bluuebunny/crossref_metadata_2025 huggingface dataset:
Myocardial Disease and Ventricullar Arrhythmia in Marfan Syndrome – A Prospective Study
Authors: Mosquera Laura Muino , De Wilde Hans , Devos Daniel , Babin Danilo , Jordaens Luc , Demolder Anthony , De Groote Katya , De Wolf Daniel , De Backer Julie
Published: June 2020

Background: Aortic root dilatation and -dissection and mitral valve prolapse are established cardiovascular manifestations in Marfan syndrome (MFS). Heart failure and arrhythmic sudden cardiac death have emerged as additional causes of morbidity and mortality. Methods: To characterize myocardial dysfunction and arrhythmia in MFS we conducted a prospective longitudinal case-control study including 86 patients with MFS (55.8% women, mean age 36.3yr - range 13-70yr-) and 40 age- and sex-matched healthy controls. Cardiac ultrasound, resting and ambulatory ECG (AECG) and NT-proBNP measurements were performed in all subjects at baseline. Additionally, patients with MFS underwent 2 extra evaluations during 30±7months follow-up. To study primary versus secondary myocardial involvement, patients with MFS were divided in 2 groups: without previous surgery and normal/mild valvular function (MFS-1; N=55) and with previous surgery or valvular dysfunction (MFS-2; N=31). Results: Compared to controls, patients in MFS-1 showed mild myocardial disease reflected in a larger left ventricular end-diastolic diameter (LVEDD), lower TAPSE and higher amount of (supra) ventricular extrasystoles ((S)VES). Patients in MFS-2 were more severely affected. Seven patients (five in MFS-2) presented decreased LV ejection fraction. Twenty patients (twelve in MFS-2) had non-sustained ventricular tachycardia (NSVT) in at least one AECG. Larger LVEDD and higher amount of VES were independently associated with NSVT. Conclusion: Our study shows mild but significant myocardial involvement in patients with MFS. Patients with previous surgery or valvular dysfunction are more severely affected. Myocardial function should be evaluated in all patients with MFS, especially those with valvular disease and cardiac surgery.
Preoperative endoscopic biliary stenting before pancreatico duodenectomy: Does timing matter?
Authors: Bhatti Abu Bakar Hafeez , Jafri Roshni Zahra , Khan M Kashif , Dar Faisal Saud
Published: June 2020

BackgroundRole of preoperative biliary stenting (PBS) before pancreaticodoudenectomy (PD) in patients with obstructive jaundice is debatable. The objective of the current study was to assess outcomes after PD in patients who underwent upfront surgery or PBS and determine the impact of stent to surgery duration on outcomes after PD. Methods We reviewed 147 patients who underwent PD between 2011 and 2019. Patients were grouped based on whether they underwent upfront surgery (N=76) or PBS (N=71). We further assessed outcomes based on stent to surgery interval < 4 weeks or > 4 weeks. We looked at 30 and 90 day morbidity and mortality rates in these patients.Results A significant increase in wound infections (7% vs 25%)(P=0.003), overall infectious complications (22.5% vs 38.1%)(P=0.04), re admissions (0 vs 10.5%)(P=0.005) and hospital stay (9 vs 10 days)(P=0.006) was seen in the PBS group. There was no significant difference in 30 day mortality (2.8 % vs 6.5%)(P=0.4). When compared with upfront surgery group, patients with stent to surgery duration > 4 weeks had higher rates of wound infection (7% vs 29%)(P=0.009), sepsis (11.2% vs 29%)(P=0.02), overall infectious complications (22.5% vs 45.1%)(P=0.02), re admissions (0 vs 12.9%) (P=0.007) and hospital stay (9 vs 10 days)(P=0.03). The lowest rate of infectious complications was seen when PD was performed within 2 weeks (22.2%) or 6-8 weeks (12.5%) after stenting. None of the patients with stent-surgery duration < 2 weeks developed sepsis. ConclusionsPBS appears to increase infection related morbidity after PD. In patients with PBS, low morbidity is seen with early (< 2 weeks) and delayed PD (6-8weeks).
Adaptation and convergence in circadian-related genes in Iberian freshwater fish
Authors: Moreno João M , Jesus Tiago F , Sousa Vitor C , Coelho Maria M
Published: June 2020

BackgroundThe circadian clock is a biological timing system that improves the ability of organisms to deal with environmental fluctuations. At the molecular level it consists of a network of transcription-translation feedback loops, involving genes that activate (bmal and clock – positive loop) and repress expression (cryptochrome (cry) and period (per) – negative loop). This is regulated by daily alternations of light but can also be affected by temperature. Fish, as ectothermic, depend on the environmental temperature and thus are good models to study its integration within the circadian system. Here, we studied the molecular evolution of circadian genes in four Squalius freshwater fish species, distributed across Western Iberian rivers affected by two climatic types with different environmental conditions (e.g. light and temperature). S. carolitertii and S. pyrenaicus inhabit the colder northern region under Atlantic climate type, while S. torgalensis, S. aradensis and some populations of S. pyrenaicus inhabit the warmer southern region affected by summer droughts, under Mediterranean climate type. ResultsWe identified 16 circadian-core genes in the Squalius species using a comparative transcriptomics approach. We detected evidence of positive selection in nine of these genes using methods based on dN/dS. Positive selection was mainly found in cry and per genes of the negative loop of the cycle, with 11 putatively adaptive substitutions mostly located on protein domains. Evidence for positive selection is predominant in southern populations affected by the Mediterranean climate type. By predicting protein features we found that changes at sites under positive selection can impact protein thermostability by changing their aliphatic index and isoelectric point. Additionally, in nine genes, the phylogenetic clustering of species that belong to different clades but inhabit southern basins with similar environmental conditions indicated evolutionary convergence.ConclusionsOur results support that temperature may be a strong selective pressure driving the evolution of genes involved in the circadian system. By integrating sequence-based functional protein prediction with dN/dS-based methods to detect selection we also uncovered adaptive convergence in the southern populations, probably related to their similar thermal conditions.
The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population
Authors: Wu Heming , Huang Qingyan , Yu Zhikang , Wu Hailing , Zhong Zhixiong
Published: June 2020

Background: Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) are involved in regulating lipid metabolism. However, the relation between genetic polymorphisms of APOE and SLCO1B1 and cerebral infarction (CI) remains unclear.Methods: A total of 945 CI patients and 1,028 control participants were included in the study. The single nucleotide polymorphisms (SNPs) rs429358, rs7412 of APOE gene and SNPs rs2306283, rs4149056 of SLCO1B1 gene were analyzed by fluorescence polymerase chain reaction (PCR) method.Results: The genotype ɛ3/ɛ3 is the most common genotype of APOE gene, in which ɛ3 is the allele with greatest frequency, followed by ɛ4 and ɛ2. There were statistically significant differences of genotype ɛ2/ɛ2 (c2=4.718, P=0.030), ɛ2/ɛ3 (c2=18.076, P<0.001), ɛ3/ɛ4 (c2=18.714, P<0.001), ɛ4/ɛ4 (c2=4.710, P=0.046) in CI patients comparing with controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b have greatest frequency in the study sample. There was no statistically significant difference in frequencies of SLCO1B1 genotypes and haplotypes in CI patients comparing with controls. Moreover, the ε4 carriers had significantly higher LDL-C, Apo-B, and lower Apo-A1/Apo-B than the other groups, while the ε2 carriers showed the opposite results in the CI group and controls. Logistic regression analysis indicated that participants with ε4 allele had a significantly higher risk of CI in males (OR 3.508, 95% CI 2.186-5.629, P<0.001) and females (OR 2.723, 95% CI 1.428-5.194, P=0.002).Conclusions: The study indicated that the SNPs rs429358 and rs7412 of APOE may be associated with susceptibility to cerebral infarction, in southern Chinese Hakka population.
Novel non-specific lipid-Transfer Protein (TdLTP4) isolated from Durum wheat: Antimicrobial activities to control pathogen and spoilage bacteria and Anti-Inflammatory properties in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages
Authors: Hsouna Anis Ben , Saad Rania Ben , Dhifi Wissal , Khaled Marwa , Mnif Wissem , Brini Faiçal
Published: June 2020

Background: Lipid transfer proteins (LTP) are members of the family of pathogenesis-related proteins (PR-14) that play a key role in plant defense mechanisms.Methods: In this study, a novel gene TdLTP4 encoding an antifungal protein from wheat (cv. Om Rabiaa) was subcloned, overexpressed in Escherichia coli BL-21 (DE3) and enriched using ammonium sulfate fractionation. The TdLTP4 fusion protein was then tested against a panel of pathogens, food-borne and spoilage bacteria and fungi in order to evaluate the antimicrobial properties. Our protein was applied to 0.5 µg/mL LPS-induced RAW 264.7 macrophages in vitro at different concentrations (5, 10, 20, 50 and 100 µg/ml). Levels of nitric oxide (NO), pro-inflammatory cytokines interleukin (IL)-1β (IL-1 β), interleukin (IL)-6 (IL-6), tumor necrosis factor (TNF-α) and anti-inflammatory cytokine IL-10 in the supernatant fraction were measured using enzyme-linked immunosorbent assay (ELISA). Expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were detected via Western blot. Results: The inhibition zones and minimal inhibitory concentration (MIC) values of bacterial strains were in the range of 14-26 mm and 62.5-250 µg/mL, respectively. Moreover, a remarkable activity against several fungal strains was revealed. TdLTP4 (5–100 µg/mL) decreased the production of NO (IC50= 4.32 µg/mL), IL-6 (IC50= 11.52 µg/mL), IL-1β (IC50= 7.87 µg/mL) and TNF-α (IC50 =8.66 µg/mL) by lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Our protein could modulate the macrophages inflammatory mode by causing reduction in iNOS and COX2.Conclusion: According to these findings, LTP fusion protein could be used as natural anti-inflammatory and antimicrobial agent in food preservation and human health.
Oxidized Low-Density Lipoprotein (Ox-LDL) and Malondialdehyde (MDA) and Menopause: Loss of Protective Effect of Premenopuasl Status in Type 2 Diabetes Mellitus
Authors: Arani Reyhane Hizomi , Rabizadeh Soghra , Rajab Armin , Heidari Firuzeh , Esteghamati Alireza , Mirmiranpour Hossein , Hajmiri Minoosadat , Nakhjavani manouchehr
Published: June 2020

Background: A network of factors suggested to influence oxidative modification of serum low-density lipoprotein (ox-LDL) concentrations and it plays critical role in diabetic copmlications.This study aimed to assess the joint effect of Type 2 diabetes mellitus (T2DM), gender and menopausal status on ox-LDL and Malondialdehyde (MDA) levels.Material and Method: A total of 594 female and male participants were divided into six groups: 189 postmenopausal women with T2DM, 79 premenopausal women with T2DM, 54 premenopausal women without T2DM, 53 postmenopausal women without T2DM, 186 men with T2DM and 33 men without T2DM. Laboratory and anthropometric measurements, metabolic syndrome (MetS) and the 10-year risk score for atherosclerotic cardiovascular disease (ASCVD) were assessed. Results: Ox-LDL in women with T2DM was three times higher than women without T2DM. However, ox-LDL in men with T2DM was 1.3 times higher than men without T2DM. In non-T2DM participants, postmenopausal women had higher 10-year ASCVD risk score, concentrations of ox-LDL and MDA and higher prevalence of MetS compared to premenopausal women. However, this difference disappeared in participants with T2DM. In The interaction analysis did not show an additional effect of menopausal status and T2DM for ox-LDL and MDA serum levels in female participants (respectively p= 0.310, p= 0.922). In multivariate analysis, TG was independently associated with ox-LDL concentrations (OR: 1.27, p ≤0.001). In T-test analysis, participants with MetS, higher risk of ASCVD had higher levels of ox-LDL.Conclusion: The magnitude of the increase in ox-LDL and MDA levels in women with T2DM was significantly higher than men with T2DM. The differences between pre- and postmenopausal women with and without T2DM in circulating ox-LDL and MDA mostly were dependent on T2DM, regardless of menopausal status. T2DM override the effect of menopausal status, gender and age on ox-LDL and MDA concentrations. Having MetS, increased TG levels and higher 10-year ASCVD risk score suggested to be associated with higher levels of ox-LDL.
The Risks of Advancing Parental Age on Neonatal Morbidity and Mortality are U- or J-Shaped for Both Maternal and Paternal Ages.
Authors: Thompson James
Published: June 2020

Background: The biologic implications of delayed parenthood have been blamed for a major public health crisis in the United States, that includes high rates of neonatal morbidity and mortality (NMM). The objective of this study was to evaluate the risk of parent age on NMM and to provide results that can serve as a starting point for more specific mediation modeling. Methods: Data containing approximately 15,000,000 birth records were obtained from the United States Natality database for the years 2014 to 2017. A Bayesian modeling approach was used to estimate the both the total effect and the risk adjusted for confounding between parent ages and for mediation by chromosomal disorders including Down syndrome. Outcomes included neonatal mortality and nine measures of neonatal morbidity.Results: For paternal age, seven NMM (preterm birth, very preterm birth, low Apgar score, treatment with antibiotics, treatment with surfactant, prolonged ventilation, neonatal mortality) had U-shaped risk patterns, two NMM (small for gestational age, admission to neonatal intensive care) had J-shaped risk patterns, one NMM (seizures) was not significantly related to paternal age. For maternal age, three NMM (low Apgar score, treatment with antibiotics and neonatal mortality) had U-shaped risk patterns, four NMM (preterm delivery, very preterm delivery, admission to neonatal intensive care, treatment with surfactant) had J-shaped risk patterns, one NMM (small for gestational age) had a risk declining with age, one NMM (prolonged ventilation) had a risk increasing with age and one NMM (seizures) was not significantly related to maternal age. Conclusions. Under the assumptions of a specific causal model, both advancing maternal and paternal ages had U- or J-shaped risk patterns for neonatal morbidity and mortality.
Constraining PERMANOVA and LDM to Within-Set Comparisons by Projection Improves the Efficiency of Analyses of Matched sets of Microbiome Data
Authors: Zhu Zhengyi , Satten Glen A , Mitchell Caroline , Hu Yi-Juan
Published: June 2020

Background: Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants to one or more control participants. Thus, there is a need for statistical methods for data comprised of matched sets, to test hypotheses against traits of interest (e.g., clinical outcomes or environmental factors) at the community level and/or the OTU (operational taxonomic unit) level. Optimally, these methods should accommodate complex data such as those with unequal sample sizes cross sets, confounders varying within sets, as well as continuous traits of interest. Methods: PERMANOVA is a commonly used distance-based method for testing hypotheses at the community level. We have also developed the linear decomposition model (LDM) that unifies the community-level and OTU-level tests into one framework. Here we present a new strategy that can be used with both PERMANOVA and the LDM for analyzing matched-set data. We propose to include an indicator variable for each set as covariates, so as to constrain comparisons between samples within a set, and also permute traits within each set, which can account for exchangeable sample correlations. The flexible nature of PERMANOVA and the LDM allows discrete or continuous traits or interactions to be tested, within-set confounders to be adjusted, and unbalanced data to be fully exploited. Results: Our simulations indicate that our proposed strategy outperformed alternative strategies, including the commonly-used one that utilizes restricted permutation only, in a wide range of scenarios. Using simulation, we also explored optimal designs for matched-set studies. The flexibility of PERMANOVA and the LDM for a variety of matched-set microbiome data is illustrated by the analysis of data from two real studies. Conclusions: Including set indicator variables and permuting within sets when analyzing matched-set data with PERMANOVA or the LDM is a strategy that performs well and is capable of handling the complex data structures that frequently occur in microbiome studies.
Probabilistic Tsunami Hazard Model of Building Inundation Following a Subaqueous Volcanic Explosion Based on the 1716 Tsunami Scenario in Taal Lake, Philippines
Authors: Pakoksung Kwanchai , Suppasri Anawat , Imamura Fumihiko
Published: June 2020

A probabilistic hazard analysis of a tsunami generated by a subaqueous volcanic explosion is performed for Taal Lake in the Philippines. The Taal volcano in Taal Lake is an active volcano on Luzon Island in the Philippines, and its eruption would have a strong impact on humans around the coastal area of the lake. This study aims to develop a probabilistic tsunami hazard model of inundated buildings for tsunami mitigation in future scenarios. To develop the probabilistic tsunami hazard model, different explosion diameters were used to generate tsunamis of different magnitudes in the TUNAMI-N2 model. The initial water level in the tsunami model was estimated based on the explosion energy as a function of the explosion diameter. The tsunami-induced inundation from the TUNAMI-N2 model was overlaid on the distribution of buildings. The statistical distribution of inundated buildings can be modeled with the lognormal distribution, which exhibits the best fit among nine candidate statistical distributions. The tsunami hazard analysis is explained by using the conditional hazard curve and map. These products were used to calculate the probability of building inundation given the occurrence of a subaqueous explosion. The results from this study can be used for future tsunami mitigation in the case of a tsunami generated by a subaqueous volcanic explosion.
The use of β-blockers in children in ICU – results of the interactive survey, a brief overview and own opinion
Authors: Аzovskiy D. K. , Lekmanov A. U. , Shadchnev A. P.
Published: June 2020

Many hospitals use β-blockers in adult patients, however, their use in children has not yet been determined. The objective: to collect data on the use of β-blockers in children in intensive care units (ICU). Methods: an anonymous survey containing 17 questions regarding the use of β-blockers was distributed through social networks, messengers and email. The answers were compared with published data. Results. 48 respondents provided their replies. The survey has shown that 66.7% of them use β-blockers in children while 33.3% do not. Differences in the use of β-blockers in general and pediatric ICUs are statistically insignificant. Most clinics (50%) use β-blockers in patients with congenital heart defects, followed by sepsis (18.5%). Esmolol (34.4%) is the first-line drug, followed by propranolol (31.3%). The doses ranges vary significantly (excluding esmolol). Basic monitoring and echocardiography (40.6%) are most often used to monitor the use of β-blockers. Conclusion: The survey results have shown that in Russia, the use of β-blockers in children in ICU is very limited. It is necessary to conduct big randomized, multicenter, placebo-controlled studies that will determine the effectiveness of β-blockers in children in various clinical conditions.
A Pharmacognostical Comparative Investigation on Valeriana alliariifolia Adams
Authors: ŞEN UTSUKARÇİ Burcu , CİMSİT Merve , TAŞKIN Turgut , GURDAL Bahar , BACI Oguzhan , BİLGİN Suleyman
Published: June 2020

Free radicals are shown as the main reason of many chronic and degenerative diseases. Because of the toxicity and undesirable effects of synthetic antioxidants, finding of new antioxidant natural agents is very important, especially edible plants. As an edible plant, valerian is used for various aims. Also, Valeriana species are known with their antioxidative compounds. In our previous study, some biological activities of Valeriana alliariifolia Adams roots extracts, collected in 2012, and the chemical compositions of active samples were determined. For this study, after 5 years collected plant materials were investigated again to determine and compare the antioxidant activities, the total phenolic contents and the chemical composition profile of the extracts from different plant-parts and to compare obtained results with the previous data. While RWI, RWM1 and RWM1residue were found most active by DPPH method and AHM1 by FRAP method, REM1 showed the highest activity by CUPRAC method. The high activity of AHM1 is parallel to its phenolic content. It can be thought that the difference between the results of our two studies, is due to the change of plant content from year to year and various environmental factors. This is important for achieving standardization in the production of its preparations.
A methodology for highlighting nodes in graphs applied to the analysis of financial intelligence reports
Authors: Zaina Roberto , Araujo Gustavo Medeiros de , Ramos Vinicius Faria Culmant
Published: June 2020

Money laundering is a category of crime that requires great efforts by criminal investigators to gather a variety of information in order to set the context for an investigation. One of the sources for starting the investigation and the search for adjacent information is the Financial Intelligence Report. From this report, the researcher dives into a large set of data and information to form the panorama of the investigation. With all the information gathered and interconnected, a graph is obtained in which one can use computational techniques to search for and highlight the main ones involved in the report. Since the size of the graph and the number of nodes can take on large proportions, which would make it difficult to identify the main people, companies and financial operations, this work presents as a 2 Zaina, Roberto; Araujo*, Gustavo Medeiros de; Ramos, Vinicius Faria Culmant (2020). Uma metodologia para destaque de nós em grafos aplicada à análise de relatórios de inteligência financeira (preprint). Ciência da Informação. Disponibilizado em EmeRI - Emerging Research Information. (preprints.ibict.br) DOI: 10.21452/15188353202000002. proposal, a methodology supported by technology to highlight the main ones involved in the investigation. The methodology adopted was data mining guided by metrics such as "suspicious companies" and "suspicious accountants". With the result of the data mining, a link analysis program was loaded forming the graph with the information from the highlighted nodes, representing the main ones involved in the investigation. This methodology helps the criminal investigator, as it facilitates the processing of large volumes of data and helps to decrease the complexity of the information arising from the Financial Intelligence Reports.
Review of imaging-based measurement techniques for free surface flows involving sediment transport and morphological changes
Authors: Soares-Frazão Sandra
Published: June 2020

In order to validate the numerical methods aimed at the simulation of fast transient flows involving sediment transport and morphological changes, data are required. However, field data are scarce, or, if existing, are often inaccurate or incomplete, due to the difficulty of taking reliable measurements in such difficult flow conditions. Laboratory experiments constitute a good alternative to obtain validation data for numerical models. When performing simplified experiments, a limited number of well-identified flow features can be highlighted if appropriate measurements are taken. Advances in experimental techniques in the last decades have significantly enlarged the field of possible data acquisition, especially thanks to the development of non-intrusive techniques such as digital imagery. Non-intrusive techniques are of paramount importance when considering sediment transport because a measurement device interacting with the flow would also modify the observed morphological features. In this paper, several imaging-based techniques are presented for water-level and bed evolution measurements. The key features and advantages are discussed but also the drawbacks of those techniques. The discussion is illustrated by different examples that have resulted in data sets commonly used by scientists all over the world to test their numerical simulation tools.
Study of bursting events and effect of hole-size on turbulent bursts triggered by the fluid and mid-channel bar interaction
Authors: Amir Khan Md. , Sharma Nayan
Published: June 2020

Turbulent structures of flow around the mid-channel braid bar have not been adequately investigated so far. Of late, the intrinsic fluvial hydraulics associated with the formation of braided rivers interspersed with sand bars have been vital topics of research. In this paper, the findings yielded from a research foray on the aforementioned underlying processes are presented. For obtaining the requisite experimental data, the three-dimensional flow velocity components are measured with the help of acoustic Doppler velocimetry (ADV) and these velocity data are analyzed using quadrant bursting techniques. The flow characteristics are greatly affected by the presence of a mid-channel bar. The depth-averaged contours of turbulent parameters are analyzed in the present study. Herein, the hole size concept is adopted for separating the bursting events. The effect of hole size on the quadrant events is also studied. The experiments are performed for different submergence ratios. A new parameter, Bursting Index (BI), is proposed in this research to reflect a quantitative measure of the turbulent bursting effect on streambed elevation changes. The parameter BI is the ratio of the odd event occurrence probability to the even event occurrence probability. The high values of correlation coefficients signify that the BI is profoundly influenced by streambed elevation changes, which makes it an ideal parameter for analyzing scour and deposition phenomena in real-life water management projects. The prime focus on performing the experiments has been to analyze the impact of bar height on flow structure in the vicinity of the mid-channel bar.
The Radiological Evaluation of Posterior Superior Alveolar Artery by Using CBCT
Authors: Karslioglu Hazal , Çitir Mesude , Gunduz Kaan , Kasap Pelin
Published: June 2020

Background:

Evaluation of the maxillary sinus anatomy prior to sinus lift procedures is
important to avoid surgical complications due to the close anatomical relationship between the posterior
maxillary region and the maxillary sinüs.

Introduction:

In order to avoid traumatizing the posterior superior alveolar artery and to prevent perioperative
bleeding, locating the exact position of the artery is imperative before the surgical procedures.

Methods:

150 CBCT scans were evaluated. The distance from the inferior border of the PSAA to
the alveolar crest (the vertical line from the artery to the crest) and floor of the maxillary sinus, the
distance from PSAA to medial sinus wall, nasal septum, zygomatic arch, position, the distance
from the floor of maxillary üs to the alveolar crest and diameter of the PSAA were assessed. Locations
of the artery were classified.

Results:

The artery diameters were mostly ≥ 1 mm. The artery was mostly intraosseous (59.7%),
21.7% was superficial and only 18.7% was intra-sinuscular.

Conclusion:

The location of PSAA is intraosseous in most patients. The artery diameters were
mostly ≥ 1 mm and we can say that increasing the size also increases the risk of complications.
Synthesis and In Silico Studies of C-4 Substituted Coumarin Analogues as Anticancer Agents
Authors: Dandriyal Jyoti , Kaur Kamalpreet , Jaitak Vikas
Published: June 2020

Background:

Coumarin is a fused ring system and possesses the enormous capability of
targeting various receptors participating in the cancer pathway. Coumarin and its derivatives were
found to exhibit very rare toxicity and other side effects. It has been found its immense anticancer
potential depends on the nature of the group present and its pattern of substitution on the basic nucleus.

Objectives:

Synthesis of C-4 substituted coumarin derivatives and to study their molecular interactions
with ERα for the anticancer activity for Breast Cancer.

Methods:

C-4 substituted coumarins analogues (1-10) have been synthesized using conventional
heating and microwave irradiation. Using Schrodinger software, molecular modeling studies were
carried out and ADME properties of the compounds were predicted.

Results:

All the synthesized compounds have shown better G-Score (-6.87 to -8.43 kcal/mol) as
compared to the standard drug tamoxifen (-5.28kcal/mol) and auraptene (-3.89kcal/mol). Molecular
docking suggests that all compounds fit in the active site of protein as they have the same hydrophobic
pocket as standard drug tamoxifen, and have an acceptable range of ADME properties.

Conclusion:

Microwave-assisted synthesis showed better results as compared to conventional heating.
In silico studies revealed that all the compounds befit in the active site of the protein. ADME
properties showed that all compounds are in allowable limits for human oral absorption. In the future,
there is a possibility of in vitro and in vivo studies of the synthesized compounds.
Масштабный эффект при автоволновой пластической деформации
Authors: Зуев Л.Б. , Данилов В.И. , Надежкин М.В.
Published: June 2020

The relationship between the spatial parameter of the development of localized plastic flow (the length of the autowave of localized plasticity) and the length of the deformed sample is studied. In experiments conducted on polycrystalline samples from an alloy of zirconium and technically pure aluminum, the logarithmic law of the relationship of these quantities, acting at the stage of Taylor parabolic work hardening, was established.
Полностью оптический магнитометрический датчик для задач магнитоэнцефалографии и томографии сверхслабого поля
Authors: Вершовский А.К. , Пазгалев А.С. , Петренко М.В.
Published: June 2020

A version of the scheme of an atomic cesium vapour magnetometric sensor using magnetic resonance excitation by modulated radiation transverse to the magnetic field of hyperfine optical pumping is proposed and experimentally studied. It is shown that when using a cell with a volume of 0.125 cm3, the variational sensitivity of the sensor, estimated from the ratio of the steepness of the signal at the center of the magnetic resonance to the shot noise of the detecting radiation, reaches a level of less than 10 fT/Hz1/2 in the frequency band determined by the magnetic resonance line width (of the order of 800 Hz). The sensor, which does not use and does not emit resonant radio-frequency fields, is designed to operate in magnetoencephalographic complexes. Possible ways to increase the frequency response of the circuit for detecting relatively fast (~ 4.2 kHz in a field of 0.1 mT) proton magnetic moment precession signals in promising ultralow field tomography schemes are considered.
Online Conversation Monitoring to Understand the Opioid Epidemic: Epidemiological Surveillance Study
Authors: Black Joshua C , Margolin Zachary R , Olson Richard A , Dart Richard C
Published: June 2020

Background

Between 2016 and 2017, the national mortality rate involving opioids continued its escalation; opioid deaths rose from 42,249 to 47,600, bringing the public health crisis to a new height. Considering that 69% of adults in the United States use online social media sites, a resource that builds a more complete understanding of prescription drug misuse and abuse could supplement traditional surveillance instruments. The Food and Drug Administration has identified 5 key risks and consequences of opioid drugs—misuse, abuse, addiction, overdose, and death. Identifying posts that discuss these key risks could lead to novel information that is not typically captured by traditional surveillance systems.

Objective

The goal of this study was to describe the trends of online posts (frequency over time) involving abuse, misuse, addiction, overdose, and death in the United States and to describe the types of websites that host these discussions. Internet posts that mentioned fentanyl, hydrocodone, oxycodone, or oxymorphone were examined.

Methods

Posts that did not refer to personal experiences were removed, after which 3.1 million posts remained. A stratified sample of 61,000 was selected. Unstructured data were classified into 5 key risks by manually coding for key outcomes of misuse, abuse, addiction, overdose, and death. Sampling probabilities of the coded posts were used to estimate the total post volume for each key risk.

Results

Addiction and misuse were the two most commonly discussed key risks for hydrocodone, oxycodone, and oxymorphone. For fentanyl, overdose and death were the most discussed key risks. Fentanyl had the highest estimated number of misuse-, overdose-, and death-related mentions (41,808, 42,659, and 94,169, respectively). Oxycodone had the highest estimated number of abuse- and addiction-related mentions (3548 and 12,679, respectively). The estimated volume of online posts for fentanyl increased by more than 10-fold in late 2017 and 2018. The odds of discussing fentanyl overdose (odds ratios [OR] 4.32, 95% CI 2.43-7.66) and death (OR 5.05, 95% CI 3.10-8.21) were higher for social media, while the odds of discussing fentanyl abuse (OR 0.10, 95% CI 0.04-0.22) and addiction (OR 0.24, 95% CI 0.15-0.38) were higher for blogs and forums.

Conclusions

Of the 5 FDA-defined key risks, fentanyl overdose and death has dominated discussion in recent years, while discussion of oxycodone, hydrocodone, and oxymorphone has decreased. As drug-related deaths continue to increase, an understanding of the motivations, circumstances, and consequences of drug abuse would assist in developing policy responses. Furthermore, content was notably different based on media origin, and studies that exclusively use either social media sites (such as Twitter) or blogs and forums could miss important content. This study sets out sustainable, ongoing methodology for surveilling internet postings regarding these drugs.
From the 'End of History' to the 'End of Liberalism'?
Authors: Wedekind Peter
Published: June 2020

A variety of pathologies within contemporary Western political regimes question the preference for liberal democracies: they can be contradictory, have produced significant economic inequalities, corroded social fabric, and lack a claim to exceptionalism. This judgment leads critics to conclude that not only the implementation but also the very foundation of liberal principles is flawed. In opposition to Francis Fukuyama’s initial (and now revised) claim from 1989, some argue that liberalism, rather than history, has come to its end. This essay argues that there are still merits to liberal democracies that are worth preserving. Utilising arguments from classical and neoliberal traditions it is possible to claim that individualism still serves as a bulwark against the subjugation of individuals and the arbitrary divisions based on ethnicity, race, religion, or nationality. Liberal principles continue to offer an antidote to the strengthening of authoritarian tendencies, nationalistic sentiments, xenophobia and non-democratic regimes in general.
Modelo de fiabilidad y validez de la fuerza competitiva de Porter “amenaza de entrantes potenciales”: hallazgos desde el sector financiero colombiano
Authors: Niño Duran Néstor Fernando , Camelo Irma Ruth , Pulgarin Molina Sergio Andrés
Published: June 2020

El presente documento propone un modelo enfocado en validar una de las cinco fuerzas competitivas del mercado desarrolladas por Michael Porter; específicamente la fuerza denominada Amenaza de Entrantes Potenciales en la categoría de “barreras de entrada”, con el propósito de discutir desde la evidencia empírica, la pertinencia y validez actual de los fundamentos teóricos del este autor, respecto del desempeño competitivo de los meso-sectores o industrias. El modelo propuesto provee evidencia empírica de la estructuración de barreras de entrada del sector financiero colombiano, a partir de datos recolectados en el año 2015, los cuales permite adicionalmente, explorar la pertinencia puntual de cada factor conceptual en dicho sector. Para esto, se desarrolló un modelo estadístico soportado en un análisis factorial confirmatorio (AFC), para analizar la validez de cada factor propuesto y evidenciar que las variables seleccionadas para los factores (i) requisitos de capital, (ii) acceso a los canales de distribución y (iii) diferenciación del producto presentan alto grado de confiabilidad interna, mientras los factores de (i) economías de escala, (ii) costos cambiantes y (iii) política gubernamental muestran coeficientes no aceptables. Como principales hallazgos, se evidenció que el factor que mayor contribución genera al modelo es el de economías de escala, lo que demuestra que, si una entidad financiera logra superar o afectar este factor, afectaría también de forma directa los factores de diferenciación del producto, costos cambiantes y acceso a canales de distribución. El factor que menos afectaciones genera en la estructura del modelo son las políticas gubernamentales, debido a que su impacto a la estrategia competitiva puede ser más a mediano y largo plazo.
Localización de empresas usando lógica difusa: Estrategia para su posicionamiento
Authors: Flores Romero Martha Beatriz , Guerrero Dávalos Cuauhtémoc , González Santoyo Federico
Published: June 2020

Esta investigación, consiste en determinar la ubicación óptima en la certeza e incertidumbre de una empresa dedicada a la producción de derivados del aguacate en el Estado de Michoacán, para ello toma en consideración factores objetivos y subjetivos. En este estudio se usará como base la metodología propuesta por Brown y Gibsosn (1972)- (B y G), la misma es presentada en teoría clásica, además se hace el análisis en un ambiente de incertidumbre usando lógica difusa, este enfoque no se ha reportado en la literatura especializada para el tratamiento de la metodología de referencia. Para la obtención de información (datos) se incorpora a la metodología de (B y G) apoyada por un panel de 5 expertos. Los resultados obtenidos usando lógica difusa, son eficientes y eficaces, se obtiene la ubicación óptima en la comunidad de San Juan Nuevo Parangaricutiro. De lo anterior se tiene que la aplicación de (ByG) usando  números borrosos triangulares (NBT) en el estudio de localización de empresas, en el estudio se obtiene información no proporcionada de origen que es muy valiosa para fortalecer la toma de decisiones y diseño e implantación de planes estratégicos de desarrollo empresarial.
Metodología para priorizar iniciativas de tecnologías de la información sostenibles
Authors: Lamis Rivero Jose Manuel , Plasencia Soler Juan Antonio , Marrero Delgado Fernando , Nicado García Miriam
Published: June 2020

En los albores de la economía digital, la sociedad se esfuerza por cumplir los objetivos propuestos para el desarrollo sostenible y pueden ser las tecnologías de la información y las comunicaciones una de las claves para el éxito. Sin embargo, en la actualidad, no se aprovecha correctamente todo su potencial en la solución de las problemáticas asociadas a la sostenibilidad organizacional. La presente investigación propone una metodología para la priorización de iniciativas de las tecnologías y sistemas de información sostenibles en entidades tecnológicas utilizando como principal fundamento matemático el método para la Toma de Decisión Interactiva. Los resultados de la aplicación de la metodología permitieron priorizar las principales prácticas relacionadas con el uso de computadoras portátiles, la comunicación interna y externa de iniciativas para el ahorro de energía y la implementación de sistemas de administración de energía.
Impacto de la introducción del contrato futuro del maíz amarillo en la volatilidad del precio spot: evidencia del MexDer
Authors: Zavaleta Vázquez Osmar Hazael
Published: June 2020

En octubre del 2012 se introdujo el Futuro del Maíz Amarillo en el Mercado Mexicano de Derivados. Las autoridades del Sistema Financiero Mexicano esperan que: a) sea un instrumento de cobertura más apropiado para los productores mexicanos, dado que se opera en pesos y cada contrato es por 25 toneladas; b) su introducción contribuya en la disminución de la volatilidad en el mercado físico del maíz. Mediante el uso de estructuras GARCH, los resultados proporcionan evidencia robusta para afirmar que hubo una disminución en la volatilidad del precio físico del maíz amarillo, una vez que el contrato futuro fue introducido.
Pendidikan Anti Korupsi Bagi Siswa SMA di Kabupaten Maluku Tengah
Authors: Ubwarin Erwin , Salamor Yonna Betrix , Leatemia Wilshen , Salamor Anna Maria
Published: June 2020

Indonesia will get a demographic bonus in 2045 with a hundred years in the country, which means high school students, are people who will be productive and occupy strategic positions in 2045, both in government and non-government fields, what if they life in 2045 is a corrupt generation. Then the aim of this service is to carry out the tri dharma of tertiary institutions and to foster an anti-corruption culture for students. Methods of activities by doing design thinking, and socialization. The results of this dedication, the formation of students who have mental anti-corruption and become agents of reform in high school. The changes that occur are they begin to be ashamed to cheat, do not take things that do not have them, form an honesty canteen.
ENHANCING INNOVATION AND SUSTAINABILITY REGIONAL TOURISM DEVELOPMENT IN THE ERA INDUSTRY 4.0
Authors: Isdarmanto Isdarmanto , Dwiatmadja Christantius , Sunarto Hari , Abdi Antonius Suryo
Published: June 2020

This study discusses how the sustainability tourism development strategy in every regency be able to improve the social welfare of local communities. The decentralization program has given freedom and policy to enhance the role of regional tourism to be more competitive. This study is using qualitative methods to be able to explore the empiric phenomenon of deeper problems that expected to be used as a reference for the strategy development of regional tourism applied in global and digital era, which is very competitive and professional through the strategy of well structure and systematic tourism program to be effective and efficient.
FACTORS OF INFLUENCE IN CHOOSING ACCOMMODATION: A STUDY WITH REFERENCE TO MAS VILLAGE, AN ARTISTIC HERITAGE VILLAGE IN UBUD - BALI
Authors: Pertiwi Putu Ratih , Sulistyawati Agung Sri
Published: June 2020

This paper attempts to identify the factors that influence foreign tourists to choose accommodations in Mas Village – an artistic heritage village in Ubud, Bali. As the accommodations are in the village, tourists’ motive in choosing accommodation may be different from accommodations in the big cities. The research took place in Mas Village, considering this village has been experiencing a big spike in the growth of tourists accommodation, while based on the data of 2012 until 2017 – the 87 percents of the tourists who visit this village are foreign tourists. It is known that Mas Village is one of villages in Bali fundamentally identified as an artistic countryside by focusing in artistic of wood carving since 1930s. Primary data is collected from the foreign tourists as respondents who stay in accommodations in Mas Village during June 2019, then the data is analysed using Factor analysis. The result of the factor analysis shows that location emerges as the key factor that influences tourists in choosing accommodation among three others factors. Additionally, an interesting finding from the study is how local touch and security form as one factor. By understanding the influence factors, those accommodations in Mas Village will be able to develop marketing strategies that appeal to this segment of tourists and create meaningful points of differences. However, as this research is focusing in foreign tourists, the future studies concerning how domestic tourists choose their accommodation in Mas Village is highly expected, in order to compare with foreign tourists’ perspective in this research.
THE OPTIMIZATION OF EMPLOYEE PERFORMANCE IMPROVEMENT REVIEWED FROM THE PERSPECTIVES OF PERFORMANCE ALLOWANCES, WORK MOTIVATION, AND WORK DISCIPLINE IN THE LPD BANYUNING, LPD LUMBANAN, LPD PADANG BULIA, LPD SARI MEKAR
Authors: Ningsih Luh Kartika , Prastiwi Ni Luh Putu Eka Yudi , Gorda AAN Eddy Supriyadinata
Published: June 2020

The purpose of this study was to find out how to Improve Employee Performance reviewed from the Perspectives of Performance Allowances, Work Motivation, and Work Discipline in the LPD Banyuning, LPD Lumbanan, LPD Padang Bulia, LPD Sari Mekar. This study used a quantitative approach. The data analysis technique used in the structural equation model (Structural Equation Modeling-SEM) was based on variance or component based SEM, which is famously called Partial Least Square (PLS) Visual version 3.0. All relationships examined showed positive and significant results. For this reason, in its realization, the LPD Banyuning, LPD Lumbanan, LPD Padang Bulia, LPD Sari Mekar were expected to be able to improve the performance of the Employees with the Performance Allowances. The realization of employee performance, this is also the impact of the existence of Work Motivation, Performance Allowances, and Work Discipline that will have an impact on improving employee performance in the LPD Banyuning, LPD Lumbanan, LPD Padang Bulia, LPD Sari Mekar.