bluuebunny/crossref_metadata_2025 huggingface dataset:
LETTER TO WU JIZHONG BY CAO ZHI — A PANEGYRIC OR A PAMPHLET?
Authors:   Moscow State University, Stroganova Nina
Published: March 2022

The focus of the article, Letter to Wu Jizhong (Yu Wu Jizhong shu, 与吴季重书), a sample of Jian’an epistolography, is a message sent by Cao Zhi (曹植, 192–232) to his friend Wu Zhi (吴质). The article contains the translation and analysis of Letter to Wu Jizhong, which has not been studied in Russian sinology yet. Letter to Wu Jizhong is to be considered only in the light of Letter in response to Cao Zhi by Wu Zhi (Da Dong’e wang shu, 答东阿王书). Letter to Wu Jizhong is analyzed as an oratorical speech in writing. The analysis is based on classical rhetorical theories, mainly on Aristotle’s theory of rhetoric. In each of the 3 parts of the Letter… we highlight its subject, theme, problem, thesis, goal (elements of the Inventio). The oratory of the Letter… is epideictic and deliberative. “The topos of Size”, i. e., exaggeration, contributes to the grotesque-satirical effect.
ETHNOGRAPHIC ALBUM OF QING DYNASTY HUANG QING ZHI GONG TU (IMAGES OF TRIBUTARIES OF THE RULING QING DYNASTY) AS A VALUABLE SOURCE OF INFORMATION ON TAIWANESE INDIGENOUS PEOPLES
Authors:   St. Petersburg State University, Cherevko Marina
Published: March 2022

In the third volume (卷, juan) of an 18th-century woodblock publication Images of Tributaries of the Ruling Qing Dynasty (Huang Qing zhi gong tu, 皇清职贡图), among others non-Han ethnic groups, there are thirteen illustrations of Taiwan’s indigenous peoples, including a brief description of their costumes, disposition, and customs. This volume contains illustrations of various types of Taiwanese “barbaric” natives that reveal a great deal about Qing imaginative conception of savagery. They are classified both by administrative divisions and by categories of civilized (熟番) and uncivilized (生番) depending on their adoption of Chinese culture. The entries begin with the civilized savages of Taiwan county, then south to Fengshan county, and then north to Zhuluo county, Zhanghua county, and finally Danshui sub prefecture. The submitted uncivilized savages follow again in sequence from south to north. Last are the uncivilized savages of the inner mountains. The illustrations thus proceed from the most civilized one through increasing degrees of savagery. In each of the thirteen pictures, the differences between the savage figures and civilized figures are emphasized. The depictions of the physical appearances of the civilized and uncivilized savages can demonstrate their relative levels of civilization. The Qing Dynasty’s ethnographical description, which recorded the social culture of the historical tribes, now became particularly valuable because of the lack of a great amount of information on the indigenous tribes of Taiwan. It is quite necessary to study the society, traditions and cultural features of Taiwanese indigenous people in different periods, especially after their integration into the Qing Empire. Huang Qing zhi gong tu is regarded as a very important source for a detailed investigation of different ethnical types of peoples who inhabited the island of Taiwan. We have to analyze the history of aboriginal culture alongside Chinese culture to gain a more rounded insight into the culture and history of Taiwan.
QIU XIAOLONG’S NOVELS: AMERICAN DETECTIVE STORIES WITH CHINESE ROOTS
Authors:   St. Petersburg State University, Mitkina Evgenia
Published: March 2022

Qiu Xiaolong is an American writer born in China, but he has been living in the United States since 1988. He wrote eleven novels about Inspector Chen, who lives in Shanghai and investigates crimes committed in that city. One of the features of Qiu Xiaolong’s work is insertions of poetry. Its main character is an educated person, he writes poetry himself, translates and actively uses the Chinese poetic heritage to express feelings. The author uses the form of a detective novel to show the various problems of modern China (the period covered is from the 1990s to the present day).
“INTRODUCTORY PART” OF KOREAN LITERATURE RELATED COURSES AS A MOTIVATIONAL TOOL
Authors:   St. Petersburg State University, Guryeva Anastasia
Published: March 2022

The issue of teaching Korean literature and motivating students has been important due to the recent changes in Korean studies students’ expectations (interest to Korean popular culture and preference to practically oriented subjects). Literature gradually becomes a discipline demanding new educational approaches and additional efforts as students tend to doubt its relation to the competences necessary for their professional success. The paper presents one of the methods elaborated by the author to make students more motivated and involved in learning Korean literature, i. e., an “introductory course” opening the main course and gives its outline. It aims at giving a clear understanding of what the students will achieve, familiarizing the students with basic specific features of Korean literature relevant for the most of the material to be studied (time saving factor). The introduction provides the “road map” of the course, makes the bridges between literature and the targeted professional level (a motivational tool). This method can be applied to other literatures as well.
Effect of Propeptide Mutations on the Directed Evolution of Rhizomucor
miehei Lipase
Authors: Wang Jue , Bai Rong , Wu Na , Zhang Yumin , Hu Lili
Published: March 2022

Background:

A series of mutants of Rhizomucor miehei lipase (RML) screened through
four rounds of directed evolution were studied. Mutants' triglyceride hydrolysis activity was
assessed, and their genes were sequenced. Results showed that mutations in the propeptide can
improve the activity of RML during evolution. Two parts of propeptide (wild-type and mutant) and
mature region were connected by molecular simulation technology.

Methods:

The spatial structure of the most positive mutants containing the mutations in the
propeptide was mainly characterized by the increase in the opening angle of the lid structure in the
mature region of RML, the enhancement of the hydrophobicity of the active center, and the triad of
the active center shifted outward.

Results:

The three indexes above explain the mechanism of propeptide mutations on the activity
change of the target protein. In addition, statistical analysis of all the mutants screened in directed
evolution showed that: (1) most of the mutants with increased activity contained mutations of the
propeptide, (2) in the later stage of directed evolution, the number of active mutants decreased
gradually, and the mutations of inactivated protein mainly occurred in the mature region, and (3) in
the last round of directed evolution, the mutations distributed in the propeptide improved the mutant
activity further. The results showed that the propeptide reduced RML's evolutionary pressure and
delayed the emergence of the evolutionary platform.

Conclusion:

These findings reveal the role of propeptide in the evolution of RML and provide
strategies for the molecular transformation of other lipases.
Towards Protein Surface Mimetics
Authors: Fairlie David P. , West Michael L. , Wong Allan K.
Published: March 2022

Proteins are generally poor drug candidates due to bioavailability problems that stem from conformational instability, susceptibility to proteolytic degradation, poor membrane penetration, and unfavourable pharmacokinetics. Since many proteins exert their biological activity through relatively small regions of their folded surfaces, their actions could in principle be reproduced by much smaller 'designer' molecules that retain these localised bioactive surfaces but have potentially improved pharmacokinetic/dynamic properties. Unlike proteins, smaller peptides generally lack well defined three dimensional structure in aqueous solution and tend to be conformationally mobile. Considerable progress has been made in recent years towards the use of molecular constraints to stabilise bioactive conformations. By affixing or incorporating templates that fix secondary and tertiary structures of small peptides, synthetic molecules (protein surface mimetics) can be devised to mimic the localised elements of protein structure that constitute bioactive surfaces. This is a promising growth area of medicinal chemistry that could impact significantly on biology and medicine. In this perspective review we summarise and prescribe methods for mimicking individual elements of secondary structure (helices, turns, strands, sheets) and for assembling their combinations into tertiary structures (helix bundles, multiple loops, helix­ loop-helix motifs). A detailed understanding of the features that stabilise secondary and tertiary structures is the key to developing appropriate templates to support and correctly position residues in smaller folded surfaces. The goal is to direct critical amino acids (or surrogates) into the same conformational space and orientation as in bioactive surfaces of a native protein, yet retain sufficient flexibility to bind cooperatively, and with complementarity, to a given receptor. The requirements of size, shape, and directionality for templates to control peptide assembly and folding are discussed in relation to selected mimetics of secondary and tertiary structures. Particularly striking is the general tendency for protease inhibitors and MHC-binding peptides to adopt strand conformations; agonists and antagonists for G protein-coupled receptors to
predominate in turn structures; transcription factors, cytokines and DNA/RNA-binding motifs to be helical; and antigen-recognition segments of antibodies to involve multiple loops.
Combinatorial Chemistry Techniques Applied to Nonpeptide lntegrin Antagonists
Authors: Hoekstra William J. , Poulter Brenda L.
Published: March 2022

The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion recognition sequence RGD (Arg-Giy-Asp) not only have displayed efficacy as antithrombotic agents, but also have promise for the treatment of cancer and osteoporosis. Combinatorial organic syntheses of chemical mini-libraries have facilitated nonpeptide lead optimization of integrin antagonists with marked success. Although these accomplishments have been realized primarily for the discovery of orally active GPIIb/llla antagonist antithrombotics, vitronectin receptor (αvβ3) antagonist research has also benefited from such rapid synthesis. The purpose
of this review is to report progress in combinatorial synthesis lead optimization by highlighting
the drug design strategies and synthetic tactics that have led to improved integrin antagonists.
Amine-Squaramide Catalyzed Asymmetric Michael Addition of Cyclic
Diketones and β,γ-unsaturated α-keto Esters
Authors: Liu Zhi-Jing , Ma Zhi-Wei , Chen Xiao-Pei , Wang Chuan-Chuan , Liu Jun-Tao , Tao Jing-Chao
Published: March 2022

A novel tertiary amine squaramide has been successfully developed and applied to catalyze
the asymmetric Michael addition between cyclic diketones and β,γ-unsaturated α-ketoesters. The catalyst
system performed well with a low catalyst loading of 1 mol% under mild reaction conditions. A
series of synthetically and pharmaceutically useful chiral bicyclic compounds were obtained with both
high yields (up to 97%) and excellent enantioselectivities (up to 97% ee).
Design and Synthesis of Echitamine-inspired Hybrid Analogues Containing
Thiazolidinediones as Potential Pancreatic Lipase Inhibitors
Authors: George Ginson , Auti Prashant S. , Sengupta Pracheta , Paul Atish T.
Published: March 2022

Background:

Obesity is a multifactorial metabolic disease characterised by excessive accumulation
of triglycerides. The prevalence and morbidity rates associated with obesity are increasing tremendously,
posing a significant risk to society. Pancreatic lipase (PL) is a key enzyme responsible for the
digestion of dietary triglycerides; hence its inhibition is considered an attractive target in obesity.

Methods:

In this present work, a new series of echitamine-inspired indole-based thiazolidinedione hybrid
analogues were designed, synthesized, and evaluated for their in vitro PL inhibitory potential. The nature
of inhibition has been identified by enzyme kinetic analysis, whereas in silico molecular modelling tools
(molecular docking and dynamic studies) were used for the identification of the mode of action at the
catalytic site of PL (PDB ID: 1LPB). Fluorescence quenching was used for the identification of the interaction
between the potent analogues with PL.

Results:

The condensation reaction of substituted indole derivatives with TZD in the presence of aqueous
KOH resulted in the formation of the titled analogues. Analogues 7k and 7p displayed a potential PL inhibitory
activity (IC50 = 11.36 and 11.87 μM, respectively). A competitive mode of PL inhibition was
revealed in the enzyme kinetic analysis. A static quenching mechanism was exhibited by the screened
agents on PL. The obtained MolDock scores were aligned with the in vitro PL inhibitory activity (Pearson’s
r - 0.7575, p < 0.05). Moreover, the PL-ligand complexes were stable in the dynamic conditions.

Conclusion:

Analogue 7k exerted the potential activity, and further studies might result in novel lead
molecules.
Progress and Development of Carbazole Scaffold Based as Potential Anti- Alzheimer Agents Using MTDL Approach
Authors: Kumar Nitin , Gupta Pankaj , Bansal Sahil
Published: March 2022

Alzheimer’s is a neurodegenerative disease (NDs) found in old age people with associated most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on a combination of two or more bioactive pharmacophores into a single molecule and this phenomenon has received a great attention in the new era of modern drug discovery and emerging as a choice to treat this complex Alzheimer’s disease (AD). In last fifteen years, many research groups designed, and synthesized new carbazole integrated molecules linked with other bioactive pharmacophores like thiazoles, carvedilol, α- naphthylaminopropan-2-ol, tacrine, ferulic acid, piperazine, coumarin, chalcones, stilbene, benzyl piperidine, adamantane, quinoline, phthalocyanines, α-amino phosphonate, thiosemicarbazones, hydrazones, etc. derivatives using MTDLs approach to confront AD. The present review entails the scientific data on carbazole hybrids as potential Anti-Alzheimer activities from 2007 to 2021 that have shown potential anti-Alzheimer activities through multiple target pathways thereby promising hope for new drug development to confront AD.
Green Synthesis of MnO2 NPs Using Blumea lacera Leaf Extract and its
Antimicrobial Study
Authors: Morbale Smita T. , Patil Satish D.
Published: March 2022

Background:

Green synthesis of nanoparticles has emerged as an interesting and expanding
research area due to environmental friendliness, non-toxicity, cleanliness, and cost-effectiveness. Moreover,
it can be performed at room pressure and temperature. Blumea lacera is described as a valuable medicinal
plant in many vital systems of medicines. The study explored the eco-friendly green synthesis of
MnO2 NPs using Blumea lacera leaf extract.

Methods:

Reduction of potassium permanganate (KMnO4) using Blumea lacera leaf extract was carried
out at room temperature. The crude extract of Blumea lacera was added to metal ion reagents of specific
volume and specific concentration at ambient temperature and stirred continuously using a magnetic stirrer.
The aqueous leaf extract reduced and stabilized the KMnO4 into MnO2 NPs. The MnO2 NPs obtained
from the solution were purified and separated by repeated centrifugation using Remi cooling centrifuge
model C-24.

Results:

The biosynthesized MnO2 NPs characterized by UV–Vis spectroscopy showed an absorption
peak at 400 nm. The XRD studies revealed the spherical shape of MnO2 NPs with an average particle
diameter of 20 nm. FT-IR analysis confirmed the presence of functional groups -OH, C=O, C=C, and CH
triggering the synthesis of MnO2 NPs. Vibrational mode at around 606.62 and 438.81 cm−1 supports the
occurrence of the O–Mn–O bond.

Conclusion:

The synthesized MnO2 NPs were found to be good antibacterial and antifungal agents
against bacterial strains Staphylococcus aureus, B. subtilis, Pseudomonas aeruginosa, E. coli, and fungal
strains C. albicans, Aspergillus niger, and Sclerotium rolfsii.
Physical Activity Mentoring in Schools: An Undergraduate-Mentored Running Intervention for Elementary Students
Authors:   Rice University, 6100 Main Street MS-545, Houston, USA, Kabiri Laura S. , Perkins-Ball Amanda M. ,   Rice University, 6100 Main Street MS-545, Houston, USA, Diep Cassandra S. ,   Rice University, 6100 Main Street MS-545, Houston, USA, Kelavkar Uma ,   Rice University, 6100 Main Street MS-545, Houston, USA, Rodriguez Augusto X. ,   Rice University, 6100 Main Street MS-545, Houston, USA
Published: March 2022

Most children do not meet physical activity guidelines, and school-based programs often fail to increase physical activity levels. However, there has been no intervention pairing college mentors with elementary students to date. The purpose of this paper is to report the feasibility and acceptability, both quantitative and qualitative, of an undergraduate-mentored running program designed to increase physical activity in elementary students. A convergent parallel mixed methods design was used to evaluate the feasibility and acceptability of the physical activity intervention for elementary students. Running W.I.S.E. [with Interscholastic Student Engagement] paired college mentors with individual fifth grade elementary school students for bi-weekly running sessions during the school day in early 2020. Quantitative recruitment and retention data were collected and analysed to determine feasibility and acceptability, respectively. Qualitative data comprising letters written by undergraduate mentors to their mentees after the intervention were analysed. Both feasibility and acceptability were achieved. Recruitment and retention rates [100% each] exceeded the pre-defined feasibility and acceptability criteria. Undergraduate mentors were driven to participate by prosocial, passion-driven, and utility motives. Psychosocial mentor/mentee benefits, as well as observed physiological changes among mentees, were cited as outcomes of participation. Undergraduate-mentored running programs a feasible and acceptable means of increasing physical activity in elementary students. Benefits to both mentors and mentees exist and extend beyond physical health into social and mental health, as well.
Machine-Aided Self-diagnostic Prediction Models for Polycystic Ovary Syndrome: Observational Study
Authors: Zigarelli Angela , Jia Ziyang , Lee Hyunsun
Published: March 2022

Background

Artificial intelligence and digital health care have substantially advanced to improve and enhance medical diagnosis and treatment during the prolonged period of the COVID-19 global pandemic. In this study, we discuss the development of prediction models for the self-diagnosis of polycystic ovary syndrome (PCOS) using machine learning techniques.

Objective

We aim to develop self-diagnostic prediction models for PCOS in potential patients and clinical providers. For potential patients, the prediction is based only on noninvasive measures such as anthropomorphic measures, symptoms, age, and other lifestyle factors so that the proposed prediction tool can be conveniently used without any laboratory or ultrasound test results. For clinical providers who can access patients’ medical test results, prediction models using all predictor variables can be adopted to help health providers diagnose patients with PCOS. We compare both prediction models using various error metrics. We call the former model the patient model and the latter, the provider model throughout this paper.

Methods

In this retrospective study, a publicly available data set of 541 women’s health information collected from 10 different hospitals in Kerala, India, including PCOS status, was acquired and used for analysis. We adopted the CatBoost method for classification, K-fold cross-validation for estimating the performance of models, and SHAP (Shapley Additive Explanations) values to explain the importance of each variable. In our subgroup study, we used k-means clustering and Principal Component Analysis to split the data set into 2 distinct BMI subgroups and compared the prediction results as well as the feature importance between the 2 subgroups.

Results

We achieved 81% to 82.5% prediction accuracy of PCOS status without any invasive measures in the patient models and achieved 87.5% to 90.1% prediction accuracy using both noninvasive and invasive predictor variables in the provider models. Among noninvasive measures, variables including acanthosis nigricans, acne, hirsutism, irregular menstrual cycle, length of menstrual cycle, weight gain, fast food consumption, and age were more important in the models. In medical test results, the numbers of follicles in the right and left ovaries and anti-Müllerian hormone were ranked highly in feature importance. We also reported more detailed results in a subgroup study.

Conclusions

The proposed prediction models are ultimately expected to serve as a convenient digital platform with which users can acquire pre- or self-diagnosis and counsel for the risk of PCOS, with or without obtaining medical test results. It will enable women to conveniently access the platform at home without delay before they seek further medical care. Clinical providers can also use the proposed prediction tool to help diagnose PCOS in women.
Amputation in Kingdom of Saudi Arabia: Etiology, Characteristics and Clinical status from a Large Tertiary Rehabilitation Center (Preprint)
Authors: Shahine Enas M. , Silarbi Mohamed T. , Alzeer Abdullah , Bukhamseen Mostafa Abdul Kareem , Alzaraa Khalid M. , Saba Iram
Published: March 2022

BACKGROUND

Limb amputation significantly impacts the patient's physical, emotional, and social life. Multiple etiological factors may lead to limb amputation. Unfortunately, there is limited data about amputation in Saudi Arabia. Since Sultan Bin Abdulaziz Humanitarian City (SBAHC) is a tertiary center receiving such patients, we collected data from ten years to look at the etiology, characteristics, and clinical impact of amputations in the Kingdom.

OBJECTIVE

Limb amputation has a major impact on the patient’s physical, emotional, and social life. There are multiple etiological factors that may lead to limb amputation. There is limited data about amputation in Saudi Arabia and since Sultan Bin Abdulaziz Humanitarian City is a tertiary center receiving such patients, data from ten years was collected to look at etiology, characteristics, and clinical impact of amputation in the kingdom.

METHODS

A retrospective study of 1409 amputee patients’ data at SBAHC collected over ten years included demographic variables, etiology, site, level, and type of amputation. We also collected Functional independent measurement (FIM) scores for 618 patients.

RESULTS

Males constitute the majority of amputees (75.7%) and the average age in males was higher in males compared to females (45 vs 36 years respectively, p<0.001). Vascular diseases (42.3%) and Trauma (36.8%) were the leading cause of amputation in this cohort. Diabetes mellitus was the most frequent comorbidity (40.5%), followed by hypertension (26.2%). Trans-tibial amputations were the most typical (22.58%), followed by trans-femoral amputation (14.12%). Traumatic trans-femoral amputation was more prevalent among young adults than traumatic trans-tibial amputation. Trauma-related amputation cases were highest in the age group of 21-30 years (69.2%), while vascular related amputations were highest in the age group of 70 and above years (89.5%). FIM scores improved significantly in locomotion (33.6%) followed by transfer (30.6%) and self-care (16.4%) at six-month post discharge compared to admission (all p-values<0.01).

CONCLUSIONS

Vascular pathology arising due to chronic diseases is the primary risk factor that may lead to amputation and warrant primary and secondary prevention programs. Seatbelt enforcement can significantly decrease amputation related to Road Traffic Accidents, which has been the second most familiar cause of amputation.
Circulating illness and changes in thermometer use behavior: a series of cross-sectional analyses, United States, 2019-2021 (Preprint)
Authors: Seifarth Jack , Pinaire Megan , Zicker John , Singh Inder , Bloch Danielle
Published: March 2022

BACKGROUND

Temperature-taking behaviors vary with levels of circulating infectious illness; however, little is known about how these behaviors differ by demographic characteristics.

OBJECTIVE

We investigated differences in temperature-taking frequency and the proportion of readings that were feverish among demographic groups (age, gender, urban/rural status) over influenza offseason, influenza season, and Waves 1, 2, and 3 of the COVID-19 pandemic.

METHODS

Using data from smart thermometers collected from May 1, 2019, to February 28, 2021, across the United States, we calculated the frequency of temperature-taking and the proportion of temperature readings that were feverish. Mixed effects negative binomial and mixed effects logistic regression analyses were performed to identify demographic characteristics associated with temperature-taking frequency and the proportion of feverish readings, respectively. Separate models were fit over five study periods: influenza offseason (n=122,480), influenza season (n=174,191), Wave 1 of COVID-19 (n=350,385), Wave 2 (n=366,489), and Wave 3 (n=391,578).

RESULTS

Both temperature-taking frequency and the proportion of feverish readings differed by study period (ANOVA: P<.001) and were highest during influenza season. During all periods, children aged 2-5 years and 6-11 years had significantly higher frequencies of temperature-taking than users aged 19-30 years, and children had the highest proportion of feverish readings of all age groups, after adjusting for covariates. During Wave 1 of COVID-19, users over age 60 years had 1.79 times (95% CI: 1.76, 1.83) the rate of temperature-taking as users aged 19-30 years, and 74% lower odds (95% CI: 72-75%) of a reading being feverish. Across all periods, males had significantly lower temperature-taking frequency and significantly higher odds of having a feverish reading compared to females. Users living in urban areas had significantly higher frequencies of temperature-taking than rural users during all periods, except Wave 2 of COVID-19, and urban users had higher odds of a reading being feverish in all study periods except Wave 1 of COVID-19.

CONCLUSIONS

Temperature-taking behavior and the proportion of readings that were feverish are associated with both population disease levels and individual demographic characteristics. Differences in the health behavior of temperature-taking may reflect changes in both perceived and actual illness risk. Specifically, older adults may have experienced an increase in perceived risk during the first three waves of COVID-19, leading to increased rates of temperature monitoring, even when their odds of fever were lower than younger adults.
Impact of Clinical-Text-Based Fall Prediction Model on Preventing Extended Hospital Stays for Elderly Inpatients (Preprint)
Authors: Kawazoe Yoshimasa , Shimamoto Kiminori , Shibata Daisaku , Shinohara Emiko , Kawaguchi Hideaki , Yamamoto Tomotaka
Published: March 2022

BACKGROUND

Falls may cause elderly people to be bedridden, requiring professional intervention; thus, prevention is crucial. The use of electronic health records (EHRs) is expected to provide highly accurate risk assessment and length-of-stay data related to falls, which may be used to estimate the costs and benefits of prevention. However, no studies exist that investigate the extent to which hospital stays could be shortened through fall avoidance resulting from the use of prediction tools.

OBJECTIVE

First, the extended length of hospital stays caused by falls among elderly inpatients was estimated. Next, we developed a model that predicts falls by using clinical text as input and evaluated its accuracy. Finally, we estimated the potentially shortened hospital stay that would be made possible by appropriate interventions based on the prediction model.

METHODS

Patients 65 years or older were selected as subjects, and the EHRs of 1,728 falls and 70,586 non-falls were subjected to analysis. The extended stay lengths were estimated using the propensity score-matching of 49 associated variables. Bidirectional encoder representations from transformers and bidirectional Long Short-Term Memory (LSTM) methods were used to predict falls from clinical text. The estimated length of stay and the outputs of the prediction model were used to determine stay reductions.

RESULTS

The extended length of hospital stay due to falls was estimated to be 17.8 days (95% CI: 16.6–19.0), and it fell to 8.6 days when there were unobserved covariants at an odds ratio of 2.0. The accuracy of the prediction model was as follows: area under the receiver operating characteristic curve, 0.851; F-value, 0.165; recall, 0.737; precision, 0.093; and specificity, 0.839. When assuming interventions with 25 or 100% effectiveness against cases where the model predicted a fall, the stay reduction was estimated at 0.038 and 0.154 days/day, respectively.

CONCLUSIONS

The accuracy of the prediction model using clinical text is thought to be higher than the prediction accuracy of conventional assessments. However, our model’s precision remained low at 9.3%. This may be due, in part, to the inclusion of cases in which falls did not occur because of preventative interventions during hospitalization. Nonetheless, it is estimated that interventions for cases when falls were predicted will reduce medical costs by 1,520 yen/day of intervention, even if the preventative effect is 25%. Limitations include the fact that these results cannot be extrapolated to short- or long-term hospitalization cases, and that this was a single-center study.
Comparative Study of Paremiological Units of the Korean and Uzbek Languages
Authors: Furkatovna Bayonkhanova Iroda
Published: March 2022

Annotation: The article gives an idea of the concept of culture of interaction ,self-retention and exchange of views in the process of Appeal. Such concepts as attitude, appeal, communication, discussion, discussion, reasoning are all about ornaments that are suitable for the adornment of a particular nation, that is ,Uzbek and Korean, and have given many definitions to its implementation by ethical and aesthetic norms and rules. In the article, the ilinji was honored in Eastern literature for hunting the human heart, giving him kindness, expressing sincere wishes. The reason is that in the world there is one science, which has become the main subject of literature. This is humanism. And the beginning of this science is the search for a way into the human heart. Both the science and spiritual culture and art of Ilmu have been puzzled about this. Keywords. Proverbs, paremiology, proverbs, phrases and parems, paremiology of the Korean and Uzbek languages, communication, culture of treatment, manners, decency, speech activity, path to the soul, mutual understanding, word vision, the basis of Education Proverbs, expressions, comparisons (antithesis), cognitive terms ... 한국어 속담,관용적 표현, 중의적 표현, 직접접 표현, 동음어, 다의어, 단의어
Using Communicative Competence to Develop Speaking Skills in Higher Education
Authors: Uchkunovich Absalamov Khiloliddin
Published: March 2022

Annotation: In accordance with the concept of modernization of education in Uzbekistan, surveys of communicative teaching of the language acquire special significance, since communicative competence acts as an integrative one, focused on achieving a practical result in mastering the foreign language, as well as on the education, upbringing and development of the student's personality. This constitutes the relevance of this research and this article is devoted to this urgency and its solutions. Keywords: competence, communicative competence, grammatical competence or linguistic competence, higher education system, ability, intrinsic motivation.
Customer mistreatment, employee depression, and organizational citizenship behavior: Emotional intelligence as a moderator
Authors: Jeong Jeeyoon , Lee Ji Hoon
Published: March 2022

Grounded in conservation of resources theory, this study investigated the relationship between customer mistreatment and organizational citizenship behavior by examining the mediating mechanism of depression in the workplace and the moderating role of emotional intelligence. Korean
service employees ( N = 319) completed a survey at two time points spaced 3 weeks apart. We found that customer mistreatment diminished employees' organizational citizenship behavior through their sense of depression in the workplace. The results show that the positive relationship
between customer mistreatment and depression in the workplace was weaker when employees had high emotional intelligence. The negative impact of customer mistreatment on organizational citizenship behavior was less pronounced for participants with high (vs. low) emotional intelligence. Theoretical
and practical implications are discussed.
Impact of Chinese corporate social responsibility on purchase intention: Insights from traditional Chinese culture
Authors: Gong Shijie , Lyu Qinghua , Wang Wei
Published: March 2022

Consumers' perception of corporate social responsibility (CSR) varies in different cultural contexts. We examined whether and to what extent Confucianism, as a Chinese traditional cultural setting, can be applied as a sound foundation of CSR activities. We first constructed the Chinese
CSR model, then explored the impact mechanism of Chinese CSR on consumers' purchase intention. Participants were 415 Chinese consumers who completed the measures. This study yielded the following results: First, consumer–corporate identity partially mediated the relationship between
perceived Chinese CSR and consumers' purchase intention. Cultural identity not only strengthened the relationship between perceived Chinese CSR and purchase intention, but also moderated the mediating effect. We have provided a framework that directs management attention to Chinese CSR elements
and practices in the traditional Confucian culture context, both strategically and operationally.
Coping style mediates the relationship between psychological capital and depression among senior high school students
Authors: Zhu Zhongmin , Sang Biao , Chen Wanfen , Liu Junsheng
Published: March 2022

We explored the mediating effect of coping style in the relationship between psychological capital and depression in a sample of 367 senior high school students from Shanghai, China. We measured their psychological capital, coping style, and depression using the Psychological Capital
Questionnaire for Adolescent Students, the Trait Coping Style Questionnaire, and the Center for Epidemiologic Studies Depression Scale. The results show that psychological capital and positive coping were significantly and positively correlated, psychological capital and positive coping were
significantly and negatively related to negative coping and depression, and negative coping and depression were significantly and positively correlated. After controlling for school type, grade, and gender, both positive and negative coping styles mediated the association between psychological
capital and depression. The results indicate the importance of high levels of psychological capital and positive coping for preventing and alleviating depression in senior high school students.
Rancang Bangun Aplikasi Pemesanan Jasa Perbaikan Komputer, Laptop, dan Smartphone Berbasis Android
Authors: Andramawan Yoko , Ummi Khairul , Saleh Alfa
Published: March 2022

Sesuai dengan perkembangan teknologi yang ada pada saat ini seperti perangkat komputer, laptop dan smartphone tidak selamanya berfungsi dengan baik. Ada kala perangkat tersebut mengalami kerusakan, dan pengguna perangkat itu akan berusaha memperbaikinya dengan cara mendatangi sebuah service centre atau toko perbaikan komputer, laptop dan smartphone. Tentu dalam hal ini, pengguna akan rugi waktu dan tenaga untuk mendatangi toko perbaikan perangkat tersebut. Oleh karena itu, diperlukan adanya sebuah jasa pemesanan online layaknya grab dan gojek. Akan tetapi pemesanan jasa online ini khusus menangani perbaikan komputer, laptop dan smartphone langsung ditempat sehingga para pengguna perangkat tersebut hemat waktu, hemat tenaga, dan tidak susah payah mencari dan mendatangi toko perbaikan komputer, laptop dan smartphone.Dan juga agar dapat mempermudah pengguna perangkat tersebut memesan jasa perbaikan komputer, laptop dan smartphone secara online sesuai dengan kebutuhan kita dan dapat diakses dimana saja tidak ada batasan tempat dan waktu. Dalam hal ini juga sangat bermanfaat untuk sebagian orang dikarenakan untuk teknisi bisa siapa aja mendaftar dan langsung bekerja, layaknya seorang driver ojek online seperti Go-Jek dan Grab.
Knowledge Management System Dalam Pengembangan Kinerja Karyawan Pada Pt. Restu Hajj Haramain Travel Umroh & Haji Plus
Authors: Wahyuni Sri , Ekadiansyah Evri , Setiawan Adil
Published: March 2022

Knowledge dalam suatu perusahaan merupakan asset tak berwujud yang bila dimanfaatkan dengan benar akan memiliki daya saing bagi perusahaan itu sendiri. Knowledge sangat berperan penting dalam kelangsungan operasional perusahaan dimana dengan memanfaatkan lebih banyak pengetahuan, suatu perusahaan dapat menemukan pola, aturan dan konteks sehinga pengetahuan itu akan berguna. PT. Restu Hajj Haramain merupakan perusahaan yang bergerak dalam jasa tour dan travel perjalanan haji dan umroh. Permasalahan yang selama ini ditemukan pada PT. Restu Hajj Haramain adalah pengelolaan pengetahuan yang kurang baik dimana belum ada sistem yang dapat mengelola sumber daya pengetahuan yang tersedia.Selama ini kepada beberapa karyawan perusahaan akan diberikan pelatihan sesuai dengan tugas dan fungsinya, baik pelatihan pada sisi pengoperasian maupun pelatihan untuk pengembangan diri dalam mendukung kegiatan operasional perusahaan.Namun hasil dari pelatihan itu sendiri hanya bermanfaat bagi individu itu sendiri, sehingga apabila dikemudian hari individu itu sudah tidak berkerja lagi atau berhalangan hadir maka perusahaan harus melakukan pelatihan dan pembelajaran kembali kepada individu yang baru.Oleh karena itu, diperlukan suatu bentuk penerapan dari knowledge management system yang dapat digunakan untuk mengelola sumber daya pengetahuan karyawan seputar perusahaan dan operasional perusahaan sehingga tidak terjadi kesenjangan pengetahuan antara setiap karyawan.
Penerapan Metode Certainty Factor dalam Expert Sistem Pendeteksi Dini Lesbian Dan Gay
Authors: Soeheri Soeheri , Sanjaya Andi
Published: March 2022

Lesbian dan Gay di Indonesia sudah semakin pesat berkembang. Lesbian dan Gay sangat berbahaya dilihat dari berbagai pandangan. Dari social, agama dan kesehatan, Lesbian dan Gay sangat banyak dampak negatifnya bagi para pelakunya. Untuk itu peneliti ingin mengurangi tingkat penyebaran Lesbian dan Gay dengan cara mendeteksi Lesbian dan Gay sejak dini, dengan melakuakan penelitian tentang “Expert Sistem Pendeteksi Dini Lesbian dan Gay”. Dengan penelitian ini, diharapkan mampu mendeteksi Lesbian dan Gay sejak dini, sehingga dapat menekan pertumbuhan Lesbian dan Gay. Lesbian dan Gay dapat diobati apabila dapat dideteksi sejak dini, sehingga anak yang diduga Lesbian dan Gay dapat melakukan penanganan secara cepat, agar para pelaku Lesbian dan Gay dapat hidpl normal kembali sesuai dengan norma yang ada. untuk mengidentifikasi kelainan menggunakan metode certainty Factor. Metode Certainty Factor memberikan kepastian terkait berdasarkan fakta peristiwa, yang merupakan sumber dari fakta-fakta yang berasal dari para ahli dan diasumsikan sebagai nilai, yang disebut certainty Factor. Dari hasil tes, akurasi sistem pakar ini sebesar 71.1%.
Aplikasi Pemesanan Tiket Bioskop Berbasis Android Pada Bes Cinema Pangkalpinang
Authors: Putra Rendy Rian Chrisna , Sylfania Dwi Yuny
Published: March 2022

BES Cinema merupakan bioskop pertama di Pangkalpinang, tentu saja kehadiran bioskop ini ditunggu-tunggu masyarakat khususnya bagi pecinta film-film layar lebar. Mereka rela mengantri di loket penjualan tiket dalam antrian yang cukup panjang dan cukup lama hanya untuk mendapatkan tiket film. Tidak jarang sebelum gilirannya membeli tiket, tiket film yang ingin dibeli sudah terisi. Dengan memanfaatkan perkembangan teknologi sekarang khususnya teknologi mobile, masalah tersebut dapat diatasi dengan adanya aplikasi pemesanan tiket bioskop berbasis android. Dengan menggunakan aplikasi ini, pengguna dapat melihat jadwal film yang ditayangkan, jadwal film yang akan ditayangkan, dan dapat memesan tiket. Model pengembangan aplikasi dengan menggunakan waterfall, dan menggunakan metode berorientasi objek untuk pengembangan aplikasinya. Pengujian dilakukan dengan menggunakan teknik Blackbox. Hasil yang diharapkan dengan adanya aplikasi ini dapat mempermudah penonton yang mau membeli tiket bioskop
APLIKASI PENGAMANAN DATA DAN DISISIPKAN PADA GAMBAR DENGAN ALGORITMA RSA DAN MODIFIED LSB BERBASIS ANDROID
Authors: Rambe Muhammad Ridwan , Haryanto Edy Victor , Setiawan Adil
Published: March 2022

Menyimpan username dan password beberapa akun yang kita miliki didalam smartphone tentu bukan pilihan tepat mengingat hal tersebut dapat jatuh ketangan orang lain untuk disalahgunakan. Dibutuhkan sebuah aplikasi yang dapat mengamankan teks dalam perangkat android agar keamanan username dan password yang kita simpan didalam smartphone dapat terjaga. Metode kriptografi dapat digunakan untuk merubah teks menjadi bentuk yang tidak bermakna dengan melakukan perhitungan matematika. Namun perubahan bentuk tersebut menimbulkan kecurigaan oleh pihak lain. Metode steganografi hadir untuk menyembunyikan teks kedalam sebuah media agar teks tersebut tidak diketahui oleh orang lain. Dengan melakukan dua kombinasi antara kriptografi dan steganografi diharapkan dapat menjamin keamanan data username dan password setiap akun yang disimpan didalam smartphone berbasis android.
PERANCANGAN SISTEM PENDETEKSI BANJIR BERBASIS INTERNET OF THINGS
Authors: Fahlevi Muhammad Reza , Gunawan Heri
Published: March 2022

Perkembangan teknologi semakin pesat dari waktu ke waktu. Mulai dari mobil pintar (smart car) yang bisa berjalan sendiri ke berbagai tujuan tanpa pengemudi manusia, hingga perangkat rumah pintar (smart home) semacam Alexa yang bisa otomatis bersuara mengingatkan untuk melakukan aktifitas sesuai jadwal. Seluruh teknologi terbaru ini adalah bagian dari Internet of Things. Internet of Things (IoT) adalah sebuah konsep di mana suatu objek yang memiliki kemampuan untuk mentransfer data melalui jaringan tanpa memerlukan adanya interaksi dari manusia ke manusia atau dari manusia ke komputer. Internet of Things (IoT) adalah struktur di mana objek, orang disediakan dengan identitas eksklusif dan kemampuan untuk pindah data melalui jaringan tanpa memerlukan dua arah antara manusia ke manusia yaitu sumber ke tujuan atau interaksi manusia ke komputer. Dalam penanganan banjir juga diperlukan sebuah sistem berbasis Internet of Things (IoT) yang berfungsi sebagai pendeteksi dini mengenai ketinggian air secara real time sehingga dapat memberikan pemberitahuan kepada masyarakat dan meminimalisir jatuh nya korban jiwa akibat bencana banjir tersebut.
IMPLEMENTASI METODE RSA DAN AES UNTUK MENGAMANKAN FILE WINRAR DAN ZIP
Authors: Nasution Rizki Nanda , Triandi Budi
Published: March 2022

Perkembangan teknologi informasi yang pesat menjadikan informasi menjadi permintaan utama setiap orang atau setiap organisasi, karena informasi sangat penting untuk membantu individu atau organisasi berkembang dalam persaingan global. Demi menjamin keamanan file tersebut, agar tidak jatuh ke tangan orang lain, biasanya seseorang memberikan password kepada Rar dan Zip yang mereka miliki. Rar dan Zip adalah file terkompresi, yang dapat menggabungkan beberapa file menjadi ukuran yang lebih kecil. Agar file lebih aman, telah ditambahkan dua metode enkripsi yaitu metode RSA (Rivest-Shamir-Adleman) dan metode AES (Advanced Encryption Standard). RSA adalah salah satu teknik kriptografi dimana kunci untuk melakukan enkripsi berbeda dengan kunci untuk melakukan dekripsi. sedangkan AES adalah block chiphertext simetrik yang dapat mengenkripsi (encipher) dan dekripsi (decipher) sehingga dapat lebih mudah untuk menentukan pasangan kunci public dan private yang di buat secara random dan tidak bisa di gunakan untuk file yang lain.
PERANCANGAN APLIKASI KAMUS HARDWARE KOMPUTER DENGAN IMPLEMENTASI ALGORITMA LEVENSHTEIN BERBASIS ANDROID
Authors: Fadilla Ayu , Ikorasaki Frans
Published: March 2022

Banyaknya jumlah komponen hardware komputer yang ada saat ini dapat menimbulkan suatu masalah seperti sulitnya untuk mengingatnama, bentuk dan fungsi dari setiap komponen hardware komputer yang ada di pasaran. Berdasarkan masalah tersebut, dibutuhkan sebuah solusi yang dapat membantu pengguna untuk mempermudah dalam mengetahui nama, bentuk beserta fungsi dari sebuah hardware komputer. Dengan memanfaatkan perkembangan teknologi, masalah tersebut dapat diatasi sehingga orang-orang dapat dengan mudah mengetahui nama dari sebuah hardware komputer dan mengetahui bentuk serta fungsinya.Salah satu contoh sederhana aadalah dengan membangun sebuah aplikasi kamus hardware komputer.Dengan kamus ini pengguna dapat mencari informasi suatu hardware komputer dari aplikasi kamus tersebut. Untuk itu penulisakan membuat suatu kamus yang berisikan tentang hardware komputer untuk dapat digunakan.
MONITORING KONDISI UDARA DI KOTA MEDAN DENGAN PENDEKATAN FUZZY LOGIC BERBASIS INTERNET OF THINGS (IoT)
Authors: Sidik Maulana Fajar , Rahmad Iwan Fitrianto
Published: March 2022

Kondisi udara di ruang terbuka khususnya kota Medan cukup memprihatinkan, dilihat dari meningkatnya volume kendaraan bermotor, kurangnya lahan terbuka hijau serta banyak faktor lainya lagi. Kemudian adapun polutan yang dikeluarkan oleh kendaraan bermotor antara lain karbon monoksida (CO), nitrogen oksida (NOx), hidrokarbon (HC), Sulfur dioksida (SO2), timah hitam (Pb) dan karbon dioksida (CO2). Dari beberapa jenis polutan ini, karbon monoksida (CO) merupakan salah satu polutan yang paling banyak yang dihasilkan oleh kendaraan bermotor (Sandri Linna, 2011). Asap kenderaan bermotor, asap sisa hutan yang terbakar Polusi udara yang tak kasat mata memberikan dampak yang buruk bagi manusia, ditambah lagi polusi udara biasanya tidak terlalu terlihat. Lalu Logika fuzzy merupakan salah satu pembentuk soft computing. Logika fuzzy pertama kali diperkenalkan oleh Prof. Lotfi A. Zadeh pada tahun 1965. Dasar logika fuzzy adalah teori himpunan fuzzy. Pada teori himpunan fuzzy, peranan derajat keanggotaan sebagai penentu keberadaan elemen dalam suatu himpunan sangatlah penting. Nilai keanggotaan atau derajat keanggotaan atau membership function menjadi ciri utama dari penalaran dengan logika fuzzy tersebut. (Kusumadewi & Purnomo, 2010) Logika fuzzy digunakan untuk menerjemahkan suatu besaran yang diekspresikan menggunakan bahasa (linguistic), misalkan besaran kecepatan laju kendaraan yang diekspresikan dengan pelan, agak cepat, cepat, dan sangat cepat. Dan logika fuzzy menunjukan sejauh mana suatu nilai itu benar dan sejauh mana suatu nilai itu salah.