bluuebunny/crossref_metadata_2025 huggingface dataset:
The Origin and Characteristics of Islamic Community-Based Enterprise: An Exploratory Case Study in Bandung City
Authors: Alamsyah Indra Fajar , Omar Azura
Published: September 2023

Prior research has investigated the role of Islamic values in community-based enterprise. The authors contributed to this line of research by exploring a community-based perspective. Using the resource-based view theory fundamental lens, this study aims to reveal the origins and unique characteristics of Islamic community-based enterprise. This research is an exploratory research with qualitative case study research involving 9 participants, all of whom are founders of a community-based business that uses Islamic principles. This study uses in-depth interview and observation as methods. The results show there are 3 origins of Islamic community-based enterprises, all of which have differences with conventional community-based enterprises. As for the characteristics, there are unique characteristics of Islamic community-based enterprise that are not found in conventional literature. The authors contribute to uncovering new variant of the idea of Islamic entrepreneurship and community. This study reveals the birth of the idea of an Islamic community-based enterprise as a breakthrough concept that integrates entrepreneurship, community functions and Islamic values. This research also opens a form of Islamic entrepreneurship which in previous studies is more prominent in the individual perspective.
The Impact of Financial Management Behavior, Locus of Control, and Religiosity Toward Investment Decisions During Covid-19 Pandemic: A Study of Genta Muallaf Community in Bali
Authors: Astuti Rahma Yudi , Suyanto Suyanto , Falah Diajeng Nurul , Imtihanah Ani Nurul
Published: September 2023

The Covid-19 pandemic has affected many economic sectors to decline; one of them is investment. However, this sector is still becoming the center of attention especially for investors. Several factors role and influence the emotional attitudes in investment decision-making such as financial management behavior, locus of control, and religiosity. This study aims to determine the impact of financial management behavior, locus of control, and religiosity in investment decision-making during the Covid-19 pandemic. This was quantitative research that included Genta Muallaf community as the subject. The data were collected by distributing questionnaires, then were analyzed using the IBM SPSS 20 test tool. The results showed that financial management behavior did not fully affect the investment decision-making, while locus of control partially influenced the investment decision-making since both internal and external control factors greatly influenced the human situation itself, and religiosity also did not fully affect the investment decision-making during the Covid-19 pandemic since religious aspects have not been fully implemented in this community. Therefore, it is necessary to further make the financial management behavior as a proposed medium for it can influence more in investment decision-making such as: age, education, and culture aspects. Especially, Genta Muallaf community is expected to be able to foster the society through holding on Islamic law, to manage its financial based on needs instead of desires, and most importantly to always remember God in every decision-making.
RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
Authors: Necarsulmer Julie , Simon Jeremy , Evangelista Baggio , Chen Youjun , Tian Xu , Nafees Sara , Gonzalez Ariana Marquez , Jiang Huijun , Wang Ping , Ajit Deepa , Nikolova Viktoriya , Harper Kathryn , Ezzell Jennifer , Lin Feng-Chang , Beltran Adriana , Moy Sheryl , Cohen Todd
Published: September 2023

TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic-acid binding protein TDP-43 and subsequent neuronal dysfunction. Here, we developed endogenous models of sporadic TDP-43 proteinopathy based on the principle that disease-associated TDP-43 acetylation at lysine 145 (K145) alters TDP-43 conformation, impairs RNA-binding capacity, and induces downstream mis-regulation of target genes. Expression of acetylation-mimic TDP-43K145Q resulted in stress-induced nuclear TDP-43 foci and loss of TDP-43 function in primary mouse and human induced pluripotent stem cell (hiPSC)-derived cortical neurons. Mice harboring the TDP-43K145Q mutation recapitulated key hallmarks of FTLD, including progressive TDP-43 phosphorylation and insolubility, TDP-43 mis-localization, transcriptomic and splicing alterations, and cognitive dysfunction. Our study supports a model in which TDP-43 acetylation drives neuronal dysfunction and cognitive decline through aberrant splicing and transcription of critical genes that regulate synaptic plasticity and stress response signaling. The neurodegenerative cascade initiated by TDP-43 acetylation recapitulates many aspects of human FTLD and provides a new paradigm to further interrogate TDP-43 proteinopathies.
Confusion and contamination of 8.2 ka cold climate records caused by the Storegga tsunami in the Nordic Seas
Authors: Bondevik Stein , Risebrobakken Bjørg , Gibbons Steven , Rasmussen Tine , Løvholt Finn
Published: September 2023

Since the end of the last ice age, no cold snap rivals the one dated to 8200 years ago. Its oceanic response has been reconstructed in part from sediments in the Norwegian Sea and North Sea. Here we show that these sediments have been reworked by currents generated by the Storegga tsunami, dated to the coldest decades of the 8.2 ka event. From a new simulation of the Storegga tsunami we calculated the maximum flow velocity to be 2–5 m/s on the shelf offshore western Norway and in the shallower parts of the North Sea, and up to about 1 m/s down to a water depth of 1000 m. We re-investigated sediment core MD95-2011, from which a large and abrupt 8.2 ka cooling had been inferred, and found the cold-water foraminifera to be re-deposited and 11,000 years of age. Oxygen isotopes of the recycled foraminifera and the content of sand grains, thought to be dropped from ice bergs, might have led to an interpretation of a too large and dramatic climate cooling. Our simulations imply that large parts of the sea floor in the North Sea and Norwegian Sea might have been reworked by currents during the Storegga tsunami.
Systemic inflammatory regulators and risk of chronic periodontitis: A two-sample Mendelian randomization study
Authors: Wang Zheqin , Wang Shengnan , Zhang Jinming , Hu Min
Published: September 2023

Background
To investigate the bidirectional causal relationship between systemic inflammatory regulators and chronic periodontitis.
Methods
We conducted a bidirectional two-sample Mendelian randomization (MR) study of the relationship between systemic inflammatory modifiers and chronic periodontitis using inverse variance weighting, weighted median, and MR‒Egger regression. The GWAS data included information on 41 inflammatory regulators in 8293 individuals and chronic periodontitis in 456,348 individuals (950 cases and 455398 controls).
Results
Increased systemic granulocyte colony-stimulating factor (GCSF) levels were found to be a risk factor for chronic periodontitis (odds ratio = 1.564, 95% confidence interval = (1.137, 2.150), P = 0.006), and chronic periodontitis resulted in decreased systemic stem cell growth factor beta (SCGFb) levels (beta = − 0.11, 95% confidence interval = (− 0.18, − 0.04), P = 0.001).
Conclusions
Our results suggest a potential causal relationship between elevated GCSF levels and an increased risk of chronic periodontitis, as well as a possible causal relationship between an increased risk of chronic periodontitis and elevated SCGFb levels.
Inhibition of soluble epoxide hydrolase induces POTCs to enhance the dentin-pulp complex regeneration mediated by crosstalk between vascular endothelial cells and dental pulp stem cells
Authors: Kongling Wenyao , Li Juanjuan , Bai Yuwen , Xu Shaoyang , Zhang Lin , Chen Weixian , Gao Lu , Wang Fu
Published: September 2023

Background
Revascularization and restoration of normal pulp-dentin complex are important for tissue-engineered pulp regeneration. Recently, a unique periodontal tip-like endothelial cells subtype (POTCs) specialized to dentinogenesis was identified. We have confirmed that TPPU, a soluble epoxide hydrolase (sEH) inhibitor targeting EETs metabolism, promotes bone growth and regeneration by angiogenesis and osteogenesis coupling. We hypothesized that TPPU could also promote revascularization and induce POTCs to contribute to pulp-dentin complex regeneration. Here, we in vitro and in vivo characterized the potential effect of TPPU on the coupling of angiogenesis and odontogenesis and investigated the relevant mechanism, providing new ideas for pulp-dentin regeneration by targeting sEH.
Methods
In vitro, the effects of TPPU on the proliferation, migration, and angiogenesis of dental pulp stem cells (DPSCs), human umbilical vein endothelial cells (HUVECs) and cocultured DPSCs and HUVECs were detected using CCK8, wound healing, transwell, tube formation and RT-qPCR. In vivo, Matrigel plug assay was performed to outline the roles of TPPU in revascularization and survival of grafts. Then we characterized the VEGFR2 + POTCs around odontoblast layer in the molar of pups from C57BL/6 female mice gavaged with TPPU. Finally, the root segments with DPSCs mixed Matrigel were implanted subcutaneously in BALB/c nude mice treated with TPPU and the root grafts were isolated for histological staining.
Results
In vitro, TPPU significantly promoted the migration and tube formation capability of cocultured DPSCs and HUVECs. ALP and ARS staining and RT-qPCR showed that TPPU promoted the osteogenic and odontogenic differentiation of cultured cells, treatment with an anti-TGF-β blocking antibody abrogated this effect. Knockdown of HIF-1α in HUVECs significantly reversed the effect of TPPU on the expression of angiogenesis, osteogenesis and odontogenesis-related genes in cocultured cells. Matrigel plug assay showed that TPPU increased VEGF/VEGFR2-expressed cells in transplanted grafts. TPPU contributed to angiogenic-odontogenic coupling featured by increased VEGFR2 + POTCs and odontoblast maturation during early dentinogenesis in molar of newborn pups from C57BL/6 female mice gavaged with TPPU. TPPU induced more dental pulp-like tissue with more vessels and collagen fibers in transplanted root segment.
Conclusions
TPPU promotes revascularization of dental pulp regeneration by enhancing migration and angiogenesis of HUVECs, and improves odontogenic differentiation of DPSCs by TGF-β. TPPU boosts the angiogenic–odontogenic coupling by enhancing VEGFR2 + POTCs meditated odontoblast maturation partly via upregulating HIF-1α, which contributes to increasing pulp-dentin complex for tissue-engineered pulp regeneration.
Testing the effectiveness and acceptability of online supportive supervision for mental health practitioners in humanitarian settings: A study protocol for the Caring for Carers Project
Authors: Wells Ruth , Acarturk Ceren , Mozumder Muhammad Kamruzzaman , Kurt Gülşah , Klein Louis , Lekkeh Salah , Beetar Ammar , Jahan Sabiha , Almeamari Fatema , Faruk Omar , McGrath Michael , Alam Syeda Fatema , Alokoud Mustafa , Dewan Ranak , Vecih Ahmed El , El-Dardery Hafsa , Hadzi-Pavlovic Dusan , Hammadi Hanan , Hamoud Mounir Al Shekh , Hasan Tasdik , Joshi Rohina , Kothaa Sowmic , Lamia Fauzia Kabir Chowdhury , Mastrogiovanni Chiara , Najjar Hussam , Nemorin Shaun , Nicholson-Perry Kathryn , Prokrity Tahmina Sarker , Saidyousef Rania , Tawakol Mamoun , Uygun Ersin , Wong Scarlett , Zarate Ariel , Steel Zachary , Rosenbaum Simon
Published: September 2023

Background Local humanitarian workers in low and middle-income countries must often contend with potentially morally injurious situations, often with limited resources. This creates barriers to providing sustainable mental health and psychosocial support (MHPSS) to displaced individuals. Clinical supervision is an often neglected part of ensuring high-quality, sustainable care. The Caring for Carers (C4C) project aims to test the effectiveness and acceptability of online group-based supportive supervision on the well-being of MHPSS practitioners, as well as service-user-reported service satisfaction and quality when working with displaced communities in Türkiye, Syria, and Bangladesh. This protocol paper describes the aim, design, and methodology of the C4C project.Method A quasi-experimental, mixed-method, community-based participatory research study will be conducted to test the effectiveness of online group-based supportive clinical supervision provided to 50 Syrian and 50 Bangladeshi MHPSS practitioners working with Syrian and Rohingya displaced communities. Monthly data will be collected from the practitioners and their beneficiaries during the active control (six months) and supervision period (16 months over two terms). Outcomes are psychological distress (Kessler-6), burnout (the Copenhagen Burnout Inventory), compassion fatigue, compassion satisfaction, and secondary traumatic stress (Professional Quality of Life Scale), perceived injustice, clinical self-efficacy (Counseling Activity Self-Efficacy Scale), service satisfaction, and quality (Client Satisfaction Questionnaire and an 18-item measure developed in this project). A realist evaluation framework will be used to elucidate the contextual factors, mechanisms, and outcomes of the supervision intervention.Discussion There is a scarcity of evidence on the role of clinical supervision in improving the well-being of MHPSS practitioners and the quality of service they provide to displaced people. By combining qualitative and quantitative data collection, the C4C project will address the long-standing question of the effectiveness and acceptability of clinical supervision in humanitarian settings.
Assessment of Entrustable Professional Activities among Dutch Endocrine Supervisors
Authors: Laat J. M. , Horst-Schrivers A. N.A. van der , Appelman-Dijkstra N. M. , Bisschop P. H. , Dreijerink K. M.A. , Drent M. L. , de Klauw M. M. van , De Ranitz W. L. , Stades A. M.E. , Stikkelbroeck N. M.M.L. , Timmers H. J.L.M. , Cate O. ten
Published: September 2023

Objective
Entrustable Professional Activities (EPAs) are an important tool to support individualization of medical training in a competency-based setting and are increasingly implemented in the clinical speciality training for endocrinologist. This study aims to assess interrater agreement and factors that potentially impact EPA scores.
Design
A case-vignette study using standardized written cases
Methods
Case vignettes (n=6) on the topics thyroid disease, pituitary disease, adrenal disease, calcium and bone disorders, diabetes mellitus, and gonadal disorders were written by two endocrinologists and a medical education expert and assessed by endocrinologists experienced in the supervision of residents in training.
Primary outcome is the interrater agreement of entrustment decisions for endocrine EPAs among raters. Secondary outcomes included the dichotomous interrater agreement (entrusted vs. non-entrusted), and an exploration of factors that impact decision-making.
The study protocol was registered and approved by the Ethical Review Board of the Netherlands Association for Medical Education (NVMO-ERB # 2020.2.5).
Results
Nine endocrinologists from six different academic regions participated. Overall, the Fleiss Kappa for the EPA level was 0.11 (95% CI: 0.03-0.22) and for the entrustment decision 0.24 (95% CI 0.11-0.37). Of the five features that impacted the entrustment decision, capability was ranked as the most important by a majority of raters (56%- 67%) in every case.
Conclusions
There is a considerable discrepancy between the EPA levels assigned by different raters. These findings emphasize the need to base entrustment decisions on multiple observations, made by a team of supervisors and enriched with factors other than direct medical competence.
Optimization methods for the distortion of thin-walled box girders and investigation of distortion effects
Authors: Wang Zhaonan
Published: September 2023

To investigate the distortion process of thin-walled box girders, three commonly used methods based on energy variational calculus and static balance analysis are optimized. A generalized analytical formula for box-girder distortion research is derived, and a fourth-order distortion control differential equation is obtained. Typical numerical examples are used to verify and compare the three methods. The results show that the value of distortional warping normal stress calculated by the optimized methods is slightly different from the literature values and that the maximum error between methods does not exceed 5.39%. The calculation results of Method 2 and Method 3 are similar. The values of the geometric distortion characteristics calculated by the three methods are related to the cross-sectional form of the box girder and the distortion analysis process, and the calculated values are not unique. The absolute value of the peak normal stress of distortion on the top plate of a thin-walled box girder with a cantilever plate is smaller than that on the bottom plate. Under a concentrated distortion load, the distribution of the distortion deformation along the length of a simply supported box girder with only end diaphragm is not consistent, and there is reverse deformation near the beam end.
The shell proteome of the deep-sea barnacle Bathylasma hirsutum and the convergency in barnacle and molluscan shell proteins
Authors: Xu Yu-Tao , Taylor James , Liu Hao-Cheng , Dreyer Niklas , Cho Qian-Qian , Zhang Yu , Guo Shi-Feng , Brix Saskia , Wong Yue Him
Published: September 2023

BackgroundAs a group of sessile crustaceans that were being misclassified as mollusks by Carl Linnaeus, barnacles produce calcareous shell plates which, in most species, are permanently attached to the substratum. As biomineralization has independently evolved in multiple marine invertebrate taxa, a key question is how biomineralization has driven the evolution of genetic toolkits underlying shell formation. Here, we explore the shell proteome of the deep-sea acorn barnacleBathylasma hirsutum(Hoek, 1883) using an integrated transcriptomic-proteomic approach and compare the properties of barnacle shell proteins with molluscan shell matrix proteins.ResultsWe identified 31B. hirsutumbarnacle shell proteins (BSPs), including a series of key biomineralization proteins, such as carbonic anhydrase and C-type lectin. More than half of barnacle specific shell proteins (BSSPs) exhibit unknown functions. The amino acid composition of these BSSPs were biased toward A, D, E, G, S, P and Q, and were acidic and hydrophilic. Almost all BSSPs were detected with repetitive low complexity domains. Similar to molluscan shell matrix proteins, RLCDs in D-, and E-rich BSSPs constituted up to 50% amino acid of the whole protein. RLCDs in Q-rich proteins also exhibited similarity to a Q-rich abalone shell matrix protein and an insect cuticle protein.ConclusionFrom theB. hirsutumshell proteome, certain proteins such as carbonic anhydrase, C-type lectin, and peroxidase were implicated in shell formation or protein cross-linking across sessile invertebrate taxa. Despite the lack of sequence homology, D- and Q-rich BSSPs share similar features with molluscan shell matrix proteins in sequence redundancy, amino acid bias and thereby protein isoelectric point and hydropathy. Such convergence may reflect that similar selection pressures shape the molecular evolution of biomineralization and shell formation genes in marine invertebrates.
The Characteristic of infection in BA.2, BA.5 to BF7：A retrospective study
Authors: Lyu Hongxin , Xiong Huawei , Liu Lingyu , Feng Yunlong
Published: September 2023

Background
Omicron has become the dominant SARS-CoV-2 variant worldwide. While comparisons of infection characteristics in various evolutionary variants remain scarce, it is essential to analyse the evolution and make important additions to the disease spectrum.
Methods
We used a retrospective case study to collect 802 cases of primary infection with BA.2, BA.5, and BF.7 sub-variants in three SAR-COV 2 outbreaks in China and identified infection characteristics using demographic, laboratory examinations, and clinical data. All data were analyzed using the Chi-square test and One-way ANOVA, with p < 0.05 as a statistically significant criterion.
Results
The results showed that the proportion of symptomatic cases of infection by BA.2, BA.5, BF.7 were 80.9%, 70.5%, and 61.4%. Moreover, the initial asymptomatic cases without clinical progression among the three variants were 41.8%, 35.9%, and 57.5%, respectively. Our statistical results suggest that mutations confer more asymptomatic infections and shorter incubation periods, sequence intervals, and HT. In the population receiving the booster vaccine, a longer duration of vaccination to positive indicates lighter symptoms. The emergence of sub-mutant strains has led to a decrease in the proportion of symptoms in the elderly and the clinical severity and viral load of those infected at lower ages. Gender differences caused by mutations were more commonly manifested in neurological symptoms such as myalgia. The CT value of the initial positive test reflected the severity of the disease in the BF.7 infected individuals in contrast to the early variants. All manifestations of infection with BF.7 became milder compared to the previous sub-variants.
Conclusion
The effect of the variation was gradually weakening but showed differences in ages and genders. Although the mutation causes immune evasion, the vaccine significantly reduces symptoms and disease duration as the mutation appears. More attention should be paid to the evolution of mutant strains to prevent a larger epidemic.
Constructing Population-Specific Atlases from Whole Body MRI: Application to the UKBB
Authors: Starck Sophie , Sideri-Lampretsa Vasiliki , Ritter Jessica , Zimmer Veronika , Braren Rickmer , Mueller Tamara , Rueckert Daniel
Published: September 2023

Population atlases are commonly utilised in medical imaging to facilitate the investigation of variability across populations.
Such atlases enable the mapping of medical images into a common coordinate system, promoting comparability and enabling the study of inter-subject differences.
Constructing such atlases becomes particularly challenging when working with highly heterogeneous datasets, such as whole-body images, where subjects show significant anatomical variations.
In this work, we propose a pipeline for generating a standardised whole-body atlas for a highly heterogeneous population by partitioning the population into meaningful subgroups.
We create six whole-body atlases that represent a healthy population average using magnetic resonance (MR) images from the UK Biobank dataset. We furthermore unbias them, and this way obtain a realistic representation of the population.
In addition to the anatomical atlases, we generate probabilistic atlases that capture the distributions of abdominal fat and five abdominal organs across the population.
We demonstrate different applications of these atlases, using the differences between subjects with medical conditions such as diabetes and cardiovascular diseases and healthy subjects from the atlas space.
With this work, we make the constructed anatomical and label atlases publically available and anticipate them to support medical research conducted on whole-body MR images. They are available for download at this address (https://zenodo.org/record/8226039)
The association of urinary chlorpyrifos, paraquat, and cyproconazole levels with the severity of fatty liver based on MRI
Authors: Ma Peiqi , Gao Hongliang , Shen Ning , Zhang Lei , Zhang Yang , Zheng Kai , Xu Boqun , Qin Jian , He Jian , Xu Tao , Li Yan , Wu Jing , Yuan Yushan , Xue Bin
Published: September 2023

Background: The objective of this study was to detect the urinary levels of chlorpyrifos, paraquat, and cyproconazole in residents living in Fuyang City and to analyze the correlation between these urinary pesticides levels and the severity of fatty liver disease (FLD).
Methods: All participants’ fat fraction (FF) values were recorded by MRI (Magnetic resonance imaging). First-morning urine samples were collected from 53 participants from Fuyang Peoples’Hospital. The levels of three urinary pesticides were measured using β-glucuronidase hydrolysis followed by a high-performance liquid chromatography-tandem mass spectrometry-based (LC-MS) method. The results were analyzed by using Pearson correlation analysis and binary logistic regression analysis to reveal the correlation between three urinary pesticides and the severity of fatty liver.
Results: 53 individuals were divided into 3 groups based on the results from MRI, with 20 cases in the normal control group, 16 cases in the mild fatty liver group, and 17 cases in the moderate and severe fatty liver group. Urinary chlorpyrifos level was increased along with the increase of the severity of fatty liver. Urinary paraquat level was significantly higher both in the low-grade fatty liver group and moderate & serve grade fatty liver group compared with the control group but there was no significant difference between the low-grade fatty liver group and moderate & serve grade fatty liver group. No significant differences in urinary cyproconazole levels were observed among the three groups. Furthermore, urinary chlorpyrifos and paraquat levels were positively correlated with FF value. Binary logistic regression analysis showed that chlorpyrifos was the risk factor that may be involved in the development of FLD and ROC curve analysis showed that chlorpyrifos and paraquat may serve as potential predictors of FLD.
Conclusion: The present findings indicate urinary chlorpyrifos and paraquat were positively correlated with the severity of fatty liver. Moreover, urinary chlorpyrifos and paraquat have the potential to be considered as the predictors for development of FLD. Thus, this study may provide a new perspective from the environmental factors for the diagnosis, prevention, and treatment of FLD.
Development of the EVIBEC Learning Outcomes Framework to support the delivery of evidence-based practice curricula in health care professional programmes: a Codesign Approach
Authors: Redmond Catherine , Farrell Robin , Cunningham Caitriona , Dineen Andrea , Foley Shane , O`Donnell Deirdre , O`Reilly Sharleen , Stokes Diarmuid , O`Neill Emma
Published: September 2023

Background
All healthcare professional education programmes must adopt a systematic approach towards ensuring graduates achieve the competencies required to be an evidence-based practitioner. While a list of competencies for evidence-based practice exist, health care educators continue to struggle with effectively integrating these competencies into existing curriculum. The purpose of this project was to develop an open access cross-discipline, learning outcomes framework to support educators in integrating the teaching, learning and assessment required to ensure all graduates of health care professional programmes can achieve the necessary evidence-based practice competencies.
Methods
An interdisciplinary project team of 7 health care professions educators and a librarian completed a review of the health professions literature on the teaching and assessment of evidence-based practice. The literature coupled with the teams’ collective experiences in health professions evidence-based education and research were used to identify relevant teaching, learning and research frameworks to inform the project design. The guide and toolkit for experience-based co-design developed by the NHS Institute for Innovation and Improvement was adopted for this study. A four-step approach involving three online interactive and participatory co-design workshops and a national stakeholder validation workshop was designed. Students (n = 33), faculty (n = 12), and clinical educators (n = 15) contributed to the development and validation of the EVIBEC learning outcomes framework through this co-design approach.
Results
Through a rigorous, systematic co-design process the EVIBEC Learning Outcomes Framework was developed. This framework consists of a series of student-centred learning outcomes, aligned to EBP competencies, classified according to the 5 As of EBP and mapped to the cognitive levels of Bloom’s taxonomy. Associated learning activities for each step of EBP are suggested.
Conclusions
Co-design was an effective method to develop a learning outcomes framework and associated learning activities to support integration and delivery of evidence-based practice across health care professions education programmes. Furthermore, outcomes from the co-design workshops supported the use of a spiral curriculum design where knowledge and skills are introduced and revisited at increasing levels of complexity over time coupled with the use of active learning and assessment activities to deliver evidence-based practice curriculum.
The effect of social networking sites on resistance training behaviour among college students: application of a mixed model based on the theory of planned behaviour
Authors: Wei Wei , Su RongHai , Chen Lin , Meng Meng , Zheng Rongrong
Published: September 2023

Background
The purpose of this study is to explore the effect of social networking sites (SNS) on college students’ participation in resistance training, with a specific focus on the mediating role of planning and emotion in bridging the intention-behaviour gap.
Methods
Three hundred fifty-six college students (215 males and 141 females, with an average age of 21.37 ± 2.40 years) from 17 universities in China who regularly participate in resistance training were surveyed via questionnaires. The data was analysed using the Maximum Likelihood Estimation (MLE) in AMOS 20.0, and the planned behaviour mixed model was tested using a structural equation model.
Results
Three main findings emerged from the study: 1) SNS had a positive effect on college students' participation in resistance training; 2) Intention and behaviour towards resistance training among college students were influenced by planning and positive emotion as mediators; 3) College students' participation in resistance training is positively affected by rational cognition.
Conclusions
The mixed model of planned behaviour examines how SNS influences college students' intentions and behaviour toward resistance training. By combining the advantages of rational thinking with basic emotional instincts, this model provides a more accurate prediction of college students' intentions and behaviours in resistance training.
Advanced lung cancer inflammation index is associated with mortality in peritoneal dialysis patients
Authors: Ren Zhouhao , Wu Jiaying , Shen Shuijuan
Published: September 2023

Background
There is still a very high morbidity and mortality rate for patients undergoing peritoneal dialysis (PD). The advanced lung cancer inflammation index (ALI) has been demonstrated to be associated with prognosis in multiple types of cancers. Similar to cancer, systemic chronic low-grade inflammation is one of the distinguishing features of PD patients. Therefore, we aimed to investigate the relationship between ALI and all-cause and cardiovascular mortality in PD patients.
Methods
277 patients who started PD at Shaoxing People's Hospital between 1 January 2013 and 31 December 2020 were recruited and followed up until 1 July 2023. The dose-response relationship between ALI and mortality was described by restricted cubic splines. Receiver operating characteristic (ROC) analysis was performed and the area under the curve (AUC) was calculated to determine the predictive power of ALI for all- cause mortality and CVD mortality. Kaplan-Meier curves and multivariate cox regression analyses were used to assess the association between ALI and all-cause mortality and cardiovascular mortality.
Result
During the median follow-up of 40.50 months (interquartile range, 26.42~59.77 months), a total of 55 patients died and 31 of them died due to cardiovascular disease. Kaplan-Meier curves showed that patients in the low ALI group had significantly lower cumulative survival rate and cardiovascular cumulative survival rate than those in the high ALI group (all P < 0.001). After correcting for confounders, the risk of all-cause mortality and cardiovascular death was significantly higher in the low ALI group than in the high ALI group [hazard ratio (HR) 1.944, 95% confidence interval (Cl) 1.068~3.540, P = 0.030, and HR 2.672, 95% Cl 1.188~6.009, P = 0.017, respectively].
Conclusion
A lower ALI is an independent risk factor for all-cause mortality and cardiovascular mortality in PD patients. ALI may be an effective indicator for predicting outcomes in PD patients.
Association Between Serum Gamma-Glutamyl Transferase and Alkaline Phosphatase with Presence of Premature Coronary Artery Disease: Findings from Khuzestan Comprehensive Health Study (KCHS)
Authors: Khaboushan Alireza Soltani , Masoudkabir Farzad , Jalali Arash , Vasheghani-Farahani Ali , Mohammadi Zahra , Mard Ali , Rahimi Zahra , Hashemi Farnaz , Malihi Reza , Danehchin Leila , Abolnezhadian Farhad , Paridar Yousef , Mir-Nasseri Mohammad Mahdi , Cheraghian Bahman , Shayesteh Ali Akbar , Poustchi Hossein
Published: September 2023

Background
Coronary artery disease has remained the leading cause of death worldwide. Premature coronary artery disease (PCAD) is defined as the incidence of coronary artery disease in males ≤ 45 and females ≤ 55. This study aimed to investigate the association between the concentrations of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) with the presence of PCAD for the first time in a large general population in a developing country.
Methods
A total of 20,542 from the Khuzestan Comprehensive Health Study participants were entered into the study based on the inclusion and exclusion criteria. The association of the GGT and ALP levels with the presence of PCAD was analyzed with multiple logistic regression models adjusted for gender, dyslipidemia, triglyceride concentration, cigarette smoking, opium consumption, hypertension, diabetes mellitus, and age. Moreover, the receiver operating characteristic (ROC) was used to assess the predictive power of GGT and ALP for PCAD.
Results
While in univariate analyses both ALP and GGT were significantly associated with the presence of PCAD [GGT: odds ratio (OR), 1.008; 95% confidence interval (CI), 1.005–1.011; p-value < 0.0001; ALP: OR, 1.003; CI, 1.002–1.004; p-value < 0.0001], after adjusting for confounders, the associations were no longer significant (GGT p-value = 0.177; ALP p-value = 0.963). However, the addition of the GGT to the conventional cardiovascular risk factors improved the predictive value of the model for the presence of PCAD in females (p-value < 0.05).
Conclusions
In conclusion, although ALP showed no independent association with PCAD, adding GGT to conventional cardiovascular risk factors could significantly improve the prediction of PCAD in female participants.
Expression and Application of Computer Image Technology in Visual Communication Design in Fashion Design
Authors: Wu Wei , Li Kui
Published: September 2023

After years of development, clothing design is full of artistic sense, and clothing has developed from traditional clothing to a kind of artistic clothing. The use of Visual Communication (VC) design in clothing design can creatively combine words, symbols, and graphics, but it is difficult to deal with graphics in traditional clothing design. In this article, computer image technology was applied to VC design in clothing design, and the effect of clothing design was improved through the accurate processing of clothing graphics and symbols. This article compared traditional VC design and VC design based on computer image technology in clothing design. The experimental results showed that the average VC effect of traditional VC design and VC design based on computer image technology was 75.98% and 83.72% respectively in life clothing. In fashion clothing, the average VC effect of traditional VC design and VC design based on computer image technology was 76.58% and 85.66% respectively. Therefore, VC design in clothing design using computer image technology can improve the VC effect.
The Effect of Pterygium on Front and Back Corneal Astigmatism and Aberrations in Natural-Light and Low-Light Conditions
Authors: xu weiwei , li xia
Published: September 2023

Background
To investigate the effect of different sizes of pteryium on the front and back corneal topography, corneal refractive changes and aberrations in natural-light and low-light conditions.
Methods
Sixty subjects with unilateral primary nasal pterygium were enrolled in this study. All the patients’ uncorrected, best spectacle-corrected visual acuities, corneal topographic aberration data in 3mm and 7mm areas were collected. The pterygia sizes were evaluated by the slit-lamp photography and Sirius Scheimpflug Analyzer.
Results
The front topographic astigmatism values, corneal total abbertions, and higher-order aberrations in 3mm and 7mm areas were higher in the pterygia group than those in the control group. The ptergia horizontal length and thickness were moderately to strongly correlated with astigmatism and RMS of aberrations, while pterygia vertical length showed no or just mild correlation with the cornCompared to the readings in 3mm area, the front and back corneal astigmatism and aberrations were larger in 7mm area.
Conclusions
Pterygia led to visual impairment by inducing astigmatism and aberrations. In low-light condition, the visual function were worse because of increased corneal astigmatism values and aberrations.
Emerging spectrum of DOCK8 deficiency in children and challenges associated with providing treatment: experience from a tertiary referral centre in India
Authors: ganesan kavitha , duraisamy suresh , nair anupama , muthukumar vijayshree , swaminathan venkateswaran vellaichamy , jayakumar indira , krishna vidya , UPPULURI RAMYA , raj revathi
Published: September 2023

The study describes the course of children with DOCK8 deficiency, their stormy clinical course, discrete infection pattern, and challenges during the treatment. The retrospective study included children up to 18 years of age diagnosed to have genetically proven DOCK8 deficiency from January 2013 to January 2023. A total of nine children were included, with a median age of five years. Clinical presentations included eczema (2/9), viral infections (4/9), recurrent sinopulmonary infections (3/9), impetigo (2/9), autoimmune hemolytic anemia (1/9) and Epstein-Barr virus driven malignancy (1/9). Other infections noted were molluscum contagiosum in two children, cytomegalovirus colitis in one child, and recurrent Klebsiella pneumoniae meningitis. The outcomes of hematopoietic stem cell transplantation (HSCT) remained poor (n=5, three haploidentical HSCT, one each matched family and unrelated donor HSCT), due to early and refractory viral reactivation, with 17,00,000 copies of cytomegalovirus in one child and 8,53,95,600 copies of adenovirus in another child. Secondary late graft failure was noted in one child, two years following a matched sibling donor HSCT. The one who underwent a matched unrelated donor HSCT was doing well and was infection free. The clinical course without HSCT had been stormy, as seen in a child with Burkitt's lymphoma, who succumbed to refractory cytomegaloviral meningoencephalitis despite being in remission following chemotherapy. DOCK8 deficiency patients are included in the Hyper IgE syndrome spectrum. HSCT poses significant challenges in these children with refractory viral infections. Collaborative work and research are required to decide the optimal care for these children to guide better treatment outcomes.
Biopesticidal Activity for Controlling Root Rot and Root Knot Infection of Green Beans under Natural Field Conditions Utilizing Biowastes
Authors: Nawwar Galal , Othman Hoda Sabry , Abdel-Kader Mokhtar , El-Mougy Nehal S.
Published: September 2023

The current study investigates using of alkaline black liquor (ABL), a byproduct of rice straw pulping, to create a bio-active formulation that can inhibit the growth of soilborne plant pathogens. ABL was first treated to precipitate lignin, silica, and fatty acids as a calcium complex (Ca-LSF). The resulting effluent was used to digest chicken feathers under mild conditions. The resulting protein hydrolysate was added to Ca-LSF complex affording a novel formulation to be evaluated against soilborne pathogenic fungi Fusarium oxysporum, Fusarium solani, Rhizoctonia solani, and Sclerotium rolfsii, as well as the nematode Meloidogyne incognita, the causal organisms of wilt, root rot and root knot diseases. The prepared formulation showed strong inhibitory effect against R. solaniand affected viability of M. incognita. This effect increased with increasing concentration, up to 4%, which completely inhibited fungal growth. It was also examined under field conditions, where it reduced root rot and root knot infection. Application of this formulation as seed dressing showed higher efficacy against root rot and root knot infection than its soil drench treatment, although both treatments were superior to untreated control. The presented safe, cost-effective, and eco-friendly formulation could be used to control a wide range of soilborne plant pathogens.
Middle East North Africa (MENA) and Indian Thar desert dust storms pathway as game changer of Phosphorus depositional pattern in Asia's largest Grassland
Authors: sharma Seema , Dey Rupak , THAKKAR MAHESH , Sarangi Ranjit , Chowdhury Abhiroop , Naz Aliya
Published: September 2023

Dust particles make up almost all of the atmospheric phosphorus, which accounts for 82% of the total phosphorus in the world. Phosphorus (P) is an important nutrient for terrestrial ecosystems, playing a critical role in influencing primary productivity and hence ecosystem dynamics. The deposition of airborne dust, particularly from arid and semi-arid regions, has been recognized as a significant source of phosphorus input in distant ecosystems. The study area, the Banni Plains, is a semi-arid ecosystem with a unique geological history, that has suffered from degradation due to varied natural and anthropogenic reasons. It is located in arid tract of western India (23º 19' to 23º52' N latitude and 68º 56' to 70º32' E longitude).Soil samples were collected from 10*10 km grid locations in the grassland before, after 48 hours, and 20 days after a cyclonic storm, Biporjoy, which hit the region in June, 2023. Statistical analyses (Shapiro-Wilk normality and Kruskalwallis H test) were performed on the data to assess the differences in phosphorus concentrations among the phases. To examine the long-range transport of dust-borne phosphorus and its subsequent deposition in the target grassland, we employed an interdisciplinary approach that integrated satellite imagery and ground-based measurements. Spatial and temporal variations in dust emissions were assessed using satellite remote sensing data, while ground truthing was done for phosphorus content analysis using standard protocols. The aerosol data from MERRA-2 for the past 40 years were used to examine the relationship between aerosol concentrations and wind direction and speed. Our findings reveal that the Middle East, North Africa, and Thar Deserts significantly contribute to the phosphorus deposition in the target grassland during specific seasons. The SW cyclone ‘Biporjoy’ that followed the same track of aerosols loading (MENA) had a landfall on this zone (June 16, 2023) affected the P depositional patterns. The pre cyclone, post cyclone and 20 DAC (Days after Cyclone), had AP values 20.15, 20.54 and 24.06 respectively. However, TP values were 45.81 ± SE = 1.73, 60.95 ± SE = 1.39 and 61.98 ± SE = 1.40 respectively. The highest TP values was in phase 3 (20 DAC phase) 61.89 ± SE = 1.40. Dust storms and other atmospheric circulation patterns were found to play a pivotal role in facilitating the long-range transport of phosphorus-laden dust particles from these source regions to the target grassland. Ultimately, our research contributes to the broader understanding of global nutrient cycling and land-air interactions, enabling informed decision-making for the conservation and sustainable management of terrestrial ecosystems.
Processing characteristics and loading principle on micro blanking of cavitation jet
Authors: Wang Yun , Zhu Cong , Li Fuzhu , Yu Chao , Chen Shijian , Wu Jingyi
Published: September 2023

This study proposes a new technology of flexible micro blanking with cavitation jet to improve the quality of micro blanking parts. We simulated the cavitation jet, obtained the change of its meteorological volume fraction, and verified the high- pressure phenomenon caused by cavitation collapse, which is used to achieve processing. Then, we investigated the blanking form ability of cavitation jet on T2 copper foils to cope with different shapes. The impact of the incident pressure of cavitation jet and targeted distance on the micro blanking form ability is studied, and the experimental results are correlated with the simulation. Also, we observed a linear relation between the critical blanking thickness and blanking size of T2 copper foil. Through the characterization of the experimental results, it is found that the internal stress of the regular polygon-shaped blanking parts is unevenly distributed along the blanking contour during processing, which is easy to cause the material to tear and produce defects like flaws and incomplete forming. On the other hand, the internal stresses of the circular blanking parts are evenly distributed along the blanking contour, which shows that the blanking forming has good quality. This processing technology is different from traditional plastic micro blanking processing, the cut edge morphology of micro blanking parts under cavitation jet technology is mainly bending and pulling, without obvious shearing marks. Under moderate incident pressure, the cut edge of the blanking part has few pulling marks and small burrs, and has good and uniform blanking quality.
Semi-Empirical Model for Henry’s Law Constant of Noble Gases in Molten Salts
Authors: Lee Kyoung , Williams Wesley , Mcfarlane Joanna , Kropaczek Dave , de Wet Dane
Published: September 2023

Henry's law constant, which describes the proportionality of dissolved gas to partial pressure of free gas in liquid--gas equilibrium systems, can also be applied to mass transport applications. In this work, we investigated an approach for determining the solubility of noble gases in a molten salt liquid utilizing the equilibrium concept of Henry's gas constant. Henry's gas constant is described as a mathematical function dependent on the van der Waals radius of the noble gas and the temperature of the molten salt. The alteration in Gibbs free energy encompasses contributions from both surface and volume energies. Enthalpy and entropy are deduced from these surface and volume energies in the Gibbs free energy formulation. A comparative analysis was conducted between the conventional method and our proposed model. Moreover, useful chemical properties can be determined from examination of surface and volume energies. Our findings provide an accurate and general theory of Gibbs free energy that can be validated experimentally based on the model proposed herein. This work unifies the prediction of Henry gas constant and subsequently the entropy and enthalpy calculation for noble gases in a molten salt solution to a single functional form using van der Waals radius of the gas and temperature of the system. This functional form is then used to perform a multiple regression method to find two parameters corresponding to the surface energy and volume energy. These two parameters are consistent between all combinations of noble gas and molten salt.