bluuebunny/crossref_metadata_2025 huggingface dataset:
Terapias complementarias para el control de los síntomas del tracto urinario inferior masculino: revisión sistemática
Authors: Mata Luciana Regina Ferreira da , Motter Paula Giuliana Rodrigues , Azevedo Cissa , Bernardes Mariana Ferreira Vaz Gontijo , Chianca Tânia Couto Machado , Vasques Christiane Inocêncio
Published: July 2022

Resumen Objetivo: evaluar la evidencia científica sobre la efectividad de las terapias complementarias para el control de los síntomas del tracto urinario inferior en la población masculina adulta y adulta mayor. Método: revisión sistemática desarrollada según la checklist PRISMA. La búsqueda se realizó en las bases de datos CINAHL, Embase, LILACS, PEDro, PubMed, Web of Science y Google Scholar. Resultados: se identificaron 585 registros y se seleccionaron 12 ensayos clínicos que cumplían con los criterios de inclusión. Los resultados que los estudios consideraron para analizar la efectividad de las terapias complementarias fueron cuestionarios validados que evaluaban la gravedad de los síntomas del tracto urinario inferior (sensación de vaciado incompleto de la vejiga, micción frecuente, flujo intermitente, flujo débil, dolor o dificultad para orinar, nicturia y urgencia) y parámetros urodinámicos. Los estudios analizaron las terapias complementarias fitoterapia (n=8) y electroacupuntura (n=4). Seis estudios relacionados con la fitoterapia demostraron significación estadística. La electroacupuntura demostró una mejoría significativa de los síntomas en dos estudios. Conclusión: la fitoterapia fue efectiva para controlar los síntomas de frecuencia, urgencia, nicturia, vaciado incompleto, intermitencia, flujo débil y esfuerzo para iniciar la micción. Para confirmar la efectividad de la electroacupuntura, aún es necesario que se realicen investigaciones con metodologías bien diseñadas para resolver las diferencias entre los estudios de esta revisión.
Melaleuca armillaris essential oil as an odor reducer in intestinal ostomy bags: a semi-experimental study
Authors: Marques Elisângela Cássia , Souza Diba Maria Sebba Tosta de , Vilela Flávio Fraga , Teixeira Manoel Araújo
Published: July 2022

ABSTRACT Objective: Evaluate the effect of essential oil in odor reduction for intestinal ostomy bags. Method: Primary study, semi-experimental, prospective clinical trial with quantitative approach. A product prepared with Melaleuca armillaris leaves was tested in ostomy pouches, with and without effluents, for adhesion and odor control. Instrument: Labeled Magnitude Scale. Results: Colostomized participants, with a mean age of 73 ± 14.94, predominantly males; and informal caregivers, with a mean age of 44 ± 8.98, predominantly females. In the visual evaluation of the oil, 100% of the participants perceived its adherence. Regarding the evaluation of effluent odor by the colostomized, five reported “strong odor” before oil use and, six reported “weak” odor after use (p = 0.005). Five informal caregivers reported “very strong” effluent odor before oil use; and one reported “weak” and nine reported “moderate” after use (p = 0.0025). Conclusion: There was a reduction in the odor of effluents in the ostomy pouches with the essential oil of Melaleuca armillaris at 10%. Application for patent registration in the Brazilian National Institute of Industrial Property (INPI) under no. BR 10 2020 026987 9.
Children wearing face masks to prevent communicable diseases: scoping review
Authors: Braga Patrícia Pinto , Souza Meriele Sabrina de , Oliveira Patrícia Peres de , Romano Márcia Christina Caetano , Rocha Gustavo Machado , Gesteira Elaine Cristina Rodrigues
Published: July 2022

ABSTRACT Objective: To identify and synthesize scientific evidence that the use of face protection masks by children, in the community and at home, is a way of preventing communicable diseases. Data source: A scoping review was made using the Joana Briggs Institute method and PRISMA-ScR. A research was carried out in five electronic databases, at the Cochrane Library and on seven websites of governmental and non-governmental institutions. The data were organized in a spreadsheet and submitted to narrative analysis. Data synthesis: Initially, 658 productions were identified, of which 19 made up the final sample. Studies with higher levels of evidence are scarce. The types of masks identified were professional (surgical and facial respirators with filtration) and non-professional (homemade). The transmissible agents studied were influenza and SARS-CoV-2 viruses, and the evaluated environments were schools, homes and community spaces. The main discomforts reported were heat, shortness of breath, headache and maladjustment to the face. The indication and acceptability of masks change according to the age group and clinical conditions. There is no consensus on the reduction in the transmissibility of infections. Conclusions: Children older than five can benefit from the correct use of masks, as long as they are supervised, taught and educated to do so and the masks should be well adjusted to the face. The use of masks show better results when associated with other measures such as physical distancing, keeping places ventilated and frequent hand hygiene.
Time use in elderly people at the low active aging level: a qualitative study
Authors: Punyakaew Autchariya , Lersilp Suchitporn , Putthinoi Supawadee , Hsu Hsiu-Yun
Published: July 2022

Abstract Introduction Thailand's population is aging rapidly. Thus, it is necessary to enable elderly people to be independent and actively participate in daily occupations. Objective To describe the time used by elderly people at the low active aging level in a suburban village, in Chiang Mai, northern Thailand. Method The study was qualitative research, using the narrative interview method. Three case studies on the low level of active aging were collected by following an interview-based guideline. The data were analyzed using qualitative content analysis. Results The results showed that elderly people at the low active aging level spent their time in varied activities, depending on personal factors and their contexts. Elderly people participate in different occupations of everyday life, which consist of activities of daily living and self-care, the instrumental activities of daily living, leisure, and work. Conclusion It was found that elderly people spent their time in four main categories: Activities of daily living, Instrumental ADL, leisure, and work. Enabling elderly people to increase active aging by continuing engagement in social participation and education is still challenging.
Decomposing Changes in Higher Education Return on Investment Over Time
Authors: Webber Douglas
Published: July 2022

The economic returns to attending college are a crucial aspect of discussions surrounding student debt and rising tuition. As higher quality data on student outcomes has become available, studies have attempted to quantify the financial value of a college degree across different dimensions and contexts (Webber, 2014; Webber, 2016; Itzkowitz, 2021; Cooper, 2021; Miller and Akabas, 2022).
Young Borrowers' Usage of Cosigned Credit Cards and Long Run Outcomes
Authors: Case Hannah
Published: July 2022

In the United States, access to credit is an important channel for smoothing consumption and building wealth. However, establishing and building a credit history can take time. Parents may be able to help their children build credit early and ensure good credit behavior, such as paying on time, by being a cosigner on a credit card.
Analysis of the Digital Readiness and the Level of the ICT Development in Kazakhstan’s Regions
Authors:   Institute of Economics CS MES RK, Kireyeva A. A. , Satpayeva Z. T. ,   Institute of Economics CS MES RK, Urdabayev M. T. ,   Al-Farabi Kazakh National University
Published: July 2022

The level of digital readiness and the application of information and communication technologies (ICT) are key factors of any innovation policy. This research has highlighted the development of analysis of the degree of digital readiness and assessment methods of digital transformations, which can be used at various levels of business management to formulate digital transformation strategies. The present study investigates the theoretical framework in the field of innovation and spatial development considering the impact of the level of ICT. The research was conducted using index and economic-statistical methods based on a systematic approach. We developed a methodological tool adapted to the regional management level. The ICT development index, Krugman localisation index and Herfindahl-Hirschman index were modified to analyse digital readiness and ICT development at the regional level. The algorithm includes the following steps: assessment of the internet usage level; analysis of the degree of costs for the production of ICT; evaluation of the digital literacy rate of the population; evaluation of the degree of regional industry specialisation in the field of ICT. It was revealed that Kazakhstan’s regions have varying levels of ICT development, which is why they have different prerequisites and prospects for digitalising their economy. The agglomerations that could become “growth poles” of Kazakhstan’s knowledge-based economy were identified, such as Almaty city, Nur-Sultan city, Karaganda, and Aktobe regions. Government bodies can use the research findings for Kazakhstani territories’ digital modernisation.
Classification of Intersystem Accidents in Infrastructure-Complex Territories
Authors:   RUDN University, Lesnykh V. V. , Timofeeva T. B. ,   State University of Management
Published: July 2022

Urbanisation led to the establishment of infrastructure-complex territories (ICTs). The growing interaction between critical infrastructures in such territories, combined with an increase in the frequency and scale of natural disasters, caused a surge in intersystem accidents (ISA). ISAs are characterised by cascading processes and catastrophic consequences for regional socio-economic development, since they affect both the critical infrastructure and environment. The paper aims to classify intersystem accidents in infrastructure-complex territories, as well as to assess the adaptive resilience of these areas to external influences. An examination of available statistics on domestic and foreign intersystem accidents demonstrated the importance of the issue and allowed us to identify common features of ISAs. The research analysed various approaches to the classification of territories and their adaptive resilience to external influences, showing that the existing classifications mostly do not consider infrastructure-complex territories and the possibility of intersystem accidents. Based on the analysis of statistical data and simulation of cascade failures and emergencies, the article proposes a new approach to the classification of intersystem accidents in infrastructure-complex territories. The scale of economic and social consequences, location of the accident, structure of the development of emergency processes, and other classification features were used. The proposed classification will help simulate emergencies, develop methods for assessing the consequences and resistance of infrastructure-complex territories to external influences, and, subsequently, increase adaptive resilience and economic efficiency of regional development. Further research will be aimed at predicting the development of ISAs and assessing the resulting damage in accordance with the proposed classification.
Modelling Crop Yield in Agricultural Regions Using Computer Vision Technology
Authors:   National Research University “Higher School of Economics”, Arkhipova M. Yu.
Published: July 2022

The article examines new methodologies for modelling crop yield in agricultural regions of Russia based on the use of remote capabilities to get information on the field state. The proposed approach can be applied to develop indicator systems and create methodological platforms and models necessary to obtain more accurate estimates. In comparison with the traditional regression model, this method uses computer vision technology to gather additional data. Statistical hypothesis testing confirmed the significance of satellite photographs of fields for improving the accuracy of crop yield forecasting models. Traditional econometric tools were compared with various neural networks in order to discover the optimal model. The proposed tools were tested using data from 100 agricultural fields located in municipalities of 43 Russian regions, selected in proportion to the volume of crop production in this region. The conducted analysis showed the advantage of the mixed data neural network in comparison with other neural (multilayer perceptron and convolutional neural network) and regression models. In conditions of uncertainty and a large amount of data, the mixed data neural network can help obtain more accurate estimates. Additionally, while environmental factors have different effects on crop yields, they must be considered along with socio-economic characteristics. The use of new models and data types differing from table information can significantly improve the forecasting accuracy and interpretation. The analysis results can be used for examining and monitoring agricultural production in regional municipalities, determining farm resource requirements, as well as for creating sectoral and comprehensive projects and programmes for the development of the agricultural industry.
[RETRACTED] Via Nature CBD Gummies (PAIN RELIEF) Real Breakthrough Results? v1
Authors: H H
Published: July 2022

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[RETRACTED] Keto Complete Australia {AU/UK} Pills Reviews! v1
Authors: not provided keto-x-reviews
Published: July 2022

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Keto Complete AU Reviews
[RETRACTED] Neuro Lift Brain Cognition Formula ALERT Before Buy Ingredients Benefits Price Offers(REAL OR HOAX) v1
Authors: Lift Brain Cognition Formula Neuro
Published: July 2022

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[RETRACTED] Arctos Portable AC Reviews- Price or Does it Really Work? v1
Authors: not provided health
Published: July 2022

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Arctos Portable AC is natural product which has no side effects. Read about scam, price reviews, and where to get.
[RETRACTED] Fit Today Keto v1
Authors: Today Keto Fit
Published: July 2022

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[RETRACTED] Uly Keto CBD GummiesReviews – Complete Ripoff or Keto Pills That Work? Real Scam Complaints or Legit Diet Pills? v1
Authors: CBD Gummies Uly
Published: July 2022

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[RETRACTED] Neuro Lift Brain Cognition Formula– World #1 Supplement | Its Really Works? v1
Authors: not provided neuroliftbrain
Published: July 2022

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Neuro Lift Brain is a dietary supplement from the UK which is said to increase concentration and memory (the website says ‘brain function’). Please read the comments at the bottom of the page and our opinion on Neuro Lift Brain.
[RETRACTED] Keanu Reeves CBD GummiesTHE MOST POPULAR CBD GUMMY BEARS IN UNITED STATES READ HERE REVIEWS, BENEFITS, SIDE EFFECT, INGREDIENTS, DOES IT REALLY WORK? IS IT SAFE? BUY NOW GET INSTANTLY v1
Authors: Reeves keanu
Published: July 2022

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[RETRACTED] Results of Mighty Keto Gummies - Is Mighty Keto Gummies Safe? v1
Authors: not provided Geminiketoe
Published: July 2022

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[RETRACTED] K1 Keto Life Reviews 2022 - 100% Most Shocking All Natural Ingredients That Works! Don’t Buy Fast Until You Read This Latest Report v1
Authors: not provided health
Published: July 2022

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K1 Keto Life Reviews {Warnings}: Scam, Side Effects, Does It Work?
[RETRACTED] Total Health ACV + Keto Gummies - Warning! Don’t Buy Until You Read This! v1
Authors: A H
Published: July 2022

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[RETRACTED] Ntx Nutrition Keto Gummies [ITS HYPE or WORTH] See the Truth Exposed! v1
Authors: G G
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[RETRACTED] Uly Keto CBD Gummies: Negative Reviews, Bad Complaints & Side Effects?Pills Advanced BHB Boost Ketogenic Supplement Exogenous Ketones for Men Women 60 Capsules 2 Bottles v1
Authors: CBD Gummies Uly
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[RETRACTED] Natures Hub Anti Aging Skin Cream Your Skin With Natural Ingredients NEW! v1
Authors: not provided yseultbisson
Published: July 2022

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NGS library preparation usingNEXTFLEX Rapid Directional RNAseq kit (NOVA-5138-08) for animal tissue samples v1
Authors: Li Yiqiao
Published: July 2022

This protocol is used for successful NGS library preparation from total RNA of animal tissue samples. This method is mainly optimised to obtain full-length hepacivirus genomes using the Illumina NGS sequencing platform, but it also can be used for sequencing any other RNA virus originating from tissue samples.
DNA extraction (BOMB_Soil) v1
Authors: Hung Tsu-Chun
Published: July 2022

DNA extraction (BOMB_Soil)
Evaluation of Vitamin B12 Levels in Pregnant Population and Relationship with Nutritional Deficiency
Authors: BEYOĞLU Muhammed Mustafa , KÖSTÜ Bülent
Published: July 2022

AbstractObjective: This study aims to examine the level of vitamin B12 according to trimesters in the pregnant population, to investigate its relationship with malnutrition in cases of insufficiency and deficiency, and to start supplementation with early diagnosis.Material and Methods: Sociodemographic survey data, ultrasonography data, hemogram, biochemistry and vitamin B12 levels of pregnant women who applied to the department of obstetrics and gynecology of a reginal university hospital were examined. SPSS 22.0 statistics program was used to evaluate the data. P<0.05 was considered significant.Results: Two hundred and fifty pregnant women were included in our study. The mean age was 26.42±5.86 (18-40 years). The mean vitamin B12 level of the participants was 214.45±83.99 ng/ml (80-656). According to the postoc duncan test, the vitamin B12 levels of the participants showed a significant difference with the 1st trimester 2 and 3 (p<0.05), while the 2nd and 3rd trimesters did not show a significant difference in themselves (p=0.968). When compared according to socioeconomic levels, vitamin B12 levels of the group with a monthly income of 3001 turkish lira and above was found to be 228.336±63.665 ng/ml,and the group with a monthly income of 3000 turkish lira and below was 199.016±45.630 ng/ml. There was a significant difference between the two groups (p<0.05). Considering the relationship between vitamin B12 levels and nutritional deficiency, vitamin B12 levels were found 268.27±86.96 ng/ml in the group consuming full and/or half servings of animal food daily, and 166.34±41.60 ng/ml in those consuming and/or not consuming a quarter serving. When the two groups were compared with each other, a significant difference was found (p<0.05).Conclusion: Vitamin and mineral balance during pregnancy is very important for maternal and fetal health. Vitamin B12 deficiency and/or insufficiency are in considerable numbers. When necessary, the individual should be trained in terms of proper nutrition immediately with early diagnosis. Supportive treatment from folic acid-vitamin B12 combined drugs should be considered in essential cases according to the profit-loss ratio.
Fomentando la competencia intercultural en el aula universitaria: trabajando la empatía histórica a través de the thing around your neck, de Chimamanda Ngozi Adichie”
Authors: Perales Fernández de Gamboa Andrea , Apaolaza-Llorente Dorleta , Orcasitas-Vicandi María
Published: July 2022

La empatía histórica se define como el proceso de compromiso cognitivo y afectivo que los estudiantes adquieren con las figuras históricas para comprender sus experiencias, toma de decisiones y acciones. La empatía histórica implica el entendimiento de cómo las personas, en el pasado, pensaban, sentían, decidían, actuaban y afrontaban las consecuencias dentro de un contexto histórico y social específico. Esta es una herramienta fundamental para el cambio de paradigma en la enseñanza histórica conectando tres procesos: la contextualización histórica, la toma de perspectiva y la conexión afectiva. Así, la propuesta que presentamos tiene dos objetivos:  trabajar la empatía histórica desde la literatura, enfoque novedoso y único, y trabajarla en un aula universitaria. Consideramos que, debido a la exclusión que tradicionalmente han sufrido las mujeres, su literatura es la más pertinente para desarrollar esta propuesta. Por ello, utilizaremos el cuento “A Private Experience”, de Chimamanda Ngozi Adichie, incluído en The Thing Around Your Neck.
Aprendizaje cooperativo en tiempos de pandemia. implementación de la técnica compleja «grupos de investigación» a través de un proceso de investigación-acción
Authors: Navarro Moreno Adriana , Sanahuja Ribés Aida
Published: July 2022

La pandemia ocasionada por la COVID-19 ha generado nuevos desafíos en el ámbito educativo. Uno de ellos se centra en la implementación de prácticas que requieren de interacción entre los iguales, como el aprendizaje cooperativo. El objetivo de este estudio es mostrar como se ha implementado una práctica educativa centrada en el aprendizaje cooperativo en tiempos de pandemia siguiendo un proceso de investigación-acción. Así pues, este estudio se enmarca en una investigación educativa siguiendo un diseño y un método cualitativo. Han participado 18 estudiantes de un aula de 4º de educación primaria, 4 docentes y una observadora participante. La recogida de datos se ha efectuado a través de entrevistas, la observación participante y técnicas de diagnóstico social participativo (línea del tiempo, Felicito-critico-propongo y la rueda socrática). A partir de los resultados obtenidos se extraen algunos elementos que ayudan a materializar prácticas de aprendizaje cooperativo en tiempos de pandemia.
Application of the Model of Potential Containers for Packing Complex Shape Objects
Authors:   Moscow State University of Technology STANKIN, Moscow, 127055, Russian Federation, Chekanin V. A. ,   V. A. Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, Moscow, 117997, Russian Federation, Chekanin A. V. ,   Moscow State University of Technology STANKIN, Moscow, 127055, Russian Federation
Published: July 2022

The optimization problem of packing objects of arbitrary shape with generalization in dimension is considered. The purpose of this work is to develop and study algorithms that provide fast optimized placement of a large number of objects of arbitrary shape. To achieve this goal, the problem was set to improve the model of potential containers, originally developed for packing orthogonal objects in the form of rectangles or parallelepipeds. To quickly get layouts, it is proposed to switch from a polygonal representation of objects under placing to their discrete representation after voxelization. Obviously, when placing objects of complex shape are voxelized with a high degree of detail, a large number of potential containers will be formed, which will reduce the speed of solving the problem. This article presents the developed algorithms optimized by the number of potential containers processed to increase the speed of geometric design of a layout. Computational experiments have shown that the highest speed of the formation placement schemes of orthogonal polyhedrons is provided by using algorithms based on the application of the set-theoretic intersection operation. A method of removing unused potential containers is proposed, which allows several times to increase the speed of object placement. It is shown that the effectiveness of its application increases with an increase in the number of objects to be placed. A method for creating a container of complex shape form a polygonal model by applying an orthogonal polyhedron of geometric constraints to it is presented. All presented algorithms are implemented programmatically for the case of an arbitrary dimension of the problem being solved.
Implementation and Analysis of Combined Machine Learning Method for Intrusion Detection System
Authors: Masduki Bisyron Wahyudi , Ramli Kalamullah , Murfi Hendri
Published: July 2022

As one of the security components in Network Security Monitoring System, Intrusion Detection System (IDS) is implemented by many organizations in their networks to detect and address the impact of network attacks. There are many machine-learning methods that have been widely developed and applied in the IDS. Selection of appropriate methods is necessary to improve the detection accuracy in the application of machine-learning in IDS. In this research we proposed an IDS that we developed based on machine learning approach. We use 28 features subset without content features of  Knowledge Data Discovery (KDD) dataset to build machine learning model. From our analysis and experiment we get 28 features subset of KDD dataset that are most likely to be applied for the IDS in the real network. The machine learning model based on this 28 features subset obtained 99.9% accuracy for both two-class and multiclass classification. From our experiments using the IDS we have developed show good performance in detecting attacks on real networks.
Assisted Navigation Algorithm for Wireless Sensor Actuator and Robot Networks
Authors: Frattolillo Franco
Published: July 2022

Wireless Sensor, Actuator and Robot Networks (WSARNs) are made of mobile and static sensor nodes that interact in order to collaboratively perform specific tasks, such as supporting assisted navigation for mobile robotic nodes that carry out requested operations in hostile environments, where the human presence is impracticable. In this regard, it is worth noting that assisted navigation algorithms have a highly dynamic nature, and are implemented by sensor nodes that are characterized by limited transmission power and lean autonomy in terms of computing and memory capacity. This paper presents an improved version of the assisted navigation algorithm based on the concept of “credit field”. The main aim of the proposed algorithm is to reduce and balance the energy consumption among the static sensor nodes when running the algorithm to manage the presence of obstacles and adversary areas, thus extending the lifetime of WSARNs. The algorithm has been tested on a hybrid sensor network that employs Mica2 Motes as static sensor nodes and Lego Mindstorms robots integrated with a Stargate board developed by Crossbow as mobile nodes.
A New Distributed Intrusion Detection System Based on Multi-Agent System for Cloud Environment
Authors: ACHBAROU Omar
Published: July 2022

Cloud computing, like any distributed computing system, is continually exposed to many threats and attacks of various origins. Thus, cloud security is now a very important concern for both providers and users. Intrusion detection systems (IDSs) are used to detect attacks in this environment. The goal of security administrators (for both customers and providers) is to prevent and detect attacks while avoiding disruption of the smooth operation of the cloud. Making IDSs efficient is not an easy task in a distributed environment such as the cloud. This problem remains open, and to our knowledge, there are no satisfactory solutions for the automated evaluation and analysis of cloud security. The features of the multi-agent system paradigm, such as adaptability, collaboration, and distribution, make it possible to handle this evolution of cloud computing in an efficient and controlled manner. As a result, multi-agent systems are well suited to the effective management of cloud security. In this paper, we propose an efficient, reliable and secure distributed IDS (DIDS) based on a multi-agent approach to identify and prevent new and complex malicious attacks in this environment. Moreover, some experiments were conducted to evaluate the performance of our model.
Рossibilities of comprehensive correction of malnutrition in spinal cord injured patients
Authors: Gumarova Lyaysyan Sh. , Bodrova Rezeda A. , Akhmetzianova Gulisa Z.
Published: July 2022

BACKGROUND: Medical rehabilitation of spinal cord injured patients is an important medical and social problem associated with the high level of disability in this patient category.
AIM: This study aims to improve the efficiency of medical rehabilitation of spinal cord injured patients based on a set of measures of nutritional support and raising the exercise tolerance.
MATERIALS AND METHODS: A total of 78 patients in the intermediate recovery period of spinal cord injury were monitored, and their nutritional status was evaluated in the dynamics. In the first (main) group, a complex correction of the nutritional status with additional use of high protein hypercaloric mixtures for enteral nutrition was performed before and after hand cycling. In the second (control) group, the rehabilitation techniques were performed on the generally accepted basis.
RESULTS: As a result of the complex correction, the proportion of patients with mild and moderate malnutrition was significantly lower in the first (main) group than that in the second (control) group (p=0.05). Peak oxygen consumption increased in the first group of patients with mild malnutrition on 34.1% (p=0.019) and with moderate malnutrition on 23.6% (p=0.02) compared to that in the control group. All spinal cord injured patients of the first (main) group were found to have improved their motor and social activity according to the FIM scale compared to that in the control group (p 0.001).
CONCLUSIONS: Combining adequate nutritional support and proper handcycling significantly contributes to reducing malnutrition in patients with spinal cord injury (p=0.05). Tolerance to physical exercises during the complex correction of malnutrition significantly increased (p 0.01) as well as the motor and social activities and, therefore, the quality of life (p 0.0001).
Connective tissue dysplasia in surgery
Authors: Styazhkina Svetlana N. , Capustin Boris B. , Malchicov Arcady Ya. , Chernyshova Tatiana E. , Kononova Natalia Yu. , Usachev Anton V. , Shisterova Elena V.
Published: July 2022

Objective. To identify the features of connective tissue dysplasia in patients undergoing treatment in the Surgical Unit of the First Republican Clinical Hospital of Izhevsk.
Materials and methods. The study of connective tissue pathology was conducted in patients with surgical diseases on the basis of the Surgical Unit of the "First Republican Clinical Hospital of the Ministry of Healthcare of the Udmurt Republic".
Results. The following phenotypic manifestations of connective tissue dysplasia were revealed in the examined patients: asthenic type of constitution; body weight deficiency; dolichostenomelia; arachnodactyly; deformities of the chest and spine; joint mobility; atrophic striae, skin hyperextension; longitudinal and transverse flat feet; ventral and inguinal hernias; varicose veins.
Conclusions. Thus, the variety of clinical symptoms in connective tissue pathology indicates the systemic nature of the lesion since connective tissue is located in almost all organs and systems and has a number of important functions. In its turn, underestimating the importance of connective tissue dysplasia leads to the development of severe complications, which require early diagnosis, timely prevention, and, if necessary, adequate complex therapy and rehabilitation of patients with this syndrome.
Jurisdictional and Non-jurisdictional Forms of Patent Rights Protection: Russian and Foreign Experience
Authors: Diakonova Maria O. , Pechegina Polina D.
Published: July 2022

The features of patent disputes determine the variety of mechanisms for their consideration and resolution. A review of the Russian and foreign experiences (Germany, Norway, United States, France, Sweden, Japan) show the applicability of various forms of patent rights protection, including administrative and judicial.

Administrative bodies that protect patent rights generally include divisions of patent offices and other executive authorities.

In the judicial systems of the states under review, special judicial structures function in the nature of courts with general competence to consider civil cases, while specialized courts for the protection of intellectual property rights including patents have been created.

The authors conclude that in the modern period, the arbitration and mediation of patent disputes are becoming increasingly widespread, offering a number of advantages, including confidentiality of the case and the necessary level of specialization of arbitrators (mediators). At the same time, however, it is hindered by the lack of uniformity in resolving the issue of the arbitrability of patent disputes.
Federal guidelines on diagnosis and treatment of bronchial asthma
Authors: Chuchalin A. G. , Avdeev S. N. , Aisanov Z. R. , Belevskiy A. S. , Vasil’eva O. S. , Geppe N. A. , Ignatova G. L. , Knyazheskaya N. P. , Malakhov A. B. , Meshcheryakova N. I. , Nenasheva N. M. , Fassakhov R. S. , Khaitov R. M. , Il’ina N. I. , Kurbacheva O. M. , Astafieva N. G. , Demko I. V. , Fomina D. S. , Namazova-Baranova L. S. , Baranov A. A. , Vishneva E. A. , Novik G. A.
Published: July 2022

Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and a personalized approach to therapy. At the same time, despite a wide range of therapeutic options, many patients with asthma cannot achieve control over the disease.

Methodology. The target audience of these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmonologists, and functional diagnostics doctors. Each thesis-recommendation about diagnostic and therapeutic procedures has been scored according to the scales of classes of recommendations from 1 to 5 and A, B, C scale of the levels of evidence. The clinical recommendations also contain comments and explanations to the theses, algorithms for the diagnosis and treatment of bronchial asthma, and reference materials.

Conclusion. The presented clinical guidelines cover current information about the etiology and pathogenesis, classification, clinical manifestations, diagnosis, treatment, and prevention of bronchial asthma. These guidelines were approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation in 2021.
YÜKSEK YAĞLI DİYET / STREPTOZOTOSİN İLE İNDÜKLENEN DİYABETİK FARELERDE METFORMİNİN HEPATORENAL HASARA KARŞI KORUYUCU ETKİLERİ
Authors: Doğanay Songül , Budak Özcan , Bahtiyar Nurten , Toprak Veysel
Published: July 2022

AMAÇ: Sunulan bu çalışmada yüksek yağlı diyet ve streptozotosin ile deneysel tip 2 diyabet oluşturulan farelerde metformin tedavisinin karaciğer ve böbrek dokularında antioksidan etkisinin araştırılması amaçlandı.GEREÇ VE YÖNTEM: Yirmi bir adet yetişkin (11-12 haftalık 15-18 g) C57BL6 erkek fare rastgele üç gruba ayrıldı; Kontrol grubu (K), Diyabet grubu (D), ve Diyabet+Metformin tedavi grubu (D+MTF). D ve D+MTF grupları 4 hafta süreyle yağ oranı %60 olan yüksek yağlı diyetle beslendi. 4. Haftanın sonunda 30 mg/kg tek doz streptozotosin intraperitoneal uygulanarak tip 2 diyabet oluşturuldu. Metformin 300 mg/kg/gün dozunda gavaj ile verildi. Deney sonunda alınan karaciğer ve böbrek örneklerinde; glutatyon (GSH), katalaz (KAT) ve malondialdehit (MDA) düzeyleri spektrofotometrik yöntemle ölçüldü. Hemotoksilen ve Eozin ile boyanan doku kesitleri histomorfolojik olarak değerlendirildi.BULGULAR: Çalışma sonuçları diyabetik hayvanların karaciğer ve böbrek dokularında MDA düzeylerinin arttığını gösterdi. Metformin tedavisinin her iki dokuda da MDA düzeylerini azaltıp, GSH ve KAT düzeylerini artırdığı ancak bu artışın karaciğerde anlamlı düzeyde olmadığı (p>0,05), böbrekte ise anlamlı düzeyde olduğu bulundu (p<0,05). Ayrıca Histopatolojik değerlendirme sonuçlarında D+MTF grubunda nadir alanlarda vakuolizasyon, yer yer nekroz ve sinozoidal tıkanıklık görülürken, D grubu karaciğerlerinde yoğun vakuolizasyon, yüksek oranda sinozoidal tıkanıklık ve nekroz görüldü. Böbrek dokusunda K grubunda tübüler yapının normal yapıda olduğu; D grubunda, tübüllerin genişlediği ve yoğun kanama alanlarının olduğu; D+MTF grubunda ise nadir alanlarda tübül yapılarında vakuollerin olduğu görüldü.SONUÇ: Bu çalışmanın sonuçları, Diyabette dokularda oksidatif stresin oluştuğunu, metformin tedavisinin diyabette artan oksidatif stres üzerinde düzeltici etki göstererek dokularda hasar oluşmasını engellediğini göstermektedir.
FİBROMİYALJİ TEDAVİSİ ALAN HASTALARDA 25-HİDROKSİ VİTAMİN D DÜZEYLERİNİN DEĞERLENDİRİLMESİ
Authors: Düğeroğlu Harun
Published: July 2022

AMAÇ: Bu çalışma ile fibromiyalji tedavisi alan hastalarda 25-hidroksi vitamin D (25(OH)D) düzeylerinin değerlendirilmesi amaçlandı.GEREÇ VE YÖNTEM: Çalışmada Ocak 2018 - Mart 2020 tarihleri arasında hastanemizde diğer sistemik hastalıklar ekarte edilerek, ACR (American College of Rheumatolog) 2010 tanı kriterlerine göre fibromiyalji tanısı konulan ve tedavi alan 18 yaş ve üstü 244 hastanın verileri ile kontrol grubu olarak 120 hastanın verileri retrospektif olarak tarandı. Fibromiyalji tedavisi alan hastalar ve kontrol grubu hastalar serum 25-hidroksi vitamin D düzeylerine göre üç gruba ayrıldı (eksik, yetersiz ve normal). Gruplar arasında istatistiksel olarak anlamlı bir fark olup olmadığı analiz edildi. Ayrıca, hasta grubunun vitamin D düzeyleri, yaş aralıklarına göre değerlendirilmesi yapıldı. P değeri 0.05’den küçük olması anlamlı kabul edildi.BULGULAR: Çalışmaya alınan 244 fibromiyalji tanılı hastanın % 66,4 (n=162)’ü kadın, %33,6 (n=82)’ı erkek idi. Hasta grubunun ortalama serum 25(OH)D düzeyi 16,2±12,7 ng/ml olarak hesaplandı. Kontrol grubu olarak alınan 120 hastanın ise, %70 (n=84)’i kadın, %30 (n=36)’u erkek idi. Kontrol grubunun ortalama serum 25(OH)D düzeyi ise 24,6±13,1 ng/ml olarak hesaplandı. Fibromiyalji tedavisi alan hasta grubu ile kontrol grubu hastalarının cinsiyetleri ile serum 25(OH)D düzeylerinin istatistiksel olarak karşılaştırılması yapıldığında, gruplar arasında anlamlı fark bulundu (p=0.017). Ayrıca, hasta grubunda en düşük serum 25(OH)D düzeyini 36-50 yaş aralığında saptadık.SONUÇ: Fibromiyalji tedavisi alan hastalarda yüksek oranda vitamin D eksikliği ve yetersizliği görülmektedir. Bu nedenle, vitamin D seviyesi düşük olan hastalara yeterli düzeyde replasman yapılmasının hastaların kas-iskelet sistemi semptomlarında ve şikayetlerinde belirgin azalma sağlayacaktır.
ERİŞKİN HASTALARDA TONSİLLEKTOMİ SONRASI GÖRÜLEN KANAMALARIN RETROSPEKTİF ANALİZİ
Authors: Çevik İsmail , Yücedağ Fatih , Sevil Ergün
Published: July 2022

AMAÇ: Bu çalışmada tonsillektomi sonrası kanayan hastaların özelliklerini belirlemek ve bu hastalara yaklaşımlarımızı araştırmak amaçlanmıştır.GEREÇ VE YÖNTEM: Bu çalışmamızda tonsillektomi sonrası kanama ile kliniğimize başvuran 29 hastanın kayıtları geriye dönük incelendi. Hastaların yaş, cinsiyet, ameliyattan sonra kaçıncı gün kanadığı, laboratuvar parametreleri, kanama sebepleri, uygulanan cerrahi teknik ve kanama müdahale yöntemleri araştırıldı.BULGULAR: Hastaların 11 (%37,9)’i kadın, 18 (%62,06)’i erkek olup yaş ortalaması 26,8 (18-45) yıl idi. 25 hastaya soğuk bıçak yöntemi ile, 4 hastaya ise bipolar koter yardımı ile tonsillektomi yapıldı. Ameliyattan sonra kanama nedeni ile ortalama başvuru süresi 7,3 (1-19) gün idi. Altı (%20,6) hastada kanama nedeni tespit edilebildi. İki hastaya konservatif tedavi yöntemleri uygulandı, hastaların 14’üne (%48,2) lokal, 13’üne (%44,8) ise genel anestezi altında kanama müdahalesi yapıldı.SONUÇ: Tonsillektomi sonrası kanamalara erişkin hastalarda sık rastlanmakta ve bu durum hayatı tehdit edici sonuçlar doğurmaktadır. Yeni tedavi yöntemleri ve kanama sonrası erken müdahale ile olası komplikasyonların önüne geçilebilir.
Movida Fit! Un programa extraescolar de actividad física basada en la metodología HIIT para prevenir la obesidad y mejorar la forma física y el rendimiento académico
Authors:   Universidad de Castilla-La Mancha, Ruiz-Hermosa Abel , Sánchez-López Mairena , Martínez-Vizcaíno Vicente , Redondo-Tévar Andrés
Published: July 2022

Son muchos los estudios que han puesto de manifiesto los numerosos beneficios que la actividad física tiene sobre la salud física, psíquica y social en la infancia. Sin embargo, los niveles de inactividad física y sedentarismo en niños y niñas han aumentado significativamente en los últimos años, conduciendo a un aumento de la obesidad infantil y de enfermedades cardiovasculares. Con el objetivo de prevenir este problema de salud pública surgen los programas de promoción de actividad física en el entorno escolar MOVI. La última edición que el grupo del Centro de Estudios Sociosanitarios ha llevado a cabo analiza la efectividad de un programa de actividad física extraescolar (MOVI-da FIT!) basada en el entrenamiento a intervalos de alta intensidad (high intensity interval training -HIIT- por sus siglas en inglés) para mejorar la función ejecutiva, el rendimiento académico, la forma física y reducir la adiposidad y el riesgo cardiometabólico de los escolares. El presente libro va dirigido a profesionales de la educación, de la salud y de las ciencias de la actividad física y del deporte interesados en desarrollar y llevar a cabo intervenciones de actividad física destinadas a la prevención de la obesidad, la mejora de la forma física, el rendimiento cognitivo y académico de los escolares. En la primera parte, se describen los antecedentes y el estado actual del conocimiento que justifica este estudio. Además, se detallan los objetivos y la metodología utilizada en el mismo. En la segunda parte, se especifican las características del programa MOVI-da FIT!, y se detallan 50 de las sesiones utilizadas en el programa de forma reproducible, de tal forma que puedan ser de utilidad para cualquier profesional interesado en llevar a cabo intervenciones extraescolares de AF recreativa no competitiva.
Indicadores da educação superior e os desafios para o estado de Rondônia
Authors: Moreira Denilson Nunes , Moreira Elisete Maria da Silva , Araujo Elvira Aparecida Simões de
Published: July 2022

A pesquisa teve como objetivo a compressão do processo educacional no ensino superior no Estado de Rondônia. Utilizou-se a pesquisa qualitativa junto aos indicadores educacionais do Ministério da Educação (MEC), Instituto Brasileiro de Geografia e Estatística (IBGE) e do Atlas do Desenvolvimento Humano (ATLAS). Rondônia por estar localizada na região amazônica e distante dos grandes centros industriais e tecnológicos do Brasil, experimentou um desenvolvimento cíclico instável, baseados no extrativismo mineral e vegetal desde a sua fundação no ano de 1914. O ensino superior teve inicio no ano de 1973, quando do convênio entre a (UFRGS) e o Território Federal de Rondônia no desenvolvimento dos primeiros cursos de graduação. No ano de 1982 quando do surgimento do Estado criou-se a Fundação Universidade Federal de Rondônia, período em que se inicia a expansão da educação superior. Dados do MEC (2018) descrevem que existam hoje 42 instituições de ensino superior, sendo 40 instituições nas redes privadas como faculdades e centros universitários e 01 universidade federal e 01 Instituto Federal de Educação no segmento público. Rondônia de acordo com o MEC possui ainda 318 cursos de graduação presencial nas redes públicas e privadas distribuídas em seus 52 municípios. Desta forma conclui-se que o Estado possui um potencial para continuar a crescer, sendo uma das alternativas a educação superior na formação e capacitação de mão de obra qualificada ao setor produtivo e o ensino, a pesquisa e a extensão, possibilitando um crescimento sustentável em beneficio da sociedade.
Análise da perspectiva sobre a contextualização no ensino de química e a ruptura com o paradigma positivista
Authors: Órfão Luciano Gomes , Alvim Márcia Helena
Published: July 2022

Neste artigo, de cunho teórico, buscamos analisar as diferentes possiblidades de compreensão da perspectiva sobre a contextualização do ensino de química, através de discussão bibliográfica e estudo de normativas sobre a formação de professores de química, valorizando a concepção que promove uma ruptura com o paradigma positivista a partir da crítica sociológica ao mesmo, através de autores como Boaventura de Sousa Santos e Edgar Morin. O objetivo do artigo consiste na análise da perspectiva sobre a contextualização do ensino como instrumento na promoção de um ensino de ciências crítico e problematizador. Após a reflexão teórica, iremos analisar as normativas para a formação docente em Química, dentre elas os Parâmetros Curriculares Nacionais do Ensino Médio (1999), as Diretrizes Curriculares Nacionais para os cursos de Química (2001) e as Diretrizes Curriculares Nacionais para a Formação Inicial em Nível Superior e para a Formação Continuada (2015), com o objetivo de compreender como a perspectiva da contextualização do conhecimento científico é promovida nestas legislações. A metodologia desenvolvida nesta pesquisa caracteriza-se pela abordagem qualitativa, a partir da análise crítica do conceito de contextualização em referenciais teóricos e normativas sobre formação de professores de Química. Como resultado identificamos que os referenciais teóricos e os documentos analisados assumem a importância da promoção de um ensino de química contextualizado, a partir da contextualização que favorece a formação de um cidadão crítico através de uma educação científica problematizadora, a qual valoriza os aspectos sociais, políticos, econômicos e culturais para a compreensão do processo científico.
Jogos didáticos no ensino de botânica: uma abordagem lúdica desenvolvida na monitoria acadêmica
Authors: Barros Karen Pereira , De Paiva Aparecida Barbosa , Sousa Adervan Fernandes , Sudério Fabrício Bonfim
Published: July 2022

A monitoria acadêmica pode contribuir para que a abordagem dos conteúdos de botânica seja feita de maneira lúdica e criativa. Assim, o objetivo geral dessa pesquisa foi apresentar os resultados de uma intervenção que envolveu a aplicação de dois jogos didáticos como metodologia de ensino complementar durante a monitoria da disciplina de Morfologia e Taxonomia de Criptógamas. Essa pesquisa é de natureza qualitativa e descritiva, envolvendo estudantes do Curso de Licenciatura em Ciências biológicas da FAEC/UECE. O primeiro jogo utilizado na pesquisa envolveu os conteúdos de briófitas (jogo de tabuleiro), enquanto o segundo abordou os conteúdos de pteridófitas (jogo de palavras cruzadas). A aplicação dos mesmos ocorreu como forma de revisão, seguida de um questionário avaliativo sobre a opinião dos discentes acerca do jogo enquanto estratégia pedagógica de ensino e sobre os jogos específicos utilizados na pesquisa. Os participantes demonstraram ter uma visão positiva quanto à utilização dos jogos didáticos no ensino superior e consideraram que os jogos aplicados nesse trabalho contribuíram para as suas formações acadêmicas, funcionando como um eficiente mecanismo de abordagem dos conteúdos de briófitas e pteridófitas. Para a estudante que atuou como monitora, o desenvolvimento da pesquisa permitiu que a mesma pudesse refletir sobre a ação docente planejada, promovendo o seu desenvolvimento profissional e um novo olhar em relação ao processo de ensino e aprendizagem. Conclui-se que ficou evidente para os estudantes a significância e a contribuição dos jogos didáticos podem oferecer para uma melhor compreensão dos conteúdos explorados na pesquisa.