bluuebunny/crossref_metadata_2025 huggingface dataset:
Early direct skin-to-skin contact between mother and newborn in promoting breastfeeding: A literature review
Authors: Chrysoula Taskou
Published: October 2023

Introduction: Direct skin-to-skin contact (SSC) between a mother and her newborn creates an optimal environment for neonatal adaptation to extrauterine life. Infants who have SSC with their mothers appear to exhibit a more effective breastfeeding pattern. Objective: The aim of this international literature review is to explore the effectiveness of immediate SSC between mother and newborn in the early postpartum hours in promoting breastfeeding. Method: A systematic review of international literature was conducted using the PubMed database with the following keywords: breastfeeding, skin-to-skin contact, newborn, mother, breast-feeding success, and breast-feeding duration. Included studies were required to evaluate the effectiveness of immediate SSC between mother and newborn in promoting breastfeeding. Additionally, studies had to be randomized clinical trials published from 01/01/2010 to 31/8/2020 and written in English. Results: A total of 6 studies were included in the review. The review of these studies indicated that direct skin-to-skin contact between mother and newborn enhances the self-efficacy of maternal breastfeeding, significantly increases the success of initial breastfeeding, and promotes the continuation of exclusive breastfeeding. It was also found to extend the duration of the first breastfeeding session and reduce the time to the initiation of the first feeding. Conclusions: Direct skin-to-skin contact between mother and newborn is an easily accessible method to enhance the self-efficacy of maternal breastfeeding. The high effectiveness of breastfeeding prolongs the duration of exclusive breastfeeding. Healthcare providers should encourage immediate skin-to-skin contact between mother and newborn as a method to increase breastfeeding self-efficacy.
Characteristics of Silkworm Population Growth (Tubifex sp.) at an Average Temperature of 27 °C
Authors: Mashudi Fajri , Thaib Azwar , Nurhayati Nurhayati
Published: October 2023

Silkworms are one of the live feeds given to larvae in the hatchery phase because they have a high nutritional content. Silk worms are relatively small in size that fit into the non-larval mouth so they are easy to digest and easy to catch because of their slow movements. However, the availability of silk worms is still very limited and still relies on nature. So it is necessary to do further culture. Silkworm cultivation is influenced by the food source for growth. In addition to aspects of food, silk worms are also influenced by ecological factors such as temperature. This study aims to determine the characteristics of silkworm population growth (Tubifex sp.) at an average temperature of 27 0C. Data analysis used in this research is descriptive qualitative. The treatment used is at an average temperature of 270C. Based on the research, the highest peak population of silk worms ( Tubifex sp.) was obtained at 27,450C. with an average population of 3060 ind/cm2 and the lowest number of silk worms was found at 27.040C 2477 ind/cm2. The results showed that population growth at 27.450C provided the maximum number of silkworm populations.
Indonesian Hate Speech Detection Using IndoBERTweet and BiLSTM on Twitter
Authors: Kusuma Juanietto Forry , Chowanda Andry
Published: October 2023

Hate speech is an act of speech to spread hate to other people. In this digital era where everyone connects with social media, hate speech is growing rapidly and uncontrollably. Many people do not realize they are giving hate speech when critics something on social media due to a lack of awareness of the difference between hate speech and free speech. The results make victims feel alienated from society, and the people who spread it would often face the law. Detection in the sentences to identify whether it contains hate speech is essential to counter people's ignorance. For detecting such sentences, a machine learning algorithm is widely used to help identify each sentence. In this paper, we used a subset from machine learning named deep learning with the latest IndoBERT model named IndoBERTweet and combined it with RNN layer named BiLSTM. The appearance of IndoBERTweet opened more chances to further improve text classification performance with the addition of BiLSTM layer. The model first made a token representative from the sentence, then calculated it to analyze and made the classification based on the calculation. For this model to be effective, we trained our model with the labeled public dataset retrieved from Twitter. These datasets are classified into hate speech and non-hate speech, and these labels are applied to the models. We evaluated our model and achieved an accuracy of 93.7%, an improvement for classifying hate speech sentences from previous research.
Composition Model of Organic Waste Raw Materials Image-Based To Obtain Charcoal Briquette Energy Potential
Authors: Saptadi Norbertus Tri Suswanto , Suyuti Ansar , Ilham Amil Ahmad , Nurtanio Ingrid
Published: October 2023

Indonesia needs new renewable energy as an alternative to fuel oil. The existence of organic waste is an opportunity to replace oil because it is renewable and contains relatively less air-polluting sulfur. Previous research that has been widely carried out still utilizes coconut shell raw materials, which are increasingly limited in number, so other alternative raw materials are needed. A model is needed to make a formulation that can optimize the composition of organic waste raw materials as a basic ingredient for making briquettes. The research objective was to determine the best raw material composition based on digital image analysis in processing organic waste into briquettes. An artificial intelligence approach with a Convolutional Neural Network (CNN) architecture can predict an effective object detection model. The image analysis results have shown an effective model in the raw material composition of 60% coconut, 20% wood, and 20% adhesive to produce quality biomass briquettes. Briquettes with a higher percentage of coconut will perform better in composition tests than mixed briquettes. The energy obtained from burning briquettes is useful for meeting household fuel needs and meeting micro, small, and medium business industries.
Skew Correction and Image Cleaning Handwriting Recognition Using a Convolutional Neural Network
Authors: Uyun Shofwatul , Rahardyan Seto , Anshari Muhammad
Published: October 2023

Handwriting recognition is a study of Optical Character Recognition (OCR) which has a high level of complexity. In addition, everyone has a unique and inconsistent handwriting style in writing characters upright, affecting recognition success. However, proper pre-processing and classification algorithms affect the success of pattern recognition systems. This paper proposes a pre-processing method for handwriting image recognition using a convolutional neural network (CNN). This study uses public datasets for training and private datasets for testing. This pre-processing consists of three processes: image cleaning, skew correction, and segmentation. These three processes aim to clean the image from unnecessary ink streaks. In addition, to make angle corrections to characters in italics in their writing. The model testing process uses image test data of handwriting that are not straight. There are three images based on the inclination angle: less than 45 degrees, equal to 45 degrees, and more than 45 degrees. Picture cleaning removes unnecessary strokes (noise) from the image using a layer mask, whereas skew correction changes the handwriting to an upright posture based on the detected angle. The pre-processing model we propose worked optimally on handwriting with a skew angle of fewer than 45 degrees and 45 degrees. Our proposed model generally works well for handwriting with fewer than 45 degrees skew with an accuracy of 88,96%.Â Research with a similar scope can continue to improve optimization with a focus on algorithms related to analysis layout studies. Besides that, it can focus more on automation in the segmentation process of each character.
K-Means Clustering Algorithm for Partitioning the Openness Levels of Open Government Data Portals
Authors: Emigawaty Emigawaty , Adi Kusworo , Rochim Adian Fatchur , Warsito Budi , Wibowo Adi
Published: October 2023

More and more local governments in Indonesia are making their data available to the public. This benefits data scientists, researchers, business owners, and other potential users seeking datasets for empirical research and business innovation. However, just because Open Government Data (OGD) portals are accessible does not mean that they necessarily adhere to the established rules and principles of data openness. To evaluate the level of openness of 24 OGD portals in Indonesia, this study used the K-means Clustering algorithm to partition them into three levels: Leaders, Followers, and Beginners. A group of 30 participants, including researchers, data scientists, business enablers, and graduate students, rated the portals on 32 sub-questions related to the eight main principles of data disclosure, focusing on health, population, and education datasets. The study found that eight portals were categorized as Leaders, ten as Followers, and seven as Beginners regarding their level of openness. The study demonstrated that the K-means Clustering algorithm can be effectively used to assess the degree of openness of OGD portals in Indonesia based on eight main principles of data openness. The study recommends increasing the number of OGD portals in eastern territories to supplement the existing case studies in the western and central regions.
Влияние даларгина на поведенческие реакции белых крыс в условиях экспериментального сахарного диабета
Authors: Цибизова Александра Александровна , Сергалиева Мариям Утежановна , Кринцова Татьяна Александровна , Самотруева Марина Александровна
Published: October 2023

Исследование посвящено изучению влияния опиоидного нейропептидного средства даларгина на поведенческие реакции белых крыс с экспериментальным сахарным диабетом в тесте «Порсолт» и «Открытое поле». Эксперименты проведены на белых нелинейных крысах-самцах 8-месячного возраста в количестве 30 особей. Животные были разделены на 3 группы (n = 10): I группа — контрольные особи; II группа — животные с аллоксановым диабетом; III группа — особи с сахарным диабетом, получавшие внутрибрюшинно даларгин в дозе 100 мкг/кг/сут в течение 30 дней, начиная с 21 дня после введения аллоксана. Сахарный диабет моделировали путем введения аллоксана в дозе 100 мкг/кг однократно. Для подтверждения формирования сахарного диабета состояние экспериментальных животных оценивали по следующим показателям: наличие полидипсии и повышенного аппетита, уровень гликемии. На пятые сутки после введения аллоксана было отмечено увеличение количества выпитой жидкости и съеденного корма крысами в группах II и III. На седьмые сутки средний уровень гликемии у этих животных находился в интервале от 10 до 15 ммоль/л; на 14 день — 21 ммоль/л; на 21 день эксперимента — 23 ммоль/л. На фоне гипергликемии у крыс развивалось тревожно-депрессивное состояние, подтверждением чего явилось увеличение времени неподвижности, пассивного плавания в 7 и 42 раза (p ≤ 0,01), снижение латентного периода до иммобильности и времени активного плавания в 4,4 и 1,7 раза (p ≤ 0,01) в тесте «Порсолт»; увеличение таких показателей, как горизонтальная двигательная активность, исследование «норок», фризинга и груминга в 1,35, 1,8, 1,67 и 4,5 (p ≤ 0,01) раза, соответственно, а также уменьшение количества болюсов в 2 раза (p ≤ 0,05) в тесте «Открытое поле». Результаты влияния даларгина на поведенческие реакции животных в условиях экспериментального сахарного диабета показали наличие у исследуемого соединения антидепрессивного действия, выражающегося в коррекции тревожно-депрессивного состояния, что проявлялось в восстановлении показателей двигательной и ориентировочно-исследовательской активности животных: в тесте «Порсолт» увеличение латентного периода до первой иммобилизации и времени активного плавания в 1,25 раза (p ≤ 0,01) и снижение времени пассивного плавания в 1,5 раза (p ≤ 0,01); в тесте «Открытое поле» снижение частоты актов груминга в 1,3 (p ≤ 0,05) раза и горизонтальной и вертикальной активности в 1,28 и 1,83 (p ≤ 0,01) раза, соответственно, увеличение количества болюсов в 1,7 (p ≤ 0,01) раза.
Эмпирическая антибактериальная терапия перитонита
Authors: Затевахин Игорь Иванович , Цициашвили Михаил Шалвович , Яровой Сергей Константинович , Карева Елена Николаевна
Published: October 2023

В статье кратко рассмотрена тактика выбора антибактериального препарата для лечения пациентов с перитонитом в зависимости от формы перитонита и характеристик пациента (состояние печени, почек, аллергоанамнез). Приведено обоснование выбора антибактериального препарата с позиции его фармакодинамики и фармакокинетики. Обсуждены характеристики препаратов стартовой терапии и препаратов резерва при невозможности использования препаратов первого ряда (отсутствие эффекта, непереносимость).
Резистентость S. epidermidis, выделенных из ран пациентов с гнойной инфекцией костей и суставов, к антибактериальным препаратам
Authors: Шипицына Ирина В. , Осипова Елена В.
Published: October 2023

Проведено ретроспективное исследование чувствительности к антибактериальным препаратам штаммов S. epidermidis, выделенных в монокультуре и в составе ассоциаций из очагов инфекции у пациентов с гнойно-воспалительными заболеваниями костей и суставов. Показана резистентность исследуемых клинических изолятов S. epidermidis к амоксициллину (70,5 ± 5,3 %), цефтриаксону (70,2 ± 6,7 %), ампициллину/сулбактаму (69,3 ± 6,5 %). Обнаружено, что 43,5 % штаммов S. epidermidis обладают резистентностью к 6 и более протестированным антибактериальным препаратам. Доля MRSE среди всех штаммов — 51,4 %. Значительную эффективность в отношении штаммов S. epidermidis проявляли рифампицин (95,3 ± 2,9 %), тетрациклин (70,1 ± 7,1 %) и клиндамицин (63,6 ± 1,7 %). Устойчивых к тестируемым антимикробным препаратам изолятов S. epidermidis было больше среди штаммов, полученных из ассоциации бактерий. Отсутствовала эффективность левофлоксацина в отношении 100 % изолятов S. epidermidis, выделенных из ассоциации бактерий, и 40 % бактерий, выделенных в монокультуре при инфекции костей голени. Выявлена высокая эффективность ванкомицина, линезолида и рифампицина в отношении изолятов S. epidermidis, в том числе и MRSE, выделенных как в монокультуре, так и из ассоциации бактерий.
Изучение эффективности даларгина при экспериментальном язвенном колите
Authors: Ляшев Юрий Дмитриевич , Маль Галина Сергеевна , Солин Алексей Владимирович
Published: October 2023

Даларгин вводили подкожно в дозе 100 мкг/кг мышам линии BALB/c с экспериментальным язвенным колитом в течение 7 дней со дня начала моделирования колита. В качестве препарата сравнения использовали сульфасалазин в дозе 200 мг/кг. Установлено, что применение даларгина при язвенном колите оказывало корригирующее действие, что проявлялось следующими изменениями: снижением индекса активности болезни на 7 сут на 28,6 %, уменьшением патологического укорочения толстого кишечника на 31,2 и 23,5 % на 5 и 7 сут, соответственно, снижением распространенности язв (на 46,5 и 59,8 %) и инфильтратов (на 25,4 и 44,2 %) в слизистой оболочке дистального отдела ободочной кишки на 5 и 7 сут (острый колит), уменьшением распространенности инфильтратов на 28 сут на 46,7 % (хронический колит), p ≤ 0,05. При этом фармакологический эффект даларгина был выше, чем у сульфасалазина, что подтверждается уменьшением патологического укорочения толстого кишечника на 16,2 и 15,9 % на 5 и 7 сут, снижением распространенности язв на 17,4 % на 7 сут и инфильтратов на 21,2 и 31,3 % на 5 и 28 сут у мышей с экспериментальным язвенным колитом. Выявленное действие даларгина может быть обусловлено ранее описанными свойствами: усилением продукции антиапоптического фактора Bcl-xl, угнетением секреции провоспалительных цитокинов и NF-kB, антиоксидантным и иммуномодулирующим действием препарата.
Sosyal Bilgiler Öğretmenlerinin Uzaktan Eğitim İle Tarih Konularının Öğretimine İlişkin Deneyimleri: Fenomenolojik Bir Çalışma
Authors: YILMAZ Kaya , AKCAN Ceylan
Published: October 2023

Covid 19 salgını ile ortaya çıkan pandemi nedeniyle eğitim ve öğretim tüm dünyada olduğu gibi ülkemizde de ilkokuldan yüksekokula kadar eğitim ve öğretimin her kademesinde uzaktan eğitimle yapılmıştır. Bu çalışma, Sosyal Bilgiler öğretmenlerinin uzaktan eğitim sürecinde tarih konularının öğretimine yönelik deneyimlerine yükledikleri anlamı ortaya çıkarmak amacıyla yapılmıştır. Çalışma, nitel araştırma yöntemlerinden betimleyici fenomenolojik araştırma deseni ile yürütülmüştür. Gaziantep İlinin farklı okullarında görev yapan 12 Sosyal Bilgiler öğretmeni çalışmanın katılımcılarını oluşturmaktadır. Öğretmenlerin seçiminde amaçlı örneklem, verilerin toplamasında ise yarı yapılandırılmış görüşme tekniği kullanılmıştır. Verilerin analizinde betimleyici fenomenolojik araştırma deseninin kendine özgü dört aşamalı çözümleme süreci kullanılmıştır. Bu aşamalar, 1.parantezleme, 2. fenomenolojik redüksiyon, 3. imgesel çeşitleme ve 4. anlam ve özlerin sentezlenmesi’dir. Analiz neticesinde, uzaktan eğitim sürecinde Sosyal Bilgiler dersinde tarih konularının öğretiminde öğretmenlerin deneyimlerinin yapısını ve özünü oluşturan altı bileşen tespit edilmiştir. Öğretmenlerin deneyimlerinin yapısını ve özünü oluşturam bu bileşenler şunlardır: (1) Sanal ortamda soyut tarihi kavramların öğretiminde ve somutlaştırılmasında zorluk yaşama, (2) teknolojiye erişim ve kaynak sorunu ile karşılaşma, (3) öğrencilerin derse karşı ilgilerini ve motivasyonlarını arttırma çabasına girme, (4) canlı derslerde iletişim ve etkileşim problemleri yaşama, (5) öğrencilerin derse karşı ilgilerinin ve katılımlarının yetersiz olması, ve (6) daha fazla dijital materyal ve kaynak kullanma zorunluluğudur. Öğretmenlerin öğrencilerin derse dikkatlerini çekmek, derse karşı ilgilerini artırmak ve dersi eğlenceli hale getirmek için gayret ettikleri de belirlenmiştir.
Blebbing of the plasma membrane of lymphocytes as a marker of endothelial dysfunction in the development of post-resection insufficiency in patients with focal liver lesions
Authors: Dunayevskaya S. S. , Malinovskaya N. A. , Kosik A. A.
Published: October 2023

Purpose of the study. To evaluate the intensity of blebbing of the plasma membrane of lymphocytes and the formation of microparticles of lymphocytic origin in patients with postresection hepatic failure. Material and methods. The study involved 54 patients with focal liver diseases. The study involved 32 (59%) women, 22 (41%) men. The average age was 59.5 [49.75; 66,00]. Patients were divided into groups, 1 group - 10 patients with developed acute liver failure and 2 group - 44 patients with a favorable course of postoperative period. The following surgical interventions were performed: 36 (67%) patients underwent surgery - laparotomy, segmental liver resection, 10 (18%) - left-sided hemihepatectomy and 8 (15%) - right-sided hemihepatectomy. Results. Predictors of early postoperative hepatic failure are a decrease in initial blebbing and an increase in terminal blebbing and free microparticles of lymphocytic origin. Conclusions. Thus, changes in lymphocyte blebbing and the presence of free microparticles of lymphocytic origin are due to the development of endothelial insufficiency and apoptosis of lymphocytes in the context of liver failure and are determined by the reduced function of residual liver volume.
Changes in the expression of oxidative stress genes in toxic hepatitis of different etiologies and their correction
Authors: Yakupova T. G. , Karimov D. O. , Bakirov A. B.
Published: October 2023

The study aims to study of changes in transcriptional activity of oxidative stress genes in acute toxic hepatitis. Materials and methods. The study material was white mongrel male rats weighing 180-200 grams. The studied toxicants were: carbon tetrachloride, ethanol, acetaminophen. As hepatoprotectors were introduced: oxymethyluracil, ademethionine and ethylmethylhydroxypyridine succinate. RNA was isolated, which was subjected to reverse transcription. RT-PCR was performed using a real-time PCR system in the presence of SYBR Green. GAPDH was used as a normalized control. The expression of the studied genes was evaluated by PCR analysis using pre-selected primers. Statistical significance was checked using IBM SPSS Statistics software. Results. In comparison of experimental groups, statistically significant differences were found in the level of expression of the CASP7 gene. Transcriptional activity of the CHEK gene (k=11.25; p=0.024). The GCLC gene (k=21.70; p=0.001) reached its minimum value of -3.6 [-3.72; -3.32] in the Mexidol group. The multiplicity of expression of the GSTM1 gene (k=15.54; p=0.004) had the highest value -0.14 [-1.11; 1] in the group that did not receive TCM. The NQO1 gene achieved its statistical significance in a 72-hour experiment (p=0.005). Statistical analysis of the RIPK gene showed significant differences. The expression level of the GSTP1 gene (k=10.39; p=0.034) reached its maximum value in the untreated group of 0.03 [-0.74; 0.48]. Expression of the NFE2L2 gene with acetaminophen administration showed the following results (k=13.64; p=0.009). Glutathione activity (k=10.29; p=0.036) reached its minimum value in the group receiving Mexidol -1.6 [-1.7; -1.29]. The multiplicity of superoxide dismutase expression showed statistical significance (p=0.003). Conclusions. Markers of the clinical course, prognosis and outcomes of toxic hepatitis were found. These data make it possible to determine the severity of the disease at the stage of early molecular response, when active clinical symptoms have not yet developed, which makes it possible to prescribe targeted therapy and adjust treatment tactics.
The development of liver cirrhosis in a patient taking long-term weight loss supplements
Authors: Goma T. V. , Kozlova N. M. , Boldyreva K. S.
Published: October 2023

Dietary supplements are often self-administered by patients for weight loss. However, the hepatotoxicity of such supplements remains underestimated. Liver damage is diverse: from asymptomatic reversible course to lethal fulminant hepatitis. In the case of a long unrecognized course and prolonged use of dietary supplements, irreversible structural and functional damage to the organ occurs. We present a retrospective analysis of the case histories of a patient with liver cirrhosis, who has a long history of using dietary supplements of Thai and Chinese origin, hellebore extract, during 5 years of follow-up. Despite the discontinuation of weight loss drugs, regular complex therapy, the patient has a steady progressive course of the disease. Obese patients with an increased risk of liver damage require a dynamic assessment of liver function, not only when prescribing drugs, but also when using various dietary supplements.
Differential diagnosis of unconjugated hyperbilirubinemiadetected after coronary artery stenting
Authors: Chepurnenko S. A. , Nasytko A. D. , Shavkuta G. V.
Published: October 2023

Introduction. An increase in bilirubin and liver enzyme activity may be one of the side effects of statin therapy, often occurring in patients after AMI and coronary artery stenting, or in high and very high risk individuals on high and moderate intensity statin therapy. The frequency of occurrence of increased transaminases and bilirubin is according to different authors. Therefore, in terms of differential diagnosis, the cardiologist should consider Gilbert’s syndrome as a possible cause of hyperbilirubinemia. Description of the clinical case. The article considers a clinical case of differential diagnosis of non-conjugated hyperbilirubinemia detected in a patient after coronary artery stenting. The level of hemoglobin, erythrocytes, reticulocytes did not differ from normal values and did not change over time. This made it possible to exclude the hemolytic genesis of hyperbilirubinemia. Genetic testing was used to establish the homozygous form of Gilbert’s syndrome. However, the presence of fibrotic changes in the liver, an increase in not only unconjugated, but also conjugated bilirubin, hypertriglyceridemia, dyslipidemia, and stenosing atherosclerosis of the coronary arteries did not allow us to state that the patient had only Gilbert’s syndrome. Discussion. According to recent studies, this disease is characterized by a benign course and reduces the risk of developing cardiovascular diseases due to the antioxidant effect of bilirubin. In addition to Gilbert’s syndrome, the patient was diagnosed with an erased form of non-alcoholic fatty liver disease associated with metabolic syndrome. Conclusion. The disease was caused by insulin resistance, a high-calorie diet, excess consumption of saturated fats, refined carbohydrates, and a sedentary lifestyle. The drugs of choice in this case are statins, ezetemibe, and ursodeoxycholic acid. Their appointment allows not only to reduce cardiovascular risk, but also to slow down the further progression of liver fibrosis.
The debut of autoimmune hepatitis after a new coronavirus infection (COVID-19) in an 11-month-old child
Authors: Lebedeva T. N. , Marchukova A. U. , Bondar K. G.
Published: October 2023

In many countries fix cases of severe liver damage in children are recorded. A previous or existing coronavirus infection leads to a disruption in the body’s immune response to infections, which can lead to severe inflammation that caused liver damage. This article describes a clinical case of type 2 autoimmune hepatitis, a high degree of biochemical activity, that debuted in an 11-month-old child after a new coronavirus infection (COVID-19). The presented clinical example demonstrates the need for a thorough and comprehensive examination of children with the first clinical manifestations of liver damage and timely prescription of therapy
Hyperammonemia in patients with stable angina pectoris and nonalcoholic fatty liver disease at the steatosis stage
Authors: Zykina E. J. , Simonova Zh. G.
Published: October 2023

The aim. To assess the severity of hyperammoniemia in patients with non-alcoholic fatty liver disease at the steatosis stage in conditions of comorbidity with stable angina. Research materials and methods. During the clinical trial, three groups of patients with stable angina were formed. Group I (n = 43) consisted of patients with NAFLD at the stage of hepatic steatosis in combination with obesity and a stable form of CHD. Group II (n = 41) - patients with NAFLD at the stage of hepatic steatosis against the background of normal body weight and stable CHD. Group III (control) (n = 42) - patients with stable angina without NAFLD, with normal body weight. The results of laboratory examination (clinical and biochemical blood tests, lipidograms, insulin levels (calculated by HOMA-IR), glycosylated hemoglobin (HbAlc)) were evaluated; non-invasive markers for the diagnosis of liver injury. Hyperammonemia was evaluated by quantitative rapid ammonia analysis using a Pocket Chem TM BA PA-4140 analyzer. All patients underwent ultrasound of the liver using Philips Epiq 5 (USA). Results. In all patients with stable angina (group I and II), the diagnosis of non-alcoholic fatty liver disease, steatosis stage, was confirmed. The lipid profile of patients in Groups I and II showed more significant hypertriglyceridemia compared to those in the control group, with no statistical difference in Groups I and II. The mean ammonium level in patients with NAFLD in combination with stable CHD (group I, II) was above the threshold and was 87 (57-127.5) and 79 (57-97) μmol/L, respectively, and did not differ significantly (p > 0.05). In patients of group III (without liver disease), the mean values of ammonia in the blood were in the target range. According to the results of correlation analysis, we established the relationship of ammonium with liver enzymes, calculated steatosis indices and basic metabolic indicators. Conclusion. Patients with non-alcoholic fatty liver disease in the steatosis stage with a combination of stable angina have more severe hyperammonemia compared to patients with stable CHD without concomitant liver injury.
Evaluation of Hyperammonemia and Cognitive Impairment in post-COVID patients
Authors: Mukhametova D. D. , Belousova E. N. , Fashieva Z. I. , Nazarova M. G. , Knyazeva M. V. , Abdulganieva D. I.
Published: October 2023

The paper presents the results of an assessment cognitive function and ammonium levels in individuals who have had a novel coronavirus infection (COVID-19). The study included 60 people: 41 - confirmed COVID-19 during last 3 months and 19 - the control group. There have been performed clinical examination, psychometric test - connect-the-numbers test (CNT) and Mini-Mental State Examination (MMSE). Blood ammonium level has been determined. Post-COVID-19 syndrome (PCS) was diagnosed in 70.7% of patients, which was manifested by complaints of memory loss, weakness and anxiety. In patients who underwent COVID-19, cognitive impairment was detected on the MMSE scale in 27 people (45%), and the changes were more pronounced in the group with PCS. In the post-COVID group, 66% of the subjects had an increase CNT result. The cognitive impairment according to the MMSE correlated with the CNT results. Hyperammonemia was found in 54% of COVID-19 survivors, with higher values observed in the PCS group. No correlation was found between hyperammonemia and cognitive impairment.
Comparative analysis of methods for evaluating myocardial hypertrophy in children with arterial hypertension
Authors: Pavlinova E. B. , Lippert V. N. , Dakuko A. N.
Published: October 2023

Relevance: over the past decades, the prevalence of arterial hypertension (AH) in the pediatric population has increased significantly, but there are still many open questions related to the diagnosis and course of the disease, the validity of the choice of antihypertensive therapy and the risks of target organ injury. In clinical practice, patients with hypertension are observed by a team of specialists of various profiles, and a unified approach to managing the disease is not always formed between them. Underestimation of risk factors, late detection of target organ injury and untimely start of antihypertensive therapy significantly increase the risks of an unfavorable, progressive course of the disease, aggravating the further prognosis. Strict adherence to the methods of diagnosing the disease and its potential consequences recommended by the professional community of pediatric cardiologists ensures an adequate initiation of drug therapy, which allows not only to control the course of hypertension, but also to prevent the development of long-term complications. Objective: to analyze the indicators obtained using the formula recommended by pediatric cardiologists compared to the routine method for detecting left ventricular myocardial remodeling in children with AH. Materials and methods: a cross-sectional, cohort, non-randomized study, which included 92 patients with newly diagnosed primary arterial hypertension, who were not receiving antihypertensive therapy at the time of the examination. The standard linear dimensions of the walls and cavities of the heart were assessed during echocardiography. The results were evaluated by the standard Fisher’s test, the xi2 test in the Statistica 9 software. The sample excluded children-athletes, patients with secondary hypertension, overweight, congenital heart disease and cardiomyopathy. All children were tested the same according to the current Federal Clinical Guidelines “Diagnosis and treatment of arterial hypertension in children and adolescents”. Results: the usage of the recommended formula is not only significantly more often allowed to identify the early stages of LV myocardial hypertrophy, but has great sensitivity. The routine method for calculating LV remodeling showed the norm much more often even in case of severe violation of the geometry of the heart. Conclusion: untimely detection of LV myocardial hypertrophy leads to late initiation of antihypertensive therapy, underestimation of risk factors, which increases the risk of an unfavorable course of the disease and the occurrence of long-term cardiovascular complications at a young age.
The state of psycho-emotional status in adolescent children with chronic gastroduodenitis, associated with Helicobacter pylori infection in the period of exacerbation and remission
Authors: Gurova M. M.
Published: October 2023

Relevance. In the pathogenesis of chronic gastroduodenitis, along with an infectious factor (Helicobacter Pylori infection), an important role is played by the state of the patient’s psycho-emotional status, which is characterized by a high incidence of anxiety and subdepressive states in adolescence. Goals: to assess the state of the psycho-emotional status and quality of life in adolescent children with chronic gastroduodenitis associated with Helicobacter pylori infection in the period of exacerbation, after 1 month and 6 months after successful eradication therapy. Materials and methods. The prospective case-control study included 60 adolescent children with morphologically proven chronic gastroduodenitis associated with Helicobacter pylori infection (main group) in the period of exacerbation, in 1 month. and 6 months. after successful eradication therapy. As a comparison group, 22 schoolchildren with the first health group were taken, comparable in age and gender with the children of the main group. All children underwent psychological testing (Spielberger test to assess the levels of reactive and personal anxiety, Zung test to determine the level of depression) and assessed the quality of life. Results. During the period of remission, more than half of the children with chronic gastroduodenitis had complaints common for asthenic syndrome: weakness, mental exhaustion, and headaches. In the period of exacerbation, the highest rates were noted on the scales of personal and reactive anxiety, depression, followed by improvement during treatment and worsening of indicators after 6 months after eradication therapy. Quality of life indicators, characterized by improvement after eradication therapy, after 6 months. showed a statistically significant decrease on the scales of physical functioning (RP), general health (GH), vitality (VT) and mental health (MH). Conclusion: Adolescent children with chronic gastroduodenitis characterized by changes in the psycho-emotional status in the form of subdepression and increased anxiety, both reactive and personal. These changes are not completely stopped after the use of traditional therapy for chronic gastroduodenitis and persist in the period of remission, worsening the quality of life, increasing the negative perception of the disease and treatment prospects.
Refiding syndrome and spontaneous pneumomediastinum in a teenage girl with anorexia nervosa
Authors: Ilenkova N. A. , Chikunov V. V. , Alekseeva O. V.
Published: October 2023

Anorexia nervosa is a syndrome associated with a deliberate decrease in body weight caused and / or maintained by the patient himself through a sharp restriction of the amount of food taken up to complete rejection of it, an obsessive fear of weight gain. The article describes a clinical case of a 15-year-old girl with anorexia nervosa and the development of severe protein-calorie deficiency, refiding syndrome and spontaneous pneumomediastinum, which required intensive therapy. The clinical features of the course of the disease and observation of the patient in dynamics are presented. Following modern clinical guidelines helped to identify complications in a timely manner, streamline diagnostic tactics, establish a diagnosis and determine the necessary therapy. The alertness of specialists regarding the appearance of complications, against the background of this eating disorder, will allow timely establishing the correct diagnosis, determining approaches to choosing a method of nutrition, tactics for expanding the diet, as well as drug correction of existing conditions.
A clinical case of plastic bronchitis on the background of community-accombined pneumonia
Authors: Sheitanidi L. L. , Krivonogova N. N. , Bachieva L. I. , Dolbnya S. V. , Klimov L. Ya.
Published: October 2023

Plastic bronchitis (PB) is a rare acute respiratory disease characterized by the formation of fibrin-rich plugs leading to airway obstruction and respiratory failure. This is due to the organization of the exudate, or transudate, which takes the form of the airways. Mortality in BE reaches 28-60% in patients with congenital heart disease (CHD) and 6-7% among other causes. Exact epidemiological data are unknown. In most patients, BE occurs in the context of underlying diseases, which can be conditionally divided into two groups: diseases of the heart and blood vessels and a secondary complication of pulmonary diseases. Clinical manifestations of PB are manifested by episodes of dyspnea, tachycardia, hypoxia, fever, and cough associated with airway obstruction. All existing treatments are symptomatic. The article presents a clinical case of the development and course of PB in a girl aged 1 year and 10 months against the background of acute community-acquired right-sided segmental (S10) pneumonia.
Pre-owned car price prediction by employing machine learning techniques
Authors:   Department of Computer Applications, Techno Main Saltlake, Kolkata, India, Nandan Mauparna , Ghosh Debolina ,   Department of Information Technology, Haldia Institute of Technology, Haldia, India
Published: October 2023

Pre-owned automobiles including cars are becoming incredibly popular. There has been a steady increase in automobile production namely, passenger cars over the preceding decade with more than 70 million passenger cars being manufactured in 2016 itself. This has given rise to the resale automobile market, which has become a thriving business in its own right. Customers who are interested in purchasing a pre-owned car frequently face the difficulty in locating a vehicle that fits within their financial constraints as well as estimating the price of a specific pre-owned car. Customers can make more educated decisions regarding the purchase of a pre-owned car if they have access to accurate price projections for pre-owned cars. With the proliferation of digital marketplaces, both the buyer and the seller remain more updated regarding the recent market trends and patterns that impact the value of a used car. In this paper, we investigate this issue and propose a forecasting system using machine learning techniques that enables a prospective buyer to anticipate the price of a pre-owned vehicle of interest. The process is conducted with the collection and pre-processing of a dataset followed by an exploratory data analysis. Various machine learning regression techniques, such as Linear Regression, LASSO (Least Absolute Shrinkage and Selection Operator) Regression, Decision Tree, Random Forest, and Extreme Gradient Boosting, have subsequently been implemented. The techniques are then compared so as to determine an optimal solution. Three types of errors namely, MAE, MSE and RMSE have also been calculated in order to determine the best-fitted model.
Wawasan Teknologi dalam Pendidikan Jasmani, Ilmu Keolahragaan dan Kesehatan
Authors: Wijayanto Adi
Published: October 2023

Kehadiran buku ini dapat memberi pandangan mengenaipemanfaatan teknologi dalam dunia olahraga dan kesehatan,sehinga pendidikan jasmani, ilmu keohlaragaan dan Kesehatan dapat berlangsung dengan baik dan optimal dengan peran teknologi yang dapat digunakan. Selain itu, dalam buku ini juga memberikan gambaran tentang problematika dan dinamika olahraga dan kesehatan pada era teknologi.Buku ini terdiri dari tiga bab dengan yang pertamamembahas Teknologi dalam pembelajaran penjas sehingga pembelajaran penjas dapat berjalan dengan mudah dengan adanya dukungan teknologi. Kedua, peran teknologi dalam cabang olahraga. Dengan memuat materi tersebut hal ini sangat diperlukan dalam cabang olahraga untuk menunjang kinerja dari manusia dalam mengawasi pelaksanaan olahraga. Ketiga, Problematika dan dinamika olahraga dan Kesehatan pada era teknologi. Dalam pembahasan buku ini memberikan gambaran problematika dan dinamika dari dunia olahraga dan kesehatan pada era teknologi, serta pemecahan masalah pada era teknologidi dunia olahraga dan kesehatan
Yang Terdepan dalam Teknologi Pembelajaran
Authors: Wijayanto Adi
Published: October 2023

Kehadiran buku ini bertujuan untuk memberikanwawasan yang mendalam dan pemahaman yang komprehensif tentang peran teknologi dalam pembelajaran. Melalui berbagai topik yang disajikan dengan ringan dan mudah dipahami, buku ini diharapkan dapat memberikan manfaat bagi pembaca dari berbagai kalangan, termasuk pendidik, peserta didik, dan orangtua.
Pilar - pilar ekonomi islam
Authors: sari Intan permata
Published: October 2023

a) Hukum asal perbuatan adalah terikat dengan hukum syara Prinsip ini menyatakan bahwa setiap perbuatan memiliki hukum asal yang terikat dengan hukum syara' segala tindakan dianggap haram kecuali ada dalil yang memperbolehkannya.b) Hukum asal benda adalah mubah selama tidak ada dalil yang mengharamkan Prinsip ini menyatakan bahwa segala sesuatu di dunia ini dianggap mubah (boleh) kecuali ada dalil yang mengharamkannya. benda-benda dianggap halal kecuali ada dalil yang menyatakan sebaliknya.c) Apabila ada hukum syara' diterapkan maka akan ada kemashlahatan Prinsip ini menyatakan bahwa penerapan hukum syara' akan membawa manfaat dan kemashlahatan bagi individu dan masyarakat. Hukum syara' dianggap sebagai pedoman yang sempurna untuk menjalani kehidupa
Site selection of desert solar farms based on heterogeneous sand flux
Authors: Li Guoshuai , Tan Lihai , Yang Bao , Che Tao , Feng Guangcai , Ljungqvist Fredrik Charpentier , Luo Yayong , Du Heqiang , Zhao Hui , Zhang Ying , Huang Chunlin , Huang Ning , Tang Wenjun , Jin Rui , Li Xin
Published: October 2023

Site selection for building solar farms in deserts is crucial and must consider the dune threats associated with sand flux, such as sand burial and dust contamination. Understanding the changes in sand flux can optimize the site selection of desert solar farms. Here we use the ERA5-Land hourly wind data with 0.1°×0.1° resolution to calculate the yearly sand flux from 1950 to 2022. The mean of sand flux is used to score the suitability of global deserts for building solar farms. We find that the majority of global deserts have low flux potential (≤40 m3 m-1 yr-1) and resultant flux potential (≤2.0 m3 m-1 yr-1) over the past 73 years. The scoring result demonstrates presents that global deserts have obvious patch distribution of site suitability for building solar farms. Our study optimizes the site selection of desert solar farms, which aligns with the United Nations sustainability development goals for achieving affordable and clean energy target by 2030.
The influence of fluid inclusions, organics, and calcite fabric on trace element distributions in stalagmites
Authors: Stoll Heather , Kost Oliver
Published: October 2023

Growing stalagmites entrap water and organic molecules while incorporating trace elements in diverse crystallographic fabrics. However, the interrelationships between crystal defects, fluid inclusions, organic carbon incorporation, and trace element incorporation in stalagmites remain poorly constrained. Here we use for the first time Fourier Transformation Infrared Focal-Plane Array (FTIR-FPA) imaging to show the distribution of molecular water (3400 cm-1 absorbance) and organic matter (2983 cm-1) in calcite from recently grown stalagmites with known drip water hydrochemistry and one fossil stalagmite. To test if entrapped water in speleothem calcite affects the abundance or distribution of trace elements, the element distribution (Na, Mg, Sr, U, Al, Y and Zn) is mapped by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Transmitted Light (TL) Microscope imaging constrains crystal fabrics and displays visible features such as crystallites, crystal defects like fractures, pores or at small scale fluid inclusions, as well as detrital clays. We find that stalagmite areas with strong Organic Matter fluorescence (FOM) via Confocal Laser Scanning Microscopy (CLSM) coincide with areas of high FTIR absorbance at 2983 cm-1, suggesting common co-location of multiple organic matter types in the stalagmite. While microscopic fluid inclusions visible in transmitted light are also detected by FTIR 3400 cm-1 absorbance, the FTIR additionally detects in some samples abundant water in submicroscopic fluid inclusions detected by FTIR 3400 cm-1 absorbance, but not evident in transmitted light microscopy. In most samples, Na concentration is elevated in regions of high fluid inclusion density, suggesting that a significant portion of Na may be hosted in entrapped water rather than in the calcite, consistent with the very low partitioning coefficient of Na in calcite. Only samples forming under extremely rapid drips, with 100-fold higher Y than other samples, feature Na concentrations which appear dominated by coupled Y-Na substitution and little influenced by FI Na. Our analysis provides new evidence of the influence of fluid inclusions on trace element content of stalagmites and illustrates the utility of several non- destructive imaging techniques to improve interpretations of proxy signals based on trace elements.
The Influence of Demographic and Job-related Characteristics on Nurses’ Compassion Satisfaction and Fatigue
Authors: Shrestha Salina , Sharma Sunita , Gurung Santosh Kumar , Chapagain Ramkrishna , Dhungana Bharat Ram
Published: October 2023

Introduction: Growing stress and declining job satisfaction are the major challenges in nursing. Demographic and work-related factors may influence nurses’ compassion satisfaction and fatigue levels. Therefore, the study examined the impact of demographic and occupational factors on nurses’ professional quality of life.
Methods: A cross-sectional study was conducted on 172 nurses working in two tertiary care hospitals in Pokhara using proportionate stratified random sampling. Data was gathered using the Professional Quality of Life (ProQOL) scale version 5 in September 2019. SPSS was used for bivariate and multivariate analysis to determine a significant relationship between socio-demographic and work-related variables and three professional quality-of-life subscales. The ethical approval was taken from the Institutional Review Committee (IRC) of Pokhara University (Reference Number: 83-075-76).
Results: Most of the participants showed an average level of compassion satisfaction (79.1%, n=136), burnout (77.9%, n=134), and secondary traumatic stress (85.5%, n=147). The study revealed a significant mean difference between demographic characteristics (marital status and having children at home) and three professional quality of life subscales. Similarly, the study did not yield significant mean differences between the work-related variables and three professional quality-of-life subscales.
Conclusion: Nurses in tertiary care hospitals exhibited moderate to high levels of compassion satisfaction while experiencing moderate to low levels of burnout and secondary traumatic stress. Despite moderate to low levels of burnout and secondary traumatic stress, it is imperative to address these issues as they have the potential to lead to medical errors and compromise patient care standards.