bluuebunny/crossref_metadata_2025 huggingface dataset:
A Distributed Feature Selection Pipeline for Survival Analysis using Radiomics in Non-Small Cell Lung Cancer Patients
Authors: Gottardelli Benedetta , Gouthamchand Varsha , Masciocchi Carlotta , Boldrini Luca , Martino Antonella , Mazzarella Ciro , Massaccesi Mariangela , Monshouwer René , Findhammer Jeroen , Wee Leonard , Dekker Andre , Gambacorta Maria Antonietta , Damiani Andrea
Published: December 2023

Predictive modelling of cancer outcomes using radiomics faces dimensionality problems and data limitations, as radiomics features often number in the hundreds, and multi-institutional data sharing is often unfeasible. Federated learning (FL) and feature selection (FS) techniques combined can help overcome these issues, as one provides the means of training models without exchanging sensitive data, while the other identifies the most informative features, reduces overfitting, and improves model interpretability. Our proposed FS pipeline based on FL principles targets data-driven radiomics FS in a multivariate survival study of non-small cell lung cancer patients. The pipeline was run across datasets from three institutions without patient-level data exchange. It includes two FS techniques, Correlation-based Feature Selection and LASSO regularization, and Cox Proportional-Hazard regression with Overall Survival as endpoint. Trained and validated on 828 patients overall, our pipeline yielded a radiomic signature comprising "intensity-based energy" and "mean discretised intensity". Validation resulted in a mean Harrell C-index of 0.59, showcasing fair efficacy in risk stratification. In conclusion, we propose an approach for distributed radiomics involving preliminary FS to reduce the available feature set to the most important on a data-driven basis and reduce dimensionality problems other than those related to data limitations and interpretability.
Extraction Rates of Algorithmically Random Continuous Functionals
Authors: Cenzer Douglas , Fraize Cameron , Porter Christopher
Published: December 2023

In this article, we study the extraction rate, or output/input rate, of continuous functionals on the Cantor space 2ω, in particular for algorithmically random functionals. It is shown that random functionals have an average extraction rate over all inputs corresponding to the rate of producing a single bit of output, and that this average rate is attained for any sufficiently random input. We also examine functions computed by discrete distribution generating trees, where we calculate the expected extraction rate and show that this rate is attained for any sufficiently random input.
Do we need a ban on firecrackers? Explosion injuries to hands caused by pyrotechnic objects during the turn of the year in Berlin/Brandenburg
Authors: Eichenauer Frank , Pandura Stefan , Kim Simon , Ekkernkamp Axel , Eisenschenk Andreas , Weber Stefan
Published: December 2023

Introduction: Fireworks carry a high risk for hand injuries.
Methods: The study presents data of 146 patients hospitalized with hand injuries caused by fireworks during the turn of the years 2005 to 2023. Statistical data presented include number, age and sex, injury patterns and concomitant injuries.
Results: The number of injured increased over the years with a significant increase in 2016 and incision during the COVID pandemic. Those affected were predominantly male. The age group between 19 and 36 years was the most represented, followed by elders between 37 and 65 years. Children and adolescents under 18 were affected in one-third of cases. Injury patterns included combinations of soft tissue lesions, open fractures and finger amputations. Concomitant injuries predominantly involved the head. One quarter of the patients showed post-traumatic stress disorder.
Discussion: Hand injuries from fireworks often result in permanent physical integrity disorders. Posttraumatic stress disorder is often. The increasing number of cases may be due to structural changes in the rescue service and the level of awareness of a specialized facility, in addition to a fundamental increase in injuries. Most striking was the decline in numbers during the COVID pandemic. The immediate rebound after the end of the restrictions supports the consideration of a permanent ban.
The Relationship Between Leisure Time Physical Activity and Cognitive Function in Older Americans: NHANES 2011-2014
Authors: Yang Juxiang , Wang Yi , Zheng Xi , Wang Hongchu , Song Gang
Published: December 2023

Objective
This study aims to investigate the correlation between leisure-time physical activity (LTPA) and cognitive function in older adults.
Methods
We conducted an analysis of 2,662 participants (aged ≥ 60 years) from the cross-sectional National Health and Nutrition Examination Survey (NHANES) spanning 2011–2014. Physical activity was assessed using self-reported questionnaires, while cognitive function was evaluated through three measurement modalities and self-reported assessments of cognitive difficulties. Multiple logistic regression and multiple linear regression analyses were employed to explore the associations between the duration and frequency of leisure-time physical activity and cognitive function.
Results
Neither the duration nor frequency of leisure-time physical activity (LTPA) showed statistically significant associations with CERAD-WL and CERAD-DR. However, significant correlations were observed between LTPA duration and frequency with AF and DSST scores. Individuals adhering to recommended physical activity guidelines demonstrated higher AF scores [1.38 (0.93 to 1.83)] and DSST scores [3.32 (2.12 to 4.52)] compared to those with no leisure-time physical activity. Participants engaging in physical activity 1–4 times and 5 or more times per week showed increased AF scores [0.89 (0.43 to 1.36)] and [1.40 (0.91 to 1.90)], as well as DSST scores [2.61 (1.36 to 3.86)] and [3.50 (2.17 to 4.83)], respectively, compared to non-active individuals. Engaging in leisure-time physical activity 1–4 times per week was associated with a 33% reduced risk of memory decline compared to non-active individuals (odds ratio [OR] 0.67, 95% confidence interval [CI] 0.48–0.92). An inverted U-shaped relationship was observed between LTPA duration and AF and a U-shaped relationship between LTPA frequency and the risk of memory decline.
Conclusion
Compliance with recommended leisure-time physical activity is associated with better cognitive function in older adults, although greater duration does not necessarily equate to greater benefits. For older adults, the frequency of leisure-time physical activity appears more critical than duration, with the most beneficial cognitive effects observed at 3–4 times per week. Therefore, clinical interventions utilizing physical activity should prioritize considerations of exercise frequency.
KRAS inhibition impacts chromatin organization and transcriptional performance in colorectal cancer cells
Authors: Martins Flávia , Machado Ana Luísa , Ribeiro Andreia , Oliveira Susana Mendonça , Carvalho Joana , Matthiesen Rune , Velho Sérgia
Published: December 2023

Background
Preclinical and clinical data revealed that targeting KRAS mutant tumors is more challenging than expected. While initially sensitive to treatment, cancer cells can rapidly bypass dependence on this oncogene to acquire a drug-tolerant phenotype. Gaining a comprehensive understanding of the mechanisms underlying the transition from a drug-sensitive to a drug-tolerant state is key to obtaining invaluable insights. Such insights will inform the development of therapeutic strategies aimed at disrupting intrinsic or adaptive resistance, ultimately enhancing therapeutic outcomes.
Methods
Building upon this rationale, we established 3D culture models of mutant-KRAS CRC cell lines with distinct KRAS-dependencies to investigate the response to KRAS silencing. siRNA was used to silence KRAS expression. Cells were grown in 3D, characterized, and analyzed using proteomics. Chromatin states were explored via transmission electron microscopy, and transcriptional performance was assessed through longitudinal RNA-Seq.
Results
Our approach revealed a unique response in KRAS-dependent cells characterized by G0/G1 cell cycle arrest and entry into a quiescent-like state. Proteomic analysis revealed nucleosome assembly, regulation of gene expression, mRNA splicing, and mRNA processing as the top biological processes that were upregulated in KRAS-dependent CRC cell lines upon KRAS silencing. Additionally, alterations in histone 3 posttranslational modifications and chromatin compaction were also observed, alongside enhanced transcriptional performance, as revealed by longitudinal RNA-Seq analysis.
Conclusion
Our discoveries substantiate the existence of an epigenetic mechanism responsible for inducing tolerance to KRAS loss. This mechanism involves chromatin reorganization and transcription upregulation, highlighting the remarkable ability of cancer cells to adapt and sustain malignancy without oncogenic KRAS.
Determination of birth prevalence of sickle cell disease using point of care test HemoTypeSC TM at Rundu hospital, Namibia
Authors: Mano Runyararo Mashingaidze , Kuona Patience , Misihairabgwi Jane Masiiwa
Published: December 2023

Background: Sickle cell disease (SCD), a non-communicable disease has its highest burden in Sub Saharan Africa. The majority of children (50-90%), with SCD die before their 5thbirthday with approximately 150,000–300,000 annual SCD child deaths in Africa. In developed countries, newborn screening (NBS) has been shown to improve survival of children with sickle cell disease with under 5 childhood mortality reduced 10 fold due to interventions done before development of complications. Point of care tests have been developed for resource limited settings to expand newborn screening. The aim of the study was to determine the birth prevalence of sickle cell disease using the point of care test HemoTypeSC in Namibia.Methods: A cross sectional descriptive study was carried out at Rundu Intermediate hospital in Kavango East Region. Two hundred and two (202) well newborns within 72 hours of birth were recruited in the study from 22 of February to the 28thof March 2023. Descriptive statistics was used to compute the hemoglobin types of the study participants.Results: The majority of the participants (n=105) (52%) were females and (n= 97) ,(48%) males. The median age of the participants was 23 hours interquartile range (IQR), (11-33 hours) with the age range of 2-98 hours. One hundred and eight three (183) ( 90.6%) had normal haemoglobin HbAA; 19 (9.4%) sickle cell trait (HbAS) and no participant was found to have sickle cell disease (HbSS).Conclusions: The study is the first to carry out birth prevalence for SCD and sickle cell trait as well as the first application of HemotypeSC as screening method in Namibia. There was a high prevalence of sickle cell trait but no SCD. This is a baseline study that can inform policy on the possible adoption of sickle cell disease newborn screening in Namibia.
Carbon balance in the silvopastoral systems of Caldén forest: sources or sinks of greenhouse gases?
Authors: Utello Marco Jesús , Tarico Juan Carlos , Plevich José Omar
Published: December 2023

The objective of the following work was to address, through modeling and field data, a carbon balance as a function of forest cover for a silvopastoral breeding system in native Neltuma caldenia forest. For this, the herbaceous stratum in different forest covers was measured through sampling. Forage production for each tree density was affected by a use factor and was compared with the feed demand of a herd of breeding cows. The load values were affected by the estimated emissions in cattle breeding in the region (1,427 and 2,407 kg eq-CO2 animal− 1 year− 1). The evolution of the parameters of the forest mass was modeled using growth data obtained from 19 dendrometers distributed in 7 permanent plots in different tree densities. The results show that the herbaceous biomass was maximum in the condition of minimum woody cover and that from 8.5 m2 ha− 1 of basal area (BA) the forage yield decreases significantly (P < 0.05). The projected values of the forest flight show that from 2.4 m2 ha− 1 of BA, the eq-CO2 captures in the total tree biomass exceed the emissions of livestock supported by forage availability. If the capture of emissions that are trapped in the stem biomass is considered, the capture exceeds the emissions from 17.5 m2 ha− 1 of BA. It is concluded that managing the Caldén forest with appropriate silvicultural management would allow the production of "carbon neutral meat". The balance did not contemplate the capture of C by the soil.
Interpretable Mortality Prediction Model for ICU Patients with Pneumonia: Using Shapley Additive Explanation Method
Authors: li jiaxi , zhang yu , he shenyang , tang yan
Published: December 2023

Background
Pneumonia, a leading cause of morbidity and mortality worldwide, often necessitates Intensive Care Unit (ICU) admission. Accurate prediction of pneumonia mortality is crucial for tailored prevention and treatment plans. However, existing mortality prediction models face limited adoption in clinical practice due to their lack of interpretability.
Objective
This study aimed to develop an interpretable model for predicting pneumonia mortality in ICUs. Leveraging the Shapley Additive Explanation (SHAP) method, we sought to elucidate the Extreme Gradient Boosting (XGBoost) model and identify prognostic factors for pneumonia.
Methods
Conducted as a retrospective cohort study, we utilized electronic health records from the eICU-CRD (2014–2015) for all adult pneumonia patients. The first 24 hours of each ICU admission records were considered, with 70% of the dataset allocated for model training and 30% for validation. The XGBoost model was employed, and performance was assessed using the area under the receiver operating characteristic curve (AUC). The SHAP method provided insights into the XGBoost model.
Results
Among 10,962 pneumonia patients, in-hospital mortality was 16.33%. The XGBoost model demonstrated superior predictive performance (AUC: 0.732 ± 0.0065) compared to traditional scoring systems and other machine learning method, which achieved an improvement of 8% points. SHAP analysis identified Aspartate Aminotransferase (AST) as the most crucial predictor.
Conclusions
Interpretable predictive models enhance mortality risk assessment for pneumonia patients in the ICU, fostering transparency. AST emerged as the foremost predictor, followed by patient age, albumin, BMI et al. These insights, rooted in strong correlations with mortality, facilitate improved clinical decision-making and resource allocation.
Optimizing DC Microgrid: Fuzzy PI Controller with Metaheuristic Energy Storage Management
Authors: Kavousighahfarokhi Arash , Radzi Mohd Amran Mohd , Noorbakhsh S. Mohammad , Khorshidi Elahe , Dastgerdi Pedram Hematzadeh , Harchegani Amir Torki
Published: December 2023

One of the main issues with power systems that has a direct impact on voltage stability is the balance between power generation and load demand. On the other hand, due to the unpredictable nature of output power generation and the low inertia of these sources in comparison to other conventional sources, raising the penetration ratio of solar and wind power in the Microgrid (MG) may result in a lack of frequency control. The frequency stability performance can also be greatly improved by adjusting the gain of the inertia and drop control loops. However, it seems difficult to modify the aforementioned control coefficients with ordinary PI controllers in order to expect the greatest performance in all circumstances due to variations in wind speed, solar radiation, and load. Therefore, this work, by modelling load fluctuations and generation variations with the cooperation of battery and supercapacitor energy storage in the MG, suggests a control scheme based on a fuzzy gain scheduling PI (FGS-PI) model and improved grey wolf optimization (GWO) algorithm for faster performance and more robustness. Further, the effectiveness of the proposed technique is confirmed by simulation results in MATLAB/Simulink 2021b.
The causal relationship between smoking, alcohol intake, tea intake, coffee intake, and risk of gout: univariate and multivariate Mendelian randomization analysis
Authors: Wang Du , Long Jiaye , Yang Miyang , Pang Yingrong , He Zhiling , Kang Hongyan , Li Zhong
Published: December 2023

Objectives
The precise causal connection between smoking, alcohol consumption, tea consumption, coffee consumption, and gout remains ambiguous. The objective of this article is to investigate the causal connection between smoking, alcohol consumption, tea consumption, coffee consumption, and gout.
Methods
Utilizing univariate and multivariate Mendelian randomization (MR) analyses, the causal relationship between smoking, alcohol consumption, tea consumption, coffee consumption, and gout was investigated. Four supplementary MR techniques were implemented alongside the inverse difference weighted (IVW) method, which served as the primary approach for MR estimation: MR Egger, weighted medium, weighted mode, and simple mode. Furthermore, a multivariate Mendelian randomization analysis was performed to eliminate potential confounding variables that might influence the incidence of gout.
Results
The univariate MR analysis revealed that tea and coffee consumption were associated with a protective causal relationship against gout (OR = 0.13, 95% (confidence interval) CI: 0.03–0.51, P = 0.003; OR = 0.07, 95% CI: 0.01–0.71, P = 0.024). Conversely, smoking and alcohol consumption did not exhibit a causal relationship with gout. A protective causal relationship was observed between tea consumption and gout in a multivariate MR analysis (OR = 0.28, 95% CI: 0.10–0.76, P = 0.012; OR = 0.28, 95% CI: 0.13–0.63, P = 0.002; OR = 0.30, 95% CI: 0.10–0.86, P = 0.025). However, no causal relationship was found between gout and smoking, alcohol consumption, or coffee intake.
Conclusions
Our research findings indicated a potential protective causal relationship between tea consumption and gout.
New pixel-level low-cost Polar Star tracking technique and device for the instantaneous evaluation of atmospheric turbulence (seeing)
Authors: Augusto Pedro , Andrade Ilidio , Lagani Paolo , Conaci Angela
Published: December 2023

Atmospheric turbulence (seeing) transforms a telescope star image into a jumbled mess of light. Seeing has been measured for decades with expensive instrumentation (the cheapest portable versions cost ~10 000€). We recovered the 60-yrs old ‘Walker method’ to expose the Pole Star for five minutes and calculate the seeing using a new technique and device (M.BASE.MATE), the full details of which are given in this paper, including the design, data, and codes. Following the frugal science philosophy, we managed to reduce the cost to ~1000€; we further suggest seeing measurements to be made at sites that we have identified in less developed countries. We tested our method for a full year in Madeira, which is (still) one of the great sites in the world without a professional observatory: sub-arc second seeing three-quarters of the time; average seeing below 0.5 arc seconds (twice better than La Palma in the same period).
Teaser
A new low-cost method for astronomical atmospheric turbulence (seeing) determination is validated at the island of Madeira.
Global and Local Spatial Analysis for the Degradation Rate of Gamma and Neutron Rays in Hiroshima and Nagasaki
Authors: Lotfy Nesma
Published: December 2023

Background
During World War II, Japan experienced significant damage due to the deployment of two atomic bombs in Hiroshima and Nagasaki. However, the degradation rate of the Gamma and Neutron rays, measured using Dosimetry System 1986 (DS86) within around 1.0 km radius from the hypocenter, differ between Hiroshima and Nagasaki. Additionally, the two cities exhibit significant variations in their topography and population density. Therefore, the objective of the present study is to examine the impact of topography and population density on the degradation rate of Gamma.
Methods
Data on topography, population density, and Gamma and Neutron rays in 1945 was acquired from various online resources. A local Wilcoxon test was conducted to examine the differences between Gamma and Neutron degradation rate, as well as differences in Gamma and Neutron degradation rate between Hiroshima and Nagasaki. The Jaccard similarity coefficient was employed to assess the similarity of topography and population density between Hiroshima and Nagasaki. Path analysis, utilizing the GSEM function, was implemented to identify the relationships between topography, population density, and Gamma degradation rate. The study used ArcGIS™ 10.8, R, and STATA 16.0 software.
Results
Observing the degradation rate of Gamma rays emanating from the hypocenter, Hiroshima’s area extends roughly 1.4 km, whereas Nagasaki’s area covers about 1.8 km, with an additional 0.4km region. Concerning the additional area, the Jaccard similarity coefficient between Hiroshima and Nagasaki for topography was calculated to be 0.436, whereas for population density, it measured at 0.685. Regarding path analysis for the additional area, high population density was associated with a better gamma degradation rate (Hiroshima, OR = 0.005; Nagasaki, OR = 0.0014). A high value for topography was associated with a worse gamma degradation rate (OR = 3.52; P = 0.027).
Conclusion
Population density plays an evident role in the Gamma degradation rate. Areas with higher population density exhibit a better degradation rate. On the other hand, regions characterized by challenging topography tend to have lower population density, resulting in a poorer degradation rate, which implies the necessity for additional areas to attain a zero area of rays, consequently giving rise to more health problems.
Unveiling the Impact of 17β-Estradiol on Thymic Epithelial Cell Proliferation: A miRNA Perspective
Authors: Guo Dongguang , Chen Mingyan , He Yaojia , Tian Jinhe , Li Yugu
Published: December 2023

Background Estrogen signaling and microRNA (miRNA) expression play a pivotal role in thymus involution by regulating thymic epithelial cell (TECs) functions. However, the role of Estrogen on miRNA expression in TECs has not been fully elucidated.
Methods Cell proliferation assays, such as the cell-counting kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU) and flow cytometry assays were conducted. Next-generation sequencing (NGS)-based miRNA profiling was performed and validated using Quantitative polymerase chain reaction (qPCR). Additionally, the mechanism of 17β-Estradiol(E2) regulation of miRNA expression in MTEC1 cells was investigated using anti-estrogen ICI 182, 780 and ERα siRNA.
Results A total of 3356 candidate miRNAs across the six miRNA libraries were subjected to analysis, among these, 69 miRNAs displayed notable changes in expression patterns, with 33 miRNAs exhibiting downregulation and 36 miRNAs showing upregulation. Further investigation focused on miR-99a-5p, miR-99b-5p, miR-378a-5p, miR-361-5p, miR-16-5p, and miR-22-3p due to their elevated expression levels. Subsequent examination through Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed a significant association between the dysregulated miRNAs and the functional role of cell proliferation. Furthermore, the regulatory impact of E2 on miRNA expression can be modified by the anti-estrogen ICI 182 780 or inhibited by ERαsiRNA in MTEC1 cells.
Conclusions E2 canalter miRNA expression in TECs, and this miRNA expression may be closely associated with post-transcriptional regulation of cell proliferation in an ERα-dependent manner. Our data indicated the good performance of these miRNAs as potential biomarkers in E2-related thymic involution in TECs.
Optical illusions in different ungulates species
Authors: Berardo Caterina , Holland Ruben , Schaffer Alina , Caicoya Alvaro Lopez , Liebal Katja , Valsecchi Paola , Amici Federica
Published: December 2023

Optical illusions have been used in behavioural studies in recent years to investigate the perceptual mechanisms underlying vision in animals. Although susceptibility to some illusions has been extensively studied in some species, only two studies have yet been carried out in ungulates, suggesting that they may perceive optical illusions in a way similar to humans. Here, we used two food-choice tasks to study susceptibility to the Müller-Lyer and Delboeuf illusions in 17 captive individuals belonging to four ungulate species (Lama guanicoe, Lama glama, Ovis aries, Capra hircus). In control trials, individuals reliably preferred the longer/larger food over the shorter/smaller one. In experimental trials, individuals significantly preferred the food stick between two inward arrowheads over an identical one between two outward arrowheads in the Müller-Lyer task, and they preferred the food on the smaller circle over an identical one on the larger circle in the Delboeuf task, with no significant differences across species. Overall, these findings suggest that, in line with our predictions, ungulates are susceptible to the Müller-Lyer and the Delboeuf illusions in a similar way to humans, and indicate that the perceptual mechanisms underlying size estimation in arctiodactyla might be similar to those of other ungulate and primate species, including humans.
The Conditional Influences of Organizational Climate on the Relationship between the Number and Types of Implementation Strategies and Lupus Decision Aid Acceptability, Appropriateness, and Feasibility
Authors: Hearld Larry , Carroll Nathan , Hall Allyson , Karabukayeva Aizhan , Singh Jasvinder
Published: December 2023

Background: Empirical research is inconsistent regarding the relationship between the number of implementation strategies and the implementation of evidence-based interventions. One potential explanation for inconsistent relationships is an assumption that different types of strategies will have a similar impact on different implementation outcomes. Likewise, relatively little research has considered whether greater (or fewer) numbers of implementation strategies may be more (or less) effective under certain conditions, despite general recognition of the role that implementation strategies can play in overcoming contextual barriers to implementation. The purpose of this paper was to address these gaps by answering three related questions: 1) What is the relationship between the number of implementation strategies and implementation outcomes?; 2) Does the relationship between implementation strategies and implementation outcomes differ for clinic-focused and patient-focused strategies?; and 3) To what extent does the organizational climate strengthen or attenuate the relationship between the number of implementation strategies and implementation outcomes?
Methods: Based on administrative and survey data from 15 U.S. rheumatology clinics that were implementing an evidence-based decision aid for patients with lupus, we used random intercept mixed-effects regression models to examine the association between the total number of implementation strategies (and separately for clinic-focused vs. patient-focused strategies) and clinic staff’ perceptions of decision-aid acceptability, appropriateness, and feasibility. Extensions of the previous models examined whether these relationships were moderated by a clinic’s change readiness and learning climates.
Results: Our analysis suggests that, in aggregate, more strategies do not necessarily result in more positive perceptions of decision-aid acceptability, appropriateness, or feasibility. Additional analyses, however, suggest that the effect of increasing numbers of implementation strategies differ depending on the audience at which the strategy is focused – clinic staff vs. patients. Our moderation analysis also suggests that organizational climate accentuates the relationship between implementation strategies and outcomes in some cases and attenuates the relationship in others.
Conclusions: Collectively, these findings highlight the difficulty of simple, standardized recommendations – e.g., ‘increase the number of implementation strategies’ or ‘clinics should strengthen the readiness or learning climate’. Under some circumstances, increasing the number of implementation strategies may, in fact, have detrimental effects on implementation outcomes.
Trial registration: ClinicalTrials.gov ID: NCT03735238
The Intersection of Parenting and Employment: A Qualitative Exploration of the Experiences of Working Parents
Authors: Adem Bashir Suleiman
Published: December 2023

The primary objective of this research was to delve deeply into the intricate experiences and challenges that arise at the intersection of parenting and employment. It aimed to explore coping mechanisms employed by individuals and investigate the reciprocal impact of employment on parenting. The data collection process involved conducting comprehensive in-depth interviews and structured observations within a working family's household located in the Togdheer region of Somaliland. The study revealed challenges for working parents, such as time constraints, potential child neglect, and a strain on family dynamics due to work commitments. Balancing family life, household responsibilities, and work proved challenging, especially for working mothers. Coping mechanisms included efforts to harmonize work and family duties, seek support, and navigate relationships. The research also explored the reciprocal impact of employment on family dynamics and parenting, revealing both positive and negative effects. Financial stability played a crucial role, and the study highlighted the psychological toll and critical skills needed to juggle diverse responsibilities. Overall, the findings underscore the complex interplay between work, family, and individual well-being. Finally, the research recommended actionable guidance for various stakeholders: Support Systems and Communication: Encouraging working parents to establish dependable family support networks, especially for new working parents. Workplace and Policy Support: Advocating for workplaces to provide comprehensive support for working mothers. Financial Independence and Planning: Promoting the significance of financial independence among working parents, emphasizing premarital discussions to align career and family aspirations, and highlighting the importance of shared financial responsibility within families.
Impact of Mobile Games-Aided Neurorehabilitation: A Systematic Literature Review
Authors:   School of Computer Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia, Sagary Ruvenaa , Malim Nurul Hashimah Ahamed Hassain ,   School of Computer Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia, Abdullah Nasuha Lee ,   School of Computer Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia, Wan Mohamad Wan Nor Azlen ,   Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Hospital Universiti Sains Malaysia, Kelantan, Malaysia, Ahmad Alwani Liyana ,   Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Hospital Universiti Sains Malaysia, Kelantan, Malaysia
Published: December 2023

Neurological rehabilitation is a physician-supervised programme for individuals with nervous system diseases, injuries or disorders. Neurological rehabilitation, also known as neurorehabilitation, is part of the rehabilitation process that improves function, reduces severity and enhances a patient’s well-being. Because neurological injuries occur in the brain, spine and nerves, affecting multiple body parts including organs, blood vessels, muscles and bones, rehabilitation requires a multidisciplinary approach. This study conducted a systematic literature review (SLR) on the use of mobile game in neurorehabilitation. The steps undertaken in the literature review included the collection, identification, categorisation, summarisation and synthesis of relevant studies in the research domain. A total of 50 related articles were reviewed. The study identified that the effects on cognitive skills, handgrip strength, memory, attention, visuospatial abilities, executive function tasks, motor functionality, and improvements in balance, visual perception, and functional mobility are impacts of the use of mobile games in neurological rehabilitation. Furthermore, several research challenges and recommendations for future research were identified.
Driving Global Change One LIP at a Time
Authors: Deegan Frances M. , Callegaro Sara , Davies Joshua H.F.L. , Svensen Henrik H.
Published: December 2023

Earth’s history has been punctuated by extraordinary magmatic events that produced large igneous provinces (LIPs). Many LIPs induced global changes, including millennial-scale warming, terrestrial and oceanic mass extinctions, oceanic anoxic events, and even glaciations. Research over the past 20 years has shown that shallow crustal degassing is an important factor contributing to the environmental impact of LIPs. Contact metamorphism in sedimentary basins can generate huge gas volumes, and operates as a function of magma volume and the architecture of LIP plumbing systems. Numerous open questions remain concerning the role of LIPs in triggering rapid and lasting changes, whose answers require collaboration across geoscientific disciplines. In this issue, we present the status of five key research themes and discuss potential ways forward to better understanding these large-scale phenomena.
Pengaturan Dan Penerapan Surat Izin Membuka Tanah Negara Sebagai Syarat Pendaftaran Hak Atas Tanah di Kota Balikpapan
Authors: Rahmatika Nur Auliya , Qurbani Indah Dwi , Cahyandari Dewi
Published: December 2023

This research departs from the Regional Regulation of Balikpapan City Number 1 of 2014 concerning the Permit to open a State Land while the permit is required as proof of land ownership to register the right to land in Balikpapan city. A stamp statement of the land concerned can be used as proof of land ownership for the registration mentioned above. Based on the above issue, this research aims to investigate the problems regarding (1) the regulation of the provision of the permit used to open a state land as a requirement to register the right to land in Balikpapan city and (2) the implementation of the permit used to open a state land as a requirement to register the right to land in Balikpapan city. This research employed socio-legal and socio-juridical methods and took place in Balikpapan as the first city to put the regulation in place regarding the permit mentioned above as a requirement to register the right to land as governed in a Regional Regulation. His research reveals that the Regional Government of Balikpapan City holds the authority to enforce this regulation according to Law Number 23 of 2014 concerning the Regional Government. The implementation of this permit to open a state land as the proof of land ownership in the registration of the right to land in Balikpapan has not been efficient, while people can still refer to the stamp statement to replace this permit document. Therefore, this research suggests that adjustments regarding the regulation be made to assure legal certainty for the people of Balikpapan.
Perlindungan Hukum Terhadap Konsumen Pre Project Selling Perusahaan Pengembang Properti Yang Dinyatakan Pailit
Authors: Muniefiy Nawal Zidan El , Santoso Budi , Ganindha Ranitya
Published: December 2023

Pre-Project Selling consumers are in the weakest position in bankruptcy, because in addition to being the last creditor, consumers also cannot be said to be the owner if there is no AJB. The Curator's action to put the apartment building into bankruptcy is in accordance with the provisions of the law. Legal protection involves both preventing and repressive protections. In terms of preventive action, the sale and purchase agreement (PPJB) legally made according to Article 1338 of Civil Law serves as the law governing all parties in the contract. The PPJB which is binding to both consumers and business people sets forth rights and obligations that both have to understand. The rights of the consumers involve receiving the house as the object within the time as agreed upon. Moreover, the law requires the business people to run the business in good faith. The parties responsible to provide goods and/or services according to the orders made must not break the terms set out in a contract and must provide redress. This redress consists of that given through commercial court, consumer redress according to the position as concurrent creditors, or redress of the company through civil lawsuits. Law concerning bankruptcy and Consumer Protection Law have different solutions, but these two laws affect each other and are connected when a property company is declared bankrupt.
Élise Hugueny-Léger, Projections de soi. Identités et images en mouvement dans l'autofiction
Authors: Koffeman Maaike
Published: December 2023

Playing on the double meaning of the word projection, this book explores the multiple relationships between the French literary genre of autofiction and the moving image. Élise Hugueny-Léger, a researcher of contemporary French literature and a specialist of the work of Annie Ernaux, departs from the idea that autofictional writing is a form of psychological projection, wherein a self-image is being cast onto the page. In a more literal sense, the word projection refers to the cinematic technique of showing moving images on a screen. Several francophone authors known for their autofiction have also been involved in audiovisual productions, but earlier criticism has largely limited itself to studying their literary output. By addressing this rich and complex subject matter, Hugueny-Léger makes a valuable and original contribution to the field of francophone life-writing studies.
General Introduction
Authors: Lenz Martin
Published: December 2023

Abstract: This is the introduction to the Special Issue Intersubjective Readings of Spinoza. Critical Comments on Martin Lenz’ Socializing Minds: Intersubjectivity in Early Modern Philosophy, New York: Oxford University Press 2022. It provides an overview of the topic that the papers in this issue are centered around as well as an outline of main theses of the pertinent book and acknowledgments for the related workshop.
Agreement or Contrariety? A Dialogue
Authors: Bella Daniel
Published: December 2023

In one of his blog posts, Martin Lenz refers to Wittgenstein’s Rabbit-duck; a picture puzzle that can interpretated as depicting a rabbit or a duck. The point of this analogy is that what we are perceiving corresponds to our personal experiences which can be shaped in discussions with others even though we remain incapable to grasp both pictures at once. The starting point of the following dialogue is exactly such a Rabbit-duck-illusion. Reading Lenz’ chapter on Spinoza again and again, I remained unsure whether contrariety or agreement is the fundamental relation which warrants his claim that minds are intrinsically social. The aim of this text is to enter into dialogue on this subject and examine the problems and advantages of both readings. Must it necessarily be the case that contrariety and agreement are mutually exclusive like the two parts of the Rabbit-duck?
Reply to Nadler: Spinoza’s Free Person and Wise Person Reconsidered
Authors: Soyarslan Sanem
Published: December 2023

This article addresses Steven Nadler’s response to my objections to his reading of Spinoza’s free person (homo liber). Nadler argues that there are no clear and significant differences between the free person and the wise person (vir sapiens) in their character or in the role they play in Spinoza’s moral philosophy; in fact, they are one and the same. I begin by critically examining three inferences which Nadler’s reading in part relies on. I then address the differences between the contexts in which Spinoza explicitly invokes the free person and the wise person. I argue that even though there may not be significant differences between the free person and the wise person in terms of their character and comportment, there is still reason to think that the free person plays a particular role in Spinoza’s moral philosophy—one which does not hinge on the attainment of the cognitive and affective excellence represented by the wise person at the end of the Ethics.
Elaboración y caracterización de pisos de ingeniería elaborados con maderas de diferentes densidades
Authors: Barrera Cruz Omar Isaí , Rodríguez Anda Raúl , Silva Guzmán José Antonio , Fuentes Talavera Francisco Javier
Published: December 2023

Una opción para incrementar el valor de las maderas de baja densidad puede ser el combinarlas con especies de densidades más altas. A los productos que combinan madera de diferentes propiedades se les conoce como productos de ingeniería. El presente trabajo tuvo como objetivo diseñar, producir y evaluar, a través de sus propiedades físicomecánicas, un piso de ingeniería de 16 mm de espesor. Este producto se conformó de tres capas, utilizando palma de coco (Cocos nucifera) o melina (Gmelina arborea) como sustrato y encino rojo (Quercus castanea) como refuerzo. Se ensayaron tres tipos de adhesivos: urea formaldehido, henkel loctite y soya furfural. Con los dos sustratos utilizados, se obtuvo una densidad normal promedio de 0.53 g cm-3 a un contenido de humedad promedio de 9%. La resistencia a la flexión fluctuó entre 12 MPa y 62 MPa y el módulo de elasticidad entre 1346 MPa y 10 660 MPa. La combinación de encino-melina-encino con urea formaldehido fue la que presentó los mejores resultados. La dureza Brinell exhibió valores de 30 N mm-2 a 48 N mm-2 y la combinación encino-palma-encino con loctite fue la que arrojó el mayor valor. La resistencia al cortante de la línea de encolado fue de 0.11 MPa a 3.46 MPa. Las combinaciones encino-palma-encino soya furfural, encino-palma-encino urea formaldehido, así como encino-melina-encino urea formaldehido no presentaron diferencias estadísticas significativas en la resistencia de la línea adhesiva. Los pisos con urea formaldehido y con soya furfural fueron susceptibles a la delaminación al contacto directo con el agua y ante cambios de humedad relativa en el ambiente de 35% y 55%.
Bricolaje institucional: un enfoque para analizar los resultados del pago por servicios ambientales en Chiapas, México
Authors: Caballero Salinas Juan Carlos , Vargas Vencis Perla , Perevochtchikova María
Published: December 2023

Los pagos por servicios ambientales (PSA) fueron diseñados como instrumentos de mercado que proporcionan un incentivo económico a propietarios de terrenos forestales para asegurar condicionalmente la provisión de servicios ecosistémicos. Diversas investigaciones han demostrado que no existe un consenso sobre sus efectos socioambientales. Además, poco se sabe acerca de los factores que influyen en la magnitud y la direccionalidad (positivo/negativo) de sus resultados. El bricolaje institucional es un enfoque que ayuda a comprender los resultados de políticas públicas ambientales, incluyendo el PSA. El bricolaje ocurre cuando los actores involucrados mezclan regulaciones propias, tradiciones, normas y relaciones de poder que dan origen a nuevos diseños institucionales. A través de técnicas etnográficas se retoma el concepto de bricolaje institucional para analizar el desempeño del programa federal de PSA en el ejido Tierra y Libertad, Jiquipilas, en el estado de Chiapas. La investigación de campo reveló que las regulaciones del PSA fueron moldeadas a escala local por los bricoleurs (actores locales) que hicieron uso de sus atributos, agencia y relaciones de poder para adaptar, reinterpretar o rechazar las regulaciones del programa; este cambio institucional condujo a resultados socioambientales no previstos. Por lo tanto, se sugiere considerar las realidades locales de territorios donde se introducen los esquemas de PSA, debido a que en algunos contextos socioecológicos las regulaciones carecen de integración y aceptación en las normas y prácticas productivas.
Diversity and enzymatic activity of some fungi isolated from agricultural soil
Authors: Muhsen Nemat A. , Al-Dossary Mustafa A.
Published: December 2023

Fungi are one of the most important groups of microorganisms in the environment, and due to their ability to produce several types of enzymes, they play an essential role in the environment. During this study, fourteen species of fungi were isolated from fifteen soil samples collected from several agricultural areas in Basrah Governorate, southern Iraq, and their enzymatic activity was tested for four extracellular enzymes (cellulase C, laccase La, lipase Lp, and manganese peroxidase Mp) on specific solid media. The isolated fungi showed good enzymatic activity, in which 12 fungal species can secret manganese peroxidase, 11 can secret cellulase, 9 can secret lipase, and five can secret laccase enzyme. Aspergillus candidus and A. versicolor showed a positive detection for all enzymes, Cladosporium showed positive detection for C, Lp, and Mp, while Mucor sp. showed negative detection for all enzymes.
Keywords: Enzymatic activity, Fungal diversity, soil.
The Evolution of Artificial Intelligence in Biomedicine: Bibliometric Analysis
Authors: Gu Jiasheng , Gao Chongyang , Wang Lili
Published: December 2023

Background

The utilization of artificial intelligence (AI) technologies in the biomedical field has attracted increasing attention in recent decades. Studying how past AI technologies have found their way into medicine over time can help to predict which current (and future) AI technologies have the potential to be utilized in medicine in the coming years, thereby providing a helpful reference for future research directions.

Objective

The aim of this study was to predict the future trend of AI technologies used in different biomedical domains based on past trends of related technologies and biomedical domains.

Methods

We collected a large corpus of articles from the PubMed database pertaining to the intersection of AI and biomedicine. Initially, we attempted to use regression on the extracted keywords alone; however, we found that this approach did not provide sufficient information. Therefore, we propose a method called “background-enhanced prediction” to expand the knowledge utilized by the regression algorithm by incorporating both the keywords and their surrounding context. This method of data construction resulted in improved performance across the six regression models evaluated. Our findings were confirmed through experiments on recurrent prediction and forecasting.

Results

In our analysis using background information for prediction, we found that a window size of 3 yielded the best results, outperforming the use of keywords alone. Furthermore, utilizing data only prior to 2017, our regression projections for the period of 2017-2021 exhibited a high coefficient of determination (R2), which reached up to 0.78, demonstrating the effectiveness of our method in predicting long-term trends. Based on the prediction, studies related to proteins and tumors will be pushed out of the top 20 and become replaced by early diagnostics, tomography, and other detection technologies. These are certain areas that are well-suited to incorporate AI technology. Deep learning, machine learning, and neural networks continue to be the dominant AI technologies in biomedical applications. Generative adversarial networks represent an emerging technology with a strong growth trend.

Conclusions

In this study, we explored AI trends in the biomedical field and developed a predictive model to forecast future trends. Our findings were confirmed through experiments on current trends.