bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Medications and the Roles of Pharmacists on the Recovery of Patients with COVID-19 Infection: An Epidemiological Study from the United Arab Emirates
Authors: Basheti Iman A. , Barqawi Hiba , Nassar Razan I. , Thiab Samar , Atatreh Noor , Abu-Gharbieh Eman
Published: February 2023

Patients infected with coronavirus have new experiences and hence new needs from the healthcare sector. Acknowledging patients’ experiences can exhibit promising outcomes in coronavirus management. Pharmacists are considered a vital pillar in managing patients’ experiences during their infection. A cross-sectional study was conducted to assess the experiences of COVID-19-infected individuals and the roles of pharmacists in the United Arab Emirates. The survey was face- and content-validated after being developed. Three sections were included in the survey (demographics, experiences of infected individuals, and the roles of pharmacists). Data were analyzed using the Statistical Package for the Social Sciences. The study participants (n = 509) had a mean age of 34.50 (SD = 11.93). The most reported symptoms among participants were fatigue (81.5%), fever (76.8%), headache (76.6%), dry cough (74.1%), muscle or joint pain (70.7%), and sore throat (68.6%). Vitamin C was the most used supplement (88.6%), followed by pain relievers (78.2%). Female gender was the only factor associated with symptom severity. About 79.0% agreed that the pharmacist played an important and effective role during their infection. The most reported symptom was fatigue, with females reporting more severe symptoms. The role of the pharmacist proved to be vital during this pandemic.
Development and Validation of a Risk-Prediction Nomogram for Chronic Low Back Pain Using a National Health Examination Survey: A Cross-Sectional Study
Authors: Kim Jung Guel , Park Sang-Min , Kim Ho-Joong , Yeom Jin S.
Published: February 2023

Background: Several prognostic factors have been reported for chronic low back pain (CLBP). However, there are no studies on the prediction of CLBP development in the general population using a risk prediction model. This cross-sectional study aimed to develop and validate a risk prediction model for CLBP development in the general population, and to create a nomogram that can help a person at risk of developing CLBP to receive appropriate counseling on risk modification. Methods: Data on CLBP development, demographics, socioeconomic history, and comorbid health conditions of the participants were obtained through a nationally representative health examination and survey from 2007 to 2009. Prediction models for CLBP development were derived from a health survey on a random sample of 80% of the data and validated in the remaining 20%. After developing the risk prediction model for CLBP, the model was incorporated into a nomogram. Results: Data for 17,038 participants were analyzed, including 2693 with CLBP and 14,345 without CLBP. The selected risk factors included age, sex, occupation, education level, mid-intensity physical activity, depressive symptoms, and comorbidities. This model had good predictive performance in the validation dataset (concordance statistic = 0.7569, Hosmer–Lemeshow chi-square statistic = 12.10, p = 0.278). Based on our model, the findings indicated no significant differences between the observed and predicted probabilities. Conclusions: The risk prediction model presented by a nomogram, which is a score-based prediction system, can be incorporated into the clinical setting. Thus, our prediction model can help individuals at risk of developing CLBP to receive appropriate counseling on risk modification from primary physicians.
Change Detection between Retrospective and Contemporary 3D Models of the Omega House at the Athenian Agora
Authors: Panagiotopoulou Antigoni , Wallace Colin Allan Bruce , Ragia Lemonia , Moullou Dorina
Published: February 2023

Archaeological monuments all over the world face problems of conservation and maintenance due to natural events and processes as well as human intervention, all of which lead to their alteration and deterioration. In particular, monuments and sites that have been excavated and left exposed to the elements experience decay, which would have taken centuries prior to excavation, in just a few years when left unprotected. Thus, the necessity to detect and observe changes over time becomes paramount. Legacy data and, in particular, retrospective photogrammetric modeling, are vital tools in this process. In this work we compare two photogrammetric 3D models of the Omega House, in the Athenian Agora, to assess how much the site has changed between the time of its first excavation in 1972 and its current state. Constructive Solid Geometry (CSG) is utilized to perform Boolean operations. Additionally, distance and volume calculations are performed. The software CloudCompare was used for this work. Overall, the state of Omega House monument proves to have been preserved from 1972 to 2017, except for certain differences that are highlighted as follows: The central north part of the monument in the model 2017 presents increased volume per 7.86% in comparison with the model 1972. The northeast part of the monument in the 2017 model shows decreased volume per 5.11% when compared to the model 1972. Moreover, the calculated distances between the two models from 1972 and 2017 present the greatest values in the case of the southwest and northwest parts of the monument, ranging between −17 cm to 5 cm.
The “San Giacomo di Galizia” Warship Galleon (1597)—Building Narratives through an Archaeological and Historical Reading of the Ribadeo I Shipwreck
Authors: Casimiro Tânia Manuel , Martínez-Ramirez Sagrario , Crespo-Solana Ana , San Claudio Santa Cruz Miguel , Castro Inês Almendra
Published: February 2023

Early November 1597. After an intense combat with four enemy ships, San Giacomo di Galizia (also known as Santiago), a just over 1000-ton galleon, enters the Ribadeo harbour in a terrible state, where it wrecks. This war vessel had been built in Naples in 1590 and sailed the Mediterranean and the Atlantic until it sank. In late November 2011, during an archaeological survey of the dredge area to improve the navigation of the ports in Galicia, a large ship was found and identified as the San Giacomo, which wrecked 414 years prior to its discovery. Several archaeological campaigns permitted a thorough record of the wreck and the recovery of hundreds of objects which this ship carried on its final journey. These artefacts included ceramics, metalwork, and wood, objects which reflected the activities that occurred on board during its short life. Combining an interdisciplinary approach based on artefacts, documents, and chemical analysis, the aim of this paper is to, on the one hand, attempt to reconstruct the sailing itinerary of the ship over its period of use and, on the other, to discuss how these commodities can help to write new narratives about the activities which occurred on board.
New Varieties of the Common Cyclamen (Cyclamen purpurascens Mill.) in Slovenia
Authors: Bavcon Jože , Ravnjak Blanka
Published: February 2023

Common cyclamen (Cyclamen purpurascens Mill.) is the only representative of its genus in Slovenia where it is a widespread species, growing from sea level to high mountainous areas. It thrives in all four major phytogeographic regions: Alpine, Dinaric, sub-Pannonian and sub-Mediterranean, in both transitional regions, pre-Alpine and pre-Dinaric, and it reacts quickly to weather conditions. It is found mostly in deciduous and mixed forests, at forest margins and in mountain meadows. In the highlands, it often grows on gravel and can also be found in fairly low-scree areas. As such, it is expected to shows great intraspecific diversity. Based on a collection of 6000 units of C. purpurascens specimens collected in different parts of Slovenia, we were able to determine different types of C. purpurascens and describe new varieties. All of the specimens were divided into four groups with respect to leaf pattern, which is the most durable distinguishing feature. The four dividing groups were silvery, semi-silvery, marbled and green. The most notable variety in the silvery group was C. purpurascens ‘Idrija’, while in the semi-silvery group, it was C. purpurascens ‘Nova Gorica’, in the marbled group, it was ‘C. purpurascens ‘Slivje’ and in the green group, it was C. purpurascens ‘Podsreda’.
Effects of Seed Priming and Foliar Treatment with Ascorbate, Cysteine, and Triacontanol on Canola (Brassica napus L.) under Field Conditions
Authors: Molnár Katalin , Biró-Janka Béla , Domokos Erzsébet , Nyárádi Imre-István , Fodorpataki László , Stoie Andrei , Duda Matei Marcel
Published: February 2023

Studies conducted in controlled environments showed that seed priming and foliar treatments with various bioactive substances can stimulate germination, uniform seedling emergence, photosynthesis, and nutrient uptake efficiency and can lead to increased productivity, crop stand, and quality. Only a few studies provide a comparative experimental outlook about the use of the bioactive substances in open-field cultivated canola. The aim of this study was to investigate the effects of seed priming and foliar treatment with ascorbate (AsA), cysteine (Cys), and triacontanol (Tria) on the growth and yield parameters of two canola cultivars rapeseed cultivars (“Factor” and “Hybrirock”) under open-field conditions for three growing seasons under temperate conditions from Central Transylvania. Plant growth and yield parameters were recorded at different plant development stages: in autumn (early vegetative period), in spring, and at harvest. Not all substances that have undergone laboratory testing were successful in the field. Seed priming with 10 ppm Cys and AsA had beneficial effects on the development of seedlings, whereas their foliar application enhanced the number of silique, seed yield, and the oil content of the studied canola cultivars. The effects of Tria were visible on the biometrics parameters only in autumn and spring, and also on the root parameters, but in some cases, 10 ppm Tria had no effect on plants, or even a negative effect could be observed on important parameters for agriculture such as estimated seed yield, seed yield/plant, and oil content. Optimizing treatment and application by determination of the lowest effective concentration, together with the frequency of treatments and persistence effects are crucial for cost-effectiveness.
Assessment of Genetic Variability for Fruit Nutritional Composition in the Ex-Situ Collection of Jujube (Ziziphus spp.) Genotypes of Arid Regions of India
Authors: Meena Vijay Singh , Singh Kartar , Shekhawat Neelam , Bhardwaj Rakesh , Lal Hanuman , Rani Kirti , Gupta Veena , Kumar Ashok , Singh Akath , Gora Jagan Singh , Kumar Pradeep
Published: February 2023

Jujube or ber (Ziziphus spp.) is one of the most important fruit crops of India’s arid and semi-arid regions because of its high adaptability to resource constraints hot (semi)arid region. Jujube is a rich source of minerals, vitamins and dietary antioxidants to arid zone dwellers, where it is known as poor man’s apple. Given the present rising trends in discovering and exploiting plant-based health-promoting compounds, it is imperative to know the extent of variability with respect to fruit nutritional compositions present in the jujube germplasms. In this study, we assessed genetic variability for fruit nutritional and functional quality traits in eighteen jujube accessions belonging to three species (Z. mauritiana, Z. rotundifolia and Z. oenoplia) from an ex-situ collection from Indian arid and semi-arid regions in two consecutive fruiting seasons (2020-21 and 2021-22). Results revealed significant variability among eighteen jujube genotypes for important fruits physico-biochemical parameters. The IC 625864 (Z. oenoplia) identified as a superior accession for fruit antioxidant potential with having high levels of total phenols (256.2 mg/100 g dry weight) and total antioxidants (423 mg/100 g in FRAP). Moreover, IC 625849 (Z. mauritiana) and IC 625848 (Z. rotundifolia) were other genotypes containing high levels of phenols and total antioxidant (FRAP). Thus, while aiming for simultaneous improvement for total antioxidants with phenols, IC 625848, IC 625849 and IC 625864 genotypes can be considered as valuable resource for jujube fruit quality improvement program. Further, the high levels of phenotypic variance with high genotypic variance coupled with high heritability and genetic advance particularly for total antioxidants, total phenols, and ascorbic acid contents in fruits, indicating them to be considered as reliable biochemical markers to identify the productive genotypes having higher amounts of dietary antioxidants. Depending on the identified genotypes for their richness in the particular phytonutrients, these can be exploited either for table purpose or biofortification of other products, or using in jujube breeding program for quality improvement.
Revisiting of a Three-Parameter One-Dimensional Vertical Infiltration Equation
Authors: Kargas George , Koka Dimitrios , Londra Paraskevi A.
Published: February 2023

In the present study, the three-parameter one-dimensional vertical infiltration equation recently proposed by Poulovassilis and Argyrokastritis is examined. The equation includes the saturated hydraulic conductivity (Ks), soil sorptivity (S), and an additional parameter c; it is valid for all infiltration times. The c parameter is a fitting parameter that depends on the type of porous medium. The equation is characterized by the incorporation of the exact contribution of the pressure head gradient to flow during the vertical infiltration process. The application of the equation in eight porous media showed that it approaches to the known two-parameter Green–Ampt infiltration equation for parameter c = 0.300, while it approaches to the two-parameter infiltration equation of Talsma–Parlange for c = 0.750, which are the two extreme limits of the cumulative infiltration of soils. The c parameter value of 0.500 can be representative of the infiltration behavior of many soils for non-ponded conditions, and consequently, the equation can be converted into a two-parameter one. The determination of Ks, S, and c using one-dimensional vertical infiltration data from eight soils was also investigated with the help of the Excel Solver application. The results showed that when all three parameters are considered as adjustment parameters, accurate predictions of S and Ks are not achieved, while if the parameter c is fixed at 0.500, the prediction of S and Ks is very satisfactory. Specifically, in the first case, the maximum relative error values were 33.29% and 39.53% for S and Ks, respectively, while for the second case, the corresponding values were 13.25% and 17.42%.
Te Maramataka—An Indigenous System of Attuning with the Environment, and Its Role in Modern Health and Well-Being
Authors: Warbrick Isaac , Makiha Rereata , Heke Deborah , Hikuroa Daniel , Awatere Shaun , Smith Valance
Published: February 2023

The connection between the natural environment and human health is well documented in Indigenous narratives. The maramataka—a Māori system of observing the relationships between signs, rhythms, and cycles in the environment—is underpinned by generations of Indigenous knowledge, observation, and experimentation. The maramataka enabled Māori and our Pacific relatives to attune with the movements of the environment and ensure activities essential for survival and well-being were conducted at the optimal times. A recent revival of the maramataka in various communities in New Zealand is providing uniquely Indigenous ways to ‘reconnect’ people, and their health, with the natural environment. In a world where people have become increasingly disconnected from the natural environment, the maramataka offers an alternative to dominant perspectives of health. It also provides a mechanism to enhance the many facets of health through an understanding of the human–ecosystem relationship in a uniquely Indigenous way. This conceptual paper (i) highlights a uniquely Indigenous way of understanding the environment (the maramataka) and its connection to health, (ii) discusses the connections between the maramataka and scientific research on health and the environment, and (iii) introduces current and potential applications of the maramataka in improving health and well-being.
Evaluation of the Impact of a Tourniquet Training Program: A Cross-Sectional Study
Authors: González-Alonso Valentín , Usero-Pérez María del Carmen , Seguido Chacón Raquel , Gómez de la Fuente Alicia , Cortés-Martín Jonathan , Rodríguez-Blanque Raquel , Sánchez-García Juan Carlos
Published: February 2023

Among the main preventable causes of death in the area of operations is external exsanguinating hemorrhage in the extremities, hence the importance of the tourniquet as a therapeutic tool in this type of injury and, therefore, of the training of personnel participating in international missions. The main objective of this study is to determine the impact of training in the application of this device. This is a quasi-experimental, prospective, cross-sectional study, carried out with 97 healthy volunteers, military personnel who perform their work in the Royal Guard barracks of El Pardo. The study was conducted between June 2019 and July 2021. The correct determination of the device placement site and the times of correct device placement were evaluated by determining whether there was blood flow using Doppler ultrasound measurements. Statistically significant results were obtained for application time (76.68 s to 58.06 s; p < 0.001), correct device placement (p < 0.001), and achievement of complete ischemia in the upper extremity (23.7% pretest vs. 24.7% post-test; p < 0.001). In the lower extremity, after training, longer application duration (43.33 s to 47.30 s) and lower ischemia achievement (59.8% pretest vs. 37.8% post-test) were obtained. Standardized and regulated training improves device application. More intensive training is necessary to obtain better results.
Is It Time to Re-Shift the Research Agenda? A Scoping Review of Participation Rates in Workplace Health Promotion Programs
Authors: Bensa Katarina , Širok Klemen
Published: February 2023

Workplace health promotion programmes (WHPPs) are among the most important measures to improve the health and motivation of the ageing workforce. However, they are accompanied with certain challenges, such as low participation rates and higher participation levels of the more health-conscious workers, often failing to engage those who need such interventions the most. Following the PRISMA guidelines, this scoping review examined participation rates reported in articles on WHPPs to identify potential knowledge gaps. The results are worrying: participation rates are not only infrequently reported, but also low. Of the 58 articles, 37 report participation rates, with the majority (20) reporting an average participation rate of less than 50%. Reported participation rates refer either to different target groups, the type of intervention, or to single points in time, which makes it difficult to establish consistent criteria for comparison. We argue that despite the importance of WHPP efficacy, research focus should shift to the determinants of participation, as well as the issue of standardising the reporting of participation rates, alongside the potential problem of reporting bias.
Is the Verification Phase a Suitable Criterion for the Determination of Maximum Oxygen Uptake in Patients with Heart Failure and Reduced Ejection Fraction? A Validation Study
Authors: Manresa-Rocamora Agustín , Fuertes-Kenneally Laura , Blasco-Peris Carles , Sempere-Ruiz Noemí , Sarabia José Manuel , Climent-Paya Vicente
Published: February 2023

The verification phase (VP) has been proposed as an alternative to the traditional criteria used for the determination of the maximum oxygen uptake (VO2 max) in several populations. Nonetheless, its validity in patients with heart failure with reduced ejection fraction (HFrEF) remains unclear. Therefore, the aim of this study was to analyse whether the VP is a safe and suitable method to determine the VO2 max in patients with HFrEF. Adult male and female patients with HFrEF performed a ramp-incremental phase (IP), followed by a submaximal constant VP (i.e., 95% of the maximal workload during the IP) on a cycle ergometer. A 5-min active recovery period (i.e., 10 W) was performed between the two exercise phases. Group (i.e., median values) and individual comparisons were performed. VO2 max was confirmed when there was a difference of ≤ 3% in peak oxygen uptake (VO2 peak) values between the two exercise phases. Twenty-one patients (13 males) were finally included. There were no adverse events during the VP. Group comparisons showed no differences in the absolute and relative VO2 peak values between both exercise phases (p = 0.557 and p = 0.400, respectively). The results did not change when only male or female patients were included. In contrast, individual comparisons showed that the VO2 max was confirmed in 11 patients (52.4%) and not confirmed in 10 (47.6%). The submaximal VP is a safe and suitable method for the determination of the VO2 max in patients with HFrEF. In addition, an individual approach should be used because group comparisons could mask individual differences.
Influence of Foot Morphology on the Center of Pressure Pattern in Patients with Down Syndrome
Authors: Ferrario Cristina , Condoluci Claudia , Tarabini Marco , Manzia Carlotta Maria , Di Girolamo Gabriella , Pau Massimiliano , Galli Manuela
Published: February 2023

Background: The primary aim of this study was to assess how different conformations of the foot in individuals with Down syndrome affected the CoP during walking, and the secondary aim was to evaluate the effect of an excess of mass in young adults and children with Down syndrome and flat foot. The greater investigation of these aspects will allow for more targeted rehabilitation treatments to improve a patient’s quality of life. Methods: The tests were carried out on 217 subjects with Down syndrome, 65 children and 152 young adults, and on 30 healthy individuals, 19 children and 11 young adults. All subjects underwent gait analysis, and the group with Down syndrome was also assessed with baropodometric tests to evaluate foot morphology. Results: The statistical analysis showed that within both the young adult and child groups, the CoP pattern in the anterior–posterior direction reflected a difficulty in proceeding in the walking direction compensated by a medio–lateral swing. The gait of children with Down syndrome was more impaired than that of young adults. In both young adults and children, a higher severity of impairment was found in overweight and obese female individuals. Conclusions: These results suggest that the sensory deficits and the development of hypotonic muscles and lax ligaments of the syndrome lead to morphological alterations of the foot that, combined with the physical characteristics of short stature and obesity, negatively impact the CoP pattern of people with Down syndrome during walking.
Traumatic Childbirth Experience and Childbirth-Related Post-Traumatic Stress Disorder (PTSD): A Contemporary Overview
Authors: Kranenburg Leonieke , Lambregtse-van den Berg Mijke , Stramrood Claire
Published: February 2023

With this manuscript we provide an overview of the prevalence, symptoms, risk factors, screening, support, and treatment for women with a traumatic childbirth experience or childbirth-related PTSD. This overview is based on both recent literature and the authors’ clinical experiences from the fields of obstetrics, psychiatry and medical psychology to provide up-to-date knowledge about recognizing, preventing and treating CB-PTSD from a clinical perspective. We pay substantial attention to prevention as there are many things health care professionals can do or not do to contribute to a positive childbirth experience, and save women, their infants and families from a sub-optimal start due to childbirth-related trauma.
Change over Time in the Risk of Death among Japanese COVID-19 Cases Caused by the Omicron Variant Depending on Prevalence of Sublineages
Authors: Takahashi Yuki , Tanaka Hideo , Koga Yoshitaka , Takiguchi Shunichi , Ogimoto Shigeru , Inaba Shizuyo , Matsuoka Hiroyuki , Miyajima Yuka , Takagi Takeshi , Irie Fujiko , Bamba Yoshihito , Yoshimi Fuyo , Suzuki Tomoyuki , Araki Isao , Shirai Chika , Matsumoto Sayuri , Shimizu Motoyuki , Shibata Toshiyuki , Nagai Hitomi , Kinoshita Masaru , Fujita Rie , Ogata Tsuyoshi
Published: February 2023

To assess temporal changes to the risk of death in COVID-19 cases caused by the Omicron variant, we calculated age-standardized case fatality rates (CFR) in patients aged ≥40 years over nine diagnostic periods (3 January to 28 August 2022) in ten Japanese prefectures (14.8 million residents). Among 552,581 study subjects, we found that there were 1836 fatalities during the isolation period (up to 28 days from date of onset). The highest age-standardized CFR (0.85%, 95% confidence interval (CI):0.78–0.92) was observed in cases diagnosed in the second 4-week period (January 31 to February 27), after which it declined significantly up to the 6th 4-week period (0.23%, 95% CI: 0.13–0.33, May 23 to June 19). The CFR then increased again but remained at 0.39% in the eighth period (July 18 to August 28). The CFR in cases with the BA.2 or BA.5 sublineages in the age range 60–80 years was significantly lower than that with BA.1 infections (60 years: 0.19%, 0.02%, 0.053%, respectively; 70 years: 0.91%, 0.33%, 0.39%; ≥80 years: 3.78%, 1.96%, 1.81%, respectively). We conclude that the risk of death in Japanese COVID-19 patients infected with Omicron variants declined through February to mid-June 2022.
Effects of Temperatures and Heatwaves on Occupational Injuries in the Agricultural Sector in Italy
Authors: Di Blasi Chiara , Marinaccio Alessandro , Gariazzo Claudio , Taiano Luca , Bonafede Michela , Leva Antonio , Morabito Marco , Michelozzi Paola , de’ Donato Francesca K. ,   on behalf of the Worklimate Collaborative Group
Published: February 2023

The effects of heat on health have been well documented, while less is known about the effects among agricultural workers. Our aim is to estimate the effects and impacts of heat on occupational injuries in the agricultural sector in Italy. Occupational injuries in the agricultural sector from the Italian national workers’ compensation authority (INAIL) and daily mean air temperatures from Copernicus ERA5-land for a five-year period (2014–2018) were considered. Distributed lag non-linear models (DLNM) were used to estimate the relative risk and attributable injuries for increases in daily mean air temperatures between the 75th and 99th percentile and during heatwaves. Analyses were stratified by age, professional qualification, and severity of injury. A total of 150,422 agricultural injuries were considered and the overall relative risk of injury for exposure to high temperatures was 1.13 (95% CI: 1.08; 1.18). A higher risk was observed among younger workers (15–34 years) (1.23 95% CI: 1.14; 1.34) and occasional workers (1.25 95% CI: 1.03; 1.52). A total of 2050 heat-attributable injuries were estimated in the study period. Workers engaged in outdoor and labour-intensive activities in the agricultural sector are at greater risk of injury and these results can help target prevention actions for climate change adaptation.
Preparation and Coagulation Performance of Polyaluminum Lanthanum Silicate Coagulant
Authors: He Jie , Song Qixuan , He Jian
Published: February 2023

In order to address the growing problem of water pollution caused by the excessive discharge of contaminants and provide a better aquatic ecosystem for the public, increasing attention has been paid to the harmlessness and efficiency of coagulation. In this study, polyaluminum lanthanum silicate (PALS) was synthesized through co-polymerization as a novel coagulant to treat wastewater. FTIR, XRD, and SEM were used to analyze the morphology and structure of the material, which further confirmed that the PALS was successfully synthesized. The results indicated that PALS had a great performance in the treatment of a kaolin–humic acid suspension under the optimal synthesis conditions with Al/Si = 3, La/Si = 0.1, and basicity = 0.7. Compared with conventional coagulants, PALS exhibited a better performance at a low coagulant dose and could achieve a good removal effect for an ultraviolet wavelength less than 254 nm (UV254) (83.87%), residual turbidity (0.49 NTU), and dissolved organic carbon (DOC) (69.57%) at the optimal conditions. Additionally, the PALS showed a better effect on phosphate removal than other coagulants did, where the removal efficiency could reach 99.60%. Charge neutralization and adsorption bridging were the potential wastewater treatment mechanisms employed by the PALS, which showed varied contributions under different pH levels. The results indicated that PALS can be a promising coagulant in water treatment.
The Place of Botulinum Toxin in Spastic Hemiplegic Shoulder Pain after Stroke: A Scoping Review
Authors: Struyf Pieter , Triccas Lisa Tedesco , Schillebeeckx Fabienne , Struyf Filip
Published: February 2023

Stroke is a common pathology worldwide, with an age-standardized global rate of new strokes of 150.5 per 100,000 population in 2017. Stroke causes upper motor neuron impairment leading to a spectrum of muscle weakness around the shoulder joint, changes in muscle tone, and subsequent soft tissue changes. Hemiplegic shoulder pain (HSP) is the most common pain condition in stroke patients and one of the four most common medical complications after stroke. The importance of the appropriate positioning and handling of the hemiplegic shoulder for prevention of HSP is therefore of high clinical relevance. Nevertheless, HSP remains a frequent and disabling problem after stroke, with a 1-year prevalence rate up to 39%. Furthermore, the severity of the motor impairment is one of the most important identified risk factors for HSP in literature. Spasticity is one of these motor impairments that is likely to be modifiable. After ruling out or treating other shoulder pathologies, spasticity must be assessed and treated because it could lead to a cascade of unwanted complications, including spastic HSP. In clinical practice, Botulinum toxin A (BTA) is regarded as the first-choice treatment of focal spasticity in the upper limb, as it gives the opportunity to target specifically selected muscles. It thereby provides the possibility of a unique patient tailored focal and reversible treatment for post stroke spasticity. This scoping review aims to summarize the current evidence of BTA treatment for spastic HSP. First, the clinical manifestation and outcome measures of spastic HSP will be addressed, and second the current evidence of BTA treatment of spastic HSP will be reviewed. We also go in-depth into the elements of BTA application that may optimize the therapeutic effect of BTA. Finally, future considerations for the use of BTA for spastic HSP in clinical practice and research settings will be discussed.
Hygiene Practices and Early Childhood Development in the East Asia-Pacific Region: A Cross-Sectional Analysis
Authors: Petermann-Rocha Fanny , Rao Nirmala , Bala Manya , Parshad-Asnani Monika , Sifuna Anthony , Yousafzai Aisha , Ho Frederick K. , Ip Patrick
Published: February 2023

Poor hygiene might be a risk factor for early childhood development (ECD). This study investigated the associations of three hygiene practices (‘wash hands before a meal,’ ‘wash hands after going to the toilet,’ and ‘brush teeth’), separately and combined, with ECD. Six thousand six hundred ninety-seven children (4 [0.8] years) from the East Asia-Pacific Early Child Development Scales validation study were included in this cross-sectional analysis. The hygiene variables were recoded to have comparable values as ‘always,’ ‘sometimes,’ and ‘never.’ These variables were then grouped to create combined categories. The binary outcome variables, poor ECD, were defined as a score < age-specific 25th centile. Modified Poisson regression models were used to analyse the associations. Data collection was performed between 2012 and 2014, and the analyses were conducted in April 2022. Compared with children who ‘always’ washed their hands before a meal, those who did it ‘sometimes’ (Prevalence Ratio [PR]: 1.30 [95% CI: 1.16–1.46]) or ‘never’ (PR: 1.35 [1.18–1.55]) had a higher likelihood of poorer overall development. Comparable results were identified for the other two hygiene practices and the other four domain-specific outcomes (p < 0.05). Compared with children who always followed the three hygiene practices, the likelihood of poor overall ECD increased as the combined hygiene practice decreased among children with poor hygiene practices (PRnever: 1.67 [1.40–2.00]; PRrarely: 1.49 [1.30–1.71]; PRsometimes: 1.30 [1.14–1.49]). Children who did not always follow good hygiene practices had a higher likelihood of poor ECD independently of sociodemographic factors. Considering these findings, future hygiene practice interventions and trials should consider including ECD outcomes.
Effectiveness of a Single Prolonged Aerobic Exercise Session on Executive Function Task Performance in Physically Active Adults (21–70 Years of Age)
Authors: Yates Brandon A. , Armstrong Lawrence E. , Lee Elaine C. , Unverzagt Frederick W. , Dadzie Ekow , Lopez Virgilio , Williamson Keith , Vingren Jakob L. , Orkaby Ariela R.
Published: February 2023

We sought to examine the effectiveness of an acute prolonged exercise session on post-exercise executive function in physically active adults and to assess if age or pre-exercise cognitive performance was predictive of the magnitude of change in executive task performance. Self-registered cyclists were recruited prior to participating in a 161-km mass-participation cycling event. Cyclists were excluded if they had not previously participated in a similar endurance event, were young (<18 y), or were cognitively impaired (Mini CogTM < 3 units). Immediately after completing the exercise session, the time taken to complete Trail Making Test Part A and Part B (TMT A + B) was assessed. A faster time to complete the TMT A + B was observed after exercise (+8.5%; p = 0.0003; n = 62; age range = 21–70 y). The magnitude of change in TMT A + B performance (pre vs. post) was influenced by pre-exercise TMT A + B performance (r2 = 0.23, p < 0.0001), not age (r2 =0.002; p = 0.75). Prolonged exercise had a small-to-moderate effect on post-exercise compared to pre-exercise executive function task performance (Cohen’s d = 0.38–0.49). These results support the effectiveness of a single prolonged exercise bout to augment executive function in physically active adults, irrespective of age.
Influence of COVID-19-Related Interventions on the Number of Inpatients with Acute Viral Respiratory Infections: Using Interrupted Time Series Analysis
Authors: Noh Jin-Won , Lee Woo-Ri , Kim Li-Hyun , Cheon Jooyoung , Kwon Young Dae , Yoo Ki-Bong
Published: February 2023

After the first COVID-19 patient was diagnosed, non-pharmaceutical interventions such as social distancing and behavior change campaigns were implemented in South Korea. The social distancing policy restricted unnecessary gatherings and activities to prevent local transmission. This study aims to evaluate the effect of social distancing, a strategy for COVID-19 prevention, on the number of acute respiratory infection inpatients. This study used the number of hospitalized patients with acute respiratory infection from the Infectious Disease Portal of the Korea Centers for Disease Control and Prevention (KCDC) between the first week of January 2018, to the last week of January 2021. Intervention 1t represents the first patient occurrence of COVID-19, Intervention 2t represents the relaxing of the social distancing policy. We used acute respiratory infection statistics from Korea and segmented regression analysis was used. The analysis showed that the trend of the number of acute respiratory infection inpatients decreased after the implementation of the first patient incidence of COVID-19 due to prevention activities. After the relaxing of the social distancing policy, the number of inpatients with acute respiratory infections significantly increased. This study verified the effect of social distancing on the reduction in hospital admissions for acute respiratory viral infections.
Assessment of Excess Mortality in Italy in 2020–2021 as a Function of Selected Macro-Factors
Authors: Ceccarelli Emiliano , Minelli Giada , Egidi Viviana , Jona Lasinio Giovanna
Published: February 2023

Background: Excess mortality (EM) can reliably capture the impact of a pandemic, this study aims at assessing the numerous factors associated with EM during the COVID-19 pandemic in Italy. Methods: Mortality records (ISTAT 2015–2021) aggregated in the 610 Italian Labour Market Areas (LMAs) were used to obtain the EM P-scores to associate EM with socioeconomic variables. A two-step analysis was implemented: (1) Functional representation of EM and clustering. (2) Distinct functional regression by cluster. Results: The LMAs are divided into four clusters: 1 low EM; 2 moderate EM; 3 high EM; and 4 high EM-first wave. Low-Income showed a negative association with EM clusters 1 and 4. Population density and percentage of over 70 did not seem to affect EM significantly. Bed availability positively associates with EM during the first wave. The employment rate positively associates with EM during the first two waves, becoming negatively associated when the vaccination campaign began. Conclusions: The clustering shows diverse behaviours by geography and time, the impact of socioeconomic characteristics, and local governments and health services’ responses. The LMAs allow to draw a clear picture of local characteristics associated with the spread of the virus. The employment rate trend confirmed that essential workers were at risk, especially during the first wave.
Contextual Factors Associated with Abuse of Home-Dwelling Persons with Dementia: A Cross-Sectional Exploratory Study of Informal Caregivers
Authors: Steinsheim Gunn , Malmedal Wenche , Follestad Turid , Olsen Bonnie , Saga Susan
Published: February 2023

One in six community-dwelling older adults experience elder abuse yearly, and persons with dementia are especially at risk. Although many risk factors for elder abuse have been identified, there are still knowledge gaps concerning risk and protective factors. This cross-sectional survey among Norwegian informal caregivers (ICGs) aimed to find individual, relational, and community factors associated with psychological and physical abuse of home-dwelling persons with dementia. This study involved 540 ICGs and was conducted from May to December 2021. Statistical analysis using penalized logistic regression with lasso was performed to find covariates associated with psychological and physical elder abuse. The most prominent risk factor for both subtypes of abuse was the caregiver being a spouse. In addition, risk factors for psychological abuse were having a higher caregiver burden, experiencing psychological aggression from the person with dementia, and the person with dementia being followed up by their general practitioner. For physical abuse, the protective factors were the ICG being female and having an assigned personal municipal health service contact, while the risk factors were the ICG attending a caregiver training program and experiencing physical aggression from the person with dementia and the person with dementia having a higher degree of disability. These findings add to the existing knowledge of risk and protective factors in elder abuse among home-dwelling persons with dementia. This study provides relevant knowledge for healthcare personnel working with persons with dementia and their caregivers and for the development of interventions to prevent elder abuse.
PEEP-ZEEP Compared with Bag Squeezing and Chest Compression in Mechanically Ventilated Cardiac Patients: Randomized Crossover Clinical Trial
Authors: de Oliveira Taís Flores , Peringer Vinicius Serra , Forgiarini Junior Luiz Alberto , Eibel Bruna
Published: February 2023

Background and Objectives: Perform the bag squeezing and PEEP-ZEEP techniques associated with manual chest compression in mechanically ventilated cardiac patients in order to observe their effectiveness in the removal of pulmonary secretions and safety from a hemodynamic and ventilatory point of view. Methods: This is a randomized crossover clinical trial developed in a hospital in southern Brazil. We included hemodynamically stable male and female patients aged over 18 years who used invasive mechanical ventilation for at least 48 h. The control group was established for the bag-squeezing technique and the intervention group for the PEEP-ZEEP maneuver, both associated with manual chest compression. Tracheal aspiration was performed 2 h before in order to match the groups in relation to the volume of secretion, and also immediately at the end of the techniques in order to measure the amount of secretion collected. Results: The sample had 36 individuals with a mean age of 70.3 years, 21% of the patients were male, and the majority (10.4%) were hospitalized for ischemic heart disease. DBP (p = 0.024), MAP (p = 0.004) and RR (p = 0.041) showed a significant difference in the post-moment in both groups. There was a significant difference in the reduction of peak pressure values (p = 0.011), in the moment after performing the techniques, and also in the Cdyn (p = 0.004) in the control group versus moment. Conclusions: Both maneuvers are safe in terms of hemodynamics and ventilatory mechanics, in addition to being capable of favoring airway clearance through secretion removal, and they can be used in routine physiotherapeutic care.
The Influence of Insecure Attachment to Parents on Adolescents’ Suicidality
Authors: Leben Novak Lara , Gomboc Vanja , Poštuvan Vita , De Leo Diego , Rosenstein Žiga , Drobnič Radobuljac Maja
Published: February 2023

Insecure attachment has been identified as a risk factor for adolescent psychopathology and, consequently, for suicidal behavior. We aimed to highlight the relationship between the attachment styles of adolescents and their suicidal behavior and to investigate the role of each parent in the suicidality pathway of adolescents. The sample consisted of 217 adolescent inpatients who were at the highest risk for suicidal behavior and who were hospitalized in the Unit for Intensive Child and Adolescent Psychiatry. Self-report questionnaires assessing their attachment to their parents, their acquired capability for attempting suicide, their suicidality, and a number of traumatic life events were administered. The results showed a higher level of attachment avoidance rather than attachment anxiety among the most at-risk adolescents. An acquired capability for suicide (ACS) mediated the positive correlation between adolescents’ attachment avoidance in relation to the mother or father and their suicidality. The suppressive mediating effect of an ACS on the association between attachment anxiety in relation to the father and suicidality was detected. The odds ratio for attempted suicide was more than two times higher for adolescents who were insecurely attached to their father compared to adolescents who were insecurely attached to their mother. Our results confirmed the importance of attachment, especially paternal attachment, in developing suicidality during adolescence. Preventive and clinical interventions should target these important domains with the aim of decreasing suicidality among adolescents.
Health-Related Quality of Life in Adult Patients with Strabismus—Translation and Psychometric Testing of the Adult Strabismus Questionnaire (AS-20) into Finnish
Authors: Mason Anna , Joronen Katja , Lindberg Laura , Koivisto Anna-Maija , Fagerholm Nina , Rantanen Anja
Published: February 2023

(1) Strabismus has an impact on individuals’ health-related quality of life. The impact should be assessed with valid patient-reported outcome measures such as the Adult Strabismus Questionnaire (AS-20). The AS-20 was further refined using a Rasch analysis for the American population. The aims of the study were to translate and culturally adapt the AS-20 into Finnish and to evaluate the psychometric properties of the Finnish AS-20. (2) The guidelines of the Professional Society for Health Economics and Outcomes Research steered the process and four items were added from the original data as Finnish additions. The construct and convergent validity and internal consistency were evaluated via psychometric testing for three potential Finnish AS-20 structures. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was applied. (3) The participants (n = 137) reported that the translation was clear and understandable. All structures showed high reliability and internal consistency as measured using Cronbach alpha values. The convergent validity assessed using Spearman’s correlation coefficients between the structures and one item of Satisfaction with Life Scale indicated very low to moderate positive correlations. The construct validity evaluated using a confirmatory factor analysis revealed the refined AS-20 structure to be satisfactory. (4) The refined AS-20 can be used in clinical practice and research, but further validation is recommended.
Colonization of Artificial Substrates by Invertebrate Macrofauna in a River Ecosystem—Implications for Forensic Entomology
Authors: Bartkowska Aleksandra , Mieczan Tomasz , Płaska Wojciech
Published: February 2023

Forensic entomology includes the analysis of organisms colonizing various parts of the body in order to determine the circumstances of an incident, mainly the time, place, and cause of death. The presence of insects and other arthropods on carcasses can be a source of knowledge for the judicial system. However, this type of research (on submerged bodies) is less published. The aim of our study was to analyse the qualitative and quantitative structure of macroinvertebrates colonizing potential evidence in an upland river. The experimental research involved an eight-week exposure to articles of clothing made of different materials: natural materials (bottom sediments with plants from a river), synthetic (socks), and cotton (t-shirts). Control samples of water after 2, 4, 6, and 8 weeks were taken from experiment locations in the River Bystrzyca with a tube apparatus and hand net. The results indicated that the abundance of organisms on a given substrate depended on the period of development of invertebrate macrofauna and the time of exposure of the substrates. The abundance of aquatic macrofauna on the exposed items increased in direct proportion to the duration of the experiment, which may indicate the adaptability of these organisms to new habitat conditions. Among the taxonomic groups used in forensic entomology, Diptera, Coleoptera, and Odonata were the most abundant. The remaining taxa (including Heteroptera), though not widely used in judicial proceedings, can also provide valuable information about the circumstances of an incident.