bluuebunny/crossref_metadata_2025 huggingface dataset:
Dirección y evaluación de políticas públicas en base a la evidencia: ¿dónde se encuentra la Administración General del Estado?
Authors: Varela Merino Begoña
Published: October 2022

La inteligencia institucional plantea una nueva visión del análisis de los datos para generar conocimiento y apoyar la toma de decisiones. Para gestionarla correctamente, la cadena de valor de los datos se debe encontrar amparada por un marco de gobernanza. En este trabajo se identifican los componentes requeridos para su aplicación y se destacan los beneficios y oportunidades de orientar las políticas públicas mediante la evidencia, así como los riesgos y obstáculos a afrontar. Se lleva a cabo, además, un repaso del contexto normativo nacional y europeo donde los datos pasan a ocupar un lugar primordial en la labor de la Administración Pública. Se analiza la existencia en la Administración General del Estado de unidades orgánicas, competencias y experiencias vinculadas al proceso de obtención y gestión de datos, su transformación en información y ésta en conocimiento. Con la investigación que se presenta, se concluye que hay evidencias que sitúan a la AGE en el camino de convertirse en una data-driven organization y se aportan unas propuestas de mejora para guiarla en el mismo.
The Mental Health of Male Sexual Minority Asylum Seekers and Refugees in Nairobi, Kenya: A Aualitative Assessment
Authors: Misedah-Robinson Lourence , Schick Vanessa , Ross Michael W. , Wambua Solomon
Published: October 2022

Very little information exists about the experiences of asylum seekers and refugees who are men who have sex with men (MSM). Therefore, this study explores the psychological distress of MSM asylum seekers and refugees in the Nairobi metropolitan area. We collected data using in-depth interviews transcribed verbatim, coded using NVivo 12 Plus, and analyzed using the six-step thematic analysis framework. Four major themes emerged from the study: psychological distress, traumatic stress symptoms, mental health care access, and coping strategies. Although we did not use any diagnoses, the results indicate that MSM asylum seekers and refugees share mental health problems with other refugees. However, MSM have specific needs that derive from their persecution based on their sexual minority status. The results confirm extant findings, as seen in the discussion, and encourage more research. Further research will inform collaborative, culturally sensitive, and targeted interventions that decrease adverse mental health outcomes for MSM asylum seekers and refugees in the Nairobi metropolitan area.
Comparisons with Greek as a Tool for Asserting the Prestige of the Castilian Language in Golden Age Spain
Authors: Stefanchikov Igor Vyacheslavovich
Published: October 2022

The article addresses the subject of the use of Greek in the apologiae for Castilian (Spanish) language, drawing upon the key Spanish scientific treatises, and literary texts of the Spanish Golden Age (end of the 15th — first half of the 17th centuries), which mention Greek in an attempt to assert the prestige of Castilian. Particular attention is paid to the judgments about Greek and native languages expressed in the works of A. de Nebrija, J. de Valdés, C. de Villalón, F. de Medina, A. de Morales, F. de Quevedo, G. Correas and other writers and thinkers. Most studies in the field have always been primarily focused on the comparisons of Romance languages with their “mother”, Latin, while the use of Greek in the apologiae for Castilian has been a less frequent topic of study. The author comes to a conclusion that Greek invariably acts as the highest reference point for the Spanish grammarians, philologists and thinkers (and as an arbitrator or, sometimes, an "ally" of Castilian), while the attitudes towards Latin evolve over the course of the 15th–17th centuries.
Words and Collocations Containing roots -gr(i)eg- (-gring-, -grec-, etc.), -helen-, -bizant- in Modern Spanish
Authors: Stefanchikov Igor Vyacheslavovich
Published: October 2022

The article addresses the subject of the semantics of Spanish words and collocations containing the roots -gr(i)eg- (-grec-, -gring-, etc.), -helen-, -bizant-, associated with Greece and with the Greek culture. The author analyzes the semantics and etymology of the words and expressions the way they are represented in the two most reputable explanatory dictionaries, Diccionario de la lengua española (DLE) and Diccionario de americanismos. In some cases, the usage of the selected units is described with reference to corpus data (Modern Spanish corpora — CREA and CORPES XXI). The study has revealed the presence of a significant proportion of “learned borrowings” (“cultismos”), which is explained by the importance of Ancient Greek and Byzantine culture for European civilization in general and for Spain in particular. It is stated that the semantic evolution of some vocabulary units was influenced by stereotypical ideas about Greece and the Greeks. In addition, the analysis of Diccionario de americanismos has shown some peculiarities of the usage of the words and expressions under analysis in Latin American Spanish (e. g. the more frequent use of “gringo” and its derivatives).
IDENTITY FORMATION AND ITS ROLE IN OPTIMAL HUMAN DEVELOPMENT: A PSYCHOBIOGRAPHICAL STUDY OF ARTIST JACKSON POLLOCK
Authors: Muller Toni , Stroud Louise
Published: October 2022

Celebrated artist Jackson Pollock challenged the concept of art by moving beyond paintbrush and easel to throwing paint across canvasses laid out on the floor, and using his entire body to create an abstract image. However, despite this capacity for originality, Pollockâ€™s life was bracketed by severe binge drinking, alcoholism, and emotional instability. The importance of identity formation for healthy development is illustrated by a psychobiographical study of Jackson Pollock. Pollockâ€™s difficulties in establishing a stable identity seemed to play an integral part in impeding a positive life course. The developmental theory of Erik Erikson was the lens through which Pollockâ€™s life was studied, with a focus on Eriksonâ€™s proposed fifth stage of development, Identity versus Role Confusion. From the study it emerged that it was largely the individuals who surrounded Pollock who shaped him into what they wanted him to be with Pollock lacking the stable sense of self to protect him from a society that treated both him and the art he poured himself into as a commodity to be celebrated and vilified on whim. Alcoholism would cause his death at the age of 44, when, while heavily intoxicated, Jackson Pollock drove his car into a tree.
Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis
Authors: Bogdanova Elena V.
Published: October 2022

Background. Psoriatic erythroderma is rare and one of the most severe forms of psoriasis characterized by involvement of 8090% of body surface area.
Aims. To compare clinical and demographic characteristics of patients with psoriasis, depending on presence of psoriatic erythroderma in medical history; to assess the association between psoriatic arthritis and a history of psoriatic erythroderma.
Materials and methods. Patients aged 18 years and older with a duration of psoriasis of 10 years, from the psoriasis patients registry were included.
Comparison of continuous quantitative variables was performed using t-test or MannWhitney U-test. The 2 test or Fisher's exact test was used to compare qualitative binary variables.
The odds ratio of psoriatic arthritis in patients with and without a history of psoriatic erythroderma was calculated, unadjusted and adjusted for other independent variables.
Results. The number of patients included in the analysis was 1,870. A history of psoriatic erythroderma (PE) had 227 (12.1%) of them. There were no significant differences in patient age at inclusion to the registry (47.1 13.1 years vs. 47.7 13.3 years), and prevalence of PE among men and women (12.6% vs. 11. 4%).
Higher prevalence of arterial hypertension (47.9% vs 32.7%), angina pectoris (6.4% vs. 1.9%), myocardial infarction (3.2% vs. 1.0%), biliary dyskynesia (14.3% vs. 3.9%), fatty liver (12.2% vs. 7.7%), cholelithiasis (8.6% vs. 3.6%), and toxic liver disease (2.2% vs. 0.5%) among patients with vs without history of PE was found.
Psoriatic arthritis was diagnosed in 67.0% patients with a history of psoriatic erythroderma. The odds of having psoriatic arthritis in patients with a history of psoriatic erythroderma were 4 times higher than in patients without erythroderma: 4.043 [2.9755.493]. When adjusted for sex, age, duration of psoriasis, and body mass index, the odds ratio and statistical significance were maintained: 4.064 [2.9395.619].
Conclusions. Compared to patients without PE those with a history of psoriatic erythroderma have a greater comorbidity burden: a higher prevalence of cardiovascular diseases, diseases of the liver and biliary tract. A significant association between psoriatic arthritis and a history of PE was established.
Evaluation of the effectiveness of a moisturizing cream as an adjuvant in the treatment of eczema: A preliminary real-world study report
Authors: Gala Monil Yogesh Neena , Muchhala Snehal , Rathod Rahul , Mane Amey , Bhagat Seema , Kotak Bhavesh
Published: October 2022

Objectives:

Eczema is a papulosquamous disease characterized by itchy, dry, rough, flaky, inflamed, and irritated skin on arms, inner elbows, backs of the knees, or head. Numerous skin conditions can be managed with the help of moisturizers. Venusia® Max is a moisturizing cream meant for eczema with a unique combination of four butters – shea, cocoa, mango, and aloe that act as emollients along with glycerin, propylene glycol, emulsifying wax, and cyclomethicone. The study’s objective is to assess Venusia® Max cream’s moisturizing efficacy when used as an adjuvant to the main line of treatment for eczema.

Material and Methods:

This monocentric, real-world setting study evaluates the effectiveness of Venusia® Max as an adjuvant, along with prescribed treatment in patients with eczema, versus prescribed treatment only (without Venusia® Max) as well as baseline. One hundred and twenty subjects enrolled in the study were divided in two groups: 1. Receiving Venusia® Max cream as an adjuvant, along with prescribed treatment and 2. receiving prescribed treatment only. The subjects were assessed for eczema area and severity index (EASI) scores, skin hydration using moisture meter-SC, transepidermal water loss (TEWL) using VapoMeter, and subject self-assessment of itching, cutaneous dryness, and burning sensation.

Results:

In the group with Venusia® Max cream, significant reduction in the EASI score, burning sensation, itching, and TEWL along with significant increase in skin hydration was observed when compared to baseline.

Conclusion:

Thus, Venusia® Max cream offers a novel and effective topical treatment for the dry skin of eczema patients.
SITUAÇÃO DE SEGURANÇA ALIMENTAR EM AGREGADOS FAMILIARES APOIADOS PELO PROGRAMA OPERACIONAL DE APOIO ÀS PESSOAS MAIS CARENCIADAS
Authors: GONÇALVES FERNANDES Ana Cristina , GERALDES RODRİGUES PEREİRA Ana Maria , GONÇALVES FERNANDES António José
Published: October 2022

Introdução: A insegurança alimentar é um problema complexo, multifatorial e uma grande preocupação no âmbito da saúde pública que tem sido drasticamente potenciada pela resposta social e económica associada à pandemia COVID- 19. Esta condição está associada a efeitos prejudiciais à saúde devido a situações como a ingestão alimentar inadequada e consequente surgimento de doenças crónicas, problemas de saúde mental, entre outros. Em particular, nas crianças, esta condição pode levar ao aparecimento de deficiências alimentares que limitam o seu desenvolvimento físico e cognitivo. Desta forma, pessoas com esta condição têm tendência a usar frequentemente o sistema de saúde, com um aumento consequente nas despesas nacionais de saúde. De forma a combater a pobreza e a exclusão social em Portugal, surge o Programa Operacional de Apoio às Pessoas Mais Carenciadas (POAPMC), que pretende através de apoio alimentar e/ou de bens de primeira necessidade e medidas de acompanhamento, potenciar a inclusão social das pessoas carenciadas. Os destinatários finais deste programa são aqueles que se encontrem em carência económica, isto é, numa situação de risco de exclusão social, por razões conjunturais ou estruturais, e cuja capitação seja inferior ao valor da pensão social, atualizado anualmente, por referência ao indexante dos apoios sociais. Objetivo: Diagnosticar a situação de segurança alimentar em agregados familiares apoiados pelo POAPMC. Métodos: Desenvolveu-se um estudo transversal, observacional e quantitativo baseado numa amostra de 71 pessoas beneficiárias do POAPMC. Foi aplicada uma escala relativa à situação de segurança alimentar composta por 14 questões fechadas, referentes aos últimos 3 meses. Para o tratamento estatístico dos dados recolhidos foi utilizado o programa IBM Statistical Package for the Social Sciences (SPSS) versão 27.0 para Windows. Foi feito o estudo descritivo dos dados, tendo-se calculado frequências absolutas e relativas para variáveis qualitativas. Resultados: A maioria dos individuos são do género feminino (69,0%) e tem idades compreendidas entre os 18 e os 64 anos (91,5%). A insegurança alimentar verificou-se em 74,6% dos inquiridos, 14,1% na forma grave, 22,5% moderada e 38,0% ligeira. Constatou-se, ainda, que 25,4% dos agregados familiares do POAPMC estão em segurança alimentar. Conclusões: A maioria da amostra de beneficiários apesar de serem apoiados pelo POAPMC encontram-se em situação de insegurança alimentar, nomeadamente numa situação ligeira de insegurança alimentar. Estes resultados demonstram que, se os beneficiários não fossem apoiados pelo POAPMC, possivelmente estariam em situações mais graves de insegurança alimentar, sendo necessário continuar a criar medidas que possibilitem a todos os indivíduos atingir a condição de segurança alimentar.
Decision support tools for grass-based fodder management on Walloon dairy farms: current adoption and perspectives
Authors: Battheu-Noirfalise Caroline , Froidmont Éric , Mathot Michaël , Stilmant Didier
Published: October 2022

Description of the subject. Many decision support tools (DSTs) have been developed to help dairy farmers optimally manage the high variability in the quality and availability of grass-based fodder, but their adoption rate remains low. Objectives. The objective was to characterize and understand the adoption rate of DSTs related to using grass-based fodder. Methodology. A sample of 61 Walloon (Belgium) dairy farmers responded to an online survey concerning their current use of 23 DSTs related to using grass-based fodder either directly (pasture or grassland) or indirectly (feeding or techno-economic), as well as barriers to and incentives for adopting them, their current interest in DSTs, and satisfaction with the guidance on using these DSTs. Results. Pasture management DSTs were used the least, even though farmers were the most interested in them. Farmers used simple indicators rather than software or automated tools. Farmers indicated that DSTs were too expensive and time consuming, even if they could ultimately save them time and money. Continuing education is lacking. Four types of users were identified who influence the use of DSTs: high user no grazing (H-NG), high user traditional or technical grazing (H-T/TG), low user traditional grazing (L-TG), and moderate user organic (M-ORG). Conclusions. Communicating with end-users during each step of DST development would help (1) identify the specific needs of a diverse set of dairy farmers and (2) develop DSTs that better correspond to their practices. More long-term guidance is required to inform farmers about existing DSTs and to transfer the knowledge required to use them.
Understanding Reactivity of Self-Assembled Monolayer-Coated Electrodes: SAM-Induced Surface Reconstruction
Authors: Lucas Francisco W. S. , Schwartz Daniel K. , Medlin J. Will , Holewinski Adam
Published: October 2022

Thiolate self-assembled monolayers (SAMs) are often used to modify surface properties, including catalytic activity. These SAMs can also induce reconstruction of some metallic surfaces. Here we show, through formation and subsequent removal of thiolate SAMs from Au polycrystalline electrocatalysts, that irreversible changes to the underlying metal surface can lead to significant changes in catalytic properties, irrespective of specific interactions that might occur between thiolate molecules and various reactants. Using underpotential deposition of Pb as a surface probe, we find that across a range of different thiolates, SAMs tend to increase the proportion of (111)-facets on Au, but they simultaneously increase the defect density upon these and other facets. These changes lead to delayed onset but higher maximum activity toward formic acid oxidation, which is interpreted in terms of both the density of appropriate active site ensembles and changes to the binding isotherm for site-blocking hydroxyl species. The impacts of reconstruction are further illustrated through measured shifts in selectivity for electroreduction of crotonaldehyde, with reconstructed catalysts changing the favored product from butanal to crotyl alcohol. Thus, complex surface reorganization may play a significant role in catalytic behaviors of thiol-coated SAMs as well.
Enantioselective Access to C-N Axially Chiral Isoquinolones via Dynamic Kinetic Transformation of Carbene Reagents: Unique Chiral Induction Enabled by Dual Role of the Catalyst
Authors: Wang Peiyuan , Wu Hongli , Zhang Xue-Peng , Huang Genping , Li Xingwei
Published: October 2022

Isoquinolones are important structural motifs in synthetic and medicinal chemistry. Reported herein is highly atroposelective access to C-N axially chiral isoqionolones via rhodium-catalyzed C-H activation of N-alkoxy benzamides and [3+3] annulation with imidoyl sulfoxonium ylides. The coupling system proceeded efficiently under mild and redox-neutral conditions with excellent functional group tolerance as a result of dynamic kinetic transformation of the ylidic coupling reagent (carbene precursor). Experimental and computational studies revealed a pathway of C-H activation, carbene insertion, and formal nucleophilic substitution-cyclization for this coupling system. In particular, the C-N cyclization is enantio-determining and occurs via an unusual rhodium-catalyzed -bond metathesis mechanism. The benzamide, the imidoyl sulfoxonium ylide, and the chiral catalyst each played a dual role. The amide functionality acts as a directing group as well as an electrophilic acylating group, and the imidoyl sulfoxonium ylide participated as a nucleophile-functionalized carbene reagent. Applications of representative products as potentially useful chiral ligands have also been demonstrated.
Erratum to “Independent gradient model based on Hirshfeld partition: A new method for visual study of interactions in chemical systems”
Authors: Lu Tian , Chen Qinxue
Published: October 2022

This erratum corrects independent gradient model based on Hirshfeld partition of molecular density (IGMH) proposed in our previous paper (J. Comput. Chem. 2022, 43, 539–555), and a brief analysis shows why IGMH based on incorrect implementation (inversed sign) of gradient of free-state atomic densities works surprisingly better for graphically representing interaction regions of chemical systems than based on mathematically correct implementation.
Machine learning full NMR chemical shift tensors of silicon oxides with equivariant graph neural networks
Authors: Venetos Maxwell , Wen Mingjian , Persson Kristin
Published: October 2022

The nuclear magnetic resonance (NMR) chemical shift tensor is a highly sensitive probe of the electronic structure of an atom and furthermore its local structure. Re- cently, machine learning has been applied to NMR in the prediction of isotropic chemi- cal shifts from a structure. Current machine learning models, however, often ignore the full chemical shift tensor for the easier to predict isotropic chemical shift, effectively ignoring a multitude of structural information available in the NMR chemical shift ten- sor. Here, we use an equivariant graph neural network (MatTEN) to predict full 29Si chemical shift tensors in silicate materials. The MatTEN model predicts full tensors to a mean absolute error of 1.05 ppm and is able to accurately determine the magnitude, anisotropy, and tensor orientation in a diverse set of silicon oxide local structures. When compared with other models, MatTEN outperforms the state-of-the-art ma- chine learning models by 47%. MatTEN also outperforms historic analytical models by 57% for isotropic chemical shift and 91% for anisotropy. The software is available as a simple-to-use open-source repository, allowing similar models to be created and trained with ease.
GULA DARAH PUASA DAN JUMLAH SEL BETA TIKUS DIABETES SETELAH PEMBERIAN TEMPE DAUN YAKON
Authors: Muninggar Jodelin
Published: October 2022

Diabetes mellitus adalah penyakit metabolik ditandai hiperglikemia dan berpotensi terjadi komplikasi kronis pada organ tubuh. Tujuan penelitian menghitung kadar gula darah puasa (GDP) dan jumlah sel Beta pankreas dengan metoda Immunohystochemistry (IHC) pada tikus Sprague dawley yang diinduksi Streptozotocin setelah pemberian tempe daun Yakon (Smallanthus sonchifolia). Sejumlah 40 tikus jantan Sprague dawley usia 11-12 minggu dibagi menjadi 8 kelompok secara acak. Kelompok normal tidak mendapatkan perlakuan apapun. Kelompok DM (diabetes mellitus) mendapat induksi Streptozotocin, namun tidak mendapat tempe daun Yakon. Setelah induksi Streptozotocin 35 mg/kgbb, kelompok perlakuan 1, 2, 3, 4, 5 dan 6, berturut-turut mendapat tempe mengandung daun Yakon dosis 200 mg (P1), 400 mg (P2), 800 mg (P3), tempe (P4), teh daun Yakon (P5) dan Metformin 500 mg (P6). Perlakuan diberikan 60 hari. Sebelum terminasi, tikus diambil darah untuk pemeriksaan kadar gula darah puasa. Setelah terminasi, pankreas diambil dan dibuat slide preparat metoda IHC serta dihitung jumlah sel Beta pankreasnya. Uji statistik dengan One-Way ANOVA dan uji korelasi Pearson menggunakan SPSS 19 dan p<0,05. Hasil penelitian menunjukkan GDP kelompok perlakuan P2 352 gr/dL terendah dibanding kelompok perlakuan lain. Sedangkan jumlah sel Beta pankreas, kelompok P2 (44) dan P3 (45) tertinggi dibanding kelompok perlakuan lain. Uji One Way ANOVA untuk kadar GDP kelompok normal-DM-P2 menunjukan bermakna (p=0,000). Uji One Way ANOVA untuk jumlah sel beta kelompok normal-DM-P2 menunjukan bermakna (p=0,048). Uji korelasi GDP dengan jumlah sel Beta Pankreas menunjukan kekuatan lemah (p=0,820; r=0,067). Pemberian tempe daun Yakon dosis 400 mg/kb BB mampu menurunkan GDP dan meningkatkan jumlah sel Beta pada tikus diabetes yang diinduksi Streptozotocin. Korelasi kadar GDP dengan jumlah sel Beta pankreas memiliki kekuatan yang lemah.
KARAKTERISTIK FISIKOKIMIA DAN ORGANOLEPTIK SELAI TIMUN SURI (Cucumis melo l var reticulatus naudin) DENGAN BERBAGAI KONSENTRASI GULA DAN CMC
Authors: Hidayat Irvan , Kristiani Endang Bekti , Haryati Sri
Published: October 2022

Penelitian untuk mengetahui pengaruh konsentrasi gula dan CMC pada selai timun suri, terhadap karakteristik sifat fisikokimia dan organoleptik selai timun suri yang dihasilkan.Mengetahui   perlakuan terbaik pada selai timun suri dengan konsentrasi gula dan CMC yang berbeda.Penelitian ini menggunakan rancangan acak kelompok (RAK) pola faktorial, dengan faktor A (konsentrasi gula) dengan 3 level (30%, 35%, 40%) dan faktor B (CMC) dengan

2 level (0,5% dan 0,75%). dan diulang 3 kali. Bahan yang digunakan adalah timun suri, gula,CMC dan asam sitrat. Variabel yang diamati adalah kadar air, pH, serat kasar viskositas, daya oles dan uji organoleptik (daya oles dan kesukaan).

Berdasarkan analisis sidik ragam (ANOVA) menunjukan bahwa konsentrasi gula dan CMC berpengaruh terhadap kadar air, serat kasar, viskositas, daya oles serta uji organoleptik dayaoles, tidak berpengaruh terhadap kesukaan. Perbedaan pengaruh perlakuan tidak disebabkan oleh  adanya  interaksi  tetapi  karena  pengaruh  faktor  A  (konsentrasi  gula)  atau  faktor  B (konsentrasi CMC).

Perlakuan yang terbaik adalah A3B1 yaitu selai pada  konsentrasi gula 40% dan CMC

 

0,5% menghasilkan selai timun suri dengan kadar air 18,53%, pH, 3,40% serat kasar 4,40%, viskositas 57,50 cP, daya oles 1,87mJ, serta skor mutu hedonik daya oles 3,33 (mudah dioleskan) dan kesukaan 3,73 (suka – sangat suka).
PENGARUH PENAMBAHAN SERBUK DAUN KELOR (Moringa Oleifera) TERHADAP SIFAT FISIK, KIMIA DAN SENSORI FRUIT LEATHER ALBEDO SEMANGKA
Authors: Samsudin Lutfi , Larasati Dewi , Fitriana Ika
Published: October 2022

Albedo semangka salah satu sumber pektin yang potensial, pektin merupakan komponen tambahan penting dalam industri pangan, kosmetik, dan obat-obatan, karena kemampuanya dalam mengubah sifat fungsional produk pangan seperti kekentalan, pengemulsi, dan pembentukan gel . Fruit leather dapat dibuat dari satu jenis buah atau campuran beberapa jenis buah-buahan. Pemanfaatan daun kelor sendiri selama ini hanya sebatas produk olahan yang mempunyai umur simpan pendek diantaranya sebagai sayur dan minuman, sehingga tidak semua orang dapat menikmati manfaat daun kelor, terutama masyarakat perkotaan. Tujuan dari penelitian ini adalah Mengetahui sifat fisik (tekstur) mutu kimia (kalium, kadar abu, karbohidrat dan serat) dan uji sensorik (tekstur dan rasa) tertentu pada fruit leather albedo semangka setelah ditambahkan serbuk daun kelor. Albedo dipisahkan dari kulitnya kemudian di potong kecil-kecil kecil lkemudian di timbang sesuai perlakuan lalu campurkan dengan gula 20, asam sitrat 0.1, dan serbuk daun kelor dengan formulasi 0, 0.5, 1, 1.5, 2 g, kemudian di cetak di loyang dengan ketebalan 1 cm, kemudian di panaskan di food dehydrator dengan suhu 60 selama 16 jam. Pengujian yang dilakukan meliputi kadar abu, kadar serat kasar, kalium, karbohidrat, tensil strength, dan organoleptik rasa dan tekstur. Hasil penelitian menunjukkan penambahan serbuk daun kelor dengan formulasi 0, 0.5, 1, 1.5, 2 g pada proses pembuatan fruitleather Albedo semangka berpengaruh (p<0,05) terhadap peningkatan kadar abu, Serat kasar, Kalium, Organoleptik (tekstur dan rasa) dan penurunan (Tekstur dan Karbohidrat), Penambahan serbuk daun kelor meningkatkan kadar abu fruitleather albedo semangka sebesar 0,70 %–0,91 %, Serat kasar sebesar 6,06 %–7,90 %, Kalium sebesar 154,49 mg–159,93 mg, cenderung menurunkan kadar Karbohidrat sebesar 72,21 % - 69,80 %, dan Tekstur sebesar 0,37 MPa – 0,06 MPa. Perlakuan terbaik pada penelitian ini adalah pada perlakuan P5 yaitu dengan kandungan kadar abu sebesar 0,91 %, Serat kasar sebesar 7,90 %, Kalium sebesar 159,93 mg, cenderung menurunkan kadar Karbohidrat sebesar 69,80 %, dan Tekstur sebesar 0,37 MPa– 0,06 MPa.
PENGARUH KONSENTRASI MALTODEKSTRIN TERHADAP KARAKTERISKTIK FISIKOKIMIA SERBUK EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume)
Authors: Ummah Maslikhatul , Kunarto Bambang , Pratiwi Ery
Published: October 2022

The purpose of this research is to know the effect of increasing the concentration of maltodextrin on the physicochemical characteristics of parijoto fruit (Medinilla speciosa Blume) extract powder by analyzing yield, solubility, color intensity, air content, and anthocyanin content. The experimental design used in this study was a Completely Randomized Design (CRD) with one factor and 3 replications. The studied factors were the concentration of maltodextrin in making powder from parijoto fruit extract which consisted of 6 treatments, they are: 5%, 10%, 15%, 20%, 25%, and 30%. If there is a significant difference between treatments, further testing is carried out with the Duncan test at 5% level. The results showed that the addition of maltodextrin had a significant effect on all parameters of parijoto fruit extract powder. The best anthocyanin powder from parijoto fruit extract was the concentration of maltodextrin 10%, anthocyanin content 2.68 ppm, yield 12.48%, solubility 79.96%, water content 4.22%, lightening level (L*) 55.05, redness level (a*) 18.10, and yellowness level (b*) 16.64.
Pemanfaatan Kacang Kedelai Sebagai Pengganti Ayam Dalam Pembuatan Penyedap Rasa
Authors: Maulana Alifatqul
Published: October 2022

Tujuan dari penelitian ini adalah untuk menciptakan perasa alami, sehat dan berbeda yang paling disukai responden. Dalam penelitian ini peneliti menggunakan uji deskriptif untuk mengetahui perbedaan penyedap rasa dari daging ayam dengan penyedap rasa dari kedelai menurut responden dan uji hedonik untuk mengetahui tingkat kesukaan terhadap sampel yang diberikan. Pengumpulan data tersebut kemudian diolah dengan menggunakan metode uji-T. Data dalam penelitian ini menggunakan data primer yang berasal dari kuesioner dan pengolahan data menggunakan software SPSS versi 23. Hasil penelitian menunjukkan bahwa Dari data hasil uji hedonik kategori rasa dan aroma penyedap rasa dari kedelai yang menggunakan kedelai 100% kurang dapat diterima oleh para responden hal ini mungkin disebabkan karena rasa dari produk perlakuan kurang gurih dan tidak memiliki aroma seperti pada penyedap rasa dari daging ayam yang menggunakan daging ayam 100%. Sedangkan dari kategori tekstur dan warna penyedap rasa dari kedelai yang menggunakan kedelai 100% dapat diterima oleh para responden, hal ini mungkin disebabkan karena warna dan tekstur dari penyedap rasa dari kedelai serupa seperti pada produk penyedap rasa dari daging ayam.
Karakteristik Sensori Kopi Arabica Dan Robusta Menggunakan Teknik Brewing Berbeda
Authors: Kinasih Anggraini , Winarsih Sri , Saati Elfis Anis
Published: October 2022

Kopi Arabica dan Robusta saat ini memiliki daya tarik terutama di kalangan coffee shop. Penelitian ini bertujuan untuk mengetahui daya terima panelis melalui uji organoleptik dengan perbedaan teknik brewing terhadap kopi Arabica dan Robusta. Hasil yang didapat dari hasil penelitian yaitu rendemen kopi Arabica lebih besar dibandingkan Robusta yaitu 0,9916 %. Berat biji per 100 gram yang didapat kopi Arabica sebesar 0,175 gr dan jumlah biji kopi Robusta sebanyak 669 biji. Perhitungan jumlah biji yang rusak kopi Robusta lebih banyak, yaitu 196 biji rusak dalam 1 kg. Pengujian citarasa dilakukan oleh 4 orang panelis terlatih seperti barista dan roaster dan 8 panelis lainnya dengan pengujian organoleptic dan cupping test. Hasil uji organoleptic terbaik secara keseluruhan (overall) oleh teknik brewing  yaitu teknik Vietnam Drip pada kopi Robusta dengan score 6 (sangat suka) dengan penambahan susu kental manis pada tekniknya.
Karateristik Sensori Keju Mozarella Selama Penyimpanan Suhu Rendah
Authors: Winarsih Sri
Published: October 2022

Keju mozzarella memiliki nutrisi baik, memiliki protein, lemak da kadar air yang tinggi kadar air yang tinggi akam menyebabkan keju mudah mengalami kerusakan secara mikrobiologis. Upaya pengawetan keju dengan pengemasan dan penyimpanan yang baik. Perlu dilakukan kajian jenis kemasan dan suhu penyimpanan terhadap mutu sensori keju mozzarella. Perlakuan yang dicobakan dalam penelitian ini adalah keju yang dikemas menggunakan plastic polypropilen dan aluminiumfoil, masing-masing disimpan pada suhu 4oC dan -10oC dan diamati oleh panelis selama tujuh hari terhadap tekstur, warna, aroma, rasa, dan keseluruhan/overall. data pengamatan di rata-rata dan dideskripsikan. Hasil menunjukkan bahwa kemasan plastic PP dengann suhu penyimpanan -10oC mampu mempertahankan mutu keju mozzarella selama penyimpanan.
Brain aquaporin-4 expression in the rat septic model (immunohistochemical study)
Authors:  Shulyatnikova T.V. , Tumanskiy V.O.
Published: October 2022

The study aimed to determine aquaporin-4 expression in different brain regions was performed in Wistar rats subjected to cecal ligation and puncture (CLP) septic model. The immunohistochemical study of aquaporin-4 was carried out in the sensorimotor cortex, white matter, hippocampus, thalamus and caudate nucleus/putamen regions between 20 and 38 h after CLP. From the 12th h after CLP all animals showed the progressive impairment of sepsis signs and therefore, 9 rats were euthanized between 20-38 h (“CLP-B”, non-survived); 11 animals survived up to 48 h (con­stituted “CLP-A”, survived). After operation, CLP-B group displayed regionally-specific dynamic increase in aquaporin-4 level in the brain mostly associated with astroglial capillary endfeet: by 23rd h in the cortex – 234.15%, by 24th h in the thalamus –129.47% and hippocampus – 101.36%, by 30th h in the white matter – 135.31% and by 38 h in the caudate/pu­tamen – 92.85%; with the highest increase in cortex: by 3.34 times. Heterogeneous and heterochronous aquaporin-4 elevation among brain regions indicates territories more and less susceptible for systemic toxic exposure in sepsis as well as points to diverse reactive responsiveness of local astroglial populations during specific time-period after CLP. The higher rates of aquaporin-4 in the cortex of non-survived animals in CLP model reflects the importance of aquaporin-4 increase in the mechanisms of sepsis decompensation.
Features of the daily profile of blood pressure, taking into account polymorphism of the angiotensin II type 1 receptor gene in patients with arterial hypertension after myocardial infarction
Authors: Kolesnyk T.V. , Fursa O.V.
Published: October 2022

The article presents the results of a study of the daily blood pressure profile, taking into account the polymorphism of the angiotensin II type 1 receptor gene in patients with arterial hypertension with past myocardial infarction. The study involved 36 men with stage III hypertension, grade 1-3 arterial hypertension, with past myocardial infarction. The average age in the study group was 57.0 (52.0; 64.0) years, the experience of hypertension was 6.3 (4.0; 15.0) years. The average period after a heart attack was 48.0 (12.0; 144.0) months. The study of the type 1 angiotensin II receptor gene on the DNA-sorb-B test system was carried out by the polymerase chain reaction method with the restriction of products by endonuclease. 24-hour blood pressure monitoring was performed according to the standard method. It was found that, in general, in the group, the levels of systolic and diastolic blood pressure according to the median corresponded to the target ones. But the blood pressure load indicators both for the day and separately during the day and at night exceeded the normal range. In an intergroup analysis, significantly higher blood pressure figures and pressure load indices were registered in patients with the CC genotype of the angiotensin II type 1 receptor gene. In addition, this group of patients showed a high incidence of adverse variants of circadian fluctuations in blood pressure. In accordance to the daily monitoring data, only 13 (34.2%) patients achieved the target level of blood pressure: with the AA genotype – in 6 (15.9%) patients, with the AC genotype – in 6 (15.9%) patients and in 1 (2.6%) patient with CC genotype of the angiotensin II type 1 receptor gene. In 4 (10.5%) patients with the AA genotype and in 3 (7.9%) patients with the AC genotype of the angiotensin II type 1 receptor gene, achievement of the target level of blood pressure was registered in the normal range of blood pressure load indices. In other cases, the target level of arterial pressure was accompanied by an increase in pressure load indices, which indicates incomplete daily control of arterial hypertension.
Should renal resistive index be considered as a routine predictor in newly diagnosed acute hydronephrosis in patients with unilateral renal colic?
Authors: Dahmarde Hamid , Fazeli Faramarz
Published: October 2022

Urinary tract stones are the most common causes of urinary tract obstruction, leading to patient hospitalization in the emergency room. This study is aimed to evaluate the use of the mean resistance index (mRI) to predict hydronephrosis in patients admitted for acute renal colic. This prospective study was performed on 100 patients who were admitted to the emergency department (ED) with unilateral renal colic (RC) problem. At the first visit, the following was done for all patients: 1. blood was taken from them for laboratory studies; 2. ECG and cardiological test; 3. plain film of the urinary tract; 4. аbdominal US; 5. bilateral color doppler ultrasound (CDUS) with renal RI measurement. Based on the information collected at different times during the experiment, patients were divided into two groups: the group that showed signs of dilatation (group A) and the group with hydronephrosis (group B). The obtained data were analyzed statistically by SPSS version 20. A mRI with a 0.68 cut off value was the most accurate (AUC:0.878), and Sensitive (90%) cut-off value for prediction of  hydronephrosis development among patients presenting with RC and renal stone. This cut-off value also provided the highest positive (94%) and negative (76%) predictive values. CDUS with RI measurement is an easy and non-invasive method that provides useful information about urinary tract obstruction stones in patients with unilateral RC. In our study, this method was able to predict successfully the onset of acute renal dilatation. This was done with different levels of sensitivity, specificity, accuracy and diagnostic efficiency that were higher than ultrasound. Daily use of CDUS in ED can improve ultrasound, especially when other methods are contraindicated. For example, the methods by which the patient is exposed to radiation (pregnancy, allergies, renal failure, etc.) or intravenous injection of contrast agents (urography and CT).
Clinical and pathogenetic prediction of the dynamics of the course of psychoses in epilepsy
Authors:  Nosov S.G. , Yuryeva L.М. , Shusterman T.Y. , Nekrasova O.V.
Published: October 2022

Transient epileptic psychoses in 30-40% of cases turn into psychotic states with a long, paroxysmal or chronic course. The objective of this article is to conduct a systematic analysis of modern literature sources to clarify the factors, clinical and pathogenetic patterns of transformation of transient (short-term) epileptic psychosis into psychotic states with prolonged and chronic course, as well as to identify pathogenetically oriented principles of treatment of such patients. The prognostic value of clinical and neurophysiological factors regarding increasing of the psychotic process duration has been noticed, clinical patterns of transformation of short-term psychosis into long-term (changes in the dynamics and structure of psychosis, features of the relationship with organic personality disorder and dementia in epilepsy, as well as epileptic seizures) have been shown. A number of important neurophysiological pathogenetic mechanisms of increasing the psychosis duration (growing cerebral hypofrontality, temporal localization and regular spread of the epileptic process) have been identified. Pathogenetically oriented principles of treatment tactics of patients with epileptic psychoses have been described and analyzed taking into account the revealed regularities of increasing of their duration.
Charactirestics of vitamin D level in patients with atopic dermatitis
Authors: Garibeh E. , Bondаr S.А. , Tokarchuk N.I. , Vyzgha Y.V.
Published: October 2022

The peculiarity of the skin is that it acts not only as a place of synthesis of vitamin D, but also as an organ targeted for its biologically active form. The aim of our study was to analyze the level of vitamin D in patients with atopic dermatitis. There were examined 48 people aged between 18 to 55 years; they are residents of Vinnytsia and Vinnytsia region. Serum levels of vitamin D, total IgE and  eosinophilic cationic protein (ECP) were determined in the subjects. The average level of vitamin D in the serum of patients with atopic dermatitis was 19.2 [11.3-25.4] ng/ml, which corresponded to a deficiency. Among those surveyed, vitamin D deficiency was found in 68.4±4.7% (n=26) while vitamin D insufficiency in 31.6±4.5% (n=12). The severe course of the disease prevailed among patients aged 18-40 years (63.33±8.79) % more than in the age group of 41 years and older, (36.67±8.8%, p<0.05; OR=2.98, S=0.53, 95% SI:1.04-8.52). The proportion of people with vitamin D deficiency and moderate severity of atopic dermatitis was 62.5% (n=10) with a median level of 14 [8.3–19] ng/ml, and patients with severe atopic dermatitis made up 90.9% (n=20) (χ²=4.6; p=0.023), in which the median level of vitamin D was 14 [8.3-19] ng/ml. Serum vitamin D levels were in the zone of deficiency in patients with moderate and severe atopic dermatitis. Vitamin D deficiency was significantly more common in the group of patients with elevated levels of allergic inflammation markers. A positive correlation of medium strength between the level of vitamin D and ECP in the serum of patients with atopic dermatitis (rs=0.53, p<0.001), was revealed.
Opium use and COVID-19 infection, a retrospective study in Iran
Authors: Afshari Mahdi , Shahramian Iraj , Salarzaei Morteza , Mirzaie Hadi , Parooie Fateme
Published: October 2022

The situation of Covid-19 patients with opium consumption has not been comprehensively investigated especially in Iran. This study is aimed to investigate the effect of current opium addiction on the severity and outcome of the Covid-19 infection. During a retrospective cohort study, clinical, demographic and all variables related to the severity and death due to the Corona virus infection were collected from the medical records of patients hospitalized from February 2020 to June 2021 in the study area. The role of current addiction in the severity and outcome of the disease was investigated using Cox, logistic and linear regression models. Of 939 confirmed Covid-19 cases admitted during the study period, 70 (7.5%) patients were currently addicted.  Multivariate reg­ression models showed that current opium addiction significantly increased the chance of endotracheal intubation (OR=2.96, p=0.005) and reduced the mean length of stay in hospital (beta coefficient =-0.42, p<0.0001). However, opium addiction did not change the risk of death (HR= 1.54, p=0.063) or O2 saturation (OR=1, p>0.99). Opium addiction can be associated with the severity of Covid-19 infection, but does not play a considerable role in the mortality of the patients.
Hygienic assessment of the potential risk for public health caused by groundwater and surface water pollution by pesticides of various chemical classes
Authors:  Korshun M.M. , Martіianova Y.V.
Published: October 2022

The aim of the study was to compare the potential danger for human health caused by pollution in both underground and surface water sources with the fungicide pydiflumetofen and herbicides amicarbazone and bicyclopyrone in a wide range of soil-climatic conditions. Three methods were used: determination of the integral hazard vector (R); predicting the negative impact of pesticides on the health of the population by integral groundwater contamination hazard index (IGCHI), and a comprehensive risk assessment of the negative effects of pesticides on human body, when they are washed out into water (Р). It was found that the highest level of danger for public health due to possible pollution of water sources, is inherent in bicyclopyrone regardless of the soil-climatic conditions and the used assessment method (R=144.6-173.2 – very high potential hazard; IGCHI=12 points – extremely dangerous for humans, 1А class). Pydiflumetofen has a high potential integral vector hazard (R=115.8-137.5) and simultaneously by the value of the IGCHI (7-9 points) can be assessed from dangerous (2 class) to highly dangerous (1B class) for humans, depending on soil-climatic conditions. Amicarbazone by IGCHI (11 points) is extremely dangerous for humans (1A class), and at the same time by the integral vector (R=76.8-122.5) its potential danger varies from medium to high, depending on the soil-climatic conditions. Assessing the risk of the investigated pesticides, based on the comparison between potential exposure and the permissible daily intake it was concluded that the potential risk of adverse effects on public health (P) of all investigated substances is acceptable.
Place of injuries of elbow joint in the structure of primary permanent disability among Ukrainian population
Authors:  Naumenko L.Y. , Zub T.O. , Mametyev A.O.
Published: October 2022

Despite the rapid development of orthopedics consequences of elbow injuries have a significant proportion of unsatisfactory treatment results until now. Owing to comprehend the sources of disability doctors could determine drawbacks of treatment and regulate rehabilitation program for patients with elbow injuries better. The purpose of the study was to investigate the structure of primary permanent disability due to elbow injuries among the Ukrainian population. The study was made on annual reports of Regional centers of medical and social expertise and the Center of medical and social expertise of the city of Kiev for 2018. During the reporting period a disability group due to upper extremity injuries was established totally for 1 211 patients in age over 18 years, among them 195 people had consequences of elbow traumas. That caused an intensive prevalence rate of 6.22 cases per 1 million of adults. Male patients (70.8%) and patients in working age (94.9%) prevailed among people with disability. 10.8% of patients were determined as people with disability without a revision period after the primary examination on medical and social expertise commission. The causes of primary permanent disability were domestic injuries (90.8%), occupational injuries (5.0%), injures during military service and battle injuries (2.1%) and disability since the childhood (2.1%). Structure according to disability groups showed the next distribution: 90.3% – the 3rd group, 9.2% – the 2nd group and 0.5% – the 1st group. Consequences of elbow injuries which led to primary permanent disability were caused by bone fractures (61.5%), elbow contractures and elbow ankyloses (19.0%), injuries of an ulnar nerve (8.7%), traumatic amputation at the elbow level (6.2%), forearm dislocations (3.1%), open wounds of elbow (1.0%), elbow ligaments ruptures (0.5%). Patients registered as disabled with a revision period during the first examination on commission had sufficient rehabilitation potential for restoration of elbow joint function and one of the upper limb in total.
Clinical case of leptospirosis in a woman against chronic alcohol intoxication
Authors: Sydorchuk А.S. , Sоrokhan V.D. , Bоhachyk N.А. , Drahanush А.D. , Fеldman I.V. , Hrubliak L.V.
Published: October 2022

An interesting clinical case of leptospirosis infection in an elderly woman with a professional way of getting infection on the background of alcohol abuse has been described. The authors emphasized the clinical features of this bacterial zoonosis, considered aspects of differential diagnosis of leptospirosis with other common infectious diseases. It has been emphasized on the intricacies of a detailed epidemiological anamnesis taking in order to identify and evaluate biorisk factors for pathogenic leptospira con­tami­nation in a particular occupational environment. It has been pointed out the necessity of a complex laboratory-instrumental investigation in the infectious hospital, since the delay of hospitalization and adequate treatment can worsen the prognosis for a favorable outcome of the clinical case and recovery. Such specific laboratory methods for verifying leptospiras in the blood of patients as a reaction of microagglutination and lysis with a kit of leptospira and bacterioscopic examination of a smear in the dark field are of high sensitivity and specificity and therefore are widely used in clinical practice.