bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of HLA Antigens and Steroid Dose on the Course of COVID-19 of Patients After Kidney Transplantation
Authors: Dedinská Ivana , Skálová Petra , Graňák Karol , Vnučák Matej , Baltesová Tatiana , Žilinská Zuzana , Jeseňák Miloš
Published: November 2021

Background: Kidney transplant recipients appear to be at higher risk for critical COVID-19. Our analysis aimed to identify the possible risk factors for a severe course of the COVID-19 disease and to determine the influence of selected human leukocyte antigens (HLAs) on the course of the disease.

Methods: This is a retrospective, multicenter analysis that included patients that were confirmed to be severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positive after kidney transplantation (KT). The group of patients was divided into two subgroups according to the course of the infection, as follows: non-hospitalized and hospitalized.

Results: A total of 186 patients (men, 69.4%) with confirmed SARS-CoV-2 positivity were included in the group. The following independent risk factors for the outcome of hospitalization were identified: the age at the time of infection [odds ratio (OR) = 1.19, P < 0.0001], a body mass index (BMI) >29.9 kg/m2 (OR = 7.21, P < 0.0001), <7.5-mg prednisone dose/day (OR = 2.29, P = 0.0008), and HLA-DQ2 with a protective nature (OR = 0.05, P = 0.0034).

Conclusions: Higher doses of corticosteroids (>7.5 mg/kg) in standard immunosuppressive regimes and HLA-DQ2 appear to be protective factors in our analysis.
Glucocorticoids Elevate Pseudomonas aeruginosa Binding to Airway Epithelium by Upregulating Syndecan-1 Expression
Authors: Liu Dong , Zeng Ying-Ying , Shi Meng-Meng , Qu Jie-Ming
Published: November 2021

Glucocorticoids are commonly used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Inhaled corticosteroids are associated with a significantly increased risk of pneumonia. Syndecan-1 (SDC1) located in the cell membrane of airway epithelial cell is the crucial molecule mediating infections by P. aeruginosa (PA). In the present study, we found that SDC1 expression was upregulated and the adhesion of PA to human bronchial epithelial (HBE) cells increased to 125 and 138%, respectively, after stimulation by dexamethasone or budesonide. The HBE cells knocking down SDC1 showed lower affinity to PA compared with control. CCAAT-enhancer-binding protein β (C/EBP β) and its phosphorylated form participated in the regulation of glucocorticoid to SDC1 for interfering C/EBP β or inhibiting phosphorylation of C/EBP β by LiCl and BIO, which are inhibitors of glycogen synthase kinase 3β (GSK-3β), and could prevent glucocorticoids from upregulating SDC1 expression. One should be cautious in administering glucocorticoids in chronic lung disease because of their property of increasing the expression of SDC1 and PA binding to the airway epithelium.
Long Non-Coding RNA MEG8 Suppresses Hypoxia-Induced Excessive Proliferation, Migration and Inflammation of Vascular Smooth Muscle Cells by Regulation of the miR-195-5p/RECK Axis
Authors: Xu Dexing , Dai Ruozhu , Chi Hao , Ge Wen , Rong Jingfeng
Published: November 2021

It has been recognized that rebalancing the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) helps relieve vascular injury. Presently, we aim to investigate whether long non-coding RNA (lncRNA) maternally expressed 8 (MEG8) plays a role in affecting the excessive proliferation and migration of VSMCs following hypoxia stimulation. A percutaneous transluminal angioplasty balloon dilatation catheter was adopted to establish vascular intimal injury, the levels of MEG8 and miR-195-5p in the carotid artery were tested by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Hypoxia was used to stimulate VSMCs, then the cell counting kit-8 (CCK-8) assay, Transnwell assay, and wound healing assay were conducted to evaluate the proliferation, and migration of VSMCs. The protein levels of RECK (reversion inducing cysteine rich protein with kazal motifs), MMP (matrix metalloproteinase) 3/9/13, COX2 (cytochrome c oxidase subunit II), macrophage inflammatory protein (MIP)-1beta, VCAM-1 (vascular cell adhesion molecule 1), ICAM-1 (intercellular adhesion molecule 1), and HIF-1α (hypoxia inducible factor 1 subunit alpha) were determined by western blot or cellular immunofluorescence. As the data showed, MEG8 was down-regulated in the carotid artery after balloon injury in rats and hypoxia-treated VSMCs, and miR-195-5p was overexpressed. Forced MEG8 overexpression or inhibiting miR-195-5p attenuated hypoxia-promoted cell proliferation and migration of VSMCs. In addition, miR-195-5p up-regulation reversed MEG8-mediated effects. Hypoxia hindered the RECK expression while boosted MMP3/9/13 levels, and the effect was markedly reversed with MEG8 up-regulation or miR-195-5p down-regulation. Mechanistically, MEG8 functioned as a competitive endogenous (ceRNA) by sponging miR-195-5p which targeted RECK. Moreover, the HIF-1α inhibitor PX478 prevented hypoxia-induced proliferation, and migration of VSMCs, upregulated MEG8, and restrained miR-195-5p expression. Overall, lncRNA MEG8 participated in hypoxia-induced excessive proliferation, inflammation and migration of VSMCs through the miR-195-5p/RECK axis.
Radiomics for Identification and Prediction in Metastatic Prostate Cancer: A Review of Studies
Authors: Kendrick Jake , Francis Roslyn , Hassan Ghulam Mubashar , Rowshanfarzad Pejman , Jeraj Robert , Kasisi Collin , Rusanov Branimir , Ebert Martin
Published: November 2021

Metastatic Prostate Cancer (mPCa) is associated with a poor patient prognosis. mPCa spreads throughout the body, often to bones, with spatial and temporal variations that make the clinical management of the disease difficult. The evolution of the disease leads to spatial heterogeneity that is extremely difficult to characterise with solid biopsies. Imaging provides the opportunity to quantify disease spread. Advanced image analytics methods, including radiomics, offer the opportunity to characterise heterogeneity beyond what can be achieved with simple assessment. Radiomics analysis has the potential to yield useful quantitative imaging biomarkers that can improve the early detection of mPCa, predict disease progression, assess response, and potentially inform the choice of treatment procedures. Traditional radiomics analysis involves modelling with hand-crafted features designed using significant domain knowledge. On the other hand, artificial intelligence techniques such as deep learning can facilitate end-to-end automated feature extraction and model generation with minimal human intervention. Radiomics models have the potential to become vital pieces in the oncology workflow, however, the current limitations of the field, such as limited reproducibility, are impeding their translation into clinical practice. This review provides an overview of the radiomics methodology, detailing critical aspects affecting the reproducibility of features, and providing examples of how artificial intelligence techniques can be incorporated into the workflow. The current landscape of publications utilising radiomics methods in the assessment and treatment of mPCa are surveyed and reviewed. Associated studies have incorporated information from multiple imaging modalities, including bone scintigraphy, CT, PET with varying tracers, multiparametric MRI together with clinical covariates, spanning the prediction of progression through to overall survival in varying cohorts. The methodological quality of each study is quantified using the radiomics quality score. Multiple deficits were identified, with the lack of prospective design and external validation highlighted as major impediments to clinical translation. These results inform some recommendations for future directions of the field.
Metabolomics and Whole-Exome Sequencing in Patients with Differential Sensitivity to Sevoflurane: A Protocol for a Prospective Observational Trial
Authors: Wei Yiyong , Zhang Donghang , Zuo Yunxia
Published: November 2021

Introduction: Different sensitivity to volatile anesthetics in Drosophila, nematodes and mice is related to mutation of energy metabolism genes. In clinical practice, we find that the end-tidal sevoflurane concentration (ETsevo) differs among patients at the same depth of anesthesia, indicating that the sensitivity to sevoflurane varies among patients. However, the underlying mechanism remains unclear. The sensitivity of an anesthetic is associated with the postoperative outcomes of patients and the mechanism of action of volatile anesthetics. We therefore propose this protocol to determine whether differences in metabolite profile and genetic variations contribute to patients’ sensitivity to volatile anesthetics.

Methods and Analysis: This is a single-centre, prospective observational study. 720 patients undergoing abdominal surgery were included. General anesthesia was induced with inhaled sevoflurane, a bolus of sufentanil (0.2–0.4 μg/kg) and cis-atracurium (0.2–0.3 mg/kg). The end-tidal sevoflurane concentration (ETsevo) was adjusted to maintain a BIS (bispectral index) value between 40–60. The mean ETsevo from 20 min after endotracheal intubation to 2 h after the beginning of surgery (steady state) was calculated for each patient. Patients were further divided into a high-sensitivity group (mean ETsevo – SD) and a low-sensitivity group (mean ETsevo + SD) to investigate the sensitivity to sevoflurane. Cases were paired from the high-sensitivity group (group H) and low-sensitivity group (group L) according to age, sex, body mass index (BMI), ASA physical status classification, vital signs, BIS, ephedrine use, sufentanildose, and cis-atracurium dose at anesthesia induction and steady state. Differences in metabolite levels, single nucleotide polymorphisms (SNPs) and protein-coding gene sequence variations between group H and group L will be determined through plasma metabolomics, whole-exome sequencing (WES), genome-wide association study (GWAS), and bioinformatics analyses. These results will be analysed to determine the reasons for the differential sensitivity to sevoflurane in humans.

Ethics and Dissemination: This prospective observational study protocol has received ethical approval from the Ethical Committee of West China Hospital of Sichuan University on May 19, 2017 (Approval No. 78). Informed consent will be obtained before patient enrolment. The results will be submitted to international peer-review journals.

Trial Registration Number: ChiCTR1800014327.
Liquid Chromatograph-Mass Spectrometry-Based Non-targeted Metabolomics Discovery of Potential Endogenous Biomarkers Associated With Prostatitis Rats to Reveal the Effects of Magnoflorine
Authors: Yuan Yin , Dong Fei-Xue , Liu Xu , Xiao Hong-Bin , Zhou Zhong-Guang
Published: November 2021

Magnoflorine (Mag) has multiple pharmacological activities for the prevention and treatment of prostatitis. However, its molecular mechanisms andpharmacological targets are not clear. In this study, the ultra-performance liquid tandem mass spectrometry-based metabolomics method was used to clarify the intervention of Mag against prostatitis and the biological mechanism. A total of 25 biomarkers associated with the prostatitis model were identified by metabolomics, and a number of metabolic pathways closely related to the model were obtained by MetPA analysis. After given Mag treatment, the results of each indicator were shown that Mag alkaloid could inhibit the development of prostatitis effectively. We found that Mag had regulative effects on potential biomarkers of prostatitis model, which can regulate them to the control group. Our results indicated that alkaloids have an effective intervention therapy for prostatitis, and five types of metabolic pathways closely related to prostatitis model were obtained, including phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, tyrosine metabolism, arginine and proline metabolism, glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism. This study has provided the basic experimental data for the development of Mag in the prevention and treatment of prostatitis.
The Role of Perceived Organizational Support in Mental Health of Healthcare Workers During the COVID-19 Pandemic: A Cross-Sectional Study
Authors: Chatzittofis Andreas , Constantinidou Anastasia , Artemiadis Artemios , Michailidou Kyriaki , Karanikola Maria N. K.
Published: November 2021

Background: Data support the link between the coronavirus disease 2019 (COVID-19) pandemic and mental distress in healthcare workers (HCWs). Although previous studies have documented the association between organizational policies and employees' psychological and mental status, there is still scant evidence regarding the effect of perceived organizational support (POS) on mental distress in HCWs during the pandemic.

Aims: The present study aimed to assess the association between POS and mental distress in HCWs during the COVID-19 pandemic. The role of POS in stress, depressive and trauma symptoms in HCWs was investigated.

Methods: This was an online cross-sectional study in 424 HCWs. Data were collected during the first wave of the pandemic, and included demographics, a 7-item questionnaire assessing POS, the “Patient Health Questionnaire” assessing depressive symptoms, the “Impact of Events Scale Revised,” measuring post-traumatic stress disorder (PTSD) symptoms and the “Perceived Stress Scale” assessing perceived stress.

Results: The mean POS score was 3.33 [standard deviation:1.85; range 0–7]. Younger (p < 0.001), less experienced (p < 0.001), female (p = 0.002), and non-physician HCWs (p = 0.031) were more likely to report lower self-perceived organizational support than older, male, more experienced physicians. Self-perceived organizational support was significantly and negatively associated with and self-assessed intensity of stress, depressive and traumatic symptoms, after adjusting for putative confounders (p < 0.001).

Discussion: Self-perceived organizational support was significantly associated with HCWs' self-assessed mental status during the pandemic. Organizational support and mental distress should be addressed simultaneously in HCWs during the COVID-19 pandemic to increase resilience among them.
Wilhelm Waldeyer—An Important Scientific Researcher of the 19th Century in the Context of His Memoirs and Major Monographies
Authors: Scheuerlein Hubert , Pape-Köhler Carolina , Köckerling Ferdinand
Published: November 2021

Wilhelm Waldeyer was one of the most important anatomists of his time. The year 2021 marks the 100th anniversary of his death. His name not only lives on in terms such as “Waldeyer's pharyngeal ring” or “Waldeyer's fascia,” he also coined the terms “neuron” and “chromosome.” He produced monumental monographies such as “The Pelvis” and “Ovary and Egg”. Waldeyer's legacy is a large body of lifetime work that continues to impress to this day. However, he also published works that today would be described as racist. His view of a woman's role was and is also controversial. Nevertheless, reading his autobiography (Lebenserinnerungen) today is still beneficial because it vividly illustrates the academic life and a scholarly existence of that era.
Formulación de caso evolucionista: Un lenguaje común en psicoterapia
Authors: Caro García Ciro
Published: November 2021

Formulación de caso evolucionista: Un lenguaje común en psicoterapia es la más reciente contribución a la formulación de caso en psicoterapia en lengua española. Es un modelo parsimonioso para comprender las dificultades de los clientes y para orientar el tratamiento, que pivota sobre la identificación de un tema intersubjetivo disfuncional que compromete al sí mismo, y que se proyecta sobre siete dominios de segundo orden. Aporta esquemas para la valuación, la intervención y la evaluación del proceso de terapia, todo ello desde una perspectiva constructivista evolucionista.
Prácticas Narrativas Colectivas: Intervención en un Grupo de Adultos Mayores de Valparaíso, Chile. Estudio de Intervención Grupal
Authors: Rodríguez-Covarrubias Natalie
Published: November 2021

El presente trabajo es un estudio de intervención grupal centrado en un grupo de adultos mayores que participan en un centro comunitario de la ciudad de Valparaíso, Chile. El objetivo de este estudio es Describir y evaluar un proceso de intervención de un taller de prácticas narrativas colectivas con un grupo de adultos mayores en Valparaíso. La metodología correspondió a una intervención clínica grupal de Prácticas Narrativas Colectivas y técnica de Tree of Life de Denborough y Ncube, siendo adaptada a las necesidades del grupo. Se produjeron datos cualitativos mediante recursos audiovisuales y notas de campo. Además, se aplicó una escala de Depresión Geriátrica GDS de Yesavage en pre y post test. En el análisis cualitativo se reporta un cambio en la percepción identitaria de los participantes. En cuanto a la escala, el tamaño de efecto entre las dos mediciones es relevante ya que se caracteriza como un efecto nivel “medio”. En conclusión, esta perspectiva permite significar y resignificar la experiencia de la adultez mayor a partir de las fortalezas que puedan reconocer en sí mismos y su comunidad. Siendo las prácticas narrativas colectivas un enfoque que rescata sus narrativas en pos de conocer críticamente la experiencia de la adultez mayor.
A Performance Comparison and Enhancement of Animal Species Detection in Images with Various R-CNN Models
Authors: Ibraheam Mai , Li Kin Fun , Gebali Fayez , Sielecki Leonard E.
Published: November 2021

Object detection is one of the vital and challenging tasks of computer vision. It supports a wide range of applications in real life, such as surveillance, shipping, and medical diagnostics. Object detection techniques aim to detect objects of certain target classes in a given image and assign each object to a corresponding class label. These techniques proceed differently in network architecture, training strategy and optimization function. In this paper, we focus on animal species detection as an initial step to mitigate the negative impacts of wildlife–human and wildlife–vehicle encounters in remote wilderness regions and on highways. Our goal is to provide a summary of object detection techniques based on R-CNN models, and to enhance the performance of detecting animal species in accuracy and speed, by using four different R-CNN models and a deformable convolutional neural network. Each model is applied on three wildlife datasets, results are compared and analyzed by using four evaluation metrics. Based on the evaluation, an animal species detection system is proposed.
Using the Social-Ecological Model to Understand the Current Perspective of Contraceptive Use in the United States: A Narrative Literature Review
Authors: Ajayi Kobi V. , Panjwani Sonya , Wilson Kelly , Garney Whitney R.
Published: November 2021

Contraceptive use is deemed one of the 10 greatest public health achievements of the 20th century because its benefits are universally acknowledged as a cornerstone for reducing global maternal morbidity and mortality. However, although the adoption of the Affordable Care Act in the United States (US) enhanced access to preventive health services, as well as increased contraceptive use, a considerable proportion of reproductive-aged women still have unmet reproductive health needs. Current data indicates gaps in contraceptive use patterns in the US, particularly among low-income women and those from racial/ethnic and gender minority subgroups, necessitating further investigation using an ecological approach. This narrative literature review aims to investigate the current perspective of contraceptive use in the US using the social-ecological model (SEM). Based on SEM levels, barriers to contraceptive use entail the following levels: individual (e.g., misbelief about the side effects of contraceptives), interpersonal (e.g., influence of family and friends), institutional (e.g., lack of training on how to use different types of contraceptives), community (e.g., societal stigma and shame), and policy (e.g., restrictive federal and states policies). Access to contraceptives for women is a system-level issue that necessitates consideration for multilevel strategies by key stakeholders to improve contraceptive uptake among vulnerable populations.
Mineral and raw resources and poultry waste to increase soil fertility
Authors: Sannikova N. V. , Kovaleva O. V. , Shulepova О. V. , Bocharova A. A. , Kostomakhin N. M. , Filatov N. F.
Published: November 2021

The purpose of the work was to analyze the use of mineral resources and poultry waste to increase soil fertility in the Tyumen region. According to statistics for 2020 in Russia 45156,3 tons of waste was generated from agriculture, forestry, hunting, fishing and fish farming. On the territory of the Tyumen region 1200 tons of poultry droppings are formed per day. The volume of accumulation is 432,000 tons per year. At the same time, poultry droppings is a source of greenhouse gases, their amount can be: CO₂ – 21,5 million m³, methane – 12,9 million m³ per year. Diatomite is a sedimentary rock consisting of fossilized shells of diatoms, and is a fine powder of gray color. Due to its unique chemical and biological properties, diatomite is widely used in many areas of agriculture as an excellent adsorbent, fertilizer, top dressing for animals and poultry, an environmentally friendly contact insecticide for pest control of grain, fruit and ornamental plants. In order to restore the lost soil fertility in the region (0,6 %, or 2032,2 hectares per year), it is necessary to carry out soil protection measures, as well as the introduction of mineral and organic fertilizers (11,7 million tons of organic fertilizers annually for 15 years). The presence of a large amount of mineral resources and poultry droppings in the Tyumen region makes it possible for researchers to develop the composition and technologies for creating organomineral fertilizers. The implementation of the project based on the technology of using modified diatomite and various types of poultry waste will reduce the amount of waste, reduce the hazard class of bird droppings, the environmental burden of poultry farming on the environment, as well as increase the biological safety and productivity of arable land.
The effectiveness of sunflower cultivation in the Southern chernozems of the Volgograd region by complex pre-sowing seed treatment
Authors: Petrov N. Yu. , Aksenov M. P.
Published: November 2021

Sunflower is the main oilseed crop in Russia, at the same time it is widely used in the feed production. The purpose of the research was to improve the technology of sunflower cultivation in the zone of Southern chernozems in the Volgograd region by conducting a comprehensive presowing seed treatment in an electric field with subsequent seed treatment with a growth regulator in order to increase the yield and quality of oilseeds studied sunflower hybrids. According to the chosen experimental plan, three types of experiments have been carried out. During the first experiment, seeds of sunflower hybrids NK Neoma, LG 5550, EC Petunia have been treated in the alternate current electric field, in the second experiment the seeds have been treated with a growth regulator (the drug “Zerebra Agro”), in the third experiment the seeds have been subjected to a complex effect of electrophysical and biological factors. The level of profitability on sunflower hybrids NK Neoma, LG 5550 and EC Petunia in the control (without treatment) varied in the range of 147–200 %. Processing of sunflower seeds with the drug “Zerebra Agro” contributed to the increase in the level of profitability. On the sunflower hybrid of NK Neoma the profitability level was 178 %, on the sunflower hybrid LG 5550 it was 232 % and on the sunflower hybrid EC Petunia it was 171 %. When processing seeds in the alternate current electric field, the level of profitability was higher than when processing with the drug “Zerebra Agro”. On the sunflower hybrid of NK Neoma, the profitability level was 190 %, on the sunflower hybrid LG 5550 it was 252 % and on the sunflower hybrid EC Petunia it was 184 %. When using complex pre-sowing treatment, the maximum profitability value was achieved for sunflower hybrids NK Neoma, LG 5550 and EC Petunia 230 %, 271 and 201 %, respectively.
The application of phytobiotics in pig breeding
Authors: Belookov A. A. , Belookova O. V. , Chukhutin E. V. , Gorelik O. V.
Published: November 2021

It is impossible to increase the productivity of pigs without organizing a complete balanced feeding, which provides not only a diverse set of feeds, but also stimulating feed additives and preparations. The purpose of the work was to study the effectiveness of the effect of the phytobiotic drug “Intebio” on the reproductive traits of sows and the productivity of the resulting young animals. The feed additive “Intebio” is a mixture of natural essential oils (eucalyptus, garlic, lemon and thyme), citric acid and filler (wheat bran or sunflower meal). It has been found that as a result of the use of the feed additive “Intebio”, the prolificacy of sows in the experimental group was 10,7 heads compared to 10,4 heads in the control group. The weight of piglets at the birth in the experimental group was 1,19 kg, which was 12,3 % higher than in the control group. The weight of the piglets litter at birth was statistically significantly higher in the experimental group 12,97 kg, compared to 11,35 kg in the control group. The livability of piglets for weaning in the experimental group was 100 %, and in the control group it was 93,9 %, the difference was 6,1 abs.%. The absolute weight gain in the live weight of piglets obtained during the experiment from 30 to 105 days in the control group was 26,97 kg, and in the 1st and 2nd experimental groups it was higher by 5,59 and 2,74 kg, respectively. Thus, the use of the phytobiotic feed additive “Intebio” in feeding of t sows in gestation period allowed to increase their prolificacy, the weight of piglets at the birth and their livability for weaning. The use of the feed additive “Intebio” as part of the diet of young pigs allowed to increase the absolute and average daily gains in the live weight of animals.
Prospects for the application of the product life cycle system by means of the planned preventive maintenance module on the example of aviation and agricultural components
Authors: Kolosov S. P.
Published: November 2021

The paper describes an approach to the development of a functional software module within the subsystem of planning, rationing, preventive, routine maintenance, with the functions of accounting for the time of turning operations in the manufacture of machine parts for various purposes, in the general technological chain of the software complex of interacting ERP/MRP/CAD/CAM/CAE technologies of the enterprise, including forecasting both the time of resource operation and the production of necessary components, in order to support manufactured aviation, agricultural and other products throughout the life cycle.
THE IDEA OF TRANSHUMANISM AS A BUILDING BLOCK FOR THE FUTURE WORLD. THE ORIGINS, ESSENCE AND CRITICISM
Authors: Obiedkov Oleksandr
Published: November 2021

The fundamental ideas of transhumanism were first proposed by a British biochemist J. Haldane. In his 1923 essay "Daedalus; or Science and the Future" he describes how scientific and technological discoveries can change society and improve the human condition. In this work, he predicted that the implementation of advanced sciences to human biology would bring great benefits.
These views inspired another researcher, who is still associated with the birth of transhumanism, namely
J. Huxley, who first used the term "Transhumanism" in his work. Under it, Huxley understood humanity’s awareness of the need for self-improvement, or directed revolution.
BIOGRAPHY AND MEDICAL ACTIVITIES OF JOHN HARVEY KELLOGG IN THE FIELD OF PROMOTING A HEALTHY LIFESTYLE
Authors: Kuryliak Valentyna
Published: November 2021

It was discovered that John Harvey Kellogg, with the help and financial support of the White family, began studying to become a doctor at the age of fourteen and headed the Battle Creek Sanatorium at a young age, which under his leadership soon became a world-famous health resort. The publishing activity of Kellogg, who was able to raise the popularity of the magazine “Good Health”, repeatedly published his ideas and recommendations in the field of healthy living. Kellogg has repeatedly heard warnings from Ellen White about trying to separate the Sanatorium from the Seventh-day Adventist Church, namely to make the institution non-denominational without promoting Adventist religious ideas. An inventor, a surgeon, a promoter of a healthy lifestyle, a lecturer who has given about five thousand public speeches – these are just some of the things he has managed to do in his life.
Rancang Bangun Unmanned Surface Vehicle (USV) Dengan Sistem Navigasi Berbasis Kompas Dan Estimasi A-GPS
Authors: Triezani Akbar Maulana , Jatmiko Didit Andri
Published: November 2021

Abstrak – Di zaman sekarang telah hadir suatu sistem yang dinamakan Global Navigation Satellite System (GNSS) untuk mengestimasi posisi sebuah wahana autonomous. Namun pada kenyataannya penerima GNSS kerap mengalami gangguan yang berhubungan dengan akurasi dan kestabilan pembacaan dengan penyebab utama terhalangnya penerima GNSS oleh objek-objek seperti awan tebal, gedung-gedung atau posisi di dalam ruangan. Pada penelitian ini, sistem estimasi posisi dari wahana akan menggunakan pembacaan posisi melalui salah satu fitur dari GNSS yaitu Assisted Global Positioning System (A-GPS) yang ada pada smartphone. Dalam perancangannya, wahana akan menggunakan kompas sebagai penentu arah gerak agar dapat mencapai waypoint dengan akurat. Tujuan pada penelitian ini adalah merancang sistem navigasi yang mampu membuat wahana mencapai waypoint dengan tingkat keandalan yang lebih baik menggunakan kompas dan estimasi dari A-GPS. Metode yang digunakan dalam penelitian ini yaitu menguji wahana untuk mencapai waypoint menggunakan perhitungan jarak dan bearing antara posisi wahana saat ini dan tujuan lalu membandingkan hasil dari sistem estimasi A-GPS dengan Global Positioning System (GPS). Hasil dari penelitian ini didapatkan sistem navigasi wahana menggunakan A-GPS mampu menghasilkan estimasi posisi yang lebih baik dibandingkan GPS dengan tingkat akurasi mencapai 1 hingga 3 meter untuk navigasi secara keseluruhan atau dengan rata-rata 1,5 meter untuk waypoint yang tercapai oleh wahana ketika bernavigasi. Wahana juga teruji mampu menyesuaikan arah gerak menuju waypoint menggunakan sensor kompas dengan simpangan terjauh dari bearing tujuan sebesar 3o. Konsep dari penelitian ini berasal dari premis sistem A-GPSang telah terintegrasi pada smartphone untuk mendapatkan data posisi yang paling relevan tanpa perlu khawatir jika penerima GNSS terhalang oleh cuaca ataupun dalam posisi di dalam ruangan. Maka dari itu, dengan menggabungkan kedua sistem pembacaan tersebut, dapat menghasilkan estimasi posisi yang lebih baik sehingga dapat meningkatkan keandalan dari sebuha wahana untuk bernavigasi secara autonomous. Selain itu, impact penelitian ini juga dapat diterpakan dalam berbagai sistem salah satunya untuk navigasi wahana autonomous.

 

Kata kunci : Autonomous, A-GPS, Kompas, Navigasi, Waypoint.
Sistem Kendali dan Monitoring Parameter Limbah Cair Tahu sebagai Larutan Nutrisi Tanaman Hidroponik Bebasis Internet Of Things
Authors: Mardika Asgia Setya , Rahajoeningroem Tri
Published: November 2021

Abstrak - Pada proses pembuatan tahu, tahu menghasilkan dua macam limbah yaitu limbah padat dan limbah cair. Limbah cair tahu dapat dimanfaatkan menjadi pupuk organik cair. Salah satu cara pengolahan limbah cair tahu dengan menjadikannya pupuk organik cair yaitu melalui pencampuran limbah cair tahu dengan air baku, larutan asam dan juga larutan basa agar dapat dijadikan pupuk organik cair bagi tanaman. Penelitian ini bertujuan untuk merancang sistem monitoring dan kendali yang mampu menghasilkan pupuk organik cair bagi tanaman selada yang dibudidaya secara hidroponik dengan menggunakan mikrokontroler ATMega 2560 dan bantuan rekayasa teknologi berupa Internet of Things (IoT). Penerapan teknologi ini, pada proses pembuatan pupuk organik cair dan juga proses pemupukan salah satunya yakni dengan penerapan teknologi berbasis Internet of Things (IoT). Dimana system ini dapat memberikan informasi penting berupa tingkat kebutuhan nutrisi, suhu serta pH sebagai acuan keberhasilan pemupukan yang dapat di monitoring dan dikendalikan batas kebutuhannya setiap saat. Pupuk organik cair yang dihasilkan dengan bantuan sistem yang dirancang telah memenuhi standarisasi kualitas pupuk organik cair yang memiliki tingkat kepekatan nutrisi dengan kisaran nilai 810,14 ppm sampai 839,81 ppm, kisaran nilai suhu 26,28℃ sampai 27,18℃ dan pH dengan kisaran nilai 6,11 sampai 6,99 dimana hal ini dapat dibuktikan dengan mengacu kepada aturan Surat Keputusan Mentri Pertanian No: 261/KPTS/SR.310/M/4/2019  tentang persyaratan teknis minimal pupuk organik dan PERMEN LH RI No.5 tahun 2004 tentang nilai standar baku mutu limbah. Hasil dari penerapan perancangan sistem ini menghasilkan sayuran selada yang memiliki bobot 25 gram dan tinggi 20 cm.

 

Kata kunci : Limbah Tahu, Pupuk Organik Cair, Internet of Things, Hidroponik, Mikrokontroler Atmega 2560.
Metode Improved Gaussian Sampling pada Algoritma Rapidly Exploring Random Tree*
Authors: Pakaya Habiba Octaviani , Pohan Muhammad Aria Rajasa
Published: November 2021

Penelitian ini bertujuan merancang metode improved gaussian sampling dan mengimplementasikan pada algoritma Rapidly Exploring Random Tree* (RRT*). Perancangan yang dilakukan menggunakan bahasa pemograman Laboratory Virtual Instrumentation Engineering Workbench (LabVIEW). Improved gaussian sampling merupakan pengembangan dari metode gaussian sampling dengan menambahkan jumlah sampling. Jumlah sampling yang digunakan pada metode ini yaitu sejumlah 10 sampling. Untuk mengukur performansi dari metode sampling yang diusulkan, maka kami melakukan perbandingan performansi metode improved gaussian sampling, gaussian sampling dan random sampling. Berdasarkan hasil pengujian improved gaussian sampling didapatkan rata-rata nilai path cost dan waktu komputasi senilai: clutter sepanjang 8,89 dengan waktu 40,05; narrow sepanjang 12,58 dengan waktu 40,03 dan trap sepanjang 9,93 dengan waktu 40,04. Sedangkan hasil pengujian gaussian sampling didapatkan: clutter sepanjang 10 dengan waktu 40,09; narrow sepanjang 13,53 dengan waktu 40,03 dan trap sepanjang 10,95 dengan waktu 40,12. Hasil pengujian random sampling didapatkan: clutter sepanjang 10,86 dengan waktu 0,03; narrow sepanjang 14,82 dengan waktu 0,25 dan trap sepanjang 11,71 dengan waktu 0,21. Disimpulkan bahwa pada algoritma RRT* dengan menggunakan metode improved gaussian sampling menghasilkan performansi yang lebih baik dibandingkan algoritma RRT* yang menggunakan metode sampling lainnya. Hasil perbandingan pengukuran berdasarkan nilai sampling didapatkan rata-rata nilai path cost rata-rata 10,12 dengan jumlah sampling hanya 1 dan nilai path cost terpendek 8,9 dengan jumlah sampling 10.  Berdasarkan pengukuran tersebut didapatkan semakin banyak jumlah sampling yang diberikan maka nilai path cost yang dihasilkan optimal.
Pengaplikasian LabVIEW Sebagai Pengendali Simulasi Tabung Hand Sanitizer
Authors: Ilhamdhani Iqbal
Published: November 2021

Kebutuhan masyarakat akan pentingnya hand sanitizer menjadi salah satu alasan semakin banyaknya jenis dan model hand sanitizer di pasaran. Tetapi, di beberapa tempat seperti sekolah, swalayan, dan perkantoran belum terlihat tabung hand sanitizer yang bisa memberikan informasi kepada admin apabila tabung dalam keadaan kosong. Untuk itu, penulis membuat rancangan dalam bentuk simulasi sistem monitoring tabung hand sanitizer agar mampu memberikan informasi atau notifikasi kepada admin atau pengelola tentang kondisi tabung tersebut. Penelitian ini menggunakan perangkat lunak LabVIEW dengan tampilan antar mukanya front panel, untuk mengintruksikannya melalui block diagram, dengan menggunakan metode penelitiannya yaitu simulasi. Pengujian ini dilakukan dengan menggunakan sensor infrared sebagai pendeteksi objek dalam simulasi untuk menghasilkan cairan yang keluar dari tabung pada tampilan front panel. Dari hasil penelitian, penulis menyimpulkan bahwa simulasi sistem monitoring tabung hand sanitizer berbasis LabVIEW memberikan informasi bahwa ketika sensor mendeteksi objek pada jarak 1-5 cm maka cairan hand sanitizer yang keluar dari tabung rata-rata 0,125 mililiter dengan jeda waktu dari cairan pertama dan cairan kedua keluar selama 2 detik dan pada saat yang bersamaan memberikan informasi atau notifikasi kepada admin. Dari hasil penelitian ini akan berdampak pada keefektifan pengguna atau admin dalam mengontrol setiap tabung hand sanitizer di seluruh lokasi yang di tentukan.
Analisa Performansi Metode Sampling Goal Biasing dan Metode Sampling Gaussian pada Algoritma Rapidly-exploring Random Tree*
Authors: Ferida Dea , Rahajoeningroem Tri
Published: November 2021

Salah satu bidang penelitian mendasar dalam robotika adalah algoritma perencanaan gerak atau jalur. Pada penelitian ini dirancang dan disimulasikan algoritma quick -exploring random tree* (RRT*). Algoritma yang diusulkan adalah algoritma RRT* goal biasing dan algoritma RRT* g aussian sampling . Tujuan penelitian ini adalah melakukan analisa performansi perencanaan jalur algoritma RRT* goal biasing dan algoritma RRT* gaussian sampling . Pengujian dilakukan menggunakan beberapa kasus benchmark yang ada, yaitu lingkungan narrow , trap , dan clutter. Parameter yang dibandingkan adalah biaya, waktu komputasi, dan total node yang dibutuhkan pada pohon pencarian dari node awal sampai node tujuan. Menggunakan kasus benchmark lingkungan narrow, clutter, dan trap algoritma RRT* goal biasing memperoleh nilai rata-rata untuk biaya jarak, waktu, dan jumlah node yaitu; 8,3 (biaiya jarak di narrow ), 222,1 (jumlah node di clutter), dan 30.045 detik (waktu di trap) . Kemudian untuk kasus benchmark lingkungan sempit, clutter, dan trap yang menggunakan algoritma RRT* g aussianmemperoleh nilai rata-rata untuk biaya jarak, waktu, dan jumlah simpul yaitu; 8,1 (biaiya jarak di narrow ), 642,85 (jumlah node di clutter), dan 30,49 detik (waktu di trap) . Berdasarkan pengujian algoritma RRT* goal biasing memiliki keunggulan untuk waktu dan jumlah node yang dibutuhkan untuk mencapai suatu titik, tetapi biaya jarak yang dihasilkan kurang optimal.
Public use and conservation of trails at the Parque Natural Municipal das Andorinhas, Ouro Preto, Brazil
Authors: Machado Simone Fernandes , Fonseca Filho Ricardo Eustáquio , Nogueira Sandra Maria Antunes
Published: November 2021

Several categories of Protected Areas (PAs) established in Brazil allow for public use. However, the impacts resulting from tourist visitation activity in them are poorly researched and technically managed. The central question of the study is how the unplanned opening of trails for tourism purposes can impact the Parque Natural Municipal das Andorinhas (PNMA), a natural park, in Ouro Preto (MG, Brazil). The hypothesis is the understanding that the use of unplanned trails can impact the PA. In this sense, the objective of this work was to analyze nine trails used for tourist visitation at the PNMA. The research methodology included bibliographic and documentary research of the trails, their management, and environmental impacts; elaboration of a structured quali-quantitative form to analyze them; and fieldwork. As a result, it was observed that the main environmental characteristics of tourist interest are the observation of flora and fauna and watercourses; and the main impacts are fires, the irregular opening of trails, and deforestation. It is concluded that knowledge regarding the situation of the trails can help the PA management in their planning and conservation.
Toplumsallaştırılmış Cinsiyet Rolleri Bağlamında Keloğlan Masallarının Kadın Kahramanları
Authors: BAŞARAN Uğur
Published: November 2021

Temel olarak toplumsal hiyerarşide kadınlık ve erkeklik rol ve sorumlulukları ile buna bağlı konular üzerine bina edilen toplumsal cinsiyet çalışmaları, 21. yüzyıldan sonra önemi giderek artan, özellikle de son yıllarda popüler hale gelen bir disiplindir. Her ne kadar çalışma nesnesi olarak erkeğin adı da zikredilse, toplumsal cinsiyet çalışmaları daha çok kadın odaklı çalışmaları kapsamaktadır. Gerek ülkemizde, gerekse dünyada kadının toplumsal nosyonunun tarihsel süreç içerisinde değişime uğraması, beraberinde kadın erkek eşitliğinin/eşitsizliğinin daha çok gündeme gelmesini / tartışılmasını getirmiştir. Bu da, toplumsal cinsiyet çalışmalarını beslemekle birlikte feminizm vb. gibi iddialı ve bir o kadar da taraftar bulan akımların doğmasına vesile olmuştur. Bilhassa iş hayatına atılarak aile ekonomisinde kadının da söz sahibi olması, okuryazar oranında kadının lehine gelişen yükseliş söz konusu durumun doğmasını kolaylaştıran etmenler arasında sayılabilir.Bu makalede, yukarıda kısaca değinilen toplumsal cinsiyet çalışmaları bağlamında Türk masal külliyatı içinde önemli bir yeri olan Keloğlan masallarının kadın kahramanları incelenmiştir. Makalede incelenen masallar, Naki Tezel’in “Türk Masalları” isimli eserinden alınmıştır. Kitaptaki 12 Keloğlan masalında yer alan bütün kadın kahramanlar, “cinsiyet rolleri”, “iktidar-kadın ilişkisi” ve “hegemonik söylem bağlamında kadınlar” alt başlıklarında değerlendirilmiştir. İnceleme neticesinde kadınların gerçek hayattaki genel statü ve değerleriyle, Keloğlan masallarındaki statü ve değerlerinin paralellik arz ettiği ortaya çıkmıştır.
Kadın Kahramanların İzinde Türk Destanları
Authors: ÖZCAN Derya
Published: November 2021

Destanlar, eski ve köklü uygarlıkların bağımsızlıklarını kurma mücadeleleri döneminde ortaya çıkan kahramanlık konulu anlatılardır. Destan çağını yaşayan ulusların gösterdiği hayatta kalma gayreti, yaşadıkları çağdaki en önemli özelliğin kahramanlık olmasını zorunlu kılar. Bu noktada destan kahramanlarında cesaret, alplık ve güç aranan temel niteliklerdir. Erkeğin fiziksel gücüne ihtiyaç duyulan bu kahramanlık çağlarında, destanlarda kadınların da destan kahramanı olacak nitelikte kahramanlık ve cesaret gösterdikleri örnekler bulunmaktadır. Bir kadının tarihin eski çağlarından itibaren bir orduyu yönetecek, ulusunu kurtaracak kadar kahramanlık gösterebilmesi toplumsal yaşama dair fikir vermesi bakımından son derece kıymetlidir. Geleneğin ve kültürün aktarımında ortaya çıktıkları çağ itibariyle oldukça önemli bir yeri olan destanlar, kadın kahramanların var oluş mücadelesi açısından da okunmalıdır. Kadınlık ve erkeklik bilgisinin bir destan metninde işlenişi toplumsal kimliklerin oluşması ve sürdürülmesi bakımından ipuçları taşımaktadır. Bu noktada çalışmanın amacı, Türk dünyası destancılık geleneğinin önemli eserleri başta olmak üzere, destanlardaki kadın kahramanların kadın kimliği ile esere nasıl yansıtıldıkları, hangi konumlarda oldukları, merkezi kahraman veya erkek kahramana yardımcı rollerde oluşları bakımından değerlendirilmeleridir.
Presentación
Authors: Venanzetti Carina
Published: November 2021

Una vez más, con el propósito de socializar sus producciones, la Escuela de Ciencias de la Educación de la Facultad de Humanidades y Artes de la Universidad Nacional de Rosario presenta su Revista Nro. 16, vol. 1, Año 2021.En esta oportunidad, reivindica los aportes de sentidos que tiene una revista de educación como apuesta a pensar las cuestiones relevantes de la realidad educativa territorial, regional, nacional e internacional en relación con lo socio histórico cultural, lo político y lo académico científico. Cada uno de los artículos, desde diferentes perspectivas, aborda los problemas teóricos y didácticos del quehacer educativo, considerando sus tensiones, sus divergencias y tramas, como así también, los
Resistir desde el estado. La construcción de estrategias “desde abajo” frente a los modos de gestión de las políticas hacia la escuela secundaria obligatoria de cambiemos
Authors: Diyarian Maida , Rodriguez Moyano Inés
Published: November 2021

Este artículo analiza los modos de gestión que acompañan a los procesos de implementación de las políticas dirigidas a garantizar la obligatoriedad del nivel secundario en el marco de la restauración conservadora. A partir de un estudio de corte cualitativo, el presente trabajo analiza las miradas de los referentes de la gestión intermedia sobre la orientación de las políticas educativas durante el periodo 2015 - 2018 en la Provincia de Buenos Aires, así como las estrategias de resistencias a escala local para la ampliación del derecho a la educación.
Formación de profesionales en interacción con la localidad en el centro universitario municipal de Jagüey Grande, Cuba
Authors: Fariñas Barrios Edith Enélida , Pérez Cano Raquel , Pérez Sibila Adalberto
Published: November 2021

El vínculo universidad-sociedad demanda la calidad e integración de los procesos y funciones universitarias en correspondencia con la realidad social que garantice el egreso de profesionales integrales, con alta calificación en su desempeño profesional, comprometidos con la transformación, construcción y desarrollo de la sociedad. En los municipios este proceso reclama la relación bidireccional con las entidades locales, pudiendo estas últimas apropiarse de los conocimientos y saberes que aporta la academia en la misma medida que se perfecciona el proceso de formación. En el presente trabajo se presentan reflexiones sobre el comportamiento de la relación CUM-localidad en el proceso de formación de profesionales desde la fundación del Centro Universitario Municipal (CUM) de Jagüey Grande hasta la actualidad. Se presentan acciones dirigidas al perfeccionamiento del proceso de formación en interacción con la localidad y se esbozan algunos resultados enmarcados en tres períodos considerados para el estudio. Se emplearon métodos empíricos de análisis de documentos, encuesta y entrevista que posibilitaron la obtención de resultados sobre la temática de investigación.
Configuraciones de la formación docente inicial en Argentina (2015-2019): de las competencias a la fabricación de resultados
Authors: Piazzentino Raúl Enrique
Published: November 2021

Avanzada la primera década de los años dos mil hasta la actualidad, las políticas de formación docente en Argentina se configuran mediante la modalidad discursiva de Planes Nacionales de Formación Docente, representando una mudanza con relación a la formulación de planes de estudio y programas de formación de las últimas décadas del siglo XX.
En esta producción analizamos desde una perspectiva político discursiva, en línea con la Teoría de Discurso y el Análisis Político de Discurso, el Plan Nacional de Formación Docente 2015-2019, entre otros documentos y normativas oficiales del período. Este conjunto de textos se halla imbricado en el discurso de las políticas para la formación docente inicial, organizado en torno al significante privilegiado de las competencias profesionales en el currículo.
A partir del significante privilegiado, reconocemos el delineado de un dispositivo de fabricación de resultados que procura, por una parte, dar cuenta de una ineficiencia de la formación docente inicial vigente y, por otra, orienta la mejora de la eficiencia hacia la fijación de estándares basados en competencias profesionales. Desde los productos de este dispositivo podemos reconocer las trazas de un modelo de identificación desde el que se interpela a las distintas posiciones del sistema formador, en línea con tendencias de signo neoliberal de estandarización y eficientismo impuestas a nivel regional desde países hegemónicos.