bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh return on equity dan debt to equity ratio terhadap stock return
Authors: Tamba Alpiner
Published: June 2022

This study aims to examine the effect of Return On Equity (ROE) and Debt to Equity Ratio (DER) on Stock Prices of Food and Beverages Sector Companies Listed on the Indonesia Stock Exchange. The data used in this research is secondary data which comes from the financial statements of companies on the Indonesia Stock Exchange. The population used in this study were all companies in the food and beverage sector listed on the IDX. This study uses purposive sampling technique with predetermined criteria. The number of samples used in this study were 7 companies. The analytical method used is multiple linear regression analysis.
The Urgent Need to Amend the Indonesian Law on Currencies to Face the Digital Age
Authors: Nefi Arman , Sardjono Agus
Published: June 2022

This research focuses on Indonesian Law No. 7 of 2011 on Currency. Over the past ten years, information technology has developed so rapidly that it has been necessary to take another look at whether this law is still relevant now and in the near future. The research uses normative legal analysis methods with a conceptual approach, analytical approach, comparative approach across multiple countries, and case studies. The rapid development has left the law behind when addressing violations of the currency law. To eliminate ambiguity and hesitation in the implementation of the use of currency, this law must be amended. It is necessary to establishclear laws on digital money or electronic money (e-money), which is currently only regulated at the level of Bank Indonesia and Bank Indonesia Circular Letter. The use of foreign currency in border markets and places of foreign tourists, money in some places due to technological advances, and about the local wisdom of a society that has a history of using certain goods as currency. Things that develop and are a reality in society should be contained in statutes to settle the law.
Development of technology for the production of metal cord with a modified brass coating
Authors: Khodosovskaya O. Yu. , Muraveiko I. A.
Published: June 2022

The results of the development of the production technology of metal cord with a modified brass coating are presented. The principal possibility of introducing cobalt into the brass coating has been determined: cobalt is recommended to be applied from a separate bath with a sulfate cobalt electrolyte, which will allow obtaining a coating of satisfactory quality over the entire surface. The use of this electrolyte required the use of inert anodes to avoid the formation of plaque on the surface, due to contamination of the solution and, as a consequence, deterioration of the quality of the resulting coating. Zn ratio/The Si in the thickness of the brass coating varies slightly (in comparison with cobalt), which indicates a low diffusion ability of cobalt in brass. Within the framework of joint development programs, prototypes of metal cord with different cobalt content in brass coating were manufactured and sent to consumer firms. The introduction of industrial technology will require a significant modernization of the coating line of thermo‑galvanic units with the installation of separate cobalt baths, with the separation of the electrolyte preparation and circulation system, the installation of separate washing baths, the separation of the current supply system, since an independent current supply system from a separate converter will be required.
Slabs for Prefabricated Road Surfaces with the Least “Keyboard” Effect
Authors: Zinevich S. I. , Кayumov A. К.
Published: June 2022

The paper studies the issue of improving the evenness of the prefabricated concrete pavement by changing the design of the slabs from which it is assembled. Irregularities of the prefabricated pavement mainly occur at the junction of the plates and are called “keyboard” effect. The reason for the unevenness is the vertical movement of the ends of the plates relative to each other when the car passes. In order to correct this situation, the authors propose to arrange transverse ribs of rectangular cross section at the ends of the plates. Such ribs will create a reliable support at the edges of the slab, which will reduce the vertical movement of its ends. To determine the effectiveness of the use of transverse ribs, a concrete slab with dimensions of  3´6 m has been examined in the paper. The transverse rib in cross section had the shape of a rectangle with sides 20´10 cm. In order to compare the test results, a concrete slab of the same dimensions, but without transverse ribs, has been studied. Deformations and stresses of the slab under load have been determined by the finite element method using the Lira software package. Calculations have shown the effectiveness of the slabs with transverse ribs mounted on its edges. The vertical displacements of the ends of the slabs with ribs are two times less than those of the slabs without ribs, and the stresses are 2.4 times less. It is obvious that the use of concrete slabs with transverse ribs at the ends will reduce the unevenness of the prefabricated coating at the points of their mating.
About One Variational Problem, Leading to а Biharmonic Equation, and about the Approximate Solution of the Main Boundary Value Problem for this Equation
Authors: Meleshko I. N. , Lasy P. G.
Published: June 2022

. Many important questions in the theory of elasticity lead to a variational problem associated with a biharmonic equation and to the corresponding boundary value problems for such an equation. The paper considers the main boundary value problem for the biharmonic equation in the unit circle. This problem leads, for example, to the study of plate deflections in the case of kinematic boundary conditions, when the displacements and their derivatives depend on the circular coordinate. The exact solution of the considered boundary value problem is known. The desired biharmonic function can be represented explicitly in the unit circle by means of the Poisson integral. An approximate solution of this problem is sometimes foundusing difference schemes. To do this, a grid with cells of small diameter is thrown onto the circle, and at each grid node all partial derivatives of the problem are replaced by their finite-difference relations.  As a result, a system of linear algebraic equations arises for unknown approximate values of the biharmonic function, from which they are uniquely found. The disadvantage of this method is that the above system is not always easy to solve. In addition, we get the solution not at any point of the circle, but only at the nodes of the grid. For real calculations and numerical analysis of solutions to applied problems, the authors have constructed its unified analytical approximate representation on the basis of the known exact solution of the boundary value problem while using logarithms. The approximate formula has a simple form and can be easily implemented numerically. Uniform error estimates make it possible to perform calculations with a given accuracy. All coefficients of the quadrature formula for the Poisson integral are non-negative, which greatly simplifies the study of the approximate solution. An analysis of the quadrature sum for stability is carried out. An example of solving a boundary value problem is considered.
Expert Component as Element of Content Strategy of Industrial Enterprise
Authors: Malaichuk V. A.
Published: June 2022

Internet marketing in the industrial market has a number of features and differs from that in the consumer market. The first is characterized by specialized and personalized approaches, as well as it must take into account the long cycle of the transaction, and the presence of a large number of decision makers. Marketers at industrial enterprises must have a range of knowledge about the market and industry trends, possess information about the organization of procurement processes and the operation of distribution channels, and be able to build a communication process with a certain type of customer. The paper presents methods for online promotion of industrial products and a study of the features of choosing of internet marketing tools for industrial enterprises. The main idea of the paper is to highlight the expert component for such enterprises as the main tool for communication with customers. To solve this problem, the internet marketing tools of an industrial enterprise has been considered and the expert component in its content strategy has been shown, approaches to the systematization of internet marketing tools have been studied. In the course of the study, general scientific methods have been used: analysis, synthesis, generalization. The result of the research is a model of product promotion in the logic of the industrial consumer's journey, which is based on the connection of the consumer's journey map with internet marketing tools.
Lake detection algorithm in point clouds of the lidar image based on three-dimensional convolutional neural network
Authors: Shanshan Xu
Published: June 2022

An algorithm for detecting lakes in a point cloud of a lidar image based on a three-dimensional convolutional neural network is proposed. The contours of the lakes were extracted from the point clouds of the lidar image and their geometric characteristics were determined using the chain code algorithm. The accuracy of the proposed algorithm for identifying lakes from clouds of laser scanning points was 96.34%. The proposed algorithm can calculate and analyze information about the shape of lakes.
Discursos da sensibilidade humana aos animais no Código Municipal de Proteção Animal de São Carlos
Authors: Alves Filho Manoel Sebastião
Published: June 2022

Este artigo pretende analisar discursos da sensibilidade humana aos animais materializados no Código Municipal de Proteção Animal de São Carlos, com o objetivo de identificar, descrever e interpretar especificidades do legislativo e diferenças de constância e intensidade em afirmações e negações de que os bichos são dotados de qualidades como sensações, emoções, consciência e linguagem. Procuramos verificar a hipótese segundo a qual sensações e emoções como dor e aflição são atribuídas aos animais com mais constância e intensidade do que habilidades cognitivas e linguísticas. Nossos pressupostos teóricos e procedimentos analíticos provêm da Análise do discurso derivada de Michel Pêcheux e de Michel Foucault, aos quais aliamos saberes da História dos animais e da História das sensibilidades. A análise demonstra o predomínio de atribuições sensitivas e emotivas aos animais.
Palavras-chave: análise do discurso; história dos animais; história das sensibilidades; código de proteção animal.
O letramento digital docente na BNCC: o uso das TDICs nas aulas de Língua Portuguesa
Authors: Acri Marcelo Cristiano , Ruiz Eliana Maria Severino Donaio
Published: June 2022

A BNCC constrói um panorama da educação, pressupondo que as escolas estão equipadas com instrumentos modernos, em funcionamento, onde são utilizadas diversas Tecnologias Digitais de Informação e Comunicação (TDICs) por professores com níveis aprofundados de letramento digital. Para comprovar essa hipótese e verificar como tais pressupostos comparecem no documento, nossa pesquisa faz um recorte, focalizando, pela via procedimental indutiva da Análise de Conteúdo, as seções referentes ao ensino de língua portuguesa na educação básica. E toma por base um quadro teórico que abarca os seguintes campos: letramento, letramento digital (letramentos-chave, níveis de desempenho) e formação de professores. O objetivo é relacionar as (in)congruências entre o que emerge no documento oficial em relação à esperada performance do professor de língua portuguesa letrado digital e o que teoricamente os estudiosos desse campo postulam para docentes com níveis aprofundados nesse tipo de letramento. Palavras-chave: letramento digital; Base Nacional Comum Curricular; formação de professores; Escrita.
Humor coletivo: tiras monotemáticas em tempos de pandemia
Authors: Ramos Paulo
Published: June 2022

É comum que as tiras cômicas dos jornais impressos e digitais abordem temas diferentes. Cada autor cria isoladamente sua história, sem o compromisso de saber previamente o que será criado nas demais séries. Mas há exceções. Houve situações pontuais em que todos os desenhistas compartilharam um mesmo assunto, planejado com antecedência entre eles. Ocorreram três casos assim na Folha de S.Paulo durante a pandemia do coronavírus. Um deles será analisado neste artigo: uma ação coletiva sobre a necessidade de uso de máscaras para proteção contra o vírus da Covid-19. A iniciativa foi veiculada em abril de 2020, um mês após o início da pandemia no Brasil, e uniu as sete séries publicadas pelo jornal. O objetivo é mostrar as singularidades de casos como esse na produção do humor, bastante ancorado no compartilhamento temático. O aporte teórico irá se apoiar em estudos textuais que analisaram estratégias humorísticas em tiras.Palavras-chave: quadrinhos; tiras cômicas; humor; pandemia.
Multimodalidade em cenas de atenção conjunta com criança cega: estudo de caso único
Authors: Fonseca Lima da Fonte Renata
Published: June 2022

Este estudo propõe discutir o funcionamento multimodal da linguagem na interação entre mãe e criança cega. A partir de estudos sobre atenção conjunta e da perspectiva linguística multimodal, analisamos dados filmados de interação entre mãe e filho cego em seu ambiente domiciliar. Para transcrição, o software Eudico Linguistic Annotator (ELAN) tem sido uma ferramenta utilizada, pois possibilita os registros dos modos semióticos no tempo exato de sua ocorrência. Os resultados deste estudo revelam iniciativas de atenção conjunta e pistas de engajamento mútuo em diversas cenas interativas cotidianas, nas quais olhares/toques, gestos táteis, movimentos corporais e produções vocais com marcações prosódicas constituíram semioses significativas na matriz multimodal da linguagem em interações de atenção conjunta entre mãe e criança cega. Palavras-chave: Multimodalidade; atenção conjunta; cegueira.
A invenção do linguista: Saussure entre os manuscritos e o Curso de Linguística Geral
Authors: Silveira Eliane
Published: June 2022

Neste artigo realizaremos um cotejamento entre o Curso de Linguística Geral (1916) e o último manuscrito descoberto: Essência dupla da linguagem (1891). O nosso objetivo é examinar alguns traços do estatuto do linguista nos dois documentos. Considerando a limitação de espaço do artigo e a amplitude dos dois documentos em questão, destacaremos os fragmentos de cada documento que contribuam explicitamente para a reflexão. A análise será realizada a partir do aparato filológico e da crítica genética, mas com vistas a uma discussão epistemológica.Neste artigo realizaremos um cotejamento entre o Curso de Linguística Geral (1916) e o último manuscrito descoberto: Essência dupla da linguagem (1891). O nosso objetivo é examinar alguns traços do estatuto do linguista nos dois documentos. Considerando a limitação de espaço do artigo e a amplitude dos dois documentos em questão, destacaremos os fragmentos de cada documento que contribuam explicitamente para a reflexão. A análise será realizada a partir do aparato filológico e da crítica genética, com vistas a uma discussão epistemológica. Palavras-chave: linguista; epistemologia; língua; Saussure.
A mudança da modalidade em perspectiva construcional: uma reanálise para “pode ser”
Authors: Souza Cibele Naidhig de
Published: June 2022

O objetivo deste trabalho é investigar mudanças da construção modal pode ser, em textos da língua portuguesa provenientes dos séculos XII a XX. Para tanto, propõe-se um exercício de análise em que se integram mapas de conectividade semântica da modalidade, entendidos como ferramentas para a descrição sincrônica e diacrônica, e uma abordagem da gramática de construções. Analisam-se diferentes propostas descritivas para o campo conceitual da modalidade e se postula que o modelo de Narrog (2012), que cruza orientação de modalidade e volitividade, é compatível com os desenvolvimentos hipotetizados para pode ser em direção à intersubjetividade (TRAUGOTT; DASHER, 2002; TRAUGOTT, 2010). Defende-se a compatibilidade entre esses encaminhamentos e a proposta de mudanças construcionais de Traugott e Trousdale (2021). Palavras-chave: mapeamento semântico; modalidade; gramática de construções; poder.
Por uma leitura de textos sincréticos em avaliações de larga escala: análise semiótica do Saeb2017
Authors: Cruz Ana Carolina de Picoli de Souza
Published: June 2022

Este artigo tece reflexões sobre concepções de leitura e de perfil de leitores na educação básica, pela análise do “Relatório Saeb 2017”. Nossa hipótese é a de que avaliações de larga escala influenciam a construção (e manutenção ou não) dessas concepções. Esse tipo de avaliação fixa uma estrutura narrativa ancorada na racionalização e centrada na competencialização, por meio do estabelecimento de uma matriz de referência para a elaboração dos testes cognitivos e de uma escala de proficiência que aponta o nível de leitura dos estudantes. Ancorados na semiótica discursiva de linha francesa, é possível tanto rever como ampliar conceitos e tratamentos dados aos textos (verbais, visuais ou sincréticos) de maneira a desenvolver as concepções citadas e contribuir com a educação básica.Palavras-chave: leitura; leitor; avaliação; textos sincréticos; semiótica discursiva.
National innovative ecosystem as a platform for the country’s social-economic development
Authors: Danilina Ya. V. , Rybachuk M. A.
Published: June 2022

Objective: to improve approaches to forming a strategy for the development of a national innovation system.

Methods: the work uses a set of methods and approaches, such as the system economic theory, the space-time analysis and

synthesis.

Results: the results of the implementation of the Strategy of Innovative Development of the Russian Federation until 2020 was analyzed, which enabled to formulate conclusions about the low efficiency of the results of its implementation. The essence of the national innovation ecosystem and the approaches to its formation were determined. The necessity of applying the ecosystem approach in the formation of the national innovation system is substantiated, recommendations on the system economic theory application in building an integrated national innovation ecosystem are presented. An approach to the organization of the national innovation system as a quadruple helix is proposed, which will ensure the connectivity of its components. The analysis of the possibilities of using digital technologies to develop innovative connections based on ecosystem principles is carried out.

Scientific novelty: it consists in the application of systemic economic theory and ecosystem principles that allow taking into account the institutional and socio-economic conditions specific to Russia for the development of the national innovation system.

Practical significance: the research results presented in the article can be used to create a strategy for the innovative development of the Russian Federation for the future, as well as for the development of the national innovation system as a whole.
Factors of success of priority investment projects in the sphere of forest exploitation in Russia: econometric analysis
Authors: Ivantsova E. D. , Pyzhev A. I.
Published: June 2022

Objective: to identify the factors that determined the success of investment projects in the field of forest development on the basis of available information about the enterprises – applicants for such projects.

Methods: regression analysis of binary choice models, logistic regression.

Results: the key constraints of the development of the Russian forest sector are identified. The review of the most relevant scientific research on the topic of investments into forest complex is carried out. Taking into account the identified problems and the analysis of the global experience in solving them, the most promising mechanism in this context was identified – that is, state support for investment projects from the priority list in the field of forest development. Based on a sample of 200 projects, a logit regression model was evaluated, which determines the impact of project parameters on the probability of their successful implementation. The hypothesis that there is a statistically significant impact on the success of investment projects was confirmed for a number of factors: the average revenue and average cost of fixed assets of the enterprise, the absence of employees in the organization, the connection of the enterprise with foreign capital and the fact that the enterprise has been unprofitable for the past three years.

Scientific novelty: for the first time, estimates were made of the contribution of the forest complex enterprises’ characteristics to the probability of successful implementation of priority investment projects in the field of forest development.

Practical signifi       : the high predictive ability of the model allows using information about the project success determinants to adjust the mechanism for providing support, which will enable to increase the share of successfully implemented projects and therefore increase the effectiveness of this measure of stimulating investment in the development of the Russian forestry industry.
Low-Power SRAM Cell and Array Structure in Aerospace Applications: Single-Event Upset Impact Analysis
Authors: Gavaskar K , Sivaranjani P , Elango S , Raja G Nirmal
Published: June 2022

One of the most critical functions of a computer is memory, as it would be impossible for it to function efficiently without it. The main memory of a computer is known as Random Access Memory (RAM). It stores operating system software, applications, and other data for the central processor unit (CPU) to perform operations swiftly and efficiently. Unfortunately, traditional static RAM (SRAMs) in aerospace applications suffers from high soft error issues such as Single Event Upset (SEU). To overcome the soft error problems, many Radiation-Hardened-Based Designs (RHBD) and Radiation-Hardened-Polar Designs (RHPD) have been developed, such as 12T We-Quatro, twelve-transistor (12T) Dice SRAM cells, and so on. However, they consume more total and static power, as well as have more delay and area. In this article, an RHPD and RHBD 12T SRAM cell is proposed to reduce power dissipation and area overhead. Compared to RHPD, the RHBD 12T SRAM cell devours less total and static power, and RHPD cells have less delay. The proposed SRAM cell is implemented in the 32 x 32 array architecture. The power consumption of a 32 x 32 SRAM array with a 12T RHBD SRAM cell is 1.33mW, which is 10.1% less than a 32 x 32 SRAM array with a 12T RHPD SRAM array is 4.23mW. Cadence virtuoso 6.1.5 at 45 nm Generic Process Design Kit (GPDK) technology file is used to simulate the comparative analysis for the SRAM cell.
Characterization of the bacterial microbiome of Amblyomma scalpturatum and Amblyomma ovale collected from Tapirus terrestris “Tapir” and Amblyomma sabanerae collected from Chelonoidis denticulate “Motelo”, Madre de Dios- Peru
Authors: Rojas-Jaimes Jesús , Lindo-Seminario David , Correa-Núñez Germán , Diringer Benoit
Published: June 2022

Background
Ticks are arthropods that can host and transmit pathogens to wild animals, domestic animals, and even humans. The microbiome in ticks can play different roles such as endosymbiont, pathogenic, and even unknowning.
Results
The bacterial microbiome of adult males Amblyomma scalpturatum and Amblyomma ovale ticks (GARS) collected from Tapirus terrestris, captured in the rural area of San Lorenzo Village and males Amblyomma sabanerae (GART) collected from Chelonoidis denticulate area of Gamita Farm in the Amazon region of Madre de Dios, Peru, was evaluated using metagenomics. The Chao1 and Shannon–Weaver analyses indicated greater bacterial richness and diversity in males ticks (GART; 613.65–2.03) compared males ticks (GARS; 102.17–0.40). Taxonomic analyses identified 478 operational taxonomic units representing 220 bacterial genera in GART and 86 operational taxonomic units representing 28 bacterial genera in GARS. Of the most prevalent genera, was Francisella (73.2%) in GART and Acinetobacter (96.8%) in GARS to be considered as the core microbiome of Amblyomma sabanerae and Amblyomma scalpturatum/ Amblyomma ovale respectively.
Conclusions
We found a high bacterial diversity in male of A. sabanerae collected from C. denticulate showed prevalence of Francisella and prevalence of Acinetobacter in male A.scalpturatum/A. ovale collected from T. terrestris .The greatest bacterial diversity and richness was found in males A. sabanerae. This is the first bacterial metagenomic study performed in A.scalpturatum/A. ovale and A. sabanerae collected from T. terrestris and C. denticulate in the Peruvian jungle.
New structure for an all-optical logic gate based on hybrid plasmonic square-shaped nanoring resonators and strips
Authors: Abdulwahed Saif H. , Wadday Ahmed Ghanim , Sattar Sinan M. Abdul
Published: June 2022

Seven all-optical logic gates based on hybrid plasmonic squared-shaped nanoring resonators and strips are proposed, designed, and numerically analyzed using Finite Element Method (FEM) with COMSOL software package. Constructive and destructive interferences between the input port(s) and the control port(s) are the main operating principles used to produce the proposed gates. The ratio of output optical power to the input power at a single port which is called the transmission threshold is selected to be 30% and the resonance wavelength is 1310 nm. All the hybrid plasmonic logic gates are performed in a single structure of 400nm x 400 nm dimensions and the performance is measured according to the values of transmission at the output port versus a wavelength range from 800 nm to 2000 nm, contrast ratio, modulation depth, and insertion loss. The transmission exceeds 100% in five gates, 146% at NOT and NAND gates, 202.3% at OR, AND, and XNOR gates. The modulation depth scores are 99.75% at the XNOR gate, 98.5% at the NOR gate, 97.67% at OR, AND, NOT, and NAND gates, and 95.29% for the XOR gate.
One-way freezing method to construct MWCNTs/BC framework in melamine foam for composite phase change materials applied in thermal management and energy conversion
Authors: Chu Yao , Wang Yibo , Min Shiru , Xue Weijia , Huang Fenglin , Cai Yibing
Published: June 2022

Latent heat storage (LHS) possesses a great energy storage density, which can reduce the pressure of imbalance between energy consumption and supply. As a commonly used medium for LHS, phase change materials (PCMs) have received growing attentions. However, some inherent defects limit further applications of PCMs. In this work, a flexible porous framework was constructed using the melamine foam (MF) as the template and the multi-walled carbon nanotubes (MWCNTs)/bacterial cellulose (BC) hybrids as the filler, then the PEG was encapsulated to fabricate the composite PCMs. Herein, we investigated the microstructure and flexibility of the three-dimensional (3D) porous matrix, and the microscopic morphology, encapsulation capacity, heat storage/release behavior, temperature regulation ability and light to thermal conversion performance of the composite PCMs were also studied. Experimental results suggested that the prepared 3D skeleton had ultra-light characteristics and outstanding resilience performance. The involvement of BC increased the specific surface area of the MF skeleton, thus its adsorption to PCMs was more stable. The thermal energy storage efficiency of composite PCMs was as high as 91.5%. Meanwhile, the composite PCMs performed sensitive thermal response behavior and could generate shape memory driven by heat. Furthermore, it showed excellent light to thermal conversion performance, with a corresponding conversion efficiency of 87.9%. This study provides a new idea for the design and development of advanced composite PCMs, which is expected to expand the applications of PCMs in heat storage, energy conversion and solar energy utilization.
Assessing Relational Coordination in a Clinical Skills Program during the COVID-19 Pandemic
Authors: Alfazari Ali S. , Ali Hebatallah A. Naim , Alessa Awad , Magzoub Mohi Eldin
Published: June 2022

Background.The global spread of the COVID-19 virus caused unprecedented interruptions in medical education. This paper evaluates Relational Coordination: communicating and relating for task integration; between the distinct roles responsible for delivering clinical teaching during the peak of the pandemic.Methodology.Using a cross-sectional design, this study assesses Relational Coordination between twelve groups within a Clinical Skills Program at a Medical School in the United Arab Emirates. It also measures three relevant well-being dimensions: namely, Job satisfaction, Work Engagement, and Burnout.Results. Overall, RC scores were moderate (3.65 out of 5.00) and were found to positively and significantly increase both job satisfaction (β = 1.1, p < 0.001) and work engagement (β = 0.8, p < 0.01). While being marginally associated with lower burnout (β=-0.5, p = 0.08). Fifty percent of participants experienced high job satisfaction, with a mean score of 5.0 out of 7.0, while 73% reported being enthusiastic about their job, with a mean score of 6.0 out of 7.0. About a third of participants (27%) reported feeling burnout.Conclusions.During times of disruption and crisis, medical education can benefit from higher levels of relational coordination. Our study shows the significant impact of relational coordination on well-being measures like job satisfaction and work engagement. To achieve favorable outcomes, and maintain academic excellence, we recommend six interventions to improve relational coordination in Clinical Skills Programs, focusing on improving communication, work processes, regular meetings, education innovations, capacity building, and the establishment of coaching and counseling programs for students and faculty.
The role of SIRT1 level and SIRT1 (rs3818292, rs3758391, rs7895833) gene polymorphisms in patients with optic neuritis and multiple sclerosis
Authors: Kubiliute Aleksandra , Gedvilaitė Greta , Vilkeviciute Alvita , Kriauciuniene Loresa , Bruzaite Akvile , Zaliuniene Dalia , Liutkeviciene Rasa
Published: June 2022

The aim: To investigate the role of SIRT1 level and SIRT1 (rs3818292, rs3758391, rs7895833) gene polymorphisms in patients with optic neuritis (ON) and multiple sclerosis (MS).Methods: We studied 79 patients with ON and 225 healthy subjects. We divided ON patients into 2 subgroups: patients with MS (n=30) and patients without MS (n=43). 6 ON patients did not have sufficient data for MS diagnosis and were excluded from subgroup analysis. The subjects' DNA was extracted from peripheral blood leukocytes and genotyped by real-time polymerase chain reaction. Results were analyzed using the program "IBM SPSS Statistics 26.0".Results: We discovered that SIRT1 rs3758391 was associated with a 2-fold increased odds of developing ON under the codominant (p=0.007), dominant (p=0.011), and over-dominant (p=0.008) models. Also, it was associated with a 3-fold increased odds ofON with MS development under the dominant (p=0.010), 2-fold increased odds under the over-dominant (p=0.032) models and a 1.2-fold increased odds of ON with MS development (p=0.015) under the additive model. We also discovered that the SIRT1 rs7895833 was significantly associated with a 2.5-fold increased odds of ON development under the codominant (p=0.001), dominant (p=0.006), and over-dominant (p<0.001) models, and a 4-fold increased odds of ON with MS development under the codominant (p<0.001), dominant (p=0.001), over-dominant (p<0.001) models and with a 2-fold increased odds of ON with MS development (p=0.013) under the additive genetic model. There was no association between SIRT1 levels and ON with/without MS development.Conclusions: We discovered that the SIRT1 rs3758391 and rs7895833 polymorphisms are associated with ON and ON with MS development.
On the effective organization of rural settlements spatial structure under the transformation and development of mountainous areas in Western China: evaluation measurement based on complex adaptability theory
Authors: Long Xiang , Yang Peifeng , Su Qingmu
Published: June 2022

The vast majority of rural settlements in Western China are located in the ecologically sensitive and diverse mountainous environment, which also experienced rapid changes in policy and institutional interventions over the past 40 years. At present, in the transitional period of "post-poverty alleviation", they have more opportunities to re-integrate themselves into the large regional development. However, there is a lack of systematic evaluation and cognition of the related functions of the spatial structure between the settlements at the regional village scale and town scale. Therefore, in this paper, the theory of complex adaptive system and its analytical NK model were introduced, and a quantitative measurement framework was constructed for the adaptability level of this kind of rural settlement spatial structure organization, so as to explore the effective path for its global optimization. Taking Xinglong Town of Chongqing in the western mountainous area as an example, it was found from the analysis that: (1) The number of villages at high comprehensive adaptation level has increased over time, which has an obvious positive correlation with the construction of transportation network, and a structural adsorption effect. (2) The spatial structure of the rural settlement system in the region has changed from weak industrial nodes - traffic single branch connection - public service decentralized coverage in 2010 to the organizational adaptation characteristics of stable industrial agglomeration - traffic expansion and extension - public service continuous coverage in 2019. (3) The spatial elements related to industry and public service in each village have an increasingly significant impact on the reconstruction and differentiation of its spatial structure. Finally, based on the changing trend of adaptability level and the correlation characteristics of regional space, in this paper, the spatial structure optimization strategy of Xinglong Town is put forward, which provides a reference basis for the coordinated development of town and village space under the township level planning in the western region.
Characterization of steel lined with multilayers of micro/nano-polymeric composites
Authors: Megahed M. , Saber D. , El-Aziz Kh. Abd
Published: June 2022

A more cost-effective method to prevent steel structures from degradation is coating. This study investigated a comparison between different configurations of three multilayers polymeric coating on both sides of steel. Epoxy filled with 1 wt%, 2wt%, and 3wt% micron or nano-sized alumina (Al2O3) particles represents the coating layers to steel on both sides. Mechanical and barrier resistance properties were conducted on the micro/nanocomposite coated specimens and compared with pure epoxy coated specimens. Barrier resistance was performed by immersing the lined steel specimens in salt solution and in citric acid medium. Adding alumina (Al2O3) particles in micron and nano size to epoxy coatings improves the barrier resistance, the tensile and hardness under dry and wet conditions as compared to pure epoxy coating. The maximum improvement of the tensile strength and barrier resistance was attained with the addition of 1wt% Al2O3 nanoparticles. Further increases in Al2O3 micro/nanoparticles cause deterioration in tensile strength and barrier resistance. Good properties were observed with stepwise graded micro/nanocomposite coatings. However, the maximum improvement of hardness under dry and wet conditions improved with the further addition of 3wt% Al2O3 nanoparticles to epoxy coatings.
Can toothpastes protect dentin against erosive tooth wear and dentin hypersensitivity at same time? An in vitro study
Authors: Lopes Raquel Marianna , Maia Mariana Beraldo , Maximiano Vinícius , Yoshida Mirian Lumi , Grandizoli Diana Roberta Pereira , Cabral Camila Cardoso , Aranha Ana Cecília Corrêa
Published: June 2022

Objectives: To evaluate different desensitizing and anti-erosive toothpastes on dentin surface loss (SL) and the number of open dentin tubules (ODT).Methods: The 10 groups (n=10) were: 1. Distilled water - negative control (N), 2. Colgate Total 12 - positive control (CT); 3. Bianco Pro Clinical (BP); 4. Bianco Advanced Repair (BA), 5. Elmex Sensitive (ES), 6. Elmex Anticaries (EA), 7. Elmex Erosion (EE); 8. Sensodyne Rapid Relief (SRR); 9. Sensodyne Repair&Protect (SRP), and 10. Colgate Pro-Relief (CP). The cycling consisting of immersion in 0.3 % citric acid (5 min) and artificial saliva (60 min), 4×/day; 5 days. Toothbrushing was performed 2x/day (45 strokes). The SL was determined using an optical profilometer. All toothpastes had their pH evaluated. The specimens were also analyzed using a scanning electron microscope (SEM) to verify the ODT, and energy dispersive spectrometry (EDS). Results: EA showed the lowest SL (p < 0.05), but not differing from EE, SRP, BPC, SRR, ES, and BA. Only the groups EA, EE and SRP was different statistically from negative and positive control . The SEM results revealed that SRP had the lowest ODT (p = 0.004). Negative control, ES, and BP showed no difference in ODT from initial condition (p > 0.005). There was a weak positive correlation between SL and ODT and SL with pH, and a negative correlation was observed between ODT and pH (all p > 0.05). Conclusion: SRP, EE, and EA decreased SL; only SRP decreased the number of ODT Clinical Significance: Some toothpastes may be more suitable for preventing only erosive tooth wear such as Elmex Erosion, Elmex Anti Caries and Sensodyne Repair and Protect, and the latter may be indicated for tubular occlusion as well. In addition, as Sensodyne Repair and Protect offers interesting results for both situations, can be indicated for patients with both conditions in the oral environment: erosive tooth wear and dentin hypersensitivity.
Adsorption performance and optimization by response surface methodology on tetracycline using Fe-doped ZIF-8 loaded with multi-walled carbon nanotubes
Authors: Li Jiacheng , Tian Tian , Jia Yannan , Xu Nannan , Yang Shujun , Zhang Chenyue , Gao Shiwei , Shen Wei , wang zheng
Published: June 2022

A metal-organic framework material, an iron-doped ZIF-8 loaded with multi-walled carbon nanotubes (FZM), was fabricated and used to adsorb tetracycline (TC) in this investigation. The adsorption impact and mechanism of TC on FZM were revealed using batch adsorption experiments and characterization analyses. The effects of Fe doping amount, pH, temperature, beginning concentration, and coexisting ions on the adsorption effect of TC were explored. It was discovered that Fe doping amount of 75 mg, pH of 6, and initial concentration of 100 mg/L produced the optimum adsorption effect. TC adsorption was also enhanced by the presence of Ca2+. The adsorption process of TC on FZM followed the pseudo-second-order (PSO) kinetic and Freundlich isotherm models, indicating that chemisorption was the dominant factor in the removal process of TC and the reaction was multilayer adsorption, with a theoretical maximum saturation capacity of 1111.11 mg/g fitted according to the Langmuir model, which was better than most other adsorbents. The procedure of TC adsorption on FZM. The adsorption process on FZM is a spontaneous, heat-absorbing process, and the adsorption capacity increases as the temperature rises. According to the findings of the FTIR study undertaken before and after adsorption, the mechanism of TC on FZM is predominantly intermolecular hydrogen bonding, surface complexation, π-π interactions, and electrostatic interactions. The projected adsorption capacity of TC was 599.78 mg/g under optimal adsorption circumstances of pH 7.1, temperature 312.5 K, and injection amount 64.43 mg/L, with a divergence of 1.73 % from the actual value, according to the response surface optimization studies. Furthermore, FZM has high reusability, and after four cycles of trials, the adsorption capacity of TC on FZM may still be greater than 370 mg/g, with a 15% loss. The cost of treating 100 mg/L of TC effluent was estimated to be around 8.35 US$/m3, indicating that FZM had excellent application possibilities for TC removal.
Development and interpretation of a clinicopathological-based model for the identification of microsatellite instability in Colorectal Cancer
Authors: Jiang Zhenxing , Cao Yinghao , Yan Lizhao , Deng Shenghe , Gu Junnan , Qin Le , Mao Fuwei , Xue Yifan , Cai Wentai , Nie Xiu , Liu Hongli , Shang Fumei , Cai Kailin , Tao Kaixiong , Wang Jiliang , Wu Ke
Published: June 2022

Background:Chemotherapy is not recommended for patients with deficient mismatch repair(dMMR)in colorectal cancer(CRC), so assessing the status of MMR is crucial for the selection of subsequent treatment. Therefore, this study aims to build predictive models to accurately and rapidly identify dMMR.Methods:A retrospective analysis based on the clinicopathological data of patients with colorectal cancer from May 2017 to December 2019 at Wuhan Union Hospital was performed. The variables were subjected to co-linearity analysis, least absolute shrinkage and selection operator (LASSO) regression and random forest (RF) feature screening. Four sets of machine learning models (i.e., extreme gradient boosting (XGBoost), support vector machine (SVM), naive bayes (NB), and random forest and a conventional logistic regression (LR) model were built for training and testing. Receiver operating characteristic (ROC) curves are plotted to evaluate the predictive performance.Findings:A total of 2279 patients were included in the analysis and were randomly divided into a training group and a test group.The final 12 clinicopathological features were incorporated into the predictive models. The Area Under the curve (AUC) values of the five predictive models were 0.8931 in XGBoost, 0.8906 in SVM, 0.8512 in NB, 0.9088 in RF and 0.8319 in LR. The results showed that the random forest exhibited the best recognition ability and outperformed the conventional logistic regression method in identifing dMMR and proficient mismatch repair (pMMR).Conclusion:Our predictive models built on routine clinicopathological data can significantly improve the diagnostic performance of dMMR and pMMR. Meanwhile, four machine learning models outperformed conventional logistic regression model.
Muscle fiber ultrastructure is associated with the immunological profile in idiopathic inflammatory myopathies.
Authors: Aguilar-Vazquez Andrea , Chavarria-Avila Efrain , Salazar-Paramo Mario , Armendariz-Borunda Juan , Toriz-González Guillermo , Rodríguez-Baeza Marcela , Sandoval-Rodriguez Ana , Villanueva-Pérez Arisbeth , Godínez-Rubí Marisol , Medina-Preciado Jose-David , Lundberg Ingrid , Lozano-Torres Yesenia , Gomez-Rios Cynthia-Alejandra , Pizano-Martinez Oscar , Martinez-Garcia Erika-Aurora , Martin-Marquez Beatriz-Teresita , Duran-Barragan Sergio , Palacios-Zárate Brenda-Lucia , Llamas-Garcia Arcelia , Gómez-Limón Livier , Mercado Monica Vazquez-Del
Published: June 2022

The diagnosis and classification of Idiopathic Inflammatory Myopathies (IIM) remain complex because of the lack of information about their pathogeny. Scanning Electron Microscopy (SEM) allows a histological analysis with better resolution, which together with the immunological profile, is useful for a better understanding of physiopathology. For immunological profile characterization, we identified the presence of autoantibodies (Ro-52, OJ, EJ, PL7, PL12, SRP, Jo-1, PMScl75, PMScl100, Ku, SAE1, NXP2, MDA5, TIF1γ, Mi-2α, Mi-2β) and quantified cytokines (IL-1β, IFN-α2, IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33) and chemokines (CCL2, CXCL8). The histological analysis was made by hematoxylin-eosin staining while the muscle fiber was characterized by SEM. We observed changes in the morphology and structure of the muscle fiber according to muscle strength and muscle enzymes. We were able to find and describe muscle fiber ultrastructure with marked irregularities, porosities, disruption in the linearity and integrity of the fascicle, more evident in patients with increased serum levels of muscle enzymes and diminished muscle strength. Even the scarce reports about the use of SEM as a tool in all clinical phenotypes of IIM, our work provides an excellent opportunity to discuss and reframe the clinical usefulness of SEM in the diagnostic approach of IIM.
Mechanical and fatigue resistance of restorations supported by welded- framework and realized using computer-aided designed prosthetic shells: in vitro pilot study
Authors: Albiero Alberto Maria , Bevilacqua Lorenzo , Pegoraro Federica , Turco Gianluca , Momic Stefano , Lenarda Roberto Di , Maglione Michele
Published: June 2022

Objective Resin coating in implants rehabilitation not always can be aesthetic, durable and comfortable for the patient mainly due to the limited dimensions of the final structure. Intraoral welding technique and computer-aided designed prosthetic shells may be a solution.This in vitro study evaluates the capacity of load and the weakest point of implant-supported provisional prosthesis using welded titanium framework.Methods Twelve samples were produced to simulate an implant supported fixed prosthetic bridge. Two implants (Ankylos; Dentsply Implant Manufacturing; Germany) were inserted inside blocks of nanoceramic material produced with a stereolithographic 3D printer. A polymethylmethacrylate (PMMA) resin shell was performed with CAD/CAM and relined on welded framework. Six samples were performed with the same procedure reducing resin thickness. The samples were subjected to fatigue test (6’500’000 cycles) using ElectroForce 3310 fatigue machine (t1); subsequently a mechanical compression test using a universal Shimadzu AGS-X 10 machine (t2). The samples were analyzed with photographic and radiographic documentation at t0, t1 and t2.Results The samples survived mechanical fatigue test without evidence of failure. The radiographic and photographic evaluation revealed the fracture of resin coating after mechanical compression test. The samples with minimal resin thickness fracture first.Conclusion Adequate assessment of the resin thickness is mandatory for the improve the longevity of this rehabilitations.Clinical Relevance CAD-CAM digital prosthetic design allows us to optimize the thicknesses and the prosthetic shapes, allowing us to obtain good degrees of resistance even in the presence of reduced prosthetic spaces