bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Flipped Classroom Teaching on EFL Learners' Language Achievement and Anxiety During Hybrid Covid-19 period
Authors: YEGANEHPOUR Parisa
Published: December 2023

During the global COVID19 pandemic, education has moved from the classroom to an online or hybrid format. No matter how much the new system's education and training models are based on online models, the pandemic affects students' learning. In order to construct a novel assessment design for an urgent online or hybrid courses, researchers must examine students' language use and attitudes throughout the epidemic period. Due to the negative feelings and emotions such as anxiety that many learners experience in the classroom, the current study aims to the effect of flipped classroom teaching approach on EFL learners’ language achievement and language anxiety. Sixty EFL intermediate university students took part as participants. The anxiety questionnaire FLCAS adopted from Horwitz, Horwitz, and Cope (1986), a pre-test and a post-test were administered to the students during a semester consisted of 14 weeks to study the effect of flipped classroom on participants’ language anxiety and achievement. The obtained information was statistically analyzed and the statistical results showed a significant and positive effect of flipped learning on students' motivation and anxiety on hybrid pandemic period.
Görsel Sanatlar Öğrencilerinin Bakışıyla Okulda Bir Gün: Storyboard Uygulaması
Authors: ARSLAN Suzan
Published: December 2023

Storyboard bir hikâyenin bir dizi panele ayrı ayrı resimlenmesini ifade eder. Araştırmada, Resim-İş Öğretmenliği Grafik Tasarım VI Anasanat atölye dersinde “okulda bir gün” konulu storyboard uygulamasından yola çıkılmıştır. Araştırmanın amacı, Resim-İş Öğretmenliği Grafik Tasarımı VI Anasanat Dalı öğrencilerinin okula bakışları çerçevesinde, okulda bir gün konulu storyboard çalışmalarıyla ilgili görüşlerini ortaya koymaktır. Bu araştırmada nitel araştırma yöntemi benimsenmiştir. Katılımcılar dördüncü sınıf Resim-İş Öğretmenliği Grafik Tasarım VI dersini alan altı öğrenciden oluşmaktadır. Veriler, öğrencilerin storyboard çalışmaları ve yarı-yapılandırılmış görüşmeler aracılığıyla toplanmıştır. Araştırmanın verileri tümevarımsal olarak analiz edilmiştir. Analiz sonucunda “okula bakış açısı”, “okul yaşantısının görselleştirilmesi” ve “storyboard deneyimine yönelik görüşler” olarak üç ana tema ve alt temalar elde edilmiş ve bu yönde bulgulanmıştır. Araştırma sonucunda, öğrencilerin okulu meslek kazandıran, geleceğe hazırlayan, kendine yetebilmeyi öğreten ve hayatlarında devamlı yer alan bir kurum olarak gördükleri ortaya çıkmıştır. Öğrenciler günlük okul yaşantılarını genel olarak; sabah hazırlık- okula gelme- sınıf/atölyede ders- kantin/yemekhanede yemek yeme-sınıf/atölyede ders- çıkış biçiminde ana hatlarıyla görselleştirdikleri ve okulun biçimsel organizasyonunun yansıttıkları görülmüştür. Okul yaşantısına dair storyboard uygulamasının öğrencilerde okul yaşantısını düşündürdüğü ve tasarımsal olarak deneyim elde ettikleri sonucuna ulaşılmıştır. Ortaya çıkan sonuçlar alanyazın ve benzer araştırmalarla tartışılmış ve bu doğrultuda çeşitli öneriler sunulmuştur.
Uzaktan Eğitim Sürecinde Özgün Baskı Resim Dersine İlişkin Öğrenci Görüşlerinin İncelenmesi
Authors: ŞEN Şevval Nur , AYKAÇ Vesile
Published: December 2023

Günümüz iletişim olanaklarının, küreselleşmenin ve bilgi teknolojilerinin de hızla gelişmesinin sonucunda, hem eğitim-öğretim hem de sanat alanlarının doğal olarak etkilendiği görülmekte, dolaylı olarak da bu alanlar içerisinde yeni arayışlar ortaya çıkmaktadır. Alternatif eğitim olanakları, geleneksel ortam ve teknikleri yeni, deneysel yaklaşımlarla bağdaştırma, uygulama alanlarında yeni yöntemsel arayışlar gibi yaklaşımlar oluşum göstermektedir. Bu bağlamda günümüz teknolojileri sayesinde çeşitli iletişim araçları kullanılarak zaman ve mekândan bağımsız eğitimin yürütülebildiği çağdaş ve yenilikçi eğitim sistemi olarak ifade edilebilecek uzaktan eğitim kavramı çıkmaktadır. Covid-19 pandemi dönemi içerisinde bakıldığında, uzaktan eğitimin, eğitim-öğretim işleyişinin devam edebilmesi adına, bir kurtarıcı olduğu varsayılmakta ve bahsedilen alternatif eğitim ortamlarının uygulanmasına olanak sağladığı görülmektedir. Bu dönem içerisinde teorik derslerin uzaktan eğitim ile işlenebildiği gibi uygulamalı derslerin de işlendiği görülmekte ve bu derslerin de bir arayış içinde oluşuna rastlanmaktadır. Ortaya çıkan arayış durumu ile geleneksel eğitim ortamlarındaki değişim, uygulama alanında da hem eğitim vermekte olan hem de eğitim görmekte olan bireylerin var olan yaklaşımlarında değişikliğe gitmelerine yol açmıştır. Bu araştırmada uzaktan eğitim sürecinde işlenmiş olan Özgün Baskı Resim dersinin süreç içerisindeki öğrenci yorumlamaları ele alınmakta ve aktarılmaktadır. Araştırmanın çalışma grubunu İnönü Üniversitesi Eğitim Fakültesi Güzel Sanatlar Eğitimi Bölümü Resim-İş Öğretmenliği Programı 4. sınıf öğrencileri oluşturmaktadır. Araştırma sonucunda öğrencilerin özgün baskı resim dersini atölye ortamlarından uzakta gerçekleştirmiş olmaları ve bu nedenle teknik ve materyal kullanımlarında söz konusu olan değişikliklere ilişkin görüşleri, görüşme formu ve yarı yapılandırılmış görüşme tekniği kullanılarak incelenmek istenmiştir. Bu inceleme sonucunda karşılaşılması hedeflenen sonuçların sanat eğitimi ve lisans düzeyi özgün baskı resim atölye eğitiminde öğrencilerin daha yaratıcı üretimler yapmalarına yardımcı olacağı öngörülmektedir.
Bilişim Teknolojileri Formatör Öğretmenlerinin Okul Yöneticilerinin Görüşleri Doğrultusunda Değerlendirilmesi
Authors: KAZU Hilal , AKTAŞ Ali
Published: December 2023

Günümüzde bilim ve teknoloji alanında meydana gelen gelişmeler eğitim alanında da önemli etkiler meydana getirmiştir. Bu etkiler eğitim paradigmalarında değişime neden olmuş, salgın hastalık, savaş ve deprem gibi durumlar nedeniyle uzaktan eğitim gibi uygulamalar yaygınlaşmıştır. Bu durumda eğitimde teknoloji kullanımı ve entegrasyonu önem kazanmış, bilişim teknolojileri formatör öğretmenlerine olan ihtiyaç artmıştır. Bu araştırmada, etkileşimli tahtaların bakım ve onarımları ile ilgili öğretmen ve öğrencilere rehberlik için görevlendirilen bilişim teknolojileri formatör öğretmenlerinin okul yöneticilerinin görüşleri doğrultusunda değerlendirilmesi amaçlanmıştır. Araştırma nitel araştırma yöntemlerinden olgu bilim deseninde tasarlanmıştır. Bu araştırmada, Malatya ili Yazıhan ilçesindeki ortaokullarda görev yapmakta olan yöneticiler arasından belirlenen sekiz okul yöneticisi ile görüşmeler yapılmıştır. Araştırmada, araştırmacılar tarafından geliştirilen ve altı sorudan meydana gelen görüşme formu kullanılmıştır. Araştırma verilerinin analizinde betimsel analizi tekniği kullanılmıştır. Araştırma sonucunda, bilişim teknolojileri formatör öğretmeni olarak görevlendirilen öğretmenlerin ‎büyük bir kısmının farklı branşlardaki öğretmenlerden meydana ‎geldiği, BT formatör öğretmeni olarak görevlendirilecek öğretmenlerin BT öğretmeni branşında olması gerektiği, Farklı okullara yapılan görevlendirmeler sonucunda okulda öğretmen yetersizliği, ders programını yapma ve ders görevlendirmelerinde sorunlar yaşandığı, BT formatör öğretmenlerinin özellikle teknolojik bilgi ve teknolojik araç ve gereçlerin bakım ve onarımı konusunda gerekli yeterliklere sahip olmadıkları, teknolojik araç ve gereçlerin bakım ve onarımı için teknik elemanın görevlendirilmesi gerektiği sonuçlara ulaşılmıştır
The Contribution of the System Justification to Social Cohesion
Authors: Agadullina E.R. , Lavelina D.I.
Published: December 2023

Objective. Analysis of the contribution of the system justification to social cohesion.
Background. Social cohesion in Russia, as well as around the world, is declining, despite its beneficial impact on the society. In accordance with the System Justification theory, there is reason to assume a connection between the system justification and social cohesion, but no empirical verification has been carried out.
Study design. The study examined the relationship between the system justification and different levels of social cohesion. The study used the system justification scale and measurements of variables of interpersonal trust, density of social relationships, openness, social participation, institutional trust and legitimacy of institutions. The presence and nature of the relationship was verified through correlation analysis and structural equation modeling (SEM).
Participants. 819 Russians (52% of women) from 18 to 83 years old (M = 37,7; SD = 10,7).
Measurements. Russian-language versions of the scales of system justification by J. Jost. G. Bottoni's model of social cohesion.
Results. The model of social cohesion was successfully tested on a Russian sample, but macro-level variables cannot be separated and do not allow the formation of the second factor of the model by type of measurement (objective and subjective). System justification significantly predicts all levels of social cohesion. The regression model showed that the more people tend to justify the system, the more they trust others, get involved in various group interactions and positively evaluate the institutional activities.
Conclusions. The system justification significantly positively predicts social cohesion at the micro, meso and macro levels.
The Role of Ideological Beliefs and Tolerance for Uncertainty in Seeking Esoteric Services
Authors: Antonova N.A. , Eritsyan K.Y. , Usacheva N.M.
Published: December 2023

Objective. Assessing the relationship between the use of esoteric services, tolerance for uncertainty and beliefs unpredictability and determinism.
Background. Esoteric practices today represent a significant market sector worldwide and in Russia. At the same time, predictors of use of such services are still poorly studied. Most psychological research has focused on beliefs in the paranormal or supernatural, while much less attention has been paid to associated behavioral practices.
Study design. Cross-sectional survey study.
Participants. Adult population of Russia (N = 1498, 47% males). A quota sample of an online panel was used to represent the adult population of Russia in terms of gender and age composition and representation of the urban and rural population. Mean age 41,6 years old (SD = 12,72).
Measurements. Russian-language versions of tolerance to uncertainty (MSTAT-I) and belief in freedom/determinism (FAD-Plus) scales, assessment of socio-demographic and behavioral parameters using survey methods.
Results. Seeking esoteric services is associated with a range of beliefs about determinism and unpredictability and is more common among women and people with high religiosity. Contrary to the hypothesis put forward, no relationship was found between seeking esoteric services and tolerance of uncertainty.
Conclusions. Seeking esoteric services is closely related to beliefs about the world: belief in determinism (both fatalistic and scientific) may be a facilitator of the use of such services, while beliefs in unpredictability and freedom are negatively associated with the use of such services.
Development of Domestic Economical Psychology Issues in Scientific Work of A.L. Zhuravlev
Authors: Drobysheva T.V.
Published: December 2023

Objective. The purpose of this article is to analyze the spectrum of issues developing by the academician of the Russian Academy of Sciences and of the Russian Academy of Education A.L. Zhuravlev himself and to consider the questions elaborating under his guidance – with his co-workers and students in different periods of his scientific work; the research was conducted from the perspective of analyzing the processes of formation and development of the domestic economic psychology problem field.
Background. The existing rules of development of socio-economic systems, in particular their cyclical nature (alternation of stable and crisis periods, uneven changes in the system), indicate the actuality of historical and psychological research in the field of economic psychology in order to predict economic, psychological and socio-psychological dynamics in changing geopolitical and socio-economic conditions of society.
Results. Changes in the management of country’s economic life in the 80s of the last century, the subsequent economic transformations in society, crises and global processes in the world economy are considered as social factors that actualize the research of socio-psychological and economic-psychological phenomena in the scientific work of A.L. Zhuravlev. Among them are: psychological readiness of the population for cardinal economic changes, the relationship of socio-psychological and economic dynamics, patterns and mechanisms of economic socialization and economic self-determination, psychological resources of economic development of society and other phenomena.
Conclusions. Three main stages in the development of the issues of domestic economic psychology presented in the scientific work of A.L. Zhuravlev was reveled. The connection of the studied economic-psychological and socio-psychological phenomena with the socio-economic dynamics of public life is shown.
A Case of Disseminated Coccidioidomycosis
Confirmed by Skin Biopsy in Korea
Authors: Yoon Yi Na , Lim Ji Won , Son Hyung Seok , Cho Young Ah , Lee Yang Won , Choe Yong Beom , Yu Da-Ae
Published: December 2023

Disseminated coccidioidomycosis is an uncommon fungal infection primarily observed in immunocompromised individuals. Infection typically occurs when individuals inhale fungal spores in endemic areas such as the southwestern United States and parts of Central and South America. However, globalization has increased the number of reported
cases outside endemic areas. Herein, we present an unusual case of coccidioidal meningitis, a rare but fatal complication of disseminated coccidioidomycosis, in an immunocompetent patient who previously resided in an endemic area.
Subcutaneous Basidiobolomycosis: A Rare and
Underdiagnosed but Curable Fungal Infection -
A Case Report
Authors: Christi Yoana Fransiska Wahyuning , Citrashanty Irmadita , Widia Yuri , Anggraeni Sylvia , Astari Linda , Edbert Daniel , Kawilarang Arthur Pohan , Ervianti Evy
Published: December 2023

Basidiobolomycosis is a rare deep fungal infection caused by Basidiobolus ranarum and characterized by the development of swollen erythematous nodular lesions. Several azoles have been shown to be an effective treatment for this condition. Herein, we report a case of basidiobolomycosis that was initially misdiagnosed as a different disease and resolved after itraconazole medication. A 25-year-old man presented with a 2.5-year history of extensive swelling on his right arm, face, and neck. Initially, he was diagnosed with lipoma and scapular tuberculosis; however, no improvements were observed post-surgery and with tuberculosis medication. Histopathological examinations revealed giant cells, aseptate hyphae, and the Splendore-Hoeppli phenomenon. Fungal culture confirmed the
isolate to be Basidiobolus ranarum. The patient was given oral itraconazole 200 mg twice daily, and the complete resolution was achieved after 25 months of treatment.
Manejo del tiempo en estudiantes de medicina paraguayos
Authors: Maidana-Pont Ema , Barrios Iván , Maqueda-Amarilla Violeta , Marcet Franco Igor Ernesto , Torales Julio
Published: December 2023

Introducción: la gestión eficiente del tiempo se erige como una competencia cardinal entre los estudiantes de Medicina. Esta destreza resulta imperativa, dado que les habilita para administrar sus agendas de forma eficaz, evitando así el estrés inherente a su formación y asegurando un desempeño exitoso, mejorando así el equilibrio entre sus compromisos académicos y personales al adoptar decisiones pertinentes, tales como la priorización efectiva de tareas y la prevención de situaciones de sobrecarga que puedan menoscabar su rendimiento. Metodología: estudio observacional descriptivo, de prevalencia y asociación cruzada, temporalmente prospectivo, realizado en estudiantes de Medicina de Paraguay, con el fin de determinar el manejo de su tiempo. Para medir el manejo del tiempo se usó la versión en español de la Time Management Behavior Questionnaire for University Students que es un instrumento autoadministrado que integra 34 ítems relacionados con la forma en que los estudiantes manejan su tiempo de aprendizaje y estudio. Resultados: la correlación entre las variables cuantitativas demostró relación entre edad y la subescala “establecimiento de objetivos y prioridades” (r= -0,208; p=0,038), siendo esta asociación indirecta y débil. En cuanto a diferencia de medias, se encontró relación entre sexo y la subescala “herramientas de gestión del tiempo” (t=-2,37; gl=98; p=0,020), observándose que los hombres (2,61 ± 0,89) tenían una media menor que las mujeres (3,04 ± 0,74). Conclusiones: el aspecto que obtuvo la puntuación más baja fue la preferencia hacia la desorganización. Esta característica, contrastada con la alta puntuación otorgada al establecimiento de metas y prioridades, señala una tendencia hacia un enfoque de aprendizaje estructurado y ordenado, procurando así evitar la carencia de planificación en las actividades.
Asociación entre cronotipo y síntomas depresivos: un estudio exploratorio
Authors: Rolón-Méndez Elías , Franco-Palacios Aldo , Barboza-Basualdo Sebastián , Zapattini-López Juan Esteban , O’Higgins Marcelo , Navarro Rodrigo , Ruiz Díaz Noelia , Amarilla Diego , Barrios Iván , Torales Julio
Published: December 2023

Introducción: el cronotipo es la predisposición natural de cada individuo a experimentar picos de energía o momentos de descanso en función de su ritmo circadiano. Los individuos pueden tener cronotipos matutinos, vespertinos o intermedios, que pueden tener relación con el desarrollo de depresión. Objetivo: determinar la existencia de asociación entre el cronotipo y la sintomatología depresiva en una muestra de adultos. Metodología: este estudio observacional, descriptivo y exploratorio se realizó en agosto de 2023. Se incluyeron en este estudio adultos de ambos sexos. Se recolectaron datos sociodemográficos, y los participantes respondieron el Morningness-Eveningness Questionnaire de Horne y Östberg para evaluar el cronotipo, y el Patient Health Questionnaire de 2 ítems (PHQ-2) para evaluar los síntomas depresivos. Se utilizaron estadísticas descriptivas para todas las variables. Para la estadística inferencial, se utilizó la prueba de chi-cuadrado con un nivel de confianza del 95 %. Se utilizó odds ratio para cuantificar las relaciones. Resultados: un total de 105 personas participaron en el estudio, de las cuales el 58 % eran mujeres. La edad media de la muestra era de 29,4 ± 11,6 años. El 69 % de la muestra presentaba el cronotipo matutino, mientras que el 31 % presentaba el cronotipo vespertino. Se observó que el 31 % de los participantes puntuaba positivamente para depresión (PHQ-2 ≥ 3). Se encontró una relación entre el cronotipo y los puntos de corte del PHQ-2 (p=0,036). Se halló una OR=2,5 (IC 95%: 1,05-5,95) a favor del cronotipo vespertino para el desarrollo de depresión. Conclusión: casi siete de cada diez participantes tenían un cronotipo matutino, mientras que tres de cada diez dieron positivo en depresión. Los individuos con cronotipos vespertinos son más propensos a desarrollar síntomas depresivos que aquellos con cronotipos matutinos.
Fungal Keratitis. Part 2. Diagnosis and Treatment
Authors: Shilovskikh O. V. , Ponomarev V. O. , Timofeev V. L.
Published: December 2023

The problem of diagnosis and treatment of fungal keratitis (FK) is very acute. Due to the slow development of clinical features and the absence of clear pathognomonic signs, this disease is characterized by a late start of the introduction of adequate etiotropic therapy. Often this leads to the development of large corneal defects requiring surgical intervention. Diagnostic methods are divided into invasive and non-invasive. Invasive methods include the study of scrapings from the surface of the cornea from the site of ulceration, biopsy of the corneal stroma or moisture of the anterior chamber using microscopic, cultural methods or polymerase chain reaction (PCR). Non-invasive techniques include confocal microscopy and optical coherence tomography of the anterior segment. They allow you to dynamically monitor the course of the pathological process and the response to ongoing therapy. Promising methods are also the detection of (1,3)-β-D-glucans in tears, the detection of the pathogen using MALDI-TOF MS. The gold standard for the treatment of FK in the world is the topical application of 5 % Natamycin (approved by the FDA, but not available in Russia). Fluconazole, Voriconazole and Amphotericin B, available in Russia, are also widely used, but their topical use is possible only in off label format. In the presence of hypopyon or an increase in the size and depth of the infiltrate, despite ongoing treatment, immediate surgical treatment is required in order to preserve the integrity of the eyeball. Such treatments include penetrating keratoplasty, anterior lamellar keratoplasty, amniotic membrane transplantation, conjunctival flaps, corneal collagen cross-linking (with unproven efficacy), and argon laser. A promising method for the treatment of FK can be the use of Ag(10 %):InP/ZnS MPA quantum dots as monotherapy or as a bioconjugate with known antifungal drugs.
Limbal Epithelial Stem Cells Transplantation in Cases with Unilateral Limbal Stem Cell Deficiency Syndrome
Authors: Malyugin B. E. , Borzenok S. A. , Nefedova O. N. , Gerasimov M. Yu.
Published: December 2023

This review presents well-known surgical techniques aimed at the treatment of unilateral limbal insufficiency syndrome. Among the many available techniques, one should especially highlight the so-called “simple limbal epithelial transplantation”, which has proven to be an effective, safe and generally available method of treating unilateral limbal insufficiency syndrome (SLN). It should be noted that the risks of recurrence of SLN remain significant, and the mechanisms of engraftment of transplanted limbal epithelial stem cells on the recipient’s eye are not fully understood. The review also considers options for new promising approaches to the possible solution of existing problems in the transplantation of limbal epithelial stem cells.
Dry Eye Syndrome in Refractive Patients. Literature Review
Authors: Doga A. V. , Borzenok S. A. , Mushkova I. A. , Karimova A. N. , Obraztsova M. R. , Khubetsova M. Kh. , Ostrovskiy D. S.
Published: December 2023

Dry eye syndrome is a multifactorial disease of the ocular surface, which is based on the development of hyperosmolarity, inflammation and sensorineural disorders in the imbalance of the structural components of the tear film. The main complaints of refractive patients after keratorefractive surgery are a feeling of dryness in the eyes, a foreign body, redness, blurring of the image, which is due to the clinical manifestations of post-refractive dry eye syndrome. There are factors that contribute to the development of postrefractive dry eye syndrome, such as: neurotrophic epitheliopathy, postoperative inflammation, damage to goblet cells, toxic corneal epitheliopathy caused by preservatives contained in eye drops, leading to inadequate restoration of the tear film. In clinical practice, to assess the stability of the tear film, a method is used to determine the tear film rupture time using invasive and non-invasive methods. Invasive methods include: staining of the ocular surface with a solution of fluorescein during the Norn test. To date, laboratory diagnostics expands the understanding of the pathogenesis, etiology and mechanisms underlying the xerosis of the ocular surface at the molecular level, and also facilitates the diagnosis and prognosis of dry eye syndrome. Laboratory methods of the ocular surface include the study of biomarkers of lacrimal fluid, conducting impression cytology with an assessment of the condition of goblet cells. In this regard, it is necessary to have a deep understanding of the main etiopathogenetic links of dry eye syndrome, a wide range of diagnostics of the condition of the ocular surface before and after the surgical stage of patient management, which will determine the success of keratorefractive surgery and a stable course of the postoperative period.
Genetic Epidemiology of Primary Congenital Glaucoma in the World. Part I
Authors: Oganezova Zh. G. , Kadyshev V. V. , Egorov E. A.
Published: December 2023

To understand the current situation with the genetic epidemiology of primary congenital glaucoma (PCG) in the world, as well as to identify genotype-phenotype correlations, 87 publications were analyzed from the Pubmed and elibrary databases, mainly the latest 5 years. This publication presents the first part of the analysis, covering Arab and African countries, Turkey, the USA, Brazil, Australia and New Zealand. The second part of the review, which will be published in early 2024, will focus on data from East and South Asia, Western Europe and Russia. The highest incidence of PCG is typical for Arab countries, which is associated with the presence of a significant number of consanguineous marriages in these countries. In most countries, boys predominated among patients with PCG, and the process was often bilateral. In Australia female patients predominate. The PCG phenotype is more severe in patients with CYP1B1 mutations (early onset, bilateral involvement) than in patients without mutations, and in patients with consanguineous parents than in children from unrelated marriages. Among the genetic causes of PCG in different populations, the most common (from 30 to 86 % of cases) in Arab countries, Brazil and Turkey are mutations in the CYP1B1 gene. The spectrum of mutations varies depending on the region. In Australia and New Zealand, biallelic mutations were identified in the CYP1B1, CPAMD8 and COL18A1 genes, as well as heterozygous mutations in the TEK, FOXC1 and ANGPT1. Mutations in rare genes were also found in patients with PCG from Lebanon (ANGPT1 (p.K186N), Mauritania (NTF4 (c.601T>G, p.Cys201Gly) and WDR36 (c.2078A>G, p.Asn693Ser)). In the USA, the influence of the thrombospondin gene (THBS1) on the development of PCG is being studied. Based on the results of genetic and epidemiological studies, specific treatment, rehabilitation and preventive programs can be developed, which will determine the success of PCG therapy in children, preserving their visual functions.
Optimization of Platelet-Rich Plasma Fraction Selection for Surgical Treatment of Macular Holes
Authors: Kazaykin V. N. , Demchenko N. S. , Kleimenov A. Yu.
Published: December 2023

Objective: based on clinical and morpho — functional analysis of retinal restoration and assessment of the cellular composition of platelet-rich plasma, to determine its optimal fraction for surgical treatment of macular hole. Materials and methods. This study presents the results of 120 cases of surgical treatment of eyes with macular hole. The patients were divided into 2 groups. In the 1st group (60 eyes), the technology developed in our clinic was used without the use of postoperative tamponade of the vitreal cavity and the use of autologous platelet-rich plasma (PRP), in the 2nd — traditional technology for the treatment of macular hole s (60 eyes). The cellular composition of the PRP of 30 patients was analyzed. Results. 2 months after surgery, 119 patients had the restoration of all retinal layers in the macular hole area and positive dynamics of visual acuity was recorded in comparion with the preoperative period. After observation for 6 months after surgery, cases of recurrence of macular hole were not detected. Conclusion. The therapeutic value of BoTP lies in the tamponing and regenerative effect. According to the results of this study, for maculrupture surgery, it is rational to use plasma from a layer of pure platelet-rich plasma (P-PRP), which contains a sufficient number of platelets capable of having a positive therapeutic effect, and a minimum number of leukocytes capable of performing the functions of immune protion and repair of the retiand surrounding tissues.
Pathomorphological Changes of the Retina in Chronic Intraocular Pressure Increase
Authors: Zhigalskaya T. A. , Krivosheina O. I. , Khazhieva V. P.
Published: December 2023

Glaucoma is one of the most unfavorable neurodegenerative diseases of the eye. However, the etiology and pathogenesis of glaucoma have not been fully studied enough. Thus, for example, the issue of the primacy of damage to the fundus structures in the development of glaucomatous optic neuropathy remains debatable.This review presents a modern view of the main pathomorphological changes in the retina in chronically elevated intraocular pressure (IOP). The analysis of structural changes in various layers of retinal tissue, primarily retinal ganglion cells in glaucoma, is carried out. Attention is focused on the role of various pathogenetic mechanisms in the occurence and progression of dystrophic changes in the retina with an increase of IOP. The need for a comprehensive analysis of structural, functional and hemodynamic parameters in each specific clinical case is emphasized, which helps to increase the sensitivity of new methods for diagnosing glaucoma and optimize the treatment of the disease.
Investigation of Blood Supply to the Macular Region of the Retina in Chronic Myeloproliferative Diseases
Authors: Yunusova E. M. , Mukhamadeev T. R. , Bakirov B. A. , Idrisova G. M.
Published: December 2023

Chronic myeloproliferative diseases (CMPD) are tumor diseases of hematopoietic tissue with increased proliferation of one or more lines of myelopoiesis. Quite often with this pathology there are find references to damage to the organ of vision. With CMPD changes in the composition of peripheral blood are observed, leading to changes in the rheology of blood and contributing to the deterioration of microcirculation of eye tissues. In addition, abnormal proliferation of hematopoietic cells and prolonged specific therapy weaken the body’s immune system, contributing to the development of systemic inflammation. These processes can lead to deterioration of blood supply to eye tissues, in particular in the macular region. Purpose. To evaluate vessel density (VD) in the superficial and deep vascular plexuses of retina and the area of foveolar avascular zone (FAZ) using optical coherence tomography with angiography function (OCTA) in patients with CMPD. Patients and methods. The study included 25 patients with CMPD (50 eyes) and 20 volunteers (40 eyes), comparable in gender and age, without a history of hemoblastosis. All the examined patients underwent comprehensive ophthalmological diagnostics, including OCTA. Results. According to the results, patients with CMPD revealed a significant decrease in VD in all sectors (except the foveolar zone) in both studied vascular plexuses, as well as a significant increase in area of FAZ compared to the control group. Conclusion. A decrease in VD in the vascular plexuses of the retina, as well as an increase in area of FAZ, are signs of deterioration of retinal blood supply and retinal ischemia. It is possible that these changes may lead to violations of blood rheology, as well as chronic systemic inflammation observed in patients with CMPD. Deterioration of blood flow and prolonged retinal hypoxia can contribute to serious visual impairment of patients. In this regard, patients with CMPD require more detailed monitoring, possibly with correction of the main treatment.
The First Results of a Full Loading Dose of Brolucizumab in the Treatment of DME
Authors: Amirkulieva R. N. , Khomyakova E. N. , Loskutov I. A.
Published: December 2023

The aim of the study was to evaluate the efficacy and safety of brolucizumab in the Russian population of patients with diabetic macular edema. Patients and methods: 41 patients (29 women and 12 men) with diabetic retinopathy and diabetic macular edema of comparable age were included in the study. The patients were divided into 2 groups depending on the previous DME treatment. The first group included 24 patients (24 eyes) who had not previously received treatment: 9 men and 15 women, the average age of patients was 62.9 ± 9.3 years, the average best-corrected visual acuity was 0.40 ± 0.23, CTS 332 ± 87 microns, MV 9.65 ± 1.2 mm3. There were 17 patients (17 eyes) in the second group, they had previously received other antiangiogenic drugs, but retained the activity of the disease against the background of the treatment (1 man and 16 women), the average age of patients was 60.6 ± 8.3 years, the average best-corrected visual acuity was 0.40 ± 0.27, CTS 351.6 ± 149.0 microns, MV 9.3 ± 1.8 mm3. All patients received at least 5 intravitreal injections of brolucizumab (205 injections in total) at intervals of 6 weeks. The control examination was carried out 6 weeks after the last injection and a month after the fifth injection. The best-corrected visual acuity, intraocular pressure, central retinal thickness (CTS), macular volume (MV) were evaluated according to optical coherence tomography. Results. In the first group, a statistically significant increase in the best-corrected visual acuity was revealed from 0.40 ± 0.23 to 0.575 ± 0.27 (p = 0.05), the indicators of CTS and MV statistically significantly decreased. In the second group, only a decrease in CTS was detected, while the indicators of BCVA and MV did not show statistically significant changes. Conclusion. Patients with DME, who were treated with brolucizumab and who had not previously received treatment with other drugs, showed an improvement in anatomical and functional parameters, patients, who retained the activity of the disease against the background of the treatment, showed a slight decrease in the activity of the disease.
Possibilities of Preservative-Free Therapy for Primary Open-Angle Glaucoma
Authors: Antonov A. A. , Vitkov A. A. , Dorofeev D. A. , Volzhanin A. V.
Published: December 2023

Purpose: To compare the effectiveness of trabeculectomy and evaluate the change of the state of the tissues of the anterior segment of the eye in patients with long-term use of preservative and non-preserved hypotensive therapy before surgery. Patients and Methods. The study was conducted in a group of 30 patients (30 eyes) aged from 58 to 77 years with uncompensated primary openangle glaucoma, who were admitted to the glaucoma surgery. The patients were divided into 2 groups depending on the hypotensive regimen used before surgery: group I - patients who used preservative-containing local hypotensive drugs; Group II - patients who used Traviolan© and other non-preservative hypotensive drugs before antiglaucoma surgery. At the initial examination, the collection and analysis of patient complaints, visometry, tonometry, and biomicroscopy of the structures of the anterior segment of the eye were performed. Patients complaints were assessed on the OSDI test questionnaire. The study of total tear production was investigated using the Schirmer test. The tear film break time study investigated the Norn test. Observation and re-examinations were performed a week, 1 month and 3 months after trabeculectomy. Results. A week after glaucoma surgery, there was a short-term deterioration in the parameters by which dry eye disease (DED) was assessed: in group I, OSDI was 11.8 ± 3.3, Schirmer and Norn tests — 5.3 ± 1.3 mm and 4.3 ± 1.0 sec, respectively. In group II OSDI was 10.7 ± 3.5, Schirmer and Norn tests were 8.2 ± 2.2 mm and 4.7 ± 1.3 sec, respectively. After 1 and 3 months, the DED indicators improved, more pronounced in group I: after 1 and 3 months, OSDI was 12.9 ± 3.7 and 12.9 ± 4.2, respectively; Schirmer’s test — respectively, 7.4 ± 1.9 and 7.0 ± 1.8 mm; Norn’s test — 5.1 ± 0.8 and 5.2 ± 0.9 sec. In group II, 1 and 3 months after trabeculectomy, OSDI was 12.4 ± 3.0 and 12.4 ± 2.4. Schirmer’s test was 9.9 ± 2.1 and 9.5 ± 1.7 mm, Norn’s test was 5.5 ± 1.2 and 5.5 ± 1.3 sec, respectively. At all follow-up periods, except for week 1, there was a significant intergroup difference between the studied parameters of dry eye disease (p < 0.05). Conclusion. Long-term use of preservative-containing hypotensive therapy contributes to the development of chronic toxic-allergic conjunctivitis, which affects the long-term prognosis of trabeculectomy and the quality of life associated with DED. One of the ways to minimize such negative effects is the use of preservative-free drugs in the selection of glaucoma therapy. The use of a preservative-free form of travoprost is justified due to its high selectivity for FP-prostanoid receptors, which ensures high efficiency and less side effects. The improvement in DED parameters associated with cancel of therapy after surgery is more pronounced in the group of patients who initially took preservative-free drugs.
Efficacy and Safety of Chronic Blepharitis Treatment
Authors: Yanchenko S. V. , Malyshev A. V. , Teshaev Sh. Zh. , Petrosyan L. M. , Ramazonova Sh. Sh.
Published: December 2023

Purpose: to evaluate the netilmicin efficacy and safety in chronic blepharitis treatment. Methods: 30 posterior or mixed chronic blepharitis (CB), meibomian gland dysfunctions (MGD) and dry eye (DE) patients were examined. All patients received 0.3 % netilmicin (Nettacin; instillations, 3 times a day) and 0.3 % netilmicin (Nettavisk; applications, at night) for 14 days. Evaluated: integral indicator of СB subjective symptoms (II-SS, scores); integral indicator of CB objective signs (II-OS, scores); OSDI (scores); tear film brake up time (TBUT, s); lower tear meniscus height (LTMH, µm; OptoVue); Bijsterveld`s xerosis index (XI, scores); Korb`s MGD severity (MGD-S, scores). Control points: 1 — when included in the study, 2 — 15 days of observation. The criteria for the therapy effectiveness included the II-OS and II-SS positive dynamics, and the safety criteria included the absence of significant negative dynamics of OSDI, TBUT, LTMH, XI, MGD-S. Statistics: M ± s calculation, Wilcoxon t-test (differences were considered significant at p < 0.05). Results. At the 2nd control point, there was a statistically significant decrease in II-SS (from 3.62 ± 0.49 to 2.47 ± 0.50) and II-OS (from 3.58 ± 0.50 to 2.45 ± 0,50). Also, at the 2nd control point, a significant decrease in OSDI was recorded (from 35.40 ± 3.59 to 26.40 ± 3.06) and insignificant trend towards a decrease in LTMH (from 325.10 ± 21.26 to 319.80 ± 41 26), an increase in XI (from 5.10 ± 0.40 to 5.23 ± 0.50), an increase in TBUT (from 5.47 ± 0.57 to 5.63 ± 0.56) and a decrease in MGD-S (from 2.16 ± 0.38 to 1.97 ± 0.18). Conclusion. As a result of the use of 0.3 % netilmicin, a significant decrease in the severity of CB symptoms and signs was noted, which indicates a good clinical effectiveness of the therapeutic effect. At the same time, the absence of significant negative dynamics of indicators characterizing the state of the ocular surface (OSDI, TBUT, LTMH, XI, MGD-S) during therapy indicates the safety of using 0.3 % netilmicin for the CB treatment in conditions of comorbidity, including MGD and DE.
Possibilities of Preservative-Free Therapy for Primary Open-Angle Glaucoma
Authors: Yanchenko S. V. , Malyshev A. V. , Teshaev Sh. Zh. , Petrosyan L. M. , Boboeva R. R. , Juraeva G. B.
Published: December 2023

Purpose: to evaluate the efficacy and safety of preservative free travoprost generic in primary open-angle glaucoma patients. Patients and methods. 40 patients with compensated primary open-angle glaucoma (POG) and dry eye (DE) were examined: 1st group (20 patients) with the initial stage of POG (travoprost with a preservative monotherapy), 2nd group with an advanced stage of POG (travoprost with a preservative in combination therapy). In all patients, travoprost with a preservative was replaced with preservative free travoprost (Traviolan, 1 time per day, in the evening). Control: 1 — when included in the study; 2 — 4 weeks after replacing travoprost with a preservative for preservative free travoprost. Efficiency criteria: absence of negative dynamics of intraocular pressure (IOP) and MD and PSD perimetric indices (dB; Optos). Safety criteria: absence of OSDI (scores), tear film brake up time (TBUT; Norn’s test, s), lower tear meniscus height (LTMH, µm; OptoVue) and Bijsterveld’s xerosis index (XI, scores) negative dynamics. Results. At the 2nd control point, all observed did not have a statistically significant dynamics of IOP, MD, PSD. In patients of both groups, at the 2nd control point, there was the OSDI and TBUT statistically significant positive dynamics, and in patients of the 1st group — XI statistically significant positive dynamics. The trend towards to XI decreasing in 2nd group patients and the LTMH dynamics in both groups turned out to be statistically insignificant. Conclusion. Preservative free travoprost has shown efficacy comparable to that of travoprost with preservative in both monotherapy and combination therapy. Significant positive dynamics of OSDI and TBUT in patients of both groups and XI in 1st group patients after switching to preservative free travoprost indicates a good “safety profile” of therapy in terms of its effect on the ocular surface state in DE conditions, which, from our point of view, may contribute to maintaining the “quality of life” and patients compliance.
Pleitbezorger van de voetbalkijker: Het discours over voetbal op televisie in de Nederlandse dagbladen tussen 1950 en 1980
Authors: Vallinga Mark , Harbers Frank , Broersma Marcel
Published: December 2023

Between 1950 and 1980, television in the Netherlands became a mass medium, which attracted a large audience, in part by broadcasting football matches and news. Scholars have theorised how the rise of a new medium creates anxiety and feelings of rivalry with established media as they are confronted with a new competitor. This paper focuses on this premise by examining to what extent and how such feelings of rivalry between television and newspapers are part of the metadiscourse on football and television within the ranks of Dutch dailies between 1950 and 1980. Based on the results of this qualitative discourse analysis, this paper argues that newspapers certainly discussed the rise of football coverage on television, but did not show any signs of being afraid that television would offer a harmful competition. Much rather, in defending the right to free news gathering as well as the interests of the audience, newspapers positioned themselves by and large as great supporters of football coverage on television.
Tracing Farmers’ Entrepreneurship and Communication Skills Using a Bibliometric Approach
Authors: Emi Widiyanti  , Cahyadin Malik , Padmaningrum Dwiningtyas , Suminah Suminah , Utari Prahastiwi
Published: December 2023

Farmers’ entrepreneurship and communication skills have been widely discussed in the literature. However, mapping the linkages and comparisons between the two needs to be addressed more. Therefore, this study attempts to map the literature on the two topics. The literature documents were collected from the Scopus database from 2012 to 2022. A bibliometric approach was employed. The findings revealed that literature documents on farmers’ entrepreneurship outnumbered those on farmers’ communication skills. The Journal of Sustainability and Journal of Rural Studies published the highest number of literature documents on the two topics. The highest number of literatures on farmers’ entrepreneurship was elaborated in developing countries, while that of farmers’ communication skills was studied in developed countries. Therefore, scholars and policymakers in developing and developed countries faced challenges in raising the number of literature documents on farmers’ entrepreneurship and communication skills to enhance agricultural business for both old and young generations.
Risk Analysis on the Cassava Value Chain in Central Lampung Regency
Authors: Suryani Ani , Masyhuri Masyhuri , Waluyati Lestari Rahayu , Utami Arini Wahyu
Published: December 2023

The Central Lampung Regency is the center of cassava production in Lampung Province, the Indonesia’s largest cassava-producing province. Cassava has much promise; however, various risks arise throughout the value chain. Risks in the agricultural sector, including cassava farming, are unavoidable and severely impact stakeholders and consumers. This study aimed to identify the risks and the most effective mitigation measures for the cassava value chain. This research was conducted using the House of Risk (HOR) method, divided into two phases: HOR 1 and HOR 2. It involved 286 samples encompassing 263 farmers, six traders, three tapioca industries, eight non-tapioca industries, and six financial institutions. The risks were determined through the Supply Chain Operational Reference (SCOR) model. The results unveiled several priority risks in the cassava value chain, consisting of unpredictable weather changes, scarcity of fertilizers, the absence of farming standards, limited capital, delivery technical problems, price fluctuations, negligence of the workforce, default credit, and lack of customer or farmer knowledge leading to confusion. Furthermore, the risk mitigation actions covered preventing the risks of cassava farming; applying appropriate technology; utilizing production, marketing, and financing system assistance; preventing the risks of cassava trading business; implementing a structured market system; developing access to financing, institutions, and markets; developing marketing infrastructure; developing adaptive farming; monitoring during the credit period; socializing risk management to employees; and providing institutional, financing, and production assistance.
Relationship of maternal serum zinc level with gestational diabetes mellitus
Authors: Tamanna Tabassum , Mahmood Sharmeen , Nasrin Begum , Das Tripti Rani
Published: December 2023

Background: Gestational diabetes mellitus (GDM) is a prevalent pregnancy disease in Bangladesh that poses risks to the health of both mother and fetus. Glycosuria-related nutritional deficiencies are often associated with GDM. Zinc, an essential micronutrient, plays a central role in insulin-mediated glucose metabolism and storage. Because of its importance in insulin-related processes, zinc deficiency is potentially relevant to pregnancy-related carbohydrate intolerance. The aim of this study was to evaluate the relationship of maternal zinc deficiency with gestational diabetes mellitus.
Methods: This case-control study, conducted from October 2020 to September 2022, involved 160 pregnant women aged 18-35 from the Department of Obstetrics and Gynecology, BSMMU, Dhaka. Of these, 80 women diagnosed with GDM (24-40 weeks gestation) and 80 matched healthy controls were included in our study.
Results: The mean (SD) zinc level was much lower in the cases than in the controls (59.60±19.37 µg/dl and 91.84±38.19 µg/dl, respectively; p-value = <0.001). There was a significant negative correlation of serum zinc levels with both FBG (r=-0.406, p<0.001) and 2HABG (r=-0.381, p<0.001). The likelihood of developing gestational diabetes was approximately 4.2 times higher in mothers with low serum zinc (<68 g/dL) than in mothers with zinc levels of 68 g/dL (p<0.001; OR=4.214; 95%- CI=2.158-8.231).
Conclusions: Low maternal serum zinc levels have been found to be associated with gestational diabetes mellitus. Therefore, the serum zinc level can be used as a predictor to determine the risk of developing gestational diabetes mellitus.