bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 2 from Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity
Authors: Fei Dennis Liang , Sanchez-Mejias Avencia , Wang Zhiqiang , Flaveny Colin , Long Jun , Singh Samer , Rodriguez-Blanco Jezabel , Tokhunts Robert , Giambelli Camilla , Briegel Karoline J. , Schulz Wolfgang A. , Gandolfi A. Jay , Karagas Margaret , Zimmers Teresa A. , Jorda Merce , Bejarano Pablo , Capobianco Anthony J. , Robbins David J.
Published: March 2023

PDF file, 21K, SHH and GLI1 levels are enhanced in primary human UC specimens.
Supplementary Figure 8 from Metastasis Suppressor NM23-H1 Promotes Repair of UV-Induced DNA Damage and Suppresses UV-Induced Melanomagenesis
Authors: Jarrett Stuart G. , Novak Marian , Dabernat Sandrine , Daniel Jean-Yves , Mellon Isabel , Zhang Qingbei , Harris Nathan , Ciesielski Michael J. , Fenstermaker Robert A. , Kovacic Diane , Slominski Andrzej , Kaetzel David M.
Published: March 2023

PDF file - 62K
Supplementary Figure 3 from Metastasis Suppressor NM23-H1 Promotes Repair of UV-Induced DNA Damage and Suppresses UV-Induced Melanomagenesis
Authors: Jarrett Stuart G. , Novak Marian , Dabernat Sandrine , Daniel Jean-Yves , Mellon Isabel , Zhang Qingbei , Harris Nathan , Ciesielski Michael J. , Fenstermaker Robert A. , Kovacic Diane , Slominski Andrzej , Kaetzel David M.
Published: March 2023

PDF file - 59K
Supplementary Figure 4 from Critical Function for Nuclear Envelope Protein TMEM209 in Human Pulmonary Carcinogenesis
Authors: Fujitomo Takashi , Daigo Yataro , Matsuda Koichi , Ueda Koji , Nakamura Yusuke
Published: March 2023

PDF file - 61K, Expression of CDC25A and CDK1 in clinical lung cancer samples
Supplementary Tables 1-6 from AMPKα Modulation in Cancer Progression: Multilayer Integrative Analysis of the Whole Transcriptome in Asian Gastric Cancer
Authors: Kim Yon Hui , Liang Han , Liu Xiuping , Lee Ju-Seog , Cho Jae Yong , Cheong Jae-Ho , Kim Hoguen , Li Min , Downey Thomas J. , Dyer Matthew D. , Sun Yongming , Sun Jingtao , Beasley Ellen M. , Chung Hyun Cheol , Noh Sung Hoon , Weinstein John N. , Liu Chang-Gong , Powis Garth
Published: March 2023

PDF file - 106K
Supplementary Figure 2 from Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor Heterogeneity
Authors: Little Suzanne E. , Popov Sergey , Jury Alexa , Bax Dorine A. , Doey Lawrence , Al-Sarraj Safa , Jurgensmeier Juliane M. , Jones Chris
Published: March 2023

PDF file - 7.6MB
Supplementary Methods from Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
Authors: Hu Yu-Long , DeLay Michael , Jahangiri Arman , Molinaro Annette M. , Rose Samuel D. , Carbonell W. Shawn , Aghi Manish K.
Published: March 2023

PDF file - 92K
Supplementary Figure 7 from LIGHT Delivery to Tumors by Mesenchymal Stem Cells Mobilizes an Effective Antitumor Immune Response
Authors: Zou Weibin , Zheng Huilin , He Tong-Chuan , Chang Jinjia , Fu Yang-Xin , Fan Weimin
Published: March 2023

PDF file - 1.9MB, MSC-L trafficking in vivo in earlier time point
Supplementary Figure 5 from LIGHT Delivery to Tumors by Mesenchymal Stem Cells Mobilizes an Effective Antitumor Immune Response
Authors: Zou Weibin , Zheng Huilin , He Tong-Chuan , Chang Jinjia , Fu Yang-Xin , Fan Weimin
Published: March 2023

PDF file - 2.0MB, MSC-L did not mainly impact on tumor proliferation, apoptosis and angiogenesis
Supplementary Figure Legends 1-2, Table 1 from Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
Authors: Doe Megan R. , Ascano Janice M. , Kaur Mandeep , Cole Michael D.
Published: March 2023

PDf file - 62K
Supplementary Figure 1 from Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
Authors: Doe Megan R. , Ascano Janice M. , Kaur Mandeep , Cole Michael D.
Published: March 2023

PDF file - 97K
Supplementary Figure 5 from Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-Mediated GLUT3 Transcription
Authors: Ha Tae-Kyu , Her Nam-Gu , Lee Min-Goo , Ryu Byung-Kyu , Lee Jin-Hee , Han Jikhyon , Jeong Seong-In , Kang Min-Ju , Kim Nam-Hoon , Kim Hyo-Jong , Chi Sung-Gil
Published: March 2023

PDF file- 41K, A dose-associated decrease in GLUT3 promoter activity by si-CAV1 transfection
Supplementary Figure 5 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 12K, CCN6 overexpression significantly decreased tumor growth in vivo.
Supplementary Tables 1-11 from The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences
Authors: Sainz-Perez Alexander , Lim Annick , Lemercier Brigitte , Leclerc Claude
Published: March 2023

PDF file - 206K, Tables S1-S11 present the TCR sequences of Treg and Teff cells obtained from TC-1 and MO-5 tumor-bearing mice
Supplementary Figure Legends 1-5 from miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
Authors: Majid Shahana , Dar Altaf A. , Saini Sharanjot , Arora Sumit , Shahryari Varahram , Zaman Mohd Saif , Chang Inik , Yamamura Soichiro , Tanaka Yuichiro , Deng Guoren , Dahiya Rajvir
Published: March 2023

PDF file - 70K
Supplementary Figure 3 from miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
Authors: Majid Shahana , Dar Altaf A. , Saini Sharanjot , Arora Sumit , Shahryari Varahram , Zaman Mohd Saif , Chang Inik , Yamamura Soichiro , Tanaka Yuichiro , Deng Guoren , Dahiya Rajvir
Published: March 2023

PDF file - 2MB, Functional assays in androgen dependent LNCaP cells
Supplementary Data from Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Authors: Gilkes Daniele M. , Chaturvedi Pallavi , Bajpai Saumendra , Wong Carmen C. , Wei Hong , Pitcairn Stephen , Hubbi Maimon E. , Wirtz Denis , Semenza Gregg L.
Published: March 2023

Supplementary Data PDF file 764K, Supplementary Figure S1, HIF-1 dependent P4HA1 and P4HA2 induction Supplementary Figure S2, P4HA1 and P4HA2 knockdown inhibits breast cancer growth and metastasis Supplementary Figure S3, Collagen hydroxylase knockdown decreases collagen deposition in vivo Supplementary Figure S4, P4HA1 and P4HA2 knockdown inhibits growth and metastasis of MDA-MB-435 cells Supplementary Figure S5, Picrosirius red staining of mouse lungs Supplementary Figure S6, P4HA re-expression in HIF-deficient cells rescues collagen deposition and metastasis Supplementary Figure S7, DHB treatment of MDA-MB-231 Cells Supplementary Table S1, Real-time qPCR primers. Supplemental Table S2, Comparison of human P4HA1 mRNA versus mouse P4HA1 mRNA expression in tumors. Supplemental Table S3, Correlation of P4HA1 and P4HA2 mRNA expression with receptor status
Supplementary Methods from Exploiting the Mutanome for Tumor Vaccination
Authors: Castle John C. , Kreiter Sebastian , Diekmann Jan , Löwer Martin , van de Roemer Niels , de Graaf Jos , Selmi Abderraouf , Diken Mustafa , Boegel Sebastian , Paret Claudia , Koslowski Michael , Kuhn Andreas N. , Britten Cedrik M. , Huber Christoph , Türeci Özlem , Sahin Ugur
Published: March 2023

PDF file - 101K
Supplementary Figure Legend from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: March 2023

PDF file - 42K
Supplementary Figure Legend from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Authors: Capozza Franco , Trimmer Casey , Castello-Cros Remedios , Katiyar Sanjay , Whitaker-Menezes Diana , Follenzi Antonia , Crosariol Marco , Llaverias Gemma , Sotgia Federica , Pestell Richard G. , Lisanti Michael P.
Published: March 2023

PDF file - 72K
Supplementary Figure 1 from Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma
Authors: Zhu Ying-Hui , Fu Li , Chen Leilei , Qin Yan-Ru , Liu Haibo , Xie Fajun , Zeng Tingting , Dong Sui-Sui , Li Jiangchao , Li Yan , Dai Yongdong , Xie Dan , Guan Xin-Yuan
Published: March 2023

PDF file - 2668K, Supplemental Figure 1. Expression of genes located within chromosome 19p13.3 in 50 paired ESCC and non-tumor clinical samples.
Supplementary Figure 1 from Vaccine-Mediated Immunotherapy Directed against a Transcription Factor Driving the Metastatic Process
Authors: Ardiani Andressa , Gameiro Sofia R. , Palena Claudia , Hamilton Duane H. , Kwilas Anna , King Thomas H. , Schlom Jeffrey , Hodge James W.
Published: March 2023

PDF file - 138KB, Expression of murine Twist protein in S. cerevisiae Yeast.
Supplementary Figure 2 from Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction
Authors: Dash Rupesh , Bhoopathi Praveen , Das Swadesh K. , Sarkar Siddik , Emdad Luni , Dasgupta Santanu , Sarkar Devanand , Fisher Paul B.
Published: March 2023

PDF file - 255K, S2. siRNA-mediated silencing of IL-20R2 or IL-22R receptor pairs in DU-145 and HO-1 cells.
Supplementary Figures 1 - 5 from Sequential Gene Targeting to Make Chimeric Tumor Models with De Novo Chromosomal Abnormalities
Authors: Chambers Jennifer S. , Tanaka Tomoyuki , Brend Tim , Ali Hanif , Geisler Nicola J. , Khazin Leah , Cigudosa Juan C. , Neil Dear T. , MacLennan Kenneth , Rabbitts Terence H.
Published: March 2023

PDF file - 2135K, Fig. S1 Targeting vectors for Mll-ENl fast throughput translocator analysis. Fig. S2 The LMO2-Cre knock in targeting vector. Fig. S3 Comparison of leukaemia incidence rate in the triple targeted chimaeric mice and germline-transmission translocator mice. Fig. S4 Sequence of the genomic PCR product after FLP-mediated deletion. Fig. S5 Analysis of mRNA levels in chimaera-derived tumour cells.
Supplementary Figure 6 from Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Authors: Xie Maohua , Yen Yun , Owonikoko Taofeek K. , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Doetsch Paul W. , Deng Xingming
Published: March 2023

PDF file - 76K, Removal of any BH domain from Bcl2 reduces its anti-apoptotic function.
Supplementary Methods from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells
Authors: Oberg Hans-Heinrich , Peipp Matthias , Kellner Christian , Sebens Susanne , Krause Sarah , Petrick Domantas , Adam-Klages Sabine , Röcken Christoph , Becker Thomas , Vogel Ilka , Weisner Dietrich , Freitag-Wolf Sandra , Gramatzki Martin , Kabelitz Dieter , Wesch Daniela
Published: March 2023

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Supplementary Figure Legends from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells
Authors: Oberg Hans-Heinrich , Peipp Matthias , Kellner Christian , Sebens Susanne , Krause Sarah , Petrick Domantas , Adam-Klages Sabine , Röcken Christoph , Becker Thomas , Vogel Ilka , Weisner Dietrich , Freitag-Wolf Sandra , Gramatzki Martin , Kabelitz Dieter , Wesch Daniela
Published: March 2023

PDF file - 38K
Supporting Materials and Methods; Supporting References from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supporting Materials and Methods; Supporting References
Data Supplement from Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Authors: Tchaicha Jeremy H. , Akbay Esra A. , Altabef Abigail , Mikse Oliver R. , Kikuchi Eiki , Rhee Kevin , Liao Rachel G. , Bronson Roderick T. , Sholl Lynette M. , Meyerson Matthew , Hammerman Peter S. , Wong Kwok-Kin
Published: March 2023

Supplemental Figure 2. FGFR2/CC10 staining of 20 and 32 week FGFR2 lung tumors.
Supplementary Figure 4 from VISTA Regulates the Development of Protective Antitumor Immunity
Authors: Le Mercier Isabelle , Chen Wenna , Lines Janet L. , Day Maria , Li Jiannan , Sergent Petra , Noelle Randolph J. , Wang Li
Published: March 2023

PDF file - 90K, VISTA mab (13F3) did not directly alter Foxp3 stability in cultured Tregs, as well as the proliferation and apoptosis of Tregs.
Supplementary Figure 1 from VISTA Regulates the Development of Protective Antitumor Immunity
Authors: Le Mercier Isabelle , Chen Wenna , Lines Janet L. , Day Maria , Li Jiannan , Sergent Petra , Noelle Randolph J. , Wang Li
Published: March 2023

PDF file - 11K, The serum clearance and immunogenicity of VISTA-specific hamster monoclonal antibody 13F3.
Supplementary Figure 9 from FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation
Authors: Guillemette Shawna , Branagan Amy , Peng Min , Dhruva Aashana , Schärer Orlando D. , Cantor Sharon B.
Published: March 2023

PDF file - 88K, Supplemental Figure 9. FANCJ expression promotes UV induced GFP-polh foci formation in U2OS cells.
Supplementary Figure 4 from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Thadani-Mulero Maria , Portella Luigi , Sun Shihua , Sung Matthew , Matov Alexandre , Vessella Robert L. , Corey Eva , Nanus David M. , Plymate Stephen R. , Giannakakou Paraskevi
Published: March 2023

PDF file - 176KB, LuCap 86.2 and LuCap 23.12 human prostate cancer xenografts treated with docetaxel 5 mg/kg weekly i.p or 20 mg/kg weekly i.p.
Supplementary Figure 6 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

PDF file - 365K, Figure. S6. VHL inhibit HIF-2a and VEGF expression independent AR.
Supplementary FIgure S1 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

Figure. S1. Activation of AR signaling contributes to RCC cells migration, invasion and proliferation.
Supplementary Data 5 from Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma
Authors: Okazaki Hiroyuki , Matsunaga Naoya , Fujioka Takashi , Okazaki Fumiyasu , Akagawa Yui , Tsurudome Yuuya , Ono Mayumi , Kuwano Michihiko , Koyanagi Satoru , Ohdo Shigehiro
Published: March 2023

PDF file - 127K, The influence of exposure time on the anti-proliferative effect of everolimus.
Data Supplement from IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Authors: Venmar Katherine T. , Carter Kathy J. , Hwang Daniel G. , Dozier E. Ashley , Fingleton Barbara
Published: March 2023

Supplemental Figure 5: IL4Ra expression is associated with changes in immune infiltration
Data Supplement from Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells
Authors: Wang Xiao-kun , He Jie-hua , Xu Jing-hong , Ye Sheng , Wang Fang , Zhang Hui , Huang Zhen-cong , To Kenneth Kin Wah , Fu Li-wu
Published: March 2023

Supplementary Figure S2. Representative flow cytometry dot plots of apoptosis analysis in SP cells under exposure to combination of afatinib with topotecan or mitoxantrone were presented.
Supplementary Table 1 from RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma
Authors: Chen Xuebo , Zhang Leying , Zhang Ian Y. , Liang Junling , Wang Huaqing , Ouyang Mao , Wu Shihua , da Fonseca Anna Carolina Carvalho , Weng Lihong , Yamamoto Yasuhiko , Yamamoto Hiroshi , Natarajan Rama , Badie Behnam
Published: March 2023

Supplementary Table 1: Primers used in the real-time quantitative PCR.
Data Supplement from Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer
Authors: Liu Deli , Xiong Huan , Ellis Angela E. , Northrup Nicole C. , Rodriguez Carlos O. , O'Regan Ruth M. , Dalton Stephen , Zhao Shaying
Published: March 2023

Supplementary Table S4. Supplementary data for differentially expressed genes among canine complex carcinomas, simple carcinomas and normal tissues, including the gene list and enriched functions among the genes.
Supplementary Figure 5 from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: March 2023

Supplementary Figure 5. MCF-7:5C cells were transfected with an ERE-luciferase reporter construct for 24 hours, then treated with vehicle, 1µM 4-OHT, 1nM E2, 1µM MPA, 1µM NETA, or combinations for 24 hours. ERE activity was measured by luciferase assay and normalized to vehicle control. Means represent samples in triplicate. Error bars too small to visualize.
Supplemental Figure S1 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: March 2023

Supplemental Figure S1. Related to Figure 1: Generation and characterization of the SNAIL1-CBR mouse
Supplemental Figure Legend from Targeted Noninvasive Imaging of EGFR-Expressing Orthotopic Pancreatic Cancer Using Multispectral Optoacoustic Tomography
Authors: Hudson Shanice V. , Huang Justin S. , Yin Wenyuan , Albeituni Sabrin , Rush Jamie , Khanal Anil , Yan Jun , Ceresa Brian P. , Frieboes Hermann B. , McNally Lacey R.
Published: March 2023

Supplemental Figure Legend. Legend for Supplemental Figure S1.
Supplementary Figure 2 from Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel
Authors: Nieuweboer Annemieke J.M. , Hu Shuiying , Gui Chunshan , Hagenbuch Bruno , Ghobadi Moghaddam-Helmantel Inge M. , Gibson Alice A. , de Bruijn Peter , Mathijssen Ron H.J. , Sparreboom Alex
Published: March 2023

PDF file - 151KB, The uptake of paclitaxel by human OATP1B1, human OATP1B3 in CHO cells (1 microM; 2-min), or mouse OATP1B2 in HEK293 cells (0.1 microM; 15-min) evaluated in the absence (none) or presence of 1 percent (w/v) Cremophor EL (CrEL).
Data Supplement from Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?
Authors: Hatzis Christos , Bedard Philippe L. , Birkbak Nicolai J. , Beck Andrew H. , Aerts Hugo J.W.L. , Stern David F. , Shi Leming , Clarke Robert , Quackenbush John , Haibe-Kains Benjamin
Published: March 2023

Supplementary Table 1 reporting the main steps in the experimental protocol used in the CGP and CCLE studies. Different options were used across studies for most steps, including detection assay, quality assurance of screening plates, controls, and measures of drug potency (IC50), which are further described in Supplementary Information.
Supplementary Figures 1 - 12, Tables 1 - 5 from Favorable Prognostic Impact in Loss of TP53 and PIK3CA Mutations after Neoadjuvant Chemotherapy in Breast Cancer
Authors: Jiang Yi-Zhou , Yu Ke-Da , Bao Jing , Peng Wen-Ting , Shao Zhi-Ming
Published: March 2023

PDF file - 909K, Supplementary Table S1. Validated somatic mutations comparing pre- with post-treatment tumor tissues of P1 and P2 Supplementary Table S2. Distribution of TP53 and PIK3CA mutations Supplementary Table S3. List of TP53 and PIK3CA somatic mutations in breast cancer tissues before and after neoadjuvant chemotherapy Supplementary Table S4. TP53 mutation shift in tumor tissues before and after neoadjuvant chemotherapy in the first cohort (n=206) and second cohort (n=158) Supplementary Table S5. PIK3CA mutation shift in tumor tissues before and after neoadjuvant chemotherapy in the first cohort (n=206) and second cohort (n=158) Supplementary Table S6. Distribution of TP53 and PIK3CA mutation shift in different molecular subtypes of breast cancer in the first cohort (n=206) and second cohort (n=158) Supplementary Table S7. Distribution of TP53 mutation shift in different molecular subtypes of breast cancer in the first cohort (n=206) and second cohort (n=158) Supplementary Table S8. Distribution of PIK3CA mutation shift in different molecular subtypes of breast cancer in the first cohort (n=206) and second cohort (n=158) Supplementary Table S9. Association of TP53 mutation shift with tumor response to neoadjuvant chemotherapy in the first cohort (n=206) and second cohort (n=158) Supplementary Table S10. Association of PIK3CA mutation shift with tumor response to neoadjuvant chemotherapy in the first cohort (n=206) and second cohort (n=158) Supplementary Table S11. Multivariate analysis of disease-free survival including TP53 and PIK3CA mutation status separately Supplementary Table S12. Multivariate analysis of disease-free survival including the combination of TP53 and PIK3CA mutation status Supplementary Fig. S1. Distribution of TP53 (A) and PIK3CA (B) mutations according to different molecular subtypes in pre-treatment breast cancer in the two cohorts. Supplementary Fig. S2. Representative images of hematoxylin and eosin stainings from the post-treatment tumors where mutation loss occurred. Scale bar, 20 �m. Supplementary Fig. S3. Quantification of the frequency of mutant alleles in pre- and post-treatment tumors from which mutation loss occurred (A: loss of TP53 mutations; B; loss of PIK3CA mutations) by pyrosequencing in the two cohorts. Supplementary Fig. S4. Kaplan-Meier estimates of disease-free survival (DFS) and overall survival (OS) according to TP53 mutation shift in the first (A, n=206) and second cohorts (B, n=158). Supplementary Fig. S5. Kaplan-Meier estimates of disease-free survival (DFS) and overall survival (OS) according to PIK3CA mutation shift in the first (A, n=206) and second cohorts (B, n=158).
Supplementary Table 2 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 14912KB, Somatic mutations in protein-coding genes identified in 70 CRC cell lines using exome-capture sequencing.
Supplementary Figures 1 - 4 from In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents
Authors: Henderson Colin J. , McLaren Aileen W. , Wolf C. Roland
Published: March 2023

PDF file - 600K, Supplemental Figure 1: Densitometric scanning of protein bands from Western blots (each track representing pool of n = 3 samples) shown in Figure 3; data are fold-�‐change in expression relative to corn oil control in each genotype for liver, lung, small intestine and large intestine. Supplemental Figure 2: Densitometric scanning of protein bands from Western blots of liver samples (each track representing pool of n = 2 or 3) shown in Figure 4A for Cyp1a, Cyp2a, Cyp2b, Cyp2c and Cyp3a; data are fold-�‐change in expression relative to corn oil control in each genotype. A: Densitometric scanning of protein bands from Western blots (each track representing pool of n = 3 samples) shown in Figure 5 for NQO1, GSTM1 and GSTA1; data are fold-�‐change in expression relative to corn oil control in each genotype for liver, lung, small intestine and large intestine. *Note: The extent of induction of NQO1 in liver samples from Nrf2-�‐/-�‐ mice with EQ and BHA is overestimated due to the almost complete lack of expression of hGSTP1 in the corn oil control samples; raw densitometric data (inset) show the same expression level for NQO1 in EQ-�‐ treated Nrf2-�‐/-�‐ and corn oil-�‐treated Nrf2+/+ samples. B: Densitometric scanning of protein bands from Western blots (each track representing pool of n = 3 samples) shown in Figure 5 for NQO1, GSTM1 and GSTA1; data are fold-�‐change in expression relative Nrf2+/+ genotype for liver, lung, small intestine and large intestine. Supplemental Figure 4: Densitometric scanning of protein bands from Western blots of mouse embryo fibroblasts (+/-�‐ Nrf2) shown in Figure 6; data are fold-�‐change in expression relative to zero time point for β-�‐galactosidase, hGSTP1, HO-�‐1, NQO-�‐1, c-�‐Fos, c-�‐Jun, ERK1/2 and NFkB.
Supplemental Figure S2 from Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake
Authors: Alvarez James V. , Belka George K. , Pan Tien-Chi , Chen Chien-Chung , Blankemeyer Eric , Alavi Abass , Karp Joel S. , Chodosh Lewis A.
Published: March 2023

Supplemental Figure S2. Multivariate analysis of FDG uptake.
Supplementary Table S4 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Table S4. Raw heatmap excel spread sheet file for Fig. 4A.
Supplementary Table S1 from Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations
Authors: Bai Yun , Kim Jae-Young , Watters January M. , Fang Bin , Kinose Fumi , Song Lanxi , Koomen John M. , Teer Jamie K. , Fisher Kate , Chen Yian Ann , Rix Uwe , Haura Eric B.
Published: March 2023

Supplementary Table S1. pY peptides identified by phosphoproteomics in two DDR2 mutation cell line treated with or without 500 nM dasatinib for 3 hour (543, 636 pY peptides in H2286 and HCC366, respectively).
Supplementary Figure S4 from Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma
Authors: Schmithals Christian , Köberle Verena , Korkusuz Hüdayi , Pleli Thomas , Kakoschky Bianca , Augusto Eduardo Alonso , Ibrahim Ahmed Atef , Arencibia Jose M. , Vafaizadeh Vida , Groner Bernd , Korf Horst-Werner , Kronenberger Bernd , Zeuzem Stefan , Vogl Thomas J. , Waidmann Oliver , Piiper Albrecht
Published: March 2023

Supplementary Figure S4: Effect of sorafenib with or without iRGD on MAPK phosphorylation levels in the HepG2 xenografts from the different treatment groups.
Supplementary Figures S1-S5 from Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma
Authors: Kuczynski Elizabeth A. , Lee Christina R. , Man Shan , Chen Eric , Kerbel Robert S.
Published: March 2023

Supplementary Figures S1-S5. Loss of sorafenib resistance in vitro and during transfer of resistant tumor fragments (S1); Sorafenib plasma levels declined in early progressors (S2); Impact of tumor free-mouse treatment on tissue sorafenib metabolite levels and resistance development (S3); Additional effects of dose escalation (S4); Effects of sorafenib treatment on cell signaling pathways in tissues (S5).
Supplementary Table S1 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth
Authors: Ito-Kureha Taku , Koshikawa Naohiko , Yamamoto Mizuki , Semba Kentaro , Yamaguchi Noritaka , Yamamoto Tadashi , Seiki Motoharu , Inoue Jun-ichiro
Published: March 2023

Supplementary Table S1. Primers for the cDNA amplification and semiquantitative and real time RT-PCR.
Supplementary Figure S1 from miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression
Authors: Zoni E. , van der Horst G. , van de Merbel A.F. , Chen L. , Rane J.K. , Pelger R.C.M. , Collins A.T. , Visakorpi T. , Snaar-Jagalska B.E. , Maitland N.J. , van der Pluijm G.
Published: March 2023

Supplementary Figure S1. ALDHhigh prostate cancer cells display enhanced colony formation and migration compared to ALDHlow cells.
Supplementary Table S1 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Expression of hepatic transporters in various knockout mouse models.
Supplementary Figure S4 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Plasma and liver concentrations of sorafenib and SG in wildtype, Abcc3(-/-), Abcc4(-/-) and Abcc3;Abcc4(-/-) mice.
Supplementary Figure S1 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Hepatic uptake and biliary excretion in wildtype and Abcc2(-/-) mice.
Supplementary Figure 4 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Surface expression of CAR during co-culture with tEGFR+ EL4 or CAR-L+ EL4
Supplementary Figure S2 from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications
Authors: Gámez-Pozo Angelo , Berges-Soria Julia , Arevalillo Jorge M. , Nanni Paolo , López-Vacas Rocío , Navarro Hilario , Grossmann Jonas , Castaneda Carlos A. , Main Paloma , Díaz-Almirón Mariana , Espinosa Enrique , Ciruelos Eva , Fresno Vara Juan Ángel
Published: March 2023

Supplementary Figure S2. Hypothesis about how miR449a exerts its regulatory effect over cellular metabolism.
Supplementary Figure S5 from Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells
Authors: Hebeisen Michael , Schmidt Julien , Guillaume Philippe , Baumgaertner Petra , Speiser Daniel E. , Luescher Immanuel , Rufer Nathalie
Published: March 2023

Supplementary Figure S5. Impact of rapid association on-rates on cell surface dissociation kinetics by reversible NTAmers.
Supplementary Figure Legends from Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Authors: Khan Sheema , Ebeling Mara C. , Chauhan Neeraj , Thompson Paul A. , Gara Rishi K. , Ganju Aditya , Yallapu Murali M. , Behrman Stephen W. , Zhao Haotian , Zafar Nadeem , Singh Man Mohan , Jaggi Meena , Chauhan Subhash C.
Published: March 2023

Legends for Supplementary Figures S1-S4.
Supplementary Figure Legends from Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells
Authors: Hebeisen Michael , Schmidt Julien , Guillaume Philippe , Baumgaertner Petra , Speiser Daniel E. , Luescher Immanuel , Rufer Nathalie
Published: March 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S5. Also includes Supplementary References.
Supplementary Figure S1 from CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity
Authors: Yang Chenyi , Boyson Cynthia A. , Di Liberto Maurizio , Huang Xiangao , Hannah Jeffrey , Dorn David C. , Moore Malcolm A.S. , Chen-Kiang Selina , Zhou Pengbo
Published: March 2023

Supplementary Figure S1. Freshly isolated primary CD34+ AML cells maintain the proliferating activity.
Supp. Figure 2 from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence
Published: March 2023

Effect of PTX on the viability of breast cell lines.
Supplementary Table S1 from Diverse Targets of β-Catenin during the Epithelial–Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse
Authors: Chang Yi-Wen , Su Ying-Jhen , Hsiao Michael , Wei Kuo-Chen , Lin Wei-Hsin , Liang Chi-Jung , Chen Shin-Cheh , Lee Jia-Lin
Published: March 2023

Supplementary Table S1: β-catenin ChIP-seq alignment results in LM cells
Supplementary Methods from The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis
Authors: Riesco-Eizaguirre Garcilaso , Wert-Lamas León , Perales-Patón Javier , Sastre-Perona Ana , Fernández Lara P. , Santisteban Pilar
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary Fig. S4 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: March 2023

Supplementary Fig. S4. miR-10b expression in primary tumors vs. lymph node metastases of mice implanted orthotopically with MDA-MB-231-luc-D3H2LN cells.
Supplemental Table S1 from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: March 2023

Supplemental Table S1. Clinical parameters, MCPyV status, and next-generation sequencing analyses
Supplemental Methods from Imaging Active Urokinase Plasminogen Activator in Prostate Cancer
Authors: LeBeau Aaron M. , Sevillano Natalia , Markham Kate , Winter Michael B. , Murphy Stephanie T. , Hostetter Daniel R. , West James , Lowman Henry , Craik Charles S. , VanBrocklin Henry F.
Published: March 2023

Supplemental Methods. Description of additional methods and procedures used in the study.
Supplementary Materials from Genetic Mutation of p53 and Suppression of the miR-17∼92 Cluster Are Synthetic Lethal in Non–Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling
Authors: Borkowski Robert , Du Liqin , Zhao Zhenze , McMillan Elizabeth , Kosti Adam , Yang Chin-Rang , Suraokar Milind , Wistuba Ignacio I. , Gazdar Adi F. , Minna John D. , White Michael A. , Pertsemlidis Alexander
Published: March 2023

Supplementary Materials. Supplementary tables, figure legends, figures, materials and methods.
Figure S1 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: March 2023

Figure S1. Characterization of P2X7R shRNA B16 cells. A, densitometry of P2X7R protein expression. B, representative Western blot. C, Fura-2 measurement of Benzoyl ATP (BzATP)-triggered intracellular Ca2+ increase. D, Averages intracellular Ca2+ increases in wt and P2X7R-silenced B16 cells. Data are averages + SEM, n = 5. ***, p < 0.001. E, rate of proliferation of wt and P2X7R-silenced B16 cell cultures. Intracellular Ca2+ changes and proliferation rates were measured as described in Adinolfi et al., 2005, Mol Biol Cell 16:3260-3272.
Table S6 from Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
Authors: Droog Marjolein , Nevedomskaya Ekaterina , Kim Yongsoo , Severson Tesa , Flach Koen D. , Opdam Mark , Schuurman Karianne , Gradowska Patrycja , Hauptmann Michael , Dackus Gwen , Hollema Harry , Mourits Marian J. , Nederlof Petra , van Boven Hester , Linn Sabine C. , Wessels Lodewyk , van Leeuwen Flora E. , Zwart Wilbert
Published: March 2023

ChIP-seq read count and mapped reads of endometrial tumors.
Supplementary Figure 6 from Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche
Authors: Giles Amber Jin , Reid Caitlin Marie , Evans Justin DeWayne , Murgai Meera , Vicioso Yorleny , Highfill Steven Lorenz , Kasai Miki , Vahdat Linda , Mackall Crystal Lee , Lyden David , Wexler Leonard , Kaplan Rosandra Natasha
Published: March 2023

Ex vivo tumor-mediated bone marrow expansion
Supplementary Figure 1 from Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche
Authors: Giles Amber Jin , Reid Caitlin Marie , Evans Justin DeWayne , Murgai Meera , Vicioso Yorleny , Highfill Steven Lorenz , Kasai Miki , Vahdat Linda , Mackall Crystal Lee , Lyden David , Wexler Leonard , Kaplan Rosandra Natasha
Published: March 2023

Growth and metastatic timeline of E0771 BCA and M3-9-M ERMS
Supplementary Figure S1 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: March 2023

Structure of SK-216
Supplementary Figures from Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers
Authors: Lawson Campbell D. , Fan Cheng , Mitin Natalia , Baker Nicole M. , George Samuel D. , Graham David M. , Perou Charles M. , Burridge Keith , Der Channing J. , Rossman Kent L.
Published: March 2023

Supplementary Figures S1-S4 Supplementary Figure S1 Western blots showing knockdown of ArhGAP11A or RacGAP1. Supplementary Figure S2 ArhGAP11A and RacGAP1 are both required for proliferation of HER2-enriched and luminal B breast cancer cell lines. Supplementary Figure S3 ArhGAP11A and RacGAP1 regulate cell spreading. Supplementary Figure S4 Constitutively active Rac1 and Cdc42 do not affect BLBC proliferation.
Supplementary information from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: March 2023

Supplementary methods and figure legends
Supplementary Figure S3 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: March 2023

MSH2 is downregulated and miR-21 is upregulated in HCV-related human hepatitis tissues.
Supplementary Figure S2 from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: March 2023

Generation of rabbit polyclonal anti-Eva1 antibodies.
Supplemetary Figure S6 from BPTF Depletion Enhances T-cell–Mediated Antitumor Immunity
Authors: Mayes Kimberly , Alkhatib Suehyb G. , Peterson Kristen , Alhazmi Aiman , Song Carolyn , Chan Vivian , Blevins Tana , Roberts Mark , Dumur Catherine I. , Wang Xiang-Yang , Landry Joseph W.
Published: March 2023

BPTF KD does not induce an interferon type I response and BPTF does occupy features other than promoters.
Supplementary Figure S1 from Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy
Authors: Biktasova Asel K. , Dudimah Duafalia F. , Uzhachenko Roman V. , Park Kyungho , Akhter Anwari , Arasada Rajeswara R. , Evans Jason V. , Novitskiy Sergey V. , Tchekneva Elena E. , Carbone David P. , Shanker Anil , Dikov Mikhail M.
Published: March 2023

Clustered DLL1 triggers Notch downstream target genes in cancer cells.
Supplementary figure 2 from Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma
Authors: Delgado-Calle Jesus , Anderson Judith , Cregor Meloney D. , Hiasa Masahiro , Chirgwin John M. , Carlesso Nadia , Yoneda Toshiyuki , Mohammad Khalid S. , Plotkin Lilian I. , Roodman G. David , Bellido Teresita
Published: March 2023

Supplementary figure 2. MM cells increase Rankl mRNA levels in osteocytes.
Supplementary Table S1 from Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1–MAPK Interaction
Authors: Jin Xin , Pan Yunqian , Wang Liguo , Ma Tao , Zhang Lizhi , Tang Amy H. , Billadeau Daniel D. , Wu Heshui , Huang Haojie
Published: March 2023

Sequences for primers used for shRNAs and RT-qPCR
Supplementary Table 5 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
Authors: Hsu Jessie Hao-Ru , Hubbell-Engler Benjamin , Adelmant Guillaume , Huang Jialiang , Joyce Cailin E. , Vazquez Francisca , Weir Barbara A. , Montgomery Philip , Tsherniak Aviad , Giacomelli Andrew O. , Perry Jennifer A. , Trowbridge Jennifer , Fujiwara Yuko , Cowley Glenn S. , Xie Huafeng , Kim Woojin , Novina Carl D. , Hahn William C. , Marto Jarrod A. , Orkin Stuart H.
Published: March 2023

GSEA analysis of gene dependencies that correlate with Prmt1 dependency in the human Project Achilles dataset.
Table S3 from DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer
Authors: Lulli Matteo , Del Coco Laura , Mello Tommaso , Sukowati Caecilia , Madiai Stefania , Gragnani Laura , Forte Paolo , Fanizzi Francesco Paolo , Mazzocca Antonio , Rombouts Krista , Galli Andrea , Carloni Vinicio
Published: March 2023

Table S3. % 13C enrichment in cell lysates for13C-alanine (mitochondrial pyruvate labeling) and 13C-lactate (cytosol pyruvate labeling) obtained by 1H NMR analysis.
Table S1 from DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer
Authors: Lulli Matteo , Del Coco Laura , Mello Tommaso , Sukowati Caecilia , Madiai Stefania , Gragnani Laura , Forte Paolo , Fanizzi Francesco Paolo , Mazzocca Antonio , Rombouts Krista , Galli Andrea , Carloni Vinicio
Published: March 2023

Table S1. Characteristics of the healthy subjects (HS) and patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC)
Supplementary Methods from DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer
Authors: Lulli Matteo , Del Coco Laura , Mello Tommaso , Sukowati Caecilia , Madiai Stefania , Gragnani Laura , Forte Paolo , Fanizzi Francesco Paolo , Mazzocca Antonio , Rombouts Krista , Galli Andrea , Carloni Vinicio
Published: March 2023

Description of supplementary methods
Supplementary Figure Legends from DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer
Authors: Lulli Matteo , Del Coco Laura , Mello Tommaso , Sukowati Caecilia , Madiai Stefania , Gragnani Laura , Forte Paolo , Fanizzi Francesco Paolo , Mazzocca Antonio , Rombouts Krista , Galli Andrea , Carloni Vinicio
Published: March 2023

Description of supplementary figures
Data from Chimeric NKG2D Receptor–Bearing T Cells as Immunotherapy for Ovarian Cancer
Authors: Barber Amorette , Zhang Tong , DeMars Leslie R. , Conejo-Garcia Jose , Roby Katherine F. , Sentman Charles L.
Published: March 2023

Abstract
Despite advancements in the treatment of ovarian cancer, this disease continues to be a leading cause of cancer death in women. Adoptive transfer of tumor-reactive T cells is a promising antitumor therapy for many cancers. We designed a chimeric receptor linking NKG2D, a natural killer (NK) cell–activating receptor, to the CD3ζ chain of the T-cell receptor to target ovarian tumor cells. Engagement of chimeric NKG2D receptors (chNKG2D) with ligands for NKG2D, which are commonly expressed on tumor cells, leads to T-cell secretion of proinflammatory cytokines and tumor cytotoxicity. In this study, we show that >80% of primary human ovarian cancer samples expressed ligands for NKG2D on the cell surface. The tumor samples expressed MHC class I–related protein A, MICB, and UL-16 binding proteins 1 and 3. ChNKG2D-expressing T cells lysed ovarian cancer cell lines. We show that T cells from ovarian cancer patients that express chNKG2D secreted proinflammatory cytokines when cultured with autologous tumor cells. In addition, we show that chNKG2D T cells can be used therapeutically in a murine model of ovarian cancer. These data indicate that treatment with chNKG2D-expressing T cells is a potential immunotherapy for ovarian cancer. [Cancer Res 2007;67(10):5003–8]
Data from Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel
Authors: Shen Lanlan , Kondo Yutaka , Ahmed Saira , Boumber Yanis , Konishi Kazuo , Guo Yi , Chen Xinli , Vilaythong Jill N. , Issa Jean-Pierre J.
Published: March 2023

Abstract
Aberrant promoter hypermethylation and associated gene silencing are epigenetic hallmarks of tumorigenesis. It has been suggested that aberrant DNA methylation can affect the sensitivity of cancers to antineoplastic agents by altering expression of genes critical to drug response. To study this issue, we used bisulfite PCR to assess DNA methylation of 32 promoter-associated CpG islands in human cancer cell lines from the National Cancer Institute (NCI) drug-screening panel (NCI-60 panel). The frequency of aberrant hypermethylation of these islands ranged from 2% to 81% in NCI-60 cancer cells, and provided a database that can be analyzed for the sensitivity to ≈30,000 drugs tested in this panel. By correlating drug activity with DNA methylation, we identified a list of methylation markers that predict sensitivity to chemotherapeutic drugs. Among them, hypermethylation of the p53 homologue p73 and associated gene silencing was strongly correlated with sensitivity to alkylating agents. We used small interfering RNA to down-regulate p73 expression in multiple cell lines, including the resistant cell lines TK10 (renal cancer) and SKMEL28 (melanoma). Down-regulating p73 substantially increased sensitivity to commonly used alkylating agents, including cisplatin, indicating that epigenetic silencing of p73 directly modulates drug sensitivity. Our results confirm that epigenetic profiles are useful in identifying molecular mediators for cancer drug sensitivity (pharmaco-epigenomics). [Cancer Res 2007;67(23):11335–43]