bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Highly Selective and Stable Co-Cr/SAPO-34 Catalyst for the Catalytic Dehydration of Ethanol to Ethylene
Authors: Niu Peirong , Ren Xiao , Xiong Deyuan , Ding Shilei , Li Yuanlin , Wei Zhaozhou , Chen Xusong
Published: July 2020

In this study, silicoaluminophosphate (SAPO)-34 and Me (Me = Cr, Co)-modified SAPO-34 were synthesized and used as catalysts to investigate the catalytic performance by means of a probe reaction from ethanol to ethylene. The metal oxides were loaded on the SAPO-34 support via an impregnation method. The synthesized catalysts were characterized using XRD, SEM, EDX, FT-IR, NH3-TPD, BET, and TGA techniques. Compared to SAPO-34, SAPO-34 doped with metal oxides showed the same chabazite (CHA) topology. The structure and properties of the catalyst were further optimized by varying the amount of Me. The experimental results showed that Co-Cr/SAPO-34 exhibited the best catalytic performance when the reaction temperature reached 400 °C at a weight hourly space velocity (WHSV) of 3.5 h−1, for which the single-pass conversion of ethanol was determined as 99.15%, and the selectivity of ethylene was 99.4% at an optimum catalytic performance in the reaction of up to 600 min. In addition, Co-Cr/SAPO-34 exhibited better catalytic activity and anti-coking ability than pure SAPO-34, which was attributed to its enhanced pore structure and moderate acidity. It can also be concluded from the results of this experiment that the performance of the Co-Cr bimetal-supported catalyst is better than that of the Cr mono-metal catalyst.
Inhibition of NF-κB Signaling Alters Acute Myelogenous Leukemia Cell Transcriptomics
Authors: Reikvam Håkon
Published: July 2020

Acute myelogenous leukemia (AML) is an aggressive hematological malignancy. The pathophysiology of the disease depends on cytogenetic abnormalities, gene mutations, aberrant gene expressions, and altered epigenetic regulation. Although new pharmacological agents have emerged during the last years, the prognosis is still dismal and new therapeutic strategies are needed. The transcription factor nuclear factor-κB (NF-κB) is regarded a possible therapeutic target. In this study, we investigated the alterations in the global gene expression profile (GEP) in primary AML cells derived from 16 consecutive patients after exposure to the NF-κB inhibitor BMS-345541. We identified a profound and highly discriminative transcriptomic profile associated with NF-κB inhibition. Bioinformatical analyses identified cytokine/interleukin signaling, metabolic regulation, and nucleic acid binding/transcription among the major biological functions influenced by NF-κB inhibition. Furthermore, several key genes involved in leukemogenesis, among them RUNX1 and CEBPA, in addition to NFKB1 itself, were influenced by NF-κB inhibition. Finally, we identified a significant impact of NF-κB inhibition on the expression of genes included in a leukemic stem cell (LSC) signature, indicating possible targeting of LSCs. We conclude that NF-κB inhibition significantly altered the expression of genes central to the leukemic process.
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Authors: Yadati Tulasi , Houben Tom , Bitorina Albert , Shiri-Sverdlov Ronit
Published: July 2020

Cathepsins are the most abundant lysosomal proteases that are mainly found in acidicendo/lysosomal compartments where they play a vital role in intracellular protein degradation,energy metabolism, and immune responses among a host of other functions. The discovery thatcathepsins are secreted and remain functionally active outside of the lysosome has caused a paradigmshift. Contemporary research has unraveled many versatile functions of cathepsins in extralysosomallocations including cytosol and extracellular space. Nevertheless, extracellular cathepsins are majorlyupregulated in pathological states and are implicated in a wide range of diseases including cancerand cardiovascular diseases. Taking advantage of the dierential expression of the cathepsinsduring pathological conditions, much research is focused on using cathepsins as diagnostic markersand therapeutic targets. A tailored therapeutic approach using selective cathepsin inhibitors isconstantly emerging to be safe and ecient. Moreover, recent development of proteomic-basedapproaches for the identification of novel physiological substrates oers a major opportunity tounderstand the mechanism of cathepsin action. In this review, we summarize the available evidenceregarding the role of cathepsins in health and disease, discuss their potential as biomarkers ofdisease progression, and shed light on the potential of extracellular cathepsin inhibitors as safetherapeutic tools.
Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4
Authors: Ichise Yoshihide , Saegusa Jun , Tanaka-Natsui Shino , Naka Ikuko , Hayashi Shinya , Kuroda Ryosuke , Morinobu Akio
Published: July 2020

Objectives: Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). Methods: The induction of pro-inflammatory cytokines, chemokines, and mediators by sCD14 stimulation of RA-FLS was quantified by real-time PCR and ELISA. Cell proliferation was assessed by the BrdU assay. LPS-RS, a Toll-like receptor 4 (TLR-4) antagonist, was used to block TLR-4 signaling. Results: Soluble CD14 induced the expression of IL-6 mRNA and secretion of the protein. The expression of other pro-inflammatory cytokines and mediators, such as TNF-α, IL-8, intercellular adhesion molecule-1 (ICAM-1), MMP-3, and RANK ligand (RANKL), was also induced by sCD14. In addition, sCD14 stimulation promoted RA-FLS proliferation. LPS-RS abolished IL-6, IL-8, and ICAM-1 mRNA induction by sCD14 in RA-FLS. On the other hand, TNF-α and IL-17A increased TLR-4 expression by RA-FLS and amplified their sCD14-induced IL-6 expression. Conclusions: Soluble CD14 transmits inflammatory signals to RA-FLS via TLR-4. The effects of sCD14 may be augmented in inflammatory milieu. Our results suggest that sCD14 is involved in the pathogenesis of RA and may be a novel therapeutic target.
BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish
Authors: Carrington Blake , Weinstein Rachel N. , Sood Raman
Published: July 2020

The ease of use and robustness of genome editing by CRISPR/Cas9 has led to successful use of gene knockout zebrafish for disease modeling. However, it still remains a challenge to precisely edit the zebrafish genome to create single-nucleotide substitutions, which account for ~60% of human disease-causing mutations. Recently developed base editing nucleases provide an excellent alternate to CRISPR/Cas9-mediated homology dependent repair for generation of zebrafish with point mutations. A new set of cytosine base editors, termed BE4max and AncBE4max, demonstrated improved base editing efficiency in mammalian cells but have not been evaluated in zebrafish. Therefore, we undertook this study to evaluate their efficiency in converting C:G to T:A base pairs in zebrafish by somatic and germline analysis using highly active sgRNAs to twist and ntl genes. Our data demonstrated that these improved BE4max set of plasmids provide desired base substitutions at similar efficiency and without any indels compared to the previously reported BE3 and Target-AID plasmids in zebrafish. Our data also showed that AncBE4max produces fewer incorrect and bystander edits, suggesting that it can be further improved by codon optimization of its components for use in zebrafish.
Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells
Authors: Kim Jungmin , Cheong Jae-Ho
Published: July 2020

Despite the promise of cancer medicine, major challenges currently confronting the treatment of cancer patients include chemoresistance and recurrence. The existence of subpopulations of cancer cells, known as cancer stem cells (CSCs), contributes to the failure of cancer therapies and is associated with poor clinical outcomes. Of note, one of the recently characterized features of CSCs is augmented mitochondrial function. The cytoskeleton network is essential in regulating mitochondrial morphology and rearrangement, which are inextricably linked to its functions, such as oxidative phosphorylation (OXPHOS). The interaction between the cytoskeleton and mitochondria can enable CSCs to adapt to challenging conditions, such as a lack of energy sources, and to maintain their stemness. Cytoskeleton-mediated mitochondrial trafficking and relocating to the high energy requirement region are crucial steps in epithelial-to-mesenchymal transition (EMT). In addition, the cytoskeleton itself interplays with and blocks the voltage-dependent anion channel (VDAC) to directly regulate bioenergetics. In this review, we describe the regulation of cellular bioenergetics in CSCs, focusing on the cytoskeleton-mediated dynamic control of mitochondrial structure and function.
Peptide Binding Sites of Connexin Proteins
Authors: Simon Ágnes , Magyar Csaba , Héja László , Kardos Julianna
Published: July 2020

Intercellular gap junction (GJ) contacts formed by the coupling of connexin (Cx) hemichannels (HCs) embedded into the plasma membranes of neighboring cells play significant role in the development, signaling and malfunctions of mammalian tissues. Understanding and targeting GJ functions, however, calls for finding valid Cx subtype-specific inhibitors. We conjecture the lack of information about binding interactions between the GJ interface forming extracellular EL1 and EL2 loops and peptide mimetics designed to specifically inhibit Cx43HC coupling to Cx43GJ. Here, we explore active spots at the GJ interface using known peptide inhibitors that mimic various segments of EL1 and EL2. Binding interactions of these peptide inhibitors and the non-peptide inhibitor quinine has been modelled in combination with the use of blind docking molecular mechanics (MM). The neuron-specific Cx36HC and astrocyte-specific Cx43HC subtypes were modelled with a template derived from the high-resolution structure of Cx26GJ. GJ-coupled and free Cx36HC and Cx43HC models were obtained by dissection of GJs (GJ-coupled) followed by 50 ns molecular dynamics (free). Molecular mechanics (MM) calculations were performed by the docking of inhibitors, explicitly the designed Cx43 EL1 or EL2 loop sequence mimetics (GAP26, P5 or P180–195, GAP27, Peptide5, respectively) and the Cx36 subtype-specific quinine into the model structures. In order to explore specific binding interactions between inhibitors and CxHC subtypes, MM/Generalized Born Surface Area (MM/GBSA) ΔGbind values for representative conformers of peptide mimetics and quinine were evaluated by mapping the binding surface of Cx36HC and Cx43HC for all inhibitors. Quinine specifically contacts Cx36 EL1 residues V54-C55-N56-T57-L58, P60 and N63. Blocking the vestibule by the side of Cx36HC entry, quinine explicitly interacts with the non-conserved V54, L58, N63 residues of Cx36 EL1. In addition, our work challenges the predicted specificity of peptide mimetics, showing that the docking site of peptides is unrelated to the location of the sequence they mimic. Binding features, such as unaffected EL2 residues and the lack of Cx43 subtype-specificity of peptide mimetics, suggest critical roles for peptide stringency and dimension, possibly pertaining to the Cx subtype-specificity of peptide inhibitors.
A Review: Electrochemical Biosensors for Oral Cancer
Authors: Lin Yen-Tzu , Darvishi Sorour , Preet Anant , Huang Tzu-Yen , Lin Sheng-Hsuan , Girault Hubert H. , Wang Ligang , Lin Tzu-En
Published: July 2020

Oral cancer poses a serious threat worldwide owing to its soaring case-fatality rate and its metastatic characteristics of spreading to the other parts of the body. Despite the recent breakthroughs in biomedical sciences, the detection of oral cancer at an early stage is still challenging. Conventional diagnosis in clinics and optical techniques to detect oral cancer in the initial stages are quite complicated as well as not completely accurate. To enhance the survival rate of oral cancer patients, it is important to investigate the novel methodologies that can provide faster, simpler, non-invasive, and yet ultraprecise detection of the onset of oral cancer. In this review, we demonstrate the promising aspects of an electrochemical biosensor as an ideal tool for oral cancer detection. We discuss the cutting-edge methodologies utilizing various electrochemical biosensors targeting the different kinds of biomarkers. In particular, we emphasize on electrochemical biosensors working at the molecular levels, which can be classified into mainly three types: DNA biosensors, RNA biosensors and protein biosensors according to the types of the analytes. Furthermore, we focus on the significant electrochemical methods including cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) to analyze the oral cancer biomarkers (such as IL-6, IL-8, CYFRA 21-1, CD 59 and CIP2A) present in body fluids including saliva and serum, using non-invasive manner. Hence, this review provides essential insights into the development of pioneering electrochemical biosensors for the detection of oral cancer at an early stage.
Poverty, Child Labor, and Hope: The Relationship between Hope and Perceived Social Support in Children Working in Street Markets in TRC2 Region of Turkey
Authors: Sevinç Mehmet Reşit , Aydoğdu Mustafa Hakkı , Cançelik Mehmet , Binici Turan , Palabıçak Muhammed Ali
Published: July 2020

Diyarbakır and Şanlıurfa (TRC2 Region) are the cities within the provinces of Turkey that have a high prevalence of poverty with an associated high child population. Due to the poverty in the cities of Diyarbakır and Şanlıurfa, this study investigated children working as a carrier in six purposefully selected districts, street markets, with the aim of providing social support for them to look forward to the future with hope. The research was conducted in 2019 by using questionnaires through face-to-face interviews, to cover all children in selected street markets within the scope of the full sampling volume. The data were analyzed using a structural equation modeling method. According to the results, 61.2% of working children are students, but most of them do not go to attend school; 8.7% of working children are the children of the Syrian refugees. Children work an average of 4.3 days a week and 8.6 h a day, with an average income of USD 1.6/day. As a result of the analysis, it was shown that the children received the most social support from their schoolmates (r = 0.428) to have hope in the future. This result shows that it is compulsory to include children in the education system. In this context, it is recommended that the financial contribution of children to their families should be paid by the state within the scope of social assistance and solidarity. Besides, strengthening social awareness and providing solidarity would contribute to the solution of the problem. The data obtained from this research could be used in studies and policies, to develop the concept of hope for combating poverty in regions with similar socio-economic characteristics. This research is the first of its type conducted on this issue in Turkey.
Optimization of a Hybrid Solar PV and Gas Turbine Generator System Using the Loss of Load Probability Index
Authors: Atef Mohamed , Khatib Tamer , Abdullah Muhammad Faris , Romlie Mohd Fakhizan
Published: July 2020

In this paper, an optimization approach for designing a hybrid renewable energy system with zero load rejection is presented for a specific location in Malaysia. The proposed renewble energy system includes photovoltaic system, gas turbine generator and battery bank. The aim of the optimization process is to design the system with a loss of load probability that is less than 1%. An improved numerical algorithm is proposed in this paper. Moreover, a comparison between electrification options, including the existing gas-turbine-based generator (existing system), electricity grid and the proposed system, is presented in terms of the annualized total life-cycle cost. The results show that the proposed system can reduce the annual running cost by USD 2.1 million, while the electricity grid connection option can reduce the annual cost by USD 1.16 million as compared to the existing gas-turbine-based generator. In addition to this, the proposed optimization algorithm provides a reliable power system with zero load rejection based on simulation results.
On the Generation of Infinitely Many Conservation Laws of the Black-Scholes Equation
Authors: Sinkala Winter
Published: July 2020

Construction of conservation laws of differential equations is an essential part of the mathematical study of differential equations. In this paper we derive, using two approaches, general formulas for finding conservation laws of the Black-Scholes equation. In one approach, we exploit nonlinear self-adjointness and Lie point symmetries of the equation, while in the other approach we use the multiplier method. We present illustrative examples and also show how every solution of the Black-Scholes equation leads to a conservation law of the same equation.
Performance of Overset Mesh in Modeling the Wake of Sharp-Edge Bodies
Authors: Verma Suyash , Hemmati Arman
Published: July 2020

The wake dynamics of sharp-edge rigid panels is examined using Overset Grid Assembly (OGA) utilized in OpenFOAM, an open-source platform. The OGA method is an efficient solution technique based on overlap of a single or multiple moving grids on a stationary background grid. Five test cases for a stationary panel at different angle of attack are compared with available computational data, which show a good agreement in predicting global flow variables, such as mean drag. The models also provided accurate results in predicting the main flow features and structures. The flow past a pitching square panel is also investigated at two Reynolds numbers. The study of surface pressure distribution and shear forces acting on the panel suggests that a higher streamwise pressure gradient exists for the high Reynolds number case, which leads to an increase in lift, whereas the highly viscous effects at low Reynolds number lead to an increased drag production. The wake visualizations for the stationary and pitching motion cases show that the vortex shedding and wake characteristics are captured accurately using the OGA method.
Novel Trends in Lyotropic Liquid Crystals
Authors: Dierking Ingo , Martins Figueiredo Neto Antônio
Published: July 2020

We introduce and shortly summarize a variety of more recent aspects of lyotropic liquid crystals (LLCs), which have drawn the attention of the liquid crystal and soft matter community and have recently led to an increasing number of groups studying this fascinating class of materials, alongside their normal activities in thermotopic LCs. The diversity of topics ranges from amphiphilic to inorganic liquid crystals, clays and biological liquid crystals, such as viruses, cellulose or DNA, to strongly anisotropic materials such as nanotubes, nanowires or graphene oxide dispersed in isotropic solvents. We conclude our admittedly somewhat subjective overview with materials exhibiting some fascinating properties, such as chromonics, ferroelectric lyotropics and active liquid crystals and living lyotropics, before we point out some possible and emerging applications of a class of materials that has long been standing in the shadow of the well-known applications of thermotropic liquid crystals, namely displays and electro-optic devices.
Enhancement of Solar Cell Performance of Electrodeposited Ti/n-Cu2O/p-Cu2O/Au Homojunction Solar Cells by Interface and Surface Modification
Authors: Jayathilaka Charith , Kumara Loku Singgappulige Rosantha , Ohara Koji , Song Chulho , Kohara Shinji , Sakata Osami , Siripala Withana , Jayanetti Sumedha
Published: July 2020

Cuprous oxide (Cu2O) homojunction thin films on Ti substrates were fabricated by an electrochemical deposition in which a p-Cu2O layer was deposited on an n-Cu2O layer by carefully controlled bath conditions. It was found that the open-circuit voltage of the homojunction solar cell was significantly influenced by the pH of the lactate bath. The variation of the pH was used to achieve the best possible crystal orientation for homojunctions. The crystallinity and morphology of the products were characterized by X-ray diffraction (XRD), high-energy x-ray diffraction (HEXRD), and scanning electron microscopy (SEM). The current density voltage (J-V) analysis showed that the sulfur treatment and annealing enhanced the photocurrent by ten-fold compared to the untreated and unannealed homojunction solar cell. X-ray photoelectron spectroscopy (XPS) studies confirmed that the sulfur treatment eliminated the surface CuO and formed a thin layer of CuS, which was very useful to make the front Ohmic contact. Transient measurements confirmed that the p-type Cu2O layer, which was subjected to sulfur treatment, significantly reduced the recombination, thus enhancing the efficiency of the solar cell. The best sulfur treated annealed Ti/n-Cu2O/p-Cu2O/Au solar cell produced an energy conversion efficiency of 2.64% with an open-circuit voltage of 490 mV and a short circuit current density of 12.8 mA cm−2 under AM 1.5 illumination.
Solving Noise Pollution Issue Using Plenum Window with Perforated Thin Box
Authors: Lee Hsiao Mun , Haris Andi , Lim Kian Meng , Xie Jinlong , Lee Heow Pueh
Published: July 2020

In the present study, a conventional plenum window was incorporated with perforated thin box in order to enhance its performance at frequency range which centralized at 1000 Hz as most of the common noise sources at city nowadays are centralizing around this frequency. The entire studies were conducted in a reverberation room. The effectiveness of jagged flap on mitigating diffracted sound was also studied. Three types of noises were examined in the current study—white noise, traffic noise and construction noises. The experimental results showed that the plenum window with perforated thin box could reduce 8.4 dBA, 8.7 dBA and 6.9 dBA of white, traffic and construction noises, respectively. The jagged flaps did not have significant effect on the plenum window’s noise mitigation performance. When frequencies were ranging from 800 Hz to 1250 Hz, when compared with the case of without perforated thin box, it was found that the perforated thin box had good acoustic performance where it was able to reduce additional 1.6 dBA, 1.6 dBA and 1.2 dBA of white, construction and traffic noises, respectively.
Anthropometric and Biochemical Markers as Possible Indicators of Left Ventricular Abnormal Geometric Pattern and Function Impairment in Obese Normotensive Children
Authors: Giannisi Filippina , Keivanidou Anastasia , Sakellari Ioanna , Balala Sofia , Hassapidou Maria , Hitoglou-Makedou Areti , Giannopoulos Andreas
Published: July 2020

Εmerging data indicate that various effects of obesity on the cardiovascular system can be evident during childhood. The aim of this study was to detect early changes in left ventricular structure and function in obese normotensive children and explore possible associations of these changes with anthropometric and biochemical parameters. Normotensive 8–11-year-old obese and normal weight children were included in the study. They all underwent anthropometric measurements, laboratory tests, and echocardiography study by conventional and tissue Doppler to assess geometric pattern and function of left ventricle. Statistically significant differences in most anthropometric and metabolic parameters were noticed between groups. Obese children showed higher left ventricular mass index (LVMI) (40.05 ± 9.44 vs. 28.31 ± 6.22), lower E/A ratio (1.76 ± 0.33 vs. 2.08 ± 0.56), and higher E/e’ (6.04 ± 1.13 vs. 5.43 ± 0.96) compared to lean peers. Waist-to-height ratio and hs-CRP correlated significantly with E/A in the obese group. Left ventricular hypertrophy was present in 47.2% of obese children and eccentric was the prominent type. Waist-to-height ratio and serum cortisol levels in plasma increased the odds of having any type of abnormal ventricular geometric pattern. Echocardiographic evaluation of left ventricle and diastolic function could be considered for obese normotensive children based on waist-to-height ratio, hs-CRP, and serum cortisol.
Reference Percentiles and Changes over Time for Total Thyroxine in Preterm Infants: A Retrospective Cohort Study
Authors: Flores-Robles Claudia M. , Roldan-Valadez Ernesto , Martínez-Cruz Nayeli , Arce-Sánchez Lidia , Priego-Zurita Ana L. , Estrada-Gutierrez Guadalupe , Reyes-Muñoz Enrique
Published: July 2020

Hypothyroxinemia of prematurity increases the rate of false-positive results in total thyroxine (tT4)-based screening programs for congenital hypothyroidism. The use of specific cutoff values for preterm infants has been proposed, but data on tT4 reference ranges in this population are limited. The primary aim was to establish reference percentiles for tT4 in dried blood spots among Mexican preterm infants. Secondary aims included a comparison of the change of tT4 concentrations over time according to gestational age and to discuss its impact on tT4-based screening programs. This was a retrospective cohort study; 1561 preterm infants were included. Percentile 10th for tT4 concentration at 24–27, 28–30, 31–34, and 35–36 weeks of gestational age, measured in the first week of life was: 47.6, 56.6, 82.3, and 117.1 nmol/L, respectively. tT4 concentrations were compared in three different time points: first week of life, 2–3 weeks of life, and term-corrected gestational age (38 weeks of gestation), progressively increased in infants below 30 weeks, remained stable in infants from 31 to 34 weeks, and decreased in late preterm newborns (35–36 weeks). This study suggests that preterm infants may require the use of lower tT4 cutoff values in newborn screening.
A Vegan Athlete’s Heart—Is It Different? Morphology and Function in Echocardiography
Authors: Król Wojciech , Price Szymon , Śliż Daniel , Parol Damian , Konopka Marcin , Mamcarz Artur , Wełnicki Marcin , Braksator Wojciech
Published: July 2020

Plant-based diets are a growing trend, including among athletes. This study compares the differences in physical performance and heart morphology and function between vegan and omnivorous amateur runners. A study group and a matched control group were recruited comprising N = 30 participants each. Eight members of the study group were excluded, leaving N = 22 participants. Members of both groups were of similar age and trained with similar frequency and intensity. Vegans displayed a higher VO2max (54.08 vs. 50.10 mL/kg/min, p < 0.05), which correlated positively with carbohydrate intake (ρ = 0.52) and negatively with MUFA (monounsaturated fatty acids) intake (ρ = −0.43). The vegans presented a more eccentric form of remodelling with greater left ventricular end diastolic diameter (LVEDd, 2.93 vs. 2.81 cm/m2, p = 0.04) and a lower relative wall thickness (RWT, 0.39 vs. 0.42, p = 0.04) and left ventricular mass (LVM, 190 vs. 210 g, p = 0.01). The left ventricular mass index (LVMI) was similar (108 vs. 115 g/m2, p = NS). Longitudinal strain was higher in the vegan group (−20.5 vs. −19.6%, p = 0.04), suggesting better systolic function. Higher E-wave velocities (87 vs. 78 cm/s, p = 0.001) and E/e′ ratios (6.32 vs. 5.6, p = 0.03) may suggest better diastolic function in the vegan group. The results demonstrate that following a plant-based diet does not impair amateur athletes’ performance and influences both morphological and functional heart remodelling. The lower RWT and better LV systolic and diastolic function are most likely positive echocardiographic findings.
fNIRS Complexity Analysis for the Assessment of Motor Imagery and Mental Arithmetic Tasks
Authors: Ghouse Ameer , Nardelli Mimma , Valenza Gaetano
Published: July 2020

Conventional methods for analyzing functional near-infrared spectroscopy (fNIRS) signals primarily focus on characterizing linear dynamics of the underlying metabolic processes. Nevertheless, linear analysis may underrepresent the true physiological processes that fully characterizes the complex and nonlinear metabolic activity sustaining brain function. Although there have been recent attempts to characterize nonlinearities in fNIRS signals in various experimental protocols, to our knowledge there has yet to be a study that evaluates the utility of complex characterizations of fNIRS in comparison to standard methods, such as the mean value of hemoglobin. Thus, the aim of this study was to investigate the entropy of hemoglobin concentration time series obtained from fNIRS signals and perform a comparitive analysis with standard mean hemoglobin analysis of functional activation. Publicly available data from 29 subjects performing motor imagery and mental arithmetics tasks were exploited for the purpose of this study. The experimental results show that entropy analysis on fNIRS signals may potentially uncover meaningful activation areas that enrich and complement the set identified through a traditional linear analysis.
Achievable Information Rates for Probabilistic Amplitude Shaping: An Alternative Approach via Random Sign-Coding Arguments
Authors: Gültekin Yunus Can , Alvarado Alex , Willems Frans M. J.
Published: July 2020

Probabilistic amplitude shaping (PAS) is a coded modulation strategy in which constellation shaping and channel coding are combined. PAS has attracted considerable attention in both wireless and optical communications. Achievable information rates (AIRs) of PAS have been investigated in the literature using Gallager’s error exponent approach. In particular, it has been shown that PAS achieves the capacity of the additive white Gaussian noise channel (Böcherer, 2018). In this work, we revisit the capacity-achieving property of PAS and derive AIRs using weak typicality. Our objective is to provide alternative proofs based on random sign-coding arguments that are as constructive as possible. Accordingly, in our proofs, only some signs of the channel inputs are drawn from a random code, while the remaining signs and amplitudes are produced constructively. We consider both symbol-metric and bit-metric decoding.
Joint Fluctuation Theorems for Sequential Heat Exchange
Authors: Santos Jader , Timpanaro André , Landi Gabriel
Published: July 2020

We study the statistics of heat exchange of a quantum system that collides sequentially with an arbitrary number of ancillas. This can describe, for instance, an accelerated particle going through a bubble chamber. Unlike other approaches in the literature, our focus is on the joint probability distribution that heat Q 1 is exchanged with ancilla 1, heat Q 2 is exchanged with ancilla 2, and so on. This allows us to address questions concerning the correlations between the collisional events. For instance, if in a given realization a large amount of heat is exchanged with the first ancilla, then there is a natural tendency for the second exchange to be smaller. The joint distribution is found to satisfy a Fluctuation theorem of the Jarzynski–Wójcik type. Rather surprisingly, this fluctuation theorem links the statistics of multiple collisions with that of independent single collisions, even though the heat exchanges are statistically correlated.
Thermodynamic Analysis of a Hybrid Trigenerative Compressed Air Energy Storage System with Solar Thermal Energy
Authors: Chen Xiaotao , Xue Xiaodai , Si Yang , Liu Chengkui , Chen Laijun , Guo Yongqing , Mei Shengwei
Published: July 2020

The comprehensive utilization technology of combined cooling, heating and power (CCHP) systems is the leading edge of renewable and sustainable energy research. In this paper, we propose a novel CCHP system based on a hybrid trigenerative compressed air energy storage system (HT-CAES), which can meet various forms of energy demand. A comprehensive thermodynamic model of the HT-CAES has been carried out, and a thermodynamic performance analysis with energy and exergy methods has been done. Furthermore, a sensitivity analysis and assessment capacity for CHP is investigated by the critical parameters effected on the performance of the HT-CAES. The results indicate that round-trip efficiency, electricity storage efficiency, and exergy efficiency can reach 73%, 53.6%, and 50.6%, respectively. Therefore, the system proposed in this paper has high efficiency and flexibility to jointly supply multiple energy to meet demands, so it has broad prospects in regions with abundant solar energy resource.
Susceptible-Infected-Susceptible Epidemic Discrete Dynamic System Based on Tsallis Entropy
Authors: Momani Shaher , Ibrahim Rabha , Hadid Samir
Published: July 2020

This investigation deals with a discrete dynamic system of susceptible-infected-susceptible epidemic (SISE) using the Tsallis entropy. We investigate the positive and maximal solutions of the system. Stability and equilibrium are studied. Moreover, based on the Tsallis entropy, we shall formulate a new design for the basic reproductive ratio. Finally, we apply the results on live data regarding COVID-19.
MiniTEE—A Lightweight TrustZone-Assisted TEE for Real-Time Systems
Authors: Liu Songran , Guan Nan , Guo Zhishan , Yi Wang
Published: July 2020

While trusted execution environments (TEEs) provide industry standard security and isolation, TEE requests through secure monitor calls (SMCs) attribute to large time overhead and weakened temporal predictability. Moreover, as current available TEE solutions are designed for Linux and/or Android initially, it will encounter many constraints (e.g., driver libraries incompatible, large memory footprint, etc.) when integrating with low-end Real-Time Operating Systems, RTOSs. In this paper, we present MiniTEE to understand, evaluate and discuss the benefits and limitations when integrating TrustZone-assisted TEEs with RTOSs. We demonstrate how MiniTEE can be adequately exploited for meeting the real-time needs, while presenting a low performance overhead to the rich OSs (i.e., low-end RTOSs).
Design and Implementation of a Compact Single-Photon Counting Module
Authors: Chen Ming , Li Chenghao , Morrison Alan P. , Deng Shijie , Teng Chuanxin , Liu Houquan , Deng Hongchang , Xiong Xianming , Yuan Libo
Published: July 2020

A compact single-photon counting module that can accurately control the bias voltage and hold-off time is developed in this work. The module is a microcontroller-based system which mainly consists of a microcontroller, a programmable negative voltage generator, a silicon-based single-photon avalanche diode, and an integrated active quench and reset circuit. The module is 3.8 cm × 3.6 cm × 2 cm in size and can communicate with the end user and be powered through a USB cable (5 V). In this module, the bias voltage of the single-photon avalanche diode (SPAD) is precisely controllable from −14 V ~ −38 V and the hold-off time (consequently the dead time) of the SPAD can be adjusted from a few nanoseconds to around 1.6 μs with a setting resolution of ∼6.5 ns. Experimental results show that the module achieves a minimum dead time of around 28.5 ns, giving a saturation counting rate of around 35 Mcounts/s. Results also show that at a controlled reverse bias voltage of 26.8 V, the dark count rate measured is about 300 counts/s and the timing jitter measured is about 158 ps. Photodetection probability measurements show that the module is suited for detection of visible light from 450 nm to 800 nm with a 40% peak photon detection efficiency achieved at around 600 nm.
Optimization of the Sensitivity of a Double-Dot Magnetic Detector
Authors: Macucci Massimo , Marconcini Paolo , Roche Stephan
Published: July 2020

We investigate, by means of numerical simulations, the lowest magnetic field level that can be detected with a given relative accuracy with a sensor based on a double-dot device fabricated in a high-mobility two-dimensional electron gas. The double dot consists of a cavity delimited by an input and an output constriction, with a potential barrier exactly in the middle. In conditions of perfect symmetry, a strong conductance enhancement effect appears as a consequence of the constructive interference between symmetric trajectories. When the symmetry is broken, for example by the presence of an applied magnetic field, this enhancement effect is suppressed. We explore the design parameter space and assess the minimum magnetic field value that can be measured with a given accuracy in the presence of flicker noise.
THz CMOS On-Chip Antenna Array Using Defected Ground Structure
Authors: Lee Changmin , Jeong Jinho
Published: July 2020

In this paper, we design a THz CMOS on-chip patch antenna with defected ground structure (DGS) and utilize it to implement a broadband and high gain on-chip antenna array. It is verified from the simulation that the DGS not only can increase the gain and bandwidth of the antenna element, but also can increase the isolation between the antenna elements in the on-chip array. Therefore, it allows the design of the compact 1 × 2 and 2 × 2 on-chip antenna array with high gain and broad bandwidth. The element spacing and feedline structures of the antenna array are designed and optimized by the simulations. The designed antenna element, and 1 × 2 and 2 × 2 antenna arrays are fabricated in a commercial 65 nm CMOS process. In the on-wafer measurement, they exhibit an antenna gain of 3.1 dBi, 7.2 dBi, and 8.2 dBi with a bandwidth of 14.0%, 21.3%, and 28.0% for the reflection coefficient less than −10 dB, respectively, at 300 GHz. This result corresponds to very good performance compared to the reported THz CMOS on-chip antenna array. Therefore, the designed CMOS on-chip antenna element and array using DGS in this work can be effectively applied to build low-cost and high performance THz systems, because they can be fully implemented in a conventional CMOS process without requiring any additional processes or manufacturing techniques.
Heat Transfer through Wire Cloth Micro Heat Exchanger
Authors: Walter Christian , Martens Sebastian , Zander Christian , Mehring Carsten , Nieken Ulrich
Published: July 2020

The main objective of this study is to calculate and determine design parameters for a novel wire cloth micro heat exchanger. Wire cloth micro heat exchangers offer a range of promising applications in the chemical industry, plastics technology, the recycling industry and energy technology. We derived correlations to calculate the heat transfer rate, pressure drop and temperature distributions through the woven structure in order to design wire cloth heat exchangers for different applications. Computational Fluid Dynamics (CFD) simulations have been carried out to determine correlations for the dimensionless Euler and Nusselt numbers. Based on these correlations, we have developed a simplified model in which the correlations can be used to calculate temperature distributions and heat exchanger performance. This allows a wire cloth micro heat exchanger to be virtually designed for different applications.
Evaluation of Actuator Disk Model Relative to Actuator Surface Model for Predicting Utility-Scale Wind Turbine Wakes
Authors: Li Zhaobin , Yang Xiaolei
Published: July 2020

The Actuator Disk (AD) model is widely used in Large-Eddy Simulations (LES) to simulate wind turbine wakes because of its computing efficiency. The capability of the AD model in predicting time-average quantities of wind tunnel-scale turbines has been assessed extensively in the literature. However, its capability in predicting wakes of utility-scale wind turbines especially for the coherent flow structures is not clear yet. In this work, we take the time-averaged statistics and Dynamic Mode Decomposition (DMD) modes computed from a well-validated Actuator Surface (AS) model as references to evaluate the capability of the AD model in predicting the wake of a 2.5 MW utility-scale wind turbine for uniform inflow and fully developed turbulent inflow conditions. For the uniform inflow cases, the predictions from the AD model are significantly different from those from the AS model for the time-averaged velocity, and the turbulence kinetic energy until nine rotor diameters (D) downstream of the turbine. For the turbulent inflow cases, on the other hand, the differences in the time-averaged quantities predicted by the AS and AD models are not significant especially at far wake locations. As for DMD modes, significant differences are observed in terms of dominant frequencies and DMD patterns for both inflows. Moreover, the effects of incoming large eddies, bluff body shear layer instability, and hub vortexes on the coherent flow structures are discussed in this paper.
The Effects of Gravity on the Pressure Drop and Heat Transfer Characteristics of Steam in Microchannels: An Experimental Study
Authors: Doan Minhhung , Dang Thanhtrung , Nguyen Xuanvien
Published: July 2020

Experiments were carried out to investigate the pressure drop and heat transfer behaviors of a microchannel condenser. The effects of gravity on the condensation of steam in the microchannels were investigated for both horizontal and vertical cases. For the experimental results, the pressure drop of vertical microchannels in the condenser is lower than for horizontal microchannels. In the case of the horizontal microchannel, as the mass flow rate of steam increases from 0.01 g·s−1 to 0.06 g·s−1, the pressure drop increases from 1.5 kPa to 50 kPa, respectively. While the mass flow rate of steam in the vertical microchannel case increases from 0.01 g·s−1 to 0.06 g·s−1, the pressure drop increases from 2.0 kPa to 44 kPa, respectively. This clearly indicates that the gravitational acceleration affects the pressure drop. The pressure drop of the vertical microchannel is lower than that obtained from the horizontal microchannel. In addition, the capacity of the condenser is the same in both cases. This leads to the performance index obtained from the vertical microchannel condenser being higher than that obtained from the horizontal microchannel condenser. These results are important contributions to the research on the condensation of steam in microchannels.
Modeling and Managing Joint Price and Volumetric Risk for Volatile Electricity Portfolios
Authors: Kaufmann Johannes , Kienscherf Philipp Artur , Ketter Wolfgang
Published: July 2020

With an increasing share of renewable energy resources participating in electricity markets, there is a growing dependence between renewable power production and clearing prices of spot markets. Modeling this dependence using bivariate analysis can result in underestimation of market risks and adverse effects for stakeholders’ risk management. To enable an undistorted risk assessment, we are using a copula approach to precisely and jointly model electricity prices and infeed volumes of wind power. We simulate the case of wind farm operators using power purchase agreements (PPAs) to shift the price risk to an energy trader, who integrates the infeed into its portfolio. The trader’s portfolio can either be geographically dispersed, or highly localized. Based on its portfolio, the energy trader can decide to use derivatives such as futures to manage its risk exposure. The trader decides on future volumes subject to its portfolio’s inherent volatility. With a given risk averse strategy, a sufficiently diverse portfolio can help reduce the necessity to trade futures and subsequently the disadvantage of having to pay potential risk premiums.
Reviewing ISO Compliant Multifunctionality Practices in Environmental Life Cycle Modeling
Authors: Moretti Christian , Corona Blanca , Edwards Robert , Junginger Martin , Moro Alberto , Rocco Matteo , Shen Li
Published: July 2020

The standard ISO 14044:2006 defines the hierarchical steps to follow when solving multifunctionality issues in life cycle assessment (LCA). However, the practical implementation of such a hierarchy has been debated for twenty-five years leading to different implementation practices from LCA practitioners. The first part of this study discussed the main steps where the ISO hierarchy has been implemented differently and explored current multifunctionality practices in peer-reviewed studies. A text-mining process was applied to quantitatively assess such practices in the 532 multifunctional case studies found in the literature. In the second part of the study, citation network analysis (CNA) was used to identify the major publications that influenced the development of the multifunctionality-debate in LCA, i.e., the key-route main path. The identified publications were then reviewed to detect the origins of the different practices and their underlying theories. Based on these insights, this study provided some “food for thought” on current practices to move towards consistent methodology. We believe that such an advancement is urgently needed for better positioning LCA as a tool for sustainability decision-making. In particular, consistent allocation practices could be especially beneficial in bioeconomy sectors, where production processes are usually multifunctional, and where current allocation practices are not harmonized yet.
Development of a Multiphysics Real-Time Simulator for Model-Based Design of a DC Shipboard Microgrid
Authors: D’Agostino Fabio , Kaza Daniele , Martelli Michele , Schiapparelli Giacomo-Piero , Silvestro Federico , Soldano Carlo
Published: July 2020

Recent and strict regulations in the maritime sector regarding exhaust gas emissions has led to an evolution of shipboard systems with a progressive increase of complexity, from the early utilization of electric propulsion to the realization of an integrated shipboard power system organized as a microgrid. Therefore, novel approaches, such as the model-based design, start to be experimented by industries to obtain multiphysics models able to study the impact of different designing solutions. In this context, this paper illustrates in detail the development of a multiphysics simulation framework, able to mimic the behaviour of a DC electric ship equipped with electric propulsion, rotating generators and battery energy storage systems. The simulation platform has been realized within the retrofitting project of a Ro-Ro Pax vessel, to size components and to validate control strategies before the system commissioning. It has been implemented on the Opal-RT simulator, as the core component of the future research infrastructure of the University of Genoa, which will include power converters, storage systems, and a ship bridge simulator. The proposed model includes the propulsion plant, characterized by propellers and ship dynamics, and the entire shipboard power system. Each component has been detailed together with its own regulators, such as the automatic voltage regulator of synchronous generators, the torque control of permanent magnet synchronous motors and the current control loop of power converters. The paper illustrates also details concerning the practical deployment of the proposed models within the real-time simulator, in order to share the computational effort among the available processor cores.