bluuebunny/crossref_metadata_2025 huggingface dataset:
Bidirectional causality between idiopathic sudden sensorineural hearing loss and depression: a Mendelian randomization study
Authors: Wu Chuanyu , Yu Ya , Zhao Tongtong , Xie Hui
Published: June 2024

Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) is a sudden onset, unexplained sensorineural hearing loss. Depression is a common mental disorder and a leading cause of disability. Here, We used a two-sample Mendelian randomization approach using pooled statistics from genome-wide association studies of ISSHL (1491 cases, 196,592 controls) and depression (23,424 cases, 192,220 controls) in European populations. This study investigated the bidirectional relationship between single nucleotide polymorphisms associated with depression and ISSHL using inverse variance weighting.Additional sensitivity analyses, such as Mendelian randomization-Egger (MR-Egger), weighted median estimates, and leave-one-out analysis, were performed to assess the reliability of the findings. Significant causal association between genetic susceptibility to ISSHL and depression in a random-effects IVW approach (OR = 1.037, 95% CI = 1.004–1.072, P = 0.030). In contrast, genetic depression was not risk factors for ISSHL (OR = 1.134, 95% CI = 0.871–1.475, P = 0.350). After validation by different MR methods and the sensitivity analysis, all of the above results are consistent. The evidence we have gathered suggests a causal relationship between ISSHL and depression. The presence of the former induces or further exacerbates the latter, whereas a similar situation does not exist when the latter is an influencing factor.
Variable data structures and customized deep learning surrogates for computationally efficient and reliable characterization of buried objects
Authors: Yurt Reyhan , Torpi Hamid , Kizilay Ahmet , Koziel Slawomir , Mahouti Peyman
Published: June 2024

In this study, in order to characterize the buried object via deep-learning-based surrogate modeling approach, 3-D full-wave electromagnetic simulations of a GPR model have been used. The task is to independently predict characteristic parameters of a buried object of diverse radii allocated at different positions (depth and lateral position) in various dispersive subsurface media. This study has analyzed variable data structures (raw B-scans, extracted features, consecutive A-scans) with respect to computational cost and accuracy of surrogates. The usage of raw B-scan data and the applications for processing steps on B-scan profiles in the context of object characterization incur high computational cost so it can be a challenging issue. The proposed surrogate model referred to as the deep regression network (DRN) is utilized for time frequency spectrogram (TFS) of consecutive A-scans. DRN is developed with the main aim being computationally efficient (about 13 times acceleration) compared to conventional network models using B-scan images (2D data). DRN with TFS is favorably benchmarked to the state-of-the-art regression techniques. The experimental results obtained for the proposed model and second-best model, CNN-1D show mean absolute and relative error rates of 3.6 mm, 11.8 mm and 4.7%, 11.6% respectively. For the sake of supplementary verification under realistic scenarios, it is also applied for scenarios involving noisy data. Furthermore, the proposed surrogate modeling approach is validated using measurement data, which is indicative of suitability of the approach to handle physical measurements as data sources.
Polyphasic identification of Rhizopus oryzae and evaluation of physical fermentation parameters in potato starch processing liquid waste for β-glucan production
Authors: Anchundia Miguel , León-Revelo Gualberto , Santacruz Stalin , Torres Freddy
Published: June 2024

Β-glucans are polysaccharide macromolecules that can be found in the cell walls of molds, such as Rhizopus oryzae. They provide functional properties in food systems and have immunomodulatory activity, anticancer, and prebiotic effects; reduce triglycerides and cholesterol; and prevent obesity, among others benefits. Furthermore, potato starch production requires a large amount of water, which is usually discharged into the environment, creating problems in soils and bodies of water. The physical parameters to produce β-glucans were determined, liquid waste from potato starch processing was used and native Rhizopus oryzae was isolated and identified from cereal grains. The isolates grew quickly on the three types of agars used at 25 °C and 37 °C, and they did not grow at 45 °C. Rhizopus oryzae M10A1 produced the greatest amount of β-glucans after six days of culture at 30 °C, pH 6, a stirring rate of 150 rpm and a fermentation volume of 250 mL. By establishing the physical fermentation parameters and utilizing the liquid waste from potato starch, Rhizopus oryzae M10A1 yielded 397.50 mg/100 g of β-glucan was obtained.
Improving urban emergency medical service systems through brownfield transformation in Huangshi, China
Authors: Liu Zhiping , Feng Yingxue , Li Jing , Tao Haoyu , Liu Zhen , Li Xiaodan
Published: June 2024

A comprehensive emergency medical service (EMS) system significantly enhances a city’s capacity to prevent and mitigate disasters. Using Huangshi as a case study, this research evaluated the service radium coverage rate of the current EMS system by examining its transport capacity, population density, and prevalence rate, finding it to be only 61.49% with an inefficient spatial layout. To address this, we proposed transforming urban brownfields into EMS parks. By selecting the most suitable brownfields based on capacity and service radius, we increased the coverage rate to 90.21%. We introduced a new "consultation-referral" model, where existing EMS facilities serve as pre-diagnosis and triage centers, and the urban brownfield EMS parks function as isolation and centralized treatment centers. GIS network analysis confirmed the feasibility, showing all transit times to be under 30 min. The methodology outlined in this study—comprising "demand assessment, supply optimization, and feasibility verification"—not only strengthens the city’s EMS system but also facilitates the renewal of urban brownfields. This approach can serve as a valuable reference for enhancing EMS systems in other cities.
Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis
Authors: Torres-Puig Sergi , Crespo-Pomar Silvia , Akarsu Hatice , Yimthin Thatcha , Cippà Valentina , Démoulins Thomas , Posthaus Horst , Ruggli Nicolas , Kuhnert Peter , Labroussaa Fabien , Jores Jörg
Published: June 2024

The Mycoplasma Immunoglobulin Binding/Protease (MIB-MIP) system is a candidate ‘virulence factor present in multiple pathogenic species of the Mollicutes, including the fast-growing species Mycoplasma feriruminatoris. The MIB-MIP system cleaves the heavy chain of host immunoglobulins, hence affecting antigen-antibody interactions and potentially facilitating immune evasion. In this work, using -omics technologies and 5’RACE, we show that the four copies of the M. feriruminatoris MIB-MIP system have different expression levels and are transcribed as operons controlled by four different promoters. Individual MIB-MIP gene pairs of M. feriruminatoris and other Mollicutes were introduced in an engineered M. feriruminatoris strain devoid of MIB-MIP genes and were tested for their functionality using newly developed oriC-based plasmids. The two proteins are functionally expressed at the surface of M. feriruminatoris, which confirms the possibility to display large membrane-associated proteins in this bacterium. However, functional expression of heterologous MIB-MIP systems introduced in this engineered strain from phylogenetically distant porcine Mollicutes like Mesomycoplasma hyorhinis or Mesomycoplasma hyopneumoniae could not be achieved. Finally, since M. feriruminatoris is a candidate for biomedical applications such as drug delivery, we confirmed its safety in vivo in domestic goats, which are the closest livestock relatives to its native host the Alpine ibex.
Unveiled reactivity of masked diformylmethane with enamines forming resonance-assisted hydrogen bonding leads to di-meta-substituted pyridines
Authors: Yi Sihyeong , Lee Ji Hyae , Cho Hana , Vaithegi Kannan , Yi Dawon , Noh Sijun , Park Seung Bum
Published: June 2024

Pyridine, an essential structure in drug development, shows a wide array of bioactivities according to its substitution patterns. Among the bioactive pyridines, meta-substituted pyridines suffer from limited synthetic approaches despite their significance. In this study, we present a condensation-based synthetic method enabling the facile incorporation of biologically relevant functional groups at the meta position of pyridine. This methodology unveiled the concealed reactivity of 3-formyl(aza)indoles as diformylmethane analogs for synthesizing dissymmetric di-meta-substituted pyridines without ortho and para substitutions. Furthermore, we uncovered resonance-assisted hydrogen bonding (RAHB) as the requirement for the in situ generation of enamines, the key intermediates of this transformation. Successful development of the designed methodology linked to wide applications—core remodeling of natural products, drug–natural product conjugation, late-stage functionalization of drug molecules, and synthesis of the regioisomeric CZC24832. Furthermore, we discovered anti-inflammatory agents through the functional evaluation of synthesized bi-heteroaryl analogs, signifying the utility of this methodology.
Competitive protein recruitment in artificial cells
Authors: van Veldhuisen Thijs W. , Verwiel Madelief A. M. , Novosedlik Sebastian , Brunsveld Luc , van Hest Jan C. M.
Published: June 2024

Living cells can modulate their response to environmental cues by changing their sensitivities for molecular signals. Artificial cells are promising model platforms to study intercellular communication, but populations with such differentiated behavior remain underexplored. Here, we show the affinity-regulated exchange of proteins in distinct populations of coacervate-based artificial cells via protein-protein interactions (PPI) of the hub protein 14-3-3. By loading different coacervates with different isoforms of 14-3-3, featuring varying PPI affinities, a client peptide is directed to the more strongly recruiting coacervates. By switching affinity of client proteins through phosphorylation, weaker binding partners can be outcompeted for their 14-3-3 binding, inducing their release from artificial cells. Combined, a communication system between coacervates is constructed, which leads to the transport of client proteins from strongly recruiting coacervates to weakly recruiting ones. The results demonstrate that affinity engineering and competitive binding can provide directed protein uptake and exchange between artificial cells.
Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases
Authors: Li Tuo , Borg Annika J. E. , Krammer Leo , Weber Hansjörg , Breinbauer Rolf , Nidetzky Bernd
Published: June 2024

Glycosylated derivatives of natural product polyphenols display a spectrum of biological activities, rendering them critical for both nutritional and pharmacological applications. Their enzymatic synthesis by glycosyltransferases is frequently constrained by the limited repertoire of characterized enzyme-catalyzed transformations. Here, we explore the glycosylation capabilities and substrate preferences of newly identified plant uridine diphosphate (UDP)-dependent glycosyltransferases (UGTs) within the UGT72 and UGT84 families, with particular focus on natural polyphenol glycosylation from UDP-glucose. Four UGTs are classified according to their phylogenetic relationships and reaction products, identifying them as biocatalysts for either glucoside (UGT72 enzymes) or glucose ester (UGT84 members) formation from selected phenylpropanoid compounds. Detailed kinetic evaluations expose the unique attributes of these enzymes, including their specific activities and regio-selectivities towards diverse polyphenolic substrates, with product characterizations validating the capacity of UGT84 family members to perform di-O-glycosylation on flavones. Sequence analysis coupled with structural predictions through AlphaFold reveal an unexpected absence of a conserved threonine residue across all four enzymes, a trait previously linked to pentosyltransferases. This comparative analysis broadens the understood substrate specificity range for UGT72 and UGT84 enzymes, enhancing our understanding of their utility in the production of natural phenolic glycosides. The findings from this in-depth characterization provide valuable insights into the functional versatility of UGT-mediated reactions.
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities
Authors: Ramberger Evelyn , Sapozhnikova Valeriia , Ng Yuen Lam Dora , Dolnik Anna , Ziehm Matthias , Popp Oliver , Sträng Eric , Kull Miriam , Grünschläger Florian , Krüger Josefine , Benary Manuela , Müller Sina , Gao Xiang , Murgai Arunima , Haji Mohamed , Schmidt Annika , Lutz Raphael , Nogai Axel , Braune Jan , Laue Dominik , Langer Christian , Khandanpour Cyrus , Bassermann Florian , Döhner Hartmut , Engelhardt Monika , Straka Christian , Hundemer Michael , Beule Dieter , Haas Simon , Keller Ulrich , Einsele Hermann , Bullinger Lars , Knop Stefan , Mertins Philipp , Krönke Jan
Published: June 2024

Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, and better risk stratification as well as new therapies are therefore highly needed. The proteome of MM has not been systematically assessed before and holds the potential to uncover insight into disease biology and improved prognostication in addition to genetic and transcriptomic studies. Here we provide a comprehensive multiomics analysis including deep tandem mass tag-based quantitative global (phospho)proteomics, RNA sequencing, and nanopore DNA sequencing of 138 primary patient-derived plasma cell malignancies encompassing treatment-naive MM, plasma cell leukemia and the premalignancy monoclonal gammopathy of undetermined significance, as well as healthy controls. We found that the (phospho)proteome of malignant plasma cells are highly deregulated as compared with healthy plasma cells and is both defined by chromosomal alterations as well as posttranscriptional regulation. A prognostic protein signature was identified that is associated with aggressive disease independent of established risk factors in MM. Integration with functional genetics and single-cell RNA sequencing revealed general and genetic subtype-specific deregulated proteins and pathways in plasma cell malignancies that include potential targets for (immuno)therapies. Our study demonstrates the potential of proteogenomics in cancer and provides an easily accessible resource for investigating protein regulation and new therapeutic approaches in MM.
In vivo organoid growth monitoring by stimulated Raman histology
Authors: Sarri Barbara , Chevrier Véronique , Poizat Flora , Heuke Sandro , Franchi Florence , De Franqueville Louis , Traversari Eddy , Ratone Jean-Philippe , Caillol Fabrice , Dahel Yanis , Hoibian Solène , Giovannini Marc , de Chaisemartin Cécile , Appay Romain , Guasch Géraldine , Rigneault Hervé
Published: June 2024

Patient-derived tumor organoids have emerged as a crucial tool for assessing the efficacy of chemotherapy and conducting preclinical drug screenings. However, the conventional histological investigation of these organoids necessitates their devitalization through fixation and slicing, limiting their utility to a single-time analysis. Here, we use stimulated Raman histology (SRH) to demonstrate non-destructive, label-free virtual staining of 3D organoids, while preserving their viability and growth. This novel approach provides contrast similar to conventional staining methods, allowing for the continuous monitoring of organoids over time. Our results demonstrate that SRH transforms organoids from one-time use products into repeatable models, facilitating the efficient selection of effective drug combinations. This advancement holds promise for personalized cancer treatment, allowing for the dynamic assessment and optimization of chemotherapy treatments in patient-specific contexts.
Deep learning-based virtual H& E staining from label-free autofluorescence lifetime images
Authors: Wang Qiang , Akram Ahsan R. , Dorward David A. , Talas Sophie , Monks Basil , Thum Chee , Hopgood James R. , Javidi Malihe , Vallejo Marta
Published: June 2024

Label-free autofluorescence lifetime is a unique feature of the inherent fluorescence signals emitted by natural fluorophores in biological samples. Fluorescence lifetime imaging microscopy (FLIM) can capture these signals enabling comprehensive analyses of biological samples. Despite the fundamental importance and wide application of FLIM in biomedical and clinical sciences, existing methods for analysing FLIM images often struggle to provide rapid and precise interpretations without reliable references, such as histology images, which are usually unavailable alongside FLIM images. To address this issue, we propose a deep learning (DL)-based approach for generating virtual Hematoxylin and Eosin (H&E) staining. By combining an advanced DL model with a contemporary image quality metric, we can generate clinical-grade virtual H&E-stained images from label-free FLIM images acquired on unstained tissue samples. Our experiments also show that the inclusion of lifetime information, an extra dimension beyond intensity, results in more accurate reconstructions of virtual staining when compared to using intensity-only images. This advancement allows for the instant and accurate interpretation of FLIM images at the cellular level without the complexities associated with co-registering FLIM and histology images. Consequently, we are able to identify distinct lifetime signatures of seven different cell types commonly found in the tumour microenvironment, opening up new opportunities towards biomarker-free tissue histology using FLIM across multiple cancer types.
Formation of chirality in propagating spin waves
Authors: Trevillian Cody , Tyberkevych Vasyl
Published: June 2024

A general approach to quantify chirality, or absence of parity symmetry, of spin waves has been developed and applied to spin waves propagating in obliquely magnetized ferromagnetic films. Using theoretical arguments and numerical calculations, it is shown that, upon increasing spin wave wavevector, initially achiral spin waves develop chiral properties through the “parity exchange” mechanism, which implies, in particular, that chiral spin waves appear in pairs. The most striking example of the parity exchange mechanism is the simultaneous formation of two chiral waves: the magnetostatic surface wave and the recently discovered heterosymmetric spin wave, which were previously considered independent of each other. Another manifestation of the parity exchange is the formation of strongly chiral waves near the anti-crossings of spin wave branches of unequal symmetry. These findings illustrate viable paths to engineering spin wave systems with prescribed chiral spectra that had not previously been considered.
Pixel-super-resolved lens-free quantitative phase microscopy with partially coherent illumination
Authors: Chen Yang , Wu Xuejuan , Lu Linpeng , Sun Jiasong , Zhang Runnan , Lin Wenhui , Chen Yufan , Trusiak Maciej , Gao Peng , Zuo Chao
Published: June 2024

Lens-free on-chip microscopy (LFOCM) has been widely utilized in digital pathology, drug screening, point-of-care testing (POCT), and quantitative phase imaging (QPI) due to its high throughput imaging capability and compactness. Initially, coherent laser sources were used in LFOCM to generate interference fringes to reconstruct the intensity and phase information of an object. The use of partially coherent light-emitting diodes (LEDs) in LFOCM offers a more portable and cost-effective alternative to conventional coherent illumination sources. However, the coherence-gating effect from a relatively low degree of coherence may cause a blur of high-frequency information in holograms, leading to an inaccurate object recovery. Thus, we present a pixel-super-resolved lens-free quantitative phase microscopy (PSR-LFQPM) with partially coherent illumination, which not only compensates for the impact of low coherence without increasing the volume of the system but also suppresses the theoretical Nyquist-Shannon sampling resolution limit imposed by the sensor pixel size (0.9 μm). Based on the partially coherent imaging model, we integrate the spatial coherence transfer function (SCTF) obtained from the pre-calibrated LED source distribution during the iteration process to obtain an accurate high-resolution recovery. Applying PSR-LFQPM to image living HeLa cells in vitro, we achieve real-time dynamic high-throughput QPI performance (half-pitch resolution of 780 nm with a 1.41-fold improvement compared to results without considering the effect of coherence) across a wide FOV (19.53 mm2). The proposed method provides a compact, low-cost, and high-throughput lens-free on-chip microscopy system for biomedical and POCT applications.
Advances on broadband and resonant chiral metasurfaces
Authors: Deng Qian-Mei , Li Xin , Hu Meng-Xia , Li Feng-Jun , Li Xiangping , Deng Zi-Lan
Published: June 2024

Chirality describes mirror symmetry breaking in geometric structures or certain physical quantities. The interaction between chiral structure and chiral light provides a rich collection of means for studying the chirality of substances. Recently, optical chiral metasurfaces have emerged as planar or quasi-planar photonic devices composed of subwavelength chiral unit cells, offering distinct appealing optical responses to circularly polarized light with opposite handedness. The chiroptical effects in optical metasurfaces can be manifested in the absorption, scattering, and even emission spectra under the circular polarization bases. A broadband chiroptical effect is highly desired for many passive chiral applications such as pure circular polarizers, chiral imaging, and chiral holography, in which cases the resonances should be avoided. On the other hand, resonant chiroptical responses are particularly needed in many situations requiring strong chiral field enhancement such as chiral sensing and chiral emission. This article reviews the latest research on both broadband and resonant chiral metasurfaces. First, we discuss the basic principle of different types of chiroptical effects including 3D/2D optical chirality and intrinsic/extrinsic optical chirality. Then we review typical means for broadband chiral metasurfaces, and related chiral photonic devices including broadband circular polarizers, chiral imaging and chiral holography. Then, we discuss the interaction between chiral light and matter enhanced by resonant chiral metasurfaces, especially for the chiral bound states in the continuum metasurfaces with ultra-high quality factors, which are particularly important for chiral molecule sensing, and chiral light sources. In the final section, the review concludes with an outlook on future directions in chiral photonics.
Spermatocytes have the capacity to segregate chromosomes despite centriole duplication failure
Authors: Skinner Marnie W , Simington Carter J , López-Jiménez Pablo , Baran Kerstin A , Xu Jingwen , Dayani Yaron , Pryzhkova Marina V , Page Jesús , Gómez Rocío , Holland Andrew J , Jordan Philip W
Published: June 2024

Centrosomes are the canonical microtubule organizing centers (MTOCs) of most mammalian cells, including spermatocytes. Centrosomes comprise a centriole pair within a structurally ordered and dynamic pericentriolar matrix (PCM). Unlike in mitosis, where centrioles duplicate once per cycle, centrioles undergo two rounds of duplication during spermatogenesis. The first duplication is during early meiotic prophase I, and the second is during interkinesis. Using mouse mutants and chemical inhibition, we have blocked centriole duplication during spermatogenesis and determined that non-centrosomal MTOCs (ncMTOCs) can mediate chromosome segregation. This mechanism is different from the acentriolar MTOCs that form bipolar spindles in oocytes, which require PCM components, including gamma-tubulin and CEP192. From an in-depth analysis, we identified six microtubule-associated proteins, TPX2, KIF11, NuMA, and CAMSAP1-3, that localized to the non-centrosomal MTOC. These factors contribute to a mechanism that ensures bipolar MTOC formation and chromosome segregation during spermatogenesis when centriole duplication fails. However, despite the successful completion of meiosis and round spermatid formation, centriole inheritance and PLK4 function are required for normal spermiogenesis and flagella assembly, which are critical to ensure fertility.
Electrochemical synthesis of β-difluoromethylamide compounds by N-benzenesulfonylacrylamide with difluorine reagents
Authors: Lei Zhi-Long , Ding Zong-Cang , Li Shu-Hui , Cui Fei-Hu , Tang Hai-Tao , Pan Ying-Ming
Published: June 2024

A mild and efficient electrochemical method for radical addition, cyclization, and migration reaction was described in this work.
Defect structure–electronic property correlations in transition metal dichalcogenide grain boundaries
Authors: Somay Srest , Balasubramanian Krishna
Published: June 2024

Grain boundaries in 2D materials present significant deformation potential in their vicinity leading to significant bandgap renormalization. We show that the effect of grain boundaries can be resolved to a small number of basis defect structures.
Liquid-jet photoemission spectroscopy as a structural tool: site-specific acid–base chemistry of vitamin C
Authors: Tomaník Lukáš , Pugini Michele , Mudryk Karen , Thürmer Stephan , Stemer Dominik , Credidio Bruno , Trinter Florian , Winter Bernd , Slavíček Petr
Published: June 2024

Liquid-jet photoemission spectroscopy directly probes specific molecular structure of solutes.
Excitation of long-lived nuclear spin order using spin-locking: a geometrical formalism
Authors: Mudgil Manjeet , Kurur Narayanan D.
Published: June 2024

LLS excitation during spin-locking in weakly coupled two-spin systems; explained through a geometrical formalism.
Computational design of transition metal catalysts for hydrodefluorination of trifluoromethylarenes using hydrosilane
Authors: Worakul Thanapat , Sawatlon Boodsarin , Surawatanawong Panida
Published: June 2024

To describe the catalytic activity of hydrodefluorination by nickel complexes using molecular volcano plots, multiple reference states must be considered.
One step synthesis of nitrogen-rich green primary explosives from secondary explosives: synthesis, characterization, and performance study
Authors: Kumar Parasar , Ghule Vikas D. , Dharavath Srinivas
Published: June 2024

Mono and di-azido group substituted TNBI-based metal free green primary explosives were synthesised. Newly made molecules show better detonation performance (7593–8494 m s−1; 21.3–30.0 GPa) than commonly used primary explosives – DDNP and Pb(N3)2.
Design of PDMS/PAN composite membranes with ultra-interfacial stability via layer integration
Authors: Sang Chao , Zhang Siyuan , Si Zhihao , Li Qinxu , Wu Hanzhu , Wang Lankun , Dong Shilong , Baeyens Jan , Cao Peng-Fei , Qin Peiyong
Published: June 2024

Ultra-interfacial stable composite membranes based on a facile photo-triggered co-grafting PDMS layer achieve superior separation performance and prolonged lifetimes.
Near-infrared aggregation-induced emission characteristics of new o-carborane fluorophores with large stokes shifts and self-recovering mechanochromic luminescence
Authors: Wu Xueyan , Li Na , Zhang Chenxi , Lv Yan , Guo Jixi
Published: June 2024

o-Carborane fluorophores with large Stokes shifts (>14 000 cm−1) near-infrared AIE characteristics and self-recovering mechanochromic luminescence.
Synthesis, investigation of the crystal structure, DFT calculations, and in silico medicinal potential of hydrazono- and aminomethylene substituted pyrazolidine-3,5-diones as potential anticancer scaffolds
Authors: El Bakri Youness , Siddique Sabir Ali , Mohamed Shaaban K. , Sarfraz Muhammad , Abuelizz Hatem A. , Al-Salahi Rashad , Mague Joel T. , Ahmed Eman A.
Published: June 2024

Two new pyrazolidine-3,5-dione derivatives were synthesized and their structures were elucidated by single-crystal X-ray analysis. The molecules were screened for their medicinal potential based on physiochemical and pharmacokinetics.
An in situ spectroscopic study of 2D CuS/Ti3C2 photocatalytic CO2 reduction to C1 and C2
Authors: Li Wanhe , Chen Yahui , Jia Shuhan , Zhou Yiying , Hua Yiting , Lin Xinyu , Zhu Zhi
Published: June 2024

The construction of heterojunctions is an effective strategy to improve the photogenerated carrier mobility rate and enhance the photocatalytic performance.
The highly selective green colorimetric detection of yttrium ions in biological and environmental samples using the synergistic effect in an optical sensor
Authors: Aljabri Mahmood D. , El-Bahy Salah M. , El-Sayed Refat , Debbabi Khaled F. , Amin Alaa S.
Published: June 2024

Schematic representation for the preparation and complexation of Y3+ ions on the formed optical sensor. The images are real photos of the sensor.
Sustainable strategies to achieve industrial ethanol titers from different bioenergy feedstocks: scale-up approach for better ethanol yield
Authors: Deshavath Narendra Naik , Woodruff William , Singh Vijay
Published: June 2024

Hydrothermal pretreatment is a promising approach to lignocellulosic biomass processing for enzymatic hydrolysis and high-yield bioethanol fermentation, as it reduces downstream inhibitor content and the amount of toxic byproducts generated.
Ni-rich layered cathodes in sodium-ion batteries: perspectives or déjà vu?
Authors: Gonçalves Josué M. , Silva Gustavo T. M. , Zanin Hudson
Published: June 2024

This Highlight explores advancements in Ni-rich cathode materials for sodium-ion batteries, which offer practical synthesis methods, high specific capacity, and environmental benefits while addressing energy density and cycle life challenges.
A nickel silicate MFI-type zeolite catalyst prepared by interzeolite transformation: tailoring the catalytic active sites for glucose conversion
Authors: Kweon Sungjoon , Cho Yunhye , Park Jun Seong , Ryu Jiae , Yoo Chang Geun , Min Hyung-Ki , Park Min Bum
Published: June 2024

Lewis–Brønsted Ni-MFI was tailored using the distinct kinetics of structural transformation and framework Ni stabilization in interzeolite transformation, catalyzing glucose conversion.
Synchronous monitoring of underwater dynamic/static pressure based on piezoelectric/capacitive polyester elastomer/carbon nanotube composites
Authors: Tang Yuxing , Dang Qing , Zhang Wei , Guo Haiquan , Pan Hong , Xiang Yong , Liao Bin , Hu Xiaoran
Published: June 2024

The pressure sensors provide significant information for monitoring underwater environments.
A [V6B20]-based architecture incorporating two types of organic amine ligands: innovative additives for enhancing the proton conductivity of Nafion membrane
Authors: Liu Xinxin , Ma Linyushan , Zhou Lijing , Guo Biao , Zhao Zhen
Published: June 2024

The novel composite material VB-1/Nafion demonstrates a remarkable enhancement in proton conductivity when compared to pure Nafion.
The threat of zero‐dynamics attack on non‐linear cyber‐physical systems
Authors: Norouzi Mobarakeh Amir , Ataei Mohammad , Hooshmand Rahmat‐Allah
Published: June 2024

Zero‐dynamics attack (ZDA) is a destructive stealthy cyberattack that threatens cyber‐physical systems (CPS). The authors have warned about the risk of a cyberattack by introducing a new general ZDA that can be effective and robust in non‐linear multiple‐input multiple‐output CPS. In this proposed attack policy, the adversary extracts the sensor and actuator online data on the network platform. Then, by utilising a state observer and considering specific delay times, the attacker injects a ZDA signal into the actuator channels of the cyber‐physical system. As a result, the internal dynamics will diverge from the nominal working region of the controlled cyber‐physical system, while the outputs remain close to the actual outputs of the attack‐free system. Therefore, this cyberattack can remain stealthy, and it can also be robust against revealing signals. The efficiency of this new attack policy is demonstrated in the simulation results for a continuous stirred tank reactor regarded as a cyber‐physical system.
Optimal bidding strategy for generation companies alliance in electricity‐carbon‐green certificate markets
Authors: Lu Zhilin , Zhan Bochun , Li Zihao , Leng Yuan , Yang Xinhe , Wen Fushuan
Published: June 2024

To promote the profit of generation companies and reduce carbon emissions from the generation sector, a two‐layer decision‐making model based on the cooperative game is proposed. Based on the analysis of a renewable‐fossil energy generation alliance to participate in electricity‐carbon‐green certificate markets, a robust optimization model considering the price uncertainty in the electricity spot market is first established based on the information gap decision‐making theory as the upper part of a two‐layer optimization model. Subsequently, the clearing models of the electricity spot, carbon emission trading, and green certificate markets are established. This two‐layer optimization model is transformed into a single‐layer model based on the well‐established KKT conditions. A profit allocation model for the members of the generation alliance is then presented based on the Shapley value and an improved nucleolus kernel method. Finally, the effectiveness of the proposed model is demonstrated by the IEEE 14‐bus power system.
Randomised orthogonal matching pursuit algorithm with its application in fast analysis of wide‐angle electromagnetic scattering problems based on compressive sensing
Authors: Qi Qi , Fan Yunuo , Cao Xinyuan , Liu Yi , Kong Meng , Huang Zhixiang , Wu Xianliang
Published: June 2024

The wide‐angle electromagnetic scattering problems can be rapidly solved by using the method of moments in conjunction with compressive sensing theory. The method mainly has two computational parts: measurement and recovery. To further enhance the performance, an improved orthogonal matching pursuit algorithm with a randomised atom selection process is proposed, significantly reducing the computational complexity of the recovery part. Additionally, a restart mechanism is designed to eliminate possible errors that might occur during the random process, ensuring the accuracy of recovery results. Numerical experiments with objects of different shapes validate the effectiveness and efficiency of the proposed scheme.
Deposition characteristics and growth mechanism of flue gas in the treatment of zinc-containing dust by rotary hearth furnace
Authors: Ma Shaobo , Zhang Zhaohui , Li Honghong , Guo Shenglan , Xing Xiangdong , Du Zhongze
Published: June 2024

The Rotary Hearth Furnace (RHF) process is an effective method for treating zinc-containing dust to recover valuable metals, but the significant deposition of flue gas during processing limits production efficiency. This study provides detailed insights into the mechanism of flue gas deposition in the treatment of zinc-containing dust in RHF through X-ray fluorescence spectrometer, X-ray diffraction, scanning electron microscopy, theoretical thermodynamic calculation and flue gas deposition experiments under high-temperature roasting. The results show that the deposits consist of ZnO, NaCl, KCl, K2SO4, Na2SO4, and ZnCl2. During the flue gas deposition process, ZnCl2 firstly precipitates and aggregates other deposited particles as a binding phase to form agglomerates. Under the driven by the thermophoresis of the flue gas, the agglomerates contact the heated surface, creating the initial deposition layer. The rough surface of this layer accelerates the deposition of chloride compounds from the flue gas. As the flue gas flows, the deposition layer continues to grow, leading to an increase in layer thickness and the eventual formation of periodic dense deposits.
Agent conversationnel et pragmatique gricéenne
Authors: Borderieux Julien
Published: June 2024

La contribution cherche à montrer l’influence de l’analyse conversationnelle (et notamment celle de la pensée linguistique de Grice, 1975) sur les choix rédactionnels observables dans les productions automatiques de textes argumentatifs par l’agent conversationnel ChatGPT. L’objectif intermédiaire consiste, dans un premier temps, à dégager le substrat de l’analyse conversationnelle anglo-saxonne à l’œuvre dans les réponses de cet agent de conversation, puis à établir les points de concordance entre les textes générés par un agent de conversation comme ChatGPT et les maximes conversationnelles de Grice. Dans un deuxième temps, il s’agira de montrer comment les productions de ce type d’agent conversationnel peuvent être considérées comme des objets gricéens (ces derniers seront dûment définis et on insistera sur l’intérêt de les observer, puisqu’ils contribuent notamment à la classification des textes). Nous ouvrirons à cette occasion le débat sur la notion d’implicature conversationnelle: est-elle ou non pleinement maîtrisée par un robot parleur comme ChatGPT ? Enfin, on proposera un prolongement sur la détection (basée sur l’utilisation systématique et routinière des maximes de Grice) des textes générés exclusivement par un agent conversationnel de ce type: il s’agira de poser la question du repérage des textes produits par des chatbots.
Ah oui d’accord okay : marqueurs discursifs et expression de l’alignement conversationnel
Authors: Crible Ludivine
Published: June 2024

Tout dialogue nécessite une certaine coordination afin d’assurer la réussite de la tâche: les représentations mentales des interlocuteurs doivent être négociées et converger progressivement au cours de l’interaction. Ce processus est appelé alignement conversationnel par Pickering et Garrod (2021). Parmi les outils disponibles pour exprimer l’alignement conversationnel, cet article se penche sur les marqueurs discursifs d’alignement (MDAs). Notre étude quantitative en dresse le portrait et la distribution dans des dialogues orientés-tâche. L’analyse a révélé que ces marqueurs prennent une place de plus en plus proéminente dans le dialogue à mesure que les représentations des interlocuteurs sont partagées et consolidées, acquérant ainsi un rôle structurel en plus de leur valeur interpersonnelle de base. Certains marqueurs tendent à se spécialiser dans une (ou deux) fonction particulière, et les locuteurs exploitent ces ressources en combinant parfois les formes et les fonctions dans d’impressionnants empilements de marqueurs. Certaines formes semblent assez spécifiques au dialogue orienté-tâche et moins prototypiques en tant que marqueurs discursifs, comme ça marche ou j’ai, mais elles remplissent les critères définitoires et ont la même valeur pragmatique que d’autres formes plus classiques comme OK.
Expression formulaire du désaccord dans les réunions de travail et les fils de discussion Wikipédia
Authors: Chandelier Marie , Tutin Agnès , Etienne Carole , Poudat Céline
Published: June 2024

Cette étude a pour objectif de comparer l’expression formulaire du désaccord dans deux types d’interaction: les réunions de travail et les fils de discussion Wikipédia. Nous explorons la façon dont les phrases préfabriquées des interactions (PPI) comme tu crois ? aucun rapport; ça marche pas expriment le désaccord de façon directe ou indirecte. L’analyse des PPI met en évidence des différences entre les patrons sémantiques et pragmatiques de l’oral et de l’écrit. Dans les discussions Wikipédia, les modes d’expression du désaccord sont plus diversifiés et ont une dimension conflictuelle plus marquée que dans les réunions. Le désaccord y est majoritairement énoncé de façon indirecte, à travers l’expression de la surprise, la formulation d’évaluations négatives visant l’allocutaire ou les propos qu’il a tenus. Dans les réunions en revanche, les PPI sont davantage modalisées, ménageant la face de l’interlocuteur.
L’être comme fautif. Actes de condamnation, altérité et rapport de places dans l’interaction parent-enfant
Authors: Moreau Raguenes Rose
Published: June 2024

Cet article s’intéresse aux actes de condamnation de l’être (Laforest & Moïse 2013) dans le contexte de l’interaction parent-enfant, adressés par le parent maltraitant à son enfant et rapportés par cette dernière ou ce dernier dans des témoignages anonymes publiés sur le compte Instagram francophone Parents toxiques. L’étude porte sur un échantillon de dix témoignages publiés entre mai 2020 et juillet 2021. L’objectif est, d’une part, de caractériser les modalités du traitement de l’altérité qui contribuent à une perception de l’interaction comme inappropriée ou maltraitante; d’autre part, d’interroger si le rapport d’autorité constitutif de l’interaction parent-enfant est perturbé dans et par les actes de condamnation de l’être, et si oui, comment. À cette fin, l’étude s’organise en trois temps: le premier volet explicite la méthodologie d’identification et d’analyse des actes de condamnation rapportés; le deuxième met en évidence les ressorts discursifs des actes de condamnation de l’être rapportés par les autrices et l’auteur des témoignages; le dernier volet s’attache à caractériser les motifs qui sous-tendent la construction de l’être comme fautif, et les implications de ceux-ci en termes de rapport de places. Les analyses menées montrent que la condamnation de l’être puise sa force pragmatique dans sa légitimation, construite en discours et interaction, par l’appui sur des normes présentées comme universelles et la mise en saillance du préjudice causé par l’autre. Construire l’être comme fautif consiste, à différents degrés, à essentialiser et rétrograder l’autre ainsi qu’à faire un amalgame entre sa valeur intrinsèque et sa valeur pour soi.
L’informaction pour l’environnement : analyse du site de « Bon Pote »
Authors: Sandré Marion
Published: June 2024

Cet article propose d’analyser l’hybridité générique du média indépendant de « Bon Pote »: depuis ses débuts en tant que blog jusqu’à la mise à jour récente du site d’information. Pour analyser le discours produit, à la rencontre de ces 2 genres, je m’intéresserai aux stratégies discursives et énonciatives utilisées par l’auteur pour construire et conjuguer information et action pour l’environnement. Dans la première partie -informer -je montre comment l’auteur allie argumentation et vulgarisation, en analysant notamment les procédés dialogiques utilisés. Dans la seconde partie promouvoir l’action -je m’intéresse à la relation que Bon Pote instaure avec ses lecteurs, en utilisant notamment les problématiques liées à l’énonciation, et aux conseils qu’il leur donne. Des conseils pour changer au quotidien mais aussi pour argumenter à leur tour en faveur de l’environnement. Cette étude montre les diffférents éthos que l’auteur construit de lui-même: ethos d’expert, de pédagogue et de citoyen engagé, mais aussi de son lecteur: de novice à écologiste convaincu prêt à agir et à argumenter à ses côtés. La conclusion permet d’analyser la relation interlocutoire développée, intimement liée à l’hybridité générique du corpus.
Transitivité et discours direct : une relation qui ne va pas de soi
Authors: Lacaze Grégoire
Published: June 2024

La transitivité à l’œuvre dans les langues indo-européennes a fait l’objet de nombreuses recherches menées par des linguistes inscrivant leurs travaux dans différentes approches théoriques. Dans le cas du discours rapporté, il s’agit de mettre au jour la nature des relations syntaxiques existant entre un segment contextualisant et un discours cité qui l’accompagne.

Il est indéniable que des verbes transitifs, le plus souvent des verbes de parole ou de communication, sont très souvent employés dans les segments introducteurs de discours direct. Par ailleurs, la présence abondante de verbes intransitifs ou de verbes transitifs indirects comme verbes introducteurs de discours direct, aussi bien dans des segments contextualisants en position initiale qu’en position incise, illustre le besoin de dépasser les limites d’un modèle dans lequel le discours cité occupe la position de complément d’objet direct d’un verbe introducteur.

Les recherches menées dans cette étude montrent que l’hypothèse de « transitivisation » du discours direct mérite d’être remise en cause. Les récents travaux de Frédéric Gachet (2015) et d’Aude Laferrière (2018) démontrent l’actualité de ces questionnements pour les incises de discours direct. La présente recherche envisage de réinterroger la notion de transitivité dans une approche énonciativiste mettant en perspective des phénomènes linguistiques à partir d’observables provenant d’un large corpus d’articles de presse du quotidien français Le Monde.
Violences verbales dans les discours socionumériques au sujet des relations internationales en crise structurelle
Authors: Ukhova Polina
Published: June 2024

Nous vivons aujourd’hui une nouvelle ère des relations internationales. Elle pourraît être cristalisée en termes de « désoccidentalisation ». Les événements qui marquent l’actualité mondiale sont nombreux et bouleversants. Ils sont au centre de nos échanges numériques quotidiens. Dans cet article, nous souhaiterions nous focaliser sur ces interactions ordinaires socionumériques afin de démontrer que la réalité des RI destabilisées devient particulièrement propice à la production de discours violents se construisant à travers la mise en œuvre d’actes menaçants directs et indirects et de distinguer les moteurs et les constituants de ces derniers. Nous le ferons en décomposant les séquences de notre corpus en éléments de différents niveaux
« Petit malaise » ou « très gros souci » ? Atténuation et intensification dans les descriptions profanes d’urgences vitales au téléphone
Authors: Giraudier Emma , Riou Marine
Published: June 2024

Avec une méthodologie s’inscrivant dans le cadre de la linguistique interactionnelle, cette étude porte sur un corpus d’appels d’urgence en français pour des urgences médicales. Nous analysons le degré de gravité exprimé par des appelants profanes par le biais de leur emploi de marqueurs d’intensité, tels que les adverbes de degré. Nous proposons une analyse structurale et interactionnelle des marqueurs déployés à des fins d’intensification ou d’atténuation dans les descriptions de l’état du patient. Pour ce faire, nous documentons les structures grammaticales employées et la façon dont les régulateurs y répondent et réagissent dans les tours de parole suivants. Nous proposons que cette étude des structures grammaticales employées par les appelants profanes pour des urgences avérées est une fenêtre privilégiée pour mieux comprendre les liens entre urgence ressentie, urgence exprimée, et urgence réelle.
Cartographie micro-diachronique de la variation phonologique du français en Suisse romande (1970-2020)
Authors: Avanzi Mathieu
Published: June 2024

Le but de ce article est double : il s’agira d’une part de présenter les résultats d’une enquête destinée à évaluer la vivacité de certaines oppositions phonologiques qui touchent au systèmes des voyelles à l’intérieur d’une région bien délimitée dans la francophonie, la Suisse ; d’autre part de mettre en rapport les résultats de cette enquête avec les résultats d’études conduites à la fin des années 70 (Métral 1977), et ainsi de juger de l’évolution du système, à près d’un demi-siècle d’intervalle.