bluuebunny/crossref_metadata_2025 huggingface dataset:
The risk of preoperative central nervous system acting medications on delirium following hip or knee surgery: A matched case-control study
Authors: Kassie Gizat Molla , Roughead Elizabeth , Nguyen Tuan , Pratt Nicole , Ellett Lisa Kalisch
Published: January 2024

Aim: To examine the risk of individual central nervous system acting
medicines used preoperatively on delirium after hip or knee surgery.
Methods: A matched case-control study was conducted using data from the
Australian Government Department of Veterans’ Affairs. We included
people 65 years or older who had knee or hip surgery between 2000 and
2019. Cases were people with hip or knee surgery who developed
postoperative delirium and controls were people with hip or knee
surgery, but did not develop postoperative delirium. Use of medicines
including anxiolytics, sedative, and hypnotics, opioid analgesics and
antidepressants prior to surgery was compared between cases and
controls. Results: Cases were more likely to be exposed to nitrazepam
(OR=1.88, 95%CI=1.30-2.73), sertraline (OR=1.53, 95%CI=1.22-1.91),
mirtazapine (OR=1.48, 95%CI=1.18-1.87), venlafaxine (OR=1.56,
95%CI=1.12-2.18), citalopram (OR=1.61, 95%CI=1.24-2.09), escitalopram
(OR=1.39, 95%CI=1.04-1.86) or fluvoxamine (OR=3.57, 95%CI= 1.65-7.75)
prior to surgery than controls. At the class level, exposure to
benzodiazepines (OR=1.20, 95%CI=1.05-1.37) and antidepressants
(OR=1.64, 95%CI=1.47-1.83) prior to surgery was significantly higher in
cases than in controls. The numbers needed to be treated to harm in the
85 years or older age group for one additional delirium case was 20 for
sertraline, 17 for citalopram, 19 for mirtazepine and 10 for nitrazepam.
Conclusion: People who developed delirium following hip or knee surgery
were more likely to be exposed to nitrazepam, sertraline, mirtazapine,
venlafaxine, citalopram, escitalopram or fluvoxamine at the time of
admission for surgery. Planning to reduce use of these medicines well
prior to surgery may decrease the risk of postoperative delirium.
EXPLORING THE ACTIVITY OF SINIGRIN, A GLUCOSINOLATE AS AN ANTIMALARIAL
Authors: Walter Neha , Gorki Varun , Chauhan Monika , Dhingra Neelima , Kaur Sukhbir
Published: January 2024

Background and Purpose: Plant derived antimalarials are indispensable
for malaria treatment and a reliable source of new drugs. The present
study first time explores antimalarial efficacy of sinigrin present in
ethanolic whole plant extract of Thlaspi arvense (EWETA) using in vitro,
in silico and in vivo strategies. Experimental Approach: From EWETA,
sinigrin was revalidated and quantified using HPLC. Schizont maturation
inhibition assay was used to assess its in vitro antiplasmodial activity
followed by the determination of cytotoxicity. Further, docking study
was performed on key metabolic enzymes of P. falciparum using V-Life MDS
tool. Peter’s 4-day test was employed to assess in vivo suppressive
activity. Key Results: Sinigrin exhibited promising activity against
both chloroquine (CQ)-resistant (RKL-9) IC50 5.14 μg/mL and CQ-sensitive
(3D7) IC50 5. 47 μg/mL strains of P. falciparum and was safe in both in
vitro (CC50> 640 μg/mL) and in vivo (LD50 > 2
g/kg) toxicity studies. In addition, virtual screening showed hydrogen
bonding, hydrophobic and van der Waals interactions with amino acid
residues of 3BPM (falcipain-3). Sinigrin illustrated good
(ED50< 50 mg/kg) suppressive activity against P. berghei in
monotherapy and enhanced the activity of artesunate (50 mg/kg) in
combination with 100% survival and no parasite recrudescence. These
observations are further corresponded and supported by Differential
Leucocyte Count (DLC), biochemical and histopathological studies.
Conclusions and implications: The outcomes of in vitro, in silico and in
vivo studies suggest sinigrin as a HIT molecule which may potentially be
used in many ways in drug and vaccine development approaches.
Synthesis and performance of temperature- and acid-resistant ternary-copolymer thickener
Authors: Li Hao , Shi Yongmin , Yang Xiaowu
Published: January 2024

An amphoteric polyacrylamide thickener was synthesized using
2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AM), and
dimethyl diallyl ammonium chloride (DMDAAC). According to the
experimental results, the best polymerization conditions were as
follows: temperature of 45 ℃, AMPS:AM:DMDAAC mass ratio of 1:3:1, and
monomer, initiator, guide agent, crosslinking agent, and urea
concentrations of 27%, 0.6%, 0.15%, 0.3%, and 1%, respectively. The
apparent viscosity, measured at room temperature with a six-speed
rotational viscometer, was 135 and 45 mPa·s in the absence and presence
of 20% HCl, respectively. The temperature resistance of the thickener
solution was evaluated using an AR2000ex rheometer; at 120 °C and a
shear rate of 170 s–1, its apparent viscosity was 99.7 mPa·s. Moreover,
the chemical composition and morphology of the synthesized thickener
were investigated via Fourier-transform infrared spectroscopy and
scanning electron microscopy, respectively.
Chronologic improvement in hair yield with follicular unit extraction with changes in punch devices: A ten-year experience of a single center
Authors: Civas Ekrem , Aksoy Berna , Akpinar Umit
Published: January 2024

Background: Follicular Unit Extraction (FUE) which is a newer hair
transplant procedure was thought to be only usable in limited areas at
the beginning. However, it is the most preferred technique these days.
It is known transection rates have decreased with punch technology (and
experience) over the years. Our clinical experience is that the total
graft numbers and the number of follicular units (FUs) containing 3 or
more hairs gained have increased over the years. Objectives: We analyzed
the data from so-so many male patients who underwent hair
transplantation by FUE method at our clinic retrospectively to elucidate
how the development of punch technology affected the number of total
grafts and FU containing multiple hairs. Methods: Between the years 2011
and 2020, the number of grafts obtained, in male androgenetic alopecia
(AGA) hair transplant patients operated with the FUE method at the
author’s dermatology clinic, was investigated retrospectively. Results:
Overall 1415 cases were retrospectively included in the study. Over the
years, the numbers of total grafts and multi-hair FU gained have
increased in relation to the change in punch devices. Conclusion: Our
study has shown that hair yield has been increased with new punch
technologies.With an increasing hair yield by the aid of evolving punch
technology, hair transplantation with the FUE method has become the
first choice for hair transplantation preferred by both doctors and
patients. Keywords: Hair Follicle / transplantation; Tissue and Organ
Harvesting / instrumentation; Tissue and Organ Harvesting / methods;
Alopecia / surgery; Transplantation, Autologous.
Animal prion diseases: a review of intraspecies transmission
Authors: Gallardo Mauro Julian , Delgado Fernando
Published: January 2024

Animal prion diseases are a group of neurodegenerative, transmissible
and fatal disorders that affect several animal species. The causative
agent called prion, is a misfolded isoform of normal cellular prion
protein, which is found constitutively in cells with higher
concentration in the central nervous system. In this review, we explored
the sources of infection and different natural transmission routes of
animal prion diseases in susceptible populations. Chronic wasting
disease in cervids and scrapie in small ruminants are prion diseases
capable of maintain themselves in susceptible populations through
horizontal and vertical transmission. The other prion animal diseases
can only be transmitted through food contaminated with prions. Bovine
spongiform encephalopathy is the only animal prion disease considered
zoonotic, however, due to its inability to transmit within a population,
it could be controlled. The emergence of atypical cases of scrapie and
bovine spongiform encephalopathy, even the recent report of prion
disease in camels, demonstrates the importance to understand the
transmission routes of prion diseases in order to take measures to
control them and to assess the risks to human and animal health.
Hunting alters viral transmission and evolution
Authors: Fountain-Jones Nicholas , Kraberger Simona , Gagne Roderick , Gilbertson Marie , Trumbo Daryl , Charelston Michael , Salerno Patricia , Funk Chris , Crooks Kevin , Logan Ken , Alldredge Mathew , Dellicour Simon , Baele Guy , Didelot Xavier , VandeWoude Sue , Carver Scott , Craft Meggan
Published: January 2024

Hunting can fundamentally alter wildlife population dynamics, but the
consequences of hunting on pathogen transmission and evolution remain
poorly understood. Here we present a study that leverages a unique
landscape-scale experiment coupled with pathogen transmission tracing,
network simulation and phylodynamics to provide insights into how
hunting shapes viral dynamics in puma (Puma concolor). We show that
removing hunting pressure enhances the role of males in transmission,
increases the viral population growth rate and the role of evolutionary
forces on the pathogen (higher purifying and diversifying selection)
compared with when hunting was reinstated. Changes in transmission could
be linked to short term social changes as male population increases.
These findings are supported through comparison with a region with
stable hunting management over the same time period. This study shows
that routine wildlife management can have profound impacts on pathogen
transmission and evolution not previously considered.
Analysis of the nontrivial zeros for the certain Dirichlet $L$-series
Authors: Yang Xiao-Jun
Published: January 2024

In the present paper we propose a new approach for the generalized
Riemann hypothesis in theoretical framework of the Dirichlet
$L$-series. The Dirichlet’s lambda function is used as the testing
function to prove the generalized Riemann hypothesis. The obtained
results can be also applied to consider the other classes of the
Dirichlet $L$-series.
Inflammatory myofibroblastic tumor of the upper airways harboring a new TRAF3-ALK fusion transcript.
Authors: Ruscio Valentina Di , Mastronuzzi Angela , Russo Ida , Neri Marianna , Stracuzzi Alessandra , Giovannoni Isabella , Tropiano Maria Luisa , Ioris Maria Antonietta De , Milano Giuseppe Maria
Published: January 2024

Inflammatory myofibroblastic tumor (IMT) is a rare disease that mainly
involves the lung and the abdomen with an intermediate clinical course
but a recurrence rate between 15-30%. Radical surgery represents the
golden standard of treatment, while chemotherapy and radiotherapy are
considered for unresectable lesions. The identification of ALK
translocations in IMT opened the option for the use of target
therapies1. Indeed, the ALK inhibitors have changed the treatment
approach for aggressive lesions, improving the prognosis. Intraluminal
upper way IMT is extremely rare and represents a medical challenge. We
reported an endotracheal IMT case presenting a before unknown TRAF3-ALK
fusion transcript.
Network pharmacology and pharmacokinetics strategy decoded the molecular basis of Phyto-neurotherapeutic potential of Zingiber officinale
Authors: Gollapalli Pavan , SJ Aditya Rao , H Manjunatha , Shetty Praveenkumar , N Suchetha kumari , Gnanasekaran Tamizh Selvan
Published: January 2024

Background: The bioactive constituents from Zingiber officinale have
shown a positive effect against neurodegenerative diseases like
alzheimer’s disease (AD) that manifests as progressive memory loss and
cognitive impairment. By coupling enormous available photochemical data
and advanced computational technologies, the possible molecular
mechanism of action of these bioactive compounds was deciphered by
evaluating phytochemicals, target fishing, and network biological
analysis. Experimental Methods: As a result, 175 bioactive compounds and
264 human target proteins were identified. The gene ontology and Kyoto
Encyclopaedia of Genes and Genomes pathway enrichment analysis and
molecular docking were used to predict the basis of vital bioactive
compounds and biomolecular mechanisms involved in the treatment of AD.
Results: The systematic topological analysis of the bioactive
compound-target protein network resulted in identifying nine essential
bioactive compounds (10-Gingerdione, 1-dehydro-[8]-gingerdione,
perillene, farnesol, isovanillin, zingiberone, gingerdione,
gingerenon-B, isoeugenol-methyl-ether), which are found active against
the top 10 target human proteins (APP, AKT1, CHRM1, PRKCD, TTR, SRC,
S1PR3, MAPK3, EP300 and RELA). Amongst selected bioactive compounds,
10-Gingerdione and 1-dehydro-[8]-gingerdione exhibited significant
anti-neurological property against AD targeting amyloid precursor
protein with a binding affinity of -6.0 and -5.6, respectively.
Conclusion: This study suggests that 10-Gingerdione and
1-dehydro-[8]-gingerdione strongly modulates anti-neurological
activity and are associated with pathological features like amyloid-β
plaques and hyperphosphorylated tau protein are found to be critically
regulated by these two target proteins. This comprehensive analysis
provides a clue for further investigation of these natural compound’s
inhibitory activity in drug discovery for AD treatment.
Co-expression of Cocculus hirsutus trypsin inhibitor with Cry1Ab toxin exhibits insect mortality and reduction in development of resistance in insects
Authors: Yadav Reena , Kumar Anil , Bano Nasreen , Singh Priya , Dhar Yogeshwar , Pandey Ankesh , Bag Sumit , Pande Veena , Sanyal Indraneel
Published: January 2024

ChTI (Cocculus hirsutus trypsin inhibitor), a plant serine protease
inhibitor, is a natural plant defense protein effective against
phytophagous insects by inhibiting digestive proteases in guts. We
modified the ChTI gene by codon optimization and expressed it in E.
coli, purified it, and performed insect bioassay, where significant
weight loss with reduced larval growth was observed in both the insect
pests; Helicoverpa armigera and Spodoptera litura. Further, we expressed
the ChTI protein in Arabidopsis thaliana and Solanum lycopersicum,
either individually or pyramided with Bt-Cry1Ab toxin and quantified the
toxicity of the expressed proteins against both insects in the
transgenic plants. We also performed transcriptomic analysis of
transgenic Arabidopsis and tomato plants expressing ChTI protein, where
the enhancement of different pathogenesis-related proteins was observed.
Earlier reports say that insects gradually develop resistance against
toxins, so we developed transgenic plants, co-expressing the two
different toxins from diverse origin, achieving resistance against
insects, and reducing the tendency of insects to develop resistance
against the toxins. Comparative analysis of all the expressed gene
constructs viz. pChTI, pcry1Ab, and pChAb was completed by molecular and
insect biassays. Complete mortality against both insects was observed
without compromising the yield.
Accuracy of Non-Echo Planar Diffusion Weighed Magnetic Resonance Imaging to detect Cholesteatoma in routine clinical healthcare: A Diagnostic Study
Authors: Koro Eleonor , Ögren Emely , Olofsson Katarina , Werner Mimmi
Published: January 2024

Objectives: To determine the accuracy of Non-Echo-Planar Diffusion
Weighed Magnetic Resonance Imaging (non-EPI DW MRI) in diagnosing
cholesteatoma in routine clinical healthcare - a comparison to
otosurgery outcome. Method: A retrospective diagnostic study including
all subjects examined with middle ear non-EPI DW MRI in two regions in
northern Sweden between October 2010, when the use of non-EPI DW MRI
began, and March 2019 when the search was made. Examinations not
performed as non-EPI DW MRI were excluded. Sensitivity, specificity,
positive predictive value, negative predicative value, and likelihood
ratios were calculated using non-EPI DW MRI as the index test and
diagnosis from otosurgery as the reference standard. Results: Fifty-two
subjects with suspicion of cholesteatoma underwent non-EPI DW MRI and
subsequent otosurgery after examination. Non-EPI DW MRI had a
sensitivity of 0.50, specificity of 0.75, positive predictive value of
0.74, negative predictive value of 0.52, positive likelihood ratio of
2.0, and negative likelihood ratio of 0.67. Discussion: The diagnostic
accuracy of non-EPI DW MRI does not reach acceptable levels to be
reliable in the existing everyday clinical setting. The accuracy of the
examination increases when interpreted by an experienced radiologist and
when using the definition of cholesteatoma recommended by The European
Academy of Otology and Neurotology and The Japanese Otological Society.
Assessment of serum prolidase levels in coronary artery stent restenosis
Authors: Memioglu Tolga , Ayhan Selim , Donmez Ibrahim
Published: January 2024

Background: Coronary artery in-stent restenosis is the negative response
caused by the decrease in the artery diameters. Prolidase is an enzyme,
whichplays a role in the formation of new matrix, collagen metabolism
and cell development. There is no study evaluating the serum levels of
prolidase enzyme in patients developing in-stent restenosis. Therefore,
the objective of our study was to reveal the relationship between serum
prolidase levels and in-stent restenosis. Methods: A total of 70
patients who were at medium-to-high risk based on non-invasive tests or
clinical evaluation, and who underwent a coronary angiography in the
cardiology and emergency polyclinics of our hospital from 2013 through
2014 were included in the study. In-stent restenosis was identified in
40 patients. In the other 30 patients, there was no angiographically
determined critical lesion. Serum prolidase levels were measured in all
patients. Results: The mean serum level of prolidase was found to be
statistically significantly higher in the in-stent restenosis group
compared to restenosis free group (p=0.02). The mean serum level of
prolidase level was significantly higher in smokers compared to the
non-smoker patients (p=0.04). It was observed that serum prolidase
levels statistically significantly increased proportionally to the
in-stent restenosis percentage (p=0.04). Conclusions: The results of
this study indicate that, prolidase enzyme levels may enable timely and
and correct assessment of in-stent restenosis, and may contribute to the
decision for changing the treatment or timing to increase intensity of
the treatment in patients undergoing percutaneous coronary intervention
(PCI) with coronary stenting.
Upper and Lower Bounds for Inverse Connective Eccentricity Index of Graphs
Authors: Pattabiraman K , Suganya T
Published: January 2024

A number of topological indices based on vertex eccentricity are already
subject to various studies. In this paper, we obtain several upper and
lower bounds for inverse connective eccentricity index of graphs in
terms of other graph parameters
Electronic and NLO Investigation of Bismuthene Nanosheet as a Promising Photocatalyst
Authors: Kokabi Alireza , Touski Shoeib Babaee , Mardanian Rasul
Published: January 2024

Electronic and photocatalytic properties of single-layer Bismuthene
nanosheets have been investigated as a function of their sizes. It is
shown that Bismuthene nanosheet photocatalytic characteristics are
comparable with the currently available high-ranked photocatalysts. The
mentioned characteristics are enhanced by the extension of nanosheet
along both edges. The nonlinear optics (NLO) analysis for a variety of
nanosheet sizes displays a wide range of absorption on the solar
spectrum. This would be another fascinating characteristic of
water-splitting. The stability of the Bismuthene nanosheet falls by
widening the nanosheet from both sides of Armchair and Zigzag edges. The
variation of the energy gap between HOMO and LUMO levels concerning the
nanosheet width along both Armchair and Zigzag directions has been
explored up to 388 atoms. Regions of chemical activity in Bismuthene are
mainly focused in the middle of nanosheets. This means that either of
Armchair and Zigzag edges in Bismuthene nanosheet demonstrate a
negligible chemically activity.
Mechanistic modeling of a novel oncolytic virus, V937, to describe viral kinetic and dynamic processes following intratumoral and intravenous administration
Authors: Guillen Zinnia P Parra , Freshwater Tomoko , Cao Youfang , Mayawala Kapil , Oteiza Sara Zalba , Garrido Maria , Alwis Dinesh de , Trocóniz Iñaki
Published: January 2024

V937 is an investigational novel oncolytic, non-genetically modified
Kuykendall strain of Coxsackievirus A21 which is in clinical development
for the treatment of advanced solid tumor malignancies. V937 infects and
lyses tumor cells expressing the intercellular adhesion molecule I
(ICAM-I) receptor. We integrated in vitro and in vivo data from six
different preclinical studies to build a mechanistic model that allowed
a quantitative analysis of the biological processes of V937 viral
kinetics and dynamics, viral distribution to tumor, and anti-tumor
response to V937 in human xenograft models in immunodeficient mice
following intratumoral and intravenous administration. Estimates of
viral infection and replication which were calculated from in vitro
experiments were successfully used to describe the tumor response in
vivo under various experimental conditions. Despite the predicted high
clearance rate of V937 in systemic circulation (t1/2=4.3 min), high
viral replication was observed in immunodeficient mice which resulted in
tumor shrinkage with both intratumoral and intravenous administration.
The described framework represents a step towards the quantitative
characterization of viral distribution, replication, and oncolytic
effect of a novel oncolytic virus following intratumoral and intravenous
administrations in the absence of an immune response. This model may
further be expanded to integrate the role of the immune system on viral
and tumor dynamics to support the clinical development of oncolytic
viruses.
Patient’s experience with Arabin cervical pessary during pregnancy: a questionnaire survey
Authors: Seravalli Viola , Strambi Noemi , D’Arienzo Alessandra , Magni Francesco , Bernardi Ludovico , Morucchio Anna , Tommaso Mariarosaria Di
Published: January 2024

Objective To investigate women’s experience with the cervical pessary
for prevention of preterm birth. Design: Retrospecitve questionnaire
study. Setting: Tertiary care hospital in Italy. Population: 166
pregnant women treated with Arabin cervical pessary within one center.
Methods: A questionnaire was administered to all women after delivery.
Main outcome measures: Data about patient’s experience before the
insertion (adequacy of the information received), during treatment
(follow-up, impact on daily life, perceived discomfort, side effects)
and at the time of removal (pain, patient’s expectation met regarding
the treatment) were analysed. Results: Information received before the
insertion of Arabin pessary was considered adequate in 163/166 (98.2%).
An increase of vaginal discharge was experienced by 70/166 (42.2%)
women. Discomfort or other side effects were reported in 13.8% and
16.3% of cases, respectively. Overall, 77% of women reported an
improved quality of life and 94% considered the follow-up during
pregnancy adequate. Removal was moderately painful for 58/166 (35%) of
women. Patient’s expectations regarding the treatment were exceeded in
the majority of cases (75.3%). In a final step, we compared our results
to previous studies suggesting that clinical experience of the health
care specialists in charge may explain why the discrepancy of results.
Conclusion: Although some trials report high rates of non-compliant
patients, this could not be confirmed by our study. In contrast, most
women reported a positive experience and were motivated to continue the
treatment when they were continuously followed by experienced
clinicians.
Remote and rural mothers’ perceptions of risks and safety of intrapartum care: a qualitative study
Authors: Watson Verity , Bryers Helen , Erdem Seda , Krucien Nicolas , Burnside Mary , Woerden Hugo van
Published: January 2024

The views of mothers are important in shaping policy and practice
regarding options for intra-partum care. The aim of this study was to
assess the trade-offs that remote and rural women make regarding
intrapartum care. Methods Qualitative telephone interviews were
undertaken, transcribed and analysed for themes by two researchers. A
diagrammatic analysis was then derived to illustrate the relationship
between the themes. Results 13 interviews were undertaken with women who
had young children and one who was pregnant. All were from the north of
Scotland. Key themes identified related to: risk/safety, distance,
travel, weather, antenatal care, intervention, type and place of care,
the possibility of intra-partum and postnatal transfer, and support by
different professional groups. Discussion and Conclusion This in-depth
study provides insight into the factors that women living in remote and
rural areas consider when making choices regarding intrapartum care.
These views should be incorporated into policy development and inform
antenatal discussion with pregnant women.
THERMOELASTIC ANALYSIS OF FUNCTIONALLY GRADED ANNULAR ROTATING DISC
Authors: Rani Pooja , Singh Kuldip , Muwal Renu
Published: January 2024

This study deals with thermoelastic analysis of annular rotating disc
made of functionally graded materials. Material properties are assumed
to vary along radial direction according to power-law function, and the
Poisson’s ratio is constant. A gradient parameter is chosen between -0.5
to 0.5. When gradient parameter equals to zero, the disc becomes
isotropic disc case. The distributions of radial and tangential stresses
on the disc are obtained for various gradient parameter by means of the
diverse elasticity modulus, thermal conductivity, thermal expansion
coefficient and density.
Surgical repair of a giant unruptured noncoronary sinus of Valsalva aneurysm
Authors: Stiru Ovidiu , geana roxana , Nayyerani Reza , chibulcutean andreea , tulin adrian , Raducu Laura , Bacalbasa Nicolae , Balescu Irina , diaconu camelia , iliescu vlad
Published: January 2024

Abstract: Unruptured aneurysms of Valsalva sinus are most often
asymptomatic conditions discovered accidentally but with fatal potential
whenever complications such as rupture occur. Therefore, whenever
incidentally diagnosed, these pathologic conditions should be repaired
in order to prevent catastrophic complications and even sudden death.
Here we describe a case of an asymptomatic 42 young man with a large
unruptured sinus of Valsalva aneurysm (SVA) originating from a
noncoronary sinus with a competent tricuspid aortic valve. The diagnosis
was made accidentally by transthoracic echocardiography (TTE) and
confirmed by computed tomography angiography (CA) and cardiac
catheterization. The aneurysm was resected on a cardiopulmonary by-pass,
and the sinus was successfully reconstructed with a bovine pericardial
patch preserving the competence of the native aortic valve. In
conclusion, bovine pericardial patch might be successfully used in order
to reconstruct Valsalva sinus in cases presenting aneurysmal dilatation
at this level.
The explicit formula for solution of wave differential equation with fractional derivatives in the multi-dimensional space
Authors: Rahmonov Askar , Durdiev D. K. , Shishkina Elina
Published: January 2024

This paper devoted to the obtaining the explicit solution of
$n$-dimensional wave equation with Gerasimov–Caputo fractional
derivative in the infinite domain with non-zero initial condition and
vanishing condition at infinity. It is shown that this equation can be
derived from the classical homogeneous hyperbolic integro-differential
equation with memory in which the kernel is
$t^{1-\alpha}E_{2-\alpha,
2-\alpha}(-t^{2-\alpha}),
\ \alpha\in(1, 2),$ where
$E_{\alpha, \beta}$ is the
Mittag-Liffler function. Based on Laplace and Fourier transforms the
properties of the Fox H-function and convolution theorem, explicit
solution for the solution of the considered problem is obtained.
Fractional Simpson's type inequalities for twice differentiable convex functions with applications
Authors: Nasir Jamshed , Qaisar Shahid , BUTT SAAD , Ali Muhammad Aamir
Published: January 2024

In this paper, we prove a new identity involving the second derivative
of the function and Riemann-Liouville fractional integrals. The newly
established identity is then used to establish some new Simpson’s type
inequalities for twice differentiable convex functions. Finally, we give
applications of special functions using the newly proved inequalities.
Genetic knockout and general odorant binding/chemosensory proteins interactions: revealed the function and importance of GOBP2 in the yellow peach moth olfactory system
Authors: Jing Dapeng , Prabu Sivaprasath , Zhang Tiantao , Bai Shuxiong , He Kanglai , Wang Zhenying
Published: January 2024

The GOBP2 protein has a unique function in the yellow peach moth,
Conogethes punctiferalis. Several general odorant binding proteins
(GOBPs) have been identified in various lepidopteran species, but the
functional difference between GOBP1 and GOBP2 in recognition of host
plant odorants is still unknown. The functions of GOBP1 and GOBP2 in the
yellow peach moth were evaluated in this study using the CRISPR-Cas9
system. The results revealed the importance of GOBP2 in the olfaction
mechanism in the yellow peach moth. The GOBP1 knocked out larvae’s
perception towards feeding decreased but did not reach a significant
level, while knocking out the GOBP2 and GOBP1/2 genes resulted in huge
differences. On the other hand, electroantennograms (EAG) and wind
tunnel tests showed that the GOBP2 knocked out adult’s sensitivity to
odorants decreased more than GOBP1 knocked out individuals. The STRING
database text mining results grabbed our attention in the
protein-protein interaction studies. In this research, we firstly proved
the existence of physical interactions between GOBPs and chemosensory
proteins (CSP) through the surface plasmon resonance (SPR) and
isothermal titration calorimetry (ITC) methods. Interestingly, the GOBP1
and GOBP2 could not interact with each other, but they can interact with
CSPs. The interaction result indicates that GOBP2 could physically
interact with CSP15, CSP5, and OBP17, whereas GOBP1 could bind only with
CSP5 and CSP10, and the association constant (ka) is also more
substantial than GOBP1. These results strongly suggest the importance of
GOBP2 function in the perception of host plants odorants in the yellow
peach moth.
High-Gravity Technology-Enhanced Activated Sludge Process for Municipal Wastewater Treatment
Authors: Xu Wei , Geng Chun-Xiang , Hou Zheng-Qing , Liu Sheng , Wang Lei , Shao Lei , Xu Yi , Zhao Hua-Zhang
Published: January 2024

Aerobic activated sludge process (AAS) is the most widely used
biological wastewater treatment process, but its treatment efficiency is
limited by low dissolved oxygen (DO) concentration and mass transfer
rate. Herein, high-gravity technology (Higee), an efficient mass
transfer enhancement technique, was used to enhance AAS to improve
municipal wastewater treatment efficiency. Higee-enhanced AAS
(Higee-AAS) rapidly reduced chemical oxygen demand and NH3-N to below
the discharge limits, and it was effective in removing the compounds
(e.g., aliphatic/proteins) that were stubborn in AAS. In Higee-AAS, DO
increased dramatically, and activated sludge became more dispersed with
smaller particle size, which facilitated contact between oxygen and
sludge, improving oxygen utilization rate and microbial activity. The
increases in extracellular polymeric substances and relative abundance
of microorganisms (Bacteroidete, Nitrosomonas, and Nitrospira) in
Higee-AAS were helpful to remove pollutants. Higee-AAS can effectively
improve wastewater treatment efficiency, and it has potential as a new
wastewater treatment technology.
The Impact of Ureterenoscopic Stone Removal Timing on Kidney Functions: A Retrospective Analysis of 137 patients in a Single Center
Authors: Güleser Ahmet , Basaga Yasar , Cengiz Eren , Keske Murat , Gur Ahmet , Karadag Mert Ali
Published: January 2024

Aim: To examine the effect of ureterorenoscopic stone removal timing on
kidney function in unilateral ureteral stones. Methods: The 137 patients
sampled were divided into two groups: 98 patients who underwent surgery
≤ 14 days after the stone diagnosis (Early Surgery Group) and 39
patients who were operated> 14 days after the stone
diagnosis (Late Surgery Group). Preoperative serum creatinine, blood
urea nitrogen (BUN), and GFR were recorded for the patients in both
groups. In the postoperative first mouth, serum creatinine, BUN, and GFR
were again recorded and compared with the preoperative values. Result:
The mean preoperative serum creatinine, GFR, and BUN levels for Early
Surgery Group were 1.25 ± 0.65µmol/L, 80.04 ± 33.6ml/min/1.73m2, 50 ±
16.6mmol/L, respectively. While a decrease was observed in serum
creatinine (0.82 ± 0.22µmol/L, p < 0.001) and BUN (14.08 ±
7.25mmol/L, p < 0.001) levels one month after surgery, the GFR
increased (105.33 ± 21.6ml/min/1.73m2, p < 0.001). In Late
Surgery Group, postoperative serum creatinine levels increased minimally
(0.94 ± 0.33 vs. 0.95 ± 0.30µmol/L, p = 0.102), and GFR decreased (95.15
± 27.3 vs. 93.77 ± 24.3ml/min/1.73m2, p = 0.338). Although there was an
increase in BUN (17.38 ± 9 vs. 17.92 ± 8.8mmol/L, p = 0.283), the
statistical difference was not significant. Conclusion: We believe that
surgical treatment should be planned within two weeks at the latest, as
prolonged obstruction may result in kidney damage
Laboratorio de electromagnetismo
Authors: Dubeibe Fredy L.
Published: January 2024

Laboratorio de Electromagnetismo es una herramienta de apoyo a la docencia y nace con el objetivo de afianzar los conocimientos de electrostática, corrientes eléctricas, circuitos elementales y magnetismo. Su propósito se fundamenta en once prácticas orientadas a la realización de experimentos, a través del adecuado manejo de nstrumentos de precisión y el fortalecimiento de habilidades de análisis. Las prácticas presentadas en Laboratorio de Electromagnetismo son el fruto de la experiencia adquirida en más de diez años de docencia del autor, quien ha escogido las actividades de laboratorio teniendo como referencia las condiciones actuales de los instrumentos, equipos y materiales del laboratorio de Física de la Universidad de los Llanos.
How good are surgeons at disclosing periprosthetic joint infection at the time of revision, based on pre- and intra-operative assessment? A study on 16,922 primary total hip arthroplasties reported to the Norwegian Arthroplasty Register
Authors: Lutro Olav , Mo Synnøve , Tjørhom Marianne Bollestad , Fenstad Anne Marie , Leta Tesfaye Hordofa , Bruun Trond , Hallan Geir , Furnes Ove , Dale Håvard
Published: January 2024

Background and purpose: Revision due to infection, as reported to the Norwegian Arthroplasty Register (NAR), is a surrogate endpoint to periprosthetic joint infection (PJI). We aimed to find the accuracy of the reported causes of revision after primary total hip arthroplasty (THA) compared with PJI to see how good surgeons were at disclosing infection, based on pre- and intraoperative assessment.Patients and methods: We investigated the reasons for revision potentially caused by PJI following primary THA: infection, aseptic loosening, prolonged wound drainage, and pain only, reported to the NAR from surgeons in the region of Western Norway during the period 2010–2020. The electronic patient charts were investigated for information on clinical assessment, treatment, biochemistry, and microbiological findings. PJI was defined in accordance with the Musculoskeletal Infection Society (MSIS) definition. Sensitivity, specificity, and accuracy were calculated.Results: 363 revisions in the NAR were eligible for analyses. Causes of revision were (reported/validated): infection (153/177), aseptic loosening (139/133), prolonged wound drainage (37/13), and pain only (34/40). The sensitivity for reported revision due to infection compared with PJI was 80%, specificity was 94%, and accuracy—the surgeons’ ability to disclose PJI or non-septic revision at time of revision—was 87%. The accuracy for the specific revision causes was highest for revision due to aseptic loosening (95%) and pain only (95%), and lowest for revision due to prolonged wound drainage (86%).Conclusion: The accuracy of surgeon-reported revisions due to infection as representing PJI was 87% in the NAR. Our study shows the importance of systematic correction of the reported cause of revision in arthroplasty registers, after results from adequately taken bacterial samples.
ANALYSIS OF SUPPLY CHAIN MANAGEMENT OF AND PARTNERSHIP PATTERNS IN VEGETABLE ONLINE COMPANY: CASE STUDY AT BEJANA.ID
Authors: Anabel Vania Azalia , Abidin Zainal , Rosanti Novi
Published: January 2024

This study aims to analyze supply chain management of vegetable products, identify supply chain performance based on the estimation of average time and partnership patterns at Bejana.id, Bandar Lampung. The case study method was used to determine the location purposively. Data were collected using questionnaires in December 2022. The sample used purposive sampling, including one person from Bejana.id, six merchant partners, and nine farmer partners. The data analysis method applied for supply chain management and partnership pattern is qualitative, and supply chain management performance is Supply Chain Operation References (SCOR). The results indicated that (1) the Bejana.id supply chain includes farmer and merchant partners, Bejana.id, and B2B (Business to Business) & B2C (Business to Consumers). The flow of products, information, and money are efficient and have not found severe issues, (2) supply chain performance at the supplier partner level is an advantage in standardized products (SP) and parity in perfect order fulfilment (POF), and for the Bejana.id level get the advantage in standardized products (SP), (3) the partnership pattern between Bejana.id and farmer partners is the common trade pattern, and between Bejana.id and merchant partners is the agency pattern. Keywords: e-commerce, partnership, SCOR, supply chain, vegetables
ANALISIS HARGA GABAH KERING PANEN DAN HARGA BERAS PREMIUM TERHADAP NILAI TUKAR PETANI DI JAWA BARAT PERIODE 2019-2021
Authors: Yulianti Nanda Devi , Gunawan Syahrul Ahmad , Hizbandyah Baiturrahmi Nur , Brata Anggita Shakarine , Maesaroh Syti Sarah
Published: January 2024

A measure of farmer welfare knowledge is determined by the farmer exchange rate (NTP). Factors that affect farmers' wealth are the price of harvested grain (GKP) and the price of premium rice. The purpose of this study is to illustrate the analysis of premium rice price at harvest dry grain (GKP) and farmer exchange rate (NTP). The sample used is the monthly time interval from January to December in the 2019-2021 range with 36 data for each variable. Data analysis comes from secondary data taken from the Central Bureau of Statistics (BPS) report using multiple linear regression analysis test method using the SPSS application. The results showed that the price of harvested dry grains (GKP) and the price of premium rice had a positive effect on farmer exchange rates (NTP).  Key words: exchange rates, farmer, rice
The Use of 3D-Based E-Handout on Excretory System Material To Improve Students' Critical Thinking Skills
Authors: Sukroni Nining Widiyanti , Kartimi Kartimi , Mulyani Asep , Marzuki M.
Published: January 2024

Students' critical thinking skills in high school are still lacking. Learning media in textbooks is still less effective and interactive in the learning process. This study aims to analyze the improvement of students' critical thinking skills using 3D-based e-handout. This research is true-experiment research with a pretest-posttest control group design. The population in this study were all eleventh-grade Mathematics and Science major (MIPA) classes at SMAN 1 Ciwaringin, which consisted of 128 students. The samples were classes XI MIPA 1 and XI MIPA 2. This study showed a significant increase in students' critical thinking skills between experimental classes, with an average N-gain value of 0.60 (moderate category), and the control class, with an N-gain value of 0.28 (low category).ABSTRAK: Keterampilan berpikir kritis siswa di sekolah masih kurang. Media pembelajaran yang masih berupa buku paket kurang efektif dan interaktif dalam proses pembelajaran. Penelitian ini bertujuan untuk  menganalisis peningkatan keterampilan berpikir kritis siswa menggunakan e-handout berbasis 3D. Penelitian ini merupakan jenis penelitian true-eksperimen dengan desain penelitian pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh kelas XI MIPA di SMAN A Ciwaringin berjumlah 128 siswa dan sampel yang digunakan adalah kelas XI MIPA 1 dan XI MIPA 2. Terdapat peningkatan keterampilan berpikir kritis siswa yang signifikan antara kelas eksperimen dengan rata-rata nilai N-gain kelas eksperimen 0,60 tergolong kedalam keriteria sedang sedangkan nilai N-gain kelas kontrol 0,28 tergolong kedalam kategori rendah.
Improving Firm Value Through Environmental Performance and Reporting: It’s Effective?
Authors: Lulu Destyn Sofhyana  , Yusvita Nena Arinta
Published: January 2024

This study aims to determine the effect of corporate environmental responsibility on firm value with ICSR as a moderating variable. This type of research is quantitative research using Moderate Regression Analysis (MRA) as data analysis and using secondary data in the form of panel data. The samples used were 19 companies using the purposive sampling method and processed using the Eviews10 application tool. The results showed that partially the environmental accounting reporting and environmental cost variables had no effect on firm value, while environmental performance had a positive and significant effect on firm value. Then ICSR is able to moderate the effect of environmental costs on firm value, but is unable to moderate environmental accounting reporting and environmental costs on firm value.
Islamic Economic Thought of Nyai Hamdanah: Family Economy of a Great Woman with a Dignified Husband
Authors: Siti Musfiqoh
Published: January 2024

Nyai Hamdanah is one of the female figures who has an important role in the history of Islam in the archipelago. Nyai Hamdana’s thoughts related to the economic sector were implemented when accompanying two pious and allamah husbands in service and da’wah. The thought of Nyai Hamdanah that has been tested can be used as a reference to give birth and produce strong and characterful sons and daughters of the nation’s generation in understanding and applying Islamic economics. Muslimah actually do not just demand equal rights, but declare the function of women for one of the economic development of Islam. The potential of women as human resources can be seen in efforts to include women’s roles in the development process starting from upstream to downstream that is sustainable, humane, moderate, tolerant, balanced, straight as well as actions that prioritize efficiency. Excluding the role of women in the development process means a waste of resources and negatively affects the pace of growth and development on all fronts; religious, educational. Social. And also in this study, the field of economics. The role of women in economic matters concenns the role of tradition and transition.
Employee Loyalty Determinants at KSPPS BTM Pekalongan: Job Satisfaction as a Mediating Variable
Authors: Rizky Andrean  , M. Aris Safi’i  , Tamamudin  , AM. Muh. Khafidz Ma’shum  , Shinta Dewi Rismawati
Published: January 2024

Many Sharia Microfinance Institutions in Indonesia have the form of KSPPS. Employee loyalty is very important in financial institutions of any kind. Employee loyalty in financial institutions is not only expected to be able to produce satisfactory performance but also to prevent fraud. This research aims to analyze the effect of HR competency and quality of work life on employee loyalty with job satisfaction as a mediating variable in KSPPS BTM Pekalongan employees. This research is field research with a quantitative approach. The population in this research amounted to 192 employees from the entire office network of KSPPS BTM Pekalongan. The sample in this research amounted to 130 employees determined based on the results of the calculation of the Slovin formula with a margin of error of 5%. Sampling in this research uses a proportional random sampling technique. The data collection technique in this research used a questionnaire with a Likert scale. The data analysis technique used in this research is path analysis. The results showed that HR competency and quality of work life have a significant effect on job satisfaction. HR competency, quality of work life, and job satisfaction have a significant effect on employee loyalty. Job satisfaction mediates the effect of HR competency and quality of work life on employee loyalty.
Palm Payment System: Islamic Finance Perspective
Authors: Muhamad Wildan Fawa’id  , Utama Yopi Yudha , Yuliani  , Nandita Eka Saputri  , Wafi’ Nur Aziza
Published: January 2024

Cashless payments have become an increasingly popular trend in recent years. Cashless payment methods can include the use of credit/debit cards, mobile banking apps, digital wallets, payments via smartphones, or even biometric technologies such as fingerprint scanners or facial recognition. Palm Payment System incorporates fingerprint biometrics in the palm of the hand to facilitate payments, making it safer and more reliable as long as we have a balance, internet network and hands. Descriptive qualitative research methods are research approaches used to describe certain phenomena or events by understanding and describing in depth the characteristics, context, and complexity of the phenomenon. The use of Palm Payment System is in accordance with Islamic finance principles that uphold transparency, honesty, and fairness in business. However, it needs to be improved in supporting infrastructure, the level of community adoption and adaptation. Security and privacy should not be leaked. Accessibility for people with physical disabilities who cannot use palm payment. Minimize technical obstacles due to environmental factors such as extreme temperatures or poor light because it can affect authentication. The latter is affordable in implementation
Development of a Tourism Village Based on Community Based Tourism (CBT) at Situ Tirta Marta Purbalingga from an Islamic Perspective
Authors: Amanah Aida Qur’an  , Rini Meliana  , Azka Nur Diana  , MD. Abu Sayem
Published: January 2024

The Situ Tirta Marta Tourism Village in Karangcegak Village is one of the tourism areas formed from the utilization of local local potential. As for its development, it applies community-based tourism (CBT) to increase tourist attraction. This study discusses how the CBT-based Situ Tirta Marta development strategy has been implemented as well as the economic perspective of Islamic development related to the development of the Situ Tirta Marta Tourism Village in Karangcegak Village, Kutasari District, Purbalingga Regency.

The research method used in this study is descriptive research with a qualitative approach. The subjects in this study were all stakeholders involved, including managers, tourism awareness groups, government, community and visitors to Situ Tirta Marta.

The results of this study concluded that the CBT-based Situ Tirta Marta Tourism Village development strategy that had been implemented was categorized into 3 aspects, namely destinations, marketing as well as institutions and human resources. All of these aspects support the development of Situ Tirta Marta in a better direction. Active support and participation from all stakeholders involved in the stages of tourism development in Karangcegak Village, especially Situ Tirta Marta. The development of tourism sustainability is in accordance with the Islamic development economy which makes humans the center of development and benefit and falah as parts that cannot be ignored. For this reason, the development of Situ Tirta Marta must be directed towards environmentally-friendly development.