bluuebunny/crossref_metadata_2025 huggingface dataset:
Madhuca-longifolia-hydro-ethanolic-fraction reverses mitochondrial dysfunction and modulates selective GLUT expression in diabetic mice fed with high-fat-diet
Authors: Jha Dhruv , Prajapati Santosh Kumar , Deb Prashant , jaiswal mohit , Majumder Papiya Mitra
Published: July 2023

Metabolic disorders are characterized by chronic mild inflammation that elevates circulatory inflammatory markers. The proposed hypothesis behind this includes the occurrence of mitochondrial dysfunction, oxidative stress, and hypoxia due to a high-fat diet (HFD). In the present study, the effect of madhuca-longifolia-hydro-ethanolic-fraction (MLHEF) on HFD-induced obesity and diabetes through mitochondrial action and selective GLUT expression was studied. In this study, it was observed that chronic administration of HFD (50% of diet) aggravated metabolic problems by reducing ATP production, imbalanced oxidative stress, and altered GLUT expression. Chronic HFD administration significantly reduced (p < 0.001) the superoxide dismutase (SOD) and catalase (CAT) levels, as well as elevated the liver function markers aspartate aminotransferase (AST) and alanine aminotransferase (ALT). MLHEF administration reduces oxidative stress. HFD administration also decreased the ATP/ADP ratio owing to mitochondrial dysfunction and elevated lactose dehydrogenase (LDH) levels. This imbalance leads to altered GLUT expression in hepatocytes, skeletal muscles, and adipose tissue. HFD significantly (p < 0.001) upregulated in the GLUT 1 and 3 expression while significant downregulation (p < 0.001) was observed in GLUT 2 and 4 expression in the liver, skeletal muscles, and adipose tissue. Administration of MLHEF significantly (p < 0.001) reduced LDH levels and mitochondrial dysfunction. The imbalance in GLUT levels was significantly reversed to maintain GLUT expression in tissues following MLHEF administration.
Network Pharmacology Reveals the Potential of Dolastatin 16 as Diabetic Wound Healing Agent
Authors: Luthfiana Dewi , Utomo Didik Huswo
Published: July 2023

Dolastatin 16, a marine cyclic depsipeptide, was first isolated from the sea hare Dolabella Auricularia by Pettit et al. Since its bioactivity lacks of information, target identification is the indispensable strategy to reveal the potential target and mechanism of action of Dolastatin 16. Network pharmacology was utilized to identify the target associated with the disease, gene ontology, and KEGG pathway. The results demonstrated Matrix Metalloproteinase-9 (MMP9) as a potential target of Dolastatin 16 via network pharmacology analysis. The target was also mainly involved in TNF signaling pathway and foot ulceration-associated diabetic polyneuropathy. Further, the binding mode and dynamic behavior of the complex was investigated by molecular docking and molecular dynamics studies. In docking study, a native ligand (a hydroxamate inhibitor) and (R)-ND-336 were used as the ligand controls, demonstrating the binding energies of -6.6 and − 8.9 kcal/mol, respectively. The Dolastatin 16 complex showed the lowest binding energy of -9.7 kcal/mol, suggesting its higher potential as an inhibitor. Molecular dynamics also validated the stability of MMP9-Dolastatin complex throughout the simulation process. Dolastatin 16 may act as a MMP9 inhibitor and have potential to accelerate the wound healing process in diabetic foot condition.
Macroeconomic impact of an international fishery regulation on a small island country
Authors: Guillotreau Patrice , Dissou Yazid , Antoine Sharif , Capello Manuela , Salladarré Frédéric , Tidd Alex , Dagorn Laurent
Published: July 2023

This paper examines the macroeconomic impact of a tuna fishing regulation on a small island economy that relies heavily on tourism and fishing for foreign exchange earnings. While there is scientific consensus to limit the use of drifting fish aggregating devices (dFADs) worldwide, there is no agreement on their optimal number at sea. Resolution 23/02, adopted by the Indian Ocean Tuna Commission (IOTC) in February 2023, proposes a 72-day moratorium on dFADs, but this resolution faces opposition from many contracting parties, particularly developing countries. To understand the reasons for this opposition, a recursive multi-sector dynamic general equilibrium model is developed for the Republic of Seychelles, a small tuna-dependent country. The model assesses the short- and medium-term macroeconomic impacts of a seasonal dFAD closure in the Indian Ocean tuna fishery. The analysis suggests that a 12% decline in canned tuna exports would result in a -8.8% deviation from the trend in real Gross Domestic Product after seven years. Such an impact would have wide-ranging effects on the domestic economy, affecting all components of aggregate demand. Consequently, the economy would become more dependent on tourism, which has shown its vulnerability during the recent pandemic crisis. The study highlights the importance of considering social and economic aspects in sustainable fisheries management and provides insights into the potential consequences of dFAD regulations for small island economies.
JEL codes: Q22, D68, E65
Are public sector workers in Ghana overpaid? Evidence from a Blinder-Oaxaca decomposition analysis.
Authors: Kaba Jeffrey
Published: July 2023

This paper employs the Blinder-Oaxaca decomposition method to estimate the private-public sector wage gap, investigating the public sector wage premium using an analytical sample of 876 wage workers. These workers were drawn from a nationally representative household dataset - the seventh round of the Ghana Living Standards Survey (GLSS 7) data. The results suggest that private sector workers, including those in the informal sector, earn lower wages than their counterparts possessing the same level of human capital in the public sector. Returns to education in the public sector surpass those in the private sector, particularly for the less educated. However, the wage gap becomes statistically insignificant when observed among formal private sector workers and formal public sector wage workers, a consistency with public sector wage compression. These findings contribute to the ongoing debate about private-public wage differentials by introducing context-specific insights from Ghana, particularly when comparing the wages of formal private and public workers. Although the results challenge the common belief that private sector workers receive significantly less premium than public sector workers, this paper underlines the importance of formalizing the predominantly informal private sector as a policy measure to reduce the private-public wage gap.
JEL classifications J24, J31, J45, J46
Ethnobotanical and biochemical features of Sesbania sesban L. Merr., a nitrogen-fixing plant native to the Republic of Chad
Authors: Mahamat Ousman Brahim , Younes Saoud , Otchom Boy Brahim , Franzel Steven , Hidjazi Al-Djazouli Ouchar Mahamat , Soumaya El Ismaili
Published: July 2023

This study reports on a literature review of the leguminous tree Sesbania sesban (L.) Merr, which is found in the N'Djamena region, the Republic of Chad. The study focused on S. sesban’s phytochemical features and its use as a medicine and fodder to assist in future evaluations. A literature review using international academic websites, such as Science Direct, Springer, Nature, plant databases, and data from national herbaria was done. S. sesban is a perennial shrub or tree that measures 3–4 meters in height. This species is becoming rare in Ndjamena but can be found in some gardens of some institutions in Ndjamena such as the Higher Institute of Educational Sciences (ISSED). The local inhabitants in Chad use the species as medicine, livestock feed, fuel-wood, and for improving soil fertility and repelling desert encroachment. Traditional healers use its leaves to treat breast cancer and edema. S. sesban is an essential species native to the Republic of Chad that needs conservation and valorization. Viewing its rarity in N’Djamena today, a strategy of replanting the species in gardens, homes, and fields around Ndjamena and other regions of Chad is recommended.
Wealth, Poverty and Gnostics (Part I)
Authors: Пантелеев А.Д.
Published: July 2023

Во II–III вв. существовала группа гностических течений, считавших демиурга, бога-творца низшего материального мира, не добрым или злым, а справедливым. Это валентиниане Гераклеон и Птолемей, сын и ученик гностика Карпократа Епифан, авторы сочинений «Трехчастный трактат», «Ипостась архонтов» или «О происхождении мира» из собрания Наг-Хаммади. Эти гностики утверждали, что он заботится о духовных людях – пневматиках, имеющих в своей душе частицу света. Они ощущали себя частью не только высшего, духовного мира, но и в какой-то мере этого, материального, и были нацелены на позитивное взаимодействие с римскими властями и языческим обществом в большей степени, чем церковные христиане. Взгляд на демиурга как защитника и покровителя позволял решить многие вопросы, в том числе проблему отношения к земному богатству. Демиург заботился о душах, имевших в себе духовное зерно, он или помещал их в тех, кто родился в знатных и богатых семьях, или возвышал и обогащал этих пневматиков. Богатство, таким образом, не стигматизировалось, а превращалось в знак избранности и элитарности.

In the 2nd–3d centuries there was a group of Gnostic movements that considered the Demiurge — the creator of the lower material world — neither good no evil, but just. They claimed that he cares about pneumatics, who have a part of higher light in their soul. We can remember the Valentinians Heracleon and Ptolemaeus, the son and disciple of Carpocrates Epiphanes, the authors of the "Three-part Treatise", "Hypostasis of the Archons" or "On the Origin of the World" from the Nag Hammadi Library. These Gnostics felt themselves as a part not only of the higher, spiritual world, but also to some extent of this, material, and they were aimed at positive interaction with it. The view of the Demiurge as a protector and patron allowed to solve many issues, including the problem of attitude to earthly wealth. The Demiurge took care of the souls who had a spiritual seed, he placed them in noble and rich families, and elevated and enriched these pneumatics. Wealth was not stigmatized by them but turned into a sign of being chosen and elitism.
Intellectuals of Piedmont in the Time of Napoleon: Between Ideological Loyalism and Forced Adaptation
Authors: Митрофанов А.А.
Published: July 2023

В статье на примерах биографий пьемонтских политиков и интеллектуалов Просперо Бальбо, Карло Ботты, Гаспаре Морардо и Карло Босси рассматривается воплощение наполеоновской политики «амальгамы» в Пьемонте начала XIX в. Идея соединения и селекции элит относится к числу главных в интеграционном проекте Наполеона Бонапарта. В основу этой политики был положен принцип лояльности новому режиму. Как мы видим на конкретных примерах рубежа XVIII–XIX вв., лояльность могла быть выражена разными способами и требовала адаптации к новым социальным и политическим обстоятельствам, принятия новых правил. Принцип лояльности, однако, был совмещен с принципом персональной значимости того или иного функционера. Очень многое в процессе распределения новых статусов зависело только от самого Наполеона. Труднее всего приходилось тем, кто прочно связал свою карьеру с республиканским режимом 1799 г. Неудачный в целом опыт республиканских правительств в Пьемонте давал основания французской администрации удалять таких деятелей из политической жизни этого региона и заменять их на тех, кто отличался умеренностью взглядов и большей гибкостью. Наибольшей способностью адаптироваться обладали такие опытные люди как Бальбо, для которых сфера управления и в новых имперских условиях была родной стихией.

In this article, using specific examples of the biographies of Piedmontese politicians and intellectuals - Prospero Balbo, Carlo Botta, Gaspare Morardo and Carlo Bossi, the author analyzes the implementation of the Napoleonic policy of «amalgam» in Piedmont at the beginning of the 19th century. The idea of ​​uniting and selecting elites is one of the main ones in the integration policy of Napoleon Bonaparte. This policy was based on the principle of loyalty to the new regime. As we can see from specific examples of the turn of the 18th-19th centuries, loyalty could be expressed in different ways and required adaptation to new social and political circumstances, the adoption of new rules. The principle of loyalty, however, was combined with the principle of the personal importance of this or that functionary. A lot of things in the process of distribution of new statuses depended only on Napoleon himself. It was hardest of all for those who firmly linked their careers with the republican regime of 1799. The generally unsuccessful experience of the republican governments in Piedmont gave reason to the French administration to remove such figures from the political life of this region and replace them with those who were distinguished by moderation of views and greater flexibility. Experienced people like Balbo had the greatest ability to adapt, for whom the sphere of government was their native element even in the new imperial conditions.
Russia and Great Britain: The National Factor in the Competition of the Great Powers
Authors: Демешко Н.Э. , Ирхин А.А.
Published: July 2023

В статье раскрываются модели этнонациональной политики России и Великобритании, а также технологии актуализации и использования национального фактора в российско-британской конкуренции XIX–XXI вв. Авторы рассматривают национальный вопрос как один из инструментов противостояния великих держав, поскольку язык, религия, «зов крови», конструирование национальных мифов о «золотом веке» и идентификация врага, лишившего нацию былого величия, порождают раздвоенность элит малых народов, ориентирующихся на противоборствующие геополитические центры в борьбе за власть и ресурсы внутри национальных общин.

The article reveals the models of the ethnonational policy of Russia and Great Britain, as well as the technologies of actualization and playing out the national factor in Russian-British relations of the XIX–XXI centuries. The authors consider the national question as one of the instruments of competition of the great powers. Since language, religion, the "call of blood", the construction of national myths about the "golden age" and the identification of the enemy who deprived the nation of its former greatness, give rise to a split of the elites of small nations, focusing on opposing geopolitical centers in the struggle for power and resources within national communities.
Practices of reforming the political sphere of Russian society in the early XX century in the perception of contemporaries
Authors: Селунская Н.Б.
Published: July 2023

В статье предпринята реконструкция многообразного восприятия практик по реформированию политической сферы Российской империи начала ХХ в., сохраненного в памяти современников, наблюдателей от правительственной власти, инсайдеров процесса обновления институтов власти, депутатов народного представительства, писателей и журналистов, авторов брошюр, рефлексирующих над событиями «российской весны». Применение методологии “memory studies”, а также дискурсивного анализа к текстам эго-документов позволило реконструировать эмоциональные и противоречивые оценки современниками влияния на процессы обновления российского общества «исторических традиций», в том числе, почтенной традиции бюрократического самовластия, которая «тяготеет над русским народом целые века, ей мы обязаны целым рядом экспериментов над нашим государственным организмом», пагубно влиявшая на трансфер и адаптацию на российской почве «свобод», культуры выбора. Другим значимым ракурсом восприятия современниками трансформаций, связанных с появлением института народного представительства, является их видение роли разных типов конфликтов «власти» и «общества», как, например, неудачный опыт взаимодействия «власти с неостывшей обидой побежденного и народных представителей с злорадным торжеством победителей» которые стали причиной «стремительного драматического конца российского парламента».

The article attempts to reconstruct the diverse perception of the practices of reforming the political sphere of the Russian Empire at the beginning of the 20th century, preserved in the memory of contemporaries, observers from government authorities, insiders of the process of updating government institutions, deputies of the people's representation, writers and journalists, authors of brochures reflecting on the events of the “Russian spring”. The application of the “memory studies” methodology, as well as discursive analysis to the texts of ego-documents, made it possible to reconstruct the emotional and contradictory assessments by contemporaries of the influence of “historical traditions” on the processes of renewal of Russian society, including the venerable tradition of bureaucratic autocracy, which “gravitates over the Russian people for centuries, we owe it a whole series of experiments on our state organism”, which had a detrimental effect on the transfer and adaptation on Russian soil of “freedoms”, a culture of choice. Another significant perspective of the perception by contemporaries of the transformations associated with the emergence of the institution of popular representation is their vision of the role of different types of conflicts between “authority” and “society”, such as the unsuccessful experience of interaction between “authority with the unrelenting resentment of the defeated and people’s representatives with malicious triumph winners" which caused "the rapid dramatic end of the Russian parliament".
“You Will Quickly Find Tynda on the Map…”: Late Soviet School Local Studies and Images of the City in Educational Literature
Authors: Степанов Б.Е.
Published: July 2023

В центре исследования находится вопрос о роли школьного краеведения в формировании городского воображения в позднесоветском обществе. Одним из результатов возрождения краеведения в послевоенный период стало появление корпуса учебных пособий, призванных содействовать знакомству учащихся с местной природой и историей. Изучая изданные в 1960–1980-х гг. региональные учебники для 3–4-го класса в связи с вопросом репрезентации в них города, автор делает выводы о специфике развития школьного краеведения и, в частности, по сравнению с предшествующими и последующими периодами его развития.

The paper focuses on the role of school local studies (kraevedenie) in shaping the urban imagination in late Soviet society. One of the results of the revival of local studies in the post-war period was the emergence of a corpus of textbooks designed to supplement students' knowledge of local nature and history. Having selected the corpus of history and natural history textbooks for 3rd-4th grades, published in the 1960s-1980s by regional publishers, as the source material for the study, the author draws conclusions on the specific development of school local studies and, in particular, the representation of the city in them compared with previous and subsequent periods of its development.
ДВЕ ВСТРЕЧИ РУССКИХ ПОСЛОВ С ДАВИДОМ ХИТРЕУСОМ
Authors: Местковский Д.Д.
Published: July 2023

В предпринята попытка проследить изменения во взглядах немецких протестантов на православие в конце 1570-х – начале 1580-х гг., которые хорошо проявились в двух разных описаниях одного и того же события (воспоминания и впечатления от личной встречи с русскими послами) в письмах Давида Хитреуса. Делается вывод о том, что общее разочарование ходом переписки тюбингенских теологов с патриархом Иеремией II заставило Хитреуса более трезво подойти к вопросу о доктринальном сходстве православия и протестантизма.

This article attempts to trace the changes in Protestants’ views on Orthodoxy in the late 1570’s and early 1580’s. These changes are well observable in two accounts of the same event (impressions from personal meetings with Russian ambassadors) in the letters of D. Chytraeus. It is concluded that the general disappointment with the course of correspondence between the Tübingen theologians and Patriarch Jeremiah II compelled D. Chytraeus to describe similarities between Orthodoxy and Protestantism more circumstantially.
L.D. Trotsky and the 1922 Campaign to Seize Church Property (On the 100th Anniversary of the Seizure of Church Property)
Authors: Володько А.В.
Published: July 2023

В 2022 г. исполнилось 100 лет одному из трагических событий в истории России – кампании по изъятию церковных ценностей, организованной большевистским правительством под предлогом помощи голодающим с целью пополнения государст-венной казны и смены власти в Русской православной церкви. В статье представлен анализ основных этапов деятельности Л.Д. Троцкого, одного из главных идеологов и организаторов этой кампании. При подготовке статьи были использованы материалы Российского государственного архива социально-политической истории, Государственного архива Российской Федерации и документы, опубликованные в сборниках «Архивы Кремля. Политбюро и церковь», «Русская православная церковь и коммунистическое государство 1917–1941» и др.

The year 2022 marks the 100th anniversary of one of the tragic events in Russian history - the campaign to seize church treasures, organised by the Bolshevik government under the pretext of helping the starving to replenish the state treasury and change the power in the Russian Orthodox Church. The article presents an analysis of the main stages of the activity of L. D. Trotsky, one of the main ideologists and organizers of this campaign. In preparing the article the archival materials of the Russian State Archive of Social and Political History, the State Archive of the Russian Federation, as well as documents published in the collections "The Kremlin Archives. Politburo and Church", "The Russian Orthodox Church and the Communist State 1917-1941" and others.
Transcriptome Analysis Reveals the Molecular Mechanism of Grape Inflorescence Elongation after Applying Microbial Fertilizers
Authors: Huang Qiufeng , Chen Guopin , Xie Shuyu , Li Wei , Huang Jing , Huang Yu , Guan Jingxi , Cao Muming
Published: July 2023

Microbial fertilizers can activate and promote nutrient absorption and help inflorescence elongation. To understand the molecular mechanisms governing grape (Vitis vinifera) inflorescence elongation after microbial fertilizer application, we comprehensively analyzed the transcriptome dynamics of ‘Summer Black’ grape inflorescence at different leaf stages. With the development of ‘Summer Black’ grape inflorescence, gibberellic acid content gradually increased and was clearly higher in the microbial fertilizer group than in the corresponding control group. In addition, the microbial fertilizer and control groups had 291, 487, 490, 287, and 323 differentially expressed genes (DEGs) at the 4-, 6-, 8-, 10-, and 12-leaf stages, respectively. Kyoto Encyclopedia of Genes and Genomes pathway annotation revealed that most upregulated DEGs were enriched in starch and sucrose metabolism pathways at the 6-, 8-, and 10-leaf stages. Weighted gene coexpression network analysis identified stage-specific expression of most DEGs. In addition, multiple transcription factors and phytohormone signaling-related genes were found at different leaf stages, including basic helix-loop-helix proteins, CCCH zinc finger proteins, gibberellin receptor GID1A, 2-glycosyl hydrolases family 16, protein TIFY, MYB transcription factors, WRKY transcription factors, and ethylene response factor, suggesting that many transcription factors play important roles in inflorescence elongation at different developmental stages. These results provide valuable insights into the dynamic transcriptomic changes of inflorescence elongation at different leaf stages.
Extensive lipoma in chin region- A rare case report
Authors: Nair Vivek , N Anusuya , Sane Vikrant , Sankar Kannan
Published: July 2023

Lipomas are common soft tissue tumors, but occur infrequently in the oral and maxillofacial region. Incidence of oral lipomas are noted to be only 1 - 4.4% with common sites being buccal mucosa followed by lips, tongue and vestibule. In this paper we would like to report a rare case of an extensive lipoma in the chin region.
Simultaneous placement of direct nd indirect transfer copings at implant level impression -A case report
Authors: Vasantha  , Soni Preet , Mundhe Darshana , Patil Rupali
Published: July 2023

Implant level impressions are usually made with custom trays. This article describes the simultaneous use of open and closed tray transfer copings using stock tray.
A Comparative Evaluation of Different Methods PF Cleaning and Preparing Occlusal Fissures, Before Placement of Pit and Fissure Sealant: A Stereomicroscopic Study
Authors: Mohd Taiyab Ansari  , Monika Koul Verma  , Ahsan Abdullah
Published: July 2023

Aim and objective The study was aimed to comparatively evaluate the effect of different methods of cleaning and preparation of occlusal surfaces on microleakage of pit and fissure sealant. Materials and method: Eighty (80) sound extracted premolars served as samples and were divided into four categories according to the method of cleaning and preparation of occlusal surfaces. Prior to sealant placement. The groups were: A Dry Brush, B Pumice Slurry Air Polishing and D Prophylaxis Paste. In each group, subsequent to cleaning of occlusal surfaces with the method assigned to, pit and fissure sealant was applied. The samples were then kept in an incubator, thermocycled and then immersed in methylene blue dye. Each tooth was sectioned longitudinally into two halves and observed under stereomicroscope for microleakage using a criteria given by Cooley et al. Statistical analysis: Discrete microleakage score of groups is summarized in number (n) and percentage (%).Result: Comparing the microleakage score of four groups, χ2 test showed significantly different microleakage score among the groups (χ2 =33.96, P <0.001). Conclusion: Microleakage score showed both pumice slurry (Group B) and especially air polishing (Group C) to be significantly more superior than prophylaxis paste (Group D) and dry brush (Group A).
Management of A Case of Fibro-epithelial Hyperplasia of Gingiva
Authors: Pati Ritam Chandra , Agarwal Swati , Farheen  , Thakuria Anurag
Published: July 2023

ABSTRACT:

Fibroepithelial hyperplasia/fibroma is an exophytic growth which occurs due to any reactive or chronic inflammatory condition of the gingiva by plaque, calculus, overhanging margins, trauma and dental appliances. These can cause discomfort to the patient and often causes difficulty in oral hygiene maintenance. This case report presents a case of a fibro-epithelial hyperplasia in a 37 years old female, who presented with a localized diffuse type of gingival enlargement in the left maxillary posterior teeth region. Based on clinical and histopathological evaluation the diagnosis of fibro-epithelial hyperplasia was made. The patient was then kept on regular follow-up and no recurrence of the lesion could be appreciated till date.
Punicagranatum as a local drug delivery system: A Clinico microbiological study
Authors: Gupta Shikha , Pandit Aashish , Mathur Setu , Aggarwal Manoj
Published: July 2023

The use of herbal/ natural compounds can be comparatively safer alternative to those of synthetic compounds for periodontal therapy. The present study aims to investigate the effect of pomegranate extracts in form of chip for treating adult patients affected with periodontitis followed with scaling and root planing. The study was conducted in two parts: Invitro and Invivo. The study was a randomized controlled study and was addressed by clinical and microbiological parameters at base line and subsequent intervals.

Material and methods:In vitro release was performed by using Keshary-chien diffusion cell for randomly selected strip. In vivo30patients with adult periodontitis having initial pocket depth ≥4 mm were enrolled into this research. For each subject two experimental sites were chosen located in symmetrical quadrants. Sites were randomly assigned to control group or test group. Then subgingival application of medicated chips was done in both groups. The clinical parameters were recorded at baseline, 30 days and 90 days. Descriptive statistical analysis has been carried out in present study.

Results: The in vivo study confirmed significant improvements of plaque index ratings with significant reduction in gingival index, plaque index and relative attachment level scores at 90 days as compared to control group. While Porphyromonasgingivalis ,Prevotellaintermedia , Fusobacteriumintermedia and Aggregatibacteractinomycetemcomitans showed a more significant reduction at 90 days as compared to control group. In vitro results showed complete drug release in – 72- 80 hours .Matrix degrades between 3 to 4 days. Pomegranate extracts in chip may provide additional advantages to scaling and root planing for improving periodontal status.

KEYWORDS: Chip, gingiva, periodontal, pomegranate, punicagranatum
A nonsurgical approach in management of burns induced microstomia: a review
Authors: Agrawal Ruchi , Choukse Vivek , Aidasani Ashwin , Gandagule Ranjeet
Published: July 2023

Burns of head and neck region causes skin contracture which will result in microstomia and loss of skin flaccidity. The prevention and management of microstomia contracture is an important aspect of facial burn. The goal of microstomia repair include the reconstruction of orbicularis sphincter for adequate lip functioning, obtaining lip symmetry and well positioned scar and adequate mouth opening. The standard treatment for the prevention and management of contracture includes compression therapy, grafting, mouth splinting, scar massage, excercise, patient education. These types of maxillofacial prosthetic appliances may be indicated, in conjunction with or without surgery these appliances can be use to improve the reduced mouth opening  caused by burns or other traumatic injuries With proper education and motivation of operator and the patient use of these appliances will not only improve the reduced mouth opening but also improve  form, function, esthetics, and also enhance the patient’s quality of life.
Clinical Establishment Act: A Review
Authors: Diya Kumari  , Vaibhav Tandon
Published: July 2023

The Clinical Establishments (Registration and Regulation) Bill 2007 reiterates the concerns of the Working Group in its statement of objects and reasons. This is an Act that is proposed to be brought into force to streamline the functioning and provision of services by clinical establishments. Importantly, it is a matter that regulates not just allopathic facilities, but also clinical establishments that provide services in a range of Indian systems of medicine. The relevance of this enactment lies in the fact that there has been an increasing concern about the gross inadequacy of public health facilities on the one side and the lack of any standards to regulate the existing facilities – both public and private – on the other.
A Rare case of Ectopic tooth associated with Dentigerous cyst in maxillary sinus
Authors: Gupta Rahul , Singh Vikas Kunwar , Tiwari Ruchika , Jamwal Tamanna
Published: July 2023

Ectopic eruption of teeth may be associated with developmental disturbances, pathologies or may be iatrogenic. Ectopic eruptions of 3rd molar in maxillary sinus is relatively rare. This article reviews a 30 year male who reported to the out-patient department of Oral and Maxillofacial Surgery with complaint of pain and swelling in upper left side of the face since 15-20 days. Orthopantomogram revealed an impacted tooth in left maxillary sinus with cystic lining. Provisional diagnosis of dentigerous cyst in relation to ectopic tooth was made. Surgical removal of the tooth from the maxillary sinus using a standard Caldwell-Luc approach is the treatment of choice along with removal of the associated pathology. Asymptomatic cases should be managed similarly as the tendency to form cyst or tumor is possible.
Reattachment of Fractured Maxillary Central Incisor Crown Using Fiber Post: A Case Report.
Authors: Mundra Rohit
Published: July 2023

ABSTRACT: Dental fractures comprise the most frequent form of traumatic dental injury and often require an immediate procedure for their treatment. Among the treatments, the restoration of fractured teeth by reattachment of the tooth fragment to its tooth remnant is a viable clinical procedure to treat tooth fracture due to trauma because it is considered a highly conservative technique.
Ranula of the sublingual area
Authors: Gaur Anuj , Kankariya Hasti , Kumari Niharika , Deka Anumita
Published: July 2023

Ranula is a cystic fluid filled cavity that is caused by extravasation of the sublingual gland at the floor of the mouth. Ranula originates in the body of the sublingual gland, especifically in the Rivinus ducts of the sublingual gland, and occasionally originates in the minor salivary glands at the floor of the mouth .There are a variety of treatment modalities for ranula including aspiration of the cystic fluid, sclerotherapy, marsupialization, incision and drainage, ranula excision only, and excision of the sublingual gland with or without the ranula. In this article we present a case report of a ranula, which developed after the extraction under lingual nerve block on the same side.
Free Fibula Flap in Mandibular Reconstruction : A Case Report
Authors: Yadav Shiwangi
Published: July 2023

The reconstruction of the mandible is a complex procedure and continues to be a challenge in reconstructive maxillofacial surgery. Indications for mandibular reconstruction are varied and include pathological resections, traumatic injuries and residual deformities amongst others. The mandible is an important anatomical unit of maxillofacial skeleton in terms of both aesthetics and function which necessitates its immediate reconstruction after resection.

A 16 years old female patient, diagnosed with ameloblastoma of left hemi -mandible underwent resection with immediate reconstruction using free fibula flap. Twenty two months follow up reveals excellent bony union and facial contours. The objective of the treatment is to resecting the mandibular defects and reconstruction with free fibular flap.

Our experience combined with positive literature references enhances the reliability of free fibular vascularized graft as a suitable and versatile reconstructive option for complex anatomical contours of the mandible.
The Comparison of the effect of two different doses of methylprednisolone on pain, swelling and trismus after 3rd molar surgery.
Authors: GARG KAMAL
Published: July 2023

Objective  The aim of this study was to compare the effects of intravenous administration of 1.5mg/kg and 3mg/kg of methylprednisolone sodium succinate on pain, swelling and trismus after third molar surgery.

Study Design.  Twenty five healthy patients with bilaterally symmetrical impacted mandibular third molars were included in this study. Either 1.5mg/kg or 3mg/kg of methylprednisolone was administered by intravenous route 1 hour before the operation. At the second operation the other dose was applied. Facial swelling was evaluated by using cotton sutures. Trismus was determined by measuring maximum interincisal opening. Pain was determined by using visual analogue scale.

Results. There was no statistically significant difference in pain swelling and trismus  between the two groups.

Conclusion.  No significant benefit of higher dose of methylprednisolone administered.
Laser assisted therapeutical approach for the treatment of Ankyloglossia.
Authors: C.S. Baiju  , Meenu Taneja Bhasin  , Gupta Gunjan , N. D Gupta  , Rinu Reju
Published: July 2023

Ankyloglossia also known as tongue-tie limits the tongue’s motion due to short, thick lingual frenum. In this article, we have reported two cases, a 35-year-old female referred for tongue-tie removal and a 34-year-old male patient with a tongue tie who complained of difficulty in speech following which both of them underwent laser assisted frenectomy procedure under local anesthesia. The postoperative period was uneventful.
Knowledge, attitude and practices of dentists of Aligarh and Mathura regarding COVID -19 pandemic – A cross-sectional survey
Authors: Mariam Sarah , Agrawal Neha , Gupta Narinder Dev , Tewari R K
Published: July 2023

This study was carried out to analyze knowledge, attitude, and practice (KAP) of Dentists of Aligarh and Mathura regarding the Covid-19 pandemic. This cross-sectional study used a 16-item pre-tested and validated questionnaire based on the Covid 19 pandemic, which was then disseminated through the internet to all dentist members of the Indian Dental Association, Aligarh and Mathura during November, 2020 . The 'General part-A' of the questionnaire covered the individuals' socio-demographic and professional informations (age, gender, educational status, type of practice etc.). Part B comprised of 16 questions pertaining to COVID-19 knowledge, attitudes, and practises. A total of 260 dentists participated in the survey. The study included a higher percentage of females, BDS, and practitioners with fewer than 10 years of expertise. The participants' average knowledge, attitude, and practise score was 13.21 ±1.67. In the current study, socio demographic factors such as gender, educational level, experience in dentistry, and professional affiliation were found to have statistically significant (p 0.05) relationships with mean knowledge. Although there were notable deficiencies in some key areas, the results of this investigation revealed that the majority of the subjects had adequate knowledge, a positive attitude, and took precautions when dealing with patients, although there were notable deficiencies in some key areas. As a result, ongoing educational initiatives/webinars should be planned on a regular basis.
Analysis of a three-dimensional numerical modeling approach for predicting scour processes in longitudinal walls of granular bedding rivers
Authors: Calixto Nelson Cely , Zambrano Melquisedec Cortés , Castaño Alberto Galvis , Soto Gustavo Carrillo
Published: July 2023

In rivers, longitudinal walls are protective structures that are directly supported on the riverbank are frequently used as hydraulic prevent the current from eroding the bank and causing scouring. However, these structures have the potential to block flow and produce erosive processes that progressively worsen scour in their area, leading to faulting and other problems. The current study used Flow-3D software to understand the scour process at the base of longitudinal walls in rivers with a well-graded granular bed. Experimental data from a physical model replicating a river with a longitudinal wall and a well-graded granular bed were used to validate the model. The investigation examined the average flow velocity and its effects on scour behavior along the longitudinal wall using the Flow-3D program. The findings showed that the Flow-3D model could improve the evaluation of debugging processes, because it provided a useful answer that closely matched the experimental data derived from the physical model. Validation with a 0.07 m mesh demonstrated that the Flow-3D model could faithfully simulate the scour process along the longitudinal wall. Overall, the findings of this study suggest that the Flow-3D software can be a useful tool for predicting the scouring process in rivers with well-graded granular beds and longitudinal walls. This is particularly important for engineers and researchers who are interested in designing and optimizing hydraulic structures to mitigate the effects of scouring, because it provided a useful answer that closely matched the experimental data derived from the physical model
Topology optimization of isotropic elastic materials in the two-dimensional design domain with changes in characteristic boundary conditions
Authors: Tran Ngoc-Tien
Published: July 2023

Topology optimization (TO) has become increasingly popular as a useful tool for designers and engineers during the initial stages of design. TO aims to optimize the geometry of a design to achieve a specific objective, which can range from discrete grid-like structures to continuum structures. In essence, the geometry is parameterized pixel-by-pixel, with the material density of each element or mesh point serving as a design variable. After that, the optimization problem is addressed using mathematical programming and analytic gradient calculation-based optimization approaches. In this paper, we investigate the material distribution when performing topology optimization for an isotropic material with boundary conditions including fixed structures, supports, or external forces changing. In addition, we investigate more cases where there are material holes in the design domain, meaning that the density of the material is zero. In this study, the modified SIMP method and filter sensitivity are used for topology optimization. The results of the study are the optimized structural domains and the change in compliance according to the number of iterations. The results indicate that the compliance value of most structures reaches convergence after optimization up to the 20th iteration. Moreover, if the force applied to the design domain is symmetrical, the optimal structure also exhibits symmetry. Thus, the distribution of material is concentrated at the positions of the supports. Topology optimization produces designs that both meet boundary conditions while saving material and reducing their mass. The results obtained are important data for structural optimization design for isotropic elastomeric materials. From there, it can be applied to real objects with different requirements and conditions
A multi-criteria decision-making in relieving grinding process of surface of gear milling tooth based on the archimedean spiral using taguchi-ahp-topsis method
Authors: Nguyen Kien Huy , Pham Dong Van , Tran Quoc Ve
Published: July 2023

In this study, in order to optimize the quality criteria of the machined surface based on the Archimedean spiral, the relieving grinding process (RGP) was performed to machine the material of HSS P18 in a 1Б811 machine with four input parameters including graininess of grinding wheel (G), grinding wheel hardness (Hd), velocity of grinding wheel (V), and feed rate (s) and with three quality criteria including surface roughness (Ra), hardening of surface layer (∆HRC), and hardened layer thickness (∆L). Taguchi-AHP-Topsis method was successfully applied to solve the Multi-Criteria Decision Making (MCDM) problem in this case. The optimized results of the output parameters are surface roughness of 0.21 µm, surface hardening of 1.45 HRC, and hardened layer thickness of 34.18 µm. These results were determined at the set of the input parameters includes G, V, s with their values of 120, 24 m/s, 2.08 m/min, respectively, and Hd at level 1. The optimal results were verified through the comparison between the calculated and the experimental results using this set of optimal parameters. The differences between the calculated results and the experimental results were quite small (maximum different value was 4.8 %) Thus, the results of this study can be applied to solve the multi-objective optimization problems in RGP of the GMT surface based on the Archimedean spiral
A fully balanced first order high-pass filter
Authors: Obma Jagraphon , Jantakun Adirek , Sa-ngiamvibool Worawat , Suksawad Atirarj
Published: July 2023

The topic of this article is the design of a fully balanced first-order high-pass filter and its two circuits. The first circuit is a fully balanced current-tunability first-order high-pass filter consisting of four NPN transistors and a single capacitor, which is a simple design and quite compact. The pole frequency can be adjusted with a bias current. The results of the first circuit shows the phase and gain responses, the phase and gain responses when adjusted with a bias current, the time-domain response, and the harmonic spectrum. However, this circuit found a flaw in the temperature that affects the pole frequency, and total harmonic distortion is relatively high. Therefore, the second circuit improves defects by the CAPRIO technique to reduce the total harmonic distortion, and the resistors in the circuit are added to the design to replace the resistance and the effect of temperature on the properties of the transistor. This circuit consists of four NPN transistors, four resistors, and a single capacitor. The resistors in this circuit can be adjusted to change the pole frequency and voltage gain. The results of the second circuit show the gain and phase responses of the proposed circuits, the phase and gain responses when adjusted to the value of the resistor, the phase and gain responses at various temperatures, as well as their time-domain responses and total harmonic signal distortion. The all-pass filter is also made using the filter introduced in the second circuit because of its voltage gain-adjustable property. So, if the suggested circuit is constructed in combination with a buffer circuit to make it feasible to function as an all-pass filter, the result will be an all-pass filter. In accordance with the results of this study, we have introduced a design for a high-pass filter to reduce total harmonic distortion and the effect of temperature
Development of a calculation scheme for selecting the optimal mode of operation of a gas condensate well taking into account the deformation conditions of the formation
Authors: Abbasova Samira , Mammadova Gulbahar
Published: July 2023

To establish premature optimal well operation modes, it is necessary to consider the process of well operation within the framework of ongoing processes in the common reservoir-well hydrodynamic system and take into account the peculiarities of changes in the properties of the gas condensate mixture and the thermobaric conditions of the reservoir in it. Therefore, the object of the study is the operation of a gas condensate well in the event of technological complications in it, which requires the selection of the necessary optimal operating mode to prevent these complications by comprehensively taking into account the factors influencing this process in the “reservoir-well” system.

The article proposes a calculation scheme for establishing the optimal operating mode of a gas condensate well without the formation of a liquid plug at the bottomhole, taking into account the formation deformation during field development in the depletion mode. The problem is solved by determining the required current working volume of produced gas (as well as condensate), bottomhole and contour values of reservoir pressure, condensate saturation and reservoir porosity. As a result of the study, it was revealed that the determined characteristics of the selected optimal mode of a gas condensate well are significantly affected by a change in the reservoir properties of the reservoir (for example, the permeability of the reservoir), which in turn leads to a change in the optimal working gas flow rate of the well.

The considered problem has not been previously studied in its full formulation, which is presented in this article, where the solution of the problem under study is achieved taking into account the change in the physical properties of the reservoir fluid and gas, as well as the reservoir properties of the reservoir under conditions of a change in the state of the reservoir system due to emerging deformation processes in the reservoir