bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Horizontal Earth Pressure Acting on Box Culverts through Centrifuge Model Test
Authors: Lee Kicheol , Kim Joonyoung , Woo Sang Inn
Published: February 2022

Underground space is being utilized due to the saturation of surface ground. The box culvert, as a representative infrastructure that has moved underground, is installed to protect such fixtures as electricity and gas. Because buried box culverts are necessarily affected by soil, it is important to study the earth pressure according to soil type. Herein, the horizontal earth pressure of the buried box culvert was analyzed. Accordingly, a precisely simulated centrifuge model test was performed. Additionally, the coefficient of earth pressure was analyzed. The results had significant variability because, in the existing theory, the horizontal earth pressure acting on the side of the box culvert was only calculated using the coefficient of earth pressure and the friction angle of the soil. Therefore, a correction factor was deemed necessary for calculating the horizontal earth pressure acting on the side of the box culvert.
Making Best Use of Home-Based Rehabilitation Robots
Authors: Gallagher Justin F. , Sivan Manoj , Levesley Martin
Published: February 2022

Large-scale clinical trials have shown that rehabilitation robots are as affective as conventional therapy, but the cost-effectiveness is preventing their uptake. This study investigated whether a low-cost rehabilitation robot could be deployed in a home setting for rehabilitation of people recovering from stroke (n = 16) and whether clinical outcome measures correlated well with kinematic measures gathered by the robot. The results support the feasibility of patients independently using the robot with improvement in both clinical measures and kinematic data. We recommend using kinematic data early in an intervention to detect improvement while using a robotic device. The kinematic measures in the assessment task (hits/minute and normalised jerk) adequately pick up changes within a four-week period, thus allowing the rehabilitation regime to be adapted to suit the user’s needs. Estimating the long-term clinical benefit must be explored in future research.
A Group Theoretic Analysis of Mutual Interactions of Heat and Mass Transfer in a Thermally Slip Semi-Infinite Domain
Authors: Rehman Khalil Ur , Shatanawi Wasfi , Abodayeh Kamaleldin , Shatnawi Taqi A. M.
Published: February 2022

Group theoretic analysis is performed to get a new Lie group of transformations for non-linear differential systems constructed against mass and heat transfer in the thermally magnetized non-Newtonian fluid flow towards a heated stretched porous surface. The energy equation is used with additional effects, namely heat sink and heat source. The chemical reaction is also considered by the use of the concentration equation. The symmetry analysis helps us in numerical computations of surface quantities for (i) permeable and non-permeable surfaces, (ii) thermal slip and non-thermal slip flows, (iii) magnetized and non-magnetized flows, (iv) chemically reactive and non-reactive flows. For all these cases, the concerned emerging partial differential system is transformed into a reduced ordinary differential system and later solved numerically by using the shooting method along with the Runge-Kutta scheme. The observations are debated graphically, and numerical values are reported in tabular forms. It is noticed that the heat transfer rate increases for both the thermal slip and non-slip cases. The skin friction coefficient declines towards the Weissenberg number in the magnetized field.
Monitoring Molecular Properties of a Fluorescence Light-Up Aptamer Using Fluorescence Cross-Correlation Spectroscopy
Authors: Furuhata Yuichi , Sasaki Akira
Published: February 2022

Fluorescence light-up aptamers (FLAPs) are tools for RNA imaging, wherein the RNA of interest is appended with a FLAP sequence that can bind to a corresponding small-molecule fluorogen and enhance its fluorescence. The fluorescence properties of FLAPs have mostly been analyzed in bulk and described as the average of a large number of RNA–fluorogen complexes. In this study, we evaluated the feasibility of fluorescence correlation spectroscopy (FCS)- and fluorescence cross-correlation spectroscopy (FCCS)-based quantifications of FLAPs in a solution using Broccoli, a common FLAP, and its corresponding fluorogen, DFHBI-1T. We investigated the folding efficiency, photostability, and photophysical properties of the Broccoli–DFHBI-1T complex using their FCS/FCCS characteristics. With FCS, we observed that the fluorescence was affected by the affinity between Broccoli and DFHBI-1T and the folding (maturation) state of Broccoli RNA. Moreover, the FCCS measurement of ATTO647N-labeled Broccoli and its complex with DFHBI-1T revealed the proportion of the mature Broccoli–DFHBI-1T complex. The current FCS/FCCS-based study of Broccoli–DFHBI-1T provides a model for analyzing FLAPs and their fluorogen pairs at the single-molecule level.
An Introduction to Bacterial Biofilms and Their Proteases, and Their Roles in Host Infection and Immune Evasion
Authors: Ramírez-Larrota Juan Sebastián , Eckhard Ulrich
Published: February 2022

Bacterial biofilms represent multicellular communities embedded in a matrix of extracellular polymeric substances, conveying increased resistance against environmental stress factors but also antibiotics. They are shaped by secreted enzymes such as proteases, which can aid pathogenicity by degrading host proteins of the connective tissue or the immune system. Importantly, both secreted proteases and the capability of biofilm formation are considered key virulence factors. In this review, we focus on the basic aspects of proteolysis and protein secretion, and highlight various secreted bacterial proteases involved in biofilm establishment and dispersal, and how they aid bacteria in immune evasion by degrading immunoglobulins and components of the complement system. Thus, secreted proteases represent not only prominent antimicrobial targets but also enzymes that can be used for dedicated applications in biotechnology and biomedicine, including their use as laundry detergents, in mass spectrometry for the glycoprofiling of antibodies, and the desensitization of donor organs intended for positive crossmatch patients.
Factors Distinguishing Proximal and Distal Internal Carotid Artery Occlusions in Patients with Acute Ischemic Stroke
Authors: Ha Sang Woo , Lee Chan-Hyuk , Kim Hak Sung , Yeon Eung Koo , Lee Seung Jae , Shin Byoung-Soo , Kang Hyun Goo
Published: February 2022

Acute internal carotid artery (ICA) occlusions cause extensive brain ischemia. Accurate determination of the occlusion site facilitates rapid revascularization interventions and improves prognosis. However, proximal ICA occlusions, as determined with computed tomography (CT) angiography, often are located more distally. Therefore, we assessed clinical and imaging factors associated with the accurate determination of occlusion sites. In this observational study, we evaluated 102 patients who presented acute ischemic stroke symptoms and had a CT angiography within 6 h, showing proximal ICA occlusion. The participants were divided into two groups, depending on whether there was correspondence between digital subtraction angiography and CT angiography regarding the occlusion location. Proximal occlusions were, accordingly, categorized as “true” (correspondence) or “false” (no correspondence; distal). Demographic, clinical, and imaging features were analyzed. Multivariate regression analysis was performed to identify factors predicting the correspondence between actual ICA occlusion sites and those detected by CT angiography. The shape (Odds ratios, OR = 646.584; Confidence interval, CI = 21.703–19263.187; p < 0.001) and the length (OR = 0.696; CI = 0.535–0.904; p = 0.007) of the ICA occlusion and atrial fibrillation (OR = 0.024; CI = 0.002–0.340; p = 0.006) were significant factors. The cut-off length of ICA stump at 6.2 mm, the sensitivity was 71%, and the specificity was 70% (area under the ROC curve = 0.767).
Evaluation of a Generative Adversarial Network to Improve Image Quality and Reduce Radiation-Dose during Digital Breast Tomosynthesis
Authors: Gomi Tsutomu , Kijima Yukie , Kobayashi Takayuki , Koibuchi Yukio
Published: February 2022

In this study, we evaluated the improvement of image quality in digital breast tomosynthesis under low-radiation dose conditions of pre-reconstruction processing using conditional generative adversarial networks [cGAN (pix2pix)]. Pix2pix pre-reconstruction processing with filtered back projection (FBP) was compared with and without multiscale bilateral filtering (MSBF) during pre-reconstruction processing. Noise reduction and preserve contrast rates were compared using full width at half-maximum (FWHM), contrast-to-noise ratio (CNR), peak signal-to-noise ratio (PSNR), and structural similarity (SSIM) in the in-focus plane using a BR3D phantom at various radiation doses [reference-dose (automatic exposure control reference dose: AECrd), 50% and 75% reduction of AECrd] and phantom thicknesses (40 mm, 50 mm, and 60 mm). The overall performance of pix2pix pre-reconstruction processing was effective in terms of FWHM, PSNR, and SSIM. At ~50% radiation-dose reduction, FWHM yielded good results independently of the microcalcification size used in the BR3D phantom, and good noise reduction and preserved contrast. PSNR results showed that pix2pix pre-reconstruction processing represented the minimum in the error with reference FBP images at an approximately 50% reduction in radiation-dose. SSIM analysis indicated that pix2pix pre-reconstruction processing yielded superior similarity when compared with and without MSBF pre-reconstruction processing at ~50% radiation-dose reduction, with features most similar to the reference FBP images. Thus, pix2pix pre-reconstruction processing is promising for reducing noise with preserve contrast and radiation-dose reduction in clinical practice.
Anomalous Geomagnetic Signal Emphasized before the Mw8.2 Coastal Alaska Earthquake, Occurred on 29 July 2021
Authors: Stănică Dragoș Armand
Published: February 2022

A very strong earthquake of magnitude Mw8.2 struck the coastal zone of Alaska (USA), on 29 July 2021. This earthquake was felt around the Gulf of Alaska, on a wide offshore area belonging to USA and Canada. In order to identify an anomalous geomagnetic signal before the onset of this earthquake, we retrospectively analyze the data collected on the interval 17 June–31 July 2021, via internet, at the two geomagnetic observatories, College (CMO)—Alaska and Newport (NEW)—USA, by using the polarization parameter (BPOL) and the strain effect related to geomagnetic signal identification. Thus, for both observation sites (CMO and NEW), the daily mean distribution of the BPOL and its standard deviation (STDEV) are carried out using an FFT band-pass filtering in the ULF range (0.001–0.0083 Hz). Further on, a statistical analysis based on a standardized random variable equation is applied to emphasize the following: (a) the anomalous signature related to Mw8.2 earthquake on the both time series BPOL*(CMO) and BPOL*(NEW); (b) the differentiation of the transient local anomalies associated with Mw8.2 earthquake from the internal and external parts of the geomagnetic field, taking the NEW observatory as reference. Finally, on the BPOL*(NEW-CMO) time series, carried out on the interval 7–31 July 2021, a very clear anomaly of maximum, greater than 1.2 STDEV, was detected on 22 July, with 7 days before the onset of the Mw8.2 earthquake.
Early Critical Thinking in a Mandarin-Speaking Child: An Exploratory Case Study
Authors: Shao Xuemei , Qi Ruying , Kawaguchi Satomi , Li Hui
Published: February 2022

Critical thinking in children is a growing concern for early childhood educators; however, few studies have examined children’s critical thinking in an out-of-class context. This case study aimed toward filling this research gap by examining the critical thinking of a Mandarin-speaking child aged 5 years and 8 months in an out-of-class context. The child’s natural utterances produced in free conversation and story-readings have been audio- and video-taped twice a week over two months. The recordings have been transcribed and analyzed according to the Delphi Report and ‘level of questions’ to examine the child’s critical thinking level. Findings revealed that the child demonstrated critical thinking, and two indicators, ‘spontaneous statements’ and ‘continuous questions’, reflected children’s critical thinking level. It also found that these categories were reasonable and practical to identify young children’s critical thinking levels.
A Light-Weight CNN for Object Detection with Sparse Model and Knowledge Distillation
Authors: Guo Jing-Ming , Yang Jr-Sheng , Seshathiri Sankarasrinivasan , Wu Hung-Wei
Published: February 2022

This study details the development of a lightweight and high performance model, targeting real-time object detection. Several designed features were integrated into the proposed framework to accomplish a light weight, rapid execution, and optimal performance in object detection. Foremost, a sparse and lightweight structure was chosen as the network’s backbone, and feature fusion was performed using modified feature pyramid networks. Recent learning strategies in data augmentation, mixed precision training, and network sparsity were incorporated to substantially enhance the generalization for the lightweight model and boost the detection accuracy. Moreover, knowledge distillation was applied to tackle dropping issues, and a student–teacher learning mechanism was also integrated to ensure the best performance. The model was comprehensively tested using the MS-COCO 2017 dataset, and the experimental results clearly demonstrated that the proposed model could obtain a high detection performance in comparison to state-of-the-art methods, and required minimal computational resources, making it feasible for many real-time deployments.
Case of Study in Online Course of Computer Engineering during COVID-19 Pandemic
Authors: Lamo Paula , Perales Mikel , de-la-Fuente-Valentín Luis
Published: February 2022

Practical activities and laboratories, where the students handle hardware devices, are an important part of the curriculum in STEAM degrees. In face-to-face learning, the students go to a specific classroom where the hardware is available. However, laboratories are one of the challenges of distance education, due to the impossibility of the students attending classes at a certain place. This is especially relevant since the COVID-19 pandemic, thanks to the increase of students enrolled in distance education. Different approaches to tackle this problem have been adopted, ranging from mixed models where lectures are online but physical attendance to laboratories is required to purely virtual models where virtual worlds or augmented reality have been used to simulate the real hardware. This paper presents the case of study of a flexible laboratory for the use of Arduino in a Computer Technology course with 153 students, geographically distributed in Spain and Latin America. The goal of the case study is to study the impact of such a flexible laboratory in the course, based on four fundamental parameters: student access to the online lectures, participation in the course and marks obtained, and satisfaction surveys. The results show that students have increased their marks by 28.8% and their class attendance by 247.18%, doing more elaborate and complex work than in previous courses. Therefore, it is considered that they have satisfactorily integrated the knowledge acquired during the subject, and the projects with Arduino in Computer Technology have an impact on the flexibility and personalization of the education, motivate students and increase its educational productivity and effect on the quality of education, influencing the learning experience.
Chemical Transformation of Lignosulfonates to Lignosulfonamides with Improved Thermal Characteristics
Authors: Komisarz Karolina , Majka Tomasz M. , Pielichowski Krzysztof
Published: February 2022

Lignin is an abundantly occurring aromatic biopolymer that receives increasing attention as, e.g., a biofiller in polymer composites. Though its structure depends on the plant source, it is a valuable component showing biodegradability, antioxidant, and ultra-violet (UV) absorption properties. Lignosulfonates, a by-product of the paper and pulping industries formed as a result of the implementation of the sulfite process, have been used in the presented study as a raw material to obtain a sulfonamide derivative of lignin. Hereby, a two-step modification procedure is described. The obtained materials were investigated by means of FTIR, WAXD, SS-NMR, SEM, and TGA; the results of spectroscopic investigations confirm the formation of a sulfonamide derivative of lignin via the proposed modification method. The obtained modified lignin materials showed significantly improved thermal stability in comparison with the raw material. The internal structure of the lignosulfonate was not altered during the modification process, with only slight changes of the morphology, as confirmed by the WAXD and SEM analyses. The manufactured sulfonamide lignin derivatives show great promise in the potential application as an antibacterial filler in advanced biopolymeric composites.
Stochastic Gravitational-Wave Backgrounds: Current Detection Efforts and Future Prospects
Authors: Renzini Arianna I. , Goncharov Boris , Jenkins Alexander C. , Meyers Patrick M.
Published: February 2022

The collection of individually resolvable gravitational wave (GW) events makes up a tiny fraction of all GW signals that reach our detectors, while most lie below the confusion limit and are undetected. Similarly to voices in a crowded room, the collection of unresolved signals gives rise to a background that is well-described via stochastic variables and, hence, referred to as the stochastic GW background (SGWB). In this review, we provide an overview of stochastic GW signals and characterise them based on features of interest such as generation processes and observational properties. We then review the current detection strategies for stochastic backgrounds, offering a ready-to-use manual for stochastic GW searches in real data. In the process, we distinguish between interferometric measurements of GWs, either by ground-based or space-based laser interferometers, and timing-residuals analyses with pulsar timing arrays (PTAs). These detection methods have been applied to real data both by large GW collaborations and smaller research groups, and the most recent and instructive results are reported here. We close this review with an outlook on future observations with third generation detectors, space-based interferometers, and potential noninterferometric detection methods proposed in the literature.
Editorial of Special Issue “Tectonics and Morphology of Back-Arc Basins”
Authors: Loreto Maria Filomena
Published: February 2022

Back-arc basins are tectonic domains within subduction systems shaped mainly by extensional and transtensional tectonics or in some cases by compression, volcanism and intense hydrothermalism [...]
Impact of Biochar on Rhizosphere Bacterial Diversity Restoration Following Chloropicrin Fumigation of Planted Soil
Authors: Li Jun , Chen Yan , Qin Xiangyang , Cao Aocheng , Lu Anxiang
Published: February 2022

Chloropicrin (CP) can effectively combat soil-borne diseases but has significant side effects on nontarget microorganisms. The rhizosphere microflora play a crucial role in promoting plant growth and protecting plants from infection by soil-borne pathogens. We conducted a laboratory pot experiment to evaluate the effect of CP on the rhizosphere soil bacterial flora and the effect of biochar amendments on the reconstruction of microbial communities. Our results show that CP fumigation and biochar additions promoted the growth of cucumber plants in the later stage of the pot experiment. CP significantly inhibited the rhizobacterial diversity and changed the community composition. Biochar amendments after CP fumigation shortened the time for the rhizobacterial diversity to recover to unfumigated levels. Biochar amendments promoted the transplantation of new populations to empty microbiome niches that were caused by CP and, in particular, stimulated many beneficial microorganisms to become the predominant flora. The relative abundances of many functional taxa related to plant-disease suppressiveness and pollutant bioremediation increased, including Pseudomonas, Stenotrophomonas, Bacillus, Massilia, Acinetobacter, Delftia, Micromonospora, Cytophagaceae, and Flavisolibacter. These changes stimulated by biochar amendments would promote multifunctionality in the soil rhizosphere and benefit plant growth and disease resistance.
Coexisting with the Life of Patients with Hemodialysis: Qualitative Meta-Synthesis Study of Life of Caregivers of Patients with Hemodialysis
Authors: Kim Eun-Young , Lee Ye-Na
Published: February 2022

As the number of patients with hemodialysis (HD) continues to increase, so too does the number of people depending on caregivers. There is need to pay attention to the lives of caregivers of patients with HD, where sacrifices are forced. This study systematically reviewed and synthesized qualitative studies that explored the experiences of caregivers caring for patients with HD using the meta-synthesis method. We searched literature using four databases (i.e., PubMed, Excerpta Medica dataBASE, Cumulated Index to Nursing and Allied Health Literature, and Web of Science), and finally ten publications were selected. Four themes and nine subtopics were derived from analyzing and synthesizing the research results. The synthesized themes were: “bearing the burden of life as a caregiver,” “reconstructing life to maintain hemodialysis”, “the fading of caregiver’s own life,” and “effort to relieve the burden.” The results of this study can contribute to the development of interventional studies to improve the quality of life of HD patients. These studies provide an integrated and in-depth perspective on the experiences of caregivers who care for HD patients.
Is Medoid Suitable for Averaging GPS Trajectories?
Authors: Jimoh Biliaminu , Mariescu-Istodor Radu , Fränti Pasi
Published: February 2022

Averaging GPS trajectories is needed in applications such as clustering and automatic extraction of road segments. Calculating mean for trajectories and other time series data is non-trivial and shown to be an NP-hard problem. medoid has therefore been widely used as a practical alternative and because of its (assumed) better noise tolerance. In this paper, we study the usefulness of the medoid to solve the averaging problem with ten different trajectory-similarity/-distance measures. Our results show that the accuracy of medoid depends mainly on the sample size. Compared to other averaging methods, the performance deteriorates especially when there are only few samples from which the medoid must be selected. Another weakness is that medoid inherits properties such as the sample frequency of the arbitrarily selected sample. The choice of the trajectory distance function becomes less significant. For practical applications, other averaging methods than medoid seem a better alternative for higher accuracy.
Umbilical Endometriosis: A Systematic Literature Review and Pathogenic Theory Proposal
Authors: Dridi Dhouha , Chiaffarino Francesca , Parazzini Fabio , Donati Agnese , Buggio Laura , Brambilla Massimiliano , Croci Giorgio Alberto , Vercellini Paolo
Published: February 2022

Umbilical endometriosis represents 30–40% of abdominal wall endometriosis and around 0.5–1.0% of all cases of endometriosis. The aim of this systematic review is to revisit the epidemiology, signs, and symptoms and to formulate a pathogenic theory based on literature data. We performed a systematic literature review using the PubMed and Embase databases from 1 January 1950 to 7 February 2021, according to the PRISMA guidelines. The review was registered at PROSPERO (CRD42021239670). Studies were selected if they reported original data on umbilical endometriosis nodule defined at histopathological examination and described as the presence of endometrial glands and/or stromal cells in the connective tissue. A total of 11 studies (10 retrospective and one prospective), and 14 case series were included in the present review. Overall, 232 umbilical endometriosis cases were reported, with the number per study ranging from 1 to 96. Umbilical endometriosis was observed in 76 (20.9%; 95% CI 17.1–25.4) of the women included in studies reporting information on the total number of cases of abdominal wall endometriosis. Umbilical endometriosis was considered a primary form in 68.4% (158/231, 95% CI 62.1–74.1) of cases. A history of endometriosis and previous abdominal surgery were reported in 37.9% (25/66, 95% CI 27.2–49.9) and 31.0% (72/232, 95% CI 25.4–37.3) of cases, respectively. Pain was described in 83% of the women (137/165, 95% CI 76.6–88.0), followed by catamenial symptoms in 83.5% (142/170, 95% CI, 77.2–88.4) and bleeding in 50.9% (89/175, 95% CI 43.5–58.2). In the 148 women followed for a period ranging from three to 92.5 months, seven (4.7%, 95% CI 2.3–9.4) recurrences were observed. The results of this analysis show that umbilical endometriosis represents about 20% of all the abdominal wall endometriotic lesions and that over two thirds of cases are primary umbilical endometriosis forms. Pain and catamenial symptoms are the most common complaints that suggest the diagnosis. Primary umbilical endometriosis may originate from implantation of regurgitated endometrial cells conveyed by the clockwise peritoneal circulation up to the right hemidiaphragm and funneled toward the umbilicus by the falciform and round liver ligaments.
Keep the Balance at Home
Authors: Kopperschmidt Pascal , Maierhofer Andreas
Published: February 2022

Of the many treatment parameters in hemodialysis care that could be individualised, the dialysate sodium concentration has been identified as a prime candidate for personalisation. Newer hemodialysis machines are equipped with controllers to manage the diffusive balance of sodium between the patient and dialysate. Tailoring of intradialytic sodium transfer is possible in home hemodialysis, where individualization of therapy is particularly appropriate.
Artificial Intelligence and Cardiovascular Genetics
Authors: Krittanawong Chayakrit , Johnson Kipp W. , Choi Edward , Kaplin Scott , Venner Eric , Murugan Mullai , Wang Zhen , Glicksberg Benjamin S. , Amos Christopher I. , Schatz Michael C. , Tang W. H. Wilson
Published: February 2022

Polygenic diseases, which are genetic disorders caused by the combined action of multiple genes, pose unique and significant challenges for the diagnosis and management of affected patients. A major goal of cardiovascular medicine has been to understand how genetic variation leads to the clinical heterogeneity seen in polygenic cardiovascular diseases (CVDs). Recent advances and emerging technologies in artificial intelligence (AI), coupled with the ever-increasing availability of next generation sequencing (NGS) technologies, now provide researchers with unprecedented possibilities for dynamic and complex biological genomic analyses. Combining these technologies may lead to a deeper understanding of heterogeneous polygenic CVDs, better prognostic guidance, and, ultimately, greater personalized medicine. Advances will likely be achieved through increasingly frequent and robust genomic characterization of patients, as well the integration of genomic data with other clinical data, such as cardiac imaging, coronary angiography, and clinical biomarkers. This review discusses the current opportunities and limitations of genomics; provides a brief overview of AI; and identifies the current applications, limitations, and future directions of AI in genomics.
The “Expanded” Phases in the Low-Temperature Treated Stainless Steels: A Review
Authors: Borgioli Francesca
Published: February 2022

Low-temperature treatments have become a valuable method for improving the surface hardness of stainless steels, and thus their tribological properties, without impairing their corrosion resistance. By using treatment temperatures lower than those usually employed for nitriding or carburizing of low alloy steels or tool steels, it is possible to obtain a fairly fast (interstitial) diffusion of nitrogen and/or carbon atoms; on the contrary, the diffusion of substitutional atoms, as chromium atoms, has significantly slowed down, therefore the formation of chromium compounds is hindered, and corrosion resistance can be maintained. As a consequence, nitrogen and carbon atoms can be retained in solid solutions in an iron lattice well beyond their maximum solubility, and supersaturated solid solutions are produced. Depending on the iron lattice structure present in the stainless steel, the so-called “expanded austenite” or “S-phase”, “expanded ferrite”, and “expanded martensite” have been reported to be formed. This review summarizes the main studies on the characteristics and properties of these “expanded” phases and of the modified surface layers in which these phases form by using low-temperature treatments. A particular focus is on expanded martensite and expanded ferrite. Expanded austenite–S-phase is also discussed, with particular reference to the most recent studies.
Microstructural Evolution and the Irradiation Sensitivity of Different Phases of a High Nb-Containing TiAl Alloy under He Ions Implantation at Room- and Elevated Temperatures
Authors: Wu Zeen , Zhang Tiebang , Zhang Fan , Hu Rui , Wang Xiaoye
Published: February 2022

A high Nb-containing TiAl alloy Ti-45Al-8.5Nb-(W, B, Y) with nearly lamellar microstructure has been irradiated by 200 kV He2+ to a fluence of 1 × 1021 ions/m2 with a dose of about 1.1 dpa at 298 K and 773 K in this work. It is found that an amorphous layer formed on the surface, and no helium bubbles can be observed in the alloy after room temperature ion implantation. The surface roughness of the alloy increases significantly with the bombardment of helium ions, indicating that the ion implantation increases the surface defects. The high-temperature ion implantation leads to the phenomenon of blistering on the alloy surface, and helium bubbles are observed in both α2 and γ phases of the alloy irradiated at 773 K. The average size of the helium bubbles in the α2 (15~20 nm) is larger than that in the γ (3~5 nm) phase, while the helium bubble density is opposite. Moreover, the growth mechanism of helium bubble is also investigated. By means of nanoindentation, an obvious irradiation hardening phenomenon is measured after the room temperature ion implantation. In addition, the irradiation sensitivity of different phases is also discussed in this work. The results show that the γ phase has the highest irradiation sensitivity, α2 phase second, β phase minimum. The results of this work, especially microstructure evolution and the evaluation of phase-related irradiation sensitivity during ion implantation, can be expected to provide experimental evidence for the applications of TiAl intermetallic compounds in the nuclear industries.
Thermophysical Properties of Fe-Si and Cu-Pb Melts and Their Effects on Solidification Related Processes
Authors: Novakovic Rada , Giuranno Donatella , Lee Joonho , Mohr Markus , Delsante Simona , Borzone Gabriella , Miani Fabio , Fecht Hans-Jörg
Published: February 2022

Among thermophysical properties, the surface/interfacial tension, viscosity, and density/molar volume of liquid alloys are the key properties for the modelling of microstructural evolution during solidification. Therefore, only reliable input data can yield accurate predictions preventing the error propagation in numerical simulations of solidification related processes. To this aim, the thermophysical properties of the Fe-Si and Cu-Pb systems were analysed and the connections with the peculiarities of their mixing behaviours are highlighted. Due to experimental difficulties related to reactivity of metallic melts at high temperatures, the measured data are often unreliable or even lacking. The application of containerless processing techniques either leads to a significant improvement of the accuracy or makes the measurement possible at all. On the other side, accurate model predicted property values could be used to compensate for the missing data; otherwise, the experimental data are useful for the validation of theoretical models. The choice of models is particularly important for the surface, transport, and structural properties of liquid alloys representing the two limiting cases of mixing, i.e., ordered and phase separating alloy systems.
Drug Design, Synthesis and Biological Evaluation of Heterocyclic Molecules as Anti-Inflammatory Agents
Authors: Savjani Jignasa , Variya Bhavesh , Patel Snehal , Mulamkattil Suja , Amin Harsh , Butani Shital , Allam Ahmed , Ajarem Jamaan , Shah Harsh
Published: February 2022

Non-steroidal anti-inflammatory drugs (NSAIDs) are generally utilized for numerous inflammatory ailments. The long-term utilization of NSAIDs prompts adverse reactions such as gastrointestinal ulceration, renal dysfunction and hepatotoxicity; however, selective COX-2 inhibitors prevent these adverse events. Various scientific approaches have been employed to identify safer COX-2 inhibitors, as in any case, a large portion of particular COX-2 inhibitors have been retracted from the market because of severe cardiovascular events. This study aimed to develop and synthesize a novel series of indomethacin analogues with potential anti-inflammatory properties and fewer side effects, wherein carboxylic acid moiety was substituted using DCC/DMAP coupling. This study incorporates the docking of various indomethacin analogues to detect the binding interactions with COX-2 protein (PDB ID: 3NT1). MD simulation was performed to measure the stability and flexibility of ligand–protein interactions at the atomic level, for which the top-scoring ligand–protein complex was selected. These compounds were evaluated in vitro for COX enzymes inhibition. Likewise, selected compounds were screened in vivo for anti-inflammatory potential using the carrageenan-induced rat paw oedema method and their ulcerogenic potential. The acute toxicity of compounds was also predicted using in silico tools. Most of the compounds exhibited the potent inhibition of both COX enzymes; however, 3e and 3c showed the most potent COX-2 inhibition having IC50 0.34 µM and 1.39 µM, respectively. These compounds also demonstrated potent anti-inflammatory potential without ulcerogenic liability. The biological evaluation revealed that the compound substituted with 4-nitrophenyl was most active.
High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2′-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells
Authors: Hagimori Masayori , Hara Fumiko , Mizuyama Naoko , Fujino Takeshi , Saji Hideo , Mukai Takahiro
Published: February 2022

Zinc is an essential trace element involved in many biological activities; however, its functions are not fully understood. To elucidate the role of endogenous labile Zn2+, we developed a novel ratiometric fluorescence probe, 5-(4-methoxyphenyl)-4-(methylsulfanyl)-[2,2′-bipyridin]-6-amine (6 (rBpyZ)) based on the 6-amino-2,2′-bipyridine scaffold, which acts as both the chelating agent for Zn2+ and the fluorescent moiety. The methoxy group acted as an electron donor, enabling the intramolecular charge transfer state of 6 (rBpyZ), and a ratiometric fluorescence response consisting of a decrease at the emission wavelength of 438 nm and a corresponding increase at the emission wavelength of 465 nm was observed. The ratiometric probe 6 (rBpyZ) exhibited a nanomolar-level dissociation constant (Kd = 0.77 nM), a large Stokes shift (139 nm), and an excellent detection limit (0.10 nM) under physiological conditions. Moreover, fluorescence imaging using A549 human lung adenocarcinoma cells revealed that 6 (rBpyZ) had good cell membrane permeability and could clearly visualize endogenous labile Zn2+. These results suggest that the ratiometric fluorescence probe 6 (rBpyZ) has considerable potential as a valuable tool for understanding the role of Zn2+ in living systems.
The Difference of Volatile Compounds in Female and Male Buds of Herpetospermum pedunculosum Based on HS-SPME-GC-MS and Multivariate Statistical Analysis
Authors: Liu Zhenying , Fang Ye , Wu Cui , Hai Xian , Xu Bo , Li Zhuojun , Song Pingping , Wang Huijun , Chao Zhimao
Published: February 2022

Herpetospermum pedunculosum (Ser.) C. B. Clarke (Family Cucurbitaceae) is a dioecious plant and has been used as a traditional Tibetan medicine for the treatment of hepatobiliary diseases. The component, content, and difference in volatile compounds in the female and male buds of H. pedunculosum were explored by using headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) technology and multivariate statistical analysis. The results showed that isoamyl alcohol was the main compound in both female and male buds and its content in males was higher than that in females; 18 compounds were identified in female buds including 6 unique compounds such as (E)-4-hexenol and isoamyl acetate, and 32 compounds were identified in male buds, including 20 unique compounds such as (Z)-3-methylbutyraldehyde oxime and benzyl alcohol. (Z)-3-methylbutyraldehyde oxime and (E)-3-methylbutyraldehyde oxime were found in male buds, which only occurred in night-flowering plants. In total, 9 differential volatile compounds between female and male buds were screened out, including isoamyl alcohol, (Z)-3-methylbutanal oxime, and 1-nitropentane based on multivariate statistical analysis such as principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS-DA). This is the first time to report the volatile components of H. pedunculosum, which not only find characteristic difference between female and male buds, but also point out the correlation between volatile compounds, floral odor, and plant physiology. This study enriches the basic theory of dioecious plants and has guiding significance for the production and development of H. pedunculosum germplasm resources.
Bamboo Leaf Flavonoids Suppress Oxidative Stress-Induced Senescence of HaCaT Cells and UVB-Induced Photoaging of Mice through p38 MAPK and Autophagy Signaling
Authors: Gu Yanpei , Xue Fan , Xiao Hongrui , Chen Lihuan , Zhang Ying
Published: February 2022

With the global escalation of the aging process, the research on aging mechanisms and anti-aging strategies has become a hot spot. As the most external organ of the human body, skin can be used as an ideal organ for the study of endogenous and exogenous aging. Bamboo leaf flavonoids (BLF) possess a variety of biological effects such as antioxidant, anti-bacterial, anti-inflammatory, lipid-lowering, anti-radiation, and anti-aging. However, it is still unclear whether they can delay skin aging. This study aimed to analyze the inhibitory effect of BLF on skin aging and explore their molecular mechanisms. We found that 10–40 μg/mL BLF significantly inhibited the senescence of HaCaT cells induced by AAPH, which might be related to their antioxidant and anti-inflammatory abilities. Further mechanism studies showed that mitogen-activated protein kinase (MAPK), especially the p38 MAPK pathway, was the key to BLF to alleviate the senescence of HaCaT cells. In addition, autophagy was also involved in the anti-senescence effect of BLF. The results were also verified in UVB-induced photoaging mice. Therefore, BLF can be used as a potential therapeutic agent to intervene skin aging in vitro and in vivo.
A Survey of Basic Daily Living Assistance in Dependency Units during the Morning First Period at Nursing Homes with a Healthcare Dysfunction
Authors: Camacho-Conde José Antonio , Muñoz-Arbona David Juan
Published: February 2022

(1) Background: It is important to evaluate the attention in the basic activities of daily life in the early hours of the day to evaluate the quality of care and to be able to increase the attention of human resources in case of observing an increase in dependency. The purpose was to improve healthcare quality in nursing homes, correctly identifying the work burden and incidents of daily planning, and completing the work plan by nursing assistant staffing. (2) Methods: The sample is based on 70 elderly people. The analysis used an observational trial every workday over a six-month period. An ad hoc sheet was prepared to collect socio-demographic data on each participant, and the Barthel Index was applied to the study subjects. A daily record of three basic activities of daily living (BADL), such as dressing, bathing, and eating, was kept. (3) Results: Our results showed a significant evolution in both units, but it was in the psychogeriatric unit in which higher compliance with the schedule and higher maintained stability was reached. (4) Conclusions: The use of some BADL registers helped us address situations of imbalance in terms of user assistance and establish an interdisciplinary communication with the nursing team as a way of achieving better organization and compliance with care protocols.
Phytochemical Screening of Rosmarinus officinalis L. as a Potential Anticholinesterase and Antioxidant–Medicinal Plant for Cognitive Decline Disorders
Authors: Kamli Majid Rasool , Sharaf Abeer Abdullah M. , Sabir Jamal S. M. , Rather Irfan A.
Published: February 2022

The inhibition of acetylcholinesterase (AChE) by cholinergic agents has been promoted as a potent strategy for treating and managing cognitive decline disorders. A wide range of natural products has long been used as potential sources or formulations of cholinergic inhibitors. Therefore, this study aimed to evaluate different Rosmarinus officinalis L. (R. officinalis) extracts for their AChE inhibitory activity using galanthamine as a standard AChE inhibitor. In this study, the ethyl-acetate extract (at a concentration of 250 µg/mL) exhibited the greatest inhibitory effect against AChE with significant inhibition of 75%, comparable to the inhibitor galanthamine with an inhibition of 88%. Kinetic analysis revealed that the extracts could induce a mixed type of inhibition, as observed in the case of galanthamine, with the highest increased Km and decreased Vmax values in the ethyl acetate extract. The antioxidant potential of the three extracts tested was found to be in the order of ethyl-acetate > ethanol > aqueous, with IC50 values of 272 µg/mL, 387 µg/mL, and 534 µg/mL, respectively. Ethyl-acetate was found to have the highest total phenolic content in all extracts. Further, in silico study showed structural binding characterization of rosmarinic acid and carnosic acid with human AChE enzyme. Rosmarinic acid showed strong binding and formed two hydrogen-bonding interactions with Ser-293 and Arg-296. In light of this, the ethyl-acetate extract of the plant may provide some novel potential pharmacological leads for treating and managing cognitive disorders such as Alzheimer’s.
Identifying Personality Dimensions for Engineering Robot Personalities in Significant Quantities with Small User Groups
Authors: Luo Liangyi , Ogawa Kohei , Ishiguro Hiroshi
Published: February 2022

Future service robots mass-produced for practical applications may benefit from having personalities. To engineer robot personalities in significant quantities for practical applications, we need first to identify the personality dimensions on which personality traits can be effectively optimised by minimising the distances between engineering targets and the corresponding robots under construction, since not all personality dimensions are applicable and equally prominent. Whether optimisation is possible on a personality dimension depends on how specific users consider the personalities of a type of robot, especially whether they can provide effective feedback to guide the optimisation of certain traits on a personality dimension. The dimensions may vary from user group to user group since not all people consider a type of trait to be relevant to a type of robot, which our results corroborate. Therefore, we had proposed a test procedure as an engineering tool to identify, with the help of a user group, personality dimensions for engineering robot personalities out of a type of robot knowing its typical usage. It applies to robots that can imitate human behaviour and small user groups with at least eight people. We confirmed its effectiveness in limited-scope tests.
Adolescent Positivity and Future Orientation, Parental Psychological Control, and Young Adult Internalising Behaviours during COVID-19 in Nine Countries
Authors: Skinner Ann T. , Çiftçi Leyla , Jones Sierra , Klotz Eva , Ondrušková Tamara , Lansford Jennifer E. , Alampay Liane Peña , Al-Hassan Suha M. , Bacchini Dario , Bornstein Marc H. , Chang Lei , Deater-Deckard Kirby , Di Giunta Laura , Dodge Kenneth A. , Gurdal Sevtap , Liu Qin , Long Qian , Oburu Paul , Pastorelli Concetta , Sorbring Emma , Tapanya Sombat , Steinberg Laurence , Uribe Tirado Liliana Maria , Yotanyamaneewong Saengduean
Published: February 2022

The COVID-19 pandemic disrupted many young adults’ lives educationally, economically, and personally. This study investigated associations between COVID-19-related disruption and perception of increases in internalising symptoms among young adults and whether these associations were moderated by earlier measures of adolescent positivity and future orientation and parental psychological control. Participants included 1329 adolescents at Time 1, and 810 of those participants as young adults (M age = 20, 50.4% female) at Time 2 from 9 countries (China, Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States). Drawing from a larger longitudinal study of adolescent risk taking and young adult competence, this study controlled for earlier levels of internalising symptoms during adolescence in examining these associations. Higher levels of adolescent positivity and future orientation as well as parent psychological control during late adolescence helped protect young adults from sharper perceived increases in anxiety and depression during the first nine months of widespread pandemic lockdowns in all nine countries. Findings are discussed in terms of how families in the 21st century can foster greater resilience during and after adolescence when faced with community-wide stressors, and the results provide new information about how psychological control may play a protective role during times of significant community-wide threats to personal health and welfare.