bluuebunny/crossref_metadata_2025 huggingface dataset:
18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma
Authors: Luo Zhe-Huang , Luo Xiao-Yan , Qi Wan-Ling , Liu Qian
Published: February 2024

Background

Pulmonary sarcomatoid carcinoma (PSC) is a rare highly aggressive and poorly differentiated non-small cell carcinoma, and little is known about the information on the usefulness of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). We investigated the clinical and 18F-FDG PET/CT features of PSC.

Methods

We retrospectively analyzed 25 consecutive PSC patients who had undergone 18F-FDG PET/CT. Demographic data, PET/CT findings before treatment, pathological features, and prognosis in these patients were investigated to define correlates between maximal standard uptake value (SUVmax) and clinicopathological parameters.

Results

From March 2017 to January 2023, twenty-five eligible patients with PSC were identified. There were 23 (92%) men, aged 68.5 ± 8.5 (range 56-90) years. Eighteen (72%) patients had a frequent smoking history. The mean size of PSCs was 59.3 ± 18.6 (range 29-97) mm, and 23 (92%) PSCs were Stage IV tumors. 20 (80%) lesions were located in the upper lung and 19 (76%) cases belonged to the peripheral type. Necrotic foci appeared in 21(84%) tumors. 11 (44%) PSCs invaded the pleura. All PSCs were FDG avid, and the mean of SUVmax was 11.8 ± 5.3 (range 4.8-25.5). Metastases were found on PET/CT in 24(96%) patients. The SUVmax of the lesions ≥ 5cm was higher than that of the lesions < 5cm (p=0.004), and the SUVmax of lesions with TTF-1 expression was higher than those of lesions without TTF-1 expression (p=0.009). All of the 25 primary lesions were considered malignant and confirmative, probable, and possible diagnosis of PSC was made in 2 (8%), 4 (16%), and 5(20%) patients, respectively on PET/CT. PSC was not considered in 14 (56%) patients, in PET/CT. The survival of patients with surgery didn’t demonstrate a significantly good prognosis as compared with those without surgery (p=0.675).

Conclusion

All PSCs had obvious FDG avidity. Although imaging diagnosis is still difficult, combined clinical and imaging features more than 40% of primary lesions were considered for the possibility of PSC in our group. Early histopathological diagnosis is necessary to help develop a reasonable regimen.
Pediatric obstructive sleep apnea diagnosis: leveraging machine learning with linear discriminant analysis
Authors: Qin Han , Zhang Liping , Li Xiaodan , Xu Zhifei , Zhang Jie , Wang Shengcai , Zheng Li , Ji Tingting , Mei Lin , Kong Yaru , Jia Xinbei , Lei Yi , Qi Yuwei , Ji Jie , Ni Xin , Wang Qing , Tai Jun
Published: February 2024

Objective

The objective of this study was to investigate the effectiveness of a machine learning algorithm in diagnosing OSA in children based on clinical features that can be obtained in nonnocturnal and nonmedical environments.

Patients and methods

This study was conducted at Beijing Children's Hospital from April 2018 to October 2019. The participants in this study were 2464 children aged 3–18 suspected of having OSA who underwent clinical data collection and polysomnography(PSG). Participants’ data were randomly divided into a training set and a testing set at a ratio of 8:2. The elastic net algorithm was used for feature selection to simplify the model. Stratified 10-fold cross-validation was repeated five times to ensure the robustness of the results.

Results

Feature selection using Elastic Net resulted in 47 features for AHI ≥5 and 31 features for AHI ≥10 being retained. The machine learning model using these selected features achieved an average AUC of 0.73 for AHI ≥5 and 0.78 for AHI ≥10 when tested externally, outperforming models based on PSG questionnaire features. Linear Discriminant Analysis using the selected features identified OSA with a sensitivity of 44% and specificity of 90%, providing a feasible clinical alternative to PSG for stratifying OSA severity.

Conclusions

This study shows that a machine learning model based on children's clinical features effectively identifies OSA in children. Establishing a machine learning screening model based on the clinical features of the target population may be a feasible clinical alternative to nocturnal OSA sleep diagnosis.
Investigating the immune mechanism of natural products in the treatment of lung cancer
Authors: Yang Lian , Chen Yukun , Liu Kaile , Chen Yuanyuan , Zhang Yu , Zhang Zhanxia , Li Hegen
Published: February 2024

With the deepening of people’s understanding of lung cancer, the research of lung cancer immunotherapy has gradually become the focus of attention. As we all know, the treatment of many diseases relies on the rich sources, complex and varied compositions and wide range of unique biological properties of natural products. Studies have shown that natural products can exert anticancer effects by inducing tumor cell death, inhibiting tumor cell proliferation, and enhancing tumor cell autophagy. More notably, natural products can adjust and strengthen the body’s immune response, which includes enhancing the function of NK cells and promoting the differentiation and proliferation of T lymphocytes. In addition, these natural products may enhance their anticancer effects by affecting inhibitory factors in the immune system, hormone levels, enzymes involved in biotransformation, and modulating other factors in the tumor microenvironment. The importance of natural products in lung cancer immunotherapy should not be underestimated. However, the specific links and correlations between natural products and lung cancer immunity are not clear enough, and further studies are urgently needed to clarify the relationship between the two. In this paper, we will focus on the correlation between natural products and lung cancer immune responses, with a view to providing new research perspectives for immunotherapy of lung cancer.
Overexpression of miR-506-3p reversed doxorubicin resistance in drug-resistant osteosarcoma cells
Authors: Wang Xinru , Ding Rumeng , Fu Zhe , Yang Meng , Li Duolu , Zhou Yubing , Qin Chongzhen , Zhang Wenda , Si Liuzhe , Zhang Jingmin , Chai Yuna
Published: February 2024

Background and objective: Osteosarcoma is a common primary malignant tumor of bone, and doxorubicin is one of the most widely used therapeutic drugs. While the problem of doxorubicin resistance limits the long-term treatment benefits in osteosarcoma patients. The role of miRNAs and their target genes in osteosarcoma have become increasingly prominent. Currently, there is no report on miR-506-3p reversing doxorubicin resistance by targeting STAT3 in osteosarcoma. The purpose of this study was to investigate the molecular mechanism that overexpression of miR-506-3p reverses doxorubicin resistance in drug-resistant osteosarcoma cells.

Methods: Doxorubicin-resistant osteosarcoma cells (U-2OS/Dox) were constructed by intermittent stepwise increasing stoichiometry. The target genes of miR-506-3p were predicted by bioinformatics approach and the targeting relationship between miR-506-3p and STAT3 was detected using dual luciferase reporter assay. U-2OS/Dox cells were treated with miR-506-3p overexpression and STAT3 silencing respectively. Then Western blot and RT-qPCR were used to detect the protein and mRNA expression levels of JAK2/STAT3 signaling pathway, drug-resistant and apoptotic associated molecules. The migration and invasion were assessed by cell scratch assay and transwell assay. The cell proliferative viability and apoptosis were investigated by CCK8 assay and flow cytometry assay.

Results: U-2OS/Dox cells were successfully constructed with a 14.4-fold resistance. MiR-506-3p is directly bound to the 3′-UTR of STAT3 mRNA. Compared with U-2OS cells, the mRNA expression of miR-506-3p was reduced in U-2OS/Dox cells. Overexpression of miR-506-3p decreased the mRNA expression levels of JAK2, STAT3, MDR1/ABCB1, MRP1/ABCC1, Survivin and Bcl-2, and decreased the protein expression levels of p-JAK2, STAT3, MDR1/ABCB1, MRP1/ABCC1, Survivin and Bcl-2, and conversely increased Bax expression. It also inhibited the proliferation, migration and invasion of U-2OS/Dox cells and promoted cells apoptosis. The results of STAT3 silencing experiments in the above indicators were consistent with that of miR-506-3p overexpression.

Conclusion: Overexpression of miR-506-3p could inhibit the JAK2/STAT3 pathway and the malignant biological behaviors, then further reverse doxorubicin resistance in drug-resistant osteosarcoma cells. The study reported a new molecular mechanism for reversing the resistance of osteosarcoma to doxorubicin chemotherapy and provided theoretical support for solving the clinical problems of doxorubicin resistance in osteosarcoma.
Oxygen-supplying ROS-responsive prodrug for synergistic chemotherapy and photodynamic therapy of colon cancer
Authors: Hao Ying , Liu Tailuo , Zhou Hao , Xu Runhao , Li Ka , Chen Mao , Chen Yuwen
Published: February 2024

Introduction: The synergistic treatment of chemotherapy and photodynamic therapy (PDT) has remarkable potential in cancer therapy. However, challenges remain, such as unstable chemotherapeutic drug release, suboptimal targeting, and reduced efficacy of PDT under hypoxic conditions commonly found in solid tumors.

Methods: To address these issues, we use camptothecin (CPT) and pheophorbide a (Pa) incorporated through the functional thioketal, which serves as the reactive oxygen species (ROS)-responsive trigger, to construct a ROS-responsive prodrug (CPT-TK-Pa). Subsequently, we co-loaded it with a platinum nanozyme (PtNP) in distearylphosphatidylethanolamine–polyethylene glycol (DSPE–PEG) to obtain the ROS-responsive prodrug nanoparticle (CPT-TK-Pa/Pt NP).

Results and Discussion: Specifically, the incorporated PtNP within CPT-TK-Pa/Pt NP positively catalyzes the conversion of hydrogen peroxide (H2O2) to oxygen, thereby ameliorating the hypoxic state of the tumor. This enhanced oxygen generation could replenish the oxygen that is consumed by Pa during 660 nm exposure, enabling controlled CPT release and amplifying the photodynamic response. In vitro investigations reveal the potency of CPT-TK-Pa/Pt NPs in inhibiting colon tumor cells. Given its ROS-responsive release mechanism and enhanced PDT efficacy, CPT-TK-Pa/Pt NP has the potential to be a promising candidate for cancer therapy.
Polyphenols and extracts from Zingiber roseum (Roxb.) Roscoe leaf mitigate pain, inflammation and pyrexia by inhibiting cyclooxygenase-2: an in vivo and in silico studies
Authors: Ahmed Shakhawat , Ahmed Khondoker Shahin , Rahman Md. Naiemur , Hossain Hemayet , Han Aixia , Geng Peiwu , Daula A. F. M. Shahid Ud , Mamun Abdullah Al
Published: February 2024

Zingiber roseum (Roxb.) Roscoe, a perennial herb from the Zingiberaceae family, has a long history of traditional use in the treatment of several ailments including pain, inflammation, fever, cough, arthritis, skin diseases, and liver infections. This study sought to confirm the efficacy of Zingiber roseum (Roxb.) Roscoe leaves methanol extract (ZrlME) as reported in traditional usage by evaluating its analgesic, anti-inflammatory, and antipyretic capabilities. In addition, in silico molecular docking of the metabolites identified in ZrlME was studied to verify the experimental outcomes. ZrlME demonstrated strong dose-dependent analgesic efficacy against all analgesic tests. ZrlME (400 mg/kg) showed higher anti-inflammatory activity than the standard in the carrageenan-induced paw edema test model. A significant reduction of rectal temperature (3.97°F↓) was also recorded at the same dose of ZrLME after 24 h of treatment. Seven polyphenolic metabolites were identified and quantified by HPLC-DAD analysis, including 3, 4- dihydroxy benzoic acid, (-) epicatechin, rutin hydrate, p-coumaric acid, trans-ferulic acid, rosmarinic acid, and myricetin. Strong binding affinities (ranges from −5.8 to −8.5 Kcal/mol) between the aforesaid polyphenols and cyclooxygenase-2 were discovered. Moreover, molecular dynamics simulations (MDS) demonstrated that these polyphenols exhibit significant COX-2 inhibitory activity due to their high stability in the COX-2 active site. In computational prediction, the polyphenols were also found to be nontoxic, and a variety of biological activities, such as antioxidant, analgesic, anti-inflammatory, antipyretic, and hepatoprotective, were observed. The results of this study revealed that ZrlME possesses notable analgesic, anti-inflammatory, and antipyretic properties.
Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment
Authors: Tang Bin , Zheng Xuwei , Luo Qianqian , Li Xiong , Yang Yujie , Bi Yang , Chen Yonggen , Han Ling , Chen Haiming , Lu Chuanjian
Published: February 2024

Background: Psoriasis, a chronic skin condition characterized by systemic inflammation and altered gut microbiota, has been a target of Traditional Chinese Medicine (TCM) for centuries. Shenling Baizhu Powder (SLBZP), a TCM formulation, holds promise for treating inflammatory diseases, but its specific role in psoriasis and impact on gut microbiota is not fully understood.

Objective: This study aims to elucidate the mechanism of SLBZP in treating psoriasis, integrating component analysis, network pharmacology, and experimental validation in mice models.

Methods: We commenced with a detailed component analysis of SLBZP using liquid chromatograph and mass spectrometer (LC-MS). Network pharmacology analysis was used to predict the potential action targets and pathways of SLBZP in psoriasis. An in vivo experiment was conducted with psoriasis mice models, treated with SLBZP. Therapeutic effects were assessed via symptomatology, histopathology, and immunohistochemical analysis. Gut microbiota composition was analyzed using 16S rRNA gene sequencing.

Results: A total of 42 main components and quality markers were identified, primarily from licorice and ginseng, including flavonoids, saponins and other markers. PPI topology analysis showed that TNF, IL-6, IL-1β, TP53 and JUN were the core DEPs. 168 signaling pathways including lipid and atherosclerosis, AGE-RAGE signaling pathway, IL-17 signaling pathway and Th17 cell differentiation were enriched by KEGG. SLBZP demonstrated significant therapeutic effects on psoriasis in mice, with alterations in skin pathology and biomarkers. Additionally, notable changes in gut microbiota composition were observed post-treatment, indicating a possible gut-skin axis involvement.

Conclusion: This research has pinpointed lipid metabolism as a key pathway in the treatment of psoriasis with SLBZP. It explores how SLBZP’s modulation of gut microbiota and lipid metabolism can alleviate psoriasis, suggesting that balancing gut microbiota may reduce inflammation mediators and offer therapeutic benefits. This underscores lipid metabolism modulation as a potential new strategy in psoriasis treatment.
Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study
Authors: Cao Siyang , Wei Yihao , Yue Yaohang , Chen Yingqi , Liao Shuai , Li Aikang , Liu Peng , Xiong Ao , Zeng Hui
Published: February 2024

In the past 11 years, there has been a surge in studies exploring the regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, a significant gap persists in comprehensive scientometric analysis and scientific mapping research, especially in tracking the evolution, primary contributors, and emerging research focal points. This study aims to comprehensively update the advancements in targeting ferroptosis with various TCMs during the previous 11 years. The data, covering the period from 1 January 2012, to 30 November 2023, were retrieved from the Web of Science database. For in-depth scientometric and visualized analyses, a series of advanced analytical instruments were employed. The findings highlight China’s predominant role, accounting for 71.99% of total publications and significantly shaping research in this domain. Noteworthy productivity was observed at various institutions, including Guangzhou University of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, and Zhejiang University. Thomas Efferth emerged as the foremost author within this field, while Frontiers in Pharmacology boasted the highest publication count. This study pinpointed hepatocellular carcinoma, chemical and drug-induced liver injury, mitochondrial diseases, acute kidney injury, and liver failure as the most critical disorders addressed in this research realm. The research offers a comprehensive bibliometric evaluation, enhancing our understanding of the present status of TCM therapy in managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers and newcomers by accelerating access to vital information and fostering innovative concept extraction within this specialized field.
Selection of M5 mutant lines of wheat (Triticum aestivum L.) for agronomic traits and biomass allocation under drought stress and non-stressed conditions
Authors: Makebe Athenkosi , Shimelis Hussein , Mashilo Jacob
Published: February 2024

Introduction

In the face of climate changes and limited water availability for irrigated crop production, enhanced drought tolerance and adaptation is vital to improve wheat productivity. The objective of this study was to determine the responses of newly bred and advanced mutant lines of wheat based on agronomic traits and biomass allocation under drought-stressed and non-stressed environments for production and breeding.

Methods

Fifty-three mutant lines, including the parental check and six check varieties, were evaluated under non-stressed (NS) and drought stressed (DS) conditions in the field and controlled environments using a 20 x 3 alpha lattice design with two replicates. The following agronomic data were collected: days to 50% heading (DTH), days to maturity (DTM), plant height (PH), number of productive tillers (PTN), shoot biomass (SB), root biomass (RB), total biomass (TB), root: shoot ratio (RSR), spike length (SL), thousand seeds weight (TSW) and grain yield (GY). Data were analyzed and summarized using various statistical procedures and drought tolerance indices were computed based on grain yield under NS and DS conditions.

Results

Significant (P < 0.05) differences were recorded among the mutant lines for most assessed traits under NS and DS conditions. Grain yield positively and significantly (p < 0.001) correlated with PTN (r = 0.85), RB (r = 0.75), SB (r = 0.80), SL (r =0.73), TB (r = 0.65), and TSW (r = 0.67) under DS condition. Principal component analysis revealed three components contributing to 78.55% and 77.21% of the total variability for the assessed agronomic traits under DS and NS conditions, respectively. The following traits: GY, RB, SB, and PTN explained most of the variation with high loading scores under DS condition. Geometric mean productivity (GMP), mean productivity (MP), harmonic mean (HM), and stress tolerance index (STI) were identified as the best drought tolerance indices for the identification of tolerant lines with positive correlations with GY under NS and DS conditions.

Discussion

Among the advanced lines tested, LMA16, LMA37, LMA47, LMA2, and LMA42 were selected as the superior lines with high performance and drought tolerance. The selected lines are recommended for multi-environment trails and release for production in water-limited environments in South Africa.
Heat and salinity stress on the African eggplant F1 Djamba, a Kumba cultivar
Authors: David-Rogeat Noémie , Broadley Martin R. , Stavridou Eleftheria
Published: February 2024

Climate change is expected to increase soil salinity and heat-wave intensity, duration, and frequency. These stresses, often present in combination, threaten food security as most common crops do not tolerate them. The African eggplant (Solanum aethiopicum L.) is a nutritious traditional crop found in sub-Saharan Africa and adapted to local environments. Its wider use is, however, hindered by the lack of research on its tolerance. This project aimed to describe the effects of salinity (100 mM NaCl solution) combined with elevated temperatures (27/21°C, 37/31°C, and 42/36°C). High temperatures reduced leaf biomass while cell membrane stability was reduced by salinity. Chlorophyll levels were boosted by salinity only at the start of the stress with only the different temperatures significantly impacted the levels at the end of the experiment. Other fluorescence parameters such as maximum quantum yield and non-photochemical quenching were only affected by the temperature change. Total antioxidants were unchanged by either stress despite a decrease of phenols at the highest temperature. Leaf sodium concentration was highly increased by salinity but phosphorus and calcium were unchanged by this stress. These findings shed new light on the tolerance mechanisms of the African eggplant under salinity and heat. Further research on later developmental stages is needed to understand its potential in the field in areas affected by these abiotic stresses.
A political psychology of the link between populist beliefs and compliance with COVID-19 containment measures
Authors: Uluşahin Yasemin , Mavor Kenneth , Reicher Stephen
Published: February 2024

This paper addresses the relationship between populist beliefs and compliance with COVID-19 containment measures. We argue that an understanding of this issue depends upon developing a social/political psychology which addresses the impact of social groups and social relations upon behavior. More specifically we propose that populist beliefs are based on the notion that elite authorities are opposed to the people and hence not to be trusted by them which in turn reduces compliance with what they propose. Furthermore, we draw distinctions between different domains of compliance (getting vaccinated, social distancing and complying with “track and trace”) and different forms of authority (politicians and scientists). We argue that, whereas loss of trust in politicians only undermines engagement with forms of compliance which involve direct engagement with political authority (i.e., track and trace) loss of trust in scientists undermines the very belief that there is a pandemic and hence reduces all forms of compliance. We use a survey of 321 English and Welsh respondents to address these arguments. The data provide weak support for the hypothesis that populism has an effect on compliance through trust in politicians but only in the case of participating in track and trace. The data provide stronger support for the hypothesis that populism has an effect on all forms of compliance through trust in scientists, but only when scientists are perceived as part of the elite. Over all these results demonstrate that the ability to understand the complex relationships between populist beliefs and compliance depends on developing a social/political psychology of COVID-19 which is able to explain how human behavior is shaped by social identities and social relationships which, in turn, are shaped by political ideologies.
Neurophysiological correlates of interpersonal discrepancy and social adjustment in an interactive decision-making task in dyads
Authors: Vicente Unai , Ara Alberto , Palacín-Lois María , Marco-Pallarés Josep
Published: February 2024

Introduction

The pursuit of convergence and the social behavioral adjustment of conformity are fundamental cooperative behaviors that help people adjust their mental frameworks to reach a common goal. However, while social psychology has extensively studied conformity by its influence context, there is still plenty to investigate about the neural cognitive mechanisms involved in this behavior.

Methods

We proposed a paradigm with two phases, a pre-activation phase to enhance cooperative tendencies and, later, a social decision-making phase in which dyads had to make a perceptual estimation in three consecutive trials and could converge in their decisions without an explicit request or reward to do so. In Study 1, 80 participants were divided in two conditions. In one condition participants did the pre-activation phase alone, while in the other condition the two participants did it with their partners and could interact freely. In Study 2, we registered the electroencephalographical (EEG) activity of 36 participants in the social decision-making phase.

Results

Study 1 showed behavioral evidence of higher spontaneous convergence in participants who interacted in the pre-activation phase. Event related Potentials (ERP) recorded in Study 2 revealed signal differences in response divergence in different time intervals. Time-frequency analysis showed theta, alpha, and beta evidence related to cognitive control, attention, and reward processing associated with social convergence.

Discussion

Current results support the spontaneous convergence of behavior in dyads, with increased behavioral adjustment in those participants who have previously cooperated. In addition, neurophysiological components were associated with discrepancy levels between participants, and supported the validity of the experimental paradigm to study spontaneous social behavioral adaptation in experimental settings.
Is it possible to identify physical-motor profiles of preschool children on their association with selected biosocial factors?
Authors: Gil-Madrona Pedro , Losada-Puente Luisa , Mendiri Paula , Sá César , Silva Inês P. , Saraiva Linda
Published: February 2024

Biosocial factors play a crucial role in the physical-motor development (PMD) of children during the preschool age. The present study aims to identify physical-motor profiles throughout preschool age (3–6 years) and explore associations between profiles and selected biosocial factors such as age, sex, prematurity, weight, height, BMI, and participation in extracurricular physical activities. Data from 412 typically developing children (46.6% girls and 53.4% boys), aged 35–71 months (M = 51.21, SD = 10.47) was collected using the Psychomotor Activities Checklist and specifically the scale of Psycho-Motor Aspects. Cluster analysis made it possible to define four different childhood PMD profiles. High PMD; High PMD except left laterality; medium-low PMD; and low PMD. High PMD profile includes older children, with anthropometric measurements closer to the WHO recommendations, fewer preterm children, and greater participation in extracurricular physical activities. Low PMD profile includes younger children, with weight slightly above and height slightly below the WHO recommendations and low participation in extracurricular physical activities. This study allows us to identify specific trends that may be decisive for the motor development of children throughout preschool age, highlighting selected biological variables and participation in extracurricular physical activities.
The effect of reading engagement on scientific literacy – an analysis based on the XGBoost method
Authors: Cao Canxi , Zhang Tongxin , Xin Tao
Published: February 2024

Scientific literacy is a key factor of personal competitiveness, and reading is the most common activity in daily learning life, and playing the influence of reading on individuals day by day is the most convenient way to improve the level of scientific literacy of all people. Reading engagement is one of the important student characteristics related to reading literacy, which is highly malleable and is jointly reflected by behavioral, cognitive, and affective engagement, and it is of theoretical and practical significance to explore the relationship between reading engagement and scientific literacy using reading engagement as an entry point. In this study, we used PISA2018 data from China to explore the relationship between reading engagement and scientific literacy with a sample of 15-year-old students in mainland China. 36 variables related to reading engagement and background variables (gender, grade, and socioeconomic and cultural status of the family) were selected from the questionnaire as the independent variables, and the score of the Scientific Literacy Assessment (SLA) was taken as the outcome variable, and supervised machine learning method, the XGBoost algorithm, to construct the model. The dataset is randomly divided into training set and test set to optimize the model, which can verify that the obtained model has good fitting degree and generalization ability. Meanwhile, global and local personalized interpretation is done by introducing the SHAP value, a cutting-edge machine model interpretation method. It is found that among the three major components of reading engagement, cognitive engagement is the more influential factor, and students with high reading cognitive engagement level are more likely to get high scores in scientific literacy assessment, which is relatively dominant in the model of this study. On the other hand, this study verifies the feasibility of the current popular machine learning model, i.e., XGBoost, in a large-scale international education assessment program, with a better model adaptability and conditions for global and local interpretation.
Can a PERMA model-based positive psychological intervention affect the SIA and SWB of vocational college students majoring in nursing in China?
Authors: Yang Jie , Tan Yingchun , Yao Chunlin
Published: February 2024

Aims

The study was conducted to investigate the effects of a PERMA model-based positive psychological intervention on vocational college students’ social interaction anxiety and subjective well-being.

Methods

This is an experimental study in which data were collected through self-administered questionnaire. A total of 261 students from four classes at Caofeidian College of Technology without differences in the levels of social interaction anxiety and subjective well-being were selected as the control group and intervention group randomly. Students in the control group received a traditional psychological intervention, while students in the invention group received a PERMA model-based positive psychological intervention. Thereafter, the research team collected data regarding students’ social interaction anxiety and subjective well-being.

Results

Based on the result obtained, the mean score for social interaction anxiety in the invention group was significantly lower than those in the control group (42.95 vs. 53.07, p < 0.001) and the mean score for subjective well-being was significantly higher than those in the control group (92.58 vs. 87.26, p < 0.001).

Conclusion

A PERMA model-based positive psychological intervention can effectively relieve the social interaction anxiety of nursing students in vocational colleges, and improve their subjective well-being levels.
Virtual reality-assisted cognitive behavioral therapy for patients with alcohol use disorder: a randomized feasibility study
Authors: Thaysen-Petersen Daniel , Hammerum Sigurd Krogh , Vissing Anne-Cathrine , Oestrich Irene Henriette , Nordentoft Merete , Düring Signe Wegmann , Fink-Jensen Anders
Published: February 2024

Introduction

Cognitive behavioral therapy (CBT) is an evidence-based treatment for alcohol use disorder (AUD). Exposure to high-risk situations in virtual reality (VR) has been suggested to have a potential therapeutical benefit, but no previous study has combined VR and CBT for AUD. We aimed to investigate the feasibility of using VR-simulated high-risk environments in CBT-based treatment of AUD.

Methods

We randomized ten treatment-seeking AUD-diagnosed individuals to three sessions of conventional CBT or VR-assisted CBT performed at two outpatient clinics in Denmark. In each session, patients randomized to VR-CBT were exposed to VR-simulations from a restaurant to induce authentic thoughts, emotions, physiological reactions, and craving for CBT purposes. The primary outcome measure was feasibility: Drop-out rate, psychological reactions, and simulator sickness. Secondary outcomes were assessment of preliminary short-term changes in alcohol consumption and craving from baseline to one-week and one-month follow-up. In addition, the study was conducted for training in operationalization of VR equipment, treatment manuals, and research questionnaires.

Results

The majority of patients completed all study visits (90%). VR induced authentic high-risk related thoughts, emotions, and physiological reactions that were considered relevant for CBT by patients and therapists. Four of five patients randomized to VR-CBT experienced cravings during VR simulations, and most of these patients (3/5) experienced mild simulator sickness during VR exposure. The preliminary data showed that patients receiving VR-CBT had more reduction in alcohol consumption than patients receiving conventional CBT at one week- (median 94% vs. 72%) and one-month follow-up (median 98% vs. 55%). Similar results were found regarding changes in cravings.

Conclusion

We demonstrated VR-CBT to be a feasible intervention for patients with AUD which supports continued investigations in a larger randomized clinical trial evaluating the efficacy of VR-CBT.

Clinical trial registration

https://www.clinicaltrials.gov/study/NCT04990765?cond=addiction%20CRAVR&rank=2, identifier NCT05042180.
Assessment of occupational stress among certified registered anesthetists in the Greater Accra region
Authors: Sabblah Dorcas Edem , Salifu Abdulai Mohammed , Owusu Richmond , Bawua Serwaa Akoto
Published: February 2024

Background

Work-related stress is a prevailing concern within the community of Certified Registered Anesthetists (CRAs), significantly impacting both the health and professional performance of these individuals. This study aimed to assess work-related stress and its influencing factors among CRAs practicing in the Greater Accra region was examined.

Methods

Using convenience sampling techniques, data were gathered from 140 participants via a Google form questionnaire distributed through WhatsApp. Descriptive statistics were employed to analyze the collected data, focusing on frequencies and proportions for categorical variables. For continuous variables, bivariate analysis (Chi-square) and ordinal logistic regression were conducted using STATA 16. A p-value <0.05 was considered significant.

Results

Among the 140 CRAs, 20 individuals (14.3%) reported experiencing mild stress levels according to the Weiman Occupational Stress Scale. Approximately 3 out of 4 CRAs (73.6%) reported having moderate stress levels, and 12.1% reported severe stress levels. This indicated that the majority of CRAs experienced moderate levels of stress, which was notably affected by the type of health facility and the use of inadequate or sub-standard equipment in the hospitals.

Conclusion

Based on these findings, the study recommends educational programs and counseling for CRAs to heighten awareness of the demanding nature of their job. Additionally, it suggests the provision of proper resources and standard equipment for CRAs. Facility-level motivation for CRAs is also advised to alleviate their stress. Finally, the study proposes further investigations into the factors contributing to work-related stress among CRAs.
Outcomes of intravesical Bacillus Calmette-Guerin in patients with non-muscle invasive bladder cancer: a retrospective study in Australia
Authors: Pillippu Hewa Chamodi , Della-Fiorentina Stephen , Haghighi Kayvan , Chua Wei , Kok Peey-Sei
Published: February 2024

Introduction

Induction intravesical Bacillus Calmette-Guerin (BCG) followed by maintenance after transurethral resection of bladder tumor, is the standard adjuvant therapy for high-risk non-muscle invasive bladder cancer (NMIBC). There is sparse evidence on the practice of intravesical BCG in Australia. Our aim was to determine the outcomes of intravesical BCG therapy in NMIBC in Southwestern Sydney.

Methods

This was a multi-center retrospective audit of NMIBC patients who received intravesical BCG between January 2008 and June 2020. Data was collected across six tertiary hospitals in South Western Sydney. Primary outcome was disease-free survival (DFS). Secondary outcomes were overall survival (OS), BCG induction and maintenance rates.

Results

Of the 200 eligible patients over 12.5 years, median age was 77 years and 83% were male. Of these, 55%, 4.5%, 35% and 5% were Tis, Ta, T1 and unknown stage, respectively. All patients received induction BCG and 56% received maintenance BCG (range 3-36 months). Completion rate of induction BCG was 91%. Only 9% ceased treatment due to intolerance. The median duration of cystoscopy follow-up was 17 months. After a median follow-up time of 37 months, 55% developed recurrence (29% non-muscle invasive, 32% muscle-invasive disease, 8% distant metastasis). The 1-year and 5-year DFS rates were 72% and 41% (median DFS: 39 months). The 1-year and 5-year OS rates were 98% and 87% (median OS: not reached).

Conclusion

The DFS and OS rates were comparable to previous literature. This provides real-world data to assist future clinical trials in NMIBC.
Gender inequality in the culinary profession in tourism from the perspective of university students with working experiences in culinary
Authors: Türkmendağ Tuba , Karaman Nilgün
Published: February 2024

Gender inequality is a phenomenon that is particularly prevalent in the culinary profession and professional culinary within the tourism sector, especially affecting female employees. The current study is approached in the context of the patriarchal societal structure and the unique characteristics of gender in the labor market in Turkey. In this regard, this study focuses on the views and opinions regarding gender inequality of undergraduate students in gastronomy and culinary arts programs and, associate degree in vocational cooking programs who have previously worked and/or interned in the professional culinary within the tourism sector in Turkey. For this purpose, a quantitative research method has been employed in the study. In order to reveal detailed insights into participants’ evaluations, open-ended questions have also been included in the survey form. The quantitative findings from the study emphasized the importance of issues such as “the approach of managers,” “working hours,” and “promotion pathways” among the situations that cause gender inequality. The importance of “an equal and fair approach to employees,” and “being kind and considerate to staff” were highlighted as essential qualities for being a good leader/head chef. Important factors in supporting the career of female chefs were identified as “equal pay for equal work,” and “ensuring job safety.” Findings obtained from open-ended questions have revealed that female employees are more exposed to gender inequality in the profession. In this context, issues such as “unequal pay, promotion, and working conditions,” “harassment,” “lack of recognition for female employees in the professional culinary,” and “the effects of patriarchal norms” were highlighted. The study contains important findings that can contribute to increasing the representation of female employees in professional culinary within the tourism sector, improving the productivity and competitiveness of businesses, and addressing gender inequality in society.
A bibliometric review study of Michael Burawoy
Authors: Raj Aditya , Sinha Anushka
Published: February 2024

This review article utilizes the technique of citation-based bibliometric analysis to provide a comprehensive understanding of the scholarly contributions made by sociologist Michael Burawoy. The most influential academic articles published by Burawoy were retrieved for analyses. Following this, scholars, journals and institutions that he most frequently collaborated with were traced. Further, country-wise analysis of his scholarship was carried out. Lastly, content analyses of retrieved articles identified prominent thematic domains in sociology to which Burawoy contributed, while temporal analyses helped to identify some emerging research hotspots. Findings reveal that historical and cultural context of Burawoy’s research mostly remained confined to the U.S.A., however, he significantly contributed towards the foundation of sociology in the Global South and studied the ensuing global power imbalances. Contemporary sociological thought remains indebted to Burawoy for his comparative study of industrial relations in the 21st century, and recently, his elaboration upon the need for public sociology has taken the discipline in new intellectual directions that appeals to a broader sociological community.
Aging agricultural labor force, outsourcing service of pest control and biopesticide application: a case study of 10 counties in Fujian Province
Authors: Shen Doudou , Wang Linping , Cai Liangmei
Published: February 2024

Introduction

Under the background of increasingly severe aging of agricultural labor force and relatively slow land circulation, agricultural production outsourcing has become the main means of agricultural modernization. Despite the existence of a voluminous literature on outsourcing service of pest control, little is known about its effect on biopesticides use.

Methods

To fill this knowledge gap, this study uses rice planting data from 1,045 Chinese farm households to analyze the impact of different aging agricultural households and the pest control outsourcing service on the application of biopesticides by using the logit regression model.

Results and Discussion

The study results showed that: (1) Participation in pest control outsourcing services significantly promotes biopesticide application. But this positive effect varied across age groups. (2) Compared with aging households, non-aging farmers tend to use biopesticides. Given this, it is recommended that pay attention to the ecological effect of pest control outsourcing services, strengthen the assistance to the aging labor group in the green pesticide promotion policy, and guide the aged planting decision makers to participate in pest control outsourcing services, thereby effectively improving the sustainable development of green agriculture.
Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature
Authors: Khalaf Mohamed H. , Abdelrahman Husham , El-Menyar Ayman , Afifi Ibrahim , Kloub Ahmad , Al-Hassani Ammar , Rizoli Sandro , Al-Thani Hassan
Published: February 2024

For decades, indocyanine green (ICG) has been available for medical and surgical use. The indications for ICG use in surgery have expanded where guided surgery directed by fluorescence and near-infrared fluorescent imaging offers numerous advantages. Recently, surgeons have reported using ICG operative navigation in the emergency setting, with fluorescent cholangiography being the most common procedure. The utility of ICG also involves real-time perfusion assessment, such as ischemic organs and limbs. The rising use of ICG in surgery can be explained by the ICG's rapid technological evolution, accuracy, ease of use, and great potential to guide precision surgical diagnosis and management. The review aims to summarize the current literature on the uses of ICG in emergency general surgery. It provides a comprehensive and practical summary of the use of ICG, including indication, route of administration, and dosages. To simplify the application of ICG, we subdivided its use into anatomical mapping and perfusion assessment. Anatomical mapping includes the biliary tree, ureters, and bowel. Perfusion assessment includes bowel, pancreas, skin and soft tissue, and gonads. This review provides a reference to emergency general surgeons to aid in implementing ICG in the emergency setting for more enhanced and safer patient care.
Biosecurity measures to control hepatitis E virus on European pig farms
Authors: Dubbert Tamino , Meester Marina , Smith Richard Piers , Tobias Tijs J. , Di Bartolo Ilaria , Johne Reimar , Pavoni Enrico , Krumova-Valcheva Gergana , Sassu Elena Lucia , Prigge Christopher , Aprea Giuseppe , May Hannah , Althof Nadine , Ianiro Giovanni , Żmudzki Jacek , Dimitrova Albena , Alborali Giovanni Loris , D'Angelantonio Daniela , Scattolini Silvia , Battistelli Noemi , Burow Elke
Published: February 2024

Hepatitis E virus (HEV) genotype 3 is a prevalent zoonotic pathogen in European pig farms, posing a significant public health risk primarily through the foodborne route. The study aimed to identify effective biosecurity measures for controlling HEV transmission on pig farms, addressing a critical gap in current knowledge. Utilizing a cross-sectional design, fecal samples from gilts, dry sows, and fatteners were collected on 231 pig farms of all farm types across nine European countries. Real-time RT-PCR was employed to test these samples for HEV. Simultaneously, a comprehensive biosecurity questionnaire captured data on various potential measures to control HEV. The dependent variable was HEV risk, categorized as lower or higher based on the percentage of positive pooled fecal samples on each farm (25% cut-off). The data were analyzed using generalized linear models (one for finisher samples and one for all samples) with a logit link function with country and farm type as a priori fixed factors. The results of the final multivariable models identified key biosecurity measures associated with lower HEV risk, which were the use of a hygienogram in the breeding (OR: 0.06, p = 0.001) and/or fattening area after cleaning (OR: 0.21, p = 0.019), the presence of a quarantine area (OR: 0.29, p = 0.025), testing and/or treating purchased feed against Salmonella (OR: 0.35, p = 0.021), the presence of other livestock species on the farm, and having five or fewer persons in charge of the pigs. Contrary to expectations, some biosecurity measures were associated with higher HEV risk, e.g., downtime of 3 days or longer after cleaning in the fattening area (OR: 3.49, p = 0.005) or mandatory handwashing for farm personnel when changing barn sections (OR: 3.4, p = 0.026). This novel study unveils critical insights into biosecurity measures effective in controlling HEV on European pig farms. The identification of both protective and risk-associated measures contributes to improving strategies for managing HEV and underscores the complexity of biosecurity in pig farming.