bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender Differences in Using Expressions of Agreement in Jordanian Spoken Arabic
Authors: Alharahsheh Entessar M. , Alharahsheh Rashed A.
Published: January 2025

This research explores the different ways Jordanian male and female university students use expressions of agreement in correlation with the contextual situation in which a different addressee is involved. The sample of students consisted of 233 males and 380 females from different Jordanian universities. To collect the required data, a questionnaire was developed and given to the respondents. The questionnaire contained three different situations, each asking the respondents about the agreement expression that they would use with three different addressees. Jordanians males and females mostly use /t’ayeb/ طيب, /ma:ʃi/  ماشي, /tama:m/  تمام, and /əʊ ˈkeɪ/ اوك to show agreement when they are asked to do something by somebody. The study shows that these expressions are synonymous but vary according to the gender of both the speaker and the addressee. Females tend to use the variant /tama:m/  تمامin most formal contextual situations, i.e., with a university professor, whereas males are more apathetic regarding the formality of this situation, using the more casual variant /əʊ ˈkeɪ/ اوك. Furthermore, both males and females tend to be polite with their parents and avoid using borrowed foreign expressions, using the most polite variant, /t’ayeb/ طيب. In another contextual situation, i.e., a close friend, males tend mostly to use /ma:ʃi/ ماشيwithin their closed networks, showing that they are more strict in using the vernacular in such situations, whereas even with their close friends, females tend to use the borrowed variant  /əʊ ˈkeɪ/ اوك to seem more casual and cool.
An Innovative Method of Teaching English for Hospitality: A Case in Bali Tourism College, Indonesia
Authors: Lestari Denok , Ekasani Kadek Ayu , Supartini Ni Luh , Sulasmini Ni Made Ayu
Published: January 2025

Teaching English for Specific Purposes (ESP) is different from teaching General English. This research aimed to demonstrate the existence of innovation in English learning strategy, called the ASRI method, as a proposed method for teaching ESP at tourism colleges. This method is a combination of Aim-Sequence-Role-Interaction (ASRI) components that can be used to promote the students’ awareness of using the appropriate language functions and improve their fluency in business-like communication. This R&D research applied the Exploratory Mixed Method which followed Logan’s model design, focusing on three stages, including problem determination, design, and development. This research was carried out at a tourism college in Bali. The subjects who were involved in the preliminary test of the ASRI method were 60 college students. Determination of the research subject used purposive sampling. The data collection tools utilized in the preliminary ﬁeld test were scoring rubrics. The analysis techniques applied to analyze the data were both descriptive quantitative and qualitative. The research results show that students’ learning outcomes have increased significantly by 81% due to the implementation of the ASRI method in studying ESP. Therefore, this model is worthy of being proposed as an innovative method for teaching ESP in tourism universities.
The Implementation of TPACK-Based Metacognitive Listening Strategies in Improving Students' Critical Listening Skills
Authors: Arono  , Nadrah  , Susanti Elvi , Harti Laspida , Wulandari Catur , Yanti Nafri , Harbelubun Y. Claudia Dhian A.
Published: January 2025

Not all students can effectively absorb and process the information they receive, highlighting the need for metacognitive listening strategies and appropriate technology to enhance their critical listening skills. Hence, this study aimed to investigate the implementation of TPACK-based metacognitive listening strategies in improving students' critical listening skills. This quantitative descriptive study utilized observation, questionnaires, and tests for data collection. The study sample comprised 88 first-semester students from the Indonesian Language Education Study Program at the University of Bengkulu. Regression test results demonstrated a positive correlation between the implementation of TPACK-based metacognitive listening strategies and students' critical listening skills, indicated by an x coefficient of 0.86 and an R2 value of 0.228 (22.80%). While TPACK implementation was primarily at the levels of knowledge and concepts, listening tests were focused on recognizing and accepting. Conversely, critical listening practice was carried out at the adapting, exploring, and advancing levels, making technology usage easier for students (96.2%). Therefore, the higher the use of TPACK-based metacognitive listening strategies by students, the more their critical listening skills improve.
Large Language Models Powered Aspect-Based Sentiment Analysis for Enhanced Customer Insights
Authors:   NOVA Information Management School (NOVA IMS), Portugal, Água Mariana , António Nuno ,   NOVA Information Management School (NOVA IMS), Universidade Nova de Lisboa & Centre for Tourism Research, Development and Innovation (CiTUR), Portugal, Carrasco Paulo ,   School of Management, Hospitality and Tourism (ESGHT), Universidade do Algarve & Centre for Tourism Research, Development and Innovation (CiTUR), Portugal, Rassal Carimo ,   School of Management, Hospitality and Tourism (ESGHT), Universidade do Algarve, & CIDEHUS - Interdisciplinary Center for History, Cultures, and Societies of the University of Évora, Portugal
Published: January 2025

In the age of social networks, user-generated content has become vital for organizations in tourism and hospitality. Traditional sentiment analysis methods often struggle to process large volumes of data and capture implicit sentiments. This study examines the potential of Aspect-Based Sentiment Analysis (ABSA) using Large Language Models (LLMs) to enhance sentiment analysis. By employing GPT-4o via ChatGPT, we benchmark three approaches: a fuzzy logic-based method, manual human analysis, and a new ChatGPT-based analysis. We analyze a dataset of 500 all-inclusive hotel reviews, comparing these methods to assess ChatGPT's effectiveness in identifying nuanced language and handling subjectivity. The findings reveal a high similarity between ChatGPT and human analysis, showcasing ChatGPT’s ability to interpret complex sentiments and automate sentiment classification tasks. This study highlights the potential of LLMs in transforming customer feedback analysis, providing deeper insights, and improving responsiveness in the hospitality industry. These results contribute to academia by presenting a framework for using LLMs in ABSA and guiding future applications and development.
Assessment of the knowledge and uptake of voluntary HIV testing and counselling services among mothers in Yenagoa, Bayelsa State
Authors: Ngwu Faith A. , Bassey Peace U. , Sule Azeezat O. , Salawudeen Oyekola A. , Iloh Evangeline C. , Bakare Omonike C. , Musa Asmaa , Alex Merin , Shehata Zeinab , Ali Samar T. , Alawadat Bassim O. , Isiaka Amarachukwu B. , Ihenacho Peniel O.
Published: January 2025

Background: Voluntary counselling and testing (VCT) for HIV has proven to be an effective way to tackle the problem of HIV/AIDS. Many however do not utilize these services for various reasons which acts as an impediment in the delivery of the services. This study aimed to assess the knowledge, attitude and utilization of VCT-HIV services among pregnant women and mothers in Bayelsa State.
Methods: This was a hospital-based, descriptive analytic study among 301 adult mothers attending the antenatal and immunization clinics of the federal medical centre, Yenagoa, Bayelsa State. An interviewer-administered questionnaire having 6 sections was used to elicit data of the mothers’ knowledge, attitude and utilization of VCT-HIV services at the health facility as well as barriers affecting the utilization of the services. Descriptive and inferential analyses were conducted and the level of significance was set at 0.05.
Results: The 59.1% of respondents had heard about VCT-HIV. Most had adequate knowledge 268 (89.0%) and good attitude 270 (89.7%) towards VCT-HIV. About 197 (65.4%) had utilized VCT-HIV services in the past, and 241 (80.1%) were presently willing to use these services. Fear of knowing their HIV status, discrimination, family stigma, among others, were factors hindering utilization of these services. Age, level of education, preferred place for delivery, knowledge and attitude towards VCT-HIV were significantly associated with the uptake of these services.
Conclusions: there is the need for government to tackle issues of discrimination against HIV-infected persons as well as sustain the delivery of maternal healthcare through the primary healthcare initiative.
Frequency of low BMD and associated risk factors in patients with inflammatory bowel disease
Authors: Saha Chinmoy , Kabir M. Anwarul , Ghosh Chanchal Kumar , Saha Ishita , Islam M. Khademul , Chowdhury M. Fazlul Karim , Das Nimai , Tanjum Tasmia
Published: January 2025

Background: Low bone mineral density (BMD) is a known complication of inflammatory bowel disease (IBD), with several factors contributing to its occurrence. This study aims to assess the frequency of BMD and identify associated risk factors in patients with IBD. The aim of this study was to determine the frequency of low BMD and identify associated risk factors in patients with inflammatory bowel disease (IBD).
Methods: This cross-sectional study included 90 patients with established inflammatory bowel disease (IBD) at the Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from June 2019 to September 2020. Patients aged 18 years and older, currently on IBD medication, were enrolled. Data on BMD, disease characteristics, and demographic factors were collected and analyzed using SPSS version 23.0.
Results: Among 90 IBD patients (mean age 31.8 years, 74.4% male, 35.6% with Crohn's), 40% were smokers. BMD results showed 34.4% normal, 40% osteopenia, and 25.6% osteoporosis. Low BMD was linked to lower BMI (20.25kg/m²) and vitamin D levels (17.45ng/ml), with regression analysis confirming vitamin D deficiency as the only independent risk factor.
Conclusions: Our study underscores the high prevalence of osteopenia and osteoporosis in Bangladeshi IBD patients, highlighting the critical need for regular monitoring and intervention focused on modifiable risk factors like BMI and vitamin D to safeguard bone health.
A cross-sectional study assessing AI-generated patient information guides on common cardiovascular conditions
Authors: Sibaa Mustafa , Douma Hugo , Mathew Ireene Elsa , Dohadwala Taha Kassim , Pradeep Harshath Odeker Kundaranahalli , Polinati Deepa , Rao Nidhi Laxminarayan
Published: January 2025

Background: Patient education is essential for management of CVD as it enables in earlier diagnosis, early treatment and prevention of complications. Artificial intelligence is and increasingly popular resource with applications in virtual patient counselling. Thus, the study aimed to compare the AI generated response for patient education guide on common cardiovascular diseases using ChatGPT and Google Gemini.
Methods: The study assessed the responses generated by ChatGPT 3.5 and Google Gemini for patient education brochure on angina, hypertension, and cardiac arrest. Number of words, sentences, average word count per sentence, average syllables per word, grade level, and ease level were assessed using Flesch-Kincaid Calculator, and similarity score was checked using Quillbot. Reliability was assessed using modified DISCERN score. The statistical analysis was done using R version 4.3.2.
Results: The statistical analysis exhibited that there were no statistically significant differences between the responses generated by the AI tools based on different variables except for the ease score (p=0.2043), which was statistically superior for ChatGPT. The correlation coefficient between both the two tools was negative for the ease score (r=-0.9986, p=0.0332), the reliability score (r=-0.8660, p=0.3333), but was statistically significant for ease score.
Conclusions: The study demonstrated no significant differences between the responses generated by the AI tools for patient education brochures. Further research must be done to assess the ability of the AI tools, and ensure accurate and latest information is being generated, to benefit overall public well-being.
Clinical profile and underlying causes of recurrent pneumonia in young children
Authors: Sen Tanusree , Datta Gokul Chandra , M. Ziaul Islam Mirza , Islam Atiqul , Jafar Iqbal Mohammed , Uddin Ahmed A. S. M. Nawshad
Published: January 2025

Background: Recurrent pneumonia is a significant health concern in children, often associated with underlying medical conditions and substantial morbidity. Identifying risk factors, clinical profiles and underlying causes are essential for timely diagnosis and management.
Methods: This cross-sectional, prospective study was conducted at Bangladesh Shishu Hospital and Institute from January to June 2022, involving 50 children aged 2 months to 5 years with recurrent pneumonia. Data were collected on clinical symptoms, underlying conditions, physical findings, immunization status, radiographic, laboratory and specialized testing findings.
Results: Cough was present in 100% of cases, followed by respiratory distress (78%) and fever (66%). Congenital heart disease was the most common underlying condition (22%), followed by developmental delay (16%) and cystic fibrosis (10%). Respiratory distress was observed in 78% of patients, with crackles (66%) and wheezing (32%) as common auscultatory findings. Bronchopneumonia was the predominant chest x-ray finding (72%), while CT scans revealed consolidation in 48.6% of cases. Sweat chloride testing confirmed cystic fibrosis in 10% of cases and echocardiography identified congenital heart disease in 31.3%.
Conclusions: Recurrent pneumonia in children is frequently associated with congenital heart disease, developmental delay and cystic fibrosis. Radiographic findings, laboratory investigations and specialized testing are crucial for accurate diagnosis and management. Timely identification of risk factors and adherence to immunization schedules are essential to reduce disease burden.
Depression but not anxiety is associated with iron deficiency anemia for patients with stage 2-4 CKD
Authors: Helvaci Ozant , Genc Ilgin , Aksu M. Hakan , Yildirim Saliha , Yasar Emre
Published: January 2025

Background: Chronic kidney disease (CKD) is a global health challenge, often complicated by iron deficiency anemia (IDA), depression, and anxiety. While the impact of IDA on depression has been well-documented, its association with anxiety in non-dialysis-dependent CKD patients remains unclear. This study aimed to investigate the relationship between IDA and neuropsychiatric disorders, specifically depression and anxiety, in patients with non-dialysis-dependent CKD stages 2-4.
Methods: A cross-sectional study was conducted in the outpatient nephrology clinic at Gazi University Hospital, enrolling 200 patients with stable CKD (stages 2-4). Depression and anxiety were measured using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. Statistical analysis included comparisons of BDI and BAI scores between anemic and non-anemic groups, along with subgroup analysis of iron-treated anemic patients.
Results: Anemia was present in 38% of patients, and anemic patients had significantly higher BDI scores (mean 13.4 vs. 9.0, p<0.001) than non-anemic patients, indicating a greater prevalence of depressive symptoms. No significant differences were found in BAI scores between the groups. However, anemic patients receiving iron supplementation had lower BDI and BAI scores compared to untreated anemic patients (p<0.001).
Conclusions: IDA was associated with a higher prevalence of depression but not anxiety in non-dialysis CKD patients. Iron supplementation may help mitigate depressive symptoms in this population. Further prospective studies are needed to explore the full potential of iron therapy in managing mental health outcomes in CKD patients.
Chemotherapy-induced adverse drug reaction of antineoplastic drugs among oncology patients in a tertiary care teaching hospital
Authors: Harshakumar Sabarinath , Kurian Sherin V. , James Josmi , George Fiyona K. , Jose Sonatta Monica
Published: January 2025

Background: The main objectives of the study were to assess the pattern of adverse drug reactions (ADRs) associated with the use of antineoplastic drugs along with their causality and severity. The study also aims to analyse the different stages of cancer, cycles of chemotherapy and the quality of life of the patients.
Methods: This prospective, cross-sectional and descriptive study was conducted among 100 patients of either sex for 6 months from April 2023 to October 2023. This study included patients above the age of 18 years who were clinically diagnosed with cancer and prescribed at least one antineoplastic drug.
Results: Most of the cancer patients belonged to stage 2 and were undergoing the third cycle of chemotherapy. Most common ADRs were alopecia, anemia and anorexia. The study revealed that 79% of ADRs were possible and nearly 21% were probable in nature. After the severity assessment, it was found that all of the ADRs were mild (level 1). It was also identified that quality of life (QoL) decreases with advancing stages of cancer.
Conclusions: Cancer, along with therapeutic agents, can impair a patient's quality of life, prompting the development of effective management strategies. Assessing the severity and causation of ADRs can help determine the right supportive care agent to improve patients' general well-being.
Preparing for tomorrows health challenges: lessons from a COVID-19 epidemic from tertiary healthcare setting in Delhi
Authors: Walecha Ambika , Goel Manish
Published: January 2025

Background: The COVID-19 pandemic highlighted the fragility of healthcare systems, underscoring the urgent need for preparedness in managing medical emergencies. This study aims to evaluate the strengths and challenges within a tertiary care hospital, focusing on the lessons learned to improve future crisis management. This qualitative study investigates the strengths and limitations of Lady Hardinge medical college and associated hospitals during the COVID-19 pandemic. The findings aim to contribute to the development of a standardized preparedness plan for future epidemics and medical emergencies.
Methods: Ethical approval was obtained, and confidentiality was maintained. The research was conducted from August 2022 to December 2023 using purposive sampling. Data were collected through interviews and focus groups with hospital staff across all levels, including administrators, faculty, residents, nurses, paramedics, and support staff. Thematic analysis was used to identify key patterns and themes related to hospital preparedness and response strategies.
Results: Key themes emerged around service delivery challenges, communication issues between departments, resource management, and psychological concerns such as the need for acknowledgment. Insights from staff during the first and second waves of the pandemic revealed both weaknesses and strengths, providing valuable lessons for managing future emergencies.
Conclusions: The study emphasizes the importance of addressing the identified challenges to strengthen hospital systems for future crises. The findings offer essential guidance in developing effective preparedness plans to enhance healthcare resilience during emergencies.
Are we ready to replace physical mock exam with an online mock exam? a survey-based comparison
Authors: Sabnis Chaitanya , Patil Abhijit , Singh Abhishek , Ganpule Arvind
Published: January 2025

Background: Mock exams have become an integral part of urology training, presently conducted in a real classroom (physical mock exam- PME). We conducted a mock exam in a virtual classroom (online mock exam- OME) for 130 urology residents. A survey was conducted to compare OME and PME.
Methods: Questionnaire was developed, consisting of 16 questions, of which two question were matrix, others had options. For the matrix questions the candidates had to rate the components of the PME and OME on a scale of 1 to 5.
Results: Out of the 130, 103 (86.55%) were eligible for analysis. Regarding, ease of understanding the question and fulfilling the expectations both modalities were rated highly (95.15% versus 93.2%, p=0.552 and 89.32 versus 83.5%, p=0.221). OME fared better than PME, with regards to the questions addressing; ease of understanding the explanation (p=0.000), fluency of interaction (p=0.000), ability to concentrate (p=0.002), feeling of involvement (p=0.000), logistic convenience (p=0.001), ability to network and ability to balance commitments (p=0.000). PME was superior in interacting with peers (p=0.000), and peer motivation helping them concentrate better (p=0.001). Out of the 103 respondents 79 (66.39%) recommended an OME for future.
Conclusions: Online platform can be effectively used to conduct a mock exam. It is not only noninferior to PME but also has many advantages. This survey shows OME has a potential to replace PME.
Key factors affecting psychosocial well-being in thalassemic children from eastern India: an institutional study
Authors: Saha Rajib
Published: January 2025

Background: Thalassemia syndromes, prevalent in Eastern India, significantly impact the psychosocial health of affected children. The challenges associated with chronic treatment and disease management underscore the need for comprehensive quality of life assessments.
Methods: This cross-sectional study was conducted at Bankura Sammilani Medical College and Hospital from July 2022 to June 2023. A sample of 371 thalassemic children aged 5-12 was analyzed using the Pediatric Quality of Life Inventory 4.0 Generic Core Scale. Socio-demographic data and psychosocial health were evaluated through parent interviews and clinical records. Statistical analyses included correlation and regression models to identify factors influencing psychosocial health.
Results: The mean psychosocial health summary score was 63 (SD=9.4), indicating significant psychosocial challenges. Key factors associated with better psychosocial outcomes included lower duration of blood transfusions, female gender, positive family history of thalassemia, and higher socioeconomic status. The regression analysis revealed that these factors collectively explained 21.3% of the variability in psychosocial health scores.
Conclusion: The study emphasizes the critical influence of gender, family history, socioeconomic status, and transfusion duration on the psychosocial well-being of thalassemic children. Integrated care approaches combining medical treatment with psychological support are essential for improving quality of life. Early intervention strategies, family support programs, and tailored treatment plans that consider gender-specific needs are recommended to address the emotional and social challenges faced by these children.
A study on patients with alcohol dependence syndrome on tablet baclofen in a tertiary care hospital
Authors: N. Harshitha , Kumar K. Pawan , Edagotu Sukanya , Pandiyan Kasthuri
Published: January 2025

Background: Many clinical trials indicate that baclofen, a gamma-aminobutyric acid agonist has efficacy for alcohol dependence to reduce the cravings of alcohol and it may also have certain common or rare ADRs.  Aim was to evaluate tablet baclofen’s adverse effects and sociodemographic profile in the treatment of ADS.
Methods: This study was carried out in MVJ Medical College and Research Hospital Bangalore, India. The socio-demographic questionnaire and NADRP was administered to 100 patients who was on tablet baclofen with alcohol dependence syndrome that were diagnosed according to the ICD-10 diagnostic criteria, as well as 100 subject all of whom gave their informed consent. The data were analysed using Microsoft excel.
Results: As a result, this present data analysis revealing that alcohol addiction was more prevalent in the 36 to 50 age group, men among women. Primary school students were more addicted to alcohol, with non-professionals, rural areas, and nuclear families having higher addiction rates. Most alcohol dependence subjects have a tobacco history and comorbid mental and behavioral disorders. NADRP scales indicate no severe adverse drug reactions in alcohol dependence syndrome patients.
Conclusions: Results showed that ADS is more prevalent in the adults, married patients lack of education, occupation, and family size also contributed to addiction. Rural areas had higher alcohol addictions than urban ones, and nuclear families were more likely to abuse drugs. The study concluded that tab. baclofen is a rational medicine for treating ADS.
Ophthalmic implications following orbital trauma
Authors: Turadagi Kishorkumar , Bellary Radhika , Channashetti Gajanan
Published: January 2025

Background: To study the epidemiology, clinico-radiological pattern of ocular injuries following orbital trauma.
Methods: A cross-sectional study was conducted for a period of 6 months, all the patients attending casualty with the history of orbital injuries were included in the study. Proper history and ophthalmological examination were done. The data were recorded in the form of various parameters like type of injury, time, place and severity of injury, site of injury, and radiological pattern of fracture.
Results: Out of 100 patients 68 patients had injuries due to road traffic accidents. Most of the victims were males (86%). The most vulnerable age group was 21-30 year (38%). Majority of the patients had lid laceration (n=43, 43%), followed by periorbital swelling with black eye in 40 patients (40%) and iris prolapse in 1 patient. Out of 40 orbital wall fracture 11 fractures were impure and 29 were pure orbital wall fracture. Most of them were orbital floor fracture and least was roof fracture.
Conclusions: Road traffic accidents can result in severe ocular trauma. Victims are usually adult males of productive age group. Frontal impacts during the accidents poses the greatest risk of orbito-facial trauma. Factors like open globe injury and multiple orbital wall fracture usually associated with poor prognosis. Use of helmet and seatbelt may reduce the risk of frontal impact and hence vision threatening ocular trauma.
Correlation of serum homocysteine with HbA1c and kidney function in type 2 diabetic patients: insights from estimated glomerular filtration rate and renal impairment
Authors: Kumar Vineet , Gulati Yuvraj , Giri Richa , Babulal Verma Rajendra Kumar , Varma Punit , Kala Chayanika
Published: January 2025

Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder associated with complications, particularly diabetic nephropathy (DN), a major cause of end-stage renal disease (ESRD). Early detection of DN is essential to prevent progression. Serum homocysteine (Hcy), a marker linked to oxidative stress and endothelial dysfunction, has shown potential in predicting vascular and renal complications. However, its relationship with glycemic control (HbA1c) and kidney function (eGFR) remains underexplored. This study examines these correlations in T2DM patients.
Methods: This cross-sectional study included 156 T2DM patients recruited from G.S.V.M. medical college, Kanpur (January 2023-April 2024). Serum Hcy, HbA1c, and eGFR were measured using standardized techniques. Pearson and Spearman correlations, along with multiple linear regression, were used to evaluate relationships while adjusting for confounders like age, diabetes duration, and lipid profile.
Results: Serum Hcy levels demonstrated a significant positive correlation with HbA1c (r=0.47, p<0.01), indicating an association with poorer glycemic control. Additionally, a negative correlation was observed between serum Hcy and eGFR (r=-0.52, p<0.001), suggesting that elevated homocysteine levels were associated with declining kidney function. These correlations remained significant after adjustments for confounders.
Conclusions: Elevated serum homocysteine is strongly associated with higher HbA1c and lower eGFR, suggesting its potential as a biomarker for glycemic control and renal impairment in T2DM. Routine homocysteine measurement could aid early DN detection and management. Further studies are needed to validate these findings.
Comparison of urethral-sparing versus non urethral-sparing techniques of robot-assisted simple prostatectomy: a systematic review and meta-analysis of sexual, functional, and surgical outcomes
Authors: Yogahutama Noka , Danarto Raden
Published: January 2025

Simple prostatectomy (SP) with urethral preservation offers various benefits. Recent advancements in technology have made urethral-sparing robot-assisted simple prostatectomy (US-RASP) more feasible. This systematic review compares the efficacy of US-RASP to non-urethral-sparing robot-assisted simple prostatectomy (Non-US-RASP). A systematic literature search was conducted on PubMed, Scopus, ProQuest, Cochrane Library, and ScienceDirect, following PRISMA 2020 guidelines up to September 2024. Meta-analyses of sexual, functional, and surgical outcomes were performed using Review Manager version 5.4. The risk of bias was assessed with the Newcastle-Ottawa scale (NOS). Six observational studies involving 615 patients were included (332 US-RASP versus 283 non-US-RASP). US-RASP significantly improved sexual outcomes, with higher 6-month ejaculatory preservation (OR 31.77, 95% CI: 13.28 to 76.02, p<0.001) and a higher 12-month MSHQ-EjD SF score (MD 6.38, 95% CI: 5.90 to 6.85, p<0.001). Surgical outcomes favored US-RASP with shorter catheterization time (MD -2.67, 95% CI: -4.63 to -0.71, p=0.008) and reduced length of stay (MD -1.39, 95% CI: -2.51 to -0.28, p=0.01). However, US-RASP was associated with a higher 12-month PVR score (MD 14.00, 95% CI: 12.33 to 15.68, p<0.001). This meta-analysis suggests that US-RASP is an effective alternative to Non-US-RASP, demonstrating better sexual and surgical outcomes despite a higher PVR. However, these findings should be confirmed with a well-designed larger randomized trial.
Integration of high-resolution imaging and minimally invasive ablation in the resection of thyroid microcarcinomas: evaluation of surgical precision and functional outcomes
Authors: Zuluaga Mauricio Zuluaga , Jiménez Melanie Victoria Gavilanez , Cervantes Elida Elizabeth Alvarado , Gastelum Jorge Luis Rivera , Jiménez Maria Luisa Guerrero , Muriel Santiago Zuluaga , Cabello Diego Andres Valdes , Noriega David Bernardo García
Published: January 2025

Since high-resolution imaging and minimally invasive ablation techniques have emerged, their integration in medical field has marks a significant advancement in oncology including thyroid microcarcinomas (TMCs) management. TMCs are small but potentially aggressive tumors. TMCs require precise intervention to balance oncologic control and thyroid function preservation. Such as the detailed ultrasonic MRI and CT scan has improved TMC’s diagnostic ability and especially, the surgery planning. They are now making it possible to map tumors and the tumor margins in real time. Technological advances to minimally invasive ablation approaches such as radiofrequency and microwave ablation (MWA) have now shifted to offer localized cancer tissue destruction with less complications than the classical thyroidectomy. These techniques produce superior functional outcomes such as voice preservation and reduced hypoparathyroidism rates as well as high procedural success rates of more than 90%. Combining sophisticated imaging and ablation increases precision while resulting in recurrence rates as low as 2-5% in low-risk individuals. Despite these developments some challenges such as operator dependency and expensive costs that limit accessibility. Evidence supports the use of these approaches as an alternative to traditional surgery for certain patients showing importance of competent operators and technological infrastructure. This paradigm shift not only improves TMC treatment, but it also necessitates additional study to maximize long-term outcomes and increase accessibility. Ethical adherence and rigorous methodologies ensure reliable evaluations of safety efficacy, and functional outcomes. Evidence supports the integration of these techniques as an alternative to conventional surgery for select patients, emphasizing the need for skilled operators and technological infrastructure. This Transformation not only refines TMC management but also warrants continued research to optimize long-term outcomes and broaden accessibility.
Anal fistula associated mucinous adenocarcinoma with anal fissure: a case report
Authors: Tompe Nikita , Rizvi Shaheen , Sawant Sharadkumar Pralhad
Published: January 2025

Perianal abscesses and anal fistulas are interconnected phases of an infectious process. Persistent irritation and inflammation around an anal fistula can cause cellular changes that increase the risk of cancerous transformation. A long-standing anal fistula, persisting for over 10 years, has been recognized as a potential precursor to fistula-associated mucinous adenocarcinoma (FAMC). A 67-year-old male patient presented with complaints of intense anal pain and a palpable tumor last year. Examination revealed a gluteal abscess, fistula-in-ano and an anal fissure. The patient gave a history of perianal abscess and anal fistula treated three years ago with fistulectomy, pus drainage, and lateral anal sphincterotomy. MRI revealed a horseshoe-shaped, multiseptate abscess in the intersphincteric plane (1 to 9 o’clock, predominantly left-sided), displacing the anal canal to the right, with three intersphincteric fistulas connected to the tumor. Histopathological examination revealed well to moderately differentiated mucinous adenocarcinoma in the distal aspect of the fistula suggesting a direct link between the chronic inflammatory process and development of malignancy. FAMC is a rare but serious complication of chronic anal fistulas. The diagnosis was made three years after treating a perianal abscess, indicating that epithelial dysplasia and carcinogenesis may have begun before the abscess developed. Consequently, FAMC can arise from anal fistulas in fewer than 10 years. This case underscores the importance of careful monitoring of patients with a history of perianal abscesses or anal fistulas for signs of malignant transformation, as early detection can significantly impact prognosis and treatment outcomes.
Phenylephrine causes anuria in a patient with benign prostatic hyperplasia
Authors: Sahu Pratap Kumar , Kumar Dash Mahesh , Kpeno Audifax
Published: January 2025

Phenylephrine is classified as an alpha-adrenergic agonist and used as a nasal decongestant. Benign prostatic hyperplasia (BPH) is a common progressive disease in males over the age of 40, leading to urethral constriction.  Alpha-1A (α1A) receptor blockers such as Silodosin are commonly prescribed to manage BPH symptoms. They relax the smooth muscle around the bladder exit, in the lower urinary tract and prostate gland to facilitate the passage of urine in BPH. However, when combined with alpha-adrenergic agonists such as Phenylephrine, this mechanism may be disrupted. This case report highlights contraindication of Phenylephrine in patients with BPH. It may induce anuria in patients with BPH. We present a case report of a diabetic, hypertensive and hypothyroidism patient with BPH suffering from anuria due to administration of an over-the-counter medicine containing Phenylephrine. Caution should be taken while prescribing Phenylephrine in BPH patients on medication with alpha-1A (α1A) receptor blockers.
Ursodeoxycholic acid induced skin eruption: a case report
Authors: James Anna , M. Indhupriyadharshini , M. Anjali , Premkumar Sivaraman
Published: January 2025

This case report discusses a rare adverse reaction associated with ursodeoxycholic acid (UDCA), highlighting its potential impact on patient management and treatment outcomes. UDCA, commonly used for gallstone dissolution and liver disease, occasionally induces skin eruptions, though mechanisms remain unclear. A 23-year-old male with a history of jaundice and fatty liver presented with a right inguinal hernia. He was prescribed UDCA (300 mg), among other medications, post-surgical intervention. Twelve hours later, he developed sharply demarcated, dusky red plaques on his hands, suggestive of a type IV delayed hypersensitivity reaction. The Naranjo score indicated a probable association between UDCA and the skin eruption. Discontinuation of UDCA led to gradual resolution of symptoms. This case underscores the importance of recognizing and managing rare adverse reactions to UDCA, such as dermatological manifestations. While typically non-life-threatening, these reactions can necessitate treatment discontinuation, potentially compromising therapeutic efficacy. Vigilant monitoring and further research are essential to elucidate underlying mechanisms and optimize patient care strategies.
Pneumococcal pneumonia complicating secondary bacteremia in an immunocompromised patient: a case report
Authors: Datta Sangeeta , Kumar Avinash , Sinha Manish Kumar , Chatarjee Biswaroop
Published: January 2025

Pneumococcal pneumonia is a significant global public health issue, contributing to considerable morbidity and mortality, as well as placing a strain on healthcare systems. Here, we present the case of a 46-year-old female who was admitted to our hospital with a sudden onset of shortness of breath and right-sided substernal chest pain on the day of admission, accompanied by fever and a productive cough. She displayed an increased respiratory rate and diminished vesicular breath sounds, with bilateral scattered rhonchi. Blood tests and chest radiological findings suggested an infectious etiology. Ultimately, Streptococcus pneumoniae was isolated through microbiological culture from both sputum and blood samples, showing similar antimicrobial sensitivity, and appropriate management was initiated. She was discharged after five days of hospitalization, with an uneventful recovery. Appropriate antimicrobial stewardship and pneumococcal vaccination are essential to combat this infection.
A baffling referral from dermatology- aleukemic leukemia cutis with literature review
Authors: Swamy Shruthi , Angadi Veerendra , I. Nandennavar Manjunath , Karpurmath Shashidhar V.
Published: January 2025

Aleukemic leukemia cutis (ALC) is a rather uncommon condition that is characterized by leukemic cell invasion into the skin which primarily precedes the peripheral blood and marrow infiltration by leukemic cells. We present a 35-year-old male with maculopapular skin lesions with a normal bone marrow and peripheral smear. Skin lesions were positive for leukemic cells. Bone marrow infiltration was identified 1 month after the skin diagnosis which showed Acute Myeloid leukemia with Monocytic differentiation. The patient succumbed to tumor lysis syndrome before initiation of treatment. ALC portends a very poor prognosis. Prompt diagnosis with skin biopsy is essential to improve survival in ALC.
The impact of anxiety and depression symptoms on people with multiple cardiovascular risk factors
Authors: Arévalo Karla V. , Suárez Esteven M. , Aldaz Gina G. , Dávila Luis P. , Calderón Jeremy M. , Torres Renato M. , Piedra María F. , Chango Carlos A.
Published: January 2025

Typical cardiovascular risk factors are mainly related to lifestyle. New research suggests that psychological factors, especially anxiety and depression, are closely linked to cardiovascular factors. Anxiety and depression have shown an abysmal increase in the number of people who suffer from them in recent years. Different factors are related to their appearance, among which the social, work, emotional and environmental environment stand out. Multiple studies mention their relationship with cardiovascular risk factors, although there are multiple mechanisms associated with psychological and cardiovascular factors, to date there is no way to measure them. The impact of psychological stress on the development of different cardiovascular factors and its effect on the autonomic nervous system causing its inflammation must be investigated and requires much interest. As such, tools are required to be able to evaluate the biological pathways that link anxiety/depression with the risk of developing cardiovascular diseases.
Artificial intelligence in scientific writing: opportunities and ethical considerations
Authors: Sharma Anil , Rao Praveen , Ahmed Mohammad  Zubair , Chaturvedi Krishnakant
Published: January 2025

Scientific writing is a major consideration when writing a research paper, as it encompasses all aspects of the research. With the rise of digitalization, new opportunities have emerged for the development of Artificial intelligence (AI)-driven tools and algorithms designed to analyze the vast amounts of data being uploaded. It has allowed researchers and practitioners to more efficiently access and evaluate a vast array of scientific papers. This capability facilitates the connection of related studies from the past, identifies research gaps, and speeds up the processes of literature review, evidence generation, and knowledge discovery. Despite these advancements, AI tools are subject to ethical considerations, regulatory approval, compliance with data protection regulations, journal guidelines, transparency, and public perception. Some text prompts are used to instruct AI tools to generate effective information. Fostering trust and transparency with AI tools in scientific writing includes operationalizing frameworks, addressing discrepancies, reducing plagiarism, and generating new innovative ideas. Future trends suggest that AI capabilities will keep advancing and developing, underscoring the need for ethical considerations and the need to balance AI automation with human expertise. However, it cannot replace the creativity and critical thinking skills that are crucial for scientific writing and research. The key objective of this review is to discuss and assess various AI-based tools and algorithms, focusing on their key features and how they can support researchers and authors in enhancing their writing skills.
Role of clarithromycin in the management of multiple infection
Authors: Waghray Pradyut , Bhargava Samir , Joshi Devesh K. , Gala Monil , Muchhala Snehal S. , Kotak Bhavesh P.
Published: January 2025

Clarithromycin, a second-generation semisynthetic macrolide antibiotic, is known for its broad-spectrum antibacterial activity, favorable pharmacokinetic profile, and stability at gastric pH, along with significant anti-inflammatory and immunomodulatory effects. It demonstrates superior efficacy and fewer side effects compared to other macrolides, making it a potent therapeutic option for various bacterial infections. Clarithromycin is approved for use in combination therapy to eradicate Helicobacter pylori and for treating mild to moderately severe respiratory infections such as acute exacerbations of chronic bronchitis (AECB), community-acquired pneumonia (CAP) including infections from Chlamydia, Mycoplasma spp., acute streptococcal pharyngitis, and skin and soft tissue infections. Apart from its usual listed uses, clarithromycin is used in multiple other infections, including upper respiratory tract infections (URTIs) like pharyngitis in penicillin-allergic patients, chronic pharyngitis related to gastroesophageal reflux disease (GERD), sore throat, acute laryngitis, and chronic rhinosinusitis. It is also effective for lower respiratory tract infections (LRTIs) related to chronic obstructive pulmonary disease (COPD), Mycobacterium avium complex (MAC) infections, bronchiectasis, and various other conditions including COVID-19, systemic lupus erythematosus (SLE), bronchiolitis obliterans syndrome post-lung transplant, and H. influenzae infections. During the COVID-19 pandemic, concerns about antimicrobial resistance from the overuse of antibiotics, including azithromycin, highlighted clarithromycin as a preferable alternative due to its superior pharmacodynamics and lower resistance risk. While clarithromycin has a favorable safety profile, it is associated with potential adverse effects such as cardiovascular risks and gastrointestinal disturbances. Its role as a reserve antibiotic highlights its importance in managing resistant infections and in situations where first-line treatments are ineffective or contraindicated.
Cancer-new therapies aligned with Homoeopathy
Authors: Tripathy Tridibesh , Das Shankar , Mohanty Niranjan , Singh D. P. , Dwivedi Rakesh , Tripathy Sanskriti , Tripathy Anjali
Published: January 2025

Cancer is a disease that everyone fears & it is obvious that people are fearful about cancer. The current article discusses various therapeutic interventions of cancer such as R-Cu therapy, CAR-T cell therapy, chronotherapy from the modern system of medicine. It also discusses the homoeopathic intervention in cancer that has medicines on the lines of the R-Cu therapy, CAR-T cell therapy, CRISPR & especially the chronotherapy. The article suggests a treatment protocol based on homoeopathic system of therapeutics aligning with the interventions mentioned above. The application of homoeopathy based on its essential medicine (EM) properties, properties that help the system to cover the masses backed up by a national policy are also discussed in the article. The article aspires that the homoeopathic therapeutic system plays a significant role in dealing with the current non communicable disease menace like cancer in the national level.
Educação em solos
Authors: Costa Falcão Cleire Lima , Falcão Sobrinho José
Published: January 2025

A educação em solos vem ganhando enfoque no ensino da educação básica, por ser o solo o elemento básico da vida das espécies vivas do planeta. É nele que a humanidade retira o seu sustento alimentar. A sua importância no contexto da natureza é eminente, ao ser importante para os nutrientes das plantas e constar em proporcionar armazenamento de água. Neste contexto, o ensino do solo torna-se necessário, assim como torná-lo atrativo para os jovens e adultos. Nesta perspectiva, o presente ensaio fornece elementos sobre a educação em solos em nível teórico, metodológico e prática, contribuindo no despertar de uma consciência ambiental voltada à temática, solo.
The Impact Of Marketing Communications On The Decline Of The De Mata Museum: A Study Of Traditional Wom Vs E-Wom
Authors: Yovita Junijanto Helena , Junaedi Shellyana
Published: January 2025

The main objective of this study was to investigate the influence of marketing communication on visitors' interpretation of the De Mata Museum Yogyakarta site. In total, 196 individuals, ranging in age from 15 to 40, visited the De Mata Museum in Yogyakarta before the conclusion of the investigation. Data was collected using a purposive sample technique, Google Forms and a 5-point Likert scale. The data analysis was performed using IBM SPSS Statistics version 25, which included examining variance (ANOVA) and multiple linear regression. The findings indicated that electronic word-of-mouth (e-WOM) had a more significant influence on a physical site's perceived quality than conventional WOM. Significantly, the influence of commercial electronic word-of-mouth (e-WOM) exceeded that of personal WOM. Furthermore, the impact of negative word-of-mouth (WOM) metrics was markedly more substantial than that of good WOM, and negative electronic word-of-mouth (e-WOM) had a broader influence than negative WOM.