bluuebunny/crossref_metadata_2025 huggingface dataset:
Controlled experiment finds no detectable citation bump from Twitter promotion
Authors: Branch Trevor A. , Cȏté Isabelle M. , David Solomon R. , Drew Joshua A. , LaRue Michelle , Márquez Melissa C. , Parsons E. C. M. , Rabaiotti D. , Shiffman David , Steen David A. , Wild Alexander L.
Published: March 2024

Multiple studies across a variety of scientific disciplines have shown that the number of times that a paper is shared on Twitter (now called X) is correlated with the number of citations that paper receives. However, these studies were not designed to answer whether tweeting about scientific papers causes an increase in citations, or whether they were simply highlighting that some papers have higher relevance, importance or quality and are therefore both tweeted about more and cited more. The authors of this study are leading science communicators on Twitter from several life science disciplines, with substantially higher follower counts than the average scientist, making us uniquely placed to address this question. We conducted a three-year-long controlled experiment, randomly selecting five articles published in the same month and journal, and randomly tweeting one while retaining the others as controls. This process was repeated for 10 articles from each of 11 journals, recording Altmetric scores, number of tweets, and citation counts before and after tweeting. Randomization tests revealed that tweeted articles were downloaded 2.6–3.9 times more often than controls immediately after tweeting, and retained significantly higher Altmetric scores (+81%) and number of tweets (+105%) three years after tweeting. However, while some tweeted papers were cited more than their respective control papers published in the same journal and month, the overall increase in citation counts after three years (+7% for Web of Science and +12% for Google Scholar) was not statistically significant (p > 0.15). Therefore while discussing science on social media has many professional and societal benefits (and has been a lot of fun), increasing the citation rate of a scientist’s papers is likely not among them.
Cohort profile: Life-course experiences and pregnancy (LEAP)–A retrospective pregnancy cohort for life-course reproductive health research
Authors: Mason Susan M. , Farkas Kriszta , Friedman Jessica K. , Gerlach Anne , Johnson Sydney T. , Tavernier Rebecca Emery , Bodnar Lisa M. , Neumark-Sztainer Dianne
Published: March 2024

Background

Life course factors may be associated with pre-pregnancy body mass index and gestational weight gain; however, collecting information on pre-pregnancy exposures and pregnancy health in the same cohort is challenging.

Objectives

The Life-course Experiences And Pregnancy (LEAP) study aims to identify adolescent and young adult risk factors for pre-pregnancy weight and gestational weight gain (GWG). We built upon an existing cohort study to overcome challenges inherent to studying life course determinants of pregnancy health.

Population

Participants in an ongoing prospective cohort study of weight-related health who identified as women.

Design

Retrospective cohort study.

Methods

In 2019–2020, 1,252 women participating since adolescence in a cohort study of weight-related health were invited to complete an online reproductive history survey. Participants who reported a live birth were invited to release their prenatal, delivery, and postpartum medical records for validation of survey reports. Descriptive analyses were conducted to assess the characteristics of the overall cohort and the medical record validation subsample, and to describe adolescent and young adult characteristics of those with high (>80th percentile), moderate (20th-80th percentile), and low (<20th percentile) GWG z-score for gestational age and pre-pregnancy weight status.

Preliminary results

Nine hundred seventy-seven women (78%) completed the LEAP survey and 656 reported a live birth. Of these, 379 (58%) agreed to release medical records, and 250 records were abstracted (66% of the 379). Of the 977 survey respondents 769 (79%) reported attempting a pregnancy, and 656 (67%) reported at least one live birth. The validation subsample was similar to the overall cohort. Women with a high GWG had a higher adolescent BMI percentile and prevalence of unhealthy weight control behaviors than those with moderate or low GWG.

Conclusions

LEAP offers a valuable resource for identifying life course factors that may influence the health of pregnant people and their offspring.
Musculoskeletal pain affects the age of retirement and the risk of work cessation among older people
Authors: Niederstrasser Nils Georg , Wainwright Elaine , Stevens Martin J.
Published: March 2024

Objectives

Many people with chronic pain cannot work, while working despite chronic pain is linked to absenteeism and presenteeism and a host of other deleterious effects. This disproportionately affects older adults, who are closer to retirement, while the exact relationship between pain and work cessation as well as retirement among older adults is not known. We explore longitudinally the relationship between chronic pain and the risk of ceasing work and entering retirement.

Methods

Data from 1156 individuals 50 years or older living in England taking part in the English Longitudinal Study of Ageing were used in this study. Cox proportional hazards regression analyses were used to examine the nature of the relationship between musculoskeletal pain and work cessation as well as retirement longitudinally over the course of fourteen years.

Results

Suffering from frequent musculoskeletal pain was associated with an increased risk of ceasing work and retiring at an earlier age, as did work dissatisfaction, higher perceived social status, female gender, and not receiving the recognition they felt they deserved in their job. Severity of depressive symptoms, psychosocial job demands, decision authority, and social support did not influence the age at which participants reported work cessation or retirement.

Conclusions

Frequent musculoskeletal pain may increase the risk of earlier work exit and earlier retirement. Further research should establish the mechanisms and decision making involved in leaving the workforce in people with frequent musculoskeletal pain.
Accurate and reproducible enumeration of CD4 T cell counts and Hemoglobin levels using a point of care system: Comparison with conventional laboratory based testing systems in a clinical reference laboratory in Cameroon
Authors: Sagnia Bertrand , Mbakop Ghomsi Fabrice , Moudourou Sylvie , Gutierez Ana , Tchadji Jules , Sosso Samuel Martin , Ndjolo Alexis , Colizzi Vittorio
Published: March 2024

Background

Measurements of CD4 T cells and hemoglobin (Hb) are conventionally used to determine the immunological state and disease progression for HIV-infected patients. We obtained a small lightweight point-of-care device, the BD FACSPrestoTM in order to demonstrate its ability to deliver CD4 and Hb analysis in comparison with two larger clinical machines the BDFACSCantoTM analyzer and Sysmex XN 1000 haematology analyzer. The advantages of using the POC device include access to HIV patient data in remote and in resource limited settings.

Method

The analytical performance of the BD FACSPrestoTM, compared with the FACSCantoTM II flow cytometer and the Sysmex XN 1000 haematology analyzer was evaluated by testing 241 routine clinical specimens collected in EDTA tubes from patients attending the Immunology and Microbiology laboratory of Chantal BIYA International Reference Centre (Yaounde, Cameroon) between January and May 2016.

Results

The mean in absolute counts and percentage of CD4 T cells was 606 cells/mL and 25% respectively via the FACSPrestoTM, and 574 cells/mL and 24% respectively via the BD FACSCantoTM II. The mean concentration of Hb levels was 11.90 on the Sysmex XN 1000 and 11.45 via the BD FACSPrestoTM, A high correlation (R2 = 0.95, P < 0.001) of Hb level measurements was noted between the BD FACSPrestoTM and Sysmex XN 1000 hematology analyzer. Overall, a Bland-Altman plot of the differences between the two methods showed an excellent agreement for absolute and percentage CD4 counts and hemoglobin measurements between POC and conventional methods evaluated here. Furthermore, the study demonstrated the ease of use of the BD FACSPrestoTM POC technology in remote areas.

Conclusion

The BD FACPrestoTM is a suitable tool for CD4 enumeration in resource-limited settings, specifically providing a deployable, reliable POC testing option. The BD FACSPrestoTM performed appropriately in comparison to the conventional reference standard technologies. The BD FACSPrestoTM, system provides accurate, reliable, precise CD4/%CD4/Hb results on venous blood sampling. The data showed good agreement between the BD FACSPrestoTM, BD FACSCantoTM II and Sysmex XN 1000 XN 1000 systems.
Rotation of the Fla2 flagella of Cereibacter sphaeroides requires the periplasmic proteins MotK and MotE that interact with the flagellar stator protein MotB2
Authors: Vélez-González Fernanda , Marcos-Vilchis Arely , Vega-Baray Benjamín , Dreyfus Georges , Poggio Sebastian , Camarena Laura
Published: March 2024

The bacterial flagellum is a complex structure formed by more than 25 different proteins, this appendage comprises three conserved structures: the basal body, the hook and filament. The basal body, embedded in the cell envelope, is the most complex structure and houses the export apparatus and the motor. In situ images of the flagellar motor in different species have revealed a huge diversity of structures that surround the well-conserved periplasmic components of the basal body. The identity of the proteins that form these novel structures in many cases has been elucidated genetically and biochemically, but in others they remain to be identified or characterized. In this work, we report that in the alpha proteobacteria Cereibacter sphaeroides the novel protein MotK along with MotE are essential for flagellar rotation. We show evidence that these periplasmic proteins interact with each other and with MotB2. Moreover, these proteins localize to the flagellated pole and MotK localization is dependent on MotB2 and MotA2. These results together suggest that the role of MotK and MotE is to activate or recruit the flagellar stators to the flagellar structure.
Elzaki residual power series method to solve fractional diffusion equation
Authors: Pant Rajendra , Arora Geeta , Emadifar Homan
Published: March 2024

The time-fractional order differential equations are used in many different contexts to analyse the integrated scientific phenomenon. Hence these equations are the point of interest of the researchers. In this work, the diffusion equation for a one-dimensional time-fractional order is solved using a combination of residual power series method with Elzaki transforms. The residual power series approach is a useful technique for finding approximate analytical solutions of fractional differential equations that needs the residual function’s (n-1)α derivative. Since it is challenging to determine a function’s fractional-order derivative, the traditional residual power series method’s application is somewhat constrained. The Elzaki transform with residual power series method is an attempt to get over the limitations of the residual power series method. The obtained numerical solutions are compared with the exact solution of this equation to discuss the method’s applicability and efficiency. The results are also graphically displayed to show how the fractional derivative influences the behaviour of the solutions to the suggested method.
When local governments’ stay-at-home orders meet the white house’s “opening up america again”
Authors: Mousavi Reza , Gu Bin
Published: March 2024

In the current polarized political climate, citizens frequently face conflicting directives from their local and federal government officials. For instance, on April 16th, 2020, The White House launched the “Opening up America Again” (OuAA) campaign while many U.S. counties had stay-at-home orders. We created a panel data set of U.S. counties to study the impact of U.S. counties’ stay-at-home orders on community mobility before and after The White House’s campaign to reopen the country. Our results suggest that before the OuAA campaign, stay-at-home orders substantially decreased the time spent in retail and recreation businesses. However, after the launch of the OuAA campaign, the time spent at retail and recreational businesses in a typical conservative county increased significantly more than in liberal counties (23% increase in a typical conservative county vs. 9% increase in a typical liberal county). We also found that in conservative counties with stay-at-home orders, time spent at retail and recreational businesses increased less than in those without stay-at-home orders. These findings illuminate that when federal and local government policies are at odds, residents decide which policies to adhere to based on the alignment between their political ideology and the government body. Our findings highlight the substantial importance of each government body in forming citizens’ behaviors, offering practical implications for policy makers during natural disasters.
Description of Saprolegnia velencensis sp. n. (Oomycota), a novel water mold species from Lake Velence, Hungary
Authors: Verebélyi Viktória , Erdei Noémi , Hardy Tímea , Eszterbauer Edit
Published: March 2024

Here, we describe a novel water mold species, Saprolegnia velencensis sp. n. from Lake Velence, in Hungary. Two strains (SAP239 and SAP241) were isolated from lake water, and characterized using morphological and molecular markers. In addition, phylogenetic analyses based on ITS–rDNA regions and on the RNA polymerase II B subunit (RPB2) gene complemented the study. The ITS–rDNA of the two strains was 100% identical, showed the highest similarity to that of S. ferax (with 94.4% identity), and they formed a separate cluster in both the ITS–rDNA and RPB2-based maximum likelihood phylogenetic trees with high bootstrap support. Although mature oogonia and antheridia were not seen under in vitro conditions, the S. velencensis sp. n. could be clearly distinguished from its closest relative, S. ferax, by the length and width of sporangia, as the new species had shorter and narrower sporangia (163.33±70.07 and 36.69±8.27 μm, respectively) than those of S. ferax. The two species also differed in the size of the secondary cysts (11.63±1.77 μm), which were slightly smaller in S. ferax. Our results showed that S. velencensis sp. n. could not be identified with any of the previously described water mold species, justifying its description as a new species.
Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study
Authors: Chang Aileen Y. , Tritsch Sarah R. , Herrera Gomez Carlos Andres , Encinales Liliana , Cadena Bonfanti Andres , Rosales Wendy , Mendoza-Torres Evelyn , Simmens Samuel , Amdur Richard L. , Mores Christopher N. , Fierbaugh Paige , Perez Hernandez Carlos Alberto , Avendaño Geraldine , Silvera Paula Bruges , Crespo Yerlenis Galvis , Jimenez Alberto David Cabana , Martinez Zapata Jennifer Carolina , Jimenez Dennys , Osorio-Llanes Estefanie , Castellar-Lopez Jairo , Suchowiecki Karol , Martins Karen , Gregory Melissa , Zuluaga Ivan , Proctor Abigale , Hernández Alfonso Sucerquia , Sierra-Carrero Leandro , Colpas Maria Villanueva , Hernandez Juan Carlos Perez , Quast Andres Alberto Figueroa , De Barros Joaquin Andres Calderon , Mejía José Forero , Ruiz Johan Penagos , Boyle David , Firestein Gary S. , Simon Gary L.
Published: March 2024

Objective

To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.

Methods

Participants with chikungunya arthritis were recruited from Colombia from 2019–2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay. Peripheral blood T cell subsets were measured using flow cytometry.

Results

Among participants with chikungunya arthritis (N = 158), IL-2 levels and frequency of regulatory T cells (Tregs) were low. Increased arthritis disease activity was associated with higher levels of inflammatory cytokines (IL-6, TNF and CRP) and immunoregulatory cytokine IL-10 (p<0.05). Increased arthritis flare activity was associated with higher Treg frequencies (p<0.05) without affecting T effector (Teff) frequencies, Treg/Teff ratios and Treg subsets. Finally, elevated levels of IL-2 were correlated with increased Treg frequency, percent Tregs out of CD4+ T cells, and Treg subsets expressing immunosuppressive markers, while also correlating with an increased percent Teff out of live lymphocytes (p<0.05).

Conclusion

Chikungunya arthritis is characterized by increased inflammatory cytokines and deficient IL-2 and Treg responses. Greater levels of IL-2 were associated with improved Treg numbers and immunosuppressive markers. Future research may consider targeting these pathways for therapy.
How does a motor or cognitive dual-task affect our sense of upper limb proprioception?
Authors: Ager Amanda L. , Cools Ann M. , Borms Dorien , Roy Jean-Sébastien
Published: March 2024

Background

Daily upper limb activities require multitasking and our division of attention. How we allocate our attention can be studied using dual-task interference (DTi). Given the vital role proprioception plays in movement planning and motor control, it is important to investigate how conscious upper limb proprioception is impacted by DTi through cognitive and motor interference.

Purpose

To examine how dual-task interference impacts conscious upper limb proprioception during active joint repositioning tasks (AJRT).

Methods

Forty-two healthy participants, aged between 18 and 35, took part in this cross-sectional study. Participants completed two AJRT during three conditions: baseline (single task), dual-cognitive task (serial subtractions), and dual-motor task (non-dominant hand movements). The proprioceptive error (PE; difference between their estimation and targeted position) was measured using an AJRT of 75% and 90% of maximum internal rotation using the Biodex System IIITM and the Upper Limb Proprioception Reaching Test (PRO-Reach). To determine if PEs differed during dual-task interference, interference change scores from baseline were used with one sample t-tests and analyses of variance.

Results

The overall mean PE with the Biodex was 4.1° ± 1.9 at baseline. Mean change scores from baseline reflect a mean improvement of 1.5° ± 1.0 (p < .001) during dual-cognitive task and of 1.5° ± 1.2 (p < .001) during dual-motor task. The overall mean PE with the PRO-Reach was 4.4cm ± 1.1 at baseline. Mean change scores from baseline reflect a mean worsening of 1.0cm ± 1.1 (p < .001) during dual-cognitive task and improvement of 0.8cm ± 0.6 (p < .001) during dual-motor task. Analysis of variance with the Biodex PEs revealed an interference effect (p < .001), with the cognitive condition causing greater PEs compared to the motor condition and a criterion position effect (p = .006), where 75% of maximum IR produced larger PEs during both interference conditions. An interference effect (p = .022) with the PRO-Reach PEs was found highlighting a difference between the cognitive and motor conditions, with decreased PEs during the contralateral motor task.

Conclusion

Interference tasks did impact proprioception. Cognitive interference produced mixed results, whereas improved proprioception was seen during motor interference. Individual task prioritization strategies are possible, where each person may choose their own attention strategy when faced with dual-task interference.
Moonlight-driven biological choruses in Hawaiian coral reefs
Authors: Duane Daniel , Freeman Simon , Freeman Lauren
Published: March 2024

Sounds from fish and invertebrates in coral reefs can create persistent cacophonies that can be recorded for ecosystem monitoring, including during nighttime hours where visual surveys are typically not feasible. Here we use soundscape measurements in Hawaii to demonstrate that multiple coral reef communities are rapidly responsive to shifts in nighttime ambient light, with sustained changes in biological sound between moonrise and moonset. High frequency pulse train sounds from fish (0.5-1.5 kHz) are found to increase during moonlight hours, while low frequency fish vocalizations (0.1-0.3 kHz) and invertebrate sounds (2-20 kHz) are found to decrease during moonlight hours. These discoveries suggest that the rising and setting of the moon triggers regular shifts in coral reef ecosystem interactions. Future acoustic monitoring of reef health may be improved by comparing soundscapes during moonlight and non-moonlight hours, which may provide early indicators of shifts in the relative abundance of separate reef communities.
Association of antihypertensives and Parkinson’s disease in a primary care population matched for underlying diagnosis
Authors: Schrag Anette , Kostev Karel
Published: March 2024

Purpose

To examine the association of several antihypertensive medication classes with incidence of Parkinson’s disease (PD), taking into account possible underlying conditions.

Methods

In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatment indications associations with different antihypertensive medication groups, including diuretics, betablockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin-II receptor-blockers and PD were examined.

Results

Antihypertensive medications overall were associated with a lower risk of subsequent diagnosis of PD (OR: 0.94, 95% CI 0.90–0.97), with the negative association most significant for medications acting on the renin–angiotensin–aldosterone system. A positive association with diagnosis of PD was only seen for betablockers and restricted to those with relatively young age and not in those with longer treatment duration.

Conclusion

When taking into account underlying diagnoses, antihypertensive medications overall were associated with a reduced incidence of PD.
Antihypertensive medication persistence and adherence among non-Hispanic Asian US patients with hypertension and fee-for-service Medicare health insurance
Authors: Choi Eunhee , Mizuno Hiroyuki , Wang Zhixin , Fang Chloe , Mefford Matthew T. , Reynolds Kristi , Ghazi Lama , Shimbo Daichi , Muntner Paul
Published: March 2024

Background

Less than 50% of non-Hispanic Asian adults taking antihypertensive medication have controlled blood pressure.

Methods

We compared non-persistence and low adherence to antihypertensive medication between non-Hispanic Asian and other race/ethnicity groups among US adults ≥66 years who initiated antihypertensive medication between 2011 and 2018 using a 5% random sample of Medicare beneficiaries (non-Hispanic Asian, n = 2,260; non-Hispanic White, n = 56,000; non-Hispanic Black, n = 5,792; Hispanic, n = 4,212; and Other, n = 1,423). Non-persistence was defined as not having antihypertensive medication available to take in the last 90 of 365 days following treatment initiation. Low adherence was defined as having antihypertensive medication available to take on <80% of the 365 days following initiation.

Results

In 2011–2012, 2013–2014, 2015–2016 and 2017–2018, the proportion of non-Hispanic Asian Medicare beneficiaries with non-persistence was 29.1%, 25.6%, 25.4% and 26.7% (p-trend = 0.381), respectively, and the proportion with low adherence was 58.1%, 54.2%, 53.4% and 51.6%, respectively (p-trend = 0.020). In 2017–2018, compared with non-Hispanic Asian beneficiaries, non-persistence was less common among non-Hispanic White beneficiaries (risk ratio 0.74 [95%CI, 0.64–0.85]), non-Hispanic Black beneficiaries (0.80 [95%CI 0.68–0.94]) and those reporting Other race/ethnicity (0.68 [95%CI, 0.54–0.85]) but not among Hispanic beneficiaries (1.04 [95%CI, 0.88–1.23]). Compared to non-Hispanic Asian beneficiaries, non-Hispanic White beneficiaries and beneficiaries reporting Other race/ethnicity were less likely to have low adherence to antihypertensive medication (relative risk 0.78 [95%CI 0.72–0.84] and 0.84 [95%CI 0.74–0.95], respectively); there was no association for non-Hispanic Black or Hispanic beneficiaries.

Conclusions

Non-persistence and low adherence to antihypertensive medication were more common among older non-Hispanic Asian than non-Hispanic White adults.
Association between smoking and lack of HIV virological suppression in a cross-sectional study of persons with HIV on antiretroviral therapy in Uganda
Authors: Tumwegamire Adah , Fatch Robin , Emenyonu Nneka I. , Lodi Sara , Muyindike Winnie R. , Kekibiina Allen , Adong Julian , Ngabirano Christine , Beesiga Brian , Marson Kara , Golabi Nakisa , Kamya Moses , Chamie Gabriel , Hahn Judith A.
Published: March 2024

Background

Smoking and alcohol use frequently co-occur and are the leading causes of preventable death in sub-Saharan Africa (SSA) and are common among people living with HIV (PLWH). While alcohol use has been shown to be associated with reduced adherence to antiretroviral treatment (ART), which may affect HIV viral suppression, the independent effect of smoking on HIV outcomes in SSA is unknown. We aimed to 1) describe the prevalence of current smoking and correlates of smoking; 2) assess the association of smoking with viral suppression, adjusting for level of alcohol use; 3) explore the relationship between smoking and CD4 cell count <350 cells/mm3, among participants who are virally suppressed.

Methods

We analyzed data from the Drinkers Intervention to Prevent Tuberculosis (DIPT) and the Alcohol Drinkers’ Exposure to Preventive Therapy for TB (ADEPTT) studies conducted in Southwest Uganda. The studies enrolled PLWH who were on ART for at least 6 months and co-infected with latent tuberculosis and dominated with participants who had unhealthy alcohol use. Current smoking (prior 3 months) was assessed by self-report. Alcohol use was assessed using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C, modified for prior 3 months) and phosphatidylethanol (PEth), an alcohol biomarker. We used logistic regression to estimate the cross-sectional association between smoking and lack of virological suppression (≥40 copies/ml), adjusting for level of alcohol use and other covariates, and to examine the association between smoking and CD4 cell counts among PLWH with viral suppression.

Results

Of the 955 participants enrolled from 2017 to 2021 who had viral load (VL) results, 63% were men, median age was 40 years (interquartile range [IQR] 32–47), 63% engaged in high/very high-risk alcohol use (AUDIT-C≥6 or PEth≥200 ng/mL), and 22% reported smoking in the prior 3 months. Among 865 participants (91%) with viral suppression and available CD4 count, 11% had a CD4 cell count <350 cells/mm3. In unadjusted and adjusted analyses, there was no evidence of an association between smoking and lack of virological suppression nor between smoking and CD4 count among those with viral suppression.

Conclusions

The prevalence of smoking was high among a study sample of PLWH in HIV care with latent TB in Southwest Uganda in which the majority of persons engaged in alcohol use. Although there was no evidence of an association between smoking and lack of virological suppression, the co-occurrence of smoking among PLWH who use alcohol underscores the need for targeted and integrated approaches to reduce their co-existence and improve health.
Healthcare resource utilization and associated costs among patients with migraine in Finland: A retrospective register-based study
Authors: Kosunen Mikko , Rossi Jari , Niskanen Severi , Metsä Roope , Kainu Ville , Lahelma Mari , Isomeri Outi
Published: March 2024

Migraine is a common chronic brain disorder, characterized by recurring and often disabling attacks of severe headache, with additional symptoms such as photophobia, phonophobia and nausea. Migraine affects especially the working age population. The objective of this retrospective observational register-based study was to analyze the use of healthcare services and associated costs in Finnish migraine patients. Study was based on aggregate data from January 1st, 2020, to December 31st, 2021, from the Finnish Institute for Health and Welfare’s national registries. Patients were grouped into nine patient groups according to medication prescriptions and diagnoses. Healthcare resource utilization in specialty, primary, and occupational healthcare was assessed and analyzed separately for all-cause and migraine related healthcare contacts from a one-year period. The total number of patients was 175 711, and most (45%) of the patients belonged to a group that had used only one triptan. Migraine related total healthcare resource utilization was greater for patients that had used two or more triptans compared to those that had used only one. The patients with three or more preventive medications had the highest total migraine related healthcare resource utilization of the studied patient cohorts. Of the total annual healthcare costs 11.5% (50.6 million €) was associated to be migraine related costs. Total per patient per year healthcare costs were highest with patients that had used three or more preventive medications (5 626 €) and lowest in those with only one triptan (2 257 €). Our findings are in line with the recent European Headache Federation consensus statement regarding the unmet need in patients who have had inadequate response to two or more triptans. When assessing the patient access and cost-effectiveness of novel treatments for the treatment of migraine within different healthcare systems, a holistic analysis of the current disease burden along with potential gains for patients and healthcare service providers are essential information in guiding decision-making.
Groups of Non-Conventional Means Referring to Time in Literary Texts.
Authors: Spachil Olga
Published: March 2024

The paper is an extensive analysis of literary texts spanning different eras, genres, and languages (including the epic of Gilgamesh, Russian works by A. P. Chekhov, S. Dovlatov, G. G. Demidov, as well as English works by W. Shakespeare, R. P. Warren, W. Faulkner, K. Vonnegut). Through this analysis, the author identified a common poetic feature shared by these works: the utilization of both conventional and non-conventional means to convey the passage of time. The objective of the study was to examine and categorize these non-conventional means according to their respective referential spheres, as well as to elucidate their functions within literary texts. Four main groups were identified, encompassing references to food, human physiology, events or objects in the characters’ living spaces, and processes in nature. The study reveals that non-conventional methods of conveying time in literature are considered archaic; however, they are still widely employed to personalize characters’ perception of time and highlight its psychological aspect. The temporality of these methods is generally reinforced through the use of adverbs, prepositions, or grammatical structures that indicate time. In conclusion, it is established that due to the directional nature of time, its fluidity, and the inevitability of approaching death, authors strive to find ways to capture and define time, giving it tangible forms, and in doing so, the past becomes alive once more.
Means and Functions of Intersemiotics in the Novel Girl with a Pearl Earring by T. Chevalier
Authors: Osadchaya Tatyana
Published: March 2024

The article studies approache to the concept of ‘intersemiotics’ in contemporary literary studies. The author provides its definition and characteristic, defines peculiar features of intersemiotics among other related concepts. The purpose of the study is to identify and analyze means and functions of the category of intersemiotics in the novel Girl with a Pearl Earring by T. Chevalier. The analysis of the novel has shown that the key means for implementing the category of intersemiotics are as follows: ekphrasis, the interaction of different types of iconic signs which creates additional meanings, and lingua‐artistic technique of writing. All of these means are firstly used as one of the author’s tools for embodying the profound meaning of the work, secondly, they contribute to the creation of visual images in the reader’s mind, which, in turn, become the basis for recreating
“Rus', You are but a Kiss in the Cold!” (1921) by V. Khlebnikov: Text as a Combinatory Model / Dynamic Construction
Authors: Tyryshkina Tyryshkina Elena
Published: March 2024

The paper is devoted to analysis of the poem by Velimir Khlebnikov “Rus', you are but a kiss in the frost!” (1921) as part of a study of transformation of the sonnet genre in the poet’s verses. Velimir Khlebnikov elaborates his version of a lyrical story of ‘a kiss in the frost’, originating from the poem by Alexander Pushkin “Winter. What do we do in the village?…” (1829). The love scene is represented as a natural phenomenon, embedded not only in the winter landscape but also in the Universe. There are no persons in the Nature’s integrity, and the couple of lovers are designated only by demonstrative pronouns. The tension of feelings (“the lightning kiss”) is but one of the manifestations of the Elements. The phenomenon of a lightning as a “potentially energy-embracing symbol” has a conceptual character in Khlebnikov’s perception of the world, is both the “primordial image” of the world and the principle of universal unity, which has already been noted by the eminent researchers’ of Khlebnikov’s works. From the formal viewpoint, the text is a special variant of structural deformity and overcoming it, which is directly related to the idea of accumulation of energy, explosion, and return to tranquility. The poem is characterized by increased expression of the arrangement of its sounds; alliteration of the occlusive, fricative, and sonorant sounds, their combinations, and paronymic attraction create the effect of a special energy of sound-making. The rhythmic arrangement of the text “deceives” the reader’s expectations: fast shifts and transitions from one meter to another (polymetry in the first stanza), occasional caesuras in the first, fourth, and ninth verses, an enjambement in the seventh and eighth verses: breakage of the seventh verse, when the verb “would [swiftly] outline” starts a line, visualizing the movement of a lightning. Structural deformities are settled in the final — the last verse is written in a classical iambic tetrameter. Graphically, the lyrical text is a combinatory dynamic model which may vary in terms of strophic division, the “headless” sonnet, preserving the characteristics of the Italian sonnet, dominates. The mechanism of cohesion is ensured by all the levels of the artistic whole, and the genre of the sonnet is a harmonizing form, balancing the structural instability of the text.
Ordinary Semantics of Bionym Voron / Kuskun [Raven] in the Russian and Tuvan Language (Based on a Linguistic Experiment)
Authors: Nurzet Tserinchimed Suge-Baadyrovich
Published: March 2024

The article presents the results of a linguistic experiment aimed at studying the ordinary semantics of voron / kuskun (raven) bionyms in the Russian and the Tuvan languages. The study was conducted within the scope of ethnoconceptology and describes the semantics of lexical units from the point of view of ordinary native speakers. The main methods of the work undertaken were an association experiment consisting of 6 tasks aimed at various layers of semantics, and a comparative method. The experiment made it possible to identify significant concepts in the lexeme. Due to comparison, the universal and nationally specific characteristics of the studied bionyms were revealed. Common and differential features were combined according to various aspects characterizing the bionym. The universal properties of bionyms are determined by the objective properties of the denotation (bird as a categorical feature of the bionym, physical characteristics of the bird, habitat, and habits). The national-specific originality of bionyms is found to a greater extent in precedent texts and is associated with the cultural peculiarities of the semantics of the bionym.
INFLUENCE OF POPULUS BALZAMIFERA BUDNEY EXTRACT ON THE GROWTH AND DEVELOPMENT OF CABBAGE
Authors: Meshchanova Anna Gennadievna , Polyakov Vladilen Vasilievich , Krotova Svetlana Alexandrovna
Published: March 2024

In recent years, there has been a persistent search for new methods and technologies for cultivating individual crops in order to increase their productivity and improve product quality. New methods of pre-sowing seed treatment with biological stimulants are increasingly being introduced, increasing not only crop yields, but also changing (increasingly) the content of important nutrients (proteins, fats, carbohydrates, oils, and others). Despite the rapid development of chemistry and the growth in the number of new highly effective drugs of biotechnological and synthetic origin, plants continue to occupy a significant place as a growth stimulator of agricultural crops.

The aim of the work is to evaluate the effect of poplar extract on the growth and development of white cabbage.

Tasks: to investigate the qualitative composition of the aqueous extract of poplar buds; to establish the growth-stimulating activity of the extract of balsamic poplar buds in relation to the seeds of white cabbage.

Methodology and scientific approaches: in the course of the work, experimental studies were carried out on the extraction of natural compounds of balsam poplar buds, evaluating the effectiveness of the balsam poplar bud extract on the growth and development of white cabbage.

Results and conclusions: in the composition of the aqueous extract of poplar buds, such classes of compounds as flavonoids, tannins, coumarins, saponins, amino acids, phenolic acids, polysaccharides were identified; the use of poplar bud extract had a significant impact on morphogenesis, physiological and biochemical parameters, and the productivity of white cabbage of the "Gift" variety.
OPTIMIZATION OF THE METHOD OF QUANTITATIVE DEFINITIONS OF FLAVONOIDS IN THE RAW MATERIALS OF "MENYANTHIDIS TRIFOLIATAE LEAVES"
Authors: Andreeva Valeria Yurievna , Zinner Nadezhda Sergeevna , Kadyrova Tatyana Vladimirovna , Belousov Mikhail Valerievich
Published: March 2024

The aim of the study is to optimize the methodology of quantitative determination of flavonoids in the leaves of Menyanthidis trifoliatae. In official medicine, the leaves of Menyanthidis trifoliatae are used for anorexia and dyspeptic disorders.

In the current regulatory documentation (State Pharmacopoeia of the Russian Federation), it is proposed to evaluate the quality of raw materials by the content of the amount of flavonoids in terms of rutin using spectrophotometry. This technique is based on the ability of flavonoids containing free aromatic hydroxyl groups to form colored products with diazotized sulfanilic acid. The disadvantage of this technique is the long and time-consuming stage of cleaning raw materials from certain groups of lipophilic substances, which can also react with diazotized sulfanilic acid to form colored products.

We have proposed a selective method for the quantitative determination of flavonoids in the herb trifoliate by the method of spectrophotometry in terms of rutin. The technique is based on the ability of flavonoids to form stable colored complexes with aluminum chloride. We have selected the optimal conditions for extraction and complexation reaction of aluminum chloride with flavonoids of M. trifoliatae extract. The proposed method has been validated and is suitable for use in an analytical laboratory.
Investigating the Correlation between Immune Infiltrate and Treatment Response in Triple Negative Breast Cancer Patients
Authors: Fong Arwen , Hung Jerry , Ewart Grace , Suresha Satvika
Published: March 2024

Triple-negative breast cancers (TNBC) lack progesterone, estrogen, and human epidermal growth factor receptors. Consequently, traditional hormone therapies are ineffective against TNBC resulting in fewer treatment options compared to other types of breast cancer. However, immunotherapy has emerged as an effective treatment for TNBC due to higher expression of PD-L1 and more tumor infiltrating lymphocytes (TILs) in TNBCs compared to other types of breast tumors. Here, we aim to (1) characterize the immune infiltrate of TNBC patient tumor biopsies, and (2) assess how patients respond to immune checkpoint blockade (ICB) therapy based on immune infiltration of tumors. We will collect tumor biopsies from treatment-naive females with TNBC, and conduct imaging mass cytometry to identify infiltrating immune cells, including lymphoid and myeloid lineage cells. Patients will be subject to immune checkpoint blockade therapy and receive monthly checkups, where mammograms will be performed to assess structural changes of the cancer to determine the effectiveness of the treatment over time. We predict the treatment will be more effective in patients with high levels of TILs and myeloid-derivedsuppressor cells (MDSCs). The results of this study may confirm that a higher presence of TILs and MDSCs generally correlates to a better response to ICB therapy.
«Me miras… ¡y puedo!»
Authors: Luján Ocejo Paloma
Published: March 2024

Una mirada de confianza, que dé alas, que capacite para el más alto vuelo, eso es lo que deseamos para nuestros hijos y alumnos, y sabemos que en ocasiones no es fácil, pero siempre merece la pena. Y es esto lo que intentamos llevar a las aulas desde el proyecto Aprendamos a Amar del Instituto Desarrollo y Persona de la UFV, porque la educación afectivo-sexual en la etapa de infantil y primaria comienza con esta mirada de belleza sobre el propio cuerpo sexuado. ¡No tengamos miedo a hablar bien de las cosas buenas!
Codocencia en clave de pedagogía ignaciana
Authors: García Molina Irene
Published: March 2024

La codocencia, cada vez más extendida en la red de centros EDUCSI, quiere ser una respuesta a los retos de la educación hoy. Desde el Colegio San Ignacio de Loyola en Gran Canaria, detectamos la necesidad de generar una dinámica de evaluación y mejora continua que lleve la práctica codocente a su magis. Nuestra propuesta: Codocencia en clave de pedagogía ignaciana, un modelo sustentado en tres pilares y cinco tensiones; con un instrumento, la Rúbrica para la evaluación de la codocencia en clave PI.
A importância da precificação para as micro e pequenas empresas
Authors: Maia Priscila Araujo , Melo Valdir Agustinho , Dias Diego Nonato Bastos
Published: March 2024

As Micro e Pequenas Empresas (MPE) desempenham um papel fundamental na econômia brasileira, contribuindo para a geração de empregos da população, além de promover redução da desigualdade social. Representam cerca de 20% do Produto Interno Bruto (PIB) brasileiro e 60% dos 100 milhões de empregos do país. A precificação para as MPE, na maioria das vezes é o fator determinante para a decisão de compra dos seus produtos e serviços pelos consumidores. Mas, uma precificação errônea pode levar uma MPE ao encerramento das atividades. Portanto, realizou-se um estudo de caso de abordagem quantitativa em uma pequena empresa de comidas congeladas, desenvolvido para compreender os processos de precificação. Primeiramente, se observou os problemas de precificação utilizando os seguintes métodos: Ciclo Plan-Do-Check-Act. 5W2H; Diagrama de Ishikawa e 5 Porquês. Constatou-se que a empresa em estudo não apurava os seus custos de forma correta, mantinha um cardápio com preços defasados, e não apresentava nenhum controle financeiro, logo não tinha a visão real do desempenho do negócio. Através de métodos específicos, da aplicação de ferramentas de suporte ao planejamento financeiro, foi possível formar o preço de venda incluindo todos os custos envolvidos, e apontar algumas alternativas para um aumento de receita.
Proposta de interface do sistema Kanban para gestão de projetos em um setor de teste de software
Authors: Lavareda Adriely de Souza , Silva Ana Paula Moraes e , Lima Júlio Cezar dos Santos , Freires Vitória Vitória de Melo , Veroneze Gabriela de Mattos , Oliveira Marcelo Albuquerque de
Published: March 2024

O artigo descreve o desenvolvimento de uma interface de gestão de projetos para testes de software, com enfoque em aplicação prática, exploração e abordagem qualitativa. A proposta visa implementar um sistema Kanban, amplamente reconhecido na gestão de demandas, para oferecer uma visão clara e intuitiva da alocação de projetos, horas de trabalho por funcionário e indicadores de desempenho da equipe. A abordagem utiliza premissas e técnicas de experiência do usuário, incluindo questionários para requisitos, criação de personas para perfis personalizados e Wireframe para esboços de interfaces. A interface resultante foi submetida a avaliação qualitativa, considerando a experiência do usuário, organização lógica, facilidade de visualização e conforto percebido. Em geral, a proposta foi bem recebida, com a maioria das avaliações expressando receptividade à utilização da interface. Após a implantação da interface de gestão de projetos para testes de software, os usuários destacaram a melhor visibilidade do progresso dos projetos e a transparência na alocação de tarefas. No entanto, foram observados problemas relacionados às cores da interface e ao gráfico de porcentagem de projetos por status, sugerindo a necessidade de ajustes.
SOURCES OF SOCIAL SUPPORT AND RESILIENCE AMONG ADOLESCENTS IN TANGERANG REGENCY
Authors: Puspitaningrum Ni Putu Putri , Pudjiati Sri Redatin Retno
Published: March 2024

Resilience is an important factor that can help a person to get through difficult phases in life. Current research focuses on dynamic resilience, which can be developed through interaction with the surrounding environment. In this study will be further analyzed the effect of each source of perceived social support on adolescent resilience in Tangerang Regency, as one of the areas prone to crime. Participants in this study were 429 junior high school students aged 13-16 years old. The study used The 14-Items Resilience Scale (RS-14) and The Multidimensional Scale of Perceived Social Support (MSPSS) which had previously been adapted by researchers. The results showed that perceived social support was a predictor of adolescent resilience in Tangerang Regency with a medium effect size, R2 = .166, F(1, 427) = 84.861, p = .000. In general, there is no difference between the social support received by male and female adolescents, t(427) = 0.402, p = .689. However, it was found that female adolescents feel more supported by friends compared to male adolescents, t(427) = -3.041, p = .003.
Pablo Picasso: In Search Of Language
Authors: Mallen Enrique
Published: March 2024

The article explores Picasso’s multiple influences early in his career as he searched for a language that best expressed his vision of reality. Already the first critics, such as Félicien Fagus for his first exhibition at Galerie Vollard, mentioned the impact on the young Spaniard of a wide range of modern painters in addition to the great classical masters. Many of the identifiable periods in his extensive career can be associated with one or more influential artists: Casas, Rusiñol, Steinlen, Munch during the Modernist years in Barcelona; Toulouse-Lautrec, Renoir, Degas, Van Gogh and others in the first years in Paris; El Greco, Nonell, Puvis, among others during the Blue Period; Matisse, Redon, and others, in the Rose Period; Gauguin later on, etc., etc. These are just a few of the many artists whose styles Picasso explored in numerous ways. Their influence often occurred in complex combinations and would not fully disappear from his works once their incidence had left their imprint. Thus one can find the presence of El Greco or Van Gogh as late as the last years of Picasso’s life. Here we will focus on their influence in the period that preceded Cubism, Picasso’s first truly original language