bluuebunny/crossref_metadata_2025 huggingface dataset:
PERFIL DOS PACIENTES COM INCONTINÊNCIA URINÁRIA ATENDIDOS EM UM PROJETO DE RESPONSABILIDADE SOCIAL
Authors: Queiroz Caio Ramon , Furtado Jose Henrique de Lacerda , Matos Wedla Lourdes Rebouças , Beuttenmüller Leila , Nogueira Andréa Nóbrega Cirino
Published: March 2022

Introdução: A incontinência urinária (IU) pode ser definida como qualquer perda involuntária de urina. Embora comum entre os senescentes, muitas vezes associada como parte natural do processo de envelhecimento, ela pode acometer homens e mulheres de qualquer faixa etária, e pelos mais variados motivos. Objetivo: Traçar o perfil sociodemográfico da população atendida na Unidade de Reabilitação das Disfunções do Assoalho Pélvico (UREDAPE), por queixa de IU, relacionando os principais fatores desencadeantes. Metodologia: Trata-se de uma pesquisa descritiva, transversal e retrospectiva, realizada a partir da análise de 23 prontuários dos pacientes com queixa de IU, atendidos na UREDAPE-CE, no período de janeiro de 2015 a junho de 2016. Resultados: Após a análise dos prontuários, foi possível identificar que o perfil da população atendida é caracterizado, em grande parte, por idosas, com idade entre 60 a 79 anos (65,2%), multíparas, que já passaram por alguma intervenção cirúrgica que envolvesse a musculatura do assoalho pélvico. Apesar disso, foi possível identificar também, o atendimento fisioterapêutico a pacientes adultos jovens e de meia idade, de ambos os gêneros, com fatores desencadeantes associados ou não. Considerações Finais: Diante disso, faz-se necessário o desenvolvimento de novos estudos, de amplo espectro, a fim de traçar um perfil mais detalhado dos pacientes acometidos pela IU e investigar melhor os principais fatores desencadeantes, para que seja possível o planejamento de estratégias efetivas de prevenção e tratamento desses pacientes.
Educação para Vida Adulta: por um mundo interno mais perceptivo
Authors: Quadros Alexander De , Rodrigues Claudia Flores
Published: March 2022

Neste apontamento, tencionamos propor pensar sobre a possibilidade de vislumbrar um mundo interno mais perceptivo, mais leve, capaz de anular o peso corpóreo das limitações físicas que se ganha com o processo natural de envelhecimento. Com isso, acreditamos ser possível desenvolver um espaço aberto por uma espécie de racionalidade emancipatória, agregando uma tentativa de reflexão a partir de ideias fundamentais, sejam elas: concepção de vida adulta e a importância do descobrir-se pessoa através da literatura. A partir deste texto, convidamos o leitor a fazer um exercício de “desassossego” para pensar na sua itinerância em meio ao movimentado caminho do educar-se ao longo da vida.
O Programa de Residência em Enfermagem Obstétrica do Hospital Sofia Feldman sob a perspectiva dos residentes: potencialidades e desafios
Authors: Jardim Danúbia Mariane Barbosa , Viana Juliana Xavier , Rocha Renata Lacerda Prata , Reis Gabriela Maciel dos
Published: March 2022

Objetivo: Compreender no olhar de enfermeiras residentes do programa de enfermagem obstétrica as potencialidades e desafios vivenciados no cotidiano da residência. Métodos: Trata-se de um estudo secundário, descritivo, com abordagem qualitativa. A amostra foi composta por 14 enfermeiras residentes do segundo ano do Programa de Residência em Enfermagem Obstétrica do NN. A amostra total era de 19 concluintes. A coleta dedados se deu através de entrevista gravada em áudio com roteiro semi estruturado. A análise dos dados ocorreu segundo análise de conteúdo proposta por Bardin. Obedeceu-se a Resolução nº 466/12 e obteve aprovação no Comitê de Ética. Resultados: A pesquisa apresentou resultados positivos no que diz respeito ao processo de residência na visão das enfermeiras onde foi ressaltada a importância da prática diária para efetivação do conhecimento teórico. Desafios foram apresentados tais como a dificuldade de relacionamento interpessoal principalmente com a preceptoria e a carga horária extensa de atividades. Considerações Finais: A escolha da modalidade residência para a obtenção da especialização em enfermagem obstétrica se dá principalmente pela oportunidade de vivência teórico-prática, mas essa modalidade traz desafios por sua extensa carga horária que gera sobrecarga física e psicológica, além das dificuldades de relacionamento interpessoal.
Тенденции формирования культурно-развлекательных функций при проектировании тематических парковых пространств с элементами дополненной реальности
Authors: Ачковский И.А
Published: March 2022

В статье обсуждаются вопросы создания и динамика развития тематических парков развлечений в мировой индустрии. Приведены способы проектирования парковых территорий при помощи ландшафта, дизайн-концепции, тематизации, сценария и дополненной реальности. Современная индустрия развлечений объединяет в себя различные направления культурно-досуговой деятельности с использованием современных технологий для создания атмосферы погружения при помощи AR и VR технологий. Проведено сравнение парков развлечений, находящихся в Европе и в России.
Association of MTHFR, BMP4, TGFA and IRF6 Polymorphisms with Non-Syndromic Cleft lip and Palate in North Indian Patients
Authors: Avasthi Kapil Kumar , Agarwal Amit , Agarwal Sarita
Published: March 2022

Background: Non-Syndromic Cleft Lip and Palate (NSCL/P) is a multifactorial birth defect. The world-wide prevalence of NSCL/P is 1 in 1000 live births; it differs with race, ethnicity and gender. The aim of the present study was to find out the status of candidate gene polymorphisms in NSCL/P cases and its association in phenotype of the patients.
Methods: We have screened five polymorphisms in four candidate genes MTHFR (rs1801133, rs1801131) BMP4 (rs17563), TGFA (rs1146297) and IRF6 (rs2235371) by restriction fragment length polymorphism and results were validated by Sanger sequencing. Our dataset consists of 200 NSCL/P cases and 200 healthy controls from the Indian population. Statistical data analysis was performed by SPSS software.
Results: MTHFR (rs1801133), BMP4 (rs175563) and TGFA (rs11466297) gene polymorphisms showed significant association with NSCL/P and act as a risk factor in the Indian population (p=<0.05). However, MTHFR (rs1801131), and IRF6 (rs2235371) gene polymorphisms did not show significant association with NSCL/P in the Indian population.
Conclusion: The result of the study suggests an association between MTHFR (rs1801133), BMP4 (rs175563) and TGFA (rs11466297) polymorphisms with NSCL/P in Indian population.
Coronavirus Vaccination and Mortality in the Omicron Outbreak in Iran: Mortality Reduction due to Attenuated Pathogenicity and Booster Vaccine Doses
Authors: Shamabadi Ahmad , Akhondzadeh Shahin
Published: March 2022

The article's abstract is not available.
Bioinformatic Investigation of Micro RNA-802 Target Genes, Protein Networks, and Its Potential Prognostic Value in Breast Cancer
Authors: Eini Maryam , Parsi Sepideh , Barati Mahmood , Bahramali Golnaz , Alizadeh Zarei Marziyeh , Kiani Jafar , Azarnezhad Assad , Hosseini Arshad
Published: March 2022

Background: An increasing number of studies have suggested that unveiling the molecular network of miRNAs may provide novel therapeutic targets or biomarkers. In this study, we investigated the probable molecular functions that are related to microRNA-802 (miR-802) and evaluated its prognostic value in breast cancer utilizing bioinformatics tools.
Methods: PPI network, pathway enrichment and transcription factor analysis were applied to obtain hub genes among overlapping genes of four miRNA target prediction databases. Prognosis value assessments and expression analysis of hub genes using bioinformatics tools, as well as their literature validation were performed. 
Results: Our results showed a significant correlation of the miR-802 overexpression with poor patient survival rate (BC, p=2.7e-5). We determined 247 target genes significant for GO and KEGG terms. Analysis of TFs by TRUST showed that RUNX3, FOXO3, and E2F1 are possible TFs that regulate the miR-802 expression and target genes network. According to our analysis; 21 genes might have an important function in miR-802 molecular processes and regulatory networks. The result shows that among these 21 genes, 8 genes (CASC3, ITGA4, AGO3, TARDBP, MED13L, SF1, SNRPE and CRNKL1) are positively correlated with patient survival. Therefore these genes could be considered and experimentally evaluated as a prognostic biomarker for breast cancer.
Conclusion: The comprehensive bioinformatics study on miR-802 target genes provided insight into miR-802 mediated pathways and processes. Furthermore, representing candidate target genes by prognostic values indicates the potential clinical application of miR-802 in breast cancer.
Cellular Therapy: The Hope for Covid-19
Authors: Nobari Sima , Rezvan Motahareh , Dashtestani Fariba , Gangi Mahdieh , Keshmiri Neghab Hoda
Published: March 2022

Coronaviruses (CoVs) are a group of very diverse viruses that cause a broad spectrum of diseases from mild to severe enteric, respiratory, systemic diseases, and common cold or pneumonia among humans and animals. This virus is associated with Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS), and lung disease that lead to Acute Respiratory Distress Syndrome (ARDS). In December 2019, researchers identified a novel coronavirus type, called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), which was associated with symptoms of high fever, dry cough, headache, diarrhea, and reduction of White Blood Cells (WBC). Coronavirus-associated acute respiratory disease was named Coronavirus Disease 19 (COVID-19). No proven treatment has been discovered for COVID-19 so far, but researchers are trying to find the best effective way to treat this disease. Therefore, therapeutic strategies that facilitate the recovery of COVID-19 patients and reduce life-threatening complications are urgently needed now. Today, Mesenchymal Stem Cells (MSCs) and their secretion are utilized as one of the most applied tools to treat various diseases such as inflammation and cancer. MSC-derived vesicles are rich in various growth factors, cytokines, and interleukins that are produced and secreted under different physiological or pathological conditions. These vesicles were considered a suitable and effective tool in regeneration medicine because of their high power in repairing damaged tissues and modulating immune responses. Recently, evidence has shown MSC-derived vesicles through reduced expression of pro-inflammatory cytokines could improve damaged tissues in COVID-19 patients. In addition to MSCs and MSC-derived exosomes, Natural Killer (NK) cells, T cells, and platelet lysates were used against viral infection. In this review, we tried to provide an overview of MSC secretion and immune cells for COVID-19 therapy.
Designing a Multi-Epitope Antigen for Serodiagnosis of Strongyloides stercoralis Based on L3Nie.01 and IgG Immunoreactive Epitopes
Authors: Movahedpour Ahmad , Mostafavi-Pour Zohreh , Sarkari Bahador , Taheri-Anganeh Mortaza , Nezafat Navid , Savardashtaki Amir , Ghasemi Younes
Published: March 2022

Background: Serological diagnosis of Strongyloides stercoralis  (S. stercoralis) is frequently challenging because of cross-reactivity with other parasitic nematodes. Therefore, it is necessary to introduce novel serological tests with high performance to properly diagnose this neglected parasitic infection. The purpose of the current study was to design a multi-epitope construct for the diagnosis of S. stercoralis.
Methods: For the purpose of this study, first, highly antigenic segments and potential immunodominant epitopes of S. stercoralis were identified from two antigenic proteins, and then all of the selected parts were linked by an appropriate linker. Next, the physico-chemical features of the designed construct were analyzed. Then, tertiary structures of the construct were built and evaluated to find out the best one. Lastly, the amino acid sequence was reverse-translated and optimized for over-expression in Escherchia coli (E. coli).
Results: The bioinformatic evaluation indicated that the designed protein construct could be hydrophilic, thermostable, and acidic and the estimated half-life was more than 10 hr in E. coli.
Conclusion: According to the results of the study, the designed construct could be used as an efficient antigen in the ELISA system for serological diagnosis of human strongyloidiasis.
Association of Aberrant Promoter Methylation Changes in the Suppressor of Cytokine Signaling 3 (SOCS3) Gene with Susceptibility to Crohn's Disease
Authors: Sanati Golshid , Jafari Davood , Noruzinia Mehrdad , Ebrahimi Daryani Naser , Ahmadvand Mohammad , Teimourian Shahram , Rezaei Nima
Published: March 2022

Background: Growing evidence supports that changes in the methylation state of Inflammatory Bowel Disease (IBD)-associated genes could significantly alter levels of gene expression, potentially contributing to disease onset and progression. We supposed that alterations in DNA methylation status at promoter region within the suppressor of cytokine signaling 3 (SOCS3) gene in intestinal tissues may be involved in the susceptibility to Crohn's Disease (CD).
Methods: DNA methylation status in the promoter region of the human SOCS3 gene of intestinal tissues from 15 patients with CD and 15 age- and sex-matched healthy controls were profiled using the real-time Quantitative Multiplex Methylation Specific PCR (QM-MSP) assay.
Results: Based on methylation assay data profiling, we found that patients with CD showed a higher degree of methylation of the SOCS3 gene promoter region than did the healthy controls (unmethylated DNA in CD vs. healthy controls; 0.00048±0.0011 vs. 0.07±0.142, p<0.000).
Conclusion: The data presented here demonstrate that aberrant methylation of the CpG islands within promoter regions of SOCS3 gene in colonic mucosa of CD was associated with mucosal inflammatory status, providing insights into the involvement of methylation could contribute to the initiation of the inflammatory process and development of CD.
A Motif-Based Network Analysis of Regulatory Patterns in Doxorubicin Effects on Treating Breast Cancer, a Systems Biology Study
Authors: Dehghan Zeinab , Mirmotalebisohi Seyed Amir , Sameni Marzieh , Bazgiri Maryam , Zali Hakimeh
Published: March 2022

Background: Breast cancer is the most common malignancy worldwide. Doxorubicin is an anthracycline used to treat breast cancer as the first treatment choice. Nevertheless, the molecular mechanisms underlying the response to Doxorubicin and its side effects are not comprehensively understood so far. We used systems biology and bioinformatics methods to identify essential genes and molecular mechanisms behind the body response to Doxorubicin and its side effects in breast cancer patients.
Methods: Omics data were extracted and analyzed to construct the protein-protein interaction and gene regulatory networks. Network analysis was performed to identify hubs, bottlenecks, clusters, and regulatory motifs to evaluate crucial genes and molecular mechanisms behind the body response to Doxorubicin and its side effects.
Results: Analyzing the constructed PPI and gene-TF-miRNA regulatory network showed that MCM3, MCM10, and TP53 are key hub-bottlenecks and seed proteins. Enrichment analysis also revealed cell cycle, TP53 signaling, Forkhead box O (FoxO) signaling, and viral carcinogenesis as essential pathways in response to this drug. Besides, SNARE interactions in vesicular transport and neurotrophin signaling were identified as pathways related to the side effects of Doxorubicin. The apoptosis induction, DNA repair, invasion inhibition, metastasis, and DNA replication are suggested as critical molecular mechanisms underlying Doxorubicin anti-cancer effect. SNARE interactions in vesicular transport and neurotrophin signaling and FoxO signaling pathways in glucose metabolism are probably the mechanisms responsible for side effects of Doxorubicin.
Conclusion: Following our model validation using the existing experimental data, we recommend our other newly predicted biomarkers and pathways as possible molecular mechanisms and side effects underlying the response to Doxorubicin in breast cancer requiring further investigations.
Could Frequency of Candida spp. Be Different on Various Parts of Tongue in Denture and Non-denture Wearers?
Authors: Owlia Fatemeh , Hekmatimoghaddam Seyedhossein , Kheirollahi Faraz
Published: March 2022

Background & Objectives: Oral Candidiasis is the most common opportunistic fungal infection that could affect the oral mucosa. Studies to date did not compare the colony count of candida of the anterior and posterior surfaces of the tongue. This study makes an attempt to compare the Candida spp. on the anterior and posterior surfaces of tongue among healthy denture and non-denture wearers.
Materials & Methods: Participants of the current cross-sectional study were 26 healthy denture wearers (DW) and 10 healthy non-denture wearers (NDW).  Oral specimens were collected from anterior and posterior tongue dorsa by swabbing for mycological examination. After 48 h incubation on Sabouraud dextrose agar (S) and chloramphenicol (SC) and chloramphenicol and Cycloheximide (SCC) ™ medium, C. Albicans and non-Albicans were identified by Germ Tube test. Isolated colonies were evaluated. Obtained data were analyzed by SPSS software version 17. Chi-square, Mann-Whitney and Wilcoxon tests were used for statistical comparison of data due to non-compliance with normal distribution.
Results: The higher rate of isolated colonies was seen in DW group compared to NDW group (P-Value = 0.03). There was a significant difference between candida colonization of anterior and posterior surface of tongue (P-Value = 0.006). C. Albicans was the most common isolated candida species.
Conclusions: Mycological findings of this study revealed that the presence of denture can increase colonization of candida on the posterior surface of the tongue. It could be an important role in choosing the best form for medical management of oral candidiasis.
Toxicity Effects of Lipid Nanoparticles Containing Artemisia Absinthium L Essential Oil on BRC-03 Breast Cancer Cell Line
Authors: Teimouri Maryam , Pooladi Mehdi
Published: March 2022

Background & Objective: According to research, breast cancer is the second most common cancer among women. Nanomaterials of various materials significantly increase the solubility, stability and effective drug delivery, and in recent years research on the effectiveness of essential oils and plant extracts in inhibiting the growth of cancer cells is expanding. Artemisia belongs to the Asteraceae family. In many studies, the effectiveness of the essential oil and extract of this plant in inhibiting the growth of cancer cells has been reported.
Materials & Methods: In this experiment, nanoparticles containing Artemisia absinthium L essential oil (thistle) were first synthesized by homogenizer & sonication method and then their physicochemical properties were determined, such as particle size, particle size distribution, zeta potential, percentage of loading efficiency. Then, the anti-apoptotic effect of lipid nanoparticles containing Artemisia essential oil in breast cancer cells (BRC-03) was evaluated.
Results: The results of cellular effect of lipid nanoparticles containing essential oil of Artemisia absinthium L (thistle) on breast cancer cells showed that increasing the concentration of lipid nanoparticles containing essential oil of this plant reduced the survival rate of cancer cells. Breast (BRC-03) was purified compared to essential oil (p <0.05).
Conclusion:  Nano-essential oil of this plant is effective in reducing the IC50 of the drug and in increasing the cytotoxicity of the essential oil of the plant. Lipid nanoparticles containing essential oil of Artemisia absinthium L (thistle) activated the apoptotic pathway in breast cancer cells.
The Effectiveness of Peer Group-Based Training in Adherence to Treatment of Adults with Diabetic Foot Ulcer
Authors: Mehdizade Tazangi Roya , Bijani Mostafa , Karimi Shahnaz , Naghizadeh Mohammad Mehdi , Khani Jeihooni Ali , Rahimzahedi Mohammad Hossein
Published: March 2022

Background & Objective: Adherence to treatment of patients with diabetic foot ulcer leads to successful treatment and a reduction in the severity of complications. The present study was conducted to investigate the effect of peer group-based training on adherence to treatment of adults with diabetic foot ulcers in Shiraz in 2020.
Materials & Methods: This quasi-experimental study was conducted on 70 patients (35 in the intervention group and 35 in the control group). The content of the education program was performed by the peer for the intervention group in 5 sessions of 45 minutes, and the routine education of the diabetes clinic was provided to the control group. Data collection tools included demographic characteristics questionnaire, Morisky Medication Adherence Scale (MMAS). Data were analyzed by the SPSS software version 22 using statistical tests (t-test, ANOVA and Chi-square) and the significance level was considered p<0.05.
Results: The mean score of adherence to treatment was significant immediately after the intervention, but there was no significant difference after one and three months.
Conclusion: Peer training of patients with diabetic foot ulcers could improve adherence to treatment. Therefore, health system policymakers may use this approach as an effective method in the care program of patients with diabetic foot ulcers and other diseases.
Evaluation of the Long noncoding RNA NONHSAT037832 Gene Expression Changes in Patients with Thyroid Carcinoma
Authors: Keysan Parya , Ghorbian Saeid
Published: March 2022

Background & Objective: Thyroid cancer is the most common endocrine disorder in the world. One of the main causes of this cancer is genetic changes, in particular mutations in the tumor and oncogene inhibition genes. In addition to mutations, some non-encoding RNAs called lncRNAs play an important role in the progression of tumors. NONHSAT is a lancer and has recently been referred to the role of this gene in various types of cancer. This study aimed to evaluate the lncRNA-NONHSAT037832 gene expression changes in patients with thyroid carcinoma.
Materials & Methods: A cross-sectional study was conducted on 140 homogeneous samples (70 cancer tissue homogeneous samples and 70 homogeneous healthy tissue samples) from patients with thyroid cancer referred to Alzahra Hospital in Tabriz. Using the Real-Time PCR, changes in the expression of the lncRNA-NONHSAT037832 gene were evaluated. In addition, the relationship between lncRNA-NONHSAT037832 gene expression changes and clinical parameters was investigated.
Results: The results showed that the expression of lncRNA-NONHSAT037832 gene expression in the tissues of cancer was significantly higher than healthy tissues (P <0.001) and a significant relationship with MTN (P = 0.001) and node metastasis Lymphoma was shown (P = 0.30).
Conclusion: According to the results, the lncRNA-NONHSAT037832 gene may be used as a prognostic biomarker for thyroid cancer.
The Effect of Simvastatin and Vitamin D Co-Administration on Rats Brain Function and Behavior: A Behavioral and Biochemical Study
Authors: Ranaiy Mohammad Saleh , Farokhi Farah , Babaei Balderlou Farrin
Published: March 2022

Background & Objective: The simvastatin (Sim) is a lipophilic statin and can cross the blood-brain barrier. The role of vitamin D (Vit D) in brain development and function has been supported over the past decade. This study aimed to evaluate the effect of simvastatin on memory and anxiety levels in healthy male rats.
Materials & Methods: In this experimental study, 36 male Wistar rats weighing 250-300 g were randomly divided into six groups (n=6) including control, Vit D (5 µg/kg/day; IP), Simvastatin (1 mg/kg/day; orally) (SimL), Simvastatin (10 mg/kg/day; orally) (SimH), SimL + Vit D and SimH + Vit D. After 28 days, at the end of the treatment, the behavioral anxiety test and memory behavioral test were performed. Then, the rats were euthanized, and oxidative stress markers of the brain, serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and cholesterol levels were investigated. Data were analyzed by SPSS 24 software and Tukey’s test.
Results: Co-administration of simvastatin and vitamin D significantly increased working memory, catalase activity, total antioxidant capacity, HDL-C, and decreased anxiety levels, malondialdehyde (MDA) concentration, cholesterol, and LDL-C compared to the control group (p<0.05). However, the administration of simvastatin and vitamin D alone did not significantly change the mentioned parameters compared to the control group (p>0.05).
Conclusion: Co-administration of simvastatin and vitamin D can improve brain function by reducing oxidative stress and cholesterol levels.
The Effect of Vertical Sleeve Gastrectomy on Weight Loss, Insulin and Glucose Levels in Dogs
Authors: Razavi Ebrahimi Parham , Tabatabaei Naeini Aboutorab , Raayat Jahromi Alireza , Amini Masood , Zare Afshin
Published: March 2022

Background & Objective: This study was designed to evaluate the effect of sleeve-gastrectomy procedure on weight loss, glucose and insulin blood levels in overweight dogs.
Materials & Methods: In the current study, 5 overweight dogs (31.6±3.03kg) were selected for sleeve-gastrectomy procedure. Insulin and glucose levels were measured from the blood samples that were taken before the surgery and weekly 1.5 month post-operatively. The weight of the dogs was also measured at the same time. The surgery was performed according to the technique described by Gagner 2009, and the dogs received special diet during the recovery period to end of the study.
Results: One dog died due to dehiscence and leakage 48 hours post-operatively. Decrease in mean weight was 6.25±0.44 in the first week after surgery and the weight loss process continued to end of the study. Changes in insulin and glucose blood levels demonstrated to have pulsatile patterns. Insulin levels decreased for the first week, but its level increased in the second week period. Again, insulin levels demonstrated to have decreasing pattern in the following 4 weeks. On the other hand, the glucose levels changed each week and did not show any certain pattern.
Conclusion: Post-operative weight loss was observed in all cases but it was not statistically significant. It could be due to limited number of the samples. The glucose and insulin changes were attributed to hormonal changes particularly gut hormones that were affected by sleeve-gastrectomy procedure but further detailed studies on hormonal effect are required.
Effects of Melatonin on Hepatic and Renal Complication of Diabetes
Authors: Safarzadeh Hamed , Zargari Felor
Published: March 2022

Background & Objective: Diabetes is associated with biochemical and pathological changes in liver and kidney tissue. One of the most important mechanisms in causing   complications of diabetes is increasing the production of free radicals due to impaired glucose metabolism. Some studies have shown that melatonin is effective in protecting tissues due to its antioxidant role. The aim of this study was to evaluate the effect of melatonin on biochemical factors, histopathological changes of liver and kidney in streptozotocin-induced (STZ) diabetic rats.
Materials & Methods: In this experimental study, 40 adult male rats were randomly divided into 4 groups (n=10): control group, diabetic group, melatonin group (20mg/kg BW) and melatonin + diabetic group.  At the end of the 6th week, blood samples were collected. Biomarkers of liver function (alkaline phosphatase: ALP, aspartate aminotransferase: AST, alanine aminoteransferase: ALT) and kidney biomarkers (urea, uric acid, BUN, creatinine), serum glucose and histopathological changes of these tissues were evaluated.  Data analysis was performed using SPSS and the significance level was P<0.05.
Results: Melatonin treatment significantly (P<0.05) reduced hyperglycemia, hepatic enzymes and renal biochemical factors due to diabetes and improved histopathological changes of liver and kidney tissue.
Conclusions: Melatonin consumption can be effective in improving the renal and kidney complications of diabetes.
Effect of Zinc Supplementation on some Biochemical and Hematological Parameters in Alloxan Induced Diabetic Rats
Authors: Dabirinejad Hakemeh , Dayer Mohammad Reza , Mohammadi Tayebeh
Published: March 2022

Background & Objective: This study aims to evaluate the effects of zinc sulfate on blood biochemical and hematological parameters in healthy control and alloxan-induced diabetic rats. 
Materials & Methods: Experimentally, 40 rats were used in four equal groups, including healthy control, healthy feed with zinc sulfate, diabetic control, and zinc sulfate. The alloxan 120 mg/kg with blood sugar over 140-250 mg / dL was intraperitoneally injected to induce diabetes mellitus. In addition, the value of 0.6 g / L zinc sulfate dissolved in tap water was used for three months to be drunk by the treated group. All animals were killed, and blood and pancreas samples were collected for necessary tests. Serum levels of alpha-amylase, total cholesterol, triglycerides, LDL, HDL, hemoglobin, and hematocrit were measured. Statistical data were analyzed based on the analysis of variance using SPSS software.
Results: Our data showed that in the diabetic control group, serum levels of total cholesterol, triglyceride, LDL increased significantly and hemoglobin, hematocrit, and HDL decreased significantly compared to the healthy control (P< 0.05). Zinc sulfate consumption in these groups reduces total cholesterol, triglyceride, LDL and increases hemoglobin and hematocrit compared to the control groups. Microscopic examination of the pancreas showed that in the diabetic control group, the percentage of Beta cells was reduced compared to the other groups.
Conclusion: Our findings reveal that dietary zinc sulfate not only exerts no damage to bodies but also zinc sulfate as food supplement seems to have beneficial effects on biochemical and hematological parameters in diabetic and healthy animals.
The achievement of Nursing Practice Today based on the Scopus CiteScore metrics
Authors: Beykmirza Raziyeh , Negarandeh Reza
Published: March 2022

The article's abstract is not available.
Using mobile phone applications in engaging nurses for preventing healthcare-associated infections: A systematic review
Authors: Fithriyyah Yayu Nidaul , Aulawi Khudazi
Published: March 2022

Background & Aim: Prevention of healthcare-associated infections targets health workers. Considering the crucial role of nurses, potential applications of mobile phone-based interventions are innovative, attractive, and easily accessible. This study synthesizes mobile applications with the involvement of nurses or nursing students in outcomes to prevent healthcare-associated infections  and their implications.
Methods & Materials: Systematic review, database searches included: SCOPUS, EBSCO MEDLINE, PubMed, ProQuest, Institute of Electrical and Electronics Engineers, and SagePUb. Population involved nurses or nursing students with mobile-based interventions about healthcare-associated infections. Quantitative design focused on publications between 2015-2021. Methodological quality applied the Cochrane and the National Heart, Lung, and Blood Institute tools. Analysis used narrative synthesis.
Results: 11 studies met inclusion criteria from 1,792. Study populations were heterogeneous. Mobile phone interventions included: short message service (18.2%), (9.1%), mobile and computer access (18.2%), and iOs/Android-based (27.3%). healthcare-associated infections prevention focused on: surgical site infections (54.5%), central line-associated bloodstream infections (9.1%), catheter-associated urinary tract infections (9.1%), antimicrobials (9.1%), knowledge, attitude, and practice towards healthcare-associated infections (18.2%). Most bias risks were moderate to high. Participants showed positive responses. All studies described problems in implementing healthcare-associated infections applications. Five studies reported estimated cost savings.
Conclusion: Using mobile phone applications has involved nurses as researchers, participants, and intervention providers to patients. The impact is promising in preventing healthcare-associated infections. Response of user is influenced by technology familiarity, which involves interactive features and problem anticipation. This review showed significant cost savings, so stakeholders and future research plans can consider it.
Artistic nursing care: Rodgers’ evolutionary concept analysis
Authors: Babaii Atye , Mohammadi Eesa , Sadooghiasl Afsaneh
Published: March 2022

Background & Aim: Artistic nursing care is defined as combining knowledge, skills, and judgment to provide the best care. Different studies have introduced different and even contradictory characteristics for this concept. Therefore, nurses are confused about it. This study aimed to clarify artistic nursing care.
Methods & Materials: Rodgers' evolutionary method was used to clarify the concept of artistic nursing care. This method included the initial phase, core analysis phase, and further analysis phase. Literature from 1990 to 2020 was sought using Springer, PubMed, Scopus, Web of Science, OVID, and SID databases. In general, 28 articles and two books were selected and analyzed.
Results: The attributes of artistic nursing care included discovering a unique way to establish a happy and integrated relationship with the patient, paying intuition attention to the patient individuality to recognize all their needs, creating a positive image of the patient's condition, manifesting love in caring behaviors, and creating opportunities for a healing presence. The antecedents for artistic nursing care include having knowledge and experience, commitment to ethical principles, altruism, and active presence in the field of care. Artistic nursing care improves the patient's physical and mental health, increases the patient's sense of well-being and happiness, increases patient and nurse satisfaction.
Conclusion: In this study, the antecedents, attributes, and consequences of artistic nursing care are presented objectively and practically, which can be used to teach the methods of providing artistic nursing care and design tools for measuring this concept.
Feasibility and clinical utility of the critical pain observation tool among mechanically ventilated patients
Authors: Nabeel Alshlool Khalid , Abdalrahim Maysoon , Othman Younis Wejdan
Published: March 2022

Background & Aim: The Critical Pain Observational Tool (CPOT) is one of the most valid and reliable pain assessment tools to assess pain in mechanically ventilated patients. This study aimed to investigate the Critical Care Pain Observational tool feasibility and clinical utility from the nurses’ perspective at a teaching hospital in Jordan.
Methods & Materials: Descriptive design was used to collect data from 74 nurses working in five critical care units in a teaching hospital in Jordan. The study was conducted in August 2019. The Feasibility and Clinical Utility of Critical Pain Observation Tool collected the data. Data were analyzed using SPSS software version 22.
Results: The mean feasibility score was 69.0/100 (SD=8.56) with a range of 18-33/36 (50.0-91.0/100), indicating a moderate category of feasibility. Also, the mean of the clinical utility scores was 68.53/100 (SD=9.78) with a range of 11-26/28 (39.29-92.8/100), indicating moderate clinical utility.
Conclusion: Nurses reported moderate feasibility and clinical utility of the CPOT; thus, it is important to promote education and training of nurses to ensure maximum utilization of the tool.
The effect of participating in support groups on relocation stress syndrome in residents of a nursing home: A single-blind randomized clinical trial
Authors: Hosseinzadeh Fatemeh , Ghaderi Sahar , Negarandeh Reza , Poortaghi Sarieh
Published: March 2022

Background & Aim: Relocation stress syndrome is one of the consequences of moving someone to a nursing home; it causes unbearable feelings of loneliness, anxiety, and depression. However, it can be prevented by conducting proper and timely nursing interventions. The present study aimed to examine the effect of participation in support groups on relocation stress syndrome in residents of nursing homes.
Methods & Materials: In this single-blind randomized clinical trial, 32 elderly residents of Kahrizak nursing home were randomly assigned to control and intervention groups. The intervention included holding support groups. Demographic information questionnaires, the short form of Geriatric Depression Scale (15-GDS), Geriatric Anxiety Scale (GAS), and the short form of University of California, Los Angeles, UCLA loneliness scale (ULS-8) were used to collect data. The data were then analyzed using statistical tests in SPSS software version 16.
Results: There was no statistically significant difference between the mean scores of loneliness, depression, and anxiety between the two groups in the pre-test (p> 0.05). The results of the ANCOVA test to compare the mean scores of loneliness, depression, and anxiety in the post-test with controlling pre-test scores revealed that the intervention was effective on depression (p<0.001) and anxiety (p= 0.003), but it had no effects on loneliness (p= 0.156).
Conclusion: The development and implementation of support group programs for the elderly in a nursing home could improve the outcomes of relocation stress syndrome in terms of depression and anxiety. Nonetheless, it had no effects on the outcome of loneliness. Therefore, it is recommended to implement this intervention for the elderly in a nursing home if the cost-benefit analysis is positive.
Predictors of adherence to self-care behaviors among patients with coronary heart disease
Authors: Al-Sutari Manal , Ahmad Muayyad
Published: March 2022

Background & Aim: Coronary Heart Disease (CHD) was responsible for 7.4 million deaths globally. Self-care is an integral element of standard medical management for CHD. The aims of this study were: (1) to describe self-care maintenance, self-care monitoring, self-care management, and self-care confidence among patients with CHD patients; and (2) to identify predictors of self-care maintenance, self-care monitoring, self-care management, and self-care confidence in Jordanian CHD patients.
Methods & Materials: A descriptive cross-sectional design was used. A sample of 193 patients with CHD was interviewed. Self-care behaviors were measured by the Self-Care Coronary Heart Disease Index (SC-CHDI). Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HAD), and social support was assessed using the Multidimensional Scale of Perceived Social Support (MSPSS).
Results: The mean age of the participants was 60.4 years (SD=10.61). 139 (72%) of the participants were males. Female patients were significantly worse than male patients in self-care management (P=0.045) and self-care confidence (P=0.014). Significant predictors for better self-care maintenance were older age and higher self-care confidence. The prediction model explained 17.6% of the variance in self-care maintenance (F= 4.188, P=. <001). The significant predictors for self-care confidence were self-care maintenance, self-care management, and BMI. The prediction model explained 29% of the variance in the self-care confidence (F= 7. 137, P=. <001).
Conclusion: The study revealed that self-care maintenance was adequate while self-care management and self-care confidence were suboptimal. Older age, higher educational level, and better self-care confidence were predictors of higher self-care maintenance.
Perceived control and length of stay post coronary artery bypass graft surgery
Authors: Aburuz Mohannad Eid , Dahger Nisreen , Al-Akash Hekmat Yousef , Momani Aaliyah , Refaat Ahmed Fatma
Published: March 2022

Background & Aim: Patients undergoing CABG might have increased complications postoperatively, especially prolonging post-operative Length of Stay (LOS). Perceived Control (PC) affects LOS post CABG and complications among different cardiac populations. However, this relation is not well-studied post CABG. This study aimed to determine whether PC was an independent predictor of LOS among patients post CABG.
Methods & Materials: A prospective observational design was used. A consecutive sample consisted of 220 patients from four hospitals in Amman, Jordan, who underwent elective CABG between July 2020 and January 2021. PC was assessed using the Arabic Version of the Control Attitude Scale-Revised. LOS and other necessary information were retrieved from the patients' medical records. Data were analyzed using stepwise multiple regression.
Results: 169 males and 51 females participated in this study. Age, female gender, as well as PC were found to be independent predictors for the hospital LOS. On the one hand, advanced age and female gender increased the hospital LOS, while higher levels of PC were protective. A one-year increase in age increased hospital LOS by 0.16 days, being female increased hospital LOS by 0.17 days, and a one-point increase in PC levels decreased LOS by 0.33 days. On the other hand, only female gender and PC were independent predictors for the ICU LOS. Similarly to hospital LOS, the female gender increased ICU LOS by 0.18 days while the one-point increase in PC decreased the ICU LOS by 0.21 days.
Conclusion: PC was an independent predictor that affects LOS after CABG. Increasing PC among this population, especially females and the elderly, might improve outcomes of their CABG surgery decrease hospital's LOS and the resultant morbidity.
A gestão dos impostos como momento central da distribuição justa da riqueza: o caso da Autoridade Tributária de Moçambique
Authors: Cuco Custódio João
Published: March 2022

Este artigo tenciona analisar uma questão de fundamental relevância nas sociedades contemporâneas: o pagamento dos impostos como forma de redistribuição da riqueza, com enfoque especial para a fuga ao fisco. De forma específica, o estudo debruça-se sobre a realidade de um país africano, Moçambique, em que, por um lado, as pesquisas sobre o tema são escassas, e por outro, o governo local confiou à Autoridade Tributária a tarefa de colectar os impostos dos contribuintes. Mediante uma abordagem qualitativa, de tipo histórico e sociológico, a partir da análise da actividade da Autoridade Tributária Moçambicana, o estudo conclui que o valor dos impostos arrecadado por parte da Autoridade Tributária ainda está aquém do desejado. Tal circunstância deve-se a factores estruturais, tais como escassa formação do pessoal técnico e ausência de uma base de dados fiável, assim como subjetivos, acima de tudo uma corrupção difusa entre os funcionários daquela instituição, que torna complicado o bom funcionamento da mesma, que não consegue cumprir com as suas próprias metas.
Liberdade de Imprensa em Moçambique: O caso de influência do poder politico no judiciário
Authors: Leonardo Sarmento Bacelar
Published: March 2022

O artigo foca sobre o relacionamento entre o poder político e o poder judiciário nos casos de violação da liberdade de expressão e, sobretudo a de imprensa, em Moçambique. Apesar deste garantismo e pluralismo constitucional, no ordenamento moçambicano persistem formas directas e indirectas, de limitação da liberdade de expressão e de imprensa, mesmo de cunho jurídico. Para tanto, existe uma evidente diferenciação entre a actuação do Ministério Público e dos juízes de tribunal. A  liberdade de opinião e expressão, incluindo a liberdade de “receber e difundir, sem consideração de fronteiras, informações e ideias por qualquer meio de expressão” é um dos direitos civis e políticos básicos, que se encontra formulado em todos os respectivos instrumentos de direitos humanos, quer da Declaração Universal dos Direitos Humanos de 1948 quer da Constituição da República de Moçambique. Mediante casos concretos de julgamentos feitos contra jornalistas, editores e proprietários de jornais em Moçambique, o artigo demonstra que a influência do poder político no judiciário ainda é considerável, embora nem sempre uniforme, mudando segundo o contexto (dentro ou fora de Maputo) e a situação política contingente.
O caderno escolar como artefato de pesquisa no sul do Amazonas
Authors: Santos Jusciléia Florêncio dos , Alves Maria Isabel Alonso
Published: March 2022

Este artigo é um recorte de uma dissertação produzida no âmbito do Programa de Pós-Graduação em Ensino de Ciências e Humanidades - PPGECH, da Universidade Federal do Amazonas - UFAM, cujo objetivo é mostrar um possível delineamento metodológico sobre a abordagem dos conteúdos étnico-raciais, tendo os cadernos escolares usados por alunos dos anos inicias do Ensino Fundamental como artefato empírico da pesquisa. Para a escrita deste artigo julgamos adequado utilizar a abordagem qualitativa numa perspectiva metodológica amparada em autores e autoras que abordam a análise de cadernos escolares em suas temáticas, trata-se, portanto, de uma abordagem bibliográfica, e que tem nos Estudos Culturais e Grupo Modernidade e Colonialidade sua lente teórica de investigação entre outros autores que perpassam este campo de estudo. Os resultados desta visa trazer ao contexto educacional local, e de modo geral em nossa sociedade reflexões, e ações a respeito da aplicabilidade da Lei Nº 11.645/2008 com relação a educação das relações étnico-raciais. As reflexões aqui postas apontam que o caderno escolar pode ser um importante material empírico de pesquisa sobre as questões étnico-raciais no Sul do Amazonas, especificamente na rede municipal de ensino de Humaitá.
Mortality in the populations of Danzig and the District of Danzig (“Regierungsbezirk Danzig”) in the second half of the nineteenth century
Authors: Budnik Alicja , Liczbińska Grażyna
Published: March 2022

The study concerning the populations of: the city of Danzig, Kartuzy County and the whole District of Danzig (Regierungsbezirk Danzig) has been based on demographic data from German yearbooks published in the second half of the nineteenth century and at the beginning of the twentieth century. The research has covered the period between 1855 and 1879 for the city of Danzig and between 1860 and 1869 for the District of Danzig. For selected years some demographic measures, such as: death rates, infant death rates, natural increase, and population dynamics rates have been estimated. At the same time, seasonal fluctuations in mortality within a year and the most important cultural and biological causes for death have been disscussed. Moreover, life tables for the whole District of Danzig have been built. (The authors employed two methods: firstly - Hailey’s proposal, assuming at first a stationary type of population and then a model stable in regard to formerly calculated natural increase; secondly - a technique based on probability of death). Finally, the opportunity for natural selection through differential mortality has been estimated (Crow index Im, potential gross reproduction rate Rp«, biological state index lb,). The results of the own research have been compared to attainable data concerning other regions of Poland under partition.
A review of anthropological approaches to ageing
Authors: Kaczmarek Maria , Szwed Anita
Published: March 2022

It is evident that the pattern of ageing among humans has a unique character. Therefore, when undertaking any research on human ageing one has to specify a proper methodology and methods which are available in the anthropological perspective. The paper is aimed at providing a review of anthropological approaches to the study of ageing. On the basis of the meaning and scope of the concept of ageing, its sources and causal factors are discussed. Further, functional, physiological and morphological indicators of ageing are briefly described. Much attention is focused on the concept of biological age which is the key notion for assessment of variation in the rates of human ageing.