bluuebunny/crossref_metadata_2025 huggingface dataset:
Corticosteroid Prescribing Patterns in the Emergency Department for Acute Chronic Obstructive Pulmonary Disease Exacerbations: A Retrospective Analysis Following an Educational Intervention
Authors: Nedzlek Christopher , Blanchett Jacob , Illg Zachary , DiGiacinto Geoffrey , Cunningham Kathryn , Wisniewski Samuel J. , Tuttle Jacob
Published: October 2024

INTRODUCTION

COPD is a progressive lung disease with marked airflow limitation. It has a large global prevalence and is managed with antibiotics, bronchodilators, and corticosteroids. Despite the prevalence, corticosteroid prescribing regimens differ widely amongst providers. This study aims to evaluate baseline corticosteroid prescribing patterns, the ability to change corticosteroid prescribing patterns with the utilization of an educational initiative, and to evaluate the effect of corticosteroid dose on length of stay, 30-day hospital readmission, mortality, and total hospital insulin dosing.

METHODS

This study was conducted via a retrospective observational study. Providers at a single institution answered a baseline questionnaire on COPD corticosteroid prescribing patterns and subsequently received an educational presentation regarding evidence-based corticosteroid recommendations. Data were then retrospectively obtained and analyzed evaluating corticosteroid prescribing patterns both pre- and post-educational intervention. Data were analyzed using IBM SPSS Version 25.

RESULTS

The provider survey revealed that most (95.3%) administered 125 mg of methylprednisolone to patients treated for AECOPD. The most common reason a particular dose of corticosteroid was administered was due to previous teaching or practice patterns. The mean initial steroid dose of methylprednisolone decreased following the educational initiative from 114.24 mg to 72.8 mg (p < 0.01). This corresponded to a 69% (n=41) decrease of providers using 125 mg methylprednisolone (p < 0.01), and increased prescribing of 62.5 mg methylprednisolone by 42.6% (n=66). The mean LOS following hospital admission for AECOPD in the pre-intervention group was 5.80 days, while the mean LOS following the targeted educational intervention decreased to 4.82 days (p = 0.01).

CONCLUSIONS

The implementation of an educational intervention may change provider corticosteroid prescribing patterns. Additionally, lower corticosteroid dose in the Emergency Department may decrease patient length of stay. Keywords: Corticosteroid, COPD, LOS, recommendations, steroid
PARADIGMA PENGADILAN ANAK (Analisis Atas UU No. 3 Tahun 1997 tentang Pengadilan Anak)
Authors: Aniek Periani
Published: October 2024

Kasus-kasus kejahatan yang melibatkananak sebagai pelaku tindak kejahatanmembawa fenomena tersendiri. Mengingatanak adalah individu yang masih labilemosinya, maka penanganan kasus kejahatan/kenakalan anak perlu mendapat perhatiankhusus. Kenakalan anak dalam masyarakatdisebabkan adanya perilaku anak yangbertentangan dengan norma yang ada dalammasyarakat, yang salah satunya adalah normahukum. Fenomena perilaku anak yangbertentangan dengan norma-norma yang adadalam masyarakat perlu dipahami, dalamrangka untuk penanggulangannya.Upaya penanggulangan kenakalan anakmelalui jalur penal lebih bersifat represif,berbeda dengan upaya jalur non penal yangbersifat preventif. Namun menurut BardaNawawi Arief, pada hakikatnya tindakanrepresif juga dapat dilihat sebagai tindakanpreventif dalam arti luas. Pengkajian terhadapkenakalan anak yang menyangkut tentang anaknakal dalam kebijakan penal lebihmemfokuskan kepada sarana penal yaitu iusconstitutum dan ius operatum belaka danmengabaikan kebijakan non penal.Sehubungan dengan kebijakan penal untukpenanggulangan anak nakal di Indonesia,ternyata masih menimbulkan permasalahandalam perlindungan terhadap anak.Perlindungan terhadap anak telahmenjadi kesepakatan internasionalsebagaimana diamanatkan dalam DeklarasiJenewa tentang Hak Anak-anak tahun 1924,yang selanjutnya telah mendapat pengakuandalam Deklarasi Sedunia tentang Hak AsasiManusia serta ketentuan hukum yang dibuatoleh badan khusus dan organisasi internasionalyang memberi perhatian bagi kesejahteraananak-anak. Jauh hari Majelis Umum PBBmemaklumkan Deklarasi Hak Anak denganmaksud agar anak-anak dapat menjalani masakecil yang membahagiakan, berhak menikmatihak-hak dan kebebasan baik untuk kepentinganmereka sendiri maupun untuk kepentinganmasyarakat.
The DisputeResolutionof Oil Pollutionby Tan/fer Ship In IndonesianLegal System
Authors: Elly Kristiani Purwendah  , Marsudi Triatmodjo
Published: October 2024

The choice of oil pollution dispute resolution by Tanker Ship in national marine law system is highly important to be analyzed in-depth concerning the choice of oil pollution dispute resolution by Tanker Ship in Indonesia is resolved in peaceful manner based on the principle of polluter pays principle. The dispute resolution choice in peace is amended by the internationalinstrument ofUNCLOS in article 279 which is, in Indonesianpositive law system, generated through several national legal  instruments. Furthermore, the  dispute resolution choice is such an important thing considering   the purposes of marine environment protection by the coastal states through the law enforcement of sovereign coastal  states.  The  consequence of  dispute resolutionchoice with the concept of ecocracy and sustainable environmental development, in  line with  the  reconstructive  purpose  of philosophical approach of environmental problem  settlement  through the concept  of ecocracy and the paradigm of deep ecology and green constitution, itis expected to be able to be included in national legal system withe law  enforcers  who  understand  ecoliteracy
Long-term (2010–2021) lidar observations of stratospheric aerosols in Wuhan, China
Authors: He Yun , Jing Dongzhe , Yin Zhenping , Ohneiser Kevin , Yi Fan
Published: October 2024

Abstract. This study analyzes the vertical distribution, optical properties, radiative forcing, and several perturbation events of stratospheric aerosols using observations from a ground-based polarization lidar in Wuhan (30.5° N, 114.4° E) from 2010 to 2021. The background stratospheric aerosol optical depth (sAOD) was 0.0044 ± 0.0019 at 532 nm, as calculated during a stratosphere-quiescent period from January 2013 to August 2017. In addition, several cases of volcanic aerosol and wildfire-induced smoke were observed. Volcanic aerosols from the Nabro (2011) and Raikoke (2019) eruptions (both in boreal summer) increased the sAOD to 2.9 times the background level. Tracers of smoke from the Canadian wildfire in the summer of 2017 were observed twice, at 19–21 km on 14–17 September and at 20–23 km on 28–31 October, with a plume-isolated aerosol optical depth (AOD) of 0.002–0.010 and a particle linear depolarization ratio δp of 0.14–0.18, indicating the dominance of non-aged smoke particles. During these summertime events, the injected stratospheric aerosols were captured by the large-scale Asian monsoon anticyclone (AMA), confining the transport pathway to mid-latitude Asia. On 8–9 November 2020, smoke plumes originating from the California wildfire in October 2020 appeared at 16–17 km, with a mean δp of 0.13. Regarding seasonal variation, the sAOD in the cold half-year (0.0054) is 69 % larger than in the warm half-year (0.0032) due to stronger meridional transport of stratospheric aerosols from the tropics to middle latitudes. The stratospheric radiative forcing was −0.11 W m−2 during the stratosphere-quiescent period and increased to −0.31 W m−2 when volcanic aerosols were largely injected. These findings contribute to our understanding of the sources and transport patterns of stratospheric aerosols over mid-latitude Asia and serve as an important database for the validation of model outputs.
Updates to the Met Office’s global ocean-sea ice forecasting system including model and data assimilation changes
Authors: Mignac Davi , Waters Jennifer , Lea Daniel J. , Martin Matthew J. , While James , Weaver Anthony T. , Vidard Arthur , Guiavarc’h Catherine , Storkey Dave , Ford David , Blockley Edward W. , Baker Jonathan , Haines Keith , Price Martin R. , Bell Michael J. , Renshaw Richard
Published: October 2024

Abstract. The Forecast Ocean Assimilation Model (FOAM) is the Met Office’s operational, coupled ocean-sea ice system, which produces analyses and short-range forecasts at global and regional scales each day for various stakeholders, including defence, marine navigation and science users. This paper describes and evaluates the impacts of recent model and data assimilation (DA) updates on global FOAM when compared to its current operational version. The model updates include the use of the TEOS10 formulation for the seawater equation of state, with improved ocean model settings in the Southern Ocean and the implementation of a new sea ice model. Updates to the DA include an increase in the number of DA minimisation iterations, an improved specification of observation errors for sea surface temperature and sea level anomaly (SLA), and optimisations of the DA computational efficiency. Large-scale DA corrections for temperature have also been removed to prevent an inconsistent projection of the SLA DA signal onto large-scale temperature at depth. For one-year runs at 1/12° resolution, the new FOAM system shows a 40 % improvement in observation-minus-background (OmB) statistics for SLA and sub-surface temperatures relative to the current system in eddy-rich regions, which result in a similar level of improvement for ocean currents. To evaluate potential impacts on the pre-Argo period, one-year experiments at 1/4° resolution are run withholding profiles of temperature and salinity observations in both new and current FOAM systems. In the absence of profile DA, OmB statistics for SLA, temperature and salinity in the new FOAM system can reach improvements up to 90 % in the Southern Hemisphere relative to the current system, resulting in more temporally consistent ocean transport and heat content results. Therefore, it is expected that the model and DA updates will lead to more potential for use of FOAM reanalyses in climate studies, particularly in the pre-Argo period, and will provide improved ocean/sea-ice initial conditions to FOAM as well as to the Met Office short-range and seasonal coupled ocean/atmosphere/land/sea ice forecasting systems.
A causality-based method for multi-model comparison: Application to relationships between atmospheric and marine biogeochemical variables
Authors: Bénard Germain , Gehlen Marion , Vrac Mathieu
Published: October 2024

Abstract. We introduce an novel approach to compare Earth System Model output using a causality-based approach. The method is based on the PCMCI+ algorithm, which identifies causal relationships between multiple variables. We aim to investigate the causal relationships between atmospheric (North Atlantic Oscillation – NAO), oceanic (gyre strength, stratification, circulation), and biogeochemical variables (nitrate, iron, silicate, net primary production) in the North Atlantic subpolar gyre, a critical region for the global climate system with a well characterised multi-year variability in physical and biogeochemical properties in response to the North Atlantic Oscillation. We test a specific multivariate conceptual scheme, involving causal links between these variables. Applying the PCMCI+ method allows us to differentiate between the influence of vertical mixing and horizontal advection on nutrient concentrations, spring bloom intensity, as well as to highlight model-specific dynamics. The analysis of the causal links suggests a dominant contribution of vertical mixing to peak spring bloom intensity compared to transport. The strength of the links is variable among models. Stratification is identified as an important factor controlling spring bloom NPP in some, but not all, models. Horizontal transport also significantly influences biogeochemistry. However, horizontal transport generally exhibits lower contributions than vertical mixing. Most of the links found are model-specific, hence likely contributing to inter-model spread. The limitations of the method are discussed and directions for future research are suggested.
Technical note: Finite element formulations to map discrete fracture elements in three-dimensional groundwater models
Authors: de Rooij Rob
Published: October 2024

Abstract. Typically, in finite element groundwater models, fractures are represented by two-dimensional triangular or quadrilateral elements. When embedded in a three-dimensional space, the Jacobian matrix governing the transformation from the global three-dimensional space to the local two-dimensional space is rectangular and thus not invertible. There exist different approaches to obtain a unique mapping from local to global space even though the Jacobian matrix is not invertible. These approaches are discussed in this study. It is illustrated that all approaches yield the same result and may be applied to curved elements. The mapping of anisotropic hydraulic conductivity tensors for possibly curved fracture elements is also discussed.
Immunohistochemical Expression of ROS1 in invasive ductal carcinoma of breast in association with hormonal receptor status and Her2Neu expression
Authors: Umair Muhammad , Khan Ahmed Ahson , Jamal Nighat , Bajwa Akhter Ali , Hassan Tabish , Khan Muhammad Umair
Published: October 2024

Objective: To determine the frequency of immunohistochemical expression of ROS1 in invasive ductal carcinoma of the breast in relation to hormonal receptor status and HER2 expression.
 
Study Design and Setting: Descriptive cross-sectional study. Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi from May 2022 to Dec 2022.
 
Methodology: This study was conducted on a sample size comprising 137 patients diagnosed with invasive breast carcinoma (ductal carcinoma) on histopathological biopsy specimen. Immunohistochemistry was performed using ROS1, estrogen receptor, progesterone receptor and HER2 antibodies on patients’ tissue samples. Results were interpreted by two independent histopathologists. Finally data was analyzed using SPSS version 25.
 
Results: The mean age of sample population was 50.85 ± 12.17 years. 131 patients were women and 6 were men. ROS1 was positive in 54 cases. ROS1 shows weak staining in 41 cases and moderate to strong staining in 13 cases. ER and PR showed no significant statistical correlation with ROS1 expression. HER2 was positive in 37 cases, equivocal in 11 cases and negative in 89 cases. A significant statistical correlation was seen between ROS1 and HER2 as 23 of HER2 positive cases showed ROS1 expression (p=<0.001).
 
Conclusion: Significant number of ROS1 expressing cases in invasive breast carcinoma can be more revealing in the understanding of pathogenesis of breast carcinoma. In addition, it can also lead to use of certain recent tyrosine kinase inhibitors for treatment of this most common carcinoma in females.
Association of pre-op TSH levels with Thyroid Carcinoma in a Tertiary Care Setup in Karachi, Pakistan
Authors: Junaid Tehmina , Siddiqui Areej Fatimah Iqrar , Khan Tariq Zahid , Ahmed Zeba , Arif Basit , Kazmi Sana , Tahseen Muhammad Umair
Published: October 2024

Objectives: This study aimed to explore the relationship between pre-operative TSH levels and the presence of thyroid cancer in patients with nodular thyroid disease in the Pakistani population, using data gathered from patients treated at Dr. Ruth K. M. Pfau Civil Hospital Karachi.
 
Study Design & Setting: A cross-sectional study was conducted at the Dow University of Health Sciences and Dr. Ruth K. M. Pfau Civil Hospital Karachi from January 2022 to December 2022.
 
Methodology: Patients with thyroid swellings (presenting with either solitary nodules or with multinodular goiter), both benign as well as suspected/confirmed malignancy based on FNAC results were recruited in the study. Preoperative TSH levels, along with other clinical data, were collected. Thyroidectomy was carried out in patients fulfilling the criteria for surgery, with specimens sent for histopathology. An independent t-test was used to compare TSH levels between malignant and benign nodules.
 
Results: A total of 82 patients were enrolled. Malignancy was confirmed in 41.5% (25 papillary carcinoma, 9 follicular carcinoma). Significantly higher mean TSH levels were observed in patients with malignant nodules (4.76 IU/mL) compared to those with benign nodules (2.48 IU/mL) (p < 0.001).
 
Conclusion: This study suggests a potential association between elevated pre-operative TSH levels and thyroid cancer in the Pakistani population. These findings warrant further investigation to explore causality and potential underlying mechanisms. The study highlights the value of TSH monitoring, particularly in resource-constrained settings.
Prevalence of Dentine Hypersensitivity in Vital Abutment Teeth being prepared for Fixed Partial Dentures or Crowns
Authors: Ghuuman Maria Komil , Shad Miral , Sharafat Ammara , Afzal Maira , Anjum Rida , Ibrahim Saira
Published: October 2024

Objective: To determine the prevalence of dentine hypersensitivity during the preparation of vital abutment teeth for Fixed Partial Dentures or Crowns and its association with patient’s gender, age, and location of tooth.
 
Study Design & Setting: This is a descriptive cross-sectional study of patients with 150 abutments of either crown or fixed partial dentures, carried out in the department of Prosthodontics at Armed Forces Institute of Dentistry (AFID) Rawalpindi from June to December 2021.
 
Methodology: The Dentine Hypersensitivity was recorded on a VAS (Visual Analogue Scale) of 0-10 after the patient reported pain during exposure to thermal stimulus i.e. cold water from a 5cc syringe at 1cm distance during or just after the tooth preparation.
 
Results: In this study, the prevalence of Dentine Hypersensitivity was 13.3% with a mean dentine hypersensitivity score (VAS) for cold water test (Mean ± SD) of 0.61±1.756. Independent samples t-tests were used to determine the difference in hypersensitivity between genders, two age groups, and type of tooth (anterior/ posterior). It showed significant results with p-values of 0.002, 0.002, and 0.003 respectively.
 
Conclusion: Within the limitations of this study, it was highlighted that the preparation of vital teeth for conventional porcelain fused to metal (PFM) crown or fixed dental prosthesis results in dentine hypersensitivity in a considerable number of cases, with a higher incidence in women, younger patients, and vital anterior abutments.
Next-Gen Rehab: VR & AI Revolutionize Physiotherapy
Authors: Eman Alishba , Mehmood Kanza , Ali Hassan
Published: October 2024

The integration of Virtual Reality (VR) and Artificial Intelligence (AI) in healthcare can significantly improve patient outcomes, particularly in physiotherapy. Combining VR and AI enhances accuracy and personalization in physiotherapy, ushering in a new era of patient centered rehabilitation. VR and AR use input devices to gather data on body position, movement, and the environment, and output devices to deliver sensory feedback, including visuals, vibrations, and sounds.1
Estratégias para a promoção da cultura de segurança do paciente no centro cirúrgico: revisão sistemática
Authors: Aquino Luisa Alves Pereira de , Araújo Dayara Ainne de Sousa , Cunha Yúri de Araújo , Santos Viviane Euzébia Pereira , Saraiva Cecília Olívia Paraguai de Oliveira , Martins Quênia Camille Soares
Published: October 2024

Objetivo: Identificar estratégias efetivas para a promoção da cultura de segurança do paciente no centro cirúrgico. Método: Foi realizada uma revisão sistemática entre os meses de julho e setembro de 2022, utilizando as bases de dados LILACS, MEDLINE, CINAHL, Scopus, Web of Science, Embase e Cochrane Library. Os descritores utilizados foram: “Safety Culture”, “Patient Safety”, “Surgery” e “Surgicenters”. A avaliação da qualidade metodológica seguiu o protocolo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), utilizando o instrumento do Instituto Joanna Briggs, a escala de Jadad e os critérios descritos no Critical Appraisal Skills Programme. Após a aplicação dos critérios de elegibilidade, a amostra final consistiu em doze artigos. Resultados: As estratégias identificadas foram intervenções com o checklist de cirurgia segura, de educação permanente, handover, vídeos educativos, identificação de riscos latentes e tradução do conhecimento. Quanto ao risco de viés, metade dos estudos demonstraram confiabilidade e validade externa. Conclusão: Com base nos resultados obtidos, as estratégias mais eficazes para promover uma melhoria na cultura de segurança do paciente foram a educação permanente e o uso do Checklist de Verificação de Cirurgia Segura. Este estudo fornece subsídios para um cuidado sistematizado e qualificado.
Perfil clínico e sociodemográfico da hanseníase em menores de 15 anos com grau ll de incapacidade física
Authors: Oliveira Josuel Carlos , Rodrigues Lurdilene Ribeiro , Leite Alanna Mylla Costa , Pinheiro Eusilene Estrela , Soares Thaís Michele Lopes , Rodrigues Deyllen Junno Pereira , Soares Daniel Lemos , Ferreira Thais Furtado
Published: October 2024

Objetivo: Descrever o perfil clínico e sociodemográfico da hanseníase em menores de 15 anos com grau II de incapacidade física. Metodologia: Trata-se de um estudo descritivo com abordagem quantitativa, analisando dados de pessoas afetadas pela hanseníase com grau II de incapacidade física no período de 2018 a 2021 no estado do Maranhão. Resultados: Foram analisados 33 casos de hanseníase em menores de 15 anos já classificados com grau II de incapacidade física. O ano com maior frequência de casos foi 2018, correspondendo a 36,37% dos casos, enquanto 2020 foi o ano com menos casos registrados. Os casos eram predominantemente do sexo masculino, correspondendo a 72,73%, com idade entre 13 e 15 anos (45,46%). A cor parda foi a mais referida, sendo 54,55% dos casos, e 87,88% possuíam ensino fundamental incompleto. A forma clínica com maior número de casos de grau II de incapacidade foi a dimorfa (60,61%), seguida pela virchowiana (24,24%). A classificação operacional dos casos mostrou que 51,52% apresentavam até cinco lesões de pele e 36,36% apresentavam um nervo acometido, enquanto 63,64% tinham mais de um nervo afetado. Baciloscopia positiva foi encontrada em 24,24% dos casos. Conclusão: O grau II de incapacidade na hanseníase em menores de 15 anos representa um grande problema de saúde pública, sugerindo um diagnóstico tardio e colocando essa população em risco de incapacidades físicas permanentes, caso os casos não recebam acompanhamento adequado.
Vulnerabilidades e riscos: vivências dos adolescentes em situação de rua
Authors: Sánchez Edna Johana Mondragón , Fonsêca Karine Kimberlly Rocha da , Alves Thássila Lisley Moura , Pinheiro Patrícia Neyva da Costa , Ferreira Adriana Gomes Nogueira
Published: October 2024

Objetivo: Investigar as situações de vulnerabilidades e riscos no contexto de adolescentes em situação de rua. Método: Este é um estudo exploratório-descritivo qualitativo que incluiu 19 adolescentes em situação de rua entre agosto de 2020 e janeiro de 2021. Os dados obtidos foram submetidos à análise temática do conteúdo. Resultados: As seguintes categorias se destacaram: relacionamento conturbado e discriminação sexual por familiares; julgamento e preconceito social; abandono escolar por falta de estrutura econômica e familiar; problemas de saúde adquiridos na rua. Conclusão:  Os adolescentes em situação de rua estão expostos a diversas vulnerabilidades (p.ex., individuais, sociais e programáticas) e riscos relacionados à renda, baixa escolaridade, falta de apoio por políticas públicas, conflitos familiares e aparecimento ou agravamento de problemas de saúde. Os cenários de vida em situação de rua maximizam tais vulnerabilidades, o que reduz a qualidade e perspectiva deste grupo e favorece o uso de drogas e a ocorrência de infecções sexualmente transmissíveis e gravidez.
Las voces del nihilismo. La era de las patologías de civilización y la subjetividad agenésica
Authors: Romero Martín Francisco
Published: October 2024

En este trabajo intentaremos presentar al nihilismo como un acontecimiento ontológico cuyomodo de ser coincidiría con el de un agente patógeno. De este modo, y en tanto patógeno, esta crisis ontológicasería la causante del malestar global que desuela a Occidente. Por ello, nos centraremos en lograr desplegarqué efectos sintomatológicos devienen de su acción, así como si nos cupiera esperar algún remediocon el que combatirlo. Todo ello lo abordaremos desde las tesis principales del filósofo Luis Sáez Rueda.
La relación entre theoria y praxis en la filosofía antigua: del socratismo al théos aristotélico
Authors: Ruiz Moscardó Francisco Javier
Published: October 2024

Este trabajo pretende detallar la concepción metafilosófica del socratismo y del aristotelismo precisando la interrelación entre teoría y praxis que ambos proyectos desarrollan. A partir de un diagnóstico común a Michel Foucault y Pierre Hadot, según el cual el saber filosófico era inseparable en la antigüedad de una “existencia filosófica”, se expone cómo concibieron tanto Sócrates como Aristóteles este peculiar “modo de vida”, concluyéndose que las raíces del “biós theoretikós” aristotélico se encuentran en la “vida examinada” defendida por el maestro de Platón. En el transcurso de esta investigación, además, se pone de manifiesto que la dimensión teórica de la filosofía resulta prioritaria en ambos pensadores, si bien el descubrimiento de la verdad, propósito último de la teoría, acarrea consecuencias prácticas imposibles de alcanzar por una vía distinta de la contemplación filosófica. Se resuelve, por tanto, que la tensión entre la filosofía como “ciencia de la verdad” y como “ejercicio de vida” es un rasgo esencial del quehacer filosófico tal y como fue tematizado por estos dos grandes pensadores
Desigualdades vinculadas a las Tecnologías de la Información y la Comunicación (TIC): Diferencias entre escuelas públicas y privadas en Bahía Blanca, Argentina
Authors: Anderete Schwal Mariano , Marta Formichella María
Published: October 2024

El estudio aborda las desigualdades en el acceso y uso de las Tecnologías de la Información y la Comunicación (TIC) entre escuelas públicas y privadas en la ciudad de Bahía Blanca, Argentina, afectadas por la segregación socioeconómica vigente. Durante la educación remota por la pandemia de Covid-19, estas disparidades se acentuaron y evidenciaron una brecha digital entre los sectores educativos. Para llevar a cabo el análisis, se empleó un enfoque descriptivo y cualitativo, realizando entrevistas al personal directivo y docente de diversas escuelas primarias de la región. Los resultados destacan una desigualdad educativa intersectorial, evidenciando prácticas docentes y organizativas que varían según las tecnologías disponibles. Esta disparidad profundiza las diferencias en estrategias de enseñanza y experiencias educativas entre estudiantes de escuelas públicas y privadas, ampliando así la brecha educativa. Este estudio revela la influencia significativa de la brecha digital en la calidad de la enseñanza y el aprendizaje en un contexto de segregación escolar en Argentina.
Saúde ocupacional de docentes que atuam na Educação Básica: uma questão para as políticas educacionais brasileiras
Authors: da Silva Freitas Vinicius , Fernando Hansel Tiago , Roberto Gonçalves de Abreu José , Aire Vieira Maurício , Machado dos Santos Adelcio
Published: October 2024

Neste artigo, discute-se a falta de políticas educacionais que pensem na saúde ocupacional e qualidade de vida dos docentes dentro do seu ambiente de trabalho. A relevância da abordagem dá-se por esse aspecto também determinar a qualidade de ensino que será oferecido na Educação Básica. Para isso, foi realizada uma revisão de literatura com abordagem qualitativa para mostrar como as reformas educacionais com viés neoliberal contribuíram para precarização do trabalho docente e como as péssimas condições do trabalho influenciam a saúde física e emocional desses trabalhadores. Concluiu-se que muitos desistem da profissão porque não aguentam a sobrecarga e a pressão por resultados. É preciso que sejam elaboradas políticas públicas que visem a garantia de um ambiente digno, melhores condições de trabalho para evitar que a rotina escolar resulte em adoecimento e mal-estar docente.
Terra indígena Malacacheta: ocupação do espaço e uso dos recursos hídricos1
Authors: Cadete Erison da Silva , Bethonico Maria Bárbara Magalhães
Published: October 2024

O crescimento populacional verificado em terras indígenas acarreta uma reorganização do espaço. No caso da Terra Indígena Malacacheta, localizada na etnorregião Serra da Lua, no município do Cantá, Roraima, o crescimento populacional das comunidades Malacacheta e Jacaminzinho gerou a criação de novos bairros, com ocupação de espaços alternativos. Uma das consequências é o aumento do uso da água com reflexos negativos, tanto na quantidade quanto na qualidade. Diante desta realidade, o estudo buscou compreender como se deu a ampliação do espaço ocupado pelos moradores e sua relação com a bacia hidrográfica do igarapé do Cavalo, afluente do rio Quitauaú. Com o uso de dados secundários, observação e entrevistas, foi possível perceber que, com o surgimento desses novos bairros, a tendência é a ocupação do espaço no entorno dos mananciais, o que afeta os recursos hídricos com lixo e queimadas, com consequências para próximas gerações. Por não haver a sensibilização dos moradores para com recursos hídricos e sua importância, tanto na quantidade quanto na qualidade, a situação de degradação permanece e tende a aumentar.
Analisis Pengukuran Antropometri Dan Tingkat Kesegaran Jasmani: Studi Survei Pada Tim Bola Voli Putra
Authors: Rosalina Rosi , Janah Roudhotul , Hartanto Hartanto
Published: October 2024

Tujuan penelitian. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kebugaran jasmani dan kondisi antropometri atlet putra cabang olahraga Bola Voli.
Bahan dan metode. Penelitian ini menggunakan bentuk survei deskriptif dengan metode pendekatan observasional dan dianalisis menggunakan statistik deskriptif kuantitatif. Populasi dalam penelitian ini berjumlah 12 orang atlet putra cabang olahraga Bola Voli, variabel yang diteliti adalah pengukuran antropometri dan tingkat kebugaran jasmani.
Hasil. Hasil penelitian dengan jumlah sampel sebanyak 12 orang atlet Bola Voli putra menunjukkan hasil pengukuran antropometri dominan pada kategori sedang yaitu sebesar 52%. Pada tes tingkat kebugaran jasmani dominan pada kategori baik yaitu 50%. Pada tes antropometri atlet piala walikota cup 1 kota probolinggo rata-rata berada pada kategori sedang sedangkan pada tes tingkat kesegaran jasmani atlet piala walikota cup 1 kota probolinggo rata-rata berada pada kategori baik. Data yang dikumpulkan merupakan data primer melalui pengukuran Tes Kesegaran Jasmani Indonesia (TKJI) dan antropometri. Karakteristik antropometri responden berupa Berat Badan (BB), Tinggi Badan (TB) dan juga usia responden.
Cunclotion. Pelaksanaan analisis antropometri dan tes kebugaran jasmani dapat membantu atau berperan penting dalam mengevaluasi kondisi atlet untuk berprestasi ke tingkat yang lebih tinggi. Dengan adanya analisis pengukuran antropometri dan tingkat kebugaran jasmani diharapkan dapat dijadikan acuan bagi para pembina atau pelatih dalam mengetahui atlet mana saja yang memiliki kualitas yang lebih unggul sehingga dapat memberikan pembinaan yang maksimal dan atlet dapat menyumbangkan prestasi yang lebih baik lagi di kancah nasional maupun internasional.
Motivation of Running Community Members in Semarang City in Running Sport
Authors: Adi Wahyu Fitri , Candra Adiska Rani Ditya
Published: October 2024

Studi purpose. This study aims to determine the level of motivation among running community members in Semarang City regarding the sport of running.
Materials and methods. This study uses a research method employing a survey approach. The subjects in the study are members of a running community in Semarang City, totaling 50 people. Consisting of 40 men and 10 women. The research instrument uses a motivation questionnaire that has been tested for validity with a value of 0.36 - 0.75 and a reliability value of 0.946. The data analysis technique uses quantitative descriptive analysis by finding the mean, standard of deviation, minimum and maximum value, data analysis using Microsoft Excel and SPSS 25 version.
Results. Based on the results of the research on the motivation of running community members in Semarang show that their motivation level reaches 60%, which falls into the very high motivation category. In terms of intrinsic motivation, 50% of the running community members in Semarang are influenced by enjoyment aspect, with a percentage value of 35% and the fitness aspect 35%, both categorized as very high. Meanwhile, extrinsic motivation has a percentage value of 45%, driven by social interaction with 53% of the running community members in Semarang falling into the very high motivation category.
Conclusions. Based on the research findings, the motivation level of running community members in Semarang City to engage in running is classified as very high, influenced by intrinsic motivations such as enjoyment and fitness, as well as extrinsic motivations like social interaction.
A COMPARATIVE ANALYSIS OF LEGAL FRAMEWORK FOR DATA PROTECTION IN GLOBAL JURISDICTIONS
Authors: Muhammad Zain Alam  , Ghaneem Irfan Warraich
Published: October 2024

Along with the advancement in modern technology, the dependency of people on technology increased. Along with the passage of time, technology became so advanced that crimes entered the realm of cybercrimes. The article highlights the different types of data along with the basic criterion of data protection. This article refers to the critical analysis of global legislations of different states on data protection, how they intend to protect data, how they deal with the crimes such as theft, breach and misuse, and the loopholes in the legislation. All legislations related to data and their methods to tackle the data breach are endorsed, and their loopholes have been highlighted. Though every state has enacted legislation to protect data at its best, a global law is needed to protect data at the macro level. These crimes affect the individuals in the territory of a state but also make the international community vulnerable. There is a need to be proper provisions and clearly stating the jurisdiction and scope of these legislations. The blockchain system is an emerging technology system and can be used effectively to achieve the goal. Data protection is the right of every individual, and it should be preserved.
The Viability of Osteoblasts against SHED Metabolites and EGCG for Biomaterial Osteogenesis
Authors: Yuliati Yuliati , Yasmin Mahdani Fatma , Putri Khansa Shafa , Pongsumae Dealtrini , Putri Yastuti Wahidah Tsamara , Afif Wardana Muhammad , Condro Surboyo Meircurius Dwi , Aljunaid Mohammed , Rashad Qaid Huda , Sjuhada Oki Aqsa , Abbas Thalib Fitria , Devijanti Ridwan Rini , Diyatri Indeswati
Published: October 2024

Background: EGCG, the principal flavonoid found in green tea, exhibits numerous advantageous properties, notably promoting bone regeneration by enhancing the activity of osteoblasts and osteogenic differentiation. Cell-free therapy is an alternative to avoiding the side effects of cell-based therapy. By harnessing the potential of metabolites, SHED combined with EGCG can be a biomaterial to increase osteogenesis. Objectives: This study aims to assess the viability of osteoblast cells when exposed to the combination of SHED metabolites and two concentrations of EGCG, namely 10μM and 50μM. Methods: Osteoblast viability is examined with the 3-(4.5-dimethylthiazole-2-yl)2.5-diphenyl tetrazolium bromide (MTT) assays using an ELISA reader 570nm, and the absorbance value is converted to per cent form. CD50 is a parameter that indicates non-toxicity when the percentage value of living cells is more than 50%. Results: The percentage of living cells exceeded 50%, and statistically significant distinctions were observed among the control media, control cell groups, and the groups exposed to the combination of SHED metabolites and EGCG (p = 0.031). Conclusions: The viability of osteoblast cells exposed to the combination of SHED metabolites and EGCG 10µM, as well as the combination of SHED metabolites and EGCG 50µM, showed no toxicity. The combination of 10µM SHED metabolites and EGCG showed a higher osteoblast cell viability value than the combination of SHED metabolites and EGCG 50 µM.
Formulation and evaluation of Mesalamine mini-tablets in enteric-coated capsule for the treatment of ulcerative colitis using a factorial design approach
Authors: Pradyumna Donepudi , Srinivas Lankalapalli , Krishna Nallamothu
Published: October 2024

The Enteric Capsule Drug Delivery Technology (ECDDT) was designed to enable oral administration while ensuring complete enteric protection and swift release in the upper gastrointestinal (GI) tract, without the need for coatings. Current study used a 32factorial design (Stat-Ease Design Expert v12) to formulate a mini-tablet in an enteric-coated capsule to treat ulcerative colitis utilising ECDDT and mini-tablets. Mesalamine, an amino salicylate, was used as a model drug to study the effects of independent variables like HPMC K4M as a release retarding polymer at 10-20% and Crospovidone as a super disintegrant at 2-5% on in vitro drug release to meet desired Q points of dissolution. higher value of Tmax (10 Hours) and T1/2 (9 Hours) was observed for the Optimized formulation with Cmax value of (35.24 ± 0.45 ng/mL), AUC (0-48) (411.58 ± 1.45 hr.ng/mL) and Ke (0.077 ± 0.010 hr-1) it may be due to delayed release formulation.
Therapeutic Potential and Benefits of Moringa oleifera: An updated Overview
Authors: Satapathy Trilochan , Sahu Himanshu , Prasad Gupta Pushpa , Roy Amit
Published: October 2024

In this review, we have tried to explore the therapeutic potential and benefits of Moringa oleifera. Further investigation is required in this area, along with conducting clinical trials to assess any potential negative or toxic effects of Moringa oleifera in humans, ensuring its safe usage. This review delves into the intricate phytochemical composition, medicinal applications, and pharmacological characteristics of various components of this versatile tree. These parts have been found to have stimulating effects on the heart and circulation, as well as anti-tumor, anti-inflammatory, and antioxidant properties. The extensive range of pharmacological and botanical compound activities, as well as the traditional medicinal uses of Moringa oleifera, require a more thorough and comprehensive analysis. This will allow for a rigorous scientific examination of the documented literature, further justifying its effectiveness.
A Comprehensive Review on Redundancy usage of Animal models in Novel Drug testing
Authors: Verma Deepshikha , Namdeo K.P.
Published: October 2024

Millions of animals are used for laboratory research and development purposes each year; these living creatures endure suffering before being killed. Animal testing has other drawbacks in addition to bioethical concerns, such as high costs, the need for specialized labor, permission, and time commitment. As a result, Researchers have worked to make several substitute techniques that may replace using animals in tests. These techniques potentially save millions of animals' lives every year, in addition to providing precise findings. In- silico pharmacology methods are used in conjunction with computer and robotics research methodologies to develop alternative techniques for animal experimentation. In this context, several approaches are listed. Certain techniques are just as trustworthy as in-vivo animal models when it comes to precisely predicting the actions of drugs. These substitute techniques also have a number of benefits over using animals in experiments. Given that up to 90% of clinical trials fail, there is rising ethical concern over the use of excessive animals in drug research and development. The non-animal models described in this article have the potential to accelerate the medication delivery process at a faster pace. This review provides researchers and readers who are not aware of about predictive in- silico techniques a basic knowledge of the underlying theory. New advancements, software, acceptability hurdles, integrated techniques, and current applications are all covered, with links to more resources provided for each area. Furthermore, these alternative methods offer a variety of advantages over experimental animals.
ENVIRONMENTAL NOISE AND CARDIOVASCULAR DISEASES IN BULGARIA
Authors:   Department of Social Medicine and Health Management, Faculty of Public Health, Medical University - Pleven, Bulgaria., Tsanova Dima , Vitkova Tvetelina ,   Department of Hygiene, medical ecology, occupational diseases and disaster medicine, Faculty of Public Health, Medical University - Pleven, Bulgaria., Anov Atanas ,   Department of Hygiene, medical ecology, occupational diseases and disaster medicine, Faculty of Public Health, Medical University - Pleven, Bulgaria., Bankova Emilia ,   Department of Hygiene, medical ecology, occupational diseases and disaster medicine, Faculty of Public Health, Medical University - Pleven, Bulgaria.
Published: October 2024

Purpose: Noise has emerged as a leading environmental nuisance. Cardiovascular diseases rank first among the causes of death on a global scale and one of the possible effects of noise impact on the human organism. The study aims to analyze the level of noise pollution in Bulgaria and to measure its association with cardiovascular diseases. Methods: Data provided by the National Statistical Institute, Eurostat and other databases were used to analyze the noise pollution in Bulgaria. The 28 regions in Bulgaria were compared according to the proportion of surveyed points above permissible limits and the death rates due to cardiovascular diseases, /2022/. Data were statistically processed with SPSS v.26. Results: A positive fact is the absence of high values of noise levels in the range of 78-82 dB(A) and over 82 dB(A) and the decrease in the share of surveyed points with noise levels in this range during the analyzed period- from 27.3% in 2006 to 18.56% in 2022. The study found that almost all districts with the highest share of surveyed points above permissible limits have higher levels of death rate due to CVD. There is a positive moderate correlation between the share of surveyed points above permissible limits and the Death rate due to CVD - coefficient of Pearson is 0.423 (p=0.025). Conclusion: Cardiovascular diseases have a multifactorial genesis, but the reduction of noise in urban areas would help prevent these diseases.
ВЛИЯНИЕ СКРЕЩИВАНИЯ ЦИГАЙСКОЙ И ЭДИЛЬБАЕВСКОЙ ПОРОД НА ПРОДУКТИВНЫЕ КАЧЕСТВА ПОМЕСЕЙ
Authors: Косилов Владимир , Кадралиева Бакытканым , Абдурасулов Абдугани
Published: October 2024

В статье приводятся результаты оценки влияния  скрещивания  овец  цигайской породы с баранами эдильбаевской  породы на интенсивность роста помесного молодняка. Установлено, что апробируемый вариант скрещивания способствовал существенному повышению величины абсолютного и среднесуточного прироста живой массы, относительной скорости роста и коэффициента увеличения массы тела с возрастом у помесного молодняка. При этом кастрация баранчиков приводила к снижению интенсивности роста. Так у баранчиков цигайской породы  величина абсолютного прироста  живой массы за период выращивания от рождения до 12 мес. составляло 46,23 кг, валушков  этого генотипа - 42,49 кг, помесных баранчиков ½ эдильбай x ½ цигайская – 55,21 кг, помесных валушков – 50,81 кг при среднесуточном приросте живой массы соответственно 126,65 г, 151,26 г., 118,02 г, 139,20 г. При этом помесный молодняк превосходил чистопородных сверстников цигайской породы по относительной скорости роста за весь период выращивания от рождения до 12 мес. на 2,20-2,38 %, и уровню коэффициента увеличения живой массы с возрастом в конце выращивания в 12 мес. на 9,17-9,19 %. Кастрация баранчиков приводила к снижению относительной скорости роста за весь период выращивания от рождения до 12 мес. на 1,99-2,17 % и уровня коэффициента увеличения живой  массы в конце выращивания в 12 мес. на 8,27-8,29%.
Training of Trainers 4.0 Industri Kecil Menengah Furnitur Untuk Mendorong Transformasi Digital Dengan Teknologi Internet of Things
Authors: Kristianto Fesa Putra , Broto Taukhid Wisnu , Puspitaningsih Fitri Indah
Published: October 2024

The furniture industry in Central Java still faces various challenges, especially in adopting advanced technologies such as the Internet of Things and Industry 4.0. Many furniture SMEs still rely on manual or semi-manual production methods, which result in suboptimal product quality and production efficiency, making it difficult to compete in the global market. To address these challenges, the Community Service Program carried out by the Furniture Industry Business Management Study Program at Polytechnic of Furniture Industry and Wood Processing actively played a role through the Training of Trainers activity. This program aims to provide intensive training on the implementation of IoT and Industry 4.0 technologies to furniture SMEs in Central Java, focusing on developing practical skills and fostering digital transformation. Training of Trainers training involved Furniture Industry Business Management lecturers who possess specialized expertise in Industry 4.0 technologies. The training covered both theoretical and practical aspects, allowing participants to not only understand the concepts but also implement them in their work environments. Evaluation results showed a significant increase in the participants' understanding and skills in applying Industry 4.0 and Internet of Things technologies. A tangible example of the success of this training is PT. AST Indonesia, which successfully implemented Industry 4.0 and Internet of Things technologies in its production processes after participating in the Training of Trainers program. This success is concrete evidence that the training provided by Furniture Industry Business Management can contribute significantly to enhancing the competitiveness of furniture SMEs in the digital era, in line with the vision of "Making Indonesia 4.0.
Análisis crítico sobre las consecuencias de la legalización de la eutanasia en la sociedad
Authors: Costas Albarracín Juana Patrón , Grimaux Guadalupe
Published: October 2024

Este artículo tiene como objetivo presentar un análisis bioético claro de las consecuencias que tiene la legalización de la eutanasia sobre tres sectores: la sociedad, los enfermos y el personal médico. Para plasmarlo se desarrolla un análisis crítico a partir de un caso reciente de público conocimiento, además de una amplia revisión bibliográfica en torno a la temática. Así, se presenta de manera práctica y cercana el impacto de la legalización de la eutanasia. Se argumenta y concluye que el camino hacia una muerte digna no es la eutanasia, sino un acompañamiento activo e integral del paciente.