bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling, Dynamics, Bifurcation Behavior and Stability Analysis of a DC–DC Boost Converter in Photovoltaic Systems
Authors: Zhioua M. , El Aroudi A. , Belghith S. , Bosque-Moncusí J. M. , Giral R. , Al Hosani K. , Al-Numay M.
Published: September 2016

A study of a DC–DC boost converter fed by a photovoltaic (PV) generator and supplying a constant voltage load is presented. The input port of the converter is controlled using fixed frequency pulse width modulation (PWM) based on the loss-free resistor (LFR) concept whose parameter is selected with the aim to force the PV generator to work at its maximum power point. Under this control strategy, it is shown that the system can exhibit complex nonlinear behaviors for certain ranges of parameter values. First, using the nonlinear models of the converter and the PV source, the dynamics of the system are explored in terms of some of its parameters such as the proportional gain of the controller and the output DC bus voltage. To present a comprehensive approach to the overall system behavior under parameter changes, a series of bifurcation diagrams are computed from the circuit-level switched model and from a simplified model both implemented in PSIM© software showing a remarkable agreement. These diagrams show that the first instability that takes place in the system period-1 orbit when a primary parameter is varied is a smooth period-doubling bifurcation and that the nonlinearity of the PV generator is irrelevant for predicting this phenomenon. Different bifurcation scenarios can take place for the resulting period-2 subharmonic regime depending on a secondary bifurcation parameter. The boundary between the desired period-1 orbit and subharmonic oscillation resulting from period-doubling in the parameter space is obtained by calculating the eigenvalues of the monodromy matrix of the simplified model. The results from this model have been validated with time-domain numerical simulation using the circuit-level switched model and also experimentally from a laboratory prototype. This study can help in selecting the parameter values of the circuit in order to delimit the region of period-1 operation of the converter which is of practical interest in PV systems.
Escape Rates for the Farey Map with Approximated Holes
Authors: Bonanno Claudio , Chouari Imen
Published: September 2016

We study the escape rate for the Farey map, an infinite measure preserving system, with a hole including the indifferent fixed point. Due to the ergodic properties of the map, the standard theoretical approaches to this problem cannot be applied. It has been recently shown in [Knight & Munday, 2016] how to apply the standard analytical methods to a piecewise-linear version of the Farey map with holes depending on the associated partition, but their results cannot be obtained in the general case we consider here. To overcome these difficulties we propose here to study approximations of the hole by means of real analytic functions. We introduce a particular family of approximations and study numerically the behavior of the escape rate for approximated holes with vanishing measure. The results suggest that the scaling of the escape rate depends on the “shape” of the approximation, and we show that this is a typical feature of systems with an indifferent fixed point, not an artifact of the particular family we consider.
Odd Ghrist Templates are Universal
Authors: Hanson Eric J. , LoFaro Thomas
Published: September 2016

In a pair of papers, Robert Ghrist constructed two families of branched two-manifolds, or knot templates, that are universal. That is, each template contains an isotopic copy of every knot (and link) type as a periodic orbit of the corresponding semiflow. A common feature of these families is an even number of half-twists in one of the strips. We eliminate the requirement that the number of half-twists be even and call the enlarged family of templates Ghrist templates. We demonstrate that all Ghrist templates are universal, specifically those containing an odd number of half-twists. We then use this result to briefly examine the knot structure of a geometric model of a system of differential equations on [Formula: see text] known as the Newton–Leipnik equations.
Resonant frequencies of the hydrodynamic vortex
Authors: Vieira H. S.
Published: September 2016

We study the sound perturbation of the hydrodynamic vortex geometry and present an exact expression for the resonant frequencies (quasispectrum) of this geometry. Exact solution for the radial part of the covariant Klein–Gordon equation in this spacetime is obtained, and is given in terms of the double confluent Heun functions. We found that the resonant frequencies are complex number.
Reference Modeling for Data Analysis: The BIRD Approach
Authors: Schuetz Christoph G. , Neumayr Bernd , Schrefl Michael , Neuböck Thomas
Published: September 2016

Reference models for data analysis with data warehouses may consist of multidimensional reference models and analysis graphs. Multidimensional reference models are best-practice domain-specific data models for online analytical processing. Analysis graphs are reference models of analysis processes for event-driven data analysis. Small and medium-sized enterprises (SMEs) as well as large multinational companies may benefit from the use of reference models for data analysis. The availability of multidimensional reference models lowers the obstacles that inhibit SMEs from using business intelligence (BI) technology. Multinational companies may define multidimensional reference models for increased compliance among subsidiaries and departments. Furthermore, the definition of analysis graphs facilitates the handling of business events for both SMEs and large companies. Modelers may customize the chosen reference models, tailoring the models to the specific needs of the individual company or local subsidiary. Customizations may consist of additions, omissions, and modifications with respect to the reference model. In this paper, we propose a metamodel and customization approach for multidimensional reference models and analysis graphs. We specifically address the explicit modeling of key performance indicators as well as the definition of analysis situations and analysis graphs.
A Contextual Evaluation of Composite Forecasts of Annual Earnings
Authors: Elgers Pieter T. , Lo May H. , Xie Wenjuan , Xu Le Emily
Published: September 2016

This study addresses the impact of firm- and time-specific attributes on the accuracy of composite forecasts of annual earnings, constructed from time-series, price-based, and analysts' forecasts. The attributes examined include firm size, analysts' coverage, and time periods pre-dating and following the implementation of regulation fair disclosure. Our results indicate that the relative accuracy of the composite forecasts is time-specific. In the pre-regulation fair disclosure period, composite forecasts significantly outperform each of the three individual forecast sources. Moreover, the extent of improvement in accuracy of composite forecasts is significantly higher for the smaller and lightly-covered firms. Collectively, these results suggest that the predictive accuracy of composite forecasts is contextual.
Heterogeneous Effect of Financial Leverage on Corporate Performance: A Quantile Regression Analysis of Taiwanese Companies
Authors: Ku Yu-Yen , Yen Tze-Yu
Published: September 2016

The effect of financial leverage on corporate performance has been debated. We reexamine the effect by using a sample of 6,630 observations from nonfinancial Taiwanese publicly traded companies during the 2008–2012 period, employing the quantile regression approach and comparing its results with the ones provided by conventional models (least squares and fixed effects). Our empirical results show that the effect of financial leverage on the corporate performance is not homogeneous among various quantile levels: the financial leverage destroys (enhances) companies with low (high) return on equity quantiles. Moreover, the association between leverage and corporate performance is trivial when the mid-range performance quantiles are considered. Our findings are consistent with the results provided by Lee and Li [Lee, BS and M-YL Li (2012). Journal of Banking and Finance, 36, 2157–2173] for U.S. firms. The asymmetric relationship between financial leverage and the corporate performance identified in this study can adequately clarify the debated link between financial leverage and the corporate performance reported in previous empirical studies.
Informal Loans in Russia: Why Not to Borrow from a Bank?
Authors: Semenova Maria , Kulikova Victoria
Published: September 2016

After the 2008 crisis, the Russian consumer loan market shows high growth rates, accompanied by the quality deteriorating even faster. At the same time, a great proportion of households are not attracted by the banks and borrow informally. In this paper, we aim to learn why households refuse to become bank clients, using the data from a 2009–2010 national survey of Russian households. Our results suggest that household's choice of the informal credit market is based not only on credit rationing, but also on a lack of financial literacy, credit discipline and trust in the banking sector as a whole.
Vectorial moments of curves in Euclidean 3-space
Authors: Tunçer Yılmaz
Published: September 2016

In this study, we introduced the vectorial moments as a new curves as [Formula: see text]-dual curve, where [Formula: see text], constructed by the Frenet vectors of a regular curve in Euclidean 3-space and we gave the Frenet apparatus of [Formula: see text]-dual curves and also we applied to helices and curve pairs of constant breadth.
Polymeric phthalocyanine sheets as electrocatalytic electrodes for water-oxidation
Authors: Geis Clemens , Schneider Simon P. , Schlettwein Derck
Published: September 2016

Polymeric copper and cobalt phthalocyanine (Cu-pPc and Co-pPc) were prepared as thin films on fluorine-doped tin oxide (FTO) glass from evaporated metal films via a chemical vapor deposition (CVD) process with 1,2,4,5-tetracyanobenzene (TCB). The films were characterized by optical absorption spectroscopy in transmission and by X-ray photoelectron spectroscopy. Different oxidation states of the metal atoms were detected indicating different chemical environments. Reversible electrochemical reduction of Cu-pPc and Co-pPc was observed and monitored by cyclic voltammetry and spectroelectrochemical investigations. Cyclic voltammetry and chronoamperometry in the positive voltage range led to anodic currents in the oxygen evolution reaction that could be performed at stable current densities and showed a remarkable efficiency in particular for electrodes of Co-pPc in this reaction, attractive for the conversion of electrical energy into chemical energy.
Photocatalytic degradation of persistent organic pollutants under visible irradiation by TiO2catalysts sensitized with Zn(II) and Co(II) tetracarboxy-phthalocyanines
Authors: Mahmiani Yaghub , Sevim Altuğ Mert , Gül Ahmet
Published: September 2016

Photo-excitation under visible light has been an important step to acquire solar-driven TiO2photocatalysts and dye sensitization has been used frequently to extend the optical response of TiO2into the visible region. In the present work, new heterogeneous photocatalysts were prepared by anchoring carboxylic acid substituted Zn(II) and Co(II) phthalocyanines onto polycrystalline TiO2surface and their photocatalytic activities were investigated. Due to covalent bonding of carboxy-terminated molecules onto TiO[Formula: see text]semiconductors, we synthesized symmetric 4-hydroxybenzoic acid-bearing metallophthalocyanines as dye sensitizer molecules. Heterogeneous composites having titanium dioxide and metallophthalocyanines anchored via CO–O–TiO2bonds were characterized by using X-ray diffraction (XRD), Fourier-transform infrared spectrometry (FT-IR), and ultraviolet-visible diffuse reflectance spectroscopy. The optimum loading value of the dyes on TiO2were 0.98 [Formula: see text]mol/g TiO2for CoPc and 0.86 [Formula: see text]mol/g TiO2for ZnPc, nearly independent of the amount of TiO2used. These newly obtained heterogeneous photocatalysts were employed in the photocatalytic degradation of 4-chlorophenol(4-CP), chlorobenzene(CB) and 1,2,4-trichlorobenzen(TCB) in aqueous media under visible irradiation. Gas chromatography-mass spectrometry (GC-MS) was used for quantitation. The new photocatalysts showed excellent activities with visible-region irradiation in the photocatalytic degradation of persistent organic pollutants (POPs) as compared to the control experiments used with untreated TiO2and the difference was attributed to the cooperation of the two elements, namely TiO2and MPc. Experiments show that in two hours nearly complete degradation of POPs were observed.
Stochastic hygro-thermo-mechanically induced nonlinear static analysis of piezoelectric elastically support sandwich plate using secant function based shear deformation theory (SFSDT)
Authors: Lal Achchhe , Kulkarni Nikhil M. , Siddaramaiah Vijayakumari H.
Published: September 2016

The second order statistics of transverse nonlinear central deflection of elastically supported piezoelectric laminated composite sandwich plate (ESPLCSP) subjected to hygro-thermo-mechanical loading using micromechanical approach is evaluated in this paper. System randomness as micro-level material properties of fiber and matrix, material properties of piezoelectric, laminate thickness, lamination angle, foundation parameters, and load intensity are taken as independent random variables. The mechanical loading is taken as uniformly distributed and sinusoidal loadings. The secant function based shear deformation theory (SFSDT) with von-Karman nonlinearity is used for basic formulation. The elastic and hygrothermal properties of the composite material are considered to be dependent on temperature and moisture concentration have been evaluated utilized micromechanical modeling. A Newton–Raphson method based on [Formula: see text] nonlinear finite element method combined with mean centered second order perturbation technique (SOPT) proposed by present authors for the composite plate is extended for sandwich composite plate. The effect of random system properties with changing the plate geometry, stacking sequences, support conditions, foundation parameters, piezoelectric layers, fiber volume fraction and temperature, and moisture distribution on ESPLCSP is presented. The performance of proposed approach is validated through comparison with those available in the literature and independent Monte Carlo simulation (MCS).
Energy wave propogation in pristine and bi-crystal graphene
Authors: Wang Ying , Xu Shuai , Liu Zishun , Ng Teng Yong
Published: September 2016

This study investigates the distribution and propagation of potential energy in graphene under tearing loads. Before crack extension, high potential energy accumulates at the crack tip. The distributions of the high potential energy are symmetrical and asymmetrical in pristine graphene and bi-crystal graphene with misorientation angle of [Formula: see text], respectively. When a C–C bond breaks during the fracture of graphene, numerous energy waves successively arise from the crack tip, i.e., the two atoms linked by the broken bond. These atoms lose one bond constraint and turn into unstable states, and they displace with high accelerations. In pristine graphene, the energy waves present as hexagonal geometries, while the waveforms near the loading areas are compressed to flatter geometries. In bi-crystal graphene, the refractions of potential energy waves are observed when the energy waves propagate to the grain boundary (GB) and interact with it, and the waveforms are changed after the wave crosses the GB. For both pristine graphene and bi-crystal graphene, wrinkles are generated when the crack tip extends to the site sufficiently close to the vertical free boundary, and the wrinkles are always nearly parallel to the horizontal free boundary and move along with the motion of the crack tip.
Internal structure and emplacement mechanism of composite plutons: evidence from Mt Kinabalu, Borneo
Authors: Burton-Johnson Alex , Macpherson Colin G. , Hall Robert
Published: September 2016

The internal structure and emplacement mechanisms of composite plutons are investigated using new field data from the composite Late Miocene granitic intrusion of Mt Kinabalu in northern Borneo. The pluton was emplaced in the upper to middle crust in the Late Miocene at the contact between the ultramafic basement and sedimentary cover rocks. Structural data indicate that emplacement occurred during regional NNW–SSE-oriented extension, challenging tectonic models that involve contemporaneous regional compression. The six major units forming the pluton were accommodated by upward flexure of the cover rocks with most magma pulses emplaced successively beneath their predecessors. However, the irregular 3D internal structure of the pluton also reflects preferential emplacement of successive units along the granite–country rock contact of previous units in preference to the basement–cover rock contact exploited by the initial units. This study highlights the complex emplacement mechanisms and internal structure of composite intrusions and assesses how they differ from models of tabular emplacement.
Identification of mantle peridotite as a possible Iapetan ophiolite sliver in south Shetland, Scottish Caledonides
Authors: Day James M. D. , O'Driscoll Brian , Strachan Rob A. , Daly J. Stephen , Walker Richard J.
Published: September 2016

The Neoproterozoic Dunrossness Spilite Subgroup of south Shetland, Scotland, has been interpreted as a series of komatiitic and mafic lava flows formed in a marginal basin in response to Laurentian continental margin rifting. We show that ultramafic rocks previously identified as komatiites are depleted mantle peridotites that experienced seafloor hydrothermal alteration. The presence of positive Bouguer gravity and aeromagnetic anomalies extending from the Dunrossness Spilite Subgroup northward to the Shetland Ophiolite Complex suggests instead that these rocks may form part of an extensive ophiolite sliver, obducted during Iapetus Ocean closure in a forearc setting.

Supplementary material
: Supplementary information, including methods, supplementary figures and tabulated data, is available at
https://doi.org/10.6084/m9.figshare.c.3469161
.
Geochemical characterization and petrogenesis of mafic granulites from the Central Indian Tectonic Zone (CITZ)
Authors: Alam Meraj , Choudhary A. K. , Mouri Hassina , Ahmad Talat
Published: September 2016

A mafic magmatic sequence of the Bhandara–Balaghat Granulite (BBG) Belt is represented by gabbroic rocks containing orthopyroxene (Opx)–clinopyroxene (Cpx)–plagioclase (Pl)–hornblende±quartz±garnet and showing tholeiitic affinity. These rocks are divided into two groups: (I) garnet-bearing; and (II) garnet-free. The garnet-bearing group is characterized by nearly flat REE patterns. In the multi-element plots, Sr, Zr and Ti show negative anomalies, indicating plagioclase, Ti-magnetite and apatite fractionation. The garnet-free rocks are geochemically subdivided into two subgroups: IIa and IIb. Subgroup IIa is marked by flat REE patterns; the LREE shows 20–30 times chondrite abundances and small positive Eu anomalies. Multi-element patterns show negative anomalies of Nb, P and Ti. Subgroup IIb is characterized by slightly enriched patterns; the LREE shows 10–60 times chondrite abundances. The REE patterns for the Subgroup IIb show moderately to highly fractionated LREE with flat HREE. Multi-element plots show negative anomalies in Nb, Ti and Zr. The Nd–Ce relationship suggests that mafic granulites of the BBGs are derived from higher degrees (Group I,
c.
15–30%; Subgroup IIa,
c.
20–40%; and Subgroup IIb,
c.
18–35%) of partial melting of variably enriched mantle sources, followed by the evolution of the parental melt by fractional crystallization of Opx–Cpx–Pl. The geochemical signatures also suggest that the magma was further modified by crustal contamination during the course of its evolution. The Nd (
T
DM
) model ages, which vary from 3.2 to 1.6 Ga, suggest a long-term evolution of the mafic granulites, possibly starting with overprinting of the isotope composition of their mantle source by crustal isotope signatures as a consequence of crustal recycling; evolving by emplacement and crystallization of the protolith at 2.7 Ga, as well as through later tectonotermal events up to granulite-facies metamorphism and exhumation of the BBG Belt during the collision of the Archaean Bundelkhand and Bastar cratons, and the formation of the Central Indian Tectonic Zone (CITZ) at 1.5 Ga.
Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis
Authors: Soria Rodrigo , Egger Matthias , Scherrer Urs , Bender Nicole , Rimoldi Stefano F.
Published: September 2016

More than 140 million people are living at high altitude worldwide. An increase of pulmonary artery pressure (PAP) is a hallmark of high-altitude exposure and, if pronounced, may be associated with important morbidity and mortality. Surprisingly, there is little information on the usual PAP in high-altitude populations. We, therefore, conducted a systematic review (MEDLINE and EMBASE) and meta-analysis of studies published (in English or Spanish) between 2000 and 2015 on echocardiographic estimations of PAP and measurements of arterial oxygen saturation in apparently healthy participants from general populations of high-altitude dwellers (>2,500 m). For comparison, we similarly analyzed data published on these variables during the same period for populations living at low altitude. Twelve high-altitude studies comprising 834 participants and 18 low-altitude studies (710 participants) fulfilled the inclusion criteria. All but one high-altitude studies were performed between 3,600 and 4,350 m. The combined mean systolic PAP (right ventricular-to-right atrial pressure gradient) at high altitude [25.3 mmHg, 95% confidence interval (CI) 24.0, 26.7], as expected was significantly (P < 0.001) higher than at low altitude (18.4 mmHg, 95% CI 17.1,19.7), and arterial oxygen saturation was significantly lower (90.4%, 95% CI 89.3, 91.5) than at low altitude (98.1%; 95% CI 97.7, 98.4). These findings indicate that at an altitude where the very large majority of high-altitude populations are living, pulmonary hypertension appears to be rare. The reference values and distributions for PAP and arterial oxygen saturation in apparently healthy high-altitude dwellers provided by this meta-analysis will be useful to future studies on the adjustments to high altitude in humans.
Case Studies in Physiology: Ventilation and perfusion in a giraffe–does size matter?
Authors: Nyman Görel , Röken Bengt , Hedin Eva-Maria , Hedenstierna Göran
Published: September 2016

The trachea in the giraffe is long but narrow, and dead space ventilation is considered to be of approximately the same size as in other mammals. Less is known about the matching between ventilation and lung blood flow. The lungs in the giraffe are large, up to 1 m high and 0.7 m wide, and this may cause considerable ventilation/perfusion (VA/Q) mismatch due to the influence of gravitational forces, which could lead to hypoxemia. We studied a young giraffe under anesthesia using the multiple inert gas elimination technique to analyze the VA/Q distribution and arterial oxygenation and compared the results with those obtained in other species of different sizes, including humans. VA/Q distribution was broad but unimodal, and the shunt of blood flow through nonventilated lung regions was essentially absent, suggesting no lung collapse. The VA/Q match was as good as in the similarly sized horse and was even comparable to that in smaller sized animals, including rabbit and rat. The match was also similar to that in anesthetized humans. Arterial oxygenation was essentially similar in all studied species. The findings suggest that the efficiency of VA/Q matching is independent of lung size in the studied mammals that vary in weight from less than 1 to more than 400 kg.
Grape Seed Procyanidin Extract Mediates Antineoplastic Effects against Lung Cancer via Modulations of Prostacyclin and 15-HETE Eicosanoid Pathways
Authors: Mao Jenny T. , Smoake Jane , Park Heesung K. , Lu Qing-Yi , Xue Bingye
Published: September 2016

Grape seed procyanidin extract (GSE) has been reported to exert antineoplastic properties via the inhibition of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) eicosanoid pathways. In addition, ample data link carcinogenesis to inflammatory events involving other major eicosanoid metabolic pathways, including prostacyclin (PGI2) and 15-hydroxyeicosatetraenoic acid (15-HETE). We therefore evaluated the effects of GSE on prostacyclin synthase (PTGIS)/PGI2 and 15-lipoxigenase-2 (15-LOX-2)/15-HETE productions by human lung premalignant and malignant cells and correlated the findings with antiproliferative or proapoptotic effects of GSE. The effects of GSE on PGI2 and 15-HETE productions by human bronchoalveolar lavage (BAL) cells ex vivo were also determined. We further evaluated the bioactivity of oral administration of leucoselect phytosome (a standardized GSE) in the lungs of subjects participating in a lung cancer chemoprevention trial, by comparing the antiproliferative effects of coculturing matched pre- versus posttreatment BAL fluids with lung premalignant and malignant cells. GSE significantly increased PGI2 (as measured by 6-keto PGF1α) and 15-HETE productions by these cells. Transfections of PTGIS or 15-LOX-2–specific siRNA partially abrogated the antiproliferative or proapoptotic effects of GSE in lung premalignant and malignant cells, respectively. GSE also increased PTGIS and inhibition of caspase-3, and transfection of 15-LOX-2 siRNA abrogated the GSE-induced apoptosis in A549 cells. In addition, culture supernatants from ex vivo GSE-treated baseline BAL cells, as well as BAL fluids from subjects treated with leucoselect phytosome, significantly decreased proliferations of lung premalignant and malignant cells. Our findings support the continued investigation of GSE as an anti-neoplastic and chemopreventive agent against lung cancer. Cancer Prev Res; 9(12); 925–32. ©2016 AACR.
Cardio-Renal Syndrome Type 4: The Correlation Between Cardiorenal Ultrasound Parameters
Authors: Lai Silvia , Ciccariello Mauro , Dimko Mira , Galani Alessandro , Lucci Silvio , Cianci Rosario , Mariotti Amalia
Published: September 2016

Bakground/Aims: Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk. Methods: A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic parameters. Results: Tricuspid anular plane systolic excursion (TAPSE) and estimated pulmonary artery systolic pressure (ePAPs) showed a statistically significant difference between CKD patients and healthy controls (p<0.001, p=0.05). Also 25 hydroxyvitaminD (25-OH-VitD), parathyroid hormone (iPTH), posphorus, serum uric acid, renal resistive index (RRI) and C-reactive protein (CRP) showed a significant difference between the two groups (p=0.002, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001). Moreover the TAPSE correlated positively with estimated glomerula filtration rate (eGFR) and negatively with RRI (p=0.05, p=0.008), while ePAPs correlated negatively with eGFR and positively with RRI (p=0.029, p<0.001). Conclusion: CKD can contribute to the development and progression of right ventricle dysfunction with endothelial dysfunction, inflammation and mineral metabolism disorders. Accurate assessment of right ventricular function is recommended in patients with CKD. RRI and echocardiographic parameters can be an important instrument for the diagnosis, prognosis and therapeutic assessment of cardio-renal syndrome in these patients.
Circulating CXCL16 in Diabetic Kidney Disease
Authors: Elewa Usama , Sanchez-Niño Maria D. , Mahillo-Fernández Ignacio , Martin-Cleary Catalina , Belen Sanz Ana , Perez-Gomez Maria Vanessa , Fernandez-Fernandez Beatriz , Ortiz Alberto
Published: September 2016

Background/Aims: Chronic kidney disease and, specifically, diabetic kidney disease, is among the fastest increasing causes of death worldwide. A better understanding of the factors contributing to the high mortality may help design novel monitoring and therapeutic approaches. CXCL16 is both a cholesterol receptor and a chemokine with a potential role in vascular injury and inflammation. We aimed at identifying predictors of circulating CXCL16 levels in diabetic patients with chronic kidney disease. Methods: We have now studied plasma CXCL16 in 134 European patients with diabetic kidney disease with estimated glomerular filtration rate (eGFR) categories G1-G4 and albuminuria categories A1-A3, in order to identify factors influencing plasma CXCL16 in this population. Results: Plasma CXCL16 levels were 4.0±0.9 ng/ml. Plasma CXCL16 increased with increasing eGFR category from G1 to G4 (that is, with decreasing eGFR values) and with increasing albuminuria category. Plasma CXCL16 was higher in patients with prior cardiovascular disease (4.33±1.03 vs 3.88±0.86 ng/ml; p=0.013). In multivariate analysis, eGFR and serum albumin had an independent and significant negative correlation with plasma CXCL16. Conclusion: In diabetic kidney disease patients, GFR and serum albumin independently predicted plasma CXCL16 levels.
Lesch-Nyhan Syndrome: Models, Theories, and Therapies
Authors: Bell Scott , Kolobova Ilaria , Crapper Liam , Ernst Carl
Published: September 2016

Lesch-Nyhan syndrome (LNS) is a rare X-linked disorder caused by mutations in HPRT1, an important enzyme in the purine salvage pathway. Symptoms of LNS include dystonia, gout, intellectual disability, and self-mutilation. Despite having been characterized over 50 years ago, it remains unclear precisely how deficits in hypoxanthine and guanine recycling can lead to such a profound neurological phenotype. Several studies have proposed different hypotheses regarding the etiology of this disease, and several treatments have been tried in patients, though none have led to a satisfactory explanation of the disease. New technologies such as next-generation sequencing, optogenetics, genome editing, and induced pluripotent stem cells provide a unique opportunity to map the precise sequential pathways leading from genotype to phenotype.
Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States
Authors: Varvel Steve , McConnell Joseph P. , Tsimikas Sotirios
Published: September 2016

Objective—

Elevated lipoprotein(a) [Lp(a)] is a causal, independent risk factor for cardiovascular disease and aortic stenosis. We aimed to define the prevalence and patient thresholds of elevated Lp(a) levels in the United States.

Approach and Results—

We analyzed Lp(a) levels in 532 359 subjects from 2 data sets: (1) in 531 144 subjects from a referral laboratory and (2) in 915 patients from a tertiary referral center. Lp(a) mass levels were measured by immunoturbidometric assays in both centers and expressed as mg/dL. At the referral laboratory, the median age (interquartile range) of the subjects was 57.0 (46–67) years, and 51.9% were female. Lp(a) levels were skewed rightward as expected. The mean±SD levels were 34.0±40.0 mg/dL, and median (interquartile range) levels were 17 (7–47) mg/dL, with range 0 to 907 mg/dL. Lp(a) levels at 75%, 80%, 90%, 95%, 99%, and 99.9% percentiles were >47, >60, >90, >116, >180, and >245 mg/dL, respectively. At the referral laboratory, Lp(a) levels >30 and >50 mg/dL were present in 35.0% and 24.0% of subjects, respectively, and at the tertiary referral center, 39.5% and 29.2%, respectively. Females had higher mean (SD) (37.0 [42.7] versus 30.7 [36.7];
P
<0.0001) and median (interquartile range) (19 [8–53] versus 15 [7–42];
P
<0.0001) Lp(a) than males.

Conclusions—

This is the largest database to assess the distribution of Lp(a) and is derived from patients as opposed to general populations. Lp(a) levels >30 and >50 mg/dL were fairly common, particularly in a tertiary care setting. These data may inform consensus documents, guidelines, and therapeutic cutoffs for Lp(a)-mediated cardiovascular risk.
Aortic Elastic Properties in Preschool Children Born Preterm
Authors: Odri Komazec Irena , Posod Anna , Schwienbacher Martin , Resch Maria , Pupp Peglow Ulrike , Kiechl Stefan , Baumgartner Daniela , Kiechl-Kohlendorfer Ursula
Published: September 2016

Objective—

Preterm birth predisposes children to the development of cardiovascular diseases in adulthood. The aim of this study was to characterize elastic properties of the aorta at preschool age and test the hypothesis that prematurity is associated with decreased aortic distensibility and increased stiffness, both of which are predictors of increased cardiovascular risk.

Approach and Results—

In an observational study of 76 five- to seven-year-old children born at a gestational age <32 weeks and 79 term-born controls, elastic parameters of the ascending and descending abdominal aorta were determined noninvasively by means of M mode echocardiographic tracings and calculated using computerized wall contour analysis. Compared with children born at term, the preterm group showed significantly reduced distensibility and increased stiffness of the descending abdominal aorta. These results remained significant under multivariable adjustment for birth weight z score, maternal smoking in pregnancy, maternal education, family history of cardiovascular disease, breastfeeding, childhood nutrition, and current body mass index z score (multivariable odds ratios and 95% confidence intervals 5.1, 1.7–15.9;
P
=0.005 and 2.8, 1.0–7.9;
P
=0.046, respectively). Further adjustment for intravenous lipid therapy attenuated the strength of association. Elastic properties of the ascending aorta did not differ between the 2 study groups.

Conclusions—

Children born preterm are characterized by decreased elastic properties of the descending abdominal aorta potentially attributable to impaired viscoelastic properties of and lipid damage to the aorta. Clinical follow-up of preterm infants with a focus on aortic elastic properties may be useful for tailoring early prevention programs and counteracting cardiovascular risk in adulthood.
Fluid-Attenuated Inversion Recovery Vascular Hyperintensity Topography, Novel Imaging Marker for Revascularization in Middle Cerebral Artery Occlusion
Authors: Liu Dezhi , Scalzo Fabien , Rao Neal M. , Hinman Jason D. , Kim Doojin , Ali Latisha K. , Saver Jeffrey L. , Sun Wen , Dai Qiliang , Liu Xinfeng , Liebeskind David S.
Published: September 2016

Background and Purpose—

In acute arterial occlusion, fluid-attenuated inversion recovery vascular hyperintensity (FVH) has been linked to slow flow in leptomeningeal collaterals and cerebral hypoperfusion, but the impact on clinical outcome is still controversial. In this study, we aimed to investigate the association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern and outcome in acute M1-middle cerebral artery occlusion patients with endovascular treatment.

Methods—

We included acute M1-middle cerebral artery occlusion patients treated with endovascular therapy (ET). All patients had diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery before ET. Distal FVH-ASPECTS was evaluated according to distal middle cerebral artery-ASPECT area (M1–M6) and acute DWI lesion was also reviewed. The presence of FVH inside and outside DWI-positive lesions was separately analyzed. Clinical outcome after ET was analyzed with respect to different distal FVH-ASPECTS topography.

Results—

Among 101 patients who met inclusion criteria for the study, mean age was 66.2±17.8 years and median National Institutes of Health Stroke Scale was 17.0 (interquartile range, 12.0–21.0). FVH-ASPECTS measured outside of the DWI lesion was significantly higher in patients with good outcome (modified Rankin Scale [mRS] score of 0–2; 8.0 versus 4.0,
P
<0.001). Logistic regression demonstrated that FVH-ASPECTS outside of the DWI lesion was independently associated with clinical outcome of these patients (odds ratio, 1.3; 95% confidence interval, 1.06–1.68;
P
=0.013). FVH-ASPECTS inside the DWI lesion was associated with hemorrhagic transformation (odds ratio, 1.3; 95% confidence interval, 1.04–1.51;
P
=0.019).

Conclusions—

Higher FVH-ASPECTS measured outside the DWI lesion is associated with good clinical outcomes in patients undergoing ET. FVH-ASPECTS measured inside the DWI lesion was predictive of hemorrhagic transformation. The FVH pattern, not number, can serve as an imaging selection marker for ET in acute middle cerebral artery occlusion.
Long-Term Clinical Impact of Vascular Brain Lesions on Magnetic Resonance Imaging in Older Adults in the Population
Authors: Kaffashian Sara , Soumaré Aïcha , Zhu Yi-Cheng , Mazoyer Bernard , Debette Stéphanie , Tzourio Christophe
Published: September 2016

Background and Purpose—

White matter hyperintensity (WMH) volume and covert brain infarcts are highly prevalent in older adults and are often asymptomatic. We compared the impact of WMH volume and brain infarcts on risk of clinical stroke and dementia in older adults in the population.

Methods—

Participants were 1677 individuals aged ≥65 years from the 3-City Dijon study, who were free of stroke and dementia at baseline, followed-up for ≤12 years.

Results—

Both lesion types were comparably associated with an increased risk of stroke (adjusted hazard ratio, 1.72; 95% confidence interval, 1.24–2.40 for WMH volume and hazard ratio, 2.15; 95% confidence interval, 1.18–3.93 for brain infarcts), but only WMH volume was associated with an increased risk of dementia (hazard ratio, 1.41; 95% confidence interval, 1.09–1.83).

Conclusions—

The differential impact of WMH and brain infarcts on clinical stroke and dementia suggests relatively different prognostic value of the 2 lesions. WMHs may represent a particularly pertinent magnetic resonance imaging intermediate marker that can be utilized in optimizing prevention strategies for both stroke and dementia in primary care and in trials.
Cognitive appraisal of aversive stimulus differs between individuals with contrasting stress coping styles; evidences from selected rainbow trout (Oncorhynchus mykiss) strains
Authors: Moltesen Maria , Vindas Marco Antonio , Winberg Svante , Ebbesson Lars , de Lourdes Ruiz-Gomez Maria , Skov Peter Vilhelm , Dabelsteen Torben , Øverli Øyvind , Höglund Erik
Published: September 2016

In animals, personality variations in response to stress and energy demands have been established. Cognitive processing of negative stimuli correlates with stress response patterns. Still, the relative contribution of cognitive appraisal or physiological demands to the behavioural output needs to be clarified. In this study we utilized reactive (high-responsive, HR) and proactive (low-responsive, LR) rainbow trout strains to investigate how contrasting reactions to hypoxia are related to individual variation in metabolism and/or cognition. The HR-LR strains did not differ in standard metabolic rate or hypoxia tolerance. HR trout displayed more pronounced avoidance to a signal cue after being conditioned with hypoxia, suggesting that they experienced this stimulus more aversive than LR trout. Together with differences in forebrain c-fos activation patterns in dorsomedial pallium, these results suggest cognitive differences between the strains. These results demonstrate that differences in personality/stress coping style can be related to contrasts in cognition, which are independent of metabolic differences.
Funding the eu–Morocco ‘Mobility Partnership’: Of Implementation and Competences
Authors: den Hertog Leonhard
Published: September 2016

This article explores the role of funding under the ‘Mobility Partnership’ (mp) concluded between the European Union (eu), various Member States and Morocco. As most academic literature and policy discourse assumes a link between funding and policy implementation, this article enquires into how funding can help us understand implementation and the priorities set therein, and what alternative understandings of funding we could develop. By presenting evidence from the eu-Morocco mp, it is argued that looking at eu funding obscures rather than clarifies the priorities pursued in the cooperation on borders, asylum and migration. Drawing from the political sociology of public finances and from legal literature, this article understands funding as embedded in institutional, legal and political struggles over competences, and highlights the symbolic nature of funding.
What about Refugees with Disabilities? The Interplay between eu Asylum Law and the un Convention on the Rights of Persons with Disabilities
Authors: Conte Carmine
Published: September 2016

Refugees with disabilities represent an invisible group of individuals who are forced to leave their countries in particularly disadvantaged situations. Therefore, they are in need of special protection and attention, especially at the European level because of the ongoing dramatic humanitarian emergency. This article seeks to examine to what extent the un Convention on the Rights of Persons with Disabilities can be applied to refugees. Moreover, the paper looks at the Directives of the Common European Asylum System in order to examine whether the eu legal backdrop takes into account the peculiar condition of refugees with disabilities.
Demagogues and Demos in Athens
Authors: Rhodes P.J.
Published: September 2016

M. I. Finley sought to rescue the ‘demagogue’ as an essential ingredient in Athens’ democratic processes. This paper explores the interactions of politicians and the assembly.

There is some evidence for pressure on men to attend and to vote on a particular side. There were many occasional speakers and proposers in addition to the few most active politicans. We should not think of a series of duels; and experienced assembly-goers were not mere ‘spectators of speeches’. Speakers could be supported by cheers or heckled. Nobody could count on the assembly’s voting as he wanted consistently time after time.

Politicians sought to cultivate an image, whether the aloof, magisterial image of Pericles or the extravagantly populist image of Cleon. Orators had to master a range of strategies to succeed, but there was not a simple division between élite politicians and a lower-class demos to whose tune they had to dance.
The genus Zelurus Hahn, 1826, in Brazilian caves: description of new species and comments on the potential distribution of the genus in South America
Authors: FERREIRA MARINA IZABEL GRAVE , FERREIRA RODRIGO LOPES , GIL-SANTANA HÉLCIO R.
Published: September 2016

A survey on species of the genus Zelurus Hahn, 1826 (Reduviidae) occurring in Brazilian caves is provided. Zelurus tambejua sp. n. and Zelurus gerevatinga sp. n. collected from caves in Brazil are described. Comments about the current and potential distribution of the genus as a whole and of species of Zelurus found in caves for South America are also provided.
A new species of the Cyrtodactylus (Geckoella) collegalensis (Beddome, 1870) complex (Squamata: Gekkonidae) from Western India
Authors: AGARWAL ISHAN , MIRZA ZEESHAN A. , PAL SAUNAK , MADDOCK SIMON T. , MISHRA ANURAG , BAUER AARON M.
Published: September 2016

A new species of Cyrtodactylus (Geckoella) from the C. collegalensis complex is described based on a series of specimens from western and central India. Morphological and molecular data support the distinctiveness of the new form, which can be diagnosed from other Cyrtodactylus (including other Geckoella) species by its small body size (snout to vent length to 56 mm), the absence of precloacal and femoral pores, no enlarged preanal or femoral scales, and a dorsal scalation consisting wholly of small, granular scales. The new species is most closely related to C. collegalensis, C. speciosus and C. yakhuna, from which it differs by the presence of a patch of enlarged roughly hexagonal scales on the canthus rostralis and beneath the angle of jaw, its relatively long limbs and narrow body, and a dorsal colour pattern of 4–6 pairs of dark spots.
Extreme Rainfall from Landfalling Tropical Cyclones in the Eastern United States: Hurricane Irene (2011)
Authors: Liu Maofeng , Smith James A.
Published: September 2016

Hurricane Irene produced catastrophic rainfall and flooding in portions of the eastern United States from 27 to 29 August 2011. Like a number of tropical cyclones that have produced extreme flooding in the northeastern United States, Hurricane Irene was undergoing extratropical transition during the period of most intense rainfall. In this study the rainfall distribution of landfalling tropical cyclones is examined, principally through analyses of radar rainfall fields and high-resolution simulations using the Weather Research and Forecasting (WRF) Model. In addition to extratropical transition, the changing storm environment at landfall and orographic precipitation mechanisms can be important players in controlling the distribution of extreme rainfall. Rainfall distribution from landfalling tropical cyclones is examined from a Lagrangian perspective, focusing on times of landfall and extratropical transition, as well as interactions of the storm circulation with mountainous terrain. WRF simulations capture important features of rainfall distribution, including the pronounced change in rainfall distribution during extratropical transition. Synoptic-scale analyses show that a deep baroclinic zone developed and strengthened in the left-front quadrant of Irene, controlling rainfall distribution over the regions experiencing most severe flooding. Numerical experiments were performed with WRF to examine the role of mountainous terrain in altering rainfall distribution. Analyses of Hurricane Irene are placed in a larger context through analyses of Hurricane Hannah (2008) and Hurricane Sandy (2012).
The Development and Evaluation of a Statistical–Dynamical Tropical Cyclone Genesis Guidance Tool
Authors: Halperin Daniel J. , Hart Robert E. , Fuelberg Henry E. , Cossuth Joshua H.
Published: September 2016

The National Hurricane Center (NHC) has stated that guidance on tropical cyclone (TC) genesis is an operational forecast improvement need, particularly since numerical weather prediction models produce TC-like features and operationally required forecast lead times recently have increased. Using previously defined criteria for TC genesis in global models, this study bias corrects TC genesis forecasts from global models using multiple logistic regression. The derived regression equations provide 48- and 120-h probabilistic genesis forecasts for each TC genesis event that occurs in the Environment Canada Global Environmental Multiscale Model (CMC), the NCEP Global Forecast System (GFS), and the Met Office's global model (UKMET). Results show select global model output variables are good discriminators between successful and unsuccessful TC genesis forecasts. Independent verification of the regression-based probabilistic genesis forecasts during 2014 and 2015 are presented. Brier scores and reliability diagrams indicate that the forecasts generally are well calibrated and can be used as guidance for NHC’s Tropical Weather Outlook product. The regression-based TC genesis forecasts are available in real time online.