bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of the Covid-19 Free Operation Path Protocol on the Incidence of Lung Complications in Postoperative Elective Patients at dr. Moewardi Hospital Surakarta
Authors: Aktama Galih , Hengky Agung Nugroho  , Muhammad David Perdana Putra
Published: June 2021

The pandemic that began in late 2019, COVID-19, affects all patients, including cancer patients. Patients with cancer that continues to spread and  there is no other effective alternative treatment must undergo surgery so that cancer does not get worse. Given this problem, many health care centers have developed a protocol system in the form of a COVID-19-free surgical route. This study is a retrospective cohort study comparing the incidence of pulmonary complications in patients undergoing elective cancer surgery at dr. Moewardi Surakarta before and during the COVID-19 pandemic. The study sample was adult patients  aged ≥ 18 years which underwent elective surgical procedures with the aim of curative cancer starting before COVID-19 (March 2019-February 2020) until the time the COVID-19 pandemic emerged (March 2020 - February 2021). The data obtained were 768 patients. Of these patients, 384 were classified as having a COVID19-free operation route during the pandemic, and 384 others underwent elective surgery in the pre-pandemic period. Based on the Chi-Square test, a p-value of 0.850 was obtained (P>0.05) which shows that there is significant difference between cases of pulmonary complications in surgical patients before and after the pandemic who were carried out through the COVID-19-free protocol route. In conclusion, there is no significant change in effect of the covid-19 free operation path protocol on the incidence of lung complications in postoperative elective patients at dr. Moewardi Hospital Surakarta, although this patented and mandatory protocol can reduce cancer patients’ morbidity and mortality who undergoing elective surgery during a pandemic.
Correlation Between Candidiasis And Mortality In Gastric Ulcer Perforation Patients
Authors: Sulistiyani Faradina , Vicky Sumarki Budipramana  , Pepy Dwi Endraswari
Published: June 2021

Background: Gastric ulcer disease remains the most common gastrointestinal disease. This affects about 4 million people every year worldwide with an incidence of 1.5%-3% and 2-14% of these will progress to perforation. Mortality is reported in 30% of cases and caused morbidity in 50% of patients. Some studies have suggested that mortality in patients with peritonitis accompanied by candidiasis ranges from 20%-75%, whereas others have argued that the presence of fungal isolates in patients with perforated peptic ulcer does not affect the outcome. A recent study reported an incidence of 45% of patients peptic ulcer perforation cases accompanied by candidiasis in Dr. Soetomo General Hospital Surabaya in 2019.Methods: This was a cross sectional study based on medical record data of patients with gastric ulcer perforation accompanied by candidiasis who underwent laparotomy and gastric repair surgery at Dr. Soetomo General Hospital Surabaya from January 2019 to December 2020.Results: There was no significant correlation between candidiasis and mortality in gastric ulcer perforation patients (p=0.989).Conclusion: Candidiasis does not increase mortality in patients with gastric ulcer perforation.
Günahlarımız İçin Başkasını Suçlamanın Dayanılmaz Hafifliği (Günah Keçisi)
Authors: ÇELIK Ali Ruhan
Published: June 2021

In some of the rituals that are encountered in history, goats are symbolized as the image of people's sins and were sent out from their habitat by ceremonies or slaughtered. On the other hand, according to psychological science which anaylzes spiritual processes of human beings and animals, it may be necessary for individuals to direct the evil to any living being or an object to not to face with painful effects of negative energy that is formed as a result of blocking. Because the negative energy, exists in our personality, creats enxiety for an individual. Therefore, the individual can look for outlets to get rid of this pressure and not to experience its negative psychological effects. For instance, it is also known as detention and agression hypothesis, the "Scapegoat". In addition to that the term "Witch Hunt" is used frquently. Accordingly, in this study, the "witch hunt" that happened in medieval times and known as one of the biggest wildnesses throughout history will be analysed. It is desired to narrate positioning women instead of goats, the rituals carried out and the psycho-social dynamics of the period. Also, examples of scapegoating and demonizing the enemy in recent political developments are presented.
Sanal Market Alışveriş Deneyiminde Müşteri Tatmini ve Davranışsal Sonuçların Belirlenmesi Üzerine Bir Araştırma
Authors: Eren Berrin Arzu
Published: June 2021

Customer experience forms the basis for customers to develop positive attitudes and behaviors towards the business. The virtual market shopping experience is also an important part of the online customer experience today. Customer experience continues to be an important factor in determining both consumer behavior and spending habits, along with the changing needs and expectations of consumers during the pandemic process. At this point, the study aims to reveal the virtual market shopping experience of consumers within the scope of the factors that affect this experience and to determine the effect of the virtual market shopping experience on customer satisfaction. In addition, within the scope of the study, it is aimed to reveal the effect of customer satisfaction on repetitive purchasing and word-of-mouth communication behaviors for online market shopping. For these purposes, the data collected from 417 participants using the online questionnaire with a convenience sampling method Structural Equation Modelling was applied to the data. While the findings of the study reveal the effect of the brand experience dimension of the virtual grocery shopping experience on the total shopping experience, they also point to the positive effect of the total shopping experience on customer satisfaction. In addition, the study findings show that customer satisfaction regarding virtual market shopping has a positive effect on customers' repetitive purchasing intention and word-of-mouth behavior.
Büyük Dönüşüm: Çağımızın Siyasal ve Ekonomik Kökenleri, Karl Polanyi, 1944 (Çev. Ayşe Buğra, 2020)
Authors: Koçoğlu Eyiler Safura
Published: June 2021

Kapitalizmin büyük mağduriyetler yarattığı ve insan psikolojisini yıprattığı, fakat yine de insan doğası ile uyumlu başka alternatiflerinin kapitalizm kadar yaygın olmadığı günümüzde insan, bu sistemin içerisinde kalmaya devam ederek olumsuzluklarından kendini koruma yolları aramaktadır. Günümüz insanının en büyük derdi, kuşkusuz böyle bir sistemde günü kurtarmak olmuştur çünkü yarın, bu insan için sadece spekülasyon ve manipülasyondan ibaret meçhule uzanan karanlık bir yol niteliğindedir. Günümüzde COVID-19 pandemisi, bu belirsizliğe yenilerini eklemiş ve sistemin daha insan odaklı politikalar üretmesi gerekliliğini gözler önüne sermiştir. Bu süreçte insanın, yaşatmadan yaşayamayacağı su götürmez bir gerçek olarak karşısında durmaktadır. İnsan, yeni bir büyük dönüşümün eşiğinde midir? Ya kapitalizm daha insan odaklı bir hale getirilecek ya da daha vahşi bir kapitalizm hayatlarımızın gerçeği konumuna gelecektir.
Mi escape
Authors: Salmerón Natalie
Published: June 2021

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De vuelta
Authors: Crowley John , Durán-Fuentes Brian
Published: June 2021

It is a true honor for me to introduce a work by John Crowley to Spanish readers for the very first time. From the moment I was given the opportunity to translate an unpublished piece for this journal, I knew I had to translate a story by Mr. Crowley. I was very fortunate to have him accept my request, and I for that I will always be thankful. John Crowley is a young but incredibly promising author, whose graceful prose displays his roots as a native son of Arlington, and as such he is more than able to give a voice to the spirit of the city. Therefore, I was tasked with channeling all of this into my native language. It wasn't a simple endeavor, but I'm pleased to provide this translation, which hopes to resonate with the community from which it came, and beyond.Brian Durán-Fuentes
José Angel Gutiérrez: Professor, Politician, and Political Activist
Authors: Thomas Nathalie
Published: June 2021

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De la ciencia a la poesía en el mismo viaje: entrevista a Balam Rodrigo
Authors: Aguilar Manjarrez Flor
Published: June 2021

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La perpetuación de la Revolución de 1910
Authors: Cox Britney
Published: June 2021

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Elena Poniatowska y Sor Juana
Authors: Gurrola Heather
Published: June 2021

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Toda literatura es histórica: Dr. Oswaldo Estrada
Authors: Ruelas Paulina , Estrada Oswaldo
Published: June 2021

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An Econometric Analysis of the Effects of the Job Training Partnership Act on Self-Sufficiency
Authors: N. Zumaeta Jorge
Published: June 2021

The primary purpose of the study is to investigate the likelihood of a Job Training Partnership Act (JTPA) participant getting a job placement after receiving training, and to identifying the factors that affect the attainment of self-sufficiency (Bloom and Charles, 2001; Friedlander, 1988; Gueron and Edward, 1991). Additionally, the research study focuses on learning more about the determinants of the wage rate at the time when a participant gets a placement.
This study has found that successful completion of training combined with prior work experience are the most important factors that affect the chance of getting a job placement. This finding is consistent with Eberts (2002) and Schexnayder et al. (1991). Furthermore, the results show that the most significant variables affecting self-sufficiency are (1) completion of long-term training and (2) reading ability. An additional finding of the study is that if the participant is a recipient of food stamps, then his/her probability of achieving self-sufficiency decreases. Our study’s main contribution is the identification of significant variables to be included in the development of workforce policies aiming at promoting economic self-sufficiency and mitigating poverty in Florida.
GENDER BASED ANALYSIS ON ACTIVITIES OF Parkia biglobosa (Jacq) G. Don AND Vitelleria paradoxa (C. F. Gaertn) VALUE CHAINS IN DERIVED SAVANNAH ZONE OF NIGERIA
Authors: Olayemi O. T. , Lawal K. J. , Salami K. D. , Oyerinde O. V.
Published: June 2021

The research examined the gender based activities on Parkia biglobosa and Vitelleria paradoxa value chains in derived savannah zone of Nigeria using Oyo State as a case study. The research survey design was adopted which involved administration of semi-structured questionnaires of one hundred and twenty (120) respondents in two Local Government areas of Oyo State namely: Atisbo and Saki. The study areas were purposively selected based on the abundance of the selected Non Timber Forest Products (NTFPs). The data were analysed using descriptive statistic. The result showed that farm had the highest number of seeds for collection (48.3% and 41.7%) of Parkia biglobosa and Vitelleria paradoxa followed by community forests. Greater percentage of the population of Shea butter and Parkia producers in the study area were dominated by aged group which were mostly women. Produce were mainly for local consumption while a few numbers attract the larger domestic and international markets. Therefore, it is recommended that government should help in providing simple, easy technology that will facilitate good hygiene practices, packaging and also provide basic infrastructures like boreholes, sorting, cracking, dehuller and milling machines for both the fruits and seeds processors
Genomic Analysis of the Mycoparasite Pestalotiopsis sp. PG52
Authors: ZHANG DENGYUN , YU JINDE , MA CHANGLE , KONG LEI , HE CHENGZHONG , LI JING
Published: June 2021

Pestalotiopsis sp. is a mycoparasite of the plant pathogen Aecidium wenshanense. To further understand the mycoparasitism mechanism of Pestalotiopsis sp., we assembled and analyzed its genome. The genome of Pestalotiopsis sp. strain PG52 was assembled into 335 scaffolds and had a size of 58.01 Mb. A total of 20,023 predicted genes and proteins were annotated. This study compared PG52 with the mycoparasites Trichoderma harzianum, Trichoderma atroviride, and Trichoderma virens. This study reveals the entirely different mycoparasitism mechanism of Pestalotiopsis compared to Trichoderma and reveals this mycoparasite’s strong ability to produce secondary metabolites.
Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry for Identification of Microorganisms in Clinical Urine Specimens after Two Pretreatments
Authors: LEI DERU , CHEN PEIYING , CHEN XUETING , ZONG YUJIE , LI XIANGYANG
Published: June 2021

Rapid identification of microorganisms in urine is essential for patients with urinary tract infections (UTIs). Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been proposed as a method for the direct identification of urinary pathogens. Our purpose was to compare centrifugation-based MALDI-TOF MS and short-term culture combined with MALDI-TOF MS for the direct identification of pathogens in urine specimens. We collected 965 urine specimens from patients with suspected UTIs, 211/965 isolates were identified as positive by conventional urine culture. Compared with the conventional method, the results of centrifugation-based MALDI-TOF MS were consistent in 159/211 cases (75.4%), of which 135/159 (84.9%) had scores ≥ 2.00; 182/211 cases (86.3%) were detected using short-term culture combined with MALDI-TOF MS, of which 153/182 (84.1%) had scores ≥ 2.00. There were no apparent differences among the three methods (p = 0.135). MALDI-TOF MS appears to accelerate the microbial identification speed in urine and saves at least 24 to 48 hours compared with the routine urine culture. Centrifugation-based MALDI-TOF MS is characterized by faster identification speed; however, it is substantially affected by the number of bacterial colonies. In contrast, short-term culture combined with MALDI-TOF MS has a higher detection rate but a relatively slow identification speed. Combining these characteristics, the two methods may be effective and reliable alternatives to traditional urine culture.
Dynamiczna koncepcja przewag komparatywnych
Authors: Sopoćko Andrzej
Published: June 2021

Zróżnicowanie poziomu rozwoju poszczególnych krajów nie da uzasadnić się lepszymi warunkami przyrodniczymi. Tzw. rajskie wyspy nie są jego liderami, natomiast szereg krajów o trudnych warunkach przyrodniczych (Skandynawia, Japonia) należą do czołówki cywilizacyjnej świata. Jak się jednak okazuje, implementacja wybranych stamtąd rozwiązań przynosi ograniczone sukcesy. Historycznie jest to nowa sytuacja. Produkcja taśmowa z fabryk Forda dała się zastosować efektywnie na całym świecie, podobnie sieci fast-food czy kontenery w transporcie. Obecnie jednak trudno znaleźć tak spektakularne przykłady. Może to zaskakiwać, ponieważ istnieją dalej znaczące różnice w efektywności gospodarek poszczególnych krajów. W Europie nie zmniejsza się dystans Północ – Południe, Stany Zjednoczone od Meksyku dzieli pod tym względem przepaść. A przecież, poza nielicznymi wyjątkami, prawie wszystkie gospodarki są obecnie otwarte na dobra jakim są sprawdzone rozwiązania. Jeśli nawet całości nie można szybko przekształcić według najlepszych wzorów, to powinno uzyskać się postęp stopniowo, adaptując poszczególne elementy danej gospodarki na kształt najlepszych rozwiązań np. u sąsiadów. W ten sposób dystans rozwojowy powoli ulegałby zmniejszeniu, przynajmniej nie powiększał się. Ta metoda jednak nie przynosi znaczących rezultatów. Powodem wydaje się być coraz większa integracja i złożoność krajowych systemów wytwarzania. Daje się to dostrzec przede wszystkim przy próbach adaptacji zagranicznych systemów proinnowacyjnych. Czy wobec tego taka implementacja jest w ogóle niemożliwa? Otóż nie. Co prawda nieskuteczne jest odgórne adaptowanie otoczenia, ale może się udać uruchomienie procesu samoadaptacji, idącego w głąb całego systemu. Ale jest to operacja trudna, wymagająca nietradycyjnego (niestatycznego) podejścia systemowego.
Chalmers, Beverley. Birth, Sex and Abuse: Women’s Voices Under Nazi Rule. Tolworth, Surrey, UK: Grosvenor House Publishing Ltd, 2015.
Authors: Malerk Tamala
Published: June 2021

Review of Chalmers, Beverley. Birth, Sex and Abuse: Women’s Voices Under Nazi Rule.Tolworth, Surrey, UK: Grosvenor House Publishing Ltd, 2015.
Strutin, Michal. Judging Noa: A Fight for Women’s Rights in the Turmoil of the Exodus. Fairfield, CA: Bedazzled Ink Publishing Company, 2018.
Authors: Vinokor-Meinrath Samantha
Published: June 2021

Review of Strutin, Michal. Judging Noa: A Fight for Women’s Rights in the Turmoil of the Exodus. Fairfield, CA: Bedazzled Ink Publishing Company, 2018.
Whitewashing Narratives: Israeli Media and the Framing of the Kidnapped Yemenite Babies Affair
Authors: Madmoni-Gerber Shoshana
Published: June 2021

This essay offers a review of ongoing media analysis of the kidnapped Yemenite Babies Affair in light of recent changes in public awareness since the emergence of social media and the more recent formal governmental recognition. It argues that the government’s efforts to silence this affair over decades would not have been possible without the media’s full cooperation. Moreover, the public denial of this affair contributes to the ongoing intra-Jewish rift and racism in Israeli society today. Questions regarding the reconciliation and remembrance of this affair in the public sphere will strongly influence the identity formation of Yemenite and Mizrahi children of future generations.
Effects of Different Soil Conditioners on Water Use Efficiency and Tomato Plant Growth in Loam and Clay Loam Soils
Authors: İŞLER Nurten , KAVDIR Yasemin
Published: June 2021

A pot experiment was conducted applying 8% olive pomace compost, 4% perlite and 0.12% hydrophilic polymers on loam and clay loam soils with three replications. Tomato (Lycopersicon lycopersicum L.) seedlings were transferred to each pot and plants were grown under controlled atmosphere conditions. Effects of different soil conditioners on plant water use efficiency and tomato plant growth was determined. As a result, olive pomace compost applications to loam soil saved irrigation water 45.12%, 42.99% and 38.88% compared to control, perlite and hydrophilic polymers treatments respectively. On the other hand, hydrophilic polymers treatments saved irrigation water 17.82%, 46.76% and 27.29% compared to control, perlite and olive pomace compost treatments respectively for clay loam soil. Soil pH decreased and electrical conductivity (EC) increased for both soils after the experiment. The highest soil EC value was dedected with the application of olive pomace compost. Perlite application increased plant fresh weight and length while olive pomace compost increased branch numbers of tomato for clay loam soil. Root length and surface areas were maximum under olive pomace compost applications for both soils.
Сучасні технології в науці та освіті
Authors:   Східноукраїнський національний університет імені Володимира Даля, Целіщев Олексій , Татарченко Галина ,   Східноукраїнський національний університет імені Володимира Даля, Хорошун Ганна ,   Східноукраїнський національний університет імені Володимира Даля
Published: June 2021

У колективній монографії представлені матеріали IV Міжнародної науково-практичної конференції «Сучасні технології в науці та освіті», яка проходила 22-23 квітня 2021 р. в м. Сєвєродонецьк. Представлено результати актуальних досліджень за напрямами: Інновації у будівництві та архітектурі; Комп’ютерні науки, інженерія та кібербезпека; Проблеми розвитку транспорту та логістики, Сучасні проблеми матеріалознавства, фізики, електричної інженерії; Сучасні тенденції вищої освіти в умовах глобалізації; Сучасні проблеми машинобудування, хімічної інженерії, екології та екологічної безпеки. Матеріали колективної монографії можуть бути використані викладачами і науковцями вищих навчальних закладів, науково-технічними працівниками, аспірантами та студентами. Матеріали друкуються мовою оригіналу.
Software package for calculation of fertilizer mixture component doses
Authors:   Institute for Technical Support of Agriculture, branch of VIM, Mitrofanov S.V. , Pekhnov A.S. ,   Institute for Technical Support of Agriculture, branch of VIM, Blagov D.A. ,   Institute for Technical Support of Agriculture, branch of VIM
Published: June 2021

A methodology and a software package for calculating the fertilizer mixture component doses depending on the data on the variability of agrochemical indicators and agricultural crops planned for cultivation are discussed. The software package can be used by both agricultural enterprises and fertilizer manufacturers with fertilizer mixing plants for the production of fertilizer mixtures for the soil, climatic and economic conditions of the end consumer.
Development of a Mobile Integrated System for Thermal Imaging Videodigital Diagnostics of Cow Diseases
Authors:   VIM, Tsoi Yu.A. , Lyubimov V.E. ,   VIM, Saginov L.D. ,   VIM, Kirsanov V.V. ,   VIM, Golovkin M.E. ,   VIM, Mishurov N.P. ,   Rosinformagrotekh
Published: June 2021

The principles of creating a mobile integrated system for thermal imaging video-digital diagnostics of cow diseases, a block diagram of a mobile integrated system and a sequence of operations are described. The parameters of thermal imaging equipment for detecting temperature anomalies have been determined. Methods of segmentation of thermal images, histogram analysis and new methods of phase portrait analysis are selected. The features of the formation and processing of thermal images for monitoring inflammatory processes in animals have been determined.
Results of researching the process of treatment of cattle manure in a vortex layer apparatus
Authors:   Institute of Livestock Mechanization, a branch of VIM, Gridnev P.I. , Gridneva T.T. ,   Institute of Livestock Mechanization, a branch of VIM
Published: June 2021

The results of studies of the of cattle manure treatment in the vortex layer apparatus are presented. It has been found that these devices can treat manure having a moisture content of more than 93% and a particle content of maximum 7 mm in size. With an increase in the moisture content of manure from 93% to 96%, the energy intensity of the dispersion process decreases from 0.7 kWh / t to 0.53 kWh / t, the productivity increases to 22 t / h, and the weight of ferromagnetic elements loaded into the apparatus should be in the range of 285 g to 400 g.
Influence of marsh island size on nekton communities: intermediate optima rather than Single-Large-or-Several-Small (SLOSS)
Authors: Ziegler SL , Clance LR , McMains AR , Miller MD , Fodrie FJ
Published: June 2021

Habitat extent and configuration are critical drivers of faunal abundance, diversity, and ecosystem functioning. Evidence from terrestrial systems often suggests that large contiguous tracts of habitat generally support more species and individuals than several small patches of equal summed area. However, studies from shallow-water marine systems often suggest the opposite trend or that there are more complex interactions. Since tidal wetlands (e.g. salt marshes and mangrove forests) are at the interface between terrestrial and marine ecosystems and provide essential nursery habitat for a variety of estuarine taxa, it is important to elucidate how the size, configuration, and surrounding matrix of these wetlands influence their role in supporting faunal communities. We sampled 12 isolated marsh islands ranging in size from 300 to 55000 m2 within North Carolina, USA, to better understand the influence of marsh size and configuration on overall biodiversity and faunal abundance of estuarine nekton. Field observations indicated that nekton catch rates were directly correlated with marsh area and perimeter; however, species richness did not change with marsh size or configuration. Further analysis indicated that small and medium marsh islands support higher species turnover among islands than large marsh islands. Quantitative simulations using the ‘Single-Large-Or-Several-Small’ framework and idealized, circular islands showed that intermediate-sized islands support the highest relative abundance of nekton after standardizing for total marsh area. Our findings suggest that focused conservation or restoration efforts for marsh islands ranging in size from 1000 to 10000 m2 may help maintain and enhance estuarine nekton communities.
Atomistic Study on the Mechanical Behavior of Silicon-Base Nanotubes
Authors: Singh Prabhjot Singh , Chahal Iqbal Singh
Published: June 2021

Recently, silicon nanotubes (SiNTs) have been successfully synthesized and have attracted many researchers to work on the different aspects of them. In the present study, the stress-strain curve along with the Young’s modulus as a significant mechanical property of single walled silicon nanotubes at different diameters are determined. The simulation is performed by the use of molecular dynamics based on the Tersoff-Brenner many-body potential energy function. The results of the total strain energy of nanotubes as an accurate and effective methodology are used to establish appropriate expressions for evaluating Young’s modulus of the nanotubes.
Pemilihan Metode dan Algoritma dalam Analisis Sentimen di Media Sosial : Sistematic Literature Review
Authors: Singgalen Yerik Afrianto
Published: June 2021

This article use Systematic Literature Review (SLR) to classify sentiment analysis based on case studies, methods, social media, and platforms. The coding stage is divided into three stages, namely the open, selective and axial coding. The literature study on sentiment analysis is divided into two parts: identifying gaps based on case studies and data sources and identifying gaps based on the methods or algorithms used. The gap identification results based on case studies and data sources show that popular review topics are synonymous with entertainment, economic and political content. Therefore, the quantity of research with review topics related to the implementation of education, the dynamics of the bureaucracy, health facilities and services, and non-governmental organization’s activities need to be increased. Meanwhile, the most dominant platforms used as data sources are website and mobile-based applications. The results of the gap identification based on the method and algorithm show that the quantity of research with the Naive Bayes Classifier (NBC) and Support Vector Machine (SVM) method or algorithm is more dominant than the k-Nearest Neighbor (k-NN) and Lexicon-based. Thus, it is necessary to increase the number of other classification methods such as Particle Swarm Optimization, BM25, Decision Tree, K-Means, and Neural Networks.
The Role of Information Systems Capabilities in Enhancing the Organizational Performance
Authors: Tashtoush Laith
Published: June 2021

The literature supports that information systems improve the effective performance of any organization and gain a competitive advantage for their success in the business environment. Therefore, the scholars should do more studies that focus on how to enhance organizational performance to let corporations to sustain their competitive advantage. This study aims to empirically investigate the mediating role of competitive advantage with information systems capabilities and organizational performance among managers and department heads working in Jordanian industrial corporations. The study population consisted of all managers and department heads working in 20 Jordanian industrial corporations. The analysis of the data included the calculation of descriptive statistics as well as structural equation modeling, regression analysis, correlation analysis, and factor analysis. The study results showed that information systems capabilities, competitive advantage, and organizational performance were statistically significant. In addition, the result revealed that information system capabilities through competitive advantage influence organizational performance. The study model developed to provide the relationships of information systems capabilities through competitive advantage that can be used by Jordanian industrial corporations as evidence of a positive impact on organizational performance of managers and heads of departments in their corporations.
Giresun ve İlçelerinde Yetiştirilen Yerel Erik Çeşitlerinin Pomolojik ve Morfolojik Özeliklerinin Belirlenmesi
Authors: ÖNCÜL Canan , AYGÜN Ahmet
Published: June 2021

Bu araştırma Giresun ili Merkez, Bulancak, Keşap İlçelerinde 2016-2017 yılları arasında yürütülmüştür. Çalışma yapılan alanda 20 farklı isimde anılan yerel erik çeşidi belirlenmiştir. Belirlenen erik çeşitlerinin ağaç özellikleri ve meyve özellikleri tespit edilmiştir. Belirlenen yerel erik çeşitlerinin ortalama meyve ağırlığı 8.02-169.40 g, meyve eni 20.65-42.06 mm, meyve boyu 25.42-42.89 mm, meyve yüksekliği 23.33-43.67 mm, meyve sapı uzunluğu 11.63-17.64 mm, meyve sapı çapı 0.80-2.53 mm, çekirdek ağırlığı 0.31-1.61 g, titre edilebilir asitlik %1.15-2.83, pH 2.13-3.83, suda çözünebilir kuru madde miktarının %7.12-18.47 olarak değişim gösterdiği tespit edilmiştir. Erik çeşitlerinde tomurcuk kabarması 25 Ocak-18 Mart tarihleri arasında, tomurcuk patlaması 8 Şubat-23 Mart tarihleri arasında, İlk çiçeklenme 20 Şubat-27 Mart tarihleri arasında, tam çiçeklenme 1 Mart ile 9 Nisan tarihleri arasında, çiçeklenme sonu 10 Mart-20 Nisan tarihleri arasında gerçekleşmiştir. Eriklerin hasat tarihleri ise 18 Haziran-31 Ağustos tarihleri arasında 75 günlük bir periyotta dağılım göstermiştir. Yaprak döküm tarihi Ekim ayının 4. haftası ile Aralık ayının 3. haftası arasında olduğu gözlenmiştir. Sonuç olarak, yörede farklı bir çeşit zenginliği tespit edilmiştir.
Developmental Perspectives on Arterial Fate Specification
Authors: Chen Dongying , Schwartz Martin A. , Simons Michael
Published: June 2021

Blood vessel acquisition of arterial or venous fate is an adaptive phenomenon in response to increasing blood circulation during vascular morphogenesis. The past two decades of effort in this field led to development of a widely accepted paradigm of molecular regulators centering on VEGF and Notch signaling. More recent findings focused on shear stress-induced cell cycle arrest as a prerequisite for arterial specification substantially modify this traditional understanding. This review aims to summarize key molecular mechanisms that work in concert to drive the acquisition of arterial fate in two distinct developmental settings of vascular morphogenesis:de novovasculogenesis of the dorsal aorta and postnatal retinal angiogenesis. We will also discuss the questions and conceptual controversies that potentially point to novel directions of investigation and possible clinical relevance.
Controllable Synthesis of 2D Nonlayered Cr2S3 Nanosheets and Their Electrocatalytic Activity Toward Oxygen Evolution Reaction
Authors: Shifa Tofik Ahmed , Mazzaro Raffaello , Morandi Vittorio , Vomiero Alberto
Published: June 2021

The design of oxygen evolution reaction (OER) electrocatalysts based on Earth-abundant materials holds great promise for realizing practically viable water-splitting systems. In this regard, two-dimensional (2D) nonlayered materials have received considerable attention in recent years owing to their intrinsic dangling bonds which give rise to the exposure of unsaturated active sites. In this work, we solved the synthesis challenge in the development of a 2D nonlayered Cr2S3 catalyst for OER application via introducing a controllable chemical vapor deposition scheme. The as-obtained catalyst exhibits a very good OER activity requiring overpotentials of only 230 mV and 300 mV to deliver current densities of 10 mA cm−2 and 30 mA cm−2, respectively, with robust stability. This study provides a general approach to optimize the controllable growth of 2D nonlayered material and opens up a fertile ground for studying the various strategies to enhance the water splitting reactions.
Membrane Insertion of MoS2 Nanosheets: Fresh vs. Aged
Authors: Ye Rui , Song Wei , Ou Xinwen , Gu Zonglin , Zhang Dong
Published: June 2021

Fresh two-dimensional molybdenum disulfide (MoS2) absorbs the hydrocarbon contaminations in the ambient air and makes surface aging. To understand how the surface aging influences the interactions between MoS2 and biomolecules is important in the biomedical applications. Here, employing all-atom molecular dynamics simulations, we investigated the interactions of the fresh and aged MoS2 nanosheets with the lipid membranes of different components. Our results demonstrate that both the fresh and aged MoS2 nanosheets can spontaneously insert into the bilayer membranes. However, the fresh MoS2 nanosheet displays significantly stronger interaction and then has a larger penetration depth than the aged counterpart, regardless of the lipid components. The calculations of potential mean forces through the umbrella sampling further confirm that the insertion of fresh MoS2 into the lipid membranes is more energetically favorable. Moreover, we found that the fresh MoS2 nanosheet can cause a larger damage to the integrity of lipid membranes than the aged one. This work provides insightful understandings of the surface-aging-dependent interactions of the MoS2 nanosheets with biomembranes, which could facilitate the design of novel MoS2-based nanodevices with advanced surface properties.
Accessing Artificial Intelligence for Clinical Decision-Making
Authors: Giordano Chris , Brennan Meghan , Mohamed Basma , Rashidi Parisa , Modave François , Tighe Patrick
Published: June 2021

Advancements in computing and data from the near universal acceptance and implementation of electronic health records has been formative for the growth of personalized, automated, and immediate patient care models that were not previously possible. Artificial intelligence (AI) and its subfields of machine learning, reinforcement learning, and deep learning are well-suited to deal with such data. The authors in this paper review current applications of AI in clinical medicine and discuss the most likely future contributions that AI will provide to the healthcare industry. For instance, in response to the need to risk stratify patients, appropriately cultivated and curated data can assist decision-makers in stratifying preoperative patients into risk categories, as well as categorizing the severity of ailments and health for non-operative patients admitted to hospitals. Previous overt, traditional vital signs and laboratory values that are used to signal alarms for an acutely decompensating patient may be replaced by continuously monitoring and updating AI tools that can pick up early imperceptible patterns predicting subtle health deterioration. Furthermore, AI may help overcome challenges with multiple outcome optimization limitations or sequential decision-making protocols that limit individualized patient care. Despite these tremendously helpful advancements, the data sets that AI models train on and develop have the potential for misapplication and thereby create concerns for application bias. Subsequently, the mechanisms governing this disruptive innovation must be understood by clinical decision-makers to prevent unnecessary harm. This need will force physicians to change their educational infrastructure to facilitate understanding AI platforms, modeling, and limitations to best acclimate practice in the age of AI. By performing a thorough narrative review, this paper examines these specific AI applications, limitations, and requisites while reviewing a few examples of major data sets that are being cultivated and curated in the US.
Examining the Efficacy of Fishbowl Simulation in Preparing to Teach English Learners in Secondary Schools
Authors: Liu Kimy , McFarland Jon
Published: June 2021

During the COVID-19 crisis, teacher educators grappled to provide teacher candidates meaningful field experiences to serve English learners (ELs) during campus closures. The purpose of this study was to explore teacher candidates’ (TCs) beliefs on second language acquisition (SLA) in the context of teaching ELs in secondary schools. Multiple data sources were used to evaluate fishbowl simulations’ efficacy as a viable alternative to gain meaningful field experience. Findings suggest strong connections between participants’ beliefs and their chosen instructional moves, with participants realizing the importance of meaning-making. Teacher candidates and teacher educators gain unique insight on effectively teaching and implementing SLA strategies with fishbowl simulations.
Non-invasive Beta-cell Imaging: Visualization, Quantification, and Beyond
Authors: Murakami Takaaki , Fujimoto Hiroyuki , Inagaki Nobuya
Published: June 2021

Pancreatic beta (β)-cell dysfunction and reduced mass play a central role in the development and progression of diabetes mellitus. Conventional histological β-cell mass (BCM) analysis is invasive and limited to cross-sectional observations in a restricted sampling area. However, the non-invasive evaluation of BCM remains elusive, and practical in vivo and clinical techniques for β-cell-specific imaging are yet to be established. The lack of such techniques hampers a deeper understanding of the pathophysiological role of BCM in diabetes, the implementation of personalized BCM-based diabetes management, and the development of antidiabetic therapies targeting BCM preservation and restoration. Nuclear medical techniques have recently triggered a major leap in this field. In particular, radioisotope-labeled probes using exendin peptides that include glucagon-like peptide-1 receptor (GLP-1R) agonist and antagonist have been employed in positron emission tomography and single-photon emission computed tomography. These probes have demonstrated high specificity to β cells and provide clear images accurately showing uptake in the pancreas and transplanted islets in preclinical in vivo and clinical studies. One of these probes, 111indium-labeled exendin-4 derivative ([Lys12(111In-BnDTPA-Ahx)]exendin-4), has captured the longitudinal changes in BCM during the development and progression of diabetes and under antidiabetic therapies in various mouse models of type 1 and type 2 diabetes mellitus. GLP-1R-targeted imaging is therefore a promising tool for non-invasive BCM evaluation. This review focuses on recent advances in non-invasive in vivo β-cell imaging for BCM evaluation in the field of diabetes; in particular, the exendin-based GLP-1R-targeted nuclear medicine techniques.
Effect of Rolling Deformation on Creep Properties of FeCrAl Alloys
Authors: Lai Huan Sheng , Guo Jingyu , Zhang Shanglin , Yu Xiaobin , Meng Fanqiang , Zhao Zilong , Zhou Wenzhong
Published: June 2021

FeCrAl alloy is one of the most promising nuclear fuel claddings among many accident tolerant fuel (ATF) materials due to its excellent oxidation resistance and good mechanical properties. However, the effect of process conditions on the creep properties of the FeCrAl alloy is not clear till now. In this study, the impact of a process condition of hot-rolling on the creep properties of FeCrAl alloy was investigated using a nano-indentation creep test under a temperature of 350°C. The microanalysis results indicated that the grain size became smaller with the increase of the hot-rolling thickness reduction. The nano-indentation creep test results showed that the creep power-law stress exponent was about four, and the creep resistance increased when the hot-rolling thickness reduction increased.
Compound Heterozygosity for KLF1 Mutations Causing Hemolytic Anemia in Children: A Case Report and Literature Review
Authors: Xu Linlin , Zhu Dina , Zhang Yanxia , Liang Guanxia , Liang Min , Wei Xiaofeng , Feng Xiaoqing , Wu Xuedong , Shang Xuan
Published: June 2021

Background

Anemia is one of the most common diseases affecting children worldwide. Hereditary forms of anemia due to gene mutations are difficult to diagnose because they only rely on clinical manifestations. In regions with high prevalence of thalassemia such as southern China, pediatric patients with a hereditary hemolytic anemia (HHA) phenotype are often diagnosed with β-thalassemia. However, HHA can be caused by other gene defects. Here, a case previously diagnosed with thalassemia in a local hospital was sent to our laboratory for further genetic diagnosis. Preliminary molecular testing did not identify any mutations in globin genes.

Methods

All blood samples were collected after informed consent had been obtain from the proband’s parents. Both clinical and genetic analyses were conducted for the patient and her family members, including clinical data collection and sequencing of the KLF1 gene. Relevant literature was reviewed, including genetically confirmed cases with well-documented clinical summaries.

Results

Based on the detailed clinical data for this case, we diagnosed the patient with severe HHA. Sanger sequencing confirmed that there was a mutation on each KLF1 allele in the proband, which is missense mutation c.892G > C (p.Ala298Pro) inherited from father and frameshift mutation c.525_526insCGGCGCC (p.Gly176Argfs∗179) from the mother, respectively. A summary of the KLF1 mutation spectrum and a clarification of genotype–phenotype correlation were performed through a combined analysis of the case and literature studies.

Conclusion

This study corrected the misdiagnosis and identified the etiology in a Chinese patient with HHA. Identification of the disease-causing gene is important for the treatment and care of the patient and prevention of another affected childbirth in her family. In addition, this study provided insight to better distinguish HHA patients with β-thalassemia mutations from those with KLF1 mutations.
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism
Authors: Shao Ying , Saredy Jason , Xu Keman , Sun Yu , Saaoud Fatma , Drummer Charles , Lu Yifan , Luo Jin J. , Lopez-Pastrana Jahaira , Choi Eric T. , Jiang Xiaohua , Wang Hong , Yang Xiaofeng
Published: June 2021

To characterize transcriptomic changes in endothelial cells (ECs) infected by coronaviruses, and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) were examined in 28 EC microarray datasets with 7 monocyte datasets as controls. We made the following findings: The majority of IGs are upregulated in the first 12 hours post-infection (PI), and maintained until 48 hours PI in human microvascular EC infected by middle east respiratory syndrome-coronavirus (MERS-CoV) (an EC model for COVID-19). The expressions of IGs are modulated in 21 human EC transcriptomic datasets by various PAMPs/DAMPs, including LPS, LPC, shear stress, hyperlipidemia and oxLDL. Upregulation of many IGs such as nucleic acid sensors are shared between ECs infected by MERS-CoV and those stimulated by PAMPs and DAMPs. Human heart EC and mouse aortic EC express all four types of coronavirus receptors such as ANPEP, CEACAM1, ACE2, DPP4 and virus entry facilitator TMPRSS2 (heart EC); most of coronavirus replication-transcription protein complexes are expressed in HMEC, which contribute to viremia, thromboembolism, and cardiovascular comorbidities of COVID-19. ECs have novel trained immunity (TI), in which subsequent inflammation is enhanced. Upregulated proinflammatory cytokines such as TNFα, IL6, CSF1 and CSF3 and TI marker IL-32 as well as TI metabolic enzymes and epigenetic enzymes indicate TI function in HMEC infected by MERS-CoV, which may drive cytokine storms. Upregulated CSF1 and CSF3 demonstrate a novel function of ECs in promoting myelopoiesis. Mechanistically, the ER stress and ROS, together with decreased mitochondrial OXPHOS complexes, facilitate a proinflammatory response and TI. Additionally, an increase of the regulators of mitotic catastrophe cell death, apoptosis, ferroptosis, inflammasomes-driven pyroptosis in ECs infected with MERS-CoV and the upregulation of pro-thrombogenic factors increase thromboembolism potential. Finally, NRF2-suppressed ROS regulate innate immune responses, TI, thrombosis, EC inflammation and death. These transcriptomic results provide novel insights on the roles of ECs in coronavirus infections such as COVID-19, cardiovascular diseases (CVD), inflammation, transplantation, autoimmune disease and cancers.
Changes of Serum IgG Glycosylation Patterns in Primary Biliary Cholangitis Patients
Authors: Zeng Xiaoli , Li Siting , Tang Shiyi , Li Xi , Zhang Guoyuan , Li Mengtao , Zeng Xiaofeng , Hu Chaojun
Published: June 2021

Objective

Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease whose diagnosis is based significantly on autoantibody detection. This study aims to investigate the glycosylation profile of serum IgG in PBC patients using high-throughput lectin microarrays technology.

Method

Lectin microarray containing 56 lectins was used to detect and analyze the expression of serum IgG glycosylation in 99 PBC patients, 70 disease controls (DCs), and 38 healthy controls (HCs). Significant differences in PBC from control groups as well as across PBC subgroups positive for various autoantibodies were explored and verified by lectin blot technique.

Results

Lectin microarray detection revealed that compared to DC and HC groups, the specific glycan level of serum IgG sialic acid in PBC patients was increased. For each PBC subgroup, glycan levels of IgG mannose and galactose were decreased in AMA-M2 positive PBC patients compared to the AMA-M2 negative group. IgG N-Acetylgalactosamine (GalNAc) and fucose were decreased in anti-sp100 positive patients. IgG galactose was increased in anti-gp210 positive patients. IgG mannose was decreased in ACA-positive patients. Although the difference in overall sialic acid level was not observed using lectin blot, all results among the above PBC subgroups were consistent with the results of the technique.

Conclusion

Lectin microarray is an effective and reliable technique for analyzing glycan structure. PBC patients positive for different autoantibody exhibits distinct glycan profile. Altered levels of glycosylation may be related to the occurrence and development of the disease, which could provide a direction for new biomarker identification.