bluuebunny/crossref_metadata_2025 huggingface dataset:
Zanubrutinib-induced aseptic meningitis: a case report and literature review
Authors: Yang Jinjun , Wang Lian , Zhong Xiao , Yang Chenlu , Wu Yu
Published: August 2023

Zanubrutinib is a Bruton tyrosine kinase (BTK) inhibitor used in B cell malignancy treatment and is generally well tolerated in most patients. Zanubrutinib-induced aseptic meningitis is currently not reported. Herein, we present the first case of zanubrutinib-induced aseptic meningitis. A 33-year-old woman was diagnosed with relapsed/refractory follicular lymphoma and subsequently developed aseptic meningitis after receiving zanubrutinib treatment. We reviewed the literature and uncovered the lack of current reports on zanubrutinib or other BTK inhibitor-induced aseptic meningitis. Moreover, we summarized cases on aseptic meningitis induced by common chemotherapy and targeted drugs used for hematological diseases. Drug-induced aseptic meningitis (DIAM) is a drug-induced meningeal inflammation. The possible pathogenesis is the direct stimulation of the meninges via intrathecal injection of chemotherapy drugs and immune hypersensitivity response caused by immunosuppressive drugs. It is more common in women with immune deficiency and mainly manifests as persistent headache and fever. Cerebrospinal fluid examinations mainly demonstrate a significant increase in cells and proteins. DIAM diagnosis needs to exclude bacterial, fungal, viral, and tuberculosis infections; neoplastic meningitis; and systemic diseases involving the meninges. The prognosis of DIAM is usually favorable, and physicians should detect and stop the causative drug. In conclusion, zanubrutinib-induced aseptic meningitis is a rare but serious complication, and physicians should be promptly aware of this adverse event to avoid serious consequences.
Unleashing the efficacy of immune checkpoint inhibitors for advanced hepatocellular carcinoma: factors, strategies, and ongoing trials
Authors: Yu Jiahui , Li Mengnan , Ren Boxu , Cheng Le , Wang Xiaoxiao , Ma Zhaowu , Yong Wei Peng , Chen Xiaoguang , Wang Lingzhi , Goh Boon Cher
Published: August 2023

Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer, representing approximately 85% of cases. The diagnosis is often made in the middle and late stages, necessitating systemic treatment as the primary therapeutic option. Despite sorafenib being the established standard of care for advanced HCC in the past decade, the efficacy of systemic therapy remains unsatisfactory, highlighting the need for novel treatment modalities. Recent breakthroughs in immunotherapy have shown promise in HCC treatment, particularly with immune checkpoint inhibitors (ICIs). However, the response rate to ICIs is currently limited to approximately 15%–20% of HCC patients. Recently, ICIs demonstrated greater efficacy in “hot" tumors, highlighting the urgency to devise more effective approaches to transform “cold" tumors into “hot" tumors, thereby enhancing the therapeutic potential of ICIs. This review presented an updated summary of the factors influencing the effectiveness of immunotherapy in HCC treatment, identified potential combination therapies that may improve patient response rates to ICIs, and offered an overview of ongoing clinical trials focusing on ICI-based combination therapy.
Nrf2 and autonomic dysregulation in chronic heart failure and hypertension
Authors: Wafi Ahmed M.
Published: August 2023

Redox imbalance plays essential role in the pathogenesis of cardiovascular diseases. Chronic heart failure (CHF) and hypertension are associated with central oxidative stress, which is partly mediated by the downregulation of antioxidant enzymes in the central autonomic neurons that regulate sympathetic outflow, resulting in sympathoexcitation. Antioxidant proteins are partially regulated by the transcriptional factor nuclear factor erythroid 2-related factor 2 (Nrf2). Downregulation of Nrf2 is key to disrupting central redox homeostasis and mediating sympathetic nerve activity in the setting of Chronic heart failure and hypertension. Nrf2, in turn, is regulated by various mechanisms, such as extracellular vesicle-enriched microRNAs derived from several cell types, including heart and skeletal muscle. In this review, we discuss the role of Nrf2 in regulating oxidative stress in the brain and its impact on sympathoexcitation in Chronic heart failure and hypertension. Importantly, we also discuss interorgan communication via extracellular vesicle pathways that mediate central redox imbalance through Nrf2 signaling.
Calcitonin gene-related peptide protects from soluble fms-like tyrosine kinase-1-induced vascular dysfunction in a preeclampsia mouse model
Authors: Mishra Akansha , Betancourt Ancizar , Vidyadharan Vipin Alukkal , Blesson Chellakkan Selvanesan , Belfort Michael , Yallampalli Chandra , Chauhan Madhu
Published: August 2023

Introduction: Preeclampsia (PE) is a hypertensive disorder during pregnancy associated with elevated levels of soluble FMS-like tyrosine kinase (sFLT-1) and increased vascular sensitivity to angiotensin II (ATII). Calcitonin gene-related peptide (CALCA) is a potent vasodilator that inhibits the ATII-induced increase in blood pressure and protects against ATII-induced increases in oxidative stress through a mitochondrial-dependent pathway in male mice. In rodent pregnancy, CALCA facilitates pregnancy-induced vascular adaptation. Most of the vascular effects of CALCA are mediated by vascular smooth muscle cells (VSMCs). We recently reported that CALCA treatment inhibits sFLT-1-induced decreases in cAMP synthesis in omental artery smooth muscle cells (OASMCs) isolated from pregnant women and has relaxant effects in omental arteries (OAs) isolated from pregnant women with preeclamptic (PE) pregnancies. The current study was designed to assess the effects of sFLT-1 on mitochondrial bioenergetics in OASMCs isolated from pregnant women in the presence or absence of CALCA and assess the development of vascular dysfunction in sFLT-1 using a mouse model of PE pregnancy.

Methods: OASMCs were isolated from pregnant women to assess the effects of sFLT-1 on mitochondrial bioenergetics and oxidative stress using the Seahorse assay and quantitative PCR. Pregnant mice overexpressing sFLT-1 via adenoviral delivery were used to assess the effects of CALCA infusion on the sFLT-1-induced increase in blood pressure, ATII hypersensitivity, fetal growth restriction, and the elevated albumin–creatinine ratio. Systemic blood pressure was recorded in conscious, freely moving mice using implantable radio telemetry devices.

Results: CALCA inhibited the following sFLT-1-induced effects: 1) increased oxidative stress and the decreased oxygen consumption rate (OCR) in response to maximal respiration and ATP synthesis; 2) increases in the expression of mitochondrial enzyme complexes in OASMCs; 3) increased mitochondrial fragmentation in OASMCs; 4) decreased expression of mitophagy-associated PINK1 and DRAM1 mRNA expression in OASMCs; and 5) increased blood pressure, ATII hypersensitivity, fetal growth restriction, and the albumin–creatinine ratio in sFLT-1-overexpressing pregnant mice.

Conclusion: CALCA inhibits sFLT-1-induced alterations in mitochondrial bioenergetics in vascular smooth muscle cells and development of maternal vascular dysfunction in a mouse model of PE.
The hypoxia-inducible factor 1 pathway plays a critical role in the development of breast muscle myopathies in broiler chickens: a comprehensive review
Authors: Alnahhas Nabeel , Pouliot Eric , Saucier Linda
Published: August 2023

In light of the increased worldwide demand for poultry meat, genetic selection efforts have intensified to produce broiler strains that grow at a higher rate, have greater breast meat yield (BMY), and convert feed to meat more efficiently. The increased selection pressure for these traits, BMY in particular, has produced multiple breast meat quality defects collectively known as breast muscle myopathies (BMM). Hypoxia has been proposed as one of the major mechanisms triggering the onset and occurrence of these myopathies. In this review, the relevant literature on the causes and consequences of hypoxia in broiler breast muscles is reviewed and discussed, with a special focus on the hypoxia-inducible factor 1 (HIF-1) pathway. Muscle fiber hypertrophy induced by selective breeding for greater BMY reduces the space available in the perimysium and endomysium for blood vessels and capillaries. The hypoxic state that results from the lack of circulation in muscle tissue activates the HIF-1 pathway. This pathway alters energy metabolism by promoting anaerobic glycolysis, suppressing the tricarboxylic acid cycle and damaging mitochondrial function. These changes lead to oxidative stress that further exacerbate the progression of BMM. In addition, activating the HIF-1 pathway promotes fatty acid synthesis, lipogenesis, and lipid accumulation in myopathic muscle tissue, and interacts with profibrotic growth factors leading to increased deposition of matrix proteins in muscle tissue. By promoting lipidosis and fibrosis, the HIF-1 pathway contributes to the development of the distinctive phenotypes of BMM, including white striations in white striping–affected muscles and the increased hardness of wooden breast–affected muscles.
Comparative transcriptional and co-expression network analysis of two upland cotton accessions with extreme phenotypic differences reveals molecular mechanisms of fiber development
Authors: He Jiasen , Xu Zhongyang , Azhar Muhammad Tehseen , Zhang Zhen , Li Pengtao , Gong Juwu , Jiang Xiao , Fan Senmiao , Ge Qun , Yuan Youlu , Shang Haihong
Published: August 2023

Introduction

Upland cotton (Gossypium hirsutum) is the main source of natural fiber in the global textile industry, and thus its fiber quality and yield are important parameters. In this study, comparative transcriptomics was used to analyze differentially expressed genes (DEGs) due to its ability to effectively screen candidate genes during the developmental stages of cotton fiber. However, research using this method is limited, particularly on fiber development. The aim of this study was to uncover the molecular mechanisms underlying the whole period of fiber development and the differences in transcriptional levels.

Methods

Comparative transcriptomes are used to analyze transcriptome data and to screen for differentially expressed genes. STEM and WGCNA were used to screen for key genes involved in fiber development. qRT-PCR was performed to verify gene expression of selected DEGs and hub genes.

Results

Two accessions of upland cotton with extreme phenotypic differences, namely EZ60 and ZR014121, were used to carry out RNA sequencing (RNA-seq) on fiber samples from different fiber development stages. The results identified 704, 376, 141, 269, 761, and 586 genes that were upregulated, and 1,052, 476, 355, 259, 702, and 847 genes that were downregulated at 0, 5, 10, 15, 20, and 25 days post anthesis, respectively. Similar expression patterns of DEGs were monitored using short time-series expression miner (STEM) analysis, and associated pathways of DEGs within profiles were investigated. In addition, weighted gene co-expression network analysis (WGCNA) identified five key modules in fiber development and screened 20 hub genes involved in the development of fibers.

Discussion

Through the annotation of the genes, it was found that the excessive expression of resistance-related genes in the early fiber development stages affects the fiber yield, whereas the sustained expression of cell elongation-related genes is critical for long fibers. This study provides new information that can be used to improve fibers in newly developed upland cotton genotypes.
Favorable physiological and morphological effects of molybdenum nanoparticles on tobacco (Nicotiana tabacum L.): root irrigation is superior to foliar spraying
Authors: Chen Juanni , Yin Ying , Zhu Yunsong , Song Kun , Ding Wei
Published: August 2023

Introduction

Nano fertilizers can provide efficient solutions to the increasing problem of nutrient deficiency caused by low availability. However, the most important prerequisite is to fully understand whether nanomaterials induce phytotoxicity in plants under a variety of different conditions. The mechanisms underlying interactions between molybdenum nanoparticles (Mo NPs) and plants with respect to their uptake and biological effects on crops are still not fully understood.

Methods

In this study, the impacts of Mo NPs over a range of concentrations (0, 25, and 100 μg/mL) on tobacco (Nicotiana tabacum L.) seedling growth were comparatively evaluated under foliar applications and root irrigation.

Results

The results indicated that more significant active biological effects were observed with root irrigation application of Mo NPs than with foliar spraying. The agronomic attributes, water content and sugar content of Mo NPs-exposed seedlings were positively affected, and morphologically, Mo NPs induced root cell lignification and more vascular bundles and vessels in tobacco tissues, especially when applied by means of root irrigation. Moreover, the photosynthetic rate was improved by 131.4% for root exposure to 100 μg/mL Mo NPs, mainly due to the increased chlorophyll content and stomatal conductance. A significant concentration-dependent increase in malonaldehyde (MDA) and defensive enzyme activity for the Mo NPs-treated tobacco seedlings were detected compared to the controls. Significantly improved absorption of Mo by exposed tobacco seedlings was confirmed with inductively coupled plasma mass spectrometry (ICP-MS) in tobacco tissues, regardless of application method. However, the accumulation of Mo in roots increased by 13.94 times, when roots were exposed to 100 mg/L Mo NPs, higher than that under treatment with foliar spray. Additionally, Mo NPs activated the expression of several genes related to photosynthesis and aquaporin processes.

Discussion

The present investigations offer a better understanding of Mo NPs-plant interactions in terrestrial ecosystems and provide a new strategy for the application of Mo NPs as nano fertilizers in crop production.
Phosphorus and naphthalene acetic acid increased the seed yield by regulating carbon and nitrogen assimilation of flax
Authors: Xie Yaping , Duan Huirong , Wang Limin , Zhang Jianping , Dong Kongjun , Wang Xingrong , Zhang Yanjun , Zhou Yangchen , Li Wenjuan , Qi Yanni , Zhao Wei , Dang Zhao , Wang Xingzhen , Li Wen , Zhao Lirong
Published: August 2023

To evaluate the impact of phosphorus (P) combined with exogenous NAA on flax yield, enhance flax P utilization efficiency and productivity, minimize resource inputs and mitigate negative environmental and human effects. Therefore, it is crucial to comprehend the physiological and biochemical responses of flax to P and naphthylacetic acid (NAA) in order to guide future agronomic management strategies for increasing seed yield. A randomized complete block design trial was conducted under semi-arid conditions in Northwest China, using a factorial split-plot to investigate the effects of three P (0, 67.5, and 135.0 kg P2O5 ha–1) and three exogenous spray NAA levels (0, 20, and 40 mg NAA L–1) on sucrose phosphate synthase (SPS) and diphosphoribulose carboxylase (Rubisco) activities as well as nitrogen (N) and P accumulation and translocation in flax. Results indicated that the SPS and Rubisco activities, N and P accumulation at flowering and maturity along with assimilation and translocation post-flowering, fruiting branches per plant, tillers per plant, capsules per plant, and seed yield were 95, 105, 14, 27, 55, 15, 13, 110, 103, 82, 16, 61, 8, and 13% greater in the P treatments compared to those in the zero P treatment, respectively. Moreover, those characteristics were observed to be greater with exogenous spray NAA treatments compared to that no spray NAA treatment. Additionally, the maximum SPS and Rubisco activities, N and P accumulation, assimilation post-flowering and translocation, capsules per plant, and seed yield were achieved with the application of 67.5 kg P2O5 ha–1 with 20 mg NAA L–1. Therefore, these findings demonstrate that the appropriate combination of P fertilizer and spray NAA is an effective agronomic management strategy for regulating carbon and nitrogen assimilation by maintaining photosynthetic efficiency in plants to increase flax productivity.
Vitis labrusca genome assembly reveals diversification between wild and cultivated grapevine genomes
Authors: Li Bo , Gschwend Andrea R.
Published: August 2023

Wild grapevines are important genetic resources in breeding programs to confer adaptive fitness traits and unique fruit characteristics, but the genetics underlying these traits, and their evolutionary origins, are largely unknown. To determine the factors that contributed to grapevine genome diversification, we performed comprehensive intragenomic and intergenomic analyses with three cultivated European (including the PN40024 reference genome) and two wild North American grapevine genomes, including our newly released Vitis labrusca genome. We found the heterozygosity of the cultivated grapevine genomes was twice as high as the wild grapevine genomes studied. Approximately 30% of V. labrusca and 48% of V. vinifera Chardonnay genes were heterozygous or hemizygous and a considerable number of collinear genes between Chardonnay and V. labrusca had different gene zygosity. Our study revealed evidence that supports gene gain-loss events in parental genomes resulted in the inheritance of hemizygous genes in the Chardonnay genome. Thousands of segmental duplications supplied source material for genome-specific genes, further driving diversification of the genomes studied. We found an enrichment of recently duplicated, adaptive genes in similar functional pathways, but differential retention of environment-specific adaptive genes within each genome. For example, large expansions of NLR genes were discovered in the two wild grapevine genomes studied. Our findings support variation in transposable elements contributed to unique traits in grapevines. Our work revealed gene zygosity, segmental duplications, gene gain-and-loss variations, and transposable element polymorphisms can be key driving forces for grapevine genome diversification.
Women’s career motivation: social barriers and enablers in Sudan
Authors: Mohamed Souad , Abbashar Aida , Abushama Hala
Published: August 2023

Introduction

This study presents an original contribution by examining an often-neglected country in the Middle East and Northeast Africa (MENA), with a specific focus on women’s career research. It identifies challenges that have created barriers for Sudanese women’s career progression, consequently limiting their opportunities for career and leadership growth. To conceptualize understand women’s career motivations on a global and regional scale, the study conducted an in-depth review and analysis of literature, benchmarked similar countries, and incorporated psychological and organizational behavior theories, alongside examples of women’s empowerment cases from the MENA region.

Methods

The study employs a multifaceted approach that involves exploring psychological and organizational theories, drawing insights from self-efficacy, stereotype, and implicit bias theories, as well as MENA empowerment cases. Additionally, an empirical investigation is conducted through an extensive three-round Delphi study involving 75 Sudanese women leaders from diverse sectors. The empirical findings are crucial for understanding obstacles faced by women and the impact of Sudan’s unique social context on their career paths.

Results

The research findings shed light on the complex interplay of factors creating roadblocks for Sudanese women’s career advancement. Sudan’s distinctive social context significantly shapes and influences women’s career motivations in diverse and interconnected ways. Empirical evidence from the Delphi study underscores the broad impact of these roadblocks, highlighting the multiplicity of challenges faced by women in Sudan. This comprehensive analysis not only aids in comprehending workplace obstacles but also provides valuable insights into the diverse experiences and needs of female employees. The findings emphasize the broad impact of these barriers on women, underscoring their varied challenges.

Discussion

The research holds far-reaching implications. By contextually identifying barriers that impede Sudanese women’s career motivations, the study lays a foundation for targeted solutions. This understanding is grounded in historical, theoretical, and policy-making perspectives, enabling informed strategies to support women’s advancement. The study also offers actionable policy recommendations for governments, workplaces, and stakeholders, facilitating women’s career growth through policy reforms and capacity-building initiatives. Furthermore, its significance extends beyond Sudan, acting as a catalyst for developing gender-responsive policies in similar MENA countries and beyond.
Exploring the acoustic and prosodic features of a lung-function-sensitive repeated-word speech articulation test
Authors: Zeng Biao , Williams Edgar Mark , Owen Chelsea , Zhang Cong , Davies Shakiela Khanam , Evans Keira , Preudhomme Savannah-Rose
Published: August 2023

Introduction

Speech breathing is a term usually used to refer to the manner in which expired air and lung mechanics are utilized for the production of the airflow necessary for phonation. Neurologically, speech breathing overrides the normal rhythms of alveolar ventilation. Speech breathing is generated using the diaphragm, glottis, and tongue. The glottis is the opening between the vocal folds in the larynx; it is the primary valve between the lungs and the mouth, and by varying its degree of opening, the sound can be varied. The use of voice as an indicator of health has been widely reported. Chronic obstructive pulmonary disease (COPD) is the most common long-term respiratory disease. The main symptoms of COPD are increasing breathlessness, a persistent chesty cough with phlegm, frequent chest infections, and persistent wheezing. There is no cure for COPD, and it is one of the leading causes of death worldwide. The principal cause of COPD is tobacco smoking, and estimates indicate that COPD will become the third leading cause of death worldwide by 2030. The long-term aim of this research program is to understand how speech generation, breathing, and lung function are linked in people with chronic respiratory diseases such as COPD.

Methods

This pilot study was designed to test an articulatory speech task that uses a single word (“helicopter”), repeated multiple times, to challenge speech-generated breathing and breathlessness. Specifically, a single-word articulation task was used to challenge respiratory system endurance in people with healthy lungs by asking participants to rapidly repeat the word “helicopter” for three 20-s runs interspersed with two 20-s rest periods of silent relaxed breathing. Acoustic and prosodic features were then extracted from the audio recordings of each adult participant.

Results and discussion

The pause ratio increased from the first run to the third, representing an increasing demand for breath. These data show that the repeated articulation task challenges speech articulation in a quantifiable manner, which may prove useful in defining respiratory ill-health.
The influence of sport motivation on college students’ subjective exercise experience: a mediation model with moderation
Authors: Liu Fengbo , Li Ning
Published: August 2023

Background

The degree to which an individual experiences a positive emotional state after exercise is a measurement of how much enjoyment sports bring to the individual. This can also be seen as the individual’s essential motivation for engaging in sports, and an indirect means of improving the individual’s physical health. Therefore, it is necessary to explore the factors that affect college students’ subjective exercise experience and their effecting mechanism, thereby providing a basis for promoting college students’ positive emotional experience after exercise.

Methods

A questionnaire survey on 600 college students was conducted to examine the mediating effect of sport-confidence on the relationship between college students’ sport motivation and their subjective exercise experience, and to investigate whether this process is moderated by the feelings of inadequacy.

Results

The indirect effect of sport-confidence was significant (95% CI [0.133, 0.276]), and the index of moderated mediation Bootstrap 95% CI [0.003, 0.017] did not contain 0.

Conclusion

The results indicated that: (1) sport-confidence had a partial mediating effect between college students’ sport motivation and their subjective exercise experience; (2) the mediating effect of sport-confidence was moderated by the feelings of inadequacy, and the feelings of inadequacy moderated the latter half path of the mediating process of sport motivation - sport-confidence - subjective exercise experience. Therefore, the influence of college students’ sport motivation on their subjective exercise experience is a moderated mediating model.
Long-term exercise training and inflammatory biomarkers in healthy subjects: a meta-analysis of randomized controlled trials
Authors: Wang Ya-Hai , Tan Jingwang , Zhou Huan-Huan , Cao Meng , Zou Yu
Published: August 2023

Objective

This meta-analysis investigated the effect of long-term exercise training (ET) including aerobic, resistance, and multicomponent ET on the levels of inflammatory biomarkers in randomized controlled trials (RCTs) involving healthy subjects.

Methods

We searched seven databases for articles until May 1st, 2023. A random-effect meta-analysis, subgroup analysis, meta-regressions as well as trim and fill method were conducted using STATA 16.0.

Result

Thirty-eight studies were included in the meta-analysis, involving 2,557 healthy subjects (mean age varies from 21 to 86 years). Long-term ET induced significantly decreased in the levels of interleukin-6 (IL-6) (SMD -0.16, 95% CI -0.30 to −0.03, p = 0.017), C-reactive protein (CRP) (SMD -0.18, 95% CI -0.31 to −0.06, p = 0.005), as well as tumor necrosis factor alpha (TNFα) (SMD -0.43, 95% CI -0.62 to −0.24, p < 0.001). Subgroup analysis revealed that Long-term ET conducted for more than 12 weeks and exercise of moderate intensity had greater anti-inflammatory effects. Meta-regression analysis showed that the reduction in CRP level induced by long-term ET was weakened by increasing exercise intensity.

Conclusion

Long-term ET induced significant anti-inflammatory effects in healthy subjects. Long-term ET-induced anti-inflammatory effects were associated with exercise of moderate intensity and training conducted for more than 12 weeks.

Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/# myprospero, PROSPERO, identifier CRD42022346693.
Evaluation of the correlation between depression and physical activity among older persons with osteoporosis: a cross-sectional study
Authors: Shi Linjun , Zhou Xiaoping , Gao Yueshan , Li Xia , Fang Ronghua , Deng Xuexue
Published: August 2023

Background

Osteoporosis is a common chronic disease in older persons. Physical activity can prevent chronic diseases as well as many diseases associated with aging. Older persons often suffer from depression and other psychological problems. However, there are few studies on the correlation between depression and physical activity in older persons with osteoporosis in China.

Methods

This cross-sectional study was conducted from June 1 to December 28, 2021. A total of 207 subjects who met the inclusion and were exclusion criteria were selected from the outpatient department of West China Hospital and evaluated using a self-designed demographic data questionnaire, the Self-rating Depression Scale (SDS), and the Physical Activity Scale for the Elderly (PASE). Multivariate linear regression was performed to analyze the factors affecting physical activity, and multivariate logistic regression analysis was performed to analyze the factors affecting depression. Spearman’s correlation coefficients were calculated to analyze the correlation between depression and physical activity in older persons with osteoporosis.

Results

A total of 173 valid questionnaires were statistically analyzed. A total of 122 (70.5%) participants were identified as having depression (SDS ≥ 50 points). The median depression score was 62.5 (24.38), and the median PASE score was 69.29 (116.64). Multivariate logistic regression model results showed that physical activity and pain were the main risk factors for depression in older persons with osteoporosis (p < 0.05). Multivariate linear regression model results showed that gender, participation in social activities, activities of daily living status (ADLs), and depression status were the main risk factors associated with physical activity in older persons with osteoporosis (p < 0.05). The results of the correlation analysis showed that physical activity was negatively correlated with depression (R = −0.510, p = 0.000).

Conclusion

We found that depression was negatively correlated with physical activity in older persons with osteoporosis in China. This means that the less physical activity there is, the more serious the depression status and having depression may result in reduced physical activity in older persons with osteoporosis. To better help older persons with osteoporosis, medical staff should give more attention to influencing factors of depression and physical activity.
Executive function deficits and medial temporal lobe atrophy in late-life depression and Alzheimer’s disease: a comparative study
Authors: Chu Changbiao , Pan Weigang , Ren Yanping , Mao Peixian , Yang Chunlin , Liu Chaomeng , Tang Yi-lang
Published: August 2023

Objectives

Alzheimer’s disease (AD) and late-life depression (LLD) frequently exhibit executive function deficits (EFD) and medial temporal lobe atrophy (MTA) as shared characteristics. The objective of this research was to examine the utility of the Trail Making Test (TMT) and the MTA scale in distinguishing between LLD and AD.

Methods

A study of 100 patients, 50 with AD and 50 with LLD, was conducted using a cross-sectional design. The individuals were subjected to clinical evaluations to assess their level of depression and overall cognitive abilities, which included the Geriatric Depression Scale (GDS), Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). We evaluated executive function deficits (EFD) through the use of the TMT, which includes both TMT-A and TMT-B. MTA was measured using magnetic resonance imaging. To evaluate the ability of TMT and MTA scale to distinguish between the two groups, a receiver operating characteristic (ROC) curve was utilized. To investigate the connections between MTA and neuropsychological measures, a correlation analysis was performed.

Results

AD patients exhibited notably reduced MMSE, MoCA, and GDS scores, as well as an increased MTA total scores, time spent on TMT-A, and TMT-B compared to LLD patients (p < 0.05). TMT-A and TMT-B both exhibited excellent discriminatory power between AD and LLD, achieving area under curve (AUC) values of 92.2 and 94.2%, respectively. In AD patients, there was a negative correlation between MMSE and MoCA scores and MTA scores, while in LLD patients, there was a positive correlation between time spent on TMT-A and GDS scores and MTA scores.

Conclusion

AD patients experience more severe EFD and MTA than LLD patients. The differential diagnosis of AD and LLD can be aided by the useful tool known as TMT. It is important to acknowledge that TMT is capable of capturing only a fraction of the executive function, thus necessitating a cautious interpretation of research findings.
Depression and death anxiety among patients undergoing hemodialysis during the COVID-19 pandemic in Palestine: a cross sectional study
Authors: Ibrahim Mohammed , Saeed Elias , Hamarsheh Islam , Al Zabadi Hamzeh , Ahmead Muna
Published: August 2023

Background

Hemodialysis patients are vulnerable to serious complications such as prolonged hospital stay and psychosocial issues like depression and death anxiety. Studies on psychosocial factors on end-stage renal disease patients’ outcomes during COVID-19 pandemic are limited. We aimed to determine the prevalence of depression and death anxiety among Palestinian hemodialysis patients and the evaluate the relationship between their sociodemographic and clinical characteristics during COVID-19 Pandemic.

Methods

A cross-sectional study was conducted using a convenience sampling technique. We recruited 308 hemodialysis patients from five hemodialysis units located in government hospitals in Palestine. Beck Depression Inventory and the Templers Death Anxiety Scale were used to collect data, which were then analyzed using SPSS version 20. Descriptive statistics (frequencies and means), t-test, ANOVA and multiple linear regression models were used for data analysis.

Results

Nearly 66.2% of the sample had depression symptoms, 61.4% met the diagnostic threshold for depression, and 69.8% had death anxiety. Furthermore, the multivariate analysis revealed that having a female identity, residing in a city or refugee camp, and patients who reported not experiencing depression had a significant relationship with death anxiety, while having a higher educational level than 12 years, having one or more chronic co-morbidities, and patients who reported experiencing death anxiety had a significant correlation with depression.

Conclusion

Patients receiving hemodialysis frequently experience depression and death anxiety. These patients should receive a psychiatric evaluation in the early stages of their illness so that timely and appropriate psychological interventions can be given in hemodialysis facilities in Palestine during and after future pandemics.
Occupational survey-based evidence of health status and welfare problems of workers with pneumoconiosis in China
Authors: Hu Wenxiu , Wu Wei-Ning , Qiao Qingmei
Published: August 2023

Background

Pneumoconiosis is the most dangerous occupational disease in China. According to unofficial records, nearly million migrant workers were affected by pneumoconiosis in 2011, with the number increasing annually. Among them, a large number of migrant workers suffering from pneumoconiosis were not medically diagnosed. Therefore, fundamental questions remain unanswered: what is the background of workers who receive a diagnosis of pneumoconiosis, and how does pneumoconiosis affect their future and well-being?

Methods

In this study, we identified and surveyed 1,134 workers with pneumoconiosis in seven selected regions in China with substantially high incidences of pneumoconiosis by using a combination of cluster sampling, convenience sampling, and snowball sampling. We used demographic, medical, and rehabilitation conditions and welfare questionnaires to collect the data.

Results

The findings highlighted the socioeconomic status of patients with pneumoconiosis. The majority of workers with pneumoconiosis were adult men who had received no higher education, who lived in rural households, and who were employed in mining or manufacturing industries. Among these workers, 52.8% had been exposed to dust at work for more than 10 years, and 53.1% received a diagnosis of stage II or III pneumoconiosis. More than half of the workers (569 workers, 50.2%) did not receive comprehensive, routine treatment; 33.4% (379 workers) visited a doctor when they experienced physical discomfort, and 6.6% (75 workers) never received treatment. Only 156 workers (13.8%) received rehabilitation services, whereas 978 workers (86.2%) never did. The study results also revealed the severe financial difficulties faced by patients with pneumoconiosis. Only 208 workers (18.3%) had access to work-related injury insurance, with the cost of pneumoconiosis treatment being a substantial burden for 668 workers (60.6%).

Conclusion

In this study, we explored the existing health and welfare problems faced by workers with pneumoconiosis in China and identified the social injustice and health disparities that these workers experience. We also clarified the primary challenges in implementing safety, health, and welfare policies for these workers and those who are exposed to high-risk environments, such as those working in mining.
International practices in health technology assessment and public financing of digital health technologies: recommendations for Hungary
Authors: Mezei Fruzsina , Horváth Krisztián , Pálfi Máté , Lovas Kornélia , Ádám Ildikó , Túri Gergő
Published: August 2023

Background

Evaluating and integrating digital health technologies is a critical component of a national healthcare ecosystem in the 2020s and is expected to even increase in significance.

Design

The paper gives an overview of international practices on public financing and health technology assessment of digital health technologies (DHTs) in five European Union (EU) countries and outlines recommendations for country-level action that relevant stakeholders can consider in order to support uptake of digital health solutions in Hungary. A scoping review was carried out to identify and gather country-specific classifications and international practices on the financing DHTs in five pioneering EU countries: Germany, France, Belgium, the United Kingdom and Finland.

Results

Several frameworks have been developed for DHTs, however there is no single, unified framework or method for classification, evaluation, and financing of digital health technologies in European context. European countries apply different taxonomy, use different assessment domains and regulations for the reimbursement of DHTs. The Working Group of the Hungarian Health Economic Society recommends eight specific points for stakeholders, importantly taking active role in shaping common clinical evidence standards and technical quality criteria across in order for common standards to be developed in the European Union single market.

Conclusion

Specificities of national healthcare contexts must be taken into account in decisions to allocate public funds to certain therapies rather than others.
Molecular markers associated with drug resistance in Plasmodium falciparum parasites in central Africa between 2016 and 2021
Authors: Xu Wenjie , Zhang Xuan , Chen Hualiang , Zhang Jiaqi , Lu Qiaoyi , Ruan Wei , Wang Xiaoxiao
Published: August 2023

Objectives

The widespread occurrence of anti-malarial drug resistance threatens the current efforts to control malaria in African regions. Molecular marker surveillance helps to track the emergence and spread of drug-resistant malaria cases.

Methods

A total of 237 Plasmodium falciparum infections imported from central Africa to Zhejiang Province, China, between 2016 and 2021, were investigated. Genomic DNA was extracted from blood samples of each patient and nested PCRs was used to detect molecular markers in k13, Pfcrt, and Pfmdr1 genes. The spatial and temporal distributions of the molecular markers were analyzed.

Results

A limited polymorphism of k13 was observed, including two nonsynonymous (D464E and K503E) and five synonymous mutations. Wild-type CVMNK of Pfcrt predominated (78.5%), whereas 19.5% of the samples harbored the mutant haplotype, CVIET. The point mutation Y184F and the single mutant haplotype NF of Pfmdr1 were the most frequently observed. The geographical distributions of the Pfcrt and Pfmdr1 haplotypes displayed distinct patterns, with the mutant haplotype of Pfcrt more common in Gabon (53.9%) and Congo (50.0%), and wild haplotypes of Pfmdr1 more frequently found in Cameroon, Angola, and Congo. The prevalence of wild-type CVMNK of Pfcrt increased from 68.5–74.6% in 2016–2017 to 81.8–87.5% in 2018–2021. The proportion of wild-type Pfmdr1 also increased from 27.1% in 2016 to 38.5% in 2019.

Conclusion

The geographical and temporal distribution of k13, Pfcrt, and Pfmdr1 polymorphisms in P. falciparum parasites imported from central Africa between 2016 and 2021 are demonstrated. Our data provide updated evidence that can be used to adjust anti-malarial drug policies in central Africa and China.
Autistic individuals show less grouping-induced bias in numerosity judgments
Authors: Pomè Antonella , Karaminis Themis , Burr David C.
Published: August 2023

Introduction

When items are connected together, they tend to be perceived as an integrated whole rather than as individual dots, causing a strong underestimation of the numerosity of the ensemble. Previous evidence on grouping-induced biases of numerosity has shown a dependency on autistic-like personality traits in neurotypical adults, with a weaker tendency for grouping into meaningful segmented objects in individuals with strong autistic traits. Here we asked whether this result would generalize to the autistic population.

Methods

Twenty-two adults with a diagnosis of Autism Spectrum Disorder (ASD) and 22 matched neurotypical controls judged the numerosity of clouds of dot-pairs connected by thin lines.

Results

Results showed no significant group difference in discrimination precision, suggesting that both groups were equally capable performing the task. However, while connecting pairs of dots at moderate numerosities caused large changes in apparent numerosity in the neurotypical controls, particularly those with low autistic-like traits, it had little effect in the group of autistic participants, suggesting significant differences in numerosity estimation between autistic and neurotypical perception. Consistent with earlier studies, the magnitude of the effect covaried strongly with AQ-defined autistic traits in the neurotypical range, reinforcing the idea that autistic traits predict the strength of grouping.

Discussion

These results provide strong support for the theories of autistic perception that highlight dissimilarities in global vs. local processing, and open the door to study grouping mechanisms indirectly, by asking participants to report on the apparent numerosity rather than on the grouping organization per se.
Dimensions of cognitive reserve and their predictive power of cognitive performance and decline in the elderly
Authors: del Ser Teodoro , Valeriano-Lorenzo Elizabeth , Jáñez-Escalada Luis , Ávila-Villanueva Marina , Frades Belén , Zea María-Ascensión , Valentí Meritxell , Zhang Linda , Fernández-Blázquez Miguel A.
Published: August 2023

Background

The relative importance of different components of cognitive reserve (CR), as well as their differences by gender, are poorly established.

Objective

To explore several dimensions of CR, their differences by gender, and their effects on cognitive performance and trajectory in a cohort of older people without relevant psychiatric, neurologic, or systemic conditions.

Methods

Twenty-one variables related to the education, occupation, social activities, and life habits of 1,093 home-dwelling and cognitively healthy individuals, between 68 and 86 years old, were explored using factorial analyses to delineate several dimensions of CR. These dimensions were contrasted with baseline cognitive performance, follow-up over 5 years of participants' cognitive trajectory, conversion to mild cognitive impairment (MCI), and brain volumes using regression and growth curve models, controlling for gender, age, marital status, number of medications, trait anxiety, depression, and ApoE genotype.

Results

Five highly intercorrelated dimensions of CR were identified, with some differences in their structure and effects based on gender. Three of them, education/occupation, midlife cognitive activities, and leisure activities, were significantly associated with late-life cognitive performance, accounting for more than 20% of its variance. The education/occupation had positive effect on the rate of cognitive decline during the 5-year follow up in individuals with final diagnosis of MCI but showed a reduced risk for MCI in men. None of these dimensions showed significant relationships with gray or white matter volumes.

Conclusion

Proxy markers of CR can be represented by five interrelated dimensions. Education/occupation, midlife cognitive activities, and leisure activities are associated with better cognitive performance in old age and provide a buffer against cognitive impairment. Education/occupation may delay the clinical onset of MCI and is also associated with the rate of change in cognitive performance.
Oral microbiome as a co-mediator of halitosis and periodontitis: a narrative review
Authors: Lee Yeon-Hee , Hong Ji-Youn
Published: August 2023

Objective

Halitosis or oral malodor is an unpleasant odor from the oral cavity. However, although patients with periodontitis often complain of halitosis, their relationship has not been fully elucidated. We reviewed previous literature based on the hypothesis that the relationship between halitosis and periodontitis is mediated by the oral microbiome.

Materials and methods

This narrative review sought to provide insight into the causative role of the oral microbiome in influencing halitosis and periodontitis. In addition, we tried to deepen knowledge related to the relationship between halitosis and periodontitis generated by the oral microbiome accumulated over the past 40 years.

Results

From 1984 to 2023, a total of 106 papers that carefully and scientifically dealt with halitosis and periodontitis were included in this narrative review. Based on previous results, halitosis and periodontitis were closely related. For decades, researchers have taken an intriguing approach to the question of whether there is a relationship between halitosis and periodontitis. Central factors in the relationship between halitosis and periodontitis include volatile sulfur compounds (VSCs), the oral microbiota that produce VSCs, and the inflammatory response.

Conclusions

Taken together, the more severe periodontitis, the higher the level of VSC in halitosis, which may be mediated by oral microbiome. However, the relationship between the occurrence, maintenance, and exacerbation of periodontitis and halitosis is not a necessary and sufficient condition for each other because they are complex interplay even in one individual.
Knowledge, attitude, and practice of pesticide use by vegetable growers in Bangladesh: a health literacy perspective in relation to non-communicable diseases
Authors: Shahidullah A. K. M. , Islam Anisul , Rahman Mokhlesur
Published: August 2023

Pesticides are widely used by vegetable growers in Bangladesh, however the health consequences of these chemicals in relation to non-communicable diseases (NCDs) is largely unknown. NCDs have emerged as a major health concern in recent decades and cause deaths, chronic illnesses, and psychosomatic suffering for people worldwide. In Bangladesh, a lack of health literacy among other reasons contributes to the occurrence and prevalence of NCDs. This study interprets and evaluates the status of key health literacy forming components, such as knowledge, attitude, and practices (KAP) of vegetable growers with respect to the use of pesticides. The study was carried out in six districts of Bangladesh. A multistage sampling procedure was used to obtain a survey sample of 334 farmers who grow vegetables and use pesticides. The results revealed that the level of knowledge of the farmers is poor. They are also not very aware of the relationship between pesticide use and potential vulnerability to NCDs. Such knowledge, along with attitude and practices developed through long-held beliefs and perceptions are not helpful for the safe and appropriate use and application of pesticides. To redress such KAP situations among vegetable growers, we posit that policy actors and stakeholders across public health and agricultural sectors, and developmental agencies must strive to improve health literacy in terms of KAP. Large-scale programmatic interventions in the knowledge, attitude, and practices of vegetable growers through training, education, or mass promotion could enhance their literacy and diminish the unabated use of pesticides.