bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS MICROSOFT SWAY PADA MATERI HUKUM GERAK NEWTON DI SMA
Authors: Petriati Septi , Purwanto Andik , Medriati Rosane
Published: July 2024

ABSTRAK
 
Penelitian ini bertujuan untuk mendeskripsikan dan menggembangkan media pembelajaran berbasis Microsoft Sway pada materi Hukum Gerak Newton di SMA. Penelitian dilakukan di SMAN 6 Kota Bengkulu. Penelitian ini merupakan penelitian dan pengembangan (R & D) dengan metode 4D yang telah dimodifikasi menjadi 3D dan terdiri dari tahap pendefinisian atau define, perancangan atau design, dan pengembangan atau develope. Tahap define terdiri dari hasil studi literatur dan analisis kebutuhan. Tahap design pada penelitian ini yaitu pemilihan media dan materi perancangan, serta perancangan awal media pembelajaran. Tahap develop dalam penelitian ini merupakan validasi ahli yang terdiri dari 3 orang ahli. Hasil dari validasi ahli dengan aspek kelayakan isi sebesar 85,83%, aspek bahasa sebesar 89,58%, aspek penyajian sebesar 85,41%, dan aspek kegrafisan sebesar 83,33%. Total validasi yang dilakukan oleh validator rata-rata sebesar 86,03%. Dengan demikian media pembelajaran berbasis Microsoft Sway pada materi Hukum Gerak Newton memenuhi kriteria sangat layak diujicobakan di SMA pada siswa kelas X.
 
Kata kunci : Media Pembelajaran, Online, Microsoft Sway, Hukum Gerak Newton
 
ABSTRACT
 
This study aims to describe and develop learning media based on Microsoft Sway on Newton's Laws of Motion in high school. The research was conducted at SMAN 6 Bengkulu City. This research is a research and development (R & D) with the 4D method which has been modified into 3D and consists of the stages of defining or define, design or design, and development or develope. The define stage consists of the results of the literature study and needs analysis. The design stage in this research is the selection of media and design materials, as well as the initial design of learning media. The develop stage in this research is an expert validation consisting of 3 experts. The results of expert validation with content feasibility aspects are 85.83%, language aspects are 89.58%, presentation aspects are 85.41%, and graphic aspects are 83.33%. The total validation carried out by validators is 86.03% on average. Thus, the Microsoft Sway-based learning media on Newton's Laws of Motion material meets the criteria very worthy of being tested in high school for class X students.
 
Keyword : Learning Media, Online, Microsoft Sway, Newton's Laws of Motion
PERTUMBUHAN DAN HASIL KACANG HIJAU DALAM PERSAINGAN DENGAN TEKI DAN RUMPUT BELULANG DI TANAH STERIL DAN NON STERIL
Authors: Harmaeni Harmaeni , Wangiyana Wayan
Published: July 2024

This study aimed to determine the effect of competition with nutsedge and Eleucine grasses in autoclave sterilized and non-sterililized soil on growth and yield of mungbean. The experiment was carried out in the glasshouse of the Faculty of Agriculture, University of Mataram, from January to March 2015, arranged in a Completely Randomized Design (CRD), testing 3 treatment factors namely; two soil conditions (autoclave sterilized and non-sterilized), two types of weeds (nutsedge and Eleucine), and weed populations (0, 2 and 4 clumps / polybag), each of which was replicated 3 times, so there were 36 experimental units for each series. The experiment was made in 2 series; first series for measurement of plant dry weight at 6 weeks after seeding, and the second series was for measurement of mungbean seed yield. The results indicated that the three treatment factors affected growth and yield of mungbean. Growth of the mungbean plants was better in the non-sterilized soil compared with in sterilized soil. In terms of weed competition, Eleucine grass was more severe in suppressing growth and yield of mungbean compared with nutsedge grass, whereas of weed population, the treatment without (0) weeds resulted in much better growth of mungbean plants than the treatments of 2 or 4 weeds per polybag
APPLICATION OF ORGANIC FERTILIZER AND AEROBIC IRRIGATION SYSTEM ON SEVERAL VARIETIES OF LOWLAND RICE TO INCREASE YIELD OF SOYBEAN DIRECT-SEEDED FOLLOWING RICE
Authors: Maemunah Maemunah , Wangiyana Wayan
Published: July 2024

This study aimed to examine the effect of cultivation techniques of several varieties of lowland rice between conventional techniques and aerobic irrigation systems, and the application of organic fertilization using bokashi (EM-4 fermented) cattle manure, on yield of Anjasmoro variety of soybean direct-dibbled following harvest of rice without tillage, by conducting pot experiment in a plastic house from September to December 2015. The experiment was designed according to factorial Completely Randomized Design consisting of 3 treatment factors, namely rice cultivation techniques (T1: conventional, T2: aerobic irrigation systems), lowland rice varieties (V1: Inpari 23, V2: Inpari 24, V3: Inpari 25), and organic fertilizer (P0: non-organic, P1: with organic fertilizer), and each treatment combination was made in three replications. The seeding of soybean of Anjasmoro variety was done by immediately dibbling the seeds after harvesting rice in accordance with the treatment factors without tillage. The results indicated that rice cultivation techniques and application of organic fertilizer had significant effects on growth and yield components of soybean, and there was an interaction effect but only between cultivation techniques and rice varieties on the trifoliate leaf number at the age of 49 days, but the rice varieties did not affect growth and yield of soybean following rice crops. The seed yield was higher on soybean following rice of aerobic irrigation system (20.65 g/pot) than following conventional rice (17.92 g/pot), and it was higher on pots receiving organic fertilizer (23.29 g/pot) compared to without organic fertilizer (15.28 g/pot). Even without organic fertilizer, seed yield was higher (16.59 g/pot) in soybeans direct-seeded following aerobic rice compared to following conventional rice (13.98 g/pot).
STRUKTUR DAN KOMPOSISI VEGETASI DI KAWASAN HUTAN RAKYAT DUSUN MURPAYUNG DESA SIGAR PENJALIN KABUPATEN LOMBOK UTARA
Authors: Maje Yohanes Osmundus , Ratnaningsih Yulia
Published: July 2024

Penelitian ini bertujuan untuk Mengetahui potensi  Ekowisata Air Terju Ogi Di Kelurahan Faobata Kabupaten Ngada Propinsi Nusa Tenggara Timur . Metode dan analisis data yang digunakan adalah metode deskriptif yaitu metode yang mengumpulkan, menyusun, dan menganalisis serta menginterprestasikan dan kemudian menarik kesimpulan. Sumber data yang di peroleh melalui: wawancara, observasi, kepustakaan, dan dokumentasi dan data yang di peroleh akan di analisis menggunakan analisis SWOT. Hasil penelitian menunjukan bahwa potensi ekowisata yang terdapat di Kawasan Ekowisata Air terjun Ogi adalah Potensi Panorama Alam, memiliki ketinggian 30m, aliran air yang bersih pada sungai, kondisi lingkungan yang masih alami dan stabil dan Potensi Flora dan Fauna. Berdasarkan hasil penelitian  ekowisata Air terjun Ogi memiliki beberapa kriteria adalah Atraksi alam (potensi alam, lokasi, budaya, dan hiburan) Aksesibilitas (jarak, waktu tempuh, biaya perjalanan, intensitas lokasi), Sarana dan Prasarana (transportasi, tempat parkir, listrik, akses komunikasi, sistem keamanan dan penyelamatan, dan sarana pendukung), dampak lingkungan yang potensial, informasi wisata, organisasi dan kelembagaan, dan dukungan pelaku wisata. Ekowisata Air terjun Ogi juga memeiliki beberapa faktor antara lain: Kekuatan, Kelemahan, Peluang dan Ancaman. Pengembangan ekowisata air terjun Ogi sangat perlu dilakukan karena nantinya dapat menambah pendapatan daerah serta membuka lapangan pekerjaan untuk masyarakat sekitar kawasan Wisata  Air terjun Ogi.
ANALISIS KELAYAKAN USAHA TANI NILAM (Pogostemon cablin) SEBAGAI PENGHASIL HASIL HUTAN BUKAN KAYU (STUDI KASUS KELOMPOK TANI PUSUK PAS WILAYAH BKPH RINJANI BARAT)
Authors: Putra Akhmad Gufran Septiyani , Ratnaningsih Yulia
Published: July 2024

Nilam (Pogostemon cablin) merupakan jenis hasil hutan bukan kayu yang banyak di usahakan masyarakat karena mudah untuk di budidayakan serta memiliki harga yang tinggi. Tanaman nilam merupakan penghasil minyak atsiri sebagai bahan pewangi yang memiliki banyak peminat. Tujuan dari penelitian ini untuk mengetahui gambaran kegiatan usaha tani nilam, faktor pendukung dan penghambat dalam pengembangan nilam dan mengetahui kelayakan usaha tani nilam. Jumlah responden digunakan sebanyak 20 orang dengan menggunakan teknik sensus. Hasil penelitian menunjukan bahwa pendapatan usaha tani nilam dalam sekali panen rata-rata Rp. 198.375 dan kelayakan usaha tani nilam sebesar 1,58 dimana hal ini menunjukan setiap pengeluaran Rp. 1 maka mengdapatkank atau menghasilkan sebesar Rp. 1,58.
Distinct natal origins based on vertebral ring analysis corroborate the migration pattern of Pacific bluefin tuna in the North Pacific Ocean
Authors: Uematsu Y , Ishihara T , Shimose T , Chen KS , Mohan JA , Rooker JR , Wells RJD , Snodgrass OE , Dewar H , Ohshimo S , Tanaka Y
Published: July 2024

Pacific bluefin tuna (PBF) Thunnus orientalis have 2 major spawning grounds and migrate widely in the North Pacific Ocean. To understand the population structure and migratory ecology, we analyzed vertebral samples collected from a wide range of ages and areas and then estimated their natal ground from the first annulus in the vertebra, which does not change significantly after formation. Both spawning groups of PBF, including fish that originated from the Sea of Japan (assigned as group SJ) and from the waters around the Ryukyu Archipelago and Taiwan (group RT), were observed in all sampling areas and age classes. In younger age classes, the percentages of group SJ were higher around Japan, whereas those of group RT were higher in the eastern Pacific Ocean (EPO). The percentage of group RT decreases around Japan as they migrate to the EPO and then increases when they return. These results suggest a tendency toward different migration patterns depending on the natal area. Interestingly, the results suggest that fish from the EPO rarely migrate to the Sea of Japan. The percentages of group RT for age 10+ were similar and higher in all sampling areas, and these are considered to be the final percentages of the relative contribution of the 2 natal grounds. This is a useful approach that enables us to easily examine the relative contribution of the 2 spawning grounds across time and space, providing insights into the dynamics of movement around the Pacific based on variations in the population composition.
Methodical approach to determining goals artillery of the mechanism brigade
Authors: Mokrotsky Muhaylo , Shostak Roman
Published: July 2024

The experience of repelling and deterring the armed aggression of the Russian Federation shows the need to carry out a significant amount of fire support tasks for combined military units (units) and points to the growing requirements for the timeliness and quality of target identification for missile troops and artillery at various stages of preparation and conducting an operation (battle).
The conducted analysis of the use of artillery units during the repulse of the armed aggression of the Russian Federation indicates that the issues of increasing the level of implementation of their combat capabilities and bringing them into line with the volume of fire tasks that can rely on artillery in the battle of a mechanized brigade are problematic and relevant today.
At present, there is an urgent need for modern methods and approaches that would take into account the changes that have occurred in the tactics of artillery units, their quantitative and qualitative composition, spatial and temporal parameters of the conduct of hostilities, and allow more qualitative justification of the goals for the division of units in order to achieve planned fire support effects. Therefore, a methodical approach to determining the goals of the artillery of the mechanized brigade is an important component of determining the scope of target engagement tasks and firing tasks of artillery in the battle of the mechanized brigade.
It is known that the scope of the target engagement task and the number of phases of actions related to their implementation depends on: the composition, state and nature of the enemy's actions; tasks of fire support of mechanized units; designation of artillery units as elements of the battle order of the mechanized brigade; combat properties, state and supply of ammunition of artillery units; the capabilities of intelligence tools and the results of processing intelligence information about enemy objects; planned effects of hitting targets, etc.
Therefore, there is an urgent task regarding the development of a methodical approach to determining the goals of the artillery of the mechanized brigade, as the number of objects (personnel, structures, etc.) of the enemy's troops (forces), districts and areas of the terrain that are accepted for destruction in the lane of action of the mechanized brigade for to achieve certain physical, operational and psychological effects in accordance with the intentions (design) of the brigade commander.
Use of portable ground radio locator when performing territorial defense tasks
Authors: Postupalsky Serhiy , Kasatkin Evgeny , Music Oleksandr , Mykytyn Volodymyr
Published: July 2024

Currently, a lot of attention is paid to the creation of a medium-range radar station (Radar), which ensures the detection of a single person at a distance of 4-5 km and armored vehicles at a distance of up to 10-12 km. At the same time, in the process of creating modern medium-range radars, the main attention is paid to: automation of the target detection process, which gives them a fundamentally new quality in relation to the fleet of existing radars of this class; the possibility of installing these radars on vehicles together with portable options, ensuring automatic leveling by the system antenna; increasing the reliability, reducing the mass and energy consumption of the radar while ensuring high resolution and accuracy of target coordinate measurement.
Work in the millimeter range of wavelengths, which facilitates the solution of a number of technical tasks: does not create obstacles for radio technical means; increases immunity to accidental and deliberate obstacles; practically harmless to human health. According to the principle of operation, the reconnaissance station is a coherent-Doppler radar of continuous radiation in the millimeter range with a phase-co-manipulated signal. Radar.
An analysis of the factors that determine the complexity of the functioning of the engineering and technical control system and ways to increase the efficiency of the system by combining various technical means of protecting the state border of Ukraine was carried out. The principles of operation of the technical means of the systems used to protect important state facilities are analyzed. The possibilities of using radar for conducting radar reconnaissance during the organization of the protection of important state objects, their advantages and possibilities are substantiated.
The purpose of the work is to develop an algorithm for determining the rational composition of forces and means of radar reconnaissance and their ability to determine the coordinates of moving and stationary objects.
Comparative analysis of aerosol camouflage means in army in the Armed Forces of Ukraine and armies of western partner countries
Authors: Tansiura Igor , Klimov Oleksii , Stakhovsky Oleg , Huzenko Serhii
Published: July 2024

In the article analises means of use aerosols allows to create curtains that complicate or completely exclude the aimed use of high-precision weapons is showd. Analysis of recent armed conflicts shows that in conditions of aerosol masking, the effectiveness of using conventional ammunition decreased by 8-12 times. At the same time, the percentage of defeat of armored targets especially decreased. It is also advisable to use aerosol curtains for protection against drones and guided munitions with laser and thermal imaging guidance systems. Currently, military experts often emphasize the growing role and importance of camouflage of troops and objects to achieve success in conducting combat operations in modern conditions. This is determined, first of all, by the appearance of new means of reconnaissance and surveillance, as well as samples of high-precision guided weapons that work in different radiation spectra, which creates additional difficulties in terms of misleading the enemy and reducing their losses in combat equipment, personnel in the event its application. In the conditions of the continuation of the reform of the Armed Forces of Ukraine, the problems of reducing the visibility of the troops, their protection from the fire impact of any type of enemy weapons, and above all, from high-precision weapons, deserve special attention and urgency.
Means of aerosol masking, which are in service with the Armed Forces of Ukraine, are morally outdated and do not meet modern requirements for masking. Aerosol generators, which are in service with the armies of Western partner countries, provide broad-spectrum camouflage, but are expensive. Therefore, there is a need to find solutions for low-cost improvement of aerosol generators of the Armed Forces of Ukraine.
The Case for Maghrebography: Accounting for Linguistic Indigeneity in a Multilingual Literary Testimony
Authors: El Guabli Brahim
Published: July 2024

I argue that Maghrebography, which is a multilingual and transnational Tamazghan literary corpus as well as a proactively multilingual mode of reading, can account for the indigenous and indigenized languages of Tamazghan literary and cultural studies. Essentially, Maghrebography requires a proactive endeavour to learn and engage with all the languages of cultural production in Tamazgha. This article explains how the marginalization of Tamazgha's indigenous languages has led to an entrenched Arabic-French dichotomy that continues to dominate scholarly approaches to the study of and specialization in Tamazghan literature and culture regardless of the fact that Imazighen – the Indigenous people of Tamazgha – have transformed the landscape of cultural production in their ancestral homeland. In its broader implications, Maghrebography calls for a new kind of scholarship that will redefine the field currently known as Maghrebi Studies by spurring curricular and programmatic changes that account for the land's indigenous language and culture.
Digital Transformation in Management Accounting: Towards Efficiency and Competitive Advantage
Authors: Rosmala Cici
Published: July 2024

Exploring the impact of digital transformation on management accounting, this study aims to identify pathways towards enhanced efficiency and competitive advantage. Employing a qualitative research design, the investigation involved a purposive sampling of medium-sized enterprises, with data gathered through structured interviews and analyzed using thematic analysis. The findings reveal significant shifts in operational dynamics, notably in data management and strategic decision-making, with themes highlighting the integration of advanced technologies fostering streamlined processes. Discussion centers on the implications of these transformations for organizational agility and market positioning. The study concludes with recommendations for leveraging digital tools to reinforce management accounting practices, ultimately contributing to sustained organizational growth
Data redundancy of blockchain systems in construction projects
Authors: Lu Weisheng , Wu Liupengfei , Chen Chen
Published: July 2024

Industrial stakeholders have complained that current blockchain systems are too expensive, particularly in temporary endeavours like construction projects. However, while researchers have examined blockchain system structure among inter-firm organizations in construction, little research has considered the data redundancy of these systems. This research, therefore, provides insight by modelling data redundancy in construction project blockchain systems. We conduct a series of laboratory experiments on a Hyperledger Fabric blockchain system, discovering that the data volume of a blockchain system grows proportionally with the size of the files to be uploaded, the number of peer nodes in the network, and the frequency of blockchain operations in construction, regardless of the block size or how the peers are dispersed in different construction organizations. Beyond identifying the factors that determine data redundancy of a blockchain system, this research provides a basis for researchers to explore the optimization of blockchain storage and the impacts of blockchain system data redundancy in construction projects. In practical terms, the proposed data redundancy model in this research provides a reference for users in construction who aim to build blockchain systems.
Current progress in strategies to profile transcriptomic m6A modifications
Authors: Yang Yuening , Lu Yanming , Wang Yan , Wen Xianghui , Qi Changhai , Piao Weilan , Jin Hua
Published: July 2024

Various methods have been developed so far for detecting N6-methyladenosine (m6A). The total m6A level or the m6A status at individual positions on mRNA can be detected and quantified through some sequencing-independent biochemical methods, such as LC/MS, SCARLET, SELECT, and m6A-ELISA. However, the m6A-detection techniques relying on high-throughput sequencing have more effectively advanced the understanding about biological significance of m6A-containing mRNA and m6A pathway at a transcriptomic level over the past decade. Various SGS-based (Second Generation Sequencing-based) methods with different detection principles have been widely employed for this purpose. These principles include m6A-enrichment using antibodies, discrimination of m6A from unmodified A-base by nucleases, a fusion protein strategy relying on RNA-editing enzymes, and marking m6A with chemical/biochemical reactions. Recently, TGS-based (Third Generation Sequencing-based) methods have brought a new trend by direct m6A-detection. This review first gives a brief introduction of current knowledge about m6A biogenesis and function, and then comprehensively describes m6A-profiling strategies including their principles, procedures, and features. This will guide users to pick appropriate methods according to research goals, give insights for developing novel techniques in varying areas, and continue to expand our boundary of knowledge on m6A.
Expression profile and gap-junctional transfer of microRNAs in the bovine cumulus-oocyte complex
Authors: Six R. , Benedetti C. , Fan Y. , Guan X. , Gansemans Y. , Hedia Mohamed , Bogado Pascottini O. , Pavani K. C. , Van Nieuwerburgh F. , Deforce D. , Smits K. , Van Soom A. , Peelman L.
Published: July 2024

MicroRNAs (miRNA) are important regulators of oocyte maturation, playing a key role in modulating gene expression both in a temporal- and spatial-specific manner. These small non-coding RNAs are involved in important processes during oocyte maturation, acting as messengers between the oocyte and its surrounding cumulus cells. Despite its significance, the bidirectional communication mechanism is still unknown. To test miRNA communication between oocyte and surrounding cumulus cells through the gap junctions the gap junctions were either blocked with carbenoxolone or not. MiRNA sequencing of oocytes at 1, 6, and 22 h of in vitro maturation was then performed. Among the differentially expressed miRNAs, bta-miR-21-5p, a regulator of cumulus cell viability and oocyte maturation, was the only previously known miRNA. Furthermore, by labeling a bta-miR-21-5p mimic with FAM, crossing of this miRNA through the gap junctions within the cumulus-oocyte complex could be visualized and internalization in the oocyte was confirmed by RT-qPCR. In conclusion, this study provides, for the first time, evidence that miRNA communication within the bovine cumulus-oocyte complex is enabled through the gap junctional network.
Fast reconstruction of SMS bSSFP myocardial perfusion images using noise map estimation network (NoiseMapNet): a head-to-head comparison with parallel imaging and iterative reconstruction
Authors: Adam Naledi Lenah , Kowalik Grzegorz , Tyler Andrew , Mooiweer Ronald , Neofytou Alexander Paul , McElroy Sarah , Kunze Karl , Speier Peter , Stäb Daniel , Neji Radhouene , Nazir Muhummad Sohaib , Razavi Reza , Chiribiri Amedeo , Roujol Sébastien
Published: July 2024

Background

Simultaneous multi-slice (SMS) bSSFP imaging enables stress myocardial perfusion imaging with high spatial resolution and increased spatial coverage. Standard parallel imaging techniques (e.g., TGRAPPA) can be used for image reconstruction but result in high noise level. Alternatively, iterative reconstruction techniques based on temporal regularization (ITER) improve image quality but are associated with reduced temporal signal fidelity and long computation time limiting their online use. The aim is to develop an image reconstruction technique for SMS-bSSFP myocardial perfusion imaging combining parallel imaging and image-based denoising using a novel noise map estimation network (NoiseMapNet), which preserves both sharpness and temporal signal profiles and that has low computational cost.

Methods

The proposed reconstruction of SMS images consists of a standard temporal parallel imaging reconstruction (TGRAPPA) with motion correction (MOCO) followed by image denoising using NoiseMapNet. NoiseMapNet is a deep learning network based on a 2D Unet architecture and aims to predict a noise map from an input noisy image, which is then subtracted from the noisy image to generate the denoised image. This approach was evaluated in 17 patients who underwent stress perfusion imaging using a SMS-bSSFP sequence. Images were reconstructed with (a) TGRAPPA with MOCO (thereafter referred to as TGRAPPA), (b) iterative reconstruction with integrated motion compensation (ITER), and (c) proposed NoiseMapNet-based reconstruction. Normalized mean squared error (NMSE) with respect to TGRAPPA, myocardial sharpness, image quality, perceived SNR (pSNR), and number of diagnostic segments were evaluated.

Results

NMSE of NoiseMapNet was lower than using ITER for both myocardium (0.045 ± 0.021 vs. 0.172 ± 0.041, p < 0.001) and left ventricular blood pool (0.025 ± 0.014 vs. 0.069 ± 0.020, p < 0.001). There were no significant differences between all methods for myocardial sharpness (p = 0.77) and number of diagnostic segments (p = 0.36). ITER led to higher image quality than NoiseMapNet/TGRAPPA (2.7 ± 0.4 vs. 1.8 ± 0.4/1.3 ± 0.6, p < 0.001) and higher pSNR than NoiseMapNet/TGRAPPA (3.0 ± 0.0 vs. 2.0 ± 0.0/1.3 ± 0.6, p < 0.001). Importantly, NoiseMapNet yielded higher pSNR (p < 0.001) and image quality (p < 0.008) than TGRAPPA. Computation time of NoiseMapNet was only 20s for one entire dataset.

Conclusion

NoiseMapNet-based reconstruction enables fast SMS image reconstruction for stress myocardial perfusion imaging while preserving sharpness and temporal signal profiles.
Understanding testicular single cell transcriptional atlas: from developmental complications to male infertility
Authors: Tirumalasetty Munichandra Babu , Bhattacharya Indrashis , Mohiuddin Mohammad Sarif , Baki Vijaya Bhaskar , Choubey Mayank
Published: July 2024

Spermatogenesis is a multi-step biological process where mitotically active diploid (2n) spermatogonia differentiate into haploid (n) spermatozoa via regulated meiotic programming. The alarming rise in male infertility has become a global concern during the past decade thereby demanding an extensive profiling of testicular gene expression. Advancements in Next-Generation Sequencing (NGS) technologies have revolutionized our empathy towards complex biological events including spermatogenesis. However, despite multiple attempts made in the past to reveal the testicular transcriptional signature(s) either with bulk tissues or at the single-cell, level, comprehensive reviews on testicular transcriptomics and associated disorders are limited. Notably, technologies explicating the genome-wide gene expression patterns during various stages of spermatogenic progression provide the dynamic molecular landscape of testicular transcription. Our review discusses the advantages of single-cell RNA-sequencing (Sc-RNA-seq) over bulk RNA-seq concerning testicular tissues. Additionally, we highlight the cellular heterogeneity, spatial transcriptomics, dynamic gene expression and cell-to-cell interactions with distinct cell populations within the testes including germ cells (Gc), Sertoli cells (Sc), Peritubular cells (PTc), Leydig cells (Lc), etc. Furthermore, we provide a summary of key finding of single-cell transcriptomic studies that have shed light on developmental mechanisms implicated in testicular disorders and male infertility. These insights emphasize the pivotal roles of Sc-RNA-seq in advancing our knowledge regarding testicular transcriptional landscape and may serve as a potential resource to formulate future clinical interventions for male reproductive health.
Asymmetric Nash bargaining for cooperative operation of shared energy storage with multi-type users engagement
Authors: Xu Mengyao , Yang Yongbiao , Xu Qingshan , Fang Lele , Tang Rongchuan , Ji Hemu
Published: July 2024

Shared energy storage offers substantial savings on construction costs and improves energy efficiency for users, yet its business model as an independent economic entity remains unclear. An optimal scheduling method for cooperative operation of shared energy storage among multiple user types is proposed in this paper, which relied on asymmetric Nash bargaining to define operational schedules and pricing strategies effectively. Initially, a cost-benefit model for shared energy storage operators, along with power generation users, demand-side consumers, and microgrid prosumers is developed. Then, a cooperative game framework is established using asymmetric Nash bargaining principles which decomposes the problem into two parts: minimizing social total cost through cooperative operation scheduling and determining service fee pricing for equitable benefit distribution. For benefit distribution, the bargaining power of users is adjusted based on their alliance contribution, ensuring revenue distribution is aligned with individual contributions and improving fairness in pricing. Subsequently, the adaptive penalty factor alternating direction multiplier method (ADMM) algorithm is employed for distributed equilibrium solving, enhancing the convergence speed and safeguarding user privacy. Finally, the economics and feasibility of the proposed cooperation framework for shared energy storage are validated through a numerical example.
Assessment of land use dynamics and vulnerability to land degradation in coal-mined landscapes of central India: implications for ecorestoration strategies
Authors: Thakur Tarun Kumar , Swamy S. L. , Dutta Joystu , Thakur Anita , Mishra Alka , Sarangi Prakash Kumar , Kumar Amit , Almutairi Bader O. , Kumar Rupesh
Published: July 2024

Introduction: Anthropogenic disturbances resulting from extensive mining activities in tropical regions pose significant threats to native land use, leading to deforestation, biodiversity loss, climate change impacts, environmental degradation, health risks, landscape fragmentation, compromised ecological security, and societal wellbeing. Monitoring Land Use and Land Cover Change (LULCC) becomes imperative for evaluating the extent and nature of land degradation in mined areas.

Methods: This study examined and compared land cover change patterns across three coalmined sites: Sohagpur (Site-I), Jamuna & Kotma (Site-II), Bishrampur (Site-III) in Central India over 3 decades using Landsat satellite imagery from 1994, 2007, and 2022. The Maximum Likelihood (ML) algorithm, within a supervised classification framework, was applied to discern mining impacts on decadal land use shifts.

Results and discussion: The analysis revealed that 7.32%–17.61% of forest cover, 5.0%–10% of water bodies, and 3%–5% of agricultural lands were lost due to mining activities, with Site three and Site two experiencing greater losses compared to Site 1. Overall, native land cover diminished by 35% between 1994 and 2022. Indices including Soil Index, Climate Index, Terrain Index, Land Utilization Index, and Vegetation Index were derived to assess land degradation patterns. These indices were integrated using a weighted index model in ArcGIS to generate the Land Degradation Vulnerability Index (LDVI). Vulnerability notably escalated with mining expansion, particularly pronounced at Site 3 (Bishrampur) and lower at Site 1 (Sohagpur). The “extremely vulnerable” class encompassed a substantial area (25%–40%), while the “low vulnerable” class was less than 5% across all sites. This study’s comprehensive analysis aids policymakers, planners, and managers in prioritizing targeted interventions and implementing sustainable land management 175 practices for ecorestoration, aligning with the goal of Zero Net Land Degradation 176 (ZNLD) in coal-mined landscapes.
Precision prognosis of colorectal cancer: a multi-tiered model integrating microsatellite instability genes and clinical parameters
Authors: Wang Yonghong , Liu Ke , He Wanbin , Dan Jie , Zhu Mingjie , Chen Lei , Zhou Wenjie , Li Ming , Li Jiangpeng
Published: July 2024

Background

Prognostic assessment for colorectal cancer (CRC) displays substantial heterogeneity, as reliance solely on traditional TNM staging falls short of achieving precise individualized predictions. The integration of diverse biological information sources holds the potential to enhance prognostic accuracy.

Objective

To establish a comprehensive multi-tiered precision prognostic evaluation system for CRC by amalgamating gene expression profiles, clinical characteristics, and tumor microsatellite instability (MSI) status in CRC patients.

Methods

We integrated genomic data, clinical information, and survival follow-up data from 483 CRC patients obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. MSI-related gene modules were identified using differential expression analysis and Weighted Gene Co-expression Network Analysis (WGCNA). Three prognostic models were constructed: MSI-Related Gene Prognostic Model (Model I), Clinical Prognostic Model (Model II), and Integrated Multi-Layered Prognostic Model (Model III) by combining clinical features. Model performance was assessed and compared using Receiver Operating Characteristic (ROC) curves, Kaplan-Meier analysis, and other methods.

Results

Six MSI-related genes were selected for constructing Model I (AUC = 0.724); Model II used two clinical features (AUC = 0.684). Compared to individual models, the integrated Model III exhibited superior performance (AUC = 0.825) and demonstrated good stability in an independent dataset (AUC = 0.767).

Conclusion

This study successfully developed and validated a comprehensive multi-tiered precision prognostic assessment model for CRC, providing an effective tool for personalized medical management of CRC.
Effect of elevated depressive symptoms during adolescence on health-related quality of life in young adulthood—a six-year cohort study with repeated exposure measurements
Authors: Wiehn Jascha , Kurth Tobias , Ravens-Sieberer Ulrike , Prugger Christof , Piccininni Marco , Reiss Franziska
Published: July 2024

Objectives

Depression is a major contributor of young people's burden of disease. In this study we aim to estimate the effect of elevated depressive symptoms on physical health-related quality of life.

Design

We used self-reported information from the prospective BELLA cohort study, which included adolescents selected from the general population in Germany. The baseline assessment (2003–2006) and the 1-, 2-, and 6-year follow-up waves provide the data basis.

Participants

The baseline study population consisted of 1,460 adolescents between the ages of 12 and 17 who, according to their caregivers, did not suffer from depression.

Variables

The primary outcome, as measured by the physical component score (PCS) of the SF-36 at a 6-year follow-up (range: 0–100), is physical health-related quality of life. The exposure of interest is depressive symptoms, as measured by the Center for Epidemiological Studies Depression Scale for Children (CES-DC) at baseline, 1-year follow-up and 2-year follow-ups (range: 0–60). We dichotomized the exposure into subthreshold (≤15) and elevated depressive symptoms (>15). For the main analyses we considered a cumulative index for elevated depressive symptoms across the three time points (range: 0–3). Considered confounders are sex, age, socioeconomic status, migrant background, social support, anxiety symptoms, physical activity, chronic diseases, and sleeping problems.

Statistical methods

We used multiple imputation to account for missing values. Within each imputed dataset, we applied inverse probability weighting (IPW) to estimate the effect of the cumulative index for elevated depressive symptoms at baseline, 1- and 2-year follow-up on physical health-related quality of life at 6-year follow-up. We derived 95% confidence intervals by bootstrapping.

Results

After adjusting with IPW, the effect of the cumulative index per one unit increase of elevated depressive symptoms on the physical component score was −1.71 (95% CI: −3.51 to −0.04). The adjusted effect estimates of single exposure of elevated depressive symptoms on physical health-related quality of life were −0.83 (95% CI: −3.69 to 1.87) at baseline, −2.96 (95% CI: −4.94 to −0.52) at 1-year follow-up and −1.32 (95% CI: −3.85 to 1.15) at 2-year follow-up.

Conclusion

Findings suggest that elevated depressive symptoms during adolescence decrease physical health-related quality of life in young adulthood.
Air quality prediction based on quantum activation function optimized hybrid quantum classical neural network
Authors: Dong Yumin , Li Feifei , Zhu Tingting , Yan Rui
Published: July 2024

Accurate prediction of air quality index is a challenging task, in order to solve the gradient problem of traditional neural network methods in the time series prediction process as well as to improve the prediction accuracy, the study proposes a hybrid quantum neural network prediction model based on quantum activation function. The model utilizes a quantum classical convolutional neural network to tap into spatial correlations between different time periods and combines it with a quantum activation function so as to better avoid the gradient problem and solve the death RELU problem for better spatial feature extraction, and then uses the long short term memory neural network to capture the observations at different times. Experiments were conducted on different air quality datasets using the model, which proved that the proposed quantum activation function optimized hybrid quantum neural network algorithm showed more remarkable advantages in prediction accuracy than other model algorithms.
The mediating effect of after-midnight use of digital media devices on the association of internet-related addictive behavior and insomnia in adolescents
Authors: Lederer-Hutsteiner Thomas , Müller Kai W. , Penker Matthias , Stolz Erwin , Greimel Elfriede R. , Freidl Wolfgang
Published: July 2024

Background

There is evidence that overexposure to digital media devices (DMD) can not only lead to addictive patterns of internet use, but also cause insomnia symptoms. The aim of this cross-sectional study among adolescents is to provide an estimate of the prevalence of sleep impairments and to explore the mediating role of after-midnight use of DMD between internet-related addictive behavior (IRAB) and insomnia.

Methods

2,712 school students from Styrian schools participated in a population-representative online survey in a supervised school setting in spring 2022. School students were screened using established and validated scales. Data analysis was carried out using multiple imputation, linear multilevel regression and mediation analysis.

Results

Prevalence estimation indicates high proportions of clinically relevant moderate [12.6% (11.3%; 14.1%)] and severe [3.6% (2.9%; 4.4%)] insomnia, with an additional 30.6% (29.0%; 32.2%) at subthreshold level. DMD are typically used after midnight an average of 1.66 (1.58; 1.75) evenings with subsequent school day per school week. Linear multilevel regression analysis shows significant associations for sleep disparities as outcome variable e.g., with generalized anxiety [b = 0.329 (0.287; 0.371)], after-midnight use of DMD [b = 0.470 (0.369; 0.572)] and IRAB [b = 0.131 (0.097; 0.165)]. Mediation analysis shows a mediated proportion of 18.2% (13.0%; 25.0%) of the association of IRAB and insomnia by after-midnight use of DMD [Indirect effect: b = 0.032 (0.023; 0.040), direct effect: b = 0.127 (0.083; 0.170)].

Conclusions

Although the cross-sectional nature of this study limits causal inference, the results indicate a need for policies, which are already in preparation in Styria as part of a respective action plan.
Diversity and heterogeneity of smallholder vegetable farming systems and their impact on food security and income in Malawi
Authors: Nzima Wisdom Madede , Ip Ryan H. L. , Bhatti Muhammad Azher , Godfrey Sosheel Solomon , Eik Lars Olav , Gondwe Sera Rose , Divon Shai André
Published: July 2024

Household food security and income play central roles in sustainable development at the global, national, and local levels. Smallholder vegetable farming systems are widely regarded as crucial contributors to enhancing household food security and income in the developing world. Comprehensive whole-farm analysis of smallholder vegetable farming systems points out greater diversity and heterogeneity driven by interactions of socioeconomic and biophysical factors such as land profiles, land use, farm assets, enterprise income, off/non-farm activities, and household structure and expenditure. However, three distinct farm typologies exist (Resource and Livelihood Constrained Off-farm Dependent/Supplemented–RLCOD farmers, Resource and Livelihood Abundant and Commercial Oriented–RLACO farmers, and Medium Resources and Livelihoods Constrained Market Oriented–MRLCMO farmers), exhibiting significant differences and variability in structural and functional factors. The production of maize, groundnuts, soybean, and bean crops remains the primary source of livelihood for all farm typologies. Similarly, vegetable production is vital for farmers’ livelihoods in all farm types, yielding more income than food needs. However, both crop and vegetable productivity and production are still low and below the national and potential target across farm typologies. Small-scale irrigation offers one alternative solution in the context of increasing climate change. Small livestock (chickens, goats, and pigs) play a significant role in the livelihood of vegetable farmers despite their low productivity. Disparities exist across farm typologies in available arable and irrigable land, available household labor, capacity to hire additional labor, farm assets, and inputs, as well as participation in off-farm and non-labor-farm activities. While vegetable production and its proportion sold and earned income emerge as critical factors affecting household food accessibility and acquisition, additional factors such as crop production, proportion of crops sold, daily food expenditure, livestock income, and TLU significantly influence household access for different farm typologies, requiring consideration to achieve food security in vegetable farming systems.
Properties Analysis of Hydraulic PTO Output Fluctuation Regulating Based on Accumulator
Authors: Jia Han , Pei Zhongcai , Tang Zhiyong , Li Meng
Published: July 2024

Hydraulic power take-off (PTO) is increasingly favored as energy regulation and transmission system in wave energy converters (WEC), significantly smoothing the inherent randomness and fluctuation of wave energy. This paper designed a novel hydraulic PTO system composition of a double-acting hydraulic cylinder pump and accumulators. The dynamic process sub-division principle in an operating period of the hydraulic cylinder pump and accumulator and the mathematical model for explaining the fluctuations of pressure and flow rate in the hydraulic pump and accumulator circuit by means of the sub-division principle are put forward. The MATLAB/Simulink simulation model used to analyze pressure fluctuation in the hydraulic PTO system is established based on the mathematical model. The numerical results and MATLAB simulation results are mutually verified about the fine analysis of the accumulator smoothing fluctuation in the hydraulic PTO system. The results show that the pressure fluctuation amplitude of a hydraulic circuit is negatively correlated with the accumulator pre-charge pressure and the accumulator volume, and is positively correlated with the operating period of a hydraulic pump. The energy transfer efficiency of the hydraulic PTO system with accumulator fine compensation can be above 90%. The theory and model in this paper will serve as a valuable reference for designing fluctuation compensation parameters in hydraulic systems.
Design and Test of the Electrical System of the All-Electric Subsea Gate Valve Actuator
Authors: Wang Honghai , Liu Guiqian , Zhou Lai , Jia Peng , Yun Feihong
Published: July 2024

To bridge the gap in the research on the control and drive methods of the key equipment of the new subsea production control system, all-electric subsea gate valve actuator, and to solve the problems of the valve control and drive system in the traditional subsea production system, this paper proposed a full-featured and feasible electrical system of the all-electric subsea gate valve actuator containing the control system and the drive system. The key functions were realized, including status monitoring, redundant communication, redundant power supply, redundant drive, and low-power open-position holding. The electrical system is suitable for monitoring and controlling all-electric subsea gate valve actuators with various specifications and is highly integrated, open, efficient, and real-time. The electrical system prototype was developed and successfully tested for several functions. The results showed that the all-electric subsea gate valve actuator electrical system was capable of controlling and driving the actuator, monitoring the status information of the internal and external environment of the system, as well as the power output information of the drive system, and having redundancy features.
Implementing a Multi-Attribute Decision-Making-Based Approach to Evaluate Small Electric Vertical Takeoff and Landing Fixed-Wing Drones with Mission Efficiency
Authors: Bai Zhuo , Zhang Bangchu , Tian Zhong , Zou Shangnan , Zhu Weiyu
Published: July 2024

Evaluating the mission efficiency of various drone configurations under complex, multi-source, and multi-dimensional requirements remains a significant challenge. This study aimed to develop a comprehensive decision support system (DSS) that employs mission efficiency evaluation, probabilistic hesitant fuzzy sets (PHFs), and multi-attribute decision-making (MADM) methods to assess and optimize drone design. In the proposed method, mission efficiency is defined as a composite measure of the flight performance, adaptability, and economic viability required to complete a mission. By designing a “demand–capability–design” mapping approach, this system effectively resolves multi-attribute conflicts in the decision-making process. To demonstrate the proposed approach, a set of small electric vertical takeoff and landing fixed-wing (e-VTOLFW) drones are compared and ranked based on their mission efficiency. The impacts of different mission requirements on drone evaluation are also discussed. The results demonstrate that this model resolves the traditional issue of unclear information flow in drone design. By improving the evaluation criteria, it enhances informed decision making and the robustness of evaluation results in drone design assessments. Additionally, the model is generalizable and can be widely applied to similar fields such as “demand–product design”, improving the understanding and optimization of product performance.