bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of Antiproliferative Activity of Novel Bisurea Derivatives Induces Apoptosis in MDA-MB-231 Breast Cancer Cells
Authors: Vadabingi Nagalakshmamma , Rani ME
Published: June 2024

Breast cancer is the most common type of cancer in women. The prognosis is bleak for triple-negative breast cancer due to the rapid metastasis and ineffective therapeutic options. Finding and developing new medications to treat breast cancer immediately is of the utmost importance. Herein, we investigated the potential mechanisms of bisurea derivatives of p-xylylene diamine cytotoxic activity against breast cancer cells. MTT and microscopic tests were used to measure cell death and cell growth, respectively. It was found out what effects bisurea derivatives of p-xylylene diamine have on caspases. Annexin V/PI staining and cell Analyzer observation of nuclear pieces were used to find cells that had gone into apoptosis. The compound 3c suppressed cell proliferation in the MDA-MB-231 breast cancer cell lines but did not affect normal mammary cells. Additionally, the caspase activities were induced in a higher range in the MDA-MB-231 breast cancer cell lines. Treatment with bisurea derivatives of p-xylylene diamine increased the number of apoptotic cells and led to nuclear pyknosis, fragmentation, and apoptotic body formation in breast cancer cells. The results conclude taken together. Our results suggest that bisurea derivatives of p-xylylene diamine induce apoptosis by activating caspases in MDA-MB-231 breast cancer cells. Moreover, bisurea derivatives of p-xylylene diamine may be an effective strategy for the treatment of breast cancer.
Wastewater issue in IDPs Camps Northwest Syria
Authors: Günal Dr. Ayse Yeter , Taha Khalil Al
Published: June 2024

The study sheds light on the reality of sanitation in informal displacement camps in northwest Syria near the Turkish border. It addresses the methods adopted by the displaced people in collecting, transporting, and disposing of wastewater. It also discusses the challenges facing both the displaced individuals, local authorities and humanitarian organizations working in these camps to implement safe and effective sanitation systems. Additionally, it examines some of the solutions implemented by various organizations and evaluates their efficiency from technical, operational, and economic perspectives. The study concludes the necessity of concerted efforts to implement effective sanitation systems for the safe and efficient collection and transport of wastewater, away from the areas where displaced people gather. Furthermore, it emphasizes the need to mitigate pollutants as much as possible by adopting some of the mentioned methods, or others before final disposal. Moreover, if these wastewater treatments are intended for agricultural irrigation, adherence to relevant Syrian standard specifications for the use of treated water in crop irrigation is essential.
Qualitative Investigation and Screening of Antimicrobial Activity of Stem Extract of Clerodendrum Infortunatum Plant
Authors: Singh Dipendra , Saini Rita , Patil Shivanand
Published: June 2024

Clerodendrum infortunatum is also known as hill glory bower. Clerodendrum infortunatum plants are widely distributed throughout the whole world. Up to now, many species of C. infortunatum have been described in various indigenous systems of medicine that are used in preparation of folklore medicines for the treatment of various life-threatening disease, and more of the Clerodendrum infortunatum have been very well studied for their chemical constituents and biological activities It also used in Unani, Ayurveda, and siddha system of medicine for many years. In the Clerodendrum Infortunatum many compounds, including monoterpentine and its derivatives, sesquiterpene, di-terpenoids, tri-terpentine, flavonoid, quercetin, acacetin, gallic acid, sterols and flavonoid glycoside, phenylethanoid glycoside, steroids and steroid glycosides, cyclohexylethanoids, anthraqunine, cyanogenic glycosides, and others have been isolated and identified. In the present study, Chloroform, pet.ether, and water stem extract Clerodendrum infortunatum obtained by Soxhlet extraction was screened to detect the presence or absence of several bioactive compounds which are reported to cure different diseases. Anti-microbial analysis of stem extract was carried out against lacto-bacillus, E.coli and staphylococcus aureus organisms by agar well diffusion method.It was observed that the zone was recorded against this organism. The results indicates that the chloroform, pet.ether and water extract of C. infortunatum is having anti- microbial efficiency in controlling the microorganisms. So, clerodendrum infortunatum is the plant which are benificial on human health.
Inspection of Hygiene and Vaccination of Broiler Chickens in Maimana City and Pashtonkot District
Authors: Noorzad Mohammad Arif , Saadat Saifullah
Published: June 2024

Poultry farming is a good means of generating income and employment for the people of a country. In addition to having a good income, this industry; it prepares good food for humans, which is economical on the one hand, and on the other hand, chicken products are the best food for humans in Afghanistan and in the world. The purpose of this research is to clarify and explain the current state of hygiene and vaccination of broiler chickens. The research that has been done is a field research and three methods of observation, interview and questionnaire have been used to collect information. The result of the research showed that in 55 percent of Maimane farms, hygiene issues were observed, in 20 percent of farms, the hygiene conditions were relatively good, and in the broiler industry, in the research areas, respectively, ND+IB, IBD- A, IBD-B, and ND were the mentioned vaccines used in both research areas. The only difference between them in Maimana and Pashtankot district was the percentage of their implementation or use, so that ND and IB in Maimana in the period First, 100% was used, while 80% was used in the farms of Pashtankot district, and the amount of other vaccines were also different in Maimanah and Pashtankot districts.
Review Article Propagation of Jojoba, Simmondsia chinensis (Link) Schnneider: Constraints and Prospects
Authors: Bashir Muhammad Azhar , Anjum Muhammad Akbar , Ikhlaq Muhammad , Akram Bilal , Noreen Ammara , Altaf Lubna , Shabir Kashif , Nawaz Mughal Aqib , Ayoub Khan Muhammad Faraz , Amjad Muhammad Ammar , Akhtar Naheed , Altaf Faheem , Rana Muhammad Akmal
Published: June 2024

Jojoba being a dioecious plant has separate male and female plants. Propagation through sexual means i.e., from seed gives more than 50% male plants is a major constraint to being unproductive in future production. Plant sex needs 3-4 years to be identifiable when starts bearing fruit and delays fruiting. 90% of female plants are required when grown on a commercial scale to get a high yield. Being an allogamous species, plants originating from seeds showed huge variation among morphological and yield-related parameters is another constraint that can affect the commercial yield of jojoba. The success of growers and the industry of jojoba is directly dependent on the planting of genotypes that confer high yield and can be multiplied by asexual means via air layering, grafting, cuttings, and tissue culture to yield true-to-type plants is future prospect in jojoba productivity. Different methods of vegetative propagation and their efficiencies concerning jojoba are discussed and reviewed.
FEATURES OF COPD STRUCTURE IN ELDERLY PATIENTS
Authors:   Samarkand State Medical University, Uzbekistan, Shaxnoza Tashmuhammedova , Inomjon Axmadov ,   Samarkand State Medical University, Uzbekistan
Published: June 2024

Currently, there is a clear trend towards an increase in the elderly population. Their share in the population of many countries has exceeded 20%. Prevention of aging is one of the most actively and dynamically developing new areas of medicine in recent years. Factors such as decreased metabolism, dysfunction of the endocrine system and immunity, impaired microcirculation and neurohumoral regulation play a role in the process of natural aging. The age-related decrease in estrogen levels in a woman's body plays an important role in the development of endogenous changes in COPD. Skin aging plays an important role in the mechanism of the overall biological aging process of the body. On the one hand, the mucous membrane of the oral cavity determines metabolic, structural and functional changes common to the entire body, and the condition of the skin as a whole may indicate the degree of aging of the body. On the other hand, the oral cavity is an organ that is constantly in contact with the external environment, as a result of which signs of aging can appear much earlier than in other organs.
THE ROLE OF AEROBIC AND ANAEROBIC MICROFLORA IN THE DEVELOPMENT OF DENTAL MUCOSITIS AND DENTAL PERI-IMPLANTITIS
Authors:   Samarkand State Medical University, Uzbekistan, Shaxnoza Tashmuhammedova , Najmiddinovich Sadriyev Nizom ,   Samarkand State Medical University, Uzbekistan
Published: June 2024

In modern conditions, mixed oral infections: pathogenic and opportunistic bacteria, fungi and protozoa are becoming increasingly important in the emergence of delayed inflammatory complications after dental implantation. Literature data shows that violations of normobiosis in all mucous membranes of the oral cavity are associated with its hygienic condition, dental and periodontal diseases. Local immune protection factors are not of minor importance. To date, the etiological role of the entire group of microorganisms in the appearance of dental mucosa and tooth fairy-implantitis has not been determined. We are talking, first of all, about fungi of the genus Candida, streptococci and staphylococci, the presence of which in the tissues of the oral cavity often indicates immunological diseases in the body, as well as anaerobes found without periodontal signs. tissue disease [2]. In this regard, under certain and not yet fully understood conditions, special attention should be paid to these infectious factors that can lead to the development of inflammatory and inflammatory-destructive complications after surgical interventions carried out to install implants. Rational and effective diagnosis of microbial infection in patients with inflammatory complications after dental implantation remains an unresolved problem, no highly effective pathogenetic methods of its elimination have been developed.
O papel do forame clinocarotídeo na cirurgia de aneurismas da artéria oftálmica
Authors: Cândido Duarte Nuno Crispim , Monteiro Jander Moreira , Barbosa Bernardo , Brito Jose Nazareno Pearce de Oliveira , De Araújo Ricardo Lopes , Almeida Timoteo Abrantes de Lacerda
Published: June 2024

Introduction: The anterior clinoid process may present anatomical variations between individuals, even with changes in the same individual (between sides), mainly related to the formation of a bone bridge between it and the middle clinoid process and the clinoid process later. Recognition of the clinocarotid foramen is important in the treatment of aneurysms of the ophthalmic segment of the internal carotid artery, since the need to perform anterior clinoidectomy may result in inadvertent injury to the vascular structures.
Objective: To review the incidence of clinocarotid foramen and interclinoid bone bridge in current literature.
Method: Integrative review collecting existing information on virtual platforms using the descriptors “brain aneurysm, skull base, internal carotid artery, sphenoid bone” with AND or OR search.
Result: Twenty-five articles were found who met the objective, being read and summarized for this review.
Conclusion: The presence of aneurysms in the paraclinoid region/ ophthalmic segment of the internal carotid artery has a higher incidence in both the clinocarotid foramen and the interclinoid bone bridge.
Quanto há de doença celíaca na síndrome dispéptica?
Authors: Cruz Manoela Aguiar , Czeczko Nicolau Gregori , Rutz Leticia Elizabeth Augustin Czeczko , Cuenca Ronaldo Mafia , Possiedi Rafael Dib , Torres Orlando Jorge Martins
Published: June 2024

Introduction: Celiac disease is an autoimmune condition triggered by the ingestion of and contact with gluten in genetically predisposed individuals. Dyspeptic syndrome, on the other hand, is characterized by chronic upper digestive symptoms. The relationship between these two conditions is the main focus of this review.
Objective: To investigate the prevalence of celiac disease in patients with dyspeptic syndrome based on the analysis of epidemiological characteristics, upper digestive endoscopy, duodenal histology and serology.
Method: Narrative review carried out with information published on virtual platforms in Portuguese and English and analyzed during the period from January 2022 to August 2023. The material for reading and analysis was selected from the SciELO platforms – Scientific Electronic Library Online, Google Scholar, Pubmed and Scopus using the following terms: “dyspepsia, celiac disease, gluten, prevalence” with AND or OR search, considering the title and/or abstract. Afterwards, the full texts were read, including 18 articles.
Results: In dyspeptic patients, the average age was 45.13 years and the female gender was predominant. Symptoms associated with gluten were reported in 6%. The antitransglutaminase antibody was positive, with an estimated prevalence of 1.5%. Considering the Brazilian sample of 100 patients, the diagnosis of celiac disease was made with a prevalence of 3%.
Conclusion: Although the prevalence of celiac disease in dyspeptic patients may be higher than in the general population, results are variable and depend on several factors, including testing methodologies and regional characteristics. This review also highlights the importance of an individualized approach in the investigation of celiac disease in dyspeptic patients, considering aspects such as family history, gluten-related symptoms and autoimmune comorbidities.
LEV NİKOLAYEVİÇ GUMİLEV VE COĞRAFİ DETERMİNİZM
Authors: Turhan Oğulcan Serdar , Kara Abdulvahap
Published: June 2024

Coğrafi determinizm; toplumsal gelişme sürecinin, toplumsal gelişmenin nesnel yasalarının tezahürünün sonucu değil, doğal güçlerin etkisinin bir sonucu olduğunu ileri süren bir kavramdır. Bu teorinin temsilcilerine göre yüzeyin yapısı, iklim, toprak, bitki örtüsü, yaban hayatı ve diğer doğal faktörler, sosyal sistemin doğasını, bazı ülkelerin ekonomik gelişmişlik düzeyini ve hatta insanların fiziksel ve psikolojik özelliklerini doğrudan belirlemektedir. Gumilev bu düşünceleri Avrasya toplumlarının oluşumunu açıklamada kullanmıştır. Gumilev için coğrafi determinizm Batı etnosentrizmine karşı bir kutupta bulunmaktadır. Batı düşüncesine göre coğrafi kader Katolik-Protestan Batı’nın diğer halklara üstünlüğüne sebep olmuştur. Gumilev bu düşünceye kesinlikle karşı çıkmıştır. Bu makalede coğrafi determinizm üzerine bilgi verilip Gumilev’in açısından değerlendirilecektir.
O PAPEL DOS SUJEITOS NA JUSTIÇA RESTAURATIVA APLICADA A CASOS CÍVEIS JUDICIALIZADOS: PROTAGONISMO OU SUBSTITUIÇÃO? PROTAGONISMO OU SUBSTITUIÇÃO?
Authors: Alves da Silva Sandoval , de Azevedo Alves Camille , Renato Siqueira João
Published: June 2024

O presente trabalho objetiva analisar o papel dos sujeitos em círculos restaurativos aplicados a casos cíveis judicializados, contrapondo-se a substituição, característica da jurisdição, ao protagonismo, fundamento das práticas restaurativas. Para tanto, adotou-se o método de abordagem hipotético-dedutivo e, como método de procedimento, o bibliográfico. Verificou-se que, durante o círculo de construção de paz aplicado a casos judiciais cíveis, o papel do advogado obscurece-se, pois não há um terceiro a ser convencido, nem a necessidade de um relato técnico-jurídico sobre os fatos. Todavia, não deriva dessa constatação a total exclusão do advogado, que pode auxiliar e fiscalizar a confecção do acordo, em termos jurídicos, para que ele seja homologado pelo juiz. Portanto, embora os círculos restaurativos exijam o protagonismo dos sujeitos envolvidos no conflito e os advogados atuem em um regime de representação judicial ou “incapacitação” relacional e postulatória perante o juiz, sua participação na Justiça Restaurativa, a posteriori, é importante para a validade do acordo e não deve ser excluída.
Chico Buarque e o espaço do sagrado
Authors: Constantino Paulo Roberto Prado , Camargo Filho Jorge Geraldo de
Published: June 2024

Este artigo pretende desenvolver uma análise lírica das composições de Chico Buarque, sob o aspecto da presença e espaço do sagrado nas letras em quatro de suas canções, “Dueto, “Cálice”, “Salmo” e “Sinhá”. Empregou-se a pesquisa documental e bibliográfica, com referencial suportado por estudos multidisciplinares. As canções de Buarque, como obras que fundem o musical, o literário e o poético, apresentam riqueza temática e uma complexa trama, onde se entrelaçam elementos culturais, religiosos e históricos para comentar aspectos da sociedade brasileira. Ao examinar esta poética nas canções, o estudo não apenas contribui para revisitarmos uma vez mais a obra do artista, como oferece um percurso para a educação musical, o acesso à literatura e o letramento, que pode ser útil à educação básica e também à educação especializada.
Sorvetes plant-based: importância e ingredientes substitutos do leite - uma breve revisão
Authors: Gottardi Shirley Prestes de Macedo , Massarolo Kelly Cristina , Scalcon Araceli
Published: June 2024

A procura por alimentos saudáveis está em ascensão, assim como o interesse pela melhoria da qualidade de vida e pela inclusão na dieta de alimentos com maior valor nutricional ou que atendam às restrições alimentares. Entre os grupos restritivos, destacam-se os alimentos sem lactose, sem proteína do leite, sem glúten e com baixo teor calórico, entre outros. A alergia à proteína do leite, uma reação adversa do sistema imunológico, acomete entre 2% e 6% da população. A dificuldade em encontrar alternativas alimentares para esses grupos representa uma oportunidade de inovação em formulações. Portanto, o objetivo deste trabalho foi investigar os ingredientes utilizados na produção de sorvete vegano e destacar o efeito desses ingredientes nas características físico-químicas e sensoriais dos produtos finais, por meio de um estudo bibliográfico. A metodologia empregada foi uma pesquisa qualitativa, baseada em uma revisão bibliográfica de publicações científicas em periódicos, anais de eventos, entre outros, utilizando palavras-chave para busca. Dentre os ingredientes mais utilizados para substituir o leite estão: inhame, ervilha, castanha de baru, castanha de caju, extrato de coco, batata doce, inhame, mamão, chia, proteínas de soja e de arroz. A produção de sorvetes plant-based para o público com restrição alimentar tem elevado potencial para o desenvolvimento de novos produtos. Os resultados encontrados revelam um alto potencial de mercado para esses produtos, com os sorvetes veganos recebendo uma boa aceitação dos consumidores e atendendo aos padrões físico-químicos e microbiológicos exigidos pela legislação vigente.
Desenvolvimento e validação de simulador de sondagem vesical masculina para uso no ensino de habilidades
Authors: Silva Lêda Lima da , Moura Ana Laura Guimarães , Pinheiro Ivemdolar Antunes , Silva Silvana Cristina Rodrigues da , Lima Ramon Costa de , Brito Marcus Vinicius Henriques , Pantoja Mauro de Souza , Barros Charles Alberto Villacorta de
Published: June 2024

Os simuladores médicos desempenham um papel crucial na formação de profissionais de saúde, oferecendo treinamento seguro e eficaz para procedimentos clínicos e cirúrgicos e preparando os estudantes para situações reais na vida profissional. A validação prévia é essencial para garantir sua eficácia, enquanto a avaliação subjetiva por profissionais possibilita a reprodução precisa de situações clínicas, promovendo um ambiente de aprendizado prático e efetivo na educação médica. Esta pesquisa visa validar um modelo de treinamento de baixo custo para a habilidade de sondagem vesical masculina, sem o uso de animais, com a avaliação dos docentes e o depósito da patente do modelo. O estudo foi dividido em três fases: idealização do modelo e criação do protótipo; validação por docentes de medicina e pesquisa de produtos similares em bancos de patentes. O simulador obteve uma aprovação de 88,6%, sendo considerado válido para uso no ensino, com uma média de 23,9 pontos na escala utilizada (escala Likert adaptada) e uma taxa de Cronbach de 0,72. Após a validação, foi reconhecido como modelo de utilidade pelo Instituto Nacional da Propriedade Industrial (INPI). A diversidade de abordagens na validação de simuladores destaca a importância de considerar tanto as características técnicas quanto a experiência dos usuários, evidenciando a necessidade contínua de investimento em pesquisa e desenvolvimento para aprimorar as ferramentas de simulação e proporcionar uma formação médica mais completa e eficaz.
Risco ergonômico para os profissionais de limpeza em empresas terceirizadas
Authors: Santos Maria Isabel Silva , Lengruber Marcely Ribeiro , Silva Junior Milton Domingues da , Ferreira Ana Rita Alves , Silva Alessandra de Oliveira Borba , Werle Tatiana Souza da Silva , Pinto Alinna Lage Ferraz , Passos Joanir Pereira
Published: June 2024

Objetivo: Buscar publicações dos últimos cinco anos sobre os estudos ergonômicos de profissionais de limpeza de empresas de terceirização de serviços. Método: revisão integrativa, realizada nas bases LILACS, Scopus, PUBMED e CINAHL em novembro 2023. Os descritores “ergonomia”, “serviço de limpeza” e seus sinônimos foram combinados por operadores booleanos. Resultados: Dos 90 artigos analisados, foram escolhidos 08 para construção desta revisão. Evidenciou-se os trabalhadores que executam as atividades de limpeza possuem o mesmo perfil socioeconômico estando expostos aos riscos ergonômicos e mais suscetíveis a desenvolver lesões osteomusculares. Conclusão: Se faz necessário ampliar as pesquisas sobre os trabalhadores de limpeza e fornecer melhores condições de trabalho e ferramentas ergonômicas para mitigar os riscos existentes no ambiente de trabalho.
Estudios del Futuro Tecnológico: Definiciones hacia un Modelo Conceptual de Prospectiva
Authors: Mejía Trejo Juan
Published: June 2024

El Dr. Juan Mejía Trejo egresó en 1987 como Ingeniero en Comunicaciones y Electrónica por la Escuela Superior de Ingeniería Mecánica y Eléctrica (Unidad Profesional Culhuacán) del Instituto Politécnico Nacional, obteniendo en el 2000, su Maestría en Administración de Em-presas en Telecomunicaciones por parte del Instituto Tecnológico de Teléfonos de México y es graduado en 2010 como Doctor en Ciencias Administrativas por la Escuela Superior de Comercio (Unidad Profesio-nal Santo Tomás) del Instituto Politécnico Nacional. En su desempeño profesional, participó durante 21 años, en di-versas áreas de Ingeniería y Operación en Teléfonos de México, fungiendo como Gerente de Explotación de Planta Interna en División Occidente.En su participación como docente en el Centro Universitario de Ciencias Económico Administrativas (CUCEA) de la Universidad de Guadalajara (UDG), es miembro de Cuerpo Académico Consolidado: UDG-CA-484 de, Competitividad, Gestión del Conocimiento y Sustentabilidad, con la Línea de Investigación: Negocios Internacionales, Competitividad, Gestión del Conocimiento e Innvación Tecnológica.Desde 2010, es colaborador de la Asociación Mexicana de Directivos de la Investigación Aplicada y el Desarrollo Tecnológico, A.C. (ADIAT), adscrito en el Programa Nacional para la Formación de Vinculadores Tecnológicos (FORVITEC) y miembro de la mesa de Innovación de la Academia de Ciencias Administrativas (ACACIA), en el rubro de Procesos de Cambio y Desarrollo Organizacional; por último, cabe agregar, que es aspirante a ingresar al Sistema Nacional de Investigadores (SNI) México 2011.
USINAS REVERSÍVEIS DE ENERGIA NO BRASIL: UMA ABORDAGEM DE ENGENHARIA ELÉTRICA
Authors: Miler Douglas de Andrade , Galiasi Felipe da Silva Cezar , Monteiro Flavio Henrique Vicente , Santos Marcelo da Silva , Silva Vicente Israel
Published: June 2024

Com o desenvolvimento e crescimento da população, a demanda por energia aumenta a cada ano. Em resposta a essa necessidade crescente, novas soluções estão sendo desenvolvidas. Com base nisso, o objetivo deste trabalho é apresentar um meio alternativo para geração de energia: as usinas reversíveis. Essas usinas operam tanto como geradores quanto como consumidores, convertendo energia e armazenando-a. Durante os períodos de baixa demanda, elas armazenam o excedente como energia potencial gravitacional e o aproveitam nos picos de consumo reduzindo os custos. Ao fazer isso, as usinas reversíveis contribuem para equilibrar oferta e demanda, otimizando o fornecimento de energia elétrica e reduzindo os custos durante os períodos de maior consumo.
REPRESENTAÇÕES SOCIAIS DE PROFISSIONAIS DA SAÚDE DA ATENÇÃO PRIMÁRIA SOBRE O CUIDADO DE PESSOAS COM TRANSTORNOS MENTAIS
Authors: Santos Thais Fátima Ameixieira , Saidel Maria Giovana Borges
Published: June 2024

Este estudo qualitativo e interpretativo teve como objetivo compreender as representações sociais de profissionais da Atenção Primária à Saúde sobre o cuidado de pessoas com transtornos mentais em um município de grande porte no interior de São Paulo. A amostra foi selecionada intencionalmente, com coleta de dados por meio de entrevistas semiestruturadas, e a saturação teórica foi utilizada para determinar o tamanho da amostra. A análise de dados foi realizada por meio da técnica de análise de conteúdo temática, utilizando o software NVivo 1.3 Release. Os resultados revelaram que a escuta ativa e o acolhimento são ferramentas essenciais no cuidado a pessoas com transtornos mentais. Embora os profissionais considerem sua formação acadêmica insuficiente em saúde mental, reconhecem o conhecimento como uma estratégia para prevenir estigmas. Esses estigmas são frequentemente associados às representações dos profissionais em relação às pessoas com transtornos mentais na APS, resultando em consequências pessoais e limitações no cuidado. Em síntese, os profissionais da APS demonstram a importância da escuta ativa e do acolhimento no cuidado a pessoas com transtornos mentais, apesar das lacunas em sua formação acadêmica. A identificação recorrente de estigmas destaca a necessidade contínua de sensibilização e capacitação para promover um cuidado mais humano e eficaz.
MÁSCARA E IMPROVISAÇÃO: AFETOS E PERCEPTOS NO PROCESSO DE CRIAÇÃO NO CONTEXTO PANDÊMICO
Authors: Kellermann Mariana Marques , Rodrigues Glaise de Nazaré Ramos Bastos
Published: June 2024

A pesquisa desenvolvida pelo Grupo de Pesquisa “Educação Lúdica” (UFPA/CNPq), objetivou realizar reflexões sobre a metodologia empregada na execução do Curso de Extensão “Máscara e Improvisação: a interpretação do movimento” ministrado através de plataformas virtuais. As questões: É possível desenvolver pesquisa no atual contexto pandêmico? Quais estratégias podem subsidiar a continuidade das pesquisas do grupo? nortearam a pesquisa. O objetivo da pesquisa consistia em desenvolver, mediado pela ludicidade, uma formação que possibilidade o processo criativo por meio de ações do movimentar, do interpretar, de tomar ciência do espaço, de tomar ciência de si e do outro e de como se sentir sensibilizado, mesmo em um contexto de interação virtual. A pesquisa seguiu uma abordagem qualitativa com a utilização da metodologia do estudo de caso. Os resultados alcançados consistem no desenvolvimento de trabalhos reflexivos acerca do fazer arte e como ela é propulsora de transformação pessoal e social. A conclusão que se alcança no momento é que a arte do mascaramento pode ser acionadas para transformação entrelaçando a ética, a estética e a política, dando forças a todos a superação de desafios que possam emergir ora no âmbito pessoal, ora na esfera coletiva, pois a máscara como obra de arte é um ser de sensações e como tal, pode percorrer caminhos de possibilidades e de muitas descobertas, galgando de certa forma, o que realmente queremos que é propagar o ensino das artes de forma lúdica e de maneira transfronteiriça.
Efectos de la inflación en Belice a causa de la pandemia por COVID-19
Authors: Hernandez Odelys Xeomari , Beltrán López Robert , Rodríguez Díaz Eustacio , Alpuche Pérez Enrique
Published: June 2024

Belice sufrió grandes cambios políticos, sociales y económicos debido a la pandemia por COVID-19 que dio inicio en 2020. Esta investigación analizó el impacto económico que tuvo la pandemia en Belice a partir de la inflación de 2019 a 2022. Para la recolección de datos se indagó en protocolos establecidos, falta de fronteras, cambio en los salarios y tasa de desempleo con la finalidad de identificar los factores que afectaron la inflación en Belice. Además, se aplicó un cuestionario a 213 belicenses para analizar los datos recogidos de las fuentes de información fiables del Instituto de Estadística de Belice y de otras investigaciones realizadas en países del Caribe y Norte América. Se detectó que la inflación no fue afectada por el desempleo del país.
A guide to the new RIBA Building Contracts
Authors: Davies Ian
Published: June 2024

Architect Ian Davies offers a brief guide to the new RIBA Building Contracts which have been tailored to domestic or simple commercial projects.
Managing Health & Safety Risks (No. 37): Electrical isolation
Authors:   The Institution of Structural Engineers' Health and Safety Panel
Published: June 2024

This article provides more detail on the need for electrical isolation, and is of particular relevance to refurbishment and demolition projects.
AQUAPONIA COMO RECURSO PARA A ALFABETIZAÇÃO ECOLÓGICA E A EDUCAÇÃO INTEGRAL NA EDUCAÇÃO BÁSICA
Authors: Miyazaki Yoshiaki Nogueira , Camargo Renan Pinton de , Ponte Maxwell Luiz da
Published: June 2024

No contexto do ensino de Ecologia na educação básica do Brasil, identifica-se uma lacuna, sendo criticado por ser predominantemente teórico e baseado na memorização de conceitos, o que compromete o desenvolvimento de habilidades socioemocionais e a formação de uma ética ambiental nos estudantes. Diante desse cenário, propõe-se a utilização do sistema aquapônico como recurso didático para promover a alfabetização ecológica e contribuir para a formação integral dos estudantes. A técnica, integrando aquicultura e hidroponia, destaca-se por seu potencial pedagógico pouco explorado na educação básica, proporcionando uma abordagem prática e integrada às questões ambientais. A pesquisa apresenta possíveis práticas de ensino com o sistema aquapônico, relacionando-as às diretrizes curriculares da BNCC, os conceitos-chave e princípios para a alfabetização ecológica e aos quatro pilares da educação da UNESCO. Conclui-se que o potencial contributo do uso do sistema aquapônico vai além de dinamizar aulas ou torná-las práticas, promovendo uma abordagem integrada às questões científicas, tecnológicas e sociais, reiterando a importância da sua disseminação mediante políticas intersetoriais para formação de professores e integração com comunidades e famílias
EDUCAÇÃO EM TEMPO INTEGRAL
Authors: Vitoria Elise Pereira
Published: June 2024

O presente artigo aborda a política e as experiências de educação integral em tempo integral no Brasil e pretende explorar as concepções de qualidade do ensino que permeiam políticas e iniciativas de educação integral e  escola  de  tempo  integral por  meio  de  artigos  que debateram possíveis  relações entre a ampliação  do tempo de permanência na escola e incrementos na qualidade do ensino. A metodologia utilizada é o método bibliográfico, que se refere à pesquisa sistemática baseada em materiais publicados em livros, revistas, jornais, redes eletrônicas, ou seja, materiais acessíveis ao público. A escola em tempo integral é uma possibilidade efetiva de melhorar a qualidade do ensino, contudo, indica que esforços precisam ser adotados para que outras dimensões da educação escolar sejam atendidas para fortalecer e estimular todo o potencial desta política educacional em incrementar melhorias da qualidade do ensino. Como estudo de caso, acompanhamos a EEEF. Cândida Silveira Haubmann,  escola rural, mutisseriada, que tem este formato, através das vivências realizadas durante a participação no programa Residência Pedagógica. Nesse cenário constatamos que a escola por ser de tempo integral, localizada em zona rural tem muitas potencialidades a serem exploradas, porém ainda não consegue ser considerada uma escola de educação integral.
Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence
Authors: Sinha Sony , Ramesh Prasanna Venkatesh , Nishant Prateek , Morya Arvind Kumar , Prasad Ripunjay
Published: June 2024

Ocular surface squamous neoplasia (OSSN) is a common eye surface tumour, characterized by the growth of abnormal cells on the ocular surface. OSSN includes invasive squamous cell carcinoma (SCC), in which tumour cells penetrate the basement membrane and infiltrate the stroma, as well as non-invasive conjunctival intraepithelial neoplasia, dysplasia, and SCC in-situ thereby presenting a challenge in early detection and diagnosis. Early identification and precise demarcation of the OSSN border leads to straightforward and curative treatments, such as topical medicines, whereas advanced invasive lesions may need orbital exenteration, which carries a risk of death. Artificial intelligence (AI) has emerged as a promising tool in the field of eye care and holds potential for its application in OSSN management. AI algorithms trained on large datasets can analyze ocular surface images to identify suspicious lesions associated with OSSN, aiding ophthalmologists in early detection and diagnosis. AI can also track and monitor lesion progression over time, providing objective measurements to guide treatment decisions. Furthermore, AI can assist in treatment planning by offering personalized recommendations based on patient data and predicting the treatment response. This manuscript highlights the role of AI in OSSN, specifically focusing on its contributions in early detection and diagnosis, assessment of lesion progression, treatment planning, telemedicine and remote monitoring, and research and data analysis.
Promoviendo habilidades socioemocionales a través de programas de mindfulness en tercer nivel de educación: Una revisión literaria
Authors: Espinoza Bravo María Gabriela , Cabezas Cabezas Roberto Fernando , León Sinche Julio Cesar , Carguaytongo Cuenca Martha Zoraida
Published: June 2024

La integración de programas de mindfulness en el ámbito educativo ha ganado interés en las últimas décadas, especialmente por su potencial para mejorar el bienestar general y las habilidades socioemocionales de los estudiantes. El objetivo es explorar la implementación y los efectos de los programas de mindfulness en la educación de tercer nivel, considerando su efectividad en el desarrollo de habilidades socioemocionales, identificando las mejores prácticas y componentes clave que contribuyen a su éxito en instituciones de educación superior. La metodología es de carácter cualitativo, donde se usó analizaron 15 libros, artículos académicos y estos se los relaciono con las entrevistas realizadas a cinco docentes de educación superior o de tercer nivel.  El principal hallazgo de la exploración de la implementación de programas de mindfulness en la educación de tercer nivel es su efectividad en el desarrollo de habilidades socioemocionales de los estudiantes. Este hallazgo se basa en la evidencia tanto de la revisión bibliográfica como de las entrevistas con docentes, que destacan la reducción del estrés y la ansiedad, así como el aumento de la autoconciencia, la empatía y la regulación emocional como resultados positivos de estos programas. La derivada de estos hallazgos es que la flexibilidad, la adaptabilidad y la integración de modelos teóricos sólidos son fundamentales para el éxito de los programas de mindfulness en el nivel terciario de educación. Los programas deben ser diseñados de manera que puedan ajustarse a las necesidades y preferencias de los estudiantes, así como a las características específicas del entorno educativo.
THE CONSTITUTIONAL COURT’S DECISION ON THE AMENDMENT OF LAW NO. 1/1974 ON MARRIAGE
Authors: Muhibbin Moch. , Triadi Dr. Irwan
Published: June 2024

This research was conducted to determine the impact of Constitutional Court Decision No. 46/PUU-VIII/2010 related to the position of children out of wedlock and Constitutional Court Decision No. 69/PUU-XIII/2015 on marriage agreements on the amendment of Law No. 1/1974 on marriage. This research used juridical normative methods with a statutory approach. In addition, the data analysis used is descriptive qualitative. The results of the research indicate that there are three decisions of the Constitutional Court with the verdict “granted”, including the following Constitutional Court Decision Number 46/PUU-VIII/2010; Constitutional Court Decision Number 69/PUU-XIII/2015; and Constitutional Court Decision Number 22/PUU-XV/2017 regarding the age limit of marriage. Constitutional Court Decision Number 22/PUU-XV/2017 has been followed up with the amendment of Law No. 16/2019 concerning Amendments to Law No.1/1974 on Marriage. However, Constitutional Court Decision Number 46/PUU-VIII/2010 and Constitutional Court Decision Number 69/PUU-XIII/2015 were omitted in the Law No. 16/2019 amendment. Therefore, the law-forming apparatus needs to implement the legislative review and executive review mechanisms that can be used as an effort to amend a statutory regulation through the legislative and executive institutions, in this case, Constitutional Court Decision Number 46/PUU-VIII/2010 and Constitutional Court Decision Number 69/PUU-XIII/2015. In addition, it is also essential to strengthen the system for monitoring the follow-up of Constitutional Court decisions that are final and binding.
ANALYSIS OF THE CANCELLATION OF CONSUMER DISPUTE SETTLEMENT DECISION BOARD SURABAYA NUMBER: 25/BPSK/XI/2020
Authors: Regina Mariska , Munawaroh Siti
Published: June 2024

The Consumer Dispute Settlement Board (BPSK) is one of the institutions tasked with resolving consumer disputes. This research aims to find out the existence of BPSK can be part of equitable justice, especially for consumers who have suffered losses by business people because disputes between consumers and business people are usually small nominal so that consumers are reluctant to file disputes in court because it is not comparable between the cost of the case and the amount of losses experienced. The method used in this research is the juridical normative method. This is based on the consideration that the specification of this research is descriptive analytical, that is, describing existing legal problems based on applicable laws and regulations associated with legal theories and cases of consumer disputes which are the subject matter of the research. The results of this research, such as (1) the main task of BPSK is to resolve disputes between consumers and business actors; (2) Surabaya District Court Decision Number: 1212/Pdt.Sus.-BPSK/2020/PN.Sby., which canceled the Surabaya City BPSK Decision Number: 25/BPSK/XI/2020, according to researchers, this decision was right. One of the reasons that can be used to cancel the decision is the consideration of the judge who accepted the applicant’s reason that there was no legal relationship between the applicant and the respondent.
COMPARISON OF INVESTMENT AGREEMENT LEGALITY USING BITCOIN MEDIA IN INDONESIA
Authors: Evryansyah Muhammad Bilal , Wahjuningati Edi
Published: June 2024

There has been a huge growth in the value of bitcoin in Indonesia, especially during late 2017. Many people are interested and aware of this phenomenon related to Bitcoin that operates only as a digital system and has no physical existence. This research will further discuss Bitcoin as an investment agreement object. This research uses a normative legal research method with a conceptual approach that refers to the law. This research aims to determine and analyze the comparison of the validity of investment agreements that use Bitcoin as an investment object in several countries. In addition, to find out and analyze the legal protection of the parties who make Bitcoin buying and selling transactions using the Indodax website facility under Indonesian law. The results of this research indicate that there are differences of legal basis to regulate Bitcoin transaction agreements between El Salvador and Indonesia. In El Salvador, the Bitcoin Law is set as the legal basis for regulating Bitcoin transaction agreements. Whereas in Indonesia, the legal basis for regulating Bitcoin transaction agreements is the Commodity Futures Trading Supervisory Agency Regulation No. 5/2019 concerning Technical Provisions for the Implementation of the Crypto Asset Physical Market on the Futures Exchange.
THE CASE REPORT OF A COVID-19 PATIENT WITH LATE DIAGNOSIS OF HIV
Authors: Desdiani Desdiani
Published: June 2024

Coronavirus 2019 (Covid-19) is a disease that causes hyper-systemic inflammation affecting the respiratory system and extrapulmonary system. Covid-19 causes non-specific clinical health disorders in immunocompromised patients who often do not react to treatment. One case of a 58-year-old Indonesian man with a positive GeneXpert test result for Covid-19 but did not react to routine Covid-19 first-line therapy. The patient's anti-HIV test was confirmed positive, with an absolute CD4 of 13.7 cells/L, lactate dehydrogenase of 385 U/L, and procalcitonin of 0.24 ng/mL. The patient was treated with antibiotics, remdesivir, dexamethasone, heparin, anti-HIV treatment, and other supporting medications. The PCR test was negative ten days later, the laboratory and radiology results had also stabilized. In this case, the possibility of co-detection of Covid-19 with immune system diseases such as HIV is emphasized, and the importance of further testing for suspected patients to provide accurate treatment. It is quite difficult to determine HIV risk factors, and the limited treatment options for Covid-19 and it may not be effective. This case highlighted the possibility of misdiagnosis, especially during an infectious disease pandemic, and the importance of extended testing, even if the immunological state is disregarded in immune-compromised patients.
Review on Fisheries Resources and the Effect of Marine Pollution in Coastal Waters of Pakistan
Authors: Wasim Muhammad Wasim Khan , Abbas Ghulam
Published: June 2024

The people who reside in the Balochistan and Sindh Provinces rely on the abundant fish and shellfish resources in Pakistan's coastal waters for food and a living. The fish populations in the two marine provinces are at different levels because of their very different topographies. Fisheries make a minimal contribution to the national GDP (0.32%), and their contribution to Pakistan's agricultural GDP is 1.4%, whereas 0.01% of employment is derived from fisheries. Fish production reached 800,000 metric tonnes in 2022, with varying production from marine waters. Just 25% of the country's total fishery production was exported, with 496 million US dollars. The stagnant trend in fish production, especially in Sindh province, indicates that fish stocks are being overfished. The Government of Pakistan's Marine Fisheries Department and the FAO worked together from 2009 to 2015 to conduct a number of fish stock assessment surveys. The final evaluation report states that large fishing fleets and current fishing practices amount to "fishing for catastrophe," with the principal fish populations in Pakistani seas being overfished and decimated by 60-90 percent. Prominent ecological changes include the decrease of large-bodied, slowly growing, highly valuable predatory species; an increase in short-lived, fast-growing, small-sized species with low commercial value; a wide variety of cephalopods, mainly squids and cuttlefish (an opportunistic, fast-growing group); and an abundance of jellyfish, which further disrupts resources severely. The fishing fleet's overcapacity, harmful fishing gear, inadequate storage on fishing vessels, lack of cool chain maintenance, inadequate landing place infrastructure, and destruction of mangroves are some of the major problems facing marine fisheries. Along the Karachi shore, the primary effects of pollution are habitat loss, eutrophication in some areas due to deteriorating water quality, hazardousness to aquatic life, particularly to the commercial species’ larval stages, suffocation of intertidal marine vegetation and animals, sub-lethal effects on development and reproduction, red tides, pathogen-contaminated fish and shellfish, and the bioaccumulation of hazardous substances, especially heavy metals. Ultimately, these factors lead to the nearshore ecosystem depleting its marine life resources.
Bone health in patients with inflammatory bowel disease
Authors: Kreienbuehl Andrea , Rogler Gerhard , Emanuel Burri , Biedermann Luc , Meier Christian , Juillerat Pascal , Restellini Sophie , Hruz Peter , Vavricka Stefan R. , Aeberli Daniel , Seibold Frank
Published: June 2024

Patients with inflammatory bowel disease (IBD) are prone to reduced bone mineral density and elevated overall fracture risk. Osteopenia affects up to 40% of patients with IBD (high regional variability). Besides disease activity, IBD specialists must consider possible side effects of medication and the presence of associated diseases and extraintestinal manifestations. Osteopenia and osteoporosis remain frequent problems in patients with IBD and are often underestimated because of widely differing screening and treatment practices.
Malnutrition, chronic intestinal inflammation and corticosteroid intake are the major pathophysiological factors contributing to osteoporosis. Patients with IBD are screened for osteoporosis using dual-energy X-ray absorptiometry (DXA), which is recommended for all patients with a prolonged disease course of more than three months, with repeated corticosteroid administration, aged >40 years with a high FRAX risk score or aged <40 years with multiple risk factors. From a therapeutic perspective, besides good disease control, vitamin D supplementation and glucocorticoid sparing, several specific osteological options are available: bisphosphonates, receptor activator of nuclear factor kappa-B ligand (RANKL) inhibitors (denosumab), parathyroid hormone (PTH) analogues and selective estrogen receptor modulators.
This review provides an overview of the pathophysiology, diagnosis, prevention and treatment of IBD-associated bone loss.
ESA-China Relations in Space: An Archival Analysis of the Cooperation on the ERS Data
Authors: SAVINA Tonio
Published: June 2024

Drawing on the European Space Agency (ESA) documents held at the Historical Archives of the European Union (HAEU), the present paper tries to shed some light on ESA-China relations during the Nineties, specifically focusing on first contacts in the domain of Earth Observation through the dissemination in the People’s Republic of China (PRC) of ESA’s Earth Remote Sensing (ERS) data. First, it briefly introduces the ERS programme and the reasons behind the Chinese interest in accessing its data. Then, it analyses the process of negotiations that led Beijing to the signing of two agreements for receiving ERS data and the difficulties encountered during the scientific data application projects, especially concerning the reception, processing and timely delivery of appropriate data from the Beijing Remote Sensing Ground Station to the project teams. Finally, the legacy this cooperation has had for the future of ESA-China relations is also highlighted.