bluuebunny/crossref_metadata_2025 huggingface dataset:
The prognostic effect of tumor volume, reduction ratio, and cumulative doses on external beam radiotherapy with central-shielding method and image-guided adaptive brachytherapy for cervical cancer
Authors: Ohtaka Takeru , Ando Ken , Oike Takahiro , Noda Shin-ei , Kaminuma Takuya , Murata Kazutoshi , Ohno Tatsuya
Published: May 2024

Objective

To evaluate the prognostic effect of tumor volume at diagnosis, tumor reduction ratio during external beam radiotherapy (EBRT) with central-shielding method, and cumulative minimal dose to 90% of the high-risk clinical target volume (CTVHR D90) on combined EBRT and image-guided adaptive brachytherapy (IGABT) for cervical cancer.

Methods

Consecutive patients who underwent definitive radiotherapy or concurrent chemoradiotherapy for cervical cancer at Gunma University Hospital between January 2010 and December 2019 were retrospectively reviewed. Tumor volume at diagnosis and reduction ratio were calculated using magnetic resonance imaging at diagnosis and before the first IGABT session. The cumulative dose of EBRT and IGABT was calculated as an equivalent dose in 2 Gy fractions (EQD2). Optimal cutoff values were determined according to a receiver operating characteristic curve. Treatment outcomes were evaluated using the Kaplan–Meier method and compared using the log-rank test and Cox proportional hazards regression.

Results

A total of 254 patients were included in the analysis. The median follow-up for all patients was 57 (2–134) months. The 5-year overall survival (OS) was 81.9%, progression-free survival (PFS) was 71.3%, and local control (LC) was 94.5%. The patients were divided into four groups according to tumor volume at diagnosis and reduction ratio. The group with tumor volume at diagnosis ≥ 34.1 cm3 and reduction ratio < 68.8% showed significantly worse OS, PFS, and LC than the other three groups (All p < 0.05). In this group, the patients with a cumulative CTVHR D90 < 69.6 GyEQD2 showed significantly worse PFS and LC (p = 0.042 and p = 0.027, respectively). In the multivariate analysis of OS, adenocarcinoma/adenosquamous carcinoma, International Federation of Gynecology and Obstetrics 2009 stage III/IV, and a reduction ratio of < 68.8% were independent significant poor prognostic factors (p = 0.045, p = 0.009 and p = 0.001, respectively). In the univariate analysis of LC, a reduction ratio of < 68.8% was the only poor prognostic factor (p = 0.041).

Conclusion

The patients with large and poorly responding tumors had significantly worse prognoses in terms of OS, PFS, and LC, suggesting that dose escalation should be considered for such tumors.
Outcomes and patterns of use of Radium-223 in metastatic castration-resistant prostate cancer
Authors: Anido-Herranz Urbano , Fernandez-Calvo Ovidio , Ruiz-Bañobre Juan , Martinez-Breijo Sara , Fernandez-Nuñez Natalia , Nogareda-Seoane Zulema , Garrido-Pumar Miguel , Casas-Nebra Javier , Muñiz-Garcia Gloria , Portela-Pereira Paula , Gomez-Caamaño Antonio , Perez-Fentes Daniel Adolfo , Santome-Couto Lucia , Lázaro Martín , Molina-Diaz Aurea , Medina-Colmenero Ana , Vazquez-Estevez Sergio
Published: May 2024

Introduction

Radium-223 dichloride (Ra-223) is recommended as a treatment option for metastatic castration-resistant prostate cancer (mCRPC) patients with symptomatic bone metastases and no visceral disease, after docetaxel failure, or in patients who are not candidates to receive it. In this study, we aimed to ambispectively analyze overall survival (OS) and prognostic features in mCRPC in patients receiving Ra-223 as per clinical routine practice and identify the most suitable treatment sequence.

Patients and methods

This study is observational, multicentric, and ambispective. Eligibility criteria included mCRPC patients treated with Ra-223, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2, without visceral metastases, and no more than three cm involved lymph nodes.

Results

A total of 145 patients were included; the median age was 73.97 years, and a Gleason score of more than or equal to 7 in 61 (48%) patients; 73 (81%) had previously received docetaxel. The most important benefit was reached by those patients who received Ra-223 in the second-line setting, with a median OS of 17 months (95% CI, 12–21), and by patients who received six cycles of treatment, with a median OS of 19 months (95% CI, 14–21). An alkaline phosphatase (ALP) decrease was also identified as a prognosis marker. When performing the multivariate analysis, the time to develop castration-resistant disease longer than 24 months was the most important prognostic factor to predict the evolution of the patients receiving Ra-223. Ra-223 was well tolerated, with thrombocytopenia, anemia, and diarrhea being the main adverse events.

Conclusion

There is a benefit for those patients who received Ra-223 in the second-line setting, regardless of prior use of docetaxel. In addition, a survival benefit for patients presenting with a decline in ALP was observed.
The relationship between attitude toward physical activity and weight gain in children and young adolescence
Authors: Özer Ömer , Uyhan Osman , Devrilmez Erhan , Orhan İlkay , Bilgiç Mert , Uğurlu Alkan , Tabak Ekrem Yasin , Yüksel Oğuzhan , Şentürk Aydın , Karakullukçu Ayla , Eler Nebahat , Özcan Kürşat , Akpınar Selçuk
Published: May 2024

Introduction

The purpose of this study was to investigate the association between attitudes toward physical activity and weight gain among children and young adolescents with an additional focus on the impact of gender on these attitudes.

Methods

Employing a descriptive survey method, data were systematically gathered via purposive sampling from 11 specific cities in Türkiye, ensuring representation from all seven regions. A total of 3,138 students, aged between 9 and 14 years, participated in this study, with a distribution of 46% girls and 54% boys. To assess the attitudes of children and young adolescents toward physical activity, the Youth Physical Activity Attitude Scale was utilized. Height and body weight measurements were taken to determine the body mass index of participants. SPSS 26.0 software facilitated the statistical analyses, including Pearson correlation analysis to explore relationships between variables. Multivariate Analysis of Variance was employed to evaluate the impact of age, BMI, and gender on attitudes toward physical activity.

Results

Participants classified as normal weight exhibited a more positive attitude towards physical activity compared to their obese and overweight counterparts. Moreover, a significant gender difference emerged, with boys demonstrating significantly higher positive attitudes toward physical activity than girls. However, no significant difference was observed in negative attitudes based on gender. The study also revealed that an escalation in negative attitudes towards physical activity correlated with students being categorized as underweight, overweight, or obese, as opposed to having a normal weight status. Additionally, a statistically significant divergence in both positive and negative attitudes towards physical activity was found based on age. Specifically, the results indicated that students aged 9 and 14 exhibited lower levels of positive attitude when contrasted with their counterparts of different age groups. Conversely, in the domain of negative attitudes, students at the age of 9 scored higher than their peers in other age categories.

Discussion

Attitudes towards physical activity can serve as a convenient indicator and guide for assessing the effectiveness of various practices or interventions aimed at promoting physical activity, with recognition of the significant gender difference in positive attitudes among children and young adolescents.
Enhancing surgical planning for abdominal tumors in children through advanced 3D visualization techniques: a systematic review of future prospects
Authors: Lopez Pauline , Belgacem Alexis , Sarnacki Sabine , Arnaud Alexis , Houari Jenna , Piguet Christophe , Baudouin Maxime , Fourcade Laurent , Lauvray Thomas , Ballouhey Quentin
Published: May 2024

Introduction

Preoperative three-dimensional (3D) reconstruction using sectional imaging is increasingly used in challenging pediatric cases to aid in surgical planning. Many case series have described various teams' experiences, discussing feasibility and realism, while emphasizing the technological potential for children. Nonetheless, general knowledge on this topic remains limited compared to the broader research landscape. The aim of this review was to explore the current devices and new opportunities provided by preoperative Computed Tomography (CT) scans or Magnetic Resonance Imaging (MRI).

Methods

A systematic review was conducted to screen pediatric cases of abdominal and pelvic tumors with preoperative 3D reconstruction published between 2000 and 2023.

Discussion

Surgical planning was facilitated through virtual reconstruction or 3D printing. Virtual reconstruction of complex tumors enables precise delineation of solid masses, formulation of dissection plans, and suggests dedicated vessel ligation, optimizing tissue preservation. Vascular mapping is particularly relevant for liver surgery, large neuroblastoma with imaging-defined risk factors (IDRFs), and tumors encasing major vessels, such as complex median retroperitoneal malignant masses. 3D printing can facilitate specific tissue preservation, now accessible with minimally invasive procedures like partial nephrectomy. The latest advancements enable neural plexus reconstruction to guide surgical nerve sparing, for example, hypogastric nerve modelling, typically adjacent to large pelvic tumors. New insights will soon incorporate nerve plexus images into anatomical segmentation reconstructions, facilitated by non-irradiating imaging modalities like MRI.

Conclusion

Although not yet published in pediatric surgical procedures, the next anticipated advancement is augmented reality, enhancing real-time intraoperative guidance: the surgeon will use a robotic console overlaying functional and anatomical data onto a magnified surgical field, enhancing robotic precision in confined spaces.
Developing and validating a nomogram for early predicting the need for intestinal resection in pediatric intussusception
Authors: Yu Yuan-Yang , Zhang Jia-Jie , Xu Ya-Ting , Lin Zheng-Xiu , Guo Shi-Kun , Li Zhong-Rong , Huang Hui-Ya , Huang Xiao-Zhong
Published: May 2024

Purpose

Develop and validate a nomogram for predicting intestinal resection in pediatric intussusception suspecting intestinal necrosis.

Patients & methods

Children with intussusception were retrospectively enrolled after a failed air-enema reduction in the outpatient setting and divided into two groups: the intestinal resection group and the non-intestinal resection group. The enrolled cases were randomly selected for training and validation sets with a split ratio of 3:1. A nomogram for predicting the risk of intestinal resection was visualized using logistic regression analysis with calibration curve, C-index, and decision curve analysis to evaluate the model.

Results

A total of 547 cases were included in the final analysis, of which 414 had non-intestinal necrosis and 133 had intestinal necrosis and underwent intestinal resection. The training set consisted of 411 patients and the validation cohort included 136 patients. Through forward stepwise regression, four variables (duration of symptoms, C-reaction protein, white blood cells, ascites) were selected for inclusion in the nomogram with a concordance index 0.871 (95% confidence interval: 0.834–0.908).

Conclusion

We developed a nomogram for predicting intestinal resection in children with intussusception suspecting intestinal necrosis after a failed air-enema based on multivariate regression. This nomogram could be directly applied to facilitate predicting intestinal resection in pediatric intussusception suspecting necrosis.
Response analysis of Pinus sibirica to pine wood nematode infection through transcriptomics and metabolomics study
Authors: Zhang Jiawei , Ye Lingfang , Chen Qiaoli , Wang Feng
Published: May 2024

Pinus sibirica is primarily distributed in Siberia. Owing to its excellent cold resistance and development potential, it has become an important introduced tree species in the Greater Xing’an area of China. Pine wilt disease, triggered by the pine wood nematode (PWN, Bursaphelenchus xylophilus), constitutes a profoundly critical affliction within forest ecosystems. Its incidence has extended to the northeastern region of China in recent years. To explore the potential host status of P. sibirica in the Greater Xing’an area for PWN and to elucidate the responses following inoculation, artificial inoculation, transcriptomics, and metabolomics methods were used. In the artificial inoculation experiments, quantitative analysis of nematode populations within the trees demonstrated that PWN exhibited normal growth and reproductive capabilities within P. sibirica. Subsequently, transcriptome and metabolome sequencing were conducted at four time points before disease onset (3-, 5-, 7-, and 9-days post inoculation). Gene trend analysis and differentially expressed gene screening were employed and the results indicated that genes associated with the flavonoid biosynthesis pathway exhibited predominant enrichment among the up-regulated genes. Metabolome analysis showed that the abundance of flavonoid-related metabolites in P. sibirica increased after inoculation with PWN. Integrated analysis of transcriptome and metabolome revealed that after PWN inoculation in P. sibirica, two chalcone synthase (chs) genes and a chalcone isomerase (chi) gene were significantly upregulated, and the upregulation should accumulate naringenin, pinocembrin, and apigenin to help P. sibirica resist infection of PWN. The results suggested that flavonoid biosynthesis pathway continued to respond after P. sibirica was infected with PWN and played an important role in the interaction between P. sibirica and PWN.
Internet-based self-administered intervention to reduce anxiety and depression symptomatology and improve well-being in 7 countries: protocol of a randomized control trial
Authors: Dominguez-Rodriguez Alejandro , Herdoiza-Arroyo Paulina Erika , González-Ramírez Leivy Patricia , Martínez-Arriaga Reyna Jazmín , Villarreal-Zegarra David , Santos da Silva Antonio Carlos , González-Cantero Joel Omar , Vargas Salinas Viviana Sylvia , S. Mensorio Marinna , Cisneros Hernández Adrián Antonio , Lourenço dos Santos Rogéria , Nieto Ramos Emilia Gabriela , Albán-Terán Margarita Gabriela , Mateu-Mollá Joaquín , Ramírez-Martínez Flor Rocío , Colmenero Guadián Ana Marisa , Martínez-Rubio David , Langer Álvaro I. , Araya Claudio , Castellanos-Vargas Rosa Olimpia
Published: May 2024

Background

Online psychological interventions have emerged as a treatment alternative because they are accessible, flexible, personalized, and available to large populations. The number of Internet interventions in Latin America is limited, as are Randomized Controlled Trials (RCTs) of their effectiveness and a few studies comparing their effectiveness in multiple countries at the same time. We have developed an online intervention, Well-being Online, which will be available to the public free of charge in 7 countries: Mexico, Ecuador, Peru, Chile, Brazil, Spain, and the Netherlands. We expect a reduction in depression and anxiety symptoms and an increase in well-being of the participants.

Methods

A multi-country, randomized controlled trial will be conducted. The intervention is multicomponent (Cognitive Behavioral Therapy, Behavioral Activation Therapy, Mindfulness, Acceptance and Commitment Therapy, and Positive Psychology), with 10 sessions. In each country, eligible participants will be randomized to one of three groups: Enriched Intervention (interactive web design with videos, infographics, text, audio, and forum), Text Intervention (text on the website), and Wait List (control group). Repeated measures will be obtained at 5-time points. Our primary outcomes will be anxiety symptomatology, depressive symptomatology, and mental well-being. MANOVA analysis will be used for our main analysis.

Discussion

This protocol describes the design of a randomized trial to evaluate the efficacy of a web-based intervention to reduce anxiety and depression symptomatology and increase subjective well-being. The intervention will be made available in four languages (Spanish, Portuguese, Dutch, and English). Its results will contribute to the evidence of effectiveness in terms of randomized trials and Internet interventions, mainly in Latin America and Europe.
A study on the double-edged sword effect of inclusive leadership on employees’ work behaviour—dual path perspective of cognition and affection
Authors: Chen Hao , Bao Jiaying , Wang Liang , Zhang Zihan
Published: May 2024

In order to cope with the volatile social environment and organisational change, more and more scholars call on leaders to stimulate subordinate effectiveness to a greater extent with inclusive behaviour. Existing studies focus on the positive impact of inclusive leadership, but ignore its potential negative impact. This study integrates Cognition-affection Personality System Theory to explore the double-edged sword mechanism of inclusive leadership on subordinates’ work behaviour. Through the data analysis of 518 paired questionnaires collected in three stages, the results are as follows: Inclusive leadership has a positive impact on subordinates’ psychological entitlement and state gratitude; Psychological entitlement and state gratitude play mediation roles not only between inclusive leadership and work withdrawal behaviour, but also between inclusive leadership and active behaviour; Subordinate narcissistic personality moderates the positive effect of inclusive leadership on psychological entitlement and state gratitude, and then moderates the indirect effect of inclusive leadership on subordinate work withdrawal behaviour and proactive behaviour through psychological entitlement and state gratitude. The above results expand the research on the action mechanism and boundary conditions of inclusive leadership in Chinese organisational context, and provide practical guidance for organisational managers to effectively conduct inclusive leadership.
The psychological implications of COVID-19 over the eighteen-month time span following the virus breakout in Italy
Authors: Ropi Ingrid , Lillo Margherita , Malavasi Matteo , Argentieri Alessandro , Barbieri Aurora , Lou Baowen , Barbieri Diego Maria , Passavanti Marco
Published: May 2024

Background

In a short time, the COVID-19 pandemic has exerted a huge impact on many aspects of people’s lives with a number of consequences, an increase in the risks of psychological diseases being one of them. The aim of this experimental study, based on an eighteen-month follow-up survey, is to assess the psychological effects of the COVID-19 pandemic, in particular, changes in stress, anxiety and depression levels, and the risks of developing Post-Traumatic Stress Disorder (PTSD).

Methods

A follow-up survey was performed on a sample of 184 Italian individuals to collect relevant information about the psychological impact of COVID-19. Predictors of the components of the psychological impact were calculated based on the ANCOVA model.

Results

The analysis of the online questionnaires led to the conclusion that a high percentage of the participants suffer from levels of stress, anxiety and depression higher than normal as well as an increased risk of PTSD. The severity of such disorders significantly depends on gender, the loss of family members or acquaintances due to the pandemic, the amount of time spent searching for COVID-19 related information, the type of information sources and, in part, on the level of education and income. The time factor had a more severe effect on the low-income population.

Conclusion

COVID-19 has entailed a very strong psychological impact on the Italian population also depending on the coping strategies adopted, the level of mindful awareness, socio-demographic variables, people’s habits and the way individuals use the available means of communication and information.
The bidirectional relationship between sarcopenia and disability in China: a longitudinal study from CHARLS
Authors: Liu Li , Zhang Yan , Shi Yan , Wu Lanxin , Meng Lixue , Zhao Ting
Published: May 2024

Objectives

Sarcopenia and disability represent significant concerns impacting the health of older people. This study aimed to explore the bidirectional relationship between sarcopenia and disability in Chinese older people.

Methods

This study recruited older people ≥60 years old from the China Health and Retirement Longitudinal Study. In phase I, the study analyzed the relation between disability and subsequent sarcopenia using multinomial logistic regression models. Conversely, in phase II, the study assessed whether sarcopenia was associated with future disability using binary logistic regression models.

Results

In phase I, 65 (16.80%) new cases of possible sarcopenia, 18 (4.65%) cases of sarcopenia, and 9 (2.33%) cases of severe sarcopenia were observed in the disabled older people and 282 (10.96%) new cases of possible sarcopenia, 97 (3.77%) cases of sarcopenia, 35 (1.36%) cases of severe sarcopenia were observed in the older people without disability. The OR (95% CI) for sarcopenia in older disabled individuals compared to those without disability was 1.61 (1.25–2.07). Adjusting for all covariates in 2011, the OR (95% CI) value for disabled individuals vs. those without disability was 1.35 (1.02–1.79). Subgroup analyses showed that disabled participants aged < 80 years were more likely to have sarcopenia (OR = 1.42, 95% CI: 1.07–1.89), and the risk of sarcopenia did not differ significantly between sex subgroups. In phase II, 114 cases (33.83%) in the possible sarcopenia patients, 85 cases (28.91%) in the sarcopenia patients, 23 cases (35.94%) in the severe sarcopenia patients, and 501 cases (16.10%) in the individuals without sarcopenia showed symptoms of disability. The OR (95% CI) for disability was 2.66 (2.08–3.40) in the possible sarcopenia patients, 2.12 (1.62–2.77) in the sarcopenia patients, and 2.92 (1.74–4.91) in the severe sarcopenia patients compared with the no sarcopenia patients. After adjusting for all covariates in 2011, the OR (95% CI) values were 2.21 (1.70–2.85) in the possible sarcopenia patients, 1.58 (1.14–2.19) in the sarcopenia patients, and 1.99 (1.14–3.49) in the severe sarcopenia patients, as compared to the older people without sarcopenia. Subgroup analyses showed that compared with men, women with possible sarcopenia had a higher risk of disability (OR = 2.80, 95% CI: 1.98–3.97). In addition, participants aged < 80 years with sarcopenia or severe sarcopenia s were more likely to have disability (OR = 2.13, 95% CI: 1.52–2.98; OR = 2.98, 95% CI: 1.60–5.54).

Conclusion

The occurrence of disability increase the risk of sarcopenia in the older people, and baseline sarcopenia predicts the future disability in older people.
“The perfect storm”: community worker perspectives on the impact of COVID-19 on New York City immigrants and migrant-serving organizations
Authors: Hobbs L. Ansley , Masoud Dima , Cravero Kathleen , Figueroa Elisabeth Manipoud , Romero Diana
Published: May 2024

Background

Immigrants in New York City (NYC) have higher COVID-19 mortality than the general population. While migrant-serving organizations (MSOs) provide access to a breadth of services, they are disproportionately impacted by the COVID-19 pandemic due to staffing limitations, funding cuts, and resource limitations of communities served.

Methods

Six focus-group discussions were conducted to explore the experiences of MSOs in NYC during the COVID-19 pandemic from November 2021 to March 2022. Study participants csomprised a subsample of survey respondents from a larger study identified via lists of MSOs.

Results

Twenty-seven organizational representatives from 11 MSOs across NYC participated in the discussions. In addition to providing information on communities served, services offered, and organizational characteristics, the following themes emerged from the convenings: mental health challenges and resources needed for immigrants; immigration-related challenges; factors exacerbating hardships for immigrants during COVID-19; interorganizational collaborations and partnerships; policy change; and needs/requests of MSOs. MSOs provide a wide range of services as non-profit organizations and use interorganizational collaboration to improve service delivery. The proximity of MSOs to immigrant communities helps providers understand the needs of immigrants relating to the COVID-19 pandemic and factors that shape telehealth services.

Conclusion

MSOs are important providers and advocates for immigration policy in the US given their relationship with the populations they serve. These findings have implications for how to support MSOs that serve immigrants in NYC. Strategies to achieve this include timelier availability and exchange of information, policies, and research as well as strengthening the experience-based advocacy of these groups.
Innova4Health: an integrated approach for prevention of recurrence and personalized treatment of Major Depressive Disorder
Authors: Monaco Francesco , Vignapiano Annarita , Piacente Martina , Farina Federica , Pagano Claudio , Marenna Alessandra , Leo Stefano , Vecchi Corrado , Mancuso Carlo , Prisco Vincenzo , Iodice Davide , Auricchio Annarosaria , Cavaliere Roberto , D'Agosto Amelia , Fornaro Michele , Solmi Marco , Corrivetti Giulio , Fasano Alessio
Published: May 2024

Background

Major Depressive Disorder (MDD) is a prevalent mental health condition characterized by persistent low mood, cognitive and physical symptoms, anhedonia (loss of interest in activities), and suicidal ideation. The World Health Organization (WHO) predicts depression will become the leading cause of disability by 2030. While biological markers remain essential for understanding MDD's pathophysiology, recent advancements in social signal processing and environmental monitoring hold promise. Wearable technologies, including smartwatches and air purifiers with environmental sensors, can generate valuable digital biomarkers for depression assessment in real-world settings. Integrating these with existing physical, psychopathological, and other indices (autoimmune, inflammatory, neuroradiological) has the potential to improve MDD recurrence prevention strategies.

Methods

This prospective, randomized, interventional, and non-pharmacological integrated study aims to evaluate digital and environmental biomarkers in adolescents and young adults diagnosed with MDD who are currently taking medication. The study implements a sensor-integrated platform built around an open-source “Pothos” air purifier system. This platform is designed for scalability and integration with third-party devices. It accomplishes this through software interfaces, a dedicated app, sensor signal pre-processing, and an embedded deep learning AI system. The study will enroll two experimental groups (10 adolescents and 30 young adults each). Within each group, participants will be randomly allocated to Group A or Group B. Only Group B will receive the technological equipment (Pothos system and smartwatch) for collecting digital biomarkers. Blood and saliva samples will be collected at baseline (T0) and endpoint (T1) to assess inflammatory markers and cortisol levels.

Results

Following initial age-based stratification, the sample will undergo detailed classification at the 6-month follow-up based on remission status. Digital and environmental biomarker data will be analyzed to explore intricate relationships between these markers, depression symptoms, disease progression, and early signs of illness.

Conclusion

This study seeks to validate an AI tool for enhancing early MDD clinical management, implement an AI solution for continuous data processing, and establish an AI infrastructure for managing healthcare Big Data. Integrating innovative psychophysical assessment tools into clinical practice holds significant promise for improving diagnostic accuracy and developing more specific digital devices for comprehensive mental health evaluation.
Immediate loading in partially edentulous patients with fixed implant-supported restorations cases report
Authors: Wang Shuang , Duan Siyi , Chen Rui , Wang Zijian , Tang Yulong
Published: May 2024

Objectives

This article reports on four rare cases involving multiple trauma-induced adjacent missing anterior teeth in the maxillary or mandibular region. These cases were successfully treated using a 4-axial implant-based alternative insert and an immediate loading protocol.

Material and methods

This series of cases was summarized by retrospective study that 4 patients who received a total of 20 immediately loaded implants. These patients had suffered from trauma-induced loss of 8–9 adjacent anterior teeth. The 4-axial-implants were inserted with the assistance of digital pioneer drill guides. The surgical procedure involved alveolar bone trimming or ultrasonic osteotomy, eliminating the need for traditional large-area bone augmentation. Pre- and post-operative CBCT was matched using DTX Studio Implant software, the deviation of implant between actual position and preoperative design was measured and compared using SPSS software package.

Results

The average follow-up duration 48 months after implant prostheses, the cumulative retention rate of the implants was 100%, the marginal bone loss averaged 0.53 mm (SD 0.15 mm), and buccal plate bone loss averaged 0.62 mm (SD 0.41 mm).

Conclusions

This retrospective clinical report demonstrates the successful treatment of several patients with multiple adjacent maxillary or mandibular anterior teeth using four implant-supported screws to fix the frame and employing immediate loading. The approach resulted in long-term stable clinical outcomes. Moreover, the method not only shortens the period of edentulism but also facilitates easy disassembly, maintenance, and cleaning. Consequently, it emerges as a highly favorable clinical option for patients suffering from extensive tooth loss.
Rise of remote work across borders: opportunities and implications for migrant-sending countries
Authors: Mieriņa Inta , Šūpule Inese
Published: May 2024

Contact restrictions imposed during the COVID-19 pandemic have contributed to the rapid expansion of remote work. With this expansion, new opportunities arise for the typical migrant-sending countries in Central and Eastern Europe to remotely involve their diaspora in their labor market. The aim of this paper is, by using the case study of Latvia, to show the potential of cross-border remote work for alleviating human capital losses caused by emigration. We assess the main obstacles and necessary adjustments in taxes, social benefits, labor market regulation and other areas to facilitate the labor market transition and show what incentives the country can use to become a place of choice for performing remote work for the diaspora. Combining the perspectives of employers, employees and the government, this study sheds new light on the challenges and opportunities related to the rise of remote work for countries suffering from emigration. The comprehensive analysis builds on triangulating secondary data, analysis of policy documents, a survey of employers, as well as a survey and in-depth interviews with cross-border remote workers.
Impact of dioxins on reproductive health in female mammals
Authors: Aldeli Nour , Murphy Denis , Hanano Abdulsamie
Published: May 2024

Extensive research has been conducted to investigate the toxicological impact of dioxins on mammals, revealing profound effects on the female reproductive system in both humans and animals. Dioxin exposure significantly disrupts the intricate functions of the ovary, a pivotal organ responsible for reproductive and endocrine processes. This disruption manifests as infertility, premature ovarian failure, and disturbances in sex steroid hormone levels. Comprehensive studies, encompassing accidental human exposure and experimental animal data, have raised a wealth of information with consistent yet varied conclusion influenced by experimental factors. This review begins by providing an overarching background on the ovary, emphasizing its fundamental role in reproductive health, particularly in ovarian steroidogenesis and hormone receptor regulation. Subsequently, a detailed examination of the Aryl hydrocarbon Receptor (AhR) and its role in governing ovarian function is presented. The review then outlines the sources and toxicity of dioxins, with a specific focus on AhR involvement in mediating reproductive toxicity in mammals. Within this context, the impact of dioxins, notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on Folliculogenesis and Preimplantation embryos is discussed. Furthermore, the review delves into the disruptions of the female hormonal system caused by TCDD and their ramifications in endometriosis. Notably, variations in the effects of TCDD on the female reproductive and hormonal system are highlighted in relation to TCDD dose, animal species, and age. As a forward-looking perspective, questions arise regarding the potential involvement of molecular mechanisms beyond AhR in mediating the female reproductive toxicity of dioxins.
Prevalence and appropriateness of omeprazole prescription in dogs at a veterinary teaching hospital before and after the publication of the ACVIM consensus statement on the rational administration of gastrointestinal protectants
Authors: Sainz Ángel , García-Sancho Mercedes , Villaescusa Alejandra , Rodríguez-Franco Fernando , Díaz-Regañón David , Olmeda Patricia , Marks Stanley L.
Published: May 2024

Introduction

Overprescribing of acid suppressants is a common phenomenon in human and small animal patients, leading to potential deleterious gastrointestinal (GI) and non-GI consequences. The impact of consensus statements on veterinary prescribing habits in clinical practice have not been fully evaluated. This study aimed to compare the prescribing habits of the proton pump inhibitor (PPI), omeprazole, in dogs in an academic veterinary teaching hospital before and after the publication of the American College of Veterinary Internal Medicine (ACVIM) consensus statement on rational use of gastrointestinal protectants.

Methods

Evaluation of the prescribing habits of omeprazole in dogs during the years 2017 and 2021 was retrospectively compared. These years were selected to reflect a 12-month period prior to and following the publication of the consensus statement. One hundred dogs from each year were randomly selected. Dose, frequency of administration, duration of treatment, concurrent prescription of more than one gastroprotectant and indications for prescribing omeprazole were analyzed.

Results

A significant increase in the cases that received omeprazole q12h (p < 0.0001) or that underwent a tapering dose after ≥4 week-therapy (p > 0.0001) was detected after the publication of the 2018 ACVIM consensus statement. Considering the indications, there was also a significant increase in the appropriate prescription of omeprazole in the second compared to the first period of study (p < 0.0001). Fifteen of 16 clinicians (94%) involved in the prescription of omeprazole indicated that their reading of the consensus statement had changed their clinical practice regarding PPI administration in dogs.

Discussion

These results support the beneficial impact of the ACVIM consensus statement on the judicious prescribing of omeprazole in an academic veterinary hospital. These results should not be extrapolated to first-opinion veterinary practices, and further efforts should be made to ensure that PPIs are prescribed prudently with a clear indication and regular review of the appropriateness of continued administration to minimize possible risks and adverse drug interactions.
Application of imaging and spectroscopy techniques for grading of bovine embryos - a review
Authors: Shivaani Manickavasagan , Madan Pavneesh
Published: May 2024

Although embryo transfers have grown considerably in the cattle industry, the selection of embryos required for successful pregnancies remains a challenging task. Visual inspection of 7th-day embryos using a stereomicroscope, followed by classification based on morphological features is the most commonly practiced procedure. However, there are inaccuracies and inconsistencies in the manual grading of bovine embryos. The objective of this review was to evaluate the potential of imaging and spectroscopic techniques in the selection of bovine embryos. Digital analysis of microscopic images through extracting visual features in the embryo region, and classification using machine learning methods have yielded about 88–96% success in pregnancies. The Raman spectral pattern provides valuable information regarding developmental stages and quality of the embryo. The Raman spectroscopy approach has also been successfully used to determine various parameters of bovine oocytes. Besides, Fourier Transform Infrared (FTIR) spectroscopy has the ability to assess embryo quality through analyzing embryo composition, including nucleic acid and amides present. Hyperspectral Imaging has also been used to characterize metabolite production during embryo growth. Although the time-lapse imaging approach is beneficial for morphokinetics evaluation of embryo development, optimized protocols are required for successful implementation in bovine embryo transfers. Most imaging and spectroscopic findings are still only at an experimental stage. Further research is warranted to improve the repeatability and practicality to implement in commercial facilities.
Women Are Also Disadvantaged in Accessing Transplant Outside the United States: Analysis of the Spanish Liver Transplantation Registry
Authors: Tejedor Marta , Neria Fernando , De La Rosa Gloria , Almohalla Álvarez Carolina , Padilla María , Boscà Robledo Andrea , Fundora Suárez Yiliam , Sánchez-Bueno Francisco , Gómez-Bravo Miguel Angel , Berenguer Marina
Published: May 2024

Sex inequities in liver transplantation (LT) have been documented in several, mostly US-based, studies. Our aim was to describe sex-related differences in access to LT in a system with short waiting times. All adult patients registered in the RETH-Spanish Liver Transplant Registry (2000–2022) for LT were included. Baseline demographics, presence of hepatocellular carcinoma, cause and severity of liver disease, time on the waiting list (WL), access to transplantation, and reasons for removal from the WL were assessed. 14,385 patients were analysed (77% men, 56.2 ± 8.7 years). Model for end-stage liver disease (MELD) score was reported for 5,475 patients (mean value: 16.6 ± 5.7). Women were less likely to receive a transplant than men (OR 0.78, 95% CI 0.63, 0.97) with a trend to a higher risk of exclusion for deterioration (HR 1.17, 95% CI 0.99, 1.38), despite similar disease severity. Women waited longer on the WL (198.6 ± 338.9 vs. 173.3 ± 285.5 days, p < 0.001). Recently, women’s risk of dropout has reduced, concomitantly with shorter WL times. Even in countries with short waiting times, women are disadvantaged in LT. Policies directed at optimizing the whole LT network should be encouraged to guarantee a fair and equal access of all patients to this life saving resource.
Performance-Constraint Fault Tolerant Control to Aircraft in Presence of Actuator Deviation
Authors: Tang Peng , Zhao Chuangxin , Liang Shizhe , Dai Yuehong
Published: May 2024

Accuracy of electro-mechanical actuator in aircraft is susceptible to variable operation conditions such as electromagnetic interference, changeable temperature or loss of maintenance, leading in turn to flight performance degradation. This paper proposed an unified control paradigm that aims to keep aircraft’s velocity in a safe boundary and shorten the system stabilizing time in presence of actuator deviation. The controller is derived following a practical finite-time-convergence (FTC) with extended dynamics, and an integrated state-constraint structure so as to restrict air vehicle’s attitude rate or translation velocity. It is proved that the system state converges to a sphere near the origin in a finite time, the state trajectory is always remain within the prescribed range, and all signals of the closed-loop system are uniformly ultimately bounded. Compared simulation with the quadratic Lyapunov-based FTC method and an asymptotic convergence controller are conducted on an unmanned helicopter prototype. Results show that the proposed controller enhances the dynamic and fault-tolerant performance of resisting actuator fluctuation.
Differences in Exercise Stress, Job Satisfaction, Intention to Quit Exercise, and Quality of Life According to the Psychological Abuse Experiences of Elite Male Athletes
Authors: Jun Mun-Gyu , Kim Soon-Young
Published: May 2024

This study aimed to further understand psychological abuse in sports and contribute to the development of elite sports and athletes’ persistent performance by identifying the causal effects of psychological abuse on elite athletes’ exercise stress, job satisfaction, intention to quit exercise, and quality of life (QOL). Data were collected from 363 elite South Korean male athletes (ages ≥ 20 years) from August to September 2023. The independent variable for comparative analysis was the presence or absence of psychological abuse in elite male athletes by coaches. The participants were divided into two groups: a non-abuse-experienced group (Group 1) and an abuse-experienced group (Group 2). Participants’ demographic and athletic background information (e.g., career and sport) were also collected. This study showed that the three factors (exercise stress, intention to quit exercise, and QOL) were higher in Group 2 than in Group 1. These findings provide a meaningful analysis of the impact of psychological abuse on the mental health, persistence, and overall QOL of elite male athletes that can be used to develop countermeasures and policies against psychological abuse that threatens the mental health of elite athletes.
Is Online Technology the Hope in Uncertain Times for Higher Education?
Authors: Picciano Anthony G.
Published: May 2024

Significant technological challenges are affecting societies across the world and online technology continues to assume a pivotal place in all organizations: commercial and non-commercial, governmental and non-governmental, and all forms of education [...]
Exploration of Eye Fatigue Detection Features and Algorithm Based on Eye-Tracking Signal
Authors: Sun Weifeng , Wang Yuqi , Hu Bingliang , Wang Quan
Published: May 2024

Eye fatigue has a fatiguing effect on the eye muscles, and eye movement performance is a macroscopic response to the eye fatigue state. To detect and prevent the risk of eye fatigue in advance, this study designed an eye fatigue detection experiment, collected experimental data samples, and constructed experimental data sets. In this study, eye-tracking feature extraction was completed, and the significance difference of eye-tracking features under different fatigue states was discussed by two-way repeated-measures ANOVA (Analysis of Variance). The experimental results demonstrate the feasibility of eye fatigue detection from eye-tracking signals. In addition, this study considers the effects of different feature extraction methods on eye fatigue detection accuracy. This study examines the performance of machine learning algorithms based on manual feature calculation (SVM, DT, RM, ET) and deep learning algorithms based on automatic feature extraction (CNN, auto-encoder, transformer) in eye fatigue detection. Based on the combination of the methods, this study proposes the feature union auto-encoder algorithm, and the accuracy of the algorithm for eye fatigue detection on the experimental dataset is improved from 82.4% to 87.9%.
Study on the Impact of Tail Wing Profiles on the Resistance Characteristics of Amphibious Vehicles
Authors: Jiang Zhongyuan , Ding Jiangming , Li Zhourui
Published: May 2024

The resistance performance of amphibious vehicles can be improved by installing underwater tail hydrofoils. The research on the impact of different hydrofoil profiles on the resistance characteristics of amphibious vehicles can provide a reference for the vehicle’s design. For an amphibious vehicle model, five shapes of symmetrical hydrofoils, NACA0012, NACA0015, NACA0016, and asymmetric hydrofoils NACA23012, NACA66-209, were selected as the underwater tail wing of the vehicle body, respectively. Based on the RANS method and overset grid technology, the resistance performance of the vehicle body was numerically calculated, and the resistance variation in the amphibious vehicle equipped with different tail hydrofoils at 0.43 < Fr∇ < 1.3 speed was obtained. The basic shape of amphibious vehicle tail wings can be determined by comparing the effects of symmetrical hydrofoils and asymmetric hydrofoils on body resistance. The results show that the asymmetric hydrofoils have a better resistance reduction effect on amphibious vehicles than the symmetrical ones. Among them, an amphibious vehicle installing the asymmetric hydrofoil NACA66-209 as an underwater tail wing can reduce resistance by 44.3%. Chord length is an important factor affecting the resistance reduction performance of tail wings. When Fr∇ = 1.3, the asymmetric hydrofoil optimized based on chord length has a 21.2% higher resistance reduction effect on amphibious vehicles.
Tillage and Straw Management Practices Influences Soil Nutrient Distribution: A Case Study from North-Eastern Romania
Authors: Calistru Anca Elena , Filipov Feodor , Cara Irina Gabriela , Cioboată Marius , Țopa Denis , Jităreanu Gerard
Published: May 2024

Tillage practices govern crop quality and quantity through soil nutrient availability and crop root systems. A deeper knowledge of the impact of conservation tillage on soil chemical characteristics (such as pH, soil organic carbon, macro and micronutrient storage and distribution) is required for both the promotion of agricultural sustainability and environmental preservation. This study assesses the changes in soil features and properties in the context of a long-field experiment with different tillage systems and straw management practices. Research findings revealed that compared with conventional tillage (CT) conservative tillage with partial straw retention (MT) and no-tillage with straw mulching (NT) substantially boosted the organic carbon (OC) (by 6–19%), total nitrogen (TN) (by 2–12%), and available potassium content (AK) (by 2–5%), in 0–30 cm soil depth. However, the stratification trend was observed for available macro and micronutrient content (Zn, Fe, Mn) in both conservative management practices. The concentration of Cu indicates a constant pattern through a 0–30 cm soil profile with a higher concentration under MT (1.41 mg kg−1) compared to NT (1.10 mg kg−1). In particular, the results failed to establish if conservation tillage can increase the total phosphorus (TP) and potassium content (TK), where only in surface 0–10 cm an increase was observed. This research also suggested that the X-ray fluorescence analysis (XRF) of total micronutrient content (Zn, Cu, Fe, Mn) is minimal or unpredictable with no substantial differences between the tillage systems and straw return management practices. These findings suggest that conservation tillage in north-eastern Romania might be optimal to maintain soil quality status and sustain high yields.