bluuebunny/crossref_metadata_2025 huggingface dataset:
Héroes, rituales y culto: la tragedia y el caso de Hipólito
Authors: Gambon Lidia
Published: November 2021

Aunque, al igual que sucede con otros héroes griegos, Hipólito no fue únicamente una figura del mito, sino también del culto, esta relación muestra importantes aspectos discordantes. Nos proponemos, en el presente artículo, puntualizar estas discordancias, centrándonos en tres puntos significativos del tratamiento trágico (la localización de la historia, el nombre del personaje y la relación del héroe con la divinidad de culto). Con ello procuramos destacar que Hipólito, una figura de culto eminente en Trecén, fue en Atenas esencialmente un héroe trágico, y orientar nuestras conclusiones hacia la importancia que para ello tuvo un aspecto que Eurípides remarcó en Hipólito (la única tragedia completa conservada): la tensión y complementariedad entre Afrodita y Ártemis.
Manajemen Anestesia pada Evakuasi Epidural Haemorrhage (EDH) dengan Pendarahan Masif
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Brawijaya/Dr. Saiful Anwar General Hospital Malang, Indonesia, Huda Nurul , Hartiyo Laksono Buyung
Published: November 2021

Traumatic brain injury causes mortality and morbidity worldwide. Epidural Haemorrhage (EDH) is a form of head injury where time is an indicator that must be considered in its management. The main focus during traumatic brain injury management is patient stabilization and control of intracranial pressure, as well as maintaining brain oxygenation and perfusion. Subsequently, surgical decompression was performed. Evacuation and bleeding control should be done in a short time to avoid further injury. The practice of neuroanesthesia, as a support in the management of traumatic brain injuries, is often associated with blood loss that results in anemia during the intraoperative and postoperative periods. Although anemia correlates with poor outcome in brain-injured patients, red blood cell transfusion to correct anemia also correlates with poor outcome in patients. There are still no clear recommendations regarding the administration of transfusions, whether restrictive or massive, regarding the benefits provided. Male patient, age 51 years with complaints of decreased consciousness and vomiting, referred from the previous hospital with a diagnosis of moderate head injury 225 with 96cc temporoparietal EDH, 11mm midline shift to the right, and cerebral edema. During the operation period, there was massive bleeding that interfered with the hemodynamic status so that blood components were transfused until a stable hemodynamic status was obtained. In postoperative care in the ICU, the patient is relatively in good condition.
Perbedaan Respon Hemodinamik terhadap Penambahan Clonidin 1 dan 2 mcg/kgbb pada Scalp Block untuk Operasi Kraniotomi
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Sebelas Maret/Dr.  Moewardi Surakarta, Indonesia, Afif Syarif , Ardana Arianto Tri , Budi Santosa Sugeng
Published: November 2021

Bacground and Objective: The addition of a levobupivacaine scalp block is effective in reducing hemodynamic responses such as blood pressure, mean arterial pressure (MAP) and pulse rate, especially when pinning, skin incisions, and durameter incisions in craniotomy. Adjuvants are often added to local anesthetics to enhance and prolong the analgesic effect of peripheral nerve blocks. Clonidine has a synergistic action with local anesthetic agents. Clonidine increases sensory and motor blocks in both peripheral and neuraxial blocks. The common dose is 2 mcg/kgbw. The aim of this study was to determine the effectiveness of adding clonidine 2 mcg/kg and 1 mcg/kg on scalp block as craniotomy analgesic. Subjects and Methods: Study on 30 patients met the inclusion criteria. Subjects were divided into three groups, group I: scalp block with levobupivacain 0.25%, group II: scalp block plus clonidine 1 mcg/kg, group III: scalp block plus clonidine 2mcg/kg. All patients were treated with general anesthesia according to the standard then assessed their blood pressure, MAP, pulse rate before intubation, pinning, skin incision and duramater incision. Results: There was a significant difference in the addition of clonidine with the control group, especially in the pulse and diastolic rates. Clonidine 2 mcg/kg at several times showed a significant difference compared to 1 mcg/kgbb dose. Conclusion: The clonidine addition to scalp block of levobupivacaine was effective in maintening hemodynamic responses, especially pulse rate and diastolic blood pressure.
Disfungsi Kognitif Post Operatif pada Geriatri
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya/Dr.  Moeh. Hoesin General Hospital Palembang, Indonesia, Dewi Maharani Nurmala , A. Halimi Radian ,   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, Indonesia, Mafiana Rose ,   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya/Dr.  Moeh. Hoesin General Hospital Palembang, Indonesia, Gaus Syafruddin ,   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Hasanuddin/Dr.  Wahidin General Hospital Makassar, Indonesia
Published: November 2021

Postoperative Cognitive Dysfunction (POCD) is a neurocognitive disorder characterized by decreased cognitive performance after surgery and anesthesia. POCD is a complication characterized by memory impairment, decreased information processing and reduced attention, accompanied by changes in mood and personality. The incidence of POCD in elderly patients (> 60 years) was approximately 25.8% within seven days after surgery and 10% within three months after surgery. The risk factors and etiology that lead to POCD can be reduced by good patient education, patient care and proper sanitation can prevent the tendency of POCD symptoms in these patients. Examination can be done with the learning test, the word learning test, the tracing test, the manual dexterity test, the ability test to remember a sequence of numbers. Mini Mental Status Examination (MMSE) as a screening test for dementia. MMSE is sometimes used to measure POCD. MMSE can be used in routine clinical practice to identify preoperative subclinical dementia that would put patients at a higher risk of developing POCD. Management in POCD includes two approaches, namely rapid diagnosis and prevention of POCD symptoms. Prevention by knowing the risk factors preoperative, intraoperative and postoperative. In patients with persistent POCD, it has a negative impact on quality of life, subjective memory performance, emotional symptoms, and possible health consequences such as dementia and premature death.
Efektifitas pupuk organik cair limbah ikan dan Trichoderma sp terhadap pertumbuhan dan hasil tanaman kailan (Brassica oleraceae sp) pada sistem hidroponik substrat
Authors: Abror M. , Harjo Rakhmad Pavi
Published: November 2021

Penelitian bertujuan untuk mengetahui pengaruh pupuk organik cair limbah ikan dan Trichoderma sp terhadap pertumbuhan dan hasil tanaman kailan. Penelitian dilaksanakan di Green House Fakultas Pertanian Universitas Muhammadiyah Sidoarjo dari bulan Mei sampai Juli 2016. Penelitian ini  secara faktorial dengan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari dua faktor perlakuan. Faktor I adalah kosentrasi pupuk organik cair yaitu (P0) 0 ml/liter, (P1) 7 ml/liter, (P2) 10 ml/liter, (P3) 13 ml/liter, dan Faktor II adalah penggunaan Trichoderma sp yaitu T0 (Tanpa Pengunaan Trichoderma sp) dan T1 (Penggunaan Trichoderma sp). Dari kedua faktor tersebut didapat 8 kombinasi perlakuan dan diulang sebanyak 3 kali, data yang didapat di Anailisis Of Variance (Annova) serta dilanjut dengan BNJ 5%. Variabel yang diamati yaitu panjang tanaman, jumlah daun, diameter batang, bobot basah brangkasan dan bobot kering brangkasan tanaman. Hasil penelitian menunjukkan Kombinasi antara pupuk organik cair limbah ikan dan Trichoderma sp menunjukkan interaksi terhadap semua variabel pengamatan yaitu panjang tanaman, jumlah daun, diameter batang, bobot basah brangkasan dan bobot kering  brangkasan. Pada perlakuan pupuk organik cair limbah ikan berpengaruh terhadap variabel panjang tanaman dan jumlah daun. Demikian juga Perlakuan Trichoderma sp berpengaruh terhadap panjang tanaman dan jumlah daun Kata Kunci ; pupuk organik cair limbah ikan, kailan, Trichoderma sp.
KARAKTERISASI PLASMA NUTFAH BUAH LOKAL DI KABUPATEN LIMA PULUH KOTA DAN KOTA SOLOK
Authors: Kusumawati Aries , Putri Nurwanita Ekasari , Azhar Nur Oktafiani , Swasti Etti
Published: November 2021

Karakterisasi plasma nutfah buah-buahan lokal yang terancam punah di kabupaten Lima Puluh Kota dan kota Solok. Tujuan dari penelitian ini adalah untuk mengeksplorasi dan mengkarakterisasi pohon buah lokal yang ada di kabupaten Lima Puluh Kota dan kota Solok, Sumatera Barat. Hasil dari inventarisasi pengkarakteran tanaman buah lokal ini akan berguna nantinya untuk dijadikan pedoman dan acuan bagi program pemuliaan tanaman buah lokal yang ada di daerah tersebut. Penelitian eksplorasi ini dilaksanakan dari bulan Juli – Desember 2015 di kabupaten Lima Puluh Kota dan kota Solok, Provinsi Sumatera Barat. Pelaksanaan penelitian dilakukan dengan metode survei dengan pengambilan contoh secara sengaja (purposive sampling). Pengukuran terhadap tanaman sampel yang diidentifikasi dan dikarakterisasi dilakukan pada kedua organ vegetatif (daun dan batang) serta generatif (buah dan biji) jika tanaman ditemukan dalam keadaan berbuah. Hasil penelitian ini memberikan informasi bahwa pohon buah lokal menujukkan keragaman fenotipe yang luas pada beberapa karakter. Usaha konservasi telah dilakukan untuk memelihara koleksi biji melalui pembibitan.
BIOAKTIVITAS SENYAWA TURUNAN ALKALOID KINKONA
Authors: Ernawati Teni
Published: November 2021

Alkaloid kinkona adalah senyawa aktif yang terkandung dalam tanaman kina.  Alkaloid kinkona diisolasi dari kulit batang pohon kina. Secara kimia, alkaloid kinkona memiliki 2 bagian molekul utama yaitu cincin aromatik kuinolin dan cincin non-aromatik kuinuklidin yang dihubungkan dengan gugus alkohol sekunder pada karbon C-9. Struktur ini banyak mendapat perhatian di  dalam penelitian kimia obat. Kami mempelajari aktivitas biologis yang dimiliki oleh alkaloid kinkona. Alkaloid kikona telah diketahui berfungsi sebagai antimalaria, akantetapi beberapa penelitian terbaru menunjukkan bahwa alkaloid kina memiliki fungsi lain yang berpotensi seperti anti-kanker, anti-tumor, anti-mikroba, anti-HBV, anti-inflamasi, anti-oksidan, anti-obesitas. Ulasan ini menggambarkan kompilasi komprehensif aktivitas biologis berbagai turunan alkaloid kinkona. Kami berharap ulasan artikel ini dapat memberikan kontribusi dalam penyebaran informasi ilmiah terkait kimia medisinal khususnya tentang spektrum aktivitas biologi senyawa turunan alkaloid kinkona.
Dampak Aplikasi Pestisida Sipermetrin, Deltametrin, Klorpirifos dan λ-Sihalotrin Terhadap Kandungan Residu Pestisida pada Biji Kakao
Authors: Fitriadi Bayu Refindra , Putri Ayutia Ciptaningtyas
Published: November 2021

The use of various types of active ingredients with high intensity pesticides in dealing with pest disturbances often makes farmers pay less attention to the negative impacts. Deltamethrin, sipermetrin, λ-cyhalothrin and chlorpyrifos are active ingredients of pesticides that are often used by cocoa farmers to control pests Helopeltis sp. spp. which is one of the main pests in cocoa plants. Field tests on pesticide application were carried out on cocoa plants with Helopeltis sp. spp. High. This test was carried out on 4 treatment blocks applied with different active ingredients. Pesticide residue testing was carried out on cocoa beans, before and after pesticide application using the QuEChERS method on GC-ECD. The results of pesticide residue testing showed that the use of λ-cyhalothrin pesticides did not leave pesticide residues, while sipermetrin pesticides left far fewer pesticide residues compared to deltamethrin and chlorpyrifos pesticides. The results of these pesticide residues are compared to the Pesticide Maximum Residual Limit (MRL) according to the European Commission Part A of Annex I to Reg. 396/2005, shows the results of λ-cyhalothrin and cipermethrin pesticide residues test under pesticide MRL, while the results of deltamethrin and chlorpyrifos pesticide residue test are above the specified pesticide MRL.
Utilization of coconut water as inducing substance in the cultivation of Pleurotus ostreatus
Authors: Elfarisna Elfarisna , Saskiawan Iwan
Published: November 2021

Cultivation of edible mushrooms has been evaluated as an effective way for increasing income of people in developing countries. Pleurotus ostreatus, well known as an oyster mushroom is the most popular edible mushroom in Indonesia. They usually is cultivated using a sawdust as a main substrate. The aim of this research is to reveal the addition of coconut water, the byproduct of traditionally coconut process as an inducing substance in P. ostreatus cultivation.  The results shown that the addition 25% (v/v) of coconut water in substrate of P. ostreatus induce the growth of mycelium. On the other hand, the addition of 50% (v/v) of coconut water affect in the day of fruit body formation become faster as well as increase the number of pileus (stalk)  and  the weight of fruit body.
DAMPAK KEBIJAKAN SUBSIDI PUPUK DAN HARGA PEMBELIAN PEMERINTAH TERHADAP KESEJAHTERAAN PRODUSEN DAN KONSUMEN BERAS DI INDONESIA
Authors: Nauly Dahlia
Published: November 2021

Kebijakan subsidi pupuk merupakan  salah satu kebijakan yang penting di bidang pertanian di Indonesia. Selain itu, kebijakan yang dilakukan oleh pemerintah kebijakan Harga Pembelian Pemerintah (HPP). Kebijakan ini bertujuan ntuk melindungi petani dari jatuhnya harga gabah pada saat panen raya. Tulisan ini mengkaji dampak kebijakan subsidi pupuk dan HPP bagi produsen dan konsumen. Data yang digunakan adalah data time series tahunan dari tahun 1981 sampai 2014 dengan model ekonometrika persamaan simultan. Hasilnya menunjukkan bahwa surplus produsen dan surplus konsumen dipengaruhi oleh kondisi pasar beras domestik. Surplus produsen akan dicapai jika pemerintah menerapkan kebijakan jaminan harga berupa peningkatan Harga Pembelian Pemerintah (HPP), sedangkan surplus konsumen akan dicapai jika pemerintah menerapkan kebijakan peningkatan subsidi input berupa kredit pertanian dan subsidi pupuk serta peningkatan produktivitas areal.  Untuk meningkatan surplus produsen dan konsumen secara merata maka perlu diterapkan paket kebijakan yang merupakan kombinasi dari kebijakan subsidi pupuk dan kebijakan HPP.
PENGARUH PEMBERIAN PUPUK CAIR DAUN KELOR DAN CANGKANG TELUR TERHADAP PERTUMBUHAN SAWI SAMHONG (Brassica juncea L.)
Authors: Suhastyo Arum Asriyanti , Raditya Fanny Tri
Published: November 2021

Growth in mustard greens is greatly influenced by the availability of macro nutrients and micro nutrients, where if the availability of nutrients in the soil is not optimal, fertilization must be carried out. This study aims to examine the effect of the application of liquid organic fertilizer, moringa leaves and eggshells with different concentrations and intervals of fertilizer on the growth of mustard greens. The research design used was a factorial Randomized Block Design, with two factors being tried namely fertilizer application and fertilizer time intervals. First factor: without administration of POC (K0), Moringa leaf POC: eggshell POC 25: 75 ml / l (K1), Moringa leaf POC: eggshell POC 50: 50 ml / l (K2), moringa leaf POC: eggshell POC eggs 75: 25 ml / l (K3). The second factor: the interval of giving F1 fertilizer = 5 days, F2 = 6 days, F3 = 7 days. Each treatment was repeated 3 times to obtain 36 experimental plots. Analysis of the data used to determine the observed response to the treatment given was done by the Analysis of Variance Analysis (ANOVA) and if it showed a real difference followed by Duncan's Multiple Range Test. The conclusion of this study shows that the application of Daunkelor liquid fertilizers and eggshell to the growth of mustard Samhong has not been able to increase plant height, number of leaves and fresh weight of the plan
ANALISIS LINTAS PERTUMBUHAN DAN PRODUKSI TERHADAP PROTEIN KACANG TUNGGAK (Vigna unguiculata L) GENERASI M2
Authors: Wulandari Yukarie Ayu , Sobir Sobir , Aisyah Syarifah Iis
Published: November 2021

Cowpea (V. unguiculata L) can be developed as a source of vegetable protein because it contains relatively high protein and high lysine. The protein content in seeds is an accumulation of character components that play a role in protein formation, whose relationship can be predicted using cross correlation and analysis coefficients. The study was carried out in the experimental garden of Pasir Kuda PKHT of IPB in February - May 2018. Protein analysis is carriedout in the Testing Laboratory of the Department of Agronomy and Horticulture, Faculty of Agriculture, IPB in June - July 2018. The study was conducted using 30 putative mutant test genotypes of M2 generation result from the mutation of gamma ray irradiation and KM4 genotype as a comparison which was repeated three times. The protein content of the seeds was analyzed using the Kjeldahl method and then analyzed the variance, correlation coefficient and path. The results showed that M2 generation putative mutants showed diversity for the character of protein content in cowpea seeds. The protein content in cowpea seeds can be predicted through the character of plant height and number of branches.
Insomnia in Alzheimer’s Disease
Authors:   David Geffen School Of Medicine At UCLA, Roland Joshua
Published: November 2021

Emerging data have suggested lack of sleep as being a possible contributor to the development of Alzheimer’s disease pathology, placing insomnia as a prospective target to positively impact underlying disease progression. Diagnosis and treatment of insomnia can be a challenge in general, with even more complexities occurring in the population of Alzheimer's disease. Treatment data is overall limited. However, multiple non-pharmacological and pharmacological interventions are available for consideration for management
Head Massage Therapy More Efficacious Than Mechanical Helmet Massager to Stimulate Parasympathetic Cardiac Tone: A Randomized Cross-Over Trial
Authors:   Capital Medical University, Guan Ling
Published: November 2021

HMT shows a stronger effect on the parasympathetic nervous system as expressed by increase in HFnu with decrease in HR, diastolic blood pressure and body tension, compared with RR and also MHM. More studies are needed to understand how different relaxing interventions may modulate the autonomic nervous system
ВПЛИВ РИЗИКІВ НА ІНВЕСТИЦІЙНИЙ ПОТЕНЦІАЛ БУДІВЕЛЬНОЇ ГАЛУЗІ
Authors: Polishchuk Yevheniia , Onikienko Serhii
Published: November 2021

Будь-яка підприємницька діяльність перебуває під впливом різноманітних ризиків, настання яких може призвести до зменшення очікуваного прибутку, повної або часткової втрати авансованого капіталу, порушення строків введення в експлуатацію об’єктів будівництва. Зазначимо, що будівельна галузь є однією з найважливіших галузей економіки: вона надає робочі місця, стимулює діяльність видобувних компанії, компаній-виробників будівельних матеріалів, компаній, що надають послуги з операцій із нерухомістю тощо. Це, у свою чергу, дає підстави стверджу-вати, що індустрія будівництва має вагомий внесок у структурі ВВП. Так, в Україні в 2019 році цей показник становив 2,5 % від ВВП, водночас у країнах Європи він сягає 6 %. Такі факти свідчать, що потенціал для росту будівельних компаній є, однак є значні перешкоди, які стримують таке зростання. Інвестиційний потенціал будівельної галузі є важливим. І навіть такий показник, як «Отримання дозволів на будівництво» включений до методології Doing Business від Всесвітнього банку, який вимірює можливості ведення бізнесу в різних країнах. Цей індикатор відображає загальну кількість процедур, час і грошові витрати, необхідні для будівництва складського приміщення, включаючи отримання всіх необхідних ліцензій та дозволів, надання всіх необхідних документів, запит і проходження всіх належних перевірок, а також підключення до інженерних мереж. На додаток до цього, у 2019 році «Ведення бізнесу» вводить новий показник, індекс якості будівельного контролю, який проводить оцінювання: якості регулюючих актів стосуються будівництва, ефективності контролю за якістю і механізмів безпеки, режимів по відповідальності і страхування, а також вимог до рівню професійної кваліфікації. Беручи до уваги той факт, що за декілька років Україна піднялася у цьому рейтингу з 29-го місця (2006 рік) до 6-го (2020 рік), і цей факт можна розглядати як досягнення, проте полегшення отримання дозволів, на жаль, не означає зменшення недобросовісних акторів на ринку, які перетворюють будівельну галузь на високоризиковане середовище.
ОСОБЛИВОСТІ НАДХОДЖЕННЯ ПРЯМИХ ІНОЗЕМНИХ ІНВЕСТИЦІЙ ТА ЇХНІЙ ВПЛИВ НА ЕКОНОМІКУ УКРАЇНИ
Authors: Khomenko Inna , Volynets Lyudmila , Shamkalo Anton
Published: November 2021

У статті визначено особливості інвестиційної діяльності та необхідність залучення суб’єктами господарювання іноземних інвестицій. Проаналізовано тенденції надходження прямих іноземних інвестицій (ПІІ) в Україну. З’ясовано, які галузі та чому залучають найбільше іноземних інвестицій та з огляду на незбалансованість структури інвестицій, визначено питому вагу цих галузей у загальній структурі економіки. Проведено аналіз діяльності українських стартапів, що залучили найбільше ПІІ в 2020 році та спрогнозовано майбутній розвиток компаній. Проаналізовано положення України серед країн світу за легкістю ведення бізнесу та визначити перешкоди, що стають на заваді підняття в рейтингу «DOING BUSINESS». Оцінено передумови створення вільних економічних зон. Розкрито поняття «офшор» та визначено яким чином в Україні проводиться політика проти «відмиванням коштів». Визначено негативні фактори, які є чинниками погіршення інвестиційного клімату та в довгостроковій перспективі є перешкодами до зростання обсягів інвестування. Запропоновано та обґрунтовано потенційні шляхи покращення інвестиційного клімату України на основі світового досвіду.
КОНЦЕПТУАЛЬНІ ЗАСАДИ НАВЧАННЯ ПЕРСОНАЛУ В УМОВАХ ДІДЖИТАЛ-ТРАНСФОРМАЦІЇ БІЗНЕСУ
Authors: Remnova Lyudmyla , Zabashtanska Tatiana
Published: November 2021

У статті проаналізовано логічну послідовність впровадження цифрових технологій у бізнес-процеси компаній та виявлено вплив еволюційного ланцюга «діджитизація – діджиталізація – діджитал-трансформація» на появу нових викликів у сфері корпоративної освіти. Обґрунтовано принципи формування сучасної моделі корпоративної освіти та критерії вибору інноваційних форм навчання персоналу відповідно до вимог цифрового середовища з урахуванням стрімкого розвитку ринку освітніх послуг під час глобальної пандемії COVID-19.
Zeolite — natural ameliorant for dry meadow polluted by caesium-137
Authors: Романенко А.А. , Мирзоев Э.Б. , Исамов Н.Н.
Published: November 2021

Исследовательская работа выполнена в Новозыбковском районе Брянской области на естественном суходольном лугу, подвергшемся радиоактивному загрязнению в результате аварии на Чернобыльской АЭС. Загрязнение территории радиоактивными веществами, возникшее в результате чернобыльской катастрофы, создало целый ряд проблем для ведения сельскохозяйственного производства. Одной из них является проблема использования естественных луговых экосистем, загрязнённых цезием-137, в качестве сенокосов и пастбищ. Травостой естественных лугов накапливает радионуклида больше, чем травостой, выращенный на обработанной сельхозорудиями почве. В этой связи поиск доступных, эффективных и экономически выгодных мер, позволяющих получать на естественных лугах продукцию, соответствующую нормативным показателям, имеет важное значение. Целью исследовательской работы было изучение влияния цеолита Хотынецкого месторождения на переход радионуклида из почвы в растение на естественном суходольном лугу. Для этого в августе на поверхность почвы опытных делянок вносили цеолит в объёме 0,5 и 1% от массы пахотного слоя. Через год отбирали сопряжённые пробы почвы и растений. После подготовки в них определяли концентрацию цезия-137, а также агрохимические, физико-химические показатели почвы и урожайность. В ходе выполнения исследовательской работы было установлено, что использование цеолита в качестве мелиоранта луга не оказало достоверного влияния на снижение радионуклида в травостое (сене) и на увеличение Hr, S, EKO, V, калия и фосфора. Однако достоверно увеличился показатель рН. Внесение цеолита на опытные делянки в количестве 0,5 и 1% от массы пахотного слоя почвы оказало выраженное положительное влияние на урожайность сена.

The investigation took place in the Bryansk region. The territory of natural dry meadow was contaminated there due to the Chernobyl disaster. Radioactive contamination significantly impacts agriculture in the area. Caesium-137 presented in soil hinders hay and green forage production. Natural plant ecosystems accumulate more radionuclide than the ones grown on farm fields. Therefore, those methods are of the highest interest that allow production of healthy forage in that area. The aim of the research was to analyze the effect of the zeolite from the Khotynetskiy district on the radionuclide movement from soil to plants. In August the zeolite (0.5 and 1% of soil mass) was applied in soil. One year later soil and plant samples were tested for caesium-137 as well as agrochemical, physical, chemical properties and productivity. As a result, the zeolite had no significant impact on the accumulation of caesium-137 in hay as well as Hr, S, EKO, V, K or P. In contrast, рН grew significantly and hay yield increased.
METHODOLOGICAL APPROACH TO THE CREATION OF ENRICHED FUNCTIONAL FOODS
Authors: Викторова Е.П. , Калманович С.А. , Корнен Н.Н. , Шахрай Т.А.
Published: November 2021

Предложен методологический подход к созданию обогащенных функциональных пищевых продуктов, который включает шесть основных этапов и предусматривает на каждом этапе реализацию нескольких конкретных подэтапов. Такой методологический подход к созданию обогащенных функциональных пищевых продуктов позволяет аргументированно и обоснованно выбирать основной объект – базовый пищевой продукт, биологически активные или пищевые добавки для обогащения, а также гарантирует получение готового продукта, отвечающего комплексу требований, предъявляемых к обогащенным функциональным пищевым продуктам.

The methodological approach to the creation of fortified functional foods, which includes six main stages and provides for the implementation of several specific sub-stages at each stage, is proposed. This methodological approach to the creation of enriched functional foods allows reasoned and reasonable choice of the main object-the basic food product, biologically active or food additives for enrichment, as well as ensures the production of the finished product that meets the complex requirements for enriched functional foods.
PHYSICAL AND CHEMICAL BASES OF PROCESS OF EXTRACTION OF PECTINACEOUS SUBSTANCES OF APPLE RAW MATERIALS
Authors: ДОНЧЕНКО Л.В. , КРАСНОСЕЛОВА Е.А.
Published: November 2021

Статья посвящена актуальной задаче – разработке физико-химических основ процесса извлечения пектиновых веществ из яблочного сырья. На основе анализа результатов теоретических и экспериментальных исследований изучены основные технологические факторы, влияющие на эффективность процесса извлечения пектина из одного из основных видов растительного сырья – яблочных выжимок. Предложено рассматривать извлечение пектина как процесс, состоящий из трех основных стадий: подготовки сырья к гидролизу протопектина, гидролиза и экстрагирования гидратопектина. Установлены технологические требования и факторы для каждой технологической стадии процесса. Определен основной кинетический коэффициент процесса – коэффициент диффузии пектиновых веществ D. В результате улучшения массообменных условий при проведении процесса извлечения пектиновых веществ из растительного сырья увеличен выход целевого вещества из единицы перерабатываемого промышленного сырья.

Article is devoted to a relevant task – development of physical and chemical bases of process of extraction of pectin substances of apple raw materials. On the basis of the analysis of results of theoretical and pilot studies the major technology factors influencing efficiency of process of extraction of pectin of one of main types of vegetable raw materials – an apple pomace are studied. It is offered to consider pectin extraction as the process consisting of three main stages: preparation of raw materials for hydrolysis of protopectin, hydrolysis and extraction of a gidratopektin. Technological requirements and factors for each technological stage of the process are established. The main kinetic coefficient of process – coefficient of diffusion of pectin substances D is has been defined. As a result of improvement of mass exchanged conditions when carrying out process of extraction of pectinaceous substances of vegetable raw materials an exit of target substance from unit of the processed industrial raw materials is increased.
ESTIMATION OF EFFICIENCY OF IMPLEMENTATION OF METHOD 5S ORGANIZING AT THE ENTERPRISE OF PUBLIC CATERING
Authors: ШАБАЛИНА С.Г. , ДВАДНЕНКО М.В. , ФРАНЧЕНКО Е.С. , КЛИМЕНКО И.Н.
Published: November 2021

Проведена оценка эффективности применения метода 5S Упорядочение на предприятии общественного питания ООО «Комсомол» сети ресторанов «Рис». Установлено, что основные экономические потери относятся к потерям рабочего времени. Выбор целевой зоны для применения 5S показал узкое место организации – работу бара. В целевой зоне провели хронометраж и сравнили полученные данные с утвержденными стандартами обслуживания. Основные затраты времени были связаны с поиском компонентов и приготовлением заказов. Для снижения потерь времени провели сканирование рабочего места бармена на соответствие требованиям 5S. Составлен диагностический контрольный лист первичного сканирования. Оценку ситуации провели по рейтинговой пятибалльной шкале, общий балл рейтинга – 31, максимальный балл при оценке по принятой шкале – 48. Выявлены основные направления повышения эффективности работы предприятия: рациональное расположение предметов в рабочей зоне, уборка, стандартизация. Применение метода 5S в баре позволило сократить затраты времени на выполнение заказов на 22%. Экономический эффект от увеличения выручки предприятия за счет экономии рабочего времени составил 6,2%. Применение метода 5S Упорядочение в ресторане позволило без значительных материальных затрат повысить производительность труда на производстве и в контактной зоне за счет снижения потерь времени, исключения лишних движений и перемещений, совершенствования рабочего пространства.

Assessment of efficiency of application of a method 5S Organizing at the enterprise of a public catering LLC Komsomol of network of restaurants Rice is given. It is established that the main economic losses relate to the loss of working time. The choice of a target zone for application 5S has shown a bottleneck of the organization – work of bar. In a target zone have carried out timing and have compared data with the approved standards of service. The main expenses of time have been connected with search of components and preparation of orders. The control leaf of primary scanning of a workplace of the bartender is made. Assessment of the situation was carried out on a rating five-point scale, the general point of rating – 31, the maximum point at assessment on the accepted scale – 48. The main directions of increasing the efficiency of the enterprise are identified: the rational arrangement of objects in the work area, cleaning, standardization. Application of a method 5S in bar has allowed to reduce expenses of time for implementation of orders for 22%. Economic effect of increase in revenue of the enterprise due to economy of working hours was 6,2%. Application of a method 5S at restaurant has allowed to increase without considerable material inputs labor productivity on production and in a contact zone due to reduction of losses of time, an exception of excess movements and internal displacements, improvement of working space.
RESEARCH OF CONSUMER PROPERTIES OF FUNCTIONAL BAKERY PRODUCTS ENRICHED WITH FRUIT POLYSACCHARIDE-VITAMIN DIETARY SUPPLEMENT
Authors: КОРНЕН Н.Н. , КАЛМАНОВИЧ С.А. , ШАХРАЙ Т.А. , ВЕРШИНИНА О.Л. , ВИКТОРОВА Е.П. , МАТВИЕНКО А.Н.
Published: November 2021

Разработаны рецептуры хлебобулочных изделий, обогащенных фруктовой полисахаридно-витаминной пищевой добавкой «Порошок яблочный». Разработанные изделия имеют более высокие показатели: пористость мякиша хлеба и булки 79 и 80%, удельный объем 390 и 410 см3/100 г соответственно по сравнению с контрольными образцами (70 и 73%, 310 и 330 см3/100 г соответственно). Формоустойчивость подового изделия обогащенного хлеба (0,55 H/D) и булки (0,60 H/D) также выше контрольных образцов – 0,40 и 0,42 H/D соответственно. Кроме того, в отличие от контрольных образцов хлебобулочных изделий, в которых отсутствуют пектин и Р-активные вещества, в составе разработанных хлеба и булки пектина содержится 0,22 и 0,25 г/100 г соответственно, Р-активных веществ 53,64 и 54,85 мг/100 г соответственно. Внесение пищевой добавки на стадии брожения опары сократило продолжительность технологического процесса производства хлеба и булки на 70 и 80 мин соответственно. Установлено, что разработанные хлебобулочные изделия соответствуют требованиям ТР ТС 021/2011 по показателям безопасности и являются функциональными, так как потребление их в количестве 250 г в сутки позволяет удовлетворить более 15% рекомендуемой физиологической нормы в ряде пищевых функциональных ингредиентов, таких как пищевые волокна, пектин, Р-активные вещества, калий и медь.

Formulations of bakery products enriched with fruit polysaccharide-vitamin food supplement Apple Powder have been developed. The developed products have higher rates: porosity of bread crumb and rolls 79 and 80%, specific volume 390 and 410 cm3/100 g, respectively, compared to control samples (70 and 73%, 310 and 330 cm3/100 g, respectively). The form stability of the hearth product of enriched bread (0,55 H/D) and bun (0,60 H/D) is also higher than the control samples – 0,40 and 0,42 H/D, respectively. In the bread composition and bun contain 0,22 and 0,25 g/100 g pectin, P-active substances 53,64 and 54,85 mg/100 g, respectively. The introduction of a food additive at the fermentation stage of the sponge reduced the duration of the technological process of production of bread and bun by 70 and 80 minutes, respectively. It is established that the developed bakery products in terms of safety meet the requirements of TR CU 021/2011. The developed bakery products are functional, since their consumption in the amount of 250 g per day satisfies more than 15% of the recommended physiological norm in a number of food functional ingredients, such as dietary fibers, pectin, P-active substances, potassium and copper.
Day-Case Patent Foramen Ovale Closure Under Transthoracic Echocardiography and Fluoroscopic Guidance: A Safe and Cost-Effective Approach as Compared to Conventional Hospitalization
Authors:   Department of Pediatric Cardiology and Congenital Heart Disease, Institut Coeur Poumon, CHU Lille, France, F Godart , B Baudelet J ,   Department of Pediatric Cardiology and Congenital Heart Disease, Institut Coeur Poumon, CHU Lille, France, O Chatillon-Domanski ,   Department of Pediatric Cardiology and Congenital Heart Disease, Institut Coeur Poumon, CHU Lille, France, S Polge A ,   Department of Clinical Physiology and Echocardiography. Institut Coeur Poumon, CHU Lille, France, A Houeijeh ,   Department of Pediatric Cardiology and Congenital Heart Disease, Institut Coeur Poumon, CHU Lille, France
Published: November 2021

Background: Transcatheter Patent Foramen Ovale (PFO) is recommended as a therapy in secondary prevention of cryptogenic stroke. The aim of this study was to report one-year French single-center experience in PFO closure under sole Transthoracic Echocardiography (TTE) and fluoroscopy guidance performed as a day-case procedure versus a 3-day hospitalization. Methods: In 2018, all consecutive patients undergoing PFO closure for stroke were retrospectively included: 108 patients as a day-case procedure (group 1) versus 20 patients performed under a 3-day hospitalization (group 2). A comparison was performed between Occlutech and Amplatzer PFO devices and the impact on hospitalization costs was studied. Results: Occluders included Occlutech (n=81), Amplatzer (n=43), Lifetech (n=2) and PFM (n=2) PFO devices. Implantation succeeded in all. In-group 1, hospital discharge was delayed in only 3 cases. At one-month, 5 patients had Atrial Fibrillation (AF) and 91 patients (84%) had no residual shunt. In-group 2, hospital discharge was delayed in 4 patients. At one month, 1 patient had AF and no shunt was observed in 80%. In the comparative study, no significant statistical difference could be observed between Amplatzer and Occlutech devices. The one-day strategy leaded to a positive balance of 1825 euros per procedure in 2018, with a difference of 3785 euros with group 2. Conclusion: Our experience suggests that day-case PFO closure under fluoroscopy and TTE guidance is safe and effective in the majority of patients leading to a cost reduction and no increased risk of embolization.
Association between Homocysteine-Related Dietary Patterns and Gestational Diabetes Mellitus: A Study Using the Reduced Rank Regression Method
Authors:   Department of Nutrition, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China, W Hui , L Yu-Hong ,   Department of Obstetrics and Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China, L Ling-Peng ,   Department of Clinical Lab, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China, Y Min-Hui ,   Department of Obstetrics and Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China, W Siyu ,   Department of Nutrition, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China, L Gu-Qin ,   Department of Nutrition, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China, S Chun-Yan ,   Department of Nutrition, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China
Published: November 2021

Background: This study aimed to evaluate the association between homocysteine-related dietary patterns and gestational diabetes mellitus. Methods: A total of 488 pregnant women at 24-28 weeks of gestation between January 2019 and December 2020 were included. Demographic characteristics, dietary intake, and multivitamin supplement intake information were collected using a food frequency questionnaire (FFQ); fasting venous blood samples were collected for serum index detection. Serum homocysteine (Hcy), folic acid, and B12 were selected as response variables, and hyperhomocysteinemia (hHcy)- related dietary patterns were extracted using the descending rank regression method. The relationship between the score of hHcy-related dietary patterns and GDM was analyzed using a multivariate logistic regression model. Results: Three hHcy-related dietary patterns were extracted: (mode 1) more meat, cattle meat intake, green leafy vegetables, dark vegetables and soy, and less consumption of shrimp. (mode 2) livestock meat, eggs and more grains, green leafy vegetables, bacteria, algae, dairy, and less nuts intake; and (model 3) livestock meat intake, and less soy intake. Because the explanatory variation of mode 3 was relatively small, it was not retained. Only mode 2 had a positive and significant relationship with the risk of developing GDM. After adjusting for confounding factors, the risk of GDM was significantly increased in the highest quartile array (OR=2.96, 95% Confidence Interval: 0.939-9.356, P=0.004). There was no significant correlation between dietary pattern 1 and GDM risk (P >0.05).
Review on Epidemiology, Control and Public Health Importance of Bovine Fasciolosis
Authors:   Department of Tropical Veterinary Parasitology and Pathology, Addis Ababa University, Bishoftu, Ethiopia, TT Feyisa
Published: November 2021

Fascioliasis is a trematode zoonotic snail-borne disease of public health and economic importance. Fasciolosis is a parasitic disease that affects most population of cattle and it exists in almost all parts of the world. It is caused by commonly known species of liver fluke that are Fasciola hepatica and Fasciola gigantica, which mainly affects domestic ruminants. Fasciolosis is more apparent in young cattle and is usually chronic in nature. Adult flukes in the bile ducts cause inflammation, biliary obstruction, distraction of liver tissue and anemia. Fasciolosis is the major burden for Animal production and by direct or indirect economic losses at different part of our country. Diagnosis of fasciolosis is based primarily on clinical signs and seasonal occurrence in endemic areas but previous history of fasciolosis on the farm or identification of snail habitats; postmortem examinations, hematological tests and examination of faeces for fluke eggs are useful. The life cycle of Fasciola spp. is a typical of digenetic treamatodes. Eggs laid by the adult parasite in the bile ducts of their hosts pass into the duodenum with the bile. The life cycle of Fasciola goes through the intermediate host and several developmental stages in the intermediate host. On a herd basis, clinical signs of fluke infection are usually vague (i.e., reduced productivity) and can be difficult to differentiate from the effects of less-thanoptimal management or other chronic disease conditions. Transmission of fasciolosis infection is depending on the presence of “lymnea snail”, host and final host. Among many parasitic problems of farm animals, fasciolosis is a major disease which imposes economic impact on livestock production particularly of cattle and sheep and it has public health importance as it have zoonotic value.
The magnetic stir bar as a source of impurities in laboratory blank solutions of the environmental samples subjected to microwave-assisted acid digestion
Authors: Rosen Vasiliy , Andrushchenko Yuliana , Zelinger Einat , Gal Garber Orit
Published: November 2021

Teflon-coated magnetic stir bars are suspected to be a source of impurities for the laboratory blank solutions. To evaluate the ability of magnetic bars to absorb and release different elements at sub-ppb and above-ppb (µg L-1) level the experiment with new and used bars was conducted. The bars were subjected to microwave-assisted acid digestion with the soil sample and a series of successive cleaning procedures. The ICP-OES/MS analysis of the obtained extracts revealed that most of the elements may be released during subsequent extractions in the ppb-level concentrations, whereas the following elements: Cr, Cu, Sb, Sn, and Pb may be extracted even in elevated concentrations. SEM/EDS inspection of Teflon surfaces demonstrated the multiple defects that probably increase the absorption of the elements. We concluded that the concentration of mineral impurities in the laboratory blank solution prepared in the randomly selected one vessel per sample preparation batch is hardly propagated to the other used vessels. The alternative concept "blank per vessel" was proposed especially for ultra-trace analysis. Also, an additional step in the bar washing procedure was proposed.
Explainable Graph Neural Networks for Organic Cages
Authors: Yuan Qi , Szczypiński Filip , Jelfs Kim
Published: November 2021

The development of accurate and explicable machine learning models to predict the properties of topologically complex systems is a challenge in material science. Porous organic cages, a class of polycyclic molecular materials, have potential application in molecular separations, catalysis and encapsulation. For most applications of porous organic cages, having a permanent internal cavity in the absence of solvent, a property termed “shape persistency” is critical. Here, we report the development of Graph Neural Networks (GNNs) to predict the shape persistence of organic cages. Graph neural networks are a class of neural networks where the data, in our case that of organic cages, are represented by graphs. The performance of the GNN models was measured against a previously reported computational database of organic cages formed through a range of [4+6] reactions with a variety of reaction chemistries. The reported GNNs have an improved prediction accuracy and transferability compared to random forest predictions. Apart from the improvement in predictive power, we explored the explicability of the GNNs by computing the integrated gradient of the GNN input. The contribution of monomers and molecular fragments to the shape persistence of the organic cages could be quantitatively evaluated with integrated gradient. With the added explicability of the GNNs, it is possible not only to accurately predict the property of organic materials, but also to interpret the predictions of the deep learning models and provide structural insights to the discovery of future materials.
Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulse
Authors: Svenningsen Mikkel Skjoldan , Svenningsen Sine Lo , Sørensen Michael Askvad , Mitarai Namiko
Published: November 2021

The vast majority of a bacterial population is killed when treated with a lethal concentration of antibiotics. The time scale of this killing is often comparable with the bacterial generation time before the addition of antibiotics. Yet, a small subpopulation typically survives for an extended period. However, the long-term killing dynamics of bacterial cells has not been fully quantified even in well-controlled laboratory conditions. We constructed a week-long killing assay and followed the survival fraction of Escherichia coli K12 exposed to a high concentration of ciprofloxacin. We found that long-term survivors were formed during exponential growth, with some cells surviving at least 7 d. The long-term dynamics contained at least three time scales, which greatly enhances predictions of the population survival time compared with the biphasic extrapolation from the short-term behavior. Furthermore, we observed a long memory effect of a brief starvation pulse, which was dependent on the (p)ppGpp synthase relA. Specifically, 1 h of carbon starvation before antibiotics exposure increased the surviving fraction by nearly 100-fold even after 4 d of ciprofloxacin treatment.