bluuebunny/crossref_metadata_2025 huggingface dataset:
Lactobacillus rhamnosus GG and butyrate supplementation in rats with bone cancer reduces mechanical allodynia and increases expression of μ-opioid receptor in the spinal cord
Authors: Yuan Wenxi , Xiao Jie , Liao Huabao , Xie Zhiyuan , Zhao Yiran , Li Cheng , Zhou Keying , Song Xue-Jun
Published: June 2023

Introduction

Chronic cancer pain is one of the most unbearable symptoms for the patients with advanced cancer. The treatment of cancer pain continues to possess a major challenge. Here, we report that adjusting gut microbiota via probiotics can reduce bone cancer pain (BCP) in rats.

Methods

The model of BCP was produced by tumor cell implantation (TCI) to the tibia in rats. Continuous feeding of Lactobacillus rhamnosus GG (LGG) was used to modulate the gut microbiota. Mechanical allodynia, bone destruction, fecal microbiota, and neurochemical changes in the primary dorsal root ganglion (DRG) and the spinal dorsal horn (DH) were assessed.

Results

LGG supplementation (109 CFU/rat/day) delayed the production of BCP for 3–4 days and significantly alleviated mechanical allodynia within the first 2 weeks after TCI. TCI-induced proinflammatory cytokines TNF-α and IL-β in the DH, and TCI-induced bone destruction in the tibia were both significantly reduced following LGG supplementation examined on day 8 after TCI. Meanwhile, we found that LGG supplementation, in addition to inhibiting TCI-induced pain, resulted in a significantly increased expression of the μ-opioid receptor (MOR) in the DH, but not in the DRG. LGG supplementation significantly potentiated the analgesic effect of morphine. Furthermore, LGG supplementation led to an increase in butyrate levels in the feces and serum and a decrease in histone deacetylase 2 (HDAC2) expression in the DH. Feeding TCI-rats with sodium butyrate solution alone, at a dose of 100 mg/kg, resulted in decreased pain, as well as decreased HDAC2 expression and increased MOR expression in the DH. The increased expression of MOR and decreased HDAC2 were also observed in neuro-2a cells when we treated the cells with serum from TCI rats with supplementation of LGG or sodium butyrate.

Discussion

This study provides evidence that reshaping the gut microbiota with probiotics LGG can delay the onset of cancer pain. The butyrate-HDAC2-MOR pathway may be the underlying mechanism for the analgesic effect of LGG. These findings shed light on an effective, safe, and non-invasive approach for cancer pain control and support the clinical implication of probiotics supplementation for patients with BCP.
Adherence and eating experiences differ between participants following a flexitarian diet including red meat or a vegetarian diet including plant-based meat alternatives: findings from a 10-week randomised dietary intervention trial
Authors: Gillies Nicola A. , Worthington Anna , Li Larissa , Conner Tamlin S. , Bermingham Emma N. , Knowles Scott O. , Cameron-Smith David , Hannaford Rina , Braakhuis Andrea
Published: June 2023

Background

Flexitarian, vegetarian and exclusively plant-based diets are increasingly popular, particularly amongst young adults. This is the first randomised dietary intervention to investigate the health, wellbeing, and behavioural implications of consuming a basal vegetarian diet that additionally includes low-to-moderate amounts of red meat (flexitarian) compared to one containing plant-based meat alternatives (PBMAs, vegetarian) in young adults (ClinicalTrials.gov NCT04869163). The objective for the current analysis is to measure adherence to the intervention, nutrition behaviours, and participants’ experience with their allocated dietary group.

Methods

Eighty healthy young adults participated in this 10-week dietary intervention as household pairs. Household pairs were randomised to receive either approximately three serves of red meat (average of 390 g cooked weight per individual, flexitarian group) or PBMAs (350–400 g per individual, vegetarian group) per week on top of a basal vegetarian diet. Participants were supported to adopt healthy eating behaviours, and this intervention was developed and implemented using a behaviour change framework. Adherence (eating allocated red meat or PBMA, abstaining from animal-based foods not provided by researchers) was continuously monitored, with total scores calculated at the end of the 10-week intervention period. Eating experiences were measured by the Positive Eating Scale and a purpose-designed exit survey, and a food frequency questionnaire measured dietary intake. Analyses used mixed effects modeling taking household clustering into account.

Results

The total average adherence score was 91.5 (SD = 9.0) out of a possible 100, with participants in the flexitarian group scoring higher (96.1, SD = 4.6, compared to 86.7, SD = 10.0; p < 0.001). Those receiving red meat were generally more satisfied with this allocation compared to those receiving the PBMAs, even though a leading motivation for participants joining the study was an opportunity to try plant-based eating (35% expressed that their interest in taking part was related to trying plant-based eating). Participants in both intervention groups had increased vegetable intake (p < 0.001), and reported more positive eating experiences (p = 0.020) and satisfaction with eating (p = 0.021) at the end of the 10-week intervention relative to baseline values.

Conclusion

Methods to encourage engagement with the trial were successful, as participants demonstrated excellent adherence to the intervention. Observed differences in participants’ adherence and experiences between flexitarian and vegetarian groups holds implications for the adoption of healthy, sustainable dietary patterns beyond this study alone.
A phase II randomized clinical trial to assess toxicity and quality of life of breast cancer patients with hypofractionated versus conventional fractionation radiotherapy with regional nodal irradiation in the context of COVID-19 crisis
Authors: Gil Gabriel Oliveira Bernardes , de Andrade Warne Pedro , Diniz Paulo Henrique Costa , Cantidio Farley Soares , Queiroz Izabella Nobre , Gil Maria Luísa Braga Vieira , Almeida Conceição Aparecida Medeiros , Caldeira Paola Palmer Reis , Regalin Marcos , Silva-Filho Agnaldo Lopes
Published: June 2023

Purpose

This study, conducted during the COVID-19 crisis, primarily aimed to compare the acute toxicity between conventional fractionated radiation therapy (CF-RT) with hypofractionated radiation therapy (HF-RT) among patients who underwent breast-conserving surgery or mastectomy in whom breast or chest wall and regional nodal irradiation (RNI) were indicated. The secondary endpoints were both acute and subacute toxicity, cosmesis, quality of life, and lymphedema features.

Methods

In this open and non-inferiority randomized trial, patients (n = 86) were randomly allocated 2:1 in the CF-RT arm (n = 33; 50 Gy/25 fractions ± sequential boost [10 Gy/5 fractions]) versus the HF-RT arm (n = 53; 40 Gy/15 fractions ± concomitant boost [8 Gy/15 fractions]). Toxic effects and cosmesis evaluation used the Common Terminology Criteria for Adverse Events, version 4.03 (CTCAE) and the Harvard/National Surgical Adjuvant Breast and Bowel Project (NSABP)/Radiation Therapy Oncology Group (RTOG) scale. For the patient-reported quality of life (QoL), the European Organisation for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30) and the breast cancer-specific supplementary questionnaire (QLQ-BR23) were used. Lymphedema was assessed by comparing volume differences between the affected and contralateral arms using the Casley–Smith formula.

Results

Grade 2 and grade 3 dermatitis were lower with HF-RT than with CF-RT (28% vs. 52%, and 0% vs. 6%, respectively; p = 0.022). HF-RT had a lower rate of grade 2 hyperpigmentation (23% vs. 55%; p = 0.005), compared to CF-RT. No other differences in overall rates of physician-assessed grade 2 or higher and grade 3 or higher acute toxicity between HF-RT and CF-RT were registered. There was no statistical difference between groups regarding cosmesis, lymphedema rate (13% vs. 12% HF-RT vs. CF-RT; p = 1.000), and functional and symptom scales, during both the irradiation period and after 6 months of the end of treatment. The results revealed that the subset of patients up to 65 years or older did not show a statistical difference between both arm fractionation schedules (p > 0.05) regarding skin rash, fibrosis, and lymphedema.

Conclusion

HF-RT was non-inferior to CF-RT, and moderate hypofractionation showed lower rates of acute toxicity, with no changes in quality-of-life outcomes.

Clinical trial registration

ClinicalTrials.gov, identifier NCT 40155531.
Integrated analysis of single-cell and bulk RNA-sequencing reveals tumor heterogeneity and a signature based on NK cell marker genes for predicting prognosis in hepatocellular carcinoma
Authors: Li Shuo , Du Hongbo , Gan Da’nan , Li Xiaoke , Zao Xiaobin , Ye Yong’an
Published: June 2023

Background: Natural killer (NK) cells are a type of innate immune cell that recognize and eliminate tumor cells and infected cells, without prior sensitization or activation. Herein, we aimed to construct a predictive model based on NK cell-related genes for hepatocellular carcinoma (HCC) patients and assess the feasibility of utilizing this model for prognosis prediction.

Methods: Single-cell RNA-seq data were obtained from the Gene Expression Omnibus (GEO) database to identify marker genes of NK cells. Univariate Cox and lasso regression were performed to further establish a signature in the TCGA dataset. Subsequently, qPCR and immunohistochemistry (IHC) staining were employed to validate the expression levels of prognosis signature genes in HCC. The effectiveness of the model was further validated using two external cohorts from the GEO and ICGC datasets. Clinical characteristics, prognosis, tumor mutation burden, immune microenvironments, and biological function were compared for different genetic subtypes and risk groups. Finally, molecular docking was performed to evaluate the binding affinity between the hub gene and chemotherapeutic drugs.

Results: A total of 161 HCC-related NK cell marker genes (NKMGs) were identified, 28 of which were significantly associated with overall survival in HCC patients. Based on differences in gene expression characteristics, HCC patients were classified into three subtypes. Ten prognosis genes (KLRB1, CD7, LDB2, FCER1G, PFN1, FYN, ACTG1, PABPC1, CALM1, and RPS8) were screened to develop a prognosis model. The model not only demonstrated excellent predictive performance on the training dataset, but also were successfully validated on two independent external datasets. The risk scores derived from the model were shown to be an independent prognosis factor for HCC and were correlated with pathological severity. Moreover, qPCR and IHC staining confirmed that the expression of the prognosis genes was generally consistent with the results of the bioinformatic analysis. Finally, molecular docking revealed favorable binding energies between the hub gene ACTG1 and chemotherapeutic drugs.

Conclusion: In this study, we developed a model for predicting the prognosis of HCC based on NK cells. The utilization of NKMGs as innovative biomarkers showed promise in the prognosis assessment of HCC.
1-Aminocyclopropane-1-Carboxylate Deaminase-Producing Plant Growth-Promoting Rhizobacteria Improve Drought Stress Tolerance in Grapevine (Vitis vinifera L.)
Authors: Duan Bingbing , Li Lin , Chen Guoqiao , Su-Zhou Chenxing , Li Yashan , Merkeryan Hasmik , Liu Wei , Liu Xu
Published: June 2023

Plant growth-promoting rhizobacteria (PGPRs) that produce 1-aminocyclopropane-1-carboxylate (ACC) deaminase are capable of reducing limits to plant growth due to water-deficient conditions. Here, seven PGPR strains that can produce ACC deaminase were successfully obtained from the rhizosphere soil of grapevine (Vitis vinifera L.) in arid regions of China. The strains belonged to three different genera: Pseudomonas, Enterobacter, and Achromobacter, according to their 16S rDNA sequencing analysis. A drought tolerance experiment revealed two PGPR strains (DR3 and DR6) with exceptionally high phosphate solubilization, nitrogen fixation, indoleacetic acid (IAA), and exopolysaccharides secretion potential. Both strains were selected for use in a pot experiment to evaluate their growth-promoting effects on grapevines under drought conditions. Each of these two PGPRs and their mixed inoculation into grapevines were expected to alleviate the comprehensive growth inhibition of grapevines caused by drought stress. The mixed inoculation was hypothesized to elicit the best growth-promoting effects. Inoculation with the PGPRs not only enhanced the root-adhering soil/root tissue ratios and soil aggregate stability, but it also increased the nitrogen and phosphorus levels in the soil and plant leaves. Further, inoculation with PGPRs significantly altered the plant height, biomass of shoot and root organs, relative water contents, and net photosynthetic rate of leaves, enabling grapevines to better cope with drought. Moreover, the contents of IAA, abscisic acid, and malondialdehyde in these grapevines under drought stress were significantly changed by PGPRs. They indirectly affected biochemical and physiological properties of grapevines to alleviate their drought stress. Taken together, these results demonstrate that the DR3 and DR6 PGPRs might be useful for effectively weakening the growth inhibition caused by drought in grapevines. The strains might also be applied as effective bioinoculants to maintain the quality of wine grapes.
Psychedelic unselfing: self-transcendence and change of values in psychedelic experiences
Authors: Kähönen Juuso
Published: June 2023

Psychedelic experiences have been shown to both facilitate (re)connection to one’s values and change values, including enhancing aesthetic appreciation, promoting pro-environmental attitudes, and encouraging prosocial behavior. This article presents an empirically informed framework of philosophical psychology to understand how self-transcendence relates to psychedelic value changes. Most of the observed psychedelic value changes are toward the self-transcendent values of Schwartz’s value theory. As psychedelics also reliably cause various self-transcendent experiences (STEs), a parsimonious hypothesis is that STEs change values toward self-transcendent values. I argue that STEs indeed can lead to value changes, and discuss the morally relevant process of self-transcendence through Iris Murdoch’s concept of “unselfing”. I argue that overt egocentric concerns easily bias one’s valuations. Unselfing reduces egocentric attributions of salience and enhances non-egocentric attention to the world, widening one’s perspective and shifting evaluation toward self-transcendent modes. Values are inherently tied to various evaluative contexts, and unselfing can attune the individual to evaluative contexts and accompanying values beyond the self. Understood this way, psychedelics can provide temporarily enhanced access to self-transcendent values and function as sources of aspiration and value change. However, contextual factors can complicate whether STEs lead to long-term changes in values. The framework is supported by various research strands establishing empirical and conceptual connections between long-term differences in egocentricity, STEs, and self-transcendent values. Furthermore, the link between unselfing and value changes is supported by phenomenological and theoretical analysis of psychedelic experiences, as well as empirical findings on their long-term effects. This article furthers understanding of psychedelic value changes and contributes to discussions on whether value changes are justified, whether they result from cultural context, and whether psychedelics could function as tools of moral neuroenhancement.
Decolonising the psychology curriculum: a perspective
Authors: Phiri Peter , Sajid Sana , Delanerolle Gayathri
Published: June 2023

Decolonisation seeks to reverse the impact of colonisation on minoritised groups. Governments, healthcare institutions, criminal justice and education systems have procedures and protocols deep-rooted in colonisation and operate through a western lens. Decolonisation reaches beyond increasing inclusivity and aims to re-establish history through the experiences and perspective of those most affected. As with many disciplines, core theories, practices and interventions within Psychology, an ethnocentric viewpoint has been used, continuously reinstated through its curriculum. With awareness around diversification and increase in varying demands, it is important that the Psychology curriculum evolves to suit the needs of its’ users. Many recommendations for decolonising the curriculum are trivial surface changes. These involve including required bibliography from diverse minority authors within the modules syllabuses or organising a one-off lecture or workshop from a minority ethnic speaker. Some universities have also suggested that lecturers participate in self-awareness practices to ensure they understand decolonisation to appropriately address it through their teaching, whilst others have provided checklists against which they can check the inclusivity of their modules. All these alterations fail to target the root of the problem. To properly reverse the effects of colonisation within the curriculum it would be necessary to re-evaluate the Westernised history that has been retold for years and teach past events through the experiences of those who suffered. Research into how decolonisation can occur in a structured and comprehensive way is necessary to enable the redress for abolition of colonial practices on a global scale.
Effects of the COVID-19 pandemic on mental health, working, and life situation of employees in the Swedish hospitality industry
Authors: Feltmann Kristin , Gustafsson Nina-Katri J. , Elgán Tobias H. , Gripenberg Johanna , Kvillemo Pia
Published: June 2023

Introduction

Previous studies reported that the coronavirus disease (COVID-19) pandemic has negatively affected the mental health of employees in the hospitality industry internationally, however, its effect in Sweden has not been studied. Unlike several other countries, Sweden never enforced a lockdown. Restaurants, bars, and hotels could remain open and host a limited number of guests but had to abide by certain restrictions.

Methods

A cross-sectional survey was distributed among hospitality industry employees containing questions regarding the perceived effects of the pandemic on the respondents’ working and life situations and their physical and psychological health. The sample consisted of 699 individuals, with a response rate of 47.9%.

Results

Although several respondents had been laid off or furloughed, the majority of the sample remained at the same employer. However, more than half of the respondents reported that their economic situation had deteriorated. Compared to before the pandemic, 38.1% experienced elevated levels of stress, 48.3% experienced elevated levels of worry, and 31.4% reported worsened mood. A deteriorating personal economy and difficulty in following COVID-19-related restrictions at work were associated with the worsening of these three mental health aspects. While the fear of becoming infected with COVID-19 was related to higher levels of stress, the fear of infecting others was related to higher levels of worry.

Conclusion

Although Sweden imposed less strict measures than most other countries, the personal economy and mental health of hospitality workers were negatively affected by the COVID-19 pandemic.
Health policy under the microscope: a micro policy design perspective
Authors: Capano Giliberto , Toth Federico
Published: June 2023

The comparative study of health policy has focused mainly on the macro-structural dimensions of health systems and reforms that have sought to change these organizational arrangements. Thus, a great deal of attention has been paid to the multiple models of insurance against sickness risks and various modes of organizing and financing healthcare providers. However, little attention has been paid to policy tools and policy design in the health policy domain. This research gap largely impedes a focus on the micro (granular) dimension of health policy, although this is the level at which health policies impact reality and thus deliver progress toward the expected goals. Such a focus on the micro dimension could not only allow a finer-grained comparison of how health systems work but also shed light on how capable health policies are of achieving the expected outcomes. This paper fills this gap by presenting an analytical framework capable of illuminating the granular dimension of policy design (the instrumental delivery package) and shows the analytical relevance of the framework by applying it to the designs of maximum waiting time guarantee and vaccination mandate policies.
Grand challenges in biomolecular condensates: structure, function, and formation
Authors: Hatters Danny M.
Published: June 2023

Biomolecular condensates describe concentrated nonstoichiometric assemblies of biomolecules that can form by a range of different mechanisms 1). Biomolecular condensates can arise by phase separation, which in biology involves the demixing of a water-soluble polymer into two co-existing phases: a polymer-dilute phase and a polymer-dense phase. Coacervates describe phase separation mediated by a third element, which may typically be a ligand (such as RNA) to the polymer (such as a protein) that undergoes phase separation. Protein aggregation into amyloids and amorphous aggregates, and the formation of RNA granules, represent other forms of biomolecular condensates. The assembly of proteins and other biomolecules into complexes is a fundamental feature for the execution of biological functions. Biomolecular condensates are a natural variation of the assembly theme. There is an incredible complexity and diversity to how condensates form, are regulated and are structured (reviewed recently in 2)). And there is incredible diversity to how condensates are used by nature to drive biological functions and how when their assemblies go wrong, they can drive disease mechanisms, such as amyloids in neurodegeneration.
Prebiotic capacity of novel bioengineered wheat arabinoxylans in a batch culture model of the human gut microbiota
Authors: Njoku Emmanuel N. , Mottawea Walid , Hassan Hebatoallah , Hammami Riadh
Published: June 2023

Arabinoxylan (AX) is an essential component of dietary fiber with potential prebiotic properties. However, owing to its complex structure, fermentation of AX by gut microbes is structure dependent. In this study, we evaluated the effect of bioengineered wheat AX on the metabolism and composition of gut microbiota using an in vitro fermentation model. We compared the effect of bioengineered AX with that of untreated AX and a control. Structurally modified AX did not significantly alter gut microbiome composition within 48 h of treatment; however, it enhanced the abundance of health-promoting bacterial taxa, such as Bacteroides, Bifidobacterium, Anaerofustis, and Eubacterium. Furthermore, the bioengineered AX significantly increased the level of acetate produced over 24 h. The amount of microbiota-generated butyrate was significantly increased 24 h after adding α-L-arabinofuranosidase-treated AX. AX treated with the α-L-arabinofuranosidase B25 enzyme induced higher levels of production of total short-chain fatty acids by the microbiota from four donors. The results of this study provide evidence that enzymatic structural modification of AX has the potential to modulate gut microbiome composition and metabolic activities.
Being where, with whom, and when it happens: spatial, interpersonal, and temporal presence while viewing live streaming of collegiate sports in virtual reality
Authors: Vincent Andrew , Frewen Paul
Published: June 2023

Introduction: Although virtual reality (VR) is most popularly known for its applications to gaming, other entertainment applications are increasingly being explored including in the sports media industry, but little research has so far examined the experiences induced by VR viewing of a live sporting event.

Materials and methods: Participants (n = 93) were university students who were approached in the context of a field study from a nearby community eatery area on the university campus to watch brief segments of a 360° live stream of the home games of their university volleyball and basketball teams both while wearing and not wearing an inexpensive smart-phone based head-mounted display (HMD). Immediately afterward, participants then reported on their relative experience of spatial, interpersonal, and temporal presence, as well as their satisfaction-preference with each of the two viewing modalities, in response to brief face-valid screening questions.

Results: The majority of participants experienced greater presence while wearing the VR headset, and approximately one in every two reported preferring to watch the games in VR. Participants’ experience of spatial presence independently correlated with preferring to watch the games in VR.

Discussion: Media vendors should offer VR viewing of sports including via inexpensive, smart-phone mediated VR as an additional, cost-effective alternative means of heightening fans’ experience of virtual presence at the games when fans are unable to go to the games in person.
Multi-instrumental detection of a fireball during Leonids of 2019
Authors: Szárnya Cs. , Chum J. , Podolská K. , Kouba D. , Koucká Knížová P. , Mošna Z. , Barta V.
Published: June 2023

During the 2019 Leonid meteor shower, the European Fireball Network recorded a bright fireball (meteor code: EN171119_041459) at 04:15:0.2 (UT) on 17 November 2019. The fireball appeared at coordinates 49.95°N 15.56°E at the height of 134.46 km, and disappeared at coordinates 50.23°N 15.26°E and at the height of 71.81 km. The ionization effect caused by the fireball appeared in the digisonde’s campaign measurements taken with a 2 ionogram/min time resolution at Průhonice station (50.00°N, 14.60°E). The trace appeared on the ionograms as a faint sporadic E-like layer, and the maximum ionization reached the upper limit of the measurement, 17 MHz. The trace persisted for 20 min on the ionograms, first appearing at 04:15:40 (UT) and finally disappearing at 04:35:40 (UT). The virtual height of the trace according to the ionograms appeared between 114 and 142 km, first it descended and then it ascended. Drift measurements were also taken with the digisonde every minute. Between 04:19:20 and 04:35:20 (UT), between altitudes of 122–142 km, 1-5 reflections were recorded on most SkyMaps. In addition, the Continuous Doppler Sounding developed by the Institute of Atmospheric Physics CAS also recorded the ionization signature of the fireball between 04:18 and 04:30 (UT) on 2 of the 3 sounding paths operating at 4.65 MHz. This is the first evidence that the plasma trail of a documented fireball can be detected by a DPS-4D digisonde (not only on ionograms, but also by drift measurements) and by the Continuous Doppler Sounding system.
Pasireotide Versus Octreotide in Preventing Complications After Simultaneous Pancreas-Kidney Transplantation
Authors: Ahopelto Kaisa , Bonsdorff Akseli , Grasberger Juulia , Lempinen Marko , Nordin Arno , Helanterä Ilkka , Sallinen Ville
Published: June 2023

In elective pancreatic surgery, somatostatin-analogues pasireotide and octreotide are variably used to reduce postoperative complications, but knowledge on their role in pancreas transplantation is limited. This study compared pasireotide and octreotide for their association with complications after simultaneous pancreas-kidney transplantation (SPK). This retrospective study included consecutive patients undergoing SPK’s from July 2013 to July 2022. Between July 2013 and April 2020, octreotide was administered 0.1 mg s.c. once daily and between May 2020 and July 2022 pasireotide was administered 0.9 mg twice daily, both until third postoperative day. Complications within 90 days postoperatively were collected, and reoperation rate and Comprehensive Complication index (CCI) ≥ 33.7 (morbidity equal to one reoperation) were used as primary outcomes. Of the 213 patients undergoing SPK, 150 patients received octreotide and 63 pasireotide. Baseline characteristics were comparable. Reoperation rate was 25.3% (n = 38) and 17.5% (n = 11) (p = 0.213) and rate of CCI ≥ 33.7 was 40.7% (n = 61) and 30.2% (n = 19) (p = 0.148) in octreotide and pasireotide groups, respectively. When adjusted with donor BMI, pancreas donor risk index, and donor sex, receiving pasireotide translated into OR 0.49 (95% CI: 0.25–0.96 p = 0.037) for CCI ≥ 33.7. Pasireotide was independently associated with lower postoperative morbidity within 90 days of SPK compared to octreotide.
Efficient Method for Continuous IoT Data Stream Indexing in the Fog-Cloud Computing Level
Authors: Khettabi Karima , Kouahla Zineddine , Farou Brahim , Seridi Hamid , Ferrag Mohamed
Published: June 2023

Internet of Things (IoT) systems include many smart devices that continuously generate massive spatio-temporal data, which can be difficult to process. These continuous data streams need to be stored smartly so that query searches are efficient. In this work, we propose an efficient method, in the fog-cloud computing architecture, to index continuous and heterogeneous data streams in metric space. This method divides the fog layer into three levels: clustering, clusters processing and indexing. The Density-Based Spatial Clustering of Applications with Noise (DBSCAN) algorithm is used to group the data from each stream into homogeneous clusters at the clustering fog level. Each cluster in the first data stream is stored in the clusters processing fog level and indexed directly in the indexing fog level in a Binary tree with Hyperplane (BH tree). The indexing of clusters in the subsequent data stream is determined by the coefficient of variation (CV) value of the union of the new cluster with the existing clusters in the cluster processing fog layer. An analysis and comparison of our experimental results with other results in the literature demonstrated the effectiveness of the CV method in reducing energy consumption during BH tree construction, as well as reducing the search time and energy consumption during a k Nearest Neighbor (kNN) parallel query search.
Adult-Child Caregivers’ Family Communication Experiences after an Older Parent’s Blood Cancer Diagnosis: A Survey Exploring Their Openness, Avoidance, and Social Support
Authors: Wright Kevin B. , Bylund Carma L. , Vasquez Taylor S. , Mullis M. Devyn , Sae-Hau Maria , Weiss Elisa S. , Bagautdinova Diliara , Fisher Carla L.
Published: June 2023

Adult-child caregivers of an aging parent living with a blood cancer describe struggling to communicate with one another and within the family system. They may avoid critical care conversations, which may impede care and their ability to receive social support. We examined what approaches adult-child caregivers of a parent diagnosed with a blood cancer use to enhance their family communication, the topics they find most challenging to discuss, and the roles of openness and support. We used qualitative and quantitative approaches to analyze data from a larger online survey study. In partnership with the Leukemia & Lymphoma Society, we recruited 121 adult-child caregivers. Responses to one open-ended item were analyzed to capture strategies used to enhance communication with their parent and family. They reported utilizing digital communication modalities, prioritizing frequent communication, engaging in openness, establishing boundaries, kinkeeping, and enacting support. Within the quantitative data, we further explored two of these themes (openness and support) and their relationships to other variables using t-tests and regression analysis. Adult-child caregivers and diagnosed parents avoid talking about mortality and negative feelings. Openness in the family about cancer was linked to caregivers’ perceptions of receiving social support. Findings demonstrate that cultivating openness between midlife adult children and diagnosed parents may enhance opportunities to receive support.
Stratification of Tamoxifen Synergistic Combinations for the Treatment of ER+ Breast Cancer
Authors: Zboril Emily K. , Grible Jacqueline M. , Boyd David C. , Hairr Nicole S. , Leftwich Tess J. , Esquivel Madelyn F. , Duong Alex K. , Turner Scott A. , Ferreira-Gonzalez Andrea , Olex Amy L. , Sartorius Carol A. , Dozmorov Mikhail G. , Harrell J. Chuck
Published: June 2023

Breast cancer alone accounts for the majority of cancer deaths among women, with the most commonly diagnosed subtype being estrogen receptor positive (ER+). Survival has greatly improved for patients with ER+ breast cancer, due in part to the development of antiestrogen compounds, such as tamoxifen. While treatment of the primary disease is often successful, as many as 30% of patients will experience recurrence and metastasis, mainly due to developed endocrine therapy resistance. In this study, we discovered two tamoxifen combination therapies, with simeprevir and VX-680, that reduce the tumor burden in animal models of ER+ breast cancer more than either compound or tamoxifen alone. Additionally, these tamoxifen combinations reduced the expression of HER2, a hallmark of tamoxifen treatment, which can facilitate acquisition of a treatment-resistant phenotype. These combinations could provide clinical benefit by potentiating tamoxifen treatment in ER+ breast cancer.
Revealing the Individual Effects of Firing Temperature and Chemical Composition on Raman Parameters of Celadon Glaze
Authors: Zhao Lan , Zhang Yunjun
Published: June 2023

The Raman polymerization index (or IP value) is often used as a positive indicator of the firing temperature of the glazes of ancient ceramics. Previous studies have also reported that the IP value was negatively correlated with the chemical composition of the glaze. However, these findings were derived from data on the potential integrative effects of temperature and composition. To explore their individual effects, we prepared celadon glaze samples with controlled composition and firing temperatures. Particularly, according to the typical content of K2O and CaO in celadon glaze, four categories, or, in total, fifteen compositional formulations, were designed, and each formulation was fired at multiple temperatures (from 1180 to 1250 °C by 10 °C). The chemical compositions and the glassy matrix of samples were analyzed by an energy-dispersive X-ray fluorescence spectrometer and Raman spectroscopy, respectively. A positive correlation between firing temperature and IP value (correlation coefficient = 0.56) was detected only in the samples with low contents of K2O and CaO. However, no significant correlation was found when combining the samples with broad variation in chemical composition. Additionally, both the K2O content and CaO content were negatively related to the IP value, with regression coefficients of −9.645 and −5.332, respectively. Our results help to clarify the technology of ancient ceramic production and to improve its preservation.
Fluorescent Anemones in Japan—Comprehensive Revision of Japanese Actinernoidea (Cnidaria: Anthozoa: Actiniaria: Anenthemonae) with Rearrangements of the Classification
Authors: Izumi Takato , Fujii Takuma , Yanagi Kensuke , Fujita Toshihiko
Published: June 2023

Actinernoidea is a superfamily of the suborder Anenthemonae of the order Actiniaria, subclass Hexacorallia. This superfamily has been diagnosed by a peculiar endocoeletic mesenterial arrangement and included two families, Actinernidae and Halcuriidae. Although the monophyly of this superfamily is anticipated based on preceding molecular phylogenetic works, the relationship between these two families was not certain because of the rarity of actinernoidean anemones. We conducted comprehensive sampling in Japan, where the highest diversity of actinernoideans is known, and conducted phylogenetic analyses using nuclear and mitochondrial gene markers. According to the comprehensive analyses, both Actinernidae and Halcuriidae were not indicated as monophyletic but rather as poly- or paraphyletic. Based on our phylogeny reconstruction, we propose a new classification for Actinernoidea composed of three families, including Isactinernidae fam. nov., and seven genera, including Isohalcurias gen. nov. We also describe four new species, Halcurias hiroomii sp. nov., H. fragum sp. nov., Isohalcurias citreum sp. nov., and I. malum sp. nov.; and propose a new combination, Isohalcurias carlgreni comb. nov. This work is the first study of Actinernoidea that comprehensively analyzes its phylogeny and rearranges its classification, showing that there is highly divergent fauna in the seas around Japan.
Assessing the Effectiveness of Masking and Encryption in Safeguarding the Identity of Social Media Publishers from Advanced Metadata Analysis
Authors: Khader Mohammed , Karam Marcel
Published: June 2023

Machine learning algorithms, such as KNN, SVM, MLP, RF, and MLR, are used to extract valuable information from shared digital data on social media platforms through their APIs in an effort to identify anonymous publishers or online users. This can leave these anonymous publishers vulnerable to privacy-related attacks, as identifying information can be revealed. Twitter is an example of such a platform where identifying anonymous users/publishers is made possible by using machine learning techniques. To provide these anonymous users with stronger protection, we have examined the effectiveness of these techniques when critical fields in the metadata are masked or encrypted using tweets (text and images) from Twitter. Our results show that SVM achieved the highest accuracy rate of 95.81% without using data masking or encryption, while SVM achieved the highest identity recognition rate of 50.24% when using data masking and AES encryption algorithm. This indicates that data masking and encryption of metadata of tweets (text and images) can provide promising protection for the anonymity of users’ identities.
Windowed Joint Detection and Decoding with IR-HARQ for Asynchronous SCMA Systems
Authors: Guan Mengsheng , Zhu Min , Bai Baoming
Published: June 2023

To improve the decoding performance of asynchronous sparse code multiple access (SCMA) systems over additive white Gaussian noise (AWGN) channels, this paper proposes a novel windowed joint detection and decoding algorithm for a rate-compatible (RC), LDPC code-based, incremental redundancy (IR) hybrid automatic repeat quest (HARQ) scheme. Since incremental decoding can exchange information iteratively with the detections made at previous consecutive time units, we propose a windowed joint detection and decoding algorithm. The extrinsic information exchanging process is performed between the decoders and the previous w detectors at different consecutive time units. Simulation results show that the sliding-window IR-HARQ scheme for the SCMA system outperforms the original IR-HARQ scheme with a joint detection and decoding algorithm. The throughput of the SCMA system with the proposed IR-HARQ scheme is also improved.
Entropy-Based Statistics and Their Applications
Authors: Zhang Zhiyi
Published: June 2023

During the last few decades, research activity in modeling the properties of random systems via entropies has grown noticeably across a wide spectrum of fields [...]
The Role of Local Government in the Bottom-Up Energy Transformation of Poland on the Example of the Lower Silesian Voivodeship
Authors: Struś Mirosław , Kostecka-Jurczyk Daria , Marak Katarzyna
Published: June 2023

This article focuses on the role of local government in energy transition. The aim of this article is to answer the question of whether local government authorities undertake actions aimed at the energy transformation of the region. This article is based on both literature studies and independent research. The empirical research was carried out in the Lower Silesian Voivodeship, located in Southwestern Poland. This region was chosen because it experienced the negative effects of economic transformation (liquidation of the Lower Silesian Coal Basin). Two hypotheses (H1 and H2) were adopted in the article. H1 assumes that in Polish conditions, bottom-up energy transformation requires the involvement of local authorities, and they should act as both initiators and shareholders of energy cooperatives. According to H2, local authorities participate in the energy transition to a limited extent. According to the conducted surveys, there has been no investment in wind farms, hydroelectric power plants or biogas plants. Communes are not interested in large, capital-intensive investments, limiting themselves to local actions with a small spatial range and small economic significance, although they are aware of the advantages of RES.
How to Enhance Energy Services in Informal Settlements? Qualitative Comparison of Renewable Energy Solutions
Authors: Besner Rebekka , Mehta Kedar , Zörner Wilfried
Published: June 2023

More than half of the urban population of Sub-Saharan Africa lives in informal housing conditions. While urban areas are, in general, characterized by a high electrification rate, residents of informal settlements are still affected by energy poverty, the use of traditional energy sources and unreliable electricity supply. The aim of the study is to give an overview of different renewable-energy-based solutions which are able to improve local energy provision. These are Solar Home Systems, Mini-Grids, and Energy-Hubs. The technologies are compared to another option for improving energy supply, namely Grid Expansion. The analysis is based on 24 Key Performance Indicators, which can be classified into technical, economic, environmental, social, and political dimensions. The selection of indicators is based on the challenges prevalent in informal settlements that impede a comprehensive, sustainable energy supply. The literature-based indices are used to determine which of the four technologies is a suitable solution for minimizing the challenges prevailing in informal settlements. The resulting matrix provides a holistic comparison and serves as a decision aid in selecting the appropriate technology for future projects in informal settlements, depending on local conditions and the needs of the population. The results show that the Energy-Hub is a valid alternative for energy supply improvement in Informal Settlements.
Validation of the CFD Tools against In-House Experiments for Predicting Condensing Steam Flows in Nozzles
Authors: Shabani Sima , Majkut Mirosław , Dykas Sławomir , Smołka Krystian , Lakzian Esmail , Zhang Guojie
Published: June 2023

The issues addressed in this work concern the condensing steam flows as a flow of a two-phase medium, i.e., consisting of a gaseous phase and a dispersed phase in the form of liquid droplets. The two-phase character and the necessity to treat steam as a real gas make the numerical modeling of the flow in the last steam turbine channels very difficult. There are many approaches known to solve this problem numerically, mainly based on the RANS method with the Eulerian approach. In this paper, the two Eulerian approaches were compared. In in-house CFD code, the flow governing equations were defined for a gas–liquid mixture, whereas in ANSYS CFX code, individual equations were defined for the gas and liquid phase (except momentum equations). In both codes, it was assumed that there was no velocity slip between phases. The main aim of this study was to show how the different numerical schemes and different governing equations can affect the modeling of wet steam flows and how difficult and sensitive this type of computation is. The numerical results of condensing steam flows were compared against in-house experimental data for nozzles determined at the Department of Power Engineering and Turbomachinery of the Silesian University of Technology. The presented experimental data can be used as a benchmark test for researchers to model wet steam flows. The geometries of two half nozzles and an International Wet Steam Experimental Project (IWSEP) nozzle were used for the comparisons. The static pressure measurements on the walls of the nozzles, the Schlieren technique, and the droplet size measurement were used to qualitatively identify the location of the condensation onset and its intensity. The CFD results obtained by means of both codes showed their good capabilities in terms of proper prediction of the condensation process; however, there were some visible differences in both codes in the flow field parameters. In ANSYS CFX, the condensation wave location in the half nozzles occurred much earlier compared to the experiments. However, the in-house code showed good agreement with the experiments in this region. In addition, the results of the in-house code for the mean droplet diameter in the IWSEP nozzle were closer to the experimental data.
Fuzzy AHP Assessment of Urban Parks Quality and Importance in Novi Sad City, Serbia
Authors: Srdjevic Bojan , Lakicevic Milena , Srdjevic Zorica
Published: June 2023

This paper proposes an AHP approach that utilizes the fuzzy extent model to prioritize five city parks based on their present quality and projected importance for Novi Sad City, the capital of Vojvodina Province, in Serbia. The study involved an expert evaluation of a set of eight criteria to identify the most relevant subset of criteria for a detailed park assessment. The park evaluation took into account uncertainties (fuzziness), the expert’s risk tolerance, and different levels of optimism and pessimism. The obtained results could serve when defining upcoming city plans and management agendas related to green areas in the city. The proposed fuzzy-based methodology can be extended to group decision-making scenarios by involving more experts and stakeholder representatives. The park weights obtained through the fuzzy AHP methodology described in this paper can aid city planners and politicians in the strategic allocation of financial, organizational, and human resources for parks.
Evaluation of Litter Flammability from Dominated Artificial Forests in Southwestern China
Authors: Li Shuting , Zhang Zihan , Zheng Jiangkun , Hou Guirong , Liu Han , Cui Xinglei
Published: June 2023

Southwestern China has a large area of artificial forests and has experienced massive environmental and social losses due to forest fires. Evaluating the flammability of fuels from dominated forests in this region can help assess the fire risk and predict potential fire behaviors in these forests, thus guiding forest fire management. However, such studies have been scarcely reported in this region. In this study, the flammability of litter from nine forest types, which are common in southwestern China, was evaluated by measuring organic matter content, ignition point, and calorific value. All these flammability characteristics of fuels varied significantly across forest types. By using principal component analysis and K-means clustering, litters were classified into three groups: highly susceptible to ignition with low fire intensity (Pinus densata, Pinus densata-Populus simonii, Pinus yunnanensis, Larix gmelini, Pinus armandii), less susceptible to ignition with high fire intensity (Abies fabri-Populus simonii), and median ignitibility and fire intensity (Abies fabri, Abies fabri-Picea asperata, Platycladus orientalis). Our study can help predict the risk and intensity of fires in the studied forests and serve as a source of information for fire management in southwestern China.