bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitral Valve Aneurysms Complicating Aortic Valve Endocarditis: A Case Series.
Authors: AGRAWAL DR SHRIRAM , KUMAR DR M VIJAY , C DR RAJIV , VERMA DR PRAVIN
Published: February 2025

Background: Mitral valve aneurysms (MVAs) are uncommon conditions frequently associated with aortic valve endocarditis. They may be complicated by perforation and severe mitral regurgitation (MR). Optimal treatment of MVA, and in particular the best timing for surgery, are uncertain.
Case Presentation: We report three cases of MVAs complicating aortic valve endocarditis:
Case 1: A 56-year-old male with acute pulmonary edema secondary to severe aortic and mitral regurgitation underwent emergency double valve replacement. Despite initial postoperative stability, he later succumbed to complications.
Case 2: A 33-year-old female developed severe regurgitation of both valves and multiple cerebral infarctions post-febrile illness. Due to the COVID-19 pandemic, her double valve replacement was delayed, but she recovered well after surgery.
Case 3: A 41-year-old male, initially evaluated for renal transplant, was incidentally found to have severe aortic regurgitation and MVA. He successfully underwent elective aortic valve replacement and mitral valve repair.
Details: The first patient had Severe AR and MR, presented with pulmonary edema, and underwent double valve replacement. The second patient had a prolonged course of relapsing and remitting fever for one and half years which was initially treated by broad-spectrum antibiotics, complicated by CVA, had severe MR and AR, and underwent double valve replacement. The third patient had unexplained pulmonary edema even after regular dialysis and as a pre-operative check-up had AV endocarditis with MVA causing severe AR and MR   and underwent AVR with MV repair. All patients had mechanical valves for replacement and MV repair by pericardial patch.
Conclusions: MVAs are infrequent but potentially severe complications of AV endocarditis. In the absence of definite treatment indications, the correct time for surgery should depend on concomitant clinical and infective features.
Impact des mesures prudentielles et de la politique monétaire sur les prêts hypothécaires dans la CAE
Authors: Sebasore Bahati
Published: February 2025

Cet article analyse l'impact des mesures prudentielles et de la politique monétaire sur les prêts hypothécaires dans la Communauté de l'Afrique de l'Est (CAE) entre 1990 et 2020. L'objectif est d'évaluer comment ces facteurs influencent les prêts hypothécaires dans la région. En utilisant des données de la Banque mondiale et des banques nationales, le test de Hausman a orienté l'analyse vers un modèle à effets aléatoires. Les résultats montrent que la politique monétaire, le total des actifs bancaires, et le nombre de guichets automatiques ont un effet positif significatif sur les prêts hypothécaires. En revanche, le PIB, les succursales bancaires, la qualité des institutions, et la stabilité politique ont une influence négative. Les mesures prudentielles n'ont pas d'effet direct significatif sur les prêts hypothécaires. L'étude est limitée par la période d'analyse et l'absence de certaines variables nationales spécifiques. Des recherches futures devraient inclure des périodes plus longues et des variables additionnelles pour affiner les résultats. Une analyse comparative avec d'autres régions en développement et une exploration approfondie de l'infrastructure bancaire pourraient enrichir les conclusions.
The Impact of Life Meaning and Spiritual Well-Being on the Quality of Life in Patients with Chronic Kidney Failure at Purbalingga Hospital
Authors: Munjiati
Published: February 2025

Chronic Kidney Failure (CKD) is a progressive and irreversible condition that necessitates lifelong renal replacement therapies such as hemodialysis or kidney transplantation. Globally, the prevalence of CKD has risen significantly, accompanied by high mortality and morbidity rates. In Indonesia, CKD continues to grow as a public health challenge, with many patients reliant on hemodialysis, which, while improving survival, brings physical, psychological, social, and financial burdens. These challenges often lead to diminished quality of life, emphasizing the need for holistic support systems.
This study highlights the critical role of spiritual well-being and the sense of meaning in life in enhancing the quality of life for CKD patients undergoing hemodialysis. Spiritual well-being fosters hope and acceptance, empowering patients to cope with chronic illness while finding meaning amidst adversity. A higher sense of spiritual and existential well-being correlates positively with improved physical, psychological, social, and environmental health domains. By integrating spiritual well-being with the concept of meaning in life, patients can achieve greater resilience and an enhanced quality of life. This therapeutic interplay underscores the need for comprehensive interventions that address not only physical health but also the psychosocial and spiritual dimensions of CKD care.
Reconstruction of Kharkiv in 1943–1945
Authors: Diakova Olena , Topchiі Daniil
Published: February 2025

The events of the Second World War brought immense suffering and devastation to countries around the world, and the USSR, including Ukraine, was no exception. Almost 80 years ago, the liberation of Ukrainian territories from German invaders began, including the liberation of Kharkiv on August 23, 1943. From that day on, a complex and necessary process of rebuilding the city commenced, not only by its residents but also with the support of other republics of the USSR. Today, in the face of Russian aggression in Ukraine, Kharkiv once again finds itself under the threat of destruction. This paper examines similar events that occurred in the 20th century and the study of how the city was rebuilt during the war, with the aim of not only quickly restoring industries and institutions but also providing proper living conditions for its residents.
This article aims to identify the priority areas for the reconstruction of Kharkiv during the war years (August 1943–May 1945). It can be argued that two primary objectives existed: rebuilding industry and addressing social issues. Providing housing, adequate nutrition, and medical care were crucial not only for improving people's daily lives but also for increasing labour productivity. The local leadership utilised the joy of liberation and the belief in victory over Nazism to mobilise the city's residents for unpaid work during their free time, compelling them to address most of their household needs independently. However, those involved in the reconstruction of Kharkiv did not bear grudges against the city authorities for these measures; they understood the necessity of quickly restoring normal life and considered the inconveniences to be temporary.
The article emphasises the importance of defining priorities for reconstruction of the economy and improving the living conditions of the population. To achieve these goals, organised leadership, community participation, and individual citizen participation were necessary.
FAMILY HISTORY, KNOWLEDGE, AND RESTING PATTERNS ASSOCIATED WITH HYPERTENSION: CASE-CONTROL STUDY
Authors: Rizqiyah Syafitri Nadia , Qurniyawati Eny , Nityasani Renaningtyas , Ssekalembe Geofrey
Published: February 2025

Background: Non-communicable diseases are the leading cause of death worldwide, responsible for approximately 75% of global mortality. Hypertension, a significant contributor to NCD-related deaths, affects an estimated 1.28 billion adults globally and is often referred to as "The Silent Killer." The increasing prevalence of NCDs, including hypertension, poses significant challenges to the global health system. In Ponorogo Regency, hypertension cases surged from 41,841 in 2021 to 126,668 cases in 2023. Analyzing the risk factors of hypertension is essential to mitigate its health impact on the community. Purpose: To analyze the risk factors of hypertension cases in the Plosojenar Village, Ponorogo Regency community. Methods: This quantitative study employed a case-control design with 154 participants. The case group comprised 77 individuals with hypertension, and the control group included 77 non-hypertensive individuals, selected through random sampling at a 1:1 ratio. Data were collected from January to April 2024 using questionnaires. Bivariate analysis was conducted using Chi-square and Fisher’s tests. Results: This study found a significant association between family history OR 13.67 (95%CI = 5.63 - 39.17); p = 0.00, level of knowledge OR 26.25 (95%CI = 3.96 - 1.11); p = 0.05, and rest habits OR 0.18 (95%CI = 0.03 - 0.70); p = 0.08 to hypertension cases. This study also showed no significant relationship between attitude OR 0.88 (95%CI = 0.32 - 2.37); p = 1 with hypertension cases. Conclusion: Family history, knowledge level, and rest habits are significantly associated with hypertension. Targeted interventions addressing these factors may help reduce hypertension cases.
A CROSS-SECTIONAL STUDY: THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND MENTAL WORKLOAD AMONG HOUSEWIVES
Authors: Wahyu Ismiyasa Suci , Mailani Rena
Published: February 2025

Background: The role of housewives, particularly those with toddlers, is physically and mentally demanding, often leading to high stress levels and workload. Purpose: This study examined the relationship between physical activity and mental workload among homemakers. Methods: A cross-sectional design was employed, utilizing the IPAQ-SF and RSME questionnaires to assess physical activity and mental workload. The study included 46 participants, most of whom were young mothers with one child and had a high school education. Results: The mothers had a high level of physical activity (16,479.85 ± 16,983.35 MET-min/week) and experienced a considerably quite large workload (mean score: 72.90). However, there was no significant relationship between physical activity and mental workload (β = 0.28, p > 0.05). Conclusion: These findings suggest that the physical and mental demands on homemakers are substantial, yet these factors may not directly influence their life satisfaction, highlighting the need for further research into the contributors to their well-being.
ISIL-Taliban: An Existential Confrontation of Regional Significance in Afghanistan
Authors: Machitidze G.
Published: February 2025

The article is devoted to the nature and consequences of the existential confrontation of regional significance between ISIL-Khorasan and the Taliban in the modern conditions that have developed in recent years against the background of significant differences between the terrorist organization and the Taliban in power. The author emphasizes that the serious rivalry between the two Islamist organizations for the “minds and sentiments” of the people has to a large extent acquired an existential character. The author states the global nature and goal of ISIL-Khorasan to create a transnational caliphate in the historical area of Greater Khorasan, which is completely different from the Taliban’s national agenda. It is emphasized that the group pays great attention to discrediting rival jihadist organizations and religious figures who oppose it. It emphasizes the aggressive nature of ISIL-Khorasan, which has plans to overthrow the governments of regional states. ISIL-Khorasan’s campaign of recruitment of Afghans and ideological propaganda led to armed conflict with the Taliban. It notes the remarkable resilience of ISIL-Khorasan, despite heavy losses, and strengthening of the group’s position after the Taliban came to power in Afghanistan. It is concluded that the ongoing terrorist activity of ISIL-Khorasan leads to the undermining of Kabul’s efforts to stabilize the internal situation in the country, complicates the solution of humanitarian and socio-economic problems, discredits the Taliban regime in the eyes of the local population and the international community, and poses a threat to regional states.
Educational Migration in Eurasia: the Case of Kazakhstan
Authors: Pogorelskaya A. , Pokrovskaia A.
Published: February 2025

The article investigates the dynamics of educational migration from Kazakhstan and identifies factors influencing the attraction of foreign students. It traces the evolution of Kazakhstan’s educational policy from the 1990s, highlighting significant initiatives like the “Bolashak” program and the country’s integration into the European Higher Education Area. The study emphasizes the measures taken to enhance the accessibility and quality of higher education, including the establishment of foreign university branches in Kazakhstan. Using regression analysis, the research identifies key factors influencing educational migration, such as urbanization level, Internet accessibility, and the number of students enrolled in higher education. The analysis reveals a strong positive correlation between the percentage of Internet users and student outflows, indicating the role of digital information in shaping students’ decisions to study abroad. Conversely, urbanization and the number of graduates show a positive impact on attracting foreign students to Kazakhstan. The article also discusses the country’s strategic efforts to become a regional hub for student mobility, particularly through the creation of the Central Asian Higher Education Area (CAHEA). It evaluates recent policies aimed at increasing the proportion of foreign students and the challenges faced in implementing these initiatives. The practical significance of this research lies in its potential to inform policymakers about effective strategies to manage educational migration. By analyzing the relationship between educational policies and migration patterns, the study offers insights into enhancing Kazakhstan’s attractiveness as a destination for higher education. The findings highlight the importance of urban educational centers and digital infrastructure in supporting the country’s educational goals and reducing brain drain.
« Résoudre le syndrome de la page blanche de Laurine ». Quand le dispositif échoue ou qu’il réussit trop bien
Authors: Lebrun Léo
Published: February 2025

Cet article est une « monographie », au sens où la définit la Pédagogie Institutionnelle. Écrite par quatre formateurs en travail social, elle donne à voir une situation de blocage face à l’écriture, blocage nommé par l’étudiante concernée comme le résultat du « syndrome de la page blanche ». Le formateur engagé dans cette situation partage avec trois de ses collègues formateurs des réflexions et des hypothèses d’analyse autour de ce que cet empêchement et sa propre volonté de résoudre « à tout prix » ce problème peuvent signifier. L’introduction et la première partie du texte donnent des éléments permettant de comprendre ce qu’est une monographie, à la fois en tant que processus d’élaboration sur la pratique et en tant que production d’un type particulier d’écrit professionnel. La seconde partie de l’article est la monographie proprement dite.
Action for cognitive biases in clinical decision-making
Authors: Cioffi Jane
Published: February 2025

Clinical practice demands quick and accurate decision-making. However, these decisions are susceptible to cognitive biases, and clinicians need to be open to the possibility of biased thinking. Actions to address cognitive biases are needed in practice and through education to continuously increase clinicians’ insight and understanding and enable the application of interventions. This article identifies and explains biases in clinical decision-making, discusses debiasing interventions for use by clinicians, and proposes research directions.
Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors
Authors: von Delft Frank , Ni Xiaomin , Richardson R. , Godoy Andre , Ferla Matteo , Kikawa Caroline , Scheen Jenke , Hannon William , Capkin Eda , Lahav Noa , Balcomb Blake , Marples Peter , Fairhead Michael , Wang SiYi , Williams Eleanor , Tomlinson Charles , Aschenbrenner Jasmin , Lithgo Ryan , Winokan Max , Giroud Charline , Chandran Anu , Walsh Martin , Thompson Warren , Bloom Jesse , Barr Haim , Kirkegaard Karla , Koekemoer Lizbé , Fearon Daren , Evans Matthew
Published: February 2025

The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target. Generation of a robust crystal system of co-expressed NS2B-NS3 protease has enabled us to perform a crystallographic fragment screening campaign with 1076 fragments. 47 fragments with diverse scaffolds were identified to bind in the active site of the protease, with another 6 fragments observed in a potential allosteric site. To identify binding sites that are intolerant to mutation and thus suppress the outgrowth of viruses resistant to inhibitors developed from bound fragments, we performed deep mutational scanning of NS2B-NS3 protease. Merging fragment hits yields an extensive set of ‘mergers’, defined as synthetically accessible compounds that recapitulate constellations of observed fragment-protein interactions. In addition, the highly sociable fragment hits enable rapid exploration of chemical space via algorithmic calculation and thus yield diverse possible starting points that maximally explore the binding opportunities to NS2B-NS3 protease, facilitating its resistance-resilient antiviral development.
Handling electric connections in 3D-printed electrodes and sensors. Part II. Instrumentation
Authors: de Oliveira Thawan Gomes , Verlangieri Ivan , Lopes Fernando Silva , Gutz Ivano Gebhardt Rolf , Angnes Lúcio , Lago Claudimir Lucio do
Published: February 2025

This study explores the integration of 3D-printed electrodes made from carbon black-poly(lactic acid) (CB-PLA) into electrochemical sensors, focusing on the challenges posed by the polymer/metal electrical contact resistance (ECR) and Ohmic drop. We demonstrate that while CB-PLA electrodes offer promising potential for sensor applications, the ECR and intrinsic resistance of printed tracks can significantly affect the performance. We propose the use of a four-electrode potentiostat, which allows for dynamic compensation of Ohmic drop, thereby enhancing the reliability of measurements. We conducted cyclic voltammetry experiments using a custom-built 3D-printed electrode with dual conducting tracks to independently monitor potential and current. The results obtained with a commercial four-electrode potentiostat were compared to those from a conventional three-electrode potentiostat. To enable users without a four-electrode potentiostat to use the described electrode, a four-electrode potentiostatic module (FEPM) was developed. The results from combining a three-electrode instrument with the FEPM are comparable to those from a commercial four-electrode instrument. Quantitative analysis revealed that the peak current varied linearly with analyte concentration (R² = 0.992) and with the square root of the scan rate, showing high correlation coefficients for both cathodic (R² = 0.993) and anodic (R² = 0.999) peak currents. Differential pulse voltammetry experiments further confirmed the improved performance of the four-electrode setup, with comparable results obtained using the three-electrode potentiostat and FEPM combination. These findings underscore the importance of careful instrumentation design when integrating 3D-printed components into electrochemical systems, and suggest practical approaches for mitigating ECR and Ohmic drop in such applications.
Research on the Impact of Excessive Environmental Information Disclosure by Enterprises on Stock Price Crash
Authors: Dong Guoping , Ma Guifen
Published: February 2025

This paper investigates the phenomenon of excessive environmental information disclosure by A-share listed companies in China. Using a sample of A-share listed companies that published corporate social responsibility (CSR) reports between 2015 and 2023, the study first applies the threshold effect and quantile regression models to identify embellishments in the environmental textual information disclosed by these firms. Subsequently, a panel fixed effects model is employed to examine the potential impact of excessive environmental information disclosure on stock price crashes. The results reveal that the environmental textual information disclosed by companies contains embellishments beyond substantive environmental content, indicating the presence of greenwashing. This behavior amplifies the risk of stock price crashes, with a more pronounced effect in the manufacturing sector. The underlying mechanism is that excessive textual information disclosure diminishes the quality and transparency of the disclosed information, thus fostering irrational investment behaviors among investors. Additionally, the study finds that effective environmental textual information disclosure can attenuate the likelihood of stock price crashes. Further analysis suggests that reducing ownership concentration, increasing managerial equity ownership, and enhancing the role of independent directors in corporate governance can significantly improve the quality of environmental information disclosure and curb excessive environmental information embellishment. This paper provides new insights into the analysis of environmental textual information disclosure and offers practical implications for guiding investors toward more rational investment decisions.
CircRNA signatures define ATLL subtypes and uncover the HBZ-DHX9 axis in tumor survival
Authors: Ladet Julien , Bazire Mateo , Fontrodona Nicolas , Broeke Anne Van den , Marçais Ambroise , Shallak Mariam , Forlani Greta , Accolla Roberto S. , Bourgeois Cyril F. , Mortreux Franck
Published: February 2025

Circular RNAs (CircRNAs) are emerging as critical regulators in leukemia biology; however, their role in Adult T-cell Leukemia/Lymphoma (ATLL) remains unexplored. In this study, we provide the first comprehensive profiling of circRNAs in ATLL subtypes, uncovering distinct circRNA signatures in acute, chronic, and lymphoma forms of the disease. Notably, circAFF2(3) was markedly upregulated in aggressive ATLL subtypes, suggesting its involvement in disease progression. Functional assays revealed that circAFF2(3) promotes cell viability in HTLV-1-transformed T cells, highlighting its potential as a tumor-promoting factor. Mechanistically, we demonstrate that the HTLV-1 viral protein HBZ interacts with the RNA helicase DHX9, a key regulator of circRNA biogenesis, and inhibits its unwinding activity at intronic regions flanking circularized exons, including those responsible for circAFF2(3) production. These findings establish the HBZ-DHX9 axis as a critical mechanism driving circRNA dysregulation and tumor survival in ATLL, offering new opportunities for biomarker discovery and therapeutic intervention.
Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma Cells
Authors: Wang Yanfeng , Jiang Beier , Yin Yichen , Li Tao , Chen Jing
Published: February 2025

B-cell lymphoma 6 (BCL6) is a transcriptional repressor essential for B lymphocyte differentiation and germinal center formation through its BTB structural domain. Overexpression of BCL6 is strongly implicated in the progression of diffuse large B-cell lymphoma (DLBCL), making it a promising therapeutic target. This study aims to identify a novel small molecule, synthesized via proteolysis-targeting chimeras (PROTACs), capable of degrading BCL6, thereby inhibiting DLBCL growth and providing a foundation for future preclinical studies. The expression of BCL6 in DLBCL was analyzed using The Cancer Genome Atlas (TCGA) database and the Human Protein Atlas. Western blotting assays confirmed BCL6 expression in tumor cell lines, leading to the identification of the small molecule compound DZ-865B. To evaluate DZ-865B’s in vitro efficacy, multiple assays were performed, including protein immunoblotting, immunofluorescence, quantitative PCR, EDU proliferation, and soft agar cloning assays. TCGA analysis revealed significant overexpression of BCL6 in DLBCL (P < 0.05), corroborated by immunohistological staining and western blotting. DZ-865B induced BCL6 degradation in DLBCL cell lines (OCI-LY-1 and SU-DHL-4) in a concentration- and time-dependent manner, reducing nuclear BCL6 levels. Notably, DZ-865B did not alter BCL6 mRNA levels but modulated downstream gene expression, leading to the activation of apoptosis pathway proteins and inhibition of DNA synthesis, effectively suppressing DLBCL cell growth. This study demonstrates that the small molecule DZ-865B targets and degrades BCL6 in DLBCL cells, promoting apoptosis and inhibiting cellular proliferation. These findings highlight DZ-865B as a potential therapeutic agent for diffuse large B-cell lymphoma.
Parental Involvement in Language Development: A Comparative Synthesis of Bilingual and Monolingual Children
Authors: GAY ERWIN
Published: February 2025

Background
Parental involvement is recognized as essential for the educational success of young children, facilitating academic achievement and socio-emotional and cognitive development. This paper integrates current research on parental involvement in bilingual and monolingual children aged 3 to 8, emphasizing the impact of these practices on language, literacy, and cognitive development. This study employs an inductive synthesis approach to highlight the similarities and differences in parental strategies, particularly in managing linguistic complexities in bilingual versus monolingual households. It examines the distinct challenges bilingual families face, such as balancing two languages and preserving cultural identity, compared to the more straightforward approaches of monolingual families, which typically emphasize one language.
Results
The findings indicate that bilingual children benefit from metalinguistic awareness and cognitive flexibility due to their exposure to two languages, while monolingual children often experience accelerated proficiency in their primary language. The study also underscores the importance of targeted interventions for both groups, suggesting that bilingual families require support in managing language exposure, while monolingual families may need assistance in overcoming socioeconomic barriers to literacy.
Conclusion
The paper provides practical insights for educators, policymakers, and families to create targeted interventions that foster children’s equitable developmental opportunities in varied linguistic contexts.
Duplication mesenterial cysts (enterocystoma): clinical observation
Authors:   Ogarev Mordovia State University, Z. Almyashev Ali , M. Vesnushkin Georgy ,   Republican Oncology Dispensary, V. Gorgan Irina ,   Ogarev Mordovia State University, E. Mayorov Aleksandr ,   Ogarev Mordovia State University, V. Begoulov Igor ,   Ogarev Mordovia State University
Published: February 2025

Background. Mesenteric cysts are a rare pathology in the practice of a surgeon or oncologist. There is no specific clinical picture; most often they are detected accidentally or when complications develop. The purpose of the study was to evaluate the diagnostic capabilities and management tactics of a patient diagnosed with a mesenteric cyst. Materials and methods. This article presents our own clinical observation of a 27-year-old patient diagnosed with “Borderline enterocystoma of the mesentery of the jejunum”. Result and conclusions. The “gold” standard for this pathology is complete surgical removal of the cyst - laparoscopically or openly.
Association between Insulin-Like Growth Factor Binding Protein-7 and Heart Failure
Authors: Ghasempour Parisa , Khanmohammadi Shaghayegh , Rezaei Nima
Published: February 2025

Heart failure (HF), a widespread public health issue, affects about 26 million
people all around the world, and its incidence and prevalence are still growing. Measuring
serum biomarkers is beneficial in diagnosing HF and evaluating its prognosis. During
the previous decade, various investigations have focused on identifying new HF biological
markers that would have additional and/or superior prognostic, diagnostic, or
classification value. While heart-specific biological markers, such as atrial natriuretic
peptide (ANP) and brain natriuretic peptide (BNP), are commonly applied in clinical
practice, there is still an unmet need for new markers in HF management. Insulin-like
growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, has been considered
as a candidate biomarker in HF. This study aims to comprehensively reveal the
underlying mechanism connecting IGFBP-7 to HF and review studies evaluating the
prognostic or diagnostic performance of IGFBP-7 in combination with or in contrast
with other potential HF biological markers. Increased IGFBP7 levels are associated with
a set of functional and structural heart abnormalities such as diastolic dysfunction. Increased
IGFBP7 concentrations seem to be an indicator of cardiac overload or injury
and are related to HF major risk factors, including atherosclerosis, diabetes, and renal
function. IGFBP7 is predictive of short and long-term outcomes in the HF population
and can independently predict the rate of hospitalization and HF-related mortality.
Engineered Anti-Microbial Peptides Inhibit Cell Viability, Promote Apoptosis, and Induce Cell Cycle Arrest in SW620 Human Colon Adenocarcinoma Cells
Authors: Hashem Sheema , Bhat Ajaz A. , Nisar Sabah , Uddin Shahab , Merhi Maysaloun , Mateo Jericha M. , Prabhu Kirti S. , Soubra Lama , dos Santos Silva Carlos André , Benko-Iseppon Ana Maria , Vilela Lívia Maria Batista , de Lima Marx Oliveira , da Silva Juliana Georgia , Haris Mohammad , Suleman Muhammad , Crovella Sergio , Abou Saleh Haissam
Published: February 2025

Background:

Colorectal cancer (CRC) is one of the most common malignancies worldwide,
and despite advances in treatment, there remains a critical need for novel therapeutic approaches.
Recently, anti-microbial peptides (AMPs) have gained attention for their potential use
in cancer therapy due to their selective cytotoxicity towards cancer cells.

Objective:

This study aims to evaluate the anti-cancer potential of two computationally engineered
anti-microbial peptides (EAMPs) in SW620, SW480, and HCT116 colon cancer cells and
the normal colon epithelial cell line CCD 841, focusing on their effects on cell proliferation, apoptosis,
and DNA damage.

Method:

Cell proliferation and survival were measured using the CellTiter-Glo Luminescence and
clonogenic assays. DNA damage was assessed through the Terminal deoxynucleotidyl transferase
dUTP nick end labeling (TUNEL) assay. Flow cytometry was used to examine cell apoptosis, cell
cycle distribution, and mitochondrial membrane potential in SW620 cells.

Results:

EAMPs inhibited CRC cell proliferation in a dose-dependent manner, with minimal toxicity
observed in normal colon epithelial cells. In SW620 cells, EAMPs induced DNA damage, resulting
in cell cycle arrest at the S/G2 phase, apoptosis, and a reduction in mitochondrial membrane
potential. The proliferation results were confirmed in SW480 and HCT116 CRC cell lines.

Conclusion:

Our findings revealed that EAMPs exhibited significant anti-cancer activity against
CRC cells in vitro while sparing normal epithelial cells. These results suggest that EAMPs may offer
a potential therapeutic approach for colorectal cancer and warrant further investigation.
Parkinson's Disease: From Bench to Bedside-Advancements in Diagnosis and Therapeutics using Pharmacogenomic Approach
Authors: M Suhas , Kadiri Sunil Kumar
Published: February 2025

This article provides a detailed look at Parkinson's disease (PD), a neurodegenerative
ailment mostly known for movement difficulties such tremor, stiffness, and bradykinesia, which affects
approximately 1% of persons over the age of 60. Although the precise cause of PD is still unknown,
various factors such as pesticide exposure, genetics, and lifestyle choices like smoking and
caffeine consumption are thought to play a role in its development. The presence of Lewy bodies
characterizes the disease, the aggregation of alpha-synuclein, the loss of dopaminergic neurons in
the substantia nigra, and disruptions in basal ganglia circuitry, resulting in both motor and nonmotor
symptoms. This review is structured into several key sections, beginning with an exploration
of the pathophysiological mechanisms behind PD, including how genetic mutations can lead to deficits
in the Ubiquitin Proteasome System and mitochondrial function, which are linked to familial
cases of the disease. Following this, the article explores diagnostic methods, such as the UK Brain
Bank Criteria, advanced imaging techniques, olfactory testing, and innovative technologies like
machine learning, all of which support early detection and accurate diagnosis of PD. Treatment
strategies are also comprehensively reviewed, focusing on traditional pharmacological options like
levodopa and dopamine agonists, as well as surgical interventions such as deep brain stimulation.
Additionally, the review discusses promising new therapies, including immunotherapy aimed at
neuroinflammation and gene therapy for disease modification. The impact of lifestyle changes such
as exercise and diet on reducing PD risk and enhancing symptom management are also considered.
In conclusion, this review highlights the complex nature of Parkinson's disease and underscores the
need for a holistic approach that combines pharmacotherapy, advanced treatments, and lifestyle adjustments.
By addressing both symptom management and disease modification, these strategies
provide hope for improving quality of life.
Predictive Accuracy of 24-Hour Ambulatory Blood Pressure Monitoring Versus Clinic Blood Pressure for Cardiovascular and All-Cause Mortality: A Systematic Review and Meta-Analysis
Authors: Soleimani Hamidreza , Mohammadi Negin Sadat Hosseini , Montazeri Namin Sara , Nasrollahizadeh Amir , Azardar Tara , Najafi Kimia , Cilingiroglu Mehmet , Syed Mushabbar , Askari Mani K. , Gupta Rahul , Aronow Wilbert S. , Hosseini Kaveh
Published: February 2025

Background:

According to current clinical practice guidelines, ambulatory blood pres-sure measurement (ABPM) is recommended to confirm diagnoses of hypertension. It remains un-clear as to which method is superior in predicting mortality outcomes.

Methods:

Prospective observational studies, comparing ABPM with clinical blood pressure meas-urements (CBPM), were included with outcomes of the study being all-cause and cardiovascular mortality.

Results:

Nine studies with a total of 23,140 participants were included. Each 10-mmHg increase in 24-hour mean systolic blood pressure (SBP) was linked to a higher risk of all-cause mortality (HR: 1.13, 95% CI: 1.09–1.18), while clinic blood pressure measurement (CBPM) was not a sig-nificant predictor (HR: 1.02, 95% CI: 0.90–1.13). Nighttime SBP increases of 10 mmHg were associated with a higher all-cause mortality risk than daytime SBP (HR: 1.16, 95% CI: 1.11–1.21 versus HR: 1.08, 95% CI: 1.05–1.12). For cardiovascular mortality, a 10 mmHg increase in SBP yielded an HR of 1.21 (95% CI: 1.16–1.27) for 24-hour ABPM compared to 1.08 (95% CI: 1.04–1.11) for CBPM. Similarly, for a 5 mmHg increase in diastolic blood pressure (DBP), the HR was 1.14 (95% CI: 1.07–1.20) for 24-hour ABPM versus 1.04 (95% CI: 1.01–1.07) for clinical DBP, highlighting 24-hour monitoring as a stronger predictor for cardiovascular mortality.

Conclusion:

The findings of this study support the superiority of ABPM measurements in predict-ing both all-cause and cardiovascular mortality.
Digital Economy and Carbon Neutral Technological Innovation
Authors: Wang Ruiqi
Published: February 2025

To achieve sustainable development, improve global competitiveness, promote ecological civilization building, and ease economic transition and upgrading, carbon neutral technical innovation is essential. This paper examines the effect with panel data from 270 Chinese from 2006 to 2022, as well as multidimensional heterogeneity analysis. The conclusions are as follows. (1) Digital economy can promote carbon neutral technological innovation. (2) The mechanism test demonstrates how scientific and technological production and regional innovation potential might contribute to carbon neutral technology innovation in the digital economy. (3) Heterogeneity analysis shows that based on the three-dimensional city attributes of “location-feature-scale”, the research results show significant differences across different cities. The research conclusions provide a certain reference value for further strengthening and promoting carbon neutral technology innovation.
The Military Actions of the Kalmyk Cavalry on the Crimean Khanate Territory in 1675
Authors:   Kalmyk Scientific Center of the RAS, Tepkeev Vladimir T.
Published: February 2025

Introduction. The article examines the circumstances of the participation of the Kalmyk cavalry in the Crimean campaign of 1675. The purpose of the study is to introduce new sources on the history of military affairs of the Kalmyks in the scientific circulation, as well as on the history of the Russian-Kalmyk relations of the 17th century, namely, the participation of the Kalmyk cavalry in the Crimean campaign of Kaspulat Mutzalovich Cherkassky in 1675. The main material for this research was the materials of the Collection 115 (“The Kabardian Affairs”) in the Russian State Archive of Ancient Acts. Results. The article consistently shows the mobilization processes of the Russian-Kalmyk army, published eyewitness' information about the fighting of the Kalmyk cavalry on the Crimean Khanate territory in September 1675. Conclusions. The Crimean campaign of Kaspulat Cherkassky in 1675 did not radically change the situation in the confrontation between Moscow and the Crimea, but made the great military and political effect, since this was the first time when “sovereign military men” with the support of Kalmyks and Zaporozhye Cossacks reached the Crimean peninsula and inflicted tangible material and human damage on the enemy. Kalmyks and Zaporozhian Cossacks with marching artillery were the main striking force of the combined army; the Crimean Khanate was vulnerable to attacks by mobile well-armed cavalry. But the unsuccessful mobilization of the Russian army, the absence of mass light cavalry in the Russian army did not allow organizing a full-fledged military campaign on the Crimea territory.
On the Colophon to “Mani-kambum” Сompiled by Zaya Pandita Namkhai Gyatso (on the problem of comparative textological analysis of the manuscript and printed texts of the Mongolian translation)
Authors:   Kalmyk Scientific Center of the RAS, Muzraeva Delyash N. , Tushinov Bair L. ,   Kalmyk Scientific Center of the RAS
Published: February 2025

Introduction. The article examines the colophon to the Mongolian translation of the major Tibetan monument of Buddhist literature, Mani-kambum, made by the famous Oirat Buddhist figure Zaya Pandita Namkhai Gyatso in 1643–1644. The colophon is written in the style of traditional Mongolian versification using initial alliteration. Materials and methods. The material for the analysis was a woodcut edition and a handwritten text of the colophon to the Mongolian translation of “Mani-kambum” made by Zaya Pandita in 1643–1644. The work uses traditional methods of textual analysis. Results. A comparative textual analysis of the contents of the Zaya Pandita colophon has been carried out based on the woodcut edition in the Mongolian language in the collection “Yum-chenmo” and the handwritten version in the Mongolian language presented in the book comp. by Luvsanbaldan. The use of the handwritten version of the colophon for text comparison was dictated by the peculiarities of printing the Beijing woodcut in Mongolian with the characteristic absence of some diacritics in it, the substitution of individual graphemes, and their indistinct display. As a result, the fragments of the text that were omitted in the handwritten colophon or written down with errors were restored, and at the same time, the correct spelling of a number of words in the woodcut, printed with errors, was established. Thus, one of the key points that needs to be taken into account in the work on compiling and clarifying transliterations of the Tibetan-Oirat corpus texts has been confirmed, namely, the use of not only woodcuts of Zaya Pandita’s translations in Mongolian language, but also their lists and copies. In addition, several stanzas of the colophon were considered, composed by Zaya Pandita in the tradition of the Mongolian versification, which enriches our understanding of him not only as a translator of Buddhist texts, but also as a talented writer.
Keywords: Zaya Pandita Namkhai Gyatso, translations, Mani-kambum, Mongolian language, colophon, textual criticism
Latin-Russian-Kalmyk Dictionary by Adrian Sokolov (1769–1771): General Description and Some Remarks on Its Grapho-phonetic Features
Authors:   Kalmyk Scientific Center of the RAS, Mirzaeva Saglara V.
Published: February 2025

Introduction. Lexicographic sources are of special value in the studies on the history of any language. As for Kalmyk language, the earliest sources of such kind dating back to the second half of the 18th century are an anonymous Russian-Kalmyk dictionary published by Kalmyk researchers in 2014 and Latin-Russian-Kalmyk dictionary by Adrian Sokolov (1769–1771), which has yet to be introduced into scientific circulation. This paper aims to provide a general description of A. Sokolov's dictionary and to analyze some grapho-phonetic features of the Kalmyk language of the second half of the 18th century. The study is based on “Kalmükisch Vocabularium von Studenten Adrian Sokolov in den Jahren 1769, 1770 und 1771” stored in collections of National Library of Russia (St. Petersburg). The dictionary consists of 76 pages and includes 1,785 Kalmyk words. We compiled the Russian-Kalmyk part of the dictionary and added modern literary Kalmyk forms, after that the dictionary materials were uploaded to Lingvodoc platform to provide comparative analysis with Proto-Mongolic and contemporary literary Kalmyk forms. Results. The particular value of this dictionary is that it contains an author's Cyrillic transcription of Kalmyk words, made by an outside observer unfamiliar with the rules of the literary (written) language, and therefore more accurately (in our opinion) reflecting the characteristics of Kalmyk oral speech of this period. The correspondences established in the dictionary, such as e — lit. Kalm. ө (Proto-Mongolic *e), o — lit. Kalm. ɵ, ai / oi — lit. Kalm. a, i — lit. Kalm. ү, b — lit. Kalm. в, coincide with Proto-Mongolic reflexes and can be characterized as archaic features of the Kalmyk language of the second half of the 18th century. They are also found in the Kalmyk wordlists made by German scholars of the same period, such as G. F. Müller (1760–1762), P. S. Pallas (1771, 1776–1789), B. Bergman (1804–1805), and J. G. Klaproth (1831). This allows us to conclude that these linguistic features were typical for the Kalmyk language of this period as a whole, and not just for separate dialects. The innovative correspondences such as e — lit. Kalm. ɵ (Proto-Mongolic *ö), o — lit. Kalm. у, and ts — lit. Kalm. ч are also found in the abovementioned wordlists, which may indicate the fact that they were supra-dialectal. The correspondences io — lit. Kalm. ү, u — lit. Kalm. ө, u — lit. Kalm. ү are only found in B. Bergman's materials, who recorded, supposedly, Derbet dialect of the Kalmyk language. Thus, we can suggest that the dictionary by A. Sokolov also reflects the dialectal features of Derbet dialect of the Kalmyk language of the second half of 18th century.
ИССЛЕДОВАНИЕ МЕХАНИЧЕСКИХ СВОЙСТВ АМОРФНОГО ПРОВОДА Co-СПЛАВА 84КХСР ПЕРЕМЕННОГО ДИАМЕТРА МЕТОДОМ ИНСТРУМЕНТАЛЬНОГО ИНДЕНТИРОВАНИЯ
Authors: Гладких Е.В. , Султанова Г.Х. , Русаков А.А. , Усейнов А.С. , Молоканов В.В. , Крутилин А.В. , Палий Н.А.
Published: February 2025

Проведено исследование пространственного распределения механических свойств в "толстом" аморфном проводе Со-сплава 84КХСР. Конусный образец аморфного провода переменного диаметра (70–300 мкм) получен методом Улитовского-Тейлора за счет изменения скорости вытяжки в процессе получения провода. После удаления стеклянной оболочки и проведения проверки на соответствие структуры провода аморфному состоянию исследовали механические свойства образцов конусного провода диаметром 100 и 270 мкм методом инструментального индентирования. Установлено, что аморфный провод в интервале диаметров 70–300 мкм сохраняет стабильные значения твердости и модуля упругости в поперечном и продольном сечениях. Механические свойства проводов исследованных диаметров также практически не изменяются при перемещении от центра образцов к краю. Полученные данные свидетельствуют о высокой изотропности аморфной структуры провода переменного диаметра. Отмеченные более высокие значения твердости и модуля упругости в образце диаметром 270 мкм (Н = 9,8 ГПа, Е = 212 ГПа) по сравнению с образцом диаметром 100 мкм (Н = 8,6 ГПа, Е = 163 ГПа) могут быть обусловлены более интенсивным формированием кластерной структуры за счет снижения эффективной скорости охлаждения более "толстого" провода. Отмечено, что такие провода могут найти применение для изготовления новых видов медицинского инструмента.
Reordenamiento dinámico de elementos usando drag & drop en Laravel-l1 y Livewire-3
Authors: Ochoa Rodríguez José Antonio
Published: February 2025

Cada categoría y subcategoría de software publicada en el “Portal de Software UNAM” es mostrada al usuario conforme al parámetro “orden_tienda”. Este valor se define previamente en el Módulo de Gestión de Categorías y Subcategorías de Software de la herramienta web en desarrollo denominada “Censo TIC”. Durante el desarrollo de dicho módulo, se implementó un control de interfaz de usuario (widget) que, con sólo arrastrar y soltar elementos de una lista con el puntero del ratón (widget drag & drop), permite actualizar de manera automática el valor de “orden_tienda” dentro de la base de datos; Esto resultó en una interfaz interactiva, fácil de usar y eficiente, que brinda la posibilidad de una menor cantidad de clics, un menor desplazamiento entre distintas pantallas para obtener datos y visualizar toda la información relacionada entre sí de cada categoría y sus subcategorías. El empleo de este tipo de controles permite una mejor experiencia de usuario (UX), enfocada en todo momento en la facilidad de uso, la eficiencia, la utilidad, la satisfacción y la emoción que el usuario experimenta durante la interacción con la interfaz web.
Effect of Graphene Oxide in Cement Mortar and its Strengthening Mechanism
Authors: Nemade P. D.
Published: February 2025

In the present study, the effect of water-dispersed powder Graphene Oxide (GO) nanoparticles on cement mortar and
its mechanical Strength after 3, 7 and 28 days of Curing is analysed. These properties were studied by adding 0.00 w/w% ,0.03
w/w%,0.05 w/w%,0.07 w/w% of cement to Obtain Compressive strength and tensile strength of cement mortar. It observed that
for 0.03% w/w of cement addition increase in compressive strength is 23.07%, for 0.05% w/w of cement addition increase in
compressive strength is 35.59%, and for 0.07% w/w of cement addition increase in compressive strength is 31.52% after 28 Days
of curing.
Tensile strength analysis for 0.03% w/w of cement addition increase in Tensile strength is 4.46%, for 0.05% w/w of cement
addition increase in Tensile strength is 34.70%, that for 0.07% w/w of cement addition increase in Tensile strength is 37.45%
after 28 Days of curing. By the addition of different proportions of graphene oxide, the compressive strength increases till the
addition of 0.05 % w/w of cement slightly decreases. For tensile strength with addition of graphene oxide the tensile strength is
increased.