bluuebunny/crossref_metadata_2025 huggingface dataset:
Maintenance Therapy for ATM-Deficient Pancreatic Cancer by Multiple DNA Damage Response Interferences after Platinum-Based Chemotherapy
Authors: Roger Elodie , Gout Johann , Arnold Frank , Beutel Alica K. , Müller Martin , Abaei Alireza , Barth Thomas F. E. , Rasche Volker , Seufferlein Thomas , Perkhofer Lukas , Kleger Alexander
Published: September 2020

Personalized medicine in treating pancreatic ductal adenocarcinoma (PDAC) is still in its infancy, albeit PDAC-related deaths are projected to rise over the next decade. Only recently, maintenance therapy with the PARP inhibitor olaparib showed improved progression-free survival in germline BRCA1/2-mutated PDAC patients after platinum-based induction for the first time. Transferability of such a concept to other DNA damage response (DDR) genes remains unclear. Here, we conducted a placebo-controlled, three-armed preclinical trial to evaluate the efficacy of multi-DDR interference (mDDRi) as maintenance therapy vs. continuous FOLFIRINOX treatment, implemented with orthotopically transplanted ATM-deficient PDAC cell lines. Kaplan–Meier analysis, cross-sectional imaging, histology, and in vitro analysis served as analytical readouts. Median overall survival was significantly longer in the mDDRi maintenance arm compared to the maintained FOLFIRINOX treatment. This survival benefit was mirrored in the highest DNA-damage load, accompanied by superior disease control and reduced metastatic burden. In vitro analysis suggests FOLFIRINOX-driven selection of invasive subclones, erased by subsequent mDDRi treatment. Collectively, this preclinical trial substantiates mDDRi in a maintenance setting as a novel therapeutic option and extends the concept to non-germline BRCA1/2-mutant PDAC.
Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration
Authors: Urun Fatma Rabia , Moore Adrian W
Published: September 2020

In neural precursors, cell cycle regulators simultaneously control both progression through the cell cycle and the probability of a cell fate switch. Precursors act in lineages, where they transition through a series of cell types, each of which has a unique molecular identity and cellular behavior. Thus, investigating links between cell cycle and cell fate control requires simultaneous identification of precursor type and cell cycle phase, as well as an ability to read out additional regulatory factor expression or activity. We use a combined FUCCI-EdU labelling protocol to do this, and then apply it to the embryonic olfactory neural lineage, in which the spatial position of a cell correlates with its precursor identity. Using this integrated model, we find the CDKi p27KIP1 has different regulation relative to cell cycle phase in neural stem cells versus intermediate precursors. In addition, Hes1, which is the principle transcriptional driver of neural stem cell self-renewal, surprisingly does not regulate p27KIP1 in this cell type. Rather, Hes1 indirectly represses p27KIP1 levels in the intermediate precursor cells downstream in the lineage. Overall, the experimental model described here enables investigation of cell cycle and cell fate control linkage from a single precursor through to a lineage systems level.
Incorporating Prognostic Biomarkers into Risk Assessment Models and TNM Staging for Prostate Cancer
Authors: Saoud Ragheed , Heidar Nassib Abou , Cimadamore Alessia , Paner Gladell P.
Published: September 2020

In current practice, prostate cancer staging alone is not sufficient to adequately assess the patient’s prognosis and plan the management strategies. Multiple clinicopathological parameters and risk tools for prostate cancer have been developed over the past decades to better characterize the disease and provide an enhanced assessment of prognosis. Herein, we review novel prognostic biomarkers and their integration into risk assessment models for prostate cancer focusing on their capability to help avoid unnecessary imaging studies, biopsies and diagnosis of low risk prostate cancers, to help in the decision-making process between active surveillance and treatment intervention, and to predict recurrence after radical prostatectomy. There is an imperative need of reliable biomarkers to stratify prostate cancer patients that may benefit from different management approaches. The integration of biomarkers panel with risk assessment models appears to improve prostate cancer diagnosis and management. However, integration of novel genomic biomarkers in future prognostic models requires further validation in their clinical efficacy, standardization, and cost-effectiveness in routine application.
A Hot Spot of Olive Biodiversity in the Tunisian Oasis of Degache
Authors: Saddoud Deddabi Olfa , Montemurro Cinzia , Ben Maachia Sihem , Ben Amar Fathi , Fanelli Valentina , Gadaleta Susanna , El Riachy Milad , Chehade Ali , Siblini Mona , Boucheffa Saliha , Miazzi Monica Marilena
Published: September 2020

Tunisia is one of the world’s largest producers of olive oil, and it preserves pools of olive genetic diversity that are still unexplored. A recent prospection and collection program of the National Gene Bank of Tunisia (NGBT) focused on the vast oasis of Degache, in the south west part of Tunisia, where 47 samples were collected and genetically characterized through simple sequence repeat (SSR) markers. Identification and authentication of genotypes were obtained through comparison with reference cultivars belonging to the Olive National Collection of Tunisia (IOC) and with cultivars from Algeria, Italia, Syria and Lebanon. Degache olive genotypes showed large genetic variability, a significant diversity from the reference germplasm, and a clear differentiation from modern varieties. The population structure analysis identified four gene pools characterizing genotypes from different area of origin. Two gene pools appear to be more represented in germplasm from southern Tunisia, where environmental conditions at critical plant development phases, are harsher. This suggests that this germplasm might present traits of adaptation useful for breeding to improve resilience to abiotic stresses. Our results will support ex situ and in situ conservation activities of Tunisian olive germplasm pursued by the National Gene Bank of Tunisia.
The Role of Imaging in Bladder Cancer Diagnosis and Staging
Authors: Galgano Samuel J. , Porter Kristin K. , Burgan Constantine , Rais-Bahrami Soroush
Published: September 2020

Bladder cancer (BC) is the most common cancer of the urinary tract in the United States. Imaging plays a significant role in the management of patients with BC, including the locoregional staging and evaluation for distant metastatic disease, which cannot be assessed at the time of cystoscopy and biopsy/resection. We aim to review the current role of cross-sectional and molecular imaging modalities for the staging and restaging of BC and the potential advantages and limitations of each imaging modality. CT is the most widely available and frequently utilized imaging modality for BC and demonstrates good performance for the detection of nodal and visceral metastatic disease. MRI offers potential value for the locoregional staging and evaluation of muscular invasion of BC, which is critically important for prognostication and treatment decision-making. FDG-PET/MRI is a novel hybrid imaging modality combining the advantages of both MRI and FDG-PET/CT in a single-setting comprehensive staging examination and may represent the future of BC imaging evaluation.
Usage of Terms “Science” and “Scientific Knowledge” in Nature of Science (NOS): Do Their Lexicons in Different Accounts Indicate Shared Conceptions?
Authors: Koponen Ismo T.
Published: September 2020

Nature of science (NOS) has been a central theme in science education and research on it for nearly three decades, but there is still debate on its proper focus and underpinnings. The focal points of these debates revolve around different ways of understanding the terms “science” and “scientific knowledge”. It is suggested here that the lack of agreement is at least partially related to and reflected as a lack of common vocabulary and terminology that would provide a shared basis for finding consensus. Consequently, the present study seeks motivation from the notions of centrality of lexicons in recognizing the identity of disciplinary communities and different schools of thought within NOS. Here, by using a network approach, we investigate how lexicons used by different authors to discuss NOS are confluent or divergent. The lexicons used in these texts are investigated on the basis of a network analysis. The results of the analysis reveal clear differences in the lexicons that are partially related to differences in views, as evident from the debates surrounding the consensus NOS. The most divergent views are related to epistemology, while regarding the practices and social embeddedness of science the lexicons overlap significantly. This suggests that, in consensus NOS, one can find much basis for converging views, with common understanding, where constructive communication may be possible. The basic vocabulary, in the form of a lexicon, can reveal much about the different stances and the differences and similarities between various disciplinary schools. The advantage of such an approach is its neutrality and how it keeps a distance from preferred epistemological positions and views of nature of knowledge.
International Understanding among Nursing and Pharmacy Students in Japan
Authors: Yamamura Shigeo , Inoue Eiko , Miyazawa Junko , Yuyama Kayoko , Terajima Tomoko , Mitsumoto Atsushi
Published: September 2020

The purpose of this research is to establish a model for assessing interest in international understanding among nursing and pharmacy students in Japan. The study design was a cross-sectional survey of nursing and pharmacy students in their first to fourth years at Josai International University. The International Understanding Scale (IUS2000), consisting of four domains (respect for human rights, understanding international culture, awareness of world solidarity, and understanding foreign languages) with 27 items, was used. A path analysis and confirmatory factor analysis were used to model international understanding. The model of international understanding of nursing and pharmacy students was established as the second-order four-factor mode. The international understanding of nursing and pharmacy students was mainly composed of respect for human rights and awareness of world solidarity and was less affected by understanding foreign languages. Nursing students in our study had a higher international understanding than pharmacy students. International understanding was considered relevant to students’ learning about the importance of interprofessional collaboration as well as their interests in global learning environments for healthcare professionals. The relationship between international understanding and future progress in healthcare performance needs to be studied to show the importance of international understanding education.
Experimental Analysis of a Novel Double Damper System with Semi-Active Control
Authors: Gorantiwar Anish , Nalawade Rajvardhan , Nouri Arash , Taheri Saied
Published: September 2020

An experimental study was conducted to compare the performance of an in-house built novel double semi-active damper against a conventional semi-active single damper. Different performance metrics were analyzed, and the performance of the two dampers was evaluated based on these metrics. A Hybrid Skyhook–Groundhook control algorithm was developed and implemented on the variable orifice double damper. The semi-active single damper is governed via two separate control strategies, namely—Skyhook and Groundhook control, respectively. The effectiveness of each algorithm is better understood by adding a normal load on top of the Shock Dyno, thus modifying it to act as a quarter car test rig. The sprung and unsprung acceleration data are collected via the accelerometers mounted on the Shock Dyno through a Data Acquisition System. The results obtained from this experiment provide a strong basis that the semi-active double damper performs better in terms of the comfort cost than that of the commercial semi-active single dampers.
PRIPRO—Privacy Profiles: User Profiling Management for Smart Environments
Authors: Cesconetto Jonas , Augusto Silva Luís , Bortoluzzi Fabricio , Navarro-Cáceres María , A. Zeferino Cesar , R. Q. Leithardt Valderi
Published: September 2020

Smart environments are pervasive computing systems that provide higher comfort levels on daily routines throughout interactions among smart sensors and embedded computers. The lack of privacy within these interactions can lead to the exposure of sensitive data. We present PRIPRO (PRIvacy PROfiles), a management tool that includes an Android application that acts on the user’s smartphone by allowing or blocking resources according to the context, in order to address this issue. Back-end web server processes and imposes a protocol according to the conditions that the user selected beforehand. The experimental results show that the proposed solution successfully communicates with the Android Device Administration framework, and the device appropriately reacts to the expected set of permissions imposed according to the user’s profile with low response time and resource usage.
Incorporating External Knowledge into Unsupervised Graph Model for Document Summarization
Authors: Tang Tiancheng , Yuan Tianyi , Tang Xinhuai , Chen Delai
Published: September 2020

Supervised neural network models have achieved outstanding performance in the document summarization task in recent years. However, it is hard to get enough labeled training data with a high quality for these models to generate different types of summaries in reality. In this work, we mainly focus on improving the performance of the popular unsupervised Textrank algorithm that requires no labeled training data for extractive summarization. We first modify the original edge weight of Textrank to take the relative position of sentences into account, and then combine the output of the improved Textrank with K-means clustering to improve the diversity of generated summaries. To further improve the performance of our model, we innovatively incorporate external knowledge from open-source knowledge graphs into our model by entity linking. We use the knowledge graph sentence embedding and the tf-idf embedding as the input of our improved Textrank, and get the final score for each sentence by linear combination. Evaluations on the New York Times data set show the effectiveness of our knowledge-enhanced approach. The proposed model outperforms other popular unsupervised models significantly.
The Impact of Heat Exchangers’ Constructions on the Melting and Solidification Time of Phase Change Materials
Authors: Radomska Ewelina , Mika Lukasz , Sztekler Karol , Lis Lukasz
Published: September 2020

An application of latent heat thermal energy storage systems with phase change materials seems to be unavoidable in the present world. The latent heat thermal energy storage systems allow for storing excessive heat during low demand and then releasing it during peak demand. However, a phase change material is only one of the components of a latent heat thermal energy storage system. The second part of the latent heat thermal energy storage is a heat exchanger that allows heat transfer between a heat transfer fluid and a phase change material. Thus, the main aim of this review paper is to present and systematize knowledge about the heat exchangers used in the latent heat thermal energy storage systems. Furthermore, the operating parameters influencing the phase change time of phase change materials in the heat exchangers, and the possibilities of accelerating the phase change are discussed. Based on the literature reviewed, it is found that the phase change time of phase change materials in the heat exchangers can be reduced by changing the geometrical parameters of heat exchangers or by using fins, metal foams, heat pipes, and multiple phase change materials. To decrease the phase change material’s phase change time in the tubular heat exchangers it is recommended to increase the number of tubes keeping the phase change material’s mass constant. In the case of tanks filled with spherical phase change material’s capsules, the capsules’ diameter should be reduced to shorten the phase change time. However, it is found that some changes in the constructions of heat exchangers reduce the melting time of the phase change materials, but they increase the solidification time.
Optimization Design of a Rain-Power Utilization System Based on a Siphon and Its Application in a High-Rise Building
Authors: Yu Jiaxin , Wang Jun
Published: September 2020

Rain falling from the sky is viewed as a clean energy source with a great potential, owing to the large amount of it and its zero pollution nature, the fact that it has scattered raindrops, and its characteristic rainfall concentration that promotes extensive research on harvesting and utilization. Here, we introduce a new approach to harvest rainwater on rooftops called the Rain-Power Utilization System, which is composed of an initial rainwater disposal system and multistage energy conversion system. Initial rainwater is discharged into a split-flow pipe due to its poor quality and impurities. Additionally, clean rainwater is accumulated in a storage pipe until the water level reaches a specified height, triggering siphonage for energy conversion. The same process is repeated in other storage pipes connected in series. Function relations among physical and dimension parameters have been established for further studies. A kind of simplified optimization algorithm has been proposed considering the maximum instantaneous power under the constraint of a permitted vacuum and maximum energy generation per unit length to find the model with an optimal height combination (hu, hd). The experimental prototype developed in proportion is used to verify theoretical research and conduct error analysis to establish an equation of annual energy generation for a high-rise building. Without building extra tanks, this paper presents an innovative approach to maximizing the use of energy in rain for high-rise buildings based on a siphon.
The Role of Ionic Liquids in the Lignin Separation from Lignocellulosic Biomass
Authors: Hasanov Isa , Raud Merlin , Kikas Timo
Published: September 2020

Lignin is a natural polymer, one that has an abundant and renewable resource in biomass. Due to a tendency towards the use of biochemicals, the efficient utilization of lignin has gained wide attention. The delignification of lignocellulosic biomass makes its fractions (cellulose, hemicellulose, and lignin) susceptible to easier transformation to many different commodities like energy, chemicals, and materials that could be produced using the biorefinery concept. This review gives an overview of the field of lignin separation from lignocellulosic biomass and changes that occur in the biomass during this process, as well as taking a detailed look at the influence of parameters that lead the process of dissolution. According to recent studies, a number of ionic liquids (ILs) have shown a level of potential for industrial scale production in terms of the pretreatment of biomass. ILs are perspective green solvents for pretreatment of lignocellulosic biomass. These properties in ILs enable one to disrupt the complex structure of lignocellulose. In addition, the physicochemical properties of aprotic and protic ionic liquids (PILs) are summarized, with those properties making them suitable solvents for lignocellulose pretreatment which, especially, target lignin. The aim of the paper is to focus on the separation of lignin from lignocellulosic biomass, by keeping all components susceptible for biorefinery processes. The discussion includes interaction mechanisms between lignocellulosic biomass subcomponents and ILs to increase the lignin yield. According to our research, certain PILs have potential for the cost reduction of LC biomass pretreatment on the feasible separation of lignin.
Vitality and Growth of the Threatened Lichen Lobaria pulmonaria (L.) Hoffm. in Response to Logging and Implications for Its Conservation in Mediterranean Oak Forests
Authors: Bianchi Elisabetta , Benesperi Renato , Brunialti Giorgio , Di Nuzzo Luca , Fačkovcová Zuzana , Frati Luisa , Giordani Paolo , Nascimbene Juri , Ravera Sonia , Vallese Chiara , Paoli Luca
Published: September 2020

Forest logging can be detrimental for non-vascular epiphytes, determining the loss of key components for ecosystem functioning. Legal logging in a Mediterranean mixed oak forest (Tuscany, Central Italy) in 2016 heavily impacted sensitive non-vascular epiphytes, including a large population of the threatened forest lichen Lobaria pulmonaria (L.) Hoffm. This event offered the background for this experiment, where the potential effects of logging in oak forests are simulated by means of L. pulmonaria micro-transplants (thallus fragments <1 cm). Our working hypothesis is that forest logging could negatively influence the growth of the thalli exposed in logged stands compared to those exposed in unlogged stands. One hundred meristematic lobes and 100 non-meristematic fragments are exposed for one year on 20 Turkey oak trees (Quercus cerris), half in a logged and half in an unlogged stand. Chlorophyll (Chl) a fluorescence emission and total chlorophyll content are used as a proxy for the overall vitality of the transplants, while their growth is considered an indicator of long-term effects. Generally, vitality and growth of the transplants in the logged stand are lower than in the unlogged stand. Both vitality and growth vary between the meristematic and non-meristematic fragments, the former performing much better. Hence, irrespective of forest management, meristematic fragments show higher growth rates (0.16–0.18 cm2 year−1) than non-meristematic ones (0.02–0.06 cm2 year−1). Considering that a conservation-oriented management for this species should be tailored at the habitat-level and, especially, at the tree-level, our results suggest that for appropriate conservation strategies, it is necessary to consider the life cycle of the lichen, since the probability of survival of the species may vary, with meristematic fragments having more chance to survive after logging.
Effect of Silviculture on Carbon Pools during Development of a Ponderosa Pine Plantation
Authors: Zhang Jie , Zhang Jianwei , Mattson Kim , Finley Kaelyn
Published: September 2020

Forest stands can be considered as dynamic carbon pools throughout their developmental stages. Silvicultural thinning and initial planting densities for reforestation not only manipulate the structure or composition of vegetation, but also disturb forest floor and soils, which, in turn, influences the dynamics of carbon pools. Understanding these carbon pools both spatially and temporally can provide useful information for land managers to achieve their management goals. Here, we estimated five major carbon pools in experimental ponderosa pine (Pinus ponderosa) plots that were planted to three levels of spacing and where competing vegetation was either controlled (VC) or not controlled (NVC). The objectives were to determine how an early competing vegetation control influences the long-term carbon dynamics and how stand density affects the maximum carbon (C) sequestration for these plantations. We found that planting density did not affect total ecosystem C at either sampling age 28 or 54. Because of competing vegetation ingrowth, the NVC (85 ± 14 Mg ha−1) accumulated greater C than the VC (61 ± 6 Mg ha−1) at age 28. By age 54, the differences between treatments narrow with the NVC (114 ± 11 Mg ha−1) and the VC (106 ± 11 Mg ha−1) as the pines continue to grow relatively faster in the VC when compared to NVC and C of ingrowth vegetation decreased in NVC, presumably due to shading by the overstory pines. The detritus was not significantly different among treatments in either years, although the mean forest floor and soil C was slightly greater in NVC. While NVC appears to sequester more C early on, the differences from the VC were rather subtle. Clearly, as the stands continue to grow, the C of the larger pines of the VC may overtake the total C of the NVC. We conclude that, to manage forests for carbon, we must pay more attention to promoting growth of overstory trees by controlling competing vegetation early, which will provide more opportunities for foresters to create resilient forests to disturbances and store C longer in a changing climate.
Predicting the Outdoor Moisture Performance of Wood Based on Laboratory Indicators
Authors: Emmerich Lukas , Brischke Christian , Sievert Marten , Schulz Manuel S. , Jaeger Anne-Cathrin , Beulshausen Arne , Humar Miha
Published: September 2020

The service life of wood in outdoor use under humid conditions is mainly determined by its material resistance and the exposure situation. Different standards such as EN 350 (2016) point on the relevance of wood’s resistance against moisture for its expected service life. Recently, different standardized but also numerous nonstandardized methods were suggested to test the water permeability of wooden materials. In the context of this study, different European-grown soft- and hardwoods, tropical hardwoods, modified wood and wood treated with water- and oil-borne preservatives were subjected to floating and submersion tests according to CEN/TS 16818 (2018) and different short-term water uptake and release tests. Moisture performance data from field tests with the same materials were analyzed and used to assess the predictive power of different laboratory moisture indicators. The moisture characteristics suggested by CEN/TS 16818 (2018)—rm168 (residual moisture content after water uptake and release processes) and res312 (residue as a percentage of the absorbed moisture)—showed the little potential to predict the outdoor moisture performance of the tested materials. In contrast, the mean moisture content during absorption and desorption (MCmean) predicted well the outdoor moisture performance of the materials under test. Short-term water uptake and release of small specimens also showed high predictive power.
Donnan Contribution and Specific Ion Effects in Swelling of Cationic Hydrogels are Additive: Combined High-Resolution Experiments and Finite Element Modeling
Authors: Žuržul Nataša , Ilseng Arne , Prot Victorien E. , Sveinsson Hrafn M. , Skallerud Bjørn H. , Stokke Bjørn T.
Published: September 2020

Finite element modeling applied to analyze experimentally determined hydrogel swelling data provides quantitative description of the hydrogel in the aqueous solutions with well-defined ionic content and environmental parameters. In the present study, we expand this strategy to analysis of swelling of hydrogels over an extended concentration of salt where the Donnan contribution and specific ion effects are dominating at different regimes. Dynamics and equilibrium swelling were determined for acrylamide and cationic acrylamide-based hydrogels by high-resolution interferometry technique for step-wise increase in NaCl and NaBr concentration up to 2 M. Although increased hydrogel swelling volume with increasing salt concentration was the dominant trend for the uncharged hydrogel, the weakly charged cationic hydrogel was observed to shrink for increasing salt concentration up to 0.1 M, followed by swelling at higher salt concentrations. The initial shrinking is due to the ionic equilibration accounted for by a Donnan term. Comparison of the swelling responses at high NaCl and NaBr concentrations between the uncharged and the cationic hydrogel showed similar specific ion effects. This indicates that the ion non-specific Donnan contribution and specific ion effects are additive in the case where they are occurring in well separated ranges of salt concentration. We develop a novel finite element model including both these mechanisms to account for the observed swelling in aqueous salt solution. In particular, a salt-specific, concentration-dependent Flory–Huggins parameter was introduced for the specific ion effects. This is the first report on finite element modeling of hydrogels including specific ionic effects and underpins improvement of the mechanistic insight of hydrogel swelling that can be used to predict its response to environmental change.
A Reversal of the Association between Education Level and Obesity Risk during Ageing: A Gender-Specific Longitudinal Study in South Korea
Authors: Chung Woojin , Kim Roeul
Published: September 2020

This study aimed to examine and quantify obesity risk across different education levels during ageing using the dataset of a nationally representative longitudinal survey. A total of 45,391 observations of 9991 individuals aged ≥45 years were included in this study. Obesity was defined as a body mass index of ≥25, according to a guideline for Asians by the World Health Organization, and education level was grouped into three categories. Socio-demographics, lifestyles, and health conditions were used as covariates. Adjusted odds ratios and predicted probabilities of obesity were computed and adjusted for a complex survey design. With respect to gender, education level and age were significantly associated with obesity risk, and the association was stronger in women than in men. Furthermore, education level was negatively associated with obesity risk in the middle age in each gender. However, the association became positive in the old age, specifically among highly educated women. Therefore, policy efforts to reduce obesity risk and the resulting education gradients should be established based on studies considering their old age. Further longitudinal studies are required to examine whether these findings are valid in other socio-cultural or economic settings.
Health Impact Assessment of Artisanal and Small-Scale Gold Mining Area in Myanmar, Mandalay Region: Preliminary Research
Authors: Kyaw Win Thiri , Kuang Xiaoxu , Sakakibara Masayuki
Published: September 2020

Increasing artisanal and small-scale gold mining (ASGM) in developing countries has raised health concerns in mining communities. A preliminary health survey was conducted in Thabeikkyin Township, Mandalay Region, Myanmar, in February 2020 to assess the health conditions of an ASGM community. Respiratory function and other clinical assessments were evaluated in miners and non-miners, and participants’ hair was analyzed for heavy metals. Respiratory function of miners was similar to that of non-miners. However, miners’ respiratory function declined with longer mining activity duration. In total, 3 out of 18 miners showed neurological signs and symptoms of chronic mercury intoxication. The median concentration of the hair mercury was significantly higher in miners than non-miners (P = 0.01), and 9 out of 18 miners and 2 out of 11 non-miners showed the warning level of mercury. We found that, despite an association between declining respiratory function and length of time mining, only a minority of miners showed clinical features of chronic mercury intoxication. Further clinical surveys with a larger sample size are necessary to determine the broader health status of this community. In addition, clinical indicators such as pulmonary function tests are recommended as additional criteria for the diagnosis of mercury intoxication.
Association between Presenteeism, Psychosocial Aspects of Work and Common Mental Disorders among Nursing Personnel
Authors: Silva-Costa Aline , Ferreira Pollyana C. S. , Griep Rosane H. , Rotenberg Lucia
Published: September 2020

Presenteeism is the term used to describe going in to work even with a health problem. The phenomenon has been identified as one prior factor in sickness absence and, accordingly, the better it is understood, the better will be the prevention strategies. This study aimed to examine the mediating role of presenteeism (the ability to concentrate on work and to complete work despite a health problem) in the association between psychosocial factors at work and common mental disorders (CMD). This cross-sectional study included 1218 nursing personnel at a public hospital in Brazil. Structural equation modelling was performed. The sample comprised mostly women (85.4%), and the mean age was 44.1 (SD = 11.3; range: 24–70) years. Prevalence of presenteeism was 32.8%. Among presenteeist workers (n = 400), a relationship was observed between presenteeism and higher CMD scores. Furthermore, being able to concentrate on work even with a health problem mediated the relationship between social support and CMD and between psychological demands and CMD. Working when sick impairs both the work and the worker’s health. Interventions designed to improve working conditions and interpersonal relations can be effective strategies against presenteeism.
Analysis of Low Cancer Mortality Rates in the Wine Regions of Tokaj and Balaton in Hungary
Authors: Sipka Sándor , Nagy János , Sipka Péter , Kocsis Judit , Tóth Judit , Árkosy Péter , Horváth Zsolt
Published: September 2020

The age-adjusted death rates (AADRs) due to cancers were investigated in two historical regions of white wines (Tokaj and Balaton) and in Hódmezővásárhely (HMV) as a control territory in Hungary between 2000 and 2010 evaluating 111,910 persons. The results of AADRs due to the eight most frequent types/gastrointestinal cancers were as follows: Tokaj 2120/664, Balaton: 2417/824, HMV: 2770/821, nationwide: 2773/887. The values found in Tokaj and Balaton regions were significantly less than those of HMV and nationwide. However, the least values were found in Tokaj. This Tokaj-related strong difference was not found among the regions in the case of young populations with hematological diseases but only in the older people who have been consuming their wines for decades. Supposedly, this wine-specific anti-cancer phenomenon could be related to the chemical differences existing in the two types of white wines, namely, to the pro-oxidant molecules of Tokaj wines derived from Botrytis cinerea. The roles of red meat consumption, hardness of drinking water, mineral content of soil, and socioeconomic status were negligible. It should be stressed that these data are valid only for these populations, for this period. Noteworthily, the different types of wines may have different effects on mortality rates during long-lasting consumptions.
Assessing Productivity Development of Public Hospitals: A Case Study of Shanghai, China
Authors: Du Juan , Cui Shuhong , Gao Hong
Published: September 2020

As the main provider of medical services for the general public, the productivity changes of public hospitals directly reflect the development of the healthcare system and the implementation effect of medical reform policies. Using the dataset of 126 public hospitals in China from 2013 to 2018, this paper improves the existing literature in both index selection and model formulation, and examines public hospitals’ total factor productivity (TFP) growth. Empirical results not only demonstrate the trend of productivity development but also point out the directions in how to improve the current running status. Our study demonstrates that there were no obvious productivity fluctuations in public hospitals during the recent observing years, indicating that the performance of China’s public health system was generally acceptable in coping with fast-growing medical demand. However, the effect of public hospital reform has not been remarkably shown; thus, no significant productivity improvement was observed in most hospitals. Tertiary hospitals witnessed a slight declining trend in TFP, while secondary hospitals showed signs of rising TFP. To effectively enhance the overall performance of public hospitals in China, practical suggestions are proposed from the government and hospital levels to further promote the graded medical treatment system.
The Effects of Parental Absence on Children Development: Evidence from Left-Behind Children in China
Authors: Mao Mingzhi , Zang Lijun , Zhang Haifeng
Published: September 2020

Parental care in early childhood is viewed as one of the most important factors that help foster children’s abilities. Using two nationally representative datasets collected in China, this paper examines the effects of parental absence on the short-term in-school outcomes and long-term educational achievement of left-behind children. The results show that parental absence is negatively associated with the development of left-behind children. Left-behind children have a lower cognitive test score and academic test score, and they are also less likely to attend a college. In particular, a mother’s absence seems to have persistent negative effects on children’s development. Mechanism analyses show that parental absence may result in a less healthy mental status of children and reduce children’s efforts in class. However, we do not find significant evidence that the exposure to left-behind children in class lowers the in-school outcomes of children.
Does Mental Well-Being Protect against Self-Harm Thoughts and Behaviors during Adolescence? A Six-Month Prospective Investigation
Authors: Russell Kirsten , Rasmussen Susan , Hunter Simon C.
Published: September 2020

Mental well-being protects against the emergence of suicidal thoughts. However, it is not clear whether these findings extend to self-harm thoughts and behaviors irrespective of intent during adolescence—or why this relationship exists. The current study aimed to test predictions—informed by the integrated motivational–volitional (IMV) model of suicide—concerning the role of perceived defeat and entrapment within the link between mental well-being and self-harm risk. Young people (n = 573) from secondary schools across Scotland completed an anonymous self-report survey at two time points, six months apart, that assessed mental well-being, self-harm thoughts and behaviors, depressive symptomology and feelings of defeat and entrapment. Mental well-being was associated with reduced defeat and entrapment (internal and external) and a decrease in the likelihood that a young person would engage in self-harm thoughts and behaviors. The relationship between mental well-being and thoughts of self-harm was mediated by perceptions of defeat and entrapment (internal and external). Mental well-being was indirectly related to self-harm behaviors via decreased feelings of defeat and internal (but not external) entrapment. Taken together, these findings provide novel insights into the psychological processes linking mental well-being and self-harm risk and highlight the importance of incorporating the promotion of mental well-being within future prevention and early intervention efforts.
Frailty Status Typologies in Spanish Older Population: Associations with Successful Aging
Authors: Tomás José M. , Sentandreu-Mañó Trinidad , Fernández Irene
Published: September 2020

Background: Defining frailty typologies would contribute to guiding specific care interventions. These typologies could additionally be related to different health outcomes. This study aims at identifying subgroups of frail older adults based on the physical frailty phenotype and examining the relationships of these frailty profiles with quality of life and perceived health. Methods: This study relies on data from the SHARE project, namely a representative sample of 1765 Spanish-dwelling older adults identified as frail or pre-frail. Analysis included general descriptive statistics, exploratory latent class analysis (LCA) to determine the number of frailty subgroups, and LCA with covariates to examine differential relationships with markers of successful aging. Results: Statistical criteria and interpretability of the classes suggested that the LCA model with four classes should be retained. Class 1 was identified as the “frail people” group, Class 2 “activity problems” group, Class 3 “fatigued” group, and those belonging to Class 4 “lack of strength” group. Final LCA with covariates showed lower levels of quality of life and perceived health of the “frail” as compared to other frailty subgroups. Conclusion: This study revealed four different patterns of frailty attributes and further offered evidence on individuals’ differential status of health regarding distinct frailty conditions.
Lack of Association between the Reasons for and Time Spent Doing Physical Activity
Authors: Domínguez-Amorós Màrius , Aparicio-Chueca Pilar
Published: September 2020

Low levels of Physical Activity (PA) and sedentarism are associated with the onset of different pathologies and health problems. Regular physical activity has been linked with being beneficial to the health of the general population. Within this framework of analysis, the aim of the present study was to analyze the association between the time spent doing physical activity and the expressed motives for doing so, from which the innovative aspect of the paper emerges: the use of the time spent doing PA as a study variable of the phenomenon. The data analyzed come from the latest special Eurobarometer survey about the sport and physical activity done in Europe. Using an exploratory factorial analysis and a structural equations model, a six-dimensional factorial model was found that explains the reasons for doing PA, demonstrating that there is no relationship between the reasons for and time spent doing PA. The motivation is not a variable that explains the time spent doing PA, and another type of variable must be used to explain the phenomenon if PA is to be incentivized. Weaknesses of the study are that it works with individuals as a group and that the fundamental dependence on age is not introduced, which could determine interest in practicing PA. Similarly, the impact of the conditions of implementing PA, education, and family history should also be introduced into the model.
SEEP-CI: A Structured Economic Evaluation Process for Complex Health System Interventions
Authors: Madan Jason , Bruce Kumar Meghan , Taegtmeyer Miriam , Barasa Edwine , Singh Swaran Preet
Published: September 2020

The economic evaluation of health system interventions is challenging, and methods guidance on how to respond to these challenges is lacking. The REACHOUT consortium developed and evaluated complex interventions for community health program quality improvement in six countries in Africa and Asia. Reflecting on the challenges we faced in conducting an economic evaluation alongside REACHOUT, we developed a Structured Economic Evaluation Process for Complex Health System Interventions (SEEP-CI). The SEEP-CI aims to establish the threshold effect size that would justify investment in a complex intervention, and provide an assessment to a decision-maker of how likely it is that the intervention can achieve this impact. We illustrate how the SEEP-CI could have been applied to REACHOUT to identify outcomes where the intervention might have impact and causal mechanisms, through which that impact might occur, guide data collection by focusing on proximal outcomes most likely to illustrate the effectiveness of the intervention, identify the size of health gain required to justify investment in the intervention, and indicate the assumptions required to accept that such health gains are credible. Further research is required to determine the feasibility and acceptability of the SEEP-CI, and the contexts in which it could be used.
Effects of Toxic Metal Contamination in the Tri-State Mining District on the Ecological Community and Human Health: A Systematic Review
Authors: Park Hyejoon , Noh Keeyoon , Min Jihyun Jane , Rupar Christopher
Published: September 2020

Although extensive research exists on toxic environments in the Tri-State Mining District (TSMD), there has been a lack of research on how harmful effects in TSMD could affect residents living in those areas. However, quite recently, such research regarding relationships between the health conditions of residents and toxic elements in the TSMD began to grow. The increase of empirical studies means greater complexity of the findings that require a more intricate understanding. To meet the goals of this study, an extensive, systematic review of the literature using PRISMA was conducted. This method resulted in 19 articles that define the harmful effects of the TSMD on the ecology and the physical health of residents. This research found that toxic metals not only negatively impact natural processes in the TSMD environments (fish species reduction, kidney and liver problems, and toxic diet) but also continuously affect the health of residents (high blood Pb and mortality).This study makes a vital contribution building upon the existing outcomes of the correlations between toxic elements in the TSMD areas and the health of residents. Furthermore, conclusions of this study provide updated information to policymakers and health-related professionals by providing adequate and innovative remediations and health-related services in the TSMD.
Alternative and Experimental Therapies of Mycobacterium abscessus Infections
Authors: Meir Michal , Barkan Daniel
Published: September 2020

Mycobacterium abscessus is a non-tuberculous mycobacterium notoriously known for causing severe, chronic infections. Treatment of these infections is challenging due to either intrinsic or acquired resistance of M. abscessus to multiple antibiotics. Despite prolonged poly-antimicrobial therapy, treatment of M. abscessus infections often fails, leading to progressive morbidity and eventual mortality. Great research efforts are invested in finding new therapeutic options for M. abscessus. Clofazimine and rifabutin are known anti-mycobacterial antibiotics, repurposed for use against M. abscessus. Novel antimicrobials active against M. abscessus include delamanid, pretomanid and PIPD1 and the recently approved beta-lactamase inhibitors avibactam, relebactam and vaborbactam. Previously unused antimicrobial combinations, e.g. vancomycin–clarithromycin and dual beta-lactam therapy, have been shown to have synergistic effect against M. abscessus in experimental models, suggesting their possible use in multiple-drug regimens. Finally, engineered phage therapy has been reported to be clinically successful in a severe case of disseminated M. abscessus infection. While many of these experimental therapeutics have shown activity against M. abscessus in vitro, as well as in intracellular and/or animal models, most have little if any evidence of effect in human infections. Clinical studies of M. abscesssus treatments are needed to reliably determine the value of their incorporation in therapeutic regimens.
High-Temperature-Responsive Poplar lncRNAs Modulate Target Gene Expression via RNA Interference and Act as RNA Scaffolds to Enhance Heat Tolerance
Authors: Song Yuepeng , Chen Panfei , Liu Peng , Bu Chenhao , Zhang Deqiang
Published: September 2020

High-temperature stress is a threat to plant development and survival. Long noncoding RNAs (lncRNAs) participate in plant stress responses, but their functions in the complex stress response network remain unknown. Poplar contributes to terrestrial ecological stability. In this study, we identified 204 high-temperature-responsive lncRNAs in an abiotic stress-tolerant poplar (Populus simonii) species using strand-specific RNA sequencing (ssRNA-seq). Mimicking overexpressed and repressed candidate lncRNAs in poplar was used to illuminate their regulation pattern on targets using nano sheet mediation. These lncRNAs were predicted to target 185 genes, of which 100 were cis genes and 119 were trans genes. Gene Ontology enrichment analysis showed that anatomical structure morphogenesis and response to stress and signaling were significantly enriched. Among heat-responsive LncRNAs, TCONS_00202587 binds to upstream sequences via its secondary structure and interferes with target gene transcription. TCONS_00260893 enhances calcium influx in response to high-temperature treatment by interfering with a specific variant/isoform of the target gene. Heterogeneous expression of these two lncRNA targets promoted photosynthetic protection and recovery, inhibited membrane peroxidation, and suppressed DNA damage in Arabidopsis under heat stress. These results showed that lncRNAs can regulate their target genes by acting as potential RNA scaffolds or through the RNA interference pathway.