bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of statins on wound healing: an ally in treating the highly comorbid patient
Authors: Abu El Hawa Areeg A , Klein Doron , Bekeny Jenna C , Severin James H , Zolper Elizabeth G , Tefera Eshetu , Evans Karen K , Fan Kenneth L , Attinger Christopher E
Published: February 2022

Objective:

To identify the impact that HMG-CoA reductase inhibitors (statins) use has on wound healing outcomes in patients with comorbidities.

Method:

A retrospective chart review evaluating all new patients presenting to our tertiary wound care centre in 2013 with lower extremity wounds. Patients were divided into two groups depending on whether they took statins or not. Data on wound healing outcomes and wound/patient characteristics were collected. Primary outcomes included healing rate and progression to complete wound healing. Patients were excluded if they had incomplete data or were lost to follow-up before healing status could be confirmed.

Results:

A total of 194 patients met the inclusion criteria and were allocated to either the statin group (n=89) or to the non-statin group (n=105). Median initial wound size was 0.6cm3 (Interquartile range (IQR): 0.15–2.4) (p=0.684). In the statin group, 54 (60.6%) patients progressed to complete wound healing compared with 47 (44.7%) in the non-statin group (p=0.027). Median rate of wound healing was 6.7×10-3cm3/day (IQR: 1.5×10-3–2.6×10-2) compared with 3.8×10-3cm3/day (IQR: 1.7×10-3–1.3×10-2) in the non-statin group (p=0.773). Increased age and a higher number of comorbidities were reported in the statin group (p<0.001), respectively). A total of seven patients required amputation: five patients in the statin group and two patients in the non-statin group (p=0.250).

Conclusion:

This study revealed increased progression to wound healing in patients who were taking statins. The influence of statins on wound healing is promising, but future trials are needed to justify use of this medication class independent of cardiovascular benefit and exclusively for wound healing.
Translating Teamwork into School Effectiveness: A Systematic Review of Two Decades of Research
Authors: Freedman Irith , Somech Anit
Published: February 2022

Over the last two decades, research has reached the conclusion that educator teamwork is necessary to ensure the achievement of school goals. No attempts, however, have been made to provide integrative evidence regarding its contribution to school effectiveness. To fill this void, the authors review two decades of professional team research in the context of schools. Specifically, the article has two objectives: (1) To review the existing conceptualizations of the terms 'team' and 'teamwork' in the school context; (2) To provide a systematic review of the impact of teamwork on school effectiveness. The systematic search resulted in 23 papers reporting three non-empirical and 20 empirical studies. The results of the review revealed a lack of agreement concerning the conceptualization of the terms 'team' and 'teamwork', which may affect comparability among studies. Furthermore, no comprehensive picture emerges regarding the consequences of teamwork for the individual teacher, the team, or the school as a whole. Indeed, studies refer to a wide range of variables within different contexts and configurations. This review contributes several important insights that may set the agenda for the next wave of research on teamwork in schools.
Diagnostic Challenges of Acute Eosinophilic Pneumonia Post Naltrexone Injection Presenting During The COVID-19 Pandemic
Authors:   SSM Health, Mount Vernon, IL USA, Breuer Michelle , Ali Abdulmonam
Published: February 2022

No abstract available. Article truncated after 150 words. Introduction Acute eosinophilic pneumonia (AEP) is a rare respiratory illness that may present with nonspecific symptoms ranging in severity from cough and dyspnea to potentially fatal acute respiratory distress syndrome. Although the exact etiology of AEP is unknown, it is thought to be a hypersensitivity reaction that can be idiopathic or caused by various infections, inhalation exposures, and medications (1). Here we present a rare case of AEP secondary to injectable naltrexone. Case Presentation A 45-year-old Caucasian male with a history of alcohol use disorder presented to the emergency room with a 3-day history of progressively worsening dyspnea and dry cough. The patient was a lifelong non-smoker with an unremarkable past medical history aside from alcohol abuse and obesity (BMI 41.64 kg/m²). He denied fever or chills, orthopnea, chest pain, or symptoms suggestive of paroxysmal nocturnal dyspnea. He also denied any recent sick contacts, including exposure to COVID-19. Relevant history …
Using Forum Theatre to mobilise knowledge and improve NHS care: the Enhancing Post-injury Psychological Intervention and Care (EPPIC) study
Authors: Beckett Kate , Deave Toity , McBride Tony , le May Andrée , Gabbay John , Kapoulas Urszula , Long Adele , Warburton Georgie , Wogan Celia , Cox Lee , Thompson Julian , Spencer Frank , Kendrick Denise
Published: February 2022

Background:

Evidence regarding the impact of psychological problems on recovery from injury has limited influence on practice. Mindlines show effective practice requires diverse knowledge which is generally socially transmitted.

Aims and objectives:

Develop and test a method blending patient, practitioner, and research evidence and using Forum Theatre to enable key stakeholders to interact with it.

Assess this methods; impact on contributing individuals/groups; on behaviour, practice, and research; mechanisms enabling these changes to occur.

Methods:

Stage-1: captured patient (n=53), practitioner (n=62), and research/expert (n=3) evidence using interviews, focus groups, literature review; combined these strands using framework analysis and conveyed them in a play. Stage-2: patients (n=32), carers (n=3), practitioners (n=31), and researchers (n=16) attended Forum Theatre workshops where they shared experiences, watched the play, re-enacted elements, and co-produced service improvements. Stage-3: used the Social Impact Framework to analyse study outcome data and establish what changed, how and why.

Findings:

This approach enhanced individuals’/group knowledge of post-injury psychopathology, confidence in their knowledge, mutual understanding, creativity, attitudes towards knowledge mobilisation, and research. These cognitive, attitudinal, and relational impacts led to multilevel changes in behaviour, practice, and research. Four key mechanisms enabled this research to occur and create impact: diverse knowledge, drama/storytelling, social interaction, actively altering outcomes.

Discussion and conclusions:

Discourse about poor uptake of scientific evidence focuses on methods to aid translation and implementation; this study shows how mindlines can reframe this ‘problem’ and inform impactful research.

EPPIC demonstrated how productive interaction between diverse stakeholders using creative means bridges gaps between evidence, knowledge, and action.
MAFFNet: real-time multi-level attention feature fusion network with RGB-D semantic segmentation for autonomous driving
Authors: Lv Tongfei , Zhang Yu , Luo Lin , Gao Xiaorong
Published: February 2022

Compared with RGB semantic segmentation, RGB-D semantic segmentation can combine the geometric depth information to effectively improve the segmentation accuracy. Considering the application of RGB-D semantic segmentation in autonomous driving, we design a real-time semantic segmentation network, that is, MAFFNet, which can effectively extract depth features and combine the complementary information in RGB and depth. We also design a multi-level attention feature fusion module that can excavate the available context information of RGB and depth features. At the same time, its inference speed can also meet the demands of autonomous driving. Experiments show that our network achieves excellent performance of 74.4% mIoU and an inference speed of 15.9 Hz at a full resolution of

2048

×

1024

on the cityscapes dataset. Using multi-source learning, we mixed the cityscapes and lost and found as the multi-dataset. Our network is also superior to previous algorithms in using the multi-dataset to detect small obstacles outside the road.
Damage thresholds of silicon-based cameras for in-band and out-of-band laser expositions
Authors: Théberge Francis , Auclair Michel , Daigle Jean-François , Pudo Dominik
Published: February 2022

The damage threshold of silicon-based cameras to laser irradiation is measured for continuous wave lasers at both in-band and out-of-band wavelengths. Clarifications about the various kinds of damage reported in the literature are also presented and explained through various tests. For increasing laser intensities, the sequence of laser effects on cameras usually starts from dazzling, to a decrease of the pixel response up to the complete neutralization of its pixel matrix. However, the intensity range for the complete sequence of these laser effects can strongly depend on the laser wavelengths and the tested cameras, particularly for out-of-band laser wavelengths. The proposed definitions of damage thresholds presented in this work offer a basis for the future comparison of results between different studies.
UV surface disinfection in a wearable drug delivery device
Authors: Zrehen Adam , Hili Uri , Weil Noam , Ben-David Ori , Yosef Andrei , Eitan Boaz
Published: February 2022

The advent of recombinant DNA technology fundamentally altered the drug discovery landscape, replacing traditional small-molecule drugs with protein and peptide-based biologics. Being susceptible to degradation via the oral route, biologics require comparatively invasive injections, most commonly by intravenous infusion (IV). Significant academic and industrial efforts are underway to replace IV transport with subcutaneous delivery by wearable infusion devices. To further complement the ease-of-use and safety of disposable infusion devices, surface disinfection of the drug container can be automated. For ease of use, the desired injector is a combination device, where the drug is inside the injector as a single solution combination device. The main obstacle of the desired solution is the inability to sterilize both injector and drug in the same chamber or using the same method (Gamma for the drug and ETO for the injector). This leads to the assembly of both drug container and injector after sterilization, resulting in at least one transition area that is not sterilized. To automate the delivery of the drug to the patient, a disinfection step before the drug delivery through the injector is required on the none-sterilized interface. As an innovative solution, the autoinjector presented here is designed with a single ultraviolet light-emitting diode (UV LED) for surface disinfection of the drug container and injector interface. In order to validate microbial disinfection similar to ethanol swabbing on the injector, a bacterial 3 or 6 log reduction needed to be demonstrated. However, the small disinfection chamber surfaces within the device are incapable of holding an initial bacterial load for demonstrating the 3 or 6 log reduction, complicating the validation method, and presenting a dilemma as to how to achieve the log reduction while producing real chamber conditions. The suggested solution in this paper is to establish a correlation model between the UV irradiance distribution within the disinfection chamber and a larger external test setup, which can hold the required bacterial load and represents a worse-case test scenario. Bacterial log reduction was subsequently performed on nine different microorganisms of low to high UV-tolerance. The procedure defined herein can be adopted for other surface or chamber disinfection studies in which the inoculation space is limited.
Machine vision system based on a coupled image segmentation algorithm for surface-defect detection of a Si3N4 bearing roller
Authors: Liao Dahai , Yin Mingshuai , Luo Hongbin , Li Jun , Wu Nanxing
Published: February 2022

Defect detection is a critical way to ensure quality for silicon-nitride-bearing rollers. To improve detection efficiency and precision for silicon-nitride-bearing roller surface defects, in this paper, a novel machine vision system for the detection of its surface defects is designed. This method combines image segmentation and wavelet fusion to extract features from an image. In turn, the features are used in a classifier based on the

K

-nearest neighbor for defect classification. The optimized image segmentation algorithm that is combined with wavelet fusion is the innovation of the proposed method. It is evaluated using different defect images acquired by the machine vision system. Our experiments show that the proposed machine vision system’s precision in anomaly detection of the silicon-nitride-bearing roller surface can achieve 98.5%; further, its classification precision of various defects is greater than 91.5%. It has resulted in a solution for the automatic identification of the silicon-nitride-bearing roller surface defects.
In-line reflected fiber sensor for simultaneous measurement of temperature and liquid level based on tapered few-mode fiber
Authors: Li Yichun , Song Zhuo , Pan Jiao , Lu Hanglin , Hu Junhui
Published: February 2022

An in-line reflective dual-parameters fiber-optic sensor is proposed in this work, whereas it is experimentally verified by measuring both the liquid level and the local temperature distribution simultaneously. The proposed sensor configuration comprises a single-mode fiber (SMF), a tapered few-mode fiber (TFMF), as well as a silver-coated capillary tube. The extracted experimental results indicate that the liquid level only affects the power of the resonant dips, while having little impact on the wavelength. On the other hand, both the wavelength and the power of the resonant dips vary with the temperature change. Therefore, the simultaneous measurement of the liquid level and temperature can be realized according to the different responses of the resonant dips to the liquid level and temperature. The obtained liquid level and temperature sensitivities can reach the values of 0.106 dB/mm and 0.029 dB/°C, 35 pm/°C, respectively. The sensor exhibits the advantages of high stability and low cost, the demodulation relates on only one wavelength which can shorten the scanning wavelength range during measurement. The proposed sensor can be potentially applied where accurate and simultaneous measurements of both temperature and liquid level are required.
Self-calibration for Mueller polarimeters based on DoFP polarization imagers
Authors: Li Xiaobo , Goudail François , Chen Shih-Chi
Published: February 2022

Mueller polarimeters (MPs) based on division of focal plane (DoFP) polarization imagers can achieve fast measurements and significantly improve the effectiveness of Mueller polarimetry. In this Letter, we demonstrate a unique property of the DoFP sensor-based MPs: they can be calibrated without any extra polarizing reference element. We describe a self-calibration method that only requires six image acquisitions; based on our analysis, the calibration accuracy is only limited by the noise.
Evidence for the emergence of β-trefoils by ‘Peptide Budding’ from an IgG-like β-sandwich
Authors: Longo Liam M. , Kolodny Rachel , McGlynn Shawn E.
Published: February 2022

As sequence and structure comparison algorithms gain sensitivity, the intrinsic interconnectedness of the protein universe has become increasingly apparent. Despite this general trend, β-trefoils have emerged as an uncommon counterexample: They are an isolated protein lineage for which few, if any, sequence or structure associations to other lineages have been identified. If β-trefoils are, in fact, remote islands in sequence-structure space, it implies that the oligomerizing peptide that founded the β-trefoil lineage itself arose de novo. To better understand β-trefoil evolution, and to probe the limits of fragment sharing across the protein universe, we identified both ‘β-trefoil bridging themes’ (evolutionarily-related sequence segments) and ‘β-trefoil-like motifs’ (structure motifs with a hallmark feature of the β-trefoil architecture) in multiple, ostensibly unrelated, protein lineages. The success of the present approach stems, in part, from considering β-trefoil sequence segments or structure motifs rather than the β-trefoil architecture as a whole, as has been done previously. The newly uncovered inter-lineage connections presented here suggest a novel hypothesis about the origins of the β-trefoil fold itself–namely, that it is a derived fold formed by ‘budding’ from an Immunoglobulin-like β-sandwich protein. These results demonstrate how the evolution of a folded domain from a peptide need not be a signature of antiquity and underpin an emerging truth: few protein lineages escape nature’s sewing table.
Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling
Authors: Diamant Nathaniel , Reinertsen Erik , Song Steven , Aguirre Aaron D. , Stultz Collin M. , Batra Puneet
Published: February 2022

Supervised machine learning applications in health care are often limited due to a scarcity of labeled training data. To mitigate the effect of small sample size, we introduce a pre-training approach,PatientContrastiveLearning ofRepresentations (PCLR), which creates latent representations of electrocardiograms (ECGs) from a large number of unlabeled examples using contrastive learning. The resulting representations are expressive, performant, and practical across a wide spectrum of clinical tasks. We develop PCLR using a large health care system with over 3.2 million 12-lead ECGs and demonstrate that training linear models on PCLR representations achieves a 51% performance increase, on average, over six training set sizes and four tasks (sex classification, age regression, and the detection of left ventricular hypertrophy and atrial fibrillation), relative to training neural network models from scratch. We also compared PCLR to three other ECG pre-training approaches (supervised pre-training, unsupervised pre-training with an autoencoder, and pre-training using a contrastive multi ECG-segment approach), and show significant performance benefits in three out of four tasks. We found an average performance benefit of 47% over the other models and an average of a 9% performance benefit compared to best model for each task. We release PCLR to enable others to extract ECG representations athttps://github.com/broadinstitute/ml4h/tree/master/model_zoo/PCLR.
Shape analysis of gamma rhythm supports a superlinear inhibitory regime in an inhibition-stabilized network
Authors: Krishnakumaran R , Raees Mohammed , Ray Supratim
Published: February 2022

Visual inspection of stimulus-induced gamma oscillations (30–70 Hz) often reveals a non-sinusoidal shape. Such distortions are a hallmark of non-linear systems and are also observed in mean-field models of gamma oscillations. A thorough characterization of the shape of the gamma cycle can therefore provide additional constraints on the operating regime of such models. However, the gamma waveform has not been quantitatively characterized, partially because the first harmonic of gamma, which arises because of the non-sinusoidal nature of the signal, is typically weak and gets masked due to a broadband increase in power related to spiking. To address this, we recorded local field potential (LFP) from the primary visual cortex (V1) of two awake female macaques while presenting full-field gratings or iso-luminant chromatic hues that produced huge gamma oscillations with prominent peaks at harmonic frequencies in the power spectra. We found that gamma and its first harmonic always maintained a specific phase relationship, resulting in a distinctive shape with a sharp trough and a shallow peak. Interestingly, a Wilson-Cowan (WC) model operating in an inhibition stabilized mode could replicate this shape, but only when the inhibitory population operated in the super-linear regime, as predicted recently. However, another recently developed model of gamma that operates in a linear regime driven by stochastic noise failed to produce salient harmonics or the observed shape. Our results impose additional constraints on models that generate gamma oscillations and their operating regimes.
An ancient haplotype containing antimicrobial peptide gene variants is associated with severe fungal skin disease in Persian cats
Authors: Myers Alexandra N. , Lawhon Sara D. , Diesel Alison B. , Bradley Charles W. , Rodrigues Hoffmann Aline , Murphy William J. ,   99 Lives Cat Genome Consortium
Published: February 2022

Dermatophytosis, also known as ringworm, is a contagious fungal skin disease affecting humans and animals worldwide. Persian cats exhibit severe forms of the disease more commonly than other breeds of cat, including other long-haired breeds. Certain types of severe dermatophytosis in humans are reportedly caused by monogenic inborn errors of immunity. The goal of this study was to identify genetic variants in Persian cats contributing to the phenotype of severe dermatophytosis. Whole-genome sequencing of case and control Persian cats followed by a genome-wide association study identified a highly divergent, disease-associated haplotype on chromosome F1 containing the S100 family of genes. S100 calcium binding protein A9 (S100A9), which encodes a subunit of the antimicrobial heterodimer known as calprotectin, contained 13 nonsynonymous variants between cases and controls. Evolutionary analysis of S100A9 haplotypes comparing cases, controls, and wild felids suggested the divergent disease-associated haplotype was likely introgressed into the domestic cat lineage and maintained via balancing selection. We demonstrated marked upregulation of calprotectin expression in the feline epidermis during dermatophytosis, suggesting involvement in disease pathogenesis. Given this divergent allele has been maintained in domestic cat and wildcat populations, this haplotype may have beneficial effects against other pathogens. The pathogen specificity of this altered protein should be investigated before attempting to reduce the allele frequency in the Persian cat breed. Further work is needed to clarify if severe Persian dermatophytosis is a monogenic disease or if hidden disease-susceptibility loci remain to be discovered. Consideration should be given to engineering antimicrobial peptides such as calprotectin for topical treatment of dermatophytosis in humans and animals.
Comparison of clinical profiles and care for patients with incident versus recurrent acute coronary syndromes in France: Data from the MONICA registries
Authors: Machta Suzanne , Gauthier Victoria , Ferrières Jean , Montaye Michèle , Huo Yung Kai Samantha , Gbokou Stefy , Biasch Katia , Moitry Marie , Amouyel Philippe , Dallongeville Jean , Meirhaeghe Aline
Published: February 2022

Background

Recurrence is common after an acute coronary syndrome (ACS). In order to better assess the prognosis for patients with ACS, we compared clinical profiles, treatments, and case fatality rates for incident vs. recurrent ACS.

Methods

We enrolled 1,459 men and women (age: 35–74) living in three geographical areas covered by French MONICA registries and who had been admitted to hospital for an ACS in 2015/2016. We recorded and compared the clinical characteristics and medical care for patients with an incident vs. a recurrent ACS.

Results

Overall, 431 (30%) had a recurrent ACS. Relative to patients with an incident ACS, patients with recurrence were older (p<0.0001), had a greater frequency of NSTEMI or UA (p<0.0001), were less likely to show typical symptoms (p = 0.045), were more likely to have an altered LVEF (p<0.0001) and co-morbidities. Angioplasty was less frequently performed among patients with recurrent than incident NSTEMI (p<0.05). There were no intergroup differences in the prescription of the recommended secondary prevention measures upon hospital discharge, except for functional rehabilitation more frequently prescribed among incident patients (p<0.0001). Although the crude 1-year mortality rate was higher for recurrent cases (14%) than for incident cases (8%) (p<0.05), this difference was no longer significant after adjustment for age, sex, region, diagnosis category and LVEF.

Conclusion

Compared with incident patients, recurrent cases were more likely to have co-morbidities and to have suboptimal treatments prior to hospital stay, reinforcing the need for secondary prevention.
Serum miR-192-5p levels predict the efficacy of pegylated interferon therapy for chronic hepatitis B
Authors: Nagura Yoshihito , Matsuura Kentaro , Iio Etsuko , Fujita Koji , Inoue Takako , Matsumoto Akihiro , Tanaka Eiji , Nishiguchi Shuhei , Kang Jong-Hon , Matsui Takeshi , Enomoto Masaru , Ikeda Hiroki , Watanabe Tsunamasa , Okuse Chiaki , Tsuge Masataka , Atsukawa Masanori , Tateyama Masakuni , Kataoka Hiromi , Tanaka Yasuhito
Published: February 2022

We examined the association between serum miRNA (-192-5p, -122-3p, -320a and -6126-5p) levels and the efficacy of pegylated interferon (Peg-IFN) monotherapy for chronic hepatitis B (CHB) patients. We enrolled 61 CHB patients treated with Peg-IFNα-2a weekly for 48 weeks, of whom 12 had a virological response (VR) and 49 did not VR (non-VR). A VR was defined as HBV DNA < 2,000 IU/ml, hepatitis B e antigen (HBeAg)-negative, and nucleos(t)ide analogue free at 48 weeks after the end of treatment. The non-VR group showed a significantly higher HBeAg-positivity rate, ALT, HBV DNA, and serum miR-192-5p levels at baseline (P = 0.024, P = 0.020, P = 0.007, P = 0.021, respectively). Serum miR-192-5p levels at 24-weeks after the start of treatment were also significantly higher in the non-VR than the VR group (P = 0.011). Multivariate logistic regression analysis for predicting VR showed that miR-192-5p level at baseline was an independent factor (Odds 4.5, P = 0.041). Serum miR-192-5p levels were significantly correlated with the levels of HBV DNA, hepatitis B core-related antigen, and hepatitis B surface antigen (r = 0.484, 0.384 and 0.759, respectively). The serum miR-192-5p level was useful as a biomarker for the therapeutic efficacy of Peg-IFN in CHB treatment.
Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses
Authors: Musaigwa Fungai , Kamdem Severin Donald , Mpotje Thabo , Mosala Paballo , Abdel Aziz Nada , Herbert De’Broski R. , Brombacher Frank , Nono Justin Komguep
Published: February 2022

Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic schistosomiasis on the sustainability of vaccine-induced immunity in both children living in endemic areas and experimental infections in mice. Data show that chronicSchistosoma mansoniinfection impaired the persistence of vaccine specific antibody responses in poliovirus-vaccinated humans and mice. Mechanistically, schistosomiasis primarily fostered plasmablast and plasma cell death in the bone marrow and removal of parasites following praziquantel treatment reversed the observed cell death and partially restored vaccine-induced memory responses associated with increased serum anti-polio antibody responses. Our findings strongly suggest a previously unrecognized mechanism to explain how chronic schistosomiasis interferes with an otherwise effective vaccine regimen and further advocates for therapeutic intervention strategies that reduce schistosomiasis burden in endemic areas prior to vaccination.
SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants
Authors: Panikkar Archana , Lineburg Katie E. , Raju Jyothy , Chew Keng Yih , Ambalathingal George R. , Rehan Sweera , Swaminathan Srividhya , Crooks Pauline , Le Texier Laetitia , Beagley Leone , Best Shannon , Solomon Matthew , Matthews Katherine K. , Srihari Sriganesh , Neller Michelle A. , Short Kirsty R. , Khanna Rajiv , Smith Corey
Published: February 2022

Adoptive T-cell immunotherapy has provided promising results in the treatment of viral complications in humans, particularly in the context of immunocompromised patients who have exhausted all other clinical options. The capacity to expand T cells from healthy immune individuals is providing a new approach to anti-viral immunotherapy, offering rapid off-the-shelf treatment with tailor-made human leukocyte antigen (HLA)-matched T cells. While most of this research has focused on the treatment of latent viral infections, emerging evidence that SARS-CoV-2-specific T cells play an important role in protection against COVID-19 suggests that the transfer of HLA-matched allogeneic off-the-shelf virus-specific T cells could provide a treatment option for patients with active COVID-19 or at risk of developing COVID-19. We initially screened 60 convalescent individuals and based on HLA typing and T-cell response profile, 12 individuals were selected for the development of a SARS-CoV-2-specific T-cell bank. We demonstrate that these T cells are specific for up to four SARS-CoV-2 antigens presented by a broad range of both HLA class I and class II alleles. These T cells show consistent functional and phenotypic properties, display cytotoxic potential against HLA-matched targets and can recognize HLA-matched cells infected with different SARS-CoV-2 variants. These observations demonstrate a robust approach for the production of SARS-CoV-2-specific T cells and provide the impetus for the development of a T-cell repository for clinical assessment.
Antimicrobial, Cytotoxicity and Molecular Docking Study of
New Quinoline Schiff Base and its Metal(II) Complexes
Authors: Vibhute B.T. , Aghav B.D. , More B.P. , Bellamkonda R.O. , Patil S.K.
Published: February 2022

A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin-
3-carbaldehyde and 4-methylbenzene sulfonohydrazide. Synthesized Schiff base further utilized for
the formation of stable metal complexes with Cu(II), Ni(II), Co(II) and Cd(II) metal salts and
characterized by different spectroscopic techniques i.e. 1H NMR, 13C NMR, FT-IR, UV-visible, ESR,
MASS and TGA. The low molar conductance values indicate that synthesized metal(II) complexes
were non-electrolytes. The magnetic moment value indicates that Cu(II), Ni(II) and Co(II) complexes
were paramagnetic. Further, these compounds were screened for inhibition activity against four bacterial
strains, three fungal strains and cytotoxicity against the A-549 and MCF-7 cell lines by using the MTT
method. Among the synthesized complexes, metal complexes exhibited excellent anticancer activity
against the human lung cancer cell line (A-549). Schiff base and its Cd(II) complex showed good
antibacterial activity. Furthermore, molecular docking study shows the significant binding affinity of
metal complexes with tubulin protein. Present study proposed that all the synthesized Schiff base
metal(II) complexes have excellent biological activity and could be act as potential anticancer agents.
Growth Mechanism, Structural and Photoelectrochemical Study of Zinc Tellurium Thin Film
Authors: Rathod Kisan C. , Sanadi Kallappa R. , Kamble Pradip D. , Kamble Ganesh S. , Gaur Muddsar L. , Garadkar Kalyanrao M.
Published: February 2022

Chalcogenides II-VI group of crystalline material zinc tellurium thin films have been synthesized by
chemical bath deposition (CBD) method in which glass substrates have been used for deposition
technique in presence of triethanolamine solution. The as-synthesized films were characterization by
X-ray diffraction scanning electron microscopy (XRD), optical spectroscopy and thermoelectric
techniques. The deposited material was orthorhombic in shape. The 2.01 eV is the optical band gap
energy of the sample and the electrical conductivity of the thin film was originating in the order of 10-8
(Ω cm)-1, which showed n-type thermoelectrical conductivity. The solar cell can be represented as a
n-ZnTe|NaI (0.1M) + I2 (0.1M)|C(graphite). The solar efficiency of the cell was found to be 1.03%.
Synthesis, Characterization and Biological Screening of Novel Imidazolylpyrazole Scaffolds
Authors: SHARMA JYOTSNA , TULI HARDEEP SINGH , KINGER MAYANK , PAL RAM , ABBAS ZAHOOR , KUMAR MANOJ
Published: February 2022

A novel series of 3-(4-aryl)-4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phenyl-1H-pyrazole was synthesized by employing the well-known
Debus-Radziszewski reaction. Structures of all the newly synthesized compounds have been characterized by various spectroscopic
techniques viz. FTIR, 1H and 13C NMR, LC-MS and elemental analysis. All these compounds were also screened for antimicrobial
potential against bacterial strains of S. aureus, K. pneumoniae and fungal strains of A. niger and T. rubrum.
Mitigation and Chemistry of Indoor Air Pollutants in Urban and Rural
Environments of India: A Review of Contemporary Advances
Authors: DWIVEDI SAMRIDHI , TEWARI AYUSHI , DWIVEDI SRISHTI , ARIF SAIMA , KHAN TAHMEENA , LAWRENCE ALFRED J.
Published: February 2022

Globally people devote approximately 90% of their time indoors either in their house or office or institution, etc. Together with the
dispersion of outdoor air pollutants, toxins are produced in indoor atmosphere owing to various actions such as heating, cooking, cooling
and emissions from building materials. Hence, the indoor air quality (IAQ) influences human well-being and efficiency. Even though
indoor air quality (IAQ) research has been done from various outlooks, there is still an absence of inclusive assessment of peer reviewed
IAQ studies, which precisely covers the IAQ in rural and urban environment helping to recognize the sources and consequences in both
the environment, respectively. Therefore, this review article of scientific studies offers a broad spectrum of pollutants identified in both
rural and urban indoor environments in context to India, highlighting the technical interventions, modelling techniques and remedies such
as HEPA filters, carbon filters, bioremediation etc. in course of improving IAQ. This review also elucidates the chemistry of pollutants
along with general chemical reactions between pollutants. Thus, this review paper holds the potential to help building professionals and
researchers in the field for regulating indoor air quality and generate healthy and sustainable indoor environment.
Identificação das necessidades educacionais especiais no contexto de políticas públicas
Authors: Johnson Luanna Freitas , Yaegashi Solange Franci Raimundo , Fonseca Aline Arruda Rodrigues da
Published: February 2022

O presente artigo tem como objetivo analisar o processo de identificação das necessidades educacionais especiais de estudantes com deficiência intelectual (DI) encaminhados ao Atendimento Educacional Especializado (AEE). Para tanto, recorremos à pesquisa documental, a partir de marcos legais e materiais de formação docente utilizadas pelo Ministério da Educação. A análise dos elementos evidencia lacunas quanto aos subsídios teórico metodológicos para subsidiar esse processo. Os marcos legais apontam diversas atribuições do professor, tais como: avaliação das necessidades, elaboração e execução do plano de atendimento individual, produção de materiais pedagógicos, articulação com outros setores, orientação à família e ao professor da sala regular. Por sua vez, as publicações utilizadas na formação docente não promovem sua instrumentalização. Sendo assim, o processo de identificação das necessidades do aluno precisa ser subsidiado por fundamentos teóricos e metodológicos que oportunizem a organização da educação escolar com vistas à humanização do estudante independentemente de suas condições objetivas.
Transposição didática do conceito de número irracional nas obras portuguesas de 1909 a 1963
Authors: Dias Marisa da Silva
Published: February 2022

O objetivo é apresentar o conceito de número irracional em onze obras didáticas portuguesas compreendendo o período de 1909 a 1963. Sob os princípios teóricos da transposição didática, com enfoque no saber a ensinar e da metodologia exploratória do tipo bibliográfica, os principais resultados voltados à publicidade desse saber são caracterizados por definições de número irracional como classes contíguas, em obras na década de 1910; como relação entre grandezas incomensuráveis, nas obras da década de 1930 e início da década de 1940 e como dízima infinita não periódica, nas obras das décadas de 1950 e 1960, em definitiva substituição a abordagem de classes contíguas. A sequência das explanações didáticas do conceito nas obras, em geral, parte de um caso particular de raiz quadrada de um número que não é quadrado perfeito, seguindo para uma definição, como generalização, e poucos exemplos. Exemplos de números transcendentes aparecem após 1954.
A formação continuada na perspectiva da colaboração profissional entre professores: uma revisão bibliográfica
Authors: Silva Michelly Vital da , Cericato Itale Luciane
Published: February 2022

Este artigo apresenta dados de estudo que revisou o estado da questão a respeito da formação continuada na perspectiva da colaboração profissional entre professores. O interesse pelo tema decorre de a literatura especializada apontar que a formação continuada realizada por meio de cursos, palestras e seminários tem sido insuficiente para suprir as necessidades dos professores frente aos atuais desafios da profissão, evidenciando a conveniência de se conhecer alternativas mais eficazes. Foram buscadas, a partir do descritor “formação continuada colaborativa em serviço”, pesquisas empíricas recentes produzidas nos últimos cinco anos e publicadas na base de dados da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), no Portal de Periódicos da Capes e no portal de dados científicos WorldWideScience.org. Os resultados encontrados apontam que processos de formação continuada, realizados de modo colaborativo entre os professores, promovem mudanças na prática pedagógica e contribuem para o desenvolvimento profissional docente.
KONSEP AWAL PEMBERDAYAAN MASYARAKAT OLEH ‘AISYIYAH
Authors: Sofia Adib
Published: February 2022

One of the social capital that the Indonesian nation has to conduct community empowerment since the pre-independence era until today is ‘Aisyiyah. Since its establishment in 1917, ‘Aisyiyah has owned many models of social empowerment through its movements spread throughout Indonesia and abroad. ‘Aisyiyah has also conducted the community empowerment through a media, Suara ‘Aisyiyah. The initial concept of community empowerment by ‘Aisyiyah needs to be revealed because it is the basic identification conducted by ‘Aisyiyah as a whole until today. This writing reveals two things. First, the initial concept of community empowerment by ‘Aisyiyah contained in Suara ‘Aisyiyah in the era of national movement. Second, the community empowerment sectors conducted by Suara ‘Aisyiyah in the era of national movement. As a whole this writing reveals a phenomenon that is different from a description happening in the colonial era. Generally in the pre-independence era women were described as the members of society who were uneducated, backward, and had no actions in public domain. This writing reveals that women in the pre-independence era had the concept of community empowerment complete with its sectors
Pertaruhan Keimanan Pascal dan Dampaknya pada Perilaku Beragama
Authors: Maulana Ilham
Published: February 2022

For a man, his faith would be a base of his worldview, such as his thought about what is good and evil, and also about how he should act of daily life. In the same context but with different view, philosophy explained that metaphysics is a foundation of man's thought. Include about its ethic thought. This article will explain about Pascal’s Wager, about wager of faith, as a foundation of religious behavior. With philosophical approach, it will illustrate how faith that believed by someone could influence his behavior of daily. Thus the result of this article tells that a man’s faith about God and life after death impacts for religious behavior. In contrary if someone couldn’t believe about God and life after death, it also impacts for his behavior. Both are opposed because of differences in knowledge about faith which have an impact on the value system adopt in ethics.[Bagi seorang manusia, keimanannya akan menjadi dasar dari pandangan dunianya (worldview), seperti pemikirannya mengenai apa yang dimaksud dengan baik dan buruk, dan juga mengenai bagaimana seharusnya ia bertindak di kehidupan hariannya. Dalam konteks yang sama namun berbeda pandangan, filsafat menjelaskan bahwa metafisika merupakan fondasi dari pemikiran seseorang. Termasuk tentang pemikiran etikanya. Artikel ini akan menjelaskan mengenai Pertaruhan Pascal (Pascal’s Wager), yakni tentang pertaruhan iman, sebagai fondasi dari perilaku beragama. Dengan pendekatan filsafat, artikel ini akan mengilustrasikan bagaimana iman yang dipercayai oleh seseorang bisa mempengaruhi perilaku hariannya. Jadi hasil dari artikel ini memberitahu bahwa keyakinan seseorang tentang Tuhan dan kehidupan setelah kematian berdampak pada perilaku beragama. Sebaliknya jika seseorang tidak percaya tentang Tuhan dan kehidupan setelah kematian, itu pun berdampak pada perilakunya. Keduanya berlawanan karena adanya perbedaan dalam pengetahuan mengenai iman yang memiliki dampak pada sistem nilai yang diadopsi dalam etika.]
Hasan bin Sabbah dan Gerakan Pembaharuan (Da’wah Jadidah) Syiah Isma’iliyah Abad XI Masehi
Authors: Hidayat Rahmat
Published: February 2022

This article discusses the theological renewal initiated with Hasan bin Sabbah in the teachings of Syiah Isma'iliyah after the internal conflict of the Fatimiyah Dynasty. Hasan bin Sabbah with his Assassin Sect revitalises extremely the Isma’iliyah propaganda to streghthen the charisma of Isma’iliyah in Persia. The theological renewal (da’wah jadidah) in Isma’iliyah doctrin was a manifestation of Hasan bin Sabbah’s rejection to the legitimacy of the Abbasid and Seljuq leadership and the Fatimiyah Dynasty. This research is a library research which uses historical analysis methods which include heuristics, verification, interpretation, and historiography. This research found the results (1) The existence of differences in political interests with the old Isma'iliyah tradition encouraged Hasan bin Sabbah to carry out reforms (tajdid) to break political and cultural relations with the Isma'iliyah Fatimiyah association in Egypt. (2) The reformation carried out by Hasan bin Sabbah in Isma'iliyah theology includes the teachings of ta’limiyyah, the Nizar priesthood, ‘ilm zahir dan batin in Islamic teachings, at-ta’wil al-batini, taqiyyah which constructs the extreme character of the Assassin movement, and the continuity of imam mastur.[Artikel ini bertujuan menganalisis pembaharuan ajaran Hasan bin Sabbah dalam doktrin Syiah Isma’iliyah pasca konflik internal Dinasti Fatimiyah. Hasan bin Sabbah dengan Sekte Assassinnya merevitalisasi propaganda Isma’iliyah secara ekstrim untuk memulihkan kekuatan neo-Isma’iliyah di Persia. Pembaharuan teologis (da’wah jadidah) dalam doktrin Isma’iliyah merupakan manisfetasi penolakan Hasan atas keabsahan kepemimpinan Dinasti Abbasiyah dan Saljuk serta Dinasti Fatimiyah Mesir. Penelitian ini merupakan kajian pustaka (library research) yang menggunakan metode analisis historis yang meliputi heuristik, verifikasi, interpretasi, dan historiografi. Penelitian ini mendapatkan hasil (1) Adanya perbedaan kepentingan politik dengan tradisi Isma’iliyah lama mendorong Hasan bin Sabbah melakukan pembaharuan (tajdid) untuk memutuskan hubungan politik dan kultural dengan perkumpulan Isma’iliyah Fatimiyah di Mesir. (2) Pembaharuan Hasan bin Sabbah dalam doktrin neo-Isma’iliyah meliputi ajaran ta’limiyyah, keimaman Nizar, ‘ilm zahir dan batin dalam ajaran Islam, at-ta’wil al-batini, taqiyyah yang mengkonstruksi karakter gerakan Assassin yang ekstrim, dan kontinuitas imam mastur.]
Territorio e identidad de resistencia en jóvenes del Catatumbo (Colombia), constructores de paces imperfectas
Authors: Espinel-Rubio Gladys Adriana , Feo-Ardila Diana
Published: February 2022

Este artículo explora las nociones que tienen de su territorio los y las jóvenes del Catatumbo, explicando desde allí la configuración de una identidad de resistencia y la construcción de paces imperfectas. Es una investigación cualitativa en la que a través de la cartografía social, los árboles de problemas, la escritura creativa y el filminuto, 202 personas entre los 10 y los 26 años de cuatro municipios colombianos, identificaron los riesgos, pero también las oportunidades que les brinda la región -sistemáticamente afectada por el conflicto armado, la economía extractiva y los cultivos ilícitos-, para construir su proyecto de vida desde lo identitario, la resiliencia y sus sueños, que siempre incluyen, su pervivencia en el territorio. Se concluye que los y las jóvenes están ejerciendo un poder de manera noviolenta para transformar su realidad, garantizar sus derechos y evitar su continua vulneración. Esperan tener mayor incidencia política y pública, no sólo visibilizando su situación, sino transmitiendo este discurso a las nuevas generaciones con intereses en promocionar la paz.
SYSTEMATIC REVIEW HUBUNGAN ANTARA KEPATUHAN PENGOBATAN ORAL ANTIDIABETES DAN GAGAL GINJAL PENDERITA DIABETES MELLITUS
Authors: Orbanida Firdianita Nuria , Wurjanto Moh. Arie , Udijono Ari , Setyawan Henry
Published: February 2022

Knowledge, Belief, Attitude, Drug Amount, Family Support, Physical Activity, Carbohydrate Intake and Pharmacological Therapy related to DM control with medication adherence and kidney failure in DM patients. This review aims to identify articles regarding adherence to oral antidiabetic drugs and kidney failure in DM patients. Search articles in several databases using keywords in the 2011-2020 period and gray literature. Search libraries using online databases such as MEDLINE, Proquest, Garuda Journal and Google Scholar. Review synthesis using STROBE. Sixteen research articles for review. Taking medication and kidney failure in DM patients are related to the compliance of DM patients. Non-compliance with DM patients through DM control behavior (physical activity, carbohydrate intake, control of blood glucose levels) and awareness for treatment is still low. Motivation, family support and a good relationship between doctors and patients can have an influence on the obedient behavior of DM patients.
DESAIN KESIAPSIAGAAN TANGGAP DARURAT KEBAKARAN DI PASAR TRADISIONAL BOJA KABUPATEN KENDAL 2021
Authors: Adhiatma Pramudya Fahry , Kurniawan Bina , Ekawati Ekawati
Published: February 2022

Boja Market is the main market in Boja District, Kendal, Central Java. Products from agriculture (fruits and vegetables) as well as industrial goods (clothing and electronics) can be sold in this market. Boja Market experienced a fire accident in 2007. As a result, traders suffered losses in the form of burned goods and trading activities in the market were hampered because traders lost their places to trade. Therefore, it is necessary to do fire prevention efforts to prevent fires from occurring. The purpose of this study was to design fire prevention efforts in the Boja Traditional Market, Kendal Regency based on the standard. This research is qualitative descriptive research. The research uses in-depth interviews and field observations, then the existing data is compared with standards for further analysis and design processes. The variable in this study is fire prevention efforts, includes: fire management and fire fighting facilities. The results of the study carried out a comparative analysis with applicable regulatory standards. The proposed design for supporting fire prevention efforts include: organizational structure for fire prevention, standard operating procedures for fire prevention and design of fire facilities layout plans. Traditional Boja Market, Kendal Regency, has carried out fire prevention efforts but has not been maximized so that researchers provide suggestions in the form of designs that are expected to be applied in the market.