bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental sensitivity increases susceptibility to resilient contexts in adults with childhood experiences of neglect
Authors: Di Paola Ludovica , Nocentini Annalaura , Lionetti Francesca
Published: November 2022

Empirical evidence regarding the impact of childhood emotional neglect on later adjustment is mixed, with some studies reporting neglect to predict low psychological well-being, while others reporting a well-adjusted development despite childhood experiences of emotional neglect. This heterogeneity is understood within a resilient framework where individual and contextual factors act as moderators. This is the first study investigating the moderating role of environmental sensitivity and contextual resilience on the association between childhood emotional neglect and psychological well-being.737 students from the University of Florence with an age ranging from 18 to 30 years (M = 19.81; SD = 1.91; 87% female) took part in the research. To investigate the effects of childhood emotional neglect on relational well-being, and the moderating role of environmental sensitivity and contextual resilience on the impact of emotional neglect, a series of generalized linear models, including only main effects and then adding interaction terms, were run and compared. Results provided support for a three-way interaction model, with environmental sensitivity and contextual resilience moderating the impact of childhood emotional neglect on relational well-being in young adulthood (B = .37, SE = .11, p < .001). Among those who experienced severe levels of childhood emotional neglect, young adults high in environmental sensitivity were more susceptible to the positive impact of supportive contexts, presenting higher levels of well-being compared to those low in environmental sensitivity. This study suggests that promoting supportive contexts in adulthood might reduce the impact of severe childhood emotional neglect, particularly in individuals with an increased environmental sensitivity.
Determination of Optimum Zn Content for Mg–xZn–0.5Mn–0.5Sr Alloy in Terms of Mechanical Properties and In Vitro Corrosion Resistance
Authors: Suh Joung Sik , Ha Heon-Young , Suh Byeong-Chan , Kang Jae-Wook
Published: November 2022

This study investigated the microstructure, compressive properties and in vitro corrosion behavior of biodegradable Mg–xZn–0.5Mn–0.5Sr (ZMJ) alloy with Zn content of 0 to 5 wt% in the as-cast state. Increasing the Zn content in ZMJ alloy refined the grains from 215 to 95 µm and changed the secondary particles from Mg17Sr2 to Mg6Zn2Sr and MgZn phases. As the Zn content increased, the compressive yield strength increased from 44 to 67 MPa due to grain boundary strengthening. At immersion in phosphate-buffered saline for 7 days, the addition of Zn from 0 to 0.1 wt% reduced the corrosion rate from 0.71 to 0.48 mm/y, and 0.85 wt% Zn was alloyed to obtain the lowest corrosion rate of 0.45 mm/y. However, adding more Zn significantly increased the corrosion rate up to 3.31 mm/y. Thus, the best anti-corrosion performance can be obtained at 0.85 wt% Zn, which was attributed to its lowest Volta potential difference between the main secondary particles and the α-Mg matrix among ZMJ alloy. Based on this, the optimal Zn content for ZMJ alloy can be determined to be about 1 wt% by comprehensively considering the mechanical properties and in vitro corrosion behavior for biomedical applications.

Graphical abstract

Micrographs of (a,c) the specimen as-built in vertical direction (Type I) and (b,d) the specimen as-built in horizontal direction (Type II) to the building platform.
Is government funding critical to the operating performance of technology universities? A case study of Taiwan
Authors: He Dong-Sing , Tebourbi Imen
Published: November 2022

This study utilizes the Malmquist Productivity Index (MPI) to evaluate the operating performance of technology universities in Taiwan. The bootstrap method is employed to analyze MPI sensitivity to verify the index’s stability. Our results suggest that the universities demonstrate an adequate level of performance with little improvement required. Technology universities with a greater proportion of total income from government subsidies did not evidence better operating performance. We argue that how universities obtain their funding is critical. Our findings will help universities (and their relevant departments) improve performance and better allocate resources.
Overcoming the Technical Challenges of Total Knee Arthroplasty in Patients Affected by Hereditary Multiple Exostoses: a Case Report and Literature Review
Authors: Cammisa Eugenio , Alesi Domenico , Meena Amit , Lullini Giada , Zaffagnini Stefano , Marcheggiani Muccioli Giulio Maria
Published: November 2022

Hereditary multiple exostoses (HME), also known as familiar osteochondromatosis or diaphyseal aclasis, are an autosomal dominant inherited genetic pathology that is characterized by the presence of multiple benign osteochondromas. Knee deformity is common in patients with HME, with nearly a third of patients developing genu valgus. Total knee arthroplasty (TKA) has been used to correct valgus deformities with advanced knee osteoarthritis (OA). However, concomitant limb deformities and altered anatomy of the knee make this surgery particularly challenging. We present a case report and a mini-review of the literature on this topic. We present the case of a 50-year-old Caucasian woman, affected by hereditary multiple exostoses, who came to our attention for progressive pain in the right knee. Upon further examination, the knee had a prominent valgus alignment, concomitant valgus instability, and flexion contraction. The patient was treated with total knee arthroplasty using a semi-constrained design. The patient was re-evaluated at 24-month follow-up, and there were no signs of implant loosening, the knee function improved significantly, and the patient was very satisfied. Given the recurring technical difficulties of such procedure in these patients, we describe our experience as well as the need for preoperative planning, the use of appropriate constraint when required, the high frequency of ligament instability, bony defects, and patellar maltracking. TKA must be considered when necessary, in these patients, as good to excellent clinical results can be achieved and maintained, allowing for significant improvements in quality of life.

Core Tips

- TKA in HME-affected patients carries specific but manageable challenges.

- Due to bone deformities and frequent severe valgus knee alignment, TKA should be considered even in younger patients.

- Revision implants provide the flexibility and the necessary fixation, not always achievable with primary implants.

- Bigger size components may be necessary in HME patients compared with patients of the same height.

- Lateral ligament releases may often be necessary due to long-standing valgus deformity. If stability cannot be achieved, the use of a hinged implant should be considered.

- Cementation of the metaphysis or the use of sleeves can provide additional rotational stability to the implant.
Aquinas on Efficient Causation and Causal Powers
Authors: Frost Gloria
Published: November 2022

In this innovative book, Gloria Frost reconstructs and analyses Aquinas's theories on efficient causation and causal powers, focusing specifically on natural causal powers and efficient causation in nature. Frost presents each element of Aquinas's theories one by one, comparing them with other theories, as well as examining the philosophical and interpretive ambiguities in Aquinas's thought and proposing fresh solutions to conceptual difficulties. Her discussion includes explanations of Aquinas's technical scholastic terminology in jargon-free prose, as well as background on medieval scientific views - including ordinary language explanations of the medieval physical theories which Aquinas assumed in formulating his views on causation and causal powers. The resulting volume is a rich exploration of a central philosophical topic in medieval philosophy and beyond, and will be valuable especially for scholars and advanced students working on Aquinas and on medieval natural philosophy.
Kongish
Authors: Lee Tong King
Published: November 2022

This Element introduces Kongish as a translingual and multimodal urban dialect emerging in Hong Kong in recent years and still in the making. Through the lens of translanguaging and linguistic commodification, and using the popular Facebook page Kongish Daily as a case in point, the study outlines the semiotic profile of Kongish. It examines how Kongish communications draw on a full range of performative resources, thriving on social media affordances and a creative-critical ethos. The study then turns to look at how Kongish is commoditized in a marketing context in the form of playful epithets emplaced on locally designed products, demonstrating how the urban dialect is not merely a niche medium of communication on social media, but has become integral to commercial, profit-driven practices. The Element concludes by challenging the proposition that Kongish must be considered a 'variety' of English, arguing instead that it is an innominate term embodying translanguaging-in-action.
Essence
Authors: Glazier Martin
Published: November 2022

This Element examines the contemporary literature on essence in connection with the traditional question whether essence lies within or without our world. Section 1 understands this question in terms of a certain distinction, the distinction between active and latent facts. Section 2 steps back to investigate the connections between essence and other philosophical concepts. Section 3 brings the results of this investigation to bear on the traditional question, sketching an argument from the premise that essentialist facts are explained by the origins of things to the conclusion that such facts are active.
Navigating the Realities of Metaphor and Psychotherapy Research
Authors: Tay Dennis
Published: November 2022

The 'real-world' commitment of cognitive linguistics is demonstrated by increasingly extensive collaboration between researchers and industry partners. Yet, there has been little critical reflection on the lessons learnt from these collaborative efforts. Beginning researchers may benefit from in-depth discussion of how various practical realities inform, constrain, or otherwise shape important methodological and/or analytic decisions. This Element reflects on long-term collaborative work between a metaphor researcher and psychotherapists, offering practical advice on navigating the latent realities of this type of research. The three foundational components of psychotherapy – the therapist, the client, and the interactional setting itself – are discussed in turn, covering issues like ethically engaging therapists in research design and data analysis, dealing with underexplored variabilities in client responses, and managing the inherent tension between spontaneity and control in an interactional setting like psychotherapy. Some thoughts on how the lessons are transferable to other research contexts are offered.
Statistical mechanics in climate emulation: Challenges and perspectives
Authors: Sudakow Ivan , Pokojovy Michael , Lyakhov Dmitry
Published: November 2022

Climate emulators are a powerful instrument for climate modeling, especially in terms of reducing the computational load for simulating spatiotemporal processes associated with climate systems. The most important type of emulators are statistical emulators trained on the output of an ensemble of simulations from various climate models. However, such emulators oftentimes fail to capture the “physics” of a system that can be detrimental for unveiling critical processes that lead to climate tipping points. Historically, statistical mechanics emerged as a tool to resolve the constraints on physics using statistics. We discuss how climate emulators rooted in statistical mechanics and machine learning can give rise to new climate models that are more reliable and require less observational and computational resources. Our goal is to stimulate discussion on how statistical climate emulators can further be improved with the help of statistical mechanics which, in turn, may reignite the interest of statistical community in statistical mechanics of complex systems.
Multilayer dielectric grating pillar-removal damage induced by a picosecond laser
Authors: Shuai Kun , Liu Xiaofeng , Zhao Yuanan , Qiu Keqiang , Li Dawei , Gong He , Sun Jian , Zhou Li , Jiang Youen , Dai Yaping , Shao Jianda , Xia Zhilin
Published: November 2022

Multilayer dielectric gratings typically remove multiple-grating pillars after picosecond laser irradiation; however, the dynamic formation process of the removal is still unclear. In this study, the damage morphologies of multilayer dielectric gratings induced by an 8.6-ps laser pulse were closely examined. The damage included the removal of a single grating pillar and consecutive adjacent grating pillars and did not involve the destruction of the internal high-reflection mirror structure. Comparative analysis of the two damage morphological characteristics indicated the removal of adjacent pillars was related to an impact process caused by the eruption of localized materials from the left-hand pillar, exerting impact pressure on its adjacent pillars and eventually resulting in multiple pillar removal. A finite-element strain model was used to calculate the stress distribution of the grating after impact. According to the electric field distribution, the eruptive pressure of the dielectric materials after ionization was also simulated. The results suggest that the eruptive pressure resulted in a stress concentration at the root of the adjacent pillar that was sufficient to cause damage, corresponding to the experimental removal of the adjacent pillar from the root. This study provides further understanding of the laser-induced damage behavior of grating pillars and some insights into reducing the undesirable damage process for practical applications.
New solutions for interfacial capillary waves of permanent form
Authors: Guan X. , Vanden-Broeck J.-M. , Wang Z.
Published: November 2022

Progressive capillary waves on the interface between two homogeneous fluids confined in a channel with rigid walls parallel to the undisturbed interface are investigated. This problem is formulated as a system of integrodifferential equations that can be solved numerically via a boundary integral equation method coupled with series expansions of the unknown functions. With this highly accurate scheme and numerical continuation, we explore the global bifurcation of periodic travelling waves. It is found that there are two types of limiting profile, self-intersecting and boundary-touching, which appear either along a primary branch bifurcating from infinitesimal periodic waves or on an isolated branch existing above a certain finite amplitude. For particular sets of parameters, these two types of bifurcation curves can intersect, which can be viewed as a secondary bifurcation phenomenon occurring on the primary branch. Based on asymptotic and numerical analyses of the almost limiting waves, it is found that the boundary-touching solutions feature a circular geometry, i.e. the interface is pieced together by circular arcs of the same radius. A theoretical investigation yields the necessary conditions for the existence of these extreme waves, whereby we can predict the limiting configurations for most parameter sets. The comparisons between theoretical predictions and numerical results show good agreement.
An elementary approach to component sizes in critical random graphs
Authors: De Ambroggio Umberto
Published: November 2022

In this article we introduce a simple tool to derive polynomial upper bounds for the probability of observing unusually large maximal components in some models of random graphs when considered at criticality. Specifically, we apply our method to a model of a random intersection graph, a random graph obtained through p-bond percolation on a general d-regular graph, and a model of an inhomogeneous random graph.
“From Ordaining Women to Combating White Supremacy: Oppositional Shifts in Social Attitudes between the Southern Baptist Convention and the Alliance of Baptists”
Authors: Gardner Andrew , Martí Gerardo
Published: November 2022

From its founding in 1987, the Alliance of Baptists’ stance on women in ministry served as the nexus point from which the small denominational body departed from its denominational forebears in the Southern Baptist Convention. As the Alliance adopted more and more progressive theological and social ideas, Southern Baptists adopted more and more conservative counterpoints, at times in response to each other. In 2021, the divergence of these two bodies came to the fore. As members of the Alliance of Baptists adopted a new covenant statement committing the denomination to “act to dismantle systems of white supremacy, patriarchy, and abusive power,” the Southern Baptists had walked away from working through their pro-slavery past and were agitating against critical race theory. Theological moves that began in a debate over women's ordination morphed into larger shifts that redefined what it meant to be a Baptist in the modern United States. How both denominational bodies came to embrace different systems of authority and governance in the late 1980s set both groups on divergent paths, leading to strikingly antithetical positions not only on issues of gender but also on issues surrounding race. The contrast further affirms that questions of gender and religious authority and questions of racism and white supremacy within denominational contexts are not isolated, separate questions but rather are deeply intertwined and related to one another. Overall, this SBC–Alliance history demonstrates how denominational bodies actively consider proximate organizations as they develop their own policies, processes, and public proclamations.
ON A CONJECTURE CONCERNING THE NUMBER OF SOLUTIONS TO
Authors: LE MAOHUA , STYER ROBERT
Published: November 2022

Let a, b, c be fixed coprime positive integers with
$\min \{ a,b,c \}>1$
. Let
$N(a,b,c)$
denote the number of positive integer solutions
$(x,y,z)$
of the equation
$a^x + b^y = c^z$
. We show that if
$(a,b,c)$
is a triple of distinct primes for which
$N(a,b,c)>1$
and
$(a,b,c)$
is not one of the six known such triples, then
$c>10^{18}$
, and there are exactly two solutions
$(x_1, y_1, z_1)$
,
$(x_2, y_2, z_2)$
with
$2 \mid x_1$
,
$2 \mid y_1$
,
$z_1=1$
,
$2 \nmid y_2$
,
$z_2>1$
, and, taking
$a<b$
, we must have
$a=2$
,
$b \equiv 1 \bmod 12$
,
$c \equiv 5\, \mod 12$
, with
$(a,b,c)$
satisfying further strong restrictions. These results support a conjecture put forward by Scott and Styer [‘Number of solutions to
$a^x + b^y = c^z$
’, Publ. Math. Debrecen88 (2016), 131–138].
Related Investing: Family Networks, Gender, and Shareholding in Antebellum New England Corporations
Authors: Khan B. Zorina
Published: November 2022

Research into the organization of the firm typically contrasts family businesses with impersonal corporate structures, and kinship ties among corporate elites are often associated with inefficiency and corruption. This analysis of over 14,000 equity investors and executive officers finds that familial networks were embedded in early corporations, not just among directors but also among small shareholders in the firm. Related investing was especially prominent among women and other relatively disadvantaged groups. Personal ties in newer, riskier enterprises encouraged capital mobilization in emerging ventures and persistence in shareholding, and related investing was significantly associated with lower risk of corporate bank failures. The results support a more positive view of family networks in business organizations and in overall economic development.
Resolving an open problem on the hazard rate ordering of p-spacings
Authors: Alimohammadi Mahdi
Published: November 2022

Let $V_{(r,n,\tilde {m}_n,k)}^{(p)}$ and $W_{(r,n,\tilde {m}_n,k)}^{(p)}$ be the $p$-spacings of generalized order statistics based on absolutely continuous distribution functions $F$ and $G$, respectively. Imposing some conditions on $F$ and $G$ and assuming that $m_1=\cdots =m_{n-1}$, Hu and Zhuang (2006. Stochastic orderings between p-spacings of generalized order statistics from two samples. Probability in the Engineering and Informational Sciences 20: 475) established $V_{(r,n,\tilde {m}_n,k)}^{(p)} \leq _{{\rm hr}} W_{(r,n,\tilde {m}_n,k)}^{(p)}$ for $p=1$ and left the case $p\geq 2$ as an open problem. In this article, we not only resolve it but also give the result for unequal $m_i$'s. It is worth mentioning that this problem has not been proved even for ordinary order statistics so far.
Documenting Indigenous oral traditions: Copyright for control
Authors: Oruç Pınar
Published: November 2022

Similar to the other forms of cultural heritage, Indigenous oral traditions are collected and held often by outsiders to the community. There are a number of instruments addressing this problem, but none of them provide complete control over such works. This article will focus on the possibility and instances of copyright being used to control oral traditions, both by outsiders and the Indigenous communities. The article will first provide an overview of the applicable legal areas (cultural property law, Indigenous rights, and intellectual property rights), and then it will assess different stages in the treatment of oral traditions. It will discuss the copyright implications for not only the traditions themselves but also their documented versions, subsequent copies, adaptations, and new works in order to provide a full picture of the relationship between control and copyright.
Sovereign dreams and bureaucratic strategies in princely Jaipur, c. 1750–1950
Authors: Dhabhai Garima
Published: November 2022

This article focuses on Jaipur city, capital of the Kachhawa Rajput state of Jaipur in the Rajputana region of north-western India (present-day Rajasthan). It seeks to braid the narrative of modernity in Jaipur with the tripartite networks of capital, knowledge and infrastructure that were contemporaneous to different phases of the city's transformation. Through a genealogical analysis of Jaipur's modernity from the eighteenth century to the mid-twentieth century, the article will present three distinct periods of its urbanization.
Regional Response of Land Hydrology and Carbon Uptake to Different Amounts of Solar Radiation Modification
Authors: Zhao Mengying , Cao Long
Published: November 2022

Solar radiation modification (SRM) is a proposed method to cool the Earth by intentionally perturbing the Earth's energy balance. One concern about the effect of SRM is disparities in the regional climate response. In this study, we use the Community Earth System Model (CESM1.2) to analyze the regional response of land hydrology and terrestrial carbon uptake to different amounts of SRM. The SRM is implemented by a uniform increase in volcanic‐size sulfate aerosols in the stratosphere under a doubling of atmospheric CO2. Our results show that different amounts of SRM could either moderate or exacerbate CO2‐induced changes in land hydrology including precipitation, precipitation minus evapotranspiration, and soil moisture (SM), but the effect varies widely across regions and specific variables. An “optimal” amount of SRM that moderates land hydrology changes for one region might exacerbate changes for other regions (or vice versa). Also, our study shows that for quite a few regions, partial SRM moderates CO2‐induced change in precipitation minus evaporation but exacerbates changes in CO2‐induced SM. The response of terrestrial Net primary productivity (NPP) to different amounts of SRM shows large regional disparities, depending on whether temperature or water availability constrains NPP more. Our study also shows that the effect of CO2 physiological forcing plays a key role in regulating land hydrology response to SRM, especially at the regional scale.
Anthropogenic Carbon Transport Variability in the Atlantic Ocean Over Three Decades
Authors: Caínzos Verónica , Velo Antón , Pérez Fiz F. , Hernández‐Guerra Alonso
Published: November 2022

The change in anthropogenic CO2 (Canth) in the Atlantic Ocean is linked to the Atlantic Meridional Overturning Circulation (AMOC), that redistributes Canth meridionally and in depth. We have employed direct biogeochemical measurements and hydrographic data from the last 30 years, adjusted using inverse models for each decade with both physical and biogeochemical constraints. We then have computed the meridional transports and the vertical transports between two sections at the interphases by advection and diffusion. We have focused on the repeated sections at three latitudes—30°S, 24, and 55°N, dividing the Atlantic into two boxes. We have divided the net transport into upper, deep and abyssal layers, with an upper and abyssal northward transport of Canth and a southward component in deep layers. The change in time in the net transports of Canth appears to be mainly due to modifications in the transport of upper layers. The lower layer of the AMOC, a combination of deep and abyssal waters, maintain more consistent transports in time. Vertical advection plays an important role in the North Atlantic, exporting Canth from upper to deep layers. In the South Atlantic, the newly formed Antarctic Bottom Water exports Canth from abyssal to deep layers. The strong gradient in Canth concentration at the interphase of upper and deep layers results in a strong vertical diffusion.
Water and Chlorine in the Martian Subsurface Along the Traverse of NASA's Curiosity Rover: 1. DAN Measurement Profiles Along the Traverse
Authors: Mitrofanov I. G. , Nikiforov S. Y. , Djachkova M. V. , Lisov D. I. , Litvak M. L. , Sanin A. B. , Vasavada A. R.
Published: November 2022

This paper presents estimates of the water and chlorine contents in the subsurface of Gale crater based on the measurements by the Dynamic Albedo of Neutrons (DAN) instrument onboard the NASA Curiosity rover. It is Part 1 of a two‐paper series. Data derived both from DAN active and passive measurements are presented in discrete surface areas (pixels) assuming a homogeneous distribution of water within the DAN sensing depth (60 cm) along the traverse of the rover. It is shown that the content of hydrogen, reported as Water Equivalent Hydrogen, varies between almost zero and a maximum of (6.1 ± 0.7) wt.%. The content of absorption equivalent chlorine varies between almost zero and (2.6 ± 0.2) wt.%. Such variations are thought to be related to the different geological processes and environmental conditions present in the strata along the traverse during the evolutionary history of Gale crater. The second paper (Part 2) studies particular properties of water and abundances of neutron absorbing elements at distinct geological regions, that the rover crossed on its way.
Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer
Authors: Zhao Qiuyan , Zhu Zhonglin , Xiao Wenqin , Zong Guanzhao , Wang Chuanyang , Jiang Weiliang , Li Kai , Shen Jie , Guo Xingya , Cui Jianhua , Guo Lihong , Wan Rong
Published: November 2022

Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is a hallmark of multiple cancers and is involved in tumor biology. However, little is known about the roles of circRNAs in glycolysis and hypoxia-mediated progression of PC. Here, the expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in PC tissues and may be a potential prognostic indicator. HIF-1α and EIF4A3 are involved in regulating the biogenesis of circRNF13. Furthermore, circRNF13 was validated to exert a stimulative effect on cell proliferation, angiogenesis, invasion and glycolysis. Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR-654-3p sponge, thus promoting the PC malignant process. Collectively, our results reveal that hypoxia-induced circRNF13 mediated by HIF-1α and EIF4A3 promotes tumor progression and glycolysis in PC, indicating the potential of circRNF13 as a prognostic biomarker and therapeutic target for PC.
Thermal property evaluation of a 2.5D integration method with device level microchannel direct cooling for a high-power GaN HEMT device
Authors: Lian Tingting , Xia Yanming , Wang Zhizheng , Yang Xiaofeng , Fu Zhiwei , Kong Xin , Lin Shuxun , Ma Shenglin
Published: November 2022

Gallium nitride high electron mobility transistor (GaN HEMT) devices have become critical components in the manufacturing of high-performance radio frequency (RF) or power electronic modules due to their superior characteristics, such as high electron saturation speeds and high power densities. However, the high heat characteristics of GaN HEMTs make device level cooling a critical problem to solve since performance degradation or even failure may occur under high temperatures. In this paper, we proposed a 2.5D integration method with device-level microchannel direct cooling for a high-power GaN HEMT device. To demonstrate this technological concept, a multigate GaN HEMT device featuring a gate length/width/source drain spacing of 0.5 μm/300 μm/6 μm that underwent in-house backside thinning and metallization was used as the test vehicle. A high-resistivity silicon (HR Si) interposer embedded with four-layer microchannels was designed, having widths/pitches of 30 μm/30 μm at the top microchannel. The high-power GaN HEMT device was soldered on a Si interposer embedded with open microchannels for heat dissipation. A pair of GSG Pad chips was soldered simultaneously to display the capacity for the heterogeneous integration of other chip types. Thermal property evaluation was conducted with experiments and simulations. The test results showed that the maximum surface temperature of the GaN HEMT device decreased to 93.8 °C when it experienced a heat dissipation density of 32 kW/cm2in the gate finger area and an average heat dissipation density of 5 kW/cm2was found in the active area with the DI water coolant at a flow rate of 3 mL/min. To our knowledge, among recently reported works, this finding was the best cooling capacity of heterogeneously integrated microchannels for GaN HEMT devices. In addition, this technology was scalable regarding the numbers of gate fingers or GaN HEMT devices.
The role of primary dental care practitioners in the long-term management of patients treated for head and neck cancer
Authors: Kalsi Harpoonam , McCaul Lorna K. , Rodriguez Jose M.
Published: November 2022

Patients treated for head and neck cancer may be susceptible to a higher incidence of dental disease due to long-term sequelae of treatment for head and neck cancer. Most patients with head and neck cancer are discharged from a hospital environment and responsibility for long-term dental care is transferred back from the restorative dentistry team to the dentist and dental care professionals in primary care. Treatment of these patients should be undertaken in a supportive environment, taking into account the physical and psychological repercussions of previous treatment. With the exception of some surgical procedures, routine dental care is not contraindicated in patients after head and neck cancer treatment and it is expected that the dentist and dental care professionals will be responsible for long-term routine dental treatment. Primary dental care practitioners should be aware of the process to refer patients back to the head and neck cancer multidisciplinary team if they note a suspicious change during their routine clinical examinations. Referral to a restorative dentistry consultant for planning and carrying out complex items of care may sometimes be necessary, but patients should always remain under the long-term care of their primary dental care practitioner.
Experimental realization of an extended Fermi-Hubbard model using a 2D lattice of dopant-based quantum dots
Authors: Wang Xiqiao , Khatami Ehsan , Fei Fan , Wyrick Jonathan , Namboodiri Pradeep , Kashid Ranjit , Rigosi Albert F. , Bryant Garnett , Silver Richard
Published: November 2022

The Hubbard model is an essential tool for understanding many-body physics in condensed matter systems. Artificial lattices of dopants in silicon are a promising method for the analog quantum simulation of extended Fermi-Hubbard Hamiltonians in the strong interaction regime. However, complex atom-based device fabrication requirements have meant emulating a tunable two-dimensional Fermi-Hubbard Hamiltonian in silicon has not been achieved. Here, we fabricate 3 × 3 arrays of single/few-dopant quantum dots with finite disorder and demonstrate tuning of the electron ensemble using gates and probe the many-body states using quantum transport measurements. By controlling the lattice constants, we tune the hopping amplitude and long-range interactions and observe the finite-size analogue of a transition from metallic to Mott insulating behavior. We simulate thermally activated hopping and Hubbard band formation using increased temperatures. As atomically precise fabrication continues to improve, these results enable a new class of engineered artificial lattices to simulate interactive fermionic models.
Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma
Authors: Zhang Dongya , Tian Sidan , Liu Yanjie , Zheng Meng , Yang Xiangliang , Zou Yan , Shi Bingyang , Luo Liang
Published: November 2022

Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation to achieve BBB crossing and deep tumor penetration of drugs. Synthesized by crosslinking pullulan and poly(deca-4,6-diynedioic acid) (PDDA) and loaded with temozolomide and indocyanine green (ICG), the nanogels are inert to endogenous oxidative conditions but can be selectively disintegrated by ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging the nanogels with apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation and active tumor targeting. The precisely controlled NIR irradiation on tumor lesions excites ICG and deforms the cumulated nanogels to trigger burst drug release for facilitated BBB permeation and infiltration into distal tumor cells. These NIR-activatable biomimetic nanogels suppress the tumor growth in orthotopic GBM and GBM stem cells-bearing mouse models with significantly extended survival.
Adsorption energies on transition metal surfaces: towards an accurate and balanced description
Authors: Araujo Rafael B. , Rodrigues Gabriel L. S. , dos Santos Egon Campos , Pettersson Lars G. M.
Published: November 2022

Density functional theory predictions of binding energies and reaction barriers provide invaluable data for analyzing chemical transformations in heterogeneous catalysis. For high accuracy, effects of band structure and coverage, as well as the local bond strength in both covalent and non-covalent interactions, must be reliably described and much focus has been put on improving functionals to this end. Here, we show that a correction from higher-level calculations on small metal clusters can be applied to improve periodic band structure adsorption energies and barriers. We benchmark against 38 reliable experimental covalent and non-covalent adsorption energies and five activation barriers with mean absolute errors of 2.2 kcal mol−1, 2.7 kcal mol−1, and 1.1 kcal mol−1, respectively, which are lower than for functionals widely used and tested for surface science evaluations, such as BEEF-vdW and RPBE.
Molecular identity of proprioceptor subtypes innervating different muscle groups in mice
Authors: Dietrich Stephan , Company Carlos , Song Kun , Lowenstein Elijah David , Riedel Levin , Birchmeier Carmen , Gargiulo Gaetano , Zampieri Niccolò
Published: November 2022

The precise execution of coordinated movements depends on proprioception, the sense of body position in space. However, the molecular underpinnings of proprioceptive neuron subtype identities are not fully understood. Here we used a single-cell transcriptomic approach to define mouse proprioceptor subtypes according to the identity of the muscle they innervate. We identified and validated molecular signatures associated with proprioceptors innervating back (Tox, Epha3), abdominal (C1ql2), and hindlimb (Gabrg1, Efna5) muscles. We also found that proprioceptor muscle identity precedes acquisition of receptor character and comprise programs controlling wiring specificity. These findings indicate that muscle-type identity is a fundamental aspect of proprioceptor subtype differentiation that is acquired during early development and includes molecular programs involved in the control of muscle target specificity.
Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling
Authors: Li Lun , Ren Jiangtao , Zhou Jingjie , Wu Xiaomei , Shao Zhihui , Yang Xiaodong , Qian Deyun
Published: November 2022

Enantioenriched N-alkylindole compounds, in which nitrogen is bound to a stereogenic sp3 carbon, are an important entity of target molecules in the fields of biological, medicinal, and organic chemistry. Despite considerable efforts aimed at inventing methods for stereoselective indole functionalization, straightforward access to a diverse range of chiral N-alkylindoles in an intermolecular catalytic fashion from readily available indole substrates remains an ongoing challenge. In sharp contrast to existing C–N bond-forming strategies, here, we describe a modular nickel-catalyzed C–C coupling protocol that couples a broad array of N-indolyl-substituted alkenes with aryl/alkenyl/alkynyl bromides to produce chiral N-alkylindole adducts in single regioisomeric form, in up to 91% yield and 97% ee. The process is amenable to proceed under mild conditions and exhibit broad scope and high functional group compatibility. Utility is highlighted through late-stage functionalization of natural products and drug molecules, preparation of chiral building blocks.
Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter
Authors: Sun Jianfeng , Li Xue , Hou Xuben , Cao Sujian , Cao Wenjin , Zhang Ye , Song Jinyang , Wang Manfu , Wang Hao , Yan Xiaodong , Li Zengpeng , Roeder Robert G. , Wang Wei
Published: November 2022

In eukaryotes, small nuclear RNAs (snRNAs) function in many fundamental cellular events such as precursor messenger RNA splicing, gene expression regulation, and ribosomal RNA processing. The snRNA activating protein complex (SNAPc) exclusively recognizes the proximal sequence element (PSE) at snRNA promoters and recruits RNA polymerase II or III to initiate transcription. In view that homozygous gene-knockout of SNAPc core subunits causes mouse embryonic lethality, functions of SNAPc are almost housekeeping. But so far, the structural insight into how SNAPc assembles and regulates snRNA transcription initiation remains unclear. Here we present the cryo-electron microscopy structure of the essential part of human SNAPc in complex with human U6-1 PSE at an overall resolution of 3.49 Å. This structure reveals the three-dimensional features of three conserved subunits (N-terminal domain of SNAP190, SNAP50, and SNAP43) and explains how they are assembled into a stable mini-SNAPc in PSE-binding state with a “wrap-around” mode. We identify three important motifs of SNAP50 that are involved in both major groove and minor groove recognition of PSE, in coordination with the Myb domain of SNAP190. Our findings further elaborate human PSE sequence conservation and compatibility for SNAPc recognition, providing a clear framework of snRNA transcription initiation, especially the U6 system.
PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow
Authors: Yu Yao , Wang Rong-Rong , Miao Nai-Jun , Tang Jia-Jie , Zhang Yun-Wei , Lu Xiang-Ran , Yan Pei-Yi , Wang Jing , Jia Xin-Ming
Published: November 2022

Programmed death ligand 1 (PD-L1) has been shown to be inducibly expressed on neutrophils to suppress host immunity during polymicrobial sepsis, virus and parasite infections. However, the role of PD-L1 on neutrophil-mediated antifungal immunity remains wholly unknown. Here, we show that the expression of PD-L1 on murine and human neutrophils was upregulated upon the engagement of C-type lectin receptor Dectin-1 with its ligand β-glucans, exposed on fungal pathogen Candida albicans yeast. Moreover, β-glucan stimulation induced PD-L1 translocation into nucleus to regulate the production of chemokines CXCL1 and CXCL2, which control neutrophil mobilization. Importantly, C. albicans infection-induced expression of PD-L1 leads to neutrophil accumulation in bone marrow, through mediating their autocrine secretion of CXCL1/2. Furthermore, neutrophil-specific deficiency of PD-L1 impaired CXCL1/2 secretion, which promoted neutrophil migration from bone marrow into the peripheral circulation, thereby conferring host resistance to C. albicans infection. Finally, either PD-L1 blockade or pharmacological inhibition of PD-L1 expression significantly increased neutrophil release from bone marrow to enhance host antifungal immunity. Our data together indicate that activation of Dectin-1/PD-L1 cascade by β-glucans inhibits neutrophil release from bone marrow reserve, contributing to the negative regulation of antifungal innate immunity, which functions as a potent immunotherapeutic target against life-threatening fungi infections.
The Health Gym: synthetic health-related datasets for the development of reinforcement learning algorithms
Authors: Kuo Nicholas I-Hsien , Polizzotto Mark N. , Finfer Simon , Garcia Federico , Sönnerborg Anders , Zazzi Maurizio , Böhm Michael , Kaiser Rolf , Jorm Louisa , Barbieri Sebastiano
Published: November 2022

In recent years, the machine learning research community has benefited tremendously from the availability of openly accessible benchmark datasets. Clinical data are usually not openly available due to their confidential nature. This has hampered the development of reproducible and generalisable machine learning applications in health care. Here we introduce the Health Gym - a growing collection of highly realistic synthetic medical datasets that can be freely accessed to prototype, evaluate, and compare machine learning algorithms, with a specific focus on reinforcement learning. The three synthetic datasets described in this paper present patient cohorts with acute hypotension and sepsis in the intensive care unit, and people with human immunodeficiency virus (HIV) receiving antiretroviral therapy. The datasets were created using a novel generative adversarial network (GAN). The distributions of variables, and correlations between variables and trends in variables over time in the synthetic datasets mirror those in the real datasets. Furthermore, the risk of sensitive information disclosure associated with the public distribution of the synthetic datasets is estimated to be very low.
WES data from 286 diffuse gliomas under the 2021 WHO Classification of Tumors of the Central Nervous System
Authors: Zhao Zheng , Zhang Ke-Nan , Sun Zhiyan , Yang Changlin , Wang Qiangwei , Li Guanzhang , Wang Zhiliang , Zeng Fan , Chai Ruichao , Qian Zenghui , Wang Zheng , Liu Yanwei , Ma Wenping , Wu Fan , Jiang Tao
Published: November 2022

Diffuse gliomas (DGs) are the most common and lethal primary neoplasms in the central nervous system. The latest 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) was published in 2021, immensely changing the approach to diagnosis and decision making. As a part of the Chinese Glioma Genome Atlas (CGGA) project, our aim was to provide genomic profiling of gliomas in a Chinese cohort. Two hundred eighty six gliomas with different grades were collected over the last decade. Using the Illumina HiSeq platform, over 75.8 million high-quality 150 bp paired-end reads were generated per sample, yielding a total of 43.4 billion reads. We also collected each patient’s clinical and pathological information and used it to annotate their genetic data. All patients were diagnosed and classified by neuro-pathologist under the 2021 WHO classification. This dataset provides an important reference for researchers and will significantly advance our understanding of gliomas.
Catalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors
Authors: Koh Eunhee , Kim Uijin , Cho Hyun-Soo
Published: November 2022

Pathogenic bacteria encode virulent glycosyltransferases that conjugate various glycans onto host crucial proteins, which allows adhesion to mammalian cells and modulates host cellular processes for pathogenesis. Escherichia coli NleB1, Citrobacter rodentium NleB, and Salmonella enterica SseK1/3 type III effectors fatally glycosyltransfer N-acetyl glucosamine (GlcNAc) from UDP-GlcNAc to arginine residues of death domain-containing proteins that regulate host inflammation, intra-bacterial proteins, and themselves, whose post-translational modification disrupts host immune functions and prolongs bacterial viability inside host cells. However, unlike the similar NleB1/SseK1/SseK3, E. coli NleB2 and S. enterica SseK2 show deficient GlcNAcylation and neither intra-bacterial glycosylation nor auto-glycosylation. Here, as the major factor in SseK2/NleB2 deficiency, we focused on the catalytic Asp-x-Asp (DxD) motif conserved throughout all O-/N-glycosyltransferases to coordinate Mn2+. All DxD motifs in apo-glycosyltransferases form Type-I-turns for binding Mn2+, similar to the ligand-bound DxD motif, whereas TcnA/SseK2/NleB2 DxD motifs form Asx-turns, which are unable to bind Mn2+. Interestingly, methionine of the NleB2 DMD motif forms triple Met–aromatic interactions, as found in age-associated diseases and tumor necrosis factor (TNF) ligand-receptor complexes. The NleB1 A222M mutation induces triple Met–aromatic interactions to steeply attenuate glycosylation activity to 3% of that in the wild type. Thus, the characteristic conformation of the DxD motif is essential for binding Mn2+, donors, and glycosylate targets. This explains why SseK2/NleB2 effectors with the DxD motif caged in the Asp-/Asn-turn (Asx-turn) and triple Met–aromatic interactions have lower glycosyltransferase activity than that of other fatal NleB1/SseK1/SseK3 toxins.
Capturing SARS-CoV-2 from patient samples with low viral abundance: a comparative analysis
Authors: Pipoli da Fonseca Juliana , Kornobis Etienne , Turc Elodie , Enouf Vincent , Lemée Laure , Cokelaer Thomas , Monot Marc
Published: November 2022

Since the beginning of the SARS-CoV-2 coronavirus pandemic, genome sequencing is essential to monitor viral mutations over time and by territory. This need for complete genetic information is further reinforced by the rapid spread of variants of concern. In this paper, we assess the ability of the hybridization technique, Capture-Seq, to detect the SARS-CoV-2 genome, either partially or in its integrity on patients samples. We studied 20 patient nasal swab samples broken down into five series of four samples of equivalent viral load from CT25 to CT36+ . For this, we tested 3 multi-virus panel as well as 2 SARS-CoV-2 only panels. The panels were chosen based on their specificity, global or specific, as well as their technological difference in the composition of the probes: ssRNA, ssDNA and dsDNA. The multi-virus panels are able to capture high-abundance targets but fail to capture the lowest-abundance targets, with a high percentage of off-target reads corresponding to the abundance of the host sequences. Both SARS-CoV-2-only panels were very effective, with high percentage of reads corresponding to the target. Overall, capture followed by sequencing is very effective for the study of SARS-CoV-2 in low-abundance patient samples and is suitable for samples with CT values up to 35.