bluuebunny/crossref_metadata_2025 huggingface dataset:
Os contextos geográficos na contemporaneidade
Authors: Geraldo José
Published: March 2023

O presente livro organizado pelos pesquisadores José Geraldo Pimentel Neto, Keilha Correia da Silveira e Allison Bezerra Oliveira, teve como base os trabalhos publicados por ambos no periódico brasileiro em geografia CONTEXTO GEOGRAFICO (ISSN 2595-7236 - Qualis periódicos A4 – quadriênio – 2017-2020) da Universidade Federal de Alagoas dentro do Instituto de Geografia, Desenvolvimento e Meio Ambiente – IGDema. A organização tem por objetivo resgatar todos os artigos produzidos pelos respectivos autores supracitados para promover outra forma de divulgação e organização, em um único exemplar, dos trabalhos científicos na respectiva revista (Contexto Geográfico) com os organizadores.Tais trabalhos estão dentro de uma temporalidade de 2018 até 2022 associados ao contexto da Macrorregião Nordeste do Brasil com focos em estudos nos Estados do Maranhão e Pernambuco. Os capítulos dos livros são os artigos da revista que estão associados com estudos da geografia humana, mais especificamente nas áreas da: geografia urbana, geografia regional, geografia econômica e geografia da inovação. Todos os estudos, materializados nos capítulos de livros possuem trabalhos com práticas no planejamento e desenvolvimento urbano-regional tendo como foco as lógicas da dinâmica econômica do Nordeste, da pandemia da Covid-19, da dinâmica urbana-regional de Imperatriz-MA e do arranjo produtivo local de caprinovinocultura de Pernambuco.Portanto, se espera que com essa coletânea de artigos da revista Contexto Geográfico organizada pelos pesquisadores Geraldo Pimentel, Keilha Correia e Allison Bezerra neste livro pela editora ZION uma maior difusão dos respectivos trabalhos, tendo como resultado gerar boas práticas no processo de aprendizagem na área da geografia humana mais especificamente da geografia regional, urbana e econômica.
ANALISIS EFEKTIVITAS PERAWATAN MESIN PEMBANGKIT PADA PLTD SANANA DENGAN MENGGUNAKAN METODE OVERALL EQUIPMENT EFFECTIVENESS (OEE) DAN OVERALL RESOURCE EFFECTIVENESS (ORE)
Authors: Umasugi Mega Cahyuni , Tukan Marcus , Pattiapon Marcy L.
Published: March 2023

Dalam mengoperasikan tenaga listrik terdapat berbagai permasalahan antara lain pemakaian karena tenaga listrik selalu berubah dari waktu kewaktu, gangguan jaringan, kondisi alam dan lingkungan. Hal tersebut menyebabkan terjadinya downtime. Downtime merupakan waktu ketika mesin tidak dapat beroperasi dalam jangka waktu tertentu. Downtime yang terjadi mengakibatkan pemadaman listrik selama mesin dalam perbaikan dan berdampak pada produktivitas mesin. Produktivitas yang baik dapat dilihat dari kinerja mesin yang baik pula. Hal ini dapat ditandai dengan tingginya nilai efektivitas mesin. Tujuan dari penelitian ini untuk mengetahui efektivitas mesin dengan mengunakan metode Overall Equipment Effectiveness (OEE) dan Overall Resource Effectiveness (ORE). Hasil penelitian menunjukkan bahwa, rata-rata nilai OEE sebesar 52.05% dan nilai ORE sebesar 51.91%. Kedua nilai efektivitas mesin ini berada dibawah standar JIPM (Japan Institute of Plant Maintenance) yaitu 85%. Rendahnya nilai OEE dan ORE lebih dominan disebabkan  oleh faktor performance effeciency.
Evaluation of Cage Mate–induced Postsurgical Trauma in Mice
Authors: Tirado-Muñiz Noé , Spangler Tatum L , Van Rooyen Hollie , Oakes Jason B , Doerning Bernard J , Suckow Mark A
Published: March 2023

Although mice are social animals, individual housing is sometimes requested after surgery. We questioned whether pair-housing mice after surgery resulted in greater trauma to the surgical site as compared with single housing. We further evaluated the effect of individual housing after
surgery on the wellbeing of mice that had previously been pair-housed. Female C57Bl/6 mice (age, 6 to 8 wk) were housed as follows: group A, individually housed before and after surgery (n = 10; all 10 mice underwent surgery); group B, pair-housed before surgery but individually housed
after surgery (n = 10; all 10 mice received surgery); group C, pair-housed before and after surgery (n = 20; 10 mice underwent surgery but their cage mates did not); and group D, pair-housed before and after surgery (n = 10; all 10 mice underwent surgery). Dependent variables
were body weight, body condition, grimace based on real-time scoring, nest building, time to incorporate into nest test (TINT) score, wound trauma score, and missing wound clips. Weight was significantly different between groups A and C both before and after surgery. Mean nest building scores
were significantly higher for pair-housed (groups C and D) than for individually housed mice (groups A and B) after surgery while TINT scores were significantly higher for these same groups both before and after surgery. Mean values for body condition, grimace score, wound score, and number
of wound clips missing did not differ significantly between any groups either before or after surgery. Taken together, these results suggest that pair housing mice after surgery benefited their wellbeing but did not increase trauma to the surgical incision site or disturb wound clips as compared
with individually housed mice. Furthermore, separating previously pair-housed mice (group B) did not affect these measures as compared with individually housed mice (Group A) either before or after surgery.
How inclusive is volcanology? Insights from global bibliometric analyses
Authors: Lerner Geoffrey A , Williams George T , Meredith Elinor S , Jenkins Susanna F , Barclay Jenni
Published: March 2023

In this study, we use bibliometric methods to assess the way in which local researchers are included in volcanological publications by comparing the affiliation of authors with the country in which researched volcanoes are located. Globally, 40 % of articles about a specific volcano do not include an author whose affiliation is based in the country where the volcano is located (a locally domiciled author), while 56 % are led by authors not based in the country of the volcano. Over the past three decades, first-authorship rates among local researchers have not increased. However, local researchers have becomemore frequently included as co-authors in research led by researchers domiciled elsewhere. We provide examples of how this bibliometric analysis can be used to evaluate several specific inclusion-related topics. The results of these analyses suggest that there is room for improvement in inclusivity in volcanological research and cause for reflection on how we collaborate with international partners.
A Study on the Reorganization of the dilapidated 1st New Town
Authors:   Korean Public Land Law Association, Ahn Hye Soung , Kim Jin-Soo
Published: March 2023

Since the 1960s, Korea announced the Housing 2 million Construction Plan (1988-1992) in May 1988, due to the rapid industrialization and high economic growth of around 10% in Seoul and other metropolitan areas. Since then, the first new town has been built in Bundang, Ilsan, Pyeongchon, Sanbon, and Jung-dong, Gyeonggi-do, supplying 294,000 houses to solve urban problems such as overcrowding in Seoul, About 30 years later, social problems such as the increase of old houses and intensifying traffic congestion emerged, and each candidate made various pledges to solve the problem of the first new town in the last presidential and local elections, and the National Assembly proposed legislation on the first new town reorganization, but no effective legislation has been prepared yet. Therefore, this study aims to identify the legislation related to the reorganization of the first new city proposed by the National Assembly, analyze related problems, and present major matters to be considered in legislation. As a result of the study, the main problems related to the 1st new city reorganization project were 1) excessive safety diagnosis regulations and unrealistic standards, 2) excessively long business period, and 3) floor area rate incentive limitations, Major improvements to be considered in the reorganization project include 1) rational improvement of safety diagnosis regulations, 2) integration of project procedures, simplification 3) increase of floor area ratio by applying new and renewable energy, 4) increase of floor area ratio for developting the smart town, 5) special application for additional floor area ratio, and 6) rational setting of old new city reorganization projects.
What Do So-Called Critical Race Theory Bans Say?
Authors: Kelly Laura Beth
Published: March 2023

In the wake of racial justice protests in the United States, many states adopted policies to constrain the discussion of racism, particularly contemporary and systemic racism, in K-12 classrooms. Discursively framed as “critical race theory bans,” these policies enumerate lists of “prohibited concepts” to be eliminated from classroom instruction and curriculum materials. This brief document analysis provides an overview of first-wave prohibited concepts policies among the states to adopt such policies during the 2020-2022 legislative sessions. The analysis summarizes the prohibited concepts, teaching practices that remain allowed, and the nature of the prohibitions.
The Association between Left Ventricular End-Diastolic Diameter and Long-Term Mortality in Patients with Coronary Artery Disease
Authors: Li Qiang , Huang Haozhang , Lu Xiaozhao , Yang Yajuan , Zhang Yunhan , Chen Weihua , Lai Wenguang , Liang Guoxiao , Shi Shanshan , Wang Xiaoyan , Chen Jiyan , Chen Shiqun , Yan Xiaoming
Published: March 2023

Background: Left ventricular end-diastolic diameter (LVEDD) is a common parameter in echocardiography. Increased LVEDD is associated with left ventricular (LV) dysfunction. However, the association between LVEDD and all-cause mortality in patients with coronary artery disease (CAD) is uncertain. Methods: This study enrolled 33,147 patients with CAD who had undergone transthoracic echocardiography between January 2007 and December 2018 from the Cardiorenal Improvement study (NCT04407936). The patients were stratified into four groups based on the quartile of LVEDD (Quartile 1: LVEDD ≤43 mm, Quartile 2: 43 mm < LVEDD ≤46 mm, Quartile 3: 46 mm < LVEDD ≤51 mm, Quartile 4: LVEDD >51 mm) and were categorized into two groups (Quartile 1–3 versus Quartile 4). Survival curves were generated with the Kaplan-Meier analysis, and the differences between groups were assessed by log-rank test. Restricted cubic splines and cox proportional hazards models were used to investigate the association with LVEDD and all-cause mortality. Results: A total of 33,147 patients (average age: 63.0 ± 10.6 years; 24.0% female) were included in the final analysis. In the average follow-up period of 5.2 years, a total of 4288 patients died. The mortality of the larger LVEDD group (Quartile 4) was significantly higher than the lower LVEDD groups (Quartile 1–3) (18.05% vs 11.15%, p < 0.001). After adjusting for confounding factors, patients with the larger LVEDD (Quartile 4) had a 1.19-fold risk for all-cause mortality (95% CI: 1.09–1.30) compared with the lower quartile (Quartile 1–3). Conclusions: Enlarged LVEDD is an independent predictor of all-cause mortality in patients with CAD. LVEDD measurements may be helpful for risk stratification and providing therapeutic targets for the management of CAD patients.
Planned Reoperation after Cardiac Surgery in the Cardiac Intensive Care Unit
Authors: Wang Zhigang , Kang Yubei , Wang Zheyun , Xu Jingfang , Han Dandan , Zhang Lifang , Wang Dongjin
Published: March 2023

Background: Cardiac surgical re-exploration for bleeding is associated with increased morbidity and mortality. Whether to perform these procedures in the operating room (OR) or the Cardiac Intensive Care Unit (CICU) in uncertain. We sought to determine if the location of the reoperation would affect postoperative outcomes when a reoperation for bleeding is required following cardiac surgery. Methods: Patients who underwent planned cardiac re-explorations for bleeding at our center from January 2019 to December 2021 were retrospectively enrolled in this study. Patient outcomes were compared and analyzed. Results: Due to hemorrhagic shock, 72 patients underwent planned cardiac re-explorations, including 21 operated in the CICU and 51 in the OR. Within 12 h of the primary operation, 65 re-explorations (90.3%) were performed. The peak Vasoactive-Inotropic Score was 47.0 ± 27.4, systolic blood pressure was 89.4 ± 9.6 mmHg, central venous pressure was 12.1 ± 4.4 cmH2O, and the serum lactate was 5.5 ± 4.1 mmol/L prior to the reoperation. Multivariate logistic analysis showed that a reoperation performed in the CICU was not an independent risk factor for the occurrence of major complications. There was no significant difference in mortality between the two groups. Conclusions: Planned re-exploration for bleeding following open cardiac surgery in the CICU is feasible and safe.
The Economic Potential of Wood Carving Art and Its Marketing Strategy in Sumenep
Authors: Takdir Mohammad , Maksum Maksum , Sinawar Sinawar
Published: March 2023

This study aims to reveal three main issues that are the focus of this research, namely (1) how is the potential of wood carving art in Karduluk village as an artistic and cultural heritage of the Sumenep Madura community, (2) how is the promotion strategy of wood carving by craftsmen, and (3) what is the role of the government area in promoting the wood carving art of Karduluk village as the center of the craft industry in Madura. This study uses qualitative research to explore the promotion strategy of Karduluk village carving as a cultural heritage of the Madurese community. Data collection techniques in the field use three techniques, namely observation, interviews, and documentation. Meanwhile, the analytical method used is deep analysis to process empirical data in the field. In conducting data analysis, the researcher carried out several stages: data reduction, presenting empirical material, and verifying. There are three main findings in this research. First, is the potential of the wood carving art in Karduluk village, namely the economic potential, the potential for carving tourism development, and the potential interest of foreign consumers. Second, promotion strategies for wood carving art are done by participating in art exhibitions, personal selling, online promotion, increasing the variety of wood carving art models, maintaining product quality standards, and mentally competing. Third, the role of the government in promoting the wood carving art of Karduluk village, namely holding an exhibition of wood carving art products, establishing Karduluk village as a carving village, providing marketing capital assistance, assisting in partnership, and facilitating business licensing.
Largest aftershock nucleation driven by afterslip during the 2014 Iquique sequence
Authors: Itoh Yuji , Socquet Anne , Radiguet Mathilde
Published: March 2023

Various earthquake models predict that aseismic slip modulates the seismic rupture process but actual observations of such seismic-aseismic interaction are scarce. We analyze seismic and aseismic processes during the 2014 Iquique earthquake sequence. High-rate Global Positioning System (GPS) displacements demonstrate that most of the early afterslip is located downdip of the M 8.1 mainshock and is accompanied by decaying aftershock activity. An intriguing secondary afterslip peak is located ~120 km south of the mainshock epicenter. The area of this secondary afterslip peak likely acted as a barrier to the propagating mainshock rupture and delayed the M 7.6 largest aftershock, which occurred 27 hours later. Interevent seismicity in this secondary afterslip area ended with a M 6.1 near the largest aftershock epicenter, kicking the largest aftershock rupture in the same area. Hence, the interevent afterslip likely promoted the largest aftershock nucleation by destabilizing its source area, favoring a rate-dependent cascade-up model.
Terms of debate: Consensus definitions to guide the scientific discourse on visual distraction
Authors: Liesefeld Heinrich R , Lamy Dominique , Gaspelin Nick , Geng Joy , Kerzel Dirk , Schall Jeffrey , Allen Harriet A , Anderson Brian A. , Boettcher Sage , Busch Niko , Carlisle Nancy Beth , Colonius Hans , Draschkow Dejan , Egeth Howard , Leber Andrew B. , Müller Hermann , Röer Jan Philipp , Schubö Anna , Slagter Heleen A , Theeuwes Jan , Wolfe Jeremy
Published: March 2023

Hypothesis-driven research rests on clearly articulated scientific theories. The building blocks for communicating these theories are scientific terms. Obviously, communication – and thus, scientific progress – is hampered if the meaning of these terms varies idiosyncratically across (sub)fields and even across individual researchers within the same subfield. We have formed an international group of experts representing various theoretical stances with the goal to homogenize the use of the terms that are most relevant to the field of visual distraction in visual search. Our discussions revealed striking heterogeneity and we had to invest much time and effort to increase our mutual understanding of each other’s use of central terms, which turned out to be strongly related to our respective theoretical positions. We present the outcomes of these discussions in a glossary and provide some context in several essays. Specifically, we explicate how central terms are used in the distraction literature and consensually sharpen their definitions in order to enable communication across theoretical standpoints. Where applicable, we also explain how the respective constructs can be measured. We believe that this novel type of adversarial collaboration can serve as a model for other fields of psychological research that strive to build a solid groundwork for theorizing and communicating by establishing a common language. For the field of visual distraction, the present paper should facilitate communication across theoretical standpoints and may serve as an introduction and reference text for newcomers.
Obsessive-Compulsive Symptoms and Sound Sensitivities: Comparing Misophonia and Hyperacusis
Authors: Castro Ariana , Lindberg Ragnar Richard Dean , Kim Gibbeum , Brennan Callie , Jain Namitha , Khan Rafay A. , Husain Fatima , Berenbaum Howard
Published: March 2023

Several previous studies have found an association between misophonia and obsessive-compulsive (O-C) symptoms. The goal of the present research was to examine the relationship between O-C symptoms and two different types of sound sensitivities: misophonia and hyperacusis. We did so in a large on-line sample of university students (N = 1,094), a subset of whom completed in-person audiological and psychological assessments (N = 102). We utilized a multi-trait, multi-method approach, measuring misophonia, hyperacusis, and O-C symptoms using both questionnaires and either clinician ratings or laboratory assessment. For the sake of examining specificity, interview-based depression ratings were also examined. The associations were generally consistent regardless of how O-C symptoms, misophonia, and hyperacusis were measured – O-C symptoms were associated with both types of sound sensitivities. Thus, the results suggest that sensory sensitivities, rather than misophonia specifically, are associated with O-C symptoms. Depression symptoms were not significantly associated with hyperacusis and were less strongly associated with misophonia than were O-C symptoms, suggesting that the associations between O-C symptoms and sound sensitivities are not simply artifacts of shared variance with general psychological distress.
Awareness of Implicit Attitudes Revisited: A Meta-Analysis on Replications Across Samples and Settings
Authors: Goedderz Alexandra , Rahmani Azad Zahra , Hahn Adam
Published: March 2023

A long-standing debate in social psychology is whether the cognitions reflected on implicit measures are unconscious. Research by Hahn et al. (2014) has documented that people are able to predict the patterns of their results on Implicit Association Tests (IATs) towards five pairs of social groups prospectively. The present article presents a meta-analysis of 17 published and unpublished exact replication studies conducted by or in close supervision of the original author. Replicating Hahn et al., participants in all 17 studies were able to accurately predict the patterns of their IAT results (meta-analytical within-subject correlation: b = .44; corrected average within-subjects correlation r = .56). This prediction accuracy effect was smaller for online (b = .27; corrected r = .37) than lab (b = .47; corrected r = .61) studies, as well as for general-public (b = .27; corrected r = .36) as opposed to student samples (b = .47; corrected r = .60). Moreover, predictions fully explained implicit-explicit relations, and they seemed to reflect unique insights into participants’ own cognitions beyond mere knowledge about normatively expected patterns of implicit responses. This pattern of results remained the same across samples, settings, countries (Canada, US, and Germany), and languages (English vs. German). Further analyses suggested that lower prediction accuracy in online samples seems to partly reflect a suppression effect from higher consistency between traditional explicit evaluations and predictions. Controlling for explicit evaluations (which exerted a negative unique effect on IAT scores beyond IAT score predictions) reduced the difference between online and lab studies substantially. Together, the results strengthen the hypothesis that the cognitions reflected on implicit evaluations are largely accessible to conscious awareness.
The perceived feasibility of behavior change is positively associated with support for domain-matched climate policies
Authors: Kukowski Charlotte Anna , Hofmann Wilhelm , Roozenbeek Jon , Linden Sander van der , Vandenbergh Michael , Nielsen Kristian Steensen
Published: March 2023

Significant greenhouse gas emission reductions can come from changing consumer behaviors. While the technical mitigation potential of such changes is known, evidence of their feasibility is less abundant. In a pre-registered international survey with mostly North American and European participants (n = 7,349), we examined the predictors and interrelationships between people’s perceived feasibility of changing consumer behaviors with low and high climate impact, their performance of these behaviors, and their support for behavior-regulating policies. Using regression analyses, we found that the key predictors of perceived behavioral plasticity, policy support, and behavioral performance were the perceived need for system change and environmental identity with more mixed results for the perceived effectiveness of individual action and trust in government. Our findings underscore the untapped potential of individual behavior change to accelerate climate change mitigation, demonstrating considerable plasticity in several high-impact behaviors and that individual behavior change need not preclude support for political change.
Theatre in the Age of Digital Technologies
Authors: Tonkoshkura Oleg
Published: March 2023

The paper studies the functioning of modern theater in regard to the use of digital technologies. New digital technologies affect the development of theater as an art form, with unique forms of performances, new theatrical specialties, specific technologies of stage creativity, and theatrical work appearing. Currently, the technification of theatre stage design, a process of mutual influence ofscience and art, goes along with the aestheticization of theatre equipment. The concept of the virtual and interactive theatre was also clarified due to the influence of digital culture. In this context, introduction of new technologies in theatre is associated with the changes in the stage design imagery linked to the change in worldview, with the development ofsocio-aesthetic features of the clash of different eras, the enhancement of the theatre technical equipment, which contributes to the emergence of new genre precedents in theatre. At the same time, digital technologies in modern stage design made it possible to form a new culture of scenography, adding a diverse, spatial composition, special effects, hyperrealism or expressionistic blur to the space of the stage. Digital culture and its new technologies contribute to the globalization of the perception of theatrical art, including online broadcasts of performances, where new technologies radically influence the dynamics of the artistic process and serve as a source of diversity in the existing forms of theatrical discourse and its artistic practice.
Modern Forms of Portraiture as an Instrument for Creating a Banner Memory
Authors: Abramova Marianna
Published: March 2023

At the turn of the 21st century, portraiture underwent significant transformations. While there were many attempts to “reinvent” the portrait as a genre, it has been flourishing in a new status—now as an instrument for image creation. Being one of the important forms of preservation and transmission of the memory of an individual, portraiture isinfluenced by the algorithms of advertisement. At present, the fixation of our memories through portraiture becomes the vehicle of the image ideology that changes perception and a general understanding of the role and place of man both in history and in the modern highly competitive symbolic field of culture. The paper considers new forms and means of portraiture in connection with the layering of advertising search queries. In addition, the paper analyzes the approaches to preserving the cultural memory of an individual through portraiture within the mass culture and in the context of the development of digital technologies.
Symphony Features in The Ukrainian Quintet by Borys Liatoshynsky
Authors: Savchuk Igor
Published: March 2023

The paper analyses the features of a symphony style inThe Ukrainian Quintet by Borys Liatoshynsky, finding that the most researchers consider this work to be a symphony written for string quartet and piano. The grounds for this statement lie in the ideological depth of the dramatic concept of the tragic conflict in The Quintet, the scale of thematic transformations, the introduction of monothematism as the basic principle of composition, the use of semantic, genre, modal, melodic and intonation, as well as tonal and harmonic symbolism. The introduction of symphonism as the main method of building the concept led to a more ambitious interpretation of the chamber quintet genre. The author highlights the important role of polyphony in the creation of a multifaceted musical space at different levels of composition—from content, form creating, genre specificity to texture, rhythmic, melodic, and timbre development. Thus, the study dwells on the manifestations of symphonism in the musical drama of The Ukrainian Quintet.
Tradition et modernité du droit budgétaire local
Authors: Dussart Vincent
Published: March 2023

Le droit budgétaire local a été fondé en empruntant les règles fondamentales de celui de l’État. Des principes budgétaires à l’application de la règle des quatre temps alternés il a longtemps été marqué d’une certaine forme de tradition. Cependant, le droit des finances locales est désormais porteur d’éléments de modernisation qui ne vont pas sans un accroissement de sa complexité.
Opposed evolution of the osseous and soft parts of progestin-associated osteomeningioma after progestin intake discontinuation
Authors: Florea Simona M. , Passeri Thibault , Abbritti Rosaria , Bernat Anne L. , Fontanel Sylvie , Yoldjian Isabelle , Funck-Brentano Thomas , Weill Alain , Mandonnet Emmanuel , Froelich Sébastien
Published: March 2023

OBJECTIVE

Numerous studies have confirmed a strong association between progestins and meningiomas and the regression and/or stabilization of meningiomas after discontinuation of treatment. Osteomeningiomas represent a small subgroup of meningiomas that appear to be more common among progestin-related meningiomas. However, the specificity of the behavior of this subset of meningiomas after discontinuation of progestin has not yet been assessed.

METHODS

Thirty-six patients (mean age 49.5 years) who presented with at least one progestin-related osteomeningioma (48 tumors total) were identified from a prospectively collected database of patients and had been referred to our department for meningioma and had documented use of cyproterone acetate, nomegestrol acetate, and/or chlormadinone acetate. Hormonal treatment was stopped at the time of diagnosis for all the patients, and the clinical and radiological evolution of this subgroup of tumors was evaluated.

RESULTS

For half of the 36 patients, treatment was prescribed for signs of hyperandrogenism, such as hirsutism, alopecia, or acne. Most lesions were spheno-orbital (35.4%) or frontal (31.2%). Although the tissular part of the meningioma shrank in 77.1% of cases, the osseous part exhibited discordant behavior with 81.3% showing volume progression. The combination of estrogens, as well as the prolonged duration of progestin treatment, seems to increase the risk of progression of the osseous part after treatment discontinuation (p = 0.02 and p = 0.028, respectively). No patient required surgical treatment at diagnosis or during the study.

CONCLUSIONS

These results show that while the soft intracranial part of progestin-related osteomeningioma tumor is the most likely to regress after treatment discontinuation, the bony part is more likely to increase in volume. These findings suggest the need for careful follow-up of these patients, especially those with tumors near the optical apparatus.
BOLD frequency–dependent alterations in resting-state functional connectivity by pallidal deep brain stimulation in patients with Parkinson’s disease
Authors: Li Zhenghao , Lai Yijie , Li Jun , He Naying , Li Dianyou , Yan Fuhua , Zhang Yuyao , Zhang Chencheng , Sun Bomin , Wei Hongjiang
Published: March 2023

OBJECTIVE

Functional MRI (fMRI) has been used to investigate the therapeutic mechanisms underlying deep brain stimulation (DBS) for Parkinson’s disease (PD). However, the alterations in stimulation site–seeded functional connectivity induced by DBS at the internal globus pallidus (GPi) remain unclear. Furthermore, whether DBS-modulated functional connectivity is differentially affected within particular frequency bands remains unknown. The present study aimed to reveal the alterations in stimulation site–seeded functional connectivity induced by GPi-DBS and to examine whether there exists a frequency band effect in blood oxygen level–dependent (BOLD) signals related to DBS.

METHODS

Patients with PD receiving GPi-DBS (n = 28) were recruited for resting-state fMRI with DBS on and DBS off under a 1.5-T MR scanner. Age- and sex-matched healthy controls (n = 16) and DBS-naïve PD patients (n = 24) also received fMRI scanning. The alterations in stimulation site–seeded functional connectivity in the stimulation-on state versus stimulation-off state, as well as the relationship between alterations in connectivity and improvement in motor function induced by GPi-DBS, were examined. Furthermore, the modulatory effect of GPi-DBS on the BOLD signals within the 4 frequency subbands (slow-2 to slow-5) was investigated. Finally, the functional connectivity of the motor-related network, consisting of multiple cortical and subcortical regions, was also examined among the groups. In this study, p < 0.05 with Gaussian random field correction indicates statistical significance.

RESULTS

Functional connectivity seeding from the stimulation site (i.e., the volume of tissue activated [VTA]) increased in the cortical sensorimotor areas and decreased in the prefrontal regions with GPi-DBS. Alterations in connectivity between the VTA and the cortical motor areas were correlated with motor improvement by pallidal stimulation. The alterations in connectivity were dissociable between the frequency subbands in the occipital and cerebellar areas. The motor network analysis indicated decreased connectivity among most cortical and subcortical regions but increased connectivity between the motor thalamus and the cortical motor area in patients with GPi-DBS compared with those in DBS-naïve patients. The DBS-induced decrease in several cortical-subcortical connectivities within the slow-5 band correlated with motor improvement with GPi-DBS.

CONCLUSIONS

These findings indicate that the alterations in functional connectivity from the stimulation site to the cortical motor areas, as well as multiple connectivities among the motor-related network, were associated with the efficacy of GPi-DBS for PD. Furthermore, the changing pattern of functional connectivity within the 4 BOLD frequency subbands is partially dissociable.
Reappraisal of the anatomy of the frontotemporal branches of the facial nerve
Authors: Nunez Maximiliano Alberto , Mohyeldin Ahmed , Marotta Dario A. , Vigo Vera , Asmaro Karam , Xu Yuanzhi , Cohen-Gadol Aaron A. , Fernandez-Miranda Juan C.
Published: March 2023

OBJECTIVE

The anatomy of the temporal branches of the facial nerve (FN) has been widely described in the neurosurgical literature because of its relevance in anterolateral approaches to the skull base and implication in frontalis palsies from these approaches. In this study, the authors attempted to describe the anatomy of the temporal branches of the FN and identify whether there are any FN branches that cross the interfascial space of the superficial and deep leaflets of the temporalis fascia.

METHODS

The surgical anatomy of the temporal branches of the FN was studied bilaterally in 5 embalmed heads (n = 10 extracranial FNs). Exquisite dissections were performed to preserve the relationships of the branches of the FN and their relationship to the surrounding fascia of the temporalis muscle, the interfascial fat pad, the surrounding nerve branches, and their final terminal endpoints near the frontalis and temporalis muscles. The authors correlated their findings intraoperatively with 6 consecutive patients with interfascial dissection in which neuromonitoring was performed to stimulate the FN and associated twigs that were observed to be interfascial in 2 of them.

RESULTS

The temporal branches of the FN stay predominantly superficial to the superficial leaflet of the temporal fascia in the loose areolar tissue near the superficial fat pad. As they course over the frontotemporal region, they give off a twig that anastomoses with the zygomaticotemporal branch of the trigeminal nerve, which crosses the superficial layer of the temporalis muscle, spanning the interfascial fat pad, and then pierces the deep temporalis fascial layer. This anatomy was observed in 10 of the 10 FNs dissected. Intraoperatively, stimulation of this interfascial segment yielded no facial muscle response up to 1 mA in any of the patients.

CONCLUSIONS

The temporal branch of the FN gives off a twig that anastomoses with the zygomaticotemporal nerve, which crosses the superficial and deep leaflets of the temporal fascia. Interfascial surgical techniques aimed at protecting the frontalis branch of the FN are safe in their efforts to protect against frontalis palsy with no clinical sequelae when executed properly.
Femoral access site complications following neurointerventional procedures: economic implications at a single center
Authors: Joshi Krishna C. , Khanna Ryan , Beer-Furlan André , McLaughlin Elizabeth , Chen Michael , Crowley R. Webster , Munich Stephan A.
Published: March 2023

OBJECTIVE

Transfemoral access (TFA) has been the traditional route of arterial access for neurointerventional procedures. Femoral access site complications may occur in 2%–6% of patients. Management of these complications often requires additional diagnostic tests or interventions, each of which may increase the cost of care. The economic impact of a femoral access site complication has not yet been described. The objective of this study was to evaluate the economic consequences of femoral access site complications.

METHODS

The authors conducted a retrospective review of patients undergoing neuroendovascular procedures at their institute and identified those who experienced femoral access site complications. The subset of patients experiencing these complications during elective procedures was matched in a 1:2 fashion to a control group undergoing similar procedures and not experiencing an access site complication.

RESULTS

Femoral access site complications were identified in 77 patients (4.3%) over a 3-year period. Thirty-four of these complications were considered major, requiring blood transfusion or additional invasive treatment. There was a statistically significant difference in total cost ($39,234.84 vs $23,535.32, p = 0.001), total reimbursement ($35,500.24 vs $24,861.71, p = 0.020) and reimbursement minus cost (−$3734.60 vs $1326.39, p = 0.011) between the complication and control cohorts in elective procedures, respectively.

CONCLUSIONS

Although occurring relatively infrequently, femoral artery access site complications increase the cost of care for patients undergoing neurointerventional procedures; how this influences the cost effectiveness of neurointerventional procedures warrants further investigation.
Validation of an automated machine learning algorithm for the detection and analysis of cerebral aneurysms
Authors: Colasurdo Marco , Shalev Daphna , Robledo Ariadna , Vasandani Viren , Luna Zean Aaron , Rao Abhijit S. , Garcia Roberto , Edhayan Gautam , Srinivasan Visish M. , Sheth Sunil A. , Donner Yoni , Bibas Orin , Limzider Nicole , Shaltoni Hashem , Kan Peter
Published: March 2023

OBJECTIVE

Machine learning algorithms have shown groundbreaking results in neuroimaging. The authors herein evaluated the performance of a newly developed convolutional neural network (CNN) to detect and analyze intracranial aneurysms (IAs) on CTA.

METHODS

Consecutive patients with CTA studies between January 2015 and July 2021 at a single center were identified. The ground truth determination of cerebral aneurysm presence or absence was made from the neuroradiology report. The primary outcome was the performance of the CNN in detecting IAs in an external validation set, measured using area under the receiver operating characteristic curve statistics. Secondary outcomes included accuracy for location and size measurement.

RESULTS

The independent validation imaging data set consisted of 400 patients with CTA studies, median age 40 years (IQR 34 years) and 141 (35.3%) of whom were male; 193 patients (48.3%) had a diagnosis of IA on neuroradiologist evaluation. The median maximum IA diameter was 3.7 mm (IQR 2.5 mm). In the independent validation imaging data set, the CNN performed well with 93.8% sensitivity (95% CI 0.87–0.98), 94.2% specificity (95% CI 0.90–0.97), and a positive predictive value of 88.2% (95% CI 0.80–0.94) in the subgroup with an IA diameter ≥ 4 mm.

CONCLUSIONS

The described Viz.ai Aneurysm CNN performed well in identifying the presence or absence of IAs in an independent validation imaging set. Further studies are necessary to investigate the impact of the software on detection rates in a real-world setting.
Endovascular treatment as first-line therapy in Spetzler-Martin grade III brain arteriovenous malformations: a multicenter retrospective study
Authors: Burel Julien , Papagiannaki Chrysanthi , Sourour Nader , Talbi Atika , Garnier Matthieu , Hermary Capucine , Talaat Maichael , Boch Anne-Laure , Nouet Aurélien , Lenck Stéphanie , Premat Kévin , Shotar Eimad , Clarençon Frédéric
Published: March 2023

OBJECTIVE

The management of Spetzler-Martin grade (SMG) III brain arteriovenous malformations (bAVMs) may be challenging, whatever the exclusion treatment modality chosen. The purpose of this study was to evaluate the safety and effectiveness of endovascular treatment (EVT) as a first-line treatment of SMG III bAVMs.

METHODS

The authors performed a retrospective, two-center, observational cohort study. Cases recorded in institutional databases between January 1998 and June 2021 were reviewed. Patients who were ≥ 18 years of age, had ruptured or unruptured SMG III bAVMs, and received EVT as first-line therapy were included. Baseline characteristics of patients and bAVMs, procedure-related complications, clinical outcome according to the modified Rankin Scale, and angiographic follow-up were assessed. The independent risk factors of procedure-related complications and poor clinical outcome were assessed using binary logistic regression.

RESULTS

One hundred sixteen patients with 116 SMG III bAVMs were included. The mean age of the patients was 41.9 ± 14.0 years. The most common presentation was hemorrhage (66.4%). Forty-nine (42.2%) bAVMs were found to be completely obliterated by EVT alone at follow-up. Complications occurred in 39 patients (33.6%), including 5 (4.3%) major procedure-related complications. There was no independent predictor of procedure-related complication. Age > 40 years and poor preoperative modified Rankin Scale score were the independent predictors of poor clinical outcome.

CONCLUSIONS

EVT of SMG III bAVMs provides encouraging results but needs further improvement. When the embolization procedure performed with intent to cure appears difficult and/or risky, a combined technique (with microsurgery or radiosurgery) may be a safer and more effective strategy. In terms of safety and effectiveness, the benefit of EVT (alone or included in a multimodal management strategy) for SMG III bAVMs needs to be confirmed by randomized controlled trials.
Oscillation analysis as a supporting element toward safe and reliable lumbar catheter intracranial pressure monitoring
Authors: Früh Anton , Wolf Stefan , Wessels Lars , Vajkoczy Peter , Hecht Nils
Published: March 2023

OBJECTIVE

Lumbar drainage of cerebrospinal fluid for treatment of refractory increased intracranial pressure (ICP) is associated with the risk of infratentorial herniation, but real-time biomarkers for signaling herniation at bedside are lacking. Here, the authors tested whether an alteration of pulsatile waveform conduction across the level of the foramen magnum could serve as an indicator of insufficient hydrostatic communication and impending herniation.

METHODS

This prospective observational cohort study included patients with severe acute brain injury who underwent continuous external ventricular drain monitoring of ICP and lumbar drain pressure monitoring. Continuous recordings of ICP, lumbar pressure (LP), and arterial blood pressure (ABP) were screened throughout a recording period of 4–10 days. Pressure differences between ICP and LP > 5 mm Hg for 5 minutes were defined as a Δ-event, implicating nonsufficient hydrostatic communication. During this period, oscillation analysis of the ICP, LP, and ABP waveforms was performed by determining the eigenfrequencies (EFs) and their amplitudes (AEF) via Fourier transformation scripted in Python.

RESULTS

Of 142 patients, 14 exhibited a Δ-event, with a median (range) ICP of 12.2 (10.7–18.8) mm Hg and LP of 5.6 (3.3–9.8) mm Hg during 2993 hours of recording time. The AEF ratio between ICP and LP (p < 0.01) and between ABP and LP (p = 0.032) increased significantly during Δ-events compared with the baseline values determined 3 hours prior to the event. The ratio between ICP and ABP remained unaffected.

CONCLUSIONS

Oscillation behavior analysis of LP and ABP waveforms during controlled lumbar drainage may serve as a personalized, simple, and effective biomarker to signal impending infratentorial herniation in real time without the need for simultaneous ICP monitoring.
Evaluation of lymphopenia as a predictor of postoperative mortality and major complications in patients undergoing surgery for metastatic spine tumors
Authors: Ryvlin Jessica , Hamad Mousa K. , Langro Justin , Wang Benjamin , Patel Pavan , De la Garza Ramos Rafael , Murthy Saikiran G. , Gelfand Yaroslav , Yassari Reza
Published: March 2023

OBJECTIVE

Lymphopenia is often seen in advanced metastatic disease and has been associated with poor postoperative outcomes. Limited research has been done to validate this metric in patients with spinal metastases. The objective of this study was to evaluate the capability of preoperative lymphopenia to predict 30-day mortality, overall survival (OS), and major complications in patients undergoing surgery for metastatic spine tumors.

METHODS

A total of 153 patients who underwent surgery for metastatic spine tumor between 2012 and 2022 and met the inclusion criteria were examined. Electronic medical record chart review was conducted to obtain patient demographics, comorbidities, preoperative laboratory values, survival time, and postoperative complications. Preoperative lymphopenia was defined as < 1.0 K/μL based on the institution’s laboratory cutoff value and within 30 days prior to surgery. The primary outcome was 30-day mortality. Secondary outcomes were OS up to 2 years and 30-day postoperative major complications. Outcomes were assessed with logistic regression. Survival analyses were done using the Kaplan-Meier method with log-rank test and Cox regression. Receiver operating characteristic curves were plotted to classify the predictive ability of lymphocyte count as a continuous variable on outcome measures.

RESULTS

Lymphopenia was identified in 47% of patients (72 of 153). The overall 30-day mortality rate was 9% (13 of 153). In logistic regression analysis, lymphopenia was not associated with 30-day mortality (OR 1.35, 95% CI 0.43–4.21; p = 0.609). The mean OS in this sample was 15.6 months (95% CI 13.9–17.3 months), with no significant difference between patients with lymphopenia and those with no lymphopenia (p = 0.157). Cox regression analysis did not show an association between lymphopenia and survival (HR 1.44, 95% CI 0.87–2.39; p = 0.161). The major complication rate was 26% (39 of 153). In univariable logistic regression analysis, lymphopenia was not associated with the development of a major complication (OR 1.44, 95% CI 0.70–3.00; p = 0.326). Finally, receiver operating characteristic curves generated poor discrimination between lymphocyte count and all outcomes, including 30-day mortality (area under the curve 0.600, p = 0.232).

CONCLUSIONS

This study does not support prior research that had shown an independent association between low preoperative lymphocyte level and poor postoperative outcomes following surgery for metastatic spine tumors. Although lymphopenia may be used to predict outcomes in other tumor-related surgeries, this metric may not hold a similar predictive capability in the population undergoing surgery for metastatic spine tumors. Further research into reliable prognostic tools is needed.