bluuebunny/crossref_metadata_2025 huggingface dataset:
Las fortificaciones del campo de Montiel (SS. VIII al XVI): historia, arqueología y análisis constructivo
Authors:   ,   Universidad de Castilla-La Mancha, Gallego Valle David
Published: March 2022

El principal objetivo de este trabajo de tesis está ligado al estudio de los procesos constructivos de las fortificaciones medievales de nuestra de comarca, como base para la reconstrucción histórica de los edificios de una manera particular y del periodo medieval en general. En este sentido, nuestra intención es responder a una serie de interrogantes cómo ¿qué papel tienen las fortificaciones en la evolución del poblamiento y la organización de un espacio histórico?; ¿cuándo surgen los primeros recintos militares medievales?, ¿qué tipos de construcción son propios de una etapa o si existen pervivencias? ¿cómo puede ayudar la historia de la construcción a conocer la evolución histórica de un territorio?
Planejamento Colaborativo das Aulas para Alunos com NEE no Curso Técnico
Authors: Galter Dalmonech Hildo Anselmo , Dalmonech Jaqueline Zanotti , Goularte Marko Aurélio , Reis Luciléa Silva dos
Published: March 2022

O objetivo foi demonstrar a importância do planejamento colaborativo entre o professor de AEE e o professor da disciplina no planejamento das aulas para alunos com NEE. A pesquisa se caracteriza como um estudo de caso no qual buscou mitigar as adaptações propostas pela professora de AEE para um aluno com NEE. A pesquisa de campo foi realizada com uma professora de AEE especialista, com 10 anos de experiência na área, e uma professora Doutora, responsável pela disciplina Cafeicultura. Como principais resultados, foi verificado que a atuação em sala de aula precisou ser mais direta. Verificou-se também que é preciso considerar as possibilidades de desenvolvimento, compreender e aceitar que a aprendizagem ocorre de forma diferente dos demais alunos. Foi, ainda, observado, que o trabalho em conjunto com uma colaboração mutua, procurando traçar estratégias pedagógicas que se adequam as necessidades individuais, trouxeram avanços na aprendizagem do mesmo.
Vortex vertical axis wind turbines for autonomous power supply
Authors: Shishkin Nikolai , Ilyin Roman
Published: March 2022

The paper gives an overview of vertical axis wind turbines. We have researched efficiency of a combined Darrieus and Savonius H-rotor with flaps having triangular parts. For the comparison, we consider vortex wind turbines with horizontal axis propeller rotors. It was proven that vertical axis wind turbines with combined rotors are more energy efficient based on experimentally found results. The proposed vortex wind turbines can be used for autonomous power supply, especially in remote areas.
Działalność Biblioteki Uniwersytetu Łódzkiego w okresie pandemii (marzec 2020 – czerwiec 2021 r.)
Authors: Kowalewska Urszula
Published: March 2022

Pandemia COVID-19 zdezorganizowała działalność bibliotek. Stanęły one przed wyborem dotyczącym tego, które usługi mogą bezpiecznie oferować użytkownikom, aby zapewnić im stały dostęp do potrzebnych informacji. Artykuł przedstawia funkcjonowanie Biblioteki Uniwersytetu Łódzkiego (BUŁ) w czasie trwania pandemii. Prezentuje zastosowane rozwiązania i usługi dostosowane do sytuacji epidemiologicznej, pozwalające czytelnikom na satysfakcjonujące i bezpieczne korzystanie z zasobów Biblioteki UŁ.
„Precypitacja”, doświadczenie ekstremalne, zwrotnica i zasób: choroba z perspektywy biograficznej
Authors: Fiternicka-Gorzko Magdalena
Published: March 2022

Artykuł jest prezentacją wyników badania empirycznego poświęconego rekonstrukcji sposobów włączania w całość jednostkowej biografii doświadczeń związanych z chorobami przez osoby niedefiniujące się zasadniczo jako chore. Źródłem danych były wywiady zebrane w ramach badania oral history wśród mieszkańców województwa zachodniopomorskiego poddane analizie wtórnej.

Indukcyjnie wygenerowane kategorie „zwyczajnej dolegliwości”, „precypitacji”, „doświadczenia ekstremalnego” i odmian „wstrząsającego przeżycia” odsłaniają kompleksy znaczeń wiązane z chorobą. Kategoria „zwrotnicy” ukazuje postrzeganie wpływu choroby na losy życiowe, natomiast kategoria „zasobu” uwikłanie choroby w ludzkie działania (tego, co ludzie robią z chorobą).
El comercio según Platón: ¿factor de división o de comunidad política?
Authors: Helmer Etienne
Published: March 2022

Suele pensarse que los filósofos griegos desprecian tanto el comercio al por mayor entre las ciudades, como el comercio al por menor dentro de las ciudades. De acuerdo con esta larga tradición interpretativa, Platón se conforma a la poesía homérica y hesiódica al respecto: el comercio tiene la reputación de ser un oficio asociado con la deshonestidad y el afán de lucro, por lo cual se estima que propicia más la división y el conflicto que la harmonía y la cohesión social. Sin embargo, una lectura minuciosa de algunos pasajes de los Diálogos de Platón, y particularmente de la República, revela otra vertiente de su acercamiento al comercio y su influencia sobre la cohesión de la pólis. Intentando resaltar un aspecto que suele ser ignorado por la mayoría de los intérpretes, se propone demostrar en este artículo que Platón ve en el comercio en sí mismo un factor que permite formar y mantener la comunidad de la pólis. Esta apreciación reposa en la convicción de Platón en que el carácter político del ser humano se forja a través de múltiples intercambios, entre los cuales el comercio juega un papel fundamental.
Three Aspects of the Linguistic Communion (Koinōnia) in Plato’s Sophist: Articulation of Letters, Predication of Names and Accord (Homologia) of Logoi
Authors: Karagöz Taha
Published: March 2022

In the Sophist, Plato presents the possibility of the separation of things in relation to each other based on the communion (koinōnia) of logos. In this study, I discuss the linguistic communion revealed in the dialogue by illuminating its three fundamental aspects: (1) Articulation of letters in names as communion on the syntactic level, (2) Predication of names in logoi as communion on the semantic level, (3) Homologoi of logoi as the ultimate communion of language. I thus conclude that these three linguistic aspects are interdependent.
Heat Tolerance and Effect of High Temperature on Floral Biology and Physiological Parameters in Rice: A Review
Authors: Jayaraman Vanitha , Ramachandran Mahendran
Published: March 2022

Rice (Oryza sativa L.) is one of the major cereal staple food crops consumed by more than 50 per cent of the world’s population. Due to global climatic changes, the crop has to withstand higher temperatures in the near future. In India, rice cultivation is more affected by climate change and it contributes to yield loss and in severe cases results in crop failure both of which leads to economic losses. Grain yield declined by 10% for each 1oC increase in minimum temperature in the dry season whereas the effect of maximum temperature was insignificant. Significant variation exists among rice germplasm in response to high temperature stress. Producing an economically significant yield under heat stress conditions depends on floral biology of rice and several plant physiological parameters and mechanisms that contribute to heat tolerance in the field, such as photosynthesis, chlorophyll content, canopy temperature depression and concomitant increases of transcripts coding for proteins involved in protection. According to the objectives of this study, the literature pertaining to the aspects of heat tolerance and effect of high temperature on floral biology and physiological parameters in rice is briefly reviewed.
Transformation of Scientific Activity: Network Direction. Review of the book “Detsentralizovannaya setevaya organizatsiya nauchnogo soobshchestva: perspektivy i problem” by A. V. Oleskin
Authors: Grishakina Ekaterina
Published: March 2022

The changes taking place in the modern world require a revision of the methods for implementing various types of social activities, including scientific ones. Established hierarchical ties among team members, teams, organizations, collaborations, countries cannot always provide an answer to the global challenges facing society. A restart of all communication channels is required. One of the ways to improve the efficiency of interaction among all interested participants in various processes is the formation and development of network forms of organizing activities. The purpose of this work is to analyze the main decentralized network scenarios of research, expert and scientific-commercial activities and identify the most suitable for their implementation. The author of the book defines as one of the options for a decentralized network organization that is effectively used in research activities, “hirama” – a network structure with several partial creative leaders, which allows solving various subtasks without separating the functions of team members: all network members work in parallel on several subproblems of one task. Elements of the alternative variants of network structures considered by the author can also be used in the formation of research teams to solve research problems. Thus, the author of the study reveals the options for the network organization of various types of social activity, including scientific, and determines the boundaries of their application in human activity.
Analysis of Performance Indicators of Research Organizations
Authors: Eroshin Sergey
Published: March 2022

The article discusses modern approaches to assessing the effectiveness of scientific organizations. The reasons for their insufficient innovative activity are analyzed. Consideration of the issues of the effectiveness of organizations carrying out scientific research is proposed to be carried out in three sections: academic institutions, universities, organizations of the military-industrial complex. Differences in the organization of management systems in the field of the defense industry and in the field of institutions of civilian research areas are formulated. The need to improve the system of indicators of the effectiveness of universities is argued. An attempt was made to consider the problematic issues of the development of the system of science and education in the economic context. On a broader level, the mechanism for introducing scientific developments in conjunction with the financial and economic consequences of innovations for society is described discursively. The existing form and content of the main economic relations operating in the country are identified as the main reasons for the insufficient demand for science in society.
On the Boundary between Fundamental and Applied Economic Studies
Authors: Klistorin Vladimir
Published: March 2022

The paper discusses criteria allowing consideration of applied economic studies as a special group of research. This is especially important, since applied research currently makes up most of the work performed. Many professional economists are involved in their implementation and many academic scientists participate periodically. It is shown that objectives of the research would not be regarded as a differentiating criterion of fundamental and applied works as well as a share of empirical research in a total volume of studies – as a powerful criterion. The major criterion is the presence of the customer and technical specifications for execution of works approved by him and specifying the form of presentation of the results,type and volume of the final document, methodology and timing of the work, etc. The results obtained in fundamental research are published in the open press, while the results of applied work become the customer’s property. The former is directed to the scientific community, the latter – to satisfy the needs of a particular subject. The paper offers a classification of applied economic research and it describes the main problems of interaction between the customer and contractor involved in various types of applied works. For example, the differences in the values and language used by the customer and contractor is advisable to be considered for making successful their collaboration. The widely spread applied economic research increasingly affect the motivation of scientists as well as the training and education of scientific personnel and specialists. The latter tends to focus on teaching instrumental
Pruning residuals: their role in the micronutrient budget of Clementine mandarin (Citrus reticulata Blanco)
Authors: BARLAS Neriman Tuba
Published: March 2022

Objective: The objective of this study was to determine the micronutrient (Fe, Cu, Mn and Zn) amounts removed with pruning residuals in Clementine mandarin (Citrus reticulata Blanco) grafted on bitter orange.

Material and Methods: In order to meet the above objective , at the end of two production seasons (2015 and 2016), measurements and analyses were carried out by collecting pruning residual samples from 50 groves located in the province of İzmir and Aydın (Turkey).

Results: While the biomass value varied between 2.90 and 4.90 kg/tree in the 1st year, it varied in the range of 3.00-5.00 kg/tree in the 2nd year. The concentration (mg kg-1) values for the first year were as Fe: 44-115, Cu: 11-32, Mn: 33-75, Zn: 17-26, while these for the second year were Fe: 48-101, Cu: 16-38, Mn: 40-88 and Zn: 20-30. The yield value was 64-102 kg/tree for the 1st year and 65-94 kg/tree for the 2nd year.

Conclusion: The mean values of the microelement amounts removed with pruning residuals may be listed as Fe > Mn > Zn = Cu for both years. The micronutrient amount removed with pruning residuals (g/tree) was found to be Fe: 0.15-0.41, Cu: 0.04-0.13, Mn: 0.12-0.3 and Zn: 0.05-0.13 for the 1st year and Fe: 0.16-0.44, Cu: 0.06-0.16, Mn: 0.15-0.36 and Zn: 0.07-0.13 for the 2nd year. It is suggested that these amounts should be included in plant fertilization programs.
On the regulatory and legal aspects of the implementation of inclusive education in the Republic of Kazakhstan
Authors:   Regional psychological and pedagogical consultation, Karaganda region, Republic of Kazakhstan, Kayralapova Raushan K. , Tishina Oksana V. ,   Regional psychological and pedagogical consultation, Karaganda region, Republic of Kazakhstan, Kayralapova Malika E. ,   Novosibirsk State Pedagogical University
Published: March 2022

In this article, we will consider inclusive education as one of the strategic directions of the development of the education system in the Republic of Kazakhstan, we will reveal the main aspects of the development of inclusive education. The analysis of the regulatory and legal framework for the implementation of inclusive education in Kazakhstan, in particular the Law "On Amendments and Additions to Certain Legislative Acts of the Republic of Kazakhstan on Inclusive Education".
Studying in an inclusive educational institution: the attitude of parents
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Volosova Svetlana A.
Published: March 2022

The article presents the results of a study of the attitude of parents to teaching their normally developing children together with peers with special educational needs in an inclusive educational institution. The data obtained allowed us to make a comparative analysis of the parents 'awareness of learning in an inclusive educational institution, the opportunities for their child to study at school, and the parents' ideas about the difficulties that the child experiences in the process of joint learning.
Features of the formation of motivational readiness for school of preschoolers with mental retardation in the conditions of a combined group
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Simanovskiy Andrey E. , Kudryavtseva Svetlana S. ,   Kindergarten № 26, Yaroslavl
Published: March 2022

The article is devoted to the peculiarities of the formation of motivational readiness for school of preschoolers with mental retardation in the conditions of a combined group. The structure of the inner position of the student is considered, a study of the motivational readiness for school of preschoolers with mental retardation is given.
Topical issues of functional literacy of persons with special psychophysical development in the social and personal sphere of life
Authors:   Academy of Postgraduate Education, Republic of Belarus, Zaytsev Igor S.
Published: March 2022

The article is devoted to the problem of the formation of functional literacy in children with special psychophysical development. From this point of view, such an important area as the readiness for professional self-determination is considered. The positions of readiness for professional activity, as significant components of the social and personal sphere of life, are presented, guidelines for correctional and educational work on the formation of readiness for professional selfdetermination in conditions of psychophysical disorders are outlined.
Problems of the formation of professional competencies of teachers-defectologists in the context of distance learning
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Vacheyan Larisa A. , Zavertkina Lyubov V. ,   Yaroslavl state pedagogical university named after К. D. Ushinsky
Published: March 2022

The article presents the characteristics of the distance learning form; lists the main distance educational technologies; reveals the essence, features and possibilities of using the Mirapolis environment. The results obtained during the survey of students were processed using the Fisher criterion. It is indicated that professional skills are formed by direct interaction with children with disabilities.
Networking activation as an important part of the quality training course for bachelors and masters of special (defectological) education
Authors:   Moscow pedagogical state university, Vovnenko Kseniya B. , Yakhnina Elena Z. ,   Moscow State Pedagogical University
Published: March 2022

The article analyzes the actual problems the improving networking activation of the University with partner organizations in the training course for bachelors and masters of special (defectological) education. The experience of Inclusive Education and Deafpedagogy Department of the Defectology Faculty is presented. The training course for practice-oriented postgraduate including e-learning and distance educational technologies are described.
Digital technology at the work of a speech therapist
Authors:   Yaroslavl State Pedagogical University named after K.D. Ushinsky, Shabalina Svetlana A. , Satina Darya V. ,   Yaroslavl state pedagogical university named after К. D. Ushinsky
Published: March 2022

For the education, development and, if necessary, correction of children’s impaired development - generation growing in an information-rich environment, there is a need to change the education system, including special education. The emphasis is the computerization of education. The article provides an overview of currently available communication platforms and tools for online speech correction.
The Relationship between Physical Activity and FEV1/FVC in Asthmatics
Authors: Nawangasri Andis Putri , Budiono Budiono , Bakhtiar Arief , Sutikno Budi , Suryaningrum Esti Maulidya , Damayanti Dahlia
Published: March 2022

Background: Physical activity is any body movement that requires energy expenditure. Minimum physical activities per day can bring good impact for asthmatic patients (e.g.,reduce asthma symptoms). Many asthmatic patients limit their physical activity, so they tend to be inactive.Aim: To analyze the relationship between physical activity level and FEV1/FVC in asthmatics.Material and methods: This was an analytic observational study with a cross-sectional design. The number of participants in this study was 16 respondents (13 females and 3 males) who were recruited based on inclusion and exclusion criteria. The independent variable in this study is levels of physical activity and the dependent variable is FEV1/FVC values. This study study used the International Physical Activity Questionnaire (IPAQ) short form and spirometry test. The data were analyzed with Spearman's rho test.Result: There was a strong association between levels of physical activity with FEV1/FVC values (p=0,012).Conclusions: Increasing level of physical activity in asthmatics can improve their lung function showed by increased FEV1/FVC values.
Breakthroughs of Imagination About China in the Field of Video Social Softwares Around EU Region---- A Case Study of Youtube and Kwai
Authors: Li Wenqi
Published: March 2022

With the continuous popularity of network technology, social media has become an important platform for people to acquire information in the web space, participate in interactions, and share discussions, which has brought about a change not only in people's daily life but also in international communication. This paper analyzes Chinese images through video social software such as Youtube and Kwai. Mainly focused on the cognitive breakthrough imagined in China after the use of video social software in the European Union to study the perceptions of Chinese images in the original European Union region, how these perceptions changed after the use of video social software, and why China used different algorithms when making video social software outputs. To construct a new idea for the international diffusion of Chinese image.
Obtaining and Characterization of High-Quality Recycled Graphites From Different Types of Spent Batteries
Authors: Alcaraz Lorena , Díaz-Guerra Carlos , López Félix A.
Published: March 2022

Spent batteries recycling is an important way to obtain low-cost graphite. Nevertheless, the obtaining of crystalline graphite with a rather low density of defects is required for many applications. In the present work, high-quality graphites have been obtained from different kinds of spent batteries. Black masses from spent alkaline batteries (batteries black masses, BBM), and lithium-ion batteries from smartphones (smartphone black masses, SBM) and electric and/or hybrid vehicles (lithium-ion black masses, LBM) were used as starting materials. A hydrometallurgical process was then used to obtain recycled graphites by acidic leaching. Different leaching conditions were used depending on the type of the initial black mass. The final solids were characterized by a wide set of complementary techniques.
First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras
Authors: Ortiz Bryan , Laínez-Arteaga Isis , Galindo-Morales Celeste , Acevedo-Almendárez Lilia , Aguilar Kateryn , Valladares Diana , López Miriam , Fontecha Gustavo
Published: March 2022

Mucormycoses are rare but serious opportunistic fungal infections caused by filamentous organisms of the order Mucorales. Here we report the first molecular identification of Rhizopus oryzae (heterotypic synonym Rhizopus arrhizus), R. delemar, and Apophysomyces ossiformis as the etiological agents of three cases of severe mucormycosis in Honduras. Conventional microbiological cultures were carried out, and DNA was extracted from both clinical samples and axenic cultures. The ITS ribosomal region was amplified and sequenced. Molecular tools are suitable strategies for diagnosing and identifying Mucorales in tissues and cultures, especially in middle-income countries lacking routine diagnostic strategies.
Effects of Education Programs on School Students' Knowledge, Attitude, and Practice Regarding First Aid for a Choking Person in Saudi Arabia
Authors: Abdelmalik Mohammed A. , Mohammead Mohammead O. , Mohammed Almoez M. , Abdalla Adel M. , Saeed Abdalrahman A. , Sambu Binyameen M. , Abbakr Ibrahim A. , Beraima Mohamed A.
Published: March 2022

Choking and foreign body aspiration are significant causes of mortality and morbidity in young youngsters. This study aimed to investigate the effects of education programs on school students ' knowledge, attitude, and practice towards a choking person. This quasi-experimental study with a pretest-posttest control group design included a total of 282 school students. The students were divided into an intervention group (n = 141) and a control group (n = 141). After both groups completed the pretest, the intervention group received an education program on first aid for a choking person. Then, both groups were subjected to a posttest at the end of the program. The descriptive and inferential statistics analyzed the data. There were no significant differences between the two groups within the study parameters at the pretest (P = > 0.05). However, at posttest, a significant difference was observed in the knowledge (p = 0.001), attitude (p = 0.024), and practice (p = 0.001) of the intervention group compared to the control group. The intervention group showed significant improvement in the students’ knowledge, attitudes, and practices regarding first aid for a choking person. We suggest a continuous training program to improve the competency of first aid for a choking person.
Effects of Chlorothalonil Application on the Physio-Biochemical Properties and Microbial Community of a Yellow-Brown Loam Soil
Authors: Jiang Jinlin , Yang Yuwen , Wang Lei , Cao Shaohua , Long Tao , Liu Renbin
Published: March 2022

To get a better knowledge of the effects of residual chlorothalonil on soil characteristics and soil microbial communities, we evaluated the dissipation of chlorothalonil and the effects of different chlorothalonil concentrations on soil respiration, enzyme activities, and microbial community structure in yellow-brown loam soils. Bacterial and fungal soil communities were examined using traditional plate counting and polymerase chain reaction-denaturing gradient gel electrophoresis (PCR–DGGE) methods. Soil properties and the results of DGGE band analysis were both used to estimate the status of the soil microbial ecosystem. The results show that residual chlorothalonil has considerable effects on soil respiration, enzymatic activities, and microbial community structure. In particular, soil respiration and phosphatase activities were increased, while saccharase activity, microbial biomass, and microbial community diversity were decreased by increasing levels of chlorothalonil treatment. Correlation analyses revealed that the application of chlorothalonil was significantly correlated with the change of the soil respiration, urease activity, sucrase activity, soil culturable bacteria and culturable fungi biomass. We conclude that residual chlorothalonil is directly related to soil respiration, enzyme activities, and microbial community structure.
Synthesis, Computational and Nanoencapsulation Studies on Eugenol-Derived Insecticides
Authors: Coelho Catarina , Pereira Renato , Vieira Tatiana , Teixeira Cláudia , Fernandes Maria , Rodrigues Ana , Pereira David , Sousa Sérgio , Fortes António , Castanheira Elisabete , Gonçalves Maria
Published: March 2022

A new set of alkoxy alcohols were synthesised by reaction of eugenol oxirane with aliphatic and aromatic alcohols. These eugenol derivatives were evaluated against their effect upon the viability of the insect cell line Sf9 (Spodoptera frugiperda).The most promising compounds, 4-(3-(tert-butoxy)-2-hydroxypropyl)-2-methoxyphenol and 4-(2-((4-fluorobenzyl)oxy)-3-hydroxypropyl)-2-methoxyphenol were submitted to in silico assays to predict possible targets. Thought an Inverted Virtual Screening approach, 23 common pesticide targets were screened and the top 2 targets predicted were further evaluated through molecular dynamics simulations and free energy calculations. In addition, these to eugenol derivatives were subjected to encapsulation and release assays using liposome-based nanosystems of egg phosphatidylcholine/cholesterol (7:3), with encapsulation efficiencies higher than 90% and release profiles well described by both Korsmeyer-Peppas and Weibull models.
Scaled-Up Multi-Needle Electrospinning Process Using Parallel Plate Auxiliary Electrodes
Authors: Beaudoin Étienne J. , Kubaski Maurício M. , Samara Mazen , Zednik Ricardo J. , Demarquette Nicole R.
Published: March 2022

Electrospinning has gained a lot of attention in recent years due to its ability to easily produce high-quality polymeric nanofibers. However, electrospinning suffers from limited production capacity and a method to readily scale up this process is needed. One obvious approach includes the use of multiple electrospinning needles operating in parallel. Nonetheless, such an implementation has remained elusive, partly due to the uneven electric field distribution resulting from the Coulombic repulsion between the charged jets and needles. In this work, the uniformization of the electric field was performed for a linear array of twenty electrospinning needles using lateral charged plates as auxiliary electrodes. The effect of the auxiliary electrodes was characterized by investigating the semi-vertical angle of the spun jets, as well as the deposition area and diameter of the fibers. Finite element simulation was also used to analyze the impact of the auxiliary electrodes on the electric field intensity below each needle. Implementing parallel lateral plates as auxiliary electrodes was shown to help achieve uniformization of the electric field, the semi-vertical angle of the spun jet, and the deposition area of the fibers for the multi-needle electrospinning process. The high-quality morphology of the polymer nanofibers obtained by this improved process was confirmed by scanning electron microscopy (SEM). These findings help resolve one of the primary challenges that have plagued the large-scale industrial adoption of this exciting polymer processing technique.
Development of A Novel Anti-Epcam Monoclonal Antibody for Various Applications
Authors: Li Guanjie , Suzuki Hiroyuki , Asano Teizo , Tanaka Tomohiro , Suzuki Hiroyoshi , Kaneko Mika K , Kato Yukinari
Published: March 2022

The epithelial cell adhesion molecule (EpCAM) is a cell surface glycoprotein, which is widely expressed on normal and cancer cells. EpCAM is involved in cell adhesion, proliferation, survival, stemness, and tumorigenesis. Therefore, EpCAM is thought to be a promising target for cancer diagnosis and therapy. In this study, we established anti-EpCAM monoclonal antibodies (mAbs) using the Cell-Based Immunization and Screening (CBIS) method. We characterized them using flow cytometry, western blotting, and immunohistochemistry. One of the established recombinant anti-EpCAM mAbs, recEpMab-37 (mouse IgG1, kappa), reacted with EpCAM-overexpressed Chinese hamster ovary-K1 cells (CHO/EpCAM) or a colorectal carcinoma cell line (Caco-2). In contrast, recEpMab-37 did not react with EpCAM-knocked out Caco-2 cells. The KD of recEpMab-37 for CHO/EpCAM and Caco-2 was 2.0 × 10-8 M and 3.2 × 10-8 M, respectively. In western blot analysis, recEpMab-37 detected EpCAM of CHO/EpCAM and Caco-2 cells. Furthermore, recEpMab-37 could stain formalin-fixed paraffin-embedded colorectal carcinoma tissues by immunohistochemistry. Taken together, recEpMab-37, established by CBIS method, is useful for detecting EpCAM in various applications.
Gambaran Radiologik Pneumonia pada Anak dengan Menggunakan Foto Thorax dan Ultrasonografi Paru di Rumah Sakit Wahidin Sudirohusodo Makassar
Authors: J Jeri , Asriyani Sri , L Amiruddin , Seweng Arifin
Published: March 2022

Pendahuluan Pneumonia menjadi penyebab utama kematian pada anak di bawah usia 5 tahun selama beberapa dekade. Foto X-ray dada adalah modalitas diagnostik yang paling umum digunakan. Namun, karena efek radiasi sinar-X, ultrasonografi menjadi semakin populer untuk diagnosis pneumonia pada anak-anak. Penelitian ini bertujuan untuk membandingkan dan menilai kesesuaian (agreement) antara hasil pemeriksaan x-ray dada dan ultrasonografi untuk diagnosis pneumonia pada anak-anak. Metode: Penelitian ini dilakukan di Bagian Radiologi Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar dan Rumah Sakit Pendidikan Universitas Hasanuddin Makassar dari bulan Februari sampai April 2020. Jumlah sampel sebanyak 44 pasien berusia antara 1 hari sampai kurang dari 18 tahun. Tes Kappa digunakan untuk menilai kesesuaian antara kedua metode. Hasil: Hasil penelitian menunjukkan bahwa gambaran pneumonia pada anak berdasarkan hepatisasi pada USG paru menunjukkan kesesuaian yang signifikan dengan tanda konsolidasi pada foto thorax (koefisien Kappa = 0,560, p <0,05). Elemen hyperechoic linier pada ultrasonografi paru dengan tanda air bronchogram dan infiltrat pada foto toraks juga menunjukkan kesesuaian yang baik (koefisien Kappa = 0,596, p <0,05). Selain itu, tanda lesi anechoic pada ultrasonografi paru dengan gambar ground glass opacity (GGO) pada radiografi dada menghasilkan koefisien Kappa 0,495 dan p <0,05. Kesimpulan: Pneumonia pediatrik dimanifestasikan pada ultrasonografi sebagai hepatisasi, hyperechoic linear elements, dan pathologic B-line, sedangkan pada rontgen dada dimanifestasikan sebagai konsolidasi dan infiltrat. Kesepakatan yang baik ditemukan antara konsolidasi x-ray dengan hepatisasi pada ultrasonografi, antara elemen hyperechoic linier pada ultrasonografi dengan infiltrat pada x-ray, serta antara lesi anechoic pada ultrasonografi dengan GGO pada rontgen dada
Perbandingan Remifentanil Kontinu 0.15 Mcg/Kgbb dengan Fentanyl 3 Mcg/Kgbb pada Intubasi Endotrakeal Diukur Menggunakan Pupillometer (AlgiScan®)
Authors: Bachtiar Amin Fauzan , A.A Husain Alamsyah , Musba Andi Muhammad Takdir , Ahmad Muh Ramli
Published: March 2022

Introduction: All opioids have varying levels of sedative effects with increasing dosages, although with different strengths. Therefore, the opioid component as a sedative regiment is usually maintained at minimum dose for adequate analgesic with regard to patient comfort. Along with the progress of knowledge, parameters have been found to measure the level of analgesic and sedative. Methods: The principle of measurement is done by using the diameter of pupil and then analyzed through AlgiScan and compared to certain standards. The using of pupilometers AlgiScan in assessing the level of sedative analgesic will reduce the level of subjectivity and errors in measurement. Results: The use of Remifentanil has a faster effect of sedative as proven by lower “AlgiScan” score in the pre-intubation phase. In addition, the use of Remifentanil also provides a hemodynamic view of lower arterial pressure, both pre and post intubation condition. Conclussion: Both Remifentanil and fentanyl are able to provide analgesic with sedative and stable hemodynamics. Remifentanil is proven to be superior with better and faster effect and also faster substance elimination with lower doses.
Quality of Life Difference between Children with Obesity and Children without Obesity
Authors: Tampubolon Nelsi Marintan , Lestari Endang Dewi , Iryawan Andri , Munawaroh Siti
Published: March 2022

ABSTRACT

Introduction: Obesity has become a global health problem because obesity is widespread in many countries and needs to be addressed immediately. Obesity can happen to anyone, including children and adolescents. Obesity in children can affect physical and mental conditions that can affect the quality of life. This study aims to determine whether there are differences in the quality of life of obese and non-obese children in Warga Junior High School Surakarta

Research Methods: An analytical observational study with a cross-sectional approach involved 66 students who were divided into 2 groups. Each group consisted of 33 students who were determined by the purposive sampling technique. Weight measurement was carried out to obtain data on obesity status, while the quality of life of students was measured by the Pediatric Quality of Life Inventory (PedsQL) score version 4.0. The data obtained were analyzed by unpaired t-test.

Results: The obese and non-obese children had a mean PedsQL score of 78,385 and 83,807, respectively. The unpaired t-test in both groups showed a p-value of 0.056.

Conclusion: The quality of life of obese and non-obese students Warga Junior High School Surakarta was not significantly different.

Keywords: Quality of life; obesity; children; adolescentP
Transformation of economic interests in the context of the multipolar world order formation
Authors:   Peoples’ Friendship University of Russia (RUDN University), Chernysheva Anna , Dobrova Katrina ,   Moscow Aviation Institute (National Research University), Dobrova Ekaterina ,   Moscow Aviation Institute (National Research University), Kuznetsova Vera ,   Financial University under the Government of Russian Federation
Published: March 2022

The national interests of countries directly depend on the world order established at a certain time, which constantly transforms, exerting key influence on international economic relations. Understanding the changes of the world order of economic systems allows to understand the transformation of the national interests of countries. All countries can be conventionally divided into attractor countries and satellite countries, which form their national economic interests in accordance with the interests of attractor countries. At the same time, satellite countries can eventually become attractors, and vice versa. The goal of the article is to study the existing world order and its transformation from unipolar to multipolar. To achieve this goal, the authors have explored a change in the concept of national economic interests depending on the influence of global changes in the economy and on the transformation of national economic interests in a particular world order; they have also analyzed the historical change in the world order and determined its current format and assessed the current export-import operations of the leading European countries. It is assumed that the national economic interests of countries have changed as a result of the transition from a unipolar world order to a multipolar world order, including the national economic interests of European countries. As such, the national economic interests of countries should be transformed with due consideration of situational combinations of attractor countries. To test this hypothesis, the authors have analyzed publicly available documents, including statistical data on export-import operations of the key European countries, Russia, China, and the USA. In general, it has been proved that a multipolar world order has formed at the present stage of international economic relations; decision-making at the international level and ensuring national economic interests depend on the situational cooperation of the attractor countries, while some satellite countries are gradually transforming into attractor countries.
Conceptual changes of fiscal regulation of agricultural land use: international experience and Ukrainian practice
Authors:   Kharkiv National Agrarian University named after V. V. Dokuchaiev, Garazha Olena , Shyian Dmytro ,   Simon Kuznets Kharkiv National University of Economics, Cherneha Inna ,   Uman National University of Horticulture, Burliai Alina ,   Uman National University of Horticulture, Zharun Olena ,   Uman National University of Horticulture, Blenda Nataliia ,   Uman National University of Horticulture
Published: March 2022

On the basis of the analysis of international standards of land and real estate valuation and modern scientific researches devoted to the actual issues of land and real estate valuation for fiscal purposes, the authors substantiate the problematic aspects of the formula «land valuation - land payment - budget», which are becoming the basis of public fiscal policy in many countries of the world, and including Ukraine, are grounded. The authors of the article show that the effective valuation of land in the national context depends on the fiscal policy of the state in relation to the tax burden of agricultural enterprises in three-dimensional space, according to the first option - using market prices to determine of the land tax, according to the second option - if it is necessary to establish land rent on the basis of the market prices when the real value of land will be reflected instead of the normative, according to the third option - it is possible if there is market for agricultural land. The authors substantiate the problem of land valuation in its global and general economic measure, and, simultaneously, on the example of the Ukrainian practice, which proves the need to develop a sound methodology for fiscal regulation of agricultural land use, taking into account national specific.
DOES INNOVATION OUTCOME INFLUENCE PERFORMANCE OF INDIAN MANUFACTURING FIRMS?
Authors: Rath Badri Narayan , Bhattacahrya Poulomi
Published: March 2022

This paper investigates the impact of innovation on the performance of selected manufacturing firms in India over the period 2008-2017. Specifically, we emphasize on the role of innovation outcome in terms of number of patents on firms’ performance and consider total factor productivity growth, firms’ growth in terms of total gross sales, and profitability as indicators of firm performance. The results based on the panel Feasible Generalized Least Square estimator shows that the effect of innovation on firms’ performance is positive. Further, the impact of innovation on performance is higher for large firms compared to small firms.
THE ECONOMIC EFFECTS OF COVID-19 MITIGATION POLICIES ON UNEMPLOYMENT AND ECONOMIC POLICY UNCERTAINTY
Authors: Haldar Anasuya , Sethi Narayan
Published: March 2022

This paper examines the effects of government COVID-19 mitigation strategies and Economic Policy Uncertainty (EPU) on unemployment-rate over the period November 2019 to April 2021 for the 16 most severely COVID-19 affected countries. Our specific objectives are threefold: first, to examine the dynamic relationship between EPU and unemployment-rate; second, to analyze the extent to which government’s COVID-19 mitigation response affects the unemployment-rate; and third, to examine indirectly the effects of government economic policies on the unemployment-rate through market indicators, such as the business and consumer confidence indices. We find that EPU increases fluctuations in unemployment for the COVID-19 affected countries, while governments’ vaccination drive significantly reduces it. Increases in government stringency aggravate unemployment in the informal sectors and enhances labor inequality.
PANDEMICS, LOCKDOWN AND ECONOMIC GROWTH: A REGION-SPECIFIC PERSPECTIVE ON COVID-19
Authors: Dash Devi Prasad , Sethi Narayan
Published: March 2022

This study examines the impacts of COVID-19 induced factors and country specific health-care infrastructure and co-morbid factors on economic growth between January 1, 2021, to May 31, 2021 for 19 South and South-east Asian (SSEA) economies. Our findings indicate that COVID-19 related mortality negates growth, while vaccination and testing have no significant impact on growth during this period. We further quantify the effects by instrumenting government policy measures and vaccination drives in terms of testing, tracking and mortality. Our findings show a negative effect of lockdowns on growth, while vaccination has a positive impact on growth and controls fatality rate considerably.
Geochemical Evidence and Geological Prerequisites for Isochemical Metamorphism in the Kochumdek Contact Aureole (East Siberia)
Authors: Sokol E.V. , Kozmenko O.A , Deviatiiarova A.S. , Kokh S.N. , Polyansky O.P. , Philippova K.A.
Published: March 2022

—Marly limestone, marble, and gabbro–dolerite samples from the Kochumdek contact aureole are studied in order to estimate to which degree the spurrite–merwinite (T = 750–900 °C) metamorphism at the site was isochemical. The 3 m wide zoned Kochumdek aureole is located at the contact between the Early Triassic trap intrusion of the Kuzmovka complex (νβT1kz) and the overlying Llandovery marine marly limestones (S1ln) of the lower Kochumdek subformation in the right side of the Kochumdek River (tributary of the Podkamennaya Tunguska, East Siberia). The Kochumdek rocks are remarkable by the lack of prominent skarn or vein mineralization in marbles and autometasomatism in gabbro. The samples have been analyzed for major, chalcophile, rare-earth, and high-field strength elements. The Kochumdek marbles and marly limestones share similarity in major-element patterns that record mixing of fine siliciclastic material with biogenic and chemogenic CaCO3 components. The major-element chemistry of marly limestones has been controlled by the compositions of fine clastic material transported from the provenance (Trans-Angara part of the Yenisei Ridge) and by the deposition environment of the early Silurian marine basin. The contents of Cu, Ni, Co, V, Mo, Se, Cr, and U in marly limestones and marbles correspond to marine sediments deposited in a low-productive oxigenated environment. The Ni/Co, V/Cr, Cu/Zn, V/(V+Ni), and U/Th ratios in spurrite marbles at the intrusive contact remain within typical limestone ranges but differ from those in gabbro, which have higher V and Cu enrichment and moderate contents of Zn, Ni, and Co. Marly limestones and spurrite marbles show identical REE+Y patterns and average ΣREE contents. The major- and trace-element similarity between marbles and the protolith limestones, along with the absence of gabbro geochemical signatures in the metamorphic rocks, indicate that the thermal metamorphism was nearly isochemical. The reactions occurred without any large-scale transport of major and trace elements across the sill/sediment boundary. The conditions were unfavorable for metasomatic alteration due to low fluid saturation of the Kochumdek intrusion and its structural setting, as well as to the lithological, mechanical, and thermal properties of the sediments.
Microbial Translocation in Patients with Parkinson’s Disease in Zambia: a Case Control Study
Authors: Chishimba Lorraine , Sinkala Edford , Kelly Paul , Atadzhanov Masharip
Published: March 2022

BACKGROUND Over the past few years evidence has emerged that Parkinson’s disease (PD) could originate from the gastrointestinal tract. Gut leakiness in patients who are genetically susceptible to PD might be an important early component to initiation and progression of the disease, via microbial translocation mechanisms, but this has not been explored in Zambia. OBJECTIVESTo study the association of microbial translocation in patients with Parkinson’s disease (PD) in Zambia.METHODSWe conducted a case control study at the University Teaching Hospital in Lusaka Zambia between October 2019 and March 2020. We enrolled, consecutively 22 PD patients (20 previously diagnosed and 2 newly diagnosed) presenting to the neurology clinic and compared them to 44 unmatched controls from the PD patient household and non-household individuals. We measured plasma lipopolysaccharide binding protein (LBP) levels to assess systemic exposure to gut bacterial endotoxin lipopolysaccharide (LPS) and 16S ribosomal RNA (16S rRNA) gene copy number was quantified by quantitative real-time polymerase chain reaction. RESULTSUsing Fischer’s exact test there was no significant difference in the 16S rRNA gene copy number between the cases and controls (P-value: 0.122). In both groups the levels were very low to undetectable. Lipopolysaccharide binding protein levels were similar in both groups. CONCLUSIONThis data suggests that the markers of microbial translocation, 16S rRNA gene copy number and lipopolysaccharide binding protein levels, in Zambian patients with Parkinson’s disease are similar to those without Parkinson’s disease.