bluuebunny/crossref_metadata_2025 huggingface dataset:
A Methodology Study on the Optimal Detection of Oil and Moisture Content in Soybeans Using LF-NMR and Its 2D T1-T2 Nuclear Magnetic Technology
Authors: Zhang Yu , Zhao Jianxiang , Gu Ying , Zhang Yu , Chen Yi , Song Ping , Yang Tao
Published: April 2023

In this study, we aimed to provide an accurate method for the detection of oil and moisture content in soybeans. Introducing two-dimensional low-field nuclear magnetic resonance (LF-2D-NMR) qualitatively solved the problem of overlapping component signals that one-dimensional (1D) LF-NMR techniques cannot distinguish in soybean detection research. Soxhlet extraction, oven drying, LF-NMR spectrum, and LF-NMR oil and moisture content software were used to detect soybean oil and moisture content. The comparison showed that the LF-NMR oil and moisture content software was faster and more accurate than the other methods. The specific identification of the oil and moisture signals of soybean seeds using longitudinal relaxation time (T1) and transverse relaxation time (T2) successfully solved the problems of less mobile water, overlapping free water, and oil signals. Therefore, LF-2D-NMR can complement conventional LF-NMR assays, and this study provides a new method for the analysis and detection of moisture and oil in soybeans.
Tea Plantation Intercropping Legume Improves Soil Ecosystem Multifunctionality and Tea Quality by Regulating Rare Bacterial Taxa
Authors: Wang Ting , Duan Yu , Lei Xiaogang , Cao Yu , Liu Lefeng , Shang Xiaowen , Wang Menghe , Lv Chengjia , Ma Yuanchun , Fang Wanping , Zhu Xujun
Published: April 2023

Microorganisms play essential roles in soil-ecosystem multifunctionality. However, the contribution of their community assembly processes, composition, diversity, and keystone species to ecosystem multifunctionality is unclear, especially in tea-plantation ecosystems. In order to assess the effects of various intercropping patterns (tea-plant monoculture and tea plants, respectively, intercropped with soybean, soybean—milk vetch, soybean—red clover, and soybean—smooth vetch) on soil rare and abundant taxa, a field experiment was carried out. We found that tea plantation intercropping with legumes improved the soil-ecosystem multifunctionality by altering the soil environment, and ultimately benefited nutrient absorption and quality improvement of tea leaves. Whether it was in bacteria or fungi, rare taxa had a higher proportion of deterministic processes in community assembly than abundant taxa. Additionally, intercropping practices changed the soil environment, and rare bacterial taxa were assembled and shifted from variable selection to homogeneous dispersal. Intercropping practices significantly changed the bacterial and fungal communities’ composition, and rare taxa had higher α-diversity than abundant taxa. Increasing legume species in intercropping practice enhanced community dissimilarity to the tea monoculture by affecting soil pH, ammonium nitrogen, and nitrate nitrogen. Rare bacterial and fungal β-diversity exhibited stronger positive relationships with ecosystem multifunctionality (both average and multi-threshold approaches) compared to the corresponding abundant taxa. Furthermore, ecosystem multifunctionality under different intercropping practices was closely related to the keystone rare operational taxonomic units, especially rare bacterial species of Chloroflexi. Our results emphasize the disparate feedbacks of rare and abundant taxa to diverse intercropping practices, as well as the important connection between rare bacterial taxa and ecosystem multifunctionality.
Biochar Amends Saline Soil and Enhances Maize Growth: Three-Year Field Experiment Findings
Authors: Yue Yan , Lin Qimei , Li Guitong , Zhao Xiaorong , Chen Hao
Published: April 2023

Soil salinization is a significant obstacle to agricultural development in arid and semiarid regions. While short-term experiments have demonstrated the effective improvement of saline soils through biochar amendment, the long-term efficacy in sustainably ameliorating such soils remains uncertain. Addressing this knowledge gap, this study investigated the long-term effects of biochar amendment in a field setting by applying different rates of biochar to a salt-affected soil and cultivating silage maize for three consecutive years. The comprehensive assessment includes not only maize growth but also changes in soil physical and chemical properties over the study period. The results reveal a notable elevation in maize above-ground dry matter, directly correlated to the enhanced uptake of nitrogen, phosphorous, and potassium. Additionally, biochar application improves saline soil physical properties, including reduced bulk density (1–23%), increased soil large pores (0.7–12%), and macroaggregates (24–141%), and chemical properties, including a decrease in exchangeable sodium percentage (35–48%), and an increase in soil total organic carbon (112–857%), total nitrogen (9–198%), available nitrogen (12–49%), phosphorus (141–538%) and potassium (57–895%). These improvements ultimately resulted in better maize growth. However, the amelioration effect of biochar on these soil properties gradually diminished over the three-year study. Consequently, this study suggests that biochar is a promising soil amendment that can enhance maize growth in saline soil for at least three years in a field experiment, providing valuable insights for sustainable agricultural practices in salt-affected regions.
Pigeon Pea Intercropped with Tropical Pasture as a Mitigation Strategy for Enteric Methane Emissions of Nellore Steers
Authors: Furtado Althieres José , Abdalla Filho Adibe Luiz , Bruno Jaqueline Fernandes , Neto Rolando Pasquini , Lobo Annelise Aila Gomes , da Silva Gabriele Voltareli , Junior Flavio Perna , Alves Teresa Cristina , Berndt Alexandre , de Faria Pedroso André , de Medeiros Sérgio Raposo , Oliveira Patrícia Perondi Anchão , Rodrigues Paulo Henrique Mazza
Published: April 2023

In this study, we evaluate the effects of intercropping pigeon pea (Cajanus cajan (L.) Millsp.) with tropical pastures for feeding Nellore cattle and compared animal performance and enteric CH4 emissions with other pasture-based systems during the dry and rainy seasons of 2021. Thirty-six Nellore steers (with a body weight of 221 ± 7 kg and an age of 15–16 months) were randomly distributed in three treatments with three replicates (in paddocks of 1.5 hectares each): (1) a degraded pasture of Urochloa spp. (DEG); (2) a recovered and fertilized pasture of Urochloa spp. (REC); and (3) pigeon pea intercropped with Urochloa spp. (MIX). Enteric CH4 emissions were estimated using the sulfur hexafluoride (SF6) tracer gas technique, and dry matter intake (DMI) was determined using internal (iNDF) and external (TiO2) markers. Forages were collected by hand plucking after observations of ingestive behavior, and feces was collected after voluntary defecation. The proportion of grass and legume intake was estimated by C stable isotopes, and the forage nutritional quality was determined, while animal performance was monitored monthly, and the stocking rate was adjusted by the “put and take” technique. The results indicated that intercropping pigeon pea with tropical grasses is an interesting strategy for sustainable livestock production based on pastures. The MIX treatment was able to meet the nutritional requirements of the animals, which presented higher performance. In addition, there was a reduction in CH4 emissions up to 70% when expressed per average daily weight gain in comparison to the DEG treatment.
Sexing of Embryos at the Time of Twin Reduction: A Clinical Approach
Authors: López-Gatius Fernando , Garcia-Ispierto Irina
Published: April 2023

This study provides new unique information on bovine twin pairs during the late embryonic period (28–34 days of pregnancy) in relation to (1) a predictive ultrasound measurement that was differential for sexing heterosexual twins; (2) intrauterine embryonic growth patterns in twin pairs; and (3) a higher vulnerability of female embryos compared to males following an induced embryo reduction in heterosexual twins. The study population comprised 92 dairy cows carrying bilateral twins. A length difference between co-twins equal to or greater than 25% in around 50% of pregnancies served to determine the sex of embryos with 100% accuracy in heterosexual twins, which was assessed four weeks later on the remaining fetus after twin reduction. The apparent rates of growth of twin pairs and of individual male and female embryos from day 28 to 34 of gestation were similar to established growth pattern standards for singletons. Mean embryo sizes in relation to gestational age were smaller by some 5 days’ growth equivalent in twins compared to singletons. After the reduction in the female embryo in heterosexual twins, the risk of male embryo loss was null. This new information allowed for sex selection at the time of twin reduction.
Fruit–Carrot-Based Smoothies as Innovative Products with a Complex Matrix of Bioactive Compounds Effected on Activities of Selected Digestive Enzymes and Cholinesterases In Vitro
Authors: Yusuf Emel Hasan , Wojdyło Aneta , Bourbon Ana Isabel , Nowicka Paulina
Published: April 2023

In this study, four different carrot varieties (purple, yellow, white, and orange) were used in the production of smoothies with raspberry, apple, pear, strawberry, and sour cherry juices. The in vitro inhibition effects against α- amylase, α- glucosidase, pancreatic lipase, acetylcholinesterase, and butyrylcholinesterase were measured, bioactive compounds, physicochemical characteristics, including sensorial features were described. The antioxidant activities of the studied samples were analyzed using the ORAC, ABTS, and FRAP methods. The raspberry–purple carrot smoothie showed the highest antioxidant activity against lipase and butyrylcholinesterase enzyme activity. The sour cherry–purple carrot smoothie showed the highest total soluble solids, total phenolic acid, total anthocyanins, and procyanidin contents; dry mass; and osmolality. Although the apple–white carrot smoothie achieved the highest acceptance after sensorial evaluation, it did not exhibit any potent biological activities. Thus, food products with purple carrot, raspberry, and sour cherry ingredients are suggested as functional and/or novel matrix compositions with high antioxidant potential.
Neural Network-Assisted Interferogram Analysis Using Cylindrical and Flat Reference Beams
Authors: Khorin Pavel A. , Dzyuba Alexey P. , Chernykh Aleksey V. , Georgieva Aleksandra O. , Petrov Nikolay V. , Khonina Svetlana N.
Published: April 2023

In this paper, we present the results of a comparative analysis of the sensitivity of interferograms to wavefront aberrations recorded with flat and cylindrical reference beams. Our results show that compared to classical linear interferograms based on flat wavefronts, cylindrical interferograms have at least 10% higher sensitivity for radially asymmetric types of aberrations and a 30% decrease in average absolute error for aberration recognition using a convolutional neural network. The use of cylindrical reference beams leads to an increase in the sensitivity of interferograms for detecting medium and strong aberrations.
Rolling Tires on the Flat Road: Thermo-Investigation with Changing Conditions through Numerical Simulation
Authors: Nguyen Thanh-Cong , Cong Khanh-Duy Do , Dinh Cong-Truong
Published: April 2023

A crucial material comprising a pneumatic tire is rubber. In general, the tire, or more specifically, the hysteresis effects brought on by the deformation of the part made of rubber during the procedure, heat up the part. In addition, the tire temperature depends on several factors, including the inflation pressure, automobile loading, car speed, road tire, the environmental conditions, and the tire geometry. This work focuses on using simulations to calculate the temperature and generated heat flow distributions of a rolling tire with constant velocity using the finite element method. For the sake of simplicity, it is assumed that the only components of the tire are rubber, body-ply, bead wire, and the rim. While the other components are believed to be made of a linear elastic material, the nonlinear mechanical behavior of the rubber is characterized by a Mooney–Rivlin model. Investigations are conducted into the combined effects of vehicle loads and inflation pressure. Hysteresis energy loss is used as a bridge to link the strain energy density to the heat source in rolling tires, and their temperature and heat flow distributions may be determined by steady-state thermal analysis. Thanks to the state-of-the-art computing method, the time required for connected 3D dynamic rolling tire simulations is reduced. The simulation outcomes demonstrate that the maximum temperature in this paper is attained with high weights, high velocities, and low inner inflated pressures. Overall, the maximum temperature is increased with the rise of all three variables. Moreover, the rise of the friction coefficient between the tread and road surface moves the high-temperature area towards the tread/sidewall connection area.
Role of Technology Innovation in Telemedicine: Focus on Sport Nutrition
Authors: Vasco Paride , Moscatelli Fiorenzo , La Torre Maria Ester , Valenzano Anna , Monda Vincenzo , Cibelli Giuseppe , de Stefano Maria Ida , Marsala Gabriella , Dalia Carmine , Bassi Paola , Porro Chiara , Toto Giusi , Limone Pierpaolo , Messina Giovanni , Polito Rita
Published: April 2023

Due to the COVID-19 pandemic, there has been a significant transformation in the field of telehealth and telemedicine, as systems have been improved to meet the increased demand for remote healthcare services. Many ordinary technologies have been equipped to facilitate the normal relationship between patients and specialists. These technologies were put into action in a short period of time, creating a gap between the limits of common technologies and the special needs of telemedicine patients. Furthermore, focusing the lens on the special needs of sports in terms of nutrition, we see that research demonstrates the possibility of improving athletic performance by introducing technological diet support. This review aims to provide an overview of the technologies successfully implemented in telemedicine systems, a look at new modeling approaches, and a study on the roles of new enabling technologies in the process. It aims to highlight the results of the employment of telemedicine in sports dietary support and present open research challenges and recommendations for future research on a new application of technologies in telemedicine, for both the industrial and academic sectors. Literature was identified through intensive research work, reviewing articles related to the topics of new technologies in telemedicine and sports dietary support systems. The review concludes that it is possible to envisage the design of future models in the eHealth sector related to nutrition and sports, confirming the important role of telemedicine in a healthy lifestyle.
A Proposal for Basic Formal Ontology for Knowledge Management in Building Information Modeling Domain
Authors: Park Hyunsoung , Shin Sangyun
Published: April 2023

The construction industry produces enormous amounts of information, relying on building information modeling (BIM). However, due to interoperability issues, valuable information is not being used properly. Ontology offers a solution to this interoperability. A complete knowledge base can be provided by reusing basic formal ontology (BFO). In previous studies, domain ontology was developed without BFO. Domain ontology requires loads of effort to reuse because domain ontology is too detailed. To increase the reuse rate and establish a complete knowledge base, it is necessary to develop BFO. This study has developed the BFO in the BIM domain to advance interoperability. First, unnecessary parts were omitted from the existing BFO development process, the process was simplified, and the base of hierarchy was created by extracting the most basic superclasses of the BFO model from Revit, the software of BIM. Based on that hierarchy, each child class was created, and the BFO model was completed by completing the relation of each class. After completion of the model, reliability, in addition to the completeness of the model, was evaluated through a query. Domain experts can reuse the BFO when defining relations between concepts and entities. The proposed BFO will be the foundation of future ontology developments in the BIM domain. This study facilitates future researchers to enhance interoperability in the BIM domain and make the ontology more complete to improve information sharing.
A Novel MPPT Based Reptile Search Algorithm for Photovoltaic System under Various Conditions
Authors: Douifi Nadia , Abbadi Amel , Hamidia Fethia , Yahya Khalid , Mohamed Mahmoud , Rai Nawal
Published: April 2023

Solar systems connected to the grid are crucial in addressing the global energy crisis and meeting rising energy demand. The efficiency of these systems is totally impacted by varying weather conditions such as changes in irradiance and temperature throughout the day. Additionally, partial shading (PS) adds to the complexity of the nonlinear characteristics of photovoltaic (PV) systems, leading to significant power loss. To address this issue, maximum power point tracking (MPPT) algorithms have become an essential component in PV systems to ensure optimal power extraction. This paper introduces a new MPPT control technique based on a novel reptile search optimization algorithm (RSA). The effectiveness of the proposed RSA method is evaluated under different weather conditions with varying irradiance and partial shading. The results of the RSA algorithm are compared to other existing bio-inspired algorithms and show superior performance with an average efficiency of 99.91%, faster dynamic response of 50 ms, and less than 20 watts of oscillation. The RSA-MPPT based technique provides higher efficiency, faster settling time, and minimal oscillation around the maximum power point (MPP), making it a reliable solution for effective solar power harvesting.
Advanced Technologies on Mine Dust Prevention and Control
Authors: Liu Guoming , Hou Minghui
Published: April 2023

Coal is the most abundant and widely distributed fossil energy source on the planet [...]
Design of an Adaptive Algorithm for Feeding Volume–Traveling Speed Coupling Systems of Rice Harvesters in Southern China
Authors: Deng Lexing , Liu Tianyu , Jiang Ping , Xie Fangping , Zhou Junchi , Yang Wenhan , Qi Aolin
Published: April 2023

We developed an adaptive algorithm to reduce rice loss in harvesting, promote threshing and improve the quality and efficiency of small- and medium-sized rice harvesters operating in southern China’s hilly and mountainous areas. Using a fuzzy PID control algorithm, the harvester adapts to the rice harvesting conditions in southern China, and monitors rice feed volume changes and instantly adjust the traveling speed to optimize feed volume levels and threshing quality. We compared and analyzed the algorithm and the traditional PID control regulation effect in the simulation experiment. The algorithm had a quicker response speed and stable accuracy. In the field trial, the average error rate was 3.4%, and the maximum error rate was 5.1%, with most data points centered around the ideal feeding rate of 3.2 kg/s. Our results showed that the algorithm’s stability, accuracy, and real-time performance met the threshing loss reduction requirements of southern China’s rice harvesting operations.
On the Radon-Related Mechanism of the Seismo- and Volcanogenic Geomagnetic Anomalies: Experiments in Tlamacas Mountain (Volcano Popocatepetl Area) and Electrode Effect Model
Authors: Yutsis Vsevolod , Kotsarenko Anatolyi , Grimalsky Vladimir , Pulinets Sergey
Published: April 2023

The noise-like behavior of the geomagnetic anomalies observed in Tlamacas station (volcano Popocatepetl, Mexico), linked to the ionization produced by intensive radon release, are presented in the experimental part of this study. The magnetic field perturbations produced by charge spreading currents within the fair-weather electric field are considered in the theoretical model based on the electrode. The electric charges are generated by the air ionization due to radon emanation. The simulations demonstrated that the ionization of the air leads to magnetic field perturbations of about 0.001–0.1 nT in the ULF (ultra low frequency) range 10−3–10−1 Hz. Magnetic field perturbations can be higher when the radon emanation occurs in a region with terrain irregularities.
Hierarchies of the Korteweg–de Vries Equation Related to Complex Expansion and Perturbation
Authors: Redkina Tatyana V. , Zakinyan Arthur R. , Zakinyan Robert G. , Surneva Olesya B.
Published: April 2023

We consider the possibility of constructing a hierarchy of the complex extension of the Korteweg–de Vries equation (cKdV), which under the assumption that the function is real passes into the KdV hierarchy. A hierarchy is understood here as a family of nonlinear partial differential equations with a Lax pair with a common scattering operator. The cKdV hierarchy is obtained by examining the equation on the eigenvalues of the fourth-order Hermitian self-conjugate operator on the invariant transformations of the eigenvector-functions. It is proved that for an operator H^n to transform a solution of the equation on eigenvalues M^−λEV=0 into a solution of the same equation, it is necessary and sufficient that the complex function ux,t of the operator M^ satisfies special conditions that are the complexifications of the KdV hierarchy equations. The operators H^n are constructed as differential operators of order 2n + 1. We also construct a hierarchy of perturbed KdV equations (pKdV) with a special perturbation function, the dynamics of which is described by a linear equation. It is based on the system of operator equations obtained by Bogoyavlensky. Since the elements of the hierarchies are united by a common scattering operator, it remains unchanged in the derivation of the equations. The second differential operator of the Lax pair has increasing odd derivatives while retaining a skew-symmetric form. It is shown that when perturbation tends to zero, all hierarchy equations are converted to higher KdV equations. It is proved that the pKdV hierarchy equations are a necessary and sufficient condition for the solutions of the equation on eigenvalues to have invariant transformations.
Structure-Function of the Human WAC Protein in GABAergic Neurons: Towards an Understanding of Autosomal Dominant DeSanto–Shinawi Syndrome
Authors: Rudolph Hannah C. , Stafford April M. , Hwang Hye-Eun , Kim Cheol-Hee , Prokop Jeremy W. , Vogt Daniel
Published: April 2023

Dysfunction of the WW domain-containing adaptor with coiled-coil, WAC, gene underlies a rare autosomal dominant disorder, DeSanto–Shinawi syndrome (DESSH). DESSH is associated with facial dysmorphia, hypotonia, and cognitive alterations, including attention deficit hyperactivity disorder and autism. How the WAC protein localizes and functions in neural cells is critical to understanding its role during development. To understand the genotype–phenotype role of WAC, we developed a knowledgebase of WAC expression, evolution, human genomics, and structural/motif analysis combined with human protein domain deletions to assess how conserved domains guide cellular distribution. Then, we assessed localization in a cell type implicated in DESSH, cortical GABAergic neurons. WAC contains conserved charged amino acids, phosphorylation signals, and enriched nuclear motifs, suggesting a role in cellular signaling and gene transcription. Human DESSH variants are found within these regions. We also discovered and tested a nuclear localization domain that impacts the cellular distribution of the protein. These data provide new insights into the potential roles of this critical developmental gene, establishing a platform to assess further translational studies, including the screening of missense genetic variants in WAC. Moreover, these studies are essential for understanding the role of human WAC variants in more diverse neurological phenotypes, including autism spectrum disorder.
Defining Patterns and Rates of Natural vs. Drought Driven Aquatic Community Variability Indicates the Ongoing Need for Long Term Ecological Research
Authors: Pozojević Ivana , Dorić Valentina , Miliša Marko , Ternjej Ivančica , Ivković Marija
Published: April 2023

Most ecologists have used climate change, as an omnipresent pressure, to support their findings in researching the vulnerability of specific taxa, communities, or ecosystems. However, there is a widespread lack of long-term biological, biocoenological, or community data of periods longer than several years to ascertain patterns as to how climate change affects communities. Since the 1950s, southern Europe has faced an ongoing trend of drying and loss of precipitation. A 13-year research program in the Dinaric karst ecoregion of Croatia aimed to comprehensively track emergence patterns of freshwater insects (true flies: Diptera) in a pristine aquatic environment. Three sites, spring, upper, and lower tufa barriers (calcium carbonate barriers on a barrage lake system that act as natural damns), were sampled monthly over 154 months. This coincided with a severe drought event in 2011/2012. This was the most significant drought (very low precipitation rates for an extended period of time) in the Croatian Dinaric ecoregion since the start of detailed records in the early 20th century. Significant shifts in dipteran taxa occurrence were determined using indicator species analysis. Patterns of seasonal and yearly dynamics were presented as Euclidian distance metrics of similarity in true fly community composition compared at increasing time intervals, to ascertain the degree of temporal variability of similarity within the community of a specific site and to define patterns of similarity change over time. Analyses detected significant shifts in community structure linked to changes in discharge regimes, especially to the drought period.
Stability of ACE2 Peptide Mimetics and Their Implications on the Application for SARS-CoV2 Detection
Authors: Santana Paula A. , Álvarez Claudio A. , Valenzuela Santiago , Manchego Alberto , Guzmán Fanny , Tirapegui Cristian , Ahumada Manuel
Published: April 2023

The SARS-CoV-2 worldwide outbreak prompted the development of several tools to detect and treat the disease. Among the new detection proposals, the use of peptides mimetics has surged as an alternative to avoid the use of antibodies, of which there has been a shortage during the COVID-19 pandemic. However, the use of peptides in detection systems still presents some questions to be answered, mainly referring to their stability under different environmental conditions. In this work, we synthesized an ACE2 peptide mimic and evaluated its stability in different pH, salinity, polarity, and temperature conditions. Further, the same conditions were assessed when using the ability of the peptide mimic to detect the recombinant SARS-CoV-2 spike protein in a biotin-streptavidin-enzyme-linked assay. Finally, we also tested the capacity of the peptide to detect SARS-CoV-2 from patients’ samples. The results indicate that the peptide is structurally sensitive to the medium conditions, with relevance to the pH, where basic pH favored its performance when used as a SARS-CoV-2 detector. Further, the proposed peptide mimic was able to detect SARS-CoV-2 comparably to RT-qPCR results. Therefore, the present study promotes knowledge advancement, particularly in terms of stability considerations, in the application of peptide mimics as a replacement for antibodies in detection systems.
A Comparison in Travel Characteristics of Bike-Sharing between College Students and Office Workers Based on Theory of Planned Behavior
Authors: Duan Yuzhou , Wang Jiale , Li Hui , Yan Yibo , Zhang Xu
Published: April 2023

As an important component of bike-sharing (BS) users, the travel behavior of college students and office workers is important to the promotion of BS within Chinese cities. To explore the influencing factors for the behavioral intentions of BS, this paper makes a different analysis between the two groups. Based on the theory of planned behavior, and using environmental awareness as an extended variable, a BS travel intention model was developed. A total of 676 valid questionnaires were collected and analyzed from college students and office workers in Zhengzhou. The results indicate that attitude, subjective norms, perceived behavior control, and environmental awareness have a positive impact on the behavioral intentions of BS. However, the influence degree of each variable is different between the two groups. Perceived behavior control, including travel time, travel cost, and cycling difficulty, has the greatest impact on BS behavioral intention for college students. Meanwhile, subjective norms, including policy and media publicity, has the most significant impact on BS behavioral intention for office workers. The impact of environmental awareness on college students’ use of BS is higher than that of office workers. We also found that undergraduates use BS more frequently than postgraduates. The findings provide the clear influence factors on behavioral intentions of BS between college students and office workers, that can help policy optimization in terms of bike-sharing systems, giving some suggestion for an approach devoted to deepen the individual-context interactions
Effect of Microwave Radiation on the Compressive Strength of Solid Ceramic Brick
Authors: Průša David , Šuhajda Karel , Žajdlík Tomáš , Svobodová Kateřina , Šťastník Stanislav , Hobzova Klara , Venkrbec Vaclav
Published: April 2023

Microwave radiation is widely utilized in construction practice, especially for drying building materials, remediating damp masonry, or sterilization of biotic pests that have infested building structures. The available scientific and technical literature reports that certain materials exposed to microwave radiation do not change their physical and mechanical properties, although this has not yet been adequately verified. This paper builds on many years of research in the area, adding to and refining existing information, providing new insights into the mechanical and physical properties of commonly available building materials that have been exposed to controlled microwave radiation, and comparing them with reference values. The experimental research on a set of clay brick samples is carried out using tests according to European standards, and it focuses on the effect of microwave radiation on compressive strength and water absorption. The experimental samples were compared to reference samples that had not been subjected to prolonged exposure to moisture and were subsequently treated with microwave radiation for dehumidification.
Assessing the Influence of Total Quality Management on Customer Satisfaction in the Telecom Industry: A TQM–SERVQUAL Perspective
Authors: Owusu-Kyei Michael , Kong Yusheng , Owusu Akomeah Michael , Owusu Afriyie Stephen
Published: April 2023

Total quality management (TQM) has become a reliable quality and customer satisfaction approach that can meet or exceed customer satisfaction. Previous studies have not really tied total quality management in the aspects of SERVQUAL as the major influence on customer satisfaction in the Ghanaian telecommunication sector, thus the need for this research. As customer satisfaction continues to rise, telecommunication customers expect service quality to improve to meet their satisfaction. The quality of service determines the customer satisfaction level in a service industry, such as telecom. Effective total quality management would result in better service quality. SERVQUAL is arguably the model to assess the effectiveness of customer satisfaction in the service industry. The aim of this study is to assess the influence of total quality management on customer satisfaction in the telecom industry from a TQM–SERVQUAL perspective. The study relied on questionnaires to gather data about the TQM services on customer satisfaction. A self-completion questionnaire was administered to customers and employees of MTN Ghana and Vodafone Ghana. Both companies operate with the same procedures and equipment, hence the need to use the same apparatus for all contacted customers and employees. There were 800 respondents from both companies’ employees and customers, although 850 questionnaires were administered. Descriptive statistical analysis was used through the questionnaire. The investigators also ran preliminary tests such as reliability, validity, and multicollinearity tests to ascertain if the received data were reasonable enough for the research and would fit the expected model. The data collected were analyzed and the inference was drawn in the study. The key finding states that total quality management had a significant impact on service quality and customer satisfaction. It is also concluded that service quality has a positive influence on customer satisfaction. Moreover, service quality has been detected as a major variable of TQM in achieving customer satisfaction in telecommunication companies in Ghana.
The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage
Authors: Noce Annalisa , Marrone Giulia , Di Lauro Manuela , Mitterhofer Anna Paola , Ceravolo Maria Josè , Di Daniele Nicola , Manenti Guglielmo , De Lorenzo Antonino
Published: April 2023

In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic dissemination) or by chemotherapy, as it is potentially nephrotoxic. Kidney damage can manifest as acute kidney injury or represent a worsening of pre-existing chronic kidney disease. In cancer patients, physicians should try to set preventive strategies to safeguard the renal function, avoiding the concomitant use of nephrotoxic drugs, personalizing the dose of chemotherapy according to the glomerular filtration rate (GFR) and using an appropriate hydration therapy in combination with nephroprotective compounds. To prevent renal dysfunction, a new possible tool useful in the field of onco-nephrology would be the development of a personalized algorithm for the patient based on body composition parameters, gender, nutritional status, GFR and genetic polymorphisms.
Clinical Outcomes of Thymic Carcinoma: The Role of Radiotherapy Combined with Multimodal Treatments
Authors: Yang Gowoon , Lee Chang Young , Kim Eun Young , Lee Chang Geol , Hong Min Hee , Park Byung Jo , Yoon Hong In , Kim Kyung Hwan , Lee Sang Hoon , Byun Hwa Kyung , Cho Jaeho
Published: April 2023

Introduction: We aimed to identify the role of radiotherapy (RT) in the treatment of thymic carcinoma as well as the optimal RT target volume. Materials and Methods: This single-institution retrospective study included 116 patients diagnosed with thymic carcinoma between November 2006 and December 2021 who received multimodal treatment including RT with or without surgery or chemotherapy. Seventy-nine patients (68.1%) were treated with postoperative RT, 17 patients (14.7%) with preoperative RT, 11 patients (9.5%) with definitive RT, and nine patients (7.8%) with palliative RT. The target volume was defined as the tumor bed or gross tumor with margin, and selective irradiation of the regional nodal area was performed when involved. Results: With a median follow-up of 37.0 (range, 6.7–174.3) months, the 5-year overall survival (OS), progression-free survival, and local recurrence-free survival rates were 75.2%, 47.7% and 94.7%, respectively. The 5-year OS was 51.9% in patients with unresectable disease. Overall, 53 recurrences were observed, of which distant metastasis was the most common pattern of failure (n = 32, 60.4%) after RT. No isolated infield or marginal failures were observed. Thirty patients (25.8%) who had lymph node metastases at the initial diagnosis had regional nodal areas irradiated. There was no lymph node failure inside the RT field. A tumor dimension of ≥5.7 cm (hazard ratio [HR] 3.01; 95% confidence interval [CI] 1.25–7.26; p = 0.030) and postoperative RT (HR 0.20; 95% CI 0.08–0.52; p = 0.001) were independently associated with OS. Intensity-modulated-RT-treated patients developed less overall toxicity (p < 0.001) and esophagitis (p < 0.021) than three-dimensional-conformal-RT-treated patients. Conclusions: A high local control rate was achieved with RT in the primary tumor sites and involved lymph node area in the treatment of thymic carcinoma. A target volume confined to the tumor bed or gross tumor plus margin with the involved lymph node stations seems reasonable. The advanced RT techniques with intensity-modulated RT have led to reduced RT-related toxicity.
Novel CDK12/13 Inhibitors AU-15506 and AU-16770 Are Potent Anti-Cancer Agents in EGFR Mutant Lung Adenocarcinoma with and without Osimertinib Resistance
Authors: Maity Tapan K. , Kim Eun Young , Cultraro Constance M. , Venugopalan Abhilash , Khare Leena , Poddutoori Ramulu , Marappan Sivapriya , Syed Samiulla D. , Telford William G. , Samajdar Susanta , Ramachandra Murali , Guha Udayan
Published: April 2023

Osimertinib is a third-generation epidermal growth factor receptor and tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of lung adenocarcinoma patients harboring EGFR mutations. However, acquired resistance to this targeted therapy is inevitable, leading to disease relapse within a few years. Therefore, understanding the molecular mechanisms of osimertinib resistance and identifying novel targets to overcome such resistance are unmet needs of cancer patients. Here, we investigated the efficacy of two novel CDK12/13 inhibitors, AU-15506 and AU-16770, in osimertinib-resistant EGFR mutant lung adenocarcinoma cells in culture and xenograft models in vivo. We demonstrate that these drugs, either alone or in combination with osimertinib, are potent inhibitors of osimertinib-resistant as well as -sensitive lung adenocarcinoma cells in culture. Interestingly, only the CDK12/13 inhibitor in combination with osimertinib, although not as monotherapy, suppresses the growth of resistant tumors in xenograft models in vivo. Taken together, the results of this study suggest that inhibition of CDK12/13 in combination with osimertinib has the potential to overcome osimertinib resistance in EGFR mutant lung adenocarcinoma patients.
Adult Patients with Cancer Have Impaired Humoral Responses to Complete and Booster COVID-19 Vaccination, Especially Those with Hematologic Cancer on Active Treatment: A Systematic Review and Meta-Analysis
Authors: Liatsou Efstathia , Ntanasis-Stathopoulos Ioannis , Lykos Stavros , Ntanasis-Stathopoulos Anastasios , Gavriatopoulou Maria , Psaltopoulou Theodora , Sergentanis Theodoros N. , Terpos Evangelos
Published: April 2023

The exclusion of patients with cancer in clinical trials evaluating COVID-19 vaccine efficacy and safety, in combination with the high rate of severe infections, highlights the need for optimizing vaccination strategies. The aim of this study was to perform a systematic review and meta-analysis of the published available data from prospective and retrospective cohort studies that included patients with either solid or hematological malignancies according to the PRISMA Guidelines. A literature search was performed in the following databases: Medline (Pubmed), Scopus, Clinicaltrials.gov, EMBASE, CENTRAL and Google Scholar. Overall, 70 studies were included for the first and second vaccine dose and 60 studies for the third dose. The Effect Size (ES) of the seroconversion rate after the first dose was 0.41 (95%CI: 0.33–0.50) for hematological malignancies and 0.56 (95%CI: 0.47–0.64) for solid tumors. The seroconversion rates after the second dose were 0.62 (95%CI: 0.57–0.67) for hematological malignancies and 0.88 (95%CI: 0.82–0.93) for solid tumors. After the third dose, the ES for seroconversion was estimated at 0.63 (95%CI: 0.54–0.72) for hematological cancer and 0.88 (95%CI: 0.75–0.97) for solid tumors. A subgroup analysis was performed to evaluate potential factors affecting immune response. Production of anti-SARS-CoV-2 antibodies was found to be more affected in patients with hematological malignancies, which was attributed to the type of malignancy and treatment with monoclonal antibodies according to the subgroup analyses. Overall, this study highlights that patients with cancer present suboptimal humoral responses after COVID-19 vaccination. Several factors including timing of vaccination in relevance with active therapy, type of therapy, and type of cancer should be considered throughout the immunization process.
Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine
Authors: Zhang Qixian , Gerweck Leo E. , Cascio Ethan , Gu Liqun , Yang Qingyuan , Dong Xinyue , Huang Peigen , Bertolet Alejandro , Nesteruk Konrad Pawel , Sung Wonmo , McNamara Aimee L. , Schuemann Jan
Published: April 2023

Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm2 elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1−/−/C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes.
Improvement of Lung NET Management through Standardized Care—A Swiss Nationwide Observational Study
Authors: Schmidlin Moira , Sadowski Samira M. , Siebenhüner Alexander , Wild Damian , Christ Emanuel , Refardt Julie
Published: April 2023

Typical (TC) and atypical carcinoids (AC) are the most common neuroendocrine tumors (NETs) of the lung. Because these tumors are rare, their management varies widely among Swiss centers. Our aim was to compare the management of Swiss patients before and after the publication of the expert consensus of the European Neuroendocrine Tumor Society (ENETS) in 2015. We used data from the Swiss NET registry from 2009 to 2021 with patients with TC and AC. Survival analysis was performed using the Kaplan–Meier method and log-rank test. Overall, 238 patients were included, 76% (180) thereof with TC and 24% (58) with AC, including 155 patients before and 83 patients after 2016. An increase in the use of functional imaging was observed, 16% (25) before and 35% (29) after 2016, p < 0.001. The presence of SST2A-receptors was determined more often: 32% (49 times) before 2016 and 47% (39 times) after, p = 0.019. Concerning therapy, higher removal of lymph nodes after 2016 was observed, 54% (83) before versus 78% (65) after, p < 0.001. Median overall survival for patients with AC was significantly shorter, with 89 months compared to 157 months for patients with TC, p < 0.001. While the implementation of a more standardized approach was observed over the years, there is still room for amelioration in the management of TC and AC in Switzerland.
Prospective Observational Study of Prevalence, Assessment and Treatment of Pancreatic Exocrine Insufficiency in Patients with Inoperable Pancreatic Malignancy (PANcreatic Cancer Dietary Assessment—PanDA)
Authors: Carnie Lindsay E. , Shah Dinakshi , Vaughan Kate , Kapacee Zainul Abedin , McCallum Lynne , Abraham Marc , Backen Alison , McNamara Mairéad G. , Hubner Richard A. , Barriuso Jorge , Gillespie Loraine , Lamarca Angela , Valle Juan W.
Published: April 2023

Introduction: Pancreatic exocrine insufficiency (PEI) in patients with advanced pancreatic cancer (aPC) is well documented, but there is no consensus regarding optimal screening. Methods and analysis: Patients diagnosed with aPC referred for palliative therapy were prospectively recruited. A full dietetic assessment (including Mid-Upper Arm Circumference (MUAC), handgrip and stair-climb test), nutritional blood panel, faecal elastase (FE-1) and 13C-mixed triglyceride breath tests were performed. Primary objective: prevalence of dietitian-assessed PEI (demographic cohort (De-ch)); design (diagnostic cohort (Di-ch)) and validation (follow-up cohort (Fol-ch)) of a PEI screening tool. Logistic and Cox regressions were used for statistical analysis. Results: Between 1 July 2018 and 30 October 2020, 112 patients were recruited (50 (De-ch), 25 (Di-ch) and 37 (Fol-ch)). Prevalence of PEI (De-ch) was 64.0% (flatus (84.0%), weight loss (84.0%), abdominal discomfort (50.0%) and steatorrhea (48.0%)). The derived PEI screening panel (Di-ch) included FE-1 (normal/missing (0 points); low (1 point)) and MUAC (normal/missing (>percentile 25) (0 points); low (2 points)) and identified patients at high-risk (2–3 total points) of PEI [vs. low-medium risk (0–1 total points)]. When patients from the De-ch and Di-ch were analysed together, those classified by the screening panel as “high-risk” had shorter overall survival (multivariable Hazard Ratio (mHR) 1.86 (95% CI 1.03–3.36); p-value 0.040). The screening panel was tested in the Fol-ch; 78.4% patients classified as “high-risk”, of whom 89.6% had dietitian-confirmed PEI. The panel was feasible for use in clinical practice (64.8% patients completed all assessments), with high acceptability (87.5% would repeat it). Most patients (91.3%) recommended dietetic input for all patients with aPC. Conclusions: PEI is present in most patients with aPC; early dietetic input provides a holistic nutritional overview, including, but not limited to, PEI. This proposed screening panel may help to prioritise those at higher risk of PEI, requiring urgent dietitian input. Its prognostic role needs further validation.