bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects on serum protein levels from one bout of high intensity interval training in individuals with axial spondyloarthritis and controls
Authors: Andersson Åsa , Olsson M. Charlotte , Torell Anna , Mogard Elisabeth , Haglund Emma
Published: November 2023

Background
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. With the aim of investigating how levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT, we studied serum from individuals with axSpA and healthy controls (HC).
Methods
Ten participants with axSpA and 11 age- and sex-matched HC performed a single HIIT bout on a cycle ergometer: 4x4 minutes intervals with three minutes active rest in between. Blood samples were taken before and one hour after the HIIT bout. Serum proteins (IL-6, IL-17, IL-18, TNFa, CXCL-10, VEGF-A, BDNF, DKK-1, osteoprotegerin, osteocalcin, osteopontin, BMP-7, CRP) were analyzed with a Luminex system or ELISA. Descriptive data are presented as mean with standard deviation. A two-way ANOVA was used for comparisons.
Results
A main effect from baseline to one hour post HIIT showed that both groups had a significant increase in serum levels (pg/ml) of IL-6: axSpA 2.2 (3.0) to 3.2 (1.8) and HC 0.4 (0.4) to 1.9 (2.0), p = 0.03. VEGF-A (pg/ml) was significantly lower in the axSpA group: 159 (138) vs. HC 326 (184), p = 0.03, but was not affected by the HIIT bout. BMP-7 (ng/ml) increased in both groups after the HIIT: axSpA 61.6 (13.1) to 75.2 (20.0) and HC 64.6 (20.8 to 75.0 (17.8), p < 0.001. For the other proteins analyzed, there were no significant differences in serum concentrations between individuals with axSpA and HC, or within the two groups before and after one bout of HIIT.
Conclusions
One acute bout of HIIT significantly increases the serum concentrations of IL-6 and BMP-7 after 1 hour in both individuals with axSpA and HC.
FUT11 Expression and Its Clinical Significance in Gastric Cancer
Authors: Huang Yanqing , Yang Xiaoying , Wei Mengda , Yang Xi , Yuan Zhenmin , Huang Junjie , Wei Junren , Tian Lei
Published: November 2023

Background: Gastric cancer (GC) is the most common and aggressively invasive malignancy within the digestive tract. Aberrant glycosylation proteins play a critical role in governing the malignancy of cancer cells and are associated with the advancement of multiple cancer forms. This current study aims to offer a more thorough and systematic comprehension of the expression and clinical relevance of FUT11 in GC, specifically focusing on its involvement in the initiation and progression of GC.
Methods: We employ a range of publicly accessible databases, such as the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), to conduct an extensive investigation of FUT11 in the context of GC. Our analysis encompasses assessments of FUT11's expression levels, its influence on survival prognosis, and its clinical significance. In addition, we acquired GC tissue microarray sections from Suzhou Koch Biotech, comprising 75 individual patient cohorts, further to confirm the expression levels of FUT11 in GC tissues.
Results: Data mining and analysis reveal elevated FUT11 expression in GC, independently associated with patient prognosis. Variable immune cell infiltration levels are observed in patients with differing FUT11 expression. FUT11's involvement in cancer pathways, particularly signal transduction, impacts GC onset and progression.
Conclusions: This study reveals a notable rise in the expression of FUT11 in GC tissue. This increase is linked to a poor prognosis and may affect immune regulation. FUT11 may hold value as an immune and targeted therapeutic, presenting a fresh approach to treating GC.
Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms
Authors: Arvidsson Ida , Strandberg Olof , Palmqvist Sebastian , Stomrud Erik , Cullen Nicholas , Janelidze Shorena , Tideman Pontus , Heyden Anders , Åström Karl , Hansson Oskar , Mattsson-Carlgren Niklas
Published: November 2023

Background: Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be improved using entire brain images in deep learning (DL) models compared to using pre-defined brain regions.
Methods: A cohort of 332 individuals with SCD/MCI were included from the Swedish BioFINDER-1 study. The goal was to predict longitudinal SCD/MCI-to-AD dementia progression and change in Mini-Mental State Examination (MMSE) over four years. Four models were evaluated using different predictors: 1) clinical data only, including demographics, cognitive tests and APOE e4 status, 2) clinical data plus hippocampal volume, 3) clinical data plus all regional MRI gray matter volumes (N=68) extracted using FreeSurfer software, 4) a DL model trained using multi-task learning with MRI images, Jacobian determinant images and baseline cognition as input. Models were developed on 80% of subjects (N=267) and tested on the remaining 20% (N=65). Mann-Whitney U-test was used to determine statistically significant differences in performance, with p-values less than 0.05 considered significant.
Results: In the test set, 21 patients (32.3%) progressed to AD dementia. The performance of the clinical data model for prediction of progression to AD dementia was area under the curve (AUC)=0.87 and four-year cognitive decline was R2=0.17. The performance was significantly improved for both outcomes when adding hippocampal volume (AUC=0.91, R2=0.26, p-values <0.05) or FreeSurfer brain regions (AUC=0.90, R2=0.27, p-values <0.05). Conversely, the DL model did not show any significant difference from the clinical data model (AUC=0.86, R2=0.13). A sensitivity analysis showed that the Jacobian determinant image was more informative than the MRI image, but that performance was maximized when both were included.
Conclusions: The DL model did not significantly improve the prediction of clinical disease progression in AD, compared to regression models with a single pre-defined brain region.
Predicting clinical outcomes in a blended care intervention for early psychosis: Acceptance and Commitment Therapy in Daily-Life (ACT-DL)
Authors: Bonnier Rafaël , Beames Joanne , Kiekens Glenn , Aubel Evelyne Van , Schirmbeck Frederike , de Haan Lieuwe , Marcelis Machteld , Gaag Mark van der , Winkel Ruud van , van Therese Amelsvoort , Vaessen Thomas , Reininghaus Ulrich , Lafit Ginette , Myin-Germeys Inez
Published: November 2023

ACT in Daily Life (ACT-DL) is a blended-care Ecological Momentary Intervention that extends ACT into the daily life of individuals, improving psychotic distress, negative symptoms, and global functioning. However, it remains unclear whether ACT-DL works equally for everyone. We investigated whether moderators (i.e., sociodemographic information, personality, and trauma history) determine clinical outcomes in individuals with early psychosis receiving ACT-DL. Seventy-one participants from the INTERACT trial, using ACT-DL, were analyzed. Outcomes included psychotic distress, negative symptoms, global functioning, and psychological flexibility. Using multivariate-multilevel models, we evaluated the effects of sociodemographics, personality, and childhood trauma across baseline, post-intervention, and six- and 12-month follow-ups. Sociodemographic characteristics and personality predicted clinical outcomes. Higher education demonstrated more substantial improvement in global functioning at 6- (B = 7.43, p = .04) and 12-FU (B = 10.74, p = .002) compared to lower education. Higher extraversion showed less improvement in negative symptoms at 12-FU (B = 1.24, p = .01) and more improvement in global functioning at post-intervention (B = 0.39, p = .046) and 6-FU (B = 1.40, p = .02) compared to lower extraversion. Higher neuroticism showed more improvement in negative symptoms at 12-FU (B = -1.59, p = .001) and higher psychological flexibility at 12-FU (B = 8.38, p = .001) compared to lower neuroticism. Our findings suggest that while ACT-DL improves clinical outcomes in individuals with early psychosis, the improvement rate is dissimilar for individuals and predictable by baseline characteristics. If replicated, these findings enable precision medicine approaches in allocating ACT-DL for early psychosis.
WITHDRAWN: Modelling and Analysis of Timed and Coloured Petri Nets Using Linear Formal Series in Dioid Algebra
Authors: Louis Bal dit Sollier , Alain Ourghanlian , Saïd Amari
Published: November 2023

This paper presents a set of important results concerning the definition of Coloured Formal Series (CFS). These series are derived from the classical formal power series found in the tropical algebra, used for the temporal description of timed events graphs dynamics. They are differentiated by their coefficient, which is a colour. This new mathematical framework can be used to describe coloured models. We show that it exists a certain class of coloured formal series realised by Timed Coloured Petri Nets (TCPN), i.e., that each TCPN described linearly in the dioid of CFS has a periodic transfer function. For that, we define a restriction of TCPNs yielding the class of Linear TCPN. We present some trivial examples of how use CFS to describe such models.
Transcriptional changes impact hepatic proteome in autophagy-impaired liver
Authors: Baral Kamal , Joshi Spandan , Lopez Adriana , Mugon Gavisha , Liu Gang , Hinton Cameroon , Mercer Arissa , Bhetwal Bhupal Prasad , Fang Jia , Khambu Bilon
Published: November 2023

Hepatic proteomes are finely regulated by their biosynthesis, extracellular secretion, and intrahepatic degradation. Autophagy regulates the lysosome mediated intrahepatic degradation and regulates the hepatic proteome. Impaired autophagy results in intrahepatic protein accumulation resulting in proteinopathy. Through this study, we aim to determine whether autophagy can also modulate hepatic proteome in a non-degradative manner. With conditional, inducible, and hepatotoxin models of hepatic autophagy impairment, we analyzed the expression status of the overall hepatic proteome by Coomassie brilliant blue (CBB) and Liquid chromatography tandem mass spectrometry (LC/MS). We identified and validated four specific hepatic proteins- Cps1, Ahcy, Ca3, and Gstm1 that were selectively altered in the autophagy-impaired liver. Cps1, Ahcy, and Ca3 protein expressions were dramatically downregulated while Gstm1 protein expression was upregulated in autophagy-impaired livers. Notably, the altered level of these hepatic proteins was not related to impaired autophagic degradation rather it was related to the change in the mRNA transcript level. In addition, persistent activation of nuclear factor erytheroid-derived-2-like 2 (Nrf2) transcription factor due to autophagic impairment transcriptionally regulates the mRNA expression of these hepatic proteins. Out results suggest that autophagy can regulate hepatic protein through non-degradative transcriptional mechanisms by regulating Nrf2.
Abnormal Pollen Development in the Fragaria vesca Mutant fruitless 1
Authors: Slovin Janet P. , Dougherty Laura E.
Published: November 2023

Knowledge of the genes underlying a given trait is highly useful for developing molecular markers for breeding and is the foundation for future genomic crop improvements. The cultivated strawberry, F. ×ananassa, is a valuable horticultural crop. Genome sequencing revealed that of the four diploid strawberry subgenomes contributing to the F. ×ananassa octoploid genome, the woodland strawberry, F. vesca, subgenome is dominant. Thus, F. vesca is an important system for determining gene function and should be used as a source of genetic diversity for F. ×ananassa breeding. Ethyl methanesulfonate mutagenesis of H4 F7-3, an inbred line of F. vesca, resulted in one M2 line that did not produce any strawberries over a 3-year period in the greenhouse. This line was named fruitless 1. The fruitless 1 phenotype results from a single gene recessive mutation. Microscopic characterization revealed that fruitless 1 failed to produce fruit because anthers fail to develop properly before meiosis, resulting in no pollen production. This report of fruitless 1 facilitates further studies of the line.
Massive particle interferometry with lattice solitons
Authors: Naldesi Piero , Polo Juan , Drummond Peter D. , Dunjko Vanja , Amico Luigi , Minguzzi Anna , Olshanii Maxim
Published: November 2023

We discuss an interferometric scheme employing interference of bright solitons formed as specific bound states of attracting bosons on a lattice. We revisit the proposal of Castin and Weiss [Phys. Rev. Lett. vol. 102, 010403 (2009)] for using the scattering of a quantum matter-wave soliton on a barrier in order to create a coherent superposition state of the soliton being entirely to the left of the barrier and being entirely to the right of the barrier. In that proposal, it was assumed that the scattering is perfectly elastic, i.e. that the center-of-mass kinetic energy of the soliton is lower than the chemical potential of the soliton. Here we relax this assumption: By employing a combination of Bethe ansatz and DMRG-based analysis of the dynamics of the appropriate many-body system, we find that the interferometric fringes persist even when the center-of-mass kinetic energy of the soliton is above the energy needed for its complete dissociation into constituent atoms.
Dynamics of parafermionic states in transport measurements
Authors: Nielsen Ida Egholm , Schulenborg Jens , Egger Reinhold , Burrello Michele
Published: November 2023

Advances in hybrid fractional quantum Hall (FQH)-superconductor platforms pave the way for realisation of parafermionic modes. We analyse signatures of these non-abelian anyons in transport measurements across devices with \mathbb{Z}_6ℤ6 parafermions (PFs) coupled to an external electrode. Simulating the dynamics of these open systems by a stochastic quantum jump method, we show that a current readout over sufficiently long times constitutes a projective measurement of the fractional charge shared by two PFs. Interaction of these topological modes with the FQH environment, however, may cause poisoning events affecting this degree of freedom which we model by jump operators that describe incoherent coupling of PFs with FQH edge modes. We analyse how this gives rise to a characteristic three-level telegraph noise in the current, constituting a very strong signature of PFs. We discuss also other forms of poisoning and noise caused by interaction with fractional quasiparticles in the bulk of the Hall system. We conclude our work with an analysis of four-PF devices, in particular on how the PF fusion algebra can be observed in electrical transport experiments.
Impact of money supply and macroeconomic indicators on foreign portfolio investment: Evidence from Vietnam
Authors: Thi Dieu Chi Nguyen
Published: November 2023

This study examines the relationship between money supply, macroeconomic indicators, and foreign portfolio investment in Vietnam. Using the Autoregressive Distributed Lag Model and Stata 17 software to analyze quarterly data from Q1/2007 to Q4/2022, the analysis reveals strong and enduring correlations. An increase in money supply and economic growth positively influences foreign portfolio investment, with the money supply from the previous quarters significantly impacting foreign portfolio investment (P-value < 0.01). However, foreign exchange rates and foreign direct investment negatively affect foreign portfolio investment. Three macroeconomic indicators show significance at 1% and 5%, where gross domestic product positively affects foreign portfolio investment, while foreign exchange rates and foreign direct investment have detrimental impacts. The findings indicate that a 1% increase in gross domestic product leads to a USD 50.426 million increase in foreign portfolio investment, while a USD 1 million increase in foreign direct investment results in a USD 0.025 million decrease. Foreign exchange rates significantly affect foreign portfolio investment, with the potential for reduction through VND devaluation or an increase in the VND/USD exchange rate due to government adjustments. Definitive conclusions about external debt, interest rates, and inflation require additional data and research. The study’s R-squared value is 0.2738, with an adjusted R-squared of 0.1813, explaining 27.38% of future changes in Vietnam’s foreign portfolio investment. These findings have important implications for policymakers, suggesting that expanding the money supply and implementing suitable interest rate policies could enhance foreign portfolio investment attractiveness in the nearest term.
AcknowledgmentThe author would like to thank the board of editors and the anonymous reviewers for their time and suggestions, which were most helpful in improving this article.
A New Dawn for Targeted Cancer Therapy: Small Molecule Covalent Binding Inhibitor Targeting K-Ras (G12C)
Authors: LI Na , Liu Chen-Fu , Zhang Wen , Rao Guo-Wu
Published: November 2023

K-Ras is a frequently mutated oncogene in human malignancies, and the development
of inhibitors targeting various oncogenic K-Ras mutant proteins is a major challenge
in targeted cancer therapy, especially K-Ras(G12C) is the most common mutant,
which occurs in pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer
(NSCLC), colorectal cancer (CRC) and other highly prevalent malignancies. In recent
years, significant progress has been made in developing small molecule covalent inhibitors
targeting K-Ras(G12C), thanks to the production of nucleophilic cysteine by the
G12C mutant, breaking the "spell" that K-Ras protein cannot be used as a drug target.
With the successful launch of sotorasib and adagrasib, the development of small molecule
inhibitors targeting various K-Ras mutants has continued to gain momentum. In recent
years, with the popularization of highly sensitive surface plasmon resonance (SPR) technology,
fragment-based drug design strategies have shown great potential in the development
of small molecule inhibitors targeting K-Ras(G12C), but with the increasing number
of clinically reported acquired drug resistance, addressing inhibitor resistance has gradually
become the focus of this field, indirectly indicating that such small molecule inhibitors
still the potential for the development of these small molecule inhibitors are also indirectly
indicated. This paper traces the development of small molecule covalent inhibitors targeting
K-Ras(G12C), highlighting and analyzing the structural evolution and optimization
process of each series of inhibitors and the previous inhibitor design methods and strategies,
as well as their common problems and general solutions, in order to provide inspiration
and help to the subsequent researchers.
Enhancement in Biological Availability of Vitamins by Nano-engineering
and its Applications: An Update
Authors: Mishra Sadhna , Sahani Shalini , Pandhi Shikha , Kumar Arvind , Mahato Dipendra Kumar , Kumar Pradeep , Khaire Kaustubh Chandrakant , Rai Ashutosh
Published: November 2023

Vitamin nano-engineering has been accomplished by synthesizing various nanostructures
to improve their stability, bioavailability, shelf life, and functioning. This review provides a
detailed description of recent advances in the art of encapsulation with high efficiency through
the use of practical and logistic nano-engineering techniques such as nanofibres, nanogels, nanobeads,
nanotubes, nanoparticles, nanoliposomes, and many other nanostructures. To demonstrate
the interaction of molecules with nano-forms, the bioavailability of several vitamins such as B,
C, E, A, D, and others in the form of nanostructures is explored. This review will provide a thorough
understanding of how to improve bioavailability and nanostructure selection to extend the
utility, shelf life, and structural stability of vitamins. While nanoencapsulation can improve vitamin
stability and distribution, the materials employed in nanotechnologies may offer concerns
if they are not sufficiently tested for safety. If nanoparticles are not adequately designed and
evaluated, they may cause inflammation, oxidative stress, or other unwanted effects. Researchers
and makers of nanomaterials and medication delivery systems should adhere to established rules
and regulations. Furthermore, long-term studies are required to monitor any negative consequences
that may result from the use of nanostructure.
Green Synthesis of a Novel Phytoalexin Derivative: In Silico Profiling, Apoptotic
Induction, and Antiproliferative Activity against MCF-7 cells - From Vineyards to
Potent Anticancer Drug Molecule
Authors: Roy Lairikyengbam Deepti , Kumar Jyotsna
Published: November 2023

Background::

Resveratrol's structural similarity to commercialized anti-breast cancer medications such
as Tamoxifen underlines its potential as a promising option for developing successful anti-breast cancer drugs.
However, the pharmacokinetic issues associated with resveratrol, such as its low bioavailability, have piqued the
attention of researchers in developing novel derivatives.

Methods:

A novel phytoalexin derivative, RsvD1, was successfully synthesized using resveratrol extracted from
green grape peels as a precursor to investigate its anti-breast cancer efficacy on Estrogen receptor (ER) positive
and negative breast cancer cells.

Results:

The comparative analysis revealed that RsvD1 exhibited remarkable radical scavenging ability (IC50 =
2.21 μg/mL), surpassing the control, Trolox (IC50 = 6.3 μg/mL). Furthermore, RsvD1 demonstrated enhanced and
selective antiproliferative activity against ER-positive MCF-7 cells (IC50 = 20.09 μg/mL) compared to resveratrol,
the parent molecule (IC50 = 30.90 μg/mL). Further investigations unveiled that RsvD1 induced apoptosis and
DNA damage in MCF-7 cells, leading to cell cycle arrest at the G0/G1 phase after 24 hours of incubation. RTqPCR
gene expression analysis indicated that RsvD1 down-regulated the CAXII (ER-dependent) genes. In silico
predictions demonstrated that RsvD1 possesses promising potential as a drug candidate due to its drug-like characteristics
and favourable ADMET profile. Moreover, molecular docking studies provided insights into the theoretical
binding mode between RsvD1 and ERα protein.

Conclusion::

The study highlights the therapeutic potential of the synthesized resveratrol derivative, RsvD1, positioning
it as a promising scaffold for developing novel analogues with improved therapeutic properties and selectivity,
specifically targeting ER+ breast cancer cells. Moreover, the compound's non-cytotoxic yet antiproliferative
properties, coupled with its capability to induce programmed cell death and cell cycle arrest, enhance its
potential as a highly effective drug candidate. As a result, this paves a promising path for the development of
innovative and selective inhibitors targeting ER+ breast cancer with enhanced efficacy.
Human DNA Mutations and their Impact on Genetic Disorders
Authors: Samir Safia
Published: November 2023

DNA is a remarkably precise medium for copying and storing biological information.
It serves as a design for cellular machinery that permits cells, organs, and even
whole organisms to work. The fidelity of DNA replication results from the action of hundreds
of genes involved in proofreading and damage repair. All human cells can acquire
genetic changes in their DNA all over life. Genetic mutations are changes to the DNA sequence
that happen during cell division when the cells make copies of themselves. Mutations
in the DNA can cause genetic illnesses such as cancer, or they could help humans
better adapt to their environment over time. The endogenous reactive metabolites, therapeutic
medicines, and an excess of environmental mutagens, such as UV rays all continuously
damage DNA, compromising its integrity. One or more chromosomal alterations
and point mutations at a single site (monogenic mutation) including deletions, duplications,
and inversions illustrate such DNA mutations. Genetic conditions can occur when
an altered gene is inherited from parents, which increases the risk of developing that particular
condition, or some gene alterations can happen randomly. Moreover, symptoms of
genetic conditions depend on which gene has a mutation. There are many different diseases
and conditions caused by mutations. Some of the most common genetic conditions
are Alzheimer’s disease, some cancers, cystic fibrosis, Down syndrome, and sickle cell
disease. Interestingly, scientists find that DNA mutations are more common than formerly
thought. This review outlines the main DNA mutations that occur along the human genome
and their influence on human health. The subject of patents pertaining to DNA mutations
and genetic disorders has been brought up.
An Introduction to the Integration of Systems Biology and OMICS data for Animal Scientists
Authors: Swargam Sandeep , Kumari Indu
Published: November 2023

Systems biology integrates the data of all the omics studies and provides the
avenues to understand the biology of an organism at higher levels like at tissue, organ
or organism level. In the last decade, studies of genomics, transcriptomics, proteomics
and metabolomics have been carried out. Only a limited amount of this big data has
been analyzed, which is mainly focused on the genotype (single nucleotide
polymorphism) level like minor allele frequency, copy number variation and structural
variants. The analysis in transcriptomics is limited to differentially expressed genes and
their ontology. Proteomics is focused on virulent factors, proteins involved in the
disease progression and immunomodulation. However, in the case of livestock animals,
there is a need to develop pipelines for the analysis of the omics data. With the
integration of omics data into systems biology studies, there is a need to develop
algorithms to carry out gene interaction and protein interaction studies and to build
interaction networks. The pathway analysis of a system requires the well-defined
interacting hub and edges of the protein system of an organism. Developing AI-ML
models for drug discovery is required to target the pathogens of livestock animals. In
the present era, the research is moving towards single-cell sequencing of the cells and
tissues to explore the genetic heterogeneity in the micro-environment of the tissue and
spatial biology of the tissue. This chapter will introduce the reader to different aspects
of omics technology and its role in systems biology for better livestock management.
(Re)Pensar a Formação em Mediação: Contributos Nacionais e Internacionais
Authors: Silva Ana Maria Costa , Guiomar Patrícia , Cunha Sílvia , Macedo Isabel
Published: November 2023

O debate sobre a qualidade da mediação e o reconhecimento dos mediadores tem aumentado nos vários continentes e gerado um particular interesse e investimento, tanto por parte de profissionais e associações de mediadores, como por académicos, investigadores e professores. (Re)Pensar a Formação em Mediação: Contributos Nacionais e Internacionais é o título do livro de atas que resulta de um Congresso Internacional realizado no âmbito do projeto europeu LIMEdiat. Este livro amplia e atualiza a discussão sobre a mediação e a formação dos mediadores, oferecendo reflexões e práticas comprometidas com a construção de uma formação de qualidade. O livro estrutura-se em três eixos, cada um deles focados em temáticas específicas e complementares. O primeiro eixo centra-se na formação, qualidade e ética na mediação; o segundo eixo reflete sobre a formação e as competências dos mediadores no século XXI; e o terceiro eixo incide na mediação, educação e transformação social. Este livro oferece perspetivas amplas e contributos multidisciplinares atuais sobre a formação dos mediadores no contexto nacional e internacional, confirmando a pluralidade de abordagens e visões sobre a importância da mediação, da formação de qualidade dos mediadores e do seu reconhecimento profissional nas sociedades atuais.
Determinants Factors Affecting Quality of Financial Statement Information: External Factors as Moderating Variables
Authors: Syafik Mohammad , Setiawan Doddy
Published: November 2023

AbstractThe purpose of this research is to provide knowledge related to the influence of the internal control system, the use of information technology and human resource capacity on the quality of financial statement information with external factors as moderating variables. The questionnaire used to gather the data for this study was distributed to 107 Lamongan district employees who work in the financial industry.  This research proves that the internal control system, utilization of information technology and human resource capacity has a positive and significant impact on the quality of financial statement information. external factors have no influence on the capacity of human resources on the quality of financial statement information. Future studies may select a wider sample, such as the Provincial Government.Keywords:Internal control system, utilization of information technology, human resource capacity and quality of financial report information.
Recent Research and Theory on Market in Sociology; A Semi-Systematic Literature Review
Authors: Firdaus Firdaus , Zusmelia Zusmelia
Published: November 2023

AbstractCurrent studies of market use social science theories and offer new theoretical approaches. This article discusses the latest theories and approaches to analyze the market. This research was conducted with semi-systemic literature review approach. The data is obtained through searching the published article in online scientific journals related to the market. Data analysis was carried out by thematically categorizing the finding and the presented descriptively. The results found two categories of approaches in the study of markets, namely Structural and Performative (consisted of institutional, network, cultural and normative approaches), and an integrative approach (consisted of integration of social forces and neo-institutionalism in sociology). This paper argues that current theories tend to analyze the market towards stability than dynamics, and the market system than the marketplace. Therefore, this paper purpose a suitable theoretical approach to understand market stability, dynamics and the market as a market place and a market system simultaneously.Keywords:Market Place, Market System, Economic Sociology, Sociology of Market
The implementation of graphic motion-based communication technology material learning videos for 3rd grade elementary students
Authors: Hamidah Azmi Fauziah , Firmansyah Feri Hidayatullah , Permana Fahmi Candra , Azizan Ahamad Tarmizi
Published: November 2023

Motion graphic-based learning videos are a digital learning medium that clarifies material, increases student learning independence, can be accessed quickly, and is not limited in time. This study aimed to determine the implementation and feasibility of motion graphic-based learning videos on the material 'Communication Technology' for third-grade students of Luqmanul Hakim Integrated Islamic Elementary School, Bandung City. This research uses the Design and Development (DD) model. This research went through five stages, namely (1) problem identification, (2) Determining goals and solutions, (3) Product design and development, (4) Trials, and (5) Communication. Data collection techniques used were interviews and questionnaires. Two experts are involved in this study: material and media experts. The sampling technique used is saturated sampling. Namely, the total number of grade 3 students is 24 students. The validation results by the material experts showed a percentage of 100% with the qualification "Very Good." In comparison, the results of the confirmation by the media experts showed a rate of 98%, and the effects of student assessments showed that the percentage showed 92.4% with the qualification "Very Good." Based on the results of validation by experts and reviews by teachers and students, it can be concluded that motion graphic-based learning videos are appropriate for use as learning media.
Validity of interactive learning media in computer basics course
Authors: Pratama Muh. Putra , Ruruk Simon , Karuru Perdy
Published: November 2023

This study aims to determine the validity and practicality of interactive media in computer basics courses in the educational technology study program at Universitas Kristen Indonesia Toraja. This type of development research uses the ADDIE research model (Analysis, Design, Development, Implementation, and Evaluation). The results of the validity and practicality tests can be used as a reference for assessing the media that has been developed. This research has conducted a content validity test; the quality of interactive media based on the assessment by teaching material expert lecturers shows an average of 3.77 from a maximum average score of 4.00. Thus, interactive media shows criteria worth using. The results of the media validity test that the quality of interactive media based on the assessment by media expert lecturers shows an average of 3.58 from a maximum average score of 4.00; thus, the module indicates very feasible criteria. The interactive media practicality test results showed that the interactive media developed an average of 3.46 from an average score of 4.00. Thus, the module showed efficient criteria.
Developing augmented reality novel games as English learning media for reading narrative texts
Authors: Khoirunisa Hajar , Floriasti Tri Wahyuni
Published: November 2023

Incorporating augmented reality (AR) into education is increasingly vital for fostering engagement and interactivity, particularly in language learning, where narrative text plays a central role. The objectives of this study were to (1) ascertain the participants' target demands, (2) analyze their English-language learning needs, and (3) create an augmented reality novel game as a teaching tool for narrative text. This research and development project (RD) was conducted. Junior high schoolers were the subjects; they were 15 males and 17 females. This study was done using a 4-D model. Participants were given questionnaires to complete, and an English teacher was interviewed as part of the need analysis. The instruments used to collect the data were the needs analysis questionnaire, interview guidelines, expert judgment rating scale, and student review questionnaire. The result of this study is an augmented reality novel game as English learning media, which was created after taking into account the findings of the needs analysis, professional opinion, and student evaluation. It consists of narrative texts in general and augmented reality books that serve as instances of narrative texts. The developed media's overall average score was 3.65. The created interactive learning multimedia was therefore categorized as suitable. According to the students' review findings, most augmented reality novel games are excellent and appropriate.
Systematic review of multiliteracies skills, multimodal tools to facilitate learning in early childhood classroom
Authors: Yakubu Francis Moodu , Obafemi Kayode Ezechael
Published: November 2023

This systematic review of literature investigates the use of multimodal tools and acquisition of multiliteracies skills to facilitate effective learning in early childhood educational settings. The review covered a total of 15 relevant articles obtained from databases such as ERIC, Education Full Text, PsycINFO, and Web of Science. Having analyzed and synthesized the current evidence, the review provides a significant and valuable insight into the use and acquisition of multiliteracies skills and tools to facilitate learning in early childhood settings. The sole purpose of this review is to add to the body of existing literature in multiliteracies. The study also provides answer to the only research question of the review which was what are the most effective ways to implement multiliteracies and multimodal techniques in the classroom and how early childhood education can benefit from the systematic application of multiliteracies and multimodal learning. The result of the review revealed that, teachers are facing greater challenges than ever in choosing and designing a pedagogy that can engage students in meaningful literacy practices due to the changing literacy needs in the multimedia environment, the changing lifeworld’s of the learners, and the changing dimensions of school literacies. Therefore, the review recommended that policymakers must work to incorporate all multimodal tools and technology into the curriculum, especially for early childhood education. Also, schools and learning centers should provide limitless opportunities in early childhood classrooms and environment to assist, direct, and motivate students to learn.
Influence of health workers’ fear of death on attitudes to end-of-life care: A multicentre survey-based hospital study with Bayesian analysis
Authors: Majumdar Mainak , Paul Benjamin , Dubowitz Julie
Published: November 2023

We conducted a study to assess whether personal fear of death may influence health professionals’ attitudes to the care of dying patients. We found that higher levels of anxiety about the death and dying of others were associated with discomfort starting discussions about end-of-life care, and that the belief that provision of all treatment options should be prioritised over patient discomfort. Whether self-reported attitudes to death and dying of patients affect clinical outcomes needs study. Trials are needed to determine what specific training could reduce fear of death in healthcare professionals and change attitudes to the death and dying of patients.
Role of Molecular Marker RAPD in Determining the Genetic Divergence between Hybrids and Inbreed Lines of Maize Using Full
Diallel Cross
Authors: Abdulhamed Zeyad A. , Abdulkareem Baraa M. , H. Noaman Abdulsamad.
Published: November 2023

Field experiments were conducted during the spring and autumn seasons of
2021in farmer's fields on the right side of the Euphrates River – Ramadidistrict /
the center of Anbar Governorate. In an entire reciprocal program, four inbreds of
maize (Zm1, A119, Syn-33 and A105) were used and introduced to produce 12
single hybrids. The seeds of the parents and the resulting hybrids were planted
according to randomized complete block design (RCBD)at four replications to estimate the heterosis. The reciprocal hybrid Syn-33 x A105 and the reverse hybrid
Syn-33 x A105 were significantly superior. They gave the highest means of grain
yield (215.78, 203.10 g), grain weight (99.74 and 98.56 g), number of grains in
the ear (17.4 and 16.7 grains row-1
) and heterosis (116.01 and 103.32%) in grain
yield respectively. Randomly Amplified Polymorphic DNA (RAPD) technique
and 15 primers were used. The highest genetic divergence was 0.69 between Zm1
and Syn-33 inbreds, while the highest genetic divergence between inbreds and
hybrids was 0.75 between Zm1 inbred and A105 x A119 hybrid.
Keywords: Primer, Heterosis, Genetic, Polymorphic, RCR.
Relation between interferon-gamma gene expression and its serum level with thyroid hormone status and Ferritin level in Iraqi sickle cell anemia patients
Authors: Jasim Mohammed Bushra
Published: November 2023

The hereditary hemoglobinopathy known as sickle cell disease is characterized by abnormal hemoglobin synthesis, hemolytic anemia, and intermittent obstruction of tiny blood arteries. The current investigation aims to study the relationship between interferon-gamma gene expression and serum levels with thyroid hormone status and Ferritin levels in sickle cell anemia patients. Blood samples were collected from 50 patients suffering from SCA and 50 healthy volunteers as a control group. The results of the relation of IFN-γ serum level with T3, T4 and TSH levels showed a positive relationship between IFN-γ serum and TSH levels. At the same time, an inverse association to T3 and T4 levels with high significance also showed high IFN-γ gene expression (10.78 ±5.06 Fold) in the patient group as compared with control (2.079 ±0.52 Fold) at a significant difference, as well as the results found acquire strong positive association between IFN-γ serum level and IFN-γ mRNA expression in the patient group compared with the control group. The current study concluded that there was an inverse association among T3, T4 and IFN-γ serum with high significance, as high gene expression of IFN-γ, and a strong positive association between IFN-γ serum level and IFN-γ mRNA expression. Keywords: IFN-γ, SCA, Ferritin, TSH, T3, T4.
Distribution of Enterotoxigenic E. coli and Enteroinvasive E. Coli
Among Children with Severe Diarrhea in AL Najaf AL Ashraf / Iraq
Authors: Kahtan Jamal Malak , Kadhum Naeem Ahlam , Kadhim Hawraa I.
Published: November 2023

Diarrhea is the second most important disease that causes death in children under 5
years old. This research aimed to investigate the prevalence of Enteroinvasive E.
coli (EIEC) and Enterotoxigenic E. coli (ETEC) associated with diarrhea among
children under 5 years old. One hundred stool samples have been collected from
children under 5 years old suffering from acute diarrhea. All samples are cultured
on MacConkey agar and Eosin Methylene Blue (EMB) to detect Diarrheagenic E.
coli (DEE). DNA extraction was carried out, and PCR technique. It was used for
amplification of the stp gene for the detection of ETEC and the ipaH gene for the
detection of EIEC. The results showed a wide distribution of DEC (45%) among
males and females, where a high percentage of infection occurred among males
(60%) in Compression with females (40%). The Agarose gel electrophoresis results showed that 33% of isolates possessed ipaH, which revealed that these isolates belonged to EIEC. In comparison, 22% of isolates possessed the stp gene,
which revealed that these isolates were belong to EHEC. In conclusion, diarrhea
may be associated with EIEC and EHEC in addition to EPEC.
Keywords: Enterotoxigenic E. coli, Enteroinvasive E. coli, Children with Severe
Diarrhea, polymerase chain reaction PCR
Treatment of shallow and deep white spot lesions with three different mouthwashes evaluated by laser fluorescence (an in vitro study)
Authors: Ali Abdul Hadi Hussein , Faisal Alhuwaiz Akram
Published: November 2023

This research aims to find how three different types of mouthwashes affect the
depth of artificial white spot lesions. Teeth with various depths of white spot lesions were immersed in either splat mouthwash, Biorepair mouthwash, Sensodyne
mouthwash, or artificial saliva (control)twice daily for one minute for 4 weeks and
8 weeks at 37°C. After this immersion procedure, lesion depth was measured using
a diagnosed pen score. A one-way analysis of variance, Dunnett T3 and Tukey's
post hoc α = .05 were used to analyze the testing data. Splat mouthwash enhanced
the WSL remineralization and made the lowest ΔF compared with other mouthwashes in shallow and deep enamel after 4 and 8 weeks of treatment. In the repair
groups, after 4 weeks of treatment, significant recovery was observed in shallow
enamel. Further improvement in shallow WSL after 8 weeks of treatment with biorepair mouthwash was observed compared to Sensodyne and the control group.
Splat mouthwash is more effective than other mouthwashes in remineralizing two
depths of WSLs at different time points.
Keywords: DIAGNOdent pen, Shallow enamel, Deep enamel, white spot lesion.
Can we use ChatGPT for Mental Health and Substance Use Education? Examining Its Quality and Potential Harms
Authors: Spallek Sophia , Birrell Louise , Kershaw Stephanie , Devine Emma Krogh , Thornton Louise
Published: November 2023

Background

The use of generative artificial intelligence, more specifically large language models (LLMs), is proliferating, and as such, it is vital to consider both the value and potential harms of its use in medical education. Their efficiency in a variety of writing styles makes LLMs, such as ChatGPT, attractive for tailoring educational materials. However, this technology can feature biases and misinformation, which can be particularly harmful in medical education settings, such as mental health and substance use education. This viewpoint investigates if ChatGPT is sufficient for 2 common health education functions in the field of mental health and substance use: (1) answering users’ direct queries and (2) aiding in the development of quality consumer educational health materials.

Objective

This viewpoint includes a case study to provide insight into the accessibility, biases, and quality of ChatGPT’s query responses and educational health materials. We aim to provide guidance for the general public and health educators wishing to utilize LLMs.

Methods

We collected real world queries from 2 large-scale mental health and substance use portals and engineered a variety of prompts to use on GPT-4 Pro with the Bing BETA internet browsing plug-in. The outputs were evaluated with tools from the Sydney Health Literacy Lab to determine the accessibility, the adherence to Mindframe communication guidelines to identify biases, and author assessments on quality, including tailoring to audiences, duty of care disclaimers, and evidence-based internet references.

Results

GPT-4’s outputs had good face validity, but upon detailed analysis were substandard in comparison to expert-developed materials. Without engineered prompting, the reading level, adherence to communication guidelines, and use of evidence-based websites were poor. Therefore, all outputs still required cautious human editing and oversight.

Conclusions

GPT-4 is currently not reliable enough for direct-consumer queries, but educators and researchers can use it for creating educational materials with caution. Materials created with LLMs should disclose the use of generative artificial intelligence and be evaluated on their efficacy with the target audience.