bluuebunny/crossref_metadata_2025 huggingface dataset:
More Than 7 Years of Hindsight: Revisiting the FDA’s 2008 Guidance on Cardiovascular Outcomes Trials for Type 2 Diabetes Medications
Authors: Regier Emily E. , Venkat Manu V. , Close Kelly L.
Published: October 2016

IN BRIEF Concerns raised about the cardiovascular safety of type 2 diabetes medications such as rosiglitazone prompted the U.S. Food and Drug Administration to issue draft guidance in 2008 that, in practice, has required large cardiovascular outcomes trials (CVOTs) for all new type 2 diabetes therapies. After more than 7 years and six completed and published trials to date, this is an opportune time to consider whether these studies, as currently designed and conducted, accurately assess the long-term benefit/risk profile of new therapies and whether they represent an optimal use of limited health care resources. This article presents and contextualizes opinions on CVOTs from 10 thought leaders in diabetes. It is intended to inform an exploration of the costs, medical ethics, and effectiveness of using large-scale CVOTs to assess the safety of new diabetes therapies.
From West End to Eastside: The Vancouver HIV/AIDS Epidemic, 1983–2013
Authors: Perry Taylor
Published: October 2016

Traditional histories of AIDS have used a few major American urban centres as proxies for the North American epidemic more broadly and have tended to frame the epidemic as a quintessentially gay and American experience. A careful examination of how the epidemic unfolded in Vancouver, British Columbia, however, reveals considerable differences, including the relative absence of local gay activist traditions prior to HIV/AIDS and the relative prominence of interventions such as Insite, North America's first sanctioned needle exchange program and safe injection site. An investigation of such differences emphasizes the local character of the epidemic and adds a Canadian perspective to the existing AIDS historiography.
La « psychose débutante » comme catégorie productrice de normes médicales. Contribution à l'histoire des pratiques de santé, France-Allemagne, 1945–1989
Authors: Delille Emmanuel
Published: October 2016

La catégorie de psychose débutante fait partie des classifications médicales usuelles, à la fois au seuil des savoirs qui constituent l'ossature du champ de la santé mentale, et catégorie normative, susceptible de donner une signification médicale à un ensemble de conduites d'abord identifiées comme bizarreries de comportements, propos, émotions et états mentaux étranges, puis requalifiées en tant que prodromes d'une maladie mentale. De plus, elle fait l'objet de nombreuses publications depuis les années 1990, sans que l'on sache quelles furent vraiment les pratiques de santé dans le passé, avant d'être un objet de protocoles standardisés de recherche, de prévention et de soin. En nous appuyant principalement sur les archives de l'Hôpital de Bonneval, et en établissant des rapprochements et des différences avec d'autres hôpitaux français et allemands dans les années 1950 à 1980, nous donnons des exemples de son maniement dans la clinique, à partir d'un type de sources encore peu utilisées dans l'histoire de la seconde moitié du 20e siècle, les dossiers médicaux. Ce cadre étant posé, nous procédons à l'analyse des enchaînements entre les certificats, les premiers entretiens cliniques, le récit d'anamnèse, la construction du diagnostic, les indications de traitement, le pronostic, etc., autant d'indices diachroniques qui offrent un lieu d'observation des savoirs et savoir-faire impliqués – ou pas. En effet, il ne s'agit pas tant ici d'évaluer l'impact de certaines doctrines que d'examiner quels sont les signes cliniques et les dichotomies conceptuelles sur lesquels les cliniciens s'appuient, et de questionner l'usage d'outils comme les tests psychologiques. On peut alors dégager le constat que la clinique n'est pas seulement une production de signes objectifs, mais que les symptômes subjectifs font aussi partie des pratiques de santé en psychiatrie, à partir du moment où elle en fait une catégorie normative, intermédiaire entre des conduites atypiques et un diagnostic caractérisé, comme la schizophrénie.
Entre médecine, culture et pensée sociopolitique : le concept de dégénérescence au Québec (1860–1925)
Authors: Collin Johanne , Hughes David
Published: October 2016

La présente étude se penche sur les rapports entre la psychiatrie, la culture et la pensée sociopolitique au Québec. Notre approche s'inspire des travaux de Mark Micale sur le concept d'hystérie en France. Dans The Mind of Modernism, Micale démontre l'omniprésence de l'hystérie dans l'imaginaire collectif français au tournant du siècle. Notre objectif est de déterminer si un concept psychiatrique a pu jouer un rôle semblable au Québec à la même période. Nous démontrons que le concept de dégénérescence a pénétré la nosographie officielle, les publications médicales, les revues, la fiction ainsi que les discours sociopolitiques québécois.
An Evil Hitherto Unchecked: Eugenics and the 1917 Ontario Royal Commission on the Care and Control of the Mentally Defective and Feeble-Minded
Authors: Koester C. Elizabeth
Published: October 2016

In 1917, the Ontario government appointed the Royal Commission on the Care and Control of the Mentally Defective and Feeble-Minded, headed by Justice Frank Hodgins. Its final report made wide-ranging recommendations regarding the segregation of feeble-minded individuals, restrictions on marriage, the improvement of psychiatric facilities, and the reform of the court system, all matters of great concern to the eugenics movement. At the same time, however, it refrained from using explicitly eugenic vocabulary and ignored the question of sterilization. This article explores the role the commission played in the trajectory of eugenics in Ontario (including the province's failure to pass sterilization legislation) and considers why its recommendations were disregarded.
Blood Transfusion and the Body in Early Modern France
Authors: Chin-Yee Benjamin H. , Chin-Yee Ian H.
Published: October 2016

This article examines medical discourse surrounding the first animal-to-human blood transfusion performed in 1667 by the French physician Jean-Baptiste Denis. During this period, new physiologies interacted with Galenic medicine in various social milieus that shaped discourse over the body. Although the practice of transfusion was based in contemporary theories of circulation, the therapeutic rationale for transfusion largely appealed to Galenic humouralism. This case reveals how social and intellectual contexts engendered an eclectic corporality, which integrated contemporary natural philosophy within a framework of medical Galenism. Medical discourse from this episode suggests a pluralistic conception of the body – a body that was broadly humoural but included accretions from new physiologies.
Forced Migration as Public Relations Process? Lothar B. Kalinowsky and the Trans-Atlantic Transfer of Electroconvulsive Therapy
Authors: Stahnisch Frank W.
Published: October 2016

Research in biological psychiatry during the first half of the 20th century was based upon a wide range of interrelated disciplines, including neurology, neuroanatomy, neuropathology, and experimental biology. The work of German-American psychiatrist and neurologist Lothar B. Kalinowsky (1899–1992) is taken here as an example of how such fields could be combined to produce a highly innovative and multidimensional research program in clinical neuroscience. Kalinowsky functioned exceptionally well in both scientific and clinical cultures despite the marked contextual differences between the Charité in Berlin and his later workplace in New York's Columbia Medical School. The innovative ideas exemplified by Kalinowsky's efforts, however, sometimes amounted to a dubious advantage for émigré clinical neuroscientists: they easily led to incommensurable scientific views, and sometimes even resulted in the marginalization of the innovator from existing research programs.
Imagining and Imaging the Social Brain: The Case of Mirror Neurons
Authors: Lanzoni Susan
Published: October 2016

In a contemporary setting in which all things “neuro” have great cultural sway, an analysis of the ways in which neuroscience is indebted to the methods and findings of the social sciences has received less attention. Indeed, in the new specialization of social neuroscience, neuroscientists now collaborate with contemporary psychologists and invoke historical psychological theories to help theorize empathy and social understanding. This article examines the overlap between psychological frameworks of social emotion and neuroscience in the case of mirror neurons, discovered in the 1990s. Some neuroscientists purport that mirror neurons underlie the social behaviours of imitation and empathy, and have found support for this view of theories of simulation and embodied cognition. They have also invoked pragmatic and phenomenological approaches to mind and behaviour dating back to the early 20th century. Neuroscientists have thus imported, adapted, and interpreted psychological models to help define social understanding, empathy, and imitation in many imaging studies.
Posterior-only surgical correction of dystrophic scoliosis in 31 patients with neurofibromatosis Type 1 using the multiple anchor point method
Authors: Deng Ang , Zhang Hong-Qi , Tang Ming-Xing , Liu Shao-Hua , Wang Yu-Xiang , Gao Qi-Le
Published: October 2016

OBJECTIVE

The objective of this study was to evaluate the clinical efficacy of posterior-only surgical correction of dystrophic scoliosis in patients with neurofibromatosis Type 1 (NF1) using a multiple anchor point method (MAPM).

METHODS

From 2005 to 2014, 31 patients (mean age 13.5 years old, range 10–22 years old) suffering from dystrophic scoliosis associated with NF1 underwent posterior-only surgical correction using a MAPM. The apex of the deformity was thoracic (n = 25), thoracolumbar (n = 4), and lumbar (n = 2). The mean preoperative coronal Cobb angle was 69.1° (range 48.9°–91.4°). The mean Cobb angle on the side-bending radiograph of the convex side was 58.2° (range 40°–79.8°). The mean flexibility and apical vertebral rotation (AVR) were 15.6% (range 8.3%–28.2%) and 2.5° (range 2°–3°), respectively. The mean angle of sagittal kyphosis was 58.3° (range 34.1°–79.6°).

RESULTS

The mean follow-up period was 53 months (range 12–96 months). The mean postoperative coronal Cobb angle was 27.4° (range 16.3°–46.7°). Postoperatively, the mean AVR and angle of sagittal kyphosis were 1.2° (range 1°–2°) and 22.4° (range 4.2°–36.3°), respectively. All patients showed good correction of all indices postoperatively. The mean postoperative correction rate was 58.7% (range 46.3%–74.1%). At the final follow-up evaluation, the corrective loss rate of the Cobb angle was only 2.3%. Only 1 patient required revision surgery. No severe complications such as spinal cord, neural, or large vascular injury occurred during the operation.

CONCLUSIONS

Posterior-only surgical correction of dystrophic scoliosis in patients with NF1 using a MAPM could yield satisfactory clinical efficacy of correction and fusion.
Wastewater Treatment in Chinese Rural Areas
Authors: Deng Yihuan , Wheatley Andrew
Published: October 2016

In the last 10 years, the extent of wastewater treated in China has increased by 57%, the great amounts of sewage have threatened people’s health as well the natural environment. In the last 10 years, the sewage treatment rate has improved, in December 2013, 99.1% of Chinese cities and 82.6% counties have sewage treatment plants. This review paper describes the current situation and has suggestion of how to overcome future sewage problems especially water pollution in China from domestic, agriculture and industrial sectors. It also discusses the urban/rural wastewater for treatment including sewerage systems, treatment plants and water quality standards in China. The paper highlights the challenges of effective wastewater treatment in rural areas as a particular issue due to lack of monitoring and law support. This has led to ineffective management of treatment plants, financial difficulties; inappropriate sewerage, treatment facilities and standards; as well as poor awareness.
A Review on the Environmental Pollution of Langat River, Malaysia
Authors: Ahmed Minhaz Farid , Alam Lubna , Ta Goh Choo , Mohamed Che Abd Rahim , Mokhtar Mazlin
Published: October 2016

Environmental pollution of the rivers in terms of floods, droughts and landslides are the outcomes of the uncertain rainfall pattern due to climate change and it also contributes to the chemical contamination of the rivers along with the anthropogenic activities. The Langat River can also be polluted by the trans-boundary floods and precipitation in terms of the air pollution both in Malaysia and in the neighbour countries. Therefore, the water resource management related government and non-government institutes, business sector and civil society should have an effective participation for the better management of the river. Moreover, a regional platform could be useful in order to mitigate the impacts of atmospheric pollution as well as trans-boundary floods through sharing information, knowledge and expertise.
Natural Hematite as a Low-Cost and Earth-Abundant Cathode Material for Performance Improvement of Microbial Fuel Cells
Authors: Ren Guiping , Ding Hongrui , Li Yan , Lu Anhuai
Published: October 2016

Developing cheap electrocatalysts for cathodic oxygen reduction in neutral medium is a key factor for practical applications of microbial fuel cells (MFCs). Natural hematite was investigated as a low-cost cathode to improve the performance of microbial fuel cells (MFCs). With hematite-coated cathode, the cell current density stabilized at 330.66 ± 3.1 mA·m−2 (with a 1000 Ω load) over 10 days under near-neutral conditions. The maximum power density of MFC with hematite cathode reached to 144.4 ± 7.5 mW·m−2, which was 2.2 times that of with graphite cathode (64.8 ± 5.2 mW·m−2). X-ray diffraction (XRD), Raman, electrode potential analysis, and cyclic voltammetry (CV) revealed that hematite maintained the electrode activities due to the stable existence of Fe(II)/Fe(III) in mineral structure. Electrochemical impedance spectroscopy (EIS) results indicated that the cathodic electron transfer dynamics was significantly improved by using hematite to lower the cathodic overpotential. Therefore, this low-cost and earth-abundant natural mineral is promised as an effective cathode material with potential large-field applications of MFCs in future.
Analysis of VIA and EbA in a River Bank Erosion Prone Area of Bangladesh Applying DPSIR Framework
Authors: Rahman Syed , Faisal B. , Rahman Md. , Taher Toiaba
Published: October 2016

This study aims to set up a comprehensive approach to the Vulnerability and Impact Assessment (VIA) of river erosion and to suggest Ecosystem-based Adaptation (EbA) practices. Based on the analysis of vulnerability using the Driver-Pressure-State-Impact-Response (DPSIR) framework, this paper discusses some of the significant climatic (rainfall pattern, temperature, seasonal drift, cold wave and heat wave) and non-climatic (river erosion, repetitive death of field crops and agrochemicals) forces in the Kazipur Upazila (Sirajganj District)—a river erosion-prone area of Bangladesh. Both primary (Key Informants Interview, Household Survey, and Focus Group Discussion) and secondary (climatic, literature review) data have been used in revealing the scenario of climatic stress. The analysis revealed a slightly increasing trend of mean annual temperature, and a decreasing trend of total annual rainfall from 1981 to 2015, which have been supported by people’s perception. This study found that river erosion, the increase of temperature and the late arrival of monsoon rain, excessive monsoon rainfall, high use of agrochemicals, and flow alterations are major drivers in the riverine ecosystem. These drivers are creating pressures on agricultural land, soil fertility, water availability and livelihood patterns of affected communities. Hence, floating bed cultivation, integrated pest management, use of cover crops, reforestation, the introduction of an agro-weather forecasting system, and a new variety of flood tolerant species have been suggested as potential EbA to cope with river bank erosion and to increase the capacity of the affected ecosystem.
A Multi-Slope Sliding-Mode Control Approach for Single-Phase Inverters under Different Loads
Authors: Khajeh-Shalaly Babak , Shahgholian Ghazanfar
Published: October 2016

In this paper, a new approach to the sliding-mode control of single-phase inverters under linear and non-linear loads is introduced. The main idea behind this approach is to utilize a non-linear, flexible and multi-slope function in controller structure. This non-linear function makes the controller possible to control the inverter by a non-linear multi-slope sliding surface. In general, this sliding surface has two parts with different slopes in each part and the flexibility of the sliding surface makes the multi-slope sliding-mode controller (MSSMC) possible to reduce the total harmonic distortion, to improve the tracking accuracy, and to prevent overshoots leading to undesirable transient-states in output voltage that occur when the load current sharply rises. In order to improve the tracking accuracy and to reduce the steady-state error, an integral term of the multi-slope function is also added to the sliding surface. The improved performance of the proposed controller is confirmed by simulations and finally, the results of the proposed approach are compared with a conventional sliding-mode controller (SMC) and a synchronous reference frame PI (SRFPI) controller.
Polylactic Acid Improves the Rheological Properties, and Promotes the Degradation of Sodium Carboxymethyl Cellulose-Modified Alkali-Activated Cement
Authors: Tan Huijing , Zheng Xiuhua , Duan Chenyang , Xia Bairu
Published: October 2016

In consideration of the insolubility in water, sensitivity to heat and wide application in the oil and gas industry as a degradable additive, this paper introduces polylactic acid (PLA) to a self-degradable temporary sealing material (SDTSM) to investigate its effect on the SDTSM performance and evaluate its potential to improve the rheological properties and further promote the self-degradation of the material. The thermal degradation of PLA, the rheological properties, compressive strength, hydrated products and water absorption of SDTSMs with different PLA dosages were tested. The analysis showed that the addition of 2% PLA increased the fluidity by 13.18% and reduced the plastic viscosity by 38.04%, when compared to those of the SDTSM without PLA. PLA increased the water absorption of 200 °C-heated SDTSM and had small effect on the types but decreased the hydrate products of 85 °C-cured SDTSM, and created plenty of pores in 200 °C-heated SDTSM. PLA enhanced the self-degradation level of SDTSM by generating a large amount of pores in cement. These pores worked in two ways: one was such a large amount of pores led to a looser microstructure; the other was these pores made the water impregnate the cement more easily, and then made the dissolution of substances in the 200 °C-heated SDTSM progress faster to generate heat and to destruct the microstructure.
Partitioning Tree Species Diversity and Developmental Changes in Habitat Associations in a Subtropical Evergreen Broadleaf Secondary Forest in Southern China
Authors: Cui Wei , Zheng Xiao-Xian
Published: October 2016

The classical environmental control model assumes that species diversity is primarily determined by environmental conditions (e.g., microclimate and soil) on the local scale. This assumption has been challenged by the neutral theory that assumes that the maintenance of biodiversity mainly depends on the ecological drift and dispersal limitation. Understanding the mechanisms that maintain biodiversity depends on decomposing the variation of species diversity into the contributions from the various components that affect it. We investigated and partitioned the effects of the biotic component (productivity, forest spatial structure) and the environmental component (topography and soil fertility) on the distribution of tree species richness jointly (the combined effect of environment and biotic process) and separately (the effect of environment or biotic process alone) in 25 permanent plots of 600 m2 in a subtropical evergreen broadleaf secondary forest in southern China. The analysis was also completed for trees at different growth stages based on diameter breast height (young trees: 5 cm ≤ DBH < 10 cm, mature trees: 10 cm < DBH ≤ 20 cm, old trees: DBH > 20 cm) within each plot. Our results indicated that (1) tree species richness had significant negative relationship with productivity and a unimodal relationship with its spatially structured distribution; (2) biotic and environmental factors both have significant influence on species richness and jointly explain ~60% of the variation for the overall tree assemblage, and the variation explained by the two components jointly increased across growth stages (34%, 44%, and 75%, respectively); (3) additive variation partitioning revealed that the tree species richness was dominantly controlled by environmental factors (32%), while the biotic component also independently contributed a non-negligible effect (16%); and (4) the dominant fraction changed from the biotic component to the environmental component across growth stages. Results suggest that the tree species richness may be governed from neutral process to environmental control during tree life span in subtropical evergreen broadleaf secondary forests.
The Dynamic Trend of Soil Water Content in Artificial Forests on the Loess Plateau, China
Authors: Wang Yu , Zhu Qing-Ke , Zhao Wei-Jun , Ma Huan , Wang Rui , Ai Ning
Published: October 2016

Extensive vegetation restoration projects have been widely implemented on the Loess Plateau, China, since 1998. In addition, increasing attention has been paid to the influence of revegetation on soil water. However, the response of the soil water content (SWC) to vegetation construction and management has not been adequately studied. In this study, three types of typical artificial vegetation on level bench land were selected, including Pinus tabulaeformis Carr., Prunus sibirica L., and Hippophae rhamnoides Linn., with the natural grassland used as a control group in Wuqi County. The 0–160 cm SWC was monitored biweekly from August 2010 to June 2013 using a portable time domain reflectometry system. The serial autocorrelation test, Mann–Kendall trend test, and prewhitening Mann–Kendall test were employed to systematically analyze the trends in soil water dynamics. The results show that the SWC of the three selected artificial forests/shrub had a significant accumulation process in the 0–160 cm profile during the monitoring period, whereas such an increasing tendency was not observed for natural grassland. Furthermore, the greatest responses were observed in the Pinus tabulaeformis Carr. plantation.
Effects of Lane Width, Lane Position and Edge Shoulder Width on Driving Behavior in Underground Urban Expressways: A Driving Simulator Study
Authors: Liu Shuo , Wang Junhua , Fu Ting
Published: October 2016

This study tested the effects of lane width, lane position and edge shoulder width on driving behavior for a three-lane underground urban expressway. A driving simulator was used with 24 volunteer test subjects. Five lane widths (2.85, 3.00, 3.25, 3.50, and 3.75 m) and three shoulder widths (0.50, 0.75, and 1.00 m) were studied. Driving speed, lane deviation and subjective perception of driving behavior were collected as performance measures. The results show that lane and shoulder width have significant effects on driving speed. Average driving speed increases from 60.01 km/h in the narrowest lane to 88.05 km/h in the widest lane. While both narrower lanes and shoulders result in reduced speed and lateral lane deviation, the effect of lane width is greater than that of shoulder width. When the lane and shoulder are narrow, drivers in the left or right lane tend to shy away from the tunnel wall, even encroaching into the neighboring middle lane. As the lane or shoulder gets wider, drivers tend to stay in the middle of the lane. An interesting finding is that although few participants acknowledged that lane position had any great bearing on their driving behaviors, the observed driving speed is statistically higher in the left lane than in the other two lanes when the lane width is narrow (in 2.85, 3 and 3.25 m lanes). These findings provided support for amending the current design specifications of urban underground roads, such as the relationship between design speed and lane width, speed limit, and combination form of lanes.
Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer
Authors: Verde Zoraida , Santiago Catalina , Chicharro Luis , Reinoso-Barbero Luis , Tejerina Alejandro , Bandrés Fernando , Gómez-Gallego Félix
Published: October 2016

Introduction: Tobacco smoke contains many potentially harmful compounds that may act differently and at different stages in breast cancer development. The focus of this work was to assess the possible role of cigarette smoking (status, dose, duration or age at initiation) and polymorphisms in genes coding for enzymes involved in tobacco carcinogen metabolism (CYP1A1, CYP2A6) or in DNA repair (XRCC1, APEX1, XRCC3 and XPD) in breast cancer development. Methods: We designed a case control study with 297 patients, 217 histologically verified breast cancers (141 smokers and 76 non-smokers) and 80 healthy smokers in a cohort of Spanish women. Results: We found an association between smoking status and early age at diagnosis of breast cancer. Among smokers, invasive carcinoma subtype incidence increased with intensity and duration of smoking (all Ptrend < 0.05). When smokers were stratified by smoking duration, we only observed differences in long-term smokers, and the CYP1A1 Ile462Ile genotype was associated with increased risk of breast cancer (OR = 7.12 (1.98–25.59)). Conclusions: Our results support the main effect of CYP1A1 in estrogenic metabolism rather than in tobacco carcinogen activation in breast cancer patients and also confirmed the hypothesis that CYP1A1 Ile462Val, in association with long periods of active smoking, could be a breast cancer risk factor.
Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1
Authors: Singh Warispreet , Fields Gregg , Christov Christo , Karabencheva-Christova Tatyana
Published: October 2016

Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and conformational effects of such mutations, a molecular dynamics (MD) study was performed of in silico mutated residues in the X-ray crystallographic structure of MMP-1 complexed with a collagen-model triple-helical peptide (THP). The results indicate an important role of the mutated residues in MMP-1 interactions with the THP and communication between the CAT and the HPX domains. Each mutation has a distinct impact on the correlated motions in the MMP-1•THP. An increased collagenase activity corresponded to the appearance of a unique anti-correlated motion and decreased correlated motions, while decreased collagenase activity corresponded both to increased and decreased anti-correlated motions.
Rare Earth and Actinide Complexes
Authors: Mansell Stephen , Liddle Stephen
Published: October 2016

The rare earth metals (scandium, yttrium, lanthanum and the subsequent 4f elements) and actinides (actinium and the 5f elements) are vital components of our technology-dominated society.[...]
Label-Free Differential Proteomics and Quantification of Exoenzymes from Isolates of the Entomopathogenic Fungus Beauveria bassiana
Authors: Dionisio Giuseppe , Kryger Per , Steenberg Tove
Published: October 2016

Beauveria bassiana is an entomopathogenic fungus that grows both in vivo and in vitro. In vivo it can colonize live insect hosts, and tissue digestion occurs by secreted hydrolytic exoenzymes. It can also colonize dead insect tissue provided this is free from competing microorganisms. Depending on whether the host is alive or dead the expression (quality/quantity) of the exoenzymes may vary. We have grown several isolates of B. bassiana in shaking flasks for 120 h at 25 °C in order to evaluate the maximal exoenzyme production using two diet regimes. As sole carbon, nitrogen, and phosphate sources we used 1% shrimp chitin and either 0.5% w/v of dead intact American cockroach (Periplaneta americana) or their isolated cuticles. This is the first report of a differential proteomics of B. bassiana exoenzymes performed by label-free nano-LC MS/MS. Total proteolytic enzyme activity was mainly due to Pr1A or Pr1B depending on the isolate and the diet regime. The most differentially secreted enzymes were: the cuticle-degrading subtilisin Pr1A, GH13 alpha-glycosidase, glucan endo-1,3-beta-glucosidase, subtilisin-like proteinase Spm1, lipase 1, beta-1,3 exoglucanase, and endo-1,3-beta-glucosidase. Among the B. bassiana isolates analyzed, Bb 678 and Bb BG were the most active in Pr1A secretion.
A Constitutive Relationship between Fatigue Limit and Microstructure in Nanostructured Bainitic Steels
Authors: Mueller Inga , Rementeria Rosalia , Caballero Francisca , Kuntz Matthias , Sourmail Thomas , Kerscher Eberhard
Published: October 2016

The recently developed nanobainitic steels show high strength as well as high ductility. Although this combination seems to be promising for fatigue design, fatigue properties of nanostructured bainitic steels are often surprisingly low. To improve the fatigue behavior, an understanding of the correlation between the nanobainitic microstructure and the fatigue limit is fundamental. Therefore, our hypothesis to predict the fatigue limit was that the main function of the microstructure is not necessarily totally avoiding the initiation of a fatigue crack, but the microstructure has to increase the ability to decelerate or to stop a growing fatigue crack. Thus, the key to understanding the fatigue behavior of nanostructured bainite is to understand the role of the microstructural features that could act as barriers for growing fatigue cracks. To prove this hypothesis, we carried out fatigue tests, crack growth experiments, and correlated these results to the size of microstructural features gained from microstructural analysis by light optical microscope and EBSD-measurements. Finally, we were able to identify microstructural features that influence the fatigue crack growth and the fatigue limit of nanostructured bainitic steels.
Evolution Law of Helium Bubbles in Hastelloy N Alloy on Post-Irradiation Annealing Conditions
Authors: Gao Jie , Bao Liangman , Huang Hefei , Li Yan , Zeng Jianrong , Liu Zhe , Liu Renduo , Shi Liqun
Published: October 2016

This work reports on the evolution law of helium bubbles in Hastelloy N alloy on post-irradiation annealing conditions. After helium ion irradiation at room temperature and subsequent annealing at 600 °C (1 h), the transmission electron microscopy (TEM) micrograph indicates the presence of helium bubbles with size of 2 nm in the depth range of 0–300 nm. As for the sample further annealed at 850 °C (5 h), on one hand, a “Denuded Zone” (0–38 nm) with rare helium bubbles forms due to the decreased helium concentration. On the other hand, the “Ripening Zone” (38–108 nm) and “Coalescence Zone” (108–350 nm) with huge differences in size and separation of helium bubbles, caused by different coarsening rates, are observed. The mechanisms of “Ostwald ripening” and “migration and coalescence”, experimentally proved in this work, may explain these observations.
An Assessment of the Mechanical Properties and Microstructural Analysis of Dissimilar Material Welded Joint between Alloy 617 and 12Cr Steel
Authors: Ahmad Hafiz , Hwang Jeong , Lee Ju , Bae Dong
Published: October 2016

The most effective method to reduce CO2 gas emission from the steam power plant is to improve its performance by elevating the steam temperature to more than 700 °C. For this, it is necessary to develop applicable materials at high temperatures. Ni-based Alloy 617 and 12Cr steel are used in steam power plants, due to their remarkable mechanical properties, high corrosion resistance, and creep strength. However, since Alloy 617 and 12Cr steel have different chemical compositions and thermal and mechanical properties, it is necessary to develop dissimilar material welding technologies. Moreover, in order to guarantee the reliability of dissimilar material welded structures, the assessment of mechanical and metallurgical properties, fatigue strength, fracture mechanical analysis, and welding residual stress analysis should be conducted on dissimilar material welded joints. In this study, first, multi-pass dissimilar material welding between Alloy 617 and 12Cr steel was performed under optimum welding conditions. Next, mechanical properties were assessed, including the static tensile strength, hardness distribution, and microstructural analysis of a dissimilar material welded joint. The results indicated that the yield strength and tensile strength of the dissimilar metal welded joint were higher than those of the Alloy 617 base metal, and lower than those of the 12Cr steel base metal. The hardness distribution of the 12Cr steel side was higher than that of Alloy 617 and the dissimilar material weld metal zone. It was observed that the microstructure of Alloy 617 HAZ was irregular austenite grain, while that of 12Cr steel HAZ was collapsed martensite grain, due to repeatable heat input during multi-pass welding.
Design Optimization and Fabrication of High-Sensitivity SOI Pressure Sensors with High Signal-to-Noise Ratios Based on Silicon Nanowire Piezoresistors
Authors: Zhang Jiahong , Zhao Yang , Ge Yixian , Li Min , Yang Lijuan , Mao Xiaoli
Published: October 2016

In order to meet the requirement of high sensitivity and signal-to-noise ratios (SNR), this study develops and optimizes a piezoresistive pressure sensor by using double silicon nanowire (SiNW) as the piezoresistive sensing element. First of all, ANSYS finite element method and voltage noise models are adopted to optimize the sensor size and the sensor output (such as sensitivity, voltage noise and SNR). As a result, the sensor of the released double SiNW has 1.2 times more sensitivity than that of single SiNW sensor, which is consistent with the experimental result. Our result also displays that both the sensitivity and SNR are closely related to the geometry parameters of SiNW and its doping concentration. To achieve high performance, a p-type implantation of 5 × 1018 cm−3 and geometry of 10 µm long SiNW piezoresistor of 1400 nm × 100 nm cross area and 6 µm thick diaphragm of 200 µm × 200 µm are required. Then, the proposed SiNW pressure sensor is fabricated by using the standard complementary metal-oxide-semiconductor (CMOS) lithography process as well as wet-etch release process. This SiNW pressure sensor produces a change in the voltage output when the external pressure is applied. The involved experimental results show that the pressure sensor has a high sensitivity of 495 mV/V·MPa in the range of 0–100 kPa. Nevertheless, the performance of the pressure sensor is influenced by the temperature drift. Finally, for the sake of obtaining accurate and complete information over wide temperature and pressure ranges, the data fusion technique is proposed based on the back-propagation (BP) neural network, which is improved by the particle swarm optimization (PSO) algorithm. The particle swarm optimization–back-propagation (PSO–BP) model is implemented in hardware using a 32-bit STMicroelectronics (STM32) microcontroller. The results of calibration and test experiments clearly prove that the PSO–BP neural network can be effectively applied to minimize sensor errors derived from temperature drift.
Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts
Authors: Li Pan , Hu Xinquan , Dong Xiu-Qin , Zhang Xumu
Published: October 2016

The organocatalysis-based dynamic kinetic resolution (DKR) process has proved to be a powerful strategy for the construction of chiral compounds. In this feature review, we summarized recent progress on the DKR process, which was promoted by chiral bifunctional (thio)urea and squaramide catalysis via hydrogen-bonding interactions between substrates and catalysts. A wide range of asymmetric reactions involving DKR, such as asymmetric alcoholysis of azlactones, asymmetric Michael–Michael cascade reaction, and enantioselective selenocyclization, are reviewed and demonstrate the efficiency of this strategy. The (thio)urea and squaramide catalysts with dual activation would be efficient for more unmet challenges in dynamic kinetic resolution.
Triboelectric Hydrogen Gas Sensor with Pd Functionalized Surface
Authors: Shin Sung-Ho , Kwon Yang , Kim Young-Hwan , Jung Joo-Yun , Nah Junghyo
Published: October 2016

Palladium (Pd)-based hydrogen (H2) gas sensors have been widely investigated thanks to its fast reaction and high sensitivity to hydrogen. Various sensing mechanisms have been adopted for H2 gas sensors; however, all the sensors must be powered through an external battery. We report here an H2 gas sensor that can detect H2 by measuring the output voltages generated during contact electrification between two friction surfaces. When the H2 sensor, composed of Pd-coated ITO (indium tin oxide) and PET (polyethylene Terephthalate) film, is exposed to H2, its output voltage is varied in proportion to H2 concentration because the work function (WF) of Pd-coated surface changes, altering triboelectric charging behavior. Specifically, the output voltage of the sensor is gradually increased as exposing H2 concentration increases. Reproducible and sensitive sensor response was observed up 1% H2 exposure. The approach introduced here can easily be adopted to development of triboelectric gas sensors detecting other gas species.
Highly Branched Bio-Based Unsaturated Polyesters by Enzymatic Polymerization
Authors: Nguyen Hiep , Löf David , Hvilsted Søren , Daugaard Anders
Published: October 2016

A one-pot, enzyme-catalyzed bulk polymerization method for direct production of highly branched polyesters has been developed as an alternative to currently used industrial procedures. Bio-based feed components in the form of glycerol, pentaerythritol, azelaic acid, and tall oil fatty acid (TOFA) were polymerized using an immobilized Candida antarctica lipase B (CALB) and the potential for an enzymatic synthesis of alkyds was investigated. The developed method enables the use of both glycerol and also pentaerythritol (for the first time) as the alcohol source and was found to be very robust. This allows simple variations in the molar mass and structure of the polyester without premature gelation, thus enabling easy tailoring of the branched polyester structure. The postpolymerization crosslinking of the polyesters illustrates their potential as binders in alkyds. The formed films had good UV stability, very high water contact angles of up to 141° and a glass transition temperature that could be controlled through the feed composition.
An Examination of Batteries Remaining in Used Electric and Electronic Devices: Insights Gained from a Transdisciplinary Project
Authors: Friege Henning , Reutter Leo , Gnutzmann Nele , Klöffer Amélie , Mohrlok Moritz , De la Sauce Aline , Wons Wilhelm , Kross Sebastian
Published: October 2016

The volume of batteries, especially high-energy batteries, in electric and electronic devices is increasing. They are mainly used in small electric and electronic devices, e.g., mobile phones, laptops, household equipment, and tools. With regard to WEEE, these batteries will either remain in the used appliances or be removed by their users for separate collection. Batteries must be removed at the latest during dismantling in order to avoid loss or damage when WEEE is shredded. A representative sample of 2 mg of small WEEE was collected from take-back points in a German city in order to obtain an impression of consumer behavior. The batteries not removed from used electric and electronic appliances submitted by their owners were examined with regard to their type and condition, i.e., whether they were damaged or not. About 20% of all WEEE ran either completely or partially on batteries. Almost half of the batteries had been removed before the used electronic appliances were submitted at the take-back points. By contrast to standard batteries, the volume of special batteries (mainly Li ion or NiCd accumulators) remaining in the appliances amounted to about 75%. Some further conclusions on the way consumers handle batteries could be drawn from the results.
Selectivity Enhancement in Molecularly Imprinted Polymers for Binding of Bisphenol A
Authors: Alenazi Noof , Manthorpe Jeffrey , Lai Edward
Published: October 2016

Bisphenol A (BPA) is an estrogen-mimicking chemical that can be selectively detected in water using a chemical sensor based on molecularly imprinted polymers (MIPs). However, the utility of BPA-MIPs in sensor applications is limited by the presence of non-specific binding sites. This study explored a dual approach to eliminating these sites: optimizing the molar ratio of the template (bisphenol A) to functional monomer (methacrylic acid) to cross-linker (ethylene glycol dimethacrylate), and esterifying the carboxylic acid residues outside of specific binding sites by treatment with diazomethane. The binding selectivity of treated MIPs and non-treated MIPs for BPA and several potential interferents was compared by capillary electrophoresis with ultraviolet detection. Baclofen, diclofenac and metformin were demonstrated to be good model interferents to test all MIPs for selective binding of BPA. Treated MIPs demonstrated a significant decrease in binding of the interferents while offering high selectivity toward BPA. These results demonstrate that conventional optimization of the molar ratio, together with advanced esterification of non-specific binding sites, effectively minimizes the residual binding of interferents with MIPs to facilitate BPA sensing.
Banishment in Public Housing: Testing an Evolution of Broken Windows
Authors: Torres Jose , Apkarian Jacob , Hawdon James
Published: October 2016

Banishment policies grant police the authority to formally ban individuals from entering public housing and arrest them for trespassing if they violate the ban. Despite its widespread use and the social consequences resulting from it, an empirical evaluation of the effectiveness of banishment has not been performed. Understanding banishment enforcement is an evolution of broken windows policing, this study explores how effective bans are at reducing crime in public housing. We analyze crime data, spanning the years 2001–2012, from six public housing communities and 13 surrounding communities in one southeastern U.S. city. Using Arellano-Bond dynamic panel models, we investigate whether or not issuing bans predicts reductions in property and violent crimes as well as increases in drug and trespass arrests in public housing. We find that this brand of broken windows policing does reduce crime, albeit relatively small reductions and only for property crime, while resulting in an increase in trespass arrests. Given our findings that these policies have only a modest impact on property crime, yet produce relatively larger increases in arrests for minor offenses in communities of color, and ultimately have no significant impact on violent crime, it will be important for police, communities, and policy makers to discuss whether the returns are worth the potential costs.
Sustainable Mobility: Longitudinal Analysis of Built Environment on Transit Ridership
Authors: Kim Dohyung , Ahn Yongjin , Choi Simon , Kim Kwangkoo
Published: October 2016

Given the concerns about urban mobility, traffic congestion, and greenhouse gas (GHG) emissions, extensive research has explored the relationship between the built environment and transit ridership. However, the nature of aggregation and the cross-sectional approach of the research rarely provide essential clues on the potential of a transit system as a sustainable mobility option. From the perspective of longitudinal sustainability, this paper develops regression models for rail transit stations in the Los Angeles Metro system. These models attempt to identify the socio-demographic characteristics and land use features influencing longitudinal transit ridership changes. Step-wise ordinary least square (OLS) regression models are used to identify factors that contribute to transit ridership changes. Those factors include the number of dwelling units, employment-oriented land uses such as office and commercial land uses, and land use balance. The models suggest a negative relationship between job and population balance with transit ridership change. They also raise a question regarding the 0.4 km radius commonly used in transit analysis. The models indicate that the 0.4 km radius is too small to capture the significant influence of the built environment on transit ridership.
Evaluation of Radiation Components in a Global Freshwater Model with Station-Based Observations
Authors: Müller Schmied Hannes , Müller Richard , Sanchez-Lorenzo Arturo , Ahrens Bodo , Wild Martin
Published: October 2016

In many hydrological models, the amount of evapotranspired water is calculated using the potential evapotranspiration (PET) approach. The main driver of several PET approaches is net radiation, whose downward components are usually obtained from meteorological input data, whereas the upward components are calculated by the model itself. Thus, uncertainties can be large due to both the input data and model assumptions. In this study, we compare the radiation components of the WaterGAP Global Hydrology Model, driven by two meteorological input datasets and two radiation setups from ERA-Interim reanalysis. We assess the performance with respect to monthly observations provided by the Baseline Surface Radiation Network (BSRN) and the Global Energy Balance Archive (GEBA). The assessment is done for the global land area and specifically for energy/water limited regions. The results indicate that there is no optimal radiation input throughout the model variants, but standard meteorological input datasets perform better than those directly obtained by ERA-Interim reanalysis for the key variable net radiation. The low number of observations for some radiation components, as well as the scale mismatch between station observations and 0.5° × 0.5° grid cell size, limits the assessment.