bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting psychological distress in advanced ovarian cancer patients during the COVID-19 pandemic
Authors: Rennoldson Mike , Baliousis Michael , Potter Adam , Ashraf Ehab , Gajjar Ketan
Published: July 2024

Purpose

This longitudinal study investigated distress rates in patients with advanced ovarian cancer during the COVID-19 pandemic and examined whether time, illness representations, and coping strategies predicted distress levels.

Methods

UK patients with stage 3 or 4 ovarian cancer were recruited between September 2020 and March 2021. Data were collected at baseline (T0), 2 months (T1), and 4 months (T2) post-enrolment. Validated questionnaires assessed distress (anxiety, depression, PTSD, fear of progression) and predictors (coping strategies and illness perceptions), analysed via multilevel modelling.

Results

Seventy-two participants returned a questionnaire at T0, decreasing to 49 by T2. High distress was observed, with over 50% of participants experiencing anxiety and depression consistently. Nearly 60% reported clinical levels of fear of progression at some point. PTSD rates resembled the general population. Although distress levels remained stable over time, some individual variability was observed. Time had minimal effect on distress. Coping strategies and illness perceptions remained stable. Threatening illness perceptions consistently predicted distress, while specific coping strategies such as active coping, acceptance, self-blame, and humour predicted various aspects of distress. Together, these factors explained up to half of the distress variance.

Conclusion

The findings have implications for routine screening for distress and the inclusion of psychological treatment pathways in advanced ovarian cancer care. Addressing illness representations is crucial, with attention to informational support. Future research should explore the long-term effects of heightened distress and the effectiveness of interventions targeting illness perceptions. This study informs current clinical practice and future pandemic preparedness in cancer care.
An Effective Barrier Coating Technology Against Premature Bolt Failures in Underground Mines
Authors: Chen Honghao , Kimyon Önder , Gunawan Cindy , Lamei Ramandi Hamed , Craig Peter , Chen Renxun , Kabir Imrana , Kumar Naresh , Manefield Michael , Crosky Alan , Canbulat Ismet , Saydam Serkan
Published: July 2024

Significant safety and economic consequences accompany the premature failure of bolts, posing sustainability challenges for mining operations. Previous studies have indicated that hydrogen-induced stress corrosion cracking (HISCC), primarily influenced by microbial activities termed microbiologically influenced stress corrosion cracking (MISCC), stands as a major contributor to the premature failure of bolts in underground mines. Presently, an effective mechanism to mitigate these premature failures is lacking. In this study, multiple commercially available coatings undergo testing to assess their susceptibility and suitability in preventing HISCC and MISCC. Additionally, a purpose-developed coating is examined. The results reveal that the tested commercially available coatings either fail to prevent these types of corrosion or are unsuitable for the intricate conditions within underground mines. The laboratory results show the coating has a significant anti-acidic corrosion and anti-MISCC performance. Conversely, the coating formulated in this study successfully averts both MISCC and HISCC, proving its applicability within the complex geological environments prevalent in mines. This breakthrough offers a promising solution to mitigate premature bolt failures in complex underground geological environments. The developed coating presents a viable way forward for enhancing safety, reducing economic losses, and improving the overall sustainability of mining operations.
Advantages of stereolithographic 3D printing in the fabrication of the Affiblot device for dot-blot assays
Authors: Novotny Jakub , Svobodova Zuzana , Ilicova Marie , Hruskova Dominika , Kostalova Jana , Bilkova Zuzana , Foret Frantisek
Published: July 2024

In stereolithographic (SLA) 3D printing, objects are constructed by exposing layers of photocurable resin to UV light. It is a highly user-friendly fabrication method that opens a possibility for technology sharing through CAD file online libraries. Here, we present a prototyping procedure of a microfluidics-enhanced dot-blot device (Affiblot) designed for simple and inexpensive screening of affinity molecule characteristics (antibodies, oligonucleotides, cell receptors, etc.). The incorporation of microfluidic features makes sample processing user-friendly, less time-consuming, and less laborious, all performed completely on-device, distinguishing it from other dot-blot devices. Initially, the Affiblot device was fabricated using CNC machining, which required significant investment in manual post-processing and resulted in low reproducibility. Utilization of SLA 3D printing reduced the amount of manual post-processing, which significantly streamlined the prototyping process. Moreover, it enabled the fabrication of previously impossible features, including internal fluidic channels. While 3D printing of sub-millimeter microchannels usually requires custom-built printers, we were able to fabricate microfluidic features on a readily available commercial printer. Open microchannels in the size range 200–300 μm could be fabricated with reliable repeatability and sealed with a replaceable foil. Economic aspects of device fabrication are also discussed.

Graphical abstract
Modeling end-to-end delays in TSCH wireless sensor networks using queuing theory and combinatorics
Authors: Shudrenko Yevhenii , Timm-Giel Andreas
Published: July 2024

Wireless communication offers significant advantages in terms of flexibility, coverage and maintenance compared to wired solutions and is being actively deployed in the industry. IEEE 802.15.4 standardizes the Physical and the Medium Access Control (MAC) layer for Low Power and Lossy Networks (LLNs) and features Timeslotted Channel Hopping (TSCH) for reliable, low-latency communication with scheduling capabilities. Multiple scheduling schemes were proposed to address Quality of Service (QoS) in challenging scenarios. However, most of them are evaluated through simulations and experiments, which are often time-consuming and may be difficult to reproduce. Analytical modeling of TSCH performance is lacking, as only one-hop communication with simplified traffic patterns is considered in state-of-the-art. This work proposes a new framework based on queuing theory and combinatorics to evaluate end-to-end delays in multihop TSCH networks of arbitrary topology, traffic and link conditions. The framework is validated in simulations using OMNeT++ and shows below 6% root-mean-square error (RMSE), providing quick and reliable latency estimation tool to support decision-making and enable formalized comparison of existing scheduling solutions.
Computer-aided diagnosis of Alzheimer’s disease and neurocognitive disorders with multimodal Bi-Vision Transformer (BiViT)
Authors: Shah S. Muhammad Ahmed Hassan , Khan Muhammad Qasim , Rizwan Atif , Jan Sana Ullah , Samee Nagwan Abdel , Jamjoom Mona M.
Published: July 2024

Cognitive disorders affect various cognitive functions that can have a substantial impact on individual’s daily life. Alzheimer’s disease (AD) is one of such well-known cognitive disorders. Early detection and treatment of cognitive diseases using artificial intelligence can help contain them. However, the complex spatial relationships and long-range dependencies found in medical imaging data present challenges in achieving the objective. Moreover, for a few years, the application of transformers in imaging has emerged as a promising area of research. A reason can be transformer’s impressive capabilities of tackling spatial relationships and long-range dependency challenges in two ways, i.e., (1) using their self-attention mechanism to generate comprehensive features, and (2) capture complex patterns by incorporating global context and long-range dependencies. In this work, a Bi-Vision Transformer (BiViT) architecture is proposed for classifying different stages of AD, and multiple types of cognitive disorders from 2-dimensional MRI imaging data. More specifically, the transformer is composed of two novel modules, namely Mutual Latent Fusion (MLF) and Parallel Coupled Encoding Strategy (PCES), for effective feature learning. Two different datasets have been used to evaluate the performance of proposed BiViT-based architecture. The first dataset contain several classes such as mild or moderate demented stages of the AD. The other dataset is composed of samples from patients with AD and different cognitive disorders such as mild, early, or moderate impairments. For comprehensive comparison, a multiple transfer learning algorithm and a deep autoencoder have been each trained on both datasets. The results show that the proposed BiViT-based model achieves an accuracy of 96.38% on the AD dataset. However, when applied to cognitive disease data, the accuracy slightly decreases below 96% which can be resulted due to smaller amount of data and imbalance in data distribution. Nevertheless, given the results, it can be hypothesized that the proposed algorithm can perform better if the imbalanced distribution and limited availability problems in data can be addressed.

Graphical abstract
Plant-based proteins: clinical and technological importance
Authors: Medina-Vera Isabel , Avila-Nava Azalia , León-López Liliana , Gutiérrez-Solis Ana Ligia , Talamantes-Gómez José Moisés , Márquez-Mota Claudia C.
Published: July 2024

Healthy and sustainable diets have seen a surge in popularity in recent years, driven by a desire to consume foods that not only help health but also have a favorable influence on the environment, such as plant-based proteins. This has created controversy because plant-based proteins may not always contain all the amino acids required by the organism. However, protein extraction methods have been developed due to technological advancements to boost their nutritional worth. Furthermore, certain chemicals, such as bioactive peptides, have been identified and linked to favorable health effects. As a result, the current analysis focuses on the primary plant-based protein sources, their chemical composition, and the molecular mechanism activated by the amino acid types of present. It also discusses plant protein extraction techniques, bioactive substances derived from these sources, product development using plant protein, and the therapeutic benefits of these plant-based proteins in clinical research.
Global prevalence of claudin 18 isoform 2 in tumors of patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma
Authors: Shitara Kohei , Xu Rui-Hua , Ajani Jaffer A. , Moran Diarmuid , Guerrero Abraham , Li Ran , Pavese Janet , Matsangou Maria , Bhattacharya Pranob , Ueno Yoko , Wang Xuewei , Shah Manish A.
Published: July 2024

Background

Limited data exist for global prevalence of claudin 18 isoform 2 (CLDN18.2) positivity and association of CLDN18.2 status with clinical and tumor characteristics in patients with locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma. We report prevalence of CLDN18.2 positivity (phase 3; SPOTLIGHT, NCT03504397; GLOW, NCT03653507) and concordance of CLDN18.2 status between a subset of pair-matched tumor samples (phase 2, ILUSTRO, NCT03505320; phase 1, NCT03528629) from clinical studies of zolbetuximab.

Methods

Tumor samples from patients with LA unresectable or mG/GEJ adenocarcinoma were tested for CLDN18.2 status by immunohistochemistry. Human epidermal growth factor receptor 2 (HER2) expression was tested per central or local assessment.

Results

Across SPOTLIGHT and GLOW, the prevalence of CLDN18.2 positivity (≥ 75% of tumor cells demonstrating moderate-to-strong membranous CLDN18 staining) was 38.4%. Prevalence was similar in gastric versus GEJ adenocarcinoma samples and regardless of collection method (biopsy versus resection) or collection site (primary versus metastatic). CLDN18.2 positivity was most prevalent in patients with diffuse-type tumors. In ILUSTRO and the phase 1 study, concordance of CLDN18.2 positivity was 61.1% between archival (i.e., any time before treatment) and baseline (i.e., ≤ 3 months before first treatment) samples, and concordance of any CLDN18 staining (≥ 1% of tumor cells demonstrating moderate-to-strong membranous CLDN18 staining) was 88.9%.

Conclusions

CLDN18.2 was a highly prevalent biomarker in patients with HER2-negative, LA unresectable or mG/GEJ adenocarcinoma. CLDN18.2 positivity remained relatively stable over time in many patients. Biomarker testing for CLDN18.2 should be considered in standard clinical practice in these patients.
Adrenal Volume Quantitative Visualization Tool by Multiple Parameters and an nnU-Net Deep Learning Automatic Segmentation Model
Authors: Li Yi , Zhao Yingnan , Yang Ping , Li Caihong , Liu Liu , Zhao Xiaofang , Tang Huali , Mao Yun
Published: July 2024

Abnormalities in adrenal gland size may be associated with various diseases. Monitoring the volume of adrenal gland can provide a quantitative imaging indicator for such conditions as adrenal hyperplasia, adrenal adenoma, and adrenal cortical adenocarcinoma. However, current adrenal gland segmentation models have notable limitations in sample selection and imaging parameters, particularly the need for more training on low-dose imaging parameters, which limits the generalization ability of the models, restricting their widespread application in routine clinical practice. We developed a fully automated adrenal gland volume quantification and visualization tool based on the no new U-Net (nnU-Net) for the automatic segmentation of deep learning models to address these issues. We established this tool by using a large dataset with multiple parameters, machine types, radiation doses, slice thicknesses, scanning modes, phases, and adrenal gland morphologies to achieve high accuracy and broad adaptability. The tool can meet clinical needs such as screening, monitoring, and preoperative visualization assistance for adrenal gland diseases. Experimental results demonstrate that our model achieves an overall dice coefficient of 0.88 on all images and 0.87 on low-dose CT scans. Compared to other deep learning models and nnU-Net model tools, our model exhibits higher accuracy and broader adaptability in adrenal gland segmentation.
Airbag Vests in Equestrian Sports: Is Use Associated with Harm?
Authors: Meyer Catherine , Gabriel Fernanda , Schrum Kevin , Hollis Michele , Short Margo , Gould Sara
Published: July 2024

Airbag vests (AV) are increasingly popular in equestrian sports. The efficacy of AV in protecting against serious injury has not been adequately analyzed, nor have product testing standards been established. This study provides an overview of current research to understand AV efficacy and future areas of improvement. A systematic review applying the PRISMA framework, NIH Study Quality Assessment, and CEBM Level of Evidence was conducted. Employing variations of “equestrian sport,” “powered two-wheeled vehicle,” “thoracic injury,” “chest deflection,” “airbag vest,” and “safety vest,” 18 articles were identified for data collection from three recognized research databases and citation searching. In laboratory settings, the ability of AV to protect against thoracic injuries was variable based on concurrent foam-based safety vest (SV) usage, impact speed, and impact mechanism. Studies that examined equestrian falls with AV found an association with increased injury rates and risk. SVs were shown to provide inconclusive efficacy in protecting against injuries in experimental and cohort studies. Protective capabilities depend on material, temperature, and impact mechanism. Further limiting use, equestrians reported not wearing, or incorrectly wearing SV due to unknown benefits, low comfort, and ill fit. In equestrian sports, based on published literature to date, AV have not been associated with a reduction in injury. AV appear to be associated with an increase in the risk of serious or fatal injuries in certain settings. However, research in this area is limited and future, large-scale studies should be conducted to further evaluate the efficacy of the air vests.
Instrumented Mouthguard Decoupling Affects Measured Head Kinematic Accuracy
Authors: Gellner Ryan A. , Begonia Mark T. , Wood Matthew , Rockwell Lewis , Geiman Taylor , Jung Caitlyn , Rowson Steve
Published: July 2024

Many recent studies have used boil-and-bite style instrumented mouthguards to measure head kinematics during impact in sports. Instrumented mouthguards promise greater accuracy than their predecessors because of their superior ability to couple directly to the skull. These mouthguards have been validated in the lab and on the field, but little is known about the effects of decoupling during impact. Decoupling can occur for various reasons, such as poor initial fit, wear-and-tear, or excessive impact forces. To understand how decoupling influences measured kinematic error, we fit a boil-and-bite instrumented mouthguard to a 3D-printed dentition mounted to a National Operating Committee on Standards for Athletic Equipment (NOCSAE) headform. We also instrumented the headform with linear accelerometers and angular rate sensors at its center of gravity (CG). We performed a series of pendulum impact tests, varying impactor face and impact direction. We measured linear acceleration and angular velocity, and we calculated angular acceleration from the mouthguard and the headform CG. We created decoupling conditions by varying the gap between the lower jaw and the bottom face of the mouthguard. We tested three gap conditions: 0 mm (control), 1.6 mm, and 4.8 mm. Mouthguard measurements were transformed to the CG and compared to the reference measurements. We found that gap condition, impact duration, and impact direction significantly influenced mouthguard measurement error. Error was higher for larger gaps and in frontal (front and front boss) conditions. Higher errors were also found in padded conditions, but the mouthguards did not collect all rigid impacts due to inherent limitations. We present characteristic decoupling time history curves for each kinematic measurement. Exemplary frequency spectra indicating characteristic decoupling frequencies are also described. Researchers using boil-and-bite instrumented mouthguards should be aware of their limitations when interpreting results and should seek to address decoupling through advanced post-processing techniques when possible.
Engagement in Care, Awareness, and Interest in Long-Acting Injectable Anti-Retroviral Therapy
Authors: Stout Jacob A. , Allamong Maxwell , Hung Frances , Link Katherine , Chan Cliburn , Muiruri Charles , Sauceda John , McKellar Mehri S.
Published: July 2024

Long Acting Injectable (LAI) therapy to treat HIV is an alternative to daily oral medications. The success of early roll-out of LAI to eligible patients requires a better understanding of patients’ awareness and interest in this novel therapy. We administered an electronic survey to patients attending an urban HIV clinic in the US South. Eligible participants were 18 + years old with a most recent HIV-1 viral load < 200 copies/ml, without any evidence of genotypic resistance to LAI components or chronic hepatitis B. Survey recipients were asked about current treatment, engagement in care, and knowledge of LAI. Between January-April 2023, 480 patients were screened; 319 were eligible, and 155 (49%) completed the survey. The majority (119, 77%) were aware of, and 87 (56%) were interested in LAI. In regression analysis, only age was associated with interest in LAI (OR 0.95, 95% CI 0.92,0.99). Among proposed benefits of injectables, ease of travel without pills, lack of daily pill-taking, and fewer medication interactions were most appealing. Among proposed concerns with injectables, higher cost and insurance coverage of the new medicine were most worrisome. A large majority of people with HIV (PWH) are aware of the newest treatment available, and just over half of our sample expressed interest in LAI. Older age was associated with lower interest in LAI. LAI is appealing for its convenience, privacy, and avoidance of drug interactions, while the increased costs associated with LAI need to be addressed.
Gene-centered metagenome analysis of Vulcano Island soil (Aeolian archipelago, Italy) reveals diverse microbial key players in methane, hydrogen and sulfur cycles
Authors: Angius Federica , Cremers Geert , Frank Jeroen , Witkowski Caitlyn , Pol Arjan , van Alen Theo A. , Jetten Mike S. M. , Op den Camp Huub J. M. , Berben Tom
Published: July 2024

The Aeolian archipelago is known worldwide for its volcanic activity and hydrothermal emissions, of mainly carbon dioxide and hydrogen sulfide. Hydrogen, methane, and carbon monoxide are minor components of these emissions which together can feed large quantities of bacteria and archaea that do contribute to the removal of these notorious greenhouse gases. Here we analyzed the metagenome of samples taken from the Levante bay on Vulcano Island, Italy. Using a gene-centric approach, the hydrothermal vent community appeared to be dominated by Proteobacteria, and Sulfurimonas was the most abundant genus. Metabolic reconstructions highlight a prominent role of formaldehyde oxidation and the reverse TCA cycle in carbon fixation. [NiFe]-hydrogenases seemed to constitute the preferred strategy to oxidize H2, indicating that besides H2S, H2 could be an essential electron donor in this system. Moreover, the sulfur cycle analysis showed a high abundance and diversity of sulfate reduction genes underpinning the H2S production. This study covers the diversity and metabolic potential of the microbial soil community in Levante bay and adds to our understanding of the biogeochemistry of volcanic ecosystems.
Exploring Compersion: A Study on Polish Consensually Non-Monogamous Individuals and Adaptation of the COMPERSe Questionnaire
Authors: Buczel Klara Austeja , Szyszka Paulina D. , Mara Izu
Published: July 2024

Compersion is a positive emotion experienced in relation to one’s partner’s relationship(s) with other partner(s). Experiencing it is highly desired in communities practicing consensual non-monogamy (CNM), especially polyamory. This article presents the results of a study on compersion on Polish CNM individuals. The main goal of the study was to adapt to the Polish-speaking population the COMPERSe (Classifying Our Metamour/Partner Emotional Response Scale; Flicker et al., 2021), the first standardized quantitative scale designed to measure compersion. The analyses were performed on data obtained from 211 individuals in CNM relationships and on a comparative group of 169 people in monogamous relationships. The results of the confirmatory factor analyses suggested that the three-factor model of the original COMPERSe version did not fit well, leading to further revisions that resulted in a 7-item, two-factor solution with excellent fit, excellent internal consistency, strong divergent and convergent validity, and excellent test–retest stability. The CNM individuals were found to have higher scores on compersion and cognitive empathy and were also less jealous than the monogamous participants. Furthermore, polyamorous individuals experienced more compersion and less aversion to partner’s autonomy than people in open relationships. It was also revealed that compersion indirectly predicted relationship satisfaction by decreasing jealousy and that compersion was, in turn, predicted by cognitive empathy. However, when polyamorous and open relationships were analyzed separately, compersion predicted relationship satisfaction directly, but only in polyamorous relationships; meanwhile, in open relationships, satisfaction was directly predicted by cognitive empathy.
Biotic and abiotic dispersal of a large-seeded keystone genus in Madagascar
Authors: Tonos Jadelys , Rakotoarisoa Hasinavalona , Ramananjato Veronarindra , Randimbiarison Finaritra , Razafindratsima Onja
Published: July 2024

In tropical forests, most plant species rely on frugivorous animals for seed dispersal services. Such mutualisms are imperiled by defaunation, which disproportionately affects large-bodied vertebrates and may impact the interactions of the large-seeded plants they disperse. However, frugivore-mediated seed dispersal (zoochory) may not be the only mechanism ensuring the dispersal of a given plant species. With a focus on large-seeded canopy trees in the genus Canarium in the rainforests of Madagascar, thought to be dispersed by large-bodied lemur species, we investigated the contribution of multiple dispersal mechanisms to the movement of large seeds. Specifically, we (1) examined the potential for dispersal by abiotic factors, such as winds and runoff associated with frequent cyclones, (2) documented the animal species that could effectively contribute to their primary and secondary seed dispersal, and (3) determined how non-lemur and abiotic dispersal compare to the imperiled function of extant, though threatened, lemur primary dispersers. Using field observations and experiments, we found that wind, water, and secondary dispersal can move seeds considerable distances away from the parent plants, though they were less effective at long-distance dispersal than primary dispersers (i.e., large-bodied lemurs). For secondary dispersal, we found that dispersal distance is positively correlated with predation, potentially reducing dispersal effectiveness. Future comparisons with predation of primary or abiotically dispersed seeds will be necessary. Our research highlights the role of understudied mechanisms in the dispersal of large-seeded plants in Madagascar. Understanding the existence and impact of non-lemur dispersers in these imperiled forests can help complete our understanding of the mechanisms that shaped their astounding biodiversity and may mediate their response to ongoing environmental change.
The differences between pure and mixed invasive micropapillary breast cancer: the epithelial–mesenchymal transition molecules and prognosis
Authors: Oz Ozden , Irmak Yuzuguldu Resmiye , Yazici Ayse , Kocatepe Cavdar Demet , Yilmaz Cengiz , Ozturk Mucteba , Duzel Hilal , Gurel Duygu
Published: July 2024

Purpose

Invasive micropapillary carcinoma (IMPC) of the breast is known for its high metastatic potential, but the definition of pure and mixed IMPC remains unclear.

This retrospective cohort study aims to investigate the prognostic significance of the micropapillary component ratio and the expression of critical molecules of epithelial–mesenchymal transition (EMT), including E-cadherin (E-cad), N-cadherin (N-cad), CD44s, and β-catenin (β-cat), in distinguishing between pure and mixed IMPCs.

Methods

We analyzed 100 cases of locally advanced IMPC between 2000 and 2018 and excluded patients who received neoadjuvant chemotherapy. Pure IMPC was defined as having a micropapillary component of over 90%. A comprehensive recording of prognostic parameters was conducted. The IMPC areas were analyzed using the immunohistochemical (IHC) staining method on the microarray set for pure and mixed IMPC patients. Pearson's chi-square, Fisher’s exact tests, Kaplan–Meier analysis, and Cox proportional hazards analysis were employed.

Results

The comparative survival analysis of the entire group, based on overall survival (OS) and disease-free survival (DFS), revealed no significant difference between the pure and mixed groups (P = 0.480, HR = 1.474 [0.502–4.325] and P = 0.390, HR = 1.587 [0.550–4.640], respectively). However, in the pure IMPC group, certain factors were found to be associated with a higher risk of short survival. These factors included skin involvement (P = 0.050), pT3&4 category (P = 0.006), a ratio of intraductal component (> 5%) (P = 0.032), and high-level expression of N-cad (P = 0.020). Notably, none of the risk factors identified for short OS in pure IMPC cases were observed as significant risks in mixed cases and vice versa. Furthermore, N-cad was identified as a poor prognostic marker for OS in pure IMPCs (P = 0.002).

Conclusion

The selection of a 90% ratio for classifying pure IMPCs revealed significant differences in certain molecular and prognostic parameters between pure and mixed groups. Notably, the involvement of N-cadherin in the epithelial–mesenchymal transition (EMT) process provided crucial insights for predicting OS and DFS while also distinguishing between the two groups. These findings strongly support the notion that the pure IMPC subgroup represents a distinct entity characterized by unique molecular characteristics and behavioral patterns.
Ionic liquid interactions with cellulose and the effect of water
Authors: T. Rodrigo Kraemer , Reyes Guillermo , Cartes Marcela , Mejía Andrés , Rojas Orlando J.
Published: July 2024

Ionic Liquids (ILs) have been used to address issues such as recyclability, cost-effectiveness, and tailored thermophysical properties. This is most relevant to recent efforts directed at dissolving cellulose for filament spinning and bioproduct development. Herein, we introduce a simple method to investigate how interactions between cellulose films (roughness, Rh = 37 nm) and ILs specifically 1-butyl-3-methylimidazolium acetate ([bmim][OAc]), 1-butyl-3-methylimidazolium chloride ([bmim][Cl]), 1-ethyl-3-methylimidazolium acetate ([emim][OAc]), and 1-ethyl-3-methylimidazolium chloride ([emim][Cl]), along with their water mixtures (0, 5, and 10 wt%) affect thermophysical properties relevant to cellulose dissolution (surface tension, γ; contact angle, θ; diffusivities, D; and bulk density, ρ) at 363.15 K and 0.1 MPa under argon and air atmospheres. Thermophysical properties relevant to cellulose dissolution were measured at 363.15 K and 0.1 MPa under argon (surface tension, γ, contact angle, θ), and air (diffusivities, D and bulk density, ρ) atmospheres to reveal the effect of the IL counter ions on the involved interactions with water. In general, water increased γ, θ, but reduced D, which supports experimental observations indicating the detrimental effect of water on IL-cellulose interactions. The [emim]+ cation (in [emim][OAc] and [emim][Cl]), produced a lower contact angle with cellulose while the interfacial properties (γ, θ, D) for ILs with the [OAc]− anion were marginally affected by water. By contrast, the two ILs carrying [Cl]− anions exhibited a significant reduction in D (from 11.7$$\cdot {10}^{-13}$$

·

10

-
13

to 2.9$$\cdot {10}^{-13} {m}^{2}{s}^{-1}$$

·

10

-
13

m

2

s

-
1

) in the cation shift from [emim]+ to [bmim]+ at 363.15 K and 0.1 MPa, with 0% water content. Overall, we present a methodical approach rooted in experimental and theoretical approaches to facilitate our understanding of ionic liquids (ILs), especially within the domain of bioprocessing.

Graphical Abstract
Teacher Efficacy, Its Sources, and Implementation in Early Childhood Education
Authors: Pitkäniemi Harri , Hirvonen Riikka , Heikka Johanna , Suhonen Katja
Published: July 2024

The aim of the study is to comprehensively analyze the interrelationships between teacher efficacy, the sources of self-efficacy, and implementation of early childhood education (ECE). The assumption is that according to socio-cognitive theory, source categories predict the self-efficacy of educational staff. According to a few previous research results, knowledge of theories and research in the field of education also contributes to a professional’s self-efficacy. In this study, 202 Finnish ECE teachers evaluated their self-efficacy and its sources (mastery experiences, vicarious experiences, social persuasion, and physiological arousal) as well as their pedagogical planning, implementation, and leadership. A path analysis was conducted to estimate the sources of self-efficacy and active and reactive use of educational research as predictors of teacher self-efficacy, and further, of self-efficacy as a predictor of teachers’ pedagogical planning, implementation, and leadership. The findings showed that mastery experiences, social persuasion, and physiological arousal were positively related to self-efficacy in pedagogical approaches, group management, and child engagement. Intentional use of educational theory and research was positively related to self-efficacy in pedagogical approaches. Furthermore, the quality of pedagogical planning, implementation, and leadership were predicted by high self-efficacy in pedagogical approaches, but implementation also by social persuasion and active use of theory and research.
Sex hormone-binding globulin may explain sex differences for glucose homeostasis and incidence of type 2 diabetes: the KORA study
Authors: Raeisi-Dehkordi Hamidreza , Amiri Mojgan , Rathmann Wolfgang , Zeller Tanja , Adamski Jerzy , Bano Arjola , van der Schouw Yvonne T. , Thorand Barbara , Muka Taulant , Nano Jana
Published: July 2024

Research has indicated that sex hormone-binding globulin (SHBG) is associated with glucose homeostasis and may play a role in the etiology of type 2 diabetes (T2D). While it is unclear whether SHBG may mediate sex differences in glucose control and subsequently, incidence of T2D. We used observational data from the German population-based KORA F4 study (n = 1937, mean age: 54 years, 41% women) and its follow-up examination KORA FF4 (median follow-up 6.5 years, n = 1387). T2D was initially assessed by self-report and validated by contacting the physicians and/ or reviewing the medical charts. Mediation analyses were performed to assess the role of SHBG in mediating the association between sex (women vs. men) and glucose- and insulin-related traits (cross-sectional analysis) and incidence of T2D (longitudinal analysis). After adjustment for confounders, (model 1: adjusted for age; model 2: model 1 + smoking + alcohol consumption + physical activity), women had lower fasting glucose levels compared to men (β = -4.94 (mg/dl), 95% CI: -5.77, -4.11). SHBG levels were significantly higher in women than in men (β = 0.47 (nmol/l), 95% CI:0.42, 0.51). Serum SHBG may mediate the association between sex and fasting glucose levels with a proportion mediated (PM) of 30% (CI: 22–41%). Also, a potential mediatory role of SHBG was observed for sex differences in incidence of T2D (PM = 95% and 63% in models 1 and 2, respectively). Our novel findings suggest that SHBG may partially explain sex-differences in glucose control and T2D incidence.
On the Scaling of the Cubic-to-Tetragonal Phase Transformation with Displacement Boundary Conditions
Authors: Rüland Angkana , Tribuzio Antonio
Published: July 2024

We provide (upper and lower) scaling bounds for a singular perturbation model for the cubic-to-tetragonal phase transformation with (partial) displacement boundary data. We illustrate that the order of lamination of the affine displacement data determines the complexity of the microstructure. As in (Rüland and Tribuzio in ESAIM Control Optim. Calc. Var. 29:68, 2023) we heavily exploit careful Fourier space localization methods in distinguishing between the different lamination orders in the data.
Comment on Aurélien Drezet’s Defense of Relational Quantum Mechanics
Authors: Lawrence Jay , Markiewicz Marcin , Żukowski Marek
Published: July 2024

Aurélien Drezet has attempted in Found. Phys. 54(1), 5 (2023) to defend Relational Quantum Mechanics (RQM) against our recent critique, entitled Relational Quantum Mechanics is incompatible with quantum mechanics, published in Quantum 7, 1015 (2023). Drezet not only misrepresents our work, but he also misconstructs the very theory (RQM) that he claims to defend.
Use-Wear Analysis of Obsidian and Other Volcanic Rocks: An Experimental Approach to Working Plant Resources
Authors: Brito-Abrante Idaira , Rodríguez-Rodríguez Amelia
Published: July 2024

This experimental study aims to contribute to functional analysis research on tools which specifically served to work wood and non-woody plants. They were made of obsidian and other volcanic rocks (basalt, trachyte, and phonolite) characterised by an amorphous matrix and phenocrysts of different number and size. In spite of prior functional analysis research resorting to these raw materials, there remain gaps in our understanding of specific activities. The work thus focused on working different types of wood from the Canary Island as well as on harvesting cereals. It is likewise centred on craftwork, especially regarding certain rarely studied contact materials such as palm leaves and rushes. The results reveal use-wear differences stemming from working woody and non-woody plants with both obsidian and other volcanic rocks. A special attention was given to the identification and description of the different features depending on the raw materials and the characteristics of their knapped surfaces. Identifying the combination of attributes has been essential to attain more accurate diagnostics. There are limits to each of the types of raw materials. The surfaces of obsidian are easier to observe and allow more specific identifications. In turn, the heterogeneous surfaces of volcanic rocks with phenocrysts that require more to time to develop diagnostic traces render use-wear amongst these types of rocks more difficult to observe. It is possible to distinguish longitudinal and transversal actions between woody and non-woody plants on every rock. Actions related to basketry, such us splitting and scraping, are more complicated to identify. The state of the worked plant (dry or fresh) and the time of use are key factors to consider in each case.
Comparative analysis of AnaLig Sr01 and Sr Resin methods for 210Pb determination in tobacco using TriCarb 3100 TR spectrometry: a statistical approach to accuracy and efficiency
Authors: Dulanská Silvia , Silliková Veronika , Burganová Andrea , Bujdoš Marek , Trnka Michal , Kosnáč Daniel , Pánik Ján
Published: July 2024

This study aims to statistically compare two methods for determining 210Pb in tobacco: the molecular recognition sorbent method (AnaLig Sr01) and the extraction chromatography sorbent method (Sr Resin). The TriCarb 3100 TR liquid scintillation spectrometer was used to measure and determine 210Pb activity in the tobacco solution. Statistical analysis confirmed the accuracy and precision of the 210Pb measurements, with high detection efficiencies of 82% for both AnaLig Sr01 and Sr Resin. The linear model demonstrated that the residuals followed the Gaussian model, without any autocorrelation or trend. Paired t tests showed consistent results across all methods, and all solid-phase extraction methods proved efficient for 210Pb separations in tobacco samples. These findings provide support for the suitability of both methods and lay a foundation for future articles on tobacco and cigarette samples.
A Note on the Distribution of the Extreme Degrees of a Random Graph via the Stein-Chen Method
Authors: Malinovsky Yaakov
Published: July 2024

We offer an alternative proof, using the Stein-Chen method, of Bollobás’ theorem concerning the distribution of the extreme degrees of a random graph. Our proof also provides a rate of convergence of the extreme degree to its asymptotic distribution. The same method also applies in a more general setting where the probability of every pair of vertices being connected by edges depends on the number of vertices.
Are Women Politicians Kind and Competent? Disentangling Stereotype Incongruity in Candidate Evaluations
Authors: Rohrbach Tobias
Published: July 2024

Academia and political campaigners conventionally cast gender stereotypes as an electoral liability for women in politics. Incongruent stereotype expectations place women in a double-bind where they either fail the social demands of political leadership or they breach gender norms related to femininity—with potential backlash due to stereotype violation in both cases. Two decades of research offer conflicting conclusions regarding the role of stereotype incongruity in candidate evaluations and its electoral consequences for women in politics. This paper theoretically revisits and empirically tests core assumptions of stereotype incongruity as a driver of gender biases in political communication. In a series of four online survey experiments, this study examines incongruity in trait expectations (study 1), trait inferences (studies 2 and 3), and trait evaluations (study 4). Results show that voters expect and infer incongruity in candidate traits for women and men politicians only in few but notable cases. Moreover, voters punish candidates of both gender groups similarly for displaying stereotypically undesirable traits but reward female politicians more strongly for displaying desirable communal traits. The findings have important implications for the understanding of persistent biases that women face in electoral politics.
Effects of Two Early Parenting Programmes on Child Aggression and Risk for Violence in Brazil: a Randomised Controlled Trial
Authors: Murray Joseph , Martins Rafaela Costa , Greenland Melanie , Cruz Suélen , Altafim Elisa , Arteche Adriane Xavier , Cooper Peter J. , Domingues Marlos Rodrigues , Gonzalez Andrea , Kramer Fiala Machado Adriana , Murray Lynne , Oliveira Isabel , Santos Iná , Soares Tâmara Biolo , Tovo-Rodrigues Luciana , Voysey Merryn
Published: July 2024

Violence is a major public health problem globally, with the highest rates in low- and middle-income countries (LMICs) in the Americas and southern Africa. Parenting programmes in high-income countries can diminish risk for violence, by reducing risk factors such as child aggression and harsh parenting, and increasing protective factors such as child cognitive development and school readiness. However, there is critical need to identify low-cost programmes with replicable benefits that work in real-world LMICs contexts. A three-arm, randomised, single-blind trial evaluated effects of two low-cost, group-based parenting programmes recommended for LMICs (ACT: Raising Safe Kids; DBS: dialogic book-sharing) on child aggression (primary outcome), child development, parenting, maltreatment, and stress. Participants were 369 children with medium–high levels of aggression (mean age 3.1 years at baseline) in poor households. Interventions were implemented in city health and education services in southern Brazil. Maternal reports, filmed observations, child tasks, and hair cortisol were assessed at baseline, 1-month post-intervention, and 8-month follow-up. Intention-to-treat analyses compared each of ACT and DBS with a control group. Three hundred sixty-eight (99.7%) participants completed follow-up assessments 8 months after the interventions. There was no effect of ACT (standardised mean difference, SMD 0.11, 95% CI − 0.05, 0.27) or DBS (SMD 0.05, 95% CI − 0.11, 0.21) on the primary outcome of child aggression. ACT reduced harsh parenting behaviour post-intervention (SMD − 0.23; 95% CI − 0.46, − 0.01), but not at follow-up. DBS improved book-sharing practices at both time points (e.g., maternal sensitivity at follow-up SMD 0.33; 95% CI 0.08, 0.57). There were no benefits of either programme for other parenting, child development, or stress outcomes. Two parenting programmes in Brazil had small effects on parenting practices but did not reduce child aggression or several other important risk/protective factors for violence. Effective early interventions that reduce violence in real-world LMIC settings are highly desirable but may be challenging to achieve.
Indeterministic grounding
Authors: Wygoda Cohen Shlomit
Published: July 2024

Grounding is sometimes thought of as metaphysical causation. If we take this analogy seriously, given the possibility of indeterministic causation we have at least prima facie reason to accept the possibility of indeterministic grounding. However, prima facie reasons are defeasible and there may be stronger reasons to reject this possibility. This paper sets out to critically examine this mostly overlooked possibility. After introducing the possibility of indeterministic grounding as analogous to indeterministic causation (Sect. 1), I clarify further the notion of indeterministic grounding by relating it to failure of supervenience (Sect. 2). I then construct an argument for the logical or conceptual possibility of indeterministic grounding, and defend it against a few possible objections (Sect. 3). Next, I explore and reject various reasons for dismissing the possibility of indeterministic grounding (Sects. 4 and 5). And I conclude by considering why philosophers almost universally overlook or rule out the possibility of indeterministic grounding, by examining the case of physicalism (Sect. 6).
Optimizing anterior urethral stricture assessment: leveraging AI-assisted three-dimensional sonourethrography in clinical practice
Authors: Feng Chao , Lu Qi-Jie , Xue Jing-Dong , Shu Hui-Quan , Sa Ying-Long , Xu Yue-Min , Chen Lei
Published: July 2024

Purpose

This investigation sought to validate the clinical precision and practical applicability of AI-enhanced three-dimensional sonographic imaging for the identification of anterior urethral stricture.

Methods

The study enrolled 63 male patients with diagnosed anterior urethral strictures alongside 10 healthy volunteers to serve as controls. The imaging protocol utilized a high-frequency 3D ultrasound system combined with a linear stepper motor, which enabled precise and rapid image acquisition. For image analysis, an advanced AI-based segmentation process using a modified U-net algorithm was implemented to perform real-time, high-resolution segmentation and three-dimensional reconstruction of the urethra. A comparative analysis was performed against the surgically measured stricture lengths. Spearman’s correlation analysis was executed to assess the findings.

Results

The AI model completed the entire processing sequence, encompassing recognition, segmentation, and reconstruction, within approximately 5 min. The mean intraoperative length of urethral stricture was determined to be 14.4 ± 8.4 mm. Notably, the mean lengths of the urethral strictures reconstructed by manual and AI models were 13.1 ± 7.5 mm and 13.4 ± 7.2 mm, respectively. Interestingly, no statistically significant disparity in urethral stricture length between manually reconstructed and AI-reconstructed images was observed. Spearman’s correlation analysis underscored a more robust association of AI-reconstructed images with intraoperative urethral stricture length than manually reconstructed 3D images (0.870 vs. 0.820). Furthermore, AI-reconstructed images provided detailed views of the corpus spongiosum fibrosis from multiple perspectives.

Conclusions

The research heralds the inception of an innovative, efficient AI-driven sonographic approach for three-dimensional visualization of urethral strictures, substantiating its viability and superiority in clinical application.
A survey on popularity bias in recommender systems
Authors: Klimashevskaia Anastasiia , Jannach Dietmar , Elahi Mehdi , Trattner Christoph
Published: July 2024

Recommender systems help people find relevant content in a personalized way. One main promise of such systems is that they are able to increase the visibility of items in the long tail, i.e., the lesser-known items in a catalogue. Existing research, however, suggests that in many situations today’s recommendation algorithms instead exhibit a popularity bias, meaning that they often focus on rather popular items in their recommendations. Such a bias may not only lead to the limited value of the recommendations for consumers and providers in the short run, but it may also cause undesired reinforcement effects over time. In this paper, we discuss the potential reasons for popularity bias and review existing approaches to detect, quantify and mitigate popularity bias in recommender systems. Our survey, therefore, includes both an overview of the computational metrics used in the literature as well as a review of the main technical approaches to reduce the bias. Furthermore, we critically discuss today’s literature, where we observe that the research is almost entirely based on computational experiments and on certain assumptions regarding the practical effects of including long-tail items in the recommendations.