bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanistic Investigation on ROS Resistance of Phosphorothioated DNA
Authors: Wu Tingting , Huang Qiang , Wang Xiao-Lei , Shi Ting , Bai Linquan , Liang Jingdan , Wang Zhijun , Deng Zixin , Zhao Yi-Lei
Published: February 2017

Phosphorothioated DNA (PT-DNA) exhibits a mild anti-oxidant property both in vivo and in vitro. It was found that 8-OHdG and ROS levels were significantly lower in dnd+ (i.e. S+) E. coli., compared to a dnd− (i.e. S−) strain. Furthermore, different from traditional antioxidants, phosphorothioate compound presents an unexpectedly high capacity to quench hydroxyl radical. Oxidative product analysis by liquid chromatography-mass spectrometry and quantum mechanistic computation supported its unique anti-oxidant characteristic of the hydroxyl selectivity: phosphorothioate donates an electron to either hydroxyl radical or guanine radical derived from hydroxyl radical, leading to a PS• radical; a complex of PS• radical and OH− (i.e. the reductive product of hydroxyl radical) releases a highly reductive HS• radical, which scavenges more equivalents of oxidants in the way to high-covalent sulphur compounds such as sulphur, sulphite and sulphate. The PS-PO conversion (PS and PO denote phosphorus-sulphur and phosphorus-oxygen compounds, respectively) made a switch of extremely oxidative OH• to highly reductive HS• species, endowing PT-DNA with the observed high capacity in hydroxyl-radical neutralization. This plausible mechanism provides partial rationale as to why bacteria develop the resource-demanding PT modification on guanine-neighboring phosphates in genome.
DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway
Authors: Du Cheng , Li Dan-qi , Li Na , Chen Li , Li Shi-sen , Yang Yang , Hou Ming-xiao , Xie Man-jiang , Zheng Zhen-dong
Published: February 2017

DEAD (Asp-Glu-Ala-Asp) box helicase 5 (DDX5) is an ATP-dependent RNA helicase that is overexpressed in various malignancies. Increasing evidence suggests that DDX5 participates in carcinogenesis and cancer progression via promoting cell proliferation and metastasis. However, the functional role of DDX5 in gastric cancer is largely unknown. In this study, we observed that DDX5 was significantly up-regulated in gastric cancer tissues compared with the paired adjacent normal tissues. The expression of DDX5 correlated strongly with Ki67 index and pathological stage of gastric cancer. In vitro and in vivo studies suggested that knockdown of DDX5 inhibited gastric cancer cell proliferation, colony formation and xenografts growth, whereas ectopic expression of DDX5 promoted these cellular functions. Mechanically, DDX5 induced gastric cancer cell growth by activating mTOR/S6K1. Treatment of everolimus, the specific mTOR inhibitor, significantly attenuated DDX5-mediated cell proliferation. Interestingly, the expression of DDX5 and p-mTOR in gastric cancer tissues demonstrated a positive correlation. Taken together, these results revealed a novel role of DDX5 in gastric cancer cell proliferation via the mTOR pathway. Therefore, DDX5 may serve as a therapeutic target in gastric cancer.
A novel HRM assay for the simultaneous detection and differentiation of eight poxviruses of medical and veterinary importance
Authors: Gelaye Esayas , Mach Lukas , Kolodziejek Jolanta , Grabherr Reingard , Loitsch Angelika , Achenbach Jenna E. , Nowotny Norbert , Diallo Adama , Lamien Charles Euloge
Published: February 2017

Poxviruses belonging to the Orthopoxvirus, Capripoxvirus and Parapoxvirus genera share common host species and create a challenge for diagnosis. Here, we developed a novel multiplex PCR method for the simultaneous detection and differentiation of eight poxviruses, belonging to three genera: cowpox virus (CPXV) and camelpox virus (CMLV) [genus Orthopoxvirus]; goatpox virus (GTPV), sheeppox virus (SPPV) and lumpy skin disease virus (LSDV) [genus Capripoxvirus]; orf virus (ORFV), pseudocowpox virus (PCPV) and bovine papular stomatitis virus (BPSV) [genus Parapoxvirus]. The assay is based on high-resolution melting curve analysis (HRMCA) of PCR amplicons produced using genus specific primer pairs and dsDNA binding dye. Differences in fragment size and GC content were used as discriminating power. The assay generated three well separated melting regions for each genus and provided additional intra-genus genotyping allowing the differentiation of the eight poxviruses based on amplicon melting temperature. Out of 271 poxviral DNA samples tested: seven CPXV, 25 CMLV, 42 GTPV, 20 SPPV, 120 LSDV, 33 ORFV, 20 PCPV and two BPSV were detected; two samples presented co-infection with CMLV and PCPV. The assay provides a rapid, sensitive, specific and cost-effective method for the detection of pox diseases in a broad range of animal species and humans.
Transformation from slip to plastic flow deformation mechanism during tensile deformation of zirconium nanocontacts
Authors: Yamada Kohei , Kizuka Tokushi
Published: February 2017

Various types of nanometer-sized structures have been applied to advanced functional and structural devices. Inherent structures, thermal stability, and properties of such nanostructures are emphasized when their size is decreased to several nanometers, especially, to several atoms. In this study, we observed the atomistic tensile deformation process of zirconium nanocontacts, which are typical nanostructures used in connection of nanometer-sized wires, transistors, and diodes, memory devices, and sensors, by in situ transmission electron microscopy. It was found that the contact was deformed via a plastic flow mechanism, which differs from the slip on lattice planes frequently observed in metals, and that the crystallinity became disordered. The various irregular relaxed structures formed during the deformation process affected the conductance.
Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A
Authors: Ren Peijun , Zheng Yimei , Wang Wenqi , Hong Liping , Delpeyroux Françis , Arenzana-Seisdedos Fernando , Altmeyer Ralf
Published: February 2017

Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. Here, we identify VP1-145 as the critical amino acid that accounts for the differential sensitivity of EVA-71 viruses to suramin. A single Q or G to E substitution at VP1-145 results in an approximately 30-fold shift of IC50 or IC90 values reproducing the inhibition profile observed with field isolates expressing either the 145Q or E mutation. Our data support the conclusion that suramin binds to the positively charged region surrounding the 5-fold axis of the capsid and consequently blocks the virus attachment and entry into host cells. In order to assess the antiviral-spectrum of suramin, we analyzed 18 representative enteroviruses: A (n = 7), B (n = 5), C (n = 5) and D (n = 1). We show that suramin potency is restricted to enterovirus A species. Clinical development of suramin is further supported by pharmacokinetic data demonstrating bioactive plasma levels after a single dose intramuscular administration in macaques. Altogether, our findings support the clinical development of suramin as a novel entry inhibitor for the treatment of enterovirus A infections.
Laser Calorimetry Spectroscopy for ppm-level Dissolved Gas Detection and Analysis
Authors: K. S. Nagapriya , Sinha Shashank , R. Prashanth , Poonacha Samhitha , Chaudhry Gunaranjan , Bhattacharya Anandaroop , Choudhury Niloy , Mahalik Saroj , Maity Sandip
Published: February 2017

In this paper we report a newly developed technique – laser calorimetry spectroscopy (LCS), which is a combination of laser absorption spectroscopy and calorimetry - for the detection of gases dissolved in liquids. The technique involves determination of concentration of a dissolved gas by irradiating the liquid with light of a wavelength where the gas absorbs, and measuring the temperature change caused by the absorbance. Conventionally, detection of dissolved gases with sufficient sensitivity and specificity was done by first extracting the gases from the liquid and then analyzing the gases using techniques such as gas chromatography. Using LCS, we have been able to detect ppm levels of dissolved gases without extracting them from the liquid. In this paper, we show the detection of dissolved acetylene in transformer oil in the mid infrared (MIR) wavelength (3021 nm) region.
Interaction of Cutibacterium ( formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development
Authors: Aubin Guillaume Ghislain , Baud’huin Marc , Lavigne Jean-Philippe , Brion Régis , Gouin François , Lepelletier Didier , Jacqueline Cédric , Heymann Dominique , Asehnoune Karim , Corvec Stéphane
Published: February 2017

Cutibacterium acnes (formerly Propionibacterium acnes) is recognized as a pathogen in foreign-body infections (arthroplasty or spinal instrumentation). To date, the direct impact of C. acnes on bone cells has never been explored. The clade of 11 C. acnes clinical isolates was determined by MLST. Human osteoblasts and osteoclasts were infected by live C. acnes. The whole genome sequence of six isolates of this collection was analyzed. CC36 C. acnes strains were significantly less internalized by osteoblasts and osteoclasts than CC18 and CC28 C. acnes strains (p ≤ 0.05). The CC18 C. acnes ATCC6919 isolate could survive intracellularly for at least 96 hours. C. acnes significantly decreased the resorption ability of osteoclasts with a major impact by the CC36 strain (p ≤ 0.05). Genome analysis revealed 27 genes possibly linked to these phenotypic behaviors. We showed a direct impact of C. acnes on bone cells, providing new explanations about the development of C. acnes foreign-body infections.
Super-hydrophobic Silver-Doped TiO2 @ Polycarbonate Coatings Created on Various Material Substrates with Visible-Light Photocatalysis for Self-Cleaning Contaminant Degradation
Authors: Li Zhengjian , Sun Zongzhao , Duan Zhiqiang , Li Rui , Yang Yanli , Wang Jingyi , Lv Xiaoxia , Qi Wei , Wang Hua
Published: February 2017

In the present work, a facile and efficient fabrication method has been developed for creating super-hydrophobic coatings of silver-doped TiO2@polycarbonate (TiO2 (Ag)@PC) on the substrates of different materials with photocatalytic self-cleaning performances simply by the “dipping and drying” process. The substrates were first patterned with glue and then deposited with the dopamine-capped TiO2 (Ag)@PC (DA-TiO2 (Ag)@PC) nanocomposites, followed by the further etching with dimethylbenzene. The so prepared super-hydrophobic E-DA-TiO2(Ag)@PC coatings could present the lotus leaf-like porous architectures, high adhesion stability, and especially the visible-light photocatalysis for organic contaminant degradation, thus promising the wide outdoor and indoor applications like water proofing, metal erosion protection, and surface self-cleaning.
S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice
Authors: Guilloux Jean-Philippe , Samuels Benjamin A. , Mendez-David Indira , Hu Alice , Levinstein Marjorie , Faye Charlène , Mekiri Maryam , Mocaer Elisabeth , Gardier Alain M. , Hen René , Sors Aurore , David Denis J.
Published: February 2017

Strategies designed to increase adult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments. H3 receptor antagonists/inverse agonists also may be useful for treating cognitive deficits. However, it remains unclear whether these ligands have effects on AHN. The present study aimed to investigate the effects of a 28-day treatment with S 38093, a novel brain-penetrant antagonist/inverse agonist of H3 receptors, on AHN (proliferation, maturation and survival) in 3-month-old and in aged 16-month-old mice. In addition, the effects of S 38093 treatment on 7-month-old APPSWE Tg2576 transgenic mice, a model of Alzheimer’s disease, were also assessed. In all tested models, chronic treatment with S 38093 stimulated all steps of AHN. In aged animals, S 38093 induced a reversal of age-dependent effects on hippocampal brain-derived neurotrophic factor (BDNF) BDNF-IX, BDNF-IV and BDNF-I transcripts and increased vascular endothelial growth factor (VEGF) expression. Finally, the effects of chronic administration of S 38093 were assessed on a neurogenesis-dependent “context discrimination (CS) test” in aged mice. While ageing altered mouse CS, chronic S 38093 treatment significantly improved CS. Taken together, these results provide evidence that chronic S 38093 treatment increases adult hippocampal neurogenesis and may provide an innovative strategy to improve age-associated cognitive deficits.
Magma plumbing system and seismicity of an active mid-ocean ridge volcano
Authors: Schmid Florian , Schlindwein Vera , Koulakov Ivan , Plötz Aline , Scholz John-Robert
Published: February 2017

At mid-ocean ridges volcanism generally decreases with spreading rate but surprisingly massive volcanic centres occur at the slowest spreading ridges. These volcanoes can host unexpectedly strong earthquakes and vigorous, explosive submarine eruptions. Our understanding of the geodynamic processes forming these volcanic centres is still incomplete due to a lack of geophysical data and the difficulty to capture their rare phases of magmatic activity. We present a local earthquake tomographic image of the magma plumbing system beneath the Segment 8 volcano at the ultraslow-spreading Southwest Indian Ridge. The tomography shows a confined domain of partial melt under the volcano. We infer that from there melt is horizontally transported to a neighbouring ridge segment at 35 km distance where microearthquake swarms and intrusion tremor occur that suggest ongoing magmatic activity. Teleseismic earthquakes around the Segment 8 volcano, prior to our study, indicate that the current magmatic spreading episode may already have lasted over a decade and hence its temporal extent greatly exceeds the frequent short-lived spreading episodes at faster opening mid-ocean ridges.
Cuttlebone-like V2O5 Nanofibre Scaffolds – Advances in Structuring Cellular Solids
Authors: Knöller Andrea , Runčevski Tomče , Dinnebier Robert E. , Bill Joachim , Burghard Zaklina
Published: February 2017

The synthesis of ceramic materials combining high porosity and permeability with good mechanical stability is challenging, as optimising the latter requires compromises regarding the first two properties. Nonetheless, significant progress can be made in this direction by taking advantage of the structural design principles evolved by nature. Natural cellular solids achieve good mechanical stability via a defined hierarchical organisation of the building blocks they are composed of. Here, we report the first synthetic, ceramic-based scaffold whose architecture closely mimics that of cuttlebone –a structural biomaterial whose porosity exceeds that of most other natural cellular solids, whilst preserving an excellent mechanical strength. The nanostructured, single-component scaffold, obtained by ice-templated assembly of V2O5 nanofibres, features a highly sophisticated and elaborate architecture of equally spaced lamellas, which are regularly connected by pillars as lamella support. It displays an unprecedented porosity of 99.8 %, complemented by an enhanced mechanical stability. This novel bioinspired, functional material not only displays mechanical characteristics similar to natural cuttlebone, but the multifunctionality of the V2O5 nanofibres also renders possible applications, including catalysts, sensors and electrodes for energy storage.
Pneumococcal prophages are diverse, but not without structure or history
Authors: Brueggemann Angela B. , Harrold Caroline L. , Rezaei Javan Reza , van Tonder Andries J. , McDonnell Angus J. , Edwards Ben A.
Published: February 2017

Bacteriophages (phages) infect many bacterial species, but little is known about the diversity of phages among the pneumococcus, a leading global pathogen. The objectives of this study were to determine the prevalence, diversity and molecular epidemiology of prophages (phage DNA integrated within the bacterial genome) among pneumococci isolated over the past 90 years. Nearly 500 pneumococcal genomes were investigated and RNA sequencing was used to explore prophage gene expression. We revealed that every pneumococcal genome contained prophage DNA. 286 full-length/putatively full-length pneumococcal prophages were identified, of which 163 have not previously been reported. Full-length prophages clustered into four major groups and every group dated from the 1930–40 s onward. There was limited evidence for genes shared between prophage clusters. Prophages typically integrated in one of five different sites within the pneumococcal genome. 72% of prophages possessed the virulence genes pblA and/or pblB. Individual prophages and the host pneumococcal genetic lineage were strongly associated and some prophages persisted for many decades. RNA sequencing provided clear evidence of prophage gene expression. Overall, pneumococcal prophages were highly prevalent, demonstrated a structured population, possessed genes associated with virulence, and were expressed under experimental conditions. Pneumococcal prophages are likely to play a more important role in pneumococcal biology and evolution than previously recognised.
Switching of a large anomalous Hall effect between metamagnetic phases of a non-collinear antiferromagnet
Authors: Sürgers Christoph , Wolf Thomas , Adelmann Peter , Kittler Wolfram , Fischer Gerda , Löhneysen Hilbert v.
Published: February 2017

The anomalous Hall effect (AHE), which in long-range ordered ferromagnets appears as a voltage transverse to the current and usually is proportional to the magnetization, often is believed to be of negligible size in antiferromagnets due to their low uniform magnetization. However, recent experiments and theory have demonstrated that certain antiferromagnets with a non-collinear arrangement of magnetic moments exhibit a sizeable spontaneous AHE at zero field due to a non-vanishing Berry curvature arising from the quantum mechanical phase of the electron’s wave functions. Here we show that antiferromagnetic Mn5Si3 single crystals exibit a large AHE which is strongly anisotropic and shows multiple transitions with sign changes at different magnetic fields due to field-induced rearrangements of the magnetic structure despite only tiny variations of the total magnetization. The presence of multiple non-collinear magnetic phases offers the unique possiblity to explore the details of the AHE and the sensitivity of the Hall effect on the details of the magnetic texture.
Role of relativity in high-pressure phase transitions of thallium
Authors: Kotmool Komsilp , Chakraborty Sudip , Bovornratanaraks Thiti , Ahuja Rajeev
Published: February 2017

We demonstrate the relativistic effects in high-pressure phase transitions of heavy element thallium. The known first phase transition from h.c.p. to f.c.c. is initially investigated by various relativistic levels and exchange-correlation functionals as implemented in FPLO method, as well as scalar relativistic scheme within PAW formalism. The electronic structure calculations are interpreted from the perspective of energetic stability and electronic density of states. The full relativistic scheme (FR) within L(S)DA performs to be the scheme that resembles mostly with experimental results with a transition pressure of 3 GPa. The s-p hybridization and the valence-core overlapping of 6s and 5d states are the primary reasons behind the f.c.c. phase occurrence. A recent proposed phase, i.e., a body-centered tetragonal (b.c.t.) phase, is confirmed with a small distortion from the f.c.c. phase. We have also predicted a reversible b.c.t. → f.c.c. phase transition at 800 GPa. This finding has been suggested that almost all the III-A elements (Ga, In and Tl) exhibit the b.c.t. → f.c.c. phase transition at extremely high pressure.
Genome-wide primary transcriptome analysis of H2-producing archaeon Thermococcus onnurineus NA1
Authors: Cho Suhyung , Kim Min-Sik , Jeong Yujin , Lee Bo-Rahm , Lee Jung-Hyun , Kang Sung Gyun , Cho Byung-Kwan
Published: February 2017

In spite of their pivotal roles in transcriptional and post-transcriptional processes, the regulatory elements of archaeal genomes are not yet fully understood. Here, we determine the primary transcriptome of the H2-producing archaeon Thermococcus onnurineus NA1. We identified 1,082 purine-rich transcription initiation sites along with well-conserved TATA box, A-rich B recognition element (BRE), and promoter proximal element (PPE) motif in promoter regions, a high pyrimidine nucleotide content (T/C) at the −1 position, and Shine-Dalgarno (SD) motifs (GGDGRD) in 5′ untranslated regions (5′ UTRs). Along with differential transcript levels, 117 leaderless genes and 86 non-coding RNAs (ncRNAs) were identified, representing diverse cellular functions and potential regulatory functions under the different growth conditions. Interestingly, we observed low GC content in ncRNAs for RNA-based regulation via unstructured forms or interaction with other cellular components. Further comparative analysis of T. onnurineus upstream regulatory sequences with those of closely related archaeal genomes demonstrated that transcription of orthologous genes are initiated by highly conserved promoter sequences, however their upstream sequences for transcriptional and translational regulation are largely diverse. These results provide the genetic information of T. onnurineus for its future application in metabolic engineering.
The importance of pollen chemistry in evolutionary host shifts of bees
Authors: Vanderplanck Maryse , Vereecken Nicolas J. , Grumiau Laurent , Esposito Fabiana , Lognay Georges , Wattiez Ruddy , Michez Denis
Published: February 2017

Although bee-plant associations are generally maintained through speciation processes, host shifts have occurred during evolution. Understanding shifts between both phylogenetically and morphologically unrelated plants (i.e., host-saltation) is especially important since they could have been key processes in the origin and radiation of bees. Probably far from being a random process, such host-saltation might be driven by hidden constraints associated with plant traits. We selected two clades of oligolectic bees (i.e., Colletes succinctus group and Melitta leporina group) foraging on co-flowering but unrelated host-plants to test this hypothesis. We analyzed floral scent, floral color and chemical composition of pollen from host and non-host plants of these two clades. We did not find evidence for host-plant evolution in the Melitta leporina group driven by one of the assayed floral traits. On the contrary, hosts of the C. succinctus group display similar primary nutritive content of pollen (i.e., amino acids and sterols) but not similar floral scent or color, suggesting that shared pollen chemistry probably mediates saltation in this clade. Our study revealed that constraints shaping floral associations are diverse and clearly depend on species life-history traits, but evidence suggests that pollen chemistry may act as a major floral filter and guide evolutionary host-shifts.
Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9
Authors: Lv Ji-Neng , Zhou Gao-Hui , Chen Xuejiao , Chen Hui , Wu Kun-Chao , Xiang Lue , Lei Xin-Lan , Zhang Xiao , Wu Rong-Han , Jin Zi-Bing
Published: February 2017

Precursor messenger RNA (Pre-mRNA) splicing is an essential biological process in eukaryotic cells. Genetic mutations in many spliceosome genes confer human eye diseases. Mutations in the pre-mRNA splicing factor, RP9 (also known as PAP1), predispose autosomal dominant retinitis pigmentosa (adRP) with an early onset and severe vision loss. However, underlying molecular mechanisms of the RP9 mutation causing photoreceptor degeneration remains fully unknown. Here, we utilize the CRISPR/Cas9 system to generate both the Rp9 gene knockout (KO) and point mutation knock in (KI) (Rp9, c.A386T, P.H129L) which is analogous to the reported one in the retinitis pigmentosa patients (RP9, c.A410T, P.H137L) in 661 W retinal photoreceptor cells in vitro. We found that proliferation and migration were significantly decreased in the mutated cells. Gene expression profiling by RNA-Seq demonstrated that RP associated genes, Fscn2 and Bbs2, were down-regulated in the mutated cells. Furthermore, pre-mRNA splicing of the Fscn2 gene was markedly affected. Our findings reveal a functional relationship between the ubiquitously expressing RP9 and the disease-specific gene, thereafter provide a new insight of disease mechanism in RP9-related retinitis pigmentosa.
Elliptical polarization of near-resonant linearly polarized probe light in optically pumped alkali metal vapor
Authors: Li Yingying , Wang Zhiguo , Jin Shilong , Yuan Jie , Luo Hui
Published: February 2017

Optically pumped alkali metal atoms currently provide a sensitive solution for magnetic microscopic measurements. As the most practicable plan, Faraday rotation of linearly polarized light is extensively used in spin polarization measurements of alkali metal atoms. In some cases, near-resonant Faraday rotation is applied to improve the sensitivity. However, the near-resonant linearly polarized probe light is elliptically polarized after passing through optically pumped alkali metal vapor. The ellipticity of transmitted near-resonant probe light is numerically calculated and experimentally measured. In addition, we also analyze the negative impact of elliptical polarization on Faraday rotation measurements. From our theoretical estimate and experimental results, the elliptical polarization forms an inevitable error in spin polarization measurements.
Highly stable chemisorption of dyes with pyridyl anchors over TiO2: application in dye-sensitized photoelectrochemical water reduction in aqueous media
Authors: Takijiri Kohei , Morita Kohei , Nakazono Takashi , Sakai Ken , Ozawa Hironobu
Published: February 2017

The “pyridyl anchoring technique” enables constant photocurrent density in a water reduction dye-sensitized photoelectrochemical cell with a polypyridyl ruthenium sensitizer having pyridyl anchors (Ru-py).
Theoretical study of HCN–water interaction: five dimensional potential energy surfaces
Authors: Sánchez Ernesto Quintas , Dubernet Marie-Lise
Published: February 2017

A new five-dimensional potential energy surface is calculated at the coupled-cluster CCSD(T) level of theory for the HCN–water system, treating both monomers as rigid rotors. The associated methodology, provides a time-saving approach to compute quantitatively accurate potential energy surfaces with reasonable computational effort.
Cation/macromolecule interaction in alkaline cellulose solution characterized with pulsed field-gradient spin-echo NMR spectroscopy
Authors: Wang Sen , Sun Peng , Zhang Rongrong , Lu Ang , Liu Maili , Zhang Lina
Published: February 2017

Using an alternative to the traditional method of 1H diffusometry, the interaction of cations with the cellulose macromolecule is investigated with facileness, accuracy and precision.
Temperature dependence of ion diffusion coefficients in NaCl electrolyte confined within graphene nanochannels
Authors: Kong Jing , Bo Zheng , Yang Huachao , Yang Jinyuan , Shuai Xiaorui , Yan Jianhua , Cen Kefa
Published: February 2017

The ion diffusion coefficients of NaCl electrolyte confined within graphene nanochannels at different temperatures are investigated using molecular dynamics simulations.
Transdermal cellular membrane penetration of proteins with gold nanoparticles: a molecular dynamics study
Authors: Gupta Rakesh , Kashyap Nishi , Rai Beena
Published: February 2017

We present the molecular mechanism of co-delivery of a model protein through the skin using gold nanoparticles. This could help in designing nanoparticles for both transdermal drug delivery and cosmetic applications.
H-Bonding controls the emission properties of functionalized carbon nano-dots
Authors: Mukherjee Soumalya , Prasad Edamana , Chadha Anju
Published: February 2017

The role of H-bonds in controlling the photoluminescence from N-CDs is investigated and the results indicate that both the Lippert–Mataga model and Kamlet–Taft parameters are required to satisfactorily explain the photophysical properties of dispersed N-CDs.
Metal borohydrides and derivatives – synthesis, structure and properties
Authors: Paskevicius Mark , Jepsen Lars H. , Schouwink Pascal , Černý Radovan , Ravnsbæk Dorthe B. , Filinchuk Yaroslav , Dornheim Martin , Besenbacher Flemming , Jensen Torben R.
Published: February 2017

A comprehensive review of metal borohydrides from synthesis to application.
Pt quantum dots deposited on N-doped (BiO)2CO3: enhanced visible light photocatalytic NO removal and reaction pathway
Authors: Dong Xing'an , Zhang Wendong , Cui Wen , Sun Yanjuan , Huang Hongwei , Wu Zhongbiao , Dong Fan
Published: February 2017

The reaction pathway for visible light photocatalytic NO removal with Pt quantum dots/N-doped (BiO)2CO3was revealed within situFT-IR and ESR spectroscopy.
Hydrogenation/oxidation triggered highly efficient reversible color switching of organic molecules
Authors: Zhou Xiao , Jiang Yi-Fan , Guo Hong-Li , Wang Xin , Liu Ya-Nan , Imran M. , Xu An-Wu
Published: February 2017

The reversible hydrogenation/oxidative dehydrogenation process of TH+/LTH over a highly active Pd–ZnO1−x hybrid catalyst under ambient conditions.
POM@IL-MOFs – inclusion of POMs in ionic liquid modified MOFs to produce recyclable oxidation catalysts
Authors: Abednatanzi Sara , Leus Karen , Derakhshandeh Parviz Gohari , Nahra Fady , De Keukeleere Katrien , Van Hecke Kristof , Van Driessche Isabel , Abbasi Alireza , Nolan Steven P. , Der Voort Pascal Van
Published: February 2017

A novel heterogeneous catalyst for the fast and totally selective oxidation of aromatic alcohols to the corresponding aldehydes.
Dielectric relaxation and anhydrous proton conduction in [C2H5NH3][Na0.5Fe0.5(HCOO)3] metal–organic frameworks
Authors: Sieradzki A. , Pawlus S. , Tripathy S. N. , Gągor A. , Ptak M. , Paluch M. , Mączka M.
Published: February 2017

First experimental direct evidence of anhydrous conductivity in the perovskite-like metal-formate framework in its ferroelectric phase.
A heterometallic ferrimagnet based on a new TTF-bis(oxamato) ligand
Authors: Cui Long , Ge Jing-yuan , Leong Chanel F. , D'Alessandro Deanna M. , Zuo Jing-Lin
Published: February 2017

An interesting heterometallic one-dimensional complex {[Cu(TTF-opba)][Mn(CH3OH)2]}n based on a π-extended TTF ligand was prepared through the method of “metalloligand”. It retains the redox activity and shows ferrimagnetic behavior.
The transformation and fate of silver nanoparticles in paddy soil: effects of soil organic matter and redox conditions
Authors: Li Min , Wang Peng , Dang Fei , Zhou Dong-Mei
Published: February 2017

Soil OM and Eh have significant impacts on the transformation and dissolution of AgNPs in paddy soil.
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells
Authors: Ren Daoyuan , Lin Dehui , Alim Aamina , Zheng Quan , Yang Xingbin
Published: February 2017

The aim of this study was to investigate the molecular mechanism underlying the immunomodulatory effect of the purified Artemisia sphaerocephala Krasch seed polysaccharide (ASKP-1) in RAW264.7 macrophages.
Quality carbon fibers from fractionated lignin
Authors: Li Qiang , Xie Shangxian , Serem Wilson K. , Naik Mandar T. , Liu Li , Yuan Joshua S.
Published: February 2017

A strategy was developed to produce quality carbon fibers from industrial waste lignin. The strategy employs an enzyme-mediator system to efficiently fractionate lignin into soluble and insoluble fractions, where the latter serves as a superior carbon fiber precursor. Mechanistic studies revealed that higher MW, less hydroxy groups, and more β-O-4 linkages improve the spinnability, crystallization, and mechanical performance of carbon fibers.
A microfluidic perfusion approach for on-chip characterization of the transport properties of human oocytes
Authors: Zhao Gang , Zhang Zhiguo , Zhang Yuntian , Chen Zhongrong , Niu Dan , Cao Yunxia , He Xiaoming
Published: February 2017

A novel sandwich structured microfluidic device based approach that allows for on-chip characterization of the transport properties of human oocytes under innocuous osmotic shock or injury to the cells.
Protection effect of intracellular melanin from Lachnum YM156 and Haikunshenxi capsule combination on adenine-induced chronic renal failure in mice
Authors: Li Shenglan , Li Jinglei , Shi Fang , Yang Liuqing , Ye Ming
Published: February 2017

This study aimed to elucidate the therapeutic effects of oral administration of intracellular melanin fromLachnumYM156 (LIM) on chronic renal failure (CRF) in mice.
Hypoglycemic and hypolipidemic effects of a polysaccharide from Lachnum YM240 and its derivatives in mice, induced by a high fat diet and low dose STZ
Authors: Wang Yufen , Su Nana , Hou Guohua , Li Jinglei , Ye Ming
Published: February 2017

Carboxymethylated and sulfated polysaccharides (CLEP and SLEP) were prepared from an exopolysaccharide previously obtained from Lachnum YM240 (LEP) by chemical modifications.
Novel 1,2,3-triazolium-based dicationic amphiphiles synthesized using click-chemistry approach for efficient plasmid delivery
Authors: Gosangi Mallikarjun , Rapaka Hithavani , Mujahid Thasneem Yoosuf , Patri Srilakshmi V.
Published: February 2017

Synthesis, characterization and evaluation of transfection efficiencies of a series of dicationic amphiphiles designed to have two diverse cationic moieties mutually linked as head group of aliphatic backbone based lipids.
Finding food: how marine invertebrates use chemical cues to track and select food
Authors: Kamio Michiya , Derby Charles D.
Published: February 2017

This review covers recent research on how marine invertebrates use chemical cues to find and select food.
SERS- and luminescence-active Au–Au–UCNP trimers for attomolar detection of two cancer biomarkers
Authors: Qu Aihua , Wu Xiaoling , Xu Liguang , Liu Liqiang , Ma Wei , Kuang Hua , Xu Chuanlai
Published: February 2017

Alpha-fetoprotein (AFP) and mucoprotein1 (mucin-1) are two important disease biomarkers.
Recent advances in the Overman rearrangement: synthesis of natural products and valuable compounds
Authors: Fernandes Rodney A. , Kattanguru Pullaiah , Gholap Sachin P. , Chaudhari Dipali A.
Published: February 2017

This review documents the reports since 2005 on the Overman rearrangement, an important C–N bond forming reaction that has been profoundly used in the synthesis of natural products, synthetic intermediates, building blocks and valuable compounds.
Chemically stable microporous hyper-cross-linked polymer (HCP): an efficient selective cationic dye scavenger from an aqueous medium
Authors: Samanta Partha , Chandra Priyanshu , Desai Aamod V. , Ghosh Sujit K.
Published: February 2017

Charge-selective capture of organic cationic dye molecules (water pollutants) from an aqueous medium has been demonstrated using a cost-effective and stable microporous hyper-cross-linked material (HCP-91@Na).
Approaches to high performance white organic light-emitting diodes for general lighting
Authors: Zhao Fangchao , Ma Dongge
Published: February 2017

A review on small molecule WOLEDs including charge balance, emissive materials, device architectures, and light out-coupling techniques is provided.
I2-Catalyzed sulfenylation of indoles and pyrroles using triethylammonium thiolates as sulfenylating agents
Authors: Fan Wei , Yang Zhen , Jiang Bo , Li Guigen
Published: February 2017

A series of new sulfenylated indoles and pyrroles with good to excellent yields were synthesized by using triethylammonium thiolates as eco-friendly sulfenylating agents and the I2/DMSO catalytic system.
Graphene/polyaniline electrodeposited needle trap device for the determination of volatile organic compounds in human exhaled breath vapor and A549 cell
Authors: Li Yu , Li JingHong , Xu Hui
Published: February 2017

In this work, a graphene/polyaniline (G/PANI) electrodeposited coating was introduced as a novel extraction phase of needle trap microextraction (NTME) for the extraction of volatile organic compounds (VOCs).
Correlations between the physical properties and chemical bonds of extruded corn starch enriched with whey protein concentrate
Authors: Yu Chen , Liu Junfei , Tang Xiaozhi , Shen Xinchun , Liu Shaowei
Published: February 2017

The effects of extrusion temperature and whey protein concentration on the physical properties of corn starch were studied. Correlations between the physical properties of the extrudates and internal chemical bonds in proteins were studied using Pearson's statistical method.
Influence of interface interaction on the moiré superstructures of graphene on transition-metal substrates
Authors: Gao Lei , Liu Yanmin , Shi Ruoyu , Ma Tianbao , Hu Yuanzhong , Luo Jianbin
Published: February 2017

The formation of moiré superstructures between graphene and its underlying substrate has attracted significant attention because it significantly influences the morphology and properties of graphene.
A Pd nanocatalyst supported on multifaceted mesoporous silica with enhanced activity and stability for glycerol electrooxidation
Authors: Almeida Thiago S. D. , Guima Katia-Emiko , Silveira Roberto M. , da Silva Gabriel C. , Martines Marco A. U. , Martins Cauê A.
Published: February 2017

The current density of glycerol electrooxidation on Pd/SiO2reached twice the values found for Pd/C. Mesosporous silica support works as a trap that confines the reactant.
The optimization of donor-to-acceptor feed ratios with the aim of obtaining black-to-transmissive switching polymers based on isoindigo as the electron-deficient moiety
Authors: Xie Huihui , Wang Min , Kong Lingqian , Zhang Yan , Ju Xiuping , Zhao Jinsheng
Published: February 2017

The polymers based on isoindigo, thiophene and ProDOT were synthesized and characterized. Black to transmissive polymers were obtained by controlling the feed ratios of the units.
Enzyme-triggered compound release using functionalized antimicrobial peptide derivatives
Authors: Mizukami Shin , Kashibe Masayoshi , Matsumoto Kengo , Hori Yuichiro , Kikuchi Kazuya
Published: February 2017

Two strategies have been proposed to develop enzyme-triggered compound release systems.
A 3D titanate aerogel with cellulose as the adsorption-aggregator for highly efficient water purification
Authors: Xiong Ye , Wang Chao , Wang Hanwei , Yao Qiufang , Fan Bitao , Chen Yipeng , Sun Qingfeng , Jin Chunde , Xu Xijin
Published: February 2017

Making full use of the hydrophilicity, hydroxyl reactivity, high strength and stiffness, low weight and biodegradability of cellulose, a novel cellulose-based adsorption-aggregator is creatively exploited.
HDAC inhibitor conjugated polymeric prodrug micelles for doxorubicin delivery
Authors: Senevirathne Suchithra A. , Washington Katherine E. , Miller Jason B. , Biewer Michael C. , Oupicky David , Siegwart Daniel J. , Stefan Mihaela C.
Published: February 2017

Amphiphilic diblock copolymers bearing histone deacetylase inhibitors (HDACis) (4-phenyl butyric acid and valproic acid) are reported for micellar drug delivery.
Fluorination of supramolecular liquid crystals – tuning tool and analytical probe
Authors: Spengler Matthias , Dong Ronald Y. , Michal Carl A. , Pfletscher Michael , Giese Michael
Published: February 2017

The impact of fluorination on the properties of photo-responsive hydrogen-bonded liquid crystals is reported and19F solid-state NMR studies provide insight into the molecular alignment of the assemblies.
Structure–property relationships of low sintering temperature scheelite-structured (1 − x)BiVO4–xLaNbO4 microwave dielectric ceramics
Authors: Pang Li-Xia , Zhou Di , Qi Ze-Ming , Liu Wei-Guo , Yue Zhen-Xing , Reaney Ian M.
Published: February 2017

A permittivity of ∼76.3 ± 0.5 and a quality factor >10 000 GHz were obtained in 0.94BiVO4–0.06LaNbO4 ceramic sintered at 800 °C.
The use of glutathione as a derivatising agent for the analysis of Michael acceptor genotoxic impurities in pharmaceuticals
Authors: Chadwick James , Kelly Anne , Quirk Emma
Published: February 2017

This work describes the development strategy and validation of an analytical method to determine trace levels of a Michael acceptor containing genotoxic impurity in a pharmaceutical intermediate.
Optically probing the localized to delocalized transition in Mo2–Mo2mixed-valence systems
Authors: Wu Yi Yang , Meng Miao , Wang Gang Yi , Feng Pengju , Liu Chun Y.
Published: February 2017

A transition of mixed-valence systems from Class II to Class III crossing the Class II–III borderline is achieved by four thienylene-bridged Mo2dimers, and is probed using spectral parameters of intervalence charge transfer absorption (band energy, intensity and shape). This study offers fresh and detailed observations of optical behaviors of MV compounds in different regimes.
Structural elucidation of a mononuclear titanium methylidene
Authors: Grant Lauren N. , Ahn Seihwan , Manor Brian C. , Baik Mu-Hyun , Mindiola Daniel J.
Published: February 2017

The first example of a structurally characterized titanium methylidene, (PN)2TiCH2, has been prepared via one-electron oxidation of (PN)2Ti(CH3) followed by deprotonation with an ylide or by H-atom abstraction using an aryloxyl radical.
Iodide and triiodide anion complexes involving anion–π interactions with a tetrazine-based receptor
Authors: Savastano Matteo , Bazzicalupi Carla , García Celeste , Gellini Cristina , López de la Torre María Dolores , Mariani Palma , Pichierri Fabio , Bianchi Antonio , Melguizo Manuel
Published: February 2017

Anion–π interactions with the ligand give rise to infinite 2D networks established through short interhalogen contacts between I3−and I−ions.
Di-pyridyl organic cation directed hybrid cuprous halogenides: syntheses, crystal structures and photochromism and photocatalysis
Authors: Lei Xiao-Wu , Yue Cheng-Yang , Wang Sai , Gao Hui , Wang Wei , Wang Ning , Yin Yun-Dong
Published: February 2017

A series of organic–inorganic hybrid cuprous halogenides have been solvothermally prepared and feature photochromism behavior and visible light driven photocatalytic activities.
Electrochemical reduction of CO2to synthesis gas with controlled CO/H2ratios
Authors: Sheng Wenchao , Kattel Shyam , Yao Siyu , Yan Binhang , Liang Zhixiu , Hawxhurst Christopher J. , Wu Qiyuan , Chen Jingguang G.
Published: February 2017

In situtransformation of Pd into β-PdH is the origin of the high selectivity for CO in the electrochemical CO2reduction reaction using Pd as the electrocatalyst.
Tuning the properties of metal–organic framework nodes as supports of single-site iridium catalysts: node modification by atomic layer deposition of aluminium
Authors: Yang Dong , Momeni Mohammad R. , Demir Hakan , Pahls Dale R. , Rimoldi Martino , Wang Timothy C. , Farha Omar K. , Hupp Joseph T. , Cramer Christopher J. , Gates Bruce C. , Gagliardi Laura
Published: February 2017

The metal–organic framework NU-1000, with Zr6-oxo, hydroxo, and aqua nodes, was modified by incorporation of hydroxylated Al(iii) ions by ALD-like chemistry with [Al(CH3)2(iso-propoxide)]2 followed by steam (ALD = atomic layer deposition). Al ions were installed to the extent of approximately 7 per node. Single-site iridium diethylene complexes were anchored to the nodes of the modified and unmodified MOFs by reaction with Ir(C2H4)2(acac) (acac = acetylacetonate) and converted to Ir(CO)2 complexes by treatment with CO. Infrared spectra of these supported complexes show that incorporation of Al weakened the electron donor tendency of the MOF. Correspondingly, the catalytic activity of the initial supported iridium complexes for ethylene hydrogenation increased, as did the selectivity for ethylene dimerization. The results of density functional theory calculations with a simplified model of the nodes incorporating Al(iii) ions are in qualitative agreement with some catalyst performance data.
Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis
Authors: Bahrami S. B. , Tolg C. , Peart T. , Symonette C. , Veiseh M. , Umoh J. U. , Holdsworth D. W. , McCarthy J. B. , Luyt L. G. , Bissell M. J. , Yazdani A. , Turley E. A.
Published: February 2017

Hyaluronan, CD44 and the Receptor for Hyaluronan-Mediated Motility (RHAMM, gene name HMMR) regulate stem cell differentiation including mesenchymal progenitor differentiation.
Facile conversion of plant oil (anethole) to a high-performance material
Authors: Tao Yangqing , He Fengkai , Jin Kaikai , Wang Jiajia , Wang Yuanqiang , Zhou Junfeng , Sun Jing , Fang Qiang
Published: February 2017

Anethole, a naturally occurring aromatic compound which can be extracted abundantly from plants like star anise, fennel and basil, has been conveniently transformed to a functional monomer in an overall yield of 81% via a two-step procedure.
Hierarchical S-doped porous carbon derived from by-product lignin for high-performance supercapacitors
Authors: Tian Jingyang , Liu Zhangming , Li Zhenghui , Wang Wenguang , Zhang Haiyan
Published: February 2017

The S-PC-L-900 exhibits a high specific capacitance and excellent rate performance.
Heme protein-mediated synthesis of PEDOT:PSS: enhancing conductivity by inhibiting heme degradation
Authors: Flores J. J. , Payne C. K. , Morris J. D.
Published: February 2017

The conductivity of PEDOT:PSS synthesized with hemoglobin is enhanced if heme degradation is inhibited during synthesis.
Controlling superstructural ordering in the clathrate-I Ba8M16P30(M = Cu, Zn) through the formation of metal–metal bonds
Authors: Dolyniuk J. , Whitfield P. S. , Lee K. , Lebedev O. I. , Kovnir K.
Published: February 2017

Formation and avoidance of M–M bonds in the clathrate framework result in extreme structural complexity.
Engineering hierarchical nanotrees with CuCo2O4 trunks and NiO branches for high-performance supercapacitors
Authors: Qiu Kangwen , Lu Min , Luo Yongsong , Du Xiwen
Published: February 2017

Hierarchical CuCo2O4@NiO core–shell nanotree arrays on porous nickel foam substrates are synthesized via a simple hydrothermal approach and further investigated as electrode materials for supercapacitors.
Pt(iv) prodrug-backboned micelle and DCA loaded nanofibers for enhanced local cancer treatment
Authors: Zhang Zhiyun , Wu Yanjuan , Kuang Gaizhen , Liu Shi , Zhou Dongfang , Chen Xuesi , Jing Xiabin , Huang Yubin
Published: February 2017

An implantable Pt(iv) prodrug-backboned micelle and DCA loaded electrospun nanofiber system was developed for local combination chemotherapy.
Convective self-assembly of π-conjugated oligomers and polymers
Authors: Botiz Ioan , Codescu Marius-Andrei , Farcau Cosmin , Leordean Cosmin , Astilean Simion , Silva Carlos , Stingelin Natalie
Published: February 2017

AFM images depicting the morphology of two films of TH13 oligomers deposited by spin casting (left) and CSA (right).