bluuebunny/crossref_metadata_2025 huggingface dataset:
RECIPIENT FACTOR IN POETIC TRANSLATION DIACHRONY
Authors: Filippova Irina Nikolaevna
Published: October 2019

The paper's aim is to analyze transchronical interlingual and intercultural poetic communication. Special attention is paid to the recipient, his significance in diachronic translation is investigated. Linguistic and cultural aspects of poetic communication are analyzed: realities, historicisms, archaisms, phraseological units, allusions. The recipient factor is actively studied in pragmalinguistics, which finds common ground with translation studies and the theory of intercultural communication. The research is based on the integrative method: descriptive, contextual, comparative and discursive analysis are used. The paper reveals the synergetic nature of the recipient, unique on age, gender, worldview, political and cultural characteristics; cognitive dissonance of the author and the recipient in monolingual and in interlanguage communication are revealed. The actual basis is the novel in verse Pushkin “Eugene Onegin”, written almost 200 years ago and numerous translations made at different times (1840-2008). The studied empirical material leads to the following conclusions. The translation multiplicity in transchronical transfer of cultural heritage to foreign languages is natural and unavoidable. The search for adequate means of intercultural translation of poetry is transcendental in nature. The syncretic nature of the poetic sign in diachrony strengthens the discrepancy between the recipient's and the author's conceptual and thematic knowledge content. This is particularly evident in terms of the transf chronic communication when the author and recipient are separated by a significant time interval. The source language recipients and the target language recipients have objective sociocultural differences which are more evident in transtemporal interlingual communication. The above-mentioned factors interact in the complex synergistic system that is impossible to cognize and to describe in a reductive linguistic theory of translation. On the basis of insufficiency of the reductionism of the linguistic translation, can be expected the transition to the methodology of holism translation. Holism as a methodological principle and philosophy of knowledge has found effective application in the Humanities. Its use in translation in cross-cultural, cross-language and TRANS chronic communication appear to be objectively necessary. The need for pragmatic adaptation and the borders of its approximate values is to be verified in further studies, combining pragmalinguistics, cognitive linguistics, translation studies, functional stylistics, discourse analysis and linguocognitive translation.
CLASSIFICATION OF PREPOSITIONS OF STORY GENRE AS A WORK OF FICTION (on Material of A.S. Pushkin’s Story “The Queen of Spades” in Russian and English)
Authors: Semenova Sofiya Novikovna
Published: October 2019

The article presents the prepositions’ classification. The aim of the research is to classify prepositions by types and frequency use (quantitative and percentage ratio) in the story genre as a work of fiction (on A. S. Pushkin’s story “The Queen of Spades” in Russian and English). To achieve the goal, it was necessary to solve the following tasks: 1) to study “The Queen of Spades” in Russian and English; 2) to make tables on the prepositions’ types; 3) to build diagrams on the prepositions’ types; 4) to describe the collected information. The author used in the material research: 1) component analysis method; 1. quantitative calculation method; 3) percentage calculation method; 4) classification method. In the course of studying the Russian version there are found prepositions that serve to express such relationship as: spatial, temporal, causal, target, mode of action and object; in English: prepositions of abstract relations (genitive case, dative case, instrumental case, prepositional case, accusative case), spatial, phrasal verbs, temporal, complex prepositions, causal and target. The found prepositions serve as a sample of bilingual texts for discursive activities not only for specialists, but also for those who are interested in problems related to prepositions in Russian and English. According to the study, it can be concluded that a detailed analysis of the tables and diagrams revealed the main characteristics of prepositions, making it possible to distribute them into appropriate groups; to find the main similarities between groups of English and Russian prepositions, as well as the differences between them.
US-VERSUS-THEM POLARIZATION IN THE US PRESIDENTIAL DEBATES OF 2000
Authors: Mukhortov Denis S. , Zhovner Elizaveta A.
Published: October 2019

Political discourse as a specific sign system in which the meaning depends on the speaker’s intention tends to portray participants in terms of “us” versus “them”, which makes “us-versus-them” polarization one of the main distinguishing features of political discourse. The onset of the 21st century is a turning point in the history of geopolitics, which requires politicians to be more creative in search of vote-winning means. The pragmasemantic approach allows to study presidential debates between 1. Bush and Al Gore from the standpoint of semantics which studies meaning and which has been recently affected by pragmatics that deals with non-linguistic aspects of meaning such as the context of a situation and the speaker’s intention. The presidential debates of 2000 are a vivid illustration of how two opposing politicians strive to share the same objective though different language means. The contentanalysis program LIWC (Linguistic Inquiry and Word Count) was used in order to verify the results of research. The analysis of Pronouns, Positive/Negative Emotions, and Tense Focus through LIWC makes a contribution to political discourse studies. This article illustrate how various language means such as use of pronouns “we” and “they”, specific vocabulary and slogans, when grouped together, can appear to be an efficient research tactic.
ADDRESS FORM AS A REFLECTION OF ETHNO-CULTURAL STYLE OF COMMUNICATION (based on British and Canadian English)
Authors: Yuryeva Yulia B.
Published: October 2019

Culture and the process of communication are interrelated, since culture not only indicates between which members of the society a communication act is possible, but also helps to decode correctly the meaning of the message that was encoded, and also according to what conditions the message would be correctly interpreted by the interlocutor. The historically established ethno-cultural style of communication (T. Larina) reflects the communicative peculiarities of people’s behavior when choosing verbal and non-verbal means in the process of communication. The article is devoted to sociocultural features that influence the choice of language means for expressing an initial speech formula. The aim of our research is to examine address forms in the boundaries of one language but in two different countries (Canada, Great Britain) with their historical and cultural background. We draw on Cultural Dimensions of G. Hofstede (1991), the Theory of Politeness (Brown & Levinson 1987, Leech 2014), the background of Intercultural Pragmatics (A. Wierzbicka 2003, I. Kecskes 2014), Speech Accommodation Theory (Giles 1977) and etc. The article presents the results of the study on the usage of address forms among the representatives of British English (BrE) and Canadian English (CanE) in order to identify similarities and differences and to explain the results according to cultural characteristics.
Embolización venosa transcateter de várices gástricas con coils
Authors: Rivero Rapalino Oscar , Barragán Leal Camilo , Salcedo Miranda Diego , Quintero Rojas Laura
Published: October 2019

Los espirales de embolización (coils o microcoils) son los agentes más comúnmente usados, con un éxito técnico reportado en aproximadamente el 81-100 % de los casos. Los espirales o coils se encuentran disponibles en una amplia variedad de configuraciones y tamaños, lo que permite acomodarse a vasos de distintos calibres; además, por su buena radiopacidad, tienen la ventaja de ser liberados con precisión. Los espirales o coils son el análogo de una ligadura arterial quirúrgica, debido a que producen una oclusión mecánica por su posicionamiento en el lumen vascular, lo que disminuye el flujo sanguíneo, y sus fibras sintéticas tienen un efecto trombogénico adicional.
Caso: presentamos cuatro casos del Hospital Universitario Fundación Santa Fe de pacientes con várices gástricas tratadas satisfactoriamente con embolización transcatéter con coils, los cuales tuvieron un buen resultado técnico; además presentamos una revisión de la literatura.
Heterotopia de mucosa gástrica en intestino delgado, hallazgo en videocápsula endoscópica. Reporte de caso
Authors: Castaño Santiago , Calvache Natalia , Sepúlveda Mauricio
Published: October 2019

Resumen

Introducción: La heterotopia de mucosa gástrica, hace referencia a la localización ectópica de mucosa gástrica en cualquier parte del tracto gastrointestinal. Es una causa poco frecuente de úlceras gastrointestinales y sangrado digestivo oculto. La videocápsula endoscópica se ha convertido en una herramienta fundamental para el estudio del intestino delgado.

Métodos: Estudio descriptivo de reporte de caso. La información de la historia clínica, reporte de patología y estudios endoscópicos, se extrajo desde las bases de datos de la Fundación Valle del Lili.

Resultados: Paciente masculino de 71 años, en quien se realizó videocápsula endoscópica por sangrado digestivo oculto y se encontraron segmentos de estenosis y úlceras en yeyuno. La histopatología reveló la presencia de mucosa gástrica heterotópica.

Conclusión: La heterotopia de mucosa gástrica debe ser pensada como causa de posible sangrado de intestino delgado.
Prevalencia de enfermedad por reflujo gastroesofágico por pHmetría en recién nacidos prematuros con síntomas sugestivos
Authors: Velasco-Benitez Carlos Alberto , Vallejo-Mondragón Ernesto León , Arévalo-Sanabria Mauricio Alberto
Published: October 2019

Introducción: el reflujo gastroesofágico (RGE), fenómeno fisiológico común en recién nacidos pretérminos (RNPreT), se diagnostica frecuentemente en neonatos, convirtiéndose en un importante fenómeno clínico en pretérminos.
Objetivo: determinar la prevalencia y los síntomas de enfermedad por RGE (ERGE) por pH-metría intraesofágica ambulatoria de 24 horas (pHm) en pretérminos.
Metodología: estudio de prevalencia en pretérminos de una unidad de cuidados intensivos neonatales de Cali, Colombia a quienes, por sospecha clínica de ERGE, se les solicitó una pHm, teniendo en cuenta variables sociodemográficas y clínicas. La estadística incluyó un análisis univariado por medio de medidas de tendencia central y análisis bivariado con la prueba de chi cuadrado (χ2) y la t de student, siendo significativa una p <0,05.
Resultados: se analizaron 20 RNPreT de 36,5 + 27,6 días de edad postnatal; de 31,6 + 3,8 semanas de edad gestacional; 12 masculinos. 11 RNPreT (55,0 %) presentaron una pHm anormal. La presencia de residuos y cardiopatía estuvieron asociados con pHm anormal.
Conclusión: La ERGE por pHm en los RNPreT estudiados tiene una prevalencia relativamente alta en comparación con la literatura mundial, sin encontrar una franca asociación con los síntomas analizados, a excepción de cardiopatía y residuos gástricos.
Rol de los antiespasmódicos en el manejo del síndrome de intestino irritable
Authors: Costa Valeria Atenea , Ovalle Hernández Alan Felipe
Published: October 2019

El uso de los antiespasmódicos forma parte de la piedra angular del tratamiento en el síndrome de intestino irritable (SII), independientemente del subtipo. Consideramos relevante hacer una revisión de los medicamentos antiespasmódicos disponibles actualmente en Colombia, los cuales son usados crónicamente, de manera frecuente, en esta enfermedad.
Arnavutça Konuşma Dilinde Türkizmalar: Kosova Sözlü Tarihi Örneği
Authors: Xhafçe Zeqije
Published: October 2019

Bir sözcüğün farklı bağlam ve durumlarda, farklı dil kesitlerinde farklı anlamlar alabileceği, modern dilbiliminde kanıtlanan bir gerçektir. Kesit dillerini toplumdilbilimine yerleştirmeye çalışan Biber (1994) kesit dillerinin yazılı ve sözlü olmak üzere de iki ayrı sınıfa ayrılmasının önemini vurgularken birçok toplum dilbilimcinin konuşma dilinin dilin temel şekli olduğunu savunduğunu söylemektedir. Bu tespitlerin ışığında, Arnavutça sözcükleriyle değiştirilmesi gereken yabancı sözcükler olarak nitelendirilen ve Türkizma adıyla bilinen sözcüklerin konuşma dilinde ve diğer kesit dillerindeki kullanımı ele alındı. Arnavutça sözvarlığının tarih, kültür ve dil açısından önemli bir parçası olan türkizmaların genel olarak konuşma ve özel olarak diğer kesit dillerindeki kullanımının incelenmesi yapılmadan konumları hakkında doğru bilginin edinemeyeceğini düşünüyoruz. Dolayısıyla, çalışmamızda 100’e yakın konuşmacının yer aldığı Kosova Sözlü Tarihi projesinin videoları esas alınarak, türkizmaların konuşma dilindeki kullanımları incelendi. Toplumdilbilimsel yöntemleri ile türkizmaların kullanım sıklığı, konu odaklı kategorilerdeki dağılımı ele alındı, nicel ve nitel incelemesi yapıldı. 19. yüzyılın ilk yarısından bu yana pürizm konusu olan türkizmaların Arnavutçadaki güncel konumu tespit edilmeye çalışıldı. Arnavutçada yer alan türkizmaların istergüçlü bir deyiş/biçem aracı olarak kullanımı ister Arnavut sözvarlığının aktif unsuru olup olmadığı modern dilbilim yöntemleri uygulanarak araştırıldı.
Taita Imbabura: Reverence And Mirth In Mountain Worship
Authors: Holmes McDowell John
Published: October 2019

Dedication
I dedicate this essay to my good friend and longtime colleague at Indiana University, Ilhan Basgoz. I have learned much from Ilhan, an astute student of culture, in particular, of narratives and the ways they shape people’s understandings of the world. I believe that the theme I develop in this essay, having to do with stories and systems of belief in an Andean society where I had the privilege to do ethnographic research, owes much to Ilhan’s influence on my thinking and scholarship.
"Smuggling A Dangerous Cargo": Discovery of a Hidden Treasure
Authors: Danesgar Shahyar
Published: October 2019

For those who have made the study of the folklore of the Turkish and Turkic world their focus, the name Professor Ilhan Başgöz is not unfamiliar. Professor Başgöz is among the best-known scholars of Turkish folklore. He has devoted his entire life to the study of
folklore internationally and Turkish folkloric materials specifically.
Perfil profesional del revisor fiscal y el auditor respecto a la NIA 500
Authors: Díaz Castro Javier , Parrado Rincon Whiter Smith , Moya Martínez Sary Estefany , Saénz Peña Karent Jouliet , Cepeda Vigoya María Paula
Published: October 2019

El estudio de la NIA 500 y el perfil profesional del revisor fiscal y el auditor en ésta, se ha dividido en dos ámbitos principales, uno relacionado con su función procedimental en la Auditoría y otro orientado en el perfil profesional, el cual hace referencia a las aptitudes que deberá adquirir el auditor para cumplir con lo establecido por la normatividad a entrar en vigor. Justificación: la realización de éste estudio surge con la intención de indagar a cerca del nivel de actualización y capacitación en el ejercicio de la profesión. Tiene una connotación teórico-práctica.  Antecedentes: a nivel Latinoamérica se denota un desarrollo normativo superior en países como México y Costa Rica, Colombia por su parte, se encuentra en periodo de transición y preparación al respecto. Metodología: implementa un diseño no experimental de corte transversal, es de alcance descriptivo y de tipo documental y correlacional. Resultados: se muestra el análisis de la información de manera gráfica y el estudio entre las variables de correlación. Conclusiones: al trabajo investigativo se le atribuye comprensivo, coherente y pertinente como instrumento en el proceso de capacitación y actualización de la profesión.
Efectos en los estados financieros de la implementación de la gestión ambiental en el molino industrial arrocera superior limitada
Authors: Martínez Carolina Esther , Ortiz Moreno Gina Zoraida , Hernández Gonzalez José William
Published: October 2019

El Molino Industria Arrocera Superior LTDA, no tiene creado el Departamento de Gestión Ambiental DGA para dirigir la gestión ambiental como lo exige la Ley 1124 de 2007 y el Decreto 1299 de 2008, que permita velar por el cumplimiento de la normatividad ambiental; prevenir, minimizar y controlar la generación de cargas contaminantes hacia el entorno. Esta problemática le genera a la empresa, una serie de situaciones adversas que afecta su desarrollo organizacional y además puede acarrearle posibles sanciones por el incumplimiento de las normas. Por lo anterior, el estudio tiene como objetivo, determinar los efectos en los estados financieros que podrían darse por la implementación de la gestión ambiental en la empresa. Se empleó la investigación descriptiva, con la cual se reseñó la información recolectada a través de encuestas, libros y documentos relacionados con el tema. Resultados. El 80% de los encuestados, dicen que existe incumplimiento en leyes ambientales, como la que exige la creación del DGA y la implementación del sistema de gestión ambiental; y un 60% dice que esto se debe a la falta de capacitación del personal y al desarrollo de una gestión que permita mitigar los efectos negativos hacia el medio ambiente, por las actividades. Se concluyó que la empresa no realiza un proceso de gestión ambiental mediante un departamento especializado como lo exige la ley; y que, al proyectar su implementación, se concluyó que trae efectos para el crecimiento empresarial.
Estudio salarial de las micro y pequeñas empresas del municipio de Restrepo, Meta, Colombia
Authors: Torres-Flórez Dagoberto , Dasilva Patría Aldair , Mogollón Parra Gisela , Montaño Jeison Julian , Rojas Orson Stiven
Published: October 2019

Este artículo presenta los resultados de la investigación realizada al sistema de compensación salarial de las micro y pequeñas empresas del municipio de Restrepo-Meta; los hallazgos serán de utilidad para la comunidad empresarial porque fortalece sus conocimientos frente los sistemas de compensación. Para el desarrollo de esta investigación se aplicó un instrumento que contenía preguntas referentes a la contratación, el salario, los aumentos salariales e incentivos. En cuanto a los resultados, en la contratación se pudo determinar que el tipo de contrato más usado es el verbal, el cual se utiliza para vincular laboralmente personal de tiempo completo y en la mayoría de los casos dicho contrato termina por la decisión de alguna de las partes. En lo que respecta a los salarios se encontró principalmente que un poco más de la mitad paga un SMMLV, este salario es fijo, pagado quincenalmente y en efectivo, y su establecimiento en su mayoría es por criterio personal, es decir del propietario. Frente a los aumentos salariales se encontró que un poco menos de la mitad no realizan ningún aumento salarial, y para quienes lo realizan, el factor más influyente al momento de determinarlo es el desempeño del trabajador. Y por último, sobre los incentivos laborales se pudo concluir que estos se otorgan principalmente por el cumplimiento de metas y fechas especiales; y los otorgados con una mayor frecuencia son tiempo y dinero.
Rol del contador público de los institutos descentralizados de Villavicencio en adaptación de procesos contables bajo la NTCGP 1000:2009
Authors: Álvarez González Lina , León Machado Lizeth
Published: October 2019

Ante los actuales requerimientos normativos en la gestión pública, las entidades y empresas del Estado deben adoptar sistemas de gestión de calidad acordes a la Norma Técnica Colombiana NTCGP 1000:2009; entre los profesionales que están llamados a contribuir a esa gestión se encuentran los Contadores Públicos, por lo cual se adelantó un estudio tendiente a identificar el rol del Contador Público en la implementación y/o mejoramiento de los procesos contables en los institutos descentralizados municipales de Villavicencio acorde a la NTCGP 1000:2009.

Se realizó un estudio de tipo descriptivo, apoyado en el enfoque mixto (cuali-cuantitativo), tomado como población a los siete institutos descentralizados del municipio de Villavicencio, aunque se manejaron dos muestras. La primera de ellas fue representada por los siete contadores públicos que ejercen como auditor interno en los institutos objeto de estudio. La segunda muestra fue formada por catorce Contadores Públicos que laboran en estos institutos (dos por cada instituto), a quienes se les aplicó un formato de encuesta.  

Los resultados obtenidos permitieron establecer el rol del auditor interno en la implementación y/o mejoramiento de los procesos contables en los institutos objeto de estudio en función a la aplicación de la NTCGP 1000:2009, al igual que determinar las funciones desarrolladas por el Contador Público para el mismo caso. Finalmente se analiza el papel del Contador Público en la aplicación de la gestión de calidad.
La integración de las comunicaciones de marketing como núcleo de las comunicaciones de marca
Authors: Tunaroza Juan David , Rojas Torres Diana
Published: October 2019

El presente artículo expone algunas perspectivas del concepto de las Comunicaciones Integradas de Marketing (CIM), resaltando éstas como un aspecto fundamental en todo proceso de comunicación y gestión de marca. Se parte de la interrelación entre los clientes y las compañías junto con la tecnología y los consumidores. Treinta años después de la aparición de una de sus primeras definiciones las Comunicaciones Integradas de Marketing aún son un tema de discusión en la academia y en la práctica. Sin embargo, continúan su desarrollo e implementación alrededor del mundo.

La literatura abordada sugiere la búsqueda de un común acuerdo a partir de su estructura teórica inicial junto con el desarrollo de una visión holística del marketing en el entorno, haciendo un llamado a desarrollar nuevas y diferentes maneras de sinergizar las dinámicas entre miembros de una misma compañía, integrando los aspectos estratégicos y operativos con el fin de dirigir la esencia y mensajes de marca para incrementar su valor.
The effect of fibrinolytic therapy on 30-day outcome in patients with intermediate risk pulmonary embolism - propensity score-adjusted analysis
Authors: Radovanovic Nebojsa , Radosavljevic-Radovanovic Mina , Marinkovic Jelena , Antonijevic Nebojsa , Dobric Milan , Mitrovic Predrag , Prodanovic Maja , Matic Dragan , Lasica Ratko , Savic Lidija
Published: October 2019

Introduction/Objective. Patients with submassive (intermediate risk) pulmonary embolism (PE) represent a very heterogeneous group, whose therapeutic strategy still questions whether some groups of patients would have net clinical benefit from fibrinolytic therapy (FT). Methods. From the institutional pulmonary embolism registry, 116 patients with submassive PE were identified, and the relation of their outcome to FT was analyzed using the propensity score (PS) adjustment. The primary endpoint was the composite of death, in-hospital cardiopulmonary deterioration, or recurrence of PE. Safety outcomes were updated TIMI non-CABG related major and minor bleeding. Results. According to Cox regression analysis, the incidence of composite endpoint was significantly lower in patients treated with FT compared to anticoagulant therapy (AT) only (PS adjusted HR 0.22; 95% CI 0.05?0.89; p = 0.039). But, when patients were stratified into four PS quartiles, only patients in the highest PS quartile that received fibrinolysis, had significantly lower composite event rate than patients treated with AT (HR 0.20; 95% CI 0.01?0.56; p = 0.016). The overall mortality of the study group was 5.2% and there was no significant difference between the treatment groups. Total bleeding was significantly more frequent in FT patients (HR 3.07; 95% CI 1.02?13.29; p = 0.047), but not the major one. Conclusion. The use of FT was associated with a better outcome compared to AT in patients with submassive PE, but the benefit was mainly driven from those with highest values of PS, i.e. with the highest baseline risk. The rate of major bleeding was not significantly increased by FT.
Relationships within the Fraud Diamond: The Decision Processes That Influence Fraudulent Intentions in Online Consumer Fraud
Authors: Harrison Andrew J. , Dilla William N. , Mennecke Brian E.
Published: October 2019

Online consumer fraud is a problem with significant consequences. While a substantial body of research examines the strategies used to defraud consumers in online environments, little is known about the decision processes that perpetrators follow before engaging in fraud. To address this issue, we develop an ethical decision-making model of online consumer fraud based on the fraud diamond. The model also includes anonymity, a key feature of online environments, which can influence sellers' ethical decision-making processes. We empirically evaluate the model first by asking participants to consider the misrepresentation of an asset's value in an online transaction, and then by having participants engage in a real-life version of that scenario. Results indicate that perceived anonymity affects the influences of capability, opportunity, and motivation on rationalization. Further, greater perceived anonymity increases the influence of rationalization on one's intent to act.
Do Voluntary Disclosures Mitigate the Cybersecurity Breach Contagion Effect?
Authors: Kelton Andrea Seaton , Pennington Robin R.
Published: October 2019

In this study, we investigate the negative impact of a cybersecurity breach on a bystander (i.e., non-breached) firm in the same industry, referred to as investment contagion effects, and whether voluntary cybersecurity disclosures mitigate these effects. Using an experiment with nonprofessional investors, we provide strong evidence of investment contagion effects. However, we also find a portion of investor participants perceive the breach as positive news for the bystander firm, a phenomenon known as competition effects. Our evidence suggests contagion effects are dominant over competition effects, and cybersecurity disclosures provided prior to the breach announcement attenuate contagion effects. Additionally, we find cybersecurity disclosures provided subsequent to the breach announcement can reduce the magnitude of investment contagion effects. Our study informs standard setters and firms as we find some evidence that voluntary disclosures are effective in lessening investment contagion effects.
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility
Authors: Tan Sih Min , Ziemann Mark , Thallas-Bonke Vicki , Snelson Matthew , Kumar Vinod , Laskowski Adrienne , Nguyen Tuong-Vi , Huynh Kevin , Clarke Michele V. , Libianto Renata , Baker Scott T. , Skene Alison , Power David A. , MacIsaac Richard J. , Henstridge Darren C. , Wetsel Rick A. , El-Osta Assam , Meikle Peter J. , Wilson Scott G. , Forbes Josephine M. , Cooper Mark E. , Ekinci Elif I. , Woodruff Trent M. , Coughlan Melinda T.
Published: October 2019

The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. We explored the role of the innate immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in clinical and experimental diabetes. Marked systemic elevation in C5a activity was demonstrated in patients with diabetes; conventional renoprotective agents did not therapeutically target this elevation. C5a and its receptor (C5aR1) were upregulated early in the disease process and prior to manifest kidney injury in several diverse rodent models of diabetes. Genetic deletion of C5aR1 in mice conferred protection against diabetes-induced renal injury. Transcriptomic profiling of kidney revealed diabetes-induced downregulation of pathways involved in mitochondrial fatty acid metabolism. Interrogation of the lipidomics signature revealed abnormal cardiolipin remodeling in diabetic kidneys, a cardinal sign of disrupted mitochondrial architecture and bioenergetics. In vivo delivery of an orally active inhibitor of C5aR1 (PMX53) reversed the phenotypic changes and normalized the renal mitochondrial fatty acid profile, cardiolipin remodeling, and citric acid cycle intermediates. In vitro exposure of human renal proximal tubular epithelial cells to C5a led to altered mitochondrial respiratory function and reactive oxygen species generation. These experiments provide evidence for a pivotal role of the C5a/C5aR1 axis in propagating renal injury in the development of DKD by disrupting mitochondrial agility, thereby establishing a new immunometabolic signaling pathway in DKD.
Cannabis Use Is Associated With Increased Risk for Diabetic Ketoacidosis in Adults With Type 1 Diabetes: Findings From the T1D Exchange Clinic Registry
Authors: Kinney Gregory L. , Akturk Halis K. , Taylor Daniel D. , Foster Nicole C. , Shah Viral N.
Published: October 2019

OBJECTIVE

We examined the frequency of diabetic ketoacidosis (DKA) in cannabis users compared with nonusers in the T1D Exchange clinic registry (T1DX).

RESEARCH DESIGN AND METHODS

The association between cannabis use by total substance score for cannabis (TSC) and DKA in the past 12 months was examined using a logistic regression model adjusted for potential confounders among adults in the T1DX.

RESULTS

Of 932 adults with type 1 diabetes, 61 had a TSC >4, which classified them as moderate cannabis users. Adjusting for sex, age at study visit, and HbA1c, cannabis use was associated with a twofold increase in risk for DKA among adults with type 1 diabetes (odds ratio 2.5 [95% CI 1.0–5.9]).

CONCLUSIONS

Cannabis use was associated with an increased risk for DKA among adults in the T1DX. Providers should inform their patients of the potential risk of DKA with cannabis use.
TOTAL QUALITY MANAJEMENT (TQM) SEBAGAI MANAJEMEN MUTU ALTERNATIF PADA PROGRAM STUDI PENDIDIKAN BAHASA ARAB
Authors: Syarifuddin Syarifuddin
Published: October 2019

Total Quality Manajement (TQM), yang pada mulanya adalah salah satu manajemen mutu yang diterapkan di perusahaan, merupakan suatu pendekatan sistematis dan hati-hati untuk mencapai tingkatan kualitas yang tepat dengan cara yang konsisten dalam memenuhi kebutuhan dan keinginan pelanggan. Program studi Pendidikan Bahasa Arab (prodi PBA) memerlukan suatu manajemen mutu pendidikan yang menjamin pelanggan atau stake holdernya ‘puas’. Tulisan ini menawarkan TQM sebagai alternatif manajemen mutu yang bisa diterapkan di prodi PBA. TQM mempunyai empat unsur pokok yang bisa ditemukan dan diterapkan juga pada prodi PBA yaitu: pelanggan, respek terhadap setiap orang, manajemen berdasarkan fakta, dan perbaikan berkesinambungan. TQM juga mempunyai dua standar mutu yang bisa diimplementasikan pada prodi PBA yaitu (1) standar produk atau jasa (quality in fact), yaitu: kesesuain dengan spesifikasi; keseuaian dengan tujuan dan manfaat; tanpa cacat (zero defects); dan selalu baik sejak awal, dan (2) standar Pelanggan (quality in perception), yaitu: kepuasan pelanggan; memenuhi kebutuhan pelanggan; dan menyenangkan pelanggan.
Visionary exploration of Chetan Bhagat's Works
Authors: John Srikanth
Published: October 2019

In his research, Mr. Mukherjee took a systematic and narrative approach. While explaining all works of Chetan Bhagat till date, he carefully selects the phrases and adjectives to throw the light on each character’s nature and behavior. Like in his words below, you would understand the characters’ nature even if you did not read the book “Five Point Someone”. “It is a fascinating book depicting the hopes and aspirations of Hari, Alok and Ryan who are typical as well as strong individuals having different aims and ambitions and at the same time they also represent the broad community of the prestigious institutes of the nation”.
The Role of Technology in Higher Education
Authors: SUBRAMANIAN Dr. A.
Published: October 2019

Present status and use for educational purposes, technology is fulfilling an ever increasing role in both the traditional education field, and in other fields which are utilizing technology for educational purposes. Within the educational field we can see technology as a means of removing barriers for students and teachers alike. First, technology can remove financial and geographical barriers through distributed learning. This allows students and teachers to experience educational opportunities that they might have otherwise never been able to encounter. Second, technology is bringing about a new focus on problem and skill based learning. Information databases are being used to assist teachers in the acquisition of new knowledge and provide professional support outside of the traditional professional development seminar. In regards to future action, we should continue to utilize the successful trends in education as a means to fulfil their developmental potential and see increased impacts on our field. In particular, we should continue the use of distance learning as a means of professional development for teachers, by providing more opportunities aimed at improving their job related performance. Distance learning for students should also be an area of focus by providing software that allows for increasing authenticity in simulations, multimedia content, and social connections. We should continue to focus on technology that allows students to interact with other students and environments located outside of their current environment, locality, and culture. Information systems are also in need of continual investment. Information systems perform two important roles for the educational system: Focus on this paper, technology has already served an important role in education in multiple fields. Specifically, technology has been of great use to the educational field in terms of its focus on improving the effectiveness and efficiency of the educational experiences of both students and teachers. Continued use and development of technology can serve to further benefit the educational field and recommendations based on the development of existing trends in education should be pursued for great gains in educational achievement..
An Exploration the Risk of Cardiovascular Disease in HIV-Positive Persons in Indonesia using Heart Rate Variability
Authors: Lindayani Linlin , Darmawati Irma , Purnama Heni , Pujowati Pujowati , Taryudi Taryudi
Published: October 2019

Cardiovascular disease is the highest cause of death in HIV patients compared to the general population. The number of HIV patients suffering from cardiovascular disease is almost twice as high as patients who are not HIV-positive.The purpose of this study was to identify the risk of cardivascular disease in patients with HIV using ECG short term. This study was used a descriptive comparative to patients with HIV and healthy people as controls in West Java. The inclusion criteria are patients with HIV over the age of 30 years. The exclusion criteria were people with HIV diagnosed with heart disease or being treated for the heart disease. While the inclusion criteria for healthy people as controls are over 30 years of age, do not suffer from cardivascular disease or under treatment of cardiovascular disease. The measurement of heart rate variability is carried out in a supine position in a quiet temperature-controlled room (25-270 C), a 5-minute electrocardiograph (ECG) is recorded using lead II. Differences of heart rate variability indicator were measure using man-whitney test. A total of 20 patients with HIV and 20 healthy people recruited using convinience sampling. The majority of people with HIV were male and aged range between 27 to 51 years old. The results of heart rate variability based on time domain analysis showed that the means normal to normal (NN) was significantly lower in HIV patients compared to controls (978 vs ?? vs 902 ms; p<0.05). No differences were found between groups regarding Standard deviation of NN (SDNN), Square root of the mean squared difference of successive NN-intervals (RMSSD) and Percent of differences between adjacent NN intervals greater than 50 ms (pNN50). This study presence of autonomic dysfunction as showed in heart rate variability indicator in a group of HIV compared to the healthy group. Eearly identification of the risk of CVD is important and may inform the implementation of preventive measure by identification of high-risk people who may be candidate for intervention.
Tera Gymnastic Effective for Patient with Hypertension
Authors: Platini Hesti , Pebrianti Sandra , Maulana Indra
Published: October 2019

Hypertension is a cardiovascular disease globally. Hypertension is remains silent killer, the clinical strategy to focusing on new and improved treatments is exercise. Tera  gymnastics is a physical and mental exercise, combining the movement of body parts with breathing techniques and rhythms through the concentration of thought that is carried out regularly, harmoniously, correctly and continuously, Physical activity can reduce high blood pressure. Some study showed Regular physical activity is an effective intervention with respect to these factor, decreasing mortality rate for cardiovascular disease and all cause of disease in hypertensive patient. Gymnastic Tera exercise can help to control metabolic variable related to hypertension. The study was use quasy experimental design with one group pretest-posttest. The study was conducted in Puskesmas Pasundan Garut. Sampling in this study is subjects  that is criteria patients has hipertension with 8 weeks treatment so will take methode of  concecutive sampling with 15 respondents for intervention group and 15 for control group.  The sample were age 30-55 years. The Intervention was gymnastic tera exercise. The Blood pressure function was evaluated before and after the training period. The data were analyzed by using t-test paired. The result showed a significant difference before and after tera gymnastic exercise in patient with hypertension I (p=000.0). Result of systolic blood presure when in mean SD pretest is 146.00 higher than post test is 136.00 in intervention group. The tera gymnastic exercise conditioning program achieved effect in this population. The reduction of blood pressure after exercise is of great clinical relevance.  The increased riskof physical inactivity in controlling hypertension in our study suggest that general practitioners must be in the habit of prescribing practice of physical exercise. Physical activity has been shown to have beneficial effect on blood pressure. patients are followed up regularly to confirm that they are adhering to the management plan and the blood pressure targets.
New Media 3.0: Merancang Model Pemberdayaan Komunikasi Politik yang Interaktif
Authors: Sujoko Anang
Published: October 2019

The use of new media in Indonesia significanty grows, especially among the youth generation. Unfortunately, it does not happen in the youth community organization. This study aims to determine the factors that become obstacles for youth community organizations in managing new media for the benefit of the organization. This research is a mixed method by using survey data collection techniques to identify the level of use of new media in each organization and focus group discussion (FGD) to obtain more in-depth data about the problems that become obstacles in its management. This study succeeded in digging data from 15 youth community organizations in the City of Kediri. This research succeeded in mapping the problems experienced by CSOs in utilizing the internet and its interactive platforms. Based on a survey conducted on 15 CSOs, it was found that the main problem faced was the unavailability of qualified human resources in CSOs that were specifically tasked with managing CSO social media accounts. This is also due to the low awareness of CSOs about the potential of the internet and new media 3.0 to treat their political audience. Furthermore, another obstacle faced is the difficulty in producing content. Based on the focus group discussion conducted to follow up on the results, the researcher concluded the two conditions above because CSOs do not have sufficient awareness and knowledge of the potential of the use of the internet and all its interactive platforms for political communication. The conclusion of this study is that the management of new media for organizations has not been taken seriously because of the low level of awareness of the importance of new media for organizational development. However, the design of the digital storytelling concept in order to create a sanse of belongings for the political audience of each community organization is seen as an alternative management solution after the appointment of manager responsibility.
Combined Small‐Sided Game and High‐Intensity Interval Training in Soccer Players: The Effect of Exercise Order
Authors: Rabbani Alireza , Clemente Filipe Manuel , Kargarfard Mehdi , Jahangiri Saeid
Published: October 2019

The aim of the present study was to compare combined small‐sided game (SSG) and high‐intensity interval training (HIT) with different order. Twenty‐one semi‐professional soccer players were divided into two groups: SSG+HIT (n = 10) and HIT+SSG (n = 11), and underwent similar four‐week training programs. Players completed the 30‐15 Intermittent Fitness Test (30‐15IFT) before and after the experiment; maximum speed (VIFT) was recorded. During the experiment, seven sessions of SSG (3 vs 3) and HIT (15ʺ‐15ʺ with 95‐100% VIFT) were implemented. Weekly accumulated training loads for both groups during the experiment were similar. Moderate improvements in VIFT were observed in both SSG+HIT (+6.2%, 90% confidence limits, [CL] 4.6; 7.7 and Effect Size, [ES] +0.96) and HIT+SSG (+6.9%, 90% CL 4.6; 9.3 and ES +0.97) groups. Between‐group difference in changes of VIFT was trivial (+0.7%, 90% CL ‐1.8; 3.3 and ES +0.11). Combining SSG and HIT in different order elicited the same enhancement in high‐intensity intermittent performance in soccer players.
Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes: A Pilot Study
Authors: Hafedh Hanen , Slimani Maamer , Miarka Bianca , Bettayeb Ramzi , Bragazzi Nicola Luigi
Published: October 2019

This study aimed to investigate the effects of beta2‐agonist terbutaline sulfate (TER) at a supra‐therapeutic dose (8 mg) on aerobic exercise performance. Twelve (6 females and 6 males) amateur athletes familiarized with all experimental procedures had their anthropometric data obtained on day 1. On days 2 and 3 either 8 mg of TER or a placebo (PLA) was administered orally (double‐blind manner) to participants who had rested for 3 h prior to aerobic exercise performance 20 m multistage fitness test (MSFT)]. This test was used to predict maximal oxygen uptake (VO2max) and velocity at which VO2max occurs (vVO2max). The Borg rating of perceived exertion (RPE), cardiovascular variables [heart rate (HR) and blood pressure (BP)] and blood glucose concentration [BGC] were obtained 15 min pre‐ and immediately post‐MSFT. Significant mean group differences were reported between PLA and TER groups (p < 0.05), respectively, in the RPE (15.6 ± 1.2 vs. 17.3 ± 1.5 a.u.), maximum heart rate (HRmax: 191.2 ± 7.1 vs. 197.2 ± 8.6 bpm) and BGC (118.4 ± 18.3 vs. 141.2 ± 15.8 mg/dL) post‐MSFT. The main effect of gender (male vs. female) in TER and PLA groups (p< 0.05) was observed, with higher estimated VO2max, vVO2max, HRmax and a lower mean HR pre‐test in male than female athletes. For these reasons, the inclusion of TER in the Prohibited List should be re‐discussed because of the lack of ergogenic effects.
Differences in Mechanical Midsole Characteristics of Running Shoes Do Not Influence Physiological Variables in Aerobic and Anaerobic Running
Authors: Mitschke Christian , Karger Katrin , Milani Thomas L.
Published: October 2019

The purpose of this study was to determine the influence of footwear stiffness and energy loss on oxygen uptake and heart rate in athletes running under aerobic and anaerobic conditions. Four footwear conditions with identical outsoles, insoles, upper materials, but different mechanical properties regarding polyurethane midsole materials were investigated. Respective midsole material characteristics were selected to represent a wide range of running shoes. The test procedure for eighteen well‐trained male runners was divided into three treadmill testing sessions: an incremental ramp protocol to estimate the individual ventilatory threshold (day 1), a test with 6‐minute stages in each shoe at 70% (aerobic, day 2) and 102% (anaerobic, day 3) of the participant’s ventilatory threshold. For oxygen uptake and the heart rate, no significant differences between footwear conditions were found for either running condition. Furthermore, no significant relationships between physiological variables and mechanical midsole characteristics were found. The wide range of significant stiffness differences in the rearfoot (52.7 N/mm) and forefoot areas (50.7 N/mm), as well as significant differences of the shoe midsole material energy loss in the rearfoot (18.8%) and forefoot areas (10.7%) were too low to influence physiological variables significantly when running below and slightly above the ventilatory threshold. It seems that shoe mass and shoe comfort can influence physiological variables more than the mechanical midsole characteristics of stiffness and energy loss. These results may have practical implications for shoe manufacturers, coaches, and athletes, alike.
Consistency or contradiction? Mobility- Related Attitudes and Travel Mode Use of the Young ‘New Generation’
Authors: Konrad Kathrin , Groth Sören
Published: October 2019

In this paper, we examine the role of mobility-related attitudes in the travel mode use of young people, the extent to which young adults and teenagers behave consistently in relation to their attitudes, and the conditions on which the consistency of attitudes and behaviour depends. We thus continue the current discussion about the loss of importance of the car for young people in which various socio-demographic trends, but also changed attitudes, are used as explanatory factors, especially on a hypothetical level. Our contribution closes a research gap in that so far neither the relationship between attitudes and behaviour among young people has been empirically investigated nor has this relationship been empirically placed in a context of spatial, economic and socio-demographic conditions. We address this by means of differentiated correlation analyses and the calculation of correlation differences on the basis of a nationwide German survey of young people from 2013. This enables us to demonstrate that young people basically behave consistently in line with their attitudes. However, there are significant differences which confirm that certain spatial, economic and socio-demographic conditions are essential for the implementation of attitudes into corresponding travel mode use.
James Madison et Le Fédéraliste : optimisme, réalisme et modernité
Authors: Le Moine François
Published: October 2019

Après la victoire sur les troupes de Cornwallis et la reconnaissance de l‘indépendance par le traité de Paris en 1783, une certaine désorganisation règne dans les colonies américaines. La guerre avait été un outil puissant de cohésion. La Déclaration d‘Indépendance (1776) avait donné un sens à la lutte et les treize Articles de Confédération et d‘union perpétuelle (1777) avaient créé une assemblée fédérale qui devait décider de la politique étrangère et régler d‘éventuels contentieux entre les colonies. Mais une fois la victoire acquise, ce mécanisme ne suffit plus : « La Confédération était en effet constituée uniquement par un Congrès continental hypertrophié [...]