bluuebunny/crossref_metadata_2025 huggingface dataset:
Todo el hombre razona: la dimensión implícita de la inferencia en John Henry Newman
Authors: Briones Rodrigo
Published: May 2023

John Henry Newman (1801-1890), quien ha ejercido una enorme influencia intelectual en el desarrollo de la teología católica en los siglos XIX y XX, es menos conocido por sus aportes a la filosofía. Indagando en su obra filosófica por antonomasia, An Essay in Aid of a Grammar of Assent (1870), proponemos delinear la concepción newmaniana de inferencia, mostrando especialmente cómo el autor desarrolla una original propuesta acerca del funcionamiento implícito del razonamiento. A través del examen de nociones como la inferencia informal, la inferencia natural y el sentido ilativo, pretendemos justificar que no son pocos los elementos por los que Newman puede ser considerado plenamente un filósofo, en cuanto contribuye ampliamente a una teoría del conocimiento que rehabilita una razón para la vida y existencialmente contextualizada.
El hombre: un problema o un misterio en Gabriel Marcel
Authors: Viteri Bazante Frank Bolívar , Ramírez Giraldo Cesar Augusto
Published: May 2023

El presente trabajo pretende visualizar la comprensión ontológica de Marcel, a partir de la realidad antropológica desprovista de sentido para proyectarse a una comprensión del ser en sí mismo en todas sus categorías ontológicas y vitales, no solo desde la lejanía metafísica sino también como realidad vital que incide sobre todo en la definición de sentido. El ser que Marcel presenta es abierto, no un objeto que se pueda reducir a una visión objetiva como lo hace el ser humano en su deseo de conocer. La experiencia del Ser es una condición profunda y metafísica del ser humano que trasciende a la visión objetiva de la realidad e invita a pensarse desde la profundidad de la condición humana. El hombre ya no solo se entiende como el sujeto que acontece en la realidad objetiva sino que se encamina a encontrarse en la subjetividad como espacio de encuentro con el Ser. Tomando en cuenta el desarrollo conceptual y dialógico de la encíclica Fides et ratio que da luces para comprender el problema del silencio y el misterio. De ahí que la relación ontológica se constituye en fundamento de la existencia a partir del “yo soy”. Para después comprender que la definición del ser no es una categoría mental como tal, sino más bien una estructuración a partir de la vivencia concreta en relación con el ser.
Identification and Synthesis of Process-Related Impurities in Lisdexamfetamine
Dimesylate
Authors: Mandavkar Sagar , Gole Pradip , Pawar Rushikesh , Deshmukh Vishal , Kishore DVP , Bonde Nilesh L. , Kotharkar Sandeep A. , Joshi Sunil V.
Published: May 2023

During the process optimization of Lisdexamfetamine dimesylate, two process impurities
were observed.

Methods:

These impurities remained a concern for commercialization and were isolated, on characterization,
were found to be H-Lys-ε-Lys-d-amphetamine and other being its regio- isomer H-Lys-α-Lysd-
amphetamine. The main target of this study was to synthesize reference compounds for HPLC analysis
of these impurities produced in Lisdexamfetamine.

Result:

To the best of our knowledge, these impurities are not commercially available and no synthetic
methods have been reported. Both of these potential impurities were synthesized, and their structures
were established by various spectral techniques.

Conclusion:

Furthermore, herein we also report the synthesis of two process impurities Boc-
Lys(Boc)-ε-Lys(α-Boc)-O-Nitrophenol and Boc-Lys(Boc)-α-Lys(ε-Boc)-O-Nitrophenol and their fate
for the formation of impurities H-Lys-ε-Lys-d-amphetamine and H-Lys-α-Lys-d-amphetamine.
Variant regression modeling of electricity production in the Russian Federation
Authors: Noskov S. I. , Popov E. S. , Seredkin S. P. , Tirskikh V. V. , Toropov V. D.
Published: May 2023

Objective. The aim of the study is to build a linear regression model of electricity generation in the Russian Federation depending on resource indicators, which include: the volume of coal and gas production, the production of fuel oil. Statistical data for 2005 - 2020 were used as the information base of the study.

Method.Estimation of unknown parameters of the linear model is carried out using three methods - least squares, modules and anti-robust estimation. They behave differently with respect to outliers in the data. The second of them does not react to outliers at all, completely ignoring them, and the third, on the contrary, strongly gravitates towards them, therefore, these methods are a kind of antagonists in relation to each other.

Result.Three alternative models of a linear regression model of electricity production with high accuracy are obtained. The value of the parametric stability index of the data sample, based on the properties of the parameter estimation methods, is calculated. Observations are identified that correspond to the maximum and minimum extent to the linear model on the analyzed sample. The values of the contributions of the factors to the right parts of the models are calculated.

Conclusion.Three versions of the model built by different methods can be successfully used to solve problems related to forecasting the production of electricity in the country. At the same time, the variant constructed by the least squares method is a kind of compromise.
Algorithm for monitoring the dynamic zone of forest fires by a group of unmanned aircraft
Authors: Tebueva F. B. , Antonov V. O. , Kabinyakov M. Yu. , Svistunov N. Yu.
Published: May 2023

Objective. The aim of the study is to develop an algorithm for monitoring forest fire zones, carried out by unmanned aerial vehicles (UAVs).

Method. The study is based on methods of algorithmic support, methods of analysis and synthesis of automated control systems for technological objects.

Result. The technologies and methods for monitoring forest fires are considered, which confirms the relevance of the use of UAVs to perform these tasks. An algorithm for the use of UAV swarms for monitoring forest fire zones is presented. The algorithm includes enlarged stages of decomposition of the global problem, distribution of tasks, application of methods of collective decision-making, etc.

Conclusion. The proposed algorithm can be implemented subject to the development of swarm control theory.
Living Standards and Wellbeing in Africa, an Economic History Perspective
Authors: Bolt Jutta
Published: May 2023

Why are we in the Netherlands today so much richer than our grand and great-grand parents, living only 50, 100, 200 years ago? Or why are some countries richer than other? Questions like these lie at the heart of Economic History. The basis for answering these questions is consistent data on long run global development, which we collect within the Maddison Project. Our research shows that over the past 200 year, the average global income per person has increased nearly 12 times (Bolt & Van Zanden, 2020; OECD, 2021). Further, economic growth accelerated over time. During the 19th century, the average global income doubled to roughly 2200 dollars; during the twentieth century the global average income quadrupled to over 12,000 dollars. While this is impressive economic progress, if we look at different countries around the world today, it is clear that this average development has not brought everyone the same progress. Economic history research and Africa One of the regions that currently features in the lower half of the world’s income distribution is Africa. However, for long, Africa hardly featured in global economic history debates due to lacking historical data on development. In my lecture I will discuss how economic history research, based on previously unexplored archival material, has not only rewritten African history, but also provided a much better understanding of drivers of development. This has pushed Africa’s long run experience into global economic history debates and thereby provided important new impetus into theories of long run global development.
Diversidad de artrópodos asociados a traspatios con dominancia de árboles de durazno Prunus persica (Rosales: Rosaceae) en el Estado de México
Authors: Hernández-Cumplido Johnattan , Cruz-Caballero Mayte , Reyes-Hernández Laura , Castellanos-Vargas Iván
Published: May 2023

Los traspatios son relevantes para el humano ya que proveen alimento y pueden ser reservorios de biodiversidad. Sin embargo, estos agroecosistemas han sido poco estudiados debido a la enorme variación de tamaño, forma y manejo que presentan. El objetivo de este trabajo fue evaluar la abundancia y riqueza de artrópodos asociados a traspatios con dominancia de durazno Prunus persica (L.) Stokes en el centro de México, a lo largo de dos temporadas climáticas (lluvias y seca). Se muestrearon cinco traspatios dentro de una misma comunidad humana mediante trampas de caída (pitfall), las cuales fueron monitoreadas mensualmente durante 12 meses (mayo 2017–mayo 2018). Se colectaron 3,263 individuos pertenecientes a nueve órdenes identificados para 175 morfoespecies. Los órdenes más abundantes y con mayor riqueza en ambas temporadas fueron consistentemente Diptera, Coleoptera e Hymenoptera. La abundancia de individuos no presentó diferencias significativas entre traspatios ni entre temporadas. En el traspatio con densidades intermedias de árboles de duraznos, se presentó una menor diversidad, pero la riqueza de especies no fue significativamente diferente entre traspatios. La diversidad estimada en el presente estudio es más alta comparada con otros estudios en cultivos extensivos de durazno. Los traspatios son importantes para la conservación, no solo de especies apreciadas por el ser humano, sino que también funcionan como refugios de artrópodos, manteniendo abundancias parecidas incluso en épocas de estiaje como lo encontrado en este estudio. Esto sin contraponer la producción a pequeña escala de árboles frutales como lo son los duraznos criollos.
Federal government wage indexes
Authors: Cyronek Travis A. , To Theodore To
Published: May 2023

For nearly 50 years, the Employment Cost Index (ECI) has been providing the public with estimates of the change in employer labor costs. We explore the practicality of constructing federal wage indexes, in the spirit of the ECI, using Office of Personnel Management (OPM) salary data. To accomplish this task, we aggregate OPM records into occupation and industry groups. Although these salary data have a crosswalk for mapping OPM occupation codes into the Standard Occupational Classification system, no corresponding crosswalk exists for industries. A key hurdle, therefore, involves creating a crosswalk that assigns industry codes to OPM establishments. We create this crosswalk by developing an algorithm that uses Quarterly Census of Employment and Wages data and machine-learning tools to match agencies with a unique industry. With this agency-North American Industry Classification System crosswalk, we calculate annual Laspeyres, Paasche, and Fisher wage indexes for several aggregations. The resulting wage inflation rates are plausible and do not deviate substantially from the corresponding private industry and state and local wage inflation rates.
So Many Choices, How Do I Choose? Considerations for Selecting Digital Health Interventions to Support Immunization Confidence and Demand
Authors: Chaney Sarah Cunard , Mechael Patricia
Published: May 2023

Childhood vaccines are a safe, effective, and essential component of any comprehensive public health system. Successful and complete child immunization requires sensitivity and responsiveness to community needs and concerns while reducing barriers to access and providing respectful quality services. Community demand for immunization is influenced by multiple complex factors, involving attitudes, trust, and the dynamic relationship between caregivers and health workers. Digital health interventions have the potential to help reduce barriers and enhance opportunities for immunization access, uptake, and demand in low- and middle-income countries. But with limited evidence and many interventions to choose from, how do decision makers identify promising and appropriate tools? Early evidence and experiences with digital health interventions for immunization demand are presented in this viewpoint to help stakeholders make decisions, guide investment, coordinate efforts, as well as design and implement digital health interventions to support vaccine confidence and demand.
Congenital Telangiectatic Erythema: Scoping Review (Preprint)
Authors: Wojtara Magda Sara , Kang Jayne , Zaman Mohammed
Published: May 2023

BACKGROUND

Congenital telangiectatic erythema (CTE), also known as Bloom syndrome, is a rare autosomal recessive disorder characterized by below-average height, a narrow face, a red skin rash occurring on sun-exposed areas of the body, and an increased risk of cancer. CTE is one of many genodermatoses and photodermatoses associated with defects in DNA repair. CTE is caused by a mutation occurring in the BLM gene, which causes abnormal breaks in chromosomes.

OBJECTIVE

We aimed to analyze the existing literature on CTE to provide additional insight into its heredity, the spectrum of clinical presentations, and the management of this disorder. In addition, the gaps in current research and the use of artificial intelligence to streamline clinical diagnosis and the management of CTE are outlined.

METHODS

A literature search was conducted on PubMed, DOAJ, and Scopus using search terms such as “congenital telangiectatic erythema,” “bloom syndrome,” and “bloom-torre-machacek.” Due to limited current literature, studies published from January 2000 to January 2023 were considered for this review. A total of 49 sources from the literature were analyzed.

RESULTS

Through this scoping review, the researchers were able to identify several publications focusing on Bloom syndrome. Some common subject areas included the heredity of CTE, clinical presentations of CTE, and management of CTE. In addition, the literature on rare diseases shows the potential advancements in understanding and treatment with artificial intelligence. Future studies should address the causes of heterogeneity in presentation and examine potential therapeutic candidates for CTE and similarly presenting syndromes.

CONCLUSIONS

This review illuminated current advances in potential molecular targets or causative pathways in the development of CTE as well as clinical features including erythema, increased cancer risk, and growth abnormalities. Future studies should continue to explore innovations in this space, especially in regard to the use of artificial intelligence, including machine learning and deep learning, for the diagnosis and clinical management of rare diseases such as CTE.

CLINICALTRIAL
Hell’s Itch: A Unique Reaction to UV Exposure (Preprint)
Authors: Ball Katelin J , Muse Brandon W , Cook Bailey , Quinn Alyssa P , Brooks Benjamin D
Published: May 2023

UNSTRUCTURED

We present a survey-based exploration of Hell’s Itch, a severe dermatologic reaction often mistaken for sunburn, that reveals distinct symptoms including intense pain, unrelenting itching, paresthesia, and even suicidal ideation, differentiating it from a typical sunburn.
Risk Factors Associated With Burden of Disease of Psoriasis From 1990 to 2019: Epidemiological Analysis (Preprint)
Authors: Kulkarni Vishnutheertha , Liu David , Gamsarian Vahram , Grewal Tjinder , Sivesind Torunn
Published: May 2023

UNSTRUCTURED

N/A
Designing High-Fidelity Mobile Health for Depression in Indonesian Adolescents Using Design Science Research: Mixed Method Approaches (Preprint)
Authors: Shania Mila , Handayani Putu Wuri , Asih Sali
Published: May 2023

BACKGROUND

COVID-19 mitigation protocols, enacted to control the pandemic, have also been shown to have a negative impact on mental health, including the mental health of adolescents. The threat of being infected by SARS-CoV-2 and substantial changes in lifestyle, including limited social interaction due to stay-at-home orders, led to loneliness as well as depressive symptoms. However, offline psychological assistance is restricted, as psychologists are bounded by mitigation protocols. Further, not all adolescents’ guardians are open to their children attending or have the means to pay for psychological service; thus, adolescents remain untreated. Having a mobile health (mHealth) app for mental health that uses monitoring, provides social networks, and delivers psychoeducation may provide a solution, especially in countries that have limited health facilities and mental health workers.

OBJECTIVE

This study aimed to design an mHealth app to help prevent and monitor depression in adolescents. The design of this mHealth app was carried out as a high-fidelity prototype.

METHODS

We used a design science research (DSR) methodology with 3 iterations and 8 golden rule guidelines. The first iteration used interviews, and the second and third iterations used mixed method approaches. The DSR stages include the following: (1) identify the problem; (2) define the solution; (3) define the solution objective; (4) develop, demonstrate, and evaluate the solution; and (5) communicate the solution. This study involved students and medical experts.

RESULTS

The first iteration resulted in a wireframe and prototype for the next iteration. The second iteration resulted in a System Usability Scale score of 67.27, indicating a good fit. In the third iteration, the system usefulness, information quality, interface quality, and overall values were 2.416, 2.341, 2.597, and 2.261, respectively, indicating a good design. Key features of this mHealth app include a mood tracker, community, activity target, and meditation, and supporting features that complement the design include education articles and early detection features.

CONCLUSIONS

Our findings provide guidance for health facilities and to design and implement future mHealth apps to help treat adolescent depression.
Applications of the Natural Language Processing Tool ChatGPT in Clinical Practice: Comparative Study and Augmented Systematic Review (Preprint)
Authors: Schopow Nikolas , Osterhoff Georg , Baur David
Published: May 2023

BACKGROUND

This research integrates a comparative analysis of the performance of human researchers and OpenAI's ChatGPT in systematic review tasks and describes an assessment of the application of natural language processing (NLP) models in clinical practice through a review of 5 studies.

OBJECTIVE

This study aimed to evaluate the reliability between ChatGPT and human researchers in extracting key information from clinical articles, and to investigate the practical use of NLP in clinical settings as evidenced by selected studies.

METHODS

The study design comprised a systematic review of clinical articles executed independently by human researchers and ChatGPT. The level of agreement between and within raters for parameter extraction was assessed using the Fleiss and Cohen κ statistics.

RESULTS

The comparative analysis revealed a high degree of concordance between ChatGPT and human researchers for most parameters, with less agreement for study design, clinical task, and clinical implementation. The review identified 5 significant studies that demonstrated the diverse applications of NLP in clinical settings. These studies’ findings highlight the potential of NLP to improve clinical efficiency and patient outcomes in various contexts, from enhancing allergy detection and classification to improving quality metrics in psychotherapy treatments for veterans with posttraumatic stress disorder.

CONCLUSIONS

Our findings underscore the potential of NLP models, including ChatGPT, in performing systematic reviews and other clinical tasks. Despite certain limitations, NLP models present a promising avenue for enhancing health care efficiency and accuracy. Future studies must focus on broadening the range of clinical applications and exploring the ethical considerations of implementing NLP applications in health care settings.
Determinants of Migration Flows in Highly Skilled Migrants Interprovince in Indonesia
Authors: Krisnandita I Wayan
Published: May 2023

Migration and regional inequality are two interrelated concepts. Inequality between regions can lead to migration. High-skilled migration, or migration of high-quality human resources, has great potential to reduce interregional disparities by helping development in the destination area. However, in reality, the flow of high-skilled migration tends to lead to more advanced provinces, especially the capital and its surroundings. This condition causes disparities between regions to increase. This study analyzes the phenomenon of internal high-skilled migration between provinces in Indonesia at a macro level using a modified gravity model approach and is estimated using the zero-inflated negative binomial (ZINB) model. The results of this study show that the number of high-skilled populations in the provinces of origin and destination, geographical distance, average wages for workers, and the percentage of agricultural workers in the destination province, as well as the stock of migrants, influence the flow of high skilled migration between provinces in Indonesia. Increasing workers’ wages, access to transportation and information/social networks, as well as industrialization outside Java, need to be carried out to attract high-skilled migrants or keep high-skilled workers to remain in their provinces to realize equity between regions.
Migration During COVID-19 Pandemic in Industrial City: Case in Batam City, Indonesia
Authors: Saifimar Chantira , Pitoyo Agus Joko , Alfana Muhammad Arif Fahrudin
Published: May 2023

COVID-19 is a disease which has spread throughout the entire world and was announced as a pandemic as it infects individuals through air. As a result, policies regarding mobility and health protocols were implemented. Cities and regencies in Riau Islands act as the entrance gate to Indonesia from other countries due to its strategic locations thus migration became a very concerning thing, especially in Batam, a successful city in industry, commerce, and tourism. This study aims to identify the migration flow to and from Batam City to other regions in Riau Islands Province. This research used quantitative methods and data of people who switched domiciles from and to Batam in the scope of Riau Islands Province provided by the Population and Civil Registration Service of Batam City. After being analyzed descriptively, this study shows the number of migrants in and out of Batam fluctuated throughout 2019- 2021. The destinations and origins of migrants varied and show that distant regions were less demanded. This is due to the limited access and implementation of the mobility policies implemented during COVID-19. Reasons to migrate mostly are for work with a percentage around 16.5 to 22.7 percent and family with a percentage around 12 to 17.6 percent. However, around half of the migrants from 2019 to 2021 chose “Others” with no further specifications from the data provided.
Bourdieu dan Perspektif Alternatif Kajian Jurnalistik
Authors: Krisdinanto Nanang
Published: May 2023

Naskah ini merupakan literature review yangmengelaborasi pikiran Pierre Bourdieu tentang jurnalismeyang dapat digunakan sebagai perspektif alternatif dalammemahami dinamika praktik jurnalistik. Ada dua hal yangmembuat pikiran Bourdieu menarik dan penting untuk dikajidalam konteks jurnalistik. Pertama, perspektif Bourdieumasih jarang digunakan untuk memahami, mengutai,atau menginvestigasi dinamika yang terjadi dalam praktikjurnalistik. Padahal, konsep-konsep kunci seperti arena,habitus, dan modal dapat digunakan untuk menyingkapberbagai dinamika yang terjadi di dalam praktik jurnalistik.Kedua, orientasi teoritik Bourdieu mampu membukaruang untuk memahami praktik jurnalistik tanpa harusterjebak ke dalam dikotomi perspektif yang kaku di antaraperspektif ekonomi politik/organisasional/budaya danperspektif cultural studies. Konsep kunci Bourdieu dapatdigunakan untuk mengungkap kompleksitas praktikjurnalistik yang diabaikan masing-masing perspektif. Konsep kunci Bourdieu juga dapat membuat penelititerhindar dari bahaya mereduksi praktik jurnalistik menjadihanya sekadar proses makro (seperti politik, ekonomi,atau budaya yang berbasis struktur sosial objektif), atausebaliknya hanya sebatas proses mikro (yang berbasiskebebasan atau kreativitas subjek). Dengan kata lain,konsep kunci Bourdieu digunakan sebagai alat analisisyang mampu mengkoneksikan dinamika praktik jurnalistikdengan struktur politik, ekonomi, sosial, atau budaya yangmelingkupinya.
Power Relation Between Katniss Everdeen and President Snow in The Hunger Games Trilogy
Authors: Princesa Shintya , Munjid Achmad
Published: May 2023

This paper aims to find out about the dynamic of the power relation between Katniss Everdeen and President Snow from The Hunger Games trilogy, and how the power relation reflects domination and resistance. For the analysis, this paper applies Foucault's theory of power relations. The discussion concludes that the power relation between Katniss and President Snow is formed through the distribution of power that makes them subjects who can exercise power, and in the process, leads them to create a power relation where they complement each other’s power. A productive network is then formed as they work out the power relation with objectives and rationalization to exercise their power throughout the trilogy. Furthermore, the domination and resistance are reflected in the power relation through the use of those two effects of power as strategies by President Snow and Katniss respectively. Resulting in interchanging responses of domination and resistance that affect a series of events in the story.
In vitro study of the stretching time-associated force magnitude generated by NiTi and stainless-steel closed coil springs
Authors: Ongko Jennifer Xavier , Yusuf Muslim , Bahirrah Siti
Published: May 2023

Closed coil spring is an additional tool in a fixed-orthodontic treatment. NiTi is an orthodontic alloy that has shape memory and elasticity features, while stainless steel has properties of malleability, low friction between wire-bracket, as well as easy soldering and welding. Various properties of closed coil springs have been widely studied, but research on the stretching time remains unclear. This study aimed to determine the effect and differences in the stretching time for 7 days, 14 days, 21 days, and 28 days on the force magnitude of NiTi and stainless-steel (SS) closed coil spring. A 7 x 5 x 1 cm acrylic blocks with 1 cm acrylic posts were employed, and 25 mm closed coil springs were attached to the acrylic posts using modified T-sticks. The springs were immersed in an artificial saliva with pH of 6.75 for 7, 14, 21, and 28 days in an incubator at 37 °C. The container was removed from the incubator and the force was measured using a universal testing machine. Kolmogorov-Smirnoff test was carried out to analyze parametricdata, while independent T-test was used to determine the difference between each group. There was a significant effect of stretching time on the force magnitude of the SS closed coil spring in all the groups (p < 0.05). There was no significant effect of stretching time on the force of the NiTi closed coil spring on days 7, 14, and 21 (p > 0.05) but there was a significant effect on day 28 (p < 0.05). A significant effect between the ratio of the SS and NiTi closed coil spring (p < 0.05) was confirmed. Longer stretching time indicated a force loss in the SS closed-coil spring, while the NiTi spring had a more stable force which implies a formidable treatment-time for orthodontic treatment.
Antibiofilm activity of Cyanobacteria spirulina as an irrigation solution against Enterococcus faecalis
Authors: Soesilo Diana , Pangabdian Fani , Juniar Eriza
Published: May 2023

Sodium hypochlorite (NaOCl) is currently the golden standard for root canal irrigation. NaOCl at a concentration of 5.25% to 6% can eliminate E. faecalis, but this concentration can increase the risk of toxic effects. Cyanobacteria spirulina is known to produce several secondary metabolites that have antimicrobial activity against gram-positive and gram-negative bacteria. The aim of this study was to determine the antibiofilm power of Cyanobacteria spirulina against the biofilms of Enterococcus faecalis at concentrations of 60 mg/ml, 70 mg/ml, 80 mg/ml, and 90 mg/ml. This research was a true experiment with a post-test only group design. The object of the research was divided into 6 groups. Group 1 was a negative control group, group 2 was a positive control group with 5% NaOCl, group 3, 4, 5, 6 were treatment groups given Cyanobacteria spirulina solution at a concentration of 60 mg/ml, 70 mg/ml, 80 mg/ml, and 90 mg/ml, respectively. Optical density (OD) of bacteria was bound by staining and analyzed by ELISA auto reader with a wave length of 595 nm (OD 595 nm). The results of the LSD test showed that the significance between K+ and P1, P2, P3 (p< 0.005), K+ and P4 (p= 0.129), P1 and P2 (p=0.449), P3 and P4 (p=0.178). Significance of p<0.0005 showed a significant difference between the groups. The data were analyzed using the one-way ANOVA test followed by a double comparison test with the Least Significance Different (LSD) Post Hoc test method. Cyanobacteria spirulina solution at a concentration of 90 mg/ml had the greatest inhibitory effect on the biofilm formation of Enterococcus faecalis.
The relationship between bizygomatic width and mesiodistal width of six maxillary anterior teeth in a Javanese population
Authors: Indrastuti Murti , Barunawati Sri Budi , Hasudungan Dian Samuel
Published: May 2023

The selection of the mesiodistal width of maxillary anterior teeth is the key to success in prosthodontic treatment. Determining anterior teeth width when there is no existing pre-extraction record can be done through bizygomatic width measurement. The purpose of this study was to look at the relationship between bizygomatic width and mesiodistal width of six maxillary anterior teeth in the Javanese population. This study used a cross-sectional design and was conducted on 32 Javanese subjects who met the following criteria: being 18-25 years of age, having Angle class 1 malocclusion, having complete maxillary anterior permanent teeth, not using dentures, currently not undergoing any orthodontic treatment, and having no abnormalities found in the facial area. The bizygomatic width was measured with a digital caliper with an accuracy of 0.01 mm from the marked right and left bizygomatic points. The mesiodistal width of the six maxillary anterior teeth was measured using dental floss looped from the distal left canine to the right canine. Dental floss marked with a pen was stretched horizontally on paper and then measured with a digital caliper with an accuracy of 0.01 mm. The measurement was done in triplicate. Data were analyzed using Pearson’s correlation and the simple linear regression test. This study’s analysis revealed a strong and positive correlation (r = 0.538 and p < 0.05) between the bizygomatic width and mesiodistal width of the maxillary anterior teeth. The result of the simple linear regression test showed a significant result (p < 0.05). It can be concluded that there was a relationship between the bizygomatic width and the mesiodistal width of the six maxillary anterior teeth in the Javanese population. The mesiodistal width of the six maxillary anterior teeth in the Javanese population can be measured by multiplying the bizygomatic width by the multiplier factor, i.e., 0.427.
In vitro evaluation of coenzyme Q10 on primary fibroblast culture
Authors: Herawati Dahlia
Published: May 2023

Chronic inflammation in periodontitis results in continuous production of Reactive Oxygen Species (ROS), so the levels are excessive, causing destruction of the gingiva, periodontal ligament, and alveolar bone through a variety of mechanisms including DNA damage and the formation of proinflammatory cytokine. One way to prevent periodontal tissue damage caused by excessive ROS formation is by administering antioxidants. Coenzyme Q10 is a powerful antioxidant that is beneficial for inhibiting free radicals to prevent the progression of periodontal tissue destruction and accelerate healing processes. The purpose of this study was to evaluate the fibroblast proliferation of the combination of Coenzyme Q10 and vegetable glycerin compared to PerioQ. Materials used were made of original Coenzyme Q10 dissolved in glycerin that was prepared in a ratio of 2:8 and 1:9, and Perio Q as the control. Each group consisted of six samples (n = 6). Primary fibroblasts were derived from healthy gingival tissue. Observations on day-1, -3, and -5 using MTT assay at a wavelength of 550nm. Statistical analysis used a Two-Way ANOVA test followed by a Post Hoc test.  The experiment showed the absorbance values were high in all the groups, the highest value was on day 3, namely Coenzyme Q10 at a concentration of 2:8, followed by Coenzyme Q10 at a concentration of 1:9, and PerioQ. The statistical tests showed significant differences in the 3 groups (p < 0.05). It is concluded that Coenzyme Q10 in 1:9 and 2:8 concentrations were both as viable as Perio Q towards primary gingival fibroblast culture.
The concentration effect of kulim leaf (scorodocarpus borneensis) extract on Streptococcus mutans ATCC 25175 bacterial hydrophobicity and adhesion
Authors: Utami Trianna Wahyu , Hapsari Adhaninggar Ratna , Hanalda Dhe Rifdania , Nur Asikin , Yulianto Heribertus Dedy Kusuma , Purwanti Nunuk
Published: May 2023

With the ability to reduce hydrophobicity and inhibit the adhesion of S. mutans ATCC 25175 bacteria, Kulim leaf extract can be used as an alternative to chlorhexidine mouthwash in caries prevention. The objectives of this study are to determine the effect of Kulim leaf extract on hydrophobicity and adherence of the cariogenic bacteria S. mutans ATCC 25175. The test groups were divided into negative control (DMSO 2%), the treatment group (Kulim leaf extractconcentrations of 1.25%, 2.5%, 5%), and positive control (0.1% chlorhexidine). All of groups were received three replicated tests for hydrophobicity and adherence inhibition of S. mutans ATCC 25175 bacteria. The hydrophobicity test was conducted by providing 3 ml of bacterial suspension of S. mutans ATCC 25175 which had been adjusted to the McFarland 0.5 standard for each group. Furthermore, each test group was vortexed for one minute and left to stand for 15 minutes. Each treatment was tested with a wavelength spectrophotometer of 550 nm before and after the provision of 200 µl of n-hexadecane. The absorbance value on the spectrophotometer was then included in the hydrophobicity formula to determine the hydrophobicity percentage of S. mutans ATCC 25175 against n-hexadecane. To test the bacterial adhesion, the 96 wells microplate was inserted with the kulim leaf extract of each concentration,BHI-B, bacteria according to the McFarland 0.5 standard, and for the positive control and negative control. Afterwards, they were incubated at 37 °C for 24 hours before they were rinsed with distilled water, and stained with 0.1% crystal violet. Then, an optical density reading was performed using a microplate reader with a wavelength of 540 nm. The absorbance value was then included in the formula for percentage of bacterial adhesion inhibition. Post-Hoc LSD testshowed a significant difference in mean difference between the negative control group and the other treatment groups (p<0.05). In addition, it was revealed that there was no significant mean difference between treatment groups, and there was no significant difference between positive control and treatment groups of 2.5% and 5% in the hydrophobicity test. However, there was a significant difference between the positive control and the treatment group of 1.25% in the hydrophobicity test and the treatment group of 1.25%, 2.5%, and 5% in the adherence test. This study concluded that Kulim leaf extract concentration affected hydrophobicity and attachment of S. mutans ATCC 25175 with an effective concentration of 2.5%.
Tren Pemanfaatan Basis data Elektronik di Perpustakaan Universitas Gadjah Mada Dalam Mendukung Proses Pembelajaran Masa Pandemi Covid-19
Authors: Sukirno  , Surachman Arif
Published: May 2023

Pandemi Covid-19 membawa dampak yang begitu luas kepada seluruh tatanan kehidupan manusia di dunia, tidak terkecuali di dunia Pendidikan. Pola pembelajaran yang sebelumnya berbasis luring, secara tiba-tiba harus digantikan dengan pola pembelajaran secara daring. Institusi pendidikan tak terkecuali pendidikan tinggi harus dapat menyesuaikan perubahan ini dengan cepat. Transformasi digital yang sebelumnya sudah dilakukan harus dilakukan dengan lebih cepat. Perpustakaan sebagai salah satu ujung tombak penyediakan sumber daya akademik bagi sivitas akademika, juga harus mengikuti situasi yang ada. Beruntung bahwa, transformasi digital yang dilakukan perpustakaan sudah terjadi sejak jauh sebelum pandemic, dengan penyediaan sumber daya elektronik berupa e-journal, e-book, e-theses, e-databases, dan bentuk elektronik lainnya. Sumber daya elektronik tersebut disediakan dengan mempertimbangkan berbagai kebutuhan dari semua fakultas dan sekolah yang ada. Tulisan ini mencoba mendeskripsikan tren pemanfaatan basis data elektronik yang disediakan oleh Perpustakaan UGM dalam masa pandemi (tahun 2020-2021). Data yang ada, memperlihatkan bahwa terjadi peningkatan secara signifikan pemanfaatan basis data elektronik pada masa pandemi. Beberapa basisdata berbasis multi disiplin terlihat secara konsisten lebih banyak dimanfaatkan oleh sivitas akademika seperti ScienceDirect, Taylor and Francis Journal, Springer Journals, Sage Journals, dan Emeralds Journals. Basis data elektronik lintas fakultas juga terlihat lebih banyak pemanfaatannya disbanding basis data bidang ilmu tertentu. Di sisi lain, terdapat beberapa penurunan pemanfaatan basis data elektronik dari penyedia tertentu. Penelitian lebih lanjut diperlukan untuk mengevaluasi lebih dalam tren pemanfaatan basis data elektronik di Universitas Gadjah Mada.
Representasi Perpustakaan Nasional Republik Indonesia dalam Konten Akun Instagram
Authors: Tri Rahma Kusuma Wardani
Published: May 2023

Dalam perkembangan teknologi informasi, media sosial adalah salah satu produknya. Media sosial kini tidak hanya digunakan oleh perorangan untuk berkomunikasi dengan teman, namun juga digunakan oleh lembaga, termasuk Perpustakaan Nasional (Perpusnas). Media sosial Instagram yang dimiliki Perpusns adalah representasi lembaga perpustakaan sebagai garda terdepan mendukung perkembangan ilmu pengetahuan dan teknologi informasi. Tujuan dari penulisan ini adalah untuk mengetahui makna dibalik unggahan akun Instagram Perpusnas. Penulisan ini menggunakan analisis semiotika Roland Barthes dengan memaknai tanda yang terdapat dalam unggahan Instagram Perpusnas. Dari hasil analisis ditemukan bahwa representasi Perpustanas di akun Instagramnya menunjukkan bahwa Perpusnas adalah lembaga yang mengikuti perkembangan masyarakat melalui tulisan dan tagar yang dimuat, serta Perpusnas merupakan tempat kaum parlente bagi yang ingin memperkaya ilmu pengetahuannya
Fluorescent Probes Based on Metal and Aggregation-induced Luminescent Organic Molecule Complexes for Bioimaging and Sensing Applications
Authors: Liu Ke
Published: May 2023

Metal-Organic Coordination polymer (MOCPs) is an emerging class of inorganic-organic porous hybrid materials with infinite coordination polymers (CPs) or metal-organic backbones (MOFs) formed by the interaction between metal ions and organic ligands and ligand functional groups. The molecular structure of the organic ligands composing MOCPs is rich in variation, while inorganic metal ions generally have good photoelectromagnetic properties. Therefore, MOCPs have diverse structural variations, adjustable pore size, high stability and controllable synthesis, and have received wide attention in gas storage, multiphase catalysis, chemical sensing and biological applications. Fluorescence properties are one of the most widely used techniques for bioimaging and sensing detection. However, conventional luminescent groups are usually affected by aggregation-induced quenching (ACQ) effects. Aggregation-induced luminescence molecules (AIEs) based on metal-organic coordination polymers combine the advantages of organic AIEs and transition metal centers to improve photophysical properties and therapeutic effects.
Introduction to the Reform Direction of Vehicle Engineering Major
Authors: Cui Xilong
Published: May 2023

In the era of modern technology and information development, the automotive industry is expanding, and the demand for talents in the automotive industry is getting richer and richer. Faced with the continuous promotion of the “new four” in the automotive industry, universities need to make corresponding adjustments to the current problems and future trends of the industry development in the education and teaching courses of vehicle engineering, and consider how to cultivate comprehensive talents who can promote the development of the industry in the flood of the new era. Based on this, this paper focuses on the new requirements of the automotive industry for the comprehensive quality of talents, takes the needs of the industry as the guide, reconstructs the new mechanism of combining industry-university-research, carries out joint training of school and enterprise, builds a research-oriented and open engineering practice teaching system, establishes a part-time teaching team with engineering background, strengthens students’ engineering ability, innovation ability and team cooperation ability, and realizes the docking of talents cultivated by school and talents demanded by enterprise. To establish a new mode of training talents in vehicle engineering.
Research on Common Faults and Maintenance Countermeasures of Automobile Engines
Authors: Cui Xilong
Published: May 2023

With the rapid development of automobile industry, the number of automobiles in China has exceeded 290 million. The increase of car ownership has promoted the development of auto repair industry to a certain extent, but it is an indisputable fact that the overall level of China’s auto repair industry is low. In recent years, the performance of automobile engines has been rapidly developed, not only the power and horsepower have been greatly improved, but also the reliability has been greatly improved, but the engine failure is still inevitable. Based on this, several common failures of automobile engines and their solutions are analyzed in this paper for reference only.
Bradykinin receptors in GtoPdb v.2023.1
Authors: Coulson Joseph , Couture Réjean , Faussner Alexander , Gobeil Jr Fernand , Leeb-Lundberg Fredrik , Marceau Francois , Muller-Esterl Werner , Pettibone Doug , Zuraw Bruce
Published: May 2023

Bradykinin (or kinin) receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Bradykinin (kinin) Receptors [92]) are activated by the endogenous peptides bradykinin (BK), [des-Arg9]bradykinin, Lys-BK (kallidin), [des-Arg10]kallidin, [Phospho-Ser6]-Bradykinin, T-kinin (Ile-Ser-BK), [Hyp3]bradykinin and Lys-[Hyp3]-bradykinin. Variation in pharmacology and activity of B1 and B2 receptor antagonists at species orthologs has been documented. icatibant (Hoe140, Firazir) is approved in North America and Europe for the treatment of acute attacks of hereditary angioedema. Inhibition of bradykinin with icatibant in COVID-19 infection is under clinical evaluation, with trial NCT05407597 expected to complete in mid 2023.
Cannabinoid receptors in GtoPdb v.2023.1
Authors: Abood Mary , Alexander Stephen P.H. , Barth Francis , Bonner Tom I. , Bradshaw Heather , Cabral Guy , Casellas Pierre , Cravatt Ben F. , Devane William A. , Di Marzo Vincenzo , Elphick Maurice R. , Felder Christian C. , Greasley Peter , Herkenham Miles , Howlett Allyn C. , Kunos George , Mackie Ken , Mechoulam Raphael , Pertwee Roger G. , Ross Ruth A.
Published: May 2023

Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Cannabinoid Receptors [119]) are activated by endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosatetra-7,10,13,16-enoylethanolamine and 2-arachidonoylglycerol. Potency determinations of endogenous agonists at these receptors are complicated by the possibility of differential susceptibility of endogenous ligands to enzymatic conversion [5].There are currently three licenced cannabinoid medicines each of which contains a compound that can activate CB1 and CB2 receptors [111]. Two of these medicines were developed to suppress nausea and vomiting produced by chemotherapy. These are nabilone (Cesamet®), a synthetic CB1/CB2 receptor agonist, and synthetic Δ9-tetrahydrocannabinol (Marinol®; dronabinol), which can also be used as an appetite stimulant. The third medicine, Sativex®, contains mainly Δ9-tetrahydrocannabinol and cannabidiol, both extracted from cannabis, and is used to treat multiple sclerosis and cancer pain.
Adenosine receptors in GtoPdb v.2023.1
Authors: Fredholm Bertil B. , Frenguelli Bruno G. , Hills Rebecca , IJzerman Adriaan P. , Jacobson Kenneth A. , Klotz Karl-Norbert , Linden Joel , Müller Christa E. , Schwabe Ulrich , Stiles Gary L.
Published: May 2023

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [112]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [155, 316, 224, 62], agonist-bound [379, 205, 206] and G protein-bound A2A adenosine receptors [49] have been described. The structures of an antagonist-bound A1 receptor [130] and an adenosine-bound A1 receptor-Gi complex [87] have been resolved by cryo-electronmicroscopy. Another structure of an antagonist-bound A1 receptor obtained with X-ray crystallography has also been reported [58]. The structure of the A2B receptor has also been elucidated [57]. caffeine is a nonselective antagonist for adenosine receptors, while istradefylline, a selective A2A receptor antagonist, is on the market for the treatment of Parkinson's disease.
Complement peptide receptors in GtoPdb v.2023.1
Authors: Cianciulli Antonia , Coulthard Liam , Hawksworth Owen , Lee John D. , Li Xaria X. , Mitolo Vincenzo , Monk Peter , Panaro Maria A. , Woodruff Trent M.
Published: May 2023

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [113]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3a receptor, C5a receptor 1 and C5a receptor 2), causing cell recruitment and triggering cellular degranulation that contributes to local inflammation.