bluuebunny/crossref_metadata_2025 huggingface dataset:
Flouting Maxim in Wednesday Series
Authors: Mawarni Titis , Wibowo Agung Prasetyo
Published: January 2024

Flouting maxim is happened when the speakers blatantly fail to follow the cooperative principles and convey the meaning to the listeners. The objectives of this research are to find out the types of flouting maxim in Wednesday series and to identify the type of flouting maxim that most frequently used in Wednesday series used Grice (1975) theory. This research used descriptive qualitative method. The result showed that the researcher found 4 types of flouting maxim, they were flouting maxim of quantity for 40 (38%) data, flouting maxim of quality for 23 (22%) data, flouting maxim of relation for 21 (20%) data, and flouting maxim of manner for 21 (20%) data. The dominant flouting maxim frequently occurred in the Wednesday series is the flouting maxim of quantity for 40 (38%) data.
Expressive Illocutionary Speech Acts Used in Queen Charlotte: A Bridgerton Story Series
Authors: Amani Adibah Saesa , Setiarini Ni Luh Putu
Published: January 2024

This research discusses expressive speech acts identified in the Queen Charlotte: A Bridgerton Story series. The objective of this research are to find out the types of expressive speech acts and the most dominant types of expressive speech acts used in the Queen Charlotte: A Bridgerton Story series. The method used in this research was descriptive-qualitative. This research used theory from Searle and Vanderken (1985) to analyze the data. The data in this study were obtained from the utterances used by the character in Queen Charlotte: A Bridgerton Story. The results of this research showed that there are 109 data points found, namely 12 data of apology, 14 data of thanks, three data of condole, two data of condolences, 10 data of complaint, 12 data of lament, 15 data of protest, five data of deplore, six data of boast, 13 data of compliment, six data of praise, and 11 data of welcome (greet). With these data, the expressive speech act of protest is the most types of expressive speech act used in the Queen Charlotte: A Bridgerton Story series.
Sistem Pendukung Keputusan Menggunakan Metode Profile Matching dalam Pemilihan Karyawan Terbaik pada Apotek Generik
Authors: Chairrah Fita , Kusmanto Tria Hadi , Afrizal Thomas
Published: January 2024

Di zaman yang serba digital ini segala sesuatu dilakukan dengan digitalisasi dalam proses transaksi ini. Salah satu nya adalah didalam perysahaan, yaitu penentuan karyawan terbaik . Dalam penentuan karyawan terbaik pada PT Apotek Generik Tanjung Barat. Terdapat beberapa faktor kriteria dalam pengambilan keputusan sehingga mendapatkan keputusan yang tepat. Kriteria nya adalah sikap kerja, kepribadian, dan tanggung jawab. Pada saat ini proses penilaian kinerja karyawan di PT Apotek Generik Tanjung Barat belum ada sehingga tidak dapat menentukan keputusan karyawan terbaik pada PT Apotek Generik Tanjung Barat. Untuk itu Sistem Pendukung Keputusan (SPK) sangat membantu dalam hal pengambilan keputusan yang dibuat, kemudian dianalisis dengan menggunakan metode profile matching. Dengan menggunakan metode profile matching maka PT Apotek Generik Tanjung Barat bisa membuat keputusan dalam penilaian karyawan terbaik yang sesuai dengan kemampuan. Penelitian ini adalah untuk mengetahui ranking/bobot nilai dalam penilaian karyawan terbaik di PT Apotek Generik Tanjung Barat.
Sistem Pemilihan Sales Terbaik dengan Metode Topsis di PT Dahua Vision Technology Indonesia
Authors: Fadillah Febi Abdul , Rahmah Dewi Leyla , Marlina Dwi
Published: January 2024

PT Dahua Vision Technology Indonesia sebagai perusahaan Information Technology yang bergerak di bidang Security/Surveillance System telah banyak menjual solusi dan produknya, terutama perangkat CCTV (Closed Circuit Television). Dalam proses bisnisnya peran tim sales dilapangan sangat penting yakni untuk menawarkan dan meningkatkan penjualan. Oleh karena, perlu adanya apresiasi untuk memotivasi dan meningkatkan kinerja setiap sales. Maka PT Dahua Vision Technology Indonesia memerlukan suatu metode dan sistem pendukung keputusan untuk memilih sales terbaik. Metode yang dapat digunakan adalah TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution), yaitu metode yang akan mencari alternatif terbaik dimana alternatif tersebut memiliki jarak terdekat dari solusi positif yang ideal, serta memiliki jarak terjauh dari solusi negatif yang diukur dari sudut pandang perhitungan geometris. Sehingga PT Dahua Vision Indonesia memiliki cara penentuan sales terbaik yang terukur serta sistematis dengan kriteria yang relevan yang akan menghindari perhitungan yang tidak tepat dan susbjektivitas dalam menilai kinerja sales. Selain itu, sistem pemilihan sales terbaik dengan metode TOPSIS ini, dapat membantu meningkatkan efisiensi penentuan sales terbaik dan memberikan pengelolaan data maupun output laporan yang terstruktur. Kata Kunci : Sistem Pendukung Keputusan, Pemilihan Sales Terbaik, Metode TOPSIS, Java, Netbeans
Sistem Pendukung Keputusan Penilaian Pemilihan Karyawan Terbaik di PT Hoki Moro Menggunakan Metode AHP
Authors: Dinda Shafira Risqi , Pravitasari Norma , Farkhatin Naely
Published: January 2024

Tujuan dari penilitian ini adalah untuk mengembangkan sistem pendukung keputusan pemilihan karyawan terbaik yang sudah ada supaya mempermudah pendataan dan proses pemilihan karyawan terbaik. Metodologi penelitian yang digunakan dalam sistem pengolahan data adalah metode studi pustaka yaitu pengumpulan data yang dilakukan dengan mengambil data-data dari berbagai buku diperpustakaan, jurnal serta buku-buku lainnya yang dapat dijadikan landasan untuk menganalisa masalah yang dapat dibahas dalam penelitian, serta metode studi lapangan yaitu dengan melakukan pengamatan secara langsung seperti wawancara dan observasi. Algoritma dalam penyelesaian masalah yang digunakan adalah Analytical Hierarchy Process. Hasil dari penelitian ini adalah adanya suatu perangkat aplikasi yang dibuat dengan bahasa pemrograman Java dan penyimpanan data menggunakan database dari MySQL sehingga proses pendataan dan pemilihan karyawan terbaik pada PT Hoki Moro Citra menjadi lebih efektif, efisien dan praktis.
PENDAMPINGAN GERAKAN LITERASI DAN NUMERASI DI SEKOLAH MELALUI PROGRAM MAHASISWA PENGABDI KAMPUS MENGAJAR DI SD SWASTA AL ITTIHADIYAH KANDANGAN KECAMATAN PEMATANG BANDAR KABUPATEN SIMALUNGUN
Authors: Anggraini Sinta Dea , Pulungan Nurbaiti Octiviani , Dewi Siska Erika , Wardani Hizmi
Published: January 2024

Kampus merdeka merupakan kegiatan dari kebijakan Menteri Pendidikan dengan mengajak mahasiswa untuk bekerjasama dalam kegiatan MBKM yang bertujuan untuk mengembangkan kreativitas dan inovasi kemampuan masing-masing mahasiswa disekolah, dengan kegiatan kampus mengajar dapat membantu mahasiswa untuk belajar menguasai berbagai keilmuan dan bertujuan untuk membantu mahasiswa untuk belajar mengembangkan bakat mahasiswa diluar kelas serta memberikan kesempatan kepada mahasiswa untuk belajar menjadi seorang guru didalam kelas maupun diluar kelas agar mahasiswa mempunyai bekal untuk kedepannya dan bisa berencana kedepannya harus bagaimana menjadi seorang guru yang profesional. Kegiatan ini berbentuk kegiatan pengabdian kepada sekolah yang dilakukan di SD Swasta Al Ittihadiyah Kandangan di Kecamatan Pematang Bandar Kabupaten Simalungun Sumatera Utara. Metode  kegiatan digunakan  yaitu metode yang bertahap yaitu tahap  rencana  kegiatan,  tahap  pelaksanaan  kegiatan,  dan  tahap  perbaikan  dan tindak lanjut. Adapun kegiatan yang dilakukan dalam pengapdian ini yaitu ada 3 kegiatan membantu proses literasi, membantu proses pembelajaran pelajaran Matematika (numerasi), dan membantu adaptasi teknologi serta membantu melakukan administrasi disekolah. Hasil analisis pelaksanaan program kampus mengajar yang melakukan gerakan literasi dan numerasi untuk membantu peserta didik SD Swasta Al Ittihadiyah Kandangan sudah tercapaia sesuai dengan tujuan dari Kampus Mengajar.
PKM KELOMPOK PEMUDA KARANG TARUNA DALAM MENGOLAH MINUMAN HERBAL DI BEDAHAN, SAWANGAN DEPOK UNTUK MENCIPTAKAN PELUANG USAHA BARU PASCA PANDEMI
Authors: Aqil Deden Ibnu , Gayatri Askardiya Mirza , Adhi Tony Margiyanto , Muzdalifah Muzdalifah , Walid Naufal Abdurrahman
Published: January 2024

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan kewirausahaan dan tanaman obat keluarga yang dilanjutkan dengan pelatihan keterampilan melalui praktek langsung bagi kelompok pemuda karang taruna di kelurahan Bedahan Sawangan Depok. Pemuda karang taruna masih merasa bingung dan belum percaya diri dalam memulai usaha. Dengan alasan tersebut tim pengabdian kepada masyarakat Universitas Indraprasta PGRI yang berjumlah 3 (tiga) dosen dibantu oleh 1 (satu) mahasiswa akan memberikan penyuluhan, pengetahuan, dan pelatihan kepada kelompok pemuda karang taruna di Bedahan Sawangan Depok.yang berjumlah sekitar 26 orang. Metode yang digunakan dalam pelaksanaan kegiatan ini adalah diawali dengan pemberian pengetahuan tentang kewirausahaan dan pengetahuan lingkungan termasuk pengetahuan tanaman obat yang rencananya akan dilakukan secara hibrida yaitu tatap muka dengan ikuti prokes dan online. Dilanjutkan dengan praktek langsung membuat minuman/ wedang herbal dan menetapkan harga jual. Bentuk luaran yang diharapkan adalah kelompok pemuda karang taruna di Bedahan adalah mendapatkan pengetahuan kewirausahaan sebagai pembekalan untuk menjadi pengusaha pemula, menambah pengetahuan dalam membuat minuman/ wedang herbal dari tanaman obat sebagai peluang usaha pasca pandemic dan dapat menetapkan harga jual produk wedang herbal.
PENDAMPINGAN PENYUSUNAN RENCANA PELAKSANAAN LAYANAN BIMBINGAN DAN KONSELING PADA GURU BIMBINGAN DAN KONSELING TINGKAT SEKOLAH MENENGAH KEJURUAN
Authors: Satrianta Hengki , Renata Dian , Nisa Afiatin
Published: January 2024

Penyusunan perangkat pembelajaran dan perangkat layanan bagi guru bidang studi dan guru Bimbingan dan Konseling (BK) senantiasa menjadi masalah dalam unjuk kinerja guru itu sendiri. Perubahan kurikulum yang mendorong perubahan administrasi perangkat menyebabkan guru menjadi kewalahan di lapangan. Khusus bagi guru BK perubahan kebijakan kurikulum menjadi Kurikulum Merdeka turut memunculkan masalah tersendiri. Guru BK tidak memiliki pedoman yang jelas dalam penyusunan Rencana Pelaksanaan Layanan (RPL). Untuk itu kegiatan pendampingan bagi guru BK dalam penyusunan RPL perlu dilakukan agar guru BK memiliki pandangan yang komprehensif mengenai RPL dalam Kurikulum Merdeka. Dalam pelaksanaannya kegiatan pendampingan dikemas dalam bentuk Pengabdian kepada Masyarakat yang dilangsungkan di SMK Negeri 34 Jakarta. Sasaran kegiatan ini adalah guru BK di Suku Dinas Pendidikan Wilayah II Jakarta Pusat. Pendampingan ini diselenggarakan melalui tahap perencanaan, pelaksanaan, evaluasi, dan tindak lanjut. Melalui kegiatan pendampingan diperoleh hasil bahwa: a) pemahaman guru BK dalam penyusunan RPL pada dasarnya belum optimal, b) kegiatan pendampingan memberikan pemahaman baru bagi guru BK dalam penyusunan RPL, dan c) masih tetap dibutuhkan kegiatan lanjutan dalam mendampingi guru BK dalam penyusunan RPL.
PELATIHAN IMPLEMENTASI MEDIA PEMBELAJARAN BERBASIS DIGITAL PADA GURU DI SMK YATINDO BEKASI
Authors: Rizkiyah Nur , Abdillah Agus , Nizar Ahmad
Published: January 2024

Kurang optimalnya capaian pembelajaran dapat disebabkan oleh salah satu faktor yakni media pembelajaran. Capaian pembelajaran yang belum optimal searah dengan kompetensi guru yang belum optimal pula. Seiring dengan perkembangan teknologi informasi dan komunikasi, maka sudah menjadi keniscayaan bahwa dalam bidang pendidikan pun harus mengikuti konstelasi zaman, termasuk media pembelajaran yang diterapkan. Media harus memiliki nilai kebaruan, adaptif, inovatif serta efektif dan efisien sehingga hasil belajar siswa optimal. Kompetensi guru yang relative rendah dalam penggunaan media pembelajaran berbasis digital, perlu ditingkatkan. Tujuan kegiatan yakni meningkatkan pengetahuan dan keterampilan guru SMK dalam mengimplementasikan media pembelajaran berbasis digital. Salah satu caranya adalah melalui kegiatan Pelatihan Penerapan Media Pembelajaran Berbasis Digital pada guru SMK. Kegiatan dilaksanakan di SMK Yatindo Bekasi dengan jumlah peserta keseluruhan sebanyak 25 guru, dari 3 program keahlian. Penyampaian materi pelatihan dilakukan dengan metode blanded learning yakni daring dan luring. Penyampaian materi daring seperti sajian materi disertai tugas-tugas. Penyampaian materi secara luring antara lain; presentasi materi, diskusi dan tugas-tugas lapangan. Dapat disimpulkan bahwa penyelenggaran pelatihan ini terlaksana dengan baik. Hal ini dapat ditinjau dari peningkatan pengetahuan dan keterampilan peserta dalam mengimplementasikan media pembelajaran berbasis digital pada pelaksanaan pembelajaran.
PEMERIKSAAN KESEHATAN GIGI DAN MULUT PADA ANAK DI PANTI ASUHAN BAITUS SYUKUR & TUNAS MELATI, BANDUNG
Authors: Yuniarti Yuniarti , Irasanti Siska Nia , Kurniasari Febriana
Published: January 2024

Kesehatan gigi dan mulut sangat penting untuk kesehatan secara keseluruhan dan kualitas hidup karena penyakit ini dapat menyebabkan masalah serius seperti rasa sakit, kesulitan mengunyah makanan, berbicara, tidur, penurunan nafsu makan, bahkan kematian. Pemeriksaan kondisi kesehatan gigi dan mulut khususnya pada anak-anak panti asuhan Baitus Syukur dan Tunas Melati perlu dilakukan untuk mencegah penyakit di daerah gigi dan mulut berkembang yang akhirnya dapat dapat mengganggu proses tumbuh kembang seorang anak.
MENINGKATKAN KREATIVITAS DALAM BENTUK WADAH POTENSI EKONOMI MELALUI KONTEN YOUTUBE DAN TIKTOK
Authors: Saripah Saripah , Sari Maemunah Nurmaya , Mashita Juni
Published: January 2024

Media Sosial sangat beragam saat ini. Tidak hanya sekadar untuk hiburan, namun bisa menjadi potensi ekonomi bagi berbagai pihak. Pembelajaran yang dilakukan pada lembaga pendidikan Taman Kanak-kanak tentu berbeda dengan pendidikan formal pada umumnya, karena pada pembelajaran di tingkat taman kanak-kanak pembelajaran akan dibuat semenarik mungkin untuk menarik minat dan motivasi anak untuk mau belajar sambil bermain. Pada RA Al-Hidayah, potensi ekonomi hanya didapatkan dari SPP anak didiknya saja, tanpa ada tambahan lain diluar pendapatan tetap tersebut. Pada kegiatan abdimas ini diadakan kegiatan workshop dalam rangka meningkatkan kreativitas dalam bentuk wadah potensi ekonomi melalui konten YouTube dan TikTok.
PENGARUH PENERAPAN PENDEKATAN TERPADU BERBASIS ACTIVE DEEP LEARNER EXPERIENCE (ADLX) DAN KARAKTER RELIGIUS TERHADAP SIKAP BERGOTONG–ROYONG SISWA
Authors: Isnawati Isnawati , Amprasto Amprasto , Sardjijo Sardjijo
Published: January 2024

Tujuan riset ini adalah guna menganalisis dampak pendekatan TERPADU Berbasis ADLX terhadap sikap bergotong royong; Untuk menganalisis pengaruh karakter religius terhadap sikap bergotong royong; dan Untuk menganalisis pengaruh interaksi pendekatan TERPADU Berbasis ADLX dan Karakter Religius terhadap sikap bergotong royong. Jenis riset yang dipakai yaitu dengan pendekatan kuantitatif, Metode yang dipakai adalah pendekatan eksperimen semu dengan menggunakan desain faktorial 2 X 2. Temuan riset ini adalah: 1) Pendekatan pembelajaran terpadu ADLX berpengaruh signifikan terhadap sikap kooperatif siswa SDIT Ibadurrahman. Akuisisi Sig adalah buktinya. 0,024 < 0,05 dan Fhitung = 5,409 > 3,15 2) Disposisi religius berpengaruh sangat signifikan terhadap sikap kooperatif siswa SDIT Ibadurrahman. Akuisisi Sig adalah buktinya. 0,000 < 0,05 dan Fhitung = 34,395 > 3,15 3) Metode pembelajaran ADLX INTEGRATED dan disposisi religius tidak berpengaruh signifikan terhadap sikap kooperatif siswa SDIT Ibadurrahman. Akuisisi Sig adalah buktinya. 0,514 > 0,05 dan Fhitung = 0,432 < 3,15. Dimana interaksi antara pendekatan pembelajaran TERPADU ADLX dan Karakter Religius mempunyai nilai rata-rata tertinggi yaitu 64,86.
NEED ANALYSIS OF BUSINESS ENGLISH FOR ECONOMIC EDUCATION UNDERGRADUATE STUDENTS
Authors: Desnaranti Laila , Putra Febby Pratama
Published: January 2024

Learning English is necessary for a variety of goals, not just for language fluency in general but also for more specific purposes (English for Specific Purposes). Business English is becoming more and more crucial as businesses demand that their employees speak multiple languages. The purpose of this research is to identify undergraduate students’ needs for business English using need analysis. The method that used in this research is descriptive qualitative approach. The researcher use questionnaire to find the undergraduate students’ need, lack, and want. The research result based on the questionnaire which can be concluded that learning English is essential for the undergraduate students and their motivation in learning English is to be able to communicate in formal or non-formal situation at business environments. The researchers came to the conclusion that the undergraduate students must enhance their english speaking ability because this is also one of their lack based on the questionnaire's findings. The result of this research will be used to develop a new syllabus and textbook for business English.
IMPLEMENTASI MANAJEMEN BIMBINGAN KONSELING DALAM MEMBANGUN SELF ACCEPTACE MELALUI LAYANAN INFORMASI DI MAN KOTA BINJAI
Authors: Utami Siti Rianti Rizki , Lubis Saiful Akhyar , Hadijaya Yusuf
Published: January 2024

Penelitian ini bertujuan untuk memperdalam pemahaman tentang implementasi manajemen bimbingan dan konseling dalam membangun self acceptance siswa melalui layanan informasi di Madrasah Aliyah Negeri (MAN) Kota Binjai. Dalam konteks ini, penelitian menggunakan pendekatan kualitatif untuk memberikan gambaran yang mendalam tentang bagaimana manajemen bimbingan dan konseling diimplementasikan untuk membantu siswa memperoleh self acceptance, atau penerimaan diri yang positif. Dalam upaya mendapatkan data yang akurat dan komprehensif, metode observasi, wawancara, dan studi dokumentasi digunakan sebagai alat pengumpulan informasi. Observasi memungkinkan peneliti untuk melihat secara langsung bagaimana layanan informasi dan manajemen bimbingan dan konseling dilaksanakan di lingkungan sekolah. Wawancara dengan para guru bimbingan dan konseling, serta siswa, memberikan pandangan yang berharga tentang perspektif mereka terhadap layanan ini. Sementara itu, studi dokumentasi membantu dalam memperoleh data terkait program-program yang telah dijalankan sebelumnya, serta evaluasi dan dokumentasi hasil dari layanan yang telah diberikan. Hasil penelitian menunjukkan bahwa pelaksanaan implementasi manajemen bimbingan dan konseling dalam membangun self acceptance siswa melalui layanan informasi di MAN Binjai berjalan dengan baik. Hal ini terlihat dari persiapan yang matang dari para guru bimbingan dan konseling dalam merancang program-program layanan yang relevan dan efektif. Mereka menyusun rencana pelaksanaan layanan dengan seksama, memastikan bahwa setiap langkah dijalankan dengan tepat dan terarah. Dalam layanan ini, guru bimbingan dan konseling berperan sebagai pendamping yang peduli, memberikan dukungan emosional, dan memberikan informasi yang relevan untuk membantu siswa meraih self acceptance yang positif.
 
Application of Genomic Data in Translational Medicine During the Big Data Era
Authors: Zhang Yun , Yu Jian , Xie Xiaoyan , Jiang Feng , Wu Chuyan
Published: January 2024

Advances in gene sequencing technology and decreasing costs have resulted in a proliferation of genomic data as an integral component of big data. The availability of vast amounts of genomic data and more sophisticated genomic analysis techniques has facilitated the transition of genomics from the laboratory to clinical settings. More comprehensive and precise DNA sequencing empowers patients to address health issues at the molecular level, facilitating early diagnosis, timely intervention, and personalized healthcare management strategies. Further exploration of disease mechanisms through identification of associated genes may facilitate the discovery of therapeutic targets. The prediction of an individual’s disease risk allows for improved stratification and personalized prevention measures. Given the vast amount of genomic data, artificial intelligence, as a burgeoning technology for data analysis, is poised to make a significant impact in genomics.
Identifying Autophagy-Associated Proteins and Chemicals with a Random Walk-Based Method within Heterogeneous Interaction Network
Authors: Huang FeiMing , Guo Wei , Chen Lei , Feng KaiYan , Huang Tao , Cai Yu-Dong
Published: January 2024

Background: Autophagy is instrumental in various health conditions, including cancer, aging, and infections. Therefore, examining proteins and compounds associated with autophagy is paramount to understanding cellular biology and the origins of diseases, paving the way for potential therapeutic and disease prediction strategies. However, the complexity of autophagy, its intersection with other cellular pathways, and the challenges in monitoring autophagic activity make the experimental identification of these elements arduous. Methods: In this study, autophagy-related proteins and chemicals were catalogued on the basis of Human Autophagy-dedicated Database. These entities were mapped to their respective PubChem identifications (IDs) for chemicals and Ensembl IDs for proteins, yielding 563 chemicals and 779 proteins. A network comprising protein–protein, protein–chemical, and chemical–chemical interactions was probed employing the Random-Walk-with-Restart algorithm using the aforementioned proteins and chemicals as seed nodes to unearth additional autophagy-associated proteins and chemicals. Screening tests were performed to exclude proteins and chemicals with minimal autophagy associations. Results: A total of 88 inferred proteins and 50 inferred chemicals of high autophagy relevance were identified. Certain entities, such as the chemical prostaglandin E2 (PGE2), which is recognized for modulating cell death-induced inflammatory responses during pathogen invasion, and the protein G Protein Subunit Alpha I1 (GNAI1), implicated in ether lipid metabolism influencing a range of cellular processes including autophagy, were associated with autophagy. Conclusions: The discovery of novel autophagy-associated proteins and chemicals is of vital importance because it enhances the understanding of autophagy, provides potential therapeutic targets, and fosters the development of innovative therapeutic strategies and interventions.
Unveiling the Intricacies of Autophagy in Asthma: Unraveling Novel Therapeutic Avenues
Authors: Peng Junjun , Lu Na , Hua Shucheng , Song Lei , Liu Han
Published: January 2024

Understanding the pathogenesis of different phenotypes of asthma, including glucocorticoid-dependent and glucocorticoid-resistant asthma, is crucial for the development of effective treatments. Autophagy, a fundamental cellular process involved in cell homeostasis, has been implicated in asthma, although the exact mechanisms remain unclear. Recent studies have identified autophagy activation in eosinophilic, neutrophilic, and paucigranulocytic asthma, providing novel insights into the disease. This comprehensive review examines the role of autophagy in the pathogenesis and treatment of asthma, with a focus on various cell types. The goal is to uncover potential therapeutic targets and innovative treatment modalities to improve patient outcomes in clinical settings.
Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease
Authors: Blagov Alexander , Postnov Anton , Sukhorukov Vasily , Popov Mikhail , Uzokov Jamol , Orekhov Alexander
Published: January 2024

Parkinson’s disease (PD) is characterized by the degeneration of the dopaminergic neurons of the corpus striatum, which can be caused by the disruption of processes of mitochondrial homeostasis, including mitophagy, mitochondrial fusion and division, mitochondrial transport, accumulation of reactive oxygen species (ROS), and calcium signaling. Dopaminergic neurons are particularly vulnerable to mitochondrial dysfunction due to their polarized and expanded structure and high bioenergy needs. The molecular basis of these disorders is manifested in mutations of mitochondrial homeostasis proteins. Understanding the functions of these proteins and the disorders caused by these mutations can be used to create therapeutics for the treatment of PD and diagnostic biomarkers of PD. A comprehensive analysis of research papers to identify promising therapeutic targets and drug compounds that target them, as well as biomarkers of mitochondrial dysfunction that can be used in clinical practice for the treatment of PD has been conducted in the current review. This practical approach advantageously emphasizes the difference between this work and other reviews on similar topics. The selection of articles in this review was carried out using the following keyword searches in scientific databases: PubMed, Google Scholar, NSBI, and Cochrane. Next, the most relevant and promising studies were re-selected.
Machine Learning for Detecting Atrial Fibrillation from ECGs: Systematic Review and Meta-Analysis
Authors: Xie Chenggong , Wang Zhao , Yang Chenglong , Liu Jianhe , Liang Hao
Published: January 2024

Background: Atrial fibrillation (AF) is a common arrhythmia that can result in adverse cardiovascular outcomes but is often difficult to detect. The use of machine learning (ML) algorithms for detecting AF has become increasingly prevalent in recent years. This study aims to systematically evaluate and summarize the overall diagnostic accuracy of the ML algorithms in detecting AF in electrocardiogram (ECG) signals. Methods: The searched databases included PubMed, Web of Science, Embase, and Google Scholar. The selected studies were subjected to a meta-analysis of diagnostic accuracy to synthesize the sensitivity and specificity. Results: A total of 14 studies were included, and the forest plot of the meta-analysis showed that the pooled sensitivity and specificity were 97% (95% confidence interval [CI]: 0.94–0.99) and 97% (95% CI: 0.95–0.99), respectively. Compared to traditional machine learning (TML) algorithms (sensitivity: 91.5%), deep learning (DL) algorithms (sensitivity: 98.1%) showed superior performance. Using multiple datasets and public datasets alone or in combination demonstrated slightly better performance than using a single dataset and proprietary datasets. Conclusions: ML algorithms are effective for detecting AF from ECGs. DL algorithms, particularly those based on convolutional neural networks (CNN), demonstrate superior performance in AF detection compared to TML algorithms. The integration of ML algorithms can help wearable devices diagnose AF earlier.
Effect of Exercise Modality on Heart Rate Variability in Adults: A Systematic Review and Network Meta-Analysis
Authors: Yang Faming , Ma Ying , Liang Shuangyan , Shi Yali , Wang Chen
Published: January 2024

Background: The purpose of this study was to use a network meta-analysis (NMA) to compare the effects of aerobic training (AT), resistance training (RT), combined training (CBT), and high-intensity interval training (HIIT) on adult heart rate variability (HRV). Methods: We searched PubMed, the Cochrane Library, Embase, the Web of Science, Wanfang Data, and the China National Knowledge Infrastructure to identify randomized controlled trials on the effects of exercise on HRV in adults. The search was conducted from the outset of these databases to April 2023. Two reviewers independently screened the retrieved articles, extracted raw data from the relevant studies, and assessed the possible risk of bias in the included studies. Results: The NMA showed that HIIT had the greatest effect on the low-frequency (LF) power/high-frequency (HF) power ratio, standard deviation of normal–normal intervals (SDNN), and root mean square of successive differences between adjacent normal-to-normal intervals (RMSSD) (surface under the cumulative ranking curve (SUCRA) = 99.75%, 98.7%, and 84.9%); CBT had the greatest effect on the LF power (SUCRA = 66.3%); RT had the greatest effect on the HF power (SUCRA = 72.5%). Conclusions: Our NMA and SUCRA ranking results suggest that in adults, HIIT is the most effective exercise modality in improving the SDNN, RMSSD, and LF/HF power ratio; RT for the HF power; CBT for the LF power. Any NMA conducted in the future must fully explore the effects of different exercise modalities on HRV in adult subgroups of different ages and genders. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=424054, identifier: CRD42023424054.
Impacts of Left Atrial Appendage Treatments on Mitral Valve Diseases during Surgical Ablations
Authors: Zhou Can , Zhao Yichen , Zhao Cheng , Ye Qing , Dong Jianzeng , Wang Jiangang
Published: January 2024

Background: Left atrial appendages (LAAs) play an important role in regulating left atrial function, and much evidence supports the possibility that changes in left atrial structure may cause or worsen mitral regurgitation. This study intended to investigate the outcomes of patients with mitral regurgitation who underwent left atrial appendage closure (resection or endocardial closure) during isolated surgical ablations. Methods: Patients with mild or moderate mitral regurgitation who received isolated surgical ablations for atrial fibrillation (AF) in our center from 2013 to 2022 were referred. During follow-up, each clinical visit was composed of medical interrogation, a 24 h Holter, and echocardiographic evaluation. Death, atrial fibrillation, worsening of mitral regurgitation, and stroke were evaluated as outcomes. Freedom from outcomes whose results were adjusted by inverse probability of treatment weighting for causal effects after acquiring propensity scores. Results: A total of 456 patients were enrolled in this study. During a median follow-up of 48 months, 30 deaths and 11 cases of stroke were observed. After adjustments, no significant differences in terms of death or stroke were observed among the three groups. Patients who underwent resection or endocardial closure during surgical ablations had a higher risk of mitral regurgitation worsening during follow-up (p < 0.05). During the whole follow-up, patients who underwent left atrial appendage interventions showed significantly larger left atrial and mitral annular diameters, as well as lower tethering height than those who had left atrial appendage preserved (all p < 0.05). Conclusions: Mitral regurgitation was more likely to get worse when patients with fundamental mitral diseases underwent LAA interventions during isolated surgical AF ablations. In the absence of LAA, the dilation of the left atrium and mitral annulus may ultimately lead to worsening of regurgitation.
Effectiveness and Safety of Different Patch Materials for Supravalvar Aortic Stenosis (Middle-Term Outcomes)
Authors: Lang Xinyue , Lv Lizhi , Zhang Simeng , Zhi Aihua , Wang Cheng , Wang Qiang
Published: January 2024

Background: To determine the effectiveness and safety of different patch materials in the treatment of pediatric patients with congenital supravalvular aortic stenosis (SVAS). Methods: 218 consecutive SVAS patients (age <14 years) who underwent surgery from Beijing Fuwai and Yunnan Fuwai hospital between 2002 and 2020 were included. Patients were divided into the pericardium patch group (133 (61.0%)), modified patch group (43 (19.7%)) and artificial patch group (42 (19.3%)). The primary safety endpoint was patch-related adverse complications (post-operation patch hemorrhage or aortic sinus aneurysm at 2-year follow-up). The primary effectiveness outcome was the re-operation or restenosis at 2-year follow-up. Multivariable cox regression was used to obtain the hazard ratio (HR). Results: The median age at operation was 43.5 months (IQR 24.0–73.0). Only three patients had patch-related adverse complications, and no difference existed among the three groups (p = 0.763). After a median follow-up of 24.0 months (IQR 6.0–48.0), patients with a pericardium patch had a lower re-operation or restenosis rate compared with the other two groups (pericardium patch vs modified patch, HR = 0.30, 95% CI 0.12–0.77; pericardium patch vs artificial patch, HR = 0.33, 95% CI 0.13–0.82), even in the main subgroup and sensitivity analysis. Conclusions: In pediatric patients, the safety of autologous pericardium patch is acceptable, along with lower rates of middle-term re-operation or restenosis. Clinical Trial Registration: http://www.chictr.org.cn, number: ChiCTR2300067851.
Serum 5′-Nucleotidase as a Novel Predictor of Adverse Clinical Outcomes after Percutaneous Coronary Intervention in Patients with Coronary Artery Disease
Authors: Aimaitijiang Mikereyi , Wu Ting-Ting , Zheng Ying-Ying , Hou Xian-Geng , Yang Haitao , Yang Yi , Xie Xiang
Published: January 2024

Background: The correlation between 5′-Nucleotidase (5′-NT) and the clinical outcomes in coronary artery disease (CAD) patients following percutaneous coronary intervention (PCI) is not clear. This study aims to clarify this relationship. Methods: The PRACTICE study enrolled 15,250 patients between December 2016 and October 2021. After filtering out those without 5′-NT data, a total of 6555 patients were analyzed with a median follow-up of 24 months. Based on the receiver operating characteristic (ROC) curve analysis, a 5′-NT level of 5.57 U/L was selected as the optimal cutoff value. All research samples were divided into high-value (≥5.57 U/L, n = 2346) and low-value groups (<5.57 U/L, n = 4209). Key clinical outcomes included all-cause death (ACD), cardiovascular death (CD), major adverse cardiovascular events (MACE), and major adverse cardiovascular and cerebrovascular events (MACCE). After separating patients into high and low value groups, multivariate Cox regression analysis was used to correct for potential confounding variables. Finally, risk ratios and their 95% confidence intervals (CIs) were calculated. Results: During the follow-up period, 129 instances of ACD were recorded—49 cases (1.2%) in the low-value group and 80 cases (3.4%) in the high-value group. Similarly, 102 CDs occurred, including 42 low-value group cases (1.0%) and 60 high-value group cases (2.6%). A total of 363 MACE occurred, including 198 low-value group cases (4.7%) and 165 high-value group cases (7%). A total of 397 cases of MACCE occurred, including 227 low-value group cases (5.4%) and 170 high-value group cases (7.2%). As serum 5′-NT increased, the incidence of ACD, CD, MACE and MACCE increased. After multivariate Cox regression, high 5′-NT levels were linked with a 1.63-fold increase in ACD risk (hazard ratio [HR] = 2.630, 95% CI: [1.770–3.908], p < 0.001) when compared to low 5′-NT patients. Similarly, the risk of CD, MACE, and MACCE increased by 1.298-fold (HR = 2.298, 95% CI: [1.477–3.573], p < 0.001), 41% (HR = 1.410, 95% CI: [1.124–1.768], p = 0.003) and 30.5% (HR = 1.305, 95% CI: [1.049–1.623], p = 0.017), respectively. Conclusions: high serum 5′-NT levels were independently correlated with adverse clinical outcomes in CAD patients following PCI, affirming its potential as a prognostic indicator.
Prognostic Capability of Clinical SYNTAX Score in Patients with Complex Coronary Artery Disease and Chronic Renal Insufficiency Undergoing Percutaneous Coronary Intervention
Authors: Li Mengyao , Liu Xu , Jiang Mao , Lei Yumeng , Li Zhongpei , Li Shicheng , Mao Ying , Cao Xufen , Yan Liqiu
Published: January 2024

Background: The SYNTAX score (SS) is useful for predicting clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). The clinical SYNTAX score (CSS), developed by combining clinical parameters with the SS, enhances the risk model’s ability to predict clinical outcomes. However, prior research has not yet evaluated the prognostic capacity of CSS in patients with complex coronary artery disease (CAD) and chronic renal insufficiency (CRI) who are undergoing PCI. We aimed to demonstrate the prognostic potential of CSS in assessing long-term adverse events in this high-risk patient cohort. Methods: A total of 962 patients with left main and/or three-vessel CAD and CRI were enrolled in the study spanning from January 2014 to September 2017. The CSS was calculated by multiplying the SS by the modified age, creatinine, and left ventricular ejection fraction (ACEF) score (age/ejection fraction + 1 for each 10 mL of creatinine clearance <60 mL/min per 1.73 m2). The patients were categorized into three groups based on their CSS values: low-CSS group (CSS <18.0, n = 321), mid-CSS group (18.0 ≤ CSS < 28.3, n = 317), and high-CSS group (CSS ≥28.3, n = 324) as per the tertiles of CSS. The primary endpoints were all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints included myocardial infarction (MI), unplanned revascularization, stroke, and major adverse cardiac and cerebrovascular events (MACCE). Results: At the median 3-year follow-up, the high-CSS group exhibited higher rates of ACM (19.4% vs. 6.6% vs. 3.6%, p < 0.001), CM (15.6% vs. 5.1% vs. 3.2%, p = 0.003), and MACCE (33.8% vs. 29.0% vs. 20.0%, p = 0.005) in comparison to the low and mid-CSS groups. Multivariable Cox regression analysis revealed that CSS was an independent predictor for all primary and secondary endpoints (p < 0 .05). Moreover, the C-statistics of CSS for ACM (0.666 vs. 0.597, p = 0.021) and CM (0.668 vs. 0.592, p = 0.039) were significantly higher than those of SS. Conclusions: The clinical SYNTAX score substantially enhanced the prediction of median 3-year ACM and CM in comparison with SS in complex CAD and CRI patients following PCI.
Global Insights into Chronic Obstructive Pulmonary Disease and Coronary Artery Disease: A Systematic Review and Meta-Analysis of 6,400,000 Patients
Authors: Zheng Yitian , Hu Zhenliang , Seery Samuel , Li Chen , Yang Jie , Wang Wenyao , Qi Yu , Shao Chunli , Fu Yi , Xiao Han , Tang Yi-Da
Published: January 2024

Background: The high prevalence of chronic obstructive pulmonary disease (COPD) in coronary artery disease (CAD) has been acknowledged over the past decade, although the cause/s remain uncertain due to differences in diagnoses. COPD has also become a leading CAD comorbidity, although again little is known about its interactions. This meta-analysis explored COPD prevalence in the global CAD population, as well as the influence of COPD on CAD. Methods: PubMed, Web of Science, Embase, and grey literature were searched until 26th November 2021. The prevalence of COPD was calculated, and data were grouped according to COPD diagnostic methods, interventions, region, economic status, etc. Outcomes including all-cause death, cardiac death, myocardial infarction, revascularization, stroke, heart failure, and respiratory failure were analyzed. This study was registered with PROSPERO (CRD No.42021293270). Results: There was an average prevalence of 14.2% for COPD in CAD patients (95% CI: 13.3–15.1), with diagnostics of COPD through spirometry, International Classification of the Diseases (ICD codes), and self-reported methods. Comorbid COPD–CAD patients were more likely to be smokers and suffer from cardiovascular and respiratory complications (all odds ratios [OR] >1). COPD–CAD has higher mortality (hazard ratio [HR] 2.81, 95% CI: 2.40–3.29), and myocardial infarction, stroke, and respiratory failure rates (all HR >1). Coronary artery bypass graft (CABG) reduces the need for revascularization (HR 0.43, 95% CI: 0.20–0.94) compared to percutaneous coronary intervention (PCI), without increasing mortality. Conclusions: The global prevalence of COPD is particularly high in CAD patients. COPD–CAD patients are more likely to encounter cardiovascular and respiratory complications and endure poorer outcomes. Limited evidence suggests that CABG may reduce the need for revascularization without increasing mortality, although further research is required to confirm these observations.
Specifics of establishment, management, and development of agriculture in special settlements in the North in the 1930s
Authors: Lobchenko Liudmila , Pankratova Maya , Yashin Anatoly
Published: January 2024

The article describes the reasons for large-scale use of labour of special settlement peasants in the North in the 1930s, focusing on the importance of special settlers for agricultural development in the North and the hardships of their labour and living conditions. In the circumstances of risky farming, the special settlers had created a developed farming and livestock base by the late 1930s, becoming almost self-sufficient. The article examines the issues of local economic management by special settlers and their role in the regional economic development.
Occurrences, distribution and sources of Pharmaceuticals and Personal Care Products (PPCPs) in the mangrove dominated estuaries in the central part of the Indian Sundarbans, a world heritage site.
Authors: GUPTA VANDANA , Vimalkumar Krishnamoorthi , Sanyal Prasun , Paul Madhusudan , Acharya Avanti , Bakshi Sneha , Majumdar Natasha
Published: January 2024

This study aimed to provide the baseline report on the occurrence of five emerging contaminants namely Phenols, Triclosan, NSAIDs, Phthalate and Parabens under pharmaceuticals and personal care products (PPCPs) in the surface water of Indian Sundarbans estuarine system. The emerging contaminants of PPCPs were investigated from the two estuaries in the central of Indian Sundarbans namely Thakuran and Matla covering entire stretch during post monsoon season using gas chromatography mass spectrometry (GC-MS). Among the different groups of PPCPs the most abundant found to be Phenolics with mean concentration ranging from 230 to 4586 ng/L following Triclosan with mean concentration for both Thakuran and Matla ranging from 96 to 1885 ng/L. The surface water concentration of remaining PPCPs ranged widely; like for NSAIDs (290 to 791 ng/L), Phthalates (39-302 ng/L) and Parabens (21-263 ng/L). Among the different Phenolics derivatives the highest concentration was found for octyl phenol ranging 282.2 to 17590.1 ng/L followed by Ketoprofen ranging 614.6 to 2333.7 ng/L and both derivatives observed to be high in the seafront side of Matla estuary. For the Phthalates derivatives high concentration witnessed in upstream of Thakuran and Matla i.e., for Di-2-ethylhexylphthalate ranging from 60.5 to 494.8 ng/L while for Parabens derivatives high concentration observed in downstream of Thakuran i.e., Ethyl paraben ranging from 23.7 to 598.7 ng/L. The correlation of water quality parameters with different PPCPs helps to elucidate the source as Phthalates are positively correlated with DIN and DIP which clarifies its typical anthropogenic source from catchment areas, run off from domestic sewage and effluents. Significant spatial variation observed for PPCPs indicating persistence and long residence of these xenobiotics in the mangrove dominated estuaries of Indian Sundarbans.
Development of metrics and indices for assessing national progress on climate risk, adaptation and dissonance based on observations, perceptions, and projections.
Authors: Serrano-Candela Fidel , Estrada Francisco , Raga Graciela , González Salazar Constantino
Published: January 2024

The 28th Conference of the Parties (COP28) included the first Global Stocktake (GST) as part of the implementation of the Paris Agreement. GST is a five-yearly assessment of the state and advancements in global climate action and aims to help national governments keep track of their climate ambitions and implementation progress. This paper contributes to the discussion through the analysis of harmonized country level datasets of metrics and indicators relevant for loss and damage analysis, survey information about people’s perceptions on climate change, projections of economic damages due to climate change. Indices are constructed to understand the association of the objective metrics of risk and vulnerability and the subjective perceptions of people in different countries. The analysis allows us to evaluate differences in vulnerability and countries where the dissonance between perceived and estimated climate change risks are larger and institutional strength and socioeconomic development are lagging. Combining the proposed indices, countries are ranked in terms of their current and future climate risk. An online tool is provided to visualize and access the results presented in this paper.
Reliability for multilevel data: A correlation approach
Authors: Lin Tzu-Yao , tuerlinckx francis , Vanbelle Sophie
Published: January 2024

Studying the reliability of a measurement instrument is essential. Despite therecognition of the importance of reliability in psychology and medicine and the variousreliability coefficients that have been proposed, research on reliability for nested or multilevel data, ubiquitously in observational studies, remains limited. Two recent papers (Schönbrodt et al., 2022; ten Hove et al., 2022) address how to quantify reliability in multilevel settings based on generalizability theory. Specifically, ten Hove et al. (2022) defined between-cluster and within-cluster interrater intraclass correlation coefficients for multilevel designs where persons or raters are nested within clusters. Schönbrodt et al. (2022) also defined reliability coefficients at between-cluster and within-cluster (i.e., between-person) levels for designs where persons nested in couples are assessed numerous times daily over a number of days. Nevertheless, when applied to a common design, both approaches give inconsistent results regarding their definition of cluster-level reliability. In this paper, we propose an alternative approach to defining reliability coefficients for multilevel data that are based on calculating the expected correlation between repeated measurements. We will compare our approach with that of Schönbrodt et al. (2022) and ten Hove et al. (2022) and explain the differences between the three approaches in a number of common nested data structures: (1) raters crossed with both persons and clusters, but persons are nested within clusters, (2) raters nested within both persons and clusters, and (3) persons nested in clusters and crossed with raters and days.
Intelligence Is/Is Not Neural Latency: A Comment on Schubert et al. (2023)
Authors: Lasker Jordan
Published: January 2024

As the name implies, general intelligence is general. Any two sufficiently large and diverse cognitive test batteries will measure the same g factor. Recent results also suggest that the g factor can be measured from neural latencies. Schubert et al. (2023) found that their best-fitting models showed a correlation that was indistinguishable from identity between psychometric g and a g factor based on event-related potentials. The finding that g can be measured from neural latencies extends the realm of the positive manifold beyond psychometric tests and into measurement via observation of the brain itself.