bluuebunny/crossref_metadata_2025 huggingface dataset:
TOWARDS A SUSTAINABLE TRANSPORT IN ALGERIA: THE REQUISITE OF ENERGY TRANSITION IN THE ROAD TRANSPORT SECTOR
Authors: CHETTAH Saif Eddine , NAIT AMAR Nadra
Published: July 2021

Less than ten years ago, Algeria embarked on an energy transition with the objectives of sustainable development. Although it concerns all economic sectors, efforts made in the field of road transport, as the main polluter and energy consumer at the national level, are far from being sufficient despite its inclusion in policy statements. This sector is operational exclusively on fossil and exhaustible energies whereas its atmospheric pollutants and gaseous emissions are highly harmful to the environment, public health and the economy. Thus, this paper points out the emergency of an energy transition in the road transport sector to clean and renewable energy as a necessity rather than a choice. It highlights, first, the characteristics of the Algerian automobile fleet and its various impacts and damages on the environment, public health and the economy. Furthermore, it evaluates the various policy initiatives towards sustainable transport and their deficiencies. Hence, the right attitudes and regulatory instruments towards sustainable transport in Algeria are recommended.
INFLUENCE OF PLASTIC DEFORMATION CARBON STEEL ON THE PROCESS OF BURNING ELECTRIC ARC
Authors: VAKULENKO Igor Alex , PLITCHENKO Sergey , KURT Bulent , ASKEROV Hangardas , PROYDAK Svetlana , ERDOGDU Ahmet Emrah
Published: July 2021

During a study of the combustion process of a direct polarity electric arc, a directly proportional dependence of the electric current value on the degree of cold plastic deformation of carbon steel used as an electrode was found. To calculate the value of the electric current during arc burning, in the indicated ratio, it was proposed to replace the surface tension force of the liquid metal with the surface tension of ferrite of plastically deformed carbon steel. Calculation of the ferrite’s surface tension value on the deformation degree of the steel under study through the size of the coherent scattering regions was used to explain the observed dependence of the electric current during arc burning. From the analysis of the considered correlation ratios, it was found that with an increase in the cold deformation degree, the refinement of the coherent scattering regions results in the ferrite’s surface tension increase and consequently, to an increase in the electric current during arc burning. Comparative analysis of the obtained results of calculating the value of electric current during arc burning through the surface tension of ferrite of cold-deformed carbon steel showed a fairly good coincidence with experimental data. The differences did not exceed 9%.
ROLE, PLACE AND INTERPRETATION OF INFORMATION IN THE CONTEXT OF CREATION OF INFORMATION MODEL AS WEB SITE
Authors: Šimunić Mislav
Published: July 2021

Centralna značajka svih živih bića jest informacija koja se nalazi u njima i oko njih i to za sve postojeće tokove radnji. Procesi prilikom prijenosa informacije igraju osnovnu ulogu unutar i između svega što živi. U ovome je radu naglasak na informaciji u sklopu poslovnih procesa. Pored svih svjetskih računala i superračunala, najkompleksniji sustav koji obrađuje informaciju jest bez sumnje čovjek, stoga načinu, vrsti, intenzitetu i strukturi plasiranja iste treba posvetiti veliku pažnju. U ovome radu naglasak analiziraju se web čvorovi kao MultiMedijski Informacijski Modeli (MM IM), te navode pravila i koncepcije za kreiranje kvalitetnih i funkcionalnih web čvorova u hotelskoj industriji. U današnjim sve dinamičnijim tržišnim promjenama i web čvorovi moraju sve više poprimati karakteristike dinamičkih modela i to ne samo u tehničkom već i u sadržajnom smislu.
Cross-border regions as potential tourist destinations along the Slovene-Croatian frontier
Authors: Vodeb Ksenija
Published: July 2021

The competitiveness of border regions is generally lower than that of a country’s interior regions. Typically being areas that mark the end of one entity and the beginning of another, border region demonstrate weaker economic performance. Tourism, as a method of development, provides opportunities to develop destinations in places where tourism attractions and resources, and comparative and competitive advantages, exist. Our research focuses on tourism supply providers in the border regions of Slovenia and Croatia. We assess their attitudes on tourism, regional competitiveness, and potential tourism destinations as the outcome of cooperation between the two countries in the field of tourism. Results indicate the possibility of enhancing competitiveness through a strategic approach to planning and managing cross-border tourism destinations.
Pelatihan Pemanfaatan Limbah Plastik Menjadi Berbagai Kreasi Daur Ulang Bagi Masyarakat Desa Penyak
Authors:   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung, Tiandho Yuant , Aldila Herman ,   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung, Widyaningrum Yekti ,   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung, Kusmita Tri ,   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung, Indriawati Anisa ,   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung, Kurniawan Widodo B. ,   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung, Afriani Fitri ,   Jurusan Fisika, Fakultas Teknik, Universitas Bangka Belitung
Published: July 2021

As an archipelago, handling plastic waste in the Province of Bangka Belitung Islands is an aspect that needs to be taken seriously. Apart from being focused on developing tourist areas, plastic waste will easily be carried to the sea and prone to be degraded into microplastics, often consumed by marine animals. This community service activity focuses on Penyak Village, Kec. Koba, Kab. Central Bangka, Bangka Belitung Islands. To solve the plastic problem in that location, the community service team conducted training for the community, especially for Pendidikan Kesejahteraan Keluarga (PKK) members, related to processing plastic waste into various recycled creations such as bags, pencil cases, and different kinds of souvenirs. The training program is carried out by providing materials and direct training to increase the understanding and skills. To broaden people's insights, the team conducted training with the Ecoplantstic start-up, which focuses on developing waste-based products. Through the evaluation, it is known that the training provided can improve the knowledge and skills of the community in processing plastic waste into various recycled creations, and several participants plan to develop the skills acquired for entrepreneurial purposes.
Teknologi Pengolahan Minuman Rempah Instan Sebagai Peluang Usaha Serta Meningkatkan Daya Tahan Tubuh Terhadap Covid 19
Authors:   Program Studi Teknologi Industri Agro/Politeknik ATI Padang, Senjawati Maria Isfus , Maryam Maryam ,   Program Studi Teknologi Industri Agro/Politeknik ATI Padang, Afriyuni Fera ,   Program Studi Teknologi Industri Agro/Politeknik ATI Padang
Published: July 2021

We are currently faced with the problem of the Covid 19 pandemic and no cure has been found. One of the efforts made by the community is to implement health protocols to the recommendations from the government and increase the body's resistance to prevent this Covid 19 attack. Indonesia has a wealth of spices that are quite large in number and type. According to some studies that this spice can increase the body's resistance because it contains antioxidants and active compounds that can ward off free radicals. This is one of the business opportunities as well as an effort to increase the body's endurance if consumed. Community service activities organized by ATI Padang Polytechnic, Agro Industry Engineering Study Program aims to provide technology for processing instant spice drinks based on red ginger. The spices used are red ginger, cinnamon, cloves and lemongrass. The product produced is instant red ginger. Partners of this activity are UKM/communities in Bungo Pasang Subdistrict, Koto Tangah District, Padang. The method used is to deliver processing technology through virtual training and practice independently. After attending virtual training and independent practice using equipment and materials that have been assisted by team, participants submitted their products that have been packaged as evaluation materials. It is hoped that with this activity, UKM/communities can produce this product in order to increase the resilience of the family as well as their business choice. The processing of spices into instant beverage products is expected to be widely marketed, more durable and provide added value to spice commodities. Kata kunci : Minuman instan, rempah, daya tahan tubuh
Enhancing the Cell-Free Expression of Native Membrane Proteins by in-Silico Optimisation of the Coding Sequence - An Experimental Study of the Human Voltage-Dependent Anion Channel
Authors: Zayni Sonja , Damiati Samar , Moreno-Flores Susana , Amman Fabian , Hofacker Ivo , Ehmoser Eva Kathrin
Published: July 2021

The investigation of membrane proteins, key constituents of cells, is hampered by the difficulty and complexity of their in vitro synthesis, of unpredictable yield. Cell-free synthesis is herein employed to unravel the impact of the expression construct on gene transcription and translation, without the complex regulatory mechanisms of cellular systems. Through the systematic design of plasmids in the immediacy of the start of the target gene, it was possible to identify translation initiation and the conformation of mRNA as the main factors governing the cell-free expression efficiency of the human voltage dependent anion channel (VDAC), a relevant membrane protein in drug-based therapy. A simple translation initiation model was developed to quantitatively assess the expression potential for the designed constructs. A scoring function is proposed that quantifies the feasibility of formation of the translation initiation complex through the ribosome-mRNA hybridization energy and the accessibility of the mRNA segment binding to the ribosome. The scoring function enables to optimize plasmid sequences and semi-quantitatively predict protein expression efficiencies. This scoring function is publicly available as webservice XenoExpressO at rna.tbi.univie.ac.at.
Catholic School Religious Education in a Secular, De-traditionalised Culture: The Formula that is Best for Both the Religious and Non-religious Students
Authors: Rossiter Graham
Published: July 2021

Philip Phenix’s (1964) book Realms of meaning started the ever growing movement concerned with how school education might help young people in their search for meaning in times of rapid social change. Today, in globalised, digital, secularised, de-traditionalised culture, the importance and urgency of this role have never been greater. Cultural change has accelerated exponentially, and for many – including students in religious/Catholic schools – traditional religious sources of meaning are no longer prominent or plausible reference points. Catholic schools, whether independent or semi-state institutions because of government funding, can make a valuable contribution young people’s spiritual/moral education, no matter what their level of religious affiliation or practice. This article argues that such a contribution requires change to the discourse or narrative of Catholic school Religious Education, with corresponding adjustments to content and pedagogy. Its present trajectory, which is excessively concerned with promoting a Catholic identity in students, needs to be modified. Both the religious and non-religious students, especially in the senior classes, would derive greater spiritual and religious benefit from the inclusion of more life-relevant and issue-related content, together with a critical, research-oriented pedagogy. Such an approach proposes that the Catholic Church’s schools should offer unconditionally a meaningful spiritual/moral education that is relevant to all students, rather than a traditional one which seemed to presume that all students are, or should be practising Catholics. This does not minimise attention to the Catholic tradition, but it allows for a study of how people negotiate the task of constructing meaning and values in a complex culture. The article also looks at the ‘headwinds’ that hinder the implementation of this approach. The article is focused specifically on the Australian context where Catholic schools are semi-state institutions because they are funded by both state and federal governments. The issues are still likely to be pertinent to Catholic education in other countries, while taking into account significant contextual differences.
Comparison of Ground Reaction Forces between Combat Boots and Sports Shoes
Authors: Rico Bini Rodrigo , Kilpp Daniel D. , Junior Pedro D. , Muniz Adriane D.
Published: July 2021

It is unclear whether military shoes (combat boots and sports shoes) attenuate loading rate or affect force transfer during walking. Therefore, this study compared ground reaction forces (GRF) related to impact and force transfer between combat boots, military sports shoes and running shoes. Ten army recruits walked over a walkway with two force plates embedded. GRF were measured when walking barefoot (for data normalization) and with combat boots, military sports shoes and running shoes. Loading rate, first and second peak forces and push-off rate of force were computed along with temporal analysis of waveforms. Reduced loading rate was observed for the running shoe compared to the combat boot (p = 0.02 and d = 0.98) and to the military sports shoe (p = 0.04 and d = 0.92). The running shoe elicited a smaller second peak force than the combat boot (p < 0.01 and d = 0.83). Walking with military shoes and combat boots led to larger force transfer then running shoes potentially due to harder material used in midsole composition (i.e. styrene-butadiene rubber). These results could lead to a potentially larger risk of injuries while long duration walking in military shoes and boots compared to traditional running shoes.
Raspberry Pi for Autonomous Home Farm Control
Authors: Rakhmatulin Ildar
Published: July 2021

This manuscript presented an autonomous home farm for predicting metrological characteristics that can not only automate the process of growing crops but also, due to a neural network, significantly increase the productivity of the farm. The developed farm monitors and manages the following indicators: illumination, soil PH, air temperature, earth temperature, air humidity, CO2 concentration, and soil moisture. The presented farm can also be considered as a device for testing various weather conditions to determine the optimal temperature characteristics for different crops. This farm as a result is completely autonomous grows tomatoes at home.
Oral probiotics in women's health: experimental evidence and results from clinical trials
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shikh E.V. , Makhova A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Sharonova S.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: July 2021

The review presents data from experimental research of the anti-inflammatory activity of Lactobacillus paracasei, L. plantarum, L. rhamnosus, the antitumor activity of L. rhamnosus GG and GR-1, L. gasseri, L. crispatus. The prospect of using probiotics in cancer treatment regimens with the aim to increase the tolerability of treatment was considered. The data confirming the ability of probiotic lactobacilli (L. reuteri and L. rhamnosus) to enhance barrier functions of endometrial epithelial cells in response to human papillomavirus-1 were presented. The perspectives of using microbiota modulation to prevent and/or protect the reproductive system against infection were discussed. The data of clinical trials using multi-strain probiotics containing Lactobacillus and Bifidobacterium in women with gestational diabetes were analyzed. A hypothesis on the role of microbiota in the pathogenesis of polycystic ovary syndrome (PCOS) was presented. Research results suggest that the use of probiotics can increase fertility in PCOS. Key words: viral infections, gestational diabetes mellitus, gynecological cancer, oral probiotics, polycystic ovary syndrome, Lactobacillus spp.
Adenomyosis. What has changed since the advent of ICD-11?
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Davydov A.I. , Tairova M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   S.S.Yudin City Clinical Hospital of the Department of Healthcare of the city of Moscow, Moscow, Russian Federation, Mikhaleva L.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   Research Institute of Human Morphology, Moscow, Russian Federation, Kaviladze M.G. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chilova R.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: July 2021

Over the years, it has been discussed that adenomyosis is not merely endometriosis of the uterus, but an independent disease with its inherent pathogenesis and clinical mechanisms. Adenomyosis and endometriosis are distinguished not only by pathogenesis, but also by features of histopathology. In the updated International Classification of Diseases, 11th revision (ICD-11), adenomyosis is not included in the section of endometriosis (GA10 Endometriosis), but is listed under a separate heading (GA11 Adenomyosis). In the description of adenomyosis, its former synonym, endometriosis of the uterus, is no longer present. This calls the need to rethink approaches to the diagnosis and treatment of adenomyosis. “Rejuvenation” of adenomyosis requires innovative treatment methods for such patients. When the conditions are met, intrauterine endosurgery in combination with postoperative hormonal therapy makes it possible to create the most favorable conditions for subsequent conception. If it is impossible to use an intrauterine device with levonorgestrel as hormonal therapy, preference should be given to the 4th generation progestogen – dienogest. When taken daily, dienogest is no less effective than gonadotropin-releasing hormone agonists, but has fewer restrictions on the duration of the course of therapy and has acceptable safety, tolerability, and a lower frequency of hot flashes. Key words: adenomyosis, histogenesis, dienogest, treatment, pathogenesis, endometriosis
The role of lactobacilli in restoring normal vaginal microbiota
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Dobrokhotova Yu.E. , Bondarenko K.R. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Shadrova P.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: July 2021

Achievements of modern science in the field of clinical microbiology, immunology and genetics help to take a different view of the significance of microflora for the human body on the whole. The role of various microorganisms in maintaining the normalization of the female reproductive system is constantly discussed in world literature. The emergence of the method of mass spectrometry has made it possible to identify several hundred types of microorganisms and determine the dominant. Vaginal microbiota is the first line of protection against pathogenic microorganisms in the genital tract. Changes in the content of healthy vaginal microbiome can affect vaginal homeostasis, reducing protective capabilities of the body and thereby increasing women’s susceptibility to infections of the lower genital tract. In addition, the vaginal microbiota plays an important role during pregnancy and childbirth, forming the neonatal microbiome. Despite the importance of studying the patterns of dominance of various types of lactobacilli in the vaginal biotope, there is currently little evidence of their protective function in relation to the female reproductive tract, which remains the subject of study. This knowledge gap is a challenge to the development of effective and applicable treatment methods with probiotic drugs, followed by an assessment of their effectiveness to protect and improve the reproductive health of the female population. Ke ywords: bacterial vaginosis, pregnancy, vaginal probiotics, vaginal microbiome, lactobacillus species identification, lactobacilli, lactic acid
The effect of demographic and anthropometric indicators on the amount of antithrombin III in patients with severe pre-eclampsia
Authors:   V.I.Vernadsky Crimean Federal University, Simferopol, Russian Federation, Pylaeva N.Yu. , Shifman E.M. ,   M.F.Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russian Federation, Kulikov A.V. ,   Ural State Medical University, Ekaterinburg, Russian Federation
Published: July 2021

A natural anticoagulant antithrombin III can serve as a possible marker of severe pre-eclampsia. The concentration variability of antithrombin III is known, depending on some demographic and anthropometric patient data. Objective. To study the connection between antithrombin III levels and the values of demographic and anthropometric indicators in patients with severe pre-eclampsia and normal pregnancy. Patients and methods. In order to achieve the objective of the study, two groups of 50 pregnant women in each were formed. Indicators were evaluated using the paired comparison method. Such indicators were age, presence or absence of obesity, ationality and gestation period. Results. Studies showed that the presence of obesity in pregnant women is accompanied by a decrease in the level of antithrombin III, more pronounced in severe pre-eclampsia. The group of pregnant women with the lowest level of antithrombin III against the background of severe pre-eclampsia was also determined, depending on the nationality: among the Crimean Tatars, they were pregnant with obesity, regardless of age, and among the Slavs – pregnant women who had increased body mass index combined with older age. Conclusion. The data obtained revealed the features of the connection between anthropometric and demographic indicators of patients with severe pre-eclampsia and the level of antithrombin III, allowing the use of antithrombin III as a prognostic marker of severe pre-eclampsia. Key words: antithrombin III, marker, complications, prognosis, severe pre-eclampsia
Non-hormonal treatment for genitourinary syndrome of menopause
Authors:   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Tatarova N.A. ,   Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russian Federation, Linde V.A. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Gusev S.N. ,   Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russian Federation
Published: July 2021

The genitourinary syndrome of menopause (GSM) is due to the development of atrophic and dystrophic processes in estrogendependent tissues and structures of the lower third of urinary tract in different periods of aging of the reproductive system. Nonhormonal treatment for GSM is considered as a first-line treatment and includes the use of gels, creams and suppositories that contribute to the restoration of hydrolipid balance, stimulating the collagen production that have an anti-inflammatory, antiseptic, regenerating effect, as well as increasing mucosal resistance and reducing the risk of adhesion of conditionally pathogenic infection. Objective. To evaluate the effectiveness, safety and acceptability of the vaginal cream for intimate hygiene EstrogialTM Plus in women with symptoms of vulvovaginal atrophy (VVA) and GSM. Patients and methods. 24 women aged 43 to 58 were examined. The inclusion criteria were the symptoms of GSM and VVA, the vaginal health index – no more than 20 points. During the course of the study, four visits were carried out, including standard observational procedures, filling the Quality of Life Questionnaire, the administration of treatment. The application of the cream Estrogial™ Plus in doses was prescribed 1 time per day on the vulvar vestibule for 30 days. The effectiveness of therapy was evaluated, all patients continued therapy for up to 60 days. According to the modified questionnaire for general clinical assessment, the state «very much improved» was revealed in 83.3% of patients with a severe form of GSM and VVA and in 66.7% with moderate VVA, «much improved» – in the rest. After treatment, 52% of patients had no symptoms of VVA, and 48% had symptoms in a mild form. Filling the Menopause-Specific Quality of Life Questionnaire (MENQOL), all 24 patients reported positive effects in the form of increased libido and reduced vaginal dryness during sexual intercourses. The study presents clinical cases of cured patients with GSM and VVA. Conclusion. The data obtained during the study make it possible to conclude that the intravaginal administration of the cream EstrogialTM Plus in doses is effective for the treatment of GSM and VVA. The proven therapeutic effects and safety of the use of local non-hormonal treatment enhance the prospects for providing treatment and preventive care for women during the menopausal transition and menopause. Key words: vulvovaginal atrophy, genitourinary syndrome of menopause, non-hormonal treatment, Estrogial™ Plus
Prenatal diagnosis of persistent right umbilical veins
Authors:   Clinical Hospital No 9, Yaroslavl, Russian Federation, Karpov A.Yu. , Zykova A.P. ,   Yaroslavl State Medical University, Yaroslavl, Russian Federation, Shiferson G.S. ,   Yaroslavl State Medical University, Yaroslavl, Russian Federation
Published: July 2021

Objective. To determine the incidence of persistent right umbilical vein (PRUV), as well as to study the prognostic value of as a marker of fetal developmental anomalies and neonatal outcomes. Patients and methods. 12,945 pregnant women whose gestation period was 18–41 weeks were examined. Ultrasound scanning was performed using a 3–5 MHz probe. A detailed fetal anatomy assessment was carried out, PRUV was diagnosed on the transverse scan of the fetal abdominal cavity. Results. 23 fetuses with PRUV were revealed: in 22 fetuses – an intrahepatic PRUV as a single anomaly was found, in 1 fetus – an extrahepatic PRUV (frequency 1:562). In all cases of intrahepatic PRUV, associated anomalies of fetal development were not revealed, pregnancy proceeded without complications with a favorable postnatal outcome. In one case of extrahepatic PRUV, cardiomegaly and hyper-echogenic bowel were diagnosed. Conclusion. The presence of PRUV in fetus is a marker of developmental anomalies and it warns a doctor about possible complications. Pregnancy, complicated by PRUV, requires a detailed dynamic observation, as in 30% of cases, there is a fetal growth retardation. The results of our study indicate that PRUV, when it is the only anomaly, has a favorable outcome, but based on the data of other authors, the fetus should be more carefully examined for other congenital malformations. Key words: persistent right umbilical vein, prenatal diagnosis, ultrasound diagnosis
Role of the audit of delivery methods for optimizing the indications for cesarean section and reducing its frequency in clinical practice
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Churganova A.A. , Gurzhikhanova M.Kh. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Alieva F.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Fedorina S.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ignatko I.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Martirosova A.L. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: July 2021

Objective. To analyze the frequency of indications for cesarean section (CS) and optimize obstetric tactics on the example of a level 3 perinatal center. Materials and methods. We performed retrospective analysis of 7,672 deliveries. Results. The indications for CS included abnormal labour (150; 6.3%), fetal distress (120; 5%), placental abruption (60; 3%), and narrow pelvis (34; 1.4%). Most often (23%) CS was performed in patients with CS scars. Conclusion. The most important step towards reducing the proportion of CS is the change of the approaches to the use of labour induction methods and assessment of the fetus condition. It is extremely important to develop a comprehensive strategy for choosing an optimal delivery method in women with post-CS scars, as well as to perform thorough analysis of the indications for planned and emergency CS. Key words: caesarean section, Robson classification, efficiency coefficient
Optimization of methods for correcting disorders of vaginal normocenosis in the primary treatment of patients
Authors:   Kuban State Medical University, Krasnodar, Russian Federation, Karakhalis L.Yu. ,   Regional Clinical Hospital No 2, Krasnodar, Russian Federation, Filipovich A.V. ,   Kuban State Medical University, Krasnodar, Russian Federation, Khalafyan A.A. ,   Kuban State University, Krasnodar, Russian Federation
Published: July 2021

Objective. To study the efficacy and feasibility of using dequalinium chloride during the primary treatment of patients of reproductive age with the symptoms of disorders of vaginal normocenosis. Patients and methods. In 60 patients of reproductive age (31.43 ± 6.44 years), an observational study was conducted, in which the initial data characterizing the state of vaginal microbiota were evaluated, and also the dynamics of their change immediately after treatment and after one month were presented. The analysis of risk factors for vaginal normocenosis disorders and dynamics of changes in the clinical picture amid dequalinium chloride therapy (Fluomizin®) was performed. Results. Significant risk factors for disorders of vaginal normocenosis are: early sexual activity (28.3%), the number of sexual partners (4.32 ± 4.11), their frequent change (13.33%), which determine hormonal and immune changes in the mucosa against the background of endocrine pathology (hypothyroidism in 8.33%) and genital endometriosis (in 35.0%). The prescription of Fluomizin® led to the relief of symptoms (itching, burning, discomfort, discharge and hyperemia) after 6 days of its use, which is confirmed by the data of the study (vaginal swabs, Femoflor 16). Conclusion. Dequalinium chloride (Fluomizin®) can be used to correct the disorders of vaginal normocenosis in the initial treatment of patients before obtaining the results of laboratory studies. Key words: reproductive period, vaginal health, dequalinium chloride, treatment quality
As ações afirmativas no Supremo Tribunal Federal: conexões entre direito e política na difícil promoção da equidade racial no Brasil
Authors: Bucci Maria Paula Dallari
Published: July 2021

Este artigo expõe o processo de aprovação das ações afirmativas para acesso às universidades do país com base no critério racial, segundo perspectiva distinta daquela mais usual na análise de decisões judiciais. Procura-se evidenciar os elementos políticos que foram se estabelecendo no período que antecede a decisão da ADPF 186, o leading case no STF, em que se reconheceu a constitucionalidade das cotas adotadas na Universidade de Brasília. Demonstram-se as conexões entre esses elementos, presentes em diversas leis aprovadas pelo Legislativo à época, bem como as nomeações de Ministros do STF, entre os quais havia doutrinadores sobre as ações afirmativas, e a argumentação jurídica desenvolvida no acórdão. Exploram-se ainda distinções entre as ações afirmativas nos EUA e no Brasil, considerando que aquele modelo serviu de inspiração ao Brasil, embora não goze da mesma aceitação do passado. Essas conexões de sentido possibilitam uma leitura mais aprofundada do significado jurídico-institucional da aprovação das cotas raciais para a mitigação de desigualdades no acesso à educação superior no Brasil, explicitando como embates políticos travados no âmbito das instituições e por meio de seu funcionamento regular são decisivos para o avanço na provisão de direitos, em paralelo com as demandas do movimento social.
PENYIMPANAN BIJI SORGUM BELUM DISOSOH DENGAN KEMASAN PLASTIK PADA BEBERAPA EKSTRAK BAHAN ALAMI
Authors: Arif Abdullah Bin , Sasmitaloka Kirana Sanggrami , Banurea Imia Ribka , Diyono Wahyu , Budiyanto Agus , Winarti Christina
Published: July 2021

Sorgum merupakan salah satu komoditas serealia yang potensial untuk dikembangkan. Namun, biji sorgum mudah terserang kutu sehingga tidak dapat disimpan dalam waktu yang lama. Serangan kutu dapat menyebabkan kerusakan dan kehilangan hasil pada sorgum. Penelitian ini bertujuan untuk mendapatkan bahan-bahan ekstrak nabati dan kemasan plastik yang dapat mudah didapatkan oleh petani dengan harganya murah untuk memperpanjang penyimpanan biji sorgum sebelum disosoh. Penelitian menggunakan rancangan acak lengkap dalam pola faktorial, terdiri dari dua faktor, yaitu jenis kemasan plastik sebanyak (PE dan PP) dan jenis ekstrak nabati (tanpa perlakuan, bawang putih, cabai, cengkeh, kayu manis, ketumbar, kopi, lada, lengkuas, dan ragi tape). Setiap perlakuan diulang sebanyak 2 kali. Variabel pengamatan pada penelitian ini adalah jumlah kutu, susut bobot, densitas kamba, proksimat, kadar pati, kadar amilosa, dan kadar amilopektin. Hasil penelitian menunjukkan bahwa perlakuan penyimpanan biji sorgum yang belum disosoh dengan plastik PP dan ekstrak cengkeh dapat mencegah terjadinya serangan kutu/Sitophilus SP yang ditunjukkan dengan jumlah populasi kutu yang paling kecil, susut bobot yang terendah, susut karbohidrat terendah, dan kadar air yang terkecil.
КАТЕГОРИЯ «СОЦИАЛЬНЫЙ КЛАСС» В КОНТЕКСТЕ ПОЛИТИКОЭКОНОМИЧЕСКОГО НАСЛЕДИЯ П.А. СОРОКИНА И Л.Н. ГУМИЛЕВА
Authors: СОЛОДОВНИКОВ С.
Published: July 2021

В контексте политико-экономического наследия П.А. Сорокина и Л.Н. Гумилева рассмотрены социально-классовые отношения как постоянно развивающиеся социально-экономические процессы. Это позволило: 1) показать, что элементами социально-классовой структуры являются социально-классовые отношения и реальные субъекты; 2) обосновать существование многообразия форм социально-классовых образований; 3) уточнить понятие «социальный класс» и ввести в оборот категории «класс-слой», «класс-сословие», «социально-классовая группа», «дистрахо-класс», «маргинальная социально-классовая группа», «синкретичный класс», «кастовая социально-классовая группа», которые фиксируют определенную стадию развития социально-классовой общности.
СИСТЕМНАЯ КОНФИГУРАЦИЯ БЕЛОРУССКОЙ ЭКОНОМИЧЕСКОЙ МОДЕЛИ
Authors: ВАСЮЧЕНОК Л.
Published: July 2021

Статья посвящена исследованию конфигурации белорусской экономической модели. Показано, что национальная экономическая модель – это способ производства и распределения рент, поддерживающий единство партнерской организации наиболее влиятельных субъектов (элиты) и служащий эталоном для воспроизведения всеми участниками экономических отношений в стране. Сформулирован принцип извлечения ренты в белорусской экономической модели: увеличение физического объема производства при частичном возмещении издержек использования видов капитала, не имеющих в республике альтернативной денежной оценки. Аргументирована функциональность модели, которая, несмотря на всю ограниченность, обеспечивает поддержание устойчивых структурных параметров белоруской экономики.
ПЕРЕХОДНЫЙ ПЕРИОД В КОНТЕКСТЕ ИНСТИТУЦИОНАЛЬНОЙ ДИНАМИКИ
Authors: ЛЕМЕЩЕНКО П.
Published: July 2021

Раскрывается содержания понятия «переходный период», которое стало наиболее употребляемым как в научной литературе, так и в обыденной жизни, но наиболее непонятным и загадочным явлением. Ставится задача также проследить через призму изменения институтов некоторые закономерности, которые присущи трансформационным процессам, формирующим тот или иной потенциал к социально-экономическому развитию, росту.
КРИЗИС ПОЛИТИКО-ЭКОНОМИЧЕСКОЙ МЫСЛИ И ПОИСК ОТПРАВНЫХ ТОЧЕК ВЫХОДА ИЗ НЕГО
Authors: АДАМОВИЧ Т.
Published: July 2021

В статье на фоне кризиса политико-экономической мысли и поиска отправных точек выхода из него рассматривается одна из сторон научного наследия профессора С.Е. Янченко в области политической экономии. В частности, анализируются идеи его фундаментального труда «Налог с оборота» и возможность их адаптации к условиям современного народного хозяйства Беларуси.
Preparation Nanoparticles of β-cyclodextrin Loaded Scutellarein Anti-tumor Activity Research by Targeting Integrin αvβ3
Authors: WANG JUNDONG , LI TIANHAO , YUE CHAOCHI , ZHONG SEN , YANG XIANGDONG , LI JUN , LI YUANZHI
Published: July 2021

The authors have requested that this preprint be removed from Research Square.
Factors Associated With Protection of Last Live Birth Against Neonatal Tetanus Among Mother Age 15-49 in Ethiopia: A Multilevel Analysis Using EDHS 2016
Authors: Kalayu Gebrezgiher , Fisseha Girmatsion , Shamie Reda , Berhe Awtachew , Embaye Kebede
Published: July 2021

Background: Neonatal tetanus is still the major public health problem in about 25 countries, mainly in Africa. Ethiopia has the highest neonatal tetanus mortality and morbidity rates in the world due to low TT immunization coverage coupled with the high amount of deliveries taking place at home. In Ethiopia, only 49% of the pregnant mothers received TT2+ in 2016. Objective: The objective of this study is to identify individual and community level factors associated with protections of last live birth against neonatal tetanus among mothers 15-49 years age in Ethiopia, evidence from Ethiopia Demographic and Health Survey 2016. Methods: The data for this study was obtained from Ethiopia Demographic and Health Survey of 2016. Population based cross-sectional study was conducted. The data were analyzed using Stata version 14. Variables that were significant in the bivariate multilevel logistic regression analysis were entered to the final model. Variables with p-value of less than 0.05 in the final model were considered as statistically significant. Interclass correlation coefficient and proportional change in variance were used to quantify the magnitude of the general contextual effect. Receiver operating characteristics curve was used to assess general accuracy of the model. Relative goodness-of-fit test was conducted using akaike’s information criterion.Results: This study depicted that, a total of 7193 women nested in 643 clusters were included in the analysis. The odds of protection of last live birth against neonatal tetanus were 1.27 and 1.53 times higher in mothers with poorer and richer respectively than mothers with poorest wealth index. Mothers who had antenatal care visit one and above had 12.3 times higher odds of protections of neonatal tetanus than those who had no antenatal care visits. The other significantly associated factors were place of delivery, region and community media exposure.Conclusion and recommendation: It can be concluded from the current study that protection of last live birth against neonatal tetanus is affected both by the individual and community level factors. Therefore, efforts to increase protection of last live birth against neonatal tetanus need to target both at individual and community level factors.
Ex-Vivo Analysis Platforms for Amyloid Precursor Protein Cleavage.
Authors: Kamikubo Yuji , Jin Hao , Niisato Kazue , Hashimoto Yoshie , Takasugi Nobumasa , Sakurai Takashi
Published: July 2021

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder and the most common cause of dementia in the elderly. Large numbers of senile plaques, neurofibrillary tangles, and cerebral atrophy are characteristic features of AD. The main component of senile plaques is amyloid β peptide (Aβ), derive from the amyloid precursor protein (APP). AD has been extensively studied using cell line, primary culture of neural cells, and animal models, however, some discrepancy is observed in these results. Dissociated cultures have lost the tissue architecture of the brain including neural circuits, glial cells, and the extracellular matrix. Animal models require lengthy animal experiments and laborious monitoring of multiple parameters following manipulations. Therefore, it is necessary to connect these experimental models to understand the pathology of AD. In order to analyze long-term neuronal development and plasticity, and progressive neurodegenerative disease, experimental platform amenable to continuous observation and experimental manipulation is required. In this report, we provide a practical method to slice and cultivate rodent hippocampus to consecutively investigate the cleavage of APP and the secretion of Aβ as an ex vivo model.
Systemic Analysis of the Dna Replication Regulators Origin Recognition Complex in Lung Adenocarcinomas Identifies Prognostic and Expression Significance
Authors: Deng Yun-bo , Chen Juan , Luo Xian-yu , Zeng Tian , Ye Dong-mei , Li Yu-kun , Tang Min , Zhang Yu-ping
Published: July 2021

Background: Origin recognition complex (ORC) 1, ORC2, ORC3, ORC4, ORC5 and ORC6, form a replication-initiator complex to mediate DNA replication, which play a key role in carcinogenesis, while their role in lung adenocarcinomas (LUAD) remains poorly understood.Methods: We confirmed the transcriptional and post-transcriptional levels, DNA alteration, DNA methylation, miRNA network, protein structure, PPI network, functional enrichment, immune infiltration and prognostic value of ORCs in LUAD based on Oncomine, GEPIA, HPA, cBioportal, TCGA, GeneMANIA, Metascape, KM-plot, GENT2, and TIMER database. Results: ORC mRNA and protein were both enhanced obviously based on Oncomine, Ualcan, GEPIA, TCGA and HPA database. Furthermore, ORC1 and ORC6 have significant prognostic values for LUAD patients based on GEPIA database. Protein structure, PPI network, functional enrichment and immune infiltration analysis indicated that ORC complex cooperatively accelerate the LUAD development by promoting DNA replication, cellular senescence and metabolic process. Conclusion: the ORC complex has an important prognostic and expression significance for LUAD patients.
Identification and Evaluation of an Appropriate Housekeeping Gene for Real-Time Gene Profiling of Hepatocellular Carcinoma Cells Cultured in Three-Dimensional Scaffold
Authors: Badekila Anjana Kaveri , Rai Praveen , Kini Sudarshan
Published: July 2021

Assessing an optimal reference gene as an internal control for target gene normalization is important during quantitative real time polymerase chain reaction (RT-qPCR) of three-dimensional cell culture. Especially, gene profiling of cancer cells under a complex 3D microenvironment in a polymer scaffold provides a deeper understanding of recapitulation of in vivo tumors. In this aspect, expression of six housekeeping genes (HKG’s): glyceraldehyde-3-phosphodehydrogenase (GAPDH), β-actin (ACTB), beta-2-microglobulin (B2M), 18S ribosomal RNA (18S rRNA), peptidyl-propyl-isomerase A (PPIA), and ribosomal protein L13 (RPL-13)) during the monolayer culture (two-dimensional), and alginate-carboxymethylcellulose scaffold based three-dimensional (3D) cell culture conditioned up to 21 days was analysed for hepatocellular carcinoma (Huh-7) cell line. The real-time gene expression using RT-qPCR of HCC spheroids in 3D culture were analyzed by determining the primer efficiency, melting curve and quantification cycle analysis of the selected candidate HKG’s. Further, RT-qPCR data were validated using analysis softwares i.e., geNorm and NormFinder for statistical significance. The study indicated RPL-13, 18S rRNA and B2M to be stable among selected referral HKG candidates and considered them as potential internal controls during varying cell culture conditions.
Diagnostic value of LncRNAs for Postoperative Metastasis of Breast Cancer: A Nested Case-Control Study.
Authors: Hao Liyue , li xiabin , Tao zhonghua , Zheng haisan , wu bin , jiang dengyong , Yang Yongxin , Tang Yan
Published: July 2021

Background: Breast cancer is an aggressive tumor with no definitely identified prognostic biomarker for diagnosis. Studies have preliminarily found that lncRNAs are closely related to breast cancer metastasis, but, the significant clinical prediction of lncRNAs was remain unclear. In this study, we evaluated the diagnostic value of long non-coding RNA (lncRNA UCA1,CCAT2, ANCR) on postoperative metastasis of breast cancer as well as the possible mechanism involving the EMT.Methods: We investigated lncRNA ANCR, UCA1,CCAT2 are at high stake of breast cancer metastasis in a population-based nested case-control study. Metastasis cases were identified by clinical diagnostic criteria in approximately 103 cases in the Cancer Institute of Southwest Medical University during 2013-2020. Meanwhile, the control group (no-metastasis) was single out on the basis of the 1:1 pairing principle in this cohort (n=103, the matching condition was the surgery time within the same month, and the treatment plan both are modifed radical mastectomy ,age±3 years) The mRNA of lncRNA( UCA1,CCAT2, ANCR) expression was determined by Real-time PCR. By Western blot, the expression of E-cadherin, N-cadherin, and vimentin proteins was detected. The migration and invasion of transfected cells were determined by the Transwell assay.Results: lncRNA ANCR,UCA1,CCAT2 was significantly up-regulated in breast cancer cells and postoperative metastasis of breast cancer.CCAT2 (OR=1.024, 95% CI:1.010, 1.039), UCA1(OR=1.025, 95% CI: 1.011, 1.039),ANCR(OR=1.055, 95% CI:1.001, 1.111)was the risk factor for postoperative metastasis of breast cancer. Further more , By the ROC curve assay, we detect the optimal critical values of CCAT2, UCA1, ANCR , the risk of metastasis in the CCAT2 high expression group was 2.297 times that of the low expression group (OR=2.297, 95% CI:1.427 ~ 3.695, P< 0.05). The risk of metastasis in the UCA1 high expression group was 2.032 times that of the low expression group (OR=2.032, 95% CI 1.282 ~ 3.218, P<0.05). We further observed that lncRNA UCA1, CCAT2, ANCR was down-regulated in MDA-231 cells by 48 h of siRNA transfection. LncRNAs UCA1, CCAT2, ANCR silencing significantly decreased the migration and invasion cells, down-regulated N-cadherin, and up-regulated E-cadherin and vimentin in MDA-231 cells.Conclusions: Our data suggested that lncRNA CCAT2 ,UCA1,ANCR was a novel molecule involved in postoperative metastasis of breast cancer, which has predictive value in patients with breast cancer metastasis.
Investigation On A Bio-Sensor: A Theoretical Study On Modified Photonic Crystal Fiber Using Plasmonic Nanomaterial
Authors: Fakhri Makram A. , Ali Hiyam S. , Salim Evan T. , Khalifa Zeina , Hashim Uda
Published: July 2021

A modified (HC-800) Photonic Crystal Fiber (PCF) using Gold nanoparticle as an active plasmonic material was used as bio a sensor. The Finite Element Method is used to compute numerical interpretations of sensing performance employing various liquids such as (Liver Blood, Colon Blood, Human Blood Plasma, Water, and Pentanol). In the proposed biosensor the sample (analyte material) is placed into a core, cladding air holes, and outside of the HC fiber structure. The sensitivity was calculated before and after adding the gold layer. The maximum amplitude sensitivity was found to be 769.5749 RIU-1 for Human blood Plasma and the best electric field was found to be 400V/m. In the same liquid when used the deposited PCF with a gold layer the maximum amplitude sensitivity was found to be 975.5352 RIU-1 at a best electric field of 477 V/m. And when the proposed sensor is considered as a refractive index sensor, where is it used the analyte samples only (inside the core and air holes) of PCF. The maximum amplitude sensitivity was found to be 869.8453 RIU-1 at a best electric field of 434 V/m.