bluuebunny/crossref_metadata_2025 huggingface dataset:
A Tool for the Rapid Seismic Assessment of Historic Masonry Structures Based on Limit Analysis Optimisation and Rocking Dynamics
Authors: Funari Marco Francesco , Mehrotra Anjali , Lourenço Paulo B.
Published: January 2021

This paper presents a user-friendly, CAD-interfaced methodology for the rapid seismic assessment of historic masonry structures. The proposed multi-level procedure consists of a two-step analysis that combines upper bound limit analysis with non-linear dynamic (rocking) analysis to solve for seismic collapse in a computationally-efficient manner. In the first step, the failure mechanisms are defined by means of parameterization of the failure surfaces. Hence, the upper bound limit theorem of the limit analysis, coupled with a heuristic solver, is subsequently adopted to search for the load multiplier’s minimum value and the macro-block geometry. In the second step, the kinematic constants defining the rocking equation of motion are automatically computed for the refined macro-block model, which can be solved for representative time-histories. The proposed methodology has been entirely integrated in the user-friendly visual programming environment offered by Rhinoceros3D + Grasshopper, allowing it to be used by students, researchers and practicing structural engineers. Unlike time-consuming advanced methods of analysis, the proposed method allows users to perform a seismic assessment of masonry buildings in a rapid and computationally-efficient manner. Such an approach is particularly useful for territorial scale vulnerability analysis (e.g., for risk assessment and mitigation historic city centres) or as post-seismic event response (when the safety and stability of a large number of buildings need to be assessed with limited resources). The capabilities of the tool are demonstrated by comparing its predictions with those arising from the literature as well as from code-based assessment methods for three case studies.
A Comparison of Anthropometric and Performance Profiles between Elite and Sub-Elite Hurling Players
Authors: Keane John , Malone Shane , Keogh Ciarán , Young Damien , Coratella Giuseppe , Collins Kieran
Published: January 2021

The aim of the current study was to identify the specific differences in anthropometric and performance profiles between elite and sub-elite hurling players with respect to position and level of play. One hundred and thirty-seven (n = 137) hurlers at the elite (n = 61) and sub-elite (n = 76) level completed a series of anthropometric [height, body mass, the sum of seven skinfolds, adipose tissue percentage estimates (%AT), fat-free mass estimations (FFM)) and performance ((countermovement jump height (CMJ), CMJ peak power (CMJ PP), CMJ relative peak power (CMJ RPP), acceleration (5, 10 and 20 m), and yo-yo intermittent recovery test level 1 (Yo-Yo IRT1)) assessments during the “early in-season” phase of the competition. Data were categorized into positions at both levels (full-backs, half-backs, midfielders, half-forwards, full-forwards). Multiple two-way ANOVA’s were performed to determine the effect of two fixed factors (level and position) on several anthropometric and performance variables. Elite level players had a significantly lower sum of seven skinfolds across all positions compared to the sub-elite (η2 = 0.441, large). At half-back, half-forward, and full-forward elite players had significantly lower %AT (η2 = 0.087–0.167, small–medium) and greater FFM (η2 = 0.040–0.065, small). Jump performance assessment showed elite players performed significantly better across all positions for CMJ (η2 = 0.526, large), CMJ PP (η2 = 0.385, large) and CMJ RPP (η2 = 0.520, large). When Yo-Yo IRT1 was considered, elite players completed an increased distance than the sub-elite across all positions (η2 = 0.526, large). The current data are the first to show differences in positional anthropometric and performance profiles between standards of play within hurling. Applied practitioners should consider these normative data when implementing training programs to maximize position-specific preparation for competition. Furthermore, these data could improve the considerations regarding the transitioning of players from the sub-elite to the elite level of play.
Numerical Study on Temperature Distribution of Steel Truss Aqueducts under Solar Radiation
Authors: Chang Haocheng , Hu Xiaohong , Ma Rujin
Published: January 2021

Aqueduct, one kind of bridge structure overpassing a long space, is a significant structure for water delivery for the purpose of agricultural or domestic usage. Aqueduct has quite different loads from other forms of bridges, of which temperature effects due to the environment temperature change, such as seasonal weather or radiation from sunshine, are of great importance. With water flowing inside, the temperature boundary of aqueducts, especially for steel aqueducts, is much more complicated, and relevant researches are limited. In this paper, a 3D Finite Element Method (FEM) simulation process is presented to analyze temperature distribution on the cross-section of a new-type steel truss aqueduct, which belongs to the Water Transfer Project from Yangtze River to Huai River in China. ASHRAE clear-sky model is used to calculate the solar-radiation variation, including direct radiation, diffuse sky radiation, and ground reflected radiation on steel surfaces. The time-dependent sunshine radiation angle of incidence and shielding effect of steel trusses are considered. The water inside the aqueduct is also included in this model, which significantly influences the temperatures of the inner surfaces of the aqueduct. Several temperature distributions under critical conditions of winter and summer are shown in this study, and results of the empty aqueduct under the same circumstances are also provided as a comparison. The effects of wind speed, geographic latitude, and direction of the aqueduct are examined. The conclusions and approach provided by this study could serve as significant references for thermal design and control of similar steel truss aqueducts.
Defense and Offense Strategies: The Role of Aspartic Proteases in Plant–Pathogen Interactions
Authors: Figueiredo Laura , Santos Rita B. , Figueiredo Andreia
Published: January 2021

Plant aspartic proteases (APs; E.C.3.4.23) are a group of proteolytic enzymes widely distributed among different species characterized by the conserved sequence Asp-Gly-Thr at the active site. With a broad spectrum of biological roles, plant APs are suggested to undergo functional specialization and to be crucial in developmental processes, such as in both biotic and abiotic stress responses. Over the last decade, an increasing number of publications highlighted the APs’ involvement in plant defense responses against a diversity of stresses. In contrast, few studies regarding pathogen-secreted APs and AP inhibitors have been published so far. In this review, we provide a comprehensive picture of aspartic proteases from plant and pathogenic origins, focusing on their relevance and participation in defense and offense strategies in plant–pathogen interactions.
Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
Authors: Ikarashi Nobutomo , Mizukami Nanaho , Pei Chenchen , Uchino Ryogo , Fujisawa Izumi , Fukuda Natsuko , Kon Risako , Sakai Hiroyasu , Kamei Junzo
Published: January 2021

Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice. Blood glucose levels were unchanged in 5-week-old db/db mice compared to db/+ mice (control mice), but the pathophysiology of type 2 diabetes was confirmed in 12-week-old db/db mice. The dermal water content and AQP3 expression in 5-week-old db/db mice were almost the same as those in the control mice. On the other hand, in 12-week-old db/db mice, the dermal water content and AQP3 expression were significantly decreased. The addition of glucose to HaCaT cells had no effect on AQP3, but tumor necrosis factor-α (TNF-α) decreased the AQP3 expression level. Blood TNF-α levels or skin inflammation markers in the 12-week-old db/db mice were significantly higher than those in control mice. AQP3 levels in the skin were decreased in type 2 diabetes, and this decrease in AQP3 may be one of the causes of xeroderma. Therefore, a substance that increases AQP3 may be useful for improving xeroderma. Additionally, a decrease in skin AQP3 may be triggered by inflammation. Therefore, anti-inflammatory drugs may be effective as new therapeutic agents for diabetic xerosis.
ROR2 Is Epigenetically Regulated in Endometrial Cancer
Authors: Liu Dongli , Enriquez Luis , Ford Caroline E.
Published: January 2021

The Wnt signalling receptor ROR2 has been identified as a possible therapeutic target in numerous cancers; however, its exact role remains unclear. The aim of this study was to investigate the role of ROR2 in endometrial cancer (EC) and the potential mechanism associated with its altered expression. The association between ROR2 mRNA expression levels and clinicopathological parameters, including overall survival (OS), in EC was analysed in The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma (TCGA-UCEC) cohort and GEO dataset GSE17025. Four EC cell lines (KLE, MFE-296, Ishikawa and ARK-1) and eight clinical EC samples were analysed for ROR2 methylation via Combined Bisulphite Restriction Analysis (COBRA) and bisulphite genomic sequencing (BGS). In addition, the functional effects of ROR2 overexpression were investigated in Ishikawa and ARK-1 cells following ectopic ROR2 expression. ROR2 promoter methylation or reduced ROR2 expression were both found to correlate with shorter OS, high grade and serous subtype in the TCGA-UCEC and GEO datasets. ROR2 was epigenetically silenced by promoter methylation in both patient samples and cell lines. A significant correlation between ROR2 expression levels and promoter methylation was observed in patient samples (r = −0.797, p = 0.018). ROR2 restoration in ARK-1 significantly decreased invasion ability, with associated changes in epithelial-mesenchymal transition (EMT) markers. ROR2 plays a tumour-suppressor role in EC and is epigenetically suppressed with the development of disease. It may represent a diagnostic or therapeutic candidate for EC.
Surgical Advances in Osteosarcoma
Authors: Brookes Marcus J. , Chan Corey D. , Baljer Bence , Wimalagunaratna Sachin , Crowley Timothy P. , Ragbir Maniram , Irwin Alistair , Gamie Zakareya , Beckingsale Thomas , Ghosh Kanishka M. , Rankin Kenneth S.
Published: January 2021

Osteosarcoma (OS) is the most common primary bone cancer in children and, unfortunately, is associated with poor survival rates. OS most commonly arises around the knee joint, and was traditionally treated with amputation until surgeons began to favour limb-preserving surgery in the 1990s. Whilst improving functional outcomes, this was not without problems, such as implant failure and limb length discrepancies. OS can also arise in areas such as the pelvis, spine, head, and neck, which creates additional technical difficulty given the anatomical complexity of the areas. We reviewed the literature and summarised the recent advances in OS surgery. Improvements have been made in many areas; developments in pre-operative imaging technology have allowed improved planning, whilst the ongoing development of intraoperative imaging techniques, such as fluorescent dyes, offer the possibility of improved surgical margins. Technological developments, such as computer navigation, patient specific instruments, and improved implant design similarly provide the opportunity to improve patient outcomes. Going forward, there are a number of promising avenues currently being pursued, such as targeted fluorescent dyes, robotics, and augmented reality, which bring the prospect of improving these outcomes further.
Cancers in Agreement? Exploring the Cross-Talk of Cancer Metabolomic and Transcriptomic Landscapes Using Publicly Available Data
Authors: van Tilborg Derek , Saccenti Edoardo
Published: January 2021

One of the major hallmarks of cancer is the derailment of a cell’s metabolism. The multifaceted nature of cancer and different cancer types is transduced by both its transcriptomic and metabolomic landscapes. In this study, we re-purposed the publicly available transcriptomic and metabolomics data of eight cancer types (breast, lung, gastric, renal, liver, colorectal, prostate, and multiple myeloma) to find and investigate differences and commonalities on a pathway level among different cancer types. Topological analysis of inferred graphical Gaussian association networks showed that cancer was strongly defined in genetic networks, but not in metabolic networks. Using different statistical approaches to find significant differences between cancer and control cases, we highlighted the difficulties of high-level data-merging and in using statistical association networks. Cancer transcriptomics and metabolomics and landscapes were characterized by changed macro-molecule production, however, only major metabolic deregulations with highly impacted pathways were found in liver cancer. Cell cycle was enriched in breast, liver, and colorectal cancer, while breast and lung cancer were distinguished by highly enriched oncogene signaling pathways. A strong inflammatory response was observed in lung cancer and, to some extent, renal cancer. This study highlights the necessity of combining different omics levels to obtain a better description of cancer characteristics.
Metabolic Effects of Recurrent Genetic Aberrations in Multiple Myeloma
Authors: Bloedjes Timon A. , de Wilde Guus , Guikema Jeroen E. J.
Published: January 2021

Oncogene activation and malignant transformation exerts energetic, biosynthetic and redox demands on cancer cells due to increased proliferation, cell growth and tumor microenvironment adaptation. As such, altered metabolism is a hallmark of cancer, which is characterized by the reprogramming of multiple metabolic pathways. Multiple myeloma (MM) is a genetically heterogeneous disease that arises from terminally differentiated B cells. MM is characterized by reciprocal chromosomal translocations that often involve the immunoglobulin loci and a restricted set of partner loci, and complex chromosomal rearrangements that are associated with disease progression. Recurrent chromosomal aberrations in MM result in the aberrant expression of MYC, cyclin D1, FGFR3/MMSET and MAF/MAFB. In recent years, the intricate mechanisms that drive cancer cell metabolism and the many metabolic functions of the aforementioned MM-associated oncogenes have been investigated. Here, we discuss the metabolic consequences of recurrent chromosomal translocations in MM and provide a framework for the identification of metabolic changes that characterize MM cells.
Active Site Engineering on Two-Dimensional-Layered Transition Metal Dichalcogenides for Electrochemical Energy Applications: A Mini-Review
Authors: Chen Chueh-An , Lee Chiao-Lin , Yang Po-Kang , Tsai Dung-Sheng , Lee Chuan-Pei
Published: January 2021

Two-dimensional-layered transition metal dichalcogenides (2D-layered TMDs) are a chemically diverse class of compounds having variable band gaps and remarkable electrochemical properties, which make them potential materials for applications in the field of electrochemical energy. To date, 2D-layered TMDs have been wildly used in water-splitting systems, dye-sensitized solar cells, supercapacitors, and some catalysis systems, etc., and the pertinent devices exhibit good performances. However, several reports have also indicated that the active sites for catalytic reaction are mainly located on the edge sites of 2D-layered TMDs, and their basal plane shows poor activity toward catalysis reaction. Accordingly, many studies have reported various approaches, namely active-site engineering, to address this issue, including plasma treatment, edge site formation, heteroatom-doping, nano-sized TMD pieces, highly curved structures, and surface modification via nano-sized catalyst decoration, etc. In this article, we provide a short review for the active-site engineering on 2D-layered TMDs and their applications in electrochemical energy. Finally, the future perspectives for 2D-layered TMD catalysts will also be briefly discussed.
Development of an Interactive Lifestyle Programme for Adolescents at Risk of Developing Type 2 Diabetes: PRE-STARt
Authors: Harrington Deirdre M. , Brady Emer M. , Weihrauch-Bluher Susann , Edwardson Charlotte L. , Gray Laura J. , Hadjiconstantinou Michelle , Jarvis Janet , Khunti Kamlesh , Vergara Itziar , Erreguerena Irati , Ribeiro Rogério T. , Troughton Jacqui , Vazeou Andriani , Davies Melanie J.
Published: January 2021

Background: Type 2 diabetes (T2D) is increasing in young people. Reporting on the processes used when developing prevention interventions is needed. We present the development of a family-based interactive lifestyle intervention for adolescents with risk factors for T2D in the future. Method: A multidisciplinary team in the UK site led the intervention development process with sites in Portugal, Greece, Germany and Spain. Potential programme topics and underpinning theory were gathered from literature and stakeholders. A theoretical framework based on self-efficacy theory and the COM-B (capability, opportunity, motivation, behaviour) model was developed. Sessions and supporting resources were developed and refined via two iterative cycles of session and resource piloting, feedback, reflection and refinement. Decision on delivery and content were made by stakeholders (young people, teachers, parents, paediatricians) and all sites. Materials were translated to local languages. Site-specific adaptations to the language, content and supporting resources were made. Results: The “PRE-STARt” programme is eight 90-min interactive sessions with supporting curriculum and resources. Iterative development work provided valuable feedback on programme content and delivery. Conclusion: Reporting on the intervention development process, which includes stakeholder input, could yield a flexible approach for use in this emerging ‘at risk’ groups and their families.
Music-Based Interventions in Paediatric and Adolescents Oncology Patients: A Systematic Review
Authors: González-Martín-Moreno Marta , Garrido-Ardila Elisa María , Jiménez-Palomares María , Gonzalez-Medina Gloria , Oliva-Ruiz Petronila , Rodríguez-Mansilla Juan
Published: January 2021

Background: The implications of cancer and its medical treatment are traumatic, highly stressful and have great psychosocial impact. Therefore, a comprehensive treatment is essential and music-based interventions can play an important role. The objective of this study is to summarise research that assesses the effects of music therapy in paediatric and adolescent patients with cancer during the process of the disease. Methods: A systematic review conducted following PRISMA’s statements. An electronic search of the literature was carried out in the following databases: PubMed, Cochrane, Dialnet, Scopus, IDICEs CSIC and Science Direct. Original studies that conducted music-based interventions with oncology patients between 0 to 18 years old were included. Results: 11 studies were finally included in the review. The sample consisted of two quasi-experimental studies, five randomised clinical controlled trials, one non-randomised controlled trial, one study that involved qualitative and quantitative analysis methods, one descriptive study and one observational study. Conclusions: Music-based interventions decrease anxiety, perceived pain and depression symptoms and improve state of mind, self-esteem and quality of life of paediatric and adolescent patients with cancer. Moreover, they decrease heart rate, respiratory rate and blood pressure and encourage patients to use adaptive coping strategies.
Tailoring the Morphology of Supraparticles by Primary Colloids with Different Shapes, Sizes and Dispersities
Authors: Shim Wonmi , Moon Chan Sik , Kim Hyeonjin , Kim Hyun Su , Zhang Haoxiang , Kang Su Kyung , Lee Pyung Soo , Wooh Sanghyuk
Published: January 2021

Surface-templated evaporation driven (STED) method is a promising method to fabricate supraparticles with various sizes, porosities, and shapes by drying colloidal dispersion drops on liquid repellent surfaces. Until now, for the method, only spherical shaped colloidal particles have been used as primary colloids. Here, we introduce six different shapes of nano-colloidal dispersions for the STED method: nanocubics, nanoplates, nanosheets, coffin-shaped nanoparticles (NPs), spherical NPs, and aggregates of NPs. It is confirmed that the shape and size of the primary colloids have little effect for drying the dispersion drop when a single component colloidal dispersion is dried. For heterogeneous supraparticles with composite material assembly, still the shape of the colloids has no influences, while the size and dispersity play roles for tuning the morphology of the supraparticles. From the results, we propose a way to fabricate homogeneous mixture, core/shell, and Janus core/shell structures of the supraparticles depending on the size and dispersity of the mixture colloidal dispersion. Indeed, knowledge on the effects of types of colloids would be of great importance for tailoring supraparticles.
Integrating Patient-Centred Research in the Canadian Cancer Trials Group
Authors: Needham J. , Taylor J. , Nomikos D.
Published: January 2021

The inclusion of patients as partners in research is a key link in the delivery of patient-centred care in healthcare systems. Despite genuine intentions to engage patients in authentic partnerships, efforts can result in tokenism and benefits of engagement are missed. Understanding how patient engagement provides value along the research to patient-care continuum and how to best engage patients as partners are key. This document describes the method taken by the Canadian Cancer Trials Group (CCTG) to implement meaningful patient centricity and engagement and the benefits realized. Originally, Patient Representatives were recruited and assigned to CCTG Committees. Lacking guidance, the role was one of a passive meeting attendee. A gap analysis identified a need for clarity in expectations, understanding of the linkage to CCTG strategic objectives, and supporting tools and training. A plan was developed and successfully implemented in three phases, each phase building on the previous, the level of patient engagement simultaneously changing from “Inform” to “Involve” to “Collaborate” on the International Association for Public Participation (IAP2) scale. Results include significant contributions to increased patient accrual in CCTG trials, to increased CCTG grant funding, as well as recognition and adoption of these practices within Canada and internationally.
Acknowledgment to Reviewers of Diversity in 2020
Authors:   Diversity Editorial Office
Published: January 2021

Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Diversity maintains its standards for the high quality of its published papers [...]
On-Road Detection of Driver Fatigue and Drowsiness during Medium-Distance Journeys
Authors: Salvati Luca , d’Amore Matteo , Fiorentino Anita , Pellegrino Arcangelo , Sena Pasquale , Villecco Francesco
Published: January 2021

Background: The detection of driver fatigue as a cause of sleepiness is a key technology capable of preventing fatal accidents. This research uses a fatigue-related sleepiness detection algorithm based on the analysis of the pulse rate variability generated by the heartbeat and validates the proposed method by comparing it with an objective indicator of sleepiness (PERCLOS). Methods: changes in alert conditions affect the autonomic nervous system (ANS) and therefore heart rate variability (HRV), modulated in the form of a wave and monitored to detect long-term changes in the driver’s condition using real-time control. Results: the performance of the algorithm was evaluated through an experiment carried out in a road vehicle. In this experiment, data was recorded by three participants during different driving sessions and their conditions of fatigue and sleepiness were documented on both a subjective and objective basis. The validation of the results through PERCLOS showed a 63% adherence to the experimental findings. Conclusions: the present study confirms the possibility of continuously monitoring the driver’s status through the detection of the activation/deactivation states of the ANS based on HRV. The proposed method can help prevent accidents caused by drowsiness while driving.
Insights on the Impacts of Hydroclimatic Extremes and Anthropogenic Activities on Sediment Yield of a River Basin
Authors: Talchabhadel Rocky , Panthi Jeeban , Sharma Sanjib , Ghimire Ganesh R. , Baniya Rupesh , Dahal Piyush , Baniya Mahendra B. , K.C. Shivaram , Jha Biswo , Kaini Surendra , Dahal Kshitij , Gnyawali Kaushal R. , Parajuli Binod , Kumar Saurav
Published: January 2021

Streamflow and sediment flux variations in a mountain river basin directly affect the downstream biodiversity and ecological processes. Precipitation is expected to be one of the main drivers of these variations in the Himalayas. However, such relations have not been explored for the mountain river basin, Nepal. This paper explores the variation in streamflow and sediment flux from 2006 to 2019 in central Nepal’s Kali Gandaki River basin and correlates them to precipitation indices computed from 77 stations across the basin. Nine precipitation indices and four other ratio-based indices are used for comparison. Percentage contributions of maximum 1-day, consecutive 3-day, 5-day and 7-day precipitation to the annual precipitation provide information on the severity of precipitation extremeness. We found that maximum suspended sediment concentration had a significant positive correlation with the maximum consecutive 3-day precipitation. In contrast, average suspended sediment concentration had significant positive correlations with all ratio-based precipitation indices. The existing sediment erosion trend, driven by the amount, intensity, and frequency of extreme precipitation, demands urgency in sediment source management on the Nepal Himalaya’s mountain slopes. The increment in extreme sediment transports partially resulted from anthropogenic interventions, especially landslides triggered by poorly-constructed roads, and the changing nature of extreme precipitation driven by climate variability.
The Impact of Transportation on the Croatian Economy: The Input–Output Approach
Authors: Vukić Luka , Mikulić Davor , Keček Damira
Published: January 2021

The aim of this paper was to determine the economic impact of the transportation sector on the Croatian economy by using input–output analysis. According to the input–output tables for the Croatian economy for 2004, 2010, 2013, and 2015, output and gross value-added multipliers were calculated. The results of the conducted analysis indicated that the multiplicative effects of the transportation sector in Croatia were significant in the observed period, especially for the air transport sector. Furthermore, comparative multiplier analysis with selected European Union countries was performed to assess the Croatian transportation industry position from an international perspective. Lower output and gross value-added multipliers for the Croatian transportation sector imply that old European Union member states capitalized the transportation sector more for growth and development. The Croatian transportation sector recorded lower imported intermediate inputs, average domestic inputs, and higher value-added multipliers similar to new European Union members. Simulations based on multiplicative effects show that restrictions on movements and human contacts, imposed due to the COVID-19 pandemic, could induce a strong reduction in the economic activity of transport and other sectors that are included in the value-added chain of the transport industry.
Impact of Absorbers on the Shielding Effectiveness of Metallic Rooms with Apertures
Authors: Kwon Jong Hwa , Hyoung Chang Hee , Hwang Jung-Hwan , Park Hyun Ho
Published: January 2021

An electromagnetic field penetrating through an aperture or slot of a metallic enclosure generates many standing-waves due to the resonance inside the metallic enclosure, which results in reduced shielding performance. This paper examines the effect of absorbent material (absorber) to improve shielding effectiveness (SE) of large metallic rooms with apertures or slots. First, a theoretical formulation to extract the Q-factor of an absorber with any shape is proposed. Using this, the contribution of the absorber to the SE improvement of a shielded room with different sized circular apertures was investigated. Second, the resonant mode density inside the shielded room was classified into non-resonant, under-moded, and over-moded states with an increase in frequency, and the effect of the absorber in each frequency range was examined. The analysis was conducted through numerical simulation using a commercial full-wave simulator and experimental measurement using a fabricated actual shielded room and commercial absorbers. The accuracy of the analysis results was verified through the comparison of simulated and measured results. The analysis results ensured that the absorber was not effective in improving the SE in the non-resonant state of the metallic room. It was also confirmed that the absorber was effective in improving the SE in the over-moded state of the metallic room where a severe standing-wave occurs. In addition, the SE improvement level differed depending on the location of the absorber in the room.
Spatially-Resolved Multiply-Excited Autofluorescence and Diffuse Reflectance Spectroscopy: SpectroLive Medical Device for Skin In Vivo Optical Biopsy
Authors: Blondel Walter , Delconte Alain , Khairallah Grégoire , Marchal Frédéric , Gavoille Amélie , Amouroux Marine
Published: January 2021

This contribution presents the development of an optical spectroscopy device, called SpectroLive, that allows spatially-resolved multiply-excited autofluorescence and diffuse reflectance measurements. Besides describing the device, this study aims at presenting the metrological and safety regulation validations performed towards its aimed application to skin carcinoma in vivo diagnosis. This device is made of six light sources and four spectrometers for detection of the back-scattered intensity spectra collected through an optical probe (made of several optical fibers) featuring four source-to-detector separations (from 400 to 1000 µm). In order to be allowed by the French authorities to be evaluated in clinics, the SpectroLive device was successfully checked for electromagnetic compatibility and electrical and photobiological safety. In order to process spectra, spectral correction and metrological calibration were implemented in the post-processing software. Finally, we characterized the device’s sensitivity to autofluorescence detection: excitation light irradiance at the optical probe tip in contact with skin surface ranges from 2 to 11 W/m², depending on the light source. Such irradiances combined to sensitive detectors allow the device to acquire a full spectroscopic sequence within 6 s which is a short enough duration to be compatible with optical-guided surgery. All these results about sensitivity and safety make the SpectroLive device mature enough to be evaluated through a clinical trial that aims at evaluating its diagnostic accuracy for skin carcinoma diagnosis.
Automatic Interior Design in Augmented Reality Based on Hierarchical Tree of Procedural Rules
Authors: Kán Peter , Kurtic Andrija , Radwan Mohamed , Rodríguez Jorge M. Loáiciga
Published: January 2021

Augmented reality has a high potential in interior design due to its capability of visualizing numerous prospective designs directly in a target room. In this paper, we present our research on utilization of augmented reality for interactive and personalized furnishing. We propose a new algorithm for automated interior design which generates sensible and personalized furniture configurations. This algorithm is combined with mobile augmented reality system to provide a user with an interactive interior design try-out tool. Personalized design is achieved via a recommender system which uses user preferences and room data as input. We conducted three user studies to explore different aspects of our research. The first study investigated the user preference between augmented reality and on-screen visualization for interactive interior design. In the second user study, we studied the user preference between our algorithm for automated interior design and optimization-based algorithm. Finally, the third study evaluated the probability of sensible design generation by the compared algorithms. The main outcome of our research suggests that augmented reality is viable technology for interactive home furnishing.
To Represent Electric Vehicles in Electricity Systems Modelling—Aggregated Vehicle Representation vs. Individual Driving Profiles
Authors: Taljegard Maria , Göransson Lisa , Odenberger Mikael , Johnsson Filip
Published: January 2021

This study describes, applies, and compares three different approaches to integrate electric vehicles (EVs) in a cost-minimising electricity system investment model and a dispatch model. The approaches include both an aggregated vehicle representation and individual driving profiles of passenger EVs. The driving patterns of 426 randomly selected vehicles in Sweden were recorded between 30 and 73 days each and used as input to the electricity system model for the individual driving profiles. The main conclusion is that an aggregated vehicle representation gives similar results as when including individual driving profiles for most scenarios modelled. However, this study also concludes that it is important to represent the heterogeneity of individual driving profiles in electricity system optimisation models when: (i) charging infrastructure is limited to only the home location in regions with a high share of solar and wind power in the electricity system, and (ii) when addressing special research issues such as impact of vehicle-to-grid (V2G) on battery health status. An aggregated vehicle representation will, if the charging infrastructure is limited to only home location, over-estimate the V2G potential resulting in a higher share (up to 10 percentage points) of variable renewable electricity generation and an under-estimation of investments in both short- and long-term storage technologies.
Natural Radioactivity in Thermal Waters: A Case Study from Poland
Authors: Nguyen Dinh Chau , Nowak Jakub
Published: January 2021

A natural radioactivity in thermal water was investigated based on 19 selected thermal waters from Poland. The analysed results show that the radionuclides’ concentrations in the study waters vary over a wide range. The temperature of the waters varies from above 20 °C to above 80 °C. The waters are characterised by different mineralisation, chemical compositions, and belong to different hydrochemical types. There is a good correlation between the water temperature and the depths of the aquifer formations occurrence, suggesting the thermal energy originates from the thermal geogradient. The concentration of radium is well correlated with the water mineralisation. The ratio of radium activity (226Ra/228Ra) in groundwater relates not only the ratio of uranium activity to that of thorium (238U/232Th) in aquifer formation, but also depends on the physical and chemical water properties. Based on the concentration of radon and its transport model, the radiation exposures due to inhalation of 222Rn and its progeny for employees and clients of the spa were assessed. The use of the thermal waters as a drinking resource may be problematic due to the possibility of exceeding the recommended annual committed effective dose 0.1 mSv.
Implementation of Resilient Self-Healing Microgrids with IEC 61850-Based Communications
Authors: Hong Junho , Ishchenko Dmitry , Kondabathini Anil
Published: January 2021

Due to the high penetration of distributed energy resources (DER) and emerging DER interconnection and interoperability requirements, fast and standardized information exchange is essential for stable, resilient, and reliable operations in microgrids. This paper proposes fast fault detection, isolation, and restoration (F-FDIR) for microgrid application with the IEC 61850 Generic Object Oriented Substation Event (GOOSE) communication considering the communication/system failure. GOOSE provides a mechanism for lightweight low latency peer-to-peer data exchange between devices, which reduces the restoration time compared to conventional client-server communication paradigm. The proposed mitigation method for the communication/system failure can find an available restoration scenario and reduce the overall process time. Hardware-in-the-loop (HIL) testbed is designed and implemented with real time digital simulator, microgrid control system, and protection and control intelligent electric devices (IEDs) for the validation. The experimental results show that the proposed F-FDIR and IEC 61850 models can enhance the reliability and interoperability of the microgrid operation and enable self-healing microgrids.
The Influence of Weather on the Occurrence of Aflatoxin B1 in Harvested Maize from Kenya and Tanzania
Authors: Temba Benigni A. , Darnell Ross E. , Gichangi Anne , Lwezaura Deogratias , Pardey Philip G. , Harvey Jagger J. , Karanja James , Massomo Said M. S. , Ota Noboru , Wainaina James M. , Fletcher Mary T. , Kriticos Darren J.
Published: January 2021

A study was conducted using maize samples collected from different agroecological zones of Kenya (n = 471) and Tanzania (n = 100) during the 2013 maize harvest season to estimate a relationship between aflatoxin B1 concentration and occurrence with weather conditions during the growing season. The toxins were analysed by the ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. Aflatoxin B1 incidence ranged between 0–100% of samples in different regions with an average value of 29.4% and aflatoxin concentrations of up to 6075 µg/kg recorded in one sample. Several regression techniques were explored. Random forests achieved the highest overall accuracy of 80%, while the accuracy of a logistic regression model was 65%. Low rainfall occurring during the early stage of the maize plant maturing combined with high temperatures leading up to full maturity provide warning signs of aflatoxin contamination. Risk maps for the two countries for the 2013 season were generated using both random forests and logistic regression models.
Contrast-Enhanced Ultrasound LI-RADS LR-5 in Hepatic Tuberculosis: Case Report and Literature Review of Imaging Features
Authors: Forgione Antonella , Tovoli Francesco , Ravaioli Matteo , Renzulli Matteo , Vasuri Francesco , Piscaglia Fabio , Granito Alessandro
Published: January 2021

Background: The liver is involved in disseminated tuberculosis in more than 80% of cases while primary liver involvement is rare, representing <1% of all cases. Hepatic tuberculosis (TB) can be treated by conventional anti-TB therapy; however, diagnosing this disease remains a challenge. The diagnosis might be particularly difficult in patients with a single liver lesion that could be misdiagnosed as a tumor or other focal liver lesions. Although computed tomography (CT) and magnetic resonance imaging (MRI) findings have been described, there is a paucity of literature on contrast-enhanced ultrasound (CEUS) features of hepatic TB. Case Summary: herein, we describe a case of a patient with tuberculous lymphadenopathy and chronic Hepatitis C Virus (HCV)-related liver disease who developed a single macronodular hepatic TB lesion. Due to the finding of a hepatocellular carcinoma (HCC) highly suggestive CEUS pattern, specifically a LR5 category according to the Liver Imaging Reporting and Data System (LI-RADS), and a good response to antitubercular therapy, a non-invasive diagnosis of HCC was made, and the patient underwent liver resection. We also review the published literature on imaging features of hepatic TB and discuss the diagnostic challenge represented by hepatic TB when occurs as a single focal liver lesion. Conclusions: this report shows for the first time that the CEUS pattern of hepatic TB might be misinterpreted as HCC and specific imaging features are lacking. Personal history and epidemiological data are mandatory in interpreting CEUS findings of a focal liver lesion even when the imaging pattern is highly suggestive of HCC.
Characterization of New ATM Deletion Associated with Hereditary Breast Cancer
Authors: Parenti Sandra , Rabacchi Claudio , Marino Marco , Tenedini Elena , Artuso Lucia , Castellano Sara , Carretta Chiara , Mallia Selene , Cortesi Laura , Toss Angela , Barbieri Elena , Manfredini Rossella , Luppi Mario , Trenti Tommaso , Tagliafico Enrico
Published: January 2021

Next-generation sequencing (NGS)-based cancer risk screening with multigene panels has become the most successful method for programming cancer prevention strategies. ATM germ-line heterozygosity has been described to increase tumor susceptibility. In particular, families carrying heterozygous germ-line variants of ATM gene have a 5- to 9-fold risk of developing breast cancer. Recent studies identified ATM as the second most mutated gene after CHEK2 in BRCA-negative patients. Nowadays, more than 170 missense variants and several truncating mutations have been identified in ATM gene. Here, we present the molecular characterization of a new ATM deletion, identified thanks to the CNV algorithm implemented in the NGS analysis pipeline. An automated workflow implementing the SOPHiA Genetics’ Hereditary Cancer Solution (HCS) protocol was used to generate NGS libraries that were sequenced on Illumina MiSeq Platform. NGS data analysis allowed us to identify a new inactivating deletion of exons 19–27 of ATM gene. The deletion was characterized both at the DNA and RNA level.
Sociodemographic Factors Affecting Older People’s Care Dependency in Their Daily Living Environment According to Care Dependency Scale (CDS)
Authors: Puto Grażyna , Sowińska Izabela , Ścisło Lucyna , Walewska Elżbieta , Kamińska Alicja , Muszalik Marta
Published: January 2021

The aim of the research was to determine the influence of sociodemographic factors on older people’s care dependency in their living environment according to the Care Dependency Scale (CDS). Methods: The research was conducted in a group of 151 older people staying in their own homes. The methods applied in the research included a sociodemographic questionnaire and scales including the Abbreviated Mental Test Score (AMTS), CDS, Katz Index of Independence in Activities of Daily Living (ADL), Lawton’s Instrumental Activities of Daily Living (I-ADL), Mini Nutritional Assessment (MNA), and Geriatric Depression Scale (GDS). Results: Gender had a significant impact on the level of care dependency. The surveyed females obtained the medium or high level of dependency more often than males (22.4% vs. 6.1%), and the low level of dependency was significantly more frequent among men than women (p = 0.006). Moreover, the age of the respondents determined their level of care dependency. The subjects with a medium or high level of care dependency were significantly older (p = 0.001). The subjects with a low level of care dependency were more likely to be married than people with a medium/high level (p < 0.001). The level of education had a significant impact on care dependency. A higher level of education correlated with a medium/high level of dependency (p = 0.003). Conclusions: The survey results confirmed that sociodemographic factors have a significant impact on the level of care dependency. When planning care in the home environment, special attention should be paid to older women, who are more likely to lose their independence than men. These women should be given additional support.
The Influence of Snow and Ice Albedo towards Improved Lake Ice Simulations
Authors: Robinson Alexis L. , Ariano Sarah S. , Brown Laura C.
Published: January 2021

Lake ice models are a vital tool for studying the response of ice-covered lakes to changing climates throughout the world. The Canadian Lake Ice Model (CLIMo) is a one-dimensional freshwater ice cover model that simulates Arctic and sub-Arctic lake ice cover well. Modelling ice cover in temperate regions has presented challenges due to the differences in ice composition between northern and temperate region lake ice. This study presents a comparison of measured and modelled ice regimes, with a focus on refining CLIMo for temperate regions. The study sites include two temperate region lakes (MacDonald Lake and Clear Lake, Central Ontario) and two High Arctic lakes (Resolute Lake and Small Lake, Nunavut) where climate and ice cover information have been recorded over three seasons. The ice cover simulations were validated with a combination of time lapse imagery, field measurements of snow depth, snow density, ice thickness and albedo data, and historical ice records from the Canadian Ice Database (for Resolute Lake). Simulations of High Arctic lake ice cover show good agreement with previous studies for ice-on and ice-off dates (MAE 6 to 8 days). Unadjusted simulations for the temperate region lakes show good ice-on timing, but an under-representation of ice thickness, and earlier complete ice-off timing (~3 to 5 weeks). Field measurements were used to adjust the albedo values used in CLIMo, which resulted in improvements to both simulated ice thickness (~3 cm MAE compared to manual measurements), and ice-off timing, within 0 to 7 days (2 days MAE) of observations. These findings suggest regionally specific measurements of albedo can improve the accuracy of lake ice simulations, which further our knowledge of the response of temperate and High Arctic lake ice regimes to climate conditions.
Stream Health Estimation for the Plum Creek Watershed
Authors: Kannan Narayanan
Published: January 2021

Overall health of a stream is one of the powerful indicators for planning mitigation strategies. Currently, available methods to estimate stream health do not look at all the different components of stream health. Based on the statistical parameters obtained from daily streamflow data, water quality data, and index of biotic integrity (IBI), this study evaluated the impacts on all the elements of stream health, such as aquatic species, riparian vegetation, benthic macro-invertebrates, and channel degradation for the Plum Creek watershed in Texas, USA. The method involved the (1) collection of flow data at the watershed outlet; (2) identification of hydrologic change in the streamflow; (3) estimation of hydrologic indicators using NATional Hydrologic Assessment Tool (NATHAT) before alteration and after alteration periods; (4) identification of the most relevant indicators affecting stream health in the watershed based on stream type; (5) preliminary estimation of the existence of stream health using flow duration curves (FDCs); (6) the use of stream health-relevant hydrologic indices with the scoring system of the Dundee Hydrologic Regime Assessment Method (DHRAM). The FDCs plotted together for before and after the alteration periods indicated the likely presence of a stream health problem in the Plum Creek. The NATHAT–DHRAM method showed a likely moderate impact on the health of Plum Creek. The biological assessments carried out, the water quality data monitored, and the land cover during pre- and post-alteration periods documented in a publicly available federal document support the stream health results obtained from this study.