bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Depression, Anxiety and Stress Levels on DASS-21 Scale in Medical Students of First Year Odd and Even Batch at Miraj City - An Observational Study
Authors: Karanjkar Smrutika , Chavan Shwetambari
Published: July 2022

Background: Stress, Anxiety and Depression decrease the academic performance of the students and this plays an important role in academics. The Scale used is Depression, Anxiety and Stress Scale – 21. It is a 21 Items scale which helps to find out levels of depression, anxiety and stress in an individual. It assesses difficulty relaxing, nervous arousal, and being easily upset / agitated, irritable / over-reactive and impatient. Scores for depression, anxiety and stress are calculated by summing the scores for the relevant items.
Aim: To Prevalence of Depression, Anxiety and Stress Levels on DASS21 Scale in Medical Students of First Year Odd and Even Batch at Miraj City.
Method: The sample size comprises of 184 students of first year from Medical Courses in Miraj including both Males and females of odd (92) and even (92) batch. The outcome measures used is a Depression anxiety and stress Scale – 21 which will be given to the students and explained in a language comfortable to them. The students will then complete the scale correctly and truly. Data will be analyzed based on the scores of each student.
Outcome Measure: Depression, Anxiety and Stress Scale – 21
Result: The result proves that presence of Depression, Anxiety and Stress were seen clinically and statistically significant in intra-batches. The mean value of depression, anxiety and stress indicated mild depression in even Batch whereas moderate to severe in Odd Batch. Even batch has mild to moderate anxiety and severe to extremely severe is seen in Odd batch. Stress observed is mild to moderate in odd as well as in even batch.
Conclusion: On comparison in both batches depression is found in odd batch with significant p-value, whereas anxiety and stress do not have significant p-value hence the can be compared in terms of severity levels. The study concludes that there is more depression, anxiety and stress in odd batch than in comparison with the even batch.

Key words: Depression, Anxiety and Stress Scale – 21, First Year Odd and Even Batch Medical Students, mental health. .
A Comparative Study of Play Therapy and Child Friendly Constraint Induced Movement Therapy in Cerebral Palsy
Authors: Harini K. , Raj Gokila , Dhasaradharaman Kannan
Published: July 2022

Background: Cerebral Palsy is a neuro developmental disorder caused by non progressive lesion in the developing brain. The aim of the study was to compare the effect of constraint induced movement therapy vs play therapy in cerebral palsy.
Method: A sample of 20 patients within the age group of 4-8 years with cerebral palsy were randomly divided into two groups, Group A (n= 10) and group B (n= 10). The subjects in group A was treated with CIMT [Constraint induced movement therapy] and the subjects in group B was treated with Play therapy. The subject’s improvement on hand functions was assessed by Box and Block test (BBT) and Motor Activity Log Scale (MAL) and pre and Post test results were analysed.
Result: The study concludes that there was statistically significant improvement of hand function in group A compared to group B in response to treatment
Conclusion: Based on the result, this study concluded that child friendly constraint induced movement therapy is effective in spastic hemiplegic cerebral palsy than play therapy in cerebral palsy.

Key words: CIMT, PLAY THERAPY, BBT, MAL .
A Survey of Musculoskeletal Health in Information Technology Professionals
Authors: Tetgure Chetana , Parle Dr. Jyoti , Phadke Dr. Shweta
Published: July 2022

Introduction: India has been in the forefront in cyber world with information technology (IT) industry developing into a major service provider. Long working hours on computer, Static postures, poor office ergonomics, and repetitive nature of work were identified as some of risk factors affecting musculoskeletal health of IT workers. The Musculoskeletal Health Questionnaire (MSK-HQ) is short questionnaire that allows people with musculoskeletal conditions to report their symptoms and quality of life in a standardised way. Musculoskeletal problems if ignored can become chronic debilities hence there is need to focus on improving musculoskeletal health and quality of life.
Material: Cross section study was done on 100 IT professionals using Musculoskeletal health Questionnaire after taking permission from ethical committee and from Oxford University Innovation. Participants were clearly and deeply informed about the procedure of the study. which includes informed consent and questionnaire.
Nature and purpose of study was explained and an informed online consent was taken from each and every subject.
Hence the objective of this study is to find musculoskeletal health among information technology professionals.
Conclusions: In this study the participants were more from the younger group, in which most of the participants were experiencing pain in one or more joints and they were also not aware about the musculoskeletal conditions therefore they are not taking any treatment.
This study also reported less physical activity in information technology professionals.
There is also need to spread awareness about musculoskeletal conditions and importance of physical activity

Key words: Musculoskeletal health, IT professionals, work related risk factor.
Efficacy of Oral-Sensory-Motor Intervention in The Management for Drooling of Saliva in Children with Cerebral Palsy - A Cross-Sectional Study
Authors: Gupta Ambar , Balasubramanian Sivaranjani , Bhavsar Reshma
Published: July 2022

Purpose:Drooling of Saliva is one of the major issues that can have a serious effect on the health of those children suffering from it which is often prevalent in children with CP but seldom looked into during therapeutic intervention. Hence, we focused on treating the drooling through oral-sensory-motor intervention (oral-motor therapy + rMV) instead of a medical/surgical intervention and to also assess its efficacy as a management option.
Methodology:This is an observational study, administered on 13 children of 5 to 16 years, diagnosed with severe drooling consequent to CP. The efficacy was assessed by comparing the baseline & follow-up scores measured using the Drooling Impact Scale (Reid et al., 2010).
Result:The results showed that there was a statistically significant improvement ('t' critical=2.179; p-value ≤ 0.05) in all the 10 parameters. No statistically significant difference was observed with respect to age or type of CP.
Conclusion:The study concludes that oral-sensory-motor integration proves to be an effective management to control the drooling of saliva in children with CP. However, to understand the influence of the factors like age or type of CP, further research with larger sample size is warranted.

Key words: Cerebral Palsy; Drooling; Behavioural Integration; Sensory-motor Integration; Drooling Impact Scale; Oro-motor exercises.
Characteristics of Distal Radius Fracture Patients at
Gema Santi Nusa Penida Hospital in 2020-2021
Authors: Jaya Santika I Kadek
Published: July 2022

Introduction: Distal radius fracture is the most common fracture found in Gema Santi Nusa Penida Hospital. The incidence of distal radius fracture peaks in the paediatric who experience high energy fall which predominantly males and then the elderly population with osteoporotic bone experiencing low energy fall which predominantly females. A study is needed to determine the fracture characteristics which in this study discusses about the distal radius fracture.
Methods: This research is a retrospective study with the population was all distal radius fracture patients who were treated at Gema Santi Nusa Penida Hospital from 2020 to 2021. The research sample was collected using a total sampling technique obtained from the patient medical record of the emergency unit and general surgery clinic.
Results: Of the 44 samples obtained, the most cases of distal radius fracture were in the age range of 11-20 years with male gender caused by traffic accidents and then in the age range of 61-70 years with female gender caused by falling from a standing height.
Conclusion: Most cases in the elderly female may relate to the onset of postmenopausal osteoporosis. Cases that often occur at a young age due to traffic accidents need further policy to improve the safety of motorized vehicle drivers. Special treatment also needs to be done in osteoporotic elderly women to reduce complications that can occur due to osteoporosis such as fractures of the distal radius.

Key words: Distal radius fracture; Young; Elderly; Traffic accidents; Osteoporotic bone .
Comparative Treatment Between Total Hip Arthroplasty Versus Hemiarthroplasty for Femoral Neck Fracture in Elderly: A Systematic Review and Meta-analysis
Authors: Oka Dharmayuda Cokorda Gde , Raditya I Nyoman Yuda
Published: July 2022

Introduction: Hip fractures are leading cause of disability worldwide, with displaced femoral neck fractures being of particular concern. There’s different opinion about advantages of performing total hip arthroplasty or hemiarthroplasty, recent meta-analysis reported that total hip arthroplasty (THA) was superior to hemiarthroplasty (HA) in terms of reoperations, but inferior in terms of dislocations.
Methods: We conducted a literature search of 4 databases to identify randomized controlled trials comparing THA and HA in patients. Focus in this systematic review and meta-analysis is to compare clinical outcome between Hemiarthroplasty versus Total Hip Arthroplasty for Femoral Neck Fracture
Results: We found that there is no significant difference statistically. We found no significant difference in the functional outcome between two groups between these two groups in Functional Outcome (Harris Hip Score), EQ-5D outcome, Complication Rate Outcome and Revision Rate Outcome between Total Hip Arthroplasty versus Hemiarthroplasty for Femoral Neck Fracture in elderly.
Discussion: The choice of THA or HA in FNF in the active elderly remains uncertain, although different opinion has been reported, in our systematic review, no significant difference was found in the functional outcome between two groups measured with
Conclusion: There was no differences on functional outcome and EQ-5D between Total Hip Arthroplasty and Hemiarthroplasty on Femoral Neck Fracture in elderly

Key words: [Total Hip Arthroplasty, Hemiarthroplasty, Femoral Neck Fracture].
Effect of Socio-Cultural, Economic and Religious Factors on Type 2 Diabetes Management: Evidence from Akungba-Akoko Metropolis, Ondo State, Nigeria
Authors: Elizabeth Okeya Dr. Olutoyin
Published: July 2022

This research was conducted to examine whether socio-cultural, economic, religious and other demographic factors affect the way Type 2 Diabetes is managed among registered patients in Akungba-Akoko metropolis, Ondo State, Nigeria. In order to achieve the stated objectives, the study employed descriptive statistics to analyze responses to structured questionnaire administered to 30 Type 2 Diabetes patients registered in two health centres in the community of study. Results from percentages, charts and tables shows that socio-cultural, economic and religious factors exert much influence on the management of Type 2 Diabetes among patients registered. Other factors such as family support, age and occupation were found also have significant effect on Type 2 Diabetes management among the sample studied although some of them claim otherwise. The P values (p = 0.000) for all the factors show that the effect of these factors are all significant on T2 Diabetes management. The study advocates the need for the State Ministry of Health to organise awareness campaigns on how best to prevent T2D and how effectively existing cases of T2D can be managed. Policies tailored towards ameliorating medical expenses for T2D patients should be introduced while corporate and Non-Governmental Organisations (NGOs) should also complement the efforts of the State and Local Government to assist those diagnosed with T2D.

Keywords: Type 2 Diabetes, Socio-cultural, Economic, Religious, Demographic Factors.
Variation of Heart Rate in Patients with Snake Bite
Authors: Rajeshkumar Dr. A. , Muhil Dr. M. , Vennila G.
Published: July 2022

The HRV is the Physiological variation of Beat-to- Beat variation in heartbeat. This variation is controlled to on balance by the autonomic nervous system (sympathetic and parasympathetic). Snake bite is the most common problem in tropical and subtropical countries. Snake bite is related to highest mortality of poorly developed countries mainly the farmers suffered a lot. As per the World Health Organization’s list the snake bite is neglected tropical diseases. Immediately after the snake bite toxicity of the venom enters into circulation and affects various parts of the body. The snake venom acts on the Autonomic nervous system, and affect the heart and reduces the heart rate. The HRV is a clinical and investigational tool for assessing the cardiac performance. Analysis of Heart Rate variability is one of the non-invasive electrocardiographic markers to find out the changes HRV in snake bite patients. In snake bite envenomation the increases HRV (P-Value is <0.05) is considered as the statistically significant. We conclude that autonomic control of the heart rate measured by heart rate variability was altered on acute action of snake envenomation. Initially there was parasympathetic dominance in snake bite and treatment with antivenom lead to sympathetic dominance.

Keywords: Heart rate variability, low frequency, high frequency, envenomation.
Assessment of Knowledge and Awareness about Basics of Radiation and Safety Measures among Allied Health Science Professionals Including Radiographers and Students of Radiology and Imaging Technology: University Based Study
Authors: Jha Prashant Kumar , Thidwar Rajdeep , Yadav Piyush
Published: July 2022

Aim & Objective-This study has been undertaken to assess the knowledge and awareness about basics of radiation and safety measures in diagnostic radiology among allied health professionals including, Radiographers, and students of Radiology and imaging technology.
Materials and Methods: A questionnaire based survey was performed to collect data of knowledge about the radiation awareness and safety measures using in diagnostic radiology, among allied health professionals including radiographers, and students of Radiology and imaging technology.
Result- Knowledge about principle of radiation protection was very disappointing, because 30.60% of the participants know the basic principle of radiation protection (Justification, Optimization, and Dose Limit). 43.40% participants said that, ALARA is the basic principle of radiation protection while 26% participants said that, TDS (Time, Distance and Shielding) is the basic principle of radiation protection.
Discussion-Majority of participants needs to improve their knowledge about the radiation awareness and safety measure.

Keywords: Radiation, Safety, Protection, Radiation awareness.
Iris Melanoma: Genetic Pathway, Staging, Histopathology, Clinical Features, Diagnostic Imaging, Treatment and Management
Authors: Rehmani Areeb , Sai Charan Labishetty , Rani Tara
Published: July 2022

Introduction- Iris melanomas mainly grow in the anterior chamber or along the iris surface, and by local extension; they commonly invade the anterior chamber angle and anterior ciliary body. Iris melanomas account for 2–3% of all uveal melanomas, with the diffuse variety accounting for about 10% of all iris melanomas.
Methodology-A systematic review is a technical tool that basically describes a more or less systematic way of collecting and synthesizing past research by integrating findings and perspectives from a variety of empirical findings. In this study, authors conducted a systematic assessment of 51 research articles on the subject of "Iris Melanoma" in order to examine and compare the various approaches and outcomes.
This comprehensive review summarizes all 51 research articles in the most accessible manner to discuss the Genetic pathway, Staging, Histopathology, Clinical features, Diagnostic Imaging, Treatment, and Management.
Results-Iris melanomas are discovered early and treated fast because they are apparent when they are little. As a result, patients with this tumor had a better prognosis than those with posterior uvea tumors.
Conclusion- Radiotherapy or surgical resection are usually used in this situation. A combination of radiotherapy and surgery may be employed in some circumstances. Conservative treatment is an excellent option for enucleation since it provides for effective tumor control locally.

Keywords:melanoma, Diagnosis, Management, Stages, Eye-care.
A Review: ICDS Programmes: To Develop a New Fortified Nutrient Rich Sugar Free Supplementary Food Product
Authors: Pandya Binal , Tarpara Neha
Published: July 2022

Integrated Child Development Services (ICDS) is India's flagship programme for infant and young child health, nutrition and development. Supplementary Nutrition Programme (SNP) is one of the core components of ICDS. Balshakti (Energy Dense Micronutrient Fortified Extruded Blended Food) is provided as Take-Home Ration (THR) to children 7 months to 3 years. The feasibility of using a wheat flour mill to refine corn, soya, ragi, moong dal and chickpea was studied. Milling of wheat, ragi, rice, corn, chana dal, moong Dal, and soya grain resulted in fiber content from 1.93, 2.16,2.60 and 2.50 % in raw, finely milled and coarsely milled moong dal and ragi respectively. kcal obtain from BSR and BSM 455.66 & 435.22. Similarly, there was a fat, protein (1.74 &0.70) (25.79 &8.59) content from roasted material, according to ICDS Indian RAD for 12-23 month age group of infant have to required 1060 kcal and 16.7 g protein. our product (THR) provides 500 kcal and 12-15 g protein. aim was this new development to more nutrition and healthy food gave infant.50 % requirement fulfilled by this new product.

Keywords: ragi, moong dal, ICDS, THR, protein, nutrition, BS.
Habit of Smartphone Usage and Its Impact on Behavior among Under Five Children as Perceived by Parents
Authors: Kulkarni Prashant Baburao , Mhaske Dr. Anuradha
Published: July 2022

Background: The time that children spend using digital devices is increasing rapidly with the development of new portable and instantly accessible technology, such as smartphones and digital tablets. Although prior studies have examined the effects of traditional media on children’s development, there is limited evidence on the impact of mobile device use. The current study aimed to assess the smart phone usage habits and its impact on behavior of under five children as perceived by their parents.
Methods: A purposive sample of 40 under five children was included in the study. Structured rating scales were used for assessing the smart phone usage and its impact on behavior as perceived by the parents. Data were analyzed using the descriptive and inferential statistics.
Results: 60% of the children had moderate habit and 37.5% had poor habit of Smartphone usage. 65% of children had moderate impact of Smartphone usage on their behavior and 37.5% children had high impact of Smartphone usage on their behavior as perceived by their parents. There is a significant positive correlation between habit of Smartphone usage and behaviour scores of children (r=0.9972, p<0.001)
Conclusion: Many parents are unaware about the impact of mobile on their children. Still there is a need to conduct so many studies on impact of mobile on physical, physiological and psychological health status among children.

Keywords: Smartphone, Habit, Behavior, Under five children, Parents.
Comparison of Mulligan Bent Leg Raise (BLR) Versus Traction Straight Leg Raise (TSLR) Technique in Hamstring Tightness in Sewing Machine Operators with Low Back Pain
Authors: Bhosle Dr. Pooja , Akhter Rizvi Dr. Syed Rais
Published: July 2022

Background and Objectives: Mulligans Bent Leg Raise (BLR) and Traction Straight Leg Raise (TSLR) both have been showed improvement in hamstring flexibility. The objective of the study was to find the comparative effect of Mulligans Bent Leg Raise (BLR) over Traction Straight Leg Raise (TSLR) in hamstring tightness in sewing machine operators with low back pain.
Methods: 40 sewing machine operators with Hamstring tightness in terms of Lack Of Active knee extension test more than 200 were randomly allocated in two groups. Group A (N=11; M=8, F=9) Mulligans Bent Leg Raise Technique and Group B (N=20; M=9, F=11) received Traction Straight Leg Raise technique. The outcome was assessed in terms of hamstring flexibility by Back saver sit and reach test and disability by Oswestry Low Back Pain Disability Questionnaire at pre and post intervention.
Results: The result of present study demonstrated that Both the interventions in group-A (BLR) and group-B (TSLR) were found to be individually effective in treating sewing machine operators with hamstring tightness and low back pain in increasing BSSR in both right and left side and decreasing the disability. But, while compared the post test outcomes in between the groups, there was no much difference in between the groups.
Interpretation and Conclusion: The present study concludes that both the interventions of Mulligans BLR and TSLR were individually effective in increasing the flexibility of hamstring and decreasing the disability due to low back Pain.
Comparison of Kinesiotaping and Rigid Taping on Trapezitis Induced due to Rounded Shoulder Posture in Desk Job Workers
Authors: Chamle Dr. Sujata , Akhter Rizvi Dr. Syed Rais
Published: July 2022

Background and purpose: Kinesio-taping and Rigid taping technique both have been showed improvement in trapezitis induced due to rounded shoulder posture. The objective of the study was to find out the comparative effectiveness of kinesio-taping and rigid taping in trapezitis induced due to rounded shoulder posture in desk job workers.
Method: This study was an Experimental study design. The samples were selected on the basis of Convenient sampling with random allocation of samples. 50 subjects were selected, in the age ranging from 20-50 years were assigned into two groups; Group A kinesio taping technique (25 subjects) and Group B rigid taping technique (25 subjects) for 2 weeks with 3 days per week, Pain was measured using Numerical pain rating scale (NPRS) and neck disability was assessed using Neck disability index (NDI). Both scales were taken pre intervention and post intervention at the end of two week.
Results: Result of the present study demonstrated that both the interventions in group-A and group-B were found to be individually effective in treating subjects having Trapezitis induced due to rounded shoulder posture in reducing pain and disability.
Conclusion: The present study concludes that both the interventions of Kinesio taping and rigid taping was individually effective in trapezitis induce due to rounded shoulder posture in desk job workers. It is also concluded that both the intervention techniques effective in decreasing the pain and disability. however, while compared the post test outcomes in between the groups, there was no much difference in reduction of pain and disability of the subjects.
Implication: kinesio taping and rigid taping is effective in improving pain, disability in trapezitis induced due to rounded shoulder posture.

Keywords: kinesio taping, rigid taping, neck disability index, numerical pain rating scale.
Friend or Foe: How to Suppress and Measure Fat During Abdominal Resonance Imaging?
Authors: Kim Hokun , Choi Joon-Il , Lee Hyun-Soo
Published: July 2022

The suppression of fat signals in abdominal magnetic resonance imaging has become a basic and routine practice in the diagnosis of pathologic conditions of abdominal organs in clinical settings. Many fat-suppression techniques have been developed in the past several decades, with fat-quantification methods introduced in response in more recent years. Fat-suppression techniques can be divided into two categories. Chemical shift–based techniques include chemical shift selective (CHESS), water excitation, and the Dixon method. CHESS is the most commonly used fat-suppression method, nulling the fat signal using a fat-selective radiofrequency pulse with a spoiler gradient. Water excitation employs a binomial pulse that excites only the water protons. Finally, the Dixon method involves using the in-phase/out-of-phase cycling of fat and water. An inversionbased technique, known as short tau inversion recovery (STIR), uses a pre-excitation inversion pulse that inverts the spin of all tissues. By selecting the appropriate MRI inversion time such that the longitudinal magnetization of fat is zero, fat protons will not contribute to the MRI signal. Also, spectral attenuated inversion recovery (SPAIR) is a hybrid technique that combines the characteristics of both CHESS and STIR. The most precise fat-quantification technique known to date is a complex-based multipoint Dixon method, with which the protondensity fat fraction (PDFF) can be obtained. Multiple confounding factors must be well-corrected for accurate fat quantification. Radiologists should be familiar with the various fat suppression and measurement methods during MRI and be able to apply them to enhance patient care.
Early Adiposity Rebond in Moroccan Children: Prevalence and Determinants
Authors: Tahiri K , Abidli Z , Turk J El , Amri A , Elarabiq F , Hannoun Z , Bour A
Published: July 2022

Background: Childhood obesity is a real public health problem Q, Its incidence is rapidly increasing in developing countries. According to the literature review, early rebound fat is associated with obesity and non-communicable diseases, our objective is therefore to determine the risk factors for early rebound fat in a population of Moroccan children. Material and methods: This retrospective epidemiological study lasted 12 months in 2018. The study involved 200 mother-child couples seen for consultation in an urban health centre at Salé city. Data were collected from a survey on the living conditions of the first 1000 days of life of the children studied and completed by anthropometric measurements, as well as information from mothers and children health books. Results: The average age of the children is 42.3±18.9 months with a sex ratio towards females (46% male versus 54% female). In terms of the internal reliability of the survey, the value of the calculated Cronbach index is acceptable (α = 0.7). We have established that mothers who have practiced artificial breastfeeding or gave birth by cesarean and nursing mothers who took oral contraceptives are of a higher-risk of having a child with an early adiposity rebond compared to other categories, with an odds-ration respectively [Odds-Ratio = 4; IC 95% [2,15-7,45]; P-value = 0,000]; [Odds-Ratio =4. 7; 95% CI [2.46-9.08]; P-value=0.000] and ERA [Odds-Ratio =2.3; 95% CI [1.46-4.34]; P-value=0.000]. Conclusion: Early rebound of adiposity is apredictor of obesity with a whole range of possible cardiovascular and metabolic complications.
Physicians’ Antimalarial Utilization Practices in Children below 5 years in a Secondary and Primary Health Facilities in Delta State
Authors: JE Arute , E Agbamu , G Agare , CJ Achi , VU Odili , A Omomulere
Published: July 2022

Malaria is an epidemic with 1.3% reduction in annual per capital economic growth rate. This study was to assess physicians’ antimalarial utilization in children below five years and conformity to guidelines. This is a retrospective and cross-sectional random sampling of prescriptions of antimalarials in under five between January 2012 and December 2014 in the secondary facility and January 2012 to December 2017 in two health facilities. Data was recorded using WHO indicator forms and analyzed using SPSS. Exactly, 800 prescriptions giving a total of 1,243 and 1313 drugs were prescribed in the Secondary Facility (CH), Warri and Primary Health Care (PHC), Oria respectively with an average of drugs prescribed per encounter (DPPE), CH (3.1 ± 0.01) and PHC, (3.3 ± 0.1). Antimalarials, were the most prescribed. Generic prescription was more in PHC (59%) than in CH (58%). Syrups were most prescribed 70.96% in CH, Warri and 53% in PHC, Oria. However, 27(50.9%) of physicians based prescription on experience, 13(24.5%) and 4(7.5%) followed WHO and National Antimalarial Treatment Policy (NATP) guidelines respectively while (17.1%) on the efficacy of the antimalarial. The antimalarial utilization practices conform to the WHO guidelines although there are lapses. Prescription was predominantly based on experience.
Viability of Mesenchymal Stem Cells from Stromal Vascular Fraction to Tissue Engineering Scaffold Collagen, Calcium Alginate, Oxidized Cellulose, Gelatin, And Amnion Membrane (Primary Cell Culture in Vitro Study)
Authors: Sananta Panji , Andarini Sri , Suryanto Dradjat Respati , Kalsum Umi , Sri Wahyuni Endang , Elfiah Elfiah , Hexa Pandiangan Ray Asaf , Dhakka Siahaan Lasa
Published: July 2022

Introduction: Soft tissue engineering strategies targeting volume loss restoration has been developed as the current management of soft tissue defects. Important components of this method are cell sources, scaffold, and bioreactor. Adipose-derived mesenchymal stem cell (ADMSC) from a stromal vascular fraction (SVF) attached to scaffold and differentiated into defect tissue through cell communication. This study was aimed to investigate the viability of ADMSC from SVF combined with collagen, calcium alginate, oxidized cellulose, gelatin, and amnion membrane in vitro. Method: This true experimental done in the laboratory using 24 samples of SVF ADMSC that had been cryopreserved for 5 months and already get through the thawing process. Result: Based on the descriptive analysis with 4 repetition each group and control, gelatin shows average 90.928 and deviation standard 1,053, oxidized cellulose average 19,528 and deviation standard 2,543, collagen average 93,273 and deviation standard 1,195, calcium alginate average 92,953 and deviation standard 1,257, amnion membrane average 92,068 and deviation standard 2,467, control 95,995 and deviation standard 0,428. Conclusion: The use of gelatin, collagen, calcium alginate, and amnion membrane as scaffold show high viability results of ADMSC from SVF. Otherwise, oxidized cellulose scaffold has the lowest amount of viable cell. However, the most recommended scaffold material is amnion membrane because of the easiness of the production process, high availability, high potency of cell growth, and low cost.
Pharmacological activities of Curcumin: An update
Authors: Mahmood Alabdali Aya Yaseen , Chinnappan Sasikala , Abd Razik Basma M. , R Mogana , Ibrahim Khalivulla Shaik , H Rahman
Published: July 2022

In the past few years, multiple drugs have been produced from traditional raw materials and recent pandemic disease COVID-19 once again research on this matter is being conducted to determine potential therapeutic purposes of different Ayurvedic Indian medicines and herbs. One such medicinal herb is Curcuma longa. Curcumin is strong antioxidant, anti-inflammatory, antispasmodic, antiangiogenic, anti-carcinogenic, as shown by multiple in vitro and in vivo studies. The action of the growth factor receptors is inhibited by curcumin. The anti-inflammatory effect of curcumin is obtained on the cytokines, proteolytic enzymes, eicosanoids, and lipid mediators. The superoxide radicals, nitric oxide and hydrogen peroxide, are sifted by curcumin, while lipid peroxidation is inhibited. Such properties of the compound thus form the foundation for its various therapeutic and pharmacological effects could also hold antiviral properties including COVID-19. The aim of this research is to summarize the updated pharmacological activities of curcumin.
Cone Beam Computed Tomography and its Implications in Endodontics: A Literature Review
Authors: M Roma , Manaktala Nidhi , Nayak Vijayendranath , Hegde Shreya
Published: July 2022

The utilization of cone beam computed tomography from endodontic perspective has been a great tool in the diagnosis of pulp and periradicular infections. The application of this tool is expanding rapidly and is been highlighted in various aspects of literature over a decade now. The objective of this paper is to scrutinize the various applications of Cone-beam computed tomography (CBCT) in endodontics, and to highlight the need of this tool in the field of diagnosis and treatment planning of endodontic infections.
A Review on Formulation and Evaluation of Nanoniosomal Topical gel of Paclitaxel for skin cancer
Authors: Abdin Nasrina , Pratap Sahu Bhanu , Sofiur Rahman Sheikh
Published: July 2022

Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the goal for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Paclitaxel (PCT) is a chemotherapeutic agent used as a first-line treatment for a wide range of cancers, such as lung, ovarian, breast, prostate, head, and neck cancers, and AIDS-related Kaposi sarcoma. Currently, the marketed forms of Paclitaxel are intravenous formulations. Oral administration of Paclitaxel is unfortunately hampered due to its low bioavailability. This is explained by its low aqueous solubility, low permeability, high affinity for cytochrome P450 and P-glycoprotein. As another approach, drug carrier systems are extensively studied to enhance oral Paclitaxel bioavailability and reduce side effects. The niosomes provides several important advantages over conventional drug therapy. Structurally, niosomes are similar to liposomes, in that they are also made up of a bilayer. However, the bilayer in the case of niosomes is made up of non-ionic surface-active agents rather than phospholipids as seen in case of liposomes. Niosome nanoparticles are among these drug delivery systems, which have numerous applications in drug delivery and targeting. Niosomes are frequently used for loading drugs serving different purposes (e.g., anticancer, antiviral, and antibacterial agents). The aim of this review is to evaluate the extent of nanotherapeutics used in anti-cancer activity.
鐵路事業民營化Ⅱ
Authors: 林淑馨 林淑馨
Published: July 2022

公營事業具有公共性和企業性的雙重特質，隨著時代與環境的變遷，公營事業的存廢成為解決政府缺乏效率的一種手段，然而，民營化企業的公共性確保與否和企業性的達成與否，常為政治與經濟角力所左右，因為即使民營化，事業本身依然保有公共性的特質，一般民眾能否不受地理和經濟條件的限制而享受到安全的普遍性服務，乃成為檢視民營化政策成果的主要觀點。本合輯集結作者對各國國營事業民營化的長期觀察，特別是日本，期能提供國內在面臨公營事業轉型之際的另類思考，加速達成民營化的積極目的。
Design and Simulation of a Power System Composed of Grid-tied Five-level Inverter with LCL Filter
Authors:   Systems and Applications Engineering Laboratory (LISA), National School of Applied Sciences, Cady Ayyad University, Elamri Oumaymah , Oukassi Abdellah ,   Systems and Applications Engineering Laboratory (LISA), National School of Applied Sciences, Cady Ayyad University, Toubal Maamar Alla Eddine ,   Department of Electrical Engineering, Laboratoire Génie Electrique et Energies Renouvelables (LGEER), Hassiba Benbouali University of Chlef, El Bahir Lhoussain ,   Systems and Applications Engineering Laboratory (LISA), National School of Applied Sciences, Cady Ayyad University
Published: July 2022

This paper presents the analysis, design, and simulation of a power system composed of a grid-tied single-phase five-level inverter with an LCL filter. First, the analysis of the proposed system has been carried out in the decoupled Direct-Quadrature frame, where the Phase-Lock-Loop technique has been used for synchronizing the LCL-filter-connected-grid with the five-level inverter. Next, the design of the LCL filter has been discussed. In this paper, we focused on the active power control based on grid current adjustment using a proportional-integral regulator and a high-frequency modulation technique for the switching of a five-level inverter, where the Sinusoidal-Pulse-Width-Modulation technique is selected. All circuit design and control schemes are discussed step by step to provide the effectiveness of the system analysis. The theoretical analysis is verified through simulation results in MATLAB/Simulink environments. An important finding when using the five-level inverter in a grid-connect system is improving the system output voltage; the total standing voltage and the total harmonic distortion are decreased compared to a conventional H-bridge inverter. The results indicate that the total harmonic distortion of grid-current is less than 0.2%, which is according to the international standards.
Liver recovery in a child with hemophagocytic lymphohistiocytosis-induced acute liver failure
Authors: Kreisel Charles , Monde Alexandra , Carlisle Gregory , Toretsky Jeffrey , Terao Michael , Monde Alexandra
Published: July 2022

Introduction: Hemophagocytic lymphohistiocytosis is a rare condition with dysregulated multi-organ inflammation that may cause acute liver failure. It often presents with non-specific clinical features and can be difficult to diagnose.

Case Report: We present the case of a 2-year-old girl with lethargy, encephalopathy, poor oral intake, vomiting, and jaundice. Her labs indicated acute liver failure with additional findings of bicytopenia and elevated ferritin. Given high concern for hemophagocytic lymphohistiocytosis, we promptly consulted the hematology/oncology, transplant hepatology, and pharmacy services. Bone marrow biopsy initially showed no evidence of hemophagocytosis. Given our high clinical index of suspicion for hemophagocytic lymphohistiocytosis and its high mortality and morbidity, we initiated treatment with high dose dexamethasone, etoposide, and the recently approved biologic drug emapalumab, a monoclonal antibody against interferon gamma, despite not meeting full HLH-2004 diagnostic criteria. One day after treatment initiation, the final review of the bone marrow biopsy showed evidence of hemophagocytosis. Ultimately, with implementation of multidisciplinary rounds, close neurologic examinations, aggressive management of evolving hyperammonemia and cerebral edema, and early initiation of treatment, our patient achieved full liver recovery.

Conclusion: This patient’s presentation emphasizes the importance of having a broad differential when a patient presents with liver failure and cytopenias. Our management of this patient showcases the importance of expedient, multidisciplinary management for a complex critically ill pediatric patient. The patient’s survival and complete liver recovery with the treatment protocol given suggests emapalumab should be studied in future clinical trials as an important adjunctive treatment for patients with hemophagocytic lymphohistiocytosis with acute liver failure.
Double under muscle transposition in long-standing sixth nerve palsy: A case report
Authors: Sapthanakorn Withawat , Thiamthat Warakorn , Thitiwichienlert Suntaree
Published: July 2022

Introduction: To report a case of acquired esotropia after long-standing sixth nerve palsy with double under muscle transposition technique correction.

Case Report: A 41-year-old male presented with diplopia from an unruptured and thrombosed mid-basilar aneurysm that caused isolated left sixth nerve palsy for 18 months after undergoing surgery. He had left face turn, 66 prism diopters (PD) esotropia of the left eye, and a complete left abduction deficit. To improve a complete sixth nerve palsy, we performed a double-under muscle transposition (DUT) technique, vertical recti [superior and inferior (SR) and (IR)] were transposed under left lateral recuts (LR) muscle along with medical recuts (MR) recession. Following postoperative result at three months, he was found to be orthotropia at near and 8 PD of exotropia at distance. He also improved diplopia in the primary position and he could slightly abduct the left eye. He did not have any postoperative complication.

Conclusion: We demonstrated that a DUT technique can be a procedure of choice in patients with large angle deviation from paralytic strabismus.
Assessing the immediate outcomes and etiology of comatose adult subjects
Authors: Kumar M. R. Kiran , Noorulla K. A. S., M.D. , Talat M.D. Mehnaz , Kumar M.S. P. Rajesh
Published: July 2022

Introduction: Adult subjects who are a comatose present challenge to the treating healthcare professionals in Indian subjects. Prompt and proper handling of these subjects is vital to attain favorable outcomes. Attaining the diagnosis based on the etiology is vital to handle these subjects properly. Aims: The present study was conducted to assess the immediate outcomes and etiology of comatose adult subjects in Indian settings. Methods: The present prospective and observational clinical study included 150 adult comatose subjects admitted for etiologies other than non-traumatic cases and GCS of less than/equal to 10 in the Indian healthcare center.  In malignancy cases, 1.49% (n=1) subject died, whereas, 3.61% (n=3) subjects survived, in snake bite 5.97% (n=4) subjects died and 4.81% (n=4) subjects survived, in infection, 7.46% (n=5) subjects died and 19.27% (n=16) subjects survived, in metabolic cause, 13.43% (n=9) subjects died and 40.96% (n=34) subjects survived, and in stroke as etiology, 71.64% (n=48) subjects died and 31.32% (n=26) subjects survived. Based on GCS scores, 30% (n=45) subjects had GCS score of 3-6 where 56.71% (n=38) subjects died and 8.43% (n=7) subjects survived, whereas, there were 70% (n=105) subjects with GCS score of 7-10 where 43.28% (n=29) subjects died and 91.56% (n=76) subjects survived.
Raspberry ketone: an emerging molecule for treating depression and associated symptoms - molecular docking and pharmacokinetics studies
Authors: Kumar Sanjeev , Kumar Sunil , Garg Arun , Sethy Silky , Gulati Puja
Published: July 2022

After analyzing multiple pharmaceutical databases like ScienceDirect, PubMed, Google Scholar, and others, it was discovered that RK has yet to be linked to any anti-depressant action. The primary goal of this work was to use in-silico techniques to investigate the anti-depressant capability of RK against three major targets (monoamine oxidases, MAOs; human serotonin transporter, SERT; and serotonin receptors, 5HTs). Moreover, prediction of drug-likeliness, bioavailability, and pharmacokinetics of RK has been done using online computational tools (SwissADME, SwissTargetPrediction, and SwissBioisostere). Thein silico study indicated the emerging role of RK in the management of clinical depression. The pharmacokinetic studies, target prediction studies against 3 species, and biosisosteric-based studies also supported the possibilities of lead development. The study will open new avenues of application of this low-molecular-weight-ligand (LMWL) for the clinicians, chemists, and other scientific professionals in context to emerging depression challenges.
phytopharmacological review on Euphorbia thymifolia Linn
Authors: Bhutkar K. G. , Balasubramaniam A. , Chaudhari S. R.
Published: July 2022

The main aim of this paper is different pharmacological activity of plant Euphorbia thymifolia L. belongs to family Euphorbiaceae. The herb used as traditional folk medicine and commonly known as laghududhikaor choti‑dudhi.  The plant is annual, small branch, pubescent and contains white milky latex. The plant used in various therapeutic activity by using different solvent like ethanol, methanol, water etc. shows antimicrobial, antifungal, antiasthamatic, anticancer, antidiarrheal, laxative, antioxidant, antiviral, antidiabetic etc. the other pharmacological activity mention in given review article.
Prospective study on association of 25-hydroxy vitamin D3 and uterne fibroid
Authors: Pradhan Shobhana , Dash Subhalaxmi , Nanda Sudhanshu Sekhara , Pradhan Subrat , Kar Tushar
Published: July 2022

Objective:  To find the association of 25-hydroxy VitaminD3 and uterine fibroid. Study Design:This is a prospective case control study. Setting: The study was conducted at the PG Department of Obstetrics and Gynaecology , S.C.B. Medical College, Cuttack,Odisha, India.Material & Method: One  hundred diagnosed cases of uterine fibroid were included as cases. The control group comprised of age matched hundred healthy volunteers. After obtaining the written consent of cases and controls, they were subjected for routine haematological tests and for Serum total 25-hydroxy vitamin D  by chemiluminescent immunoassay (CLIA) method.   Ultrasound evaluations were performed by TVS and TAS as per on all consenting subjects. All the data collected were entered into the excel spread sheet and the statistical analysis was carried out by using the graph pad prism 8.0. The quantitative data were expressed as mean ± SD. P value < 0.05 was considered to be statistically significant and P value < 0.01 was considered to be highly significant. Conclusion: The mean vitamin D level in cases was 8.6±2.6 ng/ml while in controls it was 19.23±4.3 ng/ml. The levels of vitamin D were significantly less in fibroid patients than in healthy controls (p<0.001).
relationship of supplementary feeding, breast milk (MP-ASI) to infants with the event of diarrhea
Authors: Anggraeni Reni , Wati Nenden Lesmana , Nambiar Nisha , Sansuwito Tukimin Bin , Rahayu Sri Mulyati , Ramdaniati Sri
Published: July 2022

Background: Diarrhea is one of the causes of death in toddlers, one of the factors that causes diarrhea is MP ASI. Based on the largest proportion of diarrhea sufferers at the Baros Health Center in the last 3 months of October, November, and December, there were 87 infants aged 0-12 months, 29 infants aged 12-24 months, and 31 infants aged 25-60 months. Objective: To determine the relationship between complementary feeding and the incidence of diarrhea in infants aged 3-12 months in the working area of ​​the Baros Public Health Center, Sukabumi City. Methods: The study used a cross-sectional population and the total sampling was 48 infants aged 3-12 months. Data processing using Chi-Square. Results:  The inappropriate provision of complementary feeding to infants aged 3-12 months was 26 respondents (54.2%) and the appropriate ones were 22 respondents (45.8 %), the incidence of diarrhea in infants aged 3-12 months who had diarrhea as many as 28 respondents (58.6%) and who did not have diarrhea as many as 20 respondents (41.7%). Research shows that there is a relationship between giving complementary feeding to infants aged 3-12 months with the incidence of diarrhea with a value of 0.00 (<0.05).
Formulation and evaluation of anti-fungal and anti-bacterial novel herbal cream using Senna alata, Wrightia tinctoria and Datura metel
Authors: Chakkaravarthi M. Abishek , Balasubramanian P L.
Published: July 2022

The main intention of these studies was to formulate and evaluate a novel herbal cream which includes Senna alata,Wrightia tinctoria and Datura metel for the treatment of secondary skin infections. The most suitable route for skin infection is topical. The development of topical drug transport systems designed to have systemic results appears to be useful for a number of drugs as a result of the numerous advantages over traditional routes of drug administration. In this study a novel herbal cream formulation consisting of  Senna alata,Wrightia tinctoria and Datura metel was prepared. This study was subjected to in-vitro diffusion method. Microbiological studies were carried out the safety of materials used inside the formulation. The formulated cream was found to be safe and effective for the treatment of skin infection.