bluuebunny/crossref_metadata_2025 huggingface dataset:
Alpha2-antiplasmin deficiency affects depression and anxiety-like behavior and apoptosis induced by stress in mice
Authors: Kanno Yosuke , Tsuchida Kaho , Maruyama Chihiro , Hori Kyoko , Teramura Hanako , Asahi Shiho , Matsuo Osamu , Ozaki Kei-ichi
Published: December 2021

Objectives

Depression is a psychiatric disorder that affects about 10% of the world’s population and is accompanied by anxiety. Depression and anxiety are often caused by various stresses. However, the etiology of depression and anxiety remains unknown. It has been reported that alpha2-antiplasmin (α2AP) not only inhibits plasmin but also has various functions such as cytokine production and cell growth. This study aimed to determine the roles of α2AP on the stress-induced depression and anxiety.

Methods

We investigated the mild repeated restraint stress-induced depressive and anxiety-like behavior in the α2AP+/+ and α2AP−/− mice using the social interaction test (SIT), sucrose preference test (SPT), and elevated plus maze (EPM).

Results

The stresses such as the mild repeated restraint stress suppressed α2AP expression in the hippocampus of mice, and the treatment of fluoxetine (selective serotonin reuptake inhibitor [SSRI]) recovered the stress-caused α2AP suppression. We also showed that α2AP deficiency promoted the mild restraint stress-stimulated depression-like behavior such as social withdrawal and apathy and apoptosis in mice. In contrast, α2AP deficiency attenuated the mild restraint stress induced the anxiety-like behavior in mice.

Conclusions

α2AP affects the pathogenesis of depression and anxiety induced by stress.
Effects of Yogic practices on cardiovascular system and salivary alpha amylase on Indian healthy jail inmates
Authors: Jain Khushbu , Pal Rameswar , Badoni Sachendra , Kaushik Jitender , Kumari Gond Pooja , Basavaraddi Ishwar V.
Published: December 2021

Objectives

Imprisoned people usually have a poor health status and an increase risk to suffer chronic debilitating conditions, co-infection due to their limitations in physical activity and mental disturbances. This study was carried to find out the health impacts of Yogic practice of Indian healthy jail inmates.

Methods

It was interventional single group pre-post design study. A total no of 30, Jail inmates including 08 female were participated in this study and practiced Yoga for six months. Body Mass Index, Heart Rate, Blood Pressure, Salivary alpha amylase activity (SAA) a stress marker were assessed before, after three months and after completion of six months of Yogic practice.

Results

Improvement was noted in all parameters, but significant improvement was noted in systolic blood pressure, diastolic blood pressure, mean blood pressure, double product a index of load in the heart and SAA following Yogic practice in total participants. Significant improvement was also noted in systolic blood pressure, diastolic blood pressure, mean blood pressure, double product a index of load in the heart and SAA following Yogic practice in male group. No significant effect was noted in female group.

Conclusions

The present study revealed that regular Yogic practice resulted in reduction blood pressure, load in the heart and stress in mail jail inmates, when it is practiced regularly and carefully.
Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression
Authors: Ali Afgar , Mahla Sattarzadeh Bardsiri , Reza Vahidi , Alireza Farsinejad
Published: December 2021

Aberrant expression of genes involved in methylation, including DNA methyltransferase 3 Beta (DNMT3B), can cause hypermethylation of various tumor suppressor genes. In this regard, various molecular factors such as microRNAs can play a critical role in regulating these methyltransferase enzymes and eventually downstream genes such as growth arrest specific 7 (GAS7). Accordingly, in the present study we aimed to predict regulatory effect of miRNAs on DNMT3B and GAS7 genes expression in melanoma cell line. hsa-miR-203a-3p and hsa-miR-29a-3p were predicted and selected using bioinformatics software. The Real-time PCR technique was performed to investigate the regulatory effect of these molecules on the DNMT3B and GAS7 genes expression. Expression analysis of DNMT3B gene in A375 cell line showed that there was a significant increase compared to control (p value = 0.0015). Analysis of hsa-miR-203a-3p and hsa-miR-29a-3p indicated the insignificant decreased expression in melanoma cell line compared to control (p value < 0.05). Compared to control, the expression of GAS7 gene in melanoma cells showed a significant decrease (p value = 0.0323). Finally, our findings showed that the decreased expression of hsa-miR-203a-3p and hsa-miR-29a-3p can hypothesize that their aberrant expression caused DNMT3B dysfunction, possible methylation of the GAS7 gene, and ultimately decreased its expression. However, complementary studies are necessary to definite comment.
Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4
Authors: Jin Luming , Chen Chaoyang , Huang Lipeng , Sun Qingyu , Bu Liang
Published: December 2021

Long noncoding RNA (lncRNA), specifically the upregulation of lncRNA NR2F1 antisense RNA 1 (NR2F1-AS1), has been involved in the progression of non-small cell lung cancer (NSCLC), but the mechanisms that underlie this remain unclear. In this study, the expression of NR2F1-AS1, miR-363-3p, and SOX4 was assessed in NSCLC cells. A loss-of-function assay was used to measure the tumorigenicity of NSCLC cells. The glycolysis and glutamine metabolism of NSCLC cells was also measured via extracellular acidification rate, consumption of glucose and glutamine, and production of lactate and ATP. The relationships among NR2F1-AS1, miR-363-3p, and SOX4 were detected via dual-luciferase reporter assay. HK-2, GLS1, and SOX4 levels were also analyzed. We found that both NSCLC tissues and cells had higher levels of NR2F1-AS1. Silencing of NR2F1-AS1 inhibited the tumorigenicity of cells in vitro and reduced the glycolysis and glutamine metabolism of NSCLC cells. Regarding its mechanism, NR2F1-AS1 positively regulated the SOX4 level by sponging miR-363-3p. Furthermore, miR-363-3p inhibition or SOX4 overexpression reversed the repressing role of sh-NR2F1-AS1 in the tumorigenicity of NSCLC cells. In summary, NR2F1-AS1 promotes the tumorigenicity of NSCLC cells by regulating miR-363-3p/SOX4.
Clinical genetic testing and counselling in autism spectrum disorder
Authors: Freitag Christine M. , Haslinger Denise , Yousaf Afsheen , Waltes Regina
Published: December 2021

Autism spectrum disorders (ASDs) are phenotypically as well as genetically heterogeneous developmental disorders with a strong heritability. Clinical and basic science research has described many replicated genetic risk factors. Many findings can well be translated into clinical human genetic practice. The current article summarizes results of genetic studies in ASD, provides a diagnostic algorithm for the clinical human genetic work-up reflecting the German health care system options and gives information with regard to the obligatory genetic counselling after a clinical genetic assessment.
Genetic and epigenetic findings in anorexia nervosa
Authors: Hirtz Raphael , Hinney Anke
Published: December 2021

Polygenic factors are relevant for the genetic predispositions to the eating disorder anorexia nervosa (AN). The most recent genome-wide association study (GWAS) for AN comprised almost 17,000 patients with AN and controls. A total of eight genome-wide significant polygenic loci associated with AN have been identified. Each single polygenic locus makes only a small contribution to the development of AN. Analyses across different traits successfully identified regions/genes for AN that had not been detected by analyses of the single traits. Functional studies of the genes derived by GWAS studies aim to improve the understanding of the biological mechanisms involved in eating disorders. Epigenetic studies have not yet successfully contributed to the understanding of AN.
Update on the genetic architecture of schizophrenia
Authors: Degenhardt Franziska
Published: December 2021

A long-established hypothesis is that schizophrenia has a strong genetic component. In the early 1990s, the first genetic variant that substantially increases risk for psychosis was identified. Since this initial reporting of deletions in the chromosomal region 22q11.2, nearly two decades passed until substantial insights into schizophrenia’s genetic architecture were gained. Schizophrenia is a polygenic disorder and genetic risk is conferred by both common and rare alleles distributed across the genome. A small number of rare, deleterious copy number variants (CNVs) are associated with moderate to substantial increases in individual risk to schizophrenia. These deletions and duplications are also associated with a range of neurodevelopmental disorders. The diagnostic investigation of CNVs in patients with schizophrenia is likely to represent one of the first examples of genetic testing in clinical psychiatry. The prerequisites for this are currently being defined.
Basics and disturbances of genomic imprinting
Authors: Prawitt Dirk , Haaf Thomas
Published: December 2021

Genomic imprinting ensures the parent-specific expression of either the maternal or the paternal allele, by different epigenetic processes (DNA methylation and histone modifications) that confer parent-specific marks (imprints) in the paternal and maternal germline, respectively. Most protein-coding imprinted genes are involved in embryonic growth, development, and behavior. They are usually organized in genomic domains that are regulated by differentially methylated regions (DMRs). Genomic imprints are erased in the primordial germ cells and then reset in a gene-specific manner according to the sex of the germline. The imprinted genes regulate and interact with other genes, consistent with the existence of an imprinted gene network. Defects of genomic imprinting result in syndromal imprinting disorders. To date a dozen congenital imprinting disorders are known. Usually, a given imprinting disorder can be caused by different types of defects, including point mutations, deletions/duplications, uniparental disomy, and epimutations. Causative trans-acting factors in imprinting disorders, including ZFP57 and the subcortical maternal complex (SCMC), have the potential to affect multiple DMRs across the genome, resulting in a multi-locus imprinting disturbance. There is evidence that mutations in components of the SCMC can confer an increased risk for imprinting disorders.
Molecular testing for imprinting disorders
Authors: Beygo Jasmin , Kanber Deniz , Eggermann Thomas , Begemann Matthias
Published: December 2021

Imprinting disorders are a group of rare diseases with a broad phenotypic spectrum caused by a wide variety of genetic and epigenetic disturbances of imprinted genes or gene clusters. The molecular genetic causes and their respective frequencies vary between the different imprinting disorders so that each has its unique requirements for the diagnostic workflow, making it challenging. To add even more complexity to this field, new molecular genetic causes have been identified over time and new technologies have enhanced the detectability e. g. of mosaic disturbances.

The precise identification of the underlying molecular genetic cause is of utmost importance in regard to recurrence risk in the families, tumour risk, clinical management and conventional and in the future therapeutic managements.

Here we give an overview of the imprinting disorders, their specific requirements for the diagnostic workup and the most common techniques used and point out possible pitfalls.
Inherited disorders of intermediary metabolism – a group-based approach
Authors: Zschocke Johannes
Published: December 2021

In the recently developed International Classification of Inherited Metabolic Disorders (ICIMD), more than one third of the 1450 listed conditions involve gene products required for intermediary metabolism. 225 of these diseases represent deficiencies of enzymes or transport proteins in the breakdown of nutrients, many of which cause acute “metabolic” presentations with typical biochemical features that are amenable to specific treatments. A group-based approach to these conditions not only assists in understanding and remembering them but facilitates the best choice of diagnostic tests and acute treatment. This review describes the basic characteristics of the 25 disease groups in the four categories of nutrient breakdown in intermediary metabolism, outlines the often relatively straight-forward diagnostic approach, and summarizes important therapeutic principles. It should also assist in the retrospective identification of likely metabolic disorders in the family history for genetic counselling.
Prospects and challenges for the genetic counsellor profession in the German-speaking countries: report of a workshop
Authors: Schwaninger Gunda , Heidemann Simone , Hofmann Wera , Maurer Tamara , Mayerhanser Katharina , Ronez Joelle , Schüler Herdit , Steinmüller Katharina , Rudnik-Schöneborn Sabine , Zschocke Johannes
Published: December 2021

The genetic counsellor profession has not yet been established in the German-speaking countries. In 2019 the Medical University of Innsbruck inaugurated the first German-taught Master’s degree programme in Genetic and Genomic Counselling. In order to discuss prospects and challenges of the genetic counsellor profession in Germany, Austria and Switzerland (DACH region), the MSc programme team organized a two-day workshop with international speakers and medical geneticists from the DACH region. Day 1 was dedicated to the history, training and international profile of the genetic counsellor profession. Day 2 focused on four specific topics: (i) professional role, (ii) acceptance and job title, (iii) formal requirements and (iv) remuneration concepts for genetic counsellors in the DACH region. The workshop showed that the key factor for the successful implementation of the genetic counsellor profession is acceptance and trust within the medical genetics team. Genetic counsellors complement patient care in aspects that might be underserved considering the increasing demand of counselling in genomic medicine. Successful establishment of the genetic counsellor profession will entail the development of interprofessional teams under medical supervision and in the team of medical geneticists.
Telemedicine – chances and challenges for medical genetics in Germany
Authors: Tecklenburg Johanna
Published: December 2021

Telemedicine has been in practical use for many years, mostly within the context of model projects. The current Covid-19 pandemic has accelerated the process of implementing telemedicine in standard care. Numerous regulations, as well as complex reimbursement structures play a role in the application of telemedicine in medical genetics in Germany. Discipline- and technology-specific challenges complicate the integration of technical solutions into the medical genetic practice. In previous studies teleconsultations and virtual consultations in medical genetics have proven their value as indicated by high levels of satisfaction in the users and showing no inferiority to in-person consultation in terms of psychosocial outcome. The next years will bring an increasing demand for genetic counseling that can hardly be met by the limited number of specialists in Germany. In this context telemedicine can help to close these gaps in standard care while strengthening the field by ensuring comprehensive medical genetic care. The German medical genetics community is asked to actively shape the process of implementation by defining areas of genetic counseling that are suitable for telemedicine, by regulating access for physicians and by contributing to the renumeration structures.
Novel sequencing technologies and bioinformatic tools for deciphering the non-coding genome
Authors: Schwarz Jana Marie , Lüpken Richard , Seelow Dominik , Kehr Birte
Published: December 2021

High-throughput sequencing techniques have significantly increased the molecular diagnosis rate for patients with monogenic disorders. This is primarily due to a substantially increased identification rate of disease mutations in the coding sequence, primarily SNVs and indels. Further progress is hampered by difficulties in the detection of structural variants and the interpretation of variants outside the coding sequence. In this review, we provide an overview about how novel sequencing techniques and state-of-the-art algorithms can be used to discover small and structural variants across the whole genome and introduce bioinformatic tools for the prediction of effects variants may have in the non-coding part of the genome.
Public data sources for regulatory genomic features
Authors: Garda Samuele , Schwarz Jana Marie , Schuelke Markus , Leser Ulf , Seelow Dominik
Published: December 2021

High-throughput technologies have led to a continuously growing amount of information about regulatory features in the genome. A wealth of data generated by large international research consortia is available from online databases. Disease-driven studies provide details on specific DNA elements or epigenetic modifications regulating gene expression in specific cellular and developmental contexts, but these results are usually only published in scientific articles. All this information can be helpful in interpreting variants in the regulatory genome. This review describes a selection of high-profile data sources providing information on the non-coding genome, as well as pitfalls and techniques to search and capture information from the literature.
Crystal structure of (E)-amino(2-((5-methylfuran-2-yl)methylene)hydrazinyl) methaniminium nitrate monohydrate, C14H26N10O10
Authors: Jin Ze-Sen , Liu E. , Liu Xiao-jing , Jian Fang-fang , Liang Tongling
Published: December 2021

C14H26N10O10, monoclinic, P21 (no. 4), a = 12.3337(3) Å, b = 3.87010(10) Å, c = 24.2368(6) Å, β = 97.644(2)°, V = 1146.61(5) Å3, Z = 2, R

gt
(F) = 0.0400, wR
ref(F
2) = 0.1092, T = 170 K.
The crystal structure of catena-poly[(1-(4-carboxybenzyl)pyridin-1-ium-4-carboxylato-κ1O)-(μ2-oxalato-κ4
O:O′:O″:O‴)dioxidouranium(VI)], C16H11NO10U
Authors: Meng Yuning , Xie Ziyu , Lan Qiaofa , Niu Fei , Zhang Xiaolin , Yang Youming , Cai Bin
Published: December 2021

C16H11NO10U, monoclinic, P21/c (no. 14), a = 16.4675(12) Å, b = 11.7192(8) Å, c = 9.6663(7) Å, β = 100.823(2)°, V = 1832.3(2) Å3, Z = 4, R

gt
(F) = 0.0277, wR
ref(F2) = 0.0673, T = 170.0 K.
The Feelings We Feel: Care and Community in Mister Rogers’ Neighborhood
Authors: Valentine Riley
Published: December 2021

Mister Rogers’ Neighborhood was a show that focused on teaching children an ethics of caring for oneself and care for others. This article examines those ethics through the songs “I Like You As You Are” and “Won’t You Be My Neighbor.” It contends that these songs focus on a celebration of the self and others, welcoming individuals as they are into the community, and embracing authenticity. This article looks to understand these ethics in a contemporary setting and argues that Mister Rogers and the communal ethics of care that he taught are needed.
Hydrogen production via water splitting over graphitic carbon nitride (g-C3N4
)-based photocatalysis
Authors: Ismael Mohammed
Published: December 2021

Photocatalytic splitting of water into hydrogen and oxygen using semiconductor photocatalysts and light irradiation has been attracted much attention and considered to be an alternative for nonrenewable fossil fuel to solve environmental problems and energy crisis and also an as promising approach to produce clean, renewable hydrogen fuel. Owing to their various advantages such as low cost and environmental friendly, chemical, and thermal stability, appropriate band structure, graphitic carbon nitride (g-C3N4
) photocatalysts have gained multitudinous attention because of their great potential in solar fuels production and environmental remediation. However, due to its fast charge carrier’s recombination, low surface, and limited absorption of the visible light restrict their activity toward hydrogen evolution and numerous modification techniques were applied to solve these problems such as structural modification, metal/nonmetal doping, and noble metal loading, and coupling semiconductors. In this chapter, we summarize recent progress in the synthesis and characterization of the g-C3N4-based photocatalyst. Several modification methods used to enhance the photocatalytic hydrogen production of g-C3N4-based photocatalyst were also highlighted. This chapter ends with the future research and challenges of hydrogen production over g-C3N4-based photocatalyst.
The association between pain and central nervous system depressing medication among hospitalised Norwegian older adults
Authors: Bjelkarøy Maria Torheim , Cheng Socheat , Siddiqui Tahreem Ghazal , Benth Jūratė Šaltytė , Grambaite Ramune , Kristoffersen Espen Saxhaug , Lundqvist Christofer
Published: December 2021

Objectives

Central nervous system depressant medications (CNSD) including benzodiazepines, z-hypnotics and opioids are regularly prescribed for the older patient. These medications are linked to dependence and associated with severe side effects in some older patients. Consensus recommendations for this group suggest limiting their use. We have recently described a high proportion of long-term CNSD use and dependence among older in-hospital patients. In this study, we aim to investigate factors associated with pain intensity and presentation of pain among older adults with long-term use of CNSDs compared to non-users.

Methods

Two hundred and forty six elderly hospitalised patients were recruited consecutively in a cross-sectional study. Data was collected from patients and electronic health records (EHR). Independent variables were sex, age, education, emotional symptoms (hospital anxiety and depression scale [HADS]), cognitive function (Mini-mental State Examination test [MMSE]), comorbidity (cumulative illness rating score – geriatrics [CIRS-G]), loneliness (the six-item De Jong Gierveld Loneliness Scale) and prolonged (≥4 weeks) use of any CNSDs or prolonged use of opioids (≥4 weeks). All variables, including pain intensity, were collected at one time point consistent with the cross-sectional study design. Statistical analyses included descriptive statistics and linear regression models using the above mentioned variables and pain intensity (visual analogue scale for pain intensity [VAS] pain 0–100) as outcome. Additional information regarding pain presentation was extracted from the patients’ EHR.

Results

Mean pain intensity VAS (SD) was 35.2 (30.4) and 18.1 (24.2) respectively, for patients with vs. without prolonged use of CNSDs. In the multivariable linear regression analysis, prolonged use of CNSDs and opioids were positively associated with pain intensity (VAS) (regression coefficient (95% CI) 20.7 (11.0; 30.3), p<0.001, and 19.8 (5.7; 33.8), p=0.006, respectively), while sex, age, education, MMSE, HADS, CIRS-G and loneliness scores were not. Pain related to back (23.2%) and lower extremities (23.2%) were most common pain sites, and those with one or more pain sites reported overall higher pain intensity compared to those with no reported pain sites (p<0.006).

Conclusions

Prolonged use of CNSD medications as well as prolonged use of opioids are both positively associated with pain intensity. The results may have implications for treatment and long-term pain management for older patients.
Creating Atmospheric Coherence through Commemorative Rituals, Singing Partisan Songs, and Rehearsed Affect
Authors: Kovačič Mojca
Published: December 2021

U ovom se članku opisuje komemorativni događaj koji se održava u Janču pokraj Ljubljane te ga se smješta u širi okvir diskursa komemoracija u postsocijalističkom kontekstu u Sloveniji. Načini postizanja ritualizacije prošlosti i sadašnjosti te posredovanja između njih analiziraju se pomoću vizualnih i zvučnih sredstava stvaranja afektivnih
atmosfera. U tom je diskursu glazba sredstvo koje objedinjava kako sudionike događaja tako i odnose prošlosti prema sadašnjosti. Članak se bavi reaktualizacijom partizanskih pjesama u kontekstu zborskog pjevanja
nakon 1991. godine, a ističu se razlike između reaktualizacije kod aktivističkog i “tradicionalnog” zbora. Politička polarizacija utemeljena na različitim interpretacijama povijesnih događaja iz razdoblja tijekom i nakon Drugog svjetskog rata u postsocijalističkoj Sloveniji odražava se i u heterogenim iskustvima glazbenih izvedbi skladbi iz razdoblja narodnooslobodilačkog pokreta. Ta se tvrdnja ilustrira citatima iz osobnih narativa pjevača zbora Zora Janče sakupljenih nakon komemorativnog događaja. Narativi otkrivaju internu dinamiku koja se povezuje s osobnim doživljajem pjevanja kao i s odjecima kolektivnog pamćenja, prošlosti, povijesti, politike i osobnih iskustava. O heterogenosti doživljaja raspravlja se iz perspektive uloge
koju uvježbana ili simulirana afektivnost ima pri stvaranju koherentne afektivne atmosfere.
Čuvari marende
Authors: Ivanišević Jelena
Published: December 2021

Ovaj rad nastoji opisati i kontekstualizirati dio kulinarskih praksi muškaraca starije generacije na otoku Hvaru koje se ne realiziraju u okviru svakodnevice kućanskih poslova, nego kao dio društvenih praksi slobodnog vremena. Nasuprot rutinizirana i svakodnevna ženskog kuhanja koje se promatra unutar koncepta brižnog rada, ovakve muške kulinarske prakse pripadaju dokolici, no raspon značenja koja muškarci pridaju privatnom kuhanju velik je i višeznačan. Ne istražujući pomnije implikacije rodnih uloga u kuhinji, ovaj će rad nastojati osvijetliti muške kulinarske prakse i rituale, osobito one povezane s društvenim životom, a čiji se identitetski potencijal i važnost te značenje u prijenosu kulinarskog znanja sasvim previđaju.
Koreografisanje tradicionalnih plesova u sistemu komodifikujućih praksi
Authors: Rašić Miloš
Published: December 2021

Današnji srpski klubovi u Beču su kulturno-umetničke i sportske organizacije, proistekle iz nekadašnjih jugoslovenskih klubova koje su osnovali jugoslovenski gastarbajteri sedamdesetih godina XX veka. U početku, klubovi su svojim radom iskazivali pripadnost domovini, vodeći se ideologijom bratstva-jedinstva i iskazujući jugoslovenski identitet. Raspadom Jugoslavije, konfliktne nacionalne ideologije u zemlji matici uticale su i na klubove u dijaspori, pri čemu se oni dele prema nacionalno-etničkoj osnovi. Od devedesetih godina XX veka klubovi u Beču okreću se prezentaciji nacionalnog identiteta i nacionalnih programa, što je naročito vidljivo u radu folklornih sekcija. Cilj mi je da u ovom radu predstavim i analiziram jedan aspekt delovanja srpskih klubova u Beču – proces koreografisanja, koji ću tumačiti u sistemu komodifikujućih praksi. Polazim od hipoteze da, upravo zbog nacionalne ideologije i snažno prisutne nostalgije među srpskim migrantima u Beču, koreografi-amateri iz Srbije uspevaju da održe “tržište” svojih koreografija, predstavljajući ih kao “autentične” produkte kojima se “čuva tradicija” zemlje matice. Rad je podeljen u dve veće celine: 1) etnografski prikaz procesa koreografisanja i pitanja njegove autentičnosti; 2) analiza procesa komodifikacije plesa i koreografija.
Evaluation of Soil Strength from Variable Rate CPTU Tests in Silt
Authors: Bihs Annika , Long Mike , Nordal Steinar
Published: December 2021

The interpretation of cone penetration test (CPTU), at the standard rate of 20 mm/s, results in clays assuming undrained penetration tests, whereas the interpretation in sands is carried out using a drained approach. However, for silts, the drainage conditions during a standard rate test are less well understood, and often partial drainage occurs. The main objectives of this work are to show the limitations of applying existing correlations for sand and clay to a silt material and to give guidance to practicing engineers on how to establish strength parameters for silts that allow a safe design. This paper presents the results of a comprehensive laboratory and field test study that was carried out on a silt site in Halsen-Stjørdal, Norway. Varied rate CPTU tests were conducted, and various soil samples were taken. Using a conventional Nkt approach to determine undrained shear strength, standard rate CPTU tests provided 20 % higher values compared with high-rate tests. Thus, the undrained strength may be overestimated from standard rate tests. Care needs to be taken when using undrained shear strength in silts. Nevertheless, this value represents a limiting strength value, which is often of interest when investigating the response as if it were undrained. The friction angle could be successfully determined from CPTU results by applying the modified Norwegian Institute of Technology (NTH) method to the measured data set. The results reveal a rate dependency of the friction angle, resulting in an underestimation of 20 % if a standard rate test is used compared with using low-rate CPTU tests, giving drained results that match the reference values from the laboratory. To overcome uncertainties in picking design strength values, it is highly recommended to carry out at least one fast and one slow CPTU test to evaluate the drainage situation and to adjust the design values accordingly.
Distinct Progressions of Neuronal Activity Changes Underlie the Formation and Consolidation of a Gustatory Associative Memory
Authors: Arieli Elor , Younis Nadia , Moran Anan
Published: December 2021

Acquiring new memories is a multistage process. Numerous studies have convincingly demonstrated that initially acquired memories are labile and are stabilized only by later consolidation processes. These multiple phases of memory formation are known to involve modification of both cellular excitability and synaptic connectivity, which in turn change neuronal activity at both the single neuron and ensemble levels. However, the specific mapping between the known phases of memory and the changes in neuronal activity at different organizational levels—the single-neuron, population representations, and ensemble-state dynamics—remains unknown. Here we address this issue in the context of conditioned taste aversion learning by continuously tracking gustatory cortex neuronal taste responses in alert male and female rats during the 24 h following a taste–malaise pairing. We found that the progression of activity changes depends on the neuronal organizational level: whereas the population response changed continuously, the population mean response amplitude and the number of taste-responsive neurons only increased during the acquisition and consolidation phases. In addition, the known quickening of the ensemble-state dynamics associated with the faster rejection of harmful foods appeared only after consolidation. Overall, these results demonstrate how complex dynamics in the different representational levels of cortical activity underlie the formation and stabilization of memory within the cortex.

SIGNIFICANCE STATEMENTMemory formation is a multiphased process; early acquired memories are labile and consolidate to their stable forms over hours and days. The progression of memory is assumed to be supported by changes in neuronal activity, but the mapping between memory phases and neuronal activity changes remains elusive. Here we tracked cortical neuronal activity over 24 h as rats acquired and consolidated a taste–malaise association memory, and found specific differences between the progression at the single-neuron and populations levels. These results demonstrate how balanced changes on the single-neuron level lead to changes in the network-level representation and dynamics required for the stabilization of memories.
MAWAR (Melawan Rentenir): Integrated MSMEs Financial Inclusion Strategy In Sharia-Based
Authors: Chasanah Amalia Nur , Herawati Ratna , Budiantoro Risanda Alirasta , Sukono Putro Febrianur Ibnu Fitroh
Published: December 2021

Allah has provided Islam as life guidance to be used in taking and undergoing all life aspects, including of the management and business financing. In the perspective of Islamic finance, financing venture capital through moneylenders will makes the borrower in difficult situation. This research aims to analyze the integrated financial inclusion strategy in sharia-based MSMEs financing in the Semarang City with the MAWAR Program. Mawar program is a funding assistance program for potential micro small andÂ  medium entrepreneurs based on sharia with Murabahah by collaborating through memorandum of understanding with several other agencies, such as Sharia People Financing banks, Semarang City Amil Zakat Agency, Semarang Syariah Economic Community, Semarang City Cooperatives and Micro Enterprises Agency, telecommunications companies, branchless banking agents and financial technology institutions. The benefit obtained can provide scientific contributions to the empowerment management and can be developed into a study material for long-term planning programs by the Semarang City Government in empowering micro, small and medium enterprises so they can be competitive, independent, prosperous, and cultured based on religiosity values. The approach method used qualitative research with analytical tools is the business model canvas. Data collection method used observation, interviews, and literature study. The results of this research are with the MAWAR Program, the Semarang City Government does not charge any additional costs to the borrowers (MSMEs). The legal basis of this program is based on a memorandum of understanding between the stakeholders involved and Islamic sharia
Bank Branch Closure Assessment Using DEA
Authors: Parsaulian Renata , Chalid Dony Abdul
Published: December 2021

The downward trend in the number of commercial bank offices is driven by the bank's efforts to shift banking transactions from physical branch to digital channels in order to improve efficiency. In prioritizing the branch closure, bank needs to define the appropriate method used in the analysis. This case study is intended to identify the parameter to determine the prioritization of bank branch office closure. This study uses a non-parametric approach of Data Envelopment Analysis (DEA) to examine the efficiency and productivity change of branch offices at one of the large bank in Indonesia. The one-stage DEA was used to generate the relative efficiency score, and the input-oriented Variable Return to Scale (VRS) assumption is adopted in data analysis based on the production approach. The Malmquist Productivity Index was also adopted to measure the total factor productivity change. The DEA result shows that a number of closed branches in 2019 and 2020 were actually considered efficient, with increasing productivity, compared to many other inefficient branches. The efficiency and productivity score can be further used by the bankâ€™s management to evaluate the upcoming branch closure as well as the overall branches efficiency.
Dynamic Forecasting of Government Foreign Debt: Case of Indonesia
Authors: Rahman Yozi Aulia , Pujiati Amin
Published: December 2021

This study aims to forecast the value of the Indonesian government foreign debt in 2020-2024. The secondary data of time series during the period of 2010-2019 on Indonesian government foreign debt are used as the basis of forecasting for the next five years by using ARIMA (Autogressive Integrated Moving Average). The results show that the selected ARIMA models for forecasting are ARIMA (3,1,3) after the unit root test is carried out and 16 ARIMA models are tested. The value of government foreign debt is predicted to keep increasing from 2020 to 2024 amounted to USD 253.01. Then, compared to government debt in January 2010, within 11 years, government foreignÂ  debt is predicted to rise by 169.6%.
Corruption and Economic Growth at Province Levels in Indonesia
Authors: Nairobi Nairobi
Published: December 2021

This study aims to determine the effect of corruption on economic growth at the provincial level in Indonesia. This study uses a model based on the economic growth model of Levine and Renelt (1992). This study uses secondary data obtained from the Central Statistics Agency (BPS), the Investment Coordinating Board (BKPM), and Transparency International Indonesia with the research period of 2014-2018. This study uses a panel data model with a cross-section of 16 (sixteen) provinces in Indonesia. This study uses a model with a Random Effect Model (REM) approach. The results showed that the corruption perception index, foreign direct investment (FDI), initial growth (EGt-1), government spending (GE) and labor (L) each had a positive and significant effect on economic growth (EG) in 16 provinces in Indonesia for the 2014-2018 period, ceteris paribus.
Why Does Indonesia Have a High Covid-19 Case-Fatality Rate?
Authors: Karnadi Erwin Bramana , Kusumahadi Teresia Angelia
Published: December 2021

The COVID-19 pandemic has taken the world by storm, but the magnitude of its impact differs from country to country. As of August 2020, Indonesia’s COVID-19 case-fatality rate is higher than the world average. The aim of our research is to find out why Indonesia has a high COVID-19 case-fatality rate. Using OLS regression models, we found the number of COVID-19 related deaths, the number of COVID-19 tests performed, population age, population, voice and accountability index, and control of corruption index are significant predictors of a country’s COVID-19 case-fatality rate. Based on our results, we conclude that Indonesia’s COVID-19 case-fatality rate is higher than it is supposed to be, mainly because of a lack of COVID-19 testing and accurate public information.
Registers of Healthcare Systems of Northen European Countries
Authors: PUHACHOVA M. V. , GLADUN О. М.
Published: December 2021

The introduction of electronic register systems for all spheres of state functioning is becoming more widespread in developed countries. It is the systems, not individual registers, that create the conditions for the comprehensive and effective use of available information in the field of state and local government, research, business planning, and so on. In our opinion, health care registries are the most important among other systems, so it is important to study the experience of the most developed countries in the field of creating electronic medical information resources. The use of the experience gained by advanced European countries in this area is especially useful for Ukraine, where such a system is being developed. The purpose of the article is to summarize the experience of Northern European countries in the use of electronic information resources of health care for its implementation in Ukraine. The novelty of the article is a generalized and comparative analysis of health registry systems in Denmark, Norway, the Netherlands, Estonia, Sweden, Finland and a study of the role of medical, statistical and scientific institutions in the development of these systems. The research methodology is based on the application of the following methods: system analysis, scientific generalization, comparative analysis, research methods of complex systems. The article examines the health care systems of six northern European countries, compares the composition and features of these systems. The focus is on electronic information resources, which are introduced only in some countries. It is established that the Danish and Norwegian systems are the most branched among the systems of other studied countries and contain not only a larger number of specialized registers, but also have the largest number of organizations that maintain these registers. The holders of registers and databases in different countries are not only the relevant ministries but also research institutes and universities. In addition, statistical authorities also create registers that are used for society’s statistical information needs. The study thus summarizes the experience of creating and operating electronic information resources in the field of health care in Northern European countries, concludes that it can be used in the implementation of a similar Ukrainian, the process of which began several years ago.
Education in the Pandemic
Authors: NOVIKOV V. M.
Published: December 2021

The education sector in Ukraine, as in most other countries of the world, is facing a global challenge due to the spread of the coronavirus SARS-CoV-2. Educational institutions are in an emergency situation and are forced to switch to distance or mixed learning. As a result, there were difficulties with the implementation of a new alternative model, according to which educational institutions have started to work and provide a wide range of their services. The purpose and novelty of the article is a systematic generalization of the results of the extreme mode of operation of educational institutions during the pandemic to adapt them to the extraordinary situation of functioning and further development. The method of research is the systematization of empirical data on individual practices of different types of educational institutions and, on this ground, determination of the possibility of combining in a holistic operation mechanism in terms of the social justice and effi ciency principles. Th e article analyzes the readiness of the education system for distance learning in the context of a pandemic, determines positions for the regulation and sustainable adjustment of educational institutions, ensuring fair access for various segments of society to online resources, the formation of positive scenarios for the education functioning in the epidemic and post-epidemic period. The paper uses the main theoretical positions formulated in the monograph “COVID 19. Great Overload” by Klaus Schwab, economist, founder and president of the World Economic Forum in Davos since 1971, and his co-author Thierry Muller, a publicist and researcher. One of the main provisions concerning education and its long-term development is that the current crisis is forcing society to realize that most decisions are based on moral and fair choices, and that in the future it is possible to move away from personal interests and create a more harmonious society. The UN materials on the analysis of the COVID-19 consequences for the education system and its reconstruction in the future are also used. The study identifies the dynamics of processes throughout the pandemic. Positive and problematic practices are given. The findings obtained from research and experience can be the basis for developing measures to help education institutions to overcome the “transition period”. The key factors of their stability are the general education services (digital libraries, online education platforms), mobilization of teaching and student contingents to work in new conditions, compliance of financial and distribution mechanisms with the requirements of the time.
ТРАНСФОРМАЦІЇ ТУРИСТИЧНОЇ СИСТЕМИ В УМОВАХ ЦИФРОВІЗАЦІЇ
Authors: МАЗАРАКІ Анатолій , БОЙКО Маргарита , ОХРІМЕНКО Алла
Published: December 2021

Туристична система за рахунок мультиплікаційного ефекту спроможна забезпечити зростання суміжних галузей і стати передумовою позитивних соціо-еколого-економічних процесів. Значний вплив на туристичну систему здійснила світова пандемія COVID-19, яка спричинила низку негативних явищ у функціонуванні цього сектору економіки. Необхідність вирішення стратегічних проблем у розвитку туристичної системи зумовлює потребу в дослідженні трансформаційних змін, що відбуваються в ній.Обґрунтовано соціально-економічні трансформації в туристичній системі, запропоновано необхідні заходи щодо посилення позитивного і нівелювання негативного впливу зовнішнього середовища в умовах нової реальності та цифровізації. На основі аналізу динаміки показників діяльності суб'єктів туристичного і готельного секторів як базових складових туристичної системи виявлено асиметрії розвитку, які зведено в три групи: функціональні, структурні й часові. Відображено часові й структурні параметри транзитивності, обґрунтовано її прояви через прогресивну і регресивну динаміку процесів розвитку туристичної системи України. Визначено стадії еволюції туристичної системи (адаптаційну, знаннєвоорієнтовану, інтеграційну) й обґрунтовано нову – цифрову і мобільну. Запропоновано впровадження інноваційних домінант у туристичній системі України як драйверів стратегічного розвитку. Зазначені інноваційні домінанти зосереджено за напрямами: цифровим, комунікативним, партнерським, екологічним і фінансовим. Особливу увагу приділено впливу цифрових змін на трансформацію туристичної системи та її складових. Актуалізація інноваційних домінант у туристичній системі України, з одного боку, відображає глобальні суспільні тренди і коригується чинниками інституційного середовища та національного менталітету, а з іншого – спричинена зміною споживчих переваг і виникненням нового середовища розвитку туристичної системи.
ПРОВАЛИ ДЕРЖАВНОГО РЕГУЛЮВАННЯ НА РИНКУ ПРАЦІ ТА МОЖЛИВОСТІ ЇХ МІНІМІЗАЦІЇ
Authors: БЛИЗНЮК Вікторія , ГУК Лариса
Published: December 2021

Міжнародна співпраця, розбудова цифрової економіки і глобалізація ринків, у тому числі й ринку праці, стали причиною перерозподілу виробництв і трансформації сфери зайнятості. Національний ринок праці перебуває під впливом комбінованих тенденцій, які викликають неоднозначні ефекти для його інституційних суб’єктів. Держава стикається з низкою проблем, що гальмують формування такого ринку праці, який би відповідав сучасним економічним вимогам і соціальним викликам.Вивчено провали державного регулювання ринку праці та узагальнено їх за блоками; висвітлено за кожною групою (блоком) основні проблеми, вирішення яких визначатиме стратегічні напрями державної політики у сфері зайнятості. Використано такі методи дослідження, як системний аналіз, компаративний аналіз, структурно-функціональний аналіз, метод статистичних групувань, експертні оцінки тощо.Розглянуто систему провалів державного регулювання ринку праці. Її структуровано за узагальненими групами: інерційність розвитку і архаїчність структури зайнятості; атиповість адаптації ринку праці; диспропорційність попиту і пропозиції робочої сили; деструкція соціального діалогу на ринку праці; дохідна нерівність; низький рівень інфорсменту трудового законодавства. Для кожної групи, що характеризує провали державного регулювання ринку праці, визначено чинники формування, особливості прояву, можливі негативні наслідки й способи пом’якшення їх дії та шляхи виходу з них.Запропоновано напрями державної політики у сфері зайнятості, які формуватимуть унікальну можливість розпочати діяти по-новому, віддаючи пріоритет новим складовим, принципам, правилам взаємодії на ринку праці в умовах нестабільності та перманентної кризи. Підкреслено важливість цілепокладання стратегічного курсу державного регулювання відповідно до окреслених узагальнених груп, що визначає прояви дивергентності українського та європейського ринків праці.
Research of German Classical Philosophy at the Institute of Philosophy
Authors: Terletsky Vitalii
Published: December 2021

The article analyzes the work of the staff of the Institute of Philosophy of the Academy of Sciences of Ukraine, which relates to the study of German classical philosophy. Ideologically unbiased studies of German idealism at the Institute became possible only after it was headed by Pavlo Kopnin. The Taras Shevchenko University of Kyiv became the center from which all researchers of German idealism emerged in the first half of the 1960’s. At first more attention was paid to Hegel’s philosophical system, which was reflected in the monograph of V. Shinkaruk (1964). In the mid-1970’s, Kant’s critical philosophy came to the fore, various aspects of which were analyzed in the collective monograph “Critical Essays on Kant’s Philosophy” (1975). In the early 1980’s, researchers engaged intensively in Feuerbach’s “anthropological materialism” by publishing the collective monograph “Essays on Feuerbach’s Philosophy” (1982). The works and ideas of Hegel, Kant and Feuerbach were the main subject of attention of researchers at the Institute, which was reflected in numerous publications in the journal “Philosophical Thought”. Instead, Schelling’s philosophical systems, and especially Fichte’s, remained almost neglected until 1991.