bluuebunny/crossref_metadata_2025 huggingface dataset:
Electroencephalogram is activated by addition of pentobarbital in the isolated perfused rat head
Authors: Tagawa A , Mokuda O , Sakamoto Y , Shimizu N
Published: August 2023

To evaluate the direct effects of a barbiturate on cerebral functions without its influence on brain perfusion pressure, circulatory hormones and metabolites, the electroencephalogram (EEG) was studied in the isolated rat head. Male Wistar rats were anesthetized, and EEG electrodes were inserted into the cranium. A Krebs-Ringer bicarbonate buffer solution containing heparinized rat whole blood, 20 mmol/l glucose, 200 mmol/l mannitol and 0.1 mg/ml dexamethasone was used for the perfusate. The bilateral common carotid arteries were cannulated, pumped at a rate of 6 ml/min and the head was isolated. The venous effluent was reoxygenated and recirculated into the brain. Twenty-five min after isolation of the heads pentobarbital was added to the perfusate at concentrations of 0.1, 0.5 and 2.5 mg/ml. EEG was recorded before and during perfusion. EEG activity could be recorded for more than 25 min after the beginning of perfusion. EEG activity gradually declined from 42±5 μV before perfusion (in vivo) to 4±1 μV at 25 min after the beginning of perfusion. Then, 3 min after the addition of pentobarbital, the EEG activity became significantly higher in the high dose groups; 12±3 μV in the 0.5 mg/ml group (p<0.05) and 12±1 μV in 2.5 mg/ml group (p<0.05) compared with the group without pentobarbital (2±2 μV). The present study suggests that a barbiturate has mitigating effects on the brain damage induced by the in vitro brain perfusion.
Preconditioning by hypoventilation increases ventricular arrhythmia threshold in Wistar rats
Authors: Švorc P , Bračoková I
Published: August 2023

Hypoventilation, as one of ventilatory disorders, decreases the electrical stability of the heart similarly as ischemia. If preconditioning by short cycles of ischemia has a cardioprotective effect against harmful influences of a prolonged ischemic period, then preconditioning by hypoventilation (HPC) can also have a similar effect. Anesthetized rats (ketamine 100 mg/kg + xylasine 15 mg/kg i.m., open chest experiments) were subjected to 20 min of hypoventilation followed by 20 min of reoxygenation (control group). The preconditioning (PC) was induced by one (1PC), two (2PC) or three (3PC) cycles of 5-min hypoventilation followed by 5-min reoxygenation. The electrical stability of the heart was measured by a ventricular arrhythmia threshold (VAT) tested by electrical stimulation of the right ventricle. Twenty-minute hypoventilation significantly decreased the VAT in the control and 1PC groups (p<0.05) and non-significantly in 2PC vs. the initial values. Reoxygenation reversed the VAT values to the initial level only in the control group. In 3PC, the VAT was increased from 2.32±0.69 mA to 4.251.31 mA. during hypoventilation (p<0.001) and to 4.37±1.99 mA during reoxygenation (p<0.001). It is concluded that cardioprotection against the hypoventilation/ reoxygenation-induced decrease of VAT proved to be effective only after three cycles of HPC.
Dehydroepiandrosterone – does the fountain of youth dry out?
Authors: Celec P , Stárka L
Published: August 2023

Dehydroepiandrosterone (DHEA) and its sulphate-bound form (DHEAS) are important steroids mainly of adrenal origin. Their physiological and pathophysiological functions are not yet fully identified, although a number of various possible features have been hypothesized. Most popular is the description of the "hormone of youth" as the long-term dynamics of DHEA levels are characterized by a sharp age-related decline in the late adulthood and later. Low levels of DHEA are, however, associated not only with the ageing process but also with diabetes mellitus, cardiovascular diseases and some neurological or immunological entities. In the past decade, a number of brief studies have concentrated on these relationships and also on the role of exogenous DHEA in health, disease and human well-being. This article tries to summarize some of the most important facts achieved recently.
IMPLEMENTATION OF PEDAGOGIC COMPETENCE THROUGH HUMANIST LEARNING PERSPECTIVE OF KI HADJAR DEWANTARA
Authors: Alghifari Gilang Arya , Ibrahim Fahmi , Parhan Muhamad
Published: August 2023

Education aims to construct students to become independent human beings physically and spiritually. To make this happen, educators must have pedagogic competence, which is necessary to support them as professional educators. The pedagogic concept is inseparable from a well-known figure in the world of education, namely Ki Hadjar Dewantara, who gave birth to the concepts of Momong, Among, and Ngemong, based on the concept of humanist education that shows the cultural characteristics of the Indonesian nation. The research method used is qualitative with a Case Study approach, which aims to find out the humanist concept of increasing teacher understanding. The research results indicate that to understand and protect the needs of students, it is necessary to understand pedagogical competency standards to become professional educators, and educators need to be involved in self-development, and collaboration in achieving humanist learning that includes students’ understanding, class management skills, and the ability to provide constructive feedback by determining one of which that refers to the educational concept of Ki Hadjar Dewantara.
IMPROVING THE FIFTH-GRADE ELEMENTARY STUDENTS’ LEARNING OUTCOMES IN INTEGRATED THEMATIC LEARNING ON THEME 6 USING TIME TOKEN MODEL
Authors: Melisandy Yolla , Lena Mai Sri
Published: August 2023

This paper is based on research about learning in which the students still obtain learning from the teachers only and the students did not contribute during the learning process mostly. It is because the teacher did not implement innovative, creative, and diverse models. The research aims to describe how Integrated Thematic learning assisted by Time Token model in Class V at SDN 16 Enam Lingkung in Padang Pariaman can improve students’ learning outcomes. The research approach is Classroom Action Research. The research subjects involved 18 teachers and students in class V. Data collection was carried out through observations, documents, tests, and non-tests. The research was conducted in two phases, Cycle I and II. In Cycle I, according to the lesson plan's findings, the average percentage was 83.33% (excellent), conversely, in Cycle II, the average percentage was 94.44%. (excellent). In Cycle I, according to the teacher, the average percentage was 82.81% (good), conversely, in Cycle II, the average percentage was 93.75%. (excellent). Students' average learning outcomes in Cycle I were 75.9% and the student’s average learning outcomes in Cycle II were 89.13%. Thus, the Time Token technique in integrated thematic learning indicates students' learning outcomes produce an improvement.
PROFESSIONAL DEVELOPMENT ACTIVITY AND TEACHERS’ LEARNING EXPERIENCES IN THE MIDST OF THE COVID-19 PANDEMIC
Authors: Rahmadhina Felicia Fitria , White Ani Pujiastuti
Published: August 2023

This paper descriptively discusses the type of professional development activities attended by teachers during the Covid-19 pandemic and what learning and experience they obtained from the activities. The data are gathered qualitatively from open-ended questionnaires. The participants involved elementary school teachers from several regions in Indonesia. The participants (N=56) described various types of professional development activities they attended during the Covid-19 pandemic, which consisted of webinars, training, seminars, workshops, teachers gathering and networking, online courses, and supervision. The teachers also state that they obtained benefits from the professional development activities they attended. It is recommended that further researchers can study various aspects of professional development activities for teachers in Indonesia, especially in the contexts of elementary school and pre-service teachers.
THE EFFECT OF TRI HITA KARANA-BASED PROBLEM-BASED LEARNING MODEL ON ECOLOGICAL ATTITUDES AND LEARNING OUTCOMES
Authors: Suarni Kade Dwi
Published: August 2023

This paper discusses the effect of Tri Hita Karana-based problem-based learning model on ecological attitudes and natural science (IPA) learning outcomes. The research type is a quasi-experimental with non-equivalent post-test-only control group design. The research population is 135 students, while the research sample is 61 students. The sampling technique used cluster random sampling techniques. Data collection methods were questionnaires and tests. Data on ecological attitudes were collected by questionnaire, while data on students' natural science (IPA) learning outcomes were collected by natural science (IPA) learning outcomes test. The data analysis used was Manova. Based on the research that has been conducted, it is concluded that 1) there is a significant effect of the Problem-Based Learning model based on Tri Hita Karana on students' ecological attitude, 2) there is a significant effect of Tri Hita Karana-based Problem-Based Learning model on students' natural science (IPA) learning outcomes, and 3) simultaneously, there is a significant effect of Tri Hita Karana-based Problem-Based Learning model on students' ecological attitudes and natural science (IPA) learning outcomes.
PROBLEM-BASED LEARNING ASSISTED BY SCROLLING PICTURE MEDIA TO IMPROVE THE THIRD-GRADE ELEMENTARY STUDENTS’ SKILLS IN WRITING EXPRESSION
Authors: Mufidah Imroatul , Suyono Suyono , Dewi Radeni Sukma Indra
Published: August 2023

This paper describes the improvement of third-grade elementary students’ writing skills of expression (instruction, announcement, appreciation, and invitation) of grade 3 elementary students by applying a problem-based learning model assisted by Scrolling Picture media. The research method used was classroom action research. The research was conducted in two cycles. Each consists of four stages, namely planning, acting, observing, and reflecting. The results indicate an increasing average of students' skills in writing expressions (instruction, announcement, appreciation, and invitation) in class. An increasing average score of writing expression skills was 71 when the pre-test results increased to 93 in the post-test of cycle I. In this cycle, the average score increased to 22 or 31%. Meanwhile, students who have reached the Minimum Completeness Criteria have also increased from 46% to 89%. In cycle II, otherwise, the student’s skills to write expressions increased compared to the cycle I post-test, which was from 93 in the post-test of cycle I increased to 98 in the post-test of cycle II. In this cycle, the average score increased by 5 or 5.3%. Meanwhile, students who have reached the Minimum Completeness Criteria also increased from 89% to 100%. It is considered satisfying enough for teachers and researchers as the indicator has been achieved successfully. It can be concluded that there is an increasing average value of expression writing skills by applying the problem-based learning model assisted by Scrolling Picture media. The increase is also seen in the students’ enthusiasm and motivation in participating in learning,carrying out responsibility, and conducting cooperation in finishing the tasks provided by the teacher.
The effect of problem based learning (PBL) model on fourth-grade students’ learning outcomes of data presentation
Authors: Sari Dwi Kartika , Ningsih Yarisda
Published: August 2023

The purpose of this study was to determine the effect of the Problem Based Learning model on the learning outcomes of data presentation in the form of a bar diagrams in Class IV SDN Cluster II, Lubuk Kilangan District, Padang City. This research is a quantitative research with the type of quasi-experimental research design. Using purposive sampling technique, we obtained 24 students from class IVA SDN 09 Bandar Buat as the experimental class and 25 students from class IVB SDN 09 Bandar Buat as control class. The results showed that the average experimental class was 82,81 and control class 69.50. The results of the t-test calculation with a significance level of 0.05 obtained tcount > ttable is 4.493 > 2.012, then H0 is rejected and H1 is accepted. The N-Gain test in the experimental class obtained an average of 0.67 while in the control class obtained an average of 0.43. So it can be concluded that the Problem Based Learning model has an effect on learning outcomes in presenting data in the form of bar diagrams in class IV SDN Cluster II, Lubuk Kilangan District, Padang City.
IMPLEMENTATION OF DIFFERENTIATED LEARNING TO IMPROVE EDUCATIONAL SCIENCE AND CHARACTER LEARNING OUTCOMES OF ELEMENTARY SCHOOL STUDENTS
Authors: Astuti Ni Putu Eni , Suastra I Wayan , Arnyana Ida Bagus , Kusuma I Komang Nada
Published: August 2023

This research is qualitative research involving 21 fourth-grade students of SD Negeri 6 Pempatan. Based on the results of interviews with the homeroom teacher for class IV, the minimum competency assessment (AKM) for students' literacy and numeracy requires special interference, so student learning outcomes are very low, especially in science subjects. This study aims to improve student learning outcomes in science subject matter of plant body parts. This study uses differentiated learning involving three learning styles, namely visual, auditory, and kinesthetic. Methods of data collection using observation and interviews. Data analysis method with qualitative descriptive analysis. The results of this study show that the learning outcomes of fourth-grade students at SD Negeri 6 Pempatan have increased. This is evidenced by the increase in learning outcomes between learning 1 and learning 2. In addition, the findings in this study state that student-focused learning activities can improve aspects of the process of how students learn which will have meaningful learning experiences so that at this stage students can develop values from science learning and Pancasila student profiles as a form of strengthening character education.
IMPROVING STUDENTS’ CONCENTRATION AND LEARNING OUTCOMES THROUGH PROJECT-BASED LEARNING ASSISTED BY GAMES AS THE METHOD
Authors: Ghozelin Vika Mutiara , Hadiyanti Agnes Herlina Dwi , Kriswanto Yohanes Bruri
Published: August 2023

This paper is based on the students’ low concentration and learning outcomes. The purpose of the research is to increase the students’ concentration and learning outcomes through the project-based learning model assisted by the game method. The type of research is classroom action research. The research subjects were students at class 4A of SD Kanisius Demangan Baru 1. The research object was the improvement of students’ concentration and learning outcomes through the project-based learning model assisted by the game method. Data collection techniques were obtained through observation, interviews, and tests. The data analysis techniques used were quantitative and qualitative. The research results indicate that the percentage of students' learning concentration before applying the action was still in the low percentage (58.33%), after conducting the first cycle increased to the moderate category level (69.44%), and after conducting the second cycle increased to the excellent category (90.27). The average mastery level of students’ learning outcomes of students before applying the action was still in the low category (57.27). After conducting the first cycle, the student’s learning outcomes increased to the medium category (67.72), and after applying the second cycle increased to the high category (84.09). Thus, students’ learning concentration influences their learning outcomes. It is because if students can focus their attention so they can optimize their ability to respond to the lesson that they learned, so their learning outcomes also increase.
THE USE OF THE PROBLEM-BASED LEARNING (PBL) MODEL IN IMPROVING STUDENTS' CRITICAL THINKING SKILLS ON ECONOMY LEARNING SUBJECTS AT SMA NEGERI 2 KARIMUN
Authors: Deshanty Nurul Annisa , Kartikowati RR. Sri , Syabrus Hardisem
Published: August 2023

This paper discusses the improvement of students' critical thinking skills through the use of the problem-based learning (PBL) model. The research was conducted at class XI IPS 2 of SMA Negeri 2 Karimun. The approach used is quasi-experimental research with a one-group pretest-posttest design. Data collection techniques used observation sheets and questionnaires. Data on the suitability of the learning process with the model are obtained through observation sheets based on PBL syntax and the level of students' critical thinking skills is obtained through questionnaires of students' critical thinking skills. Data analysis techniques used t-tests. The results indicate that the use of the PBL model can improve students' critical thinking skills. It is evidenced from after implementing the PBL model, the students' critical thinking skills increased from the medium category to the high category with a percentage of 53%. Hence, it is expected for teachers to increase the students' critical thinking skills. Thus, it can be applied through the appropriate learning models, one of which is the problem-based learning model.
STRENGTHENING STUDENTS' RELIGIOUS CHARACTER THROUGH RELIGIOUS PRACTICES IN ELEMENTARY SCHOOL
Authors: Arinda Laurita Nurmila , Amrullah Muhlasin , Hikmah Khizanatul
Published: August 2023

This paper describes the strengthening of students' religious character education through religious practices at Al-Islam Plus Krian Elementary School. The research uses qualitative research with a phenomenological approach. The data collection methods used are observation, interviews, and documentation. Data analysis used in the research is data reduction, data presentation, and conclusion. Data validity testing used in the research is triangulation techniques, namely source and technique triangulations. The research results entitled Strengthening Students’ Religious Character through Religious Practices in Elementary School, which consist of religious activities, are the 7S culture, praying before and after learning, reciting hadiths and daily prayers, reciting the Quran, reading asmaul husna, istighosah, praying in congregations (duha, zuhr, asar, Friday), tarjamah, tahfidz Al-Qur'an, and PHBI. The impact of religious practices instilled in Al-Islam Plus Krian Elementary School indicates a significant impact for each student, which can increase students’ understanding and a better understanding related to the benefits of the positive activities they do and will be applied by them in their daily activities in accordance with the Shariah of Islam.
IMPROVING WRITING DRAMA SCRIPT SKILLS USING VIDEO AS MEDIA ON YOUTUBE CHANNEL FOR CLASS VIII STUDENTS OF SMPN 1 SARADAN
Authors: Franciska Dhony , Soleh Dwi Rohman , Nurhidayati Nunung
Published: August 2023

Writing is one of the skills that students must learn in text-based learning in Indonesian learning subjects. Writing drama scripts is one of the writing skills that must be learned by junior high school students, which is one of the competencies contained in Indonesian subjects that must be achieved by students. Therefore, it is important for teachers to apply appropriate learning media in accordance with current technological developments so that teachers and students can achieve the learning objectives. Youtube can be used as a learning medium to improve writing drama script skills for class VIII junior high school students. Type of the research is Classroom Action Research. The collected data are analyzed using quantitative methods and described in a descriptive way. The results indicate that through YouTube, the writing skills of Class VIII students of SMPN 1 Saradan can be improved. It can be seen from the pre-cycle where the number of students' achievement in writing drama scripts was 53.5%, in cycle 1 was 75%, and in cycle 2 was 92.8%. It implies that YouTube is highly effective to increase students' interest and writing skills. Apart from that, YouTube can also help educators to explain the learning materials for students that cannot be described directly.
IMPLEMENTATION OF HIGHER ORDER THINKING SKILLS (HOTS)-BASED EDUCATION TO ENHANCE THE QUALITY OF ENGLISH LANGUAGE FOR STUDENTS AT SDN 1 TIMPAG
Authors: Kuntariati Utik , Paramita Putu Dian Yuliani , Wahyu Gede Eka
Published: August 2023

Quality of education 4.0 is aimed at producing competent and quality human resources in carrying out activities in the industrial world later ( Pohan , 2019). In the current implementation of education in capturing information on the resulting human resources, it is required to obtain information on a very broad scale and human resources are also required to be able to understand various matters, one of which is understanding related to English. In this study, the researcher used a qualitative descriptive method to describe the HOTS concept which would be implemented in English learning activities at SDN 1 Timpag . Qualitative research generally describes the dominant data using words rather than describing phenomena through a numeric number. Based on the results of the research that has been done, some conclusions that can be drawn in this study are that the HOTS indicator learning method is developed in its entirety, there are 6 indicators including Creating, Evaluating, Analyzing, Applying, Remembering and Understanding . At SDN 1 Timpag as a whole there are several implementation indicator ideas that can be improved in the implementation of HOTS in English materials including story telling planning, introduction to animal objects and body anatomy and simple greetings and the use of grammar.
EDUCATOR’S STRATEGY FOR DEVELOPING CREATIVITY IN CHOIR TRAINING
Authors: Qonita Narindra , Sabri Indrar , Yanuartuti Setyo
Published: August 2023

Art education has a huge impact on the development of students’ creativity. In choir training, teachers must also have creativity in conveying learning material so that they can produce good-quality choral groups. The research purpose of this paper is to explain the function of art creativity, the implementation of music and choir learning in schools, and choir training strategies as a means of developing creativity. The research uses a qualitative approach with a descriptive conceptual analysis method. The research uses a conceptual analysis method that examines various literature related to the research objectives. The data analysis techniques are carried out through data reduction, data presentation, and data analysis. The results of data analysis indicate that the art of music education and choir training can be a means of developing creativity for the art performers, either students or teachers. Choir training can encourage students to be creative in expressing the song that is sung. Therefore, it is essential for teachers who have knowledge and skills to seek learning strategies in choir arts to develop students' creativity.
LEARNING IMPLEMENTATION USING CHATGPT MEDIA AT SMA NEGERI 1 SUKABUMI
Authors: Hadian Tantan , Awaluddin Asep Ikhwan , Rostini Deti , Rosa Ade Tutty R
Published: August 2023

This paper describes the use of ChatGPT in learning. The research is a qualitative descriptive study with a case study at SMA Negeri 1 Sukabumi in West Java Province Indonesia. The research begins with a survey, which involves the distribution of questionnaires to 13 learning subject teachers in grade 10 and 69 tenth-grade students who were selected randomly. The questionnaire results were analyzed as a basis for further research, including in-depth interviews, observations, and document studies. Classroom observations were carried out on two teachers who have implemented learning using ChatGPT. To deepen the results of the observations, interviews were distributed to the two teachers and three students who were randomly selected from the observed classes. The research findings indicate that learning using ChatGPT can assist teachers in preparing and directing students in the teaching and learning process. With teacher guidance, students are expected to gain knowledge more comprehensively and deeply by asking specific questions that align with learning objectives. The teacher’s competence to guide students in the use of ChatGPT in terms of n achieving learning objectives determines the achievement of learning outcomes from each student. ChatGPT, as one of the Artificial Intelligence (AI) technologies, offers new challenges in the field of education. The research in this paper provides insights into how this AI technology can be utilized in classroom learning
MODEL OF SCHOOL PRINCIPAL ACADEMIC SUPERVISION BASED ON LESSON STUDY
Authors: Mulyana Nana , Zein Aang Abdulah , Mulyana Rahmat , Rossa Ade T Utty R , Rostini Deti
Published: August 2023

This paper analyzes the lesson study-based school principal academic supervision model to improve the pedagogical competence of teachers at SDN Cipanengah CBM Sukabumi by using a qualitative descriptive research method. The research was conducted by analyzing the stages of Plan, Do, and See. The research begins with interviews and field observations. Planning indicators are 1) identifying plans, 2) formulating objectives and output criteria, 3) compiling schedules, 4) reviewing instruments, 5) carrying out supervision, 6) carrying out supervision of learning outcome assessments, 7) analyzing results, 8) designing the provision of feedback, 9) preparing follow-up planning, and 10) preparing supervision reports. Indicators of implementation and observation are 1) reviewing device administration, 2) reviewing the implementation plan, 3) carrying out supervision, and 4) carrying out assessment supervision of learning outcomes. Indicators of reflection include 1) assessment supervision observation, 2) analysis, 3) academic supervision data analysis, and 4) follow-up. Management of academic supervision is indispensable to increasing teachers’ pedagogical competence. Based on the results of interviews and field observations, it is found that nearly 75.63% had sufficient criteria in making administration of learning tools and carrying out assessment activities.
THE EFFECT OF NUMERICAL LITERACY LEARNING MODEL ON THE FIFTH-GRADE STUDENTS’ MATHEMATICS LEARNING OUTCOMES AT SD NEGERI 156320 SIMPANG TIGA 2
Authors: Simanullang Reno Francius , Silaban Patri Janson , Sari H.S Dyan Wulan , Tanjung Darinda Sofia , Juliana Juliana
Published: August 2023

This paper describes the effect of applying the numerical literacy learning model on students’ mathematics learning outcomes in the material of collecting and presenting data in class V at SD Negeri 156320 Simpang Tiga 2 in the academic year 2022/2023. The research uses a quantitative research method. The research population is 30 fifth-grade students of SD Negeri 156320 Simpang Tiga 2, which consist of 16 male and 14 female students. The sampling technique uses a purposive sample, which distributes in class V with the number of 30 students. The research results indicate that students’ learning outcomes using the numerical literacy model are considered in the good category with an average score of 77.96 and a correlation test result of 0.983, which means rcount (0.983) ≥ rtable (0.361), hence Ha is accepted. Thus, there is a very strong influence between the use of the numerical literacy learning model on students’ mathematics learning outcomes in the material of collecting and presenting data in class V at SD Negeri 156320 Simpang Tiga 2. It can be seen from the results of the T-test research where tcount 28.266 ≥ ttable 1.697 so that it can be stated that Ha is accepted. It shows that there is a significant positive effect from the use of the numerical literacy learning model on students' mathematics learning outcomes in the material of collecting and presenting data in class V at SD Negeri 156320 Simpang Tiga 2 in the academic year 2022/2023.
A STUDY ON VISUAL CONTENT OF INFOGRAPHIC MEDIA HIERARCHY AS TEACHING MATERIAL ON BIOLOGY MATERIAL
Authors: Syarbini Nuzul , Susilawati Elsi , Mardhatillah Nur Agilia
Published: August 2023

The development of technology makes learning media to be interestingly used and makes the material to be easy to understand. An interestingly learning media is infographic media. Infographic media become an effective teaching material in biology learning. Infographic media is closely related to the visual role of hierarchy. Visual hierarchy is one aspect that eases readers to understand information in a structured and systematic manner. The method used in the research is exploratory descriptive. The researcher collected general information related to teaching materials on biology materials and research studies from UIN Alauddin Makassar Biology Education students who used infographic media as teaching materials. Analysis of visual literacy used the theory of visual hierarchy. In terms of visual hierarchy, three teaching material media have been implemented to a good visual hierarchy. The content through a combination of colors, shapes or elements, a good layout, and the selection of created text models becomes contrast. It is because a good understanding of the visual hierarchy can create an infographic that is not only aesthetic but also comfortable for readers to read. Infographic media teaching materials used in viral materials, the phylum Echinodermata, and the digestive system have followed an appropriate visual hierarchy as teaching material media. Of the three infographic media as teaching materials above, of course, they have followed the visual hierarchy.
THE EFFECTIVENESS OF EXPERIENTIAL LEARNING THROUGH JELAJAH ALAM SEKITAR (JAS) APPROACH ON THE NINTH-GRADE STUDENTS’ COGNITIVE LEARNING OUTCOMES AND ACTIVENESS ON THE FUNCTION OF SOIL FOR LIFE AND ITS COMPONENTS LEARNING MATERIAL
Authors: Alfian Alief , Hartatiyati Eny , Agustini Ferina , Yustina Theresia
Published: August 2023

This paper discusses the effectiveness of Experiential Learning on the Jelajah Alam Sekitar approach (JAS) on the ninth-grade students’ cognitive learning outcomes and activeness at SMP Negeri 6 Semarang on the function of soil for life and its component learning material. The research uses the Static Group Comparison method by involving two classes. The control class (9H) uses the lecture method and the experimental class (9G) uses the JAS approach based on Experiential Learning. The cognitive learning outcome data were obtained from multiple choice objective tests (summative assessment), while students’ activeness data were obtained from observation sheets. Data were analyzed by using an independent T-test. The results indicate that the JAS approach was effective in improving students’ cognitive learning outcomes and activeness. It is evidenced by a significant difference between the average score of cognitive learning outcomes in the control class at 89 and in the experimental class at 96.3 with a p-value of 0.043. In addition, there was a difference between the average score of students’ activeness in the control class at 12.3 and in the experimental class at 13 with a p-value of 0.116. Yet, the differences were not significant. Based on the results of the research, it is recommended that teachers can use the JAS approach as one of the alternative learning methods that can improve students’ cognitive learning outcomes and activeness.
DEVELOPMENT OF MATHEMATICS LEARNING MEDIA APPLICATION OF LOGARITHM BASED ON FRAMEWORK7
Authors: Maarif Safiil , Auliyah Firdha Rohmatul
Published: August 2023

Learning carried out by a teacher can be facilitated by the existence of learning media. Learning media serves as a learning aid for students and can be used as a presentation of information on the subject matter, practice questions, or both. Current learning media can be in the form of applications that can be accessed via an Android smartphone. The purpose of this study was to develop logarithmic mathematics learning media using framework7. Framework7 is specifically intended for building hybrid-based mobile applications. The research method used in this research is research and development or Research and Development (R&D). The research design refers to Thiagarajan's research model which has 4 steps (4D), namely define, design, development, and dissemination. This study used data collection instruments in the form of validation sheets from media experts and material experts as well as a questionnaire regarding the logarithmic material learning media trials. According to the results of the development of learning media, it has five components, namely the home page, logarithmic menu list, logarithmic material interface, AP-LOG interface, quiz interface. There are three stages of learning media trials in this study, namely individual trials, small group trials, and large group trials. The results of the testings of instructional media for teachers and students get the results of 10 indicators. so that the learning media are classified under the criteria "suitable for use" and learning media can be used.
DEVELOPMENT OF ELECTRONIC MODULES FOR DERIVATIVES OF ALGEBRAIC FUNCTIONS TO FACILITATE MATHEMATICAL COMPREHENSION ABILITY OF CLASS XI SENIOR HIGH SCHOOL STUDENTS
Authors: Orista Dwi , Armis
Published: August 2023

This study aims to produce an electronic module for derivatives of algebraic functions to facilitate the mathematical comprehension ability of class XI senior high school students who have met the requirements for validity and practicality. The development model used is the ADDIE model, which includes analysis, design, development, implementation, and evaluation. The sample in this assessment is class XII MAN 2 students in Pekanbaru City. Two data collection instruments for the electronic module development are a validation sheet to see the electronic module's validity level and a student response questionnaire to see the electronic module's practicality level. Based on the validation results from three experts, it was obtained that the electronic module has an average score of 3.47 with a very valid category. The trials conducted on students were carried out twice, namely small group trials and then large group trials. Based on the results of a small group trial of students, it was obtained that the electronic module had an average score of 3.67 with a very practical category. Based on the results of a large group trial of students, it was obtained that the electronic module had a score of 3.78 with a very practical category. Therefore, it is concluded that the electronic module of derived material of algebraic functions developed has met the requirements of validity and practicality to facilitate the mathematical comprehension ability of class XI SMA / MA students.
Penggunaan Kompres Aloevera untuk Menurunkan Suhu Tubuh Anak Demam: Case Study
Authors: Pangesti Wilujeng , Murniati Murniati
Published: August 2023

Masalah kesehatan anak merupakan salah satu masalah utama dalam bidang kesehatan yang saat ini terjadi di Indonesia. Salah satu penyakit yang sering menyerang anak - anak adalah demam. Angka kejadian penyakit dengan gejala demam pada anak di Indonesia diperkirakan rata - rata 900.000 kasus pertahun. Pasien yang mengalami demam sering terjadi masalah keperawatan berupa hipertermia atau peningkatan suhu tubuh diatas normal. Terdapat beberapa cara dalam penatalaksanaan demam, baik dengan farmakologi maupun nonfarmakologi. Salah satu penatalaksanaan demam dengan nonfarmakologi adalah penggunaan kompres aloevera untuk menurunkan suhu tubuh pasien demam. Tujuan dalam penelitian ini adalah pemberian asuhan keperawatan pada anak yang mengalami hipertermia yang berfokus pada pemberian kompres aloevera terhadap penurunan suhu tubuh. Desain penelitian ini menggunakan studi kasus pada pasien An. A di Ruang Aster RSUD Prof. Dr. Margono Soekarjo. Hasil penelitian didapatkan bahwa setelah diberikan asuhan keperawatan dengan tindakan pemberian kompres aloevera selama 2 x 15 menit didapatkan bahwa suhu tubuh pasien mengalami penurunan dari 38,00C menjadi 37,50C, sehingga dapat disimpulkan bahwa terdapat pengaruh kompres aloevera dapat digunakan untuk menurunkan suhu tubuh pada pasien demam.
INVESTIGASI PENGARUH PERSON-ORGANIZATION FIT TERHADAP MEANINGFUL WORK PEGAWAI PERGURUAN TINGGI SWASTA DI KABUPATEN LAMPUNG TIMUR
Authors: Bakhri Syaiful
Published: August 2023

Banyak faktor yang bisa menyebabkan munculnya pandangan terhadap kerja yang dilakukan, salah satu di antaranya adalah adanya kesesuaian antara orang dan lingkungan tempatnya bekerja. Tujuan dari paper ini adalah untuk mengetahui pengaruh Person-Organization Fit (P-O Fit) terhadap meaningful work. Penelitian ini menggunakan regresi sederhana untuk menganalisis 25 pegawai yang bekerja di sebuah perguruan tinggi swasta di Kabupaten Lampung Timur, Indonesia. Hasil penelitian menunjukkan bahwa kesesuaian orang-organisasi (P-O Fit) berpengaruh positif dan signifikan terhadap kerja bermakna (meaningful work).
O Novo Acordo da Argentina com o FMI
Authors: Fernandes Marcelo Pereira , Alves Junior Antonio José , Jeronimo de Freitas Alexandre , Christina Wegner Rubia
Published: August 2023

O objetivo deste artigo é analisar o novo acordo da Argentina com o FMI. Mostraremos que apesar da frágil situação econômica do país e do contexto externo adverso, o governo Fernandéz conseguiu concluir um acordo que trouxe algum alívio à Argentina, sem que o governo se comprometesse com reformas estruturais que o Fundo normalmente impõe.
Characterization ofantifungal properties of lipopeptide-producing Bacillus velezensis strains and their proteome-based response to the phytopathogens, Diaporthe spp
Authors: Akintayo Stephen Olusanmi , Hosseini Behnoush , Vahidinasab Maliheh , Messmer Marc , Pfannstiel Jens , Bertsche Ute , Hubel Philipp , Henkel Marius , Hausmann Rudolf , Voegele Ralf T. , Lilge Lars
Published: August 2023

Introduction:B. velezensis strains are of interest in agricultural applications due to their beneficial interactions with plants, notable through their antimicrobial activity. The biocontrol ability of two new lipopeptides-producing B. velezensis strains ES1-02 and EFSO2-04, against fungal phytopathogens of Diaporthe spp., was evaluated and compared with reference strains QST713 and FZB42. All strains were found to be effective against the plant pathogens, with the new strains showing comparable antifungal activity to QST713 and slightly lower activity than FZB42.

Methods: Lipopeptides and their isoforms were identified by high-performance thin-layer chromatography (HPTLC) and mass spectrometric measurements. The associated antifungal influences were determined in direct in vitro antagonistic dual culture assays, and the inhibitory growth effects on Diaporthe spp. as representatives of phytopathogenic fungi were determined. The effects on bacterial physiology of selected B. velezensis strains were analyzed by mass spectrometric proteomic analyses using nano-LC-MS/MS.

Results and Discussion: Lipopeptide production analysis revealed that all strains produced surfactin, and one lipopeptide of the iturin family, including bacillomycin L by ES1-02 and EFSO2-04, while QST713 and FZB42 produced iturin A and bacillomycin D, respectively. Fengycin production was however only detected in the reference strains. As a result of co-incubation of strain ES1-02 with the antagonistic phytopathogen D. longicolla, an increase in surfactin production of up to 10-fold was observed, making stress induction due to competitors an attractive strategy for surfactin bioproduction. An associated global proteome analysis showed a more detailed overview about the adaptation and response mechanisms of B. velezensis, including an increased abundance of proteins associated with the biosynthesis of antimicrobial compounds. Furthermore, higher abundance was determined for proteins associated with oxidative, nitrosative, and general stress response. In contrast, proteins involved in phosphate uptake, amino acid transport, and translation were decreased in abundance. Altogether, this study provides new insights into the physiological adaptation of lipopeptide-producing B. velezensis strains, which show the potential for use as biocontrol agents with respect to phytopathogenic fungi.
Preliminary feasibility study using a solution of synthetic enzymes to replace the natural enzymes in polyhemoglobin-catalase-superoxide dismutase-carbonic anhydrase: effect on warm ischemic hepatocyte cell culture
Authors: Hoq M. , Chang T. M. S.
Published: August 2023

This is a study on a simple solution of chemically prepared small chemical molecules of synthetic enzymes: catalase, superoxide dismutase, and carbonic anhydrase (CAT, SOD, and CA). We carried out a study to see if these synthetic enzymes can replace the natural enzymes (CAT, SOD, and CA) and avoid the need for the complicated cross-linking of natural enzymes to PolyHb to form PolyHb-CAT-SOD-CA. We compared the effect a solution of these three synthetic enzymes has on the viability of warm-ischemic hepatocytes that were exposed to nitrogen for 1 h at 37°C. PolyHb significantly increased the viability. The three synthetic enzymes themselves also significantly increased the viability. The use of both PolyHb and the three synthetic enzymes resulted in an additive effect in the recovery of viability. Increasing the concentration of the synthetic enzymes resulted in further increase in the effect due to the synthetic enzymes.

Implications: In addition to PolyHb, there are a number of other HBOC oxygen carriers. However, only Biopure’s HBOC product has received regulatory approval, but only in Russia and South Africa. None of the HBOCs has received regulatory approval by other countries. If regulatory agencies require HBOCs to have antioxidant or CO2 transport properties, all that is needed is to add or inject the solution of synthetic enzymes as a separate component.
Theoretical analysis of the power generation of pumping cycle kite power systems compared to traditional wind turbines in Aberdeen
Authors: Ye Zhihui , Chaer Issa , Hartungi Rusdy , Ross Marcus
Published: August 2023

The United Kingdom (UK) has pledged to reduce its greenhouse-gas emissions to net zero by 2050. However, in July 2022, the High Court ruled that the government’s net zero strategy failed to outline policies that would enable it to meet the target. As a result, the government published a new plan that sets out opportunities for innovative technologies like Floating Offshore Wind Manufacturing, and hydrogen, which will not only help us reach net zero. For wind, the government’s goal is to develop up to 50 GW of offshore wind by 2030. The challenge of such an expansion is huge. It means the United Kingdom will need to install an estimated 3,200 new, and much larger, wind turbines by 2030—roughly three new turbines every 2 days. Airborne Wind Energy (AWE) systems are part of a new class of wind energy converters that is receiving considerable attention in the renewable energy generation arena. AWE systems benefit from the steadier and stronger wind streams at high altitudes to generate more energy from wind while avoiding the expense of tower construction. This paper presents a feasibility study of using AWE systems in the UK and particularly in the City of Aberdeen to generate renewable energy. The characteristics of wind energy distributions were theoretically investigated by developing a wind speed distribution model, and then the annual power production of a kite system and a turbine system with 30 kW generator were analysed by applying the annual wind profile in Aberdeen to the performance models of these two systems. It was found that the annual power production of the kite system was two times higher than that of a normal turbine system.
A novel prognostic prediction model of cuprotosis-related genes signature in hepatocellular carcinoma
Authors: Shao Ruo-Nan , Bai Kun-Hao , Huang Qian-Qian , Chen Si-Liang , Huang Xin , Dai Yu-Jun
Published: August 2023

Background: Cuprotosis is a recently discovered copper-dependent cell death mechanism that relies on mitochondrial respiration. However, the role of cuprotosis-related genes (CRGs) in hepatocellular carcinoma (HCC) and their prognostic significances remain unknown.

Methods: Based on the recently published CRGs, the LASSO Cox regression analysis was applied to construct a CRGs risk model using the gene expression data from the International Cancer Genome Consortium as a training set, followed by validation with datasets from The Cancer Genome Atlas and the Gene Expression Omnibus (GSE14520). Functional enrichment analysis of the CRGs was performed by single-sample gene set enrichment analysis.

Results: Five of the 13 previously published CRGs were identified to be associated with prognosis in HCC. Kaplan-Meier analysis suggested that patients with high-risk scores have a shorter overall survival time than patients with low-risk scores. ROC curves indicated that the average AUC was more than 0.7, even at 4 years, and at least 0.5 at 5 years. Moreover, addition of this CRG risk score can significantly improve the efficiency of predicting overall survival compared to using traditional factors alone. Functional analysis demonstrated increased presence of Treg cells in patients with high-risk scores, suggesting a suppressed immune state in these patients. Finally, we point to the possibility that novel immunotherapies such as inhibitors of PDCD1, TIGIT, IDO1, CD274, CTLA4, and LAG3 may have potential benefits in high-risk patients.

Conclusion: We constructed a better prognostic model for liver cancer by using CRGs. The CRG risk score established in this study can serve as a potentially valuable tool for predicting clinical outcome of patients with HCC.
Molecular characterization and in silico evaluation of surfactins produced by endophytic bacteria from Phanera splendens
Authors: de Souza Eleane Monaliza de Cerqueira , de Oliveira Maycon Vinicius Damasceno , Siqueira José Edson de Sousa , Rocha Daniela Cristiane da Cruz , Marinho Anderson do Nonato Rosario , Marinho Andrey Moacir do Rosario , Marinho Patrícia Santana Barbosa , Lima Anderson H.
Published: August 2023

The Phanera splendens (Kunth) Vaz. is a medicinal plant that is used in traditional medicine for the treatment of various diseases, such as malaria. This plant presents highly efficient endophytic bacterial isolates with biocontrol properties. Bacillus sp. is responsible for the production of a variety of non-ribosomal synthesized cyclic lipopeptides which highlight the surfactins. Surfactins have a wide range of antimicrobial activity, including antiplasmodial activity. There is scientific evidence that surfactin structure 2d-01 can be a potent inhibitor against a Plasmodium falciparum sirtuin (Sir2) by acting on the Sir2A protein as the target. The Pf genome encodes two known sirtuins, PfSir2A and PfSir2B, where PfSir2A is a regulator of asexual growth and var gene expression. Herein, we have identified six surfactins produced by endophytic bacteria and performed in silico analysis to elucidate the binding mode of surfactins at the active site of the PfSir2A enzyme. Among the characterized surfactins, 1d-02 showed the highest affinity for the PfSir2A enzyme, with binding energy values equal to −45.08 ± 6.0 and −11.95 ± 0.8 kcal/mol, using MM/GBSA and SIE methods, respectively. We hope that the information about the surfactin structures obtained in this work, as well as the potential binding affinity with an important enzyme from P. falciparum, could contribute to the design of new compounds with antimalarial activity.