bluuebunny/crossref_metadata_2025 huggingface dataset:
Output Power Smoothing and Voltage Regulation of a Fixed Speed Wind Generator in the Partial Load Region Using STATCOM and a Pitch Angle Controller
Authors: Naik Kanasottu , Gupta Chandra
Published: December 2017

The output power and terminal voltage of the fixed speed induction generator fluctuate in the partial load region where the wind speed is below the rated vale, resulting in fluctuations in the grid frequency and voltage. In this paper, a novel pitch angle control strategy has developed by introducing an exponential moving average (EMA) concept from which the controller reference power (signal) can be set for below-rated wind speeds. Therefore, the employed pitch angle controller together with static synchronous compensator (STATCOM), named the unified voltage and pitch angle controller (UVPC), addresses the objective of smoothing the output power and terminal voltage regulation of a wind generator, subjected to below-rated wind speed variations. Moreover, an interval type-2 fuzzy logic technique has incorporated in the pitch angle controller design, since it is more efficient in handling the uncertainties in membership functions and rules than its traditional fuzzy logic counterparts. Simulation results clearly show that the proposed UVPC effectively smoothens out the generator output power and also regulates the terminal voltage at its constant magnitude.
Comparative Analysis of P2P Architectures for Energy Trading and Sharing
Authors: Jogunola Olamide , Ikpehai Augustine , Anoh Kelvin , Adebisi Bamidele , Hammoudeh Mohammad , Gacanin Haris , Harris Georgina
Published: December 2017

Rising awareness and emergence of smart technologies have inspired new thinking in energy system management. Whilst integration of distributed energy resources in micro-grids (MGs) has become the technique of choice for consumers to generate their energy, it also provides a unique opportunity to explore energy trading and sharing amongst them. This paper investigates peer-to-peer (P2P) communication architectures for prosumers’ energy trading and sharing. The performances of common P2P protocols are evaluated under the stringent communication requirements of energy networks defined in IEEE 1547.3-2007. Simulation results show that the structured P2P protocol exhibits a reliability of 99.997% in peer discovery and message delivery whilst the unstructured P2P protocol yields 98%, both of which are consistent with the requirements of MG applications. These two architectures exhibit high scalability with a latency of 0.5 s at a relatively low bandwidth consumption, thus, showing promising potential in their adoption for prosumer to prosumer communication.
Spatial and Temporal Day-Ahead Total Daily Solar Irradiation Forecasting: Ensemble Forecasting Based on the Empirical Biasing
Authors: Baek Min-Kyu , Lee Duehee
Published: December 2017

Total daily solar irradiation for the next day is forecasted through an ensemble of multiple machine learning algorithms using forecasted weather scenarios from numerical weather prediction (NWP) models. The weather scenarios were predicted at grid points whose longitudes and latitudes are integers, but the total daily solar irradiation was measured at non-integer grid points. Therefore, six interpolation functions are used to interpolate weather scenarios at non-integer grid points, and their performances are compared. Furthermore, when the total daily solar irradiation for the next day is forecasted, many data trimming techniques, such as outlier detection, input data clustering, input data pre-processing, and output data post-processing techniques, are developed and compared. Finally, various combinations of these ensemble techniques, different NWP scenarios, and machine learning algorithms are compared. The best model is to combine multiple forecasting machines through weighted averaging and to use all NWP scenarios.
Forest Floor and Mineral Soil Respiration Rates in a Northern Minnesota Red Pine Chronosequence
Authors: Powers Matthew , Kolka Randall , Bradford John , Palik Brian , Jurgensen Martin
Published: December 2017

We measured total soil CO2 efflux (RS) and efflux from the forest floor layers (RFF) in red pine (Pinus resinosa Ait.) stands of different ages to examine relationships between stand age and belowground C cycling. Soil temperature and RS were often lower in a 31-year-old stand (Y31) than in 9-year-old (Y9), 61-year-old (Y61), or 123-year-old (Y123) stands. This pattern was most apparent during warm summer months, but there were no consistent differences in RFF among different-aged stands. RFF represented an average of 4–13% of total soil respiration, and forest floor removal increased moisture content in the mineral soil. We found no evidence of an age effect on the temperature sensitivity of RS, but respiration rates in Y61 and Y123 were less sensitive to low soil moisture than RS in Y9 and Y31. Our results suggest that soil respiration’s sensitivity to soil moisture may change more over the course of stand development than its sensitivity to soil temperature in red pine, and that management activities that alter landscape-scale age distributions in red pine forests could have significant impacts on rates of soil CO2 efflux from this forest type.
Fractional Diffusion Models for the Atmosphere of Mars
Authors: Jiménez Salvador , Usero David , Vázquez Luis , Velasco Maria
Published: December 2017

The dust aerosols floating in the atmosphere of Mars cause an attenuation of the solar radiation traversing the atmosphere that cannot be modeled through the use of classical diffusion processes. However, the definition of a type of fractional diffusion equation offers a more accurate model for this dynamic and the second order moment of this equation allows one to establish a connection between the fractional equation and the Ångstrom law that models the attenuation of the solar radiation. In this work we consider both one and three dimensional wavelength-fractional diffusion equations, and we obtain the analytical solutions and numerical methods using two different approaches of the fractional derivative.
Microbial Regulation of Glucose Metabolism and Insulin Resistance
Authors: Crommen Silke , Simon Marie-Christine
Published: December 2017

Type 2 diabetes is a combined disease, resulting from a hyperglycemia and peripheral and hepatic insulin resistance. Recent data suggest that the gut microbiota is involved in diabetes development, altering metabolic processes including glucose and fatty acid metabolism. Thus, type 2 diabetes patients show a microbial dysbiosis, with reduced butyrate-producing bacteria and elevated potential pathogens compared to metabolically healthy individuals. Furthermore, probiotics are a known tool to modulate the microbiota, having a therapeutic potential. Current literature will be discussed to elucidate the complex interaction of gut microbiota, intestinal permeability and inflammation leading to peripheral and hepatic insulin resistance. Therefore, this review aims to generate a deeper understanding of the underlying mechanism of potential microbial strains, which can be used as probiotics.
The Vulnerability of People to Damaging Hydrogeological Events in the Calabria Region (Southern Italy)
Authors: Petrucci Olga , Salvati Paola , Aceto Luigi , Bianchi Cinzia , Pasqua Angela , Rossi Mauro , Guzzetti Fausto
Published: December 2017

Background: Damaging Hydrogeological Events (DHEs) are severe weather periods during which floods, landslides, lightning, windstorms, hail or storm surges can harm people. Climate change is expected to increase the frequency/intensity of DHEs and, consequently, the potential harm to people. Method: We investigated the impacts of DHEs on people in Calabria (Italy) over 37 years (1980–2016). Data on 7288 people physically affected by DHEs were gathered from the systematic analysis of regional newspapers and collected in the database named PEOPLE. The damage was codified in three severity levels as follows: fatalities (people who were killed), injured (people who suffered physical harm) and involved (people who were present at the place where an accident occurred but survived and were not harmed). During the study period, we recorded 68 fatalities, 566 injured and 6654 people involved in the events. Results: Males were more frequently killed, injured and involved than females, and females who suffered fatalities were older than males who suffered fatalities, perhaps indicating that younger females tended to be more cautious than same-aged males, while older females showed an intrinsic greater vulnerability. Involved people were younger than injured people and fatalities, suggesting that younger people show greater promptness in reacting to dangerous situations. Floods caused the majority of the fatalities, injured and involved people, followed by landslides. Lightning was the most dangerous phenomenon, and it affected a relatively low number of people, killing 11.63% of them and causing injuries to 37.2%. Fatalities and injuries mainly occurred outdoors, largely along roads. In contrast, people indoors, essentially in public or private buildings, were more frequently involved without suffering harm. Being “dragged by water/mud” and “surrounded by water/mud”, respectively, represented the two extremes of dynamic dangerousness. The dragging effect of rapid-flowing water totally or partially obstructed the attempts of people to save their lives. In contrast, people surrounded by steady water/mud encountered difficulties but ultimately could survive. Conclusions: The study outcomes can be used in informational campaigns to increase risk awareness among both administrators and citizens and to improve community resilience, particularly in promoting self-protective behaviors and avoiding the underestimation of hazardous situations.
Impact of Interprofessional Relationships from Nurses’ Perspective on the Decision-Making Capacity of Patients in a Clinical Setting
Authors: Molina-Mula Jesús , Gallo-Estrada Julia , Perelló-Campaner Catalina
Published: December 2017

Interprofessional relationships may impact the decision making of patients in a clinical setting. The objective of this study was to analyse the decision-making capabilities of patients from nurses’ perspectives of interprofessional relationships using Foucauldian ethics. This qualitative study was based on poststructuralist Foucault references with in-depth interviews of nurses working in internal medicine and specialties in a general hospital. The patients constantly appeared in the definition of teamwork, but also as a passive element used by every professional to communicate with others. Nurses continue modelling a type of patient passivity, or what Foucault called passive subjectivity in relation to oneself, because the patient is guided and directed to take charge of a truth provided by professionals. Nurses must break the rigid design of sections or professional skills, and adopt a model of teamwork that meets the needs of the patient and increases their decision-making power. The quality of care will increase to the extent that professionals establish a relationship of equality with the patient, allowing the patient to make real decisions about their care. An egalitarian model of teamwork is beneficial to the patient, abandoning the idea of a team where the patient and family are constantly excluded from decisions about their care.
Simple Purification of Nicotiana benthamiana-Produced Recombinant Colicins: High-Yield Recovery of Purified Proteins with Minimum Alkaloid Content Supports the Suitability of the Host for Manufacturing Food Additives
Authors: Stephan Anett , Hahn-Löbmann Simone , Rosche Fred , Buchholz Mirko , Giritch Anatoli , Gleba Yuri
Published: December 2017

Colicins are natural non-antibiotic bacterial proteins with a narrow spectrum but an extremely high antibacterial activity. These proteins are promising food additives for the control of major pathogenic Shiga toxin-producing E. coli serovars in meats and produce. In the USA, colicins produced in edible plants such as spinach and leafy beets have already been accepted by the U. S. Food and Drug Administration (FDA) and U. S. Department of Agriculture (USDA) as food-processing antibacterials through the GRAS (generally recognized as safe) regulatory review process. Nicotiana benthamiana, a wild relative of tobacco, N. tabacum, has become the preferred production host plant for manufacturing recombinant proteins—including biopharmaceuticals, vaccines, and biomaterials—but the purification procedures that have been employed thus far are highly complex and costly. We describe a simple and inexpensive purification method based on specific acidic extraction followed by one chromatography step. The method provides for a high recovery yield of purified colicins, as well as a drastic reduction of nicotine to levels that could enable the final products to be used on food. The described purification method allows production of the colicin products at a commercially viable cost of goods and might be broadly applicable to other cost-sensitive proteins.
Fibrocytes: A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression
Authors: Goto Hisatsugu , Nishioka Yasuhiko
Published: December 2017

An adequate blood supply is essential for cancer cells to survive and grow; thus, the concept of inhibiting tumor angiogenesis has been applied to cancer therapy, and several drugs are already in clinical use. It has been shown that treatment with those anti-angiogenic drugs improved the response rate and prolonged the survival of patients with various types of cancer; however, it is also true that the effect was mostly limited. Currently, the disappointing clinical results are explained by the existence of intrinsic or acquired resistance to the therapy mediated by both tumor cells and stromal cells. This article reviews the mechanisms of resistance mediated by stromal cells such as endothelial cells, pericytes, fibroblasts and myeloid cells, with an emphasis on fibrocytes, which were recently identified as the cell type responsible for regulating acquired resistance to anti-angiogenic therapy. In addition, the other emerging role of fibrocytes as mediator-producing cells in tumor progression is discussed.
Identification of Two Novel Fibrinogen Bβ Chain Mutations in Two Slovak Families with Quantitative Fibrinogen Disorders
Authors: Simurda Tomas , Zolkova Jana , Snahnicanova Zuzana , Loderer Dusan , Skornova Ingrid , Sokol Juraj , Hudecek Jan , Stasko Jan , Lasabova Zora , Kubisz Peter
Published: December 2017

Congenital fibrinogen disorders are caused by mutations in one of the three fibrinogen genes that affect the synthesis, assembly, intracellular processing, stability or secretion of fibrinogen. Functional studies of mutant Bβ-chains revealed the importance of individual residues as well as three-dimensional structures for fibrinogen assembly and secretion. This study describes two novel homozygous fibrinogen Bβ chain mutations in two Slovak families with afibrinogenemia and hypofibrinogenemia. Peripheral blood samples were collected from all subjects with the aim of identifying the causative mutation. Coagulation-related tests and rotational thromboelastometry were performed. All exons and exon–intron boundaries of the fibrinogen genes (FGA, FGB and FGG) were amplified by PCR followed by direct sequencing. Sequence analysis of the three fibrinogen genes allowed us to identify two novel homozygous mutations in the FGB gene. A novel Bβ chain truncation (BβGln180Stop) was detected in a 28-year-old afibrinogenemic man with bleeding episodes including repeated haemorrhaging into muscles, joints, and soft tissues, and mucocutaneous bleeding and a novel Bβ missense mutation (BβTyr368His) was found in a 62-year-old hypofibrinogenemic man with recurrent deep and superficial venous thromboses of the lower extremities. The novel missense mutation was confirmed by molecular modelling. Both studying the molecular anomalies and the modelling of fibrinogenic mutants help us to understand the extremely complex machinery of fibrinogen biosynthesis and finally better assess its correlation with the patient’s clinical course.
An RTT-Aware Virtual Machine Placement Method
Authors: Quan Li , Wang Zhiliang , Ren Fuji
Published: December 2017

Virtualization is a key technology for mobile cloud computing (MCC) and the virtual machine (VM) is a core component of virtualization. VM provides a relatively independent running environment for different applications. Therefore, the VM placement problem focuses on how to place VMs on optimal physical machines, which ensures efficient use of resources and the quality of service, etc. Most previous work focuses on energy consumption, network traffic between VMs and so on and rarely consider the delay for end users’ requests. In contrast, the latency between requests and VMs is considered in this paper for the scenario of optimal VM placement in MCC. In order to minimize average RTT for all requests, the round-trip time (RTT) is first used as the metric for the latency of requests. Based on our proposed RTT metric, an RTT-Aware VM placement algorithm is then proposed to minimize the average RTT. Furthermore, the case in which one of the core switches does not work is considered. A VM rescheduling algorithm is proposed to keep the average RTT lower and reduce the fluctuation of the average RTT. Finally, in the simulation study, our algorithm shows its advantage over existing methods, including random placement, the traffic-aware VM placement algorithm and the remaining utilization-aware algorithm.
Vertebrate Left-Right Asymmetry: What Can Nodal Cascade Gene Expression Patterns Tell Us?
Authors: Schweickert Axel , Ott Tim , Kurz Sabrina , Tingler Melanie , Maerker Markus , Fuhl Franziska , Blum Martin
Published: December 2017

Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the Nodal signaling cascade in the lateral plate mesoderm of the neurula stage embryo, which results from a cilia-driven leftward flow of extracellular fluids at the left-right organizer. This scenario is widely accepted for laterality determination in wildtype specimens. Deviations from this norm come in different flavors. At the level of organ morphogenesis, laterality may be inverted (situs inversus) or non-concordant with respect to the main body axis (situs ambiguus or heterotaxia). At the level of Nodal cascade gene activation, expression may be inverted, bilaterally induced, or absent. In a given genetic situation, patterns may be randomized or predominantly lacking laterality (absence or bilateral activation). We propose that the distributions of patterns observed may be indicative of the underlying molecular defects, with randomizations being primarily caused by defects in the flow-generating ciliary set-up, and symmetrical patterns being the result of impaired flow sensing, on the left, the right, or both sides. This prediction, the reasoning of which is detailed in this review, pinpoints functions of genes whose role in laterality determination have remained obscure.
Progress for Journal of Functional Morphology and Kinesiology in 2017
Authors: Musumeci Giuseppe
Published: December 2017

n/a
Deriving Quantitative Crystallographic Information from the Wavelength-Resolved Neutron Transmission Analysis Performed in Imaging Mode
Authors: Sato Hirotaka
Published: December 2017

Current status of Bragg-edge/dip neutron transmission analysis/imaging methods is presented. The method can visualize real-space distributions of bulk crystallographic information in a crystalline material over a large area (~10 cm) with high spatial resolution (~100 μm). Furthermore, by using suitable spectrum analysis methods for wavelength-dependent neutron transmission data, quantitative visualization of the crystallographic information can be achieved. For example, crystallographic texture imaging, crystallite size imaging and crystalline phase imaging with texture/extinction corrections are carried out by the Rietveld-type (wide wavelength bandwidth) profile fitting analysis code, RITS (Rietveld Imaging of Transmission Spectra). By using the single Bragg-edge analysis mode of RITS, evaluations of crystal lattice plane spacing (d-spacing) relating to macro-strain and d-spacing distribution’s FWHM (full width at half maximum) relating to micro-strain can be achieved. Macro-strain tomography is performed by a new conceptual CT (computed tomography) image reconstruction algorithm, the tensor CT method. Crystalline grains and their orientations are visualized by a fast determination method of grain orientation for Bragg-dip neutron transmission spectrum. In this paper, these imaging examples with the spectrum analysis methods and the reliabilities evaluated by optical/electron microscope and X-ray/neutron diffraction, are presented. In addition, the status at compact accelerator driven pulsed neutron sources is also presented.
An Ecological Visual Exploration Tool to Support the Analysis of Visual Processing Pathways in Children with Autism Spectrum Disorders
Authors: Cazzato Dario , Leo Marco , Distante Cosimo , Crifaci Giulia , Bernava Giuseppe , Ruta Liliana , Pioggia Giovanni , Castro Silvia
Published: December 2017

Recent improvements in the field of assistive technologies have led to innovative solutions aiming at increasing the capabilities of people with disability, helping them in daily activities with applications that span from cognitive impairments to developmental disabilities. In particular, in the case of Autism Spectrum Disorder (ASD), the need to obtain active feedback in order to extract subsequently meaningful data becomes of fundamental importance. In this work, a study about the possibility of understanding the visual exploration in children with ASD is presented. In order to obtain an automatic evaluation, an algorithm for free (i.e., without constraints, nor using additional hardware, infrared (IR) light sources or other intrusive methods) gaze estimation is employed. Furthermore, no initial calibration is required. It allows the user to freely rotate the head in the field of view of the sensor, and it is insensitive to the presence of eyeglasses, hats or particular hairstyles. These relaxations of the constraints make this technique particularly suitable to be used in the critical context of autism, where the child is certainly not inclined to employ invasive devices, nor to collaborate during calibration procedures.The evaluation of children’s gaze trajectories through the proposed solution is presented for the purpose of an Early Start Denver Model (ESDM) program built on the child’s spontaneous interests and game choice delivered in a natural setting.
Proton Conduction in Grain-Boundary-Free Oxygen-Deficient BaFeO2.5+δ Thin Films
Authors: Benes Alexander , Molinari Alan , Witte Ralf , Kruk Robert , Brötz Joachim , Chellali Reda , Hahn Horst , Clemens Oliver
Published: December 2017

Reduction of the operating temperature to an intermediate temperature range between 350 °C and 600 °C is a necessity for Solid Oxide Fuel/Electrolysis Cells (SOFC/SOECs). In this respect the application of proton-conducting oxides has become a broad area of research. Materials that can conduct protons and electrons at the same time, to be used as electrode catalysts on the air electrode, are especially rare. In this article we report on the proton conduction in expitaxially grown BaFeO2.5+δ (BFO) thin films deposited by pulsed laser deposition on Nb:SrTiO3 substrates. By using Electrochemical Impedance Spectroscopy (EIS) measurements under different wet and dry atmospheres, the bulk proton conductivity of BFO (between 200 °C and 300 °C) could be estimated for the first time (3.6 × 10−6 S cm−1 at 300 °C). The influence of oxidizing measurement atmosphere and hydration revealed a strong dependence of the conductivity, most notably at temperatures above 300 °C, which is in good agreement with the hydration behavior of BaFeO2.5 reported previously.
Strain Rate Effect on Tensile Behavior for a High Specific Strength Steel: From Quasi-Static to Intermediate Strain Rates
Authors: Wang Wei , Ma Yan , Yang Muxin , Jiang Ping , Yuan Fuping , Wu Xiaolei
Published: December 2017

The strain rate effect on the tensile behaviors of a high specific strength steel (HSSS) with dual-phase microstructure has been investigated. The yield strength, the ultimate strength and the tensile toughness were all observed to increase with increasing strain rates at the range of 0.0006 to 56/s, rendering this HSSS as an excellent candidate for an energy absorber in the automobile industry, since vehicle crushing often happens at intermediate strain rates. Back stress hardening has been found to play an important role for this HSSS due to load transfer and strain partitioning between two phases, and a higher strain rate could cause even higher strain partitioning in the softer austenite grains, delaying the deformation instability. Deformation twins are observed in the austenite grains at all strain rates to facilitate the uniform tensile deformation. The B2 phase (FeAl intermetallic compound) is less deformable at higher strain rates, resulting in easier brittle fracture in B2 particles, smaller dimple size and a higher density of phase interfaces in final fracture surfaces. Thus, more energy need be consumed during the final fracture for the experiments conducted at higher strain rates, resulting in better tensile toughness.
Activation Profile Analysis of CruCA4, an α-Carbonic Anhydrase Involved in Skeleton Formation of the Mediterranean Red Coral, Corallium rubrum
Authors: Del Prete Sonia , Vullo Daniela , Zoccola Didier , Tambutté Sylvie , Supuran Claudiu , Capasso Clemente
Published: December 2017

CruCA4, a coral α-carbonic anhydrase (CA, EC 4.2.1.1) involved in the biomineralization process of the Mediterranean red coral, Corallium rubrum, was investigated for its activation with a panel of amino acids and amines. Most compounds showed considerable activating properties, with a rather well defined structure–activity relationship. The most effective CruCA4 activators were d-His, 4-H2N-l-Phe, Histamine, Dopamine, Serotonin, 1-(2-Aminoethyl)-piperazine, and l-Adrenaline, with activation constants in the range of 8–98 nM. Other amines and amino acids, such as d-DOPA, l-Tyr, 2-Pyridyl-methylamine, 2-(2-Aminoethyl) pyridine and 4-(2-Aminoethyl)-morpholine, were submicromolar CruCA4 activators, with KA ranging between 0.15 and 0.93 µM. Since it has been shown that CA activators may facilitate the initial phases of in-bone mineralization, our study may be relevant for finding modulators of enzyme activity, which can enhance the formation of the red coral skeleton.
Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review
Authors: Avila-Vazquez Maria , Altamirano-Bustamante Nelly , Altamirano-Bustamante Myriam
Published: December 2017

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones.
Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD)
Authors: Saeed Ali , Dullaart Robin , Schreuder Tim , Blokzijl Hans , Faber Klaas
Published: December 2017

Vitamin A is required for important physiological processes, including embryogenesis, vision, cell proliferation and differentiation, immune regulation, and glucose and lipid metabolism. Many of vitamin A’s functions are executed through retinoic acids that activate transcriptional networks controlled by retinoic acid receptors (RARs) and retinoid X receptors (RXRs).The liver plays a central role in vitamin A metabolism: (1) it produces bile supporting efficient intestinal absorption of fat-soluble nutrients like vitamin A; (2) it produces retinol binding protein 4 (RBP4) that distributes vitamin A, as retinol, to peripheral tissues; and (3) it harbors the largest body supply of vitamin A, mostly as retinyl esters, in hepatic stellate cells (HSCs). In times of inadequate dietary intake, the liver maintains stable circulating retinol levels of approximately 2 μmol/L, sufficient to provide the body with this vitamin for months. Liver diseases, in particular those leading to fibrosis and cirrhosis, are associated with impaired vitamin A homeostasis and may lead to vitamin A deficiency. Liver injury triggers HSCs to transdifferentiate to myofibroblasts that produce excessive amounts of extracellular matrix, leading to fibrosis. HSCs lose the retinyl ester stores in this process, ultimately leading to vitamin A deficiency. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is a spectrum of conditions ranging from benign hepatic steatosis to non-alcoholic steatohepatitis (NASH); it may progress to cirrhosis and liver cancer. NASH is projected to be the main cause of liver failure in the near future. Retinoic acids are key regulators of glucose and lipid metabolism in the liver and adipose tissue, but it is unknown whether impaired vitamin A homeostasis contributes to or suppresses the development of NAFLD. A genetic variant of patatin-like phospholipase domain-containing 3 (PNPLA3-I148M) is the most prominent heritable factor associated with NAFLD. Interestingly, PNPLA3 harbors retinyl ester hydrolase activity and PNPLA3-I148M is associated with low serum retinol level, but enhanced retinyl esters in the liver of NAFLD patients. Low circulating retinol in NAFLD may therefore not reflect true “vitamin A deficiency”, but rather disturbed vitamin A metabolism. Here, we summarize current knowledge about vitamin A metabolism in NAFLD and its putative role in the progression of liver disease, as well as the therapeutic potential of vitamin A metabolites.
Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma
Authors: Sun Lili , Ding Feifei , You Guangjiao , Liu Han , Wang Meng , Ren Xiaoliang , Deng Yanru
Published: December 2017

JinQi Jiangtang (JQJT) tablets, a Chinese patent medicine approved by the State Food and Drug Administration, are composed of Coptidis Rhizoma, Astragali Radix, and Lonicerae Japonicae Flos, and have a significant effect on diabetes. Coptidis Rhizoma is monarch drug in the prescription. The aim of the present study was to investigate and compare the pharmacokinetics of multiple ingredients from JQJT tablets and Coptidis Rhizoma extract (CRE) following oral administration in rats. Five alkaloids: coptisine chloride, epiberberine chloride, berberine chloride, jatrorrhizine chloride, and palmatine chloride, were simultaneously determined in rat plasma using established and validated ultra-high performance liquid chromatography mass spectrometry (UPLC-MS/MS). Significant pharmacokinetic differences were observed for the five alkaloids after a single administration of CRE and JQJT tablets. Compared with CRE, the Cmax values of palmatine chloride and jatrorrhizine chloride were decreased significantly, the AUC0–t values of four alkaloids (all except jatrorrhizine chloride) were notably decreased, and the mean residence times of all five alkaloids were significantly decreased after administration of JQJT tablets. The results indicated that the absorption characteristics of the five alkaloids from Coptidis Rhizoma would be influenced by the compatibility of Astragali Radix or Lonicerae Japonicae Flos from JQJT tablets, such that absorption was inhibited and elimination was accelerated. In conclusion, the developed strategy was suitable for the comparison of five alkaloids from JinQi Jiangtang tablets and its monarch drug, which could be valuable for compatibility studies of traditional Chinese medicines.
Review of Progress in Shape Memory Epoxies and Their Composites
Authors: Karger-Kocsis József , Kéki Sándor
Published: December 2017

Shape memory polymer (SMP) is capable of memorizing one or more temporary shapes and recovering successively to the permanent shape upon various external stimuli. Beside of the above mentioned one-way variants, also two-way shape memory polymers (SMPs) and shape memory (SM) systems exist which feature a reversible shape change on the basis of “on-off switching” of the external stimulus. The preparation, properties and modelling of shape memory epoxy resins (SMEP), SMEP foams and composites have been surveyed in this exhaustive review article. The underlying mechanisms and characteristics of SM were introduced. Emphasis was put to show new strategies on how to tailor the network architecture and morphology of EPs to improve their SM performance. To produce SMEPs novel preparation techniques, such as electrospinning, ink printing, solid-state foaming, were tried. The potential of SMEPs and related systems as multifunctional materials has been underlined. Added functionality may include, among others, self-healing, sensing, actuation, porosity control, recycling. Recent developments in the modelling of SMEPs were also highlighted. Based on the recent developments some open topics were deduced which are merit of investigations in future works.
Using Markov Chains and Multi-Objective Optimization for Energy-Efficient Context Recognition
Authors: Janko Vito , Luštrek Mitja
Published: December 2017

The recognition of the user’s context with wearable sensing systems is a common problem in ubiquitous computing. However, the typically small battery of such systems often makes continuous recognition impractical. The strain on the battery can be reduced if the sensor setting is adapted to each context. We propose a method that efficiently finds near-optimal sensor settings for each context. It uses Markov chains to simulate the behavior of the system in different configurations and the multi-objective genetic algorithm to find a set of good non-dominated configurations. The method was evaluated on three real-life datasets and found good trade-offs between the system’s energy expenditure and the system’s accuracy. One of the solutions, for example, consumed five-times less energy than the default one, while sacrificing only two percentage points of accuracy.
Fabrication of Glass Microchannel via Glass Imprinting using a Vitreous Carbon Stamp for Flow Focusing Droplet Generator
Authors: Jang Hyungjun , Refatul Haq Muhammad , Kim Youngkyu , Kim Jun , Oh Pyoung-hwa , Ju Jonghyun , Kim Seok-Min , Lim Jiseok
Published: December 2017

This study reports a cost-effective method of replicating glass microfluidic chips using a vitreous carbon (VC) stamp. A glass replica with the required microfluidic microstructures was synthesized without etching. The replication method uses a VC stamp fabricated by combining thermal replication using a furan-based, thermally-curable polymer with carbonization. To test the feasibility of this method, a flow focusing droplet generator with flow-focusing and channel widths of 50 µm and 100 µm, respectively, was successfully fabricated in a soda-lime glass substrate. Deviation between the geometries of the initial shape and the vitreous carbon mold occurred because of shrinkage during the carbonization process, however this effect could be predicted and compensated for. Finally, the monodispersity of the droplets generated by the fabricated microfluidic device was evaluated.
A Review of Light Shelf Designs for Daylit Environments
Authors: Kontadakis Antonis , Tsangrassoulis Aris , Doulos Lambros , Zerefos Stelios
Published: December 2017

Light shelves have been discussed in numerous studies as suitable solutions for controlling daylight in side-lit spaces. It is a system that can be easily modified, offering a range of design solutions. It can be easily mounted on the exterior and/or the interior of a vertical opening, it can come in various shapes from static flat forms to curved reflective surfaces, or it can even be actively controlled. A light shelf can offer shading and at the same time can redirect a significant part of the incoming light flux towards the ceiling improving daylight uniformity. Due to the aforesaid functions, light shelves are among the most popular system design solutions when it comes to daylight exploitation. The purpose of this paper is twofold. Firstly, to present the main research findings in relation to light shelves as daylighting systems and secondly to analyze the results, trying to establish a common basis for some efficient and practical design rules. The present paper is a review of the research realized in the last three decades concerning these systems together with their associated implications in a building’s daylight performance as well as in its energy balance in a few cases. In addition, the critical review of their design principles is included, which makes the presented information useful for design teams trying to select the optimal available system for any specific project.
Modeling and Simulation of the Future Impacts of Urban Land Use Change on the Natural Environment by SLEUTH and Cluster Analysis
Authors: Kuo Hsing-Fu , Tsou Ko-Wan
Published: December 2017

Changing land use and urban expansion are key drivers of global environmental change, which are inevitable consequences of economic and social development for many cities. Most land use changes have a negative impact on the natural environment, especially due to their effects on surface temperature, runoff and habitat diversity. Due to the limitation of local government funding and expenditure, it is a challenge for developing countries to create strategies for urban sustainability. This study provided a systematic assessment method for simulating and analyzing the future impacts and spatial patterns of urban growth via cellular automata and cluster analysis. We used Tainan as a study area and compared the impact of future urban spatial development during two periods: 1993–2008 and 2008–2030. The results indicate that the impact of this development on the natural environment can be divided into six clusters. With an increased distance from the city center, there were increased changes in surface temperature and a decreased amount of runoff. These results indicate the occurrence of urban expansion, with habitat diversity being greater in areas governed by policies or ordinances.
International Tourists’ Perceived Sustainability of Jeju Island, South Korea
Authors: Kim Min-Seong , Thapa Brijesh , Kim Hany
Published: December 2017

This study investigated the causal relationships between international tourists’ perceived sustainability of Jeju Island, South Korea and environmentally responsible behavior, revisit intention, and positive word-of-mouth communication. Perceived sustainability was employed as a multidimensional construct comprised of economic, cultural, and environmental aspects. Data were collected from international tourists that visited Jeju Island. The results indicated that environmentally responsible behavior was influenced positively by cultural sustainability, and negatively by environmental sustainability. Revisit intention and positive word-of-mouth communication were significantly affected by the three dimensions of sustainability. Based on the findings, associated implications were suggested for sustainable destination management of Jeju Island.
Exploring the Patterns and Mechanisms of Reclaimed Arable Land Utilization under the Requisition-Compensation Balance Policy in Wenzhou, China
Authors: Lin Lin , Jia Hongzhen , Pan Yi , Qiu Lefeng , Gan Muye , Lu Shenggao , Deng Jinsong , Yu Zhoulu , Wang Ke
Published: December 2017

Arable land in China is undergoing significant changes, with massive losses of arable land due to rapid urbanization and the reclamation of arable land from other lands to compensate for these losses. Many studies have analyzed arable land loss, but less attention has been paid to land reclamation, and the utilization of reclaimed land remains unclear. The goal of our study was to characterize the patterns and efficiency of the utilization of reclaimed land and to identify the factors influencing the land utilization process in Wenzhou using remote sensing, geographic information systems and logistic regression. Our results showed that only 37% of the total reclaimed land area was under cultivation, and other lands were still bare or had been covered by trees and grasses. The likelihood that reclaimed land was used for cultivation was highly correlated with the land use type of its neighboring or adjacent parcels. Reclaimed land utilization was also limited at high elevations in lands with poor soil fertility and in lands at a great distance from rural residential areas. In addition, parcels located in the ecological protection zone were less likely to be cultivated. Therefore, we suggest that the important determinants should be considered when identifying the most suitable land reclamation areas.
Designing a Climate-Resilient Environmental Curriculum—A Transdisciplinary Challenge
Authors: Yu Cheng-Yu , Chiang Yi-Chang
Published: December 2017

Building resilience is a promising transdisciplinary area that contributes to addressing the impacts of climate change. This paper focused on the design of climate-resilient environmental curriculums to enhance environmental quality. Transdisciplinary approaches have been recognized as being well-placed to assist responses to climate change, which is a complex phenomenon and problem. Semi-structured interviews were conducted to explore how climate-resilient environmental education can be integrated into the design, implementation, and practice transdisciplinary manner into curriculums. Transdisciplinary curriculum design is an important factor determining the quality of modules, especially in the field of environmental design, due to its real-life setting characteristics. As students are trained with new projects, and under different socioeconomic and environmental conditions, curriculum design requires modification. Moreover, promoting transdisciplinary studies is a new trend that influences curriculum design. Compared to the interdisciplinary approach, the transdisciplinary approach is concerned with issues and subjects that exist between disciplines, across different disciplines, and beyond all the disciplines, leading to an immense space of new knowledge. This approach leads to integrated research that involves non-academic participants. We concluded that the transdisciplinary approach is beneficial for students in two ways: better performance in practical modules, and addresses the real interests of the students. Feedback from students about the curriculum design suggested that, to consider the individual student’s personal circumstances, multiple training methods should be used. The transdisciplinary approach to climate-resilient environmental curriculum design using a participative process amongst stakeholders is crucial; however, in this study, different opinions amongst interviewed tutors may obstruct the realization of the students’ wishes.
Helicene-Based Chiral Auxiliaries and Chirogenesis
Authors: Hasan Mohammed , Borovkov Victor
Published: December 2017

Helicenes are unique helical chromophores possessing advanced and well-controlled spectral and chemical properties owing to their diverse functionalization and defined structures. Specific modification of these molecules by introducing aromatic rings of differing nature and different functional groups results in special chiroptical properties, making them effective chiral auxiliaries and supramolecular chirogenic hosts. This review aims to highlight these distinct structural features of helicenes; the different synthetic and supramolecular approaches responsible for their efficient chirality control; and their employment in the chirogenic systems, which are still not fully explored. It further covers the limitation, scope, and future prospects of helicene chromophores in chiral chemistry.
Identification of Apple Leaf Diseases Based on Deep Convolutional Neural Networks
Authors: Liu Bin , Zhang Yun , He DongJian , Li Yuxiang
Published: December 2017

Mosaic, Rust, Brown spot, and Alternaria leaf spot are the four common types of apple leaf diseases. Early diagnosis and accurate identification of apple leaf diseases can control the spread of infection and ensure the healthy development of the apple industry. The existing research uses complex image preprocessing and cannot guarantee high recognition rates for apple leaf diseases. This paper proposes an accurate identifying approach for apple leaf diseases based on deep convolutional neural networks. It includes generating sufficient pathological images and designing a novel architecture of a deep convolutional neural network based on AlexNet to detect apple leaf diseases. Using a dataset of 13,689 images of diseased apple leaves, the proposed deep convolutional neural network model is trained to identify the four common apple leaf diseases. Under the hold-out test set, the experimental results show that the proposed disease identification approach based on the convolutional neural network achieves an overall accuracy of 97.62%, the model parameters are reduced by 51,206,928 compared with those in the standard AlexNet model, and the accuracy of the proposed model with generated pathological images obtains an improvement of 10.83%. This research indicates that the proposed deep learning model provides a better solution in disease control for apple leaf diseases with high accuracy and a faster convergence rate, and that the image generation technique proposed in this paper can enhance the robustness of the convolutional neural network model.
Anti-Helicobacter pylori Properties of the Ant-Venom Peptide Bicarinalin
Authors: Guzman Jesus , Téné Nathan , Touchard Axel , Castillo Denis , Belkhelfa Haouaria , Haddioui-Hbabi Laila , Treilhou Michel , Sauvain Michel
Published: December 2017

The venom peptide bicarinalin, previously isolated from the ant Tetramorium bicarinatum, is an antimicrobial agent with a broad spectrum of activity. In this study, we investigate the potential of bicarinalin as a novel agent against Helicobacter pylori, which causes several gastric diseases. First, the effects of synthetic bicarinalin have been tested against Helicobacter pylori: one ATCC strain, and forty-four isolated from stomach ulcer biopsies of Peruvian patients. Then the cytoxicity of bicarinalin on human gastric cells and murine peritoneal macrophages was measured using XTT and MTT assays, respectively. Finally, the preventive effect of bicarinalin was evaluated by scanning electron microscopy using an adherence assay of H. pylori on human gastric cells treated with bicarinalin. This peptide has a potent antibacterial activity at the same magnitude as four antibiotics currently used in therapies against H. pylori. Bicarinalin also inhibited adherence of H. pylori to gastric cells with an IC50 of 0.12 μg·mL−1 and had low toxicity for human cells. Scanning electron microscopy confirmed that bicarinalin can significantly decrease the density of H. pylori on gastric cells. We conclude that Bicarinalin is a promising compound for the development of a novel and effective anti-H. pylori agent for both curative and preventive use.