bluuebunny/crossref_metadata_2025 huggingface dataset:
Imatinib: A Perspective on Its Potential for PAH Patients
Authors: White R. James , Gomberg-Maitland Mardi , Feldman Jeremy , Preston Ioana , Mathai Steve
Published: May 2019

We invited 4 experts to a telephone roundtable facilitated by guest editor Jim White, MD, PhD, on April 13, 2012, to discuss the results of the recent Phase III trial, the Imatinib in Pulmonary Arterial Hypertension (IMPRES) trial (NCT00902174). Investigators enrolled patients with pulmonary arterial hypertension with severe hemodynamic impairment at catheterization despite treatment with 2 background therapies. Patients were randomized to placebo or 200 mg imatinib twice daily for 6 months of therapy to assess efficacy. Participating in the discussion were Mardi Gomberg-Maitland, MD, MSc, Associate Professor of Medicine and Director, Pulmonary Hypertension Center, University of Chicago; Iona Preston, MD, Co-director, Pulmonary Hypertension Center, Tufts University Medical Center, Boston; Jeremy Feldman, MD, Director, Pulmonary Hypertension Program, Medical Director of Research, Arizona Pulmonary Specialists, Phoenix; Stephen Mathai, MD, MHS, Assistant Professor of Medicine, The Johns Hopkins School of Medicine, Baltimore.
Pulmonary Hypertension Roundtable
Authors: Channick Richard , Farber Hap , Hill Nicholas , Schilz Robert
Published: May 2019

This discussion was moderated by Richard Channick, MD, Associate Professor of Medicine, Pulmonary and Critical Care Division, University of California, San Diego Medical Center, San Diego, California. The physicians participating included Hap Farber, MD, Director, Pulmonary Hypertension Center, Boston University Medical Center, Boston, Massachusetts; Nicholas Hill, MD, Chief, Pulmonary, Critical Care and Sleep Division, Tufts-New England Medical Center, Boston, Massachusetts; and Robert Schilz, PhD, DO, Director of Lung Transplantation and Advanced Lung Disease, and Assistant Professor of Medicine, Case Western Reserve University, Cleveland, Ohio.
• Identifying the Complex Spectrum of Childhood PAH• Selecting Candidates for Aggressive Treatment
Authors: Rosenzweig Erika Berman , Abman Steven H. , Ivy Dunbar , Haworth Sheila G.
Published: May 2019

This discussion was moderated by Erika Berman Rosenzweig, MD, Assistant Professor of Pediatrics (in Medicine), Columbia University College of Physicians and Surgeons, New York, New York. Panel members included Steven H. Abman, MD, Professor of Pediatrics and Director of the Pediatric Heart-Lung Center at The Children’s Hospital, University of Colorado School of Medicine, Denver, Colorado; Dunbar Ivy, MD, Associate Professor of Pediatrics, University of Colorado Health Sciences Center, The Children’s Hospital, Chief of Pediatric Cardiology, and Director of the Pulmonary Hypertension Program, University of Colorado Health Sciences Center, Denver, Colorado; and Sheila G. Haworth, MD, FRCP, Professor of Developmental Cardiology, Institute of Child Health, University College, London, UK, and Lead Clinician at the United Kingdom Pulmonary Hypertension Service for Children.
• Recapping Highlights from the 2006 PHA Scientific Sessions• Reviewing New Perspectives on Inflammation, Genetics, and Imaging• Redefining Exercise-Induced PH• Future Considerations in Translational Research
Authors: Fagan Karen A. , Badesch David B. , Elliott C. Gregory , Frantz Robert P.
Published: May 2019

This discussion was moderated by Karen A. Fagan, MD, Associate Professor of Medicine, University of Colorado Health Sciences Center, Denver, Colorado. Panel members included David B. Badesch, MD, Professor of Medicine, Divisions of Pulmonary Sciences & Critical Care Medicine, and Cardiology Clinical Director, Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colorado; C. Gregory Elliott, MD, Professor of Medicine, University of Utah School of Medicine, Pulmonary Division, LDS Hospital, Salt Lake City, Utah; and Robert P. Frantz, MD, Assistant Professor of Medicine, Mayo Clinic College of Medicine, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Evaluating Operability in Adults with Congenital Heart Disease and the Role of Pretreatment with Targeted Pulmonary Arterial Hypertension Therapy
Authors: Dimopoulos Konstantinos , Gatzoulis Michael A.
Published: May 2019

Despite recent advances in cardiac surgery that have allowed repair of congenital heart defects at a very young age, pulmonary arterial hypertension (PAH) secondary to congenital heart disease (CHD) remains a major problem. In its most severe form, the Eisenmenger syndrome, PAH and its complications result in a significant increase in morbidity and mortality and also greatly affect the quality of life of patients.
National Heart Lung and Blood Institute Hopkins Specialized Center in Clinical Oriented Research (SCCOR): Molecular Determinants of Pulmonary Arterial Hypertension
Authors: Hassoun Paul M.
Published: May 2019

SCCOR Investigators: Paul M. Hassoun: overall Principal Investigator, Project 1 leader and administrative core leader; Hunter C. Champion: Project 2 leader; Fredrick Wigley: Project 3 leader; Roger A. Johns: Project 4 leader; Michael Crow: Project 5 leader; Noah Lechtzin: data management and statistics; Allen Myers: pathology core; Kathleen C. Barnes: genetics/genomics core; Jennifer van Eyk: proteomics core; and Jens Vogel-Claussen: imaging core.
Specialized Center in Clinical Oriented Research (SCCOR) Update: Mechanisms and Treatment of Lung Vascular Disease in Infants and Children
Authors: Stenmark Kurt
Published: May 2019

SCCOR Investigators: John Kinsella: Principal Investigator (PI) Project 1; Robin Shandas, PI, Dunbar Ivy, Co-PI: Project 2; Kurt Stenmark. PI: Project 3; Carl White, PI: Project 4.
Exercise Training and Pulmonary Rehabilitation in the Pulmonary Hypertension Patient
Authors: Bartolome Sonja D.
Published: May 2019

Recent evidence challenges the traditional wisdom regarding the risks of exercise in PAH patients. Clearly, there are some patients who benefit from the addition of pulmonary rehabilitation to their medical treatment. Still, the details regarding the optimal patient population, timing, and makeup of the program are undefined. As evidence mounts regarding the safety and benefits of an exercise regime in patients with PAH, pulmonary rehabilitation may become another tool to improve the quality of life for these patients.
Conference Abstracts
Authors: Chun Hyung
Published: May 2019

A total of 69 abstracts were presented during the poster sessions at the Conference. The winning abstracts in Basic Science and Clinical Science were presented as oral abstracts during the scientific sessions and are included in this issue of Advances.
Of Ethics, Trials, and Tribulations
Authors: Aldrighetti Rino , Bodin Frederic , Halpern Scott , Farber Harrison W.
Published: May 2019

Experts representing different parts of the team involved in clinical trials came together on a call to discuss the current state of conducting clinical trials in PAH. Below is the account of the invigorating conversation moderated by guest editor Harrison Farber, MD, from Boston University, with Frederic Bodin, MD, VP, Head, Global Medical Science and Communication, Actelion; Scott Halpern, MD, PhD, MBE, University of Pennsylvania, and Rino Aldrighetti, President, Pulmonary Hypertension Association.
Advances in Predicting Subcellular Localization of Multi-label Proteins and its Implication for Developing Multi-target Drugs
Authors: Chou Kuo-Chen
Published: May 2019

The smallest unit of life is a cell, which contains numerous protein molecules. Most of the functions critical to the cell’s survival are performed by these proteins located in its different organelles, usually called ‘‘subcellular locations”. Information of subcellular localization for a protein can provide useful clues about its function. To reveal the intricate pathways at the cellular level, knowledge of the subcellular localization of proteins in a cell is prerequisite. Therefore, one of the fundamental goals in molecular cell biology and proteomics is to determine the subcellular locations of proteins in an entire cell. It is also indispensable for prioritizing and selecting the right targets for drug development. Unfortunately, it is both timeconsuming and costly to determine the subcellular locations of proteins purely based on experiments. With the avalanche of protein sequences generated in the post-genomic age, it is highly desired to develop computational methods for rapidly and effectively identifying the subcellular locations of uncharacterized proteins based on their sequences information alone. Actually, considerable progresses have been achieved in this regard. This review is focused on those methods, which have the capacity to deal with multi-label proteins that may simultaneously exist in two or more subcellular location sites. Protein molecules with this kind of characteristic are vitally important for finding multi-target drugs, a current hot trend in drug development. Focused in this review are also those methods that have use-friendly web-servers established so that the majority of experimental scientists can use them to get the desired results without the need to go through the detailed mathematics involved.
3D Printing Technology: A New Milestone in the Development of Pharmaceuticals
Authors: Chandekar Anish , Mishra Dinesh K. , Sharma Sanjay , Saraogi Gaurav K. , Gupta Umesh , Gupta Gaurav
Published: May 2019

The global market of pharmaceuticals has witnessed a new revolution recently in the form of threedimensional printing (3D) technology. 3D printing has its existence since the 1980s that uses a 3D printer to manufacture the different dosage forms through computer-aided drug design technology. The need for 3D printing is due to numerous advantages like personalized medicine, tailored doses, rapid disintegration in case of SLS technique, incorporation of high doses and taste masking capacity. The different techniques used in 3D printing are Powder based (PB), Semi-solid extrusion (EXT), Fused deposition modeling (FDM), Stereolithographic (SLA) and Selective laser sintering (SLS) 3D printing. However, from the latest reports of association of pharmaceutical 3D printing technology, it is evidenced that this technology is still in its infancy and its potential is yet to be fully explored. The present review includes sections for introduction and scope of 3D printing, personalized medicines and their approaches, historical aspects, research milestones, and various 3D printing techniques.
Connected Speech Deficit as an Early Hallmark of CSF-defined Alzheimer’s Disease and Correlation with Cerebral Hypoperfusion Pattern
Authors: Mazzon Giulia , Ajčević Miloš , Cattaruzza Tatiana , Menichelli Alina , Guerriero Michele , Capitanio Selene , Pesavento Valentina , Dore Franca , Sorbi Sandro , Manganotti Paolo , Marini Andrea
Published: May 2019

Background:

Diagnosis of prodromal Alzheimer's disease (AD) still represents a hot topic and
there is a growing interest for the detection of early and non-invasive biomarkers. Although progressive
episodic memory impairment is the typical predominant feature of AD, communicative difficulties can be
already present at the early stages of the disease.

Objective:

This study investigated the narrative discourse production deficit as a hallmark of CSFdefined
prodromal AD and its correlation with cerebral hypoperfusion pattern.

Method:

Narrative assessment with a multilevel procedure for discourse analysis was conducted on 28
subjects with Mild Cognitive Impairment (15 MCI due to AD; 13 MCI non-AD) and 28 healthy controls.
The diagnostic workup included CSF AD biomarkers. Cerebral hypoperfusion pattern was identified by
SPECT image processing.

Results:

The results showed that the discourse analysis of global coherence and lexical informativeness
indexes allowed to identify MCI due to AD from MCI non-AD and healthy subjects. These findings allow
to hypothesize that the loss of narrative efficacy could be a possible early clinical hallmark of Alzheimer’s
disease. Furthermore, a significant correlation of global coherence and lexical informativeness
reduction with the SPECT hypoperfusion was found in the dorsal aspect of the anterior part of the left
inferior frontal gyrus, supporting the hypothesis that this area has a significant role in communicative
efficacy, and in particular, in semantic selection executive control.

Conclusion:

This study contributes to the understanding of the neural networks for language processing
and their involvement in prodromal Alzheimer's disease. It also suggests an easy and sensitive tool for
clinical practice that can help identifying individuals with prodromal Alzheimer’s disease.
Plasma Membrane Proteomic Profile Discovers Macrophage-capping Protein Related to Latent HIV-1
Authors: Zhang Yujiao , Shen Yinzhong , Yin Lin , Qi Tangkai , Jia Xiaofang , Lu Hongzhou , Zhang Lijun
Published: May 2019

Background:

Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely.

Objective:

To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines.

Method:

An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 cells, A7 cells) and its parental cell line (Jurkat cells) were used. The plasma membrane (PM) fraction from cultured cells was enriched through aqueous two-phase partition. PM proteins were extracted and then separated using two-dimensional electrophoresis (2DE). Differentially expressed proteins were identified by mass spectrometry, and verified by western blotting.

Results:

Thirteen non-redundant proteins were identified to be differentially expressed in the A7 PM fraction compared to those in the Jurkat PM. Eight had a PM location through Gene Ontology (GO) analysis. A differential protein network of CAPG-ACTR3-CD3D was detected to have interactions with HIV Vpr, Tat, gp160, etc. through STRING software analysis. One of the differential proteins (Macrophage-capping protein (CAPG)) was verified by western blotting to be down- regulated in two cell lines and HIV resting CD4+ T cells negatively selected from patients.

Conclusion:

We identified 13 proteins in A7 compared to Jurkat cells. CAPG may be a potential biomarker related to HIV latency.
Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
Authors: Maslov Leonid N. , Tsibulnikov Sergey Y. , Prokudina Ekaterina S. , Popov Sergey V. , Boshchenko Alla A. , Singh Nirmal , Zhang Yi , Oeltgen Peter R.
Published: May 2019

The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.
In Vitro Evaluation of Chitosan Induced Cytotoxicity against Cancerous Cell lines: MCF-7, Saos-2 and HeLa
Authors: Abedian Zeinab , Jenabian Niloofar , Moghadamnia Ali Akbar , Zabihi Ebrahim , Pourbagher Roghayeh , Ghasemi Masoumeh , Nouri Hamid Reza
Published: May 2019

Objective/ Background:

Cancer is still the most common cause of morbidity in world and new powerful anticancer agents without severe side effects from natural sources is important.

Methods:

The evaluation of cytotoxicity and apoptosis induction was carried out in MCF-7,HeLa and Saos-2 as cancerous cell lines with different histological origin and human fibroblast served as control normal cell. The cells were treated with different concentrations of chitosan and the cytotoxicity was determined using MTT assay after 24, 48 and 72 h .The mode of death was evaluated by flow cytometry .

Results:

While both types of chitosan showed significant concentration-dependently cytotoxic effects against the three cancerous cell lines, fibroblast cells showed somehow more compatibility with chitosan. On the other hand, there were no significant differences between LMWC and HMWC cytotoxicity in all cell lines. The flow cytometry results showed the apoptosis pattern of death more in Saos-2 and HeLa while necrosis was more observable with MCF7. Also higher viability with both types of chitosan was seen in fibroblast as normal cells

Conclusion:

Chitosan shows anticancerous effect against 3 cancerous cell lines, while it is compatible with normal diploid fibroblast cells. Furthermore, it seems that the molecular weight of chitosan does not affect its anticancerous property.
Hemodynamic Changes of Hepatic & Renal Vessels in Systemic Bacterial Infection with Fever in HCV Related Cirrhosis
Authors: Helal Eman Mohammed , Sharaf-Eldin Mohamed , Abou El Azm Abdel Raouf , Badr Eldin Nagwa Mansour , Dawoud Mohammed Mahmoud , Abd-Elsalam Sherief , Ziada Dina Hazem
Published: May 2019

Objective:

To study the hemodynamic changes of hepatic & renal vessels in systemic
bacterial infection with fever in HCV related cirrhosis with possible complications.

Methods:

Three groups of patients with systemic bacterial infection with fever were included in
the study; group І included 15 patients with decompensated cirrhosis, group ІІ included 15 patients
with compensated cirrhosis and group ІІІ included 10 patients without liver affection. Laboratory
parameters and Doppler US of hepatic and renal vessels were evaluated during and after
subsidence of fever in all patients.

Results:

Forty patients were enrolled in this prospective study. There were 22 male and 18 female
patients. We found that the direction of blood flow in the portal and splenic veins was hepatopetal
and the veins were non pulsatile in all cases with no change during and after subsidence of infection.
There was no significant difference in portal or splenic vein diameters during and after subsidence
of infection in the three studied groups. However, the mean values of portal and splenic
veins peak velocities were significantly lower during infection in cirrhotic groups. The mean value
of hepatic artery resistive index during fever was significantly higher than after fever in cirrhotic
groups. Renal resistive and pulsatility indices were significantly higher during fever in cirrhotic
groups.

Conclusion:

Systemic bacterial infection with fever can affect hepatic haemodynamics leading to
aggravation of portal hypertension and increasing the risk of complications as variceal bleeding
and hepatic encephalopathy and can also affect renal haemodynamics with increased risk of renal
impairment.
APPLICATION OF SUPERCOMPUTER TECHNOLOGIES FOR REASONABLE CHOICE OF RATIONAL ANTIMISSILE DEFENSE GROUP
Authors: Kuzovov K. D. , Konovalchik A. P. , Bezginov A. N. , Protasov S. A.
Published: May 2019

Reasonable choice of rational antimissile defense group problem is considered. Suboptimal solution of the problem by consecutive solution of several particular optimization problems through simulation modeling of hostilities with variation of several defense group parameters values is proposed. The necessity of supercomputer technologies application to solve the problem is substantiated. A scheme for solving such particular optimization problems is proposed. The implementation of the software for solving the problem on the supercomputer is considered. On the preliminary results on test launches is generally shown that the developed software allows performing the solving of particular optimization problems, in particular, choosing of rational order of the defense group components interaction organization. The conclusion is given that application of supercomputer technologies for reasonable choice of rational antimissile defense group is possible.
UNMANNED AERIAL VEHICLE DETECTION AND JAMMING RADIO COMPLEX
Authors: Ksendzuk A. V.
Published: May 2019

Modern threats for anti-missile system and space surveillance and tracking system objects include terroristic and unidentifiable unmanned aerial vehicle. To counter these threats a concept of radar complex for unmanned aerial vehicles jamming and detection proposed. Complex consists of non-radiating radio locator, radio warfare station and global navigation jamming radar. Structure, principle of operation and basic technical characteristics of these systems described. Counter-drone actions algorithm in proposed complex described and analyzed. Results of mom-radiating radar development in JSC MAK Vimpel and its experimental investigation described. Precision of estimation range, velocity and angular location described. Jamming effectiveness estimator schematic diagram proposed. Jamming effectiveness may be estimated on navigation equipment or program models of prospective GPS receivers. Results of effective jamming signal development presented. Results may be used in small low-energy counter drone radioelectronic systems development for anti-missile and Space Surveillance and Tracking system objects.
ESTIMATION OF SHAPE PARAMETERS OF SPACE OBJECTS WITH USE OF WIDEBAND RADAR SIGNALS
Authors: Lagutkin V. N.
Published: May 2019

Theoretical questions of parametric descriptions of received broadband radar signals, in particular, signals with linear frequency modulation, and their processing for evaluation of form parameters of tracked space objects are considered. Analytical expressions for the received broadband radar signal at the output of the antenna system and its spectrum are obtained. Received expression take into account the spectral characteristics of polarization matrix of radio waves backscattering from space objects, as well as movement parameters of monitored objects. Address issues of physical diffraction theory methods for calculating spectral characteristics of radio waves backscattering from space objects. At considering of processing of received broadband signals from objects they are represented as the sum of component from individual «shining spots», then parameters of objects form are number of «shining spots», delays and complex amplitudes of their signals. It is shown that sufficient statistics at processing of received broadband signals to evaluate form parameters of space objects is the Fourier transform of product of complex conjugate of complex spectrum of envelope received signal and spectrum of complex envelope of sounding signal, modified in view of object movement. On the basis of computations of delay response functions for axisymmetric objects with circular kinked surfaces and sounding signals with linear frequency modulation the features of the task of evaluating the form parameters of space objects are shown and general requirements for parameters of sounding signals, for energy and a range of angles of observation are formulated.
THE EFFECT OF EARTH SURFACE MAP DISCRETENESS ON THE ACCURACY OF THE ECHO SIGNALS SIMULATION
Authors: Oreshkina M. V. , Kiselev A. V.
Published: May 2019

It is the most expedient way to use digital terrain maps as the earth surface model for radar echo signal simulation. In this case, the discrete nature of digital maps leads to the appearance of particular errors in calculating the parameters of simulated signals. The objective of this work is to determine the error dependence of the sampling interval on the map. The general relations connecting errors for calculating the power of the echo signals and their correlation functions with the correlation function of the random field describing the distribution of the surface reflecting properties are obtained. The expressions that connect the error values with the sampling interval for the Markov random field are obtained on their basis. These expressions are specified for the most common reconstruction filters. The requirements for the sampling interval for achieving the adjusted error level are defined.
EVALUATION AND COMPENSATION OF SYSTEMATIC ERRORS OF CALIBRATION OF MATRIX SIMULATOR
Authors: Kiselev A. V. , Podkopaev A. O. , Stepanov M. A.
Published: May 2019

The problem of phase calibration of the matrix simulator is considered. The phase error at the point of reception is divided into systematic and random. Analytic relationships are obtained that allow one to evaluate and compensate for the systematic error in the calibration of the phases of the signals emitted by the matrix simulator, caused by the geometric separation of the phase centers of the antenna and the antenna of the calibration receiver. The random component of the phase error is compensated by the calibration algorithm. Analytical relations are obtained for determining the compensation error due to the non-precise determination of the coordinates of the emitting part of the matrix simulator and the phase center of the antenna of the measuring receiver. The magnitude of this error is determined for the typical location of the antennas of the device under investigation, the measuring receiver and the matrix simulator when performing semi-realistic simulation. The description of the laboratory stand of the developer of the matrix imitator is given. The obtained theoretical results are confirmed experimentally at the booth of the matrix imitator developer.
SYNTHESIS OF BROADBAND DISTRIBUTED IMPEDANCE TRANSFORMERS WITH A GIVEN PHASE RESPONSE
Authors: Volkhin D. I. , Devyatkov G. N.
Published: May 2019

The development of a new class of broadband matching devices, including active impedance transformers, with the possibility of correcting the phase response is an actual task at present. Synthesis of a broadband active impedance transformer with a phase response corresponding to a second-order lattice X-section in a distributed elemental basis based on the previously presented method for the synthesis of broadband matching devices with predetermined phase response is considered in this paper. As a result of synthesis, the y-matrix of the broadband transforming two-port network is obtained. The functions of its own parameters represented in the form of Foster. Applying various conditions of circuit realizability in the synthesis process, we obtained structures convenient for realization on microwave on regular transmission lines, one of which is investigated at various parameters of a given phase response. As a result of the research, it is found that the structure has a wide ability to reproduce the phase response of a second-order lattice X-section with different parameters, and also reproduce the linear phase response characteristic while maintaining an acceptable level of the power conversion coefficient in a given frequency band. Thus, the efficiency of the previously proposed method of synthesis of broadband matching devices with predetermined phase response is demonstrated, and also the possibilities of active impedance transformers on regular transmission lines are shown.
THE POWER DIVIDER-COMBINER WITH ADDITIONAL CAPACITIVE CORRECTION AT THE INPUT OF THE DEVICE
Authors: Govorukhin V. I. , Unru N. E.
Published: May 2019

A sinphase divider-combiner of Wilkinson's power is widely used in practice. However, by the manufacturing of high power dividers, the parasitic capacitance of the ballast resistors begins to affect. The authors proposed an option for additional capacitive correction of parasitic capacitances of ballast resistors, which allows to significantly improve the technical characteristics of the device. A Analytic expressions for the calculating the value of the correcting capacitance are proposed. The quality of the proposed correction method is confirmed by the results of computer modeling.
THE WAYS TO IMPROVE RELIABILITY OF POWER SUPPLY CIRCUITS OF GROUND STATIONARY OBJECTS ELECTRONIC EQUIPMENT
Authors: Libenko Yu. N. , Parfenov A. V.
Published: May 2019

Modern radio electronic equipment (REE) in various areas of economic activity performs increasingly complex tasks at sites with increased levels of responsibility. This circumstance increases the dependence of the operation of the REE on the uninterrupted power supply and its quality level, as well as on the level of fault tolerance of an important auxiliary part of the REE - power supply system (PSS), which significantly affects the ability of the REE to perform its tasks. The results of the analysis of existing and search for promising ways to ensure a given level of reliability of REE associated with its power supply problems show the need for an integrated approach to choosing the most effective option. It consists in the cumulative implementation of the process indicated by the newly introduced term «reliability of the power supply chain (PSC) of the REE», combining the continuity of supplying REE with electricity of the established level of quality and trouble-free operation of the PSS performing the conversion of the initial electricity to the form and the values of its parameters acceptable for the power supply of the functional units REE. Ways to improve the reliability of the PSC of the REE of ground stationary objects are considered for two of its characteristic types - a computer system (CS) and a telecommunication system (TS) with a single-phase voltage of 220V; 50Hz and the value of power consumption to 3-5kW. In terms of increasing the continuity of electricity supply, the feature of the proposed solutions is the achievement of the set goal by additional use of existing resources of the facilities of the REE installation. In some cases, their limited increase is also envisaged. In order to increase the fault tolerance, the PSS REA suggests: in the centralized part of the PSS - the application of the trunk-modular architecture, the choice of the effective structure, and also the adaptive methods and algorithms for management and redundancy, in the distributed part of the PSS - optimization of the structure and minimization of the number of constituent parts.
THE PROBLEM OF PROVIDING CACHE COHERENCE IN MULTIPROCESSOR SYSTEMS WITH MANY PROCESSORS
Authors: Shmeylin B. Z. , Alekseeva E. A.
Published: May 2019

In this paper the tasks of managing the directory in coherence maintenance systems in multiprocessor systems with a large number of processors are solved. In microprocessor systems with a large number of processors (MSLP) the problem of maintaining the coherence of processor caches is significantly complicated. This is due to increased traffic on the memory buses and increased complexity of interprocessor communications. This problem is solved in various ways. In this paper, we propose the use of Bloom filters used to accelerate the determination of an element’s belonging to a certain array. In this article, such filters are used to establish the fact that the processor belongs to some subset of the processors and determine if the processor has a cache line in the set. In the paper, the processes of writing and reading information in the data shared between processors are discussed in detail, as well as the process of data replacement from private caches. The article also shows how the addresses of cache lines and processor numbers are removed from the Bloom filters. The system proposed in this paper allows significantly speeding up the implementation of operations to maintain cache coherence in the MSLP as compared to conventional systems. In terms of performance and additional hardware and software costs, the proposed system is not inferior to the most efficient of similar systems, but on some applications and significantly exceeds them.
MODEL OF INCREASE OF A CLOUDY CALCULATIONS EFFICIENCY DUE TO USE OF DYNAMIC PROGRAMM LIBRARIES AND APPLIED FUNCTIONAL SERVICES
Authors: Balashov V. M. , Morozov S. A. , Gulevitskiy A. Yu.
Published: May 2019

There are considered the matters of state and municipal bodies activity efficiency increase due to modernization of soft-hardware systems for data storage and processing centers. The necessity of creation of maintenance services dynamically connected in the interests of various groups of users is marked out. There are considered the typical hierarchic structures and perspective topologies of soft-hardware complexes network communication that provides services support and accessibility. The twolevel model of network service formation on the basis of programming functions library or other programmed components in the network of soft-hardware systems for data storage and processing centers is considered. As a distinctive feature of the proposed approach to development and support of functions and program components libraries is creation of the UML language based software product visual models having a high semantic saturation. Such approach increases the degree of development information filling, allows decrease a quantity of paper documents.
NEW GENERATION OF ADAPTABLE MOBILE MEANS OF ORGANISATIONAL REPAIR
Authors: Krivolapov V. L. , Strakhov A. F.
Published: May 2019

One of the key factors of ensuring the required level of the AD WME technical readiness for the intended use is minimisation of the time period necessary for restoration of the AD WME systems after their failures. Over the years, JSC Principle Production and Technical Company Granit has per-formed a cycle of R&D activities aimed at creating effective means of the AD WME maintenance and organisational repair at their deployment sites as well as at developing innovative maintenance and organisational repair technologies. Following the results of these activities, a set of adaptable unified mobile repair and diagnostic equipment (RDE)was created and then exported in order to ensure the maintenance and organisational repair of the AD WME pieces delivered within military technical cooperation with foreign countries. Further development of this focus area resulted in creation of a set of unified mobile organisational repair systems. This article considers main functional and technical as well as technological opportunities of the unified mobile organisational repair systems. Their prototypes are previously developed RDE for export.
MODEL FOR ASSESSMENT OF DECISION SUPPORT APPLICATION EFFICIENCY IN RADIO-ELECTRONIC EQUIPMENT MAINTENANCE PROCESSES
Authors: Tikhonov V. B.
Published: May 2019

Modern radio-electronic systems (RES) of weapons and military equipment (WME) are more functionally and structurally sophisticated that results in high requirements for their effective operation organisation. Insufficient level of technical knowledge among RES WME operational and maintenance personnel often results in increase of operability restoration period of these items in case of failures. This, in its turn, results in decrease of the readiness level of the RES WME pieces. In order to reduce duration of the RES WME restoring repair in case of failures, methods and tools of the auto-mated informational support of the operational and maintenance personnel activities related to the WME operation and restoring repair are developed. This article is devoted to development of a model of the automated informational support of the personnel activities in order to find rational options of the RES WME maintenance and repair organisation. The study results related to feasibility evaluation and development of the automated technical operation system model for the radio-electronic equipment incorporated in the AD WME are provided.
EXPERIENCE IN TARGETED TRAINING OF ENGINEERS
Authors: Strakhov O. A. , Strakhov A. F.
Published: May 2019

Currently, a significant part of engineers at the industrial enterprises are persons of preretirement or retirement age. There is a critical need for a young generation of engineers in order to replenish natural loss and ensure new demands for personnel when expending production. A conventional approach to solving this problem is replenishment of engineers by involving university graduates. However, in most cases this approach turns to be inefficient due to several reasons. The first reason is the quality of graduates training. The second reason is lack of practical skills among the university graduates in order to directly involve them in work given the specificity of the enterprise. In particular, it becomes obvious when involving the university graduates in R&D activities. In the Soviet period, there was interesting experience of combining study at a university and involvement in performance of real production tasks by means of organization of «plants-vocational technical institutes» [1, 2]. This article considers the results of an experiment on combining study at universities (according to a flexible schedule) and direct involvement in current R&D activities performed at JSC Principle Production and Technical Company Granit. Besides, the university graduates having major specialisation were involved in a real work from the first course and received fair wage. During three years, the enterprise replenished vacant technical positions by involving students, and when they graduates from the university it receives qualified engineers who have a required set of knowledge and skills in the area of R&D of the enterprise.
NAVIGATION SHARING PROSPECTS GLONASS AND PSEUDOLITES FIELDS FOR NAVIGATION AND LANDING OF AIRCRAFT IN ARCTIC
Authors: Baburov V. I. , Vasileva N. V. , Ivantsevich N. V.
Published: May 2019

In view of the development of the Arctic Region the problem of aircraft (AC) navigation support under arctic conditions throughout the flight, including the landing stage, acquires special momentum. Given that land-based navigation systems have a limited range which does not cover the Arctic Region and are significantly inferior to satellite radio navigation systems (SRNS), SRNS user navigation equipment (UNE) becomes extremely important for AC navigation and landing. The functioning of SRNS UNE in the polar regions is determined by the characteristics of the satellite signal propagation path under arctic conditions and considerable radio signal reflection from the underlying surface. Multipath errors are of special significance for low satellite elevations. If low satellites are excluded from processing by UNE while maintaining acceptable positioning accuracy, both the integral accuracy rates and accessibility may be improved. The paper analyses the composition and information characteristics of working satellite constellations in integrated GLONASS and pseudolites positioning in the Arctic region of Russia. Our study performed by simulation modelling has established considerable redundancy of working constellations at the nominal value of admissible satellite elevation. This factor has been studied for forming controllable working constellations in aircraft on board navigation and landing complex.
FEATURES OF THE WIRELESS ENERGY TRANSFER’S CHANNEL IN A DYNAMIC MODE
Authors: Kochin L. B. , Strakhov S. Yu. , Matveev S. A.
Published: May 2019

Work is devoted to wireless energy transfer to the removed devices by means of laser radiation. This problem is actual in some practical applications. The dynamic mode of the laser wireless energy transfer's channel is considered. The mathematical model is offered. Influence of terminal loading on dynamic processes in the channel is investigated. The factors increased of energy transfer channel's efficiency are analyzed. Parameters of lenses and beam expanders, accuracy of optical component's installation, uniformity of a photocell's light spot are investigated. It is shown, that in a pulse mode efficiency of energy channels depends also on an impedance of loading. Additional impedance increased of fluctuation's amplitude and reduced channel's efficiency. The description of experimental setup, data of measurements and their analysis are resulted.
APPLICATION OF THE PLL CONTROL AT THE REALIZATION OF A 16-THROUGH ADC
Authors: Magerramov R. V.
Published: May 2019

This article describes the method of converting an analog signal into a digital code using a phase locked loop (PLL) circuit. The functional structure of the voltage-to-digital conversion circuit is considered. The application of the principle of phase-locked loop for controlling the duty cycle of the output signal of a phase detector when the voltage at the positive input of the operational amplifier included in the low-pass filter is investigated. In the modern world, analog-to-digital converters (ADCs) are available in almost every electronic device. The application of different ADC architectures is determined by their parameters and features by circuit and technological implementation. The phase-locked loop with a digital part (16-bit counter, storage register and data transfer interface) allows to obtain a precision analog-to-digital converter, based on a relatively simple circuit design, which has high accuracy and low noise level. Negative feedback of the PLL loop makes it possible to level the error of the passive elements of the low-pass filter (LPF) and the voltage controlled oscillator (VCO). The result of this work is an analysis of the ADC characteristics in the technological basis of 250 nm.
A Pilot Randomized Controlled Trial of a Web-Based Growth Mindset Intervention to Enhance the Effectiveness of a Smartphone App for Smoking Cessation (Preprint)
Authors: Sridharan Vasundhara , Shoda Yuichi , Heffner Jaimee , Bricker Jonathan
Published: May 2019

BACKGROUND

Although smartphone apps have shown promise for smoking cessation, there is a need to enhance their low engagement rates. This study evaluated the application of the growth mindset theory, which has demonstrated the potential to improve persistence in behavior change in other domains, as a means to improve engagement and cessation.

OBJECTIVE

This study aimed to explore the feasibility, utility, and efficacy of a Web-based growth mindset intervention for addiction when used alongside a smoking cessation app.

METHODS

Daily smokers (N=398) were all recruited on the Web and randomly assigned to receive either a cessation app alone or the app plus a Web-delivered growth mindset intervention. The primary outcome was engagement, that is, the number of log-ins to the smoking cessation app. The secondary outcome was 30-day point prevalence abstinence at 2-month follow-up collected through a Web-based survey.

RESULTS

The 2-month outcome data retention rate was 91.5% (364/398). In addition, 77.9% (310/398) of the participants in the experimental arm viewed at least 1 page of their growth mindset intervention, and 21.1% (84/398) of the group viewed all the growth mindset intervention. The intention-to-treat analysis did not show statistically significant differences between the experimental and comparison arms on log-ins to the app (19.46 vs 21.61; P=.38). The experimental arm had cessation rates, which trended higher than the comparison arm (17% vs 13%; P=.10). The modified intent-to-treat analysis, including only participants who used their assigned intervention at least once (n=115 in experimental group and n=151 in the control group), showed that the experimental arm had a similar number of log-ins (32.31 vs 28.48; P=.55) but significantly higher cessation rates (21% vs 13%; P=.03) than the comparison arm.

CONCLUSIONS

A growth mindset intervention for addiction did not increase engagement rates, although it may increase cessation rates when used alongside a smartphone app for smoking cessation. Future research is required to refine the intervention and assess efficacy with long-term follow-up to evaluate the efficacy of the mindset intervention.

CLINICALTRIAL

ClinicalTrials.gov NCT03174730; https://clinicaltrials.gov/ct2/show/NCT03174730
IPTEK Bagi Masyarakat (IbM) Melalui Peningkatan Panen Pedet dan Produksi Kompos Berkualitas Pada Kelompok Ternak Sapi Potong
Authors: Atmoko Bayu Andri , Baliarti Endang , Fitriyanto Nanung Agus
Published: May 2019

Beef Cattle have a role as saving for farmers to continue their business, although not profitable based on business analysis. Therefore, the right strategy is needed according to the problems of both the culture and the resources of farmers. The community service activity was conducted in a beef cattle farmer groups as cattle breeding for calf production, namely, are Mergo Andini Makmur and Sumber Ayu in Sleman Regency. The beef cattle productivity in the two groups is not good, S/C is more than twice, even up to four times, postpartum estrus is more than one year, and calving interval is more than 2 years. The beef cattle farmer groups have already diversified their business, which is the processing of manure and waste product of cattle, but not yet optimal. Community service is carried out to improve reproductive performance of cattle through the providing of a superior bull for bull stimulation, counseling, assistance in the prevention of worm infections, and demonstrations of compost and feed quality production. The first stage is preparation, including consolidation with the member farmer groups, followed by the socialization of the activity program. The next stage of implementation, by conducting reproductive and breeding management counseling, cattle health management, feed processing and management, and compost production. The result of the implementation of a bull stimulation for one month is based on the emergence of estrus (more than 50%) following by a conception rate (33.33%) of the cows population, and the level of participatory farmers. The demonstration of the fermented straw feed and compost is also implemented as a supporting activity.
El Bachillerato en Línea del Colegio de Bachilleres: alternativa para abatir el rezago educativo en el Nivel Medio Superior
Authors: BACHILLERES COLEGIO de Bachilleres
Published: May 2019

Desde el 2003, el Colegio de Bachilleres ofrece Educación a Distancia como una alternativa para abatir el rezago de Nivel Medio Superior en México, generando alianzas estratégicas con diversas instituciones públicas y privadas a fin de acercar sus servicios educativos a la población mexicana, dentro y fuera del país, tanto en el aspecto técnico como en espacios físicos.

El Colegio de Bachilleres genera alternativas educativas para ayudar a resolver las necesidades de la población. Desde quienes no pudieron concluir su bachillerato en tiempo, hasta los que, aún dentro del rango de atención de una modalidad escolarizada, prefieren o requieren de una forma de estudio más independiente.

El certificado que el Colegio de Bachilleres emite al concluir el plan de estudios -que contiene entre 46 a 49 asignaturas-, es oficial y reconocido por cualquier instancia de educación superior en México. Su estrategia de trabajo parte del compromiso y claridad en las metas del estudiante, quien siempre cuenta con el apoyo de gestores en la parte técnica y en la solicitud de trámites escolares; así como con la orientación de asesores psicopedagógicos y de contenido. Así, el estudiante se va formando para alcanzar sus metas, a partir del estudio independiente, aprendiendo a organizar, de manera consciente, los recursos académicos que el Colegio pone a su disposición con sus habilidades y circunstancias personales.

A la fecha, el Colegio atiende a 28 entidades federativas en México y a 22 estados de la Unión Americana, ubicándose como una de las instituciones educativas con mayor cobertura. El reto, sin embargo, sigue en pie. Por ello, el Colegio continúa generando condiciones para llegar a más espacios y a un mayor número de mexicanos.
Diez proposiciones para hacer efectivo el e-learning
Authors: Torres Nabel Luis César , Aguayo Alvarez Zeferino
Published: May 2019

En el artículo se exponen diez proposiciones generales que buscan justificada y críticamente el debate sobre líneas generales para desarrollar propuestas efectivas de elearning.

La idea se basa en el texto titulado Ten top tips de Julian Stodd, publicado en la revista e.learning age, en julio de 2008. Al final del texto también se detona el debate teórico que las diez proposiciones implican.