bluuebunny/crossref_metadata_2025 huggingface dataset:
IN DEFENCE OF THE EXTRAORDINARY APPEAL IN CRIMINAL CASES
Authors: Kil Jan
Published: October 2020

The subject of the article is the analysis of the extraordinary appeal in criminal cases, that has been established by the Act of 8 December 2017 on the Supreme Court. The purpose of the article is to present and analyse the new regulation. The article covers the main issues, which are the most crucial both in law doctrine and the judicial application of law. The author presents the nature of this specific kind of appeal complaint, conditions of its application and the proceedings in this matter. The paper examines each of the issues penetratingly. The study presents the arguments, which justify the implementation of the new extraordinary appeal measure to the Polish legal system. Besides, the author presents proposals connected with the interpretation of the new regulation.
Using Learning Styles for Creating and Personalizing Educational Content in Ubiquitous Learning Environments
Authors: Araújo Rafael D. , Brant-Ribeiro Taffarel , Ferreira Hiran N. M. , Dorça Fabiano A. , Cattelan Renan G.
Published: October 2020

The fact that people behave and learn in a different pace requires individual differences to be properly considered in the teaching/learning process. Among several cognitive theories that could be used for this purpose, a promising one is to explore the use of students' learning styles (LSs), with several research studies indicating that their use has positive impacts on learning outcomes. At the same time, Ubiquitous Learning Environments (ULEs) have the potential to make the multimedia authoring of Learning Objects (LOs) an automated process, resulting on even larger educational content repositories and increasing the need for more adequate presentation strategies to students. This article presents an approach for creating and personalizing LOs through a probabilistic proposal of the Felder and Silverman Learning Styles Model. A prototype of the proposed model was integrated into a ubiquitous educational platform and experimented in real settings. Results indicate the existence of correlations between different types of interactions carried out by students and their respective LSs.
Assistente conversacional para resolução de Problemas Trigonométricos em Linguagem Natural
Authors: Kuyven Neiva Larisane , Vanzin Vinícius João de Barros , Antunes Carlos André , Cemin Alexandra , Silva João Luis Tavares da , Tarouco Liane Margarida Rockenbach
Published: October 2020

Sistemas Tutores Inteligentes (STI) constituem-se, atualmente, em uma área interdisciplinar que investiga como representar modelos de conteúdo instrucional baseado em decisões pedagógicas que consideram as interações dos estudantes. Normalmente, estas decisões são estruturadas a partir da modelagem do estudante, regras que representam o conhecimento do domínio, de um especialista e as estratégias de ensino. Entretanto, a maioria dos STIs preconiza a inferência de nível de necessidade do estudante através do feedback de exercícios e atividades planejados pelo STI, limitando assim a possibilidade interativa do estudante em relação a interface conversacional. Chatbots são então agregados aos STIs fornecendo uma abordagem mais “assistente”, usando técnicas de processamento de linguagem natural e de inteligência artificial, em geral, para gerenciar estas interações. Este artigo apresenta uma abordagem que associa a ideia de Zona de Desenvolvimento Proximal de Vygotsky proporcionando maior grau de liberdade ao estudante, quando possibilita a entrada livre, em linguagem natural, de problemas do domínio não necessariamente pertencente a base de atividades do STI. Neste trabalho, uma abordagem baseada em Deep Learning é usada para mapear automaticamente estes problemas trigonométricos, fornecidos como entrada livre pelo usuário, em modelos de equações, como parte de um projeto maior de um STI na área da Trigonometria (STIT). Esta abordagem traduz diretamente problemas matemáticos em modelos de equações usando um modelo de Rede Neural Recorrente (RNR), combinando um tratamento do conhecimento linguístico para modelar o contexto trigonométrico. Os experimentos conduzidos demonstraram que o modelo proposto classificou corretamente grande parte dos problemas enunciados por um grupo de alunos , fornecendo respostas para os problemas propostos em um formato de resolução passo a passo de um CAS (Computer Algebra System)
Jogo para Mensuração de Habilidades Preditoras de Leitura: Construção e Análise
Authors: Santos Jucelio Soares dos , Araujo de Melo Monilly Ramos , Serey Guerrero Dalton Dario , Abrantes Figueiredo Jorge Cesar , Silva Moita Carla Alexandra
Published: October 2020

O objetivo deste trabalho é apresentar uma descrição do desenvolvimento de um jogo digital, com intuito de melhorar a capacidade de triagem de crianças, identificando sinais de dislexia em avaliações das habilidades cognitivas preditoras do desenvolvimento da leitura. O jogo é uma adaptação do “Teste de Habilidades Preditoras da Leitura”, um instrumento psicométrico construído e validado no Brasil. O jogo é administrado por um algoritmo de seleção adaptativa de itens e projetado para mensurar as habilidades de aliteração, segmentação, memória visual e rima por meio da Teoria de Resposta ao Item. Como resultado, o trabalho evidencia a importância do uso de elementos de jogos associados a avaliação adaptativa informatizada e as suas condições efetivas na aplicabilidade.
Die Rechtsphilosophie Gustav Radbruchs unter dem Einfluss von Emil Lask
Authors: Zhao Jing
Published: October 2020

It is well known that Gustav Radbruch’s philosophy of law is significantly influenced by the neo-Kantian philosophy of Rickert’s student Emil Lask. However, so far, there has been no systematic investigation of the question of which aspects of Lark’s analyses of legal philosophy, cultural philosophy and epistemology are important to Radbruch’s philosophy of law.

The monograph endeavors to close this gap. Its structure orients itself towards a fundamental distinction between the scientific knowledge of the subject and the subject itself. The topic of the first part is the epistemological foundation of the philosophy and science of law; the second part deals with the justification of law itself. In the third part, the developments in the legal philosophical thoughts of Radbruch and Lask are analysed from the point of view of their relationship to the neo-Kantian tradition. The result also offers a new perspective on the much-discussed “transformation” in Radbruch’s legal philosophy.
Die Satzungsgestaltung bei der Europäischen Privatgesellschaft
Authors: Zugelder Stefanie
Published: October 2020

Seit längerem steht in der Diskussion, eine europäische Gesellschaftsform insb. für europaweit tätige KMU zu schaffen. Merkmal dieser „Europäischen Privatgesellschaft“ gem. Verordnungsentwurf der Kommission ist eine weitreichende Satzungsautonomie.

Die Arbeit befasst sich ausführlich mit der Satzungsgestaltung und stellt zunächst das Regelungsgefüge – zwingender Satzungsinhalt vs. Regelungsaufträge - dar. Nach einer Untersuchung von Grundsatzfragen – etwa Auslegungsfragen – nimmt die Autorin zu den einzelnen Satzungsbestandteilen – inkl. sämtlichen Regelungsaufträgen - Stellung.

Im Fall der Wiederaufnahme des Gesetzgebungsverfahrens dient das Werk sowohl der Wissenschaft als auch der Praxis als Leitfaden für Fragen der Satzungsgestaltung.
Nature in the works of Yasunari Kawabata
Authors: Grubor Svetlana
Published: October 2020

There is a strong connection between Japanese culture and nature, to the extent that they can be considered synonyms. Magnificent and cruel nature relentlessly imposed on the inhabitants to reduce their weaknesses and helplessness by cultural work, to make the islands the places where life turns into art and where the creation of a cultural tradition is enabled, in which different and fascinating art forms are expressed. In this paper, the cult of nature is analyzed, which occupies a special place in the works of Yasunari Kawabata. The focus is on the novels Snow Country and Thousand Cranes, in which the perception of nature is given through the prism of Kawabata's view on the fragile beauty of human life before the fear of the whirlpool of transience. Man's attitude towards nature in the works of Kawabata is also reflected in the mysterious role that phenomena in nature have in the formation of characters. The merging of man with nature and the harmony of man and nature are the main aspects of the interpretation of nature in the works of Kawabata, and the multidimensionality of his narration emerges from them.
Moda, imagem e consumo: editoriais de moda como estratégia de comunicação para marcas
Authors: Casagrande Dal Bello Letícia , Scoz Murilo , Da Rosa Lucas , Silveira Icleia , Regina Rech Sandra
Published: October 2020

O presente artigo visou abordar o tema dos editoriais de moda como estratégia de comunicação e consumo para marcas. Traz um apanhado geral sobre consumo e comunicação de moda, bem como uma explicação sobre o que são editoriais, como estes são realizados e para que servem. O artigo foi pautado bibliograficamente em diversos autores com o intuito de esclarecimento a respeito da área e do potencial comunicativo dos editoriais para marcas de moda.
Scientific Findings on the Quality of River Buffalo Meat and Prospects for Future Studies
Authors: Cruz-Monterrosa Rosy , Mota-Rojas Daniel , Ramirez-Bribiesca Efren , Mora-Medina Patricia , Guerrero-Legarreta Isabel
Published: October 2020

The objectives of this review are to detect scientific findings and areas of opportunity in the study of river buffalo meat from primary production through commercialization and to establish future areas of research linked to each step of the meat supply chain to strengthen and improve the production and quality of buffalo meat in the future. Recent studies show that buffalo meat is healthy and that the prevalence of cardiovascular and cerebrovascular diseases is not related to intramuscular fat consumption. The current grand demand for food constitutes an ongoing challenge for agricultural production. Of course, this demand includes meat, but the animal species traditionally destined for human consumption are no longer capable of satisfying requirements. This review detected gaps in studies of the alimentary systems of this species (including its digestive tract) and a paucity of analyses designed to determine the optimum slaughtering age. Identifying –and correcting– practices that foster contamination, reduce the shelf life of buffalo meat, and suggest appropriate conservation and packaging methods during commercialization are two additional pending concerns. This study concludes that marketing buffalo meat represents a great challenge for producers and researchers, one that requires a multi- and interdisciplinary approach that examines in detail every step of the productive chain.
An Approach for Dairy Buffalo Development through Investment in Genetic Improvement
Authors: Soliman Ibrahim , Bahgat Basher
Published: October 2020

Dairy products are an essential source of animal protein, particularly for nutritional vulnerable groups and vegetarians in Asian countries. Therefore, the approach towards increasing the domestic supply of milk is to raise the buffalo milk yield via genetic improvement from the semen of the selected buffalo sire that possesses a high predicted milk difference. Data were collected from Artificial Insemination Centers in Egypt, as a case study, to apply a dynamic mathematical investment model for estimating the rate of return (IRR) to genetic investment. The effective variables in IRR, besides the economic variables, are the reproductive traits and feed efficiency. The estimated most probable level of IRR was feasible, i.e., 19.71%. A worse change in the reproductive efficiency variables, i.e., the aggregate of 10% increase in the number of conception services, age at the First Calving, and the service period, would decrease the IRR by 7.51%. A decrease in feed efficiency by 10% would decrease the IRR by 9%. A worse change by 10% in the feed costs, price of semen, and milk price would decrease IRR by 7%. To import buffalo sires' semen of high predicted milk difference at moderate prices till establishment, domestic genetic merit is required.
Maurice Maeterlinck : du théâtre de la perte au théâtre de la délivrance
Authors: Crêteur Stéphanie
Published: October 2020

L’oeuvre de Maeterlinck (1862-1949) se heurte à la notion d’irréversible tant dans son premier que dans son second théâtre. S’intéressant à ce paradoxe existentiel, tel que défini par Jankélévitch, cet article propose de se pencher sur ce concept et d’analyser quelles résistances lui oppose le théâtre du dramaturge gantois. Passant d’un théâtre de la perte à un théâtre de la délivrance, l’oeuvre de Maeterlinck cherche constamment à trouver une réponse à cette fatalité qui impose à l’homme d’être « tout entier irréversibilité ».
Paul Nougé : une interrogation radicale de la question de l’objet et du langage
Authors: Bianchi Valentina
Published: October 2020

Écrivain singulier, Paul Nougé compose une oeuvre s’étendant sur deux paliers : d’une part, sa création poétique, de l’autre, une importante oeuvre théorique. Il s’y ingénie, par un subtil travail de déconstruction et de décalage, à exprimer les différences qui le séparent de ses confrères surréalistes français, à réaliser des « objets bouleversants », à « défendre » les images d’un grand ami (René Magritte), à réfléchir sur la création poétique de ses contemporains, sur l’art de son temps et sur sa propre création. Cette constante démarche est quasiment sans égale et dit bien ce que peut induire un rapport au réel et à la langue dans un pays où l’Histoire comme la langue paraissent être faites d’abord par les possesseurs français de la norme.
Le miroir de la raison : déconstruction des mythes, assomption de l’humain, nouvel imaginaire du corps et du social dans le théâtre de Michel de Ghelderode
Authors: Itsieki Putu Basey Jean de Dieu
Published: October 2020

Cette relecture de Michel de Ghelderode s’attache à montrer qu’au-delà des motifs de la crise identitaire et du masque, comme à travers les figures de l’angoisse et du tragique, son théâtre porte un projet éthique : servir d’antidote à la déliquescence sociale. Le miroir de la raison que le dramaturge guerrier de l’imaginaire a installé au coeur de son oeuvre lui permet d’analyser les passions profondes de l’humain et les coulisses du social. Ghelderode crée des situations critiques à la faveur desquelles les figures archétypiques mobilisées déconstruisent les représentations socioculturelles et cherchent les possibilités de transformation du réel – social et historique. Les stratégies (mises en abyme, jeux des doubles et contrepoints) exploitées par cette dramaturgie révèlent la vraie nature des mythes, construits sociaux à valeur d’usage, et l’imposture consistant à les ériger en instances de vérité. Les pièces soulignent la nécessité de replacer l’humain au centre de la vie, de lui restituer les rênes de son destin. Ghelderode a produit donc un théâtre de la responsabilité qui vise l’assomption de l’humain, la libération de l’imaginaire du corps et une nouvelle économie du social.
Mystères du réel dans l’oeuvre de Marie Gevers. Motif de l’enchantement arborescent et processus d’écriture poétique
Authors: Ninanne Dominique
Published: October 2020

Cet article explore la présence de l’irréel, à travers la figure de l’arbre, dans la poésie, la narration et les essais de botanique de Marie Gevers. Nous mettrons en évidence des ressorts de l’écriture de Gevers qui contribuent à une perception merveilleuse de cet élément du paysage de Missembourg. D’autre part, nous verrons comment l’arbre, dans sa structure spatiale et temporelle, participe de la fascination de l’auteure pour les rêves. L’étude des textes de Marie Gevers s’appuie sur la lecture de sa correspondance avec Franz Hellens et souligne les liens qui l’unissent au réalisme magique européen.
Hospital Preparedness Level and Policy Implementation Analysis of Hospital Disaster Plan in RSUD Kota Yogyakarta
Authors: Geniosa Belva Prima , Aini Qurratul
Published: October 2020

AbstractHospital is a public facility that must continue on full operation when a disaster occurs. In any disaster situation that results in a surge in patients, hospitals are expected to provide health services for the victims. This study uses  mixed research methods. We combine qualitative methods using in-depth interviews and quantitative methods using questionnaires and hospital safety index scoring. The sample was taken by purposive sampling on hospitals’ management incorporated in the disaster management organization structure. The hospital safety index score result is 62.5%. The knowledge questionnaire results showed 77% percentage, meaning that the staff’s knowledge of disasters was excellent. RSUD Kota Yogyakarta’s Hospital Safety Index result means that it is still in category B. This category means that the hospital still has some risks affecting their maximum function in facing disaster.
Adakah Perubahan Kesintasan Karsinoma Sel Hati di Indonesia?
Authors: Jasirwan Chyntia Olivia Maurine
Published: October 2020

Karsinoma sel hati masih menjadi masalah global dan menjadi penyebab kematian kedua terkait dengan keganasan di seluruh dunia.1 Di Indonesia sendiri pun, karsinoma sel hati (KSH) termasuk dalam penyakit kanker yang menyumbang pembiayaan terbesar ketiga asuransi kesehatan BPJS (Badan Penyelenggara Jaminan Sosial), sedangkan penyakit sirosis hati menempati urutan ke delapan penyakit dengan pembiayaan besar berdasarkan data BPJS Juli 2020.
Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing
Authors: Hoffer Eric D , Hong Samuel , Sunita S , Maehigashi Tatsuya , Gonzalez Ruben L , Whitford Paul C , Dunham Christine M
Published: October 2020

Modifications in the tRNA anticodon loop, adjacent to the three-nucleotide anticodon, influence translation fidelity by stabilizing the tRNA to allow for accurate reading of the mRNA genetic code. One example is the N1-methylguanosine modification at guanine nucleotide 37 (m1G37) located in the anticodon loop andimmediately adjacent to the anticodon nucleotides 34, 35, 36. The absence of m1G37 in tRNAPro causes +1 frameshifting on polynucleotide, slippery codons. Here, we report structures of the bacterial ribosome containing tRNAPro bound to either cognate or slippery codons to determine how the m1G37 modification prevents mRNA frameshifting. The structures reveal that certain codon–anticodon contexts and the lack of m1G37 destabilize interactions of tRNAPro with the P site of the ribosome, causing large conformational changes typically only seen during EF-G-mediated translocation of the mRNA-tRNA pairs. These studies provide molecular insights into how m1G37 stabilizes the interactions of tRNAPro with the ribosome in the context of a slippery mRNA codon.
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
Authors: Jin Haojie , Wang Siying , Zaal Esther A , Wang Cun , Wu Haiqiu , Bosma Astrid , Jochems Fleur , Isima Nikita , Jin Guangzhi , Lieftink Cor , Beijersbergen Roderick , Berkers Celia R , Qin Wenxin , Bernards Rene
Published: October 2020

The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting glutamine addiction using the glutaminase inhibitor CB-839 as monotherapy had a very limited anticancer effect, even against the most glutamine addicted human liver cancer cells. Using a chemical library, we identified V-9302, a novel inhibitor of glutamine transporter ASCT2, as sensitizing glutamine dependent (GD) cells to CB-839 treatment. Mechanically, a combination of CB-839 and V-9302 depleted glutathione and induced reactive oxygen species (ROS), resulting in apoptosis of GD cells. Moreover, this combination also showed tumor inhibition in HCC xenograft mouse models in vivo. Our findings indicate that dual inhibition of glutamine metabolism by targeting both glutaminase and glutamine transporter ASCT2 represents a potential novel treatment strategy for glutamine addicted liver cancers.
M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease
Authors: Fernández-García Sara , Conde-Berriozabal Sara , García-García Esther , Gort-Paniello Clara , Bernal-Casas David , García-Díaz Barriga Gerardo , López-Gil Javier , Muñoz-Moreno Emma , Soria Guadalupe , Campa Leticia , Artigas Francesc , Rodríguez Manuel José , Alberch Jordi , Masana Mercè
Published: October 2020

Huntington’s disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology is most prominent in the striatum, the central hub of the basal ganglia. The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mapped striatal network dysfunction in HD mice to ultimately modulate the activity of a specific cortico-striatal circuit to ameliorate motor symptoms and recover synaptic plasticity. Multimodal MRI in vivo indicates cortico-striatal and thalamo-striatal functional network deficits and reduced glutamate/glutamine ratio in the striatum of HD mice. Moreover, optogenetically-induced glutamate release from M2 cortex terminals in the dorsolateral striatum (DLS) was undetectable in HD mice and striatal neurons show blunted electrophysiological responses. Remarkably, repeated M2-DLS optogenetic stimulation normalized motor behavior in HD mice and evoked a sustained increase of synaptic plasticity. Overall, these results reveal that selective stimulation of the M2-DLS pathway can become an effective therapeutic strategy in HD.
Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model
Authors: Hebras Jade , Marty Virginie , Personnaz Jean , Mercier Pascale , Krogh Nicolai , Nielsen Henrik , Aguirrebengoa Marion , Seitz Hervé , Pradere Jean-Phillipe , Guiard Bruno P , Cavaille Jérôme
Published: October 2020

SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I RNA editing. Because SNORD115 genes are deleted in most patients with the Prader-Willi syndrome (PWS), diminished HTR2C receptor activity could contribute to the impaired emotional response and/or compulsive overeating characteristic of this disease. In order to test this appealing but never demonstrated hypothesis in vivo, we created a CRISPR/Cas9-mediated Snord115 knockout mouse. Surprisingly, we uncovered only modest region-specific alterations in Htr2c RNA editing profiles, while Htr2c alternative RNA splicing was unchanged. These subtle changes, whose functional relevance remains uncertain, were not accompanied by any discernible defects in anxio-depressive-like phenotypes. Energy balance and eating behavior were also normal, even after exposure to high-fat diet. Our study raises questions concerning the physiological role of SNORD115, notably its involvement in behavioural disturbance associated with PWS.
Solving legal puzzles is not easy – supporting creating Data Management Plans in three scientific disciplines: chemistry, economics, and civil engineering
Authors: Szuflita-Żurawska Magdalena , Wałek Anna
Published: October 2020

Open Science Competence Center at the Gdańsk University of Technology Library was established upon the Bridge of Data project at the end of 2018. Our main goals include providing support for the academic community for broad issues associated with Open Science, especially with Open Research Data. Our team of professionals help researchers in many topics such as: "what kinds of data you need to share", "how to make your data openly available to others", or "how to create a Data Management Plan" – that recently has been the most popular and demanding service. 

One of the main challenges to support academic staff with Data Management Plans is dealing with the legal impediments to provide open access and reusing of research data for publicly funded scientific projects. The lack of understanding the legal issues in opening research is a significant barrier to facilitate Open Science. Much public-funded research requires to prepare a Data Management Plan that, among other items, provides information about ownership and user rights.

One of the most common activity for scholars is choosing which license (if any) they are supposed to use in terms of the dissemination the scientific output. However, in many cases, resolving the right license for research data is not enough. Academic staff faces many tensions with a lack of clarity around legal requirements and obstacles. The increasing researchers' need for understanding and describing conflicting issues (e.g. patenting) results in looking for professional and knowledgeable support at the university.

We examine the most frequent legal issues arising among DMPs from the three scientific disciplines: chemistry (e.g. ethical papers), economics (e.g. data value cycle), and civil engineering (e.g. complexity of construction data). In our presentation, we would like to introduce the main identified problems and show how mapping and benchmarking occurring problems among those disciplines help us to establish more efficient legal support for researchers.
The Twin Dilemma
Authors: Johnson Gareth
Published: October 2020

The paper will explore the configuration of a long-running and successful scholar-led, diamond open-access, interdisciplinary journal published by the University of Warwick, which combines knowledge dissemination with contributor developmental goals. Drawing on experiential data, it provides ethnographic insights into the mutually beneficial outcomes derived from recruiting post-graduate researcher ‘associate editors’ to work on the title. It also problematises the balance between potentially exploitative, collaborative editorial production within the context of necessary academic immaterial labour required to operate an interdisciplinary scholar-led title.
Research Methods Deserve Credit and Recognition as a Valuable Research Output
Authors: Ganley Emma
Published: October 2020

Open Research and improved mechanisms to assess and evaluate researchers are both things needed for the scholarly enterprise. We now commonly see open access to research articles, data and code, and citations, which together have moved the needle for achieving both Open Research and research assessment/evaluation. However, one key element that is missing, which is a cornerstone of the research process, is access to a granular description of the methods and approaches used to perform the research. The methods, approaches, and protocols are often incredibly painstaking to develop and optimize and are the key piece needed to fully interpret the results and ensure reproducibility. Too often sufficient information about methods is missing from research articles; the Cancer Biology reproducibility project that aimed to reproduce fifty research studies was stopped after just eighteen were attempted because the efforts to understand what experiments were used was a “hopeless slog”. The research community must incorporate better research method documentation before, during, and after publication to ensure that research efforts are replicable and that the methods can be valued as a standalone research output. protocols.io is a platform, tool, and repository for collaborative method development, storage, and open access publication, which provides an ideal solution to this challenge. By publishing the methods and ensuring they have their own DOIs, any reuse and citations can be tracked and incorporated into research assessment and evaluation processes. Researchers who successfully develop and optimize research protocols deserve to receive credit for this as a distinct output alongside the overarching write-up presented in a manuscript and resulting data.
Driving Green Open Access
Authors: Hole Brian
Published: October 2020

Ubiquity Press was founded to catalyze and accelerate the adoption of open access. Until now we have followed the gold and diamond models, and currently support OA publication in over 700 journals, plus hundreds of book publications per year. We are now expanding our platform to fully support and drive the uptake and effectiveness of green open access also. In this presentation I will explain how we are doing this by integrating an open source repository solution with our platform. I will detail the features  being added to especially enhance green OA, as part of the Advancing Hyku project with funding from Arcadia, a charitable fund of philanthropists Lisbet Rausing and Peter Baldwin, and in partnership with the University of Virginia and the British Library.
Analysis of pedestrian activity before and during COVID-19 lockdown, using webcam time-lapse from Cracow and machine learning
Authors: Szczepanek Robert
Published: October 2020

At the turn of February and March 2020, COVID-19 pandemic reached Europe. Many countries, including Poland imposed lockdown as a method of securing social distance between potentially infected. Stay-at-home orders and movement control within public space not only affected the touristm industry, but also the everyday life of the inhabitants. The hourly time-lapse from four HD webcams in Cracow (Poland) are used in this study to estimate how pedestrian activity changed during COVID-19 lockdown. The collected data covers the period from 9 June 2016 to 19 April 2020 and comes from various urban zones. One zone is tourist, one is residential and two are mixed. In the first stage of the analysis, a state-of-the-art machine learning algorithm (YOLOv3) is used to detect people. Additionally, a non-standard application of the YOLO method is proposed, oriented to the images from HD webcams. This approach (YOLOtiled) is less prone to pedestrian detection errors with the only drawback being the longer computation time. Splitting the HD image into smaller tiles increases the number of detected pedestrians by over 50%. In the second stage, the analysis of pedestrian activity before and during the COVID-19 lockdown is conducted for hourly, daily and weekly averages. Depending on the type of urban zone, the number of pedestrians decreased from 33% in residential zones to 85% in tourist zones located in the Old Town. The presented method allows for more efficient detection and counting of pedestrians from HD time-lapse webcam images compared to SSD, YOLOv3 and Faster R-CNN. The result of the research is a published database with the detected number of pedestrians from the four-year observation period for four locations in Cracow.
Elevation of MPF and MAPK gene expression, GSH content and mitochondrial distribution quality induced by melatonin promotes porcine oocyte maturation and development in vitro
Authors: Zhao Zimo , Yang Ling , Zhang Dan , Zheng Zi , Li Ning , Li Qianjun , Cui Maosheng
Published: October 2020

The MPF and MAPK genes play crucial roles during oocyte maturation processes. However, the pattern of MPF and MAPK gene expression induced by melatonin (MT) and its correlation to oocyte maturation quality during the process of porcine oocyte maturation in vitro remains unexplored. To unravel it, in this study, we cultured the porcine oocytes in maturation medium supplemented with 0, 10−6, 10−9, and 10−12 mol/L melatonin. Later, we analyzed the MPF and MAPK gene expression levels by RT-PCR and determined the maturation index (survival and maturation rate of oocytes). The GSH content in the single oocyte, and cytoplasmic mitochondrial maturation distribution after porcine oocyte maturation in vitro was also evaluated. We also assessed the effects of these changes on parthenogenetic embryonic developmental potential. The oocytes cultured with 10−9mol/L melatonin concentration showed higher oocyte maturation rate, and MPF and MAPK genes expression levels along with better mitochondrial distribution than the 0, 10−6, and 10−12 mol/L melatonin concentrations (p < 0.05). No significant difference was observed in the survival rates when the oocytes were cultured with different melatonin concentrations. The expression of the MPF gene in the oocytes cultured with 10−6 mol/L melatonin was higher than with 10−12 and 0 mol/L melatonin, and the expression of the MAPK gene in 10−6 and 10−12 group was higher than the control (p < 0.05). As far as the embryonic developmental potential is concerned, the cleavage and blastocyst rate of oocytes cultured with 10−6 and 10−9 mol/L melatonin was significantly higher than the 10−12 mol/L melatonin and control. In conclusion, 10−9–10−6 mol/L melatonin significantly induced the MPF and MAPK gene expression; besides, it could also be correlated with GSH content of single oocyte, mitochondrial maturation distribution, and the first polar body expulsion. These changes were also found to be associated with parthenogenetic embryo developmental potential in vitro.
Participatory Rural Appraisal Techniques for Problem Identification and Formulation of Village Agricultural Development Plan of Chosla Village
Authors: Banerjee Rahul , Sheoran Seema , Kumar Saurabh , Sanodiya Rajeshwar , Dhanya V. G. , Samota Mahesh Kumar
Published: October 2020

Participatory Rural Appraisal (PRA) paves a way to understand the grass root level problems faced by farmers following which successful research programs can be proposed. The present study was carried out at Chosla Village of Tonk District in Rajasthan. The PRA tools such as transect walk, agro-ecological mapping, social mapping, time trend, seasonal calendar, gender analysis, timeline, livelihood analysis, technology mapping, consequence diagram and SWOT analysis. Around 20 major problems were identified; in which  aphid in mustard, fragmented lands, non-availability of irrigation water were the top three agricultural problems whereas among the non-agricultural problems: sanitation, lack of higher Education facility and lack of awareness about govt. schemes occupied the top three positions. The action plans for these various problems were formulated by the researchers which would eventually serve as the solutions to improve the socio and economic status of the peoples of the Chosla village.
Effects of Different Fertilizers on Yield and Vitamin C Content of Cauliflower (Brassica oleracea var. botrytis) ̶ A Review
Authors: Belbase Poonam , Bc Lalit
Published: October 2020

Cauliflower is an important winter crop in Nepalese farming community and consumed all over the world. The yield and vitamin C content of cauliflower depends on many factors such as its genotype, cultural practices, environment in which it is growing on and storage after harvesting etc. But among them, the availability, dose and types of fertilizers used play an important role in yield and the amount of vitamin C content in cauliflower. The vitamin C is one of the major Phyto chemicals we obtained from cauliflower and it plays an important role in our physical health. The disease like scurvy is caused due to the lack of ascorbic acid known as vitamin C. It has been proved that consumption of fruits and vegetables rich in vitamin C helps in prevention of cancer and heart disease because it act as a source of antioxidant. The number of studies conducted in the past revealed that the fertilizers having higher amount of nitrogen leads to the formation of less vitamin C on the cauliflower and vice versa.
Genetic Diversity Assessment of Selected Annona muricata L. Germplasm in Sri Lanka
Authors: Samaradiwakara S. H. M. R. N. P. , Samarasinghe W. L. G. , Shantha P. G. S. , Jayarathna K. G. C. N. , Dehigaspitiya P. , Ubeysekera N. M.
Published: October 2020

Annona muricata L. commonly known as soursop is an underutilized fruit crop species in Sri Lanka gaining much importance in the recent past due to its high nutritional and medicinal value. Soursop germplasm collections are available within the country and assessing the genetic diversity is needed to proceed with conservation, detecting promising lines and breeding programs. This study was conducted to assess the genetic diversity of 50 soursop individuals using Inter-Simple Sequence Repeat (ISSR) markers. The study was conducted at Plant Genetic Resources Centre of the Department of Agriculture in Gannoruwa during 2017 to 2019. DNA of the 50 soursop samples were extracted using CTAB method and Polymerase Chain Reaction (PCR) was carried using 13 Inter Simple Sequence Repeat (ISSR) Markers. PCR products were visualized using 1.5 percent Agarose gel electrophoresis under the Biorad Gel documentation system and analyzed using POPGENE 1.31. PCR amplified 139 bands from 13 ISSR markers among which 118 were found to be polymorphic. The polymorphic band percentage was 85 percent while as the average number of bands observed (Na) was 1.8489 and the effective allele number (Ne) was 1.5377. The Nei's gene diversity index (h) was 0.3079. The Shannon Information Index (I) found to be 0.4556. Dendrogram constructed based on the UPGMA method clustered the studied accessions into four major clusters at 80 percent similarity level. Results revealed considerable degree of genetic diversity existed within the studied soursop germplasms at Sri Lanka. Existing genetic diversity within soursop individuals will serve as germplasm bank to identify and utilize potential germplasm resources for conservation and future breeding programs to develop quality soursop varieties in Sri Lanka.
Heavy Metal Analysis of Three Urban Rivers in Enugu, Nigeria
Authors: Atama Chinedu Ifeanyi , Onovo Chioma Julieth , Okeke Chioma Janefrances , Nelson Ossai , Nwani Christopher Didigwu
Published: October 2020

The multiple industrial, domestic, agricultural, medical, and technological applications of heavy metals have led to their wide distribution in the environment, raising concerns over their potential effects on human health and the environment. This work focused on the determination of manganese, chromium, zinc, cadmium, arsenic, mercury, iron and lead concentrations in Abakpa, Iva Valley, and Transekulu Rivers which are close to residential areas in Enugu, Nigeria. The analysis were carried out using atomic absorption spectrometer (AAS). All the heavy metals tested in the three studied locations exceeded the different drinking water limits except zinc which was below secondary drinking water standard of 5.0 mg/l. The levels of mercury and zinc were significantly higher in Abakpa River (0.57 ± 0.112 and 0.881 ± 0.0015 mgl-1 respectively). Iva valley showed higher levels of manganese, chromium, iron and arsenic compared to other rivers studied. The presence in these metals in the water sources are a great risk to humans and the environment.
Biodiesel Production from Human Faeces via Soxhlet Extraction with Hexane and Transesterification Reaction
Authors: Ivwurie W. , Odiganma D.
Published: October 2020

Oil/lipid was extracted from a primary sewage sludge by soxhlet extraction using n-hexane as the solvent. The extracted oil was then converted to biodiesel using transesterification process. The physicochemical properties of the oil/lipids and biodiesel were then determined and compared with literature for lipids and biodiesel parameters, whether they are consistent.

A percentage yield of 18.27 % was obtained for lipids extraction from primary sewage sludge, while for biodiesel production from the extracted lipids, a 66.7% was obtained.

Physicochemical parameters of both lipids and biodiesel obtained, gave values consistent with ASTM standardize, thereby suggesting that primary sludge of human excreta is a veritable/good source for the production of biodiesel, as an alternative source of fuel/energy.
Kinetics of Anaerobic Digestion of Unripe Plantain Peels
Authors: Nweke Chinenyenwa Nkeiruka , Nwabanne Joseph Tagbo
Published: October 2020

This study was carried out to investigate the biogas production obtained from anaerobic digestion of unripe plantain peels (PP) and the kinetics of the digestion process. 400 g of dried and shredded unripe plantain peels were mixed with 200 ml of water and put into 1 L digester and observed for biogas for hydraulic retention time (HRT) of 15 days by the method of downwards displacement. The cumulative biogas volume obtained after digestion was 285 ml. The COD removal efficiency of 72.5% was achieved. The kinetics of PP digestion was evaluated using first order, Monod, Contois and, Grau second-order models. Results showed that the kinetics of anaerobic digestion of PP followed the first-order model with a constant (K) of 0.095 day-1. Monod kinetics was evaluated and the maximum rate of substrate utilization (K), the half velocity constant (KS), endogenous decay coefficient (Kd), biomass growth yield (Y) and, maximum specific microorganism growth rate (µmax) obtained were 0.7615 day-1, 16.20 mg/l, 0.0047 day-1, 0.0112 mgVSS mgCOD-1 and, 0.009 day-1 respectively. These results revealed that inoculation would be required to increase the rate and volume of biogas production. Both first-order and Monod models gave a high coefficient of determination indicating that first order and Monod models can be used to model the digestion of PP. Contois model gave values of µmax and β as 0.011 day-1 and 0.644 mgCOD mgVSS-1 respectively. The result obtained has shown that the digestion of PP did not follow second-order kinetics.
The Use of Ultrasonic Instrumentats in the Dental Practice
Authors: Sergeev Yuriy Andreevich , Markov Alexandr Anatolyevich , Sukmana Bayu Indra , Uinarni Herlina , Matveeva Elena Aleksandrovna , Nalbiy Tuguz Salikhovich
Published: October 2020

The ultrasonic instrumentation in dentistry has been used since the middle of the last century. Improved visualization, ease of operation and precise cutting ability have allowed ultrasonic instruments to be widely used in dentistry. The study considers the possibilities of using ultrasound instruments in various fields of dentistry.

Advantages of ultrasonic instruments include conservative preparation of the cavity, less painful caries removal procedure and minimal noise generation. All these improvements are presented in clinical cases. In addition, the gentle effect on soft tissues is a characteristic feature of ultrasonic devices when applied to operative or orthopedic dentistry during the preparation of the cavity.

Although some issues, such as high-frequency noise, interference to cardiac pacemakers, and low cutting efficiency compared to conventional high-speed or low-speed air-turbine tools, still need to be considered, the results of previous research show that ultrasound tools have an extremely high potential to become a convenient and effective tool for various dental procedures deserve future development.
Analysis of the Turnover of Herbal Medicines in Pharmacy Organizations and Directions for Increasing Sales of Pharmaceutical Products
Authors: Tuguz Nalbiy Salikhovich , Achmad Harun , Kalyakina Inessa Makedonovna , Gnevanov Mikhail Vladimirovich , Subbotin Ivan Gennadievich , Paromova Yana
Published: October 2020

The article analyzes the turnover of herbal products offered by a single pharmacy organization and identifies ways to increase sales of this group of pharmaceutical products. Every year, the popularity of herbal medicines sold in pharmacy chains among the population increases, this is due to the fact that the population in general is gradually moving to a healthy lifestyle nowadays and people prefer to use natural medicines recommended by pharmacists to restore their health.

Considering the need to popularize phytoproducts among the population, the author analyzes the turnover of this group of products, identifies the most popular names of pharmaceutical products in this group and comes to the following conclusion: the largest number of herbal products is represented by the company "Pharmatsvet" (62%), the company "Evalar" is represented by 38%. The authors found that the pharmacy "Pharmacy for the Thrifty" the largest number of implemented drugs (Q1 in the amount of RUB 1239288, in the 2nd quarter in the amount of RUB 1345320) and the lowest sold of mineral waters (in the 1st quarter of selling amounted to RUB 76321, in the 2nd quarter 54321 RUB). On the basis of the analysis of the structure of the range of pharmacy "Pharmacy for the Thrifty" it is established that in the 1st quarter, the largest number were drugs from 39.04%, in the second quarter this figure had risen to 40.9%.

A study of the range of herbal products in the pharmacy "Pharmacy for the Thrifty" showed that the products of the company "Evalar" have a smaller share in the range. This is due to the fact that the cost of herbal teas of this company is much higher than similar herbal teas of the company "Farmatsvet".

Evalar also publishes its own magazine, phytodoctor, which is distributed free of charge. In each magazine, you can find a tea bag that this company produces. At any purchase, each buyer is issued such a magazine, the pharmacist should invite customers to pay attention to the magazine page, where there is a sample of a particular herbal tea and talk about the advantages of Evalar products.
Occupational Health and Safety Training Intervention on Women Health Officers' Safety Behavior at Public Health Center Wolasi, South Konawe Regency
Authors: Russeng Syamsiar S. , Hidayanty Healthy , Malik Adetya Firdyanti , Achmad Harun
Published: October 2020

Background: Public Health Center is a workplace with the potential for occupational safety and health (K3) hazards to its officers, patients and visitors. The level of occupational safety and health risks can be significantly minimized by implementing safety behaviors. Increased safety behavior can be influenced by the practice of having interventions in the form of K3 training. Interventions are carried out based on risk assessments in the workplace.

Objective: This study aims to know the potential for hazards by conducting a risk assessment and assessing the effect of K3 training on actions based on operational procedures, use of personal protective equipment, use of equipment and tools, work posture of officers at public health center of Wolasi South Konawe Regency.

Methods: This research was a passive participatory observational study to assess potential hazards. To assess the effect of K3 training, a quasi experiment is used with a pretest - post test one group design. The sample obtained by 20 respondents with purposive sampling technique.

Results: The results showed that there were 5 potential hazards of low risk categories, 12 potential hazards of medium risk and 18 potential hazards of high risk. The results of statistical test with Wilcoxon signed rank test was that there was a significant effect on behavior based on operational procedures (p = 0.000 <0.05), the use of personal protective equipment (p= 0,000<0,05) and the use of tools and equipment (p = 0.003 <0.05). There was no significant effect on work posture. Conclusion: There is an effect of occupational safety and health training on safety behavior in terms of operational procedures, use of personal protective equipment and the use of tools and equipment for officers at public health center of Wolasi. Public health center of officers are advised to be more disciplined in performing according to the public health center of SOP. It is better for the public health center of to form a K3 team that oversees the implementation of occupational safety and health and also socializes the Minister of Health Regulation number 52 of 2018.