bluuebunny/crossref_metadata_2025 huggingface dataset:
Photosynthesis parameters and productivity of crambe abyssinica when using growth regulators
Authors: Prakhova T. Ya. , Odrin I. V.
Published: August 2024

The article presents an assessment of the formation of photosynthetic activity of crambe abyssinica and its productivity depending on foliar feeding with growth regulators to optimize the elements of its cultivation technology in the forest-steppe conditions of the Middle Volga region. Experimental work was carried out in 2021–2023. The object of research was the crambe abyssinica variety Demetra. The experimental design included the following options: control (without treatment); Blackjack (1.0 l/ha); Humate K/Na (1.0 l/ha); Zircon (1.0 l/ha); Albit (0.5 l/ha). The study conditions were different, the GTC varied from 0.80 to 1.29. Foliar treatment with preparations was carried out at the beginning of the budding phase of the crop. The use of growth regulators had a positive effect on the photosynthetic activity of crambe crops. Their use contributed to an increase in the assimilation surface area by 6.2…8.9 thousand m2/ha, photosynthetic potential by 0.3…0.5 thousand m2 × day/ha, net photosynthetic productivity by 0.3…1, 5 g/m2 × day and leaf surface index by 0.17…0.35 compared with the control. The largest area of leaves was formed during the flowering phase of crambe and was noted in variants with foliar treatment with the regulators Blackjack and Humate K/Na (69.1 and 70.3 thousand m2/ha). The maximum value of photosynthetic potential was noted in the variant with the use of Humate K/Na (3.40 million m2/ha × day). The highest indicator of net photosynthetic productivity (4.95 g/m2 × day) was observed in the variant treated with Zircon. The greatest increase in this parameter was observed against the background of the Zircon and Blackjack regulators, which amounted to 2.44. The coefficient of PAR use by crambe plants was 1.28…1.78 % depending on the treatment used, with 1.16 % in the control variant. The average crambe yield for 2021–2023 was 1.69…1.98 t/ha. The use of growth regulators contributed to a significant increase in yield, the increase was 0.21…0.29 t/ha. The most effective were the Zircon and Blackjack regulators, the use of which ensured the formation of the highest seed yield – 1.98 and 1.94 t/ha, respectively.
Species composition of septoria blotch of cereal crops and identification of effector genes in populations of Parastagonospora spp. on the territory of Krasnodar and Leningrad regions of the Russian Federation
Authors: Zeleneva Yu. V. , Ablova I. B. , Mokhova L. M.
Published: August 2024

The studies were conducted in Krasnodar and Leningrad Oblast s in order to clarify the species composition of wheat septoriosis pathogens and further characterize the populations of Parastagonospora nodorum and P. pseudonodorum for the presence of effector genes Tox1, Tox3, ToxA and Tox267 using associated molecular markers to create artificial infection backgrounds to identify sources and donors of leaf spot resistance. The material for the study was represented by samples of affected plants collected in 2023. In the Leningrad Oblast and Krasnodar Krai the species of Zymoseptoria tritici demonstrated predominance. It was detected on all of the examined plant samples (100 % occurrence). P. nodorum and P. pseudonodorum were noticed less frequently in the Leningrad Oblast, the occurrence of P. nodorum was 80 %, while P. pseudonodorum – 60 %. In Krasnodar Krai, the occurrence of P. pseudonodorum comprised 35.29 %, while P. nodorum – 11.76 %. In the present study the primer pair SnTox2DONRF/SnTox2DONRS was applied for the first time to test Russian populations of Parastagonospora spp. for the presence of the Tox267 gene. Molecular screening revealed the ToxA and Tox1 genes in P. nodorum and P. pseudonodorum, while the Tox3 and Tox267 genes were identified only in P. nodorum. Of the 28 P. nodorum isolates studied, the presence of the ToxA gene was found in 29 % (8 isolates from the Krasnodar Krai). The Tox1 gene was noted in 32 % (5 isolates from the Leningrad Oblast and 4 from the Krasnodar Krai). The Tox3 gene was identified in 64 % of 28 (8 isolates from the Krasnodar Krai and 10 from the Leningrad Oblast). The Tox276 gene was found only in the genotype of 8 isolates from the Krasnodar Krai, which amounted to 29 % of those studied. The study also included 87 isolates of P. pseudonodorum. Of these, 5 % had ToxA in the genotype (4 isolates from the Krasnodar Krai) and 23 % Tox1 (17 isolates from Leningrad Oblast; 3 from the Krasnodar Krai).
Fractional composition of copper compounds in metal–contaminated soil and its accumulation in plants in application of growth promoting rhizosphere bacteria
Authors: Shabayev V. P. , Volokitin M. P. , Ostroumov V. E.
Published: August 2024

Studies were carried out to investigate effect of application of growth-promoting rhizosphere bacteria of genus Pseudomonas in artificial contamination of agro-gray soil with copper in concentration above approximately permissible level on fractional composition of metal compounds in soil, weight of spring wheat plants and metal uptake by plants in pot experiment. To assess effect of bacteria on distribution of copper in soil fractions, inoculation with cultures P. fluorescens 20, P. fluorescens 21, and P. putida 23 was used. Wheat plants were grown up to booting stage in contamination with Cu(NO3)2·3H20 at rate of 300 mg Cu/kg of soil against background of NPK fertilization. Cu accumulation in fractions associated with organic matter, oxides and hydroxides of Fe and Mn and, to a lesser extent, with carbonates was established. Content of Cu in shoots and roots after combustion in mixture of HNO3 : HClO4 (2:1) and in soil fraction was determined by inductively coupled plasma emission-optical spectrometry. Bacteria rised plant resistance to high copper concentration and increased their weight by 13…24 %, reducing the phytotoxicity of metal. Positive effect of bacteria in copper contamination is due to increase in content of metal in roots (in 18…19 times relative to variant with copper contamination without bacteria application). Bacteria increased copper content mainly in specifically sorbed fraction associated with carbonates and in composition of ferruginous minerals, to lesser extent in organic fraction and decreased content of metal in residual fraction. Growth in copper uptake by plants from the soil by 19…30 % in application of bacteria corresponded to increase in its presence in soil in relatively mobile forms and decrease in the residual fraction.
The influence of moisture content on extrusion modes and physicochemical parameters of extrudates with the addition of chokeberry pomace hydrolysate
Authors: Sharikov A. Yu. , Ivanov V. V. , Amelyakina M. V. , Sokolova E. N. , Ionov V. V. , Serba М. М.
Published: August 2024

The influence of the moisture content during the extrusion of a mixture of rice with chokeberry pomace hydrolysate on the process parameters, physico-chemical, structural, textural and technological properties of the extrudates was studied. The relevance of the study is due to the need to increase the sustainability of technological processing of fruit and berry raw materials and increase the efficiency of using by-products of food industry. Hydrolysate of chokeberry pomace was obtained using a complex of enzymes, including pectinase, cellulase, protease and lipase. The hydrolyzate was dried, added to rice in an amount of 5 % and extruded at various moisture content in the range of 15…24 %. An increase in moisture content during extrusion reduced the process temperature from 165 to 148 ℃, the pressure from 5.0 to 2.0 MPa and the torgue from 88 to 48 %. A decrease in moisture reduced the intensity of the impact of the treated mixtures on biopolymers. The specific mechanical energy decreased from 0.17 to 0.09 kW hour/kg. The trends in changes in thermomechanical treatment modes, determined by moisture as a factor reducing friction, were identical for the control and experimental mixtures without significant differences. With an increase in moisture content during extrusion, the hardness of samples containing berry pomace hydrolysate increased from 11.1 to 43.5 N, bulk density from 97.0 to 278.8 g/dm3, and the sectional expansion index decreased from 8.5 to 3.0. The dynamic viscosity of suspensions of ground extrudates under hydration conditions simulating instant steeping in domestic conditions increased significantly from 2.0 to 3.4…4.4 Pa s with an increase in moisture content during extrusion. Extrusion increased the content of phenolic substances in samples with chokeberry pomace hydrolysate. The maximum value of 631.5 mg/dm3 corresponded to 15 % moisture content.
Evaluation and analysis of the socio-economic potential of territorial communities
Authors: Uhodnikova Olena , Rudachenko Olha , Troian Vladyslava , Bogdan Nataliia , Kravtsova Sofiia
Published: August 2024

In the face of constant changes in the socio-economic environment, territorial communities encounter various challenges and opportunities. Assessment and analysis of their socio-economic potential become key tools for developing development strategies and ensuring sustainable economic growth. The need for systematic analysis of the socio-economic potential of territorial communities arises from the necessity to identify strengths and weaknesses, opportunities, and threats for effective development management and resolution of socio-economic issues. The purpose of the study is to conduct a comprehensive analysis of the socio-economic potential of territorial communities to identify factors influencing their development and develop recommendations to enhance management efficiency. The object of the study is the socio-economic potential of territorial communities, and the subject is the methods of assessing and analyzing this potential. Special attention is paid to the development of various economic and social spheres at the community level. The study is based on the analysis of domestic and foreign research, statistical data, and geographical analysis. The study identifies key aspects of assessing and analyzing the socio-economic potential of territorial communities, identifies factors influencing their development, and develops recommendations to enhance management and development efficiency. The research results indicate the necessity of systematic monitoring and analysis of the socio-economic potential of territorial communities. Recommendations for implementing the obtained results include improving assessment methods, involving the public in decision-making processes, and developing change management strategies considering the communities' potential.
Learning skills for the future – implementing the 21st-century learning
Authors: Avdiu Eliza , Bekteshi Edita , Gollopeni Besim
Published: August 2024

This research aims to identify essential skills required for 21st-century students, to examine teachers' practices, and to explore the educational classroom content applied for skill development. The research sample consists of ten teachers from five classes in a primary school located in Austria. Employing a qualitative approach, the study is conducted through semistructured interviews with teachers, classroom observations, and analyses of the students´active participation in classes over one month. The results prioritize critical thinking, creativity, and social skills. The emphasis is on internet safety in alignment with curricular requirements, interdisciplinary projects, and self-regulated learning, which are crucial for early education development. Additionally, the data reveals that teachers predominantly utilize open-ended lessons and independent learning activities, while providing flexibility for students to learn independently. Teachers prioritize individual student expression, self-direction, creativity, and imagination in their approach to skill development. They engage in interdisciplinary projects to foster sustainable skill development and promote visual language and literacy to facilitate self-expression and inclusive attitudes. While integral to the learning progress, integrating media and technology poses challenges for children, however, students are adapting to it easily and learn to discern information according to their needs. Challenges identified include maintaining students' focus on tasks, navigating tensions between content mastery and process understanding, and the need for teacher training in pedagogical tools, particularly amid the transition to online teaching. Overall, the study underscores the importance of providing students with opportunities for independent exploration, fostering collaboration, and addressing challenges in implementing effective teaching approaches to develop the necessary students' skills for the 21st century.
Understanding the feasibility and practicability of electronic modules based on bioinformatics as an educational tool in teaching of endocrinology
Authors: Nugroho Wahyu , Harlita  , Ramli Murni
Published: August 2024

Endocrinology is a subdiscipline considered one of the most difficult topics for students to understand. Endocrinology can be easier to learn by applying learning strategies that support problem-solving activities or conducting an experiment (practicum), such as by integrating bioinformatics. Bioinformatics can be delivered through digital-based learning media such as electronic modules. This study aims to determine the feasibility and practicality of using electronic modules based on bioinformatics as an educational tool in teaching endocrinology. The research participants involved experts (material, media, and language experts), lecturers, and students. Data were collected through questionnaires and then analyzed using descriptive statistical analysis. The findings showed that electronic modules based on bioinformatics are feasible and practical for use as educational tools in teaching endocrinology. This study implies that electronic modules based on bioinformatics can be a suitable learning media to support the learning process and become a learning media that can facilitate students to learn independently in endocrinology courses.
Between nature and community: Local perceptions of local residents on the degradation of the Maâmora forest, Morocco
Authors: Zahra Elmassmari Fatima , Slim Mostafa , Thami Daiboun
Published: August 2024

The Maâmora is the largest cork grove in Morocco and even the world, home to flourishing biodiversity. It plays an important role as a natural heritage for the local inhabitants and offers many ecosystem services. However, there is deforestation caused by various factors, some caused by humans and others by nature. We aim to assess the degree of awareness of the surrounding population of the Maâmora forest regarding the impact of these factors on socioeconomic life as factors of forest degradation. To carry out this task, we used a questionnaire containing 17 items relating to the perception of the degree of degradation and overexploitation of the forest. The results of this survey indicate that more than 75% of respondents see a decrease in forest area, tree density and changes in water resources. While more than 70% of people confirm that the Maâmora forest has been overexploited due to the collection of firewood and construction, this leads to the disappearance of certain species of economic or ecological interest. Age and educational level were strongly associated with the choice of these answers, as well as the link with the forest. In response to this threat to our forest heritage, the Ministry of Agriculture, Fisheries, Rural Development, Water and Forests has recently taken actions by adopting bill 52.20 aimed at establishing the National Agency for Water and Forests (ANEF). This agency will play a crucial role in the implementation of the Moroccan Forests strategy 2020-2030.
Fully automated real-time approach for human temperature prediction and COVID-19 detection-based thermal skin face extraction using deep semantic segmentation
Authors: Al-Azzawi Adil , Hussein Mohammed Khaleel
Published: August 2024

The COVID-19 pandemic caused by the coronavirus has affected every country. The World Health Organization has declared it a global health emergency by 2020. Early intervention provides a more effective cure and relieves patients of unnecessary intensive care from hospitals and other healthcare facilities. However, that requires an accurate method for early disease detection.  COVID-19 illness may eventually infect people, making it a severe condition. Research shows that COVID-19 pneumonia shares many clinical features with other forms of pneumonia, suggesting that COVID-19 can be a serious condition for those affected. The main symptom of the disease is high body temperature. Noncontact thermal imaging is one of the most important methods for measuring body temperature, although it has some performance limitations. Many of these thermal cameras are privately owned, not widely available, and are often owned by for-profit organizations. In this paper, we propose a real-time method for human temperature prediction and tracking based on facial skin temperature extraction for accurate COVID-19 case detection. The main idea of this paper is to use an automated deep-learning model for thermal skin temperature extraction. The optimization is based on using the deep semantic segmentation approach for fully automated thermal skin binary mask prediction using the thermal video only. The predicted mask is projected onto the original thermal video to extract the thermal skin mask, which is used to calculate the average thermal skin face temperature. The proposed deep semantic segmentation model is trained on the thermal skin binary mask dataset that is generated by using our first model a fully automated unsupervised learning approach for camera calibration and thermal skin binary mask extraction. The experimental results show that the proposed approach can automatically predict better binary skin-mak than our first model which leads to a very high-efficiency human temperature tracking using thermal videos only compared with the Ground Truth using the Speaking Faces thermal datasets.
Aktivitas Antimikroba Ekstrak Infusa Daun Bakau Rhizopora Sp. Terhadap Bakteri Staphylococcus aureus
Authors: Rahmawati Nur Annisa
Published: August 2024

This study aimed to evaluate the potential antimicrobial activity of Rhizophora sp. mangrove leaf infuse extract against Staphylococcus aureus bacteria. S. aureus is a pathogen often associated with human infections, and this research sought to uncover the leaf extract's ability to inhibit the growth of this bacterium. The research method involved the collection of Rhizophora sp. mangrove leaves and the preparation of infuse extract. Subsequently, antimicrobial activity testing was conducted using the disc diffusion method. The research findings showed that the mangrove leaf infuse extract had the capability to create growth inhibition zones in S. aureus cultures, indicating significant antimicrobial activity. The strong range of inhibition zone diameters at a concentration of 100% was 20.41 mm, at 80% concentration was 20.25 mm, and at 60% concentration was 19.33 mm
Sebaran suhu dan Salinitas di Perairan Kayo Pulau, Kota Jayapura
Authors: Umbekna Sara , Tuhumena Lolita , Muhammad Hisyam  , Huwae Jilian Risky
Published: August 2024

Temperature and salinity are oceanographic parameters that play an important role in physical, chemical and biological process in the sea, such as in mixing process, dissolved oxygen concentration and the distribution of marine organisms. This study aims to determine the distribution of temperature and salinity in the waters of Kayo Pulau, Jayapura City. The study was conducted in November 2023. Temperature and salinity were measured using a digital thermometer and hand refractometer. Water samples were taken at a depth of 1 m at 5 observation stations spread around Kayo Pulau Village. The study found, the temperature in the waters of Kayo Pulau ranged from 29.2-29.5°C, with an average temperature of 29.3°C. The salinity in Kayo Island waters is very high, ranged from 33.40-35.00%0, with an average of 34.28%0. The temperature and salinity in Kayo Pulau waters are still within the optimal range to support the survived of marine organisms
Faktor Penyebab Remaja Putri Menderita Anemia
Authors: Islamiati Diani , Nurhamidi Nurhamidi , Dewi Zulfiana
Published: August 2024

Latar Belakang : Anemia remaja putri saat ini masih tinggi, menurut Word Health Organization (WHO) (2015) prevalensi anemia berkisar 40-88%. Penyebab remaja putri memiliki risiko anemia karena haid setiap bulannya, serta cenderung menjaga penampilan untuk tetap kurus sehingga berdiet dan mengurangi asupannya. Tujuan: Mengetahui perbedaan pengetahuan, konsumsi tablet tambah darah dan pola konsumsi (enhancer dan inhibitor) zat besi pada kelompok remaja putri anemia dan non-anemia di SMK Garuda Mahadhika Banjarbaru. Metode: Penelitian observasional analitik dengan rancangan case-control. Sampel penelitian adalah sebagian siswi di SMK Garuda Mahadhika Banjarbaru sebanyak 36 sampel, dengan perbandingan 1:1 dengan teknik simple random sampling. Analisis data dilakukan dengan uji Mann Withney. Hasil: Berdasarkan hasil uji statistik didapatkan bahwa ada perbedaan pengetahuan (p= 0,000), ada perbedaan konsumsi tablet tambah darah (p= 0,000), ada perbedaan konsumsi enhancer dan inhibitor (p= 0,000) pada kelompok remaja putri anemia dan non-anemia. Kesimpulan : Remaja putri diharapkan untuk lebih aktif mencari informasi tentang anemia, meningkatkan kepatuhan konsumsi tablet tambah darah dan meningkatkan konsumsi enhancer serta mengurangi inhibitor demi mencegah anemia.
Hubungan Status Gizi, Tingkat Konsumsi Fe dan Tingkat Stres dengan Siklus Menstruasi Remaja
Authors: Salsabila Dina , Farhat Yasir , Nurhamidi Nurhamidi
Published: August 2024

Background: Women who have reached the age of puberty will experience menstruation that appears every month. One of the disorders of menstruation is menstrual cycle disorders. According to Riskesdas in 2010, it showed that irregular menstrual cycles in women aged 10-59 years in Indonesia reached 13.7%. Objectives: To determine the relationship of nutritional status, Fe consumption rate and stress level with menstrual cycle of adolecents at SMA Negeri 2 Banjarbaru. Methods: Nutritional status data were obtained through direct measurements, while data on Fe consumption rate, stress levels and menstrual cycles were obtained through questionnaires on Google Form. This type of research is analytic observational with a cross sectional approach. Data analysis using Chi Square correlation test Î±= 0.05. Results: Most of the experience normal menstrual cycle (65,4%), with good nutritional status (79,5%), rarely consume foods high in Fe (67,9%) and with stress level moderate (33%). Results of the relationship test showed that there was a relationship between nutritional status, Fe consumption rate and stress level with menstrual cycle of adolescents in SMA Negeri 2 Banjarbaru. Conclusions: Most of the experience normal menstrual cycle, with good nutritional status, rarely consume foods high in Fe, with stress level moderate. There was a relationship between nutritional status, Fe consumption level and stress level with menstrual cycle of adolescents in SMA Negeri 2 Banjarbaru.
Hubungan Sikap dan Konsumsi Junk Food dengan Konsumsi Sayur dan Buah pada Mahasiswa Jurusan Gizi
Authors: Aziza Kamalia Noor , Farhat Yasir
Published: August 2024

Background : The Physiological fulfillment of adolescents requires the fulfillment of adequate nutrition, including fruits and vegetables. However, their current diet has changed. They tend to choose fast food such as junk food which contains added sugar and fat in excessive amounts rather than consuming vegetables, fruit and milk. According to result of basic health research (Riskesdas) in 2018, the proportion of fruit / vegetable consumption per day in a week for people aged 5 years and over, according to the Regency / City of South Kalimantan Province, Banjarbaru City has a level of non-consumption reaching 11,79%, 1-2 portions a week reaching 78,96%, 3-4 servings a week reaches 8,64%, and more than 5 servings a week reaches 0,61%. Objectives : The purpose of this study was to determine the relationship between attitudes and junk food on the level of vegetable and fruit consumption among students majoring in nutrition at the Politeknik Kesehatan Kemenkes Banjarmasin. Methods : This type of research is an analytical observational study with a cross sectional approach. The population of this study were 294 students majoring in nutrition at the Health Polytechnic of the Ministry of Health, Banjarmasin. Sampling used 83 people with simple random sampling technique. This research was conducted using an online questionnaire with WhatsApp and Google Form. Data analysis using the Spearman Rank correlation test Î± = 0,05. Results : The results showed that the results of the correlation test using the Rank Spearman correlation test found that there was no significant relationship between attitudes and consumption of vegetables and fruits and there is a significant relationship between consumption of junk food and consumption of vegetables and fruit. Conclusions : Students who have low levels of vegetable and fruit consumption are expected to be able to apply the nutritional knowledge that has been learned in their daily life. In addition, they can raise awareness about the importance of eating vegetables and fruit.
Pengaruh Edukasi Hipertensi Menggunakan Media Video terhadap Pengetahuan, Sikap dan Perilaku Penderita Hipertensi
Authors: Zalfa Alya Anshari Zalfa Alya Anshari , Dewi Zulfiana , Widyastuti Hariati Niken
Published: August 2024

Hipertensi merupakan kondisi dengan meningkatnya konstraksi pembuluh darah, prevalensi hipertensi di Puskesmas Terminal Kota Banjarmasin merupakan urutan ke 1 tertinggi di Kota Banjarmasin dengan kasus 4.217 sehingga dilakukan upaya untuk menurunkan prevalensi hipertensi salah satunya dengan kegiatan penyuluhan. Tujuan penelitian mempelajari pengaruh edukasi hipertensi menggunakan media video terhadap pengetahuan, sikap dan perilaku penderita hipertensi studi di wilayah kerja Puskesmas Terminal, Kota Banjarmasin. Metode penelitian ini menggunakan eksperimen semu dengan rancangan pretest–postest. Terdapat 32 sampel terbagi kelompok eksperimen dan kontrol. Eksperimen yaitu penderita hipertensi yang mendapatkan penyuluhan media video, kontrol yang diberi leaflet. Sampel penelitian diambil dengan teknik Purposive Sampling. Data yang dikumpulkan karakteristik penderita Hipertensi, pengetahuan dan sikap dengan cara mengisi kuesioner. Perilaku dikumpulkan melalui wawancara recall 1 x 24 jam. Analisis data menggunakan uji wilcoxon. Hasil penelitian menunjukkan ada pengaruh penyuluhan terhadap pengetahuan pada kelompok eksperimen dan kontrol, ada pengaruh penyuluhan terhadap sikap pada kelompok eksperimen dan kontrol. Tidak ada pengaruh penyuluhan terhadap perilaku recall energi pada kelompok eksperimen sedangkan pada kontrol ada. Tidak ada pengaruh penyuluhan terhadap perilaku recall protein pada kelompok eksperimen sedangkan pada kontrol ada. Tidak ada pengaruh penyuluhan terhadap perilaku recall lemak pada kelompok eksperimen dan kontrol. Tidak ada pengaruh penyuluhan terhadap perilaku recall natrium pada kelompok  eksperimen sedangkan pada kontrol ada. Sebaiknya kegiatan penyuluhan dilakukan dengan menggunakan media yang berbeda-beda agar mengetahui media mana yang efektif. Peneliti menyimpulkan bahwa perilaku penderita hipertensi sulit untuk dirubah.
Pengetahuan, Pola Asuh dan Kebiasaan Makan Orang Tua terhadap Kesulitan Makan Usia 4-6 Tahun
Authors: Samiah  , Mahpolah  , Hariati Niken Widyastuti
Published: August 2024

Kesulitan makan yang biasa terjadi pada anak masih menjadi perhatian banyak orang tua. Faktor yang berpengaruh terhadap gizi seseorang adalah pola makan. Pola makan erat kaitannya dengan macam, jumlah dan komposisi makanan yang dikonsumsi setiap hari. Pemenuhan makanan yang baik bagi anak akan mempengaruhi status gizi pada anak. Menurut data World Health Organization (WHO) tahun 2019 menyatakan bahwa prevalensi kasus anak usia prasekolah underweight di dunia sebesar 15,7% dan anak usia prasekolah overweight sebanyak 6,6%. Penelitian ini bertujuan mengetahui pengetahuan, pola asuh dan kebiasaan makan orang tua terhadap kesulitan makan usia 4-6 tahun di PAUD Aba Rahmaniah Kecamatan Banjarbaru Utara. Jenis penelitian ini adalah observasional analitik dengan desain cross-sectional. Populasi dalam penelitian adalah semua ibu yang memiliki anak di PAUD Aba Rahmaniah Kecamatan Banjarbaru Utara dengan sampel 70 ibu yang diambil dengan teknik total sampling. Pengumpulan data dengan wawancara menggunakan kuesioner. Analisis data menggunakan uji korelasi Rank Spearman. Hasil penelitian menunjukkan tingkat pengetahuan ibu cukup (41,4%), pola asuh kurang (64,3%), kebiasaan makan orang tua kurang (58,6%). Analisis hasil uji korelasi Rank Spearman didapatkan ada hubungan pengetahuan (p<0,05), pola asuh (p<0,05) dan kebiasaan makan orang tua (p<0,05) terhadap kesulitan makan usia 4-6 tahun di PAUD Aba Rahmaniah Kecamatan Banjarbaru Utara. Disarankan kepada Puskesmas perlu peningkatan pendidikan gizi bagi para orang tua untuk perbaikan pola asuh anak.
Impaired Skeletal Development by Disruption of Presenilin-1 in Pigs and Generation of Novel Pig Models for Alzheimer’s Disease
Authors: Uh Kyungjun , Monarch Kaylynn , Reese Emily D. , Rodriguez Katherine , Yoon Junchul , Spate Lee D. , Samuel Melissa S. , Koh Sehwon , Chen Paula R. , Jarome Timothy J. , Allen Timothy A. , Prather Randall S. , Lee Kiho
Published: August 2024

Background:

Presenilin 1 ( PSEN1) is one of the genes linked to the prevalence of early onset Alzheimer’s disease. In mice, inactivation of Psen1 leads to developmental defects, including vertebral malformation and neural development. However, little is known about the role of PSEN1 during the development in other species.

Objective:

To investigate the role of PSEN1 in vertebral development and the pathogenic mechanism of neurodegeneration using a pig model.

Methods:

CRISPR/Cas9 system was used to generate pigs with different mutations flanking exon 9 of PSEN1, including those with a deleted exon 9 (Δexon9). Vertebral malformations in PSEN1 mutant pigs were examined by X-ray, micro-CT and micro-MRI. Neuronal cells from the brains of PSEN1 mutant pigs were analyzed by immunoflourescence, followed by image analysis including morphometric evaluation via image J and 3D reconstruction.

Results:

Pigs with a PSEN1 null mutation (Δexon9-12) died shortly after birth and had significant axial skeletal defects, whereas pigs carrying at least one Δexon9 allele developed normally and remained healthy. Effects of the null mutation on abnormal skeletal development were also observed in fetuses at day 40 of gestation. Abnormal distribution of astrocytes and microglia in the brain was detected in two PSEN1 mutant pigs examined compared to age-matched control pigs. The founder pigs were bred to establish and age PSEN1 ΔE9/+ pigs to study their relevance to clinical Alzheimer’s diseases.

Conclusions:

PSEN1 has a critical role for normal vertebral development and PSEN1 mutant pigs serves as novel resources to study Alzheimer’s disease.
Effect of Genetic Risk on the Relationship Between rs-fMRI Complexity and Tau and Amyloid PET in Alzheimer’s Disease
Authors: Jann Kay , Cen Steven , Santos Mariella , Aksman Leon , Wijesinghe Dilmini , Zhang Ru , Lynch Kirsten , Ringman John M. , Wang Danny J. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: August 2024

Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer’s disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk ( APOE ɛ4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOE ɛ4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.
High-Frequency Hearing Loss, Hippocampal Volume, and Motoric Cognitive Risk Syndrome in Older Adults in China: A Population-Based Study
Authors: Zhang Qinghua , Zhao Shicheng , Feng Jianli , Wang Shanshan , Song Lin , Han Qi , Cong Lin , Wang Yongxiang , Du Yifeng , Qiu Chengxuan
Published: August 2024

Background:

Little is known about the associations of hearing loss, hippocampal volume, and motoric cognitive risk syndrome (MCR) in older adults.

Objective:

We aimed to investigate the associations of hearing loss with MCR and hippocampal volume; and the interaction of hearing loss with hippocampal volume on MCR.

Methods:

This population-based cross-sectional study included 2,540 dementia-free participants (age≥60 years; 56.5% women) in the baseline examination of the Multimodal Interventions to Delay Dementia and Disability in rural China. Data were collected through face-to-face interviews, clinical examination, and laboratory tests. Hearing function was assessed using pure tone audiometry test. In the subsample ( n = 661), hippocampal volume was assessed on structural magnetic resonance images. Data were analyzed with logistic regression models.

Results:

In the total sample, MCR was diagnosed in 246 persons (9.7%). High-frequency hearing loss was significantly associated with an increased likelihood of MCR and slow gait. In the subsample, the restricted cubic spline plots indicated an inverted U-shaped nonlinear relationship between high-frequency hearing performance and hippocampal volume. Moreover, greater hippocampal volume was significantly associated with a deduced likelihood of MCR and subjective cognitive decline (SCD). In addition, there were statistical interactions of high-frequency hearing loss with hippocampal volume on MCR and slow gait ( p for interaction < 0.05), such that the associations were statistically significant only among participants free of high-frequency hearing loss.

Conclusions:

High-frequency hearing loss was associated with an increased likelihood of MCR in older adults. The hippocampus might play a part in the relationship of high-frequency hearing loss and MCR.
Development of a Digital Platform to Support Child Mental Health Care
Authors: Rainosek Erin , Whiteside Stephen P.H. , Biggs Bridget K. , Gloe Lilianne M.
Published: August 2024

Childhood mental health problems are a leading cause of disability and frequently go untreated. Barriers to children receiving the most effective care available include shortfalls in three areas: identification, referral to specialists, and delivery of evidence-based treatment (EBT). The current paper details an effort to develop a digital health intervention, the Mental Health Advisor (MHA), to increase the number of children with mental health problems who receive optimal care through identification, specialty referral, and fidelity to EBT. We present this pilot as a case example to help guide other efforts to improve mental health care through technology.
Feasibility of Calculating Indicators for Intensive Care Unit Antibiotic Use Based on Routine Electronic Health Record Data
Authors: Stegink Daphne , Roos-Blom Marie-José , Dongelmans Dave , de Keizer Nicolette
Published: August 2024

This study evaluated the feasibility of utilizing routinely collected EHR data to calculate pre-developed quality indicators on antibiotic use. Three out of four indicators were found feasible. Main barriers included local codes for lab tests and surveillance cultures and lack of data on empirical prescription. Future studies should include data from multiple ICUs to test the variations in QIs between ICUs.
Identifying Reusable Core Assets of Digital Health Apps
Authors: May Richard , Glauser Robin , Denecke Kerstin
Published: August 2024

Despite their variability, Digital Health Apps (DHAs) typically share functionalities (i.e. core assets) and can thus be considered as a family of similar products with unique features adapted to specific use cases. Objective: We aim to identify and model reusable core assets to facilitate the development of a number of similar, but adapted DHAs in the context of an initial product line engineering approach. Methods: To identify core assets, we apply a systematic analysis of six exemplary state-of-the-art DHAs. In an iterative process, they were modeled in a feature model. Results: We identified 14 core assets of DHAs out of which six are mandatory (i.e. required by each DHA) and eight are optional core assets (i.e. required by most DHAs, depending on the app complexity). Conclusions: We found that DHAs share common functionalities that could contribute to a more efficient development of the DHA, especially in terms of time and cost savings.
Strategies to Address Statin Medication Intolerance Among Patients at Risk of Cardiovascular Disease Identified Through Electronic Health Records: A Literature Review and Pooled Analysis
Authors: Rakhshanda Shagoofa , Liaw Siaw-Teng , Rhee Joel , Rye Kerry-Anne , Jonnagaddala Jitendra
Published: August 2024

Statins are a group of medications that lower lipid and are used for primary and secondary prevention of cardiovascular diseases (CVD). Patients can either be partially (15%) or completely (5%) intolerant to statins. Symptoms of statin intolerance can include muscle aches (myalgia), weakness, cramps, myopathy, diabetes mellitus, and elevated creatine kinase levels. Decreasing statin intolerance also improves statin adherence, which in turn results in lower number of CVD events among patients. Studies on statin intolerance is often embedded within studies of statin adherence. However, relevant data can be obtained from digital health systems. This preliminary literature review looks at studies from the past 10 years to identify and determine the effectiveness of strategies to address statin intolerance. The NLA definition for statin intolerance was used in this review. The initial search results on EMBASE, PubMed, SCOPUS, and CINAHL showed 91 articles and applying the inclusion and exclusion criteria, four articles were used in this review and pooled analysis. The study patients were identified through electronic health records. The pooled analysis was done using the Metafor package in R, applying a random-effect model to estimate pooled effect size. The findings suggest that using fixed dose combination therapy and switching from a lipophilic statin to a hydrophilic statin, while correcting metabolic abnormalities, or initiating evolocumab alongside statin can address statin intolerance. The overall relative risk (RR) was 0.40 (95% CI, 0.09 to 1.70) with I2 90%, and the overall odds ratio (OR) was 0.11 (95% CI, 0.01 to 1.59) with I2 94%, suggesting that the interventions work well in addressing statin intolerance. Since statin intolerance is has a vast range of effects, further research works may be done on exploring the possibility of using digital health systems to identify and provide targeted interventions to patients.
Gender and Geographical Representation on Editorial Board Members of Medical Informatics Journals
Authors: Mavragani Amaryllis , Eysenbach Gunther , Leung Tiffany I.
Published: August 2024

Previous work has suggested that gender and geographical distribution (affiliation) of Editors-in-Chief (EiC) and Editorial Board (EB) members are inequitable in representation of scientific communities, and could benefit from increasing diversity of representation. Specifically, previous studies suggest that male and ethnically white (or non-minoritized groups) are overrepresented. Such differences in representation may potentially influence the scientific and scholarly record. This paper aims to build on pre-existing literature by examining the diversity of representation among EiCs and EB members in the top (Q1) journals in the “Medicine-Health Informatics” category (ranked by SCImago Journal and Country Rank, or SJR) in terms of gender as assessed by genderize.io) and geographical distribution of affiliations. Preliminary findings are consistent with those of previous work on the topic: only 25% (8/32) of the EiCs in the selected journals are female, while females only represent 32.7% (426/1303) of the EB members across journals. Furthermore, the US is highly represented in EBs, with more than half of the members, i.e., 52.2% (698/1337), being US-affiliated. Present results suggest the need for an intentional approach to diversifying representation on editorial boards of medical informatics journals. Such intention can be seen as part of a call to action from important stakeholders, including medical informatics leaders and programs, journal management and publishers, and the medical informatics and scientific community more generally.
Report from Health Professionals and Cancer Patients: Experiences and Wishes from Clinical Practice About the Integration of Quality of Life with a Health App
Authors: Beutter Chantal N.L. , Berger Stephanie , Martens Uwe M. , Fegeler Christian
Published: August 2024

Advanced cancer treatments increase survival rates and with that the importance of Quality of Life (QoL). QoL is well studied in trials, but the transition to standard care is little. For this reason, we identified the challenges for a regular integration to conceptualize an applicable solution together with patients and health professionals (HP). We conducted two meetings based on the design thinking method. Two Physicians, one employee of cancer counseling centers, one psycho-oncologists, and five patients were included. Based on the discussions a system was conceptualized to solve current thresholds. All participants had experience with the documentation of QoL, but none had shared it digitally from home. Therefore, the main threshold was the lack of system for data transition between agents, followed by lack of time for HP and acceptance of QoL for patients. HP were mainly interested in data on the trend of QoL whereas patients preferred information on their activity, energy level and social contacts. The conceptualized solution is based on a health app on the patients’ side with a browser-based implementation for HP. Within the system, automatized data interpretation, alarm systems, support information, standardized input fields as an orientation for documentation with expandable options for specific restrictions as well as interinstitutional networking for HP to better refer patients to others was wished for. This article describes the concept of such a system developed with HP and patients. Implementation and transfer to clinical care has yet to be done.
Experiences of Decision Making and Attitudes Toward Digital Health Services Among Older Adults in Finland
Authors: Rosenlund Milla , Turja Tuuli , Jylhä Virpi , Saranto Kaija , Kuusisto Hanna
Published: August 2024

Shared decision making (SDM) is based on the clinical expertise of healthcare professionals and patients’ preferences and values. Digital health services may offer new possibilities for patient-generated data e.g. in SDM. This study aimed to assess older adults’ experiences of decision making in healthcare and attitudes toward digital health and social services. Data were collected via an online survey of 629 respondents. Results showed that digital services are considered beneficial, yet half of respondents needed guidance in their use. Many factors affect SDM and the perceived benefits of digital services. Based on our findings digital services are expected to provide guidance and individualised user experience. More research is needed to provide services with equitable access for people with special needs.
Synthesizing Clinical Data Warehouse Content for Enhanced External Collaboration: A Preliminary Proposal
Authors: Mouney Franck , Pierre-Jean Morgane , Delamarre Denis , Bouzille Guillaume , Cuggia Marc , Cabon Sandie
Published: August 2024

This paper introduces a novel approach aimed at enhancing the accessibility of clinical data warehouses (CDWs) for external users, particularly researchers and biomedical companies interested in developing and testing their solutions. The primary focus is on proposing a clinical data catalogue designed to elucidate the contents of CDWs, facilitating biomedical project launch and completion. The catalogue is designed to address three fundamental inquiries that external users may have regarding CDWs: “What data is available, how much data is present, and how was it generated?” Additionally, the paper showcases a prototype of the catalogue through a visualization example, utilizing data from the CDW of Rennes University Hospital.
Adapting a Patient-Centered Tuberculosis Digital Adherence Technology Intervention for New Patient Populations
Authors: Suyanto Agnes , Iribarren Sarah , Turner Anne M.
Published: August 2024

Tuberculosis (TB) intervention adaptation strategies can be optimized to inform digital health intervention refinement. With experience we improved our strategies during the refinement of tools to support individuals with active TB.
Development and Evaluation of a Data Quality Management System for the Korea Biobank Network
Authors: Oh Seol Whan , Kim Kihoon , Im Yun Seon , Choi Wona , Choi In Young
Published: August 2024

As the reliance on clinical epidemiological information from human specimens grows, so does the need for effective clinical information management systems, particularly for biobanks. Our study focuses on enhancing the Korea Biobank Network’s (KBN) system with data quality verification features. By comparing the quality of data collected before and after these enhancements, we observed a notable improvement in data accuracy, with the error rate decreasing from 0.1198% to 0.0492%. This advancement underscores the importance of robust data quality management in supporting high-quality clinical research and sets a precedent for the development of clinical information management systems.
The Effect of Antidepressants on Withdrawal in Patients with Alcohol Dependence: A Retrospective Study
Authors: Tomlin Crystal , Piracha Muhammad U. , Stephens Rachel , Tiosano Shmuel , Rangan Prahalad , Falls Zackary , Leonard Kenneth E. , Elkin Peter L.
Published: August 2024

The use of electronic health records has expanded in the past decades, with healthcare entities storing terabytes of patient health data. In this study, we investigated how these databases can be utilized to generate clinically relevant information. We used the Office of Addiction Services and Supports Client Data Systems data merged with the NYS Medicaid Data Warehouse to study the relationship of certain antidepressants on alcohol withdrawal (AW) rates in patients with alcohol dependence (AD). We found that in patients with AD, bupropion was associated with a significantly reduced rate of AW compared to selective serotonin reuptake inhibitors (SSRIs). This may be due to the ability of bupropion to inhibit dopaminergic reuptake. This retrospective study provides the advantage of being faster and less expensive than randomized controlled trials (RCTs).