bluuebunny/crossref_metadata_2025 huggingface dataset:
КІБЕРЗАГРОЗИ ФІНАНСОВОГО СЕКТОРА В УМОВАХ ВІЙНИ
Authors: Гончаренко Ірина
Published: June 2023

У глобальному секторі кібербезпеки дві основні сфери, які постійно зазнають нападів – фінансова та державна. Триваюча цифрова трансформація фінансового сектору та посилення залежності від хмарних технологій після пандемії спричинили експоненціальне зростання площі атак у цьому секторі, піддаючи організації зростанню кіберзагроз. Атаки включають крадіжку конфіденційних даних клієнтів, шахрайство, фішинг, розповсюдження шкідливих програм, атаки на мережеву інфраструктуру та багато іншого. У статті досліджено сучасний стан виявлення кіберзлочинів у фінансовому секторі та втрати від кібератак на бізнес та громадян. Поточні економічні потрясіння також призвели до збільшення кількості зловмисників, які прагнуть викрасти конфіденційну інформацію та продати її на чорному ринку або вчинити шахрайство та отримати доступ до коштів облікового запису. Разом з тим, необхідним є створення кібербезпечного середовища, дотримання кибергігієни. Детекція та реагування на кібератаки: за допомогою системи моніторингу, виявлення та відстеження вразливостей, погроз та вимагань від користувачів стосовно зміни паролів. Необхідним є застосування передових технологій у межах захисту мереж, шифрування даних та ідентифікації користувачів, яких можна включити в систему вторинної ідентифікації особливо в умовах війни як триває в Україні.
Pénfigo IgA, reporte de un caso con diagnóstico y tratamiento difíciles
Authors: Barrientos Adriana , Jimenez Segura Ana Maria , Camacho Chaljub Francisco Miguel
Published: June 2023

Introducción: el pénfigo IgA es una enfermedad ampollosa autoinmune que se caracteriza por la presencia de lesiones pustulosas y ampollosas asociadas a dolor y prurito. Si bien, existen dos tipos principales: la dermatosis IgA neutrofílica intraepidérmica y la dermatos is pustulosa subcórnea, el amplio espectro en la presentación clínica y la superposición de los hallazgos con otras enfermedades ampollosas, hace difícil el enfoque diagnóstico y el tratamiento. Caso clínico: en el presente reporte de caso se describe a una mujer de 50 años de edad con una presentación atípica de enfermedad ampollosa la cual fue clasificada finalmente como pénfigo IgA con características de superposición, acorde a los hallazgos clínicos y los resultados de la inmunofluorescencia directa. Conclusiones: el pénfigo IgA actualmente es considerado un espectro de enfermedades ampollosas en el cual puede existir superposición de sus características con implicaciones terapéuticas y en el pronóstico que deben ser tenidas en cuenta.
Inmunopatología del Glioblastoma Multiforme y su importancia en el ámbito clínico
Authors: Torres Rodríguez María Paula , Murcia Garcia Kimberly Andrea , Cruz Baquero Claudia Andrea , Infante Cruz Alejandra del Pilar
Published: June 2023

Introducción: el glioblastoma multiforme es un tumor cerebral primario maligno. Su diagnóstico actualmente se basa en la presentación clínica del paciente y en estudios de imagenología, con un promedio de supervivencia inferior a 18 meses. Con base en dicho diagnóstico, se vuelve indispensable establecer tratamientos alternativos y personalizados, utilizando como herramienta la información obtenida al evaluar el microambiente tumoral, el cual a su vez determina el puntaje dado por el inmunoscore. Objetivo: demostrar la importancia de conocer el microambiente tumoral del glioblastoma multiforme como herramienta para su aplicación en el ámbito clínico. Métodos: se realizó una búsqueda en las bases de datos PubMed, Google Scholar, Oxford Academic, Scielo, Elsevier y Nature Portfolio, que incluyó artículos publicados en los últimos veinte años entre el 16 de octubre del 2001 y el 14 de julio del 2021. Resultados: la base de datos otorgó información actual sobre la inmunopatología del glioblastoma multiforme, su importancia en el ámbito clínico y sobre cómo herramientas como el inmunoscore pueden impulsar el uso de tratamientos personalizados que mejoren el pronóstico en el paciente con dicha enfermedad. Se evidenció que existen pocos grupos trabajando en esta área. Conclusión: realizar estudios al comportamiento celular inmunológico en el microambiente tumoral para dar puntajes acordes al inmunoscore en cada paciente puede presentar alternativas de tratamiento personalizado, mejorando la calidad de vida y la vida media después del diagnóstico.
Importancia y desafío de la investigación científica médica en el pregrado
Authors: Gradis Olman , González Carlos Alberto , Puerto Sanabria Carlos Roberto , Maradiaga Montoya Ramón Yefrin , Martínez Fernández Brayan Julián , Pinel Guzmán Esther
Published: June 2023

La investigación científica a nivel de pregrado es un pilar importante en la formación profesionales de la medicina. En la actualidad es de mucha preocupación el desinterés por parte de los estudiantes, de docentes y de instituciones en esta área, ya sea por ausencia de maestros guía, desmotivación, así como infravaloración del método científico, el escaso espacio curricular asignado para estos proyectos, la sobrecarga académica u otras causas. Esta reflexión busca describir la importancia de la investigación científica a nivel de pregrado de medicina como parte de la formación profesional y proporcionar una serie de posibles opciones para resolver el problema.
 
Se ha demostrado que sólo un pequeño porcentaje de los estudiantes muestran interés por la investigación y un grupo más pequeño logra publicar algún trabajo en revistas científicas. La investigación científica en el pregrado de medicina es un pilar en la formación de profesionales que les permite brindar una mejor atención médica basada en evidencias, así como una oportunidad para reforzar lo aprendido en sus aulas. Además, trae varios beneficios del pensamiento crítico, la escritura, la reputación académica y científica.
“Severidad y mortalidad de enfermedad por SARS-COV-2 en pacientes con Asma o EPOC en un hospital de la ciudad de Cartagena-Colombia, en el año 2020”
Authors: Ariza Escobar Wilhen , Aguilar Salcedo Nataly , Meza Ruiz William , Ariza García Amaury
Published: June 2023

Introducción: La enfermedad causada por SARS-CoV-2, declarada como pandemia por la OMS en marzo de 2020 cuenta con más de 300 millones de casos confirmados en más de 46 países en el año 2022 y más de 5 millones de casos en Colombia. Se ha evidenciado que las tasas más altas de letalidad se encuentran en aquellos pacientes con comorbilidades, entre las cuales, la OMS ha destacado a las enfermedades crónicas respiratorias como asma y EPOC como grupo de alto riesgo para el desarrollo de enfermedad severa. Sin embargo, se cuestiona si estas en realidad representan un factor de riesgo para el desarrollo de enfermedad severa y aumento de la mortalidad de la COVID-19, a la fecha los resultados de los estudios han sido contradictorios y los realizados hasta el momento muestran una baja prevalencia de asma y EPOC en los casos confirmados de COVID-19. Objetivo: establecer la severidad y mortalidad de enfermedad por SARS-CoV-2 en pacientes con asma o EPOC y población sin estos antecedentes. Métodos: Estudio retrospectivo, descriptivo de corte transversal, se tomaron historias clínicas de todos los casos confirmados de infección por SARS-CoV-2, mediante RT-PCR de hisopado nasofaríngeo, en un período de 9 meses, los cuales fueron clasificados en tres grupos: con antecedentes de asma, antecedentes de EPOC y quienes no contaban con dichos antecedentes. Resultados: Se incluyeron 686 pacientes, se observó una mortalidad del 16.3% (n=110). La mediana de edad en la población general fue de 45.5 años. El 4.9% y el 4.2% de la población reportó asma y EPOC como antecedente patológico, respectivamente. Tener un diagnóstico de EPOC, la edad y el antecedente de diabetes mellitus se asociaron con aumento de la mortalidad. Para la severidad de la enfermedad se encontró que la edad, el sexo masculino y el diagnóstico de diabetes mellitus, se asociaron de forma independiente con aumento del riesgo de presentar enfermedad severa por COVID-19. Para asma no se encontró asociación con desenlaces mayores como aumento de la severidad ni la mortalidad de la COVID-19. Conclusión: En esta serie de casos se encontró que tener el antecedente de EPOC representa un factor de riesgo para aumento de la mortalidad por COVID-19 pero no para severidad, mientras que el asma o el uso de corticoides como antecedente no se asociaron a ningún resultado clínico.
Perspectiva actual en manejo de Arritmias en Cardiomiopatía Chagásica
Authors: Arellano Alyi Alejandro , Castilla Sofia Marina , Ortiz Eduer , Lozano Tatiana
Published: June 2023

Introducción: la enfermedad de Chagas es un problema de salud pública en América Latina y las arritmias ventriculares son las complicaciones más frecuentes, es por esto por lo que se hace crucial conocer su abordaje terapéutico. La enfermedad de Chagas representa un impacto mayor a la salud debido a que suele presentarse en poblaciones con dificultades al acceso a los servicios de salud. La aparición de arritmias es una situación común en estos pacientes con afectación cardiaca. Objetivo: elaborar una revisión narrativa sobre los diferentes manejos terapéuticos utilizados actualmente en los pacientes con cardiomiopatía Chagásica que padecen arritmias ventriculares. Métodos: se realizó una revisión general de la literatura mediante la búsqueda de artículos en varias bases de datos. Se encontró en la búsqueda inicial 14.400 artículos y finalmente se incluyeron 17 en la revisión. Resultados: la cardiomiopatía Chagásica es la complicación más frecuente de la infección por el T. Cruzi donde una de sus presentaciones clínicas iniciales es la aparición de arritmias y la explicación más aceptada actualmente sobre su fisiopatología la divide en cuatro tipos de alteraciones: microvascular, disautonomía, mecanismo inmunológico por autoanticuerpos y daño miocárdico directamente relacionado con la persistencia del parásito en el tejido. Conclusión: el tratamiento médico farmacológico y no farmacológico ha dado resultados positivos, pero todavía hace falta evidencia sobre las repercusiones a largo plazo.
On control of spacecraft orientation to the ground data acquisition station
Authors: Ivanova G.A. , Khoroshilov V.S.
Published: June 2023

The article dwells on the spacecraft attitude control to point the onboard antenna to the ground data acquisition station during the communication session. Antenna is fixed relative to the spacecraft body. Pur-pose of the antenna is to receive the flight task aboard the spacecraft and to downlink the telemetry infor-mation. When orbiting, the spacecraft position relative to the ground data acquisition station changes contin-uously. It is due to the diurnal rotation of the Earth, spacecraft orbital motion and angular motion of the spacecraft relative to the center of mass under the impact of the disturbing and control moments. To tilt the spacecraft uses reaction wheels, installed in axes of coordinate system coupled with spacecraft center of mass. Electromagnets are used to unload the reaction wheels. The reaction wheels control law is suggested, which tilts the spacecraft to point the antenna to the ground data acquisition station. Mathematical model of the spacecraft dynamics relative to center of mass is given, using the suggested reaction wheels control law. The following external disturbing moments, acting on the spacecraft in flight, are taken into consideration: gravitational, magnetic, aerodynamic moments and solar radiation moment of forces. Dipole model of the magnetic field of the Earth is used to calculate the magnetic moments. Software was developed and space-craft dynamics was simulated on the personal computer with the specified initial data. Simulation initial con-ditions correspond to the attitude control mode of the spacecraft relative to the orbital coordinate system with the specified accuracy. Simulation results verify the applicability of the suggested reaction wheel control law. Key words: electrical axis of the antenna, mathematical model, coordinate system, transformation matrix, vector.
ANALYSIS OF THE HEALTHCARE MANAGEMENT SYSTEM IN UKRAINE
Authors: Yelisieieva O. K. O. K. , Khmelik V. I.
Published: June 2023

Objective. The objective of the present article is to analyze the health care system in Ukraine at different levels, the development of medical care in Ukraine, to determine the purpose and objectives of primary health care on the basis of family medicine and the classification of medical services.

Methods. The research methods are historical-logical and system-structural approaches to the analysis of the medical field of Ukraine. Modern methods of analysis, method of expert assessments, comparative analysis, etc. are used. The information base of the research is scientific works of domestic and foreign scientists, Laws of Ukraine, resolutions of the Cabinet of Ministers of Ukraine, regulations and statistical materials of the State Statistics Service of Ukraine, World Data Bank, Eurostat and the Center for Medical Statistics of Ukraine, research and analytical materials, Internet resource.

Results. the current state of the primary health care system on the basis of family medicine in Ukraine and Europe has been studied. The development of the health care system from social medicine to the current health care system has been studied. The structure of the Ministry of Health has been studied, and the responsibility of the sectors for the development of modern medicine in Ukraine has been studied. The hierarchy of the health care system was studied, it was found that it includes national, regional and local levels. The purpose and objectives of medical care are identified, namely - to ensure a guaranteed amount of affordable, timely, quality and effective primary care to the patient, improve public health, preserve, restore and strengthen the health of the population. The classification of medical services is determined.

The basic principles of family medicine are revealed, which include - family approach, patient orientation, preventive orientation, accessibility, equality and non-discrimination, multidisciplinary, continuity, longevity and coordination. The assessment of medical care of the population in the countries of Europe and Ukraine is carried out. To do this, we analyzed the cost of health care. International experience shows that the optimal level of health care spending is 8-10% of GDP and data from EU member states confirm this. In Ukraine, per capita health expenditures have been steadily increasing during 2010-2016, with an average of 3.8% of GDP in recent years.
THE PROJECT APPROACH OF PERSONNEL MANAGEMENT OF THE ORGANIZATION
Authors: Ivanova N. S. , Lyzhnyk Yu. B.
Published: June 2023

Objective. The objective of the present article is a theoretical study of the application of the project approach to personnel management of the organization.

Methods. To achieve the objective, methods of theoretical generalization, analysis and synthesis, logical generalization, analogies, comparative comparison, formal and substantive modeling were used.

Results. As a result of the study, it was determined that the project approach is an approach to management that operates with a significant amount of tools, technologies and knowledge, with the use of which project management and project management are carried out and the best results of project planning and implementation are achieved. The transition from traditional management to project management requires certain conditions: clearly defined project goals and results, defined deadlines and resources, high professionalism of the project manager (project manager), etc. The transition to project management within existing management systems is possible, despite the characteristic temporality. The project approach involves the presentation of tasks defined to achieve the strategic goals of the organization (SMART goals) as certain projects. In this case, the key function of personnel management is transferred to the project manager. It has been proven that the project manager is a central figure in project management, whose role is to form connections and direct all project participants to the effective completion of the project. The application of a project approach to personnel management and the formation of project teams will strengthen the alignment of the goals of employees and the company. As a result of the conducted research, it was determined that the manager in project management is a certain key to the success of the organization, and therefore the question of the competence of the project manager causes many discussions. The results allow us to state that the importance of the need for soft skills is more noticeable than the need for hard skills, precisely because of the importance of the presence of interpersonal competencies of the project manager.
EU FRAMEWORK PROGRAMS FOR RESEARCH AND TECHNOLOGY DEVELOPMENT AS THE MAIN FINANCIAL TOOL OF EU INNOVATION POLICY
Authors: Bocharova Yu. H. , Chernega O. B. , Kozhuhova T. V. , Ishchenko O.V.
Published: June 2023

Objective. The objective of the article is the analysis of the EU framework programs for the development of research and technology as the main financial tool of EU innovation policy.

Methods. The following methods and techniques of cognition are used in the research process: theoretical generalization and comparison, analysis and synthesis, induction and deduction, grouping.

Results. According to the results of the study, it is substantiated that innovation has always been considered by the EU as a dominant determinant of socio-economic development and ensuring competitiveness. EU innovation policy has been closely linked to scientific, technical, industrial, environmental, regional and other EU policies. It is determined that the main goals of the EU innovation policy are: open innovation, open science and openness to the world. It is determined that since 1984 - until now: 8 framework programs have been implemented, the implementation of the 9th program is planned for 2021-2027; Framework programs are constantly evolving, which is reflected in the change: the duration of the framework programs, their objectives, thematic areas, horizontal activities, budget, etc. It is argued that the most ambitious of the EU Framework Programs is the 9th Framework Program, with a total budget of € 96899 million, divided between 4 horizontal programs (Widening Participation & Strengthening The European Research Area, Innovative Europe, Excellent Science, Global Challenges And European Industrial Competitiveness) and 15 components (Widening participation and spreading excellence, reforming and enhancing the European R&I System, European Innovation Council (EIC), European innovation ecosystems, European Institute of Innovation and Technology (EIT), The European Research Council (ERC), Marie Skłodowska-Curie Actions (MSCA), Research infrastructures, Health, Culture, creativity and inclusive society, Civil Security for Society, Digital, Industry and Space, Climate, Energy and Mobility, Food, Bioeconomy, Natural Resources, Agriculture and Environment, Non-nuclear direct actions of the Joint Research Centre (JRC)).
Perancangan Sistem Monitoring Lampu Berbasis Internet of Things
Authors: Sangkar M , Basri  , Emil A.
Published: June 2023

Lampu merupakan komponen penting dalam kehidupan sehari-hari, sehingga dibutuhkan sebuah efektivitas dalam mengontrol dan monitoring lampu. Pada saat kontrol dan memonitoring lampu ini bekerja berdasarkan pusat pengontrol yang dalam sistem ini adalah smartphone berbasis android dengan memanfaatkan jaringan hospot atau wifi. Lampu menyala jika pada aplikasi kendali lampu di smartphone android, lampu dinyalakan dan lampu akan mati jika pada kendali lampu smarphone android dimatikan. Pada saat ini terdapat NodeMCU yang berfungsi sebagai penghubung deteksi lampu menyala, sehingga user pada smartphone android dapat mengetahui jika saat dinyalakan lampu dan menyala.
Management and Outcome of Intracranial Dural Arteriovenous Fistulas That Have Caused a Hemorrhage in the Posterior Fossa : A Clinical Study
Authors: Akdag Rıfat , Soylu Uğur , Dağlıoğlu Ergün , Akmangit İlkay , Açık Vedat , Belen Ahmet Deniz
Published: June 2023

Objective : We evaluated the diagnosis, treatment, and long-term results of patients with dural arteriovenous fistula (dAVF), which is a very rare cause of posterior fossa hemorrhage.Methods : This study included 15 patients who underwent endovascular, surgical, combined, or Gamma Knife treatments between 2012 and 2020. Demographics and clinical features, angiographic features, treatment modalities, and outcomes were analyzed.Results : The mean age of the patients was 40±17 years (range, 17–68), and 68% were men (11/15). Seven of the patients (46.6%) were in the age group of 50 years and older. While the mean Glasgow coma scale was 11.5±3.9 (range, 4–15), 46.3% presented with headache and 53.7% had stupor/coma. Four patients (26.6%) had only cerebellar hematoma and headache. All dAVFs had cortical venous drainage. In 11 patients (73.3%), the fistula was located in the tentorium and was the most common localization. Three patients (20%) had transverse and sigmoid sinus localizations, while one patient (6.7%) had dAVF located in the foramen magnum. Eighteen sessions were performed on the patients during endovascular treatment. Sixteen sessions (88.8%) were performed with the transarterial (TA) route, one session (5.5%) with the transvenous (TV) route, and one session (5.5%) with the TA+TV route. Surgery was performed in two patients (14.2%). One patient (7.1%) passed away. While there were nine patients (64.2%) with a Rankin score between 0 and 2, the total closure rate was 69.2% in the first year of control angiograms.Conclusion : In the differential diagnosis of posterior fossa hemorrhages, the differential diagnosis of dAVFs, which is a very rare entity, should be considered, even in the middle and elderly age groups, in patients presenting with good clinical status and pure hematoma. The treatment of such patients can be done safely and effectively in a multidisciplinary manner with a good understanding of pathological vascular anatomy and appropriate endovascular treatment approaches.
TITIK TEMU KONSEP PENDIDIKAN KI HADJAR DEWANTARA DENGAN KURIKULUM MERDEKA BELAJAR (STUDI KOMPARATIF)
Authors: Angga Febriyatko  , Cut Dian Rahmawati  , Khusnul Fatimah  , Igajadwar Batalemba
Published: June 2023

The Free Learning Curriculum Policy is a learning program with the concept of independent education. This is in line with the thinking of the pioneer of our nation's education, namely Ki Hadjar Dewantara who directed education as an effort to liberate humans, both outwardly and mentally. The concept of independence can be seen in the freedom of educators to control learning and the freedom of students to take advantage of opportunities in learning widely and flexibly. This study aims to analyze the concept of Ki Hadjar Dewantara education with the Merdeka Belajar Curriculum that has been implemented today in Indonesia. The method in this research is a qualitative descriptive method with a literature study approach. Data in the form of information from several libraries. Data collection techniques by studying documents in books, journals, and others related to the educational concept of Ki Hadjar Dewantara and the Merdeka Learning Curriculum. The analysis technique used is data analysis using the Miles and Huberman interactive model. The findings of this study are that there is a relevant meeting point between the educational concept of Ki Hadjar Dewantara and the Independent Learning Curriculum in learning systems and methods, the position of students and educational techniques applied to create an independent education and Pancasila Student Profile character.
NARRATIVE REVIEW: COST-EFFECTIVENESS ANALYSIS OF THE USE OF ORAL ANTIDIABETIC DRUGS BIGUANIDE AND SULFONYLUREA GROUP IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Ivana Kezia , Pradana Dhigna Luthfiyani Citra , Aprilia Citra Ayu
Published: June 2023

Diabetes Mellitus requires long-term management at a considerable cost. Therefore, a cost-Effectiveness analysis was used to assess several health interventions. Biguanide and Sulfonylurea provided the best results at the cheapest cost in this study. This study aims to gain a supporting theoretical foundation regarding the cost-effectiveness of using oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. The method used in this study is a Narrative Review using literature that discusses the cost-effectiveness of oral antidiabetic drugs biguanide and sulfonylureas in patients with type 2 diabetes mellitus. Based on the results of this study, the age range of the occurrence of Type 2 Diabetes Mellitus is 45-65 years, with more percentage of male patients than women and a common complication is hypertension. In this study, the use of the biguanide drug (Metformin) was shown to provide a significant reduction in blood sugar levels at a reasonably low cost. The ICER results showed that combination drugs increased additional costs, but their use was more effective in healing and improving patients' quality of life. In conclusion to this study, the use of biguanide and sulfonylurea groups proved cost-effective compared to other antidiabetic drugs.
ANTIBACTERIAL ACTIVITY TEST OF BAY LEAF EXTRACTS (SYZYGIUM POLYANTHUM (WIGHT) WALP.) AGAINST STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI: SYSTEMATIC LITERATURE REVIEW
Authors: Sapoetri Gladys Imanda , Revina Rika , Muti Annisa Farida
Published: June 2023

Antibiotic resistance is a global health problem that has severe implications for morbidity, mortality, and health costs. Based on the Antimicrobial Resistant in Indonesia (AMRIN-Study), it was reported that there were bacteria that were resistant to antibiotics, including Escherichia coli, which is resistant to ampicillin trimethoprim-sulfamethoxazole and ciprofloxacin; and Staphylococcus aureus which is resistant to oxacillin, vancomycin, clindamycin, and levofloxacin. In Indonesia, Syzygium polyanthum (Wight) Walp. Bay leaf is one of the plants that is often used as spices. Its bay leaf contains secondary metabolites that have an antibacterial function. This study analyzed the antibacterial activities of bay leaf extract against Staphylococcus aureus and Escherichia coli. This research used a systematic literature review with a literature search strategy using Google Scholar and PubMed. The literature discusses bay leaf extract, Staphylococcus aureus, Escherichia coli, and antibacterial activity. From this study, 14 research articles described the antibacterial activity of bay leaf extract by inhibiting the growth of Staphylococcus aureus and Escherichia coli in the medium, strong, and very strong categories. Bay leaf extract can inhibit the growth of Staphylococcus aureus and Escherichia coli because it contains phytochemical compounds with antibacterial properties, including alkaloids, flavonoids, steroids/ triterpenoids, saponins, tannins, phenols, essential oils, and carbohydrate.
Sensitive aerial hearing within a noisy nesting soundscape in a deep-diving seabird, the common murre Uria aalge
Authors: Smith AB , Fischer-McMorrow I , Kolbeinsson Y , Rasmussen M , Shero MR , McElwaine JN , Jones OR , Mooney TA
Published: June 2023

Diving seabirds face a combination of sound exposure in marine and terrestrial environments due to increasing human encroachment on coastal ecosystems. Yet the sound-sensitivity and sensory ecology of this threatened group of animals is largely unknown, complicating effective management and conservation. Here, we characterize aspects of the acoustic ecology of the common murre Uria aalge, one of the deepest diving alcid seabirds. Electrophysiological aerial hearing thresholds were measured for 12 wild, nesting individuals and compared to conspecific vocalizations and short-term aerial soundscape dynamics of their cliff nesting habitat. Auditory responses were measured from 0.5 to 6 kHz, with a lowest mean threshold of 30 dB at 2 kHz and generally sensitive hearing from 1 to 3.5 kHz. The short-term murre nesting soundscape contained biotic sounds from con- and heterospecific avifauna; broadband sounds levels of 56-69 dB re: 20 µPa rms (0.1-10 kHz) were associated with both diel and tidal-cycle factors. Five murre vocalization types showed dominant spectral emphasis at or below the region of best hearing. Common murre hearing appears to be less sensitive than a related alcid, the Atlantic puffin Fratercula arctica, but more sensitive than other non-alcid diving birds described to date, suggesting that adaptations for deep diving have not caused a loss of the species’ hearing ability above water. Overall, frequencies of common murre hearing and vocalization overlap with many anthropogenic noise sources, indicating that the species is susceptible to disturbance from a range of noise types.
Perancangan Video Informasi “Lengger Lanang” dengan Teknik Animasi Motion Graphic untuk Kalangan Remaja Usia 17-22 Tahun
Authors: Nadya Nadya , Nyta Lia
Published: June 2023

AbstrakLengger Lanang merupakan seni tari yang berasal dari Kabupaten Banyumas dan sering digunakan untuk kesenian sakral karena dianggap masyarakat setempat memiliki nilai religi dan spiritual sebagai representasi rasa syukur kepada Dewi Sri atas kesuburan tanah dan kelimpahan panen. Seiring perkembangan waktu, tarian Lengger Lanang semakin mendapatkan stigma negatif dari masyarakat setempat hal ini dikarenakan kurangnya pengetahuan masyarakat khususnya remaja akan nilai seni dan budaya daerah dalam hal ini tarian Lengger Lanang dan juga kurangnya media informasi mengenai tarian Lengger Lanang. Dari hal tersebut, dibutuhkan media informasi yang dapat membuka stigma negatif masyarakat terutama kalangan remaja usia 17-22 tahun sehingga kesenian ini dapat dihargai dan dilestarikan. Metodologi penelitian yang digunakan adalah dengan pendekatan kualitatif deskriptif serta menggunakan teknik pengumpulan data seperti kepustakaan, wawancara, observasi dan survei dengan menitikberatkan pada teori ikonografi sebagai bentuk dan penggambaran visualisasi dengan narasi cerita serta teori animasi motion graphic sebagai teknik pengolahan media animasi.  Hasilnya perancangan animasi motion graphic tari Lengger Lanang dapat dijadikan sebagai media informasi sekaligus menjadi materi edukasi yang memberikan pandangan positif terhadap tari Lengger Lanang sebagai salah satu tarian yang perlu di lestarikan dan nilai-nilai positif yang ada di dalamnya. Kata Kunci: Lengger Lanang, motion graphic, video informasi, tari AbstractLengger Lanang is a dance originating from Banyumas Regency. It is often used for sacred arts because the local community considers it to have religious and spiritual values as a representation of gratitude to Dewi Sri for the fertility of the land and an abundance of harvests. Over time, the Lengger Lanang dance has increasingly received a negative stigma from the local community, and this is due to the lack of knowledge of the community, especially teenagers, about regional artistic and cultural values; in this case, the Lengger Lanang dance, and also the lack of information media about the Lengger Lanang dance. From this, information media is needed to open up the negative stigma of society, especially among youth aged 17-22 years, so that this art can be appreciated and preserved. The research methodology used is a descriptive qualitative approach. It uses data collection techniques such as literature, interviews, observation, and surveys, emphasizing iconography theory as a form and depiction of visualization with story narration and motion graphic animation theory as an animation media processing technique. The result is that the motion graphic animation of the Lengger Lanang dance can be used as an information medium as well as educational material that gives a positive view of the Lengger Lanang dance as a dance that needs to be preserved and the positive values in it. Keywords: dance, information video, Lengger Lanang, motion graphic
Implementasi desain Smart Stick untuk anak tunanetra berbasis GPS terintegrasi dengan smartphone
Authors: Utomo Agus Priyo , Sucipto Adi , Ayu Wulandari Sholihah , Rosyady Ahmad Fahriyannur , Lazuardi Mochammad Enrique , Dyiono Dyiono
Published: June 2023

Dewasa ini, banyak anak yang memiliki kebutuhan khusus dalam hidupnya. Anak-anak berkebutuhan khusus membutuhkan bantuan teknologi untuk menemukan mereka jika mereka kehilangan kontak dengan keluarga mereka. Masalahnya jika tidak memiliki alat akan sulit untuk mengenali lokasi dimana mereka berada. Penelitian ini bertujuan untuk membuat smart stick (tongkat pintar) untuk anak tunanetra. Tongkat pintar ini memiliki banyak fitur dalam teknologi disini sensor ultrasonik dan sensor GPS (Global Positioning System).  Hasil luaran sensor ultrasonik dan sensor GPS diproses oleh arduino. Sensor ultrasonik dapat mendeteksi rintangan di sekitar dan memberikan peringatan berupa suara peringatan. Tongkat pintar ini juga dilengkapi dengan sistem keamanan di bagian dalam dan luar yang dilengkapi dengan alat pelacak dan notifikasi. Apabila tombol pada Tongkat ditekan maka GPS akan mengambil nilai koordinat dan mengirimkannya melalui SMS (Short Message System). Sistem keamanan ini bertujuan agar anak tunanetra merasa lebih aman saat menggunakan tongkat karena adanya alat pendeteksi rintangan dan alat pelacak. Tongkat pintar ini dilengkapi dengan huruf braille di tombol tekannya untuk memudahkan anak tunanetra memahami fungsi dari tombol pada smart stick. Hasil dari penelitian ini telah lolos uji, dengan terpenuhinya fitur-fitur yang direncanakan dalam pengujian. Tongkat pintar dapat digunakan oleh anak-anak tunanetra di lokasi mereka yang hilang.

ABSTRACTNowdays, there are many children who have special need in their life. The children who have special needs in sight need some help with technology. It will be very difficult to find them if they have lost contact with their family. The problem is difficult to recognize the location where they are. This research has the objective to make smart stick for blind children. This smart stick has many features in technologies. It has sensor ultrasonic sensor and GPS sensor. The Ultrasonic Sensor and GPS Sensor are processed by Arduino. The Ultrasonic sensor can detect the obstacles around and give warning in the form of a warning sound. This smart stick is also equipped with a security system on the inside and outside equipped with tracking devices and notifications. Beside that, If the button of the stick is pressed, the GPS will take the coordinate value and send it via SMS (Short Message System). This security system aims to make blind children feel safer when using the stick because of the obstacle detector and tracking device. This smart stick is equipped with braille word in their push button. The result from this research is success in testing. The smart stick can be used by blind children in their lost location.
Penggunaan metode string matching pada sistem informasi mahasiswa Polinema dengan chatbot
Authors: Ardiansyah Rizky , Marya Dianthy , Novianti Atik
Published: June 2023

Pelayanan kampus yang baik sangat penting untuk menunjang proses belajar mengajar di perguruan tinggi. Salah satu cara untuk meningkatkan pelayanan adalah dengan menggunakan chatbot. Chatbot dapat memberikan pelayanan yang cepat dan efisien kepada mahasiswa, serta membantu dalam mendapatkan informasi yang dibutuhkan. Chatbot dapat memberikan pelayanan yang efektif dan efisien dalam menyediakan informasi dan melakukan transaksi. Penggunaan chatbot juga mengurangi beban kerja petugas administrasi dan memungkinkan mereka untuk fokus pada tugas yang lebih kompleks. Meskipun demikian, perlu perbaikan dalam aspek keamanan data dan privasi. Penelitian ini bertujuan untuk menguji aplikasi chatbot pelayanan administrasi dengan menggunakan metode string matching. Pengujian dilakukan melalui beberapa tahap, termasuk pengujian fungsi, interaksi, kompatibilitas, keamanan, dan performa chatbot. Hasil pengujian menunjukkan bahwa chatbot memiliki tingkat akurasi sebesar 90% dengan metode string matching. Mayoritas mahasiswa merasa puas dengan kecepatan dan akurasi respon chatbot. Selain itu, aplikasi ini juga dianggap mudah digunakan oleh mahasiswa.

ABSTRACTCampus services are crucial for supporting the teaching and learning process in higher education institutions. One effective approach to enhance these services is through the implementation of chatbots. Chatbots provide prompt and efficient assistance to students, enabling them to easily access the necessary information. They offer an efficient and effective means of delivering services by providing accurate information and facilitating transactions. Furthermore, the utilization of chatbots alleviates the burden on administrative staff, allowing them to focus on more complex tasks. However, it is important to address and improve data security and privacy aspects. This research aims to evaluate an administrative service chatbot using the string matching method. The evaluation process encompasses assessing the chatbot's functionality, interaction capabilities, compatibility, security measures, and overall performance. The results demonstrate an impressive 90% accuracy rate achieved through the implementation of the string matching method. The majority of students’s express satisfaction with the chatbot's promptness and accuracy in providing responses. Additionally, the application is highly regarded for its user-friendly interface, as reported by the students.
Development potential of extracellular matrix hydrogels as hemostatic materials
Authors: Cai Dan , Weng Wei
Published: June 2023

The entry of subcutaneous extracellular matrix proteins into the circulation is a key step in hemostasis initiation after vascular injury. However, in cases of severe trauma, extracellular matrix proteins are unable to cover the wound, making it difficult to effectively initiate hemostasis and resulting in a series of bleeding events. Acellular-treated extracellular matrix (ECM) hydrogels are widely used in regenerative medicine and can effectively promote tissue repair due to their high mimic nature and excellent biocompatibility. ECM hydrogels contain high concentrations of extracellular matrix proteins, including collagen, fibronectin, and laminin, which can simulate subcutaneous extracellular matrix components and participate in the hemostatic process. Therefore, it has unique advantages as a hemostatic material. This paper first reviewed the preparation, composition and structure of extracellular hydrogels, as well as their mechanical properties and safety, and then analyzed the hemostatic mechanism of the hydrogels to provide a reference for the application and research, and development of ECM hydrogels in the field of hemostasis.
Long non-coding RNAs modulate tumor microenvironment to promote metastasis: novel avenue for therapeutic intervention
Authors: Baba Sana Khurshid , Baba Sadaf Khursheed , Mir Rashid , Elfaki Imadeldin , Algehainy Naseh , Ullah Mohammad Fahad , Barnawi Jameel , Altemani Faisal H. , Alanazi Mohammad , Mustafa Syed Khalid , Masoodi Tariq , Akil Ammira S. Alshabeeb , Bhat Ajaz A. , Macha Muzafar A.
Published: June 2023

Cancer is a devastating disease and the primary cause of morbidity and mortality worldwide, with cancer metastasis responsible for 90% of cancer-related deaths. Cancer metastasis is a multistep process characterized by spreading of cancer cells from the primary tumor and acquiring molecular and phenotypic changes that enable them to expand and colonize in distant organs. Despite recent advancements, the underlying molecular mechanism(s) of cancer metastasis is limited and requires further exploration. In addition to genetic alterations, epigenetic changes have been demonstrated to play an important role in the development of cancer metastasis. Long non-coding RNAs (lncRNAs) are considered one of the most critical epigenetic regulators. By regulating signaling pathways and acting as decoys, guides, and scaffolds, they modulate key molecules in every step of cancer metastasis such as dissemination of carcinoma cells, intravascular transit, and metastatic colonization. Gaining a good knowledge of the detailed molecular basis underlying lncRNAs regulating cancer metastasis may provide previously unknown therapeutic and diagnostic lncRNAs for patients with metastatic disease. In this review, we concentrate on the molecular mechanisms underlying lncRNAs in the regulation of cancer metastasis, the cross-talk with metabolic reprogramming, modulating cancer cell anoikis resistance, influencing metastatic microenvironment, and the interaction with pre-metastatic niche formation. In addition, we also discuss the clinical utility and therapeutic potential of lncRNAs for cancer treatment. Finally, we also represent areas for future research in this rapidly developing field.
Cervical cancer benefits from trabectedin combination with the β-blocker propranolol: in vitro and ex vivo evaluations in patient-derived organoids
Authors: Di Fonte Roberta , Strippoli Sabino , Garofoli Marianna , Cormio Gennaro , Serratì Simona , Loizzi Vera , Fasano Rossella , Arezzo Francesca , Volpicella Mariateresa , Derakhshani Afshin , Guida Michele , Porcelli Letizia , Azzariti Amalia
Published: June 2023

Background: Cervical cancer (CC) is characterized by genomic alterations in DNA repair genes, which could favor treatment with agents causing DNA double-strand breaks (DSBs), such as trabectedin. Hence, we evaluated the capability of trabectedin to inhibit CC viability and used ovarian cancer (OC) models as a reference. Since chronic stress may promote gynecological cancer and may hinder the efficacy of therapy, we investigated the potential of targeting β-adrenergic receptors with propranolol to enhance trabectedin efficacy and change tumor immunogenicity.

Methods: OC cell lines, Caov-3 and SK-OV-3, CC cell lines, HeLa and OV2008, and patient-derived organoids were used as study models. MTT and 3D cell viability assays were used for drug(s) IC50 determination. The analysis of apoptosis, JC-1 mitochondrial membrane depolarization, cell cycle, and protein expression was performed by flow cytometry. Cell target modulation analyses were carried out by gene expression, Western blotting, immunofluorescence, and immunocytochemistry.

Results: Trabectedin reduced the proliferation of both CC and OC cell lines and notably of CC patient-derived organoids. Mechanistically, trabectedin caused DNA DSBs and S-phase cell cycle arrest. Despite DNA DSBs, cells failed the formation of nuclear RAD51 foci and underwent apoptosis. Under norepinephrine stimulation, propranolol enhanced trabectedin efficacy, further inducing apoptosis through the involvement of mitochondria, Erk1/2 activation, and the increase of inducible COX-2. Notably, trabectedin and propranolol affected the expression of PD1 in both CC and OC cell lines.

Conclusion: Overall, our results show that CC is responsive to trabectedin and provide translational evidence that could benefit CC treatment options. Our study pointed out that combined treatment offset trabectedin resistance caused by β-adrenergic receptor activation in both ovarian and cervical cancer models.
Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice
Authors: Petroff Rebekah L. , Cavalcante Raymond G. , Colacino Justin A. , Goodrich Jaclyn M. , Jones Tamara R. , Lalancette Claudia , Morgan Rachel K. , Neier Kari , Perera Bambarendage P. U. , Rygiel Christine A. , Svoboda Laurie K. , Wang Kai , Sartor Maureen A. , Dolinoy Dana C.
Published: June 2023

Introduction: The developing epigenome changes rapidly, potentially making it more sensitive to toxicant exposures. DNA modifications, including methylation and hydroxymethylation, are important parts of the epigenome that may be affected by environmental exposures. However, most studies do not differentiate between these two DNA modifications, possibly masking significant effects.

Methods: To investigate the relationship between DNA hydroxymethylation and developmental exposure to common contaminants, a collaborative, NIEHS-sponsored consortium, TaRGET II, initiated longitudinal mouse studies of developmental exposure to human-relevant levels of the phthalate plasticizer di(2-ethylhexyl) phthalate (DEHP), and the metal lead (Pb). Exposures to 25 mg DEHP/kg of food (approximately 5 mg DEHP/kg body weight) or 32 ppm Pb-acetate in drinking water were administered to nulliparous adult female mice. Exposure began 2 weeks before breeding and continued throughout pregnancy and lactation, until offspring were 21 days old. At 5 months, perinatally exposed offspring blood and cortex tissue were collected, for a total of 25 male mice and 17 female mice (n = 5–7 per tissue and exposure). DNA was extracted and hydroxymethylation was measured using hydroxymethylated DNA immunoprecipitation sequencing (hMeDIP-seq). Differential peak and pathway analysis was conducted comparing across exposure groups, tissue types, and animal sex, using an FDR cutoff of 0.15.

Results: DEHP-exposed females had two genomic regions with lower hydroxymethylation in blood and no differences in cortex hydroxymethylation. For DEHP-exposed males, ten regions in blood (six higher and four lower) and 246 regions (242 higher and four lower) and four pathways in cortex were identified. Pb-exposed females had no statistically significant differences in blood or cortex hydroxymethylation compared to controls. Pb-exposed males, however, had 385 regions (all higher) and six pathways altered in cortex, but no differential hydroxymethylation was identified in blood.

Discussion: Overall, perinatal exposure to human-relevant levels of two common toxicants showed differences in adult DNA hydroxymethylation that was specific to sex, exposure type, and tissue, but male cortex was most susceptible to hydroxymethylation differences by exposure. Future assessments should focus on understanding if these findings indicate potential biomarkers of exposure or are related to functional long-term health effects.
High-pressure synthesis of dysprosium carbides
Authors: Akbar Fariia Iasmin , Aslandukova Alena , Aslandukov Andrey , Yin Yuqing , Trybel Florian , Khandarkhaeva Saiana , Fedotenko Timofey , Laniel Dominique , Bykov Maxim , Bykova Elena , Dubrovinskaia Natalia , Dubrovinsky Leonid
Published: June 2023

Chemical reactions between dysprosium and carbon were studied in laser-heated diamond anvil cells at pressures of 19, 55, and 58 GPa and temperatures of ∼2500 K. In situ single-crystal synchrotron X-ray diffraction analysis of the reaction products revealed the formation of novel dysprosium carbides, Dy4C3 and Dy3C2, and dysprosium sesquicarbide Dy2C3 previously known only at ambient conditions. The structure of Dy4C3 was found to be closely related to that of dysprosium sesquicarbide Dy2C3 with the Pu2C3-type structure. Ab initio calculations reproduce well crystal structures of all synthesized phases and predict their compressional behavior in agreement with our experimental data. Our work gives evidence that high-pressure synthesis conditions enrich the chemistry of rare earth metal carbides.