bluuebunny/crossref_metadata_2025 huggingface dataset:
Fracturas osteoporóticas de ramas pélvicas: ¿Son una lesión benigna?
Authors: Angulo Tabernero Marina , Fernández Letamendi Teresa , Hidalgo Mendía Begoña , Ungría Murillo Julia , Gros Bañeres Belen , Fernández Letamendi Nieves , Peguero Bona Antonio
Published: August 2018

Objective: We analized patients treated for osteoporotic rami fractures in our hospital.Methods: We examined the records of patients presenting to the emergency department with osteoporotic low-impact rami fractures. We describe demographic, previously ambulatory ability, diagnosis, associated injuries, comorbility, complications and 1 year mortality.Results: 60 patients (51 women) with a mean age of 83,5 (range, 65,1-99) years had osteoporotic rami fracture. Six patients had previously a rami fracture and 23 a osteoporotic fracture. 27 patients associated other pelvic fracture. Three pacientes had other extrapelvic fracture and six a craneoencephalic trauma. 41 patients had any complication at follow up. Eigth patients (13,3%) were admitted to hospital with a median length of stay in the hospital of 18 days. Eight (13,3%) patients died within 1 year of injury.Conclusions: Low-impact rami fractures affect predominantly elderly women with pre-existing comorbidities. A substantial amount of complications are described in this fractures with a high 1 year mortality. Early rehabilitation therapy with adequate analgesic therapy should be recommended.
Morbilidad de la Enfermedad Pulmonar Obstructiva Crónica en Colombia. Resultados del Estudio SANEPOC-2
Authors: Kuzmar Isaac , Giraldo Ospina Carlos Eduardo , Acevedo Osorio German Oved , Rua Salas Guido
Published: August 2018

Objective: to relate the morbidities of patients belonging to the COPD program of a health institution in Anserma, Caldas (Colombia). Material and Methods: a descriptive study was presented with a sample of 51 patients who underwent exploratory spirometry, the findings were contrasted with the main commodities reported by the patients or the Medical Record through descriptive and inferential statistics. Results: 50% of the evaluated population had at least one recorded comorbidity; the main morbidity found was Arterial Hypertension followed by Chronic Kidney Disease; an associated behavior was found between the GOLD classification and the presence of symptoms with non-statistically significant values; no statistically significant association was found between comorbidities and spirometric values.  Conclusions: new research is needed that clearly values causality in the Colombian population.
Reporte de caso: Trasplante Renal en un paciente con Epidermolisis Bullosa
Authors: Saad Emanuel José , Albertini Ricardo Arturo , Chiurchiu Carlos , Massari Pablo Ulises , De la Fuente Jorge Luis
Published: August 2018

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genodermatosis characterized by abnormalities in the anchoring fibrils which attach the basal cell layer of the epidermis to the underlying structures. A characteristic feature of this disorder is the presence of recurrent blistering or erosions, the result of even minor traction to these tissues. Patients with RDEB frequently develop chronic renal failure, and require renal replacement therapy being a major cause of morbidity and mortality. The role of renal transplantation in these patients is scarcely known.We present the case of an end-stage renal disease patient with RDEB treated by renal transplantation and his follow-up during a period of 83 months after the transplant. In this period, there were very low frequency of serious infections as well as the absence of skin tumors.Renal transplantation could be an alternative to renal replacement therapy in epidermolysis bullosa patients with end-stage renal disease, reducing the comorbidities associated with this treatment.
Rancang Bangun Protipe Aplikasi Berbasis Cloud Computing untuk UKM Jasa Logistik_SAINTEK_2013
Authors: NIRWAN SAEPUDIN
Published: August 2018

Pemanfaatan Teknologi Informasi (TI) di perusahaan jasa logistik skala kecil dan menengah masih sangat minim. Data yang ada menyebutkan bahwa 80% perusahaan jasa logistik lokal di Indonesia belum memanfaatkan TI dalam membantu menjalankan bisnisnya. Penguasaan teknologi informasi dan telekomunikasi ini amat bermanfaat bagi pengembangan internal perusahaan, serta keperluan inter connections dengan pasar dan suppliers. Penguasaan teknologi informasi dan telekomunikasi, sesungguhnya tidak hanya terbatas pada kapabilitas teknis, tetapi juga, yang lebih penting lagi adalah, kaitannya dengan efektifvitas perencanaan dan kemampuan organisasional. Penelitian ini akan mengembangkan aplikasi pergudangan dan distribusi berbasis RFID kemudian dikostumisasi sesuai dengan reference model (blue print) UKM klaster industri Jasa Logistik. Prototipe aplikasi tersebut kemudian di-hosting pada server untuk kemudian dimanfaatkan dengan menggunakan teknologi Cloud Computing oleh perusahaan jasa logistik mitra. Dengan menggunakan teknologi Cloud Computing ini, maka perusahaan jasa logistik skala kecil dan menengah tidak harus mengeluarkan investasi besar dalam bidang TI yang membutuhkan besar.
Tongue Twister as a Bridge to the Gap of Teaching Linguistics and Teaching Literature
Authors: Tungka Novalita Fransisca
Published: August 2018

Tongue twister can be used to stimulate learners’ interest in order to enjoy literary works and to introduce the beauty of language conveyed in it, as well as to bridge the gap between teaching linguistics units and elements of literary works.
Harmonization of Environmental Laws Based On Democracy Justice Principle and Sustainability
Authors: Djanggih Hardianto
Published: August 2018

The Articke Pubish in IOSR Journal Of Humanities And Social Science (IOSR-JHSS), Volume 23, Issue 8, Ver. 3 (August. 2018) PP 54-58Implementation of national development that utilizes natural resources, environmental legislation becomes an important aspect as the legal basis. This research uses normative juridical approach, through the approach of legislation approach, conceptual approach and anlytis approach. Limitations of research on the Inventory of positive law and research on legal system. The result of the research shows that the concept of harmonization of the regulation of the environment in the framework of sustainable development must be based on the principles, theories and philosophies which underlie the formation of a law. It should consider the characteristics of the Indonesian nation so that the rules can be easily implemented
BAHAN AJAR TEKS SASTRA DI KELAS MILENIAL
Authors: Rozak Abdul
Published: August 2018

AbstrakTulisan ini berfokus pada persiapan guru sastra menyelenggarakan pembelajaran yang bermartabat. Posisi guru dalam pembelajaran tidak akan berubah. Guru mempunyai tugas berat, yaitu menjadikan para siswa cerdas menjalankan kehidupan. Guru sastra dapat berkontribusi terhadap pencapaian tujuan pendidikan. Salah satu unsur penting dalam pembelaajran adalah tersedianya bahan ajar yang dapat direspons para siswa. Melalui bahan ajar siswa dapat beraktivitas menuju kehidupan yang lebih baik. Bahan ajar yang disiapkan guru harus memertimbangkan (1) perkembangan teknologi informasi, (2) perkembangan perilaku anak-anak, (3) kehidupan sosial dan budaya, (4) model pembelajaran, (5) media pembelajaran, dan (6) interaksi di kelas. Bahan ajar mutakhir mengantisipasi perkembangan kondisi siswa dan lingkungannya yang didominasi perkembangan teknologi yang sangat pesat. Guru zaman sekarang harus berbicara dengan menggunakan bahasa anak muda. Guru dapat mengikuti perkembang tersebut dengan meningingkatkan kualitas dan kuantitas membaca. Guru sastra adalah guru pembaca trilunan informasi di dunia maya yang terus membesar (big data).
Bridging the gap between transcriptome and connectome
Authors: Fornito Alex , Arnatkeviciute Aurina , Fulcher Ben
Published: August 2018

The recent construction of brain-wide gene expression atlases, which measure the transcriptional activity of thousands of genes in many different anatomical locations, has made it possible to connect spatial variations in gene expression to distributed properties of connectome structure and function. These analyses have revealed that spatial patterning of gene expression and neuronal connectivity are closely linked, following broad spatial gradients that track regional variations in microcircuitry, inter-regional connectivity and functional specialization. Superimposed on these gradients are more specific associations between gene expression and connectome topology that appear conserved across diverse species and resolution scales. These findings highlight the utility of brain-wide gene expression atlases for bridging the gap between molecular function and large-scale connectome organization in health and disease.
EFFECT OF CANDLENUT SHELL AS SUBTITUTE COARSE AGGREGATE TO THE MECHANICAL PROPERTIES OF CONCRETE
Authors: Bachtiar Erniati
Published: August 2018

Concrete construction technology is directed to be sustainable and ecofriendly. The waste of the candlenut shell as a substitute for the coarse aggregate of concrete mixture is known that the candlenut shell has a hard texture so it may be used as a substitute for coarse aggregates in concrete. The purpose of the research was to determine the effect of Candlenut shell as a substitute of coarse aggregate on physical properties (slump test, bleeding, segregation, volume weight) and mechanical properties (compressive strength and tensile strength) of concrete using Candlenut shell as replacement material of the coarse aggregate. The variation of the research was percentage of the Candlenut shell in the concrete mixture, that was 0%, 25%, 50%, 75% and 100% to the coarse aggregate volume in the concrete mixture. Number of specimens in reseach was each 5 pieces each variation. Testing of mechanical properties of concrete (compressive strength and tensile strength) was performed at 28 days. Testing of the concrete for compressive strength test and tensile strength on age 28 days. Concrete using candlenut shell as a substitute of coarse aggregates has decreased compressive strength respectively 11.72 MPa (37.71%) for 25% candlenut shell; 15.54 MPa (50.00%) for 50% candlenut shell; 18.35 MPa (59.02%) for 75% candlenut shell; And 18,85 MPa (60,66%) for 100% candlenut shell from of the 0% candlenut shell with compressive strength of 31.08 Mpa. Concrete using for 25% candlenut shell as a substitute for coarse aggregates decreased tensile strength respectively of 0.95 MPa (28.70%) for 25% candlenut shell; 1.21 MPa (36.56%) for 50% candlenut shell; 1.27 MPa (38.37%) for 75% candlenut shell; And 1.40 MPa (42.30%) for 100% candlenut shell from of the 0% candlenut shell with the tensile strength of BN of 3.31 MPa. The decrease in the value of compressive strength and tensile strength is strongly influenced by the increasing percentage of Candlenut shells on concrete.
Analisis Risiko Usahatani Padi Sawah Metode System of Rice Intensification (SRI) dan Tanam Benih Langsung (Tabela) di Desa Tonusu Kecamatan Pamona Puselemba
Authors: MAMONDOL MARIANNE REYNELDA
Published: August 2018

Penelitian ini bertujuan untuk mengetahui risiko usahatani padi sawah metode System of Rice Intensification (SRI) dan tanam benih langsung (Tabela) di Desa Tonusu Kecamatan Pamona Puselemba Kabupaten Poso. Data dikumpulkan melalui survey yang dilaksanakan dalam bentuk pengisian kuisioner dan wawancara dengan subyek penelitian. Sampel sebanyak 20 orang petani padi sawah diambil dengan menggunakan teknik sampling berstrata, masing-masing strata terdiri dari 10 petani yang menerapkan metode tanam SRI dan 10 petani yang menerapkan metode Tabela. Data dianalisis dengan menggunakan analisis pendapatan, analisis perbedaan produksi, penerimaan, biaya produksi, dan pendapatan pada kedua metode tanam, serta analisis risiko. Hasil penelitian menunjukkan bahwa untuk petani yang menerapkan metode tanam SRI diperoleh rata-rata produksi sebesar 4 ton/ha/MT, rata-rata penerimaan Rp 16.800.000,-/MT, rata-rata biaya produksi Rp 5.615.550,-/MT, dan rata-rata pendapatan Rp 11.196.450,-/MT. Pada petani yang menerapkan metode Tabela diperoleh rata-rata produksi sebesar 2,19 ton/ha/MT, rata-rata penerimaan Rp 6.200.000,-/MT, rata-rata biaya produksi Rp 2.650.150,-/MT, dan rata-rata pendapatan Rp 3.579.850,-/MT. Hasil uji t 2 sampel independen menunjukkan bahwa terdapat perbedaan yang signifikan antara kedua metode penanaman dalam variabel produksi, penerimaan, biaya produksi, dan pendapatan. Koefisien variasi pendapatan petani yang menerapkan metode Tabela lebih besar dibandingkan dengan pada petani yang menerapkan metode SRI. Hasil uji t 2 sampel independen memperlihatkan bahwa terdapat perbedaan antara kedua nilai koefisien variasi, dengan demikian metode Tabela memiliki risiko yang lebih besar terhadap pendapatan petani dibandingkan dengan metode SRI.
From crisis of evidence to a “crisis” of relevance? Incentive-based answers for social psychology’s perennial relevance worries
Authors: Giner-Sorolla Roger
Published: August 2018

Current controversies in social psychology have sparked the promotion of new rules for evidence in the field. This “crisis of evidence” echoes prior concerns from the 1970’s “crisis of social psychology”, with such issues as replication and statistical significance once more under examination. I argue that parallel concerns about the relevance of our research, raised but not completely resolved in the 1970’s crisis, also deserve a fresh look. In particular, the advances made in the current crisis of evidence came about because of changes in academic career incentives--particularly publishing. Today, many voices in psychology urge greater respect for relevance in topics, methods and communication, but the lack of clear and concrete incentives to do so has stood in the way of answers. I diagnose the current incentive structures, propose partial solutions that are within the reach of journal editors and professional societies, and conclude by discussing the links between relevance and evidence, as well as special challenges to the relevance of social psychology post-2016.
On the Reliability of Implicit Measures: Current Practices and Novel Perspectives
Authors: De Schryver Maarten , Hughes Sean , De Houwer Jan , Rosseel Yves
Published: August 2018

During the last two decades a new class of indirect measurement procedures has emerged that has been used widely in psychological science. These procedures were developed in order to circumvent the limitations of self-reports and crack open the hidden world of ‘implicit’ cognition. Yet despite their popularity there seems to be no general framework that constrains (or guides) the way in which we think about the reliability of implicit measures. Instead there are far too many (subjective) researcher degrees of freedom when it comes to deciding how to assess, interpret, and even report reliability. In this paper we introduce such a framework and argue that it can be used by novel and seasoned researchers alike to estimate and interpret the reliability of their implicit measures. Our approach draws on Latent Variable Modeling and the idea of parceling in order to approximate reliability (in the sense of consistency, equivalence, stability) and test the assumptions that underlie those approximations. We close by discussing the implications of our framework for the conceptualization of reliability in particular and for implicit cognition research more generally.
Fiction and History: Polarity and Stylistic Gradience in Late Imperial Chinese Literature
Authors: Vierthaler Paul
Published: August 2018

In late Ming and early Qing China (1550-1700), unofficial historical narratives were extremely popular. At the time, a variety of historical and semi-historical genres flourished, including yeshi 野史 unofficial or wild histories, novels on historical events, and dramas on historical events. These texts form a group of related yet distinct styles of historical writing that I collectively refer to as quasi-histories. This is an umbrella term for a system of texts that contain some historical content but exist in a wide array of genres with different stylistic features and cultural significances.
Intraocular pressure during neurosurgical procedures in context of head position and loss of cerebrospinal fluid
Authors: Czorlich Patrick , Krätzig Theresa , Kluge Nikolas , Skevas Christos , Knospe Volker , Spitzer Martin Stephan , Dreimann Marc , Mende Klaus Christian , Westphal Manfred , Eicker Sven Oliver
Published: August 2018

OBJECTIVE

Perioperative visual loss (POVL) is a rare but serious complication in surgical disciplines, especially in spine surgery. The exact pathophysiology of POVL remains unclear, but elevated intraocular pressure (IOP) is known to be part of it. As POVL is rarely described in patients undergoing intracranial or intradural surgery, the aim of this study was to investigate the course of IOP during neurosurgical procedures with opening of the dura mater and loss of CSF.

METHODS

In this prospective, controlled trial, 64 patients fell into one of 4 groups of 16 patients each. Group A included patients undergoing spine surgery in the prone position, group B patients had intracranial procedures in the prone position, and group C patients were treated for intracranial pathologies in a modified lateral position with the head rotated. In groups A–C, the dura was opened during surgery. Group D patients underwent spine surgeries in the prone position with an intact dura. IOP was measured continuously pre-, peri-, and postoperatively.

RESULTS

In all groups, IOP decreased after induction of anesthesia and increased time dependently after final positioning for the operation. The maximum IOP in group A prior to opening of the dura was 28.6 ± 6.2 mm Hg and decreased to 23.44 ± 4.9 mm Hg directly after dura opening (p < 0.0007). This effect lasted for 30 minutes (23.5 ± 5.6 mm Hg, p = 0.0028); after 60 minutes IOP slowly increased again (24.5 ± 6.3 mm Hg, p = 0.15). In group B, the last measured IOP before CSF loss was 28.1 ± 5.0 mm Hg and decreased to 23.5 ± 6.1 mm Hg (p = 0.0039) after dura opening. A significant IOP decrease in group B lasted at 30 minutes (23.6 ± 6.0 mm Hg, p = 0.0039) and 60 minutes (23.7 ± 6.0 mm Hg, p = 0.0189). In group C, only the lower eye showed a decrease in IOP up to 60 minutes after loss of CSF (opening of dura, p = 0.0007; 30 minutes, p = 0.0477; 60 minutes, p = 0.0243). In group D (control group), IOP remained stable throughout the operation after the patient was prone.

CONCLUSIONS

This study is the first to demonstrate that opening of the dura with loss of CSF during neurosurgical procedures results in a decrease in IOP. This might explain why POVL predominantly occurs in spinal but rarely in intracranial procedures, offers new insight to the pathophysiology of POVL, and provides the basis for further research and treatment of POVL.

German Clinical Trials Register (DRKS) no.: DRKS00007590 (drks.de)
Sagittal alignment of the cervical spine in the setting of adolescent idiopathic scoliosis
Authors: Akbar Michael , Almansour Haidara , Lafage Renaud , Diebo Bassel G. , Wiedenhöfer Bernd , Schwab Frank , Lafage Virginie , Pepke Wojciech
Published: August 2018

OBJECTIVE

The goal of this study was to investigate the impact of thoracic and lumbar alignment on cervical alignment in patients with adolescent idiopathic scoliosis (AIS).

METHODS

Eighty-one patients with AIS who had a Cobb angle > 40° and full-length spine radiographs were included. Radiographs were analyzed using dedicated software to measure pelvic parameters (sacral slope [SS], pelvic incidence [PI], pelvic tilt [PT]); regional parameters (C1 slope, C0–C2 angle, chin-brow vertical angle [CBVA], slope of line of sight [SLS], McRae slope, McGregor slope [MGS], C2–7 [cervical lordosis; CL], C2–7 sagittal vertical axis [SVA], C2–T3, C2–T3 SVA, C2–T1 Harrison measurement [C2–T1 Ha], T1 slope, thoracic kyphosis [TK], lumbar lordosis [LL], and PI-LL mismatch); and global parameters (SVA). Patients were stratified by their lumbar alignment into hyperlordotic (LL > 59.7°) and normolordotic (LL 39.3° to 59.7°) groups and also, based on their thoracic alignment, into hypokyphotic (TK < −33.1°) and normokyphotic (TK −33.1° to −54.9°) groups. Finally, they were grouped based on their global alignment into either an anterior-aligned group or a posterior-aligned group.

RESULTS

The lumbar hyperlordotic group, in comparison to the normolordotic group, had a significantly larger LL, SS, PI (all p < 0.001), and TK (p = 0.014) and a significantly smaller PI-LL mismatch (p = 0.001). Lumbar lordosis had no influence on local cervical parameters.

The thoracic hypokyphotic group had a significantly larger PI-LL mismatch (p < 0.002) and smaller T1 slope (p < 0.001), and was significantly more posteriorly aligned than the normokyphotic group (−15.02 ± 8.04 vs 13.54 ± 6.17 [mean ± SEM], p = 0.006). The patients with hypokyphotic AIS had a kyphotic cervical spine (cervical kyphosis [CK]) (p < 0.001). Furthermore, a posterior-aligned cervical spine in terms of C2–7 SVA (p < 0.006) and C2–T3 SVA (p < 0.001) was observed in the thoracic hypokyphotic group.

Comparing patients in terms of global alignment, the posterior-aligned group had a significantly smaller T1 slope (p < 0.001), without any difference in terms of pelvic, lumbar, and thoracic parameters when compared to the anterior-aligned group. The posterior-aligned group also had a CK (−9.20 ± 1.91 vs 5.21 ± 2.95 [mean ± SEM], p < 0.001) and a more posterior-aligned cervical spine, as measured by C2–7 SVA (p = 0.003) and C2–T3 SVA (p < 0.001).

CONCLUSIONS

Alignment of the cervical spine is closely related to thoracic curvature and global alignment. In patients with AIS, a hypokyphotic thoracic alignment or posterior global alignment was associated with a global cervical kyphosis. Interestingly, upper cervical and cranial parameters were not statistically different in all investigated groups, meaning that the upper cervical spine was not recruited for compensation in order to maintain a horizontal gaze.
The comprehensive anatomical spinal osteotomy and anterior column realignment classification
Authors: Uribe Juan S. , Schwab Frank , Mundis Gregory M. , Xu David S. , Januszewski Jacob , Kanter Adam S. , Okonkwo David O. , Hu Serena S. , Vedat Deviren , Eastlack Robert , Berjano Pedro , Mummaneni Praveen V.
Published: August 2018

OBJECTIVE

Spinal osteotomies and anterior column realignment (ACR) are procedures that allow preservation or restoration of spine lordosis. Variations of these techniques enable different degrees of segmental, regional, and global sagittal realignment. The authors propose a comprehensive anatomical classification system for ACR and its variants based on the level of technical complexity and invasiveness. This serves as a common language and platform to standardize clinical and radiographic outcomes for the utilization of ACR.

METHODS

The proposed classification is based on 6 anatomical grades of ACR, including anterior longitudinal ligament (ALL) release, with varying degrees of posterior column release or osteotomies. Additionally, a surgical approach (anterior, lateral, or posterior) was added. Reliability of the classification was evaluated by an analysis of 16 clinical cases, rated twice by 14 different spine surgeons, and calculation of Fleiss kappa coefficients.

RESULTS

The 6 grades of ACR are as follows: grade A, ALL release with hyperlordotic cage, intact posterior elements; grade 1 (ACR + Schwab grade 1), additional resection of the inferior facet and joint capsule; grade 2 (ACR + Schwab grade 2), additional resection of both superior and inferior facets, interspinous ligament, ligamentum flavum, lamina, and spinous process; grade 3 (ACR + Schwab grade 3), additional adjacent-level 3-column osteotomy including pedicle subtraction osteotomy; grade 4 (ACR + Schwab grade 4), 2-level distal 3-column osteotomy including pedicle subtraction osteotomy and disc space resection; and grade 5 (ACR + Schwab grade 5), complete or partial removal of a vertebral body and both adjacent discs with or without posterior element resection. Intraobserver and interobserver reliability were 97% and 98%, respectively, across the 14-reviewer cohort.

CONCLUSIONS

The proposed anatomical realignment classification provides a consistent description of the various posterior and anterior column release/osteotomies. This reliability study confirmed that the classification is consistent and reproducible across a diverse group of spine surgeons.
Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry
Authors: Kim Irene , Hopson Betsy , Aban Inmaculada , Rizk Elias B. , Dias Mark S. , Bowman Robin , Ackerman Laurie L. , Partington Michael D. , Castillo Heidi , Castillo Jonathan , Peterson Paula R. , Blount Jeffrey P. , Rocque Brandon G.
Published: August 2018

OBJECTIVE

The purpose of this study was to determine the rate of decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry (NSBPR). In addition, the authors explored the variation in rates of Chiari II decompression across NSBPR institutions, examined the relationship between Chiari II decompression and functional lesion level of the myelomeningocele, age, and need for tracheostomy, and they evaluated for temporal trends in rates of Chiari II decompression.

METHODS

The authors queried the NSBPR to identify all individuals with myelomeningocele between 2009 and 2015. Among these patients, they identified individuals who had undergone at least 1 Chiari II decompression as well as those who had undergone tracheostomy. For each participating NSBPR institution, the authors calculated the proportion of patients enrolled at that site who underwent Chiari II decompression. Logistic regression was performed to analyze the relationship between Chiari II decompression, functional lesion level, age at decompression, and history of tracheostomy.

RESULTS

Of 4448 individuals with myelomeningocele identified from 26 institutions, 407 (9.15%) had undergone at least 1 Chiari II decompression. Fifty-one patients had undergone tracheostomy. Logistic regression demonstrated a statistically significant relationship between Chiari II decompression and functional lesion level of the myelomeningocele, with a more rostral lesion level associated with a higher likelihood of posterior fossa decompression. Similarly, children born before 2005 and those with history of tracheostomy had a significantly higher likelihood of Chiari II decompression. There was no association between functional lesion level and need for tracheostomy. However, among those children who underwent Chiari II decompression, the likelihood of also undergoing tracheostomy increased significantly with younger age at decompression.

CONCLUSIONS

The rate of Chiari II decompression in patients with myelomeningocele in the NSBPR is consistent with that in previously published literature. There is a significant relationship between Chiari II decompression and functional lesion level of the myelomeningocele, which has not previously been reported. Younger children who undergo Chiari II decompression are more likely to have undergone tracheostomy. There appears to be a shift away from Chiari II decompression, as children born before 2005 were more likely to undergo Chiari II decompression than those born in 2005 or later.
Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry
Authors: Kim Irene , Hopson Betsy , Aban Inmaculada , Rizk Elias B. , Dias Mark S. , Bowman Robin , Ackerman Laurie L. , Partington Michael D. , Castillo Heidi , Castillo Jonathan , Peterson Paula R. , Blount Jeffrey P. , Rocque Brandon G.
Published: August 2018

OBJECTIVE

Although the majority of patients with myelomeningocele have hydrocephalus, reported rates of hydrocephalus treatment vary widely. The purpose of this study was to determine the rate of surgical treatment for hydrocephalus in patients with myelomeningocele in the National Spina Bifida Patient Registry (NSBPR). In addition, the authors explored the variation in shunting rates across NSBPR institutions, examined the relationship between hydrocephalus, and the functional lesion level of the myelomeningocele, and evaluated for temporal trends in rates of treated hydrocephalus.

METHODS

The authors queried the NSBPR to identify all patients with myelomeningoceles. Individuals were identified as having been treated for hydrocephalus if they had undergone at least 1 hydrocephalus-related operation. For each participating NSBPR institution, the authors calculated the proportion of patients with treated hydrocephalus who were enrolled at that site. Logistic regression was performed to analyze the relationship between hydrocephalus and the functional lesion level of the myelomeningocele and to compare the rate of treated hydrocephalus in children born before 2005 with those born in 2005 or later.

RESULTS

A total of 4448 patients with myelomeningocele were identified from 26 institutions, of whom 3558 patients (79.99%) had undergone at least 1 hydrocephalus-related operation. The rate of treated hydrocephalus ranged from 72% to 96% among institutions enrolling more than 10 patients. This difference in treatment rates between centers was statistically significant (p < 0.001). Insufficient data were available in the NSBPR to analyze reasons for the different rates of hydrocephalus treatment between sites. Multivariate logistic regression demonstrated that more rostral functional lesion levels were associated with higher rates of treated hydrocephalus (p < 0.001) but demonstrated no significant difference in hydrocephalus treatment rates between children born before versus after 2005.

CONCLUSIONS

The rate of hydrocephalus treatment in patients with myelomeningocele in the NSBPR is 79.99%, which is consistent with the rates in previously published literature. The authors’ data demonstrate a clear association between functional lesion level of the myelomeningocele and the need for hydrocephalus treatment.
Pipeline-assisted coil embolization of a large middle cerebral artery pseudoaneurysm in a 9-month-old infant: experience from the youngest flow diversion case
Authors: Colby Geoffrey P. , Jiang Bowen , Bender Matthew T. , Beaty Narlin B. , Westbroek Erick M. , Xu Risheng , Lin Li-Mei , Campos Jessica K. , Tamargo Rafael J. , Huang Judy , Cohen Alan R. , Coon Alexander L.
Published: August 2018

Intracranial aneurysms in the pediatric population are rare entities. The authors recently treated a 9-month-old infant with a 19-mm recurrent, previously ruptured, and coil-embolized left middle cerebral artery (MCA) pseudoaneurysm, which was treated definitively with single-stage Pipeline-assisted coil embolization. The patient was 5 months old when she underwent resection of a left temporal Grade 1 desmoplastic infantile ganglioglioma at an outside institution, which was complicated by left MCA injury with a resultant 9-mm left M1 pseudoaneurysm. Within a month, the patient had two aneurysmal rupture events and underwent emergency craniectomy for decompression and evacuation of subdural hematoma. The pseudoaneurysm initially underwent coil embolization; however, follow-up MR angiography (MRA) revealed aneurysm recanalization with saccular enlargement to 19 mm. The patient underwent successful flow diversion–assisted coil embolization at 9 months of age. At 7 months after the procedure, follow-up MRA showed complete aneurysm occlusion without evidence of in-stent thrombosis or stenosis. Experience with flow diverters in the pediatric population is still in its early phases, with the youngest reported patient being 22 months old. In this paper the authors report the first case of such a technique in an infant, whom they believe to be the youngest patient to undergo cerebral flow diversion treatment.
HISTÓRIAS DE VIDA DE PROFESSORES HOMENS NA EDUCAÇÃO INFANTIL
Authors: Pena Alexandra Coelho
Published: August 2018

Nos últimos anos, vem aumentando a presença masculina no trabalho com crianças de zero a cinco anos, implicando a necessidade de discutir as complexidades que emergem dessa realidade. Pesquisas apontam haver estranhamento, por parte de professores, gestores e familiares, quanto à presença de docentes do sexo masculino, nessa etapa da educação básica, que, histórica e culturalmente, tem estreito laço com o feminino, o materno. O estudo parte de um fenômeno, que se apresenta nas estatísticas, nas pesquisas e no cotidiano de creches e pré-escolas, e o investiga na vida dos sujeitos, na interseção do pessoal com o coletivo. Os entrevistados são professores da Educação Infantil, em instituições privadas e/ou públicas, com diferentes tempos de experiência profissional neste segmento. As histórias de vida destacam-se como metodologia privilegiada para a pesquisa, que traz Martin Buber (2003a, 2003b, 2008, 2009, 2011a, 2011b, 2013), Mikhail Bakhtin (1993, 2011, 2012) e Walter Benjamin (1994, 1995 como referências teóricas, entendendo que as entrevistas potencializam a capacidade de narrar. Uma primeira leitura das entrevistas sugere temas relacionados a dois eixos de análise: histórias de infância e de formação, e histórias relacionadas a questões de gênero.
RELATOS DE EXPERIENCIA, EN BUSCA DE UN SABER PEDAGÓGICO
Authors: Domingos José Contreras
Published: August 2018

Nuestro oficio educativo, como oficio de lo humano, puede ser origen de experiencia, si le prestamos atención a lo que nos pasa y si lo elaboramos y expresamos de un modo apegado a lo vivido, esto es, como narración. Pero como modo de indagación, su propósito no acaba en el registro narrativo, sino que busca hacer visibles y pensables las cuestiones educativas que, a través del narrar, se nos desvelan. Porque en gran medida, el saber pedagógico que necesitamos en tanto que educadores es un saber que pueda vincularse a lo vivido, que pueda nacer de la experiencia, para poder volver a lo que vivimos con más sensibilidad, consciencia y apertura. Con este texto pretendo desarrollar pues estas ideas: que mediante relatos de experiencia indagamos en lo vivido, buscando luz para percibir con más amplitud y orientarnos mejor en el camino de la educación. Pero a la vez, quisiera tantear lo que el título también da a entender: quisiera esbozar algunos relatos de experiencia que me ayuden a exponer el sentido de una investigación educativa preocupada por cultivar un saber pedagógico con el que vivirnos en la relación educativa.
George Butler e a secularização no Maranhão da transição republicana (1885-1892)
Authors: Veras Rogério De Carvalho
Published: August 2018

Trata-se da história do médico e missionário protestante, George William Butler, no período da introdução do protestantismo no Maranhão, em época de transição da Monarquia à República. Embora se conheça a importância da inserção protestante para o processo de laicização do Estado no Brasil, há ainda a necessidade de compreender como essas transformações macrossociais foram vivenciadas no nível microssocial pelos agentes históricos. O objetivo aqui é, a partir da vida deste missionário, entender, sob um novo prisma, as mudanças nos fluxos e refluxos do processo de secularização, no extremo norte do Império. Para tal, serão úteis as contribuições da micro-história, especialmente sua noção de agência e algumas correlações entre insights da antropologia política e acontecimentos da vida de George Butler. Compreende-se que sua trajetória revela as tensões resultantes das coerções e contradições de uma ordem social em crise.
QUESTÕES TEÓRICO-METODOLÓGICAS DA ABORDAGEM (AUTO)BIOGRÁFICA NO VI CIPA
Authors: Sousa Sandra Novais , Assis Jacira Helena do Valle Pereira , Nogueira Eliane Greice Davanço
Published: August 2018

O presente artigo apresenta reflexões sobre as questões teórico-metodológicas e epistemológicas que perpassam a abordagem (auto)biográfica nas pesquisas do campo educacional. Procurou-se fazer uma análise dos dez autores mais citados nos artigos aprovados para comunicação oral, na última edição do CIPA, identificar a qual ou quais linhas epistemológicas estes autores fazem referências, implícita ou explicitamente, em seus escritos, bem como de que forma conceituam os recursos biográficos ou (auto)biográficos em questão: como técnica ou como método de pesquisa. O objetivo foi o de realizar um mapeamento dos direcionamentos epistemológicos dos autores que embasaram teoricamente a produção científica divulgada na última edição do Congresso Internacional de Pesquisa (Auto)biográfica, observando, assim, quais os enfoques privilegiados em cada eixo temático, e se há ou não coincidências entre eles. Como resultados principais, apontamos, por um lado, a diversidade de conceitos e entendimentos dos pesquisadores quanto ao (auto)biográfico, sugerindo uma pluralidade de enfoques epistemológicos, que priorizam ora os aspectos sociológicos, ora os históricos ou psicológicos, no tratamento das narrativas e histórias de vida das pesquisas em educação. Por outro lado, há um número, ainda que reduzido, de pesquisadores que se posicionam epistemologicamente, reivindicando o status de método para o (auto)Qubiográfico.
IDENTIDADE E PROFISSIONALISMO DOCENTE – UMA REVISÃO DA ABORDAGEM NARRATIVA
Authors: Matos Raquel Sofia Dos Santos Macedo
Published: August 2018

Este estudo insere-se num projeto de investigação sobre o desenvolvimento do sentido de identidade e do profissionalismo dos professores no curso das suas vidas. Em forma de estado da arte, propõe analisar de que formas a investigação (auto)biográfica tem contribuído para a construção de conhecimento sobre as questões da identidade e do profissionalismo docente. Nesse sentido, apresenta-se como uma síntese dos trabalhos de natureza empírica realizados sobre estas temáticas, e metodologicamente ancorados na pesquisa biográfica, entre 2005 e 2015, no Brasil e em Portugal. A recolha de dados foi realizada a partir de bases de dados de repositórios científicos dos dois países (OASIS; RCAAP; SCIELO), utilizando como conceitos-chave identidade profissional; narrativas biográficas; histórias de vida e profissionalismo docente. Definimos como critério de seleção dos artigos a publicação em revistas da área da Educação com revisão de pares. Selecionamos e analisamos 17 artigos e 12 teses de doutoramento. Os resultados do estudo manifestam a produtividade das pesquisas (auto)biográficas, quer numa perspetiva de pesquisa quer como práticas de formação. Encontramos e mapeamos uma grande diversidade de referenciais teóricos, de apropriações e aproximações à pesquisa (auto)biográfica, nos investigadores de ambos os países. Encontramos no universo brasileiro um maior número de investigações de caráter interventivo, com o uso de estratégias metodológicas apostadas na construção da identidade dos sujeitos-professores e nas investigações de pesquisa-formação.
PENINGKATAN MOTIVASI DAN HASIL BELAJAR BAHASA INGGRIS MELALUI PENDEKATAN TALULAR PADA SISWA KELAS V SD
Authors: WIJAYANTI SRI
Published: August 2018

AbstrakKurangnya fasilitas yang mendukung dalam proses belajar mengajar merupakansalah satu faktor rendahnya motivasi siswa untuk belajar bahasa Inggris. Hal iniberimbas pula pada rendahnya hasil belajar siswa. Oleh karena itu salah satuupaya yang dapat dilakukan dalam inovasi proses belajar mengajar yaitu denganmenerapkan pendekatan TALULAR (Teaching And Learning Using Locally AvailableResources) yaitu pembelajaran dengan menggunakan sumber-sumber belajar lokalyang tersedia di lingkungan sekitar. Jenis penelitian ini merupakan PenelitianTindakan Kelas yang meliputi empat tahapan penelitian yakni: (1) perencanaan,(2) pelaksanaan, (3) pengamatan, (4) refleksi. Pendekatan TALULAR telah berhasilmeningkatkan motivasi dan hasil belajar bahasa Inggris siswa kelas V SD Negeri 3Sedayu Grobogan. Hasil penelitian menunjukkan ada peningkatan motivasi danhasil belajar sebelum dan sesudah tindakan. Pada siklus I peningkatan motivasimencapai 27.06%, sedangkan rerata kelas meningkat dari 61 menjadi 68.45dengan 67.74% siswa mencapai KKM. Pada siklus II rerata kelas meningkat dari68.45 menjadi 82.07 dengan disertai 83.87% siswa mencapai KKM. Untuk motivasibelajar telah mencapai 75.61%, sehingga telah mencapai target indikatorkeberhasilan yaitu 75%.Kata kunci: motivasi, hasil belajar, pendekatan TALULARAbstractLack of facilities that support the learning process is one of the causes of low studentmotivation to learn English. This is also affecting the low student learning outcomes.Therefore, one of the efforts to be made in innovation learning process byimplementing the approach TALULAR (Teaching And Learning Using LocallyAvailable Resources) is educations using local learning resources available in theneighborhood. This type of research is a classroom action research which includesfour stages of the study are: (1) planning, (2) implementation, (3) observation, (4)reflection. TALULAR approach has succeeded in increasing the motivation andlearning outcomes English fifth grade students of SD Negeri 3 Sedayu Grobogan.Results showed there was an increase in motivation and learning outcomes beforeand after the action. In the first cycle in creased motivation reached 27.06%, whilethe average grade increase of 61 into 68.45 by 67.74% of students achieving KKM. Inthe second cycle increases the average grade of 68.45 into 82.07 by 83.87% ofstudents achieving accompanied KKM. For motivation to learn has reached 75.61%,so it has reached the target indicator of success is 75%.Keywords: motivation, learning outcomes, TALULAR approach
Prodromal Alzheimer’s Disease Demonstrates Increased Errors at a Simple and Automated Anti-Saccade Task
Authors: Holden John G. , Cosnard Alexandre , Laurens Brice , Asselineau Julien , Biotti Damien , Cubizolle Stéphanie , Dupouy Sandrine , Formaglio Maıté , Koric Lejla , Seassau Magali , Tilikete Caroline , Vighetto Alain , Tison François
Published: August 2018

Saccade alterations are potential early signs of Alzheimer’s disease. However, uncertainty persists in how early and reliably automated saccade recording systems detect impairments. This multicenter pathophysiological case-control transversal study explored saccade execution in carefully diagnosed amnestic mild cognitive impairment patients fulfilling research criteria for prodromal Alzheimer’s disease ( n = 29), as compared to both aged-matched mild Alzheimer’s disease patients ( n = 23) and controls ( n = 27). Auto-coded saccades from horizontal (gap) vertical (step) stimulus elicited pro-saccades, and anti-saccade (gap) tasks were compared across the 3 groups. Mild cognitive impairment patients committed significantly more anti-saccade errors compared to controls (46.9 versus 24.3%, p < 0.001). Conventional analyses of the auto-coded stimulus elicited saccades parameters did not distinguish the amnestic mild cognitive impairment from controls or the mild Alzheimer’s disease group. However, an offline analysis of manually coded saccade latencies, using resampling statistics did reveal subtle differences among the groups. Analysis of the manually coded data revealed that the mild Alzheimer’s disease group had a reliably larger self-corrected error-rate than in amnestic mild cognitive impairment and controls ( p = 0.003). Analysis of the manually coded saccade latencies, using more sensitive lognormal bootstrap analysis revealed a continuum, from amnestic mild cognitive impairment to mild Alzheimer’s disease, of an increased severity of impaired inhibition of stimulus elicited saccades and correct voluntary saccade initiation. Anti-saccade error rates and psychometric measures of executive and several other cognitive functions were moderately and negatively correlated. Overall, inhibitory impairments in stimulus elicited saccades, characteristic of Alzheimer’s disease, may be detected early in presumed prodromal patients using a simple, automated anti-saccade task.
Genetically Determined Serum Uric Acid and Alzheimer’s Disease Risk
Authors: Yuan Hongjuan , Yang Wenjie
Published: August 2018

To evaluate whether genetically increased serum uric acid levels influence the risk of Alzheimer’s disease (AD), we used genome-wide significant single nucleotide polymorphisms for uric acid as the instrumental variables, and undertook a Mendelian randomization (MR) study to estimate the effect of uric acid on the risk of AD. The MR method prevents bias due to reverse causation (e.g., uric acid changes because of AD) and minimizes bias due to confounding of both measured and unmeasured confounders. We used the summary statistics from The International Genomics of Alzheimer’s Project Consortium that is the largest AD genome-wide association study of 74,046 individuals of European ethnicity including 25,580 AD cases. We further performed sensitivity analyses to evaluate the assumptions of the MR method. The MR analyses did not support a causal role of genetically elevated serum uric acid on AD risk (odds ratio: 1.02, 95% confidence interval: 0.93–1.12, p = 0.65). Sensitivity analyses, including MR-Egger regression, suggested no strong evidence of bias due to pleiotropy. In conclusion, lifelong genetically increased serum uric acid levels have no protective effect on the risk of AD.
Clinical Experience with Cerebrospinal Fluid Aβ42, Total and Phosphorylated Tau in the Evaluation of 1,016 Individuals for Suspected Dementia
Authors: Tariciotti Leonardo , Casadei Matthew , Honig Lawrence S. , Teich Andrew F. , McKhann II Guy M. , Tosto Giuseppe , Mayeux Richard
Published: August 2018

Background:

Elevated total tau (tTau), 181-phosphorylated phosphorylated tau (pTau), and low amyloid-β42 (Aβ42) in cerebrospinal fluid (CSF) represent a diagnostic biomarker for Alzheimer’s disease (AD).

Objective:

The goal was to determine the overall accuracy of CSF Aβ42, tTau, pTau, and the Aβ42/total tau index (ATI) in a non-research, clinical setting for the diagnosis of AD.

Methods:

From medical records in 1,016 patients that had CSF studies for dementia over a 12-year period (2005 to 2017), we calculated the sensitivity and specificity of CSF Aβ42, tTau, and pTau and the ATI in relation to the final clinical diagnosis.

Results:

Compared with non-demented patients and patients with other dementias or mild cognitive impairment (MCI), the sensitivity and specificity of the recommended ATI and pTau cut-offs (ATI < 1.0 and pTau >61 pg/ml) for the diagnosis of AD were 0.88 and 0.72, respectively. Similar results were obtained comparing AD with non-demented patients only (0.88, 0.82) and AD with other types of dementia (0.81, 0.77). A subgroup of patients with presumed normal pressure hydrocephalus ( n = 154) were biopsied at the time of shunt placement. Using the pathological manifestations of AD as the standard, the sensitivity was 0.83 while the specificity was 0.72.

Conclusions:

In a non-research setting, CSF biomarkers for AD showed a high sensitivity in accordance with previous studies, but modest specificity differentiating AD from other types of dementia or MCI. This study of unselected patients provides a valid and realistic assessment of the diagnostic accuracy of these CSF biomarkers in clinical practice.