bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Analysis of PIN Genes in Cultivated Peanuts (Arachis hypogaea L.): Identification, Subcellular location, Evolution, and Expression patterns
Authors: Bian Jianxin , Cui Yuanyuan , Li Jihua , Guan Yu , Tian Shuhua , Liu Xiaoqin
Published: July 2023

Background
Auxin is an important hormone in plants and the PIN-FORMED (PIN) genes are essential to auxin distribution in growth and developmental processes of plants. ​Peanut is an influential cash crop, but research into PIN genes in peanuts remains limited.​
Results
In this study, 27 PIN genes were identified in the genome of cultivated peanut, resolving into four subfamilies. Most of the PIN genes were predicted to be located in the plasma membrane and a subcellular location experiment confirmed the prediction. The gene structure, cis-elements in the promoter, and evolutionary relationships were elucidated, facilitating our understanding of peanut PINs and their evolution. In addition, the expression patterns of these PINs in various tissues were analyzed according to a previously published transcriptome dataset and qRT-PCR, which gave us a clear understanding of the temporal and spatial expression of PIN genes in different growth stages and different tissues. Expression during peanut pod development helps us to study geotropism of the peanut peg. Moreover, the gene network and gene ontology enrichment of these PINs were presented.
Conclusions
This study details a comprehensive analysis of PIN genes in cultivated peanuts and lays the foundation for subsequent studies of peanut gene function and phenotype.
Exploration of biomarkers for systemic lupus erythematosus by machine-learning analysis
Authors: Zhao Xingyun , Duan Lishuang , Cui Dawei , Xie Jue
Published: July 2023

Background
In recent years, research on the pathogenesis of systemic lupus erythematosus (SLE) has made great progress. However, the prognosis of the disease remains poor, and high sensitivity and accurate biomarkers are particularly important for the early diagnosis of SLE.
Methods
SLE patient information was acquired from three Gene Expression Omnibus (GEO) databases and used for differential gene expression analysis, such as weighted gene coexpression network (WGCNA) and functional enrichment analysis. Subsequently, three algorithms, random forest (RF), support vector machine-recursive feature elimination (SVM-REF) and least absolute shrinkage and selection operation (LASSO), were used to analyze the above key genes. Furthermore, the expression levels of the final core genes in peripheral blood from SLE patients were confirmed by real-time polymerase chain reaction (PCR) assay.
Results
Five core genes (ABCB1, CD247, DSC1, KIR2DL3 and MX2) were found in this study. Moreover, the nomogram model showed that the five optimal key genes had good reliability and validity, which were further confirmed by clinical samples from SLE patients. The receiver operating characteristic (ROC) curves of the five genes also revealed that they had critical roles in the pathogenesis of SLE.
Conclusion
Overall, five key genes were obtained and validated through machine-learning analysis of the databases, which might offer a new perspective for the molecular mechanism and potential therapeutic targets for SLE.
External validation of the VIGex gene-expression signature as a novel predictive biomarker for immune checkpoint treatment
Authors: Bedard Philippe , Hernando-Calvo Alberto , Yang Cindy , Vila-Casadesús Maria , Han Ming , Liu Amy , Berman Hal , Spreafico Anna , Razak Albiruni , Lheureux Stephanie , Hansen Aaron , Giacco Deborah Lo , Matito Judit , Pugh Trevor , Bratman Scott , Aleshin Alexey , Berche Roger , Saavedra Omar , Garralda Elena , Elston Sawako , Siu Lillian , Ohashi Pamela , Vivancos Ana
Published: July 2023

Immune gene expression signatures are emerging as potential biomarkers for immunotherapy. Yet, their limited predictive performance and complexity limit routine clinical implementation. VIGex is a 12-gene expression classifier developed in both nCounter (Nanostring) and RNA-Seq assays and analytically validated across laboratories. VIGex classifies tumor samples into Hot, Intermediate-Cold (I-Cold) and Cold subgroups. VIGex-Hot has been associated with better immunotherapy (IO) treatment outcomes. Here we investigated the performance of VIGex and other IO biomarkers in an independent dataset of patients treated with Pembrolizumab in the INSPIRE phase 2 clinical trial (NCT02644369). Patients with advanced solid tumors were treated with Pembrolizumab 200 mg IV every 3 weeks. Tumor RNA-seq data from baseline tumor samples were classified by the VIGex algorithm. Circulating tumor DNA (ctDNA) was measured at baseline and start of cycle 3 using the bespoke Signatera™ assay. VIGex-Hot was compared to VIGex Intermediate-Cold + Cold and 4 groups were defined based on the combination of VIGex subgroups and the change in ctDNA at cycle 3 from baseline (ΔctDNA). Seventy-six patients were enrolled including 16 ovarian, 12 breast, 12 head and neck cancers, 10 melanoma and 26 other tumor types. Objective response rate was 24% in VIGex-Hot and 10% in I-Cold/Cold. VIGex-Hot subgroup was associated with higher OS (HR: 0.43; p = 0.009) and PFS (HR: 0.49; p = 0.036) when included in a multivariable model adjusted for tumor type, tumor mutational burden (TMB) and PD-L1 immunohistochemistry. The addition of ΔctDNA improved the predictive performance of the baseline VIGex classification for both OS and PFS. Our data indicate that the addition of ΔctDNA to baseline VIGex may refine prediction for IO.
The medical school dean: Understanding the development of a leader through Self- Determination Theory
Authors: Alwazzan Lulu
Published: July 2023

How a dean develops in context is crucial for our understanding of medical school administration. Exploring deans’ leadership experience may enrich our understanding of how they emerge, enact, and remain in administration. This study explores essential components of individual development and learning as outlined by Self-Determination Theory; that is, how deans develop autonomy in leadership, competency to lead, and a sense of belonging to medical schools. Semi-structured interviews were conducted with medical school deans in Riyadh city, Saudi Arabia. Participants were invited via email. Informed consent was secured. Interviews were conducted virtually, audio-recorded and transcribed. Data were analyzed using framework analysis. Five participants took part in the study. Eight themes were identified and in direct relation to the research questions:1) Leader’s autonomy: Defining autonomy and role negotiation), 2) Leader’s competency in leadership: Experience of mastery, influence of resources, formal leadership programs, and achievement of organizational goals), and 3) Sense of belonging: Interpersonal relationships and personal fulfillment. This study provides insights on the development of leaders in medical education at the granular level. Investment in developing deans as leaders and their teams through professional development programs may instigate transformational change for individuals and the executive leadership team, and if attention is paid to the leader as learner-in-context.
Kinematic Interactions between a Human Musculoskeletal Model and a Lower Limb Exoskeleton
Authors: Varma VS , Rao RY , Budarapu PR , Pandit MK , Vundavilli PR
Published: July 2023

The requirement and applicability of exoskeletons for rehabilitation has been indicated by the amount of efforts invested in research across the world in the past decades. However, commercial exoskeletons are still expensive and limited by the need for adjusting the structure to the individual user. In this study, the human-exoskeleton interactions are explored by designing a lower limb exoskeleton with ten degrees of freedom: six actuated and four passive. Finite element analysis (FEA) of the structure is carried out to observe that the structural design is able to withstand the operating loads. Furthermore, the model is imported to Opensim software and connected with the human musculoskeletal model at the locations where both bodies would be connected in a real scenario, using braces and straps. The connections between the human and exoskele-ton models are modelled as six degrees of freedom joints with limits. Data of two subjects from an openly available gait data-set is used to carry out kinematic simulations. Comparison of five cases: human without an exoskeleton, human-exoskeleton combined, human-exoskeleton combined with locked hip adduction, human-exoskeleton combined with locked hip rotation, and human-exoskeleton combined with locked hip adduction and rotation, proved that the absence of degrees of freedom from the exoskeleton affects and restricts the motion of joints while trying to execute the same walking movement. The amount of movement at the interfaces is estimated by the simulation results. Therefore, a new approach for simulating humanex-oskeleton combined model is presented here.
Retreatment Rates and Postprocedural Complications are Higher than Expected after BPH Surgeries: A US Healthcare Claims and Utilization Study
Authors: Kaplan Steven , Kaufman Ronald , Mueller Tom , Elterman Dean , Chughtai Bilal , Rukstalis Daniel , Woo Henry , Roehrborn Claus
Published: July 2023

Background
Up to 50% of men over 50 and 80% over 80 are affected by BPH. Shared decision-making regarding BPH treatment options can benefit from an improved understanding of relative risks and benefits for various treatments.
Methods
Data for this longitudinal retrospective population-based cohort study were obtained from a random sample of US Medicare and commercial claims (IBM Watson MarketScan) and restricted to men undergoing BPH surgery (TURP, PVP, PUL, WVTT) from 2015 to 2021 across all sites of service. Retreatments included Holmium laser enucleation and index procedures. Main outcomes were rates of retreatment and procedural complications over 1y, identified via CPT and ICD-9/10CM codes. Considered were procedural complications ≥1d post-index treatment and retreatment for patients with ≥1y data. Univariate cumulative incidence estimates, cumulative proportion and log-rank tests justified inclusion for covariate adjustment in Cox proportional hazard models.
Results
43,147 men diagnosed with BPH underwent 22,629 TURP, 11,392 PVP, 7,529 PUL, and 1,597 WVTT. At 1-year post-index: PUL was associated with the lowest rate of complication (PUL 15%, TURP 17%; PVP 19%, ; WVTT 26%); retreatment rates were not different (TURP 5.3%, PVP 5.3%, PUL 5.9%, WVTT 6.2%). At 5yr post-index: retreatment was lowest for TURP (7.0%) and was not significantly different between PVP and PUL (8.9% and 11.6%, respectively).
Conclusions
The results suggest that within one year of BPH surgery, one-in-twenty patients may require retreatment regardless of treatment choice, and for some technologies as many as one-in-four may require treatment for a complication.
Oropharyngeal swelling following a ragweed sublingual immunotherapy
Authors: Lee Soomin , Yang Jim , Lee Erika
Published: July 2023

Background: Sublingual immunotherapy (SLIT) is widely accepted as a safe and effective treatment for allergic rhinitis. Despite severe local and systemic reactions following SLIT are reported to be rare, it is important for patients to be educated and monitored for potential risks throughout treatment. This report presents the first documented case of severe oropharyngeal swelling following SLIT, which necessitated epinephrine treatment and termination of therapy, representing a previously unreported severe local reaction.
Case Presentation: A 30-year-old man with a history of severe seasonal allergic rhinoconjunctivitis and shellfish allergy presented with severe allergic reaction to ragweed SLIT (Ragwitek). The patient had previously received grass subcutaneous immunotherapy and birch SLIT, both of which were well tolerated. On day 9 of Ragwitek SLIT, the patient experienced oropharyngeal swelling, dyspnea, and dysphagia within minutes following administration of therapy, which required epinephrine treatment to alleviate symptoms. The patient had also experienced upper respiratory tract infection symptoms a few days prior which may have exacerbated the severity of the reaction.
Conclusions: This case highlights an occurrence of a rare severe local reaction following SLIT and emphasizes the importance of patient education and close monitoring, especially in those presenting with recurrent local swelling following SLIT. In addition, counselling these patients about the potential risk of oropharyngeal swelling and consideration for prescribing an epinephrine autoinjector is recommended.
Real-world data of atezolizumab in patients with previously treated locally advanced or metastatic urothelial bladder cancer.
Authors: Acedo Rocío Díaz , BANQUERI MERCEDES GALVAN , CRIADO SILVIA ARTACHO , PARRA EVA MARIA FERNANDEZ , GALAN ROCIO JIMENEZ , SANCHEZ ANA ISABEL GAGO , POZO JUAN FRANCISCO MARIN , BAUTISTA MARIA JOSE MARTINEZ
Published: July 2023

Background
Clinical trials of atezolizumab for locally advanced or metastatic urothelial bladder cancer (mUBC) report controversial efficacy data. Moreover, real-world evidence regarding this use is limited.
Aim
We aimed to evaluate the effectiveness of atezolizumab in a real-world population with mUBC, to explore the effectiveness in relation to certain poor prognostic criteria such as performance status by Eastern Oncology Cooperative Group (ECOG), hemoglobin levels, and liver metastases, and to determine the safety profile of atezolizumab.
Methods
This multicenter, retrospective real-world study included previously treated mUBC patients who received atezolizumab. The primary endpoint was overall survival (OS). Furthermore, progression-free survival (PFS), the best response reached, and safety data were analyzed. A descriptive analysis was performed, while OS and PFS were estimated using the Kaplan-Meier method.
Results
185 patients (84.9% men, median age 69 years) were included. Median PFS was 4.8 months [95% confidence interval (CI) 3.6-6.0], and median OS was 20.0 months (95% CI 11.8–28.5), with an objective response rate of 28.1%. OS was higher for patients with ECOG 0–1 [24.5 months (95% CI 14.5–34.6) vs 5.2 (95% CI 4.4-6.0), p = 0.004]; and for patients without liver metastases [25.4 months (95% CI 16.2–34.6) vs 6.4 months (95% CI 4.0-8.1), p = 0.006]. Regarding hemoglobin levels, no survival differences were detected. Adverse events were reported in 55.1% of patients.
Conclusion
In a real-world population with previously treated mUBC, atezolizumab appears to provide a clinically relevant benefit, which is even greater for patients with ECOG 0–1 and those without liver metastases, maintaining an acceptable safety profile.
Long-term clinical outcomes of stereotactic radiotherapy for bilateral vestibular schwannomas in neurofibromatosis type 2 patients
Authors: Puataweepong Putipun , Dhanacha Mantana , Ruangkanchanasetr Rawee , Boonyawan Keeratikarn , Hansasuta Ake , Saetia Kriangsak , Yongvithisatid Pornpan
Published: July 2023

Purpose
The evidence for treating patients with neurofibromatosis 2-related vestibular schwannoma (VS-NF2) using hypofractionated stereotactic radiation therapy (HSRT) is limited. This study aimed to investigate clinical outcomes in patients with VS-NF2 treated with CyberKnife HSRT.
Methods
We retrospectively analyzed 25 NF2 patients with 48 VSs who were treated using CyberKnife HSRT at Ramathibodi Hospital from January 2009 to January 2020.
Results
Median follow-up was 98 months (range, 24–155). Median tumor volume was 2.3 cm3 (range, 0.04–28.3). Median prescribed dose was 18 Gy (range, 18–25) in three fractions (range, 3–5). The 5- and 10-year progression free survival rates were 87% and 80%, respectively. The 5- and 10-year hearing preservation rates were 59% and 35%, respectively. Three patients developed new symptoms associated with transient volume expansion after treatment: hydrocephalus in one, facial weakness in one, and ataxia in one. No patient developed worsening of trigeminal nerve function. No malignant transformation occurred.
Conclusions
CyberKnife HSRT demonstrated excellent long-term tumor control with a low non-auditory complication rate in patients with VS-NF2. However, preservation of hearing remains a major concern.
Metabolomic profiling of amino acids study reveals a distinct diagnostic model for Diabetic kidney disease
Authors: Wang Jiao , Zhou Chunyu , Zhang Qing , Liu Zhangsuo
Published: July 2023

Diabetic kidney disease (DKD), a highly prevalent complication of diabetes mellitus, is a major cause of mortality in patients. However, identifying circulatory markers to diagnose DKD requires a thorough understanding of the metabolic mechanisms of DKD. In this study, we performed ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to reveal altered metabolic profiles of amino acids (AAs) in patients with DKD. We found decreased plasma levels of histidine and valine, increased urine levels of proline, decreased urine levels of histidine and valine, and increased saliva levels of arginine in patients with DKD compared with the levels in patients with type 2 diabetes mellitus (T2DM) and in healthy controls. Our analyses of the key metabolites and metabolic enzymes involved in histidine and valine metabolism indicated that the AAs level alterations may be due to enhanced carnosine hydrolysis, decreased degradation of homocarnosine and anserine, enhanced histidine methylation, and systemic enhancement of valine metabolism in patients with DKD. Notably, we generated a distinct diagnostic model with an AUC of 0.957 and an accuracy up to 92.2% on the basis of the AA profiles in plasma, urine and saliva differing in patients with DKD using logistic regression and receiver operating characteristic analyses. In conclusion, our results suggest that altered AA metabolic profiles are associated with the progression of DKD. Our DKD diagnostic model on the basis of AA levels in plasma, urine, and saliva may provide a theoretical basis for innovative strategies to diagnose DKD that may replace cumbersome kidney biopsies.
Socioeconomic Status on Survival Outcomes in Patients with Colorectal Cancer: A Cross-sectional Study
Authors: Zhu Bin , Hu Fei-Hong , Jia Yi-Jie , Zhao Dan-Yan , Zhang Wan-Qing , Tang Wen , Hu Shi-Qi , Ge Meng-Wei , Du Wei , Shen Wang-Qin , Chen Hong-Lin
Published: July 2023

Background
Colorectal cancer (CRC) is widely acknowledged as a prevalent malignancy and the second most common cause of cancer-related mortality worldwide. The aim of this study was to examine the independent impact of Median Household Income (MHI) on prognosis and survival outcomes in patients with CRC.
Methods
Data from 17 cancer registries of the United States Surveillance, Epidemiology, and End Results program, with follow-up extended until November 2022 was analyzed. A Cox proportional hazards regression analysis was conducted to evaluate the influence of different levels of MHI on survival outcomes among patients with CRC. A total of 761,697 CRC patient records were retrieved from the SEER database.
Results
The Cox regression analysis results indicated that patients with higher MHI exhibited improved overall survival outcomes when compared to those with lower MHI (MMHI: HR = 0.925, 95% CI = 0.916–0.935, P < 0.001; HMHI: HR = 0.861, 95% CI = 0.851–0.870, P < 0.001). Regardless of the specific tumor location, gender, or treatment method, higher MHI is consistently linked to improved survival outcomes. However, this association was not found to be statistically significant among American Indian/Alaska Native (MMHI: P = 0.017; HMHI: P = 0.081), Asian or Pacific Islander (MMHI: P = 0.223; HMHI: P = 0.002) and unmarried or domestic partner patients (MMHI: P = 0.311; HMHI: P = 0.011).
Conclusion
These results emphasize the importance of considering socioeconomic factors, such as income level, in understanding and addressing disparities in survival outcomes of CRC patients.
Maternal Health Outcomes in the context of fragility: A Retrospective Study from Lebanon
Authors: Dimassi Hani , Alameddine Mohamad , Sabra Nadine , Arnaout Nour El , Harb Ranime , Hamadeh Randa , Kak Faysal El , Shanaa Abed , Mossi Marta Orozco , Saleh Shadi , AlArab Natally
Published: July 2023

Background and aims:
The Lebanese healthcare system faces multiple challenges including limited capacities, shortage of skilled professionals, and inadequate supplies, in addition to hosting a significant number of refugees. While subsidized services are available for pregnant women, representing the majority of the refugee population in Lebanon, suboptimal access to antenatal care (ANC) and increased maternal mortality rates are still observed, especially among socioeconomically disadvantaged populations. This study aimed to review the maternal health outcomes of disadvantaged Lebanese and refugee pregnant women seeking antenatal care services at primary healthcare centers (PHCs) in Lebanon.
Methods
A retrospective chart review was conducted at twenty PHCs in Lebanon, including Ministry of Public Health (MOPH) and United Nations Relief and Works Agency for Palestine refugees (UNRWA) facilities. Data was collected from medical charts of pregnant women who visited the centers between August 2018 and August 2020. Statistical analysis was performed to explore outcomes such as the number of ANC visits, delivery type, and onset of delivery, using bivariate and multivariable logistic regression models.
Results
In the study, 3977 medical charts were analyzed. A multivariate logistic regression analysis, revealed that suboptimal ANC visits were more common in the Beqaa region and among women with current abortion or C-section. Syrians had reduced odds of C-sections, and Beqaa, Mount Lebanon, and South Lebanon regions had reduced odds of abortion. Suboptimal ANC visits and history of C-section increased the odds of C-section and abortion in the current pregnancy. As for preterm onset, the study showed an increased likelihood for it to occur when being Palestinian, having current C-section delivery, experiencing previous preterm onset, and enduring complications at the time of delivery.
Conclusion
This study suggests the need for low-cost interventions aiming at enhancing access to ANC services, especially among pregnant women in fragile settings.
CGMega: Explainable Graph Neural Network Framework with Attention Mechanisms for Cancer Gene Module Dissection
Authors: Li Hao , Han Zebei , Sun Yu , Wang Fu , Hu Pengzhen , Ren Chao , Xu Xiang , Chen Hebing , Yang Yang , Bo Xiaochen
Published: July 2023

Cancer is rarely the straightforward consequence of an abnormality in a single gene, but rather reflects a complex interplay of many genes, represented as gene modules. Here, we leveraged the recent advances of model-agnostic interpretation approach and developed CGMega, an explainable and graph attention-based deep learning framework to perform cancer gene module dissection. CGMega outperforms current approaches in cancer gene prediction, and it provides a promising approach to integrate multi-omics information. We applied CGMega to breast cancer cell line and acute myeloid leukemia (AML) patients, and we uncovered the high-order gene module formed by ErbB family and tumor factors NRG1, PPM1A and DLG2. We identified 396 candidate AML genes, and observed the enrichment of either known AML genes or candidate AML genes in a single gene module. We also identified patient-specific AML genes and associated gene modules. Together, these results indicate that CGMega can be used to dissect cancer gene modules, and provide high-order mechanistic insights into cancer development and heterogeneity.
CTHRC1 promotes the progression of clear cell renal cell carcinoma via the PI3K/AKT/GSK3β signaling pathway
Authors: Xie Wei , Zhang Yuanfeng , Zhang Ronggui
Published: July 2023

CTHRC1 is a tumor-associated protein involved in the remodeling of solid tumor tissue and closely related to tumor development. The character of CTHRC1 in ccRCC is unknown.With the purpose of investigating its role in ccRCC, a variety of analytical methods were used in this study. RT-qPCR and WB experiments were used to measure CTHRC1 expression in ccRCC. CTHRC1 was knocked down in tumor cells using siRNA and verified by RT-qPCR and WB. The functions of CTHRC1 in ccRCC cells were studied by CCK8, EdU, Transwell, and wound healing assays. The results showed that the proliferation and metastasis capacity of ccRCC would be inhibited by knocking down CTHRC1. The effect of CTHRC1 on ccRCC was studied in vivo with a nude mouse tumor transplantation model. By a bioinformatics approach, we learned that CTHRC1 was abundantly expressed in ccRCC tissues and was closely related to the prognosis of ccRCC patients. The GSEA results showed that CTHRC1 may be associated with EMT, which is regulated by the pathway of PI3K/AKT/GSK3β in ccRCC. In conclusion, CTHRC1 may be a promising therapeutic target for ccRCC by mediating the PI3K/AKT/GSK3β pathway.
An Ancient Sung-Poem and Vehicle for Kabbalah: The Song of Songs in the Hebrew Bible
Authors: BUTT Aviva
Published: July 2023

The biblical poem entitled Shir Ha-Shirim (The Song of Songs) composed by Shlomo, the third King of the united tribes of Israel about 1,000 years before the Common Era was composed in Hebrew. However, it was also translated and sung by numerous bards in ancient Arabic dialects, as well as being translated to Kurmanji Kurdish. The King composed this poem to substantiate the primeval identity of his kingdom and its connection to the expanses leading up to Jerusalem and the mountain range surrounding Jerusalem. The poem’s underlying meaning leans on the King’s knowledge of the ancient science of Kabbalah. The eight chapters included in the Hebrew Bible as debated in the first century CE, and recorded by the mishnaic Sages of Tiberias in the second century CE, now constitute what we have on record of the Song of Songs. The external shell of the poem, the first chapter of which mentions apple-wine and love, and tribal ethics, symbolizes and reminds of the first moment of love’s intoxication and knowledge. The King is mentioned in the Qur’an as the prophet Suleimān and is known in English as King Solomon. This study ends with an original translation of the Song of Songs with Notes.
A Comprehensive Review of 5G Networks for Sustainable and Smart
Cities
Authors: Kumar Sunil , Vaid Varun , Thakur Garima
Published: July 2023

The transition from the first generation of technology, which only had an analog voice, to
the fifth generation, which also had connected gadgets, gave the technology a new structure and
changed how people used it. Fifth-generation wireless technology, often known as 5G, is on the
cusp of reaching its potential maximum data transfer rate with a peak data throughput of 20 gigabits
per second (Gbps) and a typical data transfer rate of more than 100 megabits per second (Mbps).
The Internet of Things serves as the cornerstone of the future, and it is projected that by 2025, individual
users will use 13 times the amount of data that we do at this time. Therefore, 5G is extremely
important and the main feature of the 2030 Sustainable Development Agenda, which was ratified by
all of the Member States of the United Nations in 2015, and is the 17 Sustainable Development
Goals (SDGs), which represent an urgent call to action for all nations. These goals are referred to
collectively as the "SDGs." This study intends to examine how 5G networks might serve as important
facilitators for achieving sustainability and meeting some of the 17 SDGs. This is further
highlighted by evaluating the sustainability metrics for 5G networks. Ultimately, this helps to
demonstrate that 5G networks are environmentally, socially, and economically responsible. This
study focuses on the five primary SDGs that are important for the growth of smart cities.
First Order Phase Transition in Ferromagnetic Semiconductors in External Electric and Magnetic Fields (by the example of La-=SUB=-1-x-=/SUB=-Ca-=SUB=-x-=/SUB=-MnO-=SUB=-3-=/SUB=-) (on the example of La-=SUB=-1-x-=/SUB=-Ca-=SUB=-x-=/SUB=-MnO-=SUB=-3-=/SUB=-)
Authors: Povzner A. A.  , Volkov A. G.  , Lopatko E.I.  , Zaitseva N. A.
Published: July 2023

It is shown that during a first-order phase transition in ferromagnetic semiconductors based on lanthanum manganites, along with the semiconductor phase of s-electrons, a phase arises with fluctuation short-range order associated with a change in the sign of the intermode interaction parameter in the system of d-electrons. The phase separation region is characterized by fluctuations of local magnetization depending on temperature and external magnetic field. In this case, the temperature of the first order phase transition, above which phase separation arises, is appreciably affected by double exchange. Due to self-heating, the phase separation is significantly affected by the electric field, which leads to N-shaped current-voltage characteristics. Using La1-xCaxMnO3 as an example, it is shown that the switching on of electric and magnetic fields during a first-order phase transition in ferromagnetic semiconductors is accompanied by the appearance of self-oscillations of the electric current and magnetization. Keywords: double exchange, electron fluctuations of spin and charge density, Anderson localization, self-oscillations.
User Retention and Engagement in the Digital-Based Diabetes Education and Self-Management for Ongoing and Newly Diagnosed (myDESMOND) Program: Descriptive Longitudinal Study
Authors: Barker Mary M , Chauhan Radhika , Davies Melanie J , Brough Christopher , Northern Alison , Stribling Bernie , Schreder Sally , Khunti Kamlesh , Hadjiconstantinou Michelle
Published: July 2023

Background

Digital health interventions have the potential to improve the physical and psychosocial health of people living with type 2 diabetes. However, research investigating the long-term (≥1 year) retention and engagement of users within these programs is limited.

Objective

The aim of this study was to evaluate long-term user retention and engagement in the digital-based Diabetes Education and Self-Management for Ongoing and Newly Diagnosed (myDESMOND) program, using real-world data.

Methods

Anonymized data from all myDESMOND users who registered with the program on or before November 16, 2020, were included in the analyses. User retention was defined as the period between the day a user registered with the myDESMOND program and their last day of access. The primary engagement outcome was defined as the total number of log-ins to the program per user. The associations between retention, engagement, and sociodemographic factors (age, sex, and ethnicity) were tested using Cox regression models and Wilcoxon rank sum tests.

Results

A total of 9522 myDESMOND users were included in this analysis. Of the 9522 users, 5360 (56.29%) remained on the program for at least a month, whereas 1676 (17.6%) remained on the program for at least 1 year. Retention was significantly higher among older users; the adjusted hazard ratio (representing the risk of users leaving the program within the first year) among users aged ≥50 years, compared with those aged <50 years, was 0.79 (95% CI 0.75-0.84; P<.001). The median number of myDESMOND log-ins per user was 8 (IQR 4-8); however, this was significantly lower among users aged <50 years (P<.001). Engagement metrics also differed according to sociodemographic characteristics; the estimated time spent per log-in was 5.35 (IQR 2.22-11.80) minutes among all users; however, this was significantly higher among female users (P<.001), users aged ≥50 years (P<.001), and users of White ethnicity (P=.02).

Conclusions

Although retention and engagement of users within myDESMOND were found to be high, these findings highlight the need for age- and culture-specific implementation strategies and content adaptations to improve retention and engagement among all users of self-management programs.
COMPETITIVENESS OF BUSINESS MODELS OF AVIATION ENTERPRISES: INNOVATIVE ASPECT
Authors: Maslak Olha , Kolomytseva Olena , Hryshko Natalia , Yakovenko Yaroslava
Published: July 2023

The paper is devoted to the principles of business modelling of aviation enterprises. The methodological bases of the formation of the business model of aviation enterprises are considered and generalized. It is established that the methodology is based on a general and special set of methods and principles of scientific knowledge that ensure its applicability, the method of systems thinking in particular. It is also found out that the innovative transformation of the existing business model of the aviation enterprise requires its revision according to the following main parameters: value proposition, customers and customer orientation, interaction with other stakeholders, the profitability of the model. Based on the systems approach, it is proposed to use feedback diagrams and causal loop diagrams as an effective method of displaying the relationship of the elements of a system (an aviation enterprise) and understanding of their dynamic complexity. Examples of successfully implemented airline business models to provide competitive advantages through innovative management approaches have been presented and described. A number of factors that influence the formation of the business model as a tool to ensure the competitiveness of the aviation enterprise in the air services market are also identified. It is also proved that it is important to adhere to the principle of internal coherence, which involves forecasting of possible changes and confrontations in the business environment in order to correct the innovative business model regardless of the chosen adaptation strategy. Based on the study of foreign experience of business modelling, the authors substantiate practical recommendations for the iterative implementation of innovative business models at aviation enterprises. Prospects for further research are the study of laws and patterns on which the methodological principles of business modelling of aviation enterprises are based.
TAX BURDEN AS AN INDICATOR OF THE EFFICIENCY OF THE TAX SYSTEM IN UKRAINE
Authors: Gavrylenko V. O. , Demydenko S. L.
Published: July 2023

The article defines the essence of taxes as the main source of the revenue part of the country's budget. The meaning and purpose of the tax burden are revealed. It is proved that the efficiency of the tax system depends on the structure of tax revenues and the overall level of the tax load on the economy. The structure of tax revenues and other revenue items of the consolidated budget of Ukraine for 2017-2022 is analyzed. The results of the analysis show that tax revenues and their share in revenues decreased in 2022, correspondingly there were changes in the specific weight of individual taxes and fees.

The assessment of the tax burden in Ukraine in various ways shows a significant difference between the values of the general level of the tax burden and the level without taking into account the single social contribution. It is determined that, in addition to national and local taxes and fees, the receipt of a single contribution to mandatory state social insurance has a significant impact on the overall level of the tax burden.

The results of a comparison of the tax burden in Ukraine and the countries of the European Union show that in our country its value is at a low level. It is proven that the differences between countries with a high and low level of tax burden are determined by the economic policy of each country regarding public expenditures and tax structures.

In order to assess the efficiency of the tax system of Ukraine, a comparative analysis of indicators of the ease of paying taxes with similar indicators of EU countries has been carried out. The results of the analysis show that the tax system in Ukraine is quite complex, in particular, in terms of preparing and submitting tax returns, which makes doing business difficult.

The main priorities for ensuring the optimal level of the tax burden in Ukraine, such as: increase of the efficiency of tax administration, neutralization of negative impact on doing business, study of the European experience of transforming tax systems, have been determined.
THE ABILITY OF HIGHER EDUCATION SYSTEM OF UKRAINE TO PROVIDE PERSONNEL NEEDS OF THE NATIONAL RENEWABLE ENERGY INDUSTRY
Authors: Zakharova O.V.
Published: July 2023

The study made it possible to establish that the current state of training specialists in the field of renewable energy will not allow in the near future to quickly achieve the goals of intensive development of renewable energy proclaimed by the country's leadership. This will not improve the energy security of the regions and the country as a whole. This conclusion is based on the fact that, firstly, the training of specialists in Ukraine in educational programs on renewable energy is carried out by a limited number of higher education institutions, a significant number of which are accredited only by mid-2024. Secondly, the number of applicants operating in the current educational mastered this specialty in all years of study is not high. This will make it possible to rejuvenate the staff of workers serving existing renewable energy facilities. However, it will not allow to achieve the rapid development of projects for the introduction and use of alternative energy sources in the country. The work systematizes the markers of success, the focus on which by the guarantors of educational programs on renewable energy will improve the quality of educational services and interest applicants. These markers define the highly professional staff of teachers in the framework of educational programs; provision of the educational process of the educational program with certified laboratories with high-tech equipment; the availability of double degree programs in the specialty of the world's leading universities and international mobility programs; conducting joint scientific research with foreign scientists; introduction of a practice-oriented approach to learning.

The most effective directions for increasing the number of highly qualified profile specialists in renewable energy in the labor market of Ukraine in the post-war period are formulated. These areas were recognized as increasing the level of wages in the field of renewable energy; ensuring a high level of investment for the development of human capital in renewable energy enterprises; expanding opportunities for professional development in the industry; improving the quality of existing and opening new educational programs for training specialists in renewable energy; providing a full cycle of training specialized professionals on the basis of the country's leading institutions; increase in public opinion the prestige of the entire spectrum of professions related to renewable energy. This should allow solving the rather painful problem of energy security for Ukraine.
PRETRATAMIENTO CON CAMPO MAGNÉTICO EN LA FERMENTACIÓN DE EMULSIONES DE CARNE DE CERDO
Authors: Gelvez Ordoñez Víctor Manuel , Rolón Moreno Ana Milena , Caballero Pérez Luz Alba
Published: July 2023

La demanda de alimentos inocuos, mínimamente procesados y saludables por parte de los consumidores ha generado la necesidad de desarrollar nuevas tecnologías para cubrir dichas necesidades, estas deben ser sostenibles con el medio ambiente, por lo tanto, el objetivo de este trabajo fue evaluar el efecto del pretratamiento con Campo Magnético Estático- CME en la fermentación de emulsiones de carne de cerdo. Se preparó una emulsión %P/P con 15,03% proteína, 24,64% grasa, 57,64% agua, 1,90% sal, 0,02% nitrito, 0,1% cultivo y 0,67% lactosa. Se sometió a tratamiento con CME de 4,5mT durante 0, 3, 5 y 10 minutos. Posteriormente las muestras
 
 
fueron almacenadas durante 20 días a temperatura ambiente. Se evaluó el pH, color, estabilidad y humedad durante los días 1, 4, 8, 12, 16 y 20 y la microbiota se analizó el día 1 y 20. Se encontró que la emulsión es estable y su humedad no varía. El pH no varía con el pretratamiento, pero sí disminuye con el tiempo de almacenamiento. La actividad microbiana de Lactobacillus bulgaricus se ve afectada por el pretratamiento, pero exhibe una recuperación a los 4 días de almacenamiento. La luminosidad disminuye con el pretratamiento este efecto se mantiene hasta el día 4. En el parámetro a* del color el pretratamiento causa aumento en la escala, este cambio resulta proporcional al tiempo de tratamiento. El parámetro b* presenta disminución hasta el día 8 y posteriormente exhibe el comportamiento contrario. Estos cambios están relacionados con el tiempo del tratamiento. Se presentan reducciones de los coliformes totales a 200UFC/g y coliformes fecales a <3UFC/g en las muestras, por efecto de las condiciones de almacenamiento.
DAMPAK PENGGUNAAN GADGET PADA PERKEMBANGAN EMOSIONAL DAN KOGNITIF SISWA KELAS IV SEKOLAH DASAR
Authors: Afidah Sofiana Nur , Fakhriyah Fina , Oktavianti Ika
Published: July 2023

Abstrak : Penggunaan gadget merupakan kebutuhan penting bagi kehidupan saat ini. Namun penggunaan gadget yang berlebihan membuat perkembangan emosi dan kognitif siswa berubah. Tujuan penelitian untuk mengetahui bentuk dan dampak penggunaan gadget pada siswa kelas IV di Desa Tambahagung Kecamatan Tambakromo serta bentuk pendampingan orang tua terhadap perkembangan emosi dan kognitif anak. Gadget adalah perangkat mekanis yang terus diperbarui dan berguna untuk membantu memudahkan aktivitas manusia. Perkembangan emosi merupakan perkembangan yang timbul dan berkaitan dengan kebutuhan, tujuan, dan minat individu. Perkembangan kognitif adalah proses pertumbuhan berpikir logis dari bayi hingga dewasa. Jenis penelitian kualitatif dengan pendekatan studi kasus. Informan penelitian adalah 6 siswa kelas IV di desa Tambahagung. Teknik pengumpulan data adalah observasi, wawancara, dokumentasi, dan pencatatan. Analisis data meliputi penjodohan pola, pembuatan eksplanasi dan analisis deret waktu. Hasil penelitian adalah dampak penggunaan gadget dalam mempengaruhi perkembangan kognitif, yaitu dampak positif siswa kelas IV mampu mengeksplorasi pengetahuan lebih luas. Dampak negatifnya, jika bermain gadget secara berlebihan menyebabkan gangguan kesehatan dan menurunkan konsentrasi belajar. Bentuk pendampingan orang tua dalam penggunaan gadget pada anak yaitu dengan memberikan batasan dalam penggunaan, memberikan pengawasan, tanggung jawab penggunaan, dan selalu melakukan interaksi sosial agar anak tidak memiliki sikap acuh tak acuh.Kata Kunci: Penggunaan Gadget, Perkembangan Emosional, Perkembangan Kognitif.
TIPOLOGI PAHAM KEAGAMAAN MAHASISWA FAKULTAS ILMU KEOLAHRAGAAN UNIVERSITAS NEGERI MAKASSAR
Authors: Amri Rahman
Published: July 2023

Penelitian ini bertujuan untuk mengetahui tipologi pemahaman keagamaan mahasiswa FIK UNM melalui model kajian keagamaan yang diikuti mahasiswa FIK UNM dan pandangan mereka terhadap isu-isu keagamaan. Jenis penelitian yang digunakan pada penelitian ini yakni penelitian kualitatif dengan menggunakan pendekatan deskriptif. Penelitian ini menggunakan teknik purposive random sampling, yaitu teknik penentuan sampel dengan pertimbangan tertentu, selanjutnya dirandom, maka yang menjadi sampel dalam penelitian ini adalah mahasiswa aktif maupun tidak aktif dalam kelompok kajian keagamaan di Fakultas Ilmu Keolahragaan. Adapun teknik pengumpulan data yang dilakukan dalam penelitian ini adalah observasi, wawancara dan dokumentasi dengan teknik analisis data yang digunakan adalah teknik analisis data kualitatif deskriptif.  Hasil penelitian menunjukkan bahwa tipologi pemahaman keagamaan mahasiswa FIK UNM secara umum dapat diklasifikasi ke dalam 3 (tiga) tipe, yaitu inklusif, ekslusif dan moderat, tetapi pada umumnya mahasiswa memiliki pemahaman keagamaan yang bersifat moderat. Sikap moderasi tersebut tampak dari model kajian keagamaan yang diikuti oleh mahasiswa  yaitu arriyadhoh yang memiliki model kajian yang bersifat moderat. Moderasi beragama mahasiswa FIK UNM tampak juga dari pandangan mereka terhadap isu-isu keagamaan yang diperdebatkan oleh ulama. Mahasiswa FIK UNM welcome terhadap perbedaan pendapat, sehingga mereka tidak memiliki sikap fanatisme terhadap satu pendapat dan tidak pula menyalahkan pendapat yang lain.
An Installation Angle Error Calibration Method in an Ultra-Short Baseline System Based on a Dual Transponder
Authors: Liu Baoheng , Zhang Xiaochuan , Jia Shuyang , Zou Sichen , Tian Deyan , Da Lianglong
Published: July 2023

The installation error of an acoustic transceiver array is one of the important error sources in an ultra-short baseline (USBL) system. In a USBL system with a positioning accuracy of 0.5%, an installation error angle of 1° will lead to a positioning error of 1.7% times the slant distance. In this paper, a dual transponder-based installation angle error calibration method for USBL is proposed. First, the positioning errors induced by various installation angles are deduced and analysed using the linear measurement of seafloor targets. Then, an iterative algorithm is proposed that estimates the rolling alignment error, pitching alignment error, and heading alignment error, in that order. The simulation and experienced results show that, after three iterations, the estimates of the three alignment errors can converge quickly, all of the estimates converge to within 0.001° and the estimated values are very close to the true values. The horizontal positioning error caused by the installation error angle can be reduced by nearly 75%. The method has good effectiveness and robustness, and can greatly improve the positioning accuracy of the USBL system.
Comments on Existing Analytical Solutions to the Wave-Induced Cyclic Response of a Porous Seabed of Infinite Thickness
Authors: Magda Waldemar
Published: July 2023

This paper deals with the wave-induced cyclic response of a porous seabed (by means of oscillating parameters: pore-fluid pressure, soil displacement components, effective normal stress and shear stress components) due to a surface sinusoidal water-wave propagating over a seabed of infinite thickness. The main existing analytical solutions to the governing problem are critically discussed, pointing out their meaningful errors and doubtful items. A phase-lag phenomena is particularly studied as an immanent part of any complex-valued analytical solutions having a cyclic nature.
A prevalência de sintomas de ansiedade em acadêmicos de medicina
Authors: Moura Sasha Vilasboas , Cerqueira Neto José Domingos , Cardoso Felipe Márcio Lédo , Arcanjo Thiago Borges
Published: July 2023

Objetivo: Determinar a prevalência de sintomas de ansiedade entre os acadêmicos do curso de Medicina de uma instituição privada da Região Oeste da Bahia, determinar os principais fatores desencadeadores de ansiedade nos acadêmicos de Medicina e identificar os fatores associados aos níveis de ansiedade em estudantes de Medicina mais citados na literatura. Métodos: Trata-se de um estudo de caráter quantitativo, do tipo transversal, de natureza exploratória com levantamento e correlação de dados. Resultados: Em relação à distribuição dos sintomas de ansiedade, verificou-se que 55,5% afirmaram a presença desse sintoma minimamente ou, até mesmo, ausente, 19,1% apresentaram levemente, sem incomodar, 13,66% apresentaram de forma moderada, porém dava para suportar, enquanto 11,9% dificilmente conseguem suportar tais sintomas. Conclusão: A realização deste estudo revelou que o aparecimento da ansiedade é devido a elevada cobrança a que os acadêmicos do curso médico estão sujeitos desde a graduação médica, assim como a grande carga horária e a competitividade de terem notas melhores que os colegas. Observou-se que a maior prevalência de ansiedade, no presente estudo, foi de estudantes do sexo feminino e como sintomas mais prevalentes identificados foram sentir-se nervoso, medo de acontecer o pior e medo de perder o controle.