bluuebunny/crossref_metadata_2025 huggingface dataset:
Human NGF “Painless” Ocular Delivery for Retinitis Pigmentosa: An In Vivo Study
Authors: Napoli Debora , Orsini Noemi , Salamone Giulia , Calvello Maria Antonietta , Capsoni Simona , Cattaneo Antonino , Strettoi Enrica
Published: September 2024

Retinitis pigmentosa (RP) is a family of genetically heterogeneous diseases still without a cure. Despite the causative genetic mutation typically not expressed in cone photoreceptors, these cells inevitably degenerate following the primary death of rods, causing blindness. The reasons for the “bystander” degeneration of cones are presently unknown but decrement of survival factors, oxidative stress, and inflammation all play a role. Targeting these generalized biological processes represents a strategy to develop mutation-agnostic therapies for saving vision in large populations of RP individuals. A classical method to support neuronal survival is by employing neurotrophic factors, such as NGF. This study uses painless human NGF (hNGFp), a TrkA receptor-biased variant of the native molecule with lower affinity for nociceptors and limited activity as a pain inducer; the molecule has identical neurotrophic power of the native form but a reduced affinity for the p75NTR receptors, known to trigger apoptosis. hNGFp has a recognized activity on brain microglial cells, which are induced to a phenotype switch from a highly activated to a more homeostatic configuration. hNGFp was administered to RP-like mice in vivo with the aim of decreasing retinal inflammation and also providing retinal neuroprotection. However, the ability of this treatment to counteract the bystander degeneration of cones remained limited.
O czym milczy Archiwum Filomatów?
Authors:   Wydział Polonistyki, Uniwersytet Warszawski, Makaruk Maria
Published: September 2024

The author of the sketch presents two ways in which the notion of the Philomaths’ Archive can be understood, advocating a broader perspective that incorporates the developments of the “archival turn” in literary studies. She reconstructs the largely absent from Polish research biographies of Szymon Dowkont, Kajetan Niezabitowski and Szymon Staniewicz – precursors of the Lithuanian national revival, who studied at Vilnius University during the time of the Philomath and Philaret Societies. The author draws attention to the points where the biographies of the sketch protagonists and the Philomaths and Philarets may have intersected. She further points to the absence of a shared perspective in Polish and Lithuanian research and postulates bridging this gap, indicating the newly opened areas of research.
El deseo y los afectos: Spinoza a través de la lectura de Lacan
Authors: Jabase Leila
Published: September 2024

El presente artículo se ocupa de algunos elementos comunes que consideramos pueden encontrarse entre Spinoza y Lacan. Sin que ello implique soslayar las diferencias, nos referimos a algunos conceptos e inquietudes compartidas como son la revalorización de los afectos y pulsiones, la centralidad de los conceptos de cuerpo y deseo, la importancia de las huellas o vestigium en la constitución de los sujetos o ‘modos’, así como la concepción de una curación o liberación por medio de la potencia del saber. Nuestra labor consiste en tomar ciertas referencias o sentencias lacanianas que remiten directa o indirectamente a Spinoza y contraponer cómo Spinoza mismo las entiende en el marco de su sistema filosófico. Al mismo tiempo, a través de estas instancias buscaremos aportar elementos sobre la manera en que Lacan logra vincular la filosofía de Spinoza a su propio desarrollo teórico.
Anacronismo e historia. Una discusión en torno a la utilización del concepto de ‘lo político’
Authors: Barrionuevo Sergio Javier
Published: September 2024

El anacronismo, que implica la aplicación de conceptos o ideas de una época a otra, se suele considerar uno de los errores más graves en la narrativa histórica. La corriente historiográfica conocida como historia conceptual es una de las que reconoce y busca evitar este problema. Dentro de este contexto, Elias J. Palti ha defendido la idea de que el concepto de “lo político” se originó en la Era moderna. Según su argumento, utilizar este concepto para analizar sociedades anteriores podría llevar a malentendidos y distorsiones en la comprensión de su funcionamiento. Sin embargo, el objetivo de este trabajo es desafiar esta perspectiva y proponer la posibilidad de aplicar el concepto de “lo político” al estudio de sociedades premodernas. En lugar de rechazar automáticamente la aplicación de conceptos modernos, se busca explorar cómo pueden enriquecer nuestro conocimiento de la historia, incluso en contextos temporales diferentes al suyo de origen.
ART IN HISTORY: RESISTING SOCIAL INVISIBILITY
Authors: Bal Mieke
Published: September 2024

I seek to understand the skill of looking, the solid basis of art history, but specifically the “how to” of it that we take too easily for granted. That looking leads to seeing is not obvious. In this article I develop a theoretical metaphor that is social, ethical, and visual, and can help art history in its mission. This is how it came to me. Once, on the street, I heard a man, of obviously foreign background, murmur to himself: “they don’t even look at me”. That was the moment when the seed of the short film embedded in this article was sown, and the theoretical metaphor of visibilisation came up. The consequence of this not looking and not talking in some sort of engagement with him, is that he radically does not belong, is not part of, the group within which he exists physically – the crowd.
Racismo indígena en la escuela. Hacia un estado del arte
Authors: Sulca Elisa Martina de los Ángeles
Published: September 2024

Racism is a social and historical matrix made up of discriminatory practices, prejudiced attitudes, stereotyped representations, feelings of contempt, and forms of physical and symbolic violence. It is a system of hierarchies built because of social origin, skin color, descent or national origin, indigenous status, and religion. There are as many racisms as there are groups that need to justify their superiority and the exercise of relations of domination. One of the most serious consequences is inequality in access to fundamental rights such as education, health, employment, and housing. This article proposes to elaborate a state of the art on the manifestations of indigenous racism in the school environment. Academic productions of theoretical and empirical base framed in a socio-educational perspective developed by national and international organizations, by research teams from universities or specialized institutes and postgraduate theses are recovered and systematized. Systematized studies focus on the various expressions of indigenous racism in schools, particularly in institutional practices, in daily interactions, and in the curriculum. They note the effects of this phenomenon on feelings of shame and fear, on prolonged and interrupted educational trajectories, and on processes of exclusion and self-exclusion.
Lengua de Signos Española (LSE) y léxico especializado de las peluquerías. Análisis y propuestas de mejora
Authors: Valdés González Aránzazu , Martín Antón Javier
Published: September 2024

This work aims to share the process developed to determine the lexical availability in lexicographic materials of Spanish Sign Language (LSE) for 47 concepts within a specialized field of knowledge: hairdressing. Sign languages, such as LSE in our case, encounter the ongoing necessity, akin to oral languages, of devising novel lexical entities for those concepts devoid of them. To accomplish this, languages have lexical creation mechanisms. Once the search, analysis and discussion process designed for this study was completed, it is determined that LSE dictionaries do not include a Sign for 71.1 % of the concepts examined. Nonetheless, as a result of this study, we present an audiovisual material that captures, in LSE, the 47 Spanish words examined. This outcome owes its realization to the collective endeavor of hairdressing professionals, Deaf individuals, LSE interpreters, and hearing individuals endowed with profound understanding of LSE and the procedures entailed in creating novel Signs. Consequently, it is demonstrated that LSE is a living and rich language capable of addressing any communication needs, regardless of the specialization of the field.
La Comisión del Idioma Oficial (1993-1994): una iniciativa de política lingüística en la postdictadura chilena
Authors: Rojas Darío
Published: September 2024

This paper analyzes the initiative to create a Committee for the Official Language (CIO) in Chile between 1993 and 1994. The analysis is based on documents that remain unpublished and almost completely unknown, despite their relevance for the historiography of language policy in post-dictatorial Chile. Taking a glottopolitical approach, we understand the creation of the CIO as an intervention in the public space of language that aims to influence the constitution of the regime of linguistic normativity of the period. In this sense, we will analyze the way in which the CIO proposes a series of options loaded with glottopolitical meanings, such as the selection of Spanish as the official language, and the preference for a certain way of calling the language, among others. These respond to the ideological matrix of Hispanism, from which the ideologemes mobilised in the CIO’s actions and decisions originate, and in relation to which they make sense from a long-term historical perspective.
Gobierno Vasco. Departamento de Educación, Universidades e Investigación (2005). Manual de Lenguaje de Signos. Educación Primaria. Primer Ciclo
Authors: Malarin Flavia
Published: September 2024

En los últimos años, se ha incrementado significativamente el interés por el estudio de la lengua de señas, especialmente en el ámbito educativo. La inclusión de esta lengua en el currículo escolar no solo es fundamental para la integración de niños y niñas sordos, sino que también enriquece a toda la comunidad educativa. Resulta sorprendente imaginar un aula donde todos los estudiantes, independientemente de su capacidad auditiva, puedan comunicarse de manera fluida y comprenderse unos a otros. Estos estudios permiten seleccionar, clasificar y registrar las diversas señas y sus significados, lo cual es crucial para facilitar la comunicación y la interacción entre estudiantes sordos y oyentes. Marzo et al. (2022) destacan que la lengua de señas, con su carácter viso-gestual-espacial, representa un sistema lingüístico que ha ganado reconocimiento social y se está integrando cada vez más en la educación de las personas sordas. Este avance subraya la percepción de la lengua de señas como un recurso y un derecho fundamental para la educación, y la reconoce como un símbolo y patrimonio cultural de la comunidad sorda. Este esfuerzo educativo es esencial para fomentar una comprensión más profunda del mundo y eliminar las barreras comunicativas y sociales que, a menudo, aíslan a las personas sordas (p. 7).
Vyacheslav Fedorovych Klepikov (to his 75th birthday)
Authors: Azarenkov M.O. , Babich A.V. , Bazaleev M.I. , Bryukhovetsky V.V. , Bilous V.A. , Bulavin L.A. , Garkusha I.Ye. , Girka I.O. , Denisov V.Y. , Zabulonov Yu.L. , Karnauhov I.M. , Kasatkin Yu.O. , Kyryllin I.V. , Kovalenko G.D. , Konovalenko O.O. , Korda V.Yu. , Kocheshev I.O. , Kuznietsov P.E. , Neklyudov I.M. , Lytvynenko V.V. , Slisenko V.I. , Slyusarenko Yu.V. , Storizhko V.Yu. , Tolstolutska G.D. , Onishchenko I.M. , Popov O.O. , Ostapchuk P.M. , Prokhorenko E.M.
Published: September 2024

07.13.2024 75 years have passed since the birthday of Vyacheslav Fedorovych Klepikov, a well-known theoretical physicist, Doctor of physical and mathematical sciences, Professor, Correspondent member of the National Academy of Sciences of Ukraine.
Effectiveness of Black Cumin (Nigella sativa L.) Extract on Increasing Stamina in Male Mice (Mus musculus)
Authors: Melita Raina Aulia , Maretha Delima Engga , Nurokhman Amin
Published: September 2024

AbstractResearch using ethanol extract from black cumin seeds aims to find out whether black cumin seed extract (Nigella sativa) can be effective in increasing the stamina of male mice. The research design used was a completely randomized design (RAL). The samples used were 24 male mice consisting of four treatments and six repetitions. The dosing treatment consisted of a normal control group (P0), 30 mg/kg weight (P1), 60 mg/kg weight (P2), and 120 mg/kg weight (P3). The swimming test method was used to determine the effect of increasing stamina on mice. Data on the swimming duration of mice were analyzed using the ANOVA test then continued using the Post Hoc Test, namely LSD. The average stamina of mice based on swimming duration was the highest, namely at a dose of 120 mg/kgW (P3). Administration of black cumin seed extract (Nigella sativa) at doses of 30 mg/kgBW, 60 mg/kgW, and 120 mg/kgW for 14 days provided effectiveness in increasing stamina in male white mice (Mus musculus) as indicated by an increase in the swimming duration of the mice in each treatment.AbstrakPenelitian menggunakan ekstrak etanol biji jinten hitam bertujuan untuk mengetahui apakah ekstrak biji jinten hitam (Nigella sativa) dapat berpengaruh terhadap peningkatan stamina mencit jantan. Rancangan penelitian yang digunakan ialah rancangan acak lengkap (RAL). Sampel yang digunakan sebanyak 24 ekor mencit jantan yang terdiri dari empat perlakuan dan enam pengulangan. Perlakuan pemberian dosis terdiri atas kelompok kontrol normal (P0), 30 mg/kgBB (P1), 60 mg/kgBB (P2), dan 120 mg/kgBB (P3). Metode swimming test digunakan untuk mengetahui efek peningkatan stamina terhadap mencit. Data durasi renang mencit dianalisis menggunakan uji ANOVA kemudian dilanjutkan menggunakan uji Post Hoc Test yaitu LSD. Rata-rata stamina mencit berdasarkan durasi renang yang paling tinggi yaitu pada dosis 120 mg/kgBB (P3). Pemberian ekstrak biji jinten hitam (Nigella sativa) pada dosis 30 mg/kgBB, 60 mg/kgBB, dan 120 mg/kgBB selama 14 hari dapat berpengaruh dalam peningkatan stamina pada mencit putih jantan (Mus musculus) ditandai meningkatnya durasi renang mencit dimasing-masing perlakuan.
The Effect of Moringa Leaf Extract Administration on Sperm Morphology and Blood Glucose Reduction in Alloxan-Induced Sprague Dawley Rats
Authors: Wahab Dinda Nuraini Hanifah , Hasanah Uswatun , Harfiani Erna , Thadeus Maria Selvester
Published: September 2024

AbstractIncreased blood sugar levels can be triggered by increased intake or insulin resistance, leading to increased oxidative stress that affects sperm quality during spermatogenesis. Moringa oleifera, rich in antioxidants, has been proven effective in improving sperm quality through several studies. This study aims to evaluate the influence of moringa leaf extract on sperm morphology and the reduction of blood sugar levels in Sprague Dawley white rats (Rattus norvegicus) induced by alloxan. Fasting blood sugar tests showed that rats induced with alloxan without moringa leaf extract had the highest blood sugar levels among the groups. In contrast, the negative control and treatment groups with moringa leaf extract successfully maintained blood sugar levels at normal levels. Normal sperm morphology reached 94.5% in the treatment group with the highest dose of moringa leaf extract. The results of the study indicate a significant relationship between blood sugar levels and sperm morphology in alloxan-induced white rats after the administration of moringa leaf extract. Moringa oleifera has the potential to be a therapeutic intervention to improve sperm quality and control blood sugar levels in hyperglycemic conditions.AbstrakPeningkatan kadar gula darah dapat dipicu oleh peningkatan asupan atau resistensi insulin menyebabkan peningkatan stres oksidatif yang mempengaruhi kualitas sperma selama spermatogenesis. Tanaman kelor (Moringa oleifera), tumbuhan yang kaya akan antioksidan, telah terbukti efektif dalam meningkatkan kualitas sperma melalui beberapa penelitian. Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak daun kelor terhadap morfologi sperma dan pengurangan kadar gula darah pada tikus putih Sprague Dawley (Rattus norvegicus) yang diinduksi aloksan. Uji gula darah puasa menunjukkan bahwa tikus yang diinduksi aloksan tanpa perlakuan ekstrak daun kelor memiliki kadar gula darah tertinggi di antara kelompok-kelompok lainnya. Sebaliknya, kelompok kontrol negatif dan kelompok perlakuan dengan ekstrak daun kelor berhasil menjaga kadar gula darah pada tingkat normal. Morfologi sperma normal mencapai 94,5% pada kelompok perlakuan dengan dosis 400 mg/kgBB ekstrak daun kelor. Kesimpulan yang didapatkan pada penelitian ini berkaitan dengan temuan hubungan signifikan antara kadar gula darah dan morfologi sperma pada tikus putih yang diinduksi aloksan setelah pemberian ekstrak daun kelor. Tanaman kelor (Moringa oleifera) memiliki potensi sebagai intervensi terapeutik untuk meningkatkan kualitas sperma dan mengendalikan kadar gula darah dalam kondisi hiperglikemia.
Analysis of Turtle Conservation Activities Effectiveness on Kelapa Dua Island, Kepulauan Seribu
Authors: Gulo Graciella Stevani , Tumuyu Sri Setiawati , Patria Mufti Petala
Published: September 2024

AbstractThe exploitation of turtles has resulted in a decline in the turtle population. The relocation of turtle eggs from nesting habitats is a widely accepted conservation practice. This research aims to analyze the effectiveness of turtle conservation activities on Kelapa Dua Island. The study adopts a mixed-methods approach, collecting primary data through field observations and interviews and secondary data from the Kepulauan Seribu National Park Office (BTNKpS). The collected data includes information on turtle nest monitoring activities, turtle preservation techniques, and the hatching success rate. The research results show that the hawksbill turtle (Eretmochelys imbricata) is the most commonly found turtle species. The average hatching success rate over the past six years is 71.98%. This value can still be optimized to reach 80% by establishing hatcheries on the nesting islands or islands near the nesting sites. Through this strategy, monitoring can be conducted more regularly, the turtle egg relocation process can be carried out relatively quickly, and vibrations or shocks to the turtle eggs during transportation can be minimized, thus increasing the hatching success rate. Regular monitoring of the environmental conditions of the artificial nests, including temperature, pH, and humidity, is also essential to improve the hatching percentage.AbstrakEksploitasi penyu telah menyebabkan penurunan populasi penyu. Relokasi telur penyu dari habitat penetasan adalah praktik konservasi yang umum diterima. Penelitian ini bertujuan untuk menganalisis efektivitas kegiatan konservasi penyu di Pulau Kelapa Dua. Studi ini mengadopsi pendekatan metode campuran, mengumpulkan data primer melalui observasi lapangan dan wawancara serta data sekunder dari Balai Taman Nasional Kepulauan Seribu (BTNKpS). Data yang terkumpul meliputi informasi tentang kegiatan pemantauan sarang penyu, teknik pelestarian penyu, dan tingkat keberhasilan penetasan. Hasil penelitian menunjukkan bahwa penyu sisik (Eretmochelys imbricata) merupakan spesies penyu yang paling banyak ditemukan. Tingkat keberhasilan penetasan rata-rata selama enam tahun terakhir adalah 71,98%. Nilai ini masih bisa dioptimalkan hingga mencapai 80% dengan mendirikan hatchery di pulau-pulau peneluran atau pulau-pulau yang berdekatan dengan lokasi peneluran. Melalui strategi ini, pemantauan dapat dilakukan lebih rutin, proses relokasi telur penyu dapat dilakukan dengan relatif cepat, dan getaran atau benturan pada telur penyu selama proses transportasi dapat diminimalkan, sehingga meningkatkan tingkat keberhasilan penetasan. Pemantauan teratur terhadap kondisi lingkungan sarang buatan, termasuk suhu, pH, dan kelembaban, juga penting untuk meningkatkan persentase penetasan.
The war of the Russian Empire against Ukraine: The most dangerous phase of the post-communist transition
Authors: Mihályi Péter , Szelényi Iván
Published: September 2024

We believe that the causes of the Russian-Ukrainian war can be understood as part of the post-communist transition. From the perspective of Putin's Russia, compared to the United States and China, the last three decades have been a failure on the economic growth front. Hence Putin's desire to restore as much as possible the Soviet Union, a multi-ethnic confederation of people built on communist ideology. But there is a contradiction here that neither public opinion nor Russian leaders can see. The Russian leadership cannot legitimise its current power and its ambitions to change the status quo by anything other than appealing to Russian national interests. This cannot be done without a communist ideology, because the Slavophile, ethno-nationalist, Pravoslav ideology and Putin's cult of personality are unacceptable to all other ethnic groups in the region.
Bone-inspired dynamically adaptive materials: Current efforts and future opportunities
Authors: Kitchen Grant , Sun Bohan , Kang Sung Hoon
Published: September 2024

The natural world contains a diverse range of solutions that allows for living organisms to dynamically adapt their structure and mechanical properties to meet environmental demands. For example, coral reef is able to accumulate reinforcing calcium carbonate from wave agitation and water current that stabilizes gaps in the structure and increases the reef density and strength through diagenetic reef cementation. Bone responds to repeated stress by translating deformations and fluid movement in the bone matrix into cellular signals that trigger bone formation through mechanotransduction. Utilizing these mechanisms as inspiration, synthetic materials have been developed that utilize stress-generated piezoelectric charges to attract mineral ions to form reinforcing mineral layers that can repair defects and damage over time and extend material lifetime. In this article, we examine natural adaptive processes that give inspiration for new synthetic materials with similar dynamic adaptive properties. We also introduce the capabilities of existing bioinspired synthetic materials, current challenges these systems face, potential application areas of this technology, and future research opportunities of these adaptive materials.

Graphical abstract
Problem bankructwa państwa
Authors: Kasperowicz-Stępień Alicja
Published: September 2024

Financial problems in many European countries have increasingly brought the issue of state bankruptcy to the fore. The rapid increase in a country's debt to GDP ratio can cause difficulties in the use of debt and thus reduce the country's creditworthiness. This paper presents the problem of state bankruptcy and debt restructuring methods used in the global economy.
Proces kształtowania projakościowego zarządzania organizacją
Authors: Łukasiński Wiesław
Published: September 2024

In the era of the market economy, quality has become one of the most basic categories determining an organisation's level of competitiveness. The complex, turbulent and demanding environment makes it necessary to adapt appropriately, while to restructure an organisation it is necessary to improve it systematically and to promote its adaptation to changes. The aim of the article is to show the process of creating pro-qualitative management at an organisation, which should be perceived as a determinant of the permanent success of an organisation understood as its ability to develop effective and efficient responses to identified needs and expectations that arise in its environment over the long term.
Consciousness: A Tangled Hierarchy
Authors: Poggi Peter
Published: September 2024

Consciousness is one of the greatest unsolved mysteries of the brain. The simple and yet fundamental question, “How do we have subjective experience?” remains a matter of great debate among neuroscientists. These debates have generated some challenges for consciousness research, namely the hard problem—do normal scientific approaches work for consciousness— and the binding problem—how are sensory inputs experienced in a unified manner? Historically, consciousness has been studied by searching for the neural correlates of consciousness which are defined as the minimal brain areas jointly necessary for conscious experience. One of the most popular experimental paradigms used to investigate the neural correlates of consciousness is binocular rivalry. In binocular rivalry, separate images are simultaneously presented to each eye and perception vacillates between them, providing a way of determining which neural changes are due to shifts in perceptual consciousness rather than changes in stimuli. As the research progressed, however, scientists realized that finding correlates of consciousness was insufficient and that explanatory theories of consciousness were needed to make further progress. This review article aims to introduce the field of consciousness research by presenting some of the core challenges to the field: tracing the search for the neural correlates of consciousness through the lens of binocular rivalry, and exploring four popular theories of consciousness. These are higher-order theory, global neuronal workspace theory, integrated information theory, and predictive processing. It concludes with a glance at the future directions of research that aim to resolve the beguiling phenomenon of consciousness.
Terminological Problems in the Field of Reproductions of Museum Objects
Authors:   Kemerovo State University of Culture and the Arts, Abramova Polina V. , Talipov Roman M. ,   Tomskaya Pisanitsa Museum Preserve
Published: September 2024

The article is devoted to the problems of using reproductions of authentic objects in museum activities and issues of terminological designation of their various types, as well as issues of their classification. There is no uniformity in terminology in the field of recreated originals. This is due to the ambiguity of concepts and the fact that copies of authentic objects are used in various fields of scientific activity. It is advisable to systematize the types of reproductions and bring to uniformity the terms designating them, focusing on the specifics of the original, the method and completeness of the transfer of the attributive characteristics of the original and, in some cases, on the method of manufacturing a newly made object. Ambiguous terms such as copy, remodel and reconstruction, when referring to reproductions of museum objects, should be assigned to their specific types.
Association of transmural dispersion of ventricular repolarization (Tpeak-Tend interval) with components of metabolic syndrome: data from the ESSE-RF3
Authors: Garbuzova E. V. , Kuznetsov A. A. , Nesterets A. M. , Khudyakova A. D. , Shramko V. S. , Imaeva A. E. , Muromtseva G. A. , Balanova Yu. A. , Simonova G. I.
Published: September 2024

Aim. To study the associations of the Tpeak-Tend interval (TpTe) with components of metabolic syndrome (MS) in a sample of Novosibirsk residents.

Material and methods. The study included 1042 residents of Novosibirsk (510 (48,9%) men) aged 35-74 years. The examination included the collection of demographic and social data, anthropometry, blood pressure (BP) measurement, and electrocardiography (ECG). MS was determined according to the 2013 criteria. The TpTe interval from the peak, as the maximum positive or negative T wave deviation, to the end of the T wave, was measured manually in lead V5. The corrected TpTe (cTpTe) interval was used in the study.

Results. The cTpTe is inversely associated with female sex (B 3,390, 95% confidence interval (CI): (-5,516-2,504), p=0,001). The cTpTe interval is associated with a blood pressure (BP) ≥140/90 mm Hg (B 3,154, 95% CI: (1,614-4,688), p=0,001), low-density lipoprotein cholesterol (LDL-C) >3,0 mmol/l (B 1,818, 95% CI: (0,409-3,544), p=0,030), regardless of other MS components, sex and age. The cTpTe interval was higher in individuals with BP ≥140/90 mm Hg compared with individuals with BP <140/90 mm Hg (69,08 95% CI: 67,59-70,66 vs 65,93 95% CI: 64,60-67,24; p=0,001), and in persons with LDL-C >3,0 mmol/l (68,41 95% CI: 67,11-69,63 vs 66,60 95% CI: 65,02-68,23; p=0,023), compared with individuals with LDL-C <3,0 mmol/l.

Conclusion. The cTpTe interval, considered as an indicator of transmural dispersion of ventricular repolarization, is shorter in women than in men and is associated with hypertension and atherogenic dyslipidemia, regardless of other MS components.
Hematologic mask of infective endocarditis as a cause of fever of unknown origin: a case report
Authors: Lutokhina Yu. A. , Andrushchishina T. B. , Erdniev T. N. , Mekhtieva G. A. , Petushkov I. L. , Yasneva A. S. , Blagova O. V.
Published: September 2024

Fever of unknown origin (FUO), despite the wide diagnostic potential of modern medicine, remains a difficult problem for clinicians. Often, making a correct diagnosis requires a comprehensive examination of the patient, as well as the joint work of doctors from different specialties.

A 57-year-old male patient was hospitalized due to an episode of loss of consciousness, unmotivated weight loss and daily evening temperature rises to 38-39о C, accompanied by chills and increased sweating. Previously, he was examined by a general practitioner, a cardiologist, and repeatedly by a hematologist. There was no evidence of an infectious disease, arrhythmias, multiple myeloma, lymphoproliferative disorders. Monoclonal gammopathy of undetermined significance (MGUS) was diagnosed. Blood tests revealed neutrophilia (9800 cells/ μl) and moderate anemia. The patient was hospitalized to determine the FUO cause. Heart auscultation revealed a systolic murmur in the mitral valve, which was previously absent. Echocardiography revealed a mobile masses on the mitral valve, severe mitral regurgitation, and therefore infective endocarditis was diagnosed. Empirical antibiotic therapy with ceftriaxone and levofloxacin was administered. Further blood culture revealed growth of a HACEK representative Aggregatibacter actinomycetemcomitans, sensitive to both drugs. Examination established the odontogenic nature of endocarditis. During treatment, stable normothermia and significant blood count improvement were achieved. However, fluoroquinolone therapy led to tendinopathy. Due to persistent grade 3 mitral regurgitation, the patient underwent routine mitral valve replacement. Further follow-up revealed satisfactory condition of the patient.

A feature of this case is the atypical course of infective endocarditis, occurring under a hematological mask, which made its diagnosis difficult. When examining a FUO patient, infective endocarditis should be included in the range of possible causes, taking into account not only the typical clinical picture, but also the numerous masks of this disease.
Health literacy, including related vaccination, of the working Russian population: data from a survey on the Atria platform
Authors: Antsiferova A. A. , Lopatina M. V. , Kontsevaya A. V. , Ipatov P. V. , Drapkina O. M.
Published: September 2024

Health literacy (HL), including related vaccination, is an important health determinant. For the working population, it helps to maintain and improve their ability to work. Despite the clear benefits of vaccination, vaccine confidence has recently declined worldwide, which may lead to decreased vaccination coverage and a renewal of infectious diseases. Based on this, increasing the level of public health, including vaccination issues, is one of the preventive medicine tasks. Staff groups seem to be an effective place for implementing measures to improve the health and vaccination prevention of the working population.

Aim. To assess the level of public health, including vaccination issues, among the working Russian population using digital technologies.

Material and methods. The study was conducted online and included employees filling out a questionnaire on their own. The results were posted on the Atria digital platform, which is a tool for assessing and implementing corporate programs to improve employee health. HL was assessed using the updated 2019 Health Literacy Survey Questionnaire (HLS19-Q) adapted into Russian and validated. The study lasted 18 months (from December 2022 to May 2024).

Results. A total of 58357 employees took part in the study on the Atria digital platform to assess the public health level, of which 47044 (80,6%) were women. In general, workers had a predominantly excellent HL (n=39637, 67,9%), while in women it was 69,4% (n=32644). The insufficient HL varied slightly among workers of different age groups. The fewest workers with an excellent HL were recorded in the age group of 40-49 years (65,4%, n=11857), and the most among workers >60 years old (74,2%, n=3573). The study found that 43,3% of men and 56,2% of women are vaccinated against influenza annually. Among those workers who are vaccinated against influenza annually, the highest HL rate was recorded among workers >60 years of age (63,4%, n=4188), and the lowest among workers <30 years of age (48,2%, n=4992). Workers with an excellent HL are predominantly vaccinated against influenza annually (77,8%, n=21306).

Conclusion. For the first time in the Russian Federation, a study was conducted to assess the HL level, including vaccination issues, among workers using digital technologies. The results obtained indicate that further measures are needed to increase the HL level of workers, including in terms of vaccination. Based on research data, methodological documents and corporate programs aimed at improving the current situation should be developed and implemented.
Current approaches to the treatment of hypertensive patients in view of modern guidelines
Authors: Polyakova E. A. , Konradi A. O. , Baranova E. I. , Galyavich A. S. , Ionin V. A. , Ostroumova O. D. , Skibitsky V. V. , Chumakova G. A.
Published: September 2024

The issues of diagnosis and treatment of hypertension (HTN), as well as the prevention of its complications, are an urgent problem in cardiology. On June 21, 2023, the Journal of Hypertension published guidelines on HTN from the European Society of Hypertension (ESH), which were first presented to the public at the annual European Hypertension Meetings on June 24, 2023 in Milan. This publication describes the highlights and key updates of the guidelines and outlines its clinical significance. Russian experts also discussed current problems of pathogenesis, diagnosis and treatment of HTN.
Response to an expert opinion on the article "Association between cardiovascular mortality and deprivation in the adult population of Russia"
Authors: Zelenina A. A. , Shalnova S. A. , Maksimov S. A.
Published: September 2024

Response to an expert opinion on the article "Association between cardiovascular mortality and deprivation in the adult population of Russia", published in the Cardiovascular Therapy and Prevention 2024;23(3):3903, contains comments and explanations for a better understanding of issues raised in expert opinion.
GEOMETRIC MODELS FOR INCORPORATING SOLID ACCUMULATION AT THE NODES OF OPEN-CELL FOAMS
Authors: Maré E. , Woudberg S.
Published: September 2024

In open-cell foams, solid lumps are often present at the intersection of struts, known as the nodes. In this study models available in the literature that represent foams with solid accumulation at the nodes are investigated and used to obtain predictive equations for the permeability (for both the Darcy and Forchheimer flow regimes) and specific surface area for given porosity and average pore diameter values. The majority of the predictive equations proposed for the specific surface area based on these models are novel contributions. Furthermore, a method is proposed for incorporating solid lumps at the nodes into the existing foam (or three-strut) rectangular representative unit cell (RUC) model. The models obtained from the literature along with the node-adjusted RUC model are compared to one another and to relevant experimental data from the literature for foams that have accumulation of solid matter present at the nodes. The node-adjusted RUC model provides physically meaningful and satisfactory changes to the specific surface area and permeability predictions of the existing foam RUC model.
Numerical Simulation of Effects of Previous PVD Treatment on Second Vacuum-PVD Improvement
Authors: Bergado DT , Nghia-Nguyen T , Jamsawang P , Kovittayanon N , Rementilla J , Chao KC
Published: September 2024

The influence of the initial improvement through prefabricated vertical drains (PVD) and surcharge embankment on the second improvement by vacuum PVD has not been comprehensively explored in the existing literature. The expansion of the Second Bangkok International Airport (Suvarnabhumi Airport) underwent initial treatment with PVD and surcharge, followed by further soft ground improvement with vacuum PVD, which serves as a valuable case study for understanding the impact of the initial PVD improvement. This study highlights the effects of the initial PVD improvement through a comparison of two case studies: the first improvement by vacuum PVD on Taxiway Extension D at Zone 27 and the second vacuum PVD improvement on the Third Extension North at Zone 7. Extensive back analysis results reveal significantly higher flow parameters and reduced settlements for the second improvement at Zone 7 compared to the first improvement at Zone 27. The water contents, void ratios, and compression indices decreased while the undrained shear strengths and maximum past pressures increased. These results demonstrated the effectiveness of the vacuum PVD improvement with a modified field-distributed air-water separation system. Numerical studies further corroborated these findings and confirmed the observed crack patterns at the surface resulting from inward lateral movement.
The Status of Druze Studies and Launching the Druze Studies Journal (DSJ)
Authors: Hazran Yusri , Reed Marianne A. , Schäbler Birgit , Timani Hussam S. , Zeedan Rami
Published: September 2024

This essay discusses the evolution of Druze Studies and the inauguration of the Druze Studies Journal (DSJ), as well as encapsulates discussions from the "2023 Bilingual Interdisciplinary Virtual Symposium: Druze Studies: Past, Present, and Future." Initiated at the University of Kansas, this event marks a pivotal moment in researching the Druze, addressing the field’s expansion over the last two decades, and creating platforms like DSJ and the Druze Studies Project for scholarly exchange. Contributions range from digital publishing innovations to critical reevaluations of Druze Studies' scope and methodologies. Key discussions revolve around enhancing research continuity, overcoming interdisciplinary challenges, and navigating ethical considerations surrounding sacred community beliefs. This collective effort underscores the importance of DSJ as a medium for fostering academic dialogue, broadening Druze Studies’ reach, and promoting a deeper, more inclusive understanding of the Druze community's historical and contemporary contexts.
Evaluation of Tensile Bond Strength of Nanoparticle Reinforced Soft Liner Materials: A Pilot Study
Authors: Avukat Esra Nur , Topcu Ersöz Mirac Berke , Akay Canan , Mumcu Emre
Published: September 2024

OBJECTIVE: The aim of this study is to evaluate the tensile bond strength between polymethyl methacrylate (PMMA) surfaces and autopolymerized silicon-based soft lining materials with 1% w/w Titanium dioxide (TiO2) and Hydroxyapatite (HA) nanoparticles added.
MATERIALS AND METHODS: For the tensile test, 60 pieces of acrylic (Meliodent, Bayer Dental, Newbury, England) samples of 30 × 10 × 10 mm3 dimensions were prepared using metal molds. Acrylic surfaces were sanded with silicon carbide sandpapers of 500, 1000, 1500, and 2000 grids to ensure standardization. After the samples were placed back in the metal mold, adhesive (Detax, Germany)
was applied to the surfaces that would come into contact with the soft lining. Soft lining materials (Mollosil, Detax, Ettlingen, Germany) to which 1% by weight TiO2 and 1% HA nanoparticles were added were polymerized by placing them between two acrylic blocks. For the tensile test, a total of 30 samples were obtained, with 10 samples in each group (n=10). The specimens were placed on the holder end of the universal test device and force was applied until failure occurred.
RESULTS: The tensile bond strength (0,86 ± 0,21 MPa) in the TiO2 nanoparticle-added group was found to be significantly higher than the control group (0,65 ± 0,14 MPa) (p<0.05). There is no significant difference between the control group and the HA nanoparticle-added group (0.65 ± 0.1 MPa) (p˃0.05).
CONCLUSION: It was observed that the addition of nanoparticles increased the tensile strength. However, further studies are needed to evaluate the effect of nanoparticle addition on other mechanical and physical properties of soft liners.
Diş hekimliği uygulamalarında soğuk atmosferik plazma (CAP)
Authors: Çınar Acar Berat , Yuksekdag Zehranur , Açar Elif , Şahin Tuğba , Yüksekdağ Hazer
Published: September 2024

Plazma, maddenin dördüncü hali olarak bilinmektedir. Tıbbi implantların veya polimer filmlerin yüzey modifikasyonları için, farklı enerji yoğunluk seviyelerine sahip termal veya termal olmayan farklı kaynakları kullanılabilmektedir. Bu derleme çalışmasında, Soğuk Atmosferik Plazma (CAP) sistemlerinin diş hekimliği uygulamalarındaki kullanılabilirliği üzerine odaklanılmıştır. Plazmanın potansiyel antibakteriyel özellikleri, onu klinik bilimlerde yaygın olarak kullanılan bir dezenfektan haline getirmektedir. Bakterileri yok ederek diş hekimliğinde kullanılan aletleri sterilize etmedeki etkinliği, geleneksel yöntemlere göre diş kavite dekontaminasyonundaki avantajı, kök kanal dezenfeksiyonu, biyofilm tabakasının ortadan kaldırılması, diş beyazlatma üzerindeki etkileri nedeniyle soğuk atmosferik plazma son yıllarda diş hekimliği alanında yeni bir terapötik yöntem olarak ortaya çıkmıştır. Soğuk plazmanın tıp/diş hekimliği veya diğer alanlarda gösterdiği etkilerinin hepsinde reaktif oksijen ve azot türlerinin etkili olduğu kabul edilmektedir. Düşük sıcaklıkta reaktif türlerin mevcudiyeti nedeniyle, termal olmayan plazmaların biyolojik etkileri tıbbi alanda uygulama için umut verici görülmektedir. Bu nedenle CAP diş hekimliğinin karyoloji, periodontoloji, endodonti ve ağız patolojisi gibi birçok alanında uygulanabilme potansiyeline sahiptir.
Assessment of oral hygiene habits and periodontal status of patients during and after orthodontic treatment
Authors: Şahin Tuğba
Published: September 2024

OBJECTIVE: This study evaluated the relationship between orthodontic treatment, oral hygiene practices, and periodontal health in individuals undergoing or completed orthodontic treatment.
MATERIALS AND METHOD: Systemically healthy patients undergoing or completed stable orthodontic treatment were included in the study. The periodontal status of 142 participants was determined using a comprehensive oral hygiene questionnaire and clinical oral examinations to assess various periodontal indices. Chi-square and t-tests were used for statistical analyses to compare periodontal status metrics between groups.
RESULTS: Statistical analyses revealed no significant differences between oral hygiene habits, periodontal indices, or periodontal status between the ongoing treatment (OT) and post-orthodontic treatment (PT) groups (p>0.05). However, significant differences
were noted in attachment level, dental visit frequency, and reasons for visits between the OT and PT groups (p<0.05). While participants generally showed similar oral hygiene awareness and practices, differences arose in toothbrushing times during orthodontic treatment and adherence to orthodontist recommendations.
CONCLUSION: This study investigated the effect of OT on oral health and concluded that OT did not change oral hygiene habits but affected attachment levels. Orthodontists should consistently guide patients on oral hygiene and managing clinical attachment loss. In these cases, the patient should be referred to a periodontist when necessary.
Renewed Theories and Discourses of 21st Century; City Planning and Housing Design COVID-19 and Beyond, Sustainable, and Green Design
Authors: Hülya Coskun
Published: September 2024

This research delves into the future housing theories of the 21st century, focusing on recent transformations in both urban planning and housing projects and models. Despite the world's anticipation of a vast sustainable transformation since the late 20th century, the first quarter of the 21st century was confronted with an unexpected event: humanity found itself amidst a pandemic that significantly transformed the world. The post-COVID-19 era has guided significant and enduring changes in various aspects from urban planning to living styles, working patterns, housing models, and typologies. This research presents renewed perspectives, based on theoretical dialogues, and discourses that aim to understand the transformation period with recent events specifically housing. The research also includes the perspective of housing in the past aims to contribute to comprehension of this new era and aid in shaping future urban and housing planning strategies. The theoretical basis is to investigate new methods and techniques in urban, and housing planning that have addressed climate-related issues since the 1980s and the subsequent pandemic period. According to the findings obtained in the research, COVID-19 and sustainability initially considered different phenomena, pandemic is essentially triggered and contributed to sustainable city planning, and housing design. While the public perception often distinguishes between COVID-19 and drivability as distinct design concepts, the research reveals a nuanced reality. Despite apparent differences, it is discerning that similar ideas and design principles aim for a healthier housing concept in airier, and greener areas both in terms of housing planning, and models. This intricates a close conceptual relationship between pandemic-induced design adaptations and sustainable concepts underscores the complexity of contemporary urban and housing planning paradigms.
Transcardial Perfusion in Mice for Synaptic Evaluation and QUantification by Imaging Nanostructure (SEQUIN) Analysis v1
Authors: Kumar Sah Saroj , Biederer Thomas
Published: September 2024

This protocol details the method for transcardial perfusion in mice for Synaptic Evaluation and QUantification by Imaging Nanostructure (SEQUIN) Analysis. This transcardial perfusion can also be used for immunohistochemical analysis of p-Syn staining along with synaptic proteins.
Выделение, пробоподготовка и секвенирование тотальной ДНК грибов на Nanopore MinION v1
Authors: Zvyagina Elena , Filippova Nina
Published: September 2024

[EN] Protocols for sampling, sample preparation, and sequencing on the Nanopore MinION platform. The target material is total fungal DNA (amplicons) from soil and other substrates. This protocol includes the sampling conditions and DNA extraction methods for metabarcoding tasks, as well as a more or less literal translation of the protocol for the Native Barcoding Kit 24 V14 (SQK-NBD114.24) and the instructions provided on the Nanopore website to Russian. The text has been supplemented with the experience of the laboratory "Molecular Genetic Methods in Biodiversity Studies" in the context of our research objectives. [RU] Протоколы отбора, подготовки проб и секвенирования на платформе Nanopore MinION. В качестве объекта используется тотальная ДНК (ампликоны) грибов из почвы и других субстратов. Данный протокол содержит условия отбора проб и выделения ДНК для задач метабаркодинга, а также более или менее дословный перевод протокола для Native Barcoding Kit 24 V14 (SQK-NBD114.24) и инструкций, размещенных на сайте Nanopore. Текст был дополнен опытом работы лаборатории "Молекулярно-генетических методов в изучении биоразнообразия" в рамках наших исследовательских задач.