73–0.74 power of body mass. Kleiber suggested that mass3/4 be used, partly because of its easy calculation with a slide rule. Later studies have produced a range of BMR scaling exponents, depending on species measured. Measurement of maximal metabolism produced scaling exponents ranging from 0.80 to 0.97, while scaling of mammalian MR during growth display multi-phasic allometric relationships with scaling exponents >3/4 initially, followed by scaling exponents <3/4. There is no universal metabolic scaling exponent. The fact that “allometry” is an empirical technique to analyse relative change and not a biological law is discussed. Relative tissue size is an important determinant of MR. There is also a need to avoid simplistic assumptions regarding the allometry of surface area.