bluuebunny/crossref_metadata_2025 huggingface dataset:
ESSENTIAL BASIS OF INNOVATIVE ACTIVITY IN THE CONTEXT OF RENEWABLE ENERGY DEVELOPMENT
Authors: Matvieieva Y. , Saher L. , Vakulenko I. , Petryna V.
Published: October 2022

Environmental degradation, climate change, the greenhouse effect and other negative consequences are the key problems of humanity. And one of the ways to solve these problems is the development of renewable energy based on the use of innovative technologies.In the study of the impact of the parameters of innovative development on renewable energy, was performed bibliometric analysis using such software as VOSviewer, Web of Science, Scopus Tools Analysis and Google Trends. A sample of papers from 2000-2021 from the Scopus® database, which contains bibliographic information about scientific publications in peer-reviewed journals, books and conferences, was selected for data analysis. The results of the analysis based on the Scopus® database tools confirmed the hypothesis of a growing trend of publications that examining the issues of innovation in the context of renewable energy development. With the help of VOSviewer (version 1.6.18) were identified four clusters. These clusters are: types of resources, renewable energy, sustainable development, innovation. The second cluster (renewable energy) focuses on the terms with the strongest communication power. The article found that research in the field of innovation and development of renewable energy is carried out by different countries. However, these issues are most actively studied in the following countries: the United States, China and the United Kingdom. A separate dynamics of the number of publications was studied in 11 countries, of which 10 countries are leaders in the number of publications. Data from Ukraine are analyzed also. The dynamics of the number of publications in each country varies. For example, the dynamics of publications in China is growing rapidly in 2021. In the United States, the dynamics of publications are characterized as fluctuations. At the same time, in 2021 the country has the largest number of works among all the studied countries. The dynamic of publications in the UK is characterized by fluctuations with the significant decrease in 2021. In Ukraine, the indicators began to appear in 2013. But in 2021 their number increases significantly. The Google Trends tool has identified public interest in the topic. The interest of business and industry is considered separately. It was found that in the first case, the interest is more in innovation. Business and industry are paying more attention to the development of renewable energy sources.
Relative defects in relative theories: Trapped higher-form symmetries and irregular punctures in class S
Authors: Bhardwaj Lakshya , Giacomelli Simone , Hübner Max , Schäfer-Nameki Sakura
Published: October 2022

A relative theory is a boundary condition of a higher-dimensional
topological quantum field theory (TQFT), and carries a non-trivial
defect group formed by mutually non-local defects living in the relative
theory. Prime examples are 6d6d\mathcal{N}=(2,0)𝒩=(2,0)
theories that are boundary conditions of 7d7d
TQFTs, with the defect group arising from surface defects. In this
paper, we study codimension-two defects in
6d6d\mathcal{N}=(2,0)𝒩=(2,0)
theories, and find that the line defects living inside these
codimension-two defects are mutually non-local and hence also form a
defect group. Thus, codimension-two defects in a
6d6d\mathcal{N}=(2,0)𝒩=(2,0)
theory are relative defects living inside a relative theory. These
relative defects provide boundary conditions for topological defects of
the 7d7d
bulk TQFT. A codimension-two defect carrying a non-trivial defect group
acts as an irregular puncture when used in the construction of
4d4d\mathcal{N}=2𝒩=2
Class S theories. The defect group associated to such an irregular
puncture provides extra “trapped” contributions to the 1-form symmetries
of the resulting Class S theories. We determine the defect groups
associated to large classes of both conformal and non-conformal
irregular punctures. Along the way, we discover many new classes of
irregular punctures. A key role in the analysis of defect groups is
played by two different geometric descriptions of the punctures in Type
IIB string theory: one provided by isolated hypersurface singularities
in Calabi-Yau threefolds, and the other provided by ALE fibrations with
monodromies.
The hitchhiker's guide to 4d $\mathcal{N}=2$ superconformal field theories
Authors: Akhond Mohammad , Arias Tamargo Guillermo , Mininno Alessandro , Sun Hao-Yu , Sun Zhengdi , Wang Yifan , Xu Fengjun
Published: October 2022

Superconformal field theory with \mathcal{N}=2𝒩=2
supersymmetry in four dimensional spacetime provides a prime playground
to study strongly coupled phenomena in quantum field theory. Its rigid
structure ensures valuable analytic control over non-perturbative
effects, yet the theory is still flexible enough to incorporate a large
landscape of quantum systems. Here we aim to offer a guidebook to
fundamental features of the 4d \mathcal{N}=2𝒩=2
superconformal field theories and basic tools to construct them in
string/M-/F-theory. The content is based on a series of lectures at the Quantum Field Theories and Geometry School in July 2020.
IMPROVING THE LEAST MASTERED COMPETENCIES ON NUMBER AND NUMBER SENSE OF GRADE 7 LEARNERS
Authors:   Department of Education, Schools Division of Sorsogon City., Michael G. Domanais , Ritzelda A. Deri ,   Sorsogon State University Graduate School, Sorsogon City, Sorsogon.
Published: October 2022

Monitoring the quality of Mathematics education and taking actions to address its challenges is one of the many ways in attaining a countrys growth and development. The national mean percentage score (MPS) of Filipino learners in the National Achievement Test (NAT) for Grade 6 and Year IV along Mathematics subtest is still not yet at 75% passing rate. Thus, the study identified the proficiency level of the Grade 7 learners least mastered competencies along topics in Numbers and Number Sense with an end view of improving their proficiency levels. A one group pretest-posttest design type of research using a test instrument with a computed reliability coefficient of 0.83 was utilized. Moreover, the developed lessons on Number and Number Sense served as the intervention in improving the competencies of the respondents. Generally, there were significant increases on the proficiency level of the students after the implementation of the lessons, however, the fact that the learners were still low proficient on conceptual understanding and procedural skills along the identified competencies is undeniable. Hence, continuous monitoring of the learners focusing on the identified competencies maybe considered as part of the pre-evaluation of teachers to their grade 7 classes to integrate reinforcement in the improvement of the learners proficiency in the identified least mastered competencies.
COVID-19 and domestic trade in Bulgaria
Authors: Todorov Lyubomir
Published: October 2022

Domestic trade is an essential contributor to economic growth and an indicator of the people’s welfare. It is vulnerable to the COVID-19 crisis due to the pandemic itself and the government’s measures against it. An accurate estimation of the pandemic influence on domestic trade is needed for effective economic intervention in support of the economic recovery and improvement of the well-being of the population. The aim of this paper is to estimate the magnitude and timing of the COVID-19 impact on domestic trade in Bulgaria. The data used in the study covered the period 2000–2020 with monthly data for the indicator “Turnover for wholesale and retail trade and repair of motor vehicles and motorcycles in Bulgaria.” This paper employed unit root tests, autocorrelation function analysis, building, estimating, forecasting ARIMA and ARCH models, and intervention analysis. The results revealed that Bulgarian domestic trade followed the difference-stationary process as unit root tests failed to reject the random walk hypothesis. The COVID-19 impact on domestic trade proved to be long-lasting and has permanently decreased its level since March 2020. The timing of the impact coincided with the government’s measures against the pandemic. The drop in the volume of domestic trade was substantial and estimated at 19.3%. Following the nature of domestic trade, determined and decisive intervention is necessary if the Bulgarian government seeks to expand domestic demand and successfully procure economic recovery.
Research on the release relationship between dissolved oxygen (DO) and total dissolved gas (TDG) in standing water
Authors: Yao Yuanbo , Yang Huixia , Wang Yunyun
Published: October 2022

Supersaturation of dissolved oxygen (DO) and total dissolved gas (TDG) is generated by high dam discharge, excess oxygen production in photosynthesis and increasing temperature in water, which may directly lead to fish suffering from ‘gas bubble disease’ or death. In this paper, under a series of experimental aeration conditions in standing water, it was concluded that aeration had a positively promoting effect on releases of supersaturated DO and TDG, while aeration aperture and aeration depth had inhibitory effects on them. For single factor analysis, aeration had the greatest effect on the release of DO and TDG, the second effect on DO was that of aeration depth and the smallest effect was that of aeration aperture, but the second effect on TDG was that of aeration aperture and the smallest effect was that of aeration depth. Most importantly, the release coefficient of DO was greater than that of TDG, and a quantitative relationship between the release coefficient of DO and TDG and aeration conditions, respectively, was established. An exponential function relationship of the release coefficients of DO and TDG was also established. The results of the research have important guiding significance and theoretical value for reducing the harm caused by supersaturated DO and TDG.
Upregulation of Connexins in the Rat Hippocampal and Cortical Neurons
Following Blockade of NMDA Receptors During Postnatal Development
Authors: Kourosh-Arami Masoumeh , Soleimani Mansoureh , Joghataei Mohammad Taghi , Mosleh Masoumeh , Hayat Parisa , Komaki Alireza
Published: October 2022

Background:

Interneural gap junctional coupling represents neural development that
decreases during the postnatal period. The decrease of gap junction function coincides with the main
period of chemical synapse creation and increment of synaptic activity during postnatal weeks 1 to 3.

Methods:

Here, we have assessed the role of chemical synapses on connexin (Cx) expression in
neurons and glial cells of hippocampal and cortical neurons. We characterized the impact of NMDA
receptors blockade on the expression of Cx36 and Cx43 proteins by western blot analysis in postnatal
day (PND)14 and PND28. MK801 was injected subcutaneously from the first day of birth until 14 or 28
days, depending on the experimental groups. Saline was injected in the same volumes in the control
group.

Results:

Early postnatal blockade of the NMDA subtype of glutamate receptors by the non-competitive
antagonist dizocilpine maleate (MK801) arrested the developmental reduction in gap junctions during
the initial postnatal weeks. Expression of Cx43 declined in PND28 compared to PND14 in visual cortex
(VC) neurons. Also, we found that the expression of Cx36 and Cx43 augmented in the rats' VC in
PND28 following the blockade of NMDA receptors. Expression of Cx36 declined in PND28 compared
to PND14 in hippocampal neurons. Also, we found that the expression of Cx36 augmented in the rats'
hippocampal neurons in PND14 and PND28 following a blockade of NMDA receptors.

Conclusion:

These results suggest that the postnatal enhancement in glutamatergic synaptic activity is
associated with the loss of gap junctional connections and downregulation of Cx36 and Cx43 between
developing neurons and glial cells.
Associations Between microRNA-related Genetic Polymorphisms and Clinical
Response to Methotrexate in Chinese Rheumatoid Arthritis Patients
Authors: Wen Qin-Wen , Chen Chong-Jing , Zhang Han-Qing , Yu Hang , Zeng Zhen , Jin Ting , Wang Ting-Hui , Qin Wen , Huang Hua , Wu Xiu-Di , Cen Han
Published: October 2022

Background:

Emerging evidence indicates that microRNA (miRNA)-related genetic polymorphisms
are strongly involved in the post-transcriptional regulation of the expression of pharmacokinetics and pharmacodynamics-related genes, therefore contributing to the genetic variability of drug response.

Objective:

To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189
rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to
methotrexate in Chinese rheumatoid arthritis patients.

Methods:

One hundred patients treated with MTX for approximately 3 months were prospectively followed up
to evaluate the clinical response according to European League Against Rheumatism (EULAR) good and moderate response, disease activity score in 28 joint counts - erythrocyte sedimentation rate (DAS28-ESR) low disease activity (LDA) and remission (REM), change in DAS28-ESR (ΔDAS28-ESR) and ΔDAS28-ESR > 0.6.
Genetic polymorphisms were genotyped utilizing the HI-SNP technology.

Results:

Of the 100 patients with a mean age of 52.23 ± 12.71 years, 81 patients were female (81.00%). After
adjusting potential confounders, the major allele of miRNA-5189 rs562929801 was found to be significantly associated with EULAR response (A/A + A/G versus G/G, RR = 0.81, 95% CI = 0.67-0.99, P = 0.04) and
ΔDAS28-ESR > 0.6 under dominant model (A/A + A/G versus G/G, RR = 0.83, 95% CI = 0.71-0.98, P =
0.03). However, nonsignificant evidence was detected for the remaining three miRNA-related genetic polymorphisms in neither univariable analysis nor multivariable analysis.

Conclusion:

Our results indicated that miRNA-5189 rs562929801 was significantly associated with clinical response to MTX, and this association warrants further replication studies with larger sample sizes.
Integrating Network Pharmacology and Experimental Verification to
Investigate the Mechanisms of Shuangshi Tonglin Capsule to Treat Chronic
Prostatitis
Authors: Mao Qian , Zhang Xinyue , Wang Chuan , Liu Jiping , Wang Ziqiang , Wang Bin , Mao Peng , Wei Hao , Wang Baoan
Published: October 2022

Background and Objective:

Chronic prostatitis (CP) is one of the most common
diseases in young and middle-aged men but lacks effective treatment. Shuangshi Tonglin Capsule
(SSTLC) is a clinical drug for the treatment of chronic prostatitis. However, the underlying molecular
mechanisms of SSTLC in treating CP are still unclear. In this study, we researched the underlying
mechanisms of SSTLC in treating chronic prostatitis.

Methods:

The ingredients of SSTLC were received from the TCMSP and BATMAN databases,
and the CP targets were collected based on GeneCards and OMIM. Then, the PPI network and the
“drug-ingredient-target” network map were constructed. GO and KEGG enrichment analyses by
using DAVID. Molecular docking was performed by using AutoDock 4.2 and PyMol. And using
animal experiments to verify the potential effect of SSTLC in CP.

Results:

SSTLC contained 10 herbs, 158 chemical ingredients and 277 targets, 2002, diseaserelated
targets were obtained. Network analysis outcomes indicated that VEGFA, TNF, MAPK1,
EGFR, and MAPK8 are the key targets of SSTLC in treating chronic prostatitis. Furthermore, molecular
docking revealed that quercetin, luteolin, and kaempferol exhibited a strong binding effect.
Animal experimental indicated that SSTLC can reduce the pathological damage to prostate tissue.
And, we found that high-dose SSTLC significantly reduced the level of TNF-α and downregulated
the expression of EGFR, p-p38 and p-ERK1/2 (P<0.05).

Conclusions:

This study determined the pharmacological effects of SSTLC and the potential mechanism
of action on SSTLC to treat CP, it provides a new idea for traditional Chinese medicine to
treat chronic prostatitis.
Chronic Cerebral Hypoperfusion-induced Dysregulations of Hyperpolarization-
activated Cyclic Nucleotide-gated, KCNQ and G Protein-coupled
Inwardly Rectifying Potassium Channels Correlated with Susceptibility
and Unsusceptibility to Anxiety Behaviors
Authors: Luo Pan , Liu Wei , Zhou Mei , Li Youwei , Lin Kuan
Published: October 2022

Background:

Cerebrovascular lesions could induce affective disorders; however, the
depression- and anxiety-related symptoms caused by chronic cerebral hypoperfusion (CCH) and the
roles of different hyperpolarization-activated cyclic nucleotide-gated (HCN), KCNQ and G proteincoupled
inwardly rectifying potassium (GirK) channel subunits in these pathological processes have
been poorly elucidated so far.

Objective:

To investigate the behavioral change and the alteration of HCN, KCNQ, and GirK subunits
in amygdale rats suffering from CCH.

Methods:

Permanent bilateral occlusion of the common carotid arteries was used to induce CCH.
Anxiety and depression levels were assessed by the elevated plus maze test, sucrose preference test
and forced swimming test to classify rats as highly anxious or depressive ‘susceptibility’ vs. ‘unsusceptibility’.
The expression of brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B
(TrKB), HCN1/2, KCNQ2/3, and GirK1/2/3 were quantified by Western blotting.

Results:

The main emotional change caused by 4 weeks of CCH is likely to be anxiety-like behavior
(50%), accompanied by a down-regulation of BDNF and TrKB expression in amygdale. The increase
of HCN1 and decrease of KCNQ3 expression in amygdale may be factors to blame for anxiety-
like symptom caused by CCH, and the increase of KCNQ2 and Girk1 expression in amygdale
may play a role in resilience to the anxiety induced by CCH.

Conclusion:

The different subunits of HCN, KCNQ and GirK channels in amygdale may contribute
to distinct response to aversive stimuli or stress induced by CCH that evokes divergent influences on
anxiety-like behavior in rats.
Apoptin Inhibits Glycolysis and Regulates Autophagy by Targeting
Pyruvate Kinase M2 (PKM2) in Lung Cancer A549 Cells
Authors: Song Gaojie , Shang Chao , Zhu Yilong , Xiu Zhiru , Li Yaru , Yang Xia , Ge Chenchen , Han Jicheng , Jin Ningyi , Li Yiquan , Li Xiao , Fang Jinbo
Published: October 2022

Background:

Pyruvate kinase M2 (PKM2) is a key enzyme in aerobic glycolysis and plays
an important role in tumor energy metabolism and tumor growth. Ad-apoptin, a recombinant oncolytic
adenovirus, can stably express apoptin in tumor cells and selectively causes cell death in tumor cells.

Objective:

The relationship between the anti-tumor function of apoptin, including apoptosis and autophagy
activation, and the energy metabolism of tumor cells has not been clarified

Methods:

In this study, we used the A549 lung cancer cell line to analyze the mechanism of PKM2
involvement in apoptin-mediated cell death in tumor cells. PKM2 expression in lung cancer cells was
detected by Western blot and qRT-PCR. In the PKM2 knockdown and over-expression experiments,
A549 lung cancer cells were treated with Ad-apoptin, and cell viability was determined by the CCK-8
assay and crystal violet staining. Glycolysis was investigated using glucose consumption and lactate
production experiments. Moreover, the effects of Ad-apoptin on autophagy and apoptosis were analyzed
by immunofluorescence using the Annexin v-mCherry staining and by western blot for c-PARP,
p62, and LC3-II proteins. Immunoprecipitation analysis was used to investigate the interaction between
apoptin and PKM2. In addition, following PKM2 knockdown and overexpression, the expression
levels of p-AMPK, p-mTOR, p-ULK1, and p-4E-BP1 proteins in Ad-apoptin treated tumor cells
were analyzed by western blot to investigate the mechanism of apoptin effect on the energy metabolism
of tumor cells. The in vivo antitumor mechanism of apoptin was analyzed by xenograft tumor
inhibition experiment in nude mice and immunohistochemistry of tumors’ tissue.

Results:

As a result, apoptin could target PKM2, inhibit glycolysis and cell proliferation in A549 cells,
and promote autophagy and apoptosis in A549 cells by regulating the PKM2/AMPK/mTOR pathway.

Conclusion:

This study confirmed the necessary role of Ad-apoptin in the energy metabolism of A549
cells.
On Water Synthesis of 3-Aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines using Iodobenzene Diacetate
Authors: Soni Rinku , Aneja Deepak Kumar , Sihag Monika , Rani Neha , Kinger Mayank
Published: October 2022

A simple and green methodology has been developed for the synthesis of 3-aryl-5,7- dimethyl-1,2,4-triazolo[4,3-a]pyrimidines in water. Oxidative cyclization of 4,6-dimethyl-2- pyrimidinylhydrazones of different aldehydes was achieved in good to excellent yield using iodobenzene diacetate at room temperature. High efficiency, easy work-up, short reaction time, non-toxicity of solvent and ambient temperature are the advantages of this methodology.
Adsorption of Diethylstilbestrol Drug into BNNT: DFT/TD-DFT and Spectroscopic
(Excited States, UV/Vis and NMR) Studies
Authors: Hosseinzadeh Maryamossadat , Masoudi Shiva , Masnabadi Nasrin , Azarakhshi Fatemeh
Published: October 2022

Cancer has become a significant universal health problem. Anticancer drugs control the chemicals that sacrifice cancer cells by inhibiting their growth in their cell cycle. Interestingly, as much as boron nitride nanosheets and boron nitride nanotubes are degradable and non-toxic, they can act as suitable drug carriers for antitumor drugs and deliver them into target cells. In the present study, the encapsulation of diethylstilbestrol as an anticancer drug into the boron nitride (8,8) nanotube was investigated for the first time using the density functional theory: M06-2X and the natural bond orbital methods in the gas phase. Using natural bond orbital analysis, the charge transfer between diethylstilbestrol drug and boron nitride nanotubes (8,8)/ diethylstilbestrol complex was explored.
Based on the results obtained from the calculation of encapsulation energy, it was found that the adsorption process was favorable. The interaction effects of diethylstilbestrol drug and boron nitride (8,8) nanotube on the natural bond orbital charge, the chemical shift parameters, and electronic properties were also evaluated. This study revealed that boron nitride (8,8) nanotubes can be a suitable carrier for diethylstilbestrol drug delivery. The ultra violet-visible spectra of diethylstilbestrol drug and the boron nitride (8,8) nanotubes/diethylstilbestrol complex were computed using time-dependent density functional theory (: M06-2X calculations.
Toxicity, Safety, and Pharmacotherapeutic Properties of Ursolic Acid:
Current Status, Challenges, and Future Perspectives against Lung Cancer
Authors: Subramanian Chandrakumar , Solairaja Solaipriya , Dunna Nageswara Rao , Venkatabalasubramanian Sivaramakrishnan
Published: October 2022

Lung cancer is often associated with the second leading cause of mortality in males globally. Despite clinical advancements, their incidence in humans has not decreased. Hence identifying and developing alternative or complementary therapeutic agents with evidence targeting lung cancer is of considerable interest. Ursolic Acid (UA): a dietary flavonoid present in herbs, vegetables, and fruits can effectively alleviate the hallmarks of lung cancer. As a molecular therapeutic agent, UA disrupts prolonged inflammation, augments antioxidant enzyme defense, attenuates tumor growth signal, tissue invasion/metastasis, limits unrestrained proliferation, fosters apoptosis, and regulates immune response in lung cancer. This review will most notably focus on the current source of UA availability, phytochemistry, bioavailability, safety, toxicity, and salient pharmacotherapeutic properties in addition to the preclinical and clinical information currently available to recommend UA as a potential therapeutic agent for lung cancer targeting and prevention.
Progress in Analytical Techniques for Remogliflozin Etabonate, Vildagliptin And Metformin Hydrochloride: A Recently, Approved FDC
Authors: Kotadiya Rajendra , Joshi Prachi
Published: October 2022

Background:

Fixed-dose combinations (FDCs) are renowned formulations that contain two or more drugs pooled in a single dosage form. Their recognition is justified due to several advantages, such as impending therapeutic efficacy, reducing the episodes of adverse drug effects, having pharmacokinetic advantages, reducing pill burden, reducing the dose of individual drugs, and decreasing drug resistance development.

Objective:

Recently, an FDC tablet of remogliflozin etabonate (100 mg), vildagliptin (50 mg), and metformin HCl (500/1000 mg) has been approved for the treatment of type 2 diabetes mellitus. No analytical method has been reported thus far for this newly approved combination.

Methods:

Thus, this review collected and simplified information on reported analytical techniques and physicochemical and biological properties for the above-cited FDCs. The authors have explored various authenticated scientific journals, and simplified information was presented to meet the objectives.

Results:

The reported methods are spectroscopy (40%, 20% & 33%), HPTLC (10%, 14% & 20%), HPLC (50%, 49% & 41%), hyphenated techniques (Nil, 14% & 5%) and electrophoresis methods (Nil, 2% & 1%) for remogliflozin etabonate, vildagliptin and metformin HCl, respectively.

Conclusion:

Such extensive data would be useful to analysts in developing an analytical method for the analysis of the recently approved FDCs
TMMGdb - Tumor Metastasis Mechanism-associated Gene Database
Authors: Ng Ka-Lok , Liu Hsueh-Chuan , Mekala Venugopala Reddy , Huang Chien-Hung
Published: October 2022

Background:

At present, all or the majority of published databases report metastasis
genes based on the concept of using cancer types or hallmarks of cancer/metastasis. Since tumor metastasis
is a dynamic process involving many cellular and molecular processes, those databases cannot
provide information on the sequential relations and cellular and molecular mechanisms among
different metastasis stages.

Objective:

We incorporate the concept of tumor metastasis mechanism to construct a tumor metastasis
mechanism-associated gene (TMMG) database based on using the metastasis mechanism concept.

Methods:

We utilized the text mining tool, BioBERT to mine the titles and abstracts of the papers
and identify TMMGs.

Results:

This tumor metastasis mechanism-associated gene database (TMMGdb) contains a wealth
of annotations.To check the reliability of TMMGdb, we compared the proportions of housekeeping
genes (HKGs) in TMMGdb, HCMDB, and CMgene, the results showed that around 20% of the
TMMGs are HKGs, and the proportions are highly consistent among the three databases. Compared
with the HCMDB and CMgene databases, TMMGdb is able to find a more recent (on or after 2017)
collection of publications and TMMGs. We provided six case studies to illustrate the uniqueness of
the TMMGdb database.

Conclusion:

TMMGdb is a comprehensive resource for the biomedical community to understand the dynamic
process, molecular features, and cellular processes involved in tumor metastasis. TMMGdb provides
four interfaces; ‘Browse’, ‘Search’, ‘DEG Search’ and ‘Download’, for users to investigate the causal
effects among different metastasis stages; the database is freely accessible at http://hmg.asia.edu.tw/
TMMGdb.
WITHDRAWN: Comparative Evaluation of Colistin Susceptibility Testing by Disk Diffusion and Broth Microdilution Methods: An Experience from a Tertiary Care Hospital
Authors: Kaur Navneet , Tak Vibhor , Nag Vijaya Lakshmi , Agarwal Ashwini , Bhatia Pradeep Kumar , Gupta Neeraj , Khera Daisy , Goel Akhil Dhanesh
Published: October 2022

Since the authors are not responding to the editor’s requests to fulfil the editorial requirement, therefore, the article has been withdrawn from the journal "Infectious Disorders - Drug Targets"

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultane-ously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Ethnotherapeutic Uses of Aquatic Animals in the North Eastern Region of
India: A Preliminary Observation
Authors: Dutta Uma , Daimari Enush
Published: October 2022

Since ancient times humans have been associating themselves with animals to derive various
benefits which include the therapeutic values of animals. Zootherapy is in practice among the
indigenous people of various parts of the world. The indigenous people living in the North Eastern
(NE) region of India also know the medicinal values of animals and they have been using many animals
in the treatment of various health ailments. This region is bestowed with many nature’s gifts,
among which the vast water bodies are considered the best. The diverse terrain of the region has
made varieties of aquatic animals exist. Hence, it has become favourable for the indigenous people
to use the easily available resources - aquatic animals for the treatment of health ailments. This precious
indigenous knowledge is restricted locally and is handed down from one generation to the
other through verbal communication. Consequently, this knowledge has started perishing. Making
proper documentation of the traditional uses of aquatic animals of this region in the treatment of
health ailments is intended in the present study. Attempts have also been made to reveal the presence
of bioactive components in the aquatic animals of the region. The present study will be helpful
while analyzing the therapeutic potentials of aquatic animals and then preparing drugs for clinical
purposes.
Fractionation of biodiesel by urea inclusion to improve its cold flow properties and provide feedstocks for chemicals/polymers production
Authors:   Purdue University, Junli Liu , Tao Bernie ,   Purdue University
Published: October 2022

Biodiesel is viewed as the alternative to petroleum diesel, but its poor cold flow properties constrained its utilization. Cloud point, the onset temperature of thermal crystallization, is one standard for evaluating cold flow properties. The saturated components significantly influence cloud point, and fractionation of biodiesel to remove saturated components effectively reduces the cloud point. Distillation and thermal crystallization are the fractionation based on the phase equilibrium and own the disadvantages of low yields and slow production rate. This work describes a unique method to fractionate FAME at room range temperatures by forming solid urea inclusion compounds (UIC). Urea inclusion fractionation provides a way to reduce the cloud point of mixtures of FAME by preferentially removing high melting-point linear saturated FAME components. Since soybean oil is the primary feedstock for biodiesel in the United States, the effects of the mass ratio of urea to FAMEs, the mass ratio of methanol to FAMEs, and the type of solvents on urea inclusion fractionation were carried out on FAMEs from soybean oil in urea inclusion fractionation. In addition, FAMEs from other sources were used to test the feasibility of urea inclusion fractionation on the cold flow properties. According to the experiments, the cloud point of biodiesel from soybean oil after urea fractionation could be as low as -52 °C. The separation efficiency and selectivity were measured according to the driving force in urea inclusion fractionation. Compared to distillation and thermal fractionation, urea inclusion fractionation could reach high yields and good cold flow properties.
Pengaruh Media Tanam Dan Pupuk Daun Terhadap Aklimatisasi Pertumbuhan Bibit Anggrek Dendrobium (Dendrobium sp.)
Authors: Putri Ardiah Virana , Rahayu Aldila Putri , Wardiyati Tatik
Published: October 2022

Anggrek (Dendrobium sp.) sebagai salah satu komoditas tanaman hias yang termasuk tanaman epifit dan cukup popular di Indonesia. Tanaman anggrek ini memiliki nilai ekonomis yang cukup tinggi dan diminati konsumen cukup banyak. Produksi tanaman anggrek menunjukkan peningkatan pada tahun 2017 sebesar 20.045.577 tangkai, sedangkan pada tahun 2018 sebesar 24.717.840 tangkai (BPS, 2019). Permintaan yang terus meningkat harus diikuti dengan persediaan bibit dalam jumlah yang besar dan mutu yang baik. Penelitian ini dilakukan untuk mengetahui dan mempelajari pengaruh media tumbuh dan jenis pupuk daun yang sesuai untuk pertumbuhan tanaman anggrek (Dendrobium sp.). Penelitian ini merupakan penelitian faktorial yang menggunakan Rancangan Petak Terbagi (RPT) dengan menggunakan 2 faktorr yaitu faktor pertama sebagai petak utama adalah perlakuan pupuk daun Mamigro (P1), Super Bionik (P2), Grow Quick LB (P3) dan pada faktor kedua sebagai anak petak adalah perlakuan media tanam arang kayu (M1), moss hitam (M2), serabut kelapa (M3), arang sekam (M4). Berdasarkan hasil analisis diketahui bahwa terdapat interaksi antara penggunaan pupuk daun dengan media tanam terhadap panjang tanaman sebesar 8,30 cm, panjang daun sebesar 5,27 cm, jumlah daun 5,00 helai dan lebar daun sebesar 0,48 cm. Penggunaan pupuk daun Grow Quick LB dengan media tanam arang sekam menunjukkan hasil yang terbaik pada pertumbuhan tanaman anggrek.
Evaluation of Breastfeeding App Features: Content Analysis Study
Authors: Dinour Lauren M , Pole Antoinette
Published: October 2022

Background

While a variety of health apps abound, less than half of adults in the United States report using a health app, despite the ubiquity of smartphones among users aged 18 to 49 years. Several studies have examined the use of breastfeeding apps; however, less is known about the types of features found on these apps and what factors might influence app ratings.

Objective

This paper seeks to characterize breastfeeding apps, assess whether apps with higher user ratings differ from apps with lower user ratings in their tracking and nontracking features, and analyze whether the type and number of features predict user star ratings and whether an app is higher- or lower-rated.

Methods

Using a cross-sectional design, a convenience sample of breastfeeding apps was culled from the Apple App Store (iOS) and Google Play Store (Android). Content analysis of the apps (N=82) was conducted using a schema of 87 items, which was then compiled into 9 topical indices for breastfeeding, bottle feeding, solid foods, infant health, infant care, technical characteristics, informatics, informational characteristics, and interactivity. Analysis consisted of descriptive statistics, the Mann-Whitney U test, and Spearman rank correlations. Linear regression and binary logistic regression analyses were conducted to determine which features predicted user star ratings.

Results

On average, users rated breastfeeding apps 4.4 of 5 stars. Two-thirds of apps (n=54) were higher rated (≥4.5 stars), and one-third (n=28) were lower rated (<4.5 stars). Higher-rated apps offered more tracking features for breastfeeding, bottle feeding, solid foods, infant health, and infant care than lower-rated apps. The breastfeeding, solid-food, and technical indices explained 17% of user star ratings. For each additional breastfeeding and solid-food feature, we can expect to see a 27% and 35% increase, respectively, in user star ratings. Additionally, as the number of solid-food features increased, the odds that the app is higher rated increased 1.58 times.

Conclusions

Our findings suggest user ratings are driven in part by tracking features, specifically those related to breastfeeding and solid foods. The proliferation of mobile health apps offers opportunities for parents and caregivers to track behaviors associated with infant feeding and other health metrics in a dynamic, detailed, and comprehensive manner. Hence, breastfeeding apps have the potential to promote and support breastfeeding among users.
Evaluating the Impact on Clinical Task Efficiency of a Natural Language Processing Algorithm for Searching Medical Documents: Prospective Crossover Study
Authors: Park Eunsoo H , Watson Hannah I , Mehendale Felicity V , O'Neil Alison Q ,   Clinical Evaluators
Published: October 2022

Background

Information retrieval (IR) from the free text within electronic health records (EHRs) is time consuming and complex. We hypothesize that natural language processing (NLP)–enhanced search functionality for EHRs can make clinical workflows more efficient and reduce cognitive load for clinicians.

Objective

This study aimed to evaluate the efficacy of 3 levels of search functionality (no search, string search, and NLP-enhanced search) in supporting IR for clinical users from the free text of EHR documents in a simulated clinical environment.

Methods

A clinical environment was simulated by uploading 3 sets of patient notes into an EHR research software application and presenting these alongside 3 corresponding IR tasks. Tasks contained a mixture of multiple-choice and free-text questions. A prospective crossover study design was used, for which 3 groups of evaluators were recruited, which comprised doctors (n=19) and medical students (n=16). Evaluators performed the 3 tasks using each of the search functionalities in an order in accordance with their randomly assigned group. The speed and accuracy of task completion were measured and analyzed, and user perceptions of NLP-enhanced search were reviewed in a feedback survey.

Results

NLP-enhanced search facilitated more accurate task completion than both string search (5.14%; P=.02) and no search (5.13%; P=.08). NLP-enhanced search and string search facilitated similar task speeds, both showing an increase in speed compared to the no search function, by 11.5% (P=.008) and 16.0% (P=.007) respectively. Overall, 93% of evaluators agreed that NLP-enhanced search would make clinical workflows more efficient than string search, with qualitative feedback reporting that NLP-enhanced search reduced cognitive load.

Conclusions

To the best of our knowledge, this study is the largest evaluation to date of different search functionalities for supporting target clinical users in realistic clinical workflows, with a 3-way prospective crossover study design. NLP-enhanced search improved both accuracy and speed of clinical EHR IR tasks compared to browsing clinical notes without search. NLP-enhanced search improved accuracy and reduced the number of searches required for clinical EHR IR tasks compared to direct search term matching.
Social Media Recruitment Strategies to Recruit Pregnant Women Into a Longitudinal Observational Cohort Study: Usability Study
Authors: Pekarsky Chloe , Skiffington Janice , Leijser Lara M , Slater Donna , Metcalfe Amy
Published: October 2022

Background

Use of social media for study recruitment is becoming increasingly common. Previous studies have typically focused on using Facebook; however, there are limited data to support the use of other social media platforms for participant recruitment, notably in the context of a pregnancy study.

Objective

Our study aimed to evaluate the effectiveness of Facebook, Twitter, and Instagram in recruiting a representative sample of pregnant women in a longitudinal pregnancy cohort study in Calgary, Alberta, between September 27, 2021, and April 24, 2022.

Methods

Paid advertisements were targeted at 18- to 50-year-old women in Calgary, with interests in pregnancy. Data regarding reach, link clicks, and costs were collected through Facebook Ads Manager (Meta Platforms, Inc) and Twitter Analytics (Twitter, Inc). The feasibility of each platform for recruitment was assessed based on the recruitment rate and cost-effectiveness. The demographic characteristics of the participants recruited through each source were compared using the chi-square test.

Results

Paid advertisements reached 159,778 social media users, resulting in 2390 link clicks and 324 participants being recruited. Facebook reached and recruited the highest number of participants (153/324, 47.2%), whereas Instagram saw the highest number of link clicks relative to the number of users who saw the advertisement (418/19,764, 2.11%). Facebook and Instagram advertisements were cost-effective, with an average cost-per-click of CAD $0.65 (US $0.84; SD $0.27, US $0.35) and cost-per-completer of CAD $7.89 (US $10.25; SD CAD $4.08, US $5.30). Twitter advertisements were less successful in terms of recruitment and costs. Demographic characteristics of participants did not differ based on recruitment source, except for education and income, where more highly educated and higher-income participants were recruited through Instagram or Twitter. Many issues related to fraudulent responses were encountered throughout the recruitment period.

Conclusions

Paid social media advertisements (especially Facebook and Instagram) are feasible and cost-effective methods for recruiting a large sample of pregnant women for survey-based research. However, future research should be aware of the potential for fraudulent responses when using social media for recruitment and consider strategies to mitigate this problem.
Effects of a Web-based Weight Management Education Program on Various Factors for Overweight and Obese Women: Randomized Controlled Trial (Preprint)
Authors: Han Yunmin , Sung Hoyong , Kim Geonhui , Ryu Yeun , Yoon Jiyeon , Kim Yeon Soo
Published: October 2022

BACKGROUND

Mediated diet and exercise methods yield effective short-term weight loss but are costly and hard to manage. However, web-based programs can serve many participants, offering ease of access and cost-efficiency.

OBJECTIVE

This study aimed to compare the effectiveness of a web-based weight management program through web-based education alone (MINE) or combined with tailored video feedback (MINE Plus) with a control (CO) group.

METHODS

This intervention included 60 Korean women with overweight and obesity (BMI≥23 kg/m2) aged 19 years to 39 years old. We randomly allocated 60 participants to each of 3 groups: (1) MINE group (web-based education video and self-monitoring app), (2) MINE Plus group (web-based education video, self-monitoring app, and 1:1 tailored video feedback), and (3) CO group (only self-monitoring app). Web-based education included nutrition, physical activity, psychological factors, medical knowledge for weight loss, goal setting, and cognitive and behavioral strategies. Tailored feedback aimed to motivate and provide solutions via weekly 10-minute real-time video sessions. The intervention lasted 6 weeks, followed by a 6-week observation period to assess the education's lasting effects, with evaluations at baseline, 6 weeks, and 12 weeks. A generalized linear mixed model was used to evaluate time and group interactions.

RESULTS

In the intention-to-treat analysis including all 60 participants, there were significant differences in weight change at 6 weeks in the MINE and MINE Plus groups, with mean weight changes of –0.74 (SD 1.96) kg (P=.03) and –1.87 (SD 1.8) kg (P<.001), respectively, while no significant change was observed in the CO group, who had a mean weight increase of 0.03 (SD 1.68) kg (P=.91). After 12 weeks, changes in body weight were –1.65 (SD 2.64) kg in the MINE group, –1.59 (SD 2.79) kg in the MINE Plus group, and 0.43 (SD 1.42) kg in the CO group. There was a significant difference between the MINE and MINE Plus groups (P<.001). Significant group × time effects were found for body weight in the MINE and CO groups (P<.001) and in the MINE Plus and CO groups (P<.001), comparing baseline and 12 weeks. Regarding physical activity and psychological factors, only body shape satisfaction and health self-efficacy were associated with improvements in the MINE and MINE Plus groups (P<.001).

CONCLUSIONS

This study found that the group receiving education and tailored feedback showed significant weight loss and improvements in several psychological factors, though there were differences in the sustainability of the effects.

CLINICALTRIAL

Korea Disease Control and Prevention Agency (KDCA) KCT0007780: https://cris.nih.go.kr/cris/search/detailSearch.do/22861
Home Health Care Clinicians’ Use of Judgment Language for Black and Hispanic Patients: Natural Language Processing Study (Preprint)
Authors: Topaz Maxim , Song Jiyoun , Davoudi Anahita , McDonald Margaret , Taylor Jacquelyn , Sittig Scott , Bowles Kathryn
Published: October 2022

BACKGROUND

A clinician’s biased behavior toward patients can affect the quality of care. Recent literature reviews report on widespread implicit biases among clinicians. Although emerging studies in hospital settings show racial biases in the language used in clinical documentation within electronic health records, no studies have yet investigated the extent of judgment language in home health care.

OBJECTIVE

We aimed to examine racial differences in judgment language use and the relationship between judgment language use and the amount of time clinicians spent on home visits as a reflection of care quality in home health care.

METHODS

This study is a retrospective observational cohort study. Study data were extracted from a large urban home health care organization in the Northeastern United States. Study data set included patients (N=45,384) who received home health care services between January 1 and December 31, 2019. The study applied a natural language processing algorithm to automatically detect the language of judgment in clinical notes.

RESULTS

The use of judgment language was observed in 38% (n=17,141) of the patients. The highest use of judgment language was found in Hispanic (7,167/66,282, 10.8% of all clinical notes), followed by Black (7,010/65,628, 10.7%), White (10,206/107,626, 9.5%), and Asian (1,756/22,548, 7.8%) patients. Black and Hispanic patients were 14% more likely to have notes with judgment language than White patients. The length of a home health care visit was reduced by 21 minutes when judgment language was used.

CONCLUSIONS

Racial differences were identified in judgment language use. When judgment language is used, clinicians spend less time at patients’ homes. Because the language clinicians use in documentation is associated with the time spent providing care, further research is needed to study the impact of using judgment language on quality of home health care. Policy, education, and clinical practice improvements are needed to address the biases behind judgment language.