bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacto de los principios de estabilidad presupuestaria y sostenibilidad financiera en las competencias de las administraciones locales en materia de derechos sociales (2011-2019)
Authors: Silva Ardanuy Francisco Manuel
Published: July 2020

La entrada en vigor de la reforma del Art. 135 CE el 27 de Septiembre de 2011 en el marco de la aplicación de los principios de estabilidad presupuestaria y sostenibilidad financiera establecidos a nivel comunitario se tradujo en la aprobación de la Ley Orgánica 27/2012, de 27 de Abril de Estabilidad Presupuestaria y Sostenibilidad Financiera (LOEPSF) y la Ley 27/2013, de 27 de Diciembre, de Racionalización y Sostenibilidad  de la Administración Local (LRSAL) que vinieron a establecer medidas de disciplina fiscal y contención del déficit de carácter severo en el ámbito de las Administraciones Locales. Como consecuencia de su aplicación, las entidades locales perdieron 57.073 empleados en el periodo 2008-2018, vieron alterado su régimen de participación en los ingresos del Estado y de sus respectivas Comunidades Autónomas, al tiempo que su capacidad de materializar políticas públicas basadas en el despliegue de los derechos sociales en un contexto de recesión económica quedaron comprometidas. Conocer el impacto que la incorporación de los principios de estabilidad y sostenibilidad financiera al ordenamiento jurídico español ha tenido sobre la Administración local en el periodo 2011-2019 es el objeto del presente artículo.
Práxis antecipatória e escatológica do Reino de Deus: uma percepção a partir da Escatologia de Edward Schillebeeckx
Authors: Rocha Aldo Fernandes da
Published: July 2020

No presente artigo se encontram elementos percebidos por Edward Schillebecckx sobre a práxis do Reino de Deus como sua antecipação escatológica na vida de Jesus e na atuação de seus discípulos. O Reino de Deus é o eixo central em torno do qual se articulam a prédica e a prática de Jesus. Através de parábolas, milagres, gestos, atitudes e opções, sobretudo em sua morte e ressurreição, Jesus antecipa o Reino de Deus na história, embora seu acabamento glorioso se constitua a esperança da comunidade humana para o futuro escatológico, na parusia. A adesão de fé do discípulo ao Reino produz consequências e mudanças que se efetivam na promoção da vida em todas as esferas da experiência humana. Neste artigo, adotamos como método a pesquisa bibliográfica explicativa.
A teeth-discretized electromechanical model of a traveling-wave ultrasonic motor
Authors: Chen Ning , Fan Dapeng
Published: July 2020

Abstract. This paper develops an electromechanical TWUSM (traveling-wave ultrasonic motor) model combining the driving circuit with
the motor itself. An equivalent circuit model substituted for the
piezoelectric ceramics is designed in the driving circuit model to obtain accurate input currents and powers. Then teeth discretization is
implemented in the stator–rotor contact model, which can calculate the interaction forces more accurately. After building the complete model of
TWUSM, a typical startup–stopping process is divided into five stages by evaluating the changes in contact status and driving forces. Finally, the fitness of transient responses of the rotor speed increasing from 55 % to
89 % shows that the proposed model fits better than the one without teeth discretization, and the experimental tests under various driving parameters
verify the effectiveness of the model.
De la fonoteca al pódcast: análisis de los magacines 'estrella' de la radio generalista española en los repositorios abiertos
Authors: Rodríguez Luque Cristina , Alonso Fernández José Antonio , Legorburu José María
Published: July 2020

La digitalización está transformando la radio, al igual que al resto de medios de comunicación. Independientemente de las innovaciones que está introduciendo en las rutinas productivas o en la calidad de sonido, uno de los cambios más significativos radica en la posibilidad de escuchar a la carta cualquier contenido puesto en antena, rompiendo una dinámica de emisión en línea de casi un siglo. Esta modalidad de pódcast se ha convertido en una nueva vía de difusión para las cadenas generalistas españolas y, en especial, para sus contenidos de mayor audiencia, los magacines de la mañana del ciclo de programación semanal. El artículo aborda esta cuestión, mediante técnicas cualitativas y cuantitativas, con el fin de identificar las estrategias aplicadas en unas webs que, en apenas una década, se han ido convirtiendo en repositorios abiertos. Los resultados evidencian que los operadores consideran imprescindible esta forma de distribución para atender a una audiencia en transformación y para atraer a una nueva generación de oyentes que acceden al audio con su teléfono móvil. De este modo, se aprecian progresos significativos en el procesado de los contenidos, así como en el empleo de las redes sociales y las alertas para multiplicar su escucha.
Perspectiva histórica y visión de futuro de los archivos de la radio de servicio público en México
Authors: Rodríguez Reséndiz Perla Olivia
Published: July 2020

El artículo ofrece la revisión histórica y perspectiva de futuro de los archivos de la radio pública en México resultado de investigación cualitativa basada en estudios de caso y el análisis de documentación de emisoras de servicio público. Se establece la tipología de radio pública y se identifican algunos de los más destacados archivos de la radio de servicio público con el propósito de presentar importantes colecciones radiofónicas con valor documental. Además, se da cuenta de iniciativas de preservación que se han emprendido en emisoras de radio de servicio público. Con ello, se ofrece el panorama del estado de preservación de las colecciones radiofónicas de la radio de servicio público en México y la situación de vulnerabilidad de este patrimonio.
Introducción
Authors: Afuera Heredero Ángeles , Fernández-Sande Manuel
Published: July 2020

Cuando la radio española está próxima a su centenario –que celebraremos en 2024- los profesionales del medio y los investigadores lamentan, una vez más, no poder recuperar sus más antiguas emisiones y señalan las causas de no haber preservado tan valioso material sonoro – dificultades técnicas, ausencia de profesionales cualificados, falta de previsión por parte de las propias empresas del sector-. La paradoja aparece cuando detectamos que en pleno siglo XXI, con las dificultades técnicas superadas, los profesionales bien formados en las universidades y las empresas concienciadas de la importancia de sus fondos, no hay una preocupación por la preservación de los millones de contenidos digitales de audio que se están produciendo cada día. Los tradicionales problemas de preservación no han sido resueltos en el nuevo escenario digital; incluso se han agravado ante el incremento exponencial del ritmo de producción y la multiplicación de los sistemas de difusión.
The Basic Concepts Classification (BCC)
Authors: Szostak Rick
Published: July 2020

The Basics Concept Classification (BCC) is a “universal” scheme: it attempts to encompass all areas of human understanding. Whereas most universal schemes are organized around scholarly disciplines, the BCC is instead organized around phenomena (things), the relationships that exist among phenomena, and the properties that phenomena and relators may possess. This structure allows the BCC to apply facet analysis without requiring the use of “facet indicators.” The main motivation for the BCC was a recognition that existing classifications that are organized around disciplines serve interdisciplinary scholarship poorly. Complex concepts that might be understood quite differently across groups and individuals can generally be broken into basic concepts for which there is enough shared understanding for the purposes of classification. Documents, ideas, and objects are classified synthetically by combining entries from the schedules of phenomena, relators, and properties. The inclusion of separate schedules of-generally verb-like-relators is one of the most unusual aspects of the BCC. This (and the schedules of properties that serve as adjectives or adverbs) allows the production of sentence-like subject strings. Documents can then be classified in terms of the main arguments made in the document. BCC provides very precise descriptors of documents by combining phenomena, relators, and properties synthetically. The terminology employed in the BCC reduces terminological ambiguity. The BCC is still being developed and it needs to be fleshed out in certain respects. Yet it also needs to be applied; only in application can the feasibility and desirability of the classification be adequately assessed.
Typologizing regional urban settlement systems of Russia
Authors: Kirillov P. L. , A.G. Makhrova
Published: July 2020

The paper proposes typology of Russia regions by the key features of urban settlement networks. Applied typologizing method is designed for strategic spatial development and involves size-status parameters of central cities along with the intra-regional urban structure (the population of the regional centres and concentration of urban population at the intra-regional level) as principal criteria. At more specific level subtypes, these indicators are extended by two general characteristics of urban settlement – share of the urban population and urban network density. The approach formally allows to engage the settlement pattern morphology as a condition and factor that, directly or indirectly, differentiate regional development. By comparison of two main and two additional urban settlement parameters, 5 types (metropolitan urban systems (capital cities’ agglomerations), urban systems with 1+ million urban centers, systems with major urban centers, urban systems with large-city centers, undeveloped urban settlement systems) and 13 subtypes of regional urban settlement systems are set. The mostly wide-spread is the large-city type, covering a total of 35 regions. A brief description of the types and subtypes of regional urban settlement systems is provided, summarizing principal challenges and directions of strategic spatial development specified by regional features of urban settlement networks.
IMPACT OF PB, NI AND CD ON THE GERMINATION OF BARLEY SEEDS, VARIETY JADRAN
Authors: Vasić Predrag , Jakšić Tatjana , Đelić Gorica
Published: July 2020

The aim of this study was to determine the effect of lead, nickel and cadmium on the germination of barley seeds (Hordeum vulgare L.) of Jadran variety. Based on the percentage of germination, germination energy, and root and hypocotyl length, authors done an analysis of the effects of PbCl2, NiCl2, CdCl2 solutions, in concentrations of 103 mol/m3, 102 mol/m3, 10 mol/m3, 1 mol/m3, 10 -1 mol/m3, 10-2 mol/m3. The results showed that germination and germgrowthin stress conditions which are caused by heavy metals depend on the type of metal and its concentrations. The most toxic effect of alltested solutions had CdCl2, and the weakest toxic effect had PbCl2.
NCCN Task Force Report: Bone Health and Cancer Care
Authors: Theriault Richard L. , Biermann J. Sybil , Brown Elizabeth , Brufsky Adam , Demers Laurence , Grewal Ravinder K. , Guise Theresa , Jackson Rebecca , McEnery Kevin , Podoloff Donald , Ravdin Peter , Shapiro Charles L. , Smith Matthew , Van Poznak Catherine H.
Published: July 2020

Higher incidences of osteoporosis and osteopenia are found in cancer patients, particularly in women receiving aromatase inhibitors or with chemotherapy-induced ovarian failure, or in men with prostate cancer and androgen deprivation therapy. Therefore, management of long-term bone health is emerging as an important aspect of comprehensive cancer care. Patients with cancer typically have a number of additional risk factors for osteoporosis that should prompt screening, regardless of patient age or sex. Maintaining bone health requires a broad knowledge base, including understanding underlying bone metabolism and how it is affected by both cancer itself and the drugs used to treat cancer, the effect of chemotherapy-induced menopause on bone health, bone markers and imaging techniques used to assess bone health, therapeutic strategies to maintain bone health, and treatment of bone metastases, including surgery for pathologic fractures. Multiple members of the healthcare team may need to be involved in education and care of the patient. This report summarizes discussion of these and other issues regarding bone health and cancer care from the NCCN Bone Health and Cancer Care Task Force meeting in early 2006. (JNCCN 2006;4(Suppl 2):S1-S24)
Beijing bag kulisserne
Authors: Anderlini Jamil
Published: July 2020

Jamil Anderlini om Neil Percival Heywood,
Syrere tester EU’s solidaritet
Authors: Selsøe Sørensen Martin
Published: July 2020

Martin Selsøe Sørensen skriver om hvordan flytningekrisen fra Syrien kan flække det Europæriske samarbejde.
Psychology, Performance, and Social Context of Laughter in Azerbaijan Folklore
Authors: Garayev Safa
Published: July 2020

Social context often drives the performance of laughter in cultural situations. As a metaphor, laughter provides not only an exchange of integrative information among the community members, but also the enactment of aggressive relations in the society. These characteristics may be seen clearly while observing metaphors related to the performance of laughter in the Azerbaijani socio-cultural environment. In the study of humor, content is usually analyzed but the performance of behavioral cues such as laughter is neglected, although it can shed light on the meaning of the communication. To understand folk behaviors and texts related to the laughter, I argue that special attention needs to be given to behaviors as well as texts communicated in a social situation. This study reveals that the jokes causing laughter are accepted and perceived by the male and female audiences differently. Women's laughter receives disapproval in the Azerbaijan cultural context regarding sexuality. Men take such laughter to be a threat to their manliness.
Exploring the connection between indigenous peoples’ human rights and international environmental law
Authors: Delgado Galárraga Mario Alejandro
Published: July 2020

The paper reviews whether Indigenous Peoples’ worldview has di-rectly influenced or not the decisions made by the Inter-American Court of Human Rights related exclusively to their human and environmental rights.In the first section of the investigation, it is described the main aspects to take into consideration regarding Indigenous Peoples and international law; i.e. conceptualization of the term Indigenous Peoples, its evolution in interna-tional law, and their core rights. Then, the text will deal with the relationship between Human Rights Law and International Environmental Law, through the discussion of how human rights have been included in the context of inter-national environmental law. Afterwards, the study will explore the close bond that exists between indigenous peoples and the environment, by relating to the different conceptions of its features according to them. Finally, the paper will analyse the decisions taken by the Inter-American Court of Human Rights in cases related to indigenous peoples’ environmental issues. The conclusion will lead to determine the contribution of human rights and international environ-mental law to solve indigenous peoples’controversies and vice versa
The value of summary statistics for anomaly detection in temporally evolving networks: A performance evaluation study
Authors: Kodali Lata , Sengupta Srijan , House Leanna , Woodall William H.
Published: July 2020

Analysis of network data has emerged as an active research area in statistics. Much of the focus of ongoing research has been on static networks that represent a single snapshot or aggregated historical data unchanging over time. However, most networks result from temporally evolving systems that exhibit intrinsic dynamic behavior. Monitoring such temporally varying networks to detect anomalous changes has applications in both social and physical sciences. In this work, we perform an evaluation study of the use of summary statistics for anomaly detection in temporally evolving networks by incorporating principles from statistical process monitoring. In contrast to previous studies, we deliberately incorporate temporal autocorrelation in our study. Other considerations in our comprehensive assessment include types and duration of anomaly, model type, and sparsity in temporally evolving networks. We conclude that the use of summary statistics can be valuable tools for network monitoring and often perform better than more complicated statistics.
Embryo, larval, and juvenile staging of Lytechinus pictus from fertilization through sexual maturation
Authors: Nesbit Katherine T. , Hamdoun Amro
Published: July 2020

Background

Sea urchin embryos have been used for more than a century in the study of fertilization and early development. However, several of the species used, such as Strongylocentrotus purpuratus, have long generation times making them suboptimal for transgenerational studies.

Results

Here, we present an overview of the development of a rapidly developing echinoderm species, Lytechinus pictus, from fertilization through sexual maturation. When grown at room temperature (20°C) embryos complete the first cell cycle in 90 minutes, followed by subsequent cleavages every 45 minutes, leading to hatching at 9 hours postfertilization (hpf). The swimming embryos gastrulate from 12 to 36 hpf and produce the cells which subsequently give rise to the larval skeleton and immunocytes. Larvae begin to feed at 2 days and metamorphose by 3 weeks. Juveniles reach sexual maturity at 4 to 6 months of age, depending on individual growth rate.

Conclusions

This staging scheme lays a foundation for future studies in L. pictus, which share many of the attractive features of other urchins but have the key advantage of rapid development to sexual maturation. This is significant for multigenerational and genetic studies newly enabled by CRISPR‐CAS mediated gene editing.
Inhibiting microRNA‐301b suppresses cell growth and targets RNF38 in cervical carcinoma
Authors: Guo Wen‐Ling , Li Ning , Ma Jian‐Lin , Chen Xue‐Mei , Shi Fan‐Ying
Published: July 2020

It has been reported microRNA‐301b (miR‐301b) was involved in the tumorigenesis of some cancers, but it has not been investigated in cervical carcinoma yet. In this study, miR‐301b was found significantly upregulated in cervical carcinoma, and patients with high miR‐301b expression had a shorter overall survival. When miR‐301b was knocked down in cervical carcinoma cells, the cell growth could be significantly abolished. Our further studies showed miR‐301b targeted RNF38, and inhibited its expression in cervical carcinoma cells. Moreover, RNF38 was found downregulated in cervical carcinoma, and miR‐301b expression in cervical tissues was found negatively correlated with RNF38 expression. In addition, overexpression of RNF38 significantly inhibited cervical carcinoma cell growth, but overexpression of miR‐301b suppressed RNF38‐induced cell growth inhibition in cervical carcinoma. Collectively, this study suggested miR‐301b could be a novel target for cervical carcinoma treatment.
A coupled system of Langevin differential equations of fractional order and associated to antiperiodic boundary conditions
Authors: Baghani Hamid , Alzabut Jehad , Nieto Juan J.
Published: July 2020

In this paper, we provide an extension result for the existence and uniqueness of solutions for a coupled system of fractional Langevin differential equations with antiperiodic boundary conditions. The system involves two different Caputo fractional derivatives defined on different intervals and associated with boundary conditions described by sequential fractional derivatives. As a conclusion for our main result, we deduce the results of H. Fazli, J.J. Nieto, Fractional Langevin equation with anti‐periodic boundary conditions, Chaos Soliton Fract, 114 (2018),332–337 under less restrictive conditions. The consistency of the main results is demonstrated by two numerical examples. For the sake of completeness, we end the paper by a concluding discussion.
Photovoltaic lifetime forecast model based on degradation patterns
Authors: Kaaya Ismail , Lindig Sascha , Weiss Karl‐Anders , Virtuani Alessandro , Sidrach de Cardona Ortin Mariano , Moser David
Published: July 2020

The ever‐growing secondary market of photovoltaic (PV) systems (i.e., the transaction of solar plants ownership) calls for reliable and high‐quality long‐term PV degradation forecasts to mitigate the financial risks. However, when long‐term PV performance degradation forecasts are required after a short time with limited degradation history, the existing physical and data‐driven methods often provide unrealistic degradation scenarios. Therefore, we present a new data‐driven method to forecast PV lifetime after a small performance degradation of only 3%. To achieve an accurate and reliable forecast, the developed method addresses the fundamental challenges that usually affect long‐term degradation evaluation such as data treatment, choosing a good degradation model, and understanding the different degradation patterns. In the paper, we propose and describe an algorithm for degradation trend evaluation, a new concept of multiple “time‐ and degradation pattern‐dependent” degradation factors. The proposed method has been calibrated and validated using different PV modules and systems data of 5 to 35 years of field exposure. The model has been benchmarked against existing statistical models evaluating 11 experimental PV systems with different technologies. The key advantage of our model over statistical ones is the ability to perform more reliable forecasts with limited degradation history. With an average relative uncertainty of 7.0%, our model is outstanding in consistency for different forecasting time horizons. Moreover, the model is applicable to all PV technologies. The proposed method will aid in making reliable financial decisions and also in adequately planning operation and maintenance activities.
Persistence targeted smoking cessation for smokers with schizophrenia or schizoaffective disorder: a feasibility study
Authors: Steinberg Marc L. , Billingsley Benjamin , Rosen Rachel , Epstein Elizabeth E. , Lu Shou-En , Weickert Nicole , Williams Jill M.
Published: July 2020

Introduction

Individuals with schizophrenia are more likely to smoke and less likely to quit smoking than those without schizophrenia. Because task persistence is lower in smokers with than without schizophrenia, it is possible that lower levels of task persistence may contribute to greater difficulties in quitting smoking observed among smokers with schizophrenia.

Aims

To develop a feasible and acceptable intervention for smokers with schizophrenia.

Methods

Participants (N = 24) attended eight weekly individual cognitive behavioral therapy sessions for tobacco use disorder with a focus on increasing task persistence and received 10 weeks of nicotine patch.

Results

In total, 93.8% of participants rated the intervention as at least a 6 out of 7 regarding how ‘easy to understand’ it was and 81.3% rated the treatment as at least a 6 out of 7 regarding how helpful it was to them. A total of 62.5% attended at least six of the eight sessions and session attendance was positively related to nicotine dependence and age and negatively related to self-efficacy for quitting.

Discussion

This intervention was feasible and acceptable to smokers with schizophrenia. Future research will examine questions appropriate for later stages of therapy development such as initial efficacy of the intervention and task persistence as a mediator of treatment outcome.
Gen Z, Gender, and COVID-19
Authors: Deckman Melissa , McDonald Jared , Rouse Stella , Kromer Mileah
Published: July 2020

Using a national survey of Generation Z conducted in late May 2020, we measure attitudes about the impact of the coronavirus on personal health, financial and job concerns, views about shelter-in-place laws, and 2020 voting intentions. Gen Z women express greater health and economic concerns and support for shelter-in-place measures than their male counterparts, but this gender gap is largely mitigated by party and other covariates. Party also mediates the differences between young male and female voters concerning the influence of the coronavirus on their vote choice in 2020. Notably, women have significantly greater concern about the impact of COVID-19 on their personal financial situation, while Gen Z men express more concern about their personal health amid COVID-19 in more fully specified statistical models. This research contributes to the growing literature that examines not only the sorting effect of party on the gender gap but also how different identities—in this case, generation—can help explain the persistent political divides between men and women.
Further Validation and Cross-Cultural Replication of the Video Game	Demand Scale
Authors: Koban Kevin , Bowman Nicholas D.
Published: July 2020

Abstract. The Video Game Demand Scale (VGDS) is a 26-item, five-factor scale designed to assess the cognitive, emotional, physical, and social demands experienced by video game players. Given the international relevance of video games, cross-cultural research focusing on gamers beyond the US community holds promise to substantiate and refine extant approaches. The current study introduces a German-language VGDS, which was tested for measurement invariance with respect to the original US scale as well as predictive, convergent, and concurrent validity (replicating the original VGDS validity tests). Results revealed configural and partial metric measurement invariance when compared with data from the original scale. Validity tests between the German-language VGDS and common measures of task load, entertainment, need satisfaction, and game ratings largely replicated original results. Overall, we conclude that the VGDS is a reliable, valid, and useful contribution to media psychological game research and suggest areas of future work for which an interactivity-as-demand focus might benefit.
Bootstrap Aggregation and Cross‐Validation Methods to Reduce Overfitting in Reservoir Control Policy Search
Authors: Brodeur Zachary P. , Herman Jonathan D. , Steinschneider Scott
Published: July 2020

Policy search methods provide a heuristic mapping between observations and decisions and have been widely used in reservoir control studies. However, recent studies have observed a tendency for policy search methods to overfit to the hydrologic data used in training, particularly the sequence of flood and drought events. This technical note develops an extension of bootstrap aggregation (bagging) and cross‐validation techniques, inspired by the machine learning literature, to improve reservoir control policy performance on out‐of‐sample hydrological sequences. We explore these methods using a case study of Folsom Reservoir, California, using control policies structured as binary trees, and streamflow resampling based on the paleo‐inflow record. Results show that calibration‐validation strategies for policy selection coupled with certain ensemble aggregation methods can improve out‐of‐sample performance in water supply and flood risk objectives over baseline performance given fixed computational costs. Our findings highlight the potential to improve policy search methodologies by leveraging these well‐established model training strategies from machine learning.
Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway
Authors: Wang Yifan , Liao Ruocen , Chen Xingyu , Ying Xuhua , Chen Guanping , Li Mingqian , Dong Chenfang
Published: July 2020

Breast cancer is considered to be the most prevalent cancer in women worldwide, and metastasis is the primary cause of death. Protease-activated receptor 1 (PAR1) is a GPCR family member involved in the invasive and metastatic processes of cancer cells. However, the functions and underlying mechanisms of PAR1 in breast cancer remain unclear. In this study, we found that PAR1 is highly expressed in high invasive breast cancer cells, and predicts poor prognosis in ER-negative and high-grade breast cancer patients. Mechanistically, Twist transcriptionally induces PAR1 expression, leading to inhibition of Hippo pathway and activation of YAP/TAZ; Inhibition of PAR1 suppresses YAP/TAZ-induced epithelial-mesenchymal transition (EMT), invasion, migration, cancer stem cell (CSC)-like properties, tumor growth and metastasis of breast cancer cells in vitro and in vivo. These findings suggest that PAR1 acts as a direct transcriptionally target of Twist, can promote EMT, tumorigenicity and metastasis by controlling the Hippo pathway; this may lead to a potential therapeutic target for treating invasive breast cancer.
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells
Authors: Du Shihao , Song Xiaoyu , Li Yuan , Cao Yalei , Chu Fuhao , Durojaye Olanrewaju Ayodeji , Su Zeqi , Shi Xiaoguang , Wang Jing , Cheng Juan , Wang Tangshun , Gao Xiang , Chen Yan , Zeng Wuzhekai , Wang Fengsong , Wang DongMei , Liu Xing , Ding Xia
Published: July 2020

Progression of hepatocellular carcinoma involves multiple genetic and epigenetic alterations that promote cancer invasion and metastasis. Our recent study revealed that hyperphosphorylation of ezrin promotes intrahepatic metastasis in vivo and cell migration in vitro. Celastrol is a natural product from traditional Chinese medicine which has been used in treating liver cancer. However, the mechanism of action underlying celastrol treatment was less clear. Here we show that ROCK2 is a novel target of celastrol and inhibition of ROCK2 suppresses elicited ezrin activation and liver cancer cell migration. Using cell monolayer wound healing, we carried out a phenotype-based screen of natural products and discovered the efficacy of celastrol in inhibiting cell migration. The molecular target of celastrol was identified as ROCK2 using celastrol affinity pull-down assay. Our molecular docking analyses indicated celastrol binds to the active site of ROCK2 kinase. Mechanistically, celastrol inhibits the ROCK2-mediated phosphorylation of ezrin at Thr567 which harnesses liver cancer cell migration. Our findings suggest that targeting ROCK2-ezrin signaling is a potential therapeutic niche for celastrol-based intervention of cancer progression in hepatocellular carcinoma.
Mathematical Simulation of the Synchronized Asynchronous Electric Drive
Authors: Meshcheryakov Victor , Sibirtsev Dmitry , Mikhailova Ekaterina
Published: July 2020

At the end of the last century asynchronous motors with a phase rotor were most widely used among adjustable-speed AC drives. They were used for conveyors, transporters, cranes. That was due to the relative simplicity to adjust the motor speed by acting on the rotor chain. The introduction of a frequency control method in such drives is now complicated by the fact that most frequency converters are designed to be used in drives with a cage asynchronous motor. Shorting of a phase winding leads to highly increased losses during acceleration and motor speed control. If the stator winding of a wound-rotor asynchronous motor is connected to a frequency converter and the rotor winding is connected to a DC link of this converter, the motor will have properties of a synchronous one. The electric drive is able to work in a wide range, while motor characteristics are absolutely rigid. The implementation of such control method is presented in this article. The control system operation has been tested with simulation in the Matlab Simulink software pack. The obtained results are defined as follows.
The optimal gas dynamic design system of industrial centrifugal compressors based on Universal modeling method
Authors: Galerkin Yuri , Rekstin Aleksey , Drozdov Aleksandr , Soldatova Kristina , Solovyeva Olga , Popova Elena
Published: July 2020

We present the modern stage of development of Universal Modeling Method, a complex of mathematical models and software for optimal design of centrifugal compressors - a new version of simplified mathematical model of efficiency and new software for variation calculations of multistage compressors. Based on this numerical calculation complex we have created a method for preliminary design of flow paths of stages - 2D and 3D impellers, vane and vaneless diffusers and return channels. The new, 9th version of its mathematical model features a quasi-3D calculation method of 2D and 3D impellers design, a new principle of pressure characteristic calculation, a new model of vaneless diffusers and much more. “Digital twin of a centrifugal compressor stage” and “3D compressor” software create digital descriptions of the flow part and its solid model (“digital twin”).
Modeling of application the FACTS devices on the example of power system of United Power System of Center
Authors: Udaratin Alexey , Loginov Kirill , Akhmetov Timur , Nemirovskiy Alexandr
Published: July 2020

This paper considers installation of a flexible AC transmission system (FACTS) device on the 500 kV line of substation (SS) Belozerskaya - SS Vologodskaya of the United Power System of Center. Three FACTS devices in normal operation mode were modeled: a static reactive power compensator (STATCOM), a static synchronous series compensator, and a unified power flow control system. The obtained results are summarized in Table, which substantiates the choice of the best compensation for the Belozerskaya Vologodskaya line.
Experimental and numerical study of non-stationary solid-liquid phase transitions of n-tetradecane
Authors: Zakharova Viktoria , Kuznetsov Pavel , Kalimzhanov Daniyar , Baranenko Aleksandr
Published: July 2020

During the experiments, four spherical flasks with n-tetradecane with a total mass of 0.344 kg were placed in a test container inside which an aqueous solution of propylene glycol with a mass concentration of 50% and an initial temperature of 25 °C was circulating. As a result of studies, the values of heat flows at different time intervals during the solid-liquid phase transition of n-tetradecane were obtained. Based on the modeling of the processes, the distribution of temperature and velocity of the heat carrier in the test container as well as the values of the local heat transfer coefficients on the surface of the flasks were established. Numerical calculations of the process of phase transition being studied according to the authors’ model were also performed. Numerical calculations of the process under study have been performed using the authors’ model. A satisfactory convergence of the experimental and calculated values of the heat flow has been obtained. The results can be used in the development of thermal energy accumulators with n-tetradecane.
A method for construction of an energy-efficient ice floating pier in the Arctic using hardened ice
Authors: Kagan G L , Mukhametova L. R. , Velsovskij A. Y.
Published: July 2020

This paper presents studies on increasing the ice strength using various additives. It is indicated that addition of wood fiber (artificial composition) and vegetable fiber (natural composition - frozen peat) to ice is an energy-efficient method to increase its strength. This enhances the possibilities of using ice during building and construction works in the Arctic. As an example, the authors proposed a floating ice pier design.
Begründung für die neuen LDL-Cholesterin-Zielwerte
Authors: Otto Sylvia , Schulze P. Christian , Weingärtner Oliver
Published: July 2020

Die aktualisierte Dyslipidämie-Leitlinie von 2019 definiert noch tiefere Therapieziele in Abhängigkeit der individuellen Risikokategorie, sowohl für die Primär- als auch für die Sekundärprävention. LDL-Cholesterin bleibt das primäre Maß zur Risikoabschätzung und Haupt-Therapieziel. Daneben sollte Lp(a) einmal im Erwachsenenalter zur Identifikation von Risikopersonen bestimmt werden. Die letzten großen randomisierten Studien zu Ezetimib und PCSK9-Inhibitoren konnten eine weitere relative Risikoreduktion für kardiovaskuläre Ereignisse nachweisen. Dabei ist die Verringerung des kardiovaskulären Risikos proportional zur absoluten LDL-C-Senkung. Für Patienten mit sehr hohem Risiko ist das neue LDL-C-Ziel < 1,4 mmol/l (55 mg/dl) bzw. eine zusätzliche prozentuale Reduktion des LDL-C-Ausgangswerts um ≥ 50%. Eine ausreichende zelluläre Cholesterinversorgung besteht bei LDL-Spiegeln von nur 25 mg/dl (0,65 mmol/l), wie sie zur Geburt vorliegen.
Interfacial Fracture Toughness Comparison of Three Indirect Resin Composites to Dentin and Polyether Ether Ketone Polymer
Authors: Khalesi Rayhaneh , Abbasi Mahdi , Shahidi Zahra , Tabatabaei Masoumeh Hasani , Moradi Zohreh
Published: July 2020

Objectives Advances in laboratory composites and their high wear resistance and fracture toughness have resulted in their growing popularity and increasing use for dental restorations. This study sought to assess the fracture toughness of three indirect composites bonded to dental substrate and polyether ether ketone (PEEK) polymer.

Materials and Methods This in vitro study was conducted on two groups of dental and polymer substrates. Each substrate was bonded to three indirect composite resins. Sixty blocks (3 × 3 × 12 mm) were made of sound bovine anterior teeth and PEEK polymer. Sixty blocks (3 × 3 × 12 mm) were fabricated of CRIOS (Coltene, Germany), high impact polymer composite (HIPC; Bredent, Germany), and GRADIA (Indirect; GC, Japan) composite resins. Composites were bonded to dentin using Panavia F 2.0 (Kuraray, Japan). For bonding to PEEK, Combo.lign (Bredent) and Visio.Link (Bredent) luting cements were used. In all samples, a single-edge notch was created by a no. 11 surgical blade at the interface. The samples were subjected to 3,500 thermal cycles, and their fracture toughness was measured in a universal testing machine (Zwick/Roell, Germany) by application of four-point flexural load.

Statistical Analysis Data were analyzed using one-way analysis of variance, Kruskal–Wallis.

Results The fracture toughness of CRIOS–PEEK interface was significantly higher than HIPC–PEEK. The fracture toughness of GRADIA–PEEK was not significantly different from that of HIPC and CRIOS. The fracture toughness of GRADIA–dentin was significantly higher than HIPC–dentin.

Conclusion Considering the limitations of this study, GRADIA has the highest bond strength to dentin, while CRIOS shows the highest bond strength to PEEK.
Mental Health for Men Who Have Sex with Men (MSM) and Women Who Have Sex with Women (WSW)
Authors: Salomaa Anna C. , Matsick Jes L.
Published: July 2020

This chapter reviews mental health research of sexual minorities who are defined by their same-gender sexual behavior. Women who have sex with women (WSW) and men who have sex with men (MSM) encompass not only those who identify as LGBQ+ but also people who identify as heterosexual or are unsure of their sexual orientation. The authors discuss the implications of this broad categorization on the study of mental disorders and psychological distress and present the typical rates of risk for WSW and MSM overall and within subgroups (e.g., heterosexual-identified WSW, Black MSM). This area of research is often hindered by the multiple ways in which MSM and WSW groups can be defined and the vast heterogeneity of people who fall within these categories. Further, because of the origins of WSW/MSM-terminology in HIV/AIDS research, there is a gendered imbalance in allocation of research funding toward MSM over WSW. Future research should address the limitations of this categorization system in understanding mental health by including multiple measures of sexuality to create a fine-grained understanding of which experiences of WSW/MSM transfer risk and by addressing the paucity of research on WSW and their mental health.
Effect of Pain Management Electronic Order Sets on Opioid Use in Adult Rib Fracture Patients
Authors: Hughes Andrea M. , Baumhover Lisa A. , Fuchsen Elizabeth A. , Spilman Sarah K.
Published: July 2020

Background:

Inpatient pain management order sets are an important and necessary tool for standardizing and enhancing pain management for patients with traumatic injury. The purpose of this study was to assess the impact of revised inpatient pain management electronic order sets on opioid usage for patients with significant chest wall trauma.

Methods:

A retrospective pre-post study was conducted for adult patients with 3 or more rib fractures admitted to the hospital at a Level 1 trauma center. Two periods were compared: 1 year prior to the order set changes and the period immediately after the revisions were implemented. Differences between medians were assessed using Kruskal–Wallis test by ranks, and differences between nominal variables were assessed with χ2 test.

Results:

Twenty-five patients were analyzed for each period. There was no significant change between periods in the total amount of opioid received per day. There was a significant reduction in intravenous (IV) opioid use on the general inpatient floor (61% vs. 24%, p = .01), as well as in the percentage of patients who received IV opioid within 24 hr of discharge (40% vs. 4%, p = .002).

Conclusion:

Revised inpatient pain management order sets did not reduce overall opioid usage in a population of patients with 3 or more rib fractures. However, significant improvements were noted in decreased IV opioid usage on the general inpatient floors and within 24 hr of patient discharge from the hospital.
Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis
Authors: Xu Haitao , Qu Yiming
Published: July 2020

Background:

The present study was performed to statistically explore the effect of anthrax toxin receptor 2 (ANTXR2) polymorphism rs4333130 on individual susceptibility to ankylosing spondylitis (AS) using the method of meta-analysis.

Methods:

All of the eligible reports were retrieved from well-known electronic databases. The strength of the association between ANTXR2 polymorphism rs4333130 and the susceptibility to AS was evaluated using pooled odds ratios (ORs) with 95% confidence intervals (95% CIs). In addition, subgroup analysis was also performed on the basis of ethnicity to further explore specific correlation between our studied polymorphism and the disease risk. Inter-study heterogeneity was detected with Q test, and P < .05 was considered statistically significant. Sensitivity analysis was implemented through removing each of eligible studies and then recalculating overall effects to test the reliability of final estimates. Publication bias among included studies was inspected with both Begg funnel plot and Egger regression test.

Results:

A total of 6 eligible papers were finally incorporated into the present meta-analysis. In total analysis, ANTXR2 polymorphism rs4333130 was significantly related to decreased risk of AS under CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T and TC versus TT contrasts (OR = 0.35, 95% CI = 0.20–0.64; OR = 0.81, 95% CI = 0.69–0.95; OR = 0.38, 95% CI = 0.21–0.68; OR = 0.89, 95% CI = 0.84–0.95; OR = 0.84, 95% CI = 0.72–0.99). Moreover, a similar effect was also observed in Asian and Caucasian subgroups under corresponding genetic models after stratification analysis based on ethnicity.

Conclusion:

ANTXR2 polymorphism rs4333130 may function as a protective factor against AS incidence.
The inferior parathyroid glands preserved in site recover faster than the superior parathyroid glands preserved in site after thyroid surgery for carcinoma
Authors: Wang Bin , Zhu Chun-Rong , Liu Hong , Yao Xin-Min , Wu Jian
Published: July 2020

Due to the great difficulty in being preserved in site for the variable positions, the inferior parathyroid glands were advised to being routinely autotransplanted to prevent permanent hypoparathyroidism. The aim of this study was to compare the performance in the function of the superior parathyroid glands preserved in site with that of the inferior parathyroid glands preserved in site.

We conducted a retrospective study including patients who underwent thyroid surgery for papillary thyroid carcinoma at our department between January 2014 and June 2018. According to the number and original position of the autoplastic parathyroid gland(s), patients were divided into group 1 (1 superior parathyroid gland), group 2 (1 inferior parathyroid glands), group 3 (1 superior parathyroid gland and 1 inferior parathyroid gland) and group 4 (2 inferior parathyroid glands). The postoperative complications and serum parathyroid hormone and calcium were analyzed.

A total of 368 patients were included in the study, among them 27, 243, 40, and 58 patients were divided into group 1, group 2, group 3, and group 4, respectively. Compared with those in group 2, the serum parathyroid hormones were higher at 1 week (2.98 ± 1.52 vs 2.42 ± 0.89, P = .049) and 2 weeks (3.49 ± 1.42 vs 2.8 ± 0.81, P = .019) postoperatively in group 1. There was also significantly different in the serum parathyroid hormone at 2 weeks postoperatively between group 3 and group 4 (2.95 ± 0.98 vs 2.58 ± 0.82, P = .047).

The inferior parathyroid glands preserved in site recover faster than the superior parathyroid glands preserved in site.
Effectiveness and safety of indirect moxibustion for the treatment of allergic rhinitis
Authors: Yuan Ting , Fu Yong , Xiong Jun , Zhang Haifeng , Yang Jun , Wang Xue , Fan Hao , Jiang Yunfeng , Zhou Xiaohong , Liao Kai , Xu Lingling
Published: July 2020

Background:

Allergic rhinitis (AR) is a common allergic disorder worldwide. Western medicine is not optimistic about the therapeutic effect of this disease. However, moxibustion can enhance vital energy or immunity through a great number of clinical trials. Thus, the aim of this systematic review and meta-analysis is to systematically evaluate the effectiveness and safety of indirect moxibustion for treating AR.

Methods:

We will conduct a comprehensive literature search in Medline, PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure Database, WanFang Database, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database from inception to August 2020 without any language restriction. In addition, we will retrieve the unpublished studies and the references of initially included literature manually. Reviewers will identify studies, extract data, and assess the quality independently. The outcomes of interest include: total effective rate, total nasal symptom score, total non-nasal symptom score, rhinitis quality of life questionnaire, visual analog scale, laboratory indicators (i.e., serum levels of IgE, IgA, or IgG), and adverse events. Randomized clinical trials will be collected, methodological quality will be evaluated using the Cochrane risk-of-bias assessment tool, and the level of evidence will be rated using the Grading of Recommendations, Assessment, Development and Evaluation approach. Meta-analysis will be performed using RevMan 5.3.0 software. The heterogeneity test will be conducted between the studies, and P < .1 and I2 > 50% are the thresholds for the tests. We will utilize the fixed effects model or the random effects model according to the size of heterogeneity.

Results:

Because the review is ongoing, no results can be reported.

Conclusions:

The results of this review will provide reliable evidence for effectiveness and safety of indirect moxibustion for treating AR.

Ethics and dissemination:

Ethical approval is not required for this study. This systematic review and meta-analysis will be disseminated online and on paper to help guide clinicians.

PROSPERO Registration number:

CRD42019140944.