bluuebunny/crossref_metadata_2025 huggingface dataset:
Implication of nano and microplastics in reproduction: understanding oocyte vulnerability
Authors: Bianchi Andrea , Di Emidio Giovanna
Published: January 2025

The widespread environmental dispersion of nano- and microplastics (NMPs) has sparked serious concerns about their potential impact on human and animal health. NMPs are the result of plastics breaking down due to various chemical, physical, and biological processes. Numerous studies have identified and confirmed the harmful effects of NMPs on the female reproductive system. Specifically, NMPs trigger apoptosis and pyroptosis in granulosa cells by activating the NLRP3/caspase pathway and disrupting the Wnt signaling pathway. These processes contribute to uterine fibrosis and reduce the number of ovarian follicles. Additionally, some research suggests that NMPs may impair oocyte maturation, reduce oocyte quality, and compromise overall ovarian function. This review aims to synthesize the currently limited knowledge on the effects of NMPs on granulosa cells and oocytes. KEY WORDS: Nano-microplastics (NMPs), oocyte, granulosa cells, oxidative stress, inflammation, apoptosis.
Understanding Baseless Self-Knowledge
Authors: Roessler Johannes
Published: January 2025

In seinem Buch Transparency and Reflection entwickelt Matthew Boyle eine ‘transfor­ mative’ Theorie des Selbstbewußtseins. Selbstbewußtsein ist ein wesentlicher Aspekt unserer mentalen Zustände— nicht etwas das zu einer Psychologie hinzukäme, die wir mit nicht-selbstbewußten Subjekten teilten. In seinen jüngsten Veröffentlichungen hat Boyle dieses transformative Model allerdings um eine interessante ‘additive’ Dimension erweitert: während ‘nicht-positionelles’ Selbstbewußtstein unseren mentalen Zuständen wesentlich ist, wird die Fähigkeit zur Reflexion als zusätzliche Leistung verstanden. Der Artikel konzentriert sich auf zwei kritische Fragen: eine zur Kohärenz und eine zur Motivation des additiven Elements der Boyleschen Theorie.
DIE INTELLIGENTE ORGANISATION
Authors: Lambertz Mark
Published: January 2025

In Zeiten zunehmender Dynamik erkennen immer mehr Unternehmen, dass das tayloristische „Command & Control“ nicht mehr funktioniert. Auch die Reduktion auf Teal Organisations oder Holokratie und andere Kochrezepte bringen keineswegs die erhofften Erfolge. Wir müssen erkennen, dass wir in komplexen Systemen agieren, nicht alles wissen und nicht alles in unserem Sinn steuern können. Doch wie können wir den Herausforderungen komplexer Systeme dann begegnen? Wie entwickeln wir ein Gesamtkonstrukt, das es erlaubt, das Große und Ganze zu sehen und uns nicht in punktuellen Einzelmaßnahmen zu verlieren? Lambertz’ neues Buch gibt Antworten auf genau diese Fragen. Es liefert eine vollkommen neue Sichtweise auf Organisationen, die es ermöglicht, Normen, Strategie, Taktiken und Wertschöpfung im Zusammenhang zu verstehen. Denn erst daraus lassen sich die Fähigkeiten des Unternehmens identifizieren und bestmöglich entfalten: Die Symbiose von notwendiger Selbstorganisation mit ebenso notwendiger Führung. Lambertz’ Neuinterpretation des Viable System Model lädt in Form eines Playbooks zum Mitdenken und Experimentieren ein und zeigt an vielen Praxisbeispielen, wie man sein eigenes Modell für die jeweilige konkrete Situation erstellt. Das Denkwerkzeug für die Organisationsentwicklung.
Agiles Führen
Authors: Puckett Stefanie , Neubauer Rainer M.
Published: January 2025

Agiles Führen gilt als das Wundermittel schlechthin. Kaum eine Führungskraft kommt an dem Thema vorbei. Dennoch ist dieses Thema vielerorts nicht mehr als ein Schlagwort. Leider – denn agiles Führen kann sich jede Führungskraft aneignen und anwenden. Was bedeutet agiles Führen im Kontext der digitalen Transformation? Wie verändert sie die Führungsaufgabe? Wie entwickelt man eigentlich agile Führungskompetenz im Alltag? Und wie wird man zum agilen Change Manager? Neubauers und Pucketts Buch gibt Antworten auf diese Fragen. Es wirft einen Blick unter die Oberfläche und zeigt, welche Kompetenzen und Persönlichkeitseigenschaften agile Führungskräfte auszeichnen. Dabei hat es beide Seiten im Blick. Denn agile Führung muss authentisch sein und scheitert allzu oft am Widerstand der Mitarbeiter. Pragmatisch zeigt das Buch, wie sich diese Widerstände auflösen lassen und die Transformation der Organisation gelingt. Auf Basis jahrzehntelanger Arbeit mit Führungskräften und eines wissenschaftlich untermauerten verhaltensorientierten Kompetenzmodells ist dieses Buch entstanden. Es lenkt den Blick darauf, wie wir mit agiler Führung unsere vorhandenen Stärken, Kompetenzen und Erfahrungen zukunftsfähig machen.
contra!
Authors: Zeppezauer Iris
Published: January 2025

Egoismus und Intoleranz sind weitverbreitet. Verbale Attacken, um andere lächerlich oder gar mundtot zu machen, sind beliebte Praxis. Doch wer beruflich und privat Position beziehen will, kann nicht dauerhaft jede Konfrontation vermeiden, Angriffe ignorieren und die eigenen Ziele aufgeben. Aber wie beantwortet man solche Attacken, ohne sich auf das Niveau des Angreifers zu begeben? Wie senkt man die Angst vor der Breitseite und der eigenen Sprachlosigkeit? Wie kontert man mit Leichtigkeit? Antworten darauf liefert Zeppezauers neues Buch. Gekonnt illustriert es, wie wir Angriffe und Motive durchschauen, die Schockstarre überwinden und angemessen kontern. Anstatt auf aggressive, laute Kommunikationsmuster zu setzen, zeigt dieses Buch, wie wir situativ passend, selbstbewusst und kraftvoll unsere Botschaft platzieren – und so unsere Ziele leichter erreichen.
Führung mit Pfiff
Authors: Werner Torsten
Published: January 2025

Die Geschwindigkeit, Komplexität und Ambiguität aller Aufgaben, die Digitalisierung und der Fachkräftemangel führen in vielen Führungsetagen zu hoher Unklarheit und maximalem Stress. Dadurch geht Führungskräften oft der Blick fürs Wesentliche verloren. Werners Buch zeigt, wie Führungskräfte den Überblick behalten und die Kontrolle zurückgewinnen: Durch das Verschmelzen von Klarheit und Konsequenz zu einem Prinzip entsteht sofort eine grundsätzliche Ordnung. Eine Ordnung, die es ermöglicht, die wirklich wichtigen Aufgaben zu identifizieren und stets den Überblick zu behalten. Anhand seiner Erfahrungen als Fußballschiedsrichter illustriert er die Leistungsfähigkeit dieses Prinzips und überträgt es auf den Führungsalltag. Ganz ohne komplizierte Theorien zeigt er einfache und vor allem praktikable Lösungsansätze für alle Hierarchieebenen. Führung mit Pfiff ist einfach, klar und konsequent.
Gamification – Präsentationen mit Fun-Faktor
Authors: Garten Matthias
Published: January 2025

Wie lässt sich auf unterhaltsame Weise Wissen und Informationen vermitteln? Wie lassen sich trockene Themen interessanter verpacken und präsentieren? Wie involvieren und aktivieren wir Zuschauer? Mit Gamification! Als wohl eines der ersten Bücher auf dem Markt zeigt Gartens Buch, wie Präsentationen und Vorträge mit Fun-Faktor entstehen: spielerisch, peppig, unterhaltsam und emotional überzeugend. Denn erst mit Humor und Interaktion kannst du Menschen erreichen und für dich gewinnen. Es illustriert, wie du die Elemente Informieren, Unterhalten und Bewegen on- wie offline in deine Vorträge, Workshops, Seminare, Workshops, Vertriebsgespräche oder großen Town Hall Meetings integrierst. Mit dieser praktischen Toolbox liefert dir neben spielerischen Elementen, Formaten und Settings auch konkrete Case-Studies die Lust auf Umsetzung machen.
Das Design humaner Unternehmen
Authors: Hoffmann-Ripken Bettina , Barrueto Andrea
Published: January 2025

Die Herausforderungen der vierten Industrialisierung, aber auch Konzepte wie New Work und Agilität machen eine umfassende Transformation auf organisatorischer Ebene notwendig. Damit das gelingt, brauchen Unternehmen eine Kultur der Menschlichkeit. Wie kann eine nachhaltige und ganzheitliche Transformation von Organisationen gelingen, die letztlich auch eine Grundlage für agile Arbeitsformen bietet? Was bedeutet es, wenn Organisationen Menschlichkeit zu ihrem Kulturprinzip machen? Wie kann diese Kultur entwickelt werden? Antworten darauf liefert Hoffmann-Ripkens und Barruetos Buch. Es betrachtet die Herausforderungen der Kulturentwicklung in Organisationen im Kontext von Werten, Mindset und Haltung. Gekonnt löst es den scheinbaren Widerspruch zwischen unternehmerischem Interesse und Menschlichkeit auf. Denn Menschlichkeit ist die Basis auf der sich die vielbeschworenen neuen Arbeitsformen erst entfalten können. Mit ihrem Modell der Menschlichkeit liefern die beiden Autorinnen eine Handlungsanleitung, wie konkret und pragmatisch eine Unternehmenskultur entwickelt werden kann, in der Menschen sich sowohl gesehen und wahrgenommen fühlen als auch gefordert und gefördert werden.
A Review on Lignin-Derived Resins for Sustainable Vat Polymerization in Additive Manufacturing
Authors: Obed O’Brien Zakumi , Uthman Taofik Olatunde , Surgun Serdar
Published: January 2025

Additive manufacturing (AM), also known as 3D printing, has emerged as a transformative technology in industrial production, offering unparalleled flexibility and customization in material sciences. Central to the advancement of sustainable AM processes is the exploration of bio-based resins as alternative raw materials to commercially available resin based on epoxides and acrylates produced from petrochemical sources, with lignin emerging as a prominent candidate. Lignin, an abundant organic polymer derived from plant biomass, possesses inherent structural complexity and multifaceted functionalities, making it an attractive alternative to conventional petroleum-based resins. This review delves into the utilization of lignin-based resins for vat polymerization, a key AM technique, with a focus on lignin’s chemical structure, extraction methods, and modification of lignin active sites. By elucidating recent advancements in lignin chemistry and material sciences, this article highlights the utilization of lignin in the formulation of lignin resin for vat polymerization in AM, emphasizing the importance of lignin’s chemical modification to enhance resin properties and printing performance. Through a comprehensive analysis of current research trends and future prospects, this review highlights the pivotal role of lignin in advancing sustainable AM and offers insights into potential avenues for further exploration in the field of material sciences.
Building the Analytics Hierarchy Process (AHP) Framework
Authors: Folorunso Esther
Published: January 2025

This chapter lays the groundwork for the Analytic Hierarchy Process (AHP) by guiding readers through the construction of a robust hierarchical structure. A clear problem definition and desired outcomes are emphasized as the foundation for a successful AHP process. The chapter explores how these elements help create structured objectives, providing a clear understanding of the AHP methodology. The heart of AHP lies in creating a hierarchy that examines decision components and their interrelationships. Readers will learn to identify and break down criteria, ultimately defining alternative solutions. This chapter offers a comprehensive guide to building an AHP framework, providing practical insights into problem definition, criteria selection, and hierarchy construction. It includes a step-by-step approach to creating a well-structured AHP model, techniques for stakeholder engagement, and methods for ensuring consistency in decision-making. By the end, readers will be able to transform complex decision-making challenges into manageable frameworks, leading to accurate comparisons and well-informed conclusions. This chapter not only guides practitioners but also underscores AHP’s versatility through a detailed case study. By embracing AHP’s rigorous prep work and analytical discipline, organizations can achieve superior decisions aligned with their strategic goals and operational realities.
Impact of AI Tools in Tourism: Transforming the Industry
Authors: Thiruthanigesan Kanagasabai , Thevarajan Swampillai Aravinth , Nagendrakumar Nagalingam
Published: January 2025

Artificial Intelligence (AI) tools have increasingly become a transformative force within the tourism industry which is revolutionizing how services are delivered and consumed. This chapter explores the multifaceted impact of AI on the tourism sector, examining its role in enhancing customer experiences, operational efficiency, and safety. The integration of AI technologies such as Natural Language Processing (NLP), Machine Learning (ML), Computer Vision (CV), and predictive analytics is reshaping the way travelers interact with desired destinations and service providers. AI-driven innovations like chatbots, personalized recommendation systems, and smart infrastructure drive a new era of customized and efficient travel experiences. Adopting AI also presents challenges, including privacy concerns, potential biases, and ethical considerations. This chapter delves into these challenges and discusses how AI can contribute to sustainable tourism practices, ultimately offering insights into the future trends and innovations that will continue to shape the tourism industry in the Generation AI era.
Digital Capabilities of Mexican Entrepreneurs: A Policy Analysis
Authors: Barbara Mungaray Moctezuma Ana , Guadalupe González López Angélica
Published: January 2025

This chapter analyzes the factors and digital capabilities that impact the likelihood of becoming an entrepreneur in Mexico. Based on data obtained from the Digital Skills Profiler of the Ministry of Economy for the year 2021, we constructed a digital skills indicator divided into two levels: basic and advanced. A probit regression model was employed to analyze the probability of having digital skills among entrepreneurs and to explore how these skills influence the likelihood of starting a business. The results show that 94% of entrepreneurs in Mexico possess basic digital skills, with very limited diversification in terms of skills at the subnational level. This result emphasizes a concerning technological gap and reflects a landscape of inequality among entrepreneurs in Mexico. Additionally, our probit model demonstrates that individuals who decide to start a business typically have basic digital skills, while those with advanced skills are underrepresented in this sector. This answers the question: How do digital skills influence the likelihood of becoming an entrepreneur in Mexico? Our research limitations include the lack of longitudinal data to assess trends over time.
Aspects Regarding Vegetation Dynamics in Forests and Meadows in Romania
Authors: Niculescu Mariana
Published: January 2025

Along with climate changes, the expansion of urbanization, the reduction of pastoral practices at the rural level, and the expansion of invasive species, the vegetation, are facing very great threats and pressures. They affect the physiognomy, the floristic structure of the phytocoenoses within the plant communities of forests and meadows with repercussions on habitats and ecosystems. Vegetation dynamics and maintaining the state of conservation of ecosystems are in close correlation with the natural landscape. The complex mosaic landscape characteristic of ancestral rural landscapes ensures, in addition, a sustainable exploitation of natural resources and exceptional biodiversity. In this chapter, we have tried to include important aspects regarding the syndamics of meadows and forest vegetation in several areas of conservation interest in Romania, an integral part of the Balkan region. These data on the evolution of the vegetation in these areas are the result of the studies we have carried out over several years, at the level of different types of ecosystems, habitats, subject to different ecological, climatic, and anthropic factors. These research studies had well-defined objectives in establishing the type, the degree of syndynamics of the vegetation, and the importance of its evolution, in close correlation with the conservative management measures of the entire natural capital.
Protein-Based Biomaterials for Tissue Engineering and Regenerative Medicine
Authors: Yang Bin , Li Na
Published: January 2025

Protein-based biomaterials are increasingly recognized for their pivotal role in tissue engineering and regenerative medicine due to their superior biocompatibility, biodegradability, and bioresorbability. This chapter explores the development and application of protein-based biomaterials that enhance cell proliferation, adhesion, and integration with native tissues to support tissue regeneration. The present book chapter outlines the different types of proteins used as biomaterials and elucidates their mechanisms of action in tissue regeneration. By utilizing advanced fabrication techniques such as electrospinning, 3D bioprinting, and encapsulation and adsorption methods, protein-based biomimetic scaffolds that replicate the extracellular matrix (ECM) can be created and protein-based delivery systems that enhance therapeutic stability and efficacy can be developed. In addition, the present book chapter addresses critical challenges associated with extensive tissue defects, offering promising advancements in protein-based biomaterials fields of tissue engineering and regenerative medicine.
Enhanced-View Totally Extraperitoneal Approach to Retrorectus Ventral Hernia Repair
Authors: Schaeffer August , Lu Richard
Published: January 2025

The field of abdominal wall reconstruction is a rapidly growing field. New methods of hernia repair are being developed, and multiple platforms, including robotics, are now being used for the treatment of complex hernias. One such novel surgical technique is the enhanced-view totally extraperitoneal (eTEP) approach to ventral hernia repair. Advantages of this technique include dynamic access to the retrorectus space in an extraperitoneal fashion that allows for large mesh overlap in a well vascularized tissue plane. The retrorectus repair has a low rate of recurrence and with the advantages of a minimally invasive approach including decreased postoperative pain and duration of hospitalisation. This chapter provides an outline on patient selection, operative techniques, and postoperative care.
Perspective Chapter: Decoding the Complexity of HLA Genes – The Heart of Modern Immunogenetics
Authors: Mirela Caragea Andreea , Camil Bohiltea Laurentiu , Elena Constantinescu Alexandra , Constantinescu Ileana , Ursu Radu-Ioan
Published: January 2025

HLA (Human Leukocyte Antigen) genes are a cornerstone of immunogenetics, having a significant impact on a wide range of biological processes and pathologies, from immune responses to the evolution of autoimmune and infectious diseases. Modern sequencing technologies, such as Next-Generation Sequencing (NGS), allow for detailed analysis of this complex system, providing unprecedented resolution. By integrating these advanced technologies, research in the HLA field opens new opportunities for personalized medicine, enabling early diagnosis, treatment of autoimmune diseases, transplantation, and immunotherapy. Furthermore, HLA sequencing plays a crucial role in vaccine development and innovative treatments, contributing to public health improvement and patient quality of life. In addition to its medical impact, HLA also plays an important role in anthropology, providing essential insights into human genetic diversity, population evolution, and adaptation to the environment, as well as interactions with pathogens. HLA studies help reconstruct human history by identifying migration routes and evolutionary mechanisms. To fully leverage the potential of HLA in research and clinical practice, bioinformatics and artificial intelligence methods are essential, enabling rapid analysis and interpretation of complex data. Technological advancements continue to transform the field, facilitating the development of new therapeutic strategies and high-precision diagnostics.
Acute Pancreatitis: Nutritional Management
Authors: Argente-Pla Maria , Francisco Merino-Torres Juan
Published: January 2025

Acute pancreatitis (AP) is the most common acute gastrointestinal disease requiring hospital admission. AP is characterized by an inflammation of the pancreas, by the intraglandular activation of pancreatic pro-enzymes and concomitant autodigestion of the acini, usually followed by a total structural and functional restoration of the gland. Acute necrotizing pancreatitis is encountered in 20% of patients with AP, being associated with increased morbidity and mortality, and may require artificial nutrition by enteral or parenteral route, as well as additional interventions (endoscopic, radiological, or surgical). Pancreatitis patients should be considered as patients with moderate-to-high nutritional risk due to the catabolic nature of the disease and the impact on the nutritional status during the development of the disease. All patients with mild or moderate AP should undergo validated screening methods; however, patients with severe AP should always be considered at risk of malnutrition. This chapter includes the latest developments in the nutritional management of acute pancreatitis.
Modern Slavery; the Myth Generated by Migrants or the Socio-Economic Aggression of the Mighty?
Authors: Gilbert Bua Ewi
Published: January 2025

A little over 15 years ago, common understandings of slavery-related only to its historical manifestations. The very great nations and/or empires in the world were built on slaves’ backs, either by military or religious conquests. Lately, though, with the severe forms of exploitation that proliferate the world, slavery is renamed. South-North migrants, Africa-Europe, Asia, and America migratory tendencies have revealed another level of contemporary slavery, with many in disbelief that such could even be happening in their own country and in the open. Many attach this to the migrants. Research in international criminal law and transnational criminal justice points accusing fingers to the unequal distribution and exploitation of the world’s resources, and hence the socio-economic aggression of the great nations. This chapter seeks to demonstrate that migration alone happens as a result of aggression through wars, exploitation, terrorism, and constructive impoverishment of the less developed countries.
Impact of Modern Forestry and Climate Change on Saproxylic Insect Diversity: Is Life in Dead Wood at Risk?
Authors: Hågvar Sigmund , Ødegaard Frode
Published: January 2025

On a world basis, about one-third of forest-living insect species are saproxylic, that is, they depend directly or indirectly on dead wood. They represent many different insect groups, but the highest species numbers are found among Coleoptera, Diptera, and Hymenoptera. Many saproxylic species are red-listed due to the impact of modern forestry. Preserving their high diversity represents a big challenge in today’s conservation work for insects. There is an urgent need to protect the last, deadwood-rich natural forests and to increase the amount and diversity of dead wood substrate in managed forests. We present a case study from boreal forests in Fennoscandia to illustrate how certain measures have been implemented recently to protect, or restore, habitats for saproxylic beetles. In a second case study, we describe the challenge of conserving the unique insect fauna of old, hollow oaks. Climate change can affect saproxylic insects in several ways, directly or indirectly. Summer drought could initiate large-scale forest fires. Wind felling and snow damage may increase, and other tree species could be favored. Such changes will affect the amount and diversity of dead wood substrates. Higher temperatures may favor bark beetle outbreaks and root rot in boreal forests, and the geographical distribution of species may change. The present system of protected forests in Europe is not sufficient for conserving the diversity of saproxylic insects. Stronger initiatives are needed to protect more forests, and increased considerations must be taken in forestry operations.
Role of the Hippocampus in Adaptive Forgetting: A Question of Synaptic Depression?
Authors: Malleret Gaël
Published: January 2025

This chapter examines the often overlooked but crucial role of the hippocampus in forgetting as a fundamental cognitive process. Challenging the traditional view that forgetting represents a failure of memory, it argues that adaptive forgetting is vital for maintaining cognitive efficiency. In addition to its established functions in learning and memory, the hippocampus is proposed to play a central role in adaptive forgetting by selectively eliminating unnecessary information. This process enhances the storage and retrieval of relevant memories, primarily through synaptic mechanisms such as long-term synaptic depression (LTD). LTD has been shown to facilitate the inhibition or removal of outdated information, thus preventing cognitive overload. The chapter also offers a historical perspective on key discoveries that have shaped this understanding.
The Promise of Digital Wellness to Promote Youth Well-Being and Healthy Communities
Authors: Laffier Jennifer , Rehman Aalyia , Westley Madison
Published: January 2025

The chapter explores how digital wellness can enhance youth interpersonal skills and relationships to contribute to their well-being and community wellness. A literature review was conducted to investigate how digital wellness influences individual well-being, mainly through developing interpersonal skills, and how this may, in turn, support community well-being. The findings suggest that digital wellness is vital in enhancing youth well-being by fostering essential interpersonal skills such as emotional intelligence and empathy, addressing key developmental needs, and nurturing positive emotions. This promotion of individual well-being, in turn, promotes community well-being; youth engage with each other in more optimistic, ethical, and inclusive ways. Digital wellness should be explored further as a key skill for healthy interpersonal relationships in a digital age.
From Concept to Commercialization: High-Throughput Optical Modulation Biosensing for Detecting Low Concentrations of Biomarkers
Authors: Burg Shmuel , Margulis Michael , Danielli Amos
Published: January 2025

Rapid, sensitive, and high-throughput detection of biomarkers at low concentrations is crucial for early disease diagnosis. Many sensitive immunoassays use magnetic beads to capture fluorescently labeled targets, but quantifying these targets involves detecting the fluorescent signal from individual beads, which is time-consuming and requires a costly detection system. Additionally, there is often a trade-off between sensitivity, speed, throughput, and ease of use. A new technology, high-throughput optical modulation biosensing (OMB), enables reading a 96-well plate within 10 minutes. In OMB, a cylindrical permanent magnet immobilizes the magnetic beads at the illumination spot. Then, a laser beam is manipulated between the magnetic beads cluster and the background solution, effectively subtracting noise and reducing the need for washing and separation steps, which are usually incorporated in heterogeneous assays. This technology has evolved into a fully automated platform with high sensitivity and throughput, allowing much faster turnaround time and better sensitivity than the state-of-the-art methods, like enzyme-linked immunosorbent assay (ELISA) (for protein detection) and real-time PCR (for RNA/DNA detection). Here, we provide a comprehensive review of this technology, its development, and its applications in rapid, highly sensitive detection of proteins (e.g., human Interleukin-8) and viruses (e.g., SARS-CoV-2).
Fungi Associated with Other Organisms: Diversity, Interactions and Ecological Importance
Authors: Costa Laura Amália Miranda , Sousa Flavia Helena Aires , Carvalho Evelise Leis , Bertazzo-Silva Fernando Augusto , Pinheiro Velloso Jorge Renato , Pinheiro Velloso Marcos André , Lopes Caio Henrique , Galiano Vanielle , Zorzi Ana Flávia , Klotz-Neves Ana Luiza , Putzke Jair
Published: January 2025

Fungi play pivotal roles in ecosystems by forming diverse associations with other organisms, including plants, animals and microorganisms, along with certain bacteria. These interactions range from mutualistic relationships, such as mycorrhizal associations facilitating nutrient uptake in plants, to parasitic interactions causing disease in the hosts. Fungi also engage in commensal relationships, where one organism benefits without harming or significantly benefiting the other. The ecological importance of these associations is profound, influencing nutrient cycling, biodiversity, and ecosystem stability. For instance, lichens, composed of fungi and algae or cyanobacteria, are pioneer species in harsh environments and contribute to soil formation. Understanding the dynamics of fungal interactions with other organisms is crucial for ecosystem management and conservation efforts. Moreover, exploring the molecular mechanisms underlying these associations can offer insights into biotechnological applications, such as agriculture and medicine, harnessing the potential of fungi for sustainable solutions in various fields.
Perspective Chapter: From Avatar Technology to Interactive Holographic Digital Twin
Authors: Iovane Gerardo , Fominska Iana , Sibilio Maurizio
Published: January 2025

The present work discusses developing and applying interactive digital twins and their holographic rendering as new tools to enforce emotional engagement in learning environments and digital museum experiences. In this work, we will demonstrate how a digital twin—an avatar made extremely realistic through the learning of the speaker’s silhouette, facial expressions, gestures, and voice during the model’s learning and construction phase—provides the user with an exceptionally immersive, realistic, and captivating learning experience. The authors first discuss the developments in avatar and digital twin technologies, on the way toward ever more responsive data-driven holographic twins that would mimic human behaviors and reactions while being recorded with real-time emotional responses from museum visitors. The new framework now combines artificial intelligence, holography, and natural language processing to give a customized educational experience while emotionally engaging the viewer through a system that harmonizes third-party solutions, like HeyGen AI to create avatars, which are modeled on real people; the Holo Tube holographic projector to create a 3D digital twin; and Gamma AI to produce content presentations that are highly engaging and visually appealing. The novel methodology introduced can be applied in many domains and reveals the higher potential of digital twins than avatars, for improving educational environments while creating immersive emotionally engaging experiences in museums, thus opening new ways of engaging with cultural heritage.
Radon Risks Evaluation and Application in the Assessment of Tremor-Prone Areas
Authors: Suleiman Arabi Abdullahi , Tukur Zainab , Isa Funtua Idris , Abdullahi Ali Musa , Kurowska Ewa , Suleiman Abdulhamid Musa , Suleiman Murtala Adam
Published: January 2025

In just a time span of 5 years, northcentral Nigeria has experienced about three earth tremors. Public commentators were quick to attribute the tremors to the over-abstraction of groundwater and construction activities in the area. This study sets out to investigate the cause of tremors in the study area and develop a scientifically viable method that predicts areas prone to earth movement in the event of future tremors using integrated techniques (geophysical, hydrogeological, nuclear, and GIS). The results obtained confirmed the incidences of tremors in parts of northcentral Nigeria. Field and other evidence obtained suggest that the tremors were caused mainly by quarry activities in parts of the area. This suggestion was corroborated by results obtained from the surface manifestation of movements, radon in the groundwater, quarry proximity, slope, etc. Also, the study discovered substantial radiological implications associated with radon in groundwater because of earth movement. It also confirmed as baseless the notion of associating the tremors in the area with the over-exploitation of groundwater. Finally, the study came up with a method that predicts areas prone to earth movement in the event of future tremors in the area and categorized them based on their likelihood of experiencing movement as highly likely, likely, and not likely.
COVID-19 Quarantine Fatigue in Adults with Congenital Heart Disease: The Predictive Role of Fear of COVID-19, Depression, and Anxiety
Authors: Hajitabar Nima , Kianimoghadam Amir Sam , Jadidi Sama , Karbalaei Fatemeh , Khajali Zahra , Noori Mohammad , Vafaei Ali , Shirzad Boshra , Shahi Asma
Published: January 2025

Background: The psychological consequences of the COVID-19 pandemic, such as fear of the virus, depression, anxiety, and quarantine fatigue, have become some of the most significant societal challenges of the 21st century due to the widespread nature of the disease. Objectives: This study aimed to examine the predictive roles of fear of COVID-19, symptoms of depression, and coronavirus-related anxiety in quarantine fatigue among patients with congenital heart disease. Methods: The research utilized a descriptive-correlational design. The statistical population comprised all patients with congenital heart disease referred to Shahid Rajaei hospitals and (X-Country) Heart Center. A total of 105 patients were selected using a convenience sampling method. Data collection tools included the Coronavirus Anxiety Scale (CAS), the COVID-19 Fear Scale, the Depression Scale (DS), and the Quarantine Fatigue Scale. Pearson's correlation and multiple regression analyses were employed to analyze the data. Results: The findings revealed significant correlations between fear of COVID-19 (r = 0.52), coronavirus anxiety (r = 0.46), and depression symptoms (r = 0.61) with quarantine fatigue in patients with congenital heart disease (P < 0.01). Conclusions: This study demonstrates that fear of COVID-19, depression, and coronavirus-related anxiety are significant predictors of quarantine fatigue. Interventions focused on addressing the psychological impacts of COVID-19—such as reducing depression, anxiety, and fear—can yield positive outcomes. Such programs can serve as preventative measures to help individuals manage the quarantine fatigue associated with the pandemic.
Impairment of Routine Childhood Vaccination During COVID-19 Pandemic in Southeast Iran
Authors: Sargolzaei Narjes , Sarhadi Saeedeh , Hashemzehi Gamy , Lakzaee Sahar
Published: January 2025

Background: The COVID-19 pandemic has disrupted childhood immunization coverage and increased vaccine misinformation worldwide. Objectives: This study compared on-time vaccination rates among children under five before and during the COVID-19 pandemic in southeast Iran, a region near two polio-endemic countries. Methods: A cross-sectional study was conducted, comparing data from six months before and six months after the onset of the pandemic. The study included all children under five in Zahedan, covering both urban and rural areas. Sampling was performed by census. Percentages of on-time and delayed or missed vaccinations were assessed by vaccine type and residence. Results: Data from 75,863 children were analyzed. The findings showed significant reductions in on-time vaccination, particularly at birth, in both urban and rural areas. The most affected vaccines were the pentavalent, trivalent, and oral polio vaccines. Rural areas experienced lower on-time vaccination rates compared to urban areas, both before and after the pandemic. Conclusions: The COVID-19 pandemic severely disrupted childhood vaccination programs, leading to delays and missed doses, especially for critical vaccines and in rural areas. These findings emphasize the need for targeted interventions to address vaccination gaps and improve coverage in both urban and rural settings.
ÁGUA E CIDADE
Authors: Falcão Zanandra , Ribeiro Botechia Flavia
Published: January 2025

This article investigates the relationships between water and the city, utilizing Urban Morphology as a theoretical and methodological framework. The objective is to identify forms and formal relationships between water shapes and urban design. The theoretical foundation draws from Kropf (2009), Oliveira (2018), Botechia (2017), and Fernandes (2014), emphasizing the morphological process concepts of Conzen (1960) and the contributions of Dias Coelho (2014), which describe transformation, adaptation, and stagnation processes (Conzen, 1960), as well as addition, superposition, and sedimentation (Dias Coelho, 2014). The municipality of Linhares (Espírito Santo, Brazil) known as the “City of Waters”, with 78 lagoons, is the empirical object due to its enriching context. The methodological protocol comprises three stages: theoretical investigation, elementalization of forms, and analysis of formal relationships. This study aims to enhance understanding of morphological processes and relationships between water shapes and urban design, given their historical, environmental, and social significance.
Keywords: Urban Morphology, water shapes, lagoons, urban design.Topic: Urban Morphology

Este artigo investiga relações entre água e cidade, utilizando a Morfologia Urbana como referencial teórico metodológico. Objetiva-se identificar formas e relações formais entre corpos hídricos e traçado urbano. A fundamentação teórica é embasada em Kropf (2009), Oliveira (2018), Botechia (2017) e Fernandes (2014), com ênfase nos conceitos de processo morfológico de Conzen (1960) e as contribuições de Dias Coelho (2014), que descrevem processos de transformação, adaptação e estagnação (Conzen, 1960), além de adição, sobreposição e sedimentação (Dias Coelho, 2014). O município de Linhares (Espírito Santo, Brasil) conhecido como “Cidade das Águas”, com 78 lagoas, é o objeto empírico devido ao contexto enriquecedor. O protocolo metodológico compreende três etapas: investigação teórica, elementarização das formas e análise das relações formais. Este estudo busca ampliar o entendimento dos processos morfológicos e das relações entre corpos hídricos e o traçado urbano, dada sua importância histórica, ambiental e social.
Identifikasi Bahaya Dan Pengendalian Resiko di Area Produksi Penambangan
Authors: Yusril Yusril
Published: January 2025

Mining companies have provided a level of security related to OHS, but there are still work accidents, occupational diseases, fires, explosions, avalanches, and the environment. Thei causei of worki accidentsi is determined byi thei actionsi ofi peoplei whoi doi noticomplyi withi worki safetyi (unsafei actions) and environmental conditions (unsafe conditions). Thei purposei of thisi studyi is to idetermine the potentiali hazardsi in mining activities and control controls in mining activities. This researchi iwas conductedi at PT Bumi Sentosa Jaya, locatedi ini Boedingi iVillage, Lasoloi Islandsi iDistrict, iNorth Konawei iRegency, Southeasti Sulawesii iProvince. The research was conducted usingi the HIRARCi (Hazardi iIdentification, Riski Assessmenti, and Riski iControl) imethod. Data on hazardi and riski controli are processed using the semi-quantitative.The findings were 20 potential hazards, with an incident rating obtained Extremely low 0%, Priority 20%, Medium 65%, Acceptable 15%After controlling the risk, the residual risk obtained is 40%. 60% is acceptable. Control is carried out by hierarchical control, consisting of engineering, administrative, work practices, and control methods.
Stevens-Johnson Syndrome and Erythema Multiforme Induced by Imiquimod 5% Cream
Authors: Salvi Ilaria , Trave Ilaria , Castelli Riccardo , Parodi Aurora , Cozzani Emanuele
Published: January 2025

Introduction: Topical imiquimod is a safe and effective treatment for actinic keratoses, superficial basal cell carcinomas and anogenital warts. The treatment is commonly associated with local inflammatory reactions, while systemic side effects are rare and generally mild. Only few cases of erythema multiforme and Stevens-Johnson syndrome have been described in association with topical imiquimod application. Objective: We present a review of the existing cases of erythema multiforme and Stevens-Johnson syndrome reported in the literature, analyzing the clinical appearance, the histology and the treatment of the lesions. Method: Nine case of erythema multiforme were reported, characterized by cutaneous rash, bullae, crusting, erosive and targetoid lesions, mainly located at the extremities.  Mucosal involvement and systemic symptoms were sometimes present. Results: Three cases of Stevens-Johnson syndrome were associated with topical imiquimod. In all cases, the authors reported targetoid lesions and areas of erosion affecting trunk and limbs, associated with systemic symptoms, and, in 2 cases, to mucosal erosions. Conclusions: We hypothesize a possible role of interferon-γ, a cytokine involved in the pathogenesis of both herpes-associated erythema multiforme and Stevens-Johnson syndrome, which is released in response to the administration of imiquimod.
A munkavállalók megküzdési stratégiáinak és kompetenciáinak vizsgálata a kiégés három dimenziójával
Authors: Szántó Gerda
Published: January 2025

Napjainkban nagy figyelmet kapott a kiégés jelensége. Mentálhigiénés szempontból is elengedhetetlen fontosággal bír a korai feltárása, hiszen az emberi
erőforrás menedzsment legfőbb célkitűzése, hogy a szervezeti és az egyéni célok egyszerre valósulhassanak meg. Erre fókuszálva nagy figyelmet érdemes
fordítani arra, hogy a munkavállalók milyen kompetenciákkal rendelkeznek,
illetve milyen megküzdési stratégiákat alkalmaznak annak érdekében, hogy a
legkiegyensúlyozottabbak lehessenek a munkahelyen.
Kutatásom célja annak vizsgálata, hogy a munkavállalók kompetenciahalmaza hogyan járul hozzá a legmegfelelőbb megküzdési stratégiához, ami a kiégés
legalacsonyabb szintjét eredményezi. A kérdőíves kutatásban 112 fő vett részt,
akik közül mindenki rendelkezik jelenleg aktív munkaviszonnyal. A használt
módszerben megjelenik a Spencer-Spencer-féle kompetencialista, Maslach-féle
Kiégés Leltár, illetve a Folkman és Lazarus-féle Megküzdési Módok Kérdőív.
A legfontosabb eredmények tekintetében fontos megemlíteni, hogy összefüggés
van a kompetenciák erőssége, a használt megküzdési módok, illetve a kiégés
mértéke között, hiszen beigazolódott az a feltételezésem, hogy együttjárás figyelhető meg a kompetenciák, a megküzdési módok és a kiégés között. Vezető
beosztású személyek, illetve nem-vezetők között nem mutatott a minta szignifikáns különbséget.
Analisis Perilaku Masyarakat dalam Pengelolaan Sampah di Kota Padang Panjang
Authors: Wartin Angeli , Syarief Azhari
Published: January 2025

Waste is one form of waste found in the environment. Its source, form, type and composition are strongly influenced by the level of community culture and natural conditions. This study aims to determine community behavior and factors that influence community behavior in waste management in Padang Panjang City. This study used descriptive methods with quantitative and qualitative approaches, primary data collection techniques were carried out by questionnaire. The population in this study were people in Padang Panjang City, 100 respondents were selected to be research informants. The results showed that the community had “Very Good” waste management behavior. Factors that influence behavior, 1) Public knowledge about waste management is “High”. The general behavior of the community in waste management, namely by managing waste at home such as making unique, interesting crafts, and making eco enzyme, disposing of waste to the nearest TPS and burning waste. 2) Waste management facilities and infrastructure are categorized as “High” in 6 urban villages, while the other 10 are “Medium”. Facilities and infrastructure owned or provided by the community and government in Padang Panjang City are in the form of waste collection containers made of wood, cemented TPS, iron to attach garbage, drums or trash cans. 3) Government policy in Mayor Regulation No. 29/2018 encourages community involvement in waste management through education and information. Counseling activities in Padang Panjang City are attended by the community. Several communities and waste bank managers were awarded certificates for their involvement as inspirational figures in waste management.
Generalized K-Fibonacci Sequence of Q- Matrix
Authors: Kumar Nand Kishor , Sahani Suresh Kumar
Published: January 2025

This article explores the generalized K-Fibonacci sequence derived from matrices, extending the classical Fibonacci sequence to matrix representations. The properties and its applications are also described. The interplay of matrix algebra and generalized Fibonacci sequences offers insights into advanced sequence theory.
Fibonacci Polynomials and It’s Generalization
Authors: Kumar Nand Kishor , Sahani Suresh Kumar
Published: January 2025

This article explores the definition, properties, and generalizations of Fibonacci polynomials, providing a comprehensive understanding of their mathematical significance. We have used their Binet’s formula and generating function to derive the identities.
Hypothesis as the Fundamental Basis of the Deduction of Scientific Knowledge
Authors: Tigranyan Gnel , Tigranyan Sona
Published: January 2025

Key words: hypothesis, problem, theory, probable knowledge, reliable knowledge, scientific revolution

The most important condition for the development of science is the experimental application of theoretical knowledge. Sometimes experience disproves even the most solid theoretical system or any of its components. Such theories do not become useless and rejected. At the same time, practically established positions are preserved, and new scientific problems are proposed on the basis of rejected or refuted principles. Their solution involves analysis and justification of the trinity of logical research: problem-hypothesis-theory. Any hypothesis is an assumption about uncertain and unsystematized prior knowledge. A hypothesis becomes reliable from probable knowledge if it is theoretically systematized and practically justified. This process involves putting forward as many hypotheses as possible to solve problems, enriching them with arguments and previously confirmed knowledge. When entering into competition and conflicts, some hypotheses are forced out of the field of research, while others are denied or supplemented. If any hypothesis successfully overcomes the stages of verification and confirmation and does not conflict with other experimentally confirmed scientific and theoretical systems, it becomes valuable and develops into a theory. The process of scientific search for a theory begins again with a hypothesis and goes through all the same stages.
Analisis penerapan sistem akuntabilitas kinerja instansi pemerintah berdasarkan Peraturan Presiden Nomor 29 Tahun 2014 pada Badan Pendapatan Daerah Provinsi Sulawesi Utara
Authors: Ritto Fanesia , Budiarso Novi Swandari , Sardjono Olivia Y.M.
Published: January 2025

The Government Agency Performance Accountability System is a system whose application is used to measure performance against the level of success and failure in programs and activities. In this case, Presidential Regulation Number 29 of 2014 concerning the Performance Accountability System of Government Agencies which is the basis for the regulation on the implementation of SAKIP. In this regulation, the implementation of SAKIP consists of Strategic Plan, Performance Agreement, Performance Measurement, Performance Data Management, Performance Data Reporting, Performance Reporting, and Review and Evaluation. This study aims to determine the suitability of the implementation of SAKIP based on Presidential Regulation No. 29 of 2014 and to determine the level of success and failure of programs and activities that have been determined. The methods used in this study are qualitative descriptive and data collection methods through interviews and documentation. The results of this study show that the implementation of the Government Agency Performance Accountability System at the North Sulawesi Provincial Regional Revenue Agency has been good and in accordance with Presidential Regulation Number 29 of 2014.