bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating optimal learning moments in U.S. and finnish science classes
Authors: Schneider Barbara , Krajcik Joseph , Lavonen Jari , Salmela‐Aro Katariina , Broda Michael , Spicer Justina , Bruner Justin , Moeller Julia , Linnansaari Janna , Juuti Kalle , Viljaranta Jaana
Published: December 2015

This study explores how often students are engaged in their science classes and their affective states during these times, using an innovative methodology that records these experiences in situ. Sampling a subset of high schools in the U.S. and Finland, we collected over 7,000 momentary responses from 344 students over the course of a week. We examine engagement within and between students in different environments identifying common social and emotional factors they may be experiencing in their science classes, suggesting the challenges that the U.S. and Finland may encounter when implementing their new science standards (i.e., Next Generation of Science Standards and Finnish National Core Curriculum). We operationalize engagement as situational when students experience high levels of challenge, skill, and interest, which we term as optimal learning moments. Specifically we analyze: (i) the components of optimal learning; (ii) the relationship of optimal learning with other subjective measures; (iii) how optimal learning moments in science classes compare to other academic classes; and (iv) the extent that optimal learning moments predict an individual's perception of importance to self and future in science classes. Using several multivariate models, results show that when students are challenged in their classes and are appropriately skilled they are more likely to feel confident, successful, and happy during specific science classes as well as in other academic classes. When students experience more times of optimal learning in their science classes they are more likely to report that they perceive science as important to them and their futures. Females, however, report being more stressed in their science classes than males. © 2015 Wiley Periodicals, Inc. J Res Sci Teach 53:400–421, 2016
Water security in small island developing states: the limited utility of evolving governance paradigms
Authors: Belmar Yasa N. , McNamara Karen E. , Morrison Tiffany H.
Published: December 2015

Despite decades of donor support for the water sector, many small island developing states (SIDS) have failed to make acceptable levels of progress toward achievement of water‐related millennium development goals and reduction of water‐related risks. At least three distinct policy paradigms have at different times been regarded as best practice for responding to water insecurity throughout the world. Yet, while the water management literature points to the need for a paradigm shift toward improved governance approaches, there has been little critical examination of whether the assumptions implicit within these theoretical paradigms are applicable toSIDScontexts. This study reviews the water management, governance, and island studies literatures to identify the ways in which the unique historical, geographical, and economic contexts ofSIDSlimit or enable the applicability of these paradigms. The analysis shows that each paradigm has a different underlying conceptualization of governance, and how institutions can regulate social–ecological relations for achieving water security. The conceptualizations of governance under the adaptive management paradigm seem to most closely reflect the complexity of governance inSIDS, and may therefore hold the most potential for addressing water insecurity. However, the analysis also highlights the need for further research to test the application of adaptive management in a way that can also cater for the unique socio‐political relations that affect the outcomes of governance inSIDS.WIREs Water2016, 3:181–193. doi: 10.1002/wat2.1129

This article is categorized under:

Human Water > Water Governance
Clustering techniques for neuroimaging applications
Authors: Derntl Alexandra , Plant Claudia
Published: December 2015

Clustering has been proven useful for knowledge discovery from massive data in many applications ranging from market segmentation to bioinformatics. In this study, we focus on clustering large amounts of medical image data of the human brain to identify structures of interest. Advanced Magnetic Resonance Imaging techniques enable unprecedented insights into the complex processes in the brain. However, especially for clinical studies, a huge amount of data has to be processed in order to find patterns characterizing the structure and function of the healthy brain and its alternations associated with diseases. We survey clustering methods specifically designed for neuroimaging applications such as segmentation of fiber tracks and lesions, as well as methods that can deal with multimodal imaging data. Furthermore, we will illustrate how clustering enables knowledge discovery from data by enhancing the performance of supervised techniques and discovering meaningful subgroups of subjects. The main purpose of this study is to give an introduction on how versatile clustering techniques can be applied in neuroimaging to tackle different applications where automated methods are desired. WIREs Data Mining Knowl Discov 2016, 6:22–36. doi: 10.1002/widm.1174

This article is categorized under:

Algorithmic Development > Biological Data Mining

Application Areas > Health Care

Technologies > Structure Discovery and Clustering
Grid-based Methods in Relativistic Hydrodynamics and Magnetohydrodynamics
Authors: Martí José María , Müller Ewald
Published: December 2015

An overview of grid-based numerical methods used in relativistic hydrodynamics (RHD) and magnetohydrodynamics (RMHD) is presented. Special emphasis is put on a comprehensive review of the application of high-resolution shock-capturing methods. Results of a set of demanding test bench simulations obtained with different numerical methods are compared in an attempt to assess the present capabilities and limits of the various numerical strategies. Applications to three astrophysical phenomena are briefly discussed to motivate the need for and to demonstrate the success of RHD and RMHD simulations in their understanding. The review further provides FORTRAN programs to compute the exact solution of the Riemann problem in RMHD, and to simulate 1D RMHD flows in Cartesian coordinates.
Novel Very Long‐Chain α‐Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB
Authors: Carballeira Néstor M. , Montano Nashbly , Amador Luis A. , Rodríguez Abimael D. , Golovko Mikhail Y. , Golovko Svetlana A. , Reguera Rosa M. , Álvarez‐Velilla Raquel , Balaña‐Fouce Rafael
Published: December 2015

The novel fatty acids (2R,5Z,9Z)‐2‐methoxy‐25‐methyl‐5,9‐hexacosadienoic acid (1a) and (2R,5Z,9Z)‐2‐methoxy‐24‐methyl‐5,9‐hexacosadienoic acid (1b) were isolated in 80 % purity from the Caribbean sponge Asteropus niger by chloroform/methanol extraction followed by solvent partitioning and silica gel column chromatography. The compounds were characterized by utilizing a combination of gas chromatography‐mass spectrometry, nuclear magnetic resonance, and circular dichroism. Acids 1a and 1b were not detected in the phospholipids (PtdCho and PtdIns) of the sponge, but rather as free FA and possibly in glycosylceramides. The mixtures of 1a and 1b displayed cytotoxicity towards THP‐1 and HepG2 cells with EC50's between 41 and 35 μg/mL. Apoptosis was not the preferred mode of cell death induced by 1a–1b in the THP‐1 cells. This implies other types of cytotoxicity mechanisms, such as membrane disruption and/or the inhibition (EC50 = 1.8 μg/mL) of the human topoisomerase IB enzyme (hTopIB), with a mechanism of inhibition different from the one displayed by camptothecin (CPT). In a separate experiment, the mixture of 1a and 1b also displayed cytotoxicity towards ex vivo mouse splenocytes infected with Leishmania infantum amastigotes (IC50 = 0.17 mg/mL) and free living promastigotes (IC50 = 0.34 mg/mL). It was also found that the FA were inhibitory of the Leishmania topoisomerase IB (LTopIB) with an EC50 = 5.1 μg/mL. Taken together, 1a and 1b represent a new class of FA with potential as TopIB inhibitors that preferentially inhibit hTopIB over LTopIB.
Chemical Properties and Fatty Acid Composition of Thunbergia fragrans Roxb. Seed Oil
Authors: Payamalle Shivanand , Shinde Smita , Joseph Kadanthottu Sebastian , Mutakekar Sonal , Murgude Manisha , Tawadare Rakesh , Murthy Hosakatte Niranjana
Published: December 2015

The physicochemical and fatty acid compositions of seed oil extracted from Thunbergia fragrans were determined. The oil content, free fatty acids, peroxide value, saponification value and iodine value were 21.70 %, 2.25 % (as oleic acid), 9.6 (mequiv. O2/kg), 191.71 (mg KOH/g) and 127.84 (g/100 g oil) respectively. The fatty acid profiles of the methyl esters showed the presence of 90.16 % unsaturated fatty acids and 9.84 % saturated fatty acids. Palmitoleic acid, which is usually found in marine foods and is unique in seed oils of botanical origin, was the major component (79.24 %). The oil can also be used in industries for the preparation of liquid soaps, shampoos and alkyd resin.
Effect of nanoparticles on the performance of magnetorheological fluid damper during hard turning process
Authors: Paul P. Sam , Iasanth J. Agnelo , Vasanth X. Ajay , Varadarajan A. S.
Published: December 2015

Magnetorheological (MR) fluid damper which allows the damping characteristics of the damper to be continuously controlled by varying the magnetic field is extensively used in metal cutting to suppress tool vibration. Even though magnetorhelogical fluids have been successful in reducing tool vibration, durability of magnetorhelogical fluids remains a major challenge in engineering sector. Temperature effect on the performance of magnetorhelogical fluids over a prolonged period of time is a major concern. In this paper, an attempt was made to reduce temperature and to improve viscosity of magnetorhelogical fluids by infusing nanoparticles along with MR fluids. Aluminium oxide and titanium oxide nanoparticles of 0.1% and 0.2% concentration by weight were considered and experimental tests were conducted to study the influence of nanoparticles on the performance of magnetorheological fluid. From the experimental results it was observed that the presence of nanoparticles in MR fluid reduces temperature and increases the viscosity of MR fluid thereby increasing the cutting performance during turning of hardened AISI 4340 steel.
Load carrying capacity of a heterogeneous surface bearing
Authors: Thomas Evan , Pascovici Mircea D. , Glovnea Romeo P.
Published: December 2015

It has been shown before that liquids can slip at a solid boundary, which prompted the idea that parallel-surfaces bearings can be achieved just by alternating slip and non-slip regions in the direction of fluid flow. The amount of slip at the wall depends on the surface tension at the liquid–solid interface, which in turn depends on the chemical state of the surface and its roughness. In the present study a heterogeneous surface was obtained by coating half of a circular glass disc with a coating repellant to glycerol. A rotating glass disc was placed at a known/calibrated distance and the gap was filled with glycerol. With the mobile surface moving from the direction of slip to non-slip region it can be theoretically shown that a pressure build up can be achieved. The pressure gradient in the two regions is constant, similar to that in a Rayleigh step bearing, with the maximum pressure at the separation line. The heterogeneous disc was placed on a holder supported by a load cell thus the force generated by this pressure increase can be measured accurately. Tests were carried out at different sliding speeds and gaps and the load carried was measured and subsequently compared with theoretical calculations. This allowed the slip coefficient to be evaluated.
Generic regularity of conservative solutions to a nonlinear wave equation
Authors: Bressan Alberto , Chen Geng
Published: December 2015

The paper is concerned with conservative solutions to the nonlinear wave equation

u_{tt}−c(u)(c(u)u_{x})_{x} = 0

. For an open dense set of

\mathcal{C}^{3}

initial data, we prove that the solution is piecewise smooth in the

t–x

plane, while the gradient

u_{x}

can blow up along finitely many characteristic curves. The analysis is based on a variable transformation introduced in [7], which reduces the equation to a semilinear system with smooth coefficients, followed by an application of Thom's transversality theorem.
Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging
Authors: Gupta Veer Bala , Doecke James D. , Hone Eugene , Pedrini Steve , Laws Simon M. , Thambisetty Madhav , Bush Ashley I. , Rowe Christopher C. , Villemagne Victor L. , Ames David , Masters Colin L. , Macaulay Stuart Lance , Rembach Alan , Rainey‐Smith Stephanie R. , Martins Ralph N. ,   AIBL Research Group
Published: December 2015

Introduction

For early detection of Alzheimer's disease (AD), the field needs biomarkers that can be used to detect disease status with high sensitivity and specificity. Apolipoprotein J (ApoJ, also known as clusterin) has long been associated with AD pathogenesis through various pathways. The aim of this study was to investigate the potential of plasma apoJ as a blood biomarker for AD.

Methods

Using the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, the present study assayed plasma apoJ levels over baseline and 18 months in 833 individuals. Plasma ApoJ levels were analyzed with respect to clinical classification, age, gender, apolipoprotein E (APOE) ε4 allele status, mini‐mental state examination score, plasma amyloid beta (Aβ), neocortical Aβ burden (as measured by Pittsburgh compound B‐positron emission tomography), and total adjusted hippocampus volume.

Results

ApoJ was significantly higher in both mild cognitive impairment (MCI) and AD groups as compared with healthy controls (HC; P < .0001). ApoJ significantly correlated with both “standardized uptake value ratio” (SUVR) and hippocampus volume and weakly correlated with the plasma Aβ1–42/Aβ1–40 ratio. Plasma apoJ predicted both MCI and AD from HC with greater than 80% accuracy for AD and greater than 75% accuracy for MCI at both baseline and 18‐month time points.

Discussion

Mean apoJ levels were significantly higher in both MCI and AD groups. ApoJ was able to differentiate between HC with high SUVR and HC with low SUVR via APOE ε4 allele status, indicating that it may be included in a biomarker panel to identify AD before the onset of clinical symptoms.
Monitoring vascular normalization induced by antiangiogenic treatment with 18F‐fluoromisonidazole‐PET
Authors: Hernández-Agudo Elena , Mondejar Tamara , Soto-Montenegro Maria Luisa , Megías Diego , Mouron Silvana , Sanchez Jesus , Hidalgo Manuel , Lopez-Casas Pedro Pablo , Mulero Francisca , Desco Manuel , Quintela-Fandino Miguel
Published: December 2015

Background: Rationalization of antiangiogenics requires biomarkers. Vascular re‐normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with 18F‐misonidazole ([18F]‐FMISO, a probe that detects hypoxia) PET, in response to window‐of‐opportunity (WoO) treatment with the antiangiogenic dovitinib.

Methods: Two patient‐derived pancreas xenografts (PDXs; Panc215 and Panc286) and the spontaneous breast cancer model MMTV‐PyMT were used. Animals were treated during 1 week of WoO treatment with vehicle or dovitinib, preceded and followed by [18F]‐FMISO‐PET, [18F]‐FDG‐PET, and histologic assessment (dextran extravasation, hypoxia and microvessel staining, and necrosis, cleaved caspase‐3 and Ki67 measurements). After WoO treatment, gemcitabine (pancreas)/adriamycin (breast) or vehicle was added and animals were treated until the humane endpoint. Tumor growth inhibition (TGI) and survival were the parameters studied.

Results: [18F]‐FMISO SUV did not change after dovitinib‐WoO treatment compared to vehicle‐WoO (0.54 vs. 0.6) treatment in Panc215, but it decreased significantly in Panc286 (0.58 vs. 1.18; P < 0.05). In parallel, 10‐KDa perivascular dextran extravasation was not reduced with dovitinib or vehicle‐WoO treatment in Panc215, but it was reduced in Panc286. Whereas the addition of dovitinib to gemcitabine was indifferent in Panc215, it increased TGI in Panc286 (TGI switched from −59% to +49%). [18F]‐FMISO SUV changes were accompanied by an almost 100% increase in interstitial gemcitabine delivery (665–1260 ng/mL). The results were validated in the PyMT model.

Conclusions: [18F]‐FMISO accurately monitored vascular re‐normalization and improved interstitial chemotherapy delivery.
Baltimore’s Unrest: Perspectives From Public Health and Emergency Physician Leaders
Authors: Khaldun Joneigh S. , Warren Katherine E. , Wen Leana S.
Published: December 2015

The tragic April 19, 2015, death of an African American man injured while in police custody spurred several days of protest and civil unrest in Baltimore City. This article outlines the opportunity and role for a local health department during civil unrest, from the perspective of 2 emergency physicians who also led the Baltimore City Health Department through these recent events. Between April 27 and May 8, 2015, the Health Department was a lead agency in the unrest response and recovery activities. Similar to an emergency medical situation, a “public health code” is proposed as a model for centralizing, reacting to, and debriefing after situations of civil unrest. (Disaster Med Public Health Preparedness. 2016;10:293–295)
Dissipative distinctions
Authors: Castro Ian P.
Published: December 2015

There have been numerous studies concerning the possibility of self-similar scaling laws in fully developed turbulent shear flows, driven over the past half-century or so by the early seminal work of Townsend (1956, The Structure of Turbulent Shear Flow. Cambridge University Press). His and nearly all subsequent analyses depend crucially on a hypothesis about the nature of the dissipation, ${\it\epsilon}$, of turbulence kinetic energy, $k$. It has usually been assumed (sometimes implicitly) that this is governed by the famous Kolmogorov relation ${\it\epsilon}=C_{{\it\epsilon}}k^{3/2}/L$, where $L$ is a length scale of the energy-containing eddies and $C_{{\it\epsilon}}$ is a constant. The paper by Dairay et al. (J. Fluid Mech. vol. 781, 2015, pp. 166–195) demonstrates, however, that, in the specific context of an axisymmetric wake, there can be regions where ${\it\epsilon}$ has a different behaviour, characterised by a $C_{{\it\epsilon}}$ that is not constant but depends on a varying local Reynolds number (despite the existence of a $-5/3$ region in the spectra). This leads to fundamentally different scaling laws for the wake.
The role of mixed-layer instabilities in submesoscale turbulence
Authors: Callies Jörn , Flierl Glenn , Ferrari Raffaele , Fox-Kemper Baylor
Published: December 2015

Upper-ocean turbulence at scales smaller than the mesoscale is believed to exchange surface and thermocline waters, which plays an important role in both physical and biogeochemical budgets. But what energizes this submesoscale turbulence remains a topic of debate. Two mechanisms have been proposed: mesoscale-driven surface frontogenesis and baroclinic mixed-layer instabilities. The goal here is to understand the differences between the dynamics of these two mechanisms, using a simple quasi-geostrophic model. The essence of mesoscale-driven surface frontogenesis is captured by the well-known surface quasi-geostrophic model, which describes the sharpening of surface buoyancy gradients and the subsequent breakup in secondary roll-up instabilities. We formulate a similarly archetypical Eady-like model of submesoscale turbulence induced by mixed-layer instabilities. The model captures the scale and structure of this baroclinic instability in the mixed layer. A wide range of scales are energized through a turbulent inverse cascade of kinetic energy that is fuelled by the submesoscale mixed-layer instability. Major differences to mesoscale-driven surface frontogenesis are that mixed-layer instabilities energize the entire depth of the mixed layer and produce larger vertical velocities. The distribution of energy across scales and in the vertical produced by our simple model of mixed-layer instabilities compares favourably to observations of energetic wintertime submesoscale flows, suggesting that it captures the leading-order balanced dynamics of these flows. The dynamics described here in an oceanographic context have potential applications to other geophysical fluids with layers of different stratifications.
A spectral model for homogeneous shear-driven anisotropic turbulence in terms of spherically averaged descriptors
Authors: Mons Vincent , Cambon Claude , Sagaut Pierre
Published: December 2015

A nonlinear spectral model in terms of spherically averaged descriptors is derived for the prediction of homogeneous turbulence dynamics in the presence of arbitrary mean-velocity gradients. The governing equations for the tensor $\hat{\unicode[STIX]{x1D619}}_{ij}(\boldsymbol{k},t)$, the Fourier transform of the two-point second-order correlation tensor, are first closed by an anisotropic eddy-damped quasinormal Markovian procedure. This closure is restricted to turbulent flows where linear effects induced by mean-flow gradients have no essential qualitative effects on the dynamics of triple correlations compared with the induced production effects in the equations for second-order correlations. Truncation at the first relevant order of spectral angular dependence allows us to derive from these equations in vector $\boldsymbol{k}$ our final model equations in terms of the wavenumber modulus $k$ only. Analytical spherical integration results in a significant decrease in computational cost. Besides, the model remains consistent with the decomposition in terms of directional anisotropy and polarization anisotropy, with a spherically averaged anisotropic spectral tensor for each contribution. Restriction of anisotropy to spherically averaged descriptors, however, entails a loss of information, and realizability conditions are considered to quantify the upper boundary of anisotropy that can be investigated with the proposed model. Several flow configurations are considered to assess the validity of the present model. Satisfactory agreement with experiments on grid-generated turbulence subjected to successive plane strains is observed, which confirms the capability of the model to account for production of anisotropy by mean-flow gradients. The nonlinear transfer terms of the model are further tested by considering the return to isotropy (RTI) of different turbulent flows. Different RTI rates for directional anisotropy and polarization anisotropy allow us to correctly predict the apparent delayed RTI shown after axisymmetric expansion. The last test case deals with homogeneous turbulence subjected to a constant pure plane shear. The interplay between linear and nonlinear effects is reproduced, yielding the eventual exponential growth of the turbulent kinetic energy.
SEMILATTICES AND THE RAMSEY PROPERTY
Authors: SOKIĆ MIODRAG
Published: December 2015

We consider${\cal S}$, the class of finite semilattices;${\cal T}$, the class of finite treeable semilattices; and${{\cal T}_m}$, the subclass of${\cal T}$which contains trees with branching bounded bym. We prove that${\cal E}{\cal S}$, the class of finite lattices with linear extensions, is a Ramsey class. We calculate Ramsey degrees for structures in${\cal S}$,${\cal T}$, and${{\cal T}_m}$. In addition to this we give a topological interpretation of our results and we apply our result to canonization of linear orderings on finite semilattices. In particular, we give an example of a Fraïssé class${\cal K}$which is not a Hrushovski class, and for which the automorphism group of the Fraïssé limit of${\cal K}$is not extremely amenable (with the infinite universal minimal flow) but is uniquely ergodic.
A PSEUDOEXPONENTIAL-LIKE STRUCTURE ON THE ALGEBRAIC NUMBERS
Authors: MANTOVA VINCENZO
Published: December 2015

Pseudoexponential fields are exponential fields similar to complex exponentiation which satisfy the Schanuel Property, i.e., the abstract statement of Schanuel’s Conjecture, and an adapted form of existential closure.

Here we show that if we remove the Schanuel Property and just care about existential closure, it is possible to create several existentially closed exponential functions on the algebraic numbers that still have similarities with complex exponentiation. The main difficulties are related to the arithmetic of algebraic numbers, and they can be overcome with known results about specialisations of multiplicatively independent functions on algebraic varieties.
MATHIAS FORCING AND COMBINATORIAL COVERING PROPERTIES OF FILTERS
Authors: CHODOUNSKÝ DAVID , REPOVŠ DUŠAN , ZDOMSKYY LYUBOMYR
Published: December 2015

We give topological characterizations of filters${\cal F}$onωsuch that the Mathias forcing${M_{\cal F}}$adds no dominating reals or preserves ground model unbounded families. This allows us to answer some questions of Brendle, Guzmán, Hrušák, Martínez, Minami, and Tsaban.
AUTOMORPHISM GROUPS OF COUNTABLE ARITHMETICALLY SATURATED MODELS OF PEANO ARITHMETIC
Authors: SCHMERL JAMES H.
Published: December 2015

If${\cal M},{\cal N}$are countable, arithmetically saturated models of Peano Arithmetic and${\rm{Aut}}\left( {\cal M} \right) \cong {\rm{Aut}}\left( {\cal N} \right)$, then the Turing-jumps of${\rm{Th}}\left( {\cal M} \right)$and${\rm{Th}}\left( {\cal N} \right)$are recursively equivalent.
ON THE SPLITTING NUMBER AT REGULAR CARDINALS
Authors: BEN-NERIA OMER , GITIK MOTI
Published: December 2015

Letκ, λ be regular uncountable cardinals such that λ >κ+is not a successor of a singular cardinal of low cofinality. We construct a generic extension withs(κ) = λ starting from a ground model in whicho(κ) = λ and prove that assuming ¬0¶,s(κ) = λ implies thato(κ) ≥ λ in the core model.
SEPARABLE MODELS OF RANDOMIZATIONS
Authors: ANDREWS URI , KEISLER H. JEROME
Published: December 2015

Every complete first order theory has a corresponding complete theory in continuous logic, called the randomization theory. It has two sorts, a sort for random elements of models of the first order theory, and a sort for events. In this paper we establish connections between properties of countable models of a first order theory and corresponding properties of separable models of the randomization theory. We show that the randomization theory has a prime model if and only if the first order theory has a prime model. And the randomization theory has the same number of separable homogeneous models as the first order theory has countable homogeneous models. We also show that when T has at most countably many countable models, each separable model of TR is uniquely characterized by a probability density function on the set of isomorphism types of countable models of T. This yields an analogue for randomizations of the results of Baldwin and Lachlan on countable models of ω1-categorical first order theories.
COMPARING THE STRENGTH OF DIAGONALLY NONRECURSIVE FUNCTIONS IN THE ABSENCE OF INDUCTION
Authors: DORAIS FRANÇOIS G. , HIRST JEFFRY L. , SHAFER PAUL
Published: December 2015

We prove that the statement “there is aksuch that for everyfthere is ak-bounded diagonally nonrecursive function relative tof” does not imply weak König’s lemma over${\rm{RC}}{{\rm{A}}_0} + {\rm{B\Sigma }}_2^0$. This answers a question posed by Simpson. A recursion-theoretic consequence is that the classic fact that everyk-bounded diagonally nonrecursive function computes a 2-bounded diagonally nonrecursive function may fail in the absence of${\rm{I\Sigma }}_2^0$.
RANDOMNESS IN THE HIGHER SETTING
Authors: CHONG C. T. , YU LIANG
Published: December 2015

We study the strengths of various notions of higher randomness: (i) strong ${\rm{\Pi }}_1^1$randomness is separated from ${\rm{\Pi }}_1^1$randomness; (ii) the hyperdegrees of ${\rm{\Pi }}_1^1$random reals are closed downwards (except for the trivial degree); (iii) the reals z in $NC{R_{{\rm{\Pi }}_1^1}}$ are precisely those satisfying $z \in {L_{\omega _1^z}}$ and (iv) lowness for ${\rm{\Delta }}_1^1$randomness is strictly weaker than that for ${\rm{\Pi }}_1^1$randomness.
Research on Chinese Family Businesses: Perspectives
Authors: Li Xin Chun , Chen Ling , Chua Jess H. , Kirkman Bradley L. , Rynes-Weller Sara , Gomez-Mejia Luis
Published: December 2015

This introduction traces the disappearance of Chinese family businesses from 1949 to 1978, their revival since then, and their future challenges. It then summarizes the three papers included in this Special Issue and proposes an agenda for family business studies in China. The article first focuses on the nonmarket social and political network strategies that these family-centered business organizations have had to adopt in order to overcome the difficulties they faced in accessing opportunities and resources as a result of Chinese culture's traditional low esteem for merchants and the government's continuing preference for a state-dominated economy. Family firms have so far been able to grow disproportionately rapidly in China's economy because, by leveraging the shared interests and dedication of immediate and extended family members, they have been able to achieve lower cost and higher efficiency, respond quickly to market changes, and expand social and political networks. These nonmarket strategies, however, also have a dark side. Furthermore, as the liberalization of China's economy deepens, competition must rely critically on market strategies such as innovation, alliances, and internationalization. The proposed research agenda addresses these future challenges as well as some research questions unique to Chinese family businesses.
From on High: The Effect of Elite Polarization on Mass Attitudes and Behaviors, 1972–2012
Authors: Zingher Joshua N. , Flynn Michael E.
Published: December 2015

Though there is widespread scholarly consensus that American political elites have become increasingly ideologically polarized, there remains debate about how the mass electorate has responded to the increase in polarization at the elite level. This article shows that as party elites have become more polarized, individuals have become better able to identify the party that best matches their own ideological positions, thereby contributing to polarization at the mass level. Using forty years of ANES and DW-NOMINATE data to test this argument, it was found that the relationship between a voter’s position in policy space and their political behavior is indeed conditional upon polarization at the elite level. This finding demonstrates how changes in elite polarization translate to behavioral changes on the mass level.
Absent Maps, Marine Science, and the Reimagination of the South China Sea, 1922–1939
Authors: Sasges Gerard
Published: December 2015

Today, seven nations have maritime or island claims in the disputed South China Sea. This article historicizes the claims of one of the dispute's participants, the Socialist Republic of Vietnam. It argues that cartographic representations of its territory have their origin in the period of French rule, and locates a key moment in the formation of an Indochinese—and later Vietnamese—space encompassing the South China Sea in a series of four maps that represented research carried out by the colonial Institute of Oceanography. By recreating the biographies of these maps, the article reveals their origin in a contingent interplay of multiple factors, including global scientific networks, economic development, imperial defense, and personal research agendas. The article suggests that attention to the biographies of maps could be an effective means of deconstructing and denaturalizing many of the territorial claims that drive the dispute in the South China Sea today.
‘We Should not Content Ourselves with a Sham’: The US Foreign Service and the Central American Elections of the Early 1930s
Authors: VAN DEN BERK JORRIT
Published: December 2015

Scholars have paid considerable attention to the connection between Washington's withdrawal from intervention and the emergence of dictatorship in Central America during the 1930s. The current article seeks to enhance our understanding of those interconnected developments through the investigation of the US Foreign Service and its role in the early 1930s presidential campaigns in Guatemala, El Salvador, and Honduras. It shows that the dynamic interaction between actors in both Washington and Central America set in motion a process that would produce decades of authoritarian rule in the isthmus.
Resistance rather than tolerance explains survival of savannah honeybees (Apis mellifera scutellata) to infestation by the parasitic mite Varroa destructor
Authors: STRAUSS URSULA , DIETEMANN VINCENT , HUMAN HANNELIE , CREWE ROBIN M. , PIRK CHRISTIAN W. W.
Published: December 2015

Varroa destructor is considered the most damaging parasite affecting honeybees (Apis mellifera L.). However, some honeybee populations such as the savannah honeybee (Apis mellifera scutellata) can survive mite infestation without treatment. It is unclear if survival is due to resistance mechanisms decreasing parasite reproduction or to tolerance mechanisms decreasing the detrimental effects of mites on the host. This study investigates both aspects by quantifying the reproductive output of V. destructor and its physiological costs at the individual host level. Costs measured were not consistently lower when compared with susceptible honeybee populations, indicating a lack of tolerance. In contrast, reproduction of V. destructor mites was distinctly lower than in susceptible populations. There was higher proportion of infertile individuals and the reproductive success of fertile mites was lower than measured to date, even in surviving populations. Our results suggest that survival of savannah honeybees is based on resistance rather than tolerance to this parasite. We identified traits that may be useful for breeding programmes aimed at increasing the survival of susceptible populations. African honeybees may have benefited from a lack of human interference, allowing natural selection to shape a population of honeybees that is more resistant to Varroa mite infestation.
Family care-giving and living arrangements of functionally impaired elders in rural China
Authors: GRUIJTERS ROB J.
Published: December 2015

China has seen a rapid decline of the traditional multi-generational household and an increase in rural-to-urban migration, raising concerns about a possible breakdown of the informal support system. Against this background, the paper looks at family care-giving (or the absence thereof) to parents in three different living arrangements: with any child or child-in-law (co-resident); independent with at least one child living in the same community (networked); and without any children in either the household or the community (isolated). It also compares the care-giving arrangements of single elders to those living with a spouse. The sample, which is derived from the comprehensive China Health and Retirement Longitudinal Study (CHARLS), contains data on 887 functionally impaired individuals aged 60 and above. The findings suggest that married parents are mostly cared for by their spouse, even if they co-reside with adult children. Proximity to children is particularly important for single elders, who are more likely to lack a care-giver when living independently. There appears to be a hierarchy in family care responsibilities, where children step in as care-givers only when the spouse is no longer able to fulfil this role. While these findings imply a significant deviation from traditional practices and norms of ‘filial piety’, they can be interpreted as a rational adaptation to the changed economic circumstances in rural China.
Model risk – daring to open up the black box
Authors: Aggarwal A. , Beck M. B. , Cann M. , Ford T. , Georgescu D. , Morjaria N. , Smith A. , Taylor Y. , Tsanakas A. , Witts L. , Ye I.
Published: December 2015

With the increasing use of complex quantitative models in applications throughout the financial world, model risk has become a major concern. Such risk is generated by the potential inaccuracy and inappropriate use of models in business applications, which can lead to substantial financial losses and reputational damage. In this paper, we deal with the management and measurement of model risk. First, a model risk framework is developed, adapting concepts such as risk appetite, monitoring, and mitigation to the particular case of model risk. The usefulness of such a framework for preventing losses associated with model risk is demonstrated through case studies. Second, we investigate the ways in which different ways of using and perceiving models within an organisation both lead to different model risks. We identify four distinct model cultures and argue that in conditions of deep model uncertainty, each of those cultures makes a valuable contribution to model risk governance. Thus, the space of legitimate challenges to models is expanded, such that, in addition to a technical critique, operational and commercial concerns are also addressed. Third, we discuss through the examples of proxy modelling, longevity risk, and investment advice, common methods and challenges for quantifying model risk. Difficulties arise in mapping model errors to actual financial impact. In the case of irreducible model uncertainty, it is necessary to employ a variety of measurement approaches, based on statistical inference, fitting multiple models, and stress and scenario analysis.
The history of the Conference of Research Workers in Animal Diseases (CRWAD) 1920–2014
Authors: Ellis Robert P. , Ellis L. Susanne Squires , Kohler Erwin M.
Published: December 2015

The following history has been compiled and written by the authors. The historical facts are available from the Conference of Research Workers in Animal Diseases (CRWAD) archives, dating back to letters and summaries written by the founders, and by a few of the Secretary-Treasurers from the early decades through 2014. The Organization and Purpose: The CRWAD is a non-profit organization and has been since its origin. The sole purpose of CRWAD is to discuss and disseminate the most current research advances in animal diseases. Graduate students and industry and academic professionals present and discuss the most recent advances on subjects of interest to the CRWAD and of importance to the global livestock and companion animal industries. The oral and poster abstracts of new and unpublished data presented at the meeting sessions are published each year in the CRWAD Proceedings (formerly the CRWAD Abstracts). CRWAD publishes, copyrights, and distributes the Proceedings. The presentations are arranged into the following 10 sections, according to the primary topic of the presentation: Bacterial Pathogenesis, Biosafety and Biosecurity, Companion Animal Epidemiology, Ecology and Management of Foodborne Agents, Epidemiology and Animal Health Economics, Immunology, Pathobiology of Enteric and Foodborne Pathogens, Respiratory Diseases, Vector-Borne and Parasitic Diseases, and Viral Pathogenesis. Prospective members should be actively engaged in animal disease research or research administration. Meeting information and membership applications may be obtained by contacting the Executive Director or by visiting the CRWAD website. Annual abstracts are currently available on-line at the On-line Meeting Planner and Itinerary Builder, with access through the CRWAD website.
Differences in Religiousness in Opposite-Sex and Same-Sex Twins in a Secular Society
Authors: Ahrenfeldt Linda J. , Lindahl-Jacobsen Rune , Möller Sören , Christensen Kaare , Hvidtjørn Dorte , Hvidt Niels Christian
Published: December 2015

Sex differences in religion are well known, with females generally being more religious than males, and shared environmental factors have been suggested to have a large influence on religiousness. Twins from opposite-sex (OS) and same-sex (SS) pairs may differ because of a dissimilar psycho-social rearing environment and/or because of different exposures to hormones in utero. We hypothesized that OS females may display more masculine patterns of religiousness and, vice versa, that OS males may display more feminine patterns. We used a web-based survey conducted in Denmark, which is a secular society. The survey included 2,997 twins aged 20–40 years, identified through the population-based Danish Twin Registry. We applied la Cour and Hvidt's adaptation of Fishman's three conceptual dimensions of meaning: Cognition, Practice, and Importance, and we used Pargament's measure of religious coping (RCOPE) for the assessment of positive and negative religious coping patterns. Differences between OS and SS twins were investigated using logistic regression for each sex. The analyses were adjusted for dependence within twin pairs. No significant differences in religiousness and religious coping were found for OS and SS twins except that more OS than SS females were members of the Danish National Evangelical Lutheran Church and fewer OS than SS females were Catholic, Muslim, or belonged to other religious denominations. Moreover, OS males at age 12 had higher rates of church attendance than did SS males. This study did not provide evidence for masculinization of female twins with male co-twins with regard to religiousness. Nor did it show any significant differences between OS and SS males except from higher rates of church attendance in childhood among males with female co-twins.
The Unitary Ability of IQ and Indexes in WAIS-IV
Authors: Orsini Arturo , Pezzuti Lina , Hulbert Sabina
Published: December 2015

Abstract. Lichtenberger and Kaufman (2009, p. 167) defined unitary ability as “an ability […] that is represented by a cohesive set of scaled scores, each reflecting slightly different or unique aspects of the ability.” Flanagan and Kaufman (2009) and Lichtenberger and Kaufman (2012) , to define unitarity of IQ, use a difference of 23 IQ points between the highest score (Max) and the lowest score (Min) obtained by a subject in the four Indexes of WAIS-IV. A similar method has been used to assess the unitary ability for the four Indexes, with the threshold of 5. Such difference score (of 23 for IQ and 5 for Indexes) are considered high and infrequent and, the authors therefore conclude that the corresponding Full-Scale IQ score or Index score is uninterpretable. In this paper we argue that these thresholds are inappropriate because they are based on the wrong standard deviation. The main aim of this study was to establish variability thresholds for IQ and the WAIS-IV Indexes for the American standardization sample and to compare these thresholds with those for the Italian standardization sample. We also consider an alternative approach to determining whether an IQ score represents a unitary ability based on the maximum difference score for the 10 core subtests that contribute to Full-Scale IQ.
Ultra-low-frequency wave-driven diffusion of radiation belt relativistic electrons
Authors: Su Zhenpeng , Zhu Hui , Xiao Fuliang , Zong Q.-G. , Zhou X.-Z. , Zheng Huinan , Wang Yuming , Wang Shui , Hao Y.-X. , Gao Zhonglei , He Zhaoguo , Baker D. N. , Spence H. E. , Reeves G. D. , Blake J. B. , Wygant J. R.
Published: December 2015

Van Allen radiation belts are typically two zones of energetic particles encircling the Earth separated by the slot region. How the outer radiation belt electrons are accelerated to relativistic energies remains an unanswered question. Recent studies have presented compelling evidence for the local acceleration by very-low-frequency (VLF) chorus waves. However, there has been a competing theory to the local acceleration, radial diffusion by ultra-low-frequency (ULF) waves, whose importance has not yet been determined definitively. Here we report a unique radiation belt event with intense ULF waves but no detectable VLF chorus waves. Our results demonstrate that the ULF waves moved the inner edge of the outer radiation belt earthward 0.3 Earth radii and enhanced the relativistic electron fluxes by up to one order of magnitude near the slot region within about 10 h, providing strong evidence for the radial diffusion of radiation belt relativistic electrons.
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese
Authors: Tang Clara S. , Zhang He , Cheung Chloe Y. Y. , Xu Ming , Ho Jenny C. Y. , Zhou Wei , Cherny Stacey S. , Zhang Yan , Holmen Oddgeir , Au Ka-Wing , Yu Haiyi , Xu Lin , Jia Jia , Porsch Robert M. , Sun Lijie , Xu Weixian , Zheng Huiping , Wong Lai-Yung , Mu Yiming , Dou Jingtao , Fong Carol H. Y. , Wang Shuyu , Hong Xueyu , Dong Liguang , Liao Yanhua , Wang Jiansong , Lam Levina S. M. , Su Xi , Yan Hua , Yang Min-Lee , Chen Jin , Siu Chung-Wah , Xie Gaoqiang , Woo Yu-Cho , Wu Yangfeng , Tan Kathryn C. B. , Hveem Kristian , Cheung Bernard M. Y. , Zöllner Sebastian , Xu Aimin , Eugene Chen Y , Jiang Chao Qiang , Zhang Youyi , Lam Tai-Hing , Ganesh Santhi K. , Huo Yong , Sham Pak C. , Lam Karen S. L. , Willer Cristen J. , Tse Hung-Fat , Gao Wei
Published: December 2015

Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P<2.69 × 10−7), including three Asian-specific coding variants in known genes (CETP p.Asp459Gly, PCSK9 p.Arg93Cys and LDLR p.Arg257Trp). Furthermore, missense variants at two novel loci—PNPLA3 p.Ile148Met and PKD1L3 p.Thr429Ser—also influence levels of triglycerides and low-density lipoprotein cholesterol, respectively. Another novel gene, TEAD2, is found to be associated with high-density lipoprotein cholesterol through gene-based association analysis. Most of these newly identified coding variants show suggestive association (P<0.05) with CAD. These findings demonstrate that exome-wide genotyping on samples of non-European ancestry can identify additional population-specific possible causal variants, shedding light on novel lipid biology and CAD.
NSD1 mutations generate a genome-wide DNA methylation signature
Authors: Choufani S. , Cytrynbaum C. , Chung B. H. Y. , Turinsky A. L. , Grafodatskaya D. , Chen Y. A. , Cohen A. S. A. , Dupuis L. , Butcher D. T. , Siu M. T. , Luk H. M. , Lo I. F. M. , Lam S. T. S. , Caluseriu O. , Stavropoulos D. J. , Reardon W. , Mendoza-Londono R. , Brudno M. , Gibson W. T. , Chitayat D. , Weksberg R.
Published: December 2015

Sotos syndrome (SS) represents an important human model system for the study of epigenetic regulation; it is an overgrowth/intellectual disability syndrome caused by mutations in a histone methyltransferase, NSD1. As layered epigenetic modifications are often interdependent, we propose that pathogenic NSD1 mutations have a genome-wide impact on the most stable epigenetic mark, DNA methylation (DNAm). By interrogating DNAm in SS patients, we identify a genome-wide, highly significant NSD1+/−-specific signature that differentiates pathogenic NSD1 mutations from controls, benign NSD1 variants and the clinically overlapping Weaver syndrome. Validation studies of independent cohorts of SS and controls assigned 100% of these samples correctly. This highly specific and sensitive NSD1+/− signature encompasses genes that function in cellular morphogenesis and neuronal differentiation, reflecting cardinal features of the SS phenotype. The identification of SS-specific genome-wide DNAm alterations will facilitate both the elucidation of the molecular pathophysiology of SS and the development of improved diagnostic testing.