bluuebunny/crossref_metadata_2025 huggingface dataset:
Português do Uruguai e português de missiones
Authors: Sturza Eliana Rosa
Published: January 2022

Este artigo propõe uma reflexão sobre o ato de nomear uma língua, considerando-o enquanto um gesto político. Para discutir a nomeação da língua, apresenta-se como objeto de discussão o caso do Português do Uruguai e Português de Missiones. Ambos casos, leva-nos a compreender a relação língua e território e de que modo se constituem os vínculos de pertença com o Brasil, o sentimento de nacionalidade e/ou configuração de novas identidades de falantes imigrantes ou descendentes de imigrantes brasileiros que se deslocaram e habitam, há mais de um século, as zonas fronteiriças do Uruguai e Argentina com o Brasil.
The Influence of Nationalism's Attitude and Tax Morals on Taxpayer Compliance through Tax Awareness
Authors: Tambun Sihar , Haryati Ani
Published: January 2022

The purpose of this study was to examine the direct effect of nationalism and tax morale on tax awareness. As well as testing the effect of the two independent variables on taxpayer compliance through tax awareness. The research method used is quantitative with data collection techniques through questionnaire, method in taking samples using the hair method, namely the number respondent 5 – 10 times the number of indicators. The results of the sample obtained are 180 respondents with the status of Taxpayers. The sample was tested for validity and reliability testing and tested the hypothesis through the Smarts PLS software application. The results of hypothesis testing prove that there is a significant direct effect on nationalism and tax morale on tax awareness, a significant direct effect on tax awareness on taxpayer compliance, and a significant indirect effect on nationalism and tax morale attitudes on taxpayer compliance. Tax through tax awareness. From this research it can be concluded that when the Government will. To increase tax awareness, the first strategy that must be improved is tax morale, then the attitude of nationalism. And to increase taxpayer compliance through tax awareness, the first strategy that must be improved is tax morale, then nationalism.
COVID-19 Salgınının Kadınlarda Eş Uyumu ve Cinsel Yaşam Kalitesine Etkisi
Authors: GÖKBULUT Nilay , BAL Zeynep , UÇAR Tuba
Published: January 2022

ÖZET

AMAÇ: Bu çalışmanın amacı, COVID-19 salgınının kadınlarda eş uyumu ve cinsel yaşam kalitesine etkisini incelemektir.

MATERYAL METOT: İnternet tabanlı kesitsel tipte olan bu çalışma, web tabanlı bir çevrimiçi anket kullanılarak yürütüldü. Araştırmada anket formları 15 Haziran-15 Ağustos 2020 tarihleri arasında sosyal medya aracılığıyla 386 kadına uygulandı. Anket formunda kadınların sosyodemografik özellikleri, COVID-19 pandemisinde cinselliğe ilişkin bilgileri içeren sorular, Yenilenmiş Çift Uyum Ölçeği (YÇUÖ) ve Cinsel Yaşam Kalitesi Ölçeği-Kadın (CYKÖ-K) yer aldı.

BULGULAR: Kadınların %73,8’i COVID-19 pandemisinde eş ilişkilerinin olumsuz etkilenmediğini, %71,8’i cinsel yaşamının olumsuz etkilenmediğini belirtti. Eş ilişkisi ve cinsel yaşamının olumsuz etkilendiğini ifade eden kadınların YÇUÖ toplam, Uzlaşım ve Görüş Birliği alt boyutları puan ortalamalarının, eş ilişkisi ve cinsel yaşamının olumsuz etkilenmediğini ifade eden kadınlardan daha düşük olduğu ve gruplar arasındaki farkın istatistiksel olarak anlamlı olduğu belirlendi (p
A helyi termékek fogyasztói preferenciáinak vizsgálata
Authors: Dr. T. Nagy-Pető Dorka
Published: January 2022

Napjainkban a helyi termékek és a rövid ellátási láncok szerepe felértékelődni látszik. A helyi termékek vásárlásával járó pozitív hatások élénkítik a fogyasztói elköteleződést ezen termékek irányába és a helyi gazdaságokra gyakorolt versenyképességét is. A kutatás a helyi termékekkel kapcsolatos fogyasztói preferenciákat vizsgálja, melyben azon tényezők feltárását végeztem el, amelyek a fogyasztókat alapvetően befolyásolják vásárlási döntéseik meghozatalakor. Nemcsak a helyi termék melletti, de azok vásárlása elleni érveket is számba veszi a kutatás, illetve azt is, hogy a helyi élelmiszerekkel kapcsolatban honnan tájékozódnak és mely típusokat keresik leginkább a helyi termelői piacokon. A kutatás egy országos 500 fős reprezentatív mintán alapul, a mintába kerülők kiválasztása véletlenszerű mintavételi eljárással történt. Az eredmények alapján megállapítható, hogy a származási hely azonosíthatósága, az egészségesség és a helyi termelők támogatása a legfontosabb motiváló tényezők a megkérdezettek körében. Ezenkívül elmondható, hogy az igénybe vett információforrások között kiemelkedő szerep jut a közvetlen kapcsolatoknak – közvetlen referenciaszemélyeknek és a helyi termelőknek, míg a többi forrás alig meghatározó a vásárlási döntések mérlegelésekor. A termelői piacokon bizonyos árucsoportok kiemelkedően népszerűek (zöldség, gyümölcs, tojás), míg más termékkategóriáknál a hagyományos kiskereskedelmi vásárlás a domináns (állati eredetű vagy csomagolt termékek).JEL-kódok: E21, M21, O13
Fascismo no Século XXI?
Authors: Souza Angelita Matos
Published: January 2022

Em 2021, duas obras fundamentais para se entender o fenômeno do fascismo foram lançadas no Brasil: Fascismo e grande capital, de  Daniel Guérin, publicada pela  primeira vez no país, pela Editora da Unicamp; e Fascismo e ditadura, de Nicos Poulantzas, uma reedição muito cuidadosa da Editora Enunciado.
Gravitational Fields and Gravitational Waves
Authors: Yuan Tony
Published: January 2022

The relative velocity between objects with ﬁnite velocity aﬀects the reaction between them. This eﬀect is known as general Doppler eﬀect. The Laser Interferometer Gravitational-Wave Observatory (LIGO) discovered gravitational waves and found their speed to be equal to the speed of light c. Gravitational waves are generated following a disturbance in the gravitational ﬁeld; they aﬀect the gravitational force on an object. Just as light waves are subject to the Doppler eﬀect, so are gravitational waves. This article explores the following research questions concerning gravitational waves: What is the spatial distribution of gravitational waves? Can the speed of a gravitational wave represent the speed of the gravitational ﬁeld (the speed of the action of the gravitational ﬁeld upon the object)? What is the speed of the gravitational ﬁeld? Do gravitational waves caused by the revolution of the Sun aﬀect planetary precession? Can we modify Newton’s gravitational equation through the inﬂuence of gravitational waves?
Detection of Multi-pixel Low Contrast Object on a Real Sea Surface
Authors: Golikov Victor , Samovarov Oleg , Chernomorets Daria , Rodriguez-Blanco Marco
Published: January 2022

The video images captured at long range usually have low contrast floating objects of interest on a sea surface. A comparative experimental study of the statistical characteristics of reflections from floating objects and from the agitated sea surface showed the difference in the correlation and spectral characteristics of these reflections. The functioning of the recently proposed modified matched subspace detector (MMSD) is based on the separation of the observed data spectrum on two subspaces: relatively low and relatively high frequencies. In the literature the MMSD performance has been evaluated in generally and moreover using only a sea model (additive Gaussian background clutter). This paper extends the performance evaluating methodology for low contrast object detection and moreover using only the real sea dataset. This methodology assumes an object of low contrast if the mean and variance of the object and the surrounding background are the same. The paper assumes that the energy spectrum of the object and the sea are different. The paper investigates a scenario in which an artificially created model of a floating object with specified statistical parameters is placed on the surface of a real sea image. The paper compares the efficiency of the classical Matched Subspace Detector (MSD) and MMSD for detecting low-contrast objects on the sea surface. The article analyzes the dependence of the detection probability at a fixed false alarm probability on the difference between the statistical means and variances of a floating object and the surrounding sea.
Were the First Trace Fossils Really Burrows or Could They Have Been Made by Sediment-Displacive Chemosymbiotic Organisms?
Authors: McIlroy Duncan
Published: January 2022

This review asks some hard questions about what the enigmatic graphoglyptid trace fossils are, documents some of their early fossil record from the Ediacaran-Cambrian transition and explores the idea that they may not have been fossils at all. Most researchers have considered the Graphoglyptida to have had a microbial-farming mode of life similar to that proposed for the fractal Ediacaran Rangeomorpha. This begs the question “What are the Graphoglyptida if not the Rangeomorpha persevering” and if so then “What if…?”. This provocative idea has at its roots some fundamental questions about how to distinguish burrows sensu-stricto from the external molds of endobenthic sediment displacive organisms.
Analysis of a Relaxation Process Caused by the Load Variation Adapted on the Basis of Second Order Electrical Model
Authors: Nikishina Guzel , Denisov Evgeny
Published: January 2022

The relaxation process of lithium batteries caused by load variation is considered. It is shown that such processes have strong dependence on internal physical and chemical processes and battery technical conditions. Theoretical expressions of the relaxation process caused by a step-like load variation have been obtained for 1st and 2nd order equivalent electrical circuits. The experimental investigations show that the obtained models fit the real relaxation processes and the behavior of the identified parameters could be explained by specific features of physical and chemical processes within the lithium battery. It should be noted that the obtained results can be generalized for a different type of electrochemical power source. The proposed approach makes it possible to provide means for electrochemical power source characterization and diagnostic, the main advantages of which are good time localization of measurement procedures and inexpensive apparatus implementation.
Immunotherapy for Colorectal Cancer: Mechanisms and Predictive Biomarkers
Authors: Carlsen Lindsey , Huntington Kelsey E. , El-Deiry Wafik S.
Published: January 2022

Though early-stage colorectal cancer has a high 5-year survival rate of 65-92% depending on the specific stage, this probability drops to 13% after the cancer metastasizes. Frontline treatments for colorectal cancer such as chemotherapy and radiation often produce dose-limiting toxicities in patients and acquired resistance in cancer cells. Additional targeted treatments are needed to improve patient outcomes and quality of life. Immunotherapy involves treatment with peptides, cells, antibodies, viruses, or small molecules to engage or train the immune system to kill cancer cells. Preclinical and clinical investigations of immunotherapy for treatment of colorectal cancer including immune checkpoint blockade, adoptive cell therapy, monoclonal antibodies, oncolytic viruses, anti-cancer vaccines, and immune system modulators have been promising, but demonstrate limitations for patients with proficient mismatch repair enzymes. In this review, we discuss preclinical and clinical studies investigating immunotherapy for treatment of colorectal cancer and predictive biomarkers for response to these treatments. We also consider open questions including optimal combination treatments to maximize efficacy, minimize toxicity, and prevent acquired resistance and approaches to sensitize mismatch repair proficient patients to immunotherapy.
PFDA-FMEA-VSM Application for Outsourcing Risk Analysis
Authors: García Aguirre Pedro Angel , Perez-Dominugez Luis , Luviano-Cruz David , Romero-López Roberto , Leon-Castro Ernesto
Published: January 2022

Manufacturing corporations has the acceptance of the Outsourcing Process (OP) to improve industrial activities as well as to archive the revenue objectives, and with this, Risk Analysis (RA) tools are constantly used to assure expected results. Failure Mode and Effect Analysis (FMEA) is one of preferred RA tools, moreover, it is proven that FMEA adds uncertainty because of the human participation at the RA, afterward it is demonstrated that Pythagorean Fuzzy Dimensional Analysis – FMEA – Value Stream Mapping (PFDA-FMEA-VSM) method removes the uncertainty in RA, likewise it aids to the stakeholders for decision making, giving more advantages improving the use of the resources on the project. This document exhibits a real case scenario in a manufacturing firm applying PFDA-FMEA-VSM method adapted for manufacturing OP. The application of PFDA-FMEA-VSM shows solid RA results, removing the human intervention uncertainty added to the risk ranking, gives advantages to the stakeholders for visualize the main risks in detailed diagram, as well as make easier to take better decisions on where to apply resources and mitigate risks during OP.
Biochar Rescues Native Trees in a Global Biodiversity Hotspot
Authors: Sujeeun Leeladarshini , Thomas Sean C.
Published: January 2022

Many tropical invasive species have allelopathic effects that contribute to their success in native plant communities. Pyrolyzed biomass (“biochar”) can sorb toxic compounds, including allelochemicals produced by invasive plants, potentially reducing their inhibitory effects on native species. Strawberry guava (Psidium cattleianum) is among the most important allelopathic invasive species in tropical islands and recognized as the most serious invasive species threat in the global biodiversity hotspot of Mauritius. We investigated the effects of additions of locally produced biochar on native tree species in a field experiment conducted in areas invaded by strawberry guava within Mauritius’ largest national park. Growth and survivorship of native tree species were monitored over 2 ½ years in plots subjected to four treatments: non-weeded, weeded, weeded + 25 t/ha biochar and weeded + 50 t/ha biochar. Native tree growth and survivorship were strongly suppressed by strawberry guava. Biochar treatments dramatically increased native tree performance, with more than a doubling in growth, and substantially increased native tree survivorship and species diversity, while suppressing strawberry guava regeneration, consistent with growth-promoting properties and sorption of allelochemicals. We conclude that biochars, including “sustainable biochars” produced from locally accessible biomass using low-tech pyrolysis systems, have considerable potential to counteract effects of allelopathic invaders and increase the capacity for native species regeneration in tropical island ecosystems.
Exchange rate impacts on international trade
Authors:   Hungarian University of Agriculture and Life Sciences (MATE), Mehtiyev Jalil , Magda Robert ,   Hungarian University of Agriculture and Life Sciences (MATE), Vasa László ,   Széchenyi István University
Published: January 2022

As international trade activities are increased, there are more regulative practices which might be barriers to trade. One of such hindrances is exchange rate volatility that affects trade activities both directly and indirectly. Exchange rate volatility of currencies can affect the trade engagements and as well as the trade balance of a country. One of the implications of the study is that the impacts of monetary policy changes on trade activities can be noticed significantly in the long-term. While impacts on export levels are usually immediate, import levels are changed in long-run. The research analyzes the correlation between inflation and devaluation and clearly states their impacts on trade balance. The case study about devaluation of the currency of Azerbaijan elaborates the impacts of currency volatility on exports which is illustrated and analyzed in this research. Moreover, inflation and devaluation correlations and their impacts on import level of a country are studied through correlation and multiple regression analyses based on the data exported from OECD and World Bank. The results conclude that exchange rate volatility significantly impacts the trade balance in terms of imports and exports. Given the results, exchange rate is a non-trade barrier and affects foreign trade.
Modes of Islamic financing and aggregate economic output: evidence from Islamic banking industry of Pakistan
Authors:   Hungarian University of Agriculture and Life Science, Saleem Adil , Sági Judit ,   Budapest Business School, Bárczi Judit ,   Hungarian University of Agriculture and Life Science
Published: January 2022

With the evolution of Islamic banking, the economic impact of Islamic finance has been studied by many authors. Islamic banks significantly differ from conventional banks in terms of underlying contracts. The asset side of Islamic banks is composed of different modes of financing, which can be categorized at participatory and non-participatory modes of financing. This study aims to examine the relationship of modes of Islamic financing in connection to the real economic output of Pakistan. Using quarterly data from 2005 to 2019, we use autoregressive distributive lag (ARDL) model to analyze the impact of modes of Islamic financing and industrial output. Our findings reveal that non-participatory modes of Islamic financing play a significant role in deriving a healthy aggregate economic output. Therefore, Industrial production found to have a significant positive long run relationship with non-participatory Islamic financing. However, financing modes based on partnership does not have significant impact on total industrial production. The results also show that poor asset quality hinders the production process in the long run and decreases the economic outcome.
Financial literacy programmes targeting the poor: the possibilities of using financial literacy as a tool for financial inclusion
Authors:   Budapest Business School, Győri Zsuzsanna
Published: January 2022

The main aim of this study is to examine the nature of the term financial literacy and link it to opportunities for financial inclusion. The author uses experience of some Hungarian programmes. Financial literacy is the focus of some of them, while in other cases it is just a part of a more complex initiative. After the literature review, the study offers answers for the following research questions: • What are the main characteristics of existing financial literacy programmes in Hungary? • How financial exclusion and the lack of financial literacy are connected in practice? • What are the strengths (achievements) and weaknesses (pitfalls and disadvantages) of existing financial literacy programmes related to the financial inclusion of poor and marginalized social groups? Data from semi-structured in-depth expert interviews, documents and former research papers were collected for identifying Hungarian financial literacy programmes and their existing, missing and potential connections to financial inclusion. Originality of the Research In the literature, there are few articles that connect financial literacy and financial inclusion. Similarly, in practice, financial literacy programmes rarely target the poor. In turn, financial awareness is a very strong prerequisite of financial inclusion, e.g. successful debt settlement for financially vulnerable groups. The findings from the study will enlighten policy-makers, managers of financial institutions and financial inclusion advocates on the importance of special context and complexity of financial literacy programmes provided for the poor.
Trends of standard of living preferences of economics university students as a result of the economic crisis
Authors:   Hungarian University of Agriculture and Life Sciences, Zéman Zoltán , Kálmán Botond ,   Hungarian University of Agriculture and Life Sciences, Bárczi Judit ,   Hungarian University of Agriculture and Life Sciences
Published: January 2022

One of today’s central subject ranges is the theme of personal financial decisions. Standard of living preferences are also closely related to these. The generation that will soon enter the labor market still has these questions in front of them. This is the reason why we focused on university students in our study. We asked Hungarian, Austrian, and Slovak economics students in our questionnaire research. We conducted the study in 2 successive years, in the autumn of 2019 and the autumn of 2020. The first phase of the coronavirus pandemic happened between the two occasions. We examined the received responses along the lines of demographic variables, with the application of linear modelling and decision trees. The year was proven to be the most important variable, which indicates that the crisis caused by the coronavirus had a significant effect on the ideas of students regarding a better standard of living. Our results not only highlight the importance of financial literacy, but also show that personal opinions transform in a crisis regarding the criteria that embody a higher standard of living. It appears that a severe economic crisis increases the sense of responsibility and the importance of future security. Of course, because of the short time that passed, the practical verification of our findings will have to wait.
An IoT measurement solution for continuous indoor environmental quality monitoring for buildings renovation
Authors: Serroni Serena , Arnesano Marco , Violini Luca , Revel Gian Marco
Published: January 2022

The measurement of Indoor Environmental Quality (IEQ) requires the acquisition of multiple quantities regarding thermal comfort and indoor air quality. The IEQ monitoring is essential to investigate the building’s performance, especially when renovation is needed to improve energy efficiency and occupants’ well-being. Thus, IEQ data should be acquired for long periods inside occupied buildings, but traditional measurement solutions could not be adequate. This paper presents the development and application of a non-intrusive and scalable IoT sensing solution for continuous IEQ measurement in occupied buildings during the renovation process. The solution is composed of an IR scanner for mean radiant temperature measurement and a desk node with environmental sensors (air temperature, relative humidity, CO2, PMs). The integration with a BIM-based renovation approach was developed to automatically retrieve building’s data required for sensor configuration and KPIs calculation. The system was installed in a nursery located in Poland to support the renovation process. IEQ performance measured before the intervention revealed issues related to radiant temperature and air quality. Using measured data, interventions were realized to improve the envelope insulation and the occupant’s behaviour. Results from post-renovation measurements showed the IEQ improvement achieved, demonstrating the impact of the sensing solution.
Best Practice Through Broken Triangle, Square and Heart Can Grow Constitutional Awareness and Increase Citizenship Values
Authors: Fatimah Siti
Published: January 2022

This Best Practice is the best experience in learning to increase awareness about constituting and improving learning outcomes through the Broken Square Triangle, Square, and Heart model in Class VIII E of SMP Negeri 2 Wonosari Gunungkidul in the Even Semester of the 2019/2020 Academic Year. The results of the teacher's observations during PBM, students like to littering, wearing colorful shoes, long hair, unidentified uniform at SMPN 2 Wonosari, less respect for teachers in class, not concentrating on teaching and learning activities, sleeping in class. After studying with the Broken Triangle, Square and Heart models, there is a change in constitutional awareness, as evidenced by the research data. At the first meeting with the lecture method, the violation was 18.89%. When KBM uses the Broken Triangle, Square and Heart model, in the second meeting there is a violation of 2.59% and the third meeting there is a violation of 1.48%. This has proven to be an increase in constitutional awareness. From the learning outcomes, the lecture method shows an average result of 59.47, with the Broken Triangle, Square and Heart model, an average of 66.0 and 86.13. Thus, it shows that the Broken Triangle, Square and Heart models are more effectively used in PPKn learning.
New technologies in oral radiology as a diagnostic aid for monostotic fibrous dysplasia: a review
Authors: Torrico-Acha Ximena , Llaguno-Rubio Jhoana Mercedes
Published: January 2022

Monostotic fibrous dysplasia is a benign asymptomatic lesion that affects only one bone, which is replaced by amorphous connective tissue. Clinically there is an increase in the volume of the affected area, which is observed by imaging as a radiopaque area with diffuse non-corticalized limits capable of expanding to neighboring structures, and it is histologically evidenced as “resembling Chinese characters”. The lesion is seen as a radiopaque image with diffuse borders in conventional or digital radiography, while cone beam computed tomography identifies the exact location and extension of an isodense, mixed or hyperdense image of non-corticalized edges. Magnetic resonance imaging is also used when the lesion involves soft tissues or nerves, and bone scintigraphy is performed in order to systemically observe bone quality. The objective of this article was to describe the new technologies in oral radiology for the diagnosis of monostotic fibrous dysplasia and the importance of the current imaging methods in achieving an adequate diagnosis. These techniques range from conventional radiography to bone scans, which provide images of higher quality, clarity and better precision with less invasive techniques to the patient. This review of the literature helps to expand the knowledge of dental professionals in relation to the clinical and imaging characteristics of monostotic fibrous dysplasia.
Microbial Community Shift and Role of Bacteria in Rapid Granulation By Using Diatomite
Authors: Basri Hazlami Fikri , Anuar Aznah Nor , Halim Mohd Hakim Abdul
Published: January 2022

Aerobic granular sludge (AGS) technology is a promising biological method for modern wastewater treatment. However, granulation time have become a major issue for the application of AGS technology especially in low strength wastewater. Recent studies on granulation are focusing towards rapid start-up granulation process. Diatomite, a friable light-coloured sedimentary rock was introduces in this study to enhanced the granules formation. This study highlight the effect of diatomite towards the microbial community during the transformation of seed sludge until development of granules. DNA extraction and Metagenomic analysis was conducted with three samples (seed sludge, control AGS, AGS diatomite) to compare the microbial community. The microbial community analysis revealed the alpha diversity, phylum and class level, and the abundance of EPS producing bacteria of each bacteria samples respectively. Diatomite has a significant influence towards the microbial diversity (High Shannon index alpha diversity). Also, diatomite promotes the abundance of functional bacteria especially EPS producing bacteria, which seen as a crucial elements in granulation process.
Novel Herbal Formulation Jing Si Exhibits Multiple Functions to Inhibit Replication Activity and Subsides Viral Load of COVID-19 Variants
Authors: Lin Yu-Jung , Chiang Chien-Yi , Shibu Marthandam Asokan , Su San-Hua , Dass Kingsley Theras Primus , Lin Pi-Yu , Lin Shinn-Zong , Ho Tsung-Jung , Kuo Wei-Wen , Huang Chih-Yang
Published: January 2022

Background: SARS-CoV-2 is susceptible to frequent mutations and gets transformed into variants therefore identifying novel multi targeting remedies is necessary in formulating strategies to overcome the pandemic. Methods: Traditional Chinese medicine based formula Jing Si herbal (JSH) was screened and analyzed by HPLC to evaluate its ability to act against infection by SARS-CoV-2 variants. The 3CL protease and RdRp assay kit were utilized to detect the enzyme activity. In order to determine the effect of JSH on the binding efficiency and viral penetration of SARS-CoV-2 variants, Calu-3 lung cells and Caco-2 colon cells were infected with fluorescent SARS-CoV-2 pseudo type lentiviruses. In addition, the effect of JSH (16.22 mg /mice/day and 48.66 mg/mice/day) on the viral load in SKH1J mice exposed to inhalation of luminescent SARS-CoV-2 variants for three days was determined. Results: The JSH was found to be effective in inhibiting the viral entry into Calu-3 and Caco-2 cells and in mice pre-treated with JSH for 3 days also inhibited the viral load exposed to different SARS-CoV-2 variants. Interestingly, JSH also decreased 3cL and RdRp activity thereby revealing the multi targeting nature of JSH and therefore will be a potential preventive SARS-CoV-2 infection.Conclusion: Taken together, our present results revealed that JSH could be a potential candidate for COVID-19 treatment.
Clinical Manifestations, Outcomes, and Histopathology of Recurrent Uveitis in Patients Underwent Pupil Coroplasty Combined with Cataract Surgery
Authors: Lu Hui , Chen Doudou , Zhu Siquan
Published: January 2022

Purposes: This study was aimed to evaluate the clinical manifestations of recurrent uveitis in patients underwent pupil coroplasty combined with cataract surgery, and discovery the histopathological changes of iris tissues. Methods: There 28 patients with recurrent uveitis-induced cataract, who had underwent pupil coroplasty, phacoemulsification, and intraocular lens implantation were enrolled in this study. The clinical manifestations and outcomes of the enrolled patients were analyzed. The histopathological changes of iris tissues were observed by hematoxylin and eosin (HE) staining. Results: The uveitis were idiopathic in 89.29% cases (n = 25). Before the surgery, 20 cases had no topical medication for at least 3 months. The preoperative BCVA was > 0.5 in all cases. During the follow-up of 5-10 years, no recurrence of uveitis was found in 96.43% cases (n = 27). Uveitis only recurred in one case along with the onset of ankylosing spondylitis at the 6th week after the surgery. HE staining showed obvious atrophy of iris stroma in all samples. The hyperplasia of pigment cells was observed in the pigment epithelium (n = 9) and even invaded into stroma (n = 19). The infiltration of inflammatory cells in iris tissues was found in 7 cases, and neovascularization in the surface of the iris was found in 2 cases. Conclusion: Recurrent uveitis was characterized by the atrophy of iris stroma, and some cases also exhibited hyperplasia of pigment cells and infiltration of inflammatory cells. The surgery proposed in this study can effectively prevent the long-term recurrence of uveitis.
Bilateral Subthalamic Nucleus Deep Brain Stimulation for Refractory Isolated Cervical Dystonia
Authors: Yin Feng , Zhao Mingming , Yan Xin , Li Tong , Chen Hui , Li Jianguang , Cao Shouming , Guo Hui , Liu Shuang
Published: January 2022

Subthalamic nucleus (STN) deep brain stimulation (DBS) has been proven to be an alternative target choice for refractory isolated cervical dystonia (CD). However, assessments of its short and long-term safety, efficacy, and sustained effectiveness have been limited to few reports. Here, we evaluated nine consecutive refractory isolated CD patients who underwent bilateral STN DBS and accepted to short and long-term follow-up in this retrospective study. Seven time points were used to see the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores (pre-operation [baseline], 1, 3, 6, 12, 24 months post-operation and last follow-up) to assess improvement of dystonic symptoms. The 36-item Short-Form General Health Survey (SF-36) scores obtained at pre-operation and last follow-up to assess the changes in quality of life. All patients tolerated surgery well and acquired observable clinical benefits from STN DBS therapy. All patients achieved a considerable improvement in quality of life at the last follow-up. The hardware-related adverse events can be tolerated and the stimulation-related adverse events can be ameliorated by programming. Our data support the idea that bilateral STN DBS is a safety and effective method for the treatment of refractory isolated CD, with persistent and remarkable improvement in both movement and quality of life.
EGFL6 Promotes Bone Metastasis of Lung Adenocarcinoma by Enhancing Osteoclast Differentiation and Stimulating Cancer Cell Metastasis
Authors: Song Xiaoting , Cheng Xu , Jin Xiangang , Ruan Shengyu , Xu Xianquan , Lu Feng , Wu Xinhui , Lu Fangying , Feng Mingxuan , Zhang Liwei , Ge Renshan , Chen Haixiao , Hong Zhenghua , Hong Dun
Published: January 2022

Background
Lung cancer is still the most fatal cancer today with approximately 30%-40% of these patients will develop bone metastasis. Lung adenocarcinoma (LUAD) is the most common and aggressive type of lung cancer. The relationship between LUAD and bone metastasis and its underlying mechanism remains unclear. This study proved that epidermal growth factor-like domain multiple 6 (EGFL6) was highly expressed in LUAD specimens of patients, and the expression level was positively correlated with bone metastasis of LUAD.
Method
The expression of EGFL6 in cancer tissues was detected by IHC. CCK-8, colony formation assay, migration and invasion assay, wound healing assay, immunocytochemistry, RT-PCR, Western blotting, ELISA, bone resorption, TRAP staining and H&E staining were performed. A nude mouse model of LUAD-induced bone destruction was established by injecting A549 cells in different EGFL6 expression levels.
Results
EGFL6 is elevated in LUAD and is associated with bone metastasis. In vivo, implantation of human adenocarcinoma A549 cells with a higher expression of EGFL6 not only increased tumor growth rate but also bone resorption of tibias in nude mice. In vitro, the secretion of EGFL6 from A549 cells increased osteoclast differentiation but had little effect on osteogenic differentiation. To reveal the underlying mechanism, we demonstrated that EGFL6 enhanced osteoclast differentiation through activating nuclear factor-kappa B (NF-κB) and downstream c-Fos/NFATc1 signaling pathways, and in addition promoted the proliferation, migration and invasion of A549 cells through enhancing the epithelial mesenchymal transformation (EMT) and promoting Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways.
Conclusions
We unveil EGFL6 as a predictor in bone metastasis of LUAD and underscore the relevance of EGFL6 as a therapeutic target.
Comparative plant biochemistry and soil biology of wild and cultivated cotton species
Authors: Waghmare Ritika Rajendra , Velmourougane Kulandaivelu , Blaise Desouza , Harinkhede Lalita Rameshwar , Bansod Pranali Tarachand , Vaidya Jimmy Bhardwaj , Gotmare Vinita P , Prasad Yenumula Gerard
Published: January 2022

Purpose

No attempts were made to analyze the diversity in soil and plant biology of wild cotton species (WCS) and cultivated cotton species (CCS), so far. Our study aimed to understand the differences in soil biological, plant biochemistry, and defense enzyme activities among the ten WCS and four CCS.
Methods

We studied the differences in soil biology, plant biochemistry, and defense enzyme activities among the ten WCS (Gossypium anomalum, G. aridum, G. australe, G. barbosanum, G. capitis-virides, G. davidsonii, G. raimondii, G. somalense, G. stocksii, G. thurberi) and four CCS (G. arboreum, G. herbaceum, G. hirsutum, and G. barbadense).
Results

CCS had 11%, 2%, and 10% higher soil respiration rate, microbial biomass carbon, and microbial metabolic quotient, respectively, compared to WCS. While, WCS had 45%, 15%, and 5% higher glomalin, soil polysaccharide, proteins, respectively, compared to CCS. WCS had 45%, 13%, 8%, and 13% higher acid and alkaline phosphatase, β-glucosidase, and soil dehydrogenase activities, respectively, compared to CCS. WCS had higher carbohydrates in the shoot (40%) and root (27%), while, CCS recorded higher proteins in the shoot (13%) and root (13%). WCS had significantly higher polyphenol oxidase (4% and 15%), peroxidase (30% and 31%), and catalase (36% and 31%) activities in shoots and root tissues, respectively, compared with CCS, while, WCS had higher phenol concentrations (4%) than CCS.
Conclusion

Our study suggests that the difference in soil biological, plant biochemistry, and defense enzyme activities among the WCS and CCS can be attributed to the inherent genetic makeup, which influences consequent plant and soil attributes.
Weakening of the Atlantic Niño variability under global warming
Authors: Crespo Lander
Published: January 2022

The Atlantic Niño is one of the most important tropical patterns of interannual climate variability, with major regional and global impacts. How global warming will influence the Atlantic Niño has been hardly explored, because of large climate model errors. We show for the first time that the state-of-the-art climate models robustly predict that equatorial Atlantic Niño variability will weaken in response to global warming. This is primarily because subsurface and surface temperature variations decouple as the upper equatorial Atlantic Ocean warms. The weakening is predicted by most (>80%) models following the highest emission scenarios in the Coupled Model Intercomparison Project Phases 5 and 6 considered here. These indicate a reduction in variability by the end of the century of 12-17%, and as much as 25% when accounting for model errors. Weaker Atlantic Niño variability will have major consequences for global climate and the skill of seasonal predictions.
Peran Warga Negara dalam Partisipasi Politik di Era Digital melalui SP4N-LAPOR!
Authors: Wicaksono Yudi Krisno
Published: January 2022

Permasalahan penyaluran aspirasi publik secara konvensional adalah suatu tantangan. Media luring nyatanya belum cukup efektif untuk mengakomodasi partisipasi politik publik. SP4N-LAPOR! merupakan jawaban bagi warga negara di Indonesia untuk menyampaikan aduannya secara daring kepada aktor-aktor kebijakan. Sistem yang terintegrasi kepada banyak institusi ini terbukti berimplikasi mempengaruhi keputusan kebijakan. Gap elitis birokrat runtuh menjadi kesan egaliter karena proses politik kebijakan yang nyata melibatkan partisipasi publik. Warga negara sebagai subjek pembangunan di masa kini. Penulis menggunakan metode penelitan riset kepustakaan dalam menjaring berbagai temuan dari berbagai rujukan. Hasil temuan kemudian dijelaskan menggunakan deskriptif kualitatif yang mencoba dielaborasi dengan konsep atau pandangan teoritis.
Sulitnya Orang Indonesia Menerima Kaum LGBT
Authors: Sari Winda Patrika Embun
Published: January 2022

AbstractLGBT (Lesbian, Gay, Bisexual, Transgender) is no stranger to today’s society. Even so, it is known that LGBT people in Indonesia are actually considered as “untruthful” people from various perspectives, both from the point of view of society, religion and law. This article will look at how difficult it is for Indonesians to accept LGBT people. This paper will also look at the theological point of view on LGBT from theories about sexuality and spirituality.

AbstrakLGBT (Lesbian, Gay, Biseksual, Transgender) sudah tidak asing di telinga masyarakat dewasa ini. Meski demikian dikenal, LGBT di Indonesia sebenarnya dianggap sebagai orang “tidak benar” dari berbagai sudut pandang, baik dari sudut pandang masyarakat, agama dan hukum. Tulisan ini akan melihat mengenai masih sulitnya orang Indonesia menerima kaum LGBT. Tulisan ini juga akan melihat sudut pandang secara teologis mengenai LGBT dari teori-teori mengenai seksualitas dan spiritualitas.
Yunus, Labu, dan Kisah Pelariannya!: Melihat Yunus dalam Alkitab dan Surah Yunus dalam Al-Qur’an (Kitab Yunus, QS Yunus: 1-109, QS As-Saffat: 139-148, QS Al-Anbiyaa’: 87-88)
Authors: Saragih Rim Glory Phasah
Published: January 2022

AbstractJonah in the Bible and in the Qur’an is the same character, namely a prophet who was sent by Allah to remind and rebuke the Nineveh people to turn and praise Allah. However, through comparative reading of these texts we will find different narratives about Yunus. But this paper will read both texts in the Bible and the Qur’an so that we can see the richness of the two texts by reading communitarian cross-text over the holy books. There are many things that give us these two texts either from who the Nineveh were in the Qur’an or also Allah’s rebuke to Jonah when he was swallowed by the big fish and how Allah taught through the Pumpkin tree.This article is of course not to prove right or wrong, the main idea of this artile is looking at the appreciative differences in each text and then the main idea is to find broader and deeper meanings related to Yunus and his story. The interpretations of Christian theologians as well as Muslim commentators will offer further explanations about the figure of Yunus in the Bible and in the Qur’an.

AbstrakYunus dalam Alkitab dan dalam Al-Qur’an adalah tokoh yang sama yaitu seorang nabi yang diutus Allah untuk mengingatkan dan menegur orang-orang Niniwe supaya berpaling dan kembali kepada Allah dan memuji Allah. Namun di beberapa bagian ada poin-poin yang berbeda yang disampaikan Alkitab dan juga Al-Qur’an. Tulisan ini akan memperlihatkan dan menyandingkan kedua teks tersebut baik dalam Alkitab dan Al-Qur’an sehingga kita bisa melihat kekayaan dari kedua teks tersebut dengan pembacaan komunitarian lintas teks atas Kitab-kitab suci. Ada hal yang memperkaya kita melalui dua teks ini baik dari siapa itu bangsa Niniwe dalam Al-Qur’an atau juga proses teguran Allah kepada Yunus ketika di telan ikan besar dan bagaimana Allah memberi pengajaran kepadanya melalui pohon Labu. Tulisan ini tentunya bukan bicara benar salah tapi lebih melihat kepada perbedaan apresiatif dalam masing-masing teks dan kemudian penulis menemukan makna yang lebih luas dan lebih mendalam lagi terkait Yunus dan kisahnya. Adapun tafsiran dari teolog Kristen dan juga dari para mufasir Islam akan lebih menjelaskan sosok Yunus dalam Alkitab dan dalam Al-Qur’an.
Keterampilan Berpikir Kritis Siswa SMA Laki-Laki dan Perempuan Pada Program IPA
Authors: Sugiharto Bowo , Azizzah Haifa , Arafa Maretania , Prima Nira Luthfiana , Alifah Nurul
Published: January 2022

Tujuan dilakukannya penelitian ini ialah untuk mengetahui perbedaan keterampilan berpikir kritis siswa laki-laki dan siswa perempuan kelas XI SMAN 5 Surakarta. Penelitian ini termasuk ke dalam penelitian quasi experiment, yaitu non-equivalent control group design. Pengumpulan data dilakukan dengan menggunakan tes berpikir kritis kepada siswa kelas XI SMAN 5 Surakarta. Sampel diambil dengan menggunakan teknik random sampling yang terdiri atas 30 siswa laki-laki dan 30 siswa perempuan dari kelas XI MIPA 1, 2, dan 3 SMAN 5 Surakarta. Penilaian menggunakan rubrik penilaian yang dikembangkan oleh Zubaidah, Aloysius, Mistianah (2015).  Penelitian ini dianalisis dengan menggunakan uji  independence t-test. Analisis data menunjukkan hasil yang signifikan yang berarti terdapat perbedaan antara siswa laki-laki dan siswa perempuan. Kesimpulan dari penelitian ini adalah keterampilan berpikir kritis siswa perempuan lebih tinggi daripada siswa laki-laki.
Assessment of contamination level of a Tanzanian river system with respect to trace metallic elements and their fate in the environment
Authors: Gebreyohannes Netsanet Muluneh , Rwiza Mwemezi J. , Mahene Wilson Leonidas , Machunda Revocatus L.
Published: January 2022

The quality of water and sediments from a marginally-studied river was investigated with respect to As, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn including their fractionation behavior and environmental risk. Samples were collected along the Kou River that flows across two districts in the Manyara region of Tanzania. The leaching behavior of Fe was studied using sequential extraction fractionation and kinetics approach. The Kou water failed to meet the irrigation, aquatic, and biological life standards with respect to one of more trace metallic elements (TMEs). Fe concentration in the river water ranged from 4.1 to 5.38 mg/L, exceeding all the three standards. Six pollution indices were applied to assess the contamination and ecological risks of the nine trace metallic elements in the sediments. Overall, the metals were found to moderately contaminate the sediments. Cr, Fe, and Mn fell under the ‘severely polluted’ sediment quality class. Fe was the only metal that was found to significantly pollute both the river water and sediments. The Fe fractions in the sediments were in the order of residuals>Fe-Mn bound>organic bound>carbonate bound>water soluble>ion exchangeable; 7.8% of the total Fe content was bioavailable with a low potential to leach from the sediments. Under natural conditions, the sharpest release of the non-residual mobile fractions of Fe were identified to occur within the first 24 hours with the maximum Fe leached being 0.14% on the 12th day. None of the metals in the sediments were found with a potential to pose ecological risk.
Performance of rectangular labyrinth weir – an experimental and numerical study
Authors: Ben Said Mosbah , Ouamane Ahmed
Published: January 2022

Labyrinth weirs are commonly used to increase the capacity of existing spillways and provide more efficient spillways for new dams due to their high specific discharge capacity compared to the linear weir. In the present study, an experimental and numerical investigation was conducted to improve the rectangular labyrinth weir performance. In this context, four configurations were tested to evaluate the influence of the entrance shape and alveoli width on its discharge capacity. The experimental models, three models of rectangular labyrinth weir with a rounded entrance and one with a flat entrance, were tested in rectangular channel conditions for inlet width to outlet width ratios (a/b) equal to 0.67, 1 and 1.5. The results indicate that the rounded entrance increases the weir efficiency by up to 5%. A ratio a/b equal to 1.5 leads to an 8 and 18% increase in the discharge capacity compared to a/b ratio equal to 1 and 0.67, respectively. In addition, a numerical simulation was conducted using the open-source Computational Fluid Dynamics (CFD) OpenFOAM to analyze and provide more information about the flow behavior over the tested models. A comparison between the experimental and numerical discharge coefficient was performed and good agreement was found (mean absolute relative error of 4–6%).
Depresión y calidad de vida en adultos mayores que residen en una zona vulnerable en San Martin de Porres
Authors: Quispe Medina Yovana Ysabel
Published: January 2022

Objetivo: Fue determinar la relación entre la depresión y calidad de vida en adultos mayores que residen en una zona vulnerable en San Martin de Porres, Lima – 2021. Materiales y métodos: El presente estudio fue de enfoque cuantitativo, su diseño metodológico fue correlacional-transversal. La muestra estuvo conformada por 130 participantes. La técnica de recolección de datos fue la encuesta y los instrumentos empleados para medir las variables fueron la Escala de Depresión Geriátrica (GDS) y el cuestionario WHOQOL-OLD. Resultados: En cuanto a la hipótesis general, se encontró que existe relación significativa entre la depresión y calidad de vida y (p<0,05). Según las dimensiones, no se encontró relación significativa entre la depresión y la calidad de vida en su dimensión capacidad sensorial (p>0,05); existe relación significativa entre la depresión y la calidad de vida en su dimensión autonomía (p<0,05); no existe relación significativa entre depresión y la calidad de vida en su dimensión actividades pasadas, presentes y futuras (p>0,05); si existe relación significativa entre la depresión y la calidad de vida en su dimensión participación social (p<0,05); si existe relación significativa entre depresión y la calidad de vida en su dimensión muerte/agonía (p<0,05); y finalmente, si existe relación significativa entre depresión y la calidad de vida en su dimensión intimidad (p<0,05). Conclusiones: En cuanto a la hipótesis general se encontró relación significativa directamente proporcional fuerte entre las variables principales.