bluuebunny/crossref_metadata_2025 huggingface dataset:
Appetite, food intake and gut hormone responses to intense aerobic exercise of different duration
Authors: Holliday Adrian , Blannin Andrew
Published: September 2017

The purpose of the study is to investigate the effect of acute bouts of high-intensity aerobic exercise of differing durations on subjective appetite, food intake and appetite-associated hormones in endurance-trained males. Twelve endurance-trained males (age = 21 ± 2 years; BMI = 21.0 ± 1.6 kg/m2; VO2max = 61.6 ± 6.0 mL/kg/min) completed four trials, within a maximum 28 day period, in a counterbalanced order: resting (REST); 15 min exercise bout (15-min); 30 min exercise bout (30-min) and 45 min exercise bout (45-min). All exercise was completed on a cycle ergometer at an intensity of ~76% VO2max. Sixty minutes post exercise, participants consumed an ad libitum meal. Measures of subjective appetite and blood samples were obtained throughout the morning, with plasma analyzed for acylated ghrelin, total polypeptide tyrosine-tyrosine (PYY) and total glucagon-like peptide 1 (GLP-1) concentrations. The following results were obtained: Neither subjective appetite nor absolute food intake differed between trials. Relative energy intake (intake – expenditure) was significantly greater after REST (2641 ± 1616 kJ) compared with both 30-min (1039 ± 1520 kJ) and 45-min (260 ± 1731 kJ), and significantly greater after 15-min (2699 ± 1239 kJ) compared with 45-min (condition main effect, P < 0.001). GLP-1 concentration increased immediately post exercise in 30-min and 45-min, respectively (condition × time interaction, P < 0.001). Acylated ghrelin was transiently suppressed in all exercise trials (condition × time interaction, P = 0.011); the greatest, most enduring suppression, was observed in 45-min. PYY concentration was unchanged with exercise. In conclusion, high-intensity aerobic cycling lasting up to 45 min did not suppress subjective appetite or affect absolute food intake, but did reduce relative energy intake, in well-trained endurance athletes. Findings question the role of appetite hormones in regulating subjective appetite in the acute post-exercise period.
KH-type splicing regulatory protein is a new component of chromatoid body
Authors: Zhang Huijuan , Wang Guishuan , Liu Lin , Liang Xiaolin , Lin Yu , Lin Yi-Yu , Chou Chu-Fang , Liu Mo-Fang , Huang Hefeng , Sun Fei
Published: September 2017

The chromatoid body (CB) is a specific cloud-like structure in the cytoplasm of haploid spermatids. Recent findings indicate that CB is identified as a male germ cell-specific RNA storage and processing center, but its function has remained elusive for decades. In somatic cells, KH-type splicing regulatory protein (KSRP) is involved in regulating gene expression and maturation of select microRNAs (miRNAs). However, the function of KSRP in spermatogenesis remains unclear. In this study, we showed that KSRP partly localizes in CB, as a component of CB. KSRP interacts with proteins (mouse VASA homolog (MVH), polyadenylate-binding protein 1 (PABP1) and polyadenylate-binding protein 2 (PABP2)), mRNAs (Tnp2 and Odf1) and microRNAs (microRNA-182) in mouse CB. Moreover, KSRP may regulate the integrity of CB via DDX5-miRNA-182 pathway. In addition, we found abnormal expressions of CB component in testes of Ksrp-knockout mice and of patients with hypospermatogenesis. Thus, our results provide mechanistic insight into the role of KSRP in spermatogenesis.
Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research
Authors: Wangler Michael F , Yamamoto Shinya , Chao Hsiao-Tuan , Posey Jennifer E , Westerfield Monte , Postlethwait John ,   Members of the Undiagnosed Diseases Network (UDN), Hieter Philip , Boycott Kym M , Campeau Philippe M , Bellen Hugo J
Published: September 2017

Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly involve the use of next-generation sequencing and comparative genomic hybridization methods. These efforts are limited by a lack of knowledge regarding gene function, and an inability to predict the impact of genetic variation on the encoded protein function. Diagnostic challenges posed by undiagnosed diseases have solutions in model organism research, which provides a wealth of detailed biological information. Model organism geneticists are by necessity experts in particular genes, gene families, specific organs, and biological functions. Here, we review the current state of research into undiagnosed diseases, highlighting large efforts in North America and internationally, including the Undiagnosed Diseases Network (UDN) (Supplemental Material, File S1) and UDN International (UDNI), the Centers for Mendelian Genomics (CMG), and the Canadian Rare Diseases Models and Mechanisms Network (RDMM). We discuss how merging human genetics with model organism research guides experimental studies to solve these medical mysteries, gain new insights into disease pathogenesis, and uncover new therapeutic strategies.
Plasma protein absolute quantification by nano-LC Q-TOF UDMSE for clinical biomarker verification
Authors: Ilies Maria , Iuga Cristina Adela , Loghin Felicia , Dhople Vishnu Mukund , Hammer Elke
Published: September 2017

Background and aims. Proteome-based biomarker studies are targeting proteins that could serve as diagnostic, prognosis, and prediction molecules. In the clinical routine, immunoassays are currently used for the absolute quantification of such biomarkers, with the major limitation that only one molecule can be targeted per assay. The aim of our study was to test a mass spectrometry based absolute quantification method for the verification of plasma protein sets which might serve as reliable biomarker panels for the clinical practice.Methods. Six EDTA plasma samples were analyzed after tryptic digestion using a high throughput data independent acquisition nano-LC Q-TOF UDMSE proteomics approach. Synthetic Escherichia coli standard peptides were spiked in each sample for the absolute quantification. Data analysis was performed using ProgenesisQI v2.0 software (Waters Corporation).Results. Our method ensured absolute quantification of 242 non redundant plasma proteins in a single run analysis. The dynamic range covered was 105.86% were represented by classical plasma proteins. The overall median coefficient of variation was 0.36, while a set of 63 proteins was found to be highly stable. Absolute protein concentrations strongly correlated with values reviewed in the literature.Conclusions. Nano-LC Q-TOF UDMSE proteomic analysis can be used for a simple and rapid determination of absolute amounts of plasma proteins. A large number of plasma proteins could be analyzed, while a wide dynamic range was covered with low coefficient of variation at protein level. The method proved to be a reliable tool for the quantification of protein panel for biomarker verification in the clinical practice.
Giardia duodenalis Associated with Intestinal Metaplasia of the Stomach
Authors: Gheorghe Cristian , Cotruta Bogdan , Becheanu Gabriel , Dumbrava Mona , Verban Stefania
Published: September 2017

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Heller myotomy and endoscopic balloon dilation may be equally effective in the shortand long-term
Authors: Bancila Ion , Gheorghe Cristian
Published: September 2017

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Effectiveness and Safety of Golimumab in Treating Outpatient Ulcerative Colitis: A Real-Life Prospective, Multicentre, Observational Study in Primary Inflammatory Bowel Diseases Centers
Authors: Tursi Antonio , Allegretta Leonardo , Buccianti Nello , Della Valle Nicola , Elisei Walter , Forti Giacomo , Faggiani Roberto , Gallina Sara , Hadad Yusef , Larussa Tiziana , Lauria Angelo , Luzza Francesco , Lorenzetti Roberto , Mocci Giammarco , Penna Antonio , Polimeni Natale , Pranzo Giuseppe , Ricciardelli Cristina , Zampaletta Costantino , Picchio Marcello
Published: September 2017

Background & Aims: Golimumab (GOL) has been recently approved in Italy for the treatment of ulcerative colitis (UC) unresponsive to standard treatments. Our aims were to assess the real-life efficacy and safety of GOL in managing UC outpatients in Italian primary Inflammatory Bowel Diseases (IBD) centres.Methods: Consecutive UC outpatients with at least 3-months follow-up were enrolled. Primary end-point was the induction and maintenance of remission in UC, defined as Mayo score ≤2, at 6-month follow-up.Results: Ninety-three patients were enrolled. At 6-month follow-up, remission was obtained in 34 (36.5%) patients. Shorter duration of disease was the only significant predictive factor of remission. Clinical response was achieved in 60 (64.5%) patients, while mucosal healing (MH) was obtained in 18 (19.3%) patients. Sixteen (47.0%) patients under remission were still under therapy with steroids. C-reactive protein and fecal calprotectin significantly dropped during the follow-up (p<0.001 for both proteins). Adverse events occurred in 4 (4.3%) patients and 3 of them stopped treatment. Colectomy was performed in only one patient (1.1%).Conclusions: Golimumab seems to be safe and effective in inducing and maintaining remission in real life UC outpatients.Abbreviations: ADA: Adalimumab; CRP: C-reactive Protein; GOL: Golimumab; FC: Fecal calprotectin; IBD: Inflammatory Bowel Diseases; IFX: Infliximab; IQR: Interquartile range; MH: Mucosal Healing; SC: Subcutaneously; TBC: Tuberculosis; TNFα: Tumor necrosis factor α; UC: Ulcerative Colitis.
Bismuth-based Quadruple Therapy Following H. pylori Eradication Failures: a Multicenter Study in Clinical Practice
Authors: Zullo Angelo , De Francesco Vincenzo , Bellesia Annamaria , Vassallo Roberto , D’Angelo Audenzio , Scaccianoce Giuseppe , Sacco Rodolfo , Bresci Giampaolo , Eramo Annarita , Tanzilli Anna , Ridola Lorenzo , Alvaro Domenico , Londoni Claudio , Brambilla Gianfranco , Manta Raffaele , Di Ciaula Agostino , Portincasa Piero
Published: September 2017

Background & Aims: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice.

Methods: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy. All patients received a rescue quadruple therapy with Pylera (3 capsules four times daily) and esomeprazole 20 mg (1 tablet twice daily) for 10 days. H. pylori eradication was assessed by using Urea Breath Test 4-6 weeks following therapy ending. H. pylori eradication rates, compliance, and side-effects were calculated.

Results: A total of 208 patients in the 9 participating centres were enrolled. Overall, 180 patients were successfully cured from the infection, accounting for 86.5% (95% CI 81.9-91.2) and 92.3% (95% CI 88.6-96.1) eradication rates at intention-to-treat analysis and at per protocol analysis, respectively. Cure rates were similar across patients who failed one to three previous therapy attempts, but the success rate fell to 67% after 4 or more therapy failures. Compliance to therapy was good in 198 (95.2%) patients, whilst in 7 (5.3%) cases the therapy was interrupted within 5 days due to side effects. A total of 97 (46.6%) patients complained of at least one side effect; nausea, diarrhea and vomiting were the most frequently reported.

Conclusions: Our study found that this bismuth-based quadruple therapy is highly effective as second-line and rescue therapy for H. pylori eradication in clinical practice.

Abbreviations: CI: confidence intervals; ITT: intention-to-treat; PP: per protocol; UBT: urea breath test.
Value of Telemonitoring and Telemedicine in Heart Failure Management
Authors: Gensini Gian Franco ,   Digital SIT (Italian Telemedicine Society), Alderighi Camilla ,   Fiorentino Institute of Care and Assistance (IFCA), Florence, Italy, Rasoini Raffaele ,   Fiorentino Institute of Care and Assistance (IFCA), Florence, Italy, Mazzanti Marco ,   International Research Framework on Artificial Intelligence in Cardiology, Royal Brompton Hospital and Harefield NHS Foundation Trust, London, UK, Casolo Giancarlo ,   Cardiology Unit, New Versilia Hospital, Lido di Camaiore (LU), Italy
Published: September 2017

The use of telemonitoring and telemedicine is a relatively new but quickly developing area in medicine. As new digital tools and applications are being created and used to manage medical conditions such as heart failure, many implications require close consideration and further study, including the effectiveness and safety of these telemonitoring tools in diagnosing, treating and managing heart failure compared to traditional face-to-face doctor–patient interaction. When compared to multidisciplinary intervention programs which are frequently hindered by economic, geographic and bureaucratic barriers, non-invasive remote monitoring could be a solution to support and promote the care of patients over time. Therefore it is crucial to identify the most relevant biological parameters to monitor, which heart failure sub-populations may gain real benefits from telehealth interventions and in which specific healthcare subsets these interventions should be implemented in order to maximise value.
Chapeuzinho Vermelho: caminhos percorridos
Authors: Sousa Denise Dias de Carvalho
Published: September 2017

Este ensaio tem o objetivo de analisar a estrutura do conto de fadas com base no caminho percorrido por Chapeuzinho Vermelho em três versões: a de Perrault, a dos irmãos Grimm e a de Chico Buarque, tendo como focos principais as ações de Chapeuzinho e a presença do lobo. As versões serão retomadas numa perspectiva intertextual, levando em consideração a “ordem” e a “partida” associada a uma “busca”, elementos dos contos maravilhosos, classificados por Propp (2006) como invariantes. Além disso, servirão como ponto de partida para a discussão o contexto histórico-social no qual os autores estavam inseridos quando publicaram sua versão e possíveis motivos que os levaram a decidir por inclusão ou exclusão de personagens, elementos, ações e desfechos.********************************************************************Little Red Riding Hood: paths takenAbstract: This paper aims to analyze the structure of the fairy tale based on the path taken by Little Red Riding Hood in three versions: the Perrault, the Grimm brothers and Chico Buarque, the main focus of the actions and Hood the presence of the wolf. The versions will be taken over in a intertextual perspective, taking into account the “order” and “start” associated with “search”, elements of the wonderful tales, ranked by Propp (2006) as invariant. In addition, they serve as a starting point for discussion the historical and social context in which the authors were entered when published its version and possible reasons that led them to decide for inclusion or exclusion of characters, elements, actions and outcomes.Keywords: Fairy Tale; Little Red Riding Hood; Perrault; Brothers Grimm; Chico Buarque
A travessia do tempo: a encenação da ambiguidade e a (im)possibilidade da ancestralidade em O outro pé da sereia, de Mia Couto
Authors: Alavarce Camila Silva , Martins Gisele Pimentel
Published: September 2017

O presente estudo tem como foco analisar como, no projeto literário de Mia Couto, em O outro pé da sereia, há a problematização do tempo e da ancestralidade a partir da construção estética do espaço. Há, no romance, especificamente no capítulo “A travessia do tempo”, metáforas capazes de sugerir a encenação dos embates, e das rasuras deles decorrentes, provocados pela reencenação de rituais antigos no seio da família Rodrigues. Tais rasuras são explicitadas a partir de situações bastante ambíguas experimentadas pelas personagens centrais do romance, Constança e Mwadia, mãe e filha, no interior da casa materna, espaço privilegiado para servir de palco aos mais ambíguos embates. Situação esta que metaforiza a condição atual de Moçambique. Para sustentar este estudo, foram utilizados os estudiosos Assman, Halbwachs,Gama-Khalil, Bhabha, Braúna e Bachelard.********************************************************************The crossing time: the staging of ambiguity and the (im)possibility of ancestry in O outro pé da sereia, by Mia CoutoAbstract: This study focuses on the analysis of how, the literary project of Mia Couto, in O Outro Pé da Sereia, there is a questioning of time and ancestry from the aesthetic construction of space. There are, in the novel, specifically in Chapter “A travessia do tempo”, metaphors able to suggest the scenario of conflicts, and their erasures arising, caused by the restaging of ancient rituals in the family Rodrigues. Such erasures are made explicit from quite ambiguous situations experienced by the main characters of the novel, Constance and Mwadia, mother and daughter, inside the mother’s house, privileged space to serve as a stage to the more ambiguous conflicts. Situation that metaphorizes the current condition of Mozambique. To support this study, the works of Assman, Gamma-Khalil, Bhabha, Braunstone and Bachelard were used.Keyword: Ancestry; Ambiguity; Space; Time; Mia Couto
WEINHARDT, Marilene (Org.). Ficções contemporâneas: histórias e memórias. Ponta Grossa: Editora UEPG, 2015. 261 p.
Authors: Hülsendeger Margarete
Published: September 2017

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TAVARES, Gonçalo M. Os velhos também querem viver. Alfragide: Editorial Caminho, 2014. 91 p.
Authors: Vieira Susana
Published: September 2017

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Efficiency of temporary storage of geothermal waters in a lake system: Monitoring the changes of water quality and bacterial community structures
Authors: Szirányi Barbara , Krett Gergely , Kosáros Tünde , Janurik Endre , Pekár Ferenc , Márialigeti Károly , Borsodi Andrea K.
Published: September 2017

Disposal of used geothermal waters in Hungary often means temporary storage in reservoir lakes to reduce temperature and improve water quality. In this study, the physical and chemical properties and changes in the bacterial community structure of a reservoir lake system in southeast region of Hungary were monitored and compared through 2 years, respectively. The values of biological oxygen demand, concentrations of ammonium ion, total inorganic nitrogen, total phosphorous, and total phenol decreased, whereas oxygen saturation, total organic nitrogen, pH, and conductivity increased during the storage period. Bacterial community structure of water and sediment samples was compared by denaturing gradient gel electrophoresis (DGGE) following the amplification of the 16S rRNA gene. According to the DGGE patterns, greater seasonal than spatial differences of bacterial communities were revealed in both water and sediment of the lakes. Representatives of the genera Arthrospira and Anabaenopsis (cyanobacteria) were identified as permanent and dominant members of the bacterial communities.
MHC-II MARKER POTENTIAL LINKED TO MOTILE AEROMONAD SEPTICAEMIA DISEASE RESISTANCE IN AFRICAN CATFISH (Clarias gariepinus)
Authors: Suprapto Rommy , Alimudddin Alimuddin , Nuryati Sri , Imron Imron , Marnis Huria , Iswanto Bambang
Published: September 2017

One of the important issues in catfish farming is motile aeromonad septicaemia (MAS) disease caused by the bacterium Aeromonas hydrophila. This study aimed to find the MHC-II marker potential for marker-based selection to generate MAS disease resistance of African catfish. PCR method was applied to identify catfish (body length: 7-8 cm) population that have MHC-II marker. Fish with and without the marker were then challenged by intraperitonially injecting of 0.1 mL/fish with A. hydrophila (105 cfu/mL). The results showed that the survival of fish having MHC-II marker (77.50 ± 4.00%) was higher than that of fish without the marker (53.33 ± 4.77%). Fish carrying MHC-II marker fish has also higher total erythrocytes, total leukocytes, phagocytic activity, and hematocrit levels than that of fish without the marker. The PCR results using specific primer for MHC-II showed a specific DNA band of 426 bp in fish having the marker, while there were no DNA bands in fish without the marker. Results of the PCR analyses showed that the percentage of progenies carrying MHC-II marker was 80%, while progenies from broodstock without the marker was 0%; this indicated that MHC-II marker could be inherited to the offsprings. Thus, the MHC-II marker could be used as a molecular marker of MAS disease resistance catfish.
Einflussfaktoren auf die Kalziumkonzentration im Erstkolostrum bei Holstein-Friesian-Kühen und deren Beziehung zur postpartalen Kalziumkonzentration im Blut
Authors: Staufenbiel Rudolf , Karl Maria
Published: September 2017

Ziel: Untersuchung von Einflussfaktoren auf die Kalziumkonzentration im Erstkolostrum mit Prüfung folgender Hypothesen: Die Laktationszahl ist der entscheidende Einflussfaktor auf die Kalziumkonzentration und es besteht ein Zusammenhang zur postpartalen Blutkalziumkonzentra -tion. Material und Methoden: Von April 2012 bis März 2013 erfolgte eine Beobachtungsstudie auf einem kommerziellen Milchviehbetrieb (2278 Holstein-Friesian-Kühe) mit Analyse folgender Variablen: Menge und Kalziumkonzentration des Kolostrums; Blutserumkonzentrationen von Kalzium, Phosphor, freien Fettsäuren (NEFA) und [uni03B2]-Hydroxybutyrat (BHB); Rückenfettdicke; Milchleistung; Daten zur Kalbung; Laktationszahl; Kuhvater; Trächtigkeitsdauer; Erstkalbealter; Trockenstehdauer; Fruchtbarkeitskennzahlen der Vorlaktation sowie Erkrankungen in der Trockenstehphase und bis 3 Tage post partum. Die Daten wurden mithilfe der Varianzanalyse, Korrelationsanalyse sowie der multiplen linearen Regressionsanalyse auf Zusammenhänge und Einflussfaktoren stufenweise ausgewertet. Ergebnisse: Die mittlere Kalziumkonzentration betrug 2386 mg/l (Standardabweichung = 550 mg/l), wobei der Wert bei Färsen 148,5 mg/l höher lag als bei Kühen. Als relevante Einflussfaktoren ergaben sich die mittlere Tagesmilchmenge der ersten Laktationswoche und die Rückenfettdicke zum Zeitpunkt des Trockenstellens. Der Zusammenhang zur Milchmenge war negativ, was für einen Verdünnungseffekt spricht. Eine Zunahme der Rückenfettdicke bewirkte eine Erhöhung der Kalziumkonzentration im Kolostrum. Zusammen erklärten beide Faktoren 25% der Variabilität der Kolostrumkal ziumkonzentration. Lakta -tionszahl und Kalziumkonzentration im Blut waren keine signifikanten Einflussfaktoren. Schlussfolgerung und klinische Relevanz: Die Hypothesen wurden widerlegt. Es gibt keinen Zusammenhang zur peripartalen Serumkalziumkonzentration und die Laktationszahl ist kein relevanter Einflussfaktor. Die Kalziumkonzentration im Kolostrum hat eine große individuelle Spannweite. Eine Beeinflussung über die Milchmengeneinsatzleistung und die Rückenfettdicke ist möglich, aber im Hinblick auf die Gebärpareseprophylaxe ohne Relevanz.
Management der Trockensteh- und Transitphase von Milchkühen in Boxenlaufställen in Niedersachsen
Authors: Hoedemaker Martina , Oetting-Neumann Pamela
Published: September 2017

Gegenstand und Ziel: Aufzeigen der Haltung und des Managements von Milchkühen in der Trockensteh- und Transitphase in Betrieben unterschiedlicher Größe in Niedersachsen. Material und Methode: In 51 Milchkuhbetrieben erfolgte mittels Fragebogen eine Erhebung zu Tierhaltung und Management in den Kategorien allgemeine Betriebsdaten/Tierbestand, Stallform und Haltung der melkenden Kühe, der trockenstehenden Kühe und Transitkühe sowie der Nachzucht, Weidehaltung, Fütterung, Tiergesundheit und Prophylaxe. Bei einer Begehung wurden weitere Daten zum Tierkomfort erhoben. Ergebnisse: Die Tiere, hauptsächlich Deutsche-Holstein-Rinder, wurden überwiegend in dreireihigen Liegeboxenlaufställen (74%) mit Tiefboxen (47%) und ohne Aufteilung der melkenden Kühe in Leistungsgruppen (59%) gehalten. Die Trockensteher waren am häufigsten in zwei Gruppen unter teilt (68%) und wurden überwiegend in Liegeboxenlaufställen gehalten (68%). Diese Stallform dominierte auch bei der weiblichen Nachzucht (67%), die in den meisten Betrieben nach Reproduktionsstand in Gruppen aufgeteilt war (74%). Keinerlei Weidehaltung fand in 29% der Betriebe statt. In 80% der Betriebe erhielten die Tiere eine aufgewertete Mischration mit Kraftfutterergänzung durch Transponder und 68% der Betriebe praktizierten eine zweiphasige Fütterung der Trockensteher. Als häufigste Gesundheitsprobleme wurden Gliedmaßen- und Klauenprobleme mit 61% genannt. In 21% der Betriebe erfolgte eine Ketoseprophylaxe, in 12% eine Milchfieberprophylaxe, jeweils für jedes Tier rund um die Kalbung. Schlussfolgerung und klinische Relevanz: Haltung und Management in den Betrieben differieren stark und bedürfen zum Teil einer Optimierung in den Stallkonzepten, den Einteilungen nach Leistungsgruppen und deren Fütterung sowie in der tierärztlichen Beratung bei Gesundheitsproblemen und Prophylaxemaßnahmen.
Vorkommen der interstitiellen Nephritis bei Schweinen
Authors: Freitag Mechthild , Baumgärtner Wolfgang , Spiekermeier Ines
Published: September 2017

Gegenstand und Ziel: Die interstitielle Nephritis als eine Form renaler Erkrankungen tritt bei Schweinen häufig auf. Die nur wenigen Forschungsarbeiten auf diesem Gebiet machen eine weitere Erforschung von Prävalenz und Ätiologie dieser Erkrankung notwendig. Material und Methoden: Insgesamt 169 Nieren konventionell und ökologisch gehaltenener Schweine wurden am Schlachthof zufällig ausgewählt und bezüglich des Entzündungsgrades und des Auftretens von Entzündungszellen untersucht. Des Weiteren wurden die Proben mittels Immunhistologie und In-situ-Hybridisierung auf porzines Circovirus Typ 2 (PCV2) als infektiöses Agens untersucht. Ergebnisse: Alle untersuchten Nieren wiesen eine geringgradige Form der interstitiellen Nephritis auf und als Entzündungszellen fanden sich Lymphozyten, Makrophagen, Plasmazellen, eosinophile und neutrophile Granulozyten in unterschiedlichen Häufigkeiten. Hinsichtlich Entzündungsgrad und Auftreten von Entzündungszellen ergaben sich in Nieren von Schweinen der beiden Haltungsformen signifikante (p ≤ 0,0001) Unterschiede. Ökologisch gehaltene Schweine zeigten im Vergleich zu konventionell gehaltenen Tieren signifikant (p ≤ 0,0001) häufiger eine geringgradige Form der Nephritis sowie ein signifikant (p ≤ 0,0001) häufigeres Vorkommen von Lymphozyten und Makrophagen. Bei Schweinen aus konventioneller Haltung bestand im Vergleich signifikant (p ≤ 0,0001) häufiger eine geringgradige bis mittelgradige Nephritis und es lagen signifikant (p ≤ 0,0001) häufiger Lymphozyten, Plasmazellen, Makrophagen sowie neutrophile Granulozyten vor. Nur in der Niere eines Tieres ließ sich DNS von PCV2 nachweisen. Schlussfolgerung: Die interstitielle Nephritis trat bei ökologisch und konventionellen Schweinen auf. PCV2 konnte als bedeutendes Pathogen für die interstitielle Nephritis bei Schlachtschweinen ausgeschlossen werden. Klinische Relevanz: Aufgrund der hohen Prävalenz der interstitiellen Nephritis und der unbekannten Ursache sind weitere Untersuchungen sinnvoll, um klinische Relevanz und Pathogenese weiter einzugrenzen.
Model-based interpretation of undrained creep instability in loose sands
Authors: Marinelli F. , Pisanò F. , Di Prisco C. , Buscarnera G.
Published: September 2017

Evidence shows that in the presence of extended stages of undrained creep, loose sands may approach liquefaction instabilities with a non-negligible time lag with respect to the application of loading. In this paper, a mechanical interpretation of such delayed failure events is provided by using stability criteria for rate-dependent materials. For this purpose, a viscoplastic constitutive law for sands has been calibrated to replicate delayed failure processes documented in the literature. To explain the origin of the transition from stable to unstable creep, the model predictions have been inspected from a mathematical standpoint and a strategy to evaluate the time required for the initiation of failure has been provided. The analyses show that the acceleration of the creep strains anticipates the sharp increase in the rate of pore water pressure, thus constituting a precursor to runaway failure. Furthermore, the computed stresses at which the two variables accelerate are located in proximity of the instability line for static liquefaction, with a shift from it that depends on the rate of loading prior to creep and the soil viscosity. These findings provide support to understand the interplay between rate-dependent soil properties and delayed liquefaction by offering a new conceptual platform to interpret the temporal evolution of flow failures observed under field or laboratory conditions.
KONDISI GEOMORFOLOGI DAN KARAKTERISTIK SEDIMEN DASAR LAUT DI WILAYAH PERAIRAN SEBAGIN UNTUK EVALUASI TAPAK PLTN DI BANGKA SELATAN
Authors: Yuliastuti Yuliastuti , Susiati Heni , Budi Susilo Yarianto Sugeng
Published: September 2017

ABSTRAK KONDISI GEOMORFOLOGI DAN KARAKTERISTIK SEDIMEN DASAR LAUT DI WILAYAH PESISIR PERAIRAN SEBAGIN UNTUK EVALUASI TAPAK PLTN DI BANGKA SELATAN. Telah dilakukan penelitian mengenai kondisi geomorfologi dan karakteristik sedimen dasar laut di wilayah perairan sebagian, Bangka Selatan. Informasi geomorfologi dasar laut sangat berguna dalam hal interpretasi struktur-struktur geologi yang berada di dasar laut. Sedangkan informasi karakteristik sedimen dasar laut bermanfaat untuk memberikan gambaran perlapisan batuan dasar laut dalam kaitannya dengan kestabilan tapak PLTN terkait aspek kegempaan dan penentuan posisi water intake. Penelitian ini bertujuan untuk mengevaluasi kondisi geomorfologi dan karakterisasi sedimen dasar laut di perairan Sebagin, Bangka Selatan. Metodologi yang dipakai untuk mengevaluasi kondisi geomorfologi dasar laut adalah Multi Beam Echo Sounder (MBES) dan Single Beam Echo Sounder (SBES). Sedangkan untuk karakterisasi sedimen dasar laut dilakukan dengan pengukuran seismik refleksi resolusi tinggi menggunakan sub bottom profiling (SBP) dan uji sampel sedimen di daerah penelitian. Hasil penelitian menunjukkan bahwa daerah penelitian merupakan perairan dangkal dengan kedalaman 1- 59 m. Profil geomorfologi dasar laut daerah penelitian cenderung tidak beraturan dan berdasarkan interpretasi seismik tidak ditemukan adanya patahan. Hasil analisis sedimen dasar laut menunjukkan bahwa, distribusi lumpur mendominasi daerah perairan calon tapak PLTN. Kata Kunci : geomorfologi, tapak PLTN, sedimen, sub bottom profile.   ABSTRACT GEOMORPHOLOGICAL CONDITION AND SEA BOTTOM SEDIMENT CHARACTERISTICS OF SEBAGIN COAST FOR NPP SITE EVALUATION IN SOUTH BANGKA. Study on geomorphological condition and sea bottom sediment in the coastal area of Sebagin, South Bangka Regency, Bangka Belitung Province has been performed. Geomorphological of the seabed was valuable to identify geological structures that exist on the seabed layers. Whereas, sediments seabed characteristics was useful to provide portrait of seabed layer due to the stability of NPP site concerning the seismic aspect and the determination of water intake position. The objective of the study was to evaluate geomorphological condition and sea bed sediment characteristics in the South Bangka sea. Methodology used for evaluating geomorphological of the sea bed were Multi Beam Echo Sounder (MBES) and Single Beam Echo Sounder (SBES). While for sea bottom sediment characteristics, SBP together with sediment sample analysis were used. The result of the study showed that the study area was a shallow water sea with a depth range of 1-59 m. Geomorphological profile of the sea bed tend to be irregular and based on the seismic interpretation, there were no fault exists. Result analysis on the sea bottom sediment showed that clay distribution dominated the study area. Keywords: geomorphology, NPP site, sediment, sub bottom profile.
Aplikasi Penginderaan Jauh Dalam Pemetaan Penggunaan Lahan Detil Tapak RDE, PUSPIPTEK Serpong
Authors: Susiati Heni , Subagio Habib
Published: September 2017

Telah dilakukan pemetaan tutupan lahan dan perkembangannya dalam skala detil (1 : 5.000) dengan radius 5 km dari pusat tapak rencana pembangunan Reaktor Daya Eksperimental (RDE) di Kawasan Nuklir Serpong (KNS), PUSPIPTEK Serpong. Tujuan penelitian adalah untuk membuat database penggunaan lahan skala detil 1:5.000 sebagai persiapan dalam rencana pembangunan RDE dan melengkapi peta tutupan lahan skala 1: 10.000. Metode penelitian dilakukan dalam beberapa tahap, yaitu pengumpulandan pengolahan data citra, ground check lapangan, analisis penggunaan lahan radius 300-500 m, radius 1,2,3,4, dan 5 km dari tapak RDE, serta perubahan penggunaan lahan tahun 2014-2015. Pengolahan citra satelit dilakukan di Pusat Pemetaan dan Tataruang, Badan Informasi Geospasial (BIG). Pengolahan data menggunakan program ArcGis dan Er Mapper, sedangkan analisis data citra satelit menggunakan Image Analysis yang merupakan salah satu tool dalam ArcGis. Hasil penelitian menunjukkan bahwa tutupan lahan KNS setelah radius 3 km merupakan pemukiman yang padat di berbagai tempat. Perubahan penggunaan lahan pada tahun 201 4-201 5 menunjukkan bahwa terjadi perkembangan pesat pemukiman ditunjukkan dengan peningkatan luasan pemukiman di bagian Utara – Timur kawasan PUSPIPTEK.
A tutoria virtual no processo de ensino e aprendizagem de estudantes na disciplina de Estágio Supervisionado em Educação Infantil
Authors: Martins Andressa De Oliveira , Zanotto Luana , Sommerhalder Aline
Published: September 2017

A pesquisa foi realizada na disciplina “Estágio Supervisionado de Educação Infantil” do curso de Pedagogia a distância de uma universidade federal. Objetivou identificar e compreender, na perspectiva de tutores virtuais, as funções elementares exercidas no processo de ensino e aprendizagem de estudantes. Aplicou-se questionário aberto para quatro tutoras. Os resultados revelaram a tutoria como apoio principal ao acompanhamento das aprendizagens dos estudantes, motivando-os para investimento nos estudos e incentivando-os a refletirem sobre a realidade e a teorizarem a prática profissional em estágio. A tutoria se imbricou na relação dialógica e de horizontalidade do processo, sendo necessário ter disponibilidade para o diálogo com os estudantes.
Orientações legais, discursos e práticas no 1º ano do Ensino Fundamental: fragilidades na formação e ausência do brincar
Authors: Hirsch de Medeiros Michele , Mesomo Lira Aliandra Cristina
Published: September 2017

O objetivo desse texto é refletir acerca das contradições evidenciadas no texto legal, no discurso dos professores e na prática docente com crianças de 1º ano no que diz respeito ao brincar. As reflexões aqui apresentadas são um recorte da pesquisa desenvolvida em curso de Mestrado, que partiu de estudos teóricos e documentos que tratam do ensino fundamental de 9 anos e o brincar, e coletou dados por meio de observações de práticas, entrevistas com professores, coordenadores pedagógicos e diretores das instituições e turmas observadas, bem como entrevista-conversa com as crianças. Foi possível compreender que as orientações legais não foram acompanhadas por efetiva formação, o que configura um cotidiano com a ausência do brincar.
Universidade e Escola da Educação Básica: um recorte com base na formação continuada de gestores escolares
Authors: Silva Barbosa José Márcio , Arruda Eucidio Pimenta , Andrade Vaz de Mello Rita Márcia
Published: September 2017

O artigo se inscreve no contexto atual de expansão e interiorização do Programa Nacional Escola de Gestores da Educação Básica Pública em duas Universidades públicas federais no estado de Minas Gerais. O objetivo é contribuir para o debate e sobre a importância do compromisso das Universidades no que tange à formação continuada de gestores escolares e possíveis práticas efetivas no trabalho pedagógico escolar. A partir da investigação bibliográfica e pelo levantamento denota-se que o desafio atual entre a parceria PNEGEB, Universidade e Escola, é priorizar a relação teoria-prática com base na vivência e na realidade dos gestores egressos do curso na busca de qualidade social para a educação básica pública.
Literatura infantil: mediar práticas de leitura envolvendo a cultura escrita e a visualidade
Authors: Nunes Marília Forgearini
Published: September 2017

A multimodalidade na constituição dos textos nem sempre é considerada nas ações de leitura propostas pela escola básica. A literatura infantil é um texto multimodal que pode ser lido considerando essa constituição e desenvolvendo a leitura tanto verbal quanto visual. Nosso objetivo é ampliar o conceito de leitura para outras linguagens além da verbal, definir o que significa mediar e, analisar um texto literário infantil verso-visual para mediar a sua leitura pretendendo o envolvimento e a desenvoltura leitora tanto com a cultura escrita quanto com a visualidade. O referencial teórico para compreender a constituição do texto e que interfere no nosso conceito de leitura e de mediação é a semiótica discursiva ou de base francesa.
O PIBID e a escola como espaço de aprendizagem da profissão docente
Authors: Brostolin Marta Regina , Cardoso de Souza dos Santos Thais
Published: September 2017

Este artigo é  um recorte de uma pesquisa qualitativa realizada com professores da educação básica que trabalhavam com o Subprojeto do curso de Pedagogia do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) de uma universidade pública de Campo Grande, MS. Utiliza-se como aporte teórico Libâneo (2010), Gatti (2003), Imbernón (2006 e 2010),  García (1999),  Canário (1998), Nóvoa (1995, 1999), Tardif (2000, 2002) entre outros. Constatou-se que  os sujeitos da pesquisa, os professores que estão a mais tempo na profissão, bem como os acadêmicos bolsitas inseridos no ambiente escolar reconhecem a escola como principal lócus da profissão docente, onde ocorre a prática efetiva dos aprendizados teóricos.
How the Word Gap Argument Negatively Impacts Young Children of Latinx Immigrants' Conceptualizations of Learning
Authors: Adair Jennifer Keys , Colegrove Kiyomi Sánchez-Suzuki , McManus Molly E.
Published: September 2017

Early childhood education in grades preK–3 continues to contribute to future school success. Discrimination, however, can still be an obstacle for many children of Latinx immigrants because they often receive less sophisticated and dynamic learning experiences than their white, native-born peers. In this article, Jennifer Keys Adair, Kiyomi Sánchez-Suzuki Colegrove, and Molly E. McManus detail how this type of educational discrimination is perpetuated by educators' acceptance of the “word gap” discourse. Drawing on empirical work with more than two hundred superintendents, administrators, teachers, parents, and young children, they recount how caring, experienced educators explained that Latinx immigrant students could not handle dynamic, agentic learning experiences because they lacked vocabulary and how the children in those classrooms said that learning required still, obedient, and quiet bodies. Rather than blaming educators, the authors share this empirical evidence to demonstrate the harm that can come from denying young children a range of sophisticated learning experiences, especially when institutionally and publicly justified by deficit-oriented research and thinking. Using the work of Charles Mills, the authors argue that such a denial of experience to children of Latinx immigrants and other marginalized communities is discriminatory and, too often, the status quo.
Eva Vacuum-Formed Alternative Splinting of Alveolar Fractures in Primary Dentition: A Case Report
Authors: Chatzidimitriou Konstantina , Lygidakis Nikos N , Lygidakis Nick A
Published: September 2017

Alveolar fractures treatment includes repositioning of displaced segments and splinting. In children, splinting procedures may occasionally present clinical problems resulting from fewer teeth available for splinting or presence of occlusal disturbances. An alternative clinical approach for splinting in alveolar fractures of primary dentition is described. Clinical case: A 4.5-year-old girl was referred to our clinic 8 hours after a fall accident. Clinical examination revealed mandibular alveolar process segmental fracture in the right canine area with frontal dislodgement of the labial cortical bone resulting to occluding inability. The area was anaesthetized, cleaned and the dislodged bone was manually repositioned, followed by an EVA copolymer splint for fixation as a result of patient's deep bite impeding regular wire-composite splint. The cap splint that was fabricated on a cast made after an alginate impression, was set on the mandibular dentition and immobilized in the primary molars with acid-etch adhesive and flowable resin composite. Following splint removal after 4 weeks and follow-up visits, successful healing was observed clinically and radiographically with no pathological signs and symptoms. Conclusion: The described alternative splinting method in alveolar fractures of primary dentition is a valuable clinical tool for peediatric dentists, easily accepted by children in cases where regular splinting methods cannot be used.
Effect of Qmix and Other Irrigants on Dentin Adhesives in Pulp Chambers of Primary Teeth: SEM Study
Authors: Kapoor Sidharth , Manuja Naveen , Chaudhary Seema , Kaur Harsimran , TR Chaitra , Sinha Ashish Amit
Published: September 2017

Objective: To compare the effect of different endodontic irrigants on microleakage of adhesives used within pulp chamber of primary molars. Study Design: 72 Primary molars were divided into 6 groups, according to 3 irrigants and 2 adhesives used. After de-roofing the pulp chamber, pulp was extirpated. In 36 samples, pulp chambers were bonded with Xeno V+ after irrigation with either QMix (Group1); 17%EDTA+5%NaOCl (Group2) or normal saline (Group3) and in other half samples, pulp chambers were bonded with SinglebondUniversal after irrigation with either QMix (Group 4); 17%EDTA+5% NaOCl (Group5) or normal saline (Group 6). All the samples were restored with Filtek Z350. Ten teeth from each group were assessed for dye penetration. Two samples in each group were viewed under scanning electron microscope. Data was statistically analyzed using Mann–Whitney and Kruskal Wallis tests at a significance level of P < 0.05. Results: Mean microleakage scores were: Group 1-1.5±0.70, Group 2-1.6±.51, Group 3-2.4±0.96, Group 4-1.2±0.42, Group 5-1.2±0.42, Group 6-1.1±0.32. Conclusions: Irrigation with QMix significantly reduced the microleakage of XenoV+ but had no significant effect on microleakage of SinglebondUniversal. Irrigation with EDTA/NaOCl or QMix had no detrimental effect on the sealing ability of either of the adhesive tested.
Respon Fisiologis dan Kualitas Susu Sapi Perah Friesian Holstein pada Musim Kemarau Panjang di Dataran Tinggi
Authors: Mariana Elmy , Hadi Didik Nurul , Agustin Nur Qoim
Published: September 2017

ABSTRAK. Tujuan dari penelitian ini adalah untuk mempelajari respon fisiologi, produksi dan kualitas susu sapi perah Frisian Holstein pada akhir musim kemarau panjang di Balai Pengembangan Ternak Sapi Perah dan Hijauan Makanan Ternak (BPT-SP HMT) Cikole, Lembang, Bandung.  Penentuan sampel menggunakan metode purposive sampling. Parameter mikroklimat yang diamati antara lain adalah temperatur lingkungan, kelembaban relatif, kecepatan angin, radiasi sinar matahari dalam kandang dan Temperature-Humidity Index (THI). Respon fisiologis yang diamati meliputi suhu rektal, suhu kulit, suhu tubuh, frekuensi respirasi dan denyut jantung. Nilai rerata THI (73.93±5.51) menunjukkan sapi perah berada dalam kondisi  stress ringan. Nilai rerata dari suhu rektal, suhu kulit, suhu tubuh, frekuensi respirasi dan denyut jantung secara berurutan 37.94±0.20°C; 32.15±1.25°C; 37.13±0.32°C; 39.13 ±3.00 dan 79.74±6.19. Nilai rerata persentase bahan kering, lemak dan protein susu secara berurutan 10,19 ± 0,72, 2,14 ± 0,38 dan 2,50 ± 0,32. Temperatur lingkungan yang tinggi  mempengaruhi respon fisiologis antara lain peningkatan denyut jantung yang lebih tinggi dari normal dan kualitas susu yang lebih rendah.   (Physiological responses and milk qualities of holstein friesian during long dry season at high altitude)ABSTRACT. The objectives of this study were to evaluate physiological responses and milk qualities of dairy cows in Balai Pengembangan Ternak Sapi Perah dan Hijauan Makanan Ternak (BPT-SP HMT) Cikole West Bandung at the end of long dry season. Samples were determined by using purposive sampling method. Microclimate parameters  were included  ambient temperature, relative humidity, air velocity, solar radiation and temperature-humidity index (THI). Physiological responses consisted of rectal temperature, skin temperature, body temperature, respiration rate and pulse rate. The mean value of THI (73.93±5.51) showed that dairy cows suffered by heat stress. The mean value of rectal temperature, skin temperature, body temperature, respiration rate and pulse rate were 37.94±0.20°C; 32.15±1.25°C; 37.13±0.32°C; 39.13±3.00 and 79.74±6.19 consecutively. The average percentage value of dry matter, fat and protein content in milk were 10.19±0.72, 2.14±0.38 and 2.50±0.32. High ambient temperature and low relative humidity affected physiological responses such as pulse rate that higher than normal,  and  lower milk yield.
Pengaruh Pemberian Pakan dengan Sumber Protein Berbeda terhadap Efisiensi Penggunaan Protein Ayam Lokal Persilangan
Authors: Varianti Nunik Ita , Atmomarsono Umiyati , Mahfudz Luthfi Djauhari
Published: September 2017

ABSTRAK. Penelitian ini bertujuan untuk mengkaji pengaruh pemberian pakan dengan sumber protein berbeda terhadap efisiensi penggunaan protein ayam lokal persilangan. Materi penelitian adalah 126 ekor ayam lokal persilangan (unsexed) umur 2 minggu, bobot badan 129,02 ± 6,34 g. Penelitian menggunakan rancangan acak lengkap (RAL), dengan 3 perlakuan, serta 7 ulangan, dan setiap unit percobaan terdiri dari 6 ekor ayam. Perlakuannya antara lain T1: 2 sumber protein (bungkil kedelai, tepung ikan); T2: 3 sumber protein (bungkil kedelai, tepung ikan, MBM (Meat Bone Meal)); T3: 4 sumber protein (bungkil kedelai, tepung ikan, Meat Bone Meal (MBM), Poultry Meat Meal (PMM)). Pakan sumber energi (jagung dan bekatul), pakan sumber mineral CaCo3. Pakan diberikan secara bebas memilih, ad libitum dan dalam benruk mash. Data yang diperoleh dianalisis menggunakan ANOVA (Analysis of Variance) dengan uji F taraf 5%, dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa pemberian pakan dengan sumber protein berpengaruh nyata (p0,05) meningkatkan konsumsi protein (T1: 7,65c; T2: 9,57b; T3: 11,40a) g/ekor/hari, menurunkan rasio efisiensi protein (T1: 1,65a; T2: 1,42b; T3: 1,40b), dan meningkatkan asupan protein (T1: 5,82c; T2: 7,30b; T3: 8,82a) g/ekor/hari. Disimpulkan bahwa pemberian pakan dengan sumber protein (bungkil kedelai dan tepung ikan) dapat meningkatkan efisiensi protein ayam lokal persilangan. (The influence of different protein source on efficiency protein of crossbred local chicken) ABSTRACT. This research was aimed to determine the influence of different protein source on protein utilization of Crossbred Local Chicken. Using 126 Crossbred Local Chicken unsexed 2 weeks old with the average body weight 129,02 ± 6,34 g. Completely randomized design with 3 treatments and 7 replication applied, each experimental unit consistent of 6 chickens. The treatment are T1: 2 protein source (soybean meal, fish meal); T2: 3 protein source (soybean meal, fish meal, meat bone meal); T3: 4 protein source (soybean meal, fish meal, meat bone meal. poultry meat meal). Feed energy source (corn and rice bran) and mineral source (CaCo3). Feed given with method free choice feeding, ad libitum, mash. The data obtained were analyzed using Analysis of Variance F-test with level 5% and Duncan test. The research showed that different protein source significantly (P0,05), increase protein consumption (T1: 7,65c; T2: 9,57b; T3: 11,40a) g/day, descreased ratio protein efficiency (T1: 1,65a; T2: 1,42b; T3: 1,40b) and increase protein intake (T1: 5,82c; T2: 7,30b; T3: 8,82a) g/day. As a cconclusion that feeding with soybean meal and fish meal as protein source able to improve protein efficiency of crossbred local chicken.
Analisa Nilai Tambah Dan Kelayakan Agroindustri Nata De Coco Di Kabupaten Ketapang Kalimantan Barat
Authors: Wardanu Adha Panca , Uliyanti Uliyanti
Published: September 2017

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