bluuebunny/crossref_metadata_2025 huggingface dataset:
¿Un "imperio ibérico integrado"? El arbitrismo y el imperio ultramarino portugués (1580-1640)
Authors: Almeida Borges Graça
Published: October 2019

Este artículo trata sobre arbitristas y arbitrios centrados en el imperio ultramarino portugués durante el periodo de la incorporación de su imperio a la Monarquía Hispánica (1580-1640). El trabajo trata de dar solución a tres problemas: en primer lugar, pretende determinar quiénes eran estos arbitristas que escribían sobre el imperio ultramarino portugués y cuáles eran los objetivos de sus textos y escritos. En segundo lugar, intenta comprender, en la medida de lo posible, cómo se recibian esos documentos en los centros decisorios de la monarquía. En tercer lugar, examina hasta qué punto este conjunto de documentos reflejan la percepción de un "imperio ibérico integrado", en donde los territorios ultramarinos portugueses se presentaban plenamente incorporados a la política global de la monarquía.
Del infierno al edén. El viaje del marino Francisco Muñoz y San Clemente a la isla de Francia en 1787
Authors: Baudot Monroy María
Published: October 2019

En enero de 1786 zarparon de Cádiz los dos primeros barcos de la Compañía de Filipinas que inauguraron la nueva Carrera comercial directa entre la metrópoli y las Islas Filipinas por la ruta del Cabo de Buena Esperanza. Los barcos iban al mando del oficial de la Armada Francisco Muñoz y San Clemente. En el viaje de regreso el marino se vio obligado a resguardarse en Port Louis en la isla de Francia (Mauricio), que recorrió. Ya en Cádiz, escribió una sugerente relación de todo el viaje y de la expedición a la colonia francesa, rica en detalles científicos útiles para posteriores navegaciones y en reflexiones políticas y comerciales sobre la economía filipina para el funcionamiento de la Compañía.
Classification-Based Inference of Dynamical Models of Gene Regulatory Networks
Authors: Fehr David A , Handzlik Joanna E , Manu  , Loh Yen Lee
Published: October 2019

Cell-fate decisions during development are controlled by densely interconnected gene regulatory networks (GRNs) consisting of many genes. Inferring and predictively modeling these GRNs is crucial for understanding development and other physiological processes. Gene circuits, coupled differential equations that represent gene product synthesis with a switch-like function, provide a biologically realistic framework for modeling the time evolution of gene expression. However, their use has been limited to smaller networks due to the computational expense of inferring model parameters from gene expression data using global non-linear optimization. Here we show that the switch-like nature of gene regulation can be exploited to break the gene circuit inference problem into two simpler optimization problems that are amenable to computationally efficient supervised learning techniques. We present FIGR (Fast Inference of Gene Regulation), a novel classification-based inference approach to determining gene circuit parameters. We demonstrate FIGR’s effectiveness on synthetic data generated from random gene circuits of up to 50 genes as well as experimental data from the gap gene system of Drosophila melanogaster, a benchmark for inferring dynamical GRN models. FIGR is faster than global non-linear optimization by a factor of 600 and its computational complexity scales much better with GRN size. On a practical level, FIGR can accurately infer the biologically realistic gap gene network in under a minute on desktop-class hardware instead of requiring hours of parallel computing. We anticipate that FIGR would enable the inference of much larger biologically realistic GRNs than was possible before.
Historical Introgressions from a Wild Relative of Modern Cassava Improved Important Traits and May Be Under Balancing Selection
Authors: Wolfe Marnin D , Bauchet Guillaume J , Chan Ariel W , Lozano Roberto , Ramu Punna , Egesi Chiedozie , Kawuki Robert , Kulakow Peter , Rabbi Ismail , Jannink Jean-Luc
Published: October 2019

Introgression of alleles from wild relatives has often been adaptive in plant breeding. However, the significance of historical hybridization events in modern breeding is often not clear. Cassava (Manihot esculenta) is among the most important staple foods in the world, sustaining hundreds of millions of people in the tropics, especially in sub-Saharan Africa. Widespread genotyping makes cassava a model for clonally propagated root and tuber crops in the developing world, and provides an opportunity to study the modern benefits and consequences of historical introgression. We detected large introgressed Manihot glaziovii genome-segments in a collection of 2742 modern cassava landraces and elite germplasm, the legacy of a 1930s era breeding to combat disease epidemics. African landraces and improved varieties were, on average, 3.8% (max 13.6%) introgressed. Introgressions accounted for a significant (mean 20%, max 56%) portion of the heritability of tested traits. M. glaziovii alleles on the distal 10 Mb of chr. 1 increased dry matter and root number. On chr. 4, introgressions in a 20 Mb region improved harvest index and brown streak disease tolerance. We observed the introgression frequency on chr. 1 double over three cycles of selection, and that later stage trials selectively excluded homozygotes from consideration as varieties. This indicates a heterozygous advantage of introgressions. However, we also found that maintaining large recombination-suppressed introgressions in the heterozygous state allowed the accumulation of deleterious mutations. We conclude that targeted recombination of introgressions would increase the efficiency of cassava breeding by allowing simultaneous fixation of beneficial alleles and purging of genetic load.
Physicochemical Parameters of Magmatism of the Uksichan and Ichinsky Volcanoes (Sredinnyi Ridge, Kamchatka): Data on Melt Inclusions
Authors: Dobretsov N.L. , Simonov V.A. , Kotlyarov A.V. , Karmanov N.S.
Published: October 2019

—Thermobarogeochemical study of melt inclusions and investigation of clinopyroxenes and amphiboles from effusive rocks of the Uksichan and Ichinsky Volcanoes gave an insight into the parameters of deep-seated melts and the evolution of magmatic systems during the formation of minerals in intermediate chambers. Study of melt inclusions from the Uksichan volcanic rocks made it possible to estimate the pressure during the liquidus crystallization of clinopyroxenes and plagioclases from basaltic magmas and to establish four depth intervals of the formation of these minerals: ~60, 45–30, 27–18, and from 12 km to the subsurface. Comparison of the results of calculation based on melt inclusion data and of the clinopyroxene and amphibole data helped to establish the evolution paths of the P–T parameters of ascending melts of the Uksichan Volcano. The most high-temperature magmas, generated at a depth of ~60 km, are characterized by a successive temperature decrease during their ascent (1320–1240–1200 °С). Based on the representative data on the compositions of amphiboles from the Uksichan and Ichinsky Volcanoes, we have elucidated the general regularities of the evolution of intermediate and acid magmatic systems, with three depths of crystallization in intermediate chambers. Amphiboles of the Ichinsky Volcano andesites and the Uksichan Volcano latites crystallized at depths of 22.0–18.5 and 18–16 km and at temperatures of 980–930 and 1010–985 °С, respectively. As melt ascended to a depth of 15.5–11.0 km and a temperature decreased from 945 to 880 °С, amphiboles of andesites and dacites of both volcanoes were produced. At the final stage (a temperature decrease to 900–810 °С and ascent of melts to a depth of 3 km), only amphiboles of dacites of both volcanoes crystallized.
A ajuda na saúde como práxis política num município do Estado do Rio de Janeiro: uma abordagem etnográfica
Authors: Gomes da Silva Sarmento Gilmara
Published: October 2019

Neste artigo, pretendo abordar, de uma perspectiva etnográfica, as lógicas morais que produziram a ajuda na saúde como práxis política num município do estado do Rio de Janeiro, Brasil. A análise evidenciou que a emergência dessa prática antecedeu à criação do município e seguiu reproduzindo-se após a emancipação municipal. A manutenção desse status quo resulta da confluência entre distintas variáveis e se reproduz num contexto em que elementos de obrigação moral, produzidos por vínculos emocionais e afetivos, se articulam ao uso intencionado da ajuda. Entre a obrigação e o interesse, a ajuda na saúde acaba se constituindo num recurso social importante na produção de políticos e na legitimação de carreiras.
Domestic work = language work? Language and gender ideologies in the marketing of multilingual domestic workers in London
Authors: Vessey Rachelle
Published: October 2019

The hiring of domestic workers – normally female – in the globalised economy involves assumptions and expectations not only about the so-called ‘natural’ female instinct for childcare and cleaning, but also about language use and transmission. Domestic worker agencies play an important role at the interface between the public sphere (where the languages are normally valuable) and the home (the workplace of domestic workers). An examination of the skills discourses used in the marketing of domestic workers reveals tensions between the language and gender ideologies underpinning this juncture. Using corpus linguistics to examine London-based domestic worker agency websites, findings reveal highly traditional and conservative notions of language and gender underpinning contradictory arguments about the supposedly advantageous nature of multilingualism.
Feeling Academic in the Neoliberal University: Feminist Flights, Fights and Failures edited by Yvette Taylor and Kinneret Lahad (2018)
Authors: Paterson Laura L.
Published: October 2019

Feeling Academic in the Neoliberal University: Feminist Flights, Fights and Failures edited by Yvette Taylor and Kinneret Lahad (2018) Basingstoke: Palgrave Macmillan, 368pp.
CIC Mutation as a Molecular Mechanism of Acquired Resistance to Combined BRAF-MEK Inhibition in Extramedullary Multiple Myeloma with Central Nervous System Involvement
Authors: Da Vià Matteo Claudio , Solimando Antonio Giovanni , Garitano-Trojaola Andoni , Barrio Santiago , Munawar Umair , Strifler Susanne , Haertle Larissa , Rhodes Nadine , Teufel Eva , Vogt Cornelia , Lapa Constantin , Beilhack Andreas , Rasche Leo , Einsele Hermann , Kortüm K. Martin
Published: October 2019

Combined MEK-BRAF inhibition is a well-established treatment strategy in BRAF-mutated cancer, most prominently in malignant melanoma with durable responses being achieved through this targeted therapy. However, a subset of patients face primary unresponsiveness despite presence of the activating mutation at position V600E, and others acquire resistance under treatment. Underlying resistance mechanisms are largely unknown, and diagnostic tests to predict tumor response to BRAF-MEK inhibitor treatment are unavailable.

Multiple myeloma represents the second most common hematologic malignancy, and point mutations in BRAF are detectable in about 10% of patients. Targeted inhibition has been successfully applied, with mixed responses observed in a substantial subset of patients mirroring the widespread spatial heterogeneity in this genomically complex disease. Central nervous system (CNS) involvement is an extremely rare, extramedullary form of multiple myeloma that can be diagnosed in less than 1% of patients. It is considered an ultimate high-risk feature, associated with unfavorable cytogenetics, and, even with intense treatment applied, survival is short, reaching less than 12 months in most cases. Here we not only describe the first patient with an extramedullary CNS relapse responding to targeted dabrafenib and trametinib treatment, we furthermore provide evidence that a point mutation within the capicua transcriptional repressor (CIC) gene mediated the acquired resistance in this patient.

Key Points

BRAF mutations constitute an attractive druggable target in multiple myeloma. This is the first genomic dissection of the central nervous system involvement in a multiple myeloma patient harboring a druggable BRAFV600E mutation. Deep genomic characterization of the extramedullary lesion prompted a personalized therapeutic approach. Acquisition of CIC mutation confers a mechanism of BRAF-MEK inhibitor drug resistance in multiple myeloma. The in silico interrogation of the CoMMpass clinical study revealed 10 patients with somatic mutations of CIC and its downregulation at gene expression level in multiple myeloma. CIC gene silencing decreases the sensitivity of multiple myeloma cells to BRAF-MEK inhibition in vitro. The correlation between CIC downregulation and ETV4/5 nuclear factor expression in multiple myeloma BRAF-mutant cells is shown for the first time. CIC mutation, its downregulation, and the related downstream effect on MMP24 support disseminative potential providing new clues in the extramedullary biology definition.
Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia
Authors: Kreitman Robert J. , Pastan Ira
Published: October 2019

Hairy cell leukemia (HCL) is an indolent B-cell malignancy characterized by high initial sensitivity to purine analog chemotherapy, minimal residual disease (MRD) frequently accompanying complete remission (CR), and relapses requiring additional treatment. Repeat chemotherapy shows decreasing efficacy and increasing toxicity with each course. Newer therapies targeting BRAF/MEK or Bruton's tyrosine kinase are effective but generally leave MRD. Rituximab has modest activity as a single agent and can achieve MRD-negative CR in combination with purine analogs, but there is significant toxicity from the chemotherapy. Moxetumomab pasudotox-tdfk (Moxe) is a biologic containing an antibody fragment (Fv) binding to CD22, attached to a portion of Pseudomonas exotoxin A. Binding to CD22 enables the toxin to enter and kill cells. Moxe is administered by 30-minute infusions on days 1, 3, and 5 of up to six cycles spaced 4 weeks apart. In phase I testing, 64% of 33 patients at the highest dose level achieved CR, most without MRD. Lack of MRD correlated with prolonged CR duration; of 11 MRD-negative CRs, 10 were still in CR after a median of 42 months of observation. In pivotal testing, 75% of 80 patients had a hematologic response, 41% with CR; 82% (27/33) of CRs were MRD-negative, and only 4 of the 27 MRD-negative patients relapsed during the follow-up period. Hemolytic uremic syndrome and capillary leak syndrome were each observed in 9% of patients, all reversible. In September 2018, the U.S. Food and Drug Administration approved Moxe for the treatment of relapsed/refractory HCL after ≥2 prior therapies. Moxe is undergoing further development in combination with rituximab.
Assessing the impact of infrastructure projects on global sustainable development goals
Authors: Mansell Paul , Philbin Simon P , Broyd Tim , Nicholson Ian
Published: October 2019

While the sustainability of civil infrastructure is critical to professionals, project owners, regulators, funding agencies and the public, little is done to link individual project sustainability to the UN’s 17 global sustainable development goals for 2030. This paper not only provides some answers, but also exposes many questions that need resolution by the infrastructure sector. Using empirical evidence, the authors have identified a ‘golden thread’ between best-practice sustainability-reporting frameworks at the project level and those at the organisational level. In doing so, they have found that there is sufficient linkage to embed sustainable-development-goal impact targets into the design stage of an infrastructure project. This would provide a more robust investment appraisal at the project design phase, helping define project success more widely across the triple bottom line of economic, social and environmental outcomes and associated impact.
Approaches to Estimating Aggregate Demand for Reserve Balances
Authors: Andros Joseph , Beall Michael , Martinez Francis , Rodrigues Tony , Styczynski Mary-Frances , Thorp Alex
Published: October 2019

This note describes our approach in estimating aggregate reserve demand using survey-reported data and two methods to account for sampling and non-sampling error, concluding with a discussion of some important items for consideration.
Foreign Portfolio Investment When the United States was an Emerging Market
Authors: Weiss Colin , Monge Julio
Published: October 2019

In this note, we analyze two surveys occurring in 1853 and 1869 and compare the patterns of foreign ownership then to foreign portfolio investment in the present-day United States.
Modeling of TV News in the Context of Information Policy of a Television Channel
Authors: Sumskaya Anna , Sumskoy Pavel
Published: October 2019

TV viewers build relationships with the outside world, focusing on the news, which is a television interpretation of reality. Media reality is created on the basis of the information policy of TV channels and determines the agenda of the audience. This paper uses M. McCombs' agenda-setting theory, N. Luhmann's cognitive system communication, W. Lippmann's public opinion concept, J. Baudrillard's simulacrum, J. Fiske's code structure, G. Deborah's Performance Society to study television news of Russian TV channels. Based on the systemic, structural-functional, and semiotic approaches, the application of models of communication, information, the cognitive model of the impact of the media on the mass audience and the model of Russian journalism, a TV news projection model was developed in the context of a television channel's information policy. The model was tested on the basis of analysis of 130 news stories of the final weekly news releases of two federal and two regional Russian TV channels. As a result, we have seen that the media reality is constructed as a result of a selection of facts, modeling of meanings and forms of submission of news. The differences in the themes and forms of the news delivery are due to the territorial affiliation and technological development of the channels. In the production process, the journalist acts as an informer, communicator and manipulator, and the news represent a socially constructed and thoroughly edited reality. The media create a similar media reality, a different level of fiction, intended, albeit for the post-Soviet, but still society of centralized spectacle (according to G. Deborah). Translated meanings correspond to the symbolically-oriented mentality of Russians (according to M. Zagidullina). The media reality formed by the TV channels proves that the domestic journalists follow the special Russian way.
Media Criticism: Between Theory and Practice
Authors: Vladimirova Tatiana , Slavina Valentina
Published: October 2019

The article raises the problems of modern journalism, denotes such concepts as mass communication, media, media criticism. In the authors' opinion, media criticism is an invitation to the reader to a discussion, an open conversation, an appeal to pressing socio-political problems, publication of an alternative opinion that is necessary for any free society. Media criticism acts as a science, where both analysis, synthesis and forecast are present. The social importance of media criticism is underlined. It is noted that mass media criticism is no less important than professional media criticism. According to the authors, non-professionals in journalism can act from critical positions and are quite professional in relation to the media, for example, sociologists, economists, politicians. The authors analyze the current state of critical analytics in various media and communication. In detail, the research is undertaken with respect to the journal «Journalist» and «Novaya Gazeta», which present various aspects of media analysis. The authors tried to find out what has changed in journalism over the past few years? What is the status of journalistic criticism today? On the basis of the analysis, conclusions were drawn that the publications in «Novaya Gazeta» can be attributed to professional criticism, since the authors themselves are a representative of the journalistic profession. On the other hand, the media criticism of «Novaya Gazeta» can be called mass, since it is addressed to civil society. An example of professional criticism is, with full justification, the publications of the journal «Journalist», since academic criticism presupposes a scientific analysis based on theoretical comprehension, the ability to correlate social problems with their reflection in media products.
Printed Publications of Irkutsk Military School as a History of Military Cadres Training in Eastern Siberia
Authors: Astrakhantsev Oleg , Petrushin Yury
Published: October 2019

Irkutsk (Cadet) Military School was founded in 1874 in Irkutsk. The School began training military officers for military bases located not only in Siberia, but all over Russia. Since its foundation the School has trained dozens of thousands of highly-qualified specialists for the army. The School has been through difficult times over the course of its development. Opened as a cadet school first it soon received a higher status becoming a military school. It functioned as a military school until the Civil War when it was disestablished. In 1931 the school was reestablished, however, as an aviation technical school and existed in this status while undergoing several reorganizations until 2009. Since the schools foundation it has had a number of printed publications covering its life and activities. These publications are usually not available for the majority of researchers as they were circulating only among military men and the schools faculty members and were not issued for mass circulation. Being an officer of Irkutsk Military School O. N. Astrakhantsev managed to collect some of the schools printed publications. Having analyzed these publications and relying on the principles of historism, the social approach and the comparative historical method the authors of the article conclude that nowadays these publications are a valuable source for studying the military schools history. The analysis of these publications allows one to take a fresh look at this military school everyday life. The comparison of these publications with archive documents and statutory acts and some other documents allows one to reconstruct in more detail and evaluate more precisely the schools activities at a particular time. The article describes evolution of printed publications, studies their main trends and peculiarities.
Aggressivness and Autoagressivness in the Web Text: Content Analysis of Pages in the Social Network «VKontakte»
Authors: Malahaeva Svetlana , Potapov Roman
Published: October 2019

The authors make a supposition that any social network is an array of texts that can be formally analyzed. Relying on the ideas of cultural-historical psychology, the authors consider the text as a model that is used to cognize the world and with the help of which higher mental functions are formed. The network text is analyzed as a semiotic system. The authors have created categories of the content analysis of pages in the social network VKontakte. These categories help to assess a persons aggressiveness and auto-aggressiveness. The respondents were 58 women and 63 men aged from 17 to 23. Complex research into aggressiveness and auto-aggressiveness, and deviant behavior was carried out using V.V. Boikos and A.N. Orels methodologies. The data of the content analysis and the data of both tests were statistically processed. The analysis using Pearsons correlation coefficient demonstrated many interconnections between the presence and the extent of the content analysis categories and the data from the standardized methodologies. A strong direct correlation relationship between the auto-aggressiveness index by V.V. Boikos methodology and reasons for violence (0,72), depression (0,92), auto-aggression (0,63) and isolation (0,63) are similar with the data received applying the self-harming scale methodology by A.N. Orel: there is a strong direct correlation with violence (0,72), depression (0,93), auto-aggression (0,64) and isolation (0,68). The authors found a strong direct correlation between motives for violence and the tendency for aggression and violence index in accordance with A.N. Orels methodology (0,72). By A.N. Orels methodology he authors found a strong direct correlation between the motive for accepting criminal norms and the tendency for delinquent behavior (0,79). A correlation relationship between the motive for eroticism and inability for restraining aggression (0,62) was also revealed. The authors have interpreted correlation relationships. The factor analysis by the Kaiser criterion demonstrated that there are five logically interconnected factors. The research hypothesis has been proved. Prospects for follow-up research have been outlined.
Restoration of euglycemia in the RCS10 mice with Metformin v2
Authors: Simpson Ian
Published: October 2019

Summary: In this series of studies we wished to determine whether Metformin was able to establish and maintain euglycemia in RCS10 mice and would reduce infarct volume following a stroke. Metformin is a widely prescribed agent to treat Type II diabetes and as illustrated in Figure 2, when Metformin (0.8-1.3 g/kg/D) is included in the water, it is able to establish and maintain euglycemia in the RCS10 mice over a 4- week period. However, as illustrated in in Figure 3, restoration of euglycemia with metformin did not improve ischemic outcome. Diabetic Complications:
Frequently sampled Insulin glucose tolerance test v2
Authors: Nichols Timothy , Clemmons David
Published: October 2019

Summary: This assay is used by the DiaComp to measure glucose tolerance and insulin sensitivity in pigs. Diabetic Complications: Reference: 1. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 1985, 6:45-86.
Vascular perfusion of mice v2
Authors: Mundel Peter
Published: October 2019

Summary: This protocol describes the procedure for perfusion of mice prior to organ or tissue harvesting . Diabetic Complications:
Breeding Scheme and Selection of Animals for DiaComp Experiments v2
Authors: Maeda Nobuyo , Smithies Oliver , Takahashi Nobuyuki
Published: October 2019

Summary It is extremely important to measure quantitative parameters (e.g. plasma glucose, urinary albumin, etc.) in a way that minimizes the effects of any adventitious variables, such as seasonal changes, dietary differences, any differences in the degrees of backcrossing, or unplanned differences in genotypes. This means that, whenever possible, mice of the critical genotypes should be obtained from genotypically identical matings carried out at or close to the same time. Archival data are not appropriate. The breeding scheme to generate the experimental animals can vary in complexity, depending on the fertility of the two genders, whether the Testgene is to be studied in homozygotes or in heterozygotes, and whether the diabetes is induced genetically or by STZ. However, it is important to remember that, when looking for the effects of the Testgene genotype on diabetic complications, the aim is to compare the Testgene mutant/mutant (or Testgene mutant/wt) diabetic animals with their diabetic litter mates that are wildtype at the Testgene locus (Testgene wt/wt). Reference Wang, C-H, Li, F, Hiller, S, Kim, H-S, Maeda, N, Smithies, O, and Takahashi, N. A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc. Natl. Acad. Sci. USA 108(5): 2070-2075 (2011) PMID: 21245338 PMCID: PMC3033253. Diabetic Complications:
The Relationship of Youth Family Values with Hedonism and Eudemonia
Authors: Anoshkin I. V. , Sychev O. A.
Published: October 2019

Introduction. A notable trend in modern society is the transformation of family institution, which has long been considered the most important social and personal value. The change of attitudes of young people towards marriage in Russia is slower than in Europe; however, this process is becoming more obvious today and there is an urgent need to study it. So far, very little research has been carried out. In psychology and other social sciences, it is widely believed that the family formation is hampered by a hedonistic worldview. However, it is well known that the family provides the opportunities to meet many important human needs. This contradiction has prompted the direction of the present research.

Theaimof this research is to empirically investigate whether there is the conflict of the perceptions of the Russian young people about family values and hedonic and eudemonic orientations.

Methodology and research methods.The empirical research was conducted using K. Peterson’s questionnaire “Happiness Orientations”. 173 students (49% female) took part in the research project. To assess the importance of family and different family values, the authors of the present research elaborated a special questionnaire, the reliability of which was confirmed in the course of approbation. The information obtained was processed through the means of correlation, regression analysis and nonparametric statistics in Statistica 10; confirmatory factor analysis of questionnaires was performed in Mplus 7.

Results.The results of path analysis of interrelations between hedonism, eudemonia and family values indicated that family values were correlated not only with the orientation to meaningful and dignified life (eudemonia), but also with the orientation to pleasure (hedonism). The orientation hedonism was higher in young women; therefore, multiple regression analysis of the relationship between the studied phenomena was conducted in separate male and female groups of respondents. The results demonstrated that the value of birth and child-rearing in women is correlated with hedonism; the general value of family in male respondents is related with eudemonia.

Scientific novelty.This investigation confirms that there is no contradiction between hedonism and family values. The research findings deduce that both eudemonic and hedonic orientations support family values, although the system of relationships between these orientations may vary according to gender. This finding expands our knowledge about hedonism and its role in modern society.

Practical significance.The research results expand the understanding of hedonism and its role in modern society, clarifying the content of activities to prepare young people for family life. In order to enhance the effectiveness of such psychological and pedagogical support, one should take into account the hedonic tendencies of young people, revealing the importance of family formation in the context of personal happiness.
Composition and characterization of substantive statements of strategic planning tasks: analysis of changes in the conditions of the formation of a digital management platform
Authors: Pisareva O. M.
Published: October 2019

The article discusses the impact of the formation of a digital platform in the public administration system on the nature of the management tasks of strategic planning. The mainaspects of the assessment of changes in the spectrum and content of strategic planning tasks due to the digitalization of management technologies are formulated. The composition of the tasks of strategic planning is described taking into account the state of the current institutional base. The possibilities of using formalized methods for solving them within the framework of a digital platform for supporting public administration are identified.

Purpose: the formation of the information society is associated with the development and implementation of a wide range of end-to-end digital technologies in various areas of public life and business. Modernization of information technology along with a general change in the conditions for the development of socio-economic systems determines the corresponding changes in methods and mechanisms of public administration. In this regard, the main goal of the work is to study aspects of the impact of digital transformation on the composition and characteristics of strategic planning tasks.

Methods: the study was carried out based on a systematic approach to the study of socio-economic systems and processes using the methods of logical and comparative analysis, methods of statistical analysis of indicators of the functioning of the strategic planning system in the Russian Federation, providing the necessary depth of consideration of scientific problems.

Results: the author presented an analysis of scientific and practical publications on the research topic, as well as the composition, functional and substantive capabilities of an automated information system for supporting strategic planning. The results of data processing of official statistical and management reporting in the field of development and implementation of strategic planning documents are presented. This made it possible to determine approaches to assessing the composition and characteristics of strategic planning tasks in the context of the formation of a digital public administration platform, to propose a compositional scheme for describing the relationship between the composition and content of planning tasks with a system of strategic planning documents.

Conclusions and Relevance: the materials presented in the article make it possible to identify the current problems of implementing the strategic management methodology into the regulatory practice of public administration bodies, to substantiate the directions for improving the methodology and strategic planning tools, including through the correction of specifications and formalization of planning tasks in the context of the formation of a digital public administration platform.
Analysis of Factors Affecting Millennial consumers’ Demand for halal Bread Products
Authors: Oktavia Ludiah , Marwa Taufiq , Yulianita Anna
Published: October 2019

Purpose: this study aimed to examine the factors affecting millennial consumers’ demand for halal labeled bakery products (sweet bread).

Methods: this research used a quantitative approach to estimate the dominant factors affecting Muslims’ demand, based on multiple regression analysis using the Ordinary Least Square (OLS) method.

Results: (1) The prices and income had a positive and significant effect on millennial consumers’ for halal-labeled bakery products. (2) The halal issue had a positive but insignificant effect on millennial consumers’ demand for halal-labeled bakery products. (3) millennial consumers’ demand for halal-labeled bakery products did not vary depending on taste and method of payment.

Conclusions and Relevance: the price was a determinant factor in the demand for halal bakery products. So we recommend that millennial consumers should consider both bread price and quality and whether it is halal or not. The halal concern had actually a positive but insignificant effect, because millennial generation students are expected to pay more attention to the halal issue by considering halal labeling and composition of bakery products (sweet bread) and by having knowledge of halal products.
El origen del valor presente como un criterio para la decisión de presupuesto de capital: un viaje a Pisa en la Edad Media
Authors: Avellaneda Mauricio
Published: October 2019

El surgimiento de nuevas técnicas para la evaluación de inversiones, como las opciones reales, no ha logrado desplazar al valor presente neto como una de las metodologías más utilizadas para evaluar la viabilidad de una inversión. Este artículo busca explorar los orígenes del valor presente neto como una técnica para la evaluación entre alternativas de inversión. William Goetzmann sitúa el origen de esta metodología en la Edad Media, específicamente en las primeras décadas del siglo xiii, en Liber abbaci, la obra maestra de Leonardo de Pisano, más conocido como Fibonacci. Lo anterior reevalúa la creencia que sitúa este concepto en los trabajos de Irving Fisher de 1930. En cuanto al origen del sobrenombre de Fibonacci, esta investigación encontró que Pietro Cossali utilizó y explicó su significado en un escrito de 1799. Lo anterior permite reevaluar la creencia de que el apodo de Fibonacci fue dado por Guillaume Libri en 1838. Por último, este documento ofrece un tributo a todos aquellos investigadores, en este caso de la historia de las matemáticas, que como consecuencia de su trabajo arqueológico redescubren avances y desarrollos que de otra forma serían olvidados.
Análisis de influencia de la red de colaboración de opciones reales
Authors: Coutinho Fagundes Hernandes , Tavares Nogueira Rodrigo
Published: October 2019

La teoría de opciones reales surgió como una alternativa para valorar las flexibilidades arraigadas en proyectos y ha adquirido popularidad desde finales del siglo xx. A través de métodos bibliométricos y teoría de grafos, este documento crea un análisis de la red de colaboración compuesta por los investigadores de opciones reales, que incluye trabajos científicos de dieciocho años. En este esfuerzo identificamos meticulosamente a los autores y sus alianzas de coautoría, encontrando una topología distinta sin un componente gigante. Al desarrollar modelos no ponderados y ponderados, la red se desenreda y proporciona mediciones a partir de la propensión a la internacionalización y el cálculo de diferentes métricas de impacto, que reconocen a los investigadores más relevantes sobre el tema.
HYGIENIC EVALUATION OF THE EFFECT OF ELECTROMAGNETIC FACTORS OF COMMUNICATION DEVICES ON THE STATE OF STUDENT’S HEALTH
Authors: Yashchenko Svetlana G. , Rybalko S. Yu. , Pilunskay O. A. , Shibanov S. E.
Published: October 2019

During the study at the University, the amount of information received by students is significantly increased. This causes the wide use of modern communication devices (personal computers, tablets, mobile phones). A feature of their using is the finding of a person in the immediate vicinity of a source of electromagnetic radiation. In the work, there was made an assessment of the intensity of the use of communication devices by students from 2000 to 2014. The students surveyed had an increase in electromagnetic load from personal computers (PC) by 2.83 times, mobile phones (MР) - by 20.34 times. During the same period, the health state of students was monitored. The level and nature of diseases, the features of nutrition, lifestyle were assessed. The incidence of respiratory diseases, diseases of the nervous system and sensory organs appeared to be the highest. Neoplasms, endocrine pathology, blood and hemopoietic diseases and a number of other diseases are few, heterogeneous and have a beginning most often before admission to the university. For the period of observation, the number of students who never fell ill during the whole period of training decreased by 32.67% against the background of a study of the nature of nutrition, motor activity, the prevalence of bad habits and self-esteem of their health status. During the correlation analysis, reliable positive connections were established between the prevalence rate of eye diseases and the individual dose-bearing electromagnetic load (IDEL) of MP and PC. There was established the negative relationship between MP IDEL and the prevalence rate of ear diseases, positive relationship was found between PC IDEL and prevalence rate of respiratory diseases.
THE ROLE OF SPECIFICITY AND NOT SPECIFICITY OF THE INFLUENCE OF LOCAL FACTORS OF THE HABITAT IN FORMATION OF MASS NONINFECTIOUS DISEASES
Authors: Prusakov V. M. , Prusakova Aleksandra V.
Published: October 2019

Detection of nonspecific and specific answers in population on action of a complex of local factors in the form of mass noninfectious diseases (MNID) is urgent for their further monitoring, the development of preventive actions when taking into account a role of adaptation reactions and adverse local factors of the habitat in their formation, the introduction and control of an efficiency of actions for the decrease in the MNID prevalence rate, the improvement of indices of the habitat and quality of life of the population. The aim of the study was to substantiate the main indices of the specificity of non-infectious disease (NID) complexes of the children’s population under the influence of local environmental factors. The mechanism of the formation of wavy dynamics of risk of incidence of noninfectious diseases and waviness of the corresponding adaptation process is analyzed. Simplified models of wavy processes of the formation of risk of the incidence rate and intensity of corresponding adaptation processes with the determination of their parameters are presented. 3 groups of indices for the detection of the specific response of the children’s contingents to the action of local factors of certain territories are considered: 1) indices of the characteristic of a form of wavy dynamics; 2) key parameters of wavy dynamics and 3) prevalence rates of classes of separate diseases in the each territory are presented by: a) number and a list of classes of MNID with a different level of a risk of the incidence in children and b) the leading classes of MNID. There are proposed both classification criteria for separate classes of MNID and the assessment of the adaptation process and the level of exposure to local environmental factors on the level of their disease risk. The integrated characteristic of the specificity and expressiveness of impact of local factors of the habitat on the children’s population is established to be complexes of MNID classes and the number of diseases among them with the “very high”, “high” and “elevated” risk of the incidence. The specificity of the MNID complexes in each territory is formed by the structure and number of classes MNID, risk level of their incidence.
BACTERIA AND PARASITIC PATHOGENS IN CONDITIONS OF CHEMICAL POLLUTION OF WATER FROM SURFACE WATER BODIES
Authors: Rakhmanin Yury A. , Ivanova L. V. , Artemova T. Z. , Zagaynova A. V. , Gipp E. K. , Nedachin A. E. , Maksimkina T. N. , Kuznetsova K. Yu. , Aslanova M. M. , Novozhilov K. A. , Gritsyuk O. V. , Malysheva A. G. , Abramov E. G. , Kamenetsky D. B. , Vodianova M. A.
Published: October 2019

There were identified priority pollutants in water of the Moscow river below the city (petroleum products, lead, cadmium, zinc, copper; anionic surfactants), which can affect the natural microbiocenosis of surface water. The presence in surface waters heavy metals - cadmium in a concentration of 4 MPC for fishery purposes, of lead at a concentration of 5 MPC for fishery purposes, oil at a concentration of 49 MPC, zinc at a concentration of 10 MPC for fishery purposes, anionic surfactants at the concentrations below the MPC, and also at excess of MPC by 5 times for chlorides, nitrites and nitrates to a large extent was established to affect the viability of indicator bacteria - coliforms, E. coli, enterococci, while maintaining in the water of pathogenic bacteria - Salmonella and parasitic pathogens living Entamoebae spp. and cystic viable vegetative forms of pathogenic protozoa Flagellata spp. and viable helminth eggs Larvae spp.
POPULATION HEALTH OF CHILDREN, RISKS TO HEALTH AND SANITARY AND EPIDEMIOLOGICAL WELLBEING OF STUDENTS: PROBLEMS, WAYS OF SOLUTION AND TECHNOLOGY OF THE ACTIVITY
Authors: Kuchma V. R. , Sukhareva L. M. , Rapoport Irina K. , Shubochkina E. I. , Skoblina N. A. , Milushkina O. Yu.
Published: October 2019

Results of the analytical development of data of the official statistical reporting on morbidity on negotiability of children and teenagers of the city of Moscow during 2005-2013 have shown the preservation of steady negative trends in the rise of the general morbidity, incidences of respiratory and school-related diseases, including diseases of musculoskeletal system, myopia etc. According to the longitudinal study of the state of health and physical development of the Moscow school pupils from 1 to 11 classes (2005-2015) the gain of the prevalence rate of functional disorders and chronic diseases in the course of school ontogenesis has been shown. The leading violations of students’ health with a tendency to increase in the prevalence rate are: functional violations of the musculoskeletal system, blood circulatory system, organ of vision, neuro-psychiatric disorders, as well as chronic diseases of musculoskeletal system, digestive and vision organs. In all age and sex groups of schoolchildren there is a reliable increase in body length and weight, chest circumference, acceleration of biological maturation in comparison with peers of the last decades. Indices of the muscular force of the right hand in modern schoolchildren have decreased in comparison with the supervision of 1960s and 1980s. The necessary condition of health preservation of children and teenagers is the providing safe and optimum conditions of education, training and life activity. The assessment of the efficiency of sanitary and epidemiological surveillance of training conditions of children and teenagers has shown an insufficient informational content of the assessment of a sanitary state of educational organizations on groups of sanitary and epidemiologic wellbeing (SEW). Institutions with the reduced SEW level (2 groups) were proved to have a significantly higher risk of formation of diseases, including school caused diseases. It has been developed a modern classification of the assessment of conditions and modes of training of children at the school characterizing the risk degree to health of students of training conditions (optimum, admissible, potentially dangerous and dangerous). In addition new standard and methodical documents on carrying out sanitary-epidemiological expertise for the provision of sanitary and epidemiological welfare of students in secondary schools have been developed and proved.
MODERN APPROACHES TO THE ASSESSMENT OF PESTICIDE MUTAGENICITY
Authors: Rakitsky V. N. , Ilyushina N. A. , Revazova Yu. A.
Published: October 2019

Research on potential mutagenic pesticide activity is an important part of their toxicological and hygienic assessment. The present article provides international and Russian legal and normative documents, which regulate such investigations. There is presented a list of the principal Organization for Economic Cooperation and Development (OECD) protocols in the field of genetic toxicology which reflect protocols in force, newly adopted and canceled protocols along with the revised versions of existing documents. As an example, major changes of the research protocol for mutagenic properties of chemical compounds in mammalian erythrocyte micronucleus test in vivo are reviewed. The article also provides the minimal set of methods required for the evaluation of the pesticide-induced initial DNA damage, gene, chromosome and/or genome mutations. The article notes the need for the mutagenic assessment of generic pesticides to verify the equivalence of active ingredients and carry out further studies of the combined actions of pesticide mixtures/