bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors affecting the economic burden of breast cancer in southern Iran
Authors: Jalali Faride Sadat , Seif Mozhgan , Jafari Abdosaleh , Zangouri Vahid , Keshavarz Khosro , Ravangard Ramin
Published: December 2023

Background

Breast cancer (BC) is the most common cancer in the world, and is associated with significant economic costs for patients and communities. Therefore, the information on the costs of the disease and the identification of its underlying factors will provide insights into designing effective interventions and reducing the costs. Thus, the present study aimed to identify the factors affecting the economic burden of breast cancer from all medical centers providing diagnostic and treatment services in southern Iran.

Methods

A list of factors affecting the economic burden of breast cancer was obtained based on the effective factors searched in the databases, including PubMed, ProQuest, Scopus, ISI Web of Science, SID, and Magiran, and the opinions of BC cancer specialists. Then, the data on 460 breast cancer patients was collected from March 2020 to March 2022. The relationship between the factors affecting Breast Cancer costs was analyzed using SPSS 13.0 software by the use of multiple regression analysis.

Results

The results of the multiple regression analysis showed that stages (P-value < 0.001), being an extreme user (p = 0.025), type of treatment center (P-value < 0.001), income (P-value < 0.001), chemotherapy side effects (P-value < 0.001), and distance to the nearest health center (P-value < 0.001) were important factors affecting the costs of breast cancer patients.

Conclusions

According to the results, encouraging people to undergo annual screenings, increasing insurance coverage, assuring the patients about the desirability and adequacy of the provided medical services, deploying specialists in chemotherapy centers (especially nutritionists) to recommend special diets, and establishing cancer diagnostic and treatment centers in high-population cities could help reduce the costs of breast cancer patients.
Evolution of economic burden of heart failure by ejection fraction in newly diagnosed patients in Spain
Authors: Escobar Carlos , Palacios Beatriz , Gonzalez Victoria , Gutiérrez Martín , Duong Mai , Chen Hungta , Justo Nahila , Cid-Ruzafa Javier , Hernández Ignacio , Hunt Phillip R. , Delgado Juan F.
Published: December 2023

Objective

To describe healthcare resource utilization (HCRU) and costs, in patients with newly diagnosed heart failure (HF) according to ejection fraction (EF) in Spain.

Methods

Retrospective cohort study that analyzed anonymized, integrated and computerised medical records in Spain. Patients with ≥ 1 new HF diagnosis between January 2013 and September 2019 were included and followed-up during a 4-year period. Rates per 100 person-years of HCRU and costs were estimated.

Results

Nineteen thousand nine hundred sixty-one patients were included, of whom 43.5%, 26.3%, 5.1% and 25.1% had HF with reduced, preserved, mildly reduced and unknown EF, respectively. From year 1 to 4, HF rates of outpatient visits decreased from 1149.5 (95% CI 1140.8–1159.3) to 765.5 (95% CI 745.9–784.5) and hospitalizations from 61.7 (95% CI 60.9–62.7) to 15.7(14.7–16.7) per 100 person-years. The majority of HF-related healthcare resource costs per patient were due to hospitalizations (year 1–4: 63.3–38.2%), followed by indirect costs (year 1–4: 12.2–29.0%), pharmacy (year 1–4: 11.9–19.9%), and outpatient care (year 1–4: 12.6–12.9%). Mean (SD) per patient HF-related costs decreased from 2509.6 (3518.5) to 1234.6 (1534.1) Euros (50% cost reduction). At baseline, 70.1% were taking beta-blockers, 56.3% renin-angiotensin system inhibitors, 11.8% mineralocorticoid receptor antagonists and 8.9% SGLT2 inhibitors. At 12 months, these numbers were 72.3%, 65.4%, 18.9% and 9.8%, respectively.

Conclusions

Although the economic burden of HF decreased over time since diagnosis, it is still substantial. This reduction could be partially related to a survival bias (sick patients died early), but also to a better HF management. Despite that, there is still much room for improvement.
Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus
Authors: Wang Wei , Shi Wei , Wang Yinglan , Yang Yane , Li Ping , Zeng Zhipeng , Hu Wenlong , Chen Yumei , Tang Donge , Dai Yong
Published: December 2023

Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue.
TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma
Authors: Zhou Yiran , Jin Jiabin , Ji Yuchen , Zhang Jiaqiang , Fu Ningzhen , Chen Mengmin , Wang Jun , Qin Kai , Jiang Yu , Cheng Dongfeng , Deng Xiaxing , Shen Baiyong
Published: December 2023

Background

Although the molecular features of pancreatic ductal adenocarcinoma (PDAC) have been well described, the impact of detailed gene mutation subtypes on disease progression remained unclear. This study aimed to evaluate the impact of different TP53 mutation subtypes on clinical characteristics and outcomes of patients with PDAC.

Methods

We included 639 patients treated with PDAC in Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine between Jan 2019 and Jun 2021. The genomic alterations of PDAC were analyzed, and the association of TP53 mutation subtypes and other core gene pathway alterations with patients’ clinical characteristics were evaluated by Chi-squared test, Kaplan-Meier method and Cox regression model.

Results

TP53 missense mutation was significantly associated with poor differentiation in KRASmut PDAC (50.7% vs. 36.1%, P = 0.001). In small-sized (≤ 2 cm) KRASmut tumors, significantly higher LNs involvement (54.8% vs. 23.5%, P = 0.010) and distal metastic rate (20.5% vs. 2.9%, P = 0.030) were observed in those with TP53 missense mutation instead of truncating mutation. Compared with TP53 truncating mutation, missense mutation was significantly associated with reduced DFS (6.6 [5.6–7.6] vs. 9.2 [5.2–13.3] months, HR 0.368 [0.200–0.677], P = 0.005) and OS (9.6 [8.0-11.1] vs. 18.3 [6.7–30.0] months, HR 0.457 [0.248–0.842], P = 0.012) in patients who failed to receive chemotherapy, while higher OS (24.2 [20.8–27.7] vs. 23.8 [19.0–28.5] months, HR 1.461 [1.005–2.124], P = 0.047) was observed in TP53missense cases after chemotherapy.

Conclusions

TP53 missense mutation was associated with poor tumor differentiation, and revealed gain-of-function properties in small-sized KRAS transformed PDAC. Nonetheless, it was not associated with insensitivity to chemotherapy, highlighting the neoadjuvant therapy before surgery as the potential optimized strategy for the treatment of a subset of patients.
Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges
Authors: Pang Zhi , Lu Man-man , Zhang Yu , Gao Yuan , Bai Jin-jin , Gu Jian-ying , Xie Lu , Wu Wei-zhong
Published: December 2023

Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed with an incredible diversity of T cell receptors (TCRs) that theoretically react to the variety of random mutations generated by tumor cells. The outcomes, however, of current clinical trials using TCR-T cell therapies are not very successful especially involving solid tumors. The therapy still faces numerous challenges in the efficient screening of tumor-specific antigens and their cognate TCRs. In this review, we first introduce TCR structure-based antigen recognition and signaling, then describe recent advances in neoantigens and their specific TCR screening technologies, and finally summarize ongoing clinical trials of TCR-T therapies against neoantigens. More importantly, we also present the current challenges of TCR-T cell-based immunotherapies, e.g., the safety of viral vectors, the mismatch of T cell receptor, the impediment of suppressive tumor microenvironment. Finally, we highlight new insights and directions for personalized TCR-T therapy.
Structural and Magnetic Properties of the B-Site-Ordered Double Perovskites Ln2NiTiO6 (Ln = La, Pr, and Nd)
Authors: Goto Masato , Okazaki Masato , Shimakawa Yuichi
Published: December 2023

Structural and magnetic properties of B-site-ordered double perovskites Ln2NiTiO6 (Ln = La, Pr, and Nd) were investigated. The charge formulas were revealed to be Ln23+Ni2+Ti4+O6, which gave a geometrically frustrated face-centered cubic lattice consisting of magnetic Ni2+ (S = 1) cations. In spite of the geometrical spin frustration of Ni2+ spins, the samples show an antiferromagnetic-like magnetic transition at temperatures TN close to their absolute values of the Weiss temperature θ, giving small frustration indices f = |θ|/TN ∼ 1. The small f values are considered to be due to some amount of anti-site disorder between Ni2+ and Ti4+ originating in the small valence difference. The suppression of magnetic ordering in the geometrically frustrated system is strongly affected by the B-site cation ordering in the double perovskites.
Narayana numbers as products of three repdigits in base g
Authors: Tiebekabe Pagdame , KAKANOU Kossi Richmond , Ben Yakkou Hamid
Published: December 2023

In this paper, we show that there are only finitely many Narayana's numbers which can be written as a product of three repdigits in base g with g >= 2. Moreover, for 2 <= g <= 10, we determine all these numbers.
Digitalisation of a National Metrology System
Authors: Slezák Michal , Halaj Martin
Published: December 2023

Purpose: This paper deals with the method of digitalisation of the authorisation process for verification of legally controlled measuring instruments, which is under the responsibility of the Slovak Office for Standards, Metrology and Testing, presents the legislative definition of the process and a description of the individual authorisation threads. Furthermore, the work deals with the method of process digitalisation, which can be applied analogously to other processes within the office.
Methodology/Approach: We have analysed the law on metrology and identified 26 processes suitable for digitalisation. These processes were analysed in more detail by flowcharts and process maps.
Findings: We have found that the most complex process in the national metrology system is the authorisation process, and therefore, we concluded that it will be the most appropriate process for the scope of digitalisation.
Research Limitation/implication: Our research is limited by the currently valid legal metrology regulations in the Slovak Republic.
Originality/Value of paper: Creating a universal methodology to define a strategy and implementing the digitalisation of the selected industry in specific national facts. The article can serve as a detailed and qualified background in the processes of specific implementation of national metrology system digital services in Slovakia.
A modified Delphi consensus statement on patellar instability: part I
Authors: Hurley Eoghan T. , Hughes Andrew J. , Savage-Elliott Ian , Dejour David , Campbell Kirk A. , Mulcahey Mary K. , Wittstein Jocelyn R. , Jazrawi Laith M.
Published: December 2023

Aims

The aim of this study was to establish consensus statements on the diagnosis, nonoperative management, and indications, if any, for medial patellofemoral complex (MPFC) repair in patients with patellar instability, using the modified Delphi approach.

Methods

A total of 60 surgeons from 11 countries were invited to develop consensus statements based on their expertise in this area. They were assigned to one of seven working groups defined by subtopics of interest within patellar instability. Consensus was defined as achieving between 80% and 89% agreement, strong consensus was defined as between 90% and 99% agreement, and 100% agreement was considered to be unanimous.

Results

Of 27 questions and statements on patellar instability, three achieved unanimous consensus, 14 achieved strong consensus, five achieved consensus, and five did not achieve consensus.

Conclusion

The statements that reached unanimous consensus were that an assessment of physeal status is critical for paediatric patients with patellar instability. There was also unanimous consensus on early mobilization and resistance training following nonoperative management once there is no apprehension. The statements that did not achieve consensus were on the importance of immobilization of the knee, the use of orthobiologics in nonoperative management, the indications for MPFC repair, and whether a vastus medialis oblique advancement should be performed.

Cite this article: Bone Joint J 2023;105-B(12):1259–1264.
Cementless metal-backed patellar components in primary total knee arthroplasty using an implant of modern design
Authors: Baker James F. , Nadar Arun C. , Jouflas Alex C. , Smith Langan S. , Sachdeva Shikha , Yakkanti Madhusudhan R. , Malkani Arthur L.
Published: December 2023

Aims

The use of cementless total knee arthroplasty (TKA) components has increased during the past decade. The initial design of cementless metal-backed patellar components had shown high failure rates due to many factors. The aim of this study was to evaluate the clinical results of a second-generation cementless, metal-backed patellar component of a modern design.

Methods

This was a retrospective review of 707 primary TKAs in 590 patients from a single institution, using a cementless, metal-backed patellar component with a mean follow-up of 6.9 years (2 to 12). A total of 409 TKAs were performed in 338 females and 298 TKAs in 252 males. The mean age of the patients was 63 years (34 to 87) and their mean BMI was 34.3 kg/m2 (18.8 to 64.5). The patients were chosen to undergo a cementless procedure based on age and preoperative radiological and intraoperative bone quality. Outcome was assessed using the Knee Society knee and function scores and range of motion (ROM), complications, and revisions.

Results

A total of 24 TKAs (3.4%) in 24 patients failed and required revision surgery, of which five were due to patellar complications (0.71%): one for aseptic patellar loosening (0.14%) and four for polyethylene dissociation (0.57%). A total of 19 revisions (2.7%) were undertaken in 19 patients for indications which did not relate to the patella: four for aseptic tibial loosening (0.57%), one for aseptic femoral loosening (0.14%), nine for periprosthetic infection (1.3%), one for popliteus impingement (0.14%), and four for instability (0.57%). Knee Society knee and function scores, and ROM, improved significantly when comparing pre- and postoperative values. Survival of the metal-backed patellar component for all-cause failure was 97.5% (95% confidence interval 94.9% to 100%) at 12 years.

Conclusion

The second-generation cementless TKA design of metal-backed patellar components showed a 97.5% survival at 12 years, with polyethylene dissociation from the metal-backing being the most common cause of patellar failure. In view of the increased use of TKA, especially in younger, more active, or obese patients, these findings are encouraging at mean follow-up of seven years.

Cite this article: Bone Joint J 2023;105-B(12):1279–1285.
KNEE ARTHROSCOPY: SHOULD KNEE ARTHROSCOPY SIMULATION BE PART OF THE TRAINING CURRICULUM IN THE UK?
Authors: Saghir R , Watson K , Martin A , Cohen A , Newman J , Rajput V
Published: December 2023

Introduction

Knee arthroscopy can be used for ligamentous repair, reconstruction and to reduce burden of infection. Understanding and feeling confident with knee arthroscopy is therefore a highly important skillset for the orthopaedic surgeon. However, with limited training or experience, furthered by reduced practical education due to COVID-19, this skill can be under-developed amongst trainee surgeons.

Methods

At a single institution, ten junior doctors (FY1 to CT2), were recruited as a part of a five, two-hour session, training programme utilising the Simbionix® ARTHRO Mentor knee arthroscopy simulator, supplemented alongside educational guidance with a consultant orthopaedic knee surgeon. All students had minimal to no levels of prior arthroscopic experience. Exercises completed included maintaining steadiness, image centring and orientation, probe triangulation, arthroscopic knee examination, removal of loose bodies and meniscectomy. Pre and post experience questionnaires and quantitative repeat analysis on simulation exercises were undertaken to identify levels of improvement.

Results

Comparing pre and post experience questionnaires significant improvements in levels of confidence were noted in the following domains: naming arthroscopic instruments, port positioning and insertion, recognising normal anatomy arthroscopically, holding and using arthroscopic instruments and assisting in a live theatre setting (p<0.05). Significant improvements were also noted in time taken to complete and distance covered in metres, of the simulated exercises on repeat performance (p<0.05).

Conclusion

Overall, with only five sessions under senior guidance, using a simulator such as the ARTHRO Mentor, significant improvements in both levels of confidence and skill can be developed even among individuals with no prior experience.
PROCESSO DE ENSINO-APRENDIZAGEM DO FUTEBOL NAS AULAS DE EDUCAÇÃO FÍSICA ESCOLAR
Authors: Santos de Jesus Caique , Santos Passos Costa Jessica , Aparecida Da Costa Nascimento Nayla , Alves Nogueira Souza Suzana , Leite Rodrigues Tainara
Published: December 2023

Este estudo trata de uma investigação científica acerca do processo de ensino-aprendizagem do futebol, pois existe a necessidade de maiores informações sobre a tematização do futebol na escola, além de buscar elementos pedagógicos a fim de evidenciar as estratégias utilizadas pelos professores durante as aulas. Objetivo: descrever, baseado na literatura científica, o processo de ensino-aprendizagem do futebol nas aulas de educação física escolar. Método: Trata-se de um artigo de revisão integrativa, com abordagem descritiva e natureza qualitativa. A seleção dos artigos se deu no período de fevereiro a junho de 2023, a busca foi feita nas bases de dados indexadas no Scientific Eletronic Library Online, Google Scholar e Biblioteca Virtual da Saúde. Resultados: Foram selecionados 6 artigos que abordavam os objetivos do estudo. Os artigos encontrados foram publicados no período de 2010 a 2023, todos com abordagem qualitativa. As estratégias didáticas utilizadas para ensinar o futebol nas aulas foram: tematização do conteúdo; valorização da opinião dos estudantes; planejamento das aulas de maneira diversificada e na perspectiva lúdica, além de trazer novas possibilidades sobre a compreensão da simbologia do esporte, oportunizando aos alunos a sensação de pertencimento e parte do processo de construção da aula. Conclusão: Há muitas discussões para alcançar uma didática de ensino na escola, não havendo uma “fórmula” certa, e assim proporcionando ao professor de Educação Física a utilização de diversas estratégias que melhor facilite o processo de aprendizagem dos estudantes.
Americanization of Rumi: The Impact of Coleman Barks’s Appropriative Translations
Authors: Artun F. Betul Cihan
Published: December 2023

Abstract: This article examines the ways in which the Sufi scholar-poet Jalal al-Din Rumi (d. 1273) is appropriated into a specific form of American religiosity through the intra-lingual “collaborative” translations of Coleman Barks. I argue that Barks’ attempt to reveal the universal message inherent in Rumi’s verses effectively de-Islamizes Rumi’s oeuvre and personality as his translation strategy entails elimination of particulars of Islamic culture and adaptation of the poems to the taste and sensitivities of the implied readers. In effect, Barks contributes to the Americanization of Rumi, which ultimately cast him as a “New Age guru” with romantic sensibilities.
The Sierra Nevada (California) Is a Relict Tropical Late Cretaceous Range: A Field Guide to the Evidence
Authors: Schaffer Jeffrey P.
Published: December 2023

ABSTRACT: The notion of late-Cenozoic uplift was implied in 1865 by Whitney, who assumed a buried bedrock canyon lay beneath the Table Mountain latite flow and above the modern Stanislaus River canyon, with the difference between the two longitudinal profiles suggesting post-latite uplift. However, only a series of buried bedrock ridges exists and no uplift is inferred. I briefly present thirty-three key sites of about three hundred remnants in the entire Sierra Nevada, from north of the Feather River south to the Kern River. These include Late Cretaceous strata, Eocene strata, Oligocene rhyolites, Mio-Pliocene andesites, and Quaternary basalts, some remnants on canyon floors but most on lower slopes, preserving topography at the time of deposition. I found no evidence of late-Cenozoic incision, which is required under the late-Cenozoic uplift paradigm. Instead, each site contains verifiable field evidence that challenges the uplift paradigm. Moreover, the results are consistent with the range having a common uplift history: the crest elevation, drainage topography, and relief developed in the Late Cretaceous, and only minor changes occurred in post-Eocene time. This supports uplift studies in the northern Sierra based on hydrogen and oxygen isotopes on auriferous deposits, and supports pediment ages of 40+ Ma in the southern Sierra. Uplift studies based on thermochronology and numerical modeling, on cave-sediment dating and its implied incision, and on significant denudation on benchlands cannot be reconciled with verifiable field evidence. Finally, migration of giant sequoias southwest into the Sierra Nevada was possible only from late in the Cretaceous, when the Nevadaplano came into existence and the range was high, negating any Sierran late-Cenozoic uplift paradigm.
Prokaryotic virus host prediction with graph contrastive augmentaion
Authors: Du Zhi-Hua , Zhong Jun-Peng , Liu Yun , Li Jian-Qiang
Published: December 2023

Prokaryotic viruses, also known as bacteriophages, play crucial roles in regulating microbial communities and have the potential for phage therapy applications. Accurate prediction of phage-host interactions is essential for understanding the dynamics of these viruses and their impacts on bacterial populations. Numerous computational methods have been developed to tackle this challenging task. However, most existing prediction models can be constrained due to the substantial number of unknown interactions in comparison to the constrained diversity of available training data. To solve the problem, we introduce a model for prokaryotic virus host prediction with graph contrastive augmentation (PHPGCA). Specifically, we construct a comprehensive heterogeneous graph by integrating virus-virus protein similarity and virus-host DNA sequence similarity information. As the backbone encoder for learning node representations in the virus-prokaryote graph, we employ LGCN, a state-of-the-art graph embedding technique. Additionally, we apply graph contrastive learning to augment the node representations without the need for additional labels. We further conducted two case studies aimed at predicting the host range of multi-species phages, helping to understand the phage ecology and evolution.
Silencing of topical proline hydroxylase domain 2 promotes the healing of rat diabetic wounds by phosphorylating AMPK
Authors: Xie Defu , Liu Mengchang , Lin Yingxi , Liu Xingke , Yan Hong
Published: December 2023

Background

For diabetic ulcers, the impaired response to hypoxia is a key feature associated with delayed healing. In the early phase of hypoxia, hypoxic signaling activates the AMPK system through direct phosphorylation of the PHD2 pathway, producing a significant endogenous hypoxic protective effect.

Methods

Twenty Sprague-Dawley (SD) rats were randomly divided into two groups: treatment (sh-PHD2) and control (sh-Control). Using lentiviral encapsulation of PHD2-shRNA and transfection, the silencing efficiency of PHD2 expression was verified in rat dermal fibroblasts (RDF) and in rat aortic endothelial cells (RAECs). Changes in the ability of RDF and RAECs to proliferate, migrate, and in the rate of ATP production were observed and then tested after inhibition of AMPK phosphorylation using dorsomorphin. The lentiviral preparation was injected directly into the wounds of rats and wound healing was recorded periodically to calculate the healing rate. Wounded tissues were excised after 14 days and the efficiency of PHD2 silencing, as well as the expression of growth factors, was examined using molecular biology methods. Histological examination was performed to assess CD31 expression and therefore determine effects on angiogenesis.

Results

Lentiviral-encapsulated PHD2-sh-RNA effectively suppressed PHD2 expression and improved the proliferation, migration, and ATP production rate of RDF and RAEC, which were restored to their previous levels after inhibition of AMPK. The rate of wound healing, vascular growth, and expression of growth factors were significantly improved in diabetic-model rats after local silencing of PHD2 expression.

Conclusion

Silencing of PHD2 promoted wound healing in diabetic-model SD rats by activating AMPK phosphorylation.
Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP
Authors: Ølnes Åsa Schawlann , Teigen Marianne , Laerdahl Jon K. , Leren Trond P. , Strøm Thea Bismo , Bjune Katrine
Published: December 2023

Background

Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters in plasma from high density lipoprotein (HDL) to very low density lipoprotein and low density lipoprotein. Loss-of-function variants in the CETP gene cause elevated levels of HDL cholesterol. In this study, we have determined the functional consequences of 24 missense variants in the CETP gene. The 24 missense variants studied were the ones reported in the Human Gene Mutation Database and in the literature to affect HDL cholesterol levels, as well as two novel variants identified at the Unit for Cardiac and Cardiovascular Genetics, Oslo University Hospital in subjects with hyperalphalipoproteinemia.

Methods

HEK293 cells were transiently transfected with mutant CETP plasmids. The amounts of CETP protein in lysates and media were determined by Western blot analysis, and the lipid transfer activities of the CETP variants were determined by a fluorescence-based assay.

Results

Four of the CETP variants were not secreted. Five of the variants were secreted less than 15% compared to the WT-CETP, while the other 15 variants were secreted in varying amounts. There was a linear relationship between the levels of secreted protein and the lipid transfer activities (r = 0.96, p<0.001). Thus, the secreted variants had similar specific lipid transfer activities.

Conclusion

The effect of the 24 missense variants in the CETP gene on the lipid transfer activity was mediated predominantly by their impact on the secretion of the CETP protein. The four variants that prevented CETP secretion cause autosomal dominant hyperalphalipoproteinemia. The five variants that markedly reduced secretion of the respective variants cause mild hyperalphalipoproteinemia. The majority of the remaining 15 variants had minor effects on the secretion of CETP, and are considered neutral genetic variants.
Formulación y optimización de nanopartículas lipídicas con chitosán para la administración de quercetina
Authors: Gallego Diego , Colino Clara Isabel
Published: December 2023

La quercetina posee numerosas actividades, tales como antioxidante, anticancerígena, cardioprotectora, etc., útiles para su uso terapéutico. Sin embargo, presenta una limitada biodisponibilidad debido a su baja solubilidad acuosa, lo que limita su uso farmacéutico. En este trabajo, se propuso la encapsulación de quercetina en liposomas recubiertos con chitosán. Se estudió la influencia del peso molecular del chitosán (ultrabajo, bajo y medio) y la relación fosfatidilcolina:chitosán (16:1, 8:1, 4:1) en el tamaño, el índice de polidispersión, eficacia de encapsulación y potencial zeta de las nanopartículas, obteniéndose valores para estos parámetros de 339,02-670,62 nm, 0,26 y 0,32, 43,5-59,3 % y 55,18-63,28 mV respectivamente. Posteriormente se seleccionó el chitosán de peso molecular bajo y una relación fosfatidilcolina:chitosán 16:1 para un estudio de liofilización de las nanopartículas evaluando el efecto de la temperatura de congelación (-20 ºC y -80 ºC) y el crioprotector empleado (lactosa, trehalosa y sacarosa) en la eficacia de encapsulación y la humedad residual. Las condiciones de congelación a -80 ºC y trehalosa como crioprotector evitaron en mayor medida la pérdida de la quercetina encapsulada.
Organic substrates in the development of camu-camuzeiro (Myrciaria dubia (H. B. K.) McVaugh) in the amazon region
Authors: Bronze Antonia Benedita da Silva , Brito Sinara de Nazaré Santana , Monteiro Harleson Sidney Almeida , Sena Ewerton Delgado , Da Silva Nayara Ferreira Barros , Pinheiro Valdeci Junior Fonseca , Abreu Layse Barreto de Almeida , Dias Rhuan Carlos Nascimento
Published: December 2023

Amazon is the largest tropical forest on the planet, it has a variety of plant species with emphasis on manyfruit trees, such as the camu-camuzeiro (Myrciaria dubia (H. B. K.) McVaugh), which occurs naturally on thebanks of rivers, lakes, lowlands and flooded forest of the Amazon. The objective of this study is to evaluate thedevelopment of camu-camuzeiro seedlings in different organic substrates. The experiment was conductedin the seedling production nursery of the Federal Rural University of Amazon. The experimental design wasentirely randomized, with ten treatments and five repetitions, each portion was represented by ten plants,totaling 500 seedlings. The substrates evaluated were: T1 - Humus; T2 - Humus + Bird manure; T3 - Humus + Bovinemanure; T4 - Humus + Açaí kernel; T5 - Humus + Chestnut shell; T6 - Humus + Chestnut shell + Poultry manure;T7 - Humus + Bovine manure + Chestnut shell; T8 - Humus + Açaí kernel + Poultry manure; T9 - Humus + Açaíkernel + Bovine manure; T10 - Commercial. The different substrates used influenced the development of camucamuzeiroseedlings evaluated at 180 days. The treatments with a substrate based on Humus (T1), Humus + Açaíkernel (T4), Humus + Chestnut shell (T5), Humus + Chestnut shell + Poultry manure (T6), Humus + Bovine manure +Chestnut shell (T7), Humus + Açaí Kernel + Bovine manure (T9) and the commercial substrate (T10) are the bestfor a satisfactory development of this crop in the production field.
La precariedad de la situación
Authors: Molina Cristian
Published: December 2023

Se trata de la Introducción al dossier Estudios situados sobre otras literaturas, en el que se reconceptualizan las categorías de otras literaturas y de conocimiento situado.
Estrategias discursivas proto‒feministas en la poesía engagé de Noémia de Sousa
Authors: Altamiranda Daniel
Published: December 2023

Noemia de Sousa llegó a ser una figura en las letras de Mozambique a pesar de haber producido una obra breve, fraguada en un período en que las luchas coloniales comenzaron a crecer en el pensamiento intelectual de sus contemporáneos. Por ello su manifestación artística, que mereció desde una crítica devastadora hasta los encomios con que fue considerada en los últimos años, se enriquece por la confluencia de elementos sumamente significativos: a la crítica colonial, agrega dos componentes indisolubles, su condición de negra y de ser mujer. Y la conciencia de ser esclava incluso del hombre negro, que a su vez es esclavo del blanco. En este trabajo, ofrecemos una presentación de las cuestiones en términos de los parámetros del feminismo, en este caso, en ciernes y de la poesía engagé o comprometida.
Parasitismo de Amblyomma aureolatum (Pallas, 1772) (Acari: Ixodidae) en humanos y determinación molecular de organismos rickettsiales y piroplasmas en el norte de Uruguay
Authors: Alvez Rodrigo , Felix María Laura , Queirolo Diego , Venzal José Manuel
Published: December 2023

Amblyomma aureolatum (Pallas, 1772) se distribuye en Sudamérica y posee importancia médica y veterinaria. En Uruguay se encuentra ampliamente distribuida parasitando vertebrados silvestres y domésticos y se la relaciona a casos de rangeliosis canina. El objetivo de este trabajo fue determinar la presencia de organismos rickettsiales y piroplasmas en A. aureolatum del norte de Uruguay. Para ello se recolectaron 117 ninfas y adultos de A. aureolatum sobre zorros, perros y vegetación, así como una sobre un humano. Se extrajo ADN de las garrapatas obtenidas de animales y vegetación para realizar diferentes PCR utilizando cebadores dirigidos a genes para la detección de ADN de organismos Rickettsiales (Anaplasmataceae, Rickettsiaceae y Midichloriaceae) así como protozoarios del Orden Piroplasmida. Como resultados se obtuvieron tres secuencias, una para el gen gltA con una identidad de entre 99,4 a 100% con Rickettsia bellii, otra para el gen 16S ARNr con un 100% de identidad con Candidatus Midichloria sp. y la restante con 100% de identidad con Rangelia vitalii para el gen 18S ARNr. Estos resultados corresponden a los primeros reportes de R. bellii para el país y de Ca. Midichloria sp. y R. vitalii en A. aureolatum. Además, se reporta el primer caso de A. aureolatum parasitando humanos en Uruguay.
Mujer, inmigración, escritura
Authors: Regazzoni Susanna
Published: December 2023

Este artículo presenta algunas ideas respecto al tema de la mujer en la literatura de migración, especialmente la noción de “escritoras migrantes”, algunos tópicos desarrollados en narrativa de migración, las implicancias de la elección de una lengua de la escritura y la consideración de la literatura de migración dentro de la literatura comparada.
mafias italianas y sus vínculos con la Argentina
Authors: Maggio Angel Leonardo
Published: December 2023

Reseña del libro Mafias italianas en Argentina. Reflexiones sobre los límites de lo pensable y lo decible de María Soledad Balsas. Prohistoria Ediciones, 2023.
Recorrido histórico-político de la participación de mujeres en Argentina. Continuidades y desafíos
Authors: Tula María Inés
Published: December 2023

Este trabajo presenta un recorrido sobre la forma en que se insertan las acciones afirmativas para la conformación de listas legislativas en Argentina, en otras palabras, el cupo femenino en la década del ‘90 y la paridad más recientemente. 

En la primera parte, se realiza un balance sobre cómo impactaron las cuotas de género en la participación política, en el acceso a la representación e integración del poder legislativo nacional, con especial atención en la Cámara de Diputados. En segundo lugar, se reflexiona sobre cómo se llega al debate y aprobación de la ley de paridad, considerando el contexto en el que se produce y las limitaciones que se presentaron. Finalmente, se plantean algunos desafíos que se pueden observar en la actualidad, dado que transitamos un proceso de consolidación pero en el que persisten muchas resistencias.
Examination of the Attitudes of Sports Science Students Towards Autism Spectrum Disorder in Terms of Various Variables
Authors: KARACAN DOĞAN Pınar , DOĞAN İsa , ÇETİNKAYALI Gürkan
Published: December 2023

This study aimed to examine the attitudes of sports science students towards Autism Spectrum Disorder (ASD) in the context of various variables. The research was conducted in a survey model. To determine the participants' attitudes towards Autism Spectrum Disorder, the "Autism Spectrum Disorder Attitudes Scale (ASDAS)" developed by Flood et al. (2013) and adapted to Turkish by Batum (2019) was employed as the data collection tool. Additionally, a 9-item personal information form was included in the data collection tool, addressing participants' gender, academic class, major, the presence of individuals with autism in their immediate surroundings, willingness to work with individuals with autism, participation in programs, seminars, or courses related to autism, knowledge about the educational settings and processes for individuals with autism, awareness of Autism Spectrum Disorder in society, and preferred educational environment for individuals with autism. The data collected from the participants were analyzed using SPSS-25 software. A total of 239 students, consisting of 89 females and 150 males, participated in the study. The results indicated significant differences in the attitudes of students towards Autism Spectrum Disorder concerning the gender variable and the knowledge sub-dimension of ASDAS, the desire to work with individuals with autism and the social attitude and personal distance sub-dimensions of ASDAS, knowledge about the educational settings and processes for individuals with autism and the personal distance sub-dimension of ASDAS, awareness of Autism Spectrum Disorder in society and the total score and knowledge sub-dimension of ASDAS, the major variable and the personal distance sub-dimension of ASDAS, and the preferred educational environment for individuals with autism and the social attitude and knowledge sub-dimensions of ASDAS. In conclusion, it was observed that attitudes towards Autism Spectrum Disorder are not solely determined by individuals' educational level or knowledge but are also influenced by social, cultural, and individual factors.
SYSTEMATIC MAPPING STUDY: THE USE OF TRANSPILERS
Authors: Belyakov K. V. , Datsun N. N.
Published: December 2023

A systematic mapping of the literature on the topic of transpiler use was conducted. Research questions addressing the research topic have been compiled. A search for publications narrating the topic of transpilers in various digital sources was conducted. The selection of unique and relevant publications was performed. A quantitative distribution of works by type of publication channel, geography, and quantitative composition of authors was performed. Based on the obtained sample of publications the answers to the research questions were obtained. The terms used in place of the term "Transpiler" were researched. The most common synonym turned out to be the term "Source-to-source compiler". The fields of application of transpiling were investigated. Most often transpilers were used for code generation, computation, and optimization purposes. The programming languages most commonly encountered in research were also examined. The most common programming languages were C/C++ and Python. It was also noted that JavaScript is never the source language of transpilation. Correlations between research questions were examined. A correlation was found between research questions of synonyms and fields of application, where the names transpiler and transcompiler are more often used in the field of code generation. A connection was also found between research questions of synonyms and programming languages, where transpilers used within the same programming language are more often referred to as source-to-source compiler. A growing trend in the number of studies on transpiler topics was demonstrated. The prospects of the work were also identified – the classification of programming languages by their level (low, high) and the study of correlation with other classifications.
METHOD OF INTERACTIVE DESIGN OF FUNCTIONAL MECHANICAL OBJECTS BASED ON FREE FORMS FOR RAPID PROTOTYPING
Authors: Vyatkin S. I. , Dolgovesov B. S.
Published: December 2023

The method of interactive design of functional mechanical objects is presented. Three-dimensional objects are free forms and their combinations with the use of perturbation functions. The method allows you to customize the selected mechanical design for the shape specified by the user. The parameterized mechanism, mechanical and functional constraints that define the functionality and provide an acceptable configuration are configured. An interface has been developed through which the user controls the placement of mechanical parts and the shape. Thanks to this, the user can design various variants of the shape design and synthesize mechanical components that can later be manufactured using rapid prototyping technology. The purpose of the proposed work is to develop functional objects based on mechanisms. Functional mechanical objects are represented by the shape and appearance of the structure, mechanical details and functions describing the shapes and mechanical architectures. The method does not require modeling all the properties from scratch, but allows you to reuse the existing mechanical design. It is simply reconfigured to the form selected by the user. That is, so that the mechanical design remains the same, and the geometric shapes change. This is important for rapid prototyping, when it is necessary to create several variations of some design. As a result, an approach has been implemented that ensures the implementation of low-level mechanical constraints. An approach of spatial relationships between form, mechanism and high-level functional goals is also proposed. The effectiveness of the method was tested by reconfiguring several mechanical structures to various geometric shapes for further manufacturing of the resulting functional objects.
Устойчивость и сходимость локально-одномерной схемы А. А. Самарского,
аппроксимирующей многомерное интегро-дифференциальное уравнение конвекции-диффузии
с неоднородными граничными условиями первого рода
Authors: Бештокова Зарьяна Владимировна , Beshtokova Zaryana Vladimirovna
Published: December 2023

Изучена первая начально-краевая задача для многомерного (по пространственным переменным)
интегро-дифференциального уравнения конвекции-диффузии.
Для приближенного решения поставленной задачи предложена локально-одномерная схема А. А. Самарского
с порядком аппроксимации $O(h^2+\tau)$.
Исследование единственности и устойчивости решения проводится с помощью метода энергетических неравенств.
Получены априорные оценки решения локально-одномерной разностной схемы, откуда следуют единственность решения,
непрерывная и равномерная зависимость решения от входных данных, а также сходимость решения схемы к решению
исходной дифференциальной задачи со скоростью, равной порядку аппроксимации разностной схемы.
Для двумерной задачи построен алгоритм численного решения, проведены численные расчеты тестовых примеров,
иллюстрирующие полученные в работе теоретические результаты.
In Silico DFT (Density Functional Theory) Study of Chemosensor Selectivity of 3-Oxo-3H-Benzo[f]chromen-2-Carboxylic Acid (ABKK) on Sodium Metal Ion Using FMO (Frontier Molecular Orbital) Analysis
Authors: Al-Anshori Jamaludin , Abror Ajar Faflul , Juliandri Juliandri , Safari Agus , Hidayat Ace T.
Published: December 2023

The chemosensor selectivity of 3-oxo-3H-benzo[f]chromen-2-carboxylic acid (ABKK) toward Na+ metal ionhas been successfully studied in silico using FMO (Frontier Molecular Orbital) analysis method. The geometry of the ABKK structure was optimized by the DFT (Density Functional Theory) method with a function/basis set: M06/6-31G (d, p). Afterward, the electronic properties of the ABKK structure before and after binding to sodium ion were analyzed and compared with the ABKK+other metal ion structures representing valence charges 1-3 and within the constraints of the basis set used. The results of geometry optimization showed that 1ABKK+Na+ has a more positive frequency/minima than 2ABKK+Na+ with interaction energies of 145 and 200.5 kcal/mol, respectively. Ignoring the role of solvents, FMO analysis revealed that the bandgap energy of fluorophore and receptor interactions (∆E LUMO Fl-Rs 1ABKK+Na+) and (∆E HOMO Fl-Rs 2ABKK+Na+) were 0.631 and 0.336 eV, correspondingly. In addition, the bandgap energy of fluorophore/∆E Fl 1ABKK+Na+ and 2ABKK+Na+ were calculated at 4.347 and 4.362 eV. Comparing those two types of bandgap energies with the bandgap belonging to ABKK+other metal ions, the excitation, and PET (Photoinduced Electron Transfer) processes were estimated to be relatively favorable experienced by 2ABKK+Na+. Finally, the selectivity of ABKK toward sodium metal ions from the computational calculations was relatively in agreement with the laboratory experimental results.
DIET RENDAH PROTEIN TERHADAP STATUS KESEHATAN PASIEN PENYAKIT GINJAL KRONIS (PGK): KAJIAN PUSTAKA
Authors: Nareswari Andayu , Haq Nabila Ainul , Kusumastuty Inggita
Published: December 2023

ABSTRAKLatar belakang: Peningkatan jumlah penderita penyakit ginjal kronis (PGK) yang disebabkan oleh beberapa faktor risiko. Untuk mengurangi kerja ginjal biasanya pasien diberikan beberapa pembatasan zat gizi yang dapat menyebabkan pasien dengan penyakit ginjal kronis mengalami malnutrisi energi dan protein yang jika dibiarkan justru membuat harapan hidup pasien menurun.Tujuan: Tujuan dari kajian pustaka ini adalah untuk menganalisis diet rendah protein yang digunakan pada pasien penyakit ginjal kronis memberikan efek yang baik dan kontraindikasi dari pemberian diet rendah protein, sehingga dapat memperbaiki status kesehatan pasienMetode : Penelitian menggunakan sistematik review dari 19 jurnal dan dipilih 5 jurnal berdasarkan kriteria inklusi dan esklusi terkait dengan penyakit gagal ginjal kronis.Hasil : Beberapa artikel telah membahas terkait diet rendah protein yang diberikan pada pasien, namun perlu ada penilaian status gizi pasien dan kecukupan energi yang dikonsumsi pasien yang akan diberikan pembatasan protein. Adanya beberapa zat gizi juga seperti kalium dan jenis protein yang berasal dari sumber hewani dan nabati yang berpengaruh alam pengaturan pola makan pasien PGK karena adanyarisiko malnutrisi hingga kematianKesimpulan: Pemberian diet rendah protein pada pasien PGK sebaiknya juga mempertimbangkan beberapa hal sesuai dengan kondisi pasien serta pemilihan bahan makanan yang disesuaikan dengan kebutuhan. Faktor pemenuhan zat gizi untuk pasien PGK dapat menentukan status kesehatan pasienKata kunci: diet rendah protein, PGK, status Kesehatan ABSTRACTIntroduction: The prevalence of chronic kidney disease has increased as a result of various risk factors, and nutritional therapy, such as a low protein diet, is commonly used to maintain glomerulus advancement, which can lead to malnutrition and shorten the patient's life span.Aim: The goal of this literature review is to determine whether a low protein diet used in patients with chronic kidney failure has a good effect and whether there are any contraindications to delivering a low protein diet to enhance the patient's health.Methode: 5 journals were chosen for the study from a systematic assessment of 19 journals based on inclusion and exclusion criteria for chronic renal failure.Result: A nutritional assessment of the patient's nutritional condition and the appropriateness of energy intake in patients who will be given protein restriction has been explored in several studies. Because of the risk of starvation and death, various minerals, such as potassium and other types of protein, have an impact on the diet of CKD patients.Conclusions: A low protein diet must take into account a number of factors, including the patient's health and the food elements they require. Patients' nutritional state might be used to determine their health status.Keywords: Low protein diet. Chronic kidney disease, health status