bluuebunny/crossref_metadata_2025 huggingface dataset:
A Two-stage Approach Using Artificial Neural Networks for Diagnosis of Heart Diseases Based on ECG Data
Authors:   Department of Industrial Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran., Mehrad Majid , Nojavan Majid ,   Department of Industrial Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran., Raissi Sedigh ,   Department of Industrial Engineering, Modeling and Optimization in Science and Engineering Research Center, Islamic Azad University, South Tehran Branch, Tehran, Iran., Javadi Mehrdad ,   Department of Mechanical Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran.
Published: May 2023

Background and Aim Most heart diseases show symptoms on ECG, but diagnosing heart disease with ECG requires the knowledge and experience of medical specialized. Because these specialists may not always be available, it is necessary to design tools to diagnose heart disease in these situations. In this paper, a two-stage approach based on artificial neural networks is designed to diagnose heart disease using ECG information.In this study, we aim to propose a two-stage approach using artificial neural network (ANN) to diagnose heart disease based ECG data. Methods & Materials To design the proposed approach, first the ECG data of 861 patients referred to medical centers in Arak, Iran were collected. The data were examined based on the opinions of specialists. Then, 154 features from ECG were used as inputs to the proposed model. In the first stage, an ANN was used to detect the ECG status (usable and unusable). In the second stage, using the usable ECG data, an ANN was used to diagnose the presence or absence of heart disease. Finally, the performance of the two-stage approach was evaluated and its accuracy and precision in determining the ECG quality and heart disease diagnosis were determined. Ethical Considerations This study was approved by the ethics committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1400.138). Results In the proposed approach, the ANN used for the determining the ECG status had a precision of 97.1% and an accuracy of 97.3%. The ANN used for the diagnosis of heart disease had a precision of 95.8% and an accuracy of 95.4%. Conclusion Considering the high efficiency of the proposed approach in determining of ECG status and diagnosing heart disease, it is possible to use this approach to help the treatment staff.
Effect of a Psychological Empowerment Program on Life Satisfaction and Attitudes Towards Aging in Older Women Living in Tehran, Iran
Authors:   Department of Counseling, Faculty of Humanities, Khomein Branch, Islamic Azad University, Khomein, Iran., Kermanshahi Fatemeh , Zare Bahramabadi Mehdi ,   Department of Counseling, Faculty of Humanities, Khomein Branch, Islamic Azad University, Khomein, Iran., Heidari Hasan ,   Department of Counseling, Faculty of Humanities, Khomein Branch, Islamic Azad University, Khomein, Iran., Davoodi Hossain ,   Department of Counseling, Faculty of Humanities, Khomein Branch, Islamic Azad University, Khomein, Iran.
Published: May 2023

Background and Aim Old age is a critical period in life. Due to advances in technologies and improvement in healthy conditions, the number of aged population is increasing. Hence, it is necessary to pay attention to their life satisfaction and attitudes towards aging. The present study aims to assess the effectiveness of a psychological empowerment program on life satisfaction and attitude towards aging in older women living in Tehran, Iran. Methods & Materials The study population consists of all women aged 60-70 years referred to a charity foundation in Tehran, Iran in 2020. Of these, 24 women were selected by a convenience sampling method. They were randomly assigned to the intervention (n=12) and control (n=12) groups. Using a pre-test/post-test design, the elderly first completed the life satisfaction index-Z and the attitude towards aging questionnaire. Then, the experimental group received the psychological empowerment program at 8 sessions. After the intervention, the questionnaires were completed again by both groups. Multivariate analysis of covariance was used to analyze the collected data in SPSS software, version 19. Ethical Considerations This study was approved by the Research Ethics Committee of Islamic Azad University of Arak Branch (Code: IR.IAU.ARAK.REC.1400.027). Results There was a significant difference in life satisfaction (F=9.673, P=0.006) and attitudes towards aging (F=8.385, P=0.009) between the two groups. The psychological empowerment program significantly improved life satisfaction and attitudes towards aging in older women. Conclusion The psychological empowerment program is effective in improving life satisfaction and attitude towards aging in older women living in Tehran. It can be used by experts in the fields of counseling, geriatrics, psychology, and health.
Structural Equation Modeling of Factors Related to Organizational Culture Involved in the Internationalization of Iranian Universities
Authors:   Department of Public Managemant, Rasht Branch, Islamic Azad University, Rasht, Iran., Heidari Mohammad Reza , Goudarzvand Chegini Mehrdad ,   Department of Public Managemant, Rasht Branch, Islamic Azad University, Rasht, Iran., Rezaei Kelidbari Hamid Reza ,   Department of Public Managemant, Rasht Branch, Islamic Azad University, Rasht, Iran., Rezaei Dizgah Morad ,   Department of Public Managemant, Rasht Branch, Islamic Azad University, Rasht, Iran.
Published: May 2023

Background and Aim The internationalization of higher education is an effective strategy to meet the diverse needs of a society. One of the factors determining the failure or success of internationalization is the organizational culture of universities. The present study aims to investigate the role of organizational culture-related factors in the internationalization of Iranian universities. Methods & Materials This is a quantitative-quantitative study. Participants were 124 Iranian experts in higher education and those involved in internationalization of universities. A researcher-made questionnaire was used as a self-report tool with close-ended questions. In the quantitative stage, structural equation modeling and first- and second-order factor analysis were performed in SPSS and AMOS software. Ethical Considerations This study was approved by the ethics committee of Islamic Azad University, Rasht Branch (Code: IR.IAU.RASHT.REC.1400.035) Results The ranking of factors affecting the internationalization of Iranian universities showed that the factor with the highest factor loading was “communication & interaction” (1.03) and the factor with the lowest factor loading was “human/physical/financial resources” (0.87). Conclusion Communication/interaction of universities with other education centers, as an organizational culture-related factor, plays an important role in the internationalization of Iranian universities.
The Effect of Core Stability Exercises on Pain and Inflammation of Patients With Piriformis Syndrome
Authors:   Department of Sport Pathology and Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran., Doosti Irani Rashid , Golpayegani Masoud ,   Department of Sport Pathology and Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran., Faraji Fardin ,   Department of Neurology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Published: May 2023

Background and Aim Sciatica is one of the most common diseases of the peripheral nervous system and may be caused by pressure on the sciatic nerve. Due to the fact that piriformis muscle located near the sciatic nerve, piriformis muscle spasm may put pressure on the nerve and cause sciatica and consequently piriformis syndrome. The present study aims to investigate the effect of core stability exercises on pain and inflammation of patients with piriformis syndrome. Methods & Materials This is a randomized clinical trial. The study population consists of all patients with piriformis syndrome referred to medical centers in Arak, Iran from. Of these, 20 were purposefully selected and randomly divided into two groups of control (n=10) and exercise (n=10). The exercise group performed core stability exercises for 6 weeks, while the control group continued their normal life during this period. To examine the differences between the study groups, t-test, Chi-Square test, and McNemar’s test were used. The significance level was set at 0.05. Ethical Considerations This study was approved by the Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1400.157) and was registered by Iranian Registry of Clinical Trials (ID: IRCT20211003052662N1). Informed consent was obtained from all participants. Results The Mean pain score in the control group decreased from 95.2 to 90.7 after the exercise, which was not statistically significant (P=0.562). In the exercise group, the mean pain score decreased from 91.7 to 33.4, and this decrease was statistically significant (P=0.0); Therefore, at 95% confidence interval, we can say that core stability exercises had a significant effect on the pain of patients with piriformis syndrome (P<0.05). The number of patients with inflamed nerve in the control group decreased from 10 in the pre-test phase to 8 in the post-test phase, but this decrease was not statistically significant (P=0.5). In the exercise group, it was reduced from 10 to 2, and this decrease was statistically significant (P=0.008); Therefore, we can say that core stability exercises had a significant effect on the inflammation of patients with piriformis syndrome (P<0.05). Conclusion Core stability exercises can reduce pain and inflammation in patients with piriformis syndrome. These exercises can be used in the treatment of these patients.
Cancer per Economic Activity at Brazil’s Southeast Region: Benefits Granted by the Brazilian Social Security System
Authors: Sales-Fonseca Nuria , Otero Ubirani Barros , Koifman Rosalina Jorge , Santos Sabrina da Silva
Published: May 2023

Introduction: Despite the economic importance of the Region, there are still few studies in the literature about occupational cancer in Brazil’s Southeast Region. Objective: Compare the distribution of cancer-related benefits granted by the Brazilian Social Security System (RGPS) by economic activity of the insured individual, between 2008 and 2014, at Brazil’s Southeast Region. Method: The proportions of cancer-related accidental (work-related) and social security (general) benefits granted, according to the economic activity of the insured individual (bank cashier, salesperson, transport and freight worker, railway worker, industrial worker, sailor, public servant, rural worker, and blank) were calculated. Results: Cancer represented 3.07% (271,086) of the benefits granted for all causes. Commercial and rural activities showed the largest proportions of cancer-related benefits granted in all States. For both activities, breast and prostate cancers were the main locations that justified the approval of social security benefits, and other malignant skin neoplasms were the main locations for accidental benefits. Conclusion: The disproportionality between the number of cancer-related social security and accidental benefits granted suggests an error in many benefits, disfavoring accidental benefits. The improvement of the anamneses of the worker by the medical expert, with the use of additional documents, can aid the establishment of the causal link between the professional activity and the cancer developed, granting accidental benefits when this link exists. Moreover, surveillance strategies to boost the implementation of actions to prevent occupational cancer are still necessary at that Region.
Evaluation of Performances of Calcined Laterite and Oyster Shell Powder Based Blended Geopolymer Binders
Authors: Ntom Nkotto Ludovic Ivan , Ntamag Lionel Jacques , Manjeh Ma-A Frances Jane , Sandjong Kanda Judicaël , Sontia Metekong Jordan Valdès
Published: May 2023

This work consisted in characterizing of calcined laterite and oyster shell powder based blended geopolymer binders. To do this, raw laterite taken from Soa in the city of Yaoundé and oyster shells extracted from Mouanko in the Sanaga-Maritime were initially air-dried, then dried at 105 °C, before being calcined at 500 °C and 200 °C respectively for 2 hours. These samples were subjected to preliminary studies, i.e. determination of their chemical and mineralogical compositions, particle size distributions, densities, as well as thermal analysis for the synthesis of geopolymer binders. X-ray diffractometry, thermal and gravimetric analysis were carried out on the oyster shell powder and laterite, in order to elucidate the time and degree of calcination of the two samples, the evolution of the linear shrinkage, the setting time as well as the compressive and flexural strengths of the geopolymer binders. The results obtained show that oyster shells are rich in CaCO3 and contain crystalline phases, while laterite is rich in silica, iron (FeCO3) and alumina (Al2O3). The geopolymer samples: Lat + 0% oyster shells have a setting time between 125 and 168 min for a compressive strength of about 47 MPa. The peak strength is observed around 15% addition of oyster shell powder, i.e. 53.5 MPa at 28 days with an increased setting time. This strength was decreased from 25 % of addition of oyster shells, despite the increase observed in the setting time. It appears from this study that the addition of 15% oyster shell increases the compressive strength of the geopolymer, but also leads to a considerable decrease in absorption rate. Above this rate, the compressive strength decreases drastically and concomitantly the setting time increases.
LEVEL OF KNOWLEDGE OF EARLY DETECTION OF BREAST CANCER IN USU FACULTY OF MEDICINE STUDENTS 2018-2019
Authors: Nadira Afia  , Denny Rifsal Siregar
Published: May 2023

Introduction. Breast cancer is a malignant tumor that grows in breast tissue can come from components such as fat tissue, blood vessels. Early detection is one of the breast cancer prevention efforts that can help reduce the incidence of breast cancer. There are three ways to prevent breast cancer including primary prevention, secondary prevention and tertiary preventionMethod. This study uses a descriptive type of research with a cross-sectional approach. The population in this study amounted to 495 students and the sample to be carried out in this study was 83 students of the Faculty of Medicine, University of North Sumatra 2018-2019 who met the inclusion criteria. Data analysis used univariate analysis with frequency distribution table.Results. The level of knowledge of USU Faculty of Medicine 2018-2019 students was 61.5% good, 38.5% sufficient, and there were no students who had a low level of knowledge..Keywords: Level of Knowledge. Early detection. Breast cancer
ASSOCIATION BETWEEN SERUM ALP LEVELS AND PRE-OPERATIVE LDH TOWARDS CLINICAL PROGNOSIS OF OSTEOSARCOMA PATIENTS IN H. ADAM MALIK HOSPITAL, MEDAN
Authors: Gerhard Christoffel Tampubolon  , Otman Siregar  , Andriandi
Published: May 2023

Background: The prognosis of osteosarcoma is very unsatisfactory due to frequent tumor metastases to the lung or resistance to chemotherapy. A marker is needed to identify the prognosis of patients with osteosarcoma when diagnosed with the aim of being able to receive cancer treatment as soon as possible to improve a better prognosis. Alkaline phosphatase (ALP) and Lactate dehydrogenase (LDH) have potential in assessing the prognosis in osteosarcoma.

Purpose and Objectives: The researcher wanted to investigate the relationship between preoperative serum ALP and LDH levels on the clinical prognosis of osteosarcoma patients.

Methods: This research is analytic retrospective with the source of data is medical records and was conducted at the Department of Surgery FK-USU/RSUP Haji Adam Malik Medan with research code of ethics No. 426/KEPK/USU/2022. The subjects of this study were patients with osteosarcoma who were treated at Division of Orthopedic Surgery at Haji Adam Malik Hospital Medan from January 2015-December 2017 who met the inclusion criteria.

Results: There was no significant relationship between ALP and LDH with five-year survival with p-values ​​of 0.557 and 0.179 (p>0.05). ALP has a weak correlation with five-year survival with an r value of -0.019 which means the higher the ALP, the lower the five-year survival of the patient. Meanwhile, LDH has a weak correlation with an r value of 0.093, which means the higher the LDH, the higher the patient's five-year survival. The ALP value in this study had a median value of 212 U/L and an LDH value of 489 U/L. ALP has sensitivity of 61.1% and specificity of 57.1% with a cut-off of 217.5 U/L. Meanwhile, LDH sensitivity was 61.2% and specificity was 51.4% with a cut-off of 488.5 U/L.

Conclusion: There is no significant relationship between ALP and LDH with five-year survival.
CLINICOPATHOLOGICAL CHARACTERISTICS OF INVASIVE BREAST CARCINOMA ON PDL-1 IMMUNOHISTOCHEMICAL EXPRESSION IN H. ADAM MALIK HOSPITAL MEDAN
Authors: Lesmana Daniel Kristian Prawira , Denny Rifsal Siregar  , Dedy Hermansyah
Published: May 2023

Abstract

Background: Immune biologic markers that can predict clinical response to anti-PD-1/PD-L1 therapy are needed to identify and validate tumor immunotherapy studies. High PD-L1 expression is associated with increased clinical response in patients with various types of cancer treated with inhibitors of the PD-1/PD-L1 pathway. The researcher wanted to see the clinicopathological characteristics of invasive breast carcinoma according to the immunohistochemical expression of PD-L1.

Methods: This study is a descriptive study with a cross-sectional, retrospective approach by looking at secondary data from the medical records of the Department of Surgery, Oncology Division, Haji Adam Malik Hospital from January 1, 2019, to December 31, 2021.

Results: Immunohistochemical expression of PD-L1 was positive in 76.6% of invasive breast carcinomas and negative in 23.3% of invasive breast carcinomas. Immunohistochemical expression of PD-L1 was positive in non-specific IBCs that predominated in every molecular subgroup of breast carcinoma.

Discussion: Tumours can show positive or negative PD-L1 expression through several biological processes with different functional significance, namely the genetic mechanism of constitutive or oncogene-induced PD-L1 expression, PD-L1 expression induced in T cells, and absence of PD-L1 expression. Due to the absence of T cells and genetic events that block the expression of PD-L1 despite T cell infiltration.
Correlation Between Pregnant Women’s Anxiety Level and Their Decision Towards COVID-19 Vaccine Acceptance
Authors: Panjaitan Kyrie Hanna
Published: May 2023

Background. High number of COVID-19 cases cause various effects, namely increased anxiety and depression in pregnant women, who are susceptible to transmission. To prevent further transmission, a vaccination policy was implemented which then elicited various responses. Low percentage of pregnant women’s willingness to be vaccinated was found. This happened because of anxiety and hesitancy towards COVID-19 vaccine among them. Aim. Knowing the correlation between the level of anxiety in pregnant women towards COVID-19 vaccine and the decision to accept COVID-19 vaccine at Abadijaya Public Health Center, Depok. Method. Analytic with cross sectional method is used. Population and sample of this study were 96 pregnant women who visited Abadijaya Public Health Center, Depok. Results. Analysis conducted using chi square and fisher exact test shows majority of pregnant women do not experience symptoms of anxiety (50%), no correlation between age, gestational age, gravidity, occupation and education level on the decision to accept COVID-19 vaccine, and correlation between pregnant women’s anxiety levels and the decision to accept COVID-19 vaccine was found (p value = 0.000). Conclusion. There is a correlation between anxiety levels in pregnant women towards COVID-19 vaccine and the decision to accept COVID-19 vaccine at Abadijaya Public Health Center, Depok.
Prevalence and Correlated Factors of Urinary Incontinence in Geriatic
Authors: Purba Adriel John Junior
Published: May 2023

Abstract. Background. Urinary incontinence is involuntary or uncontrollable urine passing. This is very disruptive, it causes a lot of problems and is often seen as an embarrassing thing. The prevalence of urinary incontinence was found to increase with age. The number in the geriatric population is 22.2%, more significant when compared to the adult population of 12.0%. Objectives. This research aimed to determine the prevalence and factors associated with the incidence of urinary incontinence in geriatric patients at the Haji Adam Malik General Central Hospital and the University of North Sumatra Hospital. Method. This type of research is an analytic observational study with a cross-sectional design. The research sample is determined by consecutive sampling technique using a questionnaire as primary data. Results. Out of 100 respondents, 22 geriatric patients experienced urinary incontinence, with the majority experiencing moderate severity and stress urinary incontinence. Based on bivariate analysis using chi-square found gender (p=0.617), age (p=0.617), overweight (p=<0.001), diabetes mellitus (p=<0.001), hypertension (p=0.001), history of chronic cough (p=<0.001), history of pelvic surgery (p=<0.001), and history of vaginal delivery (0=0.055). Conclusion. There are 22% (22 patients) of geriatric patients experienced urinary incontinence. In this study, the risk factors associated with urinary incontinence are overweight, diabetes mellitus, hypertension, and a history of chronic cough while risk factors that are not found to be associated in this study are age, sex, and history of vaginal delivery.
DIETS THAT HAVE POTENTIAL TO STIMULATE THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS IN SPRAGUE DAWLEY RATS
Authors: Khairil Azwan  , Muhammad Noorzaid
Published: May 2023

The pituitary gland is the master gland which regulates the body hormones. From the corticotrophs of the anterior pituitary gland, adrenocorticotrophic hormone (ACTH) is secreted and influences corticosterone production in rodents via the hypothalamic–pituitary–adrenal axis (HPA axis). ACTH and corticosterone are frequently used as a hormonal marker of stress level. Disturbance in ACTH and corticosterone were observed in many diseases especially Addison’s disease, Cushing’s syndrome, and metabolic syndrome. Our objective is to observe which diet produces the most and least stress to the Sprague Dawley rat’s physiology. Method: Thirty-five Sprague Dawley rats were grouped into five groups (n=7) and were given five different types of diets (control, high-fat, high-protein, high-sugar, and high-starch) with tap water supplied as drinking water ad libitum. By the end of eight weeks, the rat’s blood was collected, and serum separated. The individual components of ACTH and corticosterone from the blood was extracted, purified, identified, and quantified using the High-Performance Liquid Chromatography (HPLC) with photodiode array (PDA) analysis method. Result: The analytical studies revealed a high -sugar diet registered highest ACTH blood level. It was also revealed that the high-fat and high-sugar diet group presented with the highest peak for corticosterone. Conclusion: Consumption of high-fat and high-sugar diet for eight weeks is suggested to induce physiologic and metabolic stress in Sprague Dawley rats as evidenced by the HPA activation.
Analisi quantitativa ed epidemiologica dei casi di morbillo a Macapá-AP dal 2017 al 2021
Authors: Mendes Fabrízio do Amaral , Rodrigues Rafael Henrique de Andrade , Souza Yngrid Sheron Ribeiro de , Rodrigues Gabriel Vinícius de Andrade , Dias Claudio Alberto Gellis de Mattos , Dendasck Carla Viana , Oliveira Euzébio de , Fecury Amanda Alves
Published: May 2023

Obiettivo: Analizzare epidemiologicamente i casi di morbillo a Macapá dal 2017 al 2021, considerando i loro aspetti sociodemografici e clinici. Metodo: è stato condotto uno studio descrittivo con un approccio quantitativo e l’analisi dei dati secondari. La popolazione era composta da tutte le notifiche con morbillo sospetto o confermato nelle Unità Sanitarie di Macapá attraverso i moduli obbligatori di notifica del morbillo e della rosolia. Risultato: 788 casi sospetti sono stati registrati a Macapá, con 576 casi confermati nel periodo valutato. L’anno 2021 è stato predominante nei casi con n=407 (71%) notifiche confermate. Dimostra anche il profilo dei casi segnalati, in maggioranza bambini, con una leggera predilezione per i maschi, provenienti principalmente dall’area urbana. Conclusione: i dati indicano una crescita esponenziale del morbillo nel comune studiato e la copertura vaccinale e le politiche sanitarie nell’assistenza primaria dovrebbero essere incoraggiate e rafforzate.
Artificial Intelligence and Accounting Education: Focusing on ChatGPT and Its Applications
Authors:   Korean Association Of Computers And Accounting, Yoon Yang－In
Published: May 2023

Artificial Intelligence has a significant impact on every aspect of our daily life and every industry. The recent introduction of ChatGPT accelerated these changes. This study examines the performance of ChatGPT on accounting cases and its implications for accounting education. ChatGPT generates correct answers and explanations for illustrating the core concepts of accounting and posting the journal entries upon the relatively simple transactions. However, ChatGPT has limited capacities on processing more complicated events and transactions. In accounting education, it becomes more important to evaluate student work more accurately particularly when the students submit the incomplete works that are easily accessible through ChatGPT. The further discussion and correction process over the incorrect parts can also be key processes for accounting education.
EFFECT OF NEOCARYA MACROPHYLLA LEAVES EXTRACTS ON MURINE MODEL OF PAIN
Authors: Bature Hafsatu Buhari , Tsafe A. I. , Zauro S. A. , Yusuf A. J.
Published: May 2023

Pain is the most common symptom of disease, which accompanies us from an early age. It is connected to the stimulus that it invokes and is also based on the observation of psychological interpretation of the phenomena taking place. The aim of this research is evaluation of the effect of Neocarya macrophylla leaves extracts on animal model of Pain. The pulverized leaves were extracted by maceration using 90 % methanol for 7 days and filtered to retrieve the residue known as the crude methanol leaf extract (MEL). Some part of MEL (60 g) was partitioned into fractions of different solvents with increasing polarity including chloroform (CF), ethylacetate (EF), n-butanol (BF) using liquid-liquid fractionation. Acute toxicity study was carried out to determine the LD50 of CF and it was estimated to be 565 mg/kg using Lorke’s method. Analgesic studies was carried out on extract and partitioned fractions using acetic acid-induced writhing test in mice and the results revealed that the extract and fractions of the plant has significant (p<0.05) analgesic effect with EF being the most active fraction and CF being the least active; EF demonstrated significant (p<0.05) and dose-dependent analgesic activity with 83.9, 82.5 and 73.4 % inhibition of writhes at 20, 40 and 80 mg/kg, respectively; the standard drug, piroxicam (at 10 mg/kg) had 96.5 % inhibition of writhes. Qualitative phytochemical screening on the fractions revealed the presence of some phytochemicals.Conclusively, this study indicates that the leaves of N. macrophylla contains phytochemical constituents with analgesic
Adenosine signaling inhibits erythropoiesis and promotes myeloid differentiation
Authors: Mikdar Mahmoud , Serra Marion , Colin Elia , Duval Romain , Gauthier Emilie-Fleur , Lamarre Yann , Colin Yves , Le Van Kim Caroline , Peyrard Thierry , Koehl Bérengère , Azouzi Slim
Published: May 2023

Intracellular uptake of adenosine is essential for optimal erythroid commitment and differentiation of hematopoietic progenitor cells. The role of adenosine signaling is well documented in the regulation of blood flow, cell proliferation, apoptosis, and stem cell regeneration. However, the role of adenosine signaling in hematopoiesis remains unclear. In this study we show that adenosine signaling inhibits the proliferation of erythroid precursors by activating the p53 pathway and hampers the terminal erythroid maturation. Furthermore, we demonstrate that the activation of specific adenosine receptors promotes myelopoiesis. Overall, our findings indicate that extracellular adenosine could be a new actor in the regulation of hematopoiesis.
The Comparative Study of Epidural Levobupivacaine and Bupivacaine in Major Abdominal Surgeries in Type- 2 Diabetic Patient
Authors: Shaheen Md Shafiul Alam , Rahman Md Khalilur , Sardar Kawsar , Hasan Md Mahabubul , Rahman Md Mushfiqur , Chowdhury AKM Nurnobi , Ahmed Raju
Published: May 2023

Background: Major abdominal surgeries still induce neurohumoral changes responsible for postoperative pain, various organ dysfunctions, prolong hospitalization and convalescence. Insufficient pain therapy prolongs the hospital stay and rises the mortality rates. Epidural analgesia confers excellent pain relief and complete dynamic analgesia leading to a substantial reduction in the surgical stress response. Opioid and local anaesthetic infusion by an epidural catheter is widely used as a postoperative pain management method after major abdominal surgeries. Type-2 Diabetic patient has many comorbidity with cardiovascular complication and they are more vulnerable to pain.
Objectives: The purpose of this study was to compare the effect of levobupivacaine and bupivacaine with fentanyl in postoperative analgesia and haemodynamic changes of type-2 Diabetic patients for major abdominal surgeries.
Material and method: Sixty (60) patients were selected whose were suffering from Type-2 Diabetes mellitus and were going to be operated for major abdominal surgeries (Whipple’s procedure, FCPD, Gastrectomy, Hemi colectomy). Every patient received an epidural block in the sitting position at the T8- 9 or T9-10 level via 18 G Touhy needle. Each patient in group A received 0.125% levobupivacaine with 2 μgm. fentanyl / ml solution through epidural catheter @ 4 ml / hr. and group B were received 0.125% bupivacaine with 2 μgm. fentanyl / ml solution through epidural catheter@ 4 ml / hr
Results: Mean visual analog scale (VAS) values of groups did not differ at all time. They were 6 at the end of the surgery (0.Min, p= 0.06). The VAS scores were not statistically significant in group A & group B (p > 0.05). The frequency of tachycardia was higher in group B that was bupivacaine group.
Conclusion: The results of our study suggest same concentration of epidural levobupivacaine and bupivacaine with fentanyl provide stable postoperative analgesia and both were found safe for the patients undergoing major abdominal surgery, but levobupivacaine is less tachycardic and safer for Type-2 Diabetic patient.
JBSA 2017; 30(1): 5-13
Management of a Patient with Sudden Onset of Intra Operative Atrial Fibrillation Posted for Emergency Evacuation of Clot Following TURP Operation Under SAB
Authors: Das Debashish , Mahmood Wahiuddin , Ali SM , Das Basudeb , Khan Ayub
Published: May 2023

Atrial fibrillation is very common cardiac arrythmia which is encountered during the perioperative period. Atrial fibrillation in perioperative period may lead to hemodynamic impairment and thromboembolic events resulting into significant morbidity and mortality. So it is very crucial for an anesthesiologist to maintain the hemodynamic stability of the patient with atrial fibrillation and prevent furthur complications associated with it. Here we report a case of sixty year old male patient posted for emergency evacuation of clot following TURP operation.
JBSA 2017; 30(1): 48-50
Efek ukuran sampel pada parameter GRM yang didasarkan pada korelasi inter item
Authors: Susanto Hari Purnomo , Retnawati Heri , Setiawati Farida Agus
Published: May 2023

Teori respon butir memiliki banyak kelebihan Ketika digunakan untuk menentukan karateristik butir instrumen jika ukuran sampel yang digunakan besar. Sebaliknya, jika ukuran sampel kecil IRT memiliki kecenderunga kurang akurat dalam menentukan karakteristik suatu instrumen. Penelitian ini bertujuan untuk menentukan efek ukuran sampel pada GRM yang didasarkan pada data awal yang memiliki korelasi inter item yang sama secara statistik. Penelitian ini merupakan penelitian simulasi yang didasarkan pada data empiris. Data skunder dari 43 responden digunakan sebagai data awal. Akurasi efek dari ukuran sampel baru dihitung dengan menggunakn RMSE dan koelasi. Teknik membangkitkan data yang digunakan yaitu metode multivariat variabel random diskrit. perangkat lunak R. Hasil penelitian menunjukkan nilai RMSE berkisar 0,6 > 0,33 dan korelasi sekitar 0,5 < 0,7 tidak memenuhi standar akurasi.. Dapat disimpulkan bahwa ukuran sampel dengan matriks korelsi yang sama, tidak memiliki efek pada parameter GRM dan data baru yang dihasilkan tidak dapat digunakan untuk pemulihan parameter GRMÂ The effect of sample size on GRM parameters based on the correlation between itemsÂ Abstract: Item response theory has many advantages in determining the instrument's item characteristics when the sample size used is large. On the other hand, if the sample size is small, the IRT tends to be less accurate in determining an instrument. This study aims to determine the effect of sample size on GRM based on the inter-item correlation matrix of initial data. This research was conducted on simulation research based on empirical data. Secondary data from 43 respondents was used as initial data. The effect accuracy of the new sample size was calculated using RMSE and correlation. The data generation method used was the multivariate method of discrete random variables. The results show that the RMSE value is around 0.6 > 0.33, and the correlation of about 0.5 < 0.7 did not meet the standard of accuracy. It could be concluded that the sample size with the same inter-item correlation matrix has no effect on the GRM parameters, and the new data generated couldnâ€™t be used for GRM parameter recovery.
Comparison of Surgical Outcomes between Conventional Sutured Scleral Fixation and Flanged Intrascleral Intraocular Lens Fixation
Authors: Jo Gwon Hui , Seo Eoi Jong , Jung Moon Sun , Kim Kyung Tae
Published: May 2023

Purpose: We compared the surgical outcomes and complications of conventional, sutured scleral fixation and flanged intrascleral intraocular lens (IOL) fixation.Methods: We retrospectively analyzed the medical records of patients who underwent conventional, sutured scleral fixation or flanged intrascleral IOL fixation and who were then observed for more than 6 months. The best-corrected visual acuity (BCVA), operation time, spherical equivalent (SEQ), astigmatism, and postoperative complications were recorded up to 6 months after surgery.Results: Of sixty-nine enrolled eyes, 39 underwent conventional, sutured scleral fixation (“sutured” group) and 30 flanged intrascleral IOL fixation (“sutureless” group). The operation time was significantly shorter in the sutureless group than in the sutured group (56.3 ± 11.8 vs. 77.7 ± 17.9 minutes, p < 0.001). In both groups, the BCVA and SEQ improved significantly at all visits after surgery compared to the baseline values p < 0.05). There was no between-group difference in BCVA, SEQ, astigmatism, or complications.Conclusions: Compared to conventional, sutured scleral fixation, flanged intrascleral IOL fixation afforded equivalent improvements in visual acuity but with a shorter surgical duration. Therefore, flanged intrascleral IOL fixation is a useful alternative to conventional, sutured scleral fixation.
Comparison of Short-term Clinical Outcomes between Sutured Scleral Fixation and Modified Yamane Sutureless Scleral Fixation
Authors: Kim Tae Hwan , Kwon Yoon Hyung
Published: May 2023

Purpose: To compare and investigate the short-term clinical outcomes between 10-0 polypropylene sutured intraocular lens (IOL) scleral fixation and modified Yamane sutureless IOL scleral fixation in patients with IOL or crystalline les dislocation and aphakic state.Methods: From August 2012 to May 2022, medical records were retrospectively analyzed for 43 patients with sutured scleral fixation and 40 patients with sutureless scleral fixation. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), total astigmatism, IOL astigmatism, refractive error, corneal endothelial cell density, surgical time and complications were compared before surgery, 1 week, 1 month, and 3 months after surgery.Results: In the two groups, after 3 months of surgery, UCVA and BCVA improved compared to before surgery, but there was no significant difference between two groups. The absolute refractive error and total astigmatism for one week after surgery and IOL astigmatism for one week and one month after surgery were significantly lower in sutureless fixation group. There was no significant difference in postoperative corneal endothelial cell density changes between two groups, and total surgical time and IOL fixation time were measured significantly lower in sutureless fixation group.Conclusions: Although modified Yamane sutureless IOL scleral fixation did not show significant improvement in visual acuity compared with conventional sutured IOL scleral fixation, sutureless fixation provided better stability of IOL in the early stages after surgery and short in the surgical time. So it can be an effective alternative to conventional sutured scleral fixation in patients with IOL or crystalline lens dislocation and aphakic state.
Incidence and Time of Onset of Retinopathy in Premature Infants in Korea
Authors: Kim Min Seong , Cho In Hwan , Kim So Young
Published: May 2023

Purpose: This study examined the incidence and time of onset of retinopathy in premature infants in Korea.Methods: The medical records of premature infants admitted to the neonatal intensive care unit from 2006 to 2018 were reviewed retrospectively. Stages 1 and 2 were classified as mild retinopathy and stages 3 and 4 were considered severe. The incidence, severity, time of diagnosis, associations between retinopathy and birth weight and also gestational age, and clinical characteristics of the treated infants were analyzed.Results: The incidence of retinopathy was 10.9% with an average time of diagnosis at 34.92 weeks postmenstrual age; the frequency of severe retinopathy was 44.97%. Birth weight and gestational age were significantly lower in premature infants with retinopathy than in normal infants. In addition, birth weight was significantly lower in those with severe retinopathy than in those with mild retinopathy. For birth weight and gestational age, the incidence and severity of retinopathy tended to be higher in those with birth weights less than 1,000 g and gestational ages of less than 27 weeks. Of the infants, 4.51% underwent laser photocoagulation; the times of diagnosis, progression to type 1 retinopathy, and treatment were 33.75, 35.06, and 36.04 weeks postmenstrual age, respectively.Conclusions: The incidence and severity of retinopathy of premature infants increased in those with birth weights less than 1,000 g and gestational ages less than 27 weeks. Such infants should be monitored carefully between 32 to 36 weeks of postmenstrual age, when retinopathy is mainly diagnosed.
Long-term Outcome of Anterior Chamber Parameters after Laser Iridotomy and Iridoplasty in Primary Angle Closure Glaucoma
Authors: Park Se Ik , Lee Woo Hyuk , Kang Tae Seen , Kim Ji Hye , Han Yong Seop , Cho Hyun Kyung
Published: May 2023

Purpose: To investigate the long-term outcomes of anterior chamber angle parameters in patients with primary angle closure glaucoma (PACG) after peripheral laser iridotomy (LI) combined with iridoplasty (PI) using a dual Scheimpflug analyzer.Methods: This retrospective study included 32 eyes in 32 patients diagnosed with PACG who underwent LI plus PI. Patients with an acute angle closure crisis were excluded. Dual Scheimpflug analyzer images were acquired before and 1 week after LI plus PI, and yearly afterwards. Anterior chamber depth (ACD) and volume (ACV), mean anterior chamber angle (ACA), and intraocular pressure (IOP) were also measured.Results: The mean follow-up was 32.28 ± 13.34 months. Baseline demographics were age 63 ± 7.9 years, 62.5% female, IOP 15.48 ± 4.79 mmHg, ACD 2.09 ± 0.19 mm, and visual field mean deviation -7.97 ± 8.49 dB. ACD increased from baseline to 2.15 ± 0.32 mm, but it was not significant (p = 0.136). ACV increased significantly from 78.32 ± 11.49 mm at baseline to 83.04 ± 11.16 mm at the last visit after LI (p = 0.011). The mean ACA increased significantly from 26.86 ± 2.53° at baseline to 28.82 ± 4.64° at the last visit (p = 0.022). IOP decreased significantly from baseline to 13.06 ± 2.21 mmHg at the last visit (p = 0.001).Conclusions: The ACA parameters improved after LI combined with PI in patients with PACG and remained so on long-term follow-up. IOP was also significantly reduced for more than 2.5 years after LI plus PI.
A Case of a Patient with Refractory Scleritis Treated with Rituximab
Authors: An Jeong Hyun , Song Myung-Sun , Kim Dong Hyun
Published: May 2023

Purpose: We report a patient with refractory scleritis effectively treated with rituximab after ineffective, initial, conventional immunosuppressive therapy.Case summary: A 58-year-old woman with no specific medical history presented with recurrent scleritis of the right eye. Her uncorrected visual acuities in both eyes were 20/20, and a blood test for cytoplasmic antineutrophil cytoplasmic antibody (C-ANCA) was positive. Systemic and subconjunctival steroid treatments were not effective, and the scleritis recurred even after further treatment with oral cyclosporin A and mycophenolate mofetil. After intravenous administration of infliximab (5 mg/kg), slight improvement was noted, but the recurrence continued. Thereafter, the visual acuity of the right eye decreased markedly because of choroidal and serous retinal detachment caused by posterior scleritis. Immunohistochemically, the inflamed scleral tissue showed considerable B-cell infiltration. Accordingly, intravenous rituximab (1 g) was administered twice at a 2-week interval. The scleral vessel engorgement and inflammation dramatically improved, and the scleritis became well-controlled without recurrence for more than 8 months.Conclusions: Intravenous rituximab may be helpful when encountering scleritis refractory to conventional immunomodulation therapy.
Pengembangan Kurikulum Berbasis Kebutuhan Peserta Didik dan Kehidupan Global dalam Konteks Indonesia
Authors: Bachtiar Bachtiar
Published: May 2023

Artikel ini bertujuan untuk mendiskusikan pengembangan kurikulum berbasis kebutuhan peserta didik dan kehidupan global dalam konteks Indonesia. Salah satu aspek penting yang berkaitan dengan pelaksanaan pendidikan adalah pengembangan kurikulum. Kurikulum sebagai perangkat perencanaan dan sistem tentang tujuan, isi, materi dan metode yang digunakan pada proses belajar dan mengajar untuk mencapai tujuan pendidikan mempunyai peran penting dalam pendidikan nasional. Kurikulum sebagai komponen pendidikan bersifat dinamis, selalu berubah seiring dengan waktu. Perubahan itu sangat penting seiring dengan perubahan masyarakat, kebutuhan siswa, dan perkembangan ilmu dan teknologi. Perkembangan kurikulum pendidikan di Indonesia telah mengalami perubahan berkali-kali. Perubahan tersebut disusun dan dikembangkan sesuai kebutuhan siswa, sekolah, dan masyarakat.
Persepsi Mahasiswa Tentang Online Learning Pada Mata Kuliah Ilmu Kealaman Dasar Prodi Pendidikan Bimbingan dan Konseling IKIP Gunungsitoli
Authors: Laoli Jonisman Kristian
Published: May 2023

Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa Program Studi Bimbingan dan Konseling terhadap mata kuliah Ilmu Kealaman Dasar yang di tinjau berdasarkan lima aspek. Sampel dalam penelitian ini adalah Mahasiswa Prodi Bimbingan dan Konseling di IKIP Gunungsitoli yang mengontrak matakuliah Ilmu Kealaman Dasar sebanyak 36 orang. Jenis Penelitian ini adalah penelitian deskriptif kualitatif. Sumber primer didapatkan dari kuesioner yang diberikan kepada mahasiswa pendidikan Bimbingan dan Konseling yang mengontrak matakuliah Ilmu Kealaman Dasar (IKD). Hasil penelitian diperoleh bahwa mahasiswa merasa puas atau memiliki persepsi yang positif terhadap pembelajaran daring, mahasiswa merasa puas terhadap variasi metode pembelajaran yang digunakan dosen selama daring, mahasiswa mampu menguasai dan menggunakan teknologi dalam perkuliahan, mahasiswa memiliki motivasi yang baik dalam perkuliahan dan mahasiswa mampu menyerap materi pembelajaran dengan baik.
Penerapan Pendidikan Karakter Melalui Pendidikan Agama Islam di Masa Pandemi Covid-19; Studi Kasus SMP IT Harapan Umat Karawang
Authors: Samsiah Silvi , Nurlaili Acep , Suryana Sayan
Published: May 2023

Pandemi Covid-19 yang terjadi belakangan ini sangat mempengaruhi banyak aspek, salah satunya aspek pendidikan. Proses belajar mengajar harus tetap berlangsung dengan semestinya agar seluruh peserta didik bisa mendapatkan layanan pendidikan yang optimal namun tetap mengutamakan protokol kesehatan guna memutus rantai penyebaran Covid-19 semaksimal mungkin. Kondisi ini membuat proses pembelajaran yang semula bersifat tatap muka di kelas harus bertransformasi menjadi pembelajaran daring. Sistem pembelajaran yang berbeda ini membuat pelaksanaan penerapan pendidikan karakter terhambat. Penelitian ini berusaha mengungkap bagaimana SMPIT Harapan Umat menerapkan pendidikan karakter di masa pandemi Covid-19. Pengumpulan data dilakukan melalui observasi di mana peneliti terjun langsung ke lapangan untuk mengamati proses pembelajaran jarak jauh, serta dokumentasi yang diperoleh dari kegiatan pembelajaran selama pandemi. Data yang diperoleh kemudian dianalisis melalui tiga tahapan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Adapun hasil penelitian ini yaitu: Kegiatan belajar secara online yang dilakukan dengan desain seperti pembelajaran tatap muka. menerapkan budaya sekolah yang biasa dikerjakan di sekolah. Menjalin kerjasa sama antara guru dan orang tua siswa.
Penerapan Model Pembelajaran Group Investigation Berbantuan Modul Pada Mata Kuliah Praktek Kayu
Authors: Telaumbanua Aprianus , Dakhi Oskah , Zagoto Maria Magdalena
Published: May 2023

Penelitian ini bertujuan untuk meningkatkan interaksi sosial dan prestasi belajar mahasiswa pada Prodi Pendidikan Teknik Bangunan pada mata kuliah Praktek Kayu dengan menggunakan model pembelajaran Group Investigation berbantuan Modul. Penelitian ini merupakan Penelitian Tindakan Kelas yang dilaksanakan dalam dua siklus, setiap siklus terdiri dari perencanaan tindakan, pelaksanaan tindakan, observasi, dan refleksi. Subjek penelitian adalah mahasiswa Prodi Pendidikan Teknik Bangunan, Semester II Tahun Akademik 2019/2020. Subyek penelitian ini adalah 25 mahasiswa Pendidikan Teknik Bangunan yang sedang mengikuti mata kuliah Konstruksi Bangunan. Sumber data berasal dari dosen dan mahasiswa. Data diperoleh melalui angket, tes, observasi, wawancara, dan kajian dokumen. Teknik analisis data yang digunakan adalah analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa penerapan model pembelajaran Group Investigation berbantuan Modul dapat meningkatkan interaksi sosial mahasiswa pada mata kuliah Pratek Kayu Semester II Tahun Akademik 2019/2020 dengan persentase ketercapaian interaksi sosial mahasiswa pada siklus I sebesar 75,25% menjadi 82,70% pada siklus II. Prestasi belajar mahasiswa aspek kognitif mengalami peningkatan pada siklus I sebesar 52% menjadi 76% pada siklus II, sedangkan prestasi belajar aspek afektif mengalami peningkatan sebesar 77,93% pada siklus I menjadi 83,88% pada siklus II.