bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluoxetine for Anterior Ischemic Optic Neuropathy (AION); a Double Blind Randomized Clinical Trial
Authors: Abbasi Mohammad Hossein , Rimaz Shahnaz , Pourmousa Zahra , Janani Leila , Sanjari Mostafa Soltan
Published: February 2021

Background: Fluoxetine enhances the levels of brain-derived neurotrophic factor (BDNF); considering its known improving effects on neurogenesis and plasticity, it seems to improve the Anterior Ischemic Optic Neuropathy (AION). This study aimed to evaluate the effect of Fluoxetine on clinical prognosis of patients with AION.Methods: In this double-blind placebo-controlled randomized clinical trial, subjects with AION who were referred to Rasool Akram Hospital were divided into two study groups; the fluoxetine group that received 20 mg Fluoxetine daily(n=50) and the control group (n=50) that received placebo for a period of six months. Patients underwent clinical and paraclinical evaluations before and after the trial. This study was a registered trial with IRCT code IRCT20181109041596N1.Results: One hundred patients were enrolled from August 2019 to December 2020 and assessed in this study. Subjects in Fluoxetine group showed significant improvement in visual acuity in comparison to the placebo group with less score in LogMAR scale (P: 0.008 and 0.002, respectively), improvement in MD parameters of perimetry (P: 0.003 and 0.002, respectively), and decrease in VEP latencies (P (in 1st minute): <0.001 and <0.001, P (in 15st minute): 0.038 and 0.011, respectively). There were no differences in color vision, Rnfl in all dimensions, PSD parameter of perimetry or VEP amplitudes following the trial of Fluoxetine therapy (Ps> 0.05).Conclusion: Fluoxetine showed promising therapeutic value for patients with AION besides its safety as an additive treatment option to corticosteroids.
Allelopathic Potential of Papaver Somniferum L. on Seed Germination Against Three Different Varities of Zea Mays
Authors: Sidra Muntaha Tul , MUBARAK SAYEDA SARAH , SHERWANI FATIMA KHAN , AZEEM NAZMA
Published: February 2021

Aims

To evaluate the allelopathic effect of Papaver somniferum against the 3 varieties of Zea mays seeds cv. Azam, Pahari and Iqbal.
Methods

Aqueous extracts were made by soaking the powder of dried leaves of Papaver somniferum. For the aqueous extract treatment, the extract was soaked in distilled water for 24 and 48 hours separately. For mulching treatment, the seeds were sowed in soil and sprinkled powder of leaves. For litter, the petri dishes were grounded with randomly cut pieces of filter paper wetted with extract. For hot water treatment the water was boiled for 5 minutes. The powder was then mixed in boil water.
Results

Azam got effected in 24h extract in aqueous extract treatment while Pahari in 48h treatment. In mulching all the three varieties got inhibited by extract. Azam showed resistance toward the inhibitory effect of extract in litter experiments. Iqbal was affected in hot water extract.
Conclusion

It is concluded that the extracts obtained from Papaver somniferum showed inhibitory effects on all the three varieties except few exceptions of maize. The plumule and radical growth got affected the most.
The Radio-mitigative Effect of CpG-Oligodeoxynucleotides on Mice After Exposure to Carbon Ions Radiation.
Authors: Zhang Chao , Fu Hua , Zhu Xiang-hui , Li Sha , Tian Zhong-ze , Liu Hu , Hu Hao
Published: February 2021

Background: Heavy ion radiation constitutes a major health risk for astronaut in space flight, potential damage to healthy tissues surrounding the tumor target along its penetrating path should still be considered in hydrotherapy. Therefore, there is a demand for reliable countermeasure against heavy ions radiation. In this study, we will estimate the radiomitigative effect of CpG-ODN on immune tissues after carbon ions radiation (CIR). Methods: Firstly, the 30 days’ survival of mice was observed, peripheral blood cell was counted, the injury of three principal immune tissues (including bone marrow, thymus and spleen) was evaluated by histological examination, apoptosis and double strand breaks (DSB) were detected by TUNEL staining and γ-H2AX immunohistochemistry respectively, and cytokine (G-CSF, IL-6 and TNF-α) was measured by ELISA assay. Results: the 30 days’ survival improved, the injury of three principal immune tissues were obviously ameliorated, the number of γ-H2AX foci and TUNEL-positive nuclei decreased, and G-CSF, IL-6 and TNF-α expression increased by CpG-ODN treatment after CIR. Conclusion: CpG-ODN could enhanced mice survival, and ameliorate immune tissues injury, the mechanism may be that CpG-ODN induced cytokines production and inhibited the double strand breaks (DSB) and apoptosis in order to stimulate the generation and mobilization of the immune cells and reestablish immune system to combat bacterial infections.
Residual Large Trees Influence Short-term Succession Following a Volcanic Eruption in a Valdivian Temperate Rainforest
Authors: Hintz Lisa , Fischer Dylan , Ferrari Nina , Crisafulli Charlie M.S.
Published: February 2021

Airborne volcanic ejecta (tephra) can strongly influence forest ecosystems through initial disturbance processes and subsequent ecological response. Within a tephra-disturbed forest, large trees may promote plant growth and create favorable sites for colonization. Three primary ways trees can influence post-eruption vegetation response include: 1) amelioration of volcanic substrates, 2) as source propagules from the tree or from associated epiphytes, and 3) by sheltering understory vegetation, thereby increasing rate of recovery near tree bases. Here, we evaluate Valdivian temperate rainforest understory vegetation response and soil characteristics in close proximity to large trees that survived the 2015 eruption of Calbuco Volcano. Understory vegetative cover was higher near the base of trees for mosses, many epiphytes, and some herbaceous, shrub, and trees species. However, significant interactions with year of measurement, and individualistic responses by many species made generalizations more difficult. Small shrubs and trees in particular demonstrated patterns of recovery that were frequently independent of distance. In some cases, percent cover of colonizing vegetation actually increased far from trees by 2019. The soil surface was similarly variable where bare soil cover was associated with locations proximal to tree bases, but material shed from living and dead standing vegetation increased wood and litter abundances on the soil surface away from the base of trees. Soils near trees had lower pH, elevated organic matter, and higher nitrogen and carbon. Our results support the assertion that in this temperate rainforest ecosystem, large trees can modify edaphic conditions and provide important early refugia for vegetative regrowth following a tephra fall event. Nevertheless, complex interactions through time with species and growth form, suggest the influence of large trees on plant establishment and growth with close proximity tree boles is more complex than a simple facilitative model might suggest.
Synthesis of CA6/AlON Composites with Enhanced Slag Resistance
Authors: Liu Yunsong , Wang Enhui , Xu Linchao , Yang Tao , Hou Xinmei , He Zhijun , Liang Tongxiang
Published: February 2021

Aiming to improve the slag resistance of calcium hexaaluminate (CA6), different amounts of AlON have been introduced into CA6 using two approaches, i.e. one-step and two-step methods. The results show that both the two phases of CA6 and AlON are uniformly distributed when sintered at 1650 °C for 2 h in flowing nitrogen using two-step method. The optimized amount of AlON addition is determined to be 10 wt%. In addition, the reaction test method is performed and CA6/AlON composite exhibits much better slag penetration and corrosion resistance compared with pure CA6. The effect of AlON is also discussed.
Establishment and Characterization of a Feline Mammary Tumor Patient-Derived Xenograft Model
Authors: Chuang Hsiao-Li , Chang Yi-Chih , Huang Yi-Ting , Liao Jiunn-Wang , Lin Yi-Lo , Chen Ter-Hsin , Wang Yu-Chih
Published: February 2021

BackgroundFeline mammary tumor (FMT) is a relatively commonly diagnosed neoplasm in the cat. Development of new veterinary cancer therapies is limited by the shortage of in vivo models that reproduce tumor microenvironment and metastatic progression. ResultsFour FMT-patient‐derived xenografts (PDX) successfully established in NOD.Cg-Prkdcscid IL2rgtm1Wjl/SzJ mice. The overall success rate of PDX establishment was 36% (4/11). Histological, immunohistochemical, and short tandem repeat analysis showed a remarkable similarity between patient's tumor and PDX.ConclusionsIn this study, FMT-PDX model were established. The tumor grafts conserve original tumor essential features, including distant metastasis. FMT-PDX represents an available resource for bridging the biology of FMT with preclinical studies of FMT in cats.
Shortest Unique Representative Hidden Markov Model (SurHMM) for Detecting Protein Toxins, Virulence Factors and Antibiotic Resistance Genes
Authors: Xie Gary , Fair Jeanne M
Published: February 2021

Objective: Currently, next generation sequencing (NGS) is widely used to decode potential novel or variant pathogens both in emergent outbreaks and in routine clinical practice. However, the efficient identification of novel or diverged pathogenomic compositions remains a big challenge. It is especially true for short DNA sequence fragments from NGS, since sequence similarity searching is vulnerable to false negatives or false positives, as mismatching or matching with unrelated proteins. Therefore, this study aimed to establish a bioinformatics approach that can generate unique motif sequences for profiling searching, resulting in high specificity and sensitivity. Results: In this study, we introduced a shortest unique representative hidden Markov model (HMM) approach to identify bacterial toxin, virulence factor (VF), and antimicrobial resistance (AR) in short sequence reads. We first construct unique representative domain sequences of toxin genes, VFs, and ARs to avoid potential false positives, and then to use HMM models to accurately identify potential toxin, VF, and AR fragments. The benchmark shows this approach can achieve relatively high specificity and sensitivity if the appropriate cutoff value is applied.
Time-dependent efficacy of combination of silver-containing hydroxyapatite coating and vancomycin on methicillin-resistant Staphylococcus aureus biofilm formation in vitro
Authors: Hashimoto Akira , Miyamoto Hiroshi , Kii Sakumo , Kobatake Tomoki , Shobuike Takeo , Noda Iwao , Sonohata Motoki , Mawatari Masaaki
Published: February 2021

Objective
We developed a silver-containing hydroxyapatite (Ag-HA) coating to prevent periprosthetic joint infection (PJI). Methicillin-resistant Staphylococcus aureus (MRSA) is the main PJI-causing bacteria. Previously, we had reported the combined effect of Ag-HA coating and vancomycin (VCM) on MRSA biofilm formation 24 h after MRSA inoculation. In this study, we investigated the time-dependent efficacy of Ag-HA coating and VCM on MRSA biofilm formation on Ti discs in vitro by three-dimensional confocal laser scanning microscopic analysis.
Results
For the Ti VCM and HA VCM groups, the total biofilm volumes per area at 96 h after MRSA inoculation were significantly larger than those at 48 h after MRSA inoculation, respectively (p < 0.001). In contrast, for the Ag-HA VCM group, the total biofilm volume per area at 96 h was significantly smaller than that at 48 h (p < 0.0001). Moreover, 96 h after MRSA inoculation, the total biofilm volume per area of the Ag-HA VCM groups was significantly smaller than those of the Ti VCM and HA VCM groups (p < 0.0001). Thus, the combination of Ag-HA and VCM might be useful for the prevention of MRSA-associated PJI.
Maintenance of Skeletal Muscle Mass During FOLFIRINOX is a Favorable Prognostic Factor in Pancreatic Cancer Patients
Authors: Shin Dong Woo , Kim Minseok Albert , Lee Jong-chan , Kim Jaihwan , Hwang Jin-Hyeok
Published: February 2021

Objective: The study aimed to investigate the effect of body composition changes during chemotherapy on clinical outcomes in patients with pancreatic cancer.Results: In patients with locally advanced pancreatic cancer (LAPC), the cross-sectional area of skeletal muscle (SM) and adipose tissue (AT) at the level of third lumbar vertebra was measured. The SM and AT ratios indicated the changes during chemotherapy. The patients were classified into three groups based on these ratios: group 1, ≥1.00; group 2, 0.85-0.99; group 3, <0.85. The overall survival (OS) and surgical resection rates were estimated. Fifty-eight patients with LAPC who received first-line FOLFIRINOX were analysed. Fifteen (25.9%) patients who underwent resection showed maintained BMI, SM, and AT as compared to the patients who did not undergo resection. As the SM ratio decreased, the risk for death increased significantly. Further, the resection rate was significantly higher in patients with maintained SM compared to those with low SM ratio. On the contrary, the change in AT ratio was not associated with OS and resection rate; however, significant decrease in AT more than 15% showed poor clinical outcomes. Maintenance of SM during chemotherapy is a reliable prognostic factor indicating longer OS and higher resection rate.
Safety and Effectiveness Evaluation of A Two-Handed Technique Combining Harmonic Scalpel and Laparoscopic Peng’s Multifunction Operative Dissector in Laparoscopic Hemihepatectomy
Authors: Cai Jingwei , Jiang Guixing , Liang Yuelong , Xie Yangyang , Zheng Junhao , Liang Xiao
Published: February 2021

ObjectivesThis study was designed to evaluate the safety and effectiveness of a two-hand technique combining harmonic scalpel (HS) and laparoscopic Peng’s multifunction operative dissector (LPMOD) in patients who underwent laparoscopic hemihepatectomy (LHH).MethodsWe designed and conducted a case-control study nested in a prospectively collected laparoscopic liver surgery database. Patients who underwent LHH for liver parenchyma transection using HS + LPMOD were defined as cases (n = 98) and LPMOD only as controls (n = 47) from January, 2016 to May, 2018. Propensity score matching (1:1) between the case and control groups was used in the analyses. ResultsThe case group had significantly less intraoperative blood loss in mL (169.4 ± 133.5 vs. 221.5 ± 176.3, P = 0.03) and shorter operative time in minutes (210.5 ± 56.1 vs. 265.7 ± 67.1, P = 0.02) comparing to the control group. The conversion to laparotomy, postoperative hospital stay, resection margin, the mean peak level of postoperative liver function parameters, bile leakage rate and others were comparable between the two groups. There was no perioperative mortality. ConclusionsWe demonstrated that the two-handed technique combing HS and LPMOD in LHH is safe and effective which is associated with shorter operative time and less intraoperative blood loss compared with LPMOD alone. The technique facilitates laparoscopic liver resection and is recommended for use.
Extraordinary Spin to Orbital Angular Momentum Conversion on Guided Zone Plates
Authors: Acebal Pablo , Carretero Luis , Blaya Salvador
Published: February 2021

Focusing systems with high numerical aperture can be used to convert spin angular momentum into orbital angular momentum with efficiencies of 50%, while for low numerical apertures this conversion vanishes. In this paper, based on the properties of binary Fresnel zone plates, we propose a structure that is achieved by making an accurate selection of the width and the depth of the rings. This allows us to obtain a large increase in the spin to orbital angular momentum conversion of the resulting focusing fields, and it also has the special characteristic that the obtained conversion is higher for low numerical aperture structures, where standard focusing systems do not work. The ability of the system to perform this extraordinary conversion is demonstrated by FDTD methods and an analytical model developed using a combination of guided mode theory for the structure and Stratton-Chu diffraction theory.
Intra-fractional dosimetric analysis of image-guided adaptive intracavitary brachytherapy of cervical cancer
Authors: Yan Junfang , Zhu Jiawei , Chen Kai , Yu Lang , Zhang Fuquan
Published: February 2021

Background
To assess the intra-fractional dosimetric variations of image-guided adaptive brachytherapy of cervical cancer.
Methods
A total of 38 fractions (9 patients) undergoing brachytherapy for cervical cancer underwent a CT scanning for treatment planning (planning CT) and a CBCT scanning immediately prior to treatment (pre-treatment CBCT). Variations between images acquired within one applicator insertions (intra-application) were evaluated. The DVH parameters including volume, D90 HRCTV and D2cc OARs were recorded.
Results
The variations (mean ± SD) of the volume and D90 HRCTV are − 2.00 ± 3.26% and − 1.18 ± 4.47%, respectively. The variations of D2cc for bladder, rectum, sigmoid and small intestine are − 0.6 ± 17.05%, 9.34 ± 14.59%, 7.15% ± 20.49% and 1.52 ± 12.57%, respectively. Most of them are statistically nonsignificant except the D2cc for rectum, which showed a significant increase (P = 0.001). Using 5% and 10% uncertainty of physical dose for HRCTV at a 6Gy ⋅ 5 HDR schedule, the possibility of total EQD2 dose lower than 85Gy is close to 0% and 3%, respectively. Performing similar simulation at 15% and 20% uncertainty of a 4Gy physical dose for OARs, the possibility of total EQD2 dose exceeding 75Gy is about 70%. Less than 1% of the total EQD2 of OARs would exceed 80Gy.
Conclusions
Average intra-fractional dosimetric variation of HRCTV was small in a interval of less than 1 hour, and the possibility of total EQD2 exceeding 85Gy is higher than 97%. The intra-fractional dosimetric variations of OARs might result in an overdose for OARs in a single fraction or the whole treatment. It is necessary to detect unfavorable anatomical changes by re-imaging and take interventions to minimize applied doses and reduce the risk of complications.
Interface Induced Diffusion; Area Selective Interface Patterning
Authors: Gurbán S , Sulyok A , Menyhárd M , Baradács E , Parditka B , Cserháti C. , Langer G. A , Erdélyi Z
Published: February 2021

Interface induced diffusion had been identified in thin film system damaged by electron bombardment. This new phenomenon was observed in Al2O3 (some nm thick) / Si substrate system, which was subjected to low energy (5 keV) electron bombardment producing defects in the Al2O3 layer. The defects produced partially relaxed. The rate of relaxation is, however, different in the surrounding of the interface and in the "bulk" parts of the Al2O3 layer. This difference generates an oxygen concentration gradient and consequently oxygen diffusion, resulting in an altered layer which grows from the Al2O3 / Si substrate interface. The relative rate of the diffusion and relaxation is strongly temperature dependent, resulting in various altered layer compositions, SiO2 (at room temperature), Al2O3 + AlOx+Si (at 500o C), Si(at 700o C), as the temperature during irradiation varies. Utilizing this finding it is possible to make area selective interface patterning.
The adaptive function of sexual reproduction: resampling the pool of genotypic possibilities.
Authors: Hickey Donal , Golding Brian
Published: February 2021

BackgroundNatural populations harbor significant levels of genetic variability. Because of this standing genetic variation, the number of possible genotypic combinations is many orders of magnitude greater than the population size. This means that any given population contains only a tiny fraction of all possible genotypic combinations.ResultsWe show that recombination allows a finite population to resample the genotype pool, i.e., the universe of all possible genotypic combinations. Recombination, in combination with natural selection, enables an evolving sexual population to replace existing genotypes with new, higher-fitness genotypic combinations that did not previously exist in the population. Gradually the selected sexual population approaches a state where the optimum genotype is produced by recombination and where it rises to fixation. In contrast to this, an asexual population is limited to selection among existing lower fitness genotypes.ConclusionsThe significance of the result is two-fold. First, it provides an explanation for the ubiquity of sexual reproduction in evolving populations. Secondly, it shows that recombination serves to remove concerns about the cost of natural selection acting on the naturally occurring standing genetic variation. This means that classic population genetics theory is applicable to ecological studies of natural selection acting on standing genetic variation.
An Efficient and High Accuracy P300 Detection for Brain Computer Interface System Based on Kernel Principal Component Analysis
Authors: Hashmi Mohammad Farukh Hashmi Mohammad Farukh , D.Kene Jagdish D.Kene Jagdish , M.Kotambkar Deepali M.Kotambkar Deepali , Matte Praveen Matte Praveen , G.Keskar Avinash G.Keskar Avinash
Published: February 2021

Human machine interaction with the use of brain signals has been made possible by the advent of the technology popularly known as brain computer interface (BCI). P300 is one such brain signal which is used in many BCI systems. The problems associated with most of the existing P300 detection methods are that they are time consuming and computationally complex as they follow the procedure of averaging the values obtained from multiple trials. Also the existing single trial methods have been able to obtain only moderate accuracy levels. In this paper, a novel approach which for achieving a high level of accuracy has been proposed for single trial P300 signal detection amidst noise and artifacts. In this method features were obtained by applying Discrete Wavelet Transform followed by a technique making use of the obtained wavelet coefficients. Kernel Principal Component Analysis (KPCA) was used for reducing the feature dimension. Classification of the P300 signal using the reduced features was done using Support Vector Machine (SVM). The Dataset used was the Dataset II of the third BCI Competition. An accuracy of 98.53% was achieved for Subject S1 (signal obtained from the first person) and 99.25% for Subject S2 (signal obtained from the second person) by using the proposed method. A high level of accuracy was obtained, as compared to many existing techniques. Also the speed of classification was improved with the use of reduced feature dimensions.
Design, Simulation and Fabrication of an Implanted Antenna at ISM Band in Body Tissue
Authors: Seydi Majedeh , Bayati Mohammad Sajjad
Published: February 2021

A rectangular meandering-microstrip patch antenna (RM-MPA) with shorting pin for implant antenna and biomedical applications at industrial, scientific, and medical (ISM) band is proposed. The rectangular patch has length of l =14 mm and width of w =9.4 mm. The substrate and superstrate are made of Rogers 3210 with dielectric constant equals 10.2. The RMMPA is placed between the substrate and superstrate dielectric layers whose same thickness equals 0.635 mm. The proposed antenna is fed by a 50-ohm coaxial probe, at the centre of the length and edge of the width of the patch. The input impedance of patch antenna varies with the patch geometry. Thus, the geometry of the patch changed to achieve impedance matching at ISM band. The rectangular patch divided to three sections along width for meandering. The resonance frequency is tuned by meandering each section. The proposed antenna is simulated in free space and skin phantom. Proposed antenna has efficiency of 90%, bandwidth 1.02%. Both radiation pattern and SAR are evaluated which SAR level is below the safety and satisfies SAR standards. Finally, the antenna is tested in minced meat and tissue liquid.
Relationship Between Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease in the Non-Obese Chinese Population: A Secondary Analysis Based on A Cross-Sectional Study
Authors: Gao Shengqiang , Ramen Kuvaneshan , Yu Shian , Luo Jiansheng
Published: February 2021

Background: Non-alcoholic fatty liver disease (NAFLD) is linked to some metabolic disorders. Herein, we explored the relationship of levels of serum uric acid （SUA）with NAFLD in a population of non-obese Chinese. Methods: This was a cross-sectional study that involved 183,903 Chinese men and women with an average age of 40.98 years who underwent physical examinations at a health screening center at Wenzhou People’s Hospital. We defined NAFLD by ultrasound detection of steatosis. We employed univariate analysis along with multivariate Cox proportional hazards analyses to investigate the relationship of SUA level with NAFLD. Moreover, we employed the receiver operating characteristic curve to establish the SUA cutoffs of estimating NAFLD. Results: Overall, 25,501 participants (13.9%) had NAFLD. The NAFLD ORs were 1.47 (95% CI 1.35 to 1.59), 2.01 (95% CI 1.85 to 2.18) and 2.77 (95% CI 2.55 to 3.02) compared with Q1.AUC values for SUA ratios was 0.728. The optimal SUA level cut-off value for identification of NAFLD was 287.5, with a specificity and a sensitivity of 60.7% and 73.9%, respectively.Conclusion: High Serum uric acid levels shows positive correlation with NAFLD. SUA constitutes a cheap, simple, non-invasive, as well as a beneficial biomarker that could be utilized to forecast NAFLD in the non-obese Chinese population.
Application of beet sugar byproducts improves sugar beet biofortification in saline soils and reduces sugar losses in beet sugar processing
Authors: Alotaibi Fahad , Bamagoos Atif A. , Ismaeil Fekry M. , Zhang Wenying , Abou-Elwafa Salah Fatouh
Published: February 2021

Improving the chemical and physical properties of saline soils is crucial for the sustainable production of sugar beet and efficient processing of beet sugar. Here, the impacts of the application of treated filter cake on sugar beet biofortification under saline soil and sugar losses into molasses during beet sugar processing were evaluated for the first time.
The application of treated filter cake significantly reduced K%, Na% and α-amino-N while enhanced sucrose content and quality index of beet root juice. Consequently, sugar loss percentage, sugar loss yield and relative sugar loss yield were reduced, whereas recoverable sugar yield was enhanced. Linear regression analysis revealed that quality index and sugar loss yield were increased, whereas sugar loss percentage and relative sugar loss yield were reduced in response to the reduction of soil Na + content accompanied with increasing Ca 2+ content in the soil increased. The results provide treated filter cake as a promising amendment for saline soils remediation for improving biofortification of sugar beet and reducing sugar losses during beet sugar processing.
Temporal variation revealed the composition change of phytoplankton assemblage responds to varied environmental indicators within an artificial freshwater engineered ecosystem
Authors: Xu Duo , Wang Hao , Chen Aiting , Xu Runyu , Niu Yunxia
Published: February 2021

Artificial freshwater engineering ecosystems (AFwEEs) have attracted more and more attention. Phytoplankton is critical to the fluctuation of water quality in the AFwEEs. However, there is still a major knowledge gap regarding the ecology, composition, and temporal dynamics of phytoplankton assemblage composition in AFwEEs. Hence, an AFwEEs designed base on the submerged macrophytes (i.e., Vallisneria natans, Najas marina, and Potamogeton crispus) and fishes (i.e., Hypophthalmichthys molitrix, Hypophthalmichthys nobilis, and Ctenopharyngodon idellus) was established. The initial purpose for this survey was to conduct almost entire year (April/2019 – December/2019) sampling investigation to explain the interactions and relationship between multifarious environmental indicators and phytoplankton, also for the different phenomenon explanation of composition change in phytoplankton assemblage between AFwEEs and natural water environments. Consequences exhibited the assemblage dynamics of the phytoplankton were significant varied with seasonal succession, in which Cyanophyta dominated the phytoplankton assemblage while the mean relative abundance accounted for 66.4%, and then was Chlorophyta, for 18.8%. Principal component analysis (PCA) demonstrated temporal variation was significant impacted on phytoplankton assemblages. The dominant species, different assemblages, and distribution of phytoplankton were closely related to the dynamic changes of seasonal succession, which might change the composition of phytoplankton assemblage in the FwAEEs. Results of redundancy analysis (RDA) revealed the water temperature, nutrient concentration, DO concentration, and pH value were the main abiotic environmental indicators affecting phytoplankton assemblage. The trend of the four diversity indices indicated the phytoplankton assemblage became more stable in winter while the change extent of that was more significant in summer.
Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects
Authors: Ni Xuejun , Shan Xiuying , Xu Lili , Yu Wenjun , Zhang Mingliang , Lei Chen , Xu Nating , Lin Junyu , Wang Biao
Published: February 2021

Background: Wound healing is impaired in patients with diabetes due to the multifactorial etiology of the disease, which limits the therapeutic efficacy of various approaches. This study hypothesizes that the combination of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) might achieve optimally efficient diabetic wound healing.Methods: ADSCs were isolated from the adipose tissues of Sprague-Dawley (SD) rats. PRP was prepared by using a two-step centrifugation technique. A diabetic wound model was established on the backs of SD rats to evaluate the effect of ADSCs incorporated into PRP. Hematoxylin and eosin staining, immunofluorescence and immunohistochemistry were performed to observe the changes in neovascularization. ELISA and Western blot were utilized to detect the angiogenesis-related protein expression levels. The proliferation of endothelial cells was assessed by the MTS assay.Results: ADSCs incorporated into PRP induced a higher wound closure rate than ADSCs, PRP and negative control. The expression levels of VEGF, p-STAT3 and SDF-1 in the ADSC-PRP group were higher than those in the other groups. Moreover, the proliferation of endothelial cells was strongly stimulated by treatment with the combination of ADSC-conditioned medium (ADSC-CM) and PRP.Conclusions: PRP enhanced diabetic wound healing induced by ADSCs, and its promoting effect involved neovascularization.
Transcapillary escape rate of 125I-albumin in relation to timing of blood sampling: the need for standardization.
Authors: Chahid Youssef , Rorije Nienke , Boujoufi Soufian el , Mathôt Ron , Vogt Liffert , Verberne Hein
Published: February 2021

Background Increased vascular permeability is an early sign of vascular damage and can be measured with the transcapillary escape rate of albumin (TERalb). Although TERalb has a multi-exponential kinetic model, most published TERalb data are based on mono-exponential kinetic models with variation in blood sampling schemes. Aim of this posthoc study was to evaluate the influence of variation in blood sampling schemes and the impact of mono- or bi-exponential analyses on the calculation of TERalb. Study participants were part of a cross-over intervention study protocol, investigating effects of sodium loading on blood pressure, endothelial surface layer and microcirculation. Multiple blood samples were drawn between 3 and 60 minutes after injection of radioactive iodide labeled human serum albumin (rHSA). Results In total 27 male participants with 54 measurements were included. For all participants the maximum serum radioactivity was reached within 20 minutes, while 85% of the participants had their maximum serum activity within 10 min. The TERalb calculated with the subsequently chosen T20 – 60 min reference scheme (6.19 ± 0.49%/h) was significantly lower compared to the TERalb of the T3 – 60 min, T5 – 60 min, and Tmax – 60 min schemes. There was no significant difference between the T20 – 60 min reference scheme and the T10 – 60 min and T15 – 60 min schemes. Bi-exponential kinetic modeling did not result in significant different observations compared to the mono-exponential kinetic analysis.Conclusions As there is variation in the timing of the maximum serum radioactivity of rHSA, blood sampling schemes starting before 10 minutes after administration of rHSA will result in a significant overestimation of TERalb. In addition, variation in kinetic modeling did not result in significant changes in TERalb. Therefore, we emphasize the need to standardize TERalb and for practical and logistical reasons advocate the use of a mono-exponential model with blood sampling starting 20 minutes after rHSA administration.
Human and Technology in the Animation Industry
Authors: Limano Ferric
Published: February 2021

Humanism is a term in intellectual history that is often used in the fields of philosophy, education and literature. In classical greek times, this humanism manifested itself in paideia, a classical greek education system that was intended to translate the vision of the ideal human being. However, this classical Greek perspective departs from a purely natural view of humans. So, humans and education are like two sides of a coin that cannot be divorced. Technology is also the result of educated human beings, technology holds many beautiful promises, but in the experience and history of technology also contains threats and dangers contained in it. In this study, how to discuss the history and development of the Indonesian animation industry, from a human and technological perspective. The result of this research is to provide a viewpoint of thinking in the animation industry that humans and technology can coordinate together, resulting in many animation actors who maximize potential in animation technology.
Cumplicidade e impunidade: uma análise pós-colonial do envolvimento do setor bancário na corrupção transnacional
Authors: Nascimento Isabella Chaves , Oliveira Cintia Rodrigues de
Published: February 2021

Esta pesquisa aborda a corrupção, reconhecendo a importância das redes transnacionais informais na perpetuação da corrupção. O objetivo geral é compreender, sob a lente pós-colonial, como a corrupção se constitui um fenômeno transnacional. Realizamos uma pesquisa qualitativa, com a análise de documentos sobre casos de corrupção envolvendo um grande banco internacional: o HSBC Holdings Plc. O material empírico foi extraído da organização International Consortium of Investigative Journalists (ICIJ) e do jornal britânico The Guardian, sendo submetido à análise temática. O mapa temático final destaca dois temas que desvelam as relações coloniais: a cumplicidade dos agentes do sistema financeiro com os infratores e a impunidade do colonizador com esses mesmos agentes. Os resultados apontam para um padrão histórico de leniência e conivência do banco com criminosos, com diversos processos acusatórios encerrados com acordos, resumidos às multas que, por maiores que fossem em relação às práticas da justiça até então, não representavam sanções que inibissem as eventuais reincidências.
Rzecznik finansowy i jego rola w systemie ochrony klienta rynku usług finansowych
Authors: Grabowski Jędrzej
Published: February 2021

Artykuł stanowi próbę subiektywnej oceny działalności Rzecznika Finansowego. Celem artykułu jest analiza oraz omówienie tematyki realizacji zadań Rzecznika Finansowego w oparciu o sprawozdania z działalności Rzecznika Finansowego, orzecznictwo Sądu Najwyższego, Trybunału Sprawiedliwości Unii Europejskiej oraz opracowania doktryny.
The Issue Of Christian Anthropology
Authors: Kuc Leszek
Published: February 2021

2e text of Gaudium et spes has not yet become the basis for a systematic analysisfrom the point of view of Christian anthropology+>. We shall not conducta systematic analysis at the end of this article. We will only mention a fewissues that are particularly important in our opinion. 2e first issue is the veryarrangement of the first chapter of the Constitutions. It speaks firstly of thedignity of the individual, then of the human community, and only then does itmove on to the discussion of human activity in the world and the tasks of theChurch in the modern world. 2e anthropological concept of the text can beseen from the very layout of the chapters of the first part.2e idea is that the concept of the presence of the Church in the contemporaryworld, that is, the concept of the Church as a sign, that is, a modern conceptof pastoral ministry with the whole Church as a subject, depends on the rightattitude and resolution of the question of who I am and who I – man – become.2is is the basic premise of an anthropological structure, expressed in questionsabout the dignity of the person and the human community.
Anthropology of Psalm 8
Authors: Grzybek Stanisław
Published: February 2021

Anthropology of Psalm 8
“For Christ Is the End of the Law” (Rom 10:4). Topicality of Religious-Moral Principles of the Old Testament
Authors: Muszyński Henryk
Published: February 2021

“For Christ Is the End of the Law” (Rom 10:4). Topicality of Religious-Moral Principles of the Old Testament
From Reistic to Personalist Theology
Authors: Bartnik Czesław
Published: February 2021

From Reistic to Personalist Theology.
Avaliação da produção de biogás obtido a partir de dejeto bovino e casca de café
Authors: Ferrari Fumian Verônica Aparecida , da Silva Picanço Tayná , Fonseca Porto Luís Paulo , Bandoli Gomes Camila de Paula , Ferrarez Adriano Henrique
Published: February 2021

A bovinocultura e a cafeicultura possuem uma grande participação no Produto Interno Bruto (PIB) brasileiro. Essas atividades, entretanto, produzem grande quantidade de resíduos que causam grandes impactos ambientais. A digestão anaeróbica se apresenta como solução no gerenciamento desses resíduos, resultando na produção de biogás e biofertilizante. O objetivo deste trabalho foi avaliar a produção e o teor de metano (CH4) do biogás obtido a partir de dejeto bovino e casca de café. Utilizou-se duas triplicatas de digestores de bancada, a saber: (i) D1 – dejeto bovino (1 Litro); e (ii) D2 – dejeto bovino e casca de café (1 Litro: 1 Litro). Semanalmente foram realizadas as medições do volume e do teor de metano (CH4) do biogás produzido. Ao final do experimento foi realizada a medição do pH do material remanescente em cada digestor anaeróbico. Observou-se que a triplicata D2 apresentou produção acumulada de biogás com teores médios de CH4 maiores que a triplicata D1. O pH se apresentou na faixa ótima para o processo anaeróbico em todos os digestores.
Nuevos registros de especies y un hospedero vegetal del género Heilipus Germar (Curculionidae: Molytinae: Hylobiini) para Colombia
Authors: Díaz Valentina , Equihua-Martínez Armando , Romero-Nápoles Jesús , Valdez-Carrasco Jorge , Vallejo-Espinosa Luis Fernando
Published: February 2021

Heilipus Germar, 1824 es un género de curculiónidos con distribución en el continente americano. Actualmente está conformado por 88 especies, algunas de las cuales son consideradas plaga en cultivos con alto valor comercial como el aguacate (Persea americana Mill.) y la guanábana (Annona muricata L.). A pesar de su importancia, el género ha sido poco estudiado y sólo se conocen los hábitos y plantas hospederas de 12 especies. En Colombia, la información sobre este grupo es igualmente escasa y el listado más reciente data de 1986, el cual reporta 15 especies. Con el objetivo de actualizar el conocimiento sobre las especies de Heilipus presentes en Colombia, se visitaron diez museos y colecciones entomológicas del país en busca de ejemplares del género. Durante la visita a las colecciones se encontraron especímenes de H. discoides (Fabricius), H. draco (Fabricius), H. empiricus (Pascoe), H. guttiger (Champion), H. longirostris (Champion), H. osculatii Guérin y H. tetanicus (Pascoe), los cuales constituyen nuevos registros para el país. Con estos resultados, el número de especies de Heilipus presentes en Colombia asciende a 23, cifra que posiciona al país como el segundo con mayor diversidad del grupo después de Brasil. Se destaca el hallazgo del hospedero vegetal y la identificación del hábito de H. longirostris, especie que en su estado larval barrena semillas de Aniba sp. Probablemente el número de especies de Heilipus presentes en Colombia sea más alto; sin embargo, la ausencia de una clave de identificación y la falta de una revisión formal del grupo dificultan la determinación de especies, tanto las ya descritas como aquellas que pueden ser nuevas para la ciencia.
Human Evolution
Authors: Lane Jan-Erik
Published: February 2021

R. Dawkins claims success for selfish machines that room the animal kingdom. Animals have optimal genes selection. Turning from advanced biology to the humanities and social sciences, can we distil a few evolutionary lessons?
Knowledge◦Room exploring social justice by going beyond ‘traditional’ spaces and activities of science centres
Authors: Habibi Doroh Hessam , Streicher Barbara
Published: February 2021

This article describes an example of science engagement striving for social justice by invigorating neglected spaces. The pop-up science centre “Knowledge◦Room“ in Vienna encourages learning, participation and engagement and provides accessibility to different groups regardless of their background. Based on a case-study of a bottom-up event at the Knowledge◦Room, we show how science communication can create a trust-based connection with disadvantaged groups in society and inspire their curiosity in science. We argue that science communication can be used as a tool for advancing social justice in the wider sense and facilitate encounters between diverse groups within society.
Queer world-making: a need for integrated intersectionality in science communication
Authors: Roberson Tara , Orthia Lindy A.
Published: February 2021

This commentary aims to shed light on the neglected space of queer people in science communication. In this piece, we introduce queer theory to science communication literature to examine issues from the past, present, and future. We argue that to queer our field may entail a radical interrogation of some of science communication's deeply rooted cultural traits and working towards a rainbow-tinted future.
Community engagement and co-creation of strategic health and environmental communication: collaborative storytelling and game-building
Authors: Villar Maria Elena
Published: February 2021

From a strategic communication perspective, for any communication to be effective, it must be audience-centered, with content and delivery channels that are relevant to its intended target. When trying to reach culturally specific communities or other groups that are not otherwise connected with science research, it is crucial to partner with community members to co-create content through media that is appealing and culturally competent. This commentary considers some examples including storytelling through ‘fotonovelas’ and radio stories, community drama and serious games.
Implementasi Keteladanan Rasulullah Saw Berdasarkan Al-Qur’an Surat Al-Ahzab Ayat 21 Bagi Pendidik Era Milenial
Authors: Nurdin Nurdin
Published: February 2021

Today's problems are the lack of study and enthusiasm of millennial teachers to implement the lead by example of the Prophet Muhammad as stated in Al-Qur'an Al-Ahzab verse 21. Even though the Prophet was a figure of uswatun hasanah as a human guided to be used as a reference for millennial educators in implementing the value of education in his life. The purpose of this study was to find out the value of education in Al-Qur'an Al-Ahzab verse 21 and to find out how to implement based on Al-Qur'an surah al-ahzab verse 21 for millennial educators. The method of data collection is a literature study of Al-Qur'an verses with a library research approach. The conclusions in this discussion are several ways that millennial teachers can implement the values through Surat al-Ahzab verse 21, among others: the implementation of the sidiq character of the messenger in the real context of being honest with oneself which begins with small things to the big, implementation of the nature of trust by practicing the values ​​of the teacher educating with all his heart, Implementation of the nature of tabligh by conveying the truth even though it is bitter, the implementation of fathanah by learning to hone his skills, develop his education so motivated students, improve quality comprehensive education and improving language skills so that students follow in the footsteps of their teachers.
ASUPAN ZINK DAN TINGKAT KECERDASAN ANAK SEKOLAH DASAR DI KOTA KUPANG, NUSA TENGGARA TIMUR
Authors: Sanjiwani Putu Amrytha , Shinta Dewi , Fahmida Umi
Published: February 2021

Latar Belakang. Permasalahan gizi merupakan permasalahan serius yang dapat berdampak pada perkembangan kognitif dan motorik, serta prestasi akademik terutama pada usia sekolah. Kognitif merupakan interaksi antara faktor bawaan dan faktor lingkungan. Zink merupakan salah satu mineral mikro yang berkontribusi terhadap fungsi kecerdasan. Kekurangan zink akan berdampak pada perkembangan kecerdasan melalui perubahan perhatian, aktivitas, perilaku neuropsikologikal, dan perkembangan motorik. Tujuan. Penelitian ini dilakukan untuk menganalisis hubungan antara asupan zink dengan tingkat kecerdasan anak sekolah dasar di Kota Kupang. Metode. Penelitian ini merupakan penelitian kuantitatif dengan rancangan cross-sectional. Penelitian dilakukan pada anak di 12 sekolah dasar di 6 kecamatan se-Kota Kupang. Data tingkat kecerdasan anak dikumpulkan oleh 3 orang psikolog dengan menggunakan metode Wechsler Intellegence Scale for Children: Second Edition (WISC-II). Data asupan zink dalam penelitian ini dikumpulkan oleh enumerator dengan metode food recall 24 jam selama 3 hari yang meliputi hari sekolah dan hari libur. Tes distribusi normal dilakukan untuk variabel kontinyu menggunakan Kolmogorov-Smirnov test. Uji korelasi untuk melihat hubungan antara asupan zink dengan tingkat kecerdasan menggunakan uji Spearman. Hasil. Proporsi kurus dalam penelitian ini adalah 23,9 persen dan asupan rata-rata zink adalah 3,79 mg/hari dan masih belum mencukupi kebutuhan yang dianjurkan. Hasil uji Spearman Rho ditemukan adanya korelasi positif yang signifikan antara asupan zink dengan tingkat kecerdasan anak (r=0,17; p=0,006). Pada hasil uji regresi linier ditemukan faktor yang paling berhubungan dengan skor kecerdasan adalah jenis kelamin (p=0,016), dan tidak terdapat hubungan antara asupan zink dengan kecerdasan anak. Penelitian ini menemukan anak perempuan memiliki tingkat kecerdasan 4 poin lebih tinggi dibandingkan anak laki-laki. Kesimpulan. Asupan zink dari makanan tidak berhubungan dengan tingkat kecerdasan anak, tetapi jenis kelamin merupakan faktor dominan tingkat kecerdasan anak.
O MERCADO DE TRABALHO PARA O PROFISSIONAL DE EDUCAÇÃO FÍSICA NO ESTADO DO PARANÁ – BRASIL
Authors: Fonseca Rubiane Giovani , Both Jorge
Published: February 2021

O objetivo do trabalho foi analisar as características dos profissionais de Educação Física com vínculos formais de emprego no estado do Paraná considerando um período de dez anos. Os dados empregados no estudo foram extraídos da Relação Anual de Informações Sociais (RAIS) dos anos de 2007 e 2017, disponibilizada pelo governo federal brasileiro, para analisar descritivamente informações sobre faixa etária, gênero e remuneração nas diferentes ocupações laborais. Os resultados revelaram que ocorreu a diminuição dos vínculos formais de emprego na faixa etária de 40 a 49, mas a faixa etária de 50 anos ou mais apresentou acréscimo. Quando observados os setores de atuação, constatou-se que as mulheres eram a minoria nos postos de emprego. Os postos de atuação menos valorizados em relação à remuneração representaram mais de 60% dos profissionais inseridos formalmente no mercado de trabalho.