bluuebunny/crossref_metadata_2025 huggingface dataset:
RepE: unsupervised representation learning for image enhancement in nonlinear optical microscopy
Authors: Jhang Yun-Jie , Lin Xin , Chia Shih-Hsuan , Chen Wei-Chung , Wu I-Chen , Wu Ming-Tsang , Zhuo Guan-Yu , Tai Tsung-Ming , Chen Hung-Wen
Published: July 2023

We present an unsupervised learning denoising method, RepE (representation and enhancement), designed for nonlinear optical microscopy images, such as second harmonic generation (SHG) and two-photon fluorescence (TPEF). Addressing the challenge of effectively denoising images with various noise types, RepE employs an encoder network to learn noise-free representations and a reconstruction network to generate denoised images. It offers several key advantages, including its ability to (i) operate without restrictive statistic assumptions, (ii) eliminate the need for clean-noisy pairs, and (iii) requires only a few training images. Comparative evaluations on real-world SHG and TPEF images from esophageal cancer tissue slides (ESCC) demonstrate that our method outperforms existing techniques in image quality metrics. The proposed method provides a practical, robust solution for denoising nonlinear optical microscopy images, and it has the potential to be extended to other nonlinear optical microscopy modalities.
Hypergraph partitioning using tensor eigenvalue decomposition
Authors: Maurya Deepak , Ravindran Balaraman
Published: July 2023

Hypergraphs have gained increasing attention in the machine learning community lately due to their superiority over graphs in capturingsuper-dyadicinteractions among entities. In this work, we propose a novel approach for the partitioning ofk-uniform hypergraphs. Most of the existing methods work by reducing the hypergraph to a graph followed by applying standard graph partitioning algorithms. The reduction step restricts the algorithms to capturing only some weighted pairwise interactions and hence loses essential information about the original hypergraph. We overcome this issue by utilizingtensor-based representation of hypergraphs, which enables us to capture actual super-dyadic interactions. We extend the notion of minimum ratio-cut and normalized-cut from graphs to hypergraphs and show that the relaxed optimization problem can be solved using eigenvalue decomposition of the Laplacian tensor. This novel formulation also enables us to remove a hyperedge completely by using the “hyperedge score” metric proposed by us, unlike the existing reduction approaches. We propose a hypergraph partitioning algorithm inspired from spectral graph theory and also derive a tighter upper bound on the minimum positive eigenvalue of even-order hypergraph Laplacian tensor in terms of its conductance, which is utilized in the partitioning algorithm to approximate the normalized cut. The efficacy of the proposed method is demonstrated numerically on synthetic hypergraphs generated by stochastic block model. We also show improvement for the min-cut solution on 2-uniform hypergraphs (graphs) over the standard spectral partitioning algorithm.
Evaluating the solubility of compounds intended for intramammary infusion based upon tests conducted across a range of milk matrices
Authors: Martinez Marilyn N. , Zhao Fang , Longstaff David G. , Gabriel Justin J. , Coffey Martin J.
Published: July 2023

The ability to evaluate drug solubility in milk and milk-related products has relevance both to human and veterinary medicine. Model compounds explored in a previous investigation focused on drug solubility assessments when delivered in milk-associated vehicles for administration to human patients. In the current investigation, we focus on the solubility of drugs intended for delivery via intramammary infusion to cattle. Because there are logistic challenges typically associated with obtaining raw milk samples for these tests, there is a need to determine potential alternative media as a substitute for raw bovine milk. Given the complexity of the milk matrix, aqueous media do not reflect the range of factors that could impact these solubility assessments. This led to the current effort to explore the magnitude of differences that might occur when substituting raw bovine milk with off-the-shelf milk products such as whole milk, skim milk, or reconstituted whole milk powder. We considered conclusions based upon the solubility assessments derived from the use of the model compounds studied in our previous report and compared them to conclusions obtained when testing two drugs with differing physicochemical characteristics that are approved for administration via bovine intramammary infusion: cephapirin benzathine and cephapirin sodium. Based upon these results, we recommend that whole milk or reconstituted whole milk can substitute for bovine raw milk for the solubility assessment of compounds intended for administration via intramammary infusion. However, unlike the human drug situation, these tests should be conducted at 38°C.
Fuzzy comprehensive evaluation and quantitative weight analysis in structure management of human resources
Authors: Zhang Hui
Published: July 2023

This research delves into the application effects of Fuzzy Comprehensive Evaluation (FCE) and quantitative weight analysis in the structure management of human resources (SMHR) to optimize the structure management. The research begins by analyzing the existing problems in SMHR, such as incomplete performance feedback and error-prone outsourcing decisions. By leveraging human resource management (HRM) characteristics, the researchers construct the SMHR evaluation index system. The Analytical Hierarchy Process (AHP) is employed to establish a hierarchical human resource structure model to determine the relative weight of each HRM indicator. Subsequently, the FCE method is utilized to build an SMHR optimization model, which is then scrutinized and assessed by means of an example. The findings indicate that the consistency ratio (C.R.) values of the first and second-level evaluation factors of the constructed model are less than 0.1, thus passing the consistency test and demonstrating credibility. Ultimately, the research effectively grades SMHR in the enterprise through the analysis of HRM optimization. Accordingly, this research presents a set of optimization suggestions and measures, including the establishment of a professional HRM operation team, acceleration of the construction of a professional talent team, enhancement of the intelligent level of the HRM center, and transition towards digital sharing. These proposed measures can serve as valuable experimental references for the optimization and improvement of HRM structures in future enterprises.
Stress-Dependent Behavior of Lightly Stabilized Industrial Waste Subbase Using Falling Weight Deflectometer
Authors: Bakare Mayuresh Dhanraj , Shahu Jagdish Telangrao , Patel Satyajit
Published: July 2023

Pavement layers exhibit stress-dependent behavior, characterized by using a laboratory resilient modulus (Mr) test. However, the field behavior of such materials seldom matches with the laboratory because of changes in the state of stress, material matrix, and loading patterns. In this study, the nonlinear behaviors of three innovative fly ash-based lightly stabilized industrial waste mixes that are proposed to replace the granular subbase of flexible pavement are characterized and compared in the laboratory and field for the first time. Nine full-scale pavement test sections were constructed with three varying thicknesses of waste mix subbase layers, namely, fly ash +  5 % lime (FAL), 70 % copper slag +  30 % fly ash (CFA) and 80 % fly ash +  20 % granulated blast furnace slag (FAG). Repeated load triaxial tests on lab samples and multiload falling weight deflectometer (FWD) tests (40 kN, 55 kN and 70 kN) on test sections conducted for three years post-construction were used to extract the nonlinear behavior of Mr and the FWD backcalculated modulus (EFWD) of subbase layers. Effects of curing and traffic damage on the nonlinear parameters of EFWD were investigated. Stress-dependent conversion factors based on two different constitutive models were established to convert Mr to EFWD at different points of the subbase service life. Stabilized waste mixes exhibited stress hardening with increasing bulk and deviatoric stresses both in the field and laboratory. Curing increased EFWD and reduced the effect of stresses on the EFWD. In contrast, traffic damage imparted the opposite effect, as the stabilized waste mixes transformed into a cracked and blocky mass. The results of this study will allow practitioners to predict the field performance of waste mix subbase with great accuracy, resulting in a reliable design and possible cost savings.
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing
Authors: Michanski Susann , Kapoor Rohan , Steyer Anna M , Möbius Wiebke , Früholz Iris , Ackermann Frauke , Gültas Mehmet , Garner Craig C , Hamra F Kent , Neef Jakob , Strenzke Nicola , Moser Tobias , Wichmann Carolin
Published: July 2023

Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization is essential for sound encoding and is attributed to a distinct molecular machinery with unique players or splice variants compared to conventional neuronal synapses. Among these is the active zone (AZ) scaffold protein piccolo/aczonin, which is represented by its short splice variant piccolino at cochlear and retinal ribbon synapses. While the function of piccolo at synapses of the central nervous system has been intensively investigated, the role of piccolino at IHC synapses remains unclear. In this study, we characterize the structure and function of IHC synapses in piccolo gene‐trap mutant rats (Pclogt/gt). We find a mild hearing deficit with elevated thresholds and reduced amplitudes of auditory brainstem responses. Ca2+channel distribution and ribbon morphology are altered in apical IHCs, while their presynaptic function seems to be unchanged. We conclude that piccolino contributes to the AZ organization in IHCs and is essential for normal hearing.
KEARIFAN LOKAL TRADISI MANDO’A PUSARO DI KECAMATAN SUNGAI SARIK, KABUPATEN PADANG PARIAMAN, SUMATRA BARAT
Authors: Putra Johan Septian , Putri Nia Ardianti
Published: July 2023

Penelitian ini bertujuan untuk menginterpretasikan nilai simbolik tradisi Mandoa Pusaro masyarakat Sungai Sarik, Kabupaten Padang Pariaman, Sumatra Barat. Penelitian dilakukan dengan pendekatan kualitatif. Data-data dikumpulkan melalui observasi, wawancara, dokumentasi. Data dianalisis dengan teknik analisis data yaitu reduksi data, penyajian data, dan konklusi. Hasil penelitian dapat diberikan kesimpulan yaitu: Pertama, ritual tradisi Mandoa Pusaro memiliki makna nilai sakralitas dan nilai religiusitas yang tinggi terhadap kepercayaan bagi masyarakat yang melaksanakannya, khususnya memberikan nilai keberkahan hidup dengan limpahan rezeki. Kedua, makam memiliki fungsi sebagai pembangkit spiritual mereka dalam menjalankan kehidupan mereka, sekaligus fungsi nilai kekerabatan bagi mereka.
MALE ROMANCE FORMULA IN FORREST GUMP MOVIE (1994)
Authors: Rutsyamsun Vidi , Awaludin Lili
Published: July 2023

This journal investigates how Forrest Gump's portrayal of disability in romantic relationships. To investigate how the main character, Forrest Gump, and his partner, Jenny, encountered difficulties in forging a love relationship because of Forrest's disabilities, the researcher employed a qualitative technique with a narrative analytic method. The study sought to investigate how the movie deals with disability difficulties while presenting the ideal romance formula. The study also discovered that the Forrest Gump movie adheres to Janice Radway's ideal romance formula while adapting it to the disability setting. The individuals' personalities are given more depth by this extra complexity, which also advances the story as a whole. The Forrest Gump movie accurately, tenderly, and meaningfully shows romantic connections between individuals with impairments, according to the study. Forrest's intellectual impairment isn't the main focus of his persona; rather, it's only one facet of who he is. The movie demonstrates that Forrest is a loving, kind, and sympathetic individual who is able to develop lasting connections despite his impairment. Jenny's reaction to Forrest's impairment is honestly portrayed in the movie, and she first has second thoughts about dating him. She comes to see, nevertheless, that Forrest's impairment is only one aspect of him and does not characterize him as a person as their relationship progresses.
Content of selected polyphenolic substances in parts of grapevine
Authors: Jurasova Lenka , Jurikova Tunde , Baron Mojmir , Sochor Jiri
Published: July 2023

This review provides an overview of the variety of occurrences, content, extraction and health effects of selected polyphenolic compounds associated with different parts of grapevine (seeds, peel, pulp and stems). The review provides a brief characterisation of grape parts, the content of polyphenolic compounds and their extraction together with their graphical forms of presentation and diversity as determined by different studies. The content of individual polyphenolic compounds differed with studies. Effects of different factors were evident in both growing style and geographical location of vineyards as well as extraction methods and analytical conditions.
The use of communicative activities for developing speaking skills of students at english lessons
Authors: Shevelova-Harkusha Natalia
Published: July 2023

This article is devoted to the issue of the use of communicative activities for the development of speaking skills of students in the university. It was established, that the intensification of the educational process requires the search and use of new forms, methods and technologies of teaching and learning, means of supporting students' interest in the material and activation of their cognitive activity. Thus, one of the urgent problems of modern methods of teaching foreign languages ​​is the organization of the teaching process for students of different age groups with the help of a communicative approach. The article mentions various types and subtypes of conditionally communicative and fully communicative activities, which are most commonly used to teach students speaking foreign language. The article also defines the features and the means of using certain types of speech activities, in particular, reproductive exercises, which include: 1) retelling, 2) abbreviated and selective retelling, 3) retelling-translation, 4) dramatization, 5) creative retelling. As for responsive activities, they include: 1) question-and-answer exercises, 2) replica exercises, 3) free conversation. Among the productive activities, we highlight the following: situational activities that combine 1) solving problem situations, 2) imaginary situations, 3) role-playing. Descriptive activities include various types of descriptions. The article also talks about the advantages of discussion activities, mainly 1) educational discussion, 2) commenting, 3) situational discussions, as well as compositional activities and press conferences. The article states that during the performance of communicative activities, the work should be aimed at involving students into communicatively oriented activities regarding the observation of the phenomena being studied, at revealing the connections and relationships between the means of expressing information, at finding language units for expressing one's own opinion, etc. It was established, that it is also necessary to develop communicative exercises and activities based on real-life material or a model text, which are relevant for students of a certain age, which are interesting, close and understandable for students, which have educational and socio-cultural potential
Solidão e sua associação com indicadores sociodemográficos e de saúde em adultos e idosos brasileiros: ELSI-Brasil
Authors: Sandy Júnior Paulo Afonso , Borim Flávia Silva Arbex , Neri Anita Liberalesso
Published: July 2023

Resumo: O objetivo foi investigar a prevalência de solidão e suas associações com indicadores sociodemográficos e de saúde em amostra nacionalmente representativa de adultos e idosos brasileiros. Foram analisados dados da linha de base (2015-2016) do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil) e incluídos os participantes com informações completas nas variáveis de interesse (n = 7.957). Solidão foi a variável de desfecho, cuja medida baseou-se na pergunta “Com que frequência o(a) senhor(a) se sentiu sozinho(a) ou solitário(a): sempre, algumas vezes ou nunca?”. As variáveis independentes compreenderam indicadores sociodemográficos e comportamentos e condições de saúde. As análises incluíram o teste qui-quadrado de Pearson, para cálculo das frequências relativas, e a regressão de Poisson, para estimativa das razões de prevalência (RP) e respectivos intervalos de 95% de confiança (IC95%). A prevalência de sempre sentir solidão foi de 16,8%; de algumas vezes, 31,7%; e de nunca, 51,5%. Foram observadas associações significativas entre sempre sentir solidão e depressão (RP = 4,49; IC95%: 3,93-5,11), morar só (RP = 2,44; IC95%: 2,12-2,82), baixa escolaridade (RP = 1,93; IC95%: 1,61-2,32), sexo feminino (RP = 1,53; IC95%: 1,36-1,72), autoavaliação de saúde ruim/muito ruim (RP = 1,48; IC95%: 1,27-1,73) e qualidade do sono ruim/muito ruim (RP = 1,21; IC95%: 1,05-1,41). Dado seu potencial de prejuízo à qualidade de vida, é necessário conhecer longitudinalmente as trajetórias da solidão e as variáveis associadas e usar esse conhecimento para o delineamento de políticas públicas e intervenções em saúde que poderão beneficiar o bem-estar biopsicossocial de adultos e idosos brasileiros.
Risk of depression during pregnancy in usual risk antenatal care
Authors: Silva Mônica Maria de Jesus , Serrano Tainah Barbosa de Moraes , Porcel Giovanna da Silva , Monteiro Bruna Borlina , Clapis Maria José
Published: July 2023

Objective: to identify the risk of depression during pregnancy among pregnant women receiving routine prenatal care and the associated factors. Method: a cross-sectional study, carried out with 201 pregnant women, in a routine prenatal clinic of a university maternity hospital. Data were collected using an electronic form containing a characterization instrument and the Escala de Risco de Depressão na Gravidez (Depression during Pregnancy Scale). The dependent variable was the risk of depression during pregnancy. Statistical analysis was performed by calculating the Odds Ratio and using the Chi-square and Fischer’s Exact tests. Results: among the participants, 68.2% had a higher risk of depression during pregnancy. There was a statistically significant association between a higher risk of depression during pregnancy and occupation (p=0.04), that is, unemployment (OR=2.00) doubled the risk of depression. Conclusion: the high prevalence of the risk of depression during pregnancy indicates the necessity of planning, prioritizing, and integrating mental health into prenatal health services, especially in the primary healthcare environment, by health managers and policymakers.
Risco de depressão na gravidez na assistência pré-natal de risco habitual
Authors: Silva Mônica Maria de Jesus , Serrano Tainah Barbosa de Moraes , Porcel Giovanna da Silva , Monteiro Bruna Borlina , Clapis Maria José
Published: July 2023

Objetivo: identificar o risco de depressão na gravidez entre gestantes inseridas na assistência pré-natal de risco habitual e os fatores associados. Método: estudo transversal, realizado com 201 gestantes, no ambulatório de pré-natal de risco habitual de uma maternidade universitária. A coleta de dados utilizou um formulário eletrônico contendo um instrumento de caracterização e a Escala de Risco de Depressão na Gravidez. A variável dependente foi o risco de depressão na gravidez. A análise estatística deu-se pelo cálculo da razão de chances (Odds Ratio) e pelos testes Qui-quadrado e Exato de Fischer. Resultados: entre as participantes, 68,2% apresentaram maior risco de depressão na gravidez. Houve associação estatisticamente significativa entre o maior risco de depressão na gravidez e a variável ocupação (p=0,04), ou seja, a ausência de emprego (OR = 2,00) aumentou em duas vezes a chance de ocorrência. Conclusão: a alta prevalência de risco de depressão na gravidez evidencia a necessidade de planejamento, priorização e integração da saúde mental nos serviços de saúde pré-natal, principalmente no ambiente da Atenção Primária à Saúde, por parte de gestores de saúde e formuladores de políticas.
Elaboración e implementación de un protocolo para la Hora Dorada de recién nacidos prematuros utilizando ciencia de la implementación
Authors: Silva Elizangela Sant’Anna da , Primo Cândida Caniçali , Gimbel Sarah , Almeida Márcia Valéria de Souza , Oliveira Norma Suely , Lima Eliane de Fátima Almeida
Published: July 2023

Objetivo: describir el proceso de diseño e implementación de un protocolo de atención para la primera hora de vida del recién nacido prematuro. Método: investigación participativa, que utilizó el marco de la ciencia de la implementación y los dominios del Consolidated Framework for Implementation Research. Estudio realizado en un hospital escuela del sureste de Brasil, con la participación del equipo multidisciplinario y de los gestores. El estudio se organizó en seis etapas, mediante del ciclo de mejora continua (Plan, Do, Check, Act): diagnóstico situacional; elaboración del protocolo; capacitaciones; implementación del protocolo; relevamiento de barreras y facilitadores; seguimiento y revisión del protocolo. Los datos fueron analizados mediante estadística descriptiva y análisis de contenido. Resultados: el primer protocolo de la Hora Dorada de la institución fue organizado por el equipo multidisciplinario a partir de un enfoque colectivo y dialógico. El protocolo priorizó la estabilidad cardiorrespiratoria, la prevención de hipotermia, hipoglucemia e infección. Después de cuatro meses de capacitación e implementación, el protocolo fue evaluado como una intervención de calidad, necesaria para el servicio, de bajo costo y de poca complejidad. La principal sugerencia de mejora fue realizar actividades educativas frecuentes. Conclusión: la implementación generó cambios e inició un proceso de mejora de la calidad de la atención neonatal, es necesario que la capacitación sea continua para lograr mayor adherencia y mejores resultados.
Use of convalescent plasma to treat COVID-19: case studies
Authors: Beneti Stéphani Caroline , Marques Leila Larisa Medeiros , Mattos Gisely , Cardoso Flávia Aparecida Reitz
Published: July 2023

Abstract There have been several efforts to minimize the effects caused by the COVID-19 virus around the world. Vaccines were developed in record time and alternative therapies were studied and applied in several countries, such as the use of plasma from recovered patients. Identifying, systematically evaluating and summarizing the best available scientific evidence on the efficacy and safety of using plasma from recovered COVID-19 patients remains the objective of this study. The studies carried out showed that the application of convalescent plasma contributes to the reduction of mortality, viral load and length of hospital stay. However, the effectiveness of the therapy still raises doubts due to the number of patients evaluated in clinical studies, in addition to its high cost and limitations in terms of availability and implementation, with the drug being authorized only for hospital use.
Effectiveness of Official Counseling Practices To Understanding Efforts Of The First 1000 Days Of Life Prospective Brides In The Working Area Of Religious Affairs Office, Bengkulu City: Qualitative Study
Authors: Wahyudi Anang , Mujayanto
Published: July 2023

Reducing the prevalence of stunting in children needs to involve cross-sectors, one of which is the KUA (Office of Religious Affairs) which has officers who give lectures related to religion. The model for health counselors, especially nutrition, is the empowerment of religious officers in the Office of Religious Affairs who will provide materials to the prospective bride and groom, after the religious officers of the prospective bride and groom receive provision of knowledge on nutritional health, which in this case is the first 1000 days of life to prevent stunting. The purpose of the KUA health counselor is to change the behavior of the prospective bride and groom towards healthy behavior. The working mechanism of this health counselor model is (1) the religious officers of the prospective bride and groom receive health knowledge, especially nutrition, provided by members of the community service, (2) these counselor officers convey their knowledge to the prospective bride and groom in the form of messages accompanied by service members public. The purpose of this study is to analyze the effectiveness of Officer Counseling practices on Understanding Efforts of 1000 HPK Candidate Brides in the Work Area of the Office of Religious Affairs in the City of Bengkulu and how the factors influence it. Qualitative descriptive research method with a focus group discussion approach.
Modification of The Headman Role on Increasing Knowledge and Attitudes About Breastfeeding and Complementary Food in A Remote Island
Authors: Yorita Epti , Dahrizal  , Sahidan  , Gustina Mely , Yulinda
Published: July 2023

One of the health program's priorities is to reduce the incidence of stunting. Interventions currently being carried out focus on the first 1000 days of life. However, they have not been successful due to difficult access, educational, socio-economic and cultural factors, such as on the remote island of Enggano. Therefore, cultural-based intervention is needed with local communities as the perpetrators because it is the social capital of development. This study aims to determine the influence of the role of the traditional Paabuki leader and cadres on knowledge and attitudes about breastfeeding and complementary food in children under two years old on Enggano Island, North Bengkulu Regency, in 2021.This research uses a quasi-experimental research design without a control group. The intervention was in the form of modifying the role of traditional Paabuki leaders and cadres in training. Samples were 40 women with children under two years old selected by purposive sampling. The research results on the role of Paabuki and cadres affected knowledge and attitudes about breastfeeding and complementary food with a p-value = 0.00. However, they did not affect breastfeeding behavior and complementary food with a p-value =1. Parity is the most influential factor in knowledge and attitudes about breastfeeding and complementary feeding (p-value =0.01). The role of Paabuki and cadres can be modified as channel media in providing information and advocacy about breastfeeding and complementary food. Service providers must carry out program innovations based on local culture so that the community more easily accepts them.
Household Characteristics and Nutritional Status of Children to Children in Coastal Family in Bengkulu Province
Authors: Yuliantini Emy , Sukiyono Ketut , Sulistyo Bambang , Yuliarso M. Zulkarnain
Published: July 2023

Coastal areas have a lot of natural wealth potential. The poor nutritional status of children under five in fishing families is greater than in farming families. Family characteristics such as education, knowledge, work and family income are the most important parts in ensuring family food security, so it is necessary to know the characteristics and nutritional status of children under five in coastal families in Bengkulu province. The research method is descriptive analytic with a cross-sectional approach. The sample in this study were mothers who had children under five in the locus and not loci stunting on the coast of Bengkulu province totaling 479.  The result of the research is that most of the characteristics of children under five are < 3 years old. Gender is mostly female. Mother's Characteristics Factors are mostly <35 years old, while most of them have high education. Almost all mothers of toddlers do not work. Meanwhile, the majority of family incomes are still below the minimum wage. Of the three indicators of BB/U, TB/U, and BB/TB Bengkulu coastal families have public health problems. The food security factor of food diversity is mostly food security, the analysis of the quantity of food in the medium category and the analysis of the highest food quality are utilized. It is hoped that the characteristics and risk factors for the occurrence of community nutritional problems in children under five in coastal areas are a concern and need further researchers with different research methods.
Relationship between Dietary Acid Load with Kidney Function among Chronic Kidney Disease Patients
Authors: Rusdi Faza Yasira , Dewi Mira , Dwiriani Cesilia Meti
Published: July 2023

Chronic kidney disease (CKD) affects the structure and function of the kidneys. The burden of disease from CKD is expected to increase as the prevalence of CKD increases from year to year. The quality of the diet plays a role in the management and treatment of CKD. The diet quality of CKD patients is assessed using dietary acid load (DAL) which is estimated based on protein and potassium intake. A high score of DAL can lead to more rapid decline in renal function, rapid decline in GFR, and low-grade subclinical acidosis. This study was aimed to analyze the relationship between dietary acid load and kidney function in CKD patients with hemodialysis at the Bogor City Hospital. This study used a cross sectional design involving 50 subjects with CKD on hemodialysis. Data was collected by interview using a questionnaire for data characteristics and Semi Quantitative Food Frequency Questionnaire (SQ-FFQ) for data intake. There was a significant relationship between DAL and eGFR, urea, and creatinine (p<0,05). The level of DAL plays an important role in the development and severity of CKD. Therefore, dietary recommendations for patients CKD on hemodialysis need to focus to the dietary acid load derived from foods and to the condition of hyperkalemia. Further research is expected to be carried out with an intervention, case control or cohort design, as well as using different equations in estimating DAL such as the net acid excretion (NAE), potential renal acid load (PRAL) equation.
Protein Quality of Ready to Use Therapeutic Food (RUTF) Bar Product for Children Under Five Years with Severe Acute Malnutrition
Authors: Novia Reni , Setiawan Budi , Marliyati Sri Anna
Published: July 2023

Produk RUTF (Ready to Use Therapeutic Food) merupakan salah satu produk alternatif yang disarankan oleh WHO dan UNICEF untuk diberikan kepada balita yang mengalami malnutrisi akut berat. Pada pengembangan produk RUTF perlu dipertimbangkan daya terima, kualitas gizi termasuk termasuk kualitas protein dari produk yang dihasilkan. Penelitian ini bertujuan untuk menganalisis kualitas protein produk Ready to Use Therapeutic Food (RUTF) bar untuk balita malnutrisi akut berat. Penelitian ini menggunakan studi eksperimen dengan 2 kali ulangan dan duplo. Analisis yang dilakukan meliputi profil asam amino, daya cerna protein dan perhitungan estimasi nilai PDCAAS (Protein digestibility Corrected Amino Acid Score).  PDCAAS merupakan salah satu metode penilaian kualitas protein dalam suatu produk pangan yang dapat dilakukan dengan membandingkan asam amino yang terdapat pada makanan dengan asam amino kebutuhan standar lalu dikalikan dengan daya cerna protein. Hasil analisis profil asam amino menunjukkan skor asam amino pembatas dan estimasi nilai PDCAAS produk masih cukup rendah yaitu masing-masing sebesar 36% dan 34.2%. Hasil ini masih belum memenuhi standar produk RUTF yang dianjurkan oleh WHO dan FAO. Hasil analisis daya cerna protein produk RUTF berbentuk bar tergolong tinggi yaitu sebesar 94.9 ± 0.2 % dan sudah memenuhi standar produk RUTF yang dianjurkan. Perlu penambahan jumlah serealia atau pangan hewani atau whey protein concentrate atau pengolahan pangan menggunakan metode ekstrusi agar kualitas protein produk RUTF bar untuk balita malnutrisi akut berat semakin baik dan memenuhi standar produk RUTF yang direkomendasikan.
Unveiling the Remarkable Antioxidant Activity of Plant-Based Fish and Seafood Analogs through Electrochemical Sensor Analysis
Authors: Magarelli Gabriella , Bonatto Cínthia Caetano , Da Rocha Vaz Gabriela Mendes , Lauria Victoria Baggi Mendonça , Silva Luciano Paulino
Published: July 2023

The global consumption of vegan foods is experiencing an expressive upward trend, underscoring the critical need for quality control measures based on nutritional and functional considerations. This study aimed to evaluate the functional quality of caviar and salmon analogs food inks, based on pulses combined with nano ingredients. The primary objective of this work was to determine the total antioxidant compounds contained in these samples using a voltammetric technique with a glassy carbon electrode. Approximately 100 mg of samples underwent ethanolic extraction (70%) with 1 hour of stirring. The voltammograms were acquired under specific conditions: 10 mL of phosphate buffer electrolyte with a pH of 3.0; an initial potential (Ei) of 0.0 V; a final potential (Ef) of 1.0 V; a pulse amplitude of 50 mV; and a scan rate of 50 mV s-1. The reference electrode used was Ag/AgCl (KCl 3 mol L-1), and the auxiliary electrode was a platinum wire. The voltammograms revealed prominent anodic current peaks at 0.76-0.78 V, which are attributed to isoflavones. Isoflavones, known secondary metabolites with substantial antioxidant potential commonly found in pulses, were identified. The total isoflavone concentrations obtained ranged from 31.5 to 64.3 mg Eq genistein 100 g-1. The results not only validated the efficacy of the electrochemical sensor for quantifying total antioxidant compounds in the samples but also demonstrated that the concentration of total isoflavones in caviar and salmon analogs fell within the expected limits.
Differential effects of environmental conditions on the commercially important attributes and postharvest quality of pomegranate fruit
Authors: Zarei Abdolkarim , Khademi Orang , Erfani-Moghadam Javad
Published: July 2023

To investigate the effects of varying climate conditions on the commercial production and shelf life of pomegranate, the main qualitative characteristics of fruit were compared in two pomegranate varieties in their traditional habitats and a new location. Our results revealed that most fruit traits were influenced by growing zones. Specifically, the content of anthocyanin, red color (a*) in aril and fruit peel, as well as titratable acidity in both varieties were significantly decreased in the new, warmer habitat, while, the antioxidant content experienced a more moderate reduction in the new place. On the other hand, the fruits grown in the new climate had substantially higher maturity index and hardness, as well as L* and b* pigments. However, the two varieties responded differently to traits such as 100 arils fresh weight and total soluble solids. The mineral content of fruit was also affected by growing locations, specifically the Ca level of fruits experienced a significant increment in the new climate. The new habitat improved the postharvest quality of fruits, and substantially lower electrolyte leakage and chilling damages were detected in warmer conditions. Taken together the fruits produced from the warmer region were superior to those obtained in their moderate traditional habitats owing to their long-term cold storage, taste index, and nutrients. These results enhance our knowledge regarding the expression of fruit traits in connection with the environment and can be beneficial for making sound planting decisions and crop improvement programs with the aim of improving the quality and postharvest life of fruit.
Optimizing Cone-Beam Computed Tomography (CBCT) exposures for effective radiation dose and image quality balance
Authors: Santos Ananda Amaral , Silva Brunno Santos Freitas , Correia Fernanda Ferreira Nunes , Silva Maria Alves Garcia , Freitas Deborah Queiroz , Yamamoto-Silva Fernanda Paula
Published: July 2023

Objectives This study aimed to evaluate the influence of different CBCT acquisition protocols on reducing effective radiation dose while maintaining image quality. Materials and Methods The effective dose emitted by a CBCT Picasso Trio® device was calculated using thermoluminescent dosimeters (TLDs) placed in a Rando Alderson phantom, following the ICRP 103 (2007) guidelines. Image quality was assessed by three experienced evaluators, who examined CBCT images for anatomical structure identification and image quality impressions. The relationship between image quality and confidence was evaluated using Fisher's Exact Test, and the agreement among raters was assessed using the Kappa test. Multiple linear regression analysis was performed to investigate whether the technical parameters could predict the effective dose. Results The optimized protocol with 3 mA, 99 kVp, and 450 projection images demonstrated good image quality and a lower effective dose for radiation-sensitive organs. Image quality and confidence had consistent values for all structures (p < .05). The multiple linear regression analysis resulted in a statistically significant model. The mA (b = 0.504; t = 3.406; p = 0.027), kVp (b = 0.589; t = 3.979; p = 0.016), and projection images (b = 0.557; t = 3.762; p = 0.020) were predictors of the effective dose. Conclusions Optimized CBCT acquisition protocols can significantly reduce effective radiation dose while maintaining acceptable image quality by adjusting the mA, projection images, and kVp. Clinical Relevance: These findings can contribute to the optimization of CBCT imaging protocols, allowing clinicians to obtain high-quality images with reduced radiation exposure.
Lithostratigraphy of the southeastern part of the Ethiopian flood basalt province
Authors: Getaw Andualem , Ayalew Dereje , Fontijn Karen
Published: July 2023

Fully preserved continental flood basalt stratigraphy provides a perfect window to comprehend the temporal evolution and geological history of plume-related volcanism, since continental flood basalt does not represent a primary magma, detail stratigraphic and phase equilibrium studies offer insight into the fractionation processes and plumbing system of the volcanism that leads to continental flood basalts. This study presents a new flow-by-flow petrographic modal description, major element and stratigraphic framework of Cenozoic rocks from the central part of the southeastern Ethiopian flood basalt province (the Chole section). Based on the petrographic variation and volcanic hiatus marker the section is divided in to: 1) lower flood basalt, 2) middle flood basalt and 3) upper flood basalt. The lower flood basalt is a transitional basalt with quartz-hypersthene and olivine-hypersthene normative alternate with narrow range of MgO (4.8-5.66 wt.%) and SiO2 (47.06-48.88 wt.%). The middle flood basalt is silica undersaturated basalt and plots towards the primitive magma composition with MgO (6.4-12.6 wt.%), whereas the upper flood basalt is quartz-hypersthene normative sub-alkaline tholeiitic basalt with SiO2 (49.73-53.73 wt.%) and MgO (4.16-6.49 wt.%). The Phase assemblage and major element demonstrate that the lower flood basalt in the province experienced low-pressure fractionation involving olivine + plagioclase + clinopyroxene with variable degree of recharge. A transition in modal mineralogy from plagioclase aphyric-phyric lower flood basalt to plagioclase-free olivine-pyroxene phyric middle flood basalt suggests a change in the magma plumbing system. Changes in modal mineralogy, decreasing flow thickness, and periodic eruption in the middle flood basalt are interpreted as the result of a significant decrease in magma production and magmatic flux to the lower and upper stalled magma reservoir. The lower stalled reservoir directly fed the middle flood basalt. The plagioclase aphyric-microcrystalline upper flood basalt results from low-pressure fractionation of olivine + plagioclase + clinopyroxene, and the basalt uncomformably overlies the middle flood basalt, implying changes in the parent magma and plumbing system.
The Role of Hypoxia-inducible Factor-1 in Bladder Cancer
Authors: Chai Jiagui , Yin Sifan , Feng Wenbo , Zhang Tao , Ke Changxing
Published: July 2023

Bladder cancer (BC) is one of the most common malignant tumors worldwide
and poses a significant hazard to human health. During the development of BC, hypoxia
plays a crucial role. Hypoxia-inducible factor (HIF) is a key transcription factor for
hypoxic adaptation, which regulates the transcription of various genes, including
inflammation, angiogenesis, and glycolytic metabolism. Recent studies have shown the
precise role of HIF in various biological behaviors of BC. More importantly, a new
antitumor medication targeting HIF-2 has been used to treat renal cancer. However,
therapies targeting HIF-1 in BC have not yet been developed. In this review, we
discussed how HIF-1 is expressed and affects the growth, metastasis, and angiogenesis
of BC. At the same time, we investigated several HIF-1 inhibitors that provide new
perspectives for targeting HIF-1.
Peer Review of “The Loch Ness Monster: If It’s Real, Could It Be an Eel?” (Preprint)
Authors: Jellyman Don
Published: July 2023

UNSTRUCTURED
Analisis Hubungan Sosial antara Komite Audit dan Kantor Akuntan Publik (KAP) terhadap Kualitas Audit
Authors: Arif Viny Amelia , Cheisiviyanny Charoline
Published: July 2023

This study aims to determine the social relationship between the audit committee and the public accounting firm (KAP) on the audit quality of state-owned companies listed on the Indonesian stock exchange with embeddedness theory. The population of this study is all financial statements of state-owned companies listed on the Indonesia Stock Exchange in the 2016-2019 period with a sample of 60 financial statements using purposive sampling technique, namely considerations. Data analysis used descriptive statistical test and measurement model (Outer Model). The results of data analysis with Adjusted R-squared or simultaneous test show a value of 0.111 or 11.1% which means that social relations affect audit quality by 11.1% which can be categorized as quite low and the remaining 88.9% is influenced by other variables. others outside of this study. This means that social relations have a positive effect on audit quality in state-owned companies listed on the Indonesian stock exchange in the 2016-2019 period.
Determinan Praktik Internet Financual Reporting (IFR) pada Website Pemerintah Daerah Sumatera Barat
Authors: Budiman Alkausar Putra , Agustin Henri
Published: July 2023

This study aims to find out the factors that influence internet financial reporting (IFR) on local government websites. In this study, 19 regencies and cities in West Sumatra were used. The data used is from 2015 to 2019. The data analysis method used to prove the correctness of the hypothesis is multiple regression which is processed using SPSS. Based on the results of hypothesis testing, it was found that the type of local government and the characteristics of local government had a negative effect on the amount of internet financial reporting disclosure in 19 regencies and cities in West Sumatra, while the age of the local government had no significant effect on the amount of internet financial reporting disclosure in 19 regencies and cities in West Sumatra.
Pengaruh Ukuran Dewan Direksi dan Islamic Corporate Social Responsibility terhadap Nilai Perusahaan: Studi pada Bank Syariah yang Terdaftar di OJK Tahun 2016-2020
Authors: Ramadhani Wulandary , Serly Vanica
Published: July 2023

The purpose of this study was to determine the effect of board size and Islamic corporate governance on firm value. The population in this study are Islamic Commercial Banks registered with the OJK. The research design in this study is a quantitative approach using secondary data. Secondary data is obtained from each website of Islamic Commercial Banks. We then analyzed the data using multiple linear regression analysis techniques. This research is (1) board size has a significant effect on firm value (2) Islamic corporate social responsibility has no effect on firm value.
Examination of the haematological profile of pregnant Polish Holstein-Friesian black-and-white cattle in the early stage
Authors: Wrzecińska Marcjanna , Kowalczyk Alicja , Czerniawska-Piątkowska Ewa , Kordan Władysław , Araujo Jose Pedro
Published: July 2023

Introduction

Cattle health and welfare are monitored via the analysis of the haematological profile, and it shows cattle’s ability to adapt to changing environmental conditions, pregnancy and lactation; profile changes also indicate reproductive disorders. The literature lacks reports of the examination of the haematological profile in cows up to the 50th day of pregnancy (dop). Therefore, this research examined that in cows up to this pregnancy stage.

Material and Methods

A total of 101 Polish Holstein-Friesian black-and-white cows were divided into groups. The control groups consisted of non-pregnant heifers (group C00) and non-pregnant cows (group C0), and the experimental groups were pregnant heifers (group T1 at dop ≤ 28 and group T2 at dop ≥ 29–dop < 45) and pregnant cows (group T3 at dop ≥ 29–dop ≤ 50). In addition, the T3 group was divided into cows pregnant for up 45 dop and cows between 45 and 50 dop. Blood samples were collected in March and April 2021 from each animal and analysed. A transrectal ultrasound examination was performed to detect and confirm pregnancy.

Results

Statistically significant differences (P ≤ 0.01) between the group of cows at dop < 45 dop and those at dop ≥ 45–dop ≤ 50 dop were noted in granulocyte percentage (GRA%), white and red blood cell counts (WBC/RBC), platelets (PLT), platelet distribution width (PDW), haematocrit (HCT) and lymphocyte percentage (LYM%). No statistically significant differences were found in the mean corpuscular haemoglobin, monocytes (MON), monocyte percentage (MON%), mean platelet volume (MPV), thrombocrit or red blood cell distribution width (RDW). Similar statistically significant differences (P ≤ 0.01) emerged between the groups of heifers in PLT, GRA, RBC, lymphocytes, LYM% and HCT, and no significant differences were found between MPV, MON, MON% or RDW.

Conclusion

Examining the haematological profile in high-yielding cattle is vital in maintaining herd profitability and high reproduction, which depend on the quick diagnosis of disorders facilitated by haematology. This study analysed the haematology profile of dairy cattle at dop ≤ 50 for the first time, indicating changes in lymphocyte levels, which suggests that the animals experienced direct stress during the study.
Energy Management Strategy Considering Energy Storage System Degradation for Hydrogen Fuel Cell Ship
Authors: Cao Wei , Geng Pan , Xu Xiaoyan , Tarasiuk Tomasz
Published: July 2023

A hybrid energy system (HES) including hydrogen fuel cell systems (FCS) and a lithium-ion (Li-ion) battery energy storage system (ESS) is established for hydrogen fuel cell ships to follow fast load transients. An energy management strategy (EMS) with hierarchical control is presented to achieve proper distribution of load power and enhance system stability. In the high-control loop, a power distribution mechanism based on a particle swarm optimization algorithm (PSO) with an equivalent consumption minimization strategy (ECMS) is proposed. In the low-level control loop, an adaptive fuzzy PID controller is developed, which can quickly restore the system to a stable state by adjusting the PID parameters in real time. Compared with the rule-based EMS, hydrogen consumption is reduced by 5.319%, and the stability of the power system is significantly improved. In addition, the ESS degradation model is developed to assess its state of health (SOH). The ESS capacity loss is reduced by 2% and the daily operating cost of the ship is reduced by 1.7% compared with the PSO-ECMS without considering the ESS degradation.