bluuebunny/crossref_metadata_2025 huggingface dataset:
Are corporate affiliations conducive to nascent entrepreneurship?
Authors: Hopp Christian , Pruschak Gernot , Krebs Michel
Published: July 2024

Founding an entrepreneurial venture does not comprise a dichotomous choice between market entry and non-entry; instead, a wide variety of entrepreneurial strategies are available to the nascent entrepreneur. Using data from the second Panel Study of Entrepreneurial Dynamics (PSED II), a representative sample of nascent entrepreneurial activity in the United States, this study documents that nascent entrepreneurs generally choose between founding an independent new venture and following a type of corporate-affiliated entrepreneurial strategy (CAES), such as a franchise, spin-off, or similar approach. The success of this decision is contingent upon entrepreneurs’ stock of human capital. Relevant industry experiences tend to reduce the likelihood of an entrepreneur employing a CAES, while managerial experience and previous start-up experience increases the probability. Overall, those nascent entrepreneurs who follow a CAES are more likely to achieve a first positive cash-flow; this highlights the benefits of corporate affiliations in the field of new venture founding.
Graphene-Based Field-Effect Photodetector with HgCdTe Absorber
Authors: Sheremet Volodymyr , Rabbe Md Fazle , Jacobs Randy N. , Avrutin Vitaliy , Ӧzgür Ümit , Dhar Nibir K.
Published: July 2024

A field-effect photodetector structure composed of an Al2O3-encapsulated bilayer graphene conductive channel attached to an Al2O3 dielectric layer deposited on a HgCdTe absorbing layer on CdTe/Si <211> was studied. Ti/Au ohmic contacts to the graphene layer were used as drain and source electrodes and back-gate voltage was applied to the Si substrate. It was demonstrated that 80% and 10% modulation of the graphene channel conductivity can be achieved under blue (50 W/cm2) and infrared (IR) (0.02 W/cm2) illumination, respectively, at a gate voltage of 7 V. Detector responsivity was measured as 406 A/W and 1.83 A/W under IR lamp and 405-nm laser irradiation, respectively, with corresponding gain values of 340 and 5.6. The detectivity of the 4 × 4 photodetector arrays was on the order of 1010 Jones for the mid-wave infrared wavelength range (3–5 μm).
A comprehensive systematic review of health-related quality of life measures in short stature paediatric patients
Authors: Adedeji Adekunle , Witt Stefanie , Innig Florian , Quitmann Julia
Published: July 2024

This systematic review investigates Patient-reported Outcome Measures (PROMs) and Observed Reported Outcome Measures (ObsROMs) pertinent to assessing Health-Related Quality of Life (HRQoL) in short-stature paediatric patients, focusing on Achondroplasia (ACH), Growth Hormone Deficiency (GHD), Isolated Growth Hormone Deficiency (IGHD), and Small-for-Gestational-Age (SGA) diagnoses. Utilising rigorous selection criteria, 53 studies published from 1998 to 2023 were analysed, revealing a predominance of European-based research. Notably, the review elucidated the utilisation of disease-specific and generic HRQoL measures, showcasing the multifaceted nature of short-stature conditions and their impact across physical, emotional, and social domains. The Quality of Life in Short Stature Youth (QoLISSY), Paediatric Quality of Life Inventory (PedsQL), and KIDSCREEN emerged as frequently employed instruments, offering nuanced insights into HRQoL perceptions across diverse age demographics. Additionally, the review highlighted the adaptation of adult HRQoL measures for adolescent populations, signalling a need for age-appropriate assessment tools. Furthermore, integrating PROMs and ObsROMs in HRQoL assessment underscored a comprehensive approach, considering both subjective patient perspectives and observed outcomes. Future research directions encompass comprehensive search strategies, longitudinal studies with diverse populations, and the development of age-appropriate HRQoL assessment tools. In conclusion, this review emphasises the importance of comprehensive HRQoL assessment to address the diverse needs of short-stature paediatric patients effectively.
Mode division multiplexing reconstructive spectrometer with an all-fiber photonics lantern
Authors: Liang Junrui , Ye Jun , Ma Xiaoya , Lu Yao , Li Jun , Xu Jiangming , Chen Zilun , Leng Jinyong , Jiang Zongfu , Zhou Pu
Published: July 2024

This study presents a high-accuracy, all-fiber mode division multiplexing (MDM) reconstructive spectrometer (RS). The MDM was achieved by utilizing a custom-designed 3 × 1 mode-selective photonics lantern to launch distinct spatial modes into the multimode fiber (MMF). This facilitated the information transmission by increasing light scattering processes, thereby encoding the optical spectra more comprehensively into speckle patterns. Spectral resolution of 2 pm and the recovery of 2000 spectral channels were accomplished. Compared to methods employing single-mode excitation and two-mode excitation, the three-mode excitation method reduced the recovered error by 88% and 50% respectively. A resolution enhancement approach based on alternating mode modulation was proposed, reaching the MMF limit for the 3 dB bandwidth of the spectral correlation function. The proof-of-concept study can be further extended to encompass diverse programmable mode excitations. It is not only succinct and highly efficient but also well-suited for a variety of high-accuracy, high-resolution spectral measurement scenarios.

Graphical Abstract
Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers
Authors: Hosonaga Mari , Habano Eri , Arakawa Hiromi , Kaneko Keika , Nakajima Takeshi , Hayashi Naomi , Fukada Ippei , Nakamura Akira , Haruyama Yurie , Maeda Tetsuyo , Inari Hitoshi , Kobayashi Takayuki , Nakashima Eri , Ueno Takayuki , Takano Toshimi , Takahashi Shunji , Ohno Shinji , Ueki Arisa
Published: July 2024

Background

Li-Fraumeni syndrome (LFS), a hereditary condition attributed to TP53 pathogenic variants,(PV), is associated with high risks for various malignant tumors, including breast cancer. Notably, individuals harboring TP53 PVs are more likely (67–83%) to develop HER2 + breast cancer than noncarriers (16–25%). In this retrospective study, we evaluated the associations between TP53 variants and breast cancer phenotype.

Methods

We conducted a retrospective review of the medical records of patients with LFS treated at a single institution and reviewed the literature on TP53 functions and the mechanisms underlying HER2 + breast cancer development in LFS.

Results

We analyzed data for 10 patients with LFS from 8 families. The median age at the onset of the first tumor was 35.5 years. Only case 2 met the classic criteria; this patient harbored a nonsense variant, whereas the other patients carried missense variants. We observed that 9 of 10 patients developed breast cancer. Immunohistochemical analyses revealed that 40% of breast cancers in patients with LFS were HR − /HER2 + . The median age at the onset of breast cancer was slightly younger in HR − /HER2 + tumors than in HR + /HER2 −  tumors (31 years and 35.5 years, respectively).

Conclusions

The occurrence of HER2 + breast cancer subtype was 40% in our LFS case series, which is greater than that in the general population (16–25%). Some TP53 PVs may facilitate HER2-derived oncogenesis in breast cancer. However, further studies with larger sample sizes are warranted to clarify the oncogenic mechanisms underlying each subtype of breast cancer in TP53 PV carriers.
Development of a nomogram to predict recurrence scores obtained using Oncotype DX in Japanese patients with breast cancer
Authors: Shibata Akio , Tamura Nobuko , Kinowaki Keiichi , Nishikawa Aya , Tanaka Kiyo , Kobayashi Yoko , Ogura Takuya , Tanabe Yuko , Kawabata Hidetaka
Published: July 2024

Background

Chemotherapy is crucial for hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, and its survival benefits may outweigh adverse events. Oncotype DX (ODX) assesses this balance; however, it is expensive. Using nomograms to identify cases requiring ODX may be economically beneficial. We aimed to identify clinicopathological variables that correlated with the recurrence score (RS) and develop a nomogram that predicted the RS.

Methods

We included 457 patients with estrogen receptor-positive, HER2-negative breast cancer with metastases in fewer than four axillary lymph nodes who underwent surgery and ODX at our hospital between 2007 and 2023. We developed nomograms and internally validated them in 310 patients who underwent surgery between 2007 and 2021 and validated the model’s performance in 147 patients who underwent surgery between 2022 and 2023.

Results

Logistic regression analysis revealed that progesterone receptor (PgR) level, histological grade (HG), and Ki67 index independently predicted the RS. A nomogram was developed using these variables to predict the RS (area under the curve [AUC], 0.870; 95% confidence interval [CI], 0.82–0.92). The nomogram was applied to the model validation group (AUC, 0.877; 95% CI, 0.80–0.95). When the sensitivity of the nomogram was 90%, the model was able to identify 52.3% low-RS and 41.2% high-RS cases not requiring ODX.

Conclusions

This was the first nomogram model developed based on data from a cohort of Japanese women. It may help determine the indications for ODX and the use of nomogram to identify cases requiring ODX may be economically beneficial.
Physiopathologische, klinische und therapeutische Aspekte des Morbus Darier
Authors: Ahn Soo Bin , Bernard Pauline , Blanchard Mael , Morren Marie-Anne , Ettinger Monika , Hötzenecker Wolfram , Guenova Emmanuella
Published: July 2024

Der Morbus Darier (Dyskeratosis follikularis) ist eine seltene Genodermatose mit autosomal-dominanter Vererbung. Sie manifestiert sich typischerweise während der Pubertät durch braun-gelbliche, schuppige, krustig belegte Papeln in den Hautfalten und seborrhoischen Bereichen, begleitet von Nagelveränderungen und einer Beteiligung der Schleimhäute. Die Krankheit äußert sich durch schubartige Verläufe, die durch UV-Strahlung, Hitze, Reibung oder Infektionen ausgelöst werden können. Betroffene Patienten haben ein erhöhtes Risiko für Typ-1-Diabetes, Herzinsuffizienz und neuropsychiatrische Störungen. Für die kurzfristige Behandlung kommen Antibiotika/Virostatika, topische Kortikosteroide und/oder Retinoide zur Anwendung. Die langfristige Behandlung umfasst eine Systemtherapie mit Retinoiden und die Vermeidung von potenziellen Auslösefaktoren. Da es keine standardisierte Langzeittherapie gibt, werden in der Literatur zahlreiche lokale und systemische Behandlungen sowie physikalische und chirurgische Maßnahmen beschrieben.
The Effect of Social Transfers on Income Inequality and Poverty in Türkiye
Authors: Selim Raziye , Küçükçifçi Suat
Published: July 2024

This paper examines the effects of social transfers on inequality and poverty in Türkiye. We use Income and Living Conditions Survey that is conducted by TurkStat each year from 2006 to 2018. The social transfers include in cash and in-kind transfers from government to households. The standard budget incidence approach is used in the analysis. The redistribution impact of social transfers is measured using Gini coefficient and Suits coefficient and relative poverty rate. The equivalence scale adjustments are used for inequality and poverty estimations, and it is accepted as relative poverty approach. Pension income is the main factor that influences on reducing inequality and poverty. The inequality-reducing effect of pension income increased over time from 2005 to 2017. We also apply logistic regression analysis for 2018 SILC Survey. According to the logistic regression analysis, social transfers have the effect of reducing the probability of being poor in Türkiye.
Micro Knowledge as a Driver for Systemic Emergencies Management: The Case of Xylella in Italy
Authors: Latino Maria Elena , Menegoli Marta , Signore Fulvio , Corallo Angelo , De Devitiis Biagia , Viscecchia Rosaria
Published: July 2024

During emergency production systems, supply chain stakeholders’ interactions, media activities, government actions, community behaviors are stressed bringing, all, to a high-risk perception about safety. For agri-food products, it became in a variation of consumers’ purchasing behaviors, guided by uncertainty and influenced by trust. The extant knowledge about consumers’ willingness to buy for agri-food products in emergency condition does not provide evidences during a phytosanitary warning. The proposed study, considering the Xylella fastidiosa phytosanitary emergency as case study, aims to fulfill this gap analyzing the possible variations of consumers’ perception and willingness to buy of Apulian olive oil in the era of Xylella emergence by adopting a multi-perspective and systemic approach. For achieving this scope, the study follows a Process-Person-Context-Time perspective for conceiving a systemic psychological model based on the Bronfenbrenner ecological model. Seven hypotheses were tested through Structural Equation Modeling thanks to a survey in a representative sample of 779 Italian consumers. Results showed that Italian consumer’s willingness to buy the post-Xylella olive oil can fluctuate due to the hypothesized system vulnerability: family, friends, and colleague such as trust in farmers and the credibility of Italian food market are impactful; trust in processors, transporters, and government and media is not. The findings, from theoretical and sectorial perspectives, provide new knowledge on the topic, empirical evidences, and a multi-systemic model able to analyze consumers’ behaviors, understand and stimulate the search for new (or more appropriate) marketing and communication strategies to face Xylella serious economic shortages, and to act a requalification of territory at all.
Navigating causal reasoning in sustainability science
Authors: Schlüter Maja , Hertz Tilman , Mancilla García María , Banitz Thomas , Grimm Volker , Johansson Lars-Göran , Lindkvist Emilie , Martínez-Peña Rodrigo , Radosavljevic Sonja , Wennberg Karl , Ylikoski Petri
Published: July 2024

When reasoning about causes of sustainability problems and possible solutions, sustainability scientists rely on disciplinary-based understanding of cause–effect relations. These disciplinary assumptions enable and constrain how causal knowledge is generated, yet they are rarely made explicit. In a multidisciplinary field like sustainability science, lack of understanding differences in causal reasoning impedes our ability to address complex sustainability problems. To support navigating the diversity of causal reasoning, we articulate when and how during a research process researchers engage in causal reasoning and discuss four common ideas about causation that direct it. This articulation provides guidance for researchers to make their own assumptions and choices transparent and to interpret other researchers’ approaches. Understanding how causal claims are made and justified enables sustainability researchers to evaluate the diversity of causal claims, to build collaborations across disciplines, and to assess whether proposed solutions are suitable for a given problem.
Outcomes and Conclusions from the 2022 AM Bench Measurements, Challenge Problems, Modeling Submissions, and Conference
Authors: Levine Lyle , Lane Brandon , Becker Chandler , Belak James , Carson Robert , Deisenroth David , Glaessgen Edward , Gnaupel-Herold Thomas , Gorelik Michael , Greene Gretchen , Habib Saadi , Higgins Callie , Hill Michael , Hrabe Nik , Killgore Jason , Kim Jai Won , Lemson Gerard , Migler Kalman , Moylan Shawn , Pagan Darren , Phan Thien , Praniewicz Maxwell , Rowenhorst David , Schwalbach Edwin , Seppala Jonathan , Simonds Brian , Stoudt Mark , Weaver Jordan , Yeung Ho , Zhang Fan
Published: July 2024

The Additive Manufacturing Benchmark Test Series (AM Bench) provides rigorous measurement data for validating additive manufacturing (AM) simulations for a broad range of AM technologies and material systems. AM Bench includes extensive in situ and ex situ measurements, simulation challenges for the AM modeling community, and a corresponding conference series. In 2022, the second round of AM Bench measurements, challenge problems, and conference were completed, focusing primarily upon laser powder bed fusion (LPBF) processing of metals, and both material extrusion processing and vat photopolymerization of polymers. In all, more than 100 people from 10 National Institute of Standards and Technology (NIST) divisions and 21 additional organizations were directly involved in the AM Bench 2022 measurements, data management, and conference organization. The international AM community submitted 138 sets of blind modeling simulations for comparison with the in situ and ex situ measurements, up from 46 submissions for the first round of AM Bench in 2018. Analysis of these submissions provides valuable insight into current AM modeling capabilities. The AM Bench data are permanently archived and freely accessible online. The AM Bench conference also hosted an embedded workshop on qualification and certification of AM materials and components.
Impact of lower-respiratory tract infections on healthcare utilization and mortality in older adults: a Swedish population-based cohort study
Authors: Abbadi Ahmad , Gentili Susanna , Tsoumani Eleana , Brandtmüller Agnes , Hendel Merle K. , Salomonsson Stina , Calderón-Larrañaga Amaia , Vetrano Davide L.
Published: July 2024

Background

Lower respiratory tract infections (LRTIs) have an immediate significant impact on morbidity and mortality among older adults. However, the impact following the infectious period of LRTI remains understudied. We aimed to assess the short- to long-term impact of LRTIs on hospitalization, mortality, and healthcare utilization in older adults.

Methods

Data from the Swedish National Study of Aging and Care in Kungsholmen (SNAC-K) was analyzed, with data from 2001 to 2019 for mortality and 2001–2016 for healthcare utilization. LRTI-exposed participants were identified and matched with LRTI-nonexposed based on sociodemographics, lifestyle factors, and functional and clinical characteristics. Statistical models evaluated post-LRTI hospitalization risk, days of inpatient hospital admissions, healthcare visits, and mortality.

Results

567 LRTIs-exposed participants during the study period and were matched with 1.701 unexposed individuals. LRTI-exposed individuals exhibited increased risk of hospitalization at 1-year (HR 2.14, CI 1.74, 2.63), 3-years (HR 1.74, CI 1.46, 2.07), and 5-years (HR 1.59, CI 1.33, 1.89). They also experienced longer post-LRTI hospital stays (IRR 1.40, CI 1.18, 1.66), more healthcare visits (IRR 1.47, CI 1.26, 1.71), specialist-care visits (IRR 1.46, CI 1.24, 1.73), and hospital admissions (IRR 1.57, CI 1.34, 1.83) compared to nonexposed participants over 16-years of potential follow-up. Additionally, the 19-year risk of mortality was higher among LRTI-exposed participants (HR 1.45, CI 1.24, 1.70). Men exhibited stronger associations with these risks compared to women.

Conclusions

LRTIs pose both short- and long-term risks for older adults, including increased risks of mortality, hospitalization, and healthcare visits that transpire beyond the acute infection period, although these effects diminish over time. Men exhibit higher risks across these outcomes compared to women. Given the potential preventability of LRTIs, further public health measures to mitigate infection risk are warranted.
Das wahre Ich. Sexualität und Imperativ der Identität
Authors: Blattner Paul
Published: July 2024

Dieser Artikel beleuchtet die Verflechtung von der Frage nach der Sexualität und der Frage nach dem wahren Selbst. Durch die eigene Sexualität entdeckt und offenbart sich das Individuum vor sich selbst und anderen. Im Anschluss an die Werke von Michel Foucault zeigt sich, dass diese Befragung der eigenen Sexualität nicht nur ein epistemisches Unterfangen ist. Sie ist vielmehr eingebettet in eine größere Struktur von Macht und Wissen. Im Zentrum der Sexualität steht ein Imperativ der Identität, der vom Subjekt verlangt, sich innerhalb der Grenzen geltender Diskurse zu identifizieren und sich an bestehende Normen, die von den herrschenden Machtstrukturen produziert werden, zu orientieren und ihnen zu entsprechen. Abschließend werden zwei Pfade des Widerstands gegen diesen Imperativ der Identität beschrieben. Der eine betont die Möglichkeit, die Grenzen der Diskurse zu überschreiten, indem neue Wege gefunden werden, über sich selbst zu sprechen. Der andere eröffnet eine andere Perspektive auf die Sexualität, welche es uns ermöglicht, neue Beziehungen zu uns selbst und zu anderen zu gestalten.
Building a Better Wall: Assessing Children’s Design Technology Learning in Nature-Based Early Childhood Education
Authors: Speldewinde Christopher , Campbell Coral
Published: July 2024

The teaching and learning of design technology that occurs in nature-based early childhood education and care (ECEC) contexts such as nature kindergartens remains under-theorised. There is a growing body of scholarship that describes how teaching and learning occurs in these contexts as well as highlighting the benefits for young children learning in the natural environment. Recently, in the perspective of the Australian ECEC sector, how students experience design technology in nature-based contexts (bush kinders, an adaption of the European forest school approach to ECEC) was reported on. Despite design technology being accounted for in bush kinders as part of play-based learning of STEM, assessment of how this learning is supporting student’s comprehension of design technology remains an area for further attention. Often, educators rely solely on observations and anecdotal note taking for assessment which points to a need to support teachers with more rigorous assessment models. This paper adapts an assessment model for science learning and reconsiders it in terms of design technology teaching and learning. The paper’s aim is to support educators to develop children’s deeper understandings of design technology and make learning meaningful in nature-based education settings. Using vignettes, the children’s learning of design technology available in natural surroundings is analysed. This paper proposes that bush kinders are a valuable context for teaching and learning as they allow educators to develop skills to assess children’s design technology knowledge. The analysis of the data and its consideration against one play-based learning assessment model is also valuable in generating a broader narrative that deepens insights into the teaching and learning experience of design technology education in early childhood nature-based contexts.
A comprehensive analysis and comparison of lipid metabolism and inflammatory indices in patients with benign prostatic hyperplasia and prostate cancer
Authors: Xu Lei , Xu Yi , Chen Shouzhen , Shi Benkang
Published: July 2024

Aim

To investigate the role of metabolic indices in benign prostatic hyperplasia (BPH) and prostate cancer (PCa).

Methods

After exclusion of those with diabetes mellitus and incomplete characteristics, 552 PCa and 80 BPH patients who were diagnosed at Shandong University Affiliated Qilu Hospital between 2013 and 2022 were enrolled; and PCa patients were first compared to those with BPH in clinical characteristics. Then, we divided the patients into several groups according to the degree of risk and compared the variations in metabolic indices among the groups.

Results

Compared to those with BPH, patients with prostate cancer were significantly shorter (167.19±5.68 cm vs. 170.89±5.35 cm, p<0.001) and had greater BMI (25.13±3.06 kg/m2 vs. 24.25±3.08 kg/m2, p=0.019) and higher prealbumin (24.59±4.85 mg/dl vs. 23.21±4.76 mg/dl, p=0.017), TC (181.53±91.90 mg/dl vs. 167.71±30.20 mg/dl, p= 0.008), LDL (107.09±29.42 mg/dl vs. 100.22±25.01 mg/dl, p= 0.027), TG (120.74±135.60 mg/dl vs. 102.27±48.37 mg/dl, p= 0.020), and glucose levels (5.25±0.87 mmol/L vs. 5.04±0.62 mmol/L, p= 0.007). It seemed that PCa patients had a more severe inflammatory status, but this difference was not significant. However, no significant difference in PCa development was found for either the Gleason score or its extension.

Conclusion

PCa seems to be related to a more severe inflammatory status and more active metabolism, and lipid abnormalities are the main cause of prostate cancer, but the causal relationships between lipids and prostate cancer are still unclear and need further research.
Sparse modeling of dominant factors affecting porosity formation in laser powder bed fusion of aluminum alloy
Authors: Goto Ikuzo , Tsuchida Natsumi , Kawahara Masaaki
Published: July 2024

The dominant factors affecting porosity formation in laser powder bed fusion (PBF-LB/M) of an aluminum alloy were investigated through sparse modeling with the cross-sectional pore area ratio as the target variable and the process parameters of PBF-LB/M and the melting and solidification conditions of the alloy as the explanatory variables. A combination of a few explanatory variables that did not significantly increase the mean squared error for the relationship between the measured pore area ratios and the ratios estimated via the regression equations was found through lasso regression and backward elimination, which indicated that the energy density (one of the process parameters) and melt-pool depth (one of the melting conditions) were the dominant factors affecting the pore area ratio. The obtained regression coefficients for the energy density and melt-pool depth were negative and positive, respectively. In addition, the relationship between the energy density and melt-pool depth was curvilinear. These results suggest not only that the pore area ratio increases with the energy density and melt-pool depth but also that it decreases with an increase in the energy density or a decrease in the change rate of the pool depth under the range of the slow increase in the pool depth with an increase in the energy density.
Importance of pseudoaneurysms after TAVI – a retrospective analysis of 2063 patients
Authors: Wischmann Patricia , Stern Manuel , Baasen Sven , Schillings Miriam , Schremmer Johanna , Oliver Stern Marc , Klein Kathrin , Jung Christian , Zeus Tobias , Heiss Christian , Kelm Malte , Busch Lucas
Published: July 2024

Summary: Background: Bifemoral arterial access is common in patients undergoing transcatheter aortic valve implantation (TAVI), with a primary treatment access (TAVI access) and a secondary non-TAVI access. Pseudoaneurysm (PSA) is an important complication of femoral arterial puncture. Major vascular complications after TAVI are well described, but little is known about PSA. Patients and methods: A total of 2063 patients underwent transfemoral TAVI between January 2014 and January 2020. Vascular ultrasound of the common femoral artery was assessed before and after TAVI. We compared patient characteristics, periprocedural risk scores, procedural characteristics, and access site bleeding events according to Valve Academic Research Consortium 3 (VARC-3) criteria, length of stay (LOS), and all-cause mortality at one year between patients with (46) and without (2017) PSA. Results: The incidence of PSA after TAVI was 2.2% (46/2063). All PSA were successfully treated with ultrasound-guided manual compression (UGMC) or thrombin injection (UGTI) without complications. Patients with PSA had lower platelet counts (210×1000/μl vs. 234×1000/μl; p<0.05), more heart failure symptoms on admission (91% vs. 25%; p<0.05), were more often treated with (N)OACs for atrial fibrillation (AF; 54% vs. 38%; p <0.05), and were less often treated with aspirin (35% vs. 51%; p<0.03). Multivariate analysis identified secondary access site (odds ratio [OR] 8.11; p<0.001) and (N)OAC therapy (OR 1.31; p = 0.037) as risk factors for PSA development. PSA is associated with VARC-3 type 1-3 access site bleeding and longer LOS (15.2 ± 11.3 d vs. 11.6 ± 8.9 d; p<0.01), but this did not affect one year mortality (17% vs. 14%; p = 0.53). Conclusions: Pseudoaneurysms are an important complication after TAVI and are associated with access site bleeding and prolonged hospital stay. (N)OAC therapy and secondary access are important risk factors. Pseudoaneurysms can be safely and effectively treated with thrombin injection and do not affect one-year mortality.
Spatial Structure of the Radio‐Frequency Noise Field in a Large City
Authors: Meyer Aaron C. , Breton Daniel J. , Kamrath Matthew J. , Vecherin Sergey N.
Published: July 2024

The urban radio‐frequency (RF) noise generated by our cities continues to change with time. Although models exist to describe the RF noise as functions of frequency and urban land use types, very few models describe the spatial character or structure of the noise on the scales of city blocks (50–150 m). The goal of this work is to investigate the connection between urban morphology and the higher‐order spatial statistics of the noise field. To achieve this goal, a large measurement campaign was conducted in Boston, Massachusetts. Many spatial measurements allowed for calculation of spatial correlation functions of noise power in three different neighborhoods, which were used to quantify the spatial structure of the fields. A statistical point source model is then developed, with adjustable parameters relating to urban morphology. Good agreement between the model and the experimental correlation functions suggests the 25 MHz urban noise field is well described by a random network of fixed point sources, radiating with a 1/r power law behavior.
Quantifying Compound and Nonlinear Effects of Hurricane‐Induced Flooding Using a Dynamically Coupled Hydrological‐Ocean Model
Authors: Bao Daoyang , Xue Z. George , Warner John C.
Published: July 2024

We recently developed a dynamically coupled hydrological‐ocean modeling system that provides seamless coverage across the land‐ocean continuum during hurricane‐induced compound flooding. This study introduced a local inertial equation and a diagonal flow algorithm to the overland routing of the coupled system’s hydrology model (WRF‐Hydro). Using Hurricane Florence (2018) as a test case, the performance of the coupled model was significantly improved, evidenced by its enhanced capability of capturing backwater and increased water level simulation accuracy and stability. With four model experiments, we present a framework to detangle, define, and quantify compound and nonlinear effects. The results revealed that the flood peaks in the lower Cape Fear River Basin and the coastal waters were contributed by inland flooding and storm surge, respectively. These two processes had comparable contributions to the flooding in the Cape Fear River Estuary. The compound effect was identified when the flood levels resulting from the combination of land and ocean processes surpassed those caused by an individual process alone. The compound effect during Hurricane Florence exhibited limited impact on flood peaks, primarily due to the time lag between the peaks of the storm surge and the inland flooding. In the period between the two peaks, the compound effect was salient and significantly impacted the magnitude and variation of the flood level. The nonlinear effect, defined as the difference between the compound flood level and the superposition of storm surge and inland flooding water levels, reduced flood levels in the river channels while increasing flood levels on the floodplain.
Quantifying the Role of EMIC Wave Scattering During the 27 February 2014 Storm by RAM‐SCB Simulations
Authors: Lyu Xingzhi , Jordanova Vania K. , Engel Miles , Tu Weichao , Ma Qianli
Published: July 2024

Electromagnetic Ion Cyclotron (EMIC) wave scattering has been proved to be responsible for the fast loss of both radiation belt (RB) electrons and ring current (RC) protons. However, its role in the concurrent dropout of these two co‐located populations remains to be quantified. In this work, we study the effect of EMIC wave scattering on both populations during the 27 February 2014 storm by employing the global physics‐based RAM‐SCB model. Throughout this storm event, MeV RB electrons and 100s keV RC protons experienced simultaneous dropout following the occurrence of intense EMIC waves. By implementing data‐driven initial and boundary conditions, we perform simulations for both populations through the interplay with EMIC waves and compare them against Van Allen Probes observations. The results indicate that by including EMIC wave scattering loss, especially by the He‐band EMIC waves, the model aligns closely with data for both populations. Additionally, we investigate the simulated pitch angle distributions (PADs) for both populations. Including EMIC wave scattering in our model predicts a 90° peaked PAD for electrons with stronger losses at lower pitch angles, while protons exhibit an isotropic PAD with enhanced losses at pitch angles above 40°. Furthermore, our model predicts considerable precipitation of both particle populations, predominantly confined to the afternoon to midnight sector (12 hr < MLT < 24 hr) during the storm's main phase, corresponding closely with the presence of EMIC waves.
A Diffusion‐Based Uncertainty Quantification Method to Advance E3SM Land Model Calibration
Authors: Lu Dan , Liu Yanfang , Zhang Zezhong , Bao Feng , Zhang Guannan
Published: July 2024

Calibrating land surface models and accurately quantifying their uncertainty are crucial for improving the reliability of simulations of complex environmental processes. This, in turn, advances our predictive understanding of ecosystems and supports climate‐resilient decision‐making. Traditional calibration methods, however, face challenges of high computational costs and difficulties in accurately quantifying parameter uncertainties. To address these issues, we develop a diffusion‐based uncertainty quantification (DBUQ) method. Unlike conventional generative diffusion methods, which are computationally expensive and memory‐intensive, DBUQ innovates by formulating a parameterized generative model and approximates this model through supervised learning, which enables quick generation of parameter posterior samples to quantify its uncertainty. DBUQ is effective, efficient, and general‐purpose, making it suitable for site‐specific ecosystem model calibration and broadly applicable for parameter uncertainty quantification across various earth system models. In this study, we applied DBUQ to calibrate the Energy Exascale Earth System Model land model at the Missouri Ozark AmeriFlux forest site. Results indicated that DBUQ produced accurate parameter posterior distributions similar to those from Markov Chain Monte Carlo sampling but with 30 times less computing time. This significant improvement in efficiency suggests that DBUQ can enable rapid, site‐level model calibration at a global scale, enhancing our predictive understanding of climate impacts on terrestrial ecosystems.
Molecular relapse after first-line intensive therapy in patients with CBF or NPM1-mutated acute myeloid leukemia – a FILO study
Authors: Orvain Corentin , Bertoli Sarah , Peterlin Pierre , Desbrosses Yohann , Dumas Pierre-Yves , Iat Alexandre , Hospital Marie-Anne , Carre Martin , Tavernier Emmanuelle , Riou Jérémie , Bouvier Anne , Bidet Audrey , Tondeur Sylvie , Renosi Florian , Mozziconacci Marie-Joelle , Flandrin-Gresta Pascale , Dadone-Montaudié Bérengère , Delabesse Eric , Pigneux Arnaud , Hunault-Berger Mathilde , Recher Christian
Published: July 2024

Patients with Core-Binding Factor (CBF) and NPM1-mutated acute myeloid leukemia (AML) can be monitored by quantitative PCR after having achieved first complete remission (CR) to detect morphologic relapse and drive preemptive therapy. How to best manage these patients is unknown. We retrospectively analyzed 303 patients with CBF and NPM1-mutated AML, aged 18–60 years, without allogeneic hematopoietic cell transplantation (HCT) in first CR, with molecular monitoring after first-line intensive therapy. Among these patients, 153 (51%) never relapsed, 95 (31%) had molecular relapse (53 received preemptive therapy and 42 progressed to morphologic relapse at salvage therapy), and 55 (18%) had upfront morphologic relapse. Patients who received preemptive therapy had higher OS than those who received salvage therapy after having progressed from molecular to morphologic relapse and those with upfront morphologic relapse (three-year OS: 78% vs. 51% vs. 51%, respectively, P = 0.01). Preemptive therapy included upfront allogeneic HCT (n = 19), intensive chemotherapy (n = 21), and non-intensive therapy (n = 13; three-year OS: 92% vs. 79% vs. 58%, respectively, P = 0.09). Although not definitive due to the non-randomized allocation of patients to different treatment strategies at relapse, our study suggests that molecular monitoring should be considered during follow-up to start preemptive therapy before overt morphologic relapse.
Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance
Authors: Insanally Michele N. , Albanna Badr F. , Toth Jade , DePasquale Brian , Fadaei Saba Shokat , Gupta Trisha , Lombardi Olivia , Kuchibhotla Kishore , Rajan Kanaka , Froemke Robert C.
Published: July 2024

Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ responses to irregular ‘non-classically responsive’ firing. While a continuum of response properties is observed across neural systems, little is known about the synaptic origins and contributions of diverse responses to network function, perception, and behavior. To capture the heterogeneous responses measured from auditory cortex of rodents performing a frequency recognition task, we use a novel task-performing spiking recurrent neural network incorporating spike-timing-dependent plasticity. Reliable and irregular units contribute differentially to task performance via output and recurrent connections, respectively. Excitatory plasticity shifts the response distribution while inhibition constrains its diversity. Together both improve task performance with full network engagement. The same local patterns of synaptic inputs predict spiking response properties of network units and auditory cortical neurons from in vivo whole-cell recordings during behavior. Thus, diverse neural responses contribute to network function and emerge from synaptic plasticity rules.
Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss
Authors: Sonehara Kyuto , Yano Yoshitaka , Naito Tatsuhiko , Goto Shinobu , Yoshihara Hiroyuki , Otani Takahiro , Ozawa Fumiko , Kitaori Tamao ,   the Biobank Japan Project, Yamanashi Yuji , Furukawa Yoichi , Morisaki Takayuki , Murakami Yoshinori , Kamatani Yoichiro , Muto Kaori , Nagai Akiko , Nakamura Yusuke , Obara Wataru , Yamaji Ken , Takahashi Kazuhisa , Asai Satoshi , Takahashi Yasuo , Higashiue Shinichi , Kobayashi Shuzo , Yamaguchi Hiroki , Nagata Yasunobu , Wakita Satoshi , Nito Chikako , Iwasaki Yu-ki , Murayama Shigeo , Yoshimori Kozo , Miki Yoshio , Obata Daisuke , Higashiyama Masahiko , Masumoto Akihide , Koga Yoshinobu , Koretsune Yukihiro , Matsuda Koichi , Nishiyama Takashi , Okada Yukinori , Sugiura-Ogasawara Mayumi
Published: July 2024

Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry. We detect significant associations in the major histocompatibility complex (MHC) region at 6p21 (lead variant=rs9263738; P = 1.4 × 10−10; odds ratio [OR] = 1.51 [95% CI: 1.33–1.72]; risk allele frequency = 0.871). The MHC associations are fine-mapped to the classical HLA alleles, HLA-C*12:02, HLA-B*52:01, and HLA-DRB1*15:02 (P = 1.1 × 10−10, 1.5 × 10−10, and 1.2 × 10−9, respectively), which constitute a population-specific common long-range haplotype with a protective effect (P = 2.8 × 10−10; OR = 0.65 [95% CI: 0.57–0.75]; haplotype frequency=0.108). Genome-wide copy-number variation (CNV) calling demonstrates rare predicted loss-of-function (pLoF) variants of the cadherin-11 gene (CDH11) conferring the risk of uRPL (P = 1.3 × 10−4; OR = 3.29 [95% CI: 1.78–5.76]). Our study highlights the importance of reproductive immunology and rare variants in the uRPL etiology.
ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis
Authors: Du Jiahui , Liu Yili , Sun Jinrui , Yao Enhui , Xu Jingyi , Wu Xiaolin , Xu Ling , Zhou Mingliang , Yang Guangzheng , Jiang Xinquan
Published: July 2024

Chromatin remodeler ARID1A regulates gene transcription by modulating nucleosome positioning and chromatin accessibility. While ARID1A-mediated stage and lineage-restricted gene regulation during cell fate canalization remains unresolved. Using osteoclastogenesis as a model, we show that ARID1A transcriptionally safeguards the osteoclast (OC) fate canalization during proliferation-differentiation switching at single-cell resolution. Notably, ARID1A is indispensable for the transcriptional apparatus condensates formation with coactivator BRD4/lineage-specifying transcription factor (TF) PU.1 at Nfatc1 super-enhancer during safeguarding the OC fate canalization. Besides, the antagonist function between ARID1A-cBAF and BRD9-ncBAF complex during osteoclastogenesis has been validated with in vitro assay and compound mutant mouse model. Furthermore, the antagonistic function of ARID1A-“accelerator” and BRD9-“brake” both depend on coactivator BRD4-“clutch” during osteoclastogenesis. Overall, these results uncover sophisticated cooperation between chromatin remodeler ARID1A, coactivator, and lineage-specifying TF at super-enhancer of lineage master TF in a condensate manner, and antagonist between distinct BAF complexes in the proper and balanced cell fate canalization.
Bionic e-skin with precise multi-directional droplet sliding sensing for enhanced robotic perception
Authors: Xu Yunlong , Sun Zhongda , Bai Zhiqing , Shen Hua , Wen Run , Wang Fumei , Xu Guangbiao , Lee Chengkuo
Published: July 2024

Electronic skins with deep and comprehensive liquid information detection are desired to endow intelligent robotic devices with augmented perception and autonomous regulation in common droplet environments. At present, one technical limitation of electronic skins is the inability to perceive the liquid sliding information as realistically as humans and give feedback in time. To this critical challenge, in this work, a self-powered bionic droplet electronic skin is proposed by constructing an ingenious co-layer interlaced electrode network and using an overpass connection method. The bionic skin is used for droplet environment reconnaissance and converts various dynamic droplet sliding behaviors into electrical signals based on triboelectricity. More importantly, the two-dimensional sliding behavior of liquid droplets is comprehensively perceived by the e-skin and visually fed back in real-time on an indicator. Furthermore, the flow direction warning and intelligent closed-loop control of water leakage are also achieved by this e-skin, achieving the effect of human neuromodulation. This strategy compensates for the limitations of e-skin sensing droplets and greatly narrows the gap between artificial e-skins and human skins in perceiving functions.
Non-technological barriers: the last frontier towards AI-powered intelligent optical networks
Authors: Khan Faisal Nadeem
Published: July 2024

Machine learning (ML) has been remarkably successful in transforming numerous scientific and technological fields in recent years including computer vision, natural language processing, speech recognition, bioinformatics, etc. Naturally, it has long been considered as a promising mechanism to fundamentally revolutionize the existing archaic optical networks into next-generation smart and autonomous entities. However, despite its promise and extensive research conducted over the last decade, the ML paradigm has so far not been triumphant in achieving widespread adoption in commercial optical networks. In our perspective, this is primarily due to non-addressal of a number of critical non-technological issues surrounding ML-based solutions’ development and use in real-world optical networks. The vision of intelligent and autonomous fiber-optic networks, powered by ML, will always remain a distant dream until these so far neglected factors are openly confronted by all relevant stakeholders and categorically resolved.
Selective nitrogen insertion into aryl alkanes
Authors: Zhang Zheng , Li Qi , Cheng Zengrui , Jiao Ning , Zhang Chun
Published: July 2024

Molecular structure-editing through nitrogen insertion offers more efficient and ingenious pathways for the synthesis of nitrogen-containing compounds, which could benefit the development of synthetic chemistry, pharmaceutical research, and materials science. Substituted amines, especially nitrogen-containing alkyl heterocyclic compounds, are widely found in nature products and drugs. Generally, accessing these compounds requires multiple steps, which could result in low efficiency. In this work, a molecular editing strategy is used to realize the synthesis of nitrogen-containing compounds using aryl alkanes as starting materials. Using derivatives of O-tosylhydroxylamine as the nitrogen source, this method enables precise nitrogen insertion into the Csp2-Csp3 bond of aryl alkanes. Notably, further synthetic applications demonstrate that this method could be used to prepare bioactive molecules with good efficiency and modify the molecular skeleton of drugs. Furthermore, a plausible reaction mechanism involving the transformation of carbocation and imine intermediates has been proposed based on the results of control experiments.
Machine learning aided design of single-atom alloy catalysts for methane cracking
Authors: Sun Jikai , Tu Rui , Xu Yuchun , Yang Hongyan , Yu Tie , Zhai Dong , Ci Xiuqin , Deng Weiqiao
Published: July 2024

The process of CH4 cracking into H2 and carbon has gained wide attention for hydrogen production. However, traditional catalysis methods suffer rapid deactivation due to severe carbon deposition. In this study, we discover that effective CH4 cracking can be achieved at 450 °C over a Re/Ni single-atom alloy via ball milling. To explore single-atom alloy catalysis, we construct a library of 10,950 transition metal single-atom alloy surfaces and screen candidates based on C–H dissociation energy barriers predicted by a machine learning model. Experimental validation identifies Ir/Ni and Re/Ni as top performers. Notably, the non-noble metal Re/Ni achieves a hydrogen yield of 10.7 gH2 gcat–1 h–1 with 99.9% selectivity and 7.75% CH4 conversion at 450 °C, 1 atm. Here, we show the mechanical energy boosts CH4 conversion clearly and sustained CH4 cracking over 240 h is achieved, significantly surpassing other approaches in the literature.