bluuebunny/crossref_metadata_2025 huggingface dataset:
Paronychie et formation de tissu granuleux au cours d’un traitement par isotrétinoïne
Authors: De Raeve L. , Willemsen M. , De Coninck A. , Roseeuw D.
Published: October 2009

This paper reports on the association of two uncommon side effects of isotretinoin therapy for cystic acne: paronychia and excess granulation tissue in the nail sulci. An explanation for these side effects is suggested, but the exact pathogenesis remains obscure.
Density of Dopa-Positive Melanocytes in Dyschromatosis symmetrica hereditaria
Authors: Hata Seiichiro , Yokomi Ikuko
Published: October 2009

Dyschromatosis symmetrica hereditaria, one of the hereditary diseases characterized by the presence of pigmented and hypopigmented spots on the extremities, was studied by the splitting dopa stain on the hypopigmented area. There were 190 ± 58/mm2 dopa-positive cells, i.e. less than the normal value of the Japanese population. This suggests that the pigment anomaly in this disease may be due to the small number of melanocytes.
Ring Size Measurement of the Digits in Females Suffering from Generalized Scleroderma (Acrosclerosis)
Authors: Serup Jørgen
Published: October 2009

Measurements of the ring size (circumference in millimeters) of the middle phalanx in 22 females suffering from generalized scleroderma (acrosclerosis) were carried out and compared to control measurements in 22 age-matched healthy females. The ring size was increased (p < 0.01) in the patients (mean 52.8 mm; range 45–61) as compared to the controls (mean 49.4 mm; range 46–52). Ring size measurements correlated well (r = 0.71; p < 0.001) with ultrasound measurement of soft tissue thickness over the middle phalanx. Ring size was larger (p < 0.001) in a group of healthy men as compared to female controls. Ring size was not correlated to age in healthy females (r = 0.06; n.s.), whereas it was in 19 healthy men studied (r = 0.78; p < 0.001). The normal range (mean ± 2 SD) for ring size in females was 45.5–53.3 mm; in males ≤ 60 years of age, the range was 48.5–59.2 mm. It is concluded that ring size is suited to quantify soft tissue changes of the digits in acrosclerosis. This method has the advantage of being simple.
Comparison of Oxatomide and Clemastine in the Treatment of Chronic Urticaria
Authors: Beck Hans-Iver , Cramers Marie , Herlin Troels , Søndergaard Ib , Zachariae Hugh
Published: October 2009

A double-blind trial comparing a new antihistaminic agent (oxatomide) with clemastine was carried out in 30 patients with chronic urticaria. The study included over-all clinical assessment by patient and clinician as well as determination of excretion of 1,4-me-thylimidazoleacetic acid determined by a reversed-phase ion-pair high-performance liquid chromatographic method. It was found that the effect of oxatomide was equal to that of clemastine.
Comparison of the Short-Duration Dithranol and Dithrocream® Therapy in the Treatment of Psoriasis
Authors: Fräki Jorma E. , Neittaanmäki Heikki , Väätäinen Niilo
Published: October 2009

Short-duration dithranol therapy (SDDT) was compared to Dithrocream® therapy in an open trial for the treatment of psoriasis. SDDT is based on the application of highly concentrated (1–2%) dithranol (anthralin) for a short period of time (10–20 min) and appeared to be clearly less staining and more comfortable than Dithrocream (0.1–0.5%). Both treatment methods appeared to be clinically effective; the SDDT method was slightly more effective than Dithrocream in this study.
Les trichomatoses
Authors: Pierard G.E. , Renkin A. , Pierard-Franchimont C.
Published: October 2009

A 4 year-old boy presented an acute pruriginous dermatitis of the hands, forearms and abdomen. A skin surface biopsy revealed numerous trichomes, small prickles present on plants. These trichomes were those of prickly pears and stuck deeply in the skin, inducing an inflammatory reaction known as Sabra dermatitis. A number of plant dermatitides are due to the presence of trichomes such as those due to linden, primula, wild rose or nettle.
Plasma Concentrations of Beta-Carotene and Canthaxanthin during and after Stopping Intake of a Combined Preparation
Authors: Meyer J.C. , Grundmann H.P. , Seeger B. , Schnyder U.W.
Published: October 2009

During 17 days two groups of 6 and 8 volunteers of the Department of Dermatology ingested 4 and 6 capsules per day of carotenoids (10 mg β-carotene + 15 mg canthaxanthin per capsule; Phenoro). Heparinized blood was collected twice a week until day 21 and then weekly until day 77. Concentrations of β-carotene and canthaxanthin in plasma were analyzed by high-performance liquid chromatography during 77 days. Plasma levels of carotenoids were higher in group 2 (6 capsules) than in group 1 (4 capsules) but reached maximum concentrations within the same time. Hence, therapeutic plasma levels of β-carotene were reached earlier in group 2. According to blood levels, group 2 could be clearly divided in low and high responders. In contrast to canthaxanthin, β-carotene exhibited a biphasic decline in both groups, with a monophasic asymptotic decrease which was expressed clinically by a pronounced orange to yellow pigmentation of the skin.
Correlation of Serum Anti-Basement Membrane Zone Antibody and Malignancy in Bullous Pemphigoid
Authors: Ahmed Razzaque , Amerian Mary L.
Published: October 2009

73 patients with bullous pemphigoid were studied to examine the association between serum anti-basement membrane zone (anti-BMZ) antibody and malignancy. Indirect immunofluorescence (IIF) was performed on the sera. 37 patients had positive IIF for anti-BMZ antibodies, ranging in titer from 1:20 to 1:10,230. On a follow-up of 7–41 months (mean 22 months), only 3 patients (8%) had malignancies (endometrium, bladder, squamous cell carcinoma of the skin). 36 patients had negative IIF for anti-BMZ antibodies. On a follow-up of 5–43 months (mean 16 months), 3 patients (8%) had malignancies (breast, colon, endometrium). No correlation between the presence or absence of anti-BMZ antibody in the serum and the development of malignant disease was observed.
Genetic Susceptibility in Pityriasis versicolor
Authors: Hafez M. , El-Shamy S.
Published: October 2009

300 patients with pityriasis versicolor, 168 males and 132 females, of different ages were included in this study. Each was subjected to a detailed structured questionnaire. All the available relatives had been examined. Pedigrees were constructed and segregation analysis was done using the mathematics of population genetics. The collected data showed genetic susceptibility which is inconsistent with any of the single gene defects but fulfill the criteria of multifactorial (genetic-environmental) inheritance. The heritability was estimated to be 22.2% in the first-degree relatives.
Soft-X-Ray Therapy in Bowen’s Disease and Erythroplasia of Queyrat
Authors: Blank Armin A. , Schnyder Urs W.
Published: October 2009

The therapeutic results obtained with soft-X-ray irradiation on 77 lesions in 52 patients are reported. 35 males (67.3%) and 17 females (32.7%) were treated. Clinical and aistological features revealed Bowen’s disease in 73 cases (94.8%) and erythroplasia of Queyrat in 4 cases (5.2%). The primary healing was rated as 100% in all cases up to 6 months after a cumulative dosage of 3,200–5,000 R. 2 cases with a genital localization (2.6% of all sites and 11.1% of anogenital localizations) relapsed after 8 and 16 months, respectively. The follow-up period ranged from 1 to 11 years with a mean of 3 years. In order not to miss the late recurrences, the oncologic follow-up is taken care of by the Dermatology Department of the Zurich University Hospital during 10 years, or longer in some cases. Association with a malignant internal tumour (larynx, bronchi, anus) was found in 3 patients (5.8%).
Combined UVB and UVA Phototherapy of Atopic Eczema
Authors: Midelfart Kjell , Stenvold Svein-Erik , Volden Gunnar
Published: October 2009

The effect of combined UVB-UVA treatment in a group of 23 patients with severe atopic eczema was compared to UVB therapy alone in 33 patients. Mean age and number of treatments were approximately the same in the two groups. With UVB-UVA treatment, 48% achieved complete remission and in another 48% good improvements were obtained as compared to 27 and 58%, respectively, in the group treated with UVB alone. A few failures were recorded in the UVB group. Some possible explanations for the better effect of the combined UVB-UVA treatment are given.
Myosite proliférative post-traumatique
Authors: Pierard G.E.
Published: October 2009

A clinical and histological study of one case of proliferative myositis is reported. The relationship between that entity, and dermatofibromas and Dupuytren’s disease are discussed.
Dermatomyositis Associated with Chronic Myelogenous Leukemia
Authors: Tierney, Jr. Lawrence M. , Jensen Barbara , Schwartz Robert A.
Published: October 2009

Dermatomyositis and polymyositis have been well established in association with malignant neoplastic disease. Most commonly, this association has been noted in patients with solid tumors rather than in patients with neoplasms of hematopoietic origin. We describe here a patient with chronic myelogenous leukemia who developed typical dermatomyositis, which responded to therapy with corticosteroids. This concurrence has been reported in only one previous patient to our knowledge. The nature and implications of the association of dermatomyositis and neoplasia are discussed.
Treatment of Alopecia areata with Diphencyprone
Authors: Orecchia G. , Rabbiosi G.
Published: October 2009

26 patients with alopecia areata were treated topically with Diphencyprone. 10 had alopecia universalis, 7 alopecia totalis and 9 had alopecia areata. The treatment lasted from 4 to 14 months. In 13 patients a little response was obtained; only in 1 case it was satisfactory. Factors that appear to influence these results are discussed.
Treatment of Cutaneous Infection due to Mycobacterium ulcerans
Authors: Song M. , Vincke G. , Vanachter H. , Benekens J. , Achten G.
Published: October 2009

A Zairese patient with an extensive ulceration on the left foot due to Mycobacterium ulcerans was successfully treated with antibiotics and Debrisan®. The diagnosis and treatment are discussed.
Onychotillomania
Authors: Sait Mohammed Ameen , Ready B.S.N. , Garg B.R.
Published: October 2009

2 interesting cases of onychotillomania associated with depressive neurosis and delusion of infestation, respectively, are reported with a brief review of the literature.
Primary Cutaneous Cryptococcosis
Authors: Baes Herman , Van Cutsem Jan
Published: October 2009

A 53-year-old man, a pigeon fancier, with long-standing asthma, treated for years with systemic corticosteroids, developed a fast-growing mass on his right wrist. The diagnosis of cryptococcosis was established by histology and culture of tissue which yielded Cryptococcus neoformans. Oral treatment with ketoconazole for 3 months resulted in a complete cure with residual hyperpigmentation and minute scars. During a 10-month follow-up, the patient was free of recurrences.
Larva currens following Systemic Steroid Therapy in a Case of Strongyloidiasis
Authors: Orecchia G. , Pazzaglia A. , Scaglia M. , Rabbiosi G.
Published: October 2009

The authors report a case of larva currens following systemic steroid administration for acute contact eczema. The patient was found affected with subclinical strongyloidiasis. Strongyloides is not very common in Northern Italy; it is occasionally diagnosed from stool samples from patients complaining of persisting itching.
Epidermolyse bulleuse dystrophique albopapuloïde autosomique recessive
Authors: Ramelet A.-A. , Boillat C.
Published: October 2009

Albopapules are usually considered as pathognomonic lesions of Pasini’s epidermolysis bullosa, which is dominantly transmitted. Herein, we are reporting 3 cases of recessively inherited epidermolysis bullosa with albopapules. The clinical, histological and ultrastructural features are described. It is concluded that the presence of albopapules is not necessarily a safe criterion for the diagnosis of Pasini’s epidermolysis bullosa.
Les élastolyses héréditaires
Authors: Ledoux-Corbusier M.
Published: October 2009

Several inherited syndromes characterized by abnormal elastic fibers decreased in number and size could be collected under the heading of inherited elastolysis. This morphological concept does not prejudge the causal mechanisms of the elastolysis involving dermis and/or other organs. The elastic fibers anomalies result mainly from elastin crosslinking defects, developmental disturbances or excessive proteolysis.
Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo
Authors: Betterle C. , Caretto A. , De Zio A. , Pedini B. , Veller-Fornasa C. , Cecchetto A. , Accordi F. , Peserico A.
Published: October 2009

The frequency of autoimmune disorders was determined in 373 vitiligo patients and in controls matched for sex, age and race. Vitiligo patients had an increased frequency of clinical autoimmune diseases of thyroid (7.5%), stomach (0.8%), parathyroid (1%), adrenal gland (1.3%). Vitiligo patients, without clinical signs of overt autoimmune diseases, also had a statistically significant increase in the frequency of gastric parietal cell (p < 0.001), thyroid microsomal (p < 0.05) and adrenal autoantibodies (p < 0.05). This increased incidence of autoimmune manifestations was correlated with the duration of vitiligo. Furthermore in 94% of the patients with parietal cell autoantibodies a gastric biopsy showed atrophic gastritis. In addition, in 48% of the patients with thyroid microsomal autoantibodies and in 2 out of 6 patients with adrenal autoantibodies without overt diseases at the beginning of the study, the functional investigation of the target organs during the follow-up allowed the detection of the presence or that of the subsequent development of clinical or subclinical dysfunction.
Clinical Significance of Lymphocyte Responsiveness to Scleroderma-Inducing Glycosaminoglycan-Associated Antigen in Systemic Scleroderma
Authors: Tamura Taeko , Ishikawa Hidekazu
Published: October 2009

Twenty-nine patients with systemic scleroderma (SSD), whose lymphocytes significantly responded to a scleroderma-inducing glycosaminoglycan-associated antigen (stimulation index ≥ 1.7), were separated into the two groups of marked and moderate responses, according to the mitogenic response of their peripheral lymphocytes. A marked response, with a [3H]-thymidine uptake of +3 SD over the mean of unstimulated SSD lymphocytes, was seen in severely affected patients with a high OKT4/OKT8 ratio. In contrast, the lymphocytes of patients with benign disease responded moderately to the antigen, showing lower thymidine uptake by both unstimulated and stimulated lymphocytes. This latter group had a high frequency of elevated anti-nRNP antibody.
Season Dermatitis ex insectis Caused by Stings of Sclerodermus domesticus
Authors: Mohar N. , Dujmović R. , Uremović Vera
Published: October 2009

Case history of five members from the same family is reported. They developed papulourticarial pruritic rash on the skin of their torsos and extremities during their summer stay in an old family house. The cause was an insect determined as Sclerodermus domesticus, known for its parasitism on larvae of a wood pest. Examination of the furniture revealed a lot of holes typical for these pests. Cases of stings of these insects have not been described in Yugoslavia till now.
Ambulatory Treatment of Psoriasis with Dithranol Sticks A Novel Paraffin Formulation
Authors: Brandt H. , Gordin A. , Mustakallio K.K.
Published: October 2009

The efficacy and tolerability of a novel stiff dithranol stick (Ditrastick®, Orion, Espoo, Finland) were evaluated in an open multicenter trial comprising 121 outpatients with limited psoriasis of the plaque type. Daily treatment was startet with 1.5% dithranol sticks and continued in most patients with 3% sticks after 2 weeks. An excellent or good result was obtained in over half of the patients. Early irritation of a rather narrow rim of the skin surrounding the lesions was common, but only about 10% of the patients discontinued the trial due to this side effect. Paraffin-based dithranol sticks thus enable ambulatory treatment of chronic plaque psoriasis in the areas of predilection. Dithranol is stable in this novel preparation for at least 3 years.
Vegetating Iodides after an Intravenous Pyelogram
Authors: Lauret Ph. , Godin M. , Bravard P.
Published: October 2009

A 68-year-old woman treated by hemodialysis for chronic renal failure received 30.4 g iodine for an intravenous pyelogram. Three days later, she was covered by aseptic pustules which quickly evolved into vegetating masses on the face. Skin pathology showed dermo-epidermal necrosis with dermal polymorphonuclear infiltrates, sometimes pycnotic, and necrotizing vasculitis. Serum iodine was far above normal values. Hemodialysis and local care resulted in good healing within 1.5 month. Four similar cases occurring in patients with renal failure are mentioned in literature.
Study of Psoriatic Epidermal Cell Kinetics and Cell Death after Oral Methotrexate
Authors: Newton J.A. , Camplejohn R.S. , Bowyer C. , McGibbon D.H. , Wright N.A.
Published: October 2009

Epidermal cell proliferation in psoriasis was studied after oral methotrexate using tritiated uridine. Psoriatic enteropathy has in the past been reported to reduce the absorption of methotrexate administered orally but this study showed that the onset of inhibition of mitosis and DNA synthesis occurred at the same time as after intramuscular administration of the drug. The cell kinetic data indicate that cells were blocked at the G1/S interface, and the kinetics of inhibition are discussed in terms of their implications for the mode of action of methotrexate in psoriasis. Considerable numbers of dead cells were seen in the epidermis from 6 to 24 h after oral methotrexate. The mode of action of methotrexate in psoriasis is currently unknown but whatever other actions it may have, any global hypothesis of its action will have to incorporate a flux to epidermal cell death.
Dermatomyositis with Prominent Mucinous Skin Change
Authors: Igarashi Minoru , Aizawa Harumi , Tokudome Yasuko , Tagami Hachiro
Published: October 2009

Although there is occasionally remarkable accumulation of mucin in the skin lesion of dermatomyositis, no special attention has been paid in regard to mechanisms underlying it. We carried out histochemical and biochemical studies on materials obtained from one case of dermatomyositis, who showed the presence of abundant mucinous material stainable with alcian blue between the collagen bundles throughout the lesional dermis. The major component of the ground substance was identified to be hyaluronic acid. The activity of N-acetyl-β-glucosaminidase, exoglycosidase that degrades hyaluronic acid in serum of the patient, was equivalent to that of controls. However, heparan sulfate was greatly increased in the urine of the patient in comparison with that of the normal controls in which the major components were chondroitin 4-sulfate and chondroitin 6-sulfate. We think that the increase of hyaluronic acid in the lesional dermis is due to an excess production by the fíbroblasts under some immunological stimulation, although its relation to the increased heparan sulfate excretion into the urine of the patient is obscure.
Atopic Cataracts in a Japanese Population
Authors: Uehara Masami , Amemiya Tsugio , Arai Mari
Published: October 2009

Atopic cataract was observed in 19 (12.4%) of 153 Japanese adolescent and young adult patients with atopic dermatitis. Of the 19 patients, 4 had gross cataract which produced impairment of vision, and 15 had incipient cataract which was not accompanied by visual impairment. Cataracts occurred most frequently in patients with severe atopic dermatitis. Cataract development had no relationship to the distribution of skin lesions, clinical course of dermatitis, personal history of respiratory atopy, serum IgE levels, or concomitant ichthyosis vulgaris.
Acquired Hypertrichosis lanuginosa: A Case Report
Authors: Delfino Mario , Suppa Francesco , Piccirillo Angelo , Martellotta Donata , Monfrecola Giuseppe
Published: October 2009

The authors present a patient with hypertrichosis lanuginosa acquisita without associated malignancy.
Les levures dans les ulcères de jambe
Authors: Dereume J.L.
Published: October 2009

Cultures on Sabouraud medium from the leg ulcers of 50 patients were obtained: 24% of the lesions were infected by Candida species. The risk factors are analyzed. The disappearance of the yeasts after topical treatment does not consistently speed up the healing.
Syndrome basocellulaire
Authors: Dereume J.L. , de Sélys R. , Bataille S.
Published: October 2009

A 90-year-old female presented with multiple nevoid basal cell epitheliomas, skeletal defects and jaw cysts. The syndrome is briefly revisited.
A Case of Squamous Cell Carcinoma Treated by Intralesional Injection of Oil Bleomycin
Authors: Tanigaki Takehiko , Endd Hidehiko
Published: October 2009

The case of a 70-year-old man with squamous cell carcinoma on the glabella which markedly responded to intralesional injections of oil bleomycin (to a total dose of 115 mg) is reported. Adverse reactions to oil bleomycin comprised fever of 37–38°C immediately after injection, local redness, and swelling and induration of 1–2 months’ duration in the marginal area of the injection site. Biopsy of the induration revealed oleogranuloma. The advantages of oil bleomycin are that this dosage form of bleomycin is not accompanied by severe systemic toxicities such as pulmonary fibrosis and that the effective dose is smaller than that of aqueous bleomycin.
Vehikelabhängigkeit der Harnstoffpenetration in die menschliche Haut
Authors: Wohlrab W.
Published: October 2009

Prerequisite to any efficiency of urea in the skin is its penetration into the different skin layers. In addition to the differences in the reactivity of the skin, the ointment base is the most important factor for the intensity and the course of urea penetration. For the penetration of urea into the human skin a strong vehicle dependence can be proved. On the basis of a different penetration kinetics of urea from O/W and W/O emulsions, various efficiencies can be deduced with regard to the penetration promotion of drugs or the increase of the water-binding capacity of the horny layer. The significance of these findings for the use of urea in the external therapy is being discussed.
Exploration et thérapeutique des lymphomes cutanés à cellules T
Authors: Le T. , Pierard G.E. , Pierard-Franchimont C. , de la Brassinne M. , Lapière Ch.M.
Published: October 2009

We report the observation of 16 cases of cutaneous T cell lymphoma consisting of 11 cases with mycosis fungoides and 5 cases with high-grade malignant lymphomas. A standardized clinical evaluation is proposed for patients with low-grade malignant lymphomas for whom we favor the use of non-aggressive therapeutic regimens. High-grade lymphomas need a more complete systemic exploration. Treatment of cutaneous T cell lymphomas should be started with the least aggressive antineoplastic therapy.
Determination of Zinc, Copper, Manganese, and Iron in Blood from Patients with Light-Sensitive Skin Diseases
Authors: Horkay Irene , Teherani D.K. , Altmann H. , Krajczár J.
Published: October 2009

It is known that some trace elements have an influence on the repair of UV light induced DNA damage. We have detected certain alterations in the excision repair of patients with photodermatoses. In these investigations of screening character the levels of zinc, copper, manganese, and iron were measured by means of atomic absorption spectrophotometry in the whole blood of 31 patients with polymorphic light eruption and 27 patients with cutaneous porphyrias. In active stage of polymorphic light eruption decreased zinc, copper, and iron concentrations and an increased manganese content were found. In remission only the zinc level was lower. In the active stage of cutaneous porphyrias a decreased zinc and iron content as well as an increased manganese level could be detected. A presumable connection between the findings and the rate of the excision repair is discussed.
A Case of Epidermodysplasia verruciformis (Lewandowsky-Lutz, 1922) with Skin Cancer: Histopathology of Malignant Cutaneous Changes
Authors: Tanigaki Takehiko , Endo Hidehiko
Published: October 2009

Histopathology of tumors which occurred on the face of a 34-year-old man with epidermodysplasia verruciformis was studied. The following three different types of histological changes were recognized in the tumors: (1) intraepidermal initial changes; (2) Bowen-like changes, and (3) squamous cell carcinoma. Carcinogenetic processes in this case were compatible with those reported by Todaro et al. in 1966, in which case tumors were caused in vitro by SV40 virus. According to their results, initial transformed cells were observed to occur at the lower layer of the epidermis. It seemed likely that viral infection occurred at the epidermal lower layer and immediately the infected cells divided and some of them changed to transformed cells which then abnormally proliferated to show a malignant feature. Similar histological changes were recognized and viral oncogenesis was suggested in this case too.
Oral Manifestations of Sweet’s Syndrome
Authors: Driban Nelson E. , Alvarez Martin A.
Published: October 2009

A case of a 38-year-old male with the diagnosis of Sweet’s Syndrome is reported. The most significant feature of the patient was manifested by serious lesions in the oral mucosa which persisted throughout the course of the disease. They only improved after the administration of prednisone. Special emphasis is made on the characteristics of the oral manifestations of Sweet’s syndrome since they have not been described in detail in the literature.
The Epidermal Merkel Cell Is an Epithelial Cell
Authors: Saurat J.H. , Didierjean L.
Published: October 2009

TROMA 1 a monoclonal antibody against cytokeratin, was found to react with epidermal Merkel cells. This demonstrates the epithelial origin of MC.
Porphyria cutanea tarda in Beta-Thalassemia Trait Carriers
Authors: Gibertini P. , Rocchi E. , Cassanelli M. , Pietrangelo A. , Ventura E.
Published: October 2009

The authors report 5 cases of porphyria cutanea tarda (PCT) occurring in carriers of the beta-thalassemia trait. This hematologic condition may be responsible for the development of liver damage resulting in siderosis, higher susceptibility to hepatitis B virus infection, and the earlier appearance of clinical features of PCT. Consequently, the authors propose chelation therapy with long-term subcutaneous desferioxamine infusions.
2 Cases of Hereditary Palmoplantar Keratoderma
Authors: Tezuka Tadashi
Published: October 2009

2 cases of hereditary palmoplantar keratoderma (Unna-Thost type and keratosis palmoplantaris striata s. linearis type) are reported. In the former, moderate hyperkeratosis and a partial decrease in the stratum granulosum were histologically seen. Keratohyalin granules in the uppermost cell layer of the stratum granulosum were positively stained with the Pauly reagent, though the stratum granulosum consisted of three or four cell layers in the hematoxylin-eosin-stained specimen. Electron microscopically, keratohyalin granules in the lower two or three cell layers of the stratum granulosum were less electron-dense than normal and were granular in appearance, but those in the uppermost cell layer were normal in electron density and in appearance. This case indicates that human keratohyalin granules could consist of a less electron-dense component and an electron-dense amorphous component, and the Pauly-positive substance could be electron-dense and amorphous, and the basophilic material in the hematoxylin-eosin specimen could be less electron-dense and granular under electron microscopy. In the latter, remarkable orthokeratotic hyperkeratosis and hypergranulosis were observed. Electron microscopically, three kinds of keratohyalin-like granules were observed: (1) less electron-dense granules, the electron density of which was equivalent to that of the peripheral region of the nucleus; (2) normally electron-dense amorphous granules attached to the first type of granule, and (3) extremely less electron-dense granules with a finely granular appearance. The diameter of this finely granular material was around 21 nm and a fibrous structure was also observed in or attached to this granule.
Intralesional Chemotherapy for Kaposi’s Sarcoma
Authors: Brambilla L. , Boneschi V. , Beretta G. , Finzi A.F.
Published: October 2009

Over a period of 36 months we treated 12 patients with skin localizations of Kaposi’s sarcoma with intralesional chemotherapy. Local administration of vincristine (usual dose 0.1 mg per site) or bleomycin appeared to be very effective: in 93 injected nodules we obtained 74 complete and 19 partial regressions. No significant local or systemic toxicity has so far been observed.
Kaposi’s Sarcoma after Immunosuppressive Therapy for Bullous Pemphigoid
Authors: Scaparro E. , Borghi Susanna , Rebora A.
Published: October 2009

Immunosuppressed patients are at risk of acquiring Kaposi’s sarcoma. We describe a 86-year-old man who was receiving steroid therapy for bullous pemphigoid and rapidly developed Kaposi’s Sarcoma. The authors review and discuss the role of acquired immunosuppression in the pathogenesis of Kaposi’s sarcoma.
Bleomycin-Induced Raynaud’s Phenomenon and Acral Sclerosis
Authors: Snauwaert J. , Degreef H.
Published: October 2009

This study presents a case of two of the more uncommon side effects of bleomycin therapy for a metastasized testicular carcinoma: Raynaud’s phenomenon and acral sclerosis. It is suggested that this association indicates a common pathogenic mechanism. These side effects may serve as an experimental model in the study of Raynaud’s phenomenon and acral sclerosis.
Secretory IgA in Schönlein-Henoch Purpura
Authors: Kaneko Fumio , Mori Naotaka , Miura Yusho
Published: October 2009

2 young patients with Schönlein-Henoch purpura were investigated to detect secretory IgA and secretory component (SC) in skin lesions and urine in connection with the upper respiratory and intestinal symptoms at onset. In these cases, laboratory findings revealed relative leukocytosis, hematuria, and proteinuria in urinalysis, but no elevation of serum immunoglobulin levels and ASO titer. In biopsy specimens from purpuric lesions on lower extremities, leukocytoclastic vasculitis was found in the upper dermis histologically. Immunofluorescence showed deposits of IgG and IgA with SC and joining chain and complement at vessel walls in the upper dermis, and SC was deposited at the dermoepidermal junction. An attempt to concentrate urine from the patients revealed precipitin lines of IgG, IgA, and SC by using Ouchterlony’s method. These observations suggest that in patients with Schönlein-Henoch purpura circulating immune complexes containing secretory IgA and SC deposits in skin lesions and kidney exist in connection with the initial involvements on the mucous membranes of the respiratory and/or intestinal tracts.
Congenital Fistulas of the Lower Lip. Radiographic Evaluation
Authors: Ortega-Resinas M. , Sanchez-Conejo-Mir J. , Sanchez-Pedreño-Guillen P. , Camacho-Martinez F.
Published: October 2009

Congenital fistula of the lower lip was observed in 3 members of a family. There was no evidence of associated congenital malformations. In the father, we performed fistulography with radiopaque substance, showing that the fistular tract extended beyond the orbicularis oris muscle, a feature with no previous report in the literature.
Reduction of the In Vivo Virulence of Candida albicans by Pretreatment with Subinhibitory Azole Concentrations In Vitro
Authors: Plempel M. , Berg D.
Published: October 2009

Cells of Candida albicans exposed to subinhibitory concentrations of clotrimazole or bifonazole in shake cultures were found to have a reduced capacity to divide normally or produce germ tubes and mycelia under appropriate conditions, although treated cultures produced a cell mass equivalent to that of the untreated controls. The long-term morphological effects are considered to be due to azole-caused disturbances in ergosterol biosynthesis. When cells, pretreated with subinhibitory concentrations of the azole compounds, were injected intravenously in mice, the resultant infections were of reduced severity in comparison to controls, as measured by mortalities and colony forming units in kidneys.
Retention Time and Concentration in Human Skin of Bifonazole and Clotrimazole
Authors: Lücker P.W. , Beubler E. , Kukovetz W.R. , Ritter W.
Published: October 2009

The retention time and the extent of penetration in human skin of [14C] labelled bifonazole in comparison to [14C] labelled clotrimazole were investigated in 8 healthy volunteers. In the course of the investigation the backs of the volunteers were treated half with bifonazole, half with clotrimazole which remained on the skin for 24 h. From 24 to 168 h after the administration the skin was stripped with the tear-off strip technique. Three dermal layers of different depth were examined. The results of the examinations revealed, that the quantity of bifonazole that penetrated into the skin was more than twice as high as the quantity of clotrimazole. However, the half-lives and the mean retention times of bifonazole and clotrimazole were nearly similar to each other.
Bifonazole: Patch-Test Trials on Local Tolerance
Authors: Gip L.
Published: October 2009

Negative test reactions were obtained when 410 eczema patients (129 with allergic contact dermatitis) were tested using occlusion technique with bifonazole in yellow vaseline in the concentrations of 1 4,16 and 32%. The latter concentration is 32 times greater than the concentration used therapeutically. Thus bifonazole is not a primary irritant, when applied to the skin under occlusion, nor were any cross reactions observed with allergens previously known.
Comparative Clinical Trial of Bifonazole Solution versus Selenium Sulphide Shampoo in the Treatment of Pityriasis versicolor
Authors: Chu A.C.
Published: October 2009

38 patients were entered into a controlled randomised trial, comparing two forms of topical treatment for pityriasis versicolor. Diagnosis was made on clinical criteria and confirmed by direct microscopic examination of Parker Quink® / KOH preparations. 20 patients were treated with bifonazole solution daily for 2 weeks. 18 patients were treated with 2.5% selenium sulphide shampoo daily for one week and weekly for six weeks. Mycological examination showed that Malassezia furfur was present in all patients prior to treatment. At the end of the trial, 1 patient (5%) treated with bifonazole and 4 patients (22%) of those treated with selenium sulphide shampoo showed the presence of the fungus in the skin. This study demonstrates that bifonazole solution is an effective and well-tolerated form of treatment for pityriasis versicolor. A 2-week course of bifonazole solution was as effective as a 7-week course of selenium sulphide shampoo in eradicating the disease and had a lower relapse rate at 4 weeks.
Comparative Efficacy and Tolerance of 1% Bifonazole Cream and Bifonazole Cream Vehicle in Patients with Tinea versicolor
Authors: Mora R.G. , Greer D.L.
Published: October 2009

Bifonazole 1% cream (Mycospor®1) was compared to its cream vehicle in the treatment of tinea versicolor, using a once-a-day application for 2 weeks. Patients were evaluated both clinically and mycologically in order to assess the efficacy and tolerance of the medication. 29 patients were evaluated by statistical analysis. Bifonazole cream 1% was shown to be significantly more effective in the treatment of tinea versicolor when used nightly for 2 weeks than was the vehicle cream.
Bifonazole Cream: Once-a-Day Application every Second Day in Tinea cruris and Tinea corporis
Authors: Hernández-Pérez E.
Published: October 2009

The efficacy and local tolerance of Bay h 4502 1% cream were investigated in Tinea corporis and Tinea cruris. This biometrically designed, noncontrolled study was carried out in 32 patients (27 males and 5 females). The mean values of age, height and body weight were 25 years, 160.7 cm and 65.7 kg. Bay h 4502 1% cream was applied once daily every second day for 2 weeks. Mycological and clinical controls were carried out 1 week after starting therapy as well as 3 days and 2 weeks after the end of therapy. The direct microscopic examination was negative in 28/28 patients (100%) after the end of therapy as well as at the follow-up examination in 32/32 patients (100%). No pathogenic organisms were seen in 20/28 patients (71%) at the end of therapy and in 28/32 patients (88%) at the follow-up control. The overall success rate shows an analogous picture: ‘very good’ and ‘good’ was assessed for 26 patients (81%) at the end of therapy. In 50% of patients the onset of improvement occurred within 5 days after start of treatment, and between the 6th and 12th day in a further 47%. The local tolerance was good. The results obtained show that there is no difference by this study in comparison with previous studies with a treatment once daily every day. This gives additional safety by minimizing the risk of failures in all those patients sometimes not following strictly doctor’s advise.
Prophylaxis of Tinea pedis interdigitalis with Bifonazole, 1% Powder
Authors: Galimberti R.L. , Belli L. , Negroni R. , Castro J.M. , Rohwedder R. , Tuculet M.A.
Published: October 2009

With the objectives of determining the effectiveness of bifonazole 1% powder in the prophylactic treatment of tinea pedis interdigitalis and its local tolerance, 200 patients who achieved clinical and mycological cure in another previous trial with bifonazole 1% gel, and who were also reliable in the compliance of the treatment, were included in this study. Informed consent was requested and obtained in each case. This was a multicenter, double-blind, controlled and comparative study of one group (100 patients) treated with bifonazole verum against another group (100 patients) treated with bifonazole placebo. The allocation to each group was performed by randomization. Bifonazole was applied once daily in the morning on both feet, after showering, and inside shoes; patients applied it again when changing shoes or socks during the day. Treatment lasted up to 6 months. During the treatment, patients were clinically and mycologically assessed once a month and, if it was necessary, when signs and/or symptoms of infection reappeared. The evaluation criteria were based on the reinfection, clinically and mycologically demonstrable, during the treatment. 29 patients abandoned the treatment. Reinfection was observed in 57 out of the 171 patients who finished the treatment, 47 reinfections occurred in the placebo group and the remaining 10 in the verum group. Tolerance was excellent, no side effects were observed in any patient.
Treatment of Sebopsoriasis
Authors: Döring H.F.
Published: October 2009

1% Bifonazole cream and gel were used for the local therapy of sebopsoriasis and psoriasis in a pilot study with 20 patients. 3 of the 9 patients with psoriasis and 9 of the 11 patients with sebopsoriasis had improved markedly. The mechanisms of the effectiveness of this therapy will be discussed together with the results of some provocation tests with bacterial antigens.
Dermal Altemariasis in a Kidney Transplant Recipient
Authors: Bourlond A. , Alexandre G.
Published: October 2009

Dermal altemariasis represents one of the new infectious diseases related to immunodepression, especially in kidney recipients. Periodic acid-Schiffand Grocott stains of paraffin sections and mycological cultures must be resorted to in order to establish the diagnosis. Ketoconazole should be the best treatment.
Immunofluorescence in Cutaneous Leishmaniasis
Authors: Brenner S. , Srebrnik A. , Hazaz B. , Krakowski A.
Published: October 2009

A case of acute cutaneous leishmaniasis is reported in which skin biopsy of the lesion revealed deposits of IgM, fibrinogen and C3 in the blood vessel wall and granular deposits of IgG and C3 at the dermoepidermal junction. No immune complexes were detected in the healthy unaffected skin in the same patient and no circulating immune complexes were found in the blood. This case demonstrates tissue-bound immune complexes in cutaneous leishmaniasis.
A Comparison of Acyclovir Cream versus Placebo Cream versus Liquid Nitrogen in the Treatment of Viral Plantar Warts
Authors: Gibson J.R. , Harvey S.G. , Barth J. , Darley C.R. , Reshad H. , Burke C.A.
Published: October 2009

52 patients with a clinical diagnosis of verruca plantaris were entered into a randomised study of acyclovir cream versus placebo cream versus liquid nitrogen. 47 completed the initial 8-week assessment period. At first, liquid nitrogen was used as a positive control but after the entry of 33 patients it was discontinued as an initial therapy in order to obtain maximal numbers of patients on the cream treatments. At the end of the 8-week assessment period 5 of 18 (placebo cream), 7 of 18 (acyclovir cream) and 1 of 11 (liquid nitrogen) patients were completely cleared of their plantar warts. Patients who failed to clear on cream or liquid nitrogen treatments after the initial assessment period but who wished to continue therapy were subsequently treated with liquid nitrogen. Of a total of 27 patients treated vigorously with liquid nitrogen, for periods of time ranging from 2 to 34 weeks, only 11 were completely cleared of their warts at the end of the study. It is concluded that liquid nitrogen should not be considered as a routine treatment for plantar warts and that acyclovir cream is no better than placebo in the treatment of this condition.
Traitement de l’aphtose par la thalidomide et la colchicine
Authors: Genvo M.F. , Faure M. , Thivolet J.
Published: October 2009

Thalidomide alone (200–300 mg daily) or associated with colchicine (2–3 mg daily) was given orally to 25 patients with aphthosis: 8 patients with recurrent oral aphthae; 4 patients with recurrent mucocutaneous aphthosis, without visceral involvement, and 13 patients with Behçet’s disease (Touraine’s aphthosis). A major improvement was noted in all groups, with a rapid healing of mucous lesions and a rapid reduction of pain and burning as compared to prior spontaneous regressions. No new outbreaks were noted at a dose of 50–100 mg thalidomide and 1 mg colchicine daily. Under oral administration of the drugs, thrombophlebitis was noted in 1 case (third group) only. In the other patients with Behçet’s disease, skin aphthae, ocular symptoms, arthritis, superficial nodular phlebitis quickly disappeared with treatment. The efficiency of the drugs is only temporary, since new lesions usually appeared a few weeks after the end of treatment. Due to the relatively small number of cases studied in each group, no conclusions can be drawn concerning the efficiency of thalidomide alone compared to the association of the two drugs. However, this open trial does support the usefulness of thalidomide, or thalidomide and colchicine, in recurrent mucocutaneous aphthae, aphthosis and Behçet’s disease.
Ichthyosis hystrix
Authors: Ayala F. , Donofrio P.
Published: October 2009

An otherwise healthy 6-year-old girl, with lesions which clinically and histopathologically corresponded to the rare inherited disorder ichthyosis hystrix, is described. The classification of this disorder is briefly discussed.
Rodent Ulcer of the Palm
Authors: Starzycki Z. , Stachura J.
Published: October 2009

An ulcerous, infiltrating, mostly solid, partly cystic and keratotic type of basal cell carcinoma of the left palm, of about 5-years duration, in a 60-year-old woman is described. Light and electron microscopical findings are presented with some histogenetical considerations of the tumor.
Motretinide versus Benzoyl Peroxide in the Treatment of Acne vulgaris
Authors: Lassus A. , Juvakoski T. , Lauharanta J.
Published: October 2009

30 patients with acne vulgaris were treated topically with motretinide 0.1% vanishing cream or benzoyl peroxide 5% gel in an open study. Good results were obtained in both groups. Benzoyl peroxide caused local irritation in 73% of the patients, whereas motretinide was well tolerated except in 1 case. Motretinide is considered an alternative in the treatment of papulopustular acne in young adults.
Epidermodysplasia verruciformis in Lepromatous Leprosy
Authors: Jacyk W.K. , Lechner W.
Published: October 2009

2 African patients (sisters) suffering from lepromatous leprosy had epidermodysplasia verruciformis. Both patients had in addition recalcitrant superficial fungal infections and extensive relapsing scabies. The question is raised whether a generalized impairment of cell-mediated immunity, found in lepromatous leprosy, predisposes towards other particularly viral infections.
Plasmapheresis as an Alternative or Adjunctive Therapy in Problem Cases of Pemphigus
Authors: Ruocco V. , Astarita C. , Pisani M.
Published: October 2009

7 patients with pemphigus unresponsive to and/or with side effects from conventional therapy were treated by plasma exchange using three different procedures. Results were good and confirmed that plasmapheresis may actually be an alternative or adjunctive method of treating problem cases of pemphigus. The current drawbacks related to plasma exchange might be overcome in the future by dialysis of the patients’ own plasma through suitable immunoadsorbent matrixes.
Alopecia areata: A Clinical Study
Authors: De Weert J. , Temmerman L. , Kint A.
Published: October 2009

100 cases of alopecia areata are examined and the possible relationship with the presumed etiological factors (atopy, autoimmunity and psychosomatics) are looked for. When atopy or autoantibodies are present alopecia areata always runs a severe course. It is, however, impossible to establish a definite etiological relation between atopy or autoimmunity and alopecia areata.
Perforating Calcifying Epithelioma of Malherbe with a Rapid Evolution
Authors: Tsoïtis G. , Mandinaos C. , Kanitakis J.C.
Published: October 2009

A very rare case of calcifying epithelioma of Malherbe (CEM) with a rapid evolution and perforation of the epidermis is reported. Clinical appearance was atypical and did not suggest any diagnosis. Histopathologic examination shows a picture of CEM with some peculiar findings. Furthermore, in the upper dermis there are epithelial strands of shadow cells, partially calcified, tending to come in contact with the perforated epidermis and to be eliminated through it. The acute form of CEM and the mechanism of epidermal perforation in perforating dermatoses are discussed.
Purpura Provoked by Cold Exposure in a Skier
Authors: Nordlind K. , Bondesson L. , Johansson S.G. , Lagerholm B. , Lidén S. , Robèrt K.-H.
Published: October 2009

Case of a previously healthy young skier who developed purpura on his lower legs after cold exposure; the patient was not taking any medicine. No disease or disturbance except the physical trauma of cold could be found to explain his purpura.
A Simplified ELISA Method for Syphilis
Authors: Pospíšil Leopold
Published: October 2009

A new serological method for syphilis using a modified ELISA reaction is given. The reaction is performed on polystyrene carriers which have absorbed an ultrasonicated preparation of T. pallidum. The reaction between the antigen and antibody is detected by means of the addition of antihuman IgG swine globulin conjugated with horseradish peroxidase. To make the reaction visible, addition of 5-methyl-9-aminocarbazol in dimethylformamide is necessary. In a positive case of syphilis the carrier becomes a red-brown-violet color; in a negative reaction the white color does not change. The results obtained with this reaction are in absolute concordance with those of FTA-ABS and TPHA.