bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the Impact of Surface Topography on Wear Resistance
Authors: Wang Ben , Zhang Wei , Liu Zhongxun
Published: September 2024

The surface texture parameter is a real reflection of the surface topography, which is closely related to the tribological properties of the surface, and the study of the correlation between the surface texture parameter and wear resistance is of great significance in revealing the tribological influence mechanism of the surface and realising the functional manufacturing of the surface. This paper takes the ball-end milling surface as the research object, establishes the three-dimensional simulation model of the surface topography, and analyses the surface topography and the surface texture parameter change rule. Based on the improved correlation analysis model, the correlation characteristics between the surface texture parameters, and between the surface texture parameters and the relative wear rate of per unit sliding distance KV, were investigated, and the prediction model of KV was established based on the surface texture parameters Sku, Sa, Sxp, Sp, and Ssk, and the correctness of the model was verified by experiments. The study in this paper provides a new idea to further reveal the relationship between surface topographical features and wear resistance and to guide the functional manufacturing of surfaces.
In Silico Drug Screening for Hepatitis C Virus Using QSAR-ML and Molecular Docking with Rho-Associated Protein Kinase 1 (ROCK1) Inhibitors
Authors: De Borja Joshua R. , Cabrera Heherson S.
Published: September 2024

The enzyme ROCK1 plays a pivotal role in the disruption of the tight junction protein CLDN1, a downstream effector influencing various cellular functions such as cell migration, adhesion, and polarity. Elevated levels of ROCK1 pose challenges in HCV, where CLDN1 serves as a crucial entry factor for viral infections. This study integrates a drug screening protocol, employing a combination of quantitative structure–activity relationship machine learning (QSAR-ML) techniques; absorption, distribution, metabolism, and excretion (ADME) predictions; and molecular docking. This integrated approach allows for the effective screening of specific compounds, using their calculated features and properties as guidelines for selecting drug-like candidates targeting ROCK1 inhibition in HCV treatment. The QSAR-ML model, validated with scores of 0.54 (R2), 0.15 (RMSE), and 0.71 (CCC), demonstrates its predictive capabilities. The ADME-Docking study’s final results highlight notable compounds from ZINC15, specifically ZINC000071318464, ZINC000073170040, ZINC000058568630, ZINC000058591055, and ZINC000058574949. These compounds exhibit the best ranking Vina scores for protein–ligand binding with the crystal structure of ROCK1 at the C2 pocket site. The generated features and calculated pIC50 bioactivity of these compounds provide valuable insights, facilitating the identification of structurally similar candidates in the ongoing exploration of drugs for ROCK1 inhibition.
Antimicrobial Compounds from Food Waste in Cosmetics
Authors: Silletta Antonio , Mancuso Antonia , d’Avanzo Nicola , Cristiano Maria Chiara , Paolino Donatella
Published: September 2024

The cosmetics industry has experienced rapid growth, driven by consumer demand for products in line with modern lifestyles and technological advances, with greater awareness of the impacts on health and the ecosystem. This review explores the potential use of antibacterial compounds derived from food waste as sustainable alternatives to synthetic preservatives in cosmetic products. Waste obtained from food, including fruit peels, seeds, and plant remnants, is rich in natural bioactives, including polyphenolic compounds and essential oils that exhibit antimicrobial, antioxidant, anti-inflammatory, and soothing features. The integration of these natural ingredients not only improves the shelf-life and safety of cosmetics but also promotes environmentally friendly practices. We discuss the sources and antimicrobial efficacy of these compounds, along with recent technological innovations. This sustainable approach responds to consumer preferences for natural ingredients, reduces food waste, and supports environmental sustainability, ultimately increasing the value and attractiveness of cosmetic products.
Biodiversity as a Tool in the Assessment of the Conservation Status of Coastal Habitats: A Case Study from Calabria (Southern Italy)
Authors: Morabito Antonio , Musarella Carmelo Maria , Caruso Giuseppe , Spampinato Giovanni
Published: September 2024

The Mediterranean coasts are threatened by human activities that alter habitats structure and functionality, modifying vegetation and causing the loss of typical species. The definition of the conservation status of coastal habitats is essential to preserve these fragile environments through planned policies. This study aims to assess the conservation status of the habitats of community interest (sensu EEC Directive 43/92) through the analysis of biodiversity and correlating it with urbanisation. A total of 73 vegetation relevés were carried out, so allowing 13 revealing different habitats to be identified. The total plant species diversity per habitat was measured by means of the H-index, also used to assess naturalness (N), differently considering native, alien, and disturbance species. To correlate the N index with distance from urban centres, a statistical analysis was performed. The analysis showed the highest values of H+ were found in habitats 2240, 2110, 2260, and 2230, while lowest values were observed in habitats 2270* and 2240. The habitats 2270* and 2240, the closest to urban centres, have a lower naturalness score than habitats 1420, 2120, 2250*, and 2270*, where higher naturalness scores have been found and therefore lower levels of disturbance. The criteria and methods discussed in this study can be used in coastal management in order to identify the most sensitive habitats and implement an effective conservation strategy.
Point-of-Care Diagnostics (POCD) in Resource-Limited Settings
Authors: Drain Paul K.
Published: September 2024

Diagnostic testing is critical to provide adequate healthcare, and the emergence of various rapid point-of-care diagnostics (POCD) allows for greater access and broader implementation in resource-limited settings [...]
Assessing Diagnostic Performance of Molecular Culture for Neonatal Sepsis: Protocol of the CHAMPIONS Study
Authors: Groen Jip , van der Kuip Martijn , Budding Dries , Bos Martine P. , Benninga Marc A. , Niemarkt Hendrik J. , de Meij Tim G. J.
Published: September 2024

Managing neonatal sepsis is challenging due to nonspecific clinical signs, hematological markers with poor accuracy, and a lengthy turnaround time for the identification of microorganisms. Delaying the initiation of antibiotics in truly infected infants can lead to severe morbidity and mortality. Therefore, decisions regarding empiric antibiotic treatment are risk stratified, which exposes many uninfected infants to antibiotics. This causes gut microbiota perturbation, unnecessary hospital admissions, and the generation of multi-resistant organisms. High-speed diagnostic assays could expedite discontinuation or avert the initiation of antibiotics in uninfected infants. This study will evaluate the diagnostic performance of molecular culture (MC), a rapid broad-range PCR-based bacterial profiling technique, for diagnosing neonatal sepsis in infants below 90 days old. A multi-center prospective observational cohort study will include infants evaluated for early and late-onset sepsis. Routine evaluation for suspected sepsis includes microbiological cultures of blood. Additionally, blood for MC will be collected. For early-onset sepsis, umbilical cord blood may be used alternatively. Primary outcome is the agreement between MC and conventional blood culture results. Secondary outcome is the agreement of both assays with clinical sepsis using four different, commonly used definitions. Faster diagnostic pathways for sepsis may reduce antibiotic exposure time. Broad-range molecular assays may identify pathogens undetectable by conventional methods. Employment of umbilical cord blood samples for early-onset sepsis diagnosis can resolve challenges in collecting adequate blood volume and could further expedite treatment decisions.
Back to Basics: The Diagnostic Value of a Complete Blood Count in the Clinical Management of COVID-19
Authors: Sayed Anwar A.
Published: September 2024

Since the beginning of the COVID-19 pandemic, scientists have struggled significantly to understand the complexity of COVID-19 pathophysiology. COVID-19 has demonstrated a notoriously unpredictable clinical course. This unpredictability constituted a significant obstacle to clinicians in predicting the disease course among COVID-19 patients, more specifically, in predicting who would develop severe cases and possibly die from the infection. This brief report aims to assess the diagnostic value of using a complete blood count (CBC) and applying high-dimensional analysis, i.e., principal component analysis (PCA), on it to differentiate between patients with mild and severe COVID-19 infection. The data of 855 patients were retrieved from multiple centres in Saudi Arabia. Descriptive statistics, such as counts, percentages, and medians (interquartile ranges) were used to describe patients’ characteristics and CBC parameters. Analytical statistics, such as the Mann–Whitney U test, were used to compare between survivors and non-survivors. PCA was applied using the CBC parameters, and the results were compared between survivors and non-survivors. Patients in this study had a median age of 41, with an almost equal ratio of men to women. Most participants were Saudis, and non-survivors were 13.22% of the total cohort. The median values of all CBC indices were within reference ranges; however, some statistically significant differences were observed between survivors and non-survivors. Non-survivors had lower hemoglobin levels and lower hematocrit, lymphocyte, and eosinophil counts but higher WBC and neutrophil counts compared to survivors. PCA on the CBC results of survivors yielded a significantly different profile than non-survivors, indicating the possibility of its use in the context of COVID-19. The diagnostic value of CBC in the clinical management of COVID-19 should be utilized in clinical guidelines for managing COVID-19 cases.
The Distributed Adaptive Bipartite Consensus Tracking Control of Networked Euler–Lagrange Systems with an Application to Quadrotor Drone Groups
Authors: Li Zhiqiang , He Huiru , Han Chenglin , Lin Boxian , Shi Mengji , Qin Kaiyu
Published: September 2024

Actuator faults and external disturbances, which are inevitable due to material fatigue, operational wear and tear, and unforeseen environmental impacts, cause significant threats to the control reliability and performance of networked systems. Therefore, this paper primarily focuses on the distributed adaptive bipartite consensus tracking control problem of networked Euler–Lagrange systems (ELSs) subject to actuator faults and external disturbances. A robust distributed control scheme is developed by combining the adaptive distributed observer and neural-network-based tracking controller. On the one hand, a new positive definite diagonal matrix associated with an asymmetric Laplacian matrix is constructed in the distributed observer, which can be used to estimate the leader’s information. On the other hand, neural networks are adopted to approximate the lumped uncertainties composed of unknown matrices and external disturbances in the follower model. The adaptive update laws are designed for the unknown parameters in neural networks and the actuator fault factors to ensure the boundedness of estimation errors. Finally, the proposed control scheme’s effectiveness is validated through numerical simulations using two types of typical ELS models: two-link robot manipulators and quadrotor drones. The simulation results demonstrate the robustness and reliability of the proposed control approach in the presence of actuator faults and external disturbances.
Temporally Coherent Video Cartoonization for Animation Scenery Generation
Authors: Rayo Gustavo , Tous Ruben
Published: September 2024

The automatic transformation of short background videos from real scenarios into other forms with a visually pleasing style, like those used in cartoons, holds application in various domains. These include animated films, video games, advertisements, and many other areas that involve visual content creation. A method or tool that can perform this task would inspire, facilitate, and streamline the work of artists and people who produce this type of content. This work proposes a method that integrates multiple components to translate short background videos into other forms that contain a particular style. We apply a fine-tuned latent diffusion model with an image-to-image setting, conditioned with the image edges (computed with holistically nested edge detection) and CLIP-generated prompts to translate the keyframes from a source video, ensuring content preservation. To maintain temporal coherence, the keyframes are translated into grids and the style is interpolated with an example-based style propagation algorithm. We quantitatively assess the content preservation and temporal coherence using CLIP-based metrics over a new dataset of 20 videos translated into three distinct styles.
Research on a New Inverter Control Strategy of Induction Heating Power Supply
Authors: Huang Haibo , Kong Yulin , Chen Jianfei , Jian Wei , Sun Fan , Sui Jixiang , Cheng Shiqing
Published: September 2024

To achieve “high voltage, low current” in the induction heating power circuit, enhance the flexibility of component selection in the circuit, and improve the quality of the inverter’s output waveform, a new control strategy of a single-phase NPC three-level inverter with unipolar frequency-doubling SPWM method is proposed. With the series connection of IGBTs in a single-phase NPC three-level inverter, the voltage withstand requirement of IGBT is reduced by half. The middle four IGBTs are controlled using unipolar frequency-doubling SPWM, while the outer four IGBTs are turned on later and turned off earlier to address the neutral point voltage imbalance issue in the inverter. Simulation results show that, compared with the traditional bipolar SPWM-controlled single-phase full-bridge inverter, the DC-side input voltage of the inverter can be double, and the current flowing through the entire circuit can be halved under the same output power using the proposed method.
The Robust Optimization of Low-Carbon Economic Dispatching for Regional Integrated Energy Systems Considering Wind and Solar Uncertainty
Authors: Zhang Mingguang , Wang Bo , Wei Juan
Published: September 2024

In this paper, a two-stage robust optimization approach is employed to address the variability in renewable energy output by accounting for the uncertainties associated with wind and solar energy. The model aims to achieve a balanced system that is both low-carbon and economically efficient while also being resilient to uncertainties. Initially, a regional integrated energy system model is developed, integrating electricity, gas, and heat. The variability of wind and photovoltaic power outputs is represented using a modifiable uncertainty set. A resilient optimal scheduling model is formulated in two stages, with the objective of minimizing costs under worst-case scenarios. This model is solved iteratively through a column and constraint generation approach. Additionally, the scheduling model incorporates horizontal time shifts and vertical complementary substitutions for carbon trading costs and demand-side loads to avoid excessive conservatism and to manage carbon emissions and energy trading in the regional integrated energy system (RIES). Results show that the two-stage robust optimization approach significantly enhances the system’s resilience to risks and minimizes economic losses. The inclusion of carbon trading mechanisms and the demand response prevents the system from becoming overly robust, which could impede economic growth, while also reducing carbon emissions. The proposed method effectively achieves balanced optimal scheduling for a robust, economical, and low-carbon system.
Ambient Backscatter-Based User Cooperation for mmWave Wireless-Powered Communication Networks with Lens Antenna Arrays
Authors: Guo Rongbin , Yin Rui , Wang Guan , Xu Congyuan , Yuan Jiantao
Published: September 2024

With the rapid consumer adoption of mobile devices such as tablets and smart phones, tele-traffic has experienced a tremendous growth, making low-power technologies highly desirable for future communication networks. In this paper, we consider an ambient backscatter (AB)-based user cooperation (UC) scheme for mmWave wireless-powered communication networks (WPCNs) with lens antenna arrays. Firstly, we formulate an optimization problem to maximize the minimum rate of two users by jointly designing power and time allocation. Then, we introduce auxiliary variables and transform the original problem into a convex form. Finally, we propose an efficient algorithm to solve the transformed problem. Simulation results demonstrate that the proposed AB-based UC scheme outperforms the competing schemes, thus improving the fairness performance of throughput in WPCNs.
Enhanced Rubber Yield Prediction in High-Density Plantation Areas Using a GIS and Machine Learning-Based Forest Classification and Regression Model
Authors: Littidej Patiwat , Kromkratoke Winyoo , Pumhirunroj Benjamabhorn , Buasri Nutchanat , Prasertsri Narueset , Sangpradid Satith , Slack Donald
Published: September 2024

Rubber is a perennial plant grown for natural rubber production, which is used in various global products. Ensuring the sustainability of rubber cultivation is crucial for smallholder farmers and economic development. Accurately predicting rubber yields is necessary to maintain price stability. Remote sensing technology is a valuable tool for collecting spatial data on a large scale. However, for smaller plots of land owned by smallholder farmers, it is necessary to process productivity estimates from high-resolution satellite data that are accurate and reliable. This study examines the impact of spatial factors on rubber yield and evaluates the technical suitability of using grouping analysis with the forest classification and regression (FCR) method. We developed a high-density variable using spatial data from rubber plots in close proximity to each other. Our approach incorporates eight environmental variables (proximity to streamlines, proximity to main river, soil drainage, slope, aspect, NDWI, NDVI, and precipitation) using an FCR model and GIS. We obtained a dataset of 1951 rubber yield locations, which we split into a training set (60%) for model development and a validation set (40%) for assessment using area under the curve (AUC) analysis. The results of the alternative FCR models indicate that Model 1 performs the best. It achieved the lowest root mean square error (RMSE) value of 19.15 kg/ha, the highest R-squared (R2) value (FCR) of 0.787, and also the highest R2 (OLS) value of 0.642. The AUC scores for Model 1, Model 2, and Model 3 were 0.792, 0.764, and 0.732, respectively. Overall, Model 4 exhibited the highest performance according to the AUC scores, while Model 3 performed the poorest with the lowest AUC score. Based on these findings, it can be concluded that Model 1 is the most effective in predicting FCR compared to the other alternative models.
Transport of American Bullfrogs with Moistened Foam and without Foam: Plasma Biochemistry and Erythrogram Responses
Authors: Xavier Alves Adriana , Netto dos Santos Nayara , Andrade Reis Gean Paulo , Lana Mariele , Dias dos Santos Bruno , Oliveira Azevedo Ragli , Rosa Paulino Renan , de Alcântara Costa Frederico Augusto , Abreu Vasconcelos Campelo Daniel , Crovatto Veras Galileu
Published: September 2024

This study aimed to evaluate two transportation methods (with moistened foam and without foam) for 10 h on blood parameters of bullfrogs 0, 6, 12, 24, and 48 h after transportation. There was no mortality. The glucose increased at 0 and 12 h after transportation and returned to baseline at 24 h in both transportations. Triglycerides increased at 0 and 6 h in both transportations and were restored 12 h after transport with foam and 24 h in transport without foam. Plasma proteins and globulins increased at 0 h after transportation under both transportations. After 48 h, there was a reduction in transport without foam. Globulins decreased 48 h under both transportations. Albumin increased at 12, 24, and 48 h after both transportations. Transport with foam had high albumin. The albumin/globulin ratio increased 24 and 48 h after both transportations. The number of erythrocytes increased at 0 h and recovered after 6 h in transport with foam and 12 h in transport without foam. Hematocrit and hemoglobin increased at 0 h and recovered at 6 h in both transportations. MCV increased 48 h after transportation with foam. MCHC decreased 12, 24, and 48 h after both transportations. MCH was lower in the transport carried out with foam.
Analysis of the Influence of the Size of Color-Calibrated Schlieren Filters on the General Sensitivity of Quantitative Schlieren Systems
Authors: Prisăcariu Emilia Georgiana , Prisecaru Tudor , Dombrovschi Mădălin Constantin
Published: September 2024

The quantitative color schlieren technique is renowned for its capacity to convert deflection angles into color ratios. This technique has been instrumental in providing data on 2D flows. The current study delves into assessing how the geometry and optical characteristics of color filters impact the sensitivity of the schlieren system. At present, there are many papers making the assumption that implementing a larger-sized color filter leads to better system sensitivity. However, having more calibration filter positions can lead to measurement errors due to the difficult calibration process. The present investigation focuses on the type of color filters created with a gradual evolution of colors. A turbulent, round water vapor jet serves as the test case. By comparing the results obtained with two different filter sizes, this analysis gives insight into the compromises made between system sensitivity and ease of calibration, helping one to better understand the trade-offs between the above-mentioned parameters. Moreover, the quantitative and qualitative results of the test case are presented to offer more comprehensive insights into quantitative color-calibrated schlieren.
Inhibitory Effects of Lactobionic Acid on Biofilm Formation and Virulence of Staphylococcus aureus
Authors: Kang Shimo , Yang Yahui , Hou Wanwan , Zheng Yan
Published: September 2024

Staphylococcus aureus biofilm is a common bio-contaminant source that leads to food cross-contamination and foodborne disease outbreaks. Hence, there is a need for searching novel antibiofilm agents with potential anti-virulence properties to control S. aureus contamination and infections in food systems. In this study, the antibiofilm effects of lactobionic acid (LBA) against S. aureus and its influence on virulence were explored. The minimum inhibition concentration of LBA on S. aureus was 8 mg/mL. Viable count and crystal violet assays revealed that LBA inhibited and inactivated S. aureus biofilms. Microscopic observations further confirmed the antibiofilm activity of LBA on S. aureus that disrupted the biofilm architecture and inactivated the viable cells in biofilms. Moreover, LBA decreased the release of extracellular DNA (eDNA) and extracellular polysaccharide (EPS) in S. aureus biofilms. LBA suppressed biofilm formation by intervening metabolic activity and reduced virulence secretion by repressing the hemolytic activity of S. aureus. Furthermore, LBA altered the expressions of biofilm- and virulence-related genes in S. aureus, further confirming that LBA suppressed biofilm formation and reduced the virulence secretion of S. aureus. The results suggest that LBA might be useful in preventing and controlling biofilm formation and the virulence of S. aureus to ensure food safety.
Phytochemical Profiling and Antimicrobial Properties of Various Sweet Potato (Ipomoea batatas L.) Leaves Assessed by RP-HPLC-DAD
Authors: Sultana Tasbida , Islam Shahidul , Azad Muhammad Abul Kalam , Akanda Md Jahurul Haque , Rahman Atikur , Rahman Md Sahidur
Published: September 2024

This study aimed to investigate the leaves of six cultivars of Ipomoea batatas L. from the USA, focusing on their Total Polyphenol Content (TPC), Total Flavonoid Content (TFC), antioxidant, and antimicrobial activities. TPC and TFC ranged from 7.29 ± 0.62 to 10.49 ± 1.04 mg TAE/g Dw, and from 2.30 ± 0.04 to 4.26 ± 0.23 mg QE/g Dw, respectively, with the highest values found in the ‘O’Henry’ variety. RP-High-Performance Liquid Chromatography identified six phenolic and flavonoid compounds: caffeic acid, chlorogenic acid, 3,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, and quercetin, excluding gallic acid. The highest levels of these compounds were found in acidified methanolic extracts. Antioxidant activities, measured by ABTS and DPPH assays, showed low IC50 values ranging from 94.6 ± 2.76 to 115.17 ± 7.65 µg/mL, and from 88.83 ± 1.94 to 147.6 ± 1.22 µg/mL. Ferric Ion-Reducing Antioxidant Potential (FRAP) measurements indicated significant antioxidant levels, varying from 1.98 ± 0.14 to 2.83 ± 0.07, with the ‘O’Henry’ variety exhibiting the highest levels. The antimicrobial activity test included five Gram-positive bacteria, three Gram-negative bacteria, and two pathogenic fungi. S. aureus, S. mutans, L. monocytogenes, E. coli, S. dysenteriae, and C. albicans were most susceptible to the methanolic extract. This study underscores the impressive antioxidant and antimicrobial activities of sweet potato leaves, often discarded, making them a valuable source of natural antioxidants, antimicrobials, and other health-promoting compounds.
Comparative Analysis of Frying Performance: Assessing Stability, Nutritional Value, and Safety of High-Oleic Rapeseed Oils
Authors: Zhou Zhenglin , Gao Pan , Zhou Yuan , Wang Xingye , Yin Jiaojiao , Zhong Wu , Reaney Martin J. T.
Published: September 2024

Frying is a critical process in the food industry, where selecting appropriate vegetable oils is key to achieving optimal results. In this study, French fries were fried at 175 °C with five different oils, the changes in the physicochemical indexes and free radical scavenging rate of the oils during the frying process were investigated, and the most suitable oils for frying were identified through comparative analysis using principal component analysis (PCA). We assessed the frying performances of hot-pressed high-oleic-acid rapeseed oil (HHRO), cold-pressed high-oleic-acid rapeseed oil (CHRO), soybean oil, rice bran oil, and palm oil utilizing principal component analysis over an 18 h period. The HHRO and CHRO showed lower acid values (0.31, 0.26 mg/g), peroxide values (2.09, 1.96 g/100 g), p-anisidine values (152.48, 178.88 g/mL), and total polar compound percentages (27.60%, 32.10%) than other oils. Furthermore, both the HHRO and CHRO demonstrated enhanced free radical scavenging abilities, indicative of their higher antioxidant capacities, as corroborated by the PCA results. Benzopyridine, 3-monochloropropane-1,2-diol ester, squalene, tocopherols, and polyphenol from the HHRO and CHRO during frying were compared. A comprehensive examination of harmful substances versus nutrient retention during frying revealed that the HHRO contained fewer hazardous compounds, while CHRO retained more nutrients. Therefore, this study analyzes the oxidation regulation of HHRO in frying applications, highlights the prospects of HHRO for frying in terms of health and economy, and contributes valuable insights for informed vegetable oil selection within the food industry.
A Review on Fish Skin-Derived Gelatin: Elucidating the Gelatin Peptides—Preparation, Bioactivity, Mechanistic Insights, and Strategies for Stability Improvement
Authors: Joy Jean Mary , Padmaprakashan Amruth , Pradeep Akshay , Paul Preethy Treesa , Mannuthy Rosemol Jacob , Mathew Suseela
Published: September 2024

Fish skin-derived gelatin has garnered significant attention recently due to its abundant availability and promising bioactive properties. This comprehensive review elucidates various intricacies concerning fish skin-derived gelatin peptides, including their preparation techniques, bioactive profiles, underlying mechanisms, and methods for stability enhancement. The review investigates diverse extraction methods and processing approaches for acquiring gelatin peptides from fish skin, emphasizing their impact on the peptide composition and functional characteristics. Furthermore, the review examines the manifold bioactivities demonstrated by fish skin-derived gelatin peptides, encompassing antioxidant, antimicrobial, anti-inflammatory, and anticancer properties, elucidating their potential roles in functional food products, pharmaceuticals, and nutraceuticals. Further, mechanistic insights into the functioning of gelatin peptides are explored, shedding light on their interactions with biological targets and pathways. Additionally, strategies aimed at improving the stability of gelatin peptides, such as encapsulation, modification, and integration into delivery systems, are discussed to extend the shelf life and preserve the bioactivity. Overall, this comprehensive review offers valuable insights into using fish skin-derived gelatin peptides as functional ingredients, providing perspectives for future research endeavors and industrial applications within food science, health, and biotechnology.
Innovation in Cassava Bagasse Valorization: Efficiency of Convective Drying Enhanced with Ultrasound and Pulsed Electric Fields
Authors: Serpa-Fajardo José G. , Hernández-Ramos Elvis J. , Andrade-Pizarro Ricardo D. , Aguilar-Lasserre Alberto A. , Fernández-Lambert Gregorio
Published: September 2024

This research proposes an efficient alternative for dehydrating cassava bagasse to address the inherent challenges in the handling, transportation, storage, and preservation of this agro–industrial residue generated in cassava starch production plants. This residue is characterized by high moisture retention, considerable volume, and hydrophilic nature, complicating conventional drying methods. This study evaluates the impact of emerging ultrasound (US) and pulsed electric field (PEF) technologies prior to convective drying to enhance the dehydration efficiency of cassava bagasse, aiming at its valorization and contributing to the sustainability of the cassava starch industry. The findings reveal that pretreatment with ultrasound (US) and pulsed electric fields (PEF) significantly reduces the drying time of cassava bagasse compared to convective drying alone. With probe ultrasound at 26 kHz for 30 min, the drying time is reduced by 72% (3.83 h vs. 14.0 h); with bath ultrasound at 37 kHz for 30 min, it is reduced by 56.0% (6.16 h vs. 14.0 h); and with PEF at 7.5 kV/cm for 30 min, it is reduced by 52.4% (6.66 h vs. 14.0 h). These emerging technologies increased the effective diffusivity and modified the molecular structure of the bagasse, thereby improving mass transfer and drying process efficiency. These results are particularly useful for developing more efficient and sustainable strategies for drying agricultural by-products, with direct implications for the post-industrial treatment of agro–industrial residues with high water content.
Structured Triacylglycerol with Optimal Arachidonic Acid and Docosahexaenoic Acid Content for Infant Formula Development: A Bio-Accessibility Study
Authors: Vázquez Luis , Pardo de Donlebún Blanca , Gutiérrez-Guibelalde Alejandra , Chabni Assamae , Torres Carlos F.
Published: September 2024

Polyunsaturated fatty acids (PUFAs), especially arachidonic acid (ARA) and docosahexaenoic acid (DHA), are extremely important fatty acids for brain development in the fetus and early childhood. Premature infants face challenges obtaining these two fatty acids from their mothers. It has been reported that supplementation with triacylglycerols (TAGs) with an ARA:DHA (w/w) ratio of 2:1 may be optimal for preterm infants, as presented in commercial formulas such as Formulaid™. This study explored methods to produce TAGs with a 2:1 ratio (ARA:DHA), particularly at the more bioavailable sn-2 position of the glycerol backbone. Blending and enzymatic acidolysis of microalgae oil (rich in DHA) and ARA-rich oil yielded products with the desired ARA:DHA ratio, enhancing sn-2 composition compared to Formulaid™ (1.6 for blending and 2.3 for acidolysis versus 0.9 in Formulaid™). Optimal acidolysis conditions were 45 °C, a 1:3 substrate molar ratio, 10% Candida antarctica lipase, and 4 h. The process was reproducible, and scalable, and the lipase could be reused. In vitro digestion showed that 75.5% of the final product mixture was bio-accessible, comprising 19.1% monoacylglycerols, ~50% free fatty acids, 14.6% TAGs, and 10.1% diacylglycerols, indicating better bio-accessibility than precursor oils.
The Effect of High Hydrostatic Pressure (HHP) Induction Parameters on the Formation and Properties of Inulin–Soy Protein Hydrogels
Authors: Florowska Anna , Florowski Tomasz , Goździk Patrycja , Hilal Adonis , Florowska Hanna , Janiszewska-Turak Emilia
Published: September 2024

The aim of this study was to determine the effect of high hydrostatic pressure (HHP) induction parameters on the formation and properties of inulin–soy protein hydrogels. Solutions containing 20 g/100 g of inulin and 3 or 6 g/100 g of soy protein isolate (3 SPI; 6 SPI) were subjected to HHPs of 150, 300, or 500 MPa for 5, 10, or 20 min. The HHP parameters had no significant impact on the effectiveness of hydrogel formation. In most cases, the time of solution pressurization had no significant effect on the characteristics of hydrogels. However, increasing the induction pressure from 150 to 300 MPa resulted in hydrogels with different characteristics being obtained, e.g., more flattened microstructure; higher stability (only 3 SPI); higher yield stress, firmness, and adhesiveness; and lower spreadability. These changes were more noticeable in the hydrogels with lower protein content. An increase in the induction pressure (to 500 MPa) did not result in a significant strengthening of the hydrogel structure. However, in the case of 6 SPI hydrogels, induction with a pressure of 500 MPa had an unfavorable effect on their stability. The results indicate that HHP (300 MPa) can be used as an effective method for strengthening the structure of inulin–protein hydrogels.
Papain Injection Creates a Nucleotomy-like Cavity for Testing Gels in Intervertebral Discs
Authors: Jansen Jan Ulrich , Teixeira Graciosa Quelhas , Vernengo Andrea , Grad Sybille , Neidlinger-Wilke Cornelia , Wilke Hans-Joachim
Published: September 2024

Biomaterials, such as hydrogels, have an increasingly important role in the development of regenerative approaches for the intervertebral disc. Since animal models usually resist biomaterial injection due to high intradiscal pressure, preclinical testing of the biomechanical performance of biomaterials after implantation remains difficult. Papain reduces the intradiscal pressure, creates cavities within the disc, and allows for biomaterial injections. But papain digestion needs time, and cadaver experiments that are limited to 24 h for measuring range of motion (ROM) cannot not be combined with papain digestion just yet. In this study, we successfully demonstrate a new organ culture approach, facilitating papain digestion to create cavities in the disc and the testing of ROM, neutral zone (NZ), and disc height. Papain treatment increased the ROM by up to 109.5%, extended NZ by up to 210.9%, and decreased disc height by 1.96 ± 0.74 mm. A median volume of 0.73 mL hydrogel could be injected after papain treatment, and histology revealed a strong loss of proteoglycans in the remaining nucleus tissue. Papain has the same biomechanical effects as known from nucleotomies or herniations and thus creates a disc model to study such pathologies in vitro. This new model can now be used to test the performance of biomaterials.
Manufacture and Initial Characterisation of RAPIDTM Biodynamic Haematogel, an Autologous Platelet and Leukocyte-Rich Plasma Gel for Diabetic Foot Ulcers
Authors: Olszewska Aleksandra , Duan Jiajing , Javorovic Jana , Chan K. L. Andrew , Rickard James , Pitchford Simon , Forbes Ben
Published: September 2024

This observational study reports the process for the manufacture of RAPIDTM Biodynamic Haematogel and explores the properties of the platelet and leukocyte-rich plasma gels formed. Gels were manufactured from 60 mL of human blood using the protocol of Biotherapy Services. Platelet and leukocyte content, time-to-gel, gel weight and the temporal profile of liquid exudation from the gels were measured, along with the content of growth factors VEGF and PDGF in the releasate. The effect of the releasate on human keratinocyte (HaCat) cell proliferation was also determined. The platelet and leukocyte concentrations in donor blood were 1.60–8.10 × 108 and 1.00 × 106–2.00 × 107 cells/mL, which were concentrated 2.67- and 1.12-fold, respectively, during processing. Structurally weak gels were formed which exuded a clear liquid releasate (77.4% w/w of gel weight over 60 min) that contained 278 pg/mL VEGF and 1319 pg/mL PDGF. The releasate produced concentration-dependent proliferation of HaCat cells: 5–15% releasate produced a 2.7–8.9-fold increase in growth over 48 h. In conclusion, we have described the point-of-care manufacturing protocol and characterised the gel properties of RAPIDTM Biodynamic Haematogel. This is an essential first step towards identifying, understanding and controlling critical processing parameters that impact on this medicinal product’s quality.
Assessing Functional Ankle Instability in Sport: A Critical Review and Bibliometric Analysis
Authors: Alexandre Élio , Monteiro Diogo , SottoMayor Ricardo , Jacinto Miguel , Silva Fernanda M. , Cid Luis , Duarte-Mendes Pedro
Published: September 2024

Functional Ankle Instability (FAI) is the subject of extensive research in sports and other environments. Given the importance of accurately measuring this latent construct, it is imperative to carry out a careful assessment of the available tools. In this context, the aim of this review was to take an in-depth look at the six most cited measurement tools to assess FAI, with a specific focus on patient-reported outcome measures related to ankle and foot. Four electronic databases (Web of Science, Scopus, Pubmed, and SportDiscus) were searched (up to November 2022) to identify the six most cited questionnaires for assessing FAI. Our analysis showed that the most cited questionnaires are the following: the Lower Extremity Functional Scale (LEFS), the Foot Function Index (FFI), the Foot and Ankle Ability Measure (FAAM), the Foot and Ankle Outcome Score (FAOS), the Olerud and Molander Ankle Score (OMAS), and the Cumberland Ankle Instability Tool (CAIT). Each questionnaire was thoroughly assessed and discussed in three sections: Development, Reliability, and Summaries. In addition, bibliometric data were calculated to analyze the relevance of each questionnaire. Despite variations in terms of validity and reliability, conceptualization, structure, and usefulness, the six questionnaires proved to be robust from a psychometric point of view, being widely supported in the literature. The bibliometric analyses suggested that the FAOS ranks first and the FFI ranks sixth in the weighted average of the impact factors of their original publications.
Time Perspective and Perceived Social Isolation: The Role of Social Interaction Anxiety
Authors: Stout Madison E. , Medlin Austin R. , Gupta Ritu , Tsotsoros Cindy E.
Published: September 2024

Time perspective is a theoretical construct that describes how humans perceive time, which can influence decision-making and subsequent behavior. Research has shown that an individual’s dominant time perspective can be linked to increased risk of poor health. This study aimed to investigate the relationships between time perspective and perceived social isolation. Specifically, we examined the role of social interaction anxiety in the relationship between time perspective and perceived social isolation in a normative sample of college-aged individuals. Undergraduates (n = 1780) at a large midwestern university completed an online survey. Results revealed that future-oriented, past-positive, and present-hedonistic time perspectives were significantly negatively associated with perceived social isolation. In contrast, past-negative was positively associated with perceived social isolation, and these relationships were partially explained by social interaction anxiety. Understanding dominant time perspectives can help us to better assess health risk factors and may help to develop interventions to promote healthy behaviors.
School Bullying, Bystander Behavior, and Mental Health among Adolescents: The Mediating Roles of Self-Efficacy and Coping Styles
Authors: Wang Xu , Shi Leiyu , Ding Yunzhi , Liu Bowen , Chen Hongbao , Zhou Wei , Yu Renjie , Zhang Peiyun , Huang Xin , Yang Yong , Wu Zhijun
Published: September 2024

While numerous studies have revealed the impact of different bullying behaviors, such as victimization and perpetration, on the psychological development of adolescents, the exploration of the correlates of positive/negative bystander behaviors and their potential underlying mechanisms remains scarce in China. The present study aims to compare the relationships between mental health and positive versus negative bystander behavior and to clarify whether self-efficacy and coping styles mediate the relationships between mental health and bullying dynamics. The current study was conducted on 11,734 students from 18 secondary schools in Suzhou, China (Meanage = 15.00, SDage = 1.47; 53.8% boys). The information on bullying victimization, perpetration, positive/negative bystander behaviors, as well as self-efficacy, coping styles and mental health variables (including depression, anxiety, sleep disturbance, suicide risk), were collected. Negative bystander behavior was positively associated with mental health problems, while positive bystander behavior was negatively associated with these factors. Also, further analysis showed that coping styles and self-efficacy mediated the relationship between different bullying behaviors and mental health outcomes. The results highlighted the comparison of the correlates of positive and negative bystander behaviors, which were comparably crucial to those of victims and perpetrators for prevention and intervention efforts. Promoting adaptive coping styles and self-efficacy to buffer the deleterious psychological consequences of bullying behavior in adolescents was also important.
Post-Traumatic Cerebral Venous Sinus Thrombosis (PtCVST) Resulting in Increased Intracranial Pressure during Early Post-Traumatic Brain Injury Period: Case Report and Narrative Literature Review
Authors: Theofanopoulos Athanasios , Proklou Athanasia , Miliaraki Marianna , Konstantinou Ioannis , Ntotsikas Konstantinos , Moustakis Nikolaos , Lazarioti Sofia , Papadakis Eleftherios , Kypraios George , Angelidis Georgios , Vaki Georgia , Kondili Eumorfia , Tsitsipanis Christos
Published: September 2024

Post-traumatic cerebral venous sinus thrombosis (ptCVST) often remains underdiagnosed due to the non-specific nature of clinical signs, commonly mimicking severe traumatic brain injury (TBI) manifestations. Early recognition of this rare and potentially life-threatening complication is crucial for the effective management of severe TBI patients in Intensive Care. The present study reports the case of a 66-year-old male who was transferred to the emergency department due to moderate TBI. Initial emergency brain computed tomography (CT) scans revealed certain traumatic lesions, not necessitating any urgent neurosurgical intervention. During his stay in an Intensive Care Unit (ICU), multiple transient episodes of intracranial pressure (ICP) values were managed conservatively, and through placement of an external ventricular drain. Following a series of CT scans, there was a continuous improvement of the initial traumatic hemorrhagic findings despite his worsening clinical condition. This paradox raised suspicion for ptCVST, and a brain CT venography (CTV) was carried out, which showed venous sinus thrombosis close to a concomitant skull fracture. Therapeutic anticoagulant treatment was administered. The patient was discharged with an excellent neurological status. To date, there are no clearly defined guidelines for medical and/or surgical management of patients presenting with ptCVST. Therapy is mainly based on intracranial hypertension control and the maintenance of normal cerebral perfusion pressure (CCP) in the ICU. The mismatch between clinical and imaging findings in patients with TBI and certain risk factors raises the suspicion of ptCVST.
Attitudes and Barriers of Polish Women towards Breastfeeding—Descriptive Cross-Sectional On-Line Survey
Authors: Kolmaga Agnieszka , Dems-Rudnicka Katarzyna , Garus-Pakowska Anna
Published: September 2024

Background: Breastfeeding is the gold standard in infant nutrition. Successful breastfeeding depends on many factors, including the help of medical personnel in teaching breastfeeding, the need for professional work, and breastfeeding-friendly places in public spaces. The main goal was to identify various barriers among mothers to breastfeeding. Methods: This study used a quantitative descriptive research design. We recruited 419 mothers aged at least 18 years old through social media. Results were analysed using Pearson’s chi-squared and Fisher’s tests of independence for pairs of dependent and independent variables. Results: Most often, women gave birth at the age of 25–30, had one or two children, and attended higher education. Almost half of them lived in a large city and gave birth to a child by caesarean section. A total of 83.1% of mothers planned to breastfeed, but not all of them were able to do so for various reasons. One-third of them felt sorry for themselves that they had to change their feeding method. The majority of mothers did not receive sufficient help in the hospital in terms of learning how to breastfeed (61%), did not use the help of a lactation consultant (67%), and answered that there was no lactation consultant in their place of residence (65%). Only 43.2% of mothers returned to work without ceasing breastfeeding. A total of 42% of mothers experienced feelings of embarrassment when breastfeeding in a public place. The most frequently indicated barrier to breastfeeding in a public place was the lack of a suitable location where a woman would feel comfortable, calm, and intimate. Conclusion: There are various barriers towards breastfeeding: too few lactation consultants, problems with breastfeeding when the mother wants to return to work, and unfriendly places for breastfeeding in public spaces. Efforts must be made to support mothers in breastfeeding.