bluuebunny/crossref_metadata_2025 huggingface dataset:
El sector financiero español durante los últimos 125 años
Authors: Martínez Ruiz Elena , Pons María A.
Published: December 2023

En los últimos 125 años, el sistema bancario español ha experimentado grandes transformaciones. Factores como las guerras (Primera Guerra Mundial y Guerra Civil), las crisis financieras, las restricciones impuestas por la regulación financiera, el intervencionismo estatal o el propio desarrollo de la economía condicionaron su evolución desde un sistema escasamente desarrollado alrededor de 1900, hasta un sistema moderno y con un peso notable en la economía española. El artículo repasa las diferentes fases por las que atravesó esta evolución.
PENINGKATAN PERAN KADER KELUARGA UNTUK MEMOTIVASI PENINGKATAN TUGAS DAN FUNGSI KELUARGA DALAM PENCEGAHAN KOMPLIKASI DIABETES MELLITUS
Authors: Rahmad Indra , Julhana Julhana
Published: December 2023

Diabetes adalah penyakit kronis progresif yang ditandai dengan ketidakmampuan tubuh untuk memetabolisme karbohidrat, lemak, dan protein, yang menyebabkan hiperglikemia (gula darah tinggi. Menurut Federasi Diabetes Internasional, jumlah penderita diabetes di seluruh dunia adalah 366 juta). di  2011). Kelurahan Asakota merupakan kecamatan terluas di Kota Bima dengan luas wilayah 69,03 km2 dan terletak di dekat  pantai serta merupakan daerah pinggiran yang memiliki banyak masalah kesehatan, salah satunya di kecamatan Kolo. Metode yang digunakan terdiri dari dua tahap, yaitu tahap persiapan dan tahap pelaksanaan yang berlangsung selama dua hari. Pada hari pertama kader prolan memberikan penyuluhan tentang masalah DM dan mengenalkan penggunaan pemantauan gula darah mandiri, pada hari kedua kader  memberikan penyuluhan dan mempresentasikan kepada keluarga pasien DM tentang pemantauan gula darah mandiri. Hasil penelitian menunjukkan bahwa terdapat perubahan yang signifikan pada pengetahuan dan keterampilan pengelola dan keluarga pasien DM pasca pelatihan. Perubahan informasi ini disebabkan oleh penggunaan selebaran yang berisi  DM dan penggunaan pengukuran glukosa darah secara mandiri. Kerabat pasien membutuhkan informasi tentang kesehatan, salah satunya dengan  promosi kesehatan melalui media surat kabar. Kesimpulan menunjukkan bahwa pengetahuan keluarga pasien DM dan petugas kesehatan di Puskesmas mpunda meningkat setelah dilakukan penyuluhan dengan metode ceramah dan pengenalan penggunaan alat pemantauan gula darah mandiri. Kata kunci: Peran keluarga, Diabetes Mellitus
Upaya meninggkatkan hasil Belajar Matematika Peluang
Authors: NOPRI NOPRIANSYAH NOPRIANSYAH
Published: December 2023

The lack of improvement in student learning outcomes in material opportunities is a separate homework for educators. To overcome this problem, it is necessary to pursue an active learning approach using the mind mapping method. The mind mapping method is the easiest way to put information into the brain and take information out of the brain-Mind Mapping is a way of recording that is creative, effective, and will literally "map" our thoughts. To achieve this goal, the research was conducted in three cycles. The procedure in each cycle includes the stages: action planning, action implementation, observation and reflection. The effectiveness of the actions in each cycle is measured from the results of observations and tests. Data from observations and tests are then reflected to determine corrective actions in the next cycle. In the pre-cycle the students' completeness score was 24%, in the first cycle it was 52%, in the second cycle it was 64%, in the third cycle it increased to 88%. The results of this study showed an increase in the value of mastery learning outcomes from pre-cycle to cycle I by 28%, cycle I to cycle II by 12%, cycle II to cycle III by 24%. Based on the actions taken, it can be concluded that using the mind mapping method, teachers can improve student learning outcomes in class XII Multimedia at SMKN 1 Tempilang on opportunity material.

 

Belum meningkatnya hasil belajar siswa pada materi peluang merupakan pekerjaan rumah tersendiri bagi pendidik. Untuk mengatasi masalah tersebut, perlu diupayakan suatu pendekatan pembelajaran aktif dengan menggunakan metode mind mapping. Metode mind mapping merupakan cara termudah untuk menempatkan informasi ke dalam otak dan mengambil informasi ke luar dari otak-Mind Mapping adalah cara mencatat yang kreatif, efektif, dan secara harfiah akan “memetakan” pikiran-pikiran kita. Untuk mencapai tujuan tersebut, penelitian dilaksanakan dalam tiga siklus. Prosedur dalam setiap siklus mencakup tahap-tahap: perencanaan tindakan, pelaksanaan tindakan, observasi dan refleksi. Keefektifan tindakan pada setiap siklus diukur dari hasil observasi dan tes. Data hasil observasi dan tes kemudian direfleksi untuk menentukan tindakan perbaikan pada siklus berikutnya. Pada pra siklus nilai ketuntasan siswa sebesar 24%, pada siklus I sebesar 52%,  pada siklus II sebesar 64%, pada siklus III meningkat menjadi 88%. Hasil penelitian ini menunjukkan peningkatan nilai ketuntasan hasil belajar dari pra siklus ke siklus I sebesar 28%, siklus I ke siklus II sebesar 12%, siklus II ke siklus III sebesar 24%. Berdasarkan tindakan yang dilakukan, dapat disimpulkan bahwa menggunakan metode mind mapping, guru dapat meningkatkan hasil belajar siswa kelas XII Multimedia di SMKN 1 Tempilang pada materi peluang.

 

Keywords: learning outcomes, mind mapping, opportunities
Influence of Macroeconomics Factors, Profitability, and Stock Trading Volume on Stock Prices in The Years 2019-2021
Authors: Anisa Fitriani  , Febryanti Simon
Published: December 2023

The Covid-19 pandemic, which struck Indonesia in March 2020, impacted various sectors, including the capital market. The capital market, which primarily served as a source of funding for investors, was also affected. This research was designed to examine the impact of economic elements on the share prices of manufacturing sectors amidst the Covid-19. The aspects under examination  encompassed exchange rate, inflation, probability, and stock trading volume. This research employed data from all total of 171 manufacturing industry firms listed  on the Indonesia Stock Exchange (IDX) over the period from 2019 to 2021 . The research method used is a quantitative method. The total sampling technique used resulted in a sample of 59 (fifty-nine) companies that met the research criteria. The method of data analysis employed is panel data regression analysis, utilizing the Random Effect Model (REM) estimation, which is tested using Eviews 12. The findings indicate that profitability significantly influences stock prices, while exchange rate, inflation and stock trading volume do not have a significant effect on the stock prices of manufacturing companies during 2019-2021. Based on the simultaneous test result obtained, exchange rate, inflation, profitability, and stock trading volume have a significant effect on stock prices.
Ræningjarímur séra Guðmundar Erlendssonar í Felli og erlendar fréttaballöður
Authors: Sigurðardóttir Þórunn
Published: December 2023

News ballads are poems about recent events or the poets’ contemporaries that were printed on cheap paper and sold by street vendors or performed/sung in the squares and streets of towns and cities in Europe in the early modern period. This genre has not been studied in Icelandic literary history hitherto, since poems belonging to news ballads (or disaster ballads) have not been printed but only preserved in little-known manuscripts. We can see, however, from the book of poems by pastor Guðmundur Erlendsson (primarily in the manuscripts JS 232 4to and Lbs 1055 4to, preserved in the National Library of Iceland, Reykjavík) that seventeenth-century Icelandic poets knew of news ballads. Here I examine four of his poems belonging to this genre. One deals with an earthquake in Italy in 1627; the second describes the fall of the German city Magdeburg in 1631; the third describes the execution of King Charles I of England in grotesque and horrendous detail; and the fourth portrays the king himself, bidding farewell to his wife and children and to the crown. One may infer from the texts of Guðmundur’s poems that they were intended for performance and entertainment. They feature dramatic staging, an exciting plot, and a clear moral message addressed to the audience at the end. All the poems are based on real events that happened in the poet’s time; that is, natural disasters, disasters of war, and political execution. They are presumably translations of European ballads, but the poet places the events in the context of the reality of his audience in Iceland. The poems demonstrate that the genre of news ballads reached Iceland no later than the early seventeenth century, thus expanding the repertoire of early modern Icelandic poetry.
Also of note is the fact that Guðmundur Erlendsson’s Rover rhymes do not deal with ancient heroes or fictional characters from the distant past, as was the general rule for seventeenth-century rhyme cycles, but with tragic events from the poet’s own time, the so-called “Turkish Raid” of 1627. In the rhymes, the trail of the raiders is traced around the country; place names are mentioned to support the veracity of the narrative, as are the names of people assaulted or captured by the raiders. The narrative is dramatic and suspenseful, and descriptions of the pirates’ actions are presented in grotesque detail. The last rhyme contains a warning to the audience and a moral message. The terrible events happened because of the disobedience and immorality of Icelanders, and the poet urges his compatriots to obey the Lord and pray for peace in the country, just as he did in the ballads. Thus, the poet not only translated European news ballads into Icelandic, introducing the genre to his audience/readers, but he also used the genre’s characteristics and subject matter in an innovative way in a rhyme cycle on a contemporary event in Iceland. It is entirely possible that the influence of news ballads was more prevalent in Icelandic poetry of later centuries. That needs, however, further research.
Why Would I Share?
Authors: Gill Navroop
Published: December 2023

Cultures of sharing and collaboration are essential to supporting instruction practices, yet there is limited literature on how these cultures are successfully cultivated in libraries. In this paper, I explore cultures of sharing and collaboration among instruction librarians in Canadian academic libraries. I report on a series of semi-structured interviews (n=14) I conducted with librarians who support or provide information literacy at their institutions. The interview data was reviewed using a thematic analysis approach (Braun and Clark 2022) and coded in NVivo. I explore the barriers and supports to sharing and collaboration as documented in the interviews. Barriers include a) instructional silos caused by the liaison model; (b) a lack of trust in sharing one’s teaching with colleagues; (c) the lack of prioritizing instruction in institutions; and (d) limited time to engage in collaborative work. The supports for sharing and collaboration include (a) intentionally building personal relationships, (b) developing a structure for sharing, and (c) having dedicated time for collaborative work. Based on these findings, practical ways sharing and collaboration can be cultivated in libraries will be explored.
One within Many, Many within One
Authors: Cadogan Dawn , Campbell Rice Brynne , Maher Stephen , Torian Stacy
Published: December 2023

Teaching is one of the most consequential responsibilities of an academic librarian, yet many of us approach it without the training or self-awareness required to do it well. Teaching well means being willing to commit to endless, fearless exploration of pedagogical pathways, shifting social realities, and discomforting valleys within the self. These journeys enable us to define and strengthen our teacher identities. Critical LIS studies on identity frequently explore the multiplicity of librarian attitudes toward teaching or the complexity of individual librarian identities. In our study, we merged these two exploratory objectives by analyzing the dialogical interaction of an academic librarian's multiple identities in the teaching context, specifically. As academic librarians, diverse in terms of race, gender, age, and professional experience, we engaged in collaborative autoethnography to uncover and name the interlocking identities that inform our teaching endeavours. Through the lens of dialogical self theory (DST) and its concept of self positioning, we identified positions of the self that interact and negotiate with each other to facilitate or complicate the act of teaching itself.  Autoethnographic exploration deepened our understanding of our teaching selves and helped us decipher the socio-psychological scripts that hinder and empower us as educators.
Teaching Communities
Authors: Dineen Rachel , Ilett Darren , Warner Adrienne
Published: December 2023

While instruction librarians seek the most meaningful experiences for our students, sometimes we have to look beyond tradition to meet students where they are and where they feel a sense of belonging on campus. Through autoethnography we explore what it means to teach and learn with students in extracurricular communities, such as those in support programs for first-generation students and student-athletes. We reflect on how working with these communities has shaped us as teacher librarians, including our perceptions of belonging. While not always clear-cut, we argue that working with extracurricular communities brings benefits not addressed by traditional subject librarianship.
Introduction des compétences informationnelles dans un cours universitaire
Authors: Volkanova Victoria , Freiman Viktor
Published: December 2023

Depuis quelques années, les bibliothécaires de l’Université de Moncton enseignent le volet Compétences informationnelles / Recherche en bibliothèque dans un cours obligatoire d’initiation aux études universitaires, offert à toutes les personnes étudiantes de première année, premier cycle de quelques Facultés. Dans le cadre d’une étude menée en collaboration avec le Réseau des partenaires CompeTI.CA en 2016-2019, nous avons recueilli et analysé les perceptions de personnes étudiantes inscrites aux cours, ainsi que les observations des bibliothécaires qui interviennent dans l’enseignement de ces cours. Une méthodologie qualitative et inductive de théorisation ancrée adoptée par le Réseau, inscrite dans une démarche inclusive et collaborative, a permis de générer des données de recherche et des recommandations pratiques reflétant le phénomène de développement des compétences informationnelles. Nos conclusions découlent de l’analyse des données recueillies, plutôt que de théories prédéterminées.
Le modèle étudié de l’introduction des compétences informationnelles semble bénéficier les personnes étudiantes et contribuer à leur réussite universitaire. Des pistes d’optimisation de la structure pédagogique du cours, des tests de placement, ainsi que l’importance d’une approche progressive et adaptée tout au long du parcours universitaire ne sont que quelques recommandations qui ressortent de la présente étude.
En publiant cet article, nous souhaitons apporter une modeste contribution au corpus de la littérature scientifique francophone portant sur l’intégration des compétences informationnelles dans le cursus universitaire, ainsi que le rôle des bibliothécaires dans la mission de l’enseignement post-secondaire.
Turkish Consumers’ Purchase Decisions towards Erzurum Stuffed-kadayif with Protected Geographical Indication at Dessert Retailers
Authors: Topcu Yavuz
Published: December 2023

Global climate change has rapidly changed consumers’ attitude and behavior toward food products by affecting significantly their supply and demand. In this context, the study was planned to determine the main factors affecting Erzurum Stuffed-kadayif purchasing decisions of Turkish consumers. The maim material of the research was obtained from 385 households residing in Erzurum, Turkey in 2021. Exploratory Factor Analysis and Two-step Cluster Analysis were used to explore Turkish consumers’ Erzurum Stuffed-kadayif purchase decisions at its retailers. The results of the research highlighted that while consumers consuming this product at the local restaurants or buying from the retailers satisfied fairly high from hedonic quality attributes under the sensory perception, those consuming the product at the local patisseries also provided a higher hedonism satisfaction by focusing on their willingness to consume healthy food. Similarly, consumers purchasing Erzurum Stuffed-kadayif from the local manufacturer stores tried to contribute considerably to sustainable food supply and consumption with entrocentrism approach by considering emotional food perception under food safety and security making possible to consume healthy food. Consequently, it should be improved appropriate positioning and segmentation strategies according to the purchase decisions of each consumer segment, and then they should be also able to implement.
Advancing Sustainable Justice through AI-Based Case Law Analysis
Authors: Izarova Iryna , Khotynska-Nor Oksana , Prytyka Yuriy
Published: December 2023

Background: Ukraine has a unique Unified State Register of Court Decisions that publishes all court decisions in cases considered and resolved by courts in the public domain. There are more than one hundred million such documents in the register today. This provides unique opportunities for collecting, analysing, and summarising the empirical base of justice. This has the potential to form the basis for further transformation of the national model of justice. This study's impetus may have risen from the realisation that relying solely on human resources for such endeavours may present challenges.
Methods: The study is based on the hypothesis that using hardware and software to analyse large data sets of state registers of court decisions and judicial statistics data can identify persistent patterns and causes of inefficient functioning of the judicial system.
Results and Conclusions: The study led to the development of software with functionality that annotates court decision text, intended for further use in advanced Natural Language Processing algorithms. Furthermore, the study underscores the need to develop an algorithm for predicting risks and outcomes of court proceedings and a methodology for processing large amounts of data from the Unified State Register of Court Decisions. This is justified based on specific indicators of the effectiveness of dispute resolution. This article advocates for the use of machine learning algorithms as an innovative tool to generalise large data sets from court decision registers, particularly to obtain objective data on a large scale. The article also examines the prerequisites for establishing the Institute of National Judicial Practice and explores its functioning in the present stage of judicial reform.
Challenges of Legal Guarantees for the Enforcement of Arbitral Awards in International Commercial Cases
Authors: Makarenkov Oleksii , Varregoso Mesquita Lurdes
Published: December 2023

Background: The historical determinants of the appearance of international arbitration correspond to the general tendency of the complication of legal relations of highly developed civilisations, where business processes are its drivers. It is expected that a complex transnational business layered on different levels of civilisation is characterised by an increase in the probability of misunderstandings regarding the proper fulfilment of obligations, the resolution of which is referred to as international arbitration, which, by nature, is more effective than national courts. In this regard, within legal doctrine and among legal practitioners, there is an ongoing discourse on strategies to mitigate risks associated with the execution of international arbitration decisions and related issues.
Methods: The research employed a methodological toolkit encompassing formal and dialectical logic, a synergistic methodological approach. The primary method within this framework was the synergistic analysis of the transformation of formal-legal sources and the corresponding application practices. Additional methods included historical-legal, comparative-legal, formal-dogmatic methods and contextual analysis.
Results and Conclusions: Formal-legal guarantees for the execution of international arbitration decisions represent a system of requirements governing the procedural and actual actions of state- authorised persons (bodies) that ultimately lead to such execution. The basis of such guarantees is the adequacy of the subject to which the method is applied. Firstly, the arbitrators must make the decision. Secondly, this concerns a property (commercial) dispute. Thirdly and fourthly, enforcement of arbitral awards made in the territory of a State other than the State where the recognition and enforcement of such awards are sought and arising out of differences between persons, whether physical or legal. These signs follow from the corresponding specific acts of private international law. The enforceability of an arbitral award depends on the timely and appropriate actions of the parties to the contract. Even during the negotiation of a foreign economic agreement, the result of an audit of the business partner’s reliability in terms of its ability to fulfil its financial and/or other obligations properly should be obtained.
Lukion opintojen ohjaajien ja valmennuskurssitoimijoiden episteemiset kietoutumat korkeakoulutukseen hakeutumisessa
Authors: Laaksonen Linda Maria , Jokila Suvi
Published: December 2023

Tarkastelemme tässä tutkimuksessa lukion opinto-ohjausta ja yksityisiä valmennuskurssitoimijoita ja kysymme, miten opinto-ohjauksen, yksityisten toimijoiden ja korkeakoulutukseen hakeutumiseen liittyvän tiedon kietoumat rakentuvat lukioiden arjessa. Analysoimme kolmessa suomalaisessa lukiossa vuosina 2019–2021 tuotettuja etnografisia tutkimusaineistoja. Abduktiivisen analyysin keskiössä olivat kohtaamiset, joissa opinto-ohjaajat toimivat yksityisten valmennuskurssitoimijoiden kanssa osana omaa ohjaustyötään. Kuvaamme näitä kietoumia neljän erilaisen tilanteen kautta: 1) yksityisen valmennuskurssitoimijoiden vierailut lukiolla, 2) opinto-ohjaajien omat vierailut erilaisissa yksityisen valmennuskurssitoimijoiden opinto-ohjaajille kohdennetuissa tapahtumissa, 3) yksityisten valmennuskurssitoimijoiden tarjoamat materiaalit ja 4) yksityiset valmennuskurssitoimijat osana ohjaustilanteita (puheessa). Näissä kohtaamisissa opinto-ohjaajat neuvottelivat korkeakoulutukseen hakeutumiseen liittyvästä tiedosta, joka rakentuu julkisen lukiokoulutuksen rajojen yli. Opinto-ohjauksen ja yksityisten valmennuskurssitoimijoiden suhteet muodostuivat moninaisissa yhteistyöverkostoissa. Yksityisiä ja julkisia toimijoita tarkasteltaessa tulisi siirtyä yksityinen-julkinen-jaottelusta tarkastelemaan tilanteita, joissa nämä toimijat tulevat yhteen ja neuvottelevat oman toiminnan ja korkeakoulutukseen hakeutumiseen liittyvän tiedon rajoista. Tutkimus tuottaa uutta tietoa yksityisten toimijoiden, heidän tuottaman tiedon ja opinto-ohjaajien välisiin suhteisiin.
Ecclesial Online Identities during the Covid-19 Pandemic
Authors: Johnsen Elisabeth Tveito
Published: December 2023

The majority churches in Europe are paradoxically considered to be both powerful and weak religious institutions. Their complex position in secular society makes it important for them to communicate who they are to the public. The Covid-19 pandemic was a situation in which churches and other religious institutions were ‘forced’ to use digital media as a primary arena of outreach. This article investigates how three Scandinavian majority churches negotiated their ecclesial identities on Facebook during 2020, the first year of the Covid-19 pandemic. The following question is explored: did ‘online’ enactments represent their religious identities and core values in new ways to the public? The data material consists of material from the official Facebook pages of the Evangelical Lutheran Church in Denmark (the ELCD), the Church of Norway, and the Church of Sweden, as well as interviews with Facebook editors from each church. The study demonstrates how the Church of Norway and the Church of Sweden enact church practices on Facebook, while the ELCD tries not to be too ‘churchy’. Facebook emerges as a hybridized third space where Scandinavian majority churches pursue new logics and forms of meaning making to retain their position in secular societies. Overall, the churches’ online identities on Facebook are not new representations but intensified versions of their distinct offline identities as ‘folk churches’ for the whole population.
Frederik Wallenstein: Muntlighet och minne. Sagatraditionen, kulturhistorien och det kulturella minnets blinda fläck
Authors: Sävborg Daniel
Published: December 2023

Book review of Frederik Wallenstein: Muntlighet och minne. Sagatraditionen, kulturhistorien och det kulturella minnets blinda fläck. Stockholm: Stockholms universitet, 2023, 367 pp.
PENGARUH INDEPENDENSI, OBJEKTIVITAS, PENGALAMAN KERJA, KOMPETENSI, INTEGRITAS DAN SKEPTISME PROFESIONALTERHADAP KUALITAS AUDIT (STUDI DI INSPEKTORAT PROVINSI BENGKULU)
Authors: Fadli
Published: December 2023

This study aims to find empirical evidence regarding the effect of independence, objectivity, work experience, competence, integrity and professional skepticism on audit quality at the Bengkulu Provincial Inspectorate. The type of research used in this research is quantitative research. The type of data used is primary data in the form of values or scores for the answers given by respondents to the questions in the questionnaire. The sampling technique used is the saturated sample/census method.

Based on sampling through the saturated sample/census method, 46 samples of Bengkulu Province Inspectorate auditors were obtained. The data was processed through the multiple linear regression statistical test method using SPSS software version 21. The results of the study found that competence had a positive effect on audit quality. Meanwhile, independence, objectivity, work experience integrity and professional skepticism have no effect on audit quality.
Introducing the general management of glomerular disease from a pediatric perspective based on the updated KDIGO guidelines
Authors: Lim Seon Hee
Published: December 2023

In 2021, a new chapter on the general management of glomerulonephritis (GN) was added to the Kidney Disease: Improving Global Outcomes (KDIGO). It emphasizes the importance of early general management of GN for improving long-term kidney outcomes and prognosis. The chapter introduces the management of glomerular diseases in 18 subchapters. Here, kidney biopsy for the diagnosis and evaluation of kidney function and the management of complications, such as hypertension, infection, and thrombosis, are presented. Moreover, the adverse effects of glucocorticoids and immunosuppressive therapy, which are commonly used drugs for glomerular disease, are mentioned, and a guideline for drug selection is presented. Each subtheme focused on items reflecting the interpretation of the “practice points” of the expert working group are introduced. In this review of the general treatment for GN in the KDIGO guidelines, excluding pregnancy and reproductive health, we focused on and compared various references pertaining to pediatric GN management.
Comprehensive review of membranoproliferative glomerulonephritis: spotlighting the latest advances in revised classification and treatment
Authors: Kim Jeong Yeon
Published: December 2023

Membranoproliferative glomerulonephritis (MPGN) is a complex group of renal diseases characterized by a specific pattern of glomerular injury that includes thickening of the capillary wall and mesangial expansion, leading to a heterogeneous group of conditions. This review article offers a comprehensive overview of MPGN, its new classification, pathophysiology, diagnostic evaluation, and management options.
Endocrine Disruptors and Estrogens in Human Prostatic Tissue
Authors: Vitku J , Skodova T , Varausova A , Gadus L , Michnova L , Horackova L , Kolatorova L , Simkova M , Heracek J
Published: December 2023

Endocrine disruptors (EDs) are ubiquitous substances both in the environment and everyday products that interfere with the hormonal system. Growing evidence demonstrates their adverse effects on the organism, including the reproductive system and the prostate, owing to their (anti)estrogenic or antiandrogenic effects. Since EDs can interact with steroid hormone actions on-site, understanding the levels of intraprostatic EDs in conjunction with steroids may hold particular significance. The aim of this study was to develop and validate a method for determining estrogens, various groups of EDs (bisphenols, parabens, oxybenzone and nonylphenol) and phytoestrogens in their unconjugated and conjugated forms in prostate tissue by liquid chromatography-tandem mass spectrometry, and subsequently analyze 20 human prostate tissue samples. The method enabled 20 compounds to be analyzed: estrogens (estrone, estradiol, estriol), bisphenols (bisphenol A- BPA, BPS, BPF, BPAF, BPAP, BPZ, BPP), parabens (methyl-, ethyl-, propyl-, butyl-, benzyl- paraben), oxybenzone, nonylphenol and phytoestrogens (daidzein, genistein, equol) with LLOQs between 0.017-2.86 pg/mg of tissue. The most frequently detected EDs in prostate tissues were propylparaben (conjugated and unconjugated forms in 100 % of tissues), methylparaben (unconjugated in 45 % and conjugated in 100 %), ethylparaben (unconjugated in 25 % and conjugated in 100 %), BPA (unconjugated in 35 % and conjugated in 60 %) and oxybenzone (both forms in 45 %). To the best of our knowledge, this is the first study detecting EDs, phytoestrogens and estriol conjugate (E3C) in the prostate. E3C was the most abundant estrogen in prostatic tissue. This highlights the need for further explorations into estrogen metabolism within the prostate.
PLANT CHECK: POTATO LEAF DISEASE DETECTION USING CNN MODEL
Authors: Khaparde Yashasvi , Mardikar Pranjali , Pritam Jyoti , Nayak Durgeshwari ,   Bhilai Institute of Technology
Published: December 2023

Agriculture accepts a basic part by virtue of the quick improvement of the general population and extended interest in food in India. Hence, it is required to increase harvest yield. One serious cause of low collect yield is an infection brought about by microorganisms, infection, and organisms. Potatoes are a well-known vegetable to all of us. Potato cultivation has been very popular in India form the last few decades. But potato production is being hampered due to diseases like early blight and late blight which are increasing the cost of production. The objective of this research is to establish an efficient and expedited process for detecting diseases in potatoes, with the aim of boosting potato production and digitizing the existing system. Our primary aim is to diagnose potato diseases by utilizing a CNN algorithm to analyse leaf images. This study presents an automated system, based on image processing and machine learning, for the detection and classification of potato leaf diseases. Image processing emerges as the most effective approach for identifying and analysing these diseases. To conduct this analysis, our team divided more than 2000 leaf pictures of healthy and unhealthy potatoes, obtained from the Kaggle platform. We incorporated several preprepared models to accurately identify and classify healthy and diseased leaves. Through rigorous testing, the program demonstrated an impressive accuracy of 91.41%, using a 30% test data and 70% train data split. The dataset used in this study was sourced from the renowned public data repository, Kaggle, specifically the "Plant Village" dataset.
Actores sociales y gestión de la economía circular en el estado de Chihuahua, México
Authors: Córdova-Bojórquez Gustavo
Published: December 2023

The article analyzes the participation of social actors in the management of the circular economy of urban solid waste in the state of Chihuahua, Mexico. The methodologyconsistedof semi-structured interviews, virtual interactive workshops(with the implementation ofelectronic surveys), surveysof municipalgovernments representatives,and personal communications. The resultsshow thatsocial actors barely glimpse the economic, social,and environmental meaning of betting on the circular economy. The article contributesto the analysis of the circular economy paradigm asa current sustainability tool.It is concludedthat little has been studied about the circular economy in Mexico and that the participation of non-state actors has not been valued and used efficiently. The articlereflects onwhat should and can be done with solid waste in Mexico in the future.
VALIDITY OF DEVELOPMENT OF THE GAME WHO WANTS TO BE A MILLIONAIRE COLLOID IN MAN 3 BANJARMASIN
Authors: Maslianor  , Ardian Trio Wicaksono
Published: December 2023

This study aims to determine the validity of the development of educational game who wants to be a millionaire on colloidal material for class XI students of MAN 3 Banjarmasin with the data source used consists of 1 material expert who is a chemistry teacher and 1 media expert. Data sources used consisted of 1 material expert who is a chemistry teacher and 1 media expert who is a lecturer. who is a lecturer. The type of research used is Research and Development (R&D) model (Define, Design, Develop, and Disseminate). The research results showed that the material expert validation value was 74% and the media expert validation value was 79% so that the game developed could be categorized as valid.
Clinical outcomes with a novel extended depth of focus intraocular lens Tecnis Symfony
Authors: Anisimova N. S. , Anisimov S. I. , Danilchenko M. I.
Published: December 2023

Relevance. Some of the most current intraocular lenses (IOL) are lenses with an extended depth of focus. Lenses of this type allow you to reduce dependence on glasses by distributing light energy to long-range and focus at medium distance, without losing the quality of vision. Studies that analyze the results of implantation of this type of lens are few. Purpose: to evaluate the clinical outcomes of extended depth of focus (EDOF) intraocular lens (IOL) implantation. Materials and methods. Prospective randomized study enrolled 61 patients of 79 eyes (18 to 86 years) undergone uncomplicated phacoemulsifi cation with EDOF IOL Tecnis Symfony (USA) implantation. The study was conducted from November 2020 through November 2022. Uncorrected near visual acuity (UNVA); corrected near visual acuity (CNVA) and uncorrected and corrected distance visual acuity (UDVA and CDVA), monocular defocus curve and refractive outcomes were evaluated during a 3-month period. When calculating the IOL, the target spherical equivalent was –0.35 ± 0.11 D. Results. In the postoperative period 3 months, visual acuity were 0.7 or better in 82.4% UCDVA, 100% CDVA and 50% UCNVA. 3 months after surgery, UDVA and UNVA at 40 cm averaged 0.85 ± 0.15 and 0.69 ± 0.18, respectively. CDVA and CNVA at 40 cm was 0.98 ± 0.04 and 0.8 ± 0.14, respectively. A total of 85.7% of eyes achieved postoperative visual acuity about 0.5 for the range of defocus levels between +1.00 and −1.50 D. Conclusions. Cataract surgery with Tecnis Symfony EDOF IOL implantation provide functional levels of visual acuity in distance, intermediate zones. The near visual performance with this IOL might be signifi cantly enhanced using a micro-monovision approach
PENGARUH SUDUT KELENGKUNGAN INTAKE MANIFOLD TERHADAP PERFORMA MESIN SEPEDA MOTOR
Authors: Vicky Styo Pramono
Published: December 2023

In a gasoline engine, the intake manifold is an important component because the intake manifold functions as an inlet for air and fuel into the combustion chamber. The shape of the curvature of the intake manifold affects the air entering the combustion chamber. Because to produce a homogeneous mixing of air and fuel to produce perfect combustion. Of course it has an impact on the torque and power produced.Torque and power testing using a special dynotest tool. The research conducted has several variables that will affect the output of this study, namely the independent variables include variations in the angle of curvature of the manifold using standards, 140˚, 155˚, and 160˚, type of fuel with ron 90 and engine speed (RPM). The dependent variable is torque, power and fuel consumption which will be tested. The hypothesis in this study is the alternative hypothesis (H1) because according to the analysis changes in the curvature of the manifold can affect the performance of the motorcycle engine. Impact results have the greatest influence on the  power  produced,  with an  angle  of  100 ̊  indicating  superior  power  than  other intake manifolds. For Dmax (Maximum Power) right at 6500 rpm engine speed with an average of 5.86Hp. Meanwhile, the intake manifold with a curvature angle of 120 shows the best results with Tmax (Maximum Torque) at 5000 rpm engine speed with an average of 7.16nm.
MANUFACTURING SEMI AUTOMATIC HAKSAW
Authors: Nurisna Zuhri
Published: December 2023

Hacksaw is a saw that is used to cut metal objects such as iron. Hacksaws are still widely used for metal cutting processes because they have the advantage of not generating excessive heat during the cutting process which can affect the metal structure. Behind these advantages, cutting metal using a hacksaw manually is less efficient in time and the cutting results are less neat. The solution to this problem is to make a hacksaw with an electric motor drive. The design of this automatic hacksaw machine uses a drive in the form of an electric motor with a capacity of 0.5 HP. The output from the rotation of the electric motor is forwarded using pulleys and gears with a ratio of 12:1, and is continued using a slider to move the hacksaw blade back and forth. Reduction of rotation is intended to increase the cutting torque. The design of this hacksaw machine also adds a feature in the form of an automatic switch to stop the movement when the cut is complete. Based on the test results of the automatic hacksaw machine used for cutting carbon steel, the cutting capacity is 2.4 cm2/minute and the electric motor power calculation has a power capacity of 2.5 W/cm2. The results of cutting the material are also straight and neat without causing heat during the material cutting process.
Mathematical model of physicochemical regulation of precipitation of bone hydroxyapatite
Authors: Poorhemati Hossein , Komarova Svetlana V.
Published: December 2023

Introduction

Formation of hydroxyapatite in bone, dentin, and enamel occurs at restricted molecular sites of specific extracellular matrix proteins and is controlled by multiple mineralization inhibitors. However, the role of physicochemical factors, such as the availability of required ions and the saturation status of the aqueous environment in biological mineralization, is not fully understood. The goal of this study was to use mathematical modeling to describe the complex physicochemical environment permissive to the precipitation of biological hydroxyapatite.

Methods

We simulated the processes occurring in the bone interstitial fluid (ISF) defined as an aqueous environment containing seven chemical components (calcium, phosphate, carbonate, sodium, potassium, magnesium, and chloride) that form 30 chemical species. We simulated reversible equilibrium reactions among these chemical species, and calculated supersaturation for hydroxyapatite and its precipitation rate using kinetic theory.

Results and Discussion

The simulated ISF was of correct ionic strength and predicted the equilibrium component concentrations that were consistent with the experimental findings. Supersaturation of physiological ISF was ~15, which is consistent with prior findings that mineralization inhibitors are required to prevent spontaneous mineral precipitation. Only total calcium, total phosphate and to a lesser degree total carbonate affected ion availability, solution supersaturation and hydroxyapatite precipitation rate. Both calcium and phosphate levels directly affected hydroxyapatite precipitation, and phosphate was affected by pH, which additionally influenced hydroxyapatite precipitation. Integrating mathematical models capturing the physiochemical and biological factors regulating bone mineralization will allow in silico studies of complex clinical scenarios associated with alterations in ISF ion composition, such as rickets, hypophosphatemia, and chronic kidney disease.
Development of a monoclonal antibody to ITPRIPL1 for immunohistochemical diagnosis of non-small cell lung cancers: accuracy and correlation with CD8+ T cell infiltration
Authors: Deng Shouyan , Shi Jiawei , Sun Yufan , Quan Yingfei , Shen Zan , Wang Yonggang , Li Hai , Xu Jie
Published: December 2023

Introduction: Cancer biomarkers are substances or processes highly associated with the presence and progression of cancer, which are applicable for cancer screening, progression surveillance, and prognosis prediction in clinical practice. In our previous studies, we discovered that cancer cells upregulate inositol 1,4,5-triphosphate receptor-interacting protein-like 1 (ITPRIPL1), a natural CD3 ligand, to evade immune surveillance and promote tumor growth. We also developed a monoclonal ITPRIPL1 antibody with high sensitivity and specificity. Here, we explored the application of anti-ITPRIPL1 antibody for auxiliary diagnosis of non-small cell lung cancer (NSCLC).

Methods: NSCLC patient tissue samples (n = 75) were collected and stained by anti-ITPRIPL1 or anti-CD8 antibodies. After excluding the flaked samples (n = 15), we evaluated the expression by intensity (0-3) and extent (0-100%) of staining to generate an h-score for each sample. The expression status was classified into negative (h-score < 20), low-positive (20-99), and high-positive (≥ 100). We compared the h-scores between the solid cancer tissue and stroma and analyzed the correlation between the h-scores of the ITPRIPL1 and CD8 expression in situ in adjacent tissue slices.

Results: The data suggested ITPRIPL1 is widely overexpressed in NSCLC and positively correlates with tumor stages. We also found that ITPRIPL1 expression is negatively correlated with CD8 staining, which demonstrates that ITPRIPL1 overexpression is indicative of poorer immune infiltration and clinical prognosis. Therefore, we set 50 as the cutoff point of ITPRIPL1 expression H scores to differentiate normal and lung cancer tissues, which is of an excellent sensitivity and specificity score (100% within our sample collection).

Discussion: These results highlight the potential of ITPRIPL1 as a proteomic immunohistochemical NSCLC biomarker with possible advantages over the existing NSCLC biomarkers, and the ITPRIPL1 antibody can be applied for accurate diagnosis and prognosis prediction.
Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria
Authors: Pance Alena , Ng Bee L. , Mwikali Kioko , Koutsourakis Manousos , Agu Chukwuma , Rouhani Foad J. , Montandon Ruddy , Law Frances , Ponstingl Hannes , Rayner Julian C.
Published: December 2023

Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the blood. The influence of human genetic traits on malaria has been known for a long time, however understanding the role of the proteins involved is hampered by the anuclear nature of erythrocytes that makes them inaccessible to genetic tools. Here we overcome this limitation using stem cells to generate erythroid cells with an in-vitro differentiation protocol and assess parasite invasion with an adaptation of flow cytometry to detect parasite hemozoin. We combine this strategy with reprogramming of patient cells to Induced Pluripotent Stem Cells and genome editing to understand the role of key genes and human traits in malaria infection. We show that deletion of basigin ablates invasion while deletion of ATP2B4 has a minor effect and that erythroid cells from reprogrammed patient-derived HbBart α-thalassemia samples poorly support infection. The possibility to obtain patient-secific and genetically modifed erythoid cells offers an unparalleled opportunity to study the role of human genes and polymorphisms in malaria allowing preservation of the genomic background to demonstrate their function and understand their mechanisms.
Gut microbiota landscape and potential biomarker identification in female patients with systemic lupus erythematosus using machine learning
Authors: Song Wenzhu , Wu Feng , Yan Yan , Li Yaheng , Wang Qian , Hu Xueli , Li Yafeng
Published: December 2023

Objectives

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that disproportionately affects women. Early diagnosis and prevention are crucial for women’s health, and the gut microbiota has been found to be strongly associated with SLE. This study aimed to identify potential biomarkers for SLE by characterizing the gut microbiota landscape using feature selection and exploring the use of machine learning (ML) algorithms with significantly dysregulated microbiotas (SDMs) for early identification of SLE patients. Additionally, we used the SHapley Additive exPlanations (SHAP) interpretability framework to visualize the impact of SDMs on the risk of developing SLE in females.

Methods

Stool samples were collected from 54 SLE patients and 55 Negative Controls (NC) for microbiota analysis using 16S rRNA sequencing. Feature selection was performed using Elastic Net and Boruta on species-level taxonomy. Subsequently, four ML algorithms, namely logistic regression (LR), Adaptive Boosting (AdaBoost), Random Forest (RF), and eXtreme gradient boosting (XGBoost), were used to achieve early identification of SLE with SDMs. Finally, the best-performing algorithm was combined with SHAP to explore how SDMs affect the risk of developing SLE in females.

Results

Both alpha and beta diversity were found to be different in SLE group. Following feature selection, 68 and 21 microbiota were retained in Elastic Net and Boruta, respectively, with 16 microbiota overlapping between the two, i.e., SDMs for SLE. The four ML algorithms with SDMs could effectively identify SLE patients, with XGBoost performing the best, achieving Accuracy, Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value, and AUC values of 0.844, 0.750, 0.938, 0.923, 0.790, and 0.930, respectively. The SHAP interpretability framework showed a complex non-linear relationship between the relative abundance of SDMs and the risk of SLE, with Escherichia_fergusonii having the largest SHAP value.

Conclusions

This study revealed dysbiosis in the gut microbiota of female SLE patients. ML classifiers combined with SDMs can facilitate early identification of female patients with SLE, particularly XGBoost. The SHAP interpretability framework provides insight into the impact of SDMs on the risk of SLE and may inform future scientific treatment for SLE.