bluuebunny/crossref_metadata_2025 huggingface dataset:
Family experiences with palliative care for children at home: a systematic literature review
Authors: Winger Anette , Kvarme Lisbeth Gravdal , Løyland Borghild , Kristiansen Camilla , Helseth Sølvi , Ravn Ingrid H.
Published: October 2020

Background

The main goal of pediatric palliative care (PPC) is to improve or maintain the best possible quality of life (QoL) for the child and their family. PPC can be provided in community health centres, within the specialist health care service and/or in the child’s home. Home is often the preferred place for families, and recommendations state that, whenever possible, the family home should be the centre of care for the child. The aim of this study is to systematically review the experiences and needs of families with children receiving palliative care at home.

Methods

We conducted a systematic review and searched the peer-reviewed databases CINAHL, Embase, PsycInfo and MEDLINE for articles published between January 2000 and October 2019. We included 23 studies emphasising the experience of family members when their child (0–18 years) received palliative care at home. We used a thematic analysis to identify relevant themes in the literature, and synthesised the findings from the different studies.

Results

The review represents the experiences of the families of almost 300 children with life-limiting (LL) and life-threatening (LT) conditions receiving palliative care at home. In general, the children’s mothers are interviewed, and seldom the sick children themselves or their siblings. Most families preferred staying at home since it made it easier to maintain a normal family life, was less stressful for the sick child, and meant that siblings could still attend school and be with friends. Families experienced a range of challenges due to the coordination of care, including a lack of support and adequately skilled staff with appropriate experience. Respite care was needed in order to cope with everyday life. Some studies were not specific concerning the place of care, and some relevant papers may have been omitted.

Conclusions

Families receiving PPC need organised, individualised support from a skilled PPC team. Respite care is necessary in order to manage a demanding home-care situation and parents need support for siblings. Privacy to be a family is a need, and many families need financial support. Future studies should focus on PPC at home in the perspectives of sick children and their siblings.
SUMO proteins in the cardiovascular system: friend or foe?
Authors: Shetty Prithviraj Manohar Vijaya , Rangrez Ashraf Yusuf , Frey Norbert
Published: October 2020

Post-translational modifications (PTMs) are crucial for the adaptation of various signalling pathways to ensure cellular homeostasis and proper adaptation to stress. PTM is a covalent addition of a small chemical functional group such as a phosphate group (phosphorylation), methyl group (methylation), or acetyl group (acetylation); lipids like hydrophobic isoprene polymers (isoprenylation); sugars such as a glycosyl group (glycosylation); or even small peptides such as ubiquitin (ubiquitination), SUMO (SUMOylation), NEDD8 (neddylation), etc. SUMO modification changes the function and/or fate of the protein especially under stress conditions, and the consequences of this conjugation can be appreciated from development to diverse disease processes. The impact of SUMOylation in disease has not been monotonous, rather SUMO is found playing a role on both sides of the coin either facilitating or impeding disease progression. Several recent studies have implicated SUMO proteins as key regulators in various cardiovascular disorders. The focus of this review is thus to summarize the current knowledge on the role of the SUMO family in the pathophysiology of cardiovascular diseases.
Correction to: Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia
Authors: Bai Ju , He Aili , Huang Chen , Yang Juan , Zhang Wanggang , Wang Jianli , Yang Yun , Zhang Pengyu , Zhang Yang , Zhou Fuling
Published: October 2020

An amendment to this paper has been published and can be accessed via the original article.
Correction to: Recent advances in Surface Guided Radiation Therapy
Authors: Freislederer P. , Kügele M. , Öllers M. , Swinnen A. , Sauer T.-O. , Bert C. , Giantsoudi D. , Corradini S. , Batista V.
Published: October 2020

An amendment to this paper has been published and can be accessed via the original article.
Prevalence and risk factors for youth suicidality among perinatally infected youths living with HIV/AIDS in Uganda: the CHAKA study
Authors: Rukundo Godfrey Zari , Mpango Richard Stephen , Ssembajjwe Wilber , Gadow Kenneth D. , Patel Vikram , Kinyanda Eugene
Published: October 2020

Background

Research from high income countries indicates that suicide is a major mental health care concern and a leading cause of preventable deaths among children and adolescents. Proper assessment and management of youth suicidality is crucial in suicide prevention, but little is known about its prevalence and associated risk factors in Sub-Saharan Africa. In low income countries there is an increased risk of suicide among persons with HIV/AIDS even in the presence of the highly active antiretroviral therapy.

Objective

To determine the prevalence of and risk factors for youth suicidality among perinatally infected youth living with HIV/AIDS in Uganda.

Methods

We studied 392 HIV positive children (5–11 years) and adolescents (12–17 years) and their caregivers in Kampala and Masaka districts. Caregivers were administered the suicide assessment section of the MINI International Psychiatric Interview. Socio-demographic characteristics, psychiatric diagnoses, and psychosocial and clinical factors were assessed and suicidality (suicidal ideation and or suicidal attempt) was the outcome variable. Logistic regression was used to calculate odds ratios adjusting for study site and sex at 95% confidence intervals.

Results

Caregivers reported a suicidality rate of 10.7% (CI 8–14.1) in the past one month with higher rates among urban female (12.4%, CI 8.6–17.7) than male (8.7%, CI 5.4–13.8) youth. Lifetime prevalence of attempted suicide was 2.3% (n = 9, CI 1.2–4.4) with the highest rates among urban female youth. Among children, caregivers reported a lifetime prevalence of attempted suicide of 1.5%. The self-reported rate of attempted suicide in the past month was 1.8% (n = 7, CI 0.8–3.7) with lifetime prevalence of 2.8% (n = 11, CI 1.6–5.0). The most common methods used during suicide attempts were cutting, taking overdose of HIV medications, use of organophosphates, hanging, stabbing and self-starvation. Clinical correlates of suicidality were low socioeconomic status (OR = 2.27, CI 1.06–4.87, p = 0.04), HIV felt stigma (OR = 2.10, CI 1.04–3.00, p = 0.02), and major depressive disorder (OR = 1.80, CI 0.48–2.10, p = 0.04). Attention-deficit/hyperactivity disorder was protective against suicidality (OR = 0.41, CI 0.18–0.92, p = 0.04).

Conclusion

The one-month prevalence of suicidality among CA-HIV was 10.7%.
Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells
Authors: Gao Jun , Gao Yao , Lin Shixin , Zou Xia , Zhu Yukai , Chen Xintong , Wan Hong , Zhu Hong
Published: October 2020

Objective

This study aimed to explore the effects of activating GABAB1 receptor by baclofen on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of ovarian cancer cells.

Results

One hundred μmol/L, 200 μmol/L and 300 μmol/L were selected as low, medium and high baclofen concentrations respectively. Cells were divided into four groups: Control, 100 μmol/L, 200 μmol/L and 300 μmol/L. Compared with the control group, the viability, colony formation, migration and invasion of SKOV3 cells were inhibited, and the apoptosis of SKOV3 cells were enhanced significantly at 200 μmol/L and 300 μmol/L baclofen. Moreover, they changed significantly with the increase of baclofen concentration. Compared with the control group, the expression of E-cadherin and GABAB1 increased and the N-cadherin expression decreased significantly in 200 μmol/L and 300 μmol/L groups. Higher concentration of baclofen induced higher expression of E-cadherin and lower expression of N-cadherin.

Conclusion

Baclofen inhibited the proliferation, cloning, migration, invasion and EMT of ovarian cancer cells by activating GABAB1 receptor. These results might contribute a lot to clarify the role and possible mechanism of GABAB1 receptor in ovarian cancer.
Psychosocial and pharmacologic interventions for methamphetamine addiction: protocol for a scoping review of the literature
Authors: Hamel C. , Corace K. , Hersi M. , Rice D. , Willows M. , Macpherson P. , Sproule B. , Flores-Aranda J. , Garber G. , Esmaeilisaraji L. , Skidmore B. , Porath A. , Ortiz Nunez R. , Hutton B.
Published: October 2020

Background

Methamphetamine use and harms are rising rapidly. Management of patients with methamphetamine use disorder (MUD) and problematic methamphetamine use (PMU) is challenging, with no clearly established best approach; both psychosocial and pharmacologic interventions have been described. Furthermore, given the diversity of individuals that use methamphetamines, there is a need to assess evidence for treatments for subgroups including youths; gay, bisexual, and other men who have sex with men; individuals with mental health comorbidities; and individuals in correction services. Establishing awareness of the messages regarding treatment from recent clinical practice guidelines (CPG) in the field is also of value.

The first study objective will be to establish a greater understanding of the methods, populations, and findings of controlled studies for psychosocial and pharmacologic treatments for MUD and PMU. Investigation of this information can help establish the potential for advanced syntheses of the evidence (such as network meta-analysis) to compare therapies for this condition and to identify gaps related to key populations where more primary research is needed. Summarizing the recommendations regarding treatment of MUD/PMU from recent CPGs and systematic reviews will be an important secondary objective.

Methods

A scoping review will be performed. Using the OVID platform, MEDLINE, Embase, PsycINFO, and relevant Cochrane databases from EBM Reviews will be searched (from databases’ inception onwards). Eligibility criteria will include individuals described as having MUD or PMU, with designs of interest including randomized trials, non-randomized trials, and controlled cohort studies with three or more months of follow-up; systematic reviews and CPGs will also be sought. Two reviewers (with support from automation tools) will independently screen all citations, full-text articles, and chart data. Different approaches to handling and summarizing the data will be implemented for each type of study design. Tables and graphics will be used to map evidence sources and identify evidence gaps.

Discussion

This research will enhance awareness of evidence addressing the effects of psychosocial and pharmacologic interventions for MUD/PMU overall and in sub-populations, both in terms of recent CPGs/reviews and primary studies; inspection of the latter will also help establish the feasibility of future syntheses to compare treatments, such as network meta-analysis.

Systematic review protocol registration

Open Science Framework (https://osf.io/9wy8p)
Nosocomial tuberculosis transmission from 2006 to 2018 in Beijing Chest Hospital, China
Authors: Xie Zhongyao , Zhou Ning , Chi Yuqing , Huang Guofang , Wang Jingping , Gao Hui , Xie Na , Ma Qianhui , Yang Nan , Duan Zhenlan , Nie Wenjuan , Sun Zhaogang , Chu Naihui
Published: October 2020

Introduction

Strong evidence is lacking to support effectiveness of currently implemented tuberculosis infection prevention control (TB-IPC) measures for preventing nosocomial tuberculosis (TB) transmission. This 13-year analysis is the longest follow-up investigation to date to identify risk factors underlying nosocomial TB transmission.

Methods

We monitored all staff of Beijing Chest Hospital each year from 2006 to 2018. Age, gender, duration, department, education, income, respirator, ultraviolet, and ventilation were chosen as variables. Univariate cox regression, correlation analysis, and multivariate cox regression were analyzed sequentially.

Results

Using multivariable cox regression analysis, variables of income, ultraviolet germicidal irradiation (UVGI), natural ventilation and mechanical ventilation conferred significant protective effects, with odds ratios of 0.499, 0.058, 0.003, and 0.015, respectively (P < 0.05). Medical N95 respirator conferred an excellent protective effect, with an associated TB infection rate of 0%. Notably, inadequately maintained mechanical ventilation systems were less protective than natural ventilation systems.

Conclusion

UVGI, adequate ventilation, and use of medical N95 respirator may be risk factors of nosocomial TB transmission.
Left atrial thrombus formation within a few days of hospitalization in semi-acute ischemic heart disease despite no atrial fibrillation and mitral stenosis: a case report
Authors: Okamura Keiko , Kodaka Mitsuharu , Ichikawa Junko , Ando Kazuyoshi , Komori Makiko
Published: October 2020

Background

Currently, the occurrence of left atrial thrombus despite the provision of heparinization within a few days of hospitalization without atrial fibrillation (AF) and mitral stenosis (MS) is rarely reported.

Case presentation

A 71-year-old woman presented with chest discomfort and dyspnea. Examination revealed ST elevation with sinus rhythm, congestive heart failure, and moderate mitral regurgitation (MR) by transthoracic echocardiography (TTE). Diuretics, a coronary vasodilator, and unfractionated heparin (15,000 units/day) were administered. Four days after hospitalization, her C-reactive protein level had increased; therefore, TTE was repeated, revealing a thrombus in the left atrial appendage, which was probably affected by heparin resistance because of low antithrombin (49%). On day 5, the patient underwent emergency removal of the thrombus, mitral valve replacement, and coronary artery bypass.

Conclusion

Patients can exhibit low left ventricular contractility, even sinus rhythm without MS. Thus, TTE and subsequent coagulation tests including antithrombin must be performed to prevent thrombus.
Weighted gene co-expression network analysis revealed key biomarkers associated with the diagnosis of hypertrophic cardiomyopathy
Authors: Li Xin , Wang Chenxin , Zhang Xiaoqing , Liu Jiali , Wang Yu , Li Chunpu , Guo Dongmei
Published: October 2020

Objective

To reveal the molecular mechanism underlying the pathogenesis of HCM and find new effective therapeutic strategies using a systematic biological approach.

Methods

The WGCNA algorithm was applied to building the co-expression network of HCM samples. A sample cluster analysis was performed using the hclust tool and a co-expression module was constructed. The WGCNA algorithm was used to study the interactive connection between co-expression modules and draw a heat map to show the strength of interactions between modules. The genetic information of the respective modules was mapped to the associated GO terms and KEGG pathways, and the Hub Genes with the highest connectivity in each module were identified. The Wilcoxon test was used to verify the expression level of hub genes between HCM and normal samples, and the “pROC” R package was used to verify the possibility of hub genes as biomarkers. Finally, the potential functions of hub genes were analyzed by GSEA software.

Results

Seven co-expression modules were constructed using sample clustering analysis. GO and KEGG enrichment analysis judged that the turquoise module is an important module. The hub genes of each module are RPL35A for module Black, FH for module Blue, PREI3 for module Brown, CREB1 for module Green, LOC641848 for module Pink, MYH7 for module Turquoise and MYL6 for module Yellow. The results of the differential expression analysis indicate that MYH7 and FH are considered true hub genes. In addition, the ROC curves revealed their high diagnostic value as biomarkers for HCM. Finally, in the results of the GSEA analysis, MYH7 and FH highly expressed genes were enriched with the “proteasome” and a “PPAR signaling pathway,” respectively.

Conclusions

The MYH7 and FH genes may be the true hub genes of HCM. Their respective enriched pathways, namely the “proteasome” and the “PPAR signaling pathway,” may play an important role in the development of HCM.
E-cigarette, or vaping, product use-associated lung injury: a review
Authors: Belok Samuel H. , Parikh Raj , Bernardo John , Kathuria Hasmeena
Published: October 2020

Background

E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) is a disease entity related to the use of battery-operated or superheating devices that create an aerosolized form of nicotine and tetrahydrocannabinol (THC) and/or other substances for inhalation.

Methods

We performed a literature review to document epidemiology, pathogenesis and risk factors, diagnosis, clinical presentation, evaluation and management of EVALI.

Results

In the summer of 2019, an outbreak of EVALI cases brought this disease entity into the national spotlight. Since being recognized as a serious pulmonary disease with public health implications, more than 2600 cases have been reported to CDC with 68 deaths as of February 2020. The pathophysiology of EVALI remains unknown. Substances such as Vitamin E acetate have been implicated as a possible causes of lung injury. The CDC has established case definitions of “confirmed EVALI” cases to help guide identification of the disease and assist in surveillance. While clinical judgement by healthcare providers is imperative in the identification of EVALI cases, the heterogeneous presentations of EVALI make this difficult as well. Ultimately most investigative studies should be aimed at ruling out other disease processes that can present similarly. Treatment is centered around removing the offending substance and providing supportive care.

Conclusions

EVALI is a serious pulmonary disease with public health implications. Diagnosis requires a high degree of suspicion to diagnose and exclusion of other possible causes of lung disease. It may be beneficial to involve a pulmonary specialist early in the management of this disease which is generally supportive care.
Phenylpropanoid metabolism and pigmentation show divergent patterns between brown color and green color cottons as revealed by metabolic and gene expression analyses
Authors: LI Zhonghua , SU Qian , XU Mingqi , YOU Jiaqi , KHAN Anam Qadir , LI Junyi , ZHANG Xianlong , TU Lili , YOU Chunyuan
Published: October 2020

Background

Naturally-colored cotton has become increasingly popular because of their natural properties of coloration, UV protection, flame retardant, antibacterial activity and mildew resistance. But poor fiber quality and limited color choices are two key issues that have restricted the cultivation of naturally-colored cotton. To identify the possible pathways participating in fiber pigmentation in naturally-colored cottons, five colored cotton accessions in three different color types (with green, brown and white fiber) were chosen for a comprehensive analysis of phenylpropanoid metabolism during fiber development.

Results

The expression levels of flavonoid biosynthesis pathway genes in brown cotton fibers were significantly higher than those in white and green cotton fibers. Total flavonoids and proanthocyanidin were higher in brown cotton fibers relative to those in white and green cotton fibers, which suggested that the flavonoid biosynthesis pathway might not participate in the pigmentation of green cotton fibers. Further expression analysis indicated that the genes encoding enzymes for the synthesis of caffeic acid derivatives, lignin and lignan were activated in the developing fibers of the green cotton at 10 and 15 days post-anthesis.

Conclusions

Our results strengthen the understanding of phenylpropanoid metabolism and pigmentation in green and brown cotton fibers, and may improve the breeding of naturally-colored cottons.
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency
Authors: Merakou Christina , Fylaktou Irene , Sertedaki Amalia , Dracopoulou Maria , Voutetakis Antonis , Efthymiadou Alexandra , Christoforidis Athanasios , Dacou-Voutetakis Catherine , Chrysis Dionisios , Kanaka-Gantenbein Christina
Published: October 2020

Context

Isolated congenital hypoaldosteronism presents in early infancy with symptoms including vomiting, severe dehydration, salt wasting, and failure to thrive. The main causes of this rare autosomal recessive disorder is pathogenic variants of the CYP11B2 gene leading to aldosterone synthase deficiency.

Objective

To investigate the presence of CYP11B2 pathogenic variants in a cohort of patients with a clinical, biochemical, and hormonal profile suggestive of aldosterone synthase deficiency.

Design

Clinical and molecular study.

Setting

Tertiary academic Children’s Hospital, Center for Rare Pediatric Endocrine Diseases.

Patients and Methods

Sixty-two patients (56 unrelated patients and 6 siblings), with hypoaldosteronism and their parents, underwent CYP11B2 gene sequencing after its selective amplification against the highly homologous CYP11B1 gene. In silico analysis of the identified novel variants was carried out to evaluate protein stability and potential pathogenicity.

Results

CYP11B2 gene sequencing revealed that 62 patients carried a total of 12 different pathogenic CYP11B2 gene variants, 6 of which are novel. Importantly, 96% of the 56 patients carried the previously reported p.T185I variant either in homozygosity or in compound heterozygosity with another variant. The 6 novel variants detected were: p.M1I, p.V129M, p.R141Q, p.A165T, p.R448C, and the donor splice site variant of intron 8, c.1398 + 1G > A.

Conclusion

Molecular diagnosis was achieved in 62 patients with aldosterone synthase deficiency, the largest cohort thus far reported. Six novel genetic variants were identified as possibly pathogenic, extending the spectrum of reported molecular defects of the CYP11B2 gene.
Effect of Exercise Intensity on Exogenous Glucose Requirements to Maintain Stable Glycemia At High Insulin Levels in Type 1 Diabetes
Authors: Shetty Vinutha B , Fournier Paul A , Paramalingam Nirubasini , Soon Wayne , Roby Heather C , Jones Timothy W , Davis Elizabeth A
Published: October 2020

Context

Under basal insulin levels, there is an inverted U relationship between exercise intensity and exogenous glucose requirements to maintain stable blood glucose levels in type 1 diabetes (T1D), with no glucose required for intense exercise (80% V̇O2 peak), implying that high-intensity exercise is not conducive to hypoglycemia.

Objective

This work aimed to test the hypothesis that a similar inverted U relationship exists under hyperinsulinemic conditions, with high-intensity aerobic exercise not being conducive to hypoglycemia.

Methods

Nine young adults with T1D (mean ± SD age, 22.6 ± 4.7 years; glycated hemoglobin, 61 ± 14 mmol/mol; body mass index, 24.0 ± 3.3 kg/m2, V̇O2 peak, 36.6 ± 8.0 mL·kg–1 min–1) underwent a hyperinsulinemic-euglycemic clamp to maintain stable glycemia (5-6 mmol·L−1), and exercised for 40 minutes at 4 intensities (35%, 50%, 65%, and 80% V̇O2peak) on separate days following a randomized counterbalanced study design.

Main Outcome Measures

Glucose infusion rates (GIR) and glucoregulatory hormones levels were measured.

Results

The GIR (± SEM) to maintain euglycemia was 4.4 ± 0.4 mg·kg–1 min–1 prior to exercise, and increased significantly by 1.8 ± 0.4, 3.0 ± 0.4, 4.2 ± 0.7, and 3.5 ± 0.7 mg·kg–1 min–1 during exercise at 35%, 50%, 65%, and 80% V̇O2 peak, respectively, with no significant differences between the 2 highest exercise intensities (P > .05), despite differences in catecholamine levels (P < .05). During the 2-hour period after exercise at 65% and 80% V̇O2 peak, GIRs did not differ from those during exercise (P > .05).

Conclusions

Under hyperinsulinemic conditions, the exogenous glucose requirements to maintain stable glycemia during and after exercise increase with exercise intensity then plateau with exercise performed at above moderate intensity ( > 65% V̇O2 peak). High-intensity exercise confers no protection against hypoglycemia.
Professionalismi, õppimise ja identiteedi kontseptsioonide sidumine
Authors: Ruijters Manon C. P. , Simons P. Robert-Jan
Published: October 2020

Selles kontseptuaalses artiklis püüame ühendada mõned oma varasematest käsitustest uueks sidusaks õppija identiteedi mudeliks. Artikli esimeses osas esitame ülevaate teadusuuringutest ja teooriatest, mis käsitlevad professionaalset ja töökohal õppimist. Teises osas vaatleme töötamist nn õppe maastikul. See on metafoor, mida kasutame organisatsioonilise õppimise kirjeldamiseks. Kolmandas osas käsitleme õppimiseelistusi: kirjeldame viit töökohal õppimise viisi. Neljandas osas tutvustame õppiva professionaali kontseptsiooni. Viiendas osas anname ülevaate teadusuuringutest ja teooriatest, mis käsitlevad professionaalset identiteeti, mille lahutamatuteks osadeks on see, kes sa oled (inimesena), millist tööd (elukutse) ja kus sa seda teed (keskkond). Arutelu osas püüame selgitada, kuidas saab erinevaid mudeleid ühendada, diferentseerida ja lõimida. Kõikide käsitluste puhul lähtume professionaalsest identiteedist. Lõimitud kontseptuaalses küsimustikus võtame kogu teema kokku, pakume välja õppija identiteedi uue kontseptsiooni ja näitame, milliseid tulemusi annab professionaalse õppimiskultuuri soodustamine.

 Full text
Eesti keele ja matemaatika õppevara valiku põhimõtted ja eesmärgid lasteaia- ja klassiõpetajate hinnangul
Authors: Taimalu Merle , Uibu Krista , Leola Heily
Published: October 2020

Kvaliteetne õppevara on abivahend, mis on õpetajale toeks laste arengu eesmärgipärasel suunamisel. Uurimuse eesmärk oli välja selgitada, millisena hindavad Eesti lasteaia- ja klassiõpetajad oma võimalusi otsustada eesti keele ja matemaatika õppevara valiku üle, millistest põhimõtetest nad lähtuvad ja milliste eesmärkide täitmist õppevara puhul oluliseks peavad. Erinevuste väljaselgitamiseks lasteaia- ja klassiõpetajate hinnangute vahel küsitleti 64 lasteaiaõpetajat ja 47 klassiõpetajat, kasutades valikvastuste ja avatud küsimustega ankeeti. Õppevara valiku põhimõtteid analüüsides eristus neli peakategooriat: vastavus õppekavale, sisu ja ülesannete mitmekesisus, sisu ja ülesannete selgus ja arusaadavus, välised tegurid. Õppevara eesmärkidest tõid õpetajad kõige sagedamini välja, et heal tasemel õppevara peaks toetama laste kognitiivsete oskuste kujundamist. Samuti selgus, et võrreldes klassiõpetajatega saavad lasteaiaõpetajad rohkem ise otsustada, millist õppevara eesti keele või matemaatika õpetamisel kasutada. Teadvustades, millistest põhimõtetest õppevara valikul lähtuda ja milliseid eesmärke heal tasemel õppevara täidab, saab õpetaja teha otsuseid, mis toetavad mitmekülgselt lapse arengut.

 Summary
Otsides "müstilist miskit": millest koosneb kooli maine?
Authors: Tikerperi Mari-Liis
Published: October 2020

Kooli maine on leidnud Eesti üldhariduse kontekstis käsitlemist kui koondmõiste, mis määrab kooli positsiooni abstraktses võrdluses teistega. Teoreetilised lähenemised näevad maine seoseid organisatsiooni identiteediga ja mainekujundust osana organisatsiooni juhtimisest. Muutunud ühiskondlikud nõudmised ja nüüdisaja meediaruum on koolijuhtimisse toonud muu hulgas vajaduse olla nähtav ning kujundada oma tegevust huvirühmade ootuste järgi. Kvalitatiivse uuringu eesmärk oli välja selgitada, millised indikaatorid loovad koolijuhtide (N = 19) hinnangul arusaama kooli mainest ning millised on koolide kogemused mainekujundusega. Olulise tulemusena võib näha, et kooli maine ei ole konstantne väärtus, vaid sõltub üldiselt pikemast ajalisest faktorist ja maine tajuja positsioonist huvirühmade koosseisus. Maine teadlikumaks kujundamiseks pole aga alati piisavalt vahendeid ega oskusi ning osa mainekujunduslikest katsumustest on seotud hoopis kooliväliste teguritega.

 Summary
Väärtuskasvatust toetavad tegevused ja nende enesehinnanguline tulemuslikkus Eesti üldhariduskoolide näitel
Authors: Parder Mari-Liisa , Hirsnik Helen
Published: October 2020

Siinse uurimuse eesmärk on analüüsida väärtuskasvatust toetavaid tegevusi ja nende tulemuslikkuse hindamist Eesti üldhariduskoolides. Uurime, kuivõrd toovad Eesti üldhariduskoolid refleksiooni kaudu välja väärtusi toetavaid tegevusi ning analüüsivad deklareeritud ja tegevustes rakendatavate väärtuste kooskõla. Vaatluse all on tegevused, mida koolid seostavad väärtuskasvatuse toetamisega, ning see, kas ja milliste meetoditega analüüsivad koolid väärtuskasvatust toetavate tegevuste tulemuslikkust. Analüüsi aluseks on üldhariduskoolide koostatud eneseanalüüsid, mis on esitatud Tartu Ülikooli eetikakeskuse tunnustusprogrammi ja mis sisaldavad väärtusarenduse analüüsi neljas valdkonnas. Valimisse kuulub 39 eneseanalüüsi aastatest 2010; 2016 ja 2019, mida analüüsiti kvalitatiivse sisuanalüüsi abil. Siinse uurimuse põhjal saab öelda, et Eesti koolides on levinud integreeriv eetiline kasvatus.

 Summary
A Scholar Poet from the Neighbouring Land
Authors: Chettiarthodi Rajendran
Published: October 2020

A Scholar Poet from the Neighbouring Land: Uddaṇḍa Śāstrin’s Perceptions of Kerala

The present paper proposes to investigate the perceptions of Kerala in the works of Uddaṇḍa Śāstrin, a remarkable scholar, who came in search of patronage to the court of Mānavikrama, the Zamorin of Calicut of the 15th century A.D, from Lāṭapura, a famous Brahmin centre in Toṇḍamaṇḍala, in Chengalpattu, in the present Tamil Nadu. Often stereotyped as a haughty outsider looking down upon his contemporaries with contempt, Uddaṇḍa was actually a sharp-witted scholar, who readily appreciated the scholarship of his adopted land, even while mincing no words when he encountered mediocrity. His message poem Kokilasandeśa and his play Mallikāmāruta, as well as many stray verses still current in Kerala, apart from being a veritable treasure of information as far as medieval Kerala is concerned, are of great cultural significance as they register the perceptions of a gifted scholar poet from the neighbouring land. Unfortunately, in popular imagination, he is projected as a haughty outsider outsmarting indigenous scholarship, but ultimately defeated by a native prodigy in the form of Kākkaśśeri Bhaṭṭatiri. This paper aims at retrieving Uddaṇḍa’s valuable and often unbiased insights of Kerala, which are often overlooked in popular perceptions of him. As a sensitive author who recorded his impressions on crossing the geographical boundaries of his native land to reach Kerala, his firsthand accounts of great cities, centres of learning, famous temples, food habits and festivals, such as Ōṇaṃ of Kerala, that can be found in his works are really worth probing.
The Female Voice and the Crossing of the Boundaries of Scholarship
Authors: Anandakichenin Suganya
Published: October 2020

The Female Voice and the Crossing of the Boundaries of Scholarship: A Note on the Rahasyam of the Lady from Tirukkōḷūr, with a Complete, Annotated Translation

The Śrīvaiṣṇavas are prolific writers, who masterfully used multiple languages for composing works in a range of genres, from commentaries to esoterical works, from devotional poetry to hagiography. But while this community, roughly half of which consists of women, claims equality with a difference for women—which includes the right to liberation at death and to religious, albeit non-Vedic, learning—it hardly seems to have encouraged them to emulate the male authors and produce works of any kind. Despite this attitude, a few female voices, sometimes muffled as they can be, are heard across the centuries. One such voice belongs to Tirukkōḷūr peṇpiḷḷai (“the woman from Tirukkōḷūr,” 12th c.?), who allegedly spoke words betraying her scholarly knowledge, and that, too, to the great Rāmānuja himself. Who this woman—who ventured into the jealously-guarded male domain of scholarship—was, and what her ‘composition’ deals with are the topics of this brief essay.
Exit God: Border Crossings in Jīrṇoddhāra Procedure
Authors: Mills Libbie
Published: October 2020

Exit God: Border Crossings in Jīrṇoddhāra Procedure

Jīrṇoddhāra, the disposal and replacement of an old idol or temple, necessitates the temporary departure of the deity from that place. The ritual for this departure will be followed as it is reported in two texts: the Piṅgalāmata and the Tantrasamuccaya. The Piṅgalāmata is useful in understanding the process of jīrṇoddhāra: the text defines the process, explains the need for it, rationalises the ritual procedure, and gives a brief account of it. The description in the Tantrasamuccaya gives finer detail on how the procedure should be carried out. Unlike other records of the subject, that of the Tantrasamuccaya does not glide over the most important moments of transition for the deity, but stops to consider them in depth, giving attention to his displacement in terms of saṅkocana (contraction), niṣkrāmaṇa (expulsion), and sūtracchidā (the severing of the cord). While this pair of texts offers the material in contrasting forms, the two sets of teaching are found to be congruent one with the other, making them companion pieces that give us a good view into what it means to invite the deity to leave. We find that in order for the deity to cross concentric borders to leave his base, the human ritual officiant must make a crossing too, and, indeed, the borders themselves will be moved around.
Extending the Scope of Health Visiting and School Nursing Practice Within a 0–19 Service
Authors: Peckover Sue , Shearn Katie , Wood David , Frankland Sharon , Day Patricia
Published: October 2020

In 2018, an employing organisation in the north of England introduced an initiative for health visitors and school nurses (SCPHN) to work in the other field of practice. The aim of this study was to explore SCPHN professionals’ and managers’ views about the introduction, benefits and challenges of extended SCPHN practice. Semi-structured interviews were undertaken with health visitors, school nurses, practice teachers, mentors and managers undertaking or supporting this initiative (n=18) and one focus group with eight SCPHNs working in the 0–19 service. These were audio-recorded, transcribed and thematically analysed. Workplace learning was challenging. Support from colleagues, mentors and practice teachers was crucial. Additional skills and knowledge were valued. SCPHNs gained confidence in working with children and families across the 0–19 age range. Additional skills enabled SCPHNs to deliver a more streamlined service to families with children aged 0–19 but concerns about workforce capacity and changing professional roles remain.
Effects of Different Agitator Blades on the Production Process of Biopolymer WL Gum by Sphingomonas sp. WG
Authors: Li Hui , Zhou Wanlong , Wang Jiqian , Zhu Hu
Published: October 2020

The effects of three agitators with different blade shapes, including the commonly-used six-flat-blade disc turbine, six-curved-blade disc turbine, and six-arrow-blade disc turbine on the production of biopolymer WL gum by Sphingomonas sp. WG was investigated in detail. The experiments were performed at the agitation speeds ranging from 100 to 500 r/min. The results showed that the moderate agitation speed was conducive to cell growth and WL gum production when using the agitators with curved-blade and arrow-blade. The maximal cell growth and WL gum were obtained at 300 r/min and 400 r/min, respectively. The six-arrow-blade disc turbine yielded the highest cell growth (11.74 g/L), WL gum production (40.89 g/L), and broth viscosity (91.62 Pa•s) among the three agitators. A comparison of the mixing characteristics showed that the power consumption of a six-arrow-blade disc turbine was the lowest. Overall, the six-arrow-blade disc turbine is suitable for WL gum fermentation with low energy consumption and high WL gum yield and viscosity. This work provided valuable information for large-scale industrial production of biopolymer WL gum.
Aplicativo web para caracterizar a qualidade da água
Authors: Almeida Rosa Alencar Santana de , Almeida Caio Sacramento de Britto , Souza Lucas Dos Santos , Santos Débora Abdalla
Published: October 2020

Diante do atual cenário dos recursos hídricos, os índices de qualidade de água (IQA) são recursos apropriados para comunicar, ao público em geral, a qualidade da água de mananciais superficiais e subterrâneos. Os índices são formulações matemáticas agregadoras de parâmetros que resumem as informações em um número, permitindo uma leitura fácil ao público não técnico. Ao longo dos anos foram desenvolvidas várias expressões de IQAs, muitas com rigidez na escolha dos parâmetros indicadores de qualidade e/ou com limitações na região geográfica de aplicação. Foi elaborado um Índice de Qualidade da Água (e-IQUAS) que permite a escolha de parâmetros de maneira flexível, sem limite no número de variáveis e pode ser aplicado aos múltiplos usos da água. Para permitir seu uso irrestrito à sociedade, foram desenvolvidos, com ferramentas de software livre: um aplicativo web, amigável e fácil de usar, e uma rede social para disseminação de informações sobre o tema. O aplicativo foi testado, verificado e está disponível na rede mundial de computadores. O trabalho contribui, portanto, para disseminar o uso do índice de qualidade de água e-IQUAS, de fácil aplicação e adaptado a qualquer região ou compartimento hídrico.
Analisis Usabilitas pada Permainan 'The Zoo' Berbasis Kinect
Authors: Putra Feby Adhi , Satoto Kodrat Iman , Martono Kurniawan Teguh
Published: October 2020

Interaksi manusia dan komputer merupakan komunikasi dua arah antara pengguna dengan sistem komputer yang saling mendukung untuk mencapai suatu tujuan tertentu. Kinect menghadirkan pengalaman interaksi baru dalam dunia permainan karena pemain menggunakan anggota tubuh dalam mengoperasikan permainan. Permainan ‘The Zoo’ adalah permainan edukasi berbasis Kinect yang memperkenalkan beberapa kosakata hewan dalam Bahasa Inggris.Usabilitas suatu produk merupakan kunci agar produk tersebut selalu digunakan. Untuk memudahkan anak dalam menggunakan permainan ‘The Zoo’, digunakan perancangan antarmuka dengan metode ragam dialog manipulasi langsung.Metode penelitian dilakukan dengan metode kuesioner yang kemudian dari hasil kuesioner tersebut diolah menggunakan skala Likert sehingga dapat disimpulkan antarmuka permainan ‘The Zoo’ telah sesuai dengan Teori Jakob Nielsen. Berdasarkan hasil penelitian, didapatkan hasil pengujian usabilitas permainan ‘The Zoo’ yaitu aspek Learnability sebesar 78.7%, aspek Efficiency sebesar 77.3%, aspek Memorability sebesar 89.5%, aspek Errors sebesar 80.7% dan aspek Satisfaction sebesar 80%.
PERANCANGAN PERMAINAN MENGASAH DAYA INGAT “MEMORY TRAINING” MENGGUNAKAN GREENFOOT
Authors: Kurniasari Yessy , Isnanto R. Rizal , Nurhayati Oky Dwi
Published: October 2020

Selama ini permainan anak-anak dilakukan secara tradisional, tetapi permainan tradisional ini memiliki kekurangan yaitu membutuhkan waktu khusus, membutuhkan tempat yang luas, dimainkan di luar rumah, serta dapat menyebabkan cidera dan kelelahan. Seiring dengan kemajuan teknologi yang pesat, permainan modern semakin diminati oleh anak-anak, terutama permainan yang berbasis komputer. Selain dapat menghilangkan kejenuhan, permainan juga merupakan salah satu cara efektif untuk mengasah daya ingat. Oleh karena itu, perlu dilakukan penelitian untuk mengembangkan permainan mengasah daya ingat “Memory Training” untuk anak-anak yang berusia 7 sampai 12 tahun. Perangkat lunak yang digunakan untuk membuat permainan ini yaitu Greenfoot, yang berbasis bahasa pemrograman Java dengan konsep pemrograman berorientasi objek. Tahap perancangan dimulai dengan merancang konsep, isi, naskah, dan grafik permainan. Tahap implementasi dilakukan dengan membangun dan mengembangkan permainan sesuai dengan rancangan yang sudah dibuat, yaitu meliputi implementasi program dan grafik. Tahap pengujian dilakukan dengan metode black-box serta dilakukan uji coba secara langsung kepada 20 anak.Hasil pengujian menunjukkan bahwa permainan ini dapat berjalan dengan baik pada sistem operasi Windows XP dan Windows 7. Tombol-tombol dan fungsi-fungsi pada permainan juga dapat berfungsi dengan baik dan sesuai dengan fungsionalitasnya masing-masing. Berdasarkan penilaian yang diberikan oleh 20 anak, permainan “Memory Training” ini dinilai menarik, mudah dipahami dan dimainkan, mampu mengasah daya ingat, serta tampilan permainannya bagus, sehingga menarik perhatian anak-anak untuk memainkan permainan ini kembali. Hal ini terlihat pada semua aspek penilaian, yang mendapatkan persentase lebih dari 90%.
Pengembangan Aplikasi Berbasis Web untuk Menampilkan Absensi dan Nilai Akhir Peserta Didik (Studi Kasus di SMP Negeri 32 Semarang)
Authors: Mountaines Patricia Evericho , Satoto Kodrat Iman , Kridalukmana Rinta
Published: October 2020

Aplikasi berbasis web telah banyak digunakan sebagai media penyampai informasi disektor pendidikan. Namun, SMP Negeri 32 Semarang belum mulai memanfaatkan teknologi ini.Hal ini dipandang kurang efektif dan efisien, terutama oleh peserta didik. SMP Negeri 32Semarang kini membutuhkan aplikasi berbasis web yang mampu menampung informasi tentangsekolah sekaligus menampilkan data absensi dan nilai akhir peserta didik.Agar dalam implementasi aplikasi tidak memakan biaya mahal, maka aplikasidikembangkan dengan menggunakan perangkat lunak open source. Untuk bahasa pemogramanmenggunakan PHP sedangkan untuk basis data menggunakan MySQL, yang sudah terangkumdalam satu paket aplikasi XAMPP. Metode pengembangan aplikasi yang digunakan adalahmetode SDLC (Software Development Life Cycle) model Waterfall.Dari hasil pengujian yang telah dilakukan, diketahui bahwa hasil keluaran yangditunjukkan selama proses pengujian sesuai dengan rancangan sistem. Maka dapat disimpulkanbahwa Aplikasi Berbasis Web untuk Menampilkan Absensi dan Nilai Akhir Peserta Didik ini telahberhasil dikembangkan dan dapat berfungsi dengan baik.
Perancangan Aplikasi Ujian Online Jurusan Sistem Komputer Universitas Diponegoro
Authors: Meinawati Tristy , Satoto Kodrat Iman , Nurhayati Oky Dwi
Published: October 2020

E-service adalah istilah untuk suatu layanan elektronik yang memanfaatkan teknologi informasi dan komunikasi untuk mempermudah penggunanya untuk melakukan suatu aktifitas tertentu. Salah satu manfaat dari e-service adalah akses yang lebih luas. Salah satu aplikasi dari e-service adalah aplikasi ujian online. Aplikasi ujian online adalah aplikasi yang bertujuan mempermudah melakukan ujian, yaitu  secara online. Aplikasi ujian online difokuskan  untuk ujian penerimaan mahasiswa baru pada Jurusan Sistem Komputer karena Jurusan Sistem Komputer tersebut berkaitan erat dengan teknologi informasi sehingga sewajarnya jika penerimaan mahasiswa baru dilaksanakan secara online.Dengan menggunakan sebuah sistem basis data, ujian online ini diharapkan mempermudah sistem ujian dalam menampilkan soal-soal maupun penilaian sehingga mempermudah user untuk menggunakannya serta bagi administrator untuk mengelola soal. Dalam e-service yang dibuat kali ini adalah menggunakan PHP sebagai program aplikasi dan MySQL sebagai server basis data yang sudah terangkum dalam satu aplikasi XAMPP.Dengan adanya aplikasi ini diharapkan menambah minat masyarakat terhadap Jurusan Sistem Komputer Universitas Diponegoro, dan juga mempermudah pengguna untuk melakukan ujian secara online dan tidak perlu menggunakan alat tulis untuk melakukan pengerjaan.
Perancangan Aplikasi Toko Online "XO-Licious" Berbasis Mobile Web pada Sistem Operasi Android
Authors: Arviningrum Alifvia , Satoto Kodrat Iman , Kridalukmana Rinta
Published: October 2020

XO-Licious merupakan sebuah toko online  yang  bergerak dalam bidang penjualan original CD, official  maupun unofficial goods para penyanyi di Asia. Sasaran penjualan dari toko online ini adalah kalangan muda. Agar tidak kalah bersaing dengan banyaknya toko online yang sekarang ada, maka XO-Licious membutuhkan suatu terobosan yang dapat mempermudah pembeli untuk melakukan transaksi maupun hanya untuk mendapatkan update terbaru.Mobile commerce atau seringkali disebut dengan m-commerce adalah pengembangan  sistem perdagangan elektronik (e-commerce) dengan menggunakan peralatan portabel/mobile seperti telepon genggam, Smart Phone, PDA, atau Notebook.  Aplikasi mobile commerce yang dibangun adalah aplikasi mobile yang dapat berjalan pada sistem operasi android. Karena saat ini android telah menguasai pasar smartphone dan merupakan sistem operasi open source yang mudah untuk dikembangkan. Framework yang digunakan dalam pembuatan m-commerce ini adalah jQuery Mobile dan PhoneGap. Framework – framework tersebut tersebut dipilih karena memiliki banyak fitur yang menarik seperti, tampilan jQuery mobile dapat menyesuaikan layar dari perangkat bergerak. Sedangkan PhoneGap merupakan sebuah framework opensource yang digunakan untuk membuat aplikasi cross-platform mobile hanya dengan menggunakan bahasa pemrograman HTML , JavaScript dan CSSMobile commerce yang berbasis mobile web akan sangat cocok untuk XO-Liciou. Aplikasi mobile commerce ini dapat mempermudah pelanggan/pembeli untuk memesan barang dari XO-Licious dimanapun dan kapanpun melalui smartphone atau  tablet yang telah menjadi gaya hidup remaja saat ini.
Sistem Informasi Inventory dan Peminjaman Barang pada Laboratorium Program Studi Sistem Komputer
Authors: Rajendra Rifky , Satoto Kodrat Iman , Kridalukmana Rinta
Published: October 2020

Information technology development today resulted in the growing number of internet users. Easy access of the internet makes it as a media presentation of data to both individuals and institutions. It is similar with Computer System major that has taken advantage of the Internet to provide a variety of information to both academic and community service in the field of information technology. But it is still using manual method to organize and inventorydata associated with inventory and borrowing system of lab in a site. One way to ease the data organization is to design an information system that can record and organize all the data held by the Computer System.Design and Implementation phase begins with system requirement analysis. Its objection is to get a proper system specification. In design phase, Data Flow Diagram is used to represent data in a logic way. The result from design phase then implements with PHP programming language, associated with Database Management System MySQL, and Javascript to generate a dynamic web-based information system.System Information inventory and Loan goods on the laboratory computer system, has two categories of access rights, there are super admin and admin (operator), where the super admin have all permissions and the lending system inventory information communications system laboratory, while the operator is further divided into three parts ie (embedded, networking, and software engineer) where each lab has one operator and one other can notaccess that does not belong to its access. The test results and Loan Information Systems Inventory Computer Systems Laboratory, showed that all the features of the application can work well as Super Admin can see the entire menu of each Lab and can make the process of printing from any lab reports, for each lab operator can to process the data change, the process of borrowing items and returns. Using the Entity Relationship Diagram modeling system. The information systems have as many as four users on the system, which are super admin, operator Lab embedded, networking lab operator, operator Lab Engineer software.