bluuebunny/crossref_metadata_2025 huggingface dataset:
A Strontium and Hydro-Geochemical Perspective on Human Impacted Tributary of the Mekong River Basin: Sources Identification, Fluxes, and CO2 Consumption
Authors: Zhang Shitong , Han Guilin , Zeng Jie , Xiao Xuhuan , Malem Fairda
Published: November 2021

As the largest and most representative tributary of the Mekong River, the Mun River Basin (MRB) provides critical understanding of regional hydro-geochemical features and rock weathering processes on a basin scale. The present study measured strontium (Sr) isotopes with hydro-geochemistry data of 56 water samples in detail in the MRB in northeast Thailand. The dissolved Sr contents and 87Sr/86Sr isotopic ratios were reported to be 8.7–344.6 μg/L (average 126.9 μg/L) and 0.7085–0.7281 (average 0.7156), respectively. The concentrations of dissolved Sr in the mainstream slightly decreased from upstream to downstream, while the variation trend of 87Sr/86Sr was on the contrary. Correlation analysis showed that Na+ strongly correlated with Cl− (0.995, p < 0.01), while Ca2+ exhibited weak relationships with SO42− (0.356, p < 0.01). Samples of the MRB exhibited lower Mg2+/Na+, Ca2+/Na+, HCO3−/Na+ and 1000Sr/Na ratios, and gathered around the end-member of evaporite dissolution, with slight shift to silicate weathering end-member, demonstrating the dominant contribution of evaporite dissolution and silicate weathering on dissolved loads. Comparing with data of major world rivers from previous research, our results remained consistency with rivers draining through similar geological conditions. The dissolved Sr flux to the adjacent Mekong River was estimated to be 20.7 tons/year. In accordance with the forward model, silicate weathering rate and CO2 consumption rate during dry season were calculated to be 0.73 tons/km2/year and 1.94 × 104 mol/km2/year, and may get underestimated due to intense water consumption by extensive agricultural activities. The superimposed effect of anthropogenic impacts on the water environment could enhance chemical weathering, and thus should be taken into account in regional ion cycles and carbon budgets. These findings highlight the coupling analysis of Sr isotopes and hydro-geochemistry in Earth surface processes and provide basic investigation for sustainable regional water treatment mechanisms in the pan basin of the Mekong River.
UTILIZA��O DE ZE�LITA COMERCIAL PARA TRATAMENTO DE EFLUENTES SINT�TICO E NATURAL CONTAMINADOS, VISANDO REMO��O DE �ONS Ag+ E Mn2+.
Authors: Henauth Pedro Henrique Leite Lustosa , Silva Ana D�lia Santos da , Soares Isa�as Barbosa
Published: November 2021

Devido ao crescimento das ind�strias e da tecnologia desde a revolu��o industrial, ocorrida em meados do s�culo XVIII, houve um enorme aumento na produ��o de res�duos, sejam eles s�lidos, l�quidos ou gasosos, gerando um problema em rela��o ao descarte incorreto dos efluentes. No Brasil, grandes quantidades de efluentes l�quidos carregam em sua composi��o metais pesados que s�o produzidos e descartados diariamente sem nenhum tratamento apropriado, tornando-se um grande problema para os solos e para o meio ambiente em geral. Assim, torna-se necess�rio investir em alternativas de tratamento de efluentes l�quidos para o correto descarte desses rejeitos. O objetivo do presente trabalho foi estudar a viabilidade do uso de ze�litas, que s�o rochas de forma��o natural, no tratamento de efluentes sint�ticos, atrav�s do estudo do seu potencial de adsor��o frente a metais pesados presentes em alguns tipos de efluentes contaminados. Para isso, foi criado um efluente sint�tico rico em �ons prata (Ag+) e estudou-se sua adsor��o em um tipo de ze�lita comercial, bem como foi aplicado este mesmo tipo de material para estudar a adsor��o de �ons mangan�s (Mn2+) em um efluente natural proveniente de um manancial. Separadamente, os efluentes foram colocados em contato com a ze�lita e submetidos � uma agita��o de 120 rota��es por minuto em um agitador magn�tico, a diferentes temperaturas (temperatura ambiente de 25�C �e 70�C) durante 2 horas. Os resultados indicaram uma efici�ncia de remo��o de �ons Ag+ de 34,99% e 54,46% para as temperaturas ambiente e 70�C, respectivamente e, para os �ons Mn2+, de 40,00% e 81,31% para as mesmas respectivas temperaturas, mostrando que a ze�lita comercial estudada possui uma eficiente capacidade de adsor��o desses metais com potencial aplica��o nas esta��es de tratamento de efluentes.�
Light Scattering by Pure Water and Seawater: Recent Development
Authors: Zhang Xiaodong , Hu Lianbo
Published: November 2021

Light scattering by pure water and seawater is a fundamental optical property that plays a critical role in ocean optics and ocean color studies. We briefly review the theory of molecular scattering in liquid and electrolyte solutions and focus on the recent developments in modeling the effect of pressure, extending to extreme environments, and evaluating the effect of salinity on the depolarization ratio. We demonstrate how the modeling of seawater scattering can be applied to better understand spectral absorption and attenuation of pure water and seawater. We recommend future efforts should be directed at measuring the polarized components of scattering by pure water over a greater range of wavelengths, temperature, salinity, and pressure to constrain and validate the model and to improve our knowledge of the water’s depolarization ratio.
Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
Authors: Ebhohimen Israel Ehizuelen , Okolie Ngozi Paulinus
Published: November 2021

Background: The continued use of bromate due to its oxidizing property poses health hazards since it is an established nephrotoxic agent. Objectives: This study evaluated the capacity of the ethanol extract of Aframomum angustifolium seeds to ameliorate the nephrotoxicity of potassium bromate in Wistar rats. Methods: In stage I of this study, the main phytochemical groups in the seeds were quantified using spectrophotometric procedures. The acute and sub-chronic toxicities of the extract were studied by monitoring physical and biochemical parameters in stage II. In stage III, the reno-protective effect of the extract were determined by administering 350 and 750 mg/kg bw of the extract with 30 mg/kg bw potassium bromate orally. The reno-protective study lasted for 56 days and the effect of treatment on biomarkers was determined on days 28 and 56. Results: The phytochemical groups (i.e., alkaloids, flavonoids, saponins, tannins, ascorbic acid, and alpha-tocopherol) were detected in the seeds. The acute and sub-chronic oral administration of the extract did not induce any significant toxic reactions across the studied concentrations. The sub-chronic administration of the extract reduced average weight gain in the treated groups. The obtained results in the reno-protective and histological studies indicated that the seed extract offers protection against the induced oxidative assault by bromate. Conclusion: In general, the co-administration of the ethanol extract of A. angustifolium seeds with bromate can reduce its nephrotoxicity in a dose-dependent manner.
Unexpected Detection of Abnormal Hemoglobin Variants During Routine HbA1c Analysis by HPLC Technique: Challenges and Opportunities in HbA1c Testing
Authors: Sreedevi Neelam Narsingrao , Kumar Guduru Vijay , Chendar Boda , Vijaya Bhaskar Madrol , Sai Baba Kompella Sree Satya , Krishna Mohan Iyyapu
Published: November 2021

Background: Glycated Hemoglobin A1c (HbA1c) assay is most widely used in diabetic patients for assessing long-term control of glycemia. The presence of hemoglobin variants may be an incidental finding and can interfere with HbA1c measurements. The aim of the present study is to investigate the prevalence and impact of interference of different abnormal hemoglobin variants on HbA1c measurements during routine HbA1c testing. Methods: A total of 12,092 HbA1c samples were collected from January to August 2018. HbA1c quantification was carried out on a Variant II Bio-Rad’s HPLC analyzer. Abnormal chromatograms were further analyzed using the extended-run high-pressure liquid chromatography (HPLC) analysis in the A2/F mode. Results: The samples were examined for presence of abnormal variants. Samples producing abnormal chromatograms were further analyzed in A2/F mode to characterize hemoglobin variants. Abnormal variants were identified in 126 (1%) samples, and 74 (0.59%) sickle cell traits (SCT) were the most common variant in our findings. Moreover, 30 (0.24%) cases were eluted in the variant window in A1c mode, which on further analysis were found to be Hb E & Hb D traits. Furthermore, 3 (0.02%) cases were eluted at a RT <1 min as (unknown) and identified as Hb H. Also,19 (0.15%) samples were eluted in the P3 window at different retention times. Conclusion: Observing each chromatograph after the analysis can help us in identifying silent hemoglobin variants in routine HbA1c testing. Knowledge and awareness of common hemoglobin variants affecting measurement of HbA1c is imperative to avoid reporting of falsely low HbA1c values in diabetic population.
Neuromuscular Blocking Agent Use in Acute Respiratory Distress Syndrome: Which Variable is Important?
Authors: Rahimibashar Farshid , Salesi Mahmood , Vahedian-Azimi Amir , Khosh Fetrat Masoum
Published: November 2021

Background: The study of neuromuscular blocking agents (NMBAs) in the management of acute respiratory distress syndrome (ARDS) has provided conflicting results in terms of their effect on mortality. Objectives: The main purpose of this study was to evaluate mortality in ARDS patients who underwent NMBA. Methods: A retrospective secondary analysis of 4200 patients with ARDS was collected from two academic medical centers, Tehran, Iran. This study was performed to assess the impact of NMBAs use in ARDS patients with different subgroups including mild and moderate-to-severe ARDS, age more and less than 65 years, having medical turnover vs. not-having, and high acute nursing care vs. moderate to low nursing care. Results: Intensive care unit (ICU) mortality has occurred in 1169 (27.8%) participants. The mortality rate was 28.6% and 27.5% in patients with mild and moderate-to-severe ARDS, respectively. In the subjects without medical turnover, the moderate dose of NMBAs significantly reduces the mortality of patients (P=0.044). In patients who need high acute nursing care, increasing the NMBAs dose significantly reduces patients’ mortality (P=0.010). In addition, increasing the NMBAs doses significantly reduces ICU length of stay (LOS). Conclusion: This study provides evidence that the administration of different doses of NMBAs had no effect on patients’ mortality with mild or moderate-to-severe ARDS. However, higher doses of NMBAs than low doses increased the risk of mortality in patients over 80 years and can reduce the risk of death in patients less than 55 years.
Prevalence of Renal Colic in the Emergency Departments: A Multi-center Study
Authors: Torabi Mehdi , Shojaee Fahimeh , Mirzaee Moghaddameh
Published: November 2021

Background: Kidney calculi are the most common cause of kidney failure. Objectives: This study aimed to investigate the prevalence of renal colic and its risk factors in the patients referred to two emergency departments during a year. Methods: This was a descriptive cross-sectional study conducted in two hospitals in Kerman city, south-east of Iran, for one year from March 2019 to March 2020. All the archives of the two emergency departments were reviewed, and the required information was recorded in a checklist. The data was analyzed in SPSS 20 software. Results: A total of 504 patients were included in the study. The prevalence of renal colic was 0.5%. Most of the patients (58.5%) had an age between 19 and 39 years, and the majority (60.1%) were males and had a body mass index (BMI) above 25. A family history of renal colic was reported in 68.7% of the patients, and 63.9% had either hypertension or diabetes. Most of the patients consumed less than 3 liters of water per day. The highest referrals were seen in autumn (31.5%) and summer (27.4%). Conclusion: Considering the relationship between renal colic and age, sex, BMI, occupation, a family history of the disease, the presence of underlying diseases, the amount and type of drinking water, and the season of referral, it is recommended to control these risk factors to reduce the incidence of the disease.
Nephrotoxicity induced by vascular endothelial growth factor inhibitors
Authors: Badri Shirinsadat , Siberian Lillian , Soltani Rasool , Moghaddas Azadeh , Ataei Sara , Momenzadeh Mahnaz
Published: November 2021

Vascular endothelial growth factor (VEGF) is a special mitogen for vascular endothelial cells, an essential endogenous angiogenic cytokine, and the principal controller of vascular growth that plays a fundamental role in therapeutic angiogenesis pathways. VEGF-targeted therapy is categorized into the group of angiogenesis inhibitors that inhibit the expression or the activity of VEGF. It comprises counteracting VEGF antibodies, VEGF receptors, VEGF-trap, and tyrosine kinase inhibitor (TKIs) with selectivity for VEGF receptors. The kidney is both a target and a source of VEGF. VEGF may be a vital mediator to restore some types of renal diseases (e.g., non-diabetic renal diseases) and harmful in some other diseases (e.g., diabetes and diabetes complications). Due to their ability to prevent angiogenesis, VEGF inhibitors have been found as a powerful tool to treat angiogenesis-dependent diseases, including cancer and diabetic retinopathy. VEGF preserves the renal structure and function in normal physiologic conditions. Therefore, all treatments that inhibit the VEGF pathway may lead to renal disorders, especially renovascular diseases such as hypertension, proteinuria, nephrotic syndrome, decreased glomerular filtration rate (GFR), and thrombotic microangiopathy (TMA). In the present study, we reviewed some related reports and associated mechanisms, especially for hypertension and proteinuria.
Comparison between paricalcitol versus cinacalcet therapy in the management of secondary hyperparathyroidism among prevalent hemodialysis patients
Authors: Behairy Maha A. , Mahmoud Osama , Ibrahim Ayman Rabie , Baki Aber H.
Published: November 2021

Introduction: Secondary hyperparathyroidism (SHPT) is one of the components of chronic kidney disease–mineral bone disorder (CKD-MBD) with significant contribution to the morbidity and mortality among prevalent hemodialysis (HD) patients. Objectives: This multi-centric experience study aims to compare the effectiveness of intravenous (IV) paricalcitol versus oral cinacalcet and oral cinacalcet plus oral alfacalcidol as treatment regimens of SHPT among chronic HD patients. Patients and Methods: This is a retrospective observational cohort study, in which 130 prevalent HD patients with SHPT was recruited from three main HD centres of Aljouf region in Saudi Arabia. Patients were divided into three groups; group I (50) HD patients were treated by IV paricalcitol, group II (50) HD patients who received oral cinacalcet plus oral alfacalcidol, group III (30) HD patients were on oral cinacalcet. Serum intact parathyroid hormone (iPTH), calcium (Ca), phosphorus (Po4) and alkaline phosphatase (ALP) tests were assessed at 0, 3, 6, and 9 months. Results: A total of 130 (61 (47%) females, (53%) 69 males) HD patients with mean age 56.30 ± 19.1 years, and with mean HD duration of 4.86±4.15 years were enrolled in the study. The mean of iPTH is significantly reduced in all studied groups (P<0.001). Mean Δchanges in iPTH concentration in groups I, II, III were -242.11±148.75, -225.54±153.91 and -254.83±275.17 respectively; P>0.05) with statistical non-significant differences. Increase of Ca×Po4 with paricalcitol group as mean ΔChange in (Ca×PO4) was in the groups I, II, III (15.39±9.46, 1.97±11.74, -2.89±9.37) respectively (P<0.001). Our study showed a significant increase in serum phosphorus from the baseline in patients of group II. Conclusion: IV paricalcitol based regimen assumed to be equally effective in suppressing SHPT in HD patients when compared to the combination of oral cinacalcet with oral alfacalcidol or treatment with oral cinacalcet alone.
Oral versus intramuscular cholecalciferol replacement in hemodialysis patients with vitamin D deficiency
Authors: Behairy Maha A. , Elsharabasy Reem M. , El Shaarawy Abdel Bassit , Anwar Walid , Mahmoud Zeinab Ahmed , Khedr Lina Essam
Published: November 2021

Introduction: Low 25-hydroxyvitamin D (25(OH)D) level in hemodialysis (HD) patients is associated with high bone turnover, secondary hyperparathyroidism, and decreased bone mineral density (BMD). Objective: To investigate the efficacy of equivalent doses of pulse oral cholecalciferol versus intramuscular (IM) cholecalciferol in correcting serum 25(OH)D levels in HD patients with vitamin D deficiency. Patients and Methods: In a prospective randomized open-label clinical trial, 80 HD patients with 25(OH)D level <20 ng/mL and serum intact parathyroid hormone (iPTH) level >100 pg/mL were enrolled in the study. Patients were divided into two groups. Group I: 40 HD patients received oral cholecalciferol 25 000 IU weekly for 12 weeks. Group II: 40 HD patients received a single dose of IM cholecalciferol 300 000 IU. Patients were maintained on their regular medications as alfacalcidol or phosphate binders. Serum calcium, phosphorus, 25(OH)D, alkaline phosphatase and iPTH were monitored at 0, 6th, and 12th week of intervention. Results: Significant increase in serum 25(OH)D level in group II patients who received IM (intramuscular) cholecalciferol, with delta mean a change of vitamin D level was 2.92 ±7.29 ng/mL over three months in comparison to the insignificant change in oral cholecalciferol group. Additionally there was a significant increase in the mean of serum calcium in comparison to oral cholecalciferol group, while we found a statistically significant decrease in alkaline phosphatase level in both groups too (P<0.05). The mean of iPTH levels was reduced significantly with IM cholecalciferol dose (1064.00 ± 787.60 to 609.9 ± 551.41 pg/mL; P<0.05). Conclusion: Intramuscular cholecalciferol dose is more effective at increasing 25(OH) D levels in dialysis patients than oral supplementation, achieves more increase in serum calcium and reduce iPTH levels. However, the longer duration of treatment is required to achieve recommended levels of vitamin D and suppress high iPTH levels.
Prevalence of nephropathy and proximal tubule disorder in human immunodeficiency virus patients under tenofovir therapy
Authors: Sabzghabaei Foroogh , Sedighi Afsaneh , Shahi Raziyeh , Mahmoodi Vahid , Khamseh Jahanbakhsh , Rahimian Neda
Published: November 2021

Introduction: Tenofovir is a common therapy in human immunodeficiency virus (HIV) patients. Objective: This study was carried out to determine the prevalence of nephropathy and proximal tubule disorder in HIV patients under tenofovir therapy. Patients and Methods: In this study, 160 HIV patients under tenofovir therapy were enrolled and the prevalence of nephropathy and proximal tubule disorder was determined and compared. Results: We found, the proximal tubule involvement in 25%, 6.8%, 2.2% and 0% in first year, 2–5 years , 6–10 years and 11–18 years of disease involvement respectively, (P = 0.02). The mean glomerular filtration rate (GFR) diminution was 2.15%, 10.53%, 12.6% and 17.79%, in the first, 2–5, 6–10, and 11–18 years, respectively, again showing a significant difference between years (P = 0.02). Proteinuria was seen in 13.1% of patients. Conclusion: We concluded that GFR diminution and proximal tubule involvement are common and important to be managed in HIV-positive patients under tenofovir therapy, and discontinuation of drug has no positive effect on GFR.
A comparative study on the effect of calcitriol and cinacalcet on hyperparathyroidism in hemodialysis patients; a double-blinded randomized clinical trial
Authors: Mardani Saeed , Filsouf Faranak Sadat
Published: November 2021

Introduction:Chronic kidney disease (CKD) has lots of complication like calcium and phosphate metabolism disorders, hyperparathyroidism, vitamin D deficiency and metabolic acidosis. Objectives: The aim of this study was to determine and compare the effect of calcitriol and cinacalcet on hyperparathyroidism in hemodialysis patients due to end-stage renal disease (ESRD). Patients and Methods: This study was a double-blinded randomized clinical trial, which was conducted on 60 hemodialysis patients in 2017-2018. The patients were randomly assigned to two groups of 30 patients, which one group was treated with cinacalcet and the other group was treated with calcitriol. During this study, phosphorus, calcium and iPTH were measured. Results: The results showed that in the group treated with cinacalcet, the amount of calcium [t(22)=0.294, P>0.05] and the amount of phosphorus [t(22)=1.87, P>0.05] did not change significantly while iPTH values before and after the study had statistically significant difference [t(22)=4.37, P<0.05]. In group treated with calcitriol, the calcium, phosphorus and iPTH values did not change significantly (P>0.05). Calcium changes in the cinacalcet group compared to the calcitriol group [t (47) =-1.14, P>0.05] and also, the amount of phosphorus changes [t (47) =-1.022, P>0.05] was not statistically significant. The iPTH changes were not statistically significant between the two groups however iPTH in the calcitriol group was higher than the cinacalcet group [t (47) =-1.13, P>0.05]. Conclusion: In contrast to calcitriol, cinacalcet significantly reduced iPTH and did not significantly change calcium and phosphorus levels. Trial Registration: The trial was registered by Iranian Registry of Clinical Trials (IRCT) (identifier: IRCT20190702044076N1; https://en.irct.ir/trial/40547, Ethical code# IR.SKUMS.REC.1397.026).
Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
Authors: Shahsavarinia Kavous , Ghojazadeh Morteza , Sanaie Sarvin , Vahedi Leila , Ahmadpour Mahta , Mahmoodpoor Ata , Soleimanpour Hassan
Published: November 2021

Background Many of the known coronaviruses cause a wide range of respiratory infections in humans, and the novel coronavirus is no exception to this rule. Although no drug has yet been discovered to prevent or treat this disease, chloroquine (CQ) and hydroxychloroquine (HCQ) have been widely used in studies showing different results. Methods The present study is an umbrella study. The search was conducted for the articles published from January 2020 to November 2020 using the keywords ("COVID-19" OR "SARS-CoV-2" AND "Hydroxychloroquine" OR "Chloroquine" AND "Systematic Review" OR "Metanalysis"). This study was limited to human samples and systematic reviews with or without meta-analysis. The quality of the articles was also evaluated independently by two researchers. Results To evaluate the clinical efficacy of HCQ and CQ, a total of 176 papers and 643569 cases ranging from patients with mild pneumonia to intubated critically ill patients were evaluated. Finally, 8 studies were included. Conclusion There are conflicting results regarding HCQ or CQ efficacy and safety in the systematic reviews. More evidence is needed to confirm whether these drugs are useful in COVID-19 infection, and their usage as the standard care cannot be recommended based on the majority of the studies included in this umbrella review.
Analisis Kesesuaian Ekowisata Mangrove Di Desa Taddan Kecamatan Camplong Kabupaten Sampang
Authors: Pratiwi Maywa Widiya , Muhsoni Firman Farid
Published: November 2021

Kawasan hutan mangrove memiliki keanekaragaman hayati dan biota yang beragam, kawasan ini potensial dikembangkan sebagai kawasan ekowisata bahari. Tujuan penelitian ini untuk mengetahui indeks kesesuaian wisata, daya dukung kawasan, dan daya dukung pemanfaatan ekowisata mangrove di Desa Taddan Kecamatan Camplong Kabupaten Sampang. Metode pengambilan data mangrove menggunakan transek garis dan plot (Line Transect Plot). Hasil penelitian mendapatkan jenis mangrove di lokasi penelitian adalah Rhizophora stylosa, Rhizophora mucronata, Rhizophora apiculata, Sonneratia alba, Avicennia marina, dan Aegiceras cornitulatum. Kesesuaian kawasan untuk dimanfaatkan sebagai kawasan ekowisata bahari kategori mangrove untuk semua stasiun pada kondisi sesuai bersyarat. Daya dukung kawasan menunjukkan hasil kemampuan suatu kawasan dalam menyediakan ruang bagi pemanfaatan sebanyak 199 orang per hari, sedangkan untuk per trip sebanyak 25 orang per trip. Daya dukung pemanfaatan dengan mempertimbangkan persentase kawasan untuk konservasi sebesar 10% maka diperoleh hasil sebanyak 20 orang per hari
ANALISIS PUTUSAN PENGADILAN NEGERI SURABAYA NOMOR: 3094/PID.B/2013 TENTANG ALAT BUKTI OLEH HAKIM DALAM PASAL 114 AYAT (2) JUNCTO PASAL 132 AYAT (1) UU RI NOMOR 35 TAHUN 2009 TENTANG NARKOTIKA
Authors: Aran Tobias Gula
Published: November 2021

Abstract In this research examines two issues, namely the Surabaya District Court Decision No. 3094 / Pid.B / 2013 In accordance with Evidence presented at trial and Parameter Verification assessed Judges in Crime Article 114 paragraph (2) in conjunction with Article 132 ( 1) Act No. 35 of 2009 on Narcotics, based on a normative juridical research, using the approach of Legislation, Case approach, analytical approach, the purpose of this study was to analyze the state court decision Surabaya number: 3094/Pid.B/2013 appropriate evidence presented at the hearing, stated that in this ruling the judge has not given a sense of justice for law enforcement against criminal acts Narcotics correspond to the penalty set out in the Act, and to describe the parameters of proof is rated Judge in a criminal act of Article 114 paragraph (2) in conjunction with Article 132 paragraph (1) of Law No. 35 Year 2009 on Narcotics, as the basis of the assessment of evidence by the judge.Keywords: Court Decision Analysis, Evidence, Narcotics
PERTANGGUNGAN KECELAKAAN PENUMPANG ANGKUTAN BERBASIS APLIKASI ONLINE DALAM PERLINDUNGAN DASAR PEMERINTAH
Authors: Kusumo Guntur Rubyantoro
Published: November 2021

ABSTRACT             The development of technology gave birth to a new system in passenger transportation vehicle, one of that development is online-based transportation. The transportation user is increasing, but there was obscured legal relations between passengers, online-based transportation companies and insurance company. Legal certainty of security guarantee, safety and passenger protection to get insurance according to Law Number 33 Year 1964 also vague from social-security context.             This study used normative juridical method. Statute Approach and Conceptual Approach with normative analysis (Content Analysis) used to examine the legal substance that has collected using literature study on the main legal substance sources of Law Number 33 Year 1964 and Law Number 22 Year 2009 .            The results of this research convice that legal relations created between passengers and online-based transportation companies is the conveyance agreement, while the online-based transportation companies with the insurance company is the compulsive insurance, as the premium payer is the online-based transportation companies and the insured is the passenger with State-Owned Enterprise insurance company as the insurer. Guarantee from Law Number 33 Year 1964 given to casualty if the victims get injury or disability, but if they gone, the insurer gave compensation to their heir. The premium amount and passenger insurance was stipulated in Regulation of the Finance Ministry Number 15/PMK/0.10/2017. Insurance scope guarantee from board until debark the online-based transportation. Suicide, vehicle races, accident due to war, and natural disaster makes claim rejected. Insurance expiration is six months from accident, three months since submission, and three months after approval for insurance payments.  Keywords: Coverage, Basic Protection, Onlinse-based Application
PENYELESAIAN SENGKETA BATAS ANTAR DAERAH
Authors: Patongloan Andre Junianto
Published: November 2021

Abstract Inter-regional Border Dispute Resolution by Andre Junianto Patongloan and guided by Dr. Marthen B. Salinding, Salinding, SH, MH and Dr. Basri, SH, M.Kn. In a study of this, the formulation of the problem that is raised among others: 1. Urgency Affirmation of Region in the Formation of Territory, 2. Efforts Law Against Settlement Dispute Regional Boundaries. The study is intended to examine is normative and examine the issue of the legal use of the principles of law as well as by using a methodology approach to regulation law - law (statue approach) and the approach of the case (case approach). That regional autonomy is a promising manifestation for the region, which is tight relation to the boundaries of the area that was in the area of autonomous mentioned. Problems boundary area has a dimension that is very complex, such as; conflict social, conflict sources of the power of nature, conflict ethnicity /culture /ethnicity and so forth. Completion tiered by the Governor and the Minister in the State, is a form of public law in the name of the state. The role of the Governor and the Minister in the State shows the behavior of an active state, as affirmed in the principle of the modern state. Form of settlement of disputes boundary region between regions as part of the implementation of the functions of government found their Autonom organs of government ( vrijbevoegdheid), discretionary or Freiesermessen ), this is because the regulatory legislation that no-load norms are vague ( voge norm), the norm is open (open norm ) or contains a choice (choice) . In this case, it must be understood that what is done by a government organ is not in a capacity as a function of hearing or as a function of legislation. Settlement of disputes boundary region between regions that pursued by the mechanism of the law of the country through the agency of justice which there has been expected to provide legal certainty and a sense of justice. In preventing the confusion of the conflict norm on several levels of regulation law for the settlement of disputes boundary region between regions. the principle of cooperation between regions can be relied upon to translate legal certainty and provide a sense fair for the government area to organize and manage the limits of its territory as one of the supporting creation of the implementation of the autonomous regions that good.Keyword: Establishment of Regional, Local Limits, Settlement Dispute.
REDESAIN RANCANGAN UNDANG UNDANG OMNIBUS LAW CIPTA LAPANGAN KERJA
Authors: Kurniawan Basuki
Published: November 2021

ABSTRACTIklim investasi sulit berkembang bilamana terlalu banyaknya aturan yang tumpang tindih dari pusat hingga daerah, serta dengan prosedur perizinan yang lama menjadi suatu sumber masalah yang tidak kunjung selesai. Melihat hal tersebut Presiden Jokowi membuat trobosan dengan menggunakan Omnibus Law Cipta Lapangan Kerja atau sering kali disebut dengan RUU Omnibus Law Cilaka. Hal ini merupakan sesuatu yang baru di Indonesia, namun itu merupakan suatu terobosan dalam menyelesaikan kesemerawutan hukum di Indonesia. Namun keinginan dari Pemerintah mendapatkan respon gelombang demo yang cukup besar dari golongan buruh dan masyarakat. Demo itu didasarkan isi dari pasal-pasal dalam RUU Omnibus Law Cipta Lapangan Kerja yang dianggap merugikan masyakat Indonesia dan golongan buruh. Berdasarkan pendapat yang penulis sampaikan, kami menyimpulkn beberapa hal. Pertama, RUU Omnibus Law Cipta Lapangan Kerja memiliki beberapa koreksi yang lebih dalam khususnya dalam aspek paradigma serta substansi pengaturan mengenai PHK, Izin, serta Otonomi Daerah (Desentralisasi). Kedua, niatan adanya RUU Omnibus Law Cilaka yakni untuk mengurangi adanya hyper regulation (banyaknya peraturan perundang-undangan), namun dalam RUU malah menciptakan aturan turunan yang membuat semakin banyaknya aturan baru yang dimunculkan. Maka seyogyanya RUU Omnibus Law Cipta Lapangan Kerja ini perlu di atur ulang dengan tetap mengikut sertakan masyarakat luas dalam memberikan masukan dan pandangan demi sempurnanya RUU Cipta Lapangan Kerja ini. Kata Kunci: Omnibus Law, Cipta Lapangan Kerja.
ВІРУСНА КОМУНІКАЦІЯ ТА РЕКЛАМА: ОСОБЛИВОСТІ ВПЛИВУ
Authors: Родінова Наталія
Published: November 2021

У статті розглянуто роль вірусної комунікації як вдалий інструмент впливу на аудиторію. Вказано, що вірусний контент приваблює аудиторію завдяки використанню актуальності та креативності сюжету, більшій увазі гумористичній складовій, змістові та інтерактивності, можливості користувачів брати участь у розвитку подальших подій, ставати співтворцями контенту. Представлений матеріал дозволив зробити наступні висновки: активна включеність у соціальні мережі сприяла збільшенню кількості вірусних повідомлень, які завдяки концентрованим емоційним складовим здатні керувати аудиторією. У свою чергу окрема особа, поширюючи контент через соціальні мережі, перетворюється у складову частину групи, створюється можливість реалізації функції соціальної участі.
ЗАПОБІГАННЯ ТА ПРОТИДІЯ ДОМАШНЬОМУ НАСИЛЬСТВУ (НА ПРИКЛАДІ м. ЛЬВОВА)
Authors: Комаринська Зоряна
Published: November 2021

Стаття присвячена аналізу проблеми домашнього насильства, пошуку шляхів її подолання, подано характеристику видів та методів профілактики. Проаналізовано причини та динаміку зростання чисельності випадків домашнього насильства в Україні та у м. Львові, зокрема. Докладно описано діяльність державних та комунальних установ, громадських і благодійних організацій, що працюють із жертвами насильства. Встановлено, що на сьогодні є позитивні досягнення у сфери запобігання та профілактики домашнього насильства. У статті наголошено, що робота, проведена у Львові у цьому напрямку, заслуговує на увагу та поширення як позитивний досвід в інших регіонах України.
РЕАКЦИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ СТУДЕНТОК НА ПСИХОЭМОЦИОНАЛЬНУЮ НАГРУЗКУ
Authors: Сидоряк Наталья , Шкуринская Дарина , Головко Андрей , Вьюницкий Владимир
Published: November 2021

проведены исследования изучения изменений сердечно-сосудистой системы и микроциркуляции крови у студенток в процессе психоэмоциональной нагрузки. Показано, что психоэмоциональный стресс вызывает изменения сердечно-сосудистой системы, происходящие за счет включения вегетативной нервной системы, в частности, симпатической нервной системы. Выявлены изменения микроциркуляции, которые говорят о разных механизмах регуляции сосудистого тонуса после влияния психоэмоциональной нагрузки.
ВИКОРИСТАННЯ WEB-ТЕХНОЛОГІЙ ПІД ЧАС ІНШОМОВНОЇ ПІДГОТОВКИ СТУДЕНТІВ НЕФІЛОЛОГІЧНИХ СПЕЦІАЛЬНОСТЕЙ
Authors: Котелянець Юлія
Published: November 2021

Використання освітніх Web-технологій у викладанні іноземних мов підвищує ефективність навчання лексики, граматики, аудіювання, письма, говоріння. Оптимізація навчання відбувається за рахунок скорочення навчального часу, створення віртуального мовного середовища, що сприяє досягненню мети навчання. Під час вичення англійської мови застосовують Хотліст, Трежа хант, Мультимедіа скрепбук, Сабджект семпл, Веб-квест.
PULSE OXIMETERS IN ZAPORIZHZHIA PHARMACIES
Authors: Brytanova Tetiana , Samko Anatoly , Antypenko Lyudmyla
Published: November 2021

Nowadays, with the increasing number of COVID-19 cases, the focus is centered on monitoring the respiratory system, which is largely due to the ubiquitous usage of pulse oximeters for remote and self-monitoring. Thus, it was decided to study their available models presented on the websites Tabletki.ua and Liki.com of Zaporizhzhia (Ukraine).
Aplicación seriada de paricalcitol intranodular ¿Es eficaz en el tratamiento del hiperparatiroidismo secundario refractario?
Authors: Restrepo Cesar Augusto , Castillo pinilla Campo Elias , Sanz Scovino Maria Fernanda
Published: November 2021

Objetivo: Determinar la eficacia del paricalcitol en reducción de los niveles de PTH intacta (PTHi) al aplicarlo directamente en las glándulas paratiroides en pacientes con enfermedad renal crónica estadio 5 (ERC G5) en terapia dialítica con hiperparatiroidismo refractario e hiperplasia nodular. Pacientes, materiales y métodos: Pacientes con ERC G5 en terapia de diálisis e hiperparatiroidismo secundario refractario y en quienes por ecografía de cuello se detecto hiperplasia de mas de una glandula paratiroides, caracterizadas por un volumen mayor a 500 mm3. A cada paciente por guía ecográfica dirigida se le aplico 0,5 cc (2,5ugs) de paricalcitol (Zemplar®) en cada glándula hiperplasica independientemente de su tamaño, y según el grupo. En el grupo 1 (G1) recibieron paricalcitol semanal para un máximo de dos glándulas por sesión siempre del mismo lado y por un total de 2 dosis por glándula; para el grupo 2 (G2) paricalcitol cada 15 días en esquema semejante al grupo 1 para un total de 2 dosis por glándula y finalmente grupo 3 (G3) paricalcitol cada mes, pero en cada sesión se inyectaron todas las glándulas para un total de 4 dosis por glándula. Diseño: Estudio de intervención sin grupo control. Análisis Estadístico: Se evaluó si la intervención daba lugar a reducción significativa en los valores de PTHi, y las variables calcio, fosforo, calcio x fosforo y fosfatasa alcalina. Resultados: En el G1 se encontró una disminución estadísticamente significativa entre el nivel promedio de PTHi inicial y PTHi a los 30 días de iniciado el tratamiento (p=0,0077), pero no a los 51 ni 81 días. En el G2 al comparar la PTHi, con el valor detectado a los 51, 75, 105 y 135 días post-aplicación de la ultima dosis de paricalcitol, no hubo cambios significativos. En el G3 con relación a la PTHi inicial hubo reducción significativa en sus valores a los 60 días (p=0,012), 120 días (p=0,0099) y 180 días (p=0,00095), pero no a los 240 días (p=0,214049) En las demás variables (calcio, fosforo, calcio x fosforo, fosfatasa alcalina) no se detectaron cambios significativos en ningún grupo. No se presentaron complicaciones importantes. Conclusiones: En pacientes con ERC G5, en terapia de diálisis e hiperparatiroidismo secundario refractario, la administración de Paricalcitol intranodular logra reducir significativamente los niveles de PTHi, siempre y cuando se administre en grupos de dos glándulas con un intervalo de tiempo no superior a una semana, ó por administración mensual simultanea de todas las glándulas a un intervalo de cada mes
PREVALENCE OF METABOLIC SYNDROME IN COPD CASES IN CENTRAL INDIA AND ITS CORRELATION WITH BMI
Authors: Tejwani Aditya , Dave Lokendra , Agrawal Anubhav , Dube Simmi
Published: November 2021

BACKGROUND: COPD is the third leading cause of death worldwide with more than 90% of COPD
deaths occuring in low and middle income countries. While metabolic syndrome is a cluster of the most
dangerous cardiovascular risk factors , dened to be associated with prothrombotic and proinammatory states. About 20%-
25% adult population of the world have Metabolic syndrome and are three times more likely to have coronary artery disease or
stroke .
Increasing evidence shows association between Metabolic Syndrome in COPD. However, the frequency of Metabolic
Syndrome and its individual components are not still been clearly shown especially in Indian population in central India .
METHODS: This was a cross sectional study conducted at Department of Respiratory Medicine, Gandhi Medical College &
Hamidia hospital, Bhopal. 100 spirometrically conrmed COPD cases were enrolled after permission from institutional ethics
committee . Detailed history , clinical examination , laboratory parameters and anthropometric parameters were taken.
RESULTS: Mean age of patients with COPD was 60.34±10.39 years .Mean weight, height and BMI of patients was 55.86±9.43
2. 2
kg, 160.47±7.58 m and 21.65±3.01kg/m .Majority - 57% patients had normal BMI (18.5 to 22.9 kg/m ). About 25% and 11%
patients were overweight and underweight respectively.
Metabolic syndrome was found to be present in 32% of the patients with COPD. BMI of patients with metabolic syndrome was
signicantly higher as compared to COPD patients without metabolic syndrome (p<0.01).
CONCLUSION: The prevalence of metabolic syndrome in COPD was 32% and BMI in COPD patients with metabolic syndrome
was signicantly higher than those without metabolic syndrome .
ETIOLOGY OF NEOVASCULAR GLAUCOMA
Authors: Rao D. Kesava , Susmitha J. Naga , Rahmatunissa Rahmatunissa , Shekar Rao K Ravi , Fatima Samra Wahaj , Ather Mohammed
Published: November 2021

Purpose : To study the etiology of Neovascular Glaucoma in a tertiary eye care hospital.
Materials and methods: This is a Prospective Observational study conducted on 50 patients of
Neovascular Glaucoma presenting at a tertiary eye care hospital during a period of one year. All patients who were proved to
have NVG were included in study. Patients having corneal opacities and severe edema and those who did'nt give consent were
excluded from the study. Informed consent obtained from all the patients included in study. Detail history about systemic
disorders and ocular pathologies was taken. All patients were examined by an experienced Ophthalmologist using slit lamp,
Snellen's chart, Gonioscope, Applanation Tonometer, Indirect Ophthalmoscope, 90D slit lamp Funduscopy . FFA and Posterior
segment OCT was done in selected cases.
ResultS: Of 50 cases 16(33%) were females and 34(67%) were males. 2 (4%) patients both eyes were involved. LE was involved
in 24(48%) and RE in 24(48%) patients. Mean age of Presentation was 54.11 years with SD of (14.023). Minimum age of
presentation was 4 years and maximum was 85 years. Among 50 patients 8(16%) had Diabetes mellitus, 13(26%) had
Hypertension, 9(18%) had both DM and HTN. 20 patients had ocular disease as cause of NVG. 5(10%) had Uveitis, 11 (22%) had
PACG, 3(6%) had trauma, 3(6%) had Retinal detachment, 1(2%) had Retinoblastoma. BCVA at the time of presentation was
between 6/18- No PL.
Discussion: The most common cause of NVG in Present study is Retinal venous occlusion 16(32%) followed by PACG 12(24%),
PDR 10(20%), Uveitis 5(10%), RD 3(6%) Trauma3 (6%). Whereas in studies done in USA, China, South Korea PDR is leading
cause of NVG followed by Retinal venous Occlusion. No data was available regarding PACG.
Conclusion: In Indian population Retinal venous occlusion is the most common cause for NVG followed by PACG, Proliferative
Diabetic retinopathy is third common cause. Uveitis, Retinal detachment surgery, Trauma and Retinoblastoma are ocular
pathologies responsible for NVG.
A STUDY TO EVALUATE THE EFFECTIVENESS OF SIMULATION TRAINING ON KNOWLEDGE & PRACTICE OF CARDIO PULMONARY RESUSCITATION (CPR) AMONG FIRE& SAFETY STUDENTS IN A SELECTED INSTITUTION AT MANGALORE
Authors: V. B Sruthi
Published: November 2021

Heart disease is the world's largest killer disease claiming 17.5 million lives every year. An Indian dies of
heart problem in every 29 seconds. As many as 20,000 new heart patients develop every day in India, six
cores Indians suffer from heart disease and 30% more are at high risk by 2020. This study undertaken to evaluate the
effectiveness of simulation training on knowledge & practice of cardio pulmonary resuscitation (CPR) among re and safety
students in a selected institution at Mangalore. The Objectives of the study were To assess the knowledge and practice of re &
Safety students regarding CPR., Evaluate the effectiveness of simulation training on cardiopulmonary resuscitation among re
and safety students. Compare the post test knowledge with practice on CPR and To nd the association between pre-test
knowledge and practice score on CPR with selected demographic variables .A quantitative approach one group pre-test post
–test was adopted to evaluate the effectiveness of simulation teaching module Knowledge of participants on CPR was assessed
by using structured knowledge questionnaire and observational checklist was administered to assess the practical knowledge
level. The study concluded that the simulation training on CPR was very effective to improve knowledge and practice of cardio
pulmonary resuscitation (CPR) among re and safety students.
Assessment of the Awareness of Nigerian Professionals in the Built Environment on the Big Data analytics (BDA) Applications in the Construction Industry.
Authors: Jesse Amadosi Emmanuel
Published: November 2021

With rapid development in technology, the built industry’s capacity to generate large-scale data is not in doubt. This trend of data upsurge labelled “Big Data” is currently being used to seek intelligent solutions in many industries including construction. As a result of this, the appeal to embrace Big Data Analytics has also gained wide advocacy globally. However, the general knowledge of Nigeria’s built environment professionals on Big Data Analytics is still limited and this gap continues to account for the slow pace of adoption of digital technologies like Big Data Analytics and the value it projects. This study set out to assess the level of awareness and knowledge of professionals within the Nigerian built environment with a view to promoting the adoption of Big Data Analytics for improved productivity. To achieve this aim, a structured questionnaire survey was carried out among a total of 283 professionals drawn from 9 disciplines within the built environment in the Federal Capital Territory, Abuja. The findings revealed that: a) a low knowledge level of Big Data exists among professionals, b) knowledge among professional and the level of Big Data Analytics application have strong relationship c) professional are interested in knowing more about the Big Data concept and how Big Data Analytics can be leveraged upon. The study, therefore recommends an urgent paradigm shift towards digitisation to fully embrace and adopt Big Data Analytics and enjoin stakeholders to promote collaborative schemes among practice-based professionals and the academia in seeking intelligent and smart solutions to construction-related problems.
Pelatihan Bahasa Inggris Untuk Siswa-Siswi di TK Melati Indah Sayang-Sayang Cakranegara Mataram
Authors: Kamarudin Kamarudin , Tawali Tawali
Published: November 2021

Community service is the implementation of knowledge gained in schools, or lecturing process formally or informally. This community service aimed at giving English language training towards students of TK Melati Indah Sayang-Sayang, Cakranegara Mataram. This community service used lecturing, practice, and discussion. The respondents consisted of 30 students. The result of the training concluded that English language training towards students of TK Melati Indah Sayang-Sayang, Cakranegara Mataram was successful. It is proved from the students’ enthusiasm within the process of the training and their learning achievement after giving the training. Thus, the training of English language to the students is highly important especially in TK Melati Indah Sayang-Sayang as they will be the agent of change and future generation who will acquire English language well. Through this training, students of TK Melati Indah Sayang-Sayang are expected to have knowledge and basic experience to communicate through English language as their foundation and motivation to develop their skill.
Sistem Informasi Inventaris Berbasis Android Berbasis Android Pada SMP IT NURUL MUHAJIRIN
Authors: Permatasari Ririt DwiPutri , Sikumbang Alexsandri , Almurdani
Published: November 2021

Bidang sarana prasarana merupakan bidang yang mengelola setiap data inventaris barang pada SMPS IT NURUL MUHAJIRIN. Data-data yang telah dikelola pun akan disimpan pada catatan buku besar, data-data yang tersimpan di catatan buku bsar nantinya akan dicatatan ulang bila terjadi kerusakan pada catatan buku besar tersebut. Setelah mengetahui dasar pada penyimpanan data di catatan buku besar tidak lah memberikan jangka waktu yang lama pada data-data inventaris barang. Maka dari ini penulis melatarbelakangi untuk membuat sistem yang akan bisa digunakan pada bidang sarana prasarana untuk mendata segala inventaris barang di SMP IT NURUL MUHAJIRIN. Sistem tersebut berupa aplikasi berrbasis android dengan menggunakan metode waterfall untuk merancang dan membangun sistem aplikasi inventaris barang. Tahapan-tahapan pada metode waterfall yang akan memeberikan papapan dalam merancang dan membangun sistem inventaris berbasis aplikasi android. Sistem inventaris berbasis aplikasi android akan melakukan percoabaan pada bidang sarana prasrana di SMP IT NURUL MUHAJIRIN. Setelah selsai pada percoabaan yang dilakukan, nanti nya akan bisa dipergunakan pada bidang sarana prasarana untuk melakukan pekerjaan mendata semua mengenai inventaris barang di SMP IT NURUL MUHAJIRIN.