bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal assessment of chemotherapy-induced brain connectivity changes in cerebral white matter and its correlation with cognitive functioning using the GQI
Authors: Chen Vincent Chin-Hung , Chuang Wei , Tsai Yuan-Hsiung , McIntyre Roger S. , Weng Jun-Cheng
Published: February 2024

Objective

Breast cancer was the most prevalent type of cancer and had the highest incidence rate among women worldwide. The wide use of adjuvant chemotherapy might have a detrimental effect on the human brain and result in chemotherapy-related cognitive impairment (CICI) among breast cancer patients. Furthermore, prior to chemotherapy, patients reported cancer-related cognitive impairment (CRCI), which might be due to physiological factors or mood symptoms. The present longitudinal study aimed to investigate microstructural and macroscale white matter alterations by generalized q-sampling imaging (GQI).

Methods

The participants were categorized into a pre-chemotherapy group (BB) if they were diagnosed with primary breast cancer and an age-matched noncancer control group (HC). Some participants returned for follow-up assessment. In the present follow up study, 28 matched pairs of BB/BBF (follow up after chemotherapy) individuals and 28 matched pairs of HC/HCF (follow up) individuals were included. We then used GQI and graph theoretical analysis (GTA) to detect microstructural alterations in the whole brain. In addition, we evaluated the relationship between longitudinal changes in GQI indices and neuropsychological tests as well as psychiatric comorbidity.

Findings

The results showed that disruption of white matter integrity occurred in the default mode network (DMN) of patients after chemotherapy, such as in the corpus callosum (CC) and middle frontal gyrus (MFG). Furthermore, weaker connections between brain regions and lower segregation ability were observed in the post-chemotherapy group. Significant correlations were observed between neuropsychological tests and white matter tracts of the CC, MFG, posterior limb of the internal capsule (PLIC) and superior longitudinal fasciculus (SLF).

Conclusion

The results provided evidence of white matter alterations in breast cancer patients, and they may serve as potential imaging markers of cognitive changes. In the future, the study may be beneficial to create and evaluate strategies designed to maintain or improve cognitive function in breast cancer patients undergoing chemotherapy.
Outpatient care for facial palsy—a survey on patient satisfaction in uni- and interdisciplinary approaches
Authors: Machetanz Kathrin , Oberle Linda , Wang Sophie S. , Weinbrenner Eliane , Gorbachuk Mykola , Lauer Henrik , Daigeler Adrien , Tatagiba Marcos , Naros Georgios , Schäfer Ruth C.
Published: February 2024

Objective

The various causes of facial palsy, diagnostic methods and treatment approaches frequently involve different medical specialities. Nevertheless, there exist only few specialized consultation and therapy services for patients with facial palsy (FP) in Germany. The aim of the present study was to evaluate factors affecting quality of life (QoL) and treatment satisfaction of patients presenting to an interdisciplinary facial nerve outpatient clinic.

Methods

The study analyzed patients presenting to the interdisciplinary facial palsy outpatient clinic in Tuebingen between February 2019 and December 2022. General satisfaction and QoL was estimated by numerous self-rating questionnaires: ZUF-8, SF-36, FDI, FaCE, PHQ-9. An ANOVA was performed to analyze determinants affecting the ZUF-8. Correlation analyses between cause and regeneration of FP as well as questionnaire scores were performed. Results were compared with a group of patients who were managed in an unidisciplinary setting.

Results

In total, 66 patients with FP were enrolled. FP patients showed increased levels of depression (PHQ-9: 14.52 ± 3.8) correlating with recovery of the palsy (p = 0.008), FaCE (p < 0.001) and FDI ratings (p < 0.001). There was a high level of satisfaction with the services provided during the uni-and interdisciplinary consultation (ZUF-8: 24.59 ± 6.2), especially among the 12/66 patients who received reconstructive, surgical treatment. However, some patients requested more psychological and ophthalmological support.

Conclusion

High levels of treatment satisfaction can be achieved in both an uni-and interdisciplinary setting. However, multimodal therapy approaches should be applied, considering physical and psychological aspects. In the absence of recovery, surgical interventions must be considered as treatment options. Further studies should continue to investigate potential differences between uni-and interdisciplinary treatment.
Systematic review and meta-analysis of the diagnostic value of optokinetic after-nystagmus in vestibular disorders
Authors: Reynders Marie , Van der Sypt Lynn , Bos Jelte , Cools Wilfried , Topsakal Vedat
Published: February 2024

Introduction

To date, no systematic review or meta-analysis has critically evaluated the relevance of using optokinetic after-nystagmus (OKAN) in diagnosis of vestibular disorders. To assess the role of OKAN in diagnosis of vestibular disorders, the OKAN time constant (TC) between patients with vestibular disorders and healthy participants will be compared.

Methods

Automated search strategies were carried out in the Embase, Medline PubMed, Web of Science, and Scopus databases from inception to December 2023. The following inclusion criteria were applied: (1) evaluation of OKAN in individuals with vestibular disorders, (2) clinical trials, and (3) inclusion of healthy individuals as the control group. Exclusion criteria were: (1) animal studies, (2) non-clinical trial study designs, (3) assessment of non-vestibular disorders, (4) no examination of OKAN TC, (5) only examination of healthy participants, (6) studies published in a language other than English, (7) no healthy participants as control group, (8) case reports, and (9) only abstract available. The random-effects model was used to pool the data. The Joanna Briggs Institute (JBI) Critical Appraisal Tools was used to assess the risk of bias. The quality assessment was performed with the aid of the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, provided by NHLBI. The PRISMA guidelines were used as reporting guidelines. The main outcome of this study was the between-group mean difference (MDbetween) in OKAN TC and its 95% confidence interval between patients with vestibular disorders and healthy participants.

Results

Seven out of 244 screened articles were included that studied 289 participants. The overall mean difference (MD = −7.08) with a 95% CI of [−10.18; −3.97] was significant (p = 0.014). The heterogeneity was significant (p = 0.02). Quality assessment was generally good (76%). The risk of bias was low in five studies and moderate in two studies.

Conclusion

The results demonstrate that OKAN TC is significantly shorter in patients with vestibular disorders compared to healthy controls. This finding is important for future research, particularly with the emergence of novel clinical tools and diagnostic syndromes.

Systematic Review

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=442695.
Tractography-based DBS lead repositioning improves outcome in refractory OCD and depression
Authors: Basich-Pease Genevieve , Slepneva Natalya , Frank Adam C. , Norbu Tenzin , Morrison Melanie A. , Sugrue Leo P. , Larson Paul S. , Starr Philip A. , Lee A. Moses
Published: February 2024

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) has been used to treat refractory obsessive-compulsive disorder (OCD) and depression, but outcomes are variable, with some patients not responding to this form of invasive neuromodulation. A lack of benefit in some patients may be due to suboptimal positioning of DBS leads. Recently, studies have suggested that specific white matter tracts within the ALIC are associated with improved outcomes. Here, we present the case of a patient who initially had a modest improvement in OCD and depressive symptoms after receiving DBS within the ALIC. Subsequently, he underwent unilateral DBS lead repositioning informed by tractography targeting the ventrolateral and medial prefrontal cortex’s connection with the mediodorsal thalamus. In this patient, we also conducted post-implant and post-repositioning diffusion imaging and found that we could successfully perform tractography even with DBS leads in place. Following lead repositioning into tracts predictive of benefit, the patient reached responder criteria for his OCD, and his depression was remitted. This case illustrates that tractography can potentially be used in the evaluation and planning of lead repositioning to achieve therapeutic outcomes.
A unified model for cross-modal plasticity and skill acquisition
Authors: Park Woon Ju , Fine Ione
Published: February 2024

Historically, cross-modal plasticity following early blindness has been largely studied in the context of visual deprivation. However, more recently, there has been a shift in focus towards understanding cross-modal plasticity from the perspective of skill acquisition: the striking plasticity observed in early blind individuals reflects the extraordinary perceptual and cognitive challenges they solve. Here, inspired by two seminal papers on skill learning (the “cortical recycling” theory) and cross-modal plasticity (the “metamodal” hypothesis) respectively, we present a unified hypothesis of cortical specialization that describes how shared functional, algorithmic, and structural constraints might mediate both types of plasticity.
Autosomal recessive cerebellar ataxias: a diagnostic classification approach according to ocular features
Authors: Lopergolo Diego , Rosini Francesca , Pretegiani Elena , Bargagli Alessia , Serchi Valeria , Rufa Alessandra
Published: February 2024

Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of neurodegenerative disorders affecting primarily the cerebellum and/or its afferent tracts, often accompanied by damage of other neurological or extra-neurological systems. Due to the overlap of clinical presentation among ARCAs and the variety of hereditary, acquired, and reversible etiologies that can determine cerebellar dysfunction, the differential diagnosis is challenging, but also urgent considering the ongoing development of promising target therapies. The examination of afferent and efferent visual system may provide neurophysiological and structural information related to cerebellar dysfunction and neurodegeneration thus allowing a possible diagnostic classification approach according to ocular features. While optic coherence tomography (OCT) is applied for the parametrization of the optic nerve and macular area, the eye movements analysis relies on a wide range of eye-tracker devices and the application of machine-learning techniques. We discuss the results of clinical and eye-tracking oculomotor examination, the OCT findings and some advancing of computer science in ARCAs thus providing evidence sustaining the identification of robust eye parameters as possible markers of ARCAs.
Restoring GABAB receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior
Authors: Hleihil Mohammad , Benke Dietmar
Published: February 2024

Repeated exposure to psychostimulants such as methamphetamine (METH) induces neuronal adaptations in the mesocorticolimbic dopamine system, including the ventral tegmental area (VTA). These changes lead to persistently enhanced neuronal activity causing increased dopamine release and addictive phenotypes. A factor contributing to increased dopaminergic activity in this system appears to be reduced GABAB receptor-mediated neuronal inhibition in the VTA. Dephosphorylation of serine 783 (Ser783) of the GABAB2 subunit by protein phosphatase 2A (PP2A) appears to trigger the downregulation GABAB receptors in psychostimulant-addicted rodents. Therefore, preventing the interaction of GABAB receptors with PP2A using an interfering peptide is a promising strategy to restore GABAB receptor-mediated neuronal inhibition. We have previously developed an interfering peptide (PP2A-Pep) that inhibits the GABAB receptors/PP2A interaction and thereby restores receptor expression under pathological conditions. Here, we tested the hypothesis that restoration of GABAB receptor expression in the VTA of METH addicted mice reduce addictive phenotypes. We found that the expression of GABAB receptors was significantly reduced in the VTA and nucleus accumbens but not in the hippocampus and somatosensory cortex of METH-addicted mice. Infusion of PP2A-Pep into the VTA of METH-addicted mice restored GABAB receptor expression in the VTA and inhibited METH-induced locomotor sensitization as assessed in the open field test. Moreover, administration of PP2A-Pep into the VTA also reduced drug seeking behavior in the conditioned place preference test. These observations underscore the importance of VTA GABAB receptors in controlling addictive phenotypes. Furthermore, this study illustrates the value of interfering peptides targeting diseases-related protein-protein interactions as an alternative approach for a potential development of selective therapeutic interventions.
Clinical outcomes of atezolizumab versus standard-of-care docetaxel with and without ramucirumab in patients with advanced non-small-cell lung cancer who received prior immunotherapy
Authors: Li Shenduo , Manochakian Rami , Chen Ruqin , Patel Jaydeepbhai , Inampudi Jyothik Varun , Hiren Koshiya R. , Zhao Yujie , Lou Yanyan
Published: February 2024

Background

Atezolizumab is superior to docetaxel for patients with advanced non-small-cell lung cancer (NSCLC) who are pretreated with platinum-based chemotherapy based on the POPLAR and OAK trials. However, patients who received prior immunotherapy were excluded from these trials. The standard of care second-line therapy for these patients remains to be docetaxel with or without ramucirumab. The efficacy and safety of atezolizumab as a subsequent therapy in immunotherapy-pretreated patients are unknown.

Methods

We conducted a retrospective study of all patients with locally advanced or metastatic NSCLC who were pretreated with immunotherapy at Mayo Clinic Jacksonville and Rochester from 2016 to 2022. Patients who received subsequent therapy of atezolizumab alone (Atezo), docetaxel (Doce), or docetaxel + ramucirumab (Doce+Ram) were included.

Results

In this cohort of 165 patients, 12.7% (n=21), 49.1% (n=81), and 38.2% (n=63) patients received subsequent Atezo, Doce, and Doce+Ram, respectively. 1-year landmark progression-free survival (PFS) were 23.8%, 6.2%, and 3.2% (p=0.006), and 2-year landmark PFS were 14.3%, 0%, and 0% (p<0.0001), in the Atezo, Doce, and Doce+Ram groups, respectively. About 20% patients with positive PD-L1 had durable response to atezolizumab. The Atezo group showed significantly greater overall survival (OS) improvement over Doce group (median OS 17.7 vs. 7.7 months, HR 0.47, 95% CI 0.29 – 0.76, p=0.008), and over Doce+Ram group (median OS 17.7 vs. 8.9 months, HR 0.55, 95% CI 0.32 – 0.95, p=0.047). 4 of 21 (19%) patients in the Atezo group developed immune-related adverse events (irAE).

Conclusion

We observed statistically significant and clinically meaningful overall survival benefits of atezolizumab monotherapy compared with docetaxel +/- ramucirumab in patients with advanced NSCLC who were pretreated with immunotherapy. The survival benefit seems to be mainly from PD-L1 positive patients. Subsequent immunotherapy with Atezolizumab did not increase irAE rate.
Risk of potential hepatotoxicity from pirfenidone or nintedanib in patients with idiopathic pulmonary fibrosis: results of a retrospective analysis of a large insurance database in Taiwan
Authors: Liao Kuang-Ming , Chen Chung-Yu
Published: February 2024

Background: A growing population of individuals diagnosed with idiopathic pulmonary fibrosis (IPF) are receiving treatment with nintedanib and pirfenidone. The aim of our study was to assess the incidence of drug-induced liver injury (DILI) associated with the use of pirfenidone and nintedanib in patients with IPF in Taiwan.

Methods: We collected a cohort of adult patients diagnosed with IPF between 2017 and 2020. The research outcomes involved assessing the incidence of DILI in patients treated with nintedanib or pirfenidone. Poisson regression analysis was employed to estimate incidence rates, with and without adjustments for covariates, to calculate and present both unadjusted and adjusted incidence rate ratios (IRRs).

Results: The risk of DILI was greater in patients who received nintedanib than in those who received pirfenidone during the 1-year follow-up. Patients treated with nintedanib exhibited a heightened risk of DILI based on inpatient diagnoses using specific codes after adjusting for variables such as gender, age group, comorbidities and concomitant medications, with an adjusted incidence rate ratio (aIRR) of 3.62 (95% confidence interval (CI) 1.11–11.78). Similarly, the risk of DILI was elevated in patients treated with nintedanib according to a per-protocol Poisson regression analysis of outcomes identified from inpatient diagnoses using specific codes. This was observed after adjusting for variables including gender, age group, comorbidities, and concomitant medications, with an aIRR of 3.60 (95% CI 1.11–11.72).

Conclusion: Data from postmarketing surveillance in Taiwan indicate that patients who received nintedanib have a greater risk of DILI than do those who received pirfenidone.
Widening the frontiers of elastography in biomechanics: simultaneous muscle elasticity measurements at high-sample rate with surface wave elastography
Authors: Grinspan Gustavo A. , Oliveira Liliam Fernandes De , Brandao Maria Clara , Benech Nicolás
Published: February 2024

Introduction: In recent years, elastography has become a widely accepted methodology to assess the longitudinal shear elastic modulus of skeletal muscle. Ultrasound shear wave elastography is the gold standard used for such a purpose. However, its low sample rate (1–2 Hz) and the impossibility of being used in several muscles simultaneously limit potential biomechanical applications. In this work, we overcome such limitations by using a surface wave elastography method (NU-SWE).

Methods: The NU-SWE comprises a wearable device suitable for measuring several muscles simultaneously. Elasticity can be measured at high-frequency rates (∼15 Hz), by propagating several pulse trains of low-frequency (∼100 Hz) superficial waves separated by a short time interval. These pulses propagate along the medium surface and are recorded by a linear array of vibration sensors placed on the skin of each measured muscle. In this context, this work carried out a proof of concept, showing how NU-SWE enables performing experimental protocols previously impracticable with ultrasound elastography. Thus, we measured the longitudinal shear elasticity of the biceps brachii and brachioradialis muscles simultaneously at 15 Hz during isometric elbow flexions exerted at different torque development rates. Furthermore, for comparison, we measured the electromyographic activity of both muscles.

Results: Our results show that the maximum elasticity reached by the brachioradialis increases with contraction rate, while the biceps brachii behaves inversely.

Discussion: This study provides new insights concerning muscle synergism, evidenced by changes in muscle elasticity during torque production. More generally, it shows that NU-SWE could help widen elastography-driven research in biomechanics.
Oligo-barcode illuminates holocentric karyotype evolution in Rhynchospora (Cyperaceae)
Authors: Mata-Sucre Yennifer , Parteka Letícia Maria , Ritz Christiane M. , Gatica-Arias Andrés , Félix Leonardo P. , Thomas William Wayt , Souza Gustavo , Vanzela André L. L. , Pedrosa-Harand Andrea , Marques André
Published: February 2024

Holocentric karyotypes are assumed to rapidly evolve through chromosome fusions and fissions due to the diffuse nature of their centromeres. Here, we took advantage of the recent availability of a chromosome-scale reference genome for Rhynchospora breviuscula, a model species of this holocentric genus, and developed the first set of oligo-based barcode probes for a holocentric plant. These probes were applied to 13 additional species of the genus, aiming to investigate the evolutionary dynamics driving the karyotype evolution in Rhynchospora. The two sets of probes were composed of 27,392 (green) and 23,968 (magenta) oligonucleotides (45-nt long), and generated 15 distinct FISH signals as a unique barcode pattern for the identification of all five chromosome pairs of the R. breviuscula karyotype. Oligo-FISH comparative analyzes revealed different types of rearrangements, such as fusions, fissions, putative inversions and translocations, as well as genomic duplications among the analyzed species. Two rounds of whole genome duplication (WGD) were demonstrated in R. pubera, but both analyzed accessions differed in the complex chain of events that gave rise to its large, structurally diploidized karyotypes with 2n = 10 or 12. Considering the phylogenetic relationships and divergence time of the species, the specificity and synteny of the probes were maintained up to species with a divergence time of ~25 My. However, karyotype divergence in more distant species hindered chromosome mapping and the inference of specific events. This barcoding system is a powerful tool to study chromosomal variations and genomic evolution in holocentric chromosomes of Rhynchospora species.
Socio-economic impact of the COVID-19 pandemic on Overseas Filipino Workers and their left-behind families: a scoping review
Authors: Gomez-Magdaraog Kristel May , Burton-Jeangros Claudine , Jackson Yves
Published: February 2024

Overseas Filipino Workers (OFWs) are consideredbagong bayani, or modern-day heroes, as their remittances have a positive long-term impact on the Philippines economy. The Philippines ranked 10thworldwide in terms of net emigration from 2010 to 2020. The deployment of OFWs declined during the pandemic, and this was estimated to have adverse effects on remittances. As a migrant-sending country, the Philippine government had to deal with the mass of unemployed OFWs stranded in their host countries and organize large-scale repatriation of OFWs. This scoping review aims to assess the existing literature, identify research gaps, and propose future research directions concerning the socio-economic impact of the COVID-19 pandemic on OFWs and their left-behind families. The results indicate that the impact of the pandemic on OFWs was not uniform. It is evident that OFWs in precarious situations beforehand have become even more vulnerable. The loss of their source of income in the host country and the restrictions on international mobility during the pandemic had significant detrimental effects on their wellbeing and their families left behind, regardless of their income level or type of job. Upon returning to their home country, they often experienced anxiety, depression, discrimination, and difficulty in finding a job. Overall, this scoping review highlights the urgent need for greater recognition and protection of OFWs in times of crisis. It is crucial to address the systemic issues that contribute to their vulnerability and to ensure that they receive adequate support and protection in host countries and the Philippines.
Stressors and coping strategies among secondary school male students in Abha City, Saudi Arabia
Authors: Alsaleem Safar Abadi , Al-qahtani Abdulaziz Hassan , Al-qahtani Essa Hasan , AlKhaldi Yahia Mater
Published: February 2024

Background

Stress is a biological process in which exposure to stressors is associated with bad health effects, decreased ability of disease management, and a higher likelihood for disease-related complications and comorbidities. Stress has been considered the main factor in the etiology of many diseases such as diabetes mellitus, cardiac diseases, and body aches for centuries. Students meet many stressful situations such as the need for success, academic demands, homesickness, and lack of social support. Coping with stress can be a leading cause in preventing psychological distress and a serious illness.

Methods

A correlational cross-sectional approach was applied to the current research. The research targeted all secondary school male students in Abha city. A multistage cluster sample was applied by selecting schools and students from the Directorate of Education in Abha. Self-administered questionnaire sheets were distributed to students in their classes. The questionnaire covered students’ sociodemographic data such as age, grades, parents’ education and work, living conditions, and comorbidities. Stressors to which the students were exposed were also enumerated with the degree of stress for each. Stress was assessed using the Holmes–Rahe Stress Inventory for youth. Coping skills were measured using the abbreviated version of the COPE Inventory.

Results

The study included 324 students whose ages ranged from 15 to 20 years old with a mean age of 17 ± 0.9 years old. Approximately 33% of the students were in first grade; 44.4% of the students had no or minimal level of stress while major stress was recorded among 26.5% of the students. In total, 77.8% of the students had moderate coping and none had high coping ability.

Conclusion

The study revealed that more than half of the students had significant levels of stress and one out of each four had major stress. The most common stressors were due to the school environment and future planning. Young age, low socioeconomic status, parents’ separation, and having chronic health problems were the most important determinants of stress among the students.
Sustained training with novel distractors attenuates the behavioral interference of emotional pictures but does not affect the electrocortical markers of emotional processing
Authors: Ferrari Vera , Canturi Francesca , De Cesarei Andrea , Codispoti Maurizio
Published: February 2024

Introduction

Research has recently shown that behavioral interference prompted by emotional distractors is subject to habituation when the same exemplars are repeated, but promptly recovers in response to novel stimuli. The present study investigated whether prolonged experience with distractors that were all novel was effective in shaping the attentional filter, favoring stable and generalizable inhibition effects.

Methods

To test this, the impact of emotional distractors was measured before and after a sustained training phase with only novel distractor pictures, and that for a group of participants depicted only a variety of neutral contents, whereas a different group was exposed only to emotional contents.

Results

Results showed that emotional interference on reaction times was attenuated after the training phase (compared to the pre-test), but emotional distractors continued to interfere more than neutral ones in the post-test. The two groups did not differ in terms of training effect, suggesting that the distractor suppression mechanism developed during training was not sensitive to the affective category of natural scenes with which one had had experience. The affective modulation of neither the LPP or Alpha-ERD showed any effect of training.

Discussion

Altogether, these findings suggest that sustained experience with novel distractors may attenuate attention allocation toward task irrelevant emotional stimuli, but the evaluative processes and the engagement of motivational systems are always needed to support the monitoring of the environment for significant cues.
Examining evidence for a relationship between human-animal interactions and common mental disorders during the COVID-19 pandemic: a systematic literature review
Authors: Barr H. K. , Guggenbickler A. M. , Hoch J. S. , Dewa C. S.
Published: February 2024

Introduction

COVID-19 lockdowns, shelter in place, closures of transportation and mental health services, and dearth of mental health providers created new barriers to obtaining support for mental health needs at a time of increased rates of anxiety and depression. During the pandemic, a record number of households owned and adopted pets, opening a potential avenue to investigate the relationship between pets and mental health. This systematic literature review examined the question: What is the evidence for a relationship between human-animal interaction and/or animal ownership and common mental disorders among adults who interacted with pets compared to adults who did not during the COVID-19 pandemic?

Methods

To address this question, four databases were searched: Medline, PsycINFO, Web of Science, and SCOPUS for peer-reviewed literature published between 2020 and July 2023. Of the 1,746 articles identified by the searches, 21 studies were included in this review.

Results

Results suggest that there exists a relationship between animal ownership and strong pet attachment and pet interaction, though the directionality of the relationship was not investigated by the included studies. There was an association between having a stronger relationship with a pet and lower feelings of depression and other mental health symptoms. There was also evidence of an association between anxiety and higher levels of animal attachment.

Conclusion

Understanding the association between human-animal interaction and common mental disorders may be helpful to clinicians assessing the mental health of clients. Clinicians may glean additional insight about stressors, risk factors, social supports, and lifestyle of clients based on the client's status as a pet owner. Future research could further explore the direction of the causal relationship of human-animal interaction and/or animal ownership on common mental disorders; this could further inform how the HAI relationship can be used to support clients with mental health struggles.
The Menstrual Cycle: A Superpower
Authors: Murata Elle M. , Jacobs Emily G.
Published: February 2024

The menstrual cycle is more than just a period—it is a series of events that lasts the whole month. Across the menstrual cycle, sex hormones coordinate changes throughout the body, preparing it for a potential pregnancy. Like body temperature or pulse rate, the menstrual cycle is one measurement of the body’s basic functioning. When the cycle is not functioning as it should be, that might signal that something is wrong. There are several common disorders that cause irregular menstrual cycles. Although they are common, scientists, and doctors still do not know that much about them. We need more research to understand what causes menstrual cycle disorders and how to cure them. In this article, you will learn about hormones, the menstrual cycle, what happens when the menstrual cycle does not function as planned, and how we can learn more about the fascinating female body.
A carbon footprint assessment for pasture-based dairy farming systems in South Africa
Authors: Galloway Craig , Swanepoel Pieter A. , Haarhoff Stephanus J.
Published: February 2024

Environmental impact evaluation of intensive dairy farming systems has been of growing interest recently as agriculture has several negative influences on the surrounding environment, including eutrophication, declines in biodiversity, and pollution of nearby waterbodies. Dairy production in particular is characterized by the emission of greenhouse gasses (GHG) contributing toward climate change. In this study, the carbon footprint of South African pasture-based dairy farming systems was assessed using a farm-gate life-cycle assessment (LCA) approach. A total of 82 pasture-based dairy farms across South Africa were assessed (2012–2022). The average carbon footprint across all dairy farming systems was 1.36 ± 0.21 kg CO2eq kg−1 fat- and protein-corrected milk produced (FPCM), which is higher than similar studies performed outside South Africa. Enteric fermentation had the largest influence on the carbon footprint, indicating the key role of methane as an emission source in ruminant dominated livestock systems. A difference in milk production efficiency was found between farming systems with the lowest and highest carbon footprints. Pasture-based dairy farming systems must be managed with adaptive management such as regenerative agriculture. Future research agendas should explore modeling approaches to assess the economic and environmental impact of dairy production, formulating a holistic understanding of the system dynamics while also quantifying net carbon emissions or sinks.
Ideal Weight and Weight Discrepancy: A Study of Life Course Trajectories and Intercohort Change in the Netherlands
Authors: Leopold Liliya
Published: February 2024

Objective: This study examined how individuals’ ideal weight and weight discrepancy (between ideal and actual weight) changed over the life course and across cohorts.

Methods: The study used population-representative longitudinal data collected in the Netherlands (N = 61,431 observations between 2007 and 2018 among N = 13,409 individuals aged 16 to 80 and born 1927–2000).

Results: Ideal weight increased linearly with age. Weight discrepancy showed a bell-shaped age pattern. Approximately half of the age-related increase in ideal weight was associated with concurrent increases in actual weight. Ideal weight and weight discrepancy increased slightly across cohorts. The cohort-related increase in ideal weight vanished after adjusting for change in actual weight. Analyses of population heterogeneity showed similar patterns of change in both outcomes across groups, although levels differed by gender, education, and migration status even after adjusting for differences in actual weight between these groups.

Conclusion: These results show that ideal weight and weight discrepancy in the Netherlands change substantially with age and modestly across cohorts. Potential explanations include changes in physical appearance and in the importance of physical appearance.
Ecotoxicological Effects of Commercial Microplastics on Earthworm Eisenia fetida (Savigny, 1826) (Clitellata; Lumbricidae)
Authors: Trakić Tanja , Popović Filip , Sekulić Jovana , Hackenberger Davorka K.
Published: February 2024

As soil invertebrates with a unique digestive system, earthworms are regularly used as bioindicators and test organisms. Due to their burrowing activity and casting, earthworms are involved in the structuring of the soil. However, this way of life exposes them to different pollutants, including microplastic particles. Although the use of plastics is economically justified, it has a major impact on living organisms. In this study, the influence of different concentrations (2.5%, 5%, and 7% (w/w)) of commercial glitter as a primary source of microplastics (MPs) on mortality, growth, cocoon production, avoidance behavior, and bioaccumulation ability during a four-week exposure of the earthworm species Eisenia fetida was investigated. The mortality was higher at 5% and 7% MPs in the soil than at 2.5% and in the control (0%) after 28 days, and the number of cocoons and growth rate decreased with an increasing MP concentration. However, the earthworms did not avoid the soil with MPs. Furthermore, the dissection of the digestive system enabled the identification of MP distribution. The sections of the digestive system were additionally examined under a fluorescence microscope. The results indicated that non-selective feeding enabled the input of MPs into the earthworm’s body and, thus, into food webs.
Potential of Cassava Clones for Iron, Zinc, and Selenium Biofortification
Authors: Inacio Karini Aparecida Matos , Farfan Nancy Carrasco , Azevedo Carlos Eduardo Xisto , Polatto Marco Antônio Gomes , Carrion Natã Souza , Mendes Polliany Vitória Santos , Mateus Nikolas Souza , Santos Elcio Ferreira
Published: February 2024

Cassava (Manihot esculenta Crantz) is a crucial staple food in South America, providing starchy storage roots that contribute to the sustenance of millions. To address deficiencies in iron (Fe), zinc (Zn), and selenium (Se), a global initiative is underway to identify plant species and genotypes that naturally accumulate these nutrients for human consumption, such as cassava. In this way, this study aims to identify potential cassava genotypes for biofortification in Fe, Zn, and Se, while also improving the overall cassava yield. We evaluated the accumulation potential of Fe, Zn, and Se in 20 South American cassava genotypes under traditional growing conditions, concurrently examining their photosynthetic and growth characteristics. Cassava roots exhibited Zn content ranging from 3.20 to 8.56 mg kg−1, Fe content from 2.20 to 10.73 mg kg−1, and Se content from 1.20 to 9.43 µg kg−1 (expressed on a dry basis). Genotypes MS018, DG014, and DG839 emerged as promising candidates for biofortification programs, displaying elevated levels of Fe, Zn, and Se, coupled with superior photosynthetic capacity. These genotypes, recommended for biofortification programs, also demonstrated increased yield potential. The findings from this study contribute to the development of cassava genotypes with enhanced agronomic biofortification and elevated yield potential.
Multifunctional Territorial Differentiation of Rural Production Spaces and Functional Zoning: A Case Study of Western Chongqing
Authors: Tang Yuhang , Liu Chunxia , Li Yuechen
Published: February 2024

With the continuous implementation of the rural revitalisation strategy, the social and economic landscape of China’s countryside has undergone significant changes and the structure and functions of rural production space have gradually become more complex and diversified. The theory of rural production space and its multifunctionality provides a new perspective for the study of rural human–land relationship patterns. Taking Western Chongqing, one of the national pilot zones for integrated urban–rural development, as an example, a scientific evaluation index system is established from the perspective of rural production space and its multifunctionality. The evaluation takes into account the consensus indicators of existing academic results, the regional characteristics of Western Chongqing, and relevant policies. On this basis, a regression model is constructed to investigate the factors influencing multifunctional regional differentiation, and a weighted clustering algorithm is used to classify the units in the study area into functional zones. The results of the study are as follows: (1) A multifunctional evaluation system with 24 indicators in five dimensions was constructed through the principle of scientific selection of indicators. (2) All functions in the rural production space of Western Chongqing have the respective geographical differentiation characteristics. In particular, the high-value and low-value agglomerations are generally distributed in strips or clusters, and the high-value and low-value agglomerations are intermingled, with each influencing factor driving the differentiation process of each function in the form of inhibition and reinforcement. (3) Western Chongqing can be divided into four types of functional areas: balanced development, lagging development–ecological recreation, urban development, and modern agriculture. Differentiated development strategies are proposed for different types of functional areas. We conclude that the study of the multifunctional spatial differentiation of rural production and functional zoning can provide a clearer analysis of the current status of rural development in Western Chongqing, and also enriches the perspective and methodology of the study of rural areas in western China.
Standardized Decision-Making for the Selection of Calf and Heifer Rearing Using a Digital Evaluation System
Authors: Regler Fredrik , Bernhardt Heinz
Published: February 2024

This study addresses the challenge of subjective remounting decisions in calf and heifer rearing, typically driven by the animal caretaker’s feelings and experience, lacking a robust data foundation. Key factors such as developmental delays, diseases, or rearing problems often go unnoticed or are forgotten due to the number of animals. To address this gap, an established state-of-the-art sensor network captures behavioral data during rearing, which is supplemented by manually collected data. This facilitates a novel decision network providing well-founded recommendations to the animal owner regarding whether to retain or cull an animal. The approach focuses on four key areas: colostrum supply, milk intake, weight development, and disease history during the rearing time of each individual, offering a transparent decision path for the use of each future cow. Introducing a standardized decision-making approach, the proposed approach enables an efficient, transparent, and targeted management strategy, contributing to the sustainable enhancement of the health and performance of calves and heifers. Additionally, it allows for the comparison of the growth trajectories of different animals over time. Notably, individual and transparent decisions can be made at each growth stage, enhancing the overall decision-making process in calf and heifer rearing.
Utilizing Remote Sensing to Quantify the Performance of Soybean Insecticide Seed Treatments
Authors: Hegstad Jeffrey M. , Mo Hua , Gaspar Adam P. , Rule Dwain
Published: February 2024

Soybean (Glycine max) is one of the most important oilseed crops grown in North America and a key contributor to the global protein supply. Insect feeding by a major soybean pest, the bean leaf beetle (BLB; Cerotoma trifurcata), can result in economic yield loss if not controlled. The objective of this research was to use unmanned aerial vehicle (UAV) image analysis to compare the agronomic and efficacy traits of two soybean insecticide seed treatments (IST) in locations with BLB feeding. Across the 2018–2023 field trial locations, 29 had low BLB feeding pressure (less than 25% feeding damage to no IST plots) and 31 had high BLB feeding pressure (greater than 25% feeding damage to no IST plots). In low BLB pressure locations, cyantraniliprole and imidacloprid seed treatments had significantly higher BLB efficacy, significantly higher UAV greenness, and significantly higher final yield as compared to no IST. In high BLB pressure locations, cyantraniliprole and imidacloprid seed treatments were significantly better compared to no IST for BLB efficacy, UAV emergence, UAV vigor, UAV greenness, and final yield. In high BLB pressure locations, cyantraniliprole had significantly higher BLB efficacy, significantly better UAV emergence, and significantly higher yield compared to imidacloprid. The cyantraniliprole treatment had a +254.5 kg/ha increase compared to no IST in low BLB pressure locations and a +213.7 kg/ha increase in high BLB pressure locations. The imidacloprid treatment had a +163.4 kg/ha yield increase compared to no IST in low BLB pressure locations and a +121.4 kg/ha yield increase in high BLB pressure locations. The use of UAV image analysis enabled quantification of the effect of BLB feeding on early-season agronomic traits and, when combined with efficacy and final yield data, successfully differentiated the performance of two soybean ISTs in environments with low or high insect pressure.
Machine Learning Techniques for Improving Nanosensors in Agroenvironmental Applications
Authors: Arellano Vidal Claudia Leslie , Govan Joseph Edward
Published: February 2024

Nanotechnology, nanosensors in particular, has increasingly drawn researchers’ attention in recent years since it has been shown to be a powerful tool for several fields like mining, robotics, medicine and agriculture amongst others. Challenges ahead, such as food availability, climate change and sustainability, have promoted such attention and pushed forward the use of nanosensors in agroindustry and environmental applications. However, issues with noise and confounding signals make the use of these tools a non-trivial technical challenge. Great advances in artificial intelligence, and more particularly machine learning, have provided new tools that have allowed researchers to improve the quality and functionality of nanosensor systems. This short review presents the latest work in the analysis of data from nanosensors using machine learning for agroenvironmental applications. It consists of an introduction to the topics of nanosensors and machine learning and the application of machine learning to the field of nanosensors. The rest of the paper consists of examples of the application of machine learning techniques to the utilisation of electrochemical, luminescent, SERS and colourimetric nanosensor classes. The final section consists of a short discussion and conclusion concerning the relevance of the material discussed in the review to the future of the agroenvironmental sector.
The Effect of Intracameral Triamcinolone Acetonide on Controlling Common Complications following Phacoemulsification in Dogs
Authors: Liu Zichen , Lu Di , Pang Mo , Li Jing , Liu Yue , Shi Hao , Liu Gang , Jin Yipeng
Published: February 2024

The intracameral injection of triamcinolone acetonide (TA) has achieved favorable clinical effects in controlling intraocular inflammatory reactions in humans after cataract surgery. However, the effect of this method remains unclear in veterinary practice. In this paper, 18 dogs with bilateral cataracts were randomly divided into three groups, with 6 dogs in each group. Phacoemulsification and intraocular lens implantation were performed on the 36 eyes of these dogs. A total of 0.1 mL of TA solution was injected into the oculus dexter (OD) anterior chambers. All oculus sinister (OS) anterior chambers of these dogs were used as controls. The results demonstrated that the corneal edema severity scores of the OD (1.5 mg TA) were lower than those of the OS from the 1st to 7th day after surgery, with a significant difference on the 3rd day after surgery (p = 0.033). The corneal edema severity scores in the OD (1.5 mg TA) were significantly lower than those in the OD (0.5 mg TA) on the 3rd day after surgery (p = 0.036). The aqueous humor protein concentration of the OD (1.5 mg TA) had a lower concentration than the OS on the 1st day after surgery (p = 0.004). Furthermore, on the 5th and 10th days, the aqueous humor protein concentration of the OD (1.5 mg TA) was lower than that of the OS (p = 0.038 and p = 0.044, respectively). The aqueous humor PGE2 concentration of the OD (1.5 mg TA) had a lower concentration than the OS on the 1st day after surgery (p = 0.026). The aqueous humor PGE2 concentrations in the OD (1.0 mg TA) and OD (1.5 mg TA) were lower compared to that in the OD (0.5 mg TA) on the 1st day after surgery (p = 0.041 and p = 0.037, respectively). It was demonstrated that TA-based treatment can be safely employed to effectively control common complications after phacoemulsification in dogs.