bluuebunny/crossref_metadata_2025 huggingface dataset:
Control Strategy of Thyristors Switched SVCs with High Power Quality
Authors: Panfilov Dmitry Ivanovich , ElGebaly Ahmed , Rozhkov Alexander Nikolaevich , Astashev Michael
Published: December 2018

In this paper, new static VAR compensators SVCs schemes for inductive and capacitive reactive power are developed. The provided schemes improve the flexibility and power system quality of SVCs by developing new circuit topologies with new control strategy of the reactive power. New circuit schemes are introduced for thyristors switched reactors TSR and thyristors switched capacitors TSC to design harmonic-free SVC with higher discrete number of reactive power levels. This paper provides the control algorithm and block diagram of the new SVCs schemes. The switching strategies of TSR and TSC are described and implemented. The new scheme of TSC requires special modifications to decrease transient effects and implementation of specific switching strategies to acquire SVC with high power quality indexes.
Machine learning in diachronic corpus phonology: mining verse data to infer trajectories in English phonotactics
Authors: Baumann Andreas
Published: December 2018

Machine learning is a powerful method when working with large data sets such as diachronic corpora. However, as opposed to standard techniques from inferential statistics like regression modeling, machine learning is less commonly used among phonological corpus linguists. This paper discusses three different machine learning techniques (K nearest neighbors classifiers; Naïve Bayes classifiers; artificial neural networks) and how they can be applied to diachronic corpus data to address specific phonological questions. To illustrate the methodology, I investigate Middle English schwa deletion and when and how it potentially triggered reduction of final /mb/ clusters in English.
An Exploratory Analysis of the Prevalence of Quantitative Research Concepts in Journal Articles
Authors: Hochbein Craig , Smeaton Katherine S.
Published: December 2018

The purpose of this study is to explore the prevalence of quantitative researchmethodologies in published journal articles to better understand the knowledge andskills necessary for school leaders to meet the expectations of applying research findingsto practice. It examines research articles published between 2008 and 2013 inthe American Educational Research Journal, the Educational Administration Quarterly,and the NASSP Bulletin. Empirical articles comprise 91 percent of the 449 identifiedresearch articles, with 58 percent reporting the use of quantitative methodolog.
Wyposażenie obszarów wiejskich w systemy odprowadzania ścieków na przykładzie gmin powiatu olsztyńskiego
Authors: Witkowska-Dąbrowska Mirosława
Published: December 2018

W artykule zaprezentowano zmiany stanu wyposażenia obszarów wiejskich powiatu olsztyńskiego ziemskiego w systemy odprowadzania ścieków bytowych, ze szczególnym uwzględnieniem przydomowych oczyszczalni ścieków. Dane pochodziły z zasobów GUS-BDL. Obliczono udział ludności korzystającej z wodociągów i kanalizacji oraz zaprezentowano liczbę komunalnych oczyszczalni ścieków. Dane dotyczące przydomowych oczyszczalni ścieków i zbiorników bezodpływowych przeanalizowano na 1000 mieszkańców oraz na 100 km2 powierzchni. W wyniku przeprowadzonych badań stwierdzono, że wyposażenie w systemy odprowadzania ścieków rośnie. Szczególnie korzystnie rośnie liczba przydomowych oczyszczalni ścieków i nie spada liczba bezodpływowych zbiorników. Jest to wynikiem rosnącej liczby gospodarstw domowych i mieszkańców zwłaszcza w gminach otaczających Olsztyn.
Implementacja procedury analitycznej hierarchizacji (AHP) do określenia rankingu pilności scaleń gruntów rolnych na przykładzie gminy Jasionówka
Authors: Tekień Tomasz
Published: December 2018

Artykuł podejmuje problem merytorycznego wsparcia w procesie zapobieżenia powstawaniu wadliwej struktury obszarowej gospodarstw rolnych. Zachodzące w ciągu dziesięcioleci zmiany struktury obszarowej i własnościowej gruntów użytkowanych rolniczo, spowodowały ich nadmierne rozdrobnienie, które utrudnia prawidłowe i wydajne gospodarowanie. Na przykładzie gminy Jasionówka (woj. podlaskie, powiat moniecki), zaproponowano wykorzystanie procedury analitycznej hierarchizacji (AHP) jako możliwości ustalenia kolejności przeprowadzenia scaleń w poszczególnych obrębach ewidencyjnych badanej gminy. Pozwala to na racjonalne wykorzystanie ograniczonych środków finansowych przy realizacji kosztownych prac scalenia i wymiany gruntów.
Bullying Prevention in a Swedish Municipality: Supported Decentralised Reasoning
Authors: Larsson Paula
Published: December 2018

The national context of Sweden is particularly illustrative for international research, in that bullying and degrading treatment have been a central aspect of policy-making for some time. In Sweden, schools and municipalities are obliged to produce detailed action plans to counteract bullying. The aim of this study is to describe and analyse how practitioners in schools, during implementation of the Municipality Bullying Prevention Model (MBPM), change the way they work and apply decentralised reasoning to prevent bullying. This study makes use of an action-research approach. In the project, bullying prevention is addressed by the participating schools. The findings indicate that practitioners introduced various measures in different places and at different levels during implementation of the MBPM. It also became apparent that bullying prevention work needs to build on a school’s contextual knowledge and have a whole-school approach.
Analisis Buku Dongeng Si Kancil Karya Tira Ikranegara dalam Peningkatan Nilai Moral
Authors: Wibowo Imam Setyo , Budiman Muhammad Arief , Untari Mei Fita Asri
Published: December 2018

Penelitian ini bertujuan untuk mengetahui apa saja nilai moral yang terkandung dalam buku dongeng si Kancil.Tujuan yang hendak dicapai dalam penelitian ini adalah untuk menganalisis dan mendeskripsikan nilai moral yang terkandung dalam buku Dongeng Si Kancil karya Tira Ikranegara.Jenis penelitian ini adalah penelitian kualitatif, karena dalam menyimpulkan materi hasil analisis menggunakan kata-kata bukan dengan menggunakan angka, sedangkan tehnik pengumpulan datanya melalui analisis data. Setting penelitian ini yaitu di SDN 1 Kandangrejo. Metode pengumpulan data yang digunakan yaitu dengan melakukan wawancara kepada guru dan orang tua/wali siswa, mengedarkan angket kepada siswa yang didalamnya terdapat beberapa pertanyaan untuk siswa, dan dokumentasi yang diambil dari buku yang dianalis.Berdasarkan hasil penelitian menunjukkan terdapat nilai-nilai moral yang terkandung dalam buku Dongeng Si Kancil karya Tira Ikranegara ini, diantaranya seperti seperti sikap hormat, tanggung jawab, kejujuran, keadilan, toleransi, bijaksana, disiplin, suka menolong, berbelas kasih, kerja sama, berani dan demokratis. Nilai moral tersebut terwujud melalui cara mereka bercakap- cakap, serta melalui tindakan-tindakan yang dilakukannya.
The Role of Teachers in Building National Character Values through Traditional Games for Elementary School Students
Authors: Nurfaidah Siti Sholiha
Published: December 2018

Rapid technological and information developments have impacted changes in various lines of life. The big impact that arises from the changes that occur is the decline in the values of the nation's character. The problem solving effort is by providing guidance in improving the ability of educators in shaping the values of the national character of elementary school students. The targets in this activity are the Teacher Working Group (KKG) in SD PBI and KKG in SDN 208 Luginasari. The method used in the form of organizing seminars and workshops on the role of teachers in building national character values to elementary school students. The activity was carried out quite well. Teachers are given debriefing and skills to carry out learning activities that contain character education through traditional game intermediaries. Suggestions for the achievement of the objectives of this activity is that assistance is still needed for the teacher so that the teachers can consistently transform their knowledge and skills in the path that we all expect.
A obesidade como fator associado ao óbito causado por complicações tardias a procedimentos cirúrgicos
Authors: Gonçalves Rafael Valério , Moreira Henrique Morávia Andrade Santos , Faria Mariana Gomes , Fonseca José Otávio Penido , Machado Carla Jorge
Published: December 2018

Objetivo: Avaliar as taxas de mortalidade e o perfil de óbitos com menção, na declaração de óbito, de “obesidade” e “reação anormal ou complicação tardia, por procedimentos médicos, sem menção de acidente ao tempo do procedimento”, causas consideradas evitáveis. Método: Estudo transversal de óbitos de 2004 a 2014, de residentes de Minas Gerais, obtidos no DATASUS com as causas mencionadas. Realizaram-se estudos descritivos e os testes t de Student, χ2 ou Fisher e Wilcoxon Mann-Whitney. Resultados: Em 2004, o número de óbitos por ambas as causas foi 25 para mulheres e 13 para homens; em 2014 foram 43 (aumento de 72%) e 25 (aumento de 92%), respectivamente. Em 2014 houve predomínio de doenças dos aparelhos circulatório (homens) e digestório (mulheres; aumento de 3 para 10 óbitos). A taxa de mortalidade passou, no período, de 0,19 para 0,32/100 mil para homens (15 a 84 anos); de 0,39 para 0,68/100 mil para mulheres (15 a 79 anos). Para mulheres, houve aumento na proporção de óbitos em ambiente hospitalar (p=0,031). A média de idade desses óbitos variou de 48,4 (DP=15,5) para mulheres em 2014 a 51,4 (DP=14,7) para homens no mesmo ano. Conclusão: A obesidade associou-se ao aumento na taxa de mortalidade. As doenças dos aparelhos circulatório e digestório acompanharam esse aumento. Destacam-se a ocorrência em mulheres antes dos 40 anos e serem causas evitáveis. Mulheres obesas que necessitam de cirurgia requerem atenção especial. É possível que haja associação com cirurgias bariátricas, o que requer novas investigações.
TURİSTİK DESTİNASYONLARDA YEREL HALK VE TURİST GÖZÜNDEN TAŞIMA KAPASİTESİNİN DEĞERLENDİRİLMESİ: ESKİŞEHİR ÖRNEĞİ
Authors: Kılıç İLKER , Seçilmiş Cihan
Published: December 2018

Çalışmanın
amacı Eskişehir’de giderek artan turizm hareketlerinin Eskişehir’e gelen
ziyaretçiler ve yerel halk kapsamında değerlendirilmesi ve bu sonuçlarla
beraber Eskişehir’de sürdürülebilir turizmin sağlanması için çözüm önerileri
geliştirmektir. Araştırma iki bölümden oluşmaktadır. Yerel halkın toplumsal
taşıma kapasitesine yönelik tutumlarını ve ziyaretçilerin psikolojik taşıma
kapasitelerini ölçen iki anket kullanılmıştır. Araştırma kapsamında elde edilen
bulgularda, Eskişehir’in sosyal taşıma kapasitesinin aşılmadığı, yerel halkın
turizmin gelişmesiyle beraber olumlu düşünceler içinde olduğu belirlenmiştir. Ayrıca,
psikolojik taşıma kapasitesinin aşılmadığı ve ziyaretçilerin turizmin gelişmesi
ve kalabalığa ilişkin olumsuz düşüncede olmadıkları gözlenmiştir. Ortaya çıkan
sonuçların Eskişehir turizminin sürdürülebilir plan ve politikaların
oluşturulmasında olumlu bir katkı sağlayacağı düşünülmektedir.
Akademik Disiplin Olarak Gastronomi: Kavramsal Bir Çalışma
Authors: Seyitoğlu Faruk , Çalışkan Osman
Published: December 2018

Bu araştırmada akademik disiplin olma ölçütlerinin yardımıyla gastronominin akademik
disiplin olarak konumu incelenmiştir. Paradigma ve kuramsal alt yapı bakımından
eksiklik, özgün bir araştırma sorusunun eksikliği ve doktora programlarının yaygın
olmayışı gibi olumsuzluklar olsa da üniversitelerde gastronomi bölümlerinin sayıca
artması, lisans ve lisansüstü eğitimlerin yaygınlaşması, akademik dergilerin çoğalması
ve gastronomi alanında bir bilim camiasının oluşmaya başlaması gibi olumlu
gelişmelerin akademik disiplin olma yolunda avantaj sağladığı düşünülmektedir.
Literatürde, gastronomi alanının akademik bir disiplin olarak mevcut durumuyla ilgili
disiplin olma ölçütlerine göre değerlendirildiği herhangi bir çalışmaya rastlanmaması
sebebiyle bu çalışmanın hem ilgili literatüre fayda sağlayacağı hem de ileride yapılacak
çalışmalara ışık tutacağı düşünülmektedir.
Şehir Markası Oluşturma Süreci ve Nevşehir’in Markalaşmasının Değerlendirilmesi
Authors: Eren Duygu , Bozkurt İrem
Published: December 2018

Bu çalışmanın amacı
Nevşehir’in mevcut varlık ve faaliyetlerinin neler olduğunu tespit etmek, bu
varlık ve faaliyetlerin şehir markalaşmasında ne derece etkili ve yeterli
olduğunu belirleyerek Nevşehir’in markalaşma sürecine fayda sağlamaktır. Bu
amaçla bir şehrin marka şehir olması yolunda ön plana çıkarılması gereken
varlık ve faaliyetlerde merkezi eğilim ölçüleri gibi istatistiksel analiz
yöntemleri kullanılmıştır. Nevşehir’in marka şehir olması için sahip olması ve
geliştirilmesi gereken varlık ve faaliyetlerin belirlenmesi amacıyla daha önce
bu konu ile ilgili yapılan çalışmalar ve odak grup görüşmeleri sonucu
oluşturulan bir soru formu kullanılmıştır. Araştırma sonucunda Nevşehir’in
marka şehir olması yolunda sahip olması gereken varlık ve faaliyetlerin şehir
yönetimi ve alt yapı, kültür, tarihi miras ve doğal güzellikler, eğitim ve
spor/aktivite, yatırım ve şehirleşme, üst yapı, gastronomi, konukseverlik ve beşeri
kaynaklar ve ulaşılabilirlik olduğu tespit edilmiştir.
Farklı Müfredat Programlarıyla İngilizce Öğrenen Lisans Turizm Öğrencilerinin İngilizce Öz Yeterlilik İnançlarının Karşılaştırılması
Authors: Unur Kamil
Published: December 2018

Türk turizmi
ağırlıklı olarak aktif dış turizme bağımlı olduğu için turizm sektöründe
çalışanların önemli bir bölümünün yabancı dil bilme zorunluluğu bulunmaktadır.
Bu nedenle Turizm eğitimi veren kurumlar verdikleri akademik ve uygulamalı
eğitimin yanı sıra öğrencilerine en az bir yabancı dil öğretmeyi de
hedeflemektedir. Bu çalışmanın amacı farklı müfredat programlarıyla yabancı dil
(İngilizce) öğrenen öğrencilerin İngilizce öz yeterlilik algılarını
belirlemektir.  Bu amaçla dört farklı
fakülte ve yüksekokulda turizm işletmeciliği bölümünde okuyan 751 öğrenciden
anket yoluyla veri toplanmıştır. 
Araştırma bulguları zorunlu hazırlık eğitimi alan, staj yapan ve yurt
dışında bulunan öğrencilerin İngilizce öz yeterlilik algılarının daha yüksek
olduğunu göstermektedir. Bu nedenle de turizm eğitim kurumlarında yabancı dil
hazırlık eğitiminin zorunlu olması önerilmektedir.
Parameter Optimization, Uncertainty Estimation and Sensitivity Analysis in Hydrological Modeling
Authors: Kherde Rajesh VijayKumar , Sawant Priyadarshi H.
Published: December 2018

This paper describes the application of Monte-Carlo simulations for parameter optimization, uncertainty estimation and sensitivity analysis using hydrological model developed by author [8] for Wardha River basin, Maharashtra, India. The Monte Carlo simulations revealed that the average values of parameters for the local optima of the calibration period seem to give good fit to the data and performance measure (NSE) does not differ significantly from the local optima of the respective calibration years. It is interesting to notice that, if the Monte Carlo simulations are carried out all over again, it generate yet another set of random numbers as realizations of model parameters. However the model objective function (NSE) differs mere by 0.1% by running the new set of realizations and the local optimum parameter values are close to the earlier local optima. It seems that the model structure is in agreement with the ‘‘equifinality’’ or ‘‘non-uniqueness’’ concept as many different parameter sets give good fit to the data. However particular area of the parameter space is observed to be dominant in fitting the available observations, this is in contradiction to Beven’s theory behind rejecting the idea of optimum parameter set.
Data Mining Techniques Applying on Educational Dataset to Evaluate Learner Performance Using Cluster Analysis
Authors: Job Minimol Anil
Published: December 2018

Due to the advancement of technology in this digital era, academic institutions are bringing out graduates as well as generating enormous amounts of data from their systems. Hidden information and hidden patterns in large datasets can be efficiently analyzed with data mining techniques. Application of data mining techniques improves the performance of many organizational domains and the concept can be applied in the education sectors for their performance evaluation and improvement. Understanding the business value of the collected data it can be used for classifying and predicting the students’ behavior, academic performance, dropout rates, and monitoring progression and retention. This paper discusses how application of data mining can help the higher education institutions by enabling better understanding of the student data and focuses to consolidate clustering algorithms as applied in the context of educational data mining.
Application of Big Data and the Internet of Things in Industry 4.0
Authors: Mendes Cleiton R. , Osaki Rapfael Y. , Da Costa Cesar
Published: December 2018

Recent technological developments have altered the working conditions in manufacturing industries. Currently, the term Industry 4.0 is used to describe the fourth industrial revolution that has enabled the digitization of the value chain. This revolution has also enabled the connection of production sites via intelligent information systems, which means that machines can communicate with other machines and products. In addition, more accurate data can be delivered, and information can be processed in real time. However, history says that technological development takes time. The complete adoption and realization of the potential of Industry 4.0 will likely require about 20 years. Our discussion in this paper is based on a particular example of an automation integration platform. To understand the potential of big data and the Internet of Things in manufacturing companies, we investigated the production process of an auto parts company. Currently, data is collected manually and automatically. Other types of data are automatically recorded by an information system. Depending on where in the production process the data is collected, the data are logged and processed using different systems.
The Strategies of NOx Emission Reduction for Diesel Engines
Authors: Nam Cao Dao , Le Van Vang
Published: December 2018

Diesel engines are more efficient than forced ignition engines but due to diffused combustion and work with high air residue levels, burning products contain soot and NOx, pollutants that work Handling it on the road today still has many technical problems. The technology of organizing the combustion of diesel engines directly affects the level of pollution generated. Direct injection diesel engines have a lower fuel consumption than a combustion engine with a separation of about 10% and a lower level of soot emissions when the engine is operating in local loading mode. However, direct injection engines work noisier and generate more pollutants (NOx, HC). Today, this type of combustion chamber is only used for heavy-duty truck engines. Limiting the optimal emission level for diesel engines needs to balance the concentration of the two main pollutants, NOx and soot. Low temperature combustion (LTC) engines need different enabling technologies depending on the fuel and strategy used to achieve combustion of the premixed fuel–air mixture. Controlling the combustion rate is one of the major challenges in LTC engines, particularly in PPCI combustion engine to achieve higher thermal efﬁciency, the desired phasing of combustion timings is essential even at moderate combustion rates. Present chapter describes the combustion control variables and control strategies used for LTC engines. Various methods demonstrated to control the LTC engines can be categorized in to two main strategies: (i) altering pressure–temperature and (ii) altering fuel reactivity of the charge.
Study Effect of Objects Orientation in the Mediums On GPR Signal Reflections Using FDTD Simulation
Authors: Mint Mohamed Mostapha Aye , Alsharahi Gamil , Driouach Abdellah
Published: December 2018

Ground penetrating radar (GPR) is a very effective tool for detecting and identifying objects below the ground surface.  based on  the propagation and reflection of high-frequency electromagnetic waves. The GPR reflection can be affected by many things like the type of objects orientation, their shapes ..ect. The purpose of this paper is to  study by simulation the effect of objects orientation in two different mediums (dry and wet sand) on the GPR signal reflection using Reflexw software which is based on a numerical method known as finite difference in time domain (FDTD).  The simulations that have been realized included a conductor  and dielectric objects. The results obtained have led us to find that the propagation path, the reflection strength and the signal form change with the change of object orientation and nature. To confirm the validity of the results, we compared them with experimental results previously published by researchers under the same conditions.
Herramienta para la simulación del movimiento de un micro robot para aplicaciones médicas a partir de un arreglo de bobinas basadas en Maxwell – Helmholtz. (Herramienta de simulación para navegación de microrobots).
Authors: Muñoz Medina Martin Alonso , Vivas Oscar A. , Riccotti Leonardo
Published: December 2018

Objetivo: Los micro robots pueden ser movidos de varias maneras, una de ellas hace uso de señales magnéticas. Este artículo muestra un sistema de navegación magnético para mover y orientar un micro robot para un eventual uso médico, así como una herramienta gráfica para simular el movimiento de dicho micro robot.Materiales y métodos: El artículo presenta inicialmente el proceso de fabricación de un micro robot a partir de diferentes concentraciones de polvo magnético sobre un polímero, su movimiento experimental utilizando un arreglo de bobinas, y la implementación de una herramienta gráfica que simula dicho movimiento.Resultados: El micro robot fabricado pudo moverse en una pequeña arena experimental, variando su posición y orientación dependiendo de la corriente inyectada a dos bobinas que utilizan el arreglo de Maxwell – Helmholtz. La herramienta gráfica, que fue implementada en Unity 3D, mostró un comportamiento muy similar al real.Conclusiones: La herramienta gráfica probó que puede simular con precisión el movimiento real de un micro robot movido a través de dos bobinas magnéticas que utilizan el arreglo de Maxwell – Helmholtz.
Aislamiento de serovariedades de Salmonella enterica a partir de heces de animales domésticos y silvestres en cautiverio
Authors: Pidone Claudio Luis , Zerpa Corina , Caffer María Inés , Moroni Mirian , Comba Eduardo Rubén
Published: December 2018

Se recolectaron muestras de materia fecal correspondientes a 27 especies de animales en cautiverio pertenecientes al Jardín Zoológico de Mendoza (Argentina), con el fin de encontrar portadores asintomáticos de Salmonella. Las muestras de materia fecal obtenidas con hisopos se sembraron en caldo tetrationato base de Müller-Kauffmann y se incubaron a 43 ºC en baño María durante 24 h. Alícuotas de este medio se sembraron en agar xilosa-lisina-desoxicolato y, finalmente, las colonias desarrolladas se identificaron utilizando pruebas bioquímicas convencionales. Como resultado, se aisló Salmonella serovar Meleagridis a partir de muestras de un oso polar y Salmonella serovar Give a partir de las de un oso pardo y un mono carayá. Ambas serovariedades están asociadas con casos de salmonelosis en humanos.
GESTÃO DE RESÍDUOS DE SERVIÇOS DE SAÚDE
Authors: De Andrade José Henrique , Costa Marcela Avelina Bataghin , Bataghin Fernando Antonio , Soares Thereza Maria Zavarese , Fávero Juliane Angelina
Published: December 2018

O presente trabalho tem como objetivo discutir a gestão dos resíduos de serviços de saúde à luz da regulamentação vigente e das práticas e desafios observados em um Hospital Universitário (HU) do interior do Estado de São Paulo. Os Resíduos de Serviços de Saúde (RSS) fazem parte dos Resíduos Sólidos Urbanos (RSU) e, apesar da sua baixa participação em termos de volume dos RSU, geram elevada preocupação em virtude dos altos riscos à saúde e ao meio ambiente. A fim de atingir o objetivo proposto, foram realizados uma revisão da literatura sobre os temas de interesse e um estudo de caso no setor de logística do HU objeto de estudo. Como principais resultados, observou-se que o HU objeto de estudo adota práticas alinhadas à regulamentação e legislação vigente, cumprindo-as satisfatoriamente, porém apresenta desafios relacionados à segregação dos resíduos, engajamento e conscientização dos envolvidos e melhor estruturação do grupo de trabalho, desafios esses, que, se solucionados, podem contribuir significativamente para a otimização da gestão dos RSS.
MONITORAMENTO EM TEMPO REAL DO ÍNDICE OEE
Authors: Mazur Isis , Rosa Aline , Da Silva Adriano Maniçoba , Tanaka Wilson Yoshio , Zampini Eugênio De Felice
Published: December 2018

Atualmente, a competitividade do mercado exige que as organizações busquem melhorias em seus processos e o OEE (Overall Equipment Effectiveness) tornou-se uma ferramenta importante na busca da eficiência do processo quando combinado com outras tecnologias. Este estudo teve como objetivo investigar o efeito do monitoramento do OEE em tempo real no processo de tomada de decisão em uma empresa. Utilizou-se de uma pesquisa exploratória e o um estudo de caso de uma empresa de fabricação de brinquedos, onde se verificou que a adoção do sistema de monitoramento em tempo real foi importante para a melhoria na tomada de decisões, pois permitiu o monitoramento rápido e dinâmico, bem como a possibilidade de priorizar melhorias nos processos de produção.
Nuclear magnetic resonance metabolic fingerprint of bevacizumab in mutant IDH1 glioma cells
Authors: Mesti Tanja , Bouchemal Nadia , Banissi Claire , Triba Mohamed N. , Marbeuf-Gueye Carole , Cemazar Maja , Moyec Laurence Le , Carpentier Antoine F. , Savarin Philippe , Ocvirk Janja
Published: December 2018

Background

Malignant gliomas are rapidly growing tumours that extensively invade the brain and have bad prognosis. Our study was performed to assess the metabolic effects of bevacizumab on the glioma cells carrying the IDH1 mutation, a mutation, associated with better prognosis and treatment outcome. Bevacizumab is known to inhibit tumour growth by neutralizing the biological activity of vascular endothelial growth factor (VEGF). However, the direct effects of bevacizumab on tumour cells metabolism remain poorly known.

Materials and methods

The immunoassay and MTT assay were used to assess the concentration of secreted VEGF and cell viability after bevacizumab exposure. Metabolomic studies on cells were performed using high resolution magic angle spinning spectroscopy (HRMAS).

Results

mIDH1-U87 cells secreted VEGF (13 ng/mL). Regardless, bevacizumab had no cytotoxic effect, even after a 72h exposure and with doses as high as 1 mg/mL. Yet, HRMAS analysis showed a significant effect of bevacizumab (0.1 mg/mL) on the metabolic phenotype of mIDH1-U87 cells with elevation of 2-hydroxyglutarate and changes in glutamine group metabolites (alanine, glutamate, glycine) and lipids (polyunsaturated fatty acids [PUFA], glycerophosphocholine, and phosphocholine).

Conclusions

In mIDH1-U87 cells, changes in glutamine group metabolites and lipids were identified as metabolic markers of bevacizumab treatment. These data support the possibility of a functional tricarboxylic acid cycle that runs in reductive manner, as a probable mechanism of action of bevacizumab in IDH1 mutated gliomas and propose a new target pathway for effective treatment of malignant gliomas.
Monetary Policy and Export Diversification in Nigeria
Authors: Philip Ifeakachukwu Nwosa , Akinyemi Alao Ajibola
Published: December 2018

This study examined the extent to which monetary policy has influenced export diversification in Nigeria for the period 1962 to 2014. The study employed descriptive and ordinary least squares techniques. The descriptive analysis revealed that the diversification exercise in Nigeria can only be expressed as average.

The regression estimate showed that monetary policy was insignificant in influencing export diversification in Nigeria. The study concluded that monetary policy has not played a fundamental role in enhancing export diversification in Nigeria. The study recommended that monetary policy should be purpose driven towards the achievement of export diversification.

This can be achieved by employing selective-sectoral monetary policy measures in accelerating investment in various non-oil sectors of the economy such as the mining, manufacturing and tourism sectors.
STUDI PENDAHULUAN PENGINDERAAN JAUH DAN SISTEM INFORMASI GEOGRAFIS UNTUK ANALISIS MEDAN SKALA TINJAU DI SEBAGIAN PROVINSI SUMATERA SELATAN
Authors: Setyowati Heratania Aprilia , Nurani Ratna , Santosa Sigit Heru Murti Budi
Published: December 2018

Beragam cara dapat digunakan untuk mengetahui karakteristik suatu wilayah, salah satunya adalah analisis medan yang merupakan studi sistematik yang memanfaatkan data penginderaan jauh untuk menggali asal muasal, riwayat geomorfologi, dan komponen suatu bentang lahan. Tujuan dari studi pendahuluan ini untuk mengetahui karakteristik medan yang ada di sebagian daerah Sumatera Selatan melalui analisis medan dengan pembuatan sekuen medan yang berbasis citra penginderaan jauh. Citra Landsat 8 digunakan untuk mendapatkan informasi tutupan lahan dan bentuk lahan. Citra SRTM (Shuttle Radar Topography Mission) digunakan untuk menghasilkan data DEM (Digital Elevation Model), hillshade, dan slope yang selanjutnya diturunkan menjadi peta topografi. Peta Geologi digunakan untuk menurunkan informasi mengenai jenis tanah. Peta arah aliran dan akumulasi air digunakan untuk menurunkan informasi kondisi drainase. Selanjutnya semua peta dioverlay dan digunakan untuk menarik garis sekuen medan sebagai dasar identifikasi karakteristik medan. Berdasarkan hasil studi pendahuluan ini, dapat dikenali bahwa karakteristik medan sebagian Sumatera Selatan berbentuk lahan vulkanik, struktural dan fluvial dengan proses geomorfologi berupa erosi vertikal, transportasi, deposisi, dan sedimentasi. Aplikasi Penginderaan Jauh dan SIG dengan metode sekuen medan dapat digunakan untuk mengetahui karakteristik medan suatu wilayah.
Faktor-Faktor Yang Mempengaruhi Income Smoothing Pada Perusahaan Manufaktur Periode 2014-2016
Authors: Lukman Suryadi William Sanjaya,
Published: December 2018

The purpose of this empirical research is to examine the effect of firm size, financial leverage, profitability, and cash holding against income smoothing in the manufacturing companies listed on the Indonesia Stock Exchange from 2014-2016. This research uses 63 manufacturing companies that were selected using purposive sampling method for a total of 189 data in three years.In this study, the hypotheses test is performed using the logistic regression model.The results showed that profitability, cash holding and firm size has no effect on income smoothing. Financial Leverage has a negative influence on income smoothing.
Advantage of the subcutaneous immunoglobulin replacement therapy in primary immunodeficient patients with or without secondary protein loss
Authors: Gür-Çetinkaya Pınar , Çağdaş-Ayvaz Deniz Nazire , Öksüz Ayça Burcu , Ertoy Ayşe , Hayran Umut , Özkan Feride , Erol Meliha , Tezcan İlhan
Published: December 2018

In recent years subcutaneous immunoglobulin is widely used for primary immunodeficient patients. Subcutaneous administration provides a more stable and higher serum immunoglobulin levels due to continuous and steady transition from lymphatics to the systemic circulation. We aimed to evaluate the changes in serum immunoglobulin levels under subcutaneous immunoglobulin therapy in patients with primary immunodeficiency with or without secondary protein loss. Nine patients with primary immunodeficiency who switched to subcutaneous immunoglobulin were enrolled. Age, gender, diagnosis, reasons of transition to subcutaneous route, reasons of secondary protein loss were recorded. A questionnaire consisting of frequencies and types of infections, side effects observed with intravenous and subcutaneous routes; date and reason of transition to subcutaneous route were asked to all participants. Serum immunoglobulin levels at the 3rd and the 6th months before and after subcutaneous route were recorded. Of the 9 patients (M/F=4/5) the median age was 12 years (6.1-28.7) and 5 of them had protein loss. In total, 444 injections were applied, and all patients experienced local reactions. Infections were more frequent under intravenous than subcutaneous route (p=0.004). We observed an increase in immunoglobulin levels under subcutaneous route (p=0.069 at 3rd; p=0.13 at 6th month). This increase was evident at the 3rd month of transition to subcutaneous route in patients with protein loss (p=0.080). There was an increase in serum immunoglobulin levels under subcutaneous route. However, increase was not statistically significant since the study group was small. This increment was prominent in patients with protein loss. Subcutaneous administration may be a good alternative for primary immunodeficient patients with protein loss who have persistent low serum immunoglobulin levels despite increments in the intravenous immunoglobulin doses.
Attitudes of physicians concerning vaccines not included in the national immunization schedule
Authors: Çataklı Tülin , Duyan-Çamurdan Aysu , Aksakal-Baran F Nur , Güven Ahmet Enes , Beyazova Ufuk
Published: December 2018

The aim of this study was to identify attitudes of family physicians and pediatricians working in sub-provinces of central Ankara concerning rotavirus (RV), human papilloma virus (HPV), meningococcal conjugate vaccine (MenACWY-MCV4) and adolescent and adult pertussis (Tdap) vaccines which are not included in the National Immunization Schedule (NIS). Questionnaires were conducted with 300 family physicians and 230 pediatricians who were selected by random sampling. RV vaccine is the most commonly recommended vaccine by physicians (60.5%). It is the vaccine they want to be added to the NIS the most (48.5%). Tdap vaccine is the least recommended vaccine (24.1%) and the least preferred for inclusion in the NIS (19.6%). Of the physicians recommending the RV vaccine 94.0% believe that `RV-related diarrhea cases exhibit a severe course of illness in children younger than two years old.` Pediatricians recommend RV, meningoccocal and Tdap vaccines more than family physicians (p < 0.05). Of the physicians who do not recommend RV, HPV, and conjugated meningococcal vaccine 87.5%, 96.7% and 27.6% found the vaccines expenive, respectively. Of the physicians who do not recommend Tdap vaccine 90.4% think that `Tdap vaccination is not a health problem of priority for their country.` In conclusion physicians are recommending vaccines which are not included in the NIS. Their common concern for not recommending these vaccines is expensive price.
Polyarteritis nodosa in case of familial Mediterranean fever
Authors: Gökçe İbrahim , Altuntaş Ülger , Filinte Deniz , Alpay Harika
Published: December 2018

Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent self-limited attacks of fever accompanied by peritonitis, pleuritis, and arthritis. Protracted febrile myalgia syndrome (PFMS) is a rare form of vasculitic disease which is an uncommon dramatic manifestation of FMF, characterized by severe crippling myalgia and high fever. Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis affecting medium or small arteries. It is rarely observed in children, but its incidence increases in the presence of FMF. In this article we described a 14-year-old child diagnosed with FMF associated with PAN. Physicians should be aware of this possible association.
Granulomatous amebic encephalitis caused by Acanthamoeba in an immuncompetent child
Authors: Sütçü Murat , Aktürk Hacer , Gülümser-Şişko Sezen , Acar Manolya , Erol Oğuz Bülent , Somer Ayper , Bilgiç Bilge , Salman Nuran
Published: December 2018

Acanthamoeba may lead to granulomatous amebic encephalitis (GAE) with high mortality rates generally in patients with immunosupression and/or chronic disease. Here, we present a rare GAE case, who was a previously healthy child. A Georgian 9 year old boy presented with focal seizure on his left arm and confusion. Since computed tomography (CT) demonstrated hypodense lesion on right occipital lobe, brain biopsy was performed. Histopathological examination of the biopsy material revealed Acanthamoeba cysts and trophozoites together with granulomatous inflammation. The patient, who had no clinical and laboratory findings consistent with immunedeficiency, was diagnosed as GAE. He was treated with a combination drug therapy. Even if it is very rare, amebic meningoencephalitis may also be seen in immunocompetent children, as in our case. Definitive diagnosis is made by microbiological and histopathological examination of brain biopsy material.
Characteristics of woman`s heart with disorder of coronary circulation
Authors: Actaiyeva Leilim , Abzaliyev Kuat , Abzaliyeva Simbat , Aldangarova Gulum
Published: December 2018

We present review of current evidence on ischemic heart disease in women. The risk factors, clinical manifestations, diagnosis and treatment  and prevention of ischemic heart diseases in women are discussed.
REGULARIZAÇÃO DO CONTORNO GENGIVAL: TÉCNICA DA CIRURGIA GUIADA POR MOCKUP
Authors: CUSTÓDIO Flávia Cristina , OLIVEIRA Mariana Alves de , NOVAES Vivian Cristina Noronha , Rodrigues GUSMAN David Jonathan
Published: December 2018

Introdução: A gengivoplastia é uma técnica cirúrgica que se faz a exérese da gengiva marginal, restabelecendo um aspecto mais harmônico e estático ao sorriso e pode ser utilizado um mockup para guiar-se na incisão. Objetivo: Desta forma, o objetivo desse trabalho é descrever uma gengivoplastia utilizando uma guia cirurgia baseada em mock-up auxiliando o tratamento multidisciplinar nas restaurações indiretas. Relato de caso: Paciente AMCC, 42 anos, queixava-se da coroa clí­nica curta e, com encaminhamento da prótese após fazer mockup para facetas de porcelana. Após os exames periodontais de rotina, foi indicado a cirurgia de gengivoplastia. O mockup foi feito a partir de enceramento para planejamento de facetas, e por meio do mockup foi confeccionada também uma guia cirúrgica e colocado em posição para demarcação dos pontos sangrantes. Com o gengivótomo de Kirkland os pontos foram unidos por meio da incisão de bisel externo. Em seguida foi realizado as incisões na base da papila com o gengivótomo de Orban e removido o colar gengival com curetas universais. Um peeling gengival foi realizado para devolver o aspecto de arco concavo regular. O cimento cirúrgico foi adaptado na região operada para favorecer o processo de cicatrazação e diminuir a dor pós-operatória. Conclusão: Diante dos limites do presente caso clínico, pode-se concluir que a guia cirúrgica a partir do mock-up auxiliou o tratamento cirúrgico ao delimitar com exatidão as incisões da gengivoplastia de acordo com o planejamento das facetas, obtendo-se um aspecto estético para o paciente.
Innovating Provincial Level Succession Planning in Hoa Binh Province
Authors: Hung Ta Huy
Published: December 2018

The public administration sector is currently facing numerous internal challenges (e.g. efficiency, effectiveness in public administration) as well as external challenges (e.g. globalization trends, technological revolution...). In order to overcome those challenges, the public administration sector needs to innovate its succession planning for better quality human resources and particularly senior officials. In this study, the author uses quantitative and qualitative research methodology to evaluate the succession planning of the provincial-level leaders in Hoa Binh Province. Based on the data analysis, the author analyzes shortcomings and limitations and proposes recommendations so as to improve the succession planning of the provincial level leaders in Hoa Binh Province.

Keywords

Succession planning, competence based succession planning framework, innovation of succession planning

References

[1] Jarrell, K. M., & Pewitt, K. C., “Succession planning in government: Case study of a medium-sized city”, Review of Public Personnel Administration, 27 (2007) 3, 297-309.[2] Hồ Chí Minh toàn tập, Tập 5, NXB. Chính trị Quốc gia, Hà Nội, 1995, tr. 229-306.[3] Grimm, J. W., “Effective leadership: Making the difference”, Journal of Emergency Nursing, 36 (2010) 1, 74-77.[4] Yukl, G., Leadership in organizations (5th ed.), Upper Saddle Creek, N.J.7 Prentice-Hall, 2002.[5] Bass, B. M., & Stogdill, R. M., Bass & Stogdill's handbook of leadership: Theory, research, and managerial applications, Simon and Schuster, 1990.[6] Nguyễn Khắc Hùng, Kỹ năng lãnh đạo, NXB. Đại học Quốc gia Hà Nội, 2015.[7] Hướng dẫn số 15- HD/BTCTW về công tác quy hoạch cán bộ lãnh đạo, quản lý theo tinh thần Nghị quyết số 42-NQ/TW ngày 30/11/2004 của Bộ Chính trị (Khóa IX) và Kết luận số 24- KL/TW ngày 05/6/2012 của Bộ Chính trị (Khóa XI).[8] Hướng dẫn số 05 xây dựng quy hoạch cán bộ lãnh đạo, quản lý các cấp nhiệm kỳ 2020-2025 và những năm tiếp theo.[9] website: http://tinhuyhoabinh.vn/chuyenmuc/tabid/235/cMenu1/20/cMenu0/155/TopMenuId/155/cMenu/155/stParentMenuId/20/Default.aspx
2018 Nobel Economics Prize: Integrating Climate Change Measures into Sustainable Economic Growth
Authors: An Nguyen Thi Thuc , Anh Dau Kieu Ngoc
Published: December 2018

The 2018 Nobel Economics Prize was awarded to two American economists - William D. Nordhaus and Paul M. Romer - who designed methods for better assessing environmental issues and technological advances on growth. This year’s Laureates, Nordhaus was the first person to create an intergrated model to assess interactions between society and nature and Romer laid the foundation for what is now called endogenous growth theory. According to the Swedish Royal Academy of Sciences, these two macroeconomists’ research have helped “significantly broaden the scope of economic analysis by constructing models that explain how the market economy interacts with nature and knowledge” which integrates climate change measures into long-term sustainable economic growth.

Keywords

Nobel in economics, William D. Nordhaus, Paul M. Romer, climate change, endogenous growth theory, economic growth

References

[1] Y Vân (2018), “Lý lịch 'khủng' của hai nhà khoa học vừa giành giải Nobel Kinh tế 2018”, Vietnambiz, đăng tải ngày 08/10/2018, https://vietnambiz.vn/ly-lich-khung-cua-hai-nha-khoa-hoc-vua-gianh-giai-nobel-kinh-te-2018-95776.html[2] Jonas O. Bergman, Rich Miller (2018), “Nordhaus, Romer Win Nobel for Thinking on Climate, Innovation”, đăng tải ngày 8/10/2018, https://www.bloomberg.com/news/articles/2018-10-08/nordhaus-romer-win-2018-nobel-prize-in-economic-sciences [3] Antonin Pottier (2018), “Giải Nobel” William Nordhaus có thật sự nghiêm túc?”, Nguyễn Đôn Phước dịch, đăng tải ngày 11/10/2018, http://www.phantichkinhte123.com/2018/10/giai-nobel-william-nordhaus-co-that-su.html[4] Thăng Điệp (2018), “Giải Nobel kinh tế 2018 về tay hai người Mỹ”, đăng tải ngày 8/10/2018, http://vneconomy.vn/giai-nobel-kinh-te-2018-ve-tay-hai-nguoi-my-20181008185809239.htm[5] Lars P. Syll (2018), “Cuối cùng - Paul Romer cũng có được giải thưởng Nobel”, Huỳnh Thiện Quốc Việt dịch, đăng tải ngày 14/10/2018, http://www.phantichkinhte123.com/2018/10/cuoi-cung-paul-romer-cung-co-uoc-giai.html[6] Phương Võ (2018), “Nobel Kinh tế 2018: Chạm tới bài toán khó của thời đại”, đăng tải ngày 9/10/2018, https://nld.com.vn/thoi-su-quoc-te/nobel-kinh-te-2018-cham-toi-bai-toan-kho-cua-thoi-dai-20181008221734228.htm[7] Đông Phong (2018), “Nobel Kinh tế cho giải pháp phát triển bền vững và phúc lợi người dân”, đăng tải ngày 8/10/2018, https://news.zing.vn/nobel-kinh-te-cho-giai-phap-phat-trien-ben-vung-va-phuc-loi-nguoi-dan-post882860.html[8] Thanh Trúc (2018), “Giải Nobel kinh tế 2018: Thay đổi tư duy về biến đổi khí hậu”, https://tusach.thuvienkhoahoc.com/wiki/Gi%E1%BA%A3i_Nobel_kinh_t%E1%BA%BF_2018:_Thay_%C4%91%E1%BB%95i_t%C6%B0_duy_v%E1%BB%81_bi%E1%BA%BFn_%C4%91%E1%BB%95i_kh%C3%AD_h%E1%BA%ADu[9] Cẩm Anh (2018), “Nobel kinh tế 2018: Lời giải cho tăng trưởng kinh tế bền vững”, đăng tải ngày 11/10/2018, http://enternews.vn/nobel-kinh-te-2018-loi-giai-cho-tang-truong-kinh-te-ben-vung-137600.html.
Is Xenophobic Violence and Criminality Systemic in Post-Apartheid South Africa? A Critical Analysis of Growing Denialism to 2015 Incidents
Authors: Mkhize Mbekezeli Comfort , Makau Kongko Louis
Published: December 2018

This article argues that the 2015 xenophobic violence was allowed to spread due to persistent inaction by state officials. While the utterances of King Goodwill Zwelithini have in part fuelled the attacks, officials tend to perceive acts of xenophobia as ordinary crimes. This perception has resulted in ill-advised responses from the authorities, allowing this kind of hate crime against foreign nationals to engulf the whole country. In comparison with similar attacks in 2008, the violent spree in 2015 is characterised by a stronger surge in criminal activities. The militancy showcased fed a sense of insecurity amongst foreigners, creating a situation inconsistent with the countryâ€™s vaunted respect for human rights and the rule of law. Investors lost confidence in the countryâ€™s outlook, owing in part to determined denialism in government circles regarding the targeting of foreigners. While drawing from existing debates, the articleâ€™s principal objective is to critically examine the structural problems that enable xenophobia to proliferate and the (in)effectiveness of responses to the militancy involved in the 2015 attacks. Of particular interest are the suggested responses that could be effective in curbing future violence. The article concludes that xenophobia is systemic in post-apartheid South Africa. Strong cooperation between the government, national and international organisations could provide the basis for successful anti-xenophobia measures. The article further argues that the country is obliged to find a sustainable solution to the predicament for humanitarian reasons firstly, and in recognition of the support South Africans received from its African counterparts during the liberation struggle.
Palliative Care Needs of People Living in a Newly Established Informal Settlement
Authors: De Villiers Martjie , Maree Johanna Elizabeth , Van Belkum Corrien
Published: December 2018

Evidence-based guidance for the delivery of palliative care in Africa is rare. Identifying the palliative care needs of this community could contribute evidence to guide the services provided, and could add to the body of knowledge of palliative care in Africa. Using a retrospective chart review research method, the researchers aimed to describe the palliative care needs of people using a nurse-led palliative care service situated in a newly established, underserved, informal settlement in Tshwane, Gauteng, South Africa. A quantitative inductive content analysis method was used to analyse the data. The sample realised at 48 (nÂ =Â 48). The ages of patients ranged from 21 to 78 with the median age 47. Nearly half (45.9%) of the patients were functionally illiterate. The records reflected 85 different medical diagnoses and some patients suffered more than one illness. The most common diagnosis was HIV/AIDS (54.2%). Furthermore, records revealed 379 health problems, ranging from 1 to 17 per patient, with an average of 8.1. Most problems were physical symptoms (50.3%; nÂ =Â 195), while 38.8Â per cent (nÂ =Â 147) were psychosocial problems and 9.8Â per cent (nÂ =Â 37) were spiritual problems. The need for pain relief (89.6%; nÂ =Â 43) was the greatest, followed by the need for emotional support. Patients suffering from various medical diagnoses used the services of the palliative care clinic. Patientsâ€™ care needs revolved around relief from total pain. Therefore, nurses should become aware of the suffering of palliative patients living in resource-poor communities, and through meticulous assessment, identify their main care needs.