bluuebunny/crossref_metadata_2025 huggingface dataset:
Reductive etherification of furfural via hydrogenolysis with Pd-modified aluminum phosphate and formic acid
Authors: Fang Wenting , Egebo Jonas , Schill Leonhard , Chen Hua , Riisager Anders
Published: September 2022

Furanic ether biofuels form in high yield from furfural by a novel, simple, and efficient catalytic approach using Pd nanoparticles supported on aluminum phosphate with formic acid as a hydrogen donor.
A potent candidate against Zika virus infection: Synthesis, bioactivity, radiolabeling and biodistribution studies
Authors: Kumar Sumit , Sharma Neha , Dantas Willyenne Marilia , do Nascimento Jessica Catarine Frutuoso , Maus Hannah , de Oliveira Ronaldo Nascimento , Pandit Unnat , Singh Agam P. , Schirmeister Tanja , Hazari Puja Panwar , Pena Lindomar , Poonam  , Rathi Brijesh
Published: September 2022

Compound VI exhibits potent activity against Zika virus infection combined with favorable cellular uptake and biodistribution without apparent cytotoxicity in a mouse model.
Development of a gold-based lateral flow immunoassay for the determination of abscisic acid
Authors: Yan Jieyu , Xu Xinxin , Liu Liqiang , Song Shanshan , Kuang Hua , Xu Chuanlai , Wu Xiaoling
Published: September 2022

The visual cut-off values of the LFIA strip for abscisic acid in food samples were 5 ng mL−1 as observed by the naked eye.
Exciton-dominant photoluminescence of MoS2 by a functionalized substrate
Authors: Ji Eunji , Yang Kyungmin , Shin June-Chul , Kim Youngbum , Park Jin-Woo , Kim Jeongyong , Lee Gwan-Hyoung
Published: September 2022

A photoluminescence mapping image of monolayer (1L) MoS2 clearly shows the difference in PL intensity at the boundary between bare SiO2 and plasma-treated SiO2 (3 min).
A synergistic chemodynamic–photodynamic-photothermal therapy platform based on biodegradable Ce-doped MoOxnanoparticles
Authors: Li Danyang , Ha Enna , Zhang Jingge , Wang Luyang , Hu Junqing
Published: September 2022

Biodegradable Ce-doped MoOxnanoparticles were designed for tumor CDT/PDT/PTT synergistic therapy in the NIR-II biowindow.
Non-precious transition metal single-atom catalysts for the oxygen reduction reaction: progress and prospects
Authors: Jiao Penggang , Ye Donghao , Zhu Chunyou , Wu Shuai , Qin Chunling , An Cuihua , Hu Ning , Deng Qibo
Published: September 2022

This review summarizes the research progress of non-precious transition metal single-atom catalysts (NPT-SACs) for the cathode of metal–air batteries and fuel cells, and discusses how to improve the ORR performance of NPT-SACs.
Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation
Authors: Wu Zhuoran , Setyawati Magdiel Inggrid , Lim Hong Kit , Ng Kee Woei , Tay Chor Yong
Published: September 2022

Exposure to non-cytotoxic doses of engineered nanomaterials induce reactive oxygen species stress response cascades in human intestinal cancer cells to resist chemotherapeutics.
In situ implanting MnO nanoparticles into carbon nanorod-assembled microspheres enables performance-enhanced room-temperature Na–S batteries
Authors: Huang Xiang Long , Xiang Pan , Liu Hanwen , Feng Chi , Zhang Shaohui , Tian Ziqi , Liu Hua Kun , Dou Shi Xue , Wang Zhiming
Published: September 2022

In situ implanting MnO fine nanoparticles into carbon nanorod-assembled microspheres enables improved electrode stability and electrochemical performance via structural and compositional synergy.
Aptamer-based colorimetric detection of the DNA damage marker 8-oxo-dG using cysteamine-stabilised gold nanoparticles
Authors: Sakonsinsiri Chadamas , Puangmali Theerapong , Sreejivungsa Kaniknun , Koowattanasuchat Sireemas , Thanan Raynoo , Chompoosor Apiwat , Kulchat Sirinan , Sithithaworn Paiboon
Published: September 2022

A colorimetric assay based on cysteamine-stabilized AuNPs and anti-8-oxo-dG aptamers for the detection of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), which is a critical DNA damage marker, was developed.
RGD peptide-based lipids for targeted mRNA delivery and gene editing applications
Authors: Qin Jingya , Xue Lulu , Gong Ningqiang , Zhang Hanwen , Shepherd Sarah J. , Haley Rebecca M. , Swingle Kelsey L. , Mitchell Michael J.
Published: September 2022

We developed RGD peptide based ionizable lipids, which can be formulated into LNPs for integrin-dependent targeted mRNA delivery and gene editing applications.
Calix[4]pyrrolato gallate: square planar-coordinated gallium(iii) and its metal–ligand cooperative reactivity with CO2 and alcohols
Authors: Sigmund Lukas M. , Engels Eliane , Richert Nick , Greb Lutz
Published: September 2022

Ideally square-planar coordinated gallium(iii) species is isolated and fully characterized. Spontaneous metal–ligand cooperative reactivity towards CO2 is observed, while OH-bond activation of alcohols can be triggered by protonation of the ligand.
Stereomutation and chiroptical bias in the kinetically controlled supramolecular polymerization of cyano-luminogens
Authors: López-Gandul Lucía , Naranjo Cristina , Sánchez Cecilia , Rodríguez Rafael , Gómez Rafael , Crassous Jeanne , Sánchez Luis
Published: September 2022

The emissive features of supramolecular polymers formed by cyano-luminogens depends on the nature of the central aromatic unit. Intramolecular H-bonded species influence the chiroptical properties and the resulting aggregated species can be kinetically controlled.
Enhanced short time peak in four-point dynamic susceptibility in dense active glass-forming liquids
Authors: Dey Subhodeep , Mutneja Anoop , Karmakar Smarajit
Published: September 2022

Active glassy systems are simple model systems that imitate complex biological processes. This study provides a measure to obtain net activity in the supercooled active systems by observing the enhanced vibrational peak in the four-point dynamic susceptibility.
Plasmonic platinum nanoparticles–tungsten oxide nanoarchitectures as visible light photocatalysts for highly efficient overall water splitting
Authors: Gong Leibo , Chu Qingyun , Liu Xinyu , Tan Yiwei
Published: September 2022

Plasmon-enhanced Pt–WO3·0.5H2O–WO3 photocatalysts were prepared for photocatalytic overall water splitting under visible light and simulated sunlight irradiation. Exceptional STH efficiency (7.6%) and AQEs of higher than 10% have been achieved.
Infrared emitting and absorbing conjugated polymer nanoparticles as biological imaging probes
Authors: Honeybone Daniel , Peace Hannah , Green Mark
Published: September 2022

We discuss the synthesis of infrared-emitting conjugated polymer nanoparticles and their use in biological imaging. The image shows the vasculature of a mouse brain imaged with conjugated polymer nanoparticles (M. Liu et al., Angew. Chem., Int. Ed., 2021, 60, 983–989).
Self-surfactant room-temperature synthesis of morphology-controlled K0.3Bi0.7F2.4 nanoscintillators
Authors: Chen Dongxun , Liang Yanjie , Miao Shihai , Shan Xihui , Wang Xiaojia , Wang Weili , Zhang Yuhai , Bi Jianqiang , Tang Dongqi
Published: September 2022

K0.3Bi0.7F2.4-based nanoscintillators with multiform morphologies are synthesized through an ultrafast (only 1 min) and aqueous-phase chemical method at room temperature, which exhibit great potential for X-ray detection and imaging applications.
Shielding effect and compensation defect study on Na3Sc2(PO4)y:Eu2+,3+ (y = 2.6–3.0) phosphor by anion-group-induced phase transition
Authors: Tsai Yi-Ting , Huang Yu Shu , Majewska Natalia , Mahlik Sebastian , Muchlis Andi Magattang Gafur , Huang Yu-Kai , Huang Yu Lun , Lin Bi-Hsuan , Su Chaochin , Lin Chun Che
Published: September 2022

The study designs an anion-group-induced method to study the protection mechanism of the Eu-doped phosphor activator, where Eu2+ (β-phase) transforms to Eu3+ (γ-phase) with the decrease in the anion group for shielding effect and compensation defect.
Gas phase Elemental abundances in Molecular cloudS (GEMS)
Authors: Fuente Asunción ,   the GEMS IRAM 30m Large Program team
Published: September 2022

Gas phase Elemental abundances in Molecular CloudS (GEMS) is an IRAM 30m Large Program aimed at determining the elemental abundances of carbon (C), oxygen (O), nitrogen (N), and sulphur (S) in a selected set of prototypical star forming filaments. Elemental abundances have a key role in the star formation process by driving the gas cooling rate and the gas ionization degree. Defining elemental abundance as the amount of a given atom in volatiles, the elemental abundances of C, O, and N in the interstellar medium are currently known within a factor of a few. However, the elemental abundance of S remains uncertain by several orders of magnitude, and its determination is one of the most challenging goals of this program. This is a review of the observational, theoretical, and modeling effort that GEMS team is doing to improve our knowledge of the sulphur chemistry. Our results suggest that the sulphur elemental abundance depends on the local physical conditions and the star formation activity in the environment.
A Cloud-Scale View of the Molecular Gas Disk in the Whirlpool Galaxy and Beyond
Authors: Schinnerer Eva , Pety Jérôme , Bešlić Ivana , Eibensteiner Cosima , Stuber Sophia , Leroy Adam , Hughes Annie , Usero Antonio , Bigiel Frank ,   PAWS & PHANGS Collaborations
Published: September 2022

The nearby galaxy M51 (also known as the Whirlpool galaxy) hosts an iconic grand-design spiral pattern and both IRAM facilities conducted the first cloud-scale (∼50 pc resolution) survey of the molecular gas reservoir across a the disk of a massive star-forming galaxy (PAWS, PdBI+30m Arcsecond Whirlpool galaxy Survey) using the CO(1-0) line emission. PAWS showed that the various properties of the giant molecular cloud (GMC) population vary with galactic environment (center/bar, spiral arms, inter-arm). Recent observations of a ∼1000 pointing mosaic of the nearby late-type spiral galaxy IC342 using NOEMA resolved its GMC population at ∼70 pc resolution and find consistent trends. Investigation of the dense molecular gas phase at cloud-scales using tracers such as HCN(1-0) confirms the trends seen in kpc-scale surveys, namely that the dense gas star formation efficiency inn general apparently anticorrelates with the inferred dense gas fraction. Multi-line studies of the molecular gas in the galactic disks of nearby galaxies such as the ongoing large NOEMA+30m program to map the dense molecular gas phase in GMCs in the central part of M51 will allow for gaining new insights of the properties of this important molecular gas phase.
Molecules from evolved stars and their role in the cycle of the ISM
Authors: Agúndez Marcelino
Published: September 2022

The ejecta of evolved stars are among the most efficient chemical laboratories in the Universe. Many of the chemical compounds synthesized in these environments probably travel along the interstellar medium and may be ultimately delivered to planets. However, we still do not understand many of the chemical processes at work during the evolution from the AGB phase to the PN. Here we review key aspects of our current understanding of the chemistry of AGB and post-AGB envelopes, highlighting the issues that are yet to be understood.
LEGO: A 3 mm molecular line study covering 100 pc of one of the most actively star-forming portions in the Milky Way
Authors: Barnes Ashley , Kauffmann Jens , Bigiel Frank ,   LEGO collaboration
Published: September 2022

The current generation of high-sensitivity (sub)mm-telescopes such as the IRAM-30m and NOEMA have allowed the emission from molecular lines to become a major tool for studying the physical, kinematic and chemical properties of extragalactic systems. However, we need to develop a detailed understanding of emission lines in Milky Way molecular clouds before we can exploit extragalactic line emission data to its full potential. With this in mind, the IRAM-30m large project “Line Emission to assess Galaxy Observations” (LEGO) aims at developing a comprehensive picture of how 3mm-band emission lines in MilkyWay molecular clouds depend on a variety of environmental factors. In this proceeding, I will focus on our recent detailed investigation of the W49 massive star-forming region published in Barnes et al. 2020 [1].
Feedback from young stars, the molecular signature of shocks and outflows
Authors: Gusdorf Antoine
Published: September 2022

Why do we study shocks ? Because they are there. Shocks are ubiquitous in the interstellar medium (ISM), where they constitute a major source of energy injection, together with photons and cosmic rays (CRs). Galactic shocks, and converging flows at the basis of the formation of molecular clouds and filaments, are examples of interstellar shocks. Shock waves are also generated during the birth, life and death of stars in the form of jets and protostellar outflows, stellar winds and supernovae and supernova remnants (SNRs). Hence, they are a major route of feedback of stars on galaxies. As such, they are a proficient tool to better understand the cycle of matter and energy in galaxies, but also the formation of stars. In this review, I will describe the recent advances on the study of shocks that can be observed and characterized with the IRAM instruments, with emphasis on the study of protostellar jets and outflows.
The QUIJOTE line survey of TMC-1
Authors: Cernicharo José , Agúndez Marcelino , Cabezas Carlos , Marcelino Nuria , Tercero Belén , Pardo Juan Ramón , Fuentetaja Raúl , de Vicente Pablo
Published: September 2022

We present the recent results obtained with the QUIJOTE line survey of the cold dark core TMC-1. The observations have been carried out with the YEBES 40m radio telescope (see Figure 1) in the Q-band (31-50 GHz). A new set of receivers have been installed in the telescope within the frame of the ERC synergy Nanocosmos project that allows to cover the whole 31-50 GHz band in dual polarization [1]. The spectral resolution is 38.15 kHz. The sensitivity achieved so far varies between 0.12 and 0.25 mK, and allows to search for new molecules in a line by line (no stacking) detection procedure. These new data have permitted to detect the many relatively small protonated species of abundant molecules and eight sulfur-bearing species. The most exciting result is the detection of hydrocarbon chains and cycles with low permanent dipole moment, such as CH2CHCCH, CH2CCHCCH, the propargyl radical (C3H3), cyclopentadiene, indene (the first PAH detected in space), ortho-benzyne and two ethynyl derivatives of cyclopentadiene (c-C5H5CCH) ([2–7]). We have found that the gas-phase chemistry of hydrocarbons in TMC-1 has to be revisited in depth.
Algorithms for processing self-powered neutron detector signals important for determination of local parameters in each part of the VVER core
Authors: Lys Stepan , Kanyuka Alexandr
Published: September 2022

These investigation findings prove the possibility of a engineering solution for VVER core automatic protection during operation in both nominal and transient conditions within ICIS using local parameters (i.e. linear heat power of the most stressed fuel rod, departure from nucleate boiling ratio). Such engineering solution will be implemented by safety system software-hardware (PTK-Z) on the basis of signals coming from in-core neutron flux detectors, temperature sensors, primary coolant flow and coolant pressure transducers. The article presents the following: a list of in-core neutron flux detectors, a list of transducers of primary coolant monitoring for thermal engineering conditions (temperature, flow rate, pressure), whose signals are delivered to the terminals of instrumentation gauges (PTK-Z) for the purpose of actuating safety actions in accordance with local parameters. The paper shows arrangement of in-core neutron flux detector equipment, above view of self-powered neutron detector (SPND) location in safety channels, axial arrangement of SPND along the core, algorithms for processing SPND signals important for determination of local parameters in each part of the core in both normal and abnormal operation conditions.
Comparison of Subungual Glomus Tumours in Terms of Nail Aesthetics
and Recurrence According to Size and Location in the Germinal or Sterile
Matrix
Authors: Orman Osman , Onal Ayberk , Baydar Mehmet , Sencan Ayse , Özkan Bilge , Öztürk Kahraman
Published: September 2022

Purpose The aim of this retrospective study was to investigate the effect
of subungual glomus tumour size and localization in the germinal or sterile
matrix on tumour recurrence and aesthetic outcomes.

Patients and Methods From 35 patients who underwent surgery for a
subungual glomus tumour between February 2013 and February 2020, 26 patients
– 17 women and 9 men – with 27 subungual glomus tumours
fulfilled the inclusion criteria. The average age was 37.3 (22–58)
years. According to the patients’ surgical notes and preoperative
magnetic resonance images 14 tumours were located in the sterile, 13 in the
germinal matrix, and the mean size of the glomus tumours located in the germinal
matrix was 4.9±1.7 mm, in the sterile matrix
3.6±1.0 mm. At the postoperative 12th month follow-up visit nail
aesthetic was evaluated objectively according to Zook’s fingernail
appearance scoring. In addition, patients were asked to evaluate the pain and
nail appearance in the involved finger by VAS (Visual Analog Scale
0–10). Patients who experienced recurrence were noted.

Results No significant Zook’s fingernail appearance score
differences were observed between germinal and sterile matrix groups
(p=0.097). Comparison of VAS score for pain and VAS score for nail
appearance between the two groups also yielded similar values (p=0.449
and 0.395, respectively). The recurrence rate was similar at both locations
(p=0.557) with 3 recurrences in the germinal, and 2 in the sterile
matrix group. There was no relation between tumour size, Zook’s
fingernail appearance score (p=0.874) and recurrence (p=0.784).
The observed germinal matrix glomus tumours were significantly larger than the
sterile matrix tumours (p=0.031).

Conclusion Neither subungual glomus tumour size nor localization in the
germinal or sterile matrices has different effects on nail appearance and
recurrence.
Liebe Leserinnen und Leser der Klinischen Neurophysiologie,
Authors: Dafotakis Manuel
Published: September 2022

ich begrüße Sie sehr herzlich zum Schwerpunktheft
„Toxisches“.
Medikamentös-induzierte Polyneuropathien durch
Chemotherapeutika und Antiinfektiva
Authors: Achenbach Pascal , Block Frank , Dafotakis Manuel
Published: September 2022

Polyneuropathien können durch zahlreiche Wirkstoffe hervorgerufen oder
aggraviert werden. Insbesondere die Chemotherapeutika-induzierte Polyneuropathie
(CIPN) ist im Alltag von hoher Relevanz. Jedoch kann auch der Einsatz von
Antiinfektiva zu neuropathischen Beschwerden führen. Im Folgenden soll
ein Überblick über die wichtigsten mit Polyneuropathien
assoziierten Wirkstoffe der Substanzklassen sowie die klinischen Charakteristika
gegeben werden.
Idiopathische rekurrierende Perikarditis
Authors: Krusche Martin , Ruffer Nikolas
Published: September 2022

Die idiopathische rekurrierende Perikarditis (IRP) umfasst rezidivierende Perikarditis-Episoden, für die keine anderen Ursachen bzw. Auslöser gefunden werden können. Aufgrund ihres inflammatorischen Charakters (meist akute Schmerzattacken mit deutlich erhöhten serologischen Entzündungszeichen sowie gutem Ansprechen auf Colchicin und/oder Interleukin-1-Blockade) mit Rezidivneigung wird die Erkrankung auch als eigenständige autoinflammatorische Erkrankung angesehen. Darüber hinaus können vergleichbare Episoden auch bei anderen autoinflammatorischen Erkrankungen wie dem familiären Mittelmeerfieber (FMF) oder TNF-Rezeptor-assoziierten periodischen Syndrom (TRAPS) auftreten. Der Artikel gibt einen Überblick über die Klinik, Pathophysiologie und Therapie der IRP.
Hypoglykämie unter SGLT2-Inhibition bei einem Patienten mit HFrEF ohne Diabetes mellitus
Authors: Schmidt Hendrik , Schlitt Axel
Published: September 2022

Anamnese Bei einem 79-jährigen wurde eine HFrEF (heart failure with reduced ejection fraction) mit einer linksventrikulären Ejektionsfraktion von 25–30 % nachgewiesen. Zur weiteren Behandlung wurde eine kardiologische Rehabilitationsmaßnahme durchgeführt.

Klinischer Befund Bei Antritt der AHB klagte der Patient über Luftnot bei geringer Belastung entsprechend dem Stadium NYHA III. Die medikamentöse Therapie beinhaltete Empagliflozin 10 mg, Sacubitril/Valsartan 24/26 mg, Edoxaban 60 mg, Torasemid 5 mg, Verapamil 80 mg sowie Amiodaron 200 mg.

Untersuchungen Im Blutzucker-Tagesprofil zeigten sich Hypoglykämien mit Werten < 3,7 mmol/l (< 67 mg/dl). Nach Rücksprache mit dem Patienten traten diese unter normaler Nahrungsaufnahme auf und waren in Form von Schwindel im Zeitraum der Hypoglykämien symptomatisch.

Diagnose Symptomatische Hypoglykämie unter SGLT2(sodium-glucose linked transporter 2)-Inhibitor-Therapie bei einem Patienten mit HFrEF ohne Diabetes mellitus.

Therapie und Verlauf Die Therapie mit Empagliflozin wurde beendet und ein erneutes Blutzucker-Tagesprofil durchgeführt – dieses zeigte keine hypoglykämischen Werte mehr.

Folgerung Der hier vorgestellte Fall sensibilisiert für die unter SGLT2-Inhibitoren in Studien sehr selten auftretende Nebenwirkung der Hypoglykämie bei Patienten mit HFrEF ohne Vorliegen eines Diabetes mellitus.
Der Einfluss der simulierten Endgelenksversteifung auf die Bewegung
und Kraftentwicklung des Fingers
Authors: Bauknecht Simon , Mentzel Martin , Vergote Daniel , Andreas Myriam , Moeller Richard-Tobias
Published: September 2022

Hintergrund Die Versteifung des Fingerendgelenks ist eine bewährte
Methode zur Behandlung der Endgelenksarthrose. Da es sich bei der oberen
Gliedmaße um eine Gliederkette handelt, die von vernetzten,
gelenkübergreifenden Muskel-Sehnen-Einheiten bewegt wird, sind durch die
Versteifung eines Gelenks Auswirkungen auf die Beweglichkeit und die
Kraftentwicklung beim Greifen zu erwarten. Hierzu fehlt bislang eine
quantitative Analyse in Echtzeit.

Material und Methoden Die Bewegung der Finger und die Kraftentwicklung
beim Greifen wurde an 19 gesunden Probanden mit simulierter Versteifung eines
Fingerendgelenks mit dem TUB-(Technische Universität
Berlin)-Sensorhandschuh beim Faustschluss und bei zwei Varianten des Kraftgriffs
im Vergleich zum physiologischen Griff dynamisch gemessen und quantitativ
analysiert.

Ergebnisse Beim physiologischen Faustschluss betrug der mittlere
Beugungswinkel am Grundgelenk 71,5°, am Mittelgelenk 76,8° und
am Endgelenk 37,3°. Bei simulierter Endgelenksversteifung fiel er am
Mittelgelenk auf 49,6°, während er am Grundgelenk auf
77,3° leicht zunahm. Ebenso verhielt es sich bei den Kraftgriffen. Beim
Kraftgriff I beliefen sich die Winkel unter physiologischen Bedingungen auf
18,3° am Grund-, 39,6° am Mittel- und 42,6° am
Endgelenk. Bei simulierter Endgelenksversteifung stieg der Winkel am Grundgelenk
auf 28,4°, während er am Mittelgelenk auf 25,2° fiel.
Beim Kraftgriff II lagen die physiologischen Werte bei 30,9° am Grund-,
36,6° am Mittel- und 29,0° am Endgelenk. Bei simulierter
Endgelenksversteifung stieg der Winkel am Grundgelenk auf 34,4° und fiel
am Mittelgelenk auf 23,3°. Die bei den Kraftgriffen gemessenen
Kräfte verteilten sich unter physiologischen Bedingungen nahezu
gleichmäßig auf alle vier Strahlen. Bei simulierter
Endgelenksversteifung fiel die gemessene Kraft des betroffenen Fingers im Mittel
nur um bis zu 1,4%.

Schlussfolgerung Mit der vorliegenden Studie liegt erstmals eine
quantitative Analyse des Greifens bei simulierter Endgelenksarthrodese vor. Sie
zeigt das dynamische Zusammenspiel der Fingergelenke sowie der
Kraftverteilungsmuster an den einzelnen Strahlen der Hand in Echtzeit.
Die Therapie der Nahrungsverweigerung und der Anorexia nervosa in
deutschsprachigen Psychiatrie-Lehrbüchern der vergangenen 200
Jahre
Authors: Bergner Lukas , Himmerich Hubertus , Steinberg Holger
Published: September 2022

Die vorliegende Arbeit zeigt auf, wie die Therapie der Anorexia nervosa (AN) und
der Nahrungsverweigerung in den führenden Lehrbüchern der
deutschsprachigen Schulpsychiatrie in den vergangenen 200 Jahren vermittelt
wurde. Hierfür wurden 18 Lehrwerke bedeutender Psychiater
ausgewählt. Diese wurden strukturiert analysiert, um jeweils das an
Medizinstudenten und junge Nervenärzte an deutschsprachigen
Universitäten weitergegebene Wissen zur Thematik zu ermitteln. Es zeigte
sich, dass die AN erst Ende des 20. Jahrhunderts als ein eigenständiges
Krankheitsbild erfasst und vermittelt wurde. Doch bereits zuvor wurden der
Nahrungsverweigerung als Symptom eine große Bedeutung beigemessen und
mannigfaltige Therapiekonzepte entwickelt. Beginnend im 19. Jahrhundert mit der
Zwangsernährung mittels Magensonden wurden später
Pharmakotherapien entwickelt sowie spezielle Diäten diskutiert.
Bemerkenswert ist, dass bereits seit den Anfängen der akademischen
Psychiatrie besondere Verhaltensweisen mit dem Patienten und eine
Vorbildfunktion des Therapeuten als „Psychotherapie im weiteren
Sinne“ beschrieben wurden, um Patienten zum Essen zu animieren. Die
Therapie der Nahrungsverweigerung mittels strukturierter Psychotherapien wurde
erst Ende des 20. Jahrhunderts mit der Anerkennung der AN als
eigenständige Krankheitsentität etabliert. Hierbei zeigte sich
im Verlauf der letzten Jahrzehnte ein grundlegender Wandel im
Verständnis von möglichen auslösenden Faktoren dieser
Erkrankung und möglichen psychotherapeutischen Interventionen.
The course of pain and dysphagia after radiofrequency ablation for Barrett’s esophagus-related neoplasia
Authors: Overwater Anouk , Elias Sjoerd G. , Schoon Erik J. , Bergman Jacques J. G. H. M. , Pouw Roos E. , Weusten Bas L. A. M.
Published: September 2022

Background Radiofrequency ablation (RFA) is effective for eradication of Barrett’s esophagus (BE) neoplasia, but little is known on the course of pain and dysphagia after RFA. We aimed to describe the course of post-RFA symptoms and to identify possible associated risk factors.

Methods In this multicenter, observational cohort study, all RFA procedures registered in a prospective database were included. Patient and treatment characteristics were collected from medical records and patients self-registered post-procedural symptoms in electronic symptom diaries for 14 days. Mixed model regression was used for the analyses.

Results In total, 255 diaries were completed. Post-RFA pain was reported for 95 % (95 %CI 93–98) of procedures (median duration 14 days; 25th–75th percentiles [p25–p75] 11–14) and major pain for 64 % (95 %CI 58–69; median duration 8 days, p25–p75 3–13). Post-procedural pain significantly increased with BE length, younger age, and no prior ablation. Dysphagia was present after 83 % (95 %CI 79–88) of procedures (median duration 13 days, p25–p75 9–14). The risk of dysphagia decreased with age and increased when patients experienced more pain.

Conclusions RFA treatment for BE-related neoplasia seems a significant burden for patients, and post-procedural symptoms should be taken into account when counseling patients before starting endoscopic eradication therapy.
Cranial Base Reconstruction and Secondary Frontal Advancement for Meningoencephalocele Following LeFort III Osteotomy in a Patient with Crouzon Syndrome: Case Report
Authors: Jeon Sungmi , Kim Yumin , Phi Ji Hoon , Chung Jee Hyuk
Published: September 2022

Patients with Crouzon syndrome have increased risks of cerebrospinal fluid rhinorrhea and meningoencephalocele after LeFort III osteotomy. We report a rare case of meningoencephalocele following LeFort III midface advancement in a patient with Crouzon syndrome. Over 10 years since it was incidentally found during transnasal endoscopic orbital decompression, the untreated meningoencephalocele eventually led to intermittent clear nasal discharge, frontal headache, and seizure. Computed tomography and magnetic resonance imaging demonstrated meningoencephalocele in the left frontal-ethmoid-maxillary sinus through a focal defect of the anterior cranial base. Through bifrontal craniotomy, the meningoencephalocele was removed and the anterior cranial base was reconstructed with a pericranial flap and split calvarial bone graft. Secondary frontal advancement was concurrently performed to relieve suspicious increased intracranial pressure, limit visual deterioration, and improve the forehead shape. Surgeons should be aware that patients with Crouzon syndrome have the potential for an unrecognized dural injury during LeFort III osteotomy due to anatomical differences such as inferior displacement and thinning of the anterior cranial base.
Organocatalytic Asymmetric Oxa-Michael–Michael Reaction of 3-Aryl-2-Nitroprop-2-Enols with Unsaturated Pyrazolones: Synthesis of Spirotetrahydropyranopyrazolones
Authors: Pan Subhas Chandra , Bania Nimisha , Barman Dipankar
Published: September 2022

An organocatalytic asymmetric oxa-Michael–Michael reaction of 3-aryl-2-nitroprop-2-enols with alkylidene pyrazolones has been developed. This report describes the first use of a 3-aryl-2-nitroprop-2-enol as an O-nucleophile in enantioselective catalysis. With 10 mol% of a quinine-derived squaramide catalyst, a variety of spirotetrahydropyranopyrazolones were obtained in moderate yields, excellent diastereomeric ratios, and high to excellent enantioselectivities under mild reaction conditions.
Reproducibility, Repeatability, and Correlation of Central Corneal Thickness Measurement with the Pentacam Scheimpflug System and Ultrasound Pachymetry
Authors: Macias-Rodriguez Yolanda , Ramos-Dávila Eugenia M. , Ruiz-Lozano Raul E. , Reyes-Arena Jose V. , Rivera-Alvarado I. Jocelyn , Hernandez-Camarena Julio C. , Rodriguez-Garcia Alejandro
Published: September 2022

Background/Aim The importance of an accurate determination of central corneal thickness (CCT) relies on its diagnostic and therapeutic implications in glaucoma, corneal ectasias, corneal edema and endothelial function monitoring, and refractive surgery suitability, among others. We aimed to analyze the repeatability, reproducibility, correlation, and laterality variations of CCT measurements performed with the Pentacam HR and the standard of care ultrasound A-scan (USP).

Methods A cross-sectional study including CCT measurements of healthy individuals was performed by three independent examiners with the Pentacam HR and USP. Intra-observer and inter-observer variations were calculated with intra-class correlation coefficients (ICCs). Bland-Altman plots and 95% limits of agreement (95% LoA) were used to assess the agreement between devices. Linear correlation was calculated with Pearsonʼs coefficient.

Results Thirty individuals (60 eyes), including 10 (33.3%) men and 20 (66.6%) women, with a mean age of 30.0 ± 9.1 years, were studied. No statistical differences were found in CCT measurements between Pentacam HR (range 500 – 609 µm) and USP (range 498 – 628 µm). There was a high degree of correlation in repeatability and reproducibility of each independent device (ICC > 0.90). Pearsonʼs correlation between 1 vs. 2, 2 vs. 3, and 3 vs. 1 Pentacam HR attempts were 0.914, 0.958, and 0.925, respectively (p < 0.001). Corresponding results for USP were 0.957, 0.957, and 0.943 (p < 0.001). The Pentacam HR tended to overestimate CCT by a mean difference of 3.77 µm (95% LoA, − 24.9 – 18.4). Right eyes were also overestimated (− 3.6 ± 14.1 µm) with the Pentacam HR device, whereas left eyes were underestimated (1.3 ± 11.1 µm).

Conclusions The Pentacam HR device provides reliable operator-independent estimates of CCT. Right eyes exhibited a tendency to overestimate with the Pentacam HR. We suspect this difference is due to USP underestimation related to patientsʼ position while performing the study. In clinically relevant scenarios, performing a third measurement and cautiously measuring right eyes can provide higher accuracy.
Improving the Quality of Electronic Medical Record Documentation: Development of a Compliance and Quality Program
Authors: Jedwab Rebecca M. , Franco Michael , Owen Denise , Ingram Anna , Redley Bernice , Dobroff Naomi
Published: September 2022

Background Introducing an electronic medical record (EMR) system into a complex health care environment fundamentally changes clinical workflows and documentation processes and, hence, has implications for patient safety. After a multisite “big-bang” EMR implementation across our large public health care organization, a quality improvement program was developed and implemented to monitor clinician adoption, documentation quality, and compliance with workflows to support high-quality patient care.

Objective Our objective was to report the development of an iterative quality improvement program for nursing, midwifery, and medical EMR documentation.

Methods The Model for Improvement quality improvement framework guided cycles of “Plan, Do, Study, Act.” Steps included design, pre- and pilot testing of an audit tool to reflect expected practices for EMR documentation that examined quality and completeness of documentation 1-year post-EMR implementation. Analysis of initial audit results was then performed to (1) provide a baseline to benchmark comparison of ongoing improvement and (2) develop targeted intervention activities to address identified gaps.

Results Analysis of 1,349 EMR record audits as a baseline for the first cycle of EMR quality improvement revealed five out of nine nursing and midwifery documentation components, and four out of ten medical documentation components' completion and quality were classified as good (>80%). Outputs from this work also included a framework for strategies to improve EMR documentation quality, as well as an EMR data dashboard to monitor compliance.

Conclusion This work provides the foundation for the development of quality monitoring frameworks to inform both clinician and EMR optimization interventions using audits and feedback. Discipline-specific differences in performance can inform targeted interventions to maximize the effective use of resources and support longitudinal monitoring of EMR documentation and workflows. Future work will include repeat EMR auditing.
Gender affirming hormone therapy dosing behaviors among transgender and nonbinary adults
Authors: Restar Arjee , Dusic E. J. , Garrison-Desany Henri , Lett Elle , Everhart Avery , Baker Kellan E. , Scheim Ayden I. , Beckham S. Wilson , Reisner Sari , Rose Adam J. , Mimiaga Matthew J. , Radix Asa , Operario Don , Hughto Jaclyn M. W.
Published: September 2022

Gender-affirming hormones have been shown to improve psychological functioning and quality of life among transgender and nonbinary (trans) people, yet, scant research exists regarding whether and why individuals take more or less hormones than prescribed. Drawing on survey data from 379 trans people who were prescribed hormones, we utilized multivariable logistic regression models to identify factors associated with hormone-dosing behaviors and content analysis to examine the reasons for dose modifications. Overall, 24% of trans individuals took more hormones than prescribed and 57% took less. Taking more hormones than prescribed was significantly associated with having the same provider for primary and gender-affirming care and gender-based discrimination. Income and insurance coverage barriers were significantly associated with taking less hormones than prescribed. Differences by gender identity were also observed. Addressing barriers to hormone access and cost could help to ensure safe hormone-dosing behaviors and the achievement trans people’s gender-affirmation goals.
Ultra-precision machining of cerium-lanthanum alloy with atmosphere control in an auxiliary device
Authors: Zhao Chenyu , Wu Shengjie , Lai Min
Published: September 2022

Cerium–lanthanum alloys are the main component of nickel–metal hydride batteries, and they are thus an important material in the green-energy industry. However, these alloys have very strong chemical activity, and their surfaces are easily oxidized, leading to great difficulties in their application. To improve the corrosion resistance of cerium–lanthanum alloys, it is necessary to obtain a nanoscale surface with low roughness. However, these alloys can easily succumb to spontaneous combustion during machining. Currently, to inhibit the occurrence of fire, machining of this alloy in ambient air needs to be conducted at very low cutting speeds while spraying the workpiece with a large amount of cutting fluid. However, this is inefficient, and only a very limited range of parameters can be optimized at low cutting speeds; this restricts the optimization of other cutting parameters. To achieve ultraprecision machining of cerium–lanthanum alloys, in this work, an auxiliary machining device was developed, and its effectiveness was verified. The results show that the developed device can improve the cutting speed and obtain a machined surface with low roughness. The device can also improve the machining efficiency and completely prevent the occurrence of spontaneous combustion. It was found that the formation of a build-up of swarf on the cutting tool is eliminated with high-speed cutting, and the surface roughness (Sa) can reach 5.64 nm within the selected parameters. Finally, the oxidation processes of the cerium–lanthanum alloy and its swarf were studied, and the process of the generation of oxidative products in the swarf was elucidated. The results revealed that most of the intermediate oxidative products in the swarf were Ce3+, there were major oxygen vacancies in the swarf, and the final oxidative product was Ce4+.
Cohomology and deformations of weighted Rota–Baxter operators
Authors: Das Apurba
Published: September 2022

Weighted Rota–Baxter operators on associative algebras are closely related to modified Yang–Baxter equations, splitting of algebras, and weighted infinitesimal bialgebras and play an important role in mathematical physics. For any λ ∈ k, we construct a differential graded Lie algebra whose Maurer–Cartan elements are given by λ-weighted relative Rota–Baxter operators. Using such characterization, we define the cohomology of a λ-weighted relative Rota-Baxter operator T and interpret this as the Hochschild cohomology of a suitable algebra with coefficients in an appropriate bimodule. We study linear, formal, and finite order deformations of T from cohomological points of view. Among others, we introduce Nijenhuis elements that generate trivial linear deformations and define a second cohomology class to any finite order deformation, which is the obstruction to extend the deformation. In the end, we also consider the cohomology of λ-weighted relative Rota–Baxter operators in the Lie case and find a connection with the case of associative algebras.
Characterization of interfacial stiffness in film–substrate structure using Scholte waves
Authors: Ye Tianming , Hu Wenxiang
Published: September 2022

This study uses Scholte waves to characterize the interfacial stiffness of a film–substrate structure. A theoretical model was formulated to investigate the dispersion relationships of Scholte waves in immersed film–substrate structures, and simulations of different interfacial states ranging from perfect to weak bonds were performed. The numerical results showed that Scholte waves are sensitive to the variation in the interfacial stiffness, providing the possibility of using the Scholte waves to characterize the bond condition in the film–substrate structure. Experimental tests were conducted on bonded samples under different bond conditions to confirm the theoretical predictions, and the results showed the differences in the dispersion characteristics for different bonding states. The quantification of the interfacial stiffness coefficient between the film and substrate was realized using the inversion method, demonstrating the potential of Scholte waves to evaluate the interfacial properties of a bonded structure.
3D engineered neural co-culture model and neurovascular effects of marine fungi-derived citreohybridonol
Authors: Sokullu Emel , Polat İrem , Özkaya Ferhat Can , El-Neketi Mona , Ebrahim Weaam , Sarabi Misagh Rezapour , Sengul Gulgun , Tasoglu Savas
Published: September 2022

Marine-based biomolecules are emerging metabolites that have gained attention for developing novel biomaterials, drugs, and pharmaceutical in vitro platforms. Here, we developed a 3D engineered neural co-culture model via a 3D prototyped sliding frame-platform for multi-step UV lithography and investigated the neurovascular potential of citreohybridonol in neuroblastoma treatment. Citreohybridonol was isolated from a sponge-derived fungus Penicillium atrovenetum. The model was characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy analysis. Human umbilical cord vein endothelial cells (HUVECs) and neuroblastoma (SH-SY5Y) cell lines were encapsulated in gelatin methacrylate (GelMA) with and without citreohybridonol. The effect of citreohybridonol on the proliferation capacity of cells was assessed via cell viability and immunostaining assays. GelMA and 3D culture characterization indicated that the cells were successfully encapsulated as axenic and mixed with/without citreohybridonol. The cytotoxic test confirmed that the 3D microenvironment was non-toxic for cultural experiments, and it showed the inhibitory effects of citreohybridonol on SH-SY5Y cells and induced the proliferation of HUVECs. Finally, immunohistochemical staining demonstrated that citreohybridonol suppressed SH-SY5Y cells and induced vascularization of HUVECs in mixed 3D cell culture.
Quantification of Reynolds-averaged-Navier–Stokes model-form uncertainty in transitional boundary layer and airfoil flows
Authors: Chu Minghan , Wu Xiaohua , Rival David E.
Published: September 2022

It is well known that the Boussinesq turbulent-viscosity hypothesis can introduce uncertainty in predictions for complex flow features such as separation, reattachment, and laminar-turbulent transition. This study adopts a recent physics-based uncertainty quantification (UQ) approach to address such model-form uncertainty in Reynolds-averaged Naiver–Stokes (RANS) simulations. Thus far, almost all UQ studies have focused on quantifying the model-form uncertainty in turbulent flow scenarios. The focus of the study is to advance our understanding of the performance of the UQ approach on two different transitional flow scenarios: a flat plate and a SD7003 airfoil, to close this gap. For the T3A (flat-plate) flow, most of the model-form uncertainty is concentrated in the laminar-turbulent transition region. For the SD7003 airfoil flow, the eigenvalue perturbations reveal a decrease as well as an increase in the length of the separation bubble. As a consequence, the uncertainty bounds successfully encompass the reattachment point. Likewise, the region of reverse flow that appears in the separation bubble is either suppressed or bolstered by the eigenvalue perturbations. This is the first successful RANS UQ study for transitional flows.
Efficacy and application of the window-sliding ARIMA for daily and weekly wind speed forecasting
Authors: Sheoran Sarita , Pasari Sumanta
Published: September 2022

Accurate forecasting of renewable energy resources has a deep societal and environmental impact. In this work, we investigate the efficacy and applicability of the Window-Sliding ARIMA (WS-ARIMA) method for daily and weekly forecasting of wind speed. The WS-ARIMA technique with a fixed or variable window length belongs to the class of adaptive models. Particularly, the sliding windows of fixed length are popular in the areas of finance, energy, and traffic management, where the dataset of necessity exhibits a seasonal pattern. To carry out the proposed analysis, the following processes were done: (1) we first perform a stationarity test on the wind speed data and observe weak stationarity; (2) we then apply a grid search method to obtain the optimal parameters of the ARIMA model; (3) we implement the WS-ARIMA method for both daily and weekly wind speed data and compare the results with the conventional ARIMA model, and (4) finally, we perform a residual analysis as a post processing step to examine any systematic bias in the implemented models. The experimental results based on 15 years (2000–2014) of daily and weekly wind speed data collected at four different locations in India reveal that the WS-ARIMA method consistently outperforms the conventional ARIMA method. The inclusion of window sliding in ARIMA has resulted in the overall RMSE reduction up to 75% in daily wind speed data and 50% in the weekly data. Therefore, we recommend the WS-ARIMA model as one of the potential techniques in wind speed forecasting at daily and weekly time horizons.
The quantum dynamics of H2 on Cu(111) at a surface temperature of 925 K: Comparing state-of-the-art theory to state-of-the-art experiments
Authors: Smits B. , Somers M. F.
Published: September 2022

We present results of our recently expanded static corrugation model (SCM) approach that included the relevant surface temperature effects, applied to the dissociative chemisorption reaction of H2 on a Cu(111) surface. The reaction and rovibrationally elastic scattering probabilities that we obtain at a quantum dynamical (QD) level, as an average of many statically distorted surface configurations, show great agreement with those of a dynamic surface model, which reinforces the validity of the sudden approximation inherent to the SCM. We further investigate several simple methods of binning the final rovibrational state of quasi-classical dynamics simulations, to find those best suited to reproduce the QD results for our system. Finally, we show that the SCM obtained results reproduce experimental dissociation curves very well, when the uncertainty in experimental saturation values is taken into account. Some indication of a slow channel, so far only observed in experiment, can also be found at low incidence energies, although more rigorous QD simulations are required to reduce the noise inherent to our propagation methods.
The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved
Authors: Shrivastava Aseem , Sandhof Carl Alexander , Reinle Kevin , Jawed Areeb , Ruger-Herreros Carmen , Schwarz Dominic , Creamer Declan , Nussbaum-Krammer Carmen , Mogk Axel , Bukau Bernd
Published: September 2022

The chaperone-mediated sequestration of misfolded proteins into inclusions is a pivotal cellular strategy to maintain proteostasis in Saccharomyces cerevisiae, executed by small heat shock proteins (sHsps) Hsp42 and Btn2. Direct homologs of Hsp42 and Btn2 are absent in other organisms, questioning whether sequestration represents a conserved proteostasis strategy and, if so, which factors are involved. We examined sHsps from Escherchia coli, Caenorhabditis elegans, and humans for their ability to complement the defects of yeast sequestrase mutants. We show that sequestration of misfolded proteins is an original and widespread activity among sHsps executed by specific family members. Sequestrase positive C. elegans’ sHsps harbor specific sequence features, including a high content of aromatic and methionine residues in disordered N-terminal extensions. Those sHsps buffer limitations in Hsp70 capacity in C. elegans WT animals and are upregulated in long-lived daf-2 mutants, contributing to lifespan extension. Cellular protection by sequestration of misfolded proteins is, therefore, an evolutionarily conserved activity of the sHsp family.