bluuebunny/crossref_metadata_2025 huggingface dataset:
NMNAT1 Is a Survival Factor in Actinomycin D-Induced Osteosarcoma Cell Death
Authors: Kiss Alexandra , Csikos Csaba , Regdon Zsolt , Polgár Zsuzsanna , Virág László , Hegedűs Csaba
Published: August 2021

Osteosarcoma is a frequent and extremely aggressive type of pediatric cancer. New therapeutic approaches are needed to improve the overall survival of osteosarcoma patients. Our previous results suggest that NMNAT1, a key enzyme in nuclear NAD+ synthesis, facilitates the survival of cisplatin-treated osteosarcoma cells. A high-throughput cytotoxicity screening was performed to identify novel pathways or compounds linked to the cancer-promoting role of NMNAT1. Nine compounds caused higher toxicity in the NMNAT1 KO U2OS cells compared to their wild type counterparts, and actinomycin D (ActD) was the most potent. ActD-treatment of NMNAT1 KO cells increased caspase activity and secondary necrosis. The reduced NAD+ content in NMNAT1 KO cells was further decreased by ActD, which partially inhibited NAD+-dependent enzymes, including the DNA nick sensor enzyme PARP1 and the NAD+-dependent deacetylase SIRT1. Impaired PARP1 activity increased DNA damage in ActD-treated NMNAT1 knockout cells, while SIRT1 impairment increased acetylation of the p53 protein, causing the upregulation of pro-apoptotic proteins (NOXA, BAX). Proliferation was decreased through both PARP- and SIRT-dependent pathways. On the one hand, PARP inhibitors sensitized wild type but not NMNAT1 KO cells to ActD-induced anti-clonogenic effects; on the other hand, over-acetylated p53 induced the expression of the anti-proliferative p21 protein leading to cell cycle arrest. Based on our results, NMNAT1 acts as a survival factor in ActD-treated osteosarcoma cells. By inhibiting both PARP1- and SIRT1-dependent cellular pathways, NMNAT1 inhibition can be a promising new tool in osteosarcoma chemotherapy.
Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation
Authors: Kim Myoung Jun , Kim Hyuk Soon , Lee Sangyong , Min Keun Young , Choi Wahn Soo , You Jueng Soo
Published: August 2021

O-linked-N-acetylglucosaminylation (O-GlcNAcylation) performed by O-GlcNAc transferase (OGT) is a nutrient-responsive post-translational modification (PTM) via the hexosamine biosynthetic pathway (HBP). Various transcription factors (TFs) are O-GlcNAcylated, affecting their activities and significantly contributing to cellular processes ranging from survival to cellular differentiation. Given the pleiotropic functions of O-GlcNAc modification, it has been studied in various fields; however, the role of O-GlcNAcylation during osteoclast differentiation remains to be explored. Kinetic transcriptome analysis during receptor activator of nuclear factor-kappaB (NF-κB) ligand (RANKL)-mediated osteoclast differentiation revealed that the nexus of major nutrient metabolism, HBP was critical for this process. We observed that the critical genes related to HBP activation, including Nagk, Gfpt1, and Ogt, were upregulated, while the global O-GlcNAcylation was increased concomitantly during osteoclast differentiation. The O-GlcNAcylation inhibition by the small-molecule inhibitor OSMI-1 reduced osteoclast differentiation in vitro and in vivo by disrupting the translocation of NF-κB p65 and nuclear factor of activated T cells c1 (NFATc1) into the nucleus by controlling their PTM O-GlcNAcylation. Furthermore, OSMI-1 had a synergistic effect with bone target therapy on osteoclastogenesis. Lastly, knocking down Ogt with shRNA (shOgt) mimicked OSMI-1’s effect on osteoclastogenesis. Targeting O-GlcNAcylation during osteoclast differentiation may be a valuable therapeutic approach for osteoclast-activated bone diseases.
Nano-Particles Carried by Multiple Dynein Motors Self-Regulate Their Number of Actively Participating Motors
Authors: Halbi Gal , Fayer Itay , Aranovich Dina , Gat Shachar , Bar Shay , Erukhimovitch Vitaly , Granek Rony , Bernheim-Groswasser Anne
Published: August 2021

Intra-cellular active transport by native cargos is ubiquitous. We investigate the motion of spherical nano-particles (NPs) grafted with flexible polymers that end with a nuclear localization signal peptide. This peptide allows the recruitment of several mammalian dynein motors from cytoplasmic extracts. To determine how motor–motor interactions influenced motility on the single microtubule level, we conducted bead-motility assays incorporating surface adsorbed microtubules and combined them with model simulations that were based on the properties of a single dynein. The experimental and simulation results revealed long time trajectories: when the number of NP-ligated motors Nm increased, run-times and run-lengths were enhanced and mean velocities were somewhat decreased. Moreover, the dependence of the velocity on run-time followed a universal curve, regardless of the system composition. Model simulations also demonstrated left- and right-handed helical motion and revealed self-regulation of the number of microtubule-bound, actively transporting dynein motors. This number was stochastic along trajectories and was distributed mainly between one, two, and three motors, regardless of Nm. We propose that this self-regulation allows our synthetic NPs to achieve persistent motion that is associated with major helicity. Such a helical motion might affect obstacle bypassing, which can influence active transport efficiency when facing the crowded environment of the cell.
Curcumin Derivatives as Potential Mosquito Larvicidal Agents against Two Mosquito Vectors, Culex pipiens and Aedes albopictus
Authors: Matiadis Dimitris , Liggri Panagiota G. V. , Kritsi Eftichia , Tzioumaki Niki , Zoumpoulakis Panagiotis , Papachristos Dimitrios P. , Balatsos George , Sagnou Marina , Michaelakis Antonios
Published: August 2021

Vector-borne diseases have appeared or re-emerged in many Southern Europe countries making the transmission of infectious diseases by mosquitoes (vectors) one of the greatest worldwide health threats. Larvicides have been used extensively for the control of Aedes (Stegomyia) albopictus (Skuse, 1895) (Diptera: Culicidae) and Culex pipiens Linnaeus, 1758 (Diptera: Culicidae) mosquitoes in urban and semi-urban environments, causing the increasing resistance of mosquitoes to commercial insecticides. In this study, 27 curcuminoids and monocarbonyl curcumin derivatives were synthesised and evaluated as potential larvicidal agents against Cx. pipiens and Ae. albopictus. Most of the compounds were more effective against larvae of both mosquito species. Four of the tested compounds, curcumin, demethoxycurcumin, curcumin-BF2 complex and a monocarbonyl tetramethoxy curcumin derivative exhibited high activity against both species. In Cx. pipiens the recorded LC50 values were 6.0, 9.4, 5.0 and 32.5 ppm, respectively, whereas in Ae. albopictus they exhibited LC50 values of 9.2, 36.0, 5.5 and 23.6 ppm, respectively. No conclusive structure activity relationship was evident from the results and the variety of descriptors values generated in silico provided some insight to this end.
The Device–Object Pairing Problem: Matching IoT Devices with Video Objects in a Multi-Camera Environment
Authors: Tong Kit-Lun , Wu Kun-Ru , Tseng Yu-Chee
Published: August 2021

IoT technologies enable millions of devices to transmit their sensor data to the external world. The device–object pairing problem arises when a group of Internet of Things is concurrently tracked by cameras and sensors. While cameras view these things as visual “objects”, these things which are equipped with “sensing devices” also continuously report their status. The challenge is that when visualizing these things on videos, their status needs to be placed properly on the screen. This requires correctly pairing visual objects with their sensing devices. There are many real-life examples. Recognizing a vehicle in videos does not imply that we can read its pedometer and fuel meter inside. Recognizing a pet on screen does not mean that we can correctly read its necklace data. In more critical ICU environments, visualizing all patients and showing their physiological signals on screen would greatly relieve nurses’ burdens. The barrier behind this is that the camera may see an object but not be able to see its carried device, not to mention its sensor readings. This paper addresses the device–object pairing problem and presents a multi-camera, multi-IoT device system that enables visualizing a group of people together with their wearable devices’ data and demonstrating the ability to recover the missing bounding box.
Semi-Precise Analytical Method for Investigating the Liftoff Variation on the Hall Sensor in Metal Defect Sensing
Authors: Azad Ali , Lee Jong-Jae , Kim Namgyu
Published: August 2021

Hall-effect sensors are used to detect metal surface defects both experimentally and numerically. The gap between the specimen and the sensor, called the liftoff, is assumed to remain constant, while a slight misplacement of a sample may lead to incorrect measurements by the Hall-effect sensor. This paper proposes a numerical simulation method to mitigate the liftoff issue. Owing to the complexity of conducting precise finite-element analysis, rather than obtaining the induced current in the Hall sensor, only the magnetic flux leakage is obtained. Thus, to achieve a better approximation, a numerical method capable of obtaining the induced current density in the circumferential direction in terms of the inspection direction is also proposed. Signals of the conventional and proposed approximate numerical methods affected by the sensor liftoff variation were obtained and compared. For small liftoffs, both conventional and proposed numerical methods could identify notch defects, while as the liftoff increased, no defect could be identified using the conventional numerical method. Furthermore, experiments were performed using a variety of liftoff configurations. Based on the results, considering the threshold of the conventional numerical method, defects were detected for greater liftoffs, but misdetection did not occur.
Regional Cooperation in Marine Plastic Waste Cleanup in the South China Sea Region
Authors: Sun Jianping , Fang Chao , Chen Zhaohui , Chen Guoquan
Published: August 2021

This paper uses countries in the South China Sea Region (SCSR) as examples to study the level of regional cooperation in the marine plastic waste cleanup initiative. We designed a cooperation model to investigate the “cleanup system” from the Ocean Cleanup initiative to reduce marine plastic pollution. The non-cooperative game theory was applied to regional cooperation. The simulation results indicate that the plastic waste cleanup cooperation in the SCSR is related to the plastic trade network structure, the influence parameters of the Experience-Weighted Attraction learning model, and the economic effects. The results suggest that regional cooperation in the cleanup system in the SCSR is feasible, and it could create a significantly larger investment in the cleanup project than the current project attracts. Therefore, countries in the SCSR should adjust their laws and policies to make a good cooperative environment and to maximize the contribution to the marine plastic waste cleanup.
Possibilities of using infrared radiation in the food industry when processing raw materials for bakery production
Authors: Mitrofanova I. P. , Nikitin I.A. , Yakovlev A.N.
Published: August 2021

The article provides an overview of studies on the use of infrared radiation in the food industry. Examples of its effect on the quality of wheat grain, as well as baking properties and microbiological contamination of wheat flour are considered. The physical principles of operation of this technology and the properties of the applied method are analyzed.
History of kvass as a national drink
Authors: Ignatenko B.V. , Nikolaeva M.A. , Eliseev M.N.
Published: August 2021

The article presents the history of fermented bread kvass as a national Russian drink. The factors that influenced the periods of significant decrease in the consumption of kvass in the second half of the 19th and the end of the 20th centuries and the dynamics of growth in the production and consumption of kvass in the 2000s are considered. English version of the article on pp. 160-163 at URL: https://panor.ru/articles/history-of-kvass-as-a-national-drink/65947.html
A little about the classification and features of horticultural goods
Authors: Agapkin Aleksandr Matveevich
Published: August 2021

A brief classification and features of horticultural goods are provided. The purpose of the work is to interest the readers and encourage them to a more detailed study of horticultural goods. The article is intended for students and trainees of the commodity and trade profile. The material was prepared on the basis of classical works on commodity science, modern regulatory documents and publications of the author.
Expert examination of quality indicators of mayonnaise TM "Slavoliya"
Authors: Molokanova L.V. , Kudinova O.V.
Published: August 2021

The article presents the results of the expert examination of the quality of mayonnaise of TM "Slavoliya", OOO (LLC) "Slavoliya Group" according to organoleptic, physico-chemical and microbiological indicators.
Problematic aspects of the classification of food flavorings for customs purposes
Authors: Krishtafovich D.V. , Televko K.M.
Published: August 2021

This article highlights the problems associated with the peculiarity of the classifi cation of food flavorings in accordance with the commodity nomenclature of foreign economic activity of the Eurasian Economic Union. As it is known, food flavorings are now becoming increasingly important: they are massively added to almost all food products on the modern food market to improve the properties of these products: to add, change or enhance taste (aroma). In this regard, there is a need to unify regulatory documents for their classification, which directly affects the determination of the reliable code of the EAEU Commodity Nomenclature of Foreign Economic Activity and the corresponding customs duty rate.
Study of the amino acid composition of macaroni products under the influence of different storage temperatures
Authors: Tarasova I.A. , Tarasova E.A.
Published: August 2021

The article presents the studies of the amino acid composition in the samples of macaroni products by the method of chromatographic analysis. Amino acids were separated by ion exchange chromatography, reacted with ninhydrin, and their content was determined by photometric detection at a wavelength of 570 nm. Amino acid compositions of three samples of macaroni products stored at temperatures 20±2°C, 30±2°C and 40±2°C were investigated. The biological value of macaroni products proteins was determined by a comparative method for analyzing the quantitative content of amino acids with the ideal protein scale proposed by the FAO/WHO Committee. The limiting amino acids for macaroni products after 12 months of storage are valine, threonine and lysine, with the lysine content being the lowest.
Botanical and commodity characteristics of the ramson
Authors: Ryazanova O.A. , Nikolaeva M.A , Kleschevskiy Yu.N.
Published: August 2021

The article discusses the botanical and commodity features of the ramson (or bear’s garlic), its biology and range, economic value, use in folk medicine and home cooking, as well as benefits and harms. Identifying features and indicators regulated by GOST, conditions and methods of storage are provided.
Computer system for monitoring nutritional status in the Nutrition Diary with internet access
Authors: Portnov N.M.
Published: August 2021

A computer system was introduced into the educational process for keeping food diaries, anthropometric measurements and calculating physical activity with an access via the Internet in self-service mode. The system integrates a database of foods and nutrients, types of physical activity, average population consumption rates. The system is easy to use, does not require prior deployment, and provides hands-on exercises for undergraduates, postgraduates and other students to develop skills for practical assessment of personal nutritional status and assessment of actual nutrition. It is recommended for use in the educational process, for developing practical skills in a healthy lifestyle and conducting massive observations of actual nutrition for scientific research purposes.
Nanostructured glucosamine sulfate: properties and uses in the production of functional foods extending life
Authors: Krolevets A.A. , Myachikova N.I. , Binkovskaya O.V. , Glotova S.G. , Semichev K.M. , Mamaeva E.M. , Golubkova K.V.
Published: August 2021

The paper presents the properties of nanostructured glucosamine sulfate and its application for the production of functional food products that extend life on the example of fermented milk products (yoghurts, kefir, fermented baked milk, sour cream, cottage cheese), marmalade, ice cream and bakery products. Data on the self-organization and size of nanostructured glucosamine sulfate using the NTA method are presented.
Development of diets for personalized nutrition of schoolchildren with diseases of blood, metabolism and diabetes
Authors: Vasyukova A.T.
Published: August 2021

The daily diet of schoolchildren in boarding schools on a round-the-clock basis consists of five meals a day. It includes breakfast, lunch, afternoon tea, dinner and a second dinner at 21.00. The calorie content of this diet differs from the indicators of the physiological need and requirements for the organization of nutrition specified in SanPiN 2.4.5.2409-08, for the nutrition of children and adolescents over 1000 kcal. The calculation of the two-week menu was carried out on the basis of the order of the Ministry of Education and Science of the Russian Federation No. 454 dated 05.24.2017 “On the approval of the norms and procedure for providing free meals, a free set of clothes, shoes and soft equipment for minors in federal institutions of the system for the prevention of neglect and juvenile delinquency at the expense of the federal budget”. The purpose of the study was to develop a menu of complete rations for the nutrition of schoolchildren in closed boarding schools. The menu was made taking into account the seasonality: spring-summer and autumn-winter. The age group of adolescents was chosen from 11 to 18 years old. Recommendations for the nutrition of children in boarding schools are extended throughout the Russian Federation. As a result of the development of complete food rations, it has been found that the menu includes foods with higher calories and with an increased portion yield (second courses, side dishes, bread). The menu includes products with a high content of vitamins and minerals. The inclusion of potatoes in the diet, which exceeds the indicators of SanPiN 2.4.5.2409-08 for this group of products by more than 2 times, will not only saturate the body with carbohydrates, but also microelements, especially lithium, which will have a calming effect on the nervous system of the child's body. A variety of juices, fresh fruits and vegetables in year-round consumption will help shape the vital functions of the body. In addition, the introduction of meat, fish and fermented milk products into the diet will ensure growth and physical development.
Properties of nanostructured silver nitrate and its use in antimicrobial packaging
Authors: Krolevets A.A. , Lyakhovchenko N.S. , Senchenkov V.Yu. , Sirotin A.A. , Semichev K.M. , Mamaeva E.M.
Published: August 2021

Data on the study of nanostructured silver nitrate by the NTA and self-organization method are presented. It is shown that silver nitrate nanocapsules are formed due to non-covalent interactions, which is characteristic of self-assembly. The average size of nanocapsules ranges from 117 to 149 nm, and the geometry of nanocapsules depends on the nature of the shell. Thus, in sodium alginate, it approaches a spherical shape, and in guar gum — an ellipsoid.
Commodity expert research of liquid laundry detergents
Authors: Zolotareva V.V. , Popova O.S.
Published: August 2021

The article is devoted to commodity expert research of liquid laundry detergents entering the domestic market. Studies of labeling, composition and quality indicators of liquid detergents were carried out.
Problematic aspects of nectars classification for customs purposes
Authors: Krishtafovich D.V. , Karaulova A.N.
Published: August 2021

The article highlights the problems of the classification of nectars in accordance with the commodity nomenclature of foreign economic activity of the Eurasian Economic Union; possible ways to solve them are suggested.
Notes on Russian civilization
Authors: Pelipenko A.A.
Published: August 2021

Philosophical and cultural research on the place and role of Russian civilization and culture in the history of Europe and Asia. Based on the analysis of extensive factual material related to geographical, demographic, ethno-historical and other aspects of comparison, the author comes to the conclusion that it is impossible to be satisfied with reducing the fundamental historical-dialectical complementarity of the western and eastern civilizational systems to a simple sum of their features (it is also necessary to take into account the Byzantine influence). According to the author, in Russia, under the veil of monotheism, the dualistic, Manichean (in a broad sense) foundations of culture emerge with particular clarity.
National cultural heritage and its originality
Authors: Flier A.Ya.
Published: August 2021

The problem of the complex nature of the cultural identity of the local historical societies, including social, religious, political and ethnic identity backbone traits, situational dominance with each type. However, in different historical periods it has been a predominance of certain types. Analyzed the most common (frequency) algorithm for the formation of local identity features.
Development of an interactive activity for children from the point of view of team building
Authors: Davydova S.A.
Published: August 2021

Sofia Davydova, Senior Researcher at the Marina Tsvetaeva House-Museum, tells about the peculiarities of developing interactive programs for younger students in a literary museum and the successful experience of involving colleagues in the process.
On the settlement of the grounds, conditions and procedure for the separation of a child from the family
Authors: Ponkin I.V.
Published: August 2021

Conclusion on the draft federal law № 986679-7 “On Amendments to Certain Legislative Acts of the Russian Federation”, introduced on July 10, 2020 to the State Duma of the Russian Federation by the Deputy of the State Duma P.V. Krasheninnikov and Senator of the Russian Federation A.A. Klishas.
The Stanislavsky system plays an important role in the theater of Vietnam
Authors: Man Hong Dao
Published: August 2021

K.S. Stanislavsky plays an important role in the theater of Vietnam. Konstantin Sergeevich Stanislavsky (real name Alekseev; 1863–1938) — actor, director, theater teacher, founder and director of the Moscow Art Theater (Moscow Art Theater). People's Artist of the USSR (1936). An activist, thinker and major theater theorist, he, on the basis of modern science, created a school of theatrical art — the Stanislavsky generation. In addition to a successful psychological approach to the performing arts, he also contributed greatly to the formation of progressive art and art for the people.

English version of the article on pp. 280-285 at URL: https://panor.ru/articles/stanislavskis-system-plays-an-important-role-in-vietnamese-theatre/65897.html
Interactive excursion-play “In search of a map of Clio” on objects of cultural heritage of ancient Chersonesos. Part 1
Authors: Dmitrieva L.V.
Published: August 2021

The proposed scenario of the interactive excursion-performance is designed for a children's audience of 6–9 years. The task of the excursion-performance is to immerse the historical and cultural environment of the ancient policy through the participation of the child in gaming cognitive activity. The project is part of the academic partnership program of the Russian State Pedagogical University named after A.I. Herzen with the historical and archaeological museum-reserve “Chersonesos Tauric” and is implemented during visiting summer practices of bachelors of the Department of Theory and History of Culture.
School–church relations in the 1990s-2000s: social partnership or temporary cooperation
Authors: Pigoreva O. V.
Published: August 2021

The article reveals the peculiarities of the relationship between the Russian system of general education and the Russian Orthodox Church as a signifi cant social institution in a diffi cult period of political and economic transformations for Russia. The factors of the school's appeal to cooperation with the Church are substantiated, the mechanisms of formation and regulatory settlement of contractual relations, public assessment are revealed.
The fight of Armenia against COVID-19 in the context of international cooperation
Authors: Tamamyan M. A.
Published: August 2021

The article is devoted to the study of methods of combating coronavirus infection in the Republic of Armenia in the context of international cooperation. Attention is focused on the interaction of country with international organizations to overcome the pandemic in the country. This paper presents the author's table based on the analysis of the mass media in order to summarize the full range of cooperation between the Government of Armenia and external actors during the COVID-19. The article emphasizes the importance of creating an anti-crisis committee to combat coronavirus, as well as the need to increase funding for the health system.
Technological features of PR-management of political processes in the crisis (on the example of Armenia)
Authors: Petrosyan E. K.
Published: August 2021

Anti-crisis PR is usually the most difficult area of public relations. The issues of practical anti-crisis PR are related to the theoretical and methodological problems that exist in this area. This article discusses attempts at anti-crisis management at present. The activities of the authorities to overcome the reputational crisis are presented.
Personal formation — obstacles and the goal
Authors: Makarova E. V.
Published: August 2021

This article considers the issue of personality. The article analyzes the ways of personality formation. It also examines the issue of obstacles that may be encountered on the path of personality formation.
Remuneration as one of the personnel management functions in the healthcare sector
Authors: Chanysheva Ekaterina Vladimirovna
Published: August 2021

The article is devoted to highlighting the main provisions of the system of remuneration of medical personnel as one of the key functions of personnel management in the healthcare sector. The author highlighted and substantiated that one of the important components of the success of the implementation of an effective system of financing the health sector is the change in the conditions of remuneration of medical workers, with the focus on the volume and quality of performed work.
The analysis of the implementation efficiency of programs for the elderly (on the example of Moscow)
Authors: Karpunina Anastasiya Vladimirovna , Karimova Liliya Sultanovna
Published: August 2021

This article examines the effectiveness of the implementation of programs for the elderly using the case of the city of Moscow. To analyze the efficiency of the implementation of the programs, a study was carried out on the territory of the State Budgetary Institution of the Territorial Center for Social Services "Tsaritsinsky".
Digitalization of the main spheres of public life in modern Russia: problems and risks
Authors: Kudryavtseva Mariya Viktorovna
Published: August 2021

The article shows the role of the development of information and computer technologies and the process of digitalization in various spheres of public life. It is noted that in such conditions information becomes one of the key resources. It is emphasized that for the modern society in the context of accelerating scientific and technological progress, it is becoming more and more difficult to critically comprehend the constantly increasing information flows. Virtual space offers tremendous opportunities for influencing public consciousness. In the context of the issue under consideration, some negative consequences are noted, including for the evolution of the mental sphere of the population. The article demonstrates important strategic directions for the development of the information society in modern Russia. It is emphasized that the processes of digitalization of the public life spheres and the new risks associated with it pose special tasks for modern social policy, in particular, in matters of purposefully increasing the level of information culture of the population, the quality of human capital and preparing society for global technological changes.
From the history of the formation of social conflictology
Authors:   Ryazan State University named after S. A. Esenin, Sukhov Anatoliy Nikolaevich
Published: August 2021

This article examines the essence of the socio-psychological approach to understanding conflicts. The chronology of the development of social conflictology is objectively presented and restored in full, taking into account the contribution of those researchers who actually stood at its origins. The subject of the theory of social conflictology includes the patterns of conflict occurrence and manifestation. It analyzes the difficulties that occur in defining the concept, structure, dynamics and classification of social conflicts. Social conflictology is developing intensively: general theoretical prerequisites and foundations for creating a coherent theory have been created. It contributes to the development of optimal social policies and the professional training of social workers.
Sustainable development strategy: education in the digital age
Authors: Gunzenova Karina Vasilievna , Yantranov Aleksandr Evgenievich , Khandarov Fedor Vladimirovich
Published: August 2021

The modern global civilization is at the stage of the formation of the information society. The scientific and technological revolution, accentuation of the services production sphere, and growing importance of information resources determine the special significance of education as a driving force of social progress. This work is devoted to the analysis of the role of education in achieving the goals of sustainable development, in socio-economic development, its features during the period of information transformation of society, and key principles that contribute to solving the challenges of our time.
Foster family as one of the forms of family placement of orphan children
Authors: Salmorbekova Rita Bobuevna
Published: August 2021

This article examines foster family as one of the forms of institutions, which from the first days of its formation provides care for orphans who were left without parental custody. According to the authors, the process of introducing the institution of the foster family was determined by objective factors, such as the need to accommodate children who were returned from other countries. For the development of this institution in Kyrgyzstan, the process of reforming the entire childcare system that has existed since the Soviet times has begun.

English version of the article on pp. 241-244 at URL: https://panor.ru/articles/foster-family-as-one-of-the-forms-of-life-order-for-orphan-children/65933.html
Social and charitable activities of knyaz Alexander Nevsky
Authors: Kryuchkova Irina Mikhailovna , Ignatova Anna Andreevna
Published: August 2021

Power is a heavy, but great cross, which not every person is capable of carrying. It is both the right to decide the fate of the country and people, and a great responsibility. This is the choice to serve one’s people, accompanied by numerous trials and overcoming of considerable life challenges. With the words «power» or «ruler», we see the image of a person endowed with a life grasp and willpower, who always retains a fi rmness of mind and is not afraid to oppose anyone. If he is gifted with the talents of a commander, strategist, politician and diplomat, the power is often able to shift all spiritual values to the background, and to put forward material desires and the possibilities of their realization. That is why, with all the fullness of one’s power, it is important to remain a virtuous, merciful and humane person. However, history shows that even in our Orthodox land such statesmen are very rare. Alexander Nevsky is a striking example of a great, humane and just ruler. A great number of works of both church and secular nature have been written about the noble knyaz. Meanwhile, his outstanding personality will not cease to attract attention, and after hundreds of years, this topic will always be relevant to us, especially from the point of view of the social orientation of his activities.
The concepts of Theological Principles in morality literatures and in the Holy Bible
Authors: A Bavliance
Published: August 2021

In the praise of the Lord who creates the world, the scriptures of the eighteen following books of the Sangamamaruviya period, and the Holy Book of Christianity, the Holy Book of Christianity, are of the Lord. This article explains that humanity is cultivated by the praise of sovereignty, removes evils, and directs the way of good ness. In the article, the article explains the importance of appreciating the nature of God and the system of worship of God, the benefits and the virtues of the sovereignty, that the world is the creation of the Lord and that the atom will not move without him.
Temas e questões para uma história da edição de quadrinhos na América Latina
Authors: Gomes Ivan Lima
Published: August 2021

Desde um ponto de vista histórico, encontra-se uma quantidade expressiva de revistas ilustradas, jornais, álbuns e graphic novels que permitem apontar a presença marcante da história em quadrinhos na América Latina. No entanto, ela continua sendo pouco pesquisada desde uma perspectiva da história editorial. Nosso ensaio buscará desenvolver temas que nos permitam pensar a materialidade dos quadrinhos na região a partir de um diálogo com campos como a história do livro e da leitura. Alguns quadrinhos publicados ao longo do século XX serão tomados como estudos casos, para discutir aspectos específicos relacionados à edição – tipografia, relação entre imagens / textos, apropriações culturais e introdução dos quadrinhos em projetos literários – com vistas a uma interpretação das peculiaridades históricas presentes nos quadrinhos da região. Consideramos possível apontar que tais elementos são fundamentais para o estabelecimento de uma expressão latino-americana dos quadrinhos a partir de uma abordagem transnacional.
Aproximação à escola discursiva dos Robinsons
Authors: Bonomo Daniel
Published: August 2021

O objetivo do texto é contribuir para a definição de uma escola discursiva fundada por Daniel Defoe em Robinson Crusoé, há trezentos anos. A hipótese de que o título inaugura uma tradição importante para o desenvolvimento do romance como gênero é sustentada pela observação de sua economia formal e de seus prováveis efeitos de leitura, que se transformam no tempo e nas diferentes realizações que repõem o modelo em novos contextos, mais ou menos distantes do original. Assim aparecem, aqui, além do primeiro e do segundo Robinson de Defoe, interpretações de O Robinson suíço (Johann David Wyss), A escola dos Robinsons (Júlio Verne), Suzana e o Pacífico (Jean Giraudoux), Sexta-Feira ou os limbos do Pacífico (Michel Tournier), A vida sexual de Robinson Crusoé (Michel Gall) e A invenção de Morel (Adolfo Bioy Casares), que representam configurações narrativas desiguais, mas relevantes para o entendimento em perspectiva das continuidades em jogo.
Tendencias gerenciales en organizaciones colombianas, mirada panorámica en investigaciones doctorales
Authors:   Universidad Benito Juárez, Alcántara Gutiérrez María Esther , Ríos Obando Julián Andrés ,   Universidad Autónoma Latinoamericana, Ríos Obando José Fabían ,   Universidad Santiago de Cali, Vargas Taborda Libardo Carlos ,   Universidad La Gran Colombia, Sánchez Vásquez Lina Marcela ,   Universidad Autónoma Latinoamericana, García Londoño Martha Lucía ,   Universidad La Gran Colombia
Published: August 2021

El libro Tendencias gerenciales en organizaciones colombianas, una mirada panorámica en investigaciones doctorales surge como producto de las investigaciones realizadas en el Doctorado en Administración Gerencial de la Universidad Benito Juárez de México. La experiencia en este nivel formativo, permitió a los doctorandos abordar problemáticas propias de las organizaciones colombianas, por ser este el país de origen de los investigadores, quienes han encontrado en aspectos que desde la innovación, la gestión, las tendencias administrativas y los retos de contexto, implican la confluencia de factores que, todos ellos, posibilitan el abordaje y generación de propuestas teóricas y metodológicas para contribuir a la solución de aspectos afines a este campo del conocimiento administrativo.
Automatic Generation Control Considering Uncertainties of the Key Parameters in the Frequency Response Model
Authors: Liu Likai , Hu Zechun , Mujeeb Asd
Published: August 2021

The highly fluctuated renewable generations and electric vehicles have undergone tremendous growth in recent years. The majority of them are connected to the grid via power electronic devices, resulting in wide variation ranges for several key parameters in the frequency response model (FRM) such as system inertia and load damping factor. In this paper, an automatic generation control (AGC) method considering the uncertainties of these key parameters is proposed. First, the historical power system operation data following large power disturbances are used to identify the FRM key parameters offline. Second, the offline identification results and the normal operation data prior to the occurrence of the disturbance are used to train the online probability estimation model of the FRM key parameters. Third, the online estimation results of the FRM key parameters are used as the input, and the model predictive-based AGC signal optimization method is developed based on distributionally robust optimization (DRO) technology. Case studies conducted on the IEEE 118-Bus System show that the proposed AGC method outperforms the widely utilized PI-based control method in terms of performance and efficiency.
ABO Blood Group System and Periodontal Disease Indices: A Cross-Sectional Study in Greek Adults
Authors: Chrysanthakopoulos Nikolaos
Published: August 2021

Introduction: Periodontal disease (PD) development has been associated with the presence of causative microorganisms, host immunity and risk factors, whereas the types of periodontal diseases are characterized by interactions between host and bacteria. Moreover, ABO blood groups are the most investigated erythrocyte antigen system. However, a small number of researches have been focused on the possible associations between ABO blood groups and periodontal diseases. Methods: A cross-sectional, epidemiological study was carried out on 854 individuals, 404 males and 450 females, aged 45 to 77. The study sample was interviewed and underwent an oral and dental clinical examination. The assessment of the possible associations between several indices of PD, such as Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) as dependent variables and ABO blood groups A, B, AB, and O as independent ones was carried out by using a multiple regression analysis model. Results: Individuals with blood group A [OR= 2.94, 95% CI = 1.27-3.96] and B [OR= 2.66, 95% CI = 1.11-3.87] were significantly associated with the risk of developing deeper periodontal pockets (PPD) and worse values of attachment loss (CAL) [OR= 2.42, 95% CI= 1.37-3.85] and [OR= 2.31,95% CI=1.25-3.68], respectively. However, no significant associations were recorded between ABO blood groups and BOP [OR= 1.04, 95% CI= 0.92-1.18]. Conclusion: A significant association was revealed between A and B blood groups and deeper periodontal pockets and worse attachment loss, whereas no associations were observed between ABO blood groups and bleeding of probing.
Satisfactory Rapid Response to Xultophy Associated with Meal Tolerance Test (MTT) by Carbohydrate Loading
Authors: Bando Hiroshi
Published: August 2021

The case is a 69-year-old male patient with Type 2 Diabetes Mellitus (T2DM) for 21 years. His diabetic control was not so satisfactory, and his HbA1c value increased in spring 2021. Then, he started Xultophy (IDegLira), which includes a fixed ratio of two agents of basal degludec and liraglutide. Just after providing Xultophy, the daily profile of blood glucose decreased from 179-400 mg/dL to 112-171 mg/dL, with remarkable clinical efficacy. He usually takes 80g of carbohydrates in breakfast, and the meal tolerance test (MTT) was challenged. As carbohydrate loading was given 100-75-50-0%, postprandial hyperglycemia at 60-min showed 277-219-159-133 mg/dL, respectively.
Current Data on Lower Prevalence and Age-Related Aggravation of COVID-19 in Japan
Authors: Bando Hiroshi
Published: August 2021

Pandemic COVID-19 has been crucial problem worldwide, and authors have reported less prevalence and excess death in Japan. The Ministry of Health, Labour and Welfare of Japan presented COVID-report of July 2021 Edition. Among them, the number of people diagnosed with COVID-19 in Japan was 796,835 until July 1, 2021, which is equivalent to 0.6% of the total population. Aggravation rate of COVID-19 increases remarkably with aging. The result shows 1, 4, 10, 25, 47, 70< in 30s, 40s, 50s, 60, 70s, 80s< years old, respectively. In contrast, it shows 0.5, 0.2, 0.3 in <9, 10-19, 20-29 years, respectively.
Emergency Transcatheter Aortic Valve Implantation in A Patient with The Assistance of Intra-Aortic Balloon Pump
Authors: Xu Yan , Zhang Pengkun , Fang Dengfeng
Published: August 2021

Surgical aortic valve replacement (SAVR) is considered the gold-standard treatment for patients with severe aortic valve stenosis (AS), yet 30% are considered inappropriate for SAVR on account of the advanced age and multiple comorbidities. Transcatheter aortic valve implantation (TAVI) provides an option for high-risk patients with severe AS, especially for those accompanied with acute cardiogenic shock and multiple organ dysfunction. Herein, we presented a case of a patient resuscitated successfully with TAVI in combination with intra-aortic balloon pump.
Purification and biochemical characterization of polyphenol oxidase from seeds of melon (Citrullus colocynthis)
Authors: Sanni David Morakinyo , Adeseko Catherine Joke , Bamidele Samuel Olufemi
Published: August 2021

Polyphenol oxidase (PPO) is an enzyme that is responsible for the enzymatic browning of fruits and vegetables. This is generally undesired process and need to be prevented in food technology. PPO from seeds of Citrullus colocynthis was purified, the physicochemical properties such as effects of pH and temperature, substrate specificity, effects of inhibitors and cations on PPO activity and the kinetic parameters for four substrates namely, catechol, L-DOPA, gallic acid and tyrosine, were determined. The purification steps resulted in 41-fold with 10 % yield, and the optima pH and temperature values for PPO from C. colocynthis were found to be pH 7.0 and 60 °C, respectively using catechol as substrate. About 9 % enzyme initial activity was retained after 60 min of incubation at 80 °C, and the apparent molecular weight was determined as 42 kDa by partially denaturing SDS-PAGE. PPO activity was inhibited by ascorbic acid, SDS and certain divalent (Ca2+, Zn2+, Mg2+ and, Fe2+) and monovalent (Na+) metal. Moreover, purified enzyme solution showed diphenolase activity toward catechol, gallic acid, L-DOPA and monophenolase activity toward tyrosine, therefore, tyrosinase was identified as the only one PPO in C. colocynthis seeds. This study revealed the use of temperature above 80 °C to inhibit PPO activity during processing and storage of melon seeds.
HUBUNGAN PERSONAL HYGIENE SANTRI DENGAN KEJADIAN SKABIES DI PONDOK PESANTREN AS – SYAFI’IYAH SIDOARJO TAHUN 2020
Authors: Novitasari Devinda , . Suprijandani , Ferizqo Ferdian Akhmad
Published: August 2021

Penyakit skabies merupakan penyakit yang disebabkan oleh infestasi sarcoptes scabies, hal ini dikarenakan kurangnya memelihara kebersihan diri (personal hygiene). Personal hygiene meliputi : kebersihan kulit, kebersihan  tangan dan kuku, kebersihan kaki, kebersihan pakaian, kebersihan handuk, dan kebersihan tempat tidur. Skabies menempati posisi ke – 2 dari 5 penyakit terbesar di Pondok Pesantren As – Syafi’iyah. Penelitian ini bertujuan untuk mengetahui hubungan personal hygiene santri dengan kejadian skabies di Pondok Pesantren As - Syafi’iyah Sidoarjo tahun 2020.         Penelitian ini menggunakan studi analitik, jenisnya observasional dengan pendekatan case control. Variabel yang diteliti ialah : kebersihan kulit, tangan, kuku, kaki, pakaian dan handuk. Sampel yang diambil sebanyak 66  responden sakit skabies dan 66 sebagai kontrol, dengan menggunakan teknik random sampling. Data dikumpulkan melalui observasi dan wawancara. Analisis data ditunjukkan dengan uji chi square.      Hasil penelitian menunjukkan sebanyak 15 responden (11,4%) kurang menjaga kebersihan kulit, lalu 19 responden (14,4%) kurang menjaga kebersihan tangan dan kuku, sebanyak 20 responden (15,2%) kurang menjaga kebersihan kaki, kemudian 19 responden (14,4%) kurang menjaga kebersihan pakaian, dan sekitar 17 responden (12,9%) kurang menjaga kebersihan handuk.      Kesimpulan ada hubungan antara kebersihan kulit dengan kejadian skabies (p-value = 0,00), terdapat pula hubungan antara kebersihan tangan dan kuku dengan kejadian skabies (p-value = 0,00), kejadian skabies juga dipengaruhi oleh kebersihan kaki (p-value = 0,01), kebersihan pakaian (p-value = 0,03), dan kebersihan handuk (p-value = 0,06). Pengelola Pondok pesantren perlu mengadakan  penyuluhan tentang kebersihan diri. Sanitarian dapat berperan sebagai penyuluhnya. Seluruh santri hendaknya menerapkan perilaku hidup bersih dan sehat (PHBS).
The Urgency of Protection House for Women Victims of Violence
Authors: Surayda Helen Intania
Published: August 2021

Kekerasan terhadap perempuan saat ini masih banyak terjadi di masyarakat. Memberikan perlindungan dari segala bentuk diskriminasi dan kekerasan merupakan kewajiban negara sebagai wujud pelaksanaan falsafah negara serta kewajiban menjalankan konstitusi dan undang-undang.  Sedangkan kekerasan adalah salah satu persoalan bangsa dan negara yang mendesak untuk dibenahi, karena kekerasan bertentangan dengan falsafah bangsa, hukum tertinggi di Indonesia, dan juga berdampak buruk pada kehidupan korban serta kelangsungan kehidupan bangsa ke depan. Perlindungan korban diartikan sebagai suatu perlindungan yang diberikan untuk mencegah seseorang menjadi korban serta perlindungan untuk memperoleh jaminan hukum atas penderitaan berupa pemulihan nama baik maupun pemulihan keseimbangan batin. Berdasarkan permasalahan di atas, maka yang menjadi fokus pada penelitian ini adalah bagaimana rumah perlindungan bagi perempuan korban kekerasan. Untuk menjawab permasalah tersebut dilakukanlah penelitian dengan metode pendekatan yuridis normatif dengan spesifikasi penelitian deskriptif analitis. Jenis data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Dari penelitian yang dilakukan diperoleh temuan bahwa perempuan korban kekerasan memerlukan rumah perlindungan sebagai upaya pemulihan dan reintegrasi social sesuai dengan tahapan kebutuhan korban. Rumah perlindungan tersebut memiliki pelayanan khusus. Pelayanan khusus yang dimaksud adalah tempat perlindungan dan tempat pemulihan. Pemerintah memiliki kewajiban dalam penyelenggaraan rumah perlindungan bagi perempuan korban kekerasan.