bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunological Parameters in Patients Suffering from Atopic Dermatitis and Either Treated or Non-Treated with Dupilumab
Authors: Boudková Petra , Čelakovská Jarmila , Čermáková Eva , Andrýs Ctirad , Krejsek Jan
Published: November 2023

Objective: The aim of the study is to analyze the absolute count of leukocytes, neutrophils, monocytes, eosinophils, T cells, natural killer cells, B cells and to evaluate the expression of functionally important CD23 and CD200 molecules on B cells in patients suffering from atopic dermatitis (AD), (with and without dupilumab therapy). Materials and Methods: We examined 45 patients suffering from AD – 32 patients without dupilumab treatment (10 men, 22 women, average age 35.0 years), 13 patients with dupilumab treatment (7 men, 6 women, average age 43.4 years) and 30 healthy control (10 men, 20 women, average age 44.7 years). Immunophenotype was examined by flow cytometry (Navios Flow Cytometer – Beckman Coulter). The blood count was examined with a Sysmex XN 3000, Sysmex SP10, microscope DI60 for digital morphology evaluating cell division and microscope Olympus BX40. We compared the absolute count of leukocytes and their subsets, T cells (CD4, CD8), natural killers cells, absolute and relative count of B lymphocytes and expression of surface molecules CD23 and CD200 on B cells in AD patients and in control group. Non-parametric Kruskal-Wallis one-factor analysis of variance with post-hoc (follow-up multiple comparison) and Dunn’s test with Bonferroni modification of significance level were used for statistical analysis. Results: We confirmed the significantly higher number of neutrophils, monocytes and eosinophils and higher expression of CD23 and CD200 on B cells in peripheral blood of AD patients (either with or without dupilumab) therapy. We demonstrated the lower number of CD8+ T cells. Conclusion: We demonstrated the difference in the count of white blood cells populations in patients suffering from AD compared with healthy control. There were a differences in the expression of immunoregulatory molecules CD23 and CD200 on B cells in AD patients (either with or without dupilumab therapy) in comparison to healthy controls.
Parkinson’s Disease, Impulsive-Compulsive Behaviors, and Health-Related Quality of Life
Authors: Grall-Bronnec Marie , Verholleman Audrey , Victorri-Vigneau Caroline , Leboucher Juliette , Thiabaud Elsa , Hardouin Jean-Benoit , Schreck Benoit , Rouaud Tiphaine , Roy Monica , Derkinderen Pascal , Challet-Bouju Gaëlle
Published: November 2023

Objective A large body of literature has examined the links between the use of dopamine replacement therapy (DRT) in Parkinson’s disease (PD) and the development of “impulsive-compulsive behaviors (ICBs).” Little is known regarding the link between the development of ICBs and health-related quality of life (HRQOL). We aimed to explore the factors that are associated with poorer HRQOL, especially in relation to DRT-induced ICBs, in a sample of PD patients.Methods This PARKADD (PARK: PARKinson’s disease; ADD: behavioral ADDictions) study was a prospective case‒control study initially designed to assess the factors associated with ICBs in PD patients. A prospective clinical follow-up was added, aiming to capture the long-term evolution of HRQOL in relation to ICBs occurring or worsening after the beginning of PD. We focused on sociodemographic and PD characteristics and the history or presence of ICBs. HRQOL was measured using the Parkinson’s Disease Questionnaire-8. A multivariate linear regression was performed to identify factors related to poorer HRQOL.Results A total of 169 patients were eligible for the follow-up study. The presence of an ICB, a higher levodopa equivalent daily dose (LEDD) and a longer PD duration were significantly associated with poorer HRQOL, with an interaction between LEDD and PD duration.Conclusion The presence of an ICB was related to poorer HRQOL and should be considered a crucial factor for the management of PD patients. Several studies were recently published that provide guidelines for the management of these patients, with recommendations based on two key principles: prevention and specific treatment.
Investigation of structural, dielectric, impedance, and mechanical properties of hydroxyapatite-modified barium titanate composites for biomedical applications
Authors: Ibrahim Khalid Elfaki , Kassim Hamoud A.
Published: November 2023

This report presents the synthesis of pristine barium calcium titanate (BCT) and composite samples of [x(HA)–100 − x(BCT)]; (0 ≤ x ≤ 20) through solid-state reaction with microwave sintering. Hydroxyapatite (HA)–BCT composites have been developed to minimize grain growth, thereby boosting the material’s physical, mechanical, and electrical properties. The evaluated samples were examined for the Fourier transform-infrared spectra, and the results showed a correlation with the X-ray diffraction patterns. The real and imaginary dielectric permittivity was applied to determine the AC conductivity, and the findings indicate a drop in the frequency exponent values (S) from 1 to 0.67 for samples with x = 0. Similarly, for samples with x = 5, the value of S decreases from 0.90 to 0.55. For samples with x = 10, the value of S reduces from 0.7 to 0.54. Lastly, for samples with x = 20, the value of S decreases from 0.63 to 0.45. The exponent S and temperature relationship may be attributed to a thermal activation mechanism. The grains and grain boundary resistivity were estimated using a Cole–Cole plot, and the results showed that the grain boundary resistivity is higher in comparison to the resistivity exhibited inside the grains. This demonstrated the distinct electrical conductivity at the interfaces between the grains in comparison to the interior of the grains. The analysis of hardness indicates that the average hardness of the samples ranges from 5.22 to 4.77 GPa, which is maintained at different HA concentrations. The data suggest that this composite may have the potential to be a biomedically helpful substance.
Identification of tropical wood species in paper: a new chemotaxonomic method based on extractives
Authors: Flaig Max L. , Berger Jens , Wenig Philip , Olbrich Andrea , Saake Bodo
Published: November 2023

The European Deforestation Regulation 2023/1115 (EUDR) prohibits trading of wood and wood products obtained from illegal logging on the EU market. While the identification of solid wood via anatomy, chemistry and genetics has already been established, there is a lack of identification methods for pulp and paper that complement anatomy. This publication presents a newly developed chemotaxonomic method for identifying mixed tropical hardwood (MTH) species in pulp and paper products based on their extractives analyzed with thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). The measured data was processed and compared to identify marker substances and was then merged into a fingerprint database for identifying MTH species in paper of unknown composition. As database references, fully bleached kraft pulps were produced from 38 anatomically identified wood samples and then cryo-ball milled and extracted successively with n-hexane and acetone. The results show that the remaining wood extractives generated from bleached pulps are specific enough to find chemical relevant marker substances to detect MTH species. As chemical composition and anatomy are independent characteristics of wood, this paper makes a completely independent method available, which potentially improves the screening for Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) protected species.
Effects of sildenafil on Doppler parameters, maternal and neonatal outcomes in the active labor phase of low-risk pregnancies: a randomized clinical trial
Authors: Marsosi Vajiheh , Haghighi Ladan , Nasimi Parinaz Hamed , Ghaemi Marjan , Navaee Saimaz
Published: November 2023

Objectives

The benefits of sildenafil by increasing blood flow in the improvement of Doppler parameters of umbilical (UA), uterine (UtA), and fetal middle cerebral arteries (MCA) remain uncertain. On the other hand, insufficient blood flow during uterine contractions in labor can lead to decrease blood supply and fetal distress. Therefore, we aimed to assess the changes in fetal Doppler indices and maternal and neonatal outcomes following the use of sildenafil in the active phase of labor in low-risk pregnancies with healthy fetuses.

Methods

This randomized double-blinded controlled trial was conducted on 70 pregnant single low-risk, pregnant women. The patients were randomly assigned into two groups receiving sildenafil (n=35) or placebo (n=35) when the active phase of labor was initiated. Doppler parameters were assessed at baseline as well as 3 h after that. Indeed, the maternal and neonatal outcomes were compared between groups.

Results

The Doppler parameters including the pulsatility index of MCA, UA, and left and right UtA remained unchanged after the administration of sildenafil. Neonatal outcomes including birth weight, PH of the umbilical artery, Apgar score, respiratory distress syndrome, and neonatal intensive care unit admission as well as maternal outcomes such as cesarean section rate and the occurrence of intrapartum/postpartum hemorrhage had no difference between groups.

Conclusions

The use of sildenafil in the active phase of labor in low-risk pregnancies may not be beneficial in improving Doppler parameters in MCA, umbilical, and uterine arteries and thus may not improve pregnancy outcomes.
Elucidating the Adoption of Electronic Information Resources: A Case Study of Kuwait University Library
Authors: Alrashidi Abdulaziz , AlAwadhi Suha
Published: November 2023

Kuwait University Library has invested in electronic information resources (EIR) to facilitate users’ access to library materials. However, this has been insufficiently investigated to identify the factors that influence the use of EIR. Therefore, this study aims to explore the factors influencing the use of EIR by faculty members at Kuwait University, as the study further aims to enhance library services. Specifically, the study uses a modified technology acceptance model (TAM) to investigate whether the perceived ease-of-use, the perceived usefulness, and prior experience of using EIR affect their adoption. The EIR adoption, consequently, impacts the faculty’s academic performance. A mixed-method approach was adopted using the questionnaire and interview tools sequentially to collect primary data from faculty members at the College of Social Science, Kuwait University. Out of 116 questionnaires sent to participants, 48 were returned, yielding a 41 % response rate, which was supplemented with ten semi-structured interviews. The quantitative results, which were supported by the qualitative findings, indicate that the perceived ease-of-use, the perceived usefulness, and prior experience significantly influenced the adoption of EIR, and that adoption significantly impacted the academic performance. Moreover, the qualitative findings revealed the challenges that EIR users encountered. Recommendations and future research are also discussed.
Applying Different Concepts and Conceptions of Legitimacy to the International Level: Service, Free Group Agents, and Autonomy
Authors: Scherz Antoinette
Published: November 2023

International institutions are facing increasing criticism of the legitimacy of their authority. But what does it mean for an international institution to be legitimate? Arthur Applbaum’s latest book provides a convincing new concept of legitimacy, namely, the power-liability view, and a new normative conception, the free group agent account. However, it is not clear how they can be applied to the international level. First, this paper examines how different concepts of legitimacy can be applied to international institutions. Second, it assesses three different conceptions of legitimacy, namely, the service conception, Applbaum’s free group agent account and the autonomy-based conception for the international level. It outlines how on the last conception, international institutions’ legitimacy depends on three different aspects required to protect autonomy: the political power of the institution; its purpose; and its relation to other institutions. Finally, the paper argues that the creation of an international institution should be seen as part of relational legitimacy and that state consent plays an important role to protect the political autonomy of peoples.
Determination of rare earth elements in Algerian bentonites using k
0-NAA method
Authors: Hamidatou Lylia , Arbaoui Fahd , Chahra Radji , Slamene Hocine , Djebli Kamel , Boucherit Mohamed Nadir
Published: November 2023

This work focused the determination of the rare earth elements (REE) in Algerian bentonites named Mos and Mag using k
0-NAA method. Eleven rare earth elements such as Ce, Nd, La, Sc, Sm, Yb, Tm, Ho, Tb, Eu and Lu were determined. Results revealed that the total light REE (LREE) in Mos (168 ppm) is higher than in Mag (68.5 ppm). In addition, the ratio of total LREE (LREE) to the total heavy rare earth elements (HREE) found to be 6.40 in Mag and 27.6 in Mos which indicates that Mos is highly rich with REE than Mag. Ce and Eu correspond to the highest and lower trace of REE in both bentonites, respectively. The concentration of Sc, Tb and Ho are comparable in two materials. All results are compared with other data of literature in terms of La, Sc, Ce, Nd, Sm and Yb. Amounts and the proportion of LREE comparing to THREE are discussed in this study.
Our Bodies as Multi-storied Communities: Ethics and Practices
Authors: Lee Poh Lin
Published: November 2023

In this article, I introduce and develop an outline of the ethics and practices that invite us to recognize our bodies as multi-storied communities and to engage in decolonial feminist co-research. In discussing how we might come to these practices I share multimedia fragments of co-research, alongside a person I'm consulting with. This gives the reader the chance to see these ideas and practices in the journey of becoming rather than from a position of having reached a certain destination. This article offers a unique way of unpacking therapy sessions together with the person at the center and demonstrates the need to question the very notion of our bodies as singular and how that affects our practice. It contributes to the literature by calling into question taken-forgranted notions of our body and thereby how to engage, involve, and connect with body-inclusive practices in therapy.
Significance of thyroperoxidase and thyroglobulin antibodies in medically treated Graves’ disease
Authors: Constantinescu Stefan Matei , Hospel Julien , Daumerie Chantal , Alexopoulou Orsalia , Maiter Dominique , Burlacu Maria-Cristina
Published: November 2023

Background

Thyroperoxidase (TPOAb) and thyroglobulin (TgAb) antibodies are highly prevalent in Graves’ disease (GD), but their significance is controversial.

Methods

We retrospectively analyzed TPOAb and TgAb levels and evolution in 136 patients with newly diagnosed GD between 2000 and 2022, treated with anti-thyroid drugs (ATD) in a block-and-replace (B+R) regimen for at least 12 months and followed up for at least 1 year after ATD discontinuation or until disease relapse.

Results

At diagnosis, 98 out of 136 (72%) patients were TPOAb positive and 73 out of 136 (54%) patients were TgAb positive. The presence of TPOAb or TgAb antibodies at diagnosis was generally not related to GD presentation and did not influence the risk of relapse (P = 0.304 and P = 0.348, respectively). There was less TED (thyroid eye disease) in TgAb-positive patients than TgAb-negative patients at diagnosis (11 out of 73 (15.1%) versus 21 out of 63 (33.3%) P = 0.012). In contrast, the presence of TPOAb at diagnosis was not associated with TED (P = 0.354). The absence of TgAb at diagnosis (P = 0.05) and time to euthyroidism (P = 0.009), but not smoking or TRAb levels, were associated with TED in multivariate logistic regression. TPOAb and TgAb levels during treatment and after its discontinuation were not predictive of relapse, except for lower titers of TgAb at 18 months in patients who relapsed (P = 0.034).

Conclusion

In GD patients treated with a first course of ATD in a B+R regimen we observed lower titers of TgAb at the end of treatment in patients who relapsed and a significant protection against TED in patients with positive TgAb at diagnosis, irrespectively of TPOAb.
A new affine inhibitor of sodium pump thiacalix[4]arene С-1193 increases the intracellular concentration of Ca ions and modifies myometrium contractility
Authors:   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Veklich Т. О. , Cherenok S. О. ,   Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv;, Tsymbalyuk О. V. ,   Educational and Scientific Institute of High Technologies, Taras Shevchenko National University of Kyiv, Ukraine, Shkrabak О. A. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Karakhim S. O. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Selihova A. I. ,   Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv;, Kalchenko V. І. ,   Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv;, Kosterin S. O. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Published: November 2023

The methods of enzymatic and kinetic analysis were used to demonstrate that thiacalix[4]arene-bis-hydroxymethylphosphonic acid С-1193 had the inhibitory effect (І0.5 = 42.1 ± 0.6 nM) on Na+,K+-ATPase activity in the plasma membrane of myometrium cells with no effect on the relative activity of other ATPases localized in this subcellular structure. The method of confocal microscopy and Са2+-sensitive fluorescent probe fluo-4 were used to demonstrate that thiacalix[4]arene С-1193 increased the intracellular concentration of Ca ions in the immobilized uterine myocytes. The tenzometric studies proved that С-1193 (10 and 100 μМ) increased the isometric phasic contractions, induced via the paths of both electromechanical (depolarization with high-potassium solution) and pharmacomechanical (application of uterotonic hormone oxytocin, neurotransmitter acetylcholine or selective agonist of muscarinic acetylcholine receptors cevimeline) coupling. Application of thiacalix[4]arene С-1193 as a selective and effective inhibitor of Nа+,K+-ATPase may be useful both for studyng the regulation of ion homeostasis in smooth muscle cells and creation of new uterotonics based on the calixarene core. Keywords: contractility mechanokinetics, myometrium, Na+‚K+-АТРase, thiacalix[4]arene
Gamma-aminobutyric acid modulates antioxidant and osmoprotective systems in seedlings of Triticum aestivum cultivars differing in drought tolerance
Authors:   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv, Kolupaev Yu. E. ,   Poltava State Agrarian University, Poltava, Ukraine,   State Biotechnological University, Kharkiv, Ukraine;, Shakhov I. V. ,   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv;,   State Biotechnological University, Kharkiv, Ukraine;, Kokorev A. I. ,   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv;, Kryvoruchko L. ,   Poltava State Agrarian University, Poltava, Ukraine, Yastreb T. O. ,   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv;,   Crop Research Institute, Prague, Czech Republic
Published: November 2023

The stress-protective effects of plant neurotransmitters, including gamma-aminobutyric acid (GABA) have been intensively examined in recent years. However, studies on the GABA influence on stress protective systems in bread wheat cultivars with different drought adaptation strategies are still lacking. The aim of this work was to estimate the GABA effect on the state of antioxidant and osmoprotective systems in etiolated seedlings of two wheat cultivars differing significantly in drought tolerance, namely Doskonala (non-drought-resistant) and Tobak (drought-resistant) under model drought induced by PEG 6000. Two-day-old seedlings were transferred to 15% PEG 6000 and incubated for two days in the absence or presence of GABA. Treatment with 0.1 and 0.5 mM GABA significantly reduced the growth-inhibitory effect of PEG 6000 on the roots and shoots of both cultivars, but to a greater extent on those of non-resistant Doskonala. It was shown that GABA treatment reduced drought-induced accumulation of H2O2 and MDA, stabilized SOD and GPX activity, the level of sugars, anthocyanins and flavonoids in seedlings of both cultivars. Meanwhile GABA treatment enhanced the stress-induced increase in proline content in the Doskonala cultivar, but decreased it in the Tobak, completely prevented stress induced decrease in anthocyanins and flavonoids level in the Tobak and only partially in Doskonala cultivar. Thus, the stabilization of the stress-protective systems functioning in the wheat cultivars and variety-dependent differences in response to GABA were revealed. Keywords: anthocyanins, antioxidant system, drought resistance, gamma-aminobutyric acid, oxidative stress, proline, Triticum aestivum
Investor sentiment based on search engine data for predicting stock returns in Indonesia industrial sector
Authors: Hidayat Yusuf Murtadlo , Nugraha Nugraha , Disman Disman , Sari Maya , Bustam Muhammad Rayhan
Published: November 2023

This study aims to investigate investor sentiment and its effect on the industrial sector in Indonesia. In the study, investor sentiment was extracted from data obtained from search engines. Then the data were used to see how the sentiment affected the stock return in each listed industrial company. Fifteen industrial sector companies listed on the stock exchange were selected; each was analyzed for their search volume and the effect on stock returns using panel data regression from March 2020 to April 2022. The result shows that investor sentiment affects the level of stock returns in the industrial sector in Indonesia. This result indicates that with the increase in search volume on search engines, which reflects positive sentiment, there will be an increase in stock trading transactions and vice versa. This study's findings will help investors make investment decisions, especially in the industrial sector.
Digital entrepreneurship strategy in the tourism business of the tourism 4.0 era
Authors: Kurniati Poni Sukaesih , Suryanto Suryanto
Published: November 2023

This research analyzes digital entrepreneurship strategies by tourism industry players in Tourism 4.0. The research method used in this research is descriptive with a qualitative approach. Primary data sources come from the results of in-depth interviews with informants. In comparison, the secondary data sources are obtained from the search results of research results and statements of informants published in the media. The data that has been obtained is triangulated before being analyzed. The study results stated that digital entrepreneurship in the Indonesian tourism industry is multiplying. Several factors that support the growth of digital entrepreneurship include internet penetration, large population demographics, and digitization in the tourism industry. Digital entrepreneurship actors in the tourism industry are implementing several strategies to survive during and after the Covid-19 pandemic and entering the era of Tourism 4.0. This strategy successfully attracts tourists to continue to carry out tourism activities.
Tourist satisfaction in era Society 5.0 as a marketing strategy
Authors: Anggraeni Tuti , Gaffar Vanessa , Disman Disman , Dewi Dirgantari Puspo , Handayani Trustorini
Published: November 2023

This research aims to develop a marketing strategy for the Society 5.0 era by increasing tourist satisfaction in the lodging industry's business sector. Utilizing a quantitative approach with online data distribution, the sample in this study is 128 respondents. The PLS-SEM data analysis technique was used to analyze the questionnaire data. The study's results indicate that technological innovation services and tourist engagement influenced tourist satisfaction. In contrast, human innovation services, which have no direct impact on tourist satisfaction, must first be filtered through the variable measuring tourist engagement. The engagement of tourists is a moderating variable that influences tourist satisfaction. As technological and human innovation services directly experienced by tourists, they will affect tourist satisfaction. This research allows business actors in the lodging establishment industry to develop marketing strategies that increase tourist satisfaction, thereby increasing tourist trust and repeated visits in the future.
How do University Students Learn: Learning Styles and Approaches in the Context of Subjective Quality of Higher Education Teaching and Learning Effectiveness
Authors:   University of Hradec Králové, Juklová Kateřina
Published: November 2023

This paper examines the styles and approaches to learning in contemporary higher education students. These individual characteristics are seen as results of the interaction between student individuality and the learning environment stimuli. The presented research is based on the assumption of existing interactions among the nature of study environment, the student’s approach to learning and his/her study effectiveness. Research results confirm this assumption and enable to analyze findings in the context of a specific learning environment.
English Oral Skills Training through Theater Performance in an EFL Setting
Authors:   Chaoyang University of Technology, Chen Kate Tzu-Ching , Liao Dominique Ying-Chih ,   National Chung Hsing University
Published: November 2023

We examined the use of dramatic/theater presentation for teaching oral skills to 37 Taiwanese EFL undergraduate students, with the main goal being to determine whether such strategies and performance experiences positively support oral skills in terms of motivation and achievement. Data were collected via performance evaluations, observations, a seminar, individual interviews, and a questionnaire. Results indicate significant increases in learner motivation and oral English achievement. Students were actively engaged and willing to put significant time and effort into the project. However, the process strongly affected some students in terms of performance-related stress.
Prevalence of dyslipidemia, atherogenic and cardiovascular risk in overweight and obese adolescents
Authors: Andrades Clara dos Santos de , Poletti Victória Volkweis , Closs Vera Elizabeth , Gustavo Andreia da Silva , Oliveira Margareth da Silva , Donadio Márcio Vinícius Fagundes , Feoli Ana Maria Pandolfo
Published: November 2023

Abstract Objective: To analyze the lipid profile and cardiovascular risk of overweight and obese adolescents and correlate the findings with anthropometric measurements. Methods: This is a cross-sectional study on overweight and obese adolescents of both sexes (aged 14 to 18 years old). The collected variables were sex, weight, height, age, total cholesterol, triglycerides, High-density lipoprotein (HDL) and low-density lipoprotein (LDL). The Atherogenic Index of Plasma and Castelli Risk Indices I and II were calculated. These indices were classified into cutoff points to stratify cardiovascular risk. The anthropometric profile was evaluated by Z score according to Body Mass Index for age. Significance level was considered as p≤0.05. Results: A total of 146 adolescents participated in the study; the mean age was 16.4±1.1 years and most of them were girls (74.7%) and obese (52.7%). The prevalent dyslipidemias were high triglycerides (47.9%), LDL (26.7%), total cholesterol (37.7%), and low HDL (46.6%). Most adolescents presented increased atherogenic risk according to the Atherogenic Index of Plasma (55.5%); 15.1% presented high cardiovascular risk according to Castelli Risk Index I; and 13.7%, according to Castelli Risk Index II. Boys presented higher values of anthropometric measurements and Castelli Risk Indices I and II in relation to girls — who, conversely, presented higher values of HDL. There was a positive correlation of the Z score with Atherogenic Index of Plasma and a negative correlation with HDL. Conclusions: The adolescents of the study presented high prevalence of cardiovascular and atherogenic risk according to the evaluated indices. In addition, the increased cardiovascular risk was correlated with higher Body Mass Index.
Gradismo e Cladismo no Ensino em uma Análise Foucaultiana
Authors: Chelala Ana Laura Pantoja , Vieira Eduardo Paiva de Pontes , Chaves Silvia Nogueira
Published: November 2023

RESUMO O percurso analítico deste texto se dirige aos espaços de constituição dos saberes e vislumbra relações de força que problematizam questões atinentes aos sistemas de classificação biológica e ao ensino, objetivando tornar visível as instâncias em que a Sistemática Evolutiva pode representar descontinuidade em relação à Sistemática Lineana. Contemporaneamente, o discurso filogenético posiciona-se como saber mais adequado ao estabelecimento das relações evolutivas, contudo, nos espaços de ensino ele sofre interdições o que permite supor que a formação de professores não lida satisfatoriamente com a dinâmica de algumas construções cientificas. Assim, pensa-se a produção do conhecimento científico para além da simples aceitação de uma verdade.
GESTÃO EDUCACIONAL E A DEFASAGEM NA APRENDIZAGEM: A ATUAÇÃO DOS DIRIGENTE ESCOLARES PARA A SUPERAÇÃO DAS FRAGILIDADES EDUCACIONAIS
Authors: Ramalho Brenda , Vera Marymili Segura
Published: November 2023

O presente artigo tem como objetivo analisar o papel dos gestores escolares para a superação da defasagem na aprendizagem de seus estudantes. Para tanto, recorreu-se à revisão de literatura amparada nas contribuições clássicas de teóricos com notória validação no campo acadêmico a fim de se obter subsídios para a realização da discussão e análise crítica sobre a atuação desses profissionais frente a um desafio educacional cujos impactos não se restringem à vida escolar dos sujeitos matriculados. Nesse sentido, essa pesquisa destaca os conceitos de Libâneo (1994, 2001, 2011) e Lück (2000) sobre a gestão educacional e as atribuições e responsabilidades inerentes à função dos gestores escolares enquanto agentes responsáveis pela organização geral e adequada condução do trabalho pedagógico das instituições de ensino sob sua administração. Sobre a avaliação institucional, recorreu-se principalmente aos ideias de Luckesi (2011) e, especificamente em relação à compreensão da defasagem na aprendizagem e os possíveis obstáculos à superação dessa condição educacional, foram encontradas contribuições teóricas relevantes nos estudos de Vygotsky (2007) e Ausubel (2003). Entre as considerações finais vale destacar a indispensabilidade de encaminhamento das práticas avaliativas à compreensão das fragilidades institucionais, assim como a necessidade contínua de (re)formulação do planejamento estratégico desses espaços escolares e análise objetiva da própria prática e responsabilidade enquanto gestores.
Comparative Transcriptome Analysis of Candidate Genes Associated with Mycelia Growth from a He-Ne Laser with Pulsed Light Mutant of Phellinus igniarius (Agaricomycetes)
Authors: Dong Yating , Ma Haile , Sun Ling , He Ronghai , Ye Xiaofei , Gan Bingcheng , Zhang Qin , Gong ZongJun , Han Xing , Duan Xinlian , Yan Junjie
Published: November 2023

A mutant Phellinus igniarius JQ9 with higher mycelial production was screened out by He-Ne laser with pulsed light irradiation, the mechanism underlying the higher mycelial production is still unknown. This study aims to obtain a comprehensive transcriptome assembly during the Ph. igniarius liquid fermentation and characterize the key genes associated with the mycelial growth and metabolism in Ph. igniarius JQ9. Our transcriptome data of Ph. iniarius JQ9 and the wild strain were obtained with the Illumina platform comparative transcriptome sequencing technology. The results showed that among all the 346 differentially expressed genes (DEGs), 245 were upregulated and 101 were downregulated. Candidate genes encoding endoglucanase, beta-glucosidase, cellulose 1,4-beta-cellobiosidase, glycoside hydrolase family 61 protein, were proposed to participate in the carbohydrate utilization from KEGG enrichment of the starch and sucrose metabolism pathways were upregulated in Ph. igniarius JQ9. In addition, three candidate genes encoding the laccase and another two candidate genes related with the cell growth were higher expressed in Ph. igniarius JQ9 than in the wild type of strain (CK). Analysis of these data revealed that increased these related carbohydrate metabolism candidate genes underlying one crucial way may cause the higher mycelia production.
Crude Polysaccharides from Mushrooms Elicit an Anti-Allergic Effect Against Type 1 Allergy In Vitro
Authors: Isikhuemhen Omoanghe S. , Anike Felicia N. , Enemudo Judith O. , Mizuno Masashi , Alagbaoso Chidube A.
Published: November 2023

Type 1 allergic disease is a global challenge, hence the search for alternative therapies. Mushrooms have several medicinal and health benefits. However, scant data exist on the anti-allergic properties of polysaccharides from fruiting bodies (FB) and mycelia of mushrooms. We used an in vitro co-culture system comprising Caco-2 cells (intestinal epithelial colorectal carcinoma cell line) and RBL-2H3 cells (cell line from rat basophilic leukemia cells). Reduction in degranulation of mast cells indicated anti-allergy properties. The inhibitory effect of crude polysaccharides from different mushroom FB and mycelia on β-hexosaminidase release from RBL-2H3 cells was measured. Results showed that crude polysaccharides from the FB of Inonotus obliquus exhibited a significant inhibitory effect on β-hexosaminidase release and lowered it by 16%. Polysaccharides from the FB of Lentinus squarrosulus, and Pleurotus ostreatus did not exhibit a significant reduction in β-hexosaminidase. However, crude polysaccharides from their mycelia had a significant inhibitory effect, resulting in up to a 23% reduction in β-hexosaminidase activity. Among fungi showing degranulation properties, crude polysaccharides from their mycelia showed more potent action against degranulation than their corresponding FB. Polysaccharides extracted from FB and or mycelia, of selected mushrooms, possess anti-allergic properties that could be harnessed for use in alternative allergy therapies.
Anatomical and chemical characterization of leaves from Oreopanax spp. (Araliaceae), the Mexican xoco tamale food complex
Authors: Guerrero-Analco José A. , Angeles-Alvarez Guillermo , Lascurain-Rangel Maite , Avendaño-Reyes Sergio , Kiel-Martínez Ana L. , Bonilla-Landa Israel , Linares Edelmira , Bye Robert , Guillén Larissa
Published: November 2023

Background: Based on the concept of “plant species complex,”, defined as a group sharing local names and morphological, aromatic, and curative properties, we analyzed the leaves of three species of the genus Oreopanax that are used as wrappers for tamales called “xocos” or “chocos” in Veracruz, Mexico, searching for common traits.
Question: Do leaves of the genus Oreopanax form an ethnobotanical food complex sharing chemical and anatomical characteristics?
Studied species / data description: Leaves from three species of the genus Oreopanax: O. capitatus, O. echinops, and O. flaccidus.
Study site and dates: Leaves of O. capitatus and O. echinops were recollected on January 25 and 26, 2021, in the Clavijero Botanic Garden of the Instituto de Ecología, A. C. in Xalapa, Veracruz; leaves of O. flaccidus were recollected in Atapalchico, Tlacolulan, Veracruz.
Methods: Chemical analyses consisted of oil extraction of the studied species' leaves, which were then injected into a gas chromatographer coupled to a mass spectrometer (GC-MS). Anatomical analyses included: fixation, paraffin sectioning, and staining of leaf sections of the three species. Observations were performed with a compound microscope using a bright field or UV light.
Results: For the first time, we are reporting major volatile compounds common in the three analyzed species (several aliphatic and aromatic alcohols, and terpenoids). The three species present resin canals in the mesophyll and the cortex of the midrib of the leaf.
Conclusions: The studied Oreopanax species form an ethnobotanical food complex since they share similar uses, smells, and tastes.
Approaches, potential, and challenges in the use of remote sensing to study mangrove and other tropical wetland forests
Authors: Chávez Daniel , López-Portillo Jorge , Gallardo-Cruz J. Alberto , Meave Jorge A.
Published: November 2023

Tropical wetland forests are fragile ecosystems facing critical risks due to global warming and other anthropogenic threats. Hence, gathering accurate and reliable information on them is urgent. Although remote sensing has demonstrated great potential in studying terrestrial ecosystems, remote sensing-based wetland forest research is still in an early stage of development. Mapping wetland forests, particularly mangrove forests, was an initial goal of this approach and is a task that still faces methodological challenges. Initially based on aerial photography only, wetland forest mapping through remote sensing underwent explosive diversification after the launching of artificial satellites in the 1970s. Later, precision in wetland forest mapping increased with the combination of hyperspectral, multispectral, and high and very high resolution imagery. Accurate delimitation of wetland forest extent is also necessary to assess their temporal dynamics (losses, gains, and horizontal displacement). Despite the prevalence of mapping studies, current remote sensing-based research on wetland forests addresses new questions and novel aims, such as describing and predicting wetland forest attributes through mathematical modeling. Although this approach has made substantial progress in recent decades, modeling and predicting wetland forest attributes remain insufficiently explored fields of research. Combining active and passive sensors is a promising alternative to provide a more accurate picture of these communities’ attributes. In particular, LiDAR and radar-based technologies may help overcome difficulties encountered in older studies. In the future, we will witness conceptual and methodological progress that will enable us to surmount the remaining challenges.
Flawed reports can harm: the case of supervised consumption services in Alberta
Authors: Salvalaggio Ginetta , Brooks Hannah , Caine Vera , Gagnon Marilou , Godley Jenny , Houston Stan , Kennedy Mary Clare , Kosteniuk Brynn , Livingston Jamie , Saah Rebecca , Speed Kelsey , Urbanoski Karen , Werb Dan , Hyshka Elaine
Published: November 2023

Supervised consumption services have been scaled up within Canada and internationally as an ethical imperative in the context of a public health emergency. A large body of peer-reviewed evidence demonstrates that these services prevent poisoning deaths, reduce infectious disease transmission risk behaviour, and facilitate clients’ connections to other health and social services. In 2019, the Alberta government commissioned a review of the socioeconomic impacts of seven supervised consumption services in the province. The report is formatted to appear as an objective, scientifically credible evaluation of these services; however, it is fundamentally methodologically flawed, with a high risk of biases that critically undermine its authors’ assessment of the scientific evidence. The report’s findings have been used to justify decisions that jeopardize the health and well-being of people who use drugs both in Canada and internationally. Governments must ensure that future assessments of supervised consumption services and other public health measures to address drug poisoning deaths are scientifically sound and methodologically rigorous. Health policy must be based on the best available evidence, protect the right of structurally vulnerable populations to access healthcare, and not be contingent on favourable public opinion or prevailing political ideology.
Designing Conversational Dashboards for Effective Use in Crisis Response
Authors: Ruoff Marcel ,   Karlsruhe Institute of Technology, Gnewuch Ulrich ,   Karlsruhe Institute of Technology, Maedche Alexander ,   Karlsruhe Institute of Technology, Scheibehenne Benjamin ,   Karlsruhe Institute of Technology
Published: November 2023

Governments and health organizations are increasingly using dashboards to provide real-time information during natural disasters and pandemics. Although these dashboards aim to make crisisrelated information accessible to the general public, the average user can have a hard time interacting with them and finding the information needed to make everyday decisions. To address this challenge, we draw on the theory of effective use to propose a theory-driven design for conversational dashboards intended for crisis response that can improve users’ transparent interaction with these dashboards and facilitate access to crisis-related information during crises. We instantiate our proposed design in a conversational dashboard for the COVID-19 pandemic that enables natural language interaction in spoken or written form and helps users familiarize themselves with the use of natural language through conversational onboarding. The evaluation of our artifact shows that being able to use natural language improves users’ interaction with the dashboard and ultimately increases their efficiency and effectiveness in finding information. This positive effect is amplified when users complete the onboarding before interacting with the dashboard, particularly when they can use both natural language and mouse interaction. Our findings contribute to research on dashboard design, both in general and in the specific context of crisis response, by providing prescriptive knowledge for extending crisis response dashboards with natural language interaction capabilities. In addition, our work contributes to the democratization of data science by proposing design guidelines for making information on crisis response dashboards more accessible to the general public.
Unconquerable: The Story of John Ross, Chief of the Cherokees, 1828–1866
Authors: Byrn Jonathan
Published: November 2023

Book review
Doing Your Part for National Security: Providing Quality Care to Our Military and Veterans
Authors: Wilmoth Margaret Chamberlain
Published: November 2023

Civilian health professionals can play a significant role in our national security as it relates to medical readiness of the military. Members of the Reserve Component and many Veterans receive their health care in the civilian sector, thus all North Carolina health professionals need to understand the unique issues affecting this population. This issue high­lights current challenges facing our military, their families, and our Veterans, and authors offer suggestions for provid­ing quality care to this population.
Bridging the Gap: Delivering Culturally Sensitive Care for Military-connected Patients in Community Settings
Authors: Kleiman Rear Admiral Matthew E. , Dolan Diana C. , Nevers Jennifer J.
Published: November 2023

Service Members, particularly members of the Reserve Component, seek medical and mental health care in their civilian communities. To the extent that providers communicate respect and value for military culture, they can better engage and enhance outcomes.
Anatomia argumentativa do Caso Ellwanger: análise dos votos dos Ministros do Supremo Tribunal Federal a partir do layout de Stephen Toulmin
Authors: Chaves Denisson Gonçalves , Andrade José Rogério de Pinho
Published: November 2023

A argumentação jurídica é uma obrigação constitucional para as sociedades que assumem o compromisso com o Estado Democrático de Direito. Entende-se que o Poder Judiciário brasileiro tem o dever de apresentar as justificativas para suas decisões, consoante reverbera o art. 93, IX da Constituição Federal de 1988. Todavia não basta que as razões sejam expostas é preciso que elas sejam avaliadas e que existam critérios para realização da análise de racionalidade das decisões judiciais. Nesse sentido, o objetivo deste trabalho é avaliar os argumentos dos Ministros do Supremo Tribunal Federal no Caso Ellwanger – Habeas Corpus nº. 82.424/RS, que trata da averiguação do configuração do antissemitismo como forma de racismo segundo art. 5º, XLII, versando sobre as temáticas da liberdade de expressão e discurso de ódio, de acordo com o layout argumentativo de Stephen Toulmin. Conclui-se que não existe uma homogeneidade de pensamento na Suprema Corte brasileira, apesar da concordância da não delimitação dos judeus como raça, percebeu-se uma linha confusa e diversificada de argumentos embasadores do direito de liberdade de expressão e sua aplicabilidade
Suprema desigualdade: uma releitura histórica do papel da Suprema Corte no sistema político norte-americano
Authors: Cunha Filho Marcio
Published: November 2023

Esta é uma resenha crítica da obra "Supreme Inequality: The Supreme Court's Fifty-Year Battle for a More Unjust America", de Adam Cohen.
O Direito às políticas públicas e à promoção da saúde para o desenvolvimento das mulheres
Authors: Sousa Maria Eliane Alves
Published: November 2023

Neste artigo aborda-se o Plano Nacional de Políticas para Mulheres (PNPM) sob a perspectiva de política pública para o desenvolvimento como direito humano. O Objetivo é analisar as três versões do PNPM para identificar suas características como política ampla de Promoção da Saúde. O estudo é qualitativo, mediante pesquisa teórica e documental sobre os direitos das mulheres em aspectos relacionados à atenção do Estado em políticas públicas, tendo a saúde como conceito e direito amplo. Os PNPMs apresentam importantes aspectos da abordagem integrativa entre a saúde e seus elementos constitutivos (alimentação, moradia, trabalho, educação, segurança, lazer etc.), essenciais ao desenvolvimento humano, sob a forma de combinação das capacitações e oportunidades que permitem ações (social, econômica, jurídica e política), em consonância com os objetivos, princípios e diretrizes da Promoção da Saúde. Conclui-se que, como política pública, o Plano traz respostas às necessidades das mulheres, de modo que podem contribuir para fomentar aspectos de cidadania e direitos que garantem condições de desenvolvimento em ambiente de respeito, paz, igualdade e liberdades. Portanto, é essencial que o Estado cumpra os compromissos assumidos e reconsidere suas decisões de ignorar as políticas específicas para mulheres, reinclua o PNPM no orçamento e efetive os programas das ações estratégicas.
Simvastatin attenuates diabetes mellitus erectile dysfunction in rats by miR-9-5p-regulated PDCD4
Authors: Weng YiMing , Mao YuanShen , Wang YanQiu , Jiao YuFan , Xiang Jun , Le Wei
Published: November 2023

DMED is a common complication of diabetes, for which new treatment methods are urgently required. Focused on DMED, the pharmacological mechanism of simvastatin (Sim) was probed. A model of DMED was made in rats with streptozotocin and orally medicated with Sim. Lentiviral vectors that interfere with miR-9-5p or PDCD4 were injected, and the erectile function, histopathology of cavernous tissue, and α-SMA expression were evaluated. Cavernous smooth muscle cells (CMSCs) obtained from DMED rats were treated with Sim and transfected with the plasmid vector that interferes with miR-9-5p or PDCD4 to observe cell viability and apoptosis. The binding relationship between miR-9-5p and PDCD4 was checked. After 8-week treatment with Sim, erectile function was improved and the corpus cavernosum injury was alleviated. Upregulating miR-9-5p or downregulating PDCD4 further improved erectile function and cavernous injury in rats. miR-9-5p targeted regulation of PDCD4. In vitro cell experiment results showed that Sim induced proliferation and reduced apoptosis of CSMCs by enhancing miR-9-5p-targeted regulating PDCD4 in vitro. Sim attenuates DMED in rats via miR-9-5p/PDCD4.