bluuebunny/crossref_metadata_2025 huggingface dataset:
DEPOPULATION IN PERIPHERAL REGIONS OF EASTERN POLAND – DETERMINANTS AND CONSEQUENCES
Authors: Ślusarz Grzegorz
Published: December 2021

The study examines demographic processes and the resulting challenges for the development of areas at risk of depopulation. The research covered regions defined as NUTS 2 in European Union nomenclature and classified as the Eastern Poland Macroregion in Polish regional policy. This macroregion is counted among the peripheral regions of Poland. The demographic processes taking place within these regions, and especially in many local administrative units (LAU 2), point to a threat of depopulation. The scope of the detailed study is from 2010 to 2020. Descriptive, tabular and graphical methods, as well as demographic projections until 2040 were used to analyse and present the materials for the analysed provinces. It was found that unfavourable demographic processes are intensifying and pose a threat to socio-economic development, especially for the peripheral rural communes of these regions. Progressing decline in fertility, increasing life expectancy, as well as intensified migration processes lead to unfavourable changes in the population structure, and, in the long run, to depopulation, which will undoubtedly multiply economic and social problems in these regions.
AN ASSESSMENT OF THE SELF-SUFFICIENCY LEVEL OF SELECTED COUNTRIES IN CENTRAL AND EASTERN EUROPE IN POULTRY MEAT PRODUCTION
Authors: Kubala Sebastian , Stanuch Marcin
Published: December 2021

One of the key markets of the European Union is the poultry meat market. The situation on this market is of significant importance to both producers and consumers. The main aim of the article is to study the level of self-sufficiency of selected countries in Central and Eastern Europe in the production of poultry meat. Eleven countries were selected as the research area: Bulgaria, Croatia, the Czech Republic, Estonia, Lithuania, Latvia, Poland, Romania, Slovakia, Slovenia and Hungary. In the conducted research, simplified indices of self-sufficiency were used: the balance of foreign trade in terms of volume and value, average annual consumption per capita and production volume in relation to consumption. The study was conducted for the years 2009-2018. The statistical sources used come from FAOSTAT and International Trade Centre databases. Research has shown that the analyzed countries are characterized by a significant diversification of the self-sufficiency level of poultry meat production. Only 6 analyzed countries can meet the domestic consumption demand from their own production, the remaining countries supplement the deficit from imported goods. The highest level of self-sufficiency of poultry meat production was observed in Poland, Slovenia, Lithuania and Hungary. On the other hand, the lowest level is found in Bulgaria, the Czech Republic, Estonia, Slovakia and Latvia.
Perceived Physical and Psychological Health in Middle Adulthood : Links to Marital Satisfaction, Age of Marriage, and SES
Authors: Uludağlı Nilay Pekel , Pekçetin Şeyda
Published: December 2021

Background: The life course health development approach, as a new theoretical model relating to health, dwells on psychosocial factors as well as biological factors, and it proposes that the effects of developmental timing unfolding over one’s lifespan should be considered. Based on this theoretical model, as well as empirical studies relating to marriage and health, one of the psychosocial factors that may contribute to the health of middle-aged individuals is the marital relationship. Aims: The aim of this study – conducted with individuals in middle adulthood – is to investigate the relationships between marital satisfaction, age at the time of marriage, SES (socioeconomic status) and psychological and physical health. Method: Data was collected from middle-aged individuals between 40–69 years in Turkey (160 women and 142 men). The World Health Organization Quality of Life Measurement Tool, Brief Symptom Inventory, Marriage Life Scale, and a Demographic Information Form were used to assess the participants’ perceived physical and psychological health, their marital satisfaction, their age of marriage, and SES. Results: A path analysis indicated that the age of marriage was positively related, and perceived psychological health problems were negatively related to perceived physical health. Both marital satisfaction and SES were negatively related to perceived psychological health problems. Upon examination of the mediator role of psychological health problems and SES, it was observed that both marital satisfaction and SES were related to perceived physical health through perceived psychological health problems. Also, the age of marriage was related to perceived psychological health problems via SES. Conclusion: The findings showed that marriage is an important component in the evaluation of perceived health in middle age; individuals are healthier when they get married at a more mature age and have a positive marital relationship.
Living in Cohousing Communities : Personality Traits and Trait Emotional Intelligence
Authors: Schetsche Christian , Jaume Luis Carlos , Gago-Galvagno Lucas , Elgier Angel Manuel
Published: December 2021

Cohousing communities are characterized by an increased amount of exchanges in social support. Since this circumstance could be attributed to certain characteristics of their inhabitants, the aim of this study was the evaluation of personality traits and trait emotional intelligence. To this purpose, a group difference study was performed in Germany between a sample of residents in cohousing communities (n = 180) and inhabitants of common neighborhoods (n = 104). Significant differences were found that support the idea that residents of cohousing communities have higher levels of well-being and minor levels of detachment and psychoticism, as well as a lower overall score for maladaptive personality traits. We have concluded that further research is needed to examine the possible causal relationships between these findings, and to verify whether living in a cohousing community can operate as a moderator of these traits or if their inhabitants had already bore them before moving into such communities.
Identification of Antibiotic-Resistant Genes and Effect of Garlic Ethanolic Extract on Mycobacterium tuberculosis Isolated from Patients in Zabol, Iran
Authors: Fazeli-Nasab Bahman , Valizadeh Moharram , Beigomi Maryam , Saeidi Saeide
Published: December 2021

Background: Mycobacterium is a genus of Actinobacteriaceae and the Mycobacterium family, including important pathogens, such as Mycobacterium tuberculosis (i.e., the cause of tuberculosis) and Mycobacterium leprae (i.e., the cause of leprosy). Tuberculosis is still a major cause of death in human societies. Objectives: The current study aimed to evaluate the effect of ethanolic extract of garlic on Mycobacterium tuberculosis isolated from patients in Zabol, Iran, and investigate the presence of antibiotic-resistant genes in Mycobacterium tuberculosis. Methods: Garlic (Allium sativum) was collected from Zabol, and the ethanolic extract of garlic leaf was obtained. In this study, 50 strains of Mycobacterium tuberculosis were obtained from the patients in Zabol. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. Some antibiotics, such as isoniazid, pyrazinamide, ethambutol, amikacin, streptomycin, and rifampicin, were used for positive control. Genomic deoxyribonucleic acid was extracted by the sodium dodecyl sulfate method. Furthermore, the presence of antibiotic-resistant genes, namely KatG, PncA, embC, embA1, embA2, embB1, embB2, rrs, rpsL, and ropB, in Mycobacterium tuberculosis was investigated using polymerase chain reaction. Results: The lowest MIC and MBC of garlic ethanolic extract against Mycobacterium tuberculosis were 3.25 and 7.5 ppm, respectively. The highest MIC and MBC were 60 and 120 ppm, respectively. Following the investigation of the presence of antibiotic-resistant genes in Mycobacterium tuberculosis, it was determined that it contains KatG, PncA, embC, embA1, embA2, ropB, rpsL, rrs, embB2, and embB1 genes. The highest resistance of Mycobacterium tuberculosis was against rifampin (81%) and then amikacin (76.6%) belonging to ropB and rrs genes, respectively. Conclusions: The results of the present study showed that the ethanolic extract of garlic was very effective in Mycobacterium tuberculosis and the most effective genes in mycobacteria were ropB and rrs. Although garlic is very effective in Mycobacterium tuberculosis, it is not recommended to directly use the results of this study. Therefore, it is required to perform clinical trials to confirm the results.
Thalassemia and COVID-19: Susceptibility and Severity
Authors: Rahimi Somayeh , Zakeri Saba , Nouri Mahsa , Mohassel Yaser , Karami Bahareh , Hosseini Jomor Seyedeh Ozra , Sayad Babak , Mohseni Afshar Zeinab , Rahimi Zohreh , Asadi Zahra
Published: December 2021

Context: COVID-19 results in an imbalance between procoagulant and anticoagulant homeostatic mechanisms that could be complicated with thrombotic events. In β-thalassemia patients, the presence of comorbidities, iron overload, adrenal hypofunction, splenectomy, and chronic hypercoagulable state might increase the susceptibility to COVID-19 and its severity. Evidence Acquisition: The search was conducted in PubMed, Web of Science, and Scopus databases for the key terms of β-thalassemia/thalassemia and COVID-19 until July 2021. Results: The survey of published observational studies (mostly multicenter and case reports) indicated a lower prevalence of COVID-19 in β-thalassemia patients compared with the general population, as well as mild to moderate COVID-19 in these patients, especially in those without comorbidity. β-Thalassemia children were susceptible to COVID-19 but with less severity compared to adults. There is no report of pulmonary embolism and thrombotic events in β-thalassemia patients with COVID-19; however, coagulation abnormality and pulmonary microembolism have been found in these patients. Conclusions: Findings could be interpreted by the presence of high hemoglobin F (HbF) levels, the advantage of hydroxyurea (HU) therapy, splenectomy, and iron chelation therapy in these patients. However, due to the low sample size and studying mainly young patients, the results should be interpreted with caution, and it still needs more studies with a larger sample size to confirm these findings.
Functionality of the system of information security in automated data processing systems in the conditions of external intrusions by analogy with the human immune system
Authors: Simavoryan Simon Zhorzhevich , Simonyan Arsen Rafikovich , Popov Georgii Aleksandrovich , Ulitina Elena Ivanovna
Published: December 2021

This article is dedicated to construction of the system of information security in automated data processing systems that function by analogy with the human immune system. The subject of this research is the development of the procedure for countering external intrusions of viruses, spam, and other destructive software programs in automated data processing systems. The object of this research is the systems of ensuring information security in automated data processing systems and human immune system. Methodological research on elaboration of the procedure for identification of intrusion is conducted via methods of artificial intelligence, systemic analysis, theory of neural and immune systems in the sphere of ensuring information security based on the achievements of systemic analysis and a systemic-conceptual approach towards information security in automated data processing systems. The main result lies in the developed general procedure for the functionality of the system of ensuring information security in countering external intrusions in the form of block-diagram and its description. The procedure is based on the idea of similarity in functionality of the mechanisms and procedures for protection against external intrusions in both, human immune system and automated data processing system, as well as drawing parallel between them. The main peculiarity of the developed procedure lies in its applicability to the accepted classification of the initial external environment of intrusion onto physical, information, field, and infrastructure environments. Such approach guarantees the novelty of the development from the perspective of constant updating of human immune system countering mechanisms to the external intrusions and its application for each environment in applicable to automated data processing systems.
Symbolism in the English and Russian fairy tale folklore: comparative analysis
Authors: Vavilova Kseniya Yur'evna
Published: December 2021

The subject of this research is the symbolism in the English and Russian fairytale tradition. The object is the texts of the Russian and English fairy tales. Analysis of the texts reveals the typical functions performed by symbols in both folklore traditions. The author provides the examples of symbols and offers the interpretation of objects-symbols, symbols-zoonyms, color and number symbols, time and space symbols. Comparative study of folklore heritage of non-cognate languages reveals the fundamental commonness of a particular folk genre of different peoples in their perspective upon reality, methods of depiction, and ideological interpretations. The scientific novelty consists in conclusions obtained in the comparative study of the symbolism of fairy tale texts in the Russian and British folklore, which is important for determination of linguistic, semiological and cultural universals. The comparative study of folklore material of two traditions in the sphere of the poetics of folklore reveals the traditional universals and unique features on the level of symbolism of the fairy tale genre. Within the framework of the article, the author analyzes the functionality of thematic, animalistic, color, spatial-temporal, and numerical symbols. The acquired results are underpinned by a large number of text examples.
Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes
Authors: Trembley Janeen H. , Li Bin , Kren Betsy T. , Peltola Justin , Manivel Juan , Meyyappan Devi , Gravely Amy , Klein Mark , Ahmed Khalil , Caicedo-Granados Emiro
Published: December 2021

Background

Oropharyngeal squamous cell carcinoma (OPSCC) incidence is rising worldwide, especially human papillomavirus (HPV)-associated disease. Historically, high levels of protein kinase CK2 were linked with poor outcomes in head and neck squamous cell carcinoma (HNSCC), without consideration of HPV status. This retrospective study examined tumor CK2α protein expression levels and related clinical outcomes in a cohort of Veteran OPSCC patient tumors which were determined to be predominantly HPV(+).

Methods

Patients at the Minneapolis VA Health Care System with newly diagnosed primary OPSCC from January 2005 to December 2015 were identified. A total of 119 OPSCC patient tumors were stained for CK2α, p16 and Ki-67 proteins and E6/E7 RNA. CK2α protein levels in tumors and correlations with HPV status and Ki-67 index were assessed. Overall survival (OS) analysis was performed stratified by CK2α protein score and separately by HPV status, followed by Cox regression controlling for smoking status. To strengthen the limited HPV(−) data, survival analysis for HPV(−) HNSCC patients in the publicly available The Cancer Genome Atlas (TCGA) PanCancer RNA-seq dataset was determined for CSNK2A1.

Results

The patients in the study population were all male and had a predominant history of tobacco and alcohol use. This cohort comprised 84 HPV(+) and 35 HPV(−) tumors. CK2α levels were higher in HPV(+) tumors compared to HPV(−) tumors. Higher CK2α scores positively correlated with higher Ki-67 index. OS improved with increasing CK2α score and separately OS was significantly better for those with HPV(+) as opposed to HPV(−) OPSCC. Both remained significant after controlling for smoking status. High CSNK2A1 mRNA levels from TCGA data associated with worse patient survival in HPV(−) HNSCC.

Conclusions

High CK2α protein levels are detected in HPV(+) OPSCC tumors and demonstrate an unexpected association with improved survival in a strongly HPV(+) OPSCC cohort. Worse survival outcomes for high CSNK2A1 mRNA levels in HPV(−) HNSCC are consistent with historical data. Given these surprising findings and the rising incidence of HPV(+) OPSCC, further study is needed to understand the biological roles of CK2 in HPV(+) and HPV(−) HNSCC and the potential utility for therapeutic targeting of CK2 in these two disease states.
Epidural Ropivacaine and Dexmedetomidine with that of Epidural Ropivacaine and Fentanyl for Postoperative Analgesia in Lumbar Spine Surgeries- A Randomised Double-Blinded Study
Authors: Prashanth G , Dash Sulochana , Mohapatra Sudeep , Moda Nupur
Published: December 2021

Introduction: Epidural with opioids as adjuvants are the most common agents of choice for postoperative analgesia in spine surgeries which promote early ambulation, increased patient satisfaction and improved outcome. Recently, epidural administration of α2 agonists in combination with local anaesthetics in low doses offers new dimensions in the management of postoperative pain. Aim: To compare the analgesic efficacy, sedation score and haemodynamic stability of Epidural Ropivacaine and Fentanyl (RF) with that of Ropivacaine and Dexmedetomidine (RD) in the postoperative period in lumbar spine surgeries. Materials and Methods: This was a randomised, double-blinded study conducted on 120 patients at IMS and SUM Hospital, Bhubaneswar, Khordha, India. Haemodynamic parameters, Visual Analogue Score (VAS), sedation score, time to 1st dose of rescue analgesics requirement and complications were observed. The study consisted of group RF that received ropivacaine and fentanyl and group RD that received ropivacaine and dexmedetomidine, with 60 patients in each group. Continuous variables were analysed with the unpaired t-test and categorical variables were analysed with Chi-square Test and Fisher-Exact test. Statistical significance was taken as p <0.05 Results:ThemeanageofparticipantsingroupRDwas39.73±7.192 years and in group RF was 40.67±7.434 years (p-value 0.872). Heart rate was in lower range in RD group throughout the study and was statistically significant with a p-value <0.05. VAS score was lower, sedation score was higher and time to 1st dose of rescue analgesia were longer in RD group compared to group RF (p<0.005). Complications like hypotension (33.3%), bradycardia (20%) were more common in group RD while nausea, vomiting (16.67%) and pruritis (10%) were noted in group RF. Conclusion: Dexmedetomidine seems to be a better neuraxial adjuvant with good postoperative analgesic efficacy, better patient comfort and hemodynamic stability compared with that of fentanyl.
Multi-layer Budding of Oversized Rubber (Hevea brasiliences) Seedlings: Success and Growth in Different Soil Media
Authors: Onofre S. Corpuz, , Guiamal K. U.
Published: December 2021

The study on Multi-layer budding of oversized rubber seedling aimed at evaluating the success of multiple budding operation on single seedling of rubber tree species comprising of 4 to 7 budding layers per seedling. The experiment used randomized complete blocked design layout with 3 treatments such as 4, 5 and 7 layer budding in a single seedling replicated 4 times. Results revealed that the highest number of budding layers succeeded significantly higher as compared to 4 and 5 layers. The main survival percentage is about 79.17% for the 7 layers, 76.52% for the 5 layers and only about 55.36% for the 4 layers. Pure garden soil reported to have significant results on sprouting rate, sprout length, stalk diameter and number of leaves. This finding emphasized that budding of rejected oversized rubber seedlings grown in an abandoned nurseries can be reutilized for mass production of budded cuttings through multiple budding of 7 layers per seedlings to maximize planting materials derived from single seedlings.
Profile Analysis of Tribal Farmers of Vidarbha Region
Authors: Gandhale A. A. , Tekale V. S.
Published: December 2021

In Maharashtra 10.33 million population belonged to tribal’s. Tribal people constitute the most deprived and neglected section of the population of the state, hence the research objective was formulated to study the profile of tribal farmers of Vidarbha region. An exploratory research design of social science was used for the present investigation. Study was conducted in Gadchiroli and Yavatmal districts in the year 2020, with 280 respondents. The findings suggested that, relatively high per cent (44.28%) of the respondents were belonged to middle age (36 to 50 years) group category, more than one fourth (29.30%) of the respondents were educated up to primary school level, nearly half (48.92%) of the respondents concentrated in medium size of family with 5 to 6 members in the family, majority (54.64%) of the respondent tribal farmers were belonged to nuclear type of family, relatively high per cent of the respondents (46.43%) involved in agriculture, majority of the respondent tribal farmers (72.14%) had annual earning up to Rs. 80,000/-, more than half (51.78%) of the respondents had small size of land holding (1.01 to 2.00 ha.), majority (52.85%) of the respondents had medium (24 to 43 years) farming experience, majority (71.43%) of the respondents had medium level of social participation, majority (73.92%)  of the respondents were using medium level of sources of information, majority (54.64%) of the respondent tribal farmers belonged to medium innovativeness category, majority (63.92%) of the respondents had medium cosmopolitness in nature, majority (75.71%) of the respondent tribal farmers had medium level of change orientation, whereas 56.07 per cent had medium level of fatalism, more than three fourth of the respondents (78.21%) had derived medium level of benefits.
Effect of Climate Change on Drinking Water Utilities in Nzoia River Basin, Kenya
Authors: Odwori Ernest Othieno
Published: December 2021

Climate change is already having noticeable effects on water utilities in Nzoia River Basin. Extreme weather and climate-related occurrences are becoming more common and intense, as predicted by the Intergovernmental Panel on Climate Change (IPCC), Third Assessment Report. Because most water utilities are unprepared, the repercussions might be severe. The water supply infrastructure is built for resiliency and sustainability of operations during weather events or other circumstances that could potentially interrupt services; but when events that were historically considered to be “100-year” events happen more and more frequently, utilities must prepare for a new normal. These extreme events are occurring or being exceeded more regularly, and as a result, the past may no longer be a reliable predictor of the future. In Nzoia River Basin, the water supply infrastructure currently designed for historical climate conditions is more vulnerable to future weather extremes and climate change. This study assessed the effect of climate change on drinking water utilities in Nzoia River Basin. A cross-sectional survey design was used. Three counties were randomly selected from the basin for study with Busia representing the lower catchment, Kakamega middle catchment and Trans Nzoia upper catchment. The study was carried out from May, 2017 to September, 2017. In-depth expert interviews and brainstorming sessions were used to identify the climate change impacts affecting drinking water utilities experienced in the last ten years in the basin. A carefully selected team of water and climate change experts consisting of decision makers, practitioners, managers, scientists and technology adopters were used to rank the severity of the climate change impacts. Climate change occurring in Nzoia River Basin is expected to have a wide range of consequences for drinking water utilities. By assessing its potential impacts on water utilities, we become better positioned to make improvements today to decrease the future risks. The results of this study provide valuable insights for the national and county governments in preparing to effectively anticipate and respond to the relevant issues that they can expect to face in the coming century.
Analysis of Students' Mathematical Reasoning Ability with the Constructivism Approach through Mobile Learning System
Authors: Wahyuni Yusri , Jamaris .
Published: December 2021

Aims: To analyze the mathematical reasoning ability of mathematics education students.

Study Design: Qualitative research with a descriptive approach.

Place and Duration of Study: The population of all 3rd-semester mathematics education students at Bung Hatta University who take geometry courses is 25 students.

Methodology: This research is qualitative research with a descriptive approach. Researchers directly measure the mathematical reasoning ability of students in the mathematics education study program. Judging from the research subjects, the population of all 3rd-semester mathematics education students at Bung Hatta University who took geometry courses was 25 students.

Results: From the analysis results, it was found that the achievement of mathematical reasoning abilities for indicators of students' ability to present mathematical statements orally, in writing, pictures, and diagrams indicated by question number 1 was 74% (Good Category). The indicators of mathematical manipulation ability shown in questions number 2 and 5 are 41% (Category Enough), and 42% (Category Enough). And the indicators of students' ability to conclude, compile evidence, provide comments, or evidence from several solutions shown by questions number 3 and 4 are 67% (Good Category) and 58% (Enough Category).

Conclusion: The conclusion of this study is to be able to determine the category of mathematical reasoning of the 3rd-semester students of the Bung Hatta University Mathematics Education Study Program.
Aqueous Extract of Alstonia boonei Bark Reduces Chronic Hyperglycemia and Prevents its Complications through Increase of Hepatic Global Dna Methylation in Diabetic Wistar Rats
Authors: Fonkoua Martin , Arnold W. Tazon , Ntentié R. Françoise , Kingue B. Azantsa , Nguemto G. Takuissu , Judith L. Ngondi , Enyong J. Oben
Published: December 2021

Aim:  DNA methylation profile is involved in several physiological processes. Its alterations in the liver of diabetic patients characterized by global hypomethylation are associated with the pathophysiology of type 2 diabetes and its complications. The present study has evaluated the effect of the aqueous extract of Alstonia boonei barks on the global methylation of hepatic DNA in association with hyperglycemia and diabetes complications induced by high-fat diet (HFD) feeding and administering of streptozotocin (STZ) which mimics the metabolic abnormalities very similar to those seen in human Type 2 diabetes.

Methods: A. boonei barks were harvested, processed, dried, ground and an aqueous extraction was prepared (ratio 1/10 w/v). An in vivo study was conducted in an animal model of high-fat-streptozotocin (HF-STZ) induced diabetes. Rats were divided into five groups of five rats each: a normoglycemic group, an untreated hyperglycemic group, three hyperglycemic groups including two test groups receiving aqueous extract of A. boonei barks (AEAB) by esophageal gavage at the doses of 200 and 400 mg/kg body weight once daily and a reference group receiving metformin at 10 mg/kg body weight. After 28 days of experimentation during which fasting blood glucose levels were taken every 14 days under fasting conditions, the animals were sacrificed. Plasma and liver homogenate samples from the sacrificed rats were used for biochemical assays (markers of oxidative stress such as malondialdehyde level, superoxide dismutase (SOD) and catalase activity, and markers of lipid profile such as total cholesterol, and triglycerides, HDL-c, LDL-c and VLDL-c).  The analysis of the global DNA methylation profile was performed by the immunoprecipitation. Pearson's correlation was used to evaluate the relationship between the values.

Results: The aqueous extract increased the hepatic DNA methylation by 0.41% and 0.63% at 200 and 400 mg/kg body weight, respectively, compared to metformin (0.47%±0, 05). This effect was significantly associated with the hypoglycemic effect obtained at 400 mg/kg body weight with a decrease in initial blood glucose level of -29.87%.

Conclusion: AEAB reduces chronic hyperglycemia and prevents its complications by increasing global hepatic DNA methylation.
Assessment of Factors that Limit Optimal Use of Organic Fertilizers in Subsistence Food Production in Vihiga County, Kenya
Authors: J. Kipsat Mary , Osewe D. O. , Bwari Mose Phoebe
Published: December 2021

In the face of skyrocketing prices of inorganic fertilizers, organic materials are considered the alternative sources of fertilizers. Research institutions have over the years succeeded in demonstrating high yield responses to recommended usage of organic fertilizers. Furthermore, organic fertilizer (biofertilizers) is a vital component of sustainable agriculture. The sound management of organic fertilization must attempt to ensure both an enhanced and safeguarded environment. Most Farmers in Vihiga County have adopted use of organic fertilizers. Despite this, crop yields remain low in farmers’ fields due to low soil fertility and inability of farmers to optimally use organic fertilizers. Researchers often use optimal organic materials recording high yields in experimental and farm demonstration fields. Little or no research has been done to determine why farmers still record low yields despite a lot of extension outreaches to promote available organic matter technology packages in the study area. This paper reports findings of a study carried out to determine factors that limit optimal use of organic fertilizer by farmers in Vihiga County, Kenya. The objective of the study was to compare organic fertilizer usage in farmers’ field with optimal (recommended) rates to determine if the usage were significantly different. This was aimed at providing advice based on empirical evidence to farmers on whether there is need to improve usages of organic fertilizer and to determine if low intensity of organic fertilizer was a possible cause of recorded low yields in farmers’ fields. Purposive sampling was used to select farmers who were using organic fertilizer for soil fertility. A total of 120 farmers were selected to provide data needed for the study. Primary data was collected using questionnaires and data was analyzed using descriptive statistic (t-test). The results of the analysis indicated a significant difference in the usage between what farmers applied and what was recommended by research. Usages of organic fertilizer among the sampled farmers were much lower than the recommended levels explaining the low maize yields among farmers in the study area. The study rejected the hypothesis that the farmers’ usages of organic fertilizer was not statistically significant different from that recommended by research institutions. This is because average usage of organic fertilizer of 320.3 kg/ha was significantly below those recommended by researcher of 5ton/ha (at 99% usage. Farmers must follow appropriate promoted technology recommendations. The study recommended promotion of organic fertilizer. Farmers should be sensitized on the need to bridge the gap between the current and the recommended usage for them to realize the benefits of organic fertilizer.
Influence of Nutrient Concentration on Growth, Yield And Quality of Spinach (Spinacia oleracea L.) in Hydroponic System
Authors: Sutnga Baiamonlangki , Bahadur Vijay , Kerketta Anita
Published: December 2021

The present experiment entitled “Influence of nutrient concentration on Growth, Yield and Quality of Spinach (Spinacia oleracea L.) in Hydroponic system” was carried out in Shade net, Research Field, Department of Horticulture, SHUATS, Prayagraj during  March- April,2020.. The experiment was laid out in complete randomized design (CRD), with eight treatments, replicated thrice with nutrient field technique hydroponics system and variety Mulayam of Spinach, the treatments were T1 (NPK 6.25 ml/plant), T2 (NPK 8.33 ml/plant), T3 (NPK 10.41 ml/plant), T4 (NPK 12.5 ml/plant), T5 (NPK 14.58 ml/plant), T6 (NPK 16.66 ml/plant), T7 (NPK 18.75 ml/plant) and T0 (NPK 0 ml/plant). From the present experimental findings, it is found that structure with treatment T4 was found best in terms of Growth and yield parameters of spinach in NFT hydroponic system followed by structure with T3 and T1 due to appropriate supply of plant nutrients and the water treated plants had the lowest values. Maximum gross return (1871.30Rs) and net return (746.30 Rs) and maximum benefit cost ratio (1.66) was also observed in treatment T4. As seen from the experiment, it was observed that the treatment T4 was ideal nutrient for Spinach good growth and yield. Therefore, an ideal nutrient concentration helps the plants in good growth and yield.
Synergistic Effect of Docetaxel Plus Saponin Fraction of Vitex doniana on Prostate Specific Antigen and p53 in Nitrsobis (2-oxopropyl) Amine-induced Prostate Toxicity
Authors: Abireh Ifeanacho Ezeteonu , Anyanwu Godson Emeka
Published: December 2021

Aim: This study investigated the synergistic effect of docetaxel plus saponin fraction of Vitex doniana on prostate specific antigen and p53 in nitrsobis (2-oxopropyl) amine-induced prostate toxicity in Wistar rat.

Methodology: Twenty-four (24) male Wistar rats with elevated serum prostate specific antigen level were selected from a group of sixty (60) rats pretreated with subcutaneous Nitrosobis (2-oxopropyl) amine 5 mg/kg daily for 4 weeks. The selected 24 male Wistar rats were then grouped into 6 groups of four (4) rats each. Group 1 was given 1ml normal saline daily from day 1-28. Groups 2, 3, 4, 5, and 6 further received subcutaneous nitrosobis (2-oxopropyl) amine 5 mg/kg daily from day 1-28. In addition, groups 3, 4, 5, and 6 were given weekly intravenous docetaxel 8 mg/kg on day 15 and 22. In addition to docetaxel, groups 4, 5, and 6 were further treated with oral saponin at 250 mg/kg, 500 mg/kg, and 750 mg/kg, respectively, daily, from day 15-28. Immunoenzymometric assay method was used for analysis of blood sample for prostate specific antigen. The prostate tissues were subjected to immuno study using the ImmunoCruz Staining System (Lab Vision Corporation, Fremont, CA, USA). The quantitative evaluation of p53 was done by calculating the percentages of p53-immunostained nuclei (labeling index).

Results: Significant increase in prostate specific antigen and p53 expression were observed in group 2 (treated with Nitrsobis (2-oxopropyl) amine alone) when compared with group 1 (control). Dose dependent decrease in prostate specific antigen and p53 expression were observed in groups 4, 5, and 6, treated with docetaxel 8 mg/kg plus 250 mg/kg, 500 mg/kg, and 750 mg/kg of saponin respectively.

Conclusion: Docetaxel plus Saponin fraction of Vitex doniana significantly reduced the serum prostate specific antigen concentration and p53 expression in a dose dependent manner, with the group treated with 750 mg/kg showing the highest decrease in the parameters tested.
Impact of Placenta Previa on Fetal Growth
Authors: Elrewany Hassan Abubakr , El Namori Mohamed Mohsen , Elshourbagy Shahinaz Hamdy , Awarah Ahmed Mahmoud
Published: December 2021

Background: Placenta Previa refers to the presence of placental tissue that extends over the internal cervical is during pregnancy. The incidence of this condition is reported to be 2% at 20 weeks of gestation and decreases to around 4–6 per 1000 births between 34 and 39 weeks through trophotropism. The aim of the work is to evaluate fetal growth in pregnancies complicated by placenta Previa.

Methods: This cross-sectional study was done on 100 pregnant females with placenta Previa aged 18-35 years. Cases were defined as patients with gestational age 24-40 weeks, BMI 18-30 kg/m2, Singleton fetus and diagnosed having placenta Previa; confirmed by trans-vaginal ultrasound in the second and third trimester. Complete history, vital signs and complete obstetric examination, laboratory and radiological investigations (ultrasound done trans-abdominally to evaluate fetal weight, biometry and Doppler studies) were taken.

Results: The gestational age ranged from 34-39 weeks with a mean value 36.03 ± 1.23 weeks and a median value 36 weeks (IQR = 35-37 weeks). The femur length ranged from 33.14-39.14 weeks with a mean value 35.44 ± 1.56 weeks and a median value 35.14 weeks (IQR = 34-36.9 weeks).The abdominal circumference ranged from 32.86-39.14 weeks with a mean value 35.43 ± 1.65 weeks with a median value 35.14 weeks (IQR = 33.9-36.7 weeks).

As regard to umbilical (UA) and middle cerebral (MCA) arteries Doppler resistant index (RI), UA ranged from 0.48-0.58 with a mean value 0.53 ± 0.03 and a median value 0.53 (IQR = 0.51-0.55). MCA ranged from 0.75-0.85 with a mean value 0.80 ± 0.03 and a median value 0.79 (IQR = 0.77-0.82).

Conclusion: Placenta Previa led to preterm delivery (<36 weeks) in about one third of the study cases. Femur length was <36 weeks in 65 patients. Abdominal circumference was <36 weeks in 61 patients. Placenta Previa had insignificant effect on umbilical (UA) and middle cerebral arteries Doppler resistant index.
A Prospective Observational Study on Diabetic Induced Complications and their Prone towards Surgery
Authors: Chetty C. Madhusudhana , Mabichan K. , Sandhya H. Raga , Mallikarjuna K.
Published: December 2021

Background: This study was mainly aimed to find out the diabetic complications that had been lead to surgey. The Diabetes mellitus describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate,fat and protein metabolism resulting from defects in insulin secretion,insulin action, or both.The effects of diabetes mellitus include long-term damage,dysfunction and failure of various organs.

Materials and Methods: A prospective observational study was conducted in the Santhiram college & general hospital for 6 months (December 2020 – May 2021)to assess the macro vascular and micro vascular complications of diabetes mellitus and prone to surgery of diabetic complications by using case sheets, prescriptions in tertiary care teaching hospital.

Results: A total of 150 patients are included in this study.In patients with diabetic complications we have observed: Diabetic ulcer with cellulitis in 19, gangrene in 19, peripheral vascular disease in 6, gangrene with cellulitis in 11,Non healing diabetes foot ulcer in 35, Coronary artery disease 24, diabetic retinopathy 25, MI in 11 patients.Among all complications, non healing diabetic foot was observed to be more when compared to other diabetic complications.In the study performed in diabetic induced complications of patients, debridement was performed in 30% patients, Amputation were performed in 13%, skin grating was performed in 13% patients, Angioplasty were performed in 23% patients and lasix surgery performed in 13% patients.

Conclusion: In our study we conclude that out of 150 cases, male patients are more prone to diabetic complications than females.The patient counselling should involve in minimizing the incidence and prevalence of diabetes by conducting the continuing health education and other health programms.
Effective Treatment of a Post-renal Transplantation Patient with Early Recurrent Focal Segmental Glomerulosclerosis and Concomitant Hemolytic Uremic Syndrome, a Case Report
Authors: Alsawadi Abdullah , Aloufi Majed , Fatta Ahmed , Almowaina Sahar , Elami Mugahid , Albahili Hamad , Zahid Rafat , Alyami Ali
Published: December 2021

While recurrence of primary Focal Segmental Glomerular Sclerosis (FSGS) is common post renal transplantation (30%-80%), a concomitant presentation of hemolytic uremic syndrome (HUS) and recurrent FSGS has never been reported. In addition, treatment of recurrent FSGS and HUS post-renal transplantation is challenging; and usually individualized based on center's experience. Here, we reported a case of a pediatric patient with early recurrence of FSGS and concomitant HUS post-renal transplantation. This patient had a complete hematological and renal response following the administration of Eculizumab and Rituximab, respectively. Withdrawal of Tacrolimus as well as plasmapheresis did not improve kidney function. Therefore, we concluded that both Eculizumab and Rituximab could achieve remission in comparable cases when administered at fixed intervals.
Barringtonia asiatica Seed Extract Induces G1 Cell Cycle Arrest in Saccharomyces cerevisiae and Exhibits Cytotoxicity in A2780 Human Ovarian Cancer Cells
Authors: Villanueva Nilita Sirikit P. , Vicera Carmela Vannette B. , Leonida Sheeny Fane L. , Paderog Melissa June , Sabido Edna M. , Saludes Jonel P. , Dalisay Doralyn S.
Published: December 2021

Barringtonia asiatica, is traditionally used as a medicinal plant in the Philippines; unfortunately, there is limited evidence supporting its anticancer capability. Thus, our study investigated the cytotoxic effect of B. asiatica seed extract against ovarian carcinoma A2780 (ECACC 93112519) and Saccharomyces cerevisiae as a cancer model organism. Seeds of B. asiatica were freeze-dried and extracted with methanol. The seed extract was investigated for its effect on the cell cycle in S. cerevisiae by utilizing yeast budding experiment and imaging flow cytometry. Its cytotoxicity activity was also tested as well as a live/dead assay was conducted against ovarian cancer cells. Findings revealed the anticancer activity of B. asiatica and its capability to induce G1 cell cycle arrest in S. cerevisiae. Thus, B. asiatica seeds may serve as a potential source of natural compounds towards anticancer drug discovery.
Phytochemicals against COVID -19, Pharmacological Perspectives: A Systematic Review
Authors: Ali Ahmed S. , Saied Ekram A. , Theeban Sharifa M. , Humayran Mazen M. , Shaker Assmaa Ahmed , Alfadil Abdelbagi , Almuhayawi Mohammed S.
Published: December 2021

Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited.

Objectives: To explore the pharmacological profile of specified compounds against COVID-19

Method: Systematic literature search of academic databases to explore specified phytochemicals for the management of COVID-19 using appropriate search terms. Rayyan software was used to organize 786 citations of which. 236 articles were included in this review.

Results: Initially 70 compounds were identified to have a potential role in the management of COVID-19. In this review, 18 compounds were selected for further search

Conclusion: In vitro anti-SARS-CoV-2activity has been demonstrated for a variety of natural compounds. However, preclinical research for most phytochemicals is scarce, and only a few compounds have been evaluated in clinical trials against COVID-19. A comprehensive pharmacological profile of these phytochemicals is urgently needed.
Challenges Faced by Healthcare Professionals during the COVID-19 Pandemic: A Review
Authors: Wankhede Pratibha , Wanjari Mayur , Late Sampada , Rodge Hina
Published: December 2021

Introduction: On March 11, 2020, the WHO formally declared the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks a pandemic by publishing public health guidelines to guide pandemic response. Serious illnesses may necessitate hospitalization and ventilatory assistance. The pandemic of coronavirus disease 2019 (COVID-19) has posed new concerns for healthcare workers around the world. However, in many developing nations, including India, information is scarce concerning these issues. Healthcare facilities are one-of-a-kind and difficult to understand. The Indian healthcare system consists of both governmental and private healthcare facilities. Healthcare practitioners face a variety of obstacles daily. The unexpected appearance of COVID-19 created a new threat to an already overburdened healthcare system. The pandemic altered the healthcare dilemma by introducing new employment and societal obstacles to healthcare workers. The goal of this review research is to uncover the causes of the workplace and societal issues that healthcare workers encounter.
Orchids as Valuable Folklore Medicine: A Review
Authors: Sushma . , Diksha Reenaand
Published: December 2021

The impetus of writing this paper is to review various medicinal orchid species growing in different parts of India. The family orchidaceae is one of the diverse groups among angiosperms which includes different types of orchid species. This paper is written to review the medicinal and therapeutic importance and use of different orchid species for treatment of various types of diseases. Orchids are herbaceous plants which are mentioned in ancient ayurvedic system of medicine because of their therapeutic properties. Most of the medicinal orchid species are epiphytic and terrestrial in habitat.
Effect of Ayurvedic Interventions on Toxemia of Pregnancy (Preeclampsia) & Fetal Outcome- A Randomized Placebo-Controlled Trial
Authors: Rathi Renu , Sharma Geeta , Sastry C. H. S , Kumar Abhimanyu , Verma Jitesh , Rathi Bharat , Khedekar Sumod
Published: December 2021

Background: Toxemia of pregnancy also known as preeclampsia is a common clinical condition affecting 8-10% pregnancies worldwide. It has adverse outcome both for mother and fetus. The management options are mainly targeted to prevent adverse outcomes associated to                premature births, such as administration of antenatal corticosteroids and magnesium sulphate infusions.

Aim & Objectives: The main aim of the study was to evaluate efficacy of Ayurvedic interventions in management of toxemia and in prevention of premature delivery as well as fetal hazards due to pre-eclampsia.

Methods: It was an open ended, parallel group, randomized placebo controlled clinical trial with equal allocation in both the groups. Sample size was 15 in each group. Trial group was administered Gokshura Siddha Yavagu(Green gram gruel medicated with Tribulus terrestris Linn) and Dhatryavaleha (linctus prepared with Ayurveda medicines like Phyllanthus emblica L.)while control group was treated with similar looking placebo-linctus.

Results: Both ayurvedic parameters-Shotha(edema), Avil mutrata (Discolored urine) & clinical features of toxemia have shown excellent relief while control group patients either show poor or no relief when assessed by USG scan and needed further treatment with induction of labor.

Conclusion: This study concludes that Ayurvedic interventions in the form of Gokshura siddha Yavagu and Dhatri Avleha can provide significant symptomatic relief (p<0.0001) in toxemia of pregnancy and can also promote normal growth and development in fetus.
Formulation Development and Characterization of Darunavir and Ritonavir Sustained Release Tablets Using Quality by Design Approach
Authors: Patel Dhaval , Patel Hitesh , Chaudhary Hiren
Published: December 2021

Darunavir is a nonpeptidic inhibitor of protease and is primarily metabolized by cytochrome P450 3A (CYP3A) isoenzymes. It is usually coadministered with low-dose ritonavir (Darunavir/r). Ritonavir is an inhibitor of CYP3A isoenzymes and pharmacologically enhances Darunavir which leads to increased plasma concentrations of darunavir and allows for daily lower dose. Here, we have developed combination SR formulation of Darunavir and Ritonavir and evaluated. In vitro drug release of all formulations was carried out in dissolution medium 900ml of pH 3.0, 0.05 M Sodium Phosphate Buffer + 2% Tween 20 for 75 RPM USP II apparatus (paddle). The results shown that, all the formulations of matrix tablets shown the good release of drug from trialed formulations however all formulations were not releasing the drug in enough amount. In matrix tablets F6, the release of drug shows NLT 80%. So, the formulation F6 have been considered as suitable for the SR tablet of Darunavir and Ritonavir. Tablets were also evaluated though Quality by Design (QbD) method.