bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of a New Wearable Mobile Device for the Automated Detection of Resting Tremor in Parkinson’s Disease and Essential Tremor
Authors: Vescio Basilio , Nisticò Rita , Augimeri Antonio , Quattrone Andrea , Crasà Marianna , Quattrone Aldo
Published: January 2021

Involuntary tremor at rest is observed in patients with Parkinson’s disease (PD) or essential tremor (ET). Electromyography (EMG) studies have shown that phase displacement between antagonistic muscles at prevalent tremor frequency can accurately differentiate resting tremor in PD from that detected in ET. Currently, phase evaluation is qualitative in most cases. The aim of this study is to develop and validate a new mobile tool for the automated and quantitative characterization of phase displacement (resting tremor pattern) in ambulatory clinical settings. A new low-cost, wearable mobile device, called µEMG, is described, based on low-end instrumentation amplifiers and simple digital signal processing (DSP) capabilities. Measurements of resting tremor characteristics from this new device were compared with standard EMG. A good level of agreement was found in a sample of 21 subjects (14 PD patients with alternating resting tremor pattern and 7 ET patients with synchronous resting tremor pattern). Our results demonstrate that tremor analysis using µEMG is easy to perform and it can be used in routine clinical practice for the automated quantification of resting tremor patterns. Moreover, the measurement process is handy and operator-independent.
Whole-Genome Sequencing for Investigating a Health Care-Associated Outbreak of Carbapenem-Resistant Acinetobacter baumannii
Authors: Hwang Sang Mee , Cho Hee Won , Kim Tae Yeul , Park Jeong Su , Jung Jongtak , Song Kyoung-Ho , Lee Hyunju , Kim Eu Suk , Kim Hong Bin , Park Kyoung Un
Published: January 2021

Carbapenem-resistant Acinetobacter baumannii (CRAB) outbreaks in hospital settings challenge the treatment of patients and infection control. Understanding the relatedness of clinical isolates is important in distinguishing outbreak isolates from sporadic cases. This study investigated 11 CRAB isolates from a hospital outbreak by whole-genome sequencing (WGS), utilizing various bioinformatics tools for outbreak analysis. The results of multilocus sequence typing (MLST), single nucleotide polymorphism (SNP) analysis, and phylogenetic tree analysis by WGS through web-based tools were compared, and repetitive element polymerase chain reaction (rep-PCR) typing was performed. Through the WGS of 11 A. baumannii isolates, three clonal lineages were identified from the outbreak. The coexistence of blaOXA-23, blaOXA-66, blaADC-25, and armA with additional aminoglycoside-inactivating enzymes, predicted to confer multidrug resistance, was identified in all isolates. The MLST Oxford scheme identified three types (ST191, ST369, and ST451), and, through whole-genome MLST and whole-genome SNP analyses, different clones were found to exist within the MLST types. wgSNP showed the highest discriminatory power with the lowest similarities among the isolates. Using the various bioinformatics tools for WGS, CRAB outbreak analysis was applicable and identified three discrete clusters differentiating the separate epidemiologic relationships among the isolates.
How Secure Are Two-Way Ping-Pong and LM05 QKD Protocols under a Man-in-the-Middle Attack?
Authors: Pavičić Mladen
Published: January 2021

We consider a man-in-the-middle attack on two-way quantum key distribution ping-pong and LM05 protocols in which an eavesdropper copies all messages in the message mode, while being undetectable in the mode. Under the attack there is therefore no disturbance in the message mode and the mutual information between the sender and the receiver is always constant and equal to one and messages copied by the eavesdropper are always genuine. An attack can only be detected in the control mode but the level of detection at which the protocol should be aborted is not defined. We examine steps of the protocol to evaluate its security and find that the protocol should be redesigned. We also compare it with the security of a one-way asymmetric BB84-like protocol in which one basis serves as the message mode and the other as the control mode but which does have the level of detection at which the protocol should be aborted defined.
Device-Free Crowd Counting Using Multi-Link Wi-Fi CSI Descriptors in Doppler Spectrum
Authors: Brena Ramon F. , Escudero Edgar , Vargas-Rosales Cesar , Galvan-Tejada Carlos E. , Munoz David
Published: January 2021

Measuring the quantity of people in a given space has many applications, ranging from marketing to safety. A family of novel approaches to measuring crowd size relies on inexpensive Wi-Fi equipment, taking advantage of the fact that Wi-Fi signals get distorted by people’s presence, so by identifying these distortion patterns, we can estimate the number of people in such a given space. In this work, we refine methods that leverage Channel State Information (CSI), which is used to train a classifier that estimates the number of people placed between a Wi-Fi transmitter and a receiver, and we show that the available multi-link information allows us to achieve substantially better results than state-of-the-art single link or averaging approaches, that is, those that take the average of the information of all channels instead of taking them individually. We show experimentally how the addition of each of the multiple links information helps to improve the accuracy of the prediction from 44% with one link to 99% with 6 links.
A Survey on Machine Learning-Based Performance Improvement of Wireless Networks: PHY, MAC and Network Layer
Authors: Kulin Merima , Kazaz Tarik , De Poorter Eli , Moerman Ingrid
Published: January 2021

This paper presents a systematic and comprehensive survey that reviews the latest research efforts focused on machine learning (ML) based performance improvement of wireless networks, while considering all layers of the protocol stack: PHY, MAC and network. First, the related work and paper contributions are discussed, followed by providing the necessary background on data-driven approaches and machine learning to help non-machine learning experts understand all discussed techniques. Then, a comprehensive review is presented on works employing ML-based approaches to optimize the wireless communication parameters settings to achieve improved network quality-of-service (QoS) and quality-of-experience (QoE). We first categorize these works into: radio analysis, MAC analysis and network prediction approaches, followed by subcategories within each. Finally, open challenges and broader perspectives are discussed.
Leaching via Weak Spots in Photovoltaic Modules
Authors: Nover Jessica , Zapf-Gottwick Renate , Feifel Carolin , Koch Michael , Werner Juergen Heinz
Published: January 2021

This study identifies unstable and soluble layers in commercial photovoltaic modules during 1.5 year long-term leaching. Our experiments cover modules from all major photovoltaic technologies containing solar cells from crystalline silicon (c-Si), amorphous silicon (a-Si), cadmium telluride (CdTe), and copper indium gallium diselenide (CIGS). These technologies cover more than 99.9% of the world market. We cut out module pieces of 5 × 5 cm2 in size from these modules and leached them in water-based solutions with pH 4, pH 7, and pH 11, in order to simulate different environmental conditions. Unstable layers open penetration paths for water-based solutions; finally, the leaching results in delamination. In CdTe containing module pieces, the CdTe itself and the back contact are unstable and highly soluble. In CIGS containing module pieces, all of the module layers are more or less soluble. In the case of c-Si module pieces, the cells’ aluminum back contact is unstable. Module pieces from a-Si technology also show a soluble back contact. Long-term leaching leads to delamination in all kinds of module pieces; delamination depends strongly on the pH value of the solutions. For low pH-values, the time dependent leaching is well described by an exponential saturation behavior and a leaching time constant. The time constant depends on the pH, as well as on accelerating conditions such as increased temperature and/or agitation. Our long-term experiments clearly demonstrate that it is possible to leach out all, or at least a large amount, of the (toxic) elements from the photovoltaic modules. It is therefore not sufficient to carry out experiments just over 24 h and to conclude on the stability and environmental impact of photovoltaic modules.
Analysis of Control Strategies Based on Virtual Inertia for the Improvement of Frequency Stability in an Islanded Grid with Wind Generators and Battery Energy Storage Systems
Authors: Pazmiño Iván , Martinez Sergio , Ochoa Danny
Published: January 2021

Rising levels of non-synchronous generation in power systems are leading to increasing difficulties in primary frequency control. In response, there has been much research effort aimed at providing individual electronic interfaced generators with different frequency response capabilities. There is now a growing research interest in analyzing the interactions among different power system elements that include these features. This paper explores how the implementation of control strategies based on the concept of virtual inertia can help to improve frequency stability. More specifically, the work is focused on islanded systems with high share of wind generation interacting with battery energy storage systems. The paper presents a methodology for modeling a power system with virtual primary frequency control, as an aid to power system planning and operation. The methodology and its implementation are illustrated with a real case study.
Design and Thermodynamic Analysis of Waste Heat-Driven Zeolite–Water Continuous-Adsorption Refrigeration and Heat Pump System for Ships
Authors: Ezgi Cüneyt
Published: January 2021

Strict International Maritime Organization (IMO) rules enable ships to maximize fuel consumption and compliance with the climate. Cooling and heat-pumping technology powered by waste heat makes a substantial contribution to lowering ship gas emissions. This study explores, technically studies, and thermodynamically analyzes the efficiency of ongoing adsorption refrigeration and heating systems using a zeolite–water pair onboard a naval surface ship. An updated Dubin-in-Astakhov equation calculates the equilibrium adsorption potential of the operating pair used in the system. The coefficient of performance (COP) and specific cooling power (SCP)/specific heating power (SHP) values were between 0.109 and 0.384 and between 69.13 and 193.58 W kg−1 for cooling mode, and between 66.16 and 185.26 W kg−1 based on exhaust gas temperature and regeneration, respectively. Up to 27.64% and 52.91% met the cooling and heating load of the case vessel at a full load by the zeolite–water-adsorbed refrigeration/heat-pumping system. The COP of the heat pump and cooling systems was compared to that of adsorption cooling/heat pumps in the literature.
Relative Stability of Electrical into Mechanical Conversion with BLDC Motor-Cascade Control
Authors: Sobieraj Sylwester , Sieklucki Grzegorz , Gromba Józef
Published: January 2021

The conversion of the electrical energy into the mechanical is usually realized by a motor, power electronics and cascade control. The relative stability (Θ-stability), i.e., the displacement of its eigenvalues of this system is analyzed for a drive with a BLDC motor. The influence of changing the basic parameters of the motor and power supply system on the drive operation is considered. 4th order closed-loop transfer-function of the cascade control is presented, where boundaries of the transfer-function coefficients are used. The cascade system which uncertainty of the resistance, inductance, flux and gain parameters is analyzed. Theoretical calculations for the cascade control, simulations and laboratory tests are included in the article.
Optimizing the Geometric Parameters of a Straight-Through Labyrinth Seal to Minimize the Leakage Flow Rate and the Discharge Coefficient
Authors: Baek Seung Il , Ahn Joon
Published: January 2021

A straight-through labyrinth seal is one of the most popular non-contacting annular seals through which energy dissipation by turbulence viscosity interaction is achieved with a series of teeth and cavities. The geometric parameters of the straight-through labyrinth seal, such as clearance, tooth width, tooth height, cavity width, and tooth inclination angle, affect its performance. The space for installing a labyrinth seal in turbomachinery is limited, and so it is important to optimize its geometry for a fixed axial length in order to minimize the leakage flow rate and the discharge coefficient. The objective of the current study is to understand the effects of changing the geometric parameters of the seal on the leakage flow rate and the discharge coefficient, and to determine the optimized geometry for a fixed axial length. When the whole axial length is fixed, the most effective way to decrease the discharge coefficient is to reduce the cavity width by increasing the number of cavities. However, if the number of cavities is too high, the beneficial effect of more cavities can be reversed. The results of this study will help turbomachinery manufacturers to design a more efficient labyrinth seal. Numerical simulations of leakage flow for the straight-through labyrinth seal were carried out using Reynolds-Averaged Navier–Stokes (RANS) models, and the results for their discharge coefficients and pressure distributions were compared to previously published experimental data.
Expression Signatures of microRNAs and Their Targeted Pathways in the Adipose Tissue of Chickens during the Transition from Embryonic to Post-Hatch Development
Authors: Hicks Julie A. , Liu Hsiao-Ching
Published: January 2021

As the chick transitions from embryonic to post-hatching life, its metabolism must quickly undergo a dramatic switch in its major energy source. The chick embryo derives most of its energy from the yolk, a lipid-rich/carbohydrate-poor source. Upon hatching, the chick’s metabolism must then be able to utilize a lipid-poor/carbohydrate-rich source (feed) as its main form of energy. We recently found that a number of hepatically-expressed microRNAs (miRNAs) help facilitate this shift in metabolic processes in the chick liver, the main site of lipogenesis. While adipose tissue was initially thought to mainly serve as a lipid storage site, it is now known to carry many metabolic, endocrine, and immunological functions. Therefore, it would be expected that adipose tissue is also an important factor in the metabolic switch. To that end, we used next generation sequencing (NGS) and real-time quantitative PCR (RT-qPCR) to generate miRNome and transcriptome signatures of the adipose tissue during the transition from late embryonic to early post-hatch development. As adipose tissue is well known to produce inflammatory and other immune factors, we used SPF white leghorns to generate the initial miRNome and transcriptome signatures to minimize complications from external factors (e.g., pathogenic infections) and ensure the identification of bona fide switch-associated miRNAs and transcripts. We then examined their expression signatures in the adipose tissue of broilers (Ross 708). Using E18 embryos as representative of pre-switching metabolism and D3 chicks as a representative of post-switching metabolism, we identified a group of miRNAs which work concordantly to regulate a diverse but interconnected group of developmental, immune and metabolic processes in the adipose tissue during the metabolic switch. Network mapping suggests that during the first days post-hatch, despite the consumption of feed, the chick is still heavily reliant upon adipose tissue lipid stores for energy production, and is not yet efficiently using their new energy source for de novo lipid storage. A number of core master regulatory pathways including, circadian rhythm transcriptional regulation and growth hormone (GH) signaling, likely work in concert with miRNAs to maintain an essential balance between adipogenic, lipolytic, developmental, and immunological processes in the adipose tissue during the metabolic switch.
Investigation of an Alternative Marker for Hypermutability Evaluation in Different Tumors
Authors: Chen Anqi , Zhang Suhua , Xiong Lei , Xi Shihan , Tao Ruiyang , Chen Chong , Li Jixi , Chen Jinzhong , Li Chengtao
Published: January 2021

A growing number of studies have shown immunotherapy to be a promising treatment strategy for several types of cancer. Short tandem repeats (STRs) have been proven to be alternative markers for the evaluation of hypermutability in gastrointestinal (GI) cancers. However, the status of STRs and microsatellite instability (MSI) in other tumors have not yet been investigated. To further compare STR and MSI alterations in different tumors, a total of 407 paired DNAs were analyzed from the following eight tumor types: breast cancer (BC), hepatocellular cancer (HCC), pancreatic cancer (PC), colorectal cancer (CRC), gastric cancer (GC), lung cancer (LC), esophageal cancer (EC), and renal cell cancer (RCC). The STR alteration frequencies varied in different tumors as expected. Interestingly, none of the patients possessed MSI-low (MSI-L) or MSI-high (MSI-H), except for the GI patients. The highest STR alteration was detected in EC (77.78%), followed by CRC (69.77%), HCC (63.33%), GC (54.55%), LC (48.00%), RCC (40.91%), BC (36.11%), and PC (25.71%). The potential cutoff for hypermutability was predicted using the published objective response rate (ORR), and the cutoff of LC and HCC was the same as that of GI cancers (26.32%). The cutoffs of 31.58% and 10.53% should be selected for BC and RCC, respectively. In summary, we compared MSI and STR status in eight tumor types, and predicted the potential threshold for hypermutability of BC, HCC, CRC, GC, LC, EC, and RCC.
Intracytoplasmic Sperm Injection in Cattle
Authors: Unnikrishnan Veena , Kastelic John , Thundathil Jacob
Published: January 2021

Intracytoplasmic sperm injection (ICSI) involves the microinjection of sperm into a matured oocyte. Although this reproductive technology is successfully used in humans and many animal species, the efficiency of this procedure is low in the bovine species mainly due to failed oocyte activation following sperm microinjection. This review discusses various reasons for the low efficiency of ICSI in cattle, potential solutions, and future directions for research in this area, emphasizing the contributions of testis-specific isoforms of Na/K-ATPase (ATP1A4) and phospholipase C zeta (PLC ζ). Improving the efficiency of bovine ICSI would benefit the cattle breeding industries by effectively utilizing semen from elite sires at their earliest possible age.
Perspectives on Snow Avalanche Dynamics Research
Authors: Nishimura Kouichi , Barpi Fabrizio , Issler Dieter
Published: January 2021

As an introduction for non-specialists to the Special Issue on snow avalanche dynamics, this paper first outlines how understanding the dynamics of snow avalanches can contribute to reducing risk for settlements and infrastructure. The main knowledge gaps in this field of research concern (i) the properties of the flow regimes and the transitions between them, and (ii) the dynamics of mass change due to erosion and deposition. These two aspects are intertwined and determine not only the reach of an avalanche, but also its velocity, course and impact pressure. Experimental studies described in this Special Issue comprise a wide range of scales from small rotating drums to real snow avalanches. In addition, several papers describe post-event field surveys of specific avalanches and analyze them using different methods and techniques, demonstrating how valuable qualitative insight can be gained in this way. The theoretical developments range from exploratory studies of fluid–particle interactions to a comprehensive review of half a century of avalanche flow modeling in Russia.
Alleviation of Heat Stress in Tomato by Exogenous Application of Sulfur
Authors: Ali Muhammad Moaaz , Waleed Shafique Muhammad , Gull Shaista , Afzal Naveed Waleed , Javed Talha , Yousef Ahmed Fathy , Mauro Rosario Paolo
Published: January 2021

Temperature is a key factor influencing plant growth and productivity, however sudden increases in temperature can cause severe consequences in terms of crop performance. We evaluated the influence of elementary sulfur application on the physiology and growth of two tomato genotypes (“Ahmar” and “Roma”) grown in two growth chambers (at 25 and 45 °C). Plants were sprayed with 2, 4, 6, and 8 ppm sulfur 45 days after sowing (untreated plants were kept as control). Plants of the “Roma” cultivar receiving 6 ppm sulfur exhibited maximal shoot and root biomass values followed by those receiving 4 ppm under both temperature conditions. Maximal CO2 index, photosynthetic rate, transpiration rate, and greenness index values (188.1 µmol mol−1, 36.3 µmol CO2 m−2 s−1, 1.8 µmol H2O m−2 s−1, and 95 SPAD, respectively) were observed in plants of “Roma” cultivar grown at 25 °C, indicating positive influences of sulfur on tomato physiology. Similarly, sulfur maximized proline, nitrogen, phosphorus, and potassium contents in leaves of both genotypes at both temperatures. The differences between control and sulfur-treated plants grown under heat stress indicate a possible role of sulfur in mitigating heat stress. Overall, our results suggest that 6 ppm of sulfur is the best dose to alleviate tomato heat stress and enhance the morphological, physiological, and biochemical attributes of tomato plants.
Associations of Problematic Binge-Watching with Depression, Social Interaction Anxiety, and Loneliness
Authors: Sun Jia-Ji , Chang Yen-Jung
Published: January 2021

Background: Binge-watching refers to the watching of several episodes of a TV series or program in rapid succession. This study aims to investigate the associations of binge-watching behavior with depression, social interaction anxiety, and loneliness risks among adults in Taiwan. Methods: A cross-sectional online survey was conducted in October 2018, in which data from 1488 participants were collected using a self-administered questionnaire comprising four valid and reliable scales: the Center for Epidemiologic Studied Depression Scale (CES-D), the Chinese version of the Social Interaction Anxiety Scale (SIAS-C), the UCLA Loneliness Scale (version 3), and the Problematic Series Watching Scale (PSWS). Results: Among the surveyed participants, the mean age was 28.3, and most participants were women who had completed undergraduate education. Multiple regression analysis demonstrated that, after adjustments for sociodemographic characteristics and self-reported health statuses, the score on the problematic binge-watching scale was positively associated with the scores on the depression, social interaction anxiety, and loneliness scales (p < 0.001 for each model). Conclusions: Problematic binge-watching was associated with increased depression, social interaction anxiety, and loneliness risks among adults in Taiwan. Additional studies on the relationship between problematic binge-watching and mental health problems, as well as its potential mechanism, are warranted.
Impact of the COVID-19 Pandemic on Psychiatric Admissions to a Large Swiss Emergency Department: An Observational Study
Authors: Ambrosetti Julia , Macheret Laura , Folliet Aline , Wullschleger Alexandre , Amerio Andrea , Aguglia Andrea , Serafini Gianluca , Prada Paco , Kaiser Stefan , Bondolfi Guido , Sarasin François , Costanza Alessandra
Published: January 2021

The coronavirus disease 2019 (COVID-19) pandemic is a public health emergency with profound mental health consequences. The psychiatric emergency department (ED) plays a key role during this mental health crisis. This study aimed to investigate differences in admissions at a Swiss psychiatric ED from 1 April to 15 May during a “pandemic-free” period in 2016 and a “during-pandemic” period in 2020. The study included 579 consultations at psychiatric ED in the “during-pandemic” period and 702 in the “pandemic-free” period. Sociodemographic and clinical characteristics were compared, and logistic regression analysis was performed to identify variables associated with psychiatric admissions during the pandemic. A reduction in total psychiatric ED admissions was documented during COVID-19. Logistic regression analysis predicted the independent variable (ED admission during the pandemic) and estimated odds ratio (OR) for being unmarried/not in a relationship, arrival in an ambulance, suicidal behavior, behavioral disorders and psychomotor agitation. Though only statistically significant in bivariate analysis, patients were also more likely to be involuntarily hospitalized. This picture appears to be reversed from a sociodemographic and clinical point of view to our observation of psychiatric ED consultation in 2016. These findings highlight that the reduction in psychiatric ED admissions during the pandemic seems to be associated with living alone and more severe psychopathologies, which must alert psychiatrists to ensure access to mental health care in times of pandemic.
Physical Activity Recommendations in the Context of New Calls for Change in Physical Education
Authors: Frömel Karel , Vašíčková Jana , Skalik Krzysztof , Svozil Zbyněk , Groffik Dorota , Mitáš Josef
Published: January 2021

The current social, health, and educational changes in society require an adequate response in school-based physical activity (PA), including physical education (PE) lessons. The objective of this study was to identify the real average step counts of Czech and Polish adolescents during PE lessons, and propose recommendations for improving PE programs. This research was carried out in 143 Czech and 99 Polish schools. In the research, a total of 4911 adolescents aged 12–18 years were analyzed as part of teaching practice and 1827 in the context of habitual school practice. Steps were monitored using pedometers. The average step count per PE lesson was 2390 in Czech and Polish boys, while girls achieved 1851 steps. In both countries, boys were subject to greater physical strain in PE lessons compared to girls, both in teaching practice (F(4088,3) = 154.49, p < 0.001, ηp2 = 0.102) and school practice (F(1552,3) = 70.66, p < 0.001, ηp2 = 0.103). Therefore, the priority in PE lessons is to increase the amount of PA for girls, achieve the objectives of PE during PA, and use wearables to improve awareness of PA and improve physical literacy, as well as to support hybrid and online PE as a complement to traditional PE.
Development, Implementation and First Evaluation of an Online Portal to Promote the Mental Health of University Students (me@JGU)
Authors: Lutz-Kopp Caroline , Luka-Krausgrill Ursula , Honsbrok Bettina , Meinhardt-Injac Bozana , Gropalis Maria
Published: January 2021

Background: University students encounter various stressors such as exam preparation, workload and economic concerns. Having to deal with a multitude of stressors can lead to mental health problems and have a negative impact on academic outcomes in students attending university. This paper describes the development and usability evaluation of an open and easily accessible online portal (me@JGU) designed to help students build skills they need to cope with common stressors and manage their own mental health. Methods: We developed a website that addresses the most common stressors among university students and offers strategies for dealing with difficult situations. Initial evaluation results were collected using website statistics and a short anonymous survey regarding the attractiveness and usability of the website. Results: Over an eight-month period, there were 5739 visitors, a total of 16,495 page views and 3748 downloads. The survey results indicate that me@JGU covers relevant topics and that the students like the layout. Conclusions: Online interventions promoting mental health of university populations are easily accessible and cost effective for large populations. They may prevent study difficulties, inform students about mental health and offer possible solutions. In addition, at-risk students can receive information about other relevant resources, and feel encouraged to access support and treatment.
Physical Activity and Plasma Glucose Control among Diabetic Patients Attending Outpatients Clinics in Hanoi, Vietnam
Authors: Nguyen Tam Ngoc , Nguyen Tam Thi , Hagströmer Maria , Pham Thang , van der Ploeg Ingeborg , Sundberg Carl Johan , Vu Huyen Thi Thanh
Published: January 2021

Reaching the recommendation on physical activity (PA) for health is highly important to effectively manage blood glucose in patients with type 2 diabetes (T2D). The aims of this study were to assess the level and pattern of PA among T2D outpatients and to relate PA levels to glucose control. A cross-sectional study was conducted in outpatient clinics in Hanoi, Vietnam. PA levels were reported using the Global Physical Activity Questionnaire (GPAQ) version 2.0. Participants meeting the WHO recommendations on PA for health or not were respectively categorized as “sufficiently active” and “insufficiently active”. FPG < 7.2 mmol/L was defined as controlled plasma glucose. In total, 407 participants with T2D (55% women, mean (SD) age 61.6 (9.7) years) were included. The fraction of T2D outpatients reporting as insufficiently active was 21%. The lowest amount of energy expenditure was from transport activities (travel from and to places). On multivariate logistic regression, being sufficiently active was associated with a two-fold increased likelihood of having better glycemic control. The findings warrant action plans to increase physical activity in general and in specific active transport for T2D patients in Vietnam.
Numerical Analysis on the Thermal Performance in an Excavating Roadway with Auxiliary Ventilation System
Authors: Li Zijun , Liu Huasen , Xu Yu , Li Rongrong , Jia Mintao , Zhang Mengsheng
Published: January 2021

A steady and proper thermal environment in deep underground is imperative to ensure worker health and production safety. Understanding the thermal performance in the roadway is the premise of temperature prediction; ventilation design; and improvement in cooling efficiency. A full coupled model incorporated with a moving mesh method was adopted; reflecting the dynamic condition of roadway construction. This study revealed the characteristics of the thermal performance and its evolution law in an excavating roadway. Several scenarios were performed to examine the designs of the auxiliary ventilation system on thermal performance in the roadway. The results show that there is a limitation in the cooling effect by continuously increasing the ventilation volume. Reducing the diameter of the air duct or distances between the duct outlet and the working face will aggravate the heat hazard in the roadway. The heat release from the roadway wall increases with the increase of the advance rate of the working face or roadway section size. Furthermore; an orthogonal experiment was conducted to investigate the effect of major factors on the average air temperature and local heat accumulation in the roadway
Searching beyond the Lamppost to Reduce Breast Cancer Disparities
Authors: Gehlert Sarah , Kavanaugh-Lynch Marion , Fernandez Poole Senaida
Published: January 2021

Racial and ethnic differences in breast cancer occur by race/ethnicity in both incidence and mortality rates. Women of lower socioeconomic status likewise have poorer outcomes. When race alone is considered, incidence rates in the United States are highest among White women (130.8 per 100,000), with Black women close behind (126.7 per 100,000). Incidence is lowest among Asian/Pacific Islander women, at 93.2 per 100,000. Mortality differences are more pronounced, with Black women 40% more likely to die from breast cancer than White women (28.4 per 100,000 and 20.3 per 100,000, respectively). Mortality rates for Asian/Pacific Islander women (11.5 per 100,000) are far lower than for Black and White women. When age is considered, additional differences between Black and White women appear, in part accounted for by types of breast cancer experienced. Women of other racial/ethnic groups and socioeconomic status have received less scientific attention. In this article, we provide a brief overview of the evidence for social determinants of breast cancer and argue that the current reliance on race over racism and ethnicity contributes to our inability to eliminate breast cancer disparities in the United States and elsewhere in the world. We suggest alternatives to the current approach to research in breast cancer disparities.
Reply to Seafarers’ Occupational Noise Exposure and Cardiovascular Risk. Comments to Bolm-Audorff, U.; et al. Occupational Noise and Hypertension Risk: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2020, 17, 6281
Authors: Bolm-Audorff Ulrich , Hegewald Janice , Pretzsch Anna , Freiberg Alice , Nienhaus Albert , Seidler Andreas
Published: January 2021

We are grateful for the insightful comments in [...]
Dyadic Invariance of the Positive Sexuality Scale in Chilean Heterosexual Couples
Authors: Casu Giulia , Guzmán-González Mónica , Espinoza-Tapia Ricardo , Garrido-Rojas Lusmenia , Barrientos Jaime , Gómez Fabiola
Published: January 2021

Gender differences in sexuality-related dimensions have long been investigated in close relationship research. An important assumption when comparing values across gender in dyadic research is that both partners conceptualize the construct under investigation in the same way. Thus, issues of measurement invariance should be considered when working with dyadic data. The aim of the present study was to test the dyadic invariance of the Positive Sexuality Scale (PSS) to assess an individual’s sense of happiness and fulfillment with his/her sexual expression. The PSS was completed by 166 Chilean heterosexual couples, and measurement invariance was tested using confirmatory factor analysis within a dyadic framework. Configural, metric, scalar, and partial strict measurement invariance were supported for the PSS original one-factor model. No between-partner difference was found in the PSS latent factor mean. The functioning of the PSS and the meaning attributed to positive sexuality were the same for both partners. Hence, variations in the PSS levels between both partners in heterosexual couples can be interpreted as true mean differences rather than measurement artifacts.
Trends in Incidence and Mortality of Primary Liver Cancer in Lithuania 1998–2015
Authors: Dulskas Audrius , Kavaliauskas Povilas , Zagminas Kestutis , Jancoriene Ligita , Smailyte Giedre
Published: January 2021

Background: Recently, reports have suggested that rates of liver cancer have increased during the last decades in developed countries; increasing hepatocellular carcinoma and cholangiocarcinoma rates were reported. The aim of this study was to examine time trends in incidence and mortality rates of liver cancer for the period of 1998–2015 in Lithuania by sex, age, and histology. Methods: We examined the incidence of liver cancer from 1998 to 2015 using data from the Lithuanian Cancer Registry. Age-standardized incidence rates were calculated by sex, age, and histology. Trends were analyzed using the Joinpoint Regression Program to estimate the annual percent change. Results: A total of 3086 primary liver cancer cases were diagnosed, and 2923 patients died from liver cancer. The total number of liver cancer cases changed from 132 in 1998 to 239 in 2015. Liver cancer incidence rates changed during the study period from 5.02/100,000 in 1998 to 10.54/100,000 in 2015 in men and from 2.43/100,000 in 1998 to 6.25/100,000 in 2015 in women. Annual percentage changes (APCs) in the age-standardized rates over this period were 4.5% for incidence and 3.6% for mortality. Hepatocellular cancer incidence rates were stable from 1998 to 2005 (APC −5.9, p = 0.1) and later increased by 6.7% per year (p < 0.001). Intrahepatic ductal carcinoma incidence increased by 8.9% per year throughout the study period. The rise in incidence was observed in all age groups; however, in age groups < 50 and between 70 and 79 years, observed changes were not statistically significant. For mortality, the significant point of trend change was detected in 2001, where after stable mortality, rates started to increase by 2.4% per year. Conclusions: Primary liver cancer incidence and mortality increased in both sexes in Lithuania. The rise om incidence was observed in both sexes and main histology groups. The increasing incidence trend may be related to the prevalence of main risk factors (alcohol consumption, hepatitis B and C infections. and diabetes).
Risk Factors of Undiagnosed Diabetes Mellitus among Korean Adults: A National Cross-Sectional Study Using the KNHANES Data
Authors: Lee Sangwon , Ryu Kwang Sun , Kang Ha Ye Jin , You Na Young , Choi Kui Son , Hwangbo Yul , Lee Jae Wook , Cha Hyo Soung
Published: January 2021

In this cross-sectional study, we investigated the baseline risk factors of diabetes mellitus (DM) in patients with undiagnosed DM (UDM). We utilized the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2017 data. Data regarding the participants’ demographic characteristics, health status, health determinants, healthcare accessibility, and laboratory tests were gathered to explore the differences between the DM, UDM, and without-DM groups. Among the 64,759 individuals who participated in the KNHANES 2010–2017, 32,611 individuals aged ≥20 years with fasting plasma glucose levels of <100 or ≥126 mg/dL were selected. The odds ratios (ORs) regarding family history of diabetes and the performance of national health and cancer screening tests were lower in the UDM group than in the DM group (adjusted OR: 0.54; 95% confidence interval (CI): 0.43, 0.66; adjusted OR: 0.74; 95% CI: 0.62, 0.89; adjusted OR: 0.71; 95% CI: 0.60, 0.85). The ORs of hypertension and obesity were higher in the UDM group than in the DM group (adjusted OR: 1.32; 95% CI: 1.06, 1.64; adjusted OR: 1.80; 95% CI: 1.37, 2.36, respectively). Patients with UDM were more likely to be exposed to DM-related risk factors than those with and without DM. Public health interventions to prevent UDM development are necessary.
Heterogeneous Urban Exposures and Prevalent Hypertension in the Helsinki Capital Region, Finland
Authors: Okokon Enembe O. , Yli-Tuomi Tarja , Siponen Taina , Tiittanen Pekka , Turunen Anu W. , Kangas Leena , Karppinen Ari , Kukkonen Jaakko , Lanki Timo
Published: January 2021

Urban dwellers are simultaneously exposed to several environmental health risk factors. This study aimed to examine the relationship between long-term exposure to fine particulate matter (PM2.5, diameter < 2.5 µm) of residential-wood-burning and road-traffic origin, road-traffic noise, green space around participants’ homes, and hypertension. In 2015 and 2016, we conducted a survey of residents of the Helsinki Capital Region to determine their perceptions of environmental quality and safety, lifestyles, and health statuses. Recent antihypertensive medication was used as an indicator of current hypertensive illness. Individual-level exposure was estimated by linking residential coordinates with modelled outdoor levels of wood-smoke- and traffic-related PM2.5, road-traffic noise, and coverage of natural spaces. Relationships between exposure and hypertension were modelled using multi-exposure and single-exposure binary logistic regression while taking smooth functions into account. Twenty-eight percent of the participants were current users of antihypertensive medication. The odds ratios (95% confidence interval) for antihypertensive use were 1.12 (0.78–1.57); 0.97 (0.76–1.26); 0.98 (0.93–1.04) and 0.99 (0.94–1.04) for wood-smoke PM2.5, road-traffic PM2.5, road-traffic noise, and coverage of green space, respectively. We found no evidence of an effect of the investigated urban exposures on prevalent hypertension in the Helsinki Capital Region.
Biological Control of a Phytosanitary Pest (Thaumatotibia leucotreta): A Case Study
Authors: Moore Sean D.
Published: January 2021

Thaumatotibia leucotreta, known as the false codling moth, is a pest of citrus and other crops in sub-Saharan Africa. As it is endemic to this region and as South Africa exports most of its citrus around the world, T. leucotreta has phytosanitary status for most markets. This means that there is zero tolerance for any infestation with live larvae in the market. Consequently, control measures prior to exporting must be exemplary. Certain markets require a standalone postharvest disinfestation treatment for T. leucotreta. However, the European Union accepts a systems approach, consisting of three measures and numerous components within these measures. Although effective preharvest control measures are important under all circumstances, they are most critical where a standalone postharvest disinfestation treatment is not applied, such as within a systems approach. Conventional wisdom may lead a belief that effective chemical control tools are imperative to achieve this end. However, we demonstrate that it is possible to effectively control T. leucotreta to a level acceptable for a phytosanitary market, using only biological control tools. This includes parasitoids, predators, microbial control, semiochemicals, and sterile insects. Simultaneously, on-farm and environmental safety is improved and compliance with the increasing stringency of chemical residue requirements imposed by markets is achieved.
A Systematic Review Protocol to Identify the Key Benefits and Efficacy of Nature-Based Learning in Outdoor Educational Settings
Authors: Mann Jeff , Gray Tonia , Truong Son , Sahlberg Pasi , Bentsen Peter , Passy Rowena , Ho Susanna , Ward Kumara , Cowper Rachel
Published: January 2021

Outdoor Learning in natural environments is a burgeoning approach in the educational sector. However, the evidence-base of research has not kept pace with teacher perceptions and increased practitioner usage. Anecdotal evidence and formal research suggest the significant health and wellbeing benefits of nature connection. Offering low-cost, non-invasive pedagogical solutions to public health challenges—particularly around mental health, wellbeing, physical literacy, and increasing physical activity–the pedagogical benefits of Outdoor Learning are yet to be fully enunciated. The proposed systematic review will search for studies across eight academic databases which measure the academic and socio-emotional benefits of Outdoor Learning, with a focus on school-aged educational settings. Using the inclusion criteria set out in this paper (and registered with PROSPERO: CRD42020153171), relevant studies will be identified then summarised to provide a synthesis of the current literature on Outdoor Learning. The goal of this review is to document the widespread international investigation into Outdoor Learning and its associated benefits for development, wellbeing, and personal growth. The systematic review will provide insights for teacher-training institutions, educational policy makers, and frontline teachers to improve the learning experiences of future students.
Influence of the Growth and Development Check (GDC) on Overweight/Obesity of Children under-5 Years in China: A Propensity Score Analysis
Authors: Duan Chongli , Mei Li , Ge Tingshuai , Jiang Quanbao
Published: January 2021

To improve health and reduce the rapidly increasing prevalence of overweight and obesity in children, the Chinese government has formulated childcare standards, with the Growth and Development Check (GDC) as the main content. However, few studies have evaluated the impact of the GDC on lowering the risk of childhood overweight and obesity. Using the 2014 China Family Dynamics Survey and propensity score matching (PSM), this article examined the impact of the GDC on overweight/obesity in children aged 5 years and younger. The results revealed that the mean Body Mass Index (BMI) was 17.80 kg/m2, and the prevalence of overweight/obesity was 24.62% in children. Children whose parents were aware of the GDC had a lower BMI and a lower risk of overweight/obesity than those whose parents were not aware of it. Children who engaged in the GDC in the last 12 months had a lower BMI and a lower chance of overweight/obesity than those not engaged.
Early-Life Exposure to Environmental Air Pollution and Autism Spectrum Disorder: A Review of Available Evidence
Authors: Imbriani Giovanni , Panico Alessandra , Grassi Tiziana , Idolo Adele , Serio Francesca , Bagordo Francesco , De Filippis Giovanni , De Giorgi Donato , Antonucci Gianfranco , Piscitelli Prisco , Colangelo Manuela , Peccarisi Luigi , Tumolo Maria Rosaria , De Masi Roberto , Miani Alessandro , De Donno Antonella
Published: January 2021

The number of children diagnosed with Autism Spectrum Disorder (ASD) has rapidly increased globally. Genetic and environmental factors both contribute to the development of ASD. Several studies showed linkage between prenatal, early postnatal air pollution exposure and the risk of developing ASD. We reviewed the available literature concerning the relationship between early-life exposure to air pollutants and ASD onset in childhood. We searched on Medline and Scopus for cohort or case-control studies published in English from 1977 to 2020. A total of 20 articles were selected for the review. We found a strong association between maternal exposure to particulate matter (PM) during pregnancy or in the first years of the children’s life and the risk of the ASD. This association was found to be stronger with PM2.5 and less evident with the other pollutants. Current evidence suggest that pregnancy is the period in which exposure to environmental pollutants seems to be most impactful concerning the onset of ASD in children. Air pollution should be considered among the emerging risk factors for ASD. Further epidemiological and toxicological studies should address molecular pathways involved in the development of ASD and determine specific cause–effect associations.
Anxiety and Depression Symptoms and Suicidal Ideation in Japan Rugby Top League Players
Authors: Ojio Yasutaka , Matsunaga Asami , Hatakeyama Kensuke , Kawamura Shin , Horiguchi Masanori , Yoshitani Goro , Kanie Ayako , Horikoshi Masaru , Fujii Chiyo
Published: January 2021

Clinical and research interest is growing in mental health support for elite athletes, based on findings from epidemiological surveys conducted in Australia, the United States, and European countries. However, little is known about the mental health status of elite athletes in Asia, including Japan. In the current study, we examine the prevalence of mental health problems and suicidal ideation and its risk factors in Japan Rugby Top League players. We analyze anonymous web-based self-reported data from 251 currently competing Japan Rugby Top League male players. During the off-season from December 2019 to January 2020, data on anxiety and depression symptoms were collected using the Japanese version of the 6-item Kessler-6. Suicidal ideation was assessed using the Baron Depression Screener for Athletes. Among the players, 81 players (32.3%) had experienced symptoms of mild anxiety and depression during the previous 30 days, while 12 (4.8%) and 13 (5.2%) had suffered from moderate and severe symptoms, respectively. Nineteen athletes (7.6%) reported that they had experienced suicidal ideation during the previous 2 weeks. Players with mental health problems experienced more events in competitions and daily life, including reduced subjective performance, missing opportunities to play during the last season, changes in health condition, and thinking about a career after retirement, compared with players without such problems. Mental health issues in Japan Rugby Top League players, as elite athletes, may be common, and research and practice development is expected in the near future.