bluuebunny/crossref_metadata_2025 huggingface dataset:
KONOPLJA V MEDICINI: otroška nevrologija
Authors: Neubauer David , Perkovič-Benedik Mirjana
Published: September 2023

Epilepsija (sinonim tudi božjast) prizadene približno en odstotek prebivalstva po vsem svetu. Otroška epilepsija, ki se pojavi pred tretjim letom starosti in ima trdovratne epileptične napade (napadi odporni na različna protiepileptična zdravila – PEZ), je lahko v mnogih primerih povezana z zmanjšanim inteligenčnim količnikom v poznejšem otroškem in mladostniškem obdobju (1). Taka epilepsija ne botruje zgolj zmanjšanju kognitivnih funkcij pač pa tudi pogostim vedenjskim in psihiatričnim motnjam, ki se lahko pokažejo šele v mladostniškem obdobju (2,3). Zato so v tem zgodnjem in tako ranljivem obdobju otroštva (sprva zlasti glede gibalnega razvoja samega, nato pa predvsem razvoja socialnih in mentalnih veščin) tako pomembni zgodnja prepoznava, pravilno ukrepanje in zdravljenje epileptičnih napadov, ki so odporni na različna PEZ (farmakorezistentni). Končni cilje celotne obravnave otroške epilepsije mora zato vselej biti popolna odsotnost epileptičnih napadov, oziroma čim boljša kontrola epileptičnih napadov, pri čemer pa nas tudi tedaj, ko kot otroški nevrologi menimo, da je možnost ozdravitve majhna, takšno stališče ne sme privesti do tega, da ne poskusimo uporabiti prav vse načine zdravljenja, ki so danes na voljo (3-5).epilepsija
Proces wychodzenia Rosji z systemu Rady Europy
Authors: Krupińska Karolina
Published: September 2023

Członkostwo Federacji Rosyjskiej w Radzie Europy od początku budziło liczne kontrowersje. Niejednokrotnie Rosja była zawieszana w prawach członka Rady Europy w związku z licznymi naruszeniami fundamentalnych praw człowieka i spekulowano na temat wykluczenia Rosji z organizacji. Bezpośrednią przyczyną wyjścia Rosji z systemu Rady Europy okazała się być zbrojna agresja wobec Ukrainy, jednakże można zauważyć, że proces ten był długotrwały. W niniejszym artykule zostanie przedstawione ponad 25-letnie członkostwo Rosji w Radzie Europy. W pierwszej kolejności będzie to historia członkostwa Rosji w Radzie Europy, następnie zostanie zaprezentowane stanowisko Rosji jako strony Europejskiej Konwencji Praw Człowieka, omówienie wybranych naruszeń praw człowieka podczas konfliktów zbrojnych, przyczyny historyczne, które wpłynęły na wyjście Federacji Rosyjskiej z Rady Europy oraz reformę systemu prawa w Rosji.
Metagenomics and Its Tools and Softwares
Authors: Bhati Jyotika , Prabha Ratna , Mishra Dwijesh Chandra
Published: September 2023

Background: Throughout all of nature, microorganisms can be found thriving in a variety of environmental circumstances. Most marine life is either unculturable or challenging to culture using conventional techniques. Methods: Through the analysis of genomic data obtained directly from an environmental sample, metagenomics enables the study of all microorganisms, regardless of whether they can be cultured or not. This allows for the identification of the species present as well as the extraction of knowledge about the functionality of microbial communities in their natural habitat. Result: This article summarizes the state-of-the-art metagenomic approaches used and their associated softwares and tools. In order to comprehend and utilise unculturable microorganisms, metagenomics provides access to the enormous diversity of the microbial world and has significantly advanced both academic communities and industrial settings.
Prenatal Tests Undergone by Moslem Women who Live with an Abnormal Child Compared to Women who Live with Normal Child
Authors: Amiel Aliza , Tarabeih Mahdi
Published: September 2023

Objective: To determine whether Moslem women with an abnormal child at home perform more prenatal tests and pregnancy termination compared to Moslem women who had only a normal child at home. Study Methods: Moslem women (704) participated; 67% (470) lived at home with an abnormal child; 33% (234) only with a normal child. Of the women with an abnormal child, 50% lived in the cities, 47% were nonreligious, 49% had no academic education, and most (95%) had experienced a natural pregnancy. Of the women with a normal child, 49% lived in the cities, 44% were religious, and 50% had no academic education, most (80%) experienced a nonspontaneous pregnancy. Ages: 18-42 (mean 31). Results: Most women with an abnormal child experienced spontaneous pregnancy; however, only 8% were aware of an abnormal fetus. Women with a normal child had experienced a nonspontaneous pregnancy (80%), however, most (97%) had undergone prenatal testing and chose to terminate the pregnancy (p<0.001) due to an abnormality. Conclusion: Moslem women who live at home with a normal child, performed significantly more prenatal tests and terminated most pregnancies when diagnosed with an abnormal fetus, compared to women who lived with an abnormal child. Most of the women with a normal child experienced a non-spontaneous pregnancy which could explain why they received more counseling relating to existing prenatal tests.
Torsion of an Ovarian Endometrioma: About an Uncommon Case Report
Authors: Slaoui Aziz , Mahtate Mariam , Lakhder Khawla , Zeraidi Najia , Lakhdar Amina , Kharbach Aicha , Baydada Aziz
Published: September 2023

Endometrioma, when its size is ≥ 5 cm, can be complicated by a torsion of the ovary. In this case it is a diagnostic and therapeutic emergency with respect to the many complications of ovarian torsion including necrosis. We report a case of endometrioma diagnosed by a torsion of the ovary. The context clinic was dominated by acute pelvic pain; the ultrasound showed a huge left cystic ovary, and the laparotomy revealed a torsion of the left adnexa. A detorsion and cystectomy was performed and the confirmation of the endometrioma was provided by the histology of the surgical specimen. The difficulty lies in the diagnostic and therapeutic choice to preserve or not the ovary. The indications are therefore discussed on a case-by-case basis and depend on many parameters, the most important of which is the intraoperative viability of the ovary after its detorsion.
Multiculturalidad a través del jingle publicitario. Análisis comparativo entre el gobierno del Perú y Claro
Authors:   , Cárdenas Fedalto Yuri Christopher
Published: September 2023

El presente trabajo de investigación analiza las formas de representación discursiva de la multiculturalidad a través del jingle publicitario durante el contexto de las celebraciones del Bicentenario del Perú desde un estudio comparativo entre la promoción comercial y estatal. A pesar de tener el mismo objetivo, “¡#HoyDiaTeCanto, Perú!” de Claro y “Si nos unimos” del Gobierno del Perú, pertenecen a dos perspectivas diferentes en la publicidad (comercial y estatal respectivamente). Esta disparidad es útil para analizar cómo fue representada la multiculturalidad a través de la música por cada caso. El enfoque empleado es cualitativo enmarcado en un paradigma interpretativo. Se utilizó como técnica el análisis de contenido para interpretar de qué forma funcionan los componentes semánticos del jingle y las formas de representación multicultural a través de este. En la investigación se compararon los jingles publicitarios de Claro y del Gobierno, encontrando similitudes en cómo abordan la multiculturalidad, pero diferencias en el aspecto musical y semántico que caracteriza discursos individualistas y colectivistas. Los hallazgos amplían el conocimiento sobre las diferencias y similitudes entre la publicidad pública y privada desde el análisis del discurso musical.
SOSYAL MEDYADA YALAN HABERLE MÜCADELE: KAHRAMANMARAŞ DEPREM HABERLERİNİN TEYİT.ORG ÜZERİNDEN İNCELENMESİ
Authors: COŞKUN Aziz
Published: September 2023

Dijital iletişim dünyasında bilgi akışının hızlanmasına bağlı olarak yalan haberle mücadele önemli bir gereksinimdir. Yalan haber, izleyici/okuyucu kitlesinin gerçek olaylar ve ifadeler hakkındaki düşüncelerini manipüle etmek amacıyla kasıtlı olarak hazırlanmış haber metinleri olarak tanımlanabilir. Yalan haberle mücadele edilmesinde doğruluk kontrolünü yapan sitelere büyük bir görev düşmektedir. Doğruluk kontrolü, doğruluğundan şüphe edilen bilgilerin açık kaynaklar ve sistematik bir yöntem ile kanıtlanması ya da çürütülmesidir. Teyit.org da doğruluk kontrolü yapan web sitelerinden biridir. Bu çalışmanın amacı, 6 Şubat 2023 tarihli Kahramanmaraş merkezli depremler sonrasında sosyal medyada dolaşıma giren yalan ve uydurma haberlerin neler olduğunu tespit etmektir. Bu amaçla teyit.org web sitesinde deprem konulu yalan ve uydurma içerikli haberler, 06.02.023-06.04.2023 tarihleri arasında iki ay boyunca incelenmiştir. İncelemeler, elde edilen verilerin daha önceden belirlenmiş temalar altında özetlenmesi ve yorumlanması mantığına dayanan betimsel içerik analizi ile gerçekleştirilmiştir. Analizlerden elde edilen bulgular, Claire Wardle tarafından oluşturulan kategorilere uygun olarak yorumlanmıştır. Sonuç olarak depremin ilk gününden itibaren birbirinden farklı amaçlarla sosyal medyada birçok yalan ve uydurma haberin bilerek ya da bilmeyerek dolaşıma sokulduğu tespit edilmiştir.
Crimes’ forensic characteristics features in the computer information field
Authors: Kiselev Alexander S. , Gorbunova Ksenia A.
Published: September 2023

The purpose of the research is to identify the main crimes’ forensic characteristics features in the computer information field, inasmuch it makes a great importance in the modern world, as computer crimes are becoming more widespread and threaten the information security, critical infrastructure, personal life and citizens’ finances, organizations and the entire state. The terminological apparatus is analyzed, the classifications of modern cybercriminals are studied, the main approaches to the commission of crimes in the field of computer information are determined. The following methods are used in the research: analysis and synthesis, induction and deduction, system method, dialectical and materialistic methods, formal legal method. The study and analysis of the forensic characteristics allows us to determine the most common ways of committing such crimes, to develop effective counteraction measures. It is established that the main difficulty in the investigation of these crimes is the complex technological nature and the order of their commission. Many criminals are constantly improving their skills, the most qualified of them try to be careful, develop their own countermeasures against law enforcement agencies, using ciphers, special remote access programs to make it as difficult as possible to collect evidence and search activities. Among other things, the difficulty of cybercriminals holding liable is complicated if intruders are located in another state, and unfortunately, one cannot count on international cooperation in the field of law and order and public security with many Western countries today.
Museu da Secretaria de Administração Penitenciária
Authors: Rocco Pietro Ferreti
Published: September 2023

A criação do Museu Penitenciário Paulista no final da década de 1930 foi fortemente influenciada pelas correntes científicas do determinismo biológico existentes na época. Após o declínio dessas concepções que instigaram a criação do museu, ele caiu em ostracismo até ser reformulado e ganhar um novo espaço físico em 2014. Atualmente, suas funções não são mais as mesmas; todavia, parte do pensamento original permanece viva em suas exposições análoga a uma visão institucionalizada do órgão que o administra. O intuito deste artigo é investigar quais os discursos contidos no museu, como se articulam uns com os outros e com as pessoas que afirma representar. Com o auxílio de pesquisas que constituem uma genealogia do sistema penitenciário paulista e que se debruçam sobre os poderes que emanam desses meios, este estudo prioriza o reconhecimento das diversas fronteiras existentes no museu.
Práticas musicais e mídia – (in)visibilidades contemporâneas e distinção social no Instituto Anelo (Campinas-SP)
Authors: Cordovio Fernando
Published: September 2023

Na pesquisa “Distinção social em práticas musicais - educação, mídia e política (CORDOVIO, 2019), procurei compreender a construção dos valores expressos por jovens componentes de uma instituição dedicada ao ensino de música ligada ao gênero instrumental, principal referência para suas práticas. Foram considerados os processos de socialização nas variadas instâncias educativas produtoras de bens simbólicos ao longo de suas trajetórias de vida. O foco, ora apresentado, articula os vieses atribuídos às experiências midiáticas tecidas no percurso institucional, aos efeitos delas depreendidos. Os resultados indicam incremento de capitais diversos pelos jovens (culturais, sociais, econômicos), bem como à possibilidade de sua sujeição a violências simbólicas subjacentes àquelas vivências.
A câmera, o flâneur e a história
Authors: Santos Wanderson Barbosa dos
Published: September 2023

Este estudo aborda a relação entre fotografia e o pensamento socio-filosófico. O mote para a reflexão são os diálogos entre as produções de Walter Benjamin, Gisèle Freund e Germaine Krull. A filosofia de Benjamin, os estudos sociológicos de Gisèle Freund e as fotografias de Germaine Krull, compõem um capítulo importante para a história do desenvolvimento da fotografia, tal como, são representativos de um conjunto de leituras que emergem da intersecção do debate sobre técnica, arte e modernidade. Num contexto de ascensão dos regimes autoritários na Europa, Benjamin, Freund e Krull, encontram na situação de exílio em Paris um ponto de encontro para o desenvolvimento de seus trabalhos intelectuais. No exílio parisiense, as obras desses três pensadores da modernidade se entrelaçam num diálogo relevante sobre os desdobramentos do avanço da técnica fotográfica e seu papel na apreensão das transformações do mundo urbano.
Вічна і Світла Пам’ять Метру Поліграфії
Authors: НН ВПІ КПІ ім. Ігоря Сікорського Науково-педагогічний колектив
Published: September 2023

Некролог про життєвий і науковий шлях відомого науковця і викладача, метра видавничо-поліграфічної справи, професора, кандидата технічних наук, дійсного члена Академії інженерних наук України, багаторічного декана ВПФ, зав. кафедри ТПВ ВПФ НТУУ «КПІ», члена спеціалізованих вчених рад ВПІ НТУУ «КПІ» та УАД, редакційних колегій багатьох фахових наукових журналів та збірників, одного із засновників і заступників головного редактора збірника наукових праць «Технологія і техніка друкарства» Олега Федоровича Розума.
The effect of personal factors and situational factors on impulse buying on Tiket.com users in Indonesia
Authors: Fitri Fatharani Aghnia , Millanyani Heppy
Published: September 2023

This study aims to examines the effect of personal factors and situational factors on impulse buying in the context of impulse tourism especially on Tiket.com users in Indonesia. The survey method was used, and questionnaires were distributed to Tiket.com users. A sample of 400 respondents and the data were analyzed using multiple regression analysis with the help of SPSS 26 version software. The findings reveal that impulse buying tendency (IBT), materialism (MT), use of credit cards (CCU), personal situation (PS), motivational activities by retailers (MAR), serendipity information (SI) have a positive and significant effect on impulsive buying among Tiket.com users in Indonesia. Higher level of IBT, MT, CCU, PS, MAR, and SI variables increase the impulse buying impulse purchases for Tiket.com users in Indonesia. However, the research shows that website quality (WQ) and product attributes (PA) have a negative and significant influence on impulsive buying. The shopping enjoyment tendency (SET) and scarcity (SC) have no effect on impulsive buying (IB) for Tiket.com users in Indonesia. Based on these findings, it is suggested that further studies be conducted utilizing the same model with various objects to compare impulse purchases among Online Travel Agent (OTA) users and provide new insights into consumer behaviour, along with explore other factors that influence impulse purchases.
Endo-Periodontal Lesions ---An Ignored Oral Etiology of Odontogenic Sinusitis
Authors: Wu Jianyou , Zheng Ming , Wang Xiangdong , Wang Songlin
Published: September 2023

The aim of the study was to analyze the oral etiology of patients with odontogenic sinusitis (ODS）and to compare the differences in demographic data, clinical symptoms, extent of sinus involvement, bone penetration of the maxillary sinus floor (MSF) between different etiologies. A retrospective investigation was conducted on 103 patients with ODS recruited from Beijing Tongren Hospital. All enrolled patients underwent sinus CT, nasal endoscopy, and oral examination. A comparison of the patients' clinical symptoms, extent of involvement of the sinuses, and bone resorption of the MSF according to odontogenic etiologies was conducted. Follow-up was based on symptoms, clinical examination. The most common odontogenic etiologies were endo-periodontal lesions (EPL. 49.5%), apical periodontitis (AP, 32.0%) and periodontitis (PE, 8.7%). There were statistically significant differences in age (P=0.002), sex (P=0.036), inflammation involving the ethmoid sinus (P=0.037), and bone penetration of the MSF (P<0.001) between the AP, EPL, and PE groups. There were no significant differences in sinusitis symptoms (P>0.005) among patients with different odontogenic etiologies. In conclusion, EPL is a neglected oral etiology with a destructive effect on the bone of the MSF, and Should receive more attention in diagnosis and treatment.
In Silico Drug Re-Purposing Studies for the Discovery of Novel MbtA Inhibitors
Authors: Rakshit Gourav , Biswas Abanish , Jayaprakash Venkatesan
Published: September 2023

Tuberculosis (TB) continues to pose a global health challenge, exacerbated by the rise of drug-resistant strains. The development of new TB therapies is an arduous and time-consuming process. To expedite the discovery of effective treatments, computational structure-based drug re-purposing has emerged as a promising strategy. From this perspective, conditionally essential targets present a valuable opportunity, and the mycobactin biosynthesis pathway stands out as a prime example highlighting the intricate response of Mycobacterium tuberculosis (Mtb) to changes in iron availability. This study focuses on the re-purposing and revival of FDA-approved drugs (library) as potential inhibitors of MbtA, a crucial enzyme in mycobactin biosynthesis in Mtb conserved among all species of mycobacteria. Literature suggests this pathway to be associated with drug efflux pumps, which potentially contribute to drug resistance. This makes it a potential target for antitubercular drug discovery. Herein we utilized cheminformatics and structure-based drug repurposing approaches, viz., molecular docking, dynamics, and PCA analysis, to decode the intermolecular interactions and binding affinity of the FDA-reported molecules against MbtA. The virtual screening revealed ten molecules with significant binding affinities and interactions with MbtA. These drugs, originally designed for different therapeutic indications (4: antiviral, 3: anticancer, 1: CYP450 inhibitor, 1: ACE inhibitor, and 1: leukotriene antagonist), are repurposed as potential MbtA inhibitors. Furthermore, our study explores the binding modes and interactions between these drugs and MbtA, shedding light on the structural basis of their inhibitory potential. Principal component analysis highlighted significant motions in MbtA-bound ligands, emphasizing the stability of the top Protein-Ligand Complexes (PLCs). This computational approach provides a swift and cost-effective method for identifying new MbtA inhibitors, which can subsequently undergo validation through experimental assays. This streamlined process is facilitated by the fact that these compounds are already FDA-approved and have established safety and efficacy profiles. This study has the potential to lay the groundwork for addressing the urgent global health challenge at hand, specifically in the context of combating Antimicrobial Resistance (AMR) and Tuberculosis (TB).
Reinforcement Learning and Stochastic Optimization with Deep
Learning based Forecasting on Power Grid Scheduling
Authors: Yang Cheng , Zhang Jihai , Jiang Wei , Wang Li , Zhang Hanwei , Yi Zhongkai , Lin Fangquan
Published: September 2023

Continuous greenhouse gas emissions are causing global warming and impacting the habitats of many animals. Researchers in the field of electric power are making efforts to mitigate this situation. Operating and maintaining the power grid in an economic, low-carbon, and stable is challenging. To address the issue, we propose a grid dispatching technique that combines prediction technology, reinforcement learning, and optimization technology. Prediction technology can forecast future power demand and solar power generation, while reinforcement learning and optimization technology can make charging and discharging decisions for energy storage devices based on current and future grid conditions. In the power system, the aggregation of distributed energy resources increases uncertainty, particularly due to the fluctuating generation of renewable energy. This requires the use of advanced predictive control techniques to ensure long-term economic and decarbonization goals. In this paper, we present a real-time dispatching framework that integrates deep learning-based prediction, reinforcement learning-based decision-making, and stochastic optimization techniques. The framework can rapidly adapt to target uncertainty caused by various factors in real-time data distribution and control processes. The proposed framework achieved global Champion in the NeurIPS Challenge 2022 competition and demonstrated its effectiveness in practical scenarios of intelligent building energy management.
Study Into the Fire and Explosion Characteristics of Polymer Powders Used in Engineering Production Technologies
Authors: Kuracina Richard , Szabová Zuzana , Buranská Eva , Kosár László , Rantuch Peter , Blinová Lenka , Měřínská Dagmar , Gogola Peter , Jurina František
Published: September 2023

Polymers and their processing by engineering production technologies (injection, moulding or additive manufacturing) are being increasingly used. An explosive atmosphere can be created by the powder form of these polymer materials, and introduction of preventive safeguards to control safety is required for their use. Determination of the fire parameters of powder samples of Polyamide PA12, Polypropylene, and ultra-high molecular weight polyethylene (UHMW Polyethylene) is the subject of the current article. The results showed? that one of the samples used was not flammable and thus safe for use in terms of explosiveness. Two samples were flammable and explosive. The lower explosive limit was 30 g.m-3 (Polyamide PA12) and 60 g.m-3 (UHMW Polyethylene). The maximum explosion pressure of the samples was 6.47 (UHMW Polyethylene) and 6.76 bar (Polyamide PA 12). The explosion constant Kst of the samples was 116.6 bar.m.s-1 (Polyamide PA 12) and 97.1 bar.m.s-1 (UHMW Polyethylene). Therefore, when using polymers in production technologies, it is necessary to know their fire parameters, and to design effective explosion prevention measures for flammable and explosive polymers.
Simplified Multivariate Linear Regression based Model to Predict Asphaltene Onset Pressure under Reservoir Pressure Depletion Conditions using Data Clustering Technique
Authors: Ali Muhammad
Published: September 2023

The precipitation, flocculation, and deposition of asphaltene cause severe formation damage within a reservoir and shorten a well’s productive life. Pressure depletion is one factor that contributes to asphaltene precipitation during production; therefore, the first step in managing asphaltene is to determine the onset pressure of the precipitation. While there are numerous equation of state models that can be used to predict the onset pressure, these models are complex and heavily reliant on tuning parameters. Using multivariate linear regression, this work attempts to develop a simple and accurate thermodynamic model for predicting the upper precipitation onset pressure under pressure depletion above the bubble point pressure (Pb) at various temperatures. A total of 94 experimental data points from 37 published crude oil data sets were compiled from the literature. To develop the model, 59 experimental data points were used as training data and 35 experimental data points as testing data. According to the results of the multicollinearity test, the bubble point pressure, temperature, resins, and saturate-to-aromatic ratio were chosen as predictors. The upper onset pressure data with comparable trends were clustered, and unsupervised recognition of three distinct cluster groups was performed. For each cluster identified, a multivariate linear regression model was developed. The model was chosen based on Mallow’s coefficient of determination (Cp), adjusted R2 (statistical measure of fit), and S (standard error of the regression slope). The developed model was tested using a data set, and the results showed an adjusted R2 of 96.25%, with a mean absolute error of 4.1%. The model was randomly applied to 15 data points to compare it to perturbed-chain statistical associated fluid theory (PC SAFT) and the Peng-Robinson equation of state models and to the multivariate regression models of Fahim (2007) and Ameli et al. (2016). The results showed that the mean absolute error for predicting the asphaltene precipitation onset pressure was 2.82% using Peng-Robinson, 2.36% using the PC SAFT equation of state, 23.96% using the Fahim model, 24.80% using the model reported by Ameli et al., and 2.39% using the newly developed multivariate regression model. The developed multivariate model appears to be as accurate as the PC SAFT equation of state modeling with tuning parameters. The primary advantage of multivariate regression is that, unlike the PC SAFT equation of state model, it does not require saturates, aromatics, resins, and asphaltenes (SARA)-based characterization methodologies or rigorous parameter tuning. It is simple to use, quick, and it produces results in a short period of time.
Gut Bacterial Community Determines the Therapeutic Effect of Ginsenoside on Canine IBD by Modulating the Colonic Mucosal Barrier
Authors: Mao Aipeng , Zhao Weigang , Zhu Yuhang , Kong Fantao , Chen Danyang , Si Huazhe , Xu Chao
Published: September 2023

Inflammatory bowel disease (IBD) comprises systemic inflammatory conditions primarily affecting the gastrointestinal tract, including Crohn's disease and ulcerative colitis. This research aims to analyze the clinical symptoms and pathogenesis of Dextran sodium sulfate (DSS)-induced canine IBD model, and evaluate the restorative effect of ginsenoside from a pathogenesis perspective. We established the DSS-induced canine IBD model and studied the pathological mechanisms. Additionally, we examined the therapeutic effect of ginsenosides by assessing the Canine Inflammatory Bowel Disease Activity Index (CIBDAI), C-reactive protein (CRP) levels, colonic tissue morphology, protein expression, and mucosal bacterial community analysis. Our findings revealed a total ginsenoside content of 22.7% in the ginsenoside extract. Animal experiments demonstrated that dogs with IBD exhibited decreased mental state, significantly increased CIBDAI and CRP levels, disrupted colonic epithelial tissue structure, decreased expression of mucin, tight junctions, and adherens junctions, as well as reduced diversity of the colonic mucosal bacterial community. Furthermore, correlation analysis highlighted a total of 38 bacterial strains correlated with physiological indices. Significantly, ginsenoside treatment could improve these symptoms and reverse the relative abundance of some bacterial communities. In conclusion, Alterations in the properties of the colonic mucus layer or the reduction of MUC2, its core component, in dogs with IBD can lead to bacterial penetration of the mucus layer and subsequent contact with intestinal epithelial cells, resulting in inflammation. Remarkably, ginsenoside intervention showcased the capacity to positively influence the relative abundance of bacteria and impact the colonic mucus layer properties, thereby offering promising prospects for IBD management and recovery.
Camouflaging Endovascular Stents With an Endothelial Coat Using CD31 Domain 1 Mimetic Peptides
Authors: Sénémaud Jean , Skarbek Charles , Hernandez Belen , Song Ran , Pan Zhongcheng , Lefevre Isabelle , ฺBianchi Elisabetta , Castier Yves , Nicoletti Antonino , Bureau Christophe , Caligiuri Giuseppina
Published: September 2023

Background: Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells, platelets, and circulating leukocytes. The aim of this study was to mask endovascu-lar stents with peptides imitating CD31, to mimic the device's surface to resemble that of a healthy vascular endothelium. Methods: Peptide design relied on established trans-homophilic sequences found within domains 1 and 2 of CD31. Subsequently, synthetic peptides were immobilized onto flat CoCr and nitinol discs and their impact on the primary human arterial endothelial cell phenotype was evaluated in vitro. Following this, clinical-grade CoCr and nitinol endovascular devices were coated with one of the peptides that demonstrated the capability to induce a pro-physiologic endothelial phenotype, implanted in the arteries of rabbits, and compared to un-coated controls. Results: Membrane-distal CD31 domains 1 and 2 peptides exhibited a distinct capability to foster a healthy endothelial phenotype in vitro. By day 7 post-aortic implantation, CoCr stents were evenly covered by whole-some endothelial cells, devoid of thrombo-inflammatory signs, in contrast to both bare metal and drug-eluting stents. At day 60, nitinol-coated flow diverters demonstrated enhanced performance in comparison to the control groups for excluding experimental carotid aneurysms, facilitating the formation of a seamless "neo-arterial" wall. Conclusion: Membrane-distal CD31 biomimetic peptides effectively camouflage the device surface, prevent-ing local reactions and promoting rapid and seamless endovascular integration.
Addressing Catheter Lock Therapy: Does Heparin Reduce the Bioactivity of Dalbavancin When Together in Solution during Freezing?
Authors: Díaz-Navarro Marta , Hafian Rama , Manzano Irene , Pérez-Granda María Jesús , Cercenado Emilia , Rodríguez Carmen Guadalupe , Muñoz Patricia , Guembe María
Published: September 2023

We tested the bioactivity of a dalbavancin + heparin (DH) vs. dalbavancin (D) against biofilms of Staphylococcus aureus ATCC43300 (MRSA) and Staphylococcus epidermidis ATCC35984 (MRSE) comparing DH median value of cfu counts and metabolic activity with that obtained for D before and during storage under freezing up to 6 months. The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.
Electron Swarm Parameters of Alcohols from Electron Collision Cross–Sections
Authors: Da Silva Marcelo Gomes , Ballester Maikel Yusat
Published: September 2023

The rationalization and modeling of an electric discharge in a fluid require the knowledge of electron swarm parameters. In this work, transport coefficients of alcohols, including methanol, ethanol, propanol, and butanol are reported. The electron energy distribution function, mean energy, reduced mobility, and diffusion coefficient, are calculated using the two-term expansion of the electron Boltzmann equation in the frame of BOLSIG+ and the Monte Carlo collision code METHES. For such, experimental and theoretical values of the electron-alcohol collision cross-section, covering a range of electron impact energy from 1 eV to 1000 eV, are employed. A temperature of 300K, reduced fields E/N between $1-10^4$ Td (1Td = $10^{-21}~\rm Vm^2$), and Plasma density of $10^{19}~\rm m^{-3}$ were used in simulations. The calculated coefficients are compared with data available from previous studies.
The evaluation of main results of the RMO Key and Supplementary comparisons for electrical power and energy
Authors: Velychko Oleh , Gordiyenko Tetyana
Published: September 2023

To overcome technical barriers in trade between countries, special international agreements on mutual recognition (MRA) of measurement results play an important role. National Metrology Institutes (NMIs) and Designated Institutes (DIs) play a major role in the implementation of these agreements. NMI and DI standards periodically participate in international comparisons to establish their equivalence to other similar standards. A comparative analysis of the results of NMI/DI participants of COOMET.EM-K5 of alternating current active power and GULFMET.EM-S5 of alternating current active and reactive energy comparisons, both in terms of regional and metrological traceability for Regional Metrology Organizations, was carried out. This analysis is related to the need to minimize the cost of NMIs/DIs in order to achieve the required metrological traceability, taking into account the geographical location of the leading NMIs. For checking consistency of these comparisons data ware used En number and z scores. The results for all participants of the comparisons are satisfactory both for En number and z scores.
MobiLithics: Fingerprinting the exploitation of lithic resources during the Upper Pleistocene
Authors: Soto María , Morales Juan , Aouraghe Hassan , Sala-Ramos Robert , Chacón M. Gema
Published: September 2023

MobiLithics is a multiscalar project aimed at characterizing the lithic resources exploitation and territorial adaptive responses among the last Homo neanderthalensis and Homo sapiens to different climatic, cultural, and biological dynamics. The project focuses on the Middle-to-Later Stone Age, in North Africa, and the Middle to Upper Palaeolithic Transition in the Mediterranean basin of the Iberian Peninsula, as key scenarios for the origin and expansion of our species. Results on geospatial modelling, petrographic and geochemical analyses, and multivariate statistics and predictive models determine the variability on resource procurement and territorial structure. These will contribute to the international debate on the adaptability of our species to different palaeoenvironments, sociocultural realities, and changing climatic conditions.
On the mythic sound of vacuum tubes
Authors: Fanton Jean-Pierre
Published: September 2023

Vacuum tube audio preamplifiers have recently found renewed interest. This study recalls the main requirements that this type of equipment must meet, and analyzes an example. The experimental approach followed to measure performances is described. These performances are exposed, and the associated uncertainties are determined. The reviewed example meets the advertised specifications.
Strategic Formulations and Financial Distress: Insights from Sales Growth and Profitability Ratios
Authors: Prapanca Detak , Kumalasari Herlinda Maya
Published: September 2023

This research looks into the complex relationship between sales growth, profitability ratios, and financial difficulty in businesses. It aims to provide practical recommendations to firm management for using sales growth and profitability data to identify and avoid financial crisis. Using a quantitative method, secondary data obtained from publicly traded companies' financial statements over a specific time period forms the basis of research. Multiple linear regression models are used to examine the relationship between sales growth and profitability ratios (the independent variables) and financial distress (the dependent variable). Statistical tests, such as ANOVA and t-tests, are used to assess the model's significance and regression coefficients. The findings show a significant relationship between sales growth, profitability ratios, and financial difficulty. Higher sales growth, in particular, is associated with an increased likelihood of financial trouble, as evidenced by the positive coefficient. Similarly, an increase in profitability ratios is linked to a higher probability of financial difficulty. This emphasizes the importance of sales growth and profitability ratios as signs of financial crisis. It is recommended that firm management closely monitor these indicators and include them into the company's financial risk management strategy in order to anticipate or mitigate possible financial difficulties. This study provides diverse stakeholders with critical insights and tools for efficiently understanding, identifying, and managing financial risks.
Personal Growth Initiative across the life span. A Systematic Review Protocol of quantitative studies using the Personal Growth Initiative Scale-II
Authors: Verdoodt Katleen , Simons Marianne , de Hoog Natascha , Reijnders Jennifer , Jacobs Nele
Published: September 2023

Background: Personal Growth Initiative (PGI) a multi-dimensional construct, conceptualized as a skill set that helps individuals to intentionally grow is considered an important construct throughout the life span. Coping with the challenges, transitions, experiences and stressors of life requires an active growth orientation. In previous empirical research, the construct has been measured by either the PGIS-I or PGIS-II, of which only the latter takes account of the theoretically established multi-dimensionality of the construct. This paper describes the protocol for conducting a systematic review of published peer-reviewed empirical research articles on the multi-dimensional construct of PGI. The aim of this review is threefold: 1) to better understand the multi-dimensional construct PGI in different contexts and populations, 2) to obtain an overview of its associations with relevant psychosocial factors, 3) to improve our understanding of the reliability and validity of the PGIS-II in various research populations.
Methods: For the development of this protocol, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) reporting guidelines were used. Four databases and one registry will be searched using a predetermined search strategy for relevant studies. Studies will be screened, by two reviewers independently, against the established inclusion criteria. During the data extraction process, the quality of the included studies will be assessed using the Quality Assessment for Survey Studies in Psychology (Q-SSP). The collected data will then be analysed and reported in both narrative and tabular form according to the PRISMA 2020 statement guidelines and flow diagram.
Discussion: The findings of this study will increase our understanding of the dynamics of PGI throughout the lifespan, its associations with other psychosocial factors and the psychometric properties of the PGIS-II. It will also clarify where additional research is needed. The objectives of the proposed review can provide a basis for the development of practical applications and interventions.
Systematic review protocol registration:International Prospective Register for Systematic Reviews (PROSPERO) CRD42022377342
Promethazine for nausea and vomiting prevention after gynaecological laparoscopic surgery：a randomized controlled trial
Authors: Ruijuan Liu , Ruirui Bi , Jiqiang Zhang , Wenjun Yan , Xia Li , Yuxi Su , Yani Zhang
Published: September 2023

Background: Postoperative nausea and vomiting (PONV) are the postoperative problem that patients undergoing surgery do not want to experience. The incidence of PONV in female patients undergoing laparoscopic surgery is about 40%, and the risk of PONV is as high as 80% in those patients who have not received preventive treatment. At present still did not have the consummation effective solution.
Methods: This prospective, single-centre, two-armed, randomised, double-blind, pilot study was conducted in Gansu Provincial Hospital from June 2021 to March 2022 and included 100 subjects, aged 18–65 years, who underwent nonemergent gynaecological laparoscopic surgery. Before anaesthesia induction, 6.25-mg promethazine or 1-mL saline was intravenously administered. All subjects received postoperative patient-controlled intravenous analgesia and continuous metoclopramide infusion at 50 mg. The primary outcome was the incidence and severity of postoperative nausea and vomiting at 6 h, 24 h, 48 h, and 72 h postoperatively.
Results:The incidence and severity of nausea during the early period (the first 6 h postoperatively) was significantly different between groups (P = 0.043, P = 0.048). A statistically significant difference was found in the incidence and severity within 24 h postoperatively (P = 0.026, P = 0.003). Vomiting incidence and severity were lower than in the control group at the 6 h postoperatively but without statistical difference between the two groups (P = 0.166, P = 0.180). Vomiting incidence and severity were statistically different during the 24 h postoperatively (P = 0.011, P = 0.004). A significant statistical difference was found in the satisfaction between the two groups during the postoperative observation period (P = 0.002).
Conclusion:Preoperative prophylactic promethazine significantly reduced the incidence and severity of postoperative nausea and vomiting within 24 h postoperatively, with few adverse effects and no serious adverse reactions. And the satisfaction of patients is improved.
Clinical Trials Registration Number:（18/12/2021）ChiCTR2100054495
Improving the prediction of protein stability changes upon mutations by geometric learning and a pre-training strategy
Authors: Gong Haipeng , Xu Yunxin , Liu Di
Published: September 2023

Accurate prediction of the fitness and stability of a protein upon mutations is of high importance in protein engineering and design. Despite the rapid development of deep learning techniques and accumulation of experimental data, the multi-labeled nature of fitness data hinders the training of robust deep-learning-based models for the fitness and stability prediction tasks. Here, we propose three geometric-learning-based models, GeoFitness, GeoDDG and GeoDTm, for the prediction of the fitness score, ΔΔG and ΔTm of a protein upon mutations, respectively. In the optimization of GeoFitness, we designed a novel loss function to allow supervised training of a unified model using the large amount of multi-labeled fitness data in the deep mutational scanning (DMS) database. By this means, GeoFitness efficiently learns the general functional effects of protein mutations and achieves better performance over the other state-of-the-art methods. To further improve the downstream tasks of ΔΔG/ΔTm prediction, we re-utilized the encoder of GeoFitness as a pre-trained module in GeoDDG and GeoDTm to overcome the challenge of lack of sufficient amount of specifically labeled data. This pre-training strategy in combination with data expansion remarkably improves model performance and generalizability. When evaluated on the benchmark test sets (S669 for ΔΔG prediction and a newly collected set S571 for ΔTm prediction), GeoDDG and GeoDTm outperform the other state-of-the-art methods by at least 35% and 70%, respectively, in terms of the Spearman correlation coefficient between predicted and experimental values. An online server for the suite of these three predictors, GeoStab-suite, is available at http://structpred.life.tsinghua.edu.cn/server_geostab.html.
Preoperative eGFR can predict short-term death and hospital stay in patients with acute aortic dissection
Authors: Kong biao , zhao long , zhu qianqian , shen dongli
Published: September 2023

Background
Acute aortic dissection (AAD) is a life-threatening disease and requires urgent treatment. We assessed the relationship between preoperative eGFR in patients with acute aortic dissection and short-term death and hospital stay.
Methods
Patients were categorized based on the eGFR. Logistic regression analysis was performed to assess whether the eGFR was a risk factor for 7-day,28-day, and 60-day mortality. The Kaplan-Meier survival curve was used to analyze the relationship between the eGFR and the 7-day, 28-day, and 60-day survival rates in AAD.
Results
A total of 122 patients with AAD were enrolled. There were 94 males (77%), with a mean age of 57.75 ± 13.52 years. The total mortality amounted to 23/122 patients (18.9%): 18 (14.8%) patients died within 7 days and 23 patients died within 60 days. The multiple logistic regression analysis showed eGFR [HR = 0.284, 95% CI (0.103-0781), P = 0.015] and MBP [HR = 0.165, 95% CI (0.051-0533), P = 0.003] were independent risk factors for 60-day mortality. The correlation analysis showed that the levels of eGFR are inversely proportional to the length of hospital stay (R2 = 0.209, P = 0.039). The Cox regression analysis showed that eGFR [HR = 0.264, 95% CI (0.086–0.809), P = 0.020], BMI [HR = 3.178, 95% CI (1.095–9.225), P = 0.033], treatment methods [HR = 49.776, 95% CI (5.915–418.880), P < 0.001] are associated with the length of hospital stay.
Conclusions
Lower preoperative eGFR is associated with higher 7-days,28-days, and 60-day death and the length of hospital stay in AAD patients. By improving renal perfusion and maintaining the stability of eGFR, the prognosis of these patients may be enhanced.
Study on the lignin-derived sp2 -sp3 hybrid hard carbon materials and the feasibility for industrial production
Authors: Long Si-Yu , Liu Jin-Lei , Xian Xue-Quan , Zhou Ling-Qiang , Lv Wen-Da , Tang Pei-Duo , Du Qi-Shi
Published: September 2023

Hard carbon has been widly used in anode of lithium/sodium ion battery, electrode of supercapacitor, and carbon molecular sieve for CO2 capture. In this study the lignin derived hard carbon products are investigated, and the conclusions are abstracted as follows. (1) The lignin derived hard carbon products consist of microcrystal units of sp2 graphene fragments, jointed by sp3 carbon atoms and forming sp2-sp3 hybrid hard carbon family. (2) From the lignin precursor to the sp2-sp3 hybrid hard carbon products, most carbon atoms retain their original electron configurations (sp2 or sp3) and keep their composition in lignin. (3) The architectures of lignin-derived hard carbon materials are closely dependent on the forms of their lignin precursors, and could be preformed by different pretreatment techniques. (4) The carbonization of lignin precursors follows the mechanism “carbonization in situ and recombination nearby”. (5) Due to the high carbon ratio and abundant active functional groups in lignin, new activation techniques could be developed for control of pore size and pore volume. In general lignin is an excellent raw material for sp2-sp3 hybrid hard carbon products, a green and sustainable alternative resource for phenolic resin, and industrial production for lignin derived hard carbon products would be feasible.