bluuebunny/crossref_metadata_2025 huggingface dataset:
A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann–Pick Disease Type C
Authors: Sanchez Kayla L. , Shin Samuel D. , Rajagopal Naren P. , White Jacob B. , Currais Antonio , Soriano-Castell David , Maher Pamela , Soriano Salvador
Published: August 2024

Niemann–Pick disease type C (NPC) is a rare and fatal neurological disorder caused by mutations in Npc1 or Npc2, with Npc1 accounting for 95% of cases. These mutations result in the functional loss of their respective proteins, causing cellular abnormalities characterized by disrupted lipid dysregulation, calcium dysfunction, elevated damage associated molecular patterns (DAMPs), and a pro-inflammatory environment. This cellular pathology ultimately triggers neurodegeneration, with the cerebellum being the earliest and most affected region. We have recently shown atypical activation of interferon signaling in the presymptomatic Npc1−/− mouse cerebellum and, to a lesser extent, in the cerebral cortex. In addition, we reported that the Amyloid Precursor Protein (APP) is an NPC disease modifier. Loss of APP function leads to widespread neurodegeneration in the NPC brain, including exacerbated interferon signaling in the cerebellum. To better understand the role of APP as a disease modifier throughout the NPC brain, here we carried out a transcriptomic analysis of the cerebral cortex and cerebellum from 3-week-old Npc1−/− mice as well as age-matched controls in the presence and absence of APP. We report differential effects of APP loss of function in the cerebral cortex and cerebellum, including cholesterol and tau dysregulation, in both brain regions. Our findings demonstrate a novel link between APP loss and early pathogenic mechanisms in NPC.
Geomechanics and Geology of Marine Terraces of the Crotone Basin, Calabria (Italy)
Authors: Campilongo Gloria , Ponte Maurizio , Muto Francesco , Critelli Salvatore , Catanzariti Filippo , Milone Davide
Published: August 2024

This study investigates the geomechanical behavior of five terrace orders in the Crotone Basin. The purpose is to understand the physical–mechanical parameters of these terraces to determine whether rock or soil mechanics principles should be applied for stability analysis. Samples were collected from each terrace following an extensive field survey. Laboratory analyses were conducted to measure pulse velocities, uniaxial unconfined compressive strength, and compressive strength with truncated conical platens. The findings revealed key physical–mechanical parameters of the rocks, which are crucial for stability assessments. The Crotone Basin, known for its mineral resources such as hydrocarbons and rock salts, has been studied geologically since before the 1950s, but there is a lack of geomechanical data in existing literature. Therefore, the results presented here are novel and provide a basis for future studies on the instability of rocky slopes composed of similar soft rock types. These results will aid in accurate geological–geotechnical model reconstructions. While the findings can be applied to similar cases, it is important to note that each analysis site, despite showing similar phenomena, is unique and requires individual investigation.
Occupational Injuries of Spanish Wildland Firefighters: A Descriptive Analysis
Authors: García-Heras Fabio , Rodríguez-Medina Juan , Castañeda Arkaitz , León-Guereño Patxi , Gutiérrez-Arroyo Jorge
Published: August 2024

The work of wildland firefighters, especially of the so-called ‘Brigadas de Refuerzo contra Incendios Forestales’, is characterised by high physical demands and extreme operating conditions. These professionals face long workdays (12 h), walking with heavy loads (~25 kg), being exposed to high temperatures (>30 °C), and handling specialised tools in high-risk environments. This study aimed to describe the prevalence of occupational injuries among members of the ‘Brigadas de Refuerzo contra Incendios Forestales’ and its relationship to variables such as age and work experience. A total of 217 wildland firefighters (18 female and 199 male) correctly answered a questionnaire developed on an ad hoc basis to meet the study’s objectives. A high prevalence of occupational injuries was observed among them (~76%). Age and work experience were shown to be significantly associated with injuries. Individuals over 35 years of age with more than 10 years’ experience had a higher probability of injury (OR = 2.14, CI = 1.12–4.06 and OR = 2.46, CI = 1.30–4.67, respectively). Injuries occurred mainly during physical training (~46%), followed by preventive work (~33%) and forest fires (~20%). The most common injuries were tendonitis and muscle pain (~44% and ~21% respectively), followed by sprains (~21%). The results underline the need for physical activity programmes adapted to help wildland firefighters, especially older and more experienced individuals. The identification of risk factors such as age and work experience can contribute to the prevention and management of occupational injuries among this group of highly specialised forestry workers. Specific preventative measures during training are required to mitigate the risk of injury among these crews, who play a crucial role in protecting the environment and public safety.
Eating Behaviors during Pregnancy: A Cross-Sectional Study
Authors: Al Hamimi Jawaher , Al Shidhani Asma , Al Mamari Maya , Al Wahaibi Ahmed , Al Awaidy Salah T.
Published: August 2024

Background: Eating disorders are complex illnesses with serious long-term consequences. They are linked to negative outcomes such as miscarriage, low birth weight, and other obstetric and postpartum difficulties. Our study in Muscat, Oman, examines the eating habits of pregnant women who consult primary care physicians. In this study, our aim is to identify key sociodemographic factors linked with eating disorders in Oman. Method: We used the Eating Disorder Examination Questionnaire to assess the potential for the presence of eating disorders. Chi-Square and Fisher’s Exact tests were used to analyze relationships between improper eating behavior and independent variables. Results: The study showed that 1.6% of participants had a potential diagnosis of an eating disorder, with the most common inappropriate behavior being binge eating at a prevalence of 18.8%. A pre-gestational low Body Mass Index (BMI) was associated with a higher prevalence of binge eating during pregnancy. Additionally, we found that pregnant women who were working were more prone to self-induced vomiting. High BMI before pregnancy was significantly associated with various inappropriate eating behaviors, such as restraint behavior (p = 0.000), shape concern (p = 0.000), weight concern (p = 0.040), eating (p = 0.045), laxative use (p = 0.020), and excessive exercise (p = 0.043). Conclusion: The study reveals a high prevalence of eating disorders in pregnancy. Less educated women exhibit higher laxative use, while working women show more instances of binge eating and self-induced vomiting. These findings emphasize the critical need to prioritize targeted interventions and support for vulnerable pregnant women.
Prey Switching and Natural Pest Control Potential of Carabid Communities over the Winter Wheat Cropping Season
Authors: Sacco--Martret de Préville Ambre , Staudacher Karin , Traugott Michael , Bohan David A. , Plantegenest Manuel , Canard Elsa
Published: August 2024

To date, evaluating the diets of natural enemies like carabids has largely been limited to spatially explicit and short-term sampling. This leaves a knowledge gap for the intra-annual dynamics of carabid diets, and the provision and timing of delivery of natural pest control services. Season-long pitfall trapping of adult carabids was conducted in conventional winter wheat fields, from November 2018 to June 2019, in five French departments. Diagnostic Multiplex PCR of carabid gut contents was used to determine the dynamics of carabid diets. The overall detection rate of target prey DNA was high across carabid individuals (80%) but varied with the prey group. The rate of detection was low for pests, at 8.1% for slugs and 9.6% for aphids. Detection of intraguild predation and predation on decomposers was higher, at 23.8% for spiders, 37.9% for earthworms and 64.6% for springtails. Prey switching was high at the carabid community level, with pest consumption and intraguild predation increasing through the cropping season as the availability of these prey increased in the environment, while the detection of decomposer DNA decreased. Variation in diet through the cropping season was characterized by: (i) complementary predation on slug and aphid pests; and (ii) temporal complementarity in the predominant carabid taxa feeding on each pest. We hypothesize that natural pest control services delivered by carabids are determined by complementary contributions to predation by the different carabid taxa over the season.
Unraveling the Boundaries, Overlaps, and Connections between Schizophrenia and Obsessive–Compulsive Disorder (OCD)
Authors: Pardossi Simone , Cuomo Alessandro , Fagiolini Andrea
Published: August 2024

Schizophrenia (SCZ) and obsessive–compulsive disorder (OCD) typically have distinct diagnostic criteria and treatment approaches. SCZ is characterized by delusions, hallucinations, disorganized speech, and cognitive impairments, while OCD involves persistent, intrusive thoughts (obsessions) and repetitive behaviors (compulsions). The co-occurrence of these disorders increases clinical complexity and poses significant challenges for diagnosis and treatment. Epidemiological studies indicate a significant overlap, with prevalence rates of comorbid OCD in SCZ patients ranging from 12% to 25%, which is higher than in the general population. Etiological hypotheses suggest shared genetic, neurobiological, and environmental factors, with genetic studies identifying common loci and pathways, such as glutamatergic and dopaminergic systems. Neuroimaging studies reveal both overlapping and distinct neural abnormalities, indicating shared and unique neurobiological substrates. Environmental factors, like early life stressors and urbanicity, also contribute to the comorbidity. The overlapping clinical features of both disorders complicate diagnosis. Treatment approaches include combining SSRIs with antipsychotics and cognitive behavioral therapy (CBT). The complexity of SCZ and OCD comorbidity underscores the need for a dimensional, spectrum-based perspective on psychiatric disorders, alongside traditional categorical approaches, to improve diagnosis and treatment outcomes.
Volumetric Analyses of Dysmorphic Maxillofacial Structures Using 3D Surface-Based Approaches: A Scoping Review
Authors: Cappella Annalisa , Gaffuri Francesca , Yang Josh , Tartaglia Francesco Carlo , Solazzo Riccardo , Inchingolo Francesco , Tartaglia Gianluca Martino , Sforza Chiarella
Published: August 2024

Background/Objectives: Three-dimensional (3D) analysis of maxillofacial structures in dysmorphic patients offers clinical advantages over 2D analysis due to its high accuracy and precision in measuring many morphological parameters. Currently, no reliable gold standard exists for calculating 3D volumetric measurements of maxillofacial structures when captured by 3D surface imaging techniques. The aim of this scoping review is to provide an overview of the scientific literature related to 3D surface imaging methods used for volumetric analysis of the dysmorphic maxillofacial structures of patients affected by CL/P or other syndromes and to provide an update on the existing protocols, methods, and, when available, reference data. Methods: A total of 17 papers selected according to strict inclusion and exclusion criteria were reviewed for the qualitative analysis out of more than 4500 articles published between 2002 and 2024 that were retrieved from the main electronic scientific databases according to the PRISMA-ScR guidelines. A qualitative synthesis of the protocols used for the selection of the anatomical areas of interest and details on the methods used for the calculation of their volume was completed. Results: The results suggest a great degree of heterogeneity between the reviewed studies in all the aspects analysed (patient population, anatomical structure, area selection, and volume calculation), which prevents any chance of direct comparison between the reported volumetric data. Conclusions: Our qualitative analysis revealed dissimilarities in the procedures specified in the studies, highlighting the need to develop uniform methods and protocols and the need for comparative studies to verify the validity of methods in order to achieve high levels of scientific evidence, homogeneity of volumetric data, and clinical consensus on the methods to use for 3D volumetric surface-based analysis.
Short-Term Atorvastatin Therapy in Healthy Individuals Results in Unaltered Plasma MMP Levels and Disrupted MMP-7 Correlation with Blood Lipids and Blood Count-Derived Inflammatory Markers
Authors: Mănescu Ion Bogdan , Mănescu Măriuca , Bărcuțean Laura Iulia , Demian Liliana , Dobreanu Minodora
Published: August 2024

Background: Matrix metalloproteinases (MMPs) play an important role in the pathophysiology of atherosclerosis. Reportedly, statins can decrease MMP activity in patients with atherosclerotic cardiovascular disease, but this effect has not been studied in healthy individuals. Methods: MMPs 2, 7, and 9 and several other parameters were measured before and after a four-week course of moderate-dose atorvastatin (20 mg/day) in 21 healthy individuals. Results: Atorvastatin treatment resulted in lower total cholesterol, LDL-cholesterol, non-HDL-cholesterol, and triglycerides (p < 0.001 for all), but higher levels of plasma enzymes AST, ALT, CK, and LDH (p < 0.05 for all). No effect of atorvastatin on plasma MMP median concentrations was recorded. Before treatment, moderate positive significant correlations were found between MMP-7 and age, blood lipids, and blood count-derived inflammatory markers. Pre-treatment MMP-7 was best predicted by the total cholesterol-to-HDL cholesterol ratio in a remnant cholesterol-weighted least squares regression model. After atorvastatin treatment, MMP-7 no longer correlated with these markers. Conclusions: While the effect of statins on plasma MMPs in atherosclerosis is controversial, short-term moderate-dose atorvastatin treatment does not seem to affect levels of MMPs 2, 7, and 9 in healthy individuals. However, an intriguing correlation between MMP-7 and atherosclerosis-related blood lipids and neutrophil-associated inflammatory biomarkers seems to be disrupted by atorvastatin independently of hsCRP, possibly via pleiotropic effects.
Impact of Laparoscopic Sleeve Gastrectomy on Fatigue in Obese Patients
Authors: Tasdoven Ilhan , Balbaloglu Hakan
Published: August 2024

Background: Fatigue with obesity negatively affects the motivation to lose weight and causes failure of treatment. So, obesity and fatigue are two related entities that worsen each other in a vicious circle. This study aimed to examine the changes in fatigue levels in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). Methods: Preoperative and postoperative BMI, fat percentage, and obesity degree were determined based on Tanita test results, and the rates of change were calculated. The Fatigue Assessment Scale (FAS) was used to assess the impact of obesity on mental and physical fatigue. Results: Six months after LSG, there was a 29.7% decrease in Body Mass Index (BMI) across all patients (45.0 to 31.4, p < 0.001). Significant reductions in the percentage of body fat, obesity grade, and HgA1C were observed in both women and men and overall (p < 0.001 for all comparisons). Scores on the Fatigue Assessment Scale (FAS) for total, mental, and physical scales decreased significantly for women, men, and all participants (p < 0.001 for all comparisons). There was a weak but significant positive correlation between the percentage change in FAS total and FAS physical scale scores and the change in BMI% (p = 0.015 and 0.004; r = 0.089, 0.106, respectively). Change in obesity grade and FAS physical subscale scores negatively correlated (p = 0.029, r = 0.080). Conclusions: LSG not only leads to significant weight reduction but also improves fatigue levels in patients with obesity.
Oral Semaglutide in Type 2 Diabetes: Clinical–Metabolic Outcomes and Quality of Life in Real-World Practice
Authors: Pantanetti Paola , Ronconi Vanessa , Sguanci Marco , Palomares Sara Morales , Mancin Stefano , Tartaglia Francesco Carlo , Cangelosi Giovanni , Petrelli Fabio
Published: August 2024

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a novel class of incretin mimetics for treating type 2 diabetes (T2D). This study evaluated the impact of semaglutide, the first oral GLP-1RA, on glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body composition and anthropometric parameters. Additionally, the effects on cardiovascular risk factors and quality of life (QoL) in T2D patients were assessed. Methods: A prospective observational study with a six-month follow-up was conducted. Clinical parameters, including HbA1c, FPG, anthropometric measurements, blood pressure, cardiovascular risk factors, Diabetes Treatment Satisfaction Questionnaire (DTSQ) responses, and Short Form (36) Health Survey (SF-36) responses, were collected at baseline (T0) and at six months (T1). Results: Sixty-one subjects were enrolled, with there being an average T2D duration of 4.67 ± 3.93 years. Significant decreases were observed in HbA1c (µ = −1.24; SD = 1.33; p < 0.05), FPG (µ = −31.01 mg/dL; SD = 41.71; p < 0.05), body composition and anthropometric parameters (p < 0.05), and cardiovascular risk factors (p < 0.05), with an increase in DTSQ scores (p < 0.05). Conclusions: The administration of 14 mg/day oral semaglutide improved several clinical parameters after six months of treatment. These findings suggest semaglutide is effective in improving glycemic control, weight management, and some cardiovascular risk factors in T2D patients.
Impact of Hysteroscopic Polypectomy on IVF Outcomes in Women with Unexplained Infertility
Authors: Triantafyllidou Olga , Korompokis Ilias , Chasiakou Stamatia , Bakas Panagiotis , Kalampokas Theodoros , Simopoulou Mara , Tzanakaki Despoina , Kalampokas Emmanouil , Panagodimou Evangelia , Xepapadaki Maria , Christopoulos Panagiotis , Valsamakis Georgios , Vlahos Nikolaos F
Published: August 2024

Objective: To assess the effect of hysteroscopic polypectomy on the in vitro fertilization (IVF) results in infertile women with at least one prior negative IVF outcome. Methods: This retrospective cohort study included women who had attended the “2nd Department of Obstetrics and Gynecology of the National and Kapodistrian University of Athens” and “Iaso” Maternity Hospital from October 2019 to January 2023 for infertility treatment. The medical records of 345 women aged 18–45 years old without abnormal findings in hysterosalpingography (HSG) and with at least one previous failed IVF procedure were analyzed. The male factor was excluded, as well as a prior hysteroscopic removal of polyps. In 67 women, polyps were suspected during initial two-dimensional ultrasound (2D-US) examination. The final sample of the study comprised 40 patients, in which endometrial polyps were removed by hysteroscopy with the use of resectoscope. All patients underwent ovarian stimulation and IVF in the consecutive cycle using a short GnRh antagonist protocol. Main Results: After hysteroscopic polypectomy, 29 (72.5%) out of 40 patients had a positive pregnancy result: 26 (65%) clinical and 3 (7.5%) biochemical pregnancies were documented. There was a statistically significant difference between the number of clinical pregnancies before and after polypectomy (p < 0.001), as well as between the total number of pregnancies (p < 0.001). Secondary Results: Women with positive outcome were significantly younger and had significantly lower FSH levels (p < 0.007). They also had significantly higher AMH (p < 0.009) and peak estradiol levels (p < 0.013) and yielded more M II oocytes (p < 0.009) and embryos (p < 0.002). Conclusions: Hysteroscopic polypectomy in women with a suspected endometrial polyp using 2D ultrasound and a history of prior failed IVF attempt improves IVF outcomes in terms of the clinical and total number of pregnancies.
A Novel Open Set Adaptation Network for Marine Machinery Fault Diagnosis
Authors: Su Yulong , Guo Yu , Zhang Jundong , Shi Jun
Published: August 2024

Domain adaptation techniques have effectively tackled fault diagnosis under varying operational conditions. Many existing studies presume that machine health states remain consistent between training and testing data. However, in real-world scenarios, fault modes during testing are often unpredictable, introducing unknown faults that challenge the effectiveness of domain adaptation-based fault diagnosis methods. To address these challenges, this paper proposes a Deep Open Set Domain Adaptation Network (DODAN). Firstly, a feature extraction module based on multi-scale depthwise separable convolutions is constructed for discriminative feature extraction. To improve the model’s adaptability, an adversarial training strategy is implemented to learn generalized features that are resilient to unknown domain shifts. Additionally, an outlier detection module is employed to determine the optimal decision boundaries for each class representation space, enabling the classification of known fault modes and the identification of unknown ones. Extensive diagnostic experiments on two marine machinery datasets validate the effectiveness of the proposed method. Furthermore, ablation studies verify the efficacy of the proposed modules and strategies, highlighting significant potential for practical applications.
Transcriptome Analysis Reveals the Regulatory Mechanism of Lipid Metabolism and Oxidative Stress in Litopenaeus vannamei under Low-Salinity Stress
Authors: Cao Siyao , Li Yundong , Jiang Song , Yang Qibin , Huang Jianhua , Yang Lishi , Shi Jianzhi , Jiang Shigui , Wen Guoliang , Zhou Falin
Published: August 2024

Salinity is a crucial environmental factor influencing the survival, growth, development, and reproduction of aquatic animals. However, the underlying molecular mechanisms of the shrimp’s response to salinity stress are not yet fully understood. Therefore, we used the Illumina NovaSeq 6000 platform to perform transcriptome sequencing of the hepatopancreas of Litopenaeus vannamei under high-salinity (30 PSU), medium-salinity (10 PSU), and low-salinity (0.5 PSU) conditions. We obtained 63.23 Gb of high-quality data and identified 3589 differentially expressed genes (DEGs), including 1638 upregulated and 1951 downregulated genes. Notably, a comparison between the control group (30 PSU) and the low-salinity group (0.5 PSU) revealed that the BBOX1 and CHE1 genes were significantly upregulated, while the ACOX1, MPV, CYP2L1, GCH, MVK, TREt1, and XDH genes were significantly downregulated. These genes are primarily involved in key metabolic pathways, such as fatty acid oxidation, cholesterol metabolism, and hormone synthesis and metabolism. The key genes involved in fatty acid β-oxidation, such as ACOX1, ACAD, HADH, HSD17B4, PECR, CROT, PIPOX, and CG5009, all showed a downward trend, suggesting that L. vannamei may respond to salt stress by regulating fatty acid oxidative metabolism, optimizing energy utilization, and maintaining cell homeostasis under low-salinity conditions. Functional annotation of gene ontology (GO) and KEGG pathway enrichment analysis highlighted the roles of these significant DEGs in the adaptation of L. vannamei to environments of varying salinity, underscoring the importance of metabolic pathways in their adaptive physiological responses. This study provides a crucial molecular biological basis for understanding the molecular mechanisms and physiological protection strategies of L. vannamei under salinity stress.
Hydrodynamic Analysis and Drag-Reduction Design of an Unmanned Underwater Vehicle Based on Computational Fluid Dynamics
Authors: Li Xuecheng , Zhang Desheng , Zhao Ming , Wang Xin , Shen Yu
Published: August 2024

In order to establish a proper geometry of an Unmanned Underwater Vehicle (UUV) for stable motion control and energy usage reduction, this paper analyzes the hydrodynamic performance of a complex shape underwater vehicle and develops a systematic Computational Fluid Dynamics (CFD) simulation method to solve the hydrodynamic parameters of the system. Based on the simulation method and their results, the streamlines and pressure distributions of the water flow around the underwater vehicle are analyzed, and the geometric model design is improved based on the drag characteristics. Also, a comparison scheme is designed to evaluate the vehicle model before and after the geometry improvement. Simulation result shows that the design schemes brings 18% drag reductions in surge direction and 32% in heave direction. Moreover, by establishing the physical and mathematical models of the UUV on a physical simulation platform, a complete model of the underwater vehicle is constructed, laying the foundation for further simulations and experiments.
Monitoring the Soil Copper of Urban Land with Visible and Near-Infrared Spectroscopy: Comparing Spectral, Compositional, and Spatial Similarities
Authors: Liu Yi , Shi Tiezhu , Chen Yiyun , Lan Zeying , Guo Kai , Zhuang Dachang , Yang Chao , Zhang Wenyi
Published: August 2024

Heavy metal contamination in urban land has become a serious environmental problem in large cities. Visible and near-infrared spectroscopy (vis-NIR) has emerged as a promising method for monitoring copper (Cu), which is one of the heavy metals. When using vis-NIR spectroscopy, it is crucial to consider sample similarity. However, there is limited research on studying sample similarities and determining their relative importance. In this study, we compared three types of similarities: spectral, compositional, and spatial similarities. We collected 250 topsoil samples (0–20 cm) from Shenzhen City in southwest China and analyzed their vis-NIR spectroscopy data (350–2500 nm). For each type of similarity, we divided the samples into five groups and constructed Cu measurement models. The results showed that compositional similarity exhibited the best performance (Rp2 = 0.92, RPD = 3.57) and significantly outperformed the other two types of similarity. Spatial similarity (Rp2 = 0.73, RPD = 1.88) performed slightly better than spectral similarity (Rp2 = 0.71, RPD = 1.85). Therefore, we concluded that the ranking of the Cu measurement model’s performance was as follows: compositional similarity > spatial similarity > spectral similarity. Furthermore, it is challenging to maintain high levels of similarity across all three aspects simultaneously.
Canine Distemper Virus: Origins, Mutations, Diagnosis, and Epidemiology in Mexico
Authors: Rivera-Martínez Alejandra , Rodríguez-Alarcón Carlos A. , Adame-Gallegos Jaime R. , Laredo-Tiscareño S. Viridiana , de Luna-Santillana Erick de Jesús , Hernández-Triana Luis M. , Garza-Hernández Javier A.
Published: August 2024

This review provides an overview of the canine distemper virus (CDV), a highly infectious pathogen causing severe disease in domestic dogs and wildlife. It shares genetic similarities with the human measles virus (HMV) in humans and the rinderpest virus (RPV) in cattle. The origin of CDV likely involves a mutation from human measles strains, possibly in the New World, with subsequent transmission to dogs. CDV has been globally observed, with an increasing incidence in various animal populations. Genomic mutations, especially in the H protein, contribute to its ability to infect different hosts. Diagnosis by molecular techniques like RT-qPCR offers rapid and sensitive detection when compared with serological tests. Genomic sequencing is vital for understanding CDV evolution and designing effective control strategies. Overall, CDV poses a significant threat, and genomic sequencing enhances our ability to manage and prevent its spread. Here, the epidemiology of CDV principally in Mexico is reviewed.
Investigations on the Effects of Bonding and Forming Conditions on the Deformation Behavior of Copper–Steel Bimetallic Rods during the Cold Drawing Processes
Authors: Hwang Yeong-Maw , Tsui Hiu Shan Rachel , Lu Cheng-Yu
Published: August 2024

Metal composite parts are widely used in different industries owing to their significant improvement in material properties, such as mechanical strength, electrical conductivity, and corrosion resistivity, compared to traditional single metals. Such composite parts can be manufactured and processed in different ways to achieve the desired geometry and quality. Among various metal forming techniques, drawing is the most commonly used process to produce long composite wires or rods from raw single materials. During the drawing process of composite wires or rods, not only does the core radius ratio change, but the core or sleeve layer may also undergo necking or fracture due to excessive tensile stresses in the softer layer. In this paper, bimetallic rods with AISI-1006 low-carbon steel cores and C10100 oxygen-free electronic copper sleeves are modeled using the finite element software DEFORM. The simulation models are verified by drawing experiments. The effects of initial bonding conditions, the initial core ratio, reduction ratio, semi-die angle, drawing speed, and friction on the plastic deformation behavior of the bimetallic rods are investigated. The results indicate that the initial bonding conditions have a great impact on the deformation behavior of the billets in terms of strain distribution, material flow, residual stress, and the final core ratio. The permissible forming parameters for obtaining a sound product are investigated as well. With the aid of these analyses, the drawing process and the quality of the products can be controlled steadily.
Nanocomposites of Natural Rubber Containing Montmorillonite Modified by Poly(2-oxazolines)
Authors: Boháč Peter , Nógellová Zuzana , Šlouf Miroslav , Kronek Juraj , Jankovič Ľuboš , Peidayesh Hamed , Madejová Jana , Chodák Ivan
Published: August 2024

Nanocomposites with a natural rubber (NR) matrix containing organomodified montmorillonite (MMT) as a precursor of nanoparticles were prepared using two different polyoxazolines as surface modifiers of the MMT. The materials were characterized by X-ray diffraction, transmission electronic microscopy and ultimate mechanical properties, and parameters obtained by DMTA method (storage and loss moduli and loss tangent) were determined. It was found that the effect of nanofillers presence has a significant effect on tensile strength as well as elongation at break, which are higher for materials with higher viscosity due to the presence of carbon blacks compared to the composites without carbon blacks. From the two modifiers, poly(2-ethyl-2-oxazoline) was identified as a prospective modifier for surface modification of MMT used as the possible additive for tyre treads exhibiting optimal balance between fuel consumption and safety of driving concerning breaking action and lateral breakaway.
Enhancing Energy Storage Performance of 0.85Bi0.5Na0.5TiO3-0.15LaFeO3 Lead-Free Ferroelectric Ceramics via Buried Sintering
Authors: Zhang Yixiao , Jia Yuchen , Yang Jian , Feng Zixuan , Sun Shuohan , Zhu Xiaolong , Wang Haotian , Yan Shiguang , Zheng Ming
Published: August 2024

Bismuth sodium titanate (Bi0.5Na0.5TiO3, BNT) ceramics are expected to replace traditional lead-based materials because of their excellent ferroelectric and piezoelectric characteristics, and they are widely used in the industrial, military, and medical fields. However, BNT ceramics have a low breakdown field strength, which leads to unsatisfactory energy storage performance. In this work, 0.85Bi0.5Na0.5TiO3-0.15LaFeO3 ceramics are prepared by the traditional high-temperature solid-phase reaction method, and their energy storage performance is greatly enhanced by improving the process of buried sintering. The results show that the buried sintering method can inhibit the formation of oxygen vacancy, reduce the volatilization of Bi2O3, and greatly improve the breakdown field strength of the ceramics so that the energy storage performance can be significantly enhanced. The breakdown field strength increases from 210 kV/cm to 310 kV/cm, and the energy storage density increases from 1.759 J/cm3 to 4.923 J/cm3. In addition, the energy storage density and energy storage efficiency of these ceramics have good frequency stability and temperature stability. In this study, the excellent energy storage performance of the ceramics prepared by the buried sintering method provides an effective idea for the design of lead-free ferroelectric ceramics with high energy storage performance and greatly expands its application field.
Enhancing High-Alloy Steel Cutting with Abrasive Water Injection Jet (AWIJ) Technology: An Approach Using the Response Surface Methodology (RSM)
Authors: Perec Andrzej , Kawecka Elzbieta , Pude Frank
Published: August 2024

The common machining technologies for difficult-to-machine materials do not remarkably ensure acceptable efficiency and precision in bulk materials cutting. High-energy abrasive water injection jet (AWIJ) treatment can cut diverse materials, even multi-layer composites characterized by divergent properties, accurately cutting complex profiles and carrying them out in special circumstances, such as underwater locations or explosion hazard areas. This work reports research on the AWIJ machining quality performance of X22CrMoV12-1 high-alloy steel. The response surface method (RSM) was utilized in modeling. The most influencing process control parameters on cut kerf surface roughness—abrasive flow rate, pressure, and traverse speed—were tested. The result is a mathematical model of the process in the form of a three-variable polynomial. The key control parameter affecting the cut slot roughness turned out to be the traverse speed. In contrast, pressure has a less significant effect, and the abrasive mass flow rate has the slightest impact on the cut slot roughness. Under the optimal conditions determined as a result of the tests, the roughness of the intersection surface Sq does not exceed 2.3 μm. Based on the ANOVA, we confirmed that the model fits over 96% appropriately with the research outcomes. This method reduces the computations and sharply determines the optimum set of control parameters.
Misalignment Assembly Effect on the Impact Mechanical Response of Tandem Nomex Honeycomb-Core Sandwich Structures
Authors: Yin Yufan , Zhang Xiaojing
Published: August 2024

To optimize the assembly methods of honeycomb structures and enhance their design flexibility, this study investigated the impact mechanical responses of tandem honeycomb-core sandwich structures with varying misalignment assembly lengths. Impact tests were conducted across different energy levels on single-layer and tandem honeycomb-core sandwiches to observe their impact processes and failure behaviors. Our findings indicate that tandem honeycomb cores significantly enhance the impact resistance compared with single-layer configurations, even though a misaligned assembly can deteriorate this property. A finite element model was developed and validated experimentally; the model showed good agreement with the experiments, thereby allowing the simulation and evaluation of the impact responses. Herein, we reveal that specific misalignment lengths can either increase or decrease the impact resistance, providing insights into improving the resilience of tandem honeycomb-core structures. Our results not only contribute to enhancing the impact resistance of honeycomb-core sandwich structures but also offer a valuable basis for their practical applications in engineering.
Perovskite versus Standard Photodetectors
Authors: Rogalski Antoni , Hu Weida , Wang Fang , Wang Yang , Martyniuk Piotr
Published: August 2024

Perovskites have been largely implemented into optoelectronics as they provide several advantages such as long carrier diffusion length, high absorption coefficient, high carrier mobility, shallow defect levels and finally, high crystal quality. The brisk technological development of perovskite devices is connected to their relative simplicity, high-efficiency processing and low production cost. Significant improvement has been made in the detection performance and the photodetectors’ design, especially operating in the visible (VIS) and near-infrared (NIR) regions. This paper attempts to determine the importance of those devices in the broad group of standard VIS and NIR detectors. The paper evaluates the most important parameters of perovskite detectors, including current responsivity (R), detectivity (D*) and response time (τ), compared to the standard photodiodes (PDs) available on the commercial market. The conclusions presented in this work are based on an analysis of the reported data in the vast pieces of literature. A large discrepancy is observed in the demonstrated R and D*, which may be due to two reasons: immature device technology and erroneous D* estimates. The published performance at room temperature is even higher than that reported for typical detectors. The utmost D* for perovskite detectors is three to four orders of magnitude higher than commercially available VIS PDs. Some papers report a D* close to the physical limit defined by signal fluctuations and background radiation. However, it is likely that this performance is overestimated. Finally, the paper concludes with an attempt to determine the progress of perovskite optoelectronic devices in the future.
In-Situ Sulfuration of CoAl Metal–Organic Framework for Enhanced Supercapacitor Properties
Authors: Liao Mengchen , Zhang Kai , Luo Chaowei , Wu Guozhong , Zeng Hongyan
Published: August 2024

Designing efficient electrode materials is necessary for supercapacitors but remains highly challenging. Herein, cobalt sulfide with crystalline/amorphous heterophase (denoted as Co(Al)S) derived from an Al metal–organic framework was constructed by ion exchange/acid etching and subsequent sulfidation strategy. It was found that rational sulfidation by adjusting the sulfur source concentration to a suitable level was favorable to form a 3D nanosheet-interconnected network architecture with a large specific surface area, which promoted ion/electron transport and charge separation. Benefiting from the features of the unique network structure and heterophase accompanied by aluminum, nitrogen and carbon coordinated in amorphous phase, the optimal Co(Al)S(10) exhibited a high specific capacity (1791.8 C g−1 at 1 A g−1), an outstanding rate capability and an excellent cycling stability. Furthermore, the as-assembled Co(Al)S//AC device afforded an energy density of 72.3 Wh kg−1 at a power density of 750 W kg−1, verifying that the Co(Al)S was a promising material for energy storage devices. The developed scheme is expected to promote the application of MOF-derived electrode materials in electrochemical energy storage and conversion fields.
The Influence of Silica Fly Ash and Wood Bottom Ash on Cement Hydration and Durability of Concrete
Authors: Malaiškienė Jurgita , Vaičienė Marija
Published: August 2024

This research addresses a notable gap in understanding the synergistic effects of high carbon wood bottom ash (BA) and silica fly ash (FA) on cement hydration and concrete durability by using them as a supplementary material to reduce the amount of cement in concrete and CO2 emissions during cement production. This study analyses the synergistic effect of FA and BA on cement hydration through X-ray diffraction (XRD), thermal analysis (TG, DTG), scanning electron microscopy (SEM), density, ultrasonic pulse velocity (UPV), compressive strength, and temperature monitoring tests. In addition, it evaluates concrete properties, including compressive strength, UPV, density, water absorption kinetics, porosity parameters, predicted resistance to freezing and thawing cycles, and results of freeze–thawing resistance. The concrete raw materials were supplemented with varying percentages of BA and FA, replacing both cement and fine aggregate at levels of 0%, 2.5%, 5%, 10% and 15%. The results indicate that a 15% substitution of BA and FA delays cement hydration by approximately 5 h and results in only a 6% reduction in compressive strength, with the hardened cement paste showing a strength similar to a 15% replacement with FA. Concrete mixtures with 2.5% BA and 2.5% FA maintained the same maximum hydration temperature and duration as the reference mix. Furthermore, the combined use of both ashes provided adequate resistance to freeze–thaw cycles, with only a 4.7% reduction in compressive strength after 150 cycles. Other properties, such as density, UPV and water absorption, exhibited minimal changes with partial cement replacement by both ashes. This study highlights the potential benefits of using BA and FA together, offering a sustainable alternative that maintains concrete performance while using waste materials.
Diverse but Relevant Recommendations with Continuous Ant Colony Optimization
Authors: Yılmazer Hakan , Özel Selma Ayşe
Published: August 2024

This paper introduces a novel method called AcoRec, which employs an enhanced version of Continuous Ant Colony Optimization for hyper-parameter adjustment and integrates a non-deterministic model to generate diverse recommendation lists. AcoRec is designed for cold-start users and long-tail item recommendations by leveraging implicit data from collaborative filtering techniques. Continuous Ant Colony Optimization is revisited with the convenience and flexibility of deep learning solid methods and extended within the AcoRec model. The approach computes stochastic variations of item probability values based on the initial predictions derived from a selected item-similarity model. The structure of the AcoRec model enables efficient handling of high-dimensional data while maintaining an effective balance between diversity and high recall, leading to recommendation lists that are both varied and highly relevant to user tastes. Our results demonstrate that AcoRec outperforms existing state-of-the-art methods, including two random-walk models, a graph-based approach, a well-known vanilla autoencoder model, an ACO-based model, and baseline models with related similarity measures, across various evaluation scenarios. These evaluations employ well-known metrics to assess the quality of top-N recommendation lists, using popular datasets including MovieLens, Pinterest, and Netflix.
Advanced Neural Classifier-Based Effective Human Assistance Robots Using Comparable Interactive Input Assessment Technique
Authors: Albekairi Mohammed , Kaaniche Khaled , Abbas Ghulam , Mercorelli Paolo , Alanazi Meshari D. , Almadhor Ahmad
Published: August 2024

The role of robotic systems in human assistance is inevitable with the bots that assist with interactive and voice commands. For cooperative and precise assistance, the understandability of these bots needs better input analysis. This article introduces a Comparable Input Assessment Technique (CIAT) to improve the bot system’s understandability. This research introduces a novel approach for HRI that uses optimized algorithms for input detection, analysis, and response generation in conjunction with advanced neural classifiers. This approach employs deep learning models to enhance the accuracy of input identification and processing efficiency, in contrast to previous approaches that often depended on conventional detection techniques and basic analytical methods. Regardless of the input type, this technique defines cooperative control for assistance from previous histories. The inputs are cooperatively validated for the instruction responses for human assistance through defined classifications. For this purpose, a neural classifier is used; the maximum possibilities for assistance using self-detected instructions are recommended for the user. The neural classifier is divided into two categories according to its maximum comparable limits: precise instruction and least assessment inputs. For this purpose, the robot system is trained using previous histories and new assistance activities. The learning process performs comparable validations between detected and unrecognizable inputs with a classification that reduces understandability errors. Therefore, the proposed technique was found to reduce response time by 6.81%, improve input detection by 8.73%, and provide assistance by 12.23% under varying inputs.
Cauchy Problem for Stochastic Nonlinear Schrödinger Equation with Nonlinear Energy-Critical Damping
Authors: Miao Lijun , Qiu Linlin
Published: August 2024

We consider the Cauchy problem for the stochastic nonlinear Schrödinger equation augmented by nonlinear energy-critical damping term arising in nonlinear optics and quantum field theory. Through examining the behavior of the momentum and energy functionals, we almost surely prove the existence and uniqueness of global solutions with continuous H1(Rd) valued paths. The results cover either defocusing nonlinearity in the full energy critical and subcritical range of exponents or focusing nonlinearity in the full subcritical range, as in the deterministic case.
Transverse Compression of a Thin Inhomogeneous Elastic Layer
Authors: Alzaidi Ahmed S. M. , Kaplunov Julius , Zupančič Barbara , Nikonov Anatolij
Published: August 2024

A 3D problem in linear elasticity is considered for a thin inhomogeneous layer subject to transverse compression. For the first time, the effect of arbitrary vertical inhomogeneity is elucidated. Two sets of boundary conditions along the faces of the layer are adapted for modelling transverse compression. Robust asymptotic formulae involving repeated integrals across the thickness are derived for displacements and stresses. As an illustration, numerical results are presented for the elastic moduli having a transverse parabolic variation. The obtained results have a potential to be implemented in modern technology, including manufacturing and design of functionally graded materials.
Absorptive Capacity of Gingival Retraction Cords in Hemostatic Solutions: An In Vitro Study
Authors: Makakova Desislava R. , Zagorchev Plamen , Dimitrova Mariya , Georgieva Yoanna , Tilov Boris
Published: August 2024

Background and Objectives: Gingival retraction is a critical pre-impression procedure in fixed prosthodontics, crucial for exposing tooth margins and ensuring accurate impressions for restorations like crowns and bridges. This study aimed to evaluate the absorptive capacity of different gingival retraction cords. Materials and Methods: Ninety samples each of Ultrapak (Ultradent, South Jordan, UT, USA) #00, braided cord, coreless thread, and monofilament thread (totaling 270 samples) were immersed in 0.9% NaCl, 10% aluminum chloride, and 12.7% ferrous sulfate solutions for 120, 300, and 1200 s. The liquid absorption capacity was measured using a gravimetric method, and the data were analyzed using an F-test, setting the significance threshold at p < 0.05. Results: The results revealed statistically significant differences in absorption, particularly for aluminum chloride and ferric sulfate (p < 0.001). Ultrapak demonstrated the highest absorption, followed by the coreless cotton thread, while the monofilament thread absorbed the least, especially at 1200 s. Conclusions: These findings indicate that Ultrapak’s superior absorption could enhance moisture control during procedures, highlighting the importance of selecting an appropriate retraction cord for optimal clinical outcomes. Further research is needed to confirm these findings in a clinical setting.