bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Multidimensional Vulnerability of Lagging Regions: A Case Study of New Valley Governorate Egypt
Authors: Badawy Mahmoud Mohamed , Elmouety Ebtehal Ahmed Abd , Mahmoud Mostafa Monir
Published: October 2022

In recent years, regional cohesion policies have received increasing attention worldwide. Therefore, international organizations, governments, and researchers have sought to assess the vulnerability in lagging regions. However, most studies have focused on exposure to a particular risk, with little work to examine overall interactions or adaptability from a multidimensional perspective. This study aims to fill the current research gap by developing a multidimensional composite index using the IPCC approach and a Delphi survey to define the criteria and specify the weights of the variables by the AHP method. The results showed that the municipality, which has an adaptive capacity through physical and economic capabilities, has overcome environmental, social, and demographic risks. On the other hand, some municipalities have been affected by their isolation, resulting in a high sensitivity to economic, social, and demographic challenges. A quantitative assessment of the various aspects of vulnerability and adaptability assists experts in mitigating the effects of vulnerability through management, planning, and decision-making; developing appropriate strategies; and serving as a manual for governments in managing vulnerability decrease to achieve sustainable development.
Evaluating the Level of the Shuttle Service Quality at Al al-Bayt University Campus Using the SERVQUAL Model
Authors: Taran Ayed Mohammad
Published: October 2022

This paper mainly adopts descriptive analysis method and case study method and uses SERVQUAL model and statistical method to measure and evaluate the service quality level of shuttle bus of Al al-Bayt University. The study concluded that the order of the dimensions of measuring the quality of shuttle service was as follows: assurance, reliability, and empathy at a medium level; then tangibility followed by responsiveness at a low level for each. In general, the students' satisfaction level with the shuttle services provided at the campus was low, especially for the tangibility and responsiveness dimensions. This research is of value to transport service providers in understanding the gaps in and requirements of their service provision. To policy makers it highlights the dissatisfaction in the current levels of public transport service, as well as providing some indication of areas in which future interventions can be directed.
Internal Feelings of Hijab: The Lived Experiences of Chinese Young Muslim Women in Guangzhou
Authors: Embong Abdul Mutalib , Chunyan Sha , Arzaman Ameer Farhan Mohd , Kadhim Kais A. , Abdul-Kadir Nurul Ashikin , Nasir Nur Yuhanis Mohd , Kasim Johari , Baharuddin Syahrul Alim , Azizan Hasfa Zaima
Published: October 2022

Ethnic identity is considered a fundamental aspect that provides an individual with a sense of belonging and commitment to a particular ethnic group. Wearing Hijab, for example, is a major consensus and obligation for Muslim women. This article focuses on the status of the hijab among young Muslim women in Guangzhou, China. Living in one of the world's socialist states, they are struggling with their identity and faith as a minority. This paper study of how they negotiate their ethnic identities within and outside their families. The study draws data gathered from semi-structured interviews with nine young Muslim women. The findings suggest (1) Ethnic identity is a dynamic process. (2) Social and cultural contexts have great effects on an individual’s ethnic identity development. (3) Ethnic identity is multidimensional: family, friends, gender, and religion play vital roles in the process of achieving a positive ethnic identity. Prior to this, Muslim women find Hijab as one of the major barriers to living in mainstream society. They choose to wear Hijab or not, based on the above reasons. They may find out more possible ways of educating their members to consider religion as a potential source of empowerment and strength in their identity.
Risk Perception and Communication in the Porto Region (PR), Portugal
Authors: Martins Bruno , Nunes Adélia , Sousa Miguel
Published: October 2022

Porto region (PR) is located on the northern coast of Portugal characterised by a complex set of risks occurrence. With the purpose of understanding what factors determine risk perception, a questionnaire entitled “Risk Perception in PR” was applied to 244 subjects. Analysis of variance (ANOVA) was performed. The results indicated that certain socio-demographic characteristics of the respondents’ education and age correlated with risk perception. The study also shows statistical differences between the groups in relation to how the risk is communicated. These findings can help decision makers to improve effective risk communication policies and risk reduction strategies.
Plant-based diets contribute to lower circulating leptin in healthy subjects independently of BMI
Authors: Gogga Patrycja , Janczy Agata , Szupryczyńska Natalia , Śliwińska Aleksandra , Kochan Zdzisław , Malgorzewicz Sylwia
Published: October 2022

Much research has shown how important role leptin – a hormone secreted by adipose tissue – plays in the regulation of human body weight, mainly due to its appetite-decreasing effects. Under the conditions of energy balance, leptin is an indicator of the amount of triglycerides stored in adipose tissue. In contrast, in a state of hunger or overeating, it acts as an energy balance sensor, and when its level is too high, it fails to reduce food intake, disturbing maintenance of the proper body mass. Recent studies indicate that there is a relationship between a vegetarian diet and the decreased incidence of cardiovascular diseases, certain types of cancer and obesity. It has been noted that people on plant-based diets have lower body weight and percentage of body fat than omnivores. The aim of the study was to analyze the relationship between serum leptin concentrations and the type of diet. The 143 female volunteers on a vegetarian, vegan or omnivore diet were enrolled in the study. All participants had normal body weight (BMI≥18.5<24.9kg/m2). There were statistically significant differences in the serum leptin concentrations of the studied women. Both in the group of vegetarians and vegans circulating leptin was significantly lower (p<0.001) than in the group of omnivores, with the lack of differences in neither BMI nor in body fat content. This suggests that leptin levels are affected not only by the amount of stored fat, but also by the consumed food. This observation indicates the health-promoting properties of plant diets, by influencing circulating leptin.
Qualidade do Disclosure em Responsabilidade Social Corporativa e seu impacto no nível de assimetria informacional em empresas listadas na B3.
Authors: Monteiro Alexandre Fernandes , Gonçalves Rodrigo de Souza
Published: October 2022

Partindo de evidência que indicou haver relação negativa entre qualidade do social disclosure (QSD) e custo do capital (CK) (Gonçalves et al, 2013) e com base em estudos que apontam para a relação ambígua entre CK e assimetria informacional (AI) (Lambert et al 2011; Armstrong et al, 2011), investiga-se o relacionamento QSD e AI em companhias abertas brasileiras. Verificou-se por meio de regressão logística uma relação negativa significante entre QSD, medida pelo índice de social disclosure (ISD), e AI medida pelo bid-ask-spread no prazo de 10 dias após divulgação do resultado anual. Os achados confirmam literatura pregressa acerca da relação entre qualidade do disclosure e AI, focando em uma das dimensões da responsabilidade social corporativa, e apresentam evidências dos fatores causadores da AI
Increasing the reliability and resource of power stations of automatic lines
Authors: Zamuragin Yu.M. , Salamandra K.B.
Published: October 2022

For technological operation of pressing, punching, riveting, bending, etc. mechanisms are used to transform the movement of the executive link, which provides the required force impact on the processed materials. The paper discusses the original mechanism of the power station of the automatic packaging line ALB 165. The analysis of the power stroke lever of the power station showed an insufficient margin of safety, which was the reason for the mechanism failure. Based on the calculations performed, options for modernizing the design of the lever were proposed, which made it possible to reduce the maximum stresses and displacements in the part by 30 and 32 %, respectively.
Sposób postrzegania przeszłości jako światło dla μελέτη θανάτου. Przyczynek z odniesieniem do myśli parmenidesa z elei (B3)
Authors: Wandowicz Mieszko
Published: October 2022

Celem mojego artykułu jest przedstawienie refleksji na temat związku między sposobem istnienia przeszłości (tym, jak wolno ją postrzegać) a podejściem do umierania oraz śmierci. Leżąca u podstaw moich rozważań interpretacja Platońskich słów „μελέτη θανάτου” (Fedon, 81 a) w zestawieniu z Parmenidejskim „τὸ γὰρ αὐτὸ νοεῖν ἐστίν τε καὶ εἶναι” (Περί φύσεως, B3) wydaje się dozwolonym i korzystnym intelektualnie rezultatem spojrzenia na te wyimki w świetle ἄσκησις: filozofii pojmowanej jako sposób rozumnego życia-umierania. Jednym z ważnych przesłań filozofii starożytnej zdaje się pogląd, że to, o czym da się pomyśleć, musi istnieć. Wówczas — jako że myślenie (wspominanie) o tym, co wydarzone, jawi się rzetelniejsze niż przewidywanie tego, co dopiero się zdarzy — należy przydać przeszłości odmienny status ontyczny aniżeli przyszłości. Jeśli zaś sięgnąć, dla przykładu, po współczesną teorię rosnącego wszechświata (C. D. Broad; growing [block] universe theory), wtedy wolno — być może — uznać czyjąś śmierć za kolejną warstwę jego istnienia, nie destruującą warstw poprzednich. Pozwala to zmienić postrzeganie przyszłego bądź aktualnego „braku” osoby zmarłej, jak i nieuniknionego zbliżania się (do) śmierci.
Impact of Climate Change on Agriculture and Its Allied Sectors: An Overview
Authors: Begum Mahima
Published: October 2022

Global climate change is one of the rising international issues of modern civilization. It has impacted the way of living of each and every organism. The agricultural sector is one such highly impaired sector that has been affected by climate change. With the rise of atmospheric temperature, soil conditions get worsened; the normal physiology of plants has also changed, ultimately resulting in lesser yield as compared to yield potential yield. The agricultural sector has a significant impact on the Economy of the country. The reduction in yield due to climate change has resulted in a decrease in monetary return. The impaired quality of the product in terms of nutrients, minerals, antioxidants, and other biochemical content has induced various diseases and deficiencies in plants and animals. The plant becomes highly susceptible to pests and pathogens. Other allied sectors like animal husbandry, fishery, poultry etc., also get affected due to the changes in weather parameters. Climate change has a clear and profound impact on the food web, health and Economy of every living being on the Earth. Researches and experiments should be conducted to find out future trends and mitigation techniques to cope with global climate change.
Impact of COVID-19 and Climate Change on Indian Agriculture
Authors: Pooja Pooja
Published: October 2022

Climate change and pandemics both disrupt global food supply chains on their own. Natural and human disasters, such as droughts, cyclones and pandemics, have become more common in the twenty-first century. Their combined effects can result in severe economic stress and malnutrition, especially in developing nations. Understanding how climate change and pandemics interact and developing strategies to address them both together and separately is critical to ensuring a stable global food supply. This paper examines the consequences of these disasters in terms of food and agriculture and then discusses how they are compounded. We discuss the implication of policy and suggest research topics for the future.
Genetic Diversity of Seed Storage Proteins in Pigmented and Non-pigmented Indigenous Paddy (Oryza sativa L.) Landraces of Assam, India
Authors: Gupta Manjusha Das , Handique Arun Kumar
Published: October 2022

Background: Pigmented rice particularly, red and black rice have come into prominence due to their promising antioxidant property. In Assam, all major ecotypes of paddy viz., Ahu, Sali, Bao, Boro have large number of indigenous landraces with red kernel. Although Assam is recognised as a secondary centre of origin and diversity yet gene erosion is assuming serious proportion. It is acknowledged that many indigenous cultivars are facing extinction and there is apprehension that many may be lost even before they are evaluated and characterised. Among different methods, seed protein profile is recognised as fingerprint for a race by International Seed Testing Association (ISTA) as it can resolve interspecific and intraspecific variation without ambiguity. Methods: The present study involves, molecular characterisation and genetic diversity analysis of pigmented and non-pigmented landraces. Seed protein profiles for the paddy landraces were worked out by SDS-PAGE. SDS-PAGE was carried out with two phase gradient buffer system with upper stacking gel and lower separating gel to ensure denaturation of protein while migrating through it. Result: Among the twenty landraces a total of 15 proteins bands were observed in the size range of 12.1 Kd to greater than 122.0 Kd. Highest protein bands were observed in cultivar Ranjit Amon, Bismuthi and Boro (ecotype) all with 15 protein bands. On the other hand, lowest protein bands were recorded in Amona with only 9 bands. Among the protein bands six with molecular weight greater than 122.0 Kd; 112.0 Kd; 97.4 Kd, 90.0 Kd and 15.0 Kd were consistently found in all the landraces. The dendrogram revealed a total of four clusters. The landrace Amona (red) did not belong to the any cluster and most distantly related to others. On the other hand, some are genetically identical. Agnisali, Suhagmani and Tengeri (all white) had no genetic distance between them and hence identical at molecular level. Within the same cluster both red and white rice landraces were observed. Our study suggested that several proteins bands were detected only on specific rice and it could be as biochemical markers for further research.
Classification of Cardiovascular Disease Gene Data Using Discriminant Analysis and Support Vector Machine (SVM)
Authors: Prayogo Rizky , Anggraeni Dian , Hadi Alfian Futuhul
Published: October 2022

Cardiovascular disease is a disease caused by impaired function of the heart and blood vessels. This disease is caused by many factors, one of which is genetics, while the causes are age, gender, and family history. In this study, classification of 62 individuals with normal response and cardiovascular disease was carried out. Discriminant Analysis (AD) is a method that classifies data into two or more groups based on several variables where data that has been entered into one group will not be included in another group. The Support Vector Machine (SVM) performs classification by building an N-dimensional hyperplane that optimally separates data into two categories in the input space. Furthermore, AD and SVM will be compared to get which method has the best accuracy, after that it will be added to clustering using k-means and k-means kernels to improve the accuracy of each method. The results of this study are AD and SVM have accuracy values of 83.33% and 91.66%, for AD and SVM which are subjected to k-means have accuracy values of 91.66 % and 91.66 %, and for AD and SVM subjected to k-means kernel has an accuracy value of 100 % and 100 %.
Extraction and Characterization of Fe2O3 from Red Mud PT. Indonesia Chemical Alumina West Kalimantan
Authors: Wahyinto Indi Rizki , Aritonang Anthoni B. , Zaharah Titin Anita
Published: October 2022

Red Mud is a term used for residues or waste materials from bauxite refining. One of the main compositions of red mud is Fe2O3. This study aims to obtain the optimum extraction of Fe2O3 conditions or hematite by using APDC ligands and knowing the characteristics of Fe2O3 generated. In this study, Fe2O3 extraction begins to determine the optimum pH and ligand concentration. The results of determining the optimum conditions showed pH 1 and ligand concentration of 0.5 M. Fe2O3 characteristics can be resolve through the characterization of Fourier Transformed Infra Red (FTIR), X-ray Diffraction (XRD) and X-ray Fluorescence (XRF). The results of FTIR characterization showed the stretching vibration of Fe-O Fe2O3 phase (570.50 cm-1 and 470.20 cm-1), XRD diffractogram showed the resulting crystal shape is rhombohedralsize is 27,08 nm, while the XRF characterization results showed the mass percent Fe2O3 before extraction is 42.48% and the mass percent Fe2O3 after extraction is 72.443%.
Tree Ferns of C. contaminans and C. orientalis from Biosite Erek-erek Geoforest of Ijen Geopark, Banyuwangi
Authors: Ulum Fuad Bahrul , Setyati Dwi
Published: October 2022

The tree ferns abundant in the ecotourism area of the geoforest erek-erek biosite is represented as ancient plants. However, species list and their composition as diversity richness data is still lacking the in the conservation area. The aims of of this study was to determine the tree ferns and provide the description of the species. Observations on the morphological characters of plants were carried out directly in the field of tree ferns habitat at the Ijen geopark, Banyuwangi, while other morphological and anatomical determinations were conducted in laboratory. The tree ferns identified in the erek-erek forest were two species i.e., Cyathea contaminans and Cyathea orientalis. The main distinguishing characteristics of these species are: stem height, stem surface, attachment of the remaining petiole, scale color, crozier size, indusium and spore shape. This article also provides descriptions of the species and the information regarding conspicuous characters that can be used for species determination in the field. We also propose further conservation efforts to preserve the tree ferns in their habitat.
Comparative Analysis of CPM, PDM and PERT Methods in Ship Repair Scheduling Planning KN. RB 309 Ternate 01
Authors: Oktafiana Laily Okta , Baroroh Intan
Published: October 2022

A ship that is still carrying out sailing activities must always be in a state that is in accordance with the classification and statutory. Maintenance or repair is needed for the ship in order to stay in good condition and fit to sail. In a ship repair project, there are several important aspects that need to be considered in order to complete project activities quickly and precisely. PT. XYZ has carried out ship repair activities, but the repair activities have been delayed due to weather factors, and the late procurement of spare parts. This research was conducted by analyzing the three models of scheduling fiberglass ship repair projects using Microsoft excel and using the CPM (Critical Path Method), PDM (Precedence Diagram Method) and PERT (Project Evaluation and Review Technique) methods. Results from the CPM method on 48-day A scheduling, 33-day B scheduling, and 21-day C scheduling. Pdm method results scheduling A 48 days, scheduling B 33 days, and scheduling C 21 days. In the PERT method the project can be completed in 48 days which is 48.67%, scheduling B 34 days 5 hours 21 minutes with the possibility of a KN ship repair project. RB 309 Ternate 01 can be completed in 48 days i.e. 99.35% and scheduling C 22 days 5 hours 21 minutes with the possibility of a KN ship repair project. RB 309 Ternate 01 can be completed in 48 days which is 99.99%.
Analysis on the Effects of Logistics Efficiency on Korea’s Trade Flows in RCEP Signatories
Authors:   IAGBT, Lee Seo-Young
Published: October 2022

Purpose - The purpose of this study is to analyze the effect of logistics efficiency in RCEP signatory countries on Korea’s trade. In particular, after analyzing the effects of individual indicators of the logistics performance index (LPI) on trade, policy implications are drawn based on the results.
Design/Methodology/Approach - In order to analyze the effect of logistics efficiency in RCEP countries on Korea’s trade, the independent variables of the gravity model included GDP, population, distance, and LPI. For detailed analysis, in addition to the LPI, the individual indicators of LPI are input to the independent variable for analysis. This study adopts varying coefficient models, the random effects model and fixed effects model, in order to more effectively analyze unobservable factors in the panel data.
Findings - The empirical evidence using the gravity model showed that the coefficient of LPI was about 1.7 and statistically significant at the 1% level of significance. In other words, if the logistics efficiency of the RCEP signatory country increases by 1%, when other variables are constant, Korea’s trade volume increases by about 1.7%. As a result of analyzing the effect of LPI’s individual indicators on trade, it was found that the five individual indicators of logistics infrastructure, international shipment, logistics service, timeliness, and goods tracking affect trade. On the other hand, the clearance index was not statistically significant at any significance level.
Research Implications - It was confirmed that the logistics efficiency of RCEP signatory countries is important for Korea’s trade facilitation. In other words, if not only Korea’s logistics efficiency but also the logistics efficiency of the RCEP signatory countries are improved, the facilitation of trade between the two countries can be achieved. To this end, it is necessary to reduce the logistics cost through the establishment of the logistics infrastructure, and it is also necessary to make efforts to increase logistics efficiency.
The Choice of Trade Policy in an International Differentiated Duopoly with Process R&D Investment under Uncertainty
Authors:   IAGBT, Yang Il-Seok
Published: October 2022

Purpose - The purpose of this paper is to investigate equilibrium pairs of modes of government intervention in an international differentiated duopoly with process R&D investment under uncertainty. Governments in each of the two countries choose direct R&D investment and quantity controls, or R&D subsidies to shift profits towards domestic firms.
Design/Methodology/Approach - For the analysis, we extend the model of Haaland and Kind (2008) to that with uncertainty and consider direct R&D investment and quantity controls besides R&D subsidies. Firms in each of the two countries produce differentiated products and governments in each compete via direct R&D investment and quantity controls, or R&D subsidies in a third-country market. In environments with low, high, and intermediate uncertainty, equilibrium pairs of modes of government intervention are examined.
Findings - It is shown that (i) in an environment with low uncertainty, direct R&D investment and quantity controls by each government is a unique equilibrium if the goods are substitutes and not too close, and R&D subsidies by each government is a unique equilibrium if the goods are complements and not too close; (ii) in an environment with high uncertainty, R&D subsidies by each government is a unique equilibrium regardless of the nature of the goods, except in the cases of too close substitutes and complements; and (iii) in an environment with intermediate uncertainty, R&D subsidies by each government is a unique equilibrium if the goods are complements and not too close. Moreover, in an environment with intermediate uncertainty, there are two symmetric equilibria if the goods are substitutes and not too close and there are two asymmetric equilibria if the goods are substitutes and very close.
Research Implications - By analyzing the effects of direct R&D investment and quantity controls, and R&D subsidies in international markets under uncertainty, we can expect which government intervention appears in equilibrium.
Non-local problem with an integral condition for a parabolic equation with a Bessel operator
Authors: Garipov Ilnur B. , Mavlyaviev Rinat M.
Published: October 2022

For the parabolic equation with the Bessel operator
∂u/∂t=(∂^2 u)/(∂x^2 )+k/x ∂u/∂x
in the rectangular domain 0<x<l, 0<t≤T, we consider a boundary value problem with the non-local integral condition of the first kind
∫_0^l▒〖u(x,t)xdx=0, 0≤t≤T.〗
This problem is reduced to an equivalent boundary value problem with mixed boundary conditions of the first and third kind. It is shown that the homogeneous equivalent boundary value problem has only a trivial zero solution, and hence the original inhomogeneous problem cannot have more than one solution. This proof uses Gronwall’s lemma. Then, by the method of spectral analysis, the existence theorem for a solution to an equivalent problem is proved. This solution is defined explicitly in the form of a Dini series. Sufficient conditions with respect to the initial condition are obtained. These conditions guarantee the convergence of the constructed series in the class of regular solutions.
Logos and Political Order. Representation in the Political Philosophy of Eric Voegelin
Authors: Torres Bernat
Published: October 2022

This article aims to show the anthropological and political relevance of logos or rationality as understood by Eric Voegelin. The paper is divided into two parts, the first elaborates what Voegelin considers to be the discovery of logos by Plato and Aristotle, which represents a historical and at the same time epistemological phenomenon of self-illumination of the human psyche. Through the concept of logos, the human soul is discovered and, with it the political reality can be ordered and organized. The second part of the article focuses on this political dimension of logos or rationality as an element that allows the foundation of political science as it is exposed in Voegelin’s The New Science of Politics (1952), and the concept of political representation as a central element of Voegelin’s political philosophy is explored.
Developing a Sense of Justice
Authors: Irrera Elena
Published: October 2022

In this paper I offer a conceptual characterization of the idea of a “sense of justice” as a suitable motivational basis for respect for the principles of justice in force in a given society, and argue that a similar concern can be found not only in John Rawls, who expressely talks about that notion, but also in Aristotle. My main contention is that both thinkers invite readers to conceive of the sense of justice as an attitude admitting of various degrees, ranging from a fear-inspired respect for the law up to an unconditional appreciation of the established constitutional principles and the laws stemming fom such principles. In the first part of this paper, I will address Aristotle’s view of a natural capacity of human beings for sociability, political participation and functional interdependence within the city culminating in a virtue-based political friendship. In the second part I will contend that, in Rawls’ view, the individual sense of justice is at work not only after the establishment of a public conception of justice (contrary to what a prima facie reading of A Theory of Justice might suggest), but also in a phase ante legem.
Analysis of COVID-19 Surveillance System at Makassar City Health Office 2020
Authors: Fatmasari  , Syahrul Fariani , Darajat Zakiah , Kusuma Eva Flourentina
Published: October 2022

One of the infectious diseases that emerged in Indonesia in 2020 has been designated as a COVID-19 pandemic since March 11, 2020, and until now, the pandemic has not been completed. Surveillance has a role in providing information on targeted disease control activities; analyzed the COVID-19 surveillance system based on the current system approach at the Makassar City Health Office. Methods This research is a descriptive observational study conducted in September-October 2020. Data collection was carried out using in-depth interviews with people who were key informants of COVID-19 surveillance activities. There are four informants in this study. In addition, secondary data was obtained from the P2P field regarding COVID-19 cases. In general, the Input component has not been fulfilled; HR has multiple tasks, the job desk is irregular, and several important forms are not used in the methods section. The process component has been running but has not been maximized because there are still incomplete data, no reports based on the PE form, the All-Record TC-19 information system has not been used, and data analysis is still incomplete, data analysis is not equipped with data interpretation. In the Output component, the success rate for public health surveillance criteria has not been evaluated, and the dissemination of information has been carried out well across sectors. The implementation of COVID-19 surveillance at the Makassar City Health Office has been carried out well, but some things are still not optimal.
Bacterial Profile and Antibiotic Resistance Pattern among Children with Urinary Tract Infections in Dr. Soetomo Hospital, Surabaya, Indonesia
Authors: Adhima Fauziah , Wahyunitisari Manik Retno , Prasetyo Risky Vitria , Setiabudi Rebekah Juniati
Published: October 2022

Urinary tract infections (UTIs) are the most common infections in pediatric patients characterized by the growth of bacteria in the urine in significant numbers. Antibiotics remain the primary treatment of UTI in children. However, there has been an increase in antibiotic resistance to uropathogens worldwide due to their inappropriate and extensive uses. There is considerable geographical variation in the distribution of bacteria and antibiotic resistance pattern. Thus, to prevent further resistance and provide empirical antibiotic options, this study aims to determine the profile of bacteria and antibiotics resistance pattern among UTI pediatric patients in Dr. Soetomo Hospital. This study was performed by collecting data from the urine culture logbook at the Clinical Microbiology Laboratory of Dr. Soetomo Hospital in July-October 2019. The sample was UTI patients aged one day – 18 years due to bacterial infection with a colony count of   ≥100,000 CFU/ml. In this study, 131 patients showed significant bacterial growth dominated by males and ages one month – 2 years. UTI were caused by gram-negative bacteria (74%) and gram-positive bacteria (26%), with the most bacteria found in each group were Escherichia coli and Enterococcus faecalis. E. coli showed ≥70% resistance to ampicillin, cefazoline, piperacillin, tetracycline, and trimethoprim-sulfamethoxazole. Comorbidities were dominated by hydronephrosis (10.98%), chronic kidney disease (9.79%) and hydrocephalus (8.09%). In conclusion, gram-negative bacteria were the leading cause of UTI in children with E. coli as the most common uropathogen, highly resistant to ampicillin and cefazolin. Gram-positive bacteria were less frequent with varied resistance patterns. Most common comorbidity was hydronephrosis.
The Activities on Prevention of Malaria and Filariasis Vector Bites among Indonesian Society: A Nationwide Disease Prevention Survey
Authors: Widawati Mutiara , Ipa Mara , Astuti Endang Puji , Wahono Tri , Yuliasih Yuneu
Published: October 2022

Vector Borne Diseases are diseases that cause many problems. These diseases are spread by mosquitoes as the vectors. They transmit parasites to humans through their bites. The people who live in Indonesia have several characteristics that make them vulnerable to these diseases. Therefore, it is necessary to explore these characteristics in order to gain better prevention promotional targeting strategy. This study aims to determine the factors that can influence mosquito bite prevention behaviour in Indonesian society.  The data from a nationwide survey research were used with a cross sectional design conducted once in every five years.  The Riskesdas was conducted from April to May 2018 in all districts in Indonesia. The influencing factors observed were including experience of exposure to vector borne diseases (malaria or filariasis), gender, age group, education level and area of residence. This study conducted a multivariate test using logistic regression analysis to determine the factors that influence mosquito bite prevention behaviour. The results demonstrated that the factors of experience of exposure to vector borne diseases, gender, age group, education level and area of residence could determine the mosquitoes bite prevention behaviour in Indonesian society. Respondents who have experience of being exposed to malaria or filaria, under 60 years old, women, college graduates, and rural communities are more likely to prevent mosquito bites, therefore they could be empowered in promoting public awareness towards mosquito bites prevention.
Students’ perceptions of the accounting department on the factors affecting accountants’ ethical behavior
Authors: Hidayati Umi rizeki , Nor Wahyudin , Safrida Lili
Published: October 2022

This study was conducted to examine and analyze the influence of academic self-efficacy, fraud diamond, knowledge level, Machiavellian, and love of money on accountants' ethical behavior. Research respondents were students of the Accounting Department University of Lambung Mangkurat Banjarmasin; Sekolah Tinggi Ilmu Ekonomi Indonesia Banjarmasin (STIEI) Banjarmasin; National College of Economics (STIENAS) Banjarmasin; and Pancasetia College of Economics (STIEPAN) Banjarmasin. The data were processed using multiple linear regression analysis with classical assumption test. The results of the research prove that academic self-efficacy and level of knowledge have a significant negative effect on the ethical behavior of accountants. Meanwhile, fraud diamond and machiavellian have an insignificant positive effect on the ethical behavior of accountants, and love of money has a significant positive effect on the ethical behavior of accountants.
Flexible Loads Scheduling Algorithms for Renewable Energy Communities
Authors: Fonseca Tiago , Ferreira Luis Lino , Landeck Jorge , Klein Lurian , Sousa Paulo
Published: October 2022

Renewable Energy Communities (RECs) are emerging as an effective concept and model to empower the active participation of citizens on the energy transition, not only as energy consumers, but also as promoters of environmentally friendly energy generation solutions. This paper aims to contribute to the management and optimization of individual and community Distributed Energy Resources (DER). The solution follows a price and source-based REC management program, in which consumers day-ahead flexible loads (Flex Offers) are shifted according to electricity generation availability, prices and personal preferences, to balance the grid and incentivize user participation. The heuristic approach used in the proposed algorithms allows the optimization of energy resources in a distributed edge and fog approach with a low computational overhead. The simulations performed using real world energy consumption and flexibility data of a REC with 50 dwellings show an average cost reduction of 10.6% and an average increase of 11.4% in individual self-consumption. Additionally, the case-study demonstrates promising results regarding grid load balancing and the introduction of intra-community energy trading.
Validation the DNA Methylation Landscape of TFF1/TFF2 in Gastric Cancer
Authors: Qian Ze , Jiang Yifan , Shou Chunhui , Yu Jinghua , Huang Dongdong , Xie Haiyang , Zhou Lin , Chen Diyu , Zheng Shusen
Published: October 2022

Gastric cancer (GC) is one of the most common malignancies around the world, and the incidence of GC is increasing in the past decades. In addition to genetic modifications, epigenetic alterations catalyzed by DNA methyltransferases (DNMTs) are a well-characterized epigenetic hallmark in gastric cancer. Nowadays, DNA methylation landscape is essential for maintaining the silence of tumor suppressor genes (TSGs). As an important group of peptide, TFF family has been confirmed to function as a TSG in various kinds of cancers. However, whether TFFs could be modified by DNA methylation in gastric cancer remains unknown. In this study, we initially screened out two expression profiles about GC from Gene Expression Omnibus (GEO) database. The higher expressions of TFF1 and TFF2 were observed in GC tumor tissues than normal tissues. Additionally, we illustrated that the expressions of TFF1/TFF2 were associated to the overall survival (OS) and tumor free survival (TFS) of GC patients via through the Kaplan-Meier analysis. Subsequently, the integrative analysis was performed to estimate the DNA methylation level of each site in TFF1/TFF2 CpG islands. Importantly, our findings indicated that hyper-methylation of cg01886855 and cg26403416 were separately responsible for the downregulation of TFF1 and TFF2 in GC samples. Besides, utilizing the gain of function assay, we demonstrated that TFF1/TFF2 could suppress the proliferation of GC cells. Based on these results, We identified that TFF1 and TFF2 acted as the putative tumor suppressors in gastric cancer, which suggested that TFFs could be two candidate biomarkers for predicting tumor recurrence in gastric cancer patients. Furthermore, these findings highlight a potential therapeutic approach in targeting the TFFs for the treatment of gastric cancer.
Genome-Wide Characterization of Sulfate Transporter Gene Family in Oilseed Crops: Camelina sativa and Brassica napus
Authors: Heidari Parviz , Hasanzadeh Soosan , Faraji Sahar , Ercisli Sezai , Mora-Poblete Freddy
Published: October 2022

Sulfate transporters (SULTRs) are responsible for the uptake of the sulfate (SO42−) ions in the rhizosphere by the roots and their distribution in plant organs. In this study, SULTR family members in the genome of the two oilseed crops, Camelina sativa, and Brassica napus, were identified and characterized based on their sequence structure, duplication events, phylogenetic relationships, phosphorylation sites, and expression levels. Herein, 36 and 45 putative SULTR genes were recognized from the genome of C. sativa, and B. napus, respectively. SULTR proteins were predicted as basophilic proteins with low hydrophilicity in both studied species. According to phylogenetic relationships, we divided SULTRs into five groups, in which SULTRs 3 showed highest variation. Besides, several duplication events were observed between SULTRs. The first duplication event was predicted approximately five million years ago between three SULTRs 3.1 in C. sativa. Two subunits were indicated in the 3D structure of SULTRs that the active binding sites differed between C. sativa and B. napus. According to available RNA-seq data, SULTRs showed diverse expression in tissues and response to stimuli. SULTRs 3 showed an expression in all tissues. SULTRs 3.1 were more upregulated in response to abiotic stresses in C. sativa, while SULTRs 3.3, and SULTRs 2.1 showed an upregulation in B. napus. Furthermore, SULTRs 3 and SULTRs 4.1 showed an upregulation in response to biotic stresses in B. napus. Based on the distribution of cis-regulatory elements in the promoter region, we speculated that SULTRs might be controlled by phytohormones such as ABA, and MeJA. Therefore, it seems that SULTR genes in C. sativa have been more influenced by evolutionary processes and have acquired more diversity.
Isolation and Characterization of Prophylactic Antimalarial Agents from Ochna kibbiensis Leaves
Authors: Yusuf Amina Jega , Abdullahi Musa Ismail , Nasir Ibrahim , Yunusa Abdulmajeed , Alebiosu Celestina Oluranti , Muhammad Abubakar Alhaji
Published: October 2022

Ochna kibbiensis (Family: Ochnaceae) has been employed in ethnomedicine for the treatment of malaria, and inflammation among others. The aim of this study was to isolate and characterize prophylactic antimalarial agents from the leaves of O. kibbiensis against Plasmodium berghei, in vivo and in silico. The median lethal dose (LD50) of the methanol extract and its fractions (n-hexane, dichloromethane, ethylacetate and n-butanol) was determined according to Lorke’s method while the antimalarial effect of the extract and its fractions was investigated according to the method described by Peters prophylactic test using Chloroquine-sensitive Plasmodium berghei (NK65). All the extract/fractions exhibited LD50 values ≥ 5000 mg/kg with the exception of the n-butanol fraction (1702.94 mg/kg) which indicate that the plant is non-toxic. Dichloromethane fraction exhibited significant (p<0.05) and dose-dependent prophylactic effect with 47.62, 85.12 and 100.0 % prophylaxis (at 500, 250 & 125 mg/kg) while the least effect was observed by the n-butanol fraction with percentage prophylaxis of 64.29 and 76.19, respectively; the standard drug, pyrimethamine had 95.24 % prophylaxis. Based on the result obtained, dichloromethane fraction of O. kibbiensis was subjected to chromatographic purification which led to the isolation of a mixture of two compounds identified as stigmasterol and β-sitosterol by analysis of the NMR spectral data and comparison with existing literature; the compounds exhibited good binding affinities (- 5.129 and - 4.889 kcal/mol) against pfLDH and favorable ADMET profile. In conclusion, the leaf of O. kibbiensis have demonstrated a significant prophylactic antimalarial activity and the two known steroids (stigmasterol and β-sitosterol) isolated from the dichloromethane fraction for the first time.
A Time-series Metabolomic Analysis of SARS-CoV-2 Infection in a Ferret Model
Authors: Karpe Avinash V. , Nguyen Thao V. , Shah Rohan , Au Gough G. , McAuley Alexander J. , Marsh Glenn A. , Riddell Sarah , Vasan Seshadri S. , Beale David J.
Published: October 2022

The global threat of COVID-19 has led to the increasing use of metabolomics to study SARS-CoV-2 infection in humans and animals. Despite this, understanding SARS-CoV-2's metabolome during infection remains difficult and incomplete. Here, metabolic responses were characterized from sampled nasal washes collected from an asymptomatic ferret model (n = 20) at different time points before and after the SARS-CoV-2 challenge using an LC-MS-based metabolomics approach. Multivariate analysis of the nasal wash metabolome data resulted in several statistically significant features being observed. Despite no effects of gender or interaction between gender and time on the time course of SARS-CoV-2 infection, 16 metabolites were significantly different at every time point post-infection. Among these altered metabolites, the relative abundance of taurine was elevated post infection which could be an indication of hepatotoxicity, while the accumulation of sialic acids could indicate SARS-CoV-2 invasion. The pathway analysis identified several pathways influenced by SARS-CoV-2 infection. Of these, sugar, glycan, and amino acid metabolisms were the key altered pathways in the upper respiratory channel during infection. These findings provide some new insights into the progression of SARS-CoV-2 infection in ferrets at the metabolic level which could be useful for the development of early clinical diagnosis tools and new or repurposed drug therapies.
RNA Interference Pathways in Juglandaceae: Based on Gene Diversity, Evolution, and Functional Differentiation
Authors: Fang Yuanpeng , Wei Jianming , Huang Xin , Li Yunzhou , Pan Xuejun
Published: October 2022

RNA interference (RNAi) is one of the main mechanisms for disease resistance and small RNA production in plants. The main proteins involved in RNAi include Dicer-like (DCL), RNA-dependent RNA polymerase (RDR), double-stranded RNA-binding (DRB), and Argonaute (AGO). Juglandaceae contains a variety of important woody plants, and walnuts are one of the four major woody plant groups and one of the four major dried fruits in the world. To clarify the evolution and functional differentiation of RNAi-related proteins in the walnut (Juglans regia) genome, this study integrated various web resources from gene family acquisition to structural analysis and transcriptome data to correlate walnuts and their congeners. The walnut genome has 5 DCL, 13 RDR, 15 DRB and 15 AGO genes, similar genes encoding conserved protein structural domains and conserved motifs with similar subcellular localization. Walnut AGO proteins are classified into three classes and seven subclasses. The DCL is divided into four categories, while RDR is mainly divided into four categories, and DRB can be divided into six categories. The exception is that the copy number of walnut RDR1 is 9, in which seven RDR1 are distributed in clusters on chromosome 16. Purifying selection drove the formation of walnut genes, but protein classes were subjected to varying degrees of purifying selection. Additionally, these results showed some similarity in other plants of the walnut family. Moreover, different RNAi-related genes of walnut produced abundant selective expression in response to different tissues and stresses. In this study, DCL, RDR, DRB and AGO gene families were identified and analysed in the genome of the walnut family for the first time and preliminarily examined the evolution, structure and expression characteristics of these families to provide a preliminary basis for the evolution of the walnut RNAi pathway and breeding research.
Shaking Table Testing of Reinforced Concrete IMRF Structure
Authors: Hussain Sida , Shakeel Hamna , Ali Asif , Rizwan Muhammad , Ahmad Naveed
Published: October 2022

Multi-level shaking table tests were performed on 1:3 reduced scale two-story RC IMRF frames conforming to ACI-318-19. The exterior joints lacked shear reinforcement to assess the viability of the ACI model recommended for determining the design shear strength of the beam-column joint panel. The Northridge-1994 earthquake accelerogram was input to the frame for multi-level shaking table testing. Plastic hinges developed in beams under base input motion with a maximum acceleration equal to 0.40g. The exterior joints incurred extensive damage under base input motion with a maximum acceleration equal to 0.70g. The frame achieved displacement ductility and overstrength factors equal to 2.40 and 2.50 respectively. This gives a response modification factor equal to 6. The satisfactory performance of the frame is attributed to the high efficiency of the beam-column joint, which was confined by spandrel beams on two faces, and the high strength of the concrete. The inherent minimal confinement is sufficient to ensure good seismic behavior. The analysis confirmed overstrength equal to 1.58 for joint shear strength in comparison to the design strength determined using the ACI model. The data might serve as a reference for calibrating and validating numerical modeling techniques for performance evaluation, which are crucial in the context of performance-based engineering.