bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Blockchain in the Saffron Industry
Authors: Zugaro Riccardo , De Giovanni Pietro
Published: December 2021

In the era of tech-driven globalization, supply chains are becoming increasingly complex, with an increasing number of stakeholders spread across continents. A complex supply chain requires complex management systems. Supply chain management digitalization and information technology have advanced simultaneously in time, but a more technological and connected society calls for more information, uncovering the limits of supply chain management tools available today, which, while providing efficiency, automation, and organizational capabilities, are quite scarce in providing transparency. Consumer awareness on sensible issues such as climate change, human rights, or counterfeiting is increasing.
Study and Application of Machine Learning Methods in Modern Additive Manufacturing Processes
Authors: Barua Ranjit , Datta Sudipto , Datta Pallab , Roychowdhury Amit
Published: December 2021

Additive manufacturing (AM) make simpler the manufacturing of difficult geometric structures. Its possibility has quickly prolonged from the manufacture of pre-fabrication conception replicas to the making of finish practice portions driving the essential for superior part feature guarantee in the additively fabricated products. Machine learning (ML) is one of the encouraging methods that can be practiced to succeed in this aim. A modern study in this arena contains the procedure of managed and unconfirmed ML algorithms for excellent control and forecast of mechanical characteristics of AM products. This chapter describes the development of applying machine learning (ML) to numerous aspects of the additive manufacturing whole chain, counting model design, and quality evaluation. Present challenges in applying machine learning (ML) to additive manufacturing and possible solutions for these problems are then defined. Upcoming trends are planned in order to deliver a general discussion of this additive manufacturing area.
Gamification Applied to Autism Spectrum Disorder
Authors: Simões-Silva Vítor , Marques António , Pinho Catarina , Pereira Diana Gonçalves , Oliveira Joana Ferreira , Barros Maria Luísa
Published: December 2021

Gamification is a recent technique in software development that allows the application of game principles to non-game contexts and environments. In an increasingly technological world, gamification has now higher popularity, and it is currently used in several technologies. One of the health conditions where gamification can bring great benefits is in autism spectrum disorder (ASD), which is a persistent neurodevelopmental disorder that can be characterized briefly by deficits in verbal and non-verbal communication, difficulties in interaction, and manifestation of stereotyped movements or interests. In the case of ASD, the programs, software, or the mobile applications should focus on the development of intrapersonal (such as motivation) and interpersonal (social skills) skills. Therefore, gamification can be useful in cases of ASD, but it is necessary to increase the analysis of the potentialities and needs for improvement of technologies and applications available on the market.
Usability and Applications of Virtual and Augmented Reality in Older Adults
Authors: Cavalcante Danisio Calixto , da Fonseca Gislaine Carvalho , Joaquim Stephanie Bittencourt , Simões Suzana Aristeu
Published: December 2021

Virtual reality (VR) and augmented reality (AR) have been explored to be an effective alternative to integrating mental health intervention proposals, particularly in eldercare. The objective is to map the usability and applications of VR and AR technologies in interventions for the elderly population. The main areas of interventions in AR and VR applied to the elderly are stimulation and cognitive rehabilitation, physical rehabilitation, treatment of mental diseases, and promotion of quality of life. Despite the need for further studies, VR and AR have strong adherence among the elderly and demonstrate promising potential in interventions that seek to promote mental health and improve the quality of life.
Using Simulation to Improve Adherence to Get With the Guidelines Time to First Shock
Authors: Paddock Andrea
Published: December 2021

Background

Evidence demonstrates that shocking patients in ventricular fibrillation or pulseless ventricular tachycardia in 2 minutes or less leads to improved outcomes. At our facility in Orlando, Florida, 4 of 7 time to first shock fallouts occurred in the intensive care unit. No standardization for conducting code situations existed in the intensive care unit.

Objective

To develop nurse simulation education and training to standardize intensive care unit code processes and improve compliance with timely defibrillation.

Methods

The sample consisted of intensive care unit nurses. Interventions included online education, simulation, and a postintervention survey. Analysis was conducted using the Get With the Guidelines program as well as descriptive statistics.

Interventions

Online education assigned to all intensive care unit nurses included electrocardiogram recognition and code documentation. Nurses and physicians collaborated to develop a diagram to identify roles needed for successful conduct of a code situation. A code simulation video was created, reflecting these roles, and embedded in the online education. The education was graded and remediated one-on-one with nurses. Intensive care unit nurses completed structured code simulations, allowing them to practice serving as the leader. Three months after the intervention, a survey was distributed to nurses.

Results

The time to first shock fallouts in the intensive care unit decreased by 100%, and the facility’s fallouts decreased by 71%. The facility’s adherence to the time to first shock metric increased from 42% to 83%. In a postintervention survey, 89% of nurses reported perceived improvement in knowledge, team leadership and communication, and confidence associated with code events.

Conclusions

Online education and code simulation positively affected time to first shock in code situations and empowered nurses to confidently function in these situations.
Perspectives of Medical Treatment for Overactive Bladder
Authors: Lin Chu-Tung , Chiang Bing-Juin , Liao Chun-Hou
Published: December 2021

Overactive bladder (OAB) syndrome is a clinical symptom diagnosis. Treatment strategies are aimed at relieving symptoms. Because antimuscarinic drugs are applied for OAB, several targets of treatment about OAB had been found and newer treatments were also discovered. Besides, further studies about the potential advantages of combination therapy are proved to have increased efficacy and acceptable tolerability. Our study aims to update clinicians managing an OAB with an overview of the existing and newer medical therapies for OAB, including pharmacology, efficacy, side effects, and impact on the patient's quality of life. We review the most frequently used pharmacological therapies and new agents aimed at treating OAB. PubMed and Medline were explored for randomized controlled drug trials in adults with OAB, meta-analyses of medical therapy for OAB, and individual drug names, including the keywords efficacy, tolerability, quality of life, and compliance. In conclusion, newer antimuscarinic drugs focus on more selective muscarinic receptors with less side effects. Some β3-adrenoceptor (β-AR) agonists had also been approved in Japan, and Phase III study is ongoing in the USA. In addition to antimuscarinic drugs and β-AR agonists, several newer treatments, such as intravesical botulinum toxin injection and phosphodiesterase-5 inhibitors, were proved to improve OAB symptoms. The new targets of treatment should be the focus of future studies.
Therapeutic Efficacy and Quality of Life Improvement in Women with Detrusor Underactivity Following Transurethral Incision of the Bladder Neck
Authors: Lee Yu-Khun , Kuo Hann-Chorng
Published: December 2021

Aims:

To investigate the effects of transurethral incision of the bladder neck (TUI-BN) on long-term outcomes and quality of life (QoL) improvements in women with detrusor underactivity (DU) refractory to standard medical treatment.

Materials and Methods:

Data were retrieved for female patients with treatment-refractory DU who underwent TUI-BN between 2007 and 2018. Urodynamic parameters were measured at baseline and follow-up and were analyzed for surgical outcome. Patients who were capable of spontaneously voiding with a voiding efficiency (VE) of ≥50% with or without the aid of abdominal pressure were considered to have achieved satisfactory outcomes. Changes in self-reported QoL were measured based on the International Prostate Symptom Score QoL (IPSS-QoL), and treatment improvements were measured based on the global response assessment (GRA) index. Moreover, the voiding statuses of patients before and after TUI-BN were compared.

Results:

Overall, 82 women, with a mean age of 60.8 ± 17.9 years (range 12–102), were included. Most patients experienced chronic urinary retention or large postvoid residual (PVR) urine. Median follow-up period was 5 years (range 1–12). Following TUI-BN, 40 (48.8%) patients achieved satisfactory outcomes, with a mean GRA of 1.4 ± 0.93. Mean maximum flow rate, voided volume, PVR volume, VE, and IPSS-QoL were all significantly improved. Among all patients, 50 (61%) were subsequently able to spontaneously void with or without the aid of abdominal pressure without the need for catheterization. Indwelling catheters were required in 19 (23.2%) patients at baseline and in 5 (6.1%) following TUI-BN (P < 0.01). Moreover, 5 (6.1%) patients developed stress urinary incontinence and 2 (2.4%) experienced vesicovaginal fistulae following TUI-BN procedures, all of whom recovered satisfactorily after treatment.

Conclusions:

TUI-BN is an effective procedure for reducing the bladder outlet resistance and improving VE and QoL. Moreover, the procedure is durable with an acceptable incidence of complications.
Pelvic Lymph Node Dissection Using Indocyanine Green Fluorescence Lymphangiography in Robotic Assisted Radical Prostatectomy for Non-Lymph Node or Distant Metastasis Prostate Cancer Patients
Authors: Chuang Yu-Feng , Ou Yen-Chuan , Lin Yi-Sheng , Huang Li-Hua , Weng Wei-Chun , Chang Yu-Kang , Chen Hung-Lin , Hsu Chao-Yu , Tung Min-Che , Lu Chin-Heng
Published: December 2021

Purpose:

The utility of indocyanine green dye (ICG) has evolved significantly to the robotic operations including Robotic Assisted Radical Prostatectomy (RARP). The technology can help the identification of sentinel lymphatic drainage in lymphadenectomy for the majority of prostate cancer (PCa) patients. We describe the potential indications of ICG for lymphadenectomy assistant in PCa patients without lymph node or distant metastasis.

Materials and Methods:

We prospectively analyzed PCa patients without lymph node or distant metastasis with clinical pathological stage T1c to T3a received RARP from November 2019 to May 2020. The clinical data and pathological data, including Gleason score, tumor volume, pathological stage, and surgical findings, were described. All lymph nodes were divided into ICG positive or negative. All patients were divided into low, moderate, and high risk according to the European Association of Urology PCa risk stratification.

Results:

Cystoscope-guided intraprostatic injection was performed successively in 34 localized PCa patients in this study. The mean age was 66.1 ± 7.8 years old. The patients' number of high, moderate, and low risk was 18, 10, 6. A total of 447 lymph nodes were identified. Two hundred and sixty-two lymph nodes were ICG positive and 181 lymph nodes were ICG negative. ICG positive rate higher in high risk patients 158/259 (61.0%) compare to intermediate/low risk patients 104/188 (55.3%). There was no statistic significant result, but lymph node could be identified in all ICG-positive tissues. There were 12 patients revealed higher Gleason grade group after RARP and two patients revealed lower Gleason grade group after RARP. There were 18 patients showed upgrade stage after RARP and 4 patients showed down stage after RARP.

Conclusion:

Cystoscope-guided intraprostatic ICG injection with fluorescence lymphangiography can help identify pelvic lymph nodes in RARP for PCa patients without lymph node or distant metastasis.
STRATEGI PENGEMBANGAN USAHA TOKO SEMBAKO INJEK BALANJA MENGGUNAKAN ASSET BASED COMMUNITY DEVELOPMENT
Authors: Pemi  , Beni Sabinus
Published: December 2021

Perdagangan merupakan akar pokok pembangunan nasional dan pembangunan daerah. Yang bertujuan untuk mewujudkan masyarakat yang maju dan mandiri serta sejahtera lahir dan batin. Di daerah perbatasan saat ini tentunya sangat dibutuhkan kebutuhan sembako, karena kebutuhan bahan sembako yang masih terbatas, sehingga sebagian pasokan sembako dan kebutuhan lainnya masih didatangkan dari negara lain tentunya. Penelitian ini bertujuan untuk mengangkat permasalahan mengenai “ Bagaimana desain strategi pengembangan berbasis asset yang dapat dilakukan oleh Toko Injek Balanja dan Bagaimana Implementasi strategi pengembangan berbasis asset yang dilakukan oleh Toko Injek Balanja”, untuk dapat menarik minat konsumen, strategi pembangunan Usaha Toko Sembako Injek Balanja yang berada diperbatasan menggunakan Asset Based Community Development. Penelitian ini menggunakan metode jenis penelitian kualitatif. Penelitian ini merupakan penelitian yang menghasilkan kata-kata secara tertulis atau lisan dari objek yang diamati dan hasil dari wawancara, Penelitian ini berlokasi di dusun Tanjung, Kecamatan Sajingan Besar, Kabupaten Sambas. Adapun teknik pengumpulan data yang dilakukan adalah observasi, wawancara, kuesioner, dan dokumentasi. Dalam penelitian ini akan menggunakan prosedur yang dapat menghasilkan data yang berupa deskriptif dari ucapan, tulisan, perilaku, objek itu sendiri. usaha sembako Injek Balanja merupakan usaha yang akan menyediakan segala kebutuhan bahan-bahan sembako yang dimana toko sembako Injek balanja akan memenuhi kebutuhan yang dicari masyarakat. dimana Toko Sembako Injek balanja berkesempatan untuk menyediakan segala kebutuhan sembako agar orang-orang di sekitar tidak lagi mencari di kejauhan kebutuhan sembako ini. Sembako akrab di telinga  masyarakat Indonesia. Tentu saja karena hal tersebut sangat dekat dengan kebutuhan manusia. Secara luas sembako ini kebutuhan pokok yang selalu dibutuhkan manusia dalam kegiatan pemenuhan kebutuhannya atas pangan dimana bahan-bahan sembako yang pastinya dicari masyarakat hampir setiap harinya untuk pemenuhan kebutuhan rumah tangga. Perkembangan usaha sembako yang berbasis asset. Guna untuk memanfaatkan asset-asset yang telah ada. untuk dijadikan peluang usaha dengan sudah adanya memiliki fasilitas-fasilitas yang mendukung untuk mempermudah melakukan suatu kegiatan usaha. Usaha yang berbasis asset agar dimanfaatkan dengan baik serta lebih meningkat dan baik lagi.
Giro político y democracia en Sudamérica y Ecuador
Authors: Pachano Simón
Published: December 2021

En esta obra Simón Pachano desarrolla una reflexión comparada, original y en profundidad sobre las conexiones y el mutuo condicionamiento entre tres fenómenos clave desde los inicios del siglo XXI en Sudamérica. Toma al Ecuador como país de referencia en el tercer capítulo. Para el autor, el análisis comparado del giro a la izquierda –y su definición–, el debate sobre los regímenes híbridos y el retroceso de la calidad democrática constituyen la ocasión no solamente para llenar un vacío en la literatura comparada internacional, sino también para analizar causas y explicaciones que ilustran la complejidad de los procesos estudiados.
ANALYSIS OF RASA SINDOORA BY NAMBURI PHASED SPOT TEST (NPST)
Authors: Arjaria Anamika , Upadhyay Shankar Dayal , Malviya Vidhiya
Published: December 2021

Introduction: Rasa Sindoora (Red Sulfide of Mercury) is a herbomineral preparation and a well-known Kupipakwa Rasayana kalpana. An equal ratio of Shodhita Parad (Purified Mercury) and Shodhita Gandhaka (Purified Sulphur) was used to prepare Rasa Sindoora. The form of preparation which was considered by Rasa Acharya to know the effect of minimizes dose for therapeutic purpose. To analyze the medicine the best way is to standardize it and after that analyse with standard and sophisticated instrumental techniques. Aims: To ensure and assess the quality of Rasa Sindoora through Namburi Phased Spot Test (NPST) analysis. Material and Method: To assess the quality with the standard monograph of NPST - 3 Papers of Potassium Iodide, Potassium Bromide and Haridra were prepared and identify the changes on all three papers by the action of prepared solution of Rasa Sindoora in freshly prepared aqua regia. Result: All three papers of Potassium Iodide, Potassium Bromide and Haridra showed a positive result in all three phases on comparing with the standard of NPST monograph.
Keywords: Rasa Sindoora, KupipakwaRasayana, Namburi Phased Spot Test (NPST).
A PHARMACEUTICAL ANALYTICAL STUDY OF MURCHITA GO-GHRITAM & CHAGALADYA GHRITAM
Authors: Kannalli Prabhakar H. , Gowda Shankara , M Usha. , Chavan Ravi R
Published: December 2021

Ghee known as Ghritam, sarpish & Ajya, was used in ancient India as early as 1500 B.C. Rigveda, the oldest collection of Hindu hymns, contains numerous references to ghee, showing its importance in the Indian diet. The health benefits from ghee can be fundamentally categorized as those that are obtained from consuming ghee as food and those are obtained by using ghee as a medicine. Clarified milk fat or butterfat is known as ghrita. It is prepared by heating butter or cream to just over 100°C to remove water content. Goghrita is the best choice for food and medicinal purposes. So, in Ayurvedic classics and tradition, if not specified, the word ghrita always applies to goghrta. Chagaladya ghrita is one such classical, potent, unexplored, herbal preparation having properties of Jwara-prashamana (Antipyretic action), Dhatu-vriddhikara (Nourishes the Body tissues), improves mainly Mamsa dhatu, where dhatu kshaya is noticed in Rajyakshama Rogi by consuming of this Aja-Mamsa can restore the Mamsa dhatu kshaya (Mamsena Mamsa vruddhihi), also Increases body weight (Brimhanakaraka), Ojoskara (Immune- booster) indicated in the management of Rajyakshama presenting with predominant of Shwasa and Kasa. It contains mainly Chagamamsa (goat’s meat), Ashwagandha, Vasapanchanga, Chagadugdha and Goghrita and other Prakshepaka dravyas. Ghrita is one among the best Ajasrika Rasayanas. and is supreme in Snehana Dravyas. By its Yogavahitva, as per its ingredients, the medicated Ghrita will be attaining properties of the ingredients without forfeiting its properties.
Keywords: Murchita Go-ghrita, Chagaladya Ghrita, Snehapaka, TLC
MEDICAL MANAGEMENT OF TINEA INFECTION THROUGH SHODHANA AND SHAMANA – A CASE SERIES
Authors: Bhat Asha A , A S Prashanth
Published: December 2021

Skin is one of the most beautiful organs God has ever blessed to anyone. Everyone craves for beautiful skin and makes all possible efforts to make it glow. To achieve this, they are engaged in continuous use of creams, moist- urizers and other cosmetic articles which lead to immediate or long-term skin issues. Itching being the predomi- nant symptom of these cosmetic issues make people highly embarrassed in society. In Ayurveda, almost all skin conditions are explained under one umbrella called Kushta. It is broadly classified into Mahakushta and Kshudra- kushta1. Dadru Kushta one among the Kshudra Kushta is the most common skin condition accounts for 20% in all consultation in general practice2. North Karnataka is well known for its hot and humid conditions making its population at risk of many Tinea infections. Kandu, Raga and Atasi Pushpa Sankashavat Mandala are the cardi- nal features of Dadru3. In the present case study, 40 patients of Dadru Kushta were taken according to inclusion criteria. The combined effect of both Shodhana and Shamana was assessed.
Keywords: Dadru Kushta, Aupasargika, Anushangi, Wilcoxon Rank Sum Test
CYCLOOXYGENASE-2 AS „IN SILICO“ TARGET OF PHENOLIC HYDRAZONE- TYPE DERIVATIVES
Authors:   University of Kragujevac, Faculty of Science, Branković Jovica , Milovanović Vesna , Petrović Vladimir P.
Published: December 2021

In the present work, a series of phenolic hydrazone analogs were investigated in silico for their potential inhibitory activity toward COX-2. These examinations were based on the capability of hydrazone-based compounds to interact with numerous enzymes, as well as on their versatile biological features and therapeutical applications. COX-2 was selected due to its involvement in the inflammation and carcinogenesis processes. Regarding this, COX-2 represents a valid target for the development of compounds that could block the formation of harmful inflammation mediators.
STUDIES OF SUBSTITUTION REACTIONS WITH IMPORTANT BIOMOLECULES AND ANTIMICROBIAL ACTIVITY OF NOVEL ZN(II)-L-CU(II) COMPLEXES
Authors:   Institute for Information Technologies, University of Kragujevac, Šmit Biljana , Halilagić Asija , Selimović Enisa , Katanić Stanković Jelena , Srećković Nikola , Soldatović Tanja
Published: December 2021

New dinuclear Zn(II)-L-Cu(II) complexes with different bridging ligands were synthesized. Interactions of these complexes with biologically important nucleophiles, 5′-GMP, 5′-IMP and GSH, were investigated by Uv-Vis spectrofotometric method. The distances between the metal ions lead to less reactivity of both centers due to reduced electronic communication between them and an increasing of electron density on the metal centers itself. Both complexes showed moderate antimicrobial activity against most of the tested bacterial and fungal strains.
CHEMICO-BIOLOGICAL INTERACTION OF SELECTED TETRAHYDROPYRIMIDINES
Authors:   University of Kragujevac, Institute for Information Technologies, Milović Emilija , Janković Nenad , Petronijević Jelena , Joksimović Nenad
Published: December 2021

Tetrahydropyrimidines (THPMs) attracted attention as a very important class of aza heterocycles with broad pharmacological activities during the past years. In many studies have been proven that THPMs have anticancer, anti-inflammatory, antimicrobial, antioxidant, antifungal, anti-HIV activity. Bearing in mind our interest in medicinal and Biginelli chemistry, we investigated interaction with important biomacromolecules (DNA, BSA) and our earlier synthetized THPMs derivatives with proven very good cytotoxic activity.[1] Investigation of affinity of compounds A and B (Figure 1) to bind to bovine serum albumin (BSA) is based on the fact that the efficiency of drugs depends on their ability to bind for carrier protein. Binding properties were investigated by using the fluorescence emission titration of BSA with A and B. The obtained values of Ka, which are in optimum range which is considered to be 106-107M-1 indicate that both compounds have great ability to bind to BSA. In addition, Ka values for A-BSA and B-BSAshow that both compounds are suitable for drug-cell
Journal of Awareness-Based Systems Change
Authors: Koenig Oliver , Pomeroy Eva , Seneque Megan , Scharmer Otto
Published: December 2021

The editorial of this second issue of the Journal of Awareness-Based Systems Change is entitled "Moving from Transactional to Relational," which we read as one of the central themes running through all of the contributions in this issue. In amplifying the voices of the authors, we contend that we have been confined and restrained by western and hegemonic notions of rationalism, reductionism, empiricism, mechanism, dualism, and causality for too long. Speaking from a relational body of knowing the various contributions assembled here represent attempts to reevaluate the ontological and epistemological positions and foundations that make up the fabric of social institutions and systems. They also suggest ways forward that hold the potential to tap into and activate the transformative potential that lies within people and systems.
Reversing The “Eclipse of Relationality”
Authors: Westoby Peter
Published: December 2021

The Jewish philosopher Martin Buber talked about, living under the shadow of Auschwitz, that humanity lived with the ‘eclipse of God’. I now wonder if we have moved beyond this ‘eclipse of God’ to a time of the ‘eclipse of relationality’.
This article argues that the eclipse of relationality is enabled through a predominant worldview in which the world is understood as mechanical and dead – observed and experienced in increasingly abstract form. In this way of being, the world and the ‘other’, cannot be loved.
In light of this eclipse, this article offers two pathways back to life, particularly for practitioners concerned with healing culture. The first is ontological – a new way of being that is experienced through a living polarity between the ideas enfolded within Jung’s theory of individuation and Buber’s dialogical theorising. The second is phenomenological – a new kind of social and ecological practice linked to a perceptivity of living process, traced from Carl Jung and James Hillman, to Mary Watkins, Henri Bortoft and Allan Kaplan. The key wisdom from this article, from travelling down these two pathways - the key theorising of a way forward for cultural healers - is that people increasingly spend so much of their life separated, a-part, lacking intimacy with another, or with the world, or the manifestations of the world that are all around them, and within them. Something is then missing – call it connection, which ensouls the world – the aliveness that invites an anticipatory and participatory relationship with the world, and importantly, a world experienced as both profound Otherness, as well as deeply Oneness. The consequences for people and the world are profound – for the experience of alienation enables abstractions to flourish, exclusions to expand, and rushed interventions to proliferate – the ‘eclipse of relationality’ beckons.
Comprehensive Assessment of The Regional Potential Investment of The Republic of Uzbekistan
Authors:   PhD, Tashkent State University of Economics, Abdullaevich Otajanov Umid
Published: December 2021

The article describes the views of scientists and the authour's approach regarding role of regions' potential socio economic in country's development and investment climate in the regions in attracting investment. In addition to the traditional method of assessing the investment climate, the author initially conducted a descriptive analysis, which in turn allows for complete information and clear conclusions on the distribution of investments in the regions. Also, as an author's approach, a methodology for assessing the investment climate in the regions on the basis of a comprehensive assessment is presented, which is assessed taking into account the specific features and capabilities of the regions of the Republic of Uzbekistan.
Over coding In Disciplines and Fields (After Deleuze) a Call for ‘Dynamic Genesis’ In Tourism Studies and Related Domains
Authors:   Independent Scholar: England & Australia, Hollinshead Keith
Published: December 2021

This manuscript applies a cross discilinary cum post disciplinary approach to scrutinising some of the metaphysical insights of French philosopher Deleuze on knowledge-production in the arts, film, literature, and science to like matters of authorial thinking within Tourism Studies. It seeks to translate his expansive thoughtlines on non-representational geophilosophy to the worldmaking agency of Tourism Studies (and related fields) not regarding what tourism is but what it does, notably in terms of how it generally works for institutions and interest groups, and how it specifically effects travellers and host populations, often giving them heavily-striated (i.e., densely-overcoded) visions of peoples/places/pasts/presents. The paper highlights many of the paradoxical dynamic dimensions ingrained within beyond-the-discipline Deleuzian thought, focusing upon his role as an ‘outsider philosopher’ who unsettles commonplace visions of being and identity (within disciplines and domains of 'knowledge') by encouraging both individuals and en groupe populations towards fresh stranger-to-oneself yet creative lines of flight depersonalised understandings. It thereby suggests that the quasi-virtual world of Deleuzian conceptuality (viz.: his paradoxical insights into virtual realms [which are conceivably real without being 'actual' and ideal without being 'abstract']) have much oxygenating relevance to ‘the creative encounter’ possibilities of travel and tourism. The paper thereby has tall relevance for those in other fields who feel distinctly constrained by the dogmatisms of their supposedly parent discipline or domain.
DE FRENTE AL XIX CONGRESO ARGENTINO DE DIABETES
Authors: Arias Pablo
Published: December 2021

Como suele ocurrir en todas las familias como parte de nuestro crecimiento como individuos, tuve una vez una seria discusión con mis padres en relación a la especialidad que había decidido elegir. Corría el fin de la vapuleada década de los años 1970 y, con el título fresquito, todavía crujiente bajo el brazo, les hice saber que era mi intención dedicarme a la atención de los pacientes con diabetes, y hacer de esta enfermedad mi campo de investigación. Guiados obviamente por los sentimientos (ambos eran primero progenitores y luego profesionales de la salud), me dijeron, con cara de extrema preocupación: “¡Cómo vas a especializarte en una enfermedad solamente, no te das cuenta que si se descubre la cura de la diabetes te vas a quedar sin trabajo!” Como todos sabemos, lamentablemente este temor dista hoy de ser una realidad y, peor aún, la diabetes mellitus constituye en la actualidad una fuente de preocupación y sufrimiento para una de cada diez personas adultas en nuestro país, y una pesadilla para los sistemas de salud por las dificultades y costos inherentes a la atención de los casi 400 millones de individuos que la padecen a nivel mundial, y por los esfuerzos necesarios para evitar que un número similar de sujetos en riesgo la desarrolle en un futuro no lejano.
Conferencias y Simposios
Authors: De Diabetes Sociedad Argentina
Published: December 2021

XIX Congreso Argentino de Diabetes
Simposio: el embarazo de Iris. Función de la célula beta del feto, epigenética y otras variables
Authors: Jawerbaum Alicia
Published: December 2021

El páncreas fetal comienza su desarrollo durante el primer trimestre de embarazo. La historia clínica de Iris nos muestra que es una paciente que, si bien bajó de peso en forma preconcepcional, en el primer trimestre de embarazo presenta obesidad y en el segundo trimestre de embarazo desarrolla diabetes gestacional (DG). En el primer trimestre, su obesidad conducirá a un entorno prooxidante y proinflamatorio intrauterino que podrá inducir fallas en el proceso de diferenciación de la célula beta pancreática en la etapa embrionaria y afectar la regulación fina de la interrelación de las células del islote pancreático durante su desarrollo. Éstas son posibles causas del elevado riesgo de la disfunción metabólica que tendrá la progenie de Iris a lo largo de su vida.Cuando en su segundo trimestre de embarazo la paciente Iris desarrolla DG, a los adversos efectos del entorno prooxidante y proinflamatorio intrauterino que se exacerban a medida que progresa el embarazo, se suma el efecto adverso de la hiperglucemia. Este exceso de glucosa circulante será transportada a través de la placenta, estimulando en forma temprana a un páncreas que si bien presenta inmadurez, es funcional. Esto generará un exceso de insulina fetal, promotora del sobrecrecimiento y adiposidad fetal, y una desregulación de la interrelación de órganos con función metabólica. Estos cambios conducirán a la programación del metabolismo fetal, que será evidente a lo largo de la vida de la descendencia de Iris.Los mecanismos implicados en el impacto del entorno prooxidante y proinflamatorio durante el desarrollo de la célula beta y la conformación del islote son múltiples, siendo relevantes los cambios en la regulación epigenética y en la regulación de los múltiples factores de transcripción que conducen al desarrollo del páncreas endocrino. Se discutirá el impacto de agentes nutrigenómicos capaces de regular el desarrollo del páncreas endocrino y prevenir la programación fetal.
Simposio: el embarazo de Iris. Función de la célula β después del embarazo, prevención de diabetes mellitus tipo 2, intervención en estilo de vida y/o farmacológica
Authors: Faingold Cristina
Published: December 2021

La diabetes mellitus gestacional (DG), definida como cualquier grado de intolerancia a la glucosa con inicio o primer reconocimiento durante el embarazo, se caracteriza por defectos maternos subyacentes en la respuesta de las células β a la insulina durante el embarazo. Las mujeres con antecedentes de DG tienen un riesgo siete veces mayor de desarrollar DM posparto en comparación con aquellas sin DG.Se han identificado varios factores de riesgo para la diabetes posparto, incluida la edad materna, los niveles de glucosa durante el embarazo, los antecedentes familiares de DM, el índice de masa corporal antes y después del parto, los patrones dietéticos, la actividad física y la lactancia. Estudios genéticos revelaron que la DG comparte variantes genéticas comunes con la DM2. Varios ensayos de intervención en el estilo de vida que tenían como objetivo mejorar los factores de riesgo modificables, incluida la dieta, el ejercicio y la lactancia materna, lograron reducir la incidencia de DM posparto, reducir el peso y otras morbilidades relacionadas con la obesidad.El Programa de Prevención de la Diabetes (DPP) es un ensayo representativo, intervencionista, aleatorizado, multicéntrico, que tenía como objetivo demostrar que las modificaciones intensivas del estilo de vida (IEV) o la metformina podrían prevenir el desarrollo de DM en hombres y mujeres de alto riesgo con intolerancia a la glucosa. Luego de 10 años de seguimiento, las mujeres con antecedentes de DG asignadas al placebo tenían un riesgo 48% mayor de desarrollar DM en comparación con aquellas sin antecedentes de DG. En mujeres con antecedentes de DG, la IEV y la metformina redujeron la progresión a DM en comparación con el placebo en un 35% y un 40% respectivamente. Entre las mujeres sin antecedentes de DG, la IEV redujo la progresión a DM en un 30% y la metformina no redujo la progresión a diabetes. La presión arterial sistólica y diastólica y los niveles de triglicéridos también fueron más bajos en sujetos que se sometieron a modificaciones en el estilo de vida. La lactancia materna proporciona beneficios tanto a la madre como a su descendencia. La lactancia de más de tres meses redujo la DM posparto en un 46% en un estudio alemán. Otros estudios de intervención como el Troglitazone in Prevention of Diabetes (TRIPOD) y el Pioglitazone in Prevention of Diabetes (PIPOD) demostraron una tasa de incidencia de diabetes del 4,6% por año, que fue considerablemente más baja que la tasa de DM para el grupo placebo.Aunque sabemos que la prevención de la DM es posible, en la práctica clínica, la pérdida en el seguimiento de las mujeres con DG después del parto es problemática. La mayoría de las mujeres con DG comprende la asociación entre DMG y DM posparto, aún así no perciben el mayor riesgo que tienen de desarrollarla. Las tasas de reclasificación posparto oscilan entre el 19 y 73%, que en general son bajas en comparación con las expectativas.
Uma equipe colaborativa enfrentando a pandemia: a perspectiva de uma terapeuta ocupacional em um serviço de saúde mental infantil/A collaborative team facing the pandemic: the perspective of an occupational therapist in children's mental health service
Authors: Bissa Cinthia Alves de Araújo , Uchôa-Figueiredo Lucia da Rocha
Published: December 2021

Objetivo: apresentar como uma equipe de saúde mental infantil se reinventou para manter o cuidado, em meio à pandemia de COVID-19, e destacar a participação da terapia ocupacional nesse processo. Síntese dos elementos do estudo: foi necessária parceria e diálogo para superar os desafios, reconstruir o fluxo interno e adotar novas ações. A terapia ocupacional se destacou devido suas contribuições para qualificar e adaptar o cotidiano da população atendida, bem como sua preocupação, sempre presente, com as pessoas em maior vulnerabilidade.  Conclusão: A pandemia evidencia a necessidade de uma equipe colaborativa, baseando-se na integralidade e colocou o trabalho da terapia ocupacional em evidência.Palavras-chave: Terapia Ocupacional. Equipe multiprofissional. Covid-19. Saúde MentalAbstractObjective: Presenting how a team of children’s mental health workers reinvented themselves in order to keep on providing care in the midst of the COVID-19 pandemic and to highlight the participation of occupational therapy in this process. Synthesis of the study elements: partnership and dialogue were needed to overcome the challenges, rebuild the internal flow, and adopt new actions. Occupational therapy stood out due to its contributions to qualify and adapt the daily life of the population served, as well as its ever-present concern for the most vulnerable people. Conclusion: Pandemic highlights the need for a collaborative team, based on integrality, and put the work of occupational therapy in evidence.Keywords: Occupational Therapy. Health Care Team. COVID-19. Mental Health.  ResumenObjetivo: Presentar como un equipo de salud mental infantil se reinventó para mantener los cuidados en medio a la pandemia de COVID’19 y destacar la participation de la terapia ocupacional en este proceso.. Síntesis de los elementos de estudio: Ha sido necesario trabajo en equipo y dialogo para superar los desafíos, reconstruir el eje interno y adoptar nuevas acciones. La terapia ocupacional se destacó debido sus contribuciones para calificarse y adaptarse al cotidiano de la población atendida, así como, su preocupación siempre presente con las personas con nivel más grande de vulnerabilidad. Conclusión: La pandemia evidencia la necesidad de un equipo colaborativo, basándose en la integridade, y poner en evidencia el trabajo de la terapia ocupacional. Palabras clave: Terapia Ocupacional. Equipo Multiprofesional. Covid-19. Salud Mental
Terapia ocupacional e saúde mental dos atingidos por barragem em brumadinho/Occupational therapy and mental health of people affected by the tailings dam in brumadinho city
Authors: Gontijo Cançado Araújo Nathália , Rodrigues Ellen Naiara Oliveira , Maxta Bruno Souza Bechara
Published: December 2021

Em 25 de janeiro de 2019 ocorreu o rompimento da barragem de rejeitos de minério Córrego do Feijão I de propriedade da empresa Vale/SA em Brumadinho – MG. O desastre-crime resultou em perdas humanas, materiais e ambientais em todas as comunidades que vivem às margens do Rio Paraopeba. Pretende-se registrar considerações sobre o trabalho de terapeutas ocupacionais em situações de desastres e emergências advindas da mineração bem como expor os desafios da transformação do processo de saúde e doença junto aos atingidos.Palavras-chave: Atingidos por Barragem. Terapia Ocupacional. Saúde Mental. Atenção Básica. Mineração. AbstractOn January 25th, 2019, a tailings dam, owned by the company Vale SA in Brumadinho-MG, broke down. The crime-disaster resulted in human, material and environmental losses in all communities that live on the shore of the Paraopeba River. This article intends to present considerations about occupational therapists' work who have been acting on situations of disasters and emergencies coming from mining, moreover expose the challenges of transforming the health and disease process with people affected by the tailings dam.Keywords: Dam Affected. Mental Health. Primary Health Care. Occupational therapy. Mining. ResumenEl 25 de enero del año 2019 ocurrió una ruptura en la represa de minería "Córrego do Feijão" de propiedad de la empresa Vale/SA en Brumadinho-MG. El desastre-crimen resultó en pérdidas humanas, materiales y ambientales para todas las comunidades que viven en las márgenes del Río Paraopeba. Registramos consideraciones acerca del trabajo de los terapeutas ocupacionales en situaciones del desastre y emergencias provenientes de la explotación de los minerales, igualmente exponemos desafíos asistenciales para la transformación de los procesos salud y enfermedades junto a los que sufrieron con la ruptura.Palabras-claves: Afectados por la represa de minería. Salud Mental. Atención Primaria en Salud. Terapia Ocupacional. Minería.
Review on Prevalence of Haemonchus Contort us in Ethiopian
Authors:   Ambo University, School of Veterinary Medicine and Department of Veterinery Parasitology, Ethiopia, Tilahun Tadesse
Published: December 2021

In the 17th century, Robert Hooke invented the microscope and our life understanding and disease increased. Further understanding of the invisible, microscopic world has been occurred after the establishment of modern microbiology in the 19th century by Louis Pasteur and Robert Koch. Thanks to modern technology, there have been nearly 300 species of parasitic helminths known to be human parasite. Additionally, livestock, crops and pets are all victims of parasitic helminths, which cause extreme effects on the human population as well [1].
Pengembangan Buku Pendamping Bahan Ajar Tematik Kelas III SD/MI Berbasis Kearifan Lokal Daerah Kalimantan Barat
Authors: Mansur Mansur , Kartini Kartini
Published: December 2021

Penelitian ini bertujuan untuk mengembangkan kearifan lokal dalam bahan ajar tanpa harus menghilangkan substansi materi yang menjadi tujuan kurikulum. Adapun metode yang digunakan dalam penelitian ini adalah metode Research and Development Model 4 D yakni Define, Design, Development and Dissemination. Sedangkan instrumen atau alat pengumpulan datanya adalah, dokumentasi dan angket validasi untuk kelayakan buku pendamping yang dikembangkan. Hasil penelitian ini adalah tersusunnya 8 buah buku pendamping untuk pembelajaran tematik berbasis kearifan lokal daerah Kalimantan barat untuk Kelas III, dengan 4 aspek penilaian yang meliputi penilaian terhadap aspek isi materi rata aspek penilaiannya 4.68 setara dengan 93.75 % (Valid/ Layak digunakan), aspek  kelayakan penyajian  materi pelajaran yang sesuai dengan buku pembelajaran tematik kemendiknas tahun 2018 rata-rata penilaian 4.76  setara dengan 95 %  ( Valid/Layak untuk digunakan). aspek kelayakan tampilan desain buku pada pengembangan bahan ajar berbasis kearifan lokal diperoleh nilai rata-rata 4.8 setara dengan 96.7 % (Valid/ Layak untuk digunakan), aspek kelayakan bahasa yang digunakan pada pengembangan bahan ajar berbasis kearifan lokal diperoleh nilai rata-rata 4.64 setara dengan 96.7  % (Valid / layak untuk digunakan).
Dampak Layanan Transportasi Online Terhadap Kesejahteraan Perekonomian Masyarakat Kota Mojokerto Melalui Kesempatan Kerja
Authors: Huda Khasbulloh , Fitriyani Zenita Afifah , Sholeh Rachmad , Johan Effendi Mohammad
Published: December 2021

Penelitian ini bertujuan untuk mengetahui dampak layanan transportasi online terhadap kesejahteraan perekonomian masyarakat Kota Mojokerto melalui kesempatan kerja. Penelitian ini dilakukan dengan pendekatan kuantitatif yang menggunakan metode survey. serta menggunakan metode pengambilan data random sampling. Sedangkan pengukuran menggunakan skala likert. Adapun metode pengumpulan data menggunakan kuesioner. Metode analisis data dalam penelitian ini menggunakan PLS (Partial Least Square) dengam program smartPLS 3.0. Hasil penelitian menunjukkan bahwa variabel layanan transportasi online memiliki pengaruh langsung terhadap kesempatan kerja pada masyarakat Kota Mojokerto dengan perolehan T stastistik sebesar 9,007 (P value = 0,000). Layanan transportasi online memiliki pengaruh langsung terhadap kesejahteraan perekonomian masyarakat Kota Mojokerto dengan T stastistik sebesar 10,746 (P value = 0,000). Kesempatan kerja memiliki pengaruh terhadap kesejahteraan perekonomian masyarakat kota Mojokerto dengan T stastistik sebesar 11,471 ( P value = 0,000). Layanan transportasi online memiliki pengaruh terhadap kesejahteraan perekonomian masyarakat Kota Mojokerto melalui kesempatan kerja dengan T stastistik sebesar 7,193 (P value = 0,000).
Implementasi Pendidikan Karakter Berdasarkan Nilai Pancasila di Era Globalisasi
Authors: Herlina Lin , Dewi Dinie Anggraeni
Published: December 2021

pendidikan karakter merupakan salah satu hal penting bagi kehidupan bangsa Indoneisa. Pancasila dijadikan sebagai dasar negara, sekaligus juga merupakan ideologi negara. Selain itu pancasila juga merupakan way of life bangsa indonesia. Dengan perkembangan teknologi yang semakin pesat maka percepatan globalisasipun demikian. Artikel ini akan menjabarkan implemntasi nilai pancasila yang harus diterapkan agar nilai-nilai pancasila tetap  kokoh maka diperlukan  pengokohan nilai-nilai pancasila tersebut kepada generasi penerus bangsa khususnya kepada para peserta didik  dari jenjang sekolah dasar hingga ke jenjang perguruan tinggi. Hal tersebut dapat diupayakan dengan mempelajari mengenai kewarganegaraan dan juga pancasila. Artikel ini dibuat  untuk tetap menjadikan pancasila sebagai pedoman dalam kehidupan sehari-hari sehingga menjadikan manusia yang beriman dan bertakwa kepada tuhan yang maha esa, berakhlak mulia, mandiri,bertanggung jawabm demokratis, dan menjadi warga negara yang menjunjung tinggi nilai-nilai pancasila. Artikel ini dibuat dengan metode kualitatif prngumpulan data-data melalui kajian pustaka dengan sumber dari berbagai daterasi yang terdapat kajian mengenai pengimplementasian nilai pancasila di era globalisasi seperti dalam buku, artikel, dan jurnal.