bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Post-UV/Ozone Treatment of Ultrasonic-Sprayed Zirconium Oxide Dielectric Films for a Low-Temperature Oxide Thin Film Transistor
Authors: Oluwabi Abayomi Titilope , Gaspar Diana , Katerski Atanas , Mere Arvo , Krunks Malle , Pereira Luis , Oja Acik Ilona
Published: December 2019

Solution-processed metal oxides require a great deal of thermal budget in order to achieve the desired film properties. Here, we show that the deposition temperature of sprayed zirconium oxide (ZrOx) thin film can be lowered by exposing the film surface to an ultraviolet (UV) ozone treatment at room temperature. Atomic force microscopy reveals a smooth and uniform film with the root mean square roughness reduced from ~ 0.63 nm (UVO-O) to ~ 0.28 nm (UVO-120) in the UV–ozone treated ZrOx films. X-ray photoelectron spectroscopy analysis indicates the formation of a Zr–O network on the surface film, and oxygen vacancy is reduced in the ZrOx lattice by increasing the UV–ozone treatment time. The leakage current density in Al/ZrOx/p-Si structure was reduced by three orders of magnitude by increasing the UV-ozone exposure time, while the capacitance was in the range 290–266 nF/cm2, corresponding to a relative permittivity (k) in the range 5.8–6.6 at 1 kHz. An indium gallium zinc oxide (IGZO)-based thin film transistor, employing a UV-treated ZrOx gate dielectric deposited at 200 °C, exhibits negligible hysteresis, an Ion/Ioff ratio of 104, a saturation mobility of 8.4 cm2 V−1S−1, a subthreshold slope of 0.21 V.dec−1, and a Von of 0.02 V. These results demonstrate the potentiality of low-temperature sprayed amorphous ZrOx to be applied as a dielectric in flexible and low-power-consumption oxide electronics.
Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy
Authors: Nagi Jaspreet Singh , Skorenko Kenneth , Bernier William , Jones Wayne E. , Doiron Amber L.
Published: December 2019

Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.
High Temperature Interaction of Si-B Alloys with Graphite Crucible in Thermal Energy Storage Systems
Authors: Jiao Jianmeng , Safarian Jafar , Grorud Bettina , Tangstad Merete
Published: December 2019

Si-B alloys are proposed as a potential phase change material (PCM) in the novel high temperature thermal energy storage systems. For successfully introducing the new PCM, the selection of proper refractory material in the PCM container is vital. At present, graphite is chosen as a potential refractory material for the PCM container, due to its high temperature stability, low thermal expansion, and high thermal conductivity. The Si-B alloys and the high-temperature interaction with graphite are hence studied. The phase formation in the Si-B alloys and the interaction with graphite at B content of 2–11 mass % and temperatures of 1450–1750 °C were investigated. Carbides were observed at the interface between the solidified alloys and the graphite. A single SiC layer was produced at B content of 2 and 3.25 mass %. Otherwise, SiC and B4C layers were generated at B content higher than 5 mass %. In the Si-B-C system, the phase formation is dependent on the B content. Moreover, the equilibrium B content is calculated to be 3.66 mass % in the molten Si-B alloys at 1450 °C in equilibrium with SiC and B4C, based on the experimental results. In this regard, the eutectic alloy (3.25 mass % B) is recommended to be used as the new PCM in the graphite container, due to that it produces simple phases and also because it is expected not to deplete any B to the B4C layer.
Nano-Scaled Creep Response of TiAlV Low Density Medium Entropy Alloy at Elevated Temperatures
Authors: Zhang Xiangkai , Ye Hanting , Huang Jacob C. , Liu Taiyou , Lin Pinhung , Wu Yaocheng , Tsai Mintsang , Liao Yuchin , Jang Jason S. C.
Published: December 2019

A low density, medium entropy alloy (LD-MEA) Ti33Al33V34 (4.44 g/cm3) was successfully developed. The microstructure was found to be composed of a disordered body-centered-cubic (BCC) matrix and minor ordered B2 precipitates based on transmission electron microscopy characterization. Equilibrium and non-equilibrium modeling, simulated using the Calphad approach, were applied to predict the phase constituent. Creep behavior of {110} grains at elevated temperatures was investigated by nanoindentation and the results were compared with Cantor alloy and Ti-6Al-4V alloy. Dislocation creep was found to be the dominant mechanism. The decreasing trend of hardness in {110} grains of BCC TiAlV is different from that in {111} grains of face-centered-cubic (FCC) Cantor alloy due to the different temperature-dependence of Peierls stress in these two lattice structures. The activation energy value of {110} grains was lower than that of {111} grains in FCC Cantor alloy because of the denser atomic stacking in FCC alloys. Compared with conventional Ti-6Al-4V alloy, TiAlV possesses considerably higher hardness and specific strength (63% higher), 83% lower creep displacement at room temperature, and 50% lower creep strain rate over the temperature range from 500 to 600 °C under the similar 1150 MPa stress, indicating a promising substitution for Ti-6Al-4V alloy as structural materials.
Long-Term Stability of Ferroelectret Energy Harvesters
Authors: Kayaharman Muhammed , Das Taylan , Seviora Gregory , Saritas Resul , Abdel-Rahman Eihab , Yavuz Mustafa
Published: December 2019

Cellular polypropylene (PP) has been recently used in energy harvesting applications. In this work, we investigate its viability and long-term stability under various operating conditions. Specifically, the effect of constant stress and stress cycling on output power and long-term stability of ferroelectret energy harvesters is analyzed. Our findings show that after 112 days constant stress significantly increases the piezoelectric charge constant d 33 and output power from 0.51 μW for a stress-free harvester to 2.71 μW. It also increases the harvester center frequency from 450 to 700 Hz and decreases its optimal resistance from 7 to 5.5 M Ω .
Numerical Study on Thermodynamic Behavior during Selective Laser Melting of 24CrNiMo Alloy Steel
Authors: Luo Xiangpeng , Zhao Minghuang , Li Jiayi , Duan Chenghong
Published: December 2019

In this paper, a multi-layer and multi-track finite element model of 24CrNiMo alloy steel by selective laser melting (SLM) is established by using the ABAQUS software. The distribution and evolution of temperature field and stress field and the influence of process parameters on them are systematically studied. The results show that the peak temperature increases from 2153 °C to 3105 °C and the residual stress increases from 335 MPa to 364 MPa with increasing laser power from 200 W to 300 W; the peak temperature decreases from 2905 °C to 2405 °C and the residual stress increases from 327 MPa to 363 MPa with increasing scanning speed from 150 mm/s to 250 mm/s; the peak temperature increases from 2621 °C to 2914 °C and the residual stress decreases from 354 MPa to 300 MPa with increasing preheating temperature from 25 °C to 400 °C. Far away from scanning area, far away from starting point, and the adjacent areas with vertical scanning direction, resulting in a uniform temperature distribution, help to reduce the residual stress. Due to the remelting effect, the interlayer scanning angle changing helps to release the residual stress of the former layer causing a smaller residual stress after redistribution.
High Thermal Conductivity and Anisotropy Values of Aligned Graphite Flakes/Copper Foil Composites
Authors: Zeng Fankun , Xue Chen , Ma Hongbing , Lin Cheng-Te , Yu Jinhong , Jiang Nan
Published: December 2019

Much attention has been paid to graphite flakes/copper (GFs/Cu) composites for thermal management due to their remarkable thermal properties. Most studies focus on the interface interaction between GFs and Cu in composites. However, controlling the orientation of GFs still remains a challenge. Herein, we report a reliable method to ensure consistent orientation of GFs in the composites. Firstly, the disorder GFs were well arranged on the surface of copper foil by tape casting process in the casting machine. Then highly aligned GFs/Cu composites were fabricated by hot pressing process in a vacuum hot-pressing furnace, with the volume fraction of graphite from 30% to 70%. The SEM images show that the obtained GFs/Cu composites presented a layer-by-layer structure or network structure with a different content of GFs. The thermal conductivity of GFs/Cu composites exhibited an extreme anisotropy due to the highly aligned GFs. The ultrahigh thermal conductivity of GFs/Cu composites with 70 vol% GFs reached 741 W/(m·K), while through-plane thermal conductivity was just 42 W/(m·K). The alignment of GFs and interfacial thermal resistance were deeply analyzed and a thermal conductivity model for GFs/Cu composites was established. Our work provides a new idea to significantly enhance the thermal transportation performance of GFs/Cu composites by well controlled alignment of GFs in Cu matrix.
Basalt-Fiber-Reinforced Polyvinyl Acetate Resin: A Coating for Ductile Plywood Panels
Authors: Kramár Samuel , Trcala Miroslav , Chitbanyong Korawit , Král Pavel , Puangsin Buapan
Published: December 2019

The aim of this study was to create a reinforced composite wood-based panel that would be leaned towards the environment Plywood was used as a core material and fiber-reinforced polymer was used as a reinforcement. Conventional resin for the fiber-reinforced polymer was substituted with polyvinyl acetate (PVAC), which has several advantages, such as a lower price, easier handling, and better degradability. The second chosen component, basalt fiber, is cost attractive and environmentally friendly. The combination of one and two layers of fabric with three fiber fractions and 4 mm thick plywood was investigated. The best results were achieved with two layers of fabric and the highest fiber fraction. The improvements of the ultimate bending load and bending stiffness of the plywood in the perpendicular direction were 305% and 325%, respectively. The ultimate load and stiffness of the parallel direction were improved by 31% and 35%, respectively. However, specimens always failed in the compressional zone. The highest reinforcing effect was found with the impact test: The energy required to fracture specimens increased by 4213% and 6150% for one and two layers of fabric, respectively. In conclusion, specimens exhibited high ductility due to the PVAC and basalt fiber. The amount of work and energy required to cause fractures was extensive.
Magnetic, Magnetoelastic and Corrosion Resistant Properties of (Fe–Ni)-Based Metallic Glasses for Structural Health Monitoring Applications
Authors: Sagasti Ariane , Palomares Verónica , Porro Jose María , Orúe Iñaki , Sánchez-Ilárduya M. Belén , Lopes Ana Catarina , Gutiérrez Jon
Published: December 2019

We have performed a study of the magnetic, magnetoelastic, and corrosion resistance properties of seven different composition magnetoelastic-resonant platforms. For some applications, such as structural health monitoring, these materials must have not only good magnetomechanical properties, but also a high corrosion resistance. In the fabricated metallic glasses of composition Fe 73 − x Ni x Cr 5 Si 10 B 12 , the Fe/Ni ratio was varied (Fe + Ni = 73% at.) thus changing the magnetic and magnetoelastic properties. A small amount of chromium ( Cr 5 ) was added in order to achieve the desired good corrosion resistance. As expected, all the studied properties change with the composition of the samples. Alloys containing a higher amount of Ni than Fe do not show magnetic behavior at room temperature, while iron-rich alloys have demonstrated not only good magnetic properties, but also good magnetoelastic ones, with magnetoelastic coupling coefficient as high as 0.41 for x = 0 in the Fe 73 Ni 0 Cr 5 Si 10 B 12 (the sample containing only Fe but not Ni ). Concerning corrosion resistance, we have found a continuous degradation of these properties as the Ni content increases in the composition. Thus, the corrosion potential decreases monotonously from 46.74 mV for the x = 0 , composition Fe 73 Ni 0 Cr 5 Si 10 B 12 to −239.47 mV for the x = 73 , composition Fe 0 Ni 73 Cr 5 Si 10 B 12 .
Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector
Authors: Bilal Muhammad , Iqbal Hafiz M. N.
Published: December 2019

Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.
Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma
Authors: Cigliano Antonio , Pilo Maria Giulia , Mela Marta , Ribback Silvia , Dombrowski Frank , Pes Giovanni Mario , Cossu Antonio , Evert Matthias , Calvisi Diego Francesco , Utpatel Kirsten
Published: December 2019

Background and Objectives: Intrahepatic cholangiocarcinoma (iCCA) is a pernicious tumor characterized by a dismal outcome and scarce therapeutic options. To substantially improve the prognosis of iCCA patients, a better understanding of the molecular mechanisms responsible for development and progression of this disease is imperative. In the present study, we aimed at elucidating the role of the maternal embryonic leucine zipper kinase (MELK) protooncogene in iCCA. Materials and Methods: We analyzed the expression of MELK and two putative targets, Forkhead Box M1 (FOXM1) and Enhancer of Zeste Homolog 2 (EZH2), in a collection of human iCCA by real-time RT-PCR and immunohistochemistry (IHC). The effects on iCCA growth of both the multi-kinase inhibitor OTSSP167 and specific small-interfering RNA (siRNA) against MELK were investigated in iCCA cell lines. Results: Expression of MELK was significantly higher in tumors than in corresponding non-neoplastic liver counterparts, with highest levels of MELK being associated with patients’ shorter survival length. In vitro, OTSSP167 suppressed the growth of iCCA cell lines in a dose-dependent manner by reducing proliferation and inducing apoptosis. These effects were amplified when OTSSP167 administration was coupled to the DNA-damaging agent doxorubicin. Similar results, but less remarkable, were obtained when MELK was silenced by specific siRNA in the same cells. At the molecular level, siRNA against MELK triggered downregulation of MELK and its targets. Finally, we found that MELK is a downstream target of the E2F1 transcription factor. Conclusion: Our results indicate that MELK is ubiquitously overexpressed in iCCA, where it may represent a prognostic indicator and a therapeutic target. In particular, the combination of OTSSP167 (or other, more specific MELK inhibitors) with DNA-damaging agents might be a potentially effective therapy for human iCCA.
Functional Changes in Patients and Morphological Changes in the Lumbar Intervertebral Disc after Applying Lordotic Curve-Controlled Traction: A Double-Blind Randomized Controlled Study
Authors: Lee Chang-Hyung , Heo Sung Jin , Park So Hyun , Jeong Hee Seok , Kim Soo-Yeon
Published: December 2019

Background and Objectives: Lumbar traction is widely used as a non-operative treatment for lumbar intervertebral disc disease. The effect of traditional traction (TT) using linear-type traction devices remains controversial for various reasons, including technical limitations. Thus, the purpose of this study was to compare the effects of the newly developed lumbar lordotic curve-controlled traction (L-LCCT) and TT on functional changes in patients and morphological changes in the vertebral disc. Materials and Methods: A total of 40 patients with lumbar intervertebral disc disease at the L4/5 or L5/S1 level as confirmed by magnetic resonance imaging were recruited and divided into two groups (L-LCCT or TT). The comprehensive health status changes of the patients were recorded using pain and functional scores (the visual analogue scale, the Oswestry Disability Index, and the Roland–Morris Disability Questionnaire) and morphological changes (in the lumbar central canal area) before and after traction treatment. Results: Pain scores were significantly decreased after traction in both groups (p < 0.05). However, functional scores and morphological changes improved significantly after treatment in the L-LCCT group only (p < 0.05). Conclusions: We suggest that L-LCCT is a viable option for resolving the technical limitations of TT by maintaining the lumbar lordotic curve in patients with lumbar intervertebral disc disease.
Research on Operation Efficiency and Membrane Fouling of A2/O-MBR in Reclaimed Water Treatment
Authors: Li Fenfen , An Xinyue , Feng Cuimin , Kang Jianwei , Wang Junling , Yu Hongying
Published: December 2019

Taking the public building domestic wastewater as an example, the combination of the MBR (membrane bioreactor) process and the traditional A2/O (anaerobic-anoxic-oxic) process was established and analyzed in terms of the removal effect of the pollutants, the impact of the microbial community changes on the process, the MBR membrane fouling, the cleaning methods, and the cleaning performance. The results indicated that the effluent water quality of the domestic wastewater treated with the A2/O-MBR process was stable and met the emission requirement to the natural water body. There was good microbial diversity in raw water, the anaerobic tank, the anoxic tank, the aerobic MBR tank and the disinfection tank, and the aerobic MBR tank has a wide variety of aerobic microorganisms, which elevates the removal of organics and the nitrification of ammonia nitrogen and ensures the qualification of nitrogen and phosphorus indexes of the system effluent water. For the fouled membrane, the surface of the contaminated membrane was covered by macromolecular contaminants, causing the membrane flux to drop, and after different cleaning methods to the membrane were compared, it was discovered that the combined use of cleaning agents had better effects than the single ones, and the cleaning method of sodium hydroxide followed by hydrochloric acid showed the best effect, achieving a membrane flux restoration ratio above 80% after cleaning.
Molecular Doping for Hole Transporting Materials in Hybrid Perovskite Solar Cells
Authors: Trifiletti Vanira , Degousée Thibault , Manfredi Norberto , Fenwick Oliver , Colella Silvia , Rizzo Aurora
Published: December 2019

Hybrid lead halide perovskites have been revolutionary in the photovoltaic research field, reaching efficiencies comparable with the most established photovoltaic technologies, although they have not yet reached their competitors’ stability. The search for a stable configuration requires the engineering of the charge extraction layers; in this work, molecular doping is used as an efficient method for small molecules and polymers employed as hole transport materials in a planar heterojunction configuration on compact-TiO2. We proved the viability of this approach, obtaining significantly increased performances and reduced hysteresis on compact titania-based devices. We investigated the photovoltaic performance correlated to the hole transport material structure. We have demonstrated that the molecular doping mechanism is more reliable than oxidative doping and have verified that molecular doping in polymeric hole transport materials leads to highly efficient perovskite solar cells, with long-term stability.
Modelling and Simulation of Sheet Metal Forming Processes
Authors: Oliveira Marta C. , Fernandes José V.
Published: December 2019

Numerical simulation of sheet metal forming processes has become an indispensable tool for the design of components and their forming process, in industries ranging from the automotive, to the aeronautics, packing and household appliances [...]
A Low-Noise-Level Heart Sound System Based on Novel Thorax-Integration Head Design and Wavelet Denoising Algorithm
Authors: Zhang Shuo , Zhang Ruiqing , Chang Shijie , Liu Chengyu , Sha Xianzheng
Published: December 2019

Along with the great performance in diagnosing cardiovascular diseases, current stethoscopes perform unsatisfactorily in controlling undesired noise caused by the surrounding environment and detector operation. In this case, a low-noise-level heart sound system was designed to inhibit noise by a novel thorax-integration head with a flexible electric film. A hardware filter bank and wavelet-based algorithm were employed to enhance the recorded heart sounds from the system. In the experiments, we used the new system and the 3M™ Littmann® Model 3200 Electronic Stethoscope separately to record heart sounds in different noisy environments. The results illustrated that the average estimated noise ratio represented 21.26% and the lowest represented only 12.47% compared to the 3M stethoscope, demonstrating the better performance in denoising ability of this system than state-of-the-art equipment. Furthermore, based on the heart sounds recorded with this system, some diagnosis results were achieved from an expert and compared to echocardiography reports. The diagnoses were correct except for two uncertain items, which greatly confirmed the fact that this system could reserve complete pathological information in the end.
Micromanipulation System for Isolating a Single Cryptosporidium Oocyst
Authors: Penny Hamish , Hayman David T. S. , Avci Ebubekir
Published: December 2019

In this paper, an integrated system for contact micromanipulation of Cryptosporidium oocysts is presented. The system integrates five actuators and a partially automated control system and contacts the oocyst using a drawn glass end effector with tip dimensions of 1 μ m. The system is intended to allow single cell analysis (SCA) of Cryptosporidium—a very harmful parasite found in water supplies—by isolating the parasite oocyst of 5 μ m diameter in a new environment. By allowing this form of analysis, the source of Cryptosporidium can be found and potential harm to humans can be reduced. The system must overcome the challenges of locating the oocysts and end effector in 3D space and contact adhesion forces between them, which are prominent over inertial forces on this scale. An automated alignment method is presented, using the Prewitt operator to give feedback on the level of focus and this system is tested, demonstrating alignment accuracy of <2 μ m. Moreover, to overcome the challenge of adhesion forces, use of dry and liquid environments are investigated and a strategy is developed to capture the oocyst in the dry environment and release in the liquid environment. An experiment is conducted on the reliability of the system for isolating a Cryptosporidium oocyst from its culture, demonstrating a success rate of 98%.
Machinability and Surface Generation of Pd40Ni10Cu30P20 Bulk Metallic Glass in Single-Point Diamond Turning
Authors: Xiong Jie , Wang Hao , Zhang Guoqing , Chen Yanbing , Ma Jiang , Mo Ruodong
Published: December 2019

Pd40Ni10Cu30P20 bulk metallic glass (BMG) is widely used in industrial fields due to its excellent oxidation resistance, corrosion resistance, and thermal stability. However, the lack of research on the machinability and cutting performance of BMG using single-point diamond turning (SPDT) limits its application for engineering manufacturing. In the present research, a series of turning experiments were carried out under different cutting parameters, and the machinability reflected by the quality of machined surface, chip morphology, and tool wear were analyzed. Based on the oxidation phenomenon of the machined surface, a molecular dynamics (MD) simulation was conducted to study the mechanism and suppression of the machined surface oxidation during the cutting. The results show that: (1) The Pd-based BMG had good machinability, where the machined surface roughness could go down to 3 nm; (2) irregular micro/nanostructures were found along the tool path on the outer circular region of the machined surface, which greatly affected the surface roughness; and (3) the cutting heat softened the workpiece material and flattened the tool marks under surface tension, which improved the surface quality. This research provides important theoretical and technical support for the application of BMG in optical mold manufacturing.
Modeling and Analysis of vgs Characteristics for Upper-Side and Lower-Side Switches at Turn-on Transients for a 1200V/200A Full-SiC Power Module
Authors: Zhang Maosheng , Ren Na , Guo Qing , Zhu Xiangwen , Zhang Junming , Sheng Kuang
Published: December 2019

In this work, a 1200V/200A full-SiC half-bridge power module was fabricated for high-power high-frequency application, and the characteristics of gate-source voltage ( v g s ) at turn-on transient under different output power was investigated via experiments, modeling, and simulation. Also, the comparison of the v g s characteristics between the upper-side and lower-side was conducted. From experiments, the v g s characteristics show negative spike issue and it becomes severe under higher output power conditions. On the other hand, the upper-side and lower-side show different characteristics, namely, the v g s spike of upper-side is superimposed by a 83.3 MHz high frequency oscillation during the process of v g s being pulled down, while the v g s spike of lower-side contains no oscillation. The mechanisms behind the influence of output power on the v g s spike characteristics and their difference between the upper-side and lower-side were studied via modeling and simulation. Equivalent RLC (resistance-inductance-capacitance) circuit models were proposed and established for the gate driver loops of the upper-side and lower-side based on the internal structure of the power module. With the help of the proposed models, v g s characteristics of the upper-side and lower-side were simulated and compared with the experimental results. The trend of changes in the v g s pulling-down and oscillation amplitude along with the increasing output power from simulation are consistent with that of the experimental results. In addition, different conditions of gate resistance for the SiC power module are compared. Through the comparison between the experiments and simulations, the validity of the proposed equivalent RLC circuit model and the rationality of the analysis about the mechanisms behind the v g s characteristics at turn-on transient for SiC half-bridge power module are confirmed.
Casting Octahedra for Reproducible Multi-Anvil Experiments by 3D-Printed Molds
Authors: Liu Yingxin , Li Haijian , Lai Xiaojing , Zhu Feng , Rapp Robert P. , Chen Bin
Published: December 2019

Making consistent and precise octahedral pressure media is crucial for reproducible high-pressure experiments in the multi-anvil press. Here we report a new approach of casting octahedra using 3D-printed molds, and pressure calibrations for octahedra both with and without pre-existing gaskets (“fins”). The 3D-printed molds for casting octahedra from either Ceramacast 584-OF or 646 cement improve the reproducibility of the octahedra and allow for a pre-existing central hole (for the high-pressure cell assembly) in the final cast product. Pressure and temperature calibrations of the octahedra have been performed based on phase transitions in bismuth (Bi) and silica (SiO2), respectively, in order to determine the efficiency and reproducibility of pressure generation and thermal insulation for cast octahedra designed for use with 18/12, 14/8, and 10/5 multi-anvil assemblies. The pressure-generating efficiency of the 14/8 and 10/5 octahedra with pre-existing gaskets, cast from the 584-OF cement, is similar to that of the corresponding COMPRES (Consortium for Materials Properties Research in Earth Sciences) octahedra, and more efficient than pre-cast octahedra made from the same material but lacking pre-existing gaskets. The efficiency of pre-gasketed 18/12 octahedra made of the 646 cement is markedly lower than those of the 584 cement. However, the 18/12 large-volume octahedra, cast (with fins) from the ZrO2-based 646 cement, also provides efficient thermal insulation. Casting octahedral solid pressure media for multi-anvil experiments using 3D-printed “injection” molds is a low-cost and low failure-rate alternative for conducting reproducible experiments at high pressure in the multi-anvil apparatus.
Nb and REE Distribution in the Monte Verde Carbonatite–Alkaline–Agpaitic Complex (Angola)
Authors: Amores-Casals Sandra , Gonçalves Antonio Olimpio , Melgarejo Joan-Carles , Martí Molist Joan
Published: December 2019

The Angolan alkaline–carbonatite complex of Monte Verde has a semi-circular shape and is comprised of a central intrusion of foidolite rocks surrounded by concentrically arranged minor bodies of other alkaline rocks and carbonatite magmatic breccias. This rock association is hosted by fenitized Eburnean granites. Concentric swarms of alkaline dykes of late formation, mostly of nepheline trachyte composition, crosscut the previous units. Most high-field strength elements (HFSE) and rare earth elements (REE) are concentrated in pyrochlore crystals in the carbonatite and alkaline breccias. Magmatic fluornatropyrochlore is replaced and overgrown by five secondary generations of pyrochlore formed during subsolidus stages and have higher Th, REE, Si, U, Sr, Ba, Zr, and Ti contents. The second, third, and fourth pyrochlore generations are associated with late fluids also producing quartz and REE rich minerals; whereas fifth and sixth pyrochlore generations are linked to the fenitization process. On the other hand, minerals of the rinkite, rosenbuschite, wöhlerite, eudialyte groups, as well as loparite-(Ce), occur in accessory amounts in nepheline trachyte, recording low to moderate agpaicity. In addition, minor REE-bearing carbonates, silicates, and phosphates crystallize as late minor secondary minerals into carbonatite breccia and alkaline dykes. In conclusion, the scarcity of HFSE and REE minerals at the Monte Verde carbonatite-alkaline-agpaitic complex suggests low metallogenetic interest and economic potential for the outcrops analysed in this study. However, the potential for buried resources should not be neglected.
Lignin-Only Polymeric Materials Based on Unmethylated Unfractionated Kraft and Ball-Milled Lignins Surpass Polyethylene and Polystyrene in Tensile Strength
Authors: Chen Yi-ru , Sarkanen Simo , Wang Yun-Yan
Published: December 2019

Functional polymeric materials composed solely of lignin preparations appeared only very recently. A gradual paradigm shift spanning 56 years has revealed how lignin–lignin blends can upgrade the performance of 100 wt% lignin-based plastics. The view, first espoused in 1960, that lignin macromolecules are crosslinked reduces the plausibility of creating functional polymeric materials that are composed only of lignin preparations. Lignin-based materials would be much weaker mechanically if interstices remain in significant numbers between adjoining macromolecular structures that consist of rigid crosslinked chains. In 1982, random-coil features in the hydrodynamic character of kraft lignin (KL) components were evident from ultracentrifugal sedimentation equilibrium studies of their SEC behavior. In 1997, it was recognized that the macromolecular species in plastics with 85 wt% levels of KL are associated complexes rather than individual components. Finally, in 2016, the first polymeric material composed entirely of ball-milled softwood lignin (BML) was found to support a tensile strength above polyethylene. Except in its molecular weight, the BML was similar in structure to the native biopolymer. It was composed of associated lignin complexes, each with aromatic rings arranged in two domains. The inner domain maintains structural integrity largely through noncovalent interactions between cofacially-offset aromatic rings; the peripheral domain contains a higher proportion of edge-on aromatic-ring arrangements. Interdigitation between peripheral domains in adjoining complexes creates material continuity during casting. By interacting at low concentrations with the peripheral domains, non-lignin blend components can improve the tensile strengths of BML-based plastics to values well beyond those seen in polystyrene. The KL-based plastics are weaker because the peripheral domains of adjoining complexes are less capable of interdigitation than those of BML. Blending with 5 wt% 1,8-dinitroanthraquinone results in a tensile strength above that of polyethylene. Analogous effects can be achieved with 10 wt% maple γ-valerolactone (GVL) lignin which, with a structure close to the native biopolymer, imparts some native character to the peripheral domains of the KL complexes. Comparable enhancements in the behavior of BML complexes upon blending with 10 wt% ball-milled corn-stover lignin (BMCSL) result in lignin-only polymeric materials with tensile strengths well beyond polystyrene.
Synthesis and Structural Determination of New Brassinosteroid 24-Nor-5α-Cholane Type Analogs
Authors: Oyarce Jocelyn , Aitken Vanessa , González César , Ferrer Karoll , Olea Andrés F. , Parella Teodor , Espinoza Catalán Luis
Published: December 2019

Natural brassinosteroids possess a 22R, 23R configuration that appears essential for biological activity. It is, therefore, interesting to elucidate if the activity of brassinosteroids with a short side chain depends on the C22 configuration. Herein, we describe the synthesis of new brassinosteroids analogs with 24-norcholane type of side chain and R configuration at C22. The initial reaction is the dihydroxylation of a terminal olefin that leads to S/R epimers. Three different methods were tested in order to evaluate the obtained S/R ratio and the reaction yields. The results indicate that Upjohn dihydroxylation is the most selective reaction giving a 1.0:0.24 S/R ratio, whereas a Sharpless reaction leads to a mixture of 1.0:0.90 S/R with 95% yield. Using the latter mixture and following a previous reported method, benzoylated derivatives and both S and R brassinosteroids analogs were synthesized. All synthesized compounds were completely characterized by NMR spectroscopy, and HRMS of new compounds are also given. In conclusion, a synthetic route for preparation of new analogs of brassinosteroids of 24-norcholane type and R configuration at C22 were described. It is expected that this will help to elucidate if a configuration at C22 is a structural requirement for hormonal growth activity in plants.
Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells
Authors: Carmona-Hernandez Juan Carlos , Taborda-Ocampo Gonzalo , Valdez Jonathan C. , Bolling Bradley W. , González-Correa Clara Helena
Published: December 2019

Chronic intestinal inflammation is associated with pathophysiology of obesity and inflammatory bowel diseases. Gastrointestinal inflammation increases barrier dysfunction exacerbating the immune response and perpetuating chronic inflammation. Anti-inflammatory flavonoids may prevent this intestinal barrier dysfunction. The purpose of this study was to evaluate the polyphenol composition of Colombian Passiflora edulis var. Flavicarpa (Maracuyá), Passiflora edulis var. Sims (Gulupa), and Passiflora ligularis var. Juss (Granadilla) (passion fruits) and to evaluate their ability to inhibit disruption of intestinal barrier dysfunction of Caco-2 (colorectal adenocarcinoma) cells by an inflammatory cocktail (IC). Polyphenols (flavan-3-ols, phenolic acids, flavonols), xanthenes, and a terpene were identified in passion fruits. Cyanidin 3-rutinoside, (+)-catechin and ferulic acid were the most abundant phenolics in P. edulis var. Flavicarpa, P. edulis var. Sims, and P. ligularis var. Juss, respectively. Fruit extracts prevented loss of transepithelial electrical resistance in Caco-2 cells treated with the IC. Among the extracts, P. ligularis var. Juss was most effective at maintaining Caco-2 transepithelial electrical resistance (TEER) with ~73% relative to the IC-treated cells with about 43% of initial TEER values. This fruit had cyanidin-3-rutinoside, (+)-catechin, (−)-epicatechin, and ferulic acid in its phenolic profile. Results of this work support the hypothesis that consumption of passion fruit extracts could benefit intestinal health.
Vitamin B Complex Treatment Attenuates Local Inflammation after Peripheral Nerve Injury
Authors: Ehmedah Adil , Nedeljkovic Predrag , Dacic Sanja , Repac Jelena , Draskovic Pavlovic Biljana , Vucevic Dragana , Pekovic Sanja , Bozic Nedeljkovic Biljana
Published: December 2019

Peripheral nerve injury (PNI) leads to a series of cellular and molecular events necessary for axon regeneration and reinnervation of target tissues, among which inflammation is crucial for the orchestration of all these processes. Macrophage activation underlies the pathogenesis of PNI and is characterized by morphological/phenotype transformation from proinflammatory (M1) to an anti-inflammatory (M2) type with different functions in the inflammatory and reparative process. The aim of this study was to evaluate influence of the vitamin B (B1, B2, B3, B5, B6, and B12) complex on the process of neuroinflammation that is in part regulated by l-type CaV1.2 calcium channels. A controlled transection of the motor branch of the femoral peripheral nerve was used as an experimental model. Animals were sacrificed after 1, 3, 7, and 14 injections of vitamin B complex. Isolated nerves were used for immunofluorescence analysis. Treatment with vitamin B complex decreased expression of proinflammatory and increased expression of anti-inflammatory cytokines, thus contributing to the resolution of neuroinflammation. In parallel, B vitamins decreased the number of M1 macrophages that expressed the CaV1.2 channel, and increased the number of M2 macrophages that expressed this channel, suggesting their role in M1/M2 transition after PNI. In conclusion, B vitamins had the potential for treatment of neuroinflammation and neuroregeneration and thereby might be an effective therapy for PNI in humans.
Analytical Methodology for Trace Determination of Propoxur and Fenitrothion Pesticide Residues by Decanoic Acid Modified Magnetic Nanoparticles
Authors: Canlı Amine Gizem , Sürücü Bilge , Ulusoy Halil İbrahim , Yılmaz Erkan , Kabir Abuzar , Locatelli Marcello
Published: December 2019

A sensitive, rapid, reliable, and easily applicable method based on magnetic solid phase extraction (MSPE) combined with HPLC-PDA was developed for monitoring propoxur (PRO) and fenitrothion (FEN) pesticides in environmental water samples. The effect of major experimental variables on the extraction efficiency of both the pesticides was investigated and optimized systematically. For this purpose, a new magnetic material containing decanoic acid on the surface of particles was synthesized and characterized by XRD, FT-IR, SEM, EDX, and TGA analysis in detail. The simultaneous determination of pesticide molecules was carried out by using a Luna Omega C18 column, isocratic elution of acetonitrile (ACN): Water (70:30 v/v) with a flow rate of 1.2 mL min−1. After MSPE, the linear range for pesticide molecules (r2 > 0.9982) was obtained in the range of 5–800 and 10–800 ng mL−1, respectively. The limit of detections (LOD) are 1.43 and 4.71 ng mL−1 for PRO and FEN, respectively while RSDs % are below 3.5%. The applicability of the proposed method in four different environmental samples were also investigated using a standard addition-recovery procedure. Average recoveries at two spiking levels were over the range of 91.3–102.5% with RSD < 5.0% (n = 3). The obtained results show that decanoic acid grafted magnetic particles in MSPE combined with HPLC-PDA is a fast and simple method for the determination of PRO and FEN in environmental water samples.
Intramolecular and Metal-to-Molecule Charge Transfer Electronic Resonances in the Surface-Enhanced Raman Scattering of 1,4-Bis((E)-2-(pyridin-4-yl)vinyl)naphthalene
Authors: López-Tocón Isabel , Imbarack Elizabeth , Soto Juan , Sanchez-Cortes Santiago , Leyton Patricio , Otero Juan Carlos
Published: December 2019

Electrochemical surface-enhanced Raman scattering (SERS) of the cruciform system 1,4-bis((E)-2-(pyridin-4-yl)vinyl)naphthalene (bpyvn) was recorded on nanostructured silver surfaces at different electrode potentials by using excitation laser lines of 785 and 514.5 nm. SERS relative intensities were analyzed on the basis of the resonance Raman vibronic theory with the help of DFT calculations. The comparison between the experimental and the computed resonance Raman spectra calculated for the first five electronic states of the Ag2-bpyvn surface complex model points out that the selective enhancement of the SERS band recorded at about 1600 cm−1, under 785 nm excitation, is due to a resonant Raman process involving a photoexcited metal-to-molecule charge transfer state of the complex, while the enhancement of the 1570 cm−1 band using 514.5 nm excitation is due to an intramolecular π→π* electronic transition localized in the naphthalenyl framework, resulting in a case of surface-enhanced resonance Raman spectrum (SERRS). Thus, the enhancement of the SERS bands of bpyvn is controlled by a general chemical enhancement mechanism in which different resonance processes of the overall electronic structure of the metal-molecule system are involved.
Blotting Paper-Derived Activated Porous Carbon/Reduced Graphene Oxide Composite Electrodes for Supercapacitor Applications
Authors: Jiang Qinting , Liu Dandan , Liu Bo , Zhou Tong , Zhou Jin
Published: December 2019

A facile strategy, engineered for low-cost mass production, to synthesize biomass-derived activated carbon/reduced graphene oxide composite electrodes (GBPCs) by one-pot carbonization of blotting papers containing graphene oxide (GO) and zinc chloride (ZnCl2) was proposed. Benefitting from the water absorption characteristic of blotting papers in which the voids between the celluloses can easily absorb the GO/ZnCl2 solution, the chemical activation and reduction of GO can synchronously achieve via one-step carbonization process. As a result, the GBPCs deliver a large specific surface area to accumulate charge. Simultaneously, it provides high conductivity for electron transfer. The symmetric supercapacitor assembled with the optimal GBPCs in 6 M KOH electrolyte exhibits an excellent specific capacitance of 204 F g−1 (0.2 A g−1), outstanding rate capability of 100 F g−1 (20 A g−1). Meanwhile, it still keeps 90% of the initial specific capacitance over 10,000 cycles. The readily available raw material, effective chemical activation, simple rGO additive, and resulting electrochemical properties hold out the promise of hope to achieve low-cost, green, and large-scale production of practical activated carbon composite materials for high-efficiency energy storage applications.
Endocannabinoid System in the Airways
Authors: Bozkurt Turgut Emrah
Published: December 2019

Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of their widespread biological effects. The significant immune-modulatory role of cannabinoids has suggested their therapeutic use in several inflammatory conditions. Airways are prone to environmental irritants and stimulants, and increased inflammation is an important process in most of the respiratory diseases. Therefore, the main strategies for treating airway diseases are suppression of inflammation and producing bronchodilation. The ability of cannabinoids to induce bronchodilation and modify inflammation indicates their importance for airway physiology and pathologies. In this review, the contribution of cannabinoids and the endocannabinoid system in the airways are discussed, and the existing data for their therapeutic use in airway diseases are presented.
Correction: Zhao, L.S., et al. Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia–Reperfusion Injury through Suppression of Oxidative Stress and Inflammation. Molecules 2016, 21, 952.
Authors: Zhao Lisha , Xu Lina , Tao Xufeng , Han Xu , Yin Lianhong , Qi Yan , Peng Jinyong
Published: December 2019

During the course of a review of our publications, an error in the title paper [...]
Investigation on Super-Resolution Focusing Performance of a TE-Polarized Nanoslit-Based Two-Dimensional Lens
Authors: Zhu Yechuan , Zhou Shun , Wang Zhiheng , Yu Yiting , Yuan Weizheng , Liu Weiguo
Published: December 2019

Conventional optics suffer from the diffraction limit. Our recent work has predicted a nanoslit-based two-dimensional (2D) lens with transverse-electric (TE) polarized design that is capable of realizing the super-resolution focusing of light beyond the diffraction limit in the quasi-far field. Furthermore, the super-resolution capability can be kept in a high-refractive-index dielectric over a wide wavelength range from ultraviolet to visible light. Here, we systematically investigate the influence of various factors on the super-resolution focusing performance of the lens. Factors such as lens aperture, focal length and nanoslit length are considered. In particular, the influence of nanoslit length on lens focusing was ignored in the previous reports about nanoslit-based 2D lenses, since nanoslit length was assumed to be infinite. The numerical results using the finite-difference time-domain (FDTD) method demonstrate that the super-resolution focusing capability of a nanoslit-based 2D lens increases with the lens aperture and reduces with the increase of the lens focal length. On the other hand, it is notable that the length of the lens focus is not equal to but smaller than that of the nanoslits. Therefore, in order to achieve a desired focus length, a lens should be designed with longer nanoslits.