bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Identification of Fungal Species through Multiplex-qPCR to Determine Candidal Vulvovaginitis and Antifungal Susceptibility
Authors: Arrieta-Aguirre Inés , Menéndez-Manjón Pilar , Carrano Giulia , Diez Ander , Fernandez-de-Larrinoa Íñigo , Moragues María-Dolores
Published: November 2023

Vulvovaginal candidiasis (VVC) is a prevalent condition affecting women worldwide. This study aimed to develop a rapid qPCR assay for the accurate identification of VVC etiological agents and reduced azole susceptibility. One hundred and twenty nine vaginal samples from an outpatient clinic (Bilbao, Spain) were analyzed using culture-based methods and a multiplex qPCR targeting fungal species, which identified Candida albicans as the predominant species (94.2%). Antifungal susceptibility tests revealed reduced azole susceptibility in three (3.48%) isolates. Molecular analysis identified several mutations in genes associated with azole resistance as well as novel mutations in TAC1 and MRR1 genes. In conclusion, we developed a rapid multiplex qPCR assay that detects C. albicans in vulvovaginal specimens and reported new mutations in resistance-related genes that could contribute to azole resistance.
Staged Treatment of Posttraumatic Tibial Osteomyelitis with Rib Graft and Serratus Anterior Muscle Autografts—Case Report
Authors: Anglitoiu Bogdan , Abu-Awwad Ahmed , Patrascu Jenel-Marain , Abu-Awwad Simona-Alina , Dinu Anca Raluca , Totorean Alina-Daniela , Cojocaru Dan , Sandesc Mihai-Alexandru
Published: November 2023

Osteomyelitis of the tibia is a challenging condition, particularly when it occurs as a result of trauma. This abstract presents a case study detailing the successful staged treatment of posttraumatic tibial osteomyelitis utilizing a unique combination of rib graft and serratus anterior muscle. This medical abstract presents a case study of a 52-year-old male with a history of heavy smoking and obliterating arteriopathy of the lower limbs. The patient sustained a traumatic open fracture classified as Type IIIA Gustilo Anderson involving one-third of the distal right tibia diaphysis, with an associated right fibular malleolus fracture. The treatment approach comprised multiple stages, focusing on wound management, infection control, and limb salvage. The initial stage involved the application of an external fixation device in the emergency setting. Seven days later, an osteosynthesis procedure was performed using a Kuntscher nail and wire cerclage. However, complications emerged, with wound dehiscence and purulent secretion observed at 14 days postsurgery. Subsequently, secondary suturing was carried out at the 20-day mark. The second stage of the treatment involved implant removal, wide excisional debridement, pulse lavage, osteoclasia, and relaxation of the peroneal malleolus. A monoplane external fixation system was applied. As a part of postoperative care, aspiration therapy with a vacuum pump was administered, along with a 10-day course of vancomycin according to the antibiogram. Positive clinical signs of healing were noted, and sterile cultures confirmed the results. The third stage of the intervention focused on grafting the osteo-muscular defect, utilizing autografts from the rib and serratus anterior muscle. The external fixator was maintained in place during this phase. In the fourth and final stage, after an 8-week integration period of the musculocutaneous flap, the external fixator was removed, and internal fixation was accomplished with a blocked Less Invasive Stabilization System (LISS) plate inserted using the Minimally Invasive Plate Osteosynthesis (MIPO) technique. This case underscores the significance of a multistage approach in managing complex limb injuries, emphasizing the importance of timely intervention, infection control, and innovative techniques for limb salvage and restoration of function.
Direct Comparative Analysis of a Pharmacogenomics Panel with PacBio Hifi® Long-Read and Illumina Short-Read Sequencing
Authors: Barthélémy David , Belmonte Elodie , Pilla Laurie Di , Bardel Claire , Duport Eve , Gautier Veronique , Payen Léa
Published: November 2023

Background: Pharmacogenetics (PGx) aims to determine genetic signatures that can be used in clinical settings to individualize treatment for each patient, including anti-cancer drugs, anti-psychotics, and painkillers. Taken together, a better understanding of the impacts of genetic variants on the corresponding protein function or expression permits the prediction of the pharmacological response: responders, non-responders, and those with adverse drug reactions (ADRs). Objective: This work provides a comparison between innovative long-read sequencing (LRS) and short-read sequencing (SRS) techniques. Methods and Materials: The gene panel captured using PacBio HiFi® sequencing was tested on thirteen clinical samples on GENTYANE’s platform. SRS, using a comprehensive pharmacogenetics panel, was performed in routine settings at the Civil Hospitals of Lyon. We focused on complex regions analysis, including copy number variations (CNVs), structural variants, repeated regions, and phasing-haplotyping for three key pharmacogenes: CYP2D6, UGT1A1, and NAT2. Results: Variants and the corresponding expected star (*) alleles were reported. Although only 38.4% concordance was found for haplotype determination and 61.5% for diplotype, this did not affect the metabolism scoring. A better accuracy of LRS was obtained for the detection of the CYP2D6*5 haplotype in the presence of the duplicated wild-type CYP2D6*2 form. A total concordance was performed for UGT1A1 TA repeat detection. Direct phasing using the LRS approach allowed us to correct certain NAT2 profiles. Conclusions: Combining an optimized variant-calling pipeline and with direct phasing analysis, LRS is a robust technique for PGx analysis that can minimize the risk of mis-haplotyping.
Do We Need Different Urban Green Spaces Now? A Case Study of Preferences during Pandemics
Authors: Misiune Ieva
Published: November 2023

The role of public urban green spaces (UGSs) in providing various ecosystem services, especially those related to the physical and mental health of city dwellers, has increased during the COVID-19 pandemic. While research has analyzed shifts in UGS visitation and changes in people’s attitudes, there remains a noticeable gap in our understanding of the necessary adaptations required within UGS environments. This paper presents the survey results of Vilnius city residents (Lithuania) conducted in the final days of the quarantine in 2021 and discusses the findings in the broader context of other studies. The survey is centered on preferences for UGS qualities clustered into four groups. The results provide empirical evidence that UGS users highly prioritize ergonomic and ecological characteristics related to comfort and naturalness. However, the preferences differ between those who live close to UGS and those who live further away. In contrast, aesthetic and social qualities are of relatively lesser significance for all. Similar preferences have been identified in international studies, underscoring the global nature of this phenomenon that urban planners must consider when designing or enhancing local UGS.
Mitigating Soil Erosion through Biomass-Derived Biochar: Exploring the Influence of Feedstock Types and Pyrolysis Temperature
Authors: Wani Owais Ali , Akhter Farida , Kumar Shamal Shasang , Babu Subhash , Kanth Raihana Habib , Mir Shakeel Ahmad , Mahdi Syed Sheraz , Malik Abdul Raouf , Bangroo Shabir , Gaafar Abdel-Rhman Z. , Popescu Simona M. , Rathore Sanjay Singh
Published: November 2023

Soil erosion is one of the major emerging threats to the Himalayan ecosystem. There is a dearth of diverse, cost-effective erosion control measures in the region. In the Himalayan region, where agriculture plays a pivotal role in local livelihoods and environmental stability, the management of soil erosion is of paramount importance. Hence, this study investigates the impact of biochar application on soil erosion and its related indices in the temperate Himalayas of India. This study employs a combination of physicochemical analysis and field experiments to assess the influence of biochar on soil erodibility. The research objectives include an examination of the influence of different temperature pyrolyzed biomasses and varying application rates on soil erodibility indices, viz., dispersion ratio (DR), percolation ratio (PR), clay ratio (CR), erosion ratio (ER), and mean weight diameter (MWD), considering two distinct fertilizer regimes. This study yielded quantitative results that shed light on the impact of various soil amendments and application rates on soil erodibility in the temperate Himalayas. Results showed that the mean values of the DR exhibited by amendment levels NB, AB400, AB600, RAC, DW400, DW600, and RDW were 0.37, 0.35, 0.51, 0.44, 0.51, 0.47, and 0.91, respectively. The mean values of DR for different amendment levels varied, with RDW exhibiting the highest erodibility at 0.91, while DW400 and DW600 demonstrated less soil disturbance, making them promising choices for soil erosion mitigation. Notably, the application of pyrolyzed weed residue improved soil erodibility, whereas AB600 resulted in increased soil erosion due to aggregate disintegration, as indicated by the MWD. Aquatic weed residues and apple wood chips applied without pyrolysis increased the soil erodibility, while pyrolyzed residues improved soil erodibility. The DR was 0.41 at the high application rate, 0.48 at the medium rate, and 0.61 at the low application rate. Among application rates, low rates (1 t ha−1) had the highest DR, followed by medium rates (2 t ha−1) and high rates (3 t ha−1). The no-fertilizer level exhibited higher DR (0.49) compared to the fertilized level (0.38). Results inferred that the application of AB400 °C at 3 t ha−1 can be adopted to minimize soil erosion and maintain ecological security in the temperate Himalayas.
Using Machine Learning to Identify the Relationships between Demographic, Biochemical, and Lifestyle Parameters and Plasma Vitamin D Concentration in Healthy Premenopausal Chinese Women
Authors: Wang Chun-Kai , Chang Ching-Yao , Chu Ta-Wei , Liang Yao-Jen
Published: November 2023

Introduction: Vitamin D plays a vital role in maintaining homeostasis and enhancing the absorption of calcium, an essential component for strengthening bones and preventing osteoporosis. There are many factors known to relate to plasma vitamin D concentration (PVDC). However, most of these studies were performed with traditional statistical methods. Nowadays, machine learning methods (Mach-L) have become new tools in medical research. In the present study, we used four Mach-L methods to explore the relationships between PVDC and demographic, biochemical, and lifestyle factors in a group of healthy premenopausal Chinese women. Our goals were as follows: (1) to evaluate and compare the predictive accuracy of Mach-L and MLR, and (2) to establish a hierarchy of the significance of the aforementioned factors related to PVDC. Methods: Five hundred ninety-three healthy Chinese women were enrolled. In total, there were 35 variables recorded, including demographic, biochemical, and lifestyle information. The dependent variable was 25-OH vitamin D (PVDC), and all other variables were the independent variables. Multiple linear regression (MLR) was regarded as the benchmark for comparison. Four Mach-L methods were applied (random forest (RF), stochastic gradient boosting (SGB), extreme gradient boosting (XGBoost), and elastic net). Each method would produce several estimation errors. The smaller these errors were, the better the model was. Results: Pearson’s correlation, age, glycated hemoglobin, HDL-cholesterol, LDL-cholesterol, and hemoglobin were positively correlated to PVDC, whereas eGFR was negatively correlated to PVDC. The Mach-L methods yielded smaller estimation errors for all five parameters, which indicated that they were better methods than the MLR model. After averaging the importance percentage from the four Mach-L methods, a rank of importance could be obtained. Age was the most important factor, followed by plasma insulin level, TSH, spouse status, LDH, and ALP. Conclusions: In a healthy Chinese premenopausal cohort using four different Mach-L methods, age was found to be the most important factor related to PVDC, followed by plasma insulin level, TSH, spouse status, LDH, and ALP.
Correlation of the Pro-Inflammatory Cytokines IL-1β, IL-6, and TNF-α, Inflammatory Markers, and Tumor Markers with the Diagnosis and Prognosis of Colorectal Cancer
Authors: Florescu Dan Nicolae , Boldeanu Mihail-Virgil , Șerban Robert-Emmanuel , Florescu Lucian Mihai , Serbanescu Mircea-Sebastian , Ionescu Mihaela , Streba Liliana , Constantin Cristian , Vere Cristin Constantin
Published: November 2023

Colorectal cancer (CRC) remains one of the most important global health problems, being in the top 3 neoplasms in terms of the number of cases worldwide. Although CRC develops predominantly from the adenoma–adenocarcinoma sequence through APC gene mutations, in recent years, studies have demonstrated the role of chronic inflammation in this neoplasia pathogenesis. Cytokines are important components of chronic inflammation, being some of the host regulators in response to inflammation. The pro-inflammatory cytokines IL-1β, IL-6, and TNF-α are involved in tumor cell proliferation, angiogenesis, and metastasis and seem to strengthen each other’s mode of action, these being stimulated by the same mediators. In our study, we collected data on 68 patients with CRC and 20 healthy patients from the Gastroenterology Department of Craiova County Emergency Clinical Hospital, who were assessed between January 2022 and February 2023. The main purpose of this study was to investigate the correlation between increased plasma levels of the cytokines and the extent of the tumor, lymph nodes, and metastasis—(TNM stage), as well as the patients’ prognoses. We also compared the plasma levels of cytokines and acute inflammatory markers, namely, the erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and fibrinogen, along with the tumor markers, carcinoembryonic antigen (CEA) and carbohydrate antigen 19.9 (CA 19.9), in CRC patients. We showed that all the pro-inflammatory cytokines studied had higher levels in patients with CRC in comparison with the control group. We also showed that the acute inflammatory markers of erythrocyte sedimentation rate, C-reactive protein, and fibrinogen, and the tumor markers of CEA and CA 19.9 can be useful in diagnosis and prognosis in patients with CRC. Considering the association between pro-inflammatory cytokines and CRC, the development of new targeted therapies against IL-1β, IL-6, and TNF-α can improve patient care and the CRC survival rate.
Collision Tumors of the Colon and Peritoneum: Signet-Ring Cell Carcinoma and Granular Cell Tumor
Authors: Lazureanu Dorela-Codruta , Anderco Denisa , Dema Sorin , Jurescu Aura , Cornea Remus , Vita Octavia , Tunescu Bogdan , Taban Sorina
Published: November 2023

Collision tumors, although rare, characterized by two distinctive (morphological, as well immunohistochemical) and spatially independent tumor components at the same location, are always puzzling for clinicians, pathologists, and patients because they do not fit into the usual approaches, being neither diagnostic nor therapeutic. Reviewing the specialized literature, to date, collision tumors have been reported in multiple locations such as the skin, esophagus, stomach, intestine, liver, kidney, bladder, adrenal gland, or thyroid. We report a case of coexistence at the same site of a malignant tumor of the ascending colon and a benign tumor emerging from the peritoneal lining, initially thought by the surgeon to be right-sided serosal carcinomatosis. But histopathological examination reveals that those multiple serosal nodules were benign granular cell tumors that have collided with highly aggressive transparietal signet-ring colon carcinoma. These results put the patient’s prognosis and therapeutic strategy in a different light than the clinical and intraoperative evaluation.
Poorly Differentiated Cutaneous Squamous Cell Carcinoma (cSCC) or Lymphoepithelioma-like Carcinoma of the Skin (LELCS) with Squamous Pearls: A Case Presentation with Emphasis on Histomorphological Features and Classification Debates
Authors: Maniglio Sonia , Cazzato Gerardo , Caporusso Concetta , Colagrande Anna , Nacchiero Eleonora , Maruccia Michele , Valerio Jacqueline , Maiorano Eugenio , Resta Leonardo , Marzullo Andrea , Giudice Giuseppe , Ingravallo Giuseppe
Published: November 2023

Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare primary skin cancer, with an annual incidence of 1/100,000 and about 85 cases published in the literature. It is considered the cutaneous counterpart of undifferentiated nasopharyngeal carcinoma (UNC, Schmincke–Regaud tumor) but has no association with EBV. We present an interesting case with features of LELCS in a 93-year-old man, right frontal–orbital region, diagnosed histologically and with immunohistochemical features. We also emphasize contrasting morphologic features for correct nosographic classification and address current issues, suggesting potential insights. Finally, we briefly reviewed other cases described in the literature.
Role of Heart Rate Variability in the Association between Myocardial Infarction Severity and Post-Myocardial Infarction Distress
Authors: Dyab Reham , Zuccarella-Hackl Claudia , Princip Mary , Sivakumar Sinthujan , Meister-Langraf Rebecca E. , Znoj Hansjörg , Schmid Jean-Paul , Barth Jürgen , Schnyder Ulrich , von Känel Roland , Gidron Yori
Published: November 2023

Objective: Myocardial infarction (MI) results in mental health consequences, including depression and post-traumatic stress disorder (PTSD). The risk and protective factors of such mental consequences are not fully understood. This study examined the relation between MI severity and future mental health consequences and the moderating role of vagal nerve activity. Methods: In a reanalysis of data from the Myocardial Infarction-Stress Prevention Intervention (MI-SPRINT) study, 154 post-MI patients participated. MI severity was measured by the Killip Scale and by troponin levels. Depression and PTSD symptoms were assessed with valid questionnaires, both at 3 and 12 months. Vagal nerve activity was indexed by the heart rate variability (HRV) parameter of the root-mean square of successive R-R differences (RMSSD). Following multivariate analyses, the association between MI severity and distress was examined in patients with low and high HRV (RMSSD = 30 ms). Results: In the full sample, the Killip index predicted post-MI distress only at 3 months, while troponin predicted distress at 3- and 12-months post-MI. However, HRV moderated the effects of the Killip classification; Killip significantly predicted symptoms of depression and PTSD at 3- and 12-months post-MI, but only in patients with low HRV. Such moderation was absent for troponin. Conclusion: MI severity (Killip classification) predicted post-MI depression and PTSD symptoms, but only in patients with low HRV, suggesting that the vagal nerve is a partial protective (moderating) factor in the relation between Killip score and post-MI distress.
Hepatocellular Carcinoma: Optimal Radiological Evaluation before Liver Transplantation
Authors: Dioguardi Burgio Marco , Garzelli Lorenzo , Cannella Roberto , Ronot Maxime , Vilgrain Valérie
Published: November 2023

Liver transplantation (LT) is the recommended curative-intent treatment for patients with early or intermediate-stage hepatocellular carcinoma (HCC) who are ineligible for resection. Imaging plays a central role in staging and for selecting the best LT candidates. This review will discuss recent developments in pre-LT imaging assessment, in particular LT eligibility criteria on imaging, the technical requirements and the diagnostic performance of imaging for the pre-LT diagnosis of HCC including the recent Liver Imaging Reporting and Data System (LI-RADS) criteria, the evaluation of the response to locoregional therapy, as well as the non-invasive prediction of HCC aggressiveness and its impact on the outcome of LT. We will also briefly discuss the role of nuclear medicine in the pre-LT evaluation and the emerging role of artificial intelligence models in patients with HCC.
Do We Perform Systematic Literature Review Right? A Scientific Mapping and Methodological Assessment
Authors: Azarian Mathew , Yu Hao , Shiferaw Asmamaw Tadege , Stevik Tor Kristian
Published: November 2023

Background: Systematic literature review (SLR) is increasingly utilized to maximize the element of rigor and minimize the individual bias of research synthesis. An analysis of the Web of Science (WoS) database indicates that 90% of the literature review studies using SLR have been published between 2012 and 2022. However, this progressive agenda is impaired by the lack of methodological consistency and rigorousness. To fill this gap, this paper aims at mapping the theoretical comprehension and practices of SLR and providing a stepwise approach to employing such a framework. Methods: A comprehensive narrative review is used in this paper to analyze the studies concerning the literature review typology and the structural assessment of the SLR. Furthermore, the methodological approach of the literature review studies that adopted the SLR and were published in the Logistics journal is assessed across a set of vital criteria associated with conducting an SLR. Results: There is a concrete link between the purpose of a review, i.e., to describe, test, extend, or critique, and the literature review type. There are 17 distinct literature review types, e.g., a narrative review, a bibliometric analysis, etc., which must be justified meticulously regardless of the SLR. The ambiguity in conceiving the SLR either as a toolkit or a review type, the lack of justification regarding the review purpose and type, and vague conceptual distinguishment between the bibliometric analysis, as a distinct review type, and the SLR framework, are only a few of the shortcomings observed in the analyzed papers. Conclusions: Given the significant role of SLR in elevating the element of rigor within the literature review studies, it is deemed essential to employ this framework by paying attention to two holistic factors: (1) theoretical distinction between the literature review purpose, the literature review type, and the SLR; (2) strict adherence to the SLR procedure with a high degree of accuracy and explicitness.
Simple Deconvolution Models for Evaluating the True Microhardness of Thin Nanostructured Coatings Deposited via an Advanced Physical Vapor Deposition Technique
Authors: Kanders Uldis , Kanders Karlis , Jansons Ernests , Lungevics Janis , Sirants Raimonds , Leitans Armands , Boiko Irina
Published: November 2023

This article discusses the micromechanical properties and true microhardness determination of nanostructured tribological coatings (NTCs) based on a multilayered alternating nitride/carbonitride bilayer substructure for transition metals. The constituent nitride/carbonitride bilayers in the superlattice structure of the NTC were alloyed with refractory metals, denoted as Me = Me1 or Me2= Cr, Hf, Nb, W, and Zr. The resulting NTC coatings were deposited onto 100Cr6 steel substrates using an advanced physical vapor deposition (PVD) technique, referred to here as high-power ion-plasma magnetron sputtering (HiPIPMS). The comprising crystalline nanometer-scale TiAlSiMe1-N/TiMe2-CN nanoparticles strengthened by Me additives significantly increased the NTC microhardness to over 3200 HV. The primary focus of this research was to determine the true microhardness of the NTC film samples. The apparent microhardness (Ha) of the film/substrate system for various NTC samples was measured during microindentation testing using the Vickers method. Nine NTC samples were tested, each generating a corresponding microindentation dataset containing between 430 and 640 imprints, depending on the specific NTC sample. These datasets were analyzed using three distinct empirical approaches: (i) the inverse power-law model (IPL-Model), (ii) the sigmoid-like decay model (SLD-Model), and (iii) the error function model (ERF-Model). The observed solid correlation between the proposed models and experiments suggests that the true microhardness estimates (Hf) obtained through the empirical mathematical modeling approach are reliable.
An Inverse Sturm–Liouville-Type Problem with Constant Delay and Non-Zero Initial Function
Authors: Buterin Sergey , Vasilev Sergey
Published: November 2023

We suggest a new statement of the inverse spectral problem for Sturm–Liouville-type operators with constant delay. This inverse problem consists of recovering the coefficient (often referred to as potential) of the delayed term in the corresponding equation from the spectra of two boundary value problems with one common boundary condition. The previous studies, however, focus mostly on the case of zero initial function, i.e., they exploit the assumption that the potential vanishes on the corresponding subinterval. In the present paper, we waive that assumption in favor of a continuously matching initial function, which leads to the appearance of an additional term with a frozen argument in the equation. For the resulting new inverse problem, we pay special attention to the situation when one of the spectra is given only partially. Sufficient conditions and necessary conditions on the corresponding subspectrum for the unique determination of the potential are obtained, and a constructive procedure for solving the inverse problem is given. Moreover, we obtain the characterization of the spectra for the zero initial function and the Neumann common boundary condition, which is found to include an additional restriction as compared with the case of the Dirichlet common condition.
A New Conditional Privacy-Preserving Certificateless Aggregate Signature Scheme in the Standard Model for VANETs
Authors: Yuan Beibei , Huang Hui , Wu Chenhuang
Published: November 2023

Vehicular Ad Hoc Networks (VANETs) take moving vehicles and transport facilities as nodes to form mobile networks through wireless communication technology. Its application increases traffic safety and promotes the development of intelligent transport. However, VANETs have security concerns in data transmission. Fortunately, aggregate signature schemes can enhance security and efficiency in the VANETs. Nevertheless, some aggregated signature schemes for VANETs still have security concerns. In this paper, we conduct a security analysis of a conditional privacy-preserving CLAS scheme for VANETs proposed recently. The analysis reveals that the scheme exhibits vulnerabilities to the KGC attack and public key replacement attack. We propose an improved scheme to fix security vulnerabilities in response to these issues. Subsequently, formal and informal security assessments are conducted for the improved scheme, demonstrating that it fulfills security requisites. Furthermore, performance assessment demonstrates the practical viability of the refined scheme.
Equilibrium Strategy of Production and Order in a Two-Echelon Supply Chain with Demand Information Updates and Capacity Restriction
Authors: Peng Jiawu , Zhao Yue , Dai Lili
Published: November 2023

This paper studies production-and-order strategies under three production systems in which the supplier’s production quantity is constrained by the upfront preparations of capacity due to a long production season. The newsvendor-like retailer may make an advance order at the beginning of the production season, relying on early demand information, or a delay order at the end of the production season, depending on the updated demand information. In two special cases of perfect and imperfect demand information updates, this paper analytically derives the optimal decision equilibrium of a supplier-led Stackelberg game for three production-and-order strategies: (1) advance order under single regular production, (2) delay order under single emergency production and (3) delay order under two-mode production. In the case of perfect information updates, all three strategies likely become the equilibrium strategies that depend on the instant wholesale price and on the production cost for emergency production. In the case of imperfect information updates, the strategy of advance orders under regular production represents the unique equilibrium of the supply chain. Furthermore, the effect of general demand information updates on the equilibrium strategy is analyzed. Counterintuitively, the research results show that the retailer is more profitable with imperfect information updates than with perfect information updates when a high instant wholesale price is charged. In sharp contrast to previous studies, where the supplier always benefits from a two-mode production system due to its flexibility, our results indicate that the supplier would prefer a single regular production system when the production cost under emergency production is large, or the quality of demand information is high. Numerical examples verify our theoretical results.
Representation of Fractional Operators Using the Theory of Functional Connections
Authors: Mortari Daniele
Published: November 2023

This work considers fractional operators (derivatives and integrals) as surfaces f(x,α) subject to the function constraints defined by integer operators, which is a mandatory requirement of any fractional operator definition. In this respect, the problem can be seen as the problem of generating a surface constrained at some positive integer values of α for fractional derivatives and at some negative integer values for fractional integrals. This paper shows that by using the Theory of Functional Connections, all (past, present, and future) fractional operators can be approximated at a high level of accuracy by smooth surfaces and with no continuity issues. This practical approach provides a simple and unified tool to simulate nonlocal fractional operators that are usually defined by infinite series and/or complicated integrals.
Research on Time-Varying Meshing Stiffness of Marine Beveloid Gear System
Authors: Wen Jianmin , Yao Haoyu , Yan Qian , You Bindi
Published: November 2023

Beveloid gears have the advantages of compensating for axial error, providing smooth transmission, and eliminating turning error. Therefore, they are widely used in applications that require high transmission accuracy and stability. However, research on calculating the time-varying meshing stiffness of beveloid gears is still limited, and there is an urgent need to propose a method that can calculate the meshing stiffness of beveloid gears quickly and accurately. We first established the tooth profile expressions, assuming a pair of beveloid gears meshing with the same rack, and the contact line equations of parallel axis beveloid gear pairs were derived. Next, we analyzed the contact process of beveloid gears. We propose an analytical algorithm based on the slicing method to calculate the meshing stiffness of helical gears, straight beveloid gears, and helical beveloid gears. Then, the influence of different parameters on the meshing stiffness of helical beveloid gears was analyzed by changing the respective parameters. Finally, the finite element method (FEM) was used to verify the correctness of the analytical results, and then the errors were analyzed. The study demonstrates that the results obtained from the analytical algorithm we proposed have the same magnitude as those obtained by the FEM for the time-varying meshing stiffness calculation of beveloid gears.
A Visually Inspired Computational Model for Recognition of Optic Flow
Authors: Li Xiumin , Lin Wanyan , Yi Hao , Wang Lei , Chen Jiawei
Published: November 2023

Foundation models trained on vast quantities of data have demonstrated impressive performance in capturing complex nonlinear relationships and accurately predicting neuronal responses. Due to the fact that deep learning neural networks depend on massive amounts of data samples and high energy consumption, foundation models based on spiking neural networks (SNNs) have the potential to significantly reduce calculation costs by training on neuromorphic hardware. In this paper, a visually inspired computational model composed of an SNN and echo state network (ESN) is proposed for the recognition of optic flow. The visually inspired SNN model serves as a foundation model that is trained using spike-timing-dependent plasticity (STDP) for extracting core features. The ESN model makes readout decisions for recognition tasks using the linear regression method. The results show that STDP can perform similar functions as non-negative matrix decomposition (NMF), i.e., generating sparse and linear superimposed readouts based on basis flow fields. Once the foundation model is fully trained from enough input samples, it can considerably reduce the training samples required for ESN readout learning. Our proposed SNN-based foundation model facilitates efficient and cost-effective task learning and could also be adapted to new stimuli that are not included in the training of the foundation model. Moreover, compared with the NMF algorithm, the foundation model trained using STDP does not need to be retrained during the testing procedure, contributing to a more efficient computational performance.
Topical Fibrin Sealant (Tisseel@) Does Not Provide a Synergic Blood-Conservation Effect with Tranexamic Acid in Total Knee Arthroplasty—A Prospective Randomized Controlled Trial
Authors: Liu Chia-Hung , Chang Chih-Hsiang , Chang Yu-Han , Shih Hsin-Nung , Hu Chih-Chien
Published: November 2023

Background and Objectives: The efficacy of tranexamic acid (TXA) in reducing perioperative blood loss during total knee arthroplasty (TKA) is well established. However, the potential synergistic blood-conservation effect of topical fibrin sealant (Tisseel@) remains unclear. This study aims to assess the effectiveness of the combination of Tisseel and TXA during TKA. Materials and Methods: A single-blinded, prospective, randomized controlled trial was conducted with 100 patients (100 knees) undergoing primary TKA. Participants were randomly assigned to either the TXA group (n = 50), receiving intravenous (IV) TXA, or the Tisseel@ + TXA group (n = 50), receiving intra-articular Tisseel@ combined with IV TXA. The primary outcomes included blood transfusion rate, decrease in Hb level, calculated blood loss, and estimated total postoperative blood loss. Secondary outcomes involved assessing clinical differences between the groups. Results: The transfusion rate was zero in both groups. The average estimated blood loss in the Tisseel@ + TXA group was 0.463 ± 0.2422 L, which was similar to that of the TXA group at 0.455 ± 0.2522 L. The total calculated blood loss in the Tisseel@ + TXA group was 0.259 ± 0.1 L, compared with the TXA group’s 0.268 ± 0.108 L. The mean hemoglobin reduction in the first 24 h postoperatively was 1.57 ± 0.83 g/dL for the Tisseel@ + TXA group and 1.46 ± 0.82 g/dL for the TXA-only group. The reduction in blood loss in the topical Tisseel@ + TXA group was not significantly different from that achieved in the TXA-only group. The clinical results of TKA up to the 6-week follow-up were comparable between the groups. Conclusions: The combination of the topical fibrin sealant Tisseel@ and perioperative IV TXA administration, following the described protocol, demonstrated no significant synergistic blood-conservation effect in patients undergoing TKR.
Effect of Prewarming on Perioperative Hypothermia in Patients Undergoing Loco-Regional or General Anesthesia: A Randomized Clinical Trial
Authors: Recio-Pérez Jesus , Miró Murillo Miguel , Martin Mesa Marta , Silva García Javier , Santonocito Cristina , Sanfilippo Filippo , Asúnsolo Angel
Published: November 2023

Background and Objectives: Redistribution hypothermia occurs during anesthesia despite active intraoperative warming. Prewarming increases the heat absorption by peripheral tissue, reducing the central to peripheral heat gradient. Therefore, the addition of prewarming may offer a greater preservation of intraoperative normothermia as compared to intraoperative warming only. Materials and Methods: A single-center clinical trial of adults scheduled for non-cardiac surgery. Patients were randomized to receive or not a prewarming period (at least 10 min) with convective air devices. Intraoperative temperature management was identical in both groups and performed according to a local protocol. The primary endpoint was the incidence, the magnitude and the duration of hypothermia (according to surgical time) between anesthetic induction and arrival at the recovery room. Secondary outcomes were core temperature on arrival in operating room, surgical site infections, blood losses, transfusions, patient discomfort (i.e., shivering), reintervention and hospital stay. Results: In total, 197 patients were analyzed: 104 in the control group and 93 in the prewarming group. Core temperature during the intra-operative period was similar between groups (p = 0.45). Median prewarming lasted 27 (17–38) min. Regarding hypothermia, we found no differences in incidence (controls: 33.7%, prewarming: 39.8%; p = 0.37), duration (controls: 41.6% (17.8–78.1), prewarming: 45.2% (20.6–71.1); p = 0.83) and magnitude (controls: 0.19 °C · h−1 (0.09–0.54), prewarming: 0.20 °C · h−1 (0.05–0.70); p = 0.91). Preoperative thermal discomfort was more frequent in the prewarming group (15.1% vs. 0%; p < 0.01). The interruption of intraoperative warming was more common in the prewarming group (16.1% vs. 6.7%; p = 0.03), but no differences were seen in other secondary endpoints. Conclusions: A preoperative prewarming period does not reduce the incidence, duration and magnitude of intraoperative hypothermia. These results should be interpreted considering a strict protocol for perioperative temperature management and the low incidence of hypothermia in controls.
Non-Communicable Diseases and Associated Risk Factors in Burning Mouth Syndrome Patients
Authors: Parlatescu Ioanina , Dugan Cosmin , Popescu Bogdan Ovidiu , Tovaru Serban , Dobre Maria , Milanesi Elena
Published: November 2023

Background and Objectives: Noncommunicable diseases (NCDs) are a group of non-transmissible conditions that tend to be of long duration and are the result of a combination of genetic, physiological, environmental, and behavioral factors. Although an association between oral disorders and NCDs has been suggested, the relationship between Burning Mouth Syndrome (BMS) and NCDs and their associated risk factors has not been deeply investigated. In this study, we aim to identify associations between BMS and NCDs in the Romanian population. Materials and Methods: Ninety-nine BMS patients and 88 age-matched controls (aged 50 and over) were clinically evaluated for the presence of eight noncommunicable diseases (NCDs) and their most common risk factors, including hypertension, dyslipidemia, smoking, and obesity. Results: The results of our study showed that the BMS in the Romanian population seems to be significantly associated with cardiovascular diseases (CVDs) (p < 0.001) and two of their risk factors, hypertension (p < 0.001) and dyslipidemia (p < 0.001). Moreover, evaluating the Framingham Risk Score (FRS) in the individuals not affected by CVDs (73 CTRL and 38 BMS), we found that 13.2% of BMS patients reported a moderate risk of developing CVDs in ten years, compared to the controls, all of whom presented a low risk (p = 0.002). Conclusions: Our findings suggest that a multidisciplinary clinical approach, which also includes a cardiovascular evaluation, is essential for the successful management of BMS. Moreover, these data highlighted the importance of introducing an integrated strategy for the prevention and care of NCDs in BMS patients.
The Role of Imaging Investigations in Evaluation of Cochlear Dimensions in Candidates for Cochlear Implantation—Our Experience
Authors: Neagoș Cristian Mircea , Domuța Eugenia Maria , Vlad Anca Gabriela , Neagoș Adriana
Published: November 2023

Background and Objectives: The Cochlear implant is the first approved cranial nerve stimulator that works by directly stimulating the cochlear nerve. Various attempts have been made to evaluate the dimensions of the cochlea related to cochlear implantation. The preoperative computed tomographic examination is essential not only in assessing the anatomical aspect of the cochlea, but also in determining its dimensions to choose an appropriate electrode and obtain the best possible audiological performance. Materials and Methods: In the present paper, we aimed to carry out an observational study regarding the role of cochlear measurements in the preoperative evaluation of patients proposed for cochlear implants. The purpose of the study was to measure the cochlea and establish the existence of a correlation between the size of the cochlea and the age and gender of the patients. Results: From the group of 35 examined patients, 54% (n = 19) were male and 46% (n = 16) were female. The average length of the cochlea in the age group 0–4 years is 7.82 mm in the left ear and 7.86 mm in the right ear; in the age group 4–7 years, it is 7.82 mm and 7.94 mm, respectively; for the age group 7–14 years, the dimensions increase to 8.48 mm and 8.77 mm, respectively; and after 14 years, these dimensions reach 9.12 mm and 9.18 mm, respectively. Comparative measurements of the length of the cochlea by age groups show an increase in length with the patient’s age, but this increase does not exceed 1.5 mm for both the right and left ears. The measurements of the width of the cochlea, by age group, start from 6.84 mm in the left ear and 6.81 mm in the right ear at 0–4 years, 6.94 mm and 6.97 mm, respectively, in the group 4–7 years, 7.71 mm and 7.55 mm at 7–14 years, and reaching 8.19 mm and 8.12 mm at the age of 14 years and over. Conclusions: From the study carried out, it can be concluded that the evaluation of the dimensions of the cochlea is important for cochlear implantation. The size variables, although small, are still an element to be considered in correlation with the age of the patient and the implanted ear. This increase is statistically insignificant, but it still exists, even if, from a theoretical point of view, it is considered that the dimensions of the cochlea remain constant.
Heterogeneous Anion-Exchange Membranes with Enhanced Ion Conductivity for Continuous Electrodeionization
Authors: Lee Ji-Min , Kang Moon-Sung
Published: November 2023

In this study, the optimal fabrication parameters of a heterogeneous anion-exchange membrane (AEM) using an ionomer binder are investigated to improve the performance of continuous electrodeionization (CEDI) for producing ultrapure water. Poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) is selected as the base material for preparing the ionomer binder and quaternized to have various ion exchange capacities (IECs). The optimal content of ion-exchange resin (IER) powder according to the IEC of the ionomer binder is then determined through systematic analyses. In conclusion, it is revealed that a heterogeneous AEM with optimal performance can be fabricated when the IEC of the ionomer binder is lowered and the content of IER powder is also lower than that of conventional heterogeneous membranes. Moreover, crosslinked quaternized PPO (QPPO) nanofiber powder is used as an additive to improve ion conductivity without deteriorating the mechanical properties of the membrane. The membrane fabricated under optimal conditions exhibits significantly lower electrical resistance (4.6 Ω cm2) despite a low IER content (30 wt%) compared to the commercial membrane (IONAC MA-3475, 13.6 Ω cm2) while also demonstrating moderate tensile strength (9.7 MPa) and a high transport number (ca. 0.97). Furthermore, it is proven that the prepared membrane exhibits a superior ion removal rate (99.86%) and lower energy consumption (0.35 kWh) compared to the commercial membrane (99.76% and 0.4 kWh, respectively) in CEDI experiments.
Study of Adaptation Processes in Tribofilms during Friction of Antifriction Aluminum Alloys for Journal Bearings
Authors: Podrabinnik Pavel , Gershman Iosif , Mironov Alexander , Kuznetsova Ekaterina , Okunkova Anna A. , Grigoriev Sergey N.
Published: November 2023

This paper provides results on the tribological behavior of experimental Al–Sn–Pb–Si–Cu–Mg–Zn aluminum alloys and describes the adaptation phenomena that reduce wear intensity during friction with steel. The main focus is on tribofilm formation, which plays an important role in friction energy dissipation. The alloys were tested in a rig imitating a journal-bearing shaft couple, and the friction surfaces were studied by the scanning electron microscopy, energy-dispersive analysis and X-ray photoelectron spectroscopytechniques. Based on the analysis, a conclusion on processes and tribochemical reactions was made. Compared to the initial state, eight new compounds were found on the friction surface. In the most wear-resistant alloy, magnesium precipitated from a solid solution with the subsequent oxidation. The same process was detected for zinc in the least wear-resistant alloy due to its low magnesium content. Furthermore, CuSn3 and PbS compounds, which require >600 °C temperature to compose, were found in tribofilms, indicating that the rubbing body lost thermodynamic equilibrium during friction. The revealed processes are non-spontaneous and decrease the wear intensity of the alloys, as they are accompanied by negative entropy production and dissipation of friction energy. Stepwise depth XPS analysis also showed the functional levels of the tribofilms.
Hybrid Smoothed-Particle Hydrodynamics/Finite Element Method Simulation of Water Droplet Erosion on Ductile Metallic Targets
Authors: Mora Alejandro , Xu Ruihan , Schmauder Siegfried
Published: November 2023

Erosion of metallic surfaces due to the permanent impact of high-speed water droplets is a significant concern in diverse industrial applications like turbine blades, among others. In the initial stage of water droplet erosion, there is an incubation regime with negligible mass loss whose duration is strongly dependent on water droplet sizes and velocities, the initial state of the surface, and the material properties of the target. The prediction of the incubation period duration is one of the main topics of research in the field. In this work, the interaction of the water droplets with a metallic surface is simulated using a hybrid Smoothed-Particle Hydrodynamics/Finite Element Method modeling scheme. The effect of multiple random impacts on representative target areas for certain ranges of impact angles and velocities was studied using a combination of simple material and damage models for the target surface of Ti-6Al-4V titanium alloy. The simulation is able to reproduce the main dependencies of the incubation regime and the first stages of water droplet erosion on the impact angle and velocity as reported in the literature. This framework can be considered a foundation for more advanced models with the goal of a better understanding of the physical mechanisms behind the incubation regime in order to devise strategies to extend it in real applications.