bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticancer Effect and Phytochemical Profile of the Extract from Achillea ketenoglui
against Human Colorectal Cancer Cell Lines
Authors: Ayan İlknur Ç. , Çetinkaya Sümeyra , Dursun Hatice G. , Güneş Canan E. , Şirin Seda
Published: September 2021

Background:

In the treatment of Colorectal Cancer (CRC), the search for new antineoplastic drugs with
fewer side effects and more effectiveness continues. A significant part of these pursuits and efforts focus on medicinal
herbs and plant components derived from these plants. A. ketenoglui is one of these medicinal plants, and its anticancer
potential has never been studied before.

Methods:

The phenolic and flavonoid content, and antioxidant activity of A. ketenoglui extracts were determined. The
phytochemical profiling and quantification analysis of major components were performed by HPLC-ESI-Q-TOF-MS.
Cytotoxicity, proliferation, apoptosis and cell cycle were evaluated to reveal the anticancer activity of the extract on
CRC cells (HCT 116 and HT-29). The determined anticancer activity was confirmed by mRNA (RT-qPCR) and protein
(Western blotting) analyzes.

Results:

A. ketenoglui methanol extract was found to have high phenolic (281.89±0.23) and flavonoid (33.80±0.15)
content and antioxidant activity (IC50 40.03±0.38). According to the XTT assay, the extract has strong cytotoxic activity
(IC50 350 μM in HCT 116 and IC50 263 μM in HT-29 cell line). The compounds most commonly found in the plant
are, in descending order, chlorogenic acid, apigenin, genistin, baicalin, eupatorin, casticin, and luteolin. In flowcytometric
analysis, the extract was found to induce greater apoptosis and cell cycle arrest in both cell lines than in both
control and positive control (casticin). According to the results of the mRNA expression analysis, the extract treatment
upregulated the expression of the critical genes of the cell cycle and apoptosis, such as p53, p21, caspase-3, and
caspase-9. In protein expression analysis, an increase in caspase-3 and p53 expression was observed in both cell lines
treated with the extract. In addition, caspase-9 expression was increased in HT-29 cells.

Conclusion:

The findings show that A. ketenoglui has an anticancer potential by inducing apoptosis and arresting the
cancer cell cycle and may be promising for CRC therapy. This potential of the plant is realized through the synergistic
effects of its newly identified components.
Thyroid Function: A Target for Endocrine Disruptors, Air Pollution and Radiofrequencies
Authors: Di Ciaula Agostino , Bonfrate Leonilde , Noviello Marica , Portincasa Piero
Published: September 2021

Thyroid diseases, including congenital hypothyroidism, thyroiditis, and childhood thyrotoxicosis, are progressively increasing. The incidence of thyroid cancer in children and adolescents has also increased in recent decades, mirroring the trends observed in adults. These epidemiologic trends develop in parallel with the rising costs associated with diagnosis and treatment of thyroid diseases. Both genetic and environmental factors are involved in these diseases, and a number of widely diffused toxic chemicals of anthropogenic origin can impair thyroid function and make thyroid cancer worse. Synthetic substances persistently contaminate environmental matrices (i.e., air, soil, water) and the food chain and bio-accumulate in humans, starting from in utero life. Environmental toxins such as air pollutants, endocrine disruptors, and high-frequency electromagnetic fields can act on common targets through common pathways, combined mechanisms, and with trans-generational effects, all of which contribute to thyroid damage. Both experimental and epidemiologic observations show that mechanisms of damage include: modulation of synthesis; transportation and metabolism of thyroid hormones; direct interference with hormone receptors: modulation of gene expression; and autoimmunity. We should not underestimate the available evidence linking environmental pollutants with thyroid disease, cancer included, since toxic substances increasingly diffuse and thyroid hormones play a key role in maintaining systemic metabolic homeostasis during body development. Thus, primary prevention measures are urgently needed in particular to protect children, the most exposed and vulnerable subjects.
Nitric Oxide Modulation as a Potential Molecular Mechanism Underlying
the Protective Role of NaHS in Liver Ischemia Reperfusion Injury
Authors: Ibrahim Salwa A. , Abdel-Gaber Seham A. , Ibrahim Mohamed A. , Amin Entesar F. , Mohammed Rehab K. , Abdelrahman Aly M.
Published: September 2021

Background and aim:

Liver IR is a frequent clinical complication with high morbidity
and mortality. The present study evaluated the possible protective effect of sodium hydrosulfide
(NaHS), a H2S donor, in IR-induced hepatic injury and explored the mechanisms of actions of the
investigated drug.

Methods:

Male albino rats (200-230 g) were divided into the following groups: group 1:Sham-operated
non treated rats, group 2: IR non treated rats, group 3: L-NNA + IR rats, group 4: NaHS + IR
rats, group 5: L-NNA + NaHS + IR rats. Blood samples were collected for ALT determination. Liver
tissue samples were used for the assessment of GPx, catalase, SOD, MDA, total nitrites and TNF-
α. Parts from the liver were fixed in 10% formalin solution for histopathological examination
and immunohistochemical examination of iNOS, eNOS and caspase-3.

Results:

NaHS protected the liver against IR. This hepatoprotection was associated with normalization
of antioxidant enzyme activity and decrease in hepatic MDA, TNF-α and expression of caspase-
3 and iNOS.

Conclusion:

NaHS is hepatoprotective in IR injury. The hepatoprotective effects of NaHS are associated
with antioxidant, anti-inflammatory and antiapoptotic effects. These effects are probably mediated
via NO modulation.
In-Silico Analysis of rSNPs in miRNA:mRNA Duplex Involved in Insulin
Signaling Genes Shows a Possible Pathogenesis of Insulin Resistance
Authors: Sunny Jithin S. , Saleena Lilly M.
Published: September 2021

Background:

Insulin resistance is a condition in which the body produces insulin but is
unable to use it effectively. Aberrations in insulin signaling are known to play a crucial role in the
pathogenesis of this disease state. Eventually, patients will have glucose build-up in their blood instead
of being absorbed by the cells, leading to type 2 diabetes.

Objective:

In the current study, we focus on understanding the role of rSNP mediated miRNA:mRNA
dysregulation and its impact on the above metabolic condition.

Methods:

More than 30 genes involved in the insulin signaling pathway were found using the
KEGG database. The 3’UTR end of genes was studied by using RegRNA and Ensembl, whereas
TargetScan along with miRbase were used to identify their target miRNAs. Binding free energy
was used as a parameter to analyze the effect of polymorphism on the miRNA:mRNA duplex formation.
Further, the UNA fold was used to determine the heat capacity changes.

Results:

The genes INSR, INS, GLUT4, FOXO1, IL6, TRIB3, and SREBF1, were selected for
analysis. Multiple miRNAs, hsa-miR-16-5p, hsa-miR-15a-15p were identified in the SNP occurring
region for INSR. INS, too, showed similar results. INSR, INS, and TRIB3 were found to have
the maximum change in their binding free energy due to rSNP variation. A destabilisation in the
heat capacity values was observed too, which contributed due to rSNP induction.

Conclusion:

A direct relationship between miRNA target polymorphism and the stability of the
miRNA:mRNA duplex was observed. The current methodology used to study insulin resistance
pathogenesis could elaborate on our existing knowledge of miRNA-mediated disease states.
Regeneration Potential of Bone Marrow-derived Mesenchymal Stromal
Cells Lysate for H2O2 (In-Vitro) Injured Cells
Authors: Malik Sabeen , Awan Sana Javaid , Hashim Mariam , Farzand Anam , Nadeem Shumaila
Published: September 2021

Background:

Mesenchymal stromal cells (MSCs) and their paracrine factors make them
a suitable cell-free-therapeutic candidate. Cellular lysate usage could be an effective treatment strategy
that circumvents the possible associated drawbacks of stem cell therapies.

Objective:

Thus, this research aims to examine the injury regeneration potential of MSCs cellular
lysate derived from bone marrow by studying its anti-apoptotic, proliferative, and anti-oxidative effects.

Methods:

Hydrogen peroxide (H2O2) was used to induce cellular injury. MTT assay, trypan blue,
and crystal violet assays were used to assess bone marrow-derived mesenchymal stromal cell (BMSCs)
lysate treated cells' viabilities. Next, to investigate the BMSCs lysate anti-oxidative potential
anti-oxidants, ascorbate peroxidase (APX), glutathione reductase (GR), and superoxide dismutase
(SOD) assays were performed. Simultaneously, the proliferative and anti-apoptotic potential was
measured via vascular endothelial growth factor (VEGF A) and p53 expression analysis through
immunostaining and ELISA.

Results:

It was observed that BMSCs lysate enhances the viability of H2O2 injured cells. APX, GR,
and SOD's results indicated that after H2O2 injury, the anti-oxidant status decreased significantly
and was uplifted by BMSCs lysate treatment. Additionally, the results of p53, BAX, and caspase-3
expression revealed that BMSCs lysate inhibits apoptosis by downregulating their expression in
treated cells. The VEGF protein expression findings demonstrated that BMSCs lysate upregulates
the downregulated expression of VEGF in H2O2 injured cells. The expression of proliferative markers
(TOP2A, PCNA, and Ki-67) was also elevated in BMSCs treated cells.

Conclusion:

To conclude this study's findings, it was observed that BMSCs lysate could decrease
H2O2 injury and possibly regenerate the injured cells by enhancing their viability and proliferation,
improving anti-oxidants levels, and alleviating apoptosis.
Local adaptation of invasive plant, Synedrella nodiflora, in urban tropical lowland landscape Universitas Indonesia
Authors: Maryanto Andi Eko , Salamah Andi , Windarti Citra Karina , Syadewi Mutia
Published: September 2021

Synedrella nodiflora is an invasive species originated from tropical America and now has spread throughout Indonesia. We analysed the ability of Synedrella nodiflora from the level of HSP70 gene expression at different heat stress in urban tropical lowland landscape Universitas Indonesia.  We used the qPCR to quantify the level of HSP70 gene expression and analysed using Pfaffl model. We found the level of HSP70 gene expression got higher related to elevated temperature from 29oC to 39oC with a range of fold from 123.1 to 1676.9. This ability reflects the adaptive plasticity of Synedrella nodiflora in the course of the invasion process.
AMELIORATIVE ROLE OF GARLIC (ALLIUM SATIVUM) ON CHROMIUM (VI) - INDUCED MEMBRANE DAMAGE IN MALE ALBINO RATS
Authors: SOUMITA DEY  , SANKAR KUMAR DEY
Published: September 2021

Objective: Membrane damage is one of the important consequences of chromium (Cr) induced cytotoxicity. Garlic possesses antioxidant property to scavenge the toxic radicals and cytoprotective activity. The aim of the present study is to evaluate the ameliorative role of aqueous extract of garlic (AEG) on Cr-induced membrane damage of both liver and kidneys in male albino rats.

Methods: Male albino rats of Wistar strain (80-100 g) were used for the present study. Rats were divided into three groups of almost equal average body weight. The animals of two groups were injected K2Cr2O7 at a dose of 0.8 mg per 100 g body weight per day for 28 days. The animals of one of the Cr-treated groups served as the supplemented group supplied aqueous extract of garlic (AEG) (250 mg per kg body weight daily at an interval of 6 h after injection of Cr for a period of 28 days). The animals of the remaining group received only the vehicle (0.9% NaCl), served as control. The body weights of the animals were taken in each day of treatment schedule.

Results: The results indicated that significant increases in membrane cholesterol level as well as significant decreases in membrane phospholipid level in Cr exposed animals suggest structural alterations in both liver and kidneys plasma membrane. Alkaline phosphatase (ALP), total ATPase, and Na+-K+- ATPase activities of plasma membrane were significantly decreased in both liver and kidneys after Cr treatment. On the other hand, AEG supplementation plays a vital role to restore such alterations induced by Cr in plasma membrane of both liver and kidney.

Conclusion: These findings indicate that Cr treatment at the present dose and duration induces structural and functional alterations in the plasma membrane in both liver and kidney. However, AEG supplementation restored those alterations induced by Cr in plasma membrane of both liver and kidneys but was not able to eliminate the deposited Cr from the liver and kidney tissues.
THE IMPACT OF MEDICATION REGIMEN COMPLEXITY ON ADHERENCE TO LONG-TERM THERAPIES
Authors: MIR SHAKEEL AHMAD , SHAKEEL DANISH
Published: September 2021

Objective: Adherence is a multifactorial phenomenon. Medication-related factors have long been the focus of attention. However, the results are inconsistent.
Methods: In a cross-sectional questionnaire-based study of outpatients, we assessed 180 patients suffering from chronic conditions. The objective of this study is to determine the impact of medication regimen complexity on adherence to long-term drug therapies.
Results: 91.66% of patients receiving more than four drugs had good or high adherence. 80.94% of patients on thrice a day (or more) drug administration had good or high adherence. 91.66% of patients receiving drug therapy for more than 5 years had good or high adherence. In all other groups, the adherence was low. The adherence was significantly (p<0.05) and positively (rs=0.792 and 0.846) correlated to the frequency of drug administration and duration of treatment. Adherence was positively correlated to the number of drugs per day (rs=0.668) but the relationships were not statistically significant (p=0.102). All the correlations were large.
Conclusions: We found adherence positively correlated with medication regimen complexity. An improved understanding of the determinants of medication adherence is needed.
Keywords: Medication regimen complexity, Adherence, Long-term therapy, Chronic disease
A RETROSPECTIVE STUDY ON PREVALANCE OF ANEMIA IN PREGNANCY IN A TERITIARY CARE HOSPITAL
Authors: KUBRA HUSSAINI SYEDA ZAINEB , SHEREEN BUSHRA , D SIRISHA , E MADHAVI , E HARI PRIYA , G HIMABINDU
Published: September 2021

Objective: To study about prevalence in anemia among the antenatal women, its clinical features, and access the severity and its treatment response.
Methods: A hospital-based retrospective study on the prevalence of anemia among the antenatal women in tertiary care hospital for 6 months duration in gynecology and obstetrics department. In evaluating pregnant women with anemia, it is essential to do a complete history and physical examination, as well as complete blood count with indices and a blood smear examination. Based on these findings, other test such as ferritin and serum or red cell folate may be ordered. Because of normal physiologic changes in pregnancy that effect the hematocrit, indices, and some other parameters, diagnosing true anemia, as well as the etiology of anemia, is challenging.
Results and Discussion: In this retrospective study, the prevalence of Anemia in pregnancy in a tertiary care hospital was evaluated and determined in fifty patients. The most common age group was between 21 and 25 years i.e., (21 patients) 42%. Among 50 patients, majority of them, i.e., 35 patients (70%) were treated with Injection. Iron Sucrose (200 mg). In this study, increase in prevalence were seen majorly in the third trimester, i.e., 25 patients (50%) of which 22 patients (88%) were with moderate anemia with 7.9 gm/dl average hemoglobin (Hb) percentage and 3 patients (12%) were with mild anemia with 9.3 gm/dl average Hb percentage.
Conclusion: The plan of management for anemia complicating pregnancy depends on the type of anemia. Oral iron therapy is the route of choice in women with mild to moderate anemia and for severe anemia in pregnant women <30 weeks of gestation. The rise of Hb with parenteral iron therapy is almost the same (avg: 1gm/dl/week) as that of oral iron therapy.
POST STROKE DEPRESSION AND ANXIETY: PREVALANCE AND CORRELATES
Authors: NOUSHAD NASMI , S SACHITA , VARUGHESE SHILPA ANNA , K JOY SIJIMOL , JOSE SNEHA
Published: September 2021

Objectives: The objective of the study is to evaluate the prevalence of depression and anxiety in post-stroke patients and identify its predictors.
Materials and Methods: This study was conducted for a period of 6 months among 81 patients admitted with stroke in SSIMS and RC, Davangere. The information compiled from patient data collection form was assessed for comorbid conditions and type of stroke. Assessment for depression and anxiety was conducted using Hamilton D (HAM-D) and HAM-A scale and information of location of lesion was obtained from patient’s neuroimaging results. Quality of life (QOL) of post-stroke was assessed using stroke and aphasia QOL (SAQOL) questionnaire. Follow-up was conducted for patients who were diagnosed with depression and anxiety within 1 to 3 months.
Results: Depression was more prevalent as compared to anxiety in post-stroke patients and was predominant in males and between the ages 61 and 70 years. Hypertension and diabetes were found to be a major comorbid conditions in such patients. Factors contributing to increased risk of depression and anxiety after stroke include age, sex, comorbidities, lesion location, and type of stroke. Post-stroke depression (PSD) and anxiety showed statistically significant association with left-sided lesion.
Conclusion: PSD and anxiety are a relatively common complications and can result in poor QOL in stroke patients. Early detection of depression and anxiety symptoms may assist functional recovery and improve QOL in stroke patients. Careful evaluation of PSD and post-stroke anxiety should be integrated into clinical care of stroke patients.
COMPARISON OF INTRATHECAL HYPERBARIC ROPIVACAINE 0.5% WITH AND WITHOUT 75 MG MAGNESIUM SULFATE AS AN ADJUVANT FOR INFRA UMBILICAL SURGERIES: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL
Authors: SRIKANTH SRINIDHI , CHARLES S ANTONY JOHN , KAMAESHAR YASHA , MISHRA GAYATRI
Published: September 2021

Objective: Intrathecal magnesium as an adjuvant to hyperbaric ropivacaine could extend duration of sensory blockade and improve the quality of post-operative analgesia; thereby reducing opioid requirements and its adverse effects. Hence, we conducted this prospective, randomized, double-blind clinical trial to observe its effects for day care surgeries.
Methods: After obtaining institutional ethical committee approval and registration of trial, patients’ informed consent was taken and eighty adult patients of either gender, ASA 1 and 2, posted for infra umbilical surgeries were divided into two groups: Group RM received 3 ml hyperbaric Ropivacaine with 0.75 ml magnesium sulfate (75 mg) and Group R received 3 ml hyperbaric Ropivacaine with 0.75 ml sterile water. Sensory and motor blockade parameters, hemodynamic variables, and adverse effects were monitored, analyzed using appropriate statistical tests.
Results: Total duration of sensory blockade was significantly prolonged in Group RM compared to Group R (242.8 ± 9.9 versus 186.6 ± 8.4 min) (***p<0.001). Complete motor regression was observed significantly earlier in Group RM than in Group R (151.3 ± 7.8 versus 184.7 ± 5.6 min) (*p<0.05). Post-operative pain free interval was significantly prolonged in group RM compared to group R (725.2 ± 18.6 vs. 515.2 ± 17.8 min) (***p<0.001).
Conclusion: We concluded that intrathecal magnesium as an adjuvant to hyperbaric Ropivacaine significantly prolonged both sensory blockade duration, post-operative pain-free interval without increasing motor blockade duration and the incidence of adverse effects.
Research on early grammatical gender processing: what do we know about Spanish-speaking children?
Authors: Ogneva Anastasiia
Published: September 2021

Este artículo reseña estudios recientes sobre adquisición y procesamiento del género gramatical en la población hispanohablante. Se comentan estudios con hablantes monolingües, bilingües, hablantes de herencia y niños diagnosticados con el Trastorno Evolutivo del Lenguaje (TEL). El enfoque principal es la revisión de estudios centrados en el procesamiento del género gramatical durante la comprensión de oraciones por parte de niños hispanohablantes. Según los resultados de dichas investigaciones, la adquisición del género gramatical parece ser diferente entre niños con TEL y aquellos con desarrollo típico. Además, desde edades tempranas, los niños hispanohablantes con desarrollo típico muestran sensibilidad a las “coocurrencias distribucionales de género”, es decir, a la información sobre el género gramatical que proporcionan los determinantes y artículos. Asimismo, se incluyen estudios sobre el procesamiento del género gramatical por parte de adultos, que muestran el efecto facilitador del género transparente durante el reconocimiento de nombres.
Hemorrhoidal artery ligation without using a doppler guide: Is it a feasible and safe technique?
Authors: Degerli Mahmut Said , Yildirim Dogan , Cakir Mikail , Akturk Okan Murat , Alpay Orcun , Canturk Alp Omer , Kandaz Omer Faruk , Akinci Muzaffer
Published: September 2021

The objective of this work was to analyze the results of the hemorrhoidal artery ligation technique without using a doppler guide, in patients with grade 3 hemorrhoidal disease; by evaluating cost-effectiveness, operation time, recurrence rate, postoperative pain, and secondary outcomes. A hemorrhoidal artery ligation procedure, without using a doppler guide, was performed on 43 patients (15 females, 28 males) with grade 3 symptomatic hemorrhoidal disease, from June 2015 to June 2019, in the Haseki Training and Research Hospital, Istanbul, Turkey. Patients were followed up clinically for one month. They completed a questionnaire within one year after their procedure. The median age was 46 years (range: 24 to 82 years). The main complaints were bleeding in 27 patients, pain in 22 patients, and skin tag in 14 patients. The mean preoperative VAS score was 3.4. The mean operating time was 18 mins (range: 13 to 25 min). All patients remained hospitalized for 24 h. Reoperation was necessary for only one patient because of bleeding. One year after the surgery, the pain was resolved in 21 (95.4%) out of 22 patients with preoperative pain, and bleeding resolved in 25 (92.5%) out of 27 patients with preoperative bleeding. The hemorrhoidal artery ligation is a simple method with a shorter learning curve producing similar postoperative results to other surgical procedures. The surgical technique is cost-effective as it does not require any particular device (anoscope with Doppler ultrasound) to apply.
Hepatocyte Nuclear Factor -1α stimulates cervical cancer cells to migrate and invade through regulating pyruvate kinase L/R
Authors: Tao Xiao-Ling , Yu Wei-Chang , Chen De-Jun , Wang Li-Ming , Liu Lu , Xing Qi
Published: September 2021

This study was aimed to analyze the role of hepatocyte nuclear factor -1α (HNF-1α) in regulating migrative and invasive potentials in cervical cancer via the involvement of pyruvate kinase L/R (PKLR). The expression of HNF-1α and PKLR in cervical cancer tissues classified by tumor size and FIGO (Federation International of Gynecology and Obstetrics) stage were detected by qRT-PCR. The expression correlation between HNF-1α and PKLR in cervical cancer tissues was analyzed by Pearson correlation test. After intervening HNF-1α and PKLR levels in SiHa and Hela cells, their migratory and invasive abilities were examined by the Transwell assay. HNF-1α was upregulated in cervical cancer tissues, particularly those with large tumor size or advanced FIGO stage. PKLR was highly expressed in cervical cancer tissues as well, presenting a positive correlation with the HNF-1α level. Knockdown of HNF-1α attenuated migratory and invasive abilities in SiHa cells, whereas overexpression of HNF-1α enhanced migratory and invasive abilities in SiHa cells. PKLR was able to abolish the regulatory effects of HNF-1α on cervical cancer metastasis. HNF-1α and PKLR synergistically promote cervical cancer to migrate and invade.
Chlamydia trachomatis. Co-factor or factor in cancer of the cervix?
Authors: Núñez Troconis José
Published: September 2021

The objective of this article was to review and to analyze the possible role that Chlamydia trachomatis has as a co-factor in the origin and development of cervical cancer. For that purpose, the Latin-American and international bibliography was reviewed using the Pub-Med, Google Scholar, Springer, the Cochrane Library, Embase, Scielo, Imbiomed-L, Redalyc and Latindex databases. The searches included the key words: Chlamydia trachomatis, epidemiology of Chlamydia trachomatis, epidemiology of cervical cancer, Chlamydia trachomatis and infection, Chlamydia trachomatis and inflammation mechanisms, cervical cancer and co-factors, sexually transmitted infections and cervical cancer, cancer and inflammation mechanisms, carcinogenesis, inflammation mechanisms. Publications from 1970 to June 2020 were reviewed and analyzed. This review article analyzes the possible mechanisms that Chlamydia trachomatis could play in the carcinogenesis of the cervical cancer as a co-factor with the human papilloma virus or as an independent factor.
Analytical Hierarchy Process of human resources performance: perceptions perspective
Authors: Hermawati Adya
Published: September 2021

This research aims to recommend a policy model as the base in making strategies to improve the performance and sustainable competitiveness of Micro, Small & Medium Enterprises (MSMEs) in the tourism sector. Variables used by this research are role, actor, and priority. These variables are measured by weighing them against human resource performance. Method of research involves quantitative and qualitative approaches. The sampling technique is purposive sampling. The research results comprise three findings, which all refer to the results of assessment done by the employees of MSMEs regarding the relationship between variables and MSMEs performance. First, transglobal leadership is the most needed criterion to improve performance. The second is that Community is the actor whose role is most needed to improve performance. Finally, the third is productivity and professionality as a priority.
The Development of Supervisory Functions as Experienced by Attending Physicians and Medical Trainees: A Qualitative Directed Content Analysis
Authors: Ahmady Soleiman , Seidi Masoumeh
Published: September 2021

Objectives: this study aimed to identify the core components of supervisory functions experienced by attending physicians and medical trainees.
Methods: This qualitative study was conducted based on the directed content analysis. Intentional sampling with maximum variation was used to select the required participants among medical trainees and attending physicians in teaching hospitals at Shahid Beheshti and Hamadan University of Medical Sciences, Iran. A semi-structured interview was used as the most important method of data collection in this study. Data saturation was reached after interviewing 20 participants.
Results: In this study, 11 categories were identified through performing the interviews. Management supervision includes Academic Discipline and Monitor and follows the implementation of the curriculum. The themes of educational supervision were as follows: Empowering of non-faculty educators, Control over trainees' academic achievement, Supervision of trainees' performance, and Activitiesâ€™ educators of evaluation Supportive supervision included improving traineesâ€™ resilience, Provide functional support and Diversity and condition of providing support services. As well, the fourth theme from the participantsâ€™ initial codes was observed to be professionalism, including Professional accountability and Respect for patient rights.
Conclusions: This study highlighted the important aspects for which clinical supervision functions need to be improved, to maximize their benefit to medical students. Supervisors are responsible to ensure these three functions occur across the course. Care must be taken to ensure that one function does not become the focus.
Ajwa seeds (Phoenix dactylifera L.) suspension exerted antidiabetic and antihyperlipidemic effects against streptozotocin-induced diabetes in rats by downregulating insulin expression in the pancreatic beta islets
Authors: Alahmadi Ahlam Abdulaziz , Banayah Hessah Mohammed
Published: September 2021

Objectives: This study investigated the antidiabetic and antihyperlipidemic effects of the powdered seeds of Ajwa Al-Madina in streptozotocin (STZ)-induced diabetes in rats. Besides investigating the possible underlying mechanisms.
Methods: Rats were assigned to one of six groups (n = 5) as follows: normal control, vehicle control, Ajwa seeds control, diabetic control, Diabetic + Metformin, and Diabetic + Ajwa seeds. Metformin and Ajwa seeds were injected into rats orally via oral gavage 6 days/week along 4 weeks period
Results: Ajwa seeds decreased fasting serum glucose, increased fasting serum insulin and decreased fasting serum triglycerides cholesterol, low-density lipoprotein, and increased fasting serum high-density lipoprotein. Besides, it upregulated insulin protein immunoexpression in the beta cells of Langerhans islets. Ajwa seed also preserved the normal histological structure of the pancreatic beta cells tissue.
Conclusion: Ajwa seeds produced significant hypoglycemic and hypolipidemic effects in diabetic rats mainly through enhancement of insulin secretion. The plant is a promising adjunctive therapy in diabetes mellitus treatment.
“Imam, don’t go to Groznaya”: on the fundamental idea of the historical novel “The Wild Terek“ by Hadji-Murat Muguev
Authors: Khugaev Irlan S.
Published: September 2021

Hadji-Murat Muguev (1893-1968) was a prominent representative of Soviet literature, an Ossetian by origin who wrote in Russian. As a veteran of three wars (WWI, the Civil War, and WWII), Hadji-Murat Muguev devoted most of his works to military topics. The Wild Terek (1937-1968), a historical novel about the Caucasian War of the 19th century, is considered his magnum opus. The topic proposed herein is of interest due to, first, the desirability of a new reading of the text of Soviet literature, especially as regards its historical concept; secondly, a vivid ethno-cultural character of the material; thirdly, a peculiar poetic manner of translingual (written in Russian) literature of peoples of the Russian Caucasus. It is noteworthy that the novel has not received due consideration by contemporary literary criticism; as for the Soviet period, the then critics were carried away with the major ideological issues provoked by its contents and thus disregarded its imaginary characters, internal framework and particular motifs that worked for the fundamental idea. In this article, by relying on a number of key factors, we intend to highlight some ideologic discourses of Muguevs text referring to the authors humanistic system and signs of forthcoming peace between the peoples of the Caucasus and Russia.
Diversity of Genre in Post-Colonial Literature
Authors: Shcherbak Nina F.
Published: September 2021

The main aim of this article is to outline main tendencies in the development of post-colonial literature in the face of Jean Rhys and her novel Wide Sargasso Sea as a vivid example of starting attempt to break a white-domineering view of Asian countries and build up a new identity. Research attempts to refer to a wider scope of literary texts, including the ones that outline issues and problems related to the so-called invasion narratives. The term invasion narratives is seen as referring to a number of different texts, including English Patient by Michael Ondaatje or the Reader by Bernhard Schlink. One of numerous possibilities of analyzing post-colonial literature is the analysis of the novels by Zadie Smith White Teeth and on Beauty, the latter being a good example of a return to realism and actualizing what is called coined as the meanwhile. Special attention is given to meta-modernism and its function on the contemporary cultural and literary scene, above all with its attempt to start a neo-romantic direct kind of prose, or verse, simple in its form, yet aiming to construct new identities. This kind of prose incorporates the narratives exploring different traumas, including trans-generational traumas.
Interregional Scientific Seminar “Preservation and Development of Siberian Indigenous Languages and Cultures”
Authors: Borgoiakova Tamara G. , Guseinova Aurika V.
Published: September 2021

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Territorial Management in 2021: New Approaches to Traditional Solutions
Authors: Shamakhov V. A. , Mezhevich N. M.
Published: September 2021

Key approaches to territorial management known in the world have been tried (tested) in Russia since the time of the Moscow Principality. It is almost impossible to propose new ones, but previous practices are becoming new in signifcance. In the specifc economic and political conditions of 2021, several initiatives were announced and serious decisions were made regarding territorial administration in the Russian Federation. This proposal is devoted to this article.
Post-Dodon Moldova: Prospects for the Development of RussianMoldovan Relations
Authors: Malchushkin N. A.
Published: September 2021

The article is dedicated to the prospects for the development of Russian-Moldovan relations after the victory of Maia Sandu in the presidential elections in the Republic of Moldova. The work examines the historical background and the current state of political and economic cooperation between Russia and Moldova. It is outlined that Russia retains its importance for Moldova in the felds of energy security and food exports; at the same time, a signifcant economic imbalance in relations is emphasized. The authors point to the instability of bilateral interaction due to three circumstances: external factors (primarily, the inﬂuence of the European Union), the stance of the newly elected president of the republic, and the balance of political forces in the national parliament of Moldova. According to the authors, the assumption of power by a pro-European politician does not imply Moldova’s unilateral refusal to cooperate with Russia. Despite the obvious intention to accelerate the country’s integration into the European Union, the new leadership is not yet ready to abandon the dialogue with Moscow. In the political, economic, and military profles of Moldova, Russia remains one of the most important partners. Since the internal political transformations in the republic carry the potential to diminish Russian inﬂuence over Moldova, the authors highlight possible steps on the Russian side that are capable of strengthening the existing foundation of positive interaction between countries, based on a study of the current confguration of bilateral relations. It is particularly underlined that against the background of the existing parameters of the modern system of international relations, even in the event of the most pessimistic scenario, the damage to Russian interests (apart from reputational losses) can be assessed as relatively insignifcant.
State-Business Partnership in Modern Conditions: Prospects for Transformation
Authors: Plotnikov V. A.
Published: September 2021

The complexity of the economy and the increase in uncertainty, as well as the need to solve ambitious tasks aimed at achieving strategic national development goals, force us to search for new forms and mechanisms for starting long-term economic growth. One such mechanism is public-private partnership, understood in the article in a broad sense, as an extensive set of forms of mutually benefcial interaction between the state and business. The article analyses the prerequisites of intensifying partnership in the modern Russian economy and assesses the directions of its transformation.
Philosophical Consulting as a Tool for “Problem Hacking” in Human Management in Organizations
Authors: Ivanova O. E.
Published: September 2021

Consulting focused on comprehending organizational problems and breaking the patterns of their managerial solution is in demand in a chaotic, dynamic world. This counseling tool is able to counter the uncertainty of the external environment with a clear understanding of the or ganizational event. The aim of the paper is to investigate philosophical consulting as an intellectual tool for “problem hacking” in Human Management in organization.

Theoretical basis of the research: the analytical approach to human resource management, the ideas of the international movement of philosophical practice, the edifying philosophy of R. Rorty, ideas of “problem hacking”. Research methods used in the work: philosophical (conceptual) analysis, decomposition, conceptualization.

Results. Philosophical consulting is justifed as an analytical and value-based tool of facilitation of “problem hacking” in Human Management in the organization, the features of philosophical consulting as a management consulting are revealed. With the purpose of hacking problems at the level of foundations — meanings and values — according to each stage of “problem hacking”, the function of facilitation of philosophical consulting is revealed. HRMproblems are classifed into process groups: “cooperation”, “change and development”, “measurement and evaluation”. Typical HR-challenge are identifed — the feld of potential conﬂicts.

The concept of HR-call is formulated and elements of the problem solution construction are developed: philosophical idea of the answer to HR-challenge and relevant managerial methods of realization.

Application of value-analytical and design tools of philosophical consulting to “hacking” organizational problems — the company’s response to the challenges of the VUCA world, “defcit of meaning” in Russian companies, the employers’ demand for problem-solving skills in the next fve years. The limitations of the research are identifed.
Impuesto sobre las emisiones de dióxido de carbono: un análisis para el caso europeo
Authors: Camargo Mayorga David Andrés , Ruiz Acosta Liliana Elizabeth , Cardona García Octavio
Published: September 2021

El presente artículo realiza un análisis de datos panel con vectores autorregresivos (PVAR) para determinar la efectividad de los impuestos ambientales sobre la emisión de dióxido de carbono (CO2) en los sectores de minería y transporte en treinta y un países europeos. Se hace el análisis econométrico con variables simultáneas, como lo son los impuestos y la generación de CO2, las cuales se afectan una con la otra. El resultado más destacado de este estudio muestra que las emisiones de CO2 de los sectores de transporte y minería no se ven afectadas por los impuestos. Esta discusión es importante para Colombia, que recién cobra impuestos al carbono y tiene potencial en el uso de energías fósiles que generan emisiones contaminantes.
Preferencias sobre las urbanizaciones cerradas como modelo urbanístico en la ciudad de Varsovia
Authors: Fuhrmann Magdalena
Published: September 2021

Las urbanizaciones cerradas fueron una de las formas de desarrollo de la vivienda en Polonia durante la última década del siglo XX e inicios del XXI. Las ciudades experimentaron una especie de florecimiento en este tipo de vivienda. Sin embargo, en la actualidad estas urbanizaciones cerradas han dejado de ser relevantes entre los planificadores urbanísticos, las autoridades de las ciudades, así como entre los residentes. El objetivo de este artículo es presentar los resultados derivados de una encuesta con una muestra de ciento una personas sobre las preferencias de vivienda en Varsovia. Se concluye que la falta de interés sobre los pisos en urbanizaciones cerradas responde a un asunto de percepción en el prestigio y avance socioeconómico de las personas.
Asistencia a eventos de artes escénicas en Colombia: análisis microeconómico aplicando modelos de selección muestral
Authors: Espinal Monsalve Nora Elena , Ramos Ramirez Andrey David , Balbín Espinal Isabel
Published: September 2021

En este artículo se analizan los determinantes de la asistencia y frecuencia de asistencia a artes escénicas en Colombia. Con datos de la Encuesta de Consumo Cultural del 2014, se estiman los modelos de selección de Heckman para variable dependiente ordenada que permiten remover el sesgo de selección muestral que aparece cuando se modelan estas dos variables de manera independiente. Los resultados indican que la acumulación de capital cultural y las restricciones de tiempo son los principales determinantes del consumo de esta actividad en Colombia.
Poder Judiciário e Combate à Corrupção: Atuação e Discursos do Tribunal Regional Federal da 4ª Região
Authors: Kobielski Marina Balestrin , Azevedo Rodrigo Ghiringhelli
Published: September 2021

O artigo propõe a análise de uma mudança nos processos de criminalização, com a inclusão de poderosos na pauta de combate ao crime, deixando em menor evidencia os crimes comuns, da chamada criminalidade de rua, para um aprofundamento da persecução de crimes cometidos por grandes empresários e políticos. Destaca-se, inicialmente, que a clientela clássica do sistema penal, ou seja, negros, pobres, de baixa escolaridade, sem dúvida não deixará de ser criminalizada e continuará ocupando, majoritariamente, os cárceres brasileiros. Entretanto, tendo em vista que os chamados crimes de colarinho branco sempre ocorreram e raramente foram, de fato, criminalizados, essa mudança de perspectiva é um objeto de estudo socialmente relevante. O que se pretende responder, portanto, é se, tendo em vista essas grandes operações policiais mais recentes, que indicam uma mudança nos processos de criminalização que envolvem a corrupção, houve uma mudança no padrão de decisões do TRF4 em relação aos crimes de corrupção ativa e corrupção passiva. Após revisão bibliográfica, foi realizada pesquisa documental em acórdãos2 de recursos de apelação do Tribunal Regional Federal da 4ª Região envolvendo os crimes de corrupção ativa e passiva em 2018. Os dados obtidos são analisados tanto a partir de abordagem estatística descritiva quanto da qualitativa, para demonstrar um recrudescimento nas decisões que envolvem tais delitos.
Categorização e Qualificação dos Queijos da Auvergne (França): Relações entre Expertise Científica e os Selos de Denominação de Origem
Authors: Bertussi Mayra Lafoz
Published: September 2021

O artigo reflete sobre as appellations d’origine contrôlée, uma das denominações de origem de maior reconhecimento na França. A inserção desse modelo para além do território francês, com o reconhecimento das appellations d’origine protégée junto à União Europeia e à Organização Mundial do Comércio, desencadeou uma série de controvérsias quanto à qualidade alimentar. Na Europa, concomitante à regulamentação dessa certificação para o conjunto de países membros, houve um incentivo para a solidificação da justificativa legal do estatuto privilegiado que as denominações de origem gozavam face às transações comerciais. Nesse contexto, foi estimulado um processo de legitimação dos selos via intensificação de critérios produtivos. Queijos fabricados a partir do leite cru foram qualificados como aqueles capazes de preservar a diversidade sensorial, gustativa e cognitiva do terroir. A partir do método etnográfico e de uma perspectiva dialógica, o presente artigo busca refletir sobre o trabalho de instituições científicas que, inseridas nesse contexto de legitimação das appellations d’origine contrôlée, trabalharam pela viabilidade sanitária dos queijos de leite cru. O objetivo, nesse caso, reside numa análise sobre a influência dos conhecimentos científicos na categorização e qualificação da produção alimentar. Como conclusão, o artigo observa que, diferentemente dos casos em que o conhecimento científico é acionado para assegurar a inocuidade das inovações tecnológicas no mercado alimentar, a expertise científica se volta para a legitimação do que é considerado uma produção tradicional.
Direito à Cidade e Direito ao Trabalho: Uma Análise das Formas de Circulação dos Mototaxistas de Niterói, Rio de Janeiro
Authors: Rocha (INCT-InEAC) Talitha Mirian do Amaral
Published: September 2021

Este artigo discute o direito à cidade a partir da análise das formas de circulação dos mototaxistas da comunidade do Morro do Estado, localizada no Centro de Niterói, Rio de Janeiro. Os dados empíricos foram coletados durante o trabalho de campo realizado por mais de um ano, acompanhando o ofício desses mototaxistas. Em 2015, foi aprovada uma lei regularizando o moto táxi em Niterói, mas não era regulamentado formalmente pela gestão pública municipal até o final da pesquisa. A falta dessa regulamentação foi utilizada algumas vezes enquanto argumento pelos agentes de segurança pública para não permitir que esses sujeitos exerçam o seu ofício na principal Praça do Centro da Cidade. Por outro lado, para os mototaxistas, exigir que a lei fosse implementada pela gestão municipal era uma maneira de ter sua identidade de trabalhador reconhecida pela sociedade. Nesse sentido, percebe-se que a intenção desses sujeitos era, sobretudo, ter direito ao trabalho, mas, para conseguirem ter esses direitos contemplados, eles precisavam também ter o direito de estar e ocupar a cidade. A partir do caso empírico em questão, almeja-se refletir que para a incorporação do conceito de direito à cidade no Brasil, além de se levar em conta as desigualdades materiais, é preciso considerar a desigualdade de acesso a direitos de acordo com a nossa sensibilidade jurídica.
Avaliação, Classificação e Decisões sobre Embriões In Vitro: As (Re)Apropriações das Normas pelos Embriologistas
Authors: Delaunay (NOVA) Catarina , Gouveia (NOVA) Luís
Published: September 2021

Este artigo descreve, analisa e discute as formas de relação dos embriologistas com as normas padronizadas que orientam a sua prática profissional no âmbito das técnicas de Procriação Medicamente Assistida em termos de avaliação, classificação e tomada de decisão sobre o embrião humano criado in vitro. Com base em entrevistas realizadas com embriologistas de centros públicos e privados de Procriação Medicamente Assistida, problematizamos as formas de adesão e conformação à governança pela norma, ou, como contraposto, às modalidades de composição, adaptação, negociação, ressignificação e crítica das normatividades estandardizadas por parte desses profissionais de saúde de acordo com os seus próprios esquemas cognitivos, saberes experienciais e padrões normativos. Sistematizamos os critérios usados na decisão sobre os embriões a transferir, congelar ou descartar e propomos uma gramática de lógicas em termos de atitudes  e posicionamentos, mais ou menos rígidos, dos embriologistas diante dos standards e guidelines de avaliação e da classificação dos embriões.