bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and Characterization of Some Complexes of Nickel(II), Copper (II), and Zinc (II) With Decylxanthate and their Adducts with Nitrogen Base Ligands, and their Biological Activity
Authors: AMEEN Mahameed , AHMED Fadia
Published: November 2023

This research includes the synthesis and characterization of twelve new complexes of mono nuclear xanthate for a number of transition metal ions Ni(II), Cu(II), and Zn(II) and through the interaction with ligand (potassium decyl xanthate) and complexes of formula [M(DEXANT)2] were prepared: M= Ni(II), Cu(II), and Zn(II), and then the interaction of these complexes with Lewis bidentate bases, to give complexes with the formula [M(DEXANT)2.L], where L= 1,10-phenanthroline, 8-hydroxyquinoline, and 2,2-bipyridine. The prepared complexes were characterized by melting point, atomic absorption spectrometry, micro elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, molar electrical conductivity, electronic absorption spectra, and magnetic susceptibility measurements. Magnetic moment and electronic spectra indicated that the complexes of type [M(DEXANT)2] had a tetrahedral geometry, while complexes of type [M(DEXANT)2.L] had an octahedral geometry. The conductivity measurements proved the non-electrolytic behavior of all compounds. The biological evaluation against bacterial species indicated that the xanthate complexes were effective against all bacterial types.
How Do Recreation Therapists Support People Living with Acquired Brain Injuries Across the Continuum of Care?: A Scoping Review and Narrative Synthesis
Authors: Ausman Christine , Neyedli Heather F. , Briere Marie-Michèle , Stebbe Courtney , Moore Sarah A.
Published: November 2023

Acquired Brain Injuries (ABIs) affect a significant number of individuals in Canada each year, leading to various functional challenges and complex care needs. Interdisciplinary teams play a crucial role in addressing these challenges, with Recreation Therapy (RecT) emerging as a valuable addition to such teams. RecT focuses on using leisure, recreation, and play as tools to enhance the independence and quality of life of individuals with ABIs. Despite its potential benefits, there is limited academic literature on the specific role of RecT in ABI care. This scoping review follows the Joanna Briggs Institute methodology and PRISMA-ScR guidelines. Inclusion criteria encompassed a broad range of ABI patients, RecT concepts, care settings, and study designs. A comprehensive search strategy was applied to multiple databases, and data extraction and analysis followed a systematic approach. A total of 71 articles were included in the review, following a rigorous screening process. These articles were diverse in terms of study design, population served, and healthcare context. Data extraction focused on the role of RecT, assessments, interventions, and patient outcomes, categorized by the dimensions of health and well-being (SPECS – Social, Physical, Emotional, Cognitive, Spiritual). A narrative synthesis approach was employed to identify patterns and themes across the included studies. This scoping review provides a comprehensive overview of the existing literature on the role of RecT in the care of individuals with ABIs. It highlights the need for more explicit recognition of RecT contributions within interdisciplinary teams and the importance of further research to establish evidence-based practices. Understanding the impact of RecT on the health and well-being of ABI patients is crucial for optimizing their rehabilitation and quality of life.
Comparison Between Maslow’s Hierarchy of Needs and the Leisure Ability Model: Theory to Practice
Authors: Ervin Amanda , Litchke Lyn G.
Published: November 2023

This practice perspective looks at the connection between the Leisure Ability Model with an addition of a proposed category of spirituality and service to others (LAM-SS) and a lesser-known version of Maslow’s New Hierarchy of Needs-6th Level Approach that adds self-transcendence (MHN-6). Further, we draw parallels between MHN-6 and LAM-SS and illustrate the relationship with a sample application of this method for Therapeutic Recreation (TR) service delivery. Both MHN-6 and LAM-SS ascribe to the movement of an individual towards the intrinsic motivation that TRs can guide as part of treatment for patients and clients in our care. These findings may serve as a guide for TR practitioners to apply in their practice, facilitating both client and practitioner’s spiritual needs.
Death Anxiety in Psychopathology: A Systematic Review
Authors: GÜRBÜZ Ayça , YORULMAZ Orçun
Published: November 2023

Death anxiety has been proposed to be a transdiagnostic construct underlying the development and maintenance of numerous psychopathological conditions. The relationship between death anxiety and mental disorders has been largely studied in specific disorders. On the other hand, it has been suggested that interventions to transdiagnostic components such as death anxiety have the potential to increase therapy efficacy for many psychological disorders. Accordingly, the aim of the study was to identify studies examined relationships between death anxiety and various mental disorders and outline measurement methods for evaluating death anxiety. Of the 933 references identified at Web of Science, Google Scholar, PubMed and APA databases, 17 articles met inclusion criteria. In the studies, the relationship between death anxiety and psychopathology and the measurement tools used to evaluate death anxiety were examined. Studies included in this review have examined the role of death anxiety in various psychological disorders including obsessive-compulsive disorder, health anxiety, social anxiety, depression, schizophrenia, generalized anxiety disorder and panic disorder. Overall, results suggested that there is a clear association between death anxiety and psychopathology, symptom severity, number of psychiatric medications and hospitalizations, depression and anxiety. Furthermore, Templer’s Death Anxiety Scale was most widely used scale for measuring death anxiety. The findings indicate that death anxiety may be an important risk factor in the development or maintaining of many psychological disorders and it is significant to include death anxiety in the treatment of mental disorders in which death anxiety may play a role.
GLOBALIZATION, REFORMS, AND EDUCATIONAL POLICIES IN LATIN AMERICA
Authors: Cifuentes Medina José Eriberto , Gonzalez Pulido José Weymar , López Valiente Erika Johana
Published: November 2023

The goal of this dissertation is to expose the impact that educational reforms have had from an administrative and academic perspective, thus permeating the idea of education quality at the different educational levels. The analysis begins by providing a general description, and then, it delves into examples from several Latin American countries. In doing so, a convenient path is paved in which all possible routes regarding public policies in education and politics could be discussed in the study. Within research lies the direction and relationship that globalization has had on educational reforms in Latin America, commencing with a state-of-the-art vision and backed up by documentary evidence. Latin America’s educational reforms are directly and proportionally related to the regional and national history of each country. Therefore, we seek to derive an interpretation based on political and economic influences since education is not independent, and its reforms are not innate from its dynamics. In general terms, educational reforms are considered no autonomous in their essence, as they rarely originate from educators and pedagogues. On the contrary, they are proposed by politicians, economists, and professionals from other areas distant to pedagogy. They are left at the mercy of economic resources, which have little to no interest in the progress and the advancement of education, in accordance with educators and those in the process of formation. The aim is to provide advancements in the hermeneutic logic of educational policies and their subsequent reforms. This is due to the interests of several people who have included reforms and policies in their governmental plans. Their objective to offer unwarranted coverage at any price is a nefarious issue that places the actors of education at a disadvantage within a cost-benefit relationship. In the search for coverage and tuition fees, the quality and relevance of education in the general and particular framework are usually neglected.
Google translate in academic writing class: How EFL learners use and perceive it
Authors: Setiamunadi Antonina Anggraini
Published: November 2023

The study of the use of Google Translate (GT) in ELT classroom has been an interesting issue to be discussed. Researchers noted that GT’s translation quality has significantly increased as a result of utilizing an Artificial Intelligence (AI) technique which studies languages through examples. The employment of GT as a tool to help students in ELT classes seems to be advantageous for them. However, many language teachers continue to question the value of this translation machine. This study investigates the learners’ perspectives towards the use of GT in their Academic Writing class; whether they think it is helpful in assisting them in the learning process or not. The researchers attempt to answer the research question of “What are the learners’ perceptions towards the use of GT as a learning support in Academic Writing class?” because there are still very few studies that have examined the use of GT as a learning support tool in Academic Writing class. The study uses a qualitative approach through the use of interviews as a data collection instrument. The interviews were conducted with five participants from the English Language Education program of the Faculty of Language and Arts in one private university in Central Java. The participants are the students who have just taken Academic Writing (AW) class in the previous semester before the research was conducted. The findings of the study show that all participants agree that GT has its own positive and negative impacts in their learning in the classroom.
A Profile of Primary School Students’ Literacy Through EMI in CLIL Contexts
Authors: Rachmajanti Sri , Anugerahwati Mirjam , Unsiah Frida
Published: November 2023

For several years, the competence of students in Indonesia has always been recorded as very low. In PISA, Indonesia ranks at the 3rd or 4th lowest position, especially in Reading, Mathematics, and Science. This condition has, of course, raised the concerns of educators in Indonesia, and some schools then decided to implement an international curriculum along with the 2013 Curriculum. With the international curriculum, students are required to have very good literacy, to comprehend the texts and questions they work on. This also entails teaching them with teaching strategies which, besides developing their language competence, also enhance their critical thinking skills. This paper reports some ways in which EMI and CLIL can develop primary school students’ English proficiency, literacy, and critical thinking skills. Data were taken from some Primary Schools which implement the synergy of national and international standard curricula, particularly from the scores of the students on two tests. Focus is given to the students’ English proficiency and literacy.
Analysis of the Oil Distribution and Flooding Characteristics of Shale Oil Reservoirs Using NMR and Microfluidic Experiments
Authors: Fuwei Yu , Mingyue Cui , Xin Chang , Fei Xu , Hanqiao Jiang , Junjian Li
Published: November 2023

The Gulong shale oil reservoir in the Daqing Oilfield of China is characterized by well-developed fracture bedding planes. Studying the distribution and evolution of Gulong shale oil, specifically the size of oil-bearing pores, the content of oil in organic and inorganic pores, and the evolution of oil distribution during gas displacement, can aid in the development of shale oil. To this end, this study employed T1-T2 NMR spectra for the aforementioned investigations. A Gulong shale core is tested in this experiment. NMR T1-T2 and T2 spectral scans are conducted on the cores in both before and after it saturated with oil. Then gas displacement experiments are conducted, and NMR scans are taken. The oil distributions in the organic and inorganic pores are characterized using the T1-T2 spectra. The evolution of oil distribution under gas displacement in the shale cores is characterized by NMR T2 spectra. The T1-T2 spectra results revealed that the oil in both organic and inorganic pores was distributed in two distinct regions with different T2 value intervals. The oil in the organic pores consisted of residual heavy oil components and saturated oil, and they were distributed in a small T2 value interval and different T1/T2 value interval. On the other hand, the oil in the inorganic pores was primarily composed of saturated oil. Mobile oil was observed in the inorganic pores and was distributed in the largest T2 value interval among all oil phases. Additionally, the T2 spectra further revealed the displacement efficiency of different pores in shale core. Furthermore, Micromodel flooding and imbibition experiments have been conducted to study the flow dynamics of water in porous, which demonstrated the high recovery of water flooding for nanopores in shale oil reservoirs.
Enhanced Efficiency of Rna-guided Cas12a Versus Cas9 Transgene Knock-in and Activity at a Schistosoma Mansoni Genome Safe Harbor
Authors: Ittiprasert Wannaporn , Moescheid Max , Wisitphongpun Prapakorn , Mann Victoria , Quack Thormas , Grevelding Christoph , Grunau Christoph , Brindley Paul
Published: November 2023

Recently, we reported programmed Cas9 mediated insertion of a reporter gene into a gene safe harbor site, GSH1, of Schistosoma mansoni via homology-directed repair (HDR) using overlapping guide RNAs. Here, we report efficient and precise CRISPR/Cas12a-mediated homology directed insertion (knockin, KI) of a 5’ C6-PEG10-modified double-stranded transgene bearing microhomology arms, 50 nt in length, at GSH1. At the outset, we undertook bioinformatic and computational analysis following by experimental verification of the regulatory activity of endogenous schistosome ubiquitin (SmUbi) promoter and terminator, to drive strong reporter gene expression. Green fluorescent protein activity driven by SmUbi followed electroporation-mediated transfection of schistosome eggs. HDR induced by RNA-guided CRISPR/Cas12a, which releases overhanging DNA strands of 18-24, delivered more efficient KI than CRISPR/Cas9. In this non-model pathogen, programmed KI facilitated precise chromosomal integration of the reporter-gene with at GSH1. The approach advances schistosome transgenesis field and may also advance functional genomics and transfection methods in related parasitic and non-parasitic helminths, which hitherto lack these tools.
Introduction to a novel gamma radiation shield utilizing polyurethane-PbO nanocomposite
Authors: dorostkar mahdieh , Kangarlou Haleh , Saray Akbar Abdi
Published: November 2023

The importance of searching for proper material against radiation hazard has been studied since the beginning of radiation perusal and understanding the fact of radiation protection. Gamma radiation protection materials usually deal with heavy elements with higher price, hard to maintain and etc. Polyurethane based materials are one the popular choices nowadays in sound and thermal insulation, their low weight properties and the most important, their fast and convenient construction ingredients; however, PU foams can be used as radiation shield as well as noise and heat resistance; due to their approachability, light weight, high resistance, comfortable construction and etc. This study is an effort in both simulation and experiment to construct and investigate the properties of Polyurethane material dopped with lead oxide, as gamma shield. The shield was considered in several weight fractions of lead and led to several samples. MCNPX 2.6 Monte Carlo code has been utilized for simulation procedure and 137Cs has been used as gamma source in both simulation and experiment. The results have a promising response against the gamma radiation and are suitable in attenuating gamma rays.
Targeted metabolomics reveals plasma short-chain fatty acids are associated with metabolic dysfunction-associated steatotic liver disease
Authors: Thing Mira , Werge Mikkel Parsberg , Kimer Nina , Hetland Liv , Rashu Elias , Nabilou Puria , Junker Anders , Galsgaard Elisabeth Douglas , Bendtsen Flemming , Laupsa-Borge Johnny , McCann Adrian , Gluud Lise Lotte
Published: November 2023

Background
Alterations in the production of short-chain fatty acids (SCFAs) may reflect disturbances in the gut microbiota and have been linked to metabolic dysfunction-associated steatotic liver disease (MASLD). We assessed plasma SCFAs in patients with MASLD and healthy controls.
Methods
Fasting venous blood samples were collected and eight SCFAs were measured using chromatography-tandem mass spectrometry (GC-MS/MS). Relative between-group differences in circulating SCFA concentrations were estimated by linear regression, and the relation between SCFA concentrations, MASLD, and fibrosis severity was investigated using logistic regression.
Results
The study includes 100 patients with MASLD (51 with type 2 diabetes, 51 with mild/no fibrosis, and 49 with significant fibrosis) and 50 healthy controls. Compared with healthy controls, MASLD patients had higher plasma concentrations of propionate (21.8%, 95% CI 3.33 to 43.6, p = 0.02), formate (21.9%, 95% CI 6.99 to 38.9, p = 0.003), valerate (35.7%, 95% CI 4.53 to 76.2, p = 0.02), and α-methylbutyrate (16.2%, 95% CI 3.66 to 30.3, p = 0.01) but lower plasma acetate concentrations (− 30.0%, 95% CI − 40.4 to − 17.9, p < 0.001). Among patients with MASLD, significant fibrosis was positively associated with propionate (p = 0.02), butyrate (p = 0.03), valerate (p = 0.03), and α-methylbutyrate (p = 0.02). Six of eight SCFAs were significantly increased in F4 fibrosis.
Conclusions
In the present study, SCFAs were associated with MASLD and fibrosis severity, but further research is needed to elucidate the potential mechanisms underlying our observations and to assess the possible benefit of therapies modulating gut microbiota.
Substantiation of the coefficients of joint operation of a diesel engine and hydromechanical transmission of a wheeled skidder
Authors: Кочнев А.М. , Кривоногова А.С. , Пушков Ю.Л.
Published: November 2023

Многочисленные исследования в различных лесопромышленных регионах РФ и климатических условиях позволили сформулировать научное положение, которое утверждает, что при трелевке пачки древесины в различных почвенно-грунтовых и климатических условиях коэффициенты загрузки двигателя по оборотам (KЗ), крутящему моменту (Kn) и мощности (KN) достаточно стабильны. Стабильность значений коэффициентов KЗ, Kn, KN при трелевке пачки древесины на конкретной передаче в различных производственных условиях принята за базу при прогнозировании эксплуатационных, нагрузочных и расчетных режимов и в создании теории эксплуатационной эффективности работы трелевочных тракторов. Предложена методика определения коэффициентов совместной работы двигателя с гидромеханической трансмиссией, значения которых являются базисом прогнозирования эксплуатационных режимов и эксплуатационной эффективности работы колесных трелевочных тракторов.При разработке новых или усовершенствовании серийных трелевочных тракторов необходимо иметь представление о влиянии параметров и технических решений, применяемых в механизмах, системах и узлах на рабочие режимы машины, которые определяют нагруженность элементов конструкций, а, следовательно, ее надежность и технико-эксплуатационные показатели, в том числе и влияющие на эксплуатационную эффективность работы.

Numerous studies in various timber industry regions of the Russian Federation and climatic conditions have made it possible to formulate a scientific position, which states that when skidding a pack of wood in various soil-soil and climatic conditions, the engine load coefficients in terms of speed ( Ks ), torque ( Kt ) and power ( KN ) are quite stable. The stability of the values of the coefficients K З, Kn , K З when skidding a pack of wood in a specific gear in various production conditions is taken as the basis for predicting operational, load and design modes and in creating a theory of operational efficiency of skidders. A method for determining the coefficients of joint operation of the engine with a hydromechanical transmission is proposed, the values of which are the basis for predicting the operating conditions and operational efficiency of wheeled skidders. When developing new or improving serial skidders, it is necessary to have an idea of the influence of parameters and technical solutions used in mechanisms, systems and assemblies on the operating modes of the machine, which determine the load of structural elements, and, consequently, its reliability and technical and operational indicators, including those affecting the operational efficiency of work.
Impact of cattle grazing on forest regeneration processes in the Novosibirsk Region
Authors: Кузин Д.Е. , Данилов Д.А.
Published: November 2023

Целью исследования было определить особенности лесообразовательного процесса под воздействием выпаса крупного рогатого скота, на землях сельскохозяйственного назначения, вышедших из активного оборота в условиях Западной Сибири. Исследование проводилось на бывших пашнях, использовавшихся под выпас и находящихся на разных стадиях лесовосстановительного процесса. Проведена комплексная оценка и анализ биометрических показателей древостоя, живого напочвенного покрова, почв, что позволяет определить особенности генезиса формируемых фитоценозов и спрогнозировать динамику их развития в условиях Новосибирской области. На основании проведённого исследования сформирована гипотеза об эндозоогенном характере распространения сосны обыкновенной на пастбищах в лесостепной зоне.

The aim of the study was to determine the characteristics of the forest formation process under the influence of cattle grazing on abandoned agricultural lands in the conditions of Western Siberia. The study was conducted on former cropland used for grazing and at different stages of the reforestation process. A comprehensive assessment and analysis of the biometric indicators of the stand, ground cover, and soil was carried out, which allows us to determine the genesis of the emerging phytocenosis and predict the dynamics of their development in the Novosibirsk region. Based on the study the hypothesis of the endozoogenic nature of the distribution of Scots pine in pastures in the forest-steppe zone was formed.
Review of schemes for transport-geographical zoning of the Arctic water area
Authors: Kidzhi D. S.
Published: November 2023

The retrospective and modern schemes for geographic and transport zoning of the Arctic and the Northern Sea Route are examined. The historical research method, which consists in identifying and analyzing documented facts, historical processes and their logic in terms of clarifying development, is used. There are several stages in the formation of zones and areas in the waters of the Arctic seas. The time period chosen for the review is from the beginning of the 19th century to the present in chronological order. International relations, national legal and natural conditions, and country characteristics are taken into account. The evolution of the organizational structure for managing the operation of the transport system of the Northern Sea Route, from the creation of the first administration to the present day, is considered. The countries of the Arctic Council have not yet developed a uniform approach to such tasks as the classification of ice (ice conditions) and requirements for the design of a vessel (ship ice class). Most countries use the definitions from the Polar Code. Individual countries apply their own rules and classification. The Russian Federation, for example, when choosing criteria for the admission of ships, uses both the national classification (Arc4-Arc9) and the Baltic one (Ice1-Ice3), while recognizing the ice classes of ships according to the International Association of Classification Societies. The results of a comparison of the Arctic Council countries on the presence of signs for development of transport-geographical zoning and navigation management in the Polar waters are presented. In conclusion, a list of tasks, the solution of which will contribute to the future transition from geographical to transport zoning of the Northern Sea Route and the Polar waters as a whole, is provided.
Features of hydrodynamic calculation of highly loaded plain bearings of heavy ship’s gears
Authors: Kuznetsov R. V. , Chistov V. B. , Vikhrov N. M.
Published: November 2023

Despite the high level of modern vessel engineering development, there are a number of unresolved design and technological problems, the most urgent of which is the issue of unification of the main components and assemblies of the vessel. At the same time, an important and unresolved task is to create a unified image of the ship’s reverse gear for the needs of the domestic civilian fleet and navy. The object of study is highly loaded bimetallic plain bearings, which are elements of the “heavy” marine reverse gears of a new generation. As part of the work, a hydrodynamic calculation that refines the parameters of the plain bearings of a highly loaded marine transmission at the stage of a prototype production is performed. The applicability of the State Standard ISO 7902 methodology to the products under consideration is assessed, as well as the approximation of the performance characteristics of bearings using interpolation of two variables function is performed. The rationale for the coverage angle and the location of the pockets for supplying lubrication of bearings taking into account the thermal and viscous properties of the oil is presented. Calculations of the parameters of the critical thickness of the lubricating layer, the maximum allowable specific load and the maximum allowable temperature of bearings are performed. Based on the results of the calculations, an additional assessment for the compliance of bearings with the requirements of State Standard ISO 7902 in terms of bearing capacity and stability parameters is carried out. The comparison of the obtained results with the data of the preliminary calculation performed at the stage of the technical project is given. It is revealed that when calculating dynamically loaded plain bearings, it is necessary to take into account a number of additional factors, namely the magnitude of the relative eccentricity and relative clearance. The risks of bearings failure in the process of dynamic loading are determined. The result of the work is the correction of the geometric parameters of the plain bearings of the marine reverse gear unit in order to increase its reliability and the overhaul interval.
Simulation of energy losses in an inflow turbine with partial blading of the runner
Authors: Kryukov A. A. , Kulichkov S. V. , Ratnikov A. A.
Published: November 2023

Studying the coefficients of kinetic energy losses of the nozzle diaphragm and the runner in an inflow turbine with partial blading of the runner is carried out. It is noted that inflow low-consumption turbines are reliable and productive devices designed to drive various units. Due to their compact size, they are especially in demand in various branches of mechanical engineering. However, in order to increase efficiency and reduce production costs, it is necessary to constantly improve the technology of manufacturing turbine stages. Some inflow turbines are partial, which leads to additional energy losses. Partial stages in which there are no losses from ventilation, namely, turbines with partial flapping of the runner are considered. To simulate such turbines, the ANSYS CFX software package is used in the work. By using ANSYS Design Modeler to create a geometric model and determine boundary conditions, as well as selecting the appropriate grid, the dependences of the loss coefficients in the nozzle and the runner are obtained. The study has shown that the degree of partiality and the Mach number of the turbine stage have a significant impact on the losses coefficients in the exact part of the nozzle and the runner. To account for these dependencies in the modeling process, empirical dependencies, which are an integral part of the design process of inflow turbines, are obtained. The use of the obtained empirical dependences makes it possible to more accurately predict the characteristics and performance of turbines of this type, as well as to supplement the existing mathematical model of the flow in the flow part of a low-consumption inflow turbine with partial blading of the runner.
Modal synthesis of observers of state variables of ship dynamical systems
Authors: Chertkov A. A. , Kask Ya. N. , Ivanyuk V. Yu.
Published: November 2023

The purpose of the work is to increase the information content of ship control systems through the use of dynamic observers, which are, in essence, mathematical information sensors and allow you to fully restore the vector of state variables of the object model with high accuracy by measuring the output vector of a smaller dimension. An algorithm for the synthesis of observers based on the modal method of parametric evaluation of their model is proposed. It provides obtaining the parameters of the regulator according to the given spectra of the matrices of the state of the observed system and the object by means of the Control Toolbox of the MATLAB computing environment. The use of the modal method (subject to the conditions of observability and controllability) guarantees the stability of observers, which allows them to be used for stable and unstable observed objects and systems. The algorithm of modal synthesis of observers is suitable for increasing the information content of a wide range of ship dynamic systems and, above all, control systems for ship energy complexes and their components. These include autopilots, control systems for ship power plants and their elements, dynamic complexes of satellite and inertial navigation systems and positioning of moving objects in remote control conditions, monitoring and safety tools, identifiers, etc. It has been shown that in the conditions of digital transformation, the use of observers dramatically improves the quality and reduces the time for modeling the dynamics of ship systems and energy complexes operated under conditions of external disturbances, which makes it possible to improve the algorithms for estimating state variables of a class of autonomous objects modeled by nonlinear equations that allow the transition in the working area to quasi linear models with time-invariant parameters. The proposed algorithm is demonstrated by the example of the synthesis of a three-dimensional observer for the control system of a supertanker with deadweight of 150 thousand tons. The simulation of the control object is performed with an input signal of triangular shape, which most fully corresponds to the real control signal, and it is implemented in the form of a program compiled in MATLAB codes. The obtained values of state variables and errors of their recovery correspond to the specified speed and the required stability of the control system.
A Glance on the Geopolitics from the Sustainability Prospective
Authors: COSSIGA Dr. Giovanni Antonio
Published: November 2023

Is a new globalization possible after the first one runs out? Yes, because we need to accept that the miracle of globalization in Asia, which began under the impetus of the economic opportunities of capital that moved from the West to South and South-East Asia, cannot be reproduced elsewhere. Furthermore, this great event is coming to an end, as is shown by the political tensions that have arisen between the USA and China, as well as by the weakening of the development drive in China. After more than half a century of frantic progress, a strong global engine that brought people together. This does not mean that there is not already underway - although under observation - a revival which this time concerns and will involve the old continent and Africa, not under the guise of the past but with a new identity that aims to prevent young Africa from suffer the shame of a new neo-colonization. Even in the case in question, the driving force is the hesitation due to the colonial past of many European countries and the difficulties of the black continent in dealing with the moods of the financial markets and above all speculative capital with its own forces. But the potential of the African continent is exceptional in terms of natural resources. But it is necessary to overcome the obstacle of weak or very weak public services and the degradation of youth far from schools, of the population without adequate health services, of land management for the feeding needs of a growing, very young community which in 2050 it could represent 25% of the world population. To attenuate the memory of the colonial past, it is appropriate for Europe to present itself as a Union, that is, a new entity compared to the past and which meanwhile directs the resources of capital, experience, culture and science in a unitary way to provide the capital that is necessary for finance essential public services, food, school and health issues. That is, creating the conditions for the management of investment management to be carried out by local workers and specialists. It is an opportunity to advance in the name of direct democracy. in this sense it is proposed that the communities of Europe should initiate the relationship between communities between Europe and Africa with referendums.
Implementation of Quality Management System for a Small Scale Building Construction project Sites.
Authors: Vishe Tejal
Published: November 2023

Abstract: The construction industry plays a crucial role in consistently delivering value and quality to its clients. Nevertheless, it faces challenges related to quality, leading to unsatisfactory outcomes, unsafe structures, and budget overruns. To address these issues, it is essential to establish a Quality Management System (QMS). This systematic approach ensures both product and process quality, not only satisfying customers and adhering to regulations but also reducing rework and waste. The successful implementation of a robust QMS involves tasks such as business analysis, initial planning, awareness raising, expert training, document control, deployment, measurement and control, auditing, and continuous improvement. This research focuses on the importance of quality management in small-scale construction projects during the execution phase. It involves data gathered from interviews and questionnaires with builders/contractors, consultants, and customers/building occupants. By examining the quality management practices of these small-scale building contractors and their impact on customer satisfaction, operational efficiency, and cost-effectiveness, this study aims to provide valuable insights into the matter.
Effectiveness of e-consultations in Improving Patient Outcomes through Hidoc Consult: A Pilot Study
Authors: Yadav Arina
Published: November 2023

Abstract: Patient outcomes are hugely dependent on the response and care given by clinicians. In certain areas of Western countries like the United States, Canada, and others, specialist availability becomes a challenge1 . The specialists are often overburdened with patients which eventually impacts the wait times of getting an appointment. Under such circumstances, the patient's outcomes are affected, and the longer wait times impact the patient's health. Teleconsultations or e-consultations are often referred to in such cases, a low-cost referral system can have a useful implementation1 . A pilot study was conducted aiming to understand the effectiveness of e-consultations in improving patient outcomes.
Analysis of Converter-Fed Rotor Based Induction Machine
Authors: Alam Prawej
Published: November 2023

Abstract: This paper presents the analysis of an induction-machine with a concept of the rotor-fed by a converter. Statorwinding configured in star and connected to the input-side of the three-phase voltage-source, whereas rotor-windings are fed by back-to-back converter by means of DC-link capacitor. For this, the Induction-machine is modelled in MATLAB/Simulink and simulated with and without a converter. The rotor circuit is magnetized with the help of back-to-back converter which in turns supply the variable-reactive power by setting the different phase-shift angle between the converters. The results depict the enhancement of Power-factor and also presents the dynamic performance of the machine includes the loading and de-loading as well as the starting condition of the machine. Fundamental-frequency variations of the converter enhance capability of machine to operate at a constant-speed with variable-load operation. Impact of variation in phase-shift angles between the converters on the power-factor, reactive-power, stator and rotor-current are also presented.
Novel trimeric aggregation-induced emission (AIE)-photosensitizer for long-acting imaging and hypoxia-overcoming photodynamic therapy
Authors: , Sauraj , Kang Ji Hee , Lee O Hyun , De Anindita , Ko Young Tag
Published: November 2023

The less oxygen-dependent, cellular organelle-specific photosensitizers
(PSs) with long-term in-vivo imaging and efficient reactive oxygen
species (ROS) generation capabilities are highly desirable for
imaging-guided photodynamic therapy (PDT) under hypoxia, but still
challenging. In this contribution, three mitochondria-targeting,
aggregation-induced emission (AIE)-based photosensitizers termed as
TPEPyTMB-1 (monomeric), TPEPyTMB-2 (dimeric) and TPEPyTMB-3 (trimeric)
were synthesized to enhance the AIE-effect, ROS generation, and
mitochondria-targeting ability. The rationally synthesized AIE-PSs
efficiently produce a mixture of type-1 and type-2 ROS with excellent
photophysical properties in terms of near-infrared (NIR) emission, large
Stock-shift (> 225 nm) and high photostability. The
biocompatible AIE-PSs nanoparticles (AIE-PSs NPs) were fabricated using
an amphiphilic block copolymer (DSPE-PEG). Among them, TPEPyTMB-3 NPs
with superior intracellular ROS production efficiency as well as greater
mitochondria-targeting capabilities, demonstrated efficient PDT efficacy
in both normoxia and hypoxia environments. In-vivo results revealed that
TPEPyTMB-3 NPs can effectively inhibit the growth of subcutaneous
tumors, under white light irradiation with minimized systemic toxicity.
Moreover, TPEPyTMB-3 NPs accumulated at tumor sites and displayed
outstanding long-term in-vivo imaging capability (up to 7 days). This
study provides a new perspective for developing the emerging AIE-PSs to
maximize PDT performance through the trimerization of small
AIE-photosensitizer.
“Matthew Effect”: General Design Strategy of Fluorogenic Bioorthogonal Nanoprobes with Ultrahigh Emission Enhancement
Authors: Segawa Shinsuke , OU Xinwen , Shen Tianruo , Ryu Tomohiro , Ishii Yuki , Sung Herman , Williams Ian , Kwok Ryan T. K. , Miyata Kiyoshi , Onda Ken , He Xuewen , Liu Xiaogang , Tang Ben
Published: November 2023

Fluorescence imaging, a key technique in life science research,
frequently utilizes fluorogenic probes for precise imaging in living
systems. Tetrazine is an effective emission quencher in the design of
fluorogenic probes, which can be selectively damaged upon bioorthogonal
click reactions, leading to considerable emission enhancement. Despite
significant efforts to increase the emission enhancement ratio upon
click reaction (I/I)
of tetrazine-functionalized fluorogenic probes, the influence of
molecular aggregation on the emission properties has been largely
overlooked in the design of these probes. In this study, we reveal that
an ultrahigh I/I can
be realized in the aggregate system when tetrazine is paired with
aggregation-induced emission (AIE) luminogens. Tetrazine can increase
its quenching efficiency upon aggregation and drastically reduce
background emissions. Subsequent click reactions damage tetrazine and
trigger significant AIE, leading to considerably enhanced
I/I. We further
showcase the capability of these ultra-fluorogenic systems in selective
imaging of multiple organelles in living cells. We propose the term
“Matthew Effect” in Aggregate Emission to describe the unique
fluorogenicity of these probes, potentially providing a universal
approach to attain ultrahigh emission enhancements in diverse
fluorogenic aggregate systems.
Biomarkers to predict changes in peanut allergy in children over time
Authors: Foong Ru-Xin , Toit George Du , Ree Ronald Van , H Tee Bahnson , Radulovic Suzana , Craven Jo , Kwok Matthew , Jama Zainab , S.A. Versteeg , Brough Helen A. , Logan Kirsty , Perkin Michael , Flohr Carsten , Lack Gideon , Santos Alexandra
Published: November 2023

Background: Various biomarkers are used to define peanut
allergy (PA). We aimed to observe changes in PA resolution and
persistence over time comparing biomarkers in PA and peanut sensitised
but tolerant (PS) children in a population-based cohort.
Methods: Participants were recruited from the EAT and EAT-On
studies, conducted across England and Wales and were generally well
exclusively breastfed babies recruited at 3 months old and followed up
until 11 years old. Clinical characteristics, skin prick test (SPT),
sIgE to peanut and peanut components and mast cell activation tests
(MAT) were assessed at 12m, 36m and 7-11y. Results: The
prevalence of PA was 2.1% with only 1 child having PA resolution at
7-11y. PA children had larger SPT size, higher peanut-sIgE, Ara h 2-sIgE
and MAT (all p<0.001) compared to PS children at 36m and
7-11y. SPT, peanut-sIgE, Ara h 2-sIgE and MAT between children with
persistent PA, new PA, outgrown PA and PS were statistically significant
at both 36m and 7-11y (p<0.001). Those with persistent PA had
SPT, peanut-sIgE and Ara h 2-sIgE that increased over time and MAT which
was highest at 36m. New PA children had increased SPT and peanut-sIgE
from 36m to 7-11y, but MAT remained low. PS children had low biomarkers
across time. Conclusions: In this cohort, few children outgrow
or develop new PA between 36m and 7-11y. Children with PA have
significantly higher SPT, peanut-sIgE, Ara h 2-sIgE and MAT compared to
PS children, evident from 12-36m of age.
A Clinical Psychological Analysis of Virtual Care Adoption During the COVID-19 Pandemic: Digital Resilience in Pain Management
Authors: Brass Justin , Lau Brenda , Abreu Emmanuel , Singh Neha , Venkataraman Tameus , McParland Aidan , Xin Kai , Sluka Dorina
Published: November 2023

The COVID-19 pandemic has necessitated a rapid transformation in
healthcare delivery, prompting a shift from traditional in-person
services to digital platforms. This comprehensive review explores the
transition of the clinic, a community-based pain clinic, to online
services, examining the challenges, benefits, and implications for
patient care and accessibility. This paper delves into the experiences
of patients and providers, highlighting the role of digital health in
improving accessibility and overcoming geographical barriers. The paper
also addresses the behavioural changes required for effective online
interactions and the importance of setting clear expectations to support
virtual modalities for pain care. Through a qualitative analysis, key
themes and insights are identified, providing a nuanced understanding of
the impact of digital transformation on pain management services to
create an evidence-based discussion.
Immune cell and immune related molecular for GC risk: A study combining the transcriptome and Mendelian randomization
Authors: Chen Shuran , yin jiabao , li pengcheng , tong zhong
Published: November 2023

Background: Gastric cancer(GC) is a common and poor prognosis malignant
solid tumour, the application of immunotherapy has improved the
prognosis of patients greatly, but the precise immunotherapy strategy is
still the difficult problem of immunotherapy. Mendel randomization is a
way to demonstrate exposure and outcomes at a causal level. Mendel
randomization trial is therefore an excellent way of looking at the
causal link between immune cells and the risk of GC, with the aim of
providing new insights into immunotherapy regimens for GC patients.
Method: Genetic instrumental variables(IVs) for GC were obtained from a
genome wide association study (GWAS). Inverse-variance weighted (IVW)
method was used as the primary analysis. Simple-median method,
weighted-median method, MR-Egger regression, and MR pleiotropy residual
sum and outlier test were used as the further analysis. Uni-cox and
lasso were used to select genes related to GC and survival model was
constructed. Through many data of GC patients, we further explored the
relationship between risk models and prognosis of GC patients,
association between tumour mutation load(TMB) and microsatellite
instability state(MSI). Result: We obtained 731 immune cells from
previous studies. From these cells, we screened six immune cells closely
associated with GC. Based on the SNPs of 6 immune cells, we obtained 77
genes. After Cox and lasso analysis, we obtained 5 immune cell related
genes. The 5-gene risk model can divide patients into two GC groups with
different prognosis. High risk GC patients had higher suppressive immune
cell infiltration, lower TMB, lower tumour cell stemness, and higher
TIDE scores. Conclusion: This study based on a variety of data from MR
analysis demonstrated the association between immune cells and GC risk
at the causal level. 6 immune cell-related genes are associated with
TMB, MSI and immunotherapy sensitivity in GC patients.
Miniaturized gas exposure devices for atom probe experiments
Authors: Ott Benedict , Heller Martina , Monajem Mehrpad , Felfer Peter
Published: November 2023

To detect hydrogen in materials at the atomic scale, atom probe
tomography is now regularly used. In order to avoid cumbersome
cryo-preparation to suppress diffusion, often hydrogen is charged only
into the finished specimen. Here, the use of hydrogen gas over
electrochemical hydrogen has the advantage that the specimen is not
contaminated with an electrolyte. So far, this ‘charging’ has been done
in large, expensive systems. Here, we introduce small devices that
enable the exposure of atom probe specimens to hydrogen and potentially
other gases, using only very small gas volumes. This enables the
operation in regular laboratory environments without additional safety
measures. These devices can be used to expose the specimen to hydrogen
up to 10 bar / 90 °C. Higher temperatures may be attained with small
changes. Validation of the success of charging with these setups is
demonstrated through experiments employing deuterium charging of
palladium atom probe tips.