bluuebunny/crossref_metadata_2025 huggingface dataset:
Agency, Politics, and the “Impossible Domestic”: A Response to Walter Johnson’s “On Agency”
Authors: Zimmerman Angela Elisabeth
Published: December 2023

Walter Johnson’s point about “agency” can be extended to other central concepts of historical analysis: what might appear as a salutary extension of a foundational category of liberal democracy to the histories of enslaved people in fact forces those histories into frameworks that are, ultimately, those of enslavers. The interconnected insights of Black feminism and Queer theory—particularly about “domestic institutions”—suggest that politics is another of those categories that, like agency, risks forcing the histories of enslaved people into analytic categories of an ultimately white-supremacist liberalism.
Regulation of the trade-off between cold stress and growth by glutathione S-transferase phi class 10 (BcGSTF10) in non-heading Chinese cabbage
Authors: Shen Yunlou , Wang Guangpeng , Ran Jiajun , Li Yiran , Wang Huiyu , Ding Qiang , Li Ying , Hou Xilin
Published: December 2023

Cold stress is a serious threat to global crop production and food security, but plant cold resistance is accompanied by reductions in growth and yield. In this study, we determined that the novel gene BcGSTF10 in non-heading Chinese cabbage [NHCC; Brassica campestris (syn. Brassica rapa) ssp. chinensis] is implicated in resistance to cold stress. Biochemical and genetic analyses demonstrated that BcGSTF10 interacts with BcICE1 to induce C-REPEAT BINDING FACTOR (CBF) genes that enhance freezing tolerance in NHCC and in Arabidopsis. However, BcCBF2 represses BcGSTF10 and the latter promotes growth in NHCC and Arabidopsis. This dual function of BcGSTF10 indicates its pivotal role in balancing cold stress and growth, and this important understanding has the potential to inform the future development of strategies to breed crops that are both climate-resilient and high-yielding.
Genetic engineering low-arsenic and low-cadmium rice grain
Authors: Gui Yuejing , Teo Joanne , Tian Dongsheng , Yin Zhongchao
Published: December 2023

Rice is prone to take up the toxic elements arsenic (As) and cadmium (Cd) from paddy soil through the transporters for other essential elements. Disruption of these essential transporters usually adversely affects the normal growth of rice and the homeostasis of essential elements. Here we report on developing low-As and low-Cd rice grain through the co-overexpression of OsPCS1, OsABCC1, and OsHMA3 genes under the control of the rice OsActin1 promoter. Co-overexpression of OsPCS1 and OsABCC1 synergistically decreased As concentration in the grain. Overexpression of OsPCS1 also decreased Cd concentration in the grain by restricting the xylem-to-phloem Cd transport in node I, but paradoxically caused Cd hypersensitivity as the overproduced phytochelatins in OsPCS1-overexpressing plants suppressed OsHMA3-dependent Cd sequestration in vacuoles and promoted Cd transport from root to shoot. Co-overexpression of OsHAM3 and OsPCS1 overcame this suppression and complemented the Cd hypersensitivity. Compared with non-transgenic rice control, co-overexpression of OsABCC1, OsPCS1, and OsHMA3 in rice decreased As and Cd concentrations in grain by 92.1% and 98%, respectively, without causing any defect in plant growth and reproduction or of mineral nutrients in grain. Our research provides an effective approach and useful genetic materials for developing low-As and low-Cd rice grain.
The divorce cooling-off period in China: implementation, effects, and improvements
Authors: Zhang Bowen , Zhang Xiaomei
Published: December 2023

In recent years, rash divorces have become increasingly common in China, largely due to the simplified divorce process by registration. To address this issue, based on the pilot programme in some regions of China and reference to beneficial overseas legislative experience, Article 1077 of the Civil Code of the People’s Republic of China (CCPRC) introduced a divorce cooling-off period. In this work, we conduct empirical analysis to reveal the effectiveness of this cooling-off period in curbing rash divorces. It is revealed that the new legislation has led to a reduction in both registered divorces and the crude divorce rate. Despite its success, we find that the cooling-off period implemented by the CCPRC has some drawbacks. These include the excessive restriction of divorce freedom, the failure of this period to maximize the deterrent effects on rash divorce, as well as occasional misuse to delay divorce. In this regard, the authors propose necessary revisions for further improvement.
A Descriptive Analysis of Blood Products Utilized by a Forward Deployed Surgical Team in Syria
Authors: Grimsley Bailey M , Mann-Salinas Elizabeth , Becker Tyson
Published: December 2023

Introduction

Traumatically injured combat casualties urgently need both blood and surgery. Forward Surgical Teams (FSTs) or Role 2 (R2) surgical teams were created to minimize the time-space distance from point of injury to damage control surgery. Our goal is to describe the use of blood products from a Split FST deployed to Green Village from July 2018 to April 2019.

Materials and Methods

A retrospective review of a collection of patients treated by a single R2 was conducted following institutional regulatory approval. De-identified data were input into the study database and were then retrospectively reviewed for patients who presented to and received treatment at the R2 facility.

Results

Of the 470 total patients treated in 10 months: 226 (48%) received blood products and 132 (28%) underwent operative procedures. The patients were 98% male; 74% Host Nationals (HN), 24% North American Treaty Organization members. Mechanism of injury was 75% explosive and 98% penetrating. Documented Injury Severity Scores (n = 214) were: <9 (n = 57/27%), 9 to 15 (n = 34/16%), 16 to 25 (n = 64/30%), and >25 (n = 59/28%). In total 1,052 units of blood products were administered: whole blood (n = 495), red blood cells (n = 200), fresh frozen plasma (n = 109), and liquid plasma (n = 248). HN whole blood used was 337/495 (68%) units for 78 patients; walking blood bank was mobilized six times for HN patients. Of the patients seen, >99% who arrived with a pulse survived to be discharged to a higher level of care.

Conclusions

This analysis describes blood usage associated with one high volume forward deployed operative team and demonstrates the vital importance of the R2 split FST to provide coalition forces with surgical care in proximity to the point of injury. Over time, the supply chain has improved with more component therapy available at R2s; however, the need for walking blood bank and innovative solutions to care for all casualties must be part of small team capabilities. Liquid plasma use should be expanded as soon as it is feasible.
Orbits and dynamical masses for the active Hyades multiple system HD 284163
Authors: Torres Guillermo , Schaefer Gail H , Stefanik Robert P , Latham David W , Jones Jeremy , Lanthermann Cyprien , Monnier John D , Kraus Stefan , Anugu Narsireddy , ten Brummelaar Theo , Chhabra Sorabh , Codron Isabelle , Ennis Jacob , Gardner Tyler , Gutierrez Mayra , Ibrahim Noura , Labdon Aaron , Mortimer Dan , Setterholm Benjamin R
Published: December 2023

We report near-infrared long-baseline interferometric observations of the Hyades multiple system HD 284163, made with the Center for High Angular Resolution Astronomy array, as well as almost 43 yr of high-resolution spectroscopic monitoring at the Center for Astrophysics. Both types of observations resolve the 2.39 d inner binary, and also an outer companion in a 43.1 yr orbit. Our observations, combined with others from the literature, allow us to solve for the 3D inner and outer orbits, which are found to be at nearly right angles to each other. We determine the dynamical masses of the three stars (good to better than 1.4 per cent for the inner pair), as well as the orbital parallax. The secondary component (0.5245 ± 0.0047 M⊙) is now the lowest mass star with a dynamical mass measurement in the cluster. A comparison of these measurements with current stellar evolution models for the age and metallicity of the Hyades shows good agreement. All three stars display significant levels of chromospheric activity, consistent with the classification of HD 284163 as an RS CVn object. We present evidence that a more distant fourth star is physically associated, making this a hierarchical quadruple system.
Stellar triples with chemically homogeneously evolving inner binaries
Authors: Dorozsmai Andris , Toonen Silvia , Vigna-Gómez Alejandro , de Mink Selma E , Kummer Floris
Published: December 2023

Observations suggest that massive stellar triples are common. However, their evolution is not yet fully understood. We investigate the evolution of hierarchical triples in which the stars of the inner binary experience chemically homogeneous evolution (CHE), particularly to understand the role of the tertiary star in the formation of gravitational-wave (GW) sources. We use the triple-star rapid population synthesis code tres to determine the evolution of these systems at two representative metallicities: Z = 0.005 and Z = 0.0005. About half of all triples harbouring a CHE inner binary (CHE triples) experience tertiary mass transfer (TMT) episodes, an event which is rare for classically evolving stars. In the majority of TMT episodes, the inner binary consists of two main-sequence stars (58–60 per  cent) or two black holes (BHs, 24–31 per cent). Additionally, we explore the role of von Zeipel-Lidov-Kozai (ZLK) oscillations for CHE triples. ZLK oscillations can result in eccentric stellar mergers or lead to the formation of eccentric compact binaries in systems with initial outer pericentre smaller than ∼ 1200 R⊙. Approximately 24–30 per cent of CHE triples form GW sources, and in 31 per cent of these, the tertiary star plays a significant role and leads to configurations that are not predicted for isolated binaries. We conclude that the evolution of CHE binaries can be affected by a close tertiary companion, resulting in astronomical transients such as BH–BH binaries that merge via GW emission orders of magnitude faster than their isolated binary counterparts and tertiary-driven massive stellar mergers.
TOI-544 b: a potential water-world inside the radius valley in a two-planet system
Authors: Osborne H L M , Van Eylen V , Goffo E , Gandolfi D , Nowak G , Persson C M , Livingston J , Weeks A , Pallé E , Luque R , Hellier C , Carleo I , Redfield S , Hirano T , Garbaccio Gili M , Alarcon J , Barragán O , Casasayas-Barris N , Díaz M R , Esposito M , Knudstrup E , Jenkins J S , Murgas F , Orell-Miquel J , Rodler F , Serrano L , Stangret M , Albrecht S H , Alqasim A , Cochran W D , Deeg H J , Fridlund M , Hatzes A P , Korth J , Lam K W F
Published: December 2023

We report on the precise radial velocity follow-up of TOI-544 (HD 290498), a bright K star (V = 10.8), which hosts a small transiting planet recently discovered by the Transiting Exoplanet Survey Satellite (TESS). We collected 122 high-resolution High Accuracy Radial velocity Planet Searcher (HARPS) and HARPS-N spectra to spectroscopically confirm the transiting planet and measure its mass. The nearly 3-yr baseline of our follow-up allowed us to unveil the presence of an additional, non-transiting, longer-period companion planet. We derived a radius and mass for the inner planet, TOI-544 b, of 2.018 ± 0.076 R⊕ and 2.89 ± 0.48 M⊕, respectively, which gives a bulk density of $1.93^{+0.30}_{-0.25}$ g cm−3. TOI-544 c has a minimum mass of 21.5 ± 2.0 M⊕ and orbital period of 50.1 ± 0.2 d. The low density of planet-b implies that it has either an Earth-like rocky core with a hydrogen atmosphere, or a composition which harbours a significant fraction of water. The composition interpretation is degenerate depending on the specific choice of planet interior models used. Additionally, TOI-544 b has an orbital period of 1.55 d and equilibrium temperature of 999 ± 14 K, placing it within the predicted location of the radius valley, where few planets are expected. TOI-544 b is a top target for future atmospheric observations, for example with JWST, which would enable better constraints of the planet composition.
Nebular emission from young stellar populations including binary stars
Authors: Lecroq Marie , Charlot Stéphane , Bressan Alessandro , Bruzual Gustavo , Costa Guglielmo , Iorio Giuliano , Spera Mario , Mapelli Michela , Chen Yang , Chevallard Jacopo , Dall’Amico Marco
Published: December 2023

We investigate the nebular emission produced by young stellar populations using the new galsevn model based on the combination of the sevn population-synthesis code including binary-star processes and the galaxev code for the spectral evolution of stellar populations. Photoionization calculations performed with the cloudy code confirm that accounting for binary-star processes strongly influences the predicted emission-line properties of young galaxies. In particular, we find that our model naturally reproduces the strong He ii λ4686/H β ratios commonly observed at high H β equivalent widths in metal-poor, actively star-forming galaxies, which have proven challenging to reproduce using previous models. Including bursty star formation histories broadens the agreement with observations, while the most extreme He ii λ1640 equivalent widths can be reproduced by models dominated by massive stars. galsevn also enables us to compute, for the first time in a way physically consistent with stellar emission, the emission from accretion discs of X-ray binaries (XRBs) and radiative shocks driven by stellar winds and supernova explosions. We find that these contributions are unlikely to prominently affect the predicted He ii λ4686/H β ratio, and that previous claims of a significant contribution by XRBs to the luminosities of high-ionization lines are based on models predicting improbably high ratios of X-ray luminosity to star formation rate, inconsistent with the observed average luminosity function of XRBs in nearby galaxies. The results presented here provide a solid basis for a more comprehensive investigation of the physical properties of observed galaxies with galsevn using Bayesian inference.
Biophysical and structural characterization of a multifunctional viral genome packaging motor
Authors: Prokhorov Nikolai S , Davis Christal R , Maruthi Kashyap , Yang Qin , Sherman Michael B , Woodson Michael , White Mark A , Miller Lohra M , Jarrold Martin F , Catalano Carlos E , Morais Marc C
Published: December 2023

The large dsDNA viruses replicate their DNA as concatemers consisting of multiple covalently linked genomes. Genome packaging is catalyzed by a terminase enzyme that excises individual genomes from concatemers and packages them into preassembled procapsids. These disparate tasks are catalyzed by terminase alternating between two distinct states—a stable nuclease that excises individual genomes and a dynamic motor that translocates DNA into the procapsid. It was proposed that bacteriophage λ terminase assembles as an anti-parallel dimer-of-dimers nuclease complex at the packaging initiation site. In contrast, all characterized packaging motors are composed of five terminase subunits bound to the procapsid in a parallel orientation. Here, we describe biophysical and structural characterization of the λ holoenzyme complex assembled in solution. Analytical ultracentrifugation, small angle X-ray scattering, and native mass spectrometry indicate that 5 subunits assemble a cone-shaped terminase complex. Classification of cryoEM images reveals starfish-like rings with skewed pentameric symmetry and one special subunit. We propose a model wherein nuclease domains of two subunits alternate between a dimeric head-to-head arrangement for genome maturation and a fully parallel arrangement during genome packaging. Given that genome packaging is strongly conserved in both prokaryotic and eukaryotic viruses, the results have broad biological implications.
A prophage encoded ribosomal RNA methyltransferase regulates the virulence of Shiga-toxin-producing Escherichia coli (STEC)
Authors: Gong Chen , Chakraborty Dolonchapa , Koudelka Gerald B
Published: December 2023

Shiga toxin (Stx) released by Shiga toxin producing Escherichia coli (STEC) causes life-threatening illness. Its production and release require induction of Stx-encoding prophage resident within the STEC genome. We identified two different STEC strains, PA2 and PA8, bearing Stx-encoding prophage whose sequences primarily differ by the position of an IS629 insertion element, yet differ in their abilities to kill eukaryotic cells and whose prophages differ in their spontaneous induction frequencies. The IS629 element in ϕPA2, disrupts an ORF predicted to encode a DNA adenine methyltransferase, whereas in ϕPA8, this element lies in an intergenic region. Introducing a plasmid expressing the methyltransferase gene product into ϕPA2 bearing-strains increases both the prophage spontaneous induction frequency and virulence to those exhibited by ϕPA8 bearing-strains. However, a plasmid bearing mutations predicted to disrupt the putative active site of the methyltransferase does not complement either of these defects. When complexed with a second protein, the methyltransferase holoenzyme preferentially uses 16S rRNA as a substrate. The second subunit is responsible for directing the preferential methylation of rRNA. Together these findings reveal a previously unrecognized role for rRNA methylation in regulating induction of Stx-encoding prophage.
The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity
Authors: Folco H Diego , Xiao Hua , Wheeler David , Feng Hanqiao , Bai Yawen , Grewal Shiv I S
Published: December 2023

Centromeric chromatin plays a crucial role in kinetochore assembly and chromosome segregation. Centromeres are specified through the loading of the histone H3 variant CENP-A by the conserved chaperone Scm3/HJURP. The N-terminus of Scm3/HJURP interacts with CENP-A, while the C-terminus facilitates centromere localization by interacting with the Mis18 holocomplex via a small domain, called the Mis16-binding domain (Mis16-BD) in fission yeast. Fungal Scm3 proteins contain an additional conserved cysteine-rich domain (CYS) of unknown function. Here, we find that CYS binds zinc in vitro and is essential for the localization and function of fission yeast Scm3. Disrupting CYS by deletion or introduction of point mutations within its zinc-binding motif prevents Scm3 centromere localization and compromises kinetochore integrity. Interestingly, CYS alone can localize to the centromere, albeit weakly, but its targeting is greatly enhanced when combined with Mis16-BD. Expressing a truncated protein containing both Mis16-BD and CYS, but lacking the CENP-A binding domain, causes toxicity and is accompanied by considerable chromosome missegregation and kinetochore loss. These effects can be mitigated by mutating the CYS zinc-binding motif. Collectively, our findings establish the essential role of the cysteine-rich domain in fungal Scm3 proteins and provide valuable insights into the mechanism of Scm3 centromere targeting.
Pandemic preparedness from the perspective of Occupational Health professionals
Authors: Chen Y , Ingram C , Downey V , Roe M , Sripaiboonkij P , Buckley C M , Alvarez E , Perrotta C , Buggy C
Published: December 2023

Background

Prior to any infectious disease emergence as a public health concern, early occupational preparedness is crucial for protecting employees from novel pathogens— coronavirus disease 2019 (COVID-19) is no different.

Aims

This study ascertains how occupational safety and health (OSH)/Human Resource (HR) professionals in the Republic of Ireland had managed to prepare their workplaces prior to the advent of COVID-19.

METHODS

As part of a larger COVID-19 workplace study, online focus groups were conducted with OSH/HR professionals. Collected data were transcribed verbatim and entered into NVivo for thematic analysis incorporating intercoder reliability testing.

RESULTS

Fifteen focus groups were conducted with OSH/HR professionals (n = 60) from various occupational settings. Three levels of organizational preparedness were identified: ‘early awareness and preparation’; ‘unaware and not ready’ and ‘aware, but not ready’. Most organizations were aware of the COVID-19 severity, but not fully prepared for the pandemic, especially stand-alone enterprises that may not have sufficient resources to cope with an unanticipated crisis. The experiences shared by OSH professionals illustrate their agility in applying risk management and control skills to unanticipated public/occupational health crises that arise.

Conclusions

General pandemic preparedness such as the availability of work-from-home policies, emergency scenario planning and prior experience in workplace outbreaks of infectious diseases were helpful for workplace-associated COVID-19 prevention. This is the first study conducted with OSH/HR professionals in Ireland regarding COVID-19 preparedness in workplaces, which provides valuable insights into research literature, as well as empirical experience for the preparation of future public health emergencies.
Impaired hospitalized patient mobility is associated with nurse injuries
Authors: McLaughlin K H , Young D L , Colantuoni E , Funk K , Stone A M , Ballreich J , Hoyer E H
Published: December 2023

Background

Staff injuries adversely affect the health of staff members as well the ability of health care teams to effectively care for patients. Identifying patients who pose an increased risk of injury may allow for the planning of risk mitigation strategies, but few studies have examined patient factors associated with staff injury risk.

Aims

Examine the relationship between staff injury and patient mobility, which has been linked to other key hospital outcomes.

Methods

Linking occupational health and electronic medical record data, we examined documented patient mobility levels, based on the Activity Measure for Post-Acute Care (AM-PAC) and the Johns Hopkins Highest Level of Mobility (JH-HLM) Scale, on the day prior to injury. In addition, we created a matched cohort of control patients not associated with staff injury to examine the influence of patient mobility on the odds of staff injury.

Results

We identified 199 staff injuries associated with 181 patients with 1063 matched controls. Patients had median scores of 11 and 3 on the AM-PAC and JH-HLM, respectively, indicating moderate–severe mobility impairments. In addition, scores in the lowest AM-PAC tertile (6–15) and lowest JH-HLM tertile (1–4) were associated with a 4.46-fold and 2.90-fold increase in the odds of nurse injury, respectively.

Conclusions

These results indicate that moderate–severe mobility impairments are associated with increased risk of nurse injury. Hospitals and clinical care teams should consider documenting mobility routinely and utilizing these values to identify patients who pose an increased risk of nurse injury.
How Veeries vary: Whole genome sequencing resolves genetic structure in a long-distance migratory bird
Authors: Kimmitt Abigail A , Pegan Teresa M , Jones Andrew W , Winker Kevin , Winger Benjamin M
Published: December 2023

In high-latitude species with high dispersal ability, such as long-distance migratory birds, populations are often assumed to exhibit little genetic structure due to high gene flow or recent postglacial expansion. We sequenced over 120 low-coverage whole genomes from across the breeding range of a long-distance migratory bird, the Veery (Catharus fuscescens), revealing strong evidence for isolation by distance. Additionally, we found distinct genetic structure between boreal, western montane U.S., and southern Appalachian sampling regions. We suggest that population genetic structure in this highly migratory species is detectable with the high resolution afforded by whole-genomic data because, similar to many migratory birds, the Veery exhibits high breeding-site fidelity, which likely limits gene flow. Resolution of isolation by distance across the breeding range was sufficient to assign likely breeding origins of individuals sampled in this species’ poorly understood South American nonbreeding range, demonstrating the potential to assess migratory connectivity in this species using genomic data. As the Veery’s breeding range extends across both historically glaciated and unglaciated regions in North America, we also evaluated whether contemporary patterns of structure and genetic diversity are consistent with historical population isolation in glacial refugia. We found that patterns of genetic diversity did not support southern montane regions (southern Appalachians or western U.S. mountains) as glacial refugia. Overall, our findings suggest that isolation by distance yields subtle associations between genetic structure and geography across the breeding range of this highly vagile species even in the absence of obvious historical vicariance or contemporary barriers to dispersal.
Transcription factor RhRAP2.4L orchestrates cell proliferation and expansion to control petal size in rose
Authors: Wang Yaru , Qin Meizhu , Zhang Guifang , Lu Jingyun , Zhang Chengkun , Ma Nan , Sun Xiaoming , Gao Junping
Published: December 2023

Maintaining proper flower size is vital for plant reproduction and adaption to the environment. Petal size is determined by spatiotemporally regulated cell proliferation and expansion. However, the mechanisms underlying the orchestration of cell proliferation and expansion during petal growth remains elusive. Here, we determined that the transition from cell proliferation to expansion involves a series of distinct and overlapping processes during rose (Rosa hybrida) petal growth. Changes in cytokinin content were associated with the transition from cell proliferation to expansion during petal growth. RNA sequencing identified the AP2/ERF transcription factor gene RELATED TO AP2 4-LIKE (RhRAP2.4L), whose expression pattern positively associated with cytokinin levels during rose petal development. Silencing RhRAP2.4L promoted the transition from cell proliferation to expansion and decreased petal size. RhRAP2.4L regulates cell proliferation by directly repressing the expression of KIP RELATED PROTEIN 2 (RhKRP2), encoding a cell cycle inhibitor. In addition, we also identified BIG PETALub (RhBPEub) as another direct target gene of RhRAP2.4L. Silencing RhBPEub decreased cell size, leading to reduced petal size. Furthermore, the cytokinin signaling protein ARABIDOPSIS RESPONSE REGULATOR 14 (RhARR14) activated RhRAP2.4L expression to inhibit the transition from cell proliferation to expansion, thereby regulating petal size. Our results demonstrate that RhRAP2.4L performs dual functions in orchestrating cell proliferation and expansion during petal growth.
Effects of historical inequity and institutional power on cannabis research: Moving toward equity and inclusion
Authors: Martin-Willett Renée , Stanger Madeline , James Wanda , Bryan Angela D , Bidwell L Cinnamon
Published: December 2023

Given historical inequities in cannabis laws and policies, there is an obligation on the part of researchers and policy makers to actively work toward improving equity in cannabis research at a time when the field is rapidly expanding. We wish to propose a way forward for cannabis research that acknowledges this history of discrimination and misuse of institutional power and embraces equity and inclusion. This article provides a brief perspective on historical drug policy, recent legalization trends that have disproportionately benefitted some groups over others, and the repercussions of those trends for the cannabis research enterprise. In addition, it proposes five key actions in both policy and research domains that are necessary to move the field of cannabis research, and perhaps biomedical research in substance use more broadly, forward in a productive and inclusionary way. Specifically, recommendations focus on equity-focused legislation and policy, supporting the entry and retention of scientists of color into the field, engaging in more ethical research practices, and practicing intentionally inclusive recruitment of participants will help to move the field of cannabis research forward. These efforts will ensure that scientific gains are shared equitably moving forward.
Russia's attacks on civilians strengthen Ukrainian resistance
Authors: Bartusevičius Henrikas , van Leeuwen Florian , Mazepus Honorata , Laustsen Lasse , Tollefsen Andreas Forø
Published: December 2023

The all-out Russian invasion of Ukraine commencing in February 2022 has been characterized by systematic violence against civilians. Presumably, the commanders of Russian forces believe that, for example, the bombing of residential buildings will force Ukrainians to lay down their arms. We ask whether military attacks against civilians deter or, in contrast, motivate resistance against the attackers. Two-wave probability surveys were collected in Ukraine in March and April 2022 (Ns = 1,081 and 811, respectively). Preregistered analyses indicate that perceptions and experience of military attacks (victimization) did not decrease Ukrainians’ motivations to resist the invading forces. The analyses suggest that victimization positively relates to motivations to join military combat in defense positions. Military attacks against civilians are morally impermissible and prohibited under international humanitarian law. Our results suggest that such attacks are also counterproductive from a military perspective.
The Asymmetric Polarization of Immigration Opinion in the United States
Authors: Ollerenshaw Trent , Jardina Ashley
Published: December 2023

In this paper, we analyze trends in Americans’ immigration attitudes and policy preferences nationally and across partisan and racial/ethnic groups. In the 1990s and early 2000s, Democrats and Republicans shared similarly negative attitudes toward immigrants and high levels of support for restrictionist immigration policies. Beginning in the 2010s and continuing through the early 2020s, however, Democrats’ aggregate immigration opinions liberalized considerably. We observed increasingly liberal immigration preferences among Democrats of all racial and ethnic backgrounds after 2016, but this trend was especially pronounced among white Democrats. Among Republicans, opinion on immigration remained mostly stable over this period, although in some cases it became more conservative (e.g., border security) and more liberal on others (e.g., amnesty). The marked liberalization in immigration opinion among Democrats has left partisans more divided on immigration than at any point since national surveys began consistently measuring immigration opinion in the late twentieth century.
National Origin Identity and Descriptive Representativeness: Understanding Preferences for Asian Candidates and Representation
Authors: Wu Jennifer D
Published: December 2023

This paper examines how an Asian candidate’s national origin background affects their perceived ability to represent different constituents. Would Asian voters prefer any Asian candidate over someone who is non-Asian? Using a series of survey experiments that randomly emphasize the national origin backgrounds of two real politicians and a hypothetical politician, I find that politicians who are East or Southeast Asian are viewed as more representative of Asian American interests than those who are South Asian. Nonetheless, respondents agree that Asian politicians, regardless of national origin, will represent Asian Americans more than a non-Asian politician. While national origin background matters, there is still potential for an electoral advantage based on shared Asian panethnicity. These results contribute to our understanding of the salience of panethnic identities in electoral contexts.
Exact WKB Analysis and TBA Equations for the Stark Effect
Authors: Ito Katsushi , Yang Jingjing
Published: December 2023

We apply the exact Wentzel–Kramers–Brillouin (WKB) analysis to a couple of 1D Schrödinger-type equations reduced from the Stark effect of hydrogen in a uniform electric field. By introducing Langer’s modification and incorporating the Stokes graphs, we prove the exactness of the Bohr–Sommerfeld quantization conditions for the Borel-resummed quantum WKB periods in the specific parameter regions of the electric field intensity and magnetic quantum number. It is also found these quantization conditions get modified with an additional suppressed contribution when the parameters vary beyond the specific regions. We also present thermodynamic Bethe ansatz (TBA) equations governing the quantum periods in the absence of Langer’s modification and discuss its wall-crossing and analytic continuation. Numerical calculations are conducted to compare the complex resonant frequencies from our quantization conditions against ones from the Riccati–Padé method; the TBA equations are also confirmed by comparing its expansions with all-order quantum periods.
Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures
Authors: Richards Ceri , Stevens Richard , Lix Lisa M , McCloskey Eugene V , Johansson Helena , Harvey Nicholas C , Kanis John A , Leslie William D
Published: December 2023

Objectives

FRAX uses clinical risk factors, with or without BMD, to calculate 10-year fracture risk. RA is a risk factor for osteoporotic fracture and a FRAX input variable. FRAX predates the current era of RA treatment. We examined how well FRAX predicts fracture in contemporary RA patients.

Methods

Administrative data from patients receiving BMD testing were linked to the Manitoba Population Health Research Data Repository. Observed cumulative 10-year major osteoporotic fracture (MOF) probability was compared with FRAX-predicted 10-year MOF probability with BMD for assessing calibration. MOF risk stratification was assessed using Cox regression.

Results

RA patients (n = 2099, 208 with incident MOF) and non-RA patients (n = 2099, with 165 incident MOF) were identified. For RA patients, FRAX-predicted 10-year risk was 13.2% and observed 10-year MOF risk was 13.2% (95% CI 11.6, 15.1). The slope of the calibration plot was 0.67 (95% CI 0.53, 0.81) in those with RA vs 0.98 (95% CI 0.61, 1.34) in non-RA patients. Risk was overestimated in RA patients with high FRAX scores (>20%), but FRAX was well calibrated in other groups. FRAX stratified risk in those with and without RA [hazard ratio (HR) 1.52 (95% CI 1.25, 1.72) vs 2.00 (95% CI 1.73, 2.31)], with slightly better performance in the latter (P for interaction = 0.004).

Conclusions

FRAX predicts fracture risk in contemporary RA patients but may slightly overestimate risk in those already at high predicted risk. Thus the current FRAX tool continues to be appropriate for fracture risk assessment in RA patients.
Fast Bayesian Inference of Phylogenies from Multiple Continuous Characters
Authors: Zhang Rong , Drummond Alexei J , Mendes Fábio K
Published: December 2023

Time-scaled phylogenetic trees are an ultimate goal of evolutionary biology and a necessary ingredient in comparative studies. The accumulation of genomic data has resolved the tree of life to a great extent, yet timing evolutionary events remain challenging if not impossible without external information such as fossil ages and morphological characters. Methods for incorporating morphology in tree estimation have lagged behind their molecular counterparts, especially in the case of continuous characters. Despite recent advances, such tools are still direly needed as we approach the limits of what molecules can teach us. Here, we implement a suite of state-of-the-art methods for leveraging continuous morphology in phylogenetics, and by conducting extensive simulation studies we thoroughly validate and explore our methods’ properties. While retaining model generality and scalability, we make it possible to estimate absolute and relative divergence times from multiple continuous characters while accounting for uncertainty. We compile and analyze one of the most data-type diverse data sets to date, comprised of contemporaneous and ancient molecular sequences, and discrete and continuous morphological characters from living and extinct Carnivora taxa. We conclude by synthesizing lessons about our method’s behavior, and suggest future research venues.
Trichoderma asperellum boosts nitrogen accumulation and photosynthetic capacity of wolfberry (Lycium chinense) under saline soil stress
Authors: Yan Kun , Zhu Mingye , Su Hongyan , Liu Xiao , Li Shuxin , Zhi Yibo , Li Yuxin , Zhang Jingdan
Published: December 2023

Trichoderma can promote plant growth under saline stress, but the mechanisms remain to be revealed. In this study, we investigate photosynthetic gas exchange, photosystem II (PSII) performance, nitrogen absorption and accumulation in a medicinal plant wolfberry (Lycium chinense) in saline soil supplemented with Trichoderma biofertilizer (TF). Larger nitrogen and biomass accumulation were found in plants supplemented with TF than with organic fertilizer (OF), suggesting that Trichoderma asperellum promoted plant growth and nitrogen accumulation under saline stress. T. asperellum strengthened root nitrogen (N) absorption according to greater increased root NH4+ and NO3− influxes under supplement with TF than OF, while nitrogen assimilative enzymes such as nitrate reductase, nitrite reductase and glutamine synthetase activities in roots and leaves were also stimulated. Thus, the elevated N accumulation derived from the induction of T. asperellum on nitrogen absorption and assimilation. Greater increased photosynthetic rate (Pn) and photosynthetic N-use efficiency under supplement with TF than OF illustrated that T. asperellum enhanced photosynthetic capacity and N utilization under saline stress. Although increased leaf stomatal conductance contributed to carbon (C) isotope fractionation under TF supplement, leaf 13C abundance was significantly increased by supplement with TF rather than OF, indicating that T. asperellum raised CO2 assimilation to a greater extent, reducing C isotope preference. Trichoderma asperellum optimized electron transport at PSII donor and acceptor sides under saline stress because of lower K and J steps in chlorophyll fluorescence transients under supplement with TF than OF. The amount of PSII active reaction centers was also increased by T. asperellum. Thus, PSII performance was upgraded, consistent with greater heightened delayed chlorophyll fluorescence transients and I1 peak under supplement with TF than OF. In summary, TF acted to increase N nutrient acquisition and photosynthetic C fixation resulting in enhanced wolfberry growth under saline soil stress.
Adaptive tails? Parallel evolution of expanded tails in monsoonal tropics lineages of an Australian gecko radiation (Oedura)
Authors: Green Amy L , Oliver Paul M , Gray Jaimi A , Sherratt Emma
Published: December 2023

Ecological drivers of variation in the morphology of the lizard tail are understudied despite its important and varied functions in defence, locomotion, balance, climbing, and resource storage. We quantified variation in original tail shape and surface area-to-volume ratio (SA : V) in an Australian gecko clade (Oedura) and tested whether environmental variables are predictors of this variation. To use museum specimens, we developed an approach to straighten deformed preserved tails for accurate shape analysis. Tail shape varied from a relatively ‘typical lizard’ tail—long, tapered, and circular in cross-section—to a distinctive expanded, wide, and flat shape. Extreme versions of the latter shape seem to have evolved in parallel in two distantly related lineages. Wide tails and low SA : V ratio values occur in the Australian Monsoonal Tropics, while arid zone species all had a narrow, tapered tail with high SA : V. These data suggest expanded or bulbous tails may be analogous to succulence in plants and an adaptation for resource storage in environments with predictable peaks (wet season) and dearths (dry season) of resource availability. However, limited replicated evolution of bulbous tails precludes statistical significance in this case, and more analyses of tail anatomy in Oedura and other lizard clades are required to test this hypothesis further.
Team-based care of the thoracic surgical patient
Authors: Slowey Charlie , Abernathy Jake
Published: December 2023

Purpose of review

Although team-based care has been shown in many sectors to improve outcomes, very little work has been done with the thoracic surgical patient. This review article focuses on this and, extrapolating from other closely related surgical fields, teamwork in thoracic surgery will be reviewed for outcome efficacy and substance.

Recent findings

The optimal team has been shown to display behaviors that allow them to model future needs, predict disaster, be adaptable to change, and promote team cohesiveness all with a positive effect on perioperative outcome. The suboptimal team will have transactional leadership, poor communication, ineffective conflict resolution, and hold rigid beliefs about other team members.

To improve outcome, the thoracic surgical team, centered on the anesthesiologist and surgeon, will display the ‘Big 5’ attributes of highly effective teams. There are attributes of poor teams, which the dyad should avoid in order to increase the team's function and thus outcome.
Innovative designs for trials informing the care of cardiac surgical patients: Part II
Authors: Anusic Nikola , Sessler Daniel I.
Published: December 2023

Purpose of review

This review examines advances in clinical trial methodologies relevant to cardiac anesthesia. It focuses on innovative approaches, including factorial randomization, composite outcomes, and cluster randomized trials, which enhance the efficiency, practical relevance, and generalizability of trial outcomes.

Recent findings

Factorial randomization is becoming popular because the approach allows investigators to simultaneously evaluate two or more interventions. Furthermore, factorial designs can evaluate interactions among treatments which is highly relevant information that cannot be obtained from separate trials. Composite outcomes are also increasingly utilized, combining multiple individual outcomes into a single measure, which increases statistical power and can better represent relevant physiology. Designing valid composites requires careful consideration of component outcome severity and incidence. Cluster randomized trials, including stepped wedge and multiple crossover designs, address the challenges of group-level effects and shared environments.

The evolution of clinical trial designs is marked by a shift towards methodologies that enhance efficiency and provide more nuanced insights into treatment effects. These include factorial designs for simultaneous intervention assessment, composite outcomes for comprehensive physiological representation, and cluster trials for group-level effect analysis. Such advancements are shaping the future of clinical research, making it more relevant, efficient, and broadly applicable.
Performance Characteristics of Sepsis Screening Tools During Delivery Admissions
Authors: Main Elliott K. , Fuller Matt , Kovacheva Vesela P. , Elkhateb Rania , Azar Kristen , Caldwell Morgan , Chiem Vanna , Foster Mindy , Gibbs Ronald , Hughes Brenna L. , Johnson Rebecca , Kottukapally Nobin , Cortes Magdalena Sanz , Rosenstein Melissa G. , Shields Laurence E. , Sudat Sylvia , Sutton Caitlin D. , Toledo Paloma , Traylor Austin , Wharton Kurt , Bauer Melissa E.
Published: December 2023

OBJECTIVE:

To evaluate the screening performance characteristics of existing tools for the diagnosis of sepsis during delivery admissions.

METHODS:

This was a case–control study using electronic health record data, including vital signs and laboratory results, for all delivery admissions of patients with sepsis from 59 nationally distributed hospitals. Patients with sepsis were matched by gestational age at delivery in a 1:4 ratio with patients without sepsis to create a comparison group. Patients with chorioamnionitis and sepsis were compared with a complete cohort of patients with chorioamnionitis without sepsis. Multiple screening criteria for sepsis were evaluated: the CMQCC (California Maternal Quality Care Collaborative), SIRS (Systemic Inflammatory Response Syndrome), the MEWC (the Maternal Early Warning Criteria), UKOSS (United Kingdom Obstetric Surveillance System), and the MEWT (Maternal Early Warning Trigger Tool). Sensitivity, false-positive rates, and C-statistics were reported for each screening tool. Analyses were stratified into cohort 1, which excluded patients with chorioamnionitis–endometritis, and cohort 2, which included those patients.

RESULTS:

Delivery admissions at 59 hospitals were extracted for patients with sepsis. Cohort 1 comprised 647 patients with sepsis, including 228 with end-organ injury, matched with a control group of 2,588 patients without sepsis. Cohort 2 comprised 14,591 patients with chorioamnionitis–endometritis, of whom 1,049 had sepsis and 238 had end-organ injury. In cohort 1, the CMQCC and the UKOSS pregnancy-adjusted criteria had the lowest false-positive rates (6.9% and 9.6%, respectively) and the highest C-statistics (0.92 and 0.91, respectively). Although other screening criteria, such as SIRS and the MEWC, had similar sensitivities, it was at the cost of much higher false-positive rates (21.3% and 38.3%, respectively). In cohort 2, including all patients with chorioamnionitis–endometritis, the highest C-statistics were again for the CMQCC (0.67) and UKOSS (0.64). All screening tools had high false-positive rates, but the false-positive rates for the CMQCC and UKOSS were substantially lower than those for SIRS and the MEWC.

CONCLUSION:

During delivery admissions, the CMQCC and UKOSS pregnancy-adjusted screening criteria have the lowest false-positive results while maintaining greater than 90% sensitivity rates. Performance of all screening tools was degraded in the setting of chorioamnionitis–endometritis.
Wideband Absorbance Predicts the Severity of Conductive Hearing Loss in Children With Otitis Media With Effusion
Authors: Aithal Sreedevi , Aithal Venkatesh , Kei Joseph
Published: December 2023

Objectives:

The objectives of the present study were to investigate the relationship between wideband absorbance (WBA) and air–bone gap (ABG) in children with a conductive hearing loss (CHL) due to otitis media with effusion (OME) and determine the accuracy of WBA to predict the magnitude of ABGs.

Design:

This was a prospective, cross-sectional study involving a control group of 170 healthy ears from 130 children (mean age 7.7 years) and a CHL cohort of 181 ears from 176 children (mean age 5.9 years) with OME. The CHL cohort was divided into three groups: CHL1, CHL2, and CHL3 defined by mean ABG (averaged across 0.5 to 4 kHz) of 16 to 25 dB, 26 to 35 dB, and 36 to 45 dB, respectively. WBA was measured at frequencies from 0.25 to 8 kHz at ambient pressure.

Results:

WBA was significantly reduced between 0.25 and 5 kHz for all CHL groups. The difference in WBA at 1 to 4 kHz between the control and CHL groups increased with increasing ABG. The predictive accuracy, as indicated by area under the receiver operating characteristic curve (AUROC) of WBA, increased with increasing ABG. The AUROC for WBA at 1.5 kHz was 0.86 for the CHL1, 0.91 for the CHL2, and 0.93 for the CHL3 group. The AUROCs for WBA averaged across 0.5 to 4 kHz were 0.88, 0.93, and 0.94 for the CHL1, CHL2, and CHL3 groups, respectively. Linear regression analyses showed significant negative correlations between WBA0.5–4 kand ABG0.5–4 k. The regression model (ABG0.5–4 k= 31.83 – 24.08 × WBA0.5–4 k) showed that WBA0.5–4 kpredicted ABG0.5–4 kwith high accuracy. Comparison of predicted and actual WBA on a different group of subjects revealed that at an individual level, the model predicted ABG between 16 and 35 with greater precision.

Conclusions:

There were significant strong correlations between WBA and ABG such that WBA decreased with increasing ABG. WBA demonstrated good discrimination accuracy with AUROC exceeding 0.88 for the 0.5 to 4 kHz and 1 to 4 kHz frequency bands. The WBA test holds promise for determining the severity of CHL in children with OME.